bluuebunny/crossref_metadata_2025 huggingface dataset:
A Cost of Misclassification Adjustment Approach for Estimating Optimal Cut-Off Point for Classification
Authors: Ampomah O.-A. , Minkah R. , Kallah-Dagadu G. , Nortey E. N. N.
Published: May 2024

Classification is one of the main areas of machine learning, where the target variable is usually categorical with at least two levels. This study focuses on deducing an optimal cut-off point for continuous outcomes (e.g., predicted probabilities) resulting from binary classifiers. To achieve this aim, the study modified univariate discriminant functions by incorporating the error cost of misclassification penalties involved. By doing so, we can systematically shift the cut-off point within its measurement range till the optimal point is obtained. Extensive simulation studies were conducted to investigate the performance of the proposed method in comparison with existing classification methods under the binary logistic and Bayesian quantile regression frameworks. The simulation results indicate that logistic regression models incorporating the proposed method outperform the existing ordinary logistic regression and Bayesian regression models. We illustrate the proposed method with a practical dataset from the finance industry that assesses default status in home equity.
Optimal Gasoline Price Predictions: Leveraging the ANFIS Regression Model
Authors: Eliwa Entesar Hamed I. , El Koshiry Amr Mohamed , Abd El-Hafeez Tarek , Omar Ahmed
Published: May 2024

This study presents an in-depth analysis of gasoline price forecasting using the adaptive network-based fuzzy inference system (ANFIS), with an emphasis on its implications for policy-making and strategic decisions in the energy sector. The model leverages a comprehensive dataset from the U.S. Energy Information Administration, spanning over 30 years of historical price data from 1993 to 2023, along with relevant temporal features. By combining the strengths of fuzzy logic and neural networks, the ANFIS approach can effectively capture the complex, nonlinear relationships present in the data, enabling reliable price predictions. The dataset’s preprocessing involved decomposing the date into year, month, and day components to enhance the model’s input features. Our methodology entailed a systematic approach to ANFIS regression, including data preparation, model training with the inclusion of the previous week’s prices as an additional feature, and rigorous performance evaluation using MSE, RMSE, and correlation coefficients. The results indicate that incorporating previous prices significantly enhances the model’s accuracy, as reflected by improved scores and correlation metrics. The findings have significant implications for the energy sector, where stakeholders can leverage the ANFIS model’s insights for strategic decision-making. Accurate gasoline price forecasts are instrumental in devising pricing strategies, managing risks associated with price volatility, and guiding policy formulation. The model’s predictive capability enables energy companies to optimize resource allocation, plan for future investments, and maintain competitive advantage in a market influenced by fluctuating prices. Moreover, policymakers can utilize these predictions to assess the impact of energy policies on market prices and consumer behavior, ensuring that regulatory measures align with market dynamics and sustainability goals. In addition to the ANFIS model, we also employed Vector Autoregression (VAR) and Autoregressive Integrated Moving Average (ARIMA) models to validate our approach and provide a comprehensive understanding of time series forecasting within the energy sector. Notably, the ANFIS model achieves a score of 0.9970 and a robust correlation of 0.9985, demonstrating its ability to accurately forecast gasoline prices based on historical data and features. The integration of these traditional techniques with advanced ANFIS modeling offers a robust framework for accurate and reliable gasoline price prediction, which is vital for informed policy-making and strategic planning in the energy industry.
Exploring the Therapeutic Potential of β-Hydroxybutyrate (BHB) in Clear Cell Renal Cell Carcinoma: A Journey into Fat Browning, Autophagy, and Tumor Slimming
Authors: Rezaei Roya , Abdali Larki Asra , Hosseinzadegan Rosa , Dashti Zahra , Tarkashvand Saba , Akhoondi Reihaneh , Siri Morvarid , Shams Mesbah , Monsef Alireza , Dastghaib Sanaz
Published: May 2024

This study delves into the therapeutic potential of β-hydroxybutyrate (BHB) in clear cell renal cell carcinoma (ccRCC), a cancer known for its complex pathogenesis and resistance to conventional treatments. The research specifically explores the impact of BHB on cell viability, autophagy induction, and lipid metabolism in Caki-1 cells. The findings reveal that BHB significantly reduces ccRCC cell viability, particularly under low-glucose conditions. The combination of glucose and BHB treatment activates autophagy pathways, as evidenced by increased expression of autophagy-related genes (Beclin-1, LC3IIβ, and ATG5) and decreased expression of P62 after 48 and 72 hours. Moreover, the combined therapy enhances lipid metabolism, as indicated by elevated expression of PGC-1α and UCP-1, along with upregulation of ACSL3 and CPT1A, which are associated with lipid droplet formation and facilitate lipid breakdown within cells. The study concludes that BHB holds promise as a therapeutic agent for ccRCC, targeting abnormal lipid metabolism, inducing autophagy-mediated cell death, and promoting fat browning. The results suggest potential avenues for precision-guided nutritional therapies in ccRCC treatment, highlighting the innovative role of BHB in addressing the challenges posed by this cancer.
Overcoming Nutrient Stress: Integrin αvβ3-Driven Metabolic Adaptation Supports Tumor Initiation
Authors: Rainero Elena
Published: May 2024

