bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance of SMEs: Literature synthesis of contingency models
Authors: Ramirez Humberto , Sang Lim Thien
Published: September 2021

The fundamental issue of performance of SMEs has been intensively analyzed by academia mainly through performance models. Performance models are largely focused on predicting failure and have intrinsic limitations. The present literature synthesis proposes an alternative perspective from seemingly unconnected empirical studies, which share the performance of SMEs as a common criterion: contingency models. Such perspective emphasizes the positive facet of SMEs results and complements the current academic standard of prediction models. This study performed integration and conceptual classification of 99 articles cataloged as contingency models and published by reputed journals from 1999 to 2019. The evidence from the integrated empirical literature revealed an ample and diverse set of supported variables that explain a positive economic outcome in small ventures. The analysis and classification of the articles derived 7 sections, 24 categories and 131 supported variables, which are intended to help improve the scholarly and professional analysis of SME performance due to the inherent viability of the integrated articles, proving a benign economic output. This view contradicts the current paradigm of performance models, which is insufficient to predict or explain how to improve SMEs results. The integrated elements developed by this study can work as a framework for the academic research of SMEs performance, and practical guidance for SMEs’ managers. This synthesis sets an agenda for further academic research in the field of SME performance, specifically in the areas of methodology, operationalization of performance, and empirical research.
Geometrically non-linear free and forced vibration of a shallow arch
Authors: Outassafte Omar , Adri Ahmed , El Khouddar Yassine , Rifai Said , Benamar Rhali
Published: September 2021

The purpose of this present work is to investigate the geometrical non-linearity in free and forced vibration of a shallow arch elastically restrained at the ends. The non-linear governing equilibrium equation of the shallow arch is obtained after the Euler Bernoulli theory and the Von Karman geometrical non-linearity assumptions. After applying the ends conditions, the eigenvalues problem of the generalized trancendant equation have been determined iteratively using the Newton-Raphson algorithm. The kinetic and total strain energy have been discretized into a series of a finite spatial functions which are a combination of linear modes and basic function contribution coefficients. Using Hamilton’s principle energy and spectral analysis, the problem is reduced into a set of non-linear algebraic equations that solved numerically using an approximate explicit method developed previously the so-called second formulation. Considering a multimode approach, the effect of initial rise and concentrated force on non-linear behaviour of system has been illustrated in the backbone curves giving the non-linear amplitude-frequency dependence. The corresponding non-linear deflections and curvatures have been plotted for various vibration amplitudes.
Perioperative SARS-CoV-2 Infection in Patients Undergoing Elective Surgery in Gynecology Clinic: Tertiary Center Experience
Authors: Reyhan Toptas Gulnihal , Unlubilgin Eylem , Kinay Tugba , Dogan Ali Riza , Akgul Mehmet Akif , Aslanova Sitare , Ercan Emel Ebru , Korkmaz Vakkas , Erturk Aksakal Sezin , Ustun Yaprak
Published: September 2021

OBJECTIVE: The objective of this study was to determine the incidence of perioperative “severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)” infection among women, operated during Coronavirus disease-2019 (COVID-19) era.
STUDY DESIGN: All patients who were operated on between March 11, 2020, and December 31, 2020, in our gynecology clinic were included in this cross-sectional study. The clinical and demographic characteristics of the patients, preoperative and postoperative SARS-CoV-2 positivity, the progress of the infection, and the survival rates in positive cases were analyzed. COVID-19 cases were diagnosed by reverse transcription-polymerase chain reaction testing for SARS-CoV-2.
RESULTS: Operations of 133 (33%) of 406 patients were canceled for various reasons. 275 patients were operated on. Preoperatively three patients were diagnosed with COVID-19. One of these patients died and two were operated on after treatment and self-isolation. Only one (0.4%) patient was diagnosed with COVID-19 30 days postoperatively and completely recovered. We calculated the perioperative SARS-CoV-2 positivity rate as 1.4% (276 surgeries were planned and 4 patients were diagnosed with COVID-19). During the study, 107 physicians worked in our clinic alternately. Two (1.8%) of these physicians were diagnosed with COVID-19 and completely recovered without the need for intensive care. In addition, nine patients who were previously diagnosed with COVID-19 were operated on. Postoperative respiratory and other system complications did not occur in nine patients, previously diagnosed with COVID-19.
CONCLUSION: The results of our study show that gynecological surgical procedures do not increase the transmission and mortality rates of SARS-CoV-2 among patients and healthcare professionals as long as infection control measures are followed.
Assessment of climate change impact on water availability in the upper Dong Nai River Basin, Vietnam
Authors: Khoi D. N. , Nguyen V. T. , Sam T. T. , Mai N. T. H. , Vuong N. D. , Cuong H. V.
Published: September 2021

On a global scale, climate change is projected to have detrimental impacts on water availability. This situation will become more severe owing to accumulated impacts of climate change and anthropogenic activities. This study aims to investigate climate change impact on water availability in the upper Dong Nai River Basin using the Soil and Water Assessment Tool (SWAT) and Water Evaluation and Planning (WEAP) models. Future rainfall scenarios were downscaled from five different general circulation models under RCP4.5 and RCP8.5 using the Long Ashton Research Station Weather Generator (LARS-WG) tool. Under the climate change impact, annual river discharge in the study region is generally projected to have upward trends in the future, except for the near-future period of the 2030s under RCP4.5. In addition, dry-seasonal river discharge is expected to be increased in the future. Considering the baseline condition of water use, there was an annual water shortage of approximately 32.9 × 103 m3, which mostly occurred in the dry season from January to March. Climate change may reduce the water shortage in the study region ranging from 7.0 to 30.1% in the future. Under the combined impacts of climate change and increasing water demand, the water shortage will vary from −18.6 to 6.0% in the future. The results can provide valuable insights to implement appropriate future water resources planning and management in the study region.
Integration of advanced optimization algorithms into least-square support vector machine (LSSVM) for water quality index prediction
Authors: Chia See Leng , Chia Min Yan , Koo Chai Hoon , Huang Yuk Feng
Published: September 2021

