bluuebunny/crossref_metadata_2025 huggingface dataset:
A Repair Method for Damage in Aluminum Alloy Structures with the Cold Spray Process
Authors: Han Xiaohui , Sun Xiaoguang , Li Gangqing , Huang Shiming , Zhu Ping , Shi Chunyuan , Zhang Tengfei
Published: November 2021

Aluminum alloy structures may be damaged due to wear or corrosion while in service. These damages will bring about huge financial costs, as well as a huge amount of energy consumption. There is an urgent need to search for an appropriate repair method in order to solve this problem. In this research, the cold spray process was used to repair the damages by using a mixture of powders with Al and Al2O3. A 7N01-T4 aluminum alloy plate with a factitious pit was regarded as the damaged sample. The microstructure, mechanical properties, and corrosion behavior were studied. The results showed that there were no visible perforative pores or cracks in the repaired areas. The microhardness of the repaired areas was in the range of 57.4–63.2 HV and was lower than that of the 7N01-T4 aluminum alloy. The tensile strength of the repaired samples was markedly improved compared with the unrepaired samples. The alternate immersion test results indicated that the repaired samples had the lowest rate of mass loss compared with 7N01-T4 and the unrepaired samples. After alternate immersion tests for 504 h, the repaired samples were covered with dense corrosion products. The repaired samples had a superior corrosion resistance compared to that of 7N01-T4. Thus, the cold spray process is a method of repairing damage in aluminum alloy structures.
Three-Dimensional Bending Analysis of Multi-Layered Orthotropic Plates by Two-Dimensional Numerical Model
Authors: Pluciński Piotr , Jaśkowiec Jan , Wójtowicz Maciej
Published: November 2021

The paper presents effective numerical modelling of multi-layered plates with orthotropic properties. The method called the FEM23 is employed to construct the numerical model. The approach enables a full 3D analysis to be performed while using a 2D finite element mesh. The numerical model for a multi-layered plate is constructed by an assembling procedure, where each layer with orthotropic properties is added to the global numerical model. The paper demonstrates that the FEM23 method is very flexible in defining the multilayered plate, where the thickness of each layer as well as its mechanical orthotropic properties can be defined independently. Several examples of three-layered or nine-layered plates are analyzed in this paper. The results obtained by the FEM23 method coincide with the ones taken from the published papers or calculated with the standard 3D FEM approach. The orthotropic version of the FEM23 can be quite easily applied for other kinds of problems including thermo-mechanics, free vibrations, buckling analysis, or delamination.
Correction: Poljak, M.; Matić, M. Metallization-Induced Quantum Limits of Contact Resistance in Graphene Nanoribbons with One-Dimensional Contacts. Materials 2021, 14, 3670
Authors: Poljak Mirko , Matić Mislav
Published: November 2021

The authors regret that the results presented in Figure 3c,d and Figure 6c,d in our published paper [...]
Testing and Modelling of Elastomeric Element for an Embedded Rail System
Authors: Li Qianqian , Corradi Roberto , Di Gialleonardo Egidio , Bionda Stefano , Collina Andrea
Published: November 2021

Modelling of elastomeric elements of railway components, able to represent stiffness and damping characteristics in a wide frequency range, is fundamental for simulating the train–track dynamic interaction, covering issues such as rail deflection as well as transmitted forces and higher frequency phenomena such as short pitch corrugation. In this paper, a modified non-linear Zener model is adopted to represent the dependences of stiffness and damping of the rail fastening, made of elastomeric material, of a reference Embedded Rail System (ERS) on the static preload and frequency of its deformation. In order to obtain a reliable model, a proper laboratory test set-up is built, considering sensitivity and frequency response issues. The equivalent stiffness and damping of the elastomeric element are experimentally characterised with force-controlled mono-harmonic tests at different frequencies and under various static preloads. The parameters of the non-linear Zener model are identified by the experimental equivalent stiffness and damping. The identified model correctly reproduces the frequency- and preload-dependent dynamic properties of the elastomeric material. The model is verified to be able to predict the dynamic behaviour of the elastomeric element through the comparison between the numerically simulated and the experimentally measured reaction force to a given deformation time history. Time domain simulations with the model of the reference ERS demonstrate that the modelled frequency- and preload-dependent stiffness and damping of the elastomeric material make a clear difference in the transient and steady-state response of the system when distant frequency contributions are involved.
Cement Paste Mixture Proportioning with Particle Packing Theory: An Ambiguous Effect of Microsilica
Authors: Niewiadomski Paweł , Karolak Anna , Stefaniuk Damian , Królicka Aleksandra , Szymanowski Jacek , Sadowski Łukasz
Published: November 2021

