bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Approach to Construct Fuzzy Systems Based on Fireworks Optimization Algorithm
Authors: Zhu Xiaodong , Liu Chong , Guo Yamo
Published: July 2015

To find an optimal balance between accuracy and model transparency in fuzzy systems modeling, a novel approach based on the non-dominated sorting fireworks optimization algorithm (NSFOA) is proposed in this paper. The FOA is a new swarm intelligence algorithm mimicking the explosion of fireworks, which could be used to tune the parameters and optimize the structure of fuzzy systems with high effectiveness and correctness. At each iteration of the NSFOA algorithm, all individuals are sorted based on fast non-dominated sorting and crowding-distance evaluation, and the multiobjective fitness functions consider the aspects of both interpretability and accuracy contemporaneously. Subsequently, the individuals with better transparency and accuracy are selected for the next generation. The proposed NSFOA algorithm is applied to the second-order non-linear system and the Iris benchmark problem, and the experimental results demonstrate that our method leads to comprehensible fuzzy models with remarkable accuracy.
Corpus callosum and epilepsies
Authors: Bauer Gerhard , Płonka-Półtorak Elżbieta , Bauer Richard , Unterberger Iris , Kuchukhidze Giorgi
Published: July 2015

Introduction.Corpus callosum (CC) is the largest forebrain commissure. Structural anomalies and accompanying clinical symptoms are not in the focus of neurologists, epileptologists or neurosurgeons.

Aim and method.Anatomy, embryological development, normal functions, structural abnormalities, additional malformations, clinical symptoms and seizure disorders with CC anomalies are reviewed from the literature.

Review.The detection of callosal anomalies increased rapidly with widespread use of brain imaging methods. Agenesis or dysgenesis of corpus callosum (AgCC) might be considered an accidental finding. Epileptic seizures occur in up to 89% of patients with AgCC. The causal relationship correctly is questioned. However, additional causative malformations of midline and/or telencephalic structures can be demonstrated in most seizure patients. The interruption of bilateral spread of seizure activities acts as the concept for callosotomy as epilepsy surgery. Indications are drug-resistant generalized, diffuse, or multifocal epilepsies. A resectable seizure onset zone should be excluded. Most treated patients are diagnosed as Lennox-Gastaut or Lennox-like syndrome.

Conclusions.In cases with callosal abnormalities and clinical symptoms additional malformations are frequently observed, especially with seizure disorders. Callosotomy is the most effective option against drop attacks. The method probably is underused. After callosotomy a circumscript seizure focus might be unveiled and a second step of resective epilepsy surgery can be successful.
Successful treatment with adjunctive lacosamide in a patient with long term “drug resistant” focal epilepsy
Authors: Fröscher Walter , Rauber Alois
Published: July 2015

Introduction.A significant number of patients suffering from epilepsy prove to be resistant to antiepileptic drugs (AEDs). Recent studies, however, suggest that 10–20% of seemingly drug resistant patients may still become seizure-free under the influence of subsequent dosage modifications.

Case report.We report on a young man with cryptogenic focal epilepsy. He had his first seizure at the age of fifteen. His seizure frequency was decreased during the following 11 years. However, seizure-freedom was never achieved even though he was treated with twelve to fourteen different AEDs during this time. Intensive presurgical evaluations did not allow identification of a surgically remediable focus. Adjunctive treatment with lacosamide 400 mg/day was not successful. However, the patient became seizure-free immediately after an increase of the lacosamide dose up to 500 mg/day. The patient is now seizure-free for more than two years based on a combination of 500 mg lacosamide and 350 mg lamotrigine, followed by 550 mg and 250 mg, respectively.

Discussion and conclusion.This case report highlights that there is always a chance that modifying the medication can result in a drug-resistant epilepsy patient experiencing a significant reduction of seizures and becoming seizure-free. The decisive step in this example was the off-label prescription of a high dose of lacosamide which the patient tolerated well.
Ictal Forced Repetitive Swearing in Frontal Lobe Epilepsy: Case report and review of the literature
Authors: Dolatshahi Marjan , Yankovsky Alexei
Published: July 2015

Introduction.Dominant presentation of ictal forced repetitive swearing has been rarely addressed and could be misdiagnosed.

Case report.We report a 45-year-old man with a long history of right frontal lobe epilepsy (FLE) who developed forced repetitive swearing during hypermotor seizures. His seizures were refractory to different antiepileptic drugs (AEDs). Scalp video-EEG telemetry suggested a right frontal epileptic focus. Magnetic resonance imaging (MRI) suggested focal cortical dysplasia (FCD) in the right mesial frontal lobe. Intracranial implantation with video-EEG recordings confirmed seizures originating from the MRI lesion. Patient underwent right frontal lobe resection followed by seizure freedom in the last five years on a single AED. Neuropathology confirmed FCD type IIB.

Discussion.The following aspects of the case are discussed: FLE and ictal vocalization, swearing, FLE and aggression. We emphasize the differences among ictal vocalisation, verbal automatism and ictal speech. We propose that ictal swearing might fit a verbal automatism definition.

