bluuebunny/crossref_metadata_2025 huggingface dataset:
Combined transcriptome and metabolome reveal glutathione metabolism plays a critical role in resistance to salinity in rice landraces HD961
Authors: Yang Shan , Liu Mengshuang , Chu Na , Chen Guanxiu , Wang Panpan , Mo Junjie , Guo Haifeng , Xu Jianghuan , Zhou Hongkai
Published: September 2022

Rice (Oryza sativa) is one of the most important food crops around the world, which is sensitive to salt stress, especially in the seedling and booting stage. HD961 is a salt-tolerant rice landrace that grows along coastal beaches and has disease and insect pest resistance, salt tolerance, and vigorous growth characteristics. We performed a combined transcriptome and metabolome analysis to clarify salinity resistance mechanisms in cultivar HD961, which has adapted to salinity soil at the early seedling stage. The results showed that the growth and antioxidant capacity of HD961 were stronger than 9311 under salt stress (SS). Transcriptomic analysis showed that a total of 6,145, 3,309, 1,819, and 1,296 differentially expressed genes (DEGs) were identified in the groups of TH60 (control group vs. 60 mM group of HD961 for transcriptome), TH120 (control group vs. 120 mM group of HD961 for transcriptome), T60 (control group vs. 60 mM group of 9311 for transcriptome), and T120 (control group vs. 120 mM group of 9311 for transcriptome), respectively. Starch and sucrose metabolism and phenylpropanoid biosynthesis were shared in the four treatment groups based on a KEGG enrichment analysis of DEGs. In addition, alpha-linolenic acid metabolism, plant hormone signal transduction, plant-pathogen interaction, and fatty acid elongation were specific and significantly different in HD961. A total of 92, 158, 151, and 179 significantly regulated metabolites (SRMs) responded to SS in MH60 (control group vs. 60 mM group of HD961 for metabolome), MH120 (control group vs. 120 mM group of HD961 for metabolome), M60 (control group vs. 60 mM group of 9311 for metabolome), and M120 (control group vs. 120 mM group of 9311 for metabolome), respectively. The KEGG analysis showed that eight common metabolic pathways were identified in the four treatment groups, of which biosynthesis of amino acids was the most significant. Three specific metabolic pathways were identified in the HD961, including glutathione metabolism, ascorbate and aldarate metabolism, and pantothenate and CoA biosynthesis. Integrative analysis between the transcriptome and metabolome showed that glutathione metabolism was specific and significantly affected under SS in HD961. A total of seven SRMs and 48 DEGs and four SRMs and 15 DEGs were identified in the glutathione metabolism pathway in HD961 and 9311, respectively. The Pearson correlation analysis showed a significant correlation between reduced glutathione and 16 genes (12 upregulated and four downregulated genes), suggesting these genes could be candidates as salt-tolerance regulation genes. Collectively, our data show that glutathione metabolism plays a critical role in response to SS in rice. Moreover, the stronger regulative ability of related common genes and metabolites might contribute to salt resistance in HD961.
The contribution of the flipped learning environment to value perception and controllability of classroom activities as antecedents of learners’ anxiety: A control-value approach
Authors: Liu Li
Published: September 2022

Students enrolled in tertiary education encounter multiple challenges, which prevent them from being proficient. One of these challenges is anxiety which is a common achievement emotion that impacts many students. Anxiety may prevent learning and may be negatively related to learning due to the negative values of classroom activities and their low controllability. As a result, obtaining more research evidence on anxiety plays an important role in allowing learners to develop the skills they need in different types of technology-based environments such as Flipped Learning (FL). With the prevalence of Internet usage, FL is gaining increasing popularity among higher education individuals. The FL approach is an important model for modifying teaching, cultivating enthusiasm, and interaction, and developing educational presentations in student-focused learning circumstances. The potential affordances of the FL environment might place learners in more positive states of control and value appraisals than the environment of conventional classes, which can lead to the removal of negative emotions such as anxiety. Given the benefits of FL and the potential affordances of its environment, the purpose of this conceptual study is to argue how the inherent affordances of the FL environment can contribute to the controllability and positive values of classroom activities reducing learners’ anxiety in light of control-value theory.
Can resilience promote calling among Chinese nurses in intensive care units during the COVID-19 pandemic? The mediating role of thriving at work and moderating role of ethical leadership
Authors: Sun Tao , Zhang Shu-e , Yin Hong-yan , Li Qing-lin , Li Ye , Li Li , Gao Yu-fang , Huang Xian-hong , Liu Bei
Published: September 2022

Background

Nurses working in the intensive care unit (ICU) clung tenaciously to their job during the COVID-19 pandemic in spite of enduring stressed psychological and physical effects as a result of providing nursing care for the infected patients, which indicates that they possessed a high degree of professionalism and career calling. The aim of this study was to explain the associations between resilience, thriving at work, and ethical leadership influencing the calling of ICU nurses.