Recently, the research of innovative building materials is focused on applying supplementary materials in the form of micro- and nanopowders in cementitious composites due to the growing insistence on sustainable development. Considering above, in paper, a research on the effect of microsilica and SiO2 nanoparticles addition to cement paste, designed with Andreasen and Andersen (AA) packing density model (PDM), in terms of its physical and mechanical properties was conducted. Density, porosity, compressive strength, hardness, and modulus of indentation were investigated and compared regarding different amount of additives used in cement paste mixes. Microstructure of the obtained pastes was analyzed. The possibility of negative influence of alkali-silica reaction (ASR) on the mechanical properties of the obtained composites was analyzed. The results of the conducted investigations were discussed, and conclusions, also practical, were presented. The obtained results confirmed that the applied PDM may be an effective tool in cement paste design, when low porosity of prepared composite is required. On the other hand, the application of AA model did not bring satisfactory results of mechanical performance as expected, what was related, as shown by SEM imaging, with inhomogeneous dispersion of microsilica, and creation of agglomerates acting as reactive aggregates, what as a consequence caused ASR reaction, crack occurrence and lowered mechanical properties. Finally, the study found that the use of about 7.5% wt. of microsilica is the optimum in regards to obtain low porosity, while, to achieve improved mechanical properties, the use of 4 wt. % of microsilica seems to be optimal, in the case of tested cement pastes.
Study on Creep Damage of Ni-Based Superalloy Caused by Variable Load Conditions at Elevated Temperatures
Authors: Wee Sunguk , Kim Keekeun , Park Kibum , Seok Changsung
Published: November 2021

Higher fatigue and creep resistance at high temperatures are the essential properties for materials such as those used in gas turbines for power generation and aircraft turbines. Therefore, the nickel-based superalloy CMSX-4 was developed through single-crystal casting to satisfy these requirements. In this study, the CMSX-4 creep test results reported by previous researchers were used to mathematically derive an equation to estimate the amount of creep damage occurring under variable load conditions. In addition, low-cycle fatigue tests were performed, and the effect of creep damage occurring during fatigue on material failure was described.
Structurally Dependent Electrochemical Properties of Ultrafine Superparamagnetic ‘Core/Shell’ γ-Fe2O3/Defective α-Fe2O3 Composites in Hybrid Supercapacitors
Authors: Bazaluk Oleg , Hrubiak Andrii , Moklyak Volodymyr , Moklyak Maria , Kieush Lina , Rachiy Bogdan , Gasyuk Ivan , Yavorskyi Yurii , Koveria Andrii , Lozynskyi Vasyl , Fedorov Serhii
Published: November 2021

The paper presents a method for obtaining electrochemically active ultrafine composites of iron oxides, superparamagnetic ‘core/shell’ γ-Fe2O3/defective α-Fe2O3, which involved modifying sol-gel citrate synthesis, hydrothermal treatment of the formed sol, and subsequent annealing of materials in the air. The synthesized materials’ phase composition, magnetic microstructure, and structural, morphological characteristics have been determined via X-ray analysis, Mossbauer spectroscopy, scanning electron microscopy (SEM), and adsorption porometry. The mechanisms of phase stability were analyzed, and the model was suggested as FeOOH → γ-Fe2O3 → α-Fe2O3. It was found that the presence of chelating agents in hydrothermal synthesis encapsulated the nucleus of the new phase in the reactor and interfered with the direct processes of recrystallization of the structure with the subsequent formation of the α-Fe2O3 crystalline phase. Additionally, the conductive properties of the synthesized materials were determined by impedance spectroscopy. The electrochemical activity of the synthesized materials was evaluated by the method of cyclic voltammetry using a three-electrode cell in a 3.5 M aqueous solution of KOH. For the ultrafine superparamagnetic ‘core/shell’ γ-Fe2O3/defective α-Fe2O composite with defective hematite structure and the presence of ultra-dispersed maghemite with particles in the superparamagnetic state was fixed increased electrochemical activity, and specific discharge capacity of the material is 177 F/g with a Coulomb efficiency of 85%. The prototypes of hybrid supercapacitor with work electrodes based on ultrafine composites superparamagnetic ‘core/shell’ γ-Fe2O3/defective α-Fe2O3 have a specific discharge capacity of 124 F/g with a Coulomb efficiency of 93% for current 10 mA.
Thermal Modeling of the Port on a Refining Furnace to Prevent Copper Infiltration and Slag Accretion
Authors: Aguilar Francisco José Jiménez-Espadafor , Vélez Godiño José Antonio , Torres García Miguel , Gallardo Fuentes José María. , Díaz Gutiérrez Eduardo
Published: November 2021

Fire refining of blister copper is a singular process at very high temperatures (~1400 K), which means the furnace is exposed to heavy thermal loads. The charge is directly heated by an internal burner. The impurities in the charge oxidize with the flux of hot gases, creating a slag layer on the top of the molten bath. This slag is periodically removed, which implies liquid metal flowing through the furnace port. To address its malfunction, a re-design of the furnace port is presented in this work. Due to the lack of previous technical information, the convective heat transfer coefficient between the slag and the furnace port was characterized through a combination of an experimental test and a three-dimensional transient model. Finally, the original design of the furnace port was analyzed and modifications were proposed, resulting in a reduction of the average temperature of the critical areas up to 300 K. This improvement prevents the anchoring of the accretion layer over the port plates and the steel plate from being attacked by the copper.
Effect of SRB and Applied Potential on Stress Corrosion Behavior of X80 Steel in High-pH Soil Simulated Solution
Authors: Xu Congmin , Gao Haoran , Zhu Wensheng , Wang Wenyuan , Sun Can , Chen Yueqing
Published: November 2021

