bluuebunny/crossref_metadata_2025 huggingface dataset:
Brain Homogenate of a Rat Model of Alzheimer's Disease Modifies the Secretome of 3D Cultured Periodontal Ligament Stem Cells: A Potential Neuroregenerative Therapy
Authors: Mohebichamkhorami Fariba , Niknam Zahra , Khoramjouy Mona , Heidarli Elmira , Ghasemi Rasoul , Hosseinzadeh Simzar , Mohseni Seyedeh Sarvenaz , Hajikarim-Hamedani Arman , Heidari Amirhossein , Ghane Yekta , Mahmoudifard Matin , Zali Hakimeh , Faizi Mehrdad
Published: February 2023

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disease leading to neuronal cell death and manifested by cognitive disorders and behavioral impairment. Mesenchymal stem cells (MSCs) are one of the most promising candidates to stimulate neuroregeneration and prevent disease progression. Optimization of MSC culturing protocols is a key strategy to increase the therapeutic potential of the secretome. Objectives: Here, we investigated the effect of brain homogenate of a rat model of AD (BH-AD) on the enhancement of protein secretion in the secretome of periodontal ligament stem cells (PDLSCs) when cultured in a 3D environment. Moreover, the effect of this modified secretome was examined on neural cells to study the impact of the conditioned medium (CM) on stimulation of regeneration or immunomodulation in AD. Methods: PDLSCs were isolated and characterized. Then, the spheroids of PDLSCs were generated in a modified 3D culture plate. PDLSCs-derived CM was prepared in the presence of BH-AD (PDLSCs-HCM) and the absence of it (PDLSCs-CM). The viability of C6 glioma cells was assessed after exposure to different concentrations of both CMs. Then, a proteomic analysis was performed on the CMs. Results: Differentiation into adipocytes and high expression of MSCs markers verified the precise isolation of PDLSCs. The PDLSC spheroids were formed after 7 days of 3D culturing, and their viability was confirmed. The effect of CMs on C6 glioma cell viability showed that both CMs at low concentrations (> 20 mg/mL) had no cytotoxic effect on C6 neural cells. The results showed that PDLSCs-HCM contains higher concentrations of proteins compared to PDLSCs-CM, including Src-homology 2 domain (SH2)-containing PTPs (SHP-1) and muscle glycogen phosphorylase (PYGM) proteins. SHP-1 has a role in nerve regeneration, and PYGM is involved in glycogen metabolism. Conclusions: The modified secretome derived from 3D cultured spheroids of PDLSCs treated by BH-AD as a reservoir of regenerating neural factors can serve as a potential source for AD treatment.
The effect of neuroticism on problematic smartphone use: A mediation model of self-control for males and females
Authors: Liu Yanan , Wang Xiuna , Zhai Jiaqi , Luo Fang , Xin Tao
Published: February 2023

Exploring the effect of certain factors on problematic smartphone use (PSU) and the mechanism of these effects may help researchers understand the antecedents of PSU and propose targeted interventions. Accordingly, the current study tested the mediating role of self-control and the moderating role of gender in the relationship between neuroticism and PSU. A sample of 768 Chinese smartphone users (439 female, 329 male) aged 14–37 years (M = 22.5, SD = 3.27) completed questionnaires on neuroticism, self-control, nomophobia, and mobile phone addiction. The results showed that females reported significantly higher PSU than males. In addition, for females, self-control partially mediated the relationship between neuroticism and PSU, while for males, neuroticism had only a direct effect on PSU. The findings shed light on the effect of neuroticism on PSU and highlight the importance of gender in this effect.
Digital social multitasking (DSMT), digital stress, and socioemotional wellbeing among adolescents
Authors: Yang Chia-chen , Smith Christina , Pham Thomas , Ariati Jati
Published: February 2023

Phone use during face-to-face interactions has become increasingly common in adolescents’ social lives, but the mechanisms through which the behavior is associated with adolescents’ socioemotional wellbeing remain understudied. Drawing on the frameworks of digital social multitasking (DSMT) and digital stress, this study examined whether and how three types of digital stress (availability stress, connection overload, and fear of missing out) mediated the association between phone use in friendships and socioemotional wellbeing (depressive symptoms and friendship quality) among adolescents. A sample of 517 adolescents (Mage = 14.83, SD = 1.93) completed an online survey. Results showed that phone use during face-to-face interactions with a friend (i.e., DSMT) had an indirect relationship with greater depressive symptoms through all three types of digital stress. It also had an indirect relationship with better friendship quality via fear of missing out. The paths involving connection overload was moderated by the seriousness of the face-to-face interactions—in more serious interactions, DSMT had an indirect relationship with depressive symptoms, but not friendship quality; in less serious interactions, DSMT had an indirect relationship with friendship quality, but not depressive symptoms. Theoretical and practical implications are discussed.
Mongolian Ritual Texts in Manuscript Collections in the Czech Republic
Authors: Srba Ondřej
Published: February 2023

