bluuebunny/crossref_metadata_2025 huggingface dataset:
GalICS 2.1: a new semianalytic model for cold accretion, cooling, feedback, and their roles in galaxy formation
Authors: Cattaneo A , Koutsouridou I , Tollet E , Devriendt J , Dubois Y
Published: June 2020

Dekel & Birnboim proposed that the mass-scale that separates late-type and early-type galaxies is linked to the critical halo mass $M_{\rm vir}^{\rm crit}$ for the propagation of a stable shock and showed that they could reproduce the observed bimodality scale for plausible values of the metallicity of the accreted gas Zaccr and the shock radius rs. Here, we take their analysis one step further and present a new semianalytic model that computes rs from first principles. This advancement allows us to compute $M_{\rm vir}^{\rm crit}$ individually for each halo. Separating cold-mode and hot-mode accretion has little effect on the final galaxy masses if feedback does not preferentially couple to the hot gas. We also present an improved model for stellar feedback where ${\sim }70{{\ \rm per\ cent}}$ of the wind mass is in a cold galactic fountain with a shorter reaccretion time-scale at high masses. The latter is the key mechanism that allows us to reproduce the low-mass end of the mass function of galaxies over the entire redshift range 0 < z < 2.5. Cooling must be mitigated to avoid overpredicting the number density of galaxies with stellar mass $M_{\rm stars}\gt 10^{11}\, {\rm M}_\odot$ but is important to form intermediate-mass galaxies. At $M_{\rm vir}\gt 3\times 10^{11}\, {\rm M}_\odot$, cold accretion is more important at high z, where gas is accreted from smaller solid angles, but this is not true at lower masses because high-z filaments have lower metallicities. Our predictions are consistent with the observed metallicity evolution of the intergalactic medium at 0 < z < 5.
Can magnetized turbulence set the mass scale of stars?
Authors: Guszejnov Dávid , Grudić Michael Y , Hopkins Philip F , Offner Stella S R , Faucher-Giguère Claude-André
Published: June 2020

Understanding the evolution of self-gravitating, isothermal, magnetized gas is crucial for star formation, as these physical processes have been postulated to set the initial mass function (IMF). We present a suite of isothermal magnetohydrodynamic (MHD) simulations using the gizmo code that follow the formation of individual stars in giant molecular clouds (GMCs), spanning a range of Mach numbers found in observed GMCs ($\mathcal {M} \sim 10\!-\!50$). As in past works, the mean and median stellar masses are sensitive to numerical resolution, because they are sensitive to low-mass stars that contribute a vanishing fraction of the overall stellar mass. The mass-weighted median stellar mass M50 becomes insensitive to resolution once turbulent fragmentation is well resolved. Without imposing Larson-like scaling laws, our simulations find $M_\mathrm{50} \,\, \buildrel\propto \over \sim \,\,M_\mathrm{0} \mathcal {M}^{-3} \alpha _\mathrm{turb}\, \mathrm{SFE}^{1/3}$ for GMC mass M0, sonic Mach number $\mathcal {M}$, virial parameter αturb, and star formation efficiency SFE = M⋆/M0. This fit agrees well with previous IMF results from the ramses, orion2, and sphng codes. Although M50 has no significant dependence on the magnetic field strength at the cloud scale, MHD is necessary to prevent a fragmentation cascade that results in non-convergent stellar masses. For initial conditions and SFE similar to star-forming GMCs in our Galaxy, we predict M50 to be $\gt 20 \, \mathrm{M}_{\odot }$, an order of magnitude larger than observed ($\sim 2 \, \mathrm{M}_\odot$), together with an excess of brown dwarfs. Moreover, M50 is sensitive to initial cloud properties and evolves strongly in time within a given cloud, predicting much larger IMF variations than are observationally allowed. We conclude that physics beyond MHD turbulence and gravity are necessary ingredients for the IMF.
ALMA observations of CS in NGC 1068: chemistry and excitation
Authors: Scourfield M , Viti S , García-Burillo S , Saintonge A , Combes F , Fuente A , Henkel C , Alonso-Herrero A , Harada N , Takano S , Nakajima T , Martín S , Krips M , van der Werf P P , Aalto S , Usero A , Kohno K
Published: June 2020

We present results from Atacama Large Millimeter/submillimeter Array (ALMA) observations of CS from the nearby galaxy NGC 1068 (∼14 Mpc). This Seyfert 2 barred galaxy possesses a circumnuclear disc (CND, r ∼ 200 pc) and a starburst ring (SB ring, r ∼ 1.3 kpc). These high-resolution maps (∼0.5 arcsec, ∼35 pc) allow us to analyse specific sub-regions in the galaxy and investigate differences in line intensity ratios and physical conditions, particularly those between the CND and SB ring. Local thermodynamic equilibrium (LTE) analysis of the gas is used to calculate CS densities in each sub-region, followed by the non-LTE analysis conducted using the radiative transfer code radex to fit observations and constrain gas temperature, CS column density and hydrogen density. Finally, the chemical code uclchem is used to reconstruct the gas, allowing an insight into its origin and chemical history. The density of hydrogen in the CND is found to be ≥105 cm−2, although exact values vary, reaching 106 cm−2 at the active galactic nucleus. The conditions in the two arms of the SB ring appear similar to one another, though the density found (∼104 cm−2) is lower than in the CND. The temperature in the CND increases from east to west, and is also overall greater than found in the SB ring. These modelling methods indicate the requirement for multiphase gas components in order to fit the observed emission over the galaxy. A larger number of high-resolution transitions across the SLED may allow for further constraining of the conditions, particularly in the SB ring.
Radiative kinetic simulations of steady-state relativistic plasmoid magnetic reconnection
Authors: Ortuño-Macías José , Nalewajko Krzysztof
Published: June 2020