Machine learning models hybridized with optimization algorithms have been applied to many real-life applications, including the prediction of water quality. However, the emergence of newly developed advanced algorithms can provide new scopes and possibilities for further enhancements. In this study, the least-square support vector machine (LSSVM) integrated with advanced optimization algorithms is presented, for the first time, in the prediction of the water quality index (WQI) at the Klang River of Malaysia. Thereafter, the LSSVM model using RBF kernel was optimized using the hybrid particle swarm optimization and genetic algorithm (HPSOGA), whale optimization based on self-adapting parameter adjustment and mix mutation strategy (SMWOA) as well as ameliorative moth-flame optimization (AMFO) separately. It was found that the SMWOA-LSSVM model had the better performance for WQI prediction by having the best achievement root mean square error (RMSE), mean absolute error (MAE), coefficient of determination (R2) and mean absolute percentage error (MAPE). Comprehensive comparison was done using the global performance indicator (GPI), whereby the SMWOA-LSSVM had the highest average score of 0.31. This could be attributed to the internal architecture of the SMWOA, which was catered to avoid local optima within short optimization period.
Porous carbon aerogel derived from bacterial cellulose with prominent potential for efficient removal of antibiotics from the aquatic matrix
Authors: Wei Mengdan , Zheng Huabao , Zeng Tainan , Yang Jian , Fang Xiaobo , Zhang Cheng
Published: September 2021

The development of adsorption methods for the remediation of antibiotics pollution in water is hindered by the lack of high-performance sorbents. In this study, a nanofiber carbon aerogel was prepared using bacterial cellulose and its adsorption performances for three common antibiotics (norfloxacin, sulfamethoxazole, and chloramphenicol) in water were evaluated. The as-prepared nanofiber carbon aerogel showed a higher adsorption capacity toward target antibiotics compared to other adsorbents reported in the literature. The maximum adsorption capacities for norfloxacin, sulfamethoxazole, and chloramphenicol were 1,926, 1,264, and 525 mg/g, respectively at 298 K. Notably, the nanofiber carbon aerogel was able to adsorb 80% of the equilibrium adsorption capacity within 1 min and reach equilibrium within 15 min. After five regeneration cycles, the adsorption capacity still reached 1,166, 847, and 428 mg/g for norfloxacin, sulfamethoxazole, and chloramphenicol, respectively. The characterization results showed that the carbon aerogel exhibited a high specific surface area (1,505 m2/g) and a layered porous network structure. Furthermore, the mechanistic study reveals that the enhanced antibiotic adsorption by the as-prepared nanofiber carbon aerogel was attributed to the pore filling effect, hydrogen bonding, hydrophobic effect, electrostatic interaction, and π-π interactions. Overall, these results imply that low-cost and green nanofiber carbon aerogels may be promising adsorbents for the remediation of antibiotic-contaminated wastewater. The materials prepared from natural and readily available bacterial cellulose can adsorb antibiotics efficiently, which provides a reference for the development of adsorbent materials using natural substances.
EXPERIÊNCIA DO PROFESSOR NA IDENTIFICAÇÃO DO BULLYING NA ESCOLA
Authors: Marques Bottós Aretuza , Alves Costa Adriana , José Ísper Garbin Artênio , Adas Saliba Tânia , Adas Saliba Garbin Cléa
Published: September 2021

Introdução: Atualmente, o bullying é uma das principais formas de violência nas escolas, podendo provocar severos danos psicológicos e físicos em suas vítimas. A inserção do professor tem sido apontada como o fator crucial no enfrentamento e na resolução da problemática. Objetivo: Objetivou-se neste estudo, verificar a experiência do professor no reconhecimento do bullying e na sala de aula. Metodologia: Trata-se de um estudo transversal descritivo, composto por 73 professores que atuam com crianças na faixa etária de 10 a 12 anos, de um total de 138 educadores, de 22 escolas da rede pública estadual de um município do interior do estado de São Paulo. Para a coleta de dados, aplicou-se um questionário misto e para a interpretação dos resultados, utilizou-se a frequência e análise de conteúdo. Resultados: Do total de participantes, 83,5% tinham até 10 anos de trabalho como professor e 72,6% afirmou já ter presenciado episódios de discriminação e/ou violência entre os adolescentes na sala de aula, onde 86,3% salientou sentir tristeza, indignação e revolta diante de tais atos. Em relação à atitude que tomariam diante ao bullying, prevaleceu o diálogo como sendo a medida mais eficaz, ressaltando ainda que o incentivo a participação dos pais na vida dos filhos favoreceria a melhora do comportamento. Conclusões: Conclui-se que os educadores identificam o bullying na sala de aula e se sentem tristes diante da situação, considerando o diálogo e a participação da família na vida das crianças como fatores essenciais no combate ao problema.
ASSISTÊNCIA AO PRÉ-NATAL NO RIO GRANDE DO NORTE: ACESSO E QUALIDADE DO CUIDADO NA ATENÇÃO BÁSICA
Authors: Farias De Almeida Cinthia Palloma , Da Silva José Adailton , Freire de Araújo Juliana Iscarlaty , Brito de Azevedo Ádilla Conceição
Published: September 2021

