bluuebunny/crossref_metadata_2025 huggingface dataset:
Cheng Te-k'un, Studies in Chinese Archaeology (Institute of Chinese Studies Centre for Chínese Archaeology and Art Studies Series No. 3), Hong Kong, The Chinese University Press, 1982, xii + 148 pp.
Authors: Maeth Ch. Russell
Published: March 2024

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Presentación
Authors: - -
Published: March 2024

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Clippers are superior to scissors in the collection of hair for chemical analysis in companion dogs: a Dog Aging Project preliminary study
Authors: Ditzler Bobbie , Evans Jeremy B. , Illing Kate , Kaeberlein Matt , Promislow Daniel E. L. , Brindle Eleanor , Hoffman Jessica M. , Creevy Kate E.
Published: March 2024

OBJECTIVE

To identify the safest, most efficient method for hair sample collection from companion dogs among clippers, scissors, and razors and to validate obtained samples with cortisol concentration analysis.

ANIMALS

25 healthy, privately owned dogs.

METHODS

2 hair samples were collected from each dog’s ischiatic region with different implements (scissors, razors, or clippers). The collecting clinician completed a Hair Collection Questionnaire (HCQ) for each sample that compared subjective sample quality, time of collection, restraint needed, and patient experience. Each sample was evaluated by cortisol enzyme immunoassay.

RESULTS

Clippers had higher overall HCQ scores than scissors, and scissors had higher HCQ scores than razors. Collection was faster for clippers than scissors, and scissors were faster than razors. There were no differences in sample quality between scissors and clippers, and sample quality was lower with razors. There was no difference in restraint needed or patient experience. Collection of long hair had higher HCQ scores than collection of medium and short hair. Collection of hair from dogs with an undercoat had higher HCQ scores than collection of hair from dogs without an undercoat. Dog size had no effect on HCQ score. Hair cortisol concentration did not vary between scissors or clippers (P = .111). Hair color and age did not affect hair cortisol concentration (P = .966 and P = .676, respectively).

CLINICAL RELEVANCE

Clippers are recommended for hair sample collection from companion dogs. Scissors are an adequate alternative.
Harmonizing Technology and Tradition: The Impact of Blended Teaching in Chinese Primary and Secondary Music Education
Authors: Zhi Guan Xing , Thoe Ng Khar
Published: March 2024

Purpose：The purpose is to examine the effectiveness of blended teaching methods in music education, aiming to enhance student engagement, comprehension, and academic performance while addressing the challenges and opportunities of incorporating technology into traditional music pedagogy.
 
Theoretical References：This paper employs a theoretical framework that merges social constructivism and sociocultural theory with blended music education. It focuses on integrating technology to enhance personalized learning, critical thinking community building in music teaching, informed by Guan et al. (2023).
 
Methodology：This study utilized a quantitative research design with a novel 5-point Likert scale questionnaire involving 70 music educators from primary and secondary schools in central China. Data were collected through an online survey platform and analyzed in four dimensions using SPSS24, with methods including descriptive statistics, reliability and validity tests, and correlation analysis.
 
Results and Conclusions：The findings suggest that blended teaching significantly enhances the quality of music education, increases student engagement, and promotes diverse pedagogical approaches. Challenges include maintaining student engagement and navigating technological complexities, but overall, the benefits outweigh these hurdles.
 
Research Implications：This study highlights the significant impact of blended learning approaches on music education in Chinese elementary and middle schools. It calls for a systematic integration of these methods into music curricula to improve student learning experiences. Key recommendations include enhancing teachers' technological skills, ensuring students have equal access to digital resources, and utilizing technology to augment traditional teaching practices.
 