We present the results of two-dimensional particle-in-cell (PIC) simulations of relativistic magnetic reconnection (RMR) in electron–positron plasma, including the dynamical influence of the synchrotron radiation process, and integrating the observable emission signatures. The simulations are initiated with a single Harris current layer with a central gap that triggers the RMR process. We achieve a steady-state reconnection with unrestricted outflows by means of open boundary conditions. The radiative cooling efficiency is regulated by the choice of initial plasma temperature Θ. We explore different values of Θ and of the background magnetization σ0. Throughout the simulations, plasmoids are generated in the central region of the layer, and they evolve at different rates, achieving a wide range of sizes. The gaps between plasmoids are filled by smooth relativistic outflows called minijets, whose contribution to the observed radiation is very limited due to their low-particle densities. Small-sized plasmoids are rapidly accelerated; however, they have lower contributions to the observed emission, despite stronger relativistic beaming. Large-sized plasmoids are slow but produce most of the observed synchrotron emission, with major part of their radiation produced within the central cores, the density of which is enhanced by radiative cooling. Synchrotron light curves show rapid bright flares that can be identified as originating from mergers between small/fast plasmoids and large/slow targets moving in the same direction. In the high-magnetization case, the accelerated particles form a broken power-law energy distribution with a soft tail produced by particles accelerated in the minijets.
Premature ovarian insufficiency in the XO female mouse on the C57BL/6J genetic background
Authors: Vaz B , El Mansouri F , Liu X , Taketo T
Published: June 2020

In humans, all but 1% of monosomy 45.X embryos die in utero and those who reach term suffer from congenital abnormalities and infertility termed Turner’s syndrome (TS). By contrast, XO female mice on various genetic backgrounds show much milder physical defects and normal fertility, diminishing their value as an animal model for studying the infertility of TS patients. In this article, we report that XO mice on the C57BL/6J (B6) genetic background showed early oocyte loss, infertility or subfertility and high embryonic lethality, suggesting that the effect of monosomy X in the female germline may be shared between mice and humans. First, we generated XO mice on either a mixed N2(C3H.B6) or B6 genetic background and compared the number of oocytes in neonatal ovaries; N2.XO females retained 45% of the number of oocytes in N2.XX females, whereas B6.XO females retained only 15% of that in B6.XX females. Second, while N2.XO females were as fertile as N2.XX females, both the frequency of delivery and the total number of pups delivered by B6.XO females were significantly lower than those by B6.XX females. Third, after mating with B6 males, both N2.XO and B6.XO females rarely produced XO pups carrying paternal X chromosomes, although a larger percentage of embryos was found to be XO before implantation. Furthermore, B6.XO females delivered 20% XO pups among female progeny after mating with C3H males. We conclude that the impact of monosomy X on female mouse fertility depends on the genetic background.
Exploratory Analyses of the Popularity and Efficacy of Four Behavioral Methods of Gradual Smoking Cessation
Authors: Lindson Nicola , Michie Susan , Aveyard Paul
Published: June 2020

Introduction

Around half of smokers attempt to stop by cutting-down first. Evidence suggests that this results in similar quit rates to abrupt quitting. Evidence for the effectiveness and popularity of different gradual cessation methods is sparse.

Methods

Secondary, exploratory, analyses of a randomized trial of gradual versus abrupt smoking cessation. Gradual participants (N = 342) chose between four methods of cutting-down over 2 weeks: cutting-out the easiest cigarettes first (HR-E); cutting-out the most difficult cigarettes first (HR-D); smoking on an increasing time schedule (SR); and not smoking during particular periods (SFP). Nicotine replacement therapy and behavioral support were provided before and after quit day. We used logistic and linear regression modeling to test whether the method chosen was associated with smoking reduction, quit attempts, and abstinence, while adjusting for potential confounders.

Results

Participants were on average 49 years old, smoked 20 cigarettes per day, and had a Fagerstrom Test for Cigarette Dependence score of 6. 14.9% (51/342) chose HR-E, 2.1% (7/342) HR-D, 46.2% (158/342) SFP, and 36.8% (126/342) SR. We found no evidence of adjusted or unadjusted associations between method and successful 75% reduction in cigarette consumption, reduction in percentage cigarettes per day or exhaled carbon monoxide, quit attempts, or abstinence at 4-week or 6-month follow-up.

Conclusions

Future research and practice could focus more heavily on the SR and SFP methods as these appeared notably more popular than HR. There was substantial imprecision in the efficacy data, which should be treated with caution; however, none of the gradual cessation methods showed clear evidence of being more efficacious than others.

