bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase Ib/II Study of Lacnotuzumab in Combination with Spartalizumab in Patients with Advanced Malignancies
Authors: Ahmed Jibran , Stephen Bettzy , Yang Yali , Kwiatkowski Evan , Ejezie Chinenye Lynette , Pant Shubham
Published: November 2023

Introduction

Blocking the colony-stimulating factor 1 (CSF-1) signal on tumor-associated macrophages can lead to an upregulation of checkpoint molecules, such as programmed cell death ligand 1 (PD-L1), thus causing resistance to this blockade. Combining spartalizumab (PDR001), a high-affinity, ligand-blocking, humanized anti–PD-1 immunoglobulin G4 antibody, with lacnotuzumab (MCS110), a high-affinity, humanized monoclonal antibody directed against human CSF-1 can potentially overcome this resistance.

Methods

This was a multicenter, phase Ib/II trial using a combination of spartalizumab with lacnotuzumab in patients with advanced cancers, including anti–PD-1/PD-L1 treatment-resistant melanoma, and anti–PD-1/PD-L1 treatment-naïve triple-negative breast cancer, pancreatic cancer, and endometrial cancer (ClinicalTrials.gov identifier: NCT02807844). The primary objective of dose escalation phase Ib was to assess safety, tolerability, and recommended phase II dose. The primary objective of the phase II expansion study was to assess the combination’s antitumor activity, including objective response rate and clinical benefit rate.

Results

A total of eight patients (five in phase Ib and three in phase II) were evaluable for adverse events (AEs) at our study site. All eight patients experienced at least grade 1 AE. The most common treatment-related AEs were increased serum aspartate aminotransferase (38%), fatigue (38%), anemia (25%), increased alkaline phosphatase (25%), hyperbilirubinemia (25%), hypocalcemia (25%), and hypoalbuminemia (25%). Most of these AEs were grade 1 or 2. None of the patients experienced grade 4 AEs and no drug-related fatal AEs were reported among the eight patients treated in the study. One (13%) patient had stable disease (SD) (captured as unknown by the study sponsor because the evaluation criteria set per protocol was not met) and three (38%) patients had progressive disease. Four (50%) patients developed clinical disease progression based on investigator evaluation. One patient with pancreatic cancer achieved immune-related SD for 26 months while on the study treatments.

Conclusion

The study completed phase Ib dose escalation and phase II. However, gating criteria for efficacy were not met for expansion beyond 80 patients in phase II and the sponsor did not continue development of the combination of spartalizumab and lacnotuzumab for oncology indications. The potential signal of activity in pancreatic cancer should be further explored.
Examination of re-admission and causes with pain patients in the emergency department
Authors: Güven Oya , Nazlı Ünkazan Fatma
Published: November 2023

Objective: Pain is an essential symptom in emergency department admissions, but few studies have focused on its effect. This study aimed to determine the admission rates of patients with a pain diagnosis and to evaluate the rate of re-admissions to the emergency service within one month. Also, this patient group will determine the reasons for returning to the emergency department by examining the emergency service data of the only hospital in the city centre and the largest in the province.
Material and Methods: In this study, patients who presented to the emergency department with a complaint of musculoskeletal pain between January 1 and December 31, 2021, and entered the R52, M25, M54, and M79 ICD codes (and their subgroups) as a diagnosis into the system were selected. Patients were classified as traumatic/non-traumatic (patients who requested extremity radiography or tomography were considered traumatic). The files were retrospectively scanned to determine the treatments administered to specific patients in the emergency department. It was investigated whether these patients subsequently sought treatment in the relevant branches, such as neurosurgery, orthopedics, or physical medicine and rehabilitation outpatient clinics, within one month. Furthermore, the patients' re-admission to the emergency service within one month were examined.
Results: A total of 1742 patient files were included in the study. 50.8% of the patients were male, and the mean age was 41.9±17.3. It was determined that 1407 patients (80.8%) were treated in the emergency department, and the highest rate (61.2%) was intramuscular (IM) injection. The rate of going to the outpatient clinic was 17.6%, and the mean time of being examined was 2±5.4 days. It was observed that 30.4% of the patients were admitted to the emergency department again. The patients were divided into two groups according to whether they had a history of trauma or not. The ratio of male patients was higher in both groups (p>0.05), and the mean age of patients with trauma was lower (35±18.6). The rate of re-admission to the emergency department of the patients without trauma was significantly higher than the other group (p<0.05). The rate of being examined in the relevant polyclinic was higher in the group without trauma (17.8%).
Conclusion: This study found a high admission rate to the emergency department for patients presenting with pain complaints. Furthermore, there was a notable high re-admission rate among patients without trauma following outpatient clinic examinations. It is evident that achieving effective pain control for these patients may require a significant amount of time. The recurrent emergency admissions may be attributed to persistent pain complaints
Workload with Documentation Nursing Care in the Patient Room
Authors: Situmorang Benny Harry Leksmon , Siauta Viere Allanled , Puspitasari Elin , Hutagaol Iin Octaviana
Published: November 2023

