bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S1 from Neem Leaf Glycoprotein Disrupts Exhausted CD8+ T-Cell–Mediated Cancer Stem Cell Aggression
Authors: Chakravarti Mohona , Bera Saurav , Dhar Sukanya , Sarkar Anirban , Choudhury Pritha Roy , Ganguly Nilanjan , Das Juhina , Sultana Jasmine , Guha Aishwarya , Biswas Souradeep , Das Tapasi , Hajra Subhadip , Banerjee Saptak , Baral Rathindranath , Bose Anamika
Published: August 2024

The file contains Supplementary Figure S1
Table S3 from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

WES results
Table S1 from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

Tumors list
Figure S6 from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

Supplementary Figure S6. Metabolomics of Wilms tumors were used to determine differential abundance of metabolites, expressed as log2-fold-change in tumors with microRNA processing mutations versus without such mutations, demonstrating that the antioxidant BH4 is depleted in tumors with microRNA processing mutations.
Figure S5 from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

Supplementary Figure S5. Structure of DROSHA RNase IIIb metal-binding pocket.
Supplementary Table 1 from Pediatric Chordoma: A Tale of Two Genomes
Authors: O’Halloran Katrina , Hakimjavadi Hesamedin , Bootwalla Moiz , Ostrow Dejerianne , Kerawala Rhea , Cotter Jennifer A. , Yellapantula Venkata , Kaneva Kristiyana , Wadhwani Nitin R. , Treece Amy , Foreman Nicholas K. , Alexandrescu Sanda , Velazquez Vega Jose , Biegel Jaclyn A. , Gai Xiaowu
Published: August 2024

Pediatric chordoma cohort counts of rare nonsynonymous variants determined from somatic exome sequencing in COSMIC Cancer Census Genes, broken down by variant class (VEP).
Supplementary Figure 7 from NSCLC Extracellular Vesicles Containing miR-374a-5p Promote Leptomeningeal Metastasis by Influencing Blood‒Brain Barrier Permeability
Authors: Jin Jie , Cui Yumeng , Niu Huicong , Lin Yanli , Wu Xiaojie , Qi Xuejiao , Bai Kaixuan , Zhang Yu , Wang Youliang , Bu Hui
Published: August 2024

EVs miR-374a-5p down-regulates ADD3 and reduces cell-cell junctions.
Supplementary Figure 6 from NSCLC Extracellular Vesicles Containing miR-374a-5p Promote Leptomeningeal Metastasis by Influencing Blood‒Brain Barrier Permeability
Authors: Jin Jie , Cui Yumeng , Niu Huicong , Lin Yanli , Wu Xiaojie , Qi Xuejiao , Bai Kaixuan , Zhang Yu , Wang Youliang , Bu Hui
Published: August 2024

ADD3 restored cell-cell junctions.
Supplementary figure 5 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

RNAseq analysis
Supplementary figure 11 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

Ispinesib dose response
Supplementary figure 10 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

Androgen receptor expression in lethal prostate cancer PDX models
Supplementary Figures 1-6 from Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells
Authors: Picco Gabriele , Rao Yanhua , Al Saedi Angham , Lee Yang , Vieira Sara F. , Bhosle Shriram , May Kieron , Herranz-Ors Carmen , Walker Samantha J. , Shenje Raynold , Dincer Cansu , Gibson Freddy , Banerjee Ruby , Hewitson Zoe , Werner Thilo , Cottom Joshua E. , Peng Yang , Deng Nanhua , Zhang Youyou , Nartey Eldridge N. , Nickels Leng , Landis Philip , Conticelli Daniela , McCarten Katrina , Bush Jacob , Sharma Mamta , Lightfoot Howard , House David , Milford Emma , Grant Emma K. , Glogowski Michal P. , Wagner Craig D. , Bantscheff Marcus , Rutkowska-Klute Anna , Zappacosta Francesca , Pettinger Jonathan , Barthorpe Syd , Eberl H. Christian , Jones Brian T. , Schneck Jessica L. , Murphy Dennis J. , Voest Emile E. , Taygerly Joshua P. , DeMartino Michael P. , Coelho Matthew A. , Houseley Jonathan , Sharma Geeta , Schwartz Benjamin , Garnett Mathew J.
Published: August 2024

Supplementary Figure 1. Generating base editor-expressing MSI cell lines for screening. Supplementary Figure 2. Quality control for base-editor screens in MSI cell lines. Supplementary Figure 3. Discovery and characterization of novel inhibitors of WRN helicase. Supplementary Figure 4. Correlation of WRN inhibitor sensitivity with genetic and molecular markers in MSI models. Supplementary Figure 5. Comparative analysis of DNA damage in MSI and MSS cells treated with WRN inhibitors and genetic inactivation. Supplementary Figure 6: Effects of GSK_WRN4 on MSI and MSS colorectal cancer xenografts.
Table S2 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer
Authors: Matusiak Magdalena , Hickey John W. , van IJzendoorn David G.P. , Lu Guolan , Kidziński Lukasz , Zhu Shirley , Colburg Deana R.C. , Luca Bogdan , Phillips Darci J. , Brubaker Sky W. , Charville Gregory W. , Shen Jeanne , Loh Kyle M. , Okwan-Duodu Derick K. , Nolan Garry P. , Newman Aaron M. , West Robert B. , van de Rijn Matt
Published: August 2024

