bluuebunny/crossref_metadata_2025 huggingface dataset:
Host Risk Factors for Tuberculosis
Authors: Asgharzadeh Vahid , Seyyed Rezaei Seyyed Amin , Asgharzadeh Mohammad , Rashedi Jalil , Samadi Kafil Hossein , Jalaei Nobari Hossein , Khalili Ahmad Ali , Raeisi Mortaza , Ozma Mahdi Asghari , Mahdavi Poor Behroz
Published: September 2024

Tuberculosis (TB) spreads through droplets that contain Mycobacterium tuberculosis (Mtb) and can infect susceptible people. Due to different risk factors, people have different susceptibility ranges towards TB. The risk factors are classified into three main groups, includ-ing bacterial, environmental, and host factors. Literature review reveals that the most important host risk factors are aging, male gender, genetics, epigenetics, having an impaired immune system, diabetes, malignancy, malnutrition, anemia, and pregnancy. The risk factors contribute to the increase in TB cases through inflammation, increased contact with TB patients, disrup-tion of immune genes, changes in gene expression, increased activity of Mtb, damage to cellu-lar immunity, reactivation of Latent TB Infection (LTBI), increased susceptibility to TB, com-promised immunity, and changes in the proportion of T cell subgroups, respectively. Therefore, identification of the infection source and high-risk people and timely treatment of the patients can reduce TB mortality and help control the disease.
Green Synthesis of Iron Nanoparticles (FeNPs) using Aqueous Extract of Murraya koenigii Leaves: Synthesis Mechanism, Characterization Process and Antibacterial Activity
Authors: Samarawickrama Rumesh , Wijayapala Samudrika , Fernando Annesly Nandana
Published: September 2024

Introduction:

Green synthesis is the method of producing metal and metal oxide nanoparticles
from the extraction of plant materials. This study aims to synthesize iron nanoparticles (FeNPs)
using an aqueous extract of Murraya koenigii leaves as an eco-friendly approach and subsequently
characterize the synthesized FeNPs to understand their structural, morphological, compositional and
optical properties.

Methods:

The aqueous extract of Murraya koenigii leaves and 0.1M ferric chloride solution were
combined at room temperature in a 1:2 volume ratio. The synthesized FeNPs were characterized
using analysis methods of Scanning Electron Microscope (SEM), Energy Dispersive X-ray (EDX),
X-ray diffraction (XRD), Fourier Transform Infrared (FTIR), UV-visible (UV-vis) and Tacu plot.

Results:

SEM images discovered that the particles were in the nanoscale range and their morphology
appeared spherical shape. The EDX study was used to identify the composition of the elements of
synthesized FeNPs. The crystal structure of the synthesised FeNPs was shown in the XRD spectrum.
The FTIR spectrum showed many distinctive bands and the bands revealed active components for
functional groups in the synthesized FeNPs. The UV-vis spectrum revealed an absorbance peak
range of 240-310 nm for FeNP formation with a maximal peak at 273 nm. The band gap energy of
the synthesized FeNPs was found to be 2.07 eV using the Tauc plot method. Also, the synthesized
FeNPs exhibited a significant antibacterial effect against bacterial pathogens.

Conclusion:

The results of the characterization methods strongly suggest that the aqueous leaf extract
of Murraya koenigii can be used as a reducing and stabilizing agent in the green synthesis of
FeNPs.
A Literature-Based Study of Tardive Dyskinesia- From Pathogenesis to Treatment
Authors: Kalita Banjit , Chakraborty Tapash , Ghose Shatabdi , Kalita Bhaskarjyoti
Published: September 2024

:

Tardive dyskinesia (TD) is induced by antipsychotic drugs that have dopamineantagonising
properties. It frequently causes physical and mental anguish in individuals, lowering
their quality of life. Recent research on the aetiology and pathogenesis of TD indicates that genetic
predisposition, treatment options, age, sex, and lifestyle factors are among the key risk factors contributing
to the development of TD. Various genetic polymorphisms along with severe oxidative
stress and other diseased conditions help to precipitate TD while on antipsychotic medications or
other dopamine receptor blockers. Individuals diagnosed with schizophrenia are at a higher likelihood
of developing TD. The current piece of literature aims to review the probable underlying
mechanisms of TD, explore its pathophysiology, address the diagnostic challenges, and present the
available treatment options. This comprehensive analysis draws from a range of published peerreviewed
publications, presenting the information in a clear and accessible manner.
Relasi mutualisme antara pemilik dan pekerja dalam usaha kecil dan menengah: studi kasus Denny Ice Cream Medan Johor
Authors: Pane Farhan Alpani , Sitanggang Ias Dita , Sihotang Primus
Published: September 2024

Hubungan pemilik usaha dan pekerja adalah saling membutuhkan, sehingga hubungan mereka seharusnya dipandang sebagai hubungan kemitraan. Kejelasan status relasi mereka  berdampak pada kelancaran usaha termasuk dalam usaha kecil menengah (UMKM) yang berkembang dalam masyarakat di Indonesia. Masing-masing pihak memiliki risiko selayaknya pekerja sektor formal, bahkan lebih besar khususnya risiko kehilangan pekerjaan. Urgensi untuk memperhatikan kesejahteraan pekerja dan melindungi dari kehilangan pekerjaan dan kecelakaan kerja merupakan suatu hal yang harus segera Studi pada usaha mikro Denny Ice Cream Medan Johor menunjukan kesadaran tentang hal ini. Manajemen usaha berbasis kekeluargaan, dimana pemilik usaha memperlakukan pekerjanya layaknya keluarga sendiri. Adanya jaminan sosial pekerja dan pemilik usaha meskipun sebatas pada BPJS kesehatan saja. Temuan ini mengaskan masih perlunya sosialisasi tentang perlindungan usaha bagi pemilik dan pekerja yang lebih baik dan pasti; sehingga mampu mengembangkan usahanya menjadi lebih produktif.
KOODJA, ondel-ondel dan eksistensi berkesenian di Jakarta
Authors: Sari Rosnida , Widiyaningsih Dewy Sri
Published: September 2024

