bluuebunny/crossref_metadata_2025 huggingface dataset:
Binary optimal control by trust-region steepest descent
Authors: Hahn Mirko , Leyffer Sven , Sager Sebastian
Published: January 2022

We present a trust-region steepest descent method for dynamic optimal control problems with binary-valued integrable control functions. Our method interprets the control function as an indicator function of a measurable set and makes set-valued adjustments derived from the sublevel sets of a topological gradient function. By combining this type of update with a trust-region framework, we are able to show by theoretical argument that our method achieves asymptotic stationarity despite possible discretization errors and truncation errors during step determination. To demonstrate the practical applicability of our method, we solve two optimal control problems constrained by ordinary and partial differential equations, respectively, and one topological optimization problem.
Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 1
Authors: Harada Miyuki , Kimura Fuminori , Takai Yasushi , Nakajima Takeshi , Ushijima Kimio , Kobayashi Hiroaki , Satoh Toyomi , Tozawa Akiko , Sugimoto Kohei , Saji Shigehira , Shimizu Chikako , Akiyama Kyoko , Bando Hiroko , Kuwahara Akira , Furui Tatsuro , Okada Hiroshi , Kawai Koji , Shinohara Nobuo , Nagao Koichi , Kitajima Michio , Suenobu Souichi , Soejima Toshinori , Miyachi Mitsuru , Miyoshi Yoko , Yoneda Akihiro , Horie Akihito , Ishida Yasushi , Usui Noriko , Kanda Yoshinobu , Fujii Nobuharu , Endo Makoto , Nakayama Robert , Hoshi Manabu , Yonemoto Tsukasa , Kiyotani Chikako , Okita Natsuko , Baba Eishi , Muto Manabu , Kikuchi Iwaho , Morishige Ken-ichirou , Tsugawa Koichiro , Nishiyama Hiroyuki , Hosoi Hajime , Tanimoto Mitsune , Kawai Akira , Sugiyama Kazuhiko , Boku Narikazu , Yonemura Masato , Hayashi Naoko , Aoki Daisuke , Osuga Yutaka , Suzuki Nao
Published: January 2022

In 2017, the Japan Society of Clinical Oncology (JSCO) published the JSCO Clinical Practice Guidelines 2017 for Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer Patients. These were the first Japanese guidelines to address issues of oncofertility. In this field of medicine, sustained close cooperation between oncologists and reproductive specialists is essential from the diagnosis of cancer until many years after completion of cancer treatment. These JSCO guidelines were intended to guide multidisciplinary medical staff in considering the availability of fertility preservation options and to help them decide whether to provide fertility preservation to childhood, adolescent, and young adult cancer patients before treatment starts, with the ultimate goal of improving patient survivorship. The guidelines are presented as Parts 1 and 2. This article (Part 1) summarizes the goals of the guidelines and the methods used to develop them and provides an overview of fertility preservation across all oncology areas. It includes general remarks on the basic concepts surrounding fertility preservation and explanations of the impacts of cancer treatment on gonadal function by sex and treatment modality and of the options for protecting/preserving gonadal function and makes recommendations based on 4 clinical questions. Part 2 of these guidelines provides specific recommendations on fertility preservation in 8 types of cancer (gynecologic, breast, urologic, pediatric, hematologic, bone and soft tissue, brain, and digestive).
Numerical simulation on effect of irrigation conditions on water temperature distribution in a paddy field
Authors: Nishida Kazuhiro , Yoshida Shuichiro , Shiozawa Sho
Published: January 2022

Water management methods regulate water temperature in paddy fields, which affects rice growth and the environment. To understand the effect of irrigation conditions on water temperature in a paddy field, water temperature distribution under 42 different irrigation models including the use of ICT water management, which enables remote and automatic irrigation, was simulated using a physical model of heat balance. The following results were obtained: (1) Irrigation water temperature had a more significant effect on paddy water temperature close to the inlet. As the distance from the inlet increased, the water temperature converged to an equilibrium, which was determined by meteorological conditions and changes in water depth. (2) Increasing the irrigation rate with higher irrigation water amount increased the extent and magnitude of the effects of the irrigation water temperature. (3) When total irrigation water amount was the same, increasing the irrigation rate decreased the time-averaged temperature gradient effect over time across the paddy field. (4) Irrigation during the lowest and highest paddy water temperatures effectively decreased and increased the equilibrium water temperature, respectively. The results indicate that irrigation management can be used to alter and control water temperature in paddy fields, and showed the potential of ICT water management in enhancing the effect of water management in paddy fields. Our results demonstrated that a numerical simulation using a physical model for water temperature distribution is useful for revealing effective water management techniques under various irrigation methods and meteorological conditions.
Interactions Between the Nocturnal Low-Level Jets and the Urban Boundary Layer: A Case Study over London
Authors: Tsiringakis Aristofanis , Theeuwes Natalie E. , Barlow Janet F. , Steeneveld Gert-Jan
Published: January 2022

