bluuebunny/crossref_metadata_2025 huggingface dataset:
CasTabDetectoRS: Cascade Network for Table Detection in Document Images with Recursive Feature Pyramid and Switchable Atrous Convolution
Authors: Hashmi Khurram Azeem , Pagani Alain , Liwicki Marcus , Stricker Didier , Afzal Muhammad Zeshan
Published: October 2021

Table detection is a preliminary step in extracting reliable information from tables in scanned document images. We present CasTabDetectoRS, a novel end-to-end trainable table detection framework that operates on Cascade Mask R-CNN, including Recursive Feature Pyramid network and Switchable Atrous Convolution in the existing backbone architecture. By utilizing a comparativelyightweight backbone of ResNet-50, this paper demonstrates that superior results are attainable without relying on pre- and post-processing methods, heavier backbone networks (ResNet-101, ResNeXt-152), and memory-intensive deformable convolutions. We evaluate the proposed approach on five different publicly available table detection datasets. Our CasTabDetectoRS outperforms the previous state-of-the-art results on four datasets (ICDAR-19, TableBank, UNLV, and Marmot) and accomplishes comparable results on ICDAR-17 POD. Upon comparing with previous state-of-the-art results, we obtain a significant relative error reduction of 56.36%, 20%, 4.5%, and 3.5% on the datasets of ICDAR-19, TableBank, UNLV, and Marmot, respectively. Furthermore, this paper sets a new benchmark by performing exhaustive cross-datasets evaluations to exhibit the generalization capabilities of the proposed method.
Effect of High-Temperature Stress on Plant Physiological Traits and Mycorrhizal Symbiosis in Maize Plants
Authors: Mathur Sonal , Agnihotri Richa , Sharma Mahaveer P. , Reddy Vangimalla R. , Jajoo Anjana
Published: October 2021

Increasing high temperature (HT) has a deleterious effect on plant growth. Earlier works reported the protective role of arbuscular mycorrhizal fungi (AMF) under stress conditions, particularly influencing the physiological parameters. However, the protective role of AMF under high-temperature stress examining physiological parameters with characteristic phospholipid fatty acids (PLFA) of soil microbial communities including AMF has not been studied. This work aims to study how high-temperature stress affects photosynthetic and below-ground traits in maize plants with and without AMF. Photosynthetic parameters like quantum yield of photosystem (PS) II, PSI, electron transport, and fractions of open reaction centers decreased in HT exposed plants, but recovered in AMF + HT plants. AMF + HT plants had significantly higher AM-signature 16:1ω5cis neutral lipid fatty acid (NLFA), spore density in soil, and root colonization with lower lipid peroxidation than non-mycorrhizal HT plants. As a result, enriched plants had more active living biomass, which improved photosynthetic efficiency when exposed to heat. This study provides an understanding of how AM-mediated plants can tolerate high temperatures while maintaining the stability of their photosynthetic apparatus. This is the first study to combine above- and below-ground traits, which could lead to a new understanding of plant and rhizosphere stress.
Characterization of Fungal FAD-Dependent AA3_2 Glucose Oxidoreductases from Hitherto Unexplored Phylogenetic Clades
Authors: Wijayanti Sudarma Dita , Sützl Leander , Duval Adèle , Haltrich Dietmar
Published: October 2021

The CAZy auxiliary activity family 3 (AA3) comprises FAD-dependent enzymes belonging to the superfamily of glucose-methanol-choline (GMC) oxidoreductases. Glucose oxidase (GOx; EC 1.1.3.4) and glucose dehydrogenase (GDH; EC 1.1.5.9) are part of subfamily AA3_2 and catalyze the oxidation of β-D-glucose at its anomeric carbon to D-glucono-1,5-lactone. Recent phylogenetic analysis showed that AA3_2 glucose oxidoreductases can be grouped into four major clades, GOx I and GDH I–III, and in minor clades such as GOx II or distinct subclades. This wide sequence space of AA3_2 glucose oxidoreductases has, however, not been studied in detail, with mainly members of GOx I and GDH I studied biochemically or structurally. Here, we report the biochemical characterization of four fungal glucose oxidoreductases from distinct, hitherto unexplored clades or subclades. The enzyme from Aureobasidium subglaciale, belonging to the minor GOx II clade, showed a typical preference for oxygen and glucose, confirming the correct annotation of this clade. The other three enzymes exhibited strict dehydrogenase activity with different substrate specificities. GDH II from Trichoderma virens showed an almost six-fold higher catalytic efficiency for maltose compared to glucose. The preferred substrate for the two GDH III enzymes from Rhizoctonia solani and Ustilago maydis was gentiobiose, a β(1→6) disaccharide, as judged from the catalytic efficiency. Overall, the newly studied AA3_2 glucose oxidoreductases showed a much broader substrate spectrum than the archetypal GOx from Aspergillus niger, which belongs to clade GOx I.
Improved Personalised Neuroendocrine Tumours’ Diagnosis Predictive Power by New Receptor Somatostatin Image Processing Quantification
Authors: Stolniceanu Cati Raluca , Moscalu Mihaela , Azoicai Doina , Tamba Bogdan , Volovat Constantin , Grierosu Irena , Ionescu Teodor , Jalloul Wael , Ghizdovat Vlad , Gherasim Roxana , Volovat Simona , Wang Feng , Fu Jingjing , Moscalu Roxana , Matovic Milovan , Stefanescu Cipriana
Published: October 2021

