bluuebunny/crossref_metadata_2025 huggingface dataset:
Proposing an ensemble machine learning based drought vulnerability index using M5P, dagging, random sub-space and rotation forest models
Authors: Saha Sunil , Kundu Barnali , Paul Gopal Chandra , Pradhan Biswajeet
Published: March 2023

Drought is one of the major barriers to the socio-economic development of a region. To manage and reduce the impact of drought, drought vulnerability modelling is important. The use of an ensemble machine learning technique i.e. M5P, M5P -Dagging, M5P-Random SubSpace (RSS) and M5P-rotation forest (RTF) to assess the drought vulnerability maps (DVMs) for the state of Odisha in India was proposed for the first time. A total of 248 drought-prone villages (samples) and 53 drought vulnerability indicators (DVIs) under exposure (28), sensitivity (15) and adaptive capacity (10) were used to produce the DVMs. Out of the total samples, 70% were used for training the models and 30% were used for validating the models. Finally, the DVMs were authenticated by the area under curve (AUC) of receiver operating characteristics, precision, mean-absolute-error, root-mean-square-error, K-index and Friedman and Wilcoxon rank test. Nearly 37.9% of the research region exhibited a very high to high vulnerability to drought. All the models had the capability to model the drought vulnerability. As per the Friedman and Wilcoxon rank test, significant differences occurred among the output of the ensemble models. The accuracy of the M5P base classifier improved after ensemble with RSS and RTF meta classifiers but reduced with Dagging. According to the validation statistics, M5P-RFT model achieved the highest accuracy in modelling the drought vulnerability with an AUC of 0.901. The prepared model would help planners and decision-makers to formulate strategies for reducing the damage of drought.
Residual motion of cortical versus pedicle screw constructs after decompression, interbody fusion and cross-link augmentation
Authors: Burkhard Marco D. , Cornaz Frédéric , Spirig José Miguel , Wanivenhaus Florian , Fasser Marie-Rosa , Widmer Jonas , Farshad Mazda
Published: March 2023

Purpose

To compare the residual range of motion (ROM) of cortical screw (CS) versus pedicle screw (PS) instrumented lumbar segments and the additional effect of transforaminal interbody fusion (TLIF) and cross-link (CL) augmentation.

Methods

ROM of thirty-five human cadaver lumbar segments in flexion/extension (FE), lateral bending (LB), lateral shear (LS), anterior shear (AS), axial rotation (AR), and axial compression (AC) was recorded. After instrumenting the segments with PS (n = 17) and CS (n = 18), ROM in relation to the uninstrumented segments was evaluated without and with CL augmentation before and after decompression and TLIF.

Results

CS and PS instrumentations both significantly reduced ROM in all loading directions, except AC. In undecompressed segments, a significantly lower relative (and absolute) reduction of motion in LB was found with CS 61% (absolute 3.3°) as compared to PS 71% (4.0°; p = 0.048). FE, AR, AS, LS, and AC values were similar between CS and PS instrumented segments without interbody fusion. After decompression and TLIF insertion, no difference between CS and PS was found in LB and neither in any other loading direction. CL augmentation did not diminish differences in LB between CS and PS in the undecompressed state but led to an additional small AR reduction of 11% (0.15°) in CS and 7% (0.05°) in PS instrumentation.

Conclusion

Similar residual motion is found with CS and PS instrumentation, except of slightly, but significantly inferior reduction of ROM in LB with CS. Differences between CS and PS in diminish with TLIF but not with CL augmentation.
Cranial meningioma with bone involvement: surgical strategies and clinical considerations
Authors: Clynch Abigail L. , Norrington Max , Mustafa Mohammad A. , Richardson George E. , Doherty John A. , Humphries Thomas J. , Gillespie Conor S. , Keshwara Sumirat M. , McMahon Catherine J. , Islim Abdurrahman I. , Jenkinson Michael D. , P. Millward Christopher , Brodbelt Andrew R.
Published: March 2023

Background

Intracranial meningioma with bone involvement and primary intraosseous meningioma is uncommon. There is currently no consensus for optimal management. This study aimed to describe the management strategy and outcomes for a 10-year illustrative cohort, and propose an algorithm to aid clinicians in selecting cranioplasty material in such patients.

Methods

A single-centre, retrospective cohort study (January 2010–August 2021). All adult patients requiring cranial reconstruction due to meningioma with bone involvement or primary intraosseous meningioma were included. Baseline patient and meningioma characteristics, surgical strategy, and surgical morbidity were examined. Descriptive statistics were performed using SPSS v24.0. Data visualisation was performed using R v4.1.0.

Results

Thirty-three patients were identified (mean age 56 years; SD 15) There were 19 females. Twenty-nine patients had secondary bone involvement (88%). Four had primary intraosseous meningioma (12%). Nineteen had gross total resection (GTR; 58%). Thirty had primary ‘on-table’ cranioplasty (91%). Cranioplasty materials included pre-fabricated polymethyl methacrylate (pPMMA) (n = 12; 36%), titanium mesh (n = 10; 30%), hand-moulded polymethyl methacrylate cement (hPMMA) (n = 4; 12%), pre-fabricated titanium plate (n = 4; 12%), hydroxyapatite (n = 2; 6%), and a single case combining titanium mesh with hPMMA cement (n = 1; 3%). Five patients required reoperation for a postoperative complication (15%).

