bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of a Standardized Nursing Process Using NANDA International, Nursing Interventions Classification and Nursing Outcome Classification Terminologies: A Systematic Review
Authors: Rodríguez-Suárez Claudio-Alberto , González-de la Torre Héctor , Hernández-De Luis María-Naira , Fernández-Gutiérrez Domingo-Ángel , Martínez-Alberto Carlos-Enrique , Brito-Brito Pedro-Ruymán
Published: September 2023

The decision-making in clinical nursing, regarding diagnoses, interventions and outcomes, can be assessed using standardized language systems such as NANDA International, the Nursing Interventions Classification and the Nursing Outcome Classification; these taxonomies are the most commonly used by nurses in informatized clinical records. The purpose of this review is to synthesize the evidence on the effectiveness of the nursing process with standardized terminology using the NANDA International, the Nursing Interventions Classification and the Nursing Outcome Classification in care practice to assess the association between the presence of the related/risk factors and the clinical decision-making about nursing diagnosis, assessing the effectiveness of nursing interventions and health outcomes, and increasing people’s satisfaction. A systematic review was carried out in Medline and PreMedline (OvidSP), Embase (Embase-Elsevier), The Cochrane Library (Wiley), CINAHL (EbscoHOST), SCI-EXPANDED, SSCI and Scielo (WOS), LILACS (Health Virtual Library) and SCOPUS (SCOPUS-Elsevier) and included randomized clinical trials as well as quasi-experimental, cohort and case-control studies. Selection and critical appraisal were conducted by two independent reviewers. The certainty of the evidence was assessed with the Grading of Recommendations Assessment, Development and Evaluation Methodology. A total of 17 studies were included with variability in the level and certainty of evidence. According to the outcomes, 6 studies assessed diagnostic decision-making and 11 assessed improvements in individual health outcomes. No studies assessed improvements in intervention effectiveness or population satisfaction. There is a need to increase studies with rigorous methodologies that address clinical decision-making about nursing diagnoses using NANDA International and individuals’ health outcomes using the Nursing Interventions Classification and the Nursing Outcome Classification as well as implementing studies that assess the use of these terminologies for improvements in the effectiveness of nurses’ interventions and population satisfaction with the nursing process.
“Feeling Trapped in Prison” Due to the COVID-19 Pandemic: Perceptions and Practices among Healthcare Workers and Prison Staff from a Brazilian Maximum Security Unit
Authors: Baccon Wanessa Cristina , Salci Maria Aparecida , Carreira Lígia , Gallo Adriana Martins , Marques Francielle Renata Danielli Martins , Laranjeira Carlos
Published: September 2023

The COVID-19 pandemic had several repercussions on prison staff, but the currently available evidence has mainly ignored these effects. This qualitative study aimed to understand the impact of COVID-19 on the prison system through the narratives of health and security professionals, using the methodological framework of the constructivist grounded theory proposed by Charmaz. The sample included 10 healthcare workers and 10 security professionals. Data collection took place between October and November 2022 through individual in-depth interviews. The data were analyzed using the MaxQDA software. Three categories of interrelated data emerged: (1) “Confrontation and disruption” caused by the COVID-19 pandemic in the prison system; (2) “Between disinfodemic and solicitude” referring to the tension between information management and the practice of care centered on the needs of inmates; and, finally, (3) “Reorganization and mitigation strategies during the fight against COVID-19”. Continuous education and the development of specific skills are essential to enable professionals to face the challenges and complex demands that arise in prison contexts. The daily routines professionals had previously taken for granted were disrupted by COVID-19. Thus, investing in adequate training and emotional support programs is crucial to promote the resilience and well-being of these professionals, ensuring an efficient and quality response to critical events.
Alternative Clinical Practice Experiences of Korean Nursing Students during the COVID-19 Pandemic
Authors: Ha Eun-Ho
Published: September 2023

Background: Routine clinical practice (RCP) experiences provide nursing students with the opportunity to gain confidence in their professional roles. The purpose of this study was to explore the alternative clinical practice (ACP) experiences of nursing students during the COVID-19 pandemic using the Q methodology. Methods: Fifty-two nursing students located in four cities across South Korea participated. The participants sorted the order of and ranked 41 Q statements about their experiences with ACP into a Q sort table; the data were analyzed using the PQ method. Results: The following three distinct viewpoints were extracted: (1) ACP helps with balancing learning and life (favorable view of ACP); (2) ACP does not help with balancing theory and clinical field practice (critical view of ACP); and (3) RCP cannot be replaced by ACP (negative view of ACP). Conclusions: The findings of this study indicate that developing a curriculum for clinical practice that can enhance the strengths of ACP while compensating for its weaknesses will help promote learning among nursing students.
Role of First Trimester Screening Biochemical Markers to Predict Hypertensive Pregnancy Disorders and SGA Neonates—A Narrative Review
Authors: Górczewski Wojciech , Górecka Joanna , Massalska-Wolska Magdalena , Staśkiewicz Magdalena , Borowski Dariusz , Huras Hubert , Rybak-Krzyszkowska Magda
Published: September 2023