Conclusion.Ictal forced repetitive swearing can be a manifestation of hypermotor seizures in FLE and should not be misdiagnosed.
20th Annual Meeting of the German-Austrian-Swiss Epilepsy Working Group
Authors: Stefan Hermann
Published: July 2015

The stated purpose of the meeting was to summarize „current, new and proven approaches in diagnostics and epilepsy therapy”, to define optimal clinical practice and scientific research areas, highlight advances in clinical and basic science and to identify future approaches or directions in epilepsy treatment.
Improving the tribological behavior of internal combustion engines via the addition of nanoparticles to engine oils
Authors: Ali Mohamed Kamal Ahmed , Xianjun Hou
Published: July 2015

The friction between two sliding surfaces is probably one of the oldest problems in mechanics. Frictional losses in any I.C. engine vary between 17% and 19% of the total indicated horse power. The performance of internal combustion engines in terms of frictional power loss, fuel consumption, oil consumption, and harmful exhaust emissions is closely related to the friction force and wear between moving parts of the engine such as piston assembly, valve train, and bearings. To solve this problem, most modern research in the area of Nanotribology (Nanolubricants) aims to improve surface properties, reduce frictional power losses, increase engine efficiency, and reduce consumed fuel and cost of maintenance. Nanolubricants contain different nanoparticles such as Cu, CuO, TiO
Diffractive wavefront correction of remote sensing systems based on pulsed laser diodes
Authors: Wojtanowski J. , Traczyk M. , Mierczyk Z. , Zygmunt M. , Przybyszewski B.
Published: July 2015

A variety of optoelectronic devices (rangefinders, velocity meters, terrestrial scanners, lidars, free space optics communication systems and others) based on semiconductor laser technology feature low−quality and highly asymmetric beams. It results from optical characteristics of the applied high−peak−power pulsed laser sources, which in most cases are composed of several laser chips, each containing one or a few active lasers. Such sources cannot be considered as coherent, so the resultant beam is formed by the superposition of many optically uncorrelated sub-sources. Far−field distribution of laser spots in such devices corresponds to the shape of laser emitting area, which instead of desired symmetry shows layout composed of one or several discrete lines or rectangles. In some applications, especially if small targets are concerned, it may be crucial to provide more symmetrical and uniform laser beam cross−section. In the paper, the novel strategy of such correction, combining coherent and incoherent approaches, is presented. All aspects of technological implementations are discussed covering general theoretical treatment of the problem, diffractive optical element (DOE) design in the form of computer generated hologram (CGH), its fabrication and testing in case of selected laser module beam correction.
Glucosyloxymethylfurfural (GMF): a creative renewable scaffold towards bioinspired architectures
Authors: Tan Jia-Neng , Ahmar Mohammed , Queneau Yves
Published: July 2015

Glucosyloxymethylfurfural (GMF) is the glucosylated analogue of hydroxymethylfurfural (HMF), and is obtained in one step from the very available disaccharide isomaltulose. This account gives an overview on the preparation and the uses of GMF towards architectures containing a carbohydrate moiety and shows that rather elaborated targets can be synthesized from GMF in very short sequences. A special focus is made on carbon–carbon formation on the aldehyde group leading to new biobased acrylic derivatives by the Baylis–Hillman reaction.
Evaluation of the quality of life of women treated due to breast cancer using amputation or breast conserving surgery in the early postoperative period
Authors: Nowicki Andrzej , Licznerska Bernardeta , Rhone Piotr
Published: July 2015

Selection of the treatment method in breast cancer patients and its consequences may affect their quality of life through somatic, psychical, and social factors.

The aim of the study was early evaluation of the quality of life of women after mastectomy vs. breast conserving surgery.

Material and methods. The study included 100 women aged 31 to 79 years (mean: 57) who underwent surgery due to breast cancer (amputation: 52; breast conserving surgery: 48 women) at the Cancer Centre in Bydgoszcz in 2014. The QLQ C-30 and QLQ BR-23 questionnaires were used to evaluate the quality of life of the patients 3 months after surgery.

Results. In the Global Health Status/QoL domain, the mean score for women after amputation and breast conserving surgery was 49 and 53, respectively; for Physical Functioning, the scores were 70 and 75, and for Role Functioning, 62 and 68, respectively. For Cognitive Functioning, the mean score was 74 and 73; for Emotional Functioning - 62 and 68, and for Social Functioning 64 and 60, respectively. The difference in the arm symptoms domain was significant at 46 and 33 points, respectively (p = 0.004). The patients treated with breast conserving surgery had a better body image than women after amputation - the mean score was 52 and 66, respectively (p = 0.01).

Conclusions. With respect to Global Health Status/QoL and Physical Functioning, the quality of life of women in the early postoperative period was similar in women after breast amputation and those who underwent breast conserving surgery. Patients treated with breast conserving surgery had a better score for body image, while those who underwent amputation more often suffered from arm symptoms, such as pain, oedema, and problems with raising of the limb.
Nd:YAG Laser surgery of lung metastases
Authors: Kirschbaum Andreas
Published: July 2015

Lung metastases occur during the course of the disease in many types of cancer. If the basic disorder is under control and there are no distant or mediastinal lymph node metastases, removal of the lung metastases can improve long-term survival. Lung metastases are non-anatomically removed from the healthy patient if they have not infiltrated any central bronchi or blood vessels. Nd:YAG lasers are particularly suitable for this. They cut the lung parenchyma and at the same time coagulate the resected surface. This means that large numbers of lung metastases can be removed with little bleeding. Modern Nd:YAG lasers (wavelength 1318 nm) are more efficient to use because the laser power is greater (80–100 W). This shortens the operation time and makes the resected surfaces more airtight. Consequently, resection zones on the surface need no longer to be sutured. The mortality and morbidity of the operations are low. Nd:YAG lasers are now indispensable in the surgical treatment of lung metastases.
Case distribution and φ-agreement with Polish genitive of quantification in the feature sharing theory of Agree
Authors: Willim Ewa
Published: July 2015