Conclusion

Meningioma with bone involvement and primary intraosseous meningioma often requires cranial reconstruction, but this may not be evident prior to surgical resection. Our experience demonstrates that a wide variety of materials have been used successfully, but that pre-fabricated materials may be associated with fewer postoperative complications. Further research within this population is warranted to identify the most appropriate operative strategy.
Defensive and offensive behaviours in a Kleefstra syndrome mouse model
Authors: Alonso Alejandra , Samanta Anumita , van der Meij Jacqueline , van den Brand Liz , Negwer Moritz , Navarro Lobato Irene , Genzel Lisa
Published: March 2023

Kleefstra syndrome in humans is characterized by a general delay in development, intellectual disability and autistic features. The mouse model of this disease (Ehmt1±) expresses anxiety, autistic-like traits, and aberrant social interactions with non-cagemates. To investigate how Ehmt1± mice behave with unfamiliar conspecifics, we allowed adult, male animals to freely interact for 10 min in a neutral, novel environment within a host-visitor setting. In trials where the Ehmt1± mice were hosts, there were defensive and offensive behaviors. Our key finding was that Ehmt1± mice displayed defensive postures, attacking and biting; in contrast, wild-type (WT) interacting with other WT did not enact such behaviors. Further, if there was a fight between an Ehmt1± and a WT mouse, the Ehmt1± animal was the most aggressive and always initiated these behaviors.
Staphylococcus aureus hitchhiking from colonization to bacteremia via Candida within ICU infection prevention studies: a proof of concept modelling
Authors: Hurley James C.
Published: March 2023

Whether Candida within the patient microbiome drives the pathogenesis of Staphylococcus aureus bacteremia, described as microbial hitchhiking, cannot be directly studied. Group-level observations from studies of various decontamination and non-decontamination-based ICU infection prevention interventions and studies without study interventions (observational groups) collectively enable tests of this interaction within causal models. Candidate models of the propensity for Staphylococcus aureus bacteremia to arise with versus without various antibiotic, anti-septic, and antifungal exposures, each identified as singleton exposures, were tested using generalized structural equation modelling (GSEM) techniques with Candida and Staphylococcus aureus colonization appearing as latent variables within the models. Each model was tested by confrontation against blood and respiratory isolate data, obtained from 467 groups within 284 infection prevention studies. Introducing an interaction term between Candida colonization and Staphylococcus aureus colonization substantially improved GSEM model fit. Model-derived coefficients for singular exposure to anti-septic agents (− 1.28; 95% confidence interval; − 2.05 to − 0.5), amphotericin (− 1.49; − 2.3 to − 0.67), and topical antibiotic prophylaxis (TAP; + 0.93; + 0.15 to + 1.71) as direct effects versus Candida colonization were similar in magnitude but contrary in direction. By contrast, the coefficients for singleton exposure to TAP, as with anti-septic agents, versus Staphylococcus colonization were weaker or non-significant. Topical amphotericin would be predicted to halve both candidemia and Staphylococcus aureus bacteremia incidences versus literature derived benchmarks for absolute differences of < 1 percentage point. Using ICU infection prevention data, GSEM modelling validates the postulated interaction between Candida and Staphylococcus colonization facilitating bacteremia.
Interactions between the individual and the group level in organizations: The case of learning and group turnover
Authors: Blanco-Fernández Darío , Leitner Stephan , Rausch Alexandra
Published: March 2023

Previous research on organizations often focuses on either the individual, team, or organizational level. There is a lack of multidimensional research on emergent phenomena and interactions between the mechanisms at different levels. This paper takes a multifaceted perspective on individual learning and autonomous group formation. To analyze interactions between the two levels, we introduce an agent-based model that captures an organization with a population of heterogeneous agents who learn and are limited in their rationality. To solve a task, agents form a group which experiences turnover from time to time, i.e., its composition changes periodically. We explore organizations that promote learning and changes in group composition either simultaneously or sequentially and analyze the interactions between the activities and the effects on performance. We observe underproportional interactions when tasks are interdependent and show that pushing learning and group turnover too far might backfire and decrease performance significantly.
Introduced rabbits as seed-dispersing frugivores: a study case on a environmentally diverse oceanic island (Tenerife, Canaries)
Authors: Guerrero-Campos María , Mendes Sara Beatriz , Marrero Patricia , Romero Javier , Nieves Concepción , Hervías-Parejo Sandra , González-Mancebo Juana María , Nogales Manuel
Published: March 2023

