bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrative analysis of miRNA and mRNA profiles reveals that gga-miR-106-5p inhibits adipogenesis by targeting the KLF15 gene in chickens
Authors: Tian Weihua , Hao Xin , Nie Ruixue , Ling Yao , Zhang Bo , Zhang Hao , Wu Changxin
Published: July 2022

Background

Excessive abdominal fat deposition in commercial broilers presents an obstacle to profitable meat quality, feed utilization, and reproduction. Abdominal fat deposition depends on the proliferation of preadipocytes and their maturation into adipocytes, which involves a cascade of regulatory molecules. Accumulating evidence has shown that microRNAs (miRNAs) serve as post-transcriptional regulators of adipogenic differentiation in mammals. However, the miRNA-mediated molecular mechanisms underlying abdominal fat deposition in chickens are still poorly understood. This study aimed to investigate the biological functions and regulatory mechanism of miRNAs in chicken abdominal adipogenesis.

Results

We established a chicken model of abdominal adipocyte differentiation and analyzed miRNA and mRNA expression in abdominal adipocytes at different stages of differentiation (0, 12, 48, 72, and 120 h). A total of 217 differentially expressed miRNAs (DE-miRNAs) and 3520 differentially expressed genes were identified. Target prediction of DE-miRNAs and functional enrichment analysis revealed that the differentially expressed targets were significantly enriched in lipid metabolism-related signaling pathways, including the PPAR signaling and MAPK signaling pathways. A candidate miRNA, gga-miR-106-5p, exhibited decreased expression during the proliferation and differentiation of abdominal preadipocytes and was downregulated in the abdominal adipose tissues of fat chickens compared to that of lean chickens. gga-miR-106-5p was found to inhibit the proliferation and adipogenic differentiation of chicken abdominal preadipocytes. A dual-luciferase reporter assay suggested that the KLF15 gene, which encodes a transcriptional factor, is a direct target of gga-miR-106-5p. gga-miR-106-5p suppressed the post-transcriptional activity of KLF15, which is an activator of abdominal preadipocyte proliferation and differentiation, as determined with gain- and loss-of-function experiments.

Conclusions

gga-miR-106-5p functions as an inhibitor of abdominal adipogenesis by targeting the KLF15 gene in chickens. These findings not only improve our understanding of the specific functions of miRNAs in avian adipogenesis but also provide potential targets for the genetic improvement of excessive abdominal fat deposition in poultry.
Application of bioactive glasses in various dental fields
Authors: Jafari Nazanin , Habashi Mina Seyed , Hashemi Alireza , Shirazi Reza , Tanideh Nader , Tamadon Amin
Published: July 2022

Bioactive glasses are a group of bioceramic materials that have extensive clinical applications. Their properties such as high biocompatibility, antimicrobial features, and bioactivity in the internal environment of the body have made them useful biomaterials in various fields of medicine and dentistry. There is a great variation in the main composition of these glasses and some of them whose medical usage has been approved by the US Food and Drug Administration (FDA) are called Bioglass. Bioactive glasses have appropriate biocompatibility with the body and they are similar to bone hydroxyapatite in terms of calcium and phosphate contents. Bioactive glasses are applied in different branches of dentistry like periodontics, orthodontics, endodontics, oral and maxillofacial surgery, esthetic and restorative dentistry. Also, some dental and oral care products have bioactive glasses in their compositions. Bioactive glasses have been used as dental implants in the human body in order to repair and replace damaged bones. Other applications of bioactive glasses in dentistry include their usage in periodontal disease, root canal treatments, maxillofacial surgeries, dental restorations, air abrasions, dental adhesives, enamel remineralization, and dentin hypersensitivity. Since the use of bioactive glasses in dentistry is widespread, there is a need to find methods and extensive resources to supply the required bioactive glasses. Various techniques have been identified for the production of bioactive glasses, and marine sponges have recently been considered as a rich source of it. Marine sponges are widely available and many species have been identified around the world, including the Persian Gulf. Marine sponges, as the simplest group of animals, produce different bioactive compounds that are used in a wide range of medical sciences. Numerous studies have shown the anti-tumor, anti-viral, anti-inflammatory, and antibiotic effects of these compounds. Furthermore, some species of marine sponges due to the mineral contents of their structural skeletons, which are made of biosilica, have been used for extracting bioactive glasses.
Short-term perfluorocarbon liquid tamponade in choroidal melanoma endoresection
Authors: Hamza Hany S. , Elnahry Ayman G.
Published: July 2022

Purpose

To report the use of short-term perfluorocarbon liquid (ST-PFCL) tamponade following choroidal melanoma endoresection.

Methods

Patients with medium to large choroidal melanomas not amenable to primary Ruthenium-106 brachytherapy underwent choroidal melanoma endoresection following gamma knife radiosurgery. During surgery, a complete vitrectomy was performed followed by PFCL injection, then a retinectomy with endoresection of the melanoma and underlying choroid was done. Complete PFCL filling was then achieved, and laser barrage surrounding the retinectomy was done. A Ruthenium-106 plaque was then inserted. Postoperatively, supine positioning was maintained for three days followed by plaque and PFCL removal with silicone oil injection. Several months later, silicone oil was removed.

Results

Four eyes of 4 patients underwent endoresection with ST-PFCL tamponade. Mean height of tumor was 8.6 ± 0.85 mm, while mean maximal basal diameter was 11.5 ± 1.1 mm. Mean preoperative logMAR best corrected visual acuity (BCVA) was 1.76 ± 0.18. All patients underwent preoperative gamma knife radiosurgery and postoperative brachytherapy. There were no major intraoperative or postoperative complications. All patients underwent silicone oil injection with PFCL/plaque removal after 3 days, while silicone oil was removed after 4 ± 1.2 months. Mean postoperative logMAR BCVA 3 months following oil removal was 0.89 ± 0.22 (p = 0.02). Mean follow-up duration was 17 ± 2.8 months. No patient developed local tumor recurrence, distant metastases, or vitreoretinal complications by final visit.

