bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Clinical Characteristics of 145 MGTB patients in three provincial teaching hospitals in Gansu province
Authors: Guo Chenhao , Zhang Jing , Zhang Yongjuan , Jiang Nan , Zhang Ke , Tian Yixin , Yang Meiling , Ma Lilong , Huang Xueyi , Li Weiping , Huang Xiande , Shang Panfeng
Published: October 2024

Objective
To explore the strengths and weaknesses of current diagnostic and therapeutic approaches for MGTB.
Methods
The clinical data of 145 patients diagnosed with MGTB from January 2013 to September 2023 were retrospectively analyzed to determine better diagnosis and treatment methods to guide clinical practice.
Results
Among 145 male patients with MGTB, 29 (20%) were accompanied by urinary TB, and 116 (80%) were only associated with MGTB. TSPOT and ultrasound are the most valuable laboratory and imaging methods. Surgical resection was still the first choice for the cure of germline tuberculosis, 113 patients chose surgical resection, the resection rate was 77.93%, the cure rate was 75%, and the recurrence and progression rate were 5.36%. The symptoms of MGTB are insidious, and the accurate diagnosis requires a combination of laboratory tests and imaging examinations. TSPOT and ultrasound are the most valuable diagnostic methods and are recommended as the first choice.
Conclusion
Preoperative and postoperative anti-tuberculosis drug therapy is necessary to reduce the incidence of complications and the risk of recurrence. When treating germline tuberculosis, we should pay attention to the patient's sexual function and fertility.
Bowel Perforation in neonates with Hirschsprung's disease
Authors: Liu Zhaozhou , Zhang Yanan , Sun Dayan , Chen Yongwei , Guo Weihong , Du Jingbin , Huang# Jinshi
Published: October 2024

Background
Bowel perforation is a severe complication of Hirschsprung's disease (HD) that necessitates prompt diagnosis and aggressive management to reduce mortality and morbidity. This study aimed to provide insights into the clinical management of neonatal HD cases complicated by bowel perforation.
Methods
A retrospective review was conducted on neonates diagnosed with HD and bowel perforation at Beijing Children’s Hospital from January 2007 to January 2024. Inclusion criteria included neonates ≤ 28 days old with confirmed HD diagnosis based on postoperative histology. Data collected included perinatal history, patient characteristics, HD classification, clinical presentations, surgical interventions, and outcomes. Statistical analysis was performed using SPSS 26.0.
Results
Among 300 neonates diagnosed with HD, 18 (6.0%) developed preoperative bowel perforation. Most perforations were in the proximal ganglionic bowel, with short-segment HD (7/18, 38.9%) and long-segment HD (9/18, 50.0%) being most common. All patients underwent surgery within 24 hours of perforation detection, with 94.4% (17/18) requiring stoma creation. Postoperative complications included stoma retraction, Hirschsprung disease-associated enterocolitis, and adhesive bowel obstruction, but no mortality was reported.
Conclusion
The incidence of preoperative bowel perforation in neonates with HD was 6.0%, primarily in cases of short-segment and long-segment HD. Perforations were mainly located in the proximal ganglionic segments. Prompt surgical intervention, particularly stoma creation, resulted in favorable outcomes for most patients.
Improving COVID-19 Mortality Predictions: A Stacking Ensemble Approach with Diverse Classifiers
Authors: Mohtasham Farideh , Pourhoseingholi MohamadAmin , Nazari Seyed Saeed Hashemi , Kavousi Kaveh , Zali Mohammad Reza
Published: October 2024

Ensemble approaches are vital for developing effective machine learning methods by integrating multiple models to enhance performance and reduce bias and variance. This study utilized ensemble techniques to predict COVID-19 mortality using various classifiers. We first mapped the original dataset to a lower-dimensional space to improve training diversity. We then trained multiple base classifiers and ensemble methods, assessing their diversity through pairwise evaluations to create diverse combinations. A Stacking ensemble method was implemented with different meta-learners for improved predictive performance. All models were rigorously evaluated using standard discrimination and calibration metrics, along with statistical tests to identify significant performance differences. Various feature importance methods were applied to clarify the contributors to our model's predictions. The experimental results demonstrated the superiority of our stacking framework, specifically combining Random Forest and Extreme Gradient Boosting (XGBoost) with a Neural Network as the meta-learner on COVID-19 mortality prediction. This model achieved an accuracy of 0.914 (95% CI: 0.898, 0.928), precision of 0.818, F1-score of 0.801, Matthew’s correlation coefficient (MCC) of 0.746, and a ROC AUC of 0.955. These findings indicate that our framework is more effective than individual classifiers and existing ensemble methods, providing valuable insights for medical decision-making.
Climate-driven introduction of an opportunistic symbiont in the most extensive reef system of the Southwestern Atlantic Ocean
Authors: Vilella Livia B. , Aiube Yuri R. , Silva-Lima Arthur W. , Moura Rodrigo L. , Salomon Paulo S.
Published: October 2024