Nursing documentation is part of a record action of accurate written evidence carried out by nurses during nursing activities high workloads can affect complete nursing documentation. The purpose of the research was to analyze the relationship of the workload with the documentation of nursing care in the nursing room in RSUD Tora Belo District Sigi. This research was a quantitative study with a cross sectional approach. The population was a cement and ebony nurses with a total of 34 subjects. Research tools for this research were the workload questionnaires and document observation panel. The sampling technique used is the total sampling technique. Its free variable was a workload and its bonded variable was a data analysis document used spearman test. Univariat result obtained heavy workload of 18 subjects 52,9 %, incomplete care record of 31 subjects 91,2 %. Two variable analysis shows that there's a workload link with a nursing system in the hospital in RSUD Tora Belo District Sigi which was p-value=0,035 (p-value<0,05). While correlation value of 0,36 indicated a medium relationship with positive correlation value. The conclusion of this study is that there's a workload link to the documentation of nursing care in the nursing room in RSUD Tora Belo District Sigi.
A MINI-REVIEW ON Musanga cecropioides R. Br. ex Tedlie
Authors: Goddidit Esiro Enoyoze  , MacDonald Idu
Published: November 2023

Musanga cecropioides R. Br. ex Tedlie (family Urticaceae) is a tree distributed across some parts of Africa including Nigeria. Ethnomedicinal surveys of Musanga cecropioides implicate that its various parts are used in the management of several health conditions asides the numerous uses reported ethnobotanically. This review was thus aimed at assessing the extent of work done on Musanga cecropioides parts scientifically in order to identify the gaps that exist in literature. The review revealed the widespread application of Musanga cecropioides parts in the management of cough, diabetes and several other illnesses with little or no scientific work carried out to validate such claims.
KEYWORDS: Musanga cecropioides, ethnobotany, ethnomedicine, characteristics and properties.
Economic stability and ways to strengthen the security of enterprises in the face of modern challenges
Authors: Sadura Oksana B. , Pravdyvets Oleksandr M.
Published: November 2023

Achieving economic stability is one of the main challenges facing businesses in today’s unstable financial and political environment. The coordinated development and creation of a reliable and promising business climate are among the top priorities for Ukraine’s economy, which would ensure the continued functioning of business entities in the future. The article aims to analyze the economic stability of enterprises in the context of modern challenges, namely during martial law in Ukraine, and outline the main directions for strengthening the security of enterprises. The basic essence of the term “economic stability of an enterprise” is revealed, taking into account the interpretation of this concept in the scientific works of economists. The article analyzes the economic stability of enterprises in the context of modern challenges, namely, during martial law in Ukraine. It emphasizes that in addition to profitability, the economic stability of an enterprise depends on many factors that are formed as a result of financial stability and economic and financial resilience. The full-scale invasion of our country by the Russian aggressor has made adjustments to the economic stability of enterprises. The authors analyze the main problems that prevent businesses from recovering and developing during the war and point out certain conditions to which enterprises are adapting. The positive aspects on the basis of which the economic activity of enterprises is gradually recovering in certain industries are outlined. The results of the analytical report of the United Nations Development Programme in Ukraine are analyzed, and the directions for strengthening the security of enterprises in the context of modern challenges are offered.
Prospects for the development of the innovative potential of agricultural enterprises
Authors: Zhevatchenko Vitaliy S.
Published: November 2023

The article substantiates the feasibility of the introduction of innovative technologies in agricultural production. Scientific and technological progress promotes the introduction of modern systems in the activities of agricultural enterprises to increase their efficiency. The conditions necessary for the development of the innovative potential of business entities are outlined. The advantages that enterprises will receive through the use of digital processes are described. The problems that delay the implementation of innovations are identified: imperfect network coverage, poor mastering of computer programs by employees, lack of a single online platform, and standardization and compatibility of technologies for data exchange. Features of the Marketplace electronic platform are described, where cooperation between agricultural producers and consumers of agricultural products takes place without intermediaries. The expediency of creating a single information space of agribusiness for the purpose of information support for agricultural producers is substantiated. The article emphasizes that agribusiness successfully applies innovative new products, including complex management of equipment, system accounting of fuel, accounting of work performance, and accurate and intelligent farming. It also reveals that the application of Big Data is an important step in the systematic digitization of data, with the help of which agricultural enterprises can accumulate important information on how to conduct manufacturing and sell their products and services on the market. The authors suggest the application of Blockchain technology, which will make it possible to control the origin, quality, and environmental friendliness of agricultural raw materials and food, and will also create a significantly higher level of trust in the agricultural sector. The introduction of innovative technologies in agricultural enterprises will provide an opportunity to increase labor productivity, improve the quality of management, and accelerate the automation of production processes, which in turn will make agribusiness attractive for investment.
The Implementation Of Using English Movie For Improving The Students' Pronunciation At The Eleventh Grade Of SMA YAYASAN PERGURUAN KELUARGA Pematangsiantar
Authors: Purba Bennarita , Nur Hkairah Annisa
Published: November 2023