This paper offers a minimalist account of the distribution of the features of case, number and gender in Polish phrases with cardinal numerals and vague quantifiers (Q-NPs) in the presence and absence of genitive of quantification (GQ) based on the assumption that GQ-cardinal numerals and vague quantifiers are phrasal and are merged as adjuncts to the projection of a null functional head (F), a phase head that values its complement with GQ in contexts in which GQ is not overridden by inherent theta-related or lexical case. Whether the null head F inserted in the derivation has unvalued features of number and gender has consequences for the syntactic computation of agreement relations, in which features may be shared. Heterogeneous case distribution in Q-NPs in nominative-accusative case contexts provides evidence that F is a phase head and triggers transfer of its complement. Variable agreement patterns of both attributive adjectival modifiers and adjectival predicates in the presence of GQ are argued here to reflect attempted-but-failed syntactic agreement, which does not lead to ungrammaticality, as some features unvalued in narrow syntax can still be interpreted by morphological realization rules in PF. GQ is shown here to provide evidence that predicative adjectives cannot have their φ-features valued in situ and must be remerged in a position where their φ-probes can initiate Search for matching features. Agreement in the presence of GQ in Polish thus demonstrates that the need of features to be valued drives syntactic movement.
Regional Employment Growth and Spatial Dependencies in Algeria
Authors: Zouache Abdallah , Belarbi Yacine
Published: July 2015

An analysis of the determinants of Algerian industrial employment growth in a framework that includes a spatial dependency effect reveals that there is no convergence process between the Algerian regions. Nonetheless, a convergence club gathering three wilayates appears when spatial heterogeneity of industrial employment growth is considered. Furthermore, our paper demonstrates that the hydrocarbon and the construction and public works sectors did not have externality effects on local industrial employment growth. Accordingly, Algerian public plans had some impact on unemployment, but mainly on informal unemployment through the support of the construction and public work sector.
Tree Lines
Authors: Cohen Michael P.
Published: July 2015

This collaboration of ink drawings and texts examines the high altitude landscape and forests of the White Mountains, in Eastern California, in particular the bristlecone pine, and a neighboring species, the limber pine and western juniper, and their environs. It is the premise of the writer and artist that drawing and writing about these species and this place fosters a valuable kind of local knowledge, while producing striking works of art and craft.
Bloom
Authors: Goldberg Ken , Krishnan Sanjay , Viégas Fernanda , Wattenberg Martin
Published: July 2015

In Bloom, an Internet-based earth-art-work, minute movements of the Hayward Fault in California are detected by a seismograph, transmitted continuously via the Internet, and processed to generate an evolving field of circular blooms. The size and position of each bloom is based on real-time changes in Earth’s motion, measured as a vertical velocity continuously updated from the seismometer. The horizontal position of blooms is based on time, and their vertical position is based on magnitude of the second derivative or rate of change. Large movements create large blooms; small jitters create tiny buds. This essay presents several stills from the Bloom project, and an essay on the work and its creator, Ken Goldberg.
INDICADORES DE INFLACIÓN SUBYACENTE PARA COSTA RICA BASADOS EN EXCLUSIÓN Y EN REPONDERACIÓN
Authors: Rodríguez Vargas Adolfo , Vega Monge Melissa
Published: July 2015

We evaluate the performance of new core inflation indicators for Costa Rica, computed
through the exclusion or reweighting of the items in the CPI basket. We construct
exclusion indicators based on the elimination of fixed categories of the CPI, as well as
alternative versions of an indicator calculated by excluding articles according to their
volatility, using data updated to December 2012. We also construct two types of reweighted
indicators: one type using volatility measures and the other using persistence measures.
Persistence reweighting is based either on the estimated spectrum of the series of price changes, three indicators based in an autoregressive coefficients methodology, a meanreversion indictor, or an indicator based on the correlation of each series of price changes with variations in future inflation. For each indicator, we evaluate unbiasedness, fit to trend inflation, predictive ability and long-run behaviour. From the results of this evaluation, we recommend monitoring one of the volatility-weighted indicators and one of the persistence-weighted indicators.

 
La gestión del cuidado: una función social y legal de la enfermería chilena
Authors: Ceballos-Vásquez Paula , Jara-Rojas Ana , Stiepovich-Bertoni Jasna , Aguilera-Rojas Pamela , Vílchez-Barboza Vivian
Published: July 2015

Introducción: El objetivo de este ensayo es reflexionar acerca del concepto de gestión en enfermería con el fin de visibilizar a países latinoamericanos que han incorporado la gestión del cuidado a sus normativas, en específico la experiencia chilena y los aspectos legales que rigen la gestión del cuidado.Desarrollo: Para conseguir dicho objetivo, se efectuó una revisión bibliográfica en diversas revistas de corriente principal, textos y leyes relacionadas con el gerenciamiento y la gestión del cuidado. Inicialmente, se analizó el concepto de gestión con la intención de comprender por qué la enfermería lo integra dentro de sus ámbitos de desempeño; luego, se buscó visibilizar cómo algunos países de Latinoamérica han incorporado, dentro de sus marcos legales, la gestión del cuidado a la profesión de enfermería, por último, se analiza la experiencia de la enfermería chilena al respecto.Conclusión: Como consideraciones finales se obtiene que la gestión del cuidado es parte de la función social de las enfermeras/os; por tanto, desempeñar el trabajo diario incorporando lo gerencial, otorgará competencias gestoras y facilitará el cuidado autónomo para tales profesionales.
Maya-K-PDB Software for the Three-Dimensional Modeling and Visualization of the Conformational Dynamics of Biomacromolecules
Authors: Филиппов С.В. , Filippov S.V.
Published: July 2015

