bluuebunny/crossref_metadata_2025 huggingface dataset:
Facile and versatile fabrication of multifunctional cotton fabrics with persistent antibacterial and deodorizing properties
Authors: Han Hongwei , Hu Jiangtao , Zhou Jialiang , Gu Jiawei , He Xiang , Gao Qianhong , Wu Guozhong
Published: September 2024

Endowing cotton fabrics with enduring antibacterial and deodorizing functions while maintaining their original hygroscopic properties is a significant challenge. In this study, a novel surface-modified cotton fabric (Cot-g-PAA/PHMG) was prepared through irradiation-induced graft polymerization of acrylic acid (AA), followed by electrostatic adsorption of polyguanidine salt (PHMG). The influence of PAA/PHMG loading on the structure and overall performance of Cot-g-PAA/PHMG was thoroughly investigated and compared with the original cotton fabric. The results showed that the PAA/PHMG layer significantly enhances the antibacterial and deodorizing properties of the cotton fabric. Specifically, Cot-g-PAA/PHMG can absorb both acidic and alkaline gaseous pollutants due to its amphoteric structure, achieving removal rates of 95.3% for ammonia and 98.4% for acetic acid, after 50 rounds of accelerated washing, the deodorization rate of Cot-g-PAA/PHMG remains above 90%. Additionally, the guanidine-functionalized cotton fabrics exhibit antibacterial rates of up to 99.99% against Gram-negative Escherichia coli and 99.99% against Gram-positive Staphylococcus aureus, even after 50 laundering cycles. These findings provide a simple and versatile approach for creating antimicrobial and odor-resistant materials for hygienic applications.
A study on the efficacy of Group PM+ on depressed mood in medical students
Authors: Zhang Bing , Ji Sifan , Cui Yuqiu , Guo Yang , Jiang Cheng , Yang Tingting , Yu Fengqiong , He Kongliang
Published: September 2024

Objective：The prevalence of mental health problems among medical students is higher than that of students in other disciplines and continues to increase, which may pose a risk to medical students in their subsequent studies and careers. This study adopts a Group Problem Manager Plus (PM+) intervention with medical students and investigates its effectiveness. The study demonstrates the effectiveness of Group PM+ at treating depressed mood and mental health illnesses, providing an important theoretical and experimental basis for new therapies to improve the physical and mental health of medical students.
Methods: (1) Participants: Fifty-two participants were recruited through online distribution of the scale and randomly divided into an experimental group (received 5 weekly sessions of the Group PM+ intervention) and a control group (sharing psychology knowledge online only) after interviewing each participant individually. (2) Scales: The participants in both groups completed pre- and post-tests that included the Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder-7 (GAD-7), UCLA Loneliness Scale, Toronto Alexithymia Scale (TAS), and Chinese version of the Interpersonal Reactivity Index (IRI-C).
Results: (1) The results of the repeated measures ANOVA showed a significant improvement in depressed mood in Group PM+ (F1,43 = 10.460, P = 0.002) and significantly improved anxiety (F1,43 = 19.007, P < 0.001). (2) The Group PM+ intervention also diminished feelings of loneliness due to depressed mood and partially improved alexithymia.
Conclusions: (1) Group PM+ interventions can effectively treat depression and anxiety in medical students, alleviate feelings of loneliness, and reduce alexithymia in this population.
Artificial Neural Networks based validation, DFT, thermal and biological evaluation of novel 4-aminoantipyrine derived Ru(III) complexes
Authors: S.S Salin Raj , Dhanaraj Chellaian Justin
Published: September 2024

Series of novel Schiff base ruthenium complexes were synthesized using 4-aminoantipyrine derivatives. Elemental analysis and molecular mass of synthesized complexes are in agreement with calculated values. Molar conductance measurement reveals electrolytic property. Infrared spectral data reveal the ligands as tetra dentate coordinated to metal ions via imine nitrogen atom. All the complexes show octahedral geometry, which was identified by electronic spectra and magnetic measurements. Cyclic voltammetry analysis is used to identify the redox behavior of the complexes. XRD study of ligand and complexes reveal nano crystalline. The chelates exhibit high photo catalytic efficiency in UV-spectra with methylene blue dye. Thermal decomposition is in accordance with suggested formulae of the chelates. DFT computations have been used to determine the optimized molecular structure and bond parameters. The molinspiration calculations are used to identify the adherence of metal complexes to Lipinski’s rule of Five. Antibacterial screening was carried out against the bacterium B. Substilis, S. Aureus, E. Coli and K. Pneumoniae and two fungal species viz A. Niger and C. Albicans. Anticancer activity shows that the Ru(III) complexes exhibit noticeable cytotoxic effect in the SK-MEL-28 cell line. Analytical characterization was validated using Artificial Neutral Networks (ANN). New method has been adopted for automation, to get more accurate results compared to the previous existing machine learning models, the proposed Artificial Neural Networks achieved good testing accuracy.
Assessment of long-term channel morphological changes based on remote sensing techniques, Vistula River, Poland
Authors: Sosnowska Anna
Published: September 2024