Rabbits have travelled with humans to the most remote archipelagos, having been introduced on at least 800 islands worldwide. This herbivore has caused a devastating effect on endemic insular plants, causing changes in species composition, cascading extinctions and disruption of native seed dispersal systems worldwide. However, its ecological impacts as disrupting native seed dispersal systems have not been studied from a holistic perspective in any of the archipelagos where rabbits were introduced. Here, we assess the role of rabbits as frugivores and seed-dispersers on the most extensive and diverse island of the Canary Archipelago, Tenerife, across its five main vegetation zones represented in an altitudinal gradient 0–3715 m a.s.l. To this end, 120 transects per vegetation zone were conducted (August 2020–November 2021) to collect fresh faecal samples from a total of 244 latrines. They consisted of 29,538 droppings in which we found seeds from 73 plant species, 29 of which were identified to species level (13 endemic, eight natives and eight introduced by humans). About 70% of the seeds were identified as fleshy-fruited plant species while the remaining nine were dry fruits. Of the former, only nine showed a percentage of intact seeds greater than 75%, another nine species between 50 and 75%, and three lower than 50%. The digestive effect of rabbits on seedling emergence was generally low, compared to that produced by native seed dispersers. Since fleshy-fruited plants and rabbits have not been linked in their evolutionary history in the Canaries, the former seems to have their own legitimate seed dispersers.
How Do Dust Devil-Like Vortices Depend on Model Resolution? A Grid Convergence Study Using Large-Eddy Simulation
Authors: Giersch Sebastian , Raasch Siegfried
Published: March 2023

Dust devils are organized convective vortices with pressure drops of hundreds of pascals that spirally lift surface material into the air. This material modifies the radiation budget by contributing to the atmospheric aerosol concentration. Quantification of this contribution requires good knowledge of the dust devil statistics and dynamics. The latter can also help to understand vortex genesis, evolution and decay, in general. Dust devil-like vortices are numerically investigated mainly by large-eddy simulation (LES). A critical parameter in these simulations is the grid spacing, which has a great influence on the dust devil statistics. So far, it is unknown which grid size is sufficient to capture dust devils accurately. We investigate the convergence of simulated convective vertical vortices that resemble dust devils by using the LES model PALM. We use the nesting capabilities of PALM to explore grid spacings from 10 to 0.625 m. Grid spacings of 1 m or less have never been used for the analysis of dust devil-like vortices that develop in a horizontal domain of more than 10 km$$^2$$2. Our results demonstrate that a minimum resolution of 1.25 m is necessary to achieve a convergence for sample-averaged quantities like the core pressure drop. This grid spacing or smaller should be used for future quantifications of dust devil sediment fluxes. However, sample maxima of the investigated dust devil population and peak velocity values of the general flow show no convergence. If a qualitative description of the dust devil flow pattern is sufficient, we recommend a grid spacing of 2.5 m or smaller.
Pegylated liposomal doxorubicin (Duomeisu®) monotherapy in patients with HER2-negative metastatic breast cancer heavily pretreated with anthracycline and taxanes: a single-arm, phase II study
Authors: Jiang Hanfang , Li Huiping , Song Guohong , Di Lijun , Shao Bin , Yan Ying , Liu Xiaoran , Chen Yifei , Zhang Ruyan , Ran Ran , Liu Yaxin , Gui Xinyu , Wang Nan , Wang Huan
Published: March 2023

Purpose

To evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) in patients with human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) heavily pretreated with anthracycline and taxanes.

Methods

In this single-arm, phase II study, patients with HER2-negative MBC previously treated with anthracycline and taxanes as second- to fifth chemotherapy received PLD (Duomeisu®, generic doxorubicin hydrochloride liposome) 40 mg/m2 every 4 weeks until disease progression, unacceptable toxicity, or completion of six cycles. Primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), objective response rate (ORR), disease control rate (DCR), clinical benefit rate (CBR), and safety.

Results

Of 44 enrolled patients (median age, 53.5 years; range, 34–69), 41 and 36 were evaluable for safety and efficacy, respectively. In total, 59.1% (26/44) of patients had ≥ 3 metastatic sites, 86.4% (38/44) had visceral disease, and 63.6% (28/44) had liver metastases. Median PFS was 3.7 months (95% confidence interval [CI] 3.3–4.1) and median OS was 15.0 months (95% CI 12.1–17.9). ORR, DCR, and CBR were 16.7%, 63.9%, and 36.1%, respectively. The most common adverse events (AEs) were leukopenia (53.7%), fatigue (46.3%), and neutropenia (41.5%), with no grade 4/5 AEs. The most common grade 3 AEs were neutropenia (7.3%) and fatigue (4.9%). Patients experienced palmar-plantar-erythrodysesthesia (24.4%, 2.4% grade 3), stomatitis (19.5%, 7.3% grade 2), and alopecia (7.3%). One patient displayed a left ventricular ejection fraction decline of 11.4% from baseline after five cycles of PLD therapy.

Conclusion

PLD (Duomeisu®) 40 mg/m2 every 4 weeks was effective and well-tolerated in patients with HER2-negative MBC heavily pretreated with anthracycline and taxanes, revealing a potentially viable treatment option for this population.

Trial registration Chinese Clinical Trial Registry: ChiCTR1900022568.
Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists
Authors: Sars Carl , Sackey Helena , Frisell Jan , Dickman Paul W. , Karlsson Fredrik , Kindts Isabelle , Marta Gustavo Nader , Freitas-Junior Ruffo , Tvedskov Tove Filtenborg , Kassem Loay , Ali Ahmed S. , Ihalainen Hanna , Neron Mathias , Kontos Michalis , Kaidar-Person Orit , Meattini Icro , Francken Anne Brecht , van Duijnhoven Frederieke , Moberg Ingvild Ona , Marinko Tanja , Kollar Attila , Ahmed Mahbubl , Remoundos Dennis , Banks Jenny , Jagsi Reshma , Dossett Lesly A. , Lindqvist Ebba K.
Published: March 2023

Purpose

Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. There is little consensus on best practice for the work-up, management, and follow-up of patients with phyllodes tumors of the breast, and evidence-based guidelines are lacking.

