bluuebunny/crossref_metadata_2025 huggingface dataset:
Eosinophil Peroxidase Staining Enhances the Diagnostic Utility of the Cytosponge in Eosinophilic Esophagitis
Authors: Masuda Mia Y. , Barshow Suzanne M. , Garg Shipra , Putikova Arina , LeSuer William E. , Alexander Jeffrey A. , Katzka David A. , Dellon Evan S. , Kita Hirohito , Horsley-Silva Jennifer L. , Doyle Alfred D. , Wright Benjamin L.
Published: September 2022

INTRODUCTION:

We aimed to assess the diagnostic utility of eosinophil peroxidase (EPX) staining on Cytosponge (CS) samples in eosinophilic esophagitis (EoE).

METHODS:

Esophageal biopsy (BX) samples from adult subjects with EoE were assessed using peak eosinophils per high-power field (eos/hpf), EPX, and the EoE histologic scoring system. EPX staining and eos/hpf were compared (BX vs CS).

RESULTS:

CS EPX positivity correlated with eos/hpf (CS [r = 0.82, P < 0.0001]; BX [r = 0.65, P < 0.0001]) and EoE histologic scoring system (grade [r = 0.62, P < 0.00001]; stage [r = 0.61, P < 0.0001]). CS EPX identified subjects with active EoE (area under the curve = 0.86, P < 0.0001).

DISCUSSION:

The correlation of CS EPX with eosinophilic inflammation and histologic disease severity supports its diagnostic utility in EoE.
Beta-amyloid Deposition in Biliary Atresia Reduces Liver Regeneration by Inhibiting Energy Metabolism and Mammalian Target of Rapamycin Signaling
Authors: Tian Xinbei , Wang Ying , Zhou Ying , Wu Bo , Lu Ying , Du Jun , Wang Weipeng , Cai Wei , Xiao Yongtao
Published: September 2022

INTRODUCTION:

Biliary atresia (BA) is a devastating obstructive bile duct disease found in newborns. This study aims to investigate the roles and involved mechanisms of beta-amyloid (Aβ) in the pathogenesis of BA.

METHODS:

We examined the distribution of Aβ protein and its precursor in the livers of patients with BA. A murine liver organoid and a zebrafish model were established to investigate the exact roles of Aβ in liver regeneration for BA.

RESULTS:

Both Aβ mRNA and protein significantly increased in livers of infants with BA and deposited around the central vein. In the plasma, Aβ elevated significantly in patients with BA and positively correlated with liver injury progression. In vitro, Aβ treatment induced abnormal morphology and caused impaired growth in liver organoids. Energy metabolism analysis demonstrated Aβ increased aerobic glycolysis and reduced ATP synthase in organoids, in which the mammalian target of rapamycin signaling was suppressed. In vivo, Aβ42 exposure caused liver degeneration in zebrafish larvae.

DISCUSSION:

Aβ depositing in livers of infants with BA reduced the liver regeneration through attenuating mitochondrial respiration and mammalian target of rapamycin signaling.
An Investigation on Disparity Responds of Machine Learning Algorithms to Data Normalization Method
Authors: Ahmed Haval A. , Muhammad Ali Peshawa J. , Faeq Abdulbasit K. , Abdullah Saman M.
Published: September 2022

Data normalization can be useful in eliminating the effect of inconsistent ranges in some machine learning (ML) techniques and in speeding up the optimization process in others. Many studies apply different methods of data normalization with an aim to reduce or eliminate the impact of data variance on the accuracy rate of ML-based models. However, the significance of this impact aligning with the mathematical concept of the ML algorithms still needs more investigation and tests. To identify that, this work proposes an investigation methodology involving three different ML algorithms, which are support vector machine (SVM), artificial neural network (ANN), and Euclidean-based K-nearest neighbor (E-KNN). Throughout this work, five different datasets have been utilized, and each has been taken from different application fields with different statistical properties. Although there are many data normalization methods available, this work focuses on the min-max method, because it actively eliminates the effect of inconsistent ranges of the datasets. Moreover, other factors that are challenging the process of min-max normalization, such as including or excluding outliers or the least significant feature, have also been considered in this work. The finding of this work shows that each ML technique responds differently to the min-max normalization. The performance of SVM models has been improved, while no significant improvement happened to the performance of ANN models. It is been concluded that the performance of E-KNN models may improve or degrade with the min-max normalization, and it depends on the statistical properties of the dataset.
Urgensi Pelonggaran Ketentuan Masuknya Tenaga Kerja Asing Dalam Undang-Undang No. 11 Tahun 2020 tentang Cipta Kerja
Authors: Ridho Muhammad
Published: September 2022

Berbagai ketentuan baru yang dimuat dalam Undang-Undang Cipta Kerja mengenai pengaturan masuknya tenaga kerja asing adalah tidak urgen. Sebab, meskipun secara ekonomis berpotensi menjadi katalis bagi pendapatan nasional, namun ketentuan tersebut pada nyatanya berpotensikan mengorbankankan perlindungan akan jaminan kerja buruh lokal. Padahal, perlindungan akan pekerjaan dan penghidupan yang layak bagi masyarakat merupakan salah satu amanat yang diberikan oleh Konstitusi Negara Indonesia (UUD NRI 1945).
Optimization of a Management Algorithm for an Innovative System of Automatic Switching between Two Photovoltaic and Wind Turbine Modes for an Ecological Production of Green Energy
Authors: Lahlou Yahya , Hajji Abdelghani , Aggour Mohammed
Published: September 2022

