bluuebunny/crossref_metadata_2025 huggingface dataset:
Peut-on encore faire de l’histoire des entreprises ?
Authors: Le Roux Muriel , Michel Alain P. , Nougaret Roger
Published: December 2023

Les auteurs s’interrogent sur les conditions actuelles de production de l’histoire d’entreprise ou business history à la fois sous l’angle des problématiques abordées et sous celui de l’accès aux sources. Après une période d’expansion de la discipline en France dans les années 1950-1960, est venue une période de consolidation jusqu’aux années 2000, notamment en raison d’une meilleure organisation des archives d’entreprise, de la possibilité d’aborder des périodes ou sujets sensibles, ou d’un besoin d’histoire exprimé par les salariés. Il semble aujourd’hui plus difficile de pratiquer l’histoire des entreprises, car l’accès aux archives est moins aisé qu’il ne l’a été : prévalence de la communication, judiciarisation du monde des affaires, changements de structures affectant les entreprises, difficultés touchant le monde de la recherche, notamment en histoire économique, peuvent expliquer certaines évolutions. Les voies d’amélioration pourraient consister à revisiter la notion de patrimoine, faire un usage bien pensé de la demande de commémoration ou créer un nouveau contrat entre les entreprises et la recherche académique par le biais de l’histoire appliquée ou

public history.
Inhibition of Amino Acids Influx into Proximal Tubular Cells Improves Lysosome Function in Diabetes
Authors: Kano Yuzuki , Yamaguchi Satoshi , Mise Koki , Kawakita Chieko , Onishi Yasuhiro , Kurooka Naoko , Sugawara Ryosuke , Albuayjan Haya Hamed Hassan , Nakatsuka Atsuko , Eguchi Jun , Wada Jun
Published: December 2023

Key Points

Collectrin serves as a chaperone for the trafficking of neutral amino acid (AA) transporters in the apical membranes of proximal tubular cells (PTCs).

Cltrn knockout reduced AAs influx into PTCs, inactivated mTOR, activated transcription factor EB, improved lysosome function, and ameliorated vacuolar formation of PTCs in diabetic mice treated with streptozotocin and high-fat diet.

The inhibition of neutral AA transporter, such as B0AT1 (SLC6A19), and transcription factor EB activator is a new therapeutic strategy against diabetic kidney disease.

Background

Inhibition of glucose influx into proximal tubular cells (PTCs) by sodium–glucose cotransporter 2 inhibitors revealed prominent therapeutic effects on diabetic kidney disease. Collectrin (CLTRN) serves as a chaperone for the trafficking of neutral amino acid (AA) transporters in the apical membranes of PTCs. We investigated the beneficial effects of reduced influx of AAs into PTCs in diabetes and obesity model of Cltrn−/y mice.

Methods

Cltrn+/y and Cltrn−/y mice at age 5 weeks were assigned to standard diet and streptozotocin and high-fat diet (STZ-HFD)–treated groups.

Results

At age 22–23 weeks, body weight and HbA1c levels significantly increased in STZ-HFD-Cltrn+/y compared with standard diet-Cltrn+/y; however, they were not altered in STZ-HFD-Cltrn−/y compared with STZ-HFD-Cltrn+/y. At age 20 weeks, urinary albumin creatinine ratio was significantly reduced in STZ-HFD-Cltrn−/y compared with STZ-HFD-Cltrn+/y. Under the treatments with STZ and HFD, the Cltrn gene deficiency caused significant increase in urinary concentration of AAs such as Gln, His, Gly, Thr, Tyr, Val, Trp, Phe, Ile, Leu, and Pro. In PTCs in STZ-HFD-Cltrn+/y, the enlarged lysosomes with diameter of 10 μm or more were associated with reduced autolysosomes, and the formation of giant lysosomes was prominently suppressed in STZ-HFD-Cltrn−/y. Phospho-mTOR and inactive form of phospho-transcription factor EB were reduced in STZ-HFD-Cltrn−/y compared with STZ-HFD-Cltrn+/y.

Conclusions

The reduction of AAs influx into PTCs inactivated mTOR, activated transcription factor EB, improved lysosome function, and ameliorated vacuolar formation of PTCs in STZ-HFD-Cltrn−/y mice.
Masal Kahramanlarında Gerçeklik Algısı: Keloğlan Örneği
Authors: ORTA Nejla
Published: December 2023

Halk edebiyatının sözlü kültür ürünlerinden olan ve sonrasında yazıya geçirilen masal ve halk hikâyeleri gibi eserlerde gerçek ve gerçekçilik konusunun pek tartışılmadığı görülmektedir. Yapılan çalışmalar çoğunlukla semboller üzerinden ele alınmış ve psikanalitik açıdan değerlendirilmiştir. Özellikle modern edebiyatla birlikte masallar, gerçek ve gerçeklik kavramlarından uzak görülmüştür. Bu çalışma masallarda gerçekliğin nasıl olduğunu ve masal kahramanları üzerinden değerlendirilmesini amaçlamaktadır. Bu açıdan edebiyatta gerçek/gerçeklik/gerçekçilik konularına halk edebiyatı açısından bakmanın önemli olduğu düşünülmektedir. Edebiyatta gerçeklik kavramı farklı akımlarla farklı içerikler ve anlamlar kazansa da her dönemde ve her akımda farklı bir yapı kazanmıştır. Anlatılarda hayatın gerçekliği malzeme olarak kullanıldığı için ve özellikle masalın kahramanları masalda bir düzeni temsil ettiğinden dolayı o düzen içinde bulunduğu evreni, dünyayı, çevreyi algılama biçimi olarak bazı gerçekleri ve gerçeklik algısını da temsil etmektedir. Bu çalışmada Tahir Alangu’nun Keloğlan Masalları kitabındaki masallar öncelikli olmak üzere Anadolu insanın tipik özelliklerini taşıyan Keloğlan üzerinden kahramanın gerçeklik algısı analiz edilmektedir. Anlatım boyunca kahramanın yolculuğunda, gerçekliğin algısında bazı sorgulamalarla ve aşamalarla hatta olağanüstülüklerin de yardımıyla değişim yaşanır, yaşattırılır. Kahraman anlatı boyunca yaptığı sorgulamalar sayesinde gerçekliğe yeni boyut kazandırma fırsatı yakalar ve yolculuğunu tamamlayabilir. Keloğlan yolculuğunda üstünlüğü bu sorgulamalar sayesinde elde etmektedir. Kahramanın gerçeklik algısı, bireysel ve ortak tezahürlerle gerçekleri düşündürür, sorgulatır, yansıtır.
Rancang Bangun Alat Pengecat Dinding Semi Otomatis Berbasis Mikrokotrolel ATMega8535
Authors: Zaira Jupri Yanda
Published: December 2023