Penelitian mendalami bagaimana KOODJA (Komunitas Ondel-Ondel DKI Jakarta) mengorganisir eksistensi seniman ondel-ondel dan berintegrasi dengan Dinas Kebudayaan Jakarta dalam upaya membangun kehadiran seni Betawi. Dengan metode kualitatif, penelitian mewawancarai pelaku baik dari KOODJA dan Dinas Kebudayaan Jakarta tentang upaya mempetahankan eksistensi berkesenian. Temuan penelitian mengungkap keberadaan solidaritas mekanik dalam pembentukan KOODJA oleh para penggiat seni ondel-ondel yang berbagi kesadaran kolektif dan identitas kelompok yang kuat. KOODJA juga mengembangkan solidaritas organik dengan Dinas Kebudayaan Jakarta untuk mengatur aktivitas para pengamen ondel-ondel. Kolaborasi ini penting untuk pelestarian, pengembangan, dan promosi seni ondel-ondel sebagai bagian penting dari identitas budaya Jakarta.
Understanding the Adoption of Mobile Wallets Amongst Rural Indian Women
Authors: Singh Mannat , Dahiya Rekha
Published: September 2024

Acknowledging the great paucity of studies concerning the mobile wallet adoption by the rural women in Indian context; this study intended to explore the mobile wallet (M-Wallet) adoption among Indian rural women along with understanding the factors affecting adoption, challenges and possibility of mobile wallet as a tool of women empowerment. This study adopted the embedded mix method design in which both qualitative and quantitative information were obtained concurrently, however the qualitative information was incorporated throughout the quantitative information. Using Census (2011) as frame of reference, data was collected from rural women of Delhi. Purposive and snowball sampling techniques were used for data collection. Data for qualitative phase was collected from 10 females, whereas for quantitative phase data was collected from 208 females. Qualitative data was analysed using thematic analysis whereas quantitative data was analysed with the help of SPSS employing one independent sample t-test and factor analysis. The study concluded that Paytm Google Pay and PhonePe were the most used mobile wallets amongst Indian rural women. Most common usage of mobile wallet by the Indian rural women included recharges and bill payments. Three factors namely the “perceived ease of use” “perceived usefulness” and “social norms” were identified as the facilitators or drivers. “Self-efficacy” was found essential for effectively using the mobile wallets; however rural Indian women considered themselves less confident possessing limited knowledge about the mobile wallets. “Perceived risk” was identified as a restraining factor impeding usage of mobile wallets. Lack of confidence, socio[1]cultural barriers, lack of financial resources and lack of awareness were highlighted as the major challenges faced by rural Indian women while using mobile wallets. Mobile wallets have the possibility to act as a tool of women empowerment by facilitating banking needs of the unbanked, fostering cooperation, self-dependence and promoting self-employment and business amongst the rural Indian women.
Investigation of classification of support vector machine on the estimation of the deciduous broad-leaved forests area in the north of Iran
Authors: Tabesh Mohammadreza , Hashemi Seyed Armin , Tabibian Sahar , Abbasipour Mohsen , Hosseini Maghsood
Published: September 2024

During the last decades, Caspian forests have been attacked by human interference. Easy access, abundance and diversity of valuable forest products have led to the increase in population density, the creation of new residential areas and the activity of deforestation. Revealing the changes is one of the basic methods in the management and evaluation of natural resources. The purpose of this study is to estimate the forest area using support vector machine classification model in Landsat 8 satellite images in Shafarood forests of Gilan province. The results of the image classification in the support vector machine method showed that the area of the forest in 2010 was equal to 12104.64 hectares, which has reached 9478.69 hectares in 2020, that is, its area has decreased by 2625.95 hectares due to changes in its use and its conversion to residential use and poor rangeland. With its growth in the years 2010 to 2020, residential use has changed from 1385.1 to 2542.35, that is, the area has increased by 1157.25 hectares. The changes in pasture use have also changed from 2707.74 to 4478.17 hectares, i.e. 1770.43. The reason for the increase in this could be that many parts of forest use have turned into poor rangeland. According to the Kappa coefficient and the overall accuracy obtained by the support vector machine classification in 2010 and 2020, for 2010, 95.76 and 91.75% and 99.72 and 99.62% were obtained in 2020. The results showed that the support vector machine method had a higher accuracy in the separation of uses.
Application of Spatial Analysis on Electronic Health Records to Characterize Patient Phenotypes: Systematic Review
Authors: Mollalo Abolfazl , Hamidi Bashir , Lenert Leslie A , Alekseyenko Alexander V
Published: September 2024

Background

Electronic health records (EHRs) commonly contain patient addresses that provide valuable data for geocoding and spatial analysis, enabling more comprehensive descriptions of individual patients for clinical purposes. Despite the widespread use of EHRs in clinical decision support and interventions, no systematic review has examined the extent to which spatial analysis is used to characterize patient phenotypes.

Objective

This study reviews advanced spatial analyses that used individual-level health data from EHRs within the United States to characterize patient phenotypes.

Methods

We systematically evaluated English-language, peer-reviewed studies from the PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar databases from inception to August 20, 2023, without imposing constraints on study design or specific health domains.

