bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of parameters of open-pit screening and dumping stations
Authors:   Institute of Mining of the Ural Branch of RAS, KANTEMIROV Valeriy Daniilovich , TITOV Roman Sergeevich ,   Institute of Mining of the Ural Branch of RAS
Published: November 2020

Introduction. The mining and geological features of a number of deposits lead to the fact that during the development of the massif under the influence of drilling and blasting operations, the degree of crushing of a mineral depends on the content of useful components in it, and the chemical composition of the ore is differentiated by size classes. The determined relationship between the quality of the ore mass and its size can be used to increase the efficiency of the ore preparation technology through the use of screening and dumping stations (SDS) in open pits. The implementation of the ore preparation technology based on the SDS will allow to reduce the costs of enrichment and transportation of the ore mass by separating its substandard part directly in the open pit and excluding it from the traffic flow at the processing plant, where the efficient operation of SDS is possible by optimizing a number of parameters as mining transport equipment serving SDS and a screener itself. Results. To determine the main parameters of SDS the characteristics of the initial movement of the rock mass along the inclined surface of the screen were determined, such as the productivity of unloading the vehicle onto the surface, the initial thickness of the layer for feeding and the speed of movement of the rock mass along the slope of the screener. Based on the presented algorithm, the main characteristics of the screening process are calculated: the size of the material flow layer in the i-th screener section; the speed of movement of the bulk mass along the screener; the average size of a piece in the starting material and the output of the material into screen throughs. The parameters of the screening process were determined on the basis of a given relative content of the size class of the material supplied to the surface of the screener, subject to its uniform distribution within the class. The optimized parameters of SDS were selected: the angle of inclination of the screener and the linear dimensions of the unloading platform, depending on the dimensions of the dump truck. Determination of the optimal parameters of SDS was carried out by constructing a generalized desirability function for two optimized criteria: the material yield to screen throughs and the oversize of the screener. Based on results of the calculation, optimization graphs of the dependence of the optimization function on the angle of inclination of the surface of the screener and the carrying capacity of the dump truck unloaded onto the screener were constructed. Conclusions. The optimal angle of inclination of SDS screen is 40° –42° and does not depend on the grain size distribution of the feedstock supplied to screening.
Study of the quality construction of photogrammetric models obtained in low-light conditions
Authors:   Saint-Petersburg Mining University, SUKHOV Arseniy Konstantinovich , VYSTRCHIL Mikhail Georgievich ,   Saint-Petersburg Mining University, GUSEV Vladivir Nikolaevich ,   Saint-Petersburg Mining University, BLISHCHENKO Aleksandr Aleksandrovich ,   Saint-Petersburg Mining University, DAN’KO Andrey Viktorovich ,   Saint-Petersburg Mining University
Published: November 2020

Relevance of the research topic. The paper shows main results of environmental parameters that affect the quality of 3D-models obtained by the photogrammetric method of surveying. Research objective. The article presents: the fundamental possibility of using a small-sized photogrammetric device for underground surveying and the parameters that affect the result of shooting in a confined low-light space. Research methods. Experiments included a set of independent serial photographs of a test site. To increase the results of experiments, object with a simple geometric shape have been used as test objects for extrapolating of the results of the survey to products of standard metal products. In these conditions, imitating abstract underground mine workings: with the lack of lighting, confined spaces, a small number of characteristic points in the background. The texture of the subject of photogrammetric survey and common geometric parameters of photo base accepted as studied factors. Various images were projected onto the test scene to form an artificial texture. Results and its applications. The experimental results confirm the possibility of using the proposed methods for identifying engineering communications nodes, oil and gas production facilities, elements of lifting machines and conductors in vertical mining devices. In addition, the authors performed an idea of improving the quality of photogrammetric models by projecting temporary artificial textures on the subject. The results of the work can be used for the improving of the methods of surveying, using digital photogrammetry technology Findings. It is possible to imrove the quality of digital photogrammetric models of engineering structures by projecting artificial textures onto them. The possibility of the creation of models of the subject increases the accuracy and controllability of the result. With increasing contrast and complexity of the texture being applied, digital photogrammetry algorithms better determine the correspondence between a pair of photographs.
Quality management of mined rock based on the use of mathematical modeling technologies
Authors:   Russian State Geological Prospecting University, named after Sergo Ordzhonikidze, NAZAROVA Zinaida Mikhailovna , ZABAIKIN Yuriy Vasil’evich ,   Russian State Geological Prospecting University, named after Sergo Ordzhonikidze, LEONIDOVA Yuliya Anatol’evna ,   Russian State Geological Prospecting University, named after Sergo Ordzhonikidze, YAKUNIN Mikhail Arkad’evich ,   Moscow University for Industry and Finance “Synergy”
Published: November 2020