Coral symbionts of the Symbiodiniaceae family range from strictly mutualistic to highly opportunistic species. Symbiodinium necroappetens is an opportunistic species and a putative necrophile of dead coral tissue, hitherto reported as endemic to the Caribbean. Symbiodiniaceae were characterized by ITS2 barcoding along the most severe thermal anomaly registered in the Abrolhos Bank, southwestern Atlantic Ocean (SWAO). S. necroappetens relative abundance and prevalence went from undetectable before the anomaly to as much as 73% and 100%, respectively, during and after the heatwave. Sequences were still detectable four years after being initially observed. We are likely observing a climate-driven introduction of S. necroappetens in the SWAO. Given the increasing frequency and intensity of thermal anomalies hitting the global ocean, we can only speculate on the ecological consequences of such invasion for the Abrolhos reefs.
Based on the local image of the visual involute gear pitch measurement method
Authors: Zhi Shan , Ji Changli , Wang Zihao , Du Po
Published: October 2024

This paper aims to rapidly measure the small and medium module spur gear pitch in industry and solve the complex problem of visual measurement. It proposes an algorithm for a single-gear pitch based on the statistical information of the tooth profile image edge’s transition zone. Firstly, the local image of the involute gear was processed; Then, based on the geometric characteristics of the involute tooth profile edge, a pixel point parameter database has been established, the transition zone's pixel information is inversely mapped to the base circle to calculate the initial phase angle of the tooth profile edge involute. Finally, the gear pitch is calculated by using the initial phase angles of two adjacent tooth profiles with the same name. In addition, through theoretical analysis and simulation calculation, the sine curve model of the initial phase Angle error of the tooth profile caused by the eccentricity of the base circle positioning is obtained. The results show that: 1.When the eccentricity e ≤ 40 µm, when the positioning error Δψj ≤ 1°, it can meet the measurement requirements of 5-level precision gear; 2. Measuring the pitch of the same 5th-grade precision gear, the difference between the two pitches measured by the visual gear measuring instrument and the Coordinate Measuring Machine is 0.4 µm and 0.2 µm, respectively; 3. The maximum single-pitch deviation of the visual gear measuring instrument and the M&M3525 gear measuring center is on the same pitch. The difference between the two is 0.7 µm, and the total deviation of the pitch accumulation is 3.3 µm. It indicates that this gear pitch visual measurement method can meet the rapid measurement requirements of the 5th-grade precision spur gear pitch.
Research on Mathematical Model of Rolling Force for Asymmetrical Rolling of Cu/Al Clad Plate
Authors: Chen Suwen , Ding Wenjie , Zhang Zhiquan , Sun Jianliang , Gu Dapeng
Published: October 2024

Based on the principal stress method, the mathematical model of rolling force for asymmetrical rolling of Cu/Al clad sheet is established.The lengths of different deformation intervals are solved based on the geometric relationship and the deformation characteristics of clad shee. The stress of differential element in different deformation zones is analyzed, combined with the equilibrium differential equation, geometric relationship of deformation zones, boundary conditions and yield criterion, and the rolling pressure in different deformation zones is solved. According to the calculation results, the influence law of process parameters on rolling force, neutral point position and cross-shear zone length is analyzed, which provides a theoretical basis for further research on rolling process.
How cultural and creative tourism product design affects the psychological generation of cultural confidence：evidence from the Three Gorges Museum in China
Authors: Xia Jinjun , Li Yashi , He Yuanheng
Published: October 2024

Cultural confidence is a critical social psychological phenomenon with respect to efforts to promote cultural development, social harmony, and personal spiritual growth. Advances in economic development and improved living standards lead to increased demand for cultural and creative tourism products that offer humanistic experiences and spiritual fulfillment. An important task is thus to explore how the cultural creative tourism products design (CCTPD), which serve as crucial media for cultural dissemination, influence the psychological generation of cultural confidence. The CCTPD items was classified into five dimensions based on the strategic experiential model (SEMs): SENSE, FEEL, ACT, THINK, and RELATE. This study investigated the Cultural and Creative Experience Pavilion at the Three Gorges Museum in Chongqing, China, using 321 responses collected via a field survey. Structural equation modelling (SEM) was employed to investigate the mechanism underlying the psychological generation of cultural confidence and the specific impacts of CCTPD on this mechanism. The results indicated that the psychological generation of cultural confidence is characterized by a sequential progression from cultural cognition to cultural identity and, ultimately, to cultural confidence. As a cultural carrier, CCTPD significantly influences each stage of this process and has the strongest impacts on cultural cognition. Furthermore, different dimensions of CCTPD affect the stages of the process by which cultural confidence is generated in different ways. Specifically, sense experience, act experience, and think experience significantly affect cultural cognition; think experience and relate experience significantly affect cultural identity; and sense experience, relate experience, and feel experience significantly influence cultural confidence. The findings of this research provide insight for both cultural psychology and design studies, and can serve as a reference for policy-makers to promote cultural confidence and designers in implement targeted practices.
Aging and semantic transparency effects during Chinese reading: Evidence from eye movements
Authors: Cao Xuran , Du Yaxin , Wang Jingxin
Published: October 2024