Results

A substantial proportion of studies (>85%) were limited to geocoding or basic mapping without implementing advanced spatial statistical analysis, leaving only 49 studies that met the eligibility criteria. These studies used diverse spatial methods, with a predominant focus on clustering techniques, while spatiotemporal analysis (frequentist and Bayesian) and modeling were less common. A noteworthy surge (n=42, 86%) in publications was observed after 2017. The publications investigated a variety of adult and pediatric clinical areas, including infectious disease, endocrinology, and cardiology, using phenotypes defined over a range of data domains such as demographics, diagnoses, and visits. The primary health outcomes investigated were asthma, hypertension, and diabetes. Notably, patient phenotypes involving genomics, imaging, and notes were limited.

Conclusions

This review underscores the growing interest in spatial analysis of EHR-derived data and highlights knowledge gaps in clinical health, phenotype domains, and spatial methodologies. We suggest that future research should focus on addressing these gaps and harnessing spatial analysis to enhance individual patient contexts and clinical decision support.
Determinants of an integrated management of childhood illness program implementation in Indonesia
Authors: Amalia Dwi Octa , Hadi Ella Nurlaella
Published: September 2024

Purpose: This study aims to identify the factors related to health system support that influence the implementation of Integrated Management of Childhood Illness (IMCI) in primary health care facilities in Indonesia, specifically in relation to leadership.
Methods: The research method used is a literature review. Database searches of  Garuda, Google Scholar, Proquest, Science Direct, Biomed, and Pubmed were performed from 2012 to 2022 using the keywords “manajemen terpadu balita sakit”, “IMCI Indonesia”.
Results: A total of 1,238 articles were screened for eligibility and five published articles met the inclusion criteria and objectives of this literature review. Based on five articles reviewed, nine variables associated with IMCI implementation were analyzed in this study, including leadership support, supervision, completeness of medicine and medical equipment, presence of consultation room, motivation, attitudes, knowledge, and completeness of filling out forms.
Conclusion: The support of the health system is a key challenge in implementing IMCI. Therefore, strengthening health system support is needed to optimize the implementation of IMCI. In addition, there is a need to strengthen leadership and provide regular supervision and feedback to ensure that IMCI implementation is in accordance with standards and to increase health worker motivation to improve their performance in providing health services.
Analysis of the implementation of the safety and health management system (SMK3) at The Sentani Community Health Center, Jayapura Regency
Authors: Korwa Henderjetac Carolina , Surono Agus , Jaladara Vena
Published: September 2024

Purpose: This research aims to analyze the implementation of the occupational safety and health management system at community health centers to determine the achievements of the implementation of occupational safety and health by looking at the indicator system from K3 policy, K3 planning, K3 implementation as well as K3 monitoring and evaluation at the Sentani Community Health Center, Jayapura Regency.
Methods: This type of research uses qualitative case study methods. The subjects of this research were health workers at the Sentani Community Health Center, Jayapura Regency, with a sample size of 10 respondents. The data collection technique is a triangulation technique involving observations, in-depth interviews, and documentation studies. The tool used is a questionnaire.
Results: The research shows that community health centers must fully implement an occupational safety and health management system. Based on the results of observations and interviews, it was found that the health center still needs to have a written K3 commitment and policy based on the SK—head of Pukesmas. There has been no significant risk research in determining K3 planning. The implementation of K3 at health centers has been implemented through health services, fire control and prevention, and the provision of K3 facilities and infrastructure. Monitoring and evaluation in implementing K3 still need to record and report on planning, implementation, or recording cases of work-related accidents (KAK) and work-related diseases (PAK) at health centers.
Conclusion: The safety and health management system must still be fully implemented. The need to review and analyze work risks for workers and the environment and become a benchmark in making K3 policy commitments at health centers in implementing occupational safety and health management systems.
Named Entity Recognition in Statistical Dataset Search Queries
Authors: Wildannissa Pinasti  , Lya Hulliyyatus Suadaa
Published: September 2024

Search engines must understand user queries to provide relevant search results. Search engines can enhance their understanding of user intent by employing named entity recognition (NER) to identify the entity in the query. Knowing the types of entities in the query can be the initial step in helping search engines better understand search intent. In this research, a dataset was constructed using search query history from the Statistics Indonesia (Badan Pusat Statistik, BPS) website, and NER in query modeling was employed to extract entities from search queries related to statistical datasets. The research stages included query data collection, query data preprocessing, query data labeling, NER in query modeling, and model evaluation. The conditional random field (CRF) model was employed for NER in query modeling with two scenarios: CRF with basic features and CRF with basic features plus part of speech (POS) features. The CRF model was used due to its well-known effectiveness in natural language processing (NLP), particularly for tasks like NER with sequence labeling. In this research, the basic CRF and the CRF model with POS feature achieved an F1-score of 0.9139 and 0.9110, respectively. A case study on a Linked Open Data (LOD) statistical dataset indicated that searches with synonym query expansion on entities from NER in query produced better search results than regular searches without query expansion. The model's performance incorporating additional POS tagging features did not result in a significant improvement. Therefore, it is recommended that future research will elaborate on deep learning.
GSA dengan Skrining Faktor untuk Evaluasi Kinerja Relai Proteksi Saluran
Authors: Nanang Rohadi  , Bambang Mukti Wibawa  , Nendi Suhendi
Published: September 2024

