bluuebunny/crossref_metadata_2025 huggingface dataset:
Reminiscence therapy-based care program alleviates anxiety and depression, as well as improves the quality of life in recurrent gastric cancer patients
Authors: Wu Xing , Zhang Weiwei
Published: June 2023

Objective

Reminiscence therapy is a non-drug method that eases psychological burden and enhances quality of life by memories and communications in cancer patients. This study aimed to evaluate influence of reminiscence therapy-based care program on anxiety, depression, and quality of life in recurrent gastric cancer patients.

Methods

Totally, 96 recurrent gastric cancer patients were randomly assigned as 1:1 ratio into reminiscence therapy-based care group (N = 48) and usual care group (N = 48) to receive 12-week corresponding interventions. Besides, all patients were follow-up for 6 months.

Results

Hospital Anxiety and Depression Scales-anxiety score at 4th month (p = 0.031) and 6th month (p = 0.004), Hospital Anxiety and Depression Scales-depression score at 6th month (p = 0.018), and anxiety severity at 4th month (p = 0.041) and 6th month (p = 0.037) were lower in reminiscence therapy-based care group than in usual care group. Quality of Life Questionnaire-Core 30 global health status score at 2nd month (p = 0.048), 4th month (p = 0.036), and 6th month (p = 0.014), Quality of Life Questionnaire-Core 30 function score at 4th month (p = 0.014) and 6th month (p = 0.021) were higher, while Quality of Life Questionnaire-Core 30 symptoms score at 2nd month (p = 0.041) and 4th month (p = 0.035) were lower in reminiscence therapy-based care group than in usual care group. Furthermore, reminiscence therapy-based care was more effective on improving mental health and quality of life in recurrent gastric cancer patients with anxiety or depression at baseline than those without.

Conclusion

Reminiscence therapy-based care serves as an effective intervention, which relieves anxiety and depression, and improves quality of life in recurrent gastric cancer patients.
The longitudinal influence of the level of executive function development on children’s transcriptional skills: a modern view of A. Luria’s ideas
Authors: Oshchepkova Ekaterina S. , Shatskaya Arina N. , Kovyazina Maria S.
Published: June 2023

In the realm of Cultural-Historical Theory, A. Luria suggested writing as a model of a complex system of higher mental function, since that function is based on various psycho-physiological mechanisms, including processing of audial and visual information; and as a complex system of the frontal lobe functions of overcoming perseveration, and creation and control of the writing program. Subsequent research on these topics has shown a close association between the level of development of executive functions (EF) and writing skills. Nevertheless, the question of which parts of EF influence which aspects of writing, remains unresolved. In addition, there are few longitudinal studies of EF’s influence on writing. In this article, we focus on the results of a longitudinal study of the influence of EF in children 6.3 years old on their mastery of basic writing skills at the age of 7.5. The results of regression model construction showed that all the aspects of executive functions strongly influenced the children’s transcription skills, while the greatest impact on the development of the graphomotor component and spelling skills was exerted by working memory and inhibition control. These results are consistent with studies that have shown a correlation between the development of writing skills and EF. These results also confirm A. Luria’s views on the importance of functions responsible for processing audial and visual information in the process of writing, and the importance of suppressing irrelevant stimuli and perseverations. Our research shows the importance of the development of EF in preschool childhood.
Sleep spindles across youth affected by schizophrenia or anti-N-methyl-D-aspartate-receptor encephalitis
Authors: Dimitriades Maria E. , Markovic Andjela , Gefferie Silvano R. , Buckley Ashura , Driver David I. , Rapoport Judith L. , Nosadini Margherita , Rostasy Kevin , Sartori Stefano , Suppiej Agnese , Kurth Salome , Franscini Maurizia , Walitza Susanne , Huber Reto , Tarokh Leila , Bölsterli Bigna K. , Gerstenberg Miriam
Published: June 2023

Background

Sleep disturbances are intertwined with the progression and pathophysiology of psychotic symptoms in schizophrenia. Reductions in sleep spindles, a major electrophysiological oscillation during non-rapid eye movement sleep, have been identified in patients with schizophrenia as a potential biomarker representing the impaired integrity of the thalamocortical network. Altered glutamatergic neurotransmission within this network via a hypofunction of the N-methyl-D-aspartate receptor (NMDAR) is one of the hypotheses at the heart of schizophrenia. This pathomechanism and the symptomatology are shared by anti-NMDAR encephalitis (NMDARE), where antibodies specific to the NMDAR induce a reduction of functional NMDAR. However, sleep spindle parameters have yet to be investigated in NMDARE and a comparison of these rare patients with young individuals with schizophrenia and healthy controls (HC) is lacking. This study aims to assess and compare sleep spindles across young patients affected by Childhood-Onset Schizophrenia (COS), Early-Onset Schizophrenia, (EOS), or NMDARE and HC. Further, the potential relationship between sleep spindle parameters in COS and EOS and the duration of the disease is examined.

Methods

Sleep EEG data of patients with COS (N = 17), EOS (N = 11), NMDARE (N = 8) aged 7–21 years old, and age- and sex-matched HC (N = 36) were assessed in 17 (COS, EOS) or 5 (NMDARE) electrodes. Sleep spindle parameters (sleep spindle density, maximum amplitude, and sigma power) were analyzed.