Originality/Value：This research stands out for its detailed exploration of blended teaching methods in Chinese music education, a topic not widely covered in existing studies. It presents evidence of both the advantages and challenges of using technology in music education, offering important insights and practical suggestions for educators, curriculum designers, and policymakers to better incorporate technology into music education strategies.
Knowledge and practice of hypertensive patients toward prevention and early detection of chronic kidney disease and associated factors in Riyadh, Saudi Arabia
Authors: Aloriney Abdulmalik , Alghamdi Rayan , Jailan Abdullah , Alhinti Mohammad , Aljaser Abdulrahman
Published: March 2024

Objective: This study aimed to determine the knowledge, attitude, and practices of hypertensive patients toward chronic kidney disease (CKD).
Methods: A cross-sectional study was conducted from September to November 2021 in Riyadh, Saudi Arabia, using a semi-structured questionnaire that had been previously prepared and tested.
Results: In this study, data from 417 hypertensive patients were collected. Among them, 52.5% were males and 23.5% were aged between 50 and 60 years, while in general, 56.1% were older than 40 years old. In general, it was found that 53.5% of hypertensive patients had an inadequate level of knowledge regarding CKD. The main practices of the participants to reduce the risk of kidney disease included not smoking (77.5%), seeking medical help if they noticed signs of kidney disease (67.1%), following medication regimen (57.8%), and regular exercise such as walking and jogging (41.2%).
Conclusion: It was found that less than half of the hypertensive patients had adequate knowledge considering CKD. There is an urgent need to increase the awareness of the patients toward CKD risk factors. Moreover, it was found that patients had a good attitude and practice considering the risk factors.
Tepung Premix Cookies Berbahan Dasar Mocaf dan Sagu Dengan Perlakuan Penyangraian Suhu Yang Berbeda
Authors: Kurniawati Elly , Agustina Anis
Published: March 2024

Flour premix cookies are used as an alternative to making processed food in an instant way. Flour premix cookies are made by mixing mocaf, sago, powdered sugar, milk powder, and baking powder. This study aims to determine the relationship between mocaf and sago formulations and different roasting temperatures on the value of water content (premix flour), texture (cookies), and organoleptic (cookies) based on the best formulation. Formulation of mocaf and sago as the main factor F1 (75:25), F2 (50:50), and F3 (25:75) and roasting temperature as the second factor P1 (no roasting), P2 (700C), and P3 (800C). This resulted in 9 treatments P1F1, P1F2, P1F3, P2F1, P2F2, P2F3, P3F1, P3F2, and P3F3. The results of this study are that the higher the roasting temperature, the lower the water content, texture, and the decrease in the level of preference.
Karakteristik Fisik, Kimia dan Organoleptik Pancake Menggunakan Tepung Premiks Ampas Kelapa dan Tepung Mocaf
Authors: Silvia Setyorini , Wibisono Yossi
Published: March 2024

Wheat flour is widely used by Indonesians as a basic ingredient for making bread, triggering the ever-increasing import of wheat flour. Therefore, it is necessary to have other alternatives to reduce dependence on the use of wheat flour. One of them is the utilization of coconut pulp waste which is processed into flour and then processed into pancakes with nutritional value and good quality. The purpose of this study was to analyze the effect of the addition of coconut pulp flour on the physical, chemical and organoleptic characteristics of pancakes and determine the best formulation in making pancakes. This study used a Randomized Group Design consisting of 5 treatments (0%, 10%, 20%, 30%, 40%). The results showed that coconut pulp flour gave a significantly different effect on fiber content, texture, specific volume, color a, color b and hedonic test as evidenced by further tests using the Duncan test at the 1% level. While the water content, ash content and color L test showed no significant difference.
Kekuatan Tarik Terhadap Beberapa Sudut Serat Pada Polimer Matrik Komposit Yang Berpenguat Serat Bambu Dengan Perlakuan Di Alkali Untuk Pengembangan Bodi Dan Rangka Kendaraan Elektrik
Authors: Purwanto Hengki , Andary Siti Rodiyah , Hartono Hartono
Published: March 2024

Composite Matrix Polymer is a material formed by two or more combinations, Composite Matrix Polymer is a material consisting of two basic materials, namely matrix and fiber. For fibers it has elastic properties, and the best tensile strength, but also cannot be used against high temperatures, while matric itself has tenacious, soft properties.And it is also binding if it is dry or has reached freezing. This research is to determine the material with natural fibers, namely bamboo fibers that have been processed to such an extent as to realize or entrepreneurial opportunities in the field of body and electric vehicle frames. For this reason, we made this research.To determine the effect of variations in the fibrous angles of composite matrix polymers with angles (0°), (-45°, 45°), and (-45°, 0°, 45°), With bamboo fiber reinforcement for the addition of bamboo fiber variations and with Alkaline treatment at the ratio of NaOH solution levels of 5%, 10%, and 15%, thus to carry out the addition of alkaline treatmentThis study uses experimental methods, and can determine the influence of angular variations, composite matrix polymer fibers with fiber angles (0°), (-45°, 45°), and (-45°, 0°, 45°) reinforced bamboo fibers, with the influence of variations in alkaline dosing of bamboo fibers and the ratio of NaOH solution levels of 5%, 10%, and 15% on the tensile strength of the material.The result of the tests that we have done, is the use of a good 5% alkaline content, a 5% alkaline solution content gets the best fiber speciment form than a 10% and 15% alkaline solution.