The effect of SRB and applied potential on the stress corrosion sensitivity of X80 pipeline steel was analyzed in high-pH soil simulated solution under different conditions using a slow strain rate tensile test, electrochemical test, and electronic microanalysis. The experimental results showed that X80 pipeline steel has a certain degree of SCC sensitivity in high-pH simulated solution, and the crack growth mode was trans-granular stress corrosion cracking. In a sterile environment, the SCC mechanism of X80 steel was a mixture mechanism of anode dissolution and hydrogen embrittlement at −850 mV potential, while X80 steel had the lowest SCC sensitivity due to the weak effect of AD and HE; after Sulfate Reducing Bacteria (SRB) were inoculated, the SCC mechanism of X80 steel was an AD–membrane rupture mechanism at −850 mV potential. The synergistic effect of Cl− and SRB formed an oxygen concentration cell and an acidification microenvironment in the pitting corrosion pit, and this promoted the formation of pitting corrosion which induced crack nucleation, thus significantly improving the SCC sensitivity of X80 steel. The strong cathodic polarization promoted the local corrosion caused by SRB metabolism in the presence of bacteria, whereby the SCC sensitivity in the presence of bacteria was higher than that in sterile conditions under strong cathodic potential.
Application of Smart Materials in the Actuation System of a Gas Injector
Authors: Mieczkowski Grzegorz , Szpica Dariusz , Borawski Andrzej , Diliunas Saulius , Pilkaite Tilmute , Leisis Vitalis
Published: November 2021

This paper presents the results of research related to the selection of materials for passive and active components of a three-layer piezoelectric cantilever converter. The transducer is intended for use in a low-pressure gas-phase injector executive system. To ensure the functionality of the injector, its flow characteristics and the effective range of valve opening had to be determined. Therefore, a spatial model of the complete injector was developed, and the necessary flow analyses were performed using computational fluid dynamics (CFD) in Ansys Fluent environment. The opening and closing of the injector valve are controlled by a piezoelectric transducer. Thus, its static electromechanical characteristics were found in analytical form. On this basis, the energy demand of the converter, required to obtain the desired valve opening, was determined. Assuming a constant transducer geometry, 40 variants of material combinations were considered. In the performed analyses, it was assumed that the passive elements of the actuator are made of typical materials used in micro-electromechanical systems (MEMSs) (copper, nickel, silicon alloys and aluminum alloys). As for the active components of the converter, it was assumed that they could be made of polymeric or ceramic piezoelectric materials. On the basis of the performed tests, it was found that the energy demand is most influenced by the relative stiffness of the transducer materials (Young’s modulus ratio) and the piezoelectric constant of the active component (d31). Moreover, it was found that among the tested material combinations, the transducer made of silicon oxide and PTZ5H (soft piezoelectric ceramics) had the lowest energy consumption.
Study on the Mechanical and Leaching Characteristics of Permeable Reactive Barrier Waste Solidified by Cement-Based Materials
Authors: Chen Xuan , Feng Wenkui , Wen Hao , Duan Wei , Suo Chongxian , Xie Mingxing , Dong Xiaoqiang
Published: November 2021

The durability against wet-dry (w-d) cycles is an important parameter for the service life design of solidified permeable reactive barrier (PRB) waste. This study introduces the potential use of cement, fly ash, and carbide slag (CFC) for the stabilization/solidification (S/S) of PRB waste. In this study, solidified PRB waste was subjected to different w-d cycles ranging in times from 0 to 10. By analyzing the mass loss, the unconfined compressive strength (UCS), initial resistivity (IR), and the Mn2+ leaching concentration under different durability conditions, the results demonstrate that these variables increased and then tended to decrease with the number of w-d cycles. The UCS of contaminated soil is significantly correlated with IR. Moreover, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and X-ray diffraction (XRD) analyses indicate that the hydration products calcium silicate hydrate (C-S-H) and ettringite (AFt) are the main reasons for the enhancement of the UCS. However, the increase in Mn2+ concentration leads to a decrease in hydration products and the compactness of solidified soil, which has negative effects for the UCS and the leaching ion concentration. In general, the durability exhibited by the PRB waste treated with S/S in this paper was satisfactory. This study can provide theoretical guidance for practical engineering applications.
Seismic Response Mitigation of a Television Transmission Tower by Shape Memory Alloy Dampers
Authors: Wu Jingbo , Chen Bo , Zhi Lunhai , Song Xinxin
Published: November 2021

High-rise television transmission towers are of low damping and may vibrate excessively when subjected to strong earthquakes. Various dynamic absorbers and dampers are proposed to protect television transmission towers from excessive vibrations and damages. Up to now, the seismic damage reduction in television towers, using SMA dampers under seismic excitations, has not been conducted. To this end, the response reduction in a flexible television tower, disturbed by earthquakes using SMA dampers, is conducted in this study. A two-dimensional dynamic model is developed for dynamic computation at first. The mathematical model of an SMA damper is proposed, and the equations of motion of the tower, without and with, are established, respectively. The structural dynamic responses are examined in the time and the frequency domain, respectively. The effects of damper stiffness, service temperature, hysteresis loops, and earthquake intensity on control efficacy are investigated in detail. In addition, the power spectrum density curves, of dynamic responses and the energy responses, are compared to provide deep insights into the developed control approach. The control performance of SMA dampers is compared with that of widely-used friction dampers. The analytical observations indicate that SMA dampers with optimal parameters can substantially reduce the vibrations of TV transmission towers under seismic excitations.
Surface Modification to Modulate Microbial Biofilms—Applications in Dental Medicine
Authors: Holban Alina-Maria , Farcasiu Catalina , Andrei Oana-Cella , Grumezescu Alexandru Mihai , Farcasiu Alexandru-Titus
Published: November 2021