Today, renewable energy and energy efficiency are key to limiting global warming and preventing the dangerous effects of climate change. The biggest problem with conventional solar and wind turbine systems is the intermittency of electrical power generation. Even if these two energy sources can be complementary, the space occupied by these hybrid systems remains very important. This work proposes an improved management algorithm for a patented transformable photovoltaic-wind system, which mainly uses two flexible photovoltaic panels which are automatically deformed by an electromechanical system from the planar shape to the semi-cylindrical shape of the Savonius wind turbine blades. When weather conditions change, this system switches to eco-friendly photovoltaic (PV) or wind turbine (WT) mode, allowing a good total power generation from two solar power sources or wind turbine power. The contribution brought for this work relates to the realization and the improvement of the management algorithm to determine a better change to the mode PV or the mode WT. The operation test was simulated in 8760 hours for the year 2021. This developed algorithm allows several theoretical calculations of the power produced from solar radiation and wind speed data, thereafter the algorithm compare and determines the overall power and selects the optimal PV or WT mode. In this study, the overall power generated by the invented system produces more electricity per hour, the power Pt increases by 75.55% compared to the power Pwt, and also the power Pt increases by 68.15% compared to Pvp power.
Models of conversion in Modern English
Authors: Rubanets Tetyana , Kiyko Svitlana , Kiyko Yuriy
Published: September 2022

The article under studies deals with the issue of the conversives structure and semantic characteristics in the models noun – verb, verb – noun, noun – adjective and adjective – noun. It consists of four stages. The first stage regards the main approaches to the phenomenon of conversion in line with system-structural, communicative-functional and cognitive paradigms, as well as elaborates the definitions, used in the work. The purpose of the second stage is to form the research material. By a continuous sample of three academic dictionaries New Webster’s Dictionary of the English Language (2009. 5th ed. London: Pearson education), Macmillian English Dictionary (2006. In M. Rundell (ed.), For advanced learners. London: Palgrave Macmillan) and Longman Dictionary of Contemporary English (2009. 5th ed. London: Pearson education), a total amount of 18,263 conversives was written out. To avoid repeating the conversives given in the dictionaries, we have developed a sample, in which every conversion pair occurred once. The total number of the studied conversives is 10,140 tokens, grouped into 5,070 conversion pairs. The third stage highlights the structural and semantic features of conversives in modern English. It describes the peculiarities of parts of speech and semantic transitions, as well as determines the conversives structural models and their modifications. In order to establish regular semantic changes, the conversion semantic models are singled out, quantitative characteristics of each model are established and the most productive transitions from the generative to the derivative are described. At the final stage, the results of the work are summarized and the prospects for further research are outlined. The obtained results will enrich the theory of nomination with the new systematized material of conversives, which are an integral part of natural languages, and the analysis of English language conversives will supplement the theoretical and methodological basis for further study of the phenomenon of conversion in other languages.
Evaluation of Septoria leaf spot (Septoria helianthi) alone and in combination with other foliar fungal spots on sunflower
Authors: Levitskaya Kristina M. , Soroka Anatoliy I. , Lyakh Viktor A.
Published: September 2022

In recent years, Septoria leaf spot has taken a strong place in the list of economically important diseases of sunflower. It may be a favorable factor for the development of other diseases on sunflower plants too. The aim of the research was to evaluate the frequency and degree of infection of sunflower plants with Septoria helianthi as well as possibility of simultaneous infection with this pathogen and other fungi which cause foliar spots, such as downy mildew, Alternaria leaf spot and Phoma black stem under conditions of stationary infectious nursery. The year 2021 turned out to be extremely favorable for the development of fungal leaf spots on sunflower. Assessment of fungal diseases of sunflower plants was performed in F2 families obtained after crossing ZL22A, ZL58A, ZL70A, ZL78A, and ZL169A lines of Zaporozhye breeding (Ukraine) with HAR7 line (originating from the USA). Each F2 family (sample) was obtained from self-pollination of one F1 plant with varying severity of Septoria disease. It was found that in the conditions of 2021, sunflower was quite affected by Septoria disease. The percentage of injured plants in F2 samples ranged from 41.0 to 100.0%. The severity of disease was different. Less resistant genotypes included plants with lesions on sunflower leaves of lower, middle, and upper tiers in approximately equal numbers, while more resistant genotypes had almost no plants with injured leaves of upper tiers. It was established that the development of Phoma disease occurred both on plants with Septoria leaf spot and on healthy plants. On average, among the plants infected with Phoma macdonaldii, the proportion of plants jointly affected by Phoma and Septoria diseases was 2/3. However, the frequency of simultaneous infection of plants with S. helianthi and P. macdonaldii in genotypes with different resistance to Septoria leaf spot differed significantly and ranged from 80% in less resistant to 40% in more resistant accessions. Most plants (about 90%) infected with Plasmopara halstedii were simultaneously infected with S. helianthi. That is, both of these pathogens can simultaneously develop on the same plant and lead to a decline in its basic physiological functions. The rate of simultaneous damage of sunflower by Alternaria and Septoria was quite low compared to plant damage by Alternaria alone and was less than 30%. This may mean that the pathogen of Alternaria leaf spot avoids plants with existing S. helianthi fungus.
Normal or elevated prolactin is a good indicator to show pituitary stalk interruption syndrome in patients with multiple pituitary hormone deficiency
Authors: Eren Erdal , Ongen Yasemin Denkboy , Ozgur Taner , Ozpar Rifat , Demirbas Ozgecan , Yazici Zeynep , Tarim Omer
Published: September 2022

Objectives

To determine the importance of serum prolactin (PRL) in the detection of pituitary stalk interruption syndrome (PSIS) in children with multiple pituitary hormone deficiency (MPHD). We hypothesized that PRL elevation might be a diagnostic indicator of pituitary stalk pathologies.