The work is devoted to obtaining the bipolaron functional in anisotropic crystals by Buimistrov-Pekar method for an arbitrary electron-phonon coupling. The effect of electron
correlations related to the direct dependence of the wave function from the distance between the electrons on bipolaron energy is studied. The single-center and two-center
(coaxial configuration) bipolaron models in crystals with anisotropic effective mass for the limiting case of quasi-systems (the system “light axis”) were compared.
Olhar para Dentro/Olhar para Fora: Literatura Nacional e Fronteira
Authors: Gomes Renato Cordeiro
Published: July 2015

Cet essai a comme point de départ deux fonnulations sur le statut de la Littérature Brésilienne: l'une de Afrânio Coutinho et l'autre de Antonio Candido. Mises en confrontation, elIes révêlent des positions opposées, quand elIes soutiennent, respectivement, la these du nationalisme et celle du cosmopolitisme. Ces propositions revisent des concepts comme identité, autonomie et dépendance de la littérature nationale, ce qui serait une tentative d'établir une tradition qui aurait la fonne d'une frontiere (ou sa négation). Avec l'aide de la Littérature Comparée, on cherche à mettre en cause la territorialité comme signe de légitimation, engendrée par un systeme en rapport avec son extérieur. On regarde en deçà et au de1à des frontieres, pour signaler des différences culturelles dans le dialogue avec d'autres littératures.
64
Guerra Civil Espanhola na literatura e no cinema dos anos 1990: a idealização da luta revolucionária
Authors: Jaeckel Volker
Published: July 2015

Resumo: No presente artigo pretende-se uma apresentação de três obras de conhecidos autores e diretores europeus (uma literária, duas cinematográficas) dos anos 1990 do século 20, nas quais acontece uma idealização da luta revolucionária durante a Guerra Civil Espanhola. O objetivo deste texto é explicar o surgimento do movimento libertário no início da contenda na região da Catalunha em 1936 e evidenciar as manifestações literárias da glorificação desta batalha na Guerra Civil Espanhola entre anarquistas por um lado e comunistas e republicanos, por outro, estes últimos querendo reverter a situação de coletivização dos bens agrários e industriais.Palavras-chave: Guerra Civil Espanhola; revolução social; memórias na literatura e no cinema.Abstract: In the present article the intention is a presentation of three works of well-known European authors and directors (a literary one, two cinematographic ones) of the Nineties of the 20th century in which an idealization of the revolutionary fight in the Spanish Civil War takes place. The objective of this text is to explain the sprouting of the libertarian movement at the beginning of the dispute in the region of Catalonia in 1936 and to evidence the literary and novelistic manifestations of the glorification of these rivalry battles between anarchists on the one hand and communists and republicans on the other side, the latter of which wanted to revert the situation of socialization of the agrarian and industrial goods.Keywords: Spanish Civil War; Anarchist Social Revolution; Memory in Literature and Film.
Dialética do negaceio: Bildung e cabotinismo na correspondência de Drummond e Mário de Andrade
Authors: Maciel Emílio
Published: July 2015

Resumo: Leitura da correspondência de Drummond e Mário de Andrade, este ensaio expõe e analisa o jogo autobiográfico e ficcional encenado nas cartas, tomando como ponto de partidas as tensões entre engajamento político e autonomia estética.Palavras-chave: autobiografia, comunidade, retórica.Abstract: A reading of the correspondence of Drummond and Mario de Andrade, this essay exposes and analyses the autobiographical and fictional game enacted by the letters, taking as a point of departure the tensions between political engagement and aesthetic autonomy.Keywords:  autobiography, community, rhetoric.
Um crime nas brumas do porto: O polar à la Simenon
Authors: Arbex Márcia
Published: July 2015

Estudo da narrativa O porto das brumas (1932), de Georges Simenon, a partir do exame das características principais do romance policial e da relação do autor com esse gênero, no contexto da literatura francófona. Serão abordadas as estratégias narrativas identificadas na obra, considerando o porto como espaço de encenação do crime, o método intuitivo do comissário de polícia Maigret, bem como a valorização do humanismo dos personagens em sua investigação.
Batucar-cantar-dançar: desenho das performances africanas no Brasil
Authors: Ligiéro Zeca
Published: July 2015

A partir do poderoso trio “batucar-cantar-dançar”, encontrado como característica principal da performance na África negra pelo filósofo do Congo Bunseki Fu-Kiau, o autor analisa os processos da recriação em solo brasileiro das principais performances afro-brasileiras, tanto religiosas como seculares.
APRESENTAR O IRREPRESENTÁVEL: paisagem com bois e vaca amarela
Authors: Glenadel Paula
Published: July 2015

