bluuebunny/crossref_metadata_2025 huggingface dataset:
Industry-4.0-Enabled Digital Transformation: Prospects, Instruments, Challenges, and Implications for Business Strategies
Authors: Yaqub Muhammad Zafar , Alsabban Abdullah
Published: May 2023

Digital transformation, which significantly impacts our personal, social, and economic spheres of life, is regarded by many as the most significant development of recent decades. In an industrial context, based on a systematic literature review of 262 papers selected from the ProQuest database, using the methodology of David and Han, this paper discusses Industry 4.0 technologies as the key drivers and/or enablers of digital transformation for business practices, models, processes, and routines in the current digital age. After carrying out a systematic literature review considering key Industry 4.0 technologies, we discuss the individual and collective ways in which competitiveness in contemporary organizations and institutions is enhanced. Specifically, we discuss how these technologies contribute as antecedents, drivers, and enablers of environmental and social sustainability, corporate growth and diversification, reshoring, mass customization, B2B cooperation, supply chain integration, Lean Six Sigma, quality of governance, innovations, and knowledge related to dealing with challenges arising from global pandemics such as COVID-19. A few challenges related to the effective adoption and implementation of Industry 4.0 are also highlighted, along with some suggestions to overcome them.
The Role of Environmental Law in Farmers’ Environment-Protecting Intentions and Behavior Based on Their Legal Cognition: A Case Study of Jiangxi Province, China
Authors: Su Pinyi , Imran Muhammad , Nadeem Muhammad , Haq Shamsheer ul
Published: May 2023

Agriculture contributes to environmental degradation by using unsustainable farming practices, such as the intensive use of chemical fertilizers and fossil fuels. With China’s growing environmental concerns, new environmental laws have begun to disseminate information about environmental preservation among residents. This legislation plays a major role in developing individual behavior. Thus, the purpose of this study was to investigate the moderating role of environmental laws in relation to environment-protecting intentions and behavior based on their legal cognition. Based on 1350 randomly selected farmers from Jiangxi Province, we confirm the theory of planned behavior through a structural equation model. The results demonstrate that the perceived behavior control, personal factors, and attitude of farmers directly contribute to both types of farmer’s intentions, i.e., citizen and activist; and indirectly to both types of farmer’s environmental-oriented behavior (citizen and activist). The inward attitude effect was stronger than the outward attitude in both types of intentions of farmers. The farmers’ legal cognition also moderated their environment-protecting intentions and behaviors. This implies that as the farmer’s legal familiarity grows, the direct effect of both types of farmer’s intentions on the farmer’s environmentally oriented behavior continues to increase. Awareness programs, financial support, and extension services should be enhanced in rural areas, which may develop the farmers’ proenvironmental behavior and lead to them adopting environmentally friendly farm practices.
Collapsibility Mechanisms and Water Diffusion Morphologies of Loess in Weibei Area
Authors: Lv Yuanqiang , Zhang Changliang , Zhao Jingang
Published: May 2023

A large-scale immersion experiment was carried out to assess the collapsibility characteristics of loess in Bu Li village located in the Weibei Loess Tableland, and the seepage characteristics and collapsibility evolution of loess were determined. The effects of void ratio, natural moisture content, material composition, and microstructure evolution on the loess collapsibility were characterized by X-ray diffraction, scanning electron microscopy, and water-soluble salt analysis to elucidate the collapsibility mechanisms. The water diffusion morphologies considering various foundation lithologies, initial water contents, and stratum combinations were studied with the numerical simulation method, and an inverted-box-shape barrier measure preventing loess from the water immersion was proposed. The results showed that the maximum consolidation settlement was approximately 380.5 mm for the test site, and the expansion of clay minerals and the dissolution of soluble salts during wetting were the critical reasons for loess collapse. The void ratio and natural moisture content showed a positive and negative correlation with the collapsibility coefficient, respectively, and the concept of collapsibility potential was introduced. The water diffusion morphologies in distinct stratum combinations significantly depended on the permeability capacity of the lower soil layer, and the optimal depths of the vertical barrier were recommended to be set at the maximum inflection point in the diffusion morphology or the main action layer.
Contralateral Asymmetry in Cycling Power Is Reproducible and Independent of Exercise Intensity at Submaximal Power Outputs
Authors: Farrell John W. , Neira Valerie E.
Published: May 2023

The purpose of the current investigation was to examine the effects of exercise intensity on asymmetry in pedal forces when the accumulation of fatigue is controlled for, and to assess the reliability of asymmetry outcomes during cycling. Participants completed an incremental cycling test to determine maximal oxygen consumption and the power that elicited maximal oxygen consumption (pVO2max). Participants were allotted 30 min of recovery before then cycling at 60%, 70%, 80%, and 90% of pVO2max for 3 min each, with 5 min of active recovery between each intensity. Participants returned to the laboratory on separate days to repeat all measures. A two-way repeated measures analysis of variance (ANOVA) was utilized to detect differences in power production AI at each of the submaximal exercise intensities and between Trials 1 and 2. Intraclass correlations were utilized to assess the test–retest reliability for the power production asymmetry index (AI). An ANOVA revealed no significant intensity–visit interactions for the power production AI (f = 0.835, p = 0.485, η2 = 0.077), with no significant main effects present. ICC indicated excellent reliability in the power production AI at all intensities. Exercise intensity did not appear to affect asymmetry in pedal forces, while excellent reliability was observed in asymmetry outcomes.
Cubic Chemical Autocatalysis and Oblique Magneto Dipole Effectiveness on Cross Nanofluid Flow via a Symmetric Stretchable Wedge
Authors: Nasir Nor Ain Azeany Mohd , Sajid Tanveer , Jamshed Wasim , Altamirano Gilder Cieza , Eid Mohamed R. , ElSeabee Fayza Abdel Aziz
Published: May 2023

