bluuebunny/crossref_metadata_2025 huggingface dataset:
É POSSÍVEL APRENDER UMA LÍNGUA ESTRANGEIRA NA REALIDADE DA ESCOLA PÚBLICA? APRESENTANDO MÉTODOS ALTERNATIVOS PARA O ENSINO E APRENDIZAGEM DA LÍNGUA INGLESA ELABORADOS COM A PARTICIPAÇÃO DE ALUNOS CEARENSES DE ESCOLA PÚBLICA
Authors: Albuquerque Márcia Régia Ximenes
Published: April 2023

A língua inglesa já faz parte do cotidiano das crianças e jovens adolescentes brasileiros quando interagem com redes sociais, softwares, games, cinema, música, radio, podcast, TV e outros universos da comunicação com linguagem tecnológica. Ir às compras no supermercado, por exemplo, consiste numa ação de contato visual constante com a língua inglesa. Entretanto, quando se fala do ensino e aprendizagem do inglês na escola pública, professores e estudantes esbarram em muitas dificuldades materiais e didáticas. É possível aprender a língua inglesa numa realidade aonde a maioria das escolas públicas não possui laboratório de inglês e/ou ferramentas como TV, áudio e internet para todos? Para responder a essa pergunta foram desenvolvidas e vivenciadas e metodologias alternativas de ensino e aprendizagem da língua inglesa juntamente com alunos da escola pública estadual de ensino médio EEM Mariano Martins, localizada em Fortaleza, Ceará, Brasil. As referidas metodologias foram incubadas em 05 distintos projetos com o objetivo de fomentar as habilidades listening, speaking, reading e writing no contexto das realidades socioeconômicas, ambientais e culturais do aluno. Os pesquisadores Kumaravadivelu (2003); Alves e colaboradores (2009); Hook (2013); Bacich e Moran (2018); El Kadri (2020); Guilherme e colaboradores (2022) entre outros, foram importantes bases referenciais durante o desenvolvimento do presente trabalho. Para ter acesso às opiniões dos alunos sobre a experiência vivenciada em sala de aula com as referidas metodologias foi aplicado um questionário a uma amostra de 156 alunos (1º, 2º e 3º anos do ensino médio) da EEM Mariano Martins. Os dados foram coletados e tratados estatisticamente no programa Excel. Os resultados obtidos evidenciaram que a maioria da amostra de alunos entrevistados (83%) acha importante adquirir a língua inglesa, pois, são bem maiores as oportunidades de emprego e melhores salários com a aquisição dessa ferramenta. Nesse sentido, viajar para fora do país é meta para uma média de 87% da amostra de alunos entrevistados. Quanto ao sucesso das metodologias alternativas vivenciadas por eles na escola, 87% da amostra de alunos entrevistados afirmou que obteve melhorias em identificar (ver) e escrever em inglês, mas, ainda persiste a dificuldade de falar em inglês. As barreiras que existem para treinar a falar uma língua estrangeira na escola pública como a baixa quantidade de laboratórios, notebooks, aparelhos de som e internet para todos mitigam o sucesso do trabalho.
AVALIAÇÃO DE DEFEITOS TIPO "GOUGE" EM TUBOS DE AÇO INOX 304L UTILIZADOS NA FABRICAÇÃO DE AGULHAS HIPODÉRMICAS*
Authors: Iartelli Alexandre
Published: April 2023

A produção de cânulas, materiais utilizados na fabricação de dispositivos médicos, é feita a partir de uma tira de aço inoxidável 304L laminado em tubos e posteriormente soldado por processo GTAW. Após esse procedimento, o tubo sofre uma série de passes de trefilação com recozimento e sem recozimento, para diminuir seu diämetro. Por fim, são realizadas as etapas de corte, apontamento e limpeza do material. Durante a trefilação, uma série de defeitos chamados “GOUGE” é encontrada, provocando altas perdas nos processos, em função das desconformidades com as especificações técnicas. Inicialmente, no intuito de caracterizar e detectar possíveis causas dos defeitos foram analisadas as características do processo, desde a soldagem até a trefilação sem recozimento. Em seguida, foram feitas análises com microscopia de varredura, para avaliar algumas características metalúrgicas do material. Como o objetivo era caracterizar o defeito, diversas causas possíveis surgiram, como a influência da corrente ou velocidade de soldagem, temperatura de tratamento juntamente com as reações do gás Amônia na geração das desconformidades, a velocidade de trefilação ou a quantidade de óleo lubrificante. Concluiu-se que o processo de soldagem não foi o causador da falha, bem como a trefilação sem recozimento. A possibilidade da causa da descontinuidade ficou com o processo de trefilação com recozimento. Assim, diversas propostas para trabalhos futuros surgiram.
O FEDERALISTA: SEPARAÇÃO DE PODERES E DEFESA DE REPÚBLICA REPRESENTATIVA
Authors: Fagundes Pedro Ribeiro , Braga Júnior Sérgio Alexandre de Moraes
Published: April 2023

O Federalista discorre sobre a Constituição dos Estados Unidos da América de 1787, trazendo contribuições originais e essenciais ao entendimento da organização do Estado norte-americano. O presente artigo discute dois temas que se configuram centrais nos debates travados na obra em questão: sua teoria da separação dos poderes; e a defesa de uma república representativa como forma de combater os males advindos das facções. Para isso, realiza-se pesquisa qualitativa, que, por método dedutivo, aborda artigos da obra O Federalista, assim como recorre a bibliografia que busca compreendê-la e discuti-la – analisando-se, assim, as questões mais relevantes relacionadas a tais temas.
O DIREITO À EDUCAÇÃO DE ACORDO COM AS CONSTITUIÇÕES BRASILEIRAS
Authors: Silva Roberta Morais da
Published: April 2023