Introdução:A assistência ao pré-natal adequada e de qualidade, é primordial para redução da mortalidade materna e infantil, além disso, tem o propósito de preparar a gestante para o parto e o puerpério. Objetivo:Esta pesquisa tem como objetivo descrever a adequação da assistência pré-natal no Rio Grande do Norte, a partir dos resultados do módulo III - Entrevista com o usuário na Unidade Básica de Saúde, do Programa de Melhoria do Acesso e da Qualidade da Atenção Básica.Metodologia:Trata-se de um estudo descritivo, analítico, com abordagem quantitativa, no qual a amostra foi composta por 189 mulheres no 1º Ciclo e 304 mulheres no 2º Ciclo. Resultados:Os resultados obtidos foram satisfatórios para maioria das variáveis avaliadas, consideradas como essenciais pelo Ministério da Saúde quanto ao acompanhamento do pré-natal, demonstrando também, efetividade dos programas do SUS.Conclusões:Espera-se que este estudo possa incentivar estratégias no âmbito da Atenção Básica, para valorizar e ampliar os princípios do SUS, sempre trabalhando o usuário em sua completude.
AVALIAÇÃO DA MORBIDADE HOSPITALAR E MORTALIDADE POR NEOPLASIA: 2015 - 2019
Authors: Santos Ferreira Tainara Lorena dos , Barbosa Neta Silva Rita Xavier , Andrade Fábia Barbosa de , Morais Thiffany Nayara Bento de
Published: September 2021

Introdução: Atualmente, um dos maiores problemas de saúde pública trata-se das doenças crônicas não transmissíveis, que têm gerado elevado número de mortes prematuras. Objetivo: Analisar a morbidade hospitalar e mortalidade na população com faixa-etária entre 10 e 59 anos no Brasil, no período de 2015 a 2019. Metodologia: Trata-se de um estudo quantitativo, do tipo observacional, cujo método de investigação caracteriza-se por um estudo epidemiológico ecológico de série temporal em uma série histórica dos últimos cinco anos (2015-2019) disponíveis em meados de Abril de 2021, e extraídos da base nacional de domínio público do Ministério da Saúde intitulada DATASUS - Departamento de Informática do SUS. Resultados: Observou-se que a distribuição da taxa de mortalidade por neoplasia, por 100.000 habitantes por Causa CID-BR-10 em população com faixa etária entre 10 e 59 anos, se deu por Neoplasia maligna da mama, como segunda causa de mortes por Neoplasia no quinquênio, seguido por Neoplasia maligna da traquéia, dos brônquios e dos pulmões, Neoplasia maligna do cólon, do reto e do ânus, Neoplasia maligna do estômago e Neoplasia maligna das meninges, do encéfalo e de outras partes do sistema nervoso central. Quanto a taxa de morbidade hospitalar a partir das causas de maior prevalência observa-se que o Leiomioma do útero apresenta maior média no período observado (39.454), mediana de 38.88 e desvio padrão de 2.03, seguido por outras neoplasias in situ e neoplasias benignas e neoplasias de comportamento incerto ou desconhecido com média em 31.724, mediana 30.88 e desvio padrão 0.66. Conclusões: A análise de indicadores da saúde por neoplasias demonstra a tendencia crescente no quinquênio da morbidade hospitalar e mortalidade. De modo que se destacam que sejam alvo de maiores pesquisas e atenções.
Social and institutional presence of the Heads of Government of the Americas on Social Media
Authors: Mendonça Lucas Dejard Moreira , Santos Adriano Madureira dos , Junior Harold Dias de Mello , Paulino Rita de Cássia Romeiro , Figueiredo Karla , Costa Fernando Augusto Ribeiro , Seruffo Marcos César da Rocha
Published: September 2021

This article examined the personal profiles of the Heads of Government of countries in South/North America and how they communicated with their audiences on institutional measures to contain COVID-19. Analyses were carried out on data collected from Twitter from November-2019 to November-2020. This study includes: i)quantitative analysis, measuring categories and emphases in the communication of tweets, retweets, likes, and comments on matters relevant to the pandemic; ii)qualitative analysis that allowed evaluating speeches to identify political interference and the effectiveness of communication at critical moments of the pandemic. It was possible to infer that each president has his singularities and understanding about Social Media’s use as a more direct communication tool with his audience. It was also found that successful communication is not directly proportional to the volume of messages on Twitter, but to socio-political aspects and institutional leadership that can make a difference in Social Media in combating COVID-19.
Role of the Bone Marrow Microenvironment in Drug Resistance of
Hematological Malignances
Authors: Hosseini Alireza , Hamblin Michael R. , Mirzaei Hamed , Mirzaei Hamid R.
Published: September 2021

The unique features of the tumor microenvironment (TME) govern the biological
properties of many cancers, including hematological malignancies. TME factors can
trigger an invasion and protect against drug cytotoxicity by inhibiting apoptosis and activating
specific signaling pathways (e.g. NF-ΚB). TME remodeling is facilitated due to
the high self-renewal ability of the bone marrow. Progressing tumor cells can alter some
extracellular matrix (ECM) components which act as a barrier to drug penetration in the
TME. The initial progression of the cell cycle is controlled by the MAPK pathway
(Raf/MEK/ERK) and Hippo pathway, while the final phase is regulated by the PI3K/Akt
/mTOR and WNT pathways. This review summarizes the main signaling pathways involved
in drug resistance (DR) and some mechanisms by which DR can occur in the bone
marrow. The relationship between autophagy, endoplasmic reticulum stress, and cellular
signaling pathways in DR and apoptosis is covered in the TME.
A Survey for Predicting ATP Binding Residues of Proteins Using
Machine Learning Methods
Authors: Yang Yu-He , Wang Jia-Shu , Yuan Shi-Shi , Liu Meng-Lu , Su Wei , Lin Hao , Zhang Zhao-Yue
Published: September 2021