Early recognition of high-risk pregnancies through biochemical markers may promote antenatal surveillance, resulting in improved pregnancy outcomes. The goal of this study is to evaluate the possibilities of using biochemical markers during the first trimester of pregnancy in the prediction of hypertensive pregnancy disorders (HPD) and the delivery of small-for-gestational-age (SGA) neonates. A comprehensive search was conducted on key databases, including PubMed, Scopus, and Web of Science, for articles relating to the use of biochemical markers in the prediction of HPD and SGA. The findings show that changes in the levels of biomarkers in the early pregnancy phases could be an important indicator of adverse pregnancy outcomes. The literature shows that low PAPP-A (pregnancy-associated plasma protein A) and PlGF (placental growth factor) levels, low alkaline phosphatase (AP), higher sFlt-1 (soluble fms-like Tyrosine Kinase-1) levels, higher AFP (alfa fetoprotein) levels, and elevated levels of inflammatory markers such as β-HGC (free beta human chorionic gonadotropin), interferon-gamma (INF-γ), and tumor necrosis factor-α (TNF-α) may be associated with risks including the onset of HPD, fetal growth restriction (FGR), and delivery of SGA neonates. Comparatively, PAPP-A and PlGF appear to be the most important biochemical markers for the prediction of SGA and HPD.
Integrating Blockchain Technology into a University Graduation System
Authors: Rasheed Zainab , Mimirinis Mike
Published: September 2023

The integration of blockchain technology in educational institutions is gaining momentum due to its promise to improve the graduation system and the process of verifying educational qualifications. However, little research exists on the social aspects of incorporating blockchain technology in an educational environment. This study aims to evaluate the social impact of blockchain technology on internal and external stakeholders of a higher education institution, including educational leaders, management, graduates, and external organisations. Using the Social Impact Assessment methodology, this study reveals that the integration of blockchain technology can have an overall positive impact on industrial and alumni relations and resource optimization. This study also contributes to the literature on Social Impact Assessment by presenting a methodological model for the integration of blockchain technology in the context of a higher education environment.
Alternative Integrated Weed Management Options for Clopyralid-Resistant Common Ragweed
Authors: Gallina Greta , Cregg Bert , Patterson Eric , Hill Erin , Saha Debalina
Published: September 2023

Common ragweed (Ambrosia artemisiifolia L.) is an extremely competitive broadleaved summer annual weed found in Christmas tree production systems within Michigan. Common ragweed has been reported to have resistance to glyphosate, PSII inhibitors, PPO inhibitors, and ALS herbicides. There have been reports from Michigan Christmas tree growers of common ragweed resistance to clopyralid, a synthetic auxin herbicide, in Montcalm County, Michigan. The objective of this study was to test alternative post-emergence herbicide combinations and organic mulch on clopyralid-resistant common ragweed for weed control efficacy. The following two stages of common ragweed were used: stage 1 (6–9 leaves) and stage 2 (12–14 leaves). For common ragweed in stage 1 in 2021 and 2022, as well as stage 2 in 2022, at all evaluation dates, mulch + clopyralid + oxyfluorfen provided the highest level of weed control. For stage 1 in 2022, this treatment combination provided 100% control from 2 weeks after treatment (WAT) and always showed better or equal weed control compared to all the other treatments. The combination of mulch + clopyralid + glyphosate provided 100% control by 2 WAT when plants were treated at stage 2 in 2022. For the plants treated at stage 1 in 2022, many of the treatments reached a fresh weight of 0 g, but in 2021, those same treatments resulted in a fresh weight of around 20 g. Based on fresh weight, the greatest plant growth occurred with glyphosate treatment in 2021 and clopyralid and mulch alone in 2022. This is likely due to common ragweed’s resistance to these herbicides.
Recycled Waste Leaf Litter Pots Exhibit Excellent Biodegradability: An Experimental Analysis
Authors: Ko Daegeun , Chung Haegeun , Park Jongbae , Kim Hyungwoo , Kang Eunseo , Lee Songhee , Yoon Tae Kyung
Published: September 2023

The growth of the gardening kit market could result in the increased wasting of nursery pots, which are usually made of plastic. Replacing these pots with biodegradable pots made from green waste could have benefits for climate mitigation, the circular economy, and the greenness of gardening. To address this, we introduce a prototype recycled waste leaf litter (RWLL) nursery pot. Via an incubation experiment over 90 d, we examined their biodegradability and effects on microbial enzyme activity and inorganic nitrogen concentration, comparing them with commercially available biodegradable pots, namely peat–paper mixture pots (also known as Jiffypots®) and coco-coir pots. The effects of pot thickness were tested. Based on mass loss during incubation and on soil CO2 efflux, the RWLL pots exhibited excellent biodegradability, regardless of their thickness, with decomposition rates and soil CO2 efflux 1.5–6 times greater than other biodegradable pots. Biodegradability, extracellular enzyme activity, and soil inorganic nitrogen content were not affected by RWLL pot thickness or by the presence or absence of a plant in the soil. Unlike in natural ecosystems, leaf litter is treated as waste in urban green spaces, and its decomposition into soil organic matter is prevented. Creating plant pots from leaf litter enhances soil quality, reduces atmospheric carbon emissions, and satisfies the desire of gardeners for greenness.
A B-Box Transcription Factor CoBBX24 from Camellia oleifera Delays Leaf Senescence and Enhances Drought Tolerance in Arabidopsis
Authors: Liu Yanan , Zhu Zhiguo , Wu Yang , Gao Yinxiang , Zhang Lisha , Yu Changshuai , Ye Sicheng , Liu Wenxin
Published: September 2023