The research presented in this paper is an attempt to characterise morphological processes that take place in the middle Vistula River channel. The research considered different cartographical materials (maps, aerial photographs) from 1959 to 2020. The chosen fragments of the middle reach of the Vistula River were analysed for changes in the channel bar size and changes in the channel width. It was stated that changes in the river width are the reason for the emergence of channel bars. The bars that were examined are stable, and they are located at a certain distance from the river narrowing. At some of the locations, the erosion-sedimentation processes are still taking place. A methodology for river channel deformation assessment based on a comparison of aerial photographs was proposed in this research. This methodology is unique and can be successfully utilised for river channel assessment. The results provide important knowledge about the characteristics of channel processes in the middle Vistula River reach that can be used for future river management.
Emergence of the North Pacific heat storage pattern delayed by decadal wind-driven redistribution
Authors: Li Yuanlong , Duan Jing , Lyu Yilong , Jing Zhao , Wang Fan
Published: September 2024

Storage of anthropogenic heat in the oceans is spatially inhomogeneous, impacting regional climates and human societies. Climate models project enhanced heat storage in the mid-latitude North Pacific (MNP) and much weaker storage in the tropical Pacific. However, the observed heat storage during the past half-century shows a more complex pattern, with limited warming in the central MNP and enhanced warming in the northwest tropical Pacific. Based on observational datasets, ocean model experiments, and climate models, we show that emergence of human-induced heat storage is likely postponed in the North Pacific by natural variability to the late-21st century. Specifically, phase shifts of the Pacific Decadal Oscillation (PDO) have vitally contributed to trends in the North Pacific winds during recent decades. Changes in surface winds drove meridional heat redistribution via Rossby wave dynamics, leading to regional warming and cooling structures and a more complex historical heat storage than models project. Despite this, enhanced anthropogenic warming has already been emerging in marginal seas along the North Pacific basin rim, for which we shall prepare for the pressing consequences such as increasing marine heatwaves.
Global prevalence of human brucellosis: A systematic review and meta-analysis
Authors: Sherasiya Riyaz
Published: September 2024

Background and aim: Human brucellosis caused by various Brucella species is a significant global health concern, particularly in livestock-dependent regions. The disease presents with non-specific symptoms like fever, fatigue, and joint pain, often leading to complications such as endocarditis and arthritis. Accurate diagnosis of this condition is challenging due to its diverse clinical manifestations and similarities to other febrile illnesses. This study aimed to provide a comprehensive synthesis of literature on the global prevalence of human brucellosis, providing updated insights and recommendations for improving diagnostic methods and public health strategies.
Materials and Methods: In this study, a systematic search of Web of Science and Scopus was performed to extract studies from January 2000 to December 2022 using keywords “Brucellosis”, “Brucella”, “prevalence of Brucella”, “prevalence of brucellosis”, “epidemiology of Brucella”, and “epidemiology of brucellosis”. Extracted data were than imported to HubMeta, duplicates were removed, and relevant studies (original articles/abstracts in English) were screened by reviewing titles, abstracts, and full texts. Cross-sectional and retrospective studies on brucellosis prevalence were included, while case reports with fewer than ten patients, clinical trials, and studies without clear sample sizes were excluded. Data were extracted into an Excel sheet and analyzed using the Meta Essentials tool to calculate pooled, gender-specific prevalence, and continent-specific prevalence with results visualized using forest plots.
Results: Sixty-nine studies with a sample size of 2,00,1236 were included in the review. The pooled prevalence of brucellosis was 15.49% (95% CI: 12.01–18.97), with the highest prevalence observed in Palestine (76%) and the lowest in Brazil (0.64%). The prevalence by continent was 16.65% in Asia, 16.28% in Africa, and 11.09% in America. The gender-specific prevalence was 19.11% in males and 13.97% in females.
Conclusion: This meta-analysis revealed significant regional and gender disparities in the prevalence of brucellosis, with high rates in Asia and Africa and a higher prevalence in males due to occupational exposure. However, limitations such as language bias, high study heterogeneity, and uneven study distribution across countries may affect the generalizability of the results. Standardized diagnostic methods and targeted public health interventions are essential to reduce the impact of brucellosis.
Dynamics of duplicated gene regulatory networks governing cotton fiber development following polyploidy
Authors: Hu Guanjing , Xiong xianpeng , Zhu De , Grover Corrinne , Wendel Jonathan , Ma Xiongfeng
Published: September 2024

Cotton fiber development entails complex genome-wide gene regulatory networks (GRN) that remain mostly unexplored. Here we present integrative analyses of fiber GRNs using public RNA-seq datasets, integrated with multi-omics genomic, transcriptomic, and cistromic data. We detail the fiber coexpression dynamics and regulatory connections, validating findings with external datasets and transcription factor (TF) binding site data. We elucidate previously uncharacterized TFs that regulate genes involved in fiber-related functions and cellulose synthesis, and identify the regulatory role of two homoeologous G2-like transcription factors on fiber length. Analysis of duplicated gene expression and network relationships in allopolyploid cotton, which has two co-resident genomes (A, D), revealed novel aspects of asymmetric subgenomic developmental contributions. Whereas D-based homoeolog pairs drive higher overall gene expression from the D subgenome, TFs from the A subgenome play a preferential regulatory role in the fiber gene regulatory network. Following allopolyploid formation, it appears that the trans-regulatory roles of TFs diversified more rapidly between homoeologs than did the cis-regulatory elements of their target genes. Our approach underscores the utility of network analysis for detection of master regulators and provides fresh perspectives on fiber development and polyploid functional genomics, through the lens of co-expression and GRN dynamics.
Introducing a Validation Technique for Corridor Modeling: A Comprehensive Evaluation of Predicted Wildlife Corridors in Modern Conservation Strategies
Authors: TIWARI AMRAPALI , Saran Sameer , Avishek Kirti
Published: September 2024