Results

Central sleep spindle density, maximum amplitude, and sigma power were reduced when comparing all patients with psychosis to all HC. Between patient group comparisons showed no differences in central spindle density but lower central maximum amplitude and sigma power in patients with COS compared to patients with EOS or NMDARE. Assessing the topography of spindle density, it was significantly reduced over 15/17 electrodes in COS, 3/17 in EOS, and 0/5 in NMDARE compared to HC. In the pooled sample of COS and EOS, a longer duration of illness was associated with lower central sigma power.

Conclusions

Patients with COS demonstrated more pronounced impairments of sleep spindles compared to patients with EOS and NMDARE. In this sample, there is no strong evidence that changes in NMDAR activity are related to spindle deficits.
Implementation strategies for occupational therapists to advance goal setting and goal management
Authors: Kang Eunyoung , Chen Julie , Foster Erin R.
Published: June 2023

Background

There is a need for an effective evidence-based system to support high-quality goal setting and goal management implementation. We developed a new system for community-based rehabilitation, MyGoals, along with implementation strategies to support occupational therapists (OTs) in its administration. This study evaluates the acceptability, appropriateness, and feasibility of the implementation strategies,Clinician EducationandAudit & Feedback. It also explores whether OTs achieve the change objectives of the MyGoals implementation strategies and MyGoals intervention fidelity.

Methods

This mixed-methods case series study evaluated the MyGoals implementation strategies developed using Implementation Mapping (IM), specifically IM Task 5 – Implementation Outcome Evaluation. Seven OTs and 13 adults with chronic conditions participated in this study. OTs participated in twoClinician Educationsessions, delivered two MyGoals interventions, and participated in twoAudit & Feedbacksessions. We evaluated the implementation strategies using the Acceptability of Intervention Measure (AIM), Intervention Appropriateness Measure (IAM), Feasibility of Intervention Measure (FIM), and semi-structured interviews and explored the OTs' self-rated MyGoals change objectives achievement and the intervention fidelity using quantitative MyGoals intervention fidelity measures and interviews. Quantitative data were analyzed using descriptive statistics. Qualitative data were analyzed by two independent coders using content analysis.

Results

Seven OTs participated in this study (mean years of professional experience = 9.3, SD = 5.9).Clinician EducationandAudit & Feedbackhad high AIM (M = 17.9, SD = 2.7), IAM (M = 17.3, SD = 3.60), and FIM scores (M = 17.3, SD = 3). The OTs also had high mean scores on self-perceived achievement of change objectives and intervention fidelity. Qualitative interviews suggested that the time commitment forClinician Educationis a key barrier to its acceptability, appropriateness, and feasibility. Participants also provided suggestions on how to improve the strategies (e.g., providing recordedClinician Education, etc.).

Conclusions

The MyGoals implementation strategies are acceptable, appropriate, and feasible to OTs working in community-based rehabilitation. They support OTs in achieving the change objectives necessary to deliver MyGoals completely and competently. Thus, the MyGoals implementation strategies may support clinicians in implementing a theory-based, client-engaged goal setting and goal management for adults with chronic conditions in community-based rehabilitation. This can ultimately help improve the integration of evidence-based interventions into practice.
Unsupervised video anomaly detection in UAVs: a new approach based on learning and inference
Authors: Liu Gang , Shu Lisheng , Yang Yuhui , Jin Chen
Published: June 2023

In this paper, an innovative approach to detecting anomalous occurrences in video data without supervision is introduced, leveraging contextual data derived from visual characteristics and effectively addressing the semantic discrepancy that exists between visual information and the interpretation of atypical incidents. Our work incorporates Unmanned Aerial Vehicles (UAVs) to capture video data from a different perspective and to provide a unique set of visual features. Specifically, we put forward a technique for discerning context through scene comprehension, which entails the construction of a spatio-temporal contextual graph to represent various aspects of visual information. These aspects encompass the manifestation of objects, their interrelations within the spatio-temporal domain, and the categorization of the scenes captured by UAVs. To encode context information, we utilize Transformer with message passing for updating the graph's nodes and edges. Furthermore, we have designed a graph-oriented deep Variational Autoencoder (VAE) approach for unsupervised categorization of scenes, enabling the extraction of the spatio-temporal context graph across diverse settings. In conclusion, by utilizing contextual data, we ascertain anomaly scores at the frame-level to identify atypical occurrences. We assessed the efficacy of the suggested approach by employing it on a trio of intricate data collections, specifically, the UCF-Crime, Avenue, and ShanghaiTech datasets, which provided substantial evidence of the method's successful performance.
Laparoscopic uterosacral ligament suspension: a systematic review and meta-analysis of safety and durability
Authors: Ronsini Carlo , Pasanisi Francesca , Cianci Stefano , Vastarella Maria Giovanna , Pennacchio Marika , Torella Marco , Ercoli Alfredo , Colacurci Nicola
Published: June 2023

Introduction

Pelvic organ prolapse (POP) is a widespread condition affecting from 40% to 60% of women. Reconstructive vaginal surgeries are the most commonly performed procedures to treat POP. Among those, uterosacral ligament suspension (USLS), which is usually performed transvaginally, preserves pelvic statics and dynamics and appears to be an effective method. Laparoscopic USLS is a valid alternative to vaginal approach, and the aim of our review is to confirm its safety and feasibility and to compare clinical outcomes among the procedures.