Conclusion

ST-PFCL tamponade may reduce the risk of intraoperative and postoperative complications associated with choroidal melanoma endoresection.
Screening of Beauveria bassiana (Bals.) (Hypocreales: Cordycipitaceae) strains against Megalurothrips usitatus (Bagnall) (Thysanoptera: Thripidae) and conditions for large-scale production
Authors: Camara Ibrahima , Cao Kaili , Sangbaramou Rouguiatou , Wu Peipei , Shi Wangpeng , Tan Shuqian
Published: July 2022

Background

Beauveria bassiana (Bals.) (Hypocreales: Cordycipitaceae) is an entomopathogenic fungus that has potential as a biological control agent against many insect pests. This study was conducted to optimize the conditions for large-scale production on rice of B. bassiana and evaluate its virulence against the bean flower thrips Megalurothrips usitatus (Bagnall) (Thysanoptera: Thripidae).

Results

The optimal substrate quantity for conidia production was 200 g of rice per container (2.1 l), with substrate having a 52% moisture content, being supplemented with 2% cooking oil. In stage production of a batch, 150 ml of conidia suspension (at 24.33 × 107 spores/ml) was incubated for 10 days in SDA liquid medium amended with 4% glucose and 1.5% yeast extract. The SDA medium was then used to inoculate one container of the rice substrate. The optimum ratio of conidial suspension to substrate (v/v) was 20–25%. Virulence of the spore powder harvested from the rice substrate was same as that of produced on the SDA solid media against thrips. The level of control from an application of spore powder of the thrips M. usitatus was similar to that from chemical the pesticide spinetoram when applied in a cowpea (Vigna sinensis Endl) field.

Conclusions

The optimized rice substrate system can be used for a large-scale production of B. bassiana spores, which can be used for field control of thrips.
Expanding access to medications for opioid use disorder in primary care clinics: an evaluation of common implementation strategies and outcomes
Authors: Cheng Hannah , McGovern Mark P. , Garneau Hélène Chokron , Hurley Brian , Fisher Tammy , Copeland Meaghan , Almirall Daniel
Published: July 2022

Background

To combat the opioid epidemic in the USA, unprecedented federal funding has been directed to states and territories to expand access to prevention, overdose rescue, and medications for opioid use disorder (MOUD). Similar to other states, California rapidly allocated these funds to increase reach and adoption of MOUD in safety-net, primary care settings such as Federally Qualified Health Centers. Typical of current real-world implementation endeavors, a package of four implementation strategies was offered to all clinics. The present study examines (i) the pre-post effect of the package of strategies, (ii) whether/how this effect differed between new (start-up) versus more established (scale-up) MOUD practices, and (iii) the effect of clinic engagement with each of the four implementation strategies.

Methods

Forty-one primary care clinics were offered access to four implementation strategies: (1) Enhanced Monitoring and Feedback, (2) Learning Collaboratives, (3) External Facilitation, and (4) Didactic Webinars. Using linear mixed effects models, RE-AIM guided outcomes of reach, adoption, and implementation quality were assessed at baseline and at 9 months follow-up.

Results

Of the 41 clinics, 25 (61%) were at MOUD start-up and 16 (39%) were at scale-up phases. Pre-post difference was observed for the primary outcome of percent of patient prescribed MOUD (reach) (βtime = 3.99; 0.73 to 7.26; p = 0.02). The largest magnitude of change occurred in implementation quality (ES = 0.68; 95% CI = 0.66 to 0.70). Baseline MOUD capability moderated the change in reach (start-ups 22.60%, 95% CI = 16.05 to 29.15; scale-ups −4.63%, 95% CI = −7.87 to −1.38). Improvement in adoption and implementation quality were moderately associated with early prescriber engagement in Learning Collaboratives (adoption: ES = 0.61; 95% CI = 0.25 to 0.96; implementation quality: ES = 0.55; 95% CI = 0.41 to 0.69). Improvement in adoption was also associated with early prescriber engagement in Didactic Webinars (adoption: ES = 0.61; 95% CI = 0.20 to 1.05).

Conclusions

Rather than providing an all-clinics-get-all-components package of implementation strategies, these data suggest that it may be more efficient and effective to tailor the provision of implementation strategies based on the needs of clinic. Future implementation endeavors could benefit from (i) greater precision in the provision of implementation strategies based on contextual determinants, and (ii) the inclusion of strategies targeting engagement.
Kyoo, This Word Sounds Weird: A Case Study of a Cajun English Interjection
Authors: Vidrine Lauren , Shport Irina A.
Published: July 2022

The interjection kyoo/kaw is used in the English and French of Cajun heritage speakers in Louisiana to express surprise and has not been previously documented. Anecdotally, Cajuns and non-Cajuns alike comment that it sounds “weird,” as if the word is “not English.” A survey confirms that the interjection is perceived as atypical sounding when compared to mainstream English words, even more so for the palatalized pronunciation variant (kyoo) than the nonpalatalized variant (kaw). The authors hypothesize that this perception could stem from acoustic characteristics of the interjection consistent with linguistic identity markers in Cajun speakers, attributable to Cajun French influence or to the Cajun English vernacular. Acoustic analyses show that the interjection-initial/k/is not unaspirated, its vowel is not nasalized, and it has spectral quality similar to/O/in mainstream English words. These results suggest the perception of anomalous sounds in this interjection may not be attributed to acoustic characteristics indicative of French influence. An alternative explanation to the acoustic-phonetic characteristics of kyoo/kaw lies in social representations of Cajun English in a historically bilingual and multidialectal community, where perceived oddness of a nonstandard linguistic expression can be easily attributed to the influence of another language.
Vodou, the Arts, and (Re)Presenting the Divine
Authors: Daniels Kyrah Malika
Published: July 2022

Few conversations with the renowned Haitian novelist Edwidge Danticat have delved into the subject of religion in Haiti and the representations of Vodou in her fiction and nonfiction writing. This interview with Danticat explores her religious upbringing, Vodou and interfaith dialogue, and representations of Haitian religion in the media and in the world. Other topics discussed include Haitian sacred space and the environment, Vodou as a matriarchal religion, and divine archetypes present in her body of writings. Drawing from an Africana religion framework, the questions posed here consider the religious import of Danticat’s literary works as “sacred texts” of Haiti and the Haitian dyaspora.
Consort of the Spirits
Authors: McAllister Nia
Published: July 2022

Drawing inspiration from the 1982 novel, Sassafrass, Cypress & Indigo by Ntozake Shange, the poem “Consort of the Spirits” celebrates the legacy of Black womanhood, ancestry, and resilience. The opening lines of Shange’s novel read: “Where there is a woman there is magic.” This phrase serves as the entry point for framing womanhood, specifically Black womanhood, as something extraordinary. In tribute, “Consort of the Spirits” guides readers on a journey through time and memory, depicting the tangible yet magical ways in which lineages of Black women have carried tools for their survival, protected their shared histories, and guided their descendants on a path toward a more liberated future.
Sisterhood Birthed through Colonialism
Authors: Wright-Mair Raquel , Castillo-Montoya Milagros
Published: July 2022

