bluuebunny/crossref_metadata_2025 huggingface dataset:
ICON-P - A prospective double-blind evaluation of quality improvements with Individualized CONstraints from low-cost knowledge-based radiation therapy planning in Prostate cancer
Authors: Saha Saheli , Pras S Sriram , Balakrishnan Arun , Kalita Smita Jagadish , Elavarasan Niranjan , Adhya Debashree Guha , Sarkar Arnab , Arunsingh Moses , Chakraborty Santam , Mallick Indranil
Published: September 2022

PURPOSE/OBJECTIVE(S)
A low-cost, prior knowledge-based individualized dose-constraint generator for organs-at-risk has been developed for prostate cancer radiation therapy (RT) planning. In this study, we aimed to prospectively evaluate the feasibility and improvements in organs-at-risk (OAR) doses in prostate cancer RT planning using this tool served on a web application.
MATERIALS AND METHODS:
A set of previously treated prostate cancer cases planned and treated with generic constraints were prospectively replanned using individualized dose constraints derived from a library of cases with similar volumes of target, OAR, and overlap regions and served on the web-based application. The goal was to assess the reduction in mean dose, specified dose volumes (V59Gy, V56Gy, V53Gy, V47Gy, and V40Gy), and generalized equivalent uniform dose (gEUD) to the rectum and bladder. Planners and assessors were blinded to the initial achieved doses and penalties. Sample size estimation was based on improvement in V53Gy for the rectum and bladder with a paired evaluation.
RESULTS:
Twenty-four patients were prospectively replanned. All the plans had a PTV D95 of at least 97% of the prescribed dose. The individualized OAR constraints could be met for 87.5% of patients for all dose levels. The mean dose, V59Gy, V53Gy, and V47Gy for the bladder was reduced by 7.5Gy, 1.12%, 5.51%, and 10.53% respectively. Similarly for the rectum, the mean dose, V59Gy, V53Gy, V47Gy and was reduced by 5.5Gy, 4.34%, 6.97%, and 11.61% respectively. All dose reductions were statistically significant. The gEUD of the bladder was reduced by 2.47Gy (p <0.001) and the rectum by 3.21Gy (p <0.001).
CONCLUSION:
Treatment planning based on individualized dose constraints served on a web application is feasible and leads to improvement at clinically important dose volumes in prostate cancer RT planning. This application can be served publicly for improvements in RT plan quality.
A new rotating machinery fault diagnosis method for different speeds based on improved multivariate multiscale fuzzy distribution entropy
Authors: Ma Yanli , Cheng Junsheng , Wang Ping , Wang Jian , Yang Yu
Published: September 2022

To abstract the fault features from multivariate vibration signals of the rotating machinery under different speeds, an improved multivariate multiscale fuzzy distribution entropy (IMMFDE) is proposed. Based on multivariate empirical mode decomposition (MEMD), the IMMFDE can determine the maximum scale adaptively, meanwhile eliminate the frequency aliasing and avoid the loss of potentially useful information in the multiscale process. The trait of IMMFDE is verified by calculating the sequences and their amplitude spectrums at each scale of the simulated multivariate signals. Further, the fault diagnosis method is proposed for the rotating machinery under different speeds based on IMMFDE. In the method, the statistical parameters (SPs) and IMMFDE are calculated as fault feature set, then support vector machine (SVM) is used for fault diagnosis. Applying the method to two types of the rotating machinery multi-fault diagnosis under different speeds, the results show the proposed method can obtain better fault diagnosis results.
Safety and Efficacy of Paclitaxel plus Carboplatin Versus Paclitaxel plus Cisplatin in Neoadjuvant Chemoradiotherapy for Patients with Locally Advanced Esophageal Carcinoma : A Retrospective Study
Authors: Jiang Li , Zhu Jie , Chen Xue , Wang Yi , Wu Lei , Wan Gang , Han Yongtao , Leng Xuefeng , Peng Lin , Wang Qifeng
Published: September 2022

Background and purpose
We evaluated and compared the efficacy and safety of chemotherapy with paclitaxel plus cisplatin (TP) or carboplatin (TC) in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC) who underwent neoadjuvant chemoradiotherapy (NCRT).
Materials and methods
This single-center retrospective study assessed patients with LA-ESCC (cT2N + M0, cT3-4aNanyM0) receiving NCRT plus curative-intent esophagectomy with TP or TC regimen. The primary endpoints were grade ≥ 3 adverse events (AEs) and overall survival (OS). AEs were compared using a t-test according to CTCAE 4.0. The Kaplan-Meier survival curves were compared using the log-rank test; the treatment effect was measured using hazard ratios (HR) and 95% confidence intervals (CI).
Results
We included 151 and 50 patients in the TC and TP groups, respectively. Baseline demographic and clinical characteristics were well balanced between groups. The TP group exhibited significantly higher hematologic and non-hematologic AEs than the TC group, and the noticeable difference was the incidence of febrile neutropenia of grade 3 or higher (P = 0.011). No significant intergroup differences were noted considering postoperative complications, resection margins, or pathological complete remission rate (all P > 0.05). OS and progression-free survival (PFS) did not significantly differ between groups. The estimated 3-year OS and PFS rates were 65.1% versus 69.4% and 58.4% versus 53.5% for TP and TC groups, respectively.
Conclusion
In patients with LA-ESCC, we recommend TC, not TP, as an optimal chemotherapy regimen for NCRT, given its superiorsafety profile and comparable efficacy.
Employment Demand Mining and Talent Training Enlightenment Based on Recruitment Data：Taking as an example Statistics
Authors: Yan Chun , Yang Lijuan , Liu Wei
Published: September 2022