Materials and methods

Following the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we systematically searched the PubMed and Scopus databases in December 2022. We made no restriction on the publication year nor on the country. Data about POP-Q recurrence rate (RR), intraoperative and postoperative complications (graded according to Clavien–Dindo classification), readmission rate, and reoperation rate were collected and analyzed. We used comparative studies for meta-analysis.

Results

A total of nine studies fulfilled inclusion criteria: two articles were non-comparative retrospective observational studies, three more articles were comparative studies where laparoscopic USLS was confronted with other surgical techniques (only data of laparoscopic USLS were analyzed), and four were comparative retrospective cohort studies between laparoscopic and vaginal USLS procedures. The comparative studies were enrolled in meta-analysis. Patients were analyzed concerning perioperative risks and the risk of recurrence. The meta-analysis highlighted that there was no clear inferiority of one technique over the other.

Discussion

Laparoscopic USLS is a technique with a low complication rate and low recurrence rate. Indeed, laparoscopic procedure allows better identification of anatomical landmarks and access to retroperitoneum. Moreover, efficacy over time and durability of Laparoscopic (LPS) USLS was also observed. However, these data should be weighed in light of the length of follow-up, which was in a very short range. Further, focused and prospective studies will be necessary to confirm this finding.
René-Édouard Claparède (1832–1871), Pioneer Protozoologist and Comparative Anatomist
Authors: Kollarou Penelope A. , Triarhou Lazaros C.
Published: June 2023

The pioneer Swiss naturalist René-Édouard Claparède (1832–1871), professor at the University of Geneva, left important contributions to diverse areas of natural science, biology, and comparative anatomy, including the structure of infusoria, annelids, and earthworms, the evolution of arthropods, and the embryology of spiders. He also published observations on marine invertebrates. This essay presents a brief overview of his academic life and work and makes the distinction from his nephew with the same name, the neurologist and educational psychologist Édouard Claparède (1873–1840).
Structural Stability and Surrounding Rock Integrity Analysis for Goaf-Side Entry with Small Coal Pillars in Longwall Mining
Authors: Zhao Yiming , Xiang Zhi
Published: June 2023

Goaf-side entry with small coal pillars (GESCPs) has an intrinsic advantage of improving the coal recovery ratio by implementing drifts with a small pillar size next to previous goafs. This technology is increasingly gaining popularity in the longwall mining of underground coal mines in China. This study focuses on understanding the critical condition of the main roof failure above the solid coal side of the goaf-side entry and investigating the key parameters that affect the structural stability of the surrounding rocks for GESCP. Mechanical models of the main roof and multi-layer cracking structures of the side wall of GESCP were established and the limiting equilibrium equation for the structural stability of the surrounding rock was proposed. The characteristics affecting the main parameters of the structural stability of the surrounding rock were analyzed. The research findings suggest that the integrity of the coal side walls plays a major role in maintaining the structural stability of the surrounding rock for GESCP under the given cross-sectional dimensions. Other factors, including the uniform load of overburden, the width of the coal pillar, the length of the roof hanging along the goaf side, and the fracture length in the main roof of the entry side wall, are less important. The key to achieving structural stability of the surrounding rocks for GESCP is to enhance the strength of the supporting coal side walls and, especially, to ensure the integrity of the small coal pillars. These conclusions were verified by engineering practice at the 1252(1) haulage gateway in a Coal Mine in China.
Three-Dimensional Distributions of the Direct Effect of anExtended and Intense Dust Aerosol Episode (16–18 June 2016) over the Mediterranean Basin on Regional Shortwave Radiation, Atmospheric Thermal Structure, and Dynamics
Authors: Gavrouzou Maria , Hatzianastassiou Nikos , Korras-Carraca Marios-Bruno , Stamatis Michalis , Lolis Christos , Matsoukas Christos , Michalopoulos Nikos , Vardavas Ilias
Published: June 2023

In the present study, we used the FORTH deterministic spectral Radiation Transfer Model (RTM) to estimate detailed three-dimensional distributions of the Direct Radiative Effects (DREs) and their consequent modification of the thermal structure of the regional atmosphere during an intense dust episode that took place from 16 to 18 June 2016 over the Mediterranean Basin (MB). The RTM operated on a 3-hourly temporal and 0.5 × 0.625° spatial resolution, using 3-D aerosol optical properties (i.e., aerosol optical depth, single scattering albedo, and asymmetry parameter) and other surface and atmospheric properties from the MERRA-2 reanalysis and cloud properties (i.e., cloud amount, cloud optical depth, and cloud top height) from the ISCCP-H dataset. The model ran with and without dust aerosols, yielding the upwelling and downwelling solar fluxes at the top of the atmosphere, in the atmosphere, and at the Earth’s surface as well as at 50 levels in the atmosphere. The dust direct radiative effect (DDRE) was estimated as the difference between the two (one taking into account all aerosol types and one taking into account all except for dust aerosols) flux outputs. The atmospheric heating rates and subsequent convection induced by dust radiative absorption were calculated at 50 levels to determine how the DDRE affects the thermal structure and dynamics of the atmosphere. The results showed that such a great and intense dust transport event significantly reduces the net surface solar radiation over the MB (by up to 62 W/m2 on a daily mean basis, and up to 200 W/m2 on an hourly basis, at 12:00 UTC) while increasing the atmospheric solar absorption (by up to 72 W/m2 daily and 187 W/m2 hourly, at 12:00 UTC). At the top of the atmosphere, both heating (over desert areas) and cooling (over oceanic and other continental areas) are observed due to the significantly different surface albedos. Transported dust causes considerable heating of the region’s atmosphere, which becomes maximum at altitudes where the dust loadings are highest (0.14 K/3 h on 17 June 2016, 12:00 UTC, at 3–5 km above sea level). The dust solar absorption and heating induce a buoyancy as strong as 0.014 m/s2, resulting in considerable changes in vertical air motions and possibly contributing to the formation of middle- and high-level clouds over the Mediterranean Basin.
Shape Memory Alloy Reinforced Self-Healing Metal Matrix Composites
Authors: Bellah Masum , Nosonovsky Michael , Rohatgi Pradeep
Published: June 2023

