bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of COVID-19 Numbers by Using Fisher Transform Indicator
Authors: Ferhat
Published: February 2023

New cases, new deaths, new deaths per new cases numbers belonging to COVID-19 pandemic investigated via open, high, low, close candlesticks and Fisher transform indicator. Candlestick plots, accompanied by crossovers in the Fisher transform indicator, facilitate the determination of the beginning of upward and downward trends in numbers, clearly and in a timely manner. It has been shown that an increase in the total number of peaks over time, in both smoothed candlestick data and in the Fisher transform indicator, can indicate the temporary or persistent diminishing of a pandemic.
­Field-induced concentration and low coordination-enhanced adsorption boost electroreductive deuteration of nitriles over copper nanotips
Authors: He Meng , Li Rui , Cheng Chuanqi , Yang Lijun , Wu Yongmeng , Liu Cuibo , Zhang Bin
Published: February 2023

Electrochemical deuteration utilizing D2O is a promising room-temperature strategy for synthesizing deuterated molecules. At present, high Faradic efficiencies (FEs) at high reaction rates are extraordinarily significant but highly challenged. Here, high-curvature low-coordinated copper nanotips (LC-Cu NTs) are designed to enable electroreductive deuteration of α-deuterio aryl acetonitriles, in situ generated from fast α-H/D exchange of acetonitriles in D2O, to α,β-deuterio arylethyl primary amines with 90% FE and 0.11 mmol h-1 cm-2, greatly outperforming the reported data and other Cu counterparts. The increased electric fields of the nanotips concentrate nitriles and K+(D2O)n, and low-coordination sites promote nitriles and D2O adsorption, thus facilitating nitrile deuteration with an excellent reaction rate. The higher coupling energy barrier of active hydrogen atoms at low-coordination sites restricts the D2 evolution, accounting for the outstanding FE. The wide substrate scope, easy gram-scale synthesis, and facile preparation of d4-melatonin with enhanced antitumor and antioxidation effects highlight its great promise. Furthermore, the application of LC-Cu NTs in other deuteration reactions with improved reaction rates and FEs rationalizes the design concept.
Regarding the Gap between Prime Numbers
Authors: Thompson Daniel
Published: February 2023

Until now there is no efficient formula for determining the prime numbers. I show an efficient formula that takes only prime number values or multiples of 5, 7 and 11, and results in the successive prime number or a multiple of 5, 7 and 11. It is shown that by performing the same operation on a number that is a multiple of a prime number when using the formula will result in the next successive prime number value. The formula also identifies a pattern allowing mathematicians to begin at any random prime number and find the next successive prime number without fail.
MSC:11-xx
FEATURES OF PERSONNEL MANAGEMENT MEDICAL INSTITUTION
Authors: Samoday Valentyna , Rybalchenko Svitlana , Slatvytska N.
Published: February 2023

The article is dedicated to the development of the features of the molding and the development of the personnel management system to the pledge of health protection. The staff of the medical mortgage is the succession of practitioners, to ensure the efficiency and competitiveness of the medical mortgage, the meta-activity of any kind of support for superior medical services and highly qualified medical assistance. Revealed negative trends in the system of personnel security of the health care department. The article characterizes the personnel management system of the medical and sanitary unit of PJSC "SUMIKHIMPROM". The main elements of the personnel management system are: planning, improvement, continuous improvement, remuneration of opportunities to distribute personnel on the basis of motivation to staff and regular monitoring and objective assessment of yoga practice. The authors carried out an examination of the personnel of the medical and sanitary unit of the PJSC "SUMIKHIMPROM" with the method of revealing the main motives for the professional activity of medical personnel. For the results of the experience in the first place, the staff set wages, medical services and satisfaction with the work done. On the other side, there is a friendliness of colleagues, a friendly social and psychological climate in the team. No less important for the staff is the possibility of self-realization, the social package and recognition. The experiment showed that close to 50% of the staff are not satisfied with the motivation system. On the basis of the analysis carried out by the authors, the weak side of the functioning of the personnel management system of the medical l and sanitary unit PJSC "SUMIKHIMPROM" was revealed, and itself: the personnel policy is weak, the system of motivation for medical personnel is ineffective. The proposed systematic approach to improving the personnel management of medical and sanitary unit PJSC "SUMIKHIMPROM". A thorough system of personnel management can be taken into account by the improvement of the vectors of reforms that are being implemented in health care, which could help medical personnel, and the need for personnel. It is also an additional promotion of changes in the system of motivation of medical personnel. The development of a system of motivation for medical personnel can be carried out not only on the equal basis of the pledge of health protection, but also on the regional and sovereign level
High-pressure behavior and structural transition of beryl-type johnkoivulaite, Cs(Be2B)Mg2Si6O18
Authors: Gatta G. Diego , Ende Martin , Miloš Sofija , Rotiroti Nicola , Palke Aaron C. , Miletich Ronald
Published: February 2023