Implications

There is evidence that people who would like to quit smoking gradually should be supported to do so. However, as this is relatively new thinking and there is large potential for variation in methods, guidance on the best way to offer support is sparse. This article is an exploratory analysis of the popularity and efficacy of various methods in an attempt to move the topic forward and inform the implementation of gradual smoking cessation methods in practice. The identified popularity of some methods over others signposts directions for future research.
Evidence for the Efficacy of an Opioid-Sparing Effect of Intravenous Acetaminophen in the Surgery Patient: A Systematic Review
Authors: Hilleman Daniel E , Malesker Mark A , Aurit Sarah J , Morrow Lee
Published: June 2020

Background

Intravenous (IV) acetaminophen is used in multimodal analgesia to reduce the amount and duration of opioid use in the postoperative setting.

Methods

A systematic review of published randomized controlled trials was conducted to define the opioid-sparing effect of IV acetaminophen in different types of surgeries. Eligible studies included prospective, randomized, double-blind trials of IV acetaminophen compared with either a placebo- or active-treatment group in adult (age ≥18 years) patients undergoing surgery. Trials had to be published in English in a peer-reviewed journal.

Results

A total of 44 treatment cohorts included in 37 studies were included in the systematic analysis. Compared with active- or placebo-control treatments, IV acetaminophen produced a statistically significant opioid-sparing effect in 14 of 44 cohorts (32%). An opioid-sparing effect was more common in placebo-controlled comparisons. Of the 28 placebo treatment comparisons, IV acetaminophen produced an opioid-sparing effect in 13 (46%). IV acetaminophen produced an opioid-sparing effect in only 6% (one out of 16) of the active-control groups. Among the 16 active-control groups, opioid consumption was significantly greater with IV acetaminophen than the active comparator in seven cohorts and not significantly different than the active comparator in eight cohorts.

Conclusions

The results of this systematic analysis demonstrate that IV acetaminophen is not effective in reducing opioid consumption compared with other adjuvant analgesic agents in the postoperative patient. In patients where other adjuvant analgesic agents are contraindicated, IV acetaminophen may be an option.
Brain and motor synchrony in children and adolescents with ASD—a fNIRS hyperscanning study
Authors: Kruppa Jana A , Reindl Vanessa , Gerloff Christian , Oberwelland Weiss Eileen , Prinz Julia , Herpertz-Dahlmann Beate , Konrad Kerstin , Schulte-Rüther Martin
Published: June 2020

Brain-to-brain synchrony has been proposed as an important mechanism underlying social interaction. While first findings indicate that it may be modulated in children with autism spectrum disorder (ASD), no study to date has investigated the influence of different interaction partners and task characteristics. Using functional near-infrared spectroscopy hyperscanning, we assessed brain-to-brain synchrony in 41 male typically developing (TD) children (8–18 years; control sample), as well as 18 children with ASD and age-matched TD children (matched sample), while performing cooperative and competitive tasks with their parents and an adult stranger. Dyads were instructed either to respond jointly in response to a target (cooperation) or to respond faster than the other player (competition). Wavelet coherence was calculated for oxy- and deoxyhemoglobin brain signals. In the control sample, a widespread enhanced coherence was observed for parent–child competition, and a more localized coherence for parent–child cooperation in the frontopolar cortex. While behaviorally, children with ASD showed a lower motor synchrony than children in the TD group, no significant group differences were observed on the neural level. In order to identify biomarkers for typical and atypical social interactions in the long run, more research is needed to investigate the neurobiological underpinnings of reduced synchrony in ASD.
Mitogenomics and the genetic differentiation of contemporaryBalaena mysticetus(Cetacea) from Svalbard
Authors: Bachmann Lutz , Cabrera Andrea A , Heide-Jørgensen Mads Peter , Shpak Olga V , Lydersen Christian , Wiig Øystein , Kovacs Kit M
Published: June 2020

Full mitochondrial genomes were assembled for 12 recently sampled animals from the Svalbard bowhead whale (Balaena mysticetus) stock via high-throughput sequencing data, facilitating analysis of the demographic history of the population for the first time. The Svalbard population has retained noticeable amounts of mitochondrial genome diversity despite extreme historical harvest levels. Haplotype and nucleotide diversities were similar to those estimated earlier for other bowhead whale populations. The reconstructed demographic history was in accordance with a boom–bust scenario, combining a slight Pleistocene population growth 25 000–35 000 years ago and a Holocene decline. Employing a mutation rate of 3.418 × 10–8 substitutions per site per year, the time to the most recent common ancestor for the mitochondrial genomes of the contemporary Svalbard bowhead whales was estimated to be 68 782 (54 353–83 216) years before the present. Based on 370 bp fragments of the D-loop region, significant genetic differentiation was detected between all extant bowhead whale populations across the circumpolar Arctic. Thus, the Svalbard bowhead whales can be regarded as a population with its own genetic legacy.
Cultivar- and Wood Area-Dependent Metabolomic Fingerprints of Grapevine Infected by Botryosphaeria Dieback
Authors: Lemaitre-Guillier Christelle , Fontaine Florence , Roullier-Gall Chloé , Harir Mourad , Magnin-Robert Maryline , Clément Christophe , Trouvelot Sophie , Gougeon Régis D. , Schmitt-Kopplin Philippe , Adrian Marielle
Published: June 2020