And the lowest result is an alkaline content of NaOH 15%. While the best result of angle variation is the angle variation (-45°, 0°, 45°) and the lowest is the angle variation (0°). Which will then be used as a method for learning or practicum modules at the Jember State Polytechnic.
Efektivitas Media Edamame Agar Dengan Penambahan Polymyxin B Sebagai Media Selektif Alternatif Bakteri Bacillus Subtilis
Authors: Nurhayati Dian , Andayani Nanik Andayani , Saing Muhammad Djabir Saing
Published: March 2024

Media selektif Edamame Agar dengan penambahan Polymyxin B   dibuat  bertahap  yaitu pembuatan tepung edamame dan pembuatan  edamame agar + Polymyxin B. Penelitian dilaksanakan pada bulan Juni – September  2023, bertempat di Laboratorium  Analisis Pangan Politeknik Negeri Jember.   Penelitian bertujuan  untuk mengetahui pertumbuhan bakteri Bacillus Subtillis pada  edamame agar dengan penambahan Polymyxin B dan membuat SOP. Metode penelitian dengan membandingkan pertumbuhan bakteri Bacillus Subtilis pada edamame agar dengan media Mannitol Egg yolk polymyxin Agar .Hasil penelitian menunjukkan bahwa jumlah koloni  bakteri Bacillus subtillis pada media dengan penambahan Polymyxin B  0,6 % , 1,1 %, 1,6 %  dan media Mannitol Egg yolk polymyxin Agar  dengan   masa inkubasi 48 jam adalah 3,9  x 105, 2,2 x 105, 1,0 x 105 cfu/ml  dan pada Mannitol Egg yolk polymyxin Agar 3,5 x 105 cfu/ml . Pengujian kimia terhadap koloni yang tumbuh pada  keempat media menunjukkan hasil sama yaitu  Katalase positip, Fermentasi Laktosa negatip , Fermentasi Glukosa positif dan Voges Proskauer  positip. Pengecatan gram  menunjukkan bakteri Bacilus subtilis yang tumbuh pada media Edamame agar dan Mannitol Egg yolk polymyxin Agar   diperoleh hasil bentuknya batang  dan berwarna biru   yaitu termasuk bakteri gram positip.Kesimpulan penelitian adalah media edamame agar  dengan penambahan Polymyxin B mampu menghambat bakteri gram negatip dan  menumbuhkan bakteri  gram positip Bacillus subtillis secara optimal  . Bakteri  Bacillus subtillis yang tumbuh  terbanyak  pada media edamame agar  dengan penambahan Polymyxin B 0,6% dengan TPC 3,9  x 105 cfu/ml lebih tinggi  dibandingkan dengan Mannitol Egg yolk polymyxin Agar   dengan TPC 3,5 x 105 cfu/ml.
Pemanfaatan Computer Vision Sebagai Pemantauan Perkembangan Bibit Tanaman Tomat Berbasis IoT
Authors: Isdi Muhammad Ridho , Harmadi Harmadi
Published: March 2024

