bluuebunny/crossref_metadata_2025 huggingface dataset:
L’innovation et le transfert de technologie issus de la recherche publique : Inserm Transfert, une stratégie axée sur la compétitivité internationale et la vision à long terme
Authors: Augé Pascale
Published: November 2023

Dans le secteur des biothérapies et de la bioproduction, le transfert de technologie depuis la echerche publique vers l’industrie revêt une importance capitale. Cet article met en lumière le rôle clé d’Inserm Transfert dans cette dynamique. En s’appuyant sur des exemples concrets et des succès marquants, il explore les étapes cruciales du transfert, de l’identification des découvertes prometteuses à la valorisation des innovations. Les collaborations avec l’industrie et le soutien aux start-up jouent un rôle central dans cette démarche, offrant un aperçu de l’écosystème en constante évolution qui façonne l’avenir des traitements médicaux.
La bioproduction en thérapies cellulaires : le cas des CAR-T cells par la plateforme MEARY
Authors: Larghero Jérôme , Decoopman Stéphanie , Menasché Philippe
Published: November 2023

La France se situe au deuxième rang en Europe pour la production de médicaments biologiques, qui représente une part croissante du marché mondial du médicament. La préservation du leadership français dans ce domaine suppose de concilier enjeux éthiques, technologiques, financiers et réglementaires. La France dispose d’atouts dans ce secteur très concurrentiel, mais doit encore faire émerger une filière pour assurer la transition entre les travaux de R&D, les essais cliniques et la phase d’industrialisation, et étendre ses capacités de production. Le Centre MEARY, dédié à la fabrication des médicaments de thérapies cellulaires et géniques, sur le site de l’hôpital Saint-Louis de l’Assistance Publique - Hôpitaux de Paris peut jouer un rôle décisif pour transformer l’excellence, le savoir-faire et les technologies de rupture de nos chercheurs et start-up en briques articulées vers l’innovation et l’industrialisation. Depuis sa création en 2020, le Centre MEARY a pour ambition de faciliter la transition vers la clinique en proposant un processus simplifié. Il a déjà développé de nombreux projets académiques et conclu plusieurs partenariats industriels. Par ce projet, l’AP-HP contribue à structurer et animer l’offre médicale et scientifique autour de la bio-production des médicaments de thérapie innovante, dans le cadre global de sa stratégie d’innovation.
L’industrialisation des thérapies géniques : l’exemple d’Yposkesi
Authors: Lamproye Alain
Published: November 2023

La thérapie génique est l’un des secteurs à la croissance la plus rapide dans le domaine des sciences de la vie, avec des perspectives de forte évolution dans les prochaines années. Les perspectives laissent entrevoir que 20 des nouveaux médicaments atteignant la mise sur le marché à l’horizon de 2025 seront des médicaments de thérapie génique. L’industrialisation de la production de ces médicaments de thérapie innovante constitue un des enjeux majeurs de la médecine. Le marché des CDMOs spécialisées dans ce domaine s’est considérablement complexifié ces dernières années, au travers d’investissements massifs dans de nouvelles capacités de production ou d’acquisition d’unités existantes. Les leaders du marché sont localisés essentiellement aux États-Unis, mais il est important pour l’Europe, dont la France, de développer des capacités suffisantes pour assurer les productions futures de ces nouveaux biomédicaments. L’exemple d’Yposkesi, premier acteur français, est présenté dans cet article.
Les défis de la tarification des biothérapies
Authors: Bouyoux Philippe , Sales Jean-Patrick
Published: November 2023

Sous l’angle de la tarification, le marché des biothérapies recouvre aujourd’hui plusieurs situations et débats distincts. Un flux d’innovations onéreuses. Parmi les biothérapies présentes depuis plusieurs années, certaines ont conquis le marché dans des indications à large population, notamment dans les champs du diabète, de l’asthme, en cancérologie et dans les pathologies inflammatoires articulaires, digestives ou cutanées. Parmi les plus récentes, les thérapies géniques revendiquent des tarifs extrêmement élevés du fait d’un modèle économique bien spécifique lié au traitement par administration unique. La progression induite de la dépense interroge le mode de tarification, face à des laboratoires qui adaptent leur stratégie aux caractéristiques des biothérapies. La régulation dans le temps de ces produits via des baisses de prix justifiées par des extensions d’indications, et une concurrence entre acteurs. L’arrivée de biosimilaires. Depuis 2016, celle-ci accompagne le vieillissement de la classe des biothérapies et soulève la question de l’analogie – complète ou pas ? – avec les génériques.
Characterizations of ball-covering of separable Banach space and application
Authors: Shang Shaoqiang
Published: November 2023

In this paper, we first prove that the space $ (X, \|\cdot\|) $ is separable if and only if for every $ \varepsilon\in $ $ (0, 1) $, there is a dense subset $ G $ of $ X^{*} $ and a $ w^{*} $-lower semicontinuous norm $ \|\cdot\|_{0} $ of $ X^{*} $ so that (1) the norm $ \|\cdot\|_{0} $ is Frechet differentiable at every point of $ G $ and $ d_{F}\|x^{*}\|_{0}\in X $ is a $ w^{*} $-strongly exposed point of $ B(X^{**}, \|\cdot\|_{0}) $ whenever $ x^{*}\in G $; (2) $ \left(1+\varepsilon^{2}\right) {\left\| {{x^{***}}} \right\|_0} \le \left\| {{x^{***}}} \right\| \le \left(1 + \varepsilon \right){\left\| {{x^{***}}} \right\|_0} $ for each $ x^{***}\in X^{***} $; (3) there exists $ \{x_{i}^{*}\}_{i = 1}^{\infty}\subset G $ such that ball-covering $ \{ B({x_{i}^{*}}, {r_i})\} _{i = 1}^\infty $ of $ (X^{*}, \|\cdot\|_{0}) $ is $ (1+\varepsilon)^{-1} $-off the origin and $ S(X^{*}, \|\cdot\|)\subset \cup_{i = 1}^{\infty}B({x_{i}^{*}}, {r_i}) $. Moreover, we also prove that if space $ X $ is weakly locally uniform convex, then the space $ X $ is separable if and only if $ X^{*} $ has the ball-covering property. As an application, we get that Orlicz sequence space $ l_{M} $ has the ball-covering property.
New entanglement-assisted quantum codes constructed from Hermitian LCD codes
Authors: Ren Yuezhen , Li Ruihu , Guo Guanmin
Published: November 2023

