bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards effective administration and supervision of technical and vocational education in Nigeria
Authors: Obayi Anthony , Nwosu Rose Yeyeda , Hamzat Abisola Esther
Published: September 2024

The world all over is of the opinion that quality and functional education is a pre requisite for the attainment of a country's development economically and technologically. Monumental studies and achievements in various spheres of life by developed and developing Nations of the world are often attributed to products of high standards of education. The efficacy and efficiency of educational system lies in its ability to deliver quality education in cost effective ways, For such educational system to stand tall in attaining these goals, reinvigorated or repositioned administrative and supervisory functions in all our educational systems in general and vocational and technical education in particular must be put in place. This paper focuses on the administration and supervision of technical and vocational education. It observes the challenges to effective administration and supervision of technical and vocational education. Far-reaching recommendations are proffered to address these challenges.
Tinjauan Hukum Islam Terhadap Merarik Nyongkolan (Study Kasus di Desa Bajur Kec. Labuapi Lobar)
Authors: Badarudin
Published: September 2024

This study examines the Merarik Nyongkolan tradition in the Sasak community of Bajur Village, Labuapi District, West Lombok, from an Islamic legal perspective. The tradition, which involves the "elopement" of the bride and a Nyongkolan procession, has often been questioned regarding its conformity with Islamic law. The research utilizes a qualitative method with a descriptive-analytical approach. Data were collected through in-depth interviews with community leaders, religious scholars, and married couples and direct observation of the Nyongkolan procession. The findings reveal that while most of the community supports the preservation of this tradition, debates arise concerning certain elements that are perceived as inconsistent with Islamic principles, such as the "elopement" of the bride and the public, festive parades. The contribution of this research lies in its in-depth explanation of how the Sasak community strives to balance the preservation of local culture with adherence to Islamic law. It also recommends adapting the tradition to align more closely with religious values without losing its cultural identity.
Rethinking Leadership Development for the 21st Century: C-Suite Perspectives on Change, Talent, and Representation
Authors: Westover Jonathan
Published: September 2024

Abstract: This article examines organizational perspectives on bridging leadership development gaps in three key areas: change management, talent development, and diversity/inclusion. Executive surveys find that while disruptive change preparedness is a top priority, leadership programs often fail to adequately develop adaptability. To close this gap, companies emphasize developing agility, experimentation, and change-ready cultures. For talent development, identification must leverage broader strengths over past roles. Emerging leaders benefit from diverse mobility experiences through rotations and global assignments. Regarding diversity, representation is viewed as more than a social responsibility but a business imperative for accessing varied perspectives. Leaders recommend making inclusion central to mission/strategy and reevaluating sponsoring and sourcing approaches to give minority talent fair opportunities. Overall, holistically developing adaptive, diverse leaders through experiential learning better positions organizations to navigate complexity.
Theories of Meaning and Value in Action
Authors: Heinzman J. Robert
Published: September 2024

The research presents ideas which identify valued derivation from several theories in various philosophical schools of thought. This discussion of theories, like core and changing values of traditional philosophical realm, rationalism, idealism, empiricism, and pragmatism from the modern era, and existentialism, deconstructionism, social constructionism, and phenomenology from the postmodern area of thought, and appreciative environment, identify value theory and apply these theoretical premises too personal and workplace settings, offering recommendations where applicable.
Robbing Students of Future Earnings and America’s Economic Growth: The Lack of Financial Literacy Courses in Public Schools
Authors: Medin Abigail
Published: September 2024

This study evaluates the benefits and opportunities of a high school financial literacy course mandate. Growing American credit card debt and personal bankruptcies have demonstrated a need for financial literacy. This knowledge would empower individuals to have better credit management and budgeting practices, more favorable loans/interest rates, and the ability to grow their wealth. An analysis of interest rate distribution, financial literacy surveys, and the success of other financial education methods have shown the potential return and benefits in the long run for high school graduates of just a single semester course. Data from the Brooking Institute and Harvard Business School has proven that financial education taught at a younger age results in greater economic stability. Therefore, students who take a personal finance course will be less reliant on welfare programs and contribute more to society. With the apparent financial disparities in education and wealth across many groups, high school presents a unique opportunity to address most students before their paths diverge effectively.
Tingkat Kepuasan Konsumen Pada Pelayanan Resep di Apotek Kimia Farma 189 Mataram Periode Februari 2022
Authors: Arisanthi Luh Citra , Hasina Raisya , Puspitasari Candra Eka
Published: September 2024

Apotek adalah tempat praktik pelayanan kefarmasian oleh Apoteker. Pelayanan kefarmasian yang diberikan dapat berpengaruh terhadap kepuasan konsumen sehingga berdampak pada minat berkunjung kembali. Kepuasan konsumen merupakan indikator penilaian baik atau buruknya pelayanan yang diberikan kepada konsumen. Penelitian ini bertujuan untuk mengetahui tingkat kepuasan konsumen pada pelayanan resep di apotek Kimia Farma 189 Mataram. Penelitian ini bersifat deskriptif dengan rancangan cross-sectional. Teknik pengambilan sampel yang digunakan adalah purposive sampling dimana diperoleh sebanyak 115 responden yang terdiri dari 55% laki-laki dan 60% perempuan. Instrumen penelitian yang digunakan adalah service quality yang telah diuji validitas dan reliabilitas dimana diperoleh nilai r hitung pada rentang 0,605-0,908 dan nilai Cronbach alpha sebesar 0,968. Responden pada penelitian ini didominasi oleh kelompok umur 31-50 tahun (43,5%) yang merupakan pelanggan, dimana dilihat dari jumlah kedatangan lebih dari 5 kali (59,1%) dan tujuan penebusan resep didominasi untuk anak atau keluarga (59,1%). Pada penelitian ini juga didominasi oleh responden yang sudah menikah (72,2%) sehingga angka Ibu rumah tangga (17,4%) juga mendominasi dan responden yang tidak berpenghasilan (33,9%). Apotek ini telah bekerja sama sejak 2001 dengan BPJS Kesehatan sehingga responden didominasi oleh metode pembayaran dengan BPJS Kesehatan (93%). Berdasarkan instrument service quality diperoleh tingkat kepuasan konsumen pada setiap dimensi pelayanan antara lain jaminan (84%), ketanggapan (82%), kepedulian (82%), fasilitas fisik (82%) dan kehandalan (80%) sehingga dapat disimpulkan bahwa tingkat kepuasan konsumen pada pelayanan resep pada dimensi pelayanan jasa adalah sangat puas kecuali dimensi kehandalan (puas)
Analisis Perbandingan Swamedikasi Pada Masyarakat Di Desa Kadumaneuh Dan Desa Cikeusik
Authors: Yusransyah Yusransyah , Insani Nurul , Masfuah Imas , Bahaudin Bahaudin
Published: September 2024