Exploration related to chemical processes in nanomaterial flows contains astonishing features. Nanoparticles have unique physical and chemical properties, so they are continuously used in almost every field of nanotechnology and nanoscience. The motive behind this article is to investigate the Cross nanofluid model along with its chemical processes via auto catalysts, inclined magnetic field phenomena, heat generation, Brownian movement, and thermophoresis phenomena over a symmetric shrinking (stretching) wedge. The transport of heat via nonuniform heat sources/sinks, the impact of thermophoretic diffusion, and Brownian motion are considered. The Buongiorno nanofluid model is used to investigate the impact of nanofluids on fluid flow. Modeled PDEs are transformed into ODEs by utilizing similarity variables and handling dimensionless ODEs numerically with the adoption of MATLAB’s developed bvp4c technique. This software performs a finite difference method that uses the collocation method with a three-stage LobattoIIIA strategy. Obtained outcomes are strictly for the case of a symmetric wedge. The velocity field lessens due to amplification in the magneto field variable. Fluid temperature is amplified through the enhancement of Brownian diffusion and the concentration field improves under magnification in a homogeneous reaction effect.
Security Concepts in Emerging 6G Communication: Threats, Countermeasures, Authentication Techniques and Research Directions
Authors: Kazmi Syed Hussain Ali , Hassan Rosilah , Qamar Faizan , Nisar Kashif , Ibrahim Ag Asri Ag
Published: May 2023

Challenges faced in network security have significantly steered the deployment timeline of Fifth Generation (5G) communication at a global level; therefore, research in Sixth Generation (6G) security analysis is profoundly necessitated. The prerogative of this paper is to present a survey on the emerging 6G cellular communication paradigm to highlight symmetry with legacy security concepts along with asymmetric innovative aspects such Artificial Intelligence (AI), Quantum Computing, Federated Learning, etc. We present a taxonomy of the threat model in 6G communication in five security legacy concepts, including Confidentiality, Integrity, Availability, Authentication and Access control (CIA3). We also suggest categorization of threat-countering techniques specific to 6G communication into three types: cryptographic methods, entity attributes and Intrusion Detection System (IDS). Thus, with this premise, we distributed the authentication techniques in eight types, including handover authentication, mutual authentication, physical layer authentication, deniable authentication, token-based authentication, certificate-based authentication, key agreement-based authentication and multi-factor authentication. We specifically suggested a series of future research directions at the conclusive edge of this survey.
Evaluation of Acute Toxicity and Antioxidant Response of Earthworm Exposed to a Lignin-Modified Crosslinked Hydrogel
Authors: Jiménez Humberto D. , Orozco Eulogio , Hernández Saira L. , Ramírez Ana C. , Velázquez José M. , Velazquez Gilberto , Minjarez Amelia del C. , Zamudio Adalberto , Flores Milagros M. , Velasco Sandra F.
Published: May 2023

Hydrogels are polymers of great importance due to their multiple applications, which have led to an exponential increase in their production. However, once they have fulfilled their function, they become waste and their ecotoxicological effects are unknown. The aim of the present study was to evaluate the acute toxicity and total antioxidant capacity of the earthworm (Eisenia fetida) exposed to a terpolymeric hydrogel (acrylic acid, acrylamide, and 2-acrylamido-2-methyl-1-propane-sulfonic acid) crosslinked with modified kraft lignin. Four different amounts of hydrogel per unit area were evaluated (0.0924, 0.1848, 0.9242, and 1.848 mg hydrogel/cm2) plus a control, and three replicates were performed for each group. Starting from the amount of 0.1848 mg hydrogel/cm2, the earthworms showed physiological and behavioral alterations; at higher amounts, 0.9242 and 1.848 mg hydrogel/cm2, more acute signs were observed with mortality rates of 51.7% and 100%, respectively. On the other hand, the antioxidant activity assay showed that the higher the hydrogel exposure amount, the higher the oxidative stress, as evidenced by lower antioxidant activity (67.09% inhibition of the ABTS●+ radical). Therefore, we concluded that the lignin-modified hydrogel generated oxidative stress and acute lethal toxic effects in Eisenia fetida.
Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish
Authors: Kim Yeonhwa , Kim Seong Soon , Park Byeong Heon , Hwang Kyu-Seok , Bae Myung Ae , Cho Sung-Hee , Kim Suhyun , Park Hae-Chul
Published: May 2023

Bisphenol F (BPF; 4,4′-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae.
Cognitive Predictors of Posttraumatic Stress in Children 6 Months after Paediatric Intensive Care Unit Admission
Authors: Dow Belinda L. , Kenardy Justin A. , Le Brocque Robyne M. , Long Debbie A.
Published: May 2023

This study aimed to identify predictors, especially cognitive predictors, of posttraumatic stress symptoms (PTSS) and posttraumatic stress disorder (PTSD) in children 6 months after Paediatric Intensive Care Unit (PICU) admission. Participants were 55 children aged 6–16, admitted to PICU for at least 8 h. Medical data were collected from patient charts. Cognitive variables (peri-trauma affect, cognitive processing and trauma memory) were assessed by interview and self-report questionnaires 2–4 weeks and 6 months following PICU admission. Acute PTSS at 2–4 weeks were assessed by self-report questionnaire and PTSD at 6 months was assessed by clinical interview. Receiving ketamine in PICU was the only non-cognitive variable associated with PTSS at 6 months. Peri-trauma affect, cognitive processing, and trauma memory significantly and independently accounted for 21% of the variance in PTSS at 6 months even after controlling for acute PTSS (and ketamine). A mediation analysis showed that peri-trauma affect indirectly influenced PTSS at 6 months through its effect on cognitive processing. Conclusions: Cognitive variables significantly contribute to PTSS in children, following PICU admission. Peri-trauma affect influenced PTSS only via disrupted cognitive processing. Prevention or early intervention strategies aimed at helping children develop a complete, contextual trauma narrative may be effective in reducing persistent posttraumatic stress responses in children following PICU.
A Theory about a Hidden Evander-Size Impact and the Renewal of the Intermediate Cratered Terrain on Dione
Authors: Bradák Balázs , Nishikawa Mayuko , Gomez Christopher
Published: May 2023