Hermitian linear complementary dual (LCD) codes are a class of linear codes that intersect with their Hermitian dual trivially. Each Hermitian LCD code can give an entanglement-assisted quantum error-correcting code (EAQECC) with maximal entanglement. Methods of constructing Hermitian LCD codes from known codes were developed, and seven new Hermitian LCD codes with parameters $ [119,4,88]_{4} $, $ [123,4,91]_{4} $, $ [124,4,92]_{4} $, $ [136,4,101]_{4} $, $ [140,4,104]_{4} $, $ [188,4,140]_{4} $ and $ [212,4,158]_{4} $ were constructed. Seven families of Hermitian LCD codes and their related EAQECCs were derived from these codes. These new EAQECCs have better parameters than those known in the literature.
La guerra, «un torrent de paraules». Catàstrofe i guerra civil en la novel·lística de Miquel Àngel Riera
Authors: Dasca Maria
Published: November 2023

L’objectif de cette étude est d’analyser la représentation fictionnelle de la guerre d’Espagne, vue comme catastrophe, dans les romans Morir quan cal (1974) et L’endemà de mai (1978) de l’écrivain majorquin Miquel Àngel Riera. L’analyse portera sur les éléments de la représentation qui peuvent s’associer au caractère inénarrable de l’expression de la violence. Le motif de la guerre y sera abordé par l’analyse des techniques discursives et du traitement symbolique.
Memórias da catástrofe em Fim de Império de António Vieira
Authors: Araújo da Silva Maria
Published: November 2023

Ayant pour toile de fond la Guerre coloniale en Afrique lusophone, le roman Fim de Império (2008) de António Vieira plonge dans un passé de violences et de ruines que nous tâcherons ici de dévoiler.
(Sobre)viver no Estado Novo
Authors: Ferreira Adão Ana
Published: November 2023

Quoique fréquemment oublié parmi d’autres régimes dictatoriaux, le Salazarisme a été la plus longue dictature du XXe siècle, ayant duré de 1926 à 1974. En 1948, vingt-deux ans après le Coup d’État qui instaure l’État Nouveau Salazariste et trente ans après les débuts du Surréalisme d’André Breton, Alexandre O’Neill et d’autres poètes créent le Mouvement Surréaliste de Lisbonne. La censure et la répression salazaristes motivent une production littéraire de subversion, où la poésie serait l’espace de création d’une nouvelle vie, venant contredire la triste réalité imposée par ce régime. L’œuvre o’neillienne semble se servir de cet espace créatif, sur le réel, pour sur-vivre à l’État Nouveau et faire face à l’une des périodes les plus noires et catastrophiques de l’Histoire Européenne.
E a Noite passou a ser de trevas: a Sida como catástrofe
Authors: Curopos Fernando
Published: November 2023

Avec la Révolution des Œillets du 25 avril 1974, les homosexuels/les portugais sortent définitivement du placard, déjà entrouvert durant la Primavera Marcelista. Ils réinvestissent certains quartiers de Lisbonne et vont donner naissance à un semblant de Movida à la Portugaise, a Noite dans sa version lusitanienne. Néanmoins, l’insouciance est de courte durée, et l’apparition du VIH en 1981 plonge dans les ténèbres la Nuit portugaise. Le critique Eduardo Pitta affirme que « trinta anos passados sobre a descoberta do VIH, [...] é revelador que a representação da SIDA na literatura portuguesa seja praticamente nula ». Ce commentaire oblitère le rôle central du poète (et critique) Joaquim Manuel Magalhães à ce sujet, notamment son recueil A Poeira levada pelo vento (1993), qui s’inscrit clairement et en synchronie dans la « littérature du SIDA », témoignant ainsi de la « catastrophe ».
Ecos de la «segona naixença» de Joan Brossa: guerra i creació poètica
Authors: Audí Marc
Published: November 2023

L’œuvre poétique de Joan Brossa, de son propre aveu, est née d’une expérience personnelle durant la Guerre d’Espagne. Le poète y a été blessé à l’œil, dans des circonstances qu’il a narrées à de nombreuses reprises. Cet article est une exploration du poème le plus explicitement lié à cette expérience initiale, «La bataille du Segre ou la deuxième naissance», de 1950. Au-delà de l’analyse stylistique et thématique, il vise à fournir des pistes pour l’exploration de l’œuvre littéraire des années 1950, dans Ball de sang et Poesia rasa principalement.
A gestão do abismo na literatura brasileira recente: a iminência do desastre em Bernardo Carvalho
Authors: Thomaz Paulo César
Published: November 2023

Cette étude se propose d’analyser dans l’œuvre de l'écrivain brésilien Bernardo Carvalho des sujets qui illustrent une approche problématique entre l’écrit fictionnel et l’expérience existentielle caractérisée par une continuelle menace et le danger de destruction. À travers une forme fragmentaire, Carvalho revendique un imaginaire catastrophique qui dialogue avec le désastre. Ainsi, il apporte à la littérature les déchirements et les déséquilibres des liens furtifs entre la matérialité et l’historicité du présent.
«Tensho»: un poema de Carles Duarte després de Fukushima
Authors: Güell Mònica
Published: November 2023