Aproximar o conto de Guimarães Rosa “Conversa de bois”
(Sagarana, 1946) do quadro Vaca amarela (1911), de Franz Marc,pintor expressionista ligado ao movimento Der Blaue Reiter,significa repensar a representação dos animais, forçando os limites do comentário batailliano sobre a “mentira poética da animalidade” até fazer da poesia o lugar de uma verdade ética da hospitalidade com a qual se dá acolhida ao totalmente outro. Essa verdade se manifesta como exigência do impossível, como no dito de Derrida: “Um ato de hospitalidade só pode ser poético.” No conto, coexistem estruturas mais tradicionais de representação com a tentativa poética de encontrar, através da plasticidade da linguagem, algo que seria traço irredutível dos bichos; no quadro, a representação da vaca vista de fora se mistura ao cromatismo em amarelo com o qual o pintor busca apresentar poeticamente algo do afeto dos bichos em sua “visão de mundo”.
Hinos de futebol nas Gerais: dos hinos marciais aos populares
Authors: Cornelsen Elcio Loureiro
Published: July 2015

Baseados na relação entre literatura, música e futebol, propomos a análise de hinos de clubes de futebol de Minas Gerais, enfocando a transição dos hinos marciais das primeiras décadas do século 20 para os hinos populares a partir da década de 1940. Para compor nosso corpus de análise, elegemos o hino marcial e o hino popular do Villa Nova Atlético Clube, da cidade de Nova Lima.
Movimientos ficcionales y no ficcionales de la violencia. Crímenes de mujeres
Authors: Domínguez Nora
Published: July 2015

Los crímenes contra mujeres, que adquieren formas seriales en el contexto de la globalización y la pobreza, son una marca que distingue a los finales del siglo XX y comienzos del XXI. La literatura ha ido a la par de esos datos, proponiéndose como un campo de fuerzas donde la violencia y el terror, sustrato político de estas ficciones, deviene en exploración literaria. A partir del análisis de “La parte de los crímenes” de 2666 de Roberto Bolaño (2004), El trabajo de Aníbal Jarkowski (2007) y Le viste la cara a Dios de Gabriela Cabezón Cámara (2012), este artículo piensa los cuerpos de mujeres como los disparadores narrativos que modulan las versiones político -literarias en las que el intercambio mafioso, la prostitución como amenaza neoliberal o la trata de personas funcionan como núcleos duros de verdades del presente. Los textos literarios afincados en límites verbales no logran colmar la experiencia desnuda del sufrimiento y el dolor, pero manipulan los signos materiales que pueden evocarlos y otorgarles significado.
Hanna Krall e os caminhos tortos da memória e da identidade
Authors: Kilanowski Piotr
Published: July 2015

Neste artigo apresentamos a escritora polonesa de origem judaica Hanna Krall por meio da análise literária do seu romance Sublokatorka (A sublocatária).  O romance, com elementos autobiográficos, apresenta a personalidade cindida de uma menina sobrevivente do Holocausto e discute o tema da identidade polonesa, judaica e judaico-polonesa. Através da observação da memória e do processo de criação da memória, a autora mostra a construção da identidade falsa e a repressão da verdadeira, o comportamento comum entre alguns dos sobreviventes.
El mito clásico a través de la obra teatral de Lourenzo
Authors: Maquieira Helena , Blanco Maria Eugenia Rodríguez
Published: July 2015

En el presente trabajo se aborda el análisis de dos obras teatrales del autor gallego contemporáneo Manuel Lourenzo, Fedra y Últimas faíscas de Setembro. Ambas tratan, desde una perspectiva distinta, las figuras míticas de Fedra y Medea. En el caso de Fedra, Lourenzo hace un tratamiento muy respetuoso del mito y de la obra de Séneca. En el de Medea, la actualización del mito que lleva a cabo el autor implica profundas transformaciones.
O Feminino corpo da negrura
Authors: Martins Leda Maria
Published: July 2015

A produção poética e ficcional de escritoras negras brasileiras é o objeto de perquirição deste texto, no qual são sublinhados elementos que, na construção discursiva, produzem novas e engenhosas possibilidades de referências figurativas e temáticas do feminino corpo da negrura no cenário atual da Literatura Brasileira.
Literatura e psicanálise: repensando a interdisciplinaridade
Authors: Peres Ana Maria Clark
Published: July 2015

Este ensaio tem como objetivo repensar questões relativas à interdisciplinaridade, buscando compreender a interlocução Literatura/Psicanálise enquanto vivência de experiências, ou seja, a partir de uma implicação radical no processo analítico e na leitura de um texto literário.
El cuerpo, el alma y sus metáforas: La llama doble, de Octavio Paz
Authors: Malpartida Juan
Published: July 2015

Este ensayo analiza los conceptos de amor y erotismo
en La llama doble, de Octavio Paz, a partir de incursiones
intertextuales en las obras de Sade, Bataille e Rougemont.
Repensando a Literatura Comparada: Edward Said e Fredric Jameson
Authors: Bellei Sérgio Luiz Prado
Published: July 2015