Methods

From December 2020 to January 2021 during the COVID-19 pandemic, a cross-sectional survey of 15 provinces in China was conducted using an online questionnaire. A total of 340 ICU nurses (effective response rate: 64.89%) completed sufficient responses to be used in the study. Sociodemographic factors, job demographic factors, resilience, calling, thriving at work, and ethical leadership were assessed using the questionnaire. General linear modeling (GLM), hierarchical linear regression (HLR) analysis, and generalized additive model (GAM) were performed to examine all the considered research hypotheses.

Results

Resilience was positively and significantly associated with calling. Moreover, thriving at work partially mediated the relationship between resilience and calling. The indirect effect of resilience on calling was 0.204 (p < 0.0001), and the direct effect of resilience on calling through thriving at work was 0.215 (p < 0.0001). The total effect of resilience on calling was 0.419 (p < 0.0001). In addition, ethical leadership played a moderating role in the relationship between resilience and calling (β = 0.16, p < 0.05).

Conclusion

Greater resilience can positively predict increased calling among Chinese ICU nurses during the COVID-19 pandemic. Moreover, thriving at work is a mechanism that partly transmits the positive effects of resilience on calling. Overall, nurses possessing greater resilience tend to maintain thriving at work in the face of such adversity, further resulting in subsequently increased calling. Besides, findings suggest that there is stronger influence of resilience on calling among nurses working in an organization managed by an ethical leader. The current findings may offer two insights for nursing practitioners and policymakers in the postpandemic world. First, resilience training and intervention are necessary to foster nurses' sense of thriving at work in the nursing industry, further promoting career calling. Second, better training and effort on the development of ethical leadership for leaders in nursing practice are essential to encourage followers to engage in social learning of ethical behaviors and abiding by normatively appropriate conduct, further enacting prosocial values and expressing moral emotions.
A rowing-specific mindfulness intervention: Effects on mindfulness, flow, reinvestment, and performance
Authors: Sparks Katherine V. , Ring Christopher
Published: September 2022

Mindfulness can benefit athletes’ mindset and performance. These benefits may be enhanced by sport-specific mindfulness interventions. Accordingly, our objectives were 2-fold: first, to develop a rowing-specific mindfulness intervention, and second, to investigate its effects on mindfulness, flow, reinvestment, and rowing performance. Rowers were randomly assigned to either a 6-week rowing-specific mindfulness intervention (n = 23), which included generic and rowing-specific practices, or a control group (n = 21). Rowers completed pre-test and post-test measures of performance, mindfulness, flow, and rowing-specific reinvestment. Lastly, rowers completed an evaluation form following the intervention. The results demonstrated that the intervention group increased flow, mindfulness, and improved performance, additionally conscious motor processing decreased from pre-test to post-test. However, the intervention did not preferentially change mindfulness or reinvestment compared to control. Participants provided favorable feedback and evaluated the intervention positively. Our 6-week rowing-specific mindfulness intervention promoted flow, encouraged mindfulness, and aided performance. Thus, we provide preliminary explorative evidence that a sport-specific mindfulness intervention can benefit athletes. We recommend that future research, with large sample sizes and improved home practice, should examine mediators and moderators of the mindfulness-performance relationship.
Research on the influence mechanism of university-enterprise collaboration: Evidence From five southern coastal provinces in China
Authors: Chen Ximeng , Chen Yan , Li Dongxue , Dong Hao
Published: September 2022

Taking university-enterprise collaborative innovation in five southern coastal provinces of China as subjects, empirical research is implemented by constructing a theoretical model of the effects of interface resource integration, interface conflict management, interface connection mechanisms, and enterprise absorptive capacity on the university-enterprise collaborative innovation performance with the partial least squares structural equation modeling and fuzzy-set qualitative comparative analysis. A total of 245 valid questionnaires were collected from five coastal provinces in south China. The research results show that the interface resource integration, interface connection mechanisms, and enterprise absorptive capacity has direct significant positive impacts on the collaborative innovation performance. Interface conflict management has no significant impact on school-enterprise collaborative innovation performance. Moreover, the interface connection mechanism acts as an intermediary. Therefore, it is suggested that university-enterprise should integrate resources with complementing, interacting, and sharing resources; construct the profit and risk-sharing mechanism, communication and trust mechanism, and organizational learning mechanism.
Automatic morpheme identification across development: Magnetoencephalography (MEG) evidence from fast periodic visual stimulation
Authors: Pescuma Valentina N. , Ktori Maria , Beyersmann Elisabeth , Sowman Paul F. , Castles Anne , Crepaldi Davide
Published: September 2022