The study introduces a theory about an Evander-size impact on the surface of Dione. Our study suspects a relatively low-velocity (≤5 km/s) collision between a ca. 50–80 km diameter object and Dione, which might have resulted in the resurfacing of one of the satellite’s intermediate cratered terrains in various ways, such as surface planing by “plowing” by ricocheting ejectiles, ejecta blanket covering, partial melting, and impact-triggered diapir formation associated with cryotectonism and effusive cryo-slurry outflows. Modeling the parameters of an impact of such a size and mapping the potential secondary crater distribution in the target location may function as the first test of plausibility to reveal the location of such a collision, which may be hidden by younger impact marks formed during, e.g., the Antenor, Dido, Romulus, and Remus collision events. The source of the impactor might have been Saturn-specific planetocentric debris, a unique impactor population suspected in the Saturnian system. Other possible candidates are asteroid(s) appearing during the outer Solar System’s heavy bombardment period, or a collision, which might have happened during the “giant impact phase” in the early Saturnian system.
The Analysis and Verification of IMT-2000 Base Station Interference Characteristics in the FAST Radio Quiet Zone
Authors: Wang Jian , Zhao Yibo , Yang Cheng , Shi Yafei , Hao Yulong , Zhang Haiyan , Sun Jianmin , Luo Dingling
Published: May 2023

In this study, we aim to analyze the electromagnetic interference (EMI) regarding the Five-hundred-meter Aperture Spherical radio Telescope (FAST) caused by base stations in the International Mobile Telecommunications-2000 (IMT-2000) frequency band. By analyzing the frequency bands used by the transmitting and receiving devices and the surrounding environmental parameters and utilizing an approach to predicting radio wave propagation loss that is based on deterministic methods, we conclude by comparing the predicted received power at the FAST with its interference protection threshold. Our analysis demonstrates that, currently, only 55.31% of IMT-2000 base stations in the FAST radio quiet zone (RQZ) meet the protection threshold. Additionally, this article verifies the applicability and accuracy of the radio wave propagation model used in the research based on field strength measurements. Overall, this study provides valuable insights for improving the electromagnetic environment surrounding FAST and reducing the EMI caused by mobile communication base stations. It also provides corresponding analysis methods and useful suggestions for analyzing electromagnetic radiation interference in other radio telescopes.
A Decade of Pancreas Transplantation—A Registry Report
Authors: Gruessner Angelika C.
Published: May 2023

Since the first pancreas transplant in 1966, over 67,000 pancreas transplants have been performed worldwide and the number is growing. While the number of transplants in the US has changed only slightly over the past decade, many countries outside the US have shown strong growth in transplant numbers. The worldwide growth in numbers is due to the increasing number of patients with type 2 diabetes mellitus receiving a pancreas transplant. Only during the COVID-19 pandemic in 2020 and 2021 did transplant numbers decline, but they started to recover in 2022. The decline was especially noted for solitary transplants. This development over time was due to excellent patient and graft survival after simultaneous pancreas and kidney transplant (SPK). Patient survival at three years was >90% in SPK as well as in solitary transplants. At 3 years post-transplant, SPK pancreas graft survival was over 86% and SPK kidney graft survival over 90%. In pancreas transplants alone (PTA) and in pancreas after kidney transplants, the 3-year graft function reached 75%. The main reasons for advancement in outcome were reductions in technical failures and immunological graft losses. These improvements were due to better patient and donor selection, standardization of surgical techniques, and superior immunosuppressive protocols.
Querying Recombination Junctions of Replication-Competent Adeno-Associated Viruses in Gene Therapy Vector Preparations with Single Molecule, Real-Time Sequencing
Authors: Yip Mitchell , Chen Jing , Zhi Yan , Tran Ngoc Tam , Namkung Suk , Pastor Eric , Gao Guangping , Tai Phillip W. L.
Published: May 2023

Clinical-grade preparations of adeno-associated virus (AAV) vectors used for gene therapy typically undergo a series of diagnostics to determine titer, purity, homogeneity, and the presence of DNA contaminants. One type of contaminant that remains poorly investigated is replication-competent (rc)AAVs. rcAAVs form through recombination of DNA originating from production materials, yielding intact, replicative, and potentially infectious virus-like virions. They can be detected through the serial passaging of lysates from cells transduced by AAV vectors in the presence of wildtype adenovirus. Cellular lysates from the last passage are subjected to qPCR to detect the presence of the rep gene. Unfortunately, the method cannot be used to query the diversity of recombination events, nor can qPCR provide insights into how rcAAVs arise. Thus, the formation of rcAAVs through errant recombination events between ITR-flanked gene of interest (GOI) constructs and expression constructs carrying the rep-cap genes is poorly described. We have used single molecule, real-time sequencing (SMRT) to analyze virus-like genomes expanded from rcAAV-positive vector preparations. We present evidence that sequence-independent and non-homologous recombination between the ITR-bearing transgene and the rep/cap plasmid occurs under several events and rcAAVs spawn from diverse clones.
Evolution and Epidemic Spread of the Avian Infectious Bronchitis Virus (IBV) GI-23 in Brazil
Authors: Ikuta Nilo , Kipper Diéssy , Freitas Dayana Soriano Spencer de , Fonseca André Salvador Kazantzi , Lunge Vagner Ricardo
Published: May 2023