As obras de Edward Said e Fredric Jameson representam, no contexto da crítica literária e cultural da atualidade, projetos alternativos para restaurar a validade do estudo histórico na leitura de textos, e isto na dimensão de poder globalizante que compreende as culturas metropolitanas e periféricas. Enquanto Jameson tenta situar tais textos em suas desigualdades e no contexto de uma história única e última e do sistema ideológico que os explica de forma mais completa (o Marxismo), Said percebe tais textos a partir da prática relativamente livre do crítico que, em precário equilíbrio entre cultura e sistema de pensamento e munido de uma ética humanitária de valor universal, tenta produzir uma leitura em contraponto dirigida para a percepção das histórias do outro cultural reprimidas pelas estratégias discursivas imperiais.
Der Prozess e a Arte - Anotações para uma poética de Kafka
Authors: Castro Manuel Antônio
Published: July 2015

A leitura interpretativa que o presente estudo faz de O Processo afasta-se das interpretações tradicionais. Os fundamentos metafísicos que deram origem aos gêneros e aos estilos de época são insuficientes para apreenderem a especificidade da obra literária. Eles são substituídos pela própria obra, entendida como processo. Ler poeticamente a obra é fazer eclodir a sua poética. Para tanto, assinalam-se na obra de Kafka três grandes processos: a vida cotidiana, a vida jurídico-institucional, o manifestação do real. A unidade desses três processos é realizada por um quarto: o processo narrativo. A culpa de Joseph K. é lida como a morte que irrompe com a vida, mas da qual o personagem não quer tomar-se consciente. Todo o processo narrativo, do qual resulta O Processo, consiste nesta descoberta abissal e inexorável.
Antígona e o Desejo
Authors: Rosa Sara deI Carmen Rojo de la
Published: July 2015

Este trabalho analisa, a partir dos estudos de gênero, a personagem de Antígona em relação ao desejo. Esta pesquisa está focalizada em três peças: Antígona furiosa, de Griselda Gambaro, Antígona, de Jean Anouilh, e Antígona, de Sófocles.
Anémic Cinéma
Authors: Arbex Márcia
Published: July 2015

Este trabalho apresenta uma experiência cinematográfica de vanguarda, Anémic cinema, realizada por Marcel Duchamp, e tem por objetivo demonstrar que tal experiência resulta de uma reflexão, aprofundada e subversiva ao mesmo tempo, sobre a linguagem, tendo o artista absorvido a poética de Mallarmé, Roussel e Brisset.
Cruz e Sousa: As Expansibilidades do Emparedado
Authors: Fonseca Jair Tadeu
Published: July 2015

Este trabalho examina alguns aspectos da relação entre literatura e “raça” na obra de Cruz e Sousa e em sua recepção crítica. Considerando seu texto “Emparedado” uma expressão poética de identidade cultural, este artigo aproxima a obra de Cruz e Souza do pensamento político de Frantz Fanon.
Causative Alliance between Monetary Policy, Inflation and Inflation Rate at Economic System in Pakistan
Authors: Ibrar Muhammad
Published: July 2015

Purpose: This study examine both the monetary policy and inflation are the issues of high interest and importance, and how thus the studying them and their impact on the extension of the macroeconomic variables is a which are concerned for our culture/society.The purpose of this proposal is focusing to identifying the existing connections between the inflation rate and some important macroeconomic indicators /variables and also on the dynamics of inflation at a national level. The main objective of this study is to reveal the causal relation between the inflation rate and the interest rate of the monetary policy and also between the inflation rate and the unemployment rate,Conclusion: There is an inverse statistically significant relation between the inflation rate and the unemployment rate. This indicates that the inflation rate is an effective instrument in preventing the increase of in unemployment. Monetary policy has demonstrated.
Creation of a vascular system for organ manufacturing
Authors: Liu Libiao , Wang Xiaohong
Published: July 2015

The creation of a vascular system is considered to be the main object for complex organ manufacturing. In this short review, we demonstrate two approaches to generate a branched vascular system which can be printed using rapid prototyping or bioprinting techniques. One approach is constructing mathematical tree models on the basis of human physiological characteristics and calculating the model using constrained constructive optimization to obtain three-dimensional (3D) geometrical structures. The rules of the branching of the vessel tree were extracted from the literature. Another approach is using computer-aided design models to build a multi-scale vascular network including arteries, veins, and capillaries. A 3D vascular template with both synthetic scaffold polymer and cell/hydrogel was created in our group, using a double-nozzle, low-temperature deposition technique. Each of the approaches holds promise in producing a vascular system.
Angiotensin converting enzyme: the antigenic properties of the domain, role in alzheimer's disease and tumor progression
Authors: Kugaevskaya E.V. , Timoshenko O.S. , Solovyeva N.I.
Published: July 2015