Background
Semantic transparency of radicals is the degree to which constituent radicals are semantically related to the meaning of a whole character. Semantic transparency is important in compound words processing. Previous studies mostly used priming paradigm to examine semantic transparency effects on young adults. However, considering that vision typically changes with age, it is important to establish whether semantic transparency effects are equivalent across adulthood.
Methods
Young (18–25 years) and older (65 + years) adults were recorded while reading sentences with transparent and opaque target words. In Experiment 1, these target words were present throughout reading. In contrast, Experiment 2 used a gaze-contingent paradigm.
Results
Both groups showed greater difficulty processing opaque words than transparent words. In Experiment 1, however, there were no interactions, confirming that semantic transparency effects are similar for both age groups. In Experiment 2, semantic transparency effects were greater for older adults. Therefore, opaque words are more difficult to process than transparent words.
Conclusions
Semantic transparency effects are not significantly moderated by age during normal reading, although the interaction effects in Experiment 2 suggests that older adults rely on character-based reading strategies to compensate for decreased parafoveal processing abilities, as lexical representation is especially important for transparent words processing.
Pyrophosphate-Free Glycolysis in Clostridium thermocellum Increases Both Thermodynamic Driving Force and Ethanol Titers
Authors: Sharma Bishal Dev , Hon Shuen , Thusoo Eashant , Stevenson David M. , Amador-Noguez Daniel , Guss Adam M. , Lynd Lee R. , Olson Daniel G.
Published: October 2024

Background
Clostridium thermocellum is a promising candidate for production of cellulosic biofuels, however its final product titer is too low for commercial application, and this may be due to thermodynamic limitations in glycolysis. Previous studies in this organism have revealed a metabolic bottleneck at the phosphofructokinase (PFK) reaction in glycolysis. In the wild type organism, this reaction uses pyrophosphate (PPi) as an energy cofactor, which is thermodynamically less favorable compared reactions that use ATP as a cofactor. Previously we showed that replacing the PPi-linked PFK reaction with an ATP-linked reaction increased the thermodynamic driving force of glycolysis, but only had a local effect on intracellular metabolite concentrations, and did not affect final ethanol titer.
Results
In this study, we substituted PPi-pfk with ATP-pfk, deleted the other PPi-requiring glycolytic gene pyruvate:phosphate dikinase (ppdk), and expressed a soluble pyrophosphatase (PPase) and pyruvate kinase (pyk) genes to engineer PPi-free glycolysis in C. thermocellum. We demonstrated a decrease in the reversibility of the PFK reaction, higher levels of lower glycolysis metabolites, and an increase in ethanol titer by an average of 38% (from 15.1 g/L to 21.0 g/L) by using PPi-free glycolysis.
Conclusions
By engineering PPi-free glycolysis in C. thermocellum, we achieved an increase in ethanol production. These results demonstrate that optimizing the thermodynamic landscape through metabolic engineering can enhance product titers. While further increases in ethanol titers are necessary for commercial application, this work represents a significant step toward engineering glycolysis in C. thermocellum to increase ethanol titers.
Data verification protocol for a confidential computing scheme with homomorphic encryption
Authors:   Department of Software Engineering and Artificial Intelligence, Far Eastern Federal University (FEFU), Bystrevskii Sergey A. , Borshevnikov Aleksei E. ,   Department of Information Security, Far Eastern Federal University (FEFU), Dobrzhinsky Yuri V. ,   Department of Information Security, Far Eastern Federal University (FEFU)
Published: October 2024

Auction trading systems and Big Data technologies play an important role in modern society. However, as soon as these technologies deal with the finances of their users, there is a need to implement security systems in them to ensure the possibility of data verification. The article proposes a data verification protocol based on the use of homomorphic encryption. A formal safety assessment of the developed protocol is shown, and an analysis from a probabilistic standpoint is carried out.
Crosstalk suppression system in multi-wire communication lines with signal encoding and decoding
Authors:   Federal State Autonomous Educational Institution of Higher Education ", Fedorov V. N. ,   M. K. Ammosov North-Eastern Federal University"
Published: October 2024

It is proved that the transmission matrix of any multi-wire communication line can be represented as a product of three matrices: transverse wave mode converter, uncoupled transmission lines, and inverse matrix of the transverse wave mode converter. The analysis showed that the matrix of the transverse wave mode converter is an M-matrix or a Hadamard matrix. This made it possible to generalize the methods of crosstalk suppression and the methods of encoding and decoding signals by connecting a multi-wire communication line to sources/receivers through an electromagnetic wave mode converter, implemented, for example, on transformers. As a result, each subscriber transmits/receives signals only on its own mode type. This ensures reliable data transmission and protection from crosstalk. The devices of mode converters are described; calculations and experimental results for symmetrical multi-wire communication lines are given.
INTEGRATING ENVIRONMENTAL MANAGEMENT AND INDUSTRIAL ECOLOGY: APPROACHES, TOOLS, AND MODELS FOR SUSTAINABLE DEVELOPMENT
Authors:   School of Economics and Management, Anhui University of Science and Technology, Huainan 232001, China., Haloui Ismail , Yang Li ,   School of Economics and Management, Anhui University of Science and Technology, Huainan 232001, China.
Published: October 2024

The environment encompasses all living and non-living factors influencing an organism, essential for the existence and health of life on Earth. Environmental science and engineering address the interactions between human systems and natural systems, emphasizing the need for sustainable practices to mitigate environmental degradation caused by human activities. This paper explores two primary approaches for environmental protection: Environmental Management and Industrial Ecology. Environmental Management involves strategies like resource optimization, sustainable development, and disaster risk reduction, employing models such as terminal control and pollution prevention. Industrial Ecology focuses on creating industrial ecosystems that mimic natural processes, aiming to minimize waste and optimize resource use. Tools supporting these approaches include Life Cycle Assessment and Design for Environment, which assess and reduce the environmental impacts of products and processes throughout their lifecycle. By integrating these methods, we can enhance environmental protection, improve resource efficiency, and promote sustainable industrial practices.
RENEWABLE ENERGY IN THE KINGDOM OF MOROCCO: EXPLORING THE IMPACT OF TECHNOLOGICAL INNOVATIONS ON CARBON DIOXIDE EMISSIONS
Authors:   School of Economics and Management, Anhui University of Science and Technology, Huainan 232001, China., Haloui Ismail , Yang Li ,   School of Economics and Management, Anhui University of Science and Technology, Huainan 232001, China., Haloui Siham ,   School of Economics and Management, Anhui University of Science and Technology, Huainan 232001, China.
Published: October 2024