Effective biodiversity conservation strategies are paramount in addressing the persistent challenges of habitat fragmentation. This study investigates landscape connectivity for tigers across eight protected areas in Haryana, Uttarakhand, and Uttar Pradesh within the Terai Arc Landscape. Utilizing the least cost path methodology, the research identifies the most probable pathways connecting these protected areas. Additionally, circuit theory is employed to highlight crucial conservation areas, termed pinchpoints. The primary objective is to introduce a triangulation-based validation technique for predicted corridors, calculating the accuracy of predicted corridors between the eight protected areas. The results reveal several pinchpoints that require immediate action. The highest prediction accuracy is observed for the corridor between Rajaji National Park and Sonanadi Wildlife Sanctuary/Jim Corbett National Park, whereas the lowest accuracy is noted between Jim Corbett National Park and Kishanpur Wildlife Sanctuary. This research advances the precision and credibility of corridor modeling, offering significant contributions to wildlife conservation by elucidating landscape connectivity and presenting a novel validation technique. The findings provide practical implications for policymakers, conservation practitioners, and researchers, underscoring the need for rigor and validation in developing effective strategies to preserve and sustainably manage wildlife habitats.
Anxiety, depression and other internalizing problems of young children in low and middle-income countries before the covid-19 pandemic
Authors: Martinez Adriana Maldonado , Caetano Sheila C , Davidson Leslie L , Muszkat Débora , Silva Luis M , Wilches-Gutierrez Jose L , Surkan Pamela J , Martins Silvia S
Published: September 2024

Introduction:This study addresses the scarcity of research on the characteristics of young children's internalizing problems in Low and Middle-Income Countries (LMICs) through a systematic review of pre-pandemic literature. It aims to provide essential insights into understanding, preventing, and intervening in internalizing problems among young children. Additionally, it lays the groundwork for future studies to explore the effects of the pandemic on mental health in young children, including potential changes in the prevalence and nature of internalizing problems.Methods:The systematic review included thirty-one studies from LMIC studies published in English, Spanish, or Portuguese before March 2020 focusing on predictors, mediators, and characterizations of internalizing symptoms in preschoolers. The studies were classified by region to identify commonalities, interests, and differences.Results:The review revealed a significant disparity in research representation across regions, with the Americas being the most extensively studied and regions like the Eastern Mediterranean and Southeast Asia lacking adequate research. Validation of behavioral problem scales in LMICs was limited, posing challenges to accurate measurement. However, findings highlighted common risk factors such as maternal characteristics and environmental influences.Conclusions:Despite limitations, this review emphasizes the urgent need for comprehensive research on internalizing problems in preschoolers, particularly in LMICs. Broadening linguistic inclusion criteria and prioritizing validation efforts for behavioral problem scales are crucial steps towards addressing research gaps. Furthermore, highlighting common risk factors and patterns across regions underscores the importance of collaborative efforts to inform effective interventions and support child mental health globally.
Efficacy of Metarhizium anisopliae against Bactrocera cucurvitae under in-vitro conditions: A meta-analysis
Authors: Salibo Andal U.
Published: September 2024

This study evaluated the effectiveness of the entomopathogenic fungus Metarhizium anisopliae in controlling the cucurbit fruit fly Bactrocera cucurbitae under in-vitro conditions. This research aimed to develop sustainable and eco-friendly pest management strategies to replace traditional chemical pesticides. The experiment employed a randomized complete block design with five concentrations of M. anisopliae spore solution, replicated four times with 20 fruit flies each. The media for the fungus were prepared and purified, and fruit flies were collected using pheromone traps. The treatments were applied via the spray method, and data on mortality rates, mummification times, and toxicity levels were collected. Statistical analyses, including ANOVA and log-probit analysis, were also conducted to determine the lethal concentrations and durations. The results indicate a clear dose response relationship, with higher spore concentrations leading to significantly increased mortality rates and faster mummification. A concentration of 6.0 × 105 CFU/mL was necessary for substantial population reduction, while the projected lethal concentrations for 50% and 99% mortality were approximately 2.65 × 105 CFU/mL and 1.38 × 105 CFU/mL, respectively. These findings suggest that M. anisopliae is a highly effective biocontrol agent against B. cucurbitae, and is a viable alternative to chemical pesticides. Further research is recommended to explore field applications and assess long-term ecological impacts.
Levando a neurociência para todos - experiências do programa Popneuro em ações de divulgação científica
Authors: RIBEIRO Pedro Igo Lopes , CRESPO Bruna Tarasuk Trein , TADIELO Ana Luiza Trombini , ROSA Patricia Altermann Batista da , PINTO Pâmella Andrea Machado da Silva Laranja , MELLO-CARPES Pâmela Billig
Published: September 2024