It is already known that one of the ways in which colonialism operates and exerts harm is by dehumanizing Black, Indigenous, and other racially minoritized populations. Less attention has been paid, however, to the ways in which this dehumanization erodes relations among those colonized. Colonial logics designed to separate and alienate the colonized from each other have been internalized for centuries, preventing communities and individuals from recognizing how they connect. In this piece, the authors draw on their experiences as racially minoritized women in the U.S. academy to reflect on how this colonial legacy has shaped not only their identities but also their identifications—how and with whom they identify. The authors demonstrate what they refer to as a love letter approach that enables them to foster connection, healing, and transformation through dialogue. Most importantly, they highlight the radical potential of finding and articulating love for one another as a form of resisting the very colonial logics that would keep them apart. They conclude the piece with guidance on how to use this approach to connect individuals, communities, and organizations.
Black Berries
Authors: Cross Davis Teri Ellen
Published: July 2022

Often the narrative on dark skin in America has been dominated by Eurocentric standards of beauty. White supremacy dictated dark skin to be unattractive and lesser than light skin. This poem explores the rich beauty of darkness in the natural world, from fruit in America to fruit in Ireland, unpacking and giving new energy to the old phrase “the blacker the berry, the sweeter the juice.” By exploring the journey from wonderment to acceptance to love, the work is a refutation of lighter skin being the only pathway to beauty, not just in America, but globally.
Effects of pulmonary rehabilitation therapy combined with conventional drugs on BODE and pulmonary function indexes in elderly patients with interstitial pneumonia
Authors: Zhang Zhen , Tian Yumei , Yang Jing
Published: July 2022

Objectives: To investigate the effect of pulmonary rehabilitation therapy combined with conventional drugs on BODE and pulmonary function (PFT) indexes in elderly patients with interstitial pneumonia.

Methods: Records of 89 elderly patients with interstitial pneumonia treated in the First Affiliated Hospital of Hunan Medical College from April 2020 to April 2021 were retrospectively selected. Of them, 41 patients received conventional drug treatment (Group-I) and 48 patients received pulmonary rehabilitation treatment and conventional drug treatment (Group-II). The clinical efficacy of therapy, BODE and PFT indexes of the two groups were compared.

Results: The total efficacy of patients in the Group-II (93.75%) was significantly higher than that of Group-I (75.61%) (P<0.05). After the treatment, the BODE index score of Group-II was lower than that of Group-I, and the forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) and peak expiratory flow rate (PEF) were higher than those of Group-I (P<0.001).

Conclusion: Combination of pulmonary rehabilitation therapy and conventional drugs can further improve the curative effect of the treatment and help to improve BODE and PFT indexes in patients with senile interstitial pneumonia.

doi: https://doi.org/10.12669/pjms.38.6.5748

How to cite this:Zhang Z, Tian Y, Yang J. Effects of pulmonary rehabilitation therapy combined with conventional drugs on BODE and pulmonary function indexes in elderly patients with interstitial pneumonia. Pak J Med Sci. 2022;38(6):1703-1707.  doi: https://doi.org/10.12669/pjms.38.6.5748

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Ανάπτυξη στοχαστικών αλγορίθμων και μοντέλων μηχανικής μάθησης για την εξέλιξη πληθυσμών
Authors: Καλαματιανός-Βουρόβ Ρωμανός
Published: July 2022

Στην παρούσα διατριβή γίνεται ανάπτυξη στοχαστικών αλγορίθμων και μοντέλων μηχανικής μάθησης για την πρόβλεψη εξέλιξης πληθυσμών και ειδικότερα για την εξέλιξη του πληθυσμού του δάκου της ελιάς. Ο δάκος της ελιάς είναι ένα παρασιτικό έντομο που εξαρτάται από τον καρπό της ελιάς για την διαιώνιση του είδους του, με αποτέλεσμα να προκαλεί μεγάλες ζημιές, αν ο πληθυσμός του μείνει ανεξέλεγκτος, στην παραγωγή προϊόντων με βάση τον καρπό της ελιάς, όπως ελαιόλαδο και επιτραπέζιες ελιές. Η παρουσία του εντόμου έχει καταγραφεί σε όλες τις ελαιοπαραγωγικές χώρες και λόγω της εξάρτησης του από τις κλιματικές συνθήκες (θερμοκρασία, υγρασία) ο συνολικός αριθμός γενεών που προκύπτουν ποικίλλει από περιοχή σε περιοχή. Σε αυτό το πλαίσιο, ως προς τους στοχαστικούς αλγορίθμους, αρχικά παρουσιάζεται το λογισμικό προσομοίωσης της χρονικής και χωρικής εξέλιξης του πληθυσμού του δάκου βάσει πραγματικών μετρήσεων στο πεδίο. Στην συνέχεια, περιγράφεται η ανάπτυξη και σύγκριση τριών μοντέλων διασποράς του δάκου με βάση την καρποφορία του ελαιώνα και τέλος, μελετάτε η επιρροή της παρουσίας μικροκλιμάτων στην εξέλιξη του πληθυσμού του δάκου μέσω προσομοίωσης, με χρήση του προαναφερθέντος λογισμικού, και πως, υπό αυτό το πρίσμα, επηρεάζεται η εξέλιξη του πληθυσμού δάκου με την εφαρμογή των συνήθων πρακτικών ελέγχου του πληθυσμού του. Συνεχίζοντας, ως προς την χρήση μεθόδων μηχανικής μάθησης, αρχικά, μελετάται η χρήση των περιβαλλοντολογικών συνθηκών για την πρόβλεψη της επόμενης μέτρησης δακοπαγίδας, δεδομένης της γνώσης της προηγούμενης μέτρησης και συγκρίνεται η απόδοση τεσσάρων χαρακτηριστικών διανυσμάτων με χρήση διαφόρων αλγορίθμων μηχανικής μάθησης. Στην συνέχεια, παρουσιάζεται η ανάπτυξη μοντέλου για την αυτόματη αναγνώριση του δάκου, και κατά συνέπεια αυτόματης καταμέτρησης, σε εικόνες του περιεχομένου της παγίδας McPhail που χρησιμοποιείται συνήθως ως μέθοδος ελέγχου και δείκτης έξαρσης του πληθυσμού του δάκου. Τέλος, μελετάται η χρήση μεθόδων μηχανικής μάθησης για την αναγνώριση μικροκλιμάτων, γεγονός που θα βοηθούσε στην πρόβλεψη εστίων προσβολής του ελαιώνα από τον δάκο ανάλογα την εποχή του χρόνου και τα κλιματολογικά χαρακτηριστικά του κάθε μικροκλίματος. Τέλος, εξάγονται τα συμπεράσματα για την απόδοση των προαναφερθέντων πειραμάτων και πιθανά σημεία που θα μπορούσε να εστιάσει τυχόν μελλοντική έρευνα.
Étude des mutations sociospatiales, système financier et marché immobilier en Grèce
Authors: Πατατούκα Ελένη
Published: July 2022