The beryl-group mineral johnkoivulaite, Cs(Be2B)Mg2Si6O18, was compressed hydrostatically in a diamond-anvil cell up to 10.2 GPa. In situ Raman spectroscopy and X-ray crystallography revealed a P6/mcc-to-P3c1 (second-order) phase transition on isothermal compression at the critical transition pressure Pc = 4.13 ± 0.07 GPa. The elastic parameters determined for the volume elasticity of the two polymorphs correspond to a Birch-Murnaghan equation of state with K0 = 148 ± 2 GPa and K′ = 0 for P < Pc and K0 = 75.5 ± 0.9 GPa with K′ = 4 for P > Pc. The low-P polymorph shows anomalously linear compression behavior, as reported for several other beryl-derived framework structures. The high-P polymorph, which was found to follow a a′ = a·√3, c′ = c superstructure according to P3c1, is almost twice as compressible as its low-P form. This is unique for any beryl-derived structure and can be attributed to the high degree of freedom for atomic displacements in the superstructure. The reduced symmetry can also be understood as the effect of the driving mechanism of the transformation. The extra-framework Cs channel components counteract any lateral deformation of the channels parallel to [0001] within the microporous framework and, similar to pezzottaite, are responsible for maintaining the trigonal/hexagonal lattice metrics.
The impact of water resource taxes on total factor water efficiency
Authors: Su Yang , Cheng Zhonghua
Published: February 2023

Widespread promotion of resource tax reform is of critical importance in China's efforts to promote resource conservation and speed up the development of a more ecological planet. Using the Differences-in-Differences (DID) approach, this article empirically assesses the impact of water resource tax reform on total factor water efficiency and its mechanism of action in order to examine the effect of China's water resource tax reform policy from 2010 to 2019. According to the study, water resource tax reform enhances total factor water efficiency substantially. Following a battery of robustness tests, this conclusion remains valid. Further examination of the policy's mechanism finds that it encourages increases in total factor water efficiency through increasing marketization, enhancing innovation capabilities, supporting industrial structure upgrades, and strengthening the intensity of environmental regulations. The research in this article provides a basis for decision-making and so further promotes the pilot policy of water resource tax reform across the country.
Evaluation of regional water cycle health based on EFAST-cloud model: A case study of Henan Province, China
Authors: Liu Peiheng , Han Yuping , Lü Subing , Wang Fuqiang
Published: February 2023

The regional water cycle is increasingly reflecting the dual role of natural and social processes, and is affected by global climate change and strong human intervention. The study of water cycle health evaluation has provided guidance to urban planning, development, and resource management. In this study, a water cycle health evaluation method based on EFAST-Cloud model is proposed, and Henan Province of China is selected as a typical study area. The water cycle health status is evaluated from four dimensions of water ecology, water quality, water abundance, and water utilization. The evaluation results are compared with those of fuzzy comprehensive evaluation as well. It is shown that the established EFAST-Cloud model results of assessment are consistent with the Fuzzy comprehensive evaluation method, while it has the advantage of being able to evaluate the proportion of each grade in detail by reflecting the randomness and fuzziness of the evaluation. According to the statistical data from 2007 to 2018, the whole area is in a sub-healthy state. During the 12-year period, the health status of the water cycle has been improved year by year. The research results can provide theoretical basis for repairing regional water environment and promoting regional sustainability.
Slow filtration operating conditions for the removal of opportunistic pathogens in a secondary effluent
Authors: Sun Lihua , Zhang Muxi , Zhu Junyao , Xi Zixuan , Feng Cuimin
Published: February 2023

The secondary effluent of urban sewage treatment plants contains many opportunistic pathogens (OPs), which pose a potential threat to human health. In this study, the slow filtration technique is employed as the advanced treatment procedure, with the secondary effluent as the treatment object. The effectiveness of the operating conditions of the slow filtration process (filtration rate and Ca2+ concentration) in removing OPs (Pseudomonas aeruginosa, Legionella and Mycobacterium avium) and Escherichia coli from water, as well as the dynamic deposition process of pollutants on the surface of the slow filtration biofilm, was investigated. The results showed that under different filtration rates and different Ca2+ concentrations, biofilm slow filtration was more effective in removing OPs than slow filtration. The optimal filtration rate of biofilm slow filtration was 5 cm/h, and the optimal inlet Ca2+ concentration was 60 mg/L. When the filtration rate was 5 cm/h, the deposition of pollutants in the secondary effluent on the surface of biofilm slow filtration was mainly dominated by the physical adhesion of extracellular polymeric substances (EPS). When the concentration of Ca2+ was 60 mg/L, the adsorption of microorganisms was the primary method.
Strategies for Treatment of Thyroid Cancer
Authors: Yadav Deepika , Mishra Prem Shankar , Sharma Pramod Kumar , Malviya Rishabha
Published: February 2023

More people are diagnosed with thyroid cancer than any other endocrine tumor. Differentiated
thyroid cancer is often treated by removing the thyroid gland (thyroidectomy), iodizing radiation,
or inhibiting thyroid stimulating hormone (TSH). Advanced thyroid carcinomas are notoriously
resistant to chemotherapy, thus the pursuit of alternative treatments is vital. The best methods
for treating individuals with advanced nonmedullary and medullary thyroid carcinomas are discussed
in this post. Numerous tyrosine kinase inhibitors and antiangiogenic inhibitors, two types of
novel target therapy, have shown promise in studies for individuals with thyroid cancer. Both the
positive and unfavourable outcomes of clinical studies of these drugs were addressed. The findings
presented here are encouraging, but more study is required to establish whether or not this method
is effective in the treatment of thyroid cancer.
Andrographis paniculata and Andrographolide - A Snapshot on Recent
Advances in Nano Drug Delivery Systems against Cancer
Authors: Deshmukh Rohitas , Jain Aman Kumar , Singh Rajesh , Paul Swarnali Das , Harwansh Ranjit K.
Published: February 2023