Although neuroendocrine tumours (NETs) are intensively studied, their diagnosis and consequently personalised therapy management is still puzzling due to their tumoral heterogeneity. In their theragnosis algorithm, receptor somatostatin scintigraphy takes the central place, the diagnosis receptor somatostatin analogue (RSA) choice depending on laboratory experience and accessibility. However, in all cases, the results depend decisively on correct radiotracer tumoral uptake quantification, where unfortunately there are still unrevealed clues and lack of standardization. We propose an improved method to quantify the biodistribution of gamma-emitting RSA, using tissular corrected uptake indices. We conducted a bi-centric retrospective study on 101 patients with different types of NETs. Three uptake indices obtained after applying new corrections to areas of interest drawn for the tumour and for three reference organs (liver, spleen and lung) were statistically analysed. For the corrected pathological uptake indices, the results showed a significant decrease in the error of estimating the occurrence of errors and an increase in the diagnostic predictive power for NETs, especially in the case of lung-referring corrected index. In conclusion, these results support the importance of corrected uptake indices use in the analysis of 99mTcRSA biodistribution for a better personalised diagnostic accuracy of NETs patients.
Perfluoroalkyl Carboxylic Acids Interact with the Human Bile Acid Transporter NTCP
Authors: Ruggiero Melissa J. , Miller Haley , Idowu Jessica Y. , Zitzow Jeremiah D. , Chang Shu-Ching , Hagenbuch Bruno
Published: October 2021

Na+/taurocholate cotransporting polypeptide (NTCP) is important for the enterohepatic circulation of bile acids, which has been suggested to contribute to the long serum elimination half-lives of perfluoroalkyl substances in humans. We demonstrated that some perfluoroalkyl sulfonates are transported by NTCP; however, little was known about carboxylates. The purpose of this study was to determine if perfluoroalkyl carboxylates would interact with NTCP and potentially act as substrates. Sodium-dependent transport of [3H]-taurocholate was measured in human embryonic kidney cells (HEK293) stably expressing NTCP in the absence or presence of perfluoroalkyl carboxylates with varying chain lengths. PFCAs with 8 (PFOA), 9 (PFNA), and 10 (PFDA) carbons were the strongest inhibitors. Inhibition kinetics demonstrated competitive inhibition and indicated that PFNA was the strongest inhibitor followed by PFDA and PFOA. All three compounds are transported by NTCP, and kinetics experiments revealed that PFOA had the highest affinity for NTCP with a Km value of 1.8 ± 0.4 mM. The Km value PFNA was estimated to be 5.3 ± 3.5 mM and the value for PFDA could not be determined due to limited solubility. In conclusion, our results suggest that, in addition to sulfonates, perfluorinated carboxylates are substrates of NTCP and have the potential to interact with NTCP-mediated transport.
Well-Posedness and Stability Results for a Nonlinear Damped Porous–Elastic System with Infinite Memory and Distributed Delay Terms
Authors: Moumen Abdelkader , Ouchenane Djamel , Bouhali Keltoum , Altayeb Yousif
Published: October 2021

In the present paper, we consider an important problem from the application perspective in science and engineering, namely, one-dimensional porous–elastic systems with nonlinear damping, infinite memory and distributed delay terms. A new minimal conditions, placed on the nonlinear term and the relationship between the weights of the different damping mechanisms, are used to show the well-posedness of the solution using the semigroup theory. The solution energy has an explicit and optimal decay for the cases of equal and nonequal speeds of wave propagation.
Anticholinergic Burden of Geriatric Ward Inpatients
Authors: Wilczyński Krzysztof , Gorczyca Marta , Gołębiowska Jagna , Szewieczek Jan
Published: October 2021

Background and Objectives: Anticholinergic drug use in the pharmacotherapy of elderly persons is common despite the increased risk of side effects. We examined the prevalence of anticholinergic drug use and total anticholinergic drug burden among patients admitted to an acute care geriatric ward in Poland. Materials and Methods: Cross-sectional study of 329 subjects hospitalized at the geriatric ward. Patient condition was assessed with a comprehensive geriatric assessment. The Anticholinergic Cognitive Burden (ACB) scale was used to estimate the total anticholinergic load. Results: Mean patient age was 79.61 ± 6.82 years. 40.73% of them were burdened with at least one anticholinergic drug. The clinically significant anticholinergic burden was observed in 13.98% of subjects. Patients with dementia, risk of falls, and severe disability had significantly higher total ACB scores compared to other groups. The receiver operating characteristics (ROC) curve revealed that the total ACB score ≥ 1 was significantly associated with dementia and the risk of falls. Total ACB score ≥ 2 was significantly associated with severe disability. Conclusions: Patients admitted to an acute care geriatric ward had an anticholinergic cognitive burden score comparable to other patient populations. We found associations at both low and elevated levels of anticholinergic burden with dementia and risk of falls. At elevated anticholinergic burden levels, we found associations with severe disability. Despite recommendations against the use of anticholinergics in older adults these medications are still commonly prescribed. Further study is necessary to define the characteristics of anticholinergic medication most closely associated with negative outcomes in elderly populations.
Epidemiology of Musculoskeletal Injuries in Adult Athletes: A Scoping Review
Authors: Gimigliano Francesca , Resmini Giuseppina , Moretti Antimo , Aulicino Milena , Gargiulo Fiorinda , Gimigliano Alessandra , Liguori Sara , Paoletta Marco , Iolascon Giovanni
Published: October 2021