Methods

Clinical, radiological, and laboratory features of the 50 cases of MPHD were studied.

Results

The median age at presentation of the 50 cases (52%, n=26 were female) was 6.61 (0.02–18.9) years. PSIS was detected in 60% (n=30), pituitary hypoplasia in 32% (n=16), partial empty sella in 6% (n=3), and only 2% (n=1) was reported as normal. Out of 50 patients, 21.3% (n=10) were hypoprolactinemic, 44.7% (n=19) were normoprolactinemic, and 34% (n=16) were hyperprolactinemic. The median PRL value was 27.85 (4.21–130) ng/mL in patients with PSIS and 5.57 (0–41.8) ng/mL in patients without PSIS. Additional hormone deficiencies, especially ACTH and LH were detected in follow-up.

Conclusions

Patients with normal or high prolactin levels deserve special attention regarding the possibility of PSIS. Furthermore, we emphasize the importance of regular follow-up and monitoring for multiple pituitary hormone deficiencies in all patients with a single pituitary hormone deficiency.
Equivalence and (un)translatability: Instances of the transfer between Romanian and English
Authors: Cozma Mihaela
Published: September 2022

In very broad terms, translatability means that the translator is able to establish a relation of equivalence between a certain source text and its target variant. The notion of equivalence has a very complicated status in translation studies, because, on the one hand, this discipline does not provide a generally accepted definition of the concept, and, on the other, because it has a very complex nature, involving a variety of levels. The present article is based on the assumption that, even if there are situations when the source-language lexico-semantic items, grammatical structures or whole texts are so problematic that they seem almost impossible to be transferred into another language. The term “untranslatability” is not appropriately used with reference to such situations, because a certain type of equivalence can be always achieved. The article will approach the notions of equivalence and (un)translatability in both theoretical and practical terms, offering relevant examples specific to the transfer between Romanian and English.
Accurate determination of tetravalent uranium reduced by microorganisms via a potentiometric titration procedure
Authors: Chen Shunzhang , Cheng Yanxia , Zeng Qian , Zhu Ting , Li Feize , Lan Tu , Yang Yuanyou , Yang Jijun , Liao Jiali , Liu Ning
Published: September 2022

Although bioreduction induced by microorganisms has been considered to play an important role in the chemical and migration behaviors of uranium in nature, the accurate determination of tetravalent uranium reduced by microorganisms is still difficult to achieve. In this work, potentiometric titration via K2Cr2O7 was used to quantitatively determine the microorganism reduced tetravalent uranium (U(IV)) for the first time. By evaluating the influence of microorganism substance content on the titration of U(IV), the appropriate determination range of U(IV) and biomass was confirmed, and U(IV) induced by bioreduction in three microorganisms was determined. With this method, U(IV) of more than 0.12 mg in microorganisms can be quantitatively measured with an accuracy of 2.2% and a precision of 1.3%, which has been established with the premise that the pretreatment biomass and quantity of U(IV) are in an appropriate range. Compared with the estimated values via the changes in hexavalent uranium (U(VI)) concentration in the bioreduction system, the results obtained by this method can more accurately reflect the quantity of U(IV) in microorganisms. This work can help us to better understand the bioreduction behavior of uranium in the environment.
Entrevista com Maria da Conceição Lopes
Authors: Pastre Máximo Bruno , Oliveira Calazans Marília , Sarrò Ramon
Published: September 2022

Este texto é uma entrevista com a pesquisadora Maria da Conceição Lopes (Faculdade de Letras da Universidade de Coimbra) sobre o seu envolvimento no projeto “Mbanza Kongo: lugar a desenterrar para preservar” do governo de Angola e da UNESCO. Sua participação consistiu na coordenação de prospecções e escavações arqueológicas no centro histórico de Mbanza Kongo, resultando em diversos artigos, e na fundamentação empírica que culminou na nomeação da cidade como patrimônio cultural da humanidade. Conceição Lopes discute como ocorreu seu envolvimento e o processo de trabalhar em uma cidade histórica tão relevante para as dinâmicas históricas do colonialismo entre os séculos XVI e XIX.
Narrativas del paisaje histórico afroecuatoriano en La Concepción (Carchi-Ecuador)
Authors: Balanzategui Daniela
Published: September 2022

Resumen: Este artículo explora el pasado afroecuatoriano, a partir del desencuentro con la historia oficial y el encuentro con el paisaje histórico diaspórico, esos “otros paisajes”, en la comunidad de La Concepción, ubicada en el “Territorio Ancestral Afroecuatoriano del Valle del Chota-Mira” (Carchi-Ecuador). La construcción de una historia blanco-mestiza ecuatoriana integra el pasado, patrimonio y cultura material afroecuatoriana mientras se mantenga su condición colonial de pasado esclavo, explotado y negro. Sin embargo, esos otros paisajes históricos están dinamizados de forma particular a partir del manejo de la cultura material preservada, destruida, abandonada, patrimonializada y revitalizada en la Concepción. En estos otros paisajes, los afroecuatorianos utilizan de forma consciente e inconsciente el discurso histórico oficial y las prácticas de protección patrimonial. Este proceso es posible en un paisaje diaspórico, cimarrón, rizomático, cambiante e interminable, en términos de Glissant. 
 