Supplementary Table 2. List of CODEX antibodies
Supplementary Table 24 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Single trajectory generalized Born and surface area solvation (MM/GBSA) calculated free energy of ATP binding into the orthosteric pocket.
Supplementary Table 2 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Frequency of MET tyrosine kinase domain (TKD) mutations in cohort #1 according to amino acid residue, out of a total of 711 MET TKD mutations.
Supplementary Table S3 from BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers
Authors: Lei Guang , Mao Chao , Horbath Amber D. , Yan Yuelong , Cai Shirong , Yao Jun , Jiang Yan , Sun Mingchuang , Liu Xiaoguang , Cheng Jun , Xu Zhihao , Lee Hyemin , Li Qidong , Lu Zhengze , Zhuang Li , Chen Mei-Kuang , Alapati Anagha , Yap Timothy A. , Hung Mien-Chie , You Mingjian James , Piwnica-Worms Helen , Gan Boyi
Published: August 2024

Supplementary Table S3 shows sgRNA oligos sequences and primer sequences
Supplementary Table 13 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Concurrent driver mutations according to oncogenic / likely oncogenic MET TKD mutations detected in cohort #2.
Supplementary Table 10 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Characteristics of 44 NSCLC cases harboring oncogenic / likely oncogenic MET TKD mutations in cohort #1.
Table S4 from ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
Authors: Xu Yaru , Yang Yuqiu , Wang Zhaoning , Sjöström Martin , Jiang Yuyin , Tang Yitao , Cheng Siyuan , Deng Su , Wang Choushi , Gonzalez Julisa , Johnson Nickolas A. , Li Xiang , Li Xiaoling , Metang Lauren A. , Mukherji Atreyi , Xu Quanhui , Tirado Carla R. , Wainwright Garrett , Yu Xinzhe , Barnes Spencer , Hofstad Mia , Chen Yu , Zhu Hong , Hanker Ariella B. , Raj Ganesh V. , Zhu Guanghui , He Housheng H. , Wang Zhao , Arteaga Carlos L. , Liang Han , Feng Felix Y. , Wang Yunguan , Wang Tao , Mu Ping
Published: August 2024

Table S4. Candidate Resistance Driver Genes in ZNF397-KO Cells
Supplementary Figures S1-S10 from ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
Authors: Xu Yaru , Yang Yuqiu , Wang Zhaoning , Sjöström Martin , Jiang Yuyin , Tang Yitao , Cheng Siyuan , Deng Su , Wang Choushi , Gonzalez Julisa , Johnson Nickolas A. , Li Xiang , Li Xiaoling , Metang Lauren A. , Mukherji Atreyi , Xu Quanhui , Tirado Carla R. , Wainwright Garrett , Yu Xinzhe , Barnes Spencer , Hofstad Mia , Chen Yu , Zhu Hong , Hanker Ariella B. , Raj Ganesh V. , Zhu Guanghui , He Housheng H. , Wang Zhao , Arteaga Carlos L. , Liang Han , Feng Felix Y. , Wang Yunguan , Wang Tao , Mu Ping
Published: August 2024

Figure S1. ZNF397-deficiency has bifurcated effects on PCa with or without AR inhibition. Figure S2. The impact of ZNF397-deficiency on AR protein and AR cistrome. Figure S3. ZNF397 is required for the activation of canonical AR transcriptional program. Figure S4. ZNF397-KO impairs DHT-induced AR signaling activation. Figure S5. ZNF397-KO promotes multilineage and lineage plastic gene expression. Figure S6. ZNF397-KO promotes stem-like and EMT-like transcriptional programs. Figure S7. ZNF397-KO led to induction of TET2 downstream genes. Figure S8. ZNF397-KO promotes transcriptional activation of TET2 downstream genes. Figure S9. ZNF397-deficiency has bifurcated effects on AR-dependent vs AR-independent PCas. Figure S10. Targeting TET2-driven epigenetic rewiring to overcome resistance.
Table S3 from Lifileucel, an Autologous Tumor-Infiltrating Lymphocyte Monotherapy, in Patients with Advanced Non–Small Cell Lung Cancer Resistant to Immune Checkpoint Inhibitors
Authors: Schoenfeld Adam J. , Lee Sylvia M. , Doger de Spéville Bernard , Gettinger Scott N. , Häfliger Simon , Sukari Ammar , Papa Sophie , Rodríguez-Moreno Juan F. , Graf Finckenstein Friedrich , Fiaz Rana , Catlett Melissa , Chen Guang , Qi Rongsu , Masteller Emma L. , Gontcharova Viktoria , He Kai
Published: August 2024