Infectious bronchitis virus (IBV) is a pathogen affecting poultry flocks worldwide. GI-23 is an IBV lineage with a rapid spread into different continents of the world, and it was reported for the first time in South American/Brazilian broiler farms last year. This study aimed to investigate the recent introduction and epidemic spread of IBV GI-23 in Brazil. Ninety-four broiler flocks infected with this lineage were evaluated from October 2021 to January 2023. IBV GI-23 was detected using real-time RT-qPCR, and the S1 gene hypervariable regions 1 and 2 (HVR1/2) were sequenced. S1 complete and HVR1/2 nucleotide sequence datasets were used to carry out phylogenetic and phylodynamic analyses. Brazilian IBV GI-23 strains clustered into two specific subclades (SA.1 and SA.2), both in tree branches with IBV GI-23 from Eastern European poultry-producing countries, suggesting two independent and recent introductions (around 2018). Viral phylodynamic analysis showed that the IBV GI-23 population increased from 2020 to 2021, remaining constant for one year and declining in 2022. S1 amino acid sequences from Brazilian IBV GI-23 presented specific and characteristic substitutions in the HVR1/2 for subclades IBV GI-23 SA.1 and SA.2. This study brings new insights into the introduction and recent epidemiology of IBV GI-23 in Brazil.
Comparison of West Nile Virus Disease in Humans and Horses: Exploiting Similarities for Enhancing Syndromic Surveillance
Authors: Schwarz Erika R. , Long Maureen T.
Published: May 2023

West Nile virus (WNV) neuroinvasive disease threatens the health and well-being of horses and humans worldwide. Disease in horses and humans is remarkably similar. The occurrence of WNV disease in these mammalian hosts has geographic overlap with shared macroscale and microscale drivers of risk. Importantly, intrahost virus dynamics, the evolution of the antibody response, and clinicopathology are similar. The goal of this review is to provide a comparison of WNV infection in humans and horses and to identify similarities that can be exploited to enhance surveillance methods for the early detection of WNV neuroinvasive disease.
Gastrointestinal Manifestations of SARS-CoV-2: Transmission, Pathogenesis, Immunomodulation, Microflora Dysbiosis, and Clinical Implications
Authors: Durairajan Siva Sundara Kumar , Singh Abhay Kumar , Saravanan Udhaya Bharathy , Namachivayam Mayurikaa , Radhakrishnan Moorthi , Huang Jian-Dong , Dhodapkar Rahul , Zhang Hongjie
Published: May 2023

The clinical manifestation of COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the respiratory system of humans is widely recognized. There is increasing evidence suggesting that SARS-CoV-2 possesses the capability to invade the gastrointestinal (GI) system, leading to the manifestation of symptoms such as vomiting, diarrhea, abdominal pain, and GI lesions. These symptoms subsequently contribute to the development of gastroenteritis and inflammatory bowel disease (IBD). Nevertheless, the pathophysiological mechanisms linking these GI symptoms to SARS-CoV-2 infection remain unelucidated. During infection, SARS-CoV-2 binds to angiotensin-converting enzyme 2 and other host proteases in the GI tract during the infection, possibly causing GI symptoms by damaging the intestinal barrier and stimulating inflammatory factor production, respectively. The symptoms of COVID-19-induced GI infection and IBD include intestinal inflammation, mucosal hyperpermeability, bacterial overgrowth, dysbiosis, and changes in blood and fecal metabolomics. Deciphering the pathogenesis of COVID-19 and understanding its exacerbation may provide insights into disease prognosis and pave the way for the discovery of potential novel targets for disease prevention or treatment. Besides the usual transmission routes, SARS-CoV-2 can also be transmitted via the feces of an infected person. Hence, it is crucial to implement preventive and control measures in order to mitigate the fecal-to-oral transmission of SARS-CoV-2. Within this context, the identification and diagnosis of GI tract symptoms during these infections assume significance as they facilitate early detection of the disease and the development of targeted therapeutics. The present review discusses the receptors, pathogenesis, and transmission of SARS-CoV-2, with a particular focus on the induction of gut immune responses, the influence of gut microbes, and potential therapeutic targets against COVID-19-induced GI infection and IBD.
Risk Factor Impact on African Swine Fever Transmission in Different Extensive Pig Production Settings in Serbia
Authors: Plut Jan , Hajdinjak Melita , Prodanov-Radulović Jasna , Grubač Siniša , Djurdjević Biljana , Štukelj Marina
Published: May 2023