Dans le poème «Tensho» (d’Alba del vespre), écrit un an après la catastrophe de Fukushima, Carles Duarte offre une réflexion personnelle sur la condition humaine. Notre analyse portera sur le jeu de l’énonciation, les images duartiennes, la métrique et la réflexion poétique inspirée par les philosophes grecs.
Le vertige futurologique
Authors: Grimaud Emmanuel , Wacquez Julien
Published: November 2023

Après une reprise critique de l’histoire de la futurologie comme discipline, ce texte propose plusieurs pistes de recherche pour aborder l’activité spéculative en général et le travail d’anticipation des futurologues en particulier. Il en appelle à la constitution d’une science des vertiges ou vertigologie, et examine les manières les plus courantes de se projeter dans un futur vertigineux, de la fin de l’humanité jusqu’au changement d’échelle.
Au pays des murs-vivants
Authors: Salme Juliette
Published: November 2023

À partir d’une enquête ethnographique réalisée auprès d’architectes membres d’un laboratoire de mycologie amateur en Belgique, cet article porte sur les manières dont la question du futur se donne constamment à voir dans leurs pratiques de fabrication de matériaux alternatifs élaborés à partir de mycélium de champignon. Cette contribution décrit comment, pendant et en amont de moments de valuation, ce collectif cherche à rendre présent à la fois discursivement et matériellement différentes versions de l’avenir, dans lesquelles l’intégration des champignons au domaine de la construction est rendue acceptable.
Jusqu’au bout de l’humain
Authors: Tabas Brad
Published: November 2023

Cet article présente une critique des revendications éthiques qui sous-tendent ce qu’il appelle le nouveau futurisme. L’auteur suggère (sans établir ni nier la possibilité de tels cas) que tout argument légitime en faveur de l’expansion de l’habitat humain au-delà de la planète devrait rester humain, c’est-à-dire qu’il devrait montrer la valeur éthique de l’expansion au-delà de la Terre en termes de qualité de vie qu’elle pourrait offrir à un nombre fini d’êtres qui vivent eux-mêmes le type de vie limitée et écologiquement vulnérable que nous vivons aujourd’hui sur la planète Terre.
Du lard bleu dans le cerveau
Authors: Scagliusi Domenico
Published: November 2023

Cet article a pour but d’illustrer le désarroi historique produit par l’effondrement de l’Union soviétique à travers l’une de ses représentations littéraires les plus saisissantes : le roman de Vladimir Sorokin Le Lard bleu (1999). Cette étude se propose d’identifier les termes dans lesquels le roman retranscrit le sentiment d’un ébranlement du cours du temps, à travers l’analyse des procédés narratifs qui concourent à la réalisation d’un motif typique de la science-fiction : le voyage dans le temps. Nous reconnaîtrons dans ces distorsions temporelles la difficulté à replacer les événements du xxe siècle dans une histoire linéaire et à attribuer un sens au devenir historique.
Quatre nuances de sino-futurisme
Authors: Gaffric Gwennaël
Published: November 2023

At a time when China is establishing itself, economically and geopolitically, as the “nation of tomorrow”, how can we understand the production of “sinofuturist” discourses and imaginary representations, taking into account the heterogeneous interpretations of this concept? This article examines four different ways of projecting a “Chinese” future: “Sinofuturism and techno-orientalism”; “Sinofuturism and post-orientalism”; “Sinofuturism and state futurism”; and “Sinofuturism without China”. This study enables us to show how these often contradictory and conflicting discourses nevertheless overlap in a form of denial of what Johannes Fabian calls “co-temporality”.
Welcome to la banlieue du TURFU
Authors: Fofana Makan
Published: November 2023

Cet article décrit la naissance d’un uni- vers littéraire qui sert à transformer les imaginaires sociaux à travers des ateliers participatifs du TURFU. L’auteur nous raconte, l’émergence du projet et le déroulement d’un atelier type.
Framing Our Understanding of Mathematical Writing
Authors: Casa Tutita M. , Cardetti Fabiana , Colonnese Madelyn W.
Published: November 2023

In this chapter, the authors situate mathematical writing within the context of discourse, define mathematical writing, describe the classroom environment that fosters mathematical writing, and share experiences engaging elementary students in mathematical writing. At their core, the types of mathematical writing are defined by the purposes for which students write in the mathematics classroom. The authors further describe the types of mathematical writing teachers prompt and are nurtured by the classroom environment. The insights shared draw from the authors' previous and current research endeavors, advancements in curriculum development, collaborations with mathematics coaches, and experiences teaching elementary students and supporting preservice and inservice teachers. They end the chapter by highlighting some directions for future research to expand our understanding of this crucial area in mathematics education.
Dialogically Focused Secondary Mathematics Teachers' Orientations Toward Mathematical Writing
Authors: Smith Ethan P.
Published: November 2023

Because mathematics classrooms entail expectations for students to communicate understanding through both writing and spoken discourse, it is important to consider the place of writing in the context of such discourse. This chapter details a case study centered around three dialogically focused high school mathematics teachers and their orientations toward mathematical writing. Teachers in this study were first asked to describe their orientations toward mathematical writing. Then, they were asked to reflect on samples of student writing and recordings from their classrooms to further understand how they orient toward students' mathematical writing. Findings suggested that these teachers' orientations toward mathematical writing are embedded in broader views that they hold toward discourse, feedback, and student and teacher self-efficacy around writing. Findings also indicated the value of using the construct of teacher noticing to help investigate and strengthen teachers' orientations toward mathematical writing.
Assessing Mathematical Writing
Authors: Jones Ian , Hunter Jodie
Published: November 2023