Makalah ini menyajikan analisis kepekaan global (global sensitivity analysis, GSA) dengan skrining faktor untuk pengujian secara efisien terhadap model algoritma relai jarak konvensional ketika digunakan sebagai perangkat proteksi saluran transmisi dengan kompensator seri. Sejumlah parameter ketidakpastian (faktor) sistem dapat memengaruhi kinerja fungsional model algoritma pengukuran impedansi gangguan dari perangkat elektronik cerdas (intelligent electronic devices), yaitu relai jarak tipe SEL-421. Pengujian kepekaan global dimaksudkan untuk menentukan tingkat kekuatan pengaruh dari individu maupun interaksi antarfaktor terhadap keluaran algoritma pengukuran impedansi gangguan. GSA melalui analisis varians menggunakan kuasi-Monte Carlo dimaksudkan untuk melakukan komputasi terhadap kesalahan hasil pengukuran impedansi gangguan. Metode Morris sebagai langkah awal digunakan sebagai penyaringan terhadap faktor yang tidak terlalu dominan memengaruhi kinerja relai, sehingga mengurangi beban komputasi pada GSA. Sejumlah simulasi gangguan pada saluran transmisi dengan kompensator seri dan sejumlah faktor dimodelkan dengan DIgSILENT PowerFactory. Simulasi gangguan secara otomatis sebelum dan sesudah kompensator dikembangkan menggunakan DIgSILENT. Kepekaan keluaran algoritma relai diuji untuk setiap simulasi berdasarkan sinyal tegangan dan arus gangguan yang terbaca dan juga nilai dari sampel faktor pada ruang faktor melalui kedua metode, yaitu Morris dan Sobol. Untuk sejumlah vektor sampel, varians dari model keluaran algoritma yang dipengaruhi oleh sejumlah faktor dihitung melalui perangkat lunak SIMLAB. Resistansi kegagalan adalah faktor yang dominan memengaruhi kinerja algoritma untuk gangguan sebelum dan sesudah kompensator. Indeks kepekaan relai terhadap resistansi kegagalan sangat dominan, yaitu lebih dari 0,9 dan 0,7, masing-masing untuk gangguan sebelum dan sesudah kompensator. Teknik ini berhasil digunakan dalam pengujian algoritma relai jarak SEL-421.
INVESTIGATING THE ROLE OF NANOPARTICLE-BASED CURCUMIN IMPLANTS IN PREVENTION OF POST-LAPAROTOMY PERITONEAL ADHESION: AN IN VIVO STUDY
Authors: KABOLI MOHAMMAD AMIN , ALTEMEMY DHIYA , JAVDANI MOOSA , KHOEI HOSSEIN AMINI , MEHREGANZADEH PARISA , DRISS FATEMEH , KARIMI MEHRDAD , KHOSRAVIAN PEGAH
Published: September 2024

Objective: The objective of this research is to develop a controlled-release drug delivery system for relieving peritoneal adhesion. The system is designed to utilize a polymer hydrogel incorporating Curcumin (cur) loaded Mesoporous Silica Nanoparticles (Msn). Its objective is to improve the properties of curcumin and reduce peritoneal adhesion after laparoscopic surgery.
Methods: The rats in each group underwent intra-abdominal adhesion modeling surgery and received the following implants: implants containing Msn loaded with cur (imp/Msn@cur), Implants Containing Cur (imp/cur), implants containing Msn without cur (imp/Msn), Implants without Msn and cur (imp) and group only modeled (contrl). After 14 d, the surgical site was reopened and the specimens were evaluated by gross processing and histology staining for adhesion band formation, fibrosis, and inflammation. Data were analyzed by SPSS v.22 using Fisher's exact test, one-way ANOVA, and Tukey's test and P˂0.05 was considered statistically significant.
Results: The number of vascularized or non-vascularized adhesion bands was evaluated According to the results, the number of vascular bands in the control group was only significantly higher than the other groups (P<0.001). Also, the mean number of vascular adhesion bands in the imp group was significantly higher than the other intervention groups (P<0.001). All studied rats in the contrl group had adhesions and the severity of adhesions in this group was higher than the others. Also, in the imp/Msn@cur group, the severity of adhesion was the lowest than the other groups.
Conclusion: The research findings indicated that utilizing implants with cur-loaded Msn resulted in improved peritoneal adhesion and reduced collagen bandages following laparotomy.
ZAP-AIRTMMICRONIZER: IMPACT ON NEBULIZED SALBUTAMOL SULPHATE AND IPRATROPIUM BROMIDE PARTICLE SIZE
Authors: ZAMERY MUHAMMAD IZZUDDIN , SAHUDIN SHARIZA , RAHMAN SHAHARIZUAN ABDUL , KOW ALBERT
Published: September 2024

Objective: This study aimed to investigate the effect of the patented Zap-Air™ Micronizer on the particle size reduction of salbutamol sulphate (Ventolin), ipratropium bromide (Atrovent), and their combination (Combivent) nebulizing solutions.
Methods: The study used an Omron Compressor Nebulizer NE-C28 and compressed oxygen at flow rates of 3L and 6L per minute. Particle size analysis was conducted using Malvern Spraytec Laser Diffraction System to measure DV4 (4% of particles in the sample), DV50 (50% of particles in the sample), DV90 (90% of particles in the sample). Drug deposition analysis was performed using the Next Generation Pharmaceutical Impactor (NGI) with High-Performance Liquid Chromatography (HPLC) to analyze the content at each stage.
Results: The Zap-Air™ Micronizer effectively reduced the particle size of salbutamol sulphate and ipratropium bromide to less than 2 μm. Both Unit 1 and Unit 2 micronizers showed significant particle size reduction, with the average size of 50% of particles (DV50) being below 1 μm. Drug release intensity was significantly reduced when using the micronizers compared to the nebulizer alone.
Conclusion: The Zap-Air™ Micronizer has the potential to enhance drug delivery and therapeutic effects in the treatment of Asthma and Chronic Obstructive Pulmonary Disease (COPD) by improving the deposition of salbutamol sulphate and ipratropium bromide into the smaller airways of the lungs.
METALLOPROTEIN PARAMETERS IN MOLECULAR DYNAMICS SIMULATION FOR AMBER, CHARMM, GROMACS, AND NAMD: A SYSTEMATIC REVIEW
Authors: PUTRA PURNAWAN PONTANA , FITRIA NAJMIATUL , ASNAWI AIYI , DJAMAAN AKMAL
Published: September 2024