To help candidates understand the specific needs of the market for talents, and provide references for education institutions to develop training programs and curricula. Scraping the recruitment data on the 51Job website with statistics as the keyword. After cleaning and labeling them, comparing the entity recognition effects of BiLSTM-CRF, BiGRU-CRF, BERT-BiLSTM-CRF, and BERT-BiGRU-CRF, and then selecting the best model to extract recruitment entities for mining analysis. The experimental results show that the BERT-BiGRU-CRF model has the best recognition effect, and the accuracy value and F1 value are increased by 7.05% and 4% respectively, which has certain advantages over the other three models. According to the selected recruitment entities, the skills and qualities that the statistics profession should possess are summarized from the three aspects of educational background, professional requirements, and personal qualities, and suggestions on training for statistics education are put forward.
An Efficient Data Compression Algorithm
Authors: Dey Swapan
Published: September 2022

This paper introduces a new and highly efficient data compression algorithm, which is a variant of Lempel-Ziv group of algorithms but much more efficient than other variants of Lempel-Ziv algorithm. Unlike popular data compression tools (zip, rar, 7z, gzip, bzip etc) available in the market that use multiple data compression algorithms together to achieve optimum compression, this algorithm alone is capable of compressing a data much better than deflate[8] (zip) for most of the files > 10–12 MB without using any other data compression technology at the second level, hence leaves enough opportunity for the researchers to achieve much better compression in future by using an entropy algorithm along with the proposed algorithm.
Multisystem Inflammatory Syndrome in Children and SARS-CoV-2 variants: a two-year ambispective multicentric cohort study in Catalonia, Spain.
Authors: Pino Rosa , Antoñanzas Jesús M , Paredes-Carmona Fernando , Perramon Aida , Rivière Jacques G , Coma Maria , Martínez-Mejías Abel , Ripoll Francesc , López Nuria , Conti Romina , Sala Pere , Ruiz Montserrat , Brio Sonia , García-Lorenzo Marc , Esteller Maria , Carreras-Abad Clara , Herrero-Hernando Carlos , Schneider Stephan Otto , Gatell Anna , Aguilar Isabel , Cantero Javier , Ruiz Gloria , Fenollosa Teresa , Lobato Zulema , Villalobos Pilar , Mora Emiliano , Anton Jordi , Visa-Reñé Nuria , Soler-Palacin Pere , Calavia Olga , Esqu Cristina , Guarch-Ibáñez Borja , García-García Juan José , Coma Ermengol , Fina Francesc , Prats Clara , Soriano-Arandes Antoni
Published: September 2022

Purpose
Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe disease temporarily related to SARS-CoV-2. We aimed to describe the epidemiological, clinical and laboratory findings of all the MIS-C cases diagnosed in children < 18 years-old in Catalonia (Spain) to study their trend throughout the pandemic.
Methods
Multicenter ambispective observational cohort study (April 2020-April 2022). Data were obtained from the COVID-19 Catalan surveillance system and from all the hospitals in Catalonia. We analyzed MIS-C cases regarding SARS-CoV-2 variants for demographics, symptoms, severity, monthly MIS-C incidence, ratio between MIS-C and accumulated COVID-19 cases, and associated rate ratios (RR).
Results
Among 555,848 SARS-CoV-2 infections, 152 children were diagnosed with MIS-C. Monthly MIS-C incidence was 4.1 (95%CI: 3.4–4.8) per 1,000,000 people, and 273 (95%CI: 230–316) per 1,000,000 SARS-CoV-2 infections (i.e., one case per 3,700 SARS-CoV-2 infections). During the Omicron period, MIS-C RR was 8.2 (95%CI: 5.7–11.7) per 1,000,000 SARS-CoV-2 infections, significantly lower (p < 0.001) than for previous variant periods, in all age groups. Median [IQR] age of MIS-C was 8 [4–11] years, 62.5% male, and 80.2% without comorbidities. Common symptoms were gastrointestinal findings (88.2%) and fever > 39oC (81.6%), nearly 40% had an abnormal echocardiography and 7% coronary aneurysm. Clinical manifestations and laboratory data were not different throughout the variant periods (p > 0.05).
Conclusions
The rate ratio between MIS-C cases and SARS-CoV-2 infections was significantly lower in the Omicron period for all the age groups, including those not vaccinated, suggesting that the variant could be the main factor for this shift in the MISC trend. Regardless of variant type, the patients had similar phenotypes and severity throughout the pandemic.
Multi-Coefficient Eigenmode Operation – Breaking Through 10°/hr Open-Loop Bias Instability in Wideband Aluminum Nitride Piezoelectric BAW Gyroscopes
Authors: Liu Zhenming , Wen Haoran , Ayazi Farrokh
Published: September 2022

This paper introduces a modification to the eigenmode operation of resonant gyroscopes. The so-called multi-coefficient eigenmode operation can improve cross-mode isolation due to spatially non-orthogonal imperfection, which is one of the causes of residual quadrature error in conventional eigenmode operation. A 1400µm annulus aluminum nitride (AlN) on Silicon bulk acoustic wave (BAW) resonator with gyroscopic in-plane bending modes at 2.98MHz achieves near 60dB cross-mode isolation when operated as a gyroscope using multi-coefficient eigenmode architecture. The as-born frequency mismatches in multiple devices are compensated by physical laser trimming as an alternative to the displacement feedback tunning mechanism. The demonstrated AlN piezoelectric BAW gyroscope shows a large open-loop bandwidth of 150Hz and a high scale factor of 9.5nA/°/s on a test board in a vacuum chamber. The measured angle random walk is 0.145°/√hr, and the bias instability is 8.6°/hr, showing significant improvement compared to the previous eigenmode AlN BAW gyroscope. The result from this paper proves that with multi-coefficient eigenmode operation, the piezoelectric AlN BAW gyroscopes can have a comparable noise performance as their capacitive counterpart while having the unique advantage of large open-loop bandwidth and not requiring large DC polarization voltages.
Captivity, reintroductions, and the rewilding of the amphibian microbiome
Authors: Korpita Timothy , Muths Erin , Watry Mary Kay , McKenzie Valerie
Published: September 2022