Morocco is aligning with the global shift towards renewable energy, strategically investing in locally available sources to enhance economic independence and sustainable development. This study investigates the pressing issue of carbon emissions, examining the interplay between renewable energy sources, information and communication technology (ICT), governance, and GDP in Morocco through a time-series analysis using the ARDL model. The results underscore the pivotal role of renewable energy (solar, wind, hydroelectric), ICT, and effective governance as key factors in curbing carbon emissions. The findings have far-reaching implications for long-term carbon emission reduction and inform Moroccos policy framework in the fight against climate change.
O USO DOS BLOQUEADORES NEUROMUSCULARES E AS AÇÕES DE ENFERMAGEM
Authors: Bárbara de Castro Oliveira Barbosa  , Flávia dos Santos Lugão de Souza  , Roberta Mendes Von Randow
Published: October 2024

O presente estudo tem como objetivo descrever as características dos bloqueadores, elucidar os principais diagnósticos de enfermagem e possíveis planos de cuidados para o paciente em uso de bloqueadores neuromusculares. Foram coletados artigos de 2013 a 2023 na Biblioteca Virtual em Saúde nos meses de maio a junho de 2023 tendo como resultado 14 artigos inerentes ao assunto que se encontraram pertencentes a linha do tempo escolhida. Os bloqueadores neuromusculares são medicamentos usados comumente na rotina de cuidados da Unidade de Terapia Intensiva, sendo utilizados em procedimentos como a intubação orotraqueal e na manutenção de sedação dos pacientes.  Assim, concluiu-se que os Bloqueadores Neuromusculares são medicamentos que se usados com cautela e parcimônia se mostram de grande ajuda no tanto no âmbito emergencial, como numa intubação orotraqueal como também podem ser utilizados para manutenção da sedação de pacientes.
Positive eWOM and Consumers with a Fear of Missing Out
Authors: Putri Ni Luh Debby Maharani Eka , Sulhaini Sulhaini , Saufi Akhmad
Published: October 2024

The study aims at examing the effect of positive electronic word of mouth (eWOM) and consumers with Fear Of Missing Out (FOMO) of local skincare products. This research is quantitative in nature. the population are Indonesians who have shopped for local skincare products through s-commerce applications. the number of samples were 150. The data analysis is Structural Equation Modeling (SEM) approach, especially Partial Least Square (PLS) method.  The results showed that positive eWOM had no significant effect on impulse buying, while price discount showed the opposite. The study also found that  FOMO strengthens the effect of eWOM on impulse buying, suggesting that if the fear of missing out is high, positive eWOM prompts consumers to buy products impulsively.
The Role of CEO Altruism in Moderating the Relationship between Affective Commitment and Integrity with OCB in Culinary SMES
Authors: Siddiq Dedi , Mukhibulloh Mukhibulloh , Dewi Annah , Astuti Ramlah , Alang Tho
Published: October 2024

This research aims to examine the relationship between chief executive officer (CEO) altruism, affective commitment, integrity and organizational citizenship behavior (OCB). More specifically, this research examines the extent to which the role of CEO altruism plays in moderating the relationship between employee affective commitment and integrity towards employee OCB of small and medium businesses in the culinary sector in Indonesia. This research uses quantitative approach and data were collected through paper-based survey. Data analysis uses multiple regression and moderated regression analysis with a significant level of 0.05 to test the hypothesis. The research found that employee affective commitment and integrity have a positive effect on OCB. In addition, CEO altruism plays a significant role as a moderating variable in strengthening the relationship between employee affective commitment and OCB and also strengthening the relationship between employee integrity and OCB. These findings provide important insights for SME managers to demonstrate altruism towards their employees so as to increase employee OCB.
Genre of Life in the Works by Epiphanius the Wise
Authors:   Vyatka State University, Zlobin Andrei A.
Published: October 2024

This article is devoted to the study of the originality of the hagiographic genre in the work of the outstanding writer of the 14th–15th centuries, the Reverend Epiphanius the Wise. The specifics and structure of hagiographic texts are studied, their classification is presented, the connection of the original Old Russian works with the Byzantine hagiographic canon is emphasized. According to the author of the article, the hagiographic genre reaches its peak in its development in the era of the formation of a centralized Russian state. Epiphanius the Wise, a recognized master of his times, creating hagiobiographies of St. Stephen of Perm (the saintly type of life) and Sergius, abbot of Radonezh (the reverend type of life), relies on early Byzantine and medieval Russian traditions and creates a new stylistic principle, which was called “weaving of words”: synonymous series of epithets, lexical repetitions, anaphors, techniques homeotelevton, homeoptoton, text rhythmization, etc. It is thanks to the new manner of narration that, for the first time in Russian literature, the possibility of fixing the inner life of Orthodox ascetics and studying their spiritual experience opens up. The author of the article, analyzing the “Life of Stephen of Perm” and “Life of Sergius of Radonezh”, created by Epiphany the Wise, actualizes their significance in the formation of the phenomenon of holiness and comes to the conclusion that these hagiographic works are closely related to the main line of Russian literature of the 19th and 20th centuries, associated with attention to the inner world of man, his spiritual quest and spiritual experiences. The author suggests including the texts of Epiphanius the Wise in the list of additional literature for schoolchildren, justifying this by the fact that familiarity with the works of the outstanding scribe will prepare students for thoughtful reading and deeper understanding of the novels of Russian writers of the 19th and 20th centuries.
The Whole Life is a Theater! Reception of Russian Literature in the Minds of Foreign Citizens Through Classes in a Theater Studio (in the Program of the Preparatory Faculty)
Authors:   Belgorod State Technological University named after V. G. Shukhov, Akifi Olesya I. , Legochkina Elena N. ,   Belgorod State Technological University named after V. G. Shukhov, Kuzkina Alina I. ,   Belgorod State Technological University named after V. G. Shukhov
Published: October 2024