The aim of this research was to find out whether the implementation of using English movie effective for improving the students' pronunciation at the eleventh grade of SMA Yayasan Perguruan Keluarga Pematangsiantar in the academic year 2021/2022. This research used quantitative approach with true experimental research design. This research used saturated sampling as a technique to choose the sample and the sample of this research was 60 students. The instruments of this research were pre-test, post-test and recording. The data were taken from score of pre-test and post-test. The technique of collecting data in this research is using an oral test. The data of pre-test and post-test of both groups were analyzed by using SPSS 26.0. The result of the research shows that the testing hypothesis of post-test scores was found that the mean of post-test experimental class is 72.60 from 30 students with standard deviation 6.240 and standard error mean 1.139. Meanwhile, mean of post-test control class is 68.33 from 30 students with standard deviation 6.825 and standard error mean 1.246. And then, fcount = 6.387 > ftable = 4.01 at significance level α = 0.014 with degrees of freedom (df) = 43, it means that Ha is proven to have a significant effect in improving students' pronunciation. Then, tcount = 3.305 and ttable = 1.699. So, tcount = 3.305 > ttable = 1.699 at the significance level α = 0.05 with degrees of freedom (df) = 29. So, Ho is rejected and Ha is accepted. It means that, the implementation of using English movie effective for improving the students' pronunciation at the eleventh grade of SMA Yayasan Perguruan Keluarga Pematangsiantar
The Influence Of The Ability In Mastering Dialogue On Students Speaking Comprehension At SMP SWASTA CINTA RAKYAT 3 Pematangsiantar
Authors: Purba Ridwin , Samosir Willy Febrianto
Published: November 2023

The aim of this research was to find out the influence of the ability in mastering dialogue on students speaking comprehension at SMP SWASTA CINTA RAKYAT 3 PEMATANGSIANTAR in the academic year of 2021/2022. This research was classified as a true-experimental study. It involved 24 students from two groups, as the experimental group (12 students) and as the control group (12 students). The experimental group was students taught using picture sets dialogue where as the control group was students taught using lecture technique. The data were obtained by using pre-test and post-test. The data of the pre-test and post-test of both groups were analyzed by using descriptive and inferential statistic. (SPSS 22.0). The result of the research shows that the testing hypothesis of post-test score, it is found that tcount (9,326) > ttable  (8,233) at the significance level a = 0.05 and degrees of freedom (df) = 11. H0 is rejected and Ha is accepted. So, it means that the influence of the ability in mastering dialogue significantly on students speaking comprehension at SMP SWASTA CINTA RAKYAT 3 PEMATANGSIANTAR academic year of 2021/2022
ANALYSIS OF SHARIA MARKETING MIX AND SERVICE QUALITY TOWARDS CUSTOMER SATISFACTION AT GRESIK VIVI DRINKING WATER REFILLING STATION
Authors: Malik Ahmad Dahlan
Published: November 2023

This research is conducted to help customers in delivering the complaints in the form of product quality and the way of providing services of the subject research and the improvement of it using sharia marketing mix perspectives and service quality. This research is a quantitative study using the Partial Least Squares (PLS) method. The data collection method comes from primary data of distributing questionnaires to 126 respondents of Gresik Vivi Drinking Water Refilling Station customers. The results of this study indicate that product quality (X1), Price (X2) and Promotion (X4) have no significant effect on customer satisfaction (Y) and in the other words those variables need to be high concern of the owner of business to handle the improvement or handling the customer complaints. Meanwhile, the location (X3) and the service quality (X5) have a significant effect. This is indicated that those variables are more suitable for the customer satisfaction and need to be maintained by the owner in developing the business.Â
Hybrid azole-based conjugates as upcoming anticancer and antimicrobial agents
Authors: Frija Luís M. T. , Guerreiro Bruno E. C. , Costa Inês C. C. , Isca Vera M. S. , Saraiva Lucília , Neves Beatriz G. , Magalhães Mariana , Cabral Célia , Cristiano Maria L. S. , Rijo Patrícia
Published: November 2023

Aim: This study discloses the synthesis and the antimicrobial and anticancer activities of four molecules of structural basis saccharin-thiadiazolyl (4), saccharin-pyridyl (6, 8), and tetrazole-thiadiazolyl (11). Methods: Antimicrobial properties of the molecules were evaluated by the well-diffusion method, against Gram-positive bacteria [Staphylococcus aureus American Type Culture Collection (ATCC) 25923, Staphylococcus epidermidis ATCC 12228, Mycobacterium smegmatis ATCC 607], Gram-negative bacteria (Pseudomonas aeruginosa ATCC 27853) and yeast (Saccharomyces cerevisiae ATCC 2601 and Candida albicans ATCC 10231) strains. The anticancer activity of the compounds was assessed through i) proliferation assays for HCT116, MCF-7, and A375 human cell lines [cells were treated with serial dilutions of compounds and the effect on cell propagation was evaluated by sulforhodamine B (SRB) assay]; ii) antiproliferative and cytotoxic assays for glioma-type cell lines A172 (glioblastoma), U87 (brain-likely glioblastoma), and H4 (neuroglioma; cells were treated with diverse concentrations and the cell viability was assessed using a modified Alamar blue® assay). Results: Compound 11 exhibited significant inhibitory activity against S. aureus and S. epidermidis, with the further molecules demonstrating some inhibitory potential against all the tested Gram-positive, Gram-negative, and yeast strains. Similarly, derivative 11 showed an interesting antiproliferative activity against human colon adenocarcinoma (HCT116), human breast adenocarcinoma (MCF-7), and melanoma (A375) cells, with 50% growth inhibition (GI50) values varying from 3.55 µmol/L to 11.5 µmol/L, in the same order of magnitude of those shown by etoposide. Treatment of brain-like glioblastoma cells (U87) with 11, at the concentration of 100 µg/mL, induced a decrease in cell viability by 50% after 48 h and 72 h. Besides, results attained for A172 cells have shown that compound 11 only induces a significant decrease in cell viability upon treatment at 100 µg/mL for 72 h. A divergent observation was recorded for H4 cells, where the treatment with derivative 11 had promoted a significant decrease in cell viability (< 40–60%), even at concentrations as low as 0.39 µg/mL, after 24 h. Conclusions: This investigation reveals the potential of distinct azole-based conjugates, in particular the tetrazole-thiadiazolyl (11) derivative, as scaffolds worth further investigations, in the frame of antimicrobial and antineoplastic chemotherapy.
PARTICIPATION IN BODA BODA OPERATIONS AND ACADEMIC PERFORMANCE: THE CASE OF STUDENTS IN PUBLIC DAY SECONDARY SCHOOLS IN UGUNJA SUBCOUNTY, KENYA
Authors: Oyugi Joash Onyango , Amunga Jane , Masinde Joseph
Published: November 2023