A divulgação da neurociência, destacando-se pelo estudo do cérebro e suas funções, ganha importância na educação e sociedade. Através de esforços contínuos, como palestras e o uso inteligente das mídias sociais, a neurociência se aproxima do público. Estudantes universitários, especialmente os envolvidos com o Programa POPNEURO da Universidade Federal do Pampa, em Uruguaiana, RS, desempenham papel fundamental, agindo como embaixadores científicos. As atividades, incluindo a Semana Internacional do Cérebro, feiras de ciências e Neuroblitzes em escolas, além da capacitação de professores, fomentam o interesse e compreensão sobre o Sistema Nervoso. Essas ações, marcadas pela inovação, não só informam, mas também inspiram e engajam a comunidade, fortalecendo a cultura científica e a aplicação prática do conhecimento neurocientífico no cotidiano. As ações exemplificam o impacto transformador daneurociência na educação e engajamento público, evidenciando seu valor além da academia.
Изменение клинических и лабораторных показателей в зависимости от тяжести травматического шока: ретроспективное когортное исследование
Authors: Лахин Роман Евгеньевич , Кусай А. С. , Усольцев Е. А. , Касимов Р. Р. , Цыганков К. А. , Старостин Д. О. , Шустров В. В. , Щеголев А. В.
Published: September 2024

INTRODUCTION: Traumatic shock is a complex pathophysiological process that includes impaired tissue perfusion, the development of circulatory and tissue hypoxia, metabolic disorders, and homeostasis disorders.
MATERIALS AND METHODS: A retrospective cohort study that included 329 people with combat injury. The level of systolic blood pressure (SBP), heart rate (HR), acid-base state (CBS), general and gas blood tests were examined upon admission.
RESULTS: There were 55 patients without shock (30 %), 83 (25 %) with I degree shock, 80 (25 %) of II degree, 51 (15 %) of III degree, 16 (5 %) of IV degree. The analysis of the values of the SBP, HR and shock index (SI), base deficiency (BE) showed the presence of statistical differences depending on the degree of shock. SI without shock was 0.7 (0.7; 0.8); with shock of the I degree — 0.8 (0.7; 0.9); II degree — 1.3 (1.1; 1.5), III degree — 1.8 (1.5; 2.1), IV degree — 2.5 (2.1; 3.8). The value without shock was –3.1 (3.9; –2.2); with degree I shock –3.7 (–2.1; –6.2); II degree: –4.6 (–3.1; –6.8); III degree: –8.5 (–6.5; –11.8); IV degree: –22.1 (–15.6; –26.1). Regression analysis of the relationship with the degree of shock showed two models that described a 45.9 % and 50.2 % probability. The first model includes a constant and VE (p < 0.01). The second model includes the constant, VE and the number of platelets (p < 0.01). CONCLUSION: A retrospective analysis of clinical and laboratory parameters for traumatic shock demonstrated differences in SBP, HR, SI, red blood counts, CBS, lactate levels depending on the degree of shock. The severity of acidosis and lactate levels turned out to be higher than expected for the degree of shock, due to the nature and severity of the injuries received. Base deficiency and platelet count were associated with the severity of shock.
EXFOLIATIVE CYTOLOGY OF SEROUS FLUIDS- AN IMPORTANT AID TO PRIMARY DIAGNOSIS
Authors:   Senior Resident, Department of Pathology, B.J. Medical College, Ahmedabad, India., Marakana Nirali , Vaghani Jayshree ,   Senior Resident, Department of Pathology, B.J. Medical College, Ahmedabad, India., Faldu Bhavesh ,   Assistant Professor, Department of Pathology, B.J. Medical College, Ahmedabad, India., Goswami Hansa ,   Professor & HOD, Department of Pathology, B.J. Medical College, Ahmedabad, India.
Published: September 2024

Introduction: Body fluid cytology is an important diagnostic test for various malignant and benign conditions. Effusions can be caused by inflammatory, infectious, and benign neoplastic or malignant and primary or metastatic diseases. Such conditions in effusions may often have overlapping features and mimic one another both cytomorphologically and clinically, presenting diagnostic challenges.1 Aims and Objectives: To study tha age and gender wise distribution of cases. To the study the incidence of neoplastic and non-neoplastic lesions. To study the cytomorphology of neoplastic and non-neoplastic lesions. Material and Methods: This prospective study was carried out at B.J Medical College,Ahmedabad during the period of 1stApril 2024 to 31stMay 2024 for a period of 2 months. Fluids were received in the department of cytopathology.After receiving the fluid sample, details like type of fluid, clinical diagnosis, age and gender of the patient were noted. Gross description of fluid including volume, colour, turbidity, were noted and fluid and fluid was taken up for processing in which immediately the sample was centrifuged and the sediment smear were made.Sediment smear were stained by Hematoxylene and Eosin,Pap stain and May grunwald giemsa (MGG) stains.After staining slides were mounted with DPX, screened and reported by pathologist according to The International system (TIS) for reporting serous fluid cytology 2020. Results: Total 100 serous fluids were received in 2 months.Out of which peritoneal fluid were 65 and pleural fluid were 35. M:F ratio was 1.12. 2 % fluids were inadequate for reporting87% fluid were negative for malignancy(NFM).6% fluid were given as atypia of undetermined significance(AUS).Malignant for secondary (MAL-S) were 5%. Conclusion: We conclude in our study that cytology is a valuable tool in evaluation of serous cavity fluids. It is relatively painless, simple, cost effective, rapid technique that yields quick and reliable results.
TEACHING EFFECTIVENESS OF TEACHER EDUCATORS IN RELATION TO THEIR WELL-BEING
Authors:   Ph.D. Research Scholar, Swami Vivekananda Center for Multidisciplinary Research in Educational Studies, University of Calcutta Recognized Research Center Under Ramakrishna Mission Sikshanamandira, Belur Math, Howrah, West Bengal., Ghosh Bikash , Tattwasarananda Swami ,   Professor of Education, Ramakrishna Mission Sikshanamandira, Belur Math, Howrah, West Bengal., Satpati Lakshminarayan ,   Professor of Geography & Director of UGC-HRDC, University of Calcutta.
Published: September 2024