Plants face various biotic and abiotic stress factors during their growth and development, among which, drought is a serious adverse factor that affects yield and quality in agriculture and forestry. Several transcription factors are involved in regulating plant responses to drought stress. In this study, the B-box (BBX) transcription factor CoBBX24 was cloned from Camellia oleifera. This gene encodes a 241-amino-acid polypeptide containing two B-box domains at the N-terminus. A phylogenetic analysis revealed that CoBBX24 and CsBBX24 from Camellia sinensis are in the same branch, with their amino acid sequences being identical by 96.96%. CoBBX24 was localized to the nucleus and acted as a transcriptional activator. The overexpression of CoBBX24 in Arabidopsis heightened its drought tolerance along with a relatively high survival rate, and the rate of water loss in the OX-CoBBX24 lines was observably lower than that of the wild-type. Compared to the wild-type, the root lengths of the OX-CoBBX24 lines were significantly inhibited with abscisic acid. Leaf senescence was delayed in the OX-CoBBX24 lines treated with abscisic acid. The expression of genes related to leaf senescence and chlorophyll breakdown (e.g., SAG12, SAG29, NYC1, NYE1, and NYE2) was downregulated in the OX-CoBBX24 lines. This study indicated that CoBBX24 positively regulates the drought tolerance in Arabidopsis through delayed leaf senescence.
Material Challenges and Hydrogen Embrittlement Assessment for Hydrogen Utilisation in Industrial Scale
Authors: Ilyushechkin Alexander , Schoeman Liezl , Carter Lachlan , Hla San Shwe
Published: September 2023

Hydrogen has been studied extensively as a potential enabler of the energy transition from fossil fuels to renewable sources. It promises a feasible decarbonisation route because it can act as an energy carrier, a heat source, or a chemical reactant in industrial processes. Hydrogen can be produced via renewable energy sources, such as solar, hydro, or geothermic routes, and is a more stable energy carrier than intermittent renewable sources. If hydrogen can be stored efficiently, it could play a crucial role in decarbonising industries. For hydrogen to be successfully implemented in industrial systems, its impact on infrastructure needs to be understood, quantified, and controlled. If hydrogen technology is to be economically feasible, we need to investigate and understand the retrofitting of current industrial infrastructure. Currently, there is a lack of comprehensive knowledge regarding alloys and components performance in long-term hydrogen-containing environments at industrial conditions associated with high-temperature hydrogen processing/production. This review summarises insights into the gaps in hydrogen embrittlement (HE) research that apply to high-temperature, high-pressure systems in industrial processes and applications. It illustrates why it is still important to develop characterisation techniques and methods for hydrogen interaction with metals and surfaces under these conditions. The review also describes the implications of using hydrogen in large-scale industrial processes.
Relating Lake Circulation Patterns to Sediment, Nutrient, and Water Hyacinth Distribution in a Shallow Tropical Highland Lake
Authors: Kebedew Mebrahtom G. , Tilahun Seifu A. , Zimale Fasikaw A. , Belete Mulugeta A. , Wosenie Mekete D. , Steenhuis Tammo S.
Published: September 2023

Excess sediment and nutrient losses from intensifying agriculture degrade water quality and boost plant growth. The relationship between circulation patterns, spatial water quality degradation, and water hyacinth infestation is not adequately studied. The objective of this study is, therefore, to investigate the effect of lake circulation patterns on sediment and nutrient distribution and its implication on the spread of water hyacinth in a tropical lake. This study was carried out in Lake Tana, the largest freshwater lake in Ethiopia, where sediment and nutrient concentrations are increasing, and water hyacinths have become a challenge since 2011. The lake circulation pattern was simulated by the Delft3D model based on a bathymetry survey, discharge, and meteorological forcings. To predict the transport path of sediments and dissolved nutrients, an inert tracer was released in the four main river inlets of the lake. Observed lake water level measurements were used to validate the model. Our results show that the lake circulation pattern could explain the transport path of sediment and nutrients and the location of the water hyacinths found in the northeast of the lake. Sediments and nutrients from the largest river, Gilgel Abay, in the southeast of Lake Tana, flow through the two outlets nearby with little sediment deposition due to the relatively short retention time. The phosphorus-rich sediments of the 24 h at 105 °C remaining three main rivers joining the lake at the north and east are transported to the northeast. Thus, the management and control of water hyacinths should focus on the northern and eastern catchment areas of Lake Tana.
The Determination of Assistance-as-Needed Support by an Ankle–Foot Orthosis for Patients with Foot Drop
Authors: Scherb David , Steck Patrick , Wechsler Iris , Wartzack Sandro , Miehling Jörg
Published: August 2023

Patients who suffer from foot drop have impaired gait pattern functions and a higher risk of stumbling and falling. Therefore, they are usually treated with an assistive device, a so-called ankle–foot orthosis. The support of the orthosis should be in accordance with the motor requirements of the patient and should only be provided when needed, which is referred to as assistance-as-needed. Thus, in this publication, an approach is presented to determine the assistance-as-needed support using musculoskeletal human models. Based on motion capture recordings of multiple subjects performing gaits at different speeds, a parameter study varying the optimal force of a reserve actuator representing the ankle–foot orthosis added in the musculoskeletal simulation is conducted. The results show the dependency of the simulation results on the selected optimal force of the reserve actuator but with a possible identification of the assistance-as-needed support required from the ankle–foot orthosis. The required increase in support due to the increasing severity of foot drop is especially demonstrated with the approach. With this approach, information for the required support of individual subjects can be gathered, which can further be used to derive the design of an ankle–foot orthosis that optimally assists the subjects.
Ryanodine Receptor Staining Identifies Viable Cardiomyocytes in Human and Rabbit Cardiac Tissue Slices
Authors: Pfeuffer Ann-Katrin M. , Küpfer Linda K. , Shankar Thirupura S. , Drakos Stavros G. , Volk Tilmann , Seidel Thomas
Published: August 2023

In terms of preserving multicellularity and myocardial function in vitro, the cultivation of beating myocardial slices is an emerging technique in basic and translational cardiac research. It can be used, for example, for drug screening or to study pathomechanisms. Here, we describe staining for viable cardiomyocytes based on the immunofluorescence of ryanodine receptors (RyRs) in human and rabbit myocardial slices. Biomimetic chambers were used for culture and measurements of contractile force. Fixable fluorophore-conjugated dextran, entering cells with a permeable membrane, was used for death staining. RyRs, nuclei and the extracellular matrix, including the t-system, were additionally stained and analyzed by confocal microscopy and image processing. We found the mutual exclusion of the RyR and dextran signals in cultivated slices. T-System density and nucleus size were reduced in RyR-negative/dextran-positive myocytes. The fraction of RyR-positive myocytes and pixels correlated with the contractile force. In RyR-positive/dextran-positive myocytes, we found irregular RyR clusters and SERCA distribution patterns, confirmed by an altered power spectrum. We conclude that RyR immunofluorescence indicates viable cardiomyocytes in vibratome-cut myocardial slices, facilitating the detection and differential structural analysis of living vs. dead or dying myocytes. We suggest the loss of sarcoplasmic reticulum integrity as an early event during cardiomyocyte death.
Conjugative Plasmid pPPUT-Tik1-1 from a Permafrost Pseudomonas putida Strain and Its Present-Day Counterparts Inhabiting Environments and Clinics
Authors: Maslova Olga , Beletsky Alexey , Mindlin Sofia , Petrova Nika , Mardanov Andrey , Petrova Mayya
Published: August 2023

A novel group of conjugative plasmids of Pseudomonas is characterized. The prototype plasmid pPPUT-Tik1-1 (153,663 bp), isolated from a permafrost strain of P. putida Tik1, carries a defective mercury transposon, Tn501, and a streptomycin resistance transposon, Tn5393. Ten plasmids and 34 contigs with backbone regions closely related to pPPUT-Tik1-1 have been found in GenBank. Two of these plasmids from clinical strains of P. putida and P. fulva are almost identical to the ancient plasmid. A characteristic feature of this group of plasmids is the presence of two genes encoding the initiators of replication (repA1 and repA2). None of these genes have high similarity with plasmid replication genes belonging to known incompatibility groups. It has been demonstrated that while pPPUT-Tik1-1-like plasmids have homologous backbone regions, they significantly differ by the molecular structure and the predicted functions of their accessory regions. Some of the pPPUT-Tik1-1-related plasmids carry determinants of antibiotic resistance and/or heavy metal salts. Some plasmids are characterized by the ability to degrade xenobiotics. Plasmids related to pPPUT-Tik1-1 are characterized by a narrow host range and are found in various species of the Pseudomonas genus. Interestingly, we also found shorter plasmid variants containing the same replication module, but lacking conjugation genes and containing other structural changes that strongly distinguish them from plasmids related to pPPUT-Tik1-1, indicating that the structure of the replication module cannot be used as the sole criterion for classifying plasmids. Overall, the results suggest that the plasmids of the novel group can be spread using conjugation in environmental and clinical strains of Pseudomonas and may play diverse adaptive functions due to the presence of various accessory regions.
n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung–Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout
Authors: Hernandez Jessica , Schäffer Julia , Herden Christiane , Pflieger Fabian Johannes , Reiche Sylvia , Körber Svenja , Kitagawa Hiromu , Welter Joelle , Michels Susanne , Culmsee Carsten , Bier Jens , Sommer Natascha , Kang Jing X. , Mayer Konstantin , Hecker Matthias , Rummel Christoph
Published: August 2023