Education is a critical component of social and economic growth in any society. Many countries worldwide strive to provide quality education to their citizens. However, the high cost of education makes some countries only offer partial financial support to education at the secondary school level. This has consequently led to increased pressure on economic and other resources as individuals strive to meet the other education costs. Students in developing countries participate in activities such as Boda Boda Operations as alternative ways to finance their education. This research sought to establish the relationship between students' participation in Boda Boda Operations and their academic performance in public day secondary schools in Ugunja sub-county, Kenya. The objective of this study was to establish the relationship between students' participation in Boda Boda operations and their academic performance in public day secondary schools in Ugunja Sub-County, Kenya. Social conflict theory was used as a basis for this research. A descriptive survey research design was used to execute the study. The target population was the 1498 students in public day secondary schools within the research area who participated in Boda Boda operations regularly. The sample comprised 306 respondents, who were selected by snowball sampling technique. The data was collected using two instruments; a questionnaire for independent variables and a document analysis guide for the dependent variable. Data were analyzed descriptively using means, standard deviations, and percentages. The hypothesis was tested inferentially at a 0.05 alpha level of significance using Bivariate Pearson's Correlation. The r values Boda Boda Operations was -0.809. Results revealed a significant negative relationship between the Boda Boda operations the sampled students engaged in and their academic performance in the study area. It is recommended that The Ministry of Education should increase capitation towards funding for public day secondary school education so that students from poor backgrounds do not absent themselves from school to engage in BBO for purposes of financing their education, as this negatively affects their academic performance.
APPLICATION OF AUGMENTED VIRTUAL REALITY TECHNOLOGY IN TEACHING CHEMISTRY IN HIGH SCHOOLS
Authors: Duc Nguyen Mau , Huu Pham Tien , Tuoi Tran Thi , Khanh Ngo Gia , Bao Khanh Le Dang , Huong Vu Hai
Published: November 2023

With the robust development of the fourth industrial revolution and advancements in the field of educational science due to the integration of technology with education, Augmented Reality (AR) stands out as a promising tool for enhancing learning experiences. AR offers significant potential and numerous essential benefits in teaching and learning processes, thanks to its interactive and visual nature. This article focuses on introducing AR and outlining designs as well as proposing chemistry lesson contents integrated with AR in three formats: providing knowledge to learners; constructing hypothetical situations, simulating processes; and assessment and evaluation. By leveraging AR, we encourage students' proactive engagement and foster an interest in chemistry by making the learning experience more immersive and hands-on. AR allows students to manipulate virtual objects and conduct experiments in a safe and controlled environment, enhancing their understanding of complex chemical concepts. The potential and benefits that AR brings have facilitated groundbreaking advancements in teaching and learning at the general education level.
ASSESSMENT OF THE CRAFT AND ENTREPRENEURSHIP MODULE WITH ONLINE MARKETING LEARNING FOR SENIOR HIGH SCHOOL
Authors: Mildayani Winda , Murtini Wiedy , Sudarno
Published: November 2023

This study aims to describe the results of the assessment of the craft and entrepreneurship module with online marketing learning made by researchers and then will be assessed by expert validators to determine the eligibility of the module. The feasibility of this media was assessed by two validators (media experts and material experts). In the data collection, the researcher used a product evaluation questionnaire instrument which is used by expert validators. The results show that the module with online marketing learning is good for craft and entrepreneurship learning media with the results of the media expert's assessment is 85%, the material expert's has a 85% and the total result of the media expert's and material expert's scored by 85.41%.
RESEARCH ON THE PATH OF HIGH-QUALITY CULTIVATION OF DIGITAL LITERACY FOR THE ELDERLY IN THE DIGITAL ERA——TAKING HAINING, ZHEJIANG AS AN EXAMPLE
Authors: Wu Huabin , Fu Yifan , Hong Jiayu
Published: November 2023