Generally teaching is delivered by a teacher to enhance the amount of effective learning of a learner. To make learning more meaningful, understandable and fruitful to a learner, effectiveness of teaching delivered by a teacher is very essential condition. This concept of teaching-learning process is not exceptional one in case of teacher training institutions. Other side Teachers professional wellbeing provides information about statement of teachers in terms of teaching profession. In order to strengthen the role of teacher educators, it is needed to look at their all round well-being. Present study was conducted to find out if there was any significant mean difference in teaching effectiveness and well-being of teacher educators in respect to gender, location and types of colleges (Govt./Non-Govt.) in West Bengal and to establish the relationship between teaching effectiveness & well-being of teacher educators. ITAS and GWBS scales were administered on 344 randomly selected teacher educators of B.Ed. colleges for measuring their teaching effectiveness and well-being variability according to their categorical variations and relationship of teaching effectiveness and well-being. The descriptive survey method was used for the present study. The finding of this study indicated that educators teaching effectiveness differed significantly in maximum cases while to compare in respect to the gender, and college types but the difference was insignificant in relation to the location of the college. Regarding wellbeing of teacher educator, no significant difference was found in respect to the difference of gender or the area from which college belongs and college types of the teacher educators. The present study also explored the relationship between teaching effectiveness and well-being of teacher educators and overall result showed positive relationship between the variables.
EFFECT OF MAHATRIPHALADYA GHRITA SNEHAPANA (INTERNALOLEATION) IN THE MANAGEMENT OF DYSLIPIDEMIA (MEDODUSHTI)-A CASE REPORT
Authors:   P.G Scholar, Post Graduate Department of Panchakarma, Ch.Brahm Prakash Ayurved Charak Sansthan Khera Dabar, New Delhi-110073., and Pooja , Gupta Arun ,   Professor and Head, Post Graduate Department of Panchakarma, Ch.Brahm Prakash Ayurved Charak Sansthan Khera Dabar, New Delhi-110073.
Published: September 2024

Dyslipidemia is a condition that can lead to various diseases in the future. There is a 1-2% increase in the incidence of coronary heart disease for every 1% increase in cholesterol levels. This condition is considered as a lifestyle metabolic disorder, primarily caused by poor dietary habits, lack of physical activity, and stress. Although Ayurveda does not have a direct reference to Dyslipidemia, its clinical characteristics and etiopathogenesis is imply that it can be classified under the broad categories of Santarpanjanyavyadhi, Medopradoshaja Vikara, Medodushti, and Medosrotodusti. The aim of this study was to treat Dyslipidemia using Shamana Snehapana. Lipid profile was selected as criteria for the assessment of Dyslipidemia. Mahatriphaladya Ghrita was chosen for Shamana Snehapana as its ingredients have hypolipidemic qualities. A 40 years old female patient reported in Panchakarma OPD with increase in serum cholesterol level, serum triglycerides level and serum LDL level. She was administered with Mahatriphaladya Ghrita Snehapana (internal oleation) for 14 days with a gap of 3 days after 7 days of Snehapana and shows significant improvement in Serum cholesterol level and LDL level. This improvement can be due to the correction of Agni by Snehpana and improved liver function. Therefore, this study concludes that Shamana Snehapana is safe and efficient for use in the treatment of Dyslipidemia.
CULTURA ORGANIZACIONAL Y CALIDAD DEL SERVICIO AL CLIENTE DE LA COOPERATIVA DE TAXIS DÁVILA CÓRDOVA DE LA CIUDAD DE CHONE
Authors: Calle García Aldrin Jefferson , Zambrano Zambrano Cindy Jaritza
Published: September 2024

El estudio aborda la problemática de cómo una cultura organizacional inadecuada puede afectar negativamente la calidad del servicio al cliente, cuyo objetivo principal fue determinar la incidencia de la cultura organizacional en la calidad del servicio al cliente dentro de la cooperativa. Metodológicamente, se utilizó un enfoque mixto, combinando métodos descriptivos, deductivos, inductivos y correlacionales. Se aplicaron encuestas y la entrevista a los 54 socios de la cooperativa. Los resultados mostraron que el 56% de los encuestados calificó la cultura organizacional como “buena”, mientras que el 48% consideró “buena” la formación en atención al cliente, aunque un 44% cree que los estándares de calidad del servicio solo se cumplen de manera “regular”. En conclusión, la cultura organizacional tiene una influencia significativa en la calidad del servicio al cliente, y aunque existen percepciones positivas, se identifican áreas clave que requieren mejoras, especialmente en la capacitación y en la implementación de estándares claros y efectivos.
Customer purchase decisions of clothing amongst students in Nigerian private universities: The effect of digital advertising
Authors: O. Ajike Emmanuel , A. Aderimiki Jeremiah , G. Bamidele Ayodeji , Idowu Nwankwere
Published: September 2024