Background and Objectives: Sport-related musculoskeletal injuries (MSK-Is) are a common health issue in athletes that can lead to reduced performance. The aim of this scoping review was to synthetize available evidence on injury incidence rates (IIRs), types, and sites that affect the musculoskeletal (MSK) system of adult athletes. Materials and Methods: We performed a scoping review on the Pubmed database limiting our search to 33 Olympic sports. Results: We identified a total of 1022 papers, and of these 162 were examined in full for the purpose of this review. Archery was the sport with the highest risk of injuries to the upper extremities, marathons for the lower extremities, and triathlon and weightlifting for the body bust. In the majority of the sports examined, muscle/tendon strain and ligament sprain were the most common MSK-Is diagnoses, while athletics, karate, and football were the sports with the highest IIRs, depending on the methods used for their calculations. Conclusions: Our scoping review highlighted the general lack and dishomogeneity in the collection of data on MSK-Is in athletes.
The Epidemiological Patterns of Hepatitis C in Lithuania: Changes in Surveillance from 2005 to 2018
Authors: Grubyte Samanta , Urboniene Jurgita , Nedzinskiene Laura , Jancoriene Ligita
Published: October 2021

Background and Objectives: Viral hepatitis C infection is an important public health concern worldwide because it is one of the major global causes of death and morbidity. The early identifi-cation of infected people, together with the provision of proper treatment, are the key strategies used in preventing HCV infection. However, data regarding the epidemiological patterns of hep-atitis C in Lithuania are limited. The aim of this research was to evaluate trends in acute HCV cases registered via the national surveillance system in Lithuania during 2005–2018. Materials and Methods: Incidence rates were calculated for data, stratified by gender, age group (0–24, 25–54, 55–74, and 75+), place of residence (urban or rural), and the Lithuanian county where the case was recorded. The crude incidence rate of hepatitis C was defined as the number of new infec-tions per 100,000 people during a one-year time period. A linear regression was applied to evalu-ate IR trends during the period of 2005–2018. Results: From 2005 to 2018, 572 cases of acute hepa-titis C were registered, and the incidence rate ranged from 2.03 cases per 100,000 people in 2005 to 0.55 in 2016. A statistically significant decreasing trend in the incidence rate was found during the study period (p < 0.0001). Almost 63% of the acute HCV infections recorded via the national surveillance system were in individuals aged from 25 to 54 years. Conclusions: Being male, aged between 25 and 34 years, and living in the city might be important factors for understanding the epidemiological patterns of HCV in Lithuania. Although the number of HCV cases recorded in Lithuania is decreasing, our country has one of the highest IRs compared to other European countries. This shows that a new approach to hepatitis C virus screening strategies is needed.
Metabolomics Reveals Heterogeneity in the Chemical Composition of Green and White Spears of Asparagus (A. officinalis)
Authors: Pegiou Eirini , Zhu Qingrui , Pegios Paraskevas , De Vos Ric C. H. , Mumm Roland , Hall Robert D.
Published: October 2021

Green and white asparagus are quite different crops but can be harvested from the same plant. They have distinct morphological differences due to their mode of cultivation and they are characterised by having contrasting appearance and flavour. Significant chemical differences are therefore expected. Spears from three varieties of both green and white forms, harvested in two consecutive seasons were analysed using headspace GC-MS and LC-MS with an untargeted metabolomic workflow. Mainly C5 and C8 alcohols and aldehydes, and phenolic compounds were more abundant in green spears, whereas benzenoids, monoterpenes, unsaturated aldehydes and steroidal saponins were more abundant in white ones. Previously reported key asparagus volatiles and non-volatiles were detected at similar or not significantly different levels in the two asparagus types. Spatial metabolomics revealed also that many volatiles with known positive aroma attributes were significantly more abundant in the upper parts of the spears and showed a decreasing trend towards the base. These findings provide valuable insights into the metabolome of raw asparagus, the contrasts between green and white spears as well as the different chemical distributions along the stem.
Batch Transfer Printing of Small-Size Silicon Nano-Films with Flat Stamp
Authors: Cao Wenping , Liu Guochang , Miao Jinwei , Zhang Guojun , Cui Jiangong , Yang Yuhua , He Changde , Zhang Wendong , Wang Renxin
Published: October 2021

Silicon nano-film is essential for the rapidly developing fields of nanoscience and flexible electronics, due to its compatibility with the CMOS process. Viscoelastic PDMS material can adhere to Si, SiO2, and other materials via intermolecular force and play a key role in flexible electronic devices. Researchers have studied many methods of transfer printing silicon nano-films based on PDMS stamps with pyramid microstructures. However, only large-scale transfer printing processes of silicon nano-films with line widths above 20 μm have been reported, mainly because the distribution of pyramid microstructures proposes a request on the size of silicon nano-films. In this paper, The PDMS base to the curing agent ratio affects the adhesion to silicon and enables the transfer, without the need for secondary alignment photolithography, and a flat stamp has been used during the transfer printing, with no requirement for the attaching pressure and detaching speed. Transfer printing of 20 μm wide structures has been realized, while the success rate is 99.3%. The progress is promising in the development of miniature flexible sensors, especially flexible hydrophone.
Anisotropic Differences in the Thermal Conductivity of Rocks: A Summary from Core Measurement Data in East China
Authors: Wang Yibo , Wang Zhuting , Shi Lin , Rong Yuwei , Hu Jie , Jiang Guangzheng , Wang Yaqi , Hu Shengbiao
Published: October 2021

