bluuebunny/crossref_metadata_2025 huggingface dataset:
Climatology and pre-convection environmental conditions of dry and wet thunderstorm high winds over eastern China
Authors: Tian Fuyou , Zhang Xiaoling , Sun Jianhua , Xia Kun , Hua Shan , Wei Qian , Xue Lulin , Yang Bo
Published: October 2023

Thunderstorm high wind (THW) is defined as a kind of convective weather phenomenon with a maximum wind gust speed not less than 17.2 m·s−1 over China. It is a sudden, damaging, but common convective weather phenomenon during the warm seasons of China. By adopting a kernel density estimation (KDE) for the THWs during warm seasons (March–September) of 2010–2019 over eastern China and the European Centre for Medium-Range Weather Forecasts Reanalysis v5 (ERA5) dataset, the dry and wet THWs usually with different mechanisms are objectively obtained, and climatology and pre-convection environmental conditions investigated. KDE shows the total precipitable water (TPW) of 38 mm can be used as the threshold for distinguishing dry THWs from wet ones. Dry THWs mainly concentrate in North China and Yunnan province, while wet ones mainly concentrate in South China. West of Hebei province has high frequencies for both dry and wet THWs. A comparison of pre-convection environmental conditions shows dry THWs mainly occur under environmental conditions with lower saturation at both the middle-lower and upper layers, while wet ones usually have relatively lower saturation at the middle-lower layers. The instability of wet THWs can be well characterized by the most unstable lifted index (MULI) and most unstable convective available potential energy (MUCAPE), while dry ones can be well depicted by the lower 500 hPa temperature caused higher temperature difference (DT85) or temperature lapse rate (TLR85) between 850 and 500 hPa. The 0–6-km vertical wind shear (SHR6) can distinguish dry THWs from wet ones better than SHR1. The typical difference can be comprehensively revealed by the representative soundings. The results provide objective references for understanding and forecasting THWs under dry and wet environmental conditions.
A negotiation model of individual matching and zonal-based travel behavior in carpooling
Authors: Hussain Iftikhar , Janssens Davy , Elomri Adel , Niu Ben
Published: October 2023

Carpooling is a sustainable and ecologically acceptable transportation mode. Individuals commonly engage in coordination and negotiation processes to find matching partners and typically modify their schedules to enable cooperation. Mutual cooperation between carpooling individuals plays an important role in executing trips. Through cooperation, participants can achieve challenging agreements effectively in a repetitive manner. This paper presents a negotiation mechanism that can match individuals for carpooling using organization and agent-based concepts. It describes a matching model and a carpooling social network. It studies several aspects of multi-zonal individual behavior to identify groups of carpooling candidates. The carpooling social network is simulated on an ongoing basis for each of the following carpooling activities: interaction, negotiation, and trip execution. The interaction process enables communication between individuals within carpooling social groups in order to activate the negotiation process. During the negotiation process, participants typically modify their schedules to support cooperation by considering their personal preferences and constraints. Negotiation leads to matching of individuals based on trip start times, driver selection, detour duration, and carpool group pickup and dropoff sequences. Trip start times are established on travel, social, financial, and schedule-related factors. The carpoolers’ pickup and dropoff sequences that are feasible for an optimal carpool group are projected using specific scoring methods. Carpooling community candidates are recognized via outcomes projected using the FEATHERS activity–based model. The framework is implemented through the Janus multi-agent system.
Carbon Stocks and Transfers in Coniferous Boreal Forests Along a Latitudinal Gradient
Authors: Merilä Päivi , Lindroos Antti-Jussi , Helmisaari Heljä-Sisko , Hilli Sari , Nieminen Tiina M. , Nöjd Pekka , Rautio Pasi , Salemaa Maija , Ťupek Boris , Ukonmaanaho Liisa
Published: October 2023

Carbon (C) sequestrated in the boreal forest ecosystems plays an important role in climate regulation. This study’s objectives were to quantify the differences in the components of the forest C cycle along a 1000 km latitudinal gradient within the boreal region and between dominant coniferous species in Fennoscandia. The study included seven xeric–sub-xeric and eight mesic–herb-rich heath forests dominated by Scots pine and Norway spruce, respectively. The total site carbon stock (CS) ranged from 81 to 260 Mg ha−1. The largest ecosystem component CSs were tree stems, mineral soil, and humus layer, representing 30 ± 2%, 28 ± 2%, and 13 ± 1% of total CS, respectively. On average, the spruce sites had 40% more C than the pine sites, and CS stored in most compartments was higher on spruce than on pine sites. As exceptions, understorey vegetation and litter layer had a larger CS on pine than on spruce sites. The northern sites had an average of 58% less C than the southern sites. Humus layer CS was the only compartment showing no latitudinal trends. Northern sites had a significantly larger fine and small root CS and understorey CS than southern sites. Most CS compartments were significantly correlated with litterfall C transfer components. Dissolved organic carbon (DOC) flux in throughfall was positively correlated with the aboveground tree compartment CS. Our study revealed patterns of C distribution in major boreal forest ecosystems along latitudinal and fertility gradients, which may serve as a reference for Earth system models and in the evaluation of their projections.
Overview of new-onset refractory status epilepticus: current concepts, diagnosis, and management
Authors: Wickström Ronny
Published: October 2023