Nutrient stress accompanies several stages of tumor progression, including metastasis formation. Metabolic reprogramming is a hallmark of cancer, and it has been associated with stress tolerance and anchorage-independent cell survival. Adaptive responses are required to support cancer cell survival under these conditions. In this issue of Cancer Research, Nam and colleagues showed that the extracellular matrix (ECM) receptor integrin β3 was upregulated in lung cancer cells in response to nutrient starvation, resulting in increased cell survival that was independent from ECM binding. Delving into the molecular mechanisms responsible for this, the authors found that integrin β3 promoted glutamine metabolism and oxidative phosphorylation (OXPHOS) by activating a Src/AMPK/PGC1α signaling pathway. Importantly, in vivo experiments confirmed that OXPHOS inhibition suppressed tumor initiation in an orthotopic model of lung cancer, while β3 knockout completely abrogated tumor initiation. These observations indicate that targeting signaling pathways downstream of αvβ3 could represent a promising therapeutic avenue to prevent lung cancer progression and metastasis.

See related article by Nam et al., p. 1630
Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Authors: Bukavina Laura , Ginwala Rashida , Eltoukhi Mohamed , Sindhani Mohit , Prunty Megan , Geynisman Daniel M. , Ghatalia Pooja , Valentine Henkel , Calaway Adam , Correa Andres F. , Brown Jason R. , Mishra Kirtishri , Plimack Elizabeth R. , Kutikov Alexander , Ghannoum Mahmoud , Elshaer Mohammed , Retuerto Mauricio , Ponsky Lee , Uzzo Robert G. , Abbosh Philip H.
Published: May 2024

Neoadjuvant chemotherapy (NAC) is linked with clinical advantages in urothelial carcinoma for patients with muscle-invasive bladder cancer (MIBC). Despite comprehensive research into the influence of tumor mutation expression profiles and clinicopathologic factors on chemotherapy response, the role of the gut microbiome (GM) in bladder cancer chemotherapy response remains poorly understood. This study examines the variance in the GM of patients with bladder cancer compared with healthy adults, and investigates GM compositional differences between patients who respond to chemotherapy versus those who exhibit residual disease.

Our study reveals distinct clustering, effectively separating the bladder cancer and healthy cohorts. However, no significant differences were observed between chemotherapy responders and nonresponders within community subgroups. Machine learning models based on responder status outperformed clinical variables in predicting complete response (AUC 0.88 vs. AUC 0.50), although no single microbial species emerged as a fully reliable biomarker.

The evaluation of short chain fatty acid (SCFA) concentration in blood and stool revealed no correlation with responder status. Still, SCFA analysis showed a higher abundance of Akkermansia (rs = 0.51, P = 0.017) and Clostridia (rs = 0.52, P = 0.018), which correlated with increased levels of detectable fecal isobutyric acid. Higher levels of fecal Lactobacillus (rs = 0.49, P = 0.02) and Enterobacteriaceae (rs = 0.52, P < 0.03) correlated with increased fecal propionic acid.

In conclusion, our study constitutes the first large-scale, multicenter assessment of GM composition, suggesting the potential for a complex microbial signature to predict patients more likely to respond to NAC based on multiple taxa.

Significance:

Our study highlights results that link the composition of the GM to the efficacy of NAC in MIBC. We discovered that patients with higher levels of Bacteroides experienced a worse response to NAC. This microbial signature shows promise as a superior predictor of treatment response over traditional clinical variables. Although preliminary, our findings advocate for larger, more detailed studies to validate these associations.
Microdeletion 3q13.2q21.2 in a Patient Previously Diagnosed with MOMO Syndrome
Authors: de Oliveira-Sobrinho Ruy Pires ,   Rare Genomes Project Consortium, Vieira Társis Paiva , Steiner Carlos Eduardo
Published: May 2024

Background: MOMO syndrome is a rare disorder with variable presentation and unknown etiology belonging to the overgrowth syndromes group. Case Presentation: The authors describe a patient presenting with severe developmental delay, absent speech, autism spectrum disorder, central nervous system malformations, bilateral optic atrophy, and postnatal overgrowth, besides a dysmorphic and progressive coarse face. A clinical diagnosis of MOMO syndrome was proposed, but he developed megaesophagus, megacolon, paraparesis, and severe acne during the clinical follow-up, which are not described in this condition. Whole-genome sequencing detected a deletion of 11.9 Mb at 3q13.2q21.2 comprising 80 genes, including the ZBTB20 gene associated with Primrose syndrome. Conclusion: Despite the atypical manifestations in this patient, the overlapping features between MOMO syndrome, Primrose syndrome, and 3q13.31 deletion led the authors to propose that MOMO syndrome could be part of the Primrose/3q13.31 microdeletion syndrome spectrum.
Needle Fetal Thoracoscopy: A Technique to Assist with Ultrasound-Guided Placement of Challenging Thoracoamniotic Shunts
Authors: Papastefan Steven T. , Liesman Daniel R. , Ott Katherine C. , Scorletti Federico , Pombar Xavier F. , Shaaban Aimen F. , Alhajjat Amir M.
Published: May 2024