Cancer is one of the deadliest illnesses of the 21st century. Chemotherapy and radiation therapies
both have considerable side effects. Antitumor antibiotics are one of them. Coughs, common colds,
fevers, laryngitis, and infectious disorders have all been treated with Andrographis paniculata for centuries.
Extracts of Andrographis effectively treat various ailments, as well as cancer. The most active
molecule in Andrographis paniculata is andrographolide a, diterpene, and lactone. Andrographis paniculata
and its derivatives have long been used to treat various ailments. Anti-inflammatory and cancerfighting
characteristics have been observed in Andrographolide. Andrographolide, a diterpene lactone
separated from Andrographis paniculata, has also been shown to have important criticalessential biological
protective properties. It has also been suggested that it could be used to treat major human diseases
like-rheumatoid like rheumatoid, colitis, and Parkinsons disease. This summary aims to highlight
Andrographolide as a promising cancer treatment option. Several databases were searched for andrographolides
cytotoxic/anti-cancer effects in pre-clinical and clinical research to serve this purpose. Several
studies have shown that Andrographolide is helpful in cancer medication, as detailed in this review.
Acridine: A Scaffold for the Development of Drugs for Alzheimer's Disease
Authors: Sharma Anuradha , Piplani Poonam
Published: February 2023

Alzheimer's disease (AD) is drawing scientists' consideration, being one of the gravest diseases mankind will have to battle against in the near future. The number of people with AD is expected to triple in the next 40 years. It is a most common age-related multifactorial neurodegen-erative disease and characterized by two histopathological hallmarks; the formation of senile plaques composed of the amyloid-β (Aβ) peptide and neurofibrillary tangles composed of hyper-phosphorylated tau protein. Discovery and development of rationally designed multi-targeted lig-ands for the management of AD could be more beneficial than classical single targeted molecules. Acridine, a heterocyclic nucleus is a sole moiety in various existing drug molecules such as quina-crine (antimalarial), acriflavine and proflavine (antiseptics), ethacridine (abortifacient), amsacrine and nitracine (anticancer) and tacrine (anti-Alzheimer). It is proposed that acridine may combat the AD by acting on several targets like acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), dual specificity tyrosine kinase 1A (Dyrk 1A), amyloid and prion protein (PrPC) etc. involved in its pathogenesis. The main aim of this compilation is to review the most promising therapeutic devel-opments within the vast research area dealing with acridine derivatives. Further research is required to evaluate the effectiveness of the acridine derivatives with various substitutions in the treatment of AD. In conclusion, our review will suggest the potentiality of the versatile acridine framework for drug designing and developing novel multi-target inhibitors for the Alzheimer’s disease.
Investigating Biomarkers for COVID-19 Morbidity and Mortality
Authors: Fiore Marco , Ceci Flavio Maria , Ferraguti Giampiero , Lucarelli Marco , Angeloni Antonio , Bonci Enea , Petrella Carla , Francati Silvia , Barbato Christian , Di Certo Maria Grazia , Gabanella Francesca , Gavaruzzi Francesca , Mastroianni Claudio Maria , Minni Antonio , Greco Antonio , Ralli Massimo , Ceccanti Mauro , Tarani Luigi
Published: February 2023

Background and Objective:

This retrospective study aims to disclose further early pa-rameters of COVID-19 morbidity and mortality.

Methods:

Three hundred and eighty-two COVID-19 patients, recruited between March and April 2020, were divided into three groups according to their outcome: (1) hospital ward group (patients who entered the hospital wards and survived); (2) intensive care unit (ICU) group (patients who at-tended the ICU and survived); (3) the deceased group (patients admitted to ICU with a fatal out-come). We investigated routine laboratory parameters such as albumin, glycemia, hemoglobin am-ylase, lipase, AST, ALT, GGT, LDH, CK, MGB, TnT-hs, IL-6, ferritin, CRP, PCT, WBC, RBC, PLT, PT, INR, APTT, FBG, and D-dimer. Blood withdrawal was carried out at the beginning of the hospitalization period.

Results:

ANOVA and ROC data evidenced that the concomitant presence of alterations in albumin, lipase, AST, ALT, LDH, MGB, CK, IL-6, ferritin in women, CRP and D-dimer is an early sign of fatal outcomes.