Perkembangan bibit tanaman tomat memiliki faktor lingkungan yang harus diperhatikan seperti suhu, kelembapan udara dan intensitas cahaya. Faktor tersebut mempengaruhi keadaan bibit dari hari ke hari. Penelitian ini memanfaatkan computer vision untuk memantau perkembangan bibit tanaman tomat berbasis IoT yang diharapkan dapat memantau perkembangan bibit tanaman tomat secara berkala dan mengantisipasi bibit yang belum tumbuh. Pemantauan lingkungan pada bibit menggunakan sensor DHT11 untuk mendeteksi suhu dan kelembapan udara. Sensor LDR untuk mendeteksi intensitas cahaya. Kipas angin DC dan module mist spray fog maker untuk mengontrol keadaan suhu dan kelembapan udara pada tempat pembibitan. Pemantauan dengan computer vision menggunaan algoritma YOLOV8 untuk mendeteksi perkembangan bibit antara tumbuh dan belum tumbuh. Pengambilan data pengukuran dilakukan selama rentang waktu 10 hari. Hasil semua data pengukuran dikirim ke database dengan API, kemudian data tersebut ditampilkan melalui website. Perkembangan bibit tanaman tomat menggunakan sistem lebih cepat 1 hari daripada tidak menggunakan sistem. Pemantauan perkembangan bibit menggunakan YOLOV8 memiliki tingkat akurasi sebesar 96% yang berarti sistem dapat membedakan bibit yang tumbuh dan belum tumbuh.Â
Analisis Keluaran Berkas Radiasi Sinar-X pada Pesawat Linear Accelerator (LINAC) Berdasarkan TRS 398 IAEA di RSUD Arifin Achmad Provinsi Riau
Authors: Cahyaningtyas Saphira Indah , Anggraini Rista Mutia , Fendriani Yoza
Published: March 2024

Telah dilakukan penelitian tentang analisis keluaran berkas radiasi sinar-X pada pesawat Linear Accelerator (Linac). Analisis ini bertujuan untuk mengetahui keluaran berkas radiasi pada pesawat Linac menunjukkan nilai 1 cGy atau sama dengan 1 MU, yang diperoleh dari analisis ionisasi chamber, suhu, tekanan, efek polaritas, dan rekombinasi ion. Penelitian ini dilakukan menggunakan energi foton sebesar 6 MV dan energi elektron dengan variasi (4, 6, 8, 10, 12, dan 15) MeV. Luas lapangan yang digunakan yaitu 10 cm x 10 cm serta source to surface distance (SSD) 100 cm. Hasil analisis menunjukkan berkas energi foton 6 MV didapatkan nilai keluaran per 1 MU sebesar 1,0046 cGy/MU dengan deviasi 0,46%. Sedangkan pada berkas elektron energi 4 MeV sebesar 1,0112 cGy/MU dengan deviasi 1,12%, energi 6 MeV sebesar 1,0064 cGy/MU dengan deviasi 0,64%, energi 8 MeV sebesar 0,9991 cGy/MU dengan deviasi 0,09%, energi 10 MeV sebesar 0,9987 cGy/MU denganÂ  deviasi 0,13%, energi 12 MeV sebesar 0,9978 dengan deviasi 0,22% dan energi 15 MeV sebesar 1,0013 cGy/MU dengan deviasi 0,13%. Dalam hal ini keluaran berkas radiasi sinar-X pada pesawat Linac (Linear Accelerator) di RSUD Arifin Achmad Provinsi Riau telah sesuai dengan standar TRS 398 IAEA dengan rentang deviasi pengukuran yaitu Â±3%.
ANALYSIS OF THE IMPACT OF THE TRANSITION OF PSAK 44 TO PSAK 72 ON FINANCIAL STATEMENTS AT PT. LIPPO CIKARANG TBK
Authors: Rika Mala Sari  , Mutumanikam Primadonna Ratna
Published: March 2024

Sektor industri konstruksi, telekomunikasi, ritel, manufaktur dan real estate merupakan sektor yang terdampak atas penerapan PSAK 72 yang mengacu pada IFRS 15 sebagai ganti PSAK 44. Transaksi yang terkena dampak yang cukup besar dari standar baru ini adalah transaksi produk gabungan atau kontrak jangka panjang yang ada pada perusahaan real estate. Tujuan dari penelitian ini adalah menganalisis dampak transisi perubahan standar dari PSAK 44 menjadi PSAK 72 pada laporan keuangan PT Lippo Cikarang Tbk. Metode yang digunakan dalam penelitian kualitatif ini adalah metode deskriptif. Data yang digunakan laporan keuangan tahun 2020 PT Lippo Cikarang Tbk yang diambil dari website www.idx.com. Hasil penelitian ini menunjukkan bahwa akun piutang usaha, persediaan, pajak dibayar dimuka, liabilitas kontrak, pendapatan usaha dan beban pokok penjualan adalah akun yang terdampak dari perubahan PSAK 44 ke PSAK 72. Sebelum adanya kewajiban transisi PSAK 72 di tanggal 1 Januari 2020, PT Lippo Cikarang Tbk telah lebih dahulu menerapkan PSAK 44 sesuai dengan standar yang berlaku.
DETERMINANTS OF COMPANY SIZE, LEVERAGE, PROFITABILITY, ON CARBON EMISSION DISCLOSURE
Authors: Sindy Winni , Leniwati Driana , Prasetyo Nugroho Wicaksono3 Agung , Trisakti Agustin Dwi Haryanti
Published: March 2024