Angiotensin converting enzyme (ACE, EC 3.4.15.1) was discovered and characterized in the Laboratory of biochemistry and chemical pathology of proteins under the direction of academician V.N. Orekhovich, where its physiological function, associated with a key role in the regulation of the renin-angiotensin (RAS) and the kallikrein-kinin systems that control blood flow in the body and homeostasis was first deciphered. We carried out a search for structural differences between the two highly homologous domains (N- and C-domains) of somatic ACE (sACE); it was based on a comparative analysis of antigenic determinants (or B-epitopes) of both domains. The revealed epitopes were classified with variable and conserved regions and functionally important sites of the molecule ACE. Essential difference was demonstrated between locations of the epitopes in the N- and C-domains. These data indicate the existence of structural differences between the domains of sACE. We studied the role of the domains of ACE in the metabolism of human amyloid beta peptide (Ab) – the main component of senile plaques, found in the brains of patients with Alzheimer's disease (AD). Our results demonstrated that only N-domain ACE cleaved the Ab between residues R5–H6, while, the C-domain of ACE failed to hydrolyze this region. In addition, the effect of post-translational modifications of Ab on its hydrolysis by the ACE was investigated. We show that isomerization of residue D7, a common non-enzymatic age-related modification found in AD-associated species, does not reduce the affinity of the peptide to the N-domain of ACE, and conversely, it increases. According to our data, the role of ACE in the metabolism of Ab becomes more significant in the development of AD. RAS is involved in malignant transformation and tumor progression. RAS components, including ACE and angiotensin II receptors type 1 (AT1R) are expressed in various human tumors. We found a significant increase in the level of ACE activity in the tumor tissue of squamous cell carcinoma of the cervix. In our viewpoint, the increase in ACE activity may be a marker of poor clinical prognosis.
Bacterial recombinant L-asparaginases: properties, structure and anti-proliferative activity
Authors: Sokolov N.N. , Eldarov M.A. , Pokrovskaya M.V. , Aleksandrova S.S. , Abakumova O.Yu. , Podobed O.V. , Melik-Nubarov N.S. , Kudryashova E.V. , Grishin D.V. , Archakov A.I.
Published: July 2015

For more than 40 years L-asparaginases are used in combined therapy of acute lymphoblastic leukemia in children and the range of tumors sensitive to these enzymes constantly extends. This review summarizes results of studies aimed at creation of new systems for heterological expression of bacterial L-asparaginases as Erwinia carotovora (EwA), Helicobacter pylori (HpA), Yersinia pseudotuberculosis (YpA) and Rhodospirillum rubrum (RrA); special attention is paid to isolation of purified enzymes and their crystallization, modification by chitosan/polyethylene, physicochemical, kinetic and structural properties characterization, and the study of the cytotoxic or anti-proliferative activity of new recombinant L-asparaginases on cell cultures in vitro. The resultant recombinant L-asparaginases (EwA, YpA, HpA и RrA) exhibit reasonable cytotoxic action on the human leukemia cells comparable to the pharmacologically available L-asparaginase EcA and represent practical interest in respect to creation, on their basis, new effective antineoplastic remedies. Further prospects of researches on bacterial L-asparaginases are associated with development of analogs of Rhodospirillum rubrum L-asparaginase (RrA) by means of directed changes of the protein structure using genetic engineering, development of chito-PEGylation for receiving L-asparaginase preparations with improved pharmacokinetic characteristics.
Hedgehog signaling in the pathogenesis of neuro-oncology diseases
Authors: Cherepanov S.A. , Baklaushev V.P. , Gabashvili A.N. , Shepeleva I.I. , Chekhonin V.P.
Published: July 2015

The review summarizes current knowledge on the Hedgehog signaling pathway, its role in normal embryogenesis and/or initiation and progression of neuro-oncological diseases, especially of high-grade gliomas, the most malignant neuroepithelial tumors. The main proteins forming the Hedgehog signaling pathway include Shh, PTCH1, SMO, HHIP, SUFU and GLI1 isoforms. Effects of other signaling pathways on the family of transcription factors GLI and other proteins are described. The review summarizes modern data about the impact of the Hedgehog signaling pathway on proliferation, migration activity and invasiveness, and also on tumor neoangiogenesis and tumor cell chemoresistance. The role of the Hedgehog signaling pathway in origin of cancer stem cells and epithelial-mesenchymal transition is also analyzed. Some prospects for new anticancer drugs acting on components of the Hedgehog signaling pathway inhibitors are demonstrated.
Analysis of proteomic profile changes of zebrafish embryos during exposure to doxorubicin, built-in the phospholipid transport nanosystem
Authors: Samenkova N.F. , Kisrieva Y.S. , Petushkova N.A. , Kuznetsova G.P. , Larina O.V. , Trifonova O.P. , Karuzina I.I. , Ipatova O.M. , Lisitsa A.V.
Published: July 2015

The proteome profile of Danio rerio embryos grown in the medium containing doxorubicin, included in the phospholipid transport nanosystem (doxolip) has been investigated using combination of 1D-electrophoresis with subsequent MALDI-TOF-PMF mass spectrometry. Cultivation of growing of D. rerio embryos in the medium with doxolip caused a substantial increase in expression of the cytoskeletal proteins, a decrease in the number of nuclear proteins involved in DNA and RNA synthesis and disappearance of vitellogenin 2 in comparison with control (the cultivation medium containing the phospholipid transport nanosystem). Analysis of the proteomic profiles of doxolip-treated embryos suggests lower toxicity of doxorubicin incorporated in the phospholipid nanosystem.
Developing a Production Data Management (PDM) System Using Off-the-Shelf Software
Authors: McGinnis B. , Flanders W. A.
Published: July 2015

Most commercial production data management (PDM) systems for microcomputers lack the flexibility to accommodate abnormal situations and frequent change. These problems have been overcome by developing a PDM system using LOTUS 1-2-3, dBASE III PLUS, and GRAPHER. Other comparable software can be used with similar results.
A novel nested dynamic programming (nDP) algorithm for multipurpose reservoir optimization
Authors: Delipetrev Blagoj , Jonoski Andreja , Solomatine Dimitri P.
Published: July 2015