Conclusion:

The present study confirms and extends the validity of routine laboratory biomarkers (i.e., lipase, AST, ALT, LDH, CK, IL-6, ferritin in women, CRP and D-dimer) as indicators of COVID-19 morbidity and mortality. Furthermore, the investigation suggests that both gross changes in albumin and MGB, markers of liver and heart damage, may early disclose COVID-19 fatal out-comes.
New Perspectives of Taxifolin in Neurodegenerative Diseases
Authors: Yang Rong , Yang Xinxing , Zhang Feng
Published: February 2023

Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD),
cerebral amyloid angiopathy (CAA), and Huntington’s disease (HD) are characterized by cognitive
and motor dysfunctions and neurodegeneration. These diseases have become more severe over time
and cannot be cured currently. Until now, most treatments for these diseases are only used to relieve
the symptoms. Taxifolin (TAX), 3,5,7,3,4-pentahydroxy flavanone, also named dihydroquercetin, is a
compound derived primarily from Douglas fir and Larix gemelini. TAX has been confirmed to exhibit
various pharmacological activities, including anti-inflammation, anti-cancer, anti-virus, and regulation
of oxidative stress effects. In the central nervous system, TAX has been demonstrated to inhibit Aβ fibril
formation, protect neurons and improve cerebral blood flow, cognitive ability, and dyskinesia. At
present, TAX is only applied as a health additive in clinical practice. This review aimed to summarize
the application of TAX in neurodegenerative diseases and the underlying neuroprotective mechanisms,
such as suppressing inflammation, attenuating oxidative stress, preventing Aβ protein formation,
maintaining dopamine levels, and thus reducing neuronal loss.
Alcoholic/Nonalcoholic Fatty Liver Disease Detection with Transient
Elastography: A Detailed Review and Meta-analysis
Authors: Fang Yinyou , Li Xiaofei , Zong Fang , Jiang Tianan
Published: February 2023

Background:

The liver plays a significant role in the digestive system, and disease in the liver initiates various other problems. The liver is severely affected due
to alcohol use, and it initiates various chronic diseases, including Alcohol-Related Liver Disease (ARLD). Alcoholic/Nonalcoholic Fatty Liver
Disease (AFLD/NFLD) is a severe medical emergency, and early screening and treatment are necessary to cure the patient. The untreated
AFLD/NFLD will cause various problems, including fatigue, weight loss, and discomfort in the abdomen.

Objective:

This study aims to present a detailed review and investigation of schemes considered in medical clinics to identify the AFLD/NFLD coupled
problems and present the merit of the Transient Elastography (TE) combined with Fibroscan® practice to identify liver abnormality.

Methods:

This research aims to study the clinical significance and the accuracy of TE-supported liver illness screening.

Results:

This work aims to collect the recent research works and clinical reports published from 2011 to 2021 from the chosen databases and provide a
detailed review using the clinical information discussed in the selected articles.

Conclusion:

The essential statistical investigation of the collected data is executed with Review Manager (RevMan®) software, and the significance of the TE is
confirmed using the articles supporting a 2x2 contingency table, and each case is evaluated using a p-score and the Region of Convergence (RoC)
curve for 95% confidence intervals.
Exploring the Mechanism of Buyang Huanwu Decoction Alleviating Restenosis by Regulating VSMC Phenotype Switching and Proliferation by Network Pharmacology and Molecular Docking
Authors: Chen Xueqin , Yu Jingyue , Lei Huan , Li Lei , Liu Xupin , Liu Bo , Xie Yanfei , Fang Haihong
Published: February 2023

Background:

Buyang Huanwu Decoction (BHD) is used to regulate blood circulation and clear collaterals and is widely used in coronary heart disease. However, the active compounds and the mechanism of BHD used to treat restenosis are less understood.

Objective:

The study aimed to explore the potential mechanism of Buyang Huanwu decoction BHD for the treatment of restenosis using network pharmacology and molecular docking experiments.

Methods:

The bioactive components of BHD and their corresponding targets were retrieved from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) and Encyclopaedia of Traditional Chinese Medicine (ETCM) databases as well as literature. Restenosisassociated therapeutic genes were identified from the OMIM, Drugbank, GEO, and Dis- GeNET databases. Genes related to the vascular smooth muscle cell (VSMC) phenotype were obtained from the gene ontology (GO) database and literature. The core target genes for the drug-disease-VSMC phenotype were identified using the Venn tool and Cytoscape software. Moreover, the “drug-component-target-pathway” network was constructed and analyzed, and pathway enrichment analysis was performed. The connection between the main active components and core targets was analyzed using the AutoDock tool, and PyMOL was used to visualize the results.

Result:

The “compound-target-disease” network included 80 active ingredients and 599 overlapping targets. Among the bioactive components, quercetin, ligustrazine, ligustilide, hydroxysafflor yellow A, and dihydrocapsaicin had high degree values, and the core targets included TP53, MYC, APP, UBC, JUN, EP300, TGFB1, UBB, SP1, MAPK1, SMAD2, CTNNB1, FOXO3, PIN1, EGR1, TCF4, FOS, SMAD3, and CREBBP. A total of 365 items were obtained from the GO functional enrichment analysis (p < 0.05), whereas the enrichment analysis of the KEGG pathway identified 30 signaling pathways (p < 0.05), which involved the TGF-β signaling pathway, Wnt signaling pathway, TRAF6-mediated induction of NF-κB and MAPK pathway, TLR7/8 cascade, and others. The molecular docking results revealed quercetin, luteolin, and ligustilide to have good affinity with the core targets MYC and TP53.