Proses pengecatan menjadi suatu kebutuhan untuk memperindah sebuah ruangan, dimana alat pengecat dinding otomatis dapat dijadikan solusi untuk meringankan pekerjaan manusia yaitu dapat membantu tugas rutinitas dalam proses pengecatan dinding  pada sebuah ruangan. Sistem yang digunakan pada rancang bangun alat pengecat dinding otomatis adalah menggunakan sistem kontrol mikrokontroler ATMega8535. Pengujian dilakukan dengan cara membuat settingan awal pada alat pengecatan sudah ditentukan, setelah itu tombol kontroler di aktifkan, dan selanjutnya alat akan langsung mengecat dinding secara semi otomatis, dimana pergerakan lengan alat menggunakan motor DC power window, dan kuas cat  menggunakan roler yang biasa dipakai untuk mengecat dinding pada suatu ruangan. Pergerakan rancang bangun alat pengecat dinding ini dilakukan secara otomatis, dimana perintah dari push button akan diproses di mikrokontroler yaitu ATMega8535 sebelum diteruskan ke aktuator yaitu motor DC yang diatur oleh driver motor. Hasil dari penelitian ini adalah Alat pengecat dinding ini mempunyai jangkauan pengecatan 2 m x 2 m dengan waktu 27,3 menit, dan untuk mendapatkan hasil merata harus dilakukan sebanyak 3 kali pengulangan. Kapasitas maksimum motor yang dibutuhkan untuk mengoperasikan alat pengecat dinding untuk motor power window maksimum sebesar 18,13 VA, dan untuk motor DC maksimum sebesar 18,32 VA.
Peningkatan Gain Antena Mikrostrip Patch Rectangular dengan Metode Element Parasitic Pada Frekuensi 2.1 GHz
Authors: Indani Wira , Sembiring Jhones Rona
Published: December 2023

Perkembangan dunia telekomunikasi nirkabel cukup pesat, hal ini dikarenakan mobilitas orang yang semakin hari semakin cepat menuntut untuk bergerak dan bergerak selalu, serta ketergantungan terhadap media komunikasi cukup tinggi. Salah satu perangkat yang sangat berpengaruh dalam media nirkabel adalah antenna. Dimana pada paper ini akan membahas perancangan antena mikrostrip agar dapat meningkatkan gain menggunakan metode elemen parasitic dan teknik iterasi posisi slot dengan rectangular slot untuk meningkatkan nilai return loss pada antena. Untuk jenis substrat yang digunakan adalah FR-4 Epoxy dengan h = 1,6 mm   dan teknik pencatuan yang digunakan adalah microstrip line. Dari hasil penelitian diperoleh bahwa dengan cara menambahkan teknik parasitic pada antena mampu menghasilkan gain dua kali lebih besar dari keadaan tanpa elemen parasitic. Selain itu, saat keadaan ditambahkan teknik iterasi posisi slot mampu menghasilkan nilai return loss yang lebih baik dari keadaan optimasi patch. Sehingga didapatkan hasil paling optimal pada antena single band 2,1 GHz dengan return loss -13.20 dB VSWR 1.53 impedansi 50,44 Î© dan gain 4.79 dB.
Alat Pemeras Lendir (Depulper) dan Pengering Biji Kakao Berbasis Programmable Logic Controller (PLC)
Authors: Wahyuni Retno tri , Saputra Dodi , Susianti Elva , Amirul Amirul
Published: December 2023

The quality of dry cocoa beans is highly dependent on the drying process. The drying rate of cocoa beans needs to be regulated so that the quality of dry cocoa beans is maintained. The drying rate that is too fast causes the acetic acid to become trapped in the seeds, affecting the smell and taste. The slow drying rate causes the cocoa beans to rot or to sprout. The drying process of cocoa beans can be done conventionally using the sun's heat or using a drying machine. The use of a drying machine allows drying at any time without being affected by the weather. A cocoa bean press and drying machine is a device designed from a mechanical and electronic perspective to properly dry the cocoa beans. The electronic system consists of input, controller and output parts. The input section consists of a start stop button and a thermocouple sensor, the controller is a programmable logic controller (PLC) while the output is a heating element (heater) and an AC motor. In this cocoa bean drying machine, the most suitable temperature for the proper drying rate is 500 Celsius. The drying cylinder is rotated using an AC motor so that heat energy can be distributed evenly. The test results show that the drying machine can control a stable cylinder temperature around 500 Celsius and can dry the cocoa beans in 3.5 to 5 hours depending on the weight of the beans being dried and their water content.
The Immanence of Abysmal Seduction in the Art of Acting
Authors:   Ovidius University of Constanta, Faculty of Arts, LUMANARE Iulia
Published: December 2023