The authors have requested that this preprint be removed from Research Square.
Efficacy of floating needles in the treatment of postpartum Urinary incontinence and pain: A systematic review and meta-analysis
Authors: Tang Min , Gong Shuang , Li Wanyi , Liu Zhitao , Liu Zicai , Han Dongmiao
Published: September 2022

Background: Postpartum pain and urinary incontinence are the most common postpartum sequelae, which can lead to postpartum anxiety and depression when severe, and seriously affect the quality of life of postpartum mothers. Floating needle as one of the Chinese medical treatments of the latest in recent years, studies have shown that floating needle for postpartum pain and stress incontinence (UI) has a positive effect, this study aimed to comprehensively and critically evaluate the available evidence on the effectiveness of floating needle in managing postpartum pain and UI, and provide the first evidence-based medical evidence for floating needle intervention for postpartum sequela.
Methods: Computer retrieval of Chinese databases: CNKI, Wanfang database, Chongqing VIP Full-text Database, China Biomedical Literature Database, and English database: PubMed, Embase, Web of Science, Cochrane Library, randomized controlled trial of the floating needle in the treatment of postpartum pain and urinary incontinence, search date: March 20, 2022. Keywords: floating needle, urinary incontinence, labor pain, postpartum pain, etc. Search all relevant articles in English and Chinese. Data extraction and quality evaluation were carried out for the literature that met the inclusion criteria, and a meta-analysis was conducted for the included literature data using RevMan5.4 statistical software.
Results： A total of 1194 women were included in 8 articles in Both Chinese and English, all of which were conducted in China, 6 of the articles were included in the meta-analysis. The floating needle is more effective in treating postpartum incontinence and pain than the control group[RR=1.33, 95%CI(1.18,1.5), P＜0.00001], and can significantly reduce the IC-IQ-SF score of postpartum incontinence and pain patients [MD=1.56, 95%CI(0.78,2.35), P＜0.0001], floating needle therapy can significantly reduce the amount of urine leakage in postpartum patients[MD=1.79, 95%CI(1.09,2.49), P＜0.00001].
Conclusions： Floating needles significantly reduced postpartum pain and improved stress urinary incontinence, but did not improve pelvic floor muscle strength. Like kegel, we encourage the use of floating needles in clinical practice as one of the routine treatments for postpartum sequelae.
High level of HDGF expression in hepatocellular carcinoma: a potential therapeutic target associated with prognosis and immune infiltration
Authors: Wang Jianlei , Chen Xiaolei , Xia Tong , Liu Zeyang , Song Jianping , Ma Delin , Liu Yanfeng
Published: September 2022

Background
Evaluations of hepatoma-derived growth factor (HDGF) expression may possess prognostic value for several cancers, including hepatocellular carcinoma (HCC). However, its functions and underlying mechanisms in HCC remain to be elucidated. The current study was designed to investigate the expression patterns of this protein, its prognostic value, immune characteristics and potential molecular mechanisms of HDGF in HCC.
Methods
Clinical and gene expression data were collected. The Kaplan–Meier method, time-dependent receiver operating characteristic (ROC) curves, and Cox regression analysis were used to analyze the prognostic value of HDGF. Differences in HDGF expression were analyzed using DESeq2 in R and gene ontology, KEGG, and GSEA were used to determine the biological functions of HDGF. Both the estimate and SsGSEA methods were used to analyze the immune infiltrates of HCC. Illumina human methylation 450 data and level 3 HTSeq-FPKM data from TCGA-LIHC cohort were used to determine the effects of DNA methylation on HDGF expression.
Results
HDGF was overexpressed in HCC and its expression correlated with T stage, pathological stage, histological grade, and AFP levels. Furthermore, we revealed the HDGF acts as an independent risk factor for overall survival in HCC and its expression is associated with the tumor-immune microenvironment and immune infiltration, especially in terms of cytotoxic, pDC and Th2 cell populations. Our data also suggests increased HDGF expression in HCC is associated with demethylation of its promoter region.
Conclusions
HDGF independently predicts unfavorable prognosis and regulates the immune microenvironment of HCC, identifying HDGF as a potential immunotherapeutic target for HCC.
Optimization of Organic-Inorganic Perovskite Solar Cell Layers
Authors: Hussain Chnar I. , Hassan Yousif M. , Abed Frh A.
Published: September 2022

Obtaining cheap Electronic Transparent Materials (ETM) and Hole Transparent Materials (HTM) is an important challenge for researchers in perovskite solar cells. we used the SCAPS software in order to determine the properties of CH3NH3SnI3-based solar cells with different ETM and HTM layers, such as (IGZO, SnO2, TiO2, ZnO) and (Spiro-OMeTAD, NiO, Cu2O, and CuO), respectively. Our results predict that among these ETMs, the SnO2 is the most promising to result in high photovoltaic (PV) efficiency in combination with Spiro-OMeTAD based HTM. In addition the perovskite absorber's thicknesses are optimized to achieve maximum photovoltaic efficiency. In order to increase efficiency, layer thickness in cell structures can be optimized by fixing the thickness of the first two layers while altering the thickness of the third. The perovskite solar cell's planar structure consists of ETM (SnO2)/perovskite absorber (CH3NH3SnI3) / HTM (Spiro-OMeTAD)/ and Gold (Au) as a back contact. Also, it improved the solar cell performance by optimizing the absorber thickness, which was 1 µm. With these considerations, the power conversion efficiency of 33.2698% is obtained. Also, we explore the effect of the defect at the perovskite/SnO2 interface on solar cell performance.
Oxidation behavior and outward diffusion of Al along oxide grain boundaries of FeCrAl alloys overdoped with Zr and Hf by means of Atom Probe Tomography (APT)
Authors: Daradkeh Samer I. , Boll Torben , Mousa Marwan S. , Sobola Dinara
Published: September 2022