Botryosphaeria dieback is one of the most significant grapevine trunk diseases that affects the sustainability of the vineyards and provokes economic losses. The causal agents, Botryosphaeriaceae species, live in and colonize the wood of the perennial organs causing wood necrosis. Diseased vines show foliar symptoms, chlorosis, or apoplexy, associated to a characteristic brown stripe under the bark. According to the susceptibility of the cultivars, specific proteins such as PR-proteins and other defense-related proteins are accumulated in the brown stripe compared with the healthy woody tissues. In this study, we enhanced the characterization of the brown stripe and the healthy wood by obtaining a metabolite profiling for the three cultivars Chardonnay, Gewurztraminer, and Mourvèdre to deeper understand the interaction between the Botryosphaeria dieback pathogens and grapevine. The study confirmed a specific pattern according to the cultivar and revealed significant differences between the brown stripe and the healthy wood, especially for phytochemical and lipid compounds. This is the first time that such chemical discrimination was made and that lipids were so remarkably highlighted in the interaction of Botryosphaeriaceae species and grapevine. Their role in the disease development is discussed.
Comparison of ventriculoperitoneal shunt to lumboperitoneal shunt in the treatment of posthemorrhagic hydrocephalus
Authors: Sun Tong , You Chao , Ma Lu , Yuan Yikai , Yang Jingguo , Tian Meng , Zhou Yicheng , Guan Junwen
Published: June 2020

Background:

Ventriculoperitoneal shunt (VPS) surgery remains the most widely accepted and used option method to treat post-hemorrhagic hydrocephalus (PHH) worldwide while lumboperitoneal shunt (LPS) serves as an effectively alternative treatment. However, the outcomes of VPS and LPS in the treatment of PHH have not been compared in a prospective trial.

Methods and design:

In this monocentric, assessor-blinded, non-randomized controlled trial, 75 eligible patients with PHH for each group will be recruited to compare the outcomes of VPS cohort with that of LPS cohort. Each participant is evaluated before surgery, at the time of discharge, 3, and 6 months after surgery by experienced and practiced assessors. The primary outcome is the rate of shunt failure 6 months after shunt surgery. The secondary measure of efficacy is National Institute of Health stroke scale, together along with Glasgow coma scale, modified Rankin Scale, and Evans index at the evaluation point. A favorable outcome is defined as shunt success with an improvement of more than 1 point in the National Institute of Health stroke scale. Complication events occurring within 6 months after surgery are investigated. A serious adverse events throughout the study are recorded regarding the safety of shunts.

Discussion:

The results of this trial will provide evidence for the treatment options for patients with PHH.
Effectiveness of extracorporeal shock wave for post-stroke shoulder-hand syndrome
Authors: Wang Tian-shu , Wang Shou-feng , Song Wei-dong , Tang Zhao-chen , Zhao Yu , Lee Ken
Published: June 2020

Background:

Post-stroke shoulder-hand syndrome (PSSHS) is one of the most common sequelae in patients with stroke. Previous studies have reported that extracorporeal shock wave (EPSW) has been used to treat this condition effectively. However, its conclusions are still inconsistent. Therefore, this study will provide evidence to systematically assess the effectiveness and safety of EPSW for the treatment of PSSHS.

Methods:

We will comprehensively search relevant randomized controlled trials (RCTs) assessing the effectiveness and safety of EPSW for the treatment of PSSHS in the following databases from their start to February 1, 2020 without language and publication date limitations: Cochrane Library, MEDLINE, EMBASE, CINAHL, Web of Science, PsycINFO, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. For trials that meet all inclusion criteria, 2 researchers will independently extract the data from them and appraise study quality by Cochrane risk of bias. Any differences will be solved by discussion with the help of another researcher. All data will be performed and analyzed using RevMan 5.3 software.

Results:

We will summarize up-to-date high quality RCTs to evaluate the effectiveness and safety of EPSW for the treatment of PSSHS.

Conclusions:

This study will provide a comprehensive evidence summary to determine whether EPSW is effective and safety for the treatment of PSSHS or not.

PROSPERO registration number:

PROSPERO CRD42020175630.
Dual-task interference is related to attentional level in healthy farmers
Authors: Shin Dabi , Kang Eun Kyoung
Published: June 2020

Dual-task interference (DTI) is a decreased performance when conducting 2 tasks simultaneously, such as cognitive and motor tasks. This study aimed to identify the DTI-related factors with individually computerized interference and analyze the relative implications of decreasing DTI in healthy farmers.

It followed 3 computerized experiments:

The reaction time of correct releases (CRT) of BT1 in all tasks was measured, and the CRT ratios of DT were divided by the CRT values from CT and MT to obtain the DTI value. CRT during CT and MT was decreased compared to that during DT. The interference by CT (CRT of DT/CRT of MT × 100, CTI) was increased compared to the interference by MT (CRT of DT/CRT of CT×100, MTI). Additionally, comprehensive baseline characteristics, body composition, psycho-cognitive, and physical factors were assessed.

Of a total of 54 participants, 16 are males (67.2 ± 8.9 years) and 38 females (62.5 ± 6.6 years). CTI showed significant correlations with age (r = 0.436, P < .001), farming period (r = 0.290, P = .033), score of the Mini-Mental State Examination in the Korean version of CERAD Assessment Packet (r = −0.329, P = .015), CRT of the Go/No-Go test (r = 0.67, P < .001), score of the short physical performance battery (r = −0.304, P = .026), and time of the timed up and go test (r = 0.364, P = .007). Regression analysis showed that the CRT of the Go/No-Go test (β = 0.558, P < .001) was the most explanatory factors for CTI.