Specialized pro-resolving mediators (SPMs) and especially Resolvin E1 (RvE1) can actively terminate inflammation and promote healing during lung diseases such as acute respiratory distress syndrome (ARDS). Although ARDS primarily affects the lung, many ARDS patients also develop neurocognitive impairments. To investigate the connection between the lung and brain during ARDS and the therapeutic potential of SPMs and its derivatives, fat-1 mice were crossbred with RvE1 receptor knockout mice. ARDS was induced in these mice by intratracheal application of lipopolysaccharide (LPS, 10 µg). Mice were sacrificed at 0 h, 4 h, 24 h, 72 h, and 120 h post inflammation, and effects on the lung, liver, and brain were assessed by RT-PCR, multiplex, immunohistochemistry, Western blot, and LC-MS/MS. Protein and mRNA analyses of the lung, liver, and hypothalamus revealed LPS-induced lung inflammation increased inflammatory signaling in the hypothalamus despite low signaling in the periphery. Neutrophil recruitment in different brain structures was determined by immunohistochemical staining. Overall, we showed that immune cell trafficking to the brain contributed to immune-to-brain communication during ARDS rather than cytokines. Deficiency in RvE1 receptors and enhanced omega-3 polyunsaturated fatty acid levels (fat-1 mice) affect lung–brain interaction during ARDS by altering profiles of several inflammatory and lipid mediators and glial activity markers.
Investigation and Comparison of Active and Passive Encapsulation Methods for Loading Proteins into Liposomes
Authors: Pisani Silvia , Di Martino Deborah , Cerri Silvia , Genta Ida , Dorati Rossella , Bertino Giulia , Benazzo Marco , Conti Bice
Published: August 2023

In this work, four different active encapsulation methods, microfluidic (MF), sonication (SC), freeze–thawing (FT), and electroporation (EP), were investigated to load a model protein (bovine serum albumin—BSA) into neutral liposomes made from 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC):cholesterol (Chol) and charged liposomes made from DSPC:Chol:Dioleoyl-3-trimethylammonium propane (DOTAP), DSPC:Chol:1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), and DSPC:Chol:phosphatidylethanolamine (PE). The aim was to increase the protein encapsulation efficiency (EE%) by keeping the liposome size below 200 nm and the PDI value below 0.7, which warrants a nearly monodisperse preparation. Electroporation (100 V) yielded the best results in terms of EE%, with a dramatic increase in liposome size (>600 nm). The FT active-loading method, either applied to neutral or charged liposomes, allowed for obtaining suitable EE%, keeping the liposome size range below 200 nm with a suitable PDI index. Cationic liposomes (DSPC:Chol:DOTAP) loaded with the FT active method showed the best results in terms of EE% (7.2 ± 0.8%) and size (131.2 ± 11.4 nm, 0.140 PDI). In vitro release of BSA from AM neutral and charged liposomes resulted slower compared to PM liposomes and was affected by incubation temperature (37 °C, 4 °C). The empty charged liposomes tested for cell viability on Human Normal Dermal Fibroblast (HNDF) confirmed their cytocompatibility also at high concentrations (1010 particles/mL) and cellular uptake at 4 °C and 37 °C. It can be concluded that even if both microfluidic passive and active methods are more easily transferable to an industrial scale, the FT active-loading method turned out to be the best in terms of BSA encapsulation efficiencies, keeping liposome size below 200 nm.
Improving Multiclass Classification of Fake News Using BERT-Based Models and ChatGPT-Augmented Data
Authors: Shushkevich Elena , Alexandrov Mikhail , Cardiff John
Published: September 2023

Given the widespread accessibility of content creation and sharing, false information proliferation is a growing concern. Researchers typically tackle fake news detection (FND) in specific topics using binary classification. Our study addresses a more practical FND scenario, analyzing a corpus with unknown topics through multiclass classification, encompassing true, false, partially false, and other categories. Our contribution involves: (1) exploring three BERT-based models—SBERT, RoBERTa, and mBERT; (2) enhancing results via ChatGPT-generated artificial data for class balance; and (3) improving outcomes using a two-step binary classification procedure. Our focus is on the CheckThat! Lab dataset from CLEF-2022. Our experimental results demonstrate a superior performance compared to existing achievements but FND’s practical use needs improvement within the current state-of-the-art.
ST-Segment Elevation: An Unexpected Culprit
Authors: Sá Couto David , Alexandre André , Costa Ricardo , Campinas Andreia , Santos Mariana , Ribeiro Diana , Torres Severo , Luz André
Published: September 2023

The clinical presentation of pulmonary embolism (PE) and acute coronary syndrome can be similar. We report a case of a patient presenting with antero-septal ST-segment elevation after cardiac arrest, found to have acute-PE-mimicking ST-segment elevation myocardial infarction (STEMI), treated with aspiration thrombectomy and catheter-directed thrombolysis (CDT). A 78-year-old man was admitted with dyspnea, chest pain and tachycardia. During evaluation, cardiac arrest in pulseless electrical activity was documented. Advanced life support was started immediately. ECG post-ROSC revealed ST-segment elevation in V1–V4 and aVR. Echocardiography showed normal left ventricular function but right ventricular (RV) dilation and severe dysfunction. The patient was in shock and was promptly referred to cardiac catheterization that excluded significant CAD. Due to the discordant ECG and echocardiogram findings, acute PE was suspected, and immediate invasive pulmonary angiography revealed bilateral massive pulmonary embolism. Successful aspiration thrombectomy was performed followed by local alteplase infusion. At the end of the procedure, mPAP was reduced and blood pressure normalized allowing withdrawal of vasopressor support. Twenty-four-hour echocardiographic reassessment showed normal-sized cardiac chambers with preserved biventricular systolic function. Bedside echocardiography in patients with ST-segment elevation post-ROSC is instrumental in raising the suspicion of acute PE. In the absence of a culprit coronary lesion, prompt pulmonary angiography should be considered if immediately feasible. In these cases, CDT and aspiration in high-risk acute PE seem safe and effective in relieving obstructive shock and restoring hemodynamics.
Reply to Schimmelbusch, K.J.; Collison, F.T. Comment on “Rosa et al. Optic Nerve Drusen Evaluation: A Comparison between Ultrasound and OCT. J. Clin. Med. 2022, 11, 3715”
Authors: Rosa Nicola , De Bernardo Maddalena , Abbinante Giulia , Vecchio Gianluca , Capasso Luigi , Cione Ferdinando
Published: September 2023