Representativeness of Study Participants
Figure S1 from Lifileucel, an Autologous Tumor-Infiltrating Lymphocyte Monotherapy, in Patients with Advanced Non–Small Cell Lung Cancer Resistant to Immune Checkpoint Inhibitors
Authors: Schoenfeld Adam J. , Lee Sylvia M. , Doger de Spéville Bernard , Gettinger Scott N. , Häfliger Simon , Sukari Ammar , Papa Sophie , Rodríguez-Moreno Juan F. , Graf Finckenstein Friedrich , Fiaz Rana , Catlett Melissa , Chen Guang , Qi Rongsu , Masteller Emma L. , Gontcharova Viktoria , He Kai
Published: August 2024

CONSORT diagram for Cohort 3B of the IOV-COM-202 study
Supplementary Table S3 from St. Jude Survivorship Portal: Sharing and Analyzing Large Clinical and Genomic Datasets from Pediatric Cancer Survivors
Authors: Matt Gavriel Y. , Sioson Edgar , Shelton Kyla , Wang Jian , Lu Congyu , Zaldivar Peraza Airen , Gangwani Karishma , Paul Robin , Reilly Colleen , Acić Aleksandar , Liu Qi , Sandor Stephanie R. , McLeod Clay , Patel Jaimin , Wang Fan , Im Cindy , Wang Zhaoming , Sapkota Yadav , Wilson Carmen L. , Bhakta Nickhill , Ness Kirsten K. , Armstrong Gregory T. , Hudson Melissa M. , Robison Leslie L. , Zhang Jinghui , Yasui Yutaka , Zhou Xin
Published: August 2024

Risk effects of MAGI3 variants
Supplementary Table S2 from St. Jude Survivorship Portal: Sharing and Analyzing Large Clinical and Genomic Datasets from Pediatric Cancer Survivors
Authors: Matt Gavriel Y. , Sioson Edgar , Shelton Kyla , Wang Jian , Lu Congyu , Zaldivar Peraza Airen , Gangwani Karishma , Paul Robin , Reilly Colleen , Acić Aleksandar , Liu Qi , Sandor Stephanie R. , McLeod Clay , Patel Jaimin , Wang Fan , Im Cindy , Wang Zhaoming , Sapkota Yadav , Wilson Carmen L. , Bhakta Nickhill , Ness Kirsten K. , Armstrong Gregory T. , Hudson Melissa M. , Robison Leslie L. , Zhang Jinghui , Yasui Yutaka , Zhou Xin
Published: August 2024

Major data types on the portal
Supplementary Table S2 from Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2
Authors: Chen Lishu , Qi Qinghui , Jiang Xiaoqing , Wu Jin , Li Yuanyuan , Liu Zhaodan , Cai Yan , Ran Haowen , Zhang Songyang , Zhang Cheng , Wu Huiran , Cao Shuailiang , Mi Lanjuan , Xiao Dake , Huang Haohao , Jiang Shuai , Wu Jiaqi , Li Bohan , Xie Jiong , Qi Ji , Li Fangye , Liang Panpan , Han Qiuying , Wu Min , Zhou Wenchao , Wang Chenhui , Zhang Weina , Jiang Xin , Zhang Kun , Li Huiyan , Zhang Xuemin , Li Ailing , Zhou Tao , Man Jianghong
Published: August 2024

Supplementary Table S2 shows CKB IHC staining score in human glioma microarray.
Supplementary Figure S6 from St. Jude Survivorship Portal: Sharing and Analyzing Large Clinical and Genomic Datasets from Pediatric Cancer Survivors
Authors: Matt Gavriel Y. , Sioson Edgar , Shelton Kyla , Wang Jian , Lu Congyu , Zaldivar Peraza Airen , Gangwani Karishma , Paul Robin , Reilly Colleen , Acić Aleksandar , Liu Qi , Sandor Stephanie R. , McLeod Clay , Patel Jaimin , Wang Fan , Im Cindy , Wang Zhaoming , Sapkota Yadav , Wilson Carmen L. , Bhakta Nickhill , Ness Kirsten K. , Armstrong Gregory T. , Hudson Melissa M. , Robison Leslie L. , Zhang Jinghui , Yasui Yutaka , Zhou Xin
Published: August 2024

Workflow for building custom groups
Supplementary Figure S2 from St. Jude Survivorship Portal: Sharing and Analyzing Large Clinical and Genomic Datasets from Pediatric Cancer Survivors
Authors: Matt Gavriel Y. , Sioson Edgar , Shelton Kyla , Wang Jian , Lu Congyu , Zaldivar Peraza Airen , Gangwani Karishma , Paul Robin , Reilly Colleen , Acić Aleksandar , Liu Qi , Sandor Stephanie R. , McLeod Clay , Patel Jaimin , Wang Fan , Im Cindy , Wang Zhaoming , Sapkota Yadav , Wilson Carmen L. , Bhakta Nickhill , Ness Kirsten K. , Armstrong Gregory T. , Hudson Melissa M. , Robison Leslie L. , Zhang Jinghui , Yasui Yutaka , Zhou Xin
Published: August 2024

Variable and chart types on the portal
A Lei de Defesa da Probidade Administrativa possui um regime jurídico coerente com o Direito Administrativo sancionador?
Authors: Magami Junior Roberto Tadao
Published: August 2024