Introduction: Fetal thoracoamniotic shunts are common lifesaving interventions but frequently require replacement. Needle fetal thoracoscopy is a technique that uses standard thoracoamniotic shunt introducer sheaths to permit direct visualization and even instrument manipulation during shunt deployment to facilitate optimal positioning and primary shunt function in the most challenging cases. Case Presentation: In this study, 5 patients who underwent needle fetal thoracoscopy-assisted thoracoamniotic shunt placement were reviewed. Three patients with large, macrocystic congenital pulmonary airway malformations (CPAMs) with evidence of worsening mediastinal shift and/or hydrops and 2 patients with large chylothorax with fetal hydrops were treated. Four cases had previous shunts that failed due to poor sonographic visualization during initial placement, cyst septations, shunt obstruction, or dislodgment. Needle fetal thoracoscopy was used to disrupt cyst walls and septations, clear hematoma, and confirm the optimal initial position of the shunt. In this series, 1 severe CPAM patient with a short cervix developed preterm labor postoperatively resulting in neonatal demise. The remaining 4 patients experienced resolution of hydrops and progressed to successful delivery with excellent neonatal outcomes. Conclusion: Needle fetal thoracoscopy is a procedure that may be selectively deployed in challenging thoracoamniotic shunt cases impacted by recurrent failure, poor sonographic windows, and challenging fetal positioning.
Plantas medicinais: cravos-de-defunto
Authors:   Universidade de São Paulo. Escola Superior de Agricultura Luiz de Queiroz, Santos Lais D’Isep dos , Capellari Júnior Lindolpho ,   Universidade de São Paulo. Escola Superior de Agricultura Luiz de Queiroz
Published: May 2024

O gênero Tagetes tem grande destaque como um grupo de plantas que pode ser cultivado com fins tanto medicinal como agronômico. Esse gênero compreende espécies herbáceas ou arbustivas anuais, genericamente chamadas de “cravos-de-defunto”, nativas do continente americano, especialmente do México, porém hoje distribuídas por todo o globo. As três principais representantes do gênero são as espécies Tagetes minuta L., encontrada como planta invasora de terrenos abandonados, Tagetes erecta L., muito utilizada no paisagismo, e Tagetes lunulata Ortega, que pode ser também cultivada em projetos paisagísticos ou considerada invasora.
Identification of the Molecular Components of Enhancer-Mediated Gene Expression Variation in Multiple Tissues Regulating Blood Pressure
Authors: Yaacov Or , Mathiyalagan Prabhu , Berk-Rauch Hanna E. , Ganesh Santhi K. , Zhu Luke , Hoffmann Thomas J. , Iribarren Carlos , Risch Neil , Lee Dongwon , Chakravarti Aravinda
Published: May 2024

BACKGROUND:

Inter-individual variation in blood pressure (BP) arises in part from sequence variants within enhancers modulating the expression of causal genes. We propose that these genes, active in tissues relevant to BP physiology, can be identified from tissue-level epigenomic data and genotypes of BP-phenotyped individuals.

METHODS:

We used chromatin accessibility data from the heart, adrenal, kidney, and artery to identify cis-regulatory elements (CREs) in these tissues and estimate the impact of common human single-nucleotide variants within these CREs on gene expression, using machine learning methods. To identify causal genes, we performed a gene-wise association test. We conducted analyses in 2 separate large-scale cohorts: 77 822 individuals from the Genetic Epidemiology Research on Adult Health and Aging and 315 270 individuals from the UK Biobank.

RESULTS:

We identified 309, 259, 331, and 367 genes (false discovery rate <0.05) for diastolic BP and 191, 184, 204, and 204 genes for systolic BP in the artery, kidney, heart, and adrenal, respectively, in Genetic Epidemiology Research on Adult Health and Aging; 50% to 70% of these genes were replicated in the UK Biobank, significantly higher than the 12% to 15% expected by chance (
P
<0.0001). These results enabled tissue expression prediction of these 988 to 2875 putative BP genes in individuals of both cohorts to construct an expression polygenic score. This score explained ≈27% of the reported single-nucleotide variant heritability, substantially higher than expected from prior studies.

CONCLUSIONS:

Our work demonstrates the power of tissue-restricted comprehensive CRE analysis, followed by CRE-based expression prediction, for understanding BP regulation in relevant tissues and provides dual-modality supporting evidence, CRE and expression, for the causality genes.
Asymmetries during Eyewall Replacement Cycles of Hurricane Ivan (2004)
Authors: Rojas Bruno S. , Didlake Anthony C. , Zhang Jun A.
Published: May 2024

The physical processes that govern eyewall replacement cycles (ERCs) in tropical cyclones (TCs) are not yet fully understood. In particular, asymmetric structures within the TC inner core have an uncertain role in ERC dynamics. This study analyzes the kinematic and precipitation asymmetric structures during successive ERCs in Hurricane Ivan (2004) using airborne Doppler radar observations. The azimuthal locations of these asymmetries are analyzed relative to the deep-layer (850–200 hPa) environmental wind shear vector. Two ERCs were analyzed at different stages of their evolution. During the concentric eyewall stage of the first ERC, the outer eyewall updrafts were strongest in the left-of-shear half, which also coincided with mesoscale descending inflow (MDI) just radially outward. Enhanced low-level convergence, updrafts, and MDI were collocated in a zone spiraling inward toward the strongest outer eyewall updrafts, suggesting that the vertical velocity asymmetry in the outer eyewall was possibly forced by a stratiform-induced cold pool similar to MDI impacts seen in past TC studies. During the final stage of the second ERC, the outer eyewall (now the singular primary eyewall) experienced an upwind shift in the precipitation and vertical velocity asymmetries. The updraft maximum shifted from the downshear-left quadrant to the downshear-right quadrant, and the precipitation maximum (downwind of the updraft maximum) shifted from left-of-shear to the downshear direction. This shift corroborates previous studies, which hypothesize that at the end of an ERC, the forcing mechanism that drives the eyewall vertical velocity asymmetry transitions from MDI/cold-pool processes to direct interaction with the environmental wind shear.
Studies of Protein Binding to Biomimetic Membranes Using a Group of Uniform Materials Based on Organic Salts Derived From 8-Anilino-1-naphthalenesulfonic Acid
Authors: Azevedo Ana M.O. , Nunes Cláudia , Moniz Tânia , Pérez Rocío L. , Ayala Caitlan E. , Rangel Maria , Reis Salette , Santos João L.M. , Warner Isiah M. , Saraiva M. Lúcia M.F.S.
Published: May 2024