Tingginya presentase swamedikasi menjadi salah satu penyebab munculnya kesalahan pengobatan. Pengetahuan yang cukup diharapkan menimbulkan sikap yang positif dan memaksimalkan kewaspadaan agar tidak terjadi gangguan kesehatan. Penelitian ini bertujuan untuk mengetahui perbandingan tingkat pengetahuan dan sikap antara Desa Kadumaneuh dan Desa Cikeusik, serta menganalisis hubungan tingkat pengetahuan terkait swamedikasi dengan faktor sosiodemografi dan sikap. Penelitian ini menggunakan metode kuantitatif pendekatan cross sectional dengan jumlah sampel 100 orang responden. Teknik pengambilan sampel menggunakan purposive sampling, sedangkan pengambilan data dilakukan dengan kuesioner. Data dianalisis dengan menggunakan analisis univariat, Chi Square, Mann Whitney dan Rank Spearman. Hasil penelitian menunjukan bahwa tidak terdapat perbedaan tingkat pengetahuan antara Desa Kadumaneuh dan Desa Cikeusik dan mayoritas responden di kedua desa tersebut mempunyai kriteria sikap negatif terhadap swamedikasi. Hasil penelitian terkait hubungan faktor sosiodemografi dengan tingkat pengetahuan, yang mempunyai hubungan signifikan yaitu pendidikan terakhir (P<0,05), sedangkan faktor sosiodemografi yang lain (jenis kelamin, usia, pekerjaan, pendapatan dan status perkawinan) tidak mempunyai hubungan yang signifikan (P>0,05). Hasil hubungan antara sikap dengan tingkat pengetahuan yaitu tidak mempunyai hubungan yang signifikan (P>0,05).
Formulation And Physical Stability Test Of Facial Wash Gel Ethanol Extract Of White Frangipani Plumeria Alba Flower (Plumeria Alba) With Hidroxy Propyl Methyl Cellulose (Hpmc) As Gelling Agent
Authors: Amirah Hilda Amirah
Published: September 2024

White Cambodian flower (Plumeria alba) contains secondary metabolite compounds in the form of flavonoids, tannins, alkaloids, and saponins. The purpose of this study was to determine whether the 96% ethanol extract of the white frangipani flower (Plueria lba) could be formulated into a facial wash gel preparation formulated with HPMC base in terms of stability. White frangipani flowers were extracted by maceration method with 96% ethanol solvent ratio 1:4. The facial wash gel of white frangipani  flower extract was made into 4 formulations with different concentrations, namely 0%, 1%, 2%, and 2.5%. The facial wash gel formulation was then evaluated for its physical stability using the Freez thaw cycling method and hedonic and irritation tests were carried out on 10 respondents. The results showed that differences in the concentration of white frangipani flower extract could affect physical stability, respondents' interest and irritation. Good physical stability test results are found in the F1 and F2 formulations where the pH, foam height, organoleptic and homogeneity tests have met the requirements for facial wash gel preparations but in the dispersion test they do not meet the requirements. while for the interest of respondents, a good formulation is the F2 formulation.
Studi Penambatan Molekul Senyawa Turunan Kurkuminoid Terhadap Enzim Penicillin Binding Protein 2A Pada Bakteri MRSA
Authors: Mulki Irpani Abdul , Indra Dinata Deden
Published: September 2024

Methicillin-resistant Staphylococcus aureus (MRSA) merupakan bakteri yang resisten terhadap antibiotik ?-laktam seperti methicillin, merupakan masalah klinis yang terus-menerus mempengaruhi seluruh dunia. Resistensi terjadi akibat adanya modifikasi struktural Penicillin Binding Protein pengikat penisilin (PBP) MRSA. Senyawa aktif organik dengan sifat antibakteri telah memicu minat masyarakat salah satunya adalah kurkumin yang diketahui memiliki potensi antibakteri yang kuat dan dapat merusak membran bakteri. Tujuan dari penelitian ini untuk mengetahui senyawa turunan kurkuminoid yang berpotensi sebagai calon obat antibakteri MRSA dengan studi in silico menggunakan metode molecular docking. Hasil yang didapatkan senyawa kurkumin memiliki energi bebas ikatan -5,56 kcal/mol, demetoksi kurkumin -6,25 kcal/mol dan bisdemetoksi kurkumin -6,24 kcal/mol. Interaksi yang terbentuk menunjukkan afinitas pengikatan, dari data yang didapatkan semua ligan memilki afinitas yang baik meskipun nilai energi bebas ikatan lebih rendah dibandingkan ligan alami.
Uji Aktivitas Antioksidan Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) Yang Diformulasikan Kedalam Sediaan Masker Gel
Authors: Zaelani Diki , Pratama Reza , Japar Sodik Jajang , Hilda Restu Afria
Published: September 2024