Law No. 14,230/2021 promoted a significant reconfiguration of the Administrative Improbity Law, as, among other aspects, it consolidated the application of the legal regime of Sanctioning Administrative Law (art. 1, §4), which has already been notoriously applied by the Superior Court of Justice, in contrast to the Federal Supreme Court's understanding that the nature of the assessments was civil. The STF, when the judgment of General Repercussion nº 1199 demonstrated the possible revision of its old understanding regarding the civil nature of the legal regime, but what was the extent and depth of this approach when deciding on the non-retroactivity of the provisions contained in the new legislation exclusively to convictions for negligent acts of improbity, as well as the recognition of the presence of the subjective element – ​​intent – ​​for the configuration of any and all acts of administrative improbity and, finally, the immediate application of the new general and intercurrent limitation periods? What is the true origin of Sanctioning Administrative Law? What is the legal nature of assessments arising from acts that constitute administrative improbity?
The French reading of Kelsen (or how to misinterpret an author and make him say what he does not say)
Authors: Sydoryk Sacha
Published: August 2024

In this paper, I aim to show that in France, Kelsen’s vision of Stufenbau is widely misunderstood and that his name is associated with a specific concept of the “hierarchy of norms” that has nothing to do with his writings. Indeed, the French legal doctrine rejects Kelsen as a whole, but keeps on using a somehow modified version of Kelsen’s concept, called rather “pyramid of norms” rather than “hierarchy of norms”. This very French version of the concept is both used as a way to legitimate the legal order and to criticize legal positivism as a whole, missing far and wide Kelsen’s original point. The main consequence is that in France, Kelsen’s work is mostly restrained to this aspect of his writings, leaving him mostly unread and misunderstood when his name and concepts are used in the first classes of legal studies.
Physical activity and low protein diet intake during pregnancy in female rats: effects on pregnancy course and fetal development
Authors: Silva Rozinaldo Galdino da , Mello Maria Alice Rostom de
Published: August 2024

Para investigar o efeito da exercício físico e da ingestão de dieta hipoprotéica sobre o curso da gestação e o desenvolvimento fetal, ratas W istar com 50 dias e média de massa corporal de 161,lg (± 8,7), foram divididas nos grupos: Normoprotéico Sedentário (NS), Normoprotéico Treinado (NT), Hipoprotéico Sedentário (HS) e Hipoprotéico Treinado (HT). Os grupos “normoprotéicos” receberam dieta com 17% de proteína, e os “hipoprotéicos” com 6% de proteína, as dietas eram isocalóricas. Os grupos treinados realizaram natação 60 minutos por dia, com 5% da massa corporal fixada ao tronco, cinco dias na semana, do lo. ao 17o. dia gestacional. No 19o. dia as ratas foram sacrificadas em repouso, sendo avaliado: a) nas gestantes: glicose, albumina e proteínas totais circulantes; glicogênio no fígado, útero e músculo gastrocnêmio; b) nos fetos: glicose, albumina e proteínas totais circulantes; glicogênio no fígado; teores de DNA e proteína tecidual no cérebro, coração e fígado. NT e HS apresentaram menor ganho de massa corporal que NS e HT. Em relação aos fetos os dos grupos HT e NT tiveram redução na massa corporal em relação aos NS; e os NT e HS menor teor cardíaco de DNA que o NS. Concluindo, treinamento aliado à ingestão de dieta hipoprotéica, porém isocalórica, minimizou os efeitos deletérios dos tratamentos isolados, não havendo alteração no curso da gestação e no desenvolvimento fetal
Critical or sensitive periods: revisiting a polemic them e in the light of the empiric investigation
Authors: Lopes Vítor Pires , Maia José Antônio Ribeiro
Published: August 2024

O objetivo deste trabalho é analisar o conceito de período crítico à luz da investigação empírica disponível. Em primeiro lugar apresenta-se o conceito de período crítico e faz-se uma resenha histórica acerca da sua “evolução” Em seguida analisa-se o problema da determinação dos períodos críticos sendo apresentados os resultados das poucas investigações realizadas nesta temática no âmbito das aptidões motoras. Os resultados destas investigações evidenciam alguma contradição nas suas conclusões. Posteriormente é analisada a questão da treinabilidade e da sua dependência genética. Conclui-se: a) que existe uma grande falta de estudos empíricos que abordem a questão dos períodos críticos ou sensíveis, não estando confirmada ou reprovada a idéia da sua existência no treino de aptidões motoras e aprendizagem de habilidades; b) o grau de treinabilidade é influenciado pelo genótipo, verificando-se uma forte interação genótipo x envolvimento, ocasionando uma grande variação inter-individual no grau de sensibilidade ao treino e instrução
Ergogenic effects of caffeine on performance
Authors: Altimari Leandro Ricardo , Cyrino Edilson Serpeloni , Zucas Sérgio Miguel , Burini Roberto Carlos
Published: August 2024