The present study combined magnetoencephalography (MEG) recordings with fast periodic visual stimulation (FPVS) to investigate automatic neural responses to morphemes in developing and skilled readers. Native English-speaking children (N = 17, grade 5–6) and adults (N = 28) were presented with rapid streams of base stimuli (6 Hz) interleaved periodically with oddballs (i.e., every fifth item, oddball stimulation frequency: 1.2 Hz). In a manipulation-check condition, tapping into word recognition, oddballs featured familiar words (e.g., roll) embedded in a stream of consonant strings (e.g., ktlq). In the experimental conditions, the contrast between oddball and base stimuli was manipulated in order to probe selective stem and suffix identification in morphologically structured pseudowords (e.g., stem + suffix pseudowords such as softity embedded in nonstem + suffix pseudowords such as trumess). Neural responses at the oddball frequency and harmonics were analyzed at the sensor level using non-parametric cluster-based permutation tests. As expected, results in the manipulation-check condition revealed a word-selective response reflected by a predominantly left-lateralized cluster that emerged over temporal, parietal, and occipital sensors in both children and adults. However, across the experimental conditions, results yielded a differential pattern of oddball responses in developing and skilled readers. Children displayed a significant response that emerged in a mostly central occipital cluster for the condition tracking stem identification in the presence of suffixes (e.g., softity vs. trumess). In contrast, adult participants showed a significant response that emerged in a cluster located in central and left occipital sensors for the condition tracking suffix identification in the presence of stems (e.g., softity vs. stopust). The present results suggest that while the morpheme identification system in Grade 5–6 children is not yet adult-like, it is sufficiently mature to automatically analyze the morphemic structure of novel letter strings. These findings are discussed in the context of theoretical accounts of morphological processing across reading development.
Government’s impression management strategies, trust in government and social cohesion: An evidence from Songjiang University Town, China
Authors: Fan Juan , Liang Wenhui , Zheng Hanyi
Published: September 2022

Trust in government and social cohesion are crucial guarantees for long-term social stability. With the development of the Internet, cross-border flows of information have become increasingly easier, enabling more factors to influence people’s political perceptions and loyalty. This study explores the mechanism of governments’ impression management behaviors on trust in government and social cohesion using the questionnaire survey with college students in Shanghai as the research subjects. Impression management strategies are classified into promotive ones and protective ones herein based on the social psychology theory. The results indicate that both promotive and protective impression management strategies take by governments positively affect citizens’ loyalty, and loyalty positively affects citizens’ social cohesion and the level of trust in government; moreover, the level of trust in government positively affects social cohesion. These findings provide implications for boosting the sound development of China’s political society during the transition period.
What if consciousness is not an emergent property of the brain? Observational and empirical challenges to materialistic models
Authors: Wahbeh Helané , Radin Dean , Cannard Cedric , Delorme Arnaud
Published: September 2022

The nature of consciousness is considered one of science’s most perplexing and persistent mysteries. We all know the subjective experience of consciousness, but where does it arise? What is its purpose? What are its full capacities? The assumption within today’s neuroscience is that all aspects of consciousness arise solely from interactions among neurons in the brain. However, the origin and mechanisms of qualia (i.e., subjective or phenomenological experience) are not understood. David Chalmers coined the term “the hard problem” to describe the difficulties in elucidating the origins of subjectivity from the point of view of reductive materialism. We propose that the hard problem arises because one or more assumptions within a materialistic worldview are either wrong or incomplete. If consciousness entails more than the activity of neurons, then we can contemplate new ways of thinking about the hard problem. This review examines phenomena that apparently contradict the notion that consciousness is exclusively dependent on brain activity, including phenomena where consciousness appears to extend beyond the physical brain and body in both space and time. The mechanisms underlying these “non-local” properties are vaguely suggestive of quantum entanglement in physics, but how such effects might manifest remains highly speculative. The existence of these non-local effects appears to support the proposal that post-materialistic models of consciousness may be required to break the conceptual impasse presented by the hard problem of consciousness.
Efficacy of digital technologies aimed at enhancing emotion regulation skills: Literature review
Authors: Jadhakhan Ferozkhan , Blake Holly , Hett Danielle , Marwaha Steven
Published: September 2022

Background

The impact of emotion regulation (ER) interventions on mental health and wellbeing has been extensively documented in the literature, although only recently have digital technologies been incorporated in intervention design. The aim of this review is to explore available published literature relating to the efficacy, barriers and facilitators of digital technologies in enhancing emotion/mood regulation skills.

Methods

A review of the literature was performed to explore the effectiveness of digital technology in enhancing ER skills. MEDLINE, CINAHL, PsycINFO and Web of Science databases were searched from inception to 31st August 2020. In addition, the first 10 pages of Google Scholar were examined for relevant articles. The following MeSH term and key words were used to identify relevant articles: “emotion regulation OR mood regulation” AND “intervention OR treatment OR program$ OR therap$” AND “digital technologies OR web-based OR mobile application OR App.” Reference lists of retrieved papers were hand searched to identify additional publications. Findings were summarized narratively.

Results

Titles and abstracts were reviewed by one reviewer in two phases, and confirmed by a second reviewer; discrepancies were resolved through discussion. First, the retrieved titles and abstracts were reviewed to identify relevant studies. Full texts of retrieved studies were then read to determine eligibility. The search resulted in 209 studies of which 191 citations were identified as potentially meeting the inclusion criteria. After reviewing the title and abstract of the 191 papers, 33 studies were identified as potentially meeting the inclusion criteria. Following full-text review, 10 studies met the inclusion criteria. Findings indicated the potential effectiveness of online, text-messaging, and smartphone interventions for enhancing ER skills.