A educação enquanto direito foi fixada nos textos constitucionais brasileiros desde a Carta de 1824 até a Carta Cidadã de 1988. Houve artigos específicos destinados à educação, alguns ora ressaltavam, ora defendiam e ora reconheciam a educação enquanto direito, enquanto que em outros textos constitucionais, este direito por vezes apresentava-se subjetivo ou até mesmo negado em alguns aspectos. Nesse sentido, o objetivo deste trabalho é analisar a conjuntura histórica da educação enquanto direito com base nas constituições brasileiras. Em termos metodológicos, o estudo se desenvolveu por meio de uma pesquisa bibliográfica e documental, do tipo descritiva, seguindo uma abordagem de caráter qualitativo. Explicita-se que não houve limitações para o desenvolvimento desta revisão bibliográfica e documental, visto que a literatura acerca do assunto é extensa. Por fim, foi possível compreender que a inscrição do direito fundamental à educação no texto constitucional brasileiro é o resultado de um longo processo histórico marcado por avanços e retrocessos. É produto de uma longa história de conquistas sociais cujo desenrolar ocorreu em contextos marcados pelo alheamento da participação popular no processo democrático. Após análise dos textos constitucionais desde 1824 até a Carta de 1988, percebe-se que houve avanços significativos no âmbito educacional brasileiro. Ressalta-se que a Constituição Federal de 1988 veio trazer significativas contribuições e um fio de esperança num cenário desolador de desigualdade, e avançou sensivelmente em matéria de direitos sociais, como a educação, e não é sem razão: a educação é apontada por estudiosos e pesquisadores como uma forma eficaz de promover o desenvolvimento do indivíduo e da sociedade. São inegáveis as dificuldades, os problemas e os obstáculos que se apresentam atualmente ao êxito do sistema educacional no nosso país. Dentre estes, têm-se o ideário neoliberal, o qual impede, tarda e retrocede a efetivação do direito fundamental à educação previsto na Constituição Cidadão. Acredita-se que este estudo possa contribuir com o trabalho dos especialistas e gestores públicos que atuam na área, ao apresentar um quadro que permita compreender a evolução do direito à educação nas constituições brasileiras.
SINDICABILIDADE DO ATO ADMINISTRATIVO: A RELEITURA PROMOVIDA PELO SUPREMO TRIBUNAL FEDERAL NO JULGAMENTO DA ACO 3.451/DF
Authors: Azevedo Edgar Meira Pires de , Góes Ricardo Tinoco de
Published: April 2023

Tendo em vista que a pandemia de Covid-19, além da grave emergência de saúde causada, também gerou crises profundas nos campos econômicos, político-ideológico e de governabilidade; destinando ao Judiciário a solução de diversas questões que em situação de normalidade não seriam de sua alçada, pesquisa-se sobre a decisão proferida pelo Supremo Tribunal Federal no julgamento da ACO 3451/DF, na qual a Corte possibilitou a autorização automática para que o Estado do Maranhão importasse e distribuísse a vacina Sputnik V para a sua população, a fim de analisar se referida postura adotada, além de promover a releitura da sindicabilidade do ato administrativo está de acordo com os dispositivos constitucionais. Realiza-se então uma pesquisa de finalidade básica estratégica, objetivo descritivo e exploratório, sob o método dedutivo, com abordagem qualitativa e realizada pelos procedimentos bibliográficos e documentais. Diante disso, verifica-se que a decisão tomada pelo STF no julgamento da ACO 3451/DF afronta cabalmente o princípio da divisão funcional do poder, expresso no art. 2º da Constituição Federal, bem como culmina por violar o próprio direito à saúde, disposto no art. 196 da Carta Maior.
Resenha do livro “A BNCC na contramão do PNE 2014-2024: avaliação e perspectivas.”
Authors: Lima Tácyla Agum Theotonio de , Torres Juliana Rezende
Published: April 2023

O texto trata de uma resenha sorbe o livro " A BNCC na contramão do PNE 2014-2024". organizado por Márcia Angela da S.  Aguiar e Luiz Fernandes Dourado, a obra apresenta diversas contribuições para a discussão sobre as políticas curriculares no contexto da construção e anuência da BNCC. Este texto resulta do trabalho de dez autores que elaboraram um conjunto de relatos, reflexões e críticas sobre a BNCC e suas implicações em relação às demais políticas setoriais e ao Plano Nacional de Educação (PNE) – o que se deu no contexto da Conferência Nacional Popular de Educação 2018 (CONAPE 2018).
Phytochemical Screening, Total Phenolic, and Potential of Methanol Extract Musa balbisiana Colla as Antioxidant and Anti-Gout
Authors: Irawan Candra , Sukiman Maman , Enriyani Riri , Dwi Putri Imalia , Noviyanti Aulia , Dewanta Avisani , Ayudhitira Tiara
Published: April 2023

In this study, Musa balbisiana Colla seeds were extracted using Ultrasonic Assisted Extraction method. it was found that seeds extract of Musa balbisiana Colla contained alkaloid, phenolic, saponin, tannin and steroid glycoside compounds by phytochemical test. Antioxidant activity was determined by 1,1-diphenyl-2- picrylhydrazil and ferric reducing antioxidant power method while allopurinol was used to determine non uric acid capacity of Musa balbisiana Colla seeds extract. The total phenolic content of Musa balbisiana Colla seeds extract was 375mg/mg gallic acid. Antioxidant activity test was carried out using 1,1-diphenyl-2- picrylhydrazil method and ferric reducing antioxidant power method with the result in the form of Inhibitory Concentration 50. Inhibitory Concentration 50 value of Musa balbisiana Colla seeds extract was around (94.27±0.22) mg/L by 1,1-diphenyl-2- picrylhydrazil method which was classified as a very strong antioxidant activity. Inhibitory Concentration 50 value of Musa balbisiana Colla seeds extract using ferric reducing antioxidant power method was around (409.91±2.35)mg/L which was classified as very weak antioxidant activity. Anti-uric acid activity of Musa balbisiana Colla seeds was higher than the synthetic anti-uric acid drug allopurinol, which was around 38.27% and allopurinol was about 2.80%. These results illustrate that the seeds extract of Musa balbisiana Colla have the potential material as an ingredient in treating diseases caused by gout.
Development and Validation of a RP-HPLC Method for the determination of Venlafaxine hydrochloride in bulk and Pharmaceutical Dosage Forms
Authors: Sri K. Bhavya , Begum Maimuna , Narmada Narmada , Sumakanth Mogili
Published: April 2023