New-onset refractory status epilepticus (NORSE) is a rare and devastating condition presenting with refractory status epilepticus and often evolving into super-refractory status epilepticus. The poor outcome with a significant mortality rate and a high rate of morbidity among survivors of NORSE warrants awareness and early identification of the condition so as to initiate appropriate investigations and management. Although the pathophysiological mechanisms are unknown, inflammatory mechanisms including activation of innate immunity are likely involved. Treatment should therefore include aggressive escalation of antiseizure medications followed by early initiation of a ketogenic diet and immunomodulation. First-line immunotherapy should be initiated within 72 h of seizure onset, with a ketogenic diet and second-line immunomodulation being started in the first week if seizures remain. This article aims to review current knowledge on NORSE and to highlight specific areas including recent consensus definitions and Delphi-based recommendations as well as open registries for future research.
Application of Modified Atmospheres to Control Stegobium paniceum and Lasioderma serricorne Infestation of Stored Chamomile and Coriander and Its Effect On Product Quality
Authors: Hashem Mohamed Y. , Ahmed Sayeda S. , Khalil Shimaa S. H. , El-Attar Asmaa B. , Abdelgawad Karima F.
Published: October 2023

Medicinal and spices plants are crucial, and they can become infested by several insects, such as drugstore beetle (Stegobium paniceum l.) and the cigarette beetle (Lasioderma serricorne), during storage. Therefore, the present study aimed to assess the effect of enriched modified atmospheres (MAs), with CO2or N2, onL. serricorneandS. paniceumadults and larvae and their effect on quality of chamomile flowers and coriander seeds during storage. Various carbon dioxide and nitrogen gas concentrations were tested, including 40% CO2, 50% CO2, 60% CO2, 97% N2, and 98% N2. The larval mortality forS. paniceumreached 100% after 6 days of 60% CO2and 8 days for theL. serricorne. At 98% N2treatment, the complete mortality (100%) ofS. paniceumandL. serricorneadults was recorded following 3 and 9 day exposures and of larvae following 10 day exposure.

The quality parameters (weight loss percentage, germination, essential oil percentage, and color) of chamomile flower and coriander seeds treated with 60% CO2and control were studied after 3 and 6 months of storage. The MAs had the lowest weight loss percentage, the highest lightness value, the lowest color changes, and the highest essential oil content of chamomile flower and coriander seeds compared with the control treatment. Additionally, the MAs induced a higher germination percentage of coriander seeds compared with the control. Treatment with CO2increased some essential oils compounds, compared with control after 6 months of storage of chamomile. All compounds were decreased in coriander seeds treated with CO2, except for carvone and anethole, which were increased. In conclusion, our study recommends using MAs to controlS. paniceumandL. serricorneduring storage and maintain the quality of chamomile flower and coriander seed.
Parent Involvement in Mental Health Treatment for Autistic Children: A Grounded Theory-Informed Qualitative Analysis
Authors: Chan Victoria , Albaum Carly S. , Khanlou Nazilla , Westra Henny , Weiss Jonathan A.
Published: October 2023

Cognitive behavior therapy (CBT) is an effective treatment for many autistic children experiencing mental health problems, and parents are particularly involved in their psychotherapy. This study presents a conceptual framework of successful parent involvement in CBT for autistic children. Seventeen therapists (94% female) and 11 mothers were interviewed about their involvement in a CBT program for autistic children ages 8–13 years. The conceptual framework depicts how parent involvement varies depending on child, parent, and environmental factors. Parents’ contributions to therapy were grouped into five main roles. Parents’ beliefs and attitudes toward therapy also influenced their involvement. This is the first study to empirically investigate how parents of autistic children contribute to the therapeutic process in CBT.
Coffee fruit rot in Puerto Rico: distribution, ecology and associated fungi
Authors: Caldwell Maylin Y. , Mariño Yobana A. , Medina Ana G. , Serrato-Díaz Luz M. , Bayman Paul
Published: October 2023

Anthracnose of coffee fruits caused by Colletotrichum species is responsible for major losses in coffee production worldwide. In most coffee-producing countries, this disease has been present for many years. Recently coffee fruit rot (CFR), a disease complex of Colletotrichum spp. and Fusarium spp. as casual agents, was described in Puerto Rico but it has not yet been quantified. This study surveys incidence and severity of CFR, correlates it to elevation, cultivation methods (full sun, shade or intercalated with taller plants) and the presence of the coffee berry borer (CBB), and identifies rot-associated fungi. We found that CFR is present throughout Puerto Rico at varying levels and that environmental and cultivation factors are associated with CFR incidence and severity. Specifically, increased altitude and shade correlated with lower CFR incidence. In addition, fruits damaged by the CBB were found to have significantly more disease than undamaged fruits. Lastly, we isolated 7 fungal genera associated with CFR, the most prevalent being Colletotrichum and Fusarium. Overall, this study suggests that planting coffee at higher altitude under shade and controlling CBB can reduce CFR.
Electrocardiographic abnormalities in patients with cardiomyopathies
Authors: Aimo Alberto , Milandri Agnese , Barison Andrea , Pezzato Andrea , Morfino Paolo , Vergaro Giuseppe , Merlo Marco , Argirò Alessia , Olivotto Iacopo , Emdin Michele , Finocchiaro Gherardo , Sinagra Gianfranco , Elliott Perry , Rapezzi Claudio
Published: October 2023