Conclusion

There is encouraging evidence that digital technologies may be beneficial for enhancing ER skills and providing personalized care remotely. Digital technologies, particularly the use of smartphones, were instrumental in facilitating assessments and delivering online self-help interventions such as cognitive behavioral therapy. Continued research is required to rigorously evaluate the effectiveness of digital technologies in ER skills and carefully consider risks/benefits while determining how emerging technologies might support the scale-up of ER skills and mental health treatment.
The efficacy and safety of Jin's three-needle therapy vs. placebo acupuncture on anxiety symptoms in patients with post-stroke anxiety: A study protocol for a randomized controlled trial
Authors: Li Meichen , Wang Yuting , Li Keyi , Xu Xiaoyan , Zhuang Lixing
Published: September 2022

Background

A large number of clinical RCTs have verified that Jin's three-needle therapy (JTNT) has a great contribution to promoting the function of paralyzed limbs and relieving anxiety disorders for patients with post-stroke anxiety (PSA). However, there is still a lack of sham needle control, and its placebo effect cannot be ruled out. This study firstly verifies the real effectiveness of JTNT. Besides, the changes in serum indexes on the hypothalamic-pituitary-adrenal axis (HPA axis) are observed dynamically by the Enzyme-Linked ImmunoSorbent Assay (ELISA). The activation of different brain regions by JTNT is recorded using resting functional magnetic resonance imaging (rs-fMRI). Therefore, we can provide more practical and powerful evidence-based medical evidence for clinical decisions.

Method

This is a 16 week parallel, single-blind, random, controlled trial, including baseline, 4 weeks of treatment, and 12 weeks of follow-up. A total of 114 participants will be randomly divided into three groups in the proportion of 1:1:1. Participants will receive Jin's three-needle therapy in the active acupuncture group and accept sham needle treatment in the sham acupuncture group. In the waitlist control group, patients will not receive any acupuncture treatment. Outcomes cover three types of indicators, including scale indicators, serum indicators, and imaging indicators. The primary outcome is the change in the performance of anxiety symptoms, which is estimated by the 14-item Hamilton Anxiety Rating Scale (HAMA-14) and the 7-item Generalized Anxiety Disorder scale (GAD-7). Secondary outcomes are physical recovery and daily quality of life, which are evaluated by the National Institute of Health stroke scale (NIHSS) and the Modified Barthel Index Score (MBI Scale). Therefore, the assessment of the scale is carried out at baseline, 2nd, 4th, 8, 12, and 16 weeks. Adrenocorticotropin and cortisol will be quantitatively detected by ELISA at baseline and 4 weeks after treatment. In addition, regional homogeneity analysis (ReHo) will be used to record the activity of brain regions at baseline and 4 weeks after intervention.

Discussion

The study aims to provide high-quality clinical evidence on the effectiveness and safety of JTNT for patients with PSA. In addition, this trial explores a possible mechanism of JTNT for patients with PSA.

Clinical trial registration

Chinese Clinical Trial Registry, identifier [ChiCTR2200058992].
Impulsivity trait mediates the relationship between white matter integrity of prefrontal–striatal circuits and the severity of dependence in alcoholism
Authors: Wu Fei , Dong Ping , Wu Guowei , Deng Jiahui , Ni Zhaojun , Gao Xuejiao , Li Peng , Li Bing , Yuan Junliang , Sun Hongqiang
Published: September 2022

Background

Alcohol dependence (AD) remains one of the major public health concerns. Impulsivity plays a central role in the transfer from recreational alcohol use to dependence and relapse. White matter dysfunction has been implicated in alcohol addiction behaviors and impulsivity. However, little is known about the role of systematic striatal structural connections underlying the mechanism of impulsive traits in AD.

Methods

In our study, we used seed-based classification by probabilistic tractography with five target masks of striatal circuits to explore the differences in white matter integrity (fractional anisotropy, FA) in AD male patients (N = 51) and healthy controls (N = 27). We mainly explored the correlation between FA of the striatal circuits and impulsive traits (Barratt Impulsiveness Scale, BIS-11), and the mediation role of impulsivity in white matter integrity and the severity of alcohol dependence.

Results

Compared with healthy controls, AD showed much lower FA in the left and right striatum–supplementary motor area (SMA) and left striatum–amygdala. We also found the decreased FA of right striatum-vlPFC was correlated with higher impulsivity. Besides, the relationship between reduced FA of right striatum-vlPFC and severity of dependence could be mediated by impulsivity.