This paper reviews the synthesis, characterization, healing assessment, and mechanics of NiTi and other shape memory alloy (SMA)-reinforced self-healing metal matrix composites (SHMMCs). Challenges to synthesizing and characterizing the SMA-reinforced SHMMCs and the strategies followed to overcome those challenges are discussed. To design the SMA-reinforced SHMMCs, it is necessary to understand their microstructural evolution during melting and solidification. This requires the knowledge of the thermodynamics of phase diagrams and nonequilibrium solidification, which are presented in this paper for a model self-healing composite system. Healing assessment provides information about the autonomous and multicycle healing capability of synthesized SHMMCs, which ultimately determines their success. Different techniques to assess the degree of healing of SHMMCs are discussed in this paper. Strategies are explored to find the optimum volume fraction of SMA wires needed to yield the matrix and prevent damage to the SMA wires for the most effective healing. Finally, major challenges, knowledge gaps, and future research directions, including the need for autonomous and multicycle healing capability in SMA-reinforced SHMMCs, are outlined.
Recent Advances in Ionic Liquids—MOF Hybrid Electrolytes for Solid-State Electrolyte of Lithium Battery
Authors: Lin Ruifan , Jin Yingmin , Li Yumeng , Zhang Xuebai , Xiong Yueping
Published: June 2023

Li-ion batteries are currently considered promising energy storage devices for the future. However, the use of liquid electrolytes poses certain challenges, including lithium dendrite penetration and flammable liquid leakage. Encouragingly, solid electrolytes endowed with high stability and safety appear to be a potential solution to these problems. Among them, ionic liquids (ILs) packed in metal organic frameworks (MOFs), known as ILs@MOFs, have emerged as a hybrid solid-state material that possesses high conductivity, low flammability, and strong mechanical stability. ILs@MOFs plays a crucial role in forming a continuous interfacial conduction network, as well as providing internal ion conduction pathways through the ionic liquid. Hence, ILs@MOFs can not only act as a suitable ionic conduct main body, but also be used as an active filler in composite polymer electrolytes (CPEs) to meet the demand for higher conductivity and lower cost. This review focuses on the characteristic properties and the ion transport mechanism behind ILs@MOFs, highlighting the main problems of its applications. Moreover, this review presents an introduction of the advantages and applications of Ils@MOFs as fillers and the improvement directions are also discussed. In the conclusion, the challenges and suggestions for the future improvement of ILs@MOFs hybrid electrolytes are also prospected. Overall, this review demonstrates the application potential of ILs@MOFs as a hybrid electrolyte material in energy storage systems.
Model Predictive Control for Residential Battery Storage System: Profitability Analysis
Authors: Kobou Ngani Patrick , Hadji-Minaglou Jean-Régis
Published: June 2023

For increased penetration of energy production from renewable energy sources at a utility scale, battery storage systems (BSSs) are a must. Their levelized cost of electricity (LCOE) has drastically decreased over the last decade. Residential battery storage, mostly combined with photovoltaic (PV) panels, also follow this falling prices trend. The combined effect of the COVID-19 pandemic and the war in Ukraine has caused such a dramatic increase in electricity prices that many consumers have adjusted their strategies to become prosumers and self-sufficient as feed-in subsidies continue to drop. In this study, an investigation is conducted to determine how profitable it is to install BSSs in homes with regards to battery health and the levelized cost of total managed energy. This is performed using mixed-integer linear programming (MILP) in MATLAB, along with its embedded solver Intlinprog. The results show that a reasonable optimized yearly cycling rate of the BSS can be reached by simply considering a non-zero cost for energy cycling through the batteries. This cost is simply added to the electricity cost equation of standard optimization problems and ensures a very good usage rate of the batteries. The proposed control does not overreact to small electricity price variations until it is financially worth it. The trio composed of feed-in tariffs (FITs), electricity costs, and the LCOE of BSSs represents the most significant factors. Ancillary grid service provision can represent a substantial source of revenue for BSSs, besides FITs and avoided costs.
Environmentally Friendly New Catalyst Using Waste Alkaline Solution from Aluminum Production for the Synthesis of Biodiesel in Aqueous Medium
Authors: Barbosa Sandro L. , Nelson David Lee , Paconio Lucas , Pedro Moises , dos Santos Wallans Torres Pio , Wentz Alexandre P. , Pessoa Fernando L. P. , Agblevor Foster A. , Bortoleto Daniel A. , de Freitas-Marques Maria B. , Zanatta Lucas D.
Published: June 2023