A simple, accurate, precise and rapid reverse phase high performance liquid chromatography method was developed and validated for the analysis of venlafaxine hydrochloride in bulk and marketed pharmaceutical dosage form. The chromatographic separation was carried out using a Phenomenex C18, (250mm × 4.6mm × 5µ) column. The optimum mobile phase consisted of ammonium acetate buffer, methanol (60:40) with pH adjusted to 5. The mobile phase was delivered isocratically at a flow rate of 1mL/min with UV detection at 227nm. Venlafaxine hydrochloride was eluted at 2 minutes. The method was validated for linearity, precision, accuracy, robustness and recovery. The method was linear in the concentration range of 15-165µg/ml with correlation coefficient 0.9997. limit of detection and limit and quantification were found to be 185ng/ml and 563ng/ml respectively.
COVID-19 Activity of Some 9-Anilinoacridines substituted with Pyrazole against SARS CoV2 Main Protease: An In-silico Approach
Authors: Rajagopal Kalirajan , Kannan R. , Aparna B. , Varakumar P. , Pandiselvi A. , Gowramma B.
Published: April 2023

COVID-19 is affected in more than 200 countries in the world. In this article, some pyrazole bearing 9-anilinoacridines(1a-z) were designed by in-silico studies for SARS-CoV-2 Mpro inhibitory activity. The docking for 1a-z against SARS-CoV-2 Mpro (5R82.pdb) targeting corona virus using Schrodinger suit. The Glide module is used for docking, qikprop for in-silico ADMET screening and Prime MM-GB/SA to determine binding energy of ligands. From the results, many compounds are significantly binding with SARS-CoV-2 Mpro with high G-score when compared to one of the currently recommended drug for COVID19, Hydroxychloroquine (-5.47). From results, many compounds exhibited similar interactions with SARS-CoV-2 Mpro and the aminoacids between GLN19 and GLY143 plays major role for binding. The in-silico ADMET properties are within the recommended values. The MM-GBSA calculations for most of the potent inhibitors are stable. In conclusion, 1t,m,j,o are SARS-CoV-2 Mpro inhibitors and may be useful for significant COVID19 activity after further refinement.
Representações do Feminino na Literatura, Artes e Mídias
Authors: Costa Cindy Conceição Oliveira , Lira Rhusily Reges da Silva , Meneses Allana Cristina Sales
Published: April 2023

Os ensaios aqui reunidos são de pesquisadoras e pesquisadores de diversas instituições de ensino superior do Brasil, os quais utilizam como aporte teórico, principalmente, os estudos de gênero, a crítica feminista e transfeminista. Assim, possuindo 17 capítulos, a presente publicação traz pesquisas que variam em análises para além do âmbito literário e que buscam contribuir com esse campo de estudo que está em constante atualização, haja vista que segue o desenvolvimento social e a luta do movimento feminista. Tais pesquisas possibilitam o ato de refletir, de forma plural e não essencialista, as figuras femininas e sua relação com as artes. Ademais, apresentam visões de mundo femininas, nas quais o papel e a imagem que se tem das mulheres podem ser reavaliados de forma crítica, uma vez que apresentam ideias que tornam possível ver e compreender essa autorrepresentação como um caminho para a liberdade intelectual e autonomia feminina.
Social anxiety in medical students
Authors: Jacomo Felipe Cardoso , Souza Gabriel Fernandes de , Viana Isabella Santos , Oliveira Mateus Domingues , Kyriakidis Nikole Vieira , Ferreira Vanessa Mourão , Oliveira Marcos
Published: April 2023

Introduction: When marked by persistent fear and intensified by social anxiety, anxiety becomes indicative of Social Anxiety Disorder (SAD). Thus, the active methodology proved to be a complicated condition for social phobia due to the need to work as a team, since, in social anxiety patients, the reasons for fear are mainly speech, writing and criticism of their respect. Objective: To evaluate the occurrence of SAD and associated factors in the medical course with a problem-based learning methodology. Methods: This is a cross-sectional, quantitative study that evaluated the occurrence of SAD at a University Center in a sample of 333 medical students studying from the 1st to the 6th period in the city of Montes Claros - MG, using the Anxiety Scale Liebowitz Social Test in the self-administered version and the Sociodemographic Questionnaire. Results: The study identified that most participants are female (62.8%), most have worsened anxiety throughout the course (66.37%) and psychologists interfere with school performance (85.6%). Conclusion: This study strengthened the relationship between TAS and active methodology in the medical course.
HLA-I allelic variants related to resistance and susceptibility to severe SARS-CoV-2 infection
Authors: Menezes Lis , Garcia Liliane Rodrigues , Casseb Samir Mansour Moraes
Published: April 2023

Objective: Identify allelic variants of HLA I related to possible resistance or susceptibility to severe SARS-CoV-2 infection and describe this relationship. Methods: This study is a descriptive literature review based on articles published between the years 2020 and 2021 in the databases: SciELO, ScienceDirect, PubMed /MEDLINE, Capes Periodicals, BVS, Wiley Online Library; that was available in Brazilian Portuguese and English. Results: The analyzed studies demonstrated that HLA I alleles can be considered like determinants of resistance or susceptibility to COVID-19 due to their ability to bind to SARS-CoV-2 peptides, influencing in the regulation of the immune response against the SARS-CoV-2 virus. Conclusions: There is an agreement between the authors regarding the role of HLA I like a determinant of resistance and genetic susceptibility to SARS-CoV-2, where the HLA-B*46:01 was the most cited (20% frequency) as allele that confers susceptibility to the virus, and HLA-A *02: 01 and HLA-A *31: 01 were the most cited among the alleles that may confer protection against the most severe infection of COVID-19 (frequency of 19% and 18 % respectively).
Impacto da pandemia de COVID-19 nos procedimentos dermatológicos no Brasil
Authors: Silveira Bührnheim Maria Eduarda , Pasqualotto Eric , Fonseca da Silva Amanda Carolina , Carvalho de Oliveira Beatriz , Merlin Maschietto Vítor Maurício , Leite da Silva Neto Luiz Fernando , Mendes de Araújo Junior Geraldo , Avelar Pires Carla Andrea
Published: April 2023