Η παρούσα διατριβή εξετάζει τις κοινωνικοχωρικές μεταλλαγές που προκαλούνται από τις τάσεις χρηματιστικοποίησης του ελληνικού στεγαστικού συστήματος τις τελευταίες δύο δεκαετίες. Πώς προσαρμόζονται οι παγκόσμιες διαδικασίες χρηματιστικοποίησης στο τοπικό πλαίσιο προκειμένου να δημιουργηθεί μια ελληνική εκδοχή της χρηματιστικοποίησης; Στόχος της διατριβής είναι να ρίξει φως στο μετασχηματισμό μιας αυτοχρηματοδοτούμενης οικονομίας που βασίζεται σε οικογενειακά δίκτυα στην αγορά στεγαστικών δανείων. Η υπόθεση είναι ότι αυτές οι αλλαγές στον τομέα της χρηματοδότησης του οικιστικού αστικού ιστού, ή διαφορετικά η ανάδειξη του χρηματοπιστωτικού συστήματος ως «νέου παράγοντα» στα δίκτυα παραγωγής κατοικίας, συνδέονται με την επισφάλεια της κατοικίας και τις νέες κοινωνικοχωρικές γεωγραφίες. Κατά τις μεταπολεμικές δεκαετίες, η Αθήνα, μια μεσογειακή πόλη και, ταυτόχρονα, ένα νοτιοευρωπαϊκό περιφερειακό αστικό κέντρο, χαρακτηρίζεται από έντονη κοινωνική κινητικότητα, όταν τα δίκτυα παραγωγής κατοικιών λειτουργούσαν ως «κοινωνικός ανελκυστήρας». Από τις αρχές της δεκαετίας του 1990, η Αθήνα αντιμετωπίζει τόσο νέες προκλήσεις όσο και την επιμονή των προϋπάρχουσων δομών. Είναι η πρώτη συγκυρία μίας κρίσιμης επέκτασης της στεγαστικής πίστης στην Ελλάδα, όταν οι τιμές των κατοικιών έχουν αυξηθεί σημαντικά. Η ποσοτική και ποιοτική ανάλυση, η μελέτη περίπτωσης και οι ημιδομημένες συνεντεύξεις αναδεικνύουν νέους εμπλεκόμενους, όπως και δράσεις, αναπαραστάσεις, πρακτικές καθώς και τάσεις χρηματοπιστωτικού αποκλεισμού. Η μελέτη αυτή αναδεικνύει τη σημασία της γεωγραφίας ή/και της πολεοδομίας, καθώς και τον σημαντικό ρόλο των οικογενειακών δικτύων, της κλίμακας της γειτονιάς και της καθημερινής ζωής στην ανάλυση του χρηματοπιστωτικού συστήματος, όπως και των διασυνδέσεων του χρηματοπιστωτικού συστήματος με την άτυπη οικονομία.
Ο Διαφωτιστής Rousseau και ο Primo De Rivera: η volonté générale στην υπηρεσία του φασισμού;
Authors: Ζαχαράκης Μύρων
Published: July 2022

Στο παρόν άρθρο, θα εξετάσουμε τις απόψεις του Γάλλου διανοητή και εκπροσώπου του Διαφωτισμού, Jean-Jacques Rousseau, για την έννοια της γενικής βούλησης σε αντιπαραβολή με τις θέσεις του Ισπανού θεωρητικού της φασιστικής ιδεολογίας, Primo De Rivera, επισημαίνοντας την πρόσληψη του Rousseau από τον τελευταίο, καθώς και τον τρόπο που ορίζουν αμφότεροι την εν λόγω έννοια. Πιο συγκεκριμένα, θα υποστηριχθεί ότι η ρουσωική άποψη περί λαού και γενικής βούλησης εμπεριέχει τάσεις από τις οποίες θα μπορούσε να δικαιολογηθεί θεωρητικά ο φασισμός. Η θέση αυτή θα προβληθεί μέσα από τη συγκριτική εξέταση της ρουσωικής πραγματείας Κοινωνικό συμβόλαιο με τους Λόγους μάχης του De Rivera, ώστε να γίνει αντιληπτή η εννοιολογική μετάβαση από τη volonté générale στην έννοια «λαός», όπως την αντιλαμβάνεται ο φασισμός.
Η πολιτική σκέψη των σοφιστών στο έργο του Rousseau
Authors: Μπαρμπαρούσης Γεώργιος Σπ.
Published: July 2022

Οι πολιτικές απόψεις του Γάλλου διαφωτιστή Rousseau επηρεάστηκαν σημαντικά από την πολιτική σκέψη των σοφιστών. Είναι γνωστό πως ο Πλάτων δεν ήταν αμερόληπτος με τους σοφιστές και αυτό μας εμποδίζει να εκτιμήσουμε τη σημασία του έργου τους στην έρευνα και την ερμηνεία των κοινωνιών και πολιτικών θεσμών της εποχής τους. Ωστόσο ο J. J. Rousseau, στο έργο του Κοινωνικό Συμβόλαιο, συμφωνεί με την άποψη του σοφιστή Λυκόφρονος πως υπάρχει μια νομική σχέση ανάμεσα στον άνθρωπο και το κράτος και πως ο νόμος είναι μια σύμβαση η οποία εγγυάται των δικαιωμάτων των συμβαλλομένων. Αυτό το κοινωνικό συμβόλαιο προβάλλει ως αναγκαίο για την προστασία όλων των μελών της κοινωνίας και το θέτει η ίδια η κοινότητα και όχι κάποια μεταφυσική αρχή ή πηγή.
Το χρέος του φιλοσόφου
Authors: Βλάχος Αντώνιος
Published: July 2022