With the proliferation of digital platforms, businesses, including clothing brands, increasingly leverage digital advertising to reach and engage their target audiences. However, limited research explicitly explores its influence on purchasing decisions in Nigeria, particularly among private university students. This research aims to determine the effects of digital advertising on customer purchase decisions for clothing among students. The study surveyed a target population of 450 students randomly selected from four private universities (Covenant University, Bells University of Technology, Crawford University, Crescent University) in Ogun State, Nigeria. The data collected from the field were subjected to analysis using multiple linear regression. The results revealed that digital advertising affects consumer purchase decisions among students of private universities. Specifically, digital advertising has a significantly positive effect on customer awareness (adj. R2 = 0.220, F (4, 416) = 30.294, p < 0.05); customer interest (adj. R2 = 0.112, F (4, 416) = 14.024, p < 0.05), and customer purchase desire (adj. R2 = 0.102, F (4, 416) = 12.758, p < 0.05). Thus, this study recommends that any clothing businesses targeting students for sales growth and sustainability in Nigerian universities should leverage digital advertising. The result further noted the need to focus on variables such as search engine optimization, social media, and digital influencers to boost customer purchase decisions.
Psoriasis of a pilar part of the head - pathogenetic therapy
Authors: Kovaleva Ju. S. , Komkina N. G.
Published: September 2024

The relevance of psoriasis is caused by prevalence of a disease, a long chronic current, frequent, is long the proceeding recurrence. According to modern representations psoriasis - one of the most widespread chronic inflammatory dermatosis with primary damage of skin and probably genetically determined immune disturbances which are implemented under the influence of a number of trigger factors, demonstrating inflammatory process in a derma, are followed by permanent disturbance of proliferation and a morphological differentiation of keratinotsit. Diverse clinical manifestations are characteristic of psoriasis: from the single, plentifully shelled papules or plaques of pinkish-red color to an erythrosis, psoriasis arthritis, generalized or limited pustulous psoriasis. Defeat of a pilar part of the head - the most widespread localization of a dermatosis also meets at 80% of patients with psoriasis, in 25% of cases psoriasis of skin of a pilar part of the head proceeds separately. Fast and effective treatment of psoriasis of a pilar part of the head is of great importance as the worst indicator of the index of quality of life is noted at patients with this problem - 82% of the patients suffering from a dermatosis have constant feeling of discomfort and are stigmatized that serves as the reason of deep social isolation and disadaptation. According to the clinical recommendations of the Russian society of dermatovenerologists about external therapy of psoriasis with manifestations on a pilar part of the head, topical glucocorticosteroids in a combination with salicylic acid in the form of various dosage forms belong to drugs of the first line. In article data of own clinical experience of use of the solution containing betamethasone Dipropionas and salicylic acid are stated (Akriderm of SK solution). The good efficiency of medicine concerning psoriasis on a pilar part of the head, convenience of use of a dosage form in the form of solution, fast approach of clinical result at patients with involvement of head skin is noted.
Thyroid dysfunction during pregnancy: when and whom to treat?
Authors: Dolgikh Yu. A. , Bulgakova S. V. , Sharonova L. A. , Kosareva O. V. , Treneva E. V. , Merzlova P. Ya. , Kurmayev D. Р.
Published: September 2024

The thyroid gland is an important organ of the endocrine system. Its hormones influence all human organs and systems. Among thyroid dysfunctions, the most common variant is primary hypothyroidism. Since during pregnancy the mother's thyroid gland undergoes changes and the need for thyroid hormones increases, the risk of hypothyroidism increases. Particular attention should be paid to women who are carriers of antithyroid antibodies, as they are more likely to have thyroid dysfunction during pregnancy. In this regard, such patients should have their thyroid function examined in each trimester of pregnancy. It is known that hypothyroidism, both manifest and subclinical, has a negative impact on pregnancy outcomes and the subsequent psycho-physical development of the child. With obvious hypothyroidism, the risk of premature birth, arterial hypertension, preeclampsia and other complications increases. Therefore, treatment for hypothyroidism during pregnancy should begin immediately. The basis of treatment for this pathology is the prescription of replacement therapy with L-thyroxine immediately in a full replacement dose. For women who were already taking the drug before pregnancy, the dose of L-thyroxine increases by 20-30% with the onset of gestation. Also during pregnancy, there may be a decrease in thyroid hormones, usually thyroxine (T4w), with normal TSH. This condition is called isolated hypothyroxinemia. Its causes may be insufficient iodine intake, as well as increased levels of thyroxine-binding globulin. Its increase leads to an increase in the concentration of the total fractions of the hormones T4 and T3, but at the same time the true level of T4fr is underestimated. Isolated hypothyroidism does not require treatment if TSH levels are normal.
Sitagliptin is a time-tested leading drug in the treatment of type 2 diabetes
Authors: Kononenko I. V. , Smirnova O. M.
Published: September 2024