Understanding the physical processes that affect the turbulent structure of the nocturnal urban boundary layer (UBL) is essential for improving forecasts of air quality and the air temperature in urban areas. Low-level jets (LLJs) have been shown to affect turbulence in the nocturnal UBL. We investigate the interaction of a mesoscale LLJ with the UBL during a 60-h case study. We use observations from two Doppler lidars and results from two high-resolution numerical-weather-prediction models (Weather Research and Forecasting model, and the Met Office Unified Model for limited-area forecasts for the U.K.) to study differences in the occurrence frequency, height, wind speed, and fall-off of LLJs between an urban (London, U.K.) and a rural (Chilbolton, U.K.) site. The LLJs are elevated ($$\approx $$
≈
70 m) over London, due to the deeper UBL, while the wind speed and fall-off are slightly reduced with respect to the rural LLJ. Utilizing two idealized experiments in the WRF model, we find that topography strongly affects LLJ characteristics, but there is still a substantial urban influence. Finally, we find that the increase in wind shear under the LLJ enhances the shear production of turbulent kinetic energy and helps to maintain the vertical mixing in the nocturnal UBL.
Inflammatory breast cancer defined: proposed common diagnostic criteria to guide treatment and research
Authors: Jagsi R. , Mason G. , Overmoyer B. A. , Woodward W. A. , Badve S. , Schneider R. J. , Lang J. E. , Alpaugh M. , Williams K. P. , Vaught D. , Smith A. , Smith K. , Miller K. D. ,   Susan G. Komen-IBCRF IBC Collaborative in partnership with the Milburn Foundation
Published: January 2022

Purpose

Inflammatory breast cancer is a deadly and aggressive type of breast cancer. A key challenge relates to the need for a more detailed, formal, objective definition of IBC, the lack of which compromises clinical care, hampers the conduct of clinical trials, and hinders the search for IBC-specific biomarkers and treatments because of the heterogeneity of patients considered to have IBC.

Methods

Susan G. Komen, the Inflammatory Breast Cancer Research Foundation, and the Milburn Foundation convened patient advocates, clinicians, and researchers to review the state of IBC and to propose initiatives to advance the field. After literature review of the defining clinical, pathologic, and imaging characteristics of IBC, the experts developed a novel quantitative scoring system for diagnosis.

Results

The experts identified through consensus several “defining characteristics” of IBC, including factors related to timing of onset and specific symptoms. These reflect common pathophysiologic changes, sometimes detectable on biopsy in the form of dermal lymphovascular tumor emboli and often reflected in imaging findings. Based on the importance and extent of these characteristics, the experts developed a scoring scale that yields a continuous score from 0 to 48 and proposed cut-points for categorization that can be tested in subsequent validation studies.

Conclusion

To move beyond subjective ‘clinical diagnosis’ of IBC, we propose a quantitative scoring system to define IBC, based on clinical, pathologic, and imaging features. This system is intended to predict outcome and biology, guide treatment decisions and inclusion in clinical trials, and increase diagnostic accuracy to aid basic research; future validation studies are necessary to evaluate its performance.
Shaming of Tax Evaders: Empirical Evidence on Perceptions of Retributive Justice and Tax Compliance Intentions
Authors: Okafor Oliver Nnamdi
Published: January 2022

Although naming-and-shaming (shaming) is a commonly used tax enforcement mechanism, little is known about the efficacy of shaming tax evaders. Through two experiments, this study examines the effects of shaming tax evaders on third-party observers’ perceptions of retributive justice and tax compliance intentions, and whether the salience of persuasion of observers moderates these relationships. Based on insights from defiance theory, the message learning model, and persuasive communications, this study predicts and finds that shaming evaders increases observers’ tax compliance intentions. Furthermore, the results show that higher persuasion, which includes sanction and normative appeals, affects observers’ tax compliance intentions. This study also suggests that shaming has a positive effect on perceptions of retributive justice. Importantly, the results reveal that perceptions of retributive justice in shaming punishment mediate the effect of shaming on tax compliance intentions. The implications for theory and practice are discussed.
Mercury toxicity risk and corticosterone levels across the breeding range of the Yellow-breasted Chat
Authors: Mancuso Kristen , Hodges Karen E. , Grosselet Manuel , Elliott John E. , Alexander John D. , Zanuttig Michelle , Bishop Christine A.
Published: January 2022

Mercury (Hg) is an environmental contaminant that can negatively impact human and wildlife health. For songbirds, Hg risk may be elevated near riparian habitats due to the transfer of methylmercury (MeHg) from aquatic to terrestrial food webs. We measured Hg levels in tail feathers sampled across the breeding range of the Yellow-breasted Chat (Icteria virens), a riparian songbird species of conservation concern. We assessed the risk of Hg toxicity based on published benchmarks. Simultaneously, we measured corticosterone, a hormone implicated in the stress response system, released via the hypothalamus-pituitary-adrenal axis. To better understand range-wide trends in Hg and corticosterone, we examined whether age, sex, subspecies, or range position were important predictors. Lastly, we examined whether Hg and corticosterone were correlated. Hg levels in chats were relatively low: 0.30 ± 0.02 µg/g dry weight. 148 out of 150 (98.6%) had Hg levels considered background, and 2 (1.6%) had levels considered low toxicity risk. Hg levels were similar between sexes and subspecies. Younger chats (<1 year) had higher Hg levels than older chats (>1 year). Hg levels were lowest in the northern and central portion of the eastern subspecies’ range. Corticosterone concentrations in feathers averaged 3.68 ± 0.23 pg/mm. Corticosterone levels were similar between ages and sexes. Western chats had higher levels of corticosterone than eastern chats. Hg and corticosterone were not correlated, suggesting these low Hg burdens did not affect the activity of the hypothalamus-pituitary-adrenal axis. Altogether, the chat has low Hg toxicity risk across its breeding range, despite living in riparian habitats.
Genetic diversity of Cryphonectria parasitica causing chestnut blight in South Tyrol (northern Italy)
Authors: Ahmad Farooq , Baric Sanja
Published: January 2022