Based on the individualized DTI values quantified, interference during cognitive task was mostly related to CRT of Go/No-Go test, reflecting the attentional level. These results could suggest strategies for the active attentional training to reduce DTI and passive simplification and modification of lifestyles.
Inspection and polypectomy during both insertion and withdrawal or only during withdrawal of colonoscopy?
Authors: Wei Yaping , Shen Guofan , Yang Yutong , Jin Zheng , Hu Wei , Zhu Ying
Published: June 2020

Introduction:

Current evidence supporting additional inspection and polypectomy during insertion of colonoscopy is limited. We plan to provide a systematic review and meta-analysis to compare the yield of inspection and polypectomy during both insertion and withdrawal versus the traditional practice of inspection and polypectomy during withdrawal only.

Methods and analysis:

Randomised controlled trials evaluating inspection and polypectomy during both insertion and withdrawal versus inspection and polypectomy during withdrawal only will be searched in MEDLINE, EMBASE, Web of Science, the Cochrane Library, ClinicalTrials.gov, and Google Scholar, from database inception to 31 May 2020. Data on study design, participant characteristics, and outcomes will be extracted. Primary outcomes to be assessed are adenoma detection rate. Secondary outcomes include polyp detection rate, advanced adenoma detection rate, the mean number of adenomas per patient, polyp miss rate, the mean number of adenomas per colonoscopy, procedure duration, cecal intubation rate, procedure difficulty, patient discomfort, sedation dose, and adverse events. Study quality will be assessed using the Cochrane Risk of Bias Tool. Meta-analysis will be performed using RevMan V.5.3 statistical software. Data will be combined with random effect model. The results will be presented as a risk ratio (RR) for dichotomous data, and weighted/standard mean difference for continuous data. Publication bias will be visualized using funnel plots.

Ethics and dissemination:

This study will not use primary data, and therefore formal ethical approval is not required. The findings will be disseminated through peer-reviewed journals and committee conferences.

Protocol registration number:

INPLASY202050051.
Hand metastasis in a patient with cervical cancer
Authors: Gallardo-Alvarado Lenny , Ramos Alma Astorga , Perez-Montiel Delia , Ramirez-Morales Rebeca , Diaz Erick , Leon David Cantu-de
Published: June 2020

Introduction:

Acrometastasis is infrequent and generally indicates a wider spread of metastasis with poor prognosis. The diagnosis is challenging, as it might mimic an infectious, inflammatory, or metabolic disease. Acrometastasis are most commonly found in patients with lung, gastrointestinal, kidney, and breast cancer. Only 3 cases of cervical cancer associated with hand metastasis have been reported in the literature.

Patient concerns:

Herein, we report a 58-year-old patient with locally advanced cervical cancer and recurrence in the right thumb as presentation of widespread disseminated disease. She initially presented with adenocarcinoma of the uterine cervix and was treated with concurrent chemoradiation followed by high-dose rate brachytherapy. Six months later, she developed an insidious onset of pain and swelling in the right thumb, erythema, and edema, mimicking cellulitis.

Diagnosis:

A biopsy of the soft tissues of the thumb was performed, and the histopathology indicated metastasis of adenocarcinoma to the bone and soft tissues.

Interventions and outcomes:

The patient rejected further treatment and died of progressive disease 4 months after the diagnosis of the recurrence.

Conclusion:

Metastases in unusual sites are a diagnostic challenge, and there is no standardized treatment. Timely diagnosis and treatment can improve the prognosis of these patients and might preserve their quality of life.
Effectiveness of suprascapular nerve block for the treatment of frozen shoulder
Authors: Wang Shou-feng , Wang Tian-shu , Li Jian-an , Tang Zhao-chen , Qiao Xiao-feng
Published: June 2020

Background:

This study will appraise the effectiveness and safety of suprascapular nerve block (SNB) for the treatment of frozen shoulder (FS).

Methods:

This study will incorporate studies relevant to SNB on FS. Articles will be searched in the electronic databases (MEDLINE, EMBASE, CINAHL, Web of Science, PsycINFO, Cochrane Library, WANGFANG, and CNKI) from inception to the present. In addition, this study will also retrieve conference proceedings and reference lists of included studies. All literature source searches will not be restricted by date and language. The Cochrane Risk of Bias Tool will be utilized to evaluate the quality of retrieved trials. Data will be collected independently by 2 authors. All collected data will be analyzed by RevMan 5.3 software.

Results:

This study will synthesize the most recent published high quality trials on assessing the effectiveness and safety of SNB in treating FS.

Conclusion:

The findings of this study will provide a genuine understanding and helpful evidence to determine whether SNB is effective or not in treating FS.

Study registration number:

INPLASY202050084.
Diagnostic performance of artificial intelligence to detect genetic diseases with facial phenotypes
Authors: Qin Bosheng , Quan Qiyao , Wu Jingchao , Liang Letian , Li Dongxiao
Published: June 2020

Background:

Many genetic diseases are known to have distinctive facial phenotypes, which are highly informative to provide an opportunity for automated detection. However, the diagnostic performance of artificial intelligence to identify genetic diseases with facial phenotypes requires further investigation. The objectives of this systematic review and meta-analysis are to evaluate the diagnostic accuracy of artificial intelligence to identify the genetic diseases with face phenotypes and then find the best algorithm.