The study of thermal conductivity anisotropy is of great importance for more accurate heat flow calculations, geodynamic studies, development and utilization of hot dry rock, and simulation of heat transfer in geological reservoirs of nuclear waste, and so on. To study the thermal conductivity anisotropy of rocks, 1158 cores from 60 boreholes in East China were tested for thermal conductivity, including thermal conductivity values parallel to (λ∥) and perpendicular to (λ⊥) structural planes of basalt, mudstones, gneisses, sandstones, carbonates, evaporites, and metamorphic rocks. The thermal conductivity anisotropy is not obvious for sand, clay, and evaporate, and the average anisotropic factors of 1.19 ± 0.22, 1.18 ± 0.17, and 1.18 ± 0.17 for tuff/breccia, granitoid and contact metamorphic rocks, respectively, indicate that these three rocks have strong anisotropy characteristics. Finally, the effect of thermal conductivity anisotropy on heat flow is studied and discussed in detail, showing that the results of thermal conductivity tests have a significant effect on the calculation of heat flow and thermal structure, and the data show that a deviation of about 10% in thermal conductivity causes a deviation of about 11% in heat flow, which may lead to a misperception of deep thermal structure studies. The regular and anisotropic characteristics of thermal conductivity of various rocks in Eastern China obtained in this paper can provide parameter support for projects such as heat flow calculations, thermal structure studies, and geothermal resource development and utilization.
Application of the Fractal Dimension Calculation Technique to Determine the Shape of Selected Monchepluton Intrusion Crystals (NE Fennoscandia)
Authors: Huber Miłosz , Stępniewska Klaudia
Published: October 2021

Thirty-eight samples of minerals from Paleoproterozoic Layered PGE Intrusion Monchepluton, located in NE Fennoscandia, were tested. An automated computational technique was used which involved counting the sides superimposed on vectorized graphics using separated crystal boundaries. The results were obtained for olivine, orthopyroxene, clinopyroxene, and plagioclase. On this basis, an interpretation of the mineral box fractal dimension was made, along with an interpretation of its nature in the rock in which it was found. The performed calculations were applied to the sampling positions, and maps of changes in fractal dimensions were prepared. The nature of the minerals studied was correlated with the type of rocks present in Monchepluton. Then, the fractal dimensions were scaled to a percentage scale determining the mean value for the euhedral crystal as 100%, and a map was obtained representing the advancement of secondary processes after summing these data for all four investigated minerals. This method was analyzed and its advantages and limitations shown.
Chemosensory Profile of South Tyrolean Pinot Blanc Wines: A Multivariate Regression Approach
Authors: Poggesi Simone , Dupas de Matos Amanda , Longo Edoardo , Chiotti Danila , Pedri Ulrich , Eisenstecken Daniela , Robatscher Peter , Boselli Emanuele
Published: October 2021

A multivariate regression approach based on sensory data and chemical compositions has been applied to study the correlation between the sensory and chemical properties of Pinot Blanc wines from South Tyrol. The sensory properties were identified by descriptive analysis and the chemical profile was obtained by HS-SPME-GC/MS and HPLC. The profiles of the most influencing (positively or negatively) chemical components have been presented for each sensory descriptor. Partial Least Square Regression (PLS) and Principal Component Regression (PCR) models have been tested and applied. Visual (clarity, yellow colour), gustatory (sweetness, sourness, saltiness, bitterness, astringency, and warmness) and olfactory (overall intensity, floral, apple, pear, tropical fruit, dried fruit, fresh vegetative, spicy, cleanness, and off-odours) descriptors have been correlated with the volatile and phenolic profiles, respectively. Each olfactory descriptor was correlated via a PCR model to the volatile compounds, whereas a comprehensive PLS2 regression model was built for the correlation between visual/gustatory descriptors and the phenolic fingerprint. “Apple” was the olfactory descriptor best modelled by PCR, with an adjusted R2 of 0.72, with only 20% of the validation samples falling out of the confidence interval (α = 95%). A PLS2 with 6 factors was chosen as the best model for gustatory and visual descriptors related to the phenolic compounds. Finally, the overall quality judgment could be explained by a combination of the calibrated sensory descriptors through a PLS model. This allowed the identification of sensory descriptors such as “olfactory intensity”, “warmness”, “apple”, “saltiness”, “astringency”, “cleanness”, “clarity” and “pear”, which relevantly contributed to the overall quality of Pinot Blanc wines from South Tyrol, obtained with two different winemaking processes and aged in bottle for 18 months.
Nitrogen as a Probe Molecule for the IR Studies of the Heterogeneity of OH Groups in Zeolites
Authors: Kuterasiński Łukasz , Gackowski Mariusz , Podobiński Jerzy , Rutkowska-Zbik Dorota , Datka Jerzy
Published: October 2021