Abnormalities in impulse generation and transmission are among the first signs of cardiac remodeling in cardiomyopathies. Accordingly, 12-lead electrocardiogram (ECG) of patients with cardiomyopathies may show multiple abnormalities. Some findings are suggestive of specific disorders, such as the discrepancy between QRS voltages and left ventricular (LV) mass for cardiac amyloidosis or the inverted T waves in the right precordial leads for arrhythmogenic cardiomyopathy. Other findings are less sensitive and/or specific, but may orient toward a specific diagnosis in a patient with a specific phenotype, such as an increased LV wall thickness or a dilated LV. A “cardiomyopathy-oriented” mindset to ECG reading is important to detect the possible signs of an underlying cardiomyopathy and to interpret correctly the meaning of these alterations, which differs in patients with cardiomyopathies or other conditions.

Graphical abstract
Callous-unemotional Traits and Child Response to Teacher Rewards, Discipline, and Instructional Methods in Chinese Preschools: A Classroom Observation Study
Authors: Cao Xinyi , Somerville Matthew P. , Shou Yiyun , Xue Zijing , Allen Jennifer L.
Published: October 2023

Atypical responses to teacher rewards, discipline and different forms of instructional methods have been identified as potential contributors to disruptive behavior, low school engagement, and academic underachievement in children with elevated callous-unemotional (CU) traits. To date, research on CU traits in schools has relied on interview or questionnaire methods and has predominantly been conducted in Western countries. Thus, the present study aims to investigate the relationships between CU traits and children’s responses to teacher rewards, discipline and instructional methods in the Chinese preschool context using classroom observation. Eight teachers (7 females, 1 male; M = 37.66 years) and 116 children (56% girls; M = 5.16 years) from two mainstream Chinese preschools participated in the study. Of the 116 eligible children, the behavior of 108 children from four classes were observed during classroom activities. Findings indicated that CU traits were not related to children’s responses to discipline, nor did CU traits moderate the relationship between instructional methods and children’s academic engagement. Higher CU traits predicted a greater frequency of one-to-one teacher-child interaction. Our findings offer initial insights into the potential of early school-based interventions in fostering engagement and prosocial behavior among children with CU traits. However, they also highlight the need for additional support for preschool teachers, who face the challenge of managing these high-risk children who appear to require more individual time and attention.
Wellness Tour for Tribal Communities During the COVID-19 Pandemic: Uniting Sacred Space with Western Medicine to Prevent Substance Use
Authors: Wakhlu Nausheen , Soto Claradina , Duncan Mike , Titman Albert , Turner Barbara J.
Published: October 2023

Substance use disorders (SUD) and overdose deaths worsened further during the Covid-19 pandemic in American Indian and Alaska Native (AIAN) communities. The Native Dad’s Network (NDN) delivered the Wellness Tour, offering cultural activities and SUD prevention education, from March 2021 to June 2022, to 11 AIAN tribal communities across California. The in-person program created a “sacred space” through culturally congruent song, dance, and prayer. SUD education included: a lecture about opioids and SUD; group talking circles; an educational skit led by adolescents; and training in naloxone and fentanyl testing strip use along with supplies. After the day-long program, 341 participants agreed strongly on a 5-point Likert type question that it improved their quality of life (mean = 4.7). Among 243 respondents, agreement was strong (mean = 4.8) to two Likert-type questions about cultural relevance and confidence in using naloxone. This AIAN-led program adopted safe practices during the pandemic to deliver culturally congruent SUD prevention education to severely affected AIAN communities.
Assessing the Feasibility of Partnering with a Home Visiting Program for Early Childhood Obesity Prevention
Authors: Kapp Julie M. , Hall Brian , Kemner Allison
Published: October 2023

Purpose

Little empirical data exists evaluating the feasibility of partnering with established home visiting programs to implement early childhood obesity prevention programs, despite the recommendation to do so. To inform this gap, we evaluated the feasibility of collecting anthropometric measurements of children by home visitors across multiple sites, and the alignment of these measurements with children in need, including with adverse family experiences (AFEs) given emerging evidence suggests an association with childhood obesity.

Description

Our proof-of-concept study included primary data collection of child anthropometric measurements through an established home visiting program in four states. This sample included 248 children ages 6 months to 5 years.

Assessment

In the sample, 37.1% of the children had overweight or obesity, 50% were female, 64.2% Hispanic/Latinx, 15.8% non-Hispanic Black, and 42.3% from rural/small towns. Households included substantial needs: 87.1% were low income, 73.8% low education, and 59.3% underemployment. Regarding AFEs, 38.3% of the children had at least one, with the most common being mothers who were treated violently. A multivariable model revealed community type, not AFEs, was significantly associated with overweight/obesity status, suggesting children in suburban and especially rural/small town residences (odds ratio 5.11; 95% CI [1.59, 16.39]) could be priority populations for childhood obesity prevention programs.