Methods:

The systematic review will be conducted in accordance with the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols” guidelines. The following electronic databases will be searched: PubMed, Web of Science, IEEE, Ovid, Cochrane Library, EMBASE and China National Knowledge Infrastructure. Two reviewers will screen and select the titles and abstracts of the studies retrieved independently during the database searches and perform full-text reviews and extract available data. The main outcome measures include diagnostic accuracy, as defined by accuracy, recall, specificity, and precision. The descriptive forest plot and summary receiver operating characteristic curves will be used to represent the performance of diagnostic tests. Subgroup analysis will be performed for different algorithms aided diagnosis tests. The quality of study characteristics and methodology will be assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 tool. Data will be synthesized by RevMan 5.3 and Meta-disc 1.4 software.

Results:

The findings of this systematic review and meta-analysis will be disseminated in a relevant peer-reviewed journal and academic presentations.

Conclusion:

To our knowledge, there have not been any systematic review or meta-analysis relating to diagnosis performance of artificial intelligence in identifying the genetic diseases with face phenotypes. The findings would provide evidence to formulate a comprehensive understanding of applications using artificial intelligence in identifying the genetic diseases with face phenotypes and add considerable value in the future of precision medicine.

OSF Registration:

DOI 10.17605/OSF.IO/P9KUH.
Simultaneous coronary thrombosis with multisite myocardial infarction and complex malignant arrhythmia
Authors: Wu Mu-li , Xu Duan-Min , Chen Chang , Chen Ye-qun , Sun Yi-Fan , Hu Chuang-jia
Published: June 2020

Introduction:

Acute myocardial infarction with simultaneous coronary thrombosis has been rarely reported. This combination induces various arrhythmias and is a high-risk factor for cardiogenic shock.

Patient concerns:

A 65-year-old man presented with sweating and a 3-h abrupt persistent back pain that radiated to the anterior.

Diagnosis:

Multisite myocardial infarction, coronary thrombosis with and complex malignant arrhythmia

Interventions:

Prompt intervention includes cardiac pacing, percutaneous coronary intervention (PCI), thrombus aspiration and intra-aortic balloon pump (IABP).

Outcomes:

The patient was successfully rescued after PCI and thrombus aspiration.

Conclusions:

Recognition of dynamic electrocardiographic changes enhances our understanding of the pathogenesis of myocardial infarction.
Predicting outcome of repair of medial meniscus posterior root tear with early osteoarthritis using bone single-photon emission computed tomography/computed tomography
Authors: Whi Wonseok , Park Jae-Young , Choi Hongyoon , Paeng Jin Chul , Cheon Gi Jeong , Kang Keon Wook , Lee Dong Soo , Han Hyuk-Soo
Published: June 2020

Repair of medial meniscus posterior root tear (MMPRT) is considered as an effective early intervention strategy for osteoarthritis. We aimed at evaluating whether or not single-photon emission computed tomography/computed tomography (SPECT/CT) could predict the treatment outcome.

Eleven patients with MMPRT who underwent preoperative SPECT/CT were retrospectively enrolled. Clinical symptoms were evaluated based on the knee injury and osteoarthritis outcome score (KOOS) and visual analogue scale (VAS) for pain. The uptake pattern of the medial tibial plateau (MTP) on SPECT/CT was visually assessed. Additionally, the maximum lesion-to-cortical counts ratio (LCRmax) for the anterior and posterior aspects of MTP and anterior-posterior MTP ratio (APR) were quantitatively assessed. Spearman correlation analyses were performed between the change in clinical symptom scores and preoperative SPECT/CT patterns.

All patients showed increased radiotracer uptake in MTP. Among them, 8 (73%) showed dominant uptake in the anterior aspect of MTP. The rest 3 (27%) showed posterior-dominant uptake. Patients with anterior-dominant patterns tended to show better outcomes in terms of the postoperative KOOS score (P = .07). Anterior MTP LCRmax showed a negative correlation with the change in VAS (ρ = −0.664, P < .03). APR showed a correlation with the change in the KOOS score (ρ = 0.655, P < .03).

Patients with MMPRT with relatively higher uptake in the anterior aspect of MTP could have better clinical outcomes after the repair. The preoperative SPECT/CT pattern may have a predictive value in selecting patients with good postoperative outcomes.
The diagnosis of intramural esophageal squamous cell carcinoma without mucosal invasion using endoscopic ultrasound-guided fine needle aspiration biopsy
Authors: Pan Hanghai , Zhou XinXin , Zhao Fei , Lou Guochun
Published: June 2020

Rationale:

Intramural esophageal squamous cell carcinoma (ESCC) without mucosal invasion is extremely rare. Endoscopic mucosal biopsy results are often negative, making diagnosis difficult. In these cases, endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) biopsy is a useful diagnostic method.

Patient concerns:

A 78-year-old female was admitted to hospital due to dysphagia, and gastroscopy showed a concentric narrowing of the esophageal lumen with a smooth and undamaged esophageal mucosa.