Σε όσους ασχολούνται με την επιστήμη της Φιλοσοφίας, καθώς ως τέτοια λογίζεται και μάλιστα, περαιτέρω, ως επιστήμη των επιστημών, γεννάται το εύλογο ερώτημα σχετικά με το ποιος πρέπει να καλείται φιλόσοφος και, τελικά, ποιο χρέος οφείλει να επιτελέσει ως προς το «ποίμνιόν» του. Πρόκειται, με άλλους λόγους, για μία ενδοσκόπηση, για μια αυτοαναφορά, ώστε να αυτοαποκαλείται ως τέτοιος και να εξυπηρετεί στο έπακρο τον σκοπό του. Με αφετηρία την αρχαία ελληνική φιλοσοφία, επιτελείται μια πρώτη προσπάθεια ορισμού και νοηματοδότησης του υπό εξέτασιν ζητήματος, δίνοντας εκ παραλλήλου το στίγμα της διαχρονικότητας, σύμφωνα με τη σύγχρονη τάξη πραγμάτων.
Ηθικές και αισθητικές ποιότητες στη ρωμαϊκή τέχνη
Authors: Καραμπάτος Ηρακλής Π.
Published: July 2022

Η ρωμαϊκή αισθητική αποτελεί απότοκο των πολιτισμικών ωσμώσεων της ρωμαϊκής πολιτείας με τον ελληνιστικό κόσμο, καθώς σήμερα είναι εμφανές πως πολλά χαρακτηριστικά της αποτελούν δάνεια από τη φιλοσοφία της ελληνιστικής τέχνης. Φυσικά, η ρωμαϊκή αισθητική δεν είναι μια «ετερόνομη» αισθητική, καθότι ανέπτυξε και τα δικά της χαρακτηριστικά, όπως είναι, για παράδειγμα, η εισαγωγή νέων αισθητικών εννοιών ως αισθητικών κριτηρίων για τον καθορισμό και την ταξινόμηση ενός έργου ως ωραίου ή όχι (π.χ. χρηστικότητα). Η ρωμαϊκή αισθητική χαρακτηρίζεται περισσότερο από την αλληλοσυμπλοκή της με την ηθική και την πολιτική της Ρώμης. Πάνω σε αυτόν τον άξονα κινείται η μορφοποίηση της ρωμαϊκής τέχνης, ήδη από την πρώιμη δημοκρατική περίοδο (509 π.Χ.). Τα βασικά χαρακτηριστικά της ρωμαϊκής αισθητικής είναι ένας προβαλλόμενος μοραλισμός που προκρίνει τις ηθικές αξίες εις βάρος των αισθητικών ποιοτήτων, η επιζήτηση του «γιγάντιου» και η μορφοποίηση και πρόσληψη της τέχνης υπό ένα πρίσμα συναφειοκρατίας, παρά υπό ένα πρίσμα απομονωτισμού.
Η Ιστορία στη διαφήμιση: Οι τηλεοπτικές διαφημίσεις (2000-2019)
Authors: Ταμίσογλου Χρύσα
Published: July 2022

Στις μέρες μας, η ενασχόληση με την Ιστορία δεν αποτελεί αποκλειστικό προνόμιο των ακαδημαϊκών. Με τη εξάπλωση της τεχνολογίας και τη διείσδυση των ΜΜΕ σε κάθε έκφανση της καθημερινότητας, υφίσταται διάχυσή της στη δημόσια σφαίρα, συγκροτώντας το πεδίο της Δημόσιας Ιστορίας. Στο εν λόγω πεδίο, η τηλεόραση παίζει πρωταγωνιστικό ρόλο για τη μετάδοση των ιστορικών γνώσεων σε σημείο που να γίνεται πλέον λόγος για edu-tainment ή και histo-tainment» (εκπαιδευτική, ιστορική διασκέδαση). Η παρούσα μελέτη εξετάζει τη σχέση της Ιστορίας με την τηλεοπτική διαφήμιση και καταλήγει στο συμπέρασμα ότι η θέση της Ιστορίας στην τηλεοπτική διαφήμιση εκτείνεται πέρα από την εκπαιδευτική, ιστορική διασκέδαση. Διαπραγματεύεται τον όρο ιστοριο-κατανάλωση (histo-consuming) υποδεικνύοντας ότι πλέον η Ιστορία αποτελεί μέσο για την κατανάλωση αγαθών, προσδιορίζοντας ένα νέο πεδίο της προσέγγισης της ιστορικής γνώσης.
Η επίδραση της βιογραφίας στην άσκηση «ηγεσίας»: Πρακτικές οργάνωσης και διοίκησης διευθυντών σχολείων
Authors: Αλεξίου Πολυξένη , Ζιώγα Στυλιανή , Μπανάσου Βαΐα , Ράπτη Ειρήνη-Αγλαΐα , Τριανταφύλλου Χαρίκλεια , Φωτίου Κωνσταντίνος , Χίλαϊ Άντζελα , Λιακοπούλου Μαρία
Published: July 2022

Το παρόν άρθρο συντάχθηκε με στόχο να γίνει αντιληπτός ο τρόπος άσκησης της ηγεσίας αλλά και οι καθημερινές πρακτικές διευθυντών, μέσα από την αφήγηση προσωπικών εμπειριών επτά Ελλήνων διευθυντών. Η έρευνα που παρουσιάζεται διεξήχθη με ποιοτική προσέγγιση και η μέθοδος συλλογής και ανάλυσης δεδομένων είναι η βιογραφική. Μέσα από την έρευνα και τις μαρτυρίες των διευθυντών αναδεικνύεται ο τρόπος με τον οποίο οι προσωπικές εμπειρίες και οι απόψεις των «ηγετών», επηρεάζουν τις πρακτικές διοίκησης και οργάνωσης που αποφασίζουν να υιοθετήσουν. Το εν λόγω άρθρο τονίζει τη διαφορετικότητα και τη μοναδικότητα των βιωμάτων που ολοκληρώνουν και καθορίζουν την πορεία ενός ατόμου.
Δίκτυο Εκπαιδευτικών «Εκπαιδευτικός και σύγχρονες προκλήσεις»
Authors: Λιακοπούλου Μαρία
Published: July 2022