Red mud (RM) is composed of a waste alkaline solution (pH = 13.3) obtained from the production of alumina. It contains high concentrations of hematite (Fe2O3), goethite (FeOOH), gibbsite [Al(OH)3], a boehmite (AlOOH), anatase (Tetragonal–TiO2), rutile (Ditetragonal dipyramidal–TiO2), hydrogarnets [Ca3Al2(SiO4)3−x(OH)4x], quartz (SiO2), and perovskite (CaTiO3). It was shown to be an excellent catalytic mixture for biodiesel production. To demonstrate the value of RM, an environmentally friendly process of transesterification in aqueous medium using waste cooking oil (WCO), MeOH, and waste alkaline solution (WAS) obtained from aluminum production was proposed. Triglycerides of WCO reacted with MeOH at 60 °C to yield mixtures of fatty acid methyl esters (FAMEs) in the presence of 0.019% (w/w) WAS/WCO using the WAS (0.204 mol L−1, predetermined by potentiometric titration) from aluminum production by the Bayer process. The use of the new catalyst (WAS) resulted in a high yield of the products (greater than 99% yield).
Stem Cell Therapy and Rejuvenation, and Their Impact on Society
Authors: Ibarretxe Gaskon
Published: June 2023

In his worldwide best-seller Homo Deus [...]
Ca2+ Influx through TRPC Channels Is Regulated by Homocysteine–Copper Complexes
Authors: Chen Gui-Lan , Zeng Bo , Jiang Hongni , Daskoulidou Nikoleta , Saurabh Rahul , Chitando Rumbidzai J. , Xu Shang-Zhong
Published: June 2023

An elevated level of circulating homocysteine (Hcy) has been regarded as an independent risk factor for cardiovascular disease; however, the clinical benefit of Hcy lowering-therapy is not satisfying. To explore potential unrevealed mechanisms, we investigated the roles of Ca2+ influx through TRPC channels and regulation by Hcy–copper complexes. Using primary cultured human aortic endothelial cells and HEK-293 T-REx cells with inducible TRPC gene expression, we found that Hcy increased the Ca2+ influx in vascular endothelial cells through the activation of TRPC4 and TRPC5. The activity of TRPC4 and TRPC5 was regulated by extracellular divalent copper (Cu2+) and Hcy. Hcy prevented channel activation by divalent copper, but monovalent copper (Cu+) had no effect on the TRPC channels. The glutamic acids (E542/E543) and the cysteine residue (C554) in the extracellular pore region of the TRPC4 channel mediated the effect of Hcy–copper complexes. The interaction of Hcy–copper significantly regulated endothelial proliferation, migration, and angiogenesis. Our results suggest that Hcy–copper complexes function as a new pair of endogenous regulators for TRPC channel activity. This finding gives a new understanding of the pathogenesis of hyperhomocysteinemia and may explain the unsatisfying clinical outcome of Hcy-lowering therapy and the potential benefit of copper-chelating therapy.
Converging Paths: A Comprehensive Review of the Synergistic Approach between Complementary Medicines and Western Medicine in Addressing COVID-19 in 2020
Authors: Moura Alexandra , Lopes Lara , Matos Luís Carlos , Machado Jorge , Criado Maria Begoña
Published: June 2023

The rapid spread of the new coronavirus disease (COVID-19) caused by SARS-CoV-2 has become a global pandemic. Although specific vaccines are available and natural drugs are being researched, supportive care and specific treatments to alleviate symptoms and improve patient quality of life remain critical. Chinese medicine (CM) has been employed in China due to the similarities between the epidemiology, genomics, and pathogenesis of SARS-CoV-2 and SARS-CoV. Moreover, the integration of other traditional oriental medical systems into the broader framework of integrative medicine can offer a powerful approach to managing the disease. Additionally, it has been reported that integrated medicine has better effects and does not increase adverse drug reactions in the context of COVID-19. This article examines preventive measures, potential infection mechanisms, and immune responses in Western medicine (WM), as well as the pathophysiology based on principles of complementary medicine (CM). The convergence between WM and CM approaches, such as the importance of maintaining a strong immune system and promoting preventive care measures, is also addressed. Current treatment options, traditional therapies, and classical prescriptions based on empirical knowledge are also explored, with individual patient circumstances taken into account. An analysis of the potential benefits and challenges associated with the integration of complementary and Western medicine (WM) in the treatment of COVID-19 can provide valuable guidance, enrichment, and empowerment for future research endeavors.
A Novel Urine Test Biosensor Platform for Early Lung Cancer Detection
Authors: Wiesel Ory , Sung Sook-Whan , Katz Amit , Leibowitz Raya , Bar Jair , Kamer Iris , Berger Itay , Nir-Ziv Inbal , Mark Danieli Michal
Published: June 2023