The present book is a critical edition of Mongolian ritual manuscripts preserved in Czech collections. It offers palaeographic descriptions and transcriptions for all the manuscripts, accompanied by English translations and selected facsimiles. The edition includes the majority of popular ritual text categories written in Classical Mongolian (mostly incense offering rituals) commonly circulating in the extramonastic milieu of premodern Mongolia: texts on fire-worship, White Old Man, Offering of the Fox, Geser Khan rituals, hunting rituals, while several texts related to cults of local deities, protection of livestock, as well as popular religious songs and individual prayers are appearing in the scholarly literature for the first time.
Hábitos y técnicas de estudio en estudiantes universitarios de nuevo ingreso, una revisión de la literatura
Authors: Espinosa González Ana Claudia , Suárez Flores Marina , González Hernández Maricruz , Aguirre Bravo Anna Alessandra
Published: February 2023

El presente artículo tiene como objetivo hacer una revisión comparativa de la literatura que permita obtener un panorama más claro respecto a la intervención de las instituciones de nivel superior para la detección de hábitos y técnicas de estudio en los estudiantes universitarios. El método es cualitativo y documental con un enfoque transversal simple, se utilizaron muestras homogéneas para la selección de los casos de estudio comparativo, eligiendo 17 autores. Respecto a las semejanzas encontradas, se pueden dividir en 4 rubros:
Implementación de programas educativos, por parte de las instituciones de nivel superior, enfocados a desarrollar hábitos y técnicas de estudio en el alumno de nuevo ingreso; el educando y la ausencia de hábitos y técnicas de estudio; el papel del docente, y su influencia en el uso de hábitos y técnicas de estudio, por parte del estudiante y ventajas de la existencia de conocimientos en este rubro.
Programas de parentalidad positiva en padres de niños con riesgo para el desarrollo: revisión sistemática
Authors: Robles-Martínez Elsa , Contreras Landgrave Georgina , Camacho Ruiz Esteban Jaime , Ibarra Espinosa Manuel Leonardo
Published: February 2023

Objetivo: Identificar artículos publicados los beneficios que obtuvieron los participantes de programas impartidos sobre parentalidad positiva. Con enfoque cualitativo, documental y retrospectivo, se realizó la búsqueda de artículos usando la pregunta diseñada según el acrónimo PICO. Se definió su búsqueda en cinco bases de datos: PubMed, Scielo, Google Académico, Microsoft Académico y Dialnet. El periodo de búsqueda fue de enero del 2018 a marzo 2022. parentalidad, programa, positiva y habilidad en español e inglés, con apoyo operadores boléanos and y or, siguiendo los parámetros PRISMA, para evaluar el riesgo de sesgo emplearon las herramientas del JBI para estudios preexperimentales y controlados aleatorizados. Se efectuó la revisión sistemática obteniendo como resultado diez estudios, que presentaron las características de creación y aplicación de programas de parentalidad positiva. Se concluyó que son programas con un alto índice de eficacia que requieren una especialización para su aplicación siendo intervenciones específicas para la población objetivo
Procrastinación de la cultura andina y educación intercultural en instituciones educativas bilingües distrito Huancayo Perú
Authors: Chamorro Mejia Rafael , Chamorro Llantoy Sara Pilar , Núñez Llantoy Ricardo Miguel
Published: February 2023

El artículo con el objetivo previo, determinar la relación que existe   entre la percepción de los docentes sobre procrastinación de la cultura andina y la educación intercultural en estudiantes de instituciones educativas bilingües distrito Huancayo Perú. El método fue guiado por el enfoque cuantitativo, de tipo descriptiva con diseño descriptivo correlacional, se trabajó con una muestra de 590 estudiantes, 60 Docentes, a quienes se administró los cuestionarios para recojo de datos. Los resultados indican, que, un alto porcentaje de encuestados perciben  a estudiantes que procrastinan la cultura andina en sus acciones y actitudes, de igual forma tienen dificultad en la educación intercultural en un alto porcentaje; por lo que se concluye: Existe correlación negativa muy baja entre procrastinación de la cultura andina y educación intercultural en estudiantes de instituciones educativas bilingües distrito de Huancayo Perú; con un coeficiente de correlación de Tau-b de Kendall igual a - 0,071.
CULTURAL SENSITIVITY IN THE PROCESS OF FORMING CROSS-CULTURAL TOLERANCE
Authors: Чистоградова Ольга Александровна , Ногинова Виктория Владимировна
Published: February 2023

В статье актуализируется формирование поликультурной личности, обладающей развитым чувством эмпатии и толерантности. Проанализирована модель развития межкультурной сензитивности, разработанная М.Беннетом. Представлены шесть этапов перехода монокультурной личности в поликультурную, результатом которого является высокий уровень сформированности межкультурной толерантности.

The formation of a multicultural personality with a developed sense of empathy and tolerance is being updated. The model of development of intercultural sensitivity developed by M. Bennett is analyzed. Six stages of the transition of a monocultural personality to a multicultural one are presented, the result of which is a high level of formation of cross-cultural tolerance.
ӨЛШЕУ ЖҮЙЕЛЕРІН ҚОЛДАНА ОТЫРЫП, БЕТОННЫҢ БЕРІКТІГІН БАҚЫЛАУДЫҢ НОРМАТИВТІК ТАЛАПТАРЫНЫҢ ЕРЕКШЕЛІКТЕРІ
Authors: ТУЛЕБЕКОВА А.С. , АХМЕТОВ Д.А. , РООТ Е.Н. , ЖАРАСОВ Ш.Ж.
Published: February 2023

Сегодня, рынок представлен различными видами измерительных систем для температурно-прочностного контроля бетона. Каждые из которых, имеют свои технические характеристики и особенности работы. Применение датчиков позволяет вести оперативный контроль. Согласно требованиям нормативов, расчеты прочности бетона могут выполняться по нескольким методам. В статье приведен сравнительный анализ данных методов. Выявлены преимущества и недостатки каждого из них.