Tuning the 8-anilino-1-naphthalenesulfonic acid (ANS) structure usually requires harsh conditions and long reaction times, which can result in low yields. Herein, ANS was modified to form an ANS group of uniform materials based on organic salts (GUMBOS), prepared with simple metathesis reactions and distinct cations, namely tetrabutylammonium (N4444), tetrahexylammonium (N6666), and tetrabutylphosphonium (P4444). These ANS-based GUMBOS were investigated as fluorescent probes for membrane binding studies with four proteins having distinct physicochemical properties. Liposomes of 1,2-dimyristoyl- sn-glycero-3-phosphocholine were employed as membrane models as a result of their ability to mimic the structure and chemical composition of cell membranes. Changes in fluorescence intensity were used to monitor protein binding to liposomes, and adsorption data were fitted to a Freundlich-like isotherm. It was determined that [N4444][ANS] and [P4444][ANS] GUMBOS have enhanced optical properties and lipophilicity as compared to parent ANS. As a result, these two GUMBOS were selected for subsequent protein-membrane binding studies. Both [N4444][ANS] and [P4444][ANS] GUMBOS and parent ANS independently reached membrane saturation within the same concentration range. Furthermore, distinct fluorescence responses were observed upon the addition of proteins to each probe, which demonstrates the impact of properties such as lipophilicity on the binding process. The relative maintenance of binding cooperativity and maximum fluorescence intensity suggests that proteins compete with ANS-based probes for the same membrane binding sites. Finally, this GUMBOS-based approach is simple, rapid, and involves relatively small amounts of reagents, making it attractive for high-throughput purposes. These results presented herein can also provide relevant information for designing GUMBOS with ameliorated properties.
Gendered labor: Appearance management and the unequal extraction of effort and time among ambassadors
Authors: Towns Ann E.
Published: May 2024

This article examines the gendered appearance management ambassadors do to properly represent states. Drawing on feminist sociologist theorizations of labor, and attentive to intersections with sexuality, class, and Western standards, the study shows the unequal extraction of time and effort from men and women as they manage their appearance in diplomacy. Theoretically, I argue that the gendered management of dress, hair, and adornments are better conceived of as labor than as habitus or capital. Empirically, the study focuses on appearance management among ambassadors posted to Washington D.C. 2018–2020. Relying on a wealth of data—an original time survey, ambassador interviews, and observations—the study makes three empirical claims about the diplomatic embodiment of states: (a) diplomatic appearance standards are largely gender binary, with male uniformity and female variation; (b) more time and effort is demanded from female than male ambassadors; and (c) diplomatic appearance standards demand gender labor that is inextricably linked with the management of sexuality, upper class conventions, and Western physical appearance norms for representing states. In short, individuals presenting as men or women (although apparently not nonbinary) may now represent states as ambassadors, but more labor is extracted from women in doing so.
Will a changing climate affect hatching success in cavity-nesting birds: A case study with Eastern Bluebirds (Sialia sialis)?
Authors: Rush Scott A , Weitzel Spencer L , Trent John A , Soehren Eric C
Published: May 2024

A significant body of evidence indicates that climate change is influencing many aspects of avian ecology. Yet, how climate change is affecting, and is expected to influence some aspects of the breeding ecology of cavity-nesting birds remains uncertain. To explore the potential linkage between timing of first clutch, and the influence of ambient temperature on hatching success, we used Eastern Bluebird ( Sialia sialis) nest records over a nine-year period from Alabama, USA. We investigated changes to annual clutch initiation dates, as well as variability in hatching success associated with ambient air temperatures during the incubation period. Using a simple linear model, we observed earlier annual egg laying dates over the nine years of this study with a difference of 24 days between earliest egg-laying date of the season. Daily temperature minima increased 2 °C across the nine-year time frame of this study. These data also indicate that Eastern Bluebird hatching success was the highest when mean ambient air temperature during incubation was between 19 °C and 24 °C (78%, as opposed to 69% and 68% above and below this temperature range, respectively). Our findings of increasing maxima, earlier maxima each year, and the lower minima of temperatures within our study area could expand the breadth of temperatures experienced by nesting Eastern Bluebirds possibly exposing them to temperatures outside of what promotes nesting success. These findings with a cavity-nesting bird highlight an optimal range of ambient temperatures associated with highest hatching success, conditions likely to be affected by climate change.
Phase change materials in textiles: synthesis, properties, types and applications – a critical review
Authors: Pritom Mohamad Mohiminul , Islam Md. Asraful , Moshwan Md. Mubashwir , Hossain Alimran , Hasan Md. Zayedul , Siddiquee Md. Abu Bakar , Ayatullah Hosne Asif A.K.M
Published: May 2024