The study makes a descent into the abysmal psychology of the creator, seeking to reveal the drive that makes the act of creation necessary: ​​the need to seduce. In the attempt to rehabilitate seduction and the essential role it has in the entire creative process, up to the meeting with the viewer - the ultimate witness and subject of seduction -, the study explores the psychological, philosophical, and professional dimensions of the concept of seduction, moving away from its immediate and trivial meanings. The intrinsic purpose of the approach is to restore the role of being a creator for the actor and to seduce him into becoming a conscious one, thus abandoning the irresponsible condition of the marionette. In an attempt to restore seduction’s numinosity, the study appeals to the great seducers of philosophy, psychoanalysis, and literature – Kirkegaard, Kant, Jung, Liiceanu, and Pessoa - supporting its arguments on their considerations, to reveal the impregnability of the link between seduction and creation.
Race Preparation: A Dialogue with the Past and the Future of Theater Director Pedagogy
Authors:   Faculty of Theatre and Film, University of Babeș-Bolyai, Cluj-Napoca, GLIGAN Mihai
Published: December 2023

The act of pedagogy, no matter how much it is theorized in scientific articles, is actually situated under the violent incidence of the human present, more precisely the contextual point at which an 18-year-old student sits in front of the teacher and wishes to be educated based on their extremely contemporary cultural references. Defining and framing concepts in an heuristic manner are on fertile ground when the object of the study is documented and summarized in the theoretical testimony of a teacher-researcher. However, the practical aspects of the pedagogical process are, in fact, the ones eloquent for an inherited-like understanding. The human aspect of pedagogy, the inspiration, and the active presence of the educator are the only factors that can transform sterile theory into living substance. Just as theater has abandoned its text-centric heritage, migrating towards a performative zone, some educators have chosen to make their lives the legacy they left behind, not the written memories.
The Nature of the „BEAST”
Authors:   George Enescu National University of Arts, Ion Creangă Theatre Bucharest, COVEȘANU Petre-Gabriel
Published: December 2023

Pre-adolescent kids love stories and do not accept deviations or interruptions in the narrative line. They are connected to "life" and immediately condemn the lack of sincerity. The very young audience is different from an adult or teenage audience. It must be understood and educated. "Children are the future" is not a cliché but a reality. If the psychological mechanisms and springs that make them work are analysed and used intelligently in a show with a complex universe, theatre can create a leap in consciousness for new generations. Building techniques must be developed and improved in such a way that the performing arts regain their vital role in the rebirth of a nation.
Hetero-assembly design of 2D oxide nanosheets for tailored thermal shielding materials
Authors: Tsunematsu Hirofumi , Nishibashi Keita , Yamamoto Eisuke , Kobayashi Makoto , Yoshida Tomohiro , Osada Minoru
Published: December 2023

We present a new approach for designing thermal shielding materials using two-dimensional oxide nanosheets. Our approach uses hetero-assembly design [(Ti0.87O2)
m
(Cs2.7W11O35−d
)20 (m = 0, 5, 10)] by overlaying high refractive index (n) Ti0.87O2 nanosheets with transparent conducting Cs2.7W11O35−d
nanosheets. Through proper design of the thickness of high-n Ti0.87O2 layers, we achieved the optimum thermal shielding properties with a high NIR reflectance (>46%), a high visible transparency (>76%) and a neutral color in an ultrathin form (<60 nm). Our nanosheet approach is of technological importance for exploring new thermal shielding materials.
Climate Change and Human Rights: A Brief Review on the Constitutional Guarantee of Climate Human Rights
Authors:   Korean Constitutional Law Asscciation, Lee Jae Hee
Published: December 2023

Climate change is distinct from natural disasters. It is caused by man-made carbon emissions, and at the same time it can be mitigated by man-made efforts to reduce greenhouse gases. Therefore, the damage caused by climate change should not be treated like a natural disaster. Governments and the international community are held accountable for the damage caused by climate change. Also, climate change is not just an environmental problem. Climate change affects essential aspects of individuals' lives. Individual rights can be immediately jeopardized by climate disasters and threatened in the long term by the cumulative effects of climate change. And these risks of climate change are more than temporary, they are increasing and ever-present risks. This is why the responsibility of the state to protect individuals from the dangers of climate change arises. To prevent the harms of climate change, we need to start the discussion from the perspective of ensuring climate rights. I would like to explain that states have an obligation to prevent climate change and to maintain a level of human rights. In order for climate rights to be guaranteed through domestic judicial procedures, the possibility of guaranteeing them through constitutional litigation should be examined. The content of climate rights is not directly stipulated in the Constitution. However, I argue that by interpreting the Korean Constitution, we can derive from the Constitution the obligations of the state to guarantee climate human rights, and then examine whether the state has properly fulfilled its obligations to guarantee climate rights. The climate human rights that are required to be protected from the risks of climate change can be specifically described as the fundamental rights under our Constitution: the right to life, the right to physical and mental health, the dignity and worth of the human person, the right to freedom of action in general, and the right to the environment. In addition, through the interpretation of the content of the fundamental rights guaranteed by the Constitution, the content and subject of the rights to be protected by the climate right should be expanded. Therefore, it is necessary to encompass the contents of climate human rights as a new human right requested to respond to the current climate crisis situation.
Germany's Online Search and IT fundamental rights
Authors:   Korean Constitutional Law Asscciation, Park Hee-Young , Hong Sunki
Published: December 2023