Introdução: Atendimentos dermatológicos foram prejudicados pela pandemia da COVID-19, com diagnósticos atrasados e tratamentos interrompidos. Pacientes com câncer de pele, por exemplo, foram especialmente afetados, já que a progressão de lesões e o risco de metástase aumentam. Nesse contexto, o objetivo do estudo foi analisar o impacto da pandemia da COVID-19 na realização de procedimentos cirúrgicos em dermatologia no Brasil. Metodologia: O estudo é retrospectivo, descritivo e quantitativo. Os dados foram obtidos a partir de registros do Sistema de Informações de Saúde (TABNET) do DATASUS. Foram analisadas “Pequenas cirurgias e cirurgias de pele, tecido subcutâneo e mucosa” entre os Procedimentos Hospitalares do SUS do período de janeiro de 2016 a dezembro de 2020, sendo consideradas as variáveis Região e Caráter de Atendimento. Resultados: Foram realizadas 554.591 pequenas cirurgias e cirurgias de pele, tecido subcutâneo e mucosa entre 2016 e 2020 no Brasil. O Sudeste apresentou o maior número de registros (47,15%; n=261.477). No período de 2016 a 2019 houve um aumento de 16,44% nos procedimentos realizados, totalizando 130.099 em 2019. Entretanto, no ano de 2020 houve queda de 38,59% em relação a 2019, com 79.887 procedimentos. Ademais, em todos os anos predominou o caráter eletivo, totalizando 402.344 (72,5%). O aumento foi de 25,2% no período de 2016 a 2019, mas em comparação a 2019, houve uma redução de 44,9% em 2020. Discussão: A pandemia da COVID-19 reduziu o número de profissionais especializados atuantes nos ambulatórios, com o remanejamento da mão de obra e reestruturação do serviço para o atendimento aos infectados pela COVID-19, refletindo na redução de consultas e procedimentos, resultando no atraso do acompanhamento e resolução de doenças dermatológicas. Conclusão: Conclui-se, portanto, que o a realização de procedimentos dermatológicos foi fortemente influenciada pela pandemia da COVID-19, com efeito direto no funcionamento de serviços da especialidade.
Is miR-21 A Therapeutic Target in Cardiovascular Disease?
Authors: Holland Antoinette , Enrick Molly , Diaz Arianna , Yin Liya
Published: April 2023

Review
Is miR-21 A Therapeutic Target in Cardiovascular Disease?

Antoinette Holland, Molly Enrick, Arianna Diaz, and Liya Yin *

Department of Integrative Medical Sciences, Northeast Ohio Medical University, Ohio 44272, USA.
* Correspondence: lyin@neomed.edu; Tel.: 330-325-6521; Fax: 330-325-5912
 
 
Received: 16 November 2022
Accepted: 29 November 2022
Published: 11 January 2023
 

Abstract: microRNA-21 (miR-21) serves a multitude of functions at the molecular level through its regulation of messenger RNA. Previous research has sparked interest in the role of miR-21 as a potential therapeutic target in cardiovascular diseases. miR-21 expression contributes to the differentiation, proliferation, and maturation of many cell types, such as fibroblasts, endothelial cells, cardiomyocytes, and endothelial progenitor cells. The function of miR-21 depends upon its expression level in the specific cell types and downstream targets, which determine cell fate. Under pathological conditions, the expression level of miR-21 is altered, leading to abnormal gene regulation of downstream signaling and cardiovascular diseases such as hypertension, cardiac hypertrophy and fibrosis, atherosclerosis, and heart failure. Agomirs or antagomirs can be introduced into the respective tissue type to reverse or stop the progression of the disease. Exosomes in the extracellular vesicles, which mediate many cellular events with high biocompatibility, have a high potential of efficiently delivering miR-21 to their targeted cells. The critical role of miR-21 in cardiovascular disease (CVD) is indisputable, but there are controversial reports on the function of miR-21 in the same disease. This discrepancy sparks interest in better understanding the role of miR-21 in different tissues under different stages of various diseases and the mechanism of how miR-21 inhibitors work.
A Minimally Invasive Approach for Cardiac Electrophysiology Studies in Mice
Authors: Zi Min , Abraham Sabu , D'souza Alicia , Hutchings David , Prehar Sukhpal , Wang Xin , Cartwright Elizabeth J
Published: April 2023

Article
A Minimally Invasive Approach for Cardiac Electrophysiology Studies in Mice

Min Zi , * , Sabu Abraham , Alicia D'souza , David Hutchings , Sukhpal Prehar , Xin Wang , and Elizabeth J Cartwright

Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, United Kingdom
* Correspondence: min.zi@manchester.ac.uk
 