Δίκτυο Εκπαιδευτικών «Εκπαιδευτικός και σύγχρονες προκλήσεις»
Ημερίδα με θέμα «Ισότητα και ποιότητα στην εκπαίδευση σε καιρό πανδημίας»
Authors: Λιακοπούλου Μαρία
Published: July 2022

Ημερίδα με θέμα «Ισότητα και ποιότητα στην εκπαίδευση σε καιρό πανδημίας»
Δράσεις του Εργαστηρίου Εκπαιδευτικής Ψυχολογίας, Συμβουλευτικής και Έρευνας την περίοδο της πανδημίας COVID-19
Authors: Μπρούζος Ανδρέας
Published: July 2022

Δράσεις του Εργαστηρίου Εκπαιδευτικής Ψυχολογίας, Συμβουλευτικής και Έρευνας την περίοδο της πανδημίας COVID-19
Διαλέξεις για τα 200 χρόνια από την Επανάσταση
Authors: Ταμίσογλου Χρύσα
Published: July 2022

Διαλέξεις για τα 200 χρόνια από την Επανάσταση
Lower serum BDNF as a predictor of post-stroke cognitive impairment in acute ischemic stroke patients
Authors: Setyopranoto Ismail , Prodjohardjono Astuti , Sutarni Sri , Susianti Noor Alia , Hardhantyo Muhammad , Vidyanti Amelia Nur
Published: July 2022

Background: Reduced level of serum BDNF in acute stroke patients is associated with poor outcomes. We aimed to identify the role of serum BDNF level as a predictor for post-stroke cognitive impairment (PSCI).

Methods: This was a prospective study. We recruited acute ischemic stroke patients in Dr. Sardjito General Hospital Yogyakarta, Indonesia followed them up for 90 days (3 months). Serum BDNF was collected at day 5 and day 30 of stroke onset and measured by ELISA. Montreal Cognitive Assessment (MoCA) was used to measure the cognitive function at 90 days of follow up. ROC curve was conducted to measure the cut-off point of the BDNF level. Factors independently associated with PSCI were analyzed by using stepwise regression.

Results: Among 89 patients recruited, 60 patients (67.41%) developed PSCI. The mean age of PSCI and non-PSCI patients was 62.7 ± 9.5 and 57.5 ± 8.7, respectively (p = 0.01). Patients with dyslipidemia were less likely to develop PSCI (OR 0.19, 95%CI 0.06–0.56, p < 0.05). In addition, patients with day 5-serum BDNF level < 23.29 ng/mL were five times more likely to develop PSCI compared with their counterparts (OR 5.02, 95%CI 1.67–15.04, p < 0.05).

Conclusions: Among acute ischemic stroke patients, those with serum BDNF <23.29 ng/mL had a higher risk of developing PSCI, while those with dyslipidemia had a lower risk of PSCI. This study suggests that BDNF could be a predictor of PSCI, allowing for earlier detection and better preventive strategies.
Single-incision laparoscopic cholecystectomy versus conventional multi-port laparoscopic cholecystectomy: A systematic review, meta-analysis, and meta-regression of randomized controlled trials
Authors: Rudiman Reno , Hanafi Ricarhdo Valentino , Wijaya Alma
Published: July 2022

Background: Conventional multi-port laparoscopic cholecystectomy (CMLC) has become the current ‘gold standard’ technique in gallbladder disease. Single-incision laparoscopic cholecystectomy (SILC) has gained attention due to its benefits in improving patient cosmetic results and pain reduction. We aim to assess the latest evidence on the feasibility, safety and surgical outcomes of SILC and CMLC.

Methods: We conducted searches for randomized controlled trials (RCTs) in PubMed, PubMed Central (PMC), and Europe PMC between December 2011 and 2021. The latest search was conducted in January 2022. We analyzed several outcomes, including perioperative complications, estimated blood loss, operation time, conversion to open surgery, hospital stay, pain score, cosmesis, and days of return to work. Cochrane Risk of Bias (RoB) 2.0 tool was used to evaluate quality of studies. Mantel-Haenszel's formula and Inverse Variance method were conducted to synthesize results. This study was accomplished in accordance with the PRISMA guidelines.

Results: A total of 37 studies were eligible, with a total of 2,129 and 2,392 patients who underwent SILC and CMLC. Our study demonstrated a superiority of SILC for the visual analog score (VAS) at six hours post-operation [mean difference (MD) -0.58 (95% CI -1.11, -0.05), p=0.03], cosmesis one-month post-operation [standard MD 2.12 (95% CI 1.10, 3.13), p<0.0001], and cosmesis six months post-operation [standard MD 0.53 (95% CI 0.06, 0.99), p<0.0001]. Meanwhile, SILC showed a longer operation time [MD 10.45 (95% CI 6.74, 14.17), p<0.00001]. In terms of VAS at four time points (4, 8, 12, and 24 hours), perioperative complications, estimated blood loss, conversion to open surgery, hospital stay and days to return to work, SILC did not differ from CMLC.

Conclusions: SILC is a safe, feasible and favorable procedure in terms of pain reduction and cosmetic results. The option between both procedures is based on surgeon preferences.

Registration: PROSPERO (CRD42022306532; 23 February 2022).
La dimensión transnacional de la diplomacia uruguaya en España (1917-1930).
Authors: Cagiao Vila Pilar
Published: July 2022

Esta contribución acomete la trayectoria del uruguayo Benjamín Fernández y Medina, quien desde 1917 ejerció como ministro plenipotenciario en España hasta que en 1930 fue trasladado a La Habana. Su gestión diplomática estrictamente vinculada a las relaciones bilaterales, que aquí se aborda solo de manera tangencial, adquirió una dimensión transnacional, impulsada desde el escenario español, al ocuparse de la representación de su país en Portugal y ante la Asamblea de la Sociedad de Naciones.
Prácticas, iniciativas y resolución de conflictos diplomáticos transnacionales. La labor de la embajada argentina en la Exposición Iberoamericana de Sevilla.
Authors: Zaidenwerg Cielo
Published: July 2022

