bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of snowfall on changes in relative seismic velocity measured by ambient noise correlation
Authors: Guillemot Antoine , van Herwijnen Alec , Larose Eric , Mayer Stephanie , Baillet Laurent
Published: May 2021

Abstract. In mountainous, cold temperate and polar sites, the presence of a snow cover can affect relative seismic velocity changes (dV/V) derived from ambient noise correlation, but this relation is relatively poorly documented and ambiguous. In this study, we analyzed raw seismic recordings from a snowy flat field site located above Davos (Switzerland), during one entire winter season (from December 2018 to June 2019). We identified three snowfall events with a substantial response of dV/V measurements (drops of several percent between 15 and 25 Hz), suggesting a detectable change in elastic properties of the medium due to the additional fresh snow. To better interpret the measurements, we used a physical model to compute frequency dependent changes in the Rayleigh wave velocity computed before and after the events. Elastic parameters of the ground subsurface were obtained from a seismic refraction survey, whereas snow cover properties were obtained from the snow cover model SNOWPACK. The decrease in dV/V due to a snowfall were well reproduced, with the same order of magnitude as observed values, confirming the importance of the effect of fresh and dry snow on seismic measurements. We also observed a decrease in dV/V with snowmelt periods, but we were not able to reproduce those changes with our model. Overall, our results highlight the effect of the snowcover on seismic measurements, but more work is needed to accurately model this response, in particular for the presence of liquid water in the snowpack.
Assessing Boundary Condition and Parametric Uncertainty in Numerical-Weather-Prediction-Modeled, Long-Term Offshore Wind Speed Through Machine Learning and Analog Ensemble
Authors: Bodini Nicola , Hu Weiming , Optis Mike , Cervone Guido , Alessandrini Stefano
Published: May 2021

Abstract. To accurately plan and manage wind power plants, not only does the time-varying wind resource at the site of interest need to be assessed, but also the uncertainty connected to this estimate. Numerical weather prediction (NWP) models at the mesoscale represent a valuable way to characterize the wind resource offshore, given the challenges connected with measuring hub height wind speed. The boundary condition and parametric uncertainty associated with modeled wind speed is often estimated by running a model ensemble. However, creating an NWP ensemble of long-term wind resource data over a large region represents a computational challenge. Here, we propose two approaches to temporally extrapolate wind speed boundary condition and parametric uncertainty using a more convenient setup where a mesoscale ensemble is run over a short-term period (1 year), and only a single model covers the desired long-term period (20 year). We quantify hub-height wind speed boundary condition and parametric uncertainty from the short-term model ensemble as its normalized across-ensemble standard deviation. Then, we develop and apply a gradient-boosting model and an analog ensemble approach to temporally extrapolate such uncertainty to the full 20-year period, where only a single model run is available. As a test case, we consider offshore wind resource characterization in the California Outer Continental Shelf. Both the proposed approaches provide accurate estimates of the long-term wind speed boundary condition and parametric uncertainty across the region (R2 > 0.75), with the gradient-boosting model slightly outperforming the analog ensemble in terms of bias and centered root-mean-square error. At the three offshore wind energy lease areas in the region, we find a long-term median hourly uncertainty between 10 % and 14 % of the mean hub-height wind speed values. Finally, we assess the physical variability of the uncertainty estimates. In general, we find that the wind speed uncertainty increases closer to land. Also, neutral conditions have smaller uncertainty than the stable and unstable cases, and the modeled wind speed in winter has less boundary condition and parametric sensitivity than summer.
Book Review: Older Women Who Work: Resilience, Choice, and Change
Authors: Bratun Urša
Published: May 2021

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Book Review: Elderly Care, Intergenerational Relationships and Social Change in Rural China
Authors: Ma Mengxing
Published: May 2021

n/a
Skills, Scalpels and Robots: The Surgeon as Technician
Authors: Del Fabbro Olivier , Muller Xavier
Published: May 2021

According to Aristotle, medical practice relies on practical knowledge to care for individual patients. This is especially true for surgery, where the surgeon directly acts on a patient using not only technical skills but also acquired experience. We first describe the surgeon’s technical activity, which is directly linked to surgical tools and their historical evolution. Second, given that surgical activity aims at treating patients, we analyze which techniques and concurrent knowledge the surgeon must rely on to perform successful surgical operations. These characteristics are analyzed by using concepts from philosophy of technologies by André Leroi-Gourhan, Gilbert Simondon and John Dewey.
Evaluation of the presence of AmpC (FOX) beta-lactamase gene in clinical strains of Escherichia coli isolated from hospitalized patients in Tabriz, Iran
Authors: SADEGHI DEYLAMDEH Zahra , JAFARI SALES Abolfazl
Published: May 2021

Beta-lactamases are the most common cause of bacterial resistance to beta-lactam antibiotics. AmpC-type beta-lactamases hydrolyze cephalosporins, penicillins, and cephamycins. Therefore, the study aims was to determine antibiotic resistance and to investigate the presence of AmpC beta-lactamase gene in clinical strains of Escherichia coli isolated from hospitalized patients in Tabriz. In this cross-sectional descriptive study, 289 E. coli specimens were collected from clinical specimens. Disk diffusion method and combined disk method were used to determine the phenotype of extended spectrum β-Lactamase producing (ESBLs) strains. Then PCR was used to evaluate the presence of AmpC (FOX) beta-lactamase gene in the strains confirmed in phenotypic tests. Antibiotic resistance was also determined using disk diffusion by the Kibry-Bauer method. A total of 121 isolates were identified as generators of beta-lactamase genes. 72 (59.5 %) isolates producing ESBL and 49 (40.5 %) isolates were identified as AmpC generators. In the PCR test, 31 isolates contained the FOX gene. The highest resistance was related to the antibiotics amoxicillin (76.12%), ceftazidime (70.24%) and nalidixic acid (65.05%). The results indicate an increase in the prevalence of beta-lactamase genes and increased resistance to beta-lactam antibiotics, which can be the result of improper use of antibiotics and not using antibiotic susceptibility tests before starting treatment. Also, using phenotypic and molecular diagnostic methods such as PCR together can be very useful.
Reverse shoulder arthroplasty-early results
Authors: SAY Ferhat , KUYUBAŞI Numan , PİŞKİN Ahmet , BÜLBÜL Murat
Published: May 2021