Бүгінгі таңда нарықта бетонның температурасын және беріктігін бақылауға арналған өлшеу жүйелерінің әртүрлі түрлері ұсынылған. Олардың әрқайсысының өзіндік сипаттамалары мен жұмыс ерекшеліктері бар. Датчиктерді пайдалану жедел бақылауды жүзеге асыруға мүмкіндік береді. Нормативтік құжаттардың талаптарына сәйкес бетонның беріктігін есептеу бірнеше әдістермен жүргізілуі мүмкін. Мақалада осы әдістердің салыстырмалы талдауы келтірілген. Олардың әрқайсысының артықшылықтары мен кемшіліктері анықталды.

Today, the market is represented by various types of measuring systems for temperaturestrength control of concrete. Each of them has its own technical characteristics and peculiarities of work. The use of sensors allows for operational control. According to the requirements of regulations, calculations of the strength of concrete can be carried out by several methods. The article presents a comparative analysis of these methods. The advantages and disadvantages of each of them are revealed.
СЫМСЫЗ ЖЕЛІЛЕРДЕ САНДЫҚ СИГНАЛДАРДЫ ӨҢДЕУ ӘДІСТЕРІ
Authors: ДАРАЕВ А.М. , ДОМРАЧЕВ В.Н. , АКАНОВА Ж.Ж. , ТЛЕПБЕРГЕНОВА Г.Т.
Published: February 2023

В современном мире происходит бурный скачок в развитии цифровой связи. Сотовая и радиорелейная связь, передача данных по компьютерным сетям, цифровое радиовещание и телевидение, представленные в различных и многообразных форматах, охватили все страны мира. Значительное повышение скорости передачи цифровой информации по линиям связи требует разработки новых путей повышения качества передачи информационных потоков по каналам передачи информации, что в свою очередь нуждается в создании программно-аппаратных средств для решения такой проблемы. В статье рассмотрены причины искажений цифровых сигналов. Приведены методы борьбы с искажениями: разнесенный прием, разделение отдельных сигналов в точке приема с помощью использования широкополосных сигналов, прием с применением выравнивания частотных характеристик канала, использование OFDM.

Қазіргі әлемде цифрлық байланыстың дамуында қарқынды серпіліс бар. Ұялы және радиорелелік байланыс, деректерді компьютерлік желілер арқылы беру, сандық радиохабар және теледидар түрлі және алуан түрлі форматтарда ұсынылған, әлемнің барлық елдерін қамтыды. Байланыс желілері арқылы сандық ақпаратты беру жылдамдығының едәуір артуы ақпарат беру арналары арқылы ақпараттық ағындарды беру сапасын жақсартудың жаңа жолдарын әзірлеуді талап етеді, бұл өз кезегінде мұндай мәселені шешу үшін бағдарламалық және аппараттық құралдарды құруды қажет етеді. Мақалада сандық сигналдардың бұрмалану себептері қарастырылады. Бұрмаланулармен күресу әдістері келтірілген: кеңейтілген қабылдау, кең жолақты сигналдарды қолдану арқылы қабылдау нүктесінде жеке сигналдарды бөлу, арнаның жиілік сипаттамаларын теңестіру арқылы қабылдау, OFDM қолдану.

In the modern world, there is a rapid leap in the development of digital communications. Cellular and radio relay communications, data transmission over computer networks, digital radio broadcasting and television, presented in various and diverse formats, covered all countries of the world. A significant increase in the speed of digital information transmission over communication lines requires the development of new ways to improve the quality of information flows through information transmission channels, which in turn requires the creation of software and hardware to solve this problem. The article discusses the causes of digital signal distortion. The methods of dealing with distortion are given: spaced reception, separation of individual signals at the receiving point using broadband signals, reception using channel frequency characteristics equalization, use OFDM.
Meta-analysis on the relevance of Public Service Motivation (PSM) for public sector employees
Authors: Sudha Aminath , Ferdous Azam S.M. , Tham Jacquline
Published: February 2023

As there are very few conceptual papers to discuss the current relevance of Public Service Motivation (PSM) to public sector employees, the objective of the paper is to explore the significance of PSM in explaining public sector employees in recent history. The paper would highlight the development of the construct of Public Service Motivation (PSM) and how it is being used by researchers now, whether it is still a multidimensional concept as it was developed in the 1990s. The paper would provide an extensive understanding of the concept of PMS concerning public sector employees. This research would contribute to the existing body of literature, on the usefulness of PSM in understanding the behaviour of public sector employees. It fills the gap in PSM research, by providing a meta-analysis of the empirical studies of PSM, on some of the most common areas of studies of PSM, such as Job performance, Satisfaction, commitment, person-organization fit, and so on, while showing that there are limited studies on the dark side of PSM, which needs to be studied for future research perspective. Analysis based on existing research shows that PSM alone is not sufficient to create desired work-related outcomes for public sector employees, hence organization-related factors need to be improved to create meaningful work for public sector employees.
Cement Dust and Nephrotoxicity in Albino Rat
Authors: Ike Amalachukwu Okwukwe , Ogenyi Samuel Ifedioranma , Eberechukwu God’sman Chidugam , Achilefu Ramson Chinemerem , Blessing Okwuanaso Chetachi , Obinoma Joel Adienoye
Published: February 2023