Diagnoses:

Endoscopic ultrasound (EUS) revealed that the esophageal mucosa was thickened with a low echo, and the layers of the esophageal wall could not be clearly distinguished. Cytologic and pathologic diagnoses were obtained through EUS-FNA, which suggested ESCC.

Interventions:

According to the pathologic diagnosis obtained by EUS-FNA, surgery or radiotherapy were recommended for this patient. Eventually, this patient elected to seek treatment at another medical institution.

Outcomes:

This type of disease cannot be diagnosed according to gastroscopic biopsy alone, and the diagnosis was eventually confirmed through EUS-FNA.

Lessons:

When an imaging examination suggests a possible malignant lesion of the oesophagus, EUS-FNA may be considered if the surface mucosa contains no endoscopic damage. EUS-FNA has high diagnostic value with high sensitivity, minimal invasiveness, and high safety.
BRAIN MR SPECTROSCOPIC FINDINGS IN THREE CONSECUTIVE COVID-19 PATIENTS: PRELIMINARY OBSERVATIONS
Authors: Rapalino Otto , Weerasekera Akila , Moum Sarah J. , Eikermann-Haerter Katharina , Edlow Brian L. , Fischer David , Mukerji Shibani , Schaefer Pamela W. , Gonzalez R. Gilberto , Lev Michael , Ratai Eva-Maria
Published: June 2020

Brain magnetic resonance spectroscopic imaging (MRSI) was performed in three consecutive COVID-19 patients, as part of a pilot investigation of the pathophysiological processes underlying the brain involvement by the SARS-CoV-2 infection. These included one with necrotizing leukoencephalopathy, one after recent PEA cardiac arrest without leukoencephalopathy, and one without frank encephalopathy or recent severe hypoxic episode. The MRSI findings were compared to those of two patients with white matter pathology not SARS-CoV2 infection related, and a control patient without clinical encephalopathy. The N-acetylaspartate reduction, choline elevation, and glutamate/glutamine elevation found in the COVID necrotizing leukoencephalopathy patient and, to a lesser degree, the COVID post-cardiac arrest patient, follow a similar pattern as seen with the delayed post-hypoxic leukoencephalopathy patient. Lactate elevation was most pronounced in the patient with COVID necrotizing leukoencephalopathy.
Amplitude modulations of sensory responses, and deviations from Weber’s Law in pulsatile evidence accumulation
Authors: Koay Sue Ann , Thiberge Stephan Y. , Brody Carlos D. , Tank David W.
Published: June 2020

How do animals make behavioral decisions based on noisy sensory signals, which are moreover a tiny fraction of ongoing activity in the brain? Some theories suggest that sensory responses should be accumulated through time to reduce noise. Others suggest that feedback-based gain control of sensory responses allow small signals to be selectively amplified to drive behavior. We recorded from neuronal populations across posterior cortex as mice performed a decision-making task based on accumulating randomly timed pulses of visual evidence. Here we focus on a subset of neurons, with putative sensory responses that were time-locked to each pulse. These neurons exhibited a variety of amplitude (gain-like) modulations, notably by choice and accumulated evidence. These neural data inspired a hypothetical accumulation circuit with a multiplicative feedback-loop architecture, which parsimoniously explains deviations in perceptual discrimination from Weber-Fechner Law. Our neural observations thus led to a model that synthesizes both accumulation and feedback hypotheses.
Performance in even a simple perceptual task depends on mouse secondary visual areas
Authors: Goldbach Hannah C , Akitake Bradley , Leedy Caitlin E , Histed Mark H
Published: June 2020

Primary visual cortex (V1) in the mouse projects to numerous brain areas, including several secondary visual areas, frontal cortex, and basal ganglia. While it has been demonstrated that optogenetic silencing of V1 strongly impairs visually-guided behavior, it is not known which downstream areas are required for visual behaviors. Here we trained mice to perform a contrast-increment change detection task, for which substantial stimulus information is present in V1. Optogenetic silencing of visual responses in secondary visual areas revealed that their activity is required for even this simple visual task.In vivoelectrophysiology showed that, although inhibiting secondary visual areas could produce some feedback effects in V1, the principal effect was profound suppression at the location of the optogenetic light. The results show that pathways through secondary visual areas are necessary for even simple visual behaviors.
Spatiotemporal coding in the macaque supplementary eye fields: landmark influence in the target-to-gaze transformation
Authors: Bharmauria Vishal , Sajad Amirsaman , Yan Xiaogang , Wang Hongying , Douglas Crawford John
Published: June 2020

Eye-centered (egocentric) and landmark-centered (allocentric) visual signals influence spatial cognition, navigation and goal-directed action, but the neural mechanisms that integrate these signals for motor control are poorly understood. A likely candidate for ego / allocentric integration in the gaze control system is the supplementary eye fields (SEF), a mediofrontal structure with high-level ‘executive’ functions, spatially tuned visual / motor response fields, and reciprocal projections with the frontal eye fields (FEF). To test this hypothesis, we trained two head-unrestrained animals to saccade toward a remembered visual target in the presence of a visual landmark that shifted during the delay, causing gaze end points to shift partially in the same direction. 256 SEF neurons were recorded, including 68 with spatially tuned response fields. Model fits to the latter established that, like the FEF and superior colliculus, spatially tuned SEF responses primarily showed an egocentric (eye-centered) target-to-gaze position transformation. However, the landmark shift influenced this default egocentric transformation: during the delay, motor neurons (with no visual response) showed a transient but unintegrated shift (i.e., not correlated with the target-to-gaze transformation), whereas during the saccade-related burst visuomotor neurons showed an integrated shift (i.e., correlated with the target-to-gaze transformation). This differed from our simultaneous FEF recordings (Bharmauria et al., 2020), which showed a transient shift in visuomotor neurons, followed by an integrated response in all motor responses. Based on these findings and past literature, we propose that prefrontal cortex incorporates landmark-centered information into a distributed, eye-centered target-to-gaze transformation through a reciprocal prefrontal circuit.
Sex differences in the effect of acute fasting on excitatory and inhibitory synapses onto ventral tegmental area dopamine neurons
Authors: Godfrey Nathan , Borgland Stephanie L.
Published: June 2020