Although reverse shoulder arthroplasty is used in massive rotator cuff tears, it is also used in proximal humerus fractures and shoulder arthroplasty revision. In this study, we aimed to examine the early radiological and clinical results of patients undergoing reverse shoulder arthroplasty with different diagnoses. Between 2010 and 2013, reverse shoulder arthroplasty was applied to 10 patients (4 men, 6 women) with the diagnosis of arthropathy due to rotator cuff tear (n: 7), multi-fragmentary proximal humerus fracture (n: 2) and hemiarthroplasty revision (n: 1). The median age of the patients was 74 (64-85) years and the median follow-up was 15.5 (3-35) months. Patients were assessed in terms of joint range of motion, Constant score and Visual Pain Scale (VAS) and radiological examinations before and after surgery. Preoperative active shoulder flexion, abduction, internal and external rotation degrees of the patients were 65, 30, 40 and 50 degrees, and 105, 95, 30, 57.5 degrees respectively in their final controls. Constant score was 20.5 (14-63) preoperatively, and 54.5 (38-64) in the final controls (p˂0.05). While the preoperative VAS was 7 (3-9), it was found to be 1.5 (1-3) in the final controls (p˂0.05). As a complication, scapular notching was observed in one patient. Internal external rotation values were better in the rotator cuff arthropathy group than the fracture group. Reverse shoulder arthroplasty, especially in the treatment of patients with rotator cuff arthropathy, has good early results and a low complication rate. We recommend paying attention to the glenoid component location to avoid scapular notching.
The opinions of specialists and students regarding the use of visual and written expression forms in rhinoplasty education
Authors: KAYA Sefa Ersan , KEMAL Özgür , SOYLU KOYUNCU Sevgi
Published: May 2021

This research was conducted to investigate the contribution of visual and written expression to nasal surgery education and the preferences of usage. The research was conducted with the observation of cases in the Ear, Nose and Throat (ENT) Surgery Department of Ondokuz Mayıs University Medical Faculty. During the study, the processes of the ‘closed dorsum rhinoplasty’ cases were observed. The case illustrations made as a result of the observations were presented to the study population comprising 36 medical students from 3 different universities (Ondokuz Mayıs University, Hitit University, İstanbul Medeniyet University). Data were obtained concerning the sampling of the research, the specialization areas of the participants, title groups, number of participants, and the information from the Likert type responses and the non-parametric statistical findings. The results showed that although the use of illustrations was seen to be more important according to the opinion of specialists and non-specialists in the area, sole use was concluded to be insufficient. A total of 43 of 60 ENT specialists and 9 of 11 Plastic Surgery specialists preferred the use of illustrations, photographs and written expression together. Non-specialists were seen to be undecided about their responses while no significant difference was found between specialists. The preferences of the participants were determined to be illustration, photography and written expression, respectively. The results of this study indicate that the use of visual and written expression forms together when they are available is related to the quality of surgery education at a semantic level.
Endoscopic vacuum assisted closure of gastrocutaneous fistula after sleeve gastrectomy combined with fibrin sealant
Authors: CWALIŃSKI Jarosław , HERMANN Jacek , PASZKOWSKI Jacek , BANASIEWICZ Tomasz
Published: May 2021

Treatment of gastrointestinal fistulas after staple line leaks is difficult and non-invasive procedures such as endoclips, stents or endoscopic vacuum assisted closure (E-VAC) are sometimes not adequate. Fibrin sealants (FS) may promote healing, although today are used mainly to prevent anastomosis dehiscence within digestive tract. The authors present a 37-year-old female patient who developed a chronic gastrocutaneous fistula after sleeve gastrectomy for severe obesity treated successfully with a combination of E-VAC and a fibrin sealant. Long term peritoneal drainage, total parenteral nutrition, and antibiotic therapy for the next six weeks failed to close the leakage. Ultimately the fistula was closed after 6 changes of E-VAC and final implementation of a fibrin sealant. The duration of treatment was 81 days, including 34 days of E-VAC treatment and FS application. Complete closure of the fistula was visualized on gastroscopy six weeks after the treatment.
Clinical deterioration of Alzheimer’s disease patients during the Covid-19 pandemic and caregiver burden
Authors: HELVACI YILMAZ Nesrin , POLAT Burcu , ERMIS Abdulkadir , HANOGLU Lutfu
Published: May 2021

To investigate a possible deterioration of the symptoms of Alzheimer’s disease (AD) patients during a quarantine period of 60 days, and the impact on caregiver burden. This study consisted of 54 individuals (36 female, 18 male) aged 60 years and over who had been diagnosed with AD. During the quarantine period, caregivers of the patients (child, spouse, relatives) who were confined to their homes were contacted by phone and administered a survey composed of questions for neuropsychiatric symptoms and caregiver burden. Patients’ mean age was 77.18±6.96 years. The most worsening symptom was forgetfulness (35.2%) and agitation (24.1%). Incoherent speech, introversion, sleep disturbance, hallucinations, carry on with hobbies, reduced personal care, changes in appetite, and incontinence were less deteriorated. Of the caregivers, 61.1% thought that something terrible would happen to the patient, and 38.9% felt they could not find time for themselves. Drug rejection increased the burden twofold. Telemedicine methods, providing opportunities for the caregiver and the patient to walk outside, and giving medication that dissolves in the mouth or epidermal patches may be useful to prevent disease progression during the lockdown.
Effect of Adipose-Derived Mesenchymal Stem Cell on the Expressions of Bax/Bcl-2, Ki67, VEGF, TNF-α, and Endometrial Implants in Metformin-Administered Endometriosis Mice (A Mouse Model in Endometriosis Study)
Authors: Mulyantoro Inu , Pramono Noerpramana Noor , Febrianto Yuda Heru , Widjiati Widjiati , Purwati Purwati , Suhartono Suhartono , Djuwantono Tono , Wijaya Indra
Published: May 2021