Conclusion:

The active ingredients in BHD might act on TP53, MYC, APP, UBC, JUN, and other targets through its active components (such as quercetin, ligustrazine, ligustilide, hydroxysafflor yellow A, and dihydrocapsaicin). This action of BHD may be transmitted via the involvement of multiple signaling pathways, including the TGF-β signaling pathway, Wnt signaling pathway, TRAF6-mediated induction of NF-κB and MAPK pathway, and TLR7/8 cascade, to treat restenosis by inhibiting the phenotype switching and proliferation of VSMC.
Protective Effect of Quercetin against Paraquat-induced Brain Mitochondrial
Disruption in Mice
Authors: Saberi-Hasanabadi Parisa , Sedaghatnejad Reza , Mohammadi Hamidreza
Published: February 2023

Background:

Paraquat is a highly toxic quaternary ammonium herbicide widely used in
agriculture. It is an agent that induces pulmonary toxicity via the redox cyclic reaction.

Objective:

The present study investigated the protective effect of quercetin against paraquatinduced
brain mitochondria disruption in mice.

Methods:

Paraquat (1.25 mg/kg, intraperitoneally) was administered to the mice, and then quercetin
(50, 100, 200 mg/kg) was injected i.p. Oxidative damage biomarkers such as reactive oxygen
species, protein carbonyl, lipid peroxidation, glutathione content, and mitochondrial function were
assessed in the brain mitochondria.

Results:

The results showed that paraquat significantly (P < 0.001) increased the reactive oxygen
species, protein carbonyl, and lipid peroxidation and significantly (P < 0.0001) decreased the glutathione
content and mitochondrial function in the brain cells. Administration of the quercetin at
doses of 50, 100, and 200 mg/kg significantly reduced reactive oxygen species, lipid peroxidation,
and protein carbonyl and improved mitochondrial function and glutathione content in the mice
brain mitochondrial compared to the paraquat group. Quercetin at 200 mg/kg dose had better effectiveness
than 50 and 100 mg/kg doses.

Conclusion:

Our results suggest that quercetin in a dose-dependent manner has neuroprotective effects,
probably by free radicals scavenging or enhancing the antioxidant mechanisms in the brain
mitochondria. It seems that quercetin could modulate protein and lipid oxidation and improve oxidative
damage induced by paraquat in the early stages.
Antibacterial and Antioxidant Superoxide Anion Radical Inhibitors from
Myrmecodia pendans: An In silico Study
Authors: Ramadhanty Zenika Febian , Kurnia Dikdik , Situmeang Boima , Hemiawati Mieke , Asmah Nur
Published: February 2023

Background:

Background: Ant-nest (Myrmecodia pendans) is an epiphytic plant that can prevent several
diseases, including bacterial infections. Diarrhea is caused by Escherichia coli bacteria, while infections
in the oral cavity can be caused by Enterococcus faecalis bacteria. Antibacterial activity is also influenced
by conditions of Reactive Oxygen Species (ROS). Antioxidants are needed to inhibit the formation of
excess ROS in the body. Superoxide anion radicals are included in the generation of ROS, which is produced
by several enzymes, such as nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase or
commonly known as Nox and xanthine oxidase (XO).

Objective:

This study aimed to determine the potential of M. pendans as an antibacterial in vitro and in
silico correlation in the formation of superoxide anion radicals.

Methods:

The compounds were obtained by column chromatography method, followed by a spectroscopic
examination. In vitro test using the disc diffusion method and in silico test using AutoDock 4.2 program
were conducted with positive control fosfomycin and allopurinol, tethered to MurA, Nox, and XO
enzymes, and visualized using the Discovery Studio 2020.

Results:

Compound 1 (oleanolic acid) and compound 2 (pomolic acid) demonstrated antibacterial activity
against E. coli but no activity against E. faecalis. Compound 3 (3-hydroxy-eupan-20,24-dien-26-oic acid)
demonstrated no activity against these two bacteria. Based on the in silico results, compound 3 had the
best binding energy affinity for all MurA, Nox, and XO enzymes of -6.89, -9.35, and -9.75 Kcal/mol,
respectively. Similarly, compounds 1 and 2 had good binding energies for Nox protein of -9.29 Kcal/mol
and -6.54 Kcal/mol and XO of -7.66 and -4.7 Kcal/mol, respectively.

Conclusion:

In vitro results against E. coli and E. faecalis bacteria showed inhibition by compounds 1
and 2 but not by compound 3. Meanwhile, in in silico analysis, all the compounds showed potential as an
inhibitor of superoxide anion radicals generated by enzymes Nox and XO.
Microwave Synthesizer: A Biomedical Engineering Technique With
Advanced Applications
Authors: Silakari Pragati , Singh Jyoti , Sharma Shaveta
Published: February 2023

In current times, all major discoveries are believed to occur at the intersections of various
fields of science. In such a manner, perhaps the main creative region joining material science,
biology and medication is the utilization of microwave advances. In such a way, the motivation
behind this work was to explain the useful conceivable outcomes of diagnostic, analytical, synthetic
and therapeutic microwave advancements. The related exploration and uses of microwave
(MW) science are the arising methodologies of modern energy-based green science, on a nuclear
and atomic self-aggregating level. As microwaves develop the synthetic response, they have the
potential to greatly impact the chemical reaction. This technology has advanced its utilization in
the field of research technology, chemical synthesis, diagnostic chemistry, wastewater treatment,
and material science. This article cumulates the various available microwave synthesizers in the
market with their pros and cons alongside their wide applications.
Formulation and Evaluation of Herbal Hair Dye: A Laboratory Scale
Project
Authors: Syed Shoaeb Mohammad , Holkar Ajinkya , Thore Priyanka , Vaidya Sakshi
Published: February 2023

Aim:

This research was conducted to make the option for chemical-based semisynthetic
and synthetic hair dyes to overcome the problems with the use of synthetic dyes and the
acceptance rate by the public. The work involves the use of some novel natural ingredients with
novel combinations.