It is generally accepted that the formation of α-Al2O3 scale on FeCrAl alloys is governed by inward oxygen transport along grain boundaries. However, it metal ion outward diffusion plays a role in the development of the oxide scales and their microstructural characteristics. This paper studies oxidation behavior and outward diffusion for iron-chromium alloys containing ~ 10 at. % aluminum, ~ 22 at. % Chromium, occurred when doped with an over-critical concentration of reactive elements, i.e. Zr and Hf. All samples were investigated after thermal exposure at 1100°C by Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Atom Probe Tomography (APT). As a result of the overdoping, a considerable increase in oxide growth, an increase in the depth of internal oxidation, and RE-oxide formation near and at oxide Grain Boundaries (GBs) were observed as a consequence of increased inward and outward diffusion. The effect of overdoping manifests itself differently depending on the RE type and amount due to different solubility, ionic size, and electronic structure. The overdoped sample with Zr is the retainment of the adhesion of alumina to the alloy after the first and second thermal exposure, contrary to Hf overdoping which leads to severe spallation after the second thermal exposure. And FeCrAl-Zr overdoped sample formed ZrO at oxide grain boundary and internal Al oxide.
Comparison of the effect of propolis vaginal gel and metronidazole oral tablet on wet smear test results in women suffering from trichomoniasis
Authors: Taghavian Shadi , Beiranvand Reza , Valiani Mahboubeh , Alian Siamak , Yekdaneh Afsaneh , Tehrani Hatav Gasemi , Zafarbakhah Azam , Brojeni Tahere Khalili
Published: September 2022

Background and objective: Trichomoniasis is the most common non-viral sexually transmitted infection. One of the methods for diagnosing trichomoniasis is a wet smear test. Propolis has anti-parasitic properties are due to its components, namely tannins, flavonoids, and volatile oils. The present study was performed to compare the effect of a vaginal gel containing propolis extract with that of a metronidazole oral tablet on the wet smear test results in women suffering from trichomoniasis.
Material and method: The present clinical trial was performed on 102 married non-pregnant women with trichomoniasis, who were referred to obstetrics and gynecology clinics in Isfahan from September 15 to January 20, 2020. The patients were assigned into two groups of intervention and control randomly. Both groups underwent treatment for 7 days. Wet smear was taken from the patients three times (i.e. initial visit, first follow-up, and second follow-up) and the samples were observed under Carl Zeiss single-lens microscope. Data were analyzed using SPSS (version 20) at a significance level of 0.05.
Results: Two groups did not differ significantly in terms of baseline characteristics. In the first post-treatment follow-up, the chance of a negative wet smear test result was 4.41 times greater in the intervention group than in the control group. Given the control of the baseline characteristics, this chance was 5.8 times greater. In addition, it was found that the chance of a negative wet smear test result in the second follow-up was affected by the wet smear test result in the first follow-up.
Conclusion: Based on the results of this study, it can be concluded that vaginal gel containing 7.5% propolis extract was more efficient than standard treatment in eradicating infection and preventing the recurrence of infection.
Nishanbaevite, KAl2O(AsO4)(SO4), a new As/S-ordered arsenate-sulfate mineral of fumarolic origin 1
Authors: Pekov Igor V. , Zubkova Natalia V. , Yapaskurt Vasiliy O. , Belakovskiy Dmitry I. , Britvin Sergey N. , Agakhanov Atali A. , Turchkova Anna G. , Sidorov Evgeny G. , Kutyrev Anton V. , Blatov Vladislav A. , Pushcharovsky Dmitry Yu.
Published: September 2022

A new mineral nishanbaevite, ideally KAl2O(AsO4)(SO4), was found in sublimates of the Arsenatnaya fumarole at the Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. It is associated with euchlorine, alumoklyuchevskite, langbeinite, urusovite, lammerite, lammerite-β, ericlaxmanite, kozyrevskite, and hematite. Nishanbaevite occurs as long-prismatic or lamellar crystals up to 0.03 mm typically combined in brush-like aggregates and crusts up to 1.5 mm across. It is transparent, colourless, with vitreous lustre. Dcalc = 3.011 g cm− 3. Nishanbaevite is optically biaxial (–), α = 1.552, β ≈ γ = 1.567. The chemical composition (average of seven analyses) is: Na2O 3.79, K2O 8.01, CaO 0.10, CuO 0.21, Al2O3 30.08, Fe2O3 0.50, SiO2 1.62, P2O5 0.66, As2O5 32.23, SO3 22.59, total 99.79 wt.%. The empirical formula calculated based on 9 O apfu is: (K0.57Na0.41Ca0.01)Σ0.99(Al1.99Fe3+0.02Cu0.01)Σ2.02(As0.95S0.95Si0.09P0.03)Σ2.02O9. Nishanbaevite is orthorhombic, Pbcm, a = 15.487(3), b = 7.2582(16), c = 6.6014(17) Å, V = 742.1(3) Å3 and Z = 4. The strongest reflections of the powder XRD pattern [d,Å(I)(hkl)] are: 15.49(100)(100), 6.56(30)(110), 4.653(29)(111), 3.881(54)(400), 3.298(52)(002), 3.113(29)(121), and 3.038(51)(202, 411). The crystal structure, solved from single-crystal XRD data (R = 7.58%), is unique. It is based on the complex heteropolyhedral sheets formed by zig-zag chains of Al-centred polyhedra (alternating trigonal bipyramids AlO5 and octahedra AlO6 sharing edges) and isolated tetrahedra AsO4 and SO4. Adjacent chains of Al polyhedra are connected via AsO4 tetrahedra to form a heteropolyhedral double-layer. Its topological peculiarity is considered and compared with those in structurally related compounds. The (K,Na) site is located in the interlayer space between SO4 tetrahedra. The position of nishanbaevite among the arsenate-sulfates and their specific structural features are discussed. The mineral is named in honour of the Russian mineralogist Tursun Prnazorovich Nishanbaev (1955–2017).
An approach to chemical hardness through Shannon's entropy
Authors: Flores-Gallegos Nelson , Flores-Gómez Leonardo
Published: September 2022