With the arrival of the digital era, how to resolve the contradiction between the digitization of life and the aging of society, and to help the high-quality cultivation of digital literacy of the elderly has become an imminent problem. Taking the elderly in Haining City as the research object, we found that the cultivation of digital literacy of the elderly in Haining City is facing a number of problems through investigation and research, and then on this basis, we propose that the government needs to give full play to its leading role and actively establish a lifelong education system; build a dual learning channel online and offline; open a specialization in education for the elderly in cooperation with the school and the local community; and the family and the society need to enhance the strength of the digital feedback to build a good atmosphere of learning for the elderly, etc. The paths are as follows. In order to provide practical suggestions for the high-quality cultivation of digital literacy of the elderly in Haining City.
INFLUENCE OF MASTERY LEARNING STRATEGIES AND STUDENT MOTIVATION ON ARGUMENTATIVE WRITING OUTCOMES IN 11TH GRADE AT SMK NEGERI 5 MAUK
Authors: Toyibah
Published: November 2023

This study aims to (1) explore the difference in argumentative writing outcomes among students with high learning motivation taught using mastery learning strategy compared to expository strategy; (2) investigate the difference in argumentative writing outcomes among students with low learning motivation taught using mastery learning strategy versus expository strategy; (3) analyze the interaction between mastery learning strategy and students' learning motivation on argumentative writing outcomes. Conducted at SMK Negeri 5 Mauk, Tangerang Regency, Banten Province, during the 2010-2011 academic year, the research included 160 11th-grade students majoring in Computer Engineering. The study selected a sample of 48 students using a gradual random sampling method. Data collection involved questionnaires to assess learning motivation, validated through the Person Product Moment formula, and reliability evaluated using Cronbach's Alpha. Out of 40 questionnaire items, 30 were deemed valid with a reliability coefficient of 0.915. Additionally, a writing test assessed argumentative writing outcomes, with 30 out of 40 items showing good validity and a reliability coefficient of 0.9625. These research findings hold significant implications for educational policy development, particularly concerning the enhancement of students' learning outcomes.
SUSTAINING THE FUTURE: AN EXPLORATORY STUDY ON INNOVATIVE CARBON REDUCTION TECHNOLOGIES IN EMERGING ECONOMIES LIKE INDIA
Authors: Bhatia Uday
Published: November 2023

Sustainable development and protecting the environment are extremely important in the world today. The situation demands a collective effort by all nations of the world to come up with a viable solution. This involves labeling environmentally friendly goods as ‘World Public Goods’ and the importance of financing from both the public and the private sectors.
Implementing a District-Wide, Multi-Tiered Instructional Improvement System to Address Persistent Student Learning Performance Gaps through Developing Teachers’ Authentic Data Teaming Capacities
Authors: G. Claudet Joseph
Published: November 2023

Instructional improvement leaders in many school districts across the United States have become stymied in how to properly address the substantial learning performance deficiencies demonstrated by the growing numbers of diverse, at-risk learners entering their districts and populating their campuses and classrooms. This article examines how one assistant superintendent and her instructional improvement task force colleagues working in a high diversity urban school district employed design research investigative thinking and innovative professional development strategies derived from the education improvement science literature to implement a comprehensive intervention program for educators in elementary and secondary schools throughout the district to revitalize classroom teachers’ and their campus-based instructional supervisors’ instructional data teaming practices to better serve the academic learning support needs of the district’s large numbers of diverse, at-risk students. Key features of the design-based approach to turnaround instructional improvement presented and discussed in this case study report include: 1) leveraging the power of immersive professional learning to provide educators with multiple opportunities to critically examine their own, often ingrained, deficit thinking pedagogical mindsets regarding the motivation levels and learning potentials of at-risk students; and 2) assisting educators in learning how to engage together in authentic data teaming and data analysis–informed differentiated instructional planning to craft high-engagement classroom teaching and learning environments for all diverse learners. A set of design principles derived from the case study is also presented that may be of practical use to instructional improvement leaders working in a variety of school district settings interested in exploring the potential of design-based intervention methods for addressing the learning development and support needs of diverse, at-risk learners.
Editorial
Authors: Seco Ricardo Francisco
Published: November 2023

Con mucha alegría presentamos nuestra revista. Esta vez es la quinta edición de la Revista de Estudio de Derecho Laboral y Derecho Procesal Laboral. Ella es elaborada por la Sala de Derecho Laboral y Derecho Procesal Laboral que funciona en el marco del Instituto de  Investigación en Ciencias Jurídicas (IDICJ) de la Universidad Blas Pascal de la ciudad de Córdoba, en la República Argentina.
La prueba de las relaciones laborales informales
Authors: Lois Sergio
Published: November 2023

Sumario: I. Introducción. II. La dependencia. III. La ajenidad. IV. Cuestiones probatorias en torno a la acreditación de las relaciones de trabajo. V. La prueba del contrato de trabajo. VI. La prueba testimonial. VII. La prueba confesional. VIII. Las presunciones y la acreditación del vínculo laboral. IX. La presunción del art. 23 de la LCT. X. Presunción del art. 55. Obligación de declarar si los libros son llevados en legal forma. XI. Presunción del art.57 de la LCT. XII. Los indicios. XIII. El haz de indicios. XIV. Carga dinámica de la prueba. XV. Principio de primacía de la realidad. XVI. Los ambientes de trabajo y la tecnología
Estrategias en Seguridad Pública y su Impacto en el Ámbito Económico
Authors: Sánchez Méndez Luis Germán , Quintal García Nancy Angelína , Ganzo Olivares Jacqueline
Published: November 2023