Protein-ligand interactions are necessary for majority protein functions. Adenosine-
5’-triphosphate (ATP) is one such ligand that plays vital role as a coenzyme in
providing energy for cellular activities, catalyzing biological reaction and signaling.
Knowing ATP binding residues of proteins is helpful for annotation of protein function
and drug design. However, due to the huge amounts of protein sequences influx into databases
in the post-genome era, experimentally identifying ATP binding residues is costineffective
and time-consuming. To address this problem, computational methods have
been developed to predict ATP binding residues. In this review, we briefly summarized
the application of machine learning methods in detecting ATP binding residues of proteins.
We expect this review will be helpful for further research.
Anti-Proliferative Potential of Fluorinated Curcumin Analogues:
Experimental and Computational Analysis and Review of the Literature
Authors: Hatamipour Mahdi , Hadizadeh Farzin , Jaafari Mahmoud Reza , Khashyarmanesh Zahra , Sathyapalan Thozhukat , Sahebkar Amirhossein
Published: September 2021

Background:

Curcuminoids, flavoring, and coloring agents in food have potent
antioxidant, anti-tumor activity, and anti-inflammatory effects. However, they are rapidly
metabolized to lesser active metabolites. Therefore, various studies have been conducted
to synthesize new and stable curcumin analogues with enhanced therapeutic activity.

Methods:

Fluorinated curcumin compounds (2a-2f) were synthesized by Knoevenagel
condensation between fluorobenzaldehydes (1a-1f) with curcumin. Fluorinated demethoxycurcumin
(3a) was synthesized by condensation between demethoxycurcumin and
3,4-difluorobenzaldehyde (1f). The structures of these compounds were confirmed by FTIR,
1H-NMR, 13C-NMR, 19FNMR, and mass spectroscopy. Antiproliferative activities of
these synthetic compounds were evaluated against breast cancer cells (4T1), melanoma
cancer cells (B16F10), and normal cell lines (NIH 3T3) using MTT assay. The interaction
of curcumin, 2f and 3a with several proteins (1HCL, 2ZOQ, 3D94, 5EW3, 4WA9,
1XKK, 6CCY) was investigated. The structural preservation of the epidermal growth factor
receptor (EGFR) was investigated by molecular dynamics simulation.

Results:

The spectroscopic data obtained confirmed the proposed structure of fluorinated
analogues. The results showed that compounds 2f and 3a inhibited cancer cells proliferation
significantly more than other compounds. Compounds 2f and 3a showed the highest
affinity and lowest binding energy with EGFR. The binding energies were -7.8, -10, and -
9.8 kcal/mol for curcumin, 2f and 3a with EGFR, respectively. The molecular docking results
demonstrated that compounds 2f and 3a were firmly bound in a complex with EGFR
via the formation of a hydrogen bond.

Conclusion:

In summary, we found that fluorinated demethoxycurcumin and fluorinated
curcumin induces cancer cell death and binds to EGFR with high affinity.
Therapeutic Targeting of Inflammatory Pathways with Emphasis on
NLRP3 Inflammasomes by Natural Products: A Novel Approach for
the Treatment of Inflammatory Eye Diseases
Authors: Soliman Amro M. , Sim Ru Hui , Das Srijit , Mahakkanukrauh Pasuk
Published: September 2021

There is an increase in the incidence of inflammatory eye diseases worldwide.
Several dysregulated inflammatory pathways, including the NOD-like receptor protein 3
(NLRP3) inflammasome, have been reported to contribute significantly to the pathogenesis
and progression of ophthalmic diseases. Although the available allopathic/ conventional
medicine has demonstrated effectiveness in managing eye diseases, there is an ongoing
global demand for alternative therapeutics with minimal adverse drug reactions,
easy availability, increase in patient compliance, and better disease outcomes. Therefore,
several studies are investigating the utilization of natural products and herbal formulations
in impeding inflammatory pathways, including the NLRP3 inflammasome, in order to
prevent or manage eye diseases. In the present review, we highlight the recently reported
inflammatory pathways with special emphasis on NLRP3 Inflammasomes involved in the
development of eye diseases. Furthermore, we present a variety of natural products and
phytochemicals that were reported to interfere with these pathways and their underlying
mechanisms of action. These natural products represent potential therapeutic applications
for the treatment of several inflammatory eye diseases.
Role of Adenosine Receptors in Rare Neurodegenerative Diseases with
Motor Symptoms
Authors: Beltran-Beltran Vicent , Benetó Noelia , Lapeña-Luzón Tamara , Rodríguez Laura R. , Pallardó Federico V. , Gonzalez-Cabo Pilar
Published: September 2021

:

The approval of istradefylline, an adenosine 2A receptor (A2AR) antagonist, as an addon
treatment in adult patients with Parkinson’s disease by the Food and Drug Administration (FDA)
and European Medicines Agency (EMA), is the latest proof of the importance of the adenosinergic
system in the nervous system. Adenosine is an endogenous purine nucleoside with a role as a modulator
of both neurotransmission and the inflammatory response. As such, the expression pattern of
the 4 adenosine receptors (A1R, A2AR, A2BR and A3R) and the extracellular adenosine levels
have attracted great interest in the pathogenesis and possible treatment of rare neurodegenerative
diseases with motor symptoms. These include Huntington’s Disease (HD), Amyotrophic Lateral
Sclerosis (ALS), Multiple Sclerosis (MS), Restless Legs Syndrome (RLS) and Machado-Joseph
Disease (MJD, also known as spinocerebellar ataxia type 3, SCA3). In this review, we shall focus
on the role of the different adenosine receptor subtypes in the development and possible treatment
of the aforementioned rare neurodegenerative diseases with motor symptoms using the currently
available data. The last section discusses the possibility of a role for the adenosine receptors in the
treatment of other rare diseases based on the available molecular pathology knowledge.
CD155: A Key Receptor Playing Diversified Roles
Authors: Nandi Shyam Sundar , Gohil Trupti , Sawant Sonali Ankush , Lambe Upendra Pradeep , Ghosh Sudip , Jana Snehasis
Published: September 2021

:

Cluster of differentiation (CD155), formerly identified as poliovirus receptor
(PVR) and later as immunoglobulin molecule, is involved in cell adhesion, proliferation,
invasion and migration. It is a surface protein expressed mostly on normal and
transformed malignant cells. The expression of the receptor varies based on the origin of
tissue. The expression of the protein is determined by factors involved in the sonic
hedgehog pathway, Ras-MEK-ERK pathway and during stressful conditions like DNA
damage response. The protein uses an alternate splicing mechanism, producing four
isoforms, two being soluble (CD155β and CD155γ) and two being transmembrane
protein (CD155α and CD155δ). Apart from being a viral receptor, researchers have
identified CD155 to play important roles in cancer research and the cell signaling field.
The receptor is recognized as a biomarker for identifying cancerous tissue. The receptor
interacts with molecules involved in the cells’ defense mechanism. The immunesurveillance
role of CD155 is being deciphered to understand the mechanistic approach
it utilizes as an onco-immunologic molecule. CD155 is a non-MHC-I ligand which helps
in identifying non-self to NK cells via an inhibitory TIGIT ligand. The TIGIT–CD155
pathway is a novel MHC-I-independent education mechanism for cell tolerance and
activation of NK cells. The receptor also has a role in metastasis of cancer and
transendothelial mechanism. In this review, the authors discuss the virus-host interaction
that occurs via a single transmembrane receptor, the poliovirus infection pathway, which
is being exploited as a therapeutic pathway. The oncolytic virotherapy is now a
promising modality for curing cancer.
Network Pharmacology Analysis of Molecular Mechanism of Curcuma longa L.
Extracts Regulating Glioma Immune Inflammatory Factors: Implications for
Precise Cancer Treatment
Authors: Li Hui , Li Yongwei
Published: September 2021

Introduction: :

Curcuma longa L. has been associated with different antioxidant, antiinflammatory,
bactericidal and anticancer effects, but the mechanisms of the effects are not yet
clearly understood. This study aimed to investigate the key targets and the effect of potential molecular
mechanisms of Curcuma longa L. extracts on glioma using different network pharmacology
analysis approaches.

Methods:

The components of Curcuma longa were extracted by gas chromatography-mass spectrometry
(GC-MS), and the active components related to the occurrence and development of glioma
were determined by traditional Chinese medicine systems pharmacology database and analysis platform
(TCMSP) database, and the same targets of the active components and glioma were screened
by network pharmacology approach. Then, the protein’s function and regulatory pathway of the
common targets were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes
(KEGG) pathway enrichment analyses. The protein’s action and regulatory pathway of the
common targets were analyzed with the Cytoscape package using the Search Tool for the Retrieval
of Interacting Genes/Proteins (STRING) database to construct the target interaction network through
which the key targets were identified.

Results :

GC-MS combined with TCMSP database was used to identify the active components related
to the occurrence and development of glioma in Curcuma longa. Finally, we identified the active
components 1-(1,5-Dimethyl-4-hexenyl)-4-methyl benzene and Zingiberene. At the same time,
190 target genes of Curcuma longa extracts on glioma were obtained using the Venn diagram. The
results of GO analysis showed that the biological processes involved included a response to stimulation,
metabolic process, inflammatory process, cell differentiation, and regulation of biological processes.
KEGG analysis showed that the PI3K-Akt signaling pathway, MAPK signaling pathway,
Th17 cell differentiation, and proteoglycan pathway might be involved in cancer. Further analyses
showed that the IL-17 signaling pathway and Interleukin-4 and interleukin-13 signaling were involved
in the inflammatory pathway. The analysis of key nodes showed that GSK3B, MAPK14,
HSP90AA1, MAPK3 and MAPK8 were IL-17 signaling pathways, while HIF1A and JAK3 were
Interleukin-4 and interleukin-13 signaling pathways.

Conclusion:

Curcuma longa extracts can regulate the occurrence and development of glioma by
regulating the immune-inflammatory responses.
A Novel Multicolor-thresholding Auto-detection Method to Detect the Location
and Severity of Inflammation in Confirmed SARS-COV-2 Cases using
Chest X-Ray Images
Authors: Abbas Mohamed A. , Alqahtani Mohammed S. , Alqahtani Ali M. , Alshahrani Mohammad Y. , Alkulib Abdulhadi J. , Alelyani Magbool A. , Almarhaby Awad M.
Published: September 2021

Objectives:

Since late 2019, Coronavirus Disease 2019 (COVID-19) has spread around
the world. It has been determined that the disease is very contagious and can cause acute respiratory
distress (ARD). Medical imaging has the potential to help identify, detect, and quantify the severity
of this infection. This work seeks to develop a novel auto-detection technique for verified
COVID-19 cases that can detect aberrant alterations in traditional X-ray pictures.