Phase change properties of clothing gain attention of the researcher now for their significant unique ability to absorb, release, store, and deposit temperature during phase transition. Phase change materials have been widely used and utilized now in various fields, as well as in textiles. In apparel products, phase change materials are used to introduce various special features, especially its make garments smart or have technical functions. Various researchers pay attention to this area for its large organic and inorganic resources. This review paper summarizes the road map of phase change materials in textiles, including the way of synthesis, the characteristics of phase change materials, and their applications in smart textiles. In addition, the diverse usage of phase change materials in different textiles is discussed. It also tries to cover the principles of phase change behavior, phase change material types, and their thermal properties. After that, the paper will try to mention the potential benefits and challenges associated with utilizing phase change materials in various applications that have been discussed here. Finally, this paper concludes with the mass acceptance of phase change materials in various technological advancements, along with a short note about future research opportunities.
The Mediating Effect of Well-Being, Happiness, and Trust in the Relationship Between Work-Life Balance and Work Effectiveness in Seafarers
Authors: Senbursa Nihan , Dunder Emre
Published: May 2024

In the contemporary global context, seafarers persist as the uncelebrated heroes of international trade, despite their substantial contributions. The current estimate places the number of STCW- certified officers at 857 540, reflecting a notable increase of 10.8% since 2015. Nevertheless, there is a growing recognition of the imperative to accord specific attention to seafarers’ mental and physical well-being. During their tenures aboard ships, seafarers confront various challenges, including psychological well-being, work-life imbalance, dissatisfaction, diminished performance, and a sense of mistrust toward the organizational framework. The primary objective of this research is to scrutinize the nexus between work-life balance and work effectiveness, exploring the mediating roles of psychological well-being, organizational happiness, and organizational trust. A questionnaire-based survey is meticulously crafted to achieve this, employing a dataset comprising 420 seafarers engaged in diverse vessel types in Turkey, operating under both Turkish and international flags. Methodologically, structural equation modeling and correlation analyses are executed to assess the formulated research hypotheses rigorously. The empirical findings of this research reveal noteworthy mediating roles: psychological well-being exhibits a complete mediation effect, organizational happiness demonstrates a full mediation effect, and organizational trust manifests a partial mediation effect. These outcomes underscore the nuanced interplay between work-life balance and work effectiveness in the seafaring context. The implications of these findings extend significantly to the maritime sector and industry, accentuating the imperative for targeted interventions to enhance the well-being and performance of seafaring professionals.
Clinical Observations on the Combined Use of Hyperbaric Oxygenation and Conventional Medications in the Management of Type 2 Diabetes Mellitus Concurrent With Sudden Deafness
Authors: Chen Hua-Qin , Peng Yao , Feng Yu , Jin Tian-li
Published: May 2024

Objective: The aim of this study is to investigate the effectiveness of combining hyperbaric oxygen therapy (HBOT) with conventional pharmacological interventions in the management of type 2 diabetes mellitus concurrent with sudden deafness. Methods: A cohort of 96 patients diagnosed with sudden deafness was enrolled and subsequently randomized into 2 groups: a treatment group (n = 50) and a control group (n = 46). The control group received standard conventional treatment aimed at enhancing microcirculation and nutritional support for nerves, while the treatment group underwent conventional symptomatic treatment coupled with HBOT. The evaluation encompassed the monitoring of blood glucose and blood lipid levels, clinical efficacy, and absolute hearing threshold improvement in both groups. Results: Following the intervention, noteworthy reductions in blood glucose and blood lipid levels were observed in both groups compared to their respective pretreatment values. Furthermore, posttreatment values in the treatment group exhibited a statistically significant decrease in comparison to those in the control group ( P < .05). On assessing clinical efficacy posttreatment, the treatment group demonstrated a significantly higher efficacy than the control group ( P < .05). In addition, the absolute hearing thresholds in both groups exhibited a significant decrease posttreatment compared to baseline values. Notably, the treatment group displayed a statistically significant reduction in absolute hearing thresholds compared to the control group posttreatment ( P < .05). Conclusion: The combined therapeutic approach utilizing hyperbaric oxygen exhibits effectiveness in mitigating auditory impairment among individuals manifesting sudden deafness concomitant with type 2 diabetes mellitus. Furthermore, this treatment approach is associated with a concurrent reduction in blood glucose and blood lipid levels.
Patient perspectives on the unwanted effects of multidisciplinary pain management programmes: A qualitative study
Authors: Booth Gregory , Di Rosa Amanda , Corcoran Paula , Hallisey Charlotte , Lucas Andrew , Zarnegar Roxaneh
Published: May 2024

Objective

This study aimed to understand the impact of pain management programmes, focusing on the unwanted effects and their influence on patients’ long-term use of self-management strategies.

Design

Qualitative study.

Setting

Specialist musculoskeletal hospital in North London, England.

Participants

Patients with chronic musculoskeletal pain that have completed a pain management programme.

Intervention

Multidisciplinary pain management programmes.