Shannon's entropy is a concept that has been present in the field of theoretical chemistry since the early 70s, its versatilityhas permitted associate this concept with the chemical reactivity theory. In this work, we present a development that relates Shannon'sentropy with chemical hardness, the equations obtained were applied to a set of 1641 molecules, based on our results, it was possible to write a relationship between Shannon's entropy and the chemical hardness.
The clinic pathological and immunohistochemical features of breast carcinomas with signet-ring-cell differentiation
Authors: Zheng Jie , Liu Junlin , Yang Wan , Yao Jia , Guo Jiao , Liu Changqing
Published: September 2022

Background
This study investigated the clinicopathological features, immunophenotypic characteristics and differential diagnosis of primary breast carcinomas with signet ring cell differentiation, as well as differences in signet ring-like cell mucin traits.
Methods
A total of five cases of primary breast cancer with signet ring cell differentiation diagnosed and treated in The First People’s Hospital of Jingmen from January 2016 to December 2021 were collected. HE, immunohistochemical staining and AB-PAS staining were used to analyze.
Results
Although we have strictly selected all cases of primary breast cancer with signet ring cell differentiation, but there are differences in the arrangement of cells and the grading of nuclei. Immunohistochemical
Evaluate the necessity of autumn irrigation on salinized soil by considering change in soil physicochemical properties
Authors: Zhao Hang , Wu Jingwei , Li Changsen , Liu Yawen , Zhang Rui , Zhao Qiang
Published: September 2022

Agricultural irrigation is an effective way to control soil salinization in cold/arid regions. Specifically, autumn irrigation before soil freezes can inhibit the salt accumulation that occurs on the soil surface from freezing and thawing. However, changes in planting structure have resulted in farmers no longer conducting autumn irrigation, which may exacerbate the degree of soil salinization should this continue. Because autumn irrigation is very important for farmland management strategies, this study set up three management measures, autumn irrigation, no autumn irrigation and straw mulching, to evaluate the need to conduct autumn irrigation on salinized soil based on soil physicochemical properties. The results showed that autumn irrigation increased the soil water storage after thawing by 3.36×10− 2 m, soil salt storage increases were low, and the topsoil salinization grade did not change. However, with no autumn irrigation and straw mulching, the salt storage at 0–20 cm increased by 178.08% and 133.44%, respectively, and the topsoil became intensely salinized. Compared with that before freezing, the decrease in total soil porosity with autumn irrigation was smaller, but autumn irrigation exacerbated the fragmentation of large soil aggregates. The ≥ 0.3–100 µm pore size was reduced by 12.23% and 7.43% with no autumn irrigation and straw mulching, respectively, and the structure and function showed a degradation trend. Conversely, autumn irrigation improved soil water retention. The structural equation model further showed that autumn irrigation positively impacted the physicochemical properties of saline soil. This study provides new insights into mitigating salinization and developing farmland management measures.
Orelabrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Patients: Multi-center, Single-arm, Open-label, Phase 2 Study
Authors: Li Jianyong , Xu Wei , Zhou Keshu , Wang Tingyu , Yang Shenmiao , Liu Lihong , Hu Yu , Zhang Wei , Ding Kaiyang , Zhou Jianfeng , Gao Sujun , Xu Bing , Zhu Zunmin , Liu Ting , Zhang Huilai , Hu Jianda , Ji Chunyan , Wang Shunqing , Xia Zhongjun , Wang Xin , Li Yan , Song Yongping
Published: September 2022

Background
Orelabrutinib is a novel, small molecule, selective irreversible Bruton’s tyrosine kinase inhibitor. The aim of this study was to evaluate the efficacy as well as safety in patients with refractory or relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma (R/R CLL/SLL).
Methods
This is single-arm, multi-center, open-label, phase 2 study in 80 eligible Chinese patients, who were treated with monotherapy of orelabrutinib at 150 mg once daily. Overall response rate (ORR) that was evaluated by an independent review committee (IRC) was set as the study’s primary endpoint, with progression-free survival (PFS), overall survival (OS), and safety as the study’s major secondary endpoints.
Results
IRC-assessed ORR was 92.5% (74/80); complete response 21.3% (17/80), partial response 60.0% (48/80), partial response with lymphocytosis 11.3% (9/80). At a 32.3-month median follow-up (mFu), the median PFS had not been achieved, while the 30-month PFS rate and OS rate were 70.9% (95% confidence interval [CI], 59.5-79.6) and 81.3% (95% CI, 70.8-88.2), respectively. Orelabrutinib also revealed substantial response in patients with high prognostic risks: ORRs of patients carrying positive TP53 mutational status or del(17p), del(11q), as well as unmutated immunoglobulin heavy-chain variable region gene (IGHV) were 100%, 94.7%, and 93.9%, respectively. Most adverse events (AEs) were in low grade, with 86.8% of AEs being Grade 1 or 2. Nearly 67% of patients were still receiving orelabrutinib after almost a 3-year follow-up.
Conclusions
Orelabrutinib demonstrated compelling efficacy as well as safety profiles, with a noteworthy number of patients obtaining complete response in R/R CLL/SLL.
Trial registration
The study (NCT03493217) has been registered at ClinicalTrials.gov.
Breast Cancer With Increased Drug Resistance, Invasion Ability, and Cancer Stem Cell Property Through Metabolism Reprogramming
Authors: Chong Kian-Hwee , Chang Yao-Jen , Hsu Wei-Hsin , Tu Ya-Ting , Chen Yi-Ru , Lee Ming-Cheng , Tsai Kuo-Wang
Published: September 2022