Methods:

The herbal hair dye was prepared y using various natural agents reported to possess
the desired properties. The plants were collected from the herbal garden of Dr. VedprakashPatil
Pharmacy College, Aurangabad & authenticated by the Dept. of Pharmacognosy. All ingredients
were passed through sieves and mixed thoroughly to get a homogenous mixture; the mixture
was dissolved in water and applied to the hairs for the evaluation of various parameters
such as organoleptic physicochemical, patch test & stability.

Results:

This Herbal hair dye prepared in the laboratory is made with all good quality materials.
It was tested in the laboratory and was found to be very safe for the regular use of this herbal
hair dye after several time intervals of time. All evaluation parameters were found to be within
the limits as prescribed for the safe use of hair dye.

Conclusion:

The prepared herbal hair dye neither shows any side effects nor skin infections. It
nourishes the skin on the scalp and hair. This herbal hair dye also aids in dandruff treatment by
removing excess oil from the scalp. If such herbal dye is used frequently or regularly, it will
give a manageable, fizz-free colored hair benefiting human as well as the industry. The formulation
is natural in origin with effective benefits compared to the marketed formulation and
cost-effective.

:

As the process is simple, small scale cosmetic industry can make use of the technique.
WITHDRAWN: Non-Anti-TNF Biologics as Salvage Therapy for Refractory Acute Severe Ulcerative Colitis, A Systematic Review
Authors: Weissman Simcha , Aziz Muhammad , Bangolo Ayrton , Zahdeh Tamer , Elias Daniel , Taneja Vikas , El-Dallal Mohammed , Nagesh Vignesh K. , Aleem Haris , Ghaffar Umar , Singla Kushaghar , Thwe Hla M. , Muthukumar Ananya , Gurumurthy Vaishnavi , Prasad Bodapati A. , Chugh Rachita , Mutabi Erasmus , Kalra Meenal , Muthineni Venkata AB. , Khota Kavya , Gade Amulya , Thompson-Edwards Ashley , Venkatesh Harini K. , Jijo Joseph P. , Salib Yousstina , Ogbu Chukwuemeka E. , Elias Sameh , Feuerstein Joseph D.
Published: February 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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Pengaruh Angin Terhadap Dimensi Rip-Rap Bendungan
Authors: Hafifah Dwi Tiya Ayu , Asmaranto Runi , Fidari Jadfan Sidqi
Published: February 2023

Rip-rap Bendungan Sengguruh berfungsi sebagai peredam energi yang dapat mereduksi hempasan ombak agar tidak terjadi penggerusan tanah pada lereng hulu bendungan. Studi ini bertujuan menganalisa potensi terjadinya gelombang air yang diakibatkan oleh angin yang dapat merusak material pada Rip-rap Bendungan Sengguruh dilihat berdasarkan tinggi gelombang yang dihasilkan serta perubahan dimensi Rip-rap yang dihitung dari metode perhitungan angin desain (VMPH). Data yang dibutuhkan yaitu kecepatan angin bulanan (U), dataarah angin yang digunakan untuk menentukan nilai panjang fetch (F), data berat jenis batuan dan kemiringan rip-rap bendungan untuk menghitung berat masing-masing fragmen batuan (W). Dari perhitungan tinggi gelombang menggunakan metode perhitungan angin desain (VMPH) tidak dihasilkan gelombang airakibat pengaruh angin pada Bendungan Sengguruh, diakibatkan nilai fetch (F) pada Bendungan Sengguruh <1 km yaitu sebesar (0,850 km). Pada penelitian kaliini tidak dijumpai pengaruh angin yang signifikan yang dapat merusak rip-rap Bendungan Sengguruh. Berdasarkan perhitungan dan dilihat dari kondisi riprap Bendungan Sengguruh saat ini masih dapat dikatakan aman dari pengaruh angin dan gelombang.
The Sengguruh Dam rip-rap functions as an energy damper that can reduce the crashing of waves so that soil erosion doesn’t occur on the upstream slopes of the dam. This study aims to analyze the potential for water waves caused by the wind that can damage the material in the Sengguruh Dam Rip-rap based on the resulting wave height and rip-rap dimensional changes calculated from the design wind calculation method (VMPH). The data needed are monthly wind speed (U), wind direction data used to determine fetch length (F), rock-specific gravity data, and dam rip-rap slope to calculate the weight of each rock fragment (W). From the calculation of wave height using the design wind calculation method (VMPH), no waves were produced due to the influence of wind on the Sengguruh Dam, due to the fetch value (F) at the Sengguruh Dam of 1 km, which is equal to 0.850 km. In this study, there is no significant wind effect that could damage the Sengguruh Dam rip-rap. Based on calculations and judging from the current rip-rap condition of the Sengguruh Dam, it could be said that it is safe from the effects of wind and waves.
Mal suramericano de las hojas en caucho
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación Colombiana de Investigación Agropecuaria, (Colombia)
Published: February 2023

En este clip se muestra en qué consiste el mal suramericano de las hojas y qué hacer frente a esta enfermedad, la cual ocasiona la pérdida de hojas y la muerte del árbol.
Mobile Phone Apps for HIV Prevention Among College-Aged Black Women in Atlanta: Mixed Methods Study and User-Centered Prototype (Preprint)
Authors: Tesema Naomi , Guillaume Dominique , Francis Sherilyn , Paul Sudeshna , Chandler Rasheeta
Published: February 2023

BACKGROUND

Black women in college are disproportionately affected by HIV diagnoses. Mobile apps can facilitate the innovative delivery of accurate HIV and sexual and reproductive health information. However, mobile health interventions are severely underused in this population.