 
Received: 6 January 2023
Accepted: 9 February 2023
Published: 25 March 2023
 

Abstract: Atrial fibrillation and ventricular tachycardia are commonly seen in clinic. Different approaches have been developed to investigate underlying mechanisms. Transvenous approach (TA) is widely used for studies but has several drawbacks. We therefore developed a novel minimally invasive approach (MIA) for mechanistic studies. Study included 27 male C57BL/6J mice, 19 for MIA and 8 for TA. Under general anaesthesia, ECG was recorded. A key hole was made on the right first intercostal space by separating the intercostal muscles, followed by the exposure of the superior vena cava and the top of the atrium. An EPR-800 catheter was inserted vertically, perpendicular to the chest, for atrial pacing and flatly over the ventricles for ventricular pacing. Burst S1–S1 and decremental S1–S2 pacing protocols were performed to evaluate SA recovery time (SNRT), the atrioventricular node effective refractory period (AVN-ERP), Wenckebach period, ventricular ERP, and arrhythmia susceptibility. MIA was successfully performed in all 19 mice without any complications. One mouse died during TA due to venous rupture. Compared MIA with TA, surgical time were significantly shorter (P<0.0001). Wenckebach period was shorter as well (P<0.05). No difference was found in baseline sinus cycle length, SNRT, correct SNRT, AVN-ERP, ventricular ERP, and arrhythmia susceptibility (all P>0.05). The novel MIA outplays TA by providing similar outcomes of PES but consuming less time, demanding less surgical expertise, and reducing the potential of surgical complications. Given the minimal tissue injury, it also provides great potential as a recovery procedure for longitudinal study.
Recent Clinical Successes in Liposomal Nanomedicines
Authors: Gu Wenjie , Andrews Gavin P. , Tian Yiwei
Published: April 2023

Review
Recent Clinical Successes in Liposomal Nanomedicines

Wenjie Gu , Gavin P. Andrews , and Yiwei Tian , *

School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
* Correspondence: y.tian@qub.ac.uk
 
 
Received: 19 December 2022
Accepted: 26 January 2023
Published: 3 February 2023
 

Abstract: The intrinsic limitations of cancer therapies promoted the development of safer liposomal nanocarriers capable of better distributing the payload away from normal tissues. Since then, liposomal nanocarriers have been considered the primary drug delivery system for many active pharmaceutical ingredients. These systems are now frequently investigated for the treatment of many infectious diseases. Along with the tremendous progress in the anticancer and antifungal liposomal nanomedicines, we have also gradually realised the difficulties associated with the existing liposomal nanocarrier designs. A better understanding of the nanocarrier-bio interactions may provide a new paradigm in liposomal nanocarrier design and better clinical endpoint efficacy. This short review focuses on the progress and benefits of two market-approved liposomal nanomedicines for cancer and fungal treatments.
The Need for Pest Control and the Possibilities of Pesticide Development in Accordance with the Requirements of Safe Food Production
Authors: Oros Gyula
Published: April 2023

The scientific and technical development that made the industrial revolution possible not only transformed the social structure worldwide, but also imposed new requirements on food production and necessitated changes in plant cultivation procedures. Within this, pest control management underwent a radical change in the last century, and the use of pesticides (synthetic chemicals) became widespread. The main reason for this is the maintenance of the profitability of the production by guaranteeing the reliability of the harvest. This latter aspect usually is not taken into the account by those who oppose the use of pesticides. In the past half century, the pesticide assortment has undergone significant changes, currently around 2000 different active ingredients are available, among which the proportion of synthetic super selective molecules has increased. Although this contributed to the reduction of concerns about their use, the widespread application of these mono site inhibitors imposed new requirements. On the one hand due to the acquired resistance against them within the pest population, and on the other hand due to the appearance of new, previously insignificant pest species. Among them, the phytopathogenic bacteria are of increasing importance: we currently do not have a sufficiently effective preparation that can be used to control them widely in plant cultivation. There is an urgent need to develop pesticides suitable for combating newly emerging diseases. In this paper, the author examined this question from the inventor’s point of view, sharing the experiences of six decades of research in this area.
Identity, Loss, and Singing Transcendence after the End of the World
Authors: Novak Jelena
Published: April 2023

Review-essay of the film opera Upload and the chamber music theater piece The Book of Water by Michel van der Aa.
University Changes in the 4.0 Educational Era: A Study into Moroccan Students' Interests
Authors: Amini Najia , Sefri Youssef , Chakli Abdelhak , Mahiri Fadwa , Aassoul Abderrahim , Radid Mohamed
Published: April 2023

Faced with the challenges presented by the transition to Industry 4.0, deep and rapid transformation is required for higher education to meet the demands of the fourth industrial revolution. This article aims to investigate students' perceptions of various components of their academic ecosystem. our study is interested in examining the preferred teaching models, competencies, and fields of study that higher education should develop and national/international mobility. A questionnaire survey was conducted using a quantitative approach to collect students' perceptions; 97 students from Hassan 2 University participated in the study. The findings indicate that students are interested in blended learning, that they require programs to build their managerial and employability skills, that mobility is a fundamental element of education 4.0, and that its impact on employability development is recognized. The study enhances our understanding of higher education students' interactions within their university ecosystem. This study might be beneficial for policymakers and educational decision-makers in the transformation toward a university 4.0.
Implementasi Model Pembelajaran Teaching Factory (TeFa) untuk Menanamkan Jiwa Kewirausahaan Siswa Kelas XII Tata Busana SMK Negeri 1 Sumbawa Besar
Authors: Mastur Mastur
Published: April 2023

Implementasi model pembelajaran teaching factory bertujuan untuk menanamkan jiwa kewirausahaan dengan memberikan pengalaman kerja dan ketrampilan pada siswa. Model pembelajaran teaching factory berbasis unit produksi di SMK bermanfaat juga sebagai tempat menimba pengalaman, melatih dan menanamkan jiwa kewirausahaan para siswa. Penerapan model pembelajaran teaching factory pada siswa kelas XII kompetensi keahlian Tata Busana SMK Negeri 1 Sumbawa Besar dipandang efektif dalam penanaman jiwa kewirausahaan siswa pada tiga indikator yang meliputi motivasi untuk maju, kreativitas & inovatif, serta komitmen. Dalam penelitian ini ketiga indikator ini memiliki tingkat persentase yang cukup tinggi sehingga dapat merepresentasikan tingkat jiwa kewirausahaan yang ada pada diri siswa. Siswa yang memiliki tiga indikator ini akan selalu berusaha menyelesaikan pekerjaan dengan sebaik-baiknya dengan mengerahkan segenap kemampuan dan ketrampilan untuk mencapai cita-cita yang diinginkan, penghasilan, harga diri dan masa depan yang gemilang. Hal ini tentunya menggambarkan adanya peningkatan jiwa kewirausahaan para siswa dengan diterapkannya model pembelajaran Teaching Factory di sekolah, sehingga implementasi model pembelajaran teaching factory dianggap efektif dalam menanamkan jiwa kewirausahaan pada siswa kelas XII kompetensi keahlian Tata Busana SMK Negeri 1 Sumbawa Besar.
Strategi Pembelajaran Kooperatif Learning pada Pembelajaran PAI Kurikulum 2013 di SMP 35 Medan
Authors: Neliwati Neliwati , Lesmana Baron , Sari Leni Erlina , Azhari Restu Audy
Published: April 2023