The purpose of the proposed research is to substantiate the relevance and necessity of introducing elements of theatricalization (in the form of a theater studio) into the main program of the preparatory faculty for foreign citizens in order to increase motivation for learning the Russian language and Russian culture, as well as the formation of a secondary linguistic personality. The real practical long-term experience of using different types of theatricalization and the stages of formation of a theater studio at the preparatory faculty were used as research materials. The methodological basis is the materials of scholarly research of colleagues, methods of analysis and comparison of the results of mastering the Russian language. During the practical experiment, the research methods of analytical generalization of the results, the method of practical modeling, the method of abstraction, observation, and the study of the products of listeners’ creative work were used in order to identify progress (or its lack) in the assimilation of the Russian language and the implementation of the reception. Education is one of the powerful levers of the “soft power” policy, and therefore it is important to find new effective and interesting types of classes. Russian language and culture studies are supported by the addition of optional courses to the standard program that take into account the interests of foreign citizens. Russian literature reception plays an important role in the formation of a common cultural background, as well as forms an understanding of the Russian character, which is important for a better socio-cultural adaptation.
Homocysteine Blood Levels and Mandatory Folic Acid Fortification in Serbia
Authors: Vasiljevic Zorana , Zlatic Natasa , Rajic Dubravka , Mitrovic Predrag , Viduljevic Mihajlo , Matic Dragan , Asanin Milika , Stankovic Sanja
Published: October 2024

Introduction:

The current study aims to investigate the blood Hcy levels in patients with CAD and
hypertension in Serbia, a country with a high incidence and mortality of both diseases

Methods:

The level of Hcy in the Serbian population was assessed in 123 patients with chronic coronary
artery disease (CAD) and hypertension. There were 53 patients with chronic CAD and 70 patients with hypertension
(HTA), but without CAD.

Results:

The Hcy levels were high in both groups of patients (the mean Hcy level of 16.0 ± 7.0 μmol/L) without
a statistical difference between the patients in the CAD (14.9 ± 7.3 μmol/L) and hypertension (16.7 ± 6.7
μmol/L) groups. Hypercholesterolemia was found in 81% of the patients with CAD and 92.0% of the patients
with HTA, as a common concern across both clinical conditions. It was also found that not a single conventional
risk factor (diabetes, hypertension, the smoking status, the family history of CAD, and hyperlipidemia) may
individually influence Hcy levels. By contrast, the low levels of vitamin B12 may be related to the high levels
of Hcy.

Conclusion:

Given the fact that it is known that various factors interact and influence Hcy levels and associated
cardiovascular risks, specific dietary habits, lifestyle and the other Serbia-specific possible factors were
done.
Dihydroartemisinin Modulates Prostate Cancer Progression by Regulating Multiple Genes via the Transcription Factor NR2F2
Authors: Shao Yong , Chan Yunhui , Zhang Chuan , Zhao Rong , Zu Yuxin
Published: October 2024

Objective:

This study aimed to investigate the effect of dihydroartemisinin (DHA) on
DU145 cells and the role of NR2F2 (COUP-TFII) and its potential target genes in this process.

Methods:

GSE122625 was used to identify differentially expressed genes (DEGs) between the
DHA-treated and control groups. Protein-protein interaction (PPI) network analysis was performed
to identify hub genes, and the ChEA3 database was used to identify potential transcription
factors. qRT-PCR and Western blot were used to validate the expression of genes of interest
and functional assays were performed to evaluate the effect of DHA on DU145 and PC-3 cells.
To solidify the regulatory relationship of NR2F2 with EFNB2, EBF1, ETS1, and VEGFA, a
Chromatin Immunoprecipitation (ChIP) experiment was performed.

Results:

We identified 85 DEGs in DU145 cells treated with DHA, and PPI network analysis
identified NR2F2 as a hub gene and potential transcription factor. The regulatory network of
NR2F2 and its potential target genes (EFNB2, EBF1, ETS1, and VEGFA) was constructed, and
the expression of these genes was upregulated in DHA-treated cells compared to control cells.
Functional assays showed that DHA treatment inhibited epithelial-mesenchymal transition, reduced
inflammation, and promoted apoptosis in DU145 and PC-3 cells. Furthermore, NR2F2
knockdown receded the DHA-induced upregulation of target genes and functional changes of
DU145 and PC-3 cells. The outcomes of ChIP unequivocally pointed to a positive regulatory
role of NR2F2 in these gene expressions.