OBJECTIVE

We aimed to quantitatively and qualitatively explore the perspectives of college-aged Black women on using a mobile health app for HIV prevention and sexual and reproductive health. The data obtained from Black women were used to design preliminary mobile app wireframes and features.

METHODS

This explanatory, sequential mixed methods study took place from 2019 to 2020 and targeted Black women who were enrolled in college or who had recently graduated from college. Convenience sampling was used during the quantitative phase, followed by purposive sampling in the qualitative phase. A cross-sectional web-based survey evaluating the willingness to use a mobile app for HIV prevention was conducted in the quantitative phase. Descriptive statistics were used for all variables. A separate focus group discussion was conducted with Black women in college to expand on the quantitative results. Focus group discussions explored their perceptions on HIV and health content delivered through a mobile app along with potential features that participants desired within the app. Using the data obtained, we selected the primary features for the app prototype.

RESULTS

In total, we enrolled 34 participants in the survey, with 6 participating in focus group discussions. Over half of the respondents reported a willingness to use an app that contained pre-exposure prophylaxis content. Women who claimed recent sexual activity reported being more likely to use an app feature that would allow them to order an at-home HIV testing kit than their non–sexually active counterparts. The emerging themes from the focus group session were Black women’s health concerns, HIV risk, sources of health information, and preferred app features. The content in our prototype included speaking with a specialist, HIV and pre-exposure prophylaxis information, holistic wellness, and features promoting engagement and retention.

CONCLUSIONS

The results of our study guided the design of wireframes for an app prototype targeting HIV prevention in college-aged Black women. The rapid growth of mobile devices in Black communities, coupled with high rates of smartphone ownership among Black youth, makes mobile health interventions a promising strategy for addressing sexual and reproductive health disparities. Participants in our sample were willing to use a culturally appropriate and gender-considerate app for their sexual health needs. Our findings indicate that Black women in college may be excellent candidates for mobile app–based interventions.
The Effect of Social Networks on Active Living in Adolescents: Qualitative Focus Group Study (Preprint)
Authors: Hermsen Sander , Van Abswoude Femke , Steenbergen Bert
Published: February 2023

BACKGROUND

Participation in organized sports and other forms of active living have important health benefits in adolescence and adulthood. Unfortunately, the transition to secondary school has been shown to be a barrier to participation. Social networks can play important roles in activating adolescents, and information and communication technology (ICT) interventions can augment this role. To date, there are few insights into what adolescents themselves think and feel about barriers to and motivators for active living, the role of their social networks in active living, and the potential of ICT for physical activity (PA).

OBJECTIVE

This study aimed to gather insights into the perspectives of adolescents aged 12 to 14 years on active living and sports participation, motivators and demotivators for active living, and the potential roles of their social network and of ICT.

METHODS

A total of 26 adolescents aged 12 to 14 years from different levels of Dutch secondary schools participated in 1 of 5 semistructured focus group interviews, in which they talked about sports and PA, their social networks, their ICT use, and the role of social networks and ICT in PA. All interviews were transcribed and analyzed using a thematic qualitative approach.

RESULTS

The study showed that all participants were physically active, although the transition to secondary school made this difficult, mostly because of time constraints. Participants saw positive physical and mental health effects as important benefits of active living. They regarded social benefits as strong motivators for active living: being together, making friends, and having fun together. However, the social network could also demotivate through negative peer judgment and negative feedback. Participants were willing to share their own positive experiences and hear about those from close peers and friends but would not share their own (and were not interested in others’) negative experiences or personal information. Participants were mainly interested in descriptive norms set by others and obtained inspiration from others for PA. With respect to using ICT for active living, participants stated a preference for social challenges among friends, personalized feedback, goals, activities, and rewards. Competition was seen as less important or even unattractive. If mentioned, participants felt that this should be with friends, or peers of a similar level, with fun being more important than the competition itself.

CONCLUSIONS

This study shows that adolescents feel that their social network is and can be a strong driver of active living. They are willing to use ICT-based solutions that make use of social networks for PA as long as these solutions involve their current (close) network and use an approach based on being together and having fun together.

CLINICALTRIAL
iCHECK-DH: Guidelines and Checklist for the Reporting on Digital Health Implementations (Preprint)
Authors: Perrin Franck Caroline , Babington-Ashaye Awa , Dietrich Damien , Bediang Georges , Veltsos Philippe , Gupta Pramendra Prasad , Juech Claudia , Kadam Rigveda , Collin Maxime , Setian Lucy , Serrano Pons Jordi , Kwankam S Yunkap , Garrette Béatrice , Barbe Solenne , Bagayoko Cheick Oumar , Mehl Garrett , Lovis Christian , Geissbuhler Antoine
Published: February 2023

BACKGROUND

Implementation of digital health technologies has grown rapidly, but many remain limited to pilot studies due to challenges, such as a lack of evidence or barriers to implementation. Overcoming these challenges requires learning from previous implementations and systematically documenting implementation processes to better understand the real-world impact of a technology and identify effective strategies for future implementation.