Recent progress in materials science and nanotechnology has led to the development of advanced materials with multifunctional properties. Dental medicine has benefited from the design of such materials and coatings in providing patients with tailored implants and improved materials for restorative and functional use. Such materials and coatings allow for better acceptance by the host body, promote successful implantation and determine a reduced inflammatory response after contact with the materials. Since numerous dental pathologies are influenced by the presence and activity of some pathogenic microorganisms, novel materials are needed to overcome this challenge as well. This paper aimed to reveal and discuss the most recent and innovative progress made in the field of materials surface modification in terms of microbial attachment inhibition and biofilm formation, with a direct impact on dental medicine.
Factoring the Modulus of Type N = p2q by Finding Small Solutions of the Equation er − (Ns + t) = αp2 + βq2
Authors: Asbullah Muhammad Asyraf , Rahman Normahirah Nek Abd , Ariffin Muhammad Rezal Kamel , Salim Nur Raidah
Published: November 2021

The modulus of type N=p2q is often used in many variants of factoring-based cryptosystems due to its ability to fasten the decryption process. Faster decryption is suitable for securing small devices in the Internet of Things (IoT) environment or securing fast-forwarding encryption services used in mobile applications. Taking this into account, the security analysis of such modulus is indeed paramount. This paper presents two cryptanalyses that use new enabling conditions to factor the modulus N=p2q of the factoring-based cryptosystem. The first cryptanalysis considers a single user with a public key pair (e,N) related via an arbitrary relation to equation er−(Ns+t)=αp2+βq2, where r,s,t are unknown parameters. The second cryptanalysis considers two distinct cases in the situation of k-users (i.e., multiple users) for k≥2, given the instances of (Ni,ei) where i=1,…,k. By using the lattice basis reduction algorithm for solving simultaneous Diophantine approximation, the k-instances of (Ni,ei) can be successfully factored in polynomial time.
Influence of MHD Hybrid Ferrofluid Flow on Exponentially Stretching/Shrinking Surface with Heat Source/Sink under Stagnation Point Region
Authors: Anuar Nur Syazana , Bachok Norfifah , Pop Ioan
Published: November 2021

The numerical investigations of hybrid ferrofluid flow with magnetohydrodynamic (MHD) and heat source/sink effects are examined in this research. The sheet is assumed to stretch or shrink exponentially near the stagnation region. Two dissimilar magnetic nanoparticles, namely cobalt ferrite, CoFe2O4 and magnetite, Fe3O4, are considered with water as a based fluid. Utilizing the suitable similarity transformation, the governing equations are reduced to an ordinary differential equation (ODE). The converted ODEs are numerically solved with the aid of bvp4c solver from Matlab. The influences of varied parameters on velocity profile, skin friction coefficient, temperature profile and local Nusselt number are demonstrated graphically. The analysis evident the occurrence of non-unique solution for a shrinking sheet and it is confirmed from the analysis of stability that only the first solution is the stable solution. It is also found that for a stronger heat source, heat absorption is likely to happen at the sheet. Further, hybrid ferrofluid intensifies the heat transfer rate compared to ferrofluid. Moreover, the boundary layer separation is bound to happen faster with an increment of magnetic parameter, while it delays when CoFe2O4 nanoparticle volume fraction increases.
Nullcone Fronts of Spacelike Framed Curves in Minkowski 3-Space
Authors: Li Pengcheng , Pei Donghe
Published: November 2021

The investigation of objects in Minkowski space is of great significance, especially for those objects with mathematical and physical backgrounds. In this paper, we study nullcone fronts, which are formed by the light rays emitted from points on a spacelike curve. However, if the spacelike curve is singular, then we cannot use the usual tools and methods to study related issues. To solve these problems, we show the definition of spacelike framed curves in Minkowski 3-space, whose original curves may contain singularities. Then, the singularities of the nullcone fronts are characterized by using framed curvatures of spacelike framed curves. Finally, we exhibit some examples to illustrate our results.
Neuron-Specific Enolase (NSE) Predicts Long-Term Mortality in Adult Patients after Cardiac Arrest: Results from a Prospective Trial
Authors: Müller Jonas , Bissmann Benjamin , Becker Christoph , Beck Katharina , Loretz Nina , Gross Sebastian , Amacher Simon A. , Bohren Chantal , Pargger Hans , Tisljar Kai , Sutter Raoul , Marsch Stephan , Hunziker Sabina
Published: November 2021

Background: We investigated whether Neuron-specific enolase (NSE) serum concentration predicts long-term mortality and poor neurological outcome in adult cardiac arrest patients. Methods: Within this prospective observational study, we included consecutive adult patients admitted to the intensive care unit (ICU) after cardiac arrest. NSE was measured upon ICU admission and on days 1, 2, 3, 5 and 7. Results: Of 403 patients, 176 (43.7%) survived. Median follow-up duration was 43.7 months (IQR 14.3 to 63.0 months). NSE levels on day 3 were increased more than threefold in non-survivors compared to survivors (median NSE (ng/mL) 19.8 (IQR 15.7 to 27.8) vs. 72.6 (IQR 26 to 194)) and showed the highest prognostic performance for mortality compared to other days of measurement, with an AUC of 0.81 and an adjusted hazard ratio of 1.55 (95% CI 1.41 to 1.71, p < 0.001). Subgroup analysis showed an excellent sensitivity and negative predictive value of 100% of NSE in patients <54 years of age. Conclusion: NSE measured three days after cardiac arrest is associated with long-term mortality and neurological outcome and may provide prognostic information that improves clinical decision making. Particularly in the subgroup of younger patients (<54 years), NSE showed excellent negative predictive value.
An Assessment of Renewable Energies in a Seawater Desalination Plant with Reverse Osmosis Membranes
Authors: Leon Federico , Ramos Alejandro
Published: November 2021