One of the methods of IR studies of the heterogeneity of Si–OH–Al groups in zeolites is the investigation of the frequency shift of the band of free OH bands restored upon the adsorption of ammonia and subsequent desorption at increasing temperatures. We extended this method by following the shift of the band of the OH group interacting by hydrogen bonding with nitrogen. The advantage of nitrogen, compared with CO, which has been commonly used as a probe molecule in studies on hydrogen bonding, is that for nitrogen the frequency shift is smaller than for CO and therefore there is no overlapping of shifted OH band with the bands of ammonium ions. For zeolites NaHY, HMFI, and HBEA, the frequency shift of IR bands of both free and hydrogen-bonded Si–OH–Al with the increase of ammonia desorption temperature evidences the heterogeneity of these hydroxyls. On the other hand, in zeolite HFAU of Si/Al = 31, Si–OH–Al were found to be homogeneous. Heterogeneity of OH groups may be explained both by the presence of Si–OH–Al of various number of Al near the bridge and of Si–OH–Al of various geometry.
Consumption of Sinlek Rice Drink Improved Red Cell Indices in Anemic Elderly Subjects
Authors: Lerttrakarnnon Peerasak , Kusirisin Winthana , Koonyosying Pimpisid , Flemming Ben , Utama-ang Niramon , Fucharoen Suthat , Srichairatanakool Somdet
Published: October 2021

Iron fortifications are used for the treatment of iron-deficiency anemia; however, iron dosing may cause oxidative damage to the gut lumen. Thai Sinlek rice is abundant in iron and contains phytochemicals. We aimed at evaluating the effect of an iron-rice (IR) hydrolysate drink (100 mL/serving) on neurological function, red cell indices and iron status in elders. Healthy elderly subjects were divided into three non-anemic groups and one anemic group. The non-anemic groups consumed one WR (2 mg iron/serving) and two IR drinks (15 and 27 mg iron/serving) (groups A, B and D, respectively), while the anemic group consumed one IR drink (15 mg iron serving) (group C) every day for 30 days. There were no significant differences in the MMSE Thai 2002 and PHQ9 test scores for members of all groups, while the nutrition scores and body weight values of group D subjects were significantly increased. Hemoglobin (Hb) and mean corpuscular hemoglobin concentrations increased significantly only in group C. Serum iron and transferrin saturation levels tended to increase in group A, while these levels were decreased in members of group C. Serum antioxidant activity levels were increased in all groups, and were highest in group C. Thus, consumption of an IR drink for 15 days functioned to increase Hb and antioxidant capacity levels in anemic elders.
Isolation of Live Leukocytes from Human Inflammatory Muscles
Authors: Coudert Jerome D. , McLeish Emily , Sooda Anuradha , Slater Nataliya , Beer Kelly , Paramalingam Shereen , Lamont Phillipa J. , Needham Merrilee
Published: October 2021

In inflammatory myopathies, the self-reactive immune cells involved in muscle aggression have been studied mostly using histological assessment of muscle biopsy sections; this methodology provides the advantage of visualizing and identifying cells within the tissue, but it does not allow further investigation. To gain access to live and isolated cells, many studies utilized blood samples; however, in the absence of biological tools to discriminate the leukocytes associated with the autoimmune process from those that emerged from responses against pathogens, the information observed on circulating immune cells often lacks in specificity, and thus result interpretation may prove difficult. In order to selectively retrieve self-reactive immune cells, we developed a protocol to isolate live leukocytes from human muscle biopsies, which allows for further analysis using a large range of methodologies. The protocol uses enzymatic digestion to release live leukocytes from freshly collected skeletal muscle samples, followed by filtration and separation of the leukocytes from the myocytes by density gradient centrifugation. The isolated cells can be submitted immediately to various analysis strategies to characterize ex vivo the specific cellular and molecular mechanisms responsible for self-directed immune muscle aggression or may be placed in culture for expansion.
Optical Properties of Plasma Dimer Nanoparticles for Solar Energy Absorption
Authors: Sun Chunlei , Qin Caiyan , Zhai Han , Zhang Bin , Wu Xiaohu
Published: October 2021

Plasmonic nanofluids have excellent optical properties in solar energy absorption and have been widely studied in solar thermal conversion technology. The absorption of the visible region of solar energy by ordinary metal nanoparticles is usually limited to a narrow resonance band, so it is necessary to enhance the coupling effect of nanoparticles in the visible spectrum region to improve absorption efficiency. However, it is still a difficult task to improve solar energy absorption by adjusting the structure and performance of nanoparticles. In this paper, a plasma dimer Ag nanoparticle is proposed to excite localized surface plasmon resonance (LSPR). Compared with an ordinary Ag nanoparticle in the visible region, the plasmonic Ag dimer nanoparticle produces more absorption peaks and broader absorption bands, which can broaden solar energy absorption. By analyzing the electromagnetic field of the nanoparticle, the resonance mode of the plasma dimer is discussed. The effects of the geometric dimensions of the nanoparticle and the embedding of two spheres on the optical properties are studied. In addition, the effects of a trimer and its special structure on the optical properties are also analyzed. The results show that the proposed plasma dimer Ag nanoparticle has broad prospects for application in solar thermal conversion technology.
Nitrogen-Doped Reduced Graphene Oxide Supported Pd4.7Ru Nanoparticles Electrocatalyst for Oxygen Reduction Reaction
Authors: Park Gil-Ryeong , Jo Seung Geun , Varyambath Anuraj , Kim Jeonghyun , Lee Jung Woo
Published: October 2021