European chestnut (Castanea sativa) is threatened by the invasive fungus Cryphonectria parasitica, which causes chestnut blight. The virulence of the fungus can be reduced by a group of mycoviruses that can spread among vegetatively compatible strains through hyphal anastomosis. Hypovirulent isolates are used as biocontrol agents, but their efficiency can be diminished by restricted hyphal anastomosis if the variability of vegetative compatibility (vc) types in a population is high. Sexual reproduction could increase the vc type diversity and further complicate biocontrol in a region. Therefore, knowledge of genetic diversity of C. parasitica is important to assess the effectiveness of a biological control program. The present study was performed in the Autonomous Province of Bozen-Bolzano (South Tyrol) in northern Italy, where chestnut cultivation provides an additional income to farmers. The genetic characterization of C. parasitica isolates from 35 chestnut stands and one forest population in different districts of South Tyrol was performed based on the analysis of vegetative incompatibility loci, the mating type locus, and the internal transcribed spacer (ITS) region. In this study, a total of 23 different vc types were found all over South Tyrol with a Shannon diversity index of 1.86. EU-2, EU-1, and EU-13 were the most widespread vc types comprising 51%, 13%, and 9% of the fungal isolates, respectively. Both mating types were present in the region with a ratio close to 1:1. Three different haplotypes were identified based on ITS sequence analysis, which pointed to two introduction events of the fungus to the region and allowed placing C. parasitica from South Tyrol into a larger phylogeographic context.
Metagenomic monitoring of soil bacterial community after the construction of a crude oil flowline
Authors: Bonomo Maria Grazia , Calabrone Luana , Scrano Laura , Bufo Sabino Aurelio , Di Tomaso Katia , Buongarzone Euro , Salzano Giovanni
Published: January 2022

This study aimed to assess the metagenomic changes of soil bacterial community after constructing a crude oil flowline in Basilicata region, Italy. Soils identified a total of 56 taxa at the phylum level and 485 at the family level, with a different taxa distribution, especially in samples collected on 2014. Since microbiological diversity occurred in the soils collected after 2013 (the reference year), we performed a differential abundance analysis using DESeq2 by GAIA pipeline. In the forest area, 14 phyla and 126 families were differentially abundant (− 6.06 < logFC > 7.88) in 2014 compared to 2013. Nine families were differentially abundant in 2015, with logFC between − 3.16 and 4.66, while 20 families were significantly more abundant and 16 less abundant in 2016, with logFC between − 6.48 and 6.45. In the cultivated area, 33 phyla and 260 families showed differential abundance in 2014. In the next year (2015), 14 phyla were significantly more abundant and 19 less abundant, while 29 families were substantially more abundant and 139 less abundant, with fold changes ranging between − 5.67 and 4.01. In 2016, 33 phyla showed a significantly different abundance, as 14 were more abundant and 19 decreased, and 81 families showed a significantly increased amount with logFC between − 5.31 and 5.38. These results hypothesise that the analysed site is an altered soil where the development of particular bacterial groups attends to bioremediation processes, naturally occurring to restore optimal conditions.
Systemic deficiency of GM1 ganglioside in Parkinson’s disease tissues and its relation to the disease etiology
Authors: Ledeen Robert , Chowdhury Suman , Lu Zi-Hua , Chakraborty Monami , Wu Gusheng
Published: January 2022

Following our initial reports on subnormal levels of GM1 in the substantia nigra and occipital cortex of Parkinson’s disease (PD) patients, we have examined additional tissues from such patients and found these are also deficient in the ganglioside. These include innervated tissues intimately involved in PD pathology such as colon, heart and others, somewhat less intimately involved, such as skin and fibroblasts. Finally, we have analyzed GM1 in peripheral blood mononuclear cells, a type of tissue apparently with no direct innervation, and found those too to be deficient in GM1. Those patients were all afflicted with the sporadic form of PD (sPD), and we therefore conclude that systemic deficiency of GM1 is a characteristic of this major type of PD. Age is one factor in GM1 decline but is not sufficient; additional GM1 suppressive factors are involved in producing sPD. We discuss these and why GM1 replacement offers promise as a disease-altering therapy.
Tracking Hunter-Gatherer Impact on Vegetation in Last Interglacial and Holocene Europe: Proxies and Challenges
Authors: Nikulina Anastasia , MacDonald Katharine , Scherjon Fulco , A. Pearce Elena , Davoli Marco , Svenning Jens-Christian , Vella Emily , Gaillard Marie-José , Zapolska Anhelina , Arthur Frank , Martinez Alexandre , Hatlestad Kailin , Mazier Florence , Serge Maria Antonia , Lindholm Karl-Johan , Fyfe Ralph , Renssen Hans , Roche Didier M. , Kluiving Sjoerd , Roebroeks Wil
Published: January 2022