With increasing infrastructural development in developing countries, the rise in the demand of cement has also increased which has resulted in the exposure of cement in the environment and the living organisms in the environment. The aim of this study was to assess the effect of duration of cement dust exposure on kidney organs in rats. A total of 25 rats were used for this study. The rats were divided equally into 5 groups (A, B, C, D and E) with each group having 5 rats. “A” group was not exposed to cement dust (control group); “B” group was exposed to cement dust for one hour daily for 15 days; “C” group was exposed to cement dust for one hour daily for 30 days; “D” group was exposed to cement dust for one hour daily for 45 days; E group was exposed to cement dust for one hour daily for 60 days. After the durational exposure, the rats were sacrificed, blood and kidney tissue harvested for biochemical assessment of kidney function and histological studies of the kidney. The result showed that there was significant difference in the levels of kidney function parameters (sodium, potassium, chloride, bicarbonate, urea and creatinine) amongst the groups. This was confirmed in the histological reports. This study has shown that durational exposure of rats to cement dust has great impact on the kidney.
Azithromycin for Eradication of Ureaplasma and Prevention of Bronchopulmonary Dysplasia in Preterm Neonates in the Neonatal Intensive Care Unit
Authors: Chang Eugenie , Ballard Kaci E. , Johnson Peter N. , Nandyal Raja , Miller Jamie L.
Published: February 2023

Azithromycin has been explored as a treatment option for eradication of Ureaplasma and prevention of bronchopulmonary dysplasia (BPD) in preterm neonates. However, there is debate about the need for eradication of Ureaplasma and whether azithromycin is safe and efficacious for this indication. This literature review provides an overview of the evidence for use of azithromycin for eradication of Ureaplasma and prevention of BPD, including dosing and duration of azithromycin used in these studies. The literature search included articles published in the English language in Medline and PubMed from 1946 to January 2022. Relevant citations within identified articles were also reviewed. A total of 9 studies representing 388 neonates were included. The percentage of neonates that tested positive for Ureaplasma in these studies ranged from 18.6% to 57.1%. Azithromycin was initiated at <3 days of life in 8 studies (88.9%). Dosing was variable and ranged from 5 to 20 mg/kg/dose administered once daily, and the duration of treatment ranged from 1 to 35 days. Most studies used intravenous azithromycin. Overall, azithromycin was more efficacious than placebo at Ureaplasma eradication; however, most of these studies did not find a difference in the incidence of BPD between patients receiving azithromycin versus placebo. No adverse effects, specifically pyloric stenosis or QT interval prolongation, were noted in these studies.
Effect of a Pharmacist Admission Medication Reconciliation Service at a Children's Hospital
Authors: Hovey Sara W. , Click Kristen W. , Jacobson Jessica L.
Published: February 2023

OBJECTIVE

To evaluate the clinical effect and estimate cost avoidance attributed to a pharmacist-led admission medication reconciliation service at a children's hospital.

METHODS

This was a prospective observational cohort study that measured pharmacist interventions for pediatric patients over a 90-day period. Pharmacists logged all interventions identified during medication reconciliation in real time. Patient demographic data were collected retrospectively. Cost avoidance from prevented adverse drug events (ADEs) was estimated based on previously published literature.

RESULTS

Pharmacists completed 283 admission medication reconciliations during the study period. Of those, 69% of medication reconciliations required intervention. Interventions affected care during the hospital admission in 21.9% of patients and 8 medication reconciliations resulted in prevention of a major ADE. This pharmacist-led service resulted in an estimated cost avoidance of $46,746.65 in the 3-month period.

CONCLUSIONS

Implementation of a pharmacist-led admission medication reconciliation service for pediatric patients improved medication safety and resulted in significant cost avoidance, which justifies investment in these pharmacist resources.
Characterization of Neutropenia in Preterm Neonates Following Administration of Darbepoetin Alfa
Authors: Andrews Nicole , Friedman Stephanie , Dunham Mary , Dean Roger , Chabra Shilpi
Published: February 2023

OBJECTIVE

This study is to evaluate the effects of darbepoetin alfa (darbe) on neutrophil count in preterm neonates treated for anemia of prematurity.

METHODS

This was a retrospective chart review comparing the absolute neutrophil counts (ANCs) of neonates administered 2 doses of subcutaneous darbe 10 mcg/kg to that of a randomly selected comparator group of neonates not administered the drug. Neonates <34 weeks gestational age, gestational age between 23w1d and 33w4d, born between July 2016 and June 2019, were included in the study.

RESULTS

The ANCs of 45 darbe-treated neonates compared with those of 45 randomly selected comparator control neonates revealed no difference in the rate of occurrence of neutropenia (ANC ≤1000/μL) between the darbe-treated neonates (26.7%) and comparator neonates (24.4%) (p > 0.99). There was also no difference in the rate of occurrence of severe neutropenia (ANC ≤500/μL) between the darbe-treated neonates (11.1%) and comparator neonates (6.7%) (p = 0.70). Darbepoetin alfa did not lead to differences in rates of resolution of neutropenia or severe neutropenia.