The first case of ASF in a domestic pig population in Serbia was confirmed in 2019 in a backyard population. Today, outbreaks in wild boar and, more importantly, in domestic pigs are still occurring, although the government measures for ASF prevention are in place. The aim of this study was to determine critical risk factors and identify the possible reasons for ASF introduction into different extensive pig farms. The study was conducted on 26 extensive pig farms with confirmed ASF outbreaks, with data collected from beginning of 2020 to the end of 2022. Collected epidemiological data were divided into 21 main categories. After identifying specific values of variables as critical for ASF transmission, we identified nine important ASF transmission indicators as those variables for which at least 2/3 of the observed farms reported values critical for ASF transmission. Among them were type of holding, distance to hunting ground, farm/yard fencing, and home slaughtering; however, the hunting activity of pig holders, swill feeding, and feeding with mowed green mass were not included. We represented the data in the form of contingency tables to study associations between pairs of variables using Fisher’s exact test. All pairs of variables in the group including type of holding, farm/yard fencing, domestic pig–wild boar contact, and hunting activity were significantly related; hunting activity of pig holders, holding pigs in backyards, unfenced yards, and domestic pig–wild boar contact were observed on the same farms. Free-range pig farming led to observed domestic pig–wild boar contact on all farms. The identified critical risk factors need to be strictly addressed to prevent the further spread of ASF to extensive farms and backyards in Serbia and elsewhere.
Recent Developments and Future Perspectives of Vaccines and Therapeutic Agents against SARS-CoV2 Using the BCOV_S1_CTD of the S Protein
Authors: Gupta Amit , Singh Ashish P. , Singh Vinay K. , Sinha Rajeshwar P.
Published: May 2023

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, the virus kept developing and mutating into different variants over time, which also gained increased transmissibility and spread in populations at a higher pace, culminating in successive waves of COVID-19 cases. The scientific community has developed vaccines and antiviral agents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease. Realizing that growing SARS-CoV-2 variations significantly impact the efficacy of antiviral therapies and vaccines, we summarize the appearance and attributes of SARS-CoV-2 variants for future perspectives in drug design, providing up-to-date insights for developing therapeutic agents targeting the variants. The Omicron variant is among the most mutated form; its strong transmissibility and immune resistance capacity have prompted international worry. Most mutation sites currently being studied are in the BCOV_S1_CTD of the S protein. Despite this, several hurdles remain, such as developing vaccination and pharmacological treatment efficacies for emerging mutants of SARS-CoV-2 strains. In this review, we present an updated viewpoint on the current issues faced by the emergence of various SARS-CoV-2 variants. Furthermore, we discuss the clinical studies conducted to assist the development and dissemination of vaccines, small molecule therapeutics, and therapeutic antibodies having broad-spectrum action against SARS-CoV-2 strains.
Ischaemic Stroke Occurring in a Patient Treated with Monoclonal Antibodies for COVID-19
Authors: Lobasso Antonio , di Gennaro Ciro , Poggiano Maria Rita , Vasta Antonio , Ranucci Raffaele Angelo Nicola , Lobianco Roberto , Tucci Anna Giacoma , Cavaglià Enrico , Di Micco Pierpaolo
Published: May 2023

Since the COVID-19 outbreak began, an association between COVID-19 and thrombotic diseases has been underlined. Although this association is more frequent with venous thromboembolism, ischaemic stroke has also been reported as a thrombotic complication in several cohorts of affected patients. Furthermore, the association between ischaemic stroke and COVID-19 has been considered a risk factor for early mortality. On the other hand, after the successful vaccination campaign, the incidence and the virulence of SARS-CoV-2 decreased, though it has been observed that COVID-19 may induce a severe infection in specific cohorts of frail subjects. For this reason, different drugs have been introduced of an antiviral action in order to improve the disease outcome of frail patients. In this field, with the arrival of a neutralizing monoclonal antibody against SARS-CoV-2, in particular, sotrovimab, a further chance to treat high-risk patients with mild-to-moderate COVID-19 arrived, achieving a concrete reduction in the risk of disease progression. We here report our clinical experience of an ischaemic stroke occurring a few minutes after the administration of sotrovimab for the treatment of moderate COVID-19 in a frail patient with chronic lymphocytic leukaemia. Other causes of ischaemic stroke were ruled out, and in order to evaluate the probability of a rare side effect, the Naranjo probability scale has also been utilized. In conclusion, among several side effects that have been described during the treatment of COVID-19 with sotrovimab, ischaemic stroke was not reported. Therefore, we here report a rare case of ischaemic stroke with early clinical manifestation after the administration of sotrovimab for the treatment of moderate COVID-19 in an immunocompromised patient for the first time.
Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas
Authors: de Moraes Laise , Portilho Moyra M. , Vrancken Bram , Van den Broeck Frederik , Santos Luciane Amorim , Cucco Marina , Tauro Laura B. , Kikuti Mariana , Silva Monaise M. O. , Campos Gúbio S. , Reis Mitermayer G. , Barral Aldina , Barral-Netto Manoel , Boaventura Viviane Sampaio , Vandamme Anne-Mieke , Theys Kristof , Lemey Philippe , Ribeiro Guilherme S. , Khouri Ricardo
Published: May 2023

The Americas, particularly Brazil, were greatly impacted by the widespread Zika virus (ZIKV) outbreak in 2015 and 2016. Efforts were made to implement genomic surveillance of ZIKV as part of the public health responses. The accuracy of spatiotemporal reconstructions of the epidemic spread relies on the unbiased sampling of the transmission process. In the early stages of the outbreak, we recruited patients exhibiting clinical symptoms of arbovirus-like infection from Salvador and Campo Formoso, Bahia, in Northeast Brazil. Between May 2015 and June 2016, we identified 21 cases of acute ZIKV infection and subsequently recovered 14 near full-length sequences using the amplicon tiling multiplex approach with nanopore sequencing. We performed a time-calibrated discrete phylogeographic analysis to trace the spread and migration history of the ZIKV. Our phylogenetic analysis supports a consistent relationship between ZIKV migration from Northeast to Southeast Brazil and its subsequent dissemination beyond Brazil. Additionally, our analysis provides insights into the migration of ZIKV from Brazil to Haiti and the role Brazil played in the spread of ZIKV to other countries, such as Singapore, the USA, and the Dominican Republic. The data generated by this study enhances our understanding of ZIKV dynamics and supports the existing knowledge, which can aid in future surveillance efforts against the virus.
Analisis Perbandingan Teknik Peramalan Kebutuhan Obat Dengan Metode Arima Dan Single Eksponensial Smoothing Studi Kasus: Rsud Indramayu
Authors: Zahra Ilan Aliasi
Published: May 2023