Objective: Endometriosis is a gynecological syndrome that affects many women around the world. The effective management for this illness has not been determined. The aim of this study was to explore the effect of mesenchymal stem cells (MSCs) and metformin on Bax/Bcl-2, Ki67, VEGF, TNF-α, and endometrial implants in endometriosis mice. Materials and Methods: Thirty mice with endometriosis were equally divided into 5 experimental groups (S1: 0.1 ml MSCs + 4 mg metformin; S2: 0.1 ml MSCs; S3: 4 mg metformin; S4: 0.1 ml NaCl 9%; and S5: 4 mg metformin + subsequent 0.1 ml MSCs) for 14 days. On the 15th day, peritoneal tissues of mice and endometrial implants were removed to examine the expressions of Bax/Bcl-2, Ki67, VEGF, and TNF-α using immunohistochemical staining, and Allred index and endometrial implants using image tracing method with a computer. The obtained data were analyzed using the Kruskal-Wallis and ANOVA tests, followed by the Least Significant Difference (LSD) and Mann-Whitney Post-hoc tests. Results: There were significant differences in the expressions of Bax/Bcl-2 (p=0.002), Ki67 (p=0.004), TNF-α (p=0.017), and endometrial implants (p=0.001) in all groups, except for VEGF (p=0.079). The values of S2 didn’t differ much compared to the control group (S4) in the Bax/Bcl-2 (p=0.487), TNF-α (p=0.191), and endometrial implants (p=0.2). S1 was found to have the highest Bax/Bcl-2 (1.67±0.845) and lowest TNF-α (4.67±2.15) and endometrial implant (0.86±2.11). Conclusion: MSCs alone had not any beneficial effect on the treatment of endometriosis, whereas metformin by itself exhibited favorable results. The combination of MSCs and metformin at the same time shows superior outcomes.
PEMANFAATAN AGENDA DIAGNOSTIC READING DALAM PENENTUAN PROYEK PERUBAHAN PESERTA DIKLAT KEPEMIMPINAN TINGKAT II
Authors: Anita  , Dumalang Grace
Published: May 2021

Diklat kepemimpinan bertujuan untuk menghasilkan pemimpin yang mampu menyelesaikan permasalahanyang dihadapi organisasi dengan pendekatan-pendekatan yang lebih adaptif. Penelitian ini bertujuanuntuk mengetahui sejauh mana pemahaman dan pamanfaatan peserta terhadap mata agenda diagnosticreading. Metode penelitian yang digunakan adalah penelitian kualitatif khususnya studi kasus. Teknikpengumpulan data melalui wawancara dan telaah dokumen kebijakan. Data dianalisis secara deskriptifkualitatif. Hasil penelitian menunjukkan terdapat dua jenis pemahaman peserta Diklat KepemimpinanTingkat II terhadap Agenda diagnostic reading yaitu Pemahaman ekstra polation dan Pemahaman interpretation. Sebagian besar peserta tidak dapat mengoptimalkan pemanfaatan agenda diagnostic readingdalam menemukan solusi inovatif pada organisasinya.
Partisipasi Pemangku Kepentingan dalam Musyawarah Perencanaan Pembangunan di Kecamatan Tempe Kabupaten Wajo
Authors: Irham
Published: May 2021

Pembangunan daerah merupakan suatu usaha yang sistematik dari berbagai pelaku, baik pemerintah, swasta, maupun masyarakat. Penelitian ini bertujuan untuk mengetahui keterlibatan pemangku kepentingan dalam pelaksanaan musyawarah perencanaan pembangunan daerah di Kecamatan Tempe, Kabupaten Wajo. Penelitian ini menggunakan metode kualitatif dengan jenis penelitian deskriptif. Data diperoleh menggunakan teknik observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa aspek keterlibatan masyakat dalam musrenbang di Kecamatan Tempe  hanya sebatas pada jenjang partisipasi informasi. Masyarakat sedikit terlibat dalam proses penyusunan dan perumusan kegiatan, walaupun masyarakat dapat memberikan usulan, namun masyarakat tidak memiliki kekuasaan dalam menentukan keputusan akhir. Pengambilan keputusan tetap di tangan pemerintah, selain itu tidak ada kontrol dan pangawasan dari masyarakat. Sedangkan keterlibatan pemerintah pada proses musrenbang di Kecamatan Tempe lebih bersifat partisipasi fungsional, dimana hal tersebut berarti pemerintah masih memegang peran yang kuat terhadap proses pelaksanaan musrenbang. Hal itu didukung oleh peraturan perundang-undangan yang menyebutkan bahwa pemerintah wajib melaksanakan musrenbang dan menjadi penanggung jawab jalannya kegiatan musrenbang.
KONTEKTUALISASI TEORI MULTI ARUS
Authors: Fajar Iswahyudi
Published: May 2021

Teori multi arus telah banyak digunakan dalam menjelaskan pembuatan kebijakan. Namun demikian, teori multi arus memiliki kelemahan dalam menjelaskan pengaruh konteks pembuatan kebijakan. Teori kelembagaan menjadi alternatif teori untuk menjelaskan konteks pembuatan kebijakan. Penelitian ini akan menjelaskan bagaimana teori multi arus dan teori kelembagaan digunakan untuk menjelaskan pembuatan kebijakan. Penelitian ini dilakukan dengan metode kualitatif dengan pendekatan studi kasus. Studi kasus yang dipilih adalah kegagalan pembuatan karantina wilayah di DKI Jakarta. Hasil penelitian ini menunjukan bahwa kegagalan disebabkan oleh adanya faktor kelembagaan yang timbul guna mencegah terjadinya tragedy of common dan prisoner’s dillema. Dari segi teoritis, penelitian ini menemukan bahwa teori kelembagaan dapat membantu melengkapi teori multi arus dalam menjelaskan pembuatan kebijakan dari segi konteks pembuatan kebijakan.
EFEKTIVITAS PERATURAN KEPALA DAERAH TENTANG PENINGKATAN DISIPLIN DAN PENEGAKAN HUKUM PROTOKOL KESEHATAN DI LINGKUNGAN PEMERINTAH DAERAH
Authors: Tri Wahyuni
Published: May 2021