Breast cancer is a heterogeneous disease, and the survival rate of patients with breast cancer strongly depends on their stage and clinicopathological features. Chemoradiation therapy is commonly employed to improve the survival of patients with advanced breast cancer. However, the treatment process is often accompanied by the development of drug resistance, which eventually leads to treatment failure. Metabolism reprogramming has been recognized as a mechanism of breast cancer resistance. In this study, we established a doxorubicin-resistant MCF-7 (MCF-7-D500) cell line through a series of long-term doxorubicin in vitro treatments. Our data revealed that MCF-7-D500 cells exhibited increased multiple-drug resistance, cancer stemness, and invasiveness compared with parental cells. We analyzed the metabolic profiles of MCF-7 and MCF-7-D500 cells through liquid chromatography-mass spectrometry. We observed significant changes in 25 metabolites, of which 21 exhibited increased levels (> 1.5-fold change and P < .05) and 4 exhibited decreased levels (< 0.75-fold change and P < .05) in MCF-7-D500. These results suggest the involvement of metabolism reprogramming in the development of drug resistance in breast cancer, especially the activation of glycolysis, the tricarboxylic acid (TCA) cycle, and the hexamine biosynthesis pathway (HBP). Furthermore, most of the enzymes involved in glycolysis, the HBP, and the TCA cycle were upregulated in MCF-7-D500 cells and contributed to the poor prognosis of patients with breast cancer. Our findings provide new insights into the regulation of drug resistance in breast cancer, and these drug resistance-related metabolic pathways can serve as targets for the treatment of chemoresistance in breast cancer.
IL-6 and cfDNA monitoring throughout COVID-19 hospitalisation are accurate markers of its outcomes
Authors: Bello Salvador , Lasierra Ana Belen , López-Vergara Lucía , de Diego Cristina , Torralba Laura , de Gopegui Pablo Ruiz , Lahoz Raquel , Abadía Claudia , Godino Javier , Cebollada Alberto , Jimeno Beatriz , Bello Carlota , Tejada Antonio , Torres Antoni
Published: September 2022

Background: Severe COVID-19 entails a dysregulated immune response, most likely inflammation related to a lack of virus control. A better understanding of immune toxicity, immunosuppression balance, and COVID-19 assessments could help determine whether distinct clinical presentations are driven by specific types of immune responses. The progression of the immune response and tissular damage could predict outcomes and may help in the management of patients.
Methods: We collected 201 serum samples from 93 hospitalised patients classified as moderately, severely, and critically ill. We differentiated the viral, early inflammatory, and late inflammatory phases and included 72 patients with 186 samples in separate stages for longitudinal study as well as 55 controls. We studied selected cytokines, P-selectin, and the issue damage markers lactate dehydrogenase (LDH) and cell-free DNA (cfDNA).
Results TNF-α, IL-6, IL-8, and G-CSF were associated with severity and mortality, but only IL-6 increased since admission in the critical patients and non-survivors, correlating with damage markers. The lack of a significant decrease in IL-6 levels in the critical patients and non-survivors in the early inflammatory phase (a decrease present in the other patients) suggests that these patients did not achieve viral control on days 10–16. For all patients, lactate dehydrogenase and cfDNA levels increased with severity, and cfDNA levels increased in the non-survivors from the first sample (p=0.002) to the late inflammatory phase (p=0.031). In the multivariate study, cfDNA was an independent risk factor for mortality and ICU admission.
Conclusions: The distinct progression of IL-6 levels in the course of the disease, especially on days 10-16, was a good marker of progression to critical status and mortality and could guide the start of IL-6 blockade. cfDNA was an accurate marker of severity and mortality from admission and throughout COVID-19 progression.
A Methodology for the Study of Interspecific Cohabitation Issues in City
Authors: DELAHAYE Pauline
Published: September 2022

The present article will introduce a proposition of semiotic methodology that can be used to diagnose cohabitation issues in cities between human inhabitants and non-animal liminals. This methodology is built on a few sets of data that should be easy to obtain in any important city, and can therefore be utilised in a variety of situations. The different sets of data allow us to map the semiosphere (following Hoffmeyer’s meaning of the term) of the cohabitation situation along three axes: the materiality of the situation, the symbolic value of the relationship, and the emotional value of the interaction. These three aspects allow us to see gaps, paradoxes and points of consistency, enabling of complex and multi-level understanding of the situation.
A Rare but Sinister Cause of Shoulder Pain: A Case Report
Authors: Wang Ting
Published: September 2022