Penelitian ini menggunakan buah mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.) sebagai zat aktif dalam pembuatan masker gel, mengingat penggunaannya yang luas sebagai obat dan kandungan antioksidannya yang dapat menghambat radikal bebas. Penelitian diawali dengan pengumpulan buah dari kebun percobaan di Lembang-Bandung dan diidentifikasi sebagai Phaleria macrocarpa (Scheff.) Boerl. Ekstraksi dilakukan dengan metode maserasi menggunakan etanol 96% selama 3x24 jam. Hasil skrining fitokimia menunjukkan bahwa ekstrak positif mengandung alkaloid, flavonoid, tanin, triterpenoid, dan steroid. Aktivitas antioksidan masker gel diuji dengan metode perendaman DPPH, menghasilkan nilai IC50 berturut-turut sebesar 60.18 ppm, 57.18 ppm, dan 54.82 ppm untuk tiga formula berbeda. Ekstrak murni memiliki IC50 45.11 ppm. Stabilitas sediaan masker gel terjaga meski terjadi perubahan pada pH dan viskositas, dengan formula 2 sebagai yang paling disukai menurut uji hedonik. Kesimpulannya, masker gel buah mahkota dewa memiliki aktivitas antioksidan yang efektif dan stabilitas yang baik.
Penelusuran in Silico Potensi Antimalaria dari Karang Lunak Lobophytum sp. sebagai Inhibitor Dihydroorotate Dehydrogenase dari Plasmodium falciparum
Authors: Arfan Arfan , Rayani Nur , Ode Aman La
Published: September 2024

ABSTRAK
Malaria merupakan salah satu penyakit infeksi yang disebabkan oleh parasit Plasmodium dan masih menjadi tantangan kesehatan dengan prevalensi yang persisten. Oleh karena itu, eksplorasi senyawa yang memiliki potensi sebagai antimalaria tetap menjadi aspek yang sangat penting. Studi ini bertujuan untuk mengevaluasi senyawa yang teridentifikasi dari karang lunak Lobophytum sp. sebagai kandidat antimalaria menggunakan teknik penambatan molekul, prediksi profil farmakokinetik dan drug likeness. Senyawa yang teridentifikasi dari karang lunak ini berhasil ditambatkan pada sisi aktif enzim dihydroorotate dehydrogenase (DHODH) dari Plasmodium falciparum menggunakan AutoDock Vina serta profil farmakokinetik dan drug likeness diprediksi menggunakan SwissADME. Senyawa Saurufuran B dan Oxyphyllacinol dari Lobophytum sp. menunjukkan energi afinitas pengikatan sebesar -9,4 kcal/mol dan -8,6 kcal/mol terhadap DHODH yang lebih negatif daripada senyawa lain tetapi lebih positif dari inhibitor F1T (-10,7 kcal/mol). Senyawa-senyawa ini memperlihatkan adanya ikatan hidrogen dengan asam amino His185, Lys429, Asn458, dan Ser505 dan interaksi hidrofobik dengan asam amino Cys175, Leu176, Phe188, Ile263, Arg265 dari enzim DHODH. Profil farmakokinetik dari senyawa tersebut mengungkapkan kelarutan yang baik dan penyerapan gastrointestinal yang tinggi, membuat mereka cocok untuk pengembangan obat. Senyawa tersebut diperkirakan dapat menghambat fungsi isoform dari CYP450 sebagai enzim pemetabolisme penting dalam tubuh. Selain itu, Saurufuran B dan Oxyphyllacinol juga memperlihatkan profil toksisitas yang aman dan memenuhi kriteria drug likeness berdasarkan aturan 5 Lipinski. Temuan ini menyarankan potensi dari Saurufuran B dan Oxyphyllacinol dari karang lunak Lobophytum sp. sebagai penghambat enzim DHODH dari P. falciparum dengan prediksi afinitas dan profil farmakokinetik yang menguntungkan untuk pengembangan obat antimalaria.
Pengembangan Gel Antiseptik Tangan Mengandung Minyak Atsiri Jeruk Lemon Menggunakan Metode Mikroemulsi Gel
Authors: Husni Patihul , Cahya Lestari Riska , Hartono Kusdi
Published: September 2024

Gel antiseptik tangan banyak digunakan untuk melindungi tubuh dari masuknya bakteri melalui tangan karena pemakaiannya praktis. Kulit buah jeruk lemon (Citrus limon (L) Burm. F) mengandung minyak atsiri yang mampu menghambat pertumbuhan bakteri sehingga dapat digunakan sebagai antiseptik alami. Penelitian ini bertujuan untuk mendapatkan formula terbaik gel antiseptik tangan mengandung minyak atsiri kulit jeruk lemon Citrus limon (L) Burm. F). Formula mikroemulsi minyak atsiri jeruk lemon dioptimasi dengan membuat variasi konsentrasi surfaktan (Tween 80) dan kosurfaktan (propilenglikol dan gliserin) yang selanjutnya dibuat sediaan gel menggunakan variasi konsentrasi gelling agent. Sediaan gel dilakukan uji stabilitas fisik yang meliputi pengujian organoleptis, homogenitas, pH, dan viskositas. Hasil optimasi formula mikroemulsi terbaik yaitu formula dengan surfaktan Tween 80 dan propilenglikol sebagai kosurfaktan. Sediaan gel antiseptik tangan minyak atsiri kulit jeruk lemon (Citrus limon (L) Burm. F) dengan formula F2 merupakan sediaan yang paling baik karena lebih stabil pada uji stabilitas fisik sediaan.
ANALISIS SISTEM PENDIDIKAN, MANAJEMEN DAN ADMINISTRASI ISTI’DADIYAH DALAM MENYIAPKAN SANTRI BARU MASUK LEMBAGA REGULER
Authors: Anwar Yusaul anwar , Miftahul Anam
Published: September 2024

Penelitian ini bertujuan mengetahui peran Isti’dadiyah yang menjadi wadah bagi santri baru, khususnya yang belum berpengalaman madrasah diniyah sebelum mondok, dan menyiapkan mereka agar bisa bersaing di lembaga Ula, Wustha dan Ulya. Penelitian ini menggunakan metode kualitatif fenomenologi dengan cara observasi sekaligus wawancara kepada beberapa narasumber bersangkutan, data yang diperoleh juga berasal dari data santri baru, gambar, kata berbentuk narasi dan hasil pengamatan. Sehingga dapat diketahui betapa pentingnya adanya Isti’dadiyah bagi santri baru, selain itu juga bisa membantu mereka para santri baru yang sudah memiliki usia di atas yang lain namun belum berpengalaman baca tulis arab. Adanya Isti’dadiyah juga mempersingkat pembelajaran baca kitab, yang seharusnya ditempuh dalam 3 tahun, dengan adanya isti’dadiyah cukup dengan 1 tahun. Karena masalah pesantren yang dialami sekarang banyaknya santri baru yang sudah memiliki usia setara kelas Ulya belum bisa apa-apa hingga harus dimasukkan ke Ula, hal ini menyebabkan santri yang bersangkutan tidak kerasan karena merasa malu, teman-temannya kecil semua, sedangkan dirinya sendiri sudah berusia lebih tua belum bisa baca arab. Isti’dadiyah bisa menjadi jembatan bagi mereka untuk mengejar ketertinggalan pelajaran dalam waktu singkat.
 