Conclusion

In our study, we found disrupted white matter integrity in systematic striatal circuits in AD and the decreased FA of right striatum-vlPFC was correlated with higher impulsivity in AD. Our main findings provide evidence for reduced white matter integrity of systematic striatal circuits and the underlying mechanisms of impulsivity in male AD individuals.
Combined probiotics attenuate chronic unpredictable mild stress-induced depressive-like and anxiety-like behaviors in rats
Authors: Huang Li , Lv Xia , Ze Xiaolei , Ma Zewei , Zhang Xuguang , He Ruikun , Fan Junting , Zhang Meilin , Sun Boran , Wang Fang , Liu Huan
Published: September 2022

Increasing evidence indicated that probiotics can be effective in improving behaviors similar to depression and anxiety disorders. However, the underlying mechanisms remain unclear, as is the effects of single vs. combined probiotics on depression and anxiety. This study aimed to determine whether combined probiotics could attenuate depressive-like and anxiety-like behavior induced by chronic unpredictable mild stress (CUMS) and its potential mechanisms. Rats underwent CUMS treatment and then administered Lactobacillus rhamnosus HN001 (HN001) or Bifidobacterium animalis subsp. lactis HN019 (HN019), alone or in combination. Levels of neurotransmitters, inflammatory factors, and the gut microbiota were measured. HN001 and (or) HN019 treatment improved depressive-like and anxiety-like behavior in rats, including increased moving distance and exploratory behavior (p < 0.05). In addition, altered gut microbiota structure induced by CUMS was amended by HN001 and/or HN019 (p < 0.05). HN001 and/or HN019 intervention also remarkably normalized levels of 5-HT, DA, NE, HVA, DOPAC, HIAA, TNF-α, IL-6, IL-18 and IL-1β in CUMS rats (p < 0.05). Furthermore, the effects of combined probiotics on decreasing inflammation and improved gut microbiota (Chao1 index and ACE index, p < 0.05) were superior to the single probiotics. Moreover, spearman analysis showed a certain correlation between the different microbiota, such as Firmicutes, Bacteroidetes, Verrucomicrobias, Proteobacterias and Actinobacterias, and inflammation and neurotransmitters. These findings suggested that CUMS induced depressive and anxiety-like behaviors can be alleviated by the combination of probiotics, which was possibly associated with the alterations in the gut microbiota composition and increased neurotransmitters and decreased inflammatory factors.
Health Behaviors and Associated Feelings of Remote Workers During the COVID-19 Pandemic—Silesia (Poland)
Authors: Białek-Dratwa Agnieszka , Szczepańska Elżbieta , Grajek Mateusz , Całyniuk Beata , Staśkiewicz Wiktoria
Published: September 2022

During the COVID pandemic in Poland, lockdown and remote work affected a very large segment of the population. This situation has many negative consequences both in terms of health and also emotionally. In our study, we focused on eating behaviors as well as health behaviors such as alcohol consumption, smoking, physical activity while working remotely, but also the emotions that occur while being at home working for long periods of time and how these emotions affect diet, eating behaviors and overall well-being using the standardized WHO-5 and TFEQ13 questionnaires. Surveys completed by 225 individuals doing remote work from home or hybrid work. During lockdown and remote work, 64.4% people noticed changes in eating behaviors: of which 44.0% people eat more than before lockdown, while 20.0% eat less than before; 36.0% believe they did not notice a change regarding the amount of food consumed. Changes in eating behavior did not correlate with body weight (p = 0.37), but did correlate with changes in body weight (p = 0.00000). Body weight correlated with changes in body weight that occurred in the study group during lockdown (p = 0.000004). Individuals who restrict eating according to TFEQ 13 are more likely to report well-being (WHO-%), whereas individuals who are observed to lack control over eating and eat under emotional duress are more likely to report poor well-being (p = 0.000000). The study confirmed the change in dietary behavior and the occurrence of adverse health eating behaviors among remote and hybrid workers during the COVID-19 pandemic.
Potential ecological risk assessment of heavy metals (trace elements) in coastal soils of southwest Iran
Authors: Hamid Ebtessam , Payandeh Khoshnaz , Karimi Nezhad Mohammad Tahsin , Saadati Naghmeh
Published: September 2022

Heavy metal pollution has become one of the most important threats that can endanger the health of animals, the environment, and humans. The present study was performed to investigate the potential ecological risk (PER) of heavy metals [zinc (Zn), copper (Cu), cobalt (Co), molybdenum (Mo), manganese (Mn), and selenium (Se)] in the coastal soils of southwest Iran in 2019. The samples were collected from six soil sites and three depth intervals (0–15, 15–30, and 30–45 cm) among bare and vegetated coastal soils. The soil samples to study the soil properties (soil grain size, pH, EC, and soil organic carbon) and metal contamination were taken from soil (36 samples), water (6 samples), and plants (24 samples). The soil ecological risk (ER), the pollution load index (PLI), contamination degree (Cdeg), modified contamination degree (mCdeg) for heavy metal contamination in the soil, and enrichment factor (EF index) indicate the origin of metals entering the environment, and hence these parameters were investigated. The results of this study showed that the levels of Zn, Cu, Co, Mn, Se, and Mo were in the range of low-risk contaminants in this region. According to the results of the study, the risk index (RI) for metals was in the range of 1.296–3.845, which is much lower than 150, and therefore the ecological risk potential calculated in this study was in the low-risk category for toxic elements. Based on the results, it was found that agricultural, industrial, and human activities played an effective role in the accumulation of Zn, Cu, Co, Se, and Mo in the soil. In addition, the main source of Mn metal is believed to be natural due to geological activities in the region.
Economic evaluation of first-line nivolumab plus cabozantinib for advanced renal cell carcinoma in China
Authors: Wang Hao , Wang Ye , Li Li , Zhou Han , Lili Shang , Li Liao , Yike Shen , Aixia Ma
Published: September 2022

Background

In the Checkmate9ER trial, first-line treatment with nivolumab combined with cabozantinib (NI + CA) has shown efficacy for advanced renal cell carcinoma. This study aims to evaluate the impact of the health and economic outcomes of NI + CA in China.