Penelitian ini akan membahas tentang strategi pembelajaran kooperatif learning Dalam rangka mengetahui bagaimana pembelajaran kooperatif dimasukkan ke dalam kurikulum 2013 di SMP Negri 35 Medan, penelitian ini akan menganalisis metodologi pembelajaran kooperatif dalam strategi pembelajaran PAI. Menurut metodologi penelitian kualitatif ini cenderung menggunakan analisis tetapi juga menggabungkan data yang sudah ada berdasarkan pengembangan, dapat disimpulkan bahwa siswa memerlukan pembelajaran kooperatif tidak hanya untuk melibatkan mereka dalam diskusi tentang pelajaran saat ini tetapi juga untuk memecahkan masalah belajar bersama, memungkinkan mereka untuk berpikir lebih bebas, meningkatkan motivasi mereka untuk belajar dan memberi mereka kesempatan untuk bereksperimen sehingga mereka lebih giat belajar, maka dari itu harus adanya persaingan di kelas sehingga semua anggota kelompok dapat menguasai materi uh7pelajaran dengan baik Hal ini membuktikan bahwa Dari proses kelompok dapat diketahui anggota kelompok mana yang sangat membantu dan tidak membantu, Karena dapat dilihat dari urutan dan tahapan kegiatan kelompok. Model pembelajaran kooperatif dikembangkan untuk mencapai hasil belajar dalam bentuk presentasi akademik, toleransi menerima keragaman, dan pengembangan keterampilan sosial.
Implementasi Model SIUUL untuk Mengembangkan Kecakapan Berpidato
Authors: Andraeni Magfiroh , Sutisna Yogga Hadi , Desi Anisa Rahma , Watini Sri
Published: April 2023

Memiliki strategi image yang baik adalah suatu hal yang harus dilakukan. Brand berarti gambaran positif yang melekat di masyarakat sehingga perusahaan atau lembaga selalu di ingat dalam jangka yang panjang. Sama halnya dengan perguruan tinggi di tuntut memiliki image yang positif memiliki keunggulan di banding dengan lainnya, untuk keberhasilan mutu kualitas serta lulusan yang dapat di terima bekerja di dunia pendidikan. Penelitian ini bertujuan untuk mengetahui daya saing lulusan prodi Pendidikan Guru Madrasah Ibtidaiyah mudah mendapatkan pekerjaan yang sesuai dengan bidangnya menjadi guru kelas baik di SD/MI/SDI. Jenis penelitian ini adalah penelitian kualitatif. Data diperoleh melalui teknik wawancara, observasi, studi kepustakaan dan teknik analisis data model interaktif. Hasil ini menunjukkan bahwa strategi brand image program studi Pendidikan Guru Madrasah Ibtidaiyah dalam meningkatkan daya saing lulusan di pengaruhi beberapa faktor yaitu: membangun brand awareness, peran pemimpin, tawaran beasiswa, sosial media marketing, kurikulum, kegiatan unggulan, kerjasama dengan berbagai mitra dan stakeholder. Dari faktor tersebut berdampak dengan dikenalnya prodi Pendidikan Guru Madrasah Ibtidaiyah dengan meningkatnya jumlah mahasiswa.
Mitigasi Bencana Gempa Bumi di Cianjur
Authors: Muksin Zainal , Rahim Abdur , Hermansyah Andi , Samudra Azhari Aziz , Satispi Evi
Published: April 2023

Mitigasi dapat dilakukan berupa pembangunan fisik atau peningkatan kemampuan dalam mengahadapi bencana serta kesiap-siagaan pemerintah dalam pengorganisasian terhadap tindakan yang tepat dan akurat sehigga masyarakat memiliki persiapan dalam menghadapi bencana. Oleh karena itu apabila perencanaan tersebut telah dilaksanakan pemerintah namun terdapat keterbatasan alat tekologi kebencanaan serta bencana alam yang sulit diprediksi maka perlu adanya pola pengembangan science yang berorintasi pada mitigasi bencana. Selanjutnya apabila saat bencana telah terjadi pemerintah harus bersigap dalam memberikan tindakan cpat tanggap dalam proses penyelamatan serta mengevakuasi para korban dan memberikan kebutuhan darurat para korban. Dengan demikian pasca bencana terjadi masih terus diberikan penanganan berupa alokasi bantuan dana yang tidak hanya dari pemerintah daerah namun dengan berbagai pihak yang ikut serta dalam memberikan bantuan utnuk membangun kembali kabupaen cianjur yang terdampak bncana alam yakni gempa bumi.
Implementasi Permainan Puzzle terhadap Kemampuan Membaca Huruf Hija’iyah pada Murid Cerebra Palsy Tipe Spastik Kelas V D di SLB Negeri 2 Jeneponto
Authors: B Hasni , Mustafa Mustafa , Sulasminah Dwiyatmi , Shaleh Wizerti Ariastuti
Published: April 2023