La función de la promoción de la seguridad pública desempeña rol esencial que fortalece el respaldo del desarrollo de la economía y en al ámbito social. Conforme a que la policía realice su labor de manera eficiente, se identificará una percepción social adecuada y se presentarán alternativas claras y objetivas que garanticen el desarrollo económico del entorno. Por lo anterior, este estudio se centró en examinar las tácticas desarrolladas por los empresarios de Chetumal con el fin de potenciar el rendimiento de las iniciativas de protección ciudadana, con la meta de impulsar el progreso económico y el bienestar en la localidad, se enfoca en la determinación de escenarios adecuados para el fomento económico en un entorno donde la seguridad esté garantizada y que exista confianza en los cuerpos policiales, lo cual, a partir de un estudio etnográfico, se entrevistaron a diversos comerciantes de la capital del estado para conocer su percepción respecto a la seguridad y sus aportaciones para la definición de estrategias relevantes, donde el fomento a la colaboración, el enfoque de prevención, el mejoramiento de infraestructura y la promoción de la participación ciudadana fueron los pilares sustanciales en las aportaciones que brindaron viabilidad para la definición de las propuestas determinadas en esta indagatoria.
El Estrés Factor Socioemocional Influyente en el Desempeño Laboral Docente del Nivel Inicial y Preescolar en la Ciudad de México
Authors: Morales López Joaquín , Gómez Molina Israel Antonio
Published: November 2023

Existe el factor socioemocional estrés presente en todos los ámbitos laborales a nivel mundial. El objetivo de esta investigación es evaluar este factor social emocional para identificar las repercusiones en el desempeño laboral en el campo de la educación inicial y preescolar, en el área conurbada de la Ciudad de México. Se toman en cuenta estudios previos tanto internacionales como nacionales, los cuales se centran en la prevención de los factores psicosociales, abordando la integración de la promoción de la salud en las políticas y acciones en materia de seguridad y salud laboral a nivel de empresa. La presencia del virus del Covid 19 y la pandemia se han relacionado con el incremento del estrés en el personal docente. El diseño de la metodología de investigación permitió generar las bases de datos para determinar la presencia del estrés en sus diferentes grados y orígenes, el factor psicológico es el más concurrente, el factor social es el que sigue en la escala de incidencia y los factores físicos con una menor presencia, se puede establecer que hay una repercusión negativa en el desempeño laboral y las buenas prácticas educativas, por consiguiente, se ve afectada la calidad de servicio.
Penerapan Model Regresi Linear Untuk Estimasi Mobil Bekas Menggunakan Bahasa Python
Authors: Arif Mohamad , Faisal Muhammad
Published: November 2023

Used cars have a significant transaction value in the automotive market. Estimating the price of a used car is important for buyers and sellers to determine the appropriate value. In this study, we apply a linear regression model using the Python programming language to estimate the price of a used car based on relevant attributes such as year of production, mileage, car tax, fuel consumption, and number of engines. We use a used car dataset that contains important information for analysis. In using the linear regression model in this study, it was successful in obtaining an accuracy of 0.76% and the results for estimating car prices were obtained by inputting car year = 2019, car mileage = 5000, car tax = 145, fuel consumption = 30,2, and engine size = 2. Then managed to get an estimated value of 21.208,505 in Pounds and 393.608,6514549 in Rupiah units. So that it can be said that the Linear Regression model has proven successful in the good category for finding used car price estimates based on certain factors using python language.
Analisis Sensitivitas Model Goal Programming Pada Optimasi Produksi Roti Menggunakan Metode Branch and Bound
Authors: Ahmad Rindawati , Katili Muhammad Rifai , Mahmud Sri Lestari , Wungguli Djihad , Nashar La Ode
Published: November 2023

Sya'qila Bakery is a manufacturing industry that produces bread in five flavor variants. The planning carried out by Sya'qila Bakery in the bread production process is considered suboptimal due to the limitation in the quantity of production for each flavor variant, resulting in occasional shortages of raw materials. Additionally, the order production process requires a long total completion time (makespan), resulting in delays in production completion (meaning tardiness). This research aims to optimize the total completion time, the average lateness, the use of raw materials, and production revenue. In this research, the Goal Programming model is utilized with the Branch and Bound method. The analysis results with the Goal Programming model using the Branch and Bound method obtain an optimal solution, which includes an excess of 36 minutes in total completion time (makespan), an excess of 6 minutes in average lateness (mean tardiness), no excess in the availability of raw materials, and zero sales revenue shortfall. Sensitivity analysis results indicate that bread production at Sya'qila Bakery will remain optimal if changes occur in the production completion time, production delay time, and raw material availability, as long as these changes remain within their tolerance limits.
Combining Handcrafted Features and Deep Learning for Automatic Classification of Lung Cancer on CT Scans
Authors: Deshpande Pallavi , Bhatt Mohammed Wasim , Shinde Santaji Krishna , Labhade-Kumar Neelam , Ashokkumar N. , Venkatesan K. G. S. , Shadrach Finney Daniel
Published: November 2023