Abstract:
This study aims to determine the role of Isti'dadiyah which is a forum for new students, especially those who have not experienced Madrasah diniyah before boarding, and prepare them to be able to compete in Ula, Wustha and Ulya institutions. This study uses a qualitative phenomenological method by observing as well as interviewing several relevant sources, the data obtained also comes from new student data, pictures, words in the form of narratives and observations. So that it can be seen how important the existence of Isti'dadiyah is for new students, besides that it can also help them new students who already have an age above the others but have no experience in reading and writing Arabic. The existence of Isti'dadiyah also shortens learning to read books, which should be taken in 3 years, with the existence of Isti'dadiyah it is enough for 1 year. Because of the problems in the pesantren that are currently experienced, many new students who are of the same age as Ulya's class can't do anything about it until they have to be admitted to the Ula, this causes the students concerned to not feel at home because they feel ashamed, all of their friends are small, while he himself is already old. Older can't read Arabic. Isti'dadiyah can be a bridge for them to catch up on lessons in a short time.
MANAJEMEN SUPERVISI AKADEMIK KEPALA MADRASAH DALAM MENINGKATKAN KINERJA GURU DI MI MABDAUL ULUM
Authors: Sholihah Imro'atus
Published: September 2024

Article this aims to knowing the academic supervision management of madrasah principals in improving teacher performance at Madrasah Ibtidaiyah Mabdaul Ulum. So the research wants to know the efforts and problems of the academic section in improving teacher performance, especially in planning, organizing, implementing and evaluating. The method used by the researcher is a qualitative method, while the which used is Approach Qualitative Descriptive . Technique data collection is observation, interviews, and documentation. Whereas technical analysis data use Triangulation Source and Technique. So that h results research is to breastfeed in the new school year and include teachers. This academic supervision program is structured based on the problems faced by teachers regarding learning problems and adjusts the needs of teachers. The implementation of academic supervision has been planned in accordance with supervision techniques including group supervision and individual supervision. Evaluation is seen from the planning and implementation of academic supervision programs that are implemented and follow-up actions follow up on what the madrasa principal does by providing coaching or training to teacher which not yet Fulfill standard as well as appreciation on teacher which meet the standards and factors supporting and inhibiting academic supervision head master. Based on the results of these studies, the implementation of academic supervision management of madrasah principals in improving teacher performance in Madrasah Ibtidaiyah Mabdaul Ulum not yet done with good in enhancement teacher performance.
PENANAMAN KARAKTER ISLAMI MELALUI TAHFIDZ AL- QUR’AN DI YAYASAN SABILUL MUTTAQIN BONDOWOSO
Authors: Zamilul Mas'ad  , Erfendi
Published: September 2024

Penelitian ini bertujuan untuk mengetahui langkah-langkah penanaman karakter Islami melalui Tahfidz Al Qur’an di lembaga pendidikan Yayasan Sabilul Muttaqin. untuk mengidentifikasi karakter Islami siswa di lembaga pendidikan Yayasan Sabilul Muttaqin melalui program Tahfidz Al Qur’an. Penelitian ini menggunakan jenis penelitian deskriftif kualitatif dengan teknik analisis triagulasi data. Untuk mendapatkan informasi peneliti menggunakan teknik wawancara, observasi dan dokumentasi dengan subjek ketua Yayasan ,kepala sekolah dan guru. Berdasarkan hasil didapatkan: Langkah-langkah penanaman karakter Islami melalui Tahfidz Al Qur’an di lembaga pendidikan Yayasan Sabilul Muttaqin telah memberikan salah satu bentuk dan pola penanaman karakter Islami melaluiTahfidz Al Qur’an yaitu bersih, istiqomah, bersabar dan disiplin.Tujuan penelitian ini adalah 1.Untuk mengetahui langkah-langkah penanaman karakter Islami melalui Tahfidz Al Qur’an. 2. Untuk mengetahui implementasi penanaman karakter Islami melalui Tahfidz Al Qur’an
ANALISIS SOSIAL HASSAN HANAFI DAN IMPLIKASINYA TERHADAP PENDIDIKAN ISLAM
Authors: Muhammad Lutfi
Published: September 2024

Abstrac
This paper illustrates Hassan Hanafi's thoughts about his rejection of westernization. Western superior justification is just a Western guise in smoothing the occupation of the East. Hassan Hanafi tried to counter with his idea of ​​Occidentalism. An idea that was born from the project of Islamic Left thinking and al-Turats wa al-Tajdid. This paper is a literature review that was extracted from several primary and secondary sources. The purpose of this paper is to examine the thoughts of Hassan Hanafi, who then draws on implication for current thinking.
 
Abstrak
Tulisan ini menggambarkan pemikiran Hassan Hanafi tentang penolakannya terhadap westernisasi. Justifikasi superior Barat hanyalah sebuah kedok Barat dalam memuluskan penjajahan terhadap Dunia Timur. Hassan Hanafi mencoba mengkunter dengan gagasannya berupa Oksidentalisme. Sebuah gagasan yang lahir dari proyek pemikiran Kiri Islam dan al-Turats wa al-Tajdid. Tulisan ini merupakan kajian pustaka yang digali dari beberapa sumber primer dan sekunder. Tujuan tulisan ini ialah untuk mengkaji pemikiran Hassan Hanafi yang kemudian ditarik pada sebuah implikasi terhadap pemikiran di masa sekarang.
Konseling Pastoral Pada Orang Dengan HIV/AIDS Yang Mengalami Diskriminasi Dari Masyarakat
Authors: Oley Deby Meilina
Published: September 2024