A cafeína é uma substância que não apresenta valor nutricional, sendo classificada como um alcalóide farmacologicamente ativo, estimulante do sistema nervoso central (SNC). No entanto, esta substância tem sido considerada um ergogênico nutricional por estar presente em várias bebidas consumidas diariamente, tais como o café, o chocolate, o mate, e algumas bebidas suaves à base de guaraná. O seu uso tem-se tornado bastante comum no meio esportivo, principalmente nos últimos anos, particularmente por atletas que disputam provas de resistência. A possibilidade de melhora do desempenho físico fez com que este alcalóide entrasse na lista de substâncias proibidas pelo Comitê Olímpico Internacional (COI), o qual estabeleceu o limite de 12 jig/ml de cafeína na urina como parâmetro para detecção de “doping” Alguns estudos têm demonstrado que esses níveis podem ser alcançados com a ingestão de aproximadamente 9 mg de cafeína por quilograma de peso corporal. Todavia, estudos mais recentes têm evidenciado melhora no desempenho atlético com a ingestão de apenas 3 a 6 mg de cafeína por quilograma de peso corporal. Tais observações parecem colocar em risco o limite tolerável estipulado pelo COI, o que poderia favorecer a melhoria do rendimento por parte dos usuários. Esses fatos demonstram a necessidade de maiores investigações sobre o efeito ergogênico de diferentes dosagens de cafeína e, possivelmente, de revisão dos níveis de ingestão toleráveis
Sport initiation and specialization in Sao Paulo
Authors: Arena Simone Sagres , Bohme Maria Tereza Silveira
Published: August 2024

Este estudo teve como objetivo verificar e analisar as formas de iniciação e especialização esportiva, adotados por clubes e secretarias municipais de esportes da Região da Grande São Paulo, de modalidades individuais (atletismo, ginástica, natação, judô e tênis) e coletivas (basquetebol, futsal, handebol e voleibol). Para isso, foram aplicadas entrevistas semi-estruturadas com uma amostra intencional de 15 entidades esportivas. Os resultados indicaram que as entidades promovem treinamento específico em faixas etárias abaixo das recomendadas pela literatura nas modalidades pesquisadas. O estudo permitiu também sugerir propostas de reformulações no processo de iniciação e formação esportiva de jovens atletas
Bonobo geophagy at Wamba
Authors: Toda Kazuya , Fasbender David
Published: August 2024

Geophagy, the deliberate consumption of earth materials, is widely observed in animals. While anecdotal evidence exists of bonobos (Pan paniscus) consuming soil from Cubitermes termite mounds, the functions of their geophagic behavior remains unexplored. This study aims to examine a preliminary hypothesis that termite mound geophagy of free-ranging bonobos at Wamba are helpful for iron supplementation. Here, we tested the following three predictions: (1) the soil of Cubitermes termite mounds at Wamba would have high iron content, (2) bonobos would engage in termite mound geophagy regularly across all seasons, and (3) termite mound soil would be more often consumed by (a) females than males, (b) pregnant than non-pregnant females, and (c) adolescents than adults. As predicted, soil samples collected from the pointy protrusions on the caps of the mushroom-shaped mounds, the part typically consumed by bonobos, had a much higher iron content than other food items for them. In addition, geophagic behavior was noted on 48 out of 116 days (41.3%) with full-day focal animal sampling, and was observed throughout the entire study duration without any bias in frequency toward a certain period. However, contrary to our prediction, there was no significant variation in the frequency of geophagic behavior by sex nor by pregnancy status, although it occurred more frequently among adolescents than adults. Our findings partially support the Iron Supplementation Hypothesis, suggesting that Cubitermes termite mound soils could offer a readily accessible source of iron for bonobos. However, we cannot draw definitive conclusions on the function of their geophagic behavior from our findings without in vitro studies examining whether the ingested iron is bioavailable and whether the soil does not have properties inhibiting iron absorption. Nonetheless, this study is a first step to explore the health implications of geophagy in bonobos, extending our knowledge of this behavior in primates.
The Effect of Intra-household Mobile Phone Use on Household Food and Nutrition Security in Tanzania
Authors: Ngwilizi David , Selejio Onesmo , Ruhinduka Remidius D.
Published: August 2024

This study explores the effect of intra-household mobile phone use on household food and nutrition security in Tanzania. It utilises the sample size of 1,184 households with information on male and female mobile phone use status from the National Panel Survey-Sex Disaggregated Data (NPS-SDD) collected in 2019/20. To offset the potential endogeneity bias from gender digital use choice, the study employs instrumental variable regression and a bivariate probit model in the analysis. The results indicate that the magnitude of the effect of female mobile phone users on household food and nutrition security is consistently larger and statistically significant than that of male mobile phone users. It also demonstrates that mobile phone users in rural areas have a more significant effect on a household’s welfare than their counterparts in urban areas. These findings highlight the importance of closing the gender digital inclusion gap and urban-rural digital disparities to expedite efforts to improve households’ well-being.
Etosha-Kunene Conservation Conversations
Authors: Sullivan Sian , Dieckmann Ute , Lendelvo Selma
Published: August 2024