Methods:

Nineteen separately colored layers were created from X-ray scans of patients diagnosed
with COVID-19. Each layer represents objects that have a similar contrast and can be represented
by a single color. In a single layer, objects with similar contrasts are formed. A single color image
was created by extracting all the objects from all the layers. The prototype model could recognize a
wide range of abnormal changes in the image texture based on color differentiation. This was true
even when the contrast values of the detected unclear abnormalities varied slightly.

Results:

The results indicate that the proposed novel method is 91% accurate in detecting and grading
COVID-19 lung infections compared to the opinions of three experienced radiologists evaluating
chest X-ray images. Additionally, the method can be used to determine the infection site and
severity of the disease by categorizing X-rays into five severity levels.

Conclusion:

By comparing affected tissue to healthy tissue, the proposed COVID-19 auto-detection
method can identify locations and indicate the severity of the disease, as well as predict where
the disease may spread.
A comparative clinical study of Amavatavidhwansa Rasa
and Simhanaada Guggulu in the management of
Amavata w.s.r. to Rheumatoid Arthritis
Authors: Jagadale Vaibhav A. , Shrinivasarao M. , Mohan G. Vinay , Dharmannavar Girish , Rudrapuri M. B.
Published: September 2021

Amavata is the most challenging disease for the medical science, as it causes severe intolerable pain
and severe deformities making the patient disable and bedridden. As it is the disease of Rasavaha
Srotas and having several features similar to Rheumatoid Arthritis, Amavata can be correlated with
Rheumatoid Arthritis (RA). Amavata is the outcome of Agnidushti, Amotpatti and Sandhivikrutti, with
the passage of the time most of the dietary habits, changing lifestyle and environment have been
contributing to the disease, the risk factor include age, gender, genetics and environmental
exposures. Hence Amavata have became a challenge to the human race. Management of the disease
is merely insufficient in other system of medicine, in such condition disease which continues to pose
challenge to the physician as well as for patients due to severe morbidity and crippling nature. So
patients are continuously looking for the treatment from Ayurved to overcome this challenge. It also
shows extra articular features like bodyache, stiffness etc. many research have been carried out to
solve this clinical enigma.The therapy which normalizes Agni metabolizes Ama and regulates Vata and
maintain healthy Sandhi and Sandhistha Shelshma will be the supreme one for this disease. The
formulations of Amavatavidhvansa Rasa and Simhanaada Guggula is indicated, especially in treating
the Amavata.
Anti-Oxidant effects of Swarnamakshika Bhasma : A Experimental Study
Authors: AS Shrikanth , Jadar P. G.
Published: September 2021

Shodhana of Swarnamakshika carried out by Bharjana in Eranda Tila. Marana of Swarnamakshika by finely powdered Shudda Swarnamakshika was taken in a Khalvayantra. Then equal quantity of Shudda Gandhaka was added and triturated together till they become homogenous. To this mixture 100ml of Jambhira Rasa was added triturated well till it becomes semisolid consistency. The paste were made into shape of Chakrikas weighing 25gm and 8cm uniformly and kept for drying. Subjecting into 5 required number of Varahaputas. The present day lifestyle and food habits have increased the production of free radicals. These cytotoxic free radicals not only raise the oxidative stress but also play an important role in the immune-system dysfunction due to which the mankind is prone to various major ailments and it is now proved that diseases like Prameha, Pandu, Vatavyadhi etc. are free radical mediated ones. To tackle these free radicals our body needs antioxidants. An antioxidant is a molecule which is capable of inhibiting the oxidation of other molecules. Oxidation reactions can produce free radicals which in turn start chain reactions that damage cells. Antioxidants terminate these chain reactions by removing free radical intermediates and inhibit other oxidation reactions. Many herbals drugs and compound herbal preparations have been screened for their antioxidant and immuno-modulatory properties but still there is a need for effective antioxidants. This dearth and also the fact that Swarnamakshika is being used in treating many of the free radical mediated diseases prompted us to take the present study which aims to validate the Antioxident effect of Swarnamakshika Bhasma scientifically and explain its probable mode of action at the cellular level.
Knowledge attitude and practice of Peya among practitioners of Ayurveda
Authors: PV Shinitha
Published: September 2021

Ahara plays an important role in the maintenance of health and cure of diseases. Various dietetic preparations are explained in Ayurveda under Pathya Kalpana. Among this Pathya Kalpana, Peya is most commonly used preparation. No much study is undergone on this topic. Peya is beneficial in healthy and diseased. Peya is Satmya to people living in southern parts of India. So medicines can be administered by adding it with Peya. In classics, there are various diseases in which Peya have been recommended. On administering Oushada Siddha Peya in these conditions Peya does its action as well as exhibits the properties of Dravyas with which it is processed. It cures disease and at the same time nourishes Dhathus. A KAP survey was conducted as a part of study among the Ayurvedic practitioners. Majority of practitioners were found to administer classical Peya Yogas. Utility of Peya have been extended to other diseases, which are not mentioned in classical ayurvedic text books. This proves that Peya can be administered depending on the condition of patient as well as stage of disease. It was observed from the study that 78.0% practitioners had good knowledge regarding Peya and more than 50.0% had positive attitude towards this treatment modality. But only 46.0% practitioners adopted Oushada Siddha Peya in their practice.
To assess the importance of Nidana Parivarjan in the treatment of Urdhvag Amlapitta with Guduchi Satva
Authors: Kulkarni Parag Vishwas , Thamake Mangesh Jagannath
Published: September 2021