Methods

We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors. The survey was constructed in REDCap and distributed between July 2021 and February 2022 through international collaborators in sixteen countries across four continents.

Results

A total of 419 responses were collected and analyzed. The majority of respondents were experienced and worked in a university hospital. Most agreed to recommend a tumor-free excision margin for benign tumors, increasing margins for borderline and malignant tumors. The multidisciplinary team meeting plays a major role in the treatment plan and follow-up. The vast majority did not consider axillary surgery. There were mixed opinions on adjuvant treatment, with a trend towards more liberal regiments in patients with locally advanced tumors. Most respondents preferred a five-year follow-up period for all phyllodes tumor types.

Conclusions

This study shows considerable variation in clinical practice managing phyllodes tumors. This suggests the potential for overtreatment of many patients and the need for education and further research targeting appropriate surgical margins, follow-up time and a multidisciplinary approach. There is a need to develop guidelines that recognize the heterogeneity of phyllodes tumors.
The influence of future weather pattern changes and projected sea-level rise on coastal flood impacts around the UK
Authors: Perks Rachel J. , Bernie Dan , Lowe Jason , Neal Robert
Published: March 2023

When local extreme water levels surpass defences, the consequences can be devastating. We assess the importance of sea-level rise and future weather pattern changes on UK coastal flood impacts. Historical weather pattern classifications are matched with the observed skew surges and significant wave heights. Coastal-risk weather patterns are then defined as ≥ 1% of events in the distribution exceeding the local warning threshold. We combine this methodology with projections of sea-level rise and weather pattern frequency occurrences, to determine the relative importance of each on future coastal risk. A deep low-pressure system situated to the west of Ireland (WP29) has the highest probability (6.3%) of exceeding Newlyn’s present-day warning threshold; this is projected to increase under climate change to 46.2% by 2050 under RCP2.6. This work found that weather patterns associated with storm surges are increasing and decreasing in frequency; a synoptic situation causing windy conditions in the north of the UK (WP23) will increase by > 40% under RCP8.5 by the end of the century (2079–2090). When combining the impact of sea-level rise and changing frequency of weather patterns, this study found that sea-level rise dominates future coastal risk and is highly linked to the future emission scenarios. The need for successful adaptation, such as coastal defence improvements and early warning systems, will become even more important under the higher emission pathway. The most significant increases in coastal risk are found along the east coast, through the English Channel to the north Devon coastline.
Anxiety and Stress Related to COVID-19 Among the Community Dwelling Older Adults Residing in the Largest Refugee Camp of the World
Authors: Anwar Afsana , Yadav Uday Narayan , Huda Md. Nazmul , Das Sukanta , Rosenbaum Simon , Ali A. R. M. Mehrab , Mondal Probal Kumar , Rizwan Abu Ansar Md. , Hossain Syed Far Abid , Das Shuvo Suvasish , Mistry Sabuj Kanti
Published: March 2023

The current cross-sectional study was conducted among 864 older adults aged ≥ 60 years residing in Rohingya refugee camp through face-to-face interviews during November–December 2021. COVID-19-related anxiety was measured using the five-point Coronavirus Anxiety Scale (CAS) and perceived stress using the 10-point Perceived Stress Scale (PSS). The linear regression model identified the factors associated with COVID-19-related anxiety and perceived stress. The prevalence of COVID-19-related anxiety and perceived stress was 68% and 93%, respectively. The average COVID-19-related anxiety score expected to be significantly higher among those who were physically inactive, concerned about COVID-19, had a close friend/family member diagnosed with COVID-19, and had some difficulty in getting food and routine medical care during the COVID-19 pandemic. Meanwhile, the average perceived stress score was expected to be significantly higher among those without partners, who were feeling overwhelmed by COVID-19, and who experienced COVID-19-related anxiety during the pandemic. The findings suggest providing immediate psychosocial support to older Rohingya adults.
Psychological Benefits of Attending Forest School for Preschool Children: a Systematic Review
Authors: Sella Enrico , Bolognesi Monica , Bergamini Emma , Mason Lucia , Pazzaglia Francesca
Published: March 2023

Forest school is a form of outdoor learning that takes children into regular and repeated learning experiences in natural settings. Being based on a comprehensive experience with nature, it is assumed to be beneficial for learning and to promote restorative effects on cognitive and emotional function in preschool children. This review aimed to examine the available evidence on the benefits of forest school compared to indoor school activities in children aged 3 to 6 years. We searched for studies on forest school for preschool children in PsycInfo, JSTOR, and Scopus, with no restriction on publication year. The risk of bias was assessed using Joanna Briggs’s criteria for quasi-experimental design. Of the 190 articles identified, 16 studies were reviewed (N = 1560). Higher benefits were found in children attending forest school compared to those attending indoor school in various areas of child development: cognitive function, motor coordination and balance, connectedness to nature, and health and well-being outcomes. There is, however, still a shortage of empirical evidence, and the methodological quality of most studies was limited. The literature on forest schools for preschool children in general supports positive effects in a wide range of variables that promote child health and development, but more evidence is needed to assess their effectiveness. Due to the methodological weaknesses of the reviewed studies, one should interpret their findings with caution.
An eye-tracking study on how the popularity and gender of the endorsers affected the audience’s attention on the advertisement
Authors: Zahmati Majid , Azimzadeh Seyed Morteza , Sotoodeh Mohammad Saber , Asgari Omid
Published: March 2023