We review palaeoenvironmental proxies and combinations of these relevant for understanding hunter-gatherer niche construction activities in pre-agricultural Europe. Our approach consists of two steps: (1) identify the possible range of hunter-gatherer impacts on landscapes based on ethnographic studies; (2) evaluate proxies possibly reflecting these impacts for both the Eemian (Last Interglacial, Middle Palaeolithic) and the Early–Middle Holocene (Mesolithic). We found these paleoenvironmental proxies were not able to unequivocally establish clear-cut differences between specific anthropogenic, climatic and megafaunal impacts for either time period in this area. We discuss case studies for both periods and show that published evidence for Mesolithic manipulation of landscapes is based on the interpretation of comparable data as available for the Last Interglacial. If one applies the ‘Mesolithic’ interpretation schemes to the Neanderthal record, three common niche construction activities can be hypothesised: vegetation burning, plant manipulation and impact on animal species presence and abundance. Our review suggests that as strong a case can be made for a Neanderthal impact on landscapes as for anthropogenic landscape changes during the Mesolithic, even though the Neanderthal evidence comes from only one high-resolution site complex. Further research should include attempts (e.g. by means of modelling studies) to establish whether hunter-gatherer impact on landscapes played out at a local level only versus at a larger scale during both time periods, while we also need to obtain comparative data on the population sizes of Last Interglacial and Holocene hunter-gatherers, as these are usually inferred to have differed significantly.
Spatial distribution of turbulent diapycnal mixing along the Mindanao current inferred from rapid-sampling Argo floats
Authors: He Ying , Wang Jianing , Wang Fan , Hibiya Toshiyuki
Published: January 2022

The Mindanao Current (MC) bridges the North Pacific low-latitude western boundary current system region and the Indonesian Seas by supplying the North Pacific waters to the Indonesian Throughflow. Although the previous study speculated that the diapycnal mixing along the MC might be strong on the basis of the water mass analysis of the gridded climatologic dataset, the real spatial distribution of diapycnal mixing along the MC has remained to be clarified. We tackle this question here by applying a finescale parameterization to temperature and salinity profiles obtained using two rapid-sampling profiling Argo floats that drifted along the MC. The western boundary (WB) region close to the Mindanao Islands and the Sangihe Strait are the two mixing hotspots along the MC, with energy dissipation rate ε and diapycnal diffusivity Kρ enhanced up to ~ 10–6 W kg−1 and ~ 10–3 m2 s−1, respectively. Except for the above two mixing hotspots, the turbulent mixing along the MC is mostly weak, with ε and Kρ to be 10–11–10–9 W kg−1 and 10–6–10–5 m2 s−1, respectively. Strong mixing in the Sangihe Strait can be basically attributed to the existence of internal tides, whereas strong mixing in the WB region suggests the existence of internal lee waves. We also find that water mass transformation along the MC mainly occurs in the Sangihe Strait where the water masses are subjected to strong turbulent mixing during a long residence time.
A Multi‑Center, Open‑Label, Single‑Arm Trial to Evaluate the Efficacy, Pharmacokinetics, and Safety and Tolerability of IGSC 20% in Subjects with Primary Immunodeficiency
Authors: Santamaria Manuel , Neth Olaf , Douglass Jo A. , Krivan Gergely , Kobbe Robin , Bernatowska Ewa , Grigoriadou Sofia , Bethune Claire , Chandra Anita , Horneff Gerd , Borte Michael , Sonnenschein Anja , Kralickova Pavlina , Ramón Silvia Sánchez , Langguth Daman , Gonzalez-Granado Luis Ignacio , Alsina Laia , Querolt Montse , Griffin Rhonda , Hames Carrie , Mondou Elsa , Price Jeffrey , Sanz Ana , Lin Jiang
Published: January 2022

Purpose

The purpose of this phase 3 study was to evaluate the efficacy, pharmacokinetics (PK), and safety of Immune Globulin Subcutaneous (Human), 20% Caprylate/Chromatography Purified (IGSC 20%) in patients with primary immunodeficiency (PI).

Methods

Immunoglobulin treatment-experienced subjects with PI received 52 weeks of IGSC 20% given weekly at the same dose as the subject’s previous IgG regimen (DAF 1:1); the minimum dose was 100 mg/kg/week. The primary endpoint was serious bacterial infections (SBIs [null vs alternative hypothesis: SBI rate per person per year ≥ 1 vs < 1]). IgG subclasses and specific pathogen antibody levels were also measured.

Results

Sixty-one subjects (19 children [≤ 12 years], 10 adolescents [> 12–16 years], and 32 adults) were enrolled. The rate of SBIs per person per year was 0.017. The 1-sided 99% upper confidence limit was 0.036 (< 1), and the null hypothesis was rejected. The rate of hospitalization due to infection per person per year was 0.017 (2-sided 95% confidence interval: 0.008–0.033) overall. The mean trough total IgG concentrations were comparable to the previous IgG replacement regimen. The average of the individual mean trough ratios (IGSC 20%:previous regimen) was 1.078 (range: 0.83–1.54). The average steady-state mean trough IgG concentrations were 947.64 and 891.37 mg/dL, respectively. Seven subjects had serious treatment-emergent adverse events (TEAEs); none was drug-related. The rate of all TEAEs, including local infusion site reactions, during 3045 IGSC 20% infusions was 0.135. Most TEAEs were mild or moderate.