Conclusion:

Our study suggests that DHA treatment affects the functions of DU145 and PC-3
cells by regulating the expression of NR2F2 and its potential target genes, and NR2F2 may serve
as a potential therapeutic target for prostate cancer.

result:

We identified 85 DEGs in DU145 cells treated with DHA, and PPI network analysis identified NR2F2 as a hub gene and potential transcription factor. The regulatory network of NR2F2 and its potential target genes (EFNB2, EBF1, ETS1, and VEGFA) was constructed, and the expression of these genes was found to be upregulated in DHA-treated cells compared to control cells. Functional assays showed that DHA treatment inhibited epithelial-mesenchymal transition, reduced inflammation, and promoted apoptosis in DU145 and PC-3 cells. Furthermore, NR2F2 knockdown receded the DHA-induced upregulation of target genes and functional changes of DU145 and PC-3 cells. ChIP’s outcomes unequivocally pointed to a positive regulatory role of NR2F2 in these gene expressions.
Identifying Prostaglandin D2 Synthase in Urine: A Potential Biomarker for Bladder Cancer
Authors: Tan Lia-Beng , Tyan Yu-Chang , Hsu Jen-Yi , Hsen Kun-Hung , Liao Pao-Chi , Guo How-Ran
Published: October 2024

Introduction:

Proteins present in body fluids harbor the potential to act as markers for
both diagnosing diseases and exploring their underlying mechanisms. As urine can be easily obtained
non-invasively, analyzing its proteins is an ideal approach to identifying biomarkers for
bladder cancer. This study aimed to identify proteins in urine that could serve as biomarkers for
bladder cancer.

Method:

Urine samples were collected from patients with primary transitional cell carcinoma of
the bladder and their age and sex-matched healthy individuals. The protein pellet underwent resolubilization
and trypsin digestion to facilitate analysis using reverse phase nano-high performance
liquid chromatography/electrospray ionization tandem mass spectrometry.

Result:

In samples obtained from 16 patients and 8 controls, 3192 peptides were identified, corresponding
to 934 unique proteins, of which 60 were identified with higher confidence levels.
Among them, Transferrin and Prostaglandin D2 Synthase (PTGDS) were found as potential markers
of bladder cancer. In particular, the absence of PTGDS has a specificity of 100% and a sensitivity
of 81%.

Conclusion:

This study, which used proteomic approaches, identified PTGDS in urine as a potential
biomarker of bladder cancer.
Design, Synthesis, Biological Evaluation, Molecular Docking, and Molecular Dynamics Simulation Studies of Fmoc-L-Lysine Carboxamides as Promising Cytotoxic Agents
Authors: Parepalli Mahalakshmi C.S. , Galla Rajitha
Published: October 2024

Background:

Despite advancements in treatment modalities, the search for new cytotoxic
agents remains vital in the fight against cancer. This ongoing effort aims to introduce novel molecules
that serve as potent cytotoxic agents while minimizing adverse effects.

Objective:

The objective of the study is to design, synthesize, and evaluate Fmoc-L-Lysine Carboxamides
for cytotoxic activities.

Methods:

The title compounds 4a-l were synthesized by esterification followed by reduction of
Fmoc-Lys (Boc)-OH to alcohol, then coupled with various aryl/alkyl/alicyclic carboxylic acids. These
compounds were then analysed using 13C NMR, 1H NMR, FT-IR, and Mass spectroscopic techniques
and evaluated for cytotoxic activity by MTT assay, apoptosis induction, cell cycle analysis,
EGFR-TK inhibition activity, molecular docking, and molecular dynamics simulation studies.

Results:

The results obtained by MTT assay indicated that compounds 4f and 4i demonstrated significant
cytotoxicity against A549 and SKOV3 cell lines, with IC50 values of 2.75 and 1.91μM compared
to doxorubicin. Further, the analysis of the Cell cycle and apoptosis proposed that 4f arrested
the cell cycle in the G0/G1 phase, whereas 4i arrested the cell cycle in the G2/M phase and triggered
apoptosis in cancer cells. Notably, compound 4i demonstrated the highest inhibition of EGFR with
IC50, 0.189μM, and acted as its potential inhibitor. Molecular docking and dynamics simulation studies
further confirmed the stability of 4i in the active site of EGFR.

Conclusion:

Overall, these results suggested that the synthesized derivatives offer a promising approach
for the advancement of new and effective cancer therapies.
Emerging Claudin18.2-targeting Therapy for Systemic Treatment of Gastric Cancer: Seeking Nobility Amidst Danger
Authors: Ye Xueshuai , Wu Yongqiang , Zhang Haiqiang
Published: October 2024

Gastric cancer in advanced stages lacked effective treatment options. claudin18.2 (CLDN18.2) is a
membrane protein that is crucial for close junctions in the differentiated epithelial cells of the gastric mucosa,
playing a vital role in barrier function, and can be hardly recognized by immune cells due to its polarity pattern.
As the polarity of gastric tumor cells changes, claudin18.2 is exposed on the cell surface, resulting in immune
system recognition, and making it an ideal target. In this review, we summarized the expression regulation mechanism
of claudin18.2 both in normal cells and malignant tumor cells. Besides, we analyzed the available clinical
results and potential areas for future research on claudin18.2-positive gastric cancer and claudin18.2-targeting
therapy. In conclusion, claudin18.2 is an ideal target for gastric cancer treatment, and the claudin18.2-targeting
therapy has changed the treatment pattern of gastric cancer.
Cross-River Transmission Corridor Scheme Evaluation Based on Hierarchical Analysis Method
Authors: Cai Chenlin , Tang Bo , Qi Daokun , Li Xianxin , Zhang Linfeng , Zhang Longbin
Published: October 2024

Background:

In order to solve the problems of single influencing factors and inconsistency
of subjective experience of multiple experts under different working conditions in the
evaluation of existing cross-river transmission corridor schemes, a cross-river transmission corridor
scheme evaluation method based on hierarchical analysis has been proposed in this work.