CONCLUSIONS

Short-term administration of darbe did not affect the ANCs of preterm neonates treated for anemia of prematurity. There was no difference in the rates of occurrence of neutropenia, severe neutropenia, or resolution of either between the darbe-treated neonates and comparator neonates.
Evaluation of Parenteral Potassium Supplementation in Pediatric Patients
Authors: Clouser Amanda A. , Merchan Cristian D. , Bashqoy Ferras , Tracy Joanna L. , Papadopoulos John , Saad Anasemon
Published: February 2023

OBJECTIVE

The primary objective was to evaluate the effect of parenteral potassium chloride (KCl) supplementation on potassium (K+) concentrations in a non-cardiac pediatric population. Secondary outcomes were to identify variables that may influence response to KCl supplementation (i.e., change in K+ concentration after KCl administration) and assess the incidence of hyperkalemia.

METHODS

This single-center, retrospective study evaluated infants and children who received parenteral KCl supplementation of 0.5 or 1 mEq/kg between January 2017 and December 2019.

RESULTS

The study included 102 patients with a median age of 1 year (IQR, 0.4–3.9) and weight of 9.1 kg (IQR, 4.9–14.2) who received 288 parenteral KCl administrations. One hundred seventy-three administrations were in the 1 mEq/kg group, and 115 administrations were in the 0.5 mEq/kg group. The median changes in K+ were 0.8 and 0.5 mEq/L in the 1 mEq/kg and 0.5 mEq/kg groups, respectively. Patients who had a repeat K+ concentration within 4 hours of the end of a 1 to 2–hour infusion had a higher median change in K+ compared with those who had a concentration drawn after this time frame (0.8 vs 0.6 mEq/L; p < 0.01).

CONCLUSIONS

There is a paucity of data on the correlation between parenteral KCl supplementation and change in K+ concentrations in pediatric patients. Our study demonstrated an association between KCl supplementation doses of 1 and 0.5 mEq/kg and changes in K+ of 0.8 and 0.5 mEq/L, respectively, in non-cardiac pediatric patients, with low observed incidence of hyperkalemia.
Targeting Lower Serum Trough Concentrations: A New Gentamicin Dosing Strategy for Suspected Neonatal Early-Onset Sepsis
Authors: Kayser Nicholas , Cunningham Kelli , Alabsi Samir , Smith Hayden
Published: February 2023

OBJECTIVE

Neonatal gentamicin dosing algorithms are not designed to achieve serum trough concentrations ≤1 mcg/mL. The purpose of our study was to evaluate a new gentamicin algorithm based on serum creatinine (SCr) and gestational age (GA) designed to achieve serum gentamicin trough concentrations ≤1 mcg/mL.

METHODS

A retrospective cohort study was conducted in a level IIIB neonatal intensive care unit. The incidence of elevated serum gentamicin troughs for this study was compared with the center's previously published results to evaluate the proposed dosing algorithm. Patients were included if gentamicin was administered within the first 7 days of life and a serum gentamicin trough concentration and a baseline SCr concentration were obtained. Patients were further subdivided into groups based on GA for data analysis: ≤30 weeks (group 1), 30–34 weeks (group 2), and ≥35 weeks (group 3). The SCr was considered mildly elevated (0.81–0.99 mg/dL) or elevated (≥1 mg/dL). The respective outcomes between the post-algorithm and control groups were examined using intention-to-treat analysis and Bayesian modeling to calculate rate differences.

RESULTS

Of the 2377 patients evaluated, 366 met the inclusion criteria. Significantly lower percentages of elevated serum gentamicin troughs were noted in groups 2 and 3 subsequent to the implementation of the dosing algorithm with 16% and 15% lower rate differences, respectively. Regardless of GA, there were significantly fewer elevated serum troughs in the post-implementation groups than in the control with mildly elevated and elevated SCr p < 0.001.

CONCLUSIONS

Using a dosing algorithm based on SCr significantly reduced the number of elevated serum trough rates in neonates with a GA greater than 30 weeks.
Treatment of Congenital Cytomegalovirus and Ganciclovir Therapeutic Drug Monitoring in Twin Preterm Infants
Authors: Piché-Renaud Pierre-Philippe , Chiasson Charles-Olivier , Autmizguine Julie , Ovetchkine Philippe , Lachance Christian , Théorêt Yves , Martin Brigitte
Published: February 2023

Congenitally acquired cytomegalovirus (CMV) infection is the most prevalent congenital infection worldwide and the most frequent cause of acquired sensorineural hearing loss. The burden of the disease is even more important in premature and very low birth weight infants. However, few data exist on the treatment with intravenous ganciclovir and oral valganciclovir in this vulnerable population. We report the case of twins congenitally infected with CMV and born prematurely at 27 weeks' gestation. Treatment regimens were initially individualized for their prematurity and renal function, and then adjusted with therapeutic drug monitoring (TDM) to adapt to their continuously evolving physiologic maturation. As infants were aging, the plasmatic half-life of ganciclovir slowly decreased to term infant values around 10 weeks of chronological age, or 37 weeks of postmenstrual age. Results for blood polymerase chain reaction tests became negative and long-term follow-ups were satisfactory in both twins. The limited data for infants born before 32 weeks of gestation or at less than 1200 g and evolution of ganciclovir pharmacokinetic parameters justify the use of TDM in these settings.
Development Of A Learning Module Using The Self Organized Learning Environment (Sole) Model With Augmented Reality Assistance On The Materials Of Rotation Dynamics And Equality Of Rigid Bodies
Authors: Rosniadi Pratama Oktaviyani , Connie Connie , Risdianto Eko
Published: February 2023