Relevance. Fracturing of the array is one of the main factors in the formation of quality blocks of decorative stone. Systems of natural cracks form a separate rock and determine the shape and size of structural blocks, which determines the possible output of conditioned block products from the array, the choice of the method of preparing the rock for excavation, the location and direction of movement of the mining front in accordance with the nature, intensity and elements of the occurrence of cracks. To control the quality of decorative stone blocks, modeling and forecasting optimal parameters, it is necessary to investigate the possibility of identifying fractures and then determining their geometric parameters using modern digital equipment. Purpose of research is to analyze the quality management of the extracted rock based on the use of mathematical modeling technologies. The methodology of the work consists in using methods of mathematical modeling, as well as statistical data processing. Results. The practical application of the results is to apply the developed methods in order to optimize the quality management system of the extracted rock and increase its efficiency. As a result of practical research, a rational ledge height of 5.8 m has been established for the conditions of the granodiorite Deposit, which allows to ensure the necessary production capacity of the quarry, high productivity of mining equipment, safety of mining operations, minimal economic costs for mining operations, low production costs and minimal losses of block raw materials. Conclusions. The analysis of the complex of mining operations of mining enterprises allows us to make a conclusion about the need to introduce new technologies into production that would ensure the automation of work, increase the reliability of measurement results and calculations. At the same time, automation should be based on the use of remote methods for assessing the quality of decorative stone, new electronic devices and appropriate software.
Nikolai Konstantinovich Vysotsky
Authors:   1 Ural State Mining University, SHORIN Aleksandr Georgievich
Published: November 2020

Nikolai Konstantinovich Vysotsky was a prominent scientist in the field of ore geology, in particular, he was the largest expert in the Ural platinum and gold, as well as the discoverer of platinum in the Norilsk fields.
On the finding of zincohögbomite in the granite pegmatites of the Lipovskiy vein field (Middle Urals)
Authors:   The Zavaritsky Institute of Geology and Geochemistry of the Ural Branch of RAS, ZAKHAROV Аnatoliy Vladimirovich
Published: November 2020

The relevance of the work is due to the need to study the mineralogy of granite pegmatites of the Lipovskiy vein field, a unique object that gave the world a large amount of crystal raw materials of colored tourmaline Purpose of the work: study of zincohögbomite found in granite pegmatites of the Lipovskiy vein field (Middle Urals). Research methodology: quantitative analysis of the chemical composition of magnetite was carried out using the X-ray spectral electron probe microanalyzer CAMECA SX 100 (The Zavaritsky Institute of Geology and Geochemistry of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg). The chemical composition of zincohögbomite was determined using the Jeol JSM-6390LV scanning electron microscope with an INCA Energy 450 X-Max 80 energy dispersive attachment from Oxford Instruments (The Zavaritsky Institute of Geology and Geochemistry of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg). Results. When studying the surface of magnetite crystals, pore spaces were found inlaid with flattened grains of an unknown mineral, mainly triangular, less often hexagonal, in shape, up to 2–3 microns in size. Based on the data on its chemical composition, this mineral was assigned to zincohögbomite. Based on crystallochemical calculations, it was found that the mineral corresponds to zincohögbomite-2H2S or zincohögbomite-8H according to the old classification. Conclusions. A new mineral was found for granite pegmatites of the Lipovskiy vein field – zincohögbomite-2H2S. It was found in the form of inclusions in magnetite individuals in common intragranite pegmatites. This is the second find of zincohögbomite in the Urals and, most likely, the first one in the world in granite pegmatites. The formation of zincohögbomite is associated with retrograde metamorphism of amphibolite facies, when primary spinels become unstable and decompose into several mineral phases. Zincohögbomite from Lipovskiy field was formed as a result of the decomposition of primary magnetite during the cooling of granite pegmatite.
Mineralogical and geochemical studies of gabbroids in the East Central Desert, Egypt
Authors:   Southern Federal University, AWAD Hamdy Ahmed Mohamed , NASTAVKIN Aleksey Valer’evich ,   Southern Federal University
Published: November 2020

Relevance of the work. The study area is limited to the Central-Eastern Desert of Egypt, represented by various rock units in addition to the gabbro rock containing iron oxides. Research Objective. This work is devoted to detailed studies of the geology of gabbroid rock minerals and iron oxides. Methodology. This work includes both field work (creation of a new geological map for various rock units in the study area) and laboratory work (preparation of thin sections for petrographic and mineralogical studies using a polarizing microscope and a scanning electron microscope SEM). Results and their application. Exploration and extraction of ore deposits and minerals in the eastern desert of Egypt is one of the most important goals for increasing the rate of mining in the country, which leads to economic recovery and meeting the needs of society. Previous work has focused on evaluating and studying economically mineral resources in the Central-Eastern Desert of Egypt. This place is considered one of the most promising mineral deposits in addition to the available iron oxide minerals. Geological studies show that the mineralization of iron oxide in the study area is mainly associated with gabbroid rocks, which carry iron oxide minerals in the form of groups and lenses in the lower part of the Earth’s layers, which is associated with magma rich in iron oxides. According to field studies, we found that iron minerals are represented by lenses up to 3 m thick, alternating with rock. Conclusions. The chemical analysis of minerals based on iron oxides was discovered using a scanning electron microscope (SEM) used to determine the chemical composition of these minerals, which are classified as minerals such as ilmenite and magnetite. Actually geochemical studies have shown that they have a high content of total iron oxides.
Shear Cell Test and Hopper Design
Authors:   James Cook University, ARNOLD Lukas , KUMAR Tarun ,   James Cook University, COWLEY Joshua ,   James Cook University, WHEATLEY Greg ,   James Cook University, CHANDRASIRI Rendage Sachini Sandeepa ,   University of Colombo
Published: November 2020