This introductory chapter describes how the Etosha- Kunene Histories research project, for which this edited volume forms a key contribution, addresses the challenge of conserving biodiversity-rich landscapes in Namibia’s north-central and north-west regions, while reconciling historical contexts of social exclusion and marginalisation. This edited volume, originating from an international workshop held in July 2022, explores the intricate interplay between local and global events shaping the “Etosha Kunene” conservation landscape. The workshop featured diverse participants from Namibian institutions, international universities, and various conservation organisations. Our discussions emphasised the complex histories and contemporary dynamics of conservation policies, highlighting the tension between biodiversity protection and social equity. The volume is organised into five parts: historical policy analysis, post-independence conservation approaches, ecological management issues, the impact of historical contexts on contemporary landscapes and communities, and lion conservation within Community-Based Natural Resource Management frameworks. This work aims to contribute to sustainable and inclusive conservation practices that honour both the region’s natural and cultural heritage.
8. Eliciting empathy and connectedness toward different species in north-west Namibia
Authors: Zuvee Katjirua Likeleli , Shipepe David Michael , Muntifering Jeff
Published: August 2024

This chapter turns to research with young people in north-west Namibia to ascertain their perceptions and understandings of “wildlife”. The aim is to better understand how young members of communal-area conservancies in north-west Namibia know and perceive the value of selected indigenous fauna species in these areas, alongside domestic livestock––specifically goats (Capra hircus). This study is set within a context in which tourism in Namibia is understood to greatly contribute to Gross Domestic Product (GDP), with Namibia being home to animals whose value is linked with their contemporary scarcity. Such species include black rhino (Diceros bicornis bicornis)––monitored and celebrated through organisations and campaigns such as Save the Rhino Trust and the Rhino Pride Campaign––as well as lion (Panthera leo), and oryx (Oryx gazella), all of which draw tourists to Namibia. Whilst these wild animals need to be protected at a global level, nationally they are also Namibia’s pride, even being pictured as nationally important symbols on Namibian bank notes.
10. Are mountain and plains zebra hybridising in north-west Namibia?
Authors: |Uiseb ǂKîbagu Heinrich Kenneth
Published: August 2024

This chapter focuses on interactions between two animal species critical to the ecosystems of Etosha-Kunene, namely mountain zebra (Equus zebra, specifically the subspecies E. z. hartmannae) and plains zebra (E. quagga, specifically the subspecies E. q. burchellii). Large herbivore species are increasingly restricted to fenced protected areas with artificial waterpoints, a situation that limits their opportunities for dispersal and access to natural water sources. This restricted movement may lead to genetic consequences including disruption of gene flow, inflation of “inbreeding”, and the loss of rare alleles supporting local adaptation and genetic fitness. In Namibia’s large protected area of Etosha National Park, mountain zebra are restricted to the dolomite ridges in the far western section of the park while plains zebra occur throughout the park. Historically, the overlap in range of the two zebra species was limited, as plains zebra confined their movements to the southern and eastern edges of the Etosha Pan during the dry season, and to the open plains west of the Pan during the rainy season. Due to fencing and new waterpoint creation, this extended overlap of these two previously geographically separated species creates a potential conservation problem in the form of hybridisation between the two species. This chapter reviews what is known about the hybridisation of these two species, and considers implications for conservation and for future research.
11. Communities and elephants in the northern highlands, Kunene Region, Namibia
Authors: Wenborn Michael , Collinson Roger , Muzuma Siegfried , Kangombe Dave , Nijman Vincent , Svensson Magdalena S.
Published: August 2024

We consider a unique population of elephant (Loxodonta africana) dwelling in an area known as the northern highlands to the west of Etosha National Park. These highlands are a remote, arid, mountainous landscape where elephants co-exist with rural communities. There is minimal published research on this population of elephants. As part of our scoping for a research project on this population of elephants, we consulted with game guards from 10 conservancies in 2021 and 2022 on their knowledge of elephant populations, and carried out analysis of Event Book data on human-elephant conflict (HEC) incidents reported in Orupupa and Ehi-Rovipuka conservancies. The community conservancy model has had much success in shaping local attitudes in Kunene Region and increasing the perceived value of wildlife. These successes are being eroded, however, by competition between local people and wildlife over resources––particularly in the context of drought years in north-west Namibia between 2013 and 2020. We conclude that there is a strong case for expanding the roles of community game guards to strengthen the protection of the elephants in the northern highlands. One suggestion is for community game guards to be offered additional training as “elephant rangers” who can guide tourists in the area, the assumption being that this would increase revenue to community conservancies and help to enhance local perceptions of the value of wildlife.
16. History and social complexities for San at Tsintsabis resettlement farm, Namibia
Authors: Koot Stasja , ǁKhumûb Moses
Published: August 2024