Abstract: This article explores the Afro-Ecuadorian past, from the perspective of the point of discord with official history and the encounter with the diasporic historical landscape, “other landscapes” in the community of La Concepción in the “Ancestral Afro-Ecuadorian Territory of the Valley of the Chota-Mira” (Carchi-Ecuador).  The construction of a white-mestizo history of Ecuador integrates the Afro-Ecuadorian past into it, along with the material heritage and culture, while maintaining its colonial condition of slave, exploited and black past.  Nevertheless, these other historic landscapes are particularly invigorated by the management of material, preserved, destroyed, abandoned, heritage status, and revitalized culture in La Concepción. In these other landscapes, Afro-Ecuadorians consciously and unconsciously make use of the official historical discourse and the practices of heritage protection. This process is possible in a diasporic, maroon, rhizomatic, changing and unending landscape, in Glissant’s terms.
CONSUMERS’ PERCEPTIONS OF HEALTH AND FACTORS INFLUENCING FULFILMENT OF THE NEED FOR HEALTHCARE IN EU COUNTRIES
Authors: Antošová Irena , Hazuchová Naďa , Stávková Jana
Published: September 2022

The paper deals with subjective perceptions of health by individuals. The research aimed at understanding socioeconomic and demographic factors influencing the fulfilment of healthcare needs and at finding out categories of factors that lead to the highest chances of meeting the need in consumer segments formed according to perceptions of their health status. The analyses were based on the EU-SILC database of primary data on the income situation and living conditions of households. In 2017, the database included extra questions on health. The method of cluster analysis was employed. As a result, three clusters of individuals representing EU countries formed depending on the perceived state of health – the authors named the clusters ‘optimistic’, ‘neutral’, and ‘pessimistic’. For each segment, the binary logistic regression was applied to determine categories of factors leading to the highest probability of meeting the healthcare need. The greatest influence over the fulfilment of the need for healthcare has been confirmed for the factor “Sector of economic activity”, followed by the type of economic activity. Some differences were revealed between segments. For example in the third segment, i.e., respondents who rated worst their health, a strong influence of education has been identified. The highest chances of meeting the need for health care are achieved in the first segment by executives, but in the second and the third segment by individuals active in education. On the other hand, craftsmen and workers have the lowest chances. In all segments, the influence of household composition was confirmed, with single households and single-parent households reporting lower chances of meeting their healthcare needs. Respondents who did not feel their healthcare need was met mostly said it was due to financial reasons, long waiting times, or fear of medical treatment.
Denosumab increases spine bone density in women with anorexia nervosa: a randomized clinical trial
Authors: Haines Melanie S , Kimball Allison , Meenaghan Erinne , Santoso Kate , Colling Caitlin , Singhal Vibha , Ebrahimi Seda , Gleysteen Suzanne , Schneider Marcie , Ciotti Lori , Belfer Perry , Eddy Kamryn T , Misra Madhusmita , Miller Karen K
Published: September 2022

Objective

Anorexia nervosa is complicated by high bone resorption, low bone mineral density (BMD), and increased fracture risk. We investigated whether off-label antiresorptive therapy with denosumab increases BMD in women with anorexia nervosa.

Design

Twelve-month, randomized, double-blind, placebo-controlled study.

Methods

Thirty ambulatory women with anorexia nervosa and areal BMD (aBMD) T-score <−1.0 at ≥1 sites were randomized to 12 months of denosumab (60 mg subcutaneously q6 months)(n = 20) or placebo (n = 10). Primary end point was postero-anterior (PA) lumbar spine aBMD by dual-energy x-ray absorptiometry. Secondary end points included femoral neck aBMD, tibia and radius volumetric BMD and bone microarchitecture by high-resolution peripheral quantitative CT, tibia and radius failure load by finite element analysis (FEA), and markers of bone turnover.

Results

Baseline mean (±s.d.) age (29 ± 8 (denosumab) vs 29 ± 7 years (placebo)), BMI (19.0 ± 1.7 vs 18.0 ± 2.0 kg/m2), and aBMD (PA spine Z-score −1.6±1.1 vs −1.7±1.4) were similar between groups. PA lumbar spine aBMD increased in the denosumab vs placebo group over 12 months (P = 0.009). The mean (95% CI) increase in PA lumbar spine aBMD was 5.5 (3.8–7.2)% in the denosumab group and 2.2 (−0.3–4.7)% in the placebo group. The change in femoral neck aBMD was similar between groups. Radial trabecular number increased, radial trabecular separation decreased, and tibial cortical porosity decreased in the denosumab vs placebo group (P ≤ 0.006). Serum C-terminal telopeptide of type I collagen and procollagen type I N-terminal propeptide decreased in the denosumab vs placebo group (P < 0.0001). Denosumab was well tolerated.

Conclusions

Twelve months of antiresorptive therapy with denosumab reduced bone turnover and increased spine aBMD, the skeletal site most severely affected in women with anorexia nervosa.
Effect of novel DOPO-g-coupling agent treated wood fibers on properties of composite phenolic foams
Authors: Ma Yufeng , Geng Xiang , Zhang Xi
Published: September 2022