Relevance of the work. The Hopper and Bin design is the most commonly used technique of storing materials as it is a gravity fed system and is generally used for storing materials such as agricultural grains as well as mined minerals such as sand and coal. Mass flow, which is ideally the most desired flow type sees the bulk material travel uniformly with all particles in motion until all the material leaves the bin. The other types of flow generally occur with flat-bottomed bins with shallow hoppers are not seen as ideal as with this design problems such as arching and rat holing occur. The issue with the current design is that some of the material becomes stagnant in the bin, this can be costly as if the bulk material becomes stuck, degradation can occur over time. It can be observed for the Funnel and Expanded flow, the rat holing and arching occurring due to the stagnant material. Research Objective is to design a novel mass flow acrylic bin and hopper to store bulk quantities of sand without stagnation or degradation Methodology. Two separate experimental procedures were carried out including the measurement of the specific gravity of the sand, shear test and final hopper design. The data was then manipulated and plotted stress transformations and identified multiple key flow property constituents. Using values such as the yield loci and associative yield stresses the hopper half angle α and opening diameter B were tabulated. Results and Conclusions. The optimum opening diameter B for an uncompacted system is 2 mm and the hopper half angle α adjusted to 34.58o , this was tested and provided a successful mass flow hopper system. Overall, the techniques used with specific gravity and shear cell testing gave a sufficient insight into the appropriate procedure for designing efficient and accurate bin and hoppers. Then substituting the values gathered into the appropriate formulae provided a successful mass flow system for the intended bulk material which is sand.
RADIOGRAPHIC EVALUATION OF TELESCOPIC PIER ABUTMENTS IN MANDIBULAR DISTAL EXTENSION CASES
Authors:   Researcher, Department of Fixed and Removable Prosthodontics, National Research Centre, Egypt., H. Mostafa Marwah , M. Dehis Wessam ,   Ass. Research Prof., Department of Fixed and Removable Prosthodontics, National Research Centre, Egypt., S. ElGabry Hisham ,   Ass. Research Prof., Department of Fixed and Removable Prosthodontics, National Research Centre - MSA University, Egypt.
Published: November 2020

Purpose: The aim of this clinical study is to compare the effect of both definitive partial dentures and telescopic partial dentures on bone height changes around the terminal abutments in mandibular distal extension cases with pier abutment. Materials and Methods: Fourteen mandibular Kennedys Class I classification with pier abutment patients were divided into two equal groups. First group (I) received definitive metal-frame removable partial dentures (RPD), while the second group (II) received telescopic RPD. The supporting bone height around the terminal abutments was radiographically evaluated. Next to baseline recording following denture insertion, bone height measurements were obtained at regular recall follow-up appointments of 6, 12, 18 and 24 months. Radiographic evaluation was carried outusing the Digora system and customized acrylic template constructed for each patient individually. The linear measurement system supplied by the Digora machine software was utilized for recording bone height changes mesial and distal to the main terminal abutments. Results: Comparison was performed between definitive and telescopic groups utilizing independent t-test and resulted in differencesof no significant for all follow-up recalls (P value > 0.05). Conclusion:Definitive RPD and telescopic RPD appeared to besuccessful both clinically and biologically. However, Telescopic RPD proved to be superior to the definitive one regarding bone height measurements.
ACCOUNTABILITY IN PUBLIC PROCUREMENT: THE CASE OF FEDERAL PUBLIC ORGANIZATIONS OF ETHIOPIA
Authors:   Department of Public Financial Management and Accounting, Ethiopian Civil Service University,Addis Ababa, Ethiopia., Mentta (Ph.D.) Tadewos , Maldaye Mata ,   Department of Commerce and Management Studies, Andhra University,Visakhapatnam, India.
Published: November 2020

Public procurement is the main tool through which governments acquire goods, works, and services in the course of achieving public objectives. The study has focused on the accountability aspects of government procurement. The study has addressed the accountability in government procurement of the federal organizations of Ethiopia, and particular emphasis was given to ministries, agencies and commissions. Procurement accountability is related to being answerable to what has been planned, what has been implemented, what result has been achieved, and how the decisions have been made. Thus, the basic objective of the study is to examine procurement related accountability in selects federal organizations of Ethiopia. The research questions have been designed to examine how accountability related factors influence government procurement, and what areas are needed to be considered in promoting accountability. Accordingly, the data show that accountability in control of efficiency and effectiveness, ensuring value for money by taking the whole-life cost of acquisition is not strong enough in selection and awarding of suppliers, and professionalism and experiences are not created well to establish a strong accountability. It has been suggested that federal organizations have to revisit the accountability issues to obtain equivalent benefit from the amount they spend. Moreover, creating accountability to the successes as well as to failures will enhance answerability of individuals working in procurement related areas.
PREVALENCE OF DIAGNOSED TEMPOROMANDIBULAR DISORDERS IN CENTRAL KERALITE POPULATION- A CROSS SECTIONAL STUDY
Authors:   Professor, Department of Prosthodontics, Pushpagiri College of Dental Sciences, Thiruvalla, Pathanamthitta, Kerala, India., Susan Thomas Annie , Hannah Philip Ariel ,   2nd year BDS student, Christian Dental College, Ludhiana, Punjab, India., Oommen Philip ,   Lecturer, Department of Pulmonary Medicine, GTDMC Alappuzha, Kerala, India., Mathew T Aby ,   Professor& HOD, Dept. Of Prosthodontics, Pushpagiri College of Dental Sciences, Thiruvalla, Pathanamthitta, Kerala, India.
Published: November 2020