The Telegram ‘N’ Room incident that shook the Republic of Korea in March 2020 raised the need for a further investigation into digital sexual exploitation. In other words, existing methods have limitations in investigation due to the changing digital environment and the development of encryption technology, and some inevitable measures were needed to ensure national security and maintain order for serious crimes that violate people's lives and freedoms. Major countries have already legislated a system called online search in preparation for security crimes such as terrorism as well as transnational cyber crimes such as digital sex crimes. Considering the reality of cybercrime, which is difficult to investigate only with existing methods such as seizure and search, it is time to actively consider the introduction of online search. However, these actions relate to fundamental rights under the Constitution. Therefore, the authorization regulations that legislate online search must meet constitutional requirements to justify the restriction of basic rights. In this regard, in the case of Germany, an online search system was introduced in 2016, and the constitutional judgment of the Federal Constitutional Court is also published. Based on the Federal Constitutional Court's ruling, Germany judged the online search itself to be constitutional, but the Federal Criminal Investigation Agency Act and the Criminal Procedure Act were revised to supplement the contents of online search and crypto communication monitoring. Through these discussions in Germany, we will be able to gauge our direction on the introduction of online search.
A PRE EXPERIMENTAL STUDY TO ASSESS THE EFFECT OF VIDEO ASSISTED TEACHING ON KNOWLEDGE REGARDING CHILDREN WITH DYSLEXIAAND ITS MANAGEMENT AMONG PRIMARY SCHOOL TEACHERS IN SELECTED SCHOOL, BHOPAL, M.P.
Authors: Maxwell Lal Monica , Lawrence Sunita
Published: December 2023

Introduction Dyslexia is the specic developmental disorder in children may cause impairment in academic functioning at school, especially
when language is affected or impairment in the daily activities. Method An evaluative approach is used to observe the effectiveness of teaching
methodology regarding children with dyslexia and its management among 60 primary school teachers of Holy family school (Shanti Nagar).
Convenience sampling was used.The research design selected for this study was one group pre –test post- test research design. Result The
reliability of the structured knowledge questionnaire was calculated by split half method and found to be r=.89which is indictedthat tool is highly
reliable.The data collected was analysed by using descriptive and inferential statistics. The calculated “t” value of 14.35 at P<0.05 level shows that
there is a signicant difference in knowledge level of primary school teachers. Conclusion The nding of the study conclude that Video Assisted
Teaching on children with dyslexia and its management was effective in enhancing knowledge level of primary school teachers.
ASSOCIATION OF RENAL PROFILE PARAMETERS WITH TSH IN HYPOTHYROID PATIENTS
Authors: Jain Ankita , Kapoor Sangeeta , Kumar Ajay
Published: December 2023

Background: Thyroid stimulating hormone (TSH) have a great impact on the kidneys as they monitor growth, development as well as
hemodynamics by modulating the glomerular ltration rate and renal plasma ow. Objective: To correlate the renal prole parameters (serum urea,
uric acid, creatinine, calcium, phosphorus, alkaline phosphatase, sodium, potassium, chloride and eGFR) with serum TSH in hypothyroid patients.
Material and Methods: Automated methods were used for the evaluation of renal prole parameters, Modication of diet in renal disease
(MDRD) formula for eGFR and ELFA method for serum TSH in the sample size of 150 hypothyroid patients. Result: TSH levels were found to
have signicant correlation with several renal prole parameters including serum urea, creatinine, uric acid, calcium, phosphorus, sodium and
eGFR. Conclusion: Renal prole test should be monitored in the patients of hypothyroidism for the proper diagnosis as well as to monitor the
severity of the underlying cause.
SPECTRUM OF GASTROINTESTINAL CANCERS IN SOUTH INDIA: ENDOSCOPIC AND HISTOPATHOLOGICAL CHARACTERISTICS- A SINGLE CENTRE CROSS SECTIONAL STUDY
Authors: Verma Somnath , Sundar Bhavishya , Padmanabhan P , Dinakaran N
Published: December 2023

Objective: This study aims to explore endoscopic and histopathological ndings of gastrointestinal cancers in South India, emphasizing different
subtypes and clinicopathological features. It also investigates underlying mechanisms, contributing factors, and risk factors specic to the South
Indian population. The role of endoscopy in the early detection of gastrointestinal cancer is emphasized. This retrospective Materials & Methods:
study analyzed endoscopic biopsy data of 100 patients at the Department of Gastroenterology, Meenakshi Medical College and Research Institute,
Kanchipuram. Inclusion criteria covered suspected gastrointestinal cancer cases that underwent endoscopic procedures and biopsies. Biopsy
specimens were processed, and tumors were classied based on WHO's gastrointestinal tumour histological classication. Of the 100 Results:
cases, 27% were esophageal, 52% gastric, 3% duodenal, and 18% colorectal cancers. Esophageal cancer was predominantly squamous cell
carcinoma (77%) located in the middle third of the esophagus (59%). Gastric cancer showed male predominance (M: F = 6.4:1) with advanced
adenocarcinoma in the pylorus (62%), cardia, and fundus (33% each). Colorectal cancer primarily occurred in the rectosigmoid (66%), followed by
the sigmoid colon and ascending colon (17% each). This study highlights the distribution Conclusion: of gastrointestinal cancers in South India,
with adenocarcinoma being the most prevalent histopathological subtype. Endoscopic ndings were consistent with histopathological results,
reafrming the value of biopsy as a diagnostic complement to endoscopy. Further studies, including multicenter research, are essential to gain
comprehensive insights into gastrointestinal cancers in rural regions of South India. Understanding clinicopathological patterns will aid in early
detection and treatment, enhancing patient management and outcomes.
RATIONALITY OF CEREBROSPINAL FLUID STUDY IN SIMPLE FEBRILE SEIZURE IN AGE GROUP 6 MONTHS TO 18 MONTHS
Authors: Kotokey Hangsha , Rahman Mahibur , Barman Diganta , Deka Anupama
Published: December 2023