This research aims to describe the characteristics of the learning module by using the Self Organized Learning Environment (SOLE) model with the aid of Augmented Reality on the material of rotational dynamics and rigid body equilibrium, to describe the feasibility of the learning module using the Self Organized Learning Environment (SOLE) model with the aid of Augmented Reality on the dynamics material rotation and equilibrium of rigid bodies and describe students' perceptions of the readability of learning modules using the Augmented Reality-assisted Self Organized Learning Environment (SOLE) model on the material of rotational dynamics and rigid body equilibrium. This research method is a Research and Development (R&D) method with a 4D development method modified into 3D, namely define, design and development. The resulting product is a printed learning module using the Self Organized Learning Environment (SOLE) learning model assisted by Augmented Reality video playback made using the Unity 3D application. This module aims to train high school students critical thinking skills. The data samples used in this study were physics teachers and class XI students from three schools. The instruments used in this study were observation sheets, review sheets of learning implementation plan documents, the teacher needs questionnaires, student needs questionnaires, expert team validation questionnaires, and student perceptions questionnaires. Assessment of the validation test questionnaire and students' perceptions were interpreted with a Likert scale. Product validation was carried out by 3 expert validators who were reviewed from 6 aspects, namely content, presentation, critical thinking indicators, language, SOLE model stages, and media. The results obtained from this study indicate that the developed module is included in the very decent category with an average score percentage of 85.96% and students' perceptions of the developed module are in the very good category with an average score percentage of 90.01%.
Students Perception of Readability of Comic-Based Physics Ethnoscience Learning Media on Sound Wave Material Using Microsoft PowerPoint Application
Authors: Diani Sari Selly
Published: February 2023

This study aims to conduct a readability test in order to describe students' perceptions of comic-based physics ethnoscience learning media on sound wave material using the Microsoft PowerPoint application. This type of research is development research. The research instrument used was a student perception questionnaire with 10 questions given to 30 respondents who were students in 3 schools, namely SMA Negeri 1, SMA Negeri 6 and SMA Negeri 9 Bengkulu City. In this study, data analysis used quantitative descriptions. Based on the results of the data obtained, it can be concluded that the comic-based physics ethnoscience learning media on sound wave material using the Microsoft PowerPoint application is very good based on the perceptions of students. This is based on the data obtained that of all statements regarding the readability of comic-based physics ethnoscience learning media, almost all of them were answered with the largest percentage being in the very good and good answer choices. This means that students agree with the statements offered on each question they fill in the perception sheet. Based on the data obtained, the average percentage of content quality aspect is 83%, the aspect of time allocation is 80% and the grammatical aspect is 87.5%. So it can be concluded from these three aspects that the module developed is very good with an overall average percentage of 83.5%.
Development of E-Module Materials of Quantities and Units Using Canva to Increase Students' Interest in Learning
Authors: Wulandari Dinda , Risdianto Eko , Setiawan Iwan
Published: February 2023

This study aims to determine the characteristics and feasibility of developing an e-module using the Canva application to increase the learning interest of high school students. This research is a follow-up research that has been done previously which is only limited to the analysis stage, this research uses the ADDIE model RnD method. But in this research, it is only up to the development stage. This study uses an expert validation sheet assessment instrument that contains aspects of material, language and media. Based on the results of product validation tests that were validated by experts so that the percentage score for the material aspect was 85.45%, language was 87.50%, media was 89.58%, and interest in learning was 90.63%. The final result of the average score is 88.28%, can be categorized as very valid and the results of the student's perception response show very well with a percentage of 86.23%. Therefore, the e-module material of magnitude and unit using Canva to increase the learning interest of high school students is declared as a product that is feasible to use.
Response about the Importance of Digital Marketing Skills for Vocational Teachers
Authors: Firdaus Firdaus , Wahyuni Sungkem Tri , Risdianto Eko
Published: February 2023

This study aims to analyze responses about the importance of digital marketing skills for vocational teachers. This type of research is survey research using quantitative research methods. The sample in this study were 41 teachers at SMKN 2 North Bengkulu. The research was conducted in November 2022. The data collection technique used a questionnaire so that the measuring tool was a questionnaire made with a modified Likert scale with 4 answer choices, namely strongly agree, agree, disagree, and strongly disagree. The results of the study show that digital marketing skills are important for vocational teachers.
Decision Support System for Determining the Best Customer Using the Simple Multi-Attribute Rating Technique (SMART)
Authors: Rosalina Vidila , Agustiawan Wahyu , Purnamasari Ayu
Published: February 2023

Jaya Bila Makmur is a nine-ingredient grocery store with products sold including cooking oil, instant noodles, rice, margarine, sugar, salt, and so on. With the continuous increase in the number of similar grocery stores on the market, business owners must have a strategy so that customers remain loyal and don't move elsewhere. One of the strategies is to give rewards or gifts to loyal customers for their cooperation so far, but the decisions taken by business owners are still not quite right. Then a decision support system (DSS) is needed that is able to provide alternative solutions. This system was built using PHP and MySQL, modeled using UML, and tested with Blackbox Testing. The method used in DSS uses the Simple Multi-Attribute Rating Technique (SMART) for multi-criteria decision making. The findings of this study are intended to assist in identifying the best customers who shop frequently and will become repeat customers. By implementing this decision-support system, business owners can improve their competitiveness and competence in the business world. From the results of the application built, it is hoped that it will make it easier for users to choose and determine the best customers according to the specified criteria.
New and Old South Elementary School
Authors: Peters Gary
Published: February 2023