Ketersediaan obat menjadi hal utama pada suatu layanan kesehatan. Fluktuasi pemakaian obat-obatan yang terjadi setiap tahun menjadi kendala bagian gudang obat dalam perencanaan pengadaan di rumah sakit. Peramalan (forecasting) merupakan alat bantu yang penting dalam pembuatan perencanaan bagi setiap organisasi maupun instansi yang membutuhkan. Penting bagi rumah sakit membuat perencanaan persediaan obat untuk mengatasi permasalahan berkaitan dengan ketersediaan alat kesehatan maupun obat-obatan. Tujuan dari penelitian ini yaitu untuk meramalkan kebutuhan obat dengan menggunakan teknik-teknik forecasting dan perhitungan nilai Economic Order Quantity. Sebuah forecasting atau tekik peramalan diperlukan, untuk memprediksi kebutuhan obat-obatan pada masa mendatang. Metode yang digunakan pada penelitian ini yaitu peramalan time series Arima untuk proses pengambilan prediksi dan perhitungan EOQ. Hasil penelitian ini berupa nilai peramalan kebutuhan obat untuk satu periode mendatang ditunjukan dengan nilai eror model peramalan yang paling kecil, yaitu ARIMA (1.0.0) dengan nilai eror sebesar 13%, serta hasil perhitungan Economic Order Quantity untuk kebutuhan obat pada periode mendatang.
Perancangan Arsitektur Enterprise Sistem Informasi pada SMA Terpadu Krida Nusantara Boarding School menggunakan Enterprise Architecture Planning TOGAF ADM
Authors: Putra Yeffry Handoko , Jafrudin Jafrudin
Published: May 2023

SMA Terpadu Krida Nusantara sebagai salah satu lembaga pendidikan formal di Indonesia dengan karakteristik

tersendiri. SMA Terpadu Krida Nusantara dirancang sebagai sekolah berasrama penuh (boarding school) yang mengacu pada kurikulum pendidikan nasional. Program pendidikan dirancang untuk melahirkan sekolah berasrama terkemuka dalam pengembangan potensi peserta didik di bidang akademik, keagamaan, dan keterampilan dengan disiplin sebagai landasan agar mampu bersaing di tingkat nasional maupun internasional. Penelitian ini bertujuan untuk melakukan perancangan sebuah model Enterprise Architecture serta melakukan implementasi terhadap roadmap yang dibuat agar menjadi mudah dalam mengembangkan information system architecture pada lembaga pendidikan dimasa mendatang. Peneliti melakukan penelitian di SMA Terpadu Krida Nusantara Boarding School. Dari hasil penelitian, didapatkan suatu rancangan business process dalam aktivitas yang berada di SMA Terpadu Krida Nusantara Boarding School dengan menggunakan Enterprise Architecture Planning TOGAF ADM dengan model Value Chain. Penelitian yang dihasilkan dapat diketahui mengenai lingkungan dari sistem business process yang berada di SMA Terpadu Krida Nusantara Boarding School terdiri dari tiga aktivitas utama yaitu PPDB, Kegiatan Belajar Mengajar, kelulusan dan alumni
Perancangan Basis Data Peseni, Pesilat dan Pendakwah di Kabupaten Bandung untuk Integrasi dengan Aktivitas KBRI Bangkok
Authors: Wahdiniwaty Rahma , Wahab Deden A , Putra Yeffry Handoko
Published: May 2023

Kegiatan Budaya di KBRI Bangkok yang mementaskan seni budaya Indonesia merupakan kegiatan terjadwal setiap tahunnya yang perlu untuk dikoordinasikan agar sesuai dengan hari-hari penting di Thailand. Aktivitas kegiatan termasuk pekerjaan non migran adalah para peseni, pesilat dan pendakwah yang berada di bawah tanggung jawab atase pendidikan dna kebudayaan. Perancangan data base ini menekankan pada kemudahan pencarian data dan verifikasi data untuk kegiatan rutin mempergunakan platform web. Hasil perancangan ini diusulkan sebagai kegiatan pengabdian pada masyarakat mandiri yang dikelola oleh universitas
PerancangannEnterprise Architecture Menggunakan ZachmannFramework di Unit LaboratoriumA Fakultas Ilmu Terapan Universitas Telkom
Authors: Handoko Refah Istifahani , Supatmi Sri
Published: May 2023

Abstrak :

Volume 8 Nomor 1, 2022, 32-43 ISSN: 2460-1799 P-ISSN: 1432-602743

Refah Istifahani Handoko, Sri Supatmi

Jurusan.Magister Sistem Informasi.UNIKOM Jl. Dipati Ukur No. 112-116, Bandung, Jawa Barat, Indonesia

rerefahanihan@gmail.com

PerancangannEnterprise Architecture Menggunakan

ZachmannFramework di Unit LaboratoriumA

Fakultas Ilmu Terapan Universitas Telkom

ZachmanaframeworkAmerupakanAsalahAsatu metodeAdibuat untuk perancangan model arsitektur enterprise yang dapat

mendukung semua manajerial organisasi atau perusahaan agar bisa lebih memahami secara keseluruhan enterprise. Sehingga, organisasi dapat memiliki kemampuan untuk menenapkan struktur dasar organisasiAyang membantu sistem intrgrasi, pengembangan interpretasi, penataan serta perbaikan arsitektur perangkat sistem informasi yang dimiliki organisasi. Tujuan dari penelitian ini adalah agar tercapainnya secara optimal antara strategi Sistem Informasi dan Teknologi Informasi dengan strategi bisnis dan hasil dari penelititian

ini adalah berupa Blue Print.