OBJECTIVE

A group of global experts, facilitated by the Geneva Digital Health Hub, developed the Guidelines and Checklist for the Reporting on Digital Health Implementations (iCHECK-DH, pronounced “I checked”) to improve the completeness of reporting on digital health implementations.

METHODS

A guideline development group was convened to define key considerations and criteria for reporting on digital health implementations. To ensure the practicality and effectiveness of the checklist, it was pilot-tested by applying it to several real-world digital health implementations, and adjustments were made based on the feedback received. The guiding principle for the development of iCHECK-DH was to identify the minimum set of information needed to comprehensively define a digital health implementation, to support the identification of key factors for success and failure, and to enable others to replicate it in different settings.

RESULTS

The result was a 20-item checklist with detailed explanations and examples in this paper. The authors anticipate that widespread adoption will standardize the quality of reporting and, indirectly, improve implementation standards and best practices.

CONCLUSIONS

Guidelines for reporting on digital health implementations are important to ensure the accuracy, completeness, and consistency of reported information. This allows for meaningful comparison and evaluation of results, transparency, and accountability and informs stakeholder decision-making. i-CHECK-DH facilitates standardization of the way information is collected and reported, improving systematic documentation and knowledge transfer that can lead to the development of more effective digital health interventions and better health outcomes.
A Comparative Study on the Influencing Factors of Sports Participation between Male and Female College Students
Authors: YAO TANG , YANG CHENG
Published: February 2023

The sports participation of college students is affected by many factors. Due to the physical and psychological differences between male and female college students, the factors affecting college students’ sports participation also show gender differences. An online questionnaire was distributed to students in four sports classes to investigate the influencing factors of male and female college students’ participation in sports. A total of 100 valid questionnaires were received, including 36 male college students and 64 female college students. T-test was used for analysis. The results showed that two of the 29 in investigated factors showed significant differences between men and women (p<0.05 and p<0.01). Conclusion: Male college students’ sports participation is more likely to be affected by their lovers. Male college students practice sports skills to win sports competitions stronger than female college students.
Utilization of Ceramic Waste as Coarse Aggregate and the effect on Concrete Compressive Strength
Authors: P. Papilaya Samuel.
Published: February 2023

In accordance with the development of knowledge, ceramics are all items made from non-metallic inorganic materials with silicate rock soil materials whose manufacturing process is accompanied by a combustion process at high temperatures. Seeing the potential for clay soil in Indonesia is very large, of course, many industrial activities grow so that they can provide benefits for humans, but apart from the benefits there are also impacts from industrial activities. One of the impacts of industrial activities is the waste, there are industrial wastes that can damage the environment or are environmentally friendly. The method used in this study is an experimental method, namely an experiment that aims to investigate the relationship between the compressive strength of normal concrete and concrete that uses ceramic shards as a filler material for a portion of the weight of coarse aggregate. The test objects made in this experiment were 9 samples in the form of concrete cylinders with a size of 15 cm x 30 cm which would later be tested for the compressive strength of concrete using SNI 03-2834-2000 guidelines. The research objectives were to obtain the compressive strength of concrete using ceramic waste materials as an additional coarse aggregate and to obtain the results of a comparison of normal concrete compressive strength with the compressive strength of concrete using ceramic waste materials. The compressive strength of concrete using ceramic waste material as an additional coarse aggregate with a percentage of 15% and 20% ceramic waste is as follows: Trial mix with 15% ceramic gives a compressive strength of 23.91 MPa and trial mix with ceramic 20% days gives a compressive strength of 23 .89 MPa. From the results of this test the percentage of ceramic 20% has a greater compressive strength compared to the percentage of ceramic 15% and the comparison of the compressive strength values of normal concrete and concrete using ceramics proves that the compressive strength of concrete is greater than normal concrete. big. It can be seen from the compressive strength of concrete from 0% to 15% which has an increase of 0.59 MPa and the compressive strength of slate from 0% to 20% has an increase of 0.98 MPa.
contratos públicos de las Empresas Productivas del Estado
Authors: Cancino Gómez Rodolfo
Published: February 2023

La Contratación Pública en materia energética representa un esquema de apertura comercial y promoción de la inversión extranjera mediante un marco legal especializado para regular un nuevo régimen ad hoc de contratación,  que tiene implicaciones directas con los tratados comerciales internacionales tales como el Tratado Integral y Progresista de Asociación Transpacífico (TIPAT) y el Nuevo Tratado de Libre Comercio (TMEC), los cuales interactúan de una forma u otra a través de la operación de los mismos capítulos que los conforman y se interrelacionan entre sí.  Esto significa que el sector energético que está reservado para el Estado permite la participación de privados a través de contratos públicos, pero restringir su participación en el mercado mediante modificaciones legales internas puede violentar los compromisos adoptados a nivel internacional.