Dipeptidyl peptidase type 4 (DPP-4) inhibitors hold leadership positions in the treatment of type 2 diabetes worldwide due to their pathogenetically substantiated mechanism of action, low risk of hypoglycemic states and good tolerability. Today, they represent the largest class of glucose-lowering medicines. Sitagliptin, the first antidiabetic agent from this class, is the best known one and along with that remains the most promising medicine. It can be prescribed either as the initial treatment or later in a combination with other classes of hypoglycemic drugs, including sulfonylurea derivatives. Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (GIP), which blood concentrations increase under the effect of DPP-4 inhibitors, enhance glucose-stimulated insulin secretion through activating the cyclic adenosine monophosphate (cAMP) signaling pathway in pancreatic β-cells, meanwhile cAMP plays a critical role in an increase in β-cell sensitivity to glucose. Sitagliptin is an antidiabetic agent with significant data on cardiovascular safety. The efficacy of the drug is broadly similar to that of sulfonylurea derivatives. At the same time, the low risk of hypoglycemic states and the absence of side effects create certain advantages of using this drug in elderly patients. Active use of the drug in patients with diabetes in Japan is associated with the predominance of secretory disorders in the pathogenesis of the disease and the efficacy of DPP inhibitors in this ethnic group. The pleiotropic properties of the drug continue to be studied. The positive effects of sitagliptin in coronavirus infection may be associated with the anti-inflammatory and immunomodulatory properties of the drug. The potential of the drug in the treatment of immune-mediated conditions, as well as its neuroprotective properties in the prevention and treatment of Alzheimer's disease, are considered.
Cardioembolic stroke and endothelial dysfunction in men aged between 30 and 50 years
Authors: Pizov N. A. , Baranova N. S.
Published: September 2024

Introduction. Stroke in young adults is associated with high-level socioeconomic components, and patients face the lifelong effects of the vascular catastrophe. Young patients with cardioembolic stroke make up an important subgroup of ischemic stroke patients globally. A key to optimizing treatment and preventing relapses is identifying the causes and risk factors for ischemic stroke in young adults.

Aim. To assess risk factors and endothelial function status in young men with cardioembolic stroke

Material and methods. A total of 19 patients aged 30-50 years with cardioembolic stroke underwent clinical and instrumental examinations. All patients were admitted to the Yaroslavl Vascular Center before the COVID-19 pandemic. The severity of clinical symptoms and stroke were assessed using the NIHSS scales, Modified Rankin Scale, and Rivermead Mobility Index. The main risk factors for IS including the presence of high- or moderate-risk sources of cardioembolism were reviewed. All patients underwent brain neuroimaging, ultrasound imaging, electrocardiogram, echocardioscopy, and laboratory blood testing. An ultrasound guided tourniquet test was performed to assess the brachial artery endothelial vasomotor function. 

Results. The average age of patients with cardioembolic stroke was 43.2 ± 6.4 years. Mechanical valve prostheses (21.1%) and isolated atrial fibrillation (42.0%) are the most common sources of cardioembolism. Other commonly identified risk factors included hypertension (73.7%), dyslipidemia (42.1%), smoking (52.6%), and prior acute myocardial infarction (42.1%). The ultrasound guided tourniquet test showed normal dilation of the brachial artery in 26.3% patients, insufficient dilatation in 42.1% patients and vasoconstriction in 31.6% patients. Statistically significant associations between the main vascular risk factors, serum markers of endothelial dysfunction and ultrasound guided tourniquet test indices were identified.

Conclusion. This study demonstrated a variety of risk factors for cardioembolic stroke in young men. Lifestyle modification is responsible for the occurrence of traditional risk factors in young adults.
Modern therapeutic nutrition in clinical practice
Authors: Minushkin O. N.
Published: September 2024

Настоящее сообщение представляет результаты симпозиума, проведенного в рамках XXXI Российского национального конгресса «Человек и лекарство», проходившего 15-18 апреля 2024 г. в Москве. Участниками симпозиума «Лечебное питание» были О.Н. Минушкин, Т.Л. Пилат, Л.В. Масловский, И.В. Зверков, А.Е. Евсиков, Ю.Г. Кузнецова, В.С. Иневатова; сопредседателями - О.Н. Минушкин и Т.Л. Пилат. На симпозиуме были освещены основные этапы развития отечественного лечебного питания, изложены основные требования и определено место лечебного питания в общей структуре лечения гастроэнтерологических больных. Представлены основные формы современных диет и лечебных продуктов, содержащих биологически активные компоненты, усиливающие эффекты фармакотерапии. Представлены материалы, характеризующие роль лечебного питания в терапии конкретных нозологических форм: хронического гастрита, острого и обострения хронического панкреатита, определено место лечебного питания в схемах эрадикации Helicobacter pylori, а также его детоксикационный эффект у пациентов, страдающих заболеваниями из группы метаболического синдрома и у онкологических больных. Целями и задачами симпозиума было представить результаты использования лечебного питания в терапии некоторых распространенных хронических неинфекционных заболеваний желудочно-кишечного тракта: хронического гастрита, хронического панкреатита, при онкологических заболеваниях, влияние применения лечебного питания при эрадикации H. pylori. Значимым аспектом представленных материалов является то, что лечебное питание было рассмотрено с позиции влияния на патогенетические звенья указанных нозологий, что важно, так как конгресс посвящен лекарствам.
Anti-inflammatory treatment of conjunctivitis against the background of shigellosis and chlamydia: clinical observations
Authors: Safonova T. N. , Zaitseva G. V.
Published: September 2024