Method:

Firstly, six evaluation indices, including planning and important facility areas, environmentally
sensitive points, geological conditions, hydrological conditions, safety and economy,
have been established to construct a system for assessing the impact factors of cross-river transmission
corridors. Then, the hierarchical analysis method has been combined with the improved
grey correlation analysis to synthesize the weight judgement values of multiple experts, construct
a unified scoring system for the weights of qualitative and quantitative indexes, effectively improve
the stability of the indexes' weights, and realize the scientific assessment of the cross-river
transmission channel scheme. Finally, the engineering scheme of a cross-river transmission channel
has been evaluated.

Results:

Through practical engineering analysis, the selected cross-river transmission channel using
this method has been found to be consistent with the actual project.

Conclusion:

The results have shown that the method could effectively achieve the evaluation of
various cross-river transmission channel schemes by comprehensively considering a variety of
factors in the selection of cross-river corridors for transmission lines and effectively protecting the
empirical roles of different experts.
Optimizing Federated Reinforcement Learning Algorithm for Data Management of Distributed Energy Storage Network
Authors: Li Yuan , Li YuanCheng
Published: October 2024

Background:

The development of energy storage networks has facilitated the rapid
expansion of new energy-based power systems. However, the emergence of large-scale energy
storage devices has also led to a significant increase in energy data volumes. Federated learning
provides a solution by allowing energy data owners to train AI models without sharing local energy
data, which is particularly advantageous for handling heterogeneous data.

Objective:

This paper explores the application of federated learning in managing energy data within
distributed energy storage networks. Specifically, we leverage deep reinforcement learning algorithms
to optimize the selection of device subsets, aiming to mitigate data bias caused by nonidentically
and independently distributed (non-IID) data while enhancing convergence rates.

Method:

To achieve our objectives, we employ deep reinforcement learning to dynamically select
the optimal subset of devices in the federated learning process. Additionally, we introduce a reputation
replay array mechanism to address the issue of free-rider users and ensure fair modeling
without payment penalties. We analyze energy data characteristics within distributed energy storage
networks and simulate unstructured short data fragments using datasets such as 20 Newsgroups
and AG News.

Results:

Our experiments show that our proposed model outperforms FedAvg and TiFL on the 20
Newsgroups and AG News datasets, especially under non-iid conditions. Our model significantly
reduces communication rounds by up to 47% and 39%, respectively. It also maintains high accuracy
and resilience against dishonest nodes, ensuring the quality of the training model.

Conclusion:

Our research concludes that combining federated learning with deep reinforcement
learning not only solves the problems of data management and privacy protection in distributed
energy storage networks, but also promotes the sustainable development of new energy systems.
THE INFLUENCE OF LIVE STREAMING AND DISCOUNTS ON PURCHASE DECISIONS AT TIKTOK SHOP
Authors: Syarifah Azzahra Annisa , Citra Rahayu Indraswari
Published: October 2024

The purpose of this research is to find out how live streaming features and discounts influence TikTok Shop Generation Z consumers, who are domiciled in Jakarta and aged between 18 and 24 years in purchasing decisions. With a total of 270 respondents, this research uses quantitative methods, employing multiple linear regression analysis. The findings show that the live streaming features positively and significantly influence the purchasing decisions of TikTok Shop Generation Z consumers. Additionally, discounts also have a positive and significant influence on consumer purchasing decisions. Both live streaming features and discounts simultaneously influence the purchasing decisions of TikTok Shop Generation Z consumers in a positive and significant.
ANALISIS PENGARUH PEER-TO-PEER LENDING TERHADAP KINERJA KELOMPOK BANK DENGAN MODAL INDIKATOR KESEHATAN EMPAT (KBMI 4)
Authors: Kristwanda Princess Natalie Budi , Satria Dias
Published: October 2024

Over the years, the world of technology and innovation has evolved. One of them is the financial sector, namely financial technology (fintech). This study aims to determine how the presence of peer-to-peer lending in Indonesia can have an impact on banking performance in Indonesia, proxied by return on assets (ROA) because it is indicated that fintech cuts the market segmentation of banks. The variables used are the number of companies, the number of lenders, the number of borrowers, and the number of loans whose data is taken from the Financial Services Authority. This type of research is quantitative research using the Error Correction Model (ECM) method approach. The result of this research is that the presence of peer-to-peer lending will synergize with KBMI 4 Bank and produce a mutually beneficial relationship.
PENGARUH E-BANKING TERHADAP KINERJA KEUANGAN (STUDI KASUS PADA PERBANKAN DENGAN MARKET CAP TERATAS DI INDONESIA)
Authors: Purnamasari Natasya Yunior , Fadli Faishal
Published: October 2024