The chapter discusses potential professional learning benefits for educators who engage in assessing students' mathematical writing. It draws on interview data from twelve mathematics educators who were experienced in assessing primary students' written responses to free response prompts covering a range of topics. The first stage of the interviews used a stimulated recall protocol that followed a comparative judgment procedure in which each participant was presented with pairs of students' written responses and asked to decide which was ‘better'. The second stage was semi-structured with questions about how participants made their comparative judgment decisions, and whether doing so improved their understanding of students' thinking. The findings are that assessing mathematical writing can provide educators with insights into students' representations, underlying ideas and learning trajectories, and can also provide stimulus for changing classroom practice.
A Mathematics Intervention to Engage Elementary Students in Mathematical Writing
Authors: Colonnese Madelyn W. , Cardetti Fabiana
Published: November 2023

Mathematical writing is an important yet underutilized mode of discourse. Teachers play an important role in implementing and engaging their students' mathematical writing. However, research on mathematical writing does not offer suggestions for how teachers can engage students in mathematical writing. The purpose of this chapter is to contribute to this area of research by describing how teachers implemented a systematic mathematical writing intervention during a summer school program. The student writing resulting from the intervention demonstrated that students can successfully engage in mathematical writing. Further, students' written work showed key elements of mathematical writing and indicated an understanding of the subconstructs of fraction conceptualization that appeared to be absent prior to the intervention.
What to Assess for Mathematical Writing
Authors: Lee Joo-Young , Hughes Elizabeth M. , Riccomini Paul J.
Published: November 2023

This chapter investigates the internal structure of informative/explanatory mathematical writing (MW) as a latent variable. The study defines it as written communication in mathematics to explain and describe one's problem solving and reasoning by using mathematical language and representation. To assess the dimensions of MW, ten scales were developed based on literature and expert reviews to quantify students' MW performance. The dataset utilized for statistical analyses consisted of MW samples from 153 4th-grade students attending a public school in a Mid-Atlantic state. Through exploratory factor analysis (EFA) conducted on the three MW prompts, two factors emerged: mathematics problem solving and reasoning and writing. Subsequently, a confirmatory factor analysis (CFA) was conducted, resulting in a cross-factor loading of reasoning onto both factors. The role of representations in MW remains uncertain. This finding contributes to an understanding of the underlying dimensions, as well as offers a validated approach for assessing MW.
Academic Literacy in Mathematics to Frame Mathematical Writing Research and Practice
Authors: Moschkovich Judit N.
Published: November 2023

Oral student contributions are important for learning mathematics, but without a written record of students' reasoning, revising is difficult or impossible. While writing makes revising possible, research needs to theoretically frame what to revise, how to revise, and how to support revisions. The chapter addresses the question: How can the academic literacy in mathematics framework inform research and practice on mathematical writing? The examples illustrate how that framework provides a complex view of language and a focus on mathematical practices to frame research and practice on mathematical writing and revising. The chapter considers why student writing and revising are important and describes how both research and instruction can emphasize mathematical practices. The examples focus on explanatory and argumentative writing and several mathematical practices central to revising explanations or arguments: generating conjectures, connecting representations, justifying claims, constructing arguments, and attending to precision.
A Call to All Political Educators
Authors: Segura Pamela
Published: November 2023

The contexts within which social justice-minded public school teachers (SJST) work in the United States have always been replete with harm and healing. This is because SJST see their role as vital to the work of shifting localized material realities as well as engaging broader movements to bring about liberation, democracy, and radical reimagination. 2023 has certainly continued this dialectic: several bans on education are targeting marginalized communities. What impact does this have on SJST, who already have a complicated and passionate relationship with their calling as educators? How can comrades and accomplices outside of the institution respond to this impact? Because of its position outside of the K-12 institution, the identity and role of a political educator has allowed me to co-create spaces of home, hope, and healing for SJST that can strengthen responses in this hostile educational context. Implications of this work are discussed.
Being Nepantleras While Resisting “Everything, Every Where, All at Once”
Authors: Nix-Stevenson Dara N.
Published: November 2023

As the idea of trauma-informed education has moved to the center of many conversations in PK-12 education, it demands that PK-12 professionals seek to act as Nepantleras in navigating pervasive deficit perspectives in schooling, like book banning censorship and erasure, to counter the ways trauma feeds false narratives of damage and brokenness about students. Under this neoliberalist project, in this chapter, the author seeks to explore how this body of knowledge and their value are produced and thus policed and assigned value. To combat this, the author invokes Gloria Anzaldúa's philosophical concepts of the Nepantla, specifically the Nepantleras. The author explores how Governor Ron DeSantis of Florida has positioned himself as the avatar of white grievance politics to resist any culturally responsive/relevant/sustaining pedagogy taught in PK-12 schools with a specific counternarrative focus on the experience of teaching Amanda Gorman's poem “The Hill We Climb” in the author's seventh/eight grade classroom.
Obras e “reminiscências médicas” de Pedro Nava
Authors: Gabriel Maria Alice Ribeiro
Published: November 2023

Muitos estudiosos têm destacado a riqueza das Memórias e escritos de Pedro Nava sobre medicina como sendo culturalmente importantes, assinalando a complexidade das posturas narrativas adotadas pelo memorialista brasileiro. Descrevendo aspectos da prosa histórica e literária utilizada pelo autor, este estudo discute como Pedro Nava fez uso de um paradigma epistemológico para expressar sua visão sobre a medicina em seus escritos como historiador da medicina e memorialista.
Tradição e modernidade no Brasil: o conservadorismo culturalista de Gilberto Freyre
Authors: Gileno Carlos Henrique , Medeiros Rodrigo Dantas de
Published: November 2023