Conclusion

Findings of this multi-site study inform the feasibility of partnering with home visiting programs to reach and measure a diverse sample of children and families in need of childhood obesity prevention.
Biological perspectives in geotechnics: theoretical developments
Authors: Jain Surabhi , Mishra Partha Narayan , Tiwari Satyam , Wang Yijie , Jiang Ningjun , Dash Hirak Ranjan , Chang Ilhan , Kumar Ashutosh , Das Sarat Kumar , Scheuermann Alexander , Bore Thierry
Published: October 2023

The interaction of bio–geosphere dates to the formation of first unicellular microbes on earth. However, it is only relatively recently that the complex biological interactions are observed, characterised, and simulated for its use in the domain of geotechnical engineering. Also, many bioinspired approaches have been utilised in computational geotechnics for optimisation and data analysis process. The living phase present in the soil system hold a bearing on the majority of geochemical reactions and assist in modifying its fundamental and engineering behaviour. It necessitates revaluation and rescrutinisation of the conventional theories and formulations in geotechnical engineering, where soil has always been considered as an inert engineering material from biological perspective. To that end, this manuscript provides a critical review on biological approaches used in geotechnical engineering by highlighting the ongoing developments, achievements, and challenges to implement the processes. The review further emphasises the role of biological systems on the alteration of fundamental properties of soils and their consequences on effective stress, strength and stiffness, volume change and conduction properties of soils. Overall, the manuscript provides a basic understanding on the biological intervention in the soil system and the importance of consideration of the fourth phase in the soil system, i.e., the living phase, while describing such interventions.
How to make (mathematical) assertions with directives
Authors: Caponetto Laura , San Mauro Luca , Venturi Giorgio
Published: October 2023

It is prima facie uncontroversial that the justification of an assertion amounts to a collection of other (inferentially related) assertions. In this paper, we point at a class of assertions, i.e. mathematical assertions, that appear to systematically flout this principle. To justify a mathematical assertion (e.g. a theorem) is to provide a proof—and proofs are sequences of directives. The claim is backed up by linguistic data on the use of imperatives in proofs, and by a pragmatic analysis of theorems and their proofs. Proofs, we argue, are sequences of instructions whose performance inevitably gets one to truth. It follows that a felicitous theorem, i.e. a theorem that has been correctly proven, is a persuasive theorem. When it comes to mathematical assertions, there is no sharp distinction between illocutionary and perlocutionary success.
Truth and its uses: deflationism and alethic pluralism
Authors: Kaspers Tom
Published: October 2023

Deflationists believe that the question “What is truth?” should be answered not by means of a metaphysical inquiry into the nature of truth, but by figuring out what use we make of the concept of truth, and the word ‘true’, in practice. This article accepts this methodology, and it thereby rejects pluralism about truth that is driven by ontological considerations. However, it shows that there are practical considerations for a pluralism about truth, formulated at the level of use. The theory expounded by this article states that truth is a dual-purpose tool; it can be used as a device for transferring justificatory burdens and, for select areas of discourse, it can also be used as a standard, a norm. This contrast in how truth is used introduces a bifurcation in our discourse that is reminiscent of metaphysical divides traced by more traditional versions of alethic pluralism. However, my pluralism “at the level of use” states that truth is plural solely at the level of use. It is unified at both the conceptual as well as the metaphysical level. At those levels, the theory takes its cue from deflationism. As such, this theory is offered as a midway point and as a potential way forward in the debate between deflationism and pluralism.
Implicit bias as unintentional discrimination
Authors: Asma Lieke Joske Franci
Published: October 2023

In this paper, I argue that instead of primarily paying attention to the nature of implicit attitudes that are taken to cause implicit discrimination, we should investigate how discrimination can be implicit in itself. I propose to characterize implicit discrimination as unintentional discrimination: the person responds to facts unintentionally and often unconsciously which are, given their end, irrelevant and imply unfair treatment. The result is a unified account of implicit bias that allows for the different ways in which it can display itself and can be explained. Furthermore, the view can account for the central characteristics of implicit bias: (1) that it is, for a variety of reasons, difficult to control, (2) that we are not necessarily unconscious of implicit bias but not properly conscious either, and (3) that we can unintentionally discriminate regardless of whether we claim to care about fairness.
Evaluation of the significance of complement-related genes mutations in atypical postinfectious glomerulonephritis: a pilot study
Authors: Xu Feng , Zhang Changming , Zhang Mingchao , Zhu Xiaodong , Cheng Shuiqin , Cheng Zhen , Zeng Caihong , Jiang Song
Published: October 2023

Background

Postinfectious glomerulonephritis with C3-dominant glomerular deposition (C3-PIGN) involves C3-dominant glomerular deposition without immunoglobulin. Atypical C3-PIGN involves persistent hypocomplementemia. We investigated the clinical features and explored complement-related gene mutations in atypical PIGN patients.

Methods

We enrolled atypical C3-PIGN patients and collected data regarding the clinical presentation and pathological characteristics and follow-up data. We measured the levels of complement associated antibodies and performed whole-exome sequencing (WES) to detect mutations in complement-related genes.

Results

The analysis included six atypical C3-PIGN patients. All patients were antistreptolysin-O (ASO) positive. All patients had varying degrees of hematuria, and four patients had proteinuria. None of the patients were positive for complement-related antibodies. All patients possessed mutations of genes related to the complement pathway, including alternative complement pathway genes—CFI, CFH, CFHR3, CFHR5; the lectin pathway gene—MASP2; and the common complement pathway gene—C8A. The rare variant of CFHR3 has been reported in C3 glomerulonephritis. During 56–73 months of follow-up, the levels of urine markers in three patients recovered within 6 months, and the remaining patients had abnormal urine test results over 12 months. Patients who received glucocorticoid therapy recovered faster.