Dari awal keberadaannya hingga saat ini, Covid-19 telah menimbulkan kepanikan. Mendekati akhir Tahun 2020, angka penularan Covid-19 bukan melandai, justru meningkat. Guna menggawang pelaksanaan adaptasi kebiasaan baru, pemerintah telah mengeluarkan kebijakan Inpres No. 6 tahun 2020 tentang Peningkatan Disiplin Dan Penegakan Hukum Protokol Kesehatan Dalam Pencegahan Dan Pengendalian Covid- 2019. Di dalam Inpres disebutkan bahwa Para Gubernur, Bupati, dan Wali kota diperintahkan untuk menyusun dan menetapkan peraturan gubernur/peraturan bupati/wali kota yang memuat kewajiban mematuhi protokol kesehatan serta memuat sanksi terhadap pelanggaran penerapan protokol kesehatan.

Dalam prakteknya, peraturan kepala daerah yang telah disusun, tidak selalu ditaati. Berbagai pelanggaran masih cenderung terjadi. Oleh karenanya, perlu bagi setiap daerah untuk melihat kembali substansi regulasi kepala daerahnya, apakah sudah efektif secara substansi atau belum. Penelitian ini bertujuan untuk melihat efektivitas substansi peraturan kepala daerah tentang penerapan disiplin dan penegakan hukum protokol kesehatan. Penilaian efektivitas didasarkan pada terakomodasi atau tidaknya faktor – faktor dari sebuah konsep implementasi kebijakan di dalam peraturan kepala daerah. Adapun konsep implementasi yang digunakan sebagai dasar penerapan efektivitas, adalah  konsep implementasi kebijakan Edward III yang terdiri dari empat unsur kritikal faktor, meliputi : komunikasi, sumber daya, perilaku, dan struktur organisasi. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan tipe penelitian deskriptif.
Anti-Hypertensive Activity of Hydro Alcoholic Extract of Cìraka Cūraṇam on High Salt Loaded Wistar Albino Rats
Authors: K Sujeethasai , A Manoharan , M Santhanakumar
Published: May 2021

Background: Hypertension is called as Silent killer. The most important risk factor for heart diseases and stroke and it may leads to premature death. Several medicinal plants have high effective in anti-hypertensive and anti-thrombotic activity without any side effects.
Aim: To evaluate the anti-hypertensive activity of hydro alcoholic extract of Cìraka cūraṇam on deoxycorticosterone acetate (DOCA) salt induced wistar albino rats.
Study design: Observational in-vivo study
Place and duration of study: Animal house, Dept. of Pharmacology, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Srivilliputtur,Tamilnadu.
Materials and methods: Antihypertensive activity was conducted on wistar albino rats by determining serum Sodium and Potassium levels by using semi auto analyzer (RA-50, Bayer Diagnostics), using specific kits (Auto span, India) at 500 and 550 nm respectively and left carotid artery (for recording BP) was cannulated under aseptic conditions with polyethylene cannula filled with 1% heparin in normal saline. Rest procedure, which was stated under the 2K1C-model was followed and BP was observed in terms of mm of Hg.
Results: The Cìraka cūraṇam possesses strong antihypertensive effect against DOCA-salt hypertensive rats, which is evidenced by a considerable decrease in blood pressures.

Keywords: Anti-hypertensive activity, Cìraka cūraṇam, Wistar albino rats, Deoxycorticosterone acetate.
GAMBARAN PEMBERIAN TERAPI MUSIK KLASIK UNTUK MENGATASI NYERI PADA PASIEN POST OPERASI HERNIA DI RSUD BARNJARNEGARA
Authors:   Politeknik Yakpermas Banyumas, Imanda Rivana Dian , Julianto Eko ,   Politeknik Yakpermas Banyumas, Ajiningtyas Eko Sari ,   Politeknik Yakpermas Banyumas
Published: May 2021

Latar belakang : Pasien post operasi hernia yang mengalami nyeri yang tidak mendapatkan penanganan yang tepat dapat menyebabkan perasaan tidak nyaman dan tidak bisa melakukan aktivitas seperti biasanya. Terapi musik memberikan kesempatan bagi tubuh dan pikiran untuk relaksasi yang sempurna,seluruh sel dalam tubuh akan mengalami penyembuhan alami dan produksi hormon tubuh diseimbangkan dan pikiran mengalami penyegaran.Tujuan : Untuk menggambarkan asuhan keperawatan dengan terapi musik klasik untuk menurunkan nyeri pada pasien post operasi hernia.Hasil : Selama 3 hari, telah dilakukan asuhan keperawatan dengan melakukan terapi musik klasik pada pasien post operasi hernia, nyeri yang dirasakan pasien menurun. Untuk skala nyeti rata rata 1-3 nyeri ringan, 4-6 nyeri sedang, 7-10 nyeri akut.Kesimpulan : Terapi musik klasik dapat mengatasi nyeri pada pasien post operasi hernia. Teknik terapi musik klasik dapat menjadi alternatif untuk menurunkan nyeri pada pasien post operasi hernia
LITERATUR REVIEW: PENGARUH TERAPI DISTRAKSI AUDIOVISUAL PADA SAAT PROSEDUR INJEKSI PADA ANAK USIA PRASEKOLAH SAAT HOSPITALISASI
Authors:   Politeknik Yakpermas Banyumas, Mulyono Adi , Indriyani Puji ,   Politeknik Yakpermas Banyumas, Ningtyas Rahaju ,   Politeknik Yakpermas Banyumas
Published: May 2021