Aim: To investigate the prevalence of TMD in Central Keralite population. Materials and Methods: A representative population-based sample of 368 people was randomly selected of which 152 were men and 216 were females. A cross sectional study was conducted in both males and females aged 18-65 years. TMD prevalence was assessed by self- reported questionnaire. The diagnosis of TMD was based on Research Diagnosis Criteria for TMD (RDC-TMD) Axis1. Results: Of the total sample size selected, 51.35% had TMD. Of this, 53.2% of the females and 48.6% of the males were diagnosed to have TMD. TMD patients were categorised according to RDC TMD Criteria. In Category I (Myofascial pain dysfunction) - 47%, Category II (Internal derangement) - 51% and in Category III (Inflammatory Joint Disorder) - 2% Conclusion: The present study indicates that more than half of the general population in Central Kerala is affected by TMD. Proper awareness of this disorder and possible treatment options should be well informed to the general population.
Effects of inflation accounting on organizational decisions and financial performance in South African retail stores
Authors: Olarewaju Odunayo , Mbambo Mzwandile , Ngiba Brian
Published: November 2020

The inflation accounting technique allows a business to show or have a sensible picture of their gains due to present cost coordinates with present revenues. Thus, the effects of inflation accounting on organizational decisions and financial performance of Kwa-Zulu Natal retail stores were evaluated in this study. The study used a quantitative research method. A total of 161 completed questionnaires were received from respondents in the selected 20 listed stores in Kwa-Zulu Natal. Thus, the Exploratory Factor Analysis and linear regressions were employed in this study. The empirical study reveals how inflation accounting significantly impacts organizational decisions and financial performance of the retail business with such coefficients (F (1, 159) = 49.269, p < .0005; F (1, 159) = 28.959, p < .0005). The findings of this study highlighted positive relationships between the variables that were used. Thus, the study recommends that retail stores always consider inflation changes and apply inflation accounting techniques to make adjustments to produce more accurate results in their financial statements. Heated discussions now surround the basis of financial performance measurement via historical cost accounting. This influences their decision making and financial performance positively.
1% ivermectin in combination therapy regimens for rosacea
Authors: Khlystova E. A. , Savastenko A. L.
Published: November 2020

Introduction. The article provides latest data on modern methods of treating rosacea. The results of own clinical observations of patients with moderate to severe papulopustular rosacea receiving combination treatment and a comparative analysis of the efficacy of various therapy regimens are presented.Objective of the study. The aim of the study was to conduct a comparative analysis of the therapeutic efficacy of combination therapy using the ivermectin 1% topical drug combined with systemic therapy drugs (doxycycline, minocycline, isotretinoin).Materials and methods. We observed 37 patients with moderate to severe papulo-pustular rosacea subtype. The patients were divided into 4 groups (A, B, C, D). Patients in the control group received monotherapy with 1% ivemectin topical drug, patients in the other groups received combination therapy (1% ivermectin combined with low-dose doxycycline, minocycline and isotretinoin). The efficacy of the therapy was evaluated by measuring rosacea severity on the Scale for Diagnostic Assessment of Rosacea (SDAR), clinical manifestations according to the IGA (Investigator Global Assessment) criteria, and by assessing the patients' quality of life using the DLQI (Dermatology Life Quality Index) questionnaire before and after 3-month treatment.Results. The comparative analysis of changes in severity indicators of the skin process and quality of life in patients with moderate to severe papulopustular rosacea after topical and combination therapy showed that the results of the treatment in patients receiving combination therapy were more significant than those in the group receiving monotherapy.Conclusion. The concomitant use of 1% ivermectin and systemic drugs is most effective in patients with severe papulopustular rosacea subtype. The combination treatment tailored to the clinical forms and severity of rosacea allows to optimize the clinical results of the therapy, which significantly affects the patients' quality of life and opens up potential for an individual approach in the algorithms for the treatment of rosacea.
Dermatological morbidity of the rural areas' population of the Republic of Uzbekistan under the conditions of use of mineral fertilizers
Authors: Kamilov O. A. , Ostretsova M. N. , Kamilova R. T.
Published: November 2020