Conclusions

Our study suggested that complement-related gene mutations may be an important cause of persistent hypocomplementemia in atypical C3-PIGN patients. In addition to variations in alternate pathway-related genes, we also found variations in lectin pathway-related genes, especially MASP2 genes. Although the overall prognosis was good, atypical C3-PIGN patients exhibited a longer period for recovery. Our results suggested that atypical C3-PIGN patients should receive more medical attention and need testing for mutations in complement-related genes.
Life cycle assessment of a marine biorefinery producing protein, bioactives and polymeric packaging material
Authors: Amponsah Lorraine , Chuck Christopher , Parsons Sophie
Published: October 2023

Purpose

Algal research has been dominated by the use of marine biomass (mainly microalgae) as feedstock in the production of second-generation biofuels, albeit with limited economic success. A promising alternative strategy is the valorisation of seaweed (macroalgae), with the cascaded extraction of its high-value components, as well as lower-value components further downstream, under the ‘biorefinery concept’. The goal of this study was to assess the environmental performance of one such marine biorefinery situated in the UK.

Methods

Attributional life cycle assessment (LCA) was conducted on a hypothetical marine biorefinery coproducing fucoidan, laminarin, protein and alginate/cellulose packaging material (target product), from cultivated Saccharina latissima. The functional unit was the production of 1 kg of packaging material. A total of 6 scenarios were modelled, varying in coproduct management methodology (system expansion, mass allocation or economic allocation) and applied energy mix (standard or green energy). Sensitivity analysis was also conducted, evaluating the systems response to changes in allocation methodology; product market value; biomass composition and transport mode and distance. LCA calculations were performed using OpenLCA (version 1.10.3) software, with background processes modelled using the imported Ecoinvent 3.6 database. Environmental impacts were quantified under ReCiPe methodology at the midpoint level, from the ‘Heirarchist’ (H) perspective.

Results and discussion

The overall global warming impacts ranged from 1.2 to 4.52 kg CO2 eq/kg biopolymer, with the application of economic allocation; 3.58 to 7.06 kg CO2eq/kg with mass allocation and 14.19 to 41.52 kg CO2eq/kg with system expansion — the lower limit representing the instance where green electricity is used and the upper where standard electricity is employed. While implementing the green energy mix resulted in a 67% reduction in global warming impacts, it also incurred a 2–9 fold increase in overall impacts in the categories of terrestrial acidification, human non-carcinogenic toxicity, land-use and terrestrial ecotoxicity. Economic allocation resulted in burden shifting most favourable to the packaging material pathway.

Conclusions

This study demonstrates that the road to environmental optimisation in marine biorefineries is fraught with trade-offs. From the perspective of LCA — and by extension, the eco-design process that LCA is used to inform — when evaluating such product systems, it serves to strike a balance between performance across a broad spectrum of environmental impact categories, along with having consideration for the nature of energy systems incorporated and LCA methodological elements.

Graphical Abstract
Does analysts’ industrial concentration affect the quality of their forecasts?
Authors: He Guanming , Sun Yun , Li April Zhichao
Published: October 2023

We examine the association between financial analysts’ industrial concentration and the quality of their earnings forecasts. We find that analysts’ forecast quality, measured by forecast accuracy, forecast informativeness, and forecast timeliness, is positively associated with analysts’ industrial concentration on firm coverage, suggesting that allocation of effort and resources to the concentrated industries helps promote the quality of earnings forecasts. We also find that the positive relation of analysts’ industrial concentration with forecast accuracy and informativeness (forecast timeliness) is more (less) pronounced for firms faced with fiercer industrial product market competition, higher firm-specific risk, and/or higher information opacity. Overall, our results highlight the importance of analysts’ industrial concentration in contributing to the quality of their earnings forecasts.
Sharing rivals, sending weapons: Rivalry and cooperation in the international arms trade, 1920–1939
Authors: Mehrl Marius , Seussler Daniel , Thurner Paul W.
Published: October 2023

States must navigate the structure of the international system in their relations with other states. One crucial component of this structure are rivalries as they indicate latent threat to states. Rivalries should thus influence how states behave within the given system, but also how they seek to shape and restructure it. Focusing on arms transfers, we clarify how the systemic structure implied by rivalries drives states’ efforts to engage in security cooperation with other states. Intuitively, a rivalry with another country should diminish an exporter’s propensity to transfer weapons there. But what is more, we argue that rivalries outside of this focal dyad matter as a potential importer’s enmity towards other countries will reveal information about its security interests to the exporter. Specifically, sharing rivalries with the same set of countries will signal to the exporter that there is a congruence in security interests and thus facilitate security cooperation. This security cooperation should take the form of arms transfers, at least if exporters value buck-passing and fear entrapment. We test our expectations using original data on Major Conventional Weapons transfers in the Interwar years, a period where this condition likely holds, and inferential network analysis models. Sharing rivals increases two countries’ probability to trade arms whereas a rivalry between countries exhibits no effect. This research contributes to our understanding of security cooperation, the arms trade, and networked international relations.
Long-term Outcomes of Laparoscopic Sleeve Gastrectomy as a Revisional Procedure Following Adjustable Gastric Banding: Variations in Outcomes Based on Indication
Authors: Wickremasinghe Anagi , Leang Yit , Johari Yazmin , Chana Prem , Alderuccio Megan , Shaw Kalai , Laurie Cheryl , Nottle Peter , Brown Wendy , Burton Paul
Published: October 2023

Background

Significant controversy exists regarding the indications and outcomes after laparoscopic adjustable gastric banding (LAGB) conversions to laparoscopic sleeve gastrectomy (LSG).