The purpose of our study was to reduce the carbon footprint of seawater desalination plants that use reverse osmosis membranes by introducing on-site renewable energy sources. By using new-generation membranes with a low energy consumption and considering wind and photovoltaic energy sources, it is possible to greatly reduce the carbon footprint of reverse osmosis plants. The objective of this study was to add a renewable energy supply to a desalination plant that uses reverse osmosis technology. During the development of this research study, photovoltaic energy was discarded as a possible source of renewable energy due to the wind conditions in the area in which the reverse osmosis plant was located; hence, the installation of a wind turbine was considered to be the best option. As it was a large-capacity reverse osmosis plant, we decided to divide the entire desalination process into several stages for explanation purposes. The desalination process of the facility consists of several phases: First, the seawater capture process was performed by the intake tower. This water was then transported and stored, before going through a physical and chemical pre-treatment process, whereby the highest possible percentage of impurities and organic material was eliminated in order to prevent the plugging of the reverse osmosis modules. After carrying out the appraisals and calculating the amount of energy that the plant consumed, we determined that 15% of the plant’s energy supply should be renewable, corresponding to 1194 MWh/year. As there was already a wind power installation in the area, we decided to use one of the wind turbines that had already been installed—specifically, an Ecotecnia turbine (20–150) that produced an energy of 1920 MWh /year. This meant that only a single wind turbine was required for this project.
Extracellular Vesicles Tropism: A Comparative Study between Passive Innate Tropism and the Active Engineered Targeting Capability of Lymphocyte-Derived EVs
Authors: Limongi Tania , Susa Francesca , Dumontel Bianca , Racca Luisa , Perrone Donnorso Michela , Debellis Doriana , Cauda Valentina
Published: November 2021

Cellular communications take place thanks to a well-connected network of chemical–physical signals, biomolecules, growth factors, and vesicular messengers that travel inside or between cells. A deep knowledge of the extracellular vesicle (EV) system allows for a better understanding of the whole series of phenomena responsible for cell proliferation and death. To this purpose, here, a thorough immuno-phenotypic characterization of B-cell EV membranes is presented. Furthermore, the cellular membrane of B lymphocytes, Burkitt lymphoma, and human myeloid leukemic cells were characterized through cytofluorimetry assays and fluorescent microscopy analysis. Through cytotoxicity and internalization tests, the tropism of B lymphocyte-derived EVs was investigated toward the parental cell line and two different cancer cell lines. In this study, an innate capability of passive targeting of the native EVs was distinguished from the active targeting capability of monoclonal antibody-engineered EVs, able to selectively drive the vesicles, enhancing their internalization into the target cancer cells. In particular, the specific targeting ability of anti-CD20 engineered EVs towards Daudi cells, highly expressing CD20 marker on their cell membrane, was proved, while almost no internalization events were observed in HL60 cells, since they did not express an appreciable amount of the CD20 marker on their plasma membranes.
Air Pollution Modelling by Machine Learning Methods
Authors: Vidnerová Petra , Neruda Roman
Published: November 2021

Precise environmental modelling of pollutants distributions represents a key factor for addresing the issue of urban air pollution. Nowadays, urban air pollution monitoring is primarily carried out by employing sparse networks of spatially distributed fixed stations. The work in this paper aims at improving the situation by utilizing machine learning models to process the outputs of multi-sensor devices that are small, cheap, albeit less reliable, thus a massive urban deployment of those devices is possible. The main contribution of the paper is the design of a mathematical model providing sensor fusion to extract the information and transform it into the desired pollutant concentrations. Multi-sensor outputs are used as input information for a particular machine learning model trained to produce the CO, NO2, and NOx concentration estimates. Several state-of-the-art machine learning methods, including original algorithms proposed by the authors, are utilized in this study: kernel methods, regularization networks, regularization networks with composite kernels, and deep neural networks. All methods are augmented with a proper hyper-parameter search to achieve the optimal performance for each model. All the methods considered achieved vital results, deep neural networks exhibited the best generalization ability, and regularization networks with product kernels achieved the best fitting of the training set.
Stroke Aetiology and Collateral Status in Acute Ischemic Stroke Patients Receiving Reperfusion Therapy—A Meta-Analysis
Authors: Sinha Akansha , Stanwell Peter , Beran Roy G. , Calic Zeljka , Killingsworth Murray C. , Bhaskar Sonu M. M.
Published: November 2021