Lung cancer is the leading cause of cancer-related mortality worldwide. Early detection is essential to achieving a better outcome and prognosis. Volatile organic compounds (VOCs) reflect alterations in the pathophysiology and body metabolism processes, as shown in various types of cancers. The biosensor platform (BSP) urine test uses animals’ unique, proficient, and accurate ability to scent lung cancer VOCs. The BSP is a testing platform for the binary (negative/positive) recognition of the signature VOCs of lung cancer by trained and qualified Long–Evans rats as biosensors (BSs). The results of the current double-blind study show high accuracy in lung cancer VOC recognition, with 93% sensitivity and 91% specificity. The BSP test is safe, rapid, objective and can be performed repetitively, enabling periodic cancer monitoring as well as an aid to existing diagnostic methods. The future implementation of such urine tests as routine screening and monitoring tools has the potential to significantly increase detection rate as well as curability rates with lower healthcare expenditure. This paper offers a first instructive clinical platform utilizing VOC’s in urine for detection of lung cancer using the innovative BSP to deal with the pressing need for an early lung cancer detection test tool.
Improving Visual Working Memory with Cholinergic Deep Brain Stimulation
Authors: Bava Janki M. , Wang Zhengyang , Bick Sarah K. , Englot Dario J. , Constantinidis Christos
Published: June 2023

Acetylcholine is a critical modulatory neurotransmitter for cognitive function. Cholinergic drugs improve cognitive performance and enhance neuronal activity in the sensory and association cortices. An alternative means of improving cognitive function is through the use of deep brain stimulation. Prior animal studies have demonstrated that stimulation of the nucleus basalis of Meynert through DBS improves cognitive performance on a visual working memory task to the same degree as cholinesterase inhibitors. Additionally, unlike current pharmacological treatments for neurocognitive disorders, DBS does not lose efficacy over time and adverse effects are rare. These findings suggest that DBS may be a promising alternative for treating cognitive impairments in neurodegenerative disorders such as Alzheimer’s disease. Thus, further research and human trials should be considered to assess the potential of DBS as a therapeutic treatment for these disorders.
Role of Cue Training, Context, and Stimulus Intensity on Fear Generalization in Humans
Authors: Gao Yu , Zhao Shaochen , Yang Zifan , Fu Haote , Luo Keying , Chen Wei , Fan Min , Song Yidan , Zheng Xifu
Published: June 2023

Fear generalization is a crucial mechanism underlying maladaptive behavior, but factors influencing this process are not fully understood. We investigated the effects of cue training and context on fear generalization and how cognitive rules influence responses to different conditions. We also examined the role of stimulus intensity in fear generalization to provide insight into fear generalization mechanisms. Participants (n = 104) completed a fear emotion task with two stages: acquisition and generalization testing. Subjective fear expectancy ratings were used as outcome measures. Participants who received single threat cue training exhibited stronger fear generalization responses than those who received discrimination training with threat and safe cues. Participants who received discrimination training and used linear rules had the strongest fear response to the largest stimulus. Therefore, a safe cue may mitigate fear generalization but could increase fear responses to more intense stimuli. Altering context did not change the fear generalization response because fear generalization is mainly governed by the association between the conditioned stimulus and the unconditioned fear stimulus. The present study emphasizes the multifaceted nature of fear generalization and the importance of examining multiple factors to understand this phenomenon. These findings elucidate fear learning and provide insights needed for effective interventions for maladaptive behavior.
Rethinking the Heritage through a Modern and Contemporary Reinterpretation of Traditional Najd Architecture, Cultural Continuity in Riyadh
Authors: Moscatelli Monica
Published: June 2023

The expressiveness of architectural language in terms of the formal and aesthetic approach is a feature that should not be secondary in contemporary buildings. The surface, texture, form, representation, and expression should prevail over aesthetic purposes in architecture. This research aims to highlight how the plastic and expressive value of the traditional buildings in the Najd region of Saudi Arabia, rich in cultural heritage and building form, can be translated into contemporary ones, creating the continuity of the local cultural identity in a rapidly growing context. This research used a qualitative methodology based on selecting seven modern and contemporary case studies in Riyadh. The selected case studies were analyzed using four criteria: composition aspects, plastic figuration, expressive value, and context connection. The comparison of the case studies underlined the plasticity and malleability of the wall surfaces, the formal character, and the aesthetic approach, showing continuity with the cultural heritage of the Najd architecture. These examples demonstrate how architecture that is attentive to place and history, incorporating local materials and its cultural heritage, can represent an opportunity to rethink the constructive and aesthetic approach to provide guiding criteria for contemporary architects designing in the rapidly expanding city.
Kaempferol and Fisetin-Related Signaling Pathways Induce Apoptosis in Head and Neck Cancer Cells
Authors: Kubina Robert , Krzykawski Kamil , Dziedzic Arkadiusz , Kabała-Dzik Agata
Published: June 2023

Despite the relative effectiveness of standard cancer treatment strategies, head and neck cancer (HNC) is still considered one of the leading causes of mortality and morbidity. While selected bioactive compounds of plant origin reveal a pro-apoptotic effect, kaempferol and fisetin flavonols have been reported as potential anti-cancer agents against malignant neoplasms. To date, their exact role in signaling pathways of head and neck cancer cells is largely unknown. Based on the various methods of cytotoxicity testing, we elucidated that kaempferol and fisetin inhibit proliferation, reduce the capacity of cell migration, and induce apoptosis in SCC-9, SCC-25, and A-253 HNC cells in a dose-dependent manner in vitro (p < 0.05, fisetin IC50 values of 38.85 µM, 62.34 µM, and 49.21 µM, and 45.03 µM, 49.90 µM, and 47.49 µM for kaempferol–SCC-9, SCC-25, and A-253, respectively). The obtained results showed that exposure to kaempferol and fisetin reduces Bcl-2 protein expression, simultaneously leading to the arrest in the G2/M and S phases of the cell cycle. Kaempferol and fisetin inhibit cell proliferation by interfering with the cell cycle, which is strongly associated with the induction of G2/M arrest, and induce apoptosis by activating caspase-3 and releasing cytochrome c in human HNC cells. In addition, investigating flavonols, by inhibiting anti-apoptotic proteins from the Bcl-2 family and damaging the mitochondrial transmembrane potential, increased the level of cytochrome c. While flavonols selectively induce apoptosis of head and neck cancer cells, they may support oncological therapy as promising agents. The discovery of new derivatives may be a breakthrough in the search for effective chemotherapeutic agents with less toxicity and thus fewer side effects.
Non-Vesicular Release of Alarmin Prothymosin α Complex Associated with Annexin-2 Flop-Out
Authors: Ueda Hiroshi
Published: June 2023