BACKGROUND: Large cell neuroendocrine carcinoma (LCNEC) is a highly aggressive but rare cancer, especially when it first presents as shoulder pain. However, shoulder pain as a possible initial manifestation of lung cancer has been frequently reported.
CASE PRESENTATION: An 84-year-old male, an ex-smoker, presented with left shoulder pain for two weeks. On examination, his clinical findings showed minor rotator cuff pathology and cervical spine degenerative changes. However, 6 months later, he was diagnosed of primary LCNEC lung cancer.
CONCLUSION: The potential aetiologies of shoulder pain in a lung cancer case include: 1) Pain due to tumour invasion or supraclavicular lymph nodes compression of the brachial plexus; 2) Somatic referred pain due to stimulation of phrenic nerve or cervical structure; 3) Pain due to shoulder metastatic disease; 4) Radicular pain due to lower cervical nerve root impingement. Smoking and past cancer history should draw attention and lead to early investigations and regular follow-up reviews. Cautious interpretations of clinical examination and imaging findings are essential to increase diagnostic accuracy.
Preoperative telemedicine visits are as efficient as in-person appointments in avoiding unnecessary cancellation of elective surgical procedures
Authors: Duckworth Janeen Wills - , Dennis Jacqueline , Harrop Catriona , Hoshowsky Victoria Maria , Merli Geno , Weitz Howard , Patel Pious D.
Published: September 2022

Background: The COVID-19 pandemic has presented many challenges in health care, not the least of which was the need to find alternatives to an in-person evaluation in order to reduce the risk of transmission of the virus. Despite the discontinuation of elective procedures at Thomas Jefferson University Hospital in Philadelphia, Pennsylvania in March 2020, there was a subset of patients that required urgent surgical procedures. Consequently, there needed to be a different approach to the presurgical assessment of these patients. At our institution teleconsultation had gained acceptance by patients and providers prior to the COVID-19 pandemic, therefore a program was rapidly developed utilizing teleconsultation to assess these patients. The question we sought to answer was, in patients undergoing surgery, does completing the preoperative surgical consult through teleconsultation affect the cancellation rate on the day of surgery?
Method: A retrospective quantitative study was performed analyzing data from February 2019 to March 2021. The data collected from EPIC included the medical record number, DOB, gender, planned surgical case, and reason for cancellation on the day of surgery. The measured outcome was the visit cancellation rate pre and post-teleconsultation implementation. Two one-sided tests (TOST) were used to validate the equivalence of the two means.
Results: The cancellation rates pre and post-implementation remained low and any difference was not statistically significant.
Conclusion: Using teleconsultation as a substitute for in person evaluation did not impact the rate of same day surgical cancellation. This study suggests that teleconsultation may be a viable alternative to in person evaluation prior to surgery.
Formation Of TiO2/Natural Melanin Nanostructure: Synthesis, Characterization, Optical, Thermal and Magnetic Investigations
Authors: Madkhali nawal , Algessair Saja
Published: September 2022

Recently, with the progress of research in amending and developing the properties of inorganic materials, researchers have become focused on using inexpensive and environmentally friendly materials such as organic materials from natural sources that have proven effective in improving the properties of materials in various applications. In recent years, melanin has become an attractive topic for researchers due to its distinctive structural properties that have been distinguished in multiple application fields. Investigated the structural, morphology, optical, and thermal properties of TiO2 nanoparticles doped with natural eumelanin extracted from the herbal source. We report the use of ultrasonicationunder UV radiation for synthesis. The influence of natural melanin on the structural, optical and thermal properties of TiO2 nanoparticles was investigated by using Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and UV–Vis spectroscopy. It was observed that incorporating natural melanin on TiO2 nanoparticles (TiO2-Mel) occurred at approximately2.01 eV with a low value of Urbach energy around 100 meV indicating improvement in the crystalline structure. Magnetic measurement at room temperature showed diamagnetic behaviour for all samples. This feature can be used to control the superconducting property of titanium dioxide. Furthermore, thermalresults showed that TiO2-Mel is stable even with temperatures up to 400°C. According to the results obtained by the thermal stability of melanin with titanium dioxide, it can be a good candidate in many applications such as solar cells and optoelectronic that require optical efficiency and thermal stability for long periods.
Çok Katmanlı Malzemelerde Açısal Renk Değişimleri ve Işıltı Etkilerinin Analizi
Authors: MİR Sermet , YILDIRIM Barış , KURT Murat
Published: September 2022

Çok katmanlı malzemeler, her bir katmanı farklı bir saçılım davranışına sahip olabilen ve katmanları içerisinde anizotropik davranışa sahip bileşenler barındıran malzeme yapılarıdır. Çok katmanlı malzemeler kozmetik, mücevher ve araba boyası endüstrilerinde yoğun olarak kullanılmaktadır. Ayrıca, bir çok gerçek dünya malzemesi kompozisyon içeriğinde açısal renk değişimi (goniochromatic) ve ışıltı (sparkle) etkilerine neden olan mikroskobik parçacıklar içerir. Bu sebeple, malzemenin gerçekçi görselleştirmesini sağlamak için malzemenin doğru temsil edilmesi büyük önem arz etmektedir ve bu doğrultuda bir çok model önerilmiştir. Bu makalede, çok katmanlı modern araba boyası malzemesi baz alınarak, malzemenin üzerinde görülen açısal renk değişimleri ve ışıltı etkilerini modelleyebilen çalışmaların analizi yapılmış ve deneysel karşılaştırmalar ile modellerin örnek malzemeleri doğru temsil etme kapasiteleri karşılaştırılmıştır. Ek olarak, çalışmamız içerisinde modellerin performans değerleri de karşılaştırılarak deneysel çalışmalarımız içerisinde bu bilgiler paylaşılmıştır. En son kısımda ise bir tablo halinde analizi yapılan çalışmaları içerdikleri karmaşık özel etkileri özetleyerek, okuyucuların bilgisine sunmaktayız.
Shift scheduling study to minimize the risk of contracting virus at COVID-19 units in a pandemic hospital
Authors: EREN AKYOL Derya , HAYIRLIOĞLU Ayşen , TAŞTAN Begümsu , DEMİRSOY Berna , SARI Muharrem
Published: September 2022