Amlapitta is one of the leading clinical conditions in today’s speedy lifestyle. Present study focuses on this burning issue and its causes mentioned in Ayurved texts and actual causes observed in day to day life. Importance and benefits of Nidanparivarjan over only symptomatic treatment was assessed during this study. Amlapitta cases were diagnosed according to Ayurvedic texts and classified into two groups. One group was administered with only treatment and the other group was advised Nidanparivarjan along with the treatment. At the end of the study, it was found that the group with Nidanparivarjan was more benefited as compared to only treatment group. This clearly states that Ayurvedic method of finding the particular Hetu of the disease and practice of avoiding those Hetu; i.e. Nidanparivarjan leads to better results and complete eradication and prevention of the disease; thus serving the main principle of Ayurved science - Prevention is better than Cure.
Clinical study to evaluate the effectiveness of Gavakshi Moola (Citrullus colocynthis) Draava with Ksheera in Kamala (hepatocellular jaundice)
Authors: . Madhavi , Jadhav Lakshmiprasad L.
Published: September 2021

Hepatocellular jaundice is a sign that usually accompanies diseases of liver, the organ that detoxifies metabolites, synthesizes proteins, produces biochemicals necessary for digestion, decomposes red blood cells and produces hormones,[1] hence is constantly under the risk of various diseases. Causes of hepatocellular jaundice are numerous with the most common being viral hepatitis, alcohol and drug toxicity. Kamala described among the Pittaja Nanatmaja Vyadhi has Haridra Varna of Netra, Twak, Nakha, Anana, Mutra as the cardinal sign, hence analogous to jaundice. The administration of Gavakshimoola Draava for 3 days is described in the management of Kamala. A clinical trial was conducted on 15 subjects and the results obtained were statistically analysed. Statistically significant reduction of Lakshana of Kamala and serum levels of bilirubin with p-value less than 0.05 was noted.
Pharmaceutical evaluation of Haridra Khanda tablet
Authors: Sonare Makrand A. , Samantaray Manoj Kumar
Published: September 2021

Haridra Khanda is unique classical formulation indicated in Udarda, Shitapitta, Kotha. (Urticarial rashes) Khanda or Granules are a comparatively unusual means of administering drugs that possess an unpleasant taste. Haridra Khanda is classical Ayurvedic medicine and available market. Keeping the issue of palatability and invention of patient friendly dosage form in mind, the efforts was made for preparation of tablet out of classical Ayurvedic formulation - Haridra Khanda. The preparation of Haridra Khanda granules were made by standard operative procedure.Binding agents were added to Haridra Khanda . Haridra Khanda was added to mass mixer to ensure homogeneity and easy mixing of all binding agents. And later this mixture was subjected to single punch tablet machine for preparation of 1000 mg tablet. All the Analytical parameters were passed by the Haridra Khanda tablets. Physician can prescribed the tablets to the patients which feel the powdered dosage uncomfortable. Depending on the Roga and Rogibala, tablets of various sizes can be punched and used clinically. This can work more efficiently in pediatric practice.
Pharmacognostical, phytochemical and HPTLC evaluation of Erandamuladi Kwatha Churna - A polyherbal formulation for pharmaceutical standardization
Authors: N. Swathi , Thakar Anup B. , C.R. Harisha , Shukla V.J.
Published: September 2021

Introduction: Erandamuladi Kwatha is mentioned in Ayurveda classics as a therapeutic formulation of Basti mainly to treat Trika-prishta Shoola (low back ache). The most common disorder which affects the movement of leg particularly in the productive period of life is low backache. Erandamuladi Kwatha used in Basti contains 15 drugs in which most of the drugs are having Ushna Veerya and are Vatakaphahara in nature. Materials and Methods: Yavakuta Choorna of Erandamuladi Kwatha was evaluated for their pharmacognostic and pharmaceutical analysis. Results and Discussion: Pharmacognostic study showed the presence of contents such as starch grains of Kantakari, rosette crystal of Rasna, pollen grain of Atibala etc. Physico-chemical analysis showed that the loss on drying 7.74%, Ash value 6.78%, Water soluble extract 20.12%, Alcohol soluble extract 4.3%, pH 7.2. Conclusion: From the study, data developed can be espoused for laying down the standards of Erandamuladi Kwatha.
Pharmaceutico analytical study of Shodhita Shilajatu
Authors: Elias Arya , Baragi Pramod C. , Hadimur Kashinath , Patil K. A. , Rahimbi Khazi
Published: September 2021