9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) graft γ-amino propyltriethoxy silane (APS), γ-glycidoxy propyltrimethoxy silane (GPS), and methacryloyl propyltrimethoxysilane (MPS) were synthesized and introduced on the surface of wood fiber. DOPO-g-APS (GPS and MPS) treated wood fibers (DAWF, DGWF, and DMWF) were used to prepare composite phenolic foams (DAWFCPF, DGWFCPF, and DMWFCPF). The chemical structures of DOPO-g-APS (GPS and MPS) were confirmed by Fourier transform infrared (FT-IR) spectra and nuclear magnetic resonance. The structures of DAWF, DGWF, and DMWF were confirmed by FT-IR. The diffraction peak positions were basically unchanged, but the crystallinity was slightly increased. Compared with WF, thermal stabilities were increased. The residue (800 °C) was slightly reduced. Compared with phenolic foam, the properties of DAWFCPF and DGWFCPF were better than others. Besides compression strength, the mechanical properties were increased dramatically, limited oxygen index was slightly enhanced, the cellular pore distribution was more regular, and the size of bubble cell was smaller and more uniform. By comprehensive analysis, the properties of DAWFCPF were best in all samples. The interfacial compatibility was significantly improved between DAWF and phenolic resin. These results confirmed that DOPO-g-APS is a suitable material for treating wood fibers and preparing composite phenolic foams.
Predicting color change in wood during heat treatment using an artificial neural network model
Authors: Nguyen Thi Hai Van , Nguyen Tat Thang , Ji Xiaodi , Guo Minghui
Published: September 2022

Understanding and mastering the color change of wood during heat treatment is essential in the wood working industry because it saves time and reduces energy costs. An artificial neural network (ANN) was employed in this study to establish the relationship between the process parameters of heat treatment and the color change of wood. Three important parameters: temperature (180 °C, 190 °C, 200 °C, 210 °C, and 220 °C), treatment time (2 h, 4 h, 6 h, and 8 h), and wood species (larch and poplar) were considered as inputs to the neural network. There were four neurons in the hidden layer that were used, and an output layer as wood color. According to the results, the mean absolute percentage errors were determined as 0.53%, 0.65%, and 0.31% in the prediction of color change color (ΔE) values for training, validation, and testing data sets, respectively. Determination coefficients (R2) greater than 0.99 were obtained for all data sets with the proposed ANN models. These results showed that ANN models can be used successfully for predicting the color changes in wood during heat treatment.
Surface modification of tire rubber waste by air plasma for application in wood-cement panels
Authors: Vilela Alan Pereira , Silva Danillo Wisky , Mendes Lourival Marin , Martins Maria Alice , Brandão Vaz Lívia Elisabeth Vasconcellos , Mendes Rafael Farinassi
Published: September 2022

Much research has been carried out to improve the wettability and to overcome the low adhesion of tire rubber for use in developing new building materials, such as wood-cement panels. Corona surface treatment (air plasma) of rubber particles was used in this study with various application times to improve adhesion and the interface between the particles and the cementitious matrix. Another aspect evaluated in this study was the partial replacement of wood particles by tire rubber waste in wood-cement panels. The particulate rubber residue was subjected to various corona application times to determine the most suitable treatment; the samples showed the most desirable qualities after 20 min of air plasma treatment. Then, panels were produced using Pinus oocarpa particles associated with various contents of tire rubber after corona treatment. Overall, after 20 min of air plasma treatment, the wettability and adhesion properties of tire rubber waste improved. The use of 5% rubber to replace pine wood in wood-cement panels led to a substantial improvement in the physical-mechanical properties evaluated, making its production feasible and promoting the reuse of a material harmful to the environment.
Contenção e Liberação nas políticas de Educação Infantil e Ensino Fundamental
Authors: Guerra Dhyovana , Figueiredo Ireni Marilene Zago
Published: September 2022

Este artigo examina como as Políticas de Educação Infantil e do Ensino Fundamental (2006-2016), no Brasil, incorporam, dissimulam ou se contrapõem aos processos de Contenção e de Liberação. Nesse sentido, a pesquisa bibliográfica e documental, de abordagem qualitativa, retoma, a partir dos conceitos de Contenção e de Liberação, as expectativas geradas pelas necessidades político-ideológicas e socioeconômicas de reprodução do sistema capitalista, as quais correspondem aos mecanismos de controle do Estado em relação ao acesso à escola, por parte de diferentes classes ou frações de classe para formação da força de trabalho. Identifica-se que o atual sistema econômico, social, político e ideológico funciona como indutor dos processos de Contenção de demandas por educação escolar.
Palavras-chave: Política Educacional; Educação Infantil; Ensino Fundamental; Política de Contenção e Liberação.
Simultaneously measure the concentrations of busulfan and phenytoin in human plasma using an HPLC-MS/MS method: Application to the TDM for children underwent hematological stem cell transplantation
Authors: Sun Ning , Li Zhuo , Zhang Meng , He Huan , Zhao Libo , Mei Dong , Zhu Guanghua , Wang Xiaoling
Published: September 2022

In this work, a simple and rapid high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method was developed and validated to carry out the simultaneous measurement of busulfan (BU) and phenytoin (PHT) in the plasma of children. In this method, plasma sample could be prepared by one-step protein precipitation using 1 mL of methanol/water (1:1, v/v). After centrifugation (14,500 rpm, 5 min, 4 °C), 10 μL of the supernatant was injected into a Hypersil Gold C18 column (150 × 2.1 mm, 5 μm, Thermo Fisher Scientific) for separation by gradient elution. Quantification was carried out using multiple reactions monitoring (MRM) under positive scan mode. In the method verification, the calibration curves of BU and PHT showed satisfactory linearity (r > 0.99) at the concentration ranging from 0.02 to 20 μg mL−1. The accuracy and precision were tested at four concentration levels (including the LLOQ level) with the relative error (RE) ranging from −0.80% to 11.45% and coefficient of variation (CV) between 0.93% and 7.74%. There was no pronounced matrix effect to interfere with the quantitative analysis. Compared to determine BU and PHT using two individual methods, less pre-treatment process, labor and blood sample volume are required in this proposed method. Finally, this method was successfully applied to the therapeutic drug monitoring of BU and PHT for children underwent hematological stem cell transplantation.
MISINTERPRETATION OF SALAFI JIHADIST ON JIHĀD VERSES: AN ANALYSIS
Authors: Qotadah Hudzaifah Achmad , Syarifah Maisyatusy , Achmad Adang Darmawan
Published: September 2022