Çin’in Wuhan kentinde ortaya çıkan COVID-19 virüsü, dünya genelinde yayılarak artmaya devam etmektedir. Virüsün hızla yayılmasından en çok etkilenen sektör, sağlık sektörü olmuştur. Çalışma alanları itibariyle en riskli ortamda olan sağlık çalışanları, gerekli koruyucu ekipmanları kullansalar dahi uzun süreli ve dengeli düzenlenmemiş çalışma saatlerine bağlı olarak, virüse yakalanma riskini minimize edememektedirler. Aynı zamanda sağlık çalışanlarının koronavirüse yakalanma riski, hastanelerde açılan korona servisi birimleriyle de doğrudan etkileşim içerisindedir. Yapılan çalışmada, belirli varsayımlar üzerine kurulmuş simülasyon modelinden alınan veriler doğrultusunda korona servisi birimleri ile doktor ve hemşirelerin virüse yakalanma riskini minimize edecek bir tam sayılı doğrusal programlama (TDP) modeli önerilmiştir. Planlama ufku 14 gün olarak belirlenmiş ve model sonucunda korona servisi birimleri için virüs taşıma riskinin minimum olduğu vardiya çizelgeleri oluşturulmuştur.
Biyomedikal Uygulamalar için Çok Noktalı Çok Boyutlu İvmeölçer Veri Kayıt Sistemi
Authors: AKKAN Taner , ŞENOL Yavuz , ÖZGÖREN Murat
Published: September 2022

Bazı biyomedikal sinyal işleme uygulamaları, özel veri kaydı donanımı gerektirir. Diz ile ilgili non-invaziv teşhis ve çene ile ilgili elektroensefalografi (EEG) bozunum temizleme uygulamaları, eşzamanlı çok kanallı titreşim veri kaydı gerektiren iyi adaylar olacaktır. Bu çalışmada, yeni bir çok noktalı çok boyutlu ivme veri kayıt sistemi önerilmiştir. Bu sistem ivmeölçerler kullanarak aynı anda üç farklı noktadan üç boyutlu eğilim ve titreşim verilerini toplamaktadır. Çok kanallı sinyal analizi, sensör verilerini filtrelemek ve bileşenlerine ayırmak için eşzamanlı veri kayıtları gerektirir. Seçilen ivmeölçer, aynı anda üç eksen veri kaydı gerekliliğini sağlamaktadır. İvmeölçer veri kayıt sistemi, teşhis desteği için dizden ve EEG çene bozunum temizleme desteği için çeneden eğilim ve titreşim verileri elde etmek için kullanılabilir. Diz hareketlerinin titreşimlerini (vibroartrografik (VAG) sinyaller) tespit etmek için diz kapağı ve yan pozisyonlara üç ivmeölçer yerleştirilebilir. Elde edilen VAG sinyalleri, istatiksel veya zaman-frekans analiz teknikleri ile değerlendirilebilir. Ayrıca çene ve boyun hareketlerini kaydetmek için yüze üç adet ivmeölçer yerleştirilmiştir. Eş zamanlı olarak kaydedilen EEG ve çene verileri, istenmeyen boyun ve çene bozunumlarını çıkarmak için filtreleme veya istatistik yöntemler ile daha ileri bir şekilde analiz edilebilir.
The Dynamic Effects of Stator Turn-to-Turn Short Circuit Fault on the Electrical, Mechanical and Magnetical Motor Parameters in Induction Motors
Authors: AKBAYIR Kürşad , GÖKTAŞ Taner , ARKAN Müslüm
Published: September 2022

In this study, the dynamic effect of stator turn-to-turn short-circuit fault on electrical, mechanical and magnetic motor parameters is investigated in detail. For this purpose, the Finite Element Method (FEM) based ANSYS@Maxwell-2D program is used, which enables steady state and transient analysis. The changes in stator current and induced back electromotive force voltage from electrical parameters, output torque from mechanical variables and leakage flux from magnetic parameters are examined in detail in both time and frequency axis by means of Fast Fourier Transform (FFT) for the faulty state. Moreover, in order to detect stator turn-to-turn fault, stray flux analysis is carried out and characteristics fault signatures are defined. The obtained results and findings have been proven through the developed experimental setup in laboratuvary.
Defne Yaprağı ve Adaçayı İçeren Yenilebilir Filmler: Oksidasyonun Engellenmesi ve Soğukta Muhafa Pişmiş Köftelere Uygulanması
Authors: AKCAN Tolga , SERDAROĞLU Meltem
Published: September 2022

Bu çalışmanın amacı, defne yaprağı (D, Laurus nobilis L.) veya adaçayı (S, Salvia officinalis) ekstraktları ile birleştirilen peynir altı suyu proteini izolatı bazlı yenilebilir filmlerin 7 gün boyunca 2°C'de soğutularak saklanan pişmiş dana köftelerinin oksidatif değişiklikleri üzerindeki etkisini belirlemektir. S-EF'li köftelerin TBA değerleri, EF. D-EF’li köftelerin TBA değerlerinden daha düşük olduğu bulunmuştur, SA-F, 2,2’-diphenyl-2-picrylhydrazyl radikal yakalama metoduna (DPPH) göre D-EF, S-EF ve EF gruplarından daha fazla antioksidan aktivite göstermiştir. Toplam fenolik bileşik içeriği, ekstrakt eklenmiş yenilebilir film gruplarında, ekstrakt eklenmemiş yenilebilir film gruplarına göre daha önemli ölçüde artmıştır.
Yenilebilir filmlere (EFs) D veya S'dan elde edilen doğal antioksidan ekstraktlarının dahil edilmesi, pişmiş köftelerde çeşitli yöntemlerle ölçülen lipid oksidasyonunun derecesini önemli ölçüde azaltmıştır (p