This research aims to test the influence of company size, leverage, profitability on carbon emission disclosure. This research uses mining companies listed on the Indonesia Stock Exchange during 2020. This research method uses a quantitative - associative design with secondary data sources, namely financial reports. There are 31 observation data. The analysis technique used is multiple linear regression with independent variables, namely company size, leverage, profitability and carbon emission disclosure as the dependent variable. The research results show that leverage has an effect on carbon emission disclosure. As for company size, profitability has no effect on carbon emission disclosure.
PENGARUH JUMLAH PENDUDUK DAN PDRB TERHADAP KEMISKINAN: ZAKAT SEBAGAI MODERASI
Authors: Amran Ellyana , Parinduri Aina Zahra
Published: March 2024

Analyzing the impact of population and GRDP on poverty in DKI Jakarta with Zakat as a moderating variable. The research method is a quantitative method with a saturated sample, that is, all members of the population are used as samples. The data source is secondary data with a panel model. The data analysis technique used is multiple regression with moderation variables and using the SPSS application. There is an effect of population on poverty rate; there is an effect of GRDP on poverty rate; zakat cannot moderate the effect of population on poverty rate; zakat cannot moderate the effect of GRDP on poverty rate.
ANALYSIS OF THE EFFECTIVENESS OF THE MONETARY POLICY TRANSMISSION CHANNEL IN INDONESIA WITH A SINGLE TARGET OF INFLATION FOR THE PERIOD 2016:08 - 2022:12
Authors: Fadilah Putri , Kusumastuti Sri Yani
Published: March 2024

The purpose of this study is to determine The Monetary Policy Transmission Channel In Indonesia With A Single Target of Inflation For The Period 2016:08 - 2022:12. The research method used the Vector Error Correction Model (VECM) for the period August 2016 until December 2022. This study uses secondary data from the Indonesian Central Statistics Agency (BPS) and CEIC (a company providing financial and macroeconomic indicator data). The results of this study show that inflation responses to the shock of variables in the Monetary Channel, Interest Rate Channel, and Inflation Expectation Channel is not very much. Viewed from the result of the Impulse Response Test and Variance Decomposition, the three channels for monetary policy transmission (monetary channel, interest rate channel, and expectation channel) must be more effectively implemented in Monetary Policy decision-making in Indonesia. The interest rate channel is the most effective channel among the three channels. The results of the Impulse Response test and Variance Decomposition prove that inflation responses to the shock of variables in the Interest Rate channel are the strongest and have the least time lag and variance of those variables. The most suitable variable used for an operational target in an interest rate channel is BI-7-Days-Repo-Rate (BI7DR). Based on comparation of the other two variables (deposit rate and interbank money market rate), the results of the Impulse Response test and Variance Decomposition show that BI7DR shock obtains strong and quick inflation responses.
SYSTEM-STRUCTURAL ASPECT OF THE SELECTIONELEMENTS OF ROBOTIC SYSTEMS
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kravets Volodymyr , Kravets Oleksandr ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Lapkovsky Serhii ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Frolov Volodymyr ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Gladskyi Maksym ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Danylova Liudmyla ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”
Published: March 2024