O objetivo deste artigo é contribuir para análises acadêmicas futuras sobre o conservadorismo culturalista inscrito na trajetória intelectual do pernambucano Gilberto de Mello Freyre (1900-1987). O conservadorismo culturalista é uma das linhagens conservadoras constantes no pensamento político e social no Brasil do passado e do presente. Metodologicamente, descrevemos as heranças intelectuais europeia e norte-americana que influenciaram o pensamento freyreano. Aquele conservadorismo teve a sua gênese nos autores britânicos vitorianos, com os quais Gilberto Freyre manteve contato durante a mocidade nos Estados Unidos e na Europa, notadamente na Universidade de Oxford.

Palavras-chave: Gilberto Freyre; conservadorismo culturalista; tradição; modernidade; pensamento político e social no Brasil.
Decolonialidad planetaria – teoría de la complejidad: entramado apodíctico de la liberación, ¿y la antropofagia?
Authors: Rodríguez Milagros Elena
Published: November 2023

En la indagación rizomática transmetódica con el transparadigma complejo, y el transmétodo la deconstrucción rizomática se analiza la decolonialidad planetaria - teoría de la complejidad como apodícticas de la liberación, ¿y la antropofagia? En la reconstruccion se liberan esencias onto-epiestemologicas ocultadas en la colonialidad como es el reduccionismo, la opresión del sujeto investigador y demas prohibiciones que desvirtuarón y maquinarizarón nuestra manera de vivir en la Tierra; que se camuflajean en la decolonialidad. La teoría de la complejidad no es anti-analítica, no es antidisyuntiva. Exclusiones que no podemos cometer. Abrazamos la liberación en todo sentido en el planeta.
Melancolia na metrópole à beira mar: um esboço sobre modernismos queer no Brasil
Authors: Marconi Dieison
Published: November 2023

O artigo propõe uma reflexão inicial sobre modernismos queer no Brasil, mais especificamente, nos cenários culturais, intelectuais e artísticos da cidade do Rio de Janeiro (RJ) que ganharam corpo a partir dos anos 1920. Em sua primeira parte, o texto apresenta uma revisão crítica de um conjunto de estudos norte-americanos e europeus sobre modernismos e modernismos queer que foram produzidos a partir dos anos 1990. Em um segundo momento, o artigo se detém em conectar de maneira preambular a vida e a obra de artistas como Lúcio Cardoso, Mário Peixoto, Alberto Cavalcanti e Farnese de Andrade, quatro artistas de gênero e/ou sexualidades dissidentes que viveram e/ou passaram pela capital fluminense e que poderiam, mais do que serem estudados de forma isolada, serem constelados enquanto um conjunto de modernistas queer que ficaram à margem do cânone do modernismo brasileiro. Desse modo, o artigo se apresenta como uma primeira tentativa de suprir uma carência de estudos a respeito dos laços entre estudos queer e modernismos no Brasil, sobretudo ampliar a estreita bibliografia a respeito das possíveis sensibilidades articuladoras de problemas éticos e estéticos dos modernismos queer.
Poéticas do Mangue – o tom e o traço: um diálogo entre Brancura e Lasar Segall
Authors: Garcia Nunes Lucas , Da Silva Gabral Gladir
Published: November 2023

Este artigo propõe uma interlocução entre dois sambas de Sylvio Fernandes Lima, conhecido como Brancura, do Estácio de Sá, e duas gravuras do artista plástico Lasar Segall, tomando como referência espacial a famosa Zona do Mangue, no Rio de Janeiro da década de 1920. Os artefatos artístico-culturais são analisados a partir da noção de colonialidade do poder e de resistência ao poder por meio da arte exemplificada pelos sambas de Brancura e pelas gravuras de Lasar Segall. O conceito de decolonialidade, conforme apresenta Anibal Quijano (2005), servirá de referência teórica em articulação com as noções de branquitude, resistência e malandragem.
Establishment of CD8+ T Cell Thymic Central Tolerance to Tissue-Restricted Antigen Requires PD-1
Authors: May Julia F , Kelly Rees G , Suen Alexander Y W , Kim Jeongbee , Kim Jeongwoo , Anderson Colin C , Rayat Gina R , Baldwin Troy A
Published: November 2023

Highly self-reactive T cells are censored from the repertoire by both central and peripheral tolerance mechanisms upon receipt of high-affinity TCR signals. Clonal deletion is considered a major driver of central tolerance; however, other mechanisms such as induction of regulatory T cells and functional impairment have been described. An understanding of the interplay between these different central tolerance mechanisms is still lacking. We previously showed that impaired clonal deletion to a model tissue-restricted Ag did not compromise tolerance. In this study, we determined that murine T cells that failed clonal deletion were rendered functionally impaired in the thymus. Programmed cell death protein 1 (PD-1) was induced in the thymus and was required to establish cell-intrinsic tolerance to tissue-restricted Ag in CD8+ thymocytes independently of clonal deletion. In bone marrow chimeras, tolerance was not observed in PD-L1–deficient recipients, but tolerance was largely maintained following adoptive transfer of tolerant thymocytes or T cells to PD-L1–deficient recipients. However, CRISPR-mediated ablation of PD-1 in tolerant T cells resulted in broken tolerance, suggesting different PD-1 signaling requirements for establishing versus maintaining tolerance. Finally, we showed that chronic exposure to high-affinity Ag supported the long-term maintenance of tolerance. Taken together, our study identifies a critical role for PD-1 in establishing central tolerance in autoreactive T cells that escape clonal deletion. It also sheds light on potential mechanisms of action of anti–PD-1 pathway immune checkpoint blockade and the development of immune-related adverse events.
Enhancers within the Ig V Gene Region Orchestrate Chromatin Topology and Regulate V Gene Rearrangement Frequency to Shape the B Cell Receptor Repertoire Specificities
Authors: Barajas-Mora E Mauricio , Feeney Ann J
Published: November 2023