It is imperative to design an inexpensive, active, and durable electrocatalyst in oxygen reduction reaction (ORR) to replace carbon black supported Pt (Pt/CB). In this work, we synthesized Pd4.7Ru nanoparticles on nitrogen-doped reduced graphene oxide (Pd4.7Ru NPs/NrGO) by a facile microwave-assisted method. Nitrogen atoms were introduced into the graphene by thermal reduction with NH3 gas and several nitrogen atoms, such as pyrrolic, graphitic, and pyridinic N, found by X-ray photoelectron spectroscopy. Pyridinic nitrogen atoms acted as efficient particle anchoring sites, making strong bonding with Pd4.7Ru NPs. Additionally, carbon atoms bonding with pyridinic N facilitated the adsorption of O2 as Lewis bases. The uniformly distributed ~2.4 nm of Pd4.7Ru NPs on the NrGO was confirmed by transmission electron microscopy. The optimal composition between Pd and Ru is 4.7:1, reaching −6.33 mA/cm2 at 0.3 VRHE for the best ORR activity among all measured catalysts. Furthermore, accelerated degradation test by electrochemical measurements proved its high durability, maintaining its initial current density up to 98.3% at 0.3 VRHE and 93.7% at 0.75 VRHE, whereas other catalysts remained below 90% at all potentials. These outcomes are considered that the doped nitrogen atoms bond with the NPs stably, and their electron-rich states facilitate the interaction with the reactants on the surface. In conclusion, the catalyst can be applied to the fuel cell system, overcoming the high cost, activity, and durability issues.
3D Food Printing: Principles of Obtaining Digitally-Designed Nourishment
Authors: Varvara Rodica-Anita , Szabo Katalin , Vodnar Dan Cristian
Published: October 2021

Three-dimensional printing (3DP) technology gained significance in the fields of medicine, engineering, the food industry, and molecular gastronomy. 3D food printing (3DFP) has the main objective of tailored food manufacturing, both in terms of sensory properties and nutritional content. Additionally, global challenges like food-waste reduction could be addressed through this technology by improving process parameters and by sustainable use of ingredients, including the incorporation of recovered nutrients from agro-industrial by-products in printed nourishment. The aim of the present review is to highlight the implementation of 3DFP in personalized nutrition, considering the technology applied, the texture and structure of the final product, and the integrated constituents like binding/coloring agents and fortifying ingredients, in order to reach general acceptance of the consumer. Personalized 3DFP refers to special dietary necessities and can be promising to prevent different non-communicable diseases through improved functional food products, containing bioactive compounds like proteins, antioxidants, phytonutrients, and/or probiotics.
Intake Estimation of Phytochemicals in a French Well-Balanced Diet
Authors: Amiot Marie-Josèphe , Latgé Christian , Plumey Laurence , Raynal Sylvie
Published: October 2021

Phytochemicals contribute to the health benefits of plant-rich diets, notably through their antioxidant and anti-inflammatory effects. However, recommended daily amounts of the main dietary phytochemicals remain undetermined. We aimed to estimate the amounts of phytochemicals in a well-balanced diet. A modelled diet was created, containing dietary reference intakes for adults in France. Two one-week menus (summer and winter) were devised to reflect typical intakes of plant-based foods. Existing databases were used to estimate daily phytochemical content for seven phytochemical families: phenolic acids, flavonoids (except anthocyanins), anthocyanins, tannins, organosulfur compounds, carotenoids, and caffeine. The summer and winter menus provided 1607 and 1441 mg/day, respectively, of total polyphenols (phenolic acids, flavonoids, anthocyanins, and tannins), the difference being driven by reduced anthocyanin intake in winter. Phenolic acids, flavonoids (including anthocyanins), and tannins accounted for approximately 50%, 25%, and 25% of total polyphenols, respectively. Dietary carotenoid and organosulfur compound content was estimated to be approximately 17 and 70 mg/day, respectively, in both seasons. Finally, both menus provided approximately 110 mg/day of caffeine, exclusively from tea and coffee. Our work supports ongoing efforts to define phytochemical insufficiency states that may occur in individuals with unbalanced diets and related disease risk factors.
Constant Voltage Iontophoresis Technique to Deliver Terbinafine via Transungual Delivery System: Formulation Optimization Using Box–Behnken Design and In Vitro Evaluation
Authors: Nair Anroop B. , Al-Dhubiab Bandar E. , Shah Jigar , Gorain Bapi , Jacob Shery , Attimarad Mahesh , Sreeharsha Nagaraja , Venugopala Katharigatta N. , Morsy Mohamed A.
Published: October 2021

Topical therapy of antifungals is primarily restricted due to the low innate transport of drugs through the thick multi-layered keratinized nail plate. The objective of this investigation was to develop a gel formulation, and to optimize and evaluate the transungual delivery of terbinafine using the constant voltage iontophoresis technique. Statistical analysis was performed using Box–Behnken design to optimize the transungual delivery of terbinafine by examining crucial variables namely concentration of polyethylene glycol, voltage, and duration of application (2–6 h). Optimization data in batches (F1–F17) demonstrated that chemical enhancer, applied voltage, and application time have influenced terbinafine nail delivery. Higher ex vivo permeation and drug accumulation into the nail tissue were noticed in the optimized batch (F8) when compared with other batches (F1–F17). A greater amount of terbinafine was released across the nails when the drug was accumulated by iontophoresis than the passive counterpart. A remarkably higher zone of inhibition was observed in nails with greater drug accumulation due to iontophoresis, as compared to the passive process. The results here demonstrate that the optimized formulation with low voltage iontophoresis could be a viable and alternative tool in the transungual delivery of terbinafine, which in turn could improve the success rate of topical nail therapy in onychomycosis.
Facile Synthesis of Gallium (III)-Chitosan Complexes as Antibacterial Biomaterial
Authors: Akhtar Muhammad Asim , Hadzhieva Zoya , Ilyas Kanwal , Ali Muhammad Saad , Peukert Wolfgang , Boccaccini Aldo R.
Published: October 2021