Background: The interplay between collateral status and stroke aetiology may be crucial in the evaluation and management of acute ischemic stroke (AIS). Our understanding of this relationship and its level of association remains sub-optimal. This study sought to examine the association of pre-intervention collateral status with stroke aetiology, specifically large artery atherosclerosis (LAA) and cardio-embolism (CE), in AIS patients receiving reperfusion therapy, by performing a meta-analysis. Methods: Relevant search terms were explored on Medline/PubMed, Embase and Cochrane databases. Studies were included using the following inclusion criteria: (a) patients aged 18 or above; (b) AIS patients; (c) patients receiving reperfusion therapy; (d) total cohort size of >20, and (e) qualitative or quantitative assessment of pre-intervention collateral status on imaging using a grading scale. Random-effects meta-analysis was performed to investigate the association of aetiology with pre-intervention collateral status, and forest plots of risk ratio (RR) were generated. Results: A meta-analysis was conducted on seven studies, with a cumulative cohort of 1235 patients, to assess the association of pre-intervention collateral status with stroke aetiology. Patients with LAA were associated significantly with an increased rate of good collaterals (RR 1.24; 95% CI 1.04–1.50; p = 0.020, z = 2.33). Contrarily, CE aetiology was associated significantly with a decreased rate of good collaterals (RR 0.83; 95% CI 0.71–0.98; p = 0.027, z = −2.213). Conclusions: This study demonstrates that, in AIS patients receiving reperfusion therapy, LAA and CE aetiologies are associated significantly with collateral status.
Diet Quality of Australian Children and Adolescents on Weekdays versus Weekend Days: A Secondary Analysis of the National Nutrition and Physical Activity Survey 2011–2012
Authors: Dutch Dimity C. , Golley Rebecca K. , Johnson Brittany J.
Published: November 2021

Daily routines may influence children and adolescents’ eating patterns, however the influence of days of the week on dietary intake has rarely been explored. This study aimed to examine discretionary choices intake in the context of diet quality on weekdays versus weekends. A secondary analysis was conducted using the Australian National Nutrition and Physical Activity Survey 2011–2012. Differences in discretionary choices intake and diet quality on weekdays versus weekends, were examined using ANCOVA analyses. Associations between child and parent-proxy characteristics and weekday/weekend discretionary choices intake were examined using multivariable regression models. Primary analyses included 2584 Australian 2–17-year-olds. There were small differences in discretionary choices intake and diet quality between weekdays and weekends in all age subgroups. Compared to weekdays, intakes on weekends were characterized by a higher intake of discretionary choices, and lower total Dietary Guidelines Index for Children and Adolescents (DGI-CA) scores across the age subgroups (all p < 0.01). Parent-proxy discretionary choices intake and child age were predictors of weekday and weekend discretionary choices intake. Parent-proxy obesity weight status compared with healthy weight status was a predictor of weekend intake, while parent-proxy education level was a predictor of weekday discretionary choices intake. Future intervention strategies should target discretionary choices intake on both weekdays and weekends.
Coping with Hypertension among Indigenous Peoples in Brazil and the Role of the Primary Care Nurse: A Critical Review from a Transcultural Perspective
Authors: Oliveira Mauricio Viana Gomes , Abreu Ângela Maria Mendes , Welch James R. , Coimbra Carlos E. A.
Published: November 2021

Our objective is to critically review the literature addressing the strategic role of nurses in the daily primary care of arterial hypertension in Indigenous communities in Brazil. We selected studies based on an initial keyword search of major bibliographic indexing databases for the years 2000 to 2020 and manual search. Further selection was based on topical, methodological, and thematic relevance, as well as evaluation of scholarship quality and pertinence to our chosen narrative. The literature demonstrates Indigenous peoples do not receive health services that measure up to national standards in large part due to a marked lack of academic and employer preparation for nurses operating in transcultural settings. Inequities were apparent in recurrent reports of victim-blaming, deficient clinical communication with patients, clinical malpractice, devaluation of hypertension as a problem for Indigenous peoples, insufficient intercultural training for nurses, and discrimination against Indigenous students in nursing education programs. This systemic problem needs to be addressed by universities and the Indigenous Health Care Subsystem in Brazil.
Design, Synthesis, In Vitro Anticancer Evaluation and Molecular Modelling Studies of 3,4,5-Trimethoxyphenyl-Based Derivatives as Dual EGFR/HDAC Hybrid Inhibitors
Authors: Ibrahim Tarek S. , Malebari Azizah M. , Mohamed Mamdouh F. A.
Published: November 2021