The article is devoted to solving the problems of technological preparation of robotic production. Currently, the creation of robotic systems has acquired the status of a completely independent technological task, which is solved on the basis of a significant reduction in the terms of technological preparation of production and the creation of fundamentally new software and technical tools. The growth of technical equipment and the technical integration of production processes under the conditions of robotization, which is related to this, have a significant impact on the selection criteria of individual structural elements of robotic systems. In contrast to the created traditional production systems, in which the main structural elementsimplemented in the relevant design and technological solutions were only machine tools, technological equipment and cutting tools, in robotic systems the range of structural elements is significantly expanded: the robotic systems, in addition to thespecified structural elements, contain technical means of control, industrial robots, transport equipment, technical means of storage, etc. It is quite obvious that now the methodology of creating robotic systems should go beyond solving only technical problems and should include a comprehensive and deep study of technology, management and organization, which are not only interdependent with related technical problems, but also directly affect their correct solution. The analysis of the latest researches and publications, which were devoted to the robotization of production, allows us to conclude that the problem of solving the taskof a justified choice of structural elements of robotic systems is currently not formalized and not solved. The article offers methodological bases for the formalization of the process of selecting structural elements of robotic systems, taking into account the specific limitations and production conditions. The proposed methodology makes it possible to systematically cover not only all technical solutions already existing in production, but also to find those, the creation of which is possible and, in some cases, even expedient; find existing technical solutions that are already implemented directly in production or that are provided with technical documentation, which will help minimize search time and prompt selection of ready-made solutions.
Языковые ландшафты Кызыла и Улан-Удэ как зеркало региональной языковой политики
Authors: Хилханова Эржен Владимировна , Ондар Чойган Геннадиевич , Иванов Вячеслав Валерьевич , Акопян Карен Суренович
Published: March 2024

Статья посвящена сопоставительному изучению языковых ландшафтов Кызыла и Улан-Удэ и функционированию в них государственных языков Тувы и Бурятии. В основу данной работы легла смешанная методология, включающая анализ официальных документов, регламентирующих языковую политику в обеих республиках, анализ визуальной текстовой информации (вывесок, табличек, объявлений государственных учреждений и частных организаций и т. д.). Информация была собрана методом сплошной фиксации в центральных и окраинных районах столиц обеих республик.
Анализ показал доминирование русского языка и второстепенность тувинского и бурятского языков в языковых ландшафтах. Это видно как в малой количественной представленности последних, так и в характере оформления — меньшем размере надписей, расположении и т. д. Зафиксированы также нарушения законов о языках Республик Тыва и Бурятия, орфографические и прочие ошибки в надписях на тувинском и бурятском языках. Выявлено, что в Кызыле нет разницы между языковым ландшафтом центральных и периферийных улиц, а в Улан-Удэ прописанное в законе двуязычие языкового ландшафта наблюдается преимущественно в центре города. Это объясняется и большей концентрацией в центре государственных учреждений, достопримечательностей и объектов культуры, старающихся соблюсти требования закона, и стратегиями владельцев частных бизнесов, стремящихся извлечь выгоду из национальных брендов республики, национальной кухни.
Выявленные сходства характерны не только для Кызыла и Улан-Удэ, но и для столиц других национальных республик России. Туристический, экономический и идентификационный потенциал языковых ландшафтов еще ждет своего осознания. В настоящий момент «нивелированные» языковые ландшафты не отражают в должной мере культурное и языковое своеобразие многонациональной страны и не «работают» на туристическую привлекательность исследованных регионов.
Rifampicin-induced thrombocytopenia in a patient with abdominal tuberculosis
Authors: Boddu Revanth , Sharma Anish , Mishra Kundan , Kumar Suman
Published: March 2024

Most anti-tubercular drugs are relatively safe, but adverse reactions are not uncommon. Rifampicin is one of the most effective and widely used anti-tuberculosis drugs. Adverse effects due to rifampicin are not uncommon and the patients usually have skin rash, gastrointestinal disturbances, and hepatotoxicity. Rarely, the patients may also have allergic and autoimmune manifestations, which may include life-threatening thrombocytopenia. A high index of suspicion and careful evaluation for temporal association with the suspected drug are required to diagnose drug-induced immune thrombocytopenia. We present a case of rifampicin-induced thrombocytopenia; though relatively rare, it needs attention.
A comparative study of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in bipolar mania and schizophrenia
Authors: Goyal Manish Kumar , Yadav Kuldeep Singh , Solanki Ram Kumar
Published: March 2024

Objectives

The role of immunological disturbance in bipolar disorder (BD) and schizophrenia has been highlighted by some studies. There are few studies available that compared the inflammatory markers between schizophrenia and BD, but only one study demonstrated the difference in terms of neutrophil/lymphocyte ratio (NLR) and Platelet/lymphocyte ratio (PLR) between them. So this study was conducted to compare the NLR and PLR values among schizophrenia, bipolar mania, and healthy controls in order to find out a potential biomarker for these disorders.