Nowadays, advertising is regarded as one of the vital elements of marketing tools’ promotional strategies. Therefore, advertising is very important to businesses’ marketing strategies and policies. In light of this, the purpose of the current study was to ascertain the influence of endorsers’ gender and the level of attention given to various aspects of advertising. A quasi-experimental study was used for the current investigation. All students at Mashhad’s Ferdowsi University made up the study’s statistical population. 80 students were chosen as the research sample out of the entire student body. Eye motions were captured using an eye tracking gadget. According to research findings, the number and length of fixes on advertisement items were significantly influenced by the popularity of their endorsers. However, there was no statistically significant difference between the genders in terms of the quantity and length of fixations. These conclusions suggest that the popularity of the endorser is a key factor in commercials, but that the endorser’s gender has little effect.
The promise and pitfalls of community-based monitoring with a focus on Canadian examples
Authors: Mamun Abdullah Al , Natcher David C.
Published: March 2023

Community-based monitoring (CBM) is a widely used form of scientific data collection in which local community members directly participate in ecosystem research and also help the process by sharing traditional ecological knowledge and local understanding of land and resources. This paper presents a review of the challenges and opportunities associated with CBM projects in Canada and internationally. While Canadian cases are the primary focus, international examples are drawn on to provide additional context. Based on our review of 121 documents and publications, we found that CBM helps fill science research gaps by providing access to continuous data sets on the ecosystems being studied. CBM also increases the credibility of the data among users, as the community itself takes part in the environmental monitoring process. CBM supports cross-cultural learning and the co-production of knowledge by using traditional ecological knowledge with science, thereby enabling researchers, scientists and community members to learn from one another. Our review suggests that although there are multiple successes, CBM faces several challenges that constrain its progress including funding shortages, lack of support for local stewardship, and inadequate training for local users in the operation of equipment and data collection methods. Data sharing and rights on the use of data are also constraining to the long-term success of CBM programs.
Social Life Cycle Assessment in the Construction Industry: Systematic Literature Review and Identification of Relevant Social Indicators for Carbon Reinforced Concrete
Authors: Backes Jana Gerta , Traverso Marzia
Published: March 2023

This article deals with the application of social life cycle assessment (S-LCA) in the construction sector and explicitly focuses on carbon reinforced concrete (CRC). The publication consists of two parts: (1) a scientific literature review on the current implementation of S-LCA in the construction sector, and (2) the definition of the relevant social hotspots for the cradle-to-gate production of CRC. The literature review was conducted to provide a general overview and compare S-LCA studies in the construction sector; second, countries that provide the relevant input materials needed for CRC were identified. Analysis within the Social Hotspot Database (SHDB) helped determine the relative importance of the CRC supply country for each social category and subcategory. By developing a metric in the form of scores for each risk information, the potential risks indicated by the SHDB were measured. The results show that the focus of the indicators to be highlighted and further used in the indicator catalog is particularly in the area of labor rights and decent work in the health and safety subcategory. Missing data within the SHDB may result in a defined high average score and lead to a lower level of information. In the future, the identified 36 social indicators for CRC should be revised again in cooperation with the manufacturing industry. This study aims to further raise awareness in the construction sector of life-cycle-based sustainability that goes beyond the environmental aspects, and it is the first social hotspot screening using the SHDB for CRC.
Noninvasive electrocardiographic risk factors for sudden cardiac death in dilated ca rdiomyopathy: is ambulatory electrocardiography still relevant?
Authors: Milaras Nikias , Dourvas Panagiotis , Doundoulakis Ioannis , Sotiriou Zoi , Nevras Vasileios , Xintarakou Anastasia , Laina Aggeliki , Soulaidopoulos Stergios , Zachos Panagiotis , Kordalis Athanasios , Arsenos Petros , Archontakis Stefanos , Antoniou Christos-Konstantinos , Tsiachris Dimitrios , Dilaveris Polychronis , Tsioufis Konstantinos , Sideris Skevos , Gatzoulis Konstantinos
Published: March 2023