A case study of demographics in elementary schools.
Teacher Personality Competence in Educating Early Childhood Characters through Jasmine Solusi Playgroups in Cimahi City
Authors: Yulianti Fiyul Arfiani
Published: February 2023

This study aims to analyze the personality competence of teachers in educating early childhood characters. Through play groups. Methods This research uses a qualitative approach by describing what was carried out in the Jasmine Solusi play group in Cimahi City. Data collection techniques through, namely observation, interviews, and documentation studies. Data analysis techniques in this study include Domain, Taxonomy, Componential, and cultural themes. As for checking the validity of the data using triangulation techniques. In conclusion, the teacher's personality competence in forming early childhood character in the Jasmine Solusi Playgroup, Cimahi City. Jasmine Solusi educational staff. Have a personality capable of showing discipline, loyalty, and responsibility. The inhibiting factors causing the teacher's lack of discipline are Jasmine Solutions, which consists of external factors such as the condition of the teacher being very far from the teaching place and vehicles that are not always there. As for the efforts of the principal in improving the competence of the teacher's personality in increasing discipline, loyalty, and teacher responsibility, namely the efforts and leadership of the principal, namely monitoring, and fostering, teacher performance, so that sanctions and rewards will be given to the teacher.
Entrepreneurship Management for Education Financing Management of Modern Islamic Boarding Schools
Authors: Handayani Dewi Dyah
Published: February 2023

This research is to analyze the concept of entrepreneurship strategic planning, Implementation of entrepreneurship strategic in managing education financing, Evaluation of entrepreneurship strategic of Modern Islamic Boarding School. The contribution and impact of strategic entrepreneurship of Modern Islamic Boarding Schools in financing and developing education. This research method uses a qualitative approach. Data collection techniques using interviews, participant observation and documentation studies. The results of this study indicate that: (1). Planning by functioning the resources owned, by marketing products, through emotional and professional approaches, making financial projections, determining member investment capital, making production based on sales results (2). Implementation of the program, motivating teachers and staff by the leadership (3). Evalusai startegis entrepreneurship in Pondok Moderen every three months, annually with management supervision (4) The contribution and impact of strategic entrepreneurship on financing, the budget of all educational programs, facilities and facilities, human resource development, scholarships for students, the availability of cheap education.
Implementasi Kampus Merdeka: Implikasi pada Mahasiswa Perguruan Tinggi Negeri di Aceh Barat
Authors: Safrida Nila
Published: February 2023

Learning outside of the study program is one of the programs offered by the Independent Campus Policy, which is a new policy in the field of education. The study will concentrate on student exchange programs, internships, and village development, all of which should be evaluated for their feasibility. This study employs a qualitative technique using a case study approach, and the research indicator is David C. Korten's theory of compliance. The findings suggest that not all PTNs in West Aceh have adopted the Merdeka Campus. Although the Merdeka Campus policy has been designed to meet the demands of students, students have complained about rising living costs and the lack of precise criteria for each activity. The implementing organization in charge of the program is ineffective because there are still activities without a competent agency. The target group, students, believe that the program's implementing organization is inconsistent in formulating and issuing policies, which has a detrimental influence on students. It can be concluded that PTN has attempted to implement the independent campus policy in West Aceh, and that this is viewed positively by students; however, improvements are required so that the results of the implementation of an independent campus can provide the best results for improving the quality of higher education in West Aceh.
Peran Teknologi Digital dalam Meningkatkan Motivasi Belajar Siswa
Authors: Rahmana Sari Leli
Published: February 2023

The purpose of this study was to find out information or analyze the role of digital technology in increasing student motivation. Digital technology is an important tool in the learning process in the era of the industrial revolution 4.0 so that in all domains it is expected to be able to apply it, including the field of education, which in fact is students who study three years in school who are the successors of the next generation who are required to be able to compete in technological developments. This study uses a qualitative method with a case study approach using purposive techniques and snowball sampling to obtain data from resource persons at the State Vocational High School 1 Simpang Kiri Subulussalam City majoring in Multimedia. Furthermore, the findings or results in research that the role of digital technology in the multimedia department is able to provide learning motivation for students to be able to create innovative and creative works so that with the application of digital technology in learners can produce productive students. However, facilities such as computers in schools are not adequate or not enough to meet computer-based education standards, which are still minimal. So, it is hoped that for the next generation the computer facilities have been fulfilled in order to create effective learning.
Analisis Pelaksanaan Pengelolaan Sampah di Kabupaten Aceh Barat
Authors: Yulianita Yulianita , Mursyidin Mursyidin , Siregar Wardah Muharriyanti
Published: February 2023