Main measures

Data were collected regarding patients’ experiences and unwanted effects from the pain management programme using semi-structured interviews. Data were analysed using thematic analysis.

Results

Fourteen participant interviews were included in the analysis (median age 54 years, 12 females). Four themes were generated from the data: Benefits and burdens, Pain management programme and real life, Social support and Healthcare interventions. Unwanted effects included heightened anxiety related to negative interactions with peers, being in a new environment, worries about ability to cope with the programme, social anxiety from being in a group, the strain on families due to participants being away from home and a sense of abandonment at end of the programme. Burdens associated with implementing pain management strategies were identified, including the emotional burden of imposing their self-management on close family and competing demands with time and energy spent on self-management at the expense of work or home commitments.

Conclusions

Pain management programmes have an important role in helping patients to learn how to self-manage chronic pain. Their unwanted effects and the treatment burdens associated with long-term self-management may be an important consideration in improving the longevity of their beneficial effects.
Refined movement analysis in the staircase test reveals differential motor deficits in mouse models of stroke
Authors: Skrobot Matej , Sa Rafael De , Walter Josefine , Vogt Arend , Paulat Raik , Lips Janet , Mosch Larissa , Mueller Susanne , Dominiak Sina , Sachdev Robert , Boehm-Sturm Philipp , Dirnagl Ulrich , Endres Matthias , Harms Christoph , Wenger Nikolaus
Published: May 2024

Accurate assessment of post-stroke deficits is crucial in translational research. Recent advances in machine learning offer precise quantification of rodent motor behavior post-stroke, yet detecting lesion-specific upper extremity deficits remains unclear. Employing proximal middle cerebral artery occlusion (MCAO) and cortical photothrombosis (PT) in mice, we assessed post-stroke impairments via the Staircase test. Lesion locations were identified using 7 T-MRI. Machine learning was applied to reconstruct forepaw kinematic trajectories and feature analysis was achieved with MouseReach, a new data-processing toolbox. Lesion reconstructions pinpointed ischemic centers in the striatum (MCAO) and sensorimotor cortex (PT). Pellet retrieval alterations were observed, but were unrelated to overall stroke volume. Instead, forepaw slips and relative reaching success correlated with increasing cortical lesion size in both models. Striatal lesion size after MCAO was associated with prolonged reach durations that occurred with delayed symptom onset. Further analysis on the impact of selective serotonin reuptake inhibitors in the PT model revealed no clear treatment effects but replicated strong effect sizes of slips for post-stroke deficit detection. In summary, refined movement analysis unveiled specific deficits in two widely-used mouse stroke models, emphasizing the value of deep behavioral profiling in preclinical stroke research to enhance model validity for clinical translation.
Development of Macrotexture Test Method for Dense-Graded Asphalt Mixtures
Authors: Mergenmeier Andy , Mensching David J. , Sakhaeifar Maryam S. , Myers Leslie Ann , Veeraragavan Ram Kumar
Published: May 2024

The design and construction of pavements necessitate careful consideration of longevity, cost-effectiveness, sustainability, and safety, with a focus on enhancing the durability and lifespan of dense-graded asphalt (DGA) surface mixtures. This paper discusses a research project the Federal Highway Administration (FHWA) initiated to assess the macrotexture characteristics of DGA mixture pavement—particularly concerning safety at higher speeds. The project aims to develop an efficient testing procedure for measuring macrotexture during mixture design and field-testing processes, striking a balance between longevity, cost-effectiveness, sustainability, and safety in pavement design and construction. The study began with a comprehensive review of existing practices, leading to the selection and testing of a unique laser texture scanner capable of noncontact macrotexture measurement. The subsequent phase involved validating the suggested macrotexture measurement system through data collected from State-sponsored projects under the FHWA Mobile Asphalt Technology Center program. Macrotexture measurements were collected from field cores and laboratory-compacted specimens from various State departments of transportation projects and analyzed. Preliminary analysis of the limited dataset to date revealed a positive correlation between average macrotexture measurements from gyratory specimens’ top surface and field core macrotexture measurements. The FHWA developed a draft test method for measuring macrotexture on laboratory specimens and field cores, thereby aiming to reduce procedural variability. Interlaboratory macrotexture test results demonstrated good reproducibility, with an average coefficient of variation of approximately 20%. Overall, this research project seeks to advance the understanding and measurement of macrotexture in DGA mixture pavements and thereby contribute to the development of safe pavements.
Headache and Other Factors Modifying Cerebrospinal Fluid Opening Pressure in Pediatric Patients
Authors: Espitia Segura Oscar M. , Bedoya Morales Ana M. , Ramírez-Sierra Cristina L. , Farfán-Albarracín Juan D. , Pérez Cárdenas Sofy H. , Sánchez Rincón Juan D. , Guzmán-Porras Jennifer J. , López Mora Luisa F. , Ramírez Salazar Mateo H. , Ceballos Inga Leydi A. , Rueda Rodríguez María C. , Téllez Prada Hugo A. , Castro Rubio Juan C. , Lemus Espitia Ingrid , Guevara Ramos Juan D.
Published: May 2024