Material and Methods

Eighty consecutive patients suffering from bipolar mania, 80 suffering from schizophrenia, and 80 healthy controls were recruited in the psychiatric center situated at a tertiary care hospital. Blood samples of all groups were transferred to the laboratory for complete blood count analysis. Thereafter, all the groups were compared by applying proper statistics.

Results

Significant higher level of neutrophil count and NLR value was seen in both bipolar mania and schizophrenia groups compared to healthy controls. There was no difference observed between schizophrenia and the bipolar mania group regarding NLR, PLR, neutrophils, lymphocytes, and platelets values.

Conclusion

NLR has appeared as a potential marker in our study, and it reflects a state of low-grade inflammation in both schizophrenia and bipolar mania. BD and schizophrenia have been considered as part of one continuum, which is also supported by the findings of our study. These markers can help in the prognosis and treatment of at least a subsection of patients and also are inexpensive and easy to assess.
ФИЗИЧЕСКАЯ МОДЕЛЬ ПРЯМОГО ПЛОСКОГО УДАРА О МНОГОСЛОЙНУЮ ПОВЕРХНОСТЬ
Authors: Иванов И.В. , Джангиров Д.Г.
Published: March 2024

В статье рассмотрена модель прямого плоского упругого удара о поверхность твердого материала. В линейном приближении получена теоретическая зависимость для отношения сил в момент удара для однослойного и многослойного материалов. Проведенный эксперимент подтвердил эту зависимость для материалов с малым модулем упругости.
ИЗУЧЕНИЕ ФИТОХИМИЧЕСКОГО ПРОФИЛЯ И БИОЛОГИЧЕСКОЙ АКТИВНОСТИ ЭКСТРАКТОВ АСЕПТИЧЕСКИХ РАСТЕНИЙ HETERANTHERA ZOSTERIFOLIA MART.
Authors: Карачинский Ю.А. , Хлебникова Д.А. , Чередниченко М.Ю.
Published: March 2024

Объектом исследования являлось однодольное травянистое водное субтропическое растение гетерантера остролистная (Heteranthera zosterifolia Mart.). Цель исследования - оценка потенциала H. zosterifolia, культивируемой в условиях in vitro, как сырья для фармацевтической, легкой или пищевой промышленности. Методы и методология исследования — колориметрические методы количественного определения и качественные реакции, основанные на физических свойствах отдельных групп вторичных метаболитов. Результаты работы и их новизна — впервые изучен фитохимический профиль асептических растений H. zosterifolia и биологическая активность этанольного экстракта в отношении ряда фитопатогенных грибов. Область применения результатов—установленный спектр вторичных метаболитов обладает потенциалом использования в официнальной медицине и фармацевтике. Значимость работы — выявлен потенциал расширения спектра использования водного растения H. zosterifolia.
ПРОБЛЕМЫ РАННЕЙ ДИАГНОСТИКИ МУКОВИСЦИДОЗА
Authors: Аюпова Г.Р. , Аглетдинов Э.Ф. , Хусаинова Р.И.
Published: March 2024

Успешное развитие генной терапии муковисцидоза (МВ) невозможно без ранней и точной диагностики заболевания с определением конкретного молекулярного дефекта для назначения таргентных препаратов, однако существуют проблемы постановки диагноза с подтверждающей ДНК-диагностикой. Цель исследования: Обобщение и мониторинг результатов диагностики МВ в Республике Башкортостан (РБ) до и после введения массового неонатального скрининга, анализ результатов молекулярногенетических исследований и клинических случаев заболевания. Материалы и методы исследования: Проведен ретроспективный сравнительный анализ медицинских данных пациентов с МВ из РБ, выявленных до внедрения массового неонатального скрининга (до 2006г.) и за период с 2006 по 2022 гг. с применением неонатального скрининга. Выборка для молекулярно-генетического исследования составляла 300 человек. Для проведения ДