bluuebunny/crossref_metadata_2025 huggingface dataset:
The Good, the Bad and the Ugly: Practices and Perspectives on Hardware Acceleration for Embedded Image Processing
Authors: Fryer Joshua , Garcia Paulo
Published: December 2022

Modern embedded image processing deployment systems are heterogeneous combinations of general-purpose and specialized processors, custom ASIC accelerators and bespoke hardware accelerators. This paper offers a primer on hardware acceleration of image processing, focusing on embedded, real-time applications. We then survey the landscape of High Level Synthesis technologies that are amenable to the domain, and present our ongoing work on IMP-Lang, a language for early stage design of heterogeneous image processing systems.
We show that hardware acceleration is not just a process of converting a piece of computation into an equivalent hardware system: that naive approach offers, in most cases, little benefit. Instead, acceleration must take into account how data is streamed throughout the system, and optimize that streaming accordingly. We show that the choice of tooling plays an important role in the results of acceleration. Different tools, in function of the underlying language paradigm, produce wildly different results across performance, size, and power consumption metrics. Finally, we show that
bringing heterogeneous considerations to the language level offers significant advantages to early design estimation, allowing designers to partition their algorithms more efficiently, iterating towards a convergent design that can then be implemented across heterogeneous elements accordingly.
Trend, spatial distribution and predictors of childhood acute respiratory infection in Ethiopia: Evidence from Ethiopia’s 2005, 2011, and 2016 demographic and health survey
Authors: Tesfaye Solomon Hailemariam , Seboka Binyam Tariku , Sisay Daniel
Published: December 2022

Background In Ethiopia, acute respiratory infections (ARIs) are a leading cause of morbidity and mortality among children under five years. Geographically linked data analysis using nationally representative data is crucial to map distribution of ARIs and identify high risk areas. Therefore, this study aimed to investigate trend, spatial distribution and identify spatial predictors of ARI in Ethiopia. Methods Secondary data from the Ethiopian Demographic Health Survey (EDHS) of 2005, 2011, and 2016 were used. Kuldorff’s spatial scan statistic using the Bernoulli model was used to identify spatial clusters with high or low ARI. Ordinary Kriging was used to interpolate ARI. Hot spot analysis was conducted usingGetis-OrdGistatistics. Eigenvector spatial filtering regression model was carried out to identify spatial predictors of ARI. Results The prevalence of ARI decreased from 12.6% (95%, CI: 0.113–0.138) in 2005 to 6.6% (95% CI: 0.055–0.077) in 2016. Across the three surveys, clusters with a high prevalence of ARI were observed in the North part of Ethiopia. The spatial regression analysis revealed that the spatial variation of ARI was significantly associated with using biomass fuel for cooking and children not initiating breastfed within 1-hour of birth. This correlation is strong in the Northern and some areas in the Western part of the country. Conclusion Overall there has been a considerable decrease in ARI, but this decline in ARI varied in some regions and districts between surveys. Biomass fuel and early initiation of breastfeeding were independent predictors of ARI. There is a need to prioritize children living in regions and districts with high ARI.
HIV Status Knowledge and Healthcare Utilization in Rural South Africa: An illustrative comparison of HIV and Diabetes in the HAALSI Cohort
Authors: Beidelman Erika , Bärnighausen Till , Wing Coady , Tollman Stephen , Phillips Meredith , Rosenberg Molly
Published: December 2022

Background
Studies from rural South Africa indicate that people living with HIV (PLHIV) may have better health outcomes than those without, potentially due to the frequent healthcare visits necessitated by infection. Here, we examined the association between HIV status and healthcare utilization, using diabetes as an illustrative comparator of another high-burden, healthcare-intensive disease.
Methods
Our exposure of interest was awareness of positive disease status for both HIV and diabetes. We identified 742 individuals who were HIV-positive and aware of their status and 305 who had diabetes and were aware of their status. Further, HIV status was divided into two groups based on viral suppression. For each disease, we estimated the association with (1) other comorbid, chronic conditions, (2) health facility visits, (3) household-level healthcare expenditure, and (4) per-visit healthcare expenditure. We used log-binomial regression models to estimate prevalence ratios for co-morbid chronic conditions. Linear regression models were used for all other outcomes.
Results
Virally suppressed PLHIV had decreased prevalence of chronic conditions, increased public clinic visits [β = 0.59, 95% CI: 0.5, 0.7], and reduced per-visit private clinic spending [β = -60, 95% CI: -83, -6] compared to those without HIV. No differences were observed in hospitalizations and per-visit spending at hospitals and public clinics between virally suppressed PLHIV and non-PLHIV. Conversely, diabetic individuals had increased prevalence of chronic conditions, increased visits across facility types, increased household-level expenditures (β = 88 R, 95% CI: 29, 154), per-visit hospital spending (β = 54 R, 95% CI: 7, 155), and per-visit public clinic spending (β = 31 R, 95% CI: 2, 74) compared to those without diabetes.
Conclusions
Our results suggest that older PLHIV are visiting public clinics more often than their HIV-negative counterparts but are spending similarly on a per-visit basis. This provides evidence that the positive health outcomes observed among PLHIV may be explained by different healthcare engagement patterns. Through our illustrative comparison between PLHIV and diabetic individuals, we provide evidence that shifting disease burdens towards chronic and historically underfunded diseases, like diabetes, may be changing the landscape of health expenditure inequities.
Knowledge and Barriers to a Healthy Lifestyle in Medical Students
Authors: Nelson Brittany , Petushek Erich , Teising Sarah
Published: December 2022

Background
Across the US, chronic illnesses, including cancer and cardiovascular disease, largely result from poor lifestyle decisions such as diet, tobacco/alcohol use, and physical inactivity. Medical students, in particular, have exceedingly unhealthy lifestyle habits, which can result in severe medical conditions, future poor patient outcomes, and burnout. However, little evidence exists on what perceived barriers medical students hold on lifestyle behaviors or how well they understand the relationship between specific lifestyle behaviors and their impact on health.
Method
This study included data from a self-selected sample of 127 medical students aged 22–41 years. All participants were from a midwestern university. Measures included the perceived health impact of 14 different lifestyle and dietary behaviors, self-reported barriers to lifestyle behaviors, and basic demographic questions.
Results
Results showed an average correlation of − .004 between participants' perceived impact and the actual impact of the behaviors on health (SD = .25; CI = − .047 − .039). Results also identified perceived barriers across behaviors that impact health. For example, results showed the most commonly reported barriers across eating behaviors are cost at 17%, taste at 14%, time at 8%, and food spoiling too quickly at 7%.
Conclusion
Data suggests medical students have insufficient knowledge of the impact of lifestyle behaviors on health. Results also identified several perceived challenges for each lifestyle behavior. Interventions that target a medical student population should include information regarding how to overcome perceived barriers and the impact of lifestyle behaviors on health. Incorporating such information will bolster future interventions' effectiveness.
CD34+ synovial fibroblasts exhibit high osteogenic potential in synovial chondromatosis
Authors: Li Xiaoyu , Sun Hao , Li Hao , Li Deng , Cai Zhiqing , Xu Jie , Ma Ruofan
Published: December 2022

Backgroud Synovial chondromatosis (SC) is a disorder of the synovium characterized by the formation of cartilaginous nodules within the synovium. The aim of this study was to identify the abnormally differentiated progenitor cells and possible pathogenic signaling pathways. Methods Loose bodies and synovium were obtained from patients with SC during knee arthroplasty. Single cell RNA sequencing was used to identify cell subsets and their gene signatures in SC synovium. Cells derived from osteoarthritis (OA) synovium were used as control. Multi-differentiation and colony-forming assays were used to identify progenitor cells. Roles of transcription factors and signaling pathways were investigated through computational analysis and experimental verification. Results We identified changes in the proportions of CD34 + sublining fibroblasts in SC synovium. CD34 + CD31- cells and CD34-CD31- cells were sorted from SC synovium. Compared with CD34- cells, CD34 + cells had larger alkaline phosphatase (ALP)-stained area and calcified area after osteogenic induction. In addition, CD34 + cells exhibited a stronger tube formation ability than CD34-cells. Our bioinformatic analysis suggested the expression of TWIST1 suppressed the osteogenic potential of CD34- sublining fibroblasts and was regulated by TGF-β signaling pathway. Experiment showed that the combination of TGF-β1 and harmine, an inhibitor of TWIST1, could further stimulate the osteogenesis of CD34 + cells. Conclusions Overall, CD34 + stromal cells in SC synovium have multiple differentiation potentials, especially osteogenic differentiation potential, which may be responsible for the pathogenesis of SC.
Electroacupuncture ameliorates neuronal injury by NLRP3/ASC/Caspase-1 mediated pyroptosis in cerebral ischemia-reperfusion
Authors: wang Huanyuan , Xu Xifa , Du Guangzhong , Li Yan
Published: December 2022

NLRP3/ASC/Caspase-1 mediated pyroptosis is one of the important causes of cerebral ischemia-reperfusion (I/R) injury. Electroacupuncture (EA) is widely used in clinical treatment of ischemic stroke. However, mechanism of EA on ischemic stroke remains unclear. Therefore, on basis of previous work, this study used middle cerebral artery occlusion (MCAO) 2h and then reperfusion 7d in rats to simulate brain I/R process. EA with Bahui (GV20) and Zusanli (ST36) and VX-765 (a specific inhibitor of Caspase-1) were performed. In this study, we found that EA improved cerebral infarct size and neuronal damage, including ultrastructural injury, and ameliorated nitro/oxidative stress in cerebral I/R. Additionally, EA treatment significantly decreased ASC, Caspase-1, GSDMD and IL-1β expression and VX-765 treatment significantly decreased NLRP3, Caspase-1 and IL-1β expression. This proved that EA can regulate NLRP3/ASC/Caspase-1 mediated pyroptosis, improve neuronal injury during cerebral I/R and provide basic experimental data for clinical treatment.
Successful Oxaliplatin Desensitization After Omalizumab Administration
Authors: KATRAN ZEYNEP YEGİN , Bulut İsmet
Published: December 2022

Background: In our patient, who was diagnosed with metastatic colorectal cancer, who received a chemotherapy regimen containing oxaliplatin; We present successful desensitization after omaizumab in addition to our premedication scheme
Case presentation: 39 years,F. She underwent hemicolectomy and liver metastasectomy with the diagnosis of metastatic colon adenocarcinoma. Chemotherapy regimen consisting of 5 florauracil + Bevacizumab + Oxaliplatin was started. After completing infusions of 5 florauracil while she was receiving her fourth chemotherapy; In the 20th minute of the oxaliplatin infusion, redness and itching began in the palms. While her whole body was red,she had abdominal pain, low back pain, she had no other systemic findings. His blood pressure was 90/60 mmHg. With premedication, oxaliplatin was given in 12 dilutions of 3 bottles with the M.Castel scheme. In the 11th step, at the 5th minute, redness and itching developed on the face and palms. She stated that she had chest and abdominal pain with hypotansıon. After the current condition was treated, 92 mg of oxaliplatin could be given while the target dose was 120 mg . , a single dose of omalizumab 150 mg sc was administered the day before. Standard premedication was also given. The infusion was prepared as 4 bottles of 16 steps. The first three bottles were completed without any problems. Based on her previous reaction, additional premedication was given after Step 14.The desensitization scheme was successfully completed by taking the target dose of 120 mg in total.
Conclusıons: We were able to reach the target oxaliplatin dose successfully after our omalizumab administration an additional day before. Although more studies are needed on this subject, we think that omalizumab can be added to the standard premedication schemes of clinics in high-risk patients.
Two New Cobalt(II) Heterotrispin Dimers Bridged by Functional Nitronyl Nitroxides: Structure and Magnetic Properties
Authors: Ma Jin-Ke , Chen Jing , Zhang You-Juan , Wang Qing-Lun
Published: December 2022

Two cyclic dimer Co(II)-nitronyl nitroxide (NITR) complexes, [Co(hfac)2(NITmPh3Py)]2 (1) and [Co(hfac)2(NIToPh3Py)]2 (2) (NITmPh3Py = 2-[3-methoxyphenyl(3-pyridinyl)]-4,4,5,5-tetramethyl
imidazoline−1-oxyl-3-oxide; NIToPy3Ph =2-[2-methoxyphenyl(3-pyridinyl)]-4,4,5,5-tetramethyl
imidazoline−1-oxyl-3-oxide; hfac = hexaflfluoroacetylacetonate) have been successfully synthesized and characterized structurally and magnetically. Complex 1 crystallizes in the orthorhombi space group Pbcn with Z = 4, while complex 2 is in monoclinic space group P21/c with Z =2. The magnetic susceptibility studies show strong antiferromagnetic interactions between Co(II) ion and NITR radical in complexes 1 and 2.
Investigation of the optimal indocyanine green dose in real‐time fluorescent cholangiography during laparoscopic cholecystectomy with an ultra-high definition 4K fluorescent system: a randomized controlled trial
Authors: Liu Hui , Kuang Jiao , Huang Yu , Xu Yujie , Li Tianyang , Li Peilin , Huang Zisheng , Zhang Shuai , Weng Jiefeng , Lai Yueyuan , Wu Zhaofeng , Lin Fan , Gu Weili
Published: December 2022

Aims: This study aimed to investigate the indocyanine green (ICG) dose in real‐time fluorescent cholangiography during laparoscopic cholecystectomy (LC) with a 4K fluorescent system.
Methods: A randomized controlled clinical trial was conducted in patients who underwent LC for treatment of cholelithiasis. Using the OptoMedic 4K fluorescent endoscopic system, we compared four different doses of ICG (1, 10, 25, and 100 µg) administered intravenously within 30 min preoperatively and evaluated the fluorescence intensity (FI) of the common bile duct and liver background and the bile-to-liver ratio (BLR) of the FI at three timepoints: before surgical dissection of the cystohepatic triangle, before clipping the cystic duct, and before closure.
Results: Forty patients were randomized into four groups, and 33 patients were fully analyzed, with 10 patients in Group A (1 µg), 7 patients in Group B (10 µg), 9 patients in Group C (25 µg), and 7 patients in Group D (100 µg). The preoperative baseline characteristics were compared among groups (p > 0.05). Group A showed no or minimal FI in the bile duct and liver background, while Group D showed extremely high FIs in the bile duct and in the liver background at the three timepoints. Groups B and C presented with visible FI in the bile duct and low FI in the liver background. With increasing ICG doses, the FIs in the liver background and bile duct gradually increased at the three timepoints. The BLR, however, showed no increasing trend with an increasing ICG dose. A relatively high BLR on average was found in Group B, without a significant difference compared to the other groups (p > 0.05).
Conclusion: An ICG dose ranging from 10 µg to 25 µg by intravenous administration within 30 min preoperatively was appropriate for real‐time fluorescent cholangiography in LC with a 4K fluorescent system.
Registration: This study was registered in the Chinese Clinical Trial Registry (ChiCTR No: ChiCTR2200064726)
Design, synthesis, and biological evaluation of new 2-(4-(methylsulfonyl)phenyl)-N-phenylimidazo[1,2-a]pyridin-3-amine as selective COX-2 inhibitors
Authors: Movahed Mahsa Azami , Abbasi Fatemeh Khadem , Rajabi Mahsa , Abedi Niusha , Naderi Nima , Daraei Bahram , Zarghi Afshin -
Published: December 2022

Cyclooxygenase (COX), which plays a role in converting arachidonic acid to inflammatory mediators, could be inhibited by non-steroidal anti-inflammatory drugs (NSAIDs). Although potent NSAIDs are available for the treatment of pain, fever, and inflammation, some side effects such as gastrointestinal ulcers limit the use of these medications. During recent years, selective COX-2 inhibitors with a lower incidence of adverse effects attained an important position in medicinal chemistry. In order to introduce some new potent COX-2 inhibitors, a new series of 2-(4-(methylsulfonyl)phenyl)-N-phenylimidazo[1,2-a]pyridin-3-amines was designed, synthesized, and evaluated. The designed compounds were synthesized through multistep reactions. Enzyme inhibition assay and formalin test were performed to evaluate the activity of these compounds. The docking studies demonstrated SO2Me pharmacophore was inserted into the secondary pocket of COX-2, and other parts of docked molecules were positioned as well as a crystallographic ligand in the COX-2 active site. Among these compounds, 8-methyl-2-(4-(methylsulfonyl)phenyl)-N-(p-tolyl)imidazo[1,2-a]pyridin-3-amine (5n) exhibited the most potency and selectivity against COX-2 (IC50= 0.07 µM, SI= 508.6). The antinociceptive activity assessment via the formalin test showed that nine derivatives (5a, 5d, 5h, 5i, 5k, 5q, 5r, 5s, and 5t) possessed significant activity compared with the control group with a p-value less than 0.05.
Effect of organic zinc on production performances, meat performances, apparent nutrients digestibility and gut microbiota of broilers in low protein diets
Authors: Dong Liping , Li Yumei , Zhang Yonghong , Zhang Yan , Ren Jing , Zheng Jinlei , Diao Jizhe , Ni Hongyu , Yin Yijing , Sun Ruihong , Liang Fangfang , Li Peng , Zhou Changhai , Yang Yuwei
Published: December 2022

The high cost of feed and nitrogen pollution caused by high protein diets, which have become major challenges restricting sustainable development in China’s animal husbandry. Properly reducing the protein level and improving protein utilization in feed are a promising approach in solving this problem. To determine the optimal dose of methionine hydroxyl analog chelated zinc (MHA-Zn) in reduced 1.5% protein diets of broilers, total 216 1-day-old broilers were randomly allotted into 4 treatments and assess the index of growth and development at 42-days. Results showed no significant difference was observed for edible part between low protein (LP) diet group (90 mg/kg MHA-Zn) and normal diet group (P > 0.05), and adding 90 mg/kg MHA-Zn in LP diet significantly improved ileum morphology and apparent total tract digestibility (ATTD) of nutrients (P < 0.01; P < 0.05). A 16S rRNA sequencing analysis indicated that supplementing LP diet with 90 mg/kg MHA-Zn was adequate for production performance of broilers, it can promote beneficial bacteria of cecum (Lactobacillus, Butyricoccus, Oscillospira et al.) (P < 0.01). These findings will be useful for guiding organic Zn concentration optimization in LP of broilers to improve production performance through restoring the imbalance of intestinal microbiome under the premise of reducing environmental pollution.
Open Source Board Based Acoustofluidic Transwells for Reversible Disruption of the Blood-Brain Barrier for Therapeutic Delivery
Authors: Wang Ke , Sun Chao , Duciums Povilas , Zhang Hongxiong , Wu Zhenlin , Tian Liangfei , Peng Wang , Fu Yongqing , Wei Jun , Cai Meng , Zhong Yi , Li Xiaoyu , Yang Xin , Cui Min
Published: December 2022

Background
Blood-brain barrier (BBB) is a crucial but dynamic structure that functions as a gatekeeper for the central nervous system (CNS). Managing sufficient substances across the BBB is a major challenge, especially in the development of therapeutics for CNS disorders.
Methods
To achieve an efficient, fast and safe strategy for BBB opening, an acoustofluidic transwell (AFT) was developed for reversible disruption of the BBB. The proposed AFT was consisted of a transwell insert where the BBB model was established, and a surface acoustic wave (SAW) transducer realized using open-source electronics based on printed circuit board techniques.
Results
In the AFT device, the SAW produced acousto-mechanical stimulations to the BBB model resulting in decreased transendothelial electrical resistance in a dose dependent manner, indicating the disruption of the BBB. Moreover, SAW stimulation enhanced transendothelial permeability to sodium fluorescein and FITC-dextran with various molecular weight in the AFT device. Further study indicated BBB opening was attributed to the apparent stretching of intercellular spaces. An in vivo study using a zebrafish model demonstrated SAW exposure promoted penetration of sodium fluorescein to the CNS.
Conclusions
In summary, AFT effectively disrupts the BBB under the SAW stimulation, which is promising as a new drug delivery methodology for neurodegenerative diseases.
Optimization of extraction of gingerol and studies on drying kinetics of ginger using Box-Behnken design
Authors: Sakkaravarthy Abishek , Prabhakaran Bhavadharani , Gurumoorthi Gurumoorthi Parameswaran
Published: December 2022

The present study is attempted to perform the drying characteristics of ginger using a differential drying method and develop an optimization of the effect on various parameters such as moisture content, rehydration ratio, and to extract bio active compounds viz., total gingerol content, and total shogoal content followed by factors of Time (60–300 min), Temperature (70–160°C) and slice thickness (2–6 mm), respectively. The Box-Behnken Design (BBD) was selected for the design and optimization of the process variables. The result showed a significant effect on responses. The second-order polynomial models were constructed using experimental data to produce response surfaces and contour plots. The optimal conditions were determined by fitting an experimental model to correlate with the independent variables and responses. The drying temperature was discovered to be the most influential factor in all of the responses studied. Using response surfaces and desirability functions, the ideal process parameters are compared to the actual values respectively. To sum up, the optimal conditions obtained at the maximum responses as MC, RR, TGC, and TSC were 87.85% (w/w), 2.875% (w/w), 22.5 g/100g and 3.3 g/100g under the consideration of factors such as time, temperature, and slice thickness of 180 min, 160°C and 2mm.
Blackgold: Cow Dung Turns to Agricultural Treasure by Swift Composting
Authors: Choubey Poonam , Tiwari Yogesh Kumar
Published: December 2022

World has a long history of using Cow dung; bovine animals excreta, as crop nutritional resource in different ways. Cow dung is a source of diverse group of microorganisms that are beneficial to plants and humans as well due to their ability to produce a wide range of metabolites. Several cow dung microorganisms exhibit proven ability to enhance soil health and fertility. This research explained the swift composting methods of cow dung with minimum or no loss to its microbial composition. The process involves inoculation of the cow dung with some microbial inoculants. A combination of pit and heap methods was used in this experiment. The methods applied fastened the composting process and decomposed cow dung within 30 days. Additional enrichment with bio-capsules loaded with concentrated bio-fertilizers has proven an increasement in nutritional value of the cow dung compost. Present research also supported superiority of pit method of composting over heap methods. The research will support farmers and the farmyard manure producers to covert their animal excreta in high nutritional compost which further will enhance soil health and will also help in achieving economic growth. The process will also help municipal corporations in decomposing animal excreta in compost with enhanced potential.
Prediction model optimization, simulation, and experimental verification based on the material characteristic and dynamic angle on thrust force and torque in drilling GJV450
Authors: Geng Wenfeng , Lv Dejin , Yu Xin , Wang Yongguo
Published: December 2022

Compact graphite cast iron (CGI) is utilized extensively in the production of vehicle engines because it has numerous thermo-mechanical benefits. The main issues with CGI drilling are typically tied to changes in material properties, strong drilling forces, and limited tool lives. As a result, it is important to comprehend and anticipate the thrust forces and torques produced during CGI drilling. In this study, a prediction model for GJV450, a kind of CGI, is given that considers both the thermal softening of the material and the dynamic changes in the tool operating angle during the machining process. It is based on an optimized constitutive model. Finally, a three-dimensional finite element model is optimized utilizing the new constitutive model to simulate the drilling process of GJV450. Comparisons between the experimentally observed thrust forces, torques, and chip morphology are made with the results of simulations and predictions. The results show that the projected results are more in line with the experimental results than the models used by commercial FE software and that the thrust force error is reduced by 5.5% and the torque error is decreased by 19.13%.
Implementation stages for integrating behavioral health and primary care: A participatory Delphi study to refine a determinant framework
Authors: Domlyn Ariel M , Wandersman Abraham , Palinkas Lawrence A , Zarrett Nicole , Weist Mark D
Published: December 2022

Background: The integration of behavioral health and primary care is a best practice to improve patient outcomes and achieve health equity. However, the process of integrating is complex, requiring organizational change and sometimes a complete system overhaul. Implementation science offers useful ideas for helping healthcare organizations to implement effective care, including recognition that change occurs incrementally and is stymied by specific barriers and facilitators. Although determinants (i.e., barriers and facilitators) of successful care integration have been identified their relevance to organizations seeking to integrate care remains unknown. This study sought to understand which implementation determinants (defined by the R=MC2 framework, where Readiness is conceptualized as Motivation, Innovation-specific Capacity, and General Capacity) are most important in the process of integrating care across four implementation stages: Exploration, Installation, Initial Implementation, and Full Implementation.
Methods: A participatory Delphi study design was used to gather practice-based evidence from ten integrated care practitioners, researchers, and technical assistance providers. Qualitative and quantitative data were collected across four rounds. Qualitative summaries were presented back to participants between rounds for reaction and recalibration. The Framework Method guided initial qualitative analyses, which were then triangulated with descriptive statistics from a process survey. Coders used fuzzy set theory to create the final results on perceived relevance of each determinant across stages of implementation.
Results: Determinants most relevant across implementation stages are Leadership, Priority, a Champion, Supportive Climate, Culture, Innovativeness, and Staff Capacities. Determinant strength is most critical during active implementation stages.
Conclusions: The present study is one of only a few that apply implementation science frameworks to the integration of behavioral health and primary care. Results provide a structure for assessing determinants by phase and could be used to determine precision and timing of resource allocation to facilitate integration.
Synthesis of Activated Carbon Composited With Egyptian Black Sand for Enhanced Adsorption Performance toward Methylene Blue Dye
Authors: Elkholy Ahmed Salah , Yahia Mohamed Saber , Elnwawy Mohamed Abdelsamei , Gomaa Hosny Anwar , Elzaref Ahmed Shafek
Published: December 2022

The present study reports the feasibility of the synthesis of a novel porous activated carbon (OS400) composite adsorbent prepared from olive stone and impregnated with garnet (GA) types of black sand minerals. The Activated Carbon/ garnet composite (OSMG) was applied for the sorption of macromolecular organic dye. The structural characteristics of the synthesized composite were evaluated by Brunauer–Emmett–Teller (BET), N2 adsorption/desorption measurements, Scanning Electron Microscopy equipped with Energy Dispersive X-ray spectroscopy (SEM-EDX), X-ray diffraction (XRD), and a Fourier transform infrared spectrometer (FT-IR). The specific surface area of (GA), (OS400), and (OSMG) were 5.157 m2.g− 1, 1489.598 m2.g− 1, and 546.392 m2.g− 1, respectively. The high specific surface area and effective active centers of the new composite promoted the adsorption of methylene blue (MB). The experiments were carried out under various conditions such as contact time, initial concentration of adsorbate, adsorbent dosage, pH, and temperatures. The equilibrium adsorption data were evaluated using the Langmuir and Freundlich isotherm models. The results display that, the adsorption isotherm had an excellent fitting to the Freundlich model. Furthermore, the data obtained from adsorption kinetic models showed that the pseudo-second-order model more agreeing for describing the (MB) adsorption reaction, suggesting a chemisorption mechanism. The values of thermodynamic parameters indicate that methylene blue dye adsorption onto the (GA) adsorbents through an endothermic reaction, while exothermic sorption of MB onto (OS400) and (OSMG), with a non-spontaneous process.
Structural analysis, in vitro antioxidant and lipid-lowering activities of purified Tremella fuciformis polysaccharide fractions
Authors: Li Xige , Zhang Fengyi , Jiang Chaoxian , Jiang Jun , Hou Yanhui
Published: December 2022

In order to study the composition, structure and physicochemical properties of Tremella fuciformis polysaccharide (TFPS), four new polysaccharide fractions (TFPS1, TFPS2, TFPS3 and TFPS4) were successfully isolated from the hot-water extracted crude polysaccharides by DEAE-52 cellulose column. Their structures were analyzed by FT-IR, SEM, HPGPC, monosaccharide composition, Congo red and I2-KI experiments. TFPS1 was a heteropolysaccharide with a molecular weight of 742 Da for the major polysaccharide fragment. TFPS2, TFPS3 and TFPS4 were single component homogeneous polysaccharides with 350774 Da, 622675 Da and 624724 Da, respectively. Glucose was the major monosaccharide of TFPS1 and TFPS2, while Mannose was the major monosaccharide of TFPS3 and TFPS4. TFPS1 and TFPS2 displayed a stable triple helix structure at aqueous solution, while TFPS3 and TFPS4 presented longer side chains and more branched chains. TFPS1, TFPS2, TFPS3 and TFPS4 all possessed in vitro antioxidant activities. Moreover, the four polysaccharide fractions all demonstrated significant cholesterol binding ability, as well as obvious sodium taurocholate binding ability. The results of this study may provide some guidance on the medicinal value of TFPS.
Assessing the protection of Key Biodiversity Areas in mountains at conservation-relevant scales
Authors: Ly Amina , Geschke Jonas , Snethlage Mark A. , Stauffer Kerrie L. , Nussbaumer Jasmine , Schweizer Dominic , Diffenbaugh Noah S. , Fischer Markus , Urbach Davnah
Published: December 2022

Indicators of biodiversity protection at the national level are used to assess progress toward global goals. However, they provide little information at scales relevant for conservation and management. Hence we provide an area-based alternative to the current indicator calculated at the level of individual mountain ranges, which is directly relevant for assessing progress toward SDG 15.4.1. This allows identifying mountain areas in need of enhanced conservation efforts, within and across countries.
A New Molecular (P)Layer in Pseudomyxoma Peritonei: The Splicing Machinery is Dysregulated and Linked to Low Survival
Authors: Moreno-Montilla María Trinidad , Alors-Pérez Emilia , Martínez-López Ana , Blázquez-Encinas Ricardo , García-Vioque Víctor , Rodríguez-Ortiz Lidia , Valenzuela-Molina Francisca , Rufián-Andújar Blanca , Granados-Rodríguez Melissa , Ortega-Salas Rosa , Vázquez-Borrego Mari C. , Romero-Ruiz Antonio , Castaño Justo P. , Arjona-Sánchez Álvaro , Ibáñez-Costa Alejandro
Published: December 2022

Purpose:
Pseudomyxoma peritonei (PMP) is a rare cancer that causes chronic and uncontrollable mucus accumulation, gradually leading to intraperitoneal organ adhesion, bowel obstruction, malnutrition, and eventually cachexia and death. Aggressive cytoreductive surgery and hyperthermic intraperitoneal chemotherapy offer the best results; but the probability of relapse remains high. The study of the distinct molecular layers underlying PMP is essential to understand its genesis and progression. Alternative splicing is emerging as a new player in all cancers, but its role in PMP is unknown. The aim of this work was to assess the splicing machinery status in PMP and determine its potential contribution to disease prognosis.
Methods:
A set of 62 splicing-related genes were evaluated in a cohort of 29 patients using a microfluidic array, and their levels were compared between tumor and non-tumor tissue and correlated to relevant clinical parameters. Selected components were validated by immunohistochemistry and subsequently studied in detail by enrichment analyses.
Results:
Results revealed a profound dysregulation of the splicing machinery at RNA/protein level, which allowed to distinguish between tumor and control tissues. Particularly, the splicing factors HNRNPK, MBNL1, PTBP1 and RAVER1were associated with poor prognosis and their expression was linked to TP53regulation and inflammation processes.
Conclusions:
These findings provide the first evidence for the dysregulation of the splicing machinery in PMP, suggesting that it could be functionally altered and play a role in this rare malignant disease. Therefore, its detailed understanding could help to identify novel prognostic biomarkers and therapeutic targets in PMP.
Implementation of Resource Allocation Technique for DVB-RCS Compliant Satellite Terminals in Test-bed Scenario
Authors: Roy Abhishek Kumar , Singhal Rajneesh , Saini Trilok K. , Kumar Satyendra , Dhaka Manoj K.
Published: December 2022

Satellite communication is advantageous for several reasons such as broad coverage, small installation time of remote user sites, and network services in inhospitable terrains, where installing terrestrial infrastructure is costly. With the advent of broadband multimedia satellites such as Ku and Ka band satellites, multimedia services to the satellite terminals are gaining momentum. Digital Video Broadcast Return Channel via Satellite (DVB-RCS) is an open standard developed by ETSI which has further standardized, commercialized and solved the problem of inter-operability of Ku Band satellite terminals. Satellite bandwidth is scarce therefore treated as precious resource. In the present paper, authors aim to develop and realize the resource allocation techniques in return link channel for DVB-RCS compliant satellite terminals. The paper provides method for giving preference to real time application in terms of early processing of allocation request generated against the real time traffic to reduce delay and also provides method to avoid parallel connection arises due to transmission of terminal on more than one frequency at a time. Authors have realised DVB-RCS resource allocation technique and have given simulation results.
3D-DCNN Classification of Retinal Diseases Using Artificial Intelligence Deep Patterns Generated from 3D-OCT Hyperspectral Images
Authors: Krishnan M. Mukesh , Ramya S. Thanga , Ramar K.
Published: December 2022

The automatic and exact classification of 3D Optical Coherence Tomography (3D-OCT) images is crucial for retinal machine diagnostics. We propose a novel hybrid computer-aided 3D-OCT analytical approach (HCAD3D-OCT) for discriminating Diabetic Macular Edema (DME), Choroidal Neovascularization (CNV), and drusen illnesses from normal Optical Coherence Tomography (OCT) imaging. The proposed hybrid learning method combines Region of Interest (RoI) segmentation based on central severe chorioretinopathy images with deep neural networks for retinal condition diagnosis. The suggested strategy includes location, segmentation, extraction, diagnosis, and classification. Effective feature fusion for merging OCT image data obtained using a 3D Deep Convolution Neural Network (3D-DCNN) with RoI segmentation phase characteristics is provided. These combined extracted characteristics predict OCT retina disorders. Fragmentation of retinal RoI sections helps concentrate attention on diagnostically important regions. Norm-VGG19 is a hybrid supervised neural network with regularized kernels. Norm-VGG19 is trained on a large testing set for RoI localization and classification. The system's efficacy has been tested. The Large Database of Annotated 3D-OCT v3 is used to test the model's competence. The research outcome illustrates with the intention of the proposed model has good efficiency, sensitivity, and specificity. Overall, we see a 98.8% accuracy rate, 99.4% sensitivity, and 98.2% specificity.
Identification of a pyroptosis-related prognostic signature in bladder cancer and RT-qPCR validation
Authors: Wang Wei , Yang Ke , Wang Shuang , Zhang Wei , Guo Qiang , Wu Bo , Chen Qian , Zhang Yanlong , Wang Jingqi
Published: December 2022

Bladder carcinoma (BC) remains one of the commonly occurring cancers worldwide. Pyroptosis promotes the development of various tumors, but its role in the progression of bladder cancer as well as its effect on prognosis remain unclear. TCGA dataset was used as training set, GSE32894 as well as GSE48276 were used as test sets. We identified 19 DEGs related to pyroptosis between bladder cancer tissues and normal bladder tissues, 6 genes were further clarified as prognosis-associated genes. Through stepwise K-M analyses and stepwise multiCox analyses, we established a prognostic model, and the model had high specificity and sensitivity in predicting the patients’ prognosis. Independence analysis suggested that the survival of bladder cancer patients could be independently predicted by the risk signature. Further, we found differences in tumor immune cells infiltration, tumor mutation burden (TMB), immune checkpoints, and drug sensitivity among different risk groups. Our study confirmed the critical prognosis role of pyroptosis-related genes in bladder cancer. Our prognostic model may offer a new perspective for the therapy of bladder cancer.
State of the art review on automatic sorting system for industrial robots using Internet of Robotic Things
Authors: Gueye Thierno , Wang Yanen , Mushtaq Ray Tahir , Rehman Mudassar , Ahmed Ammar , Ali Haider
Published: December 2022

The idea for the Internet of Robotic Things (IoRT) comes from activities. IoRT allows smart devices to combine sensor information from multiple sources, use broader nearby insights to determine the best reason for the activity and display events on-screen. The Internet of Things can connect web applications to other gadgets to make them smarter. Automated engineers combine the two and arm themselves with sensors that can analyze the current situation. Mechanical improvements such as ordinary voice links (PC) vision sensor innovations and artificial intelligence (AI) have resulted in a turn of events and programmed placement frameworks under advanced machinery. This article examines frameworks for arranging programmed objects to assemble robots and innovative patterns in ordinary language programmed programming, and three-dimensional (3D) visual insight. The relevant statement "regulation scene" should describe the combination of all three modules. This computation enables people to relate through a three-tiered information scene and guides managers to use discourse to provide reasonable criteria whenever an order is legitimate. After receiving precise criteria, the robot can use this diary's planned execution calculations and programmed programming to direct the placement of programmed items. The play area provides a context for the natural product, while the landscape design provides a valuable part of the framework.
Contextually Intelligent Decisions: A Co-designed Approach for Commercial Driving Assessment
Authors: Mase Jimiama Mosima Mafeni , Pekaslan Direnc , Agrawal Utkarsh , Chapman Peter , Wagner Christian , Figueredo Grazziela
Published: December 2022

Commercial driving is a complex multifaceted task influenced by drivers' personal traits and external contextual factors, such as weather, traffic, and road conditions. Current intelligent commercial driving assessment systems only focus on the manner by which drivers operate vehicle controls when analysing driving performance and the impact of driver behaviour on road safety, potentially producing incomplete and unfair assessments. In this paper, we introduce a stakeholder co-designed approach to complement current driver-assessment systems and provide more context-aware, comprehensive and we hope--fairer assessments of commercial driving. The approach engages key stakeholders in the commercial driving sector to capture the impact of personal traits and external contextual factors on driving performance and provides a systematic approach to embed this knowledge into the assessment of commercial drivers. We demonstrate the effectiveness and utility of the approach by illustrating its end-to-end deployment in the context of heavy goods vehicle driving assessment.
Fast Ethics - Making Ethical Decisions in Mental Health During Covid – a case study
Authors: Beale Russell , Leitao Filipe
Published: December 2022

We report on the structure set up within Birmingham & Solihull Mental Health Foundation Trust in the UK to give advice and guidance on a range of ethical challenges arising as a result of the Covid-19 pandemic. The principles behind the group, its approach to decision making and a summary of the issues referred to it are represented, as well as our reflections on the potential usefulness of the group outside of the pandemic.
Data fusion using neural networks for intelligent multilevel control of artificial and natural objects: a survey
Authors: Tianxing Man , Osipov Vasiliy , Zhukova Nataly , Subbotin Alexey
Published: December 2022

In the modern world, data fusion (DF) technique has been playing an increasingly important role for effective and efficient data transformation in subject domains. DF aims to solve the problem of control of artificial and natural objects. Although DF has been intensively studied, neither unified problem statements of the fusion of the heterogeneous, multimodal, complex, imperfect data nor in-depth elaboration of characteristics and challenges about the application of DF on such specific situations are available. It is also unclear to what extent DF challenges have been addressed and what the overall research landscape of DF is. We define the requirements for DF in the interests of intelligent control of artificial and natural objects and look at the applications, reveal the capabilities of traditional DF methods and analyze the advantages that neural networks (NN) have over them. We show that despite of the evident advantages, none of the existing NNs satisfy all the requirements of DF. Based on the analysis of NN architectures, we determine the requirements for advanced NN architectures and discuss future research directions.
EGCG inhibits atrial fibrosis and reduces the occurrence and maintenance of atrial fibrillation and its possible mechanisms
Authors: Li Tao , Tong Qi , Wang Zhengjie , Yang Ziqi , Sun Yiren , Cai Jie , Xu Qiyue , Lu Yuan , Liu Xuemei , Lin Ke , Qian Yongjun
Published: December 2022

Purpose The aim of this study was to investigate the effect and mechanism of epigallocatechin-3-gallate (EGCG) on atrial fibrillation (AF) in rats.
Methods A rat AF model was established by angiotensin-II (Ang-II) induction, to verify the relationship between atrial fibrosis and the AF. The expression levels of TGF-β/Smad3 pathway molecules and lysyl oxidase (LOX) in AF were detected. Subsequently, EGCG was used to intervene Ang-Ⅱ-induced atrial fibrosis, to explore the role of EGCG in the treatment of AF and its inhibitory mechanism on fibrosis. It was further verified that EGCG inhibited the production of collagen and the expression of LOX through the TGF-β/Smad3 pathway at the cellular level.
Results The results showed that the induction rate and maintenance time of AF in rats increased with the increase of the degree of atrial fibrosis. Meanwhile, the expressions of Col I, Col III, molecules related to TGF-β/Smad3 pathway, and LOX increasedsignificantly in the atrial tissues of rats in the Ang-II induced group. EGCG could reduce the occurrence and maintenance time of AF by inhibiting the degree of Ang-induced rat atrial fibrosis. Cell experiments confirmed that EGCG could reduce the synthesis of collagen and the expression of LOX in cardiac fibroblast induced by Ang-II. The possible mechanism is to down-regulate the expression of genes and proteins related to TGF-βSmad3 pathway.
Conclusion EGCG could downregulate the expression levels of collagen and LOX by inhibiting the TGF-β/Smad3 signaling pathway, alleviating Ang-II-induced atrial fibrosis, which in turn inhibited the occurrence and curtailed the duration of AF.