Methods

Clinical efficacy data were derived from pivotal phase III CheckMate 9ER trial. A three-state partitioned survival model was established based on disease progression. Progression-free survival and overall survival of NI + CA vs. sunitinib were fitted with log-logistic and log-normal distributions, respectively. Mixture cure, non-mixture cure, and Royston/Parmar spline models were used to evaluate model robustness. The results derived the computational cost from the Chinese healthcare system perspective. The primary outcomes were quality-adjusted life-years (QALYs), total cost in US dollars, as well as incremental cost-effectiveness ratios (ICERs) at the willingness-to-pay threshold in China. One-way and probabilistic sensitivity analysis were also used to assess the robustness of the model.

Results

In the base-case analysis result, 0.86 additional QALYs could be obtained in the NI+CA (3.84 QALYs) versus the sunitinib strategy (2.97 QALYs). The ICER of NI+CA compared with the sunitinib strategy was US$292,945 per QALY. The ICER value in the NI+CA strategy was higher than the Chinese willingness-to-pay threshold of US$38,024 per QALY. Although NI+CA can improve long-term patient survival significantly over sunitinib in the treatment of advanced renal cell carcinoma, it is unlikely to be cost-effective due to high cost. The results of the one-way sensitivity analysis showed that drug cost, health utility value at the stage of disease progression, and subsequent treatment proportion had a greater impact on the stability of ICER values.

Conclusions

Nivolumab combined with cabozantinib can prolong the life of patients with advanced renal cell carcinoma and improve their quality of life, but there is a corresponding increase in medical cost. The NI + CA strategy is unlikely to be considered cost-effective in the treatment of advanced RCC from the perspective of Chinese healthcare system.
Depression and anxiety of medical students at Kunming Medical University during COVID-19: A cross-sectional survey
Authors: Guo Ying , Li Shunda , Zhang Lanchun , Xuan Qun , He Liu , Ye Qingyan , Ma Jiaqing , Peng Li , Xiong Yunxia , Yang Jianyu , Yu Haofei , Xie Jianping , Shao Heng , Yuan Yun
Published: September 2022

An isolation strategy was used to control the transmission and rapid spread of COVID-19 in Yunnan. As a result, students were supposed to stay at home and disrupted their outside activities. It led to a detrimental influence on students' mental health. The purpose of this study was to investigate the prevalence and risk factors of depression and anxiety among medical students and to provide ideas for the prevention of depression and anxiety in medical students. A cross-sectional survey was conducted among 2,116 medical students at Kunming Medical University from July 8 to July 16, 2020. Participants' demographic and living conditions were collected. Depression and anxiety were measured using the Patient Health Questionnaire 9 and General Anxiety Disorder-7, respectively. Uni- and multivariate logistic regression analyses were performed to detect risk factors associated with depression and anxiety. The prevalence rates of depression and anxiety among medical students were 52.5 and 29.6%, respectively. Depression was more likely to be caused by low grades, lack of physical exercise, drug use, irregular diet, extensive screen time on mobile phones, being greatly affected by the COVID-19 pandemic, and inadaptability to offline courses. Anxiety was more likely to be caused by lack of physical exercise, drug use, irregular diet, and inadaptability to offline courses. Depression and anxiety are highly comorbid. Our study showed predictive factors for depression and anxiety and identified a major mental health burden on medical students during the COVID-19 outbreak. More targeted measures should be taken to improve the mental state of students to reduce the incidence of depression and anxiety.
Investigation of the relationship between incidence of mental disorders and economic growth among the Visegrad countries
Authors: Szőllősi Gergő József , Boruzs Klára , Karcagi-Kováts Andrea , Kalas Nándor , Bányai Gábor , Bíró Klára
Published: September 2022

Prevention and care for mental disorders represent an important public health task in achieving global development goals. Proper access to adequate healthcare and social services is an important step related to care for mental disorders, which is presumably strongly related to economic growth. The main aim of the study was to investigate the relationship between the economic growth and the incidence of mental disorders in the V4 countries. An ecological correlation study was conducted regarding the four Visegrad countries. Indicators were derived from the World Health Organization (WHO) ‘Health for All' (HFA) online database and Penn World Table version 10. The incidence of mental disorders increased in the V4 countries throughout the years between 2000–2018 except in Hungary, where a decreasing trend was observed. The prevalence of mental disorders increased in all countries as well, but it stagnated in Hungary. At the same time standardized death rate due to mental disorders increased in all Visegrad countries. According to the Hungarian data, while the prevalence of the disease did not change remarkably, the incidence decreased and the mortality increased as well as the prescription of drugs used in the treatment of mental disorders. This could indicate a serious hidden morbidity.
Walking on paintings: Assessment of passive haptic feedback to enhance the immersive experience
Authors: Ziat Mounia , Jhunjhunwala Rishi , Clepper Gina , Kivelson Pamela Davis , Tan Hong Z.
Published: September 2022