Risk stratification for sudden cardiac death in dilated cardiomyopathy is a field of constant debate, and the currently proposed criteria have been widely questioned due to their low positive and negative predictive value. In this study, we conducted a systematic review of the literature utilizing the PubMed and Cochrane library platforms, in order to gain insight about dilated cardiomyopathy and its arrhythmic risk stratification utilizing noninvasive risk markers derived mainly from 24 h electrocardiographic monitoring. The obtained articles were reviewed in order to register the various electrocardiographic noninvasive risk factors used, their prevalence, and their prognostic significance in dilated cardiomyopathy. Premature ventricular complexes, nonsustained ventricular tachycardia, late potentials on Signal averaged electrocardiography, T wave alternans, heart rate variability and deceleration capacity of the heart rate, all have both some positive and negative predictive value to identify patients in higher likelihood for ventricular arrhythmias and sudden cardiac death. Corrected QT, QT dispersion, and turbulence slope–turbulence onset of heart rate have yet to establish a predictive correlation in the literature. Although ambulatory electrocardiographic monitoring is frequently used in clinical practice in DCM patients, no single risk marker can be used for the selection of patients at high-risk for malignant ventricular arrhythmic events and sudden cardiac death who could benefit from the implantation of a defibrillator. More studies are needed in order to establish a risk score or a combination of risk factors with the purpose of selecting high-risk patients for ICD implantation in the context of primary prevention.
Zero-heat-flux thermometry over the carotid artery in assessment of core temperature in craniotomy patients
Authors: Silvasti-Lundell Marja , Makkonen Otto , Kivisaari Riku , Luostarinen Teemu , Pesonen Eero , Mäkinen Marja-Tellervo
Published: March 2023

Zero-heat-flux core temperature measurements on the forehead (ZHF-forehead) show acceptable agreement with invasive core temperature measurements but are not always possible in general anesthesia. However, ZHF measurements over the carotid artery (ZHF-neck) have been shown reliable in cardiac surgery. We investigated these in non-cardiac surgery. In 99 craniotomy patients, we assessed agreement of ZHF-forehead and ZHF-neck (3M™ Bair Hugger™) with esophageal temperatures. We applied Bland-Altman analysis and calculated mean absolute differences (difference index) and proportion of differences within ± 0.5 °C (percentage index) during entire anesthesia and before and after esophageal temperature nadir. In Bland-Altman analysis [mean (limits of agreement)], agreement with esophageal temperature during entire anesthesia was 0.1 (−0.7 to +0.8) °C (ZHF-neck) and 0.0 (−0.8 to +0.8) °C (ZHF-forehead), and, after core temperature nadir, 0.1 (−0.5 to +0.7) °C and 0.1 (−0.6 to +0.8) °C, respectively. In difference index [median (interquartile range)], ZHF-neck and ZHF-forehead performed equally during entire anesthesia [ZHF-neck: 0.2 (0.1–0.3) °C vs ZHF-forehead: 0.2 (0.2–0.4) °C], and after core temperature nadir [0.2 (0.1–0.3) °C vs 0.2 (0.1–0.3) °C, respectively; all p > 0.017 after Bonferroni correction]. In percentage index [median (interquartile range)], both ZHF-neck [100 (92–100) %] and ZHF-forehead [100 (92–100) %] scored almost 100% after esophageal nadir. ZHF-neck measures core temperature as reliably as ZHF-forehead in non-cardiac surgery. ZHF-neck is an alternative to ZHF-forehead if the latter cannot be applied.
Identification of the NA+/K+-ATPase α-Isoforms in Six Species of Poison Dart Frogs and their Sensitivity to Cardiotonic Steroids
Authors: Medina-Ortiz Katherine , Navia Felipe , Mosquera-Gil Claudia , Sánchez Adalberto , Sterling Gonzalo , Fierro Leonardo , Castaño Santiago
Published: March 2023

Cardiotonic steroids (CTS) are a group of compounds known to be toxic due to their ability to inhibit the Na+/K+-ATPase (NKA), which is essential to maintain the balance of ions in animal cells. An evolutionary strategy of molecular adaptation to avoid self-intoxication acquired by CTS defended organisms and their predators is the structural modification of their NKA where specific amino acid substitutions confer resistant phenotypes. Several lineages of poison dart frogs (Dendrobatidae) are well known to sequester a wide variety of lipophilic alkaloids from their arthropod diet, however there is no evidence of CTS-sequestration or dietary exposure. Interestingly this study identified the presence of α-NKA isoforms (α1 and α2) with amino acid substitutions indicative of CTS-resistant phenotypes in skeletal muscle transcriptomes obtained from six species of dendrobatids: Phyllobates aurotaenia, Oophaga anchicayensis, Epipedobates boulengeri, Andinobates bombetes, Andinobates minutus, and Leucostethus brachistriatus, collected in the Valle del Cauca (Colombia). P. aurotaenia, A. minutus, and E. boulengeri presented two variants for α1-NKA, with one of them having these substitutions. In contrast, O. anchicayensis and A. bombetes have only one α1-NKA isoform with an amino acid sequence indicative of CTS susceptibility and an α2-NKA with one substitution that could confer a reduced affinity for CTS. The α1 and α2 isoforms of L. brachistriatus do not contain substitutions imparting CTS resistance. Our findings indicate that poison dart frogs express α-NKA isoforms with different affinities for CTS and the pattern of this expression might be influenced by factors related to evolutionary, physiological, ecological, and geographical burdens.
Approximating biobjective minimization problems using general ordering cones
Authors: Herzel Arne , Helfrich Stephan , Ruzika Stefan , Thielen Clemens
Published: March 2023

This article investigates the approximation quality achievable for biobjective minimization problems with respect to the Pareto cone by solutions that are (approximately) optimal with respect to larger ordering cones. When simultaneously considering $$\alpha $$
α
-approximations for all closed convex ordering cones of a fixed inner angle $$\gamma \in \left[ \frac{\pi }{2}, \pi \right] $$