The aim of this study is to analyze people with HIV/AIDS who have experienced discrimination in the Batamang Plus Foundation and describe a model of supporting pastoral counseling to people with AIDS who have been discriminated against. This research is qualitative research with case study methods implemented in the Batamang Plus Manado Foundation 2023. Data collected through observations, interviews, documentation, pastoral counseling, from the results of analysis and interpretation of data obtained indications that (1) People with HIV/AIDS are being discriminated against by their family and environment (2) Discrimination affects the irregular and mental emotions of people with HIV / AIDS. Based on the findings, in order to address the situation experienced by people with HIV/AIDS, the researchers performed a pastoral accompaniment of six meetings and as a result, subjects who were initially injured due to discrimination from family and environment can accept the reality and forgive the family and are more willing to accept themselves and not blame themselves and approach God. Thus it should be understood that the words and behavior to others must be consistent with knowledge and what is said must be compatible with the facts that do not judge or discriminate against others.
MME and PTPRC: key renal biomarkers in lupus nephritis
Authors: Wen Min , Hun Marady , Zhao Mingyi , He Qingnan
Published: September 2024

Background

Lupus nephritis (LN) is an autoimmune-related kidney disease with a poor prognosis, however the potential pathogenic mechanism remains unclear and there is a lack of precise biomarkers. Therefore, a thorough screening and identification of renal markers in LN are immensely beneficial to the research on its pathogenic mechanisms and treatment strategies.

Methods

We utilized bioinformatics to analyze the differentially expressed genes (DEGs) at the transcriptome level of three clusters: total renal, glomeruli, and renal tubulointerstitium in the GEO database to discover potential renal biomarkers of LN. We utilized NephroSeq datasets and measured mRNA and protein levels in the kidneys of MRL/lpr mice to confirm the expression of key DEGs.

Results

Seven significantly differential genes (EGR1, MME, PTPRC, RORC, MX1, ZBTB16, FKBP5) were revealed from the transcriptome database of GSE200306, which were mostly enriched in the pathway of the hematopoietic cell lineage and T cell differentiation respectively by KEGG and GO analysis. The seven hot differential genes were verified to have consistent change trends using three datasets from NephroSeq database. The receiver operating characteristic (ROC) curve indicated that five DEGs (PTPRC, MX1, EGR1, MME and RORC) exhibited a higher diagnostic ROC value in both the glomerulus and tubulointerstitium group. Validation of core genes using MRL/lpr mice showed that MME and PTPRC exhibit significantly differential mRNA and protein expression patterns in mouse kidneys like the datasets.

Conclusions

This study identified seven key renal biomarkers through bioinformatics analysis using the GEO and NephroSeq databases. It was identified that MME and PTPRC may have a high predictive value as renal biomarkers in the pathogenesis of LN, as confirmed by animal validation.
Unravelling the Psychological Impact of Trimethylaminuria: Insights into the Management Strategies
Authors: Ganjewar Shravani , Sapkale Bhagyesh , Raj Priyanshu , Totade Sangeeta , Lade Nitin
Published: September 2024

Trimethylaminuria (TMAU), colloquially known as fish odour syndrome, is a rare metabolic disorder characterised by the body’s inability to properly metabolise Trimethylamine (TMA), resulting in a distinctive and unpleasant fishy odour in bodily secretions. This comprehensive review explores the pathophysiology, clinical manifestations, genetic basis, diagnostic challenges, and psychological impact of TMAU, along with management strategies. Genetic mutations affecting the flavin-containing monooxygenase 3 (FMO3) enzyme, which is responsible for TMA metabolism, contribute to the condition’s hereditary nature. Diagnosis can be challenging due to intermittent symptoms and overlaps with other conditions, such as Olfactory Reference Syndrome (ORS). The psychosocial impact of TMAU can be profound, leading to embarrassment, social isolation, and mental health issues. Management strategies include dietary modifications, supplements, antibiotics, and hygiene measures to alleviate symptoms. Despite advances in understanding TMAU, further research is needed to enhance diagnostic accuracy and therapeutic approaches, ultimately improving the quality of life for affected individuals.
Comparison of Analgesic Efficacy of Levobupivacaine with or without Dexamethasone in Lower Abdominal Surgeries under Subarachnoid Block: A Pilot Randomised Controlled Trial
Authors: Rautela Rajesh Singh , Gupta Vibhor , Singhal Rachit , Salhotra Rashmi , Tyagi Asha , Mathew Naveen A
Published: September 2024

Introduction: Subarachnoid Block (SAB) is a commonly used technique for lower abdominal surgery. Dexamethasone has been proven effective as an additive when used with bupivacaine. However, there has been no study comparing the analgesic efficacy of dexamethasone with levobupivacaine under SAB. Aim: To compare the analgesic efficacy of levobupivacaine with or without dexamethasone in patients scheduled for lower abdominal surgeries. Materials and Methods: A pilot randomised doubleblind controlled trial was undertaken in the Department of Anaesthesiology, University College of Medical Sciences Guru Tagh Bahudur (UCMS-GTB) Hospital, New Delhi, India on 60 patients with Americian Soceity of Anaesthesiolgy (ASA) grade I or II, aged 18-65 years, undergoing lower abdominal surgeries under SAB from January 2021 to August 2022. In Group LS, 12.5 mg of 0.5% isobaric levobupivacaine (2.5 mL) with normal saline (1 mL) was administered, and in Group LD, 12.5 mg of 0.5% isobaric levobupivacaine (2.5 mL) with 4 mg dexamethasone (1 mL) was given. Patients were assessed for sensory and motor block, haemodynamic parameters, pain score, and side-effects. Unpaired t-tests/Mann-Whitney U tests were used to determine significance. A p-value of less than 0.05 was considered significant. Results: The two groups were comparable in terms of demographic profile. The age in the LS group was 37.80±9.98 years, and in the LD group, it was 38.63±12.37 years. The maleto-female ratio in the LS and LD groups was 17:13 and 21:9, respectively. The weight range in both groups was between 50 to 67 kg. The Basal Metabolic Index (BMI) was 22.40±2.43 kg/ m2 and 21.70±2.21 kg/m2 in the LD and LS groups, respectively. All these parameters, including height, had a p-value of more than 0.005, except for the duration of analgesia. The duration of effective analgesia was also longer in the LD group (247.00±36.69 min) than in the LS group (138.50±22.52 min) with a p-value of <0.001. The time of onset of sensory block was 9.13±2.98 minutes in the LD group and 10.30±3.06 minutes in the LS group, which was statistically insignificant. Conclusion: Authors concluded addition of 4 mg (1 mL) of dexamethasone to 2.5 mL of 0.5% isobaric levobupivacaine provides a clinically longer duration of effective analgesia with early onset and better quality of sensory and motor block than 2.5 mL of 0.5% isobaric levobupivacaine alone. Therefore, 4 mg of dexamethasone with 2.5 mL of 0.5% isobaric levobupivacaine is recommended for lower abdominal surgeries under SAB.
Analysing Public-private Partnership Practices for Haemodialysis Services using Collaborative Governance Framework: A Qualitative Study
Authors: Basabih Masyitoh , Prasojo Eko , Rahayu Amy Yayuk Sri
Published: September 2024