Kata kunci : Enterprise Architecture, Zachman Framework, EAP
Analisa dan Perancangan Enterprise Architecture Menggunakan TOGAF ADM
Authors: Nosa Ridho , Supatmi Sri
Published: May 2023

Dinas Perikanan Kabupaten Bengkalis merupakan organisasi pemerintahan dibawah naungan Kementrian Kelautan dan Perikanan Republik Indonesia memiliki sebuah Laboratorium Kesehatan Ikan dan Lingkungan (Kesling) yang memiliki 4 aktivitas utama yaitu layanan pengukuran kualitas air, layanan pengujian dan pengiriman sempel penyakit ikan, pengelolaan kesehatan ikan dan lingkungan, dan sosialisasi & edukasi ke pembudidaya ikan serta mahasiwa perikanan. Dengab 3 aktivitas pendukung yaitu pengelolaan perlengkapan laboratorium, pengelolaan administrasi laboratorium, dan pengelolaan keuangan laboratorium kesling. Dalam menjalankan tupoksi tersebut, Laboratorium Kesling Dinas Perikanan Kabupaten Bengkalis diharapkan dapat menyiapkan berbagai kebutuhan yang diperlukan, salah satunya adalah infrastruktur sistem informasi dan teknologi informasi (SI/TI) agar dapat meningkatkan efektifitas, produktifitas, serta efisiensi sehingga mencapai tujuan yang telah ditetapkan organisasi. Untuk itu dibutuhkan perencangan Enterprise Architecture (EA) dalam perancanaan SI/TI di Laboratorium Kesling Dinas Perikanan Kabupaten Bengkalis menggunakan framework TOGAF ADM yang akan menghasilkan panduan yang dapat dijadikan dasar untuk membangun dan mengembangkan aplikasi pada setiap aktivitas utama dan aktivitas pendukung yang dapat saling terintegrasi dan selaras dengan strategi bisnis pada Laboratorium Kesling Dinas Perikanan Kabupaten Bengkalis.
Rencana Audit Tata Kelola Sistem Informasi Di Universitas Subang Menggunakan Framework COBIT 2019
Authors: Destriani Maya , Putra Yeffry Handoko
Published: May 2023

Pemanfaatan sistem informasi pada perusahaan dapat mendukung operasional sebagai salah satu faktor untuk tercapainya rencana strategis dari organisasi. Universitas Subang merupakan lembaga perguruan tinggi swasta yang telah menggunakan sistem informasi sebagai serangkaian prosedur kerja yang menangani beberapa proses diantaranya Sistem Informasi Akademik, Sistem Informasi Keuangan, Sistem Informasi Audit Internal dan Sistem Informasi Penerimaan Mahasiswa Baru. Saat ini Lembaga Penjaminan Mutu (LPM) belum pernah melakukan audit internal untuk tata kelola Sistem Informasi yang ada di lingkungan Universitas Subang, sehingga diperlukan penyusunan rencana audit tata kelola sistem informasi untuk dapat membantu LPM dalam mengevaluasi kesesuaian kinerja maupun operasional dari sistem informasi yang telah berjalan dan orang yang terlibat didalamnya, Framework yang digunakan sebagai panduan Audit tata Kelola sistem informasi pada penelitian ini adalah Framework COBIT 2019, COBIT 2019 dipilih karena bersifat konseptual, fleksibel dan terbuka yang dapat disesuaikan dengan tujuan bisnis perusahaan. Adanya rencana audit tata kelola sistem informasi diharapkan dapat membantu auditor di Universitas Subang mengenai tahapan audit tata kelola sistem informasi untuk mengetahui tingkat kemampuan (capability level), berikut temuan dan rekomendasi dengan menggunakan Framework COBIT 2019.
Perancangan Enterprise Architecture Pada Pusat Inkubasi Di STMIK Widya Cipta Dharma dengan menggunakan Togaf ADM
Authors: Dwiguna Sumitra Irfan , Rahmadani Rizki Galang
Published: May 2023

Dinamika perubahan lingkungan dalam organisasi dan pesatnya perkembangan teknologi informasi menuntut setiap organisasi dapat beradaptasi untuk mendukung kelangsungan hidup organisasi dalam jangka panjang. Oleh karena itu, perlu dilakukannya sebuah perencanaan dan implementasi perancangan serta pengembangan arsitektur enterprise dan sistem informasi. Dirancang dengan baik, dapat disesuaikan dengan kebutuhan dan kemampuan organisasi. Desain yang baik tentunya akan membawa manfaat yang besar bagi desain atau pengembangan arsitektur enterprise. Sistem informasi harus dirancang dan disesuaikan dengan kebutuhan dan kemampuan organisasi. Mereka memiliki keuntungan besar dalam desain atau pengembangan arsitektur enterprise, baik dari segi sumber daya manusia, atau dari segi anggaran dan persiapan organisasi untuk rencana implementasi. Untuk mewujudkan sistem informasi, penelitian ini menggunakan struktur yang banyak digunakan dalam perancangan sistem informasi, yaitu TOGAF (Open Group Architecture Framework). STMIK Widya Cipta Dharma Penelitian ini sepenuhnya didasarkan pada langkah TOGAF ADM (Metode Pengembangan Arsitektur), yaitu konsep arsitektur perusahaan yang digunakan untuk manajemen perusahaan di unit pusat inkubasi, inovasi dan kewirausahaan.STMIK Widya Cipta Dharma Pengumpulan data, pra- penyaringan, fase visi arsitektur, fase arsitektur perusahaan, fase arsitektur sistem informasi, fase arsitektur teknis, keterampilan dan solusi, dan perencanaan migrasi. Hasil dari perancangan ini adalah model perancangan yang diharapkan dari arsitektur enterprise dan sistem informasi yang dikembangkan di Pusat Inkubasi, Inovasi dan Kewirausahaan STMIK Widya Cipta Dharma.
« Vous êtes sur France Inter... »
Authors: Donzelle Béatrice
Published: May 2023