Aim

To comprehensively determine the long-term outcomes of sleeve gastrectomy as a revisional procedure after LAGB across a range of measures and determine predictors of outcomes.

Methods

Six hundred revision LSG (RLSG) and 1200 controls (primary LSG (PLSG)) were included. Patient demographics, complications, follow-up, and patient-completed questionnaires were collected.

Results

RLSG vs controls; females 87% vs 78.8%, age 45 ± 19.4 vs 40.6 ± 10.6 years, p = 0.561; baseline weight 119.7 ± 26.2 vs 120.6 ± 26.5 kg p = 0.961). Follow-up was 87% vs 89.3%. Weight loss in RLSG at 5 years, 22.9% vs 29.6% TBWL, p = 0.001, 10 years: 19.5% vs 27% TBWL, p = 0.001. RLSG had more complications (4.8 vs 2.0% RR 2.4, p = 0.001), re-admissions (4.3 vs 2.4% RR 1.8, p = 0.012), staple line leaks (2.5 vs 0.9%, p = 0.003). Eroded bands and baseline weight were independent predictors of complications after RLSG. Long-term re-operation rate was 7.3% for RLSG compared to 3.2% in controls. Severe oesophageal dysmotility predicted poor weight loss. RLSG reported lower quality of life scores (SF-12 physical component scores 75.9 vs 88%, p = 0.001), satisfaction (69 vs 93%, p = 0.001) and more frequent regurgitation (58% vs 42%, p = 0.034).

Conclusion

RLSG provides long-term weight loss, although peri-operative complications are significantly elevated compared to PLSG. Longer-term re-operation rates are elevated compared to PLSG. Four variables predicted worse outcomes: eroded band, multiple prior bands, severe oesophageal dysmotility and elevated baseline weight.

Graphical Abstract
Association Between Monocyte-to-Lymphocyte Ratio and Hematoma Progression After Cerebral Contusion
Authors: Zhang Huajun , Duan Xiaochun , Zhang Yimiao , Zhuang Guoquan , Cao Demao , Meng Wei , Yan Muyang , Qi Wentao
Published: October 2023

Background

The objective of this research was to examine the impact of the monocyte-to-lymphocyte ratio (MLR) on the advancement of hematoma after cerebral contusion.

Methods

The clinical information and laboratory test findings of people with cerebral contusion were retrospectively analyzed. Using the tertiles of MLR, the study participants were categorized into three groups, enabling the evaluation of the correlation between MLR and the advancement of hematoma after cerebral contusion.

Results

Among the cohort of patients showing progression, MLR levels were significantly higher compared with the nonprogress group (P < 0.001). The high MLR group had a significantly higher proportion of patients with hematoma progression compared with the medium and low MLR groups. However, the medium MLR group had a lower proportion of patients with hematoma progression compared with the low MLR group. High MLR levels were independently linked to a higher risk of hematoma progression (Odds Ratio 3.546, 95% Confidence Interval 1.187–10.597, P = 0.024). By incorporating factors such as Glasgow Coma Scale score on admission, anticoagulant/antiplatelet therapy, white blood cell count, and MLR into the model, the predictive performance of the model significantly improved (area under the curve 0.754).

Conclusions

Our study suggests that MLR may serve as a potential indicator for predicting the progression of hematoma after cerebral contusion. Further research is necessary to investigate the underlying pathological and physiological mechanisms that contribute to the association between MLR and the progression of hematoma after cerebral contusion and to explore its clinical implications.
Shapley-based risk rankings: some theoretical considerations
Authors: Hiller Tobias
Published: October 2023

In this note, we enhance the analysis done by Auer and Hiller (Int J Finance Econ 24(2):884–889, 2019; Manag Decis Econ 42(4):876–884, 2021). Whereas their articles uses several simulation settings to illustrate that cooperative game theory may have the potential to solve the low-risk puzzle, we calculate for the three-asset case the conditions for partial ranking corrections between assets. Hence, our note could be interpreted as theoretical counterpart to Auer and Hiller (Int J Finance Econ 24(2):884–889, 2019; Manag Decis Econ 42(4):876–884, 2021).
Tailoring porous organic polymers with enhanced capacity, thermal stability and surface area for perfluorooctane sulfonic acid (PFOS) elimination from water environment
Authors: Elboughdiri Noureddine , Amari Abdelfattah , Harharah Hamed N. , Al-Ansari Nadhir , Sammen Saad Sh.
Published: October 2023