γ
∈

π
2

,
π

, an approximation guarantee between $$\alpha $$
α
and $$2 \alpha $$

2
α

is achieved, which depends continuously on $$\gamma $$
γ
. The analysis is best-possible for any inner angle and it generalizes and unifies the known results that the set of supported solutions is a 2-approximation and that the efficient set itself is a 1-approximation. Moreover, it is shown that, for maximization problems, no approximation guarantee is achievable in general by considering larger ordering cones in the described fashion, which again generalizes a known result about the set of supported solutions.
Numerical modeling of a potential landslide-generated tsunami in the southern Strait of Georgia
Authors: Nemati Fatemeh , Leonard Lucinda , Thomson Richard , Lintern Gwyn , Kouhi Soroush
Published: March 2023

We report results of numerical simulations of a potential subaerial landslide on the coast of Orcas Island and the resultant tsunami waves in the southern Strait of Georgia near the US/Canada border. A likely trigger is strong ground shaking during large earthquakes on the nearby Holocene active Skipjack Island fault zone. For a worst-case scenario, we assume a 0.17 $${\textrm{km}}^3$$

km

3

rigid subaerial failure on the steep northeast coast of the island, spanning the $$\sim$$
∼
 5 km between previous landslide deposits on the adjacent seafloor. The landslide motion and resulting tsunami generation are modeled using the three-dimensional (3D) non-hydrostatics physics-based NHWAVE model. The simulated failure moves downslope with a peak velocity of 13.64ṁ/s and travels 732 m before coming to rest after 85 s in 75-m water depth. Tsunami propagation is then continued using the 2D fully nonlinear and dispersive Boussinesq wave model FUNWAVE-TVD in a succession of layered and nested grids. The modeling reveals susceptible locations, particularly as waves will arrive with little or no warning. In the near-source region, modeled waves have peak amplitudes of 15–20 m, current speeds of up to 10 m/s, and runup of up to 30 m. Smaller, but significant, wave amplitudes and runup occur throughout the region surrounding Orcas Island. In the tsunami propagation direction, runup reaches 7.5 m at Neptune Beach near Lummi Bay. Both initial and reflected waves cause significant runup (> 1.5 m) along much of the shoreline between Point Roberts and Lummi Bay.
How to write a successful grant application: guidance provided by the European Society of Clinical Pharmacy
Authors: Weidmann Anita E. , Cadogan Cathal A. , Fialová Daniela , Hazen Ankie , Henman Martin , Lutters Monika , Okuyan Betul , Paudyal Vibhu , Wirth Francesca
Published: March 2023

Considering a rejection rate of 80–90%, the preparation of a research grant is often considered a daunting task since it is resource intensive and there is no guarantee of success, even for seasoned researchers. This commentary provides a summary of the key points a researcher needs to consider when writing a research grant proposal, outlining: (1) how to conceptualise the research idea; (2) how to find the right funding call; (3) the importance of planning; (4) how to write; (5) what to write, and (6) key questions for reflection during preparation. It attempts to explain the difficulties associated with finding calls in clinical pharmacy and advanced pharmacy practice, and how to overcome them. The commentary aims to assist all pharmacy practice and health services research colleagues new to the grant application process, as well as experienced researchers striving to improve their grant review scores. The guidance in this paper is part of ESCP’s commitment to stimulate “innovative and high-quality research in all areas of clinical pharmacy”.
Two conceptions of absolute generality
Authors: Florio Salvatore , Jones Nicholas K.
Published: March 2023

What is absolutely unrestricted quantification? We distinguish two theoretical roles and identify two conceptions of absolute generality: maximally strong generality and maximally inclusive generality. We also distinguish two corresponding kinds of absolute domain. A maximally strong domain contains every potential counterexample to a generalisation. A maximally inclusive domain is such that no domain extends it. We argue that both conceptions of absolute generality are legitimate and investigate the relations between them. Although these conceptions coincide in standard settings, we show how they diverge under more complex assumptions about the structure of meaningful predication, such as cumulative type theory. We conclude by arguing that maximally strong generality is the more theoretically valuable conception.
Birds of a Feather Get Angrier Together: Social Media News Use and Social Media Political Homophily as Antecedents of Political Anger
Authors: Cheng Zicheng , Marcos-Marne Hugo , Gil de Zúñiga Homero
Published: March 2023

A significant body of literature within political communication revolves around the constructive political virtues and blighting social and democratic consequences of political anger. For the most part, studies have focused on identifying the primary causes and antecedents of political anger. However, within the context of social media, fewer efforts have been devoted to clarifying how and what infuriates people about politics. Does social media news use relate to increased or reduced levels of political anger? Do social media political homophilic networks explain political anger? And to what extent does political homophily influence the potential effect of social media news use on citizens’ political anger levels—moderating effect? Results drawing on a two-wave U.S. survey dataset show that the frequency of social media news use alone has no direct effect on people’s increased political anger, whereas interacting in homophilic discussion and information networks on social media positively associates with anger. Furthermore, the relationship between social media news use and political anger is contingent upon social media political homophily. Those who report high levels of social media news use and very low levels of social media political homophily end up being less angry over time. Limitations and steps for future research are discussed in the manuscript.
Female Sexual Dysfunction in Subjects with Type 2 Diabetes Mellitus
Authors: Derosa Giuseppe , Romano Davide , D’Angelo Angela , Maffioli Pamela
Published: March 2023