Conclusions

IGSC 20% demonstrated efficacy and good safety and tolerability in subjects with PI.
Prevalence of Pathogenic and Potentially Pathogenic Inborn Error of Immunity Associated Variants in Children with Severe Sepsis
Authors: Kernan Kate F. , Ghaloul-Gonzalez Lina , Vockley Jerry , Lamb Janette , Hollingshead Deborah , Chandran Uma , Sethi Rahil , Park Hyun-Jung , Berg Robert A. , Wessel David , Pollack Murray M. , Meert Kathleen L. , Hall Mark W. , Newth Christopher J. L. , Lin John C. , Doctor Allan , Shanley Tom , Cornell Tim , Harrison Rick E. , Zuppa Athena F. , Banks Russel , Reeder Ron W. , Holubkov Richard , Notterman Daniel A. , Dean J. Michael , Carcillo Joseph A.
Published: January 2022

Purpose

Our understanding of inborn errors of immunity is increasing; however, their contribution to pediatric sepsis is unknown.

Methods

We used whole-exome sequencing (WES) to characterize variants in genes related to monogenic immunologic disorders in 330 children admitted to intensive care for severe sepsis. We defined candidate variants as rare variants classified as pathogenic or potentially pathogenic in QIAGEN’s Human Gene Mutation Database or novel null variants in a disease-consistent inheritance pattern. We investigated variant correlation with infection and inflammatory phenotype.

Results

More than one in two children overall and three of four African American children had immunodeficiency-associated variants. Children with variants had increased odds of isolating a blood or urinary pathogen (blood: OR 2.82, 95% CI: 1.12–7.10, p = 0.023, urine: OR: 8.23, 95% CI: 1.06–64.11, p = 0.016) and demonstrating increased inflammation with hyperferritinemia (ferritin $$\ge 500$$

≥
500

ng/mL, OR: 2.16, 95% CI: 1.28–3.66, p = 0.004), lymphopenia (lymphocyte count < 1000/µL, OR: 1.66, 95% CI: 1.06 – 2.60, p = 0.027), thrombocytopenia (platelet count < 150,000/µL, OR: 1.76, 95% CI: 1.12–2.76, p = 0.013), and CRP greater than 10 mg/dl (OR: 1.71, 95% CI: 1.10–2.68, p = 0.017). They also had increased odds of requiring extracorporeal membrane oxygenation (ECMO, OR: 4.19, 95% CI: 1.21–14.5, p = 0.019).

Conclusion

Herein, we describe the genetic findings in this severe pediatric sepsis cohort and their microbiologic and immunologic significance, providing evidence for the phenotypic effect of these variants and rationale for screening children with life-threatening infections for potential inborn errors of immunity.
Minimizing sevoflurane wastage by sensible use of automated gas control technology in the flow-i workstation: an economic and ecological assessment
Authors: Kalmar Alain F. , Van Der Vekens Nicky , De Rydt Fréderic , Allaert Silvie , Van De Velde Marc , Mulier Jan
Published: January 2022

Both ecological and economic considerations dictate minimising wastage of volatile anaesthetics. To reconcile apparent opposing stakes between ecological/economical concerns and stability of anaesthetic delivery, new workstations feature automated software that continually optimizes the FGF to reliably obtain the requested gas mixture with minimal volatile anaesthetic waste. The aim of this study is to analyse the kinetics and consumption pattern of different approaches of sevoflurane delivery with the same 2% end-tidal goal in all patients. The consumption patterns of sevoflurane of a Flow-i were retrospectively studied in cases with a target end-tidal sevoflurane concentration (Etsevo) of 2%. For each setting, 25 cases were included in the analysis. In Automatic Gas Control (AGC) regulation with software version V4.04, a speed setting 6 was observed; in AGC software version V4.07, speed settings 2, 4, 6 and 8 were observed, as well as a group where a minimal FGF was manually pursued and a group with a fixed 2 L/min FGF. In 45 min, an average of 14.5 mL was consumed in the 2L-FGF group, 5.0 mL in the minimal-manual group, 7.1 mL in the AGC4.04 group and 6.3 mL in the AGC4.07 group. Faster speed AGC-settings resulted in higher consumption, from 6.0 mL in speed 2 to 7.3 mL in speed 8. The Etsevo target was acquired fastest in the 2L-FGF group and the Etsevo was more stable in the AGC groups and the 2L-FGF groups. In all AGC groups, the consumption in the first 8 min was significantly higher than in the minimal flow group, but then decreased to a comparable rate. The more recent AGC4.07 algorithm was more efficient than the older AGC4.04 algorithm. This study indicates that the AGC technology permits very significant economic and ecological benefits, combined with excellent stability and convenience, over conventional FGF settings and should be favoured. While manually regulated minimal flow is still slightly more economical compared to the automated algorithm, this comes with a cost of lower precision of the Etsevo. Further optimization of the AGC algorithms, particularly in the early wash-in period seems feasible. In AGC mode, lower speed settings result in significantly lower consumption of sevoflurane. Routine clinical practice using what historically is called “low flow anaesthesia” (e.g. 2 L/min FGF) should be abandoned, and all anaesthesia machines should be upgraded as soon as possible with automatic delivery technology to minimize atmospheric pollution with volatile anaesthetics.
Longitudinal Assessment of a Manualized Group Treatment Program for Gambling Disorder: The Ohio Problem Gambling Treatment Model for Adults with Co-Occurring Disorders
Authors: Kruse-Diehr Aaron J. , Shamblen Stephen R. , Courser Matthew W.
Published: January 2022