Esta propuesta busca reconstruir y analizar la labor, voluntad y posición de algunos diplomáticos argentinos durante los años centrales del gobierno del general Primo de Rivera y en el contexto europeo de entreguerras. Para su desempeño tuvo especial relevancia la Exposición Iberoamericana en Sevilla inaugurada en 1929 que dio lugar a numerosas actividades, compromisos oficiales y culturales en España. A través de este análisis, indagaremos en los mecanismos institucionales y prácticas personales que supieron tejer estos protagonistas pertenecientes a la red diplomática, para resolver ciertos conflictos transnacionales a medida que se iban desarrollando los acontecimientos, como ocurriría con la celebración del 12 de octubre de ese mismo año.
Una imaginación transnacional: el cónsul y cronista Avelino Rodríguez Elías entre Vigo, Paraguay, el Río de la Plata y Portugal (1916-1936).
Authors: D. Webb Philip
Published: July 2022

Este artículo pretende devolver al cónsul y escritor Avelino Rodríguez Elías a su contexto transnacional con el propósito de encontrar las relaciones entre diversas facetas de su producción intelectual, y de reconstruir una parte mínima de la red de interconectividad por la que Vigo se caracterizaba durante el primer tercio del siglo XX. Se profundiza sobre todo en el texto escrito y en el asociacionismo como elementos clave detrás de dicho contexto.
El comercio de vino de Castilla y de la tierra en Arequipa colonia (1540-1600).
Authors: Málaga Núñez-Zeballos Alejandro
Published: July 2022

: El presente artículo analiza el origen y evolución de la producción y comercialización del vino en Arequipa, teniendo como base documental los manuscritos de compra y venta y los acuerdos municipales para regular su mercadeo y medio de transporte. A partir de la interpretación de las cláusulas de compra y venta se reconstruyen dos etapas: el vino traído de la península ibérica y el vino producido en jurisdicción arequipeña.
Prenatal ve Postnatal Dönemde Tanı Alan Konjenital Akciğer Malformasyonu Olan Çocukların Değerlendirilmesi
Authors: RAMASLI GÜRSOY Tuğba , ŞİŞMANLAR EYÜBOĞLU Tuğba , ASLAN Ayşe Tana , KARABULUT Ramazan , TAŞTEPE Abdullah
Published: July 2022

Amaç: Çalışmamızda prenatal ve postnatal dönemde tanı alan konjenital akciğer malformasyonu olan hastaların klinik özelliklerini
karşılaştırmayı amaçladık.
Gereç ve Yöntemler: 2007-2021 yılları arasında Çocuk Göğüs Hastalıkları Bölümü’nde izlenen konjenital akciğer malformasyonu olan
hastalar cinsiyetleri, yaşları, başvuru yakınmaları, ilk semptom zamanı, tanı yaşları, tanı yöntemleri, doğum haftaları, doğum ağırlıkları,
ebeveyn akrabalığı, operasyon varlığı, operasyon yaşı ve endikasyonları, uzun dönem komplikasyonları açısından değerlendirildi. Prenatal
dönemde tanı alan hastalar ile postnatal dönemde tanı alanlar klinik özellikleri açısından karşılaştırıldı.
Bulgular: Konjenital akciğer malformasyonu nedeniyle izlenen 37 hastanın ortalama yaşları 6.7±5.8 yıldı ve 17’si (%45.9) kızdı. Prenatal
dönemde tanı alan hastalar (n:18) yakınması olmadan başvururken diğer hastaların en sık başvuru nedenleri öksürük ve tekrarlayan akciğer
enfeksiyonuydu. Postnatal dönemde tanı alan hastaların (n:19) ortanca tanı yaşları 30 (en küçük:10; en büyük:1080) gündü. Hastaların
18’i (%48.6) prenatal ultrasonografi, 14’ü (%37.8) bilgisayarlı tomografi, beşi (%13.6) akciğer grafisi ile tanı aldı. İzlemde iki hastanın
malformasyonu kendiliğinden geriledi. Oniki hasta opere olurken diğer hastalar mevcut anomalileri ile takip edilmektedir. Prenatal dönemde
tanı alan hastaların asemptomatik izlem süresi, postnatal tanı alan hastalardan istatistiksel olarak anlamlı farklıydı (36.5±4.7 ve 24.0±12.7
ay) (p:0.004).
Sonuç: Çalışmamızda prenatal dönemde tanı alan konjenital akciğer malformasyonu olan hastaların daha uzun süre
Autofocusing luminal and superluminal spatiotemporally localized waves
Authors: Besieris Ioannis M. , Saari Peeter
Published: July 2022

Highly focused space-time wavepackets in free space have already been achieved by means of suitable superpositions of nondiffracting and almost undistorted spatiotemporally localized pulses. Here, we present analytically individual autofocusing luminal and superluminal localized waves that can attain high-intensity peaks and spatiotemporal localization at prespecified positions along the path of their propagation.
On the acceptance of intergenerational climate legacies: A comparison of Canada and Japan
Authors: Adachi Kyoko , Dowlatabadi Hadi , Zhao Jiaying
Published: July 2022

Intergenerational climate justice negotiations often flounder on three questions: What was the outcome on climate change? Was it intentional? Why should the current generation pay for the misdeeds of previous generations? In this research, participants from Japan and Canada rated their willingness to accept intergenerational climate legacies and the responsibilities these legacies entail; judged the importance of intent and outcome associated with creating these legacies; and rated their willingness to compensate those negatively impacted by previous generations. The study found: a) while outcome was important, intent did not matter; b) Canadians were more likely to accept an inheritance and c) more likely to equivocate, in acceptance, if it entailed obligations than the Japanese; d) among those who accepted the inheritance, Japanese were more generous in settlement of previous generation’s obligations; e) lower-income, non-Judeo-Christian participants were systematically fairer than others; and f) the resistance to compensation for past generations’ actions was diminished with the awareness about the broad scope of intergenerational climate legacies that the current generation enjoyed. Our findings highlight the influences of culture and historic awareness on accepting climate responsibilities for actions of previous generations and willingness to provide compensation. The findings also support abandoning the debate on intentionality.
Integrating interferon-gamma release assay testing into provision of tuberculosis preventive therapy is feasible in a tuberculosis high burden resource-limited setting: A mixed methods study
Authors: Muchuro Simon , Makabayi-Mugabe Rita , Musaazi Joseph , Mayito Jonathan , Zawedde-Muyanja Stella , Nakawooya Mabel , Tugumisirize Didas , Semanda Patrick , Wandiga Steve , Nabada-Ndidde Susan , Nkolo Abel , Turyahabwe Stavia
Published: July 2022