Background: Shilajatu or Adrija is one of the Maharasa, which is considered as a wonderful medicine in Ayurveda. It is named as it comes out of the stones heated by the sun in summer in the form of thick blackish exudation having many shades. Since it contain stone, mud, wood, sand and various physical and metallic impurities, Shodhana (Purification) of Shilajatu is a mandatory procedure. It has been used as a prime ingredient in many formulations mainly for Prameha, Sotha, Pandu Roga, Kshaya, Swasa, Pliha Vrudhi, Jwara, Agnimandya, Apasmara, etc. Objectives: Shodhana of Ashudha Shilajatu and Physico chemical analysis of Shodhita Shilajatu. Materials and Methods: Bhringaraja Swarasa for Shodhana of Shilajatu. Results:It took 8 days for completion of Shilajatu Shodhana. XRD Analysis report indicates that the sample Shilajatu was Amorphous material. Conclusion: Total yield of Shodhita Shilajatu was 99.6%. The Sample of Shilajatu was found to be Amorphous material in XRD Analysis hence crystal structure was not identified.
Pharmaceutico-Analytical study of Karanjadi Taila and its conversion into cream
Authors: Sheth Sachin S. , Asore Gangaprasad R. , Darade Kiran Sudhakar
Published: September 2021

Karanjadi Taila is medicated oil used in Ayurveda for Indralupta (Alopecia). Indralupta comes under Kshudra Roga which is characterized by loss of hair it can be correlated with Alopecia areata which is having chief complaint of hair loss on body especially on scalp. The aim of the present study is to do physic-chemical standards for the above Taila and its conversion into Karanjadi Taila cream. These two formulations have a special importance from pharmaceutical point of view when compared to usual Tailas or cream. In present article, we are trying to study analytical results of Karanjadi Taila w.s.r. to Karanjadi Taila cream.
Clinical study to evaluate the effectiveness of Narikela Lavana, Navasadara Yuktha Yavakshara in comparision with Surya and Navasadara Paneeya Kshara in the management of Cholelithiasis
Authors: . Nagaratna , Masalekar Srinivas
Published: September 2021

Cholelithiasis is a crystalline concretion formed within the gall bladder by accretion of bile components. Cholelithiasis can be considered as Pittashaya Ashmari, but there is no direct reference of this condition available in Ayurveda. In Ayurveda the effective treatment is Paneeya Kshara. Surya and Navasadara Paneeya Kshara is standard one and which is highly effective treatment in the management of Cholelithiasis but, persisting pain, presence of calculi has limited in its use. To overcome the lacunas present study has been carried out. This study was conducted at SJIIM Hospital Bengaluru and total of 40 patients were randomly allotted into two groups namely Group A with trial drug i.e. 2grams each of Narikela Lavana, Navasadara, Yava Kshara orally with Jala once daily in empty stomach in the morning, every day for 28 days and Group B with control drug i.e. 2grams of Surya and Navasadara Paneeya Kshara orally with Narikela Jala once daily in empty stomach in the morning, every day for 28 days. Assessment was made on Subjective and Objective parameters. Observations were made before the treatment and on 15th day and 30th day to know the efficacy of the treatment. The combination of Narikela Lavana, Navasadara Yuktha Yava Kshara showed a positive result.
Pharmaceutical standardization of Palashakshara
Authors: Rao I Ganapathi , Halli Chandrakanth M. , Kamthikar Subhod
Published: September 2021

Standardization of herbal drugs is essential to certify their quality and purity. Kshara (alkaline substance) of Palasha (Butea monosperma) is an important constituent in many Ayurvedic formulations, but its standard manufacturing process (SMP) is not attempted till date. This study is aimed to establish SMP for Palashakshara. In pharmaceutical process; generally, the sediments of ash obtained at the end of washes will be discarded. However, in the study, we attempted to wash the sediments repeatedly by adding water to extract more Kshara. Palasha was collected from the local area and authenticated. Kshara was prepared by following standard methods and the preliminary physicochemical profile was developed. It is observed that the ash yields Kshara even in the consecutive washes. First wash yielded 21.23% w/w Kshara, while the second and third washes yielded 9.38% w/w and 4.76% w/w, respectively. Repeated washes yield more Kshara. Hence, it is advocated to wash the ashes repeatedly. As the findings are encouraging, similar experiments can be extended to all other Kshara preparations.
Clinical Study of Nirgundi Ghana Vati with Nirgundi Patra Panda Sweda in the management on Amavata
Authors: Sundi Shakuntala , Shukla V. D. , Munzni Rajan Nelson , Khalkho Sushma
Published: September 2021

Today as man is climbing the step of success, he is moving away from health abnormal food habits, style of living, greed, anger have become a part of his life. The sedentary life style has given birth to number of diseases. Amavata is one of the challenging diseases for the physicians due to its chronicity, incurability, complications and morbidity. Amavata (Rheumatoid arthritis) the term desires from the words as “Ama ” and “Vata” the word Ama is the condition which in various ailments in system due to its toxic effect. The Ama when combines with Vatadosha and occupies in Shleshmasthana (Asthi Sandhi) results painful disease „Amavata‟ The disease is characterized by various features like Sandhishoola in the nature of Toda, swelling inability of joints movements etc. In this research work 16 patients were registered, these patients were given Nirgundi Ghan Vati in the doses of 500gm two Vati three times a day for 30 days, along with Nirgundi Patra Pinda Sweda in 28 days. Results show that significant decrease in the symptoms of Amavata after treatment regimen.
Pre- and post- Covid-19 Outreach Experiences at Marshall University Libraries
Authors: Mollette Sarah , Johnson Kelli
Published: September 2021

This article will provide insight into how MU Libraries’ cross-departmental system has evolved over the years, and how the recent finalization of their Outreach Plan led to a successful transition to online outreach during the COVID pandemic. Specifically, the authors will address: the history of library outreach at the university; the formation of the Outreach Librarian position; the audit the Outreach librarian performed on the library’s practices; the creation of an Outreach committee and subsequent Outreach Plan guide; and, how the library adapted their approach during the Covid-19 pandemic of 2020.