Individuals with gambling disorder (GD) experience a host of negative psychosocial and physical health outcomes, yet few seek treatment. Of particular concern are individuals with co-occurring mental and behavioral health disorders, a group at higher risk for GD in the state of Ohio. To better serve this population, the Ohio Department of Mental Health and Addiction Services developed a group-based GD treatment manual for adults with co-occurring disorders. Over the course of 5 years, 353 individuals engaged in at least some of the manual’s 12 weekly modules, and more than one-third (n = 122) completed the entire curriculum. Participants who completed all 12 modules completed pre-and post-tests, and after controlling for covariates, participants significantly decreased their GD symptom severity, though changes in self-esteem and gambling urges were non-significant. These findings suggest the treatment manual holds promise at reducing gambling behaviors for individuals with co-occurring disorders, but further research is warranted to explore best practices on how to intervene on the psychological antecedents to gambling in this population.
In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells
Authors: Kurosaki Yoshifumi , Imoto Akemi , Kawakami Fumitaka , Ouchi Motoshi , Morita Asuka , Yokoba Masanori , Takenaka Tsuneo , Ichikawa Takafumi , Katagiri Masato , Nielsen Rikke , Ishii Naohito
Published: January 2022

Bardoxolone methyl [methyl-2-cyano-3, 12-dioxooleana-1, 9(11)dien-28-oate (CDDO-Me)], an activator of the nuclear factor erythroid-derived 2-related factor2 pathway, is a potential therapeutic candidate for the treatment of kidney diseases. However, its effect against cellular senescence remains unclear. This study aimed to investigate whether CDDO-Me protects cells against cisplatin-induced cellular senescence using an in vitro model. The human renal proximal tubular epithelial cell line HK-2 was treated with cisplatin for 6 h, followed by treatment with or without CDDO-Me (0.1 or 0.2 μmol/L). Senescence markers were analyzed using western blotting and real-time PCR. Apoptosis was evaluated through TUNEL staining. Cisplatin induced changes in the levels of markers specific for proliferation, cell cycle, and senescence in a time- and dose-dependent manner. Furthermore, IL-6 and IL-8 levels in the culture medium increased markedly. These data suggested that cellular senescence-like alterations occurred in HK-2 cells exposed to cisplatin. CDDO-Me treatment reversed the cisplatin-mediated alterations in the levels of cellular senescence markers. The antioxidant enzymes, HO1, NQO1, GPX1, and CAT were upregulated by CDDO-Me treatment. Furthermore, CDDO-Me treatment induced apoptosis in cisplatin-exposed HK-2 cells. Pretreatment with Ac-DEVD-CHO, the caspase inhibitor, suppressed the reversal effect of CDDO-Me against cisplatin-induced cellular senescence-like alterations. This study showed that CDDO-Me attenuated cisplatin-induced premature senescence of HK-2 cells. This beneficial effect may be related to Nrf2 activation. Our findings also showed that CDDO-Me induced apoptosis in cisplatin-treated HK-2 cells, potentially protecting the kidneys from cellular senescence. CDDO-Me appears to be a candidate treatment for acute kidney injury.
Enhancement of light field disparity maps by reducing the silhouette effect and plane noise
Authors: Lourenco Rui M. , Tavora Luis M. N. , Assuncao Pedro A. A. , Thomaz Lucas A. , Fonseca-Pinto Rui , Faria Sergio M. M.
Published: January 2022

During the last decade, there has been an increasing number of applications dealing with multidimensional visual information, either for 3D object representation or feature extraction purposes. In this context, recent advances in light field technology, have been driving research efforts in disparity estimation methods. Among the existing ones, those based on the structure tensor have emerged as very promising to estimate disparity maps from Epipolar Plane Images. However, this approach is known to have two intrinsic limitations: (i) silhouette enlargement and (ii) irregularity of surface normal maps as computed from the estimated disparity. To address these problems, this work proposes a new method for improving disparity maps obtained from the structure-tensor approach by enhancing the silhouette and reducing the noise of planar surfaces in light fields. An edge-based approach is initially used for silhouette improvement through refinement of the estimated disparity values around object edges. Then, a plane detection algorithm, based on a seed growth strategy, is used to estimate planar regions, which in turn are used to guide correction of erroneous disparity values detected in object boundaries. The proposed algorithm shows an average improvement of 98.3% in terms of median angle error for plane surfaces, when compared to regular structure-tensor-based methods, outperforming state-of-the-art methods. The proposed framework also presents very competitive results, in terms of mean square error between disparity maps and their ground truth, when compared with their counterparts.
Multi-risk assessment in a historical city
Authors: Arrighi C. , Tanganelli M. , Cristofaro M. T. , Cardinali V. , Marra A. , Castelli F. , De Stefano M.
Published: January 2022