Conjunctivitis accounts for about a third of all ocular pathology in clinical ophthalmology and is the most common inflammatory lesion of the eyes. This nosology can be both infectious and non-infectious in nature. The protection of the visual organ from exogenous and endogenous antigens is carried out with the help of highly specialized lymphoid tissue associated with the eye, which belongs to the peripheral organs of the immune system. The main task of the lymphoid tissue of the eye surface, which includes the conjunctiva, is to maintain a balance between the inflammatory immune response and tolerance to non-pathogenic factors, preventing the development of a permanent inflammatory reaction. Chronic conjunctivitis develops in patients with increased sensitization to a particular antigen. The article presents various aspects of pathogenesis, clinical picture, modern diagnostic methods, as well as management tactics for patients with chronic conjunctivitis of endogenous etiology, which developed against the background of systemic infectious diseases: shigellosis and chlamydia. The clinical efficacy of a combination of antibacterial drugs using the nonsteroidal anti-inflammatory drug bromfenac has been demonstrated. With a prolonged course of chronic conjunctivitis and the absence of a positive response to local therapy, additional examination is necessary to identify possible endogenous etiological factors.
The first biosimilar of ultra-rapid insulin lispro: results of a double-blind randomised clamp study
Authors: Noskov S. M. , Koksharova E. O. , Arefeva A. N. , Banko V. V. , Matvienko Yu. D. , Makarenko I. E. , Drai R. V.
Published: September 2024

Introduction. Over the years, insulin therapy has remained an important component of the complex treatment of patients with diabetes mellitus. Ultra-rapid insulin lispro is a DNA recombinant analogue of human insulin, which has a pharmacokinetic (PK) profile that is as close as possible to the endogenous insulin secretion profile, which ensures effective control of postprandial glycaemia. The development of the ultra-rapid insulin lispro biosimilar will expand the range and increase the availability of modern and safe insulin analogues for diabetic patients in Russia.

Aim. To compare the PK and pharmacodynamic (PD) profiles of GP40261 (ultra-rapid insulin lispro biosimilar) and the reference Lyumjev® in healthy volunteers.

Materials and methods. This was a double-blind, randomised, comparative, crossover study in healthy volunteers who were administered either the test or reference ultra-rapid insulin lispro formulation as a single dose of 0.3 IU/kg. The hyperinsulinaemic euglycaemic clamp technique was used to evaluate the pharmacokinetics and pharmacodynamics of the study products. In order to assess the biosimilarity of the products, 90% confidence intervals (CIs) were calculated for geometric mean ratios of the primary PK parameters AUCins.0-t and Cins.max. The PD parameters of the study drugs were evaluated based on the glucose infusion rate required to maintain the target glycaemic level during the clamp.

Results. The 90% CIs for the geometric mean ratios of the primary PK parameters for the test and reference products were 89.41-94.55% for AUCins.0-t and 82.74-92.92% for Cins.max, which complies with the established acceptance limits of 80-125% for both parameters. The study products were also found to have comparable PD profiles of their active substances.

Conclusion. This clinical study has demonstrated that GP40261 and the reference ultra-rapid insulin lispro are biosimilar and have a comparable safety profile.
Changes in the cardiovascular system in patients with diabetes mellitus
Authors:   Volgograd State Medical University, Vinogradova Marina , Skvortsova Ekaterina ,   Volgograd State Medical University, Skvortsov Vsevolod ,   Volgograd State Medical University
Published: September 2024

In recent years, there have been serious changes in the close relationship between diabetes mellitus and cardiovascular diseases. From the early stages of insulin resistance and prediabetes to serious cardiac complications caused by diabetes. Coronary heart disease is the main cause of morbidity and mortality in diabetic patients, but not all diabetic patients have an equally high risk of heart attacks. More than a third of asymptomatic patients have no signs of coronary atherosclerosis and have a very low annual heart attack rate. Early detection of patients with subclinical coronary artery atherosclerosis and/or significant obstructive coronary artery disease with asymptomatic myocardial infarction may help in making a therapeutic decision to prevent future devastating acute cardiovascular conditions. This article is devoted to the peculiarities of the course of cardiovascular diseases in concomitant diabetes mellitus, its role in increasing the frequency and severity of complications after acute cardiovascular episodes, as well as modern views on the therapy of this combined condition.
Oxidative stress and its role in epilepsy
Authors:   St. Petersburg State University, Tibekina Lyudmila , Charyeva Gulshirin ,   St. Petersburg State University, Kushnirenko Yaroslav ,   St. Petersburg State University
Published: September 2024

The article presents the pathophysiological features of oxidative stress and the state of the antioxidant system in patients with epilepsy. The issues of lipid peroxidation, its markers, the relationship between oxidative stress, endothelial dysfunction and neuroinflammation, as well as pathomorphological changes in brain tissue in temporal lobe epilepsy and features of neuroplastic processes in these patients are considered. Epileptic seizures can act as a stressor for the body and are accompanied by activation of the hypothalamic-pituitary-adrenal system. The role of cortisol in changes in hippocampal plasticity and distant damage to the hippocampus is considered as a key link in the pathogenesis of cognitive and mental disorders as a result of focal brain lesions. Experimental and clinical data indicate an association between epilepsy and endothelial dysfunction. It has been established that epileptic seizures are accompanied by a long-term loss of the vasodilating function of the cerebral vascular endothelium, leading to a violation of their autoregulation. Data are presented on the possibility of restoring the perfusion of the epileptogenic focus during an attack, which allows some authors to consider them as a compensatory mechanism associated with improved perfusion of brain tissue and the energy status of the cell. The effects of antioxidants in the treatment of epilepsy and the role of comorbid disorders in its course are described. An opinion has been expressed about the prognostic role of oxidative stress markers in the cerebrospinal fluid in the development of pharmacoresistance in epilepsy.