Even though antibiotic treatment remains one of the most common tools to handle bacterial infections, the excessive antibiotic concentration at the target site may lead to undesired effects. Aiming at the fabrication of antibiotic-free biomaterials for antibacterial applications, in this work, we propose the synthesis of gallium (III)—chitosan (Ga (III)-CS) complexes with six different gallium concentrations via an in situ precipitation method. Fourier Transform infrared spectroscopy indicated the chelation of chitosan with Ga (III) by peak shifts and changes in the relative absorbance of key spectral bands, while energy-dispersive X-ray spectroscopy indicated the homogenous distribution of the metal ions within the polymer matrix. Additionally, similar to CS, all Ga (III)-CS complexes showed hydrophobic behavior during static contact-angle measurements. The antibacterial property of the complexes against both Gram-negative and Gram-positive bacteria was positively correlated with the Ga (III) concentration. Moreover, cell studies confirmed the nontoxic behavior of the complexes against the human osteosarcoma cell line (MG-63 cells) and mouse embryonic fibroblasts cell line (MEFs). Based on the results of this study, new antibiotic-free antibacterial biomaterials based on Ga (III)-CS can be developed, expanding the scope of CS applications in the biomedical field.
Choosing an Effective Compatibilizer for a Virgin HDPE Rich-HDPE/PP Model Blend
Authors: Karaagac Erdal , Koch Thomas , Archodoulaki Vasiliki-Maria
Published: October 2021

The most widely used commodity polymers in the rigid packaging industry are polypropylene (PP) and high-density polyethylene (HDPE). For example, blow molding grade of HDPE as a bottle and injection molding grade of PP as a cap are often used to produce detergent bottles. Therefore, the recycled HDPE bottles from post-consumer waste include PP as a contaminant originated from PP bottle caps. To simulate mechanical recycling of bottle waste, the mechanical properties of HDPE-rich-HDPE/PP virgin model blend were studied. For compatibilization, ethylene-based olefin block copolymer, propylene-based olefin block copolymer, ethylene propylene random copolymer, and styrene-butadiene-styrene triblock copolymer were chosen as potential compatibilizer candidates. Contact angle measurements, morphological analysis, adhesion tests of compatibilizer candidates to polymer blend components and the tensile as well as tensile impact properties of the ternary blends were studied. It was found that the ethylene-based olefin block copolymer was the most effective compatibilizer resulting in a return of mechanical properties to those of neat vHDPE due to its ability to encapsulate dispersed vPP particles in a vHDPE matrix (core-shell morphology) and the best adhesion to polymer blend components.
In Vitro Models for the Development of Peripheral Nerve Conduits, Part I: Design of a Fibrin Gel-Based Non-Contact Test
Authors: De Stefano Paola , Federici Angelica Silvia , Draghi Lorenza
Published: October 2021

Current clinical strategies to repair peripheral nerve injuries draw on different approaches depending on the extent of lost tissue. Nerve guidance conduits (NGCs) are considered to be a promising, off-the-shelf alternative to autografts when modest gaps need to be repaired. Unfortunately, to date, the implantation of an NGC prevents the sacrifice of a healthy nerve at the price of suboptimal clinical performance. Despite the significant number of materials and fabrication strategies proposed, an ideal combination has not been yet identified. Validation and comparison of NGCs ultimately requires in vivo animal testing due to the lack of alternative models, but in the spirit of the 3R principles, a reliable in vitro model for preliminary screening is highly desirable. Nevertheless, more traditional in vitro tests, and direct cell seeding on the material in particular, are not representative of the actual regeneration scenario. Thus, we have designed a very simple set-up in the attempt to appreciate the relevant features of NGCs through in vitro testing, and we have verified its applicability using electrospun NGCs. To this aim, neural cells were encapsulated in a loose fibrin gel and enclosed within the NGC membrane. Different thicknesses and porosity values of two popular polymers (namely gelatin and polycaprolactone) were compared. Results indicate that, with specific implementation, the system might represent a useful tool to characterize crucial NGC design aspects.
Strand-Morphology-Based Process Optimization for Extrusion-Based Silicone Additive Manufacturing
Authors: Ma Dingyifei , Tian Xiaoqing , Wang Shengyi , Liu Haijun , Chen Shan , Han Jiang , Xia Lian
Published: October 2021

In the silicone material extrusion (MEX) process, product profile error and performance defects are common problems due to changes in strand shape. A process optimization method considering strand morphology, denoted as SMO, which allows adjustment of the strand shape by adjusting process parameters during the printing process is presented. The relation between process parameters (extrusion speed, moving speed, nozzle height, and nozzle radius) and the geometric parameters (strand width and strand height) of the cross-section, as well as the relationship between strand spacing, layer height, and process parameters in no void constraint is discussed and verified. SMO was utilized to produce specimens with tunable strand width and strand height. Tensile tests and profile scans were performed to compare SMO with other methods to verify its feasibility. Specimens fabricated using the SMO method have up to a 7% increase in tensile strength, up to a 10% reduction in processing time, and about a 60% reduction in strand height error over unused ones. The results show that the SMO method with adjustable strand width can effectively balance efficiency and mechanical properties compared to uniform infill, and the SMO method with adjustable strand height can provide higher accuracy compared to uniform strand height. The proposed method is validated and improves the efficiency and accuracy of silicone MEX.
Rheological Properties of Aqueous Sodium Alginate Slurries for LTO Battery Electrodes
Authors: Toigo Christina , Kracalik Milan , Bradt Elke , Pettinger Karl-Heinz , Arbizzani Catia
Published: October 2021