Natural hazards pose a significant threat to historical cities which have an authentic and universal value for mankind. This study aims at codifying a multi-risk workflow for seismic and flood hazards, for site-scale applications in historical cities, which provides the Average Annual Loss for buildings within a coherent multi-exposure and multi-vulnerability framework. The proposed methodology includes a multi-risk correlation and joint probability analysis to identify the role of urban development in re-shaping risk components in historical contexts. The workflow is unified by exposure modelling which adopts the same assumptions and parameters. Seismic vulnerability is modelled through an empirical approach by assigning to each building a vulnerability value depending on the European Macroseismic Scale (EMS-98) and modifiers available in literature. Flood vulnerability is modelled by means of stage-damage curves developed for the study area and validated against ex-post damage claims. The method is applied to the city centre of Florence (Italy) listed as UNESCO World Heritage site since 1982. Direct multi-hazard, multi-vulnerability losses are modelled for four probabilistic scenarios. A multi-risk of 3.15 M€/year is estimated for the current situation. In case of adoption of local mitigation measures like floodproofing of basements and installation of steel tie rods, multi-risk reduces to 1.55 M€/yr. The analysis of multi-risk correlation and joint probability distribution shows that the historical evolution of the city centre, from the roman castrum followed by rebuilding in the Middle Ages, the late XIX century and the post WWII, has significantly affected multi-risk in the area. Three identified portions of the study area with a different multi-risk spatial probability distribution highlight that the urban development of the historical city influenced the flood hazard and the seismic vulnerability. The presented multi-risk workflow could be applied to other historical cities and further extended to other natural hazards.
Spatiotemporal variation in global floods with different affected areas and the contribution of influencing factors to flood-induced mortality (1985–2019)
Authors: Liu Tian , Shi Peijun , Fang Jian
Published: January 2022

Floods are great threats to human life and property. Extensive research has investigated the spatiotemporal variation in flood occurrence, while few have studied the heterogeneity in global flood events of different sizes, which may require different coping strategies and risk reduction policies. In this study, we analysed the spatiotemporal patterns of global flood events with different affected areas (classified in three levels) during 1985–2019 and examined the contribution of different influencing factors to flood-induced mortality using Geodetector. The results show that (1) the increase in global flood frequency was mainly caused by Level II and Level III floods, and the average area affected by flood events has been increasing yearly since 1985. (2) In America and Africa, the frequency of Level III floods has increased monotonically. At the same time, the frequency of Level I floods in Europe and Level II floods in Asia has increased significantly. (3) For Europe and Asia, most of the deaths occurred with Level II floods; while for America and Africa, Level III floods caused the most mortality. (4) The top three factors contributing to the spatial heterogeneity in flood-induced mortality were the affected population, GDP per capita and flood duration. The contribution of each factor varied among the different types of floods. Topographic factors (percentage of mountainous area) magnified flood-induced mortality during extreme events with heavy rainfall, especially for Level III floods. The heterogeneity in flood frequency and flood-induced mortality indicates that flood protection measures should be more targeted. In addition, the increase in large-scale floods (Level III) highlights the need for transregional cooperation in flood risk management.
Customer Satisfaction with Branch Office Services in Higashihiroshima, Hiroshima Prefecture
Authors: Moteki Yasutoshi
Published: January 2022

This study empirically investigates the major factors that determine customer satisfaction in local government offices in Japan by using three categories of questions. They referred to customer satisfaction studies worldwide, especially to the expectancy disconfirmation model, the SERVQUAL model, and subsequent methods that emphasize customer’s direct experience. The on-site surveys were conducted at the Kurose branch office in Higashihiroshima City. A total of 240 responses were obtained over six weekdays. The regression analysis showed that staff responses and explanations were the most influential, followed by aspects related to the physical office and service delivery quality (adjusted R2 value of .51).
Determining nitrogen deficiencies for maize using various remote sensing indices
Authors: Burns Brayden W. , Green V. Steven , Hashem Ahmed A. , Massey Joseph H. , Shew Aaron M. , Adviento-Borbe M. Arlene A. , Milad Mohamed
Published: January 2022

Determining a precise nitrogen fertilizer requirement for maize in a particular field and year has proven to be a challenge due to the complexity of the nitrogen inputs, transformations and outputs in the nitrogen cycle. Remote sensing of maize nitrogen deficiency may be one way to move nitrogen fertilizer applications closer to the specific nitrogen requirement. Six vegetation indices [normalized difference vegetation index (NDVI), green normalized difference vegetation index (GNDVI), red-edge normalized difference vegetation index (RENDVI), triangle greenness index (TGI), normalized area vegetation index (NAVI) and chlorophyll index-green (CIgreen)] were evaluated for their ability to detect nitrogen deficiency and predict grain maize grain yield. Strip trials were established at two locations in Arkansas, USA, with nitrogen rate as the primary treatment. Remote sensing data was collected weekly with an unmanned aerial system (UAS) equipped with a multispectral and thermal sensor. Relationships among index value, nitrogen fertilizer rate and maize growth stage were evaluated. Green NDVI, RENDVI and CIgreen had the strongest relationship with nitrogen fertilizer treatment. Chlorophyll Index-green and GNDVI were the best predictors of maize grain yield early in the growing season when the application of additional nitrogen was still agronomically feasible. However, the logistics of late season nitrogen application must be considered.
Extraction of transforming sequences and sentence histories from writing process data: a first step towards linguistic modeling of writing
Authors: Mahlow Cerstin , Ulasik Malgorzata Anna , Tuggener Don
Published: January 2022