Recently, combining histone deacetylase (HDAC) inhibitors with chemotherapeutic drugs or agents, in particular epidermal growth factor receptor (EGFR) inhibitors, is considered to be one of the most encouraging strategy to enhance the efficacy of the antineoplastic agents and decrease or avoid drug resistance. Therefore, in this work, based on introducing 3,4,5-trimethoxy phenyl group as a part of the CAP moiety, in addition to incorporating 4–6 aliphatic carbons linker and using COOH or hydroxamic acid as ZBG, 12 novel EGFR/HDAC hybrid inhibitors 2a–c, 3a–c, 4a–c and 5a–c were designed, constructed, and evaluated for their anticancer activities against 4 cancer cell lines (HepG2, MCF-7, HCT116 and A549). Among all, hybrids with hydroxamic acid 4a–c and 5a, exhibited the highest inhibition against all cancer cell lines with IC50 ranging from 0.536 to 4.892 μM compared to Vorinostat (SAHA) with IC50 ranging from 2.43 to 3.63 μM and Gefitinib with IC50 ranging from 1.439 to 3.366 μM. Mechanistically, the most potent hybrids 4a–c and 5a were further tested for their EGFR and HDACs inhibitory activities. The findings disclosed that hybrid 4b displayed IC50 = 0.063 µM on the target EGFR enzyme which is slightly less potent than the standard Staurosporine (IC50 = 0.044 µM). Furthermore, hybrid 4b showed less HDAC inhibitory activity IC50 against HDAC1 (0.148), 2 (0.168), 4 (5.852), 6 (0.06) and 8 (2.257) than SAHA. In addition, the investigation of apoptotic action of the most potent hybrid 4b showed a significant increase in Bax level up to 3.75-folds, with down-regulation in Bcl2 to 0.42-fold, compared to the control. Furthermore, hybrid 4b displayed an increase in the levels of Caspases 3 and 8 by 5.1 and 3.15 folds, respectively. Additionally, the cell cycle analysis of hybrid 4b revealed that it showed programmed cell death and cell cycle arrest at G1/S phase. Moreover, all these outcomes together with the molecular docking study recommended the rationalized target hybrids 4a–c and 5a, particularly 4b, may be considered to be promising lead candidates for discovery of novel anticancer agents via dual inhibition of both EGFR/HDAC enzymes.
Polyelectrolyte-Coated Mesoporous Bioactive Glasses via Layer-by-Layer Deposition for Sustained Co-Delivery of Therapeutic Ions and Drugs
Authors: Pontremoli Carlotta , Pagani Mattia , Maddalena Lorenza , Carosio Federico , Vitale-Brovarone Chiara , Fiorilli Sonia
Published: November 2021

In the field of bone regeneration, considerable attention has been addressed towards the use of mesoporous bioactive glasses (MBGs), as multifunctional therapeutic platforms for advanced medical devices. In fact, their extremely high exposed surface area and pore volume allow to load and the release of several drugs, while their framework can be enriched with specific therapeutic ions allowing to boost the tissue regeneration. However, due to the open and easily accessible mesopore structure of MBG, the release of the incorporated therapeutic molecules shows an initial burst effect leading to unsuitable release kinetics. Hence, a still open challenge in the design of drug delivery systems based on MBGs is the control of their release behavior. In this work, Layer-by-layer (LbL) deposition of polyelectrolyte multi-layers was exploited as a powerful and versatile technique for coating the surface of Cu-substituted MBG nanoparticles with innovative multifunctional drug delivery systems for co-releasing of therapeutic copper ions (exerting pro-angiogenic and anti-bacterial effects) and an anti-inflammatory drug (ibuprofen). Two different routes were investigated: in the first strategy, chitosan and alginate were assembled by forming the multi-layered surface, and, successively, ibuprofen was loaded by incipient wetness impregnation, while in the second approach, alginate was replaced by ibuprofen, introduced as polyelectrolyte layer. Zeta-potential, TGA and FT-IR spectroscopy were measured after the addition of each polyelectrolyte layer, confirming the occurrence of the stepwise deposition. In addition, the in vitro bioactivity and the ability to modulate the release of the cargo were evaluated. The polyelectrolyte coated-MBGs were proved to retain the peculiar ability to induce hydroxyapatite formation after 7 days of soaking in Simulated Body Fluid. Both copper ions and ibuprofen were co-released over time, showing a sustained release profile up to 14 days and 24 h, respectively, with a significantly lower burst release compared to the bare MBG particles.
Osteoinductive Moldable and Curable Bone Substitutes Based on Collagen, BMP-2 and Highly Porous Polylactide Granules, or a Mix of HAP/β-TCP
Authors: Vasilyev Andrey Vyacheslavovich , Kuznetsova Valeriya Sergeevna , Bukharova Tatyana Borisovna , Osidak Egor Olegovich , Grigoriev Timofei Evgenevich , Zagoskin Yuriy Dmitrievich , Nedorubova Irina Alekseevna , Domogatsky Sergey Petrovich , Babichenko Igor Ivanovich , Zorina Oksana Aleksandrovna , Kutsev Sergey Ivanovich , Chvalun Sergei Nicolaevich , Kulakov Anatoly Alekseevich , Losev Fedor Fedorovich , Goldshtein Dmitry Vadimovich
Published: November 2021

In dentistry, maxillofacial surgery, traumatology, and orthopedics, there is a need to use osteoplastic materials that have not only osteoinductive and osteoconductive properties but are also convenient for use. In the study, compositions based on collagen hydrogel were developed. Polylactide granules (PLA) or a traditional bone graft, a mixture of hydroxyapatite and β-tricalcium phosphate (HAP/β-TCP), were used for gel filling to improve mechanical osteoconductive properties of compositions. The mechanical tests showed that collagen hydrogels filled with 12 wt% highly porous PLA granules (elastic modulus 373 ± 55 kPa) or 35 wt% HAP/β-TCP granules (elastic modulus 451 ± 32 kPa) had optimal manipulative properties. All composite components were cytocompatible. The cell’s viability was above 90%, and the components’ structure facilitated the cell’s surface adhesion. The bone morphogenetic protein-2 (BMP-2) provided osteoinductive composition properties. It was impregnated directly into the collagen hydrogel with the addition of fibronectin or inside porous PLA granules. The implantation of a collagen hydrogel with BMP-2 and PLA granules into a critical-size calvarial defect in rats led to the formation of the most significant volume of bone tissue: 61 ± 15%. It was almost 2.5 times more than in the groups where a collagen-fibronectin hydrogel with a mixture of HAP/β-TCP (25 ± 7%) or a fibronectin-free composition with porous PLA granules impregnated with BMP-2 (23 ± 8%) were used. Subcutaneous implantation of the compositions also showed their high biocompatibility and osteogenic potential in the absence of a bone environment. Thus, the collagen-fibronectin hydrogel with BMP-2 and PLA granules has optimal biocompatibility, osteogenic, and manipulative properties.
Crown Ether-Immobilized Cellulose Acetate Membranes for the Retention of Gd (III)
Authors: Serbanescu Oana Steluta , Pandele Andreea Madalina , Oprea Madalina , Semenescu Augustin , Thakur Vijay Kumar , Voicu Stefan Ioan
Published: November 2021