Dopamine neurons in the ventral tegmental area (VTA) are important for energizing goal directed behaviour towards food and are sensitive to changes in metabolic states. Fasting increases the incentive motivation for food, mobilization of energy stores and have sex-dependent effects. However, it is unknown how acute fasting alters excitatory or inhibitory synaptic transmission onto VTA dopamine neurons. An acute 16h overnight fast induced increased food seeking behaviour that was more predominant in male mice. Fasting increased miniature excitatory postsynaptic current (mEPSC) frequency and amplitude in male, but not female mice. This effect was not due to altered release probability as there was no change in the paired pulse ratio, nor was it due to an altered postsynaptic response as there was no change in the AMPAR/NMDA ratio or response to glutamate uncaging. However, this effect was consistent with an increase in the number of release sites. In addition, depolarization-induced-suppression of excitation (DSE), a measure of short-term endocannabinoid-mediated plasticity, was enhanced in female but not male fasted mice. There were no fasting-induced changes at inhibitory synapses onto dopamine neurons of male or female mice. Taken together, these results demonstrate that fasting influences excitatory synapses differentially in male and female mice, but preserves inhibitory synapses onto dopamine neurons, indicating that the mesolimbic circuit of male and female mice respond differently to acute energy deprivation.

Key Points

Fasting can increase motivation for food and can energize reward-seeking.

Ventral tegmental area (VTA) dopamine neurons respond to motivationally relevant information and fasting can influence mesolimbic dopamine concentration.

An acute overnight fast differentially alters food approach behaviours and excitatory synaptic transmission onto VTA dopamine neurons of male or female mice.

While inhibitory synapses onto VTA dopamine neurons are not altered by fasting in male or female mice, male mice had strengthened excitatory synapses whereas female mice had increased endocannabinoid-mediated short term plasticity at excitatory synapses.

These results help us understand how fasting differentially influences excitatory synaptic transmission onto dopamine neurons and may inform different strategies for fasting-induced food seeking by male and female mice.
Age-related losses in cardiac autonomic activity during a daytime nap
Authors: Chen Pin-Chun , Sattari Negin , Whitehurst Lauren N. , Mednick Sara C.
Published: June 2020

In healthy, young individuals, a reduction in cardiovascular output and a shift from sympathetic to parasympathetic (vagal) dominance is observed from wake into stages of nocturnal and daytime sleep. This cardiac autonomic profile, measured by heart rate variability (HRV), has been associated with significant benefits for cardiovascular health. Aging is associated with decreased nighttime sleep quality and lower parasympathetic activity during both sleep and resting. However, it is not known whether age-related dampening of HRV extends to daytime sleep, diminishing the cardiovascular benefits of naps in the elderly. Here, we investigated this question by comparing the autonomic activity profile between young and older healthy adults during a daytime nap and a similar period of wakefulness (quiet wake; QW). For each condition, from the electrocardiogram (ECG), we obtained beat-to-beat HRV intervals (RR), root mean square of successive differences between adjacent heart-beat-intervals (RMSSD), high frequency (HF), low frequency (LF) power and total power (TP), HF normalized units (HFnu), and the LF/HF ratio. As previously reported, young subjects showed a parasympathetic dominance during NREM, compared with REM, pre-nap rest, and WASO. On the other hand, older, compared to younger, adults showed significantly lower vagally-mediated HRV (measured by RMSSD, HF, HFnu) during NREM. Interestingly, however, no age-related differences were detected during pre-nap rest or QW. Altogether, our findings suggest a sleep-specific reduction in parasympathetic modulation that is unique to NREM sleep in older adults.

Impact Statement

Sleep is naturally modulated by the autonomic nervous system (ANS), with greater dominance of parasympathetic over sympathetic activity during non-rapid-eye-movement (NREM) sleep. As such, sleep has been termed a “cardiovascular holiday” and has been associated with positive health outcomes. Aging, however, is linked to decreases in cardiac autonomic activity and sympathovagal imbalance. While the impact of aging on ANS activity during nocturnal sleep has received some attention, the cardiac profiles during a daytime nap, to our knowledge, have not yet been studied under the context of aging. Herein, young adults demonstrated increased parasympathetic activity during deep sleep. Older adults, however, showed less parasympathetic modulation during NREM sleep, suggesting loss of the cardiovascular holiday. Importantly, no age-related declines in parasympathetic activity were detected during wake, suggesting a sleep-specific reduction in parasympathetic modulation that is unique to NREM sleep in older adults.