Les émissions de France Inter dédiées aux médias constituent parfois une information complémentaire à celles du journal de la station, ou apportent une valeur ajoutée synthétique, analytique ou éditoriale au contenu de ces organes d’information. L’examen des différentes revues de presse offertes par une grande radio nationale comme France Inter illustre parfaitement, grâce à Béatrice Donzelle, l’intérêt que les médias portent aux médias.
Le service public underground
Authors: Koleva Maria , Méjean Jean-Max
Published: May 2023

L’acte de filmer a commencé à se démocratiser, les techniques actuelles permettent à chacun d’accomplir cet acte en toute liberté, construisant ainsi une sorte de culture médiatique nouvelle. Pour le constater, il suffit d’aller faire un tour sur Internet.
Fausses notes
Authors: Gaillard Jacques
Published: May 2023

La télévision est-elle si oublieuse d’elle-même qu’elle doive s’autocélébrer en permanence. La commémoration semble être devenu un genre obligé à la télévision mais, en oubliant l’autodérision, elle s’expose à la dérision de ses critiques. Dramatisation et nostalgie, dira-t-on, structurent la rhétorique de l’information télévisuelle.
Des espaces d'appropriation
Authors: Bonenfant Maude
Published: May 2023

L’espace de jeu affecte les utilisateurs. Mais il ne faut pas perdre de vue que les joueurs affectent, eux aussi, l’univers ludique.
Conjuguer propriétés des médias, logique commerciale et journalisme
Authors: Eveno Patrick
Published: May 2023

Quelle formation pour les journalistes dans l'univers impitoyable des industries médiatiques ? C'est en substance la question que pose Patrick Éveno en dressant un portrait réaliste de la situation économique des médias et des pouvoirs qui s''y exercent.
En Égypte : témoignage d'une expérience de formation
Authors: Morice Florence
Published: May 2023

Florence Morice, journaliste, a été responsable de la filière francophone de journalisme au Caire (Égypte) entre 2005 et 2007. Dans cet article, elle expose les raisons pour lesquelles le formateur étranger doit prendre en compte le contexte politique, sociologique et économique du pays où il dispense sa formation au risque de transposer un modèle journalistique français inadapté. Elle témoigne également de sa propre expérience de formatrice en Égypte où presse indépendante mais aussi «délit de presse » et arrestations de journalistes coexistent.
L'« auditeur engagé ». Les radios participatives en Amérique latine
Authors: Urioste Guglielmone Isabel
Published: May 2023

Les radios d’Amérique latine, en sollicitant la participation active des communautés auxquelles elles s’adressent, créent de nouveaux rapports sociaux, de nouveaux réseaux d’entraide, de nouveaux langages…
Pour un Ouvroir de Programmation Potentielle (OuProPo)
Authors: Landré Henri
Published: May 2023

On ignore encore trop souvent le rôle essentiel du programmateur musical dans la définition de l’identité de la radio à laquelle il est attaché. De simple robinet musical il devient créateur du son spécifique de la station qu’il anime.
Quel avenir pour la radiodiffusion internationale ?
Authors: Wuillème Bernard
Published: May 2023

Qui écoute les radios internationales ? Quels pays, hormis les plus puissants, peuvent-ils se permettre le luxe de financer de telles radios ? Quelles langues utiliser et à quelles fins ?
FSGS and COVID-19 in Non–African American Patients
Authors: Medina Elba , Rueda Carlos , Batlle Daniel
Published: May 2023

Collapsing Focal Segmental Glomerulosclerosis (FSGS) has been reported relatively frequently in African American (AA) patients with coronavirus disease 2019 (COVID-19), and it is associated almost always with Apolipoprotein L gen 1 (APOL1) high-risk variants. We reviewed the published literature from April 2020 to November 2022 searching for non–African American (non-AA) patients with FSGS associated with COVID-19 (eight White patients, six Hispanic patients, three Asian patients, one Indian patient, and one Asian Indian patient). The following histologic patterns were found: collapsing (n=11), not otherwise specified (n=5), tip (n=2), and perihilar (n=1). Fifteen of the 19 patients had AKI. The APOL1 genotype was reported in only six of the 19 non-AA patients. Three of them (two Hispanic patients and one White patient) with collapsing FSGS had high-risk APOL1 variants. The other three patients (two White patients and one Hispanic patient with the collapsing variant, tip variant, and not otherwise specified) had low-risk APOL1 variants. Among 53 African American patients with collapsing FSGS associated with COVID-19, 48 had high-risk APOL1 variants and five had low-risk APOL1 variants. We conclude that in non-AA patients, FSGS is a rare complication of COVID-19. FSGS associated with COVID-19 can occur rarely with low-risk APOL1 variants in non-AA and AA patients. Non-AA patients reported to be associated with high-risk APOL1 variants possibly reflect inaccuracy of self-reported race with AA admixture because of unknown ancestry. Given the importance of APOL1 in the pathogenesis of FSGS associated with viral infection and to avoid racial bias, it seems appropriate that APOL1 testing be considered in patients with FSGS associated with COVID-19, regardless of self-reported race.