Introduction: Public-Private Partnerships (PPPs) are viewed as a solution for gaps in healthcare access, quality and affordability. Operational Cooperation (OC) is a common practice in haemodialysis services at regional hospitals in Indonesia. Aim: To analyse the implementation of OC for haemodialysis services at Regional Public Service Agency (RPSA) hospitals from the perspective of collaborative governance. Materials and Methods: This qualitative research utilised interviews, focus groups, and document analysis to explore the implementation of OC from a collaborative governance perspective. The study was conducted at Regional Hospitals, Regional Government Offices, the Ministry of Health, the Ministry of Home Affairs, Medical Device Companies, and the Association of Regional Hospitals of Indonesia from December 2021 to March 2022. Data were collected from indepth interviews and Focus Group Discussions (FGDs) with 15 informants, including policymakers, hospital managers, and partner companies. Other data included nine national-level and 29 regional-level policy documents. NVivo software was used for coding and to ensure data validity through triangulation. The parameters evaluated included system context, drivers, collaborative processes, and collaboration outcomes according to Emerson’s collaborative governance framework. Results: The implementation of PPP for haemodialysis services at regional hospitals is driven by the need for these services and limited resources. Despite the incomplete policy framework, regional hospitals are taking steps to establish collaboration. Hospitals are streamlining operational process flows, creating a domino effect for other services. Even without a feasibility study, the implementation of PPP in regional hospitals in Indonesia has successfully addressed the community’s need for access to haemodialysis services. Conclusion: The implementation of PPPs in the form of OC has successfully expanded access to haemodialysis services. However, challenges related to policy, human resources, and corruption pose significant obstacles to the implementation of OC.
ÇOK DİLLİLİK VE DÎVÂNU LÛGATİ’T-TÜRK
Authors: Ulusoy Yusuf
Published: September 2024

Çok dillilik, toplum dilbilimin alt alanıdır. İki veya daha fazla dili kullanan bireyler çok dilli bireylerdir. Günümüzde, her ülkede çok dilli bireylerle karşılaşmak mümkündür. Çok dillilik, günümüzde toplum dilbilim araştırmacıları tarafından araştırılan bir konudur. 11. yüzyılda da çok dilli bireyler yaşamıştır. Dîvânu Lûgati’t-Türk, çok dilli bireyleri ve toplumları günümüze taşıyan önemli bir sözlüktür. Kâşgarlı Mahmud, Türk boylarından derlediği bilgiler ışığında çok dilli bireylerin yaşadığını eserinde işler. 11. yüzyılda, birden çok dili bilen ve kullanan Türk boyları çalışmamızın konusudur. Çalışmamızda, Ahmet B. Ercilasun ve Ziyat Akkoyunlu tarafından hazırlanan Dîvânu Lûgati’t-Türk incelenerek çok dilli boy ve uruklar araştırılmıştır. Boy ve uruklar, yaşadıkları coğrafya, ekonomik faaliyetleri, dinleri ve etkilenebilecekleri komşuları da göz önünde bulundurularak incelenmiştir. Araştırmamız, nitel araştırma yöntemlerinden doküman incelemesi tekniğiyle yapılmıştır.
LEYLA FONTEN’İN KİTAPLARININ İÇERDİĞİ EVRENSEL DEĞERLERE GÖRE İNCELENMESİ
Authors: Oguz Namdar Ayşegül , Günaydın Yusuf , Özdemir Caner
Published: September 2024

Bu araştırmanın amacı Tülin Kozikoğlu’nun Leyla Fonten serisindeki kitaplarda yer alan evrensel değerlerin incelenmesi ve konu ile ilgili sınıf öğretmenlerinin görüşlerinin alınmasıdır. Tülin Kozikoğlu’nun Leyla Fonten serisindeki kitaplarında yer alan evrensel değerlere ilişkin sınıf öğretmenlerinin görüşlerinin alınması aşamasında nitel araştırma yaklaşımlarından durum çalışması deseninden yararlanılmıştır. Tülin Kozikoğlu’nun Leyla Fonten kitaplarındaki evrensel değerlerin incelenmesi aşamasında doküman inceleme yönteminden yararlanılmıştır. Bu bağlamda dokuz kitaptan oluşan seri iki bağımsız kodlayıcı tarafından okunmuş, analiz edilmiştir. Kitaplardan elde edilen verilerin analizinde, içerik analizi ile kod ve frekans tabloları hazırlanmış, doğrudan alıntılar yoluyla kitaptan alıntılara yer verilmiştir. Sınıf öğretmenlerinin görüşlerinin içerik analizinden yararlanılmış, kod ve frekans tabloları hazırlanıp doğrudan alıntılarla öğretmen görüşlerine yer verilmiştir. Leyla Fonten serisi içerdiği evrensel değerler bakımından incelenmiş; en çok tekrar edilen evrensel değerlerin saygı, sorumluluk, hoşgörü, birlik olduğu görülmüştür. Sonuçlardan yola çıkarak önerilere yer verilmiştir.
İLKOKULLARDA ÜCRETSİZ OLARAK DAĞITILAN YARDIMCI KAYNAK KİTAPLAR İLE İLGİLİ ÖĞRETMEN GÖRÜŞLERİ
Authors: Karaman Hamdi , Yılar Ömer
Published: September 2024