Introduction. Exogenous, in particular, environmental factors are among the most significant factors affecting the course of a number of dermatoses. A study of the effect of chemical use in agriculture on dermatological morbidity was conducted.Objective. To assess the features of dermatological morbidity in rural areas, depending on the load of mineral fertilizers per hectare of arable land and per capita.Materials and methods. The object of the study was persons aged 18 to 68 years living in two rural areas of the Tashkent region: Chinaz district - cotton sowing; Bostanlyk district - horticultural. Our research was used materials of statistical reporting on the volume of mineral fertilizers used, conducted screening testing, clinical examination and history taking.Results. The incidence of dermatological diseases was 2,5 times higher in the cotton growing area compared with the horticultural region (94,1 versus 38,2, p < 0,001). A comparative analysis of clinical manifestations in persons with dermatological diseases of two rural areas showed a higher degree of activity of the skin pathological process in the cotton growing area especially among people with diffuse and complicated variants of atopic dermatitis.Conclusion. Allergic diseases predominate in the structure of skin pathology in the examined areas of the Tashkent region. In a cotton-growing area, the manifestations of allergic dermatitis are characterized by a more severe course and frequent relapses. The results of the study show that both the dermatological service and the agricultural chemical management system of the Republic need to apply best practices to improve quality and to ameliorate problems.
Actual antihistamine therapy
Authors: Shabanov D. V. , Lutkovskaya Ju. E.
Published: November 2020

The significance of the issues of allergic diseases is not in doubt. It is difficult to find a person who has not suffered at least some Allergy symptom, not everyone develops diseases, but most people face Allergy symptoms. The prevalence of various allergic diseases is increasing every year, currently reaching 30% of the population, and the world health organization predicts it will reach 50% in the next few decades. The most common nosologies are allergic rhinitis, bronchial asthma, atopic dermatitis, urticaria, but there are many other conditions of hypersensitivity. This article addresses the issues of inflammatory reactions in General and specifically allergic inflammation, discusses the main aspects of the pathogenesis of allergic rhinitis and urticaria, and questions of drug therapy for these diseases. Most people are sure that they can take anti-allergic medications for allergies, and most often they are referring to antihistamines. Unfortunately, even some medical specialists lack an understanding of the specifics of antihistamine therapy. some people still believe that there are three or four generations of antihistamines, and patients use drugs not as prescribed by doctors, but on the recommendation of friends or pharmacists. Irrational use of antihistamines leads to a decrease in effectiveness, and it is not uncommon to discredit specific drugs and groups of drugs in General. This article demonstrates the results of various European and Asian studies on the effectiveness and safety of antihistamines and bilastin in particular, as well as their own experience of using antihistamines in practice.
Biocenosis management in the treatment of infectious and inflammatory diseases of the pharynx
Authors: Svistushkin V. M. , Nikiforova G. N. , Shevchik E. A. , Zolotova A. V. , Pobivantseva A. A.
Published: November 2020

The article deals with the treatment of acute inflammatory diseases of the oropharynx, which are an essential part of ENT pathology and are one of the main therapeutic and diagnostic tasks for an otorhinolaryngologist both on an outpatient basis and at the inpatient stage of medical care. It is known that most acute pharyngeal diseases have a viral etiology, do not have etiotropic treatment, and are treated mainly symptomatically. Nevertheless, many patients are irrationally prescribed systemic antibiotic therapy, which leads to an increase in global antibiotic resistance. There are known patterns of correlation between the practice of irrational prescribing of antibacterial therapy and peaks of antibiotic resistance in different countries. At the same time, local antimicrobials are often prescribed, many of which have a negative effect on the pharyngeal microbiome and contribute to bacterial superinfection. The appointment of this group of drugs is also unjustified, given the viral etiology of the pathological process. Acute infections of the upper respiratory tract, including the pharynx, often occur against the background of violation of mucosal immunity, which is the first barrier in the system of protection against respiratory infections. In the treatment of these diseases, it is important to use drugs that not only have antimicrobial properties, but also stimulate mucosal immunity and reparative processes. The solution in this situation can be the therapeutic use of various factors of local immunity that will not cause antibiotic resistance and bacterial superinfection, but will act synergistically with autologous factors of mucosal protection. This article provides an analysis of prospects of using one of such drugs in inflammatory pharynx diseases.
Histological evaluation of effect of PDGF-rich plasma on the tympanic membrane
Authors: Kriukov A. I. , Gurov A. V. , Bakhtin A. A. , Murzakhanova Z. V.
Published: November 2020

Introduction. Тo study the microscopic picture of the tissues of the perforated tympanic membrane after the introduction of blood plasma enriched with platelet growth factors into the perforated area of the tympanic membrane in the experiment.

Materials and methods. 36 rats (72 tympanic membranes) were examined. The animals were divided into 2 groups, the main and the control. The tympanic membrane was perforated in rats of both groups using sterile play. Animals of the main group were injected with a single application of autoplasm of blood enriched with platelet growth factors into the area of perforation of the tympanic membrane. The animals of the control group underwent only dynamic observation. The rats were withdrawn from the experiment in batches of 6 individuals on day 5, 10, 15 after the tympanic membrane perforation, then a histological assessment of the tissue regeneration of the tympanic membranes was performed. Results. In animals of the main group on the 5th day after perforation of the tympanic membrane, edema and disorganization of connective tissue were significantly less frequently recorded than in animals of the control group (p ≤ 0.05). Fibroblastic infiltration of tympanic membrane tissues was significantly more often observed in rats of the main group compared with rats in the control group (p ≤ 0.05). In rats of the main group on the 10th day after perforation of the tympanic membrane, edema and disorganization of the connective tissue of the tympanic membranes were noted significantly less frequently than in rats of the control group (p ≤ 0.05). Signs of fibroblastic infiltration and neoangiogenesis at the same time in animals of the main group were revealed significantly more often, in contrast to rats in the control group (p ≤ 0.05). In animals of the main group, on the 15th day after perforation of the tympanic membrane, fibroblastic infiltration and neoangiogenesis were revealed in all cases of observation, which significantly exceeded the corresponding indicators in the control group, and leukocyte infiltration in rats of the main group, in contrast to the previous stages of the study, was noted significantly less frequently. than in rats of the control group (p ≤ 0.05).