Objective: The selection of appropriate metal parameters for molecular dynamics simulations is a significant challenge. Therefore, this review aims to provide in-depth insights valuable for the optimization of parameter selection in the context of chemical simulations.
Methods: A total of 550 scientific articles were collected from pubmed and science direct databases from 2009 to 2024, resulting in the inclusion of 60 full studies for review. The selection process of preferred reporting items for systematic reviews and meta-analyses (PRISMA) was utilized, enabling the conduction of an initial screening of articles by use of the Rayyan web-based application.
Results: This study found that the modeling and parameterization of metal proteins were categorized into bonded and non-bonded models. The Bonded Model incorporates MCPB, a Python-based software that facilitates parameter construction for over 80 metal ions and force fields in molecular dynamics simulations. The non-bonded model evaluates metals in proteins, such as zinc, nickel, magnesium, cobalt, iron, and cadmium by using AMBER force field and the Seminario method. The 12-6 lennard-Jones (LJ) non-bonded model is suitable for divalent, trivalent, and tetravalent metals, with Zinc parameters being compared for accuracy. Additionally, the force fields suitable for modeling unbound metal proteins include AMBER FF19SB, FF14SB, ff9X, CHARMM36, CHARMM22, CHARMM27, and CHARMM-Metal.
Conclusion: This study found that the modeling and parameterization of metal proteins were categorized into bonded and non-bonded models. molecular dynamics (MD) simulations can be conducted using various methods, such as classical molecular dynamics, umbrella sampling, quantum mechanics-discrete molecular dynamics (QM/DMD), stochastic boundary molecular dynamics (SBMD), steered molecular dynamics (SMD), gaussian accelerated molecular dynamics (GaMD) and random acceleration molecular dynamics (RAMD).
DESIGNING, DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING HBS SYSTEM OF METFORMIN: IN VITRO IN VIVO STUDIES
Authors: SAMANTA RADHESHYAM , TIWARI GAURAV , GUPTA NAVEEN , RAJPUT DHARMENDRA SINGH
Published: September 2024

Objective: The main objective of this study is to formulate, characterized and evaluate the Medium Molecular Mass Chitosan (MMMCH) – Xanthan Gum (XG) based polymeric carrier mediate of non-effervescent floating hydrodynamically Balanced System (HBS) capsule of metformin for developed stomach specific sustain drug delivery over a prolong periods of time.
Methods: Different capsules of metformin were formulated by physical blending of metformin with polymeric mixture to encapsulate in 000 a single unit hard gelatine capsule, than evaluate the different parameters like micromeritics properties, weight uniformity, drug content uniformity, in vitro drug release with their kinetics model, DSC and FTIR study, in vitro in vivo floating characteristic.
Results: After evaluating the characteristic properties, it was clearly indicated that excellent value ranges, coefficient of weight variation in between 1.39-2.06%, content uniformity of drug in between 98.23-100.05%, in vitro drug release in between 60–80 % after 12h that can follow Korsmeyer-Peppas model to release the drug no-fiction diffusion method. FTIR and DSC study exhibit no much more incompatibility between drug and polymer and formation of electrolyte complex help to sustaining release over a prolong periods of time. In vitro and in vivo floatation study, it was clearly indicated that all formulation (especially MC4) floated in gastric content more than 12h without any floating lag time and excellent in vivo buoyancy by the help of x ray images of animal model by replacing the drug with barium sulphate.
Conclusion: So this type of formulation showing great gastroretentive floating drug delivery system in future with another drugs for a prolong periods of time.
Comparative analysis of Chlorophyll concentration in different species of leafy vegetables cultivated in soil and hydroponic system
Authors: R Ghritlahre , L. Prabhas , A. Megha
Published: September 2024

Leafy vegetables are an important vegetable crop that grows easily under controlled conditions, such as in hydroponic. A plant's leaf colours can be used to indicate stress levels due to its adaptability to environmental changes. In this study, the samples were cultivated in the backyard of the Life Science department in Pandit Ravishankar Shukla University, Raipur, Chhattisgarh during January to April 2024. In this study, fresh mature leaves of soil-cultivated plants and hydroponically cultivated plants were taken for chlorophyll estimation. The sample was tested using an acetone solution (80%) and the information from the spectrum was calculated using the Arnon’s method. The levels of Chl. a and Chl. b in soil-grown and hydroponically grown plants have been found to differ. Hydroponic cultivated plants show a high amount of total chlorophyll content as compared to soil-based plants and the reason behind the high level of chlorophyll content ina hydroponic system is controlled environmental conditions that mean precise control over light, temperature, and nutrient availability and are highly specific from species to species whereas, in a soil-based system, it is difficult to maintain such condition.
5 Fragen – 5 Antworten: 30 Jahre Fachhochschulen in Österreich
Authors:   FHK - Österreichische Fachhochschul-Konferenz, Koleznik Kurt , Esca-Scheuringer Heidi
Published: September 2024