The correlation of female sexual dysfunction (FSD) with the degree of glycemic control, the duration and complications of diabetic disease and cardiovascular risk factors are not so clear. The aim of this study was to assess the prevalence of FSD in a sample of females with type 2 diabetes mellitus (T2DM), and to identify factors involved in its pathogenesis. We enrolled 81 females who have T2DM. We administered the female sexual function index (FSFI), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) questionnaires. We also estimated anthropometric parameters, glyco-metabolic control, comorbidities, autonomic nervous system assessment, some adipocytokines and ongoing therapy. 87% of participants were affected by FSD. There was evidence of an inverse correlation between the total score of the FSFI questionnaire and the mean of the values ​​of HbA1c in the previous years. There was an inverse correlation with the duration of diabetes and homeostasis model assessment of insulin resistance index in participants not affected by FSD. Participants with FSD have a higher prevalence of anxiety (p = 0.043) and participants with depression and ischemic heart disease scored less on the FSFI questionnaire (p = 0.005 and p = 0.010, respectively). Homocysteine ​​and E-selectin values ​were higher in participants with FSFI (p = 0.002, and p = 0.017, respectively). Most of the enrolled females with T2DM had FSD. Glycemic control, ischemic heart disease, endothelial dysfunction, autonomic neuropathy, and psychological conditions, such as anxiety and depression, seem to have a close correlation with FSD. An early diagnosis of FSD can help to improve not only participants’ quality of life, but also to early identify and treat risk factors related not only to FSD, but also to cardiovascular risk. Therefore, we highly recommend that clinicians have a high index of suspicion for FSD in females with T2DM.
Building an open-source system test generation tool: lessons learned and empirical analyses with EvoMaster
Authors: Arcuri Andrea , Zhang Man , Belhadi Asma , Marculescu Bogdan , Golmohammadi Amid , Galeotti Juan Pablo , Seran Susruthan
Published: March 2023

Research in software testing often involves the development of software prototypes. Like any piece of software, there are challenges in the development, use and verification of such tools. However, some challenges are rather specific to this problem domain. For example, often these tools are developed by PhD students straight out of bachelor/master degrees, possibly lacking any industrial experience in software development. Prototype tools are used to carry out empirical studies, possibly studying different parameters of novel designed algorithms. Software scaffolding is needed to run large sets of experiments efficiently. Furthermore, when using AI-based techniques like evolutionary algorithms, care needs to be taken to deal with their randomness, which further complicates their verification. The aforementioned represent some of the challenges we have identified for this domain. In this paper, we report on our experience in building the open-source EvoMaster tool, which aims at system-level test case generation for enterprise applications. Many of the challenges we faced would be common to any researcher needing to build software testing tool prototypes. Therefore, one goal is that our shared experience here will boost the research community, by providing concrete solutions to many development challenges in the building of such kind of research prototypes. Ultimately, this will lead to increase the impact of scientific research on industrial practice.
Effect of sodium–glucose transporter 2 inhibitor empagliflozin on proteinuria and kidney function progression in patients with non-diabetic glomerulonephritis: a pilot superiority randomized controlled trial
Authors: Hammad Hany , Shaaban Asmaa , Philips Mariana Victor , Fayed Ahmed , Abdelaziz Tarek Samy
Published: March 2023

Background

Amelioration of proteinuria is one of main treatment targets in patients with glomerulonephritis, yet the remission rates are suboptimal.

Aim of the study

To examine the effect of the sodium–glucose transporter 2 inhibitor (empagliflozin) on proteinuria and kidney function progression, in patients with glomerulonephritis not due to diabetic kidney diseases.

Subjects and methods

Fifty patients were recruited. The entry criteria were diagnosis of glomerulonephritis, and proteinuria (proteinuria ≥ 500 mg⁄g) in spite of the use of the maximal tolerated dose of RAAS blocking agents together with specific immunosuppression treatment regimens. Group 1 (Empagliflozin arm): 25 patients who received 25 mg of empagliflozin once daily for 3 months as add-on to their regular treatment protocol (RAAS blockers and immunosuppression). Group 2 (Placebo arm): 25 patients treated with RAAS blockers and immunosuppression. The primary efficacy endpoints were the change in creatinine eGFR, and proteinuria 3 months after starting treatment.

Results

Progression of proteinuria was lower with empagliflozin as compared to placebo (odds ratio, 0.65; 95% CI, 0.55 to 0.72, p = 0.002). Decline in eGFR was lower with empagliflozin as compared to placebo; however, this was statistically not significant (odds ratio, 0.84; 95% CI, 0.82 to 1.2, p = .31). The percentage change in proteinuria was greater with empagliflozin as compared to placebo (median, − 77 (− 97–105) vs − 48 (− 80–117).

Conclusion

Empagliflozin has a favorable effect on amelioration of proteinuria in patients with glomerulonephritis. Empagliflozin has tendency to preserve kidney function in patients with glomerulonephritis as compared to placebo; however, longer term studies are required.