Conclusion. Earlier and complete regeneration of damaged tissues of the tympanic membrane under conditions of its traumatic perforation was noted in rats of the main group under the influence of PCOTFR. In rats of the main group, more organized collagen fibers, the presence of basophilic leukocytes, signs of neoangiogenesis, and extensive fields of fibroblasts were visualized.
Site-directed Fragnomics and MD Simulations Approaches to Identify Interleukin-2 Inhibitors
Authors: Khalil Ruqaiya , Usmani Saman , Nur-e-Alam Mohammad , Ahmed Sarfaraz , Ul-Haq Zaheer
Published: November 2020

Introduction:

The aberrant expression of Interleukin-2 (IL2), the chief regulator of immunity, is associated with many auto-immune diseases. At present, there is no FDA approved drug targeting IL2, which puts forth the need for small molecular inhibitors to block IL2 and its receptor interaction.

Methodology:

Herein, we used the contemporary fragnomics approach to design novel drug-like inhibitors targeting IL2. Briefly, the RECAP (Retrosynthetic Combinatorial Analysis Procedure) package implemented in MOE (Molecular Operating Environment check) software suite was utilised to obtain fragments fulfilling the ‘rule of three’ criteria for fragments. The binding site of IL2 was divided into three smaller grooves, and the fragments were docked to screen their affinity for a particular site, followed by site-directed RECAP synthesis.

Results:

A focused library of 10,000 compounds was prepared by re-combining the fragments according to their affinity for a particular site as observed in docking. Docking and subsequent analysis of newly synthesised compounds identified 40 privileged leads, presenting hydrogen bonding with basic residues of the pocket. A QSAR model was implied to predict the IC50 of the compounds and to analyse the electrostatic and hydrophobic contour maps. The resulting hits were found to be modest IL2 inhibitors with predicted inhibitory activity in the range of 5.17-4.40 nM. Further Dynamic simulation studies were carried out to determine the stability of the inhibitor-IL2 complex.

Conclusion:

Our findings underline the potential of the novel compounds as valuable pharmacological agents in diseases characterised by IL2 overexpression.
Empregados como agentes digitais de reputação da marca: caso "Essa Coca é Fanta, e daí?"
Authors: Peixoto João Guilherme Melo , Queiroz Sabrina Medeiros Wanderley de
Published: November 2020

This article presents aspects related to information consumption motivated by technology and how these new habits can impact companies based on the opinion of employees, as digital agents of brand reputation. The object of study is the endomarketing campaign “This Coca-Cola is Fanta. So what?”, Developed in 2017, which had wide repercussions due to the spontaneous sharing of employees. This result was analyzed based on the case study applying the theoretical framework of organizational communication.
O marketing e o monstro: um estudo sobre o marketing de Cloverfield
Authors: Toledo Luciano Augusto , Barros Henrique , Silva Lucas , Santos Verônica , Pinto Wilder
Published: November 2020

To compete with major productions, low-budget Hollywood studios seek to invest in different strategies to promote their productions and engage with their target audience. Within this proposal, Cloverfield franchise producers developed in 2008 a viral marketing-based strategy. By the Collective Subject Speech, the researchers sought out to understand how this strategy was developed, how it was implemented, and whether the film's success was due to the implemented campaign. The results obtained through qualitative analysis show that the good results achieved by the film are due to the efficiency of said campaign, especially in the correct understanding of its target audience (Youtube generation) and the adoption of different types of marketing actions (widgets and ARG) which generated the necessary engagement for the film to get a good box office and serve as a starting point for the development of a franchise.
Power-effective thermoelectric semiconductor heat rejection for computer processors
Authors: Ismailov T. A. , Gadjiev H. M. , Ibragimova A. M.
Published: November 2020

Objective. The article deals with heat removal from computer processors in order to provide the necessary thermal conditions and temperature control of heat-generating components on integrated circuits.Methods. Methods for modeling heat exchange processes during heat transfer from a heated integral crystal to the environment are applied.Results. The power efficiency of heat rejection processors increases when using radiating thermoelectric semiconductor devices since heat is absorbed in some junctions, and instead of generating heat photons of the ultraviolet range are emitted to obtain better energy characteristics to ensure the necessary power removal from the heatgenerating components of radio-electronic circuits. This approach has a significant advantage as radiation has the maximum speed when transferring energy compared to convection and conduction, which allows for non-inertial heat removal from heat-generating components to the environment. This approach also allows increasing the efficiency of the cooling system and accelerating the transfer of heat from the heated areas to prevent heat breakdown.Conclusion. The conducted research allows concluding that light-emitting thermoelectric semiconductor devices can be used for cooling with high power efficiency, which can transfer large amounts of power to the environment with low inertia. An innovative cooling system for computer processors allows increasing the degree of integration by several orders of magnitude, which will increase the performance of computers and their speed.
Stable descriptors in image recognition tasks
Authors: Melekhin V. B. , Khachumov V. M.
Published: November 2020