Latar belakang: Anak merupakan individu yang berada dalam satu rentang perubahan perkembangan yang dimulai dari bayi hingga remaja (Hidayat, 2009). Anak yang sedang sakit mempunyai respon berbeda, salah satunya yaitu anak akan mengalami kecemasan serta tidak bisa berinteraksi dengan orang lain, hal ini disebabkan karena anak harus menjalani proses perawatan di rumah sakit yang dikenal dengan proses hospitalisasi. Kecemasan merupakan perasaan yang paling umum dialami oleh pasien anak dengan hospitalisasi. Distraksi adalah metode untuk menghilangkan stress dan kecemasan dengan cara mengalihkan perhatian pada hal-hal lain sehingga pasien akan lupa terhadap cemas yang dialami. Tujuan: Untuk mendapatkan gambaran tentang pengaruh terapi distraksi audiovisual pada saat prosedur injeksi pada anak usia prasekolah saat hospitalisasi. Metode: Desain yang digunakan pada penelitian ini adalah penelitian kepustakaan, sumber data yang diperoleh dari data sekunder dimana peneliti memperoleh sumber utama hasil literatur- literatur yang berkaitan dengan fokus kajian dari tahun 2015- 2020, dengan menggunakan 4 jurnal dan buku- buku yang membahas konsep keperawatan anak yang dijadikan sebagai referensi tetapi hanya 2 jurnal yang dijadikan sebagai landasan teori. Hasil: Dari kedua jurnal memberikan hasil bahwa terapi distraksi audiovisual sangat berpengaruh terhadap penurunan tingkat kecemasan dan tingkat nyeri pada anak usia prasekolah pada saat prosedur injeksi. Kesimpulan: Terapi distraksi audiovisual sangat berpengaruh terhadap penurunan tingkat kecemasan dan tingkat nyeri pada anak usia prasekolah pada saat prosedur injeksi.
State of the art of Islamic finance in Morocco
Authors: El Ouakili Ahmed , Talha Fatma , Artis Amelie
Published: May 2021

Islamic finance is now an essential component of global finance. It knows vertiginous growth in several Muslim countries like the Gulf and Southeast Asia countries. It has shown innovation and has been able to set up in several non-Muslim countries where it coexists with conventional finance. Indeed, the increased demand for Islamic financial products has made it nowadays a primordial player that no country can no longer neglect. This is how we will try to focus on the ethical dimension of Islamic finance. Before explicing any issues that it would present for all socio-economic operators in Morocco, particularly to commercial banks, Bank Al -Maghrib, the Treasury and local financial market players. Then we will discuss the opportunities it would provide for its contribution to the financing of the priority sectors for Morocco, the banking of its population and the promotion of social solidarity through the establishment of the funds of the Zakat.
Global MNC Tax Complexity Survey
Authors:   TRR 266 Accounting for Transparency, Hoppe Thomas , Schanz Deborah , Schipp Adrian , Siegel Felix , Sturm Susann , Sureth-Sloane Caren
Published: May 2021

This report presents the first descriptive results of the 2018 Global MNC Tax Complexity Survey.
Steuerliche Verwaltungskosten, steuerliche Corona-Soforthilfemaßnahmen und Investitionen in der Krise
Authors: Heile Vanessa , Huber Hans-Peter , Maiterth Ralf , Sureth-Sloane Caren
Published: May 2021

Dieser Bericht stellt die deskriptiven Ergebnisse der Befragung „Steuerliche Verwaltungskosten, steuerliche Corona-Soforthilfemaßnahmen und Investitionen in der Krise“ vor. Die Online-Befragung erfolgte im Zeitraum vom 13. Mai 2020 bis zum 25. Juni 2020.
Volatile oil of Teucrium alopecurus sensitizes colon cancer cells to TRAIL-induced cell death
Authors: Guesmi Fatma , Prasad Sahdeo , Tahri Wiem , Dridi Imen , Ali Manel Ben , Hedfi Amor , Ismail Ismail A. , Landoulsi Ahmed
Published: May 2021

TNF-related apoptosis-inducing ligand (TRAIL/Apo2L), a member of cytokine family, is known to selectively induce apoptosis in cancer cells. However, developing resistance to TRAIL is a major obstacle in cancer therapy. In this study, the in vitro effect of Teucrium alopecurus (TA) essential oil on inhibition of cancer cell growth and enhancing TRAIL-induced apoptosis were investigated in colon cancer cells. Untreated tumor cell lines are used as controls. TA induced cell death and increased the anticancer effects of TRAIL as observed by cell toxicity, live/dead assay, cleavage of caspases and PARP. Furthermore, the mechanism of anticancer potentiating effect of TA was found to be linked with the upregulation of death receptors (DRs) and reduced expression of TRAIL decoy receptors (DcRs). TA also down-regulated antiapoptotic proteins and induced p53 in colon cancer cells. In addition, we observed upregulation of MAPK signalling pathway (p38 kinase, JNK, ERK) and increased expression of C/EBP homologous transcription factor (CHOP) and specificity protein 1 (SP1) by TA. These findings demonstrate the potent anticancer effect of bioactive constituents of Teucrium alopecurus essential oil.
Gut dysbiosis, insulin resistance and Alzheimer’s disease: review of a novel approach to neurodegeneration
Authors: Lazar Evelyn , Sherzai Ayesha , Adeghate Jennifer , Sherzai Dean
Published: May 2021

Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) share many common features including inflammation, oxidative stress and neuronal degeneration. Insulin resistance (IR) appears to be a common path in these pathological processes. IR is an early pathogenic event in AD, which leads to augmentation of hyperphosphorylated tau and Amyloid beta (Aβ). The reviewed studies related to AD have revealed a positive association between T2DM and AD. This association was maintained in peripheral hyperinsulinemia cases without the presence of T2DM, which might be due to decreased insulin transport to the brain or the inadequate cerebral insulin production. Gut dysbiosis induces inflammation and consequently provokes both peripheral and cerebral IR and can amplify processes promoting AD. Additionally, the risk of increased progression of AD was revealed due to pre-diabetes, T2DM and gut dysbiosis. The pro-inflammatory changes might affect progression of AD pathology by inhibition of the autophago-lysosomal pathway and cerebral insulin signaling pathway. This review elaborates the role that cerebral IR might play in the underlying pathological events in AD.
Approaches for network based drug discovery
Authors: Jayachandran Priyanka , Ilango Suganya , Paital Biswaranjan , Bhanja Shravani , Nirmaladevi Ramalingam
Published: May 2021

Molecular network-based studies have gained tremendous importance in biomedical research. Several such advanced technologies in molecular biology have evolved in the past decade and have contributed to building up enormous molecular data. These molecular networks gained much significance among researchers triggering widespread use of experimental and computational tools. This interest led researchers to compile data of biomolecules systematically and to develop various computational tools for analyzing data. In the present scenario, an enormous amount of molecular network databases are available which can be accessed freely by the public. This is the central focus of this article.
Yoga in major depressive disorder: molecular mechanisms and clinical utility
Authors: Tolahunase Madhuri Rajaneesh , Gautam Surabhi , Sagar Rajesh , Kumar Manoj , Dada Rima
Published: May 2021

Major depressive disorder (MDD) is a mind-body disorder. Cellular aging has been implicated in the pathogenesis of MDD with the altered mind-body communication markers like stress response, immune response, nutrition sensing, and a range of other regulatory feedback systems. In this age of super specializations, one specific target and interventions (preferably a drug) on it are being rigorously sought by the health care community and industry, but have failed in it in the last fifty years in spite of advances in technology. Since, depression is a complex disorder associated with increased incidence of other complex disorders, it must be treated by an integrated holistic approach that can address the complexity of MDD. Interventions targeting accelerated biological aging to increase cellular health in whole body have potential to manage complex conditions like MDD and its overlapping symptoms and comorbidities. Yoga has the potential to be the nexus between, clinical management of MDD and other lifestyle diseases.
Human Capital Development and Economic Development in Nigeria
Authors: M. Raymond , N. Ekponaanuadum
Published: May 2021

This paper set out to investigate the impact of human capital development on the drive to achieving economic development in Nigerian. It adopted the Ex-post facto research design as the variables-Misery Index, GEH and GEE cannot be manipulated as they have previously occurred. The study span for a period of 38 years which covered from 1981 – 2018. Secondary data sourced from the statistical bulletin of the Central Bank of Nigeria and the world development index of the World Bank was utilized for this study. The study employed the ordinary least square (OLS) method and the Error Correction Model estimation technique to examine the long run relationship and short run dynamics of the variables. The result of the Johansen co-integration test established the presence of long run relationship between misery index, pupil teacher ratio, government spending on education and health. The result of the ordinary least square revealed a negative and significant relationship between misery index and pupil teacher ratio in the long run. The results of the short run analysis revealed that current level of pupil teacher ratio impact on the misery index in Nigeria negatively and significantly. Informed by the discoveries, the study proposed the recruitment of more teachers to improve the current pupil teacher ratio in the country and also increase the budgetary allocation to the education sector.
A Comprehensive Study on Anti-hypertensive properties of Punica granatum (Pomegranate), Cynara scolymus (Artichoke), Coscinium fenestratum (Yellow vine) in Phytopharmacological, Molecular Biology Researches
Authors: Jough Sagar Singh , Saini Rakesh Kumar , Parveen Aamna
Published: May 2021

Hypertension is a turning into a significant danger to the world. In the hunt of lead atoms from plant beginning as a substitute for poisonous engineered drugs, 26 Indian restorative plants and nourishments were screened for their ACE (Angiotensin Converting Enzyme) inhibitory movement. IC50 (half restraint of ACE) estimations of hydroalcoholic unrefined concentrates and division were dictated by a colorimetric technique. Dynamic parts were additionally screened to decide the compound energy, mode, explicitness and instrument of restraint. Normalization was finished by deciding aggregate phenolics and flavonoids as gallic corrosive and quercetin counterparts/mg of concentrate individually. Among 26 unrefined concentrates, Cynara scolymus extricate indicated the best action, IC50 esteem 356.62µg/mL. Pro restraint coming about because of protein precipitation was most noteworthy in Coscinium fenestratum. Lineweaver-Burk plots uncovered a serious method of restraint for Punica granatum ethyl acetic acid derivation part. Divisions of Cynara scolymus were seen as vague inhibitors of ACE. Coscinium fenestratum parts restrained the ACE by Zn2+ particle chelation. Further, in the quest for sheltered and powerful lead atoms from normal sources, (MP) Mucuna pruriens L. (Fabaceae) seeds were used for investigating the antihypertensive potential. Generally it is utilized as diuretic and Hypotensive. Bioassay-guided divisions were used for the separation of dynamic mixes by segment chromatography. IC50 esteem, protein energy and restraint system were resolved. In vivo time and portion subordinate hypotensive examination followed by changes in the MAP (Mean blood vessel pressure) actuated by angiotensin I (3 nmol/kg), angiotensin II (3nmol/kg), and to bradykinin (10nmol/kg) in anesthetized rodents was finished. Plasma and tissue ACE exercises were additionally decided. Phytochemical examination by spectroscopic methods uncovered the nearness of realized mixes like genistein, ursolic corrosive and L-DOPA from the ethyl acetic acid derivation and water part separately. In vitro examination uncovered MP ethyl acetic acid derivation portion (MPEA) and genistein as the most dynamic part (IC50 156.45µg/mL) and compound (IC50 253.81µM) individually. Lineweaver-Burk plots uncovered a non-serious method of hindrance. Expert protein precipitation was the recommended instrument for restraint. The concentrate indicated a time and portion subordinate decline in the MAP.
A Short Review on Fluidized Bed Dryer
Authors: Mali Akash H. , Nikam Aditya R. , Shaikh. Azam Z.
Published: May 2021