In this article we present a novel nested dynamic programming (nDP) algorithm for multipurpose reservoir optimization with additional decision variables related to different water users. The nDP algorithm is built from two algorithms: (1) dynamic programming (DP) and (2) nested optimization algorithm implemented with Simplex and quadratic Knapsack methods. The novel idea is to include a nested optimization algorithm into the DP transition that reduces the initial problem dimension and alleviates the DP's curse of dimensionality. The nDP can solve multi-objective optimization problems, without significantly increasing the algorithm complexity and the computational expenses. Computationally, the nDP can handle dense and irregular variable discretization; it is coded in Java as a prototype application and has been successfully tested with eight objectives at the Knezevo reservoir in the Republic of Macedonia. The article presents a discussion on comparison of nDP with other DP methods and highlights the advantages of nDP.
Principle Analysis and Parameter Optimization for Uuderactuated End-Effector Manipulator for Apple Picking
Authors: Ya-xin Yu , Fei Wu , Rong Zhu , Fei Zhang
Published: July 2015

In this paper, the mechanical structure of an underactuated end-effector manipulator for apple-picking is
presented. The structure is consisted of three identical fingers which are driven by one motor. Each finger is formed by
three joints which are connected with connecting bar and gears. With operation of grasp and twist executed by the driven
fingers, apple-picking action completed. Mathematical model of the mechanical structure is proposed. Kinematics
simulation & optimization software which have a Human-Computer Interaction interface is developed with Visual Basic
visualization platform. Parameters which affect enveloping space mostly are analyzed. With processing and analyzing
data which get from the software, a set of optimum structure parameters are obtained. A sample machine of the End-effector Manipulator which is used for testing purpose is designed according to the optimum structure parameters.
Multi Tooth Uneven Cutting Behavior of High-speed Milling Cutter and
Criterion for Milled Surface Topography
Authors: Bin Jiang , Guisheng Yao , Shuai Zhang , Tong Xu
Published: July 2015

With the cutting model of high-speed milling cutter in vibration condition, milling cutter vibration and effect of
tooth error on cutting parameter are researched and high-speed milling cutter multi tooth uneven cutting behavior
characterization methods are proposed. Use of high speed milling cutter cutting experiments and simulation results of
surface topography, processing surface morphology characteristic parameters of cutter multi-tooth uneven cutting
behavior response characteristics are revealed under the influence of milling cutter vibration and error, surface topography
criterion is established in the cutting behavior of high speed milling cutter with multi-tooth, judgment method of multitooth
uneven cutting behavior of high speed milling cutter with multi-tooth is proposed. Use the above criteria and
evaluation method, reveal the formation mechanism of multi tooth uneven cutting, proposed compensation method of
multi tooth uneven cutting behavior of high-speed milling cutter and do an experiment to verify the method.
Experimental Study and Numerical Simulation of Injection Molding Process
for Special-shaped Plastic Part
Authors: Xiaoyong Chen , Qian Wang
Published: July 2015

Taking the special-shaped plastic part as the research object, experimental study and numerical simulation of
injection molding process were performed using numerical simulation technology, orthogonal experiment method, software
Moldflow, injection machine and coordinate measuring machine (CMM). The better feeding system and optimal
molding process parameters were proposed and qualified products were produced. The research results show that the efficiency
of the simulation guidance would be significantly improved by combining the CAE technology and production experience.
Clinical Characteristics and Outcome of Primary Sjogren’s Syndrome: A
Large Asian Indian Cohort
Authors: Sandhya Pulukool , Jeyaseelan Lakshmanan , Scofield Robert Hal , Danda Debashish
Published: July 2015

Objective :

To characterise the clinical features, immunological profile and outcome in a cohort of Asian Indian patients with primary Sjögren's syndrome (SS).

Methods :

Electronic medical records from a tertiary care teaching hospital in south India were screened for SS between 2004 and 2011. Patients fulfilling American European Consensus group (AECG) 2002 or American College of Rheumatology (ACR) 2012 classification criteria were included. Agglomerative hierarchical cluster analysis to identify patterns of associations between clinical and immunological features was done. Multivariate logistic regression to identify predictors of major systemic involvement was performed. Data on treatment and outcome were retrieved from electronic records.

Results :

Of 423 patients suspected to have SS, 332 fulfilled inclusion criteria. Only 8.3% of patients complained of sicca symptoms on their own at initial presentation. Younger age of onset, higher female to male ratio, paucity of cryoglobulinemia, Raynaud’s phenomenon and hyperglobulinemia were unique to this cohort. Cluster analysis revealed two subsets: The first cluster comprised of patients having a major systemic illness with high antibody titers and the second comprised of seronegative patients with mild disease. Over a third of SS cases had severe systemic manifestations necessitating treatment with immunosuppressants. In multivariate logistic regression analysis, anti-Ro and anti-La antibody positivity was associated with higher odds for systemic disease features (OR=2.67, P=0.03 and OR=3.25, P=0.003, respectively) whereas chronic pain was associated with lower odds (OR=0.4, p=0.032). Clinical improvement including symptomatic benefit in sicca and musculoskeletal features was noted with immunomodulators in the majority.

Conclusion :

Our cohort of patients with SS has characteristic clinical features; some of them are in contrast with previous observations reported in European patients. This cohort consisted of two distinct patient clusters. The first cluster was associated with major systemic illness and high antibody titers, where as the second cluster comprised of seronegative patients with mild disease. Association of antibody positivity with systemic features was further confirmed on logistic regression analysis.