The World Health Organization recommends the scale-up of tuberculosis preventive therapy (TPT) for persons at risk of developing active tuberculosis (TB) as a key component to end the global TB epidemic. We sought to determine the feasibility of integrating testing for latent TB infection (LTBI) using interferon-gamma release assays (IGRAs) into the provision of TPT in a resource-limited high TB burden setting. We conducted a parallel convergent mixed methods study at four tertiary referral hospitals. We abstracted details of patients with bacteriologically confirmed pulmonary tuberculosis (PBC TB). We line-listed household contacts (HHCs) of these patients and carried out home visits where we collected demographic data from HHCs, and tested them for both HIV and LTBI. We performed multi-level Poisson regression with robust standard errors to determine the associations between the presence of LTBI and characteristics of HHCs. Qualitative data was collected from health workers and analyzed using inductive thematic analysis. From February to December 2020 we identified 355 HHCs of 86 index TB patients. Among these HHCs, uptake for the IGRA test was 352/355 (99%) while acceptability was 337/352 (95.7%). Of the 352 HHCs that were tested with IGRA, the median age was 18 years (IQR 10–32), 191 (54%) were female and 11 (3%) were HIV positive. A total of 115/352 (32.7%) had a positive IGRA result. Among HHCs who tested negative on IGRA at the initial visit, 146 were retested after 9 months and 5 (3.4%) of these tested positive for LTBI. At multivariable analysis, being aged ≥ 45 years [PR 2.28 (95% CI 1.02, 5.08)], being employed as a casual labourer [PR 1.38 (95% CI 1.19, 1.61)], spending time with the index TB patient every day [PR 2.14 (95% CI 1.51, 3.04)], being a parent/sibling to the index TB patients [PR 1.39 (95% CI 1.21, 1.60)] and sharing the same room with the index TB patients [PR 1.98 (95% CI 1.52, 2.58)] were associated with LTBI. Implementation challenges included high levels of TB stigma and difficulties in following strict protocols for blood sample storage and transportation. Integrating home-based IGRA testing for LTBI into provision of TB preventive therapy in routine care settings was feasible and resulted in high uptake and acceptability of IGRA tests.
Small sight—Big might: Economic impact of bird tourism shows opportunities for rural communities and biodiversity conservation
Authors: Schwoerer Tobias , Dawson Natalie G.
Published: July 2022

Birdwatching is considered one of the fastest growing nature-based tourism sectors in the world. Tourists who identify as birdwatchers tend to be well-educated and wealthy travellers with a specific interest in the places they visit. Birdwatchers can bring economic resources to remote communities diversifying their economies and contribute to biodiversity conservation in areas of bird habitat with global significance. Alaska plays a critical role in understanding the link between bird conservation and bird tourism as it supports the world’s largest concentration of shorebirds and is a global breeding hotspot for hundreds of migratory species, including many species of conservation concern for their decline across their ranges. Alaska is also a global destination for birders due to the large congregations of birds that occur during the spring, summer and fall seasons. Despite its global importance, relatively little information exists on the significance of bird tourism in Alaska or on opportunities for community development that align with conservation. This study used ebird data to look at trends in Alaska birdwatching and applied existing information from the Alaska Visitor Statistics Program to estimate visitor expenditures and the impact of that spending on Alaska’s regional economies. In 2016, nearly 300,000 birdwatchers visited Alaska and spent $378 million, supporting approximately 4,000 jobs. The study describes bird tourism’s contributions to local jobs and income in remote rural and urban economies and discusses opportunities for developing and expanding the nature-based tourism sector. The study points toward the importance of partnering with rural communities and landowners to advance both economic opportunities and biodiversity conservation actions. The need for new data collection addressing niche market development and economic diversification is also discussed.
Expression of miR-221 and miR-18a in patients with hepatocellular carcinoma and its clinical significance
Authors: Yun Jong Hyuk , Baek Moo-Jun , Jung Hae Il
Published: July 2022

Purpose: Recently, microRNA (miRNA) has been evaluated to provide a new diagnostic and therapeutic modality hepatocellular carcinoma (HCC) and other tumors. They are small non-coding RNA molecules that function as transcriptional and post-transcriptional regulators of gene expression by silencing target genes. The aim of this study was to evaluate the clinical significance of microRNA-18a, 221 (miR-18a, miR-221) expression in HCC formalin-fixed paraffin-embedded (FFPE) tissue.Methods: miR-18a and miR-221 expressions were assessed by reverse transcription and real-time quantitative reverse transcription polymerase chain reaction in 50 pairs of FFPE HCC and the adjacent noncancerous liver tissues. And we evaluated the expression level in HCC tissues as compared with their adjacent noncancerous counterparts. And the relationship between miR-18a, miR-221 level and clinicopathological data and survival rates were analyzed.Results: miR-221 and miR-18a were overexpressed in HCC tissue as compared with their adjacent noncancerous liver tissue (P<0.001). miR221 expression was found to be correlated with larger tumor size (P=0.048). miR-18a expression was correlated with modified Union for International Cancer Control stage (P=0.05). The overall survival (P=0.02) of HCC patients with high miR-221 expression was significantly poorer compared to those patients with low expression. Multivariate analyses demonstrated that miR-221 may be a poor prognostic factor of HCC patients.Conclusion: High expression of miR-221 in FFPE tissues could provide significance for prognosis of HCC patients. Although, miR-18a expression was significantly upregulated in HCC tissues, they are not correlated with prognosis. Further large prospective studies are needed to determine their clinical significance.
Jejunogastric intussusception after totally laparoscopic distal gastrectomy for gastric cancer: a rare case report and review of the literature
Authors: Song Geum Jong , Yun Jong Hyuk , Jung Hae Il , Son Myoung Won , Lee Moon-Soo
Published: July 2022

Jejunogastric intussusception (JGI) is a rare complication of gastric surgery, with most cases occurring in the form of long-term complications following gastric surgeries. We present a case of JGI in a 74-year-old man who presented with progressive abdominal pain and distention, and was admitted to our hospital. The patient had undergone a totally laparoscopic distal gastrectomy with a Billroth II gastrojejunostomy 9 days previously. Computed tomography and endoscopic findings revealed the presence of a small bowel loop within the gastric lumen, which we failed to reduce in size. We performed an emergency laparoscopic exploration and immediate reduction of the JGI. The efferent and afferent loops were then fixed to the mesentery and the stomach. The postoperative course was uneventful and the patient remained asymptomatic during the 1-year follow-up period.