Nowadays, the term "Jiha̅d" has taken on the connotation of a frightening term (logophobia). This is due to the fact that religious extremists use it in a very narrow context. Unfortunately, the concept of pure and vast Jihad has been tainted by insights and actions that have transcended its borders, resulting in the term Jihad being viewed negatively by some segments of the world's society. The study examines how these scholars (of Salafi Jihadism) interpret these specific verses of the Holy Quran, as well as how their concepts and explanations regarding Jihad verses differ from other scholars. A thorough qualitative method is used in this article to examine the misinterpretation of the Jiha̅d verses used by Salafi Jihadism. The study shows, first, the Salafi-Jihadi movement interprets jihad verses only based on literal meanings, ignoring the context of the asbab nuzul verses, pay less attention to the period and socio-historical verses revealed. Second, considering jihad as a physical struggle only and war in the way of Allah as a natural obligation for Muslims.
PENEMUAN HUKUM CERAI GUGAT OLEH HAKIM PADA PENGADILAN AGAMA BERDASAR PARADIGMA POST-POSITIVISME
Authors: Helmi Muhammad
Published: September 2022

This study aims to guide judges to the Religious Courts in realizing substantive justice about divorce decisions. Based on the Presidential Instruction on the Compilation of Islamic Law and the books of fiqh, if the wife filed for divorce, then she did not get a living from the ex-husband. However, there is a rule of a Supreme Court Circular, the rule is a wife filed for divorce, but she got a living from her ex-husband except for nusyus. The method is normative juridical with a paradigmatic study of Guba and Lincoln. In the ontology of the postpositivism paradigm, the judge views reality as imperfect rules. Therefore, the judge is obliged to explore the laws that live in the community. Epistemology is a rule that has limitations so that it adapts to situations and conditions, but judges must remain objective. The methodology goes from verification to falsification. Because the judge needs to criticize and falsify the injustice that occurs at trial for the wives, for example, the husband of a civil servant feels that he is difficult by the rules, so he orders his wife to sue for divorce which results in not getting a living from her ex-husband
Heat Conductance Oscillations in Two Weakly Connected Charge Kondo Circuits
Authors: Nguyen Thanh Thi Kim , Kiselev Mikhail
Published: September 2022

We revisit a model describing Seebeck effect on a weak link between two charge Kondo circuits, which has been proposed in the [Phys. Rev. B 97 (2018) 085403]. We calculate the thermoelectric coefficients in the perturbation theory assuming smallness of the reflection amplitudes of the quantum point contacts. We focus on the linear response equations for the heat conductance in three different scenarios as: Fermi liquid vs Fermi liquid, Fermi liquid vs non-Fermi liquid, non-Fermi liquid vs non-Fermi liquid. The oscillations of the heat conductance as a function of the gate voltage of each quantum dot are analysed in both Fermi liquid and non-Fermi liquid regimes. We discuss possible experimental realizations of the model to observe the signatures of the non-Fermi liquid behaviour in the heat conductance measurements.
USO DA BIBLIOTECA E INTERNET NO ESTUDO AUTODIRIGIDO DE UNIVERSITÁRIOS EM DIFERENTES METODOLOGIAS DE ENSINO
Authors: Guedes-Granzotti Raphaela Barroso , Cardoso Gabriela Pimentel Figueira , Santos Wictor Aleksandr Santana , Barreto Tâmara Isis Santana Santos , Santos Ronaide Paula dos , Silva Kelly da
Published: September 2022

Objetivo: Verificar uso da biblioteca e da internet para o estudo autodirigido de estudantes de Fonoaudiologia e sua relação com as estratégias de estudo e aprendizagem em diferentes metodologias de ensino. Material e Método: A pesquisa foi aprovada pelo Comitê de Ética em Pesquisa. Participaram 200 discentes, sendo 100 de um curso de Fonoaudiologia que utiliza a Metodologia Ativa (GMA) e 100 que utiliza a Metodologia Tradicional de Ensino (GMT). Foi aplicada a versão em português do inventário Learning And Study Strategies Inventory (LASSI) cujas perguntas abordam a respeito da frequência de acesso à biblioteca e à internet, além de questões voltadas às estratégias de ensino e aprendizagem. Os resultados foram analisados no SPSS 20.0 por meio dos testes Mann-Whitney e Spearman, sendo estipulado o nível de significância de 5%. Conclusões: Discentes do GMA frequentaram mais a biblioteca do que discentes do GMT. Houve correlação positiva entre frequência de acesso à biblioteca com as subescalas de processamento de informação, organização de tempo, atitude e auxiliar de estudos para o GMT e uma correlação negativa entre frequência de acesso à Internet e processamento de informação para o GMA. Na correlação das subescalas o processamento de informação foi estatisticamente diferente entre os dois grupos da amostra, nesta direção, a criação de práticas voltadas para o uso da biblioteca e internet em paralelo as estratégias de aprendizado que auxiliem a formação dos estudantes de Fonoaudiologia são vistas como essencial.
sEMG-Based Upper Limb Movement Classifier: Current Scenario and Upcoming Challenges
Authors: Cagliari Tosin Maurício , Machado Juliano Costa , Balbinot Alexandre
Published: September 2022