Objective. The objective of the study is to determine various stable characteristics of images (semi-invariants and invariants) as descriptors necessary for the formation of a feature space of standards intended for recognizing images of different nature belonging to different classes of objects. Methods. The authors propose metrics for evaluating the proximity of the recognized image to a given standard in the space of covariance matrices, based on the obtained descriptors as a methodological basis for constructing image recognition methods. Results. The content of the main stages of selecting descriptors for a given class of objects is developed, taking into account the different illumination of the recognized images. The effectiveness of the results obtained is confirmed by experimental studies related to the solution of the problem of recognition of special images - facies. Conclusions. The definition of stable image descriptors as invariants or semi-invariants to zoom and brightness transformations allows solving the problems of facies classification in conditions of the unstable shooting of recognized images. The images can be rotated and shifted in any way. In general, the proposed approach allows developing an effective image recognition system in the presence of various types of interference on the recognized images.
Micro-Archives and the Survival of Print in Momma Tried and Sabat
Authors: Fazli Sabina
Published: November 2020

This article focuses on two independently published magazine projects, Sabat (2016–) and Momma Tried (2013–). It introduces Sabat and Momma Tried in the context of the contemporary independent publishing boom and considers their engagement with the print magazine form as affording a micro-archival stance towards the near past and personal histories as well as the magazines’ experiments with their material form.London-based Sabat appropriates the look and formula of women’s fashion and lifestyle magazines but reworks these templates to create a ‘lifestyle magazine for witches’ in a polished minimalist design. In three themed issues, Sabat establishes a meta-narrative of its own death which issue four materially enacts. Momma Tried is rooted in the art scene of New Orleans and started out as a celebration and record of the local community of creatives before the third issue turns the magazine into a ‘cyborg’ combining the print object with an app to create an ‘installation’. Both magazines evoke print as a way of conserving and archiving a specific moment but also engage in experiments that dissolve the magazine form, undermining its archiving function by staging the magazines’ ‘deaths’ as transformations.
Romance in Woman’s Weekly and Woman’s Weekly as Romance, 1918–39
Authors: Reed Eleanor
Published: November 2020

This article examines romance and social aspiration in British domestic magazine Woman’s Weekly during the interwar period. Between 1918 and 1939, Cinderella romance was the dominant fictional genre in Woman’s Weekly, which featured at least one complete story and one serial instalment in each weekly issue. These romances work through the social ambitions of the magazine’s target readers: lower-middle-class housewives on low incomes, who aspire towards class promotion. Assuming a social framework within which a woman’s status is determined by the status of her husband, and assuming a reading experience in which the heroine functions as the reader’s avatar, the social aspirations of Woman’s Weekly’s target readers emerge in the socio-economic status of the magazine’s fictional romance heroes. Surveyed using the ‘distant reading’ process pioneered by Franco Moretti, a sample of Woman’s Weekly Cinderella romances issued during 1918–19, 1928, and 1938–39 reveals shifts and complexities in these aspirations across the interwar period. Notably, these shifts and complexities reflect changes within Britain’s class system, and the assumed position of Woman’s Weekly’s target readers within it. Whilst Woman’s Weekly’s Cinderella romance fiction fulfils its target readers’ social aspirations in fantasy, the magazine’s lifestyle content promises to realize them in actuality, by supplying the products and behaviours associated with aspirational lifestyles. Showing how the anticipation and fulfilment of narrative resolution that underpins Cinderella romance narratives might shape one imaginary reader’s experience of reading Woman’s Weekly, I argue that it is the romantic promise of social elevation that attracts readers to the magazine, and ensures their long-term loyalty. The extent to which the magazine can fulfil this promise for real is, however, questionable.
Klinische aanpak van hypercalcemie bij de kat
Authors: Stock E. , Paepe D. , Daminet S.
Published: November 2020

Een verhoogde concentratie van totaal calcium is een onderkende afwijking op het bloedonderzoekvan de kat. De belangrijkste oorzaken van hypercalcemie bij de kat zijn neoplasie, chronischenierziekte en idiopathische hypercalcemie. Het diagnostisch onderzoek van een kat met persisterendehypercalcemie omvat verschillende stappen: een uitgebreid lichamelijk onderzoek, testen opfeliene leukemievirus en feliene immunodefi ciëntievirus, een volledig bloed- en urineonderzoek, hetbepalen van geïoniseerd calcium, radiografi eën van de thorax (en het abdomen), een echografi e vanhet abdomen en de hals en de bepaling van het parathyroïd hormoon en ‘parathyroid hormonerelatedprotein’. Een logische en specifi eke aanpak is nodig om tot een juiste diagnose te komen. Debehandeling richt zich vooral op de onderliggende oorzaak.
De monitoring van maagdarmworm- en leverbotinfecties op Belgische melkveebedrijven met tankmelk ELISA’s: maken we vooruitgang in parasietencontrole?
Authors: Charlier J. , Meyns T. , Soenen K. , Vercruysse J.
Published: November 2020