We appreciate the comments of Schimmelbusch et al. [...]
Analysis of P(v-a)CO2/C(a-v)O2 Ratio and Other Perfusion Markers in a Population of 98 Pediatric Patients Undergoing Cardiac Surgery
Authors: Taiana Matteo , Tomasella Irene , Russo Alessandro , Lerose Annalisa , Ceola Graziadei Marcello , Corubolo Luisa , Rama Jacopo , Schweiger Vittorio , Vignola Alessandro , Polati Enrico , Luciani Giovanni Battista , Onorati Francesco , Donadello Katia , Gottin Leonardo
Published: September 2023

Background: The so-called Low Cardiac Output Syndrome (LCOS) is one of the most common complications in pediatric patients with congenital heart disease undergoing corrective surgery. LCOS requires high concentrations of inotropes to support cardiac contractility and improve cardiac output, allowing for better systemic perfusion. To date, serum lactate concentrations and central venous oxygen saturation (ScVO2) are the most commonly used perfusion markers, but they are not completely reliable in identifying a state of global tissue hypoxia. The study aims to evaluate whether the venoarterial carbon dioxide difference/arterial-venous oxygen difference ratio [P(v-a)CO2/C(a-v)O2] can be a good index to predict the development of LCOS in the aforementioned patients, so as to treat it promptly. Methods: This study followed a population of 98 children undergoing corrective cardiac surgery from June 2018 to October 2020 at the Department of Cardiac Surgery of University Hospital Integrated Trust and their subsequent admission at the Postoperative Cardiothoracic Surgery Intensive Care Unit. During the study, central arterial and venous blood gas analyses were carried out before and after cardiopulmonary bypass (CPB) (pre-CPB and post-CPB), at admission to the intensive care unit, before and after extubation, and at any time of instability or modification of the patient’s clinical and therapeutic conditions. Results: The data analysis shows that 46.9% of the children developed LCOS (in line with the current literature) but that there is no statistically significant association between the P(v-a)CO2/C(a-v)O2 ratio and LCOS onset. Despite the limits of statistical significance, however, a 31% increase in the ratio emerged from the pre-CPB phase to the post-CPB phase when LCOS is present. Conclusions: This study confirms a statistically significant association between the most used markers in adult patients (serum lactate concentration, ScVO2, and oxygen extraction ratio—ERO2) measured in the pre-CPB phase and the incidence of LCOS onset, especially in patients with hemodynamic instability before surgery.
Revisiting Diagnosis and Treatment of Hypertrophic Cardiomyopathy: Current Practice and Novel Perspectives
Authors: Ottaviani Andrea , Mansour Davide , Molinari Lorenzo V. , Galanti Kristian , Mantini Cesare , Khanji Mohammed Y. , Chahal Anwar A. , Zimarino Marco , Renda Giulia , Sciarra Luigi , Pelliccia Francesco , Gallina Sabina , Ricci Fabrizio
Published: September 2023

Sarcomeric hypertrophic cardiomyopathy (HCM) is a prevalent genetic disorder characterised by left ventricular hypertrophy, myocardial disarray, and an increased risk of heart failure and sudden cardiac death. Despite advances in understanding its pathophysiology, treatment options for HCM remain limited. This narrative review aims to provide a comprehensive overview of current clinical practice and explore emerging therapeutic strategies for sarcomeric HCM, with a focus on cardiac myosin inhibitors. We first discuss the conventional management of HCM, including lifestyle modifications, pharmacological therapies, and invasive interventions, emphasizing their limitations and challenges. Next, we highlight recent advances in molecular genetics and their potential applications in refining HCM diagnosis, risk stratification, and treatment. We delve into emerging therapies, such as gene editing, RNA-based therapies, targeted small molecules, and cardiac myosin modulators like mavacamten and aficamten, which hold promise in modulating the underlying molecular mechanisms of HCM. Mavacamten and aficamten, selective modulators of cardiac myosin, have demonstrated encouraging results in clinical trials by reducing left ventricular outflow tract obstruction and improving symptoms in patients with obstructive HCM. We discuss their mechanisms of action, clinical trial outcomes, and potential implications for the future of HCM management. Furthermore, we examine the role of precision medicine in HCM management, exploring how individualised treatment strategies, including exercise prescription as part of the management plan, may optimise patient outcomes. Finally, we underscore the importance of multidisciplinary care and patient-centred approaches to address the complex needs of HCM patients. This review also aims to encourage further research and collaboration in the field of HCM, promoting the development of novel and more effective therapeutic strategies, such as cardiac myosin modulators, to hopefully improve the quality of life and outcome of patients with sarcomeric HCM.
First-Generation iStent Bypass Implantation versus ab Externo Canaloplasty Combined with Phacoemulsification in Patients with Primary Open Angle Glaucoma—12-Month Follow-Up
Authors: Gołaszewska Kinga , Obuchowska Iwona , Konopińska Joanna
Published: September 2023