Background: Febrile seizures are the most commonly encountered emergency visits in the Pediatric Department and it represents the most
common form of childhood seizures, affecting approximately 3-8% cases between 6 months to 60 months of age with peak incidence showing
between 12 to 18 months. Aim: To determine the incidence of acute bacterial meningitis in children between 6-18 months of age presenting with
rst episode of simple febrile seizure and nd out the rationality of performing routine lumbar puncture in these cases. Materials and Methods: It
was a hospital based prospective study where 81 cases presenting with rst episode of simple febrile seizure between age group 6-18 months in
Pediatric Department were subjected to CSF analysis by performing lumbar puncture. Meningitis was dened on cerebrospinal uid analysis
having more than 100 white blood cells, raised CSF protein more than 100 mg/dl and decreased CSF glucose less than 2/3rd of blood glucose.
Blood sugar was recorded prior to performing lumbar puncture to compare with CSF glucose to interpret the results. Results:Among the 81 cases
enrolled, 7.4% (6 cases) were diagnosed as acute bacterial meningitis based on CSF ndings. 66.7% (4 cases) were females and rest 33.3% (2
cases) were males. 50% (3 cases) of the diagnosed cases of meningitis had no symptoms of refusal to feed, 83.3% (5 cases) had no bulged anterior
fontanelle on examination and 100% (6 cases) had no altered sensorium. This study showed a positive co-relation between no symptoms and
meningitis in simple febrile seizure (p value <0.0001). Conclusion: This study provides evidence that febrile seizure can be the sole manifestation
of acute bacterial meningitis in children less than 18 months in whom clinical signs could be subtle or even absent. Therefore, routine lumbar
puncture should be done in children presenting with rst episode of simple febrile seizure for early diagnosis and treatment
CASE SERIES STUDY OF SEVERE PRE-ECLAMPSIA/ECLAMPSIA PATIENTS WITH PERINATAL & MATERNAL MORTALITY DURING THIRD WAVE OF COVID-19 PANDEMIC IN A TERTIARY INSTITUTE
Authors: Pratima Devi Khumanthem , Longjam Nirmala , Angomchanu Ranjeeta , Kongkham Tarunibala , Salam Sushila , Singh M Rameswar
Published: December 2023

Background: Preeclampsia is a multi-organ disease characterized by the development of hypertension and proteinuria. The World Health
Organization estimates that preeclampsia is directly responsible for 10 % of direct maternal mortality in Asia and also leads to signicant neonatal
morbidity and mortality. Objective: To ascertain the link between severe pre-eclampsia/ eclampsia patients with perinatal and maternal deaths
during the 3rd wave of covid-19 pandemic Methodology: Retrospective Case series study from November 2021 to February 2022 at the
Department of Obstetrics and Gynaecology RIMS. Data were collected from 5 severe pre-eclampsia and 2 eclampsia patients admitted in
Obstetrics and Gynaecology Department, RIMS. Results: All the 7 patients had perinatal deaths and all (100%) were Unbooked. There were 5
cases of intrauterine deaths (71.43%) and 2 (28.57%) neonatal deaths (Preterm meconium and another vehicle delivery with eclampsia). HELLP
syndrome was developed in two cases and retinopathy in 3 cases. Prophylactic MgSo4 was given to all the cases but one maternal death was seen
due to massive cerebrovascular accident and eclampsia before reaching the emergency care. Conclusion: Regular antenatal testing with nonstress
tests at the time of diagnosis and repeating twice weekly for FGR or oligohydramnios with Umbilical artery Doppler ultrasound weekly if FGR
present and timely control of hypertension with medications with low dose aspirin starting between 12 and 16 weeks of gestation will help in
reducing both maternal and perinatal morbidity as well as mortality. Self-monitoring of blood pressure in this era of covid 19 pandemic may result
in earlier detection of pre-eclampsia
A RARE CASE REPORT OF PRIMARY LYMPH NODE GASTRINOMA.
Authors: Devadasan Gargi , Raju Prabhakaran , Chidam baranathan Sugumar , Lakshma namoorthy Naganath Babu Obla
Published: December 2023

Background: Gastrinoma, is a functioning Neuroendocrine tumor usually arising from gastrinoma triangle .(90%) with high metastatic potential
to liver and lymph node.lymph node primary is a rare clinical presentation.hereby presenting a rare case of primary lymph node gastrinoma.
Methodology: 26 year male diagnosed as a case of sporadic gastrinoma (2018) on basis of clinical,biochemical and imaging methods ,now
presented with metabolic alkalosis, seizures, severe epigastric pain, vomiting and seizure of 2month duration .Clinical examination was
unremarkable. localization studies revealed (68Ga DOTANOC scan) lesion of size 5*5cm in the gastrohepatic region.no lesion in gastrinoma
triangle. After optimization patient was taken for surgery. 6*5cm cystic lesion in hepatogastric region was resected . whipples procedure done
considering the occult nature of duodenal lesion even after duodenotomy and hyperechoic lesion in IOS in pancreas. Preoperatively patient
condition improved markedly and gastrin level reduced to 27pg/ml from 10000pg/ml. Histopathology reported as grade 1 neuroendocrine tumour
for the nodal tissue with no lesions in the pancreas or duodenum. Our case is a Results: primary lymph node gastrinoma as there is no lesion in the
gastrinoma triangle and rest of pancreas.prognosis of primary lymph node gastrinoma is not dened so far as like metastatic lymph node
gastrinoma.patient needs regular follow up to look for recurrence. Though lymph node metasta Conclusions: sis is common with gastrinoma
primary lymph node gastrinoma can be diagnosed after excluding the primary source.
OBTURATOR NERVE BLOCK FOR TRANSURETHRAL RESECTION OF BLADDER TUMOUR: A COMPARISON BETWEEN USG GUIDED TECHNIQUE AND USG WITH NERVE STIMULATION TECHNIQUE
Authors: T Haripriya , Deshpande Charulata , Lal Varun Archana
Published: December 2023