This artical also discusses about demostration of fluidized bed dryer with principle and application and other processing. This has lead to development of thechnology, process and equipments which not only reduce time but also increasing the output. A Fluidized bed dryer significantely reduce drying time, compared with vaccum dryer or tray dryer. In the pharmacutical industry, fluidized bed dryer are typically used for pellets drying, coating and granulation. Fluidized bed drying are very well known to yield high heat and mass transfer and hence adopted to many industrial drying process particularly pharmacy product. In this paper we show construction, working of the fluidized bed dryer. It work on the drying principle. It has several advantages and disadvantages.
Role of ZnO Nanoparticles for improvement of Antibacterial Activity in Food Packaging
Authors: Sehar Saira , Amiza Amiza , Khan I. H
Published: May 2021

Nanotechnology advancement leads to development of antimicrobial agents like ZnO nanoparticles. These nanoparticle have their main applications in food packaging. when these nanoparticles incorporate into the food surface, it will kill all bacterias residing on the surface and food become free of bacteria. In this way, food can be stored for a long time because its shelf life is improved. Antimicrobial activity of ZnO nanoparticles can be improved by increasing surface area, reducing particle size and large concentration of ZnO –NPS. Antimicrobial activity increases by increasing intensity of UV light. As UV light fall on ZnO nanoparticles, it increases ZnO surface area and hence anrtimicrobial activity will be increased. Exact mechanism of Antimicrobial activity is still unknown but some processes have been presented.
ADVANTAGES OF PRE-PROSTHETIC MASTICATORY SYSTEM PREPARATION WITH OCCLUSAL APPLIANCE
Authors:   Department of Prosthetic Dental Medicine, Faculty of Dental Medicine, Medical University – Sofia, Bulgaria., Yankova Mariana , Dimitrova Desislava ,   Dental Clinic “Edinstvo”– Sofia, Bulgaria, Peev Todor ,   Private Practice, Sofia, Bulgaria., Yordanov Bozhidar ,   Department of Prosthetic Dental Medicine, Faculty of Dental Medicine, Medical University – Sofia, Bulgaria.
Published: May 2021

The aim of this literature review is to present the main advantages of pre-prosthetic preparation of the masticatory system with occlusal appliances. The possibilities for attaining muscle relaxation at the achieved centric condyle position in the temporomandibular joints are discussed. The advantages, in terms of hard dental tissue protection, the diagnostic value and the psychoprophylactic effect, are considered. The wide-ranging benefits of the use of occlusal appliances in bruxism- and bruxomania-related craniomandibular dysfunctions are indisputable and represent a current scientific interest.
Nome social e a plena cidadania T
Authors: Rodrigo Cássio , Rodrigo Cássio
Published: May 2021

O texto aborda o conceito de nome social para travestis, mulheres transexuais e homens trans e como o mesmo se reverte em políticas públicas no Estado de São Paulo em áreas como Educação, Administração Penitenciária e Segurança Pública. Apresentamos a legislação existente em relação ao tema e como ela se desdobrou para as demais áreas de governança, buscando garantir plena cidadania para essa parcela da população. Com alto índice de evasão escolar, demonstramos como o respeito à identidade de gênero e ao nome social podem ser fatores preponderantes para a permanência de travestis, mulheres transexuais e homens trans nos bancos escolares.
Transfobia e racismo
Authors: Moreira de Jesus Menezes Lincoln
Published: May 2021

O artigo discute a articulação de violências de gênero e raça vividas por trans negras, baseado em pesquisa realizada na cidade de São Paulo. Observa-se que a violência de gênero atingiu mais de 85,0% delas, além da violência racial vivida por 31,7%, em diferentes espaços sociais como escola, trabalho, no trato de instituições públicas e privadas, autoridades, Polícia e até vindas da família. Essas somadas à saída de casa mais cedo, a menor escolaridade e renda e a exposição a relações sexuais mais cedo, promovem condições desvantajosas e violências sociais na vivência dessas pessoas, estigmatizadas socialmente.
AMTIGOS - Ambulatório Transdisciplinar de Identidade de Gênero e Orientação Sexual, do IPq-HCFM/USP
Authors: Saadeh Alexandre , De Oliveira Caetano Liliane , Gonzalez Luciane , Bork Beatriz , Monteiro Cordeiro Desirèe , do Espírito Santo Cassiana Léa , Pinto Benedito Leandro Augusto , De Cillo Arantes Matheus , Barossi Zoe , Mori Gagliott Daniel Augusto , Ciasca Saulo Vito , Schlüter Karine , Saavedra Maíra Caricari
Published: May 2021

O artigo traz a experiência acumulada pelo Ambulatório Transdisciplinar de Identidade de Gênero e Orientação Sexual do Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (AMTIGOS-IPq-HCFM/USP), que atualmente se volta para a atenção de crianças e adolescentes transexuais, com equipe multidispliciplinar que inclui atenção familiar, psicológica e psiquiátrica, médica integral incluindo acompanhamento clínico e terapia hormonal, além orientação e realização da transexualização e a atenção ao longo período de espera da cirurgia. Apresenta como essa atenção em saúde vem contribuindo para o bem-estar e cidadania dessas pessoas e auxiliando seus familiares a integrá-los com suas necessidades específicas.
Programa São Paulo pela Primeiríssima Infância
Authors: Marino Eduardo
Published: May 2021