Effective Ab-mediated responses depend on a highly diverse Ab repertoire with the ability to bind a wide range of epitopes in disease-causing agents. The generation of this repertoire depends on the somatic recombination of the variable (V), diversity (D), and joining (J) genes in the Ig loci of developing B cells. It has been known for some time that individual V, D, and J gene segments rearrange at different frequencies, but the mechanisms behind this unequal V gene usage have not been well understood. However, recent work has revealed that newly described enhancers scattered throughout the V gene–containing portion of the Ig loci regulate the V gene recombination frequency in a regional manner. Deletion of three of these enhancers revealed that these elements exert many layers of control during V(D)J recombination, including long-range chromatin interactions, epigenetic milieu, chromatin accessibility, and compartmentalization.
Assessment of phosphorus behavior in sediments of Lake Sevan, Armenia
Authors: Dadi Tallent , Von Tümpling Wolf , Mi Chenxi , Schultze Martin , Friese Kurt
Published: November 2023

Lake Sevan is the largest freshwater lake in the Caucasus region and one of Eurasia's largest alpine lakes. The lake has been experiencing growing cyanobacteria blooms; however, the relevance of external and internal phosphorus (P) loading to its eutrophication is still not known. We carried out a sediment investigation of Lake Sevan to estimate the potentially mobile P, which could be a source of internal total phosphorus (TP)-loading; we also estimated external TP-loading and retention. The study was carried out at four sampling points of different depths to determine the spatial variability of P in 2018. The sediments had elevated TP contents at the sediment surface; potentially mobile P ranged from 20 to 60% in the top 2 cm. The upper 4 cm sediment had an elevated content of TN (8 to 16.1 mg N g-1 dw) and TP (1.2 to 1.7 mg P g-1 dw). Spatial variability of most of the measured parameters was more prominent in the upper 3 cm. External TP loading was estimated to be 110 tons annually, and the TP retention was 85%. The estimated TP stored in the top cm of the sediment is 1,500 tons. The potential for P release is high; the short-term exchange between oxic and anoxic overlying water could release 0.01 to 0.02 mg P L-1 from the top cm of the sediment, and long-term diagenesis and burial could release about 0.12 mg P cm-2. Internal P-loading in Lake Sevan may play an essential role in eutrophication, especially given the long flushing time of Lake Sevan.
Correlation between Phragmites australis growth and seasonal lake level variations in Lake Maggiore (Italy/Switzerland): common reed management guidelines
Authors: Elzi Lisa , Villa Edoardo , Patocchi Nicola
Published: November 2023

The present study investigates the impact of water level regulation on the growth of common reed (Phragmites australis), a globally widespread helophytic plant. The investigation has been carried out in the Bolle di Magadino (municipalities of Locarno, Gambarogno, Gordola and Tenero; Ticino, Switzerland), a lacustrine-riparian nature reserve in the context of the Lake Maggiore (that stretches between Italy and Switzerland). This is an oligotrophic, artificially regulated lake. Our initial hypothesis was that variation in water table regulation is the most influential factor for explaining observed local reed dieback. To test this, culm height of P. australis was measured at each significant change in lake water level (water table height increase greater than 20 cm), or monthly in the case of a relatively constant lake level. The study took place between 2020 and 2022, monitoring 14 plots of 400 m2, placed at three different relative elevation classes with respect to the level of the lake (5 plots at low elevation, <193.475 m; 7 plots at intermediate elevation, 193.476-193.700 m; 2 plots at high elevation, >193.701 m). The results showed that P. australis growth is significantly influenced by the lake water level and thus the relative elevation of the stands, with lower lake levels leading to better growth, especially during the early phases of the growing season. On the other hand, prolonged flooding of shoots significantly impaired common reed growth. The study identifies two relevant relative elevation thresholds for winter mowing, a management practice that enhances reedbeds health. Mowing below 193.20 m elevation is considered risky, as no healthy reedbeds have been observed below this threshold. Mowing below an elevation of 193.50 m was defined as possibly risky, due to observed dieback in some areas as well as healthy reedbeds in other locations at the same or lower elevations. The research also discussed the potential impact of future changes in water level regulation, including the planned change in the spring regulation threshold (+1.50 m above the hydrometric zero in Sesto Calende). This is expected to result in a further rearrangement in lacustrine vegetation, with the growth optimum for P. australis becoming higher and an increase in clumping habit. In conclusion, this study provides valuable insights into the impact of water level regulation on the growth of P. australis in the Bolle di Magadino nature reserve. The research highlights the need for careful management of water level regulation to preserve the reedbed ecosystem and identifies relevant elevation thresholds for winter mowing to mitigate the risks of reed dieback. The findings can inform future management strategies for the Bolle di Magadino reserve and other similar ecosystems facing the challenges of artificial regulation of water levels.
The prevalence of Atribacteria affiliated with JS1 in the sediment core of Lake Sayram, the largest alpine lake, China
Authors: Shao Keqiang , Ba Tunasheng , Qin Boqiang , Chao Jianying , Gao Guang
Published: November 2023