Welche politischen Überlegungen haben zur Gründung der Fachhochschulen im Jahr 1993 geführt? Welche Erwartungen wurden damals bei ihrer Gründung und werden heute an sie gestellt? Was sind ihre Alleinstellungsmerkmale und warum sind sie für den Wissenschaftsbetrieb innerhalb kurzer Zeit zum unverzichtbaren Bestandteil geworden? Auf diese und weitere Fragen bietet der vorliegende Beitrag Antworten.
Research organisation and research strategies at Universities of Applied Sciences (UAS) in the tension triangle between politics, researchers, and internal decision makers: a case study example of the IMC Krems in Austria
Authors:   IMC Krems, Berger-Grabner Doris , Handhofer Doris , Ihden Tanja , Kuhnle-Schadn Alexandra
Published: September 2024

This study examines the circumstances and unique features of research activity at Austrian Universities of Applied Sciences (UAS), highlighting the various demands and interests of various stakeholders. Utilizing a case study approach based on an extensive literature review, data was gathered regarding the preferences and expectations of various UAS stakeholders, both present and future, in order to identify any gaps or conflicting needs that need to be taken into account in an all-encompassing research strategy. Guideline-based interviews with experts, the management board and researchers at the IMC Krems were conducted. The findings demonstrate how competitive and dynamic the UAS sector is, with a focus on applied research and teaching activities. UAS are characterised by a relatively broad range of research topics with moderate relative specialisation, application orientation and close collaboration with local stakeholders. The majority of research funding at UAS comes from third-party funds or commissioned research, because the institution lacks basic research financing. Main opportunities for UAS are seen in dissertation rights for this sector and basic funding from the federal government to have more open-topic research. The findings of this study should encourage UAS to critically evaluate their research organisation and align it with their core mission: teaching and applied research.
Die strategische Neuausrichtung der Forschung an der FH Salzburg im Rahmen eines gesamthochschulischen Organisationsentwicklungsprozesses
Authors:   FH Salzburg, Engel Dominik , Huber Stefan , Leeb Markus , Leitner Michael Christian , Rieß-Just Cornelia , Oostingh Gertie Janneke , Warta Katharina
Published: September 2024

Die Fachhochschule Salzburg (FHS) hat sich seit 2020 sowohl in der Governance als auch in der Organisationsstruktur neu aufgestellt. Den nunmehr sechs Departments stehen Forschungsschwerpunkte gegenüber, die wiederum in unterschiedlichen Intensitäten in drei Wirksamkeitsfeldern tätig sind. Im Jahr 2023 wurde das Land Salzburg neben der Arbeiterkammer Salzburg (AKS) und der Wirtschaftskammer Salzburg (WKS) dritter Eigentümer. Mit diesem Einstieg sollte ein Forschungsfonds eingerichtet werden, um die neu strukturierte Forschung an der FHS zu unterstützen. Im vorliegenden Beitrag werden die strategischen Prozesse und partizipativen Formate beleuchtet, die sowohl die FHS-weite Organisationsentwicklung als auch den Prozess der Vergabe und des Monitorings der Forschungsmittel betreffen, sowie die Überlegungen, die zu bestimmten Entscheidungen geführt haben. Alte und neue Struktur werden einander gegenübergestellt und die Mechanismen der Zielüberprüfung, Evaluierung und Governance erläutert. Danach wird auf Herausforderungen in der Umsetzung und Limitierungen der neuen Ausrichtung eingegangen. In diesem Zusammenhang werden einige grundlegende Überlegungen zur Finanzierung von Forschung an Fachhochschulen angestellt, mit speziellem Augenmerk auf Prinzipien bei der strategischen finanziellen Unterstützung durch Eigenmittel bzw. Mittel der FH-Trägereinrichtungen.
La inteligencia emocional: una ruta para la igualdad de género
Authors: Vázquez Valencia Claudia Yenmi , Campos Uscanga Yolanda
Published: September 2024

La inteligencia emocional es el conjunto de capacidades sociales y emocionales que nos permiten enfrentar la vida de forma satisfactoria. Sin embargo, por muchos años, la sociedad ha fomentado estas capacidades de forma distinta en mujeres y hombres, contribuyendo a la desigualdad de oportunidades en diferentes ámbitos. En tiempos de lucha por derechos justos, es necesario generar condiciones para tener acceso a las mismas oportunidades. Por este motivo, el objetivo de este artículo es dar claridad al concepto de inteligencia emocional para entender su importancia, reflexionar sobre las diferencias entre mujeres y hombres, y, finalmente, cambiar ideas, discursos o acciones, lo que permitirá una transformación social encaminada a reducir la brecha de género.
¿Qué hay detrás del cáncer? Una mirada desde su origen hasta su tratamiento
Authors: Colín Val Zaira
Published: September 2024

El cáncer es una enfermedad que se produce cuando algunas células del cuerpo comienzan a dividirse sin control, hasta formar masas llamadas tumores. Actualmente se sabe que el cáncer ha existido en la tierra desde antes de que aparecieran los humanos y puede ser ocasionado por diferentes factores, ya sean genéticos, ambientales o ambos. Dependiendo del lugar donde el tumor se localice, hay diferentes tipos de cáncer. Saber más sobre esta enfermedad nos ayudará a cuidarnos para prevenirla o detectarla a tiempo y obtener el tratamiento adecuado. Únete a nosotros en esta fascinante y reveladora aventura sobre el cáncer, explorando su historia y desmintiendo algunos de los mitos más comunes acerca de esta enfermedad.
Los microplásticos como vehículo del cadmio: ¿Una interacción peligrosa para los organismos acuáticos?
Authors: Bonilla Aguirre Laura Leticia , Valencia Castañeda Gladys , Escobar Sánchez Ofelia
Published: September 2024