Rheological properties of electrode slurries have been intensively studied for manifold different combinations of active materials and binders. Standardly, solvent-based systems are under use, but a trend towards water-based electrode manufacturing is becoming more and more important. The different solvent is beneficial in terms of sustainability and process safety but is also accompanied by some disadvantages such as extraction of residual humidity and a higher complexity concerning slurry stability. Li4Ti5O12 (LTO) active material provides good long-term stability and can be processed in aqueous solutions. Combining the LTO active material with sodium alginate (SA) as a promising biobased polymer binder reveals good electrochemical properties but suffers from bad slurry stability. In this work, we present a comprehensive rheological study on material interactions in anode slurries consisting of LTO and SA, based on a complex interaction of differentially sized materials. The use of two different surfactants—namely, an anionic and non-ionic one, to enhance slurry stability, compared with surfactant-free slurry.
Spatial Assessment of Community Resilience from 2012 Hurricane Sandy Using Nighttime Light
Authors: Xu Jinwen , Qiang Yi
Published: October 2021

Quantitative assessment of community resilience is a challenge due to the lack of empirical data about human dynamics in disasters. To fill the data gap, this study explores the utility of nighttime lights (NTL) remote sensing images in assessing community recovery and resilience in natural disasters. Specifically, this study utilized the newly-released NASA moonlight-adjusted SNPP-VIIRS daily images to analyze spatiotemporal changes of NTL radiance in Hurricane Sandy (2012). Based on the conceptual framework of recovery trajectory, NTL disturbance and recovery during the hurricane were calculated at different spatial units and analyzed using spatial analysis tools. Regression analysis was applied to explore relations between the observed NTL changes and explanatory variables, such as wind speed, housing damage, land cover, and Twitter keywords. The result indicates potential factors of NTL changes and urban-rural disparities of disaster impacts and recovery. This study shows that NTL remote sensing images are a low-cost instrument to collect near-real-time, large-scale, and high-resolution human dynamics data in disasters, which provide a novel insight into community recovery and resilience. The uncovered spatial disparities of community recovery help improve disaster awareness and preparation of local communities and promote resilience against future disasters. The systematical documentation of the analysis workflow provides a reference for future research in the application of SNPP-VIIRS daily images.
The Relationship between Satellite-Derived Vegetation Indices and Live Weight Changes of Beef Cattle in Extensive Grazing Conditions
Authors: Pearson Christie , Filippi Patrick , González Luciano A.
Published: October 2021

The live weight (LW) and live weight change (LWC) of cattle in extensive beef production is associated with pasture availability and quality. The remote monitoring of pastures and cattle LWC can be achieved with a combination of satellite imagery and walk-over-weighing (WoW) stations. The objective of the present study is to determine the association, if any, between vegetation indices (VIs) (pasture availability) and the LWC of beef cattle in an extensive breeding operation in Northern Australia. The study also tests a suite of VIs along with variables such as rainfall and Julian day to predict the LWC of breeding cows. The VIs were calculated from Sentinel-2 satellite imagery over a 2-year period from a paddock with 378 cattle. Animal LW was measured remotely using a weighing scale at the water point. The relationship between VIs, the LWC, and LW was assessed using linear mixed-effects regression models and random forest modelling. Findings demonstrate that all VIs calculated had a significant positive relationship with the LWC and LW (p < 0.001). Machine learning predictive modelling showed that the LWC of breeding cows could be predicted from VIs, Julian day, and rainfall information, with a Lin’s Concordance Correlation Coefficient of 0.62 when using the leave-one-month-out cross-validation. The LW and LWC were greater during the wet season when VIs were higher compared to the dry season (p < 0.001). Results suggest that the remote monitoring of pasture availability, the LWC and LW is possible under extensive grazing conditions. Further, the use of VIs and other readily available data such as rainfall can be used to predict the LWC of a breeding herd in extensive conditions. Such information could be used to increase the productivity and land management in extensive beef production. The integration of these data streams offers great potential to improve the monitoring, management, and productivity of grazing or cropping enterprises.
TRS: Transformers for Remote Sensing Scene Classification
Authors: Zhang Jianrong , Zhao Hongwei , Li Jiao
Published: October 2021

Remote sensing scene classification remains challenging due to the complexity and variety of scenes. With the development of attention-based methods, Convolutional Neural Networks (CNNs) have achieved competitive performance in remote sensing scene classification tasks. As an important method of the attention-based model, the Transformer has achieved great success in the field of natural language processing. Recently, the Transformer has been used for computer vision tasks. However, most existing methods divide the original image into multiple patches and encode the patches as the input of the Transformer, which limits the model’s ability to learn the overall features of the image. In this paper, we propose a new remote sensing scene classification method, Remote Sensing Transformer (TRS), a powerful “pure CNNs → Convolution + Transformer → pure Transformers” structure. First, we integrate self-attention into ResNet in a novel way, using our proposed Multi-Head Self-Attention layer instead of 3 × 3 spatial revolutions in the bottleneck. Then we connect multiple pure Transformer encoders to further improve the representation learning performance completely depending on attention. Finally, we use a linear classifier for classification. We train our model on four public remote sensing scene datasets: UC-Merced, AID, NWPU-RESISC45, and OPTIMAL-31. The experimental results show that TRS exceeds the state-of-the-art methods and achieves higher accuracy.