Penelitian membahas mengenai rendahnya kemampuan melafalkan huruf hija'iyyah siswa cerebral palsy kelas V pada mapel pendidikan agama Islam. Tujuan dari penelitian ini adalah untuk mengetahui: (1) Kemampuan membaca huruf hija'iyyah pada kondisi awal 1 (A1); (2) Kemampuan membaca huruf Hijayah pada fase intervensi (B); (3) Kemampuan membaca huruf hijaiyah setelah diberi perlakuan (A2); (4) Pengaruh penerapan bermain puzzle hijaiyah terhadap kemampuan membaca huruf hijaiyah siswa cerebral palsy kelas V di SLB Negeri 2 Jeneponto. Teknik perolehan data yang digunakan adalah tes. Subyek penelitian adalah siswa kelas V cerebral palsy berinisial MF. kuantitatif merupakan pendekatan yang dipergunakan dalam penelitian ini, jenis penelitian ini menggnakankan Single Subject Research (SSR), desain A-B-A. Hasil penelitian menunjukkan bahwa (1) Kemampuan membaca huruf Hija'iyah sangat kurang pada siswa kelas V spastic cerebral palsy Baseline 1 (A1). (2) Kemampuan membaca huruf Hija'iyah siswa penderita spastic cerebral palsy tipe V selama permainan puzzle meningkat menjadi baik. (3) Kemampuan membaca huruf hija'iyah meningkat setelah diberi puzzle pada siswa penderita cerebral palsy spastik tipe V dibandingkan sebelum diberi perlakuan. (4) Kemampuan membaca huruf hija iyah siswa cedera otak kejang, berdasarkan hasil analisis penyakit silang yaitu pada keadaan basic 1 (A1), kemampuan siswa cerebral palsy meningkat menjadi kategori baik. Artinya bermain puzzle hijaiyah dapat meningkatkan kemampuan membaca huruf hijaiyah pada siswa cerebral palsy.
Peran Gaya Kepemimpinan Kepada Tingkat Kinerja Petugas Rutan Kelas IIB Pelaihari
Authors: Saleh Muhammad , Subroto Mitro
Published: April 2023

Kepemimpinan ialah aktivitas pemimpin dalam mempengaruhi orang lain, membimbing, serta memotivasi untuk mencapai tujuan bersama. Kepemimpinan yang baik dapat memberikan pengaruh positif terhadap tingkat kinerja para petugas. Dan sebaliknya kepemimpinan yang kurang baik dapat memberikan dampak negatif terhadap kinerja para petugas di dalamnya. Disetiap UPT Pemasyarakatan memiliki kondisi serta situasi yang berbeda-beda. Sehingga pemimpin harus dapat menerapkan gaya kepemimpinan yang fleksibel tergantung pada kondisi dan situasi yang ada. Agar dapat mewujudkan kepemimpinan yang baik yang dapat terus berkembang, berinovasi serta mencapai tujuan bersama. Dalam penelitian ini menggunakan metode pendekatan kualitatif deskriptif yang mana dilakukan dengan mencari suatu jawaban dari peran gaya kepemimpinan yang sesuai di Rutan Kelas IIB Pelaihari, yang nantinya dapat digambarakan sesuai dengan fakta-fakta yang ada dilapangan serta dengan tabahan studi literatur dari berbagai sumber yang ada. Dengan dilakukannya wawancara kepada pihak-pihak yang penting dalam struktur organisasi Rutan Kelas IIB Pelaihari.Dengan metode serta analisis yang diterapakan didapatakan hasil bahwa gaya kepemimpinan menunjukkan hasil yang signifikan positif pada kinerja petugas di Rutan Kelas IIB Pelaihari. Dimana dalam menentukan gaya kepemimpinannya yang sesuai, seorang pemimpin melakukan pendekatan dengan bawahannya dengan menerima saran serta masukannya. Dengan begitu terjalin hubungan yang baik antara pemimpin dan bawahannya. Sehingga petugas dapat bekerja maximal.
An Analysis of Xueda Education's Financial Performance in the Context of Covid-19
Authors: Chen Ziyun
Published: April 2023

The Covid-19 pandemic has had a significant impact on large enterprises in China, resulting in closures and staff layoffs, which have negatively affected the training education industry. This paper presents a case study of Xueda Education, a listed company, to analyze its financial situation from 2017-2020, the first three years of the pandemic, and 2020-2023, another three years of the pandemic. The study uses financial indicators to discuss the development problems of training education in terms of profitability, development capacity, solvency, and operating capacity. A side-by-side comparison method is used to compare Xueda Education's financial performance with two other companies in the same field. The study concludes that Xueda Education's profitability, development capacity, solvency, and operating capacity decreased, especially in terms of operating capacity. The short-term solvency of the debt servicing capacity decreased, while the long-term solvency capacity did not change significantly. The study proposes solutions for improving the financial risk system and finding new ways to sustain the company. This paper provides valuable insights for policymakers and researchers in the training education industry to address the impact of Covid-19 on enterprises and the industry.
The Core Content and Practical Approach of China’s Global Security Initiative
Authors: Jing Lina , Ma Yugang , Zhong Yu
Published: April 2023

This research paper provides an overview of China’s Global Security Initiative, its essential components, and its practical implementation. Firstly, the paper highlights the significance of the Global Security Initiative in the broader context of China’s global security policy. It then outlines the core elements of the Global Security Initiative, which include promoting security cooperation, establishing a global security framework, and enhancing comprehensive security measures. Secondly, the author explores the practical approach of the Global Security Initiative, which emphasizes cooperation between states, international organizations, civil society, and the private sector. The author also describes the implementation of the Global Security Initiative, such as the establishment of the Global Security Initiative Working Group and its role in regional security cooperation. Furthermore, the author discusses how the Global Security Initiative fits into the Belt and Road Initiative. Lastly, the paper addresses the challenges posed by the Global Security Initiative, including the need for greater transparency and the establishment of an effective governance system. By offering insights into the Global Security Initiative and its implications for global security, the author provides valuable information on this topic. Overall, this paper provides a comprehensive overview of the Global Security Initiative, its core components, practical approach, implementation, and challenges, making it an informative read for anyone interested in China’s global security policy.
SECURE ONLINE VOTING BASED ON BLOCKCHAIN TECHNOLOGY
Authors:   Dept. Of CSE, SCSVMV (Deemed to be University), Saraswathi Dr. M , Rajesh Arikatla , Koteeswar Bommmisetti Hima Sagar
Published: April 2023