Bu araştırmada ilkokullarda 2022-2023 eğitim öğretim yılında MEB tarafından ücretsiz bir şekilde dağıtılan yardımcı kaynak kitaplar ile ilgili sınıf öğretmenlerinin görüşlerinin incelenmesi amaçlanmıştır. Araştırmada nitel araştırma yöntemlerinden olgu bilim kullanılmıştır. Araştırma kapsamında ilkokullarda çalışan 20 sınıf öğretmeni ile görüşmeler yapılmıştır. Araştırma sonuçlarına bakıldığında öğretmen görüşlerine göre; yardımcı kaynak kitapların konu anlatımı yetersiz, örnek sayısı az ve kitaplar öğrenci düzeyinin üzerindedir. Bunlarla beraber yardımcı kaynaklar içindeki metinler ve sorular, uzun ve sıkıcı tasarlanmıştır. MEB tarafından dağıtılan yardımcı kaynaklar ile özel yayınevleri tarafından basılan yardımcı kaynakları karşılaştıran öğretmenlere göre özel kaynakların soru kalıbı, etkinlik örnekleri, ilgi çekiciliği, ölçme ve değerlendirme kapsayıcılığı daha fazladır.
DUMÉZİL VE TRİNİTE TEORİSİ
Authors: Saluk Reyhan Gökben
Published: September 2024

Dumézil (1898-1986) antik kültürleri açıklamak için mitleri üç ilkeye dayalı olarak sınıflandırmış ve Hint-Avrupa toplumlarının inanç sistemleri ve sosyal yapıları hakkında analojiler kurmuştur. Ayrıca toplumların iktidar sınıfı (soy tabakası), üretici sınıf (çiftçiler ve zanaatkârlar) ve savunucu sınıf (savaşçılar) olmak üzere üç ana işlevsel ilkeyle organize olduğunu iddia etmiştir. Dumézil’e göre, bu üç sınıf arasındaki ilişki; mitolojik rivâyetlerde ve ritüellerde görülebilmektedir. Dumézil'in Trinite teorisi, Hint-Avrupa kültür geleneğini sosyo-politik kategorilere dayanarak tanımlamaya çalışmaktadır. Uzmanlar buna paralel olarak teorinin genelleme eğiliminde olduğunu, tüm toplumların bu üç sınıf yapısına uymadığını savunmuşlardır. Teorinin öne sürdüğü evrensel örüntülerin Hint-Avrupa sahası içindeki her kültür alanı için uygulanabilir olup olmadığı da tartışılmalıdır. Bu makalede; mitlerin toplumsal yapı çözümlemesindeki fonksiyonu teorinin bazı takipçileri üzerinden değerlendirilmiştir.
HÜSEYİN HÜSNÜ CIRITLI’NIN TÜRKİYE’DE ÖĞRETMEN YETİŞTİRME SÜRECİ VE ÖĞRETMENLİK MESLEĞİ İLE İLGİLİ GÖRÜŞLERİ
Authors: Korkmaz Önder , Güçlü Mustafa
Published: September 2024

Türkiye’de eğitim politikalarının şekillenmesinde dönemin düşünürlerinin ve eğitimcilerinin önemli etkileri olmuştur. Bu düşünür ve eğitimcilerden birisi de uzun yıllar Gazi Eğitim Enstitüsünde ve Millî Eğitim Bakanlığında görev yapmış olan Hüseyin Hüsnü Cırıtlı’dır. Bu araştırmanın amacı Cırıtlı’nın Türkiye’de öğretmen yetiştirme süreci ve öğretmenlik mesleği ile ilgili görüşlerini ortaya koymaktır. Araştırma belge inceleme yöntemiyle yürütülmüş ve verilerin çözümlenmesi için içerik analizi tekniği kullanılmıştır. Araştırma sonucunda, eğitimin millî olması, öğretmen yetiştirme sürecinde Millî Eğitim Bakanlığının söz hakkının olması, ülke genelinde öğretmen yetiştirme konusunda iş birliği yapılması ve standartlar belirlenmesi, öğretmenlerin özel nitelikler taşıması, hizmet içinde eğitimin önemli hâle gelmesi ve öğrencilerin öğrenmelerinde öğretmen etkeninin önemi gibi sonuçlara ulaşılmıştır.
TÜRKÇEDE BAZI BULAŞMA (CONTAMINATION) ÖRNEKLERİNDE ANLAMIN BULAŞMA ÜZERİNDEKİ ETKİLERİ
Authors: Çebi İhsan Sabri
Published: September 2024

Bulaşma, bir dilde iki kelimenin birbiriyle etkileşmesinden kaynaklanan üçüncü bir şeklin ortaya çıkması durumudur. Bulaşma sonucunda yeni ortaya çıkan kelimede daha çok şekil benzerliği ön plandadır. Ancak anlam ilişkisi, bulaşan şekiller arasında önemli rol oynar. Türkçe kelimelerde rastladığımız bulaşma örneklerinde bazı ses olayları yaşanmıştır. Fakat bulaşma ile ortaya çıkan ses olayı, diğer ses olayları gibi değildir. Bulaşma, örnekseme adı verilen, dildeki bir kelimeye benzetilerek yeni bir kelime türetilmesi hadisesi
de değildir. Bulaşmada ölçüt, etkilenen iki kelimeden üçüncü bir kelimenin ortaya çıkmış olmasıdır. Türkçede bir kısmı edebî dile girmiş bir kısmı konuşma dilinde kalmış olmak üzere bulaşma örnekleri mevcuttur. Bu yazıda bulaşma örneklerinde “anlam”ın tesiri üzerinde durulmuştur.
Influence of Insecticide Application on Pollinators and Predatory Arthropods in Watermelon Agroecosystem
Authors: B. R. Archana, , Pujar Kishor , T. Chethan, , Hiremath Kavya, M. , Godavari  , K.C. Arpitha , Manjula  , M. Harish Varma,
Published: September 2024