El uso indiscriminado de plásticos ha llevado a su presencia como desecho en prácticamente todo el planeta. Este material se fragmenta en pequeñas piezas, conocidas como microplásticos (MPs), que se dispersan fácilmente. En los ambientes acuáticos, los MPs están ampliamente distribuidos y pueden interactuar con otros contaminantes, como el cadmio (Cd), un metal tóxico incluso a bajas concentraciones. La adsorción de Cd en MPs facilita su ingreso en los organismos que los ingieren accidentalmente, lo que podría amplificar su toxicidad debido a un efecto sinérgico. Aunque esta interacción tiene el potencial de causar mayores daños en la salud de los organismos, ha sido poco estudiada. Este trabajo tiene como objetivo realizar una revisión sintética de investigaciones recientes sobre la interacción y los efectos del Cd y los MPs en los organismos acuáticos.
The Path Forward: Insights of Urban Agriculture and Sustainable Development From Bibliometric Analysis and Systematic Literature Review
Authors: B Sreejith
Published: September 2024

In a world that is quickly urbanising, urban agriculture is viewed as an essential component of environmentally responsible urban development. Since this is the case, it is necessary to have a comprehensive framework for evaluating the performance of urban agriculture in terms of urban sustainability. In order to provide an explanation for the publication trend, prominent authors and publications, and significant study areas in the subject of urban agriculture and sustainable development, this work makes use of bibliometric analysis. The bibliometric study provides policymakers with significant insights that can be used to build evidence-based policies that support the growth, development, and sustainability of urban agriculture. Current research trends in the field of urban agriculture and sustainable development are elucidated by our comprehensive review of the relevant literature. As an additional benefit, the study provides researchers
Efficient Classical Shadow Tomography through Many-body Localization Dynamics
Authors: Zhou Tian-Gang , Zhang Pengfei
Published: September 2024

Classical shadow tomography serves as a potent tool for extracting numerous properties from quantum many-body systems with minimal measurements. Nevertheless, prevailing methods yielding optimal performance for few-body operators necessitate the application of random two-qubit gates, a task that can prove challenging on specific quantum simulators such as ultracold atomic gases. In this work, we introduce an alternative approach founded on the dynamics of many-body localization, a phenomenon extensively demonstrated in optical lattices. Through an exploration of the shadow norm – both analytically, employing a phenomenological model, and numerically, utilizing the TEBD algorithm – we demonstrate that our scheme achieves remarkable efficiency comparable to shallow circuits or measurement-induced criticality, resulting in a significant improvement in the exponential exponent compared to the previous classical shadow protocol. Our findings are corroborated through direct numerical simulations encompassing the entire sampling and reconstruction processes. Consequently, our results present a compelling methodology for analyzing the output states of quantum simulators.
Analisis Penerapan Hygiene dan Sanitasi Dapur
Authors: Putra I Wayan Rian Prasatya , Semara I Made Trisna
Published: September 2024

Tujuan dilakukan penelitian ini untuk menganalisis tentang upaya menjaga dan penerapan hygiene dan sanitasi dapur di Restaurant XXX. Informan peneliti ini adalah para karyawan dapur Restaurant XXX. Dengan penelitian ini akan diketahui hal-hal yang perlu dipertahankan sekaligus hal-hal yang perlu ditingkatkan Metode pengumpulan data menggunakan metode wawancara, observasi dan dokumentasi. Teknik analisis dalam penelitian ini menggunakan teknik analisis deskriptif kualitatif dengan melakukan observasi yang beracuan dengan SOP (Standard Operating Procedure) hygiene dan sanitasi yang telah ditetapkan. Masalah yang dihadapi dalam menerapkan penerapan hygiene dan sanitasi area dapur, penerapan hygiene dan sanitasi peralatan dapur serta penerapan personal hygiene adalah kurangnya kesadaran diri pada saat melakukan pekerjaan, adanya karyawan yang belum sepenuhnya mengetahui bagaimana cara persiapan diri dan pembersihan pada area dapur dengan benar. Sebaiknya dilakukan refreshment kepada karyawan dapur agar semuanya tahu dan ingat bagaimana SOP yang sebenarnya harus di terapkan dan agar tidak terjadinya perbedaan penerapan dari persiapan diri karyawan serta pembersihan pada area dapur sesuai dengan SOP yang telah ditetapkan.
 
The purpose of this studiy was to analyze the efforts to maintain and apply kitchen hygiene and sanitation at Restaurant XXX. The research informants were Restaurant XXX kitchen employees. This research will identify things that need to be maintained as well as things that need to be improved. Data collection methods use interviews, observation and documentation. The analysis technique in this study used a qualitative descriptive analysis technique by making observations with reference to the established standard operating procedure (SOP) for hygiene and sanitation. The problem encountered in implementing the implementation of hygiene and sanitation in the kitchen area, the application of hygiene and sanitation of kitchen equipment and the application of personal hygiene is a lack of self-awareness when doing work, there are employees who do not fully know how to properly prepare and clean the kitchen area. It is better to do refreshments for kitchen employees so that everyone knows and remembers how the actual SOP should be applied and so that there are no differences in the implementation of employee self-preparation and cleaning in the kitchen area according to the SOP that has been set.
Implementasi Konsep Tri Hita Karana pada Aspek Palemahan
Authors: Sudewi Ni Luh Made Cipta , Susanti Luh Eka
Published: September 2024