The theme of the 1950s eviction of Haiǁom Indigenous people from the protected area that became Etosha National Park is continued in this chapter. After this event, many Haiǁom San became farm workers. Having lost their lands under colonialism and apartheid to nature conservation and large-scale livestock ranching, most remained living in the margins of society at the service of white farmers, conservationists or the South African Defence Force (SADF). After Independence in 1990, group resettlement farms became crucial to address historically built-up inequalities by providing marginalised groups with opportunities to start self-sufficient small-scale agriculture. This chapter critically addresses the history of the Tsintsabis resettlement farm, just over a 100 kms east of ENP, where at first predominantly Haiǁom (and to a lesser degree !Xun) were “resettled” on their own ancestral land, some as former evictees from ENP. The history of Tsintsabis is analysed in relation to two pressing, and related, social complexities at this resettlement farm, namely: 1) ethnic tension and in-migration; and 2) leadership. The chapter argues that the case of Tsintsabis shows the importance of acknowledging historically built-up injustices when addressing current social complexities. The importance of doing long-term ethno-historical research about resettlement is thereby emphasised in order to be able to better understand the contextual processes within which resettlement is embedded.
Transplantation in adult patients with Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis: yes or no?
Authors: Yao Shuyan , He Lingbo , Suolitiken Dina , Zou Heshan , Zhu Yingxin , Wang Yini
Published: August 2024

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by aberrant immunological activity with a dismal prognosis. Epstein-Barr virus (EBV)–associated HLH (EBV-HLH) is the most common type among adults. Patients with EBV infection to B cells could benefit from rituximab, whereas lethal outcomes may occur in patients with EBV infection to T cells, nature killer cells, or multilineages. The necessity of allogeneic hematopoietic stem cell transplantation (HSCT) in adult patients with EBV-HLH remains controversial. A total of 356 adult patients with EBV-HLH entered this study. Eighty-eight received HSCT under medical recommendation. Four received salvage HSCT. The 5-year overall survival (OS) rate for patients who underwent HSCT was 48.7% (vs 16.2% in patients who did not undergo transplantation; P < .001). There was no difference in OS between patients who received transplantation at first complete response (CR1) and those at first partial response (PR1) nor between patients at CR1 and CR2. Patients who received transplantation at PR2 had inferior survival. The rate of reaching CR2 was significantly higher in patients with CR1 than PR1 (P = .014). Higher soluble CD25 levels, higher EBV-DNA loads in plasma after HSCT, poorer remission status, more advanced acute graft-versus-host disease (GVHD), and the absence of localized chronic GVHD were associated with inferior prognosis (P < .05). HSCT improved the survival of adult EBV-HLH significantly. For patients who achieved PR after initial treatment, HSCT was recommended. A wait-and-see strategy could be adopted for patients who achieved CR after initial treatment but with the risk of failing to achieve CR2.
The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia
Authors: Jankovic Maja , Poon William W. L. , Gonzales-Losada Cristobal , Vazquez Gabriela Galicia , Sharif-Askari Bahram , Ding Yi , Craplet-Desombre Constance , Ilie Alexandru , Shi Jiantao , Wang Yongjie , Jayavelu Ashok Kumar , Orthwein Alexandre , Mercier François Émile
Published: August 2024

For several decades, induction therapy with nucleoside analogs, in particular cytarabine (Ara-C) and, to a lesser extent, fludarabine, has been the standard of care for patients diagnosed with acute myeloid leukemia (AML). However, the antitumor efficacy of nucleoside analogs is often limited by intrinsic and acquired drug resistance, thereby leading to poor therapeutic response and suboptimal clinical outcomes. In this study, we used genome-wide CRISPR-based pharmacogenomic screening to map the genetic factors that modulate the response to nucleoside analogs in AML and identified the E3 ubiquitin ligase, Herc1, as a key modulator of Ara-C response in mouse AML models driven by the KMT2A/MLLT3 fusion or by the constitutive coexpression of Hoxa9 and Meis1, both in vitro and in vivo. Loss of HERC1 enhanced nucleoside analog–induced cell death in both murine and human AML cell lines by compromising cell cycle progression. In-depth proteomic analysis and subsequent validation identified deoxycytidine kinase as a novel target of Herc1 in both mouse AML models. We observed that HERC1 is overexpressed in AML when compared with other cancer types and that higher HERC1 expression was associated with shorter overall survival in patients with AML in the The Cancer Gene Atlas program (TCGA) and BEAT-AML cohorts. Collectively, this study highlights the importance of HERC1 in the response of AML cells to nucleoside analogs, thereby establishing this E3 ubiquitin ligase as a novel predictive biomarker and potential therapeutic target for the treatment of AML.
The influence of exercise intensity on comorbid anxious behavior in psychiatric conditions
Authors: Hwang Dong-Joo , Kim Tae-Kyung
Published: August 2024

Many experts have extensively studied the potential of exercise as a treatment option for psychiatric conditions, including depression and autism spectrum disorder (ASD). Despite their core symptoms, these conditions exhibits comparable component traits, an anxiety. In this study, we explored the effect of exercise on behavioral abnormalities in psychiatric conditions, focusing on its intensity and emotional resilience. Shank3B knockout (KOSED) mice displaying self-injurious repetitive behavior and C57BL/6J mice, susceptible to stress as ASD and depression model, respectively, were subjected to moderate-intensity exercise (ME) for 2 weeks. ME mitigated the core symptoms (excessive grooming traits and behavioral despair) but did not exert a significant anxiolytic effect. Notably, exercise intensity has emerged as a critical determinant of its efficacy, as evidenced by a lower ventilation threshold and anxiolytic effect mediated by low-intensity exercise. The findings substantiate the notion that exercise is promising as a disease-modifying treatment, but intensity matters for emotional resilience.