This study, conducted from January to April 2021 in Kandavara village, Karnataka, examined the effects of various insecticides on honeybees, spiders, and coccinellids in watermelon crops. Using a randomized complete block design, watermelon plants were treated with insecticides when pest populations reached economic thresholds. Honeybee foraging activity and populations of spiders and coccinellids were monitored before treatment and at 3,7 and 10 days post-application. Results showed that untreated control plots consistently had the highest activity of all beneficial insects. Among the insecticides tested, Spinosad 45 SC was the least harmful, with relatively higher levels of honeybee and natural enemy activity. In contrast, Imidacloprid 17.8 SL and Acephate 75 SP were the most detrimental, resulting in significantly lower activity levels for honeybees, spiders, and coccinellids. These findings highlight the importance of selecting insecticides that minimize harm to beneficial insects, emphasizing the need for integrated pest management practices that balance effective pest control with the preservation of essential ecosystem services.
Seasonality Effects, Stock Exchange and Foreign Exchange Markets: Comparative Analysis of Volatility Behavior During Covid-19
Authors: Umoru David , Aliu Timothy Igbafe , Igbinovia Beauty
Published: September 2024

This study investigated the effects of seasonality on stock exchange and foreign exchange markets of two WAMZ and two BRICS countries which include Nigeria, Ghana, and Brazil and China. The Auto Regressive Integrated Moving Average (ARIMA) regression approach and the Markov-regime switching methodologies were executed. The parsimonious ARIMA estimates reported Nigeria’s stock returns demonstrated lower volatility (SIGMASQ = 0.000141) than Ghana’s stock returns (SIGMASQ = 0.004003). Similarly, Nigeria had a lower returns volatility than Ghana (SIGMASQ = 0.001829 < 0.07727) in the foreign exchange market of their respective local currencies in relation to the US dollar during the covid-19 era. Comparatively, Nigeria’s stock and foreign exchange market performance showed lower returns volatility behaviour than Ghana’s markets during the covid-19 period. Brazil’s stock returns and the foreign exchange market return on the Brazilian Real had higher volatility compared to the Chinese stock market returns and the return on the Chinese Yuan exchange rate vis-à-vis the US dollar during the covid-19 era. Comparatively, Brazil’s stock and foreign exchange performance showed higher returns volatility behaviour than China during the covid-19 period. The ARIMA estimates were upheld by the Markov-switching regression results which reveal highest volatility effect of the foreign exchange market in Ghana and Brazil. Ghana's stock market volatility reverted more quickly than that of Nigeria, while in the second and third regimes, volatility of the Nigeria's stock exchange reverted more speedily than that of Ghana. The Markov estimates also reveals that China had more time than Brazil for stock market volatility to be repaired in the first regime, 40.43 months as against 36.77 months but a much lower time for China’s stock volatility to be restored in the second and third regimes, during and after the covid-19 pandemic. The expected durations in the regimes for the Brazilian forex market are 40.96, 47.98, and 33.99 months compared to 29.78, 27.55, and 21.65 months in the first, second, and third regimes. The study thus established that volatility on the returns of the Brazilian foreign exchange market before, during, and after the covid-19 pandemic takes longer time to die off unlike in the case of China’s forex market. The empirical findings validate the significance of the business cycle theory in these markets. Accordingly, our findings explicate the presence of sizable effects of cyclical swings on the stock and foreign exchange markets of Ghana, and Brazil compared to that of Nigeria and China respectively.
Study on the Effect of Foliar Fertilizers on the Growth and Yield of V108 Heat-Tolerant Cucumber Variety
Authors: Khoi Nguyen Tuan , Thom Pham Thi
Published: September 2024

This study evaluates the efficacy of various foliar fertilizers on the growth and yield of the heat-tolerant cucumber variety TV108. The experimental design included six different foliar fertilizers and a control, with applications made weekly at a concentration of 1 mL per liter of water. Results showed that all foliar treatments significantly enhanced plant height compared to the control. Among these, Treatment T4 (ATONIK foliar fertilizer) demonstrated the most pronounced effect, achieving a main stem height of 216.57 cm by the 70th day, which was significantly higher than other treatments and the control. Treatment T4 also excelled in increasing stem diameter, with a final measurement of 1.48 cm, and in promoting both male and female flower formation. The fruit set rate was highest in Treatment T4, reaching 28.67% on day 56 and maintaining at 8.67% by day 70. This treatment also proved most effective in reducing the incidence of key diseases and pests, including powdery mildew, white mold, green worms, and yellow beetles. Regarding yield, Treatment T4 produced the highest individual fruit yield (2.32 kg/plant), actual yield (33.8 tons/ha), and theoretical yield (84.91 tons/ha). Additionally, it enhanced fruit quality, as indicated by the largest fruit length (15.22 cm), diameter (4.13 cm), and the highest Brix value (3.50%). These results substantiate that Treatment T4 is the most effective foliar fertilizer for enhancing both growth and quality of heat-tolerant cucumbers under experimental conditions.
Analysing the Growth and Instability of Cereal Crop Production Across Kharif and Rabi Seasons in Western Odisha, India
Authors: Kumar Ravi Ranjan , Baishya Moumita , Panigrahi Anupam , Das Kakali
Published: September 2024

Over the past decade, agricultural development in India has evolved significantly due to a range of influencing factors. In Odisha, the agricultural sector is particularly susceptible to risks and uncertainties, making it crucial to assess growth and instability. This study provides an in-depth analysis of the compound growth rate and Coppock’s Instability Index for four major cereal crops-rice and maize for both Kharif and Rabi seasons, as well as ragi and wheat, each in their respective seasons. Utilizing secondary data spanning from 1993-94 to 2022-23, the research evaluates and compares the growth and instability of production of these crops across districts in Western Odisha. The study also ranks districts based on these metrics, offering a detailed comparison between Kharif and Rabi seasons. The results highlight differences in growth trends and instability levels among the crops, providing valuable insights into the agricultural patterns and challenges faced by the region. The final findings reveal that rice tends to have lower growth rates but greater stability in the kharif season compared to the rabi season, while maize shows overall positive growth. Ragi struggles with negative growth during the kharif season, and wheat experiences declining growth in the rabi season.