Perfluorooctane sulfonic acid (PFOS), a perfluoroalkyl substance, has engendered alarm over its presence in water sources due to its intrinsic toxicity. Hence, there is a pressing need to identify efficacious adsorbents capable of removing PFAS derivatives from water. To achieve this, batch adsorption studies under various circumstances were employed to tune amorphous polymer networks regarding their morphological configuration, heat durability, surface area and capacity to adsorb PFOS in water. A facile, one-pot nucleophilic substitution reaction was employed to synthesize amorphous polymer networks using triazine derivatives as building units for monomers. Notably, POP-3 exhibited a superlative adsorption capacity, with a removal efficiency of 97.8%, compared to 90.3% for POP-7. POP-7 exhibited a higher specific surface area (SBET) of 232 m2 g−1 compared to POP-3 with a surface area of 5.2 m2 g−1. Additionally, the study emphasizes the importance of electrostatic forces in PFOS adsorption, with pH being a significant element, as seen by changes in the PFOS sorption process by both polymeric networks under neutral, basic and acidic environments. The optimal pH value for the PFOS removal process using both polymers was found to be 4. Also, POP-7 exhibited a better thermal stability performance (300 °C) compared to POP-3 (190 °C). Finally, these findings indicate the ease with which amorphous polymeric frameworks may be synthesized as robust and effective adsorbents for the elimination of PFOS from waterbodies.
Laparoscopic approach in the management of diaphragmatic eventration in adults: gastrointestinal surgical perspective
Authors: El-Magd El-Sayed Abou , Elgeidie Ahmed , abbas Amr , Elmahdy Youssif , LotfyAbulazm Ibrahem , Hamed Hosam
Published: October 2023

The current literature is poor with studies handling the role of laparoscopy in managing diaphragmatic eventration (DE). Herein, we describe our experience regarding the role of laparoscopy in managing DE patients presenting mainly with gastrointestinal symptoms. We retrospectively reviewed the data of 20 patients who underwent laparoscopic diaphragmatic plication between January 2010 and December 2018. Postoperative outcomes and quality of life were assessed. Most DEs were left sided (95%). Laparoscopic diaphragmatic plication was possible in all patients, along with correcting all associated gastrointestinal and diaphragmatic problems. The former included gastric volvulus (60%), reflux esophagitis (25%), cholelithiasis (5%), and pyloric obstruction (5%), while the latter included diaphragmatic and hiatus hernia (10% and 15%, respectively).The average operative time was 142 min. All patients had a regular (reviewer #1) postoperative course except for one who developed hydro-pneumothorax. At a median follow-up of 48 months, midterm outcomes were satisfactory, with an improvement (reviewer #1) in gastrointestinal symptoms. Three patients (reviewer #1) developed radiological recurrence without significant clinical symptoms. Patient’s quality of life, including all parameters, significantly improved after the laparoscopic procedure compared to the preoperative values. Laparoscopic approach is safe and effective for managing adult diaphragmatic eventration (reviewer #1).
High-plex spatial transcriptomic profiling reveals distinct immune components and the HLA class I/DNMT3A/CD8 modulatory axis in mismatch repair-deficient endometrial cancer
Authors: Guo Jingjing , Tang Baijie , Fu Jing , Zhu Xuan , Xie Wenlong , Wang Nan , Ding Zhiyong , Song Zhentao , Yang Yue , Xu Gang , Xiao Xue
Published: October 2023

Purpose

Tumors bearing mismatch repair deficiency (MMRd) are characterized by a high load of neoantigens and are believed to trigger immunogenic reactions upon immune checkpoint blockade treatment such as anti-PD-1/PD-L1 therapy. However, the mechanisms are still ill-defined, as multiple cancers with MMRd exhibit variable responses to immune checkpoint inhibitors (ICIs). In endometrial cancer (EC), a distinct tumor microenvironment (TME) exists that may correspond to treatment-related efficacies. We aimed to characterize EC patients with aberrant MMR pathways to identify molecular subtypes predisposed to respond to ICI therapies.

Methods

We applied digital spatial profiling, a high-plex spatial transcriptomic approach covering over 1,800 genes, to obtain a highly resolved TME landscape in 45 MMRd-EC patients. We cross-validated multiple biomarkers identified using immunohistochemistry and multiplexed immunofluorescence using in-study and independent cohorts totaling 123 MMRd-EC patients and validated our findings using external TCGA data from microsatellite instability endometrial cancer (MSI-EC) patients.

Results

High-plex spatial profiling identified a 14-gene signature in the MMRd tumor-enriched regions stratifying tumors into “hot”, “intermediate” and “cold” groups according to their distinct immune profiles, a finding highly consistent with the corresponding CD8 + T-cell infiltration status. Our validation studies further corroborated an existing coregulatory network involving HLA class I and DNMT3A potentially bridged through dynamic crosstalk incorporating CCL5.

Conclusion

Our study confirmed the heterogeneous TME status within MMRd-ECs and showed that these ECs can be stratified based on potential biomarkers such as HLA class I, DNMT3A and CD8 in pathological settings for improved ICI therapeutic efficacy in this subset of patients.
Concurrent Strength and Endurance Training: A Systematic Review and Meta-Analysis on the Impact of Sex and Training Status
Authors: Huiberts Raven O. , Wüst Rob C. I. , van der Zwaard Stephan
Published: October 2023

Background

Many sports require maximal strength and endurance performance. Concurrent strength and endurance training can lead to suboptimal training adaptations. However, how adaptations differ between males and females is currently unknown. Additionally, current training status may affect training adaptations.