Producing written texts is a non-linear process: in contrast to speech, writers are free to change already written text at any place at any point in time. Linguistic considerations are likely to play an important role, but so far, no linguistic models of the writing process exist. We present an approach for the analysis of writing processes with a focus on linguistic structures based on the novel concepts of transforming sequences, text history, and sentence history. The processing of raw keystroke logging data and the application of natural language processing tools allows for the extraction and filtering of product and process data to be stored in a hierarchical data structure. This structure is used to re-create and visualize the genesis and history for a text and its individual sentences. Focusing on sentences as primary building blocks of written language and full texts, we aim to complement established writing process analyses and, ultimately, to interpret writing timecourse data with respect to linguistic structures. To enable researchers to explore this view, we provide a fully functional implementation of our approach as an open-source software tool and visualizations of the results. We report on a small scale exploratory study in German where we used our tool. The results indicate both the feasibility of the approach and that writers actually revise on a linguistic level. The latter confirms the need for modeling written text production from the perspective of linguistic structures beyond the word level.
Can differences in publisher size account for the relatively low prices of the journals available to master’s universities through commercial publishers’ databases? The importance of price discrimination and substitution effects
Authors: Walters William H.
Published: January 2022

Using price quotes and invoices for thousands of full-text databases and single-journal subscriptions, this study confirms that for a typical master’s university, the journals acquired through commercial publishers’ databases cost substantially less than those acquired through the databases of scholarly societies, universities, and other nonprofits. Moreover, the lower prices of commercial publishers’ journals cannot be readily attributed to publisher size (number of journals published) or to any of several other explanatory variables. There is a weak, direct association between publisher size and price among the for-profit journals but a stronger, inverse relationship between publisher size and price among the nonprofit journals. These findings, along with the results of previous research, suggest that resource providers may have incentives to keep prices low due to the collection development strategies adopted by many teaching-oriented colleges and universities. If the library’s goal is to hold a sufficient number of high-quality journals rather than to provide immediate access to every wanted journal, particular journals and databases may be regarded as substitutes even when each product provides unique content. Many U.S. bachelor’s and master’s institutions have goals different from those of the major research universities, and commercial publishers (along with some of the larger nonprofits) seem to recognize this when setting and negotiating prices.
Human pose, hand and mesh estimation using deep learning: a survey
Authors: Toshpulatov Mukhiddin , Lee Wookey , Lee Suan , Haghighian Roudsari Arousha
Published: January 2022

Human pose estimation is one of the issues that have gained many benefits from using state-of-the-art deep learning-based models. Human pose, hand and mesh estimation is a significant problem that has attracted the attention of the computer vision community for the past few decades. A wide variety of solutions have been proposed to tackle the problem. Deep Learning-based approaches have been extensively studied in recent years and used to address several computer vision problems. However, it is sometimes hard to compare these methods due to their intrinsic difference. This paper extensively summarizes the current deep learning-based 2D and 3D human pose, hand and mesh estimation methods with a single or multi-person, single or double-stage methodology-based taxonomy. The authors aim to make every step in the deep learning-based human pose, hand and mesh estimation techniques interpretable by providing readers with a readily understandable explanation. The presented taxonomy has clearly illustrated current research on deep learning-based 2D and 3D human pose, hand and mesh estimation. Moreover, it also provided dataset and evaluation metrics for both 2D and 3DHPE approaches.
Chemical Compositions in Modified Salinity Waterflooding of Calcium Carbonate Reservoirs: Experiment
Authors: Yutkin M. P. , Radke C. J. , Patzek T. W.
Published: January 2022

Modified or low-salinity waterflooding of carbonate oil reservoirs is of considerable economic interest because of potentially inexpensive incremental oil production. The injected modified brine changes the surface chemistry of the carbonate rock and crude oil interfaces and detaches some of adhered crude oil. Composition design of brine modified to enhance oil recovery is determined by labor-intensive trial-and-error laboratory corefloods. Unfortunately, limestone, which predominantly consists of aqueous-reactive calcium carbonate, alters injected brine composition by mineral dissolution/precipitation. Accordingly, the rock reactivity hinders rational design of brines tailored to improve oil recovery. Previously, we presented a theoretical analysis of 1D, single-phase brine injection into calcium carbonate-rock that accounts for mineral dissolution, ion exchange, and dispersion (Yutkin et al. in SPE J 23(01):084–101, 2018. 10.2118/182829-PA). Here, we present the results of single-phase waterflood-brine experiments that verify the theoretical framework. We show that concentration histories eluted from Indiana limestone cores possess features characteristic of fast calcium carbonate dissolution, 2:1 ion exchange, and high dispersion. The injected brine reaches chemical equilibrium inside the porous rock even at injection rates higher than 3.5 $$\times$$
×
10$$^{-3}$$

-
3

 m s$$^{-1}$$

-
1

(1000 ft/day). Ion exchange results in salinity waves observed experimentally, while high dispersion is responsible for long concentration history tails. Using the verified theoretical framework, we briefly explore how these processes modify aqueous-phase composition during the injection of designer brines into a calcium-carbonate reservoir. Because of high salinity of the initial and injected brines, ion exchange affects injected concentrations only in high surface area carbonates/limestones, such as chalks. Calcium-carbonate dissolution only affects aqueous solution pH. The rock surface composition is affected by all processes.