Despite achieving accuracies higher than 90% on recognizing upper-limb movements through sEMG (surface Electromyography) signal with the state of art classifiers in the laboratory environment, there are still issues to be addressed for a myo-controlled prosthesis achieve similar performance in real environment conditions. Thereby, the main goal of this review is to expose the latest researches in terms of strategies in each block of the system, giving a global view of the current state of academic research. A systematic review was conducted, and the retrieved papers were organized according to the system step related to the proposed method. Then, for each stage of the upper limb motion recognition system, the works were described and compared in terms of strategy, methodology and issue addressed. An additional section was destined for the description of works related to signal contamination that is often neglected in reviews focused on sEMG based motion classifiers. Therefore, this section is the main contribution of this paper. Deep learning methods are a current trend for classification stage, providing strategies based on time-series and transfer learning to address the issues related to limb position, temporal/inter-subject variation, and electrode displacement. Despite the promising strategies presented for contaminant detection, identification, and removal, there are still some factors to be considered, such as the occurrence of simultaneous contaminants. This review exposes the current scenario of the movement classification system, providing valuable information for new researchers and guiding future works towards myo-controlled devices.
Училища Министерства государственных имуществ в системе народного просвещения
Authors: Kalinina Elena
Published: September 2022

Образовательные реформы первой половины XIX в. предполагали формирование новой системы народного просвещения в России. Важной составляющей реформ явилось создание сельских школ различного ведомственного подчинения. В статье на основе архивных источников, материалов периодической печати, воспоминаний штатных смотрителей училищ, бывших учащихся рассматривается становление и развитие училищ Министерства государственных имуществ в селениях государственных крестьян. Школы этого ведомства были самыми многочисленными и добились наиболее четкой организации учебного процесса и хозяйственной деятельности.
Размышления о целях и результатах
Authors: Lebedev Oleg
Published: September 2022

Лебедев Олег Ермолаевич — доктор педагогических наук, член-корреспондент РАН, профессор Московской высшей школы социальных и экономических наук. Эл. адрес: o_lebed@mail.ru Адрес: Московская высшая школа социальных и экономических наук, Россия, 119571, Москва, пр. Вернадского, д. 82, корп. 2.С позиции и в контексте шестидесятилетнего опыта педагогической деятельности автора рассматривается проблема взаимосвязи целей и результатов в сфере образования. Общие цели школьного образования представлены как трехуровневая система: развитие способности выбирать образ жизни, адекватный современным тенденциям изменения общества; формирование опыта самостоятельного решения познавательных, коммуникативных и иных значимых для учащихся проблем; освоение способов деятельности, применимых в школьной практике и за ее пределами.Обсуждаются проблемы интерпретации социального заказа системе образования. Современный социальный заказ школе, отражающий потребности быстро меняющегося общества, определяется как освоение выпускниками нового образа жизни, который предполагает решение задачи выбора в ситуации неопределенности. Отмечается существующий в настоящее время разрыв между необходимостью обеспечить соответствие целей школьного образования социальному заказу и сохранением традиционных целевых ориентиров на достижение суммы результатов по учебным дисциплинам. Подчеркивается, что формирование полных, глубоких и прочных знаний не является главной целью школьного образования: учебные программы по школьным предметам следует рассматривать как набор возможностей, которые ученик может использовать в той степени, которая соответствует его познавательным способностям и запросам. Указывается на необходимость модернизации основных элементов предметно-классно-урочной системы.Смысл современного школьного образования определяется как воспитание интеллигентного человека, способного принимать ответственные решения в ситуации выбора в различных сферах жизни.
Reading out of Love. Review of the book: Abelyuk Y. Praktika chteniya: uchebnometodicheskoe posobie [The Practice of Reading: Study Guide]
Authors: Arkhangelsky Alexander
Published: September 2022

The book represents a collection of articles written at different times, all devoted to the development of school students’ reading competencies in today’s world. The author is convinced that diverse approaches should be used to engage high school students in reading, depending on the student’s interests and personal characteristics. There is no (and there cannot be any) oneandonly methodology or any single dominant educational model in this everchanging world.
Foreword to the Russian Edition of K. Kennedi’s, M. Peters, M. Thomas "How to Use Value-Added Analysis to Improve Student Learning"
Authors: Lubimov Lev
Published: September 2022

Foreword to the Russian Edition of K. Kennedi’s, M. Peters, M. Thomas "How to Use Value-Added Analysis to Improve Student Learning".
Corpus Analysis of the Subject’s Epistemic Position in English Dialogical Discourse
Authors:   Taras Shevchenko National University of Kyiv, Shubko Viktoriia
Published: September 2022

The given article is devoted to highlighting the functions of the epistemic verb to know as a marker of the self-position of the subject in the artistic dialogic discourse on the material of the works by D.H. Lawrence. The epistemic self-position reflects the subject’s knowledge of the world, his worldview, his points of view and his beliefs. It refers to the speaker’s knowledge of the subject of speech, the degree of confidence in expression. Modern corpus-oriented studies of discourse are performed in three directions, namely, textual (study of the choice of language units, meanings and models in texts); critical (combination of critical discourse analysis and system functional linguistics); contextual (taking into account situational factors of communication, involvement of the theory of speech acts and pragmatics). Due to the explanatory inflexibility of the existing electronic corpora of the English language, that is the impossibility of a complete analysis of the presented contexts, our own corpus of texts was created to study the epistemic position of a subject in English dialogic discourse. It has been illustrated by the example of the works by David Herbert Lawrence, one of the key English writers of the early twentieth century. We have singled out and framed the contexts of the use of epistemic verbs (such as, know, think, seem, believe, understand, suppose, guess, expect, hope). The selected contexts of the use of epistemic verbs in artistic dialogic discourse will be analyzed in semantic and pragmatic aspects, namely – the meaning of the studied epistemic markers, such as reliability, faith, confidence, etc., and their pragmatic usage to express strategies and tactics of I-concept. The perspective of this study is a detailed analysis of the semantic and pragmatic features of epistemic markers in artistic discourse.
Роль ООН в защите прав жертв преступлений
Authors: Есаян Армен Карленович
Published: September 2022