This paper is based on electronic voting machines, which are often used in elections and offer the ability to execute the process safely using blockchain technology. The prime aim of this system is to ensure security, integrity as well as transparency. One of the main considerations in the electronic voting site that offers a blockchain-based voting system to address a number of shortcomings of the current voting methods is voter privacy. The portal also offers a simple, dependable, rapid, and economical e-voting solution. Key Words: Blockchain technology, EVM’s, authentication, validation, security, decentralized voting.
CONTRIBUTION OF ANCIENT INDIAN MATHEMATICIANS
Authors:   Govt. Dr. Babasaheb Bhimrao Ambedkar PG College Dongargaon, Rajnandgaon C.G, Sahu Dr. Chetan Kumar
Published: April 2023

The history of any ancient civilization is often surrounded by mystery and controversy. Still, Western scholars have not given sufficient credit to the work of some ancient Indian mathematicians, notably Brahmagupta, Bodhayana and Bhaskara II, despite the fact that their entire works were translated into English by the nineteenth-century British Sanskrit scholar Henry Thomas Colebrooke. In the initial part was done by The purpose of this article is to lay out the facts and leave the reader free to interpret and evaluate them according to his own understanding of the subject. Sincere efforts have been made to bring the contribution of some ancient Indian mathematicians to the public. Keywords:- Right angled triangle, Decimal system, Alphanumeric system, Shulva Sutra.
Vehicle Pattern Recognition Using Machine Learning and Deep Learning
Authors:   Department of Information Technology & Dhanekula Institute of Engineering and Technology, Susanna Ch Lavanya , Kumar Chowdary Poka V N Anil , Sree Valli Tatiparthi Kamala , Priya Parasa Hari , Kumar Veeragandam Sai
Published: April 2023

Recently, there has been increased interest in intelligent transportation systems. The most important duty in this area is to classify and locate vehicles. Differentiating between the attributes of various cars is the task's main obstacle. The fact that a wide range of cars do not adhere to lane discipline makes vehicle classification and detection a challenging problem to pinpoint. In this tutorial, we've built a convolution neural network from the ground up to categorize and recognize objects using a contemporary convolution neural network based on fast regions. For classification and detection in this study, we took into account three different types of vehicles: buses, cars, and bikes. We'll employ a method that creates a bounding box using the complete image as input. Key Words: CNN, KNN, Linear Regression, SVM
Design For Testability Method To Sequential Circuit
Authors: RASHEED MOHAMMED , Rashid Taha , Bin Hamzah Muhammad , Jaber Ahmed , Sarhan Mohammed , Aldaraji Mustafa , Saidani Tarek , Rashid Ahmed
Published: April 2023

As the complexity of logic devices increased, it required more time and effort to manually design and verify tests, it was difficult to estimate test coverage, and the tests ran too slowly. This method is known as functional testing. Therefore, the industry adopted a design for test (DFT) strategy in which the design was updated to make testing simpler. In this work, a full scan testability method is going to be implemented to a sequential circuit (CUT). The CUT consists of at 6 D flip-flops and 10 logic gates. This CUT was designed using quartus prime software. The following steps are going to be implemented in this work: First, simulate the fault free circuit. Second, three faults were injected and tested to check if they can be detected or not. Finally, analyze the obtained results in terms of (what is the test pattern needed, how the fault can be observed at output).
Advancing Construction with IoT and RFID Technology in Civil Engineering: A Technology Review
Authors: M. Mijwil Maad , Kamal Kant Hiran  , Ruchi Doshi  , Omega John Unogwu
Published: April 2023

Nowadays, the realm of civil engineering has expanded to encompass Internet of Things (IoT) technologies, which can contribute to making sustainable, high-performing, and durable buildings. These innovative techniques allow for monitoring concrete structures and developing inspection and maintenance plans to ensure their long-term integrity. By leveraging the power of IoT technologies in civil engineering, we can improve the efficiency and effectiveness of building maintenance, reduce costs, and optimize the use of resources, all while promoting sustainability and longevity in the built environment. In this article, a technical review will be made of RFID technology's significance in civil engineering. RFID technology is utilized in inspecting building materials, especially in reinforced concrete, monitoring cavities in riverbeds, monitoring stress in reinforced concrete structures, monitoring corrosion of reinforced concrete reinforcements, monitoring excavations at a construction site and many others. This article concluded that RFID technology has significant benefits in the field of civil engineering, and using the Internet of Things, it greatly impacts following up on building structures and conducting inspections and immediate maintenance of them.
Caesarean Section Delivery in India: A Comparative Assessment of Geographical Variability Using Nationally Representative Survey Factsheet Data
Authors: Tripathy Brajaraj , Jena Ayusman , Pandey Anuj Kumar , Mishra Sidharth Sekhar , Mishra Chhandasri
Published: April 2023

Background: In line with global trends, India has witnessed a sharp rise in C-section (CS) deliveries, especially in the private sector.
Methodology: Study attempts to explore change in CS delivery in India at national, regional and State/UT levels. We have used factsheet data from the most recent nationally representative survey data i.e., NFHS to examine changes in private and public healthcare facilities, and to determine a difference in rural and urban in CS deliveries.
Results: The CS rate has increased from 17.2% to 21.5% in 2019-21. CS was more than twice (40.9%) amongst the private healthcare facilities during the fourth round of NFHS which has shown a considerable increase during the fifth round of NFHS (47.4%). There is equal distribution (12.8% during 2015-16 to 17.6% in 2019-21 in rural areas v/s 28.2% during 2015-16 to 32.3% in 2019-21in urban areas) of CS deliveries amongst the rural and urban areas to the total deliveries.
Conclusion: Study found that with every one in five deliveries being caesarean, the figure is significantly high as per the recommended cut off by WHO. Thus, it is essential to explore factors regarding emergency or elective caesarean section and to understand if the health facilities are following the recommended protocols for performing CS deliveries.