This prospective, non-randomized, interventional clinical study evaluated the efficacy and safety profile of first-generation iStent bypass implantation versus ab externo canaloplasty, both combined with phacoemulsification, in patients with primary open-angle glaucoma (POAG) after 12-month follow-up. A total of 138 patients with POAG and their 138 eyes (69 phaco-iStent and 69 phacocanaloplasty) were included. Postoperatively at 12 months, the mean intraocular pressure (IOP) decreased from 18.44 ± 3.88 to 15.51 ± 2.50 mmHg and from 17.20 ± 4.04 to 14.97 ± 2.37 mmHg in the phaco-iStent (PiS) and phacocanaloplasty (PC) groups, respectively (p = 0.480). In both groups, 35.7% achieved >20% IOP reduction from baseline. A total of 86% and 71.4% of the eyes were medication-free at 12 months in the PiS and PC groups, respectively. In both groups, all eyes showed improvement in best-corrected visual acuity compared with baseline and demonstrated similar safety profiles throughout the 12-month follow-up period. This study showed equal hypotensive effects of PiS and PC. Both procedures significantly reduced the IOP and the requirement for IOP-lowering medications for at least 12 months postoperatively, with no significant differences between the groups.
Artificial Intelligence in Predicting Mechanical Properties of Composite Materials
Authors: Kibrete Fasikaw , Trzepieciński Tomasz , Gebremedhen Hailu Shimels , Woldemichael Dereje Engida
Published: September 2023

The determination of mechanical properties plays a crucial role in utilizing composite materials across multiple engineering disciplines. Recently, there has been substantial interest in employing artificial intelligence, particularly machine learning and deep learning, to accurately predict the mechanical properties of composite materials. This comprehensive review paper examines the applications of artificial intelligence in forecasting the mechanical properties of different types of composites. The review begins with an overview of artificial intelligence and then outlines the process of predicting material properties. The primary focus of this review lies in exploring various machine learning and deep learning techniques employed in predicting the mechanical properties of composites. Furthermore, the review highlights the theoretical foundations, strengths, and weaknesses of each method used for predicting different mechanical properties of composites. Finally, based on the findings, the review discusses key challenges and suggests future research directions in the field of material properties prediction, offering valuable insights for further exploration. This review is intended to serve as a significant reference for researchers engaging in future studies within this domain.
3D Printing of Low-Filled Basalt PA12 and PP Filaments for Automotive Components
Authors: Lupone Federico , Tirillò Jacopo , Sarasini Fabrizio , Badini Claudio , Sergi Claudia
Published: September 2023

Fused Deposition Modeling (FDM) enables many advantages compared to traditional manufacturing techniques, but the lower mechanical performance due to the higher porosity still hinders its industrial spread in key sectors like the automotive industry. PP and PA12 filaments filled with low amounts of basalt fibers were produced in the present work to improve the poor mechanical properties inherited from the additive manufacturing technique. For both matrices, the introduction of 5 wt.% of basalt fibers allows us to achieve stiffness values comparable to injection molding ones without modifying the final weight of the manufactured components. The increased filament density compared with the neat polymers, upon the introduction of basalt fibers, is counterbalanced by the intrinsic porosity of the manufacturing technique. In particular, the final components are characterized by a 0.88 g/cm3 density for PP and 1.01 g/cm3 for PA12 basalt-filled composites, which are comparable to the 0.91 g/cm3 and 1.01 g/cm3, respectively, of the related neat matrix used in injection molding. Some efforts are still needed to fill the gap of 15–28% for PP and of 26.5% for PA12 in tensile strength compared to injection-molded counterparts, but the improvement of the fiber/matrix interface by fiber surface modification or coupling agent employment could be a feasible solution.
A New α + β Ti-15Nb Alloy with Low Elastic Modulus: Characterization and In Vitro Evaluation on Osteogenic Phenotype
Authors: Donato Tatiani Ayako Goto , Sousa Karolyne dos Santos Jorge , Kuroda Pedro Akira Bazaglia , Grandini Carlos Roberto
Published: September 2023