Background: Bladder tumours are the ninth most commonly diagnosed cancer worldwide. Transurethral resection of bladder tumours (TURBT)
plays a key role in treating bladder cancer, but one of the most serious complications is bladder perforation caused by obturator nerve reex.
Obturator nerve reex can be prevented by inducing obturator nerve block (ONB) after lumbar anesthesia. The present study was undertaken to
compare the effectiveness of ultrasound guided ONB versus ultrasound with peripheral nerve stimulation (PNS) techniques in TURBT. Method:A
total 60 patients of either sex posted for TURBTware recruited in the study and divided into two equal groups. Group-1 was given with ONB using
USG and group-2 was given with USG plus PNS technique. All patients were assessed for motor block success, block performance time and the
number of needle passes. Results: There was a signicantly higher number of needles passes in USG guided group (3.77±1.33) in comparison to
USG+PNS guided group (3.03±1.25), (p=0.032). The mean block performance time in USG guided group was 12.13±1.69 min, while in the USG
plus PNS guided group it was 13.70±1.37 min, showing a signicantly longer block performance time in USG+PNS guided group, (p=0.001). Till
rst 10 minutes the block grading was comparable between two groups (p>0.05) but from 20 min onwards till end of 120 min block grading was
signicantly higher in USG+PNS guided group in comparison to USG guided group, (p<0.05). Conclusion: Thus, we conclude that US guided
obturator nerve blocks with PNS technique is more efcient that using USG alone.
PREVALENCE OF EXTRA-ARTICULAR MANIFESTATIONS IN ADULT RHEUMATOID ARTHRITIS PATIENTS AND CORRELATION WITH DISEASE ACTIVITY AND DURATION.
Authors: Kath Senjele , M. Kuotsu Medo , Konyak Nyamnyei , Kulnu Avono Dominica , L Joshua , Santa Naorem
Published: December 2023

Background: Rheumatoid arthritis (RA) is a chronic, inammatory, systemic, autoimmune disease involving the peripheral joints in a symmetric
distribution. The extra-articular manifestations of Rheumatoid arthritis have a major role as predictors of premature mortality in patients with the
disease. The objective of the study was to determine the prevalence of extra-articular manifestations in adult Rheumatoid arthritis patients and
correlation with disease activity and duration. A cross sectional study conduct Materials and Methods: ed among 80 patients diagnosed with
Rheumatoid arthritis, attending Rheumatology OPD, Medicine OPD and wards of Department of Medicine, Regional Institute of Medical
Sciences (RIMS), Imphal, Manipur over a period of 2 years from October 2019 to September 2021. The diagnosis of Rheumatoid arthritis was
made according to the 2010 ACR-EULAR (American college of Rheumatology/European League against Rheumatism) Classication Criteria
Result: The prevalence of extra-articular manifestation in Rheumatoid arthritis was found to be 78.7% in the study population. The mean age was
49.66±11.68 years and preponderance of female gender (76.2%) to rheumatoid arthritis was evident. The most common extra-articular
manifestation was haematological manifestations seen in 33.8% of the study subjects. 41.3% patients had existing disease duration between one
year to ve years. The cases with high positive rheumatoid factor had 7 times more odds of developing extra-articular manifestations. Conclusion:
The study concluded that increased Disease activity score 28 (DAS28), duration of disease and high positive rheumatoid factor levels were
signicant predictors of extra-articular manifestations in adult patients of Rheumatoid arthritis.
ANESTHETIC MANAGEMENT IN A CASE OF ANTIPHOSPHOLIPID ANTIBODY SYNDROME
Authors: Sharma Deeksha , V Harlapur Anagha
Published: December 2023

Antiphospholipid syndrome (APS) is an autoimmune disease associated with increased risk of thrombosis due to the presence of procoagulatory
antibodies. Anesthetic management in a patient with APS may pose a challenge, especially during pregnancy and delivery. We hereby present a
case of successful management of emergency cesarean delivery in a patient with APS.
SCREENING OF SMELLAND TASTE SENSATION IN MILD TO MODERATE COVID 19 CASES: AN EMERGING SYMPTOM?: A PROSPECTIVE STUDY
Authors: Chaurpagar Khandare Rajeshree , Pawde Apurva , Muneer Mohammed Badarul
Published: December 2023

Background: WHO declared COVID 19 viral infection as PHEIC followed by pandemic. And it was a catastrophe to world economy. Anosmia
and dysgeusia were of the symptoms of discussion. Nations were earnestly looking for Cost effective management. Objective: To describe
correlation between clinical , epidemiological , laboratorial and radiological , nding of COVID 19 infected patient and their relation to anosmia
and dysgeusia Methods: Prospective study carried out in tertiary care hospital, AKOLAfrom a period of November 2020 to Feb. 2021, Conducted
on Patient with RTPCR positive COVID 19 admitted to ward are interviewed using questionnaire in Google form and data collected from medical
records after obtaining verbal informed consent. Questionnaires are developed by a team of qualied doctors. All data analyses are completed with
SPSS version 25. Results: 52% of patients were having either anosmia or dysgeusia, in which 65 % patient had developed these symptoms before
diagnosis COVID 19. These symptoms were more signicant in age group of 40 to 60 (p <0.05) Conclusion: Use of anosmia or dysgeusia as early
screening tool of COVI D- 19 is add-on for diagnosis and abate morbidity and mortality. Neurotropic virus has less impact on pulmonary function
because majority of anosmia and dysgeusia patient had mild or absent HRCT thorax changes. There was no relation between Anosmia and any
other nasal symptoms.
A zoning of the Metropolitan City of Naples and analysis of land values
Authors: Cupo Paolo , Dell'Isola Erasmo
Published: December 2023