Masalah lingkungan merupakan masalah global yang juga menjadi perhatian. Penelitian ini bertujuan untuk menegtahui bagaimana pengimplementasian konsep Tri Hita Karana pada aspek Palemahan serta bertujuan untuk mengetahui apa saja kendala yang dialami pihak hotel dalam mengelola sampah hasil industrinya. Penelitian ini dilakukan di Kastara Resort and Spa yaitu salah satu hotel berbintang 4 di Ubud. Metode penelitian yang digunakan adalah metode pendekatan kuantitatif dengan tipe deskriptip. Pengumpulan data menggunakan teknik observasi, kuesioner, wawancara serta dokumentasi. Populasi dalam penelitian ini adalah seluruh karyawan Kastara Resort and Spa. Sampel dari penelitian ini adalah 30 karyawan dari Human Resource Department, Housekeeping Department, Food and Beverage Service Department dan Food and Beverage Product Department. Hasil penelitian menunjukan bahwa aspek Palemahan di Kastara Resort and Spa belum diimplementasikan dengan maksimal. Kendala yang dihadapi pihak hotel dalam mengola sampah hasil industrinya yaitu belum disediakannya tempat sampah yang cukup banyak untuk melakukan pemisahan sampah berdasarkan jeisnya, kendala tempat karena kecilnya area operasional, pengangkutan sampah yang berkerjasama dengan dinas Desa Keliki tidak dilakukan setiap hari serta belum mempunyai tenaka kerja yang mempunyai keahlian khusus dalam mengelola sampah hasil industrinya.
 
Environmental problems are global problems that are also a concern. This research aims to find out how the Tri Hita Karana concept is implemented in the Palemahan aspect and to find out what are the problem experienced by the hotel in managing its industrial waste. This research was conducted at Kastara Resort and Spa, a 4-star hotel in Ubud. The research method used is a quantitative approach with a descriptive type. Data collection using observation techniques, questionnaires, interviews and documentation. The population in this research were all Kastara Resort and Spa employees. The sample of this study were 30 employees from the Human Resource Department, Housekeeping Department, Food and Beverage Service Department and Food and Beverage Product Department. The results of the study show that the Palemahan aspect at Kastara Resort and Spa has not been implemented optimally. The problem faced by the hotel in processing industrial waste are that there are not enough trash bins available to separate waste based on its type, space constraints due to the small operational area, waste transportation in collaboration with the Keliki Village service is not carried out every day and does not have a qualified workforce. has special expertise in managing industrial waste.
Persepsi Wisatawan Generasi Z Terhadap Objek Wisata Pasar Ekstrem Tomohon
Authors: Purba George Michael Carona , Suwintari I Gusti Ayu Eka , Semara I Made Trisna
Published: September 2024

Pasar Ekstreme Tomohon merupakan salah satu objek wisata budaya yang ada di Sulawesi Utara. Keberadaan objek wisata ini kerap memicu kontroversi dan berbagai macam perspektif dari berbagai macam kalangan usia, termasuk Generasi Z.  Generasi Z merupakan orang yang lahir pada kurun tahun 1995-2010, serta merupakan penduduk terbanyak di Indonesia. Penelitian ini bertujuan untuk mengetahui persepsi wisatawan generasi Z terhadap objek wisata pasar ekstreme tomohon di Sulawesi Utara. Metode yang digunakan dalam penelitian ini adalah metode deskripftif kuantitatif dimana data diperoleh melalui kuesioner dengan tujuh indikator, diantaranya: persepsi internal, persepsi eksternal, atraksi, amenitas, aksesibilitas, dan ancillary. Hasil penelitian menunjukkan wisatawan Generasi Z memberikan tanggapan dengan akumulasi rata rata nilai 3,04 dari 5, dengan kategori ragu-ragu. Data tersebut menunjukan bahwa persepsi serta komponen pariwisata yang dimiliki Pasar Ekstreme Tomohon sudah baik, namun adapun beberapa aspek yang perlu ditingkatkan. Dalam pengembangan kedepanya perlu disarankan adanya peningkatan terkait fasilitas umum di objek wisata pasar ekstrem tomohon khususnya toilet, melaksanakan kegiatan bersih bersih setelah jam operasional, serta untuk pemerintah kedepan hendaknya mulai melakukan kolaborasi dengan luar negeri untuk lebih memperkenalkan uniknya budaya yang dimiliki oleh masyarakat lokal sulawesi utara, khususnya objek wisata Pasar Ekstreme Tomohon.
 
Tomohon Extreme Market is one of the cultural tourist attractions in North Sulawesi. The existence of this tourist attraction often triggers controversy and various perspectives from various age groups, including Generation Z. Generation Z are people born in the period 1995-2010, and are the largest population in Indonesia. This research aims to determine the perceptions of generation Z tourists towards the Tomohon extreme market tourist attraction in North Sulawesi. The method used in this research is a quantitative descriptive method where data is obtained through a questionnaire with seven indicators, including: internal perception, external perception, attractions, amenities, accessibility and ancillary. The research results show that Generation Z tourists responded with an average accumulated score of 3.04 out of 5, in the doubtful category. This data shows that the perception and tourism components of the Tomohon Extreme Market are good, but there are several aspects that need to be improved. In future development, it is recommended that there be improvements related to public facilities at the Tomohon extreme market tourist attraction, especially toilets, carrying out cleaning activities after operational hours, and for the future the government should start collaborating with foreign countries to further introduce the unique culture of the local people of North Sulawesi, especially the Tomohon Extreme Market tourist attraction.