Atribacteria play an important role in global carbon cycling. Little is known, however, about the Atribacteria communities found inalpine lakes. The presence and diversity of Atribacteria in the sediment core of alpine Sayram lake in China were investigated usingIllumina MiSeq sequencing in this study. According to the findings, Atribacteria affiliated with JS1 were dominant in the sediment coreof Sayram Lake, with a relative abundance of 0.19 to 10% (average 3.75%) of all bacterial sequences. Furthermore, the relativeabundance of Atribacteria associated with JS1 increased with sediment depth. As a result, this study significantly contributes to ourunderstanding of Atribacteria community habitat.
The New Africa Digital Health Deal
Authors: Nsengimana Jean-Philbert , Kaseya Jean
Published: November 2023

No abstract available.
Association of SLC22A1, SLC47A1, and KCNJ11 polymorphisms with efficacy and safety of metformin and sulfonylurea combination therapy in Egyptian patients with type 2 diabetes
Authors: Ahmed Aya , Elsadek Hany M. , Shalaby Sally M. , Elnahas Hanan M.
Published: November 2023

Background and purpose:

Multidrug and toxin extrusion transporter 1 (MATE1), encoded by the SLC47A1 gene and single nucleotide polymorphisms of organic cation transport 1, may impact metformin's responsiveness and side effects. Inward-rectifier potassium channel 6.2 (Kir 6.2) subunits encoded by KCNJ11 may affect the response to sulfonylurea. This study aimed to evaluate the association between SLC22A1 rs72552763 and rs628031, SLC47A1 rs2289669 and KCNJ11 rs5219 genetic variations with sulfonylurea and metformin combination therapy efficacy and safety in Egyptian type 2 diabetes mellitus patients.

Experimental approach:

This study was conducted on 100 cases taking at least one year of sulfonylurea and metformin combination therapy. Patients were genotyped via the polymerase chain reaction-restriction fragment length polymorphism technique. Then, according to their glycated hemoglobin level, cases were subdivided into non-responders or responders. Depending on metformin-induced gastrointestinal tract side effects incidence, patients are classified as tolerant or intolerant.

Findings/Results:

KCNJ11 rs5219 heterozygous and homozygous mutant genotypes, SLC47A1 rs2289669 heterozygous and homozygous mutant genotypes (AA and AG), and mutant alleles of both polymorphisms were significantly related with increased response to combined therapy. Individuals with the SLC22A1 (rs72552763) GAT/del genotype and the SLC22A1 (rs628031) AG and AA genotypes were at a higher risk for metformin-induced gastrointestinal tract adverse effects.

Conclusion and implications:

The results implied a role for SLC47A1 rs2289669 and KCNJ11 rs5219 in the responsiveness to combined therapy. SLC22A1 (rs628031) and (rs72552763) polymorphisms may be associated with increased metformin adverse effects in type 2 diabetes mellitus patients.
Long-term outcomes of endovascular treatment of acute lower limb deep-vein thrombosis combined with May–Thurner syndrome: A single-center retrospective cohort study
Authors: Pang Yunfeng , Li Kailong , Li Xiaoqin , Jin Yang , Cai Hao , Shao Fei , Wang Guodong , Ma Chong , Wen Gehua , Sun Ziqiang , Jin Song
Published: November 2023

OBJECTIVE:

May–Thurner syndrome (MTS) is a common cause of lower-extremity deep venous thrombosis (DVT). Stenting is effective in the treatment of MTS; however, there are still complications that may affect the patency of the stent. In addition, the long-term efficacy of stenting remains uncertain. This retrospective study investigated the efficacy and prognosis of endovascular treatment of acute proximal DVT with MTS.

MATERIALS AND METHODS:

Between June 2014 and December 2017, 122 patients with acute symptomatic proximal DVT at our hospital underwent endovascular surgery. The clinical data of the patients were retrospectively collected including follow-up information. The analysis used the generalized additive mixed model and Kaplan–Meier curves (log-rank test).

RESULTS:

Of the 122 patients, 75 underwent only catheter-directed thrombolysis (CDT), and 47 underwent CDT with stent placement. Characteristics such as age (P = 0.630 ) and gender (P = 0.842) did not show significant differences between the two groups. The freedom from target lesion revascularization did not show significant differences between the two groups (P = 0.82). There were no significant differences between the two groups in the Venous Clinical Severity Score and Villalta Score.

CONCLUSIONS:

Endovascular treatment of acute lower limb DVT with MTS has good overall efficacy. In young patients with DVT caused by multiple factors besides MTS, prolonged anticoagulation and close follow-up may be more appropriate than primary stenting after thrombus clearance and significant relief of lower limb symptoms.
A retrospective study of endovascular repair of aortic dissection with aberrant right subclavian artery
Authors: Liu Yunchong , Wu Weibin , Wu Ridong , Wang Mian , Chang Guangqi , Yao Chen , Li Zilun
Published: November 2023

OBJECTIVES:

Aortic dissection with aberrant right subclavian artery (ARSA) is rare but fatal, with its optimal treatment remaining controversial. In this retrospective study, we presented the outcome of endovascular repair for these patients, aiming to evaluate the efficacy and safety of this technique.

MATERIALS AND METHODS:

From January 2016 to January 2022, seven patients diagnosed with aortic dissection with ARSA in the First Affiliated Hospital of Sun Yat-sen University were enrolled. All these seven patients received thoracic endovascular aortic repair (TEVAR) within 1 week after their admission to our center. The data of baseline characteristics, imaging parameters, perioperative information, and follow-up were collected till March 2023.