Virtual reality has been used in recent years for artistic expression and as a tool to engage visitors by creating immersive experiences. Most of these immersive installations incorporate visuals and sounds to enhance the user’s interaction with the artistic pieces. Very few, however, involve physical or haptic interaction. This paper investigates virtual walking on paintings using passive haptics. More specifically we combined vibrations and ultrasound technology on the feet using four different configurations to evaluate users’ immersion while they are virtually walking on paintings that transform into 3D landscapes. Results show that participants with higher immersive tendencies experienced the virtual walking by reporting illusory movement of their body regardless the haptic configuration used.
Backward-propagating source as a component of rising tone whistler-mode chorus generation
Authors: Harid Vijay , Gołkowski Mark , Hosseini Poorya , Kim Hoyoung
Published: September 2022

Whistler-mode chorus waves in the magnetosphere play a crucial role in space weather via wave–particle interactions. The past two decades have observed tremendous advances in theory and simulations of chorus generation; however, several details of the generation mechanism are still actively contended. To simulate chorus generation, a new envelope particle-in-cell code is introduced. The model produces a rising tone chorus element in a parabolic geomagnetic field. The initial chorus element “embryo” frequency is shown to initialize near the equator at the frequency of maximum linear growth. A backward resonant current is then observed to propagate upstream of the equator. The trajectory of the backward current follows that of a freely falling electron that has been de-trapped at the equator superimposed with forward motion at the group velocity. The backward current iteratively radiates a rising tone element where the highest frequency components are generated furthest upstream. The work provides new advancements in modeling chorus and corroborates other recent work that has also demonstrated a backward-moving source during the generation of coherent whistler-mode waves.
Anti-browning effects of citronellal on fresh-cut taro (Colocasia esculenta) slices under cold storage condition
Authors: Wang Bin , Wang Yukun , Huang Yongyan , Jiang Yuanyuan , He Jinming , Xiao Yanhui
Published: September 2022

The browning on the cut surface is a big problem reducing the quality of fresh-cut taro (FCT), which causes severe postharvest losses and may raise environmental impacts. Citronellal (CA) is a natural compound in several aromatic plants. This study investigated the effects of CA treatments in different concentrations (0.2, 0.5, and 1 mL/L) on the browning of FCT under cold storage at 5°C. The results indicated that low-dose (0.2 mL/L) CA treatment showed best anti-browning effects, reflecting at the maintained L* values but the reduced a*, b* and browning index values by CA treatment during cold storage. A repeated experiment using 0.2 mL/L CA confirmed fine anti-browning effects again. Furthermore, CA (0.2 mL/L) treatment markedly reduced the contents of total phenolic compounds and soluble quinones, restrained the activities of phenylalanine ammonia lyase, peroxidase and polyphenol oxidase, down-regulated the gene expression of 18 browning-related enzymes in FCT. These results together strongly demonstrate the validity of CA on FCT browning prevention. Given that CA is a natural compound existing in plants, low concentration of CA possesses strong anti-browning effects on FCT and also inhibitory effects on pathogens, implying that its application has potentiality to preserve high quality of fresh-cut produce for processing and storage. Moreover, CA treatment significantly decreased malondialdehyde contents and lipoxygenase activity. Correlation analysis indicated that the lipid peroxidation of cell membrane was mostly correlated with FCT browning. The results suggest that membrane lipid peroxidation was a possible reason for FCT browning and CA treatment reduced browning, in part, through alleviating the lipid peroxidation of cell membrane. Overall, our results demonstrate that CA is a novel browning mitigator for FCT under cold storage condition.
Mapping knowledge structure and themes trends in unilateral biportal endoscopic spine surgery: A bibliometric analysis
Authors: Zhu Ming-Tao , Li Kunrong , Hu Bao-Shan , Chen Chien-Min , Lin Guang-Xun
Published: September 2022

Background

The numerous benefits of unilateral biportal endoscopic (UBE) spine surgery have attracted the attention of many researchers, and a considerable number of relevant clinical studies have been published. However, global research trends in the field of UBE have received little attention. The purpose of this study was to apply bibliometric method to analyze the UBE-related publications to obtain an overview of the research trends in the field of UBE, as well as research hotspots and trends.

Methods

Web of Science database was searched for articles published until January 31, 2022. CiteSpace was used to analyze the data, which provided graphical knowledge maps. The following factors were applied to all literature: number of publications, distribution, h-index, institutions, journals, authors, and keywords.