The use of technology in the banking sector is currently growing rapidly with the presence of E-banking. E-banking may affect financial performance and can increase banking profits. The purpose of this study is to determine the effect of E-banking on the financial performance of banks with the top market cap. ROA is used as the dependent variable to represent financial performance. The independent variables used are ATM, M-banking, DPK and BOPO by adding bank size as a control variable. The samples used are BBCA, BBRI, BMRI, BBNI and MEGA. The type of data used is secondary data with panel data regression analysis of the annual financial report data of each bank from 2015-2022. The results of this study are ATM, M-banking and BOPO have a significant effect on ROA while DPK has no significant effect on ROA. Simultaneously, ATM, M-banking, DPK, BOPO and Bank Size variables have a significant effect on ROA. Therefore, the implication of this research is that banks focus on improving and developing E-banking in order to increase bank profits which will improve the bank's financial performance.
Pengaruh Kinerja Keuangan dengan Pendekatan Dupont System terhadap Return Saham Perusahaan Asuransi di Indonesia dengan ROE Dupont sebagai Variabel Moderasi
Authors: Abadiyah Fajriyatul
Published: October 2024

ABSTRACTThis research aims to analyze the influence of financial performance using the Dupont system approach on stock returns in insurance companies, and to find out whether there is a role for Dupont ROE as a moderating variable. This research used a sample of 14 insurance companies listed on the IDX using a purposive sampling approach. Data comes from quarterly financial reports and stock prices from 2019 to 2021. The data analysis methods used are panel data regression and moderated regression analysis (MRA) interaction tests using the WarpPls 8.0 program. The research results show that NPM has no significant effect on stock returns, while TATO and EMR have a significant positive effect on stock returns. Furthermore, in the moderation analysis, the statistical results concluded that Dupont's ROE was not able to moderate the relationship between NPM and stock returns or EMR and stock returns, but Dupont's ROE was able to moderate the relationship between TATO and insurance stock returns.Keywords: Financial Performance, Dupont System, Stock Returns, Insurance CompaniesABSTRAKPenelitian ini bertujuan untuk menganalisis pengaruh kinerja keuangan dengan pendekatan Dupont system terhadap return saham pada perusahaan asuransi, serta mengetahui apakah terdapat peran ROE Dupont sebagai variabel moderasi. Penelitian ini menggunakan 14 sampel perusahaan asuransi yang terdaftar di BEI dengan pendekatan purposive sampling. Data bersumber dari laporan keuangan kuartal dan harga saham dari tahun 2019 sampai 2021. Metode analisis data yang digunakan yaitu regresi data panel dan uji interaksi moderated regression analysis (MRA) melalui program WarpPls 8.0. Hasil penelitian menunjukkan bahwa NPM tidak berpengaruh signifikan terhadap return saham, sedangkan TATO dan EMR berpengaruh positif signifikan terhadap return saham. Lebih lanjut pada analisis moderasi, hasil statistik menyimpulkan ROE Dupont tidak mampu memoderasi dalam hubungan NPM dan return saham maupun pada EMR dan return saham, namun ROE Dupont mampu memoderasi dalam hubungan antara TATO dan return saham asuransi.Kata kunci: Kinerja Keuangan, Sistem Dupont, Pengembalian Saham, Perusahaan Asuransi
Faktor yang Mempengaruhi Niat Penggunaan Layanan E-Wallet ShopeePay
Authors: Mujilan Mujilan , Mongilala Maria Stella
Published: October 2024

ABSTRACTThe purpose of this study is to examine the factors that affect the intention to use the ShopeePay e-wallet. The research is conducted by distributing questionnaires with 150 data processed. Respondents are obtained from the ShopeePay users in Madiun City. Data is processed by PLS Structural Equation Modeling (PLS SEM). The results show that the perceptions of ease of use, security, and trust have a positive impact on the intention to continue using the ShopeePay e-Wallet service. The strongest influence is on the perceived of security. Then the lower level is the perceived trust, and then the perceived ease of use. Thus, the users will continue using an e-wallet service by considering security first, then trust in the service. The perception of ease of use has a positive impact, however it is estimated that when users become more frequent and skilled at operating the service system, it will feel more familiar and easier to operate the system. Keywords: e-money, e-wallet, m-wallet, m-payment, intention to useABSTRAKTujuan penelitian ini untuk menguji faktor-faktor yang mempengaruhi niat penggunaan e-Walllet ShopeePay. Penelitian dilakukan dengan penyebaran kuesioner dengan data diolah sebanyak 150 data. Responden berasal dari masyarakat Kota Madiun yang menggunakan ShopeePay. Data diolah dengan Structural Equation Modeling (SEM) menggunakan Smart PLS. Hasil menunjukkan bahwa persepsi kemudahan, keamanan, dan kepercayaan berpengaruh positif terhadap niat untuk terus menggunakan layanan e-Wallet ShopeePay.  Pengaruh terkuat ada pada persepsi keamanan. Kemudian level lebih rendah adalah persepsi kepercayaan, dan kemudian persepsi kemudahan. Dengan demikian para pengguna untuk melanjutkan menggunakan suatu layanan berpikir dahulu tentang keamanan, kemudian kepercayaan pada layanan. Persepsi kemudahan memang berdampak positif, namun diperkirakan ketika pengguna makin sering dan mahir mengoperasikan sistem layanan maka akan lebih terasa familiar dan makin mudah mengoperasikan sistem.Kata kunci: e-money, e-wallet, m-wallet, m-payment, niat penggunaan