The ratification of West Aceh District Regulation (Qanun) Number 4 of 2017 concerning waste management has become a guideline for the West Aceh District government to achieve solid waste management objectives. The regional regulation guarantees legal certainty, clarity of responsibility of the authority of the regional government, the participation of the community and the business sector / private sector so that waste management can run effectively and efficiently. The purpose of this study was to determine the implementation of Qanun Number 4 of 2017 Article 10 concerning waste management in West Aceh Regency in 2019. The method used in this study was to use a qualitative descriptive approach. Data collection techniques used are documentation and interviews. The informants in this study were 8 people. Data analysis was performed using qualitative data analysis techniques. The results showed that the implementation of Qanun Number 4 of 2017 Article 10 concerning waste management in West Aceh District Year 2019 in waste reduction was still not optimal, this was due to the lack of effort and management of the government in managing waste in the community environment such as lack of facilities and infrastructure in management garbage. There are still many piles of rubbish on the edges of the highway that make West Aceh District still look dirty and dirty. For the handling of waste carried out by the Office of Environment of West Aceh District Head is not optimal, this is because the lack of cleaners is also a major factor in the failure of waste management. There has been no firm action from the government on waste management efforts such as the implementation of West Aceh District Qanun Number 4 of 2017 Chapter XVII on Article 63 Criminal Provisions and lack of socialization from the government on waste management so that public awareness in managing waste is still reduced
Implementasi Peraturan Daerah Provinsi Riau Tentang Penanggulangan Bencana Alam di Kabupaten Kuantan Singingi
Authors: Rahayu Indri , Sujianto Sujianto
Published: February 2023

Kuantan Singingi Regency is an area located near the Kuantan river, where natural disasters often occur in the river flow such as floods due to overflowing of the Kuantan river. To overcome these natural disasters, it is necessary for the local government to be agile in pursuing policies on how to cope with these natural disasters. This study uses a qualitative method which is carried out by asking questions and procedures, collecting data from participants, analyzing data inductively, and interpreting the meaning of the data. This study uses a descriptive approach which carefully records all phenomena (symptoms) that are heard, seen, and read through official documents, field notes, interviews, and personal documents. Data was collected using primary and secondary data with data collection techniques using interviews, observation, and documentation. The results in this study indicate that in dealing with natural disasters, especially floods in the Kuantan Singingi area, the government has collaborated with the Riau Province BPBD but it is still not optimal because in the Kuantan Singingi Regency area there is no BPBD, making it difficult to coordinate and give orders centrally. Therefore, more concrete policies are needed regarding disaster management in Kuantan Singingi Regency.
Strategi Pemerintah Simeulue dalam Penanganan Prevalensi Stunting pada Anak Balita
Authors: Susanti Miri , Mardhiah Nellis
Published: February 2023

Stunting is a condition of failure to thrive in toddlers, the government continues to campaign about the dangers of stunting, and stunting in Simeulue district is the 2nd highest in Aceh, so it is very necessary to handle this case. Based on the Simeulue Regent's Regulation Number 13 of 2019 concerning Integrated Stunting Prevention and Handling in the Village, it is based on the election of Simeulue Regency as the national stunting locus set by the Central Ministry. The determination was ratified through the decision of the head of the Netional Development Planning Agency of the Republic of Indonesia number 42 of 2020. The cause of the high stunting rate in Simeulue is the lack of nutrition in children under five, which stems form the lack of funds and posyandu facilities such as measuring instruments and weighing equi [ment (dacing) which are not fully available at every posyandu.  The purpose of this study is to describe the Government's strategy in overcoming the prevalence of stunting in children under five in Simeulue Regency and how the government’s efforts in builing cooperation with the perties hendling stunting prevention in children under vive in Simeulue Regency. Using qualitative methods and data obtained from interviews with Mr. Andre as the head of the social welfare sub-sector and then analyzed. The results of the research, the government carried out eight stunting convergence actions and each action has its own implementation instrument and givernment also involves stakeholders to reach out
Análise linguística: ensino de variação lexical no livro didático de português do ensino médio
Authors: Lima Carlos Álack de , Silva Carlos Roberto Gonçalves da , Florencio José Herbertt Neves
Published: February 2023

Neste artigo, analisamos atividades de análise linguística (AL) que tratam da variação lexical de três livros didáticos do PNLD 2021, objetivando descrever e analisar como as atividades voltadas ao tratamento da variação lexical são apresentadas e a qual perspectiva de AL as atividades se associam. Fundamentam nosso trabalho os conceitos de análise linguística (REINALDO, 2012), as perspectivas de análise linguística em LDs (BEZERRA; REINALDO, 2020), a BNCC (BRASIL, 2018). Constatamos que o trabalho com a variação lexical se dá por meio da substituição do item lexical, isto é, o ensino do léxico ocorre baseado na sinonímia.
Personalized medicine: overview and comparison of challenges and opportunities for its implementation in the Brazilian public healthcare system (SUS)
Authors: de Moraes Amanda da Cruz Nunes , Stuchi-Maria-Engler Silvya
Published: February 2023

The objective of this work is, through a literature review, to promote the debate on personalized medicine and acquire a broad view of the subject and its tools from the perspective of oncology, disseminate the topic, support, and encourage initiatives to implement its technologies in the Brazilian public healthcare system, collaborating for a sustainable ecosystem in the incorporation of technologies, and above all, with the health and quality of life of patients. The implementation of personalized medicine technologies in SUS is feasible and effective. The scenario is optimistic considering the latest updates from the Ministry of Health with the establishment of the Brazilian Genomes Program. With wise management of resources and actions focused on creating an infrastructure that supports it, the entire public healthcare system will be benefited and can take advantage of the improvements. Personalized medicine is the future of healthcare.