Results

Seventy-three articles were identified. Since 2019, there has been a significant increase in the number of UBE-related publications. The country with the largest number of articles was South Korea (72.6%), followed by China (9.6%), Japan (4.1%), and Egypt (4.1%). South Korea had the highest h-index (16), followed by China (2), Japan (1), and Egypt (1). Leon Wiltse Memorial Hospital was the organization that produced the most papers (12 publications). Heo DH was the most productive author (16 papers) and was the most cited author (35 times). World Neurosurgery published the most papers on UBE (23.3%). The main research hotspots were spinal diseases, decompression, complications, learning curve, and interbody fusion. In addition, the recent concerns were “learning curve,” “interbody fusion,” “management,” and “dural tear.”

Conclusions

The quantity of publications on UBE research will increase, and South Korea being the major contributor and most prominent country in this field. The findings of our study will provide researchers with practical information on the field of UBE, and identification of mainstream research directions and recent hotspots.
Case report: Type I diastematomyelia with breast abnormalities and clubfoot
Authors: Hao Shenshen , Yue Zenan , Yu Xin , Gao Zhenfu , Li Hongke , Liu Shuai , Dong Shengli
Published: September 2022

Background

Diastematomyelia is a rare congenital spinal cord malformation, classified as type I or type II, with over half of the cases considered type I. However, type I diastematomyelia with breast abnormality and clubfoot is extremely rare in clinical practice.

Case presentation

We admitted an 18-year-old female patient with type I diastematomyelia with breast abnormalities and clubfoot. She was underwent surgical treatment. After the surgical removal of the pressure-causing bone spur, the weakness of the right lower limb was significantly relieved. During the 22-month follow-up, there was no complication and no recurrence.

Conclusion

Surgical removal of the pressure-causing bone spur can relieve symptoms in the lower limbs. However, further research is warranted to explore the breast abnormalities in patients with diastematomyelia.
Rapid risk assessment tool (RRAT) to prioritize emerging and re-emerging livestock diseases for risk management
Authors: de Vos Clazien J. , Petie Ronald , van Klink Ed G. M. , Swanenburg Manon
Published: September 2022

Increasing globalization and international trade contribute to rapid expansion of animal and human diseases. Hence, preparedness is warranted to prevent outbreaks of emerging and re-emerging diseases or detect outbreaks in an early stage. We developed a rapid risk assessment tool (RRAT) to inform risk managers on the incursion risk of multiple livestock diseases, about the main sources for incursion and the change of risk over time. RRAT was built as a relational database to link data on disease outbreaks worldwide, on introduction routes and on disease-specific parameters. The tool was parameterized to assess the incursion risk of 10 livestock diseases for the Netherlands by three introduction routes: legal trade in live animals, legal trade of animal products, and animal products illegally carried by air travelers. RRAT calculates a semi-quantitative risk score for the incursion risk of each disease, the results of which allow for prioritization. Results based on the years 2016-2018 indicated that the legal introduction routes had the highest incursion risk for bovine tuberculosis, whereas the illegal route posed the highest risk for classical swine fever. The overall incursion risk via the illegal route was lower than via the legal routes. The incursion risk of African swine fever increased over the period considered, whereas the risk of equine infectious anemia decreased. The variation in the incursion risk over time illustrates the need to update the risk estimates on a regular basis. RRAT has been designed such that the risk assessment can be automatically updated when new data becomes available. For diseases with high-risk scores, model results can be analyzed in more detail to see which countries and trade flows contribute most to the risk, the results of which can be used to design risk-based surveillance. RRAT thus provides a multitude of information to evaluate the incursion risk of livestock diseases at different levels of detail. To give risk managers access to all results of RRAT, an online visualization tool was built.
Federated Optimization of ℓ0-norm Regularized Sparse Learning
Authors: Tong Qianqian , Liang Guannan , Ding Jiahao , Zhu Tan , Pan Miao , Bi Jinbo
Published: September 2022

Regularized sparse learning with the ℓ0-norm is important in many areas, including statistical learning and signal processing. Iterative hard thresholding (IHT) methods are the state-of-the-art for nonconvex-constrained sparse learning due to their capability of recovering true support and scalability with large datasets. The current theoretical analysis of IHT assumes the use of centralized IID data. In realistic large-scale scenarios, however, data are distributed, seldom IID, and private to edge computing devices at the local level. Consequently, it is required to study the property of IHT in a federated environment, where local devices update the sparse model individually and communicate with a central server for aggregation infrequently without sharing local data. In this paper, we propose the first group of federated IHT methods: Federated Hard Thresholding (Fed-HT) and Federated Iterative Hard Thresholding (FedIter-HT) with theoretical guarantees. We prove that both algorithms have a linear convergence rate and guarantee for recovering the optimal sparse estimator, which is comparable to classic IHT methods, but with decentralized, non-IID, and unbalanced data. Empirical results demonstrate that the Fed-HT and FedIter-HT outperform their competitor—a distributed IHT, in terms of reducing objective values with fewer communication rounds and bandwidth requirements.