Graphical Abstract
Effect of dapagliflozin on readmission and loop diuretics use in patients with acute heart failure: a retrospective propensity score-matched cohort study
Authors: Wu Dong , Ma Zhen , Wang Xiaoying , Wang Xiaowu , Wang Xiaojuan
Published: August 2024

Background

The efficacy of dapagliflozin in patients with acute heart failure remains unclear.

Objective

To investigate the impact of dapagliflozin (DAPA) on loop diuretics use and 90-day readmission in patients with acute heart failure.

Methods

In a retrospective cohort study, patients diagnosed with acute heart failure or chronic heart failure with acute exacerbation admitted to Fuyang People’s Hospital from January 2021 to April 2023, this study used DAPA (at a dose of 10 mg once daily) in combination with standard treatment. The patients were divided into DAPA group and DAPA-Free group based on whether they used DAPA in acute heart failure. To minimize the influence of confounding factors and ensure comparability between groups, we used propensity score matching (PSM).

Results

A total of 399 patients were included, with 206 patients (51.63%) in the DAPA group and 193 patients (48.37%) in the DAPA-Free group. PSM produced 160 pairs. After PSM, there were no statistically significant differences between the DAPA and DAPA-Free groups in terms of readmission of all causes (16.88% vs. 18.12%, OR 0.9141, 95% CI 0.5385–1.552, log rank P = 0.739) or readmission for heart failure (11.88% vs. 15.0%, OR 0.9077, 95% CI 0.4441–1.469, log rank P = 0.484) after 90-day follow-up. Patients in the DAPA group had a lower mean daily dose of intravenous loop diuretics compared to the DAPA-Free group (20 mg/d vs. 30.00 mg/d, P<0.001), lower total loop diuretic dose during hospitalization (106.06 ± 31.23 mg vs. 144.50 ± 45.39 mg, P = 0.038) and a decreased number of diuretic types used (11.88% vs. 23.12%, P = 0.008).

Conclusions

DAPA reduced the dose of intravenous loop diuretics. However, it did not improve all-cause readmission for 90 days or readmission for heart failure after discharge.
“It’s just part of who I am…” Living with chronic headache: voices from the CHESS trial, a qualitative study
Authors: Nichols Vivien P. , Ellard David R. , Griffiths Frances E. , Underwood Martin , Haywood Kirstie L. , Taylor Stephanie J. C. ,   On behalf of the CHESS team (Consortium), Nichols Vivien , Griffiths Frances , Achana Felix , Carnes Dawn , Eldridge Sandra , Hee Siew Wan , Higgins Helen , Mistry Dipesh , Mistry Hema , Newton Sian , Norman Chloe , Padfield Emma , Patel Shilpa , Petrou Stavros , Pincus Tamar , Potter Rachel , Sandhu Harbinder , Stewart Kimberley , Matharu Manjit
Published: August 2024

Background

Between 2015 and 2019 the Chronic Headache Education and Self-management Study (CHESS) developed and tested a supportive self-management approach that aimed to improve outcomes for people with chronic migraine or chronic tension type headache with/without episodic migraine. However, a paucity of qualitative research which explored the lived experiences of people with chronic headache was evidenced. In response, we undertook to explore the experiences of living with chronic headaches of people who participated in the CHESS study.

Methods

We adopted qualitative methodologies, inviting participants in the CHESS study to participate in semi-structured interviews. In phase 1 (feasibility study), a thematic analysis was conducted. In phase 2 (main CHESS trial), interviews were informed by topic guides developed from our learning from the phase 1 interviews. Pen portrait methodology and thematic analysis was employed allowing us to explore the data longitudinally.

Results

Phase 1, 15 interviews (10 female) age range 29 to 69 years (median 47 years) revealed the complexities of living with chronic headache. Six overarching themes were identified including the emotional impact and the nature of their headaches. Phase 2, included 66 interviews (26 participants; median age group 50s (range 20s-60s); 20 females. 14 were interviewed at three points in time (baseline, 4 and 12 months) Through an iterative process four overlapping categories of headache impact emerged from the data and were agreed: i) ‘I will not let headaches rule my life’; ii) ‘Headaches rule my life’; iii) ‘Headaches out of control—something needs to change’; and iv) ‘Headaches controlled—not ruling my life’. One of these categories was assigned to each pen portrait at each timepoint.

The remaining 12 participants were interviewed at two time points during a year; pen portraits were again produced. Analysis revealed that the headache impact categories developed above held true in this sample also providing some validation of the categories.

Conclusions

These data give an insight into the complexities of living with chronic headache. Chronic headache is unpredictable, permeating all aspects of an individual’s life; even when an individual feels that their headache is controlled and not interfering, this situation can rapidly change. It shows us that more work needs to be done both medically and societally to help people living with this often-hidden condition.

Trial registration

ISRCTN79708100