This paper presents the results of a zoning study involving the metropolitan city of Naples, for the purpose of identifying the areas within which to perform a comparable search by applying the synthetic-comparative market value procedure of appraisal. Moreover, an analysis was carried out of the values of agricultural land reported by two official sources, i.e. average land values (VFM) and average agricultural values (VAM), and by an unofficial source, i.e. the values of the Observatory of Agricultural Values (VAO). The results show that for some area/crop quality combinations, the values recorded can provide a significant indication of the agricultural value to be estimated. Vice versa, for estimating the agricultural value of land cultivated with the most profitable crops, the official values showed to be unreliable, meaning that the appraisal requires an accurate field survey. As for the differences between the different homogeneous areas, VAO prove to be more reliable, while VAM are the least significant values.
All Hands Needed at the Pump to Extinguish Climate Change Fires & Expedite Coveted Energy Transition Outcomes
Authors: Granger Dale
Published: December 2023

On the surface a seemingly faster spinning world is at an inflection point, but understanding the subsurface holds the key to a successful energy transition, which brings geoscientists of all persuasions, including petroleum, into play to confront a challenging future that should be embraced, not feared.
Partisipasi Perguruan Tinggi Pada Kegiatan Hari Jadi Kelurahan Gombengsari Kabupaten Banyuwangi
Authors: Gatut Rubiono  , Adi Mulyadi  , Edvin Cahyono
Published: December 2023

Community service is one of the dharma and obligations of college. One form of activity is participation in activities at the village/kelurahan level. The writing of this article aims to describe the participation of college in the anniversary activities of the Gombengsari village, Banyuwangi district. Participation is carried out according to the invitation of the organizing committee. Participation was carried out from elements of structural officials, the unit of Humas dan Penerimaan Mahasiswa Baru and university students. University have participated in enlivening and enlivening activities in the form of ceremonial events, exhibition and environmental dialogues.
A docência aplicada em práticas de blended learning sob a ótica da mediação da aprendizagem: Mecanismo de inovação e mudança da sala de aula tradicional
Authors: Braga Iago Mateus dos Santos , Nonato Gleides Ander
Published: December 2023

As práticas Blended Learning, conhecidas como B-Learning ou Ensino Híbrido, vêm sendo implementadas nas instituições de ensino brasileiras. Esse trabalho discute possibilidades de aplicação dessa metodologia e o papel do professor, enquanto mediador, na presença de novas tecnologias de informação e comunicação. Refletiu-se como se constitui a relação nas interações sociais e aprendizagem de conteúdos sob a ótica das teorias da mediação da aprendizagem acerca das contribuições de Vygotsky, Feuerstein e Tébar. Trata-se de pesquisa bibliográfica, de caráter exploratório e natureza qualitativa, que levantou os preceitos sobre essa metodologia e o entendimento de sua utilização. Concluiu-se que o aprendizado que proporciona é uma realidade e a personalização da aprendizagem proporciona experiência significativa. O B-Learning constitui mecanismo eficaz para o alcance desse objetivo, cuja utilização pode se dar mediante diversos modelos, viabilizando a experiência da aprendizagem mediada.
Tecnologia auxiliando na formação de professores indígenas em Manaus
Authors: Oliveira Pontes Joyce Karoline Pinto , Araujo Soares Artemis de
Published: December 2023

A formação de professores indígenas é uma demanda antiga no qual requer capacitação através da conclusão de um curso superior cujo objetivo é fortalecer a cultura, a escolarização de alunos indígenas, bem como manter as tradições, costumes a partir de uma educação comunitária e intercultural. Logo, este artigo tem como objetivo contextualizar práticas pedagógicas do Programa de Formação de Professores Indígenas (PROIND) da Universidade do Estado do Amazonas (UEA) mediados por tecnologia de Internet Protocol Television (IPTV) na cidade de Manaus.
Perspectivas dos docentes de Educação Infantil em torno do Ensino Remoto: Dificuldades e expectativas
Authors: Priscila Wunsch Luana , Dias de Lima Aline , da Silva Malta Leticia Maria , Ferreira Alves Felipe
Published: December 2023

O ano de 2020 trouxe consigo questões intensas da relação saúde e educação. Pela questão do isolamento social advindo da pandemia COVID-19, uma das mudanças mais bruscas deste cenário é a necessidade de relacionar-se de forma quase que exclusiva por meio das tecnologias. E para a educação, além disso estão sendo os debates sobre o ensino remoto e ensino híbrido. Perante essa realidade, este estudo tem como objetivo apresentar caminhos e possibilidades do ponto de vista formativo, para que os profissionais que atuam na Educação Infantil, reconhecidas suas particularidades, possam elaborar sentidos e significados positivos para o uso das tecnologias digitais como aliadas do processo de aprendizagem dos educandos dessa faixa etária. Para tanto, a pesquisa de cunho qualitativo e exploratório foi realizado em três fases (i) entrevista com professores da educação infantil, por meio de questionário (ii) revisão bibliográfica de literatura sobre as peculiaridades da educação infantil e sociedade (iii) análise dos dados obtidos no questionário. Ao refletir sobre estes dados, é imprescindível trazer a importância de uma nova estruturação da formação inicial dos professores, o que acaba por demandar novas promulgações de legislações baseadas nas novas competências exigidas no professor.
AIDP BEFORE AND AFTER COVID-19 IN ALGERIA: SHORT COHORT STUDY
Authors: T. Ait Mouheb  , L. Ait Mokhtar  , Z. Amine
Published: December 2023