This study aimed to produce Ti-15Nb alloy with a low elastic modulus, verify its biocompatibility, and determine whether the alloy indirectly influences cellular viability and morphology, as well as the development of the osteogenic phenotype in cells cultured for 2, 3, and 7 days derived from rat calvarias. Two heat treatments were performed to modify the mechanical properties of the alloy where the Ti-15Nb alloy was heated to 1000 °C followed by slow (−5 °C/min) (SC) and rapid cooling (RC). The results of structural and microstructural characterization (XRD and optical images) showed that the Ti-15Nb alloy was of the α + β type, with slow cooling promoting the formation of the α phase and rapid cooling the formation of the β phase, altering the values for the hardness and elastic modulus. Generally, a more significant amount of the α phase in the Ti-15Nb alloy increased the elastic modulus value but decreased the microhardness value. After the RC treatment, the results demonstrated that the Ti-15Nb alloy did not present cytotoxic effects on the osteogenic cells. In addition, we did not find variations in the cell quantity in the microscopy results that could suggest cell adhesion or proliferation modification.
Synthesis, Physicochemical Characteristics, and Biocompatibility of Multi-Component Collagen-Based Hydrogels Developed by E-Beam Irradiation
Authors: Demeter Maria , Negrescu Andreea Mariana , Calina Ion , Scarisoreanu Anca , Albu Kaya Mădălina , Micutz Marin , Dumitru Marius , Cimpean Anisoara
Published: September 2023

Herein, three different recipes of multi-component hydrogels were synthesized by e-beam irradiation. These hydrogels were obtained from aqueous polymer mixtures in which different proportions of bovine collagen gel, sodium carboxymethylcellulose (CMC), poly(vinylpyrrolidone), chitosan, and poly(ethylene oxide) were used. The cross-linking reaction was carried out exclusively by e-beam cross-linking at 25 kGy, a dose of irradiation sufficient both to complete the cross-linking reaction and effective for hydrogel sterilization. The hydrogels developed in this study were tested in terms of physical and chemical stability, mechanical, structural, morphological, and biological properties. They are transparent, maintain their structure, are non-adhesive when handling, and most importantly, especially from the application point of view, have an elastic structure. Likewise, these hydrogels possessed different swelling degrees and expressed rheological behavior characteristic of soft solids with permanent macromolecular network. Morphologically, collagen- and CMC based-hydrogels showed porous structures with homogeneously distributed pores assuring a good loading capacity with drugs. These hydrogels were investigated by indirect and direct contact studies with Vero cell line (CCL-81™, ATCC), demonstrating that they are well tolerated by normal cells and, therefore, showed promising potential for further use in the development of drug delivery systems based on hydrogels.
Effects of Peer-Supported and Self-Guided Exercise on Self-Reported Anxiety and Depression among Young Adults—A Pilot Study
Authors: Zhu Xihe , Kostick Michael D. , Haegele Justin A.
Published: September 2023

Mental health conditions such as anxiety and depression became heightened issues for college-aged young adults during the global pandemic. The main purpose of this study was to examine the effects of a peer-supported exercise intervention on young adults (vs. self-guided exercise) who reported elevated levels of anxiety and/or depression. A parallel group design was used where young adults (n = 27) were randomly assigned to either a peer-supported or self-guided exercise group which lasted for eight weeks. The generalized anxiety and depression subscales of the Counseling Center Assessment of Psychological Symptoms (CCAPS-34) were measured for a baseline and then at 4-week, 8-week, and 12-week follow-up. Analyses of covariance (ANCOVA) with repetitive measures show that peer-supported and self-guided exercise programs reduced participant anxiety and depression scores; however, intervention decay for the peer-supported exercise intervention was more severe than that for the self-guided group. Self-guided exercise had a longer-lasting effect than the peer-supported alternative and could be a cost-effective approach to combat anxiety and depression issues among young adults.
Estimating Local Structural Equation Models
Authors: Robitzsch Alexander
Published: September 2023

Local structural equation models (LSEM) are structural equation models that study model parameters as a function of a moderator. This article reviews and extends LSEM estimation methods and discusses the implementation in the R package sirt. In previous studies, LSEM was fitted as a sequence of models separately evaluated as each value of the moderator variables. In this article, a joint estimation approach is proposed that is a simultaneous estimation method across all moderator values and also allows some model parameters to be invariant with respect to the moderator. Moreover, sufficient details on the main estimation functions in the R package sirt are provided. The practical implementation of LSEM is demonstrated using illustrative datasets and an empirical example. Moreover, two simulation studies investigate the statistical properties of parameter estimation and significance testing in LSEM.
In Situ Observation of Near-Surface Wind Seasonal Variation on the Southern Coast of Sri Lanka
Authors: Lu Xuancheng , Huang Shuyun , Wang Dongxiao , Luo Yao , Gamage Tilak Priyadarshana , Kumara P. B. Terney Pradeep
Published: September 2023

The characteristics of local surface wind are closely related to the assessment of wind power resources and the oscillation period of offshore wind turbines. In this research, we analyzed near-surface wind observation data from the southern coast of Sri Lanka, comparing the surface wind variation characteristics across different seasons. Through spectral analysis, we discuss the wind stability and oscillation period, aiming to provide information for the management strategies and oscillation issues of offshore wind turbines in the North Equatorial Indian Ocean to ensure their stable operation. Our findings showed that the Indian summer monsoon dominated the seasonal surface wind variation in the southern coast of Sri Lanka. The local monsoon period began in mid-May and ended in mid-October, during which stable southwest winds prevailed with an average maximum 10 m wind speed exceeding 6.0 m/s. In contrast, surface wind was unstable and weaker during autumn and winter. The surface wind speed exhibited a clear diurnal oscillation throughout the year. The wind speed power spectral density exhibited clear peaks at periods of 24 h, 12 h, and 6 h.