bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimal Dimensions of a Semisubmersible Floating Platform for a 10 MW Wind Turbine
Authors: Ferri Giulio , Marino Enzo , Borri Claudio
Published: June 2020

In this paper, an optimal semisubmersible platform is sought considering two key geometry variables: the diameter of the outer cylinders and their radial distance from the platform centre. The goal is to identify a platform configuration able to most efficiently contrast the combined wind-wave action, keeping the platform dimensions as small as possible. The amplitude of the Response Amplitude Operator (RAO) peaks and the integral area of the RAOs in a range of excited frequencies for the selected degrees of freedom are chosen as targets to be minimised. Through an efficient frequency domain simulation approach, we show that upscaling techniques proposed in the literature may lead to overdesigned platforms and that smaller and more performing platforms can be identified. In particular, the optimised platform shows a reduction of about 51% in parked and 54% in power production of the heave RAO peak, and a reduction of about 37% in parked and 50% in power production of the pitch RAO.
Log Truck Value Analysis from Increased Rail Usage
Authors: Ko Sangpil , Lautala Pasi , Zhang Kuilin
Published: June 2020

Over the past several decades, the transportation of raw materials (logs) has increasingly shifted from the railway to trucks. However, the long-term sustainability of this shift is being questioned due to the shortage of truck drivers, fluctuation of fuel prices, and changes in hours of service laws. The industry is interested in the possibility to shift more logs back to the railway but the impact of such a shift on truckers has not been investigated. This study attempted to quantify the impact of such a change on the operations of log truckers by calculating time efficiency (percentage of daily hours of service for revenue activities) and value efficiency (average loaded versus total ton-kilometers per day) between a truck only and multimodal (truck/rail) alternatives. We used actual data from the forest products industry companies and truck performance data from an earlier study to investigate the impact through case studies in four different locations of the upper Midwest, US. The results of our analysis revealed that in three out of our four case studies, re-routing log movements through rail yard/siding improved the time efficiency and value efficiency. Finally, our sensitivity analysis found that increases in average truck speed and maximum hours or service had higher impact on multimodal transportation than in truck-only system.
The Role of Population and Half-Sib Family on Driving Suitable Functional Traits for Quercus suber L. Forest Restoration
Authors: Morcillo Luna , Moutahir Hassane , Cortina Jordi , Vilagrosa Alberto
Published: June 2020

Research Highlights: Seedlings of different Quercus suber L. populations and half-sib families differ in their response to multiple stressors, which may have consequences on the future distribution of this Mediterranean species. Background and Objectives: Global change will likely increase the frequency and severity of drought in drylands. Plant species’ distributions will largely depend on their ability to respond to the combined effect of drought and other environmental stressors. Genetic diversity in morpho-functional traits are key components of this response. Yet, information on the response to multiple stresses is scarce for many iconic species. The present study assessed the variability in the response of populations and half-sib families of a Mediterranean acidophilous tree, cork oak, to drought and changes in soil conditions. Materials and Methods: We sampled acorns of half-sib families from two cork oak populations genetically introgressed with the alkaline-tolerant species Quercus ilex L., and from a non-introgressed cork oak population located in its core habitat. We germinated the acorns and subjected seedlings to contrasted levels of water availability and additions of calcium and magnesium carbonate, and assessed their morpho-physiological response. Results: Response to drought and soil chemistry composition differed between populations and families. For some traits, introgressed populations responded similarly to drought than the non-introgressed population. Conversely, the response to soil chemistry was not clearly related to introgression. When considering half-sib families within populations, the population effect diminished, which revealed the importance of intra-population variation. However, relevant traits for water scarcity adaptations, such as specific leaf area and root:shoot ratio, remained significantly different at the population level, which highlights the relevance of these traits for management. Conclusions: Our study shows that the adaptive management and restoration of cork oak forests should consider not only geographic provenances, but also half-sib lines within populations.
Cascade Use of Wood in the Czech Republic
Authors: Babuka Róbert , Sujová Andrea , Kupčák Václav
Published: June 2020

Research Highlights: One of the priorities of the European Commission is to build up an effective circular economy based on recycling and multiple use of materials. Wood biomass is a renewable raw material and can be used several times in a cascading sequence. Each country has a unique situation regarding the availability and utilization of wood sources. Background and Objectives: The objective of this study was to analyze wood flow in the Czech Republic using the cascading principle of biomass use. The specific situation in the Czech Republic lies in a lack of valid and reliable input data from official statistics. Therefore, the reverse input method was applied. Materials and Methods: Input data analyses of roundwood sources and foreign trade were based on official statistical data. The calculation of raw wood volume consumption in primary processing was performed based on the data after our own correction and recalculation. It was then possible to build up a basic model of multi-stage cascade wood use. The input volume of roundwood was divided among all types of primary processing production using conversion factors. Results: Cascading use of wood (CUW) showed the level of efficiency of the resource. Official statistical input data and the reversed input data regarding raw wood volume entering wood processing revealed differences at a level of 27%. The overall CUW in the Czech Republic indicates a high rate of wood use in primary processing with low added value and in generating energy. Conclusions: The reverse input method reveals the real situation of wood consumption irrespective of the level of official statistical data. It is suitable to apply in an environment of incomplete or incorrect input data. CUW in Czechia showed an opportunity for increasing the efficiency of wood utilization. The structure of wood use needs to be optimized towards creating greater added value.
Nuclear Functions of TOR: Impact on Transcription and the Epigenome
Authors: Laribee R. Nicholas , Weisman Ronit
Published: June 2020

The target of rapamycin (TOR) protein kinase is at the core of growth factor- and nutrient-dependent signaling pathways that are well-known for their regulation of metabolism, growth, and proliferation. However, TOR is also involved in the regulation of gene expression, genomic and epigenomic stability. TOR affects nuclear functions indirectly through its activity in the cytoplasm, but also directly through active nuclear TOR pools. The mechanisms by which TOR regulates its nuclear functions are less well-understood compared with its cytoplasmic activities. TOR is an important pharmacological target for several diseases, including cancer, metabolic and neurological disorders. Thus, studies of the nuclear functions of TOR are important for our understanding of basic biological processes, as well as for clinical implications.
Cytotoxicity and Mutagenicity of Narrowband UVB to Mammalian Cells
Authors: Buglewicz Dylan J. , Mussallem Jacob T. , Haskins Alexis H. , Su Cathy , Maeda Junko , Kato Takamitsu A.
Published: June 2020

Phototherapy using narrowband ultraviolet-B (NB-UVB) has been shown to be more effective than conventional broadband UVB (BB-UVB) in treating a variety of skin diseases. To assess the difference in carcinogenic potential between NB-UVB and BB-UVB, we investigated the cytotoxicity via colony formation assay, genotoxicity via sister chromatid exchange (SCE) assay, mutagenicity via hypoxanthine phosphoribosyltransferase (HPRT) mutation assay, as well as cyclobutane pyrimidine dimer (CPD) formation and reactive oxygen species (ROS) generation in Chinese hamster ovary (CHO) and their NER mutant cells. The radiation dose required to reduce survival to 10% (D10 value) demonstrated BB-UVB was 10 times more cytotoxic than NB-UVB, and revealed that NB-UVB also induces DNA damage repaired by nucleotide excision repair. We also found that BB-UVB more efficiently induced SCEs and HPRT mutations per absorbed energy dosage (J/m2) than NB-UVB. However, SCE and HPRT mutation frequencies were observed to rise in noncytotoxic dosages of NB-UVB exposure. BB-UVB and NB-UVB both produced a significant increase in CPD formation and ROS formation (p < 0.05); however, higher dosages were required for NB-UVB. These results suggest that NB-UVB is less cytotoxic and genotoxic than BB-UVB, but can still produce genotoxic effects even at noncytotoxic doses.
Structural and Functional Heat Stress Responses of Chloroplasts of Arabidopsis thaliana
Authors: Paul Puneet , Mesihovic Anida , Chaturvedi Palak , Ghatak Arindam , Weckwerth Wolfram , Böhmer Maik , Schleiff Enrico
Published: June 2020

Temperature elevations constitute a major threat to plant performance. In recent years, much was learned about the general molecular mode of heat stress reaction of plants. The current research focuses on the integration of the knowledge into more global networks, including the reactions of cellular compartments. For instance, chloroplast function is central for plant growth and survival, and the performance of chloroplasts is tightly linked to the general status of the cell and vice versa. We examined the changes in photosynthesis, chloroplast morphology and proteomic composition posed in Arabidopsis thaliana chloroplasts after a single or repetitive heat stress treatment over a period of two weeks. We observed that the acclimation is potent in the case of repetitive application of heat stress, while a single stress results in lasting alterations. Moreover, the physiological capacity and its adjustment are dependent on the efficiency of the protein translocation process as judged from the analysis of mutants of the two receptor units of the chloroplast translocon, TOC64, and TOC33. In response to repetitive heat stress, plants without TOC33 accumulate Hsp70 proteins and plants without TOC64 have a higher content of proteins involved in thylakoid structure determination when compared to wild-type plants.
Transcription Analysis of the Chemerin Impact on Gene Expression Profile in the Luteal Cells of Gilts
Authors: Makowczenko Karol G. , Jastrzebski Jan P. , Szeszko Karol , Smolinska Nina , Paukszto Lukasz , Dobrzyn Kamil , Kiezun Marta , Rytelewska Edyta , Kaminska Barbara , Kaminski Tadeusz
Published: June 2020

Chemerin is a recently discovered adipokine that participates in the regulation of many physiological and disorder-related processes in mammals, including metabolism, inflammatory reactions, obesity, and reproduction. We investigated how chemerin affects the transcriptome profile of porcine luteal cells. The luteal cells were acquired from mature gilts. After the in vitro culturing with and without chemerin, the total RNAs were isolated and high-throughput sequencing was performed. Obtained datasets were processed using bioinformatic tools. The study revealed 509 differentially expressed genes under the chemerin influence. Their products take part in many processes, important for the functions of the corpus luteum, such as steroids and prostaglandins synthesis, NF-κB and JAK/STAT signal transducing pathways, and apoptosis. The expression of the CASP3, HSD3B7, IL1B, and PTGS2 genes, due to their important role in the physiology of the corpus luteum, was validated using the quantitative real-time polymerase chain reaction (qPCR) method. The qPCR confirmed the changes of gene expression. Chemerin in physiological concentrations significantly affects the expression of many genes in luteal cells of pigs, which is likely to result in modification of physiological processes related to reproduction.
Conservation Assessment of the State Goat Farms by Using SNP Genotyping Data
Authors: Islam Rabiul , Liu Zhangfa , Li Yefang , Jiang Lin , Ma Yuehui
Published: June 2020

Conservation of genetic resources is of great concern globally to maintain genetic diversity for sustainable food security. Comprehensive identification of the breed composition, estimation of inbreeding and effective population size are essential for the effective management of farm animal genetic resources and to prevent the animals from genetic erosion. The Zhongwei male (ZWM), Arbas Cashmere male (ACM) and Jining Grey male (JGM) goats are conserved in three different state goat farms in China but their family information, level of inbreeding and effective population size are unknown. We investigated the genomic relationship, inbreeding coefficient and effective population size in these three breeds from three state goat farms using the Illumina goat SNP50 BeadChip. Genomic relationships and phylogenetic analysis revealed that the breeds are clearly separated and formed separate clusters based on their genetic relationship. We obtained a high proportion of informative SNPs, ranging from 91.8% in the Arbas Cashmere male to 96.2% in the Jining Grey male goat breeds with an average mean of 96.8%. Inbreeding, as measured by FROH, ranged from 1.79% in ZWM to 8.62% in ACM goat populations. High FROH values, elevated genomic coverage of very long ROH (>30 Mb) and severe decline in effective population size were recorded in ACM goat farm. The existence of a high correlation between FHOM and FROH indicates that FROH can be used as an alternative to inbreeding estimates in the absence of pedigree records. The Ne estimates 13 generations ago were 166, 69 and 79 for ZWM, ACM and JGM goat farm, respectively indicating that these goat breeds were strongly affected by selection pressure or genetic drift. This study provides insight into the genomic relationship, levels of inbreeding and effective population size in the studied goat populations conserved in the state goat farms which will be valuable in prioritizing populations for conservation and for developing suitable management practices for further genetic improvement of these Chinese male goats.
Structural Quality of Services and Use of Family Planning Services in Primary Health Care Facilities in Ethiopia. How Do Public and Private Facilities Compare?
Authors: Tessema Gizachew Assefa , Mahmood Mohammad Afzal , Gomersall Judith Streak , Assefa Yibeltal , Zemedu Theodros Getachew , Kifle Mengistu , Laurence Caroline O.
Published: June 2020

Background: Family planning (FP) is among the important interventions that reduce maternal mortality. Poor quality FP service is associated with lower services utilisation, in turn undermining the efforts to address maternal mortality. There is currently little research on the quality of FP services in the private sector in Ethiopia, and how it compares to FP services in public facilities. Methods: A secondary data analysis of two national surveys, Ethiopia Services Provision Assessment Plus Survey 2014 and Ethiopian Demographic and Health Survey 2016, was conducted. Data from 1094 (139 private, 955 public) health facilities were analysed. In total, 3696 women were included in the comparison of users’ characteristics. Logistic regression was conducted. Facility type (public vs. private) was the key exposure of interest. Results: The private facilities were less likely to have implants (Adjusted Odds Ratio (AOR) = 0.06; 95% Confidence Interval (CI): 0.03, 0.12), trained FP providers (AOR = 0.23; 95% CI: 0.14, 0.41) and FP guidelines/protocols (AOR = 0.33; 95% CI: 0.19, 0.54) than public facilities but were more likely to have functional cell phones (AOR = 8.20; 95% CI: 4.95, 13.59) and water supply (AOR = 3.37; 95% CI: 1.72, 6.59). Conclusion: This study highlights the need for strengthening both private and public facilities for public–private partnerships to contribute to increased FP use and better health outcomes.
Participation in a Fruit and Vegetable Prescription Program for Pediatric Patients is Positively Associated with Farmers’ Market Shopping
Authors: Saxe-Custack Amy , Sadler Richard , LaChance Jenny , Hanna-Attisha Mona , Ceja Tiffany
Published: June 2020

Objectives: The primary objective was to investigate the association between participation in a farmers’ market fruit and vegetable prescription program (FVPP) for pediatric patients and farmers’ market shopping. Methods: This survey-based cross-sectional study assessed data from a convenience sample of 157 caregivers at an urban pediatric clinic co-located with a farmers’ market. Prescription redemption was restricted to the farmers’ market. Data were examined using chi-square analysis and independent samples t-tests. Results: Approximately 65% of respondents participated in the FVPP. Those who received one or more prescriptions were significantly more likely to shop at the farmers’ market during the previous month when compared to those who never received a prescription (p = 0.005). Conclusions: This is the first study to demonstrate that participation in a FVPP for pediatric patients is positively associated with farmers’ market shopping.
Artificial Neural Network Modeling of Novel Coronavirus (COVID-19) Incidence Rates across the Continental United States
Authors: Mollalo Abolfazl , Rivera Kiara M. , Vahedi Behzad
Published: June 2020

Prediction of the COVID-19 incidence rate is a matter of global importance, particularly in the United States. As of 4 June 2020, more than 1.8 million confirmed cases and over 108 thousand deaths have been reported in this country. Few studies have examined nationwide modeling of COVID-19 incidence in the United States particularly using machine-learning algorithms. Thus, we collected and prepared a database of 57 candidate explanatory variables to examine the performance of multilayer perceptron (MLP) neural network in predicting the cumulative COVID-19 incidence rates across the continental United States. Our results indicated that a single-hidden-layer MLP could explain almost 65% of the correlation with ground truth for the holdout samples. Sensitivity analysis conducted on this model showed that the age-adjusted mortality rates of ischemic heart disease, pancreatic cancer, and leukemia, together with two socioeconomic and environmental factors (median household income and total precipitation), are among the most substantial factors for predicting COVID-19 incidence rates. Moreover, results of the logistic regression model indicated that these variables could explain the presence/absence of the hotspots of disease incidence that were identified by Getis-Ord Gi* (p < 0.05) in a geographic information system environment. The findings may provide useful insights for public health decision makers regarding the influence of potential risk factors associated with the COVID-19 incidence at the county level.
Cost-Effectiveness of Dengue Vaccination in Indonesia: Considering Integrated Programs with Wolbachia-Infected Mosquitos and Health Education
Authors: Suwantika Auliya A. , Kautsar Angga P. , Supadmi Woro , Zakiyah Neily , Abdulah Rizky , Ali Mohammad , Postma Maarten J.
Published: June 2020

Despite the fact that morbidity and mortality rates due to dengue infection in Indonesia are relatively high, a dengue vaccination has not yet been introduced. Next to vaccination, Wolbachia-infected mosquitoes and health education have been considered to be potential interventions to prevent dengue infection in Indonesia. This study was aimed to analyse the cost-effectiveness of dengue vaccination in Indonesia whilst taking Wolbachia and health education programs into account. An age-structured decision tree model was developed to assess the cost-effectiveness. Approximately 4,701,100 children were followed-up in a 10-year time horizon within a 1-year analytical cycle. We compared three vaccination strategies: one focussing on vaccination only, another combining vaccination and a Wolbachia program, and a third scenario combining vaccination and health education. All scenarios were compared with a no-intervention strategy. The result showed that only vaccination would reduce dengue fever (DF), dengue haemorrhagic fever (DHF), and dengue shock syndrome (DSS) by 123,203; 97,140 and 283 cases, respectively. It would save treatment cost at $10.3 million and $6.2 million from the healthcare and payer perspectives, respectively. The combination of vaccination and a Wolbachia program would reduce DF, DHF and DSS by 292,488; 230,541; and 672 cases, respectively. It would also save treatment cost at $24.3 million and $14.6 million from the healthcare and payer perspectives, respectively. The combination of vaccination and health education would reduce DF, DHF, and DSS by 187,986; 148,220; and 432 cases, respectively. It would save treatment cost at $15.6 million and $9.4 million from the healthcare and payer perspectives, respectively. The incremental cost-effectiveness ratios (ICERs) from the healthcare perspective were estimated to be $9995, $4460, and $6399 per quality-adjusted life year (QALY) gained for the respective scenarios. ICERs from the payer perspective were slightly higher. It can be concluded that vaccination combined with a Wolbachia program was confirmed to be the most cost-effective intervention. Dengue infection rate, vaccine efficacy, cost of Wolbachia program, underreporting factor for hospitalization, vaccine price and mortality rate were considered to be the most influential parameters affecting the ICERs.
Microvascular Damage in a Young Female Archer Assessed by Nailfold Videocapillaroscopy: A Case Report
Authors: Sirufo Maria Maddalena , Bassino Enrica Maria , De Pietro Francesca , Ginaldi Lia , De Martinis Massimo
Published: June 2020

Archers are known to be exposed to the risk of developing various injuries, including less described microvascular damages, which can however heavily affect the performance of athletes. Nailfold videocapillaroscopy is a safe, proven and non-invasive method that allows us to examine the nail capillaries and diagnose vascular anomalies in athletes suffering from the consequences of microtrauma caused by repeated use of fingertips. The detection of defined capillaroscopic pictures is the basis for the follow-up and suggests carrying out further clinical investigations to exclude underlying pathologies. In women this aspect is even more important since they are more frequently affected by autoimmune diseases such as scleroderma which can cause microcirculation alterations. We report the case of a 16-year-old woman who has been practicing archery for five years. She had been complaining for two years about painful fingertips, worsening in the last year. Through videocapillaroscopy, carried out by using a ×200 optical probe-equipped videocapillaroscope connected to image analyzer software (VideoCap software 3.0; DS Medica, Milan, Italy), we detected changes in the microvasculature compatible with a non-specific pattern. The findings of these anomalies suggest a diagnostic analysis aimed at excluding the presence of systemic diseases such as scleroderma. Once these conditions are excluded, and assuming that the documented alterations are due to the particular muscular effort and vibrations to which the fingers are subjected in shooting, we suggest follow-up to keep under control possible further developments and clinical changes. As far as we know, this is the first report that documents and describes the condition of microvascular changes in an archer. Archers, similar to other athletes who mainly use fingertips such as volleyball players, are more exposed to the development of digital traumas that can induce alterations in the microcirculation. We suggest that a periodic capillaroscopy should be included in the health surveillance program of these athletes, in fact this simple, reliable, non-invasive and inexpensive diagnostic tool is able to recognize early signs of microvascular damage and then suggest indications for further investigations and or follow-up.
Who Cares for Visiting Nurses? Workplace Violence against Home Visiting Nurses from Public Health Centers in Korea
Authors: Kim Eunjoo , Choi Heeseung , Yoon Ju Young
Published: June 2020

Visiting nurses are commonly exposed to workplace violence, but there is a lack of research on violence against these nurses. The purpose of this study was to identify visiting nurses’ workplace violence experiences during home visits. This study used a mixed method design. Survey data of 357 home visiting nurses from public health centers were collected for the quantitative data, and a focus group interview was conducted with six visiting nurses for the qualitative data. The quantitative data were analyzed using logistic regression, and the qualitative data were analyzed using content analysis. Younger, temporary visiting nurses and those who had previously been exposed to violent clients had a higher risk of workplace violence. The violence visiting nurses faced included not only violence during the visits but also unpredicted danger and harassment after the visit. After experiencing a violent event, visiting nurses’ attitudes and emotions changed toward nursing services. Visiting nurses were likely to deal with violence at the individual level given the insufficient organizational support system. An organizational-level safety management system should be established based on the characteristics of workplace violence risks and the nurses’ experiences in this study.
Nano-Size Biomass Derived from Pomegranate Peel for Enhanced Removal of Cefixime Antibiotic from Aqueous Media: Kinetic, Equilibrium and Thermodynamic Study
Authors: Esmaeili Bidhendi Mehdi , Poursorkh Zahra , Sereshti Hassan , Rashidi Nodeh Hamid , Rezania Shahabaldin , Afzal Kamboh Muhammad
Published: June 2020

Nano-sized activated carbon was prepared from pomegranate peel (PG-AC) via NaOH chemical activation and was fully characterized using BET, FT-IR, FE-SEM, EDX, and XRD. The newly synthesized PG-AC was used for cefixime removal from the aqueous phase. The effective parameters on the adsorption process, including solution pH (2–11), salt effect (0–10%), adsorbent dosage (5–50 mg), contact time (5–300 min), and temperature (25–55 °C) were examined. The experimental adsorption equilibrium was in close agreement with the type IV isotherm model set by the International Union of Pure and Applied Chemistry (IUPAC). The adsorption process was evaluated with isotherm, kinetic, and thermodynamic models and it is were well fitted to the Freundlich isotherm (R2 = 0.992) and pseudo-second-order model (R2 = 0.999). The Langmuir isotherm provided a maximum adsorption capacity of 181.81 mg g−1 for cefixime uptake onto PG-AC after 60 min at pH 4. Hence, the isotherm, kinetic and thermodynamic models were indicated for the multilayer sorption followed by the exothermic physical adsorption mechanism.
Impact of the Burden of COVID-19 in Italy: Results of Disability-Adjusted Life Years (DALYs) and Productivity Loss
Authors: Nurchis Mario Cesare , Pascucci Domenico , Sapienza Martina , Villani Leonardo , D’Ambrosio Floriana , Castrini Francesco , Specchia Maria Lucia , Laurenti Patrizia , Damiani Gianfranco
Published: June 2020

The WHO declared the novel coronavirus disease a pandemic, with severe consequences for health and global economic activity and Italy is one of the hardest hit countries. This study aims to assess the socio-economic burden of COVID-19 pandemic in Italy through the estimation of Disability-Adjusted Life Years (DALYs) and productivity loss. The observational study was based on data from official governmental sources collected since the inception of epidemic until 28 April 2020. DALYs for a disease combines the years of life lost due to premature mortality in the population and the years lost due to disability of the disease. In addition to DALYs, temporary productivity loss due to absenteeism from work and permanent productivity loss due to premature mortality were estimated using the Human Capital Approach. The total DALYs amount to 2.01 per 1000 persons. The total permanent productivity loss was around EUR 300 million while the temporary productivity loss was around EUR 100 million. This evaluation does not consider other economic aspects related to lockdown, quarantine of contacts, healthcare direct costs etc. The burden of disease methodology is functional metric for steering choices of health policy and allowing the government to be accountable for the utilization of resources.
Exploration of Urban Interaction Features Based on the Cyber Information Flow of Migrant Concern: A Case Study of China’s Main Urban Agglomerations
Authors: Li Chun , Duan Xingwu
Published: June 2020

In the context of “space of flow”, urban interaction has become the key force impacting urban landscape evolution and urban sustainable development. Current research on urban interaction analysis is mainly conducted based on the interaction of geographical elements, the virtual flow of information in cyberspace has not been given sufficient attention, particularly the information flows with explicit geographical meaning. Considering the dramatic population migration and the explosive growth of cyberspace in China’s main urban agglomerations, we constructed the information flow of migrant attention (IFMA) index to quantify the urban information interaction derived from public migrant concern in cyberspace. Under the framework coupling spatial pattern analysis and spatial network analysis, exploration spatial data analysis (ESDA) and complex network analysis (CNA) were adopted to identify the urban interaction features depicted by IFMA index in the three main urban agglomerations in China. The results demonstrated that, in the study area: (1) The IFMA index presented a reasonable performance in depicting geographical features of cities; (2) the inconformity between urban role in the network and development positioning confirmed by national planning existed; (3) in the context of New-type urbanization of China, urban interaction feature can be a beneficial reference for urban spatial reconstruction and urban life improvement. Using the cyber information flow with geographical meaning to analyze the urban interaction characteristics can extend the research angle of urban relationship exploration, and provide some suggestion for the adjustment of urban landscape planning.
Physical Activity and Sedentary Behaviour Patterns among Kenyan and Japanese Children: A Comprehensive Cross-Country Comparison
Authors: Kidokoro Tetsuhiro , Fuku Noriyuki , Yanagiya Toshio , Takeshita Tomonari , Takaragawa Mizuki , Annear Michael , Xiaojie Tian , Waiganjo Luka B. , Bogonko Lamec F. , Isika Juliet K. , Kigaru Mbithe D. , Mwangi Francis M.
Published: June 2020

Health benefits of physical activity are well known, yet available physical activity data is limited from children living in African and Asian countries. The purpose of the cross-sectional study was to evaluate and compare physical activity and sedentary behavior patterns, particularly hourly variations, among children in Kenya and Japan. Participants included 298 primary school students (122 Kenyan, 176 Japanese) aged 9–12 years. Physical activity and sedentary behavior were measured with accelerometers. Domain-specific physical activity, screen time, and proportion of children using active transport to school were measured by questionnaire. A two-way ANOVA (countries × time) was used to examine the differences in the activity patterns between Kenyan and Japanese children. The results from the present study demonstrated that Kenyan children spent more time in moderate-to-vigorous physical activity compared to Japanese children (p < 0.05) with the greatest differences found for weekday evenings (for boys and girls) and weekend afternoons (for girls). This suggests that these were ‘critical periods’ to differentiate the physical activity levels between Kenyan and Japanese children. However, a higher proportion of the children from Japan used active transport to school and spent less time in television viewing and computer gaming. The results suggest that both countries have successes and challenges that can aid in developing effective and country-specific intervention strategies for promoting physical activity.
Exploring Advance Directive Perspectives and Associations with Preferences for End-of-Life Life-Sustaining Treatments among Patients with Implantable Cardioverter-Defibrillators
Authors: Kim JinShil , Park Hyung Wook , An Minjeong , Shim Jae Lan
Published: June 2020

Deactivation of an implantable cardioverter-defibrillator (ICD) is a critical issue in the advance care planning (ACP) of ICD recipients; however, related perspectives have rarely been explored. Thus, this study aimed to provide an initial investigation of ICD recipients’ perceived susceptibility and barriers/benefits regarding ACP and/or advance directives (ADs), and associations of these modifiable factors with preferences for end-of-life life-sustaining treatments (LSTs) (cardiopulmonary resuscitation (CPR), ventilator support, hemodialysis, and hospice care). Using a descriptive correlational design, 48 ICD recipients (age, 50.1 years; male, 85.4%) completed survey questionnaires. “No burden on family” was the most highly valued (59.1%), followed by “comfortable death” (20.4%), and both (11.4%). LST preference was 43.8% for ventilator support, 45.8% for both hemodialysis and hospice care, and 54.2% for CPR. Perceived susceptibility to having unexpected end-of-life experiences increased the likelihood of preference for aggressive LSTs, with preferences increasing by 15% for CPR, 17% for ventilator support, and 23% for hemodialysis. A non-modifiable factor, older age, was the only predictor of increased preference for hospice care (odds ratio = 1.09, p = 0.016). Among the modifiable factors, a higher perceived susceptibility increased the likelihood of aggressive LST preferences. The findings imply that to facilitate informed decisions for LSTs, early ACP discussion could be helpful and enhance these modifiable factors.
Exploring the Relationship between Transport Interventions, Mode Choice, and Travel Perception: An Empirical Study in Beijing, China
Authors: Fan Aihua , Chen Xumei
Published: June 2020

Transport interventions help to facilitate the sustainable travel behavior. The effects of transport interventions on travel choices have been addressed extensively. However, little research has been devoted to the influence of transport interventions and travel choice on travel perception. This study aimed to investigate the relationship among the three aspects. Two intervention measures, information intervention and public transport service improvement, were selected. Intervention experiments were designed to collect mode choice and corresponding travel perception in different experiment stages. Process models of information intervention and public transport service improvement were proposed. The results show that information intervention only had a minor effect on mode choice and had no direct effect on travel perception. Public transport service improvement in in-vehicle time and comfort enhanced public transport use dramatically. Comfort improvement also had positive effects on travel perception. Walking had positive and public transport trips had negative effects on travel perception. For travelers who had a high evaluation of car trips, the probability of green mode use would decrease. Travelers who gave high marks to trips by green mode would have a higher probability to keep traveling by green mode. This study contributes to facilitating public transport use and enhancing positive perception during traveling.
Association between Internet Use Behavior and Palpitation among Adolescents: A Cross-Sectional Study of Middle School Children from Northwest Romania
Authors: Lazea Cecilia , Popa Alexandra , Varga Cristina
Published: June 2020

Purpose: The use of the internet is a tool and media literacy has become an essential skill among adolescents. Related to this behavior, some adolescents evoke cardiovascular effects. The purpose of this study was to explore a possible correlation between internet use behavior and occurrence of palpitations and related symptoms among a representative cohort of adolescents from the north-west region of Romania. Method: The study included students of seven middle schools from Northwest Romania. Participants completed an anonymous questionnaire consisting of 18 questions about internet use. Results: In total, 1147 students responded to the study. Mean duration of daily internet usage was 2.57 h during school time and 3.57 h during the holidays. A total of 77% of adolescents had more than one symptom related to internet use, and 11% of them reported palpitations and related symptoms. We found an independent relation between palpitation and urban background, palpitations and the internet usage time interval 20:00–24:00, and palpitations and tobacco smoking. Strong heartbeats were independently associated with the time interval 12:00–16:00, tobacco smoking, and energy drink consumption. Conclusion: In our cohort, the most important factors associated with the occurrence of palpitations and related symptoms were the timeframe of internet usage and smoking.
Systematic Review of Clinical Insights into Novel Coronavirus (CoVID-19) Pandemic: Persisting Challenges in U.S. Rural Population
Authors: Lakhani Hari Vishal , Pillai Sneha S. , Zehra Mishghan , Sharma Ishita , Sodhi Komal
Published: June 2020

(1) Introduction. A recent viral outbreak of novel coronavirus (CoVID-19) was declared as a pandemic by the World Health Organization (WHO) due to its global public health concern. There has been an aggressive growth in the number of emerging cases suggesting rapid spread of the virus. Since the first reported case of CoVID-19, there has been vast progress in understanding the dynamics of CoVID-19. However, there is an increasing evidence of epidemiological disparity in disease burden between urban and rural areas, with rural areas having minimal pandemic preparedness and their own healthcare challenges. Therefore, this review aims to provide insight on the pathogenesis and the transmission dynamics of CoVID-19 along with pharmacological and non-pharmacological intervention strategies to mitigate the clinical manifestation of this virus. This review also aims to assess existing challenges of the CoVID-19 pandemic in rural areas based on past pandemic experiences and the effect on rural population. (2) Methods. A literature review was conducted using databases such as PubMed, Science Direct, Academic Search Premier, ProQuest, and Google Scholar, along with information from governmental organizations such as Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO). (3) Results. The causative virus, with its likely zoonotic origin, has demonstrated high pathogenicity in humans through increasing human-to-human transmission leading to extensive mitigation strategies, including patient quarantine and mass “social distancing” measures. Although the clinical manifestation of symptoms is mild in majority of the virus-inflicted population, critical patients may present with pneumonia and acute respiratory distress syndrome, exacerbated by pre-existing comorbidities, eventually leading to death. While effective coronavirus disease (CoVID-19)-specific vaccines and drugs are under clinical trials, several pharmacological and non-pharmacological interventions have been adapted to manage symptoms and curtail the effect of the virus to prevent increasing morbidity and mortality. Several persisting challenges have been noted for mitigating CoVID-19 in rural areas, including the poor healthcare infrastructure, health literacy, pandemic preparedness along with the fact that majority of rural population are frail subjects with pre-existing comorbidities. (4) Discussion. The increasing rate of incidence of CoVID-19 presents its own challenges, burdening healthcare institutions and the global economy, and impacting the physical and mental health of people worldwide. Given the clinical insights into CoVID-19 and the challenges presented in this review for the U.S. rural population, mitigation strategies should be designed accordingly to minimize the morbidity and mortality of this contagion.
The Ubiquitin-Proteasome System Does Not Regulate the Degradation of Porcine β-Microseminoprotein during Sperm Capacitation
Authors: Tumova Lucie , Zigo Michal , Sutovsky Peter , Sedmikova Marketa , Postlerova Pavla
Published: June 2020

Sperm capacitation, one of the key events during successful fertilization, is associated with extensive structural and functional sperm remodeling, beginning with the modification of protein composition within the sperm plasma membrane. The ubiquitin-proteasome system (UPS), a multiprotein complex responsible for protein degradation and turnover, participates in capacitation events. Previous studies showed that capacitation-induced shedding of the seminal plasma proteins such as SPINK2, AQN1, and DQH from the sperm surface is regulated by UPS. Alterations in the sperm surface protein composition also relate to the porcine β-microseminoprotein (MSMB/PSP94), seminal plasma protein known as immunoglobulin-binding factor, and motility inhibitor. MSMB was detected in the acrosomal region as well as the flagellum of ejaculated boar spermatozoa, while the signal disappeared from the acrosomal region after in vitro capacitation (IVC). The involvement of UPS in the MSMB degradation during sperm IVC was studied using proteasomal interference and ubiquitin-activating enzyme (E1) inhibiting conditions by image-based flow cytometry and Western blot detection. Our results showed no accumulation of porcine MSMB either under proteasomal inhibition or under E1 inhibiting conditions. In addition, the immunoprecipitation study did not detect any ubiquitination of sperm MSMB nor was MSMB detected in the affinity-purified fraction containing ubiquitinated sperm proteins. Based on our results, we conclude that UPS does not appear to be the regulatory mechanism in the case of MSMB and opening new questions for further studies. Thus, the capacitation-induced processing of seminal plasma proteins on the sperm surface may be more complex than previously thought, employing multiple proteolytic systems in a non-redundant manner.
Ibrutinib in Gynecological Malignancies and Breast Cancer: A Systematic Review
Authors: Metzler Julian Matthias , Burla Laurin , Fink Daniel , Imesch Patrick
Published: June 2020

Ibrutinib is an orally available, small-molecule tyrosine kinase inhibitor. Its main purpose is to inhibit Bruton’s tyrosine kinase (BTK), an enzyme that is crucial in B cell development. It is FDA approved for the treatment of certain hematological malignancies. Several promising off-target drug effects have led to multiple, mostly preclinical investigations regarding its use in solid tumors. Unfortunately, data on its effectiveness in gynecological malignancies are limited, and (systematic) reviews are missing. The objective of this review was to summarize the existing literature and to analyze the evidence of ibrutinib as a treatment option in gynecological malignancies, including breast cancer. Studies were identified in MEDLINE and EMBASE using a defined search strategy, and preclinical or clinical research projects investigating ibrutinib in connection with these malignancies were considered eligible for inclusion. Our findings showed that preclinical studies generally confirm ibrutinib’s efficacy in cell lines and animal models of ovarian, breast, and endometrial cancer. Ibrutinib exerts multiple antineoplastic effects, such as on-target BTK inhibition, off-target kinase inhibition, and immunomodulation by interference with myeloid-derived suppressor cells (MDSCs), programmed death-ligand 1 (PD-L1), and T cell response. These mechanisms were elaborated and discussed in the context of the evidence available. Further research is needed in order to transfer the preclinical results to a broader clinical appliance.
Quantitative Trait Locus Mapping of Clubroot Resistance and Plasmodiophora brassicae Pathotype Banglim-Specific Marker Development in Brassica rapa
Authors: Choi Su Ryun , Oh Sang Heon , Chhapekar Sushil Satish , Dhandapani Vignesh , Lee Chang Yeol , Rameneni Jana Jeevan , Ma Yinbo , Choi Gyung Ja , Lee Soo-Seong , Lim Yong Pyo
Published: June 2020

Clubroot resistance is an economically important trait in Brassicaceae crops. Although many quantitative trait loci (QTLs) for clubroot resistance have been identified in Brassica, disease-related damage continues to occur owing to differences in host variety and constant pathogen variation. Here, we investigated the inheritance of clubroot resistance in a double haploid population developed by crossing clubroot resistant and susceptible lines “09CR500” and “09CR501”, respectively. The resistance of “09CR500” to Plasmodiophora brassicae pathotype “Banglim” was controlled as a single dominant gene, with the segregation of resistance and susceptibility being nearly 1:1. PbBrA08Banglim was identified as having a logarithm of odds value of 7.9–74.8, and a phenotypic variance of 26.0–97.1% with flanking marker “09CR.11390652” in A08. After aligning QTL regions to the B. rapa reference genome, 11 genes were selected as candidates. PbBrA08Banglim was located near Crr1, CRs, and Rcr9 loci, but differences were validated by marker analysis, gene structural variations, and gene expression levels, as well as phenotypic responses to the pathotype. Genotyping using the “09CR.11390652” marker accurately distinguished the Banglim-resistance phenotypes in the double haploid population. Thus, the developed marker will be useful in Brassica breeding programs, marker-assisted selection, and gene pyramiding to identify and develop resistant cultivars.