Nuclear protein prothymosin α (ProTα) is a unique member of damage-associated molecular patterns (DAMPs)/alarmins. ProTα prevents neuronal necrosis by causing a cell death mode switch in serum-starving or ischemic/reperfusion models in vitro and in vivo. Underlying receptor mechanisms include Toll-like receptor 4 (TLR4) and Gi-coupled receptor. Recent studies have revealed that the mode of the fatal stress-induced extracellular release of nuclear ProTα from cortical neurons in primary cultures, astrocytes and C6 glioma cells has two steps: ATP loss-induced nuclear release and the Ca2+-mediated formation of a multiple protein complex and its extracellular release. Under the serum-starving condition, ProTα is diffused from the nucleus throughout the cell due to the ATP loss-induced impairment of importin α–mediated nuclear transport. Subsequent mechanisms are all Ca2+-dependent. They include the formation of a protein complex with ProTα, S100A13, p40 Syt-1 and Annexin A2 (ANXA2); the fusion of the protein complex to the plasma membrane via p40 Syt-1–Stx-1 interaction; and TMEM16F scramblase-mediated ANXA2 flop-out. Subsequently, the protein complex is extracellularly released, leaving ANXA2 on the outer cell surface. The ANXA2 is then flipped in by a force of ATP8A2 activity, and the non-vesicular release of protein complex is repeated. Thus, the ANXA2 flop-out could play key roles in a new type of non-vesicular and non-classical release for DAMPs/alarmins, which is distinct from the modes conducted via gasdermin D or mixed-lineage kinase domain-like pseudokinase pores.
Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair
Authors: Elia Andrea , Mohsin Sadia , Khan Mohsin
Published: June 2023

The adult heart is made up of cardiomyocytes (CMs) that maintain pump function but are unable to divide and form new myocytes in response to myocardial injury. In contrast, the developmental cardiac tissue is made up of proliferative CMs that regenerate injured myocardium. In mammals, CMs during development are diploid and mononucleated. In response to cardiac maturation, CMs undergo polyploidization and binucleation associated with CM functional changes. The transition from mononucleation to binucleation coincides with unique metabolic changes and shift in energy generation. Recent studies provide evidence that metabolic reprogramming promotes CM cell cycle reentry and changes in ploidy and nucleation state in the heart that together enhances cardiac structure and function after injury. This review summarizes current literature regarding changes in CM ploidy and nucleation during development, maturation and in response to cardiac injury. Importantly, how metabolism affects CM fate transition between mononucleation and binucleation and its impact on cell cycle progression, proliferation and ability to regenerate the heart will be discussed.
Oxytocin’s Regulation of Thermogenesis May Be the Link to Prader–Willi Syndrome
Authors: Camerino Claudia
Published: June 2023

Prader–Willi Syndrome (PWS) is a genetic neurodevelopmental disorder that is caused by either the deletion of the paternal allele of 15q11-q13, maternal uniparental disomy of chromosome 15 or defects in the chromosome 15 imprinting centre and is characterized by cognitive impairment, hyperphagia and low metabolic rate with significant risk of obesity, as well as a variety of other maladaptive behaviours and autistic spectrum disorder (ASD). Many of the features seen in PWS are thought to be due to hypothalamic dysfunction resulting in hormonal abnormalities and impaired social functioning. The preponderance of evidence indicates that the Oxytocin system is dysregulated in PWS individuals and that this neuropeptide pathways may provide promising targets for therapeutic intervention although the process by which this dysregulation occurs in PWS awaits mechanistic investigation. PWS individuals present abnormalities in thermoregulation an impaired detection for temperature change and altered perception of pain indicating an altered autonomic nervous system. Recent studies indicate that Oxytocin is involved in thermoregulation and pain perception. This review will describe the update on PWS and the recent discoveries on Oxytocin regulation of thermogenesis together with the potential link between Oxytocin regulation of thermogenesis and PWS to create a new groundwork for the treatment of this condition.
“The Key Is to Value Every Little Achievement”: A Qualitative Study of the Psychological Experience of Parent Caregivers in Paediatric Palliative Care
Authors: Nogueira Alexandra Jóni , Ribeiro Maria Teresa
Published: June 2023