В статье отмечается, что за последние годы рост законодательства о правах жертв, расширение программ помощи жертвам, углубление и распространение ориентированного на жертвы образования и профессиональной подготовки, а также совершенствование виктимологических исследований создали динамичную синергию, которая изменила отношение к жертвам в значительной части стран, сплотившись вокруг принципов Декларации ООН об основных принципах правосудия для жертв преступлений и злоупотребления властью.
Pemanfaatan Buah Bakau Rhizophora sp. dan Sonneratia sp. sebagai Bahan Baku Kopi Analog
Authors: Nusaibah Nusaibah , Putri Cahya Mirawati , Pangestika Widya , Luthfiyana Novi
Published: September 2022

Bakau merupakan tanaman yang banyak ditemukan di pesisir Indonesia, namun demikian belum banyak dimanfaatkan sebagai produk konsumsi, padahal bakau memiliki kandungan nutrisi dan antioksidan yang cukup tinggi. Pengembangan produk dari bahan baku buah bakau perlu dilakukan, salah satunya kopi analog dari buah bakau Rhizophora sp. dan Sonneratia sp. Tujuan penelitian ini adalah untuk menentukan kandungan proksimat, antioksidan, tingkat kesukaan konsumen melalui uji hedonik dari masing-masing produksi kopi analog. Penelitian ini menggunakan tiga perlakuan bahan baku yang berbeda yaitu kopi bubuk komersial murni jenis arabika (K0) sebagai kontrol, kopi analog dari buah bakau Rhizophora sp. (K1), dan Sonneratia sp. (K2). Hasil penelitian menunjukkan bahwa persentase kadar air berkisar antara 3,33-7,31% dan kadar abu berkisar antara 2,57-3,16%, dari dua parameter tersebut, kedua sampel (K1 dan K2) telah memenuhi standar SNI Kopi 01-3542-2004. Sedangkan persentase kadar lemak berkisar antara 9,06-12,6% dan kadar protein 7,09-11,59% dari dua parameter tersebut nilai tertinggi diraih oleh perlakuan K3. Berdasarkan pengujian aktivitas antioksidan dalam satuan % inhibisi diperoleh hasil persentase antara 61,63-77,15% dengan nilai tertinggi diraih oleh K2. Berdasarkan uji hedonik diperoleh tingkat kesukaan warna (netral-suka), aroma (suka), rasa (suka), tekstur (suka). Perbedaan jenis bahan baku yang digunakan memberi pengaruh nyata pada aroma dan warna, sedangkan pada rasa dan tekstur tidak berpengaruh pada tingkat kesukaan.
Efektivitas Penambahan Serbuk Daun Mangrove (Sonneratia caseolaris) terhadap Kualitas dan Umur Simpan Roti Tawar
Authors: Sumartini Sumartini , Harahap Kurnia Sada , Luthfiyana Novi
Published: September 2022

Roti tawar merupakan pilihan praktis masyarakat untuk sarapan sebagai alternatif pengganti nasi. Permasalahan terbesar pada roti tawar salah satunya, yaitu mudah mengalami penurunan mutu dikarenakan umur simpan yang pendek sehingga sangat cepat ditumbuhi jamur dan munculnya bau tengik. Upaya yang dapat dilakukan untuk memperpanjang umur simpan dan kualitas roti tawar adalah penambahan antioksidan alami berupa serbuk daun mangrove (Sonneratia caseolarils). Tujuan penelitian ini menentukan pengaruh penambahan serbuk daun mangrove (SDM) terhadap kualitas dan umur simpan roti tawar. Metode penelitian ini mengikuti Rancangan Acak Lengkap (RAL) yang terdiri dari enam perlakuan yaitu penambahan SDM 0g/100g (kontrol), 0,5g/100g, 1g/100g, 1,5g/100g, 2g/100g, dan 2,5g/100g dengan tiga kali ulangan. Data dianalisis dengan ANOVA dilanjutkan uji Jarak Nyata Terdekat Duncan (JNTD) pada taraf 0,05. Hasil penelitian menunjukkan bahwa penambahan SDM secara signifikan meningkatkan Perlakuan SDM 0,5-1,50 g/100g tidak berpengaruh secara signifikan pada volume dan kekerasan roti tawar namun perlakuan SDM 2-2,5g/100g berpengaruh secara signifikan pada volume dan tekstur roti tawar. Penambahan SDM pada roti tawar dapat meningkatkan persen inhibisi antioksidan pada roti tawar. Perlakuan penambahan SDM terbukti efektif dalam mengurangi tingkat akumulasi peroksida dengan perlakuan terbaik pada penambahan SDM 2g/100g yang dapat mengurangi tingkat akumulasi peroksida selama delapan hari masa simpan.  Hal ini dikarenakan penambahan serbuk daun mangrove berpotensi menurunkan laju oksidasi lemak dan meningkatkan peran antioksidan selama masa sinpan roti tawar.