On a global scale, lung cancer is responsible for around 27% of all cancer fatalities. Even though there have been great strides in diagnosis and therapy in recent years, the five-year cure rate is just 19%. Classification is crucial for diagnosing lung nodules. This is especially true today that automated categorization may provide a professional opinion that can be used by doctors. New computer vision and machine learning techniques have made possible accurate and quick categorization of CT images. This field of research has exploded in popularity in recent years because of its high efficiency and ability to decrease labour requirements. Here, they want to look carefully at the current state of automated categorization of lung nodules. General-purpose structures are briefly discussed, and typical algorithms are described. Our results show deep learning-based lung nodule categorization quickly becomes the industry standard. Therefore, it is critical to pay greater attention to the coherence of the data inside the study and the consistency of the research topic. Furthermore, there should be greater collaboration between designers, medical experts, and others in the field.
Stochastic Analysis of Markov Chain In Finite State: Empirical Evidence on Nigerian Current Account Net Movements
Authors: UCHENNA Amadi Innocent , UCHECHI Ahana , ELE Chims Benjamin
Published: November 2023

Purpose: The Current Account is an essential indicator of an economy's speed. It is because it is defined as the sum of trade balance, net income from abroad, and net current transfers. Therefore, the impression of the Markov chain is a viable instrument for investigating the Nigerian Current Account (NCA) formation in finite since each finite state interconnects for suitable decision-making. Thus, this dissertation studied the stochastic analysis of the Markov chain on NCA data (2004-2022).Methodology:The NCA data were transformed into a 3-step transition probability matrix solution to cover independent years. The future NCA data changes were known by introducing a time interval of three years as row vectors.Findings: The solution matrix of the stochastic analysis showed that 2004-2012 has the highest probability of reducing payments by 72%, the year 2005-2013 has the highest probability of reducing by 66%, and finally, 2014-2022 has the highest probability of no-change in payments of goods and services by 3.3%.Implication:Finally, other statistical variations were also considered and discussed in this paper. All this informs the Nigerian economy on the proper way to make vital decisions effectively and are hopeful for future investment plans both short and long term respectively.
The Concept of the Immortality of the Soul: A Biblical-Theological Study
Authors: Danquah Joseph
Published: November 2023

The concept of the immortality of the soul, as held by pagans, has been the subject of extensive scholarly research over the years. Despite concerted efforts to disprove the idea of life after death, the doctrine remains a theological enigma. This research thus delved into the immortality of the soul as depicted in the Bible. The study posited that the body and soul are not distinct entities but rather integral components of the human person. The Bible does not recognize a separate existence of the body and soul after death, instead, it regards them as an inseparable unity that ceases to exist until the resurrection. Consequently, the elements that make up a person and the process described in Genesis 2:7 do not involve the existence of a soul in the dualistic sense. The Bible maintains that no division between the body and soul occurs independently at the time of death. Thus, the doctrine of the immortality of the soul lacks biblical support. The study, employing a biblical-theological approach, sought to address the prevailing debates concerning the concept of the “immortality of the soul.” This paper argues for the belief in the immortality of the soul and posits that it is not consistent with biblical teachings. The study suggests that this belief may have originated from the Edenic teaching that humans “shall not surely die.” (Gen. 3:4).

Keywords: Immortality of the Soul, Biblical Theological Study, Religious Belief Systems, Doctrines
Franco-American Newspapers and Periodicals in the Northeast: An Inventory
Authors: Albert Jacob , Pinette Susan
Published: November 2023

Franco-American newspapers and periodicals occupy an overlapping space between primary and secondary literature, and their shadow looms large over the collective body of historic Franco-American sources. Their significance to the Franco-American community is hard to overstate. These periodical publications complicate issues of identity in the U.S. Northeast and are an integral part of Québec history itself. This article details current work to inventory newspaper and periodical titles (currently over 400) and makes accessible our collectively built, evolving inventory of Franco-American newspapers.
Broadband X-Ray Timing and Spectral Characteristics of the Accretion-powered Millisecond X-Ray Pulsar MAXIJ1816-195
Authors: Li Zhaosheng , Kuiper Lucien , Ge Mingyu , Falanga Maurizio , Poutanen Juri , Ji Long , Pan Yuanyue , Huang Yue , Xu Renxin , Song Liming , Qu Jinlu , Zhang Shu , Lu Fangjun , Zhang Shuang-Nan
Published: November 2023

We studied the broadband X-ray timing and spectral behaviors of the newly confirmed accreting millisecond X-ray pulsar MAXI J1816−195 during its 2022 outburst. We used data from the Insight-HXMT Medium Energy (ME) and High Energy (HE) telescopes, NICER, and NuSTAR that cover the energy range between 0.8 and 210 keV. A coherent timing analysis of solely the Insight-HXMT HE data across the full outburst revealed a complex behavior of the timing residuals, also prominently visible in the independent Insight-HXMT ME and NICER data, particularly at the rising part of the outburst and at the very end in the NICER data. Therefore, we broke down the full outburst into a (noisy) rising part, covering only about five days, from MJD 59737.0 to 59741.9, and a decaying part, lasting for 19 days across MJD 59741.9–59760.6. Fitting for the decaying part, a timing model including a frequency ν and frequency time derivative