RESULTS:

The mean age was 48.57 ± 9.41 years. Kommerell diverticulum was found in 2 (28.6%) patients. Among these seven patients, 4 (57.1%) were treated by TEVAR + branched stent graft + chimney technique, 2 (28.6%) were treated by TEVAR + chimney technique, and 1 (14.3%) was treated by TEVAR + chimney and periscope techniques. The mean time of procedures was 196.67 ± 31.18 min. Clinical success was achieved in 6 (85.7%) patients, while 1 (14.3%) patient died of nonaortic related cause. Bird beak configuration was discovered in 4 (57.1%) patients with an average length of 17.87 ± 3.93 mm and angle of 21.9° ±3.70°. One early type I endoleak and one mild cerebral ischemia were discovered, and recovered spontaneously before discharge. The diameter of the aorta remained stable, and no complication was found during the follow-up of the six patients.

CONCLUSION:

Endovascular repair of aortic dissection with ARSA was feasible and safe, with a favorable early to mid-term outcome.
Esophageal stricture following repair of a tracheoesophageal fistula: A case report and literature review
Authors: Mukherjee Debarpito , Das Indranil , Saha Achyut , Halder Pankaj
Published: November 2023

Anastomotic stricture is a common complication following repair of esophageal atresia with or without tracheo-esophageal fistula, affecting the long-term prognosis of survival. The traditional therapy includes serial esophageal dilation or repeated anastomosis with or without a gastric pull-up procedure. Here, we describe the case of an 11-month-old girl child who underwent repair of type C esophageal atresia but afterward experienced esophageal anastomotic stricture. In the event that the dilatations failed, the esophageal anastomosis had to be revised. Despite repeated corrective surgeries and extensive perioperative care, we were unable to save the child.
Sclerosing Variant of Adenoid Cystic Carcinoma - A Case Report on the Role of Sclerosis in the Prognostic Outcome
Authors: Krishnan Reshma Poothakulath , Pandiar Deepak , Ramani Pratibha
Published: November 2023

Rationale:

Sclerosing variant of adenoid cystic carcinoma (SACC) is a rare variant of adenoid cystic carcinoma (ACC) with only two cases in the literature. In this article, we report two cases of SACCs and attempt to explain the reason for sclerosis and its association with the disease outcome.

Patient Concerns:

The first patient is a 43-year-old Dravidian Indian female with a chief complaint of pain and swelling in the right posterior cheek region of four months’ duration. The second patient is an 8-year-old boy with a well-defined swelling in the left cheek region.

Diagnosis:

Both these cases were diagnosed as sclerosing variants of ACC.

Treatment:

The tumour was surgically excised for both patients.

Outcomes:

Both the patients had no signs of residual disease/recurrence.

Take-away Lessons:

We opine that the dense sclerotic stroma may have a preventing role in tumour cell growth and progression.
A Middle-aged Female Getting Longstanding Levothyroxine Ultimately Diagnosed as Thyroid-stimulating Hormone-producing Adenoma – Case Report from Bangladesh
Authors: Hasan Md. Rakibul
Published: November 2023

The thyroid-stimulating hormone-producing adenoma is a very rare cause of thyrotoxicosis with a prevalence in the general population is 1–2 cases per million. We are reporting a 41-year-old female referred by a nephrologist to the endocrinology outpatient department due to nonsuppressed thyroid-stimulating hormone (TSH) with a high dose (100 μg/day) of oral levothyroxine replacement. Serum FT4 and FT3 were very high at that time and the patient was clinically thyrotoxic. She had good compliance with medicine. Magnetic resonance imaging of the Sella and Parasellar region with contrast revealed a pituitary macroadenoma. Other hormones of the pituitary gland were within normal range. We diagnosed this case as an isolated TSH-secreting pituitary adenoma and prepared for surgical intervention but the patient refused to undergo any operation and no follow-up since then. Finally, the patient died in November 2022 due to thyrotoxicosis-related complications and chronic kidney disease.
Ophiopogonin D Improves Oxidative Stress and Mitochondrial Dysfunction in Pancreatic β Cells Induced by Hydrogen Peroxide through Keap1/Nrf2/ARE Pathway in Diabetes Mellitus
Authors: Zhang Hongyan , Kang Xuezhi , Ruan Jun , Ma Li , Peng Wenbo , Shang Haonan , Wang Bing , Sun Yongning
Published: November 2023

Diabetes mellitus (DM) is a metabolic disease characterized by high blood sugar. Due to its complex pathogenesis, no effective drugs have been found so far. Ophiopogonin D (OP-D) has anti-inflammatory, antioxidant, and anticancer activities, but its role in DM has not been studied so far. Hydrogen peroxide (H2O2) was used to induce INS-1 cells. INS-1 cells induced by H2O2 were treated with OP-D, and cell apoptosis, oxidative stress damage, and related indexes of mitochondrial function were respectively detected by cell counting kit-8, flow cytometry, western blot, enzyme-linked immunosorbent assay, real-time quantitative polymerase chain reaction, JC-1 fluorescent probe, and related kits. Subsequently, molecular docking techniques were used to investigate the relationship between OP-D and Keap1 and to explore the regulation mechanism of OP-D on H2O2-induced oxidative stress and mitochondrial function in INS-1 cells. OP-D inhibited the apoptosis and oxidative stress level of H2O2-induced INS-1 cells, thereby inhibiting cell damage. Moreover, OP-D inhibited mitochondrial dysfunction in H2O2-induced INS-1 cells. At last, we found that Keap1/Nrf2 specific signaling pathway inhibitor ML385 was able to reverse the inhibitory effect of OP-D on H2O2-induced oxidative stress and mitochondrial dysfunction in INS-1 cells. In conclusion, OP-D improves oxidative stress and mitochondrial dysfunction in pancreatic β cells induced by H2O2 through activating Keap1/Nrf2/ARE pathway in DM.