Infecties met maagdarmnematoden en leverbot (Fasciola hepatica) zijn een belangrijke oorzaakvan verminderde productiviteit bij herkauwers. In dit artikel worden de resultaten samengevat van een monitoringcampagne van helminthinfecties op Belgische melkveebedrijven. In het najaar van 2009 tot en met 2011 werden tankmelkstalen verzameld en onderzocht aan de hand van antistof-ELISA’s voorhet bepalen van de mate van blootstelling van de melkveebedrijven aan maagdarmwormen en leverbot. Het aantal deelnemende bedrijven in de campagne steeg van 1216 in 2009 tot 1731 in 2011. Het aantal bedrijven met een hoge mate van blootstelling aan maagdarmwormen vertoonde een significante variatie tussen de jaren en bedroeg 67%, 70% en 63% in de drie opeenvolgende jaren. Het aantal bedrijven meteen hoge mate van blootstelling aan F. hepatica bleef stabiel rond 30%. Er waren aanzienlijke regionale verschillen in de resultaten. De mate van blootstelling aan maagdarmwormen vertoonde een duidelijke toename van het noorden naar het zuiden van het land. De distributie van F. hepatica was geconcentreerd in de provincie West-Vlaanderen, het zuidelijke gedeelte van Oost-Vlaanderen, Henegouwen en het noordelijke gedeelte van Luxemburg. Wanneer de resultaten van deze campagne vergeleken worden met de resultaten van soortgelijke enquêtes in de omliggende landen, kan besloten worden dat de Belgische melkveebedrijven een hoge mate van blootstelling aan maagdarmwormen vertonen. Als men deze mate van blootstelling wil verlagen, moeten waarschijnlijk aanpassingen in het weidebeheer doorgevoerd worden en meer gebruik gemaakt worden van preventieve ontwormingsschema’s.
Voortplanting bij de Engelse buldog: een enquête bij fokkers
Authors: Wydooghe E. , Berghmans E. , Rijsselaere T. , Van Soom A.
Published: November 2020

Dystokie is een probleem bij alle hondenrassen, maar bij de Engelse buldog is het risico hoger omwille van zijn bijzondere conformatie en specifieke problemen zoals waterpups. In deze studie werd de frequentie van abnormale pups en voortplantingsproblemen onderzocht bij de Engelse buldog met behulp van een enquête bij 39 teven. Bij 74,4% van deze teven werd kunstmatige inseminatie uitgevoerd. Bij 25,8% van de teven werden ademhalingsproblemen en anorexia waargenomen aan het eind van de dracht. De dracht duurde gemiddeld slechts 58,7 dagen vanaf de eerste dekking. In 94,8% van de bevallingen werd een keizersnede uitgevoerd, spontane geboorte kwam slechts bij 5,2% voor. De gemiddelde nestgrootte in deze studie was zes pups. Dertien percent van de pups werd dood geboren, 8,2% van de levende pups had een afwijking waarbij palatoschisis (38,8%) en waterpups (27,7%) het meeste voorkwamen. Tien percent van de pups stierf vóór de speenleeftijd.
“Pituitary pars intermedia dysfunction” bij het paard: belangrijke aandachtspunten en recente ontwikkelingen
Authors: Broux B. , Lefère L. , van Loon G.
Published: November 2020

“Pituitary pars intermedia dysfunction” (PPID), vroeger vooral bekend onder de naam “Cushing’s disease”, is een veel voorkomende aandoening bij oudere paarden. Omdat het aantal oudere paarden de laatste decennia stijgt, wordt ook PPID steeds vaker gediagnosticeerd. Recent onderzoek heeft geleid tot nieuwe inzichten in het ontstaan van de ziekte en een verbetering van diagnostische testen en behandelingsmogelijkheden. Dit artikel beschrijft de pathofysiologie en de klinische symptomen, evenals de recentste ontwikkelingen betreffende de diagnose en behandeling van PPID.
Chirurgische excisie van een branchiale cyste bij een hond
Authors: Dhont J. , Furcas A. , Vandervekens E. , Polis I. , de Rooster H.
Published: November 2020

Een zes jaar oude, vrouwelijke, gecastreerde cavalier king charles werd aangeboden voor verderonderzoek en behandeling van een recidiverende zwelling ter hoogte van de linkerkaakregio. Opbasis van een klinisch en echografi sch onderzoek werd de waarschijnlijkheidsdiagnose van eensialocele van de linkerparotisspeekselklier gesteld. Er werd besloten tot chirurgische excisie van despeekselklier. Tijdens de chirurgie werd een cysteus proces van de parotisspeekselklier, verbondenmet een meer ventraal gelegen cyste, gevisualiseerd. Zowel de parotisspeekselklier als de ventralecyste werd vrijgeprepareerd en verwijderd. Op basis van een histopathologisch onderzoek vanhet verwijderde weefsel werd de diagnose van een branchiale cyste gesteld. Afgezien van eengedeeltelijke facialisparalyse de eerste dag postoperatief, verliep het herstel vlot. Tot op heden,inmiddels meer dan een jaar postoperatief, werd geen recidief vastgesteld.