In Europe, Portugal has been identified as the country with the most rapid evolution of paediatric palliative care provision, which is a highly complex experience for families. The present descriptive–exploratory study seeks to contribute to the understanding of the psychological experience of life-limiting conditions in parent caregivers. A total of 14 families completed a sociodemographic and clinical data sheet and answered a structured online interview based on an incomplete narrative resulting from the Unwanted Guest Metaphor. A thematic analysis of the various narratives was performed through an inductive–deductive process. The results provide a holistic view of 10 essential dimensions in the parental psychological experience and contribute to the design of intervention methodologies in an eco-systemic approach. The importance of clear communication with health professionals, an awareness of the unpredictability of the disease, the desire for more self-care, the difficulty in understanding their children’s needs and the threat implicit in everyday life are some of the main findings. This research emphasizes the importance of having opportunities of emotional expression and psychoeducation about anxiety’ management, enhancing the perception of positive characteristics in children with palliative needs and creating time for the couple. The study has some limitations, such as the small sample size, and suggests that further research should explore the father’s experience.
The Role of Serotonergic and Noradrenergic Descending Pathways on Performance-Based Cognitive Functioning at Rest and in Response to Exercise in People with Chronic Whiplash-Associated Disorders: A Randomized Controlled Crossover Study
Authors: Coppieters Iris , Nijs Jo , Meeus Mira , De Kooning Margot , Rheel Emma , Huysmans Eva , Pas Roselien , Van Bogaert Wouter , Hubloue Ives , Ickmans Kelly
Published: June 2023

(1) Background: Dysregulation in serotonergic and noradrenergic systems may be implicated in the neurobiophysiological mechanisms underlying pain-related cognitive impairment in chronic whiplash-associated disorders (CWAD). This study aimed to unravel the role of serotonergic and noradrenergic descending pathways in cognitive functioning at rest and in response to exercise in people with CWAD. (2) Methods: 25 people with CWAD were included in this double-blind, randomized, controlled crossover study. Endogenous descending serotonergic and noradrenergic inhibitory mechanisms were modulated by using a single dose of a selective serotonin reuptake inhibitor (Citalopram) or a selective norepinephrine reuptake inhibitor (Atomoxetine). Cognitive performance was studied at rest and in response to exercise (1) without medication intake; (2) after intake of Citalopram; and (3) after intake of Atomoxetine. (3) Results: After Atomoxetine intake, selective attention improved compared with the no medication day (p < 0.05). In contrast, a single dose of Citalopram had no significant effect on cognitive functioning at rest. When performing pairwise comparisons, improvements in selective attention were found after exercise for the no medication condition (p < 0.05). In contrast, after intake of Citalopram or Atomoxetine, selective and sustained attention worsened after exercise. (4) Conclusions: A single dose of Atomoxetine improved selective attention only in one Stroop condition, and a single dose of Citalopram had no effect on cognitive functioning at rest in people with CWAD. Only without medication intake did selective attention improve in response to exercise, whereas both centrally acting medications worsened cognitive performance in response to a submaximal aerobic exercise bout in people with CWAD.
Multicomponent Crystals of Phthalocyanines–A Possibility of Fine-Tuning Properties
Authors: Oluwole David O. , Báthori Nikoletta B.
Published: June 2023

Phthalocyanines (Pcs) are 18-electron π-conjugated macrocyclic ring systems with proven activities in diverse fields, including pharmaceuticals and catalysis. These demonstrated activities are often alluded to as their fascinating photophysical and photochemical dispositions, which are usually dependent on their molecular structures. However, many of these molecules suffer from aggregation due to π–π stacking and have limited insolubility in hydrophilic media, which limits their extensive utilisation in pharmaceutical applications. This review will explore the possibility of fine-tuning the physicochemical properties of phthalocyanines when designed as multicomponent crystals. Among the proven and SMART approaches that have been shown to enhance drug solubility without altering the molecular structure is co-crystallisation. This protocol involves the design and formation of non-covalent interactions between two or more molecular entities to create a supramolecular assembly and subsequently afford multicomponent crystals (MCCs). A systematic review of the Cambridge Structural Database repository yielded several single and multicomponent crystals of Pcs; however, most of them were either salts or solvates, with only a few reports on their co-crystals.
Genetic Testing for Familial Hypercholesterolemia in a Pediatric Group: A Romanian Showcase
Authors: Constantin Andreea Teodora , Streata Ioana , Covăcescu Mirela Silvia , Riza Anca Lelia , Roșca Ioana , Delia Corina , Tudor Lucia Maria , Dorobanțu Ștefania , Dragoș Adina , Ristea Diana , Ioana Mihai , Gherghina Ioan
Published: June 2023

Familial hypercholesterolemia (FH) is a genetic disease marked by high levels of LDL-cholesterol. This condition has long-term clinical implications, such as cardiovascular events, that are evident during adult life. Here, we report on a single-center cross-sectional showcase study of genetic testing for FH in a Romanian pediatric group. Genetic testing for FH was performed on 20 Romanian pediatric patients, 10 boys and 10 girls, admitted with LDL-cholesterol levels over 130 mg/mL to the National Institute for Mother and Child Health “Alesssandrescu-Rusescu” in 2020. Genetic testing was performed using the Illumina TruSight Cardio panel. We identified pathogenic/likely pathogenic variants that could explain the phenotype in 5/20 cases. The involved genes were LDLR and APOB. Clinical signs that suggest the diagnosis of FH are scarce for the pediatric patient, although it can be diagnosed early during childhood by lipid panel screening. Prevention could prove lifesaving for some of these patients.