This study presents a new, revolutionary, and easy method of separating Gd (III). For this purpose, a cellulose acetate membrane surface was modified in three steps, as follows: firstly, with aminopropyl triethoxysylene; then with glutaraldehyde; and at the end, by immobilization of crown ethers. The obtained membranes were characterized by Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS), through which the synthesis of membranes with Gd (III) separation properties is demonstrated. In addition, for the Gd (III) separating process, a gadolinium nitrate solution, with applications of moderator poison in nuclear reactors, was used. The membranes retention performance has been demonstrated by inductively coupled plasma mass spectrometry (ICP-MS), showing a separation efficiency of up to 91%, compared with the initial feed solution.
In Situ Printing and Functionalization of Hybrid Polymer-Ceramic Composites Using a Commercial 3D Printer and Dielectrophoresis—A Novel Conceptual Design
Authors: Tselikos Georgios , Rasul Shahid , Groen Pim , Li Chunchun , Khaliq Jibran
Published: November 2021

Three-dimensional printing-based additive manufacturing has emerged as a new frontier in materials science, with applications in the production of functionalized polymeric-based hybrid composites for various applications. In this work, a novel conceptual design was conceived in which an AC electric field was integrated into a commercial 3D printer (-based fused filament fabrication (FFF) working principle) to in situ manufacture hybrid composites having aligned ceramic filler particles. For this work, the thermoplastic poly lactic acid (PLA) was used as a polymer matrix while 10 vol% KNLN (K0.485Na0.485Li0.03NbO3) ceramic particles were chosen as a filler material. The degree of alignment of the ceramic powders depended upon print speed, printing temperature and distance between electrodes. At 210 °C and a 1 kV/mm applied electric field, printed samples showed nearly complete alignment of ceramic particles in the PLA matrix. This research shows that incorporating electric field sources into 3D printing processes would result in in situ ceramic particle alignment while preserving the other benefits of 3D printing.
Low-Temperature Thermal Degradation of Disinfected COVID-19 Non-Woven Polypropylene—Based Isolation Gown Wastes into Carbonaceous Char
Authors: Harussani M. M. , Rashid Umer , Sapuan S. M. , Abdan Khalina
Published: November 2021

Yields of carbonaceous char with a high surface area were enhanced by decreasing the temperature to improve the conversion of hazardous plastic polypropylene (PP), the major component in abundantly used isolation gowns. This study applied pyrolysis with different low pyrolytic temperatures to convert disinfected PP-based isolation gown waste (PP-IG) into an optimised amount of char yields. A batch reactor with a horizontal furnace was used to mediate the thermal decomposition of PP-IG. Enhanced surface area and porosity value of PP-IG derived char were obtained via an optimised slow pyrolysis approach. The results showed that the amount of yielded char was inversely proportional to the temperature. This process relied heavily on the process parameters, especially pyrolytic temperature. Additionally, as the heating rate decreased, as well as longer isothermal residence time, the char yields were increased. Optimised temperature for maximum char yields was recorded. The enhanced SBET values for the char and its pore volume were collected, ~24 m2 g−1 and ~0.08 cm3 g−1, respectively. The char obtained at higher temperatures display higher volatilisation and carbonisation. These findings are beneficial for the utilisation of this pyrolysis model in plastic waste management and conversion of PP-IG waste into char for further activated carbon and fuel briquettes applications, with the enhanced char yields, amidst the COVID-19 pandemic.
Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine
Authors: Al-Mhyawi Saedah R. , Ahmed Riham K. , El Nashar Rasha M.
Published: November 2021

This work demonstrates a facile electropolymerization of a dl-methionine (dl-met) conducting polymeric film on a gold nanoparticle (AuNPs)-modified glassy carbon electrode (GCE). The resulting sensor was successfully applied for the sensitive detection of paroxetine·HCl (PRX), a selective serotonin (5-HT) reuptake inhibitor (SSRIs), in its pharmaceutical formulations. The sensor was characterized morphologically using scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX) and atomic force microscopy (AFM) and electrochemical techniques such as differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The proposed sensor, poly (dl-met)/AuNPs-GCE, exhibited a linear response range from 5 × 10−11 to 5 × 10−8 M and from 5 × 10−8 to 1 × 10−4 M using DPV with lowest limit of detection (LOD = 1 × 10−11 M) based on (S/N = 3). The poly (dl-met)/AuNPs-GCE sensor was successfully applied for PRX determination in three different pharmaceutical formulations with percent recoveries between 96.29% and 103.40% ± SD (±0.02 and ±0.58, respectively).