ν

̇

component yielded a value of (+9.0 ± 2.1) × 10−14 Hz s−1 for

ν

̇

, which could be interpreted as a spinup under our model assumptions. We detected X-ray pulsations up to ∼95 keV in a combination of Insight-HXMT HE observations. The pulse profiles were quite stable over the whole outburst and could be well described by a truncated Fourier series using two harmonics, the fundamental and the first overtone. Both components kept alignment in the range 0.8–64 keV. The joint and time-averaged NICER and Insight-HXMT spectra in the energy range 1–150 keV were well fitted by the absorbed Comptonization model compps plus disk blackbody with two additional Gaussian components. Using the bolometric flux and spinup values both evaluated during the decay phase, we determined a magnetic field strength of (0.2–2) × 108 G for MAXI J1816−195.
The Spitzer–HETDEX Exploratory Large-Area Survey. IV. Model-based Multiwavelength Photometric Catalog
Authors: Leung Gene C. K. , Finkelstein Steven L. , Weaver John R. , Papovich Casey , Larson Rebecca L. , Chworowsky Katherine , Ciardullo Robin , Gawiser Eric , Gronwall Caryl , Jogee Shardha , Kawinwanichakij Lalitwadee , Somerville Rachel S. , Wold Isak G. B. , Yung L. Y. Aaron
Published: November 2023

We present a 0.3–4.5 μm 16-band photometric catalog for the Spitzer/HETDEX Exploratory Large-Area (SHELA) survey. SHELA covers an ∼27 deg2 field within the footprint of the Hobby–Eberly Telescope Dark Energy Experiment (HETDEX). Here we present new DECam imaging and an rizK

s
band–selected catalog of four million sources extracted using a fully model-based approach. We validate our photometry by comparing with the model-based DECam Legacy Survey. We analyze the differences between model-based and aperture photometry by comparing with the previous SHELA catalog, finding that our model-based photometry can measure point sources to fainter fluxes and better capture the full emission of resolved sources. The catalog is 80% (50%) complete at riz ∼ 24.7 (25.1) AB mag, and the optical photometry reaches a 5σ depth of ∼25.5 AB mag. We measure photometric redshifts and achieve a 1σ scatter of Δz/(1 + z) of 0.04 with available spectroscopic redshifts at 0 ≤ z ≤ 1. This large-area, multiwavelength photometric catalog, combined with spectroscopic information from HETDEX, will enable a wide range of extragalactic science investigations.
Tidal Dissipation Regimes among the Short-period Exoplanets
Authors: Louden Emma M. , Laughlin Gregory P. , Millholland Sarah C.
Published: November 2023

The efficiency of tidal dissipation provides a zeroth-order link to a planet’s physical properties. For super-Earth and sub-Neptune planets in the range R
⊕ ≲ R

p
≲ 4R
⊕, particularly efficient dissipation (i.e., low tidal quality factors) may signify terrestrial-like planets capable of maintaining rigid crustal features. Here, we explore global constraints on planetary tidal quality factors using a population of planets in multiple-planet systems whose orbital and physical properties indicate susceptibility to capture into secular spin–orbit resonances. Planets participating in secular spin–orbit resonance can maintain large axial tilts and significantly enhanced heating from obliquity tides. When obliquity tides are sufficiently strong, planets in low-order mean-motion resonances can experience resonant repulsion (period ratio increase). The observed distribution of period ratios among transiting planet pairs may thus depend nontrivially on the underlying planetary structures. We model the action of resonant repulsion and demonstrate that the observed distribution of period ratios near the 2:1 and 3:2 commensurabilities implies Q values spanning from Q ≈ 101–107 and peaking at Q ≈ 106. This range includes the expected range in which super-Earth and sub-Neptune planets dissipate (Q ≈ 103–104). This work serves as a proof of concept for a method of assessing the presence of two dissipation regimes, and we estimate the number of additional multitransiting planetary systems needed to place any bimodality in the distribution on a strong statistical footing.
Two new records of moray eels representing genera Gymnothorax and Strophidon (Actinopterygii: Anguilliformes: Muraenidae) from the Philippines
Authors: Cabebe-Barnuevo Roxanne A. , Obar El Andro A. , Penuela Dianne Frances A. , Motomura Hiroyuki , Babaran Ricardo P. , Malay Maria Celia D.
Published: November 2023

In this study, we report the collection of moray eel species Gymnothorax nudivomer (Günther, 1867) and Strophidon dorsalis (Seale, 1917) from the Western Visayas region, Philippines. Both represent new records for the country. A single specimen of G. nudivomer measuring 619 mm total length (TL) was collected from Iloilo Fish Port Complex, Iloilo and a specimen of S. dorsalis measuring 777 mm TL was collected from the fish market of Batan, Aklan. Detailed morphological descriptions and mitochondrial cytochrome oxidase I (COI) barcode sequences are provided. A comprehensive list of geographic records for both species, as well as a list of all species representing the genera Gymnothorax and Strophidon reported in the Philippines is also provided in this report.