Objective

We aimed to assess sex-specific differences in adaptations in strength, power, muscle hypertrophy, and maximal oxygen consumption ($$\dot{V}$$

V
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O2max) to concurrent strength and endurance training in healthy adults. Second, we investigated how training adaptations are influenced by strength and endurance training status.

Methods

A systematic review and meta-analysis was conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, and a Cochrane risk of bias was evaluated. ISI Web of science, PubMed/MEDLINE, and SPORTDiscus databases were searched using the following inclusion criteria: healthy adults aged 18–50 years, intervention period of ≥ 4 weeks, and outcome measures were defined as upper- and lower-body strength, power, hypertrophy, and/or $$\dot{V}$$

V
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O2max. A meta-analysis was performed using a random-effects model and reported in standardized mean differences.

Results

In total, 59 studies with 1346 participants were included. Concurrent training showed blunted lower-body strength adaptations in males, but not in females (male: − 0.43, 95% confidence interval [− 0.64 to − 0.22], female: 0.08 [− 0.34 to 0.49], group difference: P = 0.03). No sex differences were observed for changes in upper-body strength (P = 0.67), power (P = 0.37), or $$\dot{V}$$

V
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O2max (P = 0.13). Data on muscle hypertrophy were insufficient to draw any conclusions. For training status, untrained but not trained or highly trained endurance athletes displayed lower $$\dot{V}$$

V
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O2max gains with concurrent training (P = 0.04). For other outcomes, no differences were found between untrained and trained individuals, both for strength and endurance training status.

Conclusions

Concurrent training results in small interference for lower-body strength adaptations in males, but not in females. Untrained, but not trained or highly trained endurance athletes demonstrated impaired improvements in $$\dot{V}$$

V
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O2max following concurrent training. More studies on females and highly strength-trained and endurance-trained athletes are warranted.

Clinical Trial Registration

PROSPERO: CRD42022370894.
Prevalence of anxiety, sleep bruxism and temporomandibular disorders during COVID-19 in Qatari children and adolescents: a cross-sectional study
Authors: Nazzal H. , Baccar M. , Ziad T. , Al-Musfir T. , Al Emadi B. , Matoug-Elwerfelli M. , Narasimhan S. , Khan Y. , Reagu S.
Published: October 2023

Purpose

Understanding the impact of coronavirus disease-2019 (COVID-19) pandemic social restrictions on the lives of children and adolescents is of utmost importance to enable timely diagnosis and treatment. Therefore, the aim of this study was to explore the prevalence of anxiety, sleep bruxism, temporomandibular disorders (TMD) and change in dietary and brushing habits and their association with COVID-19 social restrictions.

Methods

Parents of fit and healthy Qatari children and adolescents were recruited and interviewed by the research team, whereby validated questioners were used to assess the prevalence of children’s/adolescents’ anxiety, sleep bruxism and TMD. Furthermore, changes in dietary and brushing habits were also evaluated.

Results

A total of 199 parents of children and adolescents (mean age = 9.3 ± 3.2 years old) were included. Overall anxiety symptoms, sleep bruxism and TMD were evident in 29.6%, 5.7% and 23.1%, respectively. An increased consumption of food, sweets and worsening of brushing habits were evident in 51.8%, 62.8% and 31.2%, respectively.

Conclusion

Within the limitations of this study, pandemic-related social restrictions could result in elevated levels of anxiety, specifically, social phobia, amongst children and adolescents, which could inevitably lead to unwanted dental consequences.
Discrimination and Dignity Experiences in Prior Oral Care Visits Predict Racialized Oral Health Inequities Among Nationally Representative US Adults
Authors: Raskin Sarah E. , Thakkar-Samtani Madhuli , Santoro Morgan , Fleming Eleanor B. , Heaton Lisa J. , Tranby Eric P.
Published: October 2023

Racism, an oppressive and fallacious sociopolitical hierarchy, is a fundamental cause of oral health inequities worldwide. Everyday discrimination is associated with worse self-rated oral health, toothache and adult tooth loss, and lower oral care utilization. Few studies examine discrimination or microaggressions within oral care settings or their effects on oral health outcomes. We adapted the seven-item Everyday Discrimination Scale to the oral care setting (EDSOC); developed a four-item Dignity in Oral Care Scale (DOCS); fielded them to a probability-based nationally representative sample of US households as part of the 2022 State of Oral Health Equity in America survey (SOHEA, n = 5682); and examined associations between EDSOC and DOCS scores and three outcomes: self-rated oral health, duration since last oral care visit, and planning for future preventive/routine oral care. Nearly, all EDSCOC and DOCS measures were significantly associated with oral health outcomes. Discrimination experience in dental settings had an additive effect on reporting fair/poor oral health and a suppressive effect on planning a future dental visit. Indignity experience doubled-to-quadrupled the likelihood of reporting fair/poor oral health, not having visited a dentist in 2 years, and not planning a future oral care visit. Racio-ethnically minoritized patients may experience the unjust double bind of resolving urgent dental or completing preventive services needs amidst being treated in a discriminatory manner or without dignity. Oral health stakeholders should invest more effort to understand relationships between racism and oral health outcomes and introduce evidence-based interventions to ultimately abolish this societal harm.