A primeira infância, período que vai da gestação até os 6 anos de idade, pode ser considerada o alicerce de todo o ciclo da vida dos indivíduos e de suas ações na sociedade. Nessa fase, o envolvimento e a participação da família e sua rede de apoio, bem como o fortalecimento das políticas públicas que organizam serviços de suporte às necessidades das famílias e das crianças, são essenciais. Nessa perspectiva, a Fundação Maria Cecilia Souto Vidigal firmou um convênio com o Governo do Estado de São Paulo, por meio da Secretaria de Estado da Saúde (SES-SP), que instituiu a criação do Programa São Paulo pela Primeiríssima Infância – SPPI, o qual atua e se estrutura em quatro eixos principais: Governança; Formação; Mobilização da sociedade; e Avaliação, todos vinculados à promoção do Desenvolvimento Infantil desde a gestação até os 3 anos de vida. Destaca-se que investir em iniciativas como o São Paulo pela Primeiríssima Infância, que buscam fortalecer e promover políticas públicas em prol do Desenvolvimento Infantil Integral e Integrado, é de extrema relevância às crianças, famílias e sociedade.
Formação intersetorial em práticas ampliadas de pré-natal, puerpério e amamentação
Authors: dos Santos Marcos Davi
Published: May 2021

O artigo introduz a abordagem “Pré-natal, puerpério e amamentação: práticas ampliadas (PNPA)”, analisa as diferentes possibilidades de construção familiar e compartilha a experiência de sua aplicação no Programa São Paulo pela Primeiríssima Infância.
Humanização obstétrica ou a humanização da gestação, do trabalho de parto, do parto, do nascimento e do aleitamento materno
Authors: Miyashita Newton Tomio
Published: May 2021

O artigo retoma a importância da criação dos Centros de Parto Normal (CPN) para o atendimento à mulher no período gravídico-puerperal e discorre sobre as iniciativas criadas a partir de programas institucionalizados de humanização do parto e do nascimento.
Saber compartilhado no cuidado ao portador de diabetes mellitus como produto de uma pesquisa de mestrado profissional
Authors: De Andrade Rafael Tadeu , Sterman Heimann Luiza
Published: May 2021

Introdução: O mestrado profissional promoveu a possibilidade de agregar valor no âmbito do Sistema Único de Saúde (SUS) por meio da qualificação de seus trabalhadores selecionados para o Programa de Mestrado Profissional do Instituto de Saúde, bem como o desenvolvimento de pesquisas cujos objetos respondam a necessidades do Sistema e dos Serviços de Saúde. A partir da percepção dos profissionais sobre uma alta proporção de encaminhamentos desnecessários à atenção especializada foi possível identificar a situação-problema e formular estratégias de enfrentamento. Objetivo: Identificar o problema e promover mudanças nas práticas de cuidado do paciente portador de diabetes mellitus. Método: Essa pesquisa foi caracterizada como uma pesquisa de implementação, onde foi utilizada triangulação de métodos: pesquisa-ação e pré e pós-testes. Resultados: No âmbito dos serviços a elaboração e implementação do apoio matricial da atenção especializada à atenção básica contemplou a troca de conhecimento entre os profissionais dos diversos pontos da rede; redução na proporção de encaminhamentos desnecessários de pacientes portadores de diabetes mellitus à especialidade de endocrinologia e mudanças na prática do cuidado.
Saúde da população Síria
Authors: Correia Loureiro Tonini Sandra Cristina , Kalckman Suzana
Published: May 2021

O estudo objetivou conhecer percepções, atitudes e práticas dos profissionais de Unidades Básicas de Saúde sobre a população síria. Metodologia: Estudo qualitativo exploratório, utilizando grupos focais para coleta de dados junto aos profissionais de saúde e entrevista com representante de entidade de acolhida a refugiados. Resultados: Foram estabelecidas as seguintes categorias de análise: 1. Perfil da população Síria que procura por atendimento na UBS; 2. Motivos pelos quais o serviço de saúde é procurado; 3. Dificuldades percebidas durante o atendimento à população síria; 4. Recursos utilizados para lidar com as dificuldades no atendimento; 5. Aspectos culturais de interferência na saúde da população síria. A procura por atendimento médico ocorre predominantemente nos Hospitais e Pronto Atendimento. Os serviços mais utilizados foram: pré-natal, tratamento de doenças crônicas, atendimento psicológico e vacinação. As dificuldades percebidas apontadas foram: a linguagem, hábitos e costumes, estigmas sobre a cultura e religião, discriminação, preconceito e falta de documentos. Os recursos utilizados referem-se principalmente a comunicação. Fatores de interferência identificados: costumes, hábitos, crenças, linguagem, doenças préexistentes, religião, violência doméstica e social e a adesão ao tratamento. Necessidades identificadas para o SUS: treinamento aos profissionais de saúde sobre multiculturalidade e a aproximação dos serviços de saúde às Organizações Não Governamentais que trabalham com essa população.
Rzecz o Kubusiu i Fredzi, czyli o nazwach własnych w dwóch polskich przekładach tekstów Alana Alexandra Milne’a
Authors: Misior-Mroczkowska Aleksandra
Published: May 2021

Winnie­the­Pooh, a literary work published by Alan Alexander Milne in 1926, has been appreciated by readers worldwide for nearly a century. The story about a little bear and his companions was first bellowed in book version, then became one of Disney’s best and unforgettable adaptations. The text proves rather difficult to translate, for Milne demonstrated great creativity, particularly in naming his characters and various places. It is rife with many ambiguous expressions, neologisms, onomatopoeias, and intentional language errors. The name of the eponymous bear, for instance, Winnie­the­Pooh, well illustrates the difficulty in translation, for Winnie, a reportedly diminutive form of Winifred, is allegedly a female name, whereas the bear is referred to as male. The Pooh part has also proven problematic in translation.The following article is an attempt at analyzing selected proper names in two Polish translations of the story. In 1938, Irena Tuwim published a translation entitled Kubuś Puchatek, which Polish readers immediately fell in love with. In 1986, Monika Adamczyk-Garbowska published her translation, Fredzia Phi­Phi. It attracted a deluge of negative com-ments and contemptuous reactions with many readers expressing dislike for Fredzia Phi­Phi, viewing it as a crime against the lauded first translation – which, as it happens, contains many mistakes and strays far from the original text.