Acute inflammatory demyelinating polyradiculoneuropathy is an immune-mediated polyneuropathy (AIDP) that manifests in the form of an acute, ascending, areflexic, progressive and symmetrical paralysis.
The primary infection usually from the respiratory or gastrointestinal tract and can be bacterial or viral, and during the pandemic SARS -COV2 and COVID-19 vaccine may also lead to it
Life-threatening complications can occur as a result of Acute inflammatory demyelinating polyradiculoneuropathy Syndrome, such as: Severe Autonomic Cardiovascular Dysfunction and respiratory distress.
We will report cases who were admitted to the ICU at Lamine Debaghine hospital between 2018 and 2023 presenting major complications and their evolution under ICU ward assistance.
CATEGORY: Resuscitation and Anesthesia, Emergency Medicine
KEYWORDS: Acute inflammatory demyelinating polyradiculoneuropathy syndrome, dysautonomia, ICU, AIDP, Guillain-Barre.
El inocente impacto ambiental del suero de la leche
Authors: Lizárraga-Chaidez Marianne , Mendoza-Sánchez Magdalena , Abadía- García Lucía , García-Pérez Javier
Published: December 2023

En la producción de lácteos, se genera una gran cantidad de suero de leche, un subproducto que ha sido tradicionalmente considerado como un residuo. Sin embargo, esta perspectiva está cambiando, ya que se está trabajando en la revalorización del suero de leche para reducir su impacto ambiental negativo. Tanto la industria como los hogares están buscando formas de reutilizar el suero de leche, incluyendo su uso en la alimentación humana y animal, así como en la producción de materiales biodegradables como bioplásticos y biocombustibles. Esta revisión tiene como objetivo explorar el impacto ambiental del suero de leche y las oportunidades de su reutilización, destacando su importancia en la transición hacia una economía circular y sostenible.
Current risks of ensuring the economic security of enterprises under the conditions of digitalization
Authors: Seleznova Halyna , Stepanenko Ruslan
Published: December 2023

Nowadays, digitalization has spread its influence on all spheres of society; digital technologies contribute to a new level of global development and are a practical trend. A vital issue in digitalization is ensuring economic security at all levels and creating conditions for entrepreneurial activity. At the same time, business risks in the conditions of digitalization are increasingly uncertain. Therefore, the detection and identification of risks in the process of business activity is one of the most important tasks for ensuring economic security. The purpose of the publication is to reveal and identify modern risks that affect the provision of economic security of enterprises in the conditions of digitalization. The article examines issues related to identifying threats and risks to the economic security of enterprises in the conditions of digitalization and globalization of the economy and their management. The essence of the concept of "economic security" is defined, the mechanism of ensuring the economic security of the enterprise is defined, and the analysis of the impact of digitalization of business on ensuring economic security is determined. It is noted that under the conditions of digitalization, the economic security of the enterprise is affected by various risks; the essence of the concept of "risk" is substantiated, and the considered threats are related to the digital transformation of the enterprise in terms of internal factors of economic security: personnel, technologies, information environment, management, property, finances, as well as the risks caused by these threats and the defined measures for their prevention. The principal risks of economic security in the conditions of digitalization of business are determined, the principles of risk management are considered, and the effectiveness of the risk management system to increase economic security is considered. Digital transformation of the enterprise has a significant potential for economic growth and technological breakthroughs of business entities. It is noted that it is necessary to monitor economic security based on a risk-oriented approach in a timely manner and to model the organizational design for the company's stakeholders.
Keywords: economic security, globalization, digitalization of business, digital transformation, threats, risks, risk management
Digital platforms in the economy: current trends and directions of development
Authors: Pysarevska Hanna , Kutsenko Tetyana , Martovitskiy Andriy
Published: December 2023

The article aims to substantiate current trends and develop directions for the development of modern digital platforms in the economy. The following main tasks were solved in the work to achieve the goal: to determine the peculiarities of the use of digital platforms in the economy, to determine the main problems and advantages of using digital platforms, to determine the main types and functions of digital platforms, to substantiate the main directions of the development of digital technologies. The main types of digital platforms are transactional, innovative, integration, and investment platforms, represented by a holding company that manages a portfolio of digital platforms. Transaction platforms reduce transaction costs between different types of individuals and legal entities when searching for each other. Innovation platforms are a technological lever for developing additional products and services by external innovators. Integration platforms involve the use of their transactional and innovative capabilities. The advantage of using investment platforms is the availability of backup infrastructure and the use of best practices of various brands and directions. The main functions of digital platforms are substantiated, namely attracting users, facilitating interaction, and finding matches. Identified sources of revenue for digital platforms include transaction fees, access fees, advanced access fees, and patronage fees. The main methods of digital marketing as one of the tools of digital platforms are substantiated: marketing in social networks, email marketing, mobile marketing, automatic marketing, search engine optimization, commercial marketing, and content marketing. The main directions of development of digital technologies are proposed, which include the introduction of unified digital standards, which involves the introduction of communication and information technologies with the creation and development of electronic management, as well as increasing the level of basic general digital literacy, the development of digital knowledge and the market; creation of a digital business environment; simplifying access to finance for businesses; formation and development of digital skills of employees, and creation of a supportive culture.
Keywords: digital platforms, transaction platforms, innovative platforms, investment sites, digitalization