Cerebrospinal fluid opening pressure values are associated with various neurologic diseases; however, numerous factors can modify this measurement. This study aims to describe factors related to modifications in opening pressure measurements in pediatric patients. Methods: A retrospective analysis of lumbar punctures in pediatric patients conducted by the neuropediatrics group with institutional standardization. Bivariate and linear regression analyses were performed to determine the association between opening pressure and variables included in the study. Results: 544 events, median age 107 months, median opening pressure 19.7 cm H2O. Bivariate analysis found no association with medication use; anesthetics that increased opening pressure were remifentanil ( P = .02) and propofol ( P = .05), along with a positive linear correlation between opening pressure and age ( P < .0001). Multiple linear regression analysis revealed that age, BMI, male gender, and remifentanil use were associated with an increase in opening pressure, whereas corticosteroid withdrawal was associated with a reduction in opening pressure. There is an interaction between age and headache, with an association with increased opening pressure up to around 140 months. Conclusion: This study identifies factors associated with changes in opening pressure, crucial for estimating normal opening pressure values in children. Headaches, anesthetic use, and corticosteroid withdrawal are confirmed as significant factors.
Prospective Evaluation of the Peripheral Perfusion Index in Assessing the Organ Dysfunction and Prognosis of Adult Patients With Sepsis in the ICU
Authors: Guo Qirui , Lian Hui , Wang Guangjian , Zhang Hongmin , Wang Xiaoting
Published: May 2024

Background: The peripheral perfusion index (PI) reflects microcirculatory blood flow perfusion and indicates the severity and prognosis of sepsis. Method: The cohort comprised 208 patients admitted to the intensive care unit (ICU) with infection, among which 117 had sepsis. Demographics, medication history, ICU variables, and laboratory indexes were collected. Primary endpoints were in-hospital mortality and 28-day mortality. Secondary endpoints included organ function variables (coagulation function, liver function, renal function, and myocardial injury), lactate concentration, mechanical ventilation time, and length of ICU stay. Univariate and multivariate analyses were conducted to assess the associations between the PI and clinical outcomes. Sensitivity analyses were performed to explore the associations between the PI and organ functions in the sepsis and nonsepsis groups. Result: The PI was negatively associated with in-hospital mortality (odds ratio [OR] 0.29, 95% confidence interval [CI] 0.15 to 0.55), but was not associated with 28-day mortality. The PI was negatively associated with the coagulation markers prothrombin time (PT) (β −0.36, 95% CI −0.59 to 0.13) and activated partial thromboplastin time (APTT) (β −1.08, 95% CI −1.86 to 0.31), and the myocardial injury marker cardiac troponin I (cTnI) (β −2085.48, 95% CI −3892.35 to 278.61) in univariate analysis, and with the PT (β −0.36, 95% CI −0.60 to 0.13) in multivariate analysis. The PI was negatively associated with the lactate concentration (β −0.57, 95% CI −0.95 to 0.19), mechanical ventilation time (β −23.11, 95% CI −36.54 to 9.69), and length of ICU stay (β −1.28, 95% CI −2.01 to 0.55). Sensitivity analyses showed that the PI was significantly associated with coagulation markers (PT and APTT) and a myocardial injury marker (cTnI) in patients with sepsis, suggesting that the associations between the PI and organ function were stronger in the sepsis group than the nonsepsis group. Conclusion: The PI provides new insights for assessing the disease severity, short-term prognosis, and organ function damage in ICU patients with sepsis, laying a theoretical foundation for future research.
Backsliding versus Backlash: Do Challenges to Democracy in East Central Europe Threaten LGBTQIAP Empowerment?
Authors: O’Dwyer Conor
Published: May 2024

If third-wave democratization propelled gains in lesbian, gay, bisexual, transgender, queer, intersexual, asexual, and pansexual (LGBTQIAP) empowerment globally, does the contemporary wave of democratic backsliding imperil those gains? To what extent does the potential threat from such institutional erosion depend on the presence of right-wing populists in government, i.e., backlash? Can both threats be moderated by international pressure? Here, I present a theoretical framework for analyzing the interaction of backsliding, backlash, and international leverage as they impact LGBTQIAP empowerment. I then empirically probe this model’s plausibility by analyzing annual changes in LGBT empowerment through 2020 in fourteen new democracies in east central Europe. (The empirical analysis uses the narrower category “LGBT” because of data limitations.) I find that when neither backsliding nor backlash is present, LGBT empowerment expands regardless of international leverage. When both are present, however, international leverage is critical. If leverage is low, I find that LGBT empowerment declines, and the magnitude of losses in empowerment is greater than the magnitude of gains when neither is present. If leverage is high, simultaneous backlash and backsliding are associated with gains in LGBT empowerment. Even if the latter gains may be seen more as “pink-washing” than as sustainable and genuine change, these findings underline the importance of paying attention to international context when analyzing LGBTQIAP politics as the third wave ebbs.
How much can personality predict prosocial behavior?
Authors: Nielsen Yngwie Asbjørn , Pfattheicher Stefan , Thielmann Isabel
Published: May 2024

Explaining prosocial behavior is a central goal in classic and contemporary behavioral science. Here, for the first time, we apply modern machine learning techniques to uncover the full predictive potential that personality traits have for prosocial behavior. We utilize a large-scale dataset ( N = 2707; 81 personality traits) and state-of-the-art statistical models to predict an incentivized measure of prosocial behavior, Social Value Orientation (SVO). We conclude: (1) traits explain 13.9% of the variance in SVO; (2) linear models are sufficient to obtain good prediction; (3) trait–trait interactions do not improve prediction; (4) narrow traits improve prediction beyond basic personality (i.e., the HEXACO); (5) there is a moderate association between the univariate predictive power of a trait and its multivariate predictive power, suggesting that univariate estimates (e.g., Pearson’s correlation) can serve as a useful proxy for multivariate variable importance. We propose that the limited usefulness of nonlinear models may stem from current measurement practices in personality science, which tend to favor linearly related constructs. Overall, our study provides a benchmark for how well personality predicts SVO and charts a course toward better prediction of prosocial behavior.
Prognostic nomogram in middle-aged and elderly patients with chordoma: A SEER-based study
Authors: Ouyang Chenxi , Sun Yu , Li Yong , Jiang Ming , Nong Luming , Gao Gongming
Published: May 2024

Background

Chordoma is a bone tumor that tends to occur in middle-aged and elderly people. It grows relatively slowly but is aggressive. The prognosis of middle-aged and elderly patients with chordoma is quite different from that of young patients with chordoma.

Objectives

The purpose of the research was to construct a nomogram to predict the Individualized prognosis of middle-aged and elderly (age greater than or equal to 40 years) patients with chordoma.

Methods

In this study, we screened 658 patients diagnosed with chordoma from 1983 to 2015 in the Surveillance, Epidemiology, and End Results (SEER) database. We determined the independently prognostic factors that affect the survival of patients by univariate and multivariate Cox proportional hazards model. Based on the independent prognostic factors, we constructed a nomogram to predict the overall survival (OS) rates of middle-aged and elderly patients with chordoma at 3 and 5 years. The validation of this nomogram was completed by evaluating the calibration curve and the C-index.

Results

We screened a total of 658 patients and divided them into two cohort. Training cohort had 462 samples and validation cohort had 196 samples. The multivariate Cox proportional hazards model of the training group showed an association of age, tumor size, histology, primary site, surgery, and extent of disease with OS rates. Based on these results, we constructed the corresponding nomogram. The calibration curve and C-index showed the satisfactory ability of the nomogram in terms of predictive ability.

Conclusion

Nomogram can be an effective prognostic tool to assess the prognosis of middle-aged and elderly patients with chordoma and can help clinicians in medical decision-making and enable patients to receive more accurate and reasonable treatment.
Transitional Changes of Anxiety, Pain and Other Symptoms in Cancer Patients Admitted to a Palliative Care Unit, Evaluated Using the Support Team Assessment Schedule – Japanese Version
Authors: Ito Tetsuya , Tomizawa Emi , Yano Yuki , Akiyama Dai , Konishi Haruko , Takei Kiyozumi , Ikeda Masahiro , Takahashi Naoko , Shaku Fumio
Published: May 2024

Objective: Association between physical symptoms and psychosocial difficulties of cancer patients has been reported widely. Nevertheless, the effects of pain and other symptom control on anxiety in such patients have not been investigated well. We investigated the association of improvement of pain and other symptoms with patient anxiety, and assessed factors associated with improvement of such symptoms. Methods: Data of patients with advanced cancer admitted to a palliative care unit during August 2018 – June 2022 were analyzed retrospectively. Severity of pain, other symptoms, and anxiety was assessed by the Support Team Assessment Schedule Japanese version (STAS-J) administered at admission and after 2 weeks. Patients’ physical data, their Palliative Prognostic Index (PPI) at admission, and their overall survival were collected and recorded. Results: Data of 701 patients were analyzed. Improvement of pain or other symptoms after 2 weeks was not associated with the PPI total score or actual survival ( P = .105 and .999). Patients with higher anxiety on admission experienced improvement of pain or other symptoms more frequently ( P = .005). Worsening of anxiety was observed less in patients who experienced improvement in pain or other symptoms after 2 weeks ( P = .027). Conclusion: Pain or other symptoms of patients with advanced cancer was improved irrespective of the general condition indicated with actual survival and prognosis-predictive factors. These findings suggest the importance of pain and other symptoms’ improvement and its important roles in the management of patient psychosocial problems such as anxiety.
A modified Manson-Halford model based on improved WOA for fatigue life prediction under multi-level loading
Authors: Yang Yibo , Zou Li , Cao Xinyu , Yang Xinhua , Sun Yibo
Published: May 2024

The Manson-Halford (M-H) nonlinear cumulative damage model is widely applied for fatigue life analysis problems under multi-level loading. In this model, the influence of loading sequence on the fatigue life can be better considerer, but the loading interaction effect is ignored. An improved whale optimization algorithm (IWOA) by integrating multiple strategies is proposed. The ability of global search and local exploitation is balanced and improved through nonlinear convergence factor, adaptive weighting factors and the Cauchy reverse learning strategies. In order to fully account for loading interaction effect, loading weighting factors are introduced to modify the M-H model, and the parameters are optimized through the global search properties of IWOA. The model is evaluated on multi-level loading fatigue experimental data from five metal materials and two aluminum alloy welded joints. The results suggest that the proposed IWOA has better optimization accuracy compared to the standard whale optimization algorithm (WOA). The proposed modified M-H model has better prediction performance compared to the four traditional cumulative damage models, which can be effectively applied to multi-level loading fatigue life analysis problems under actual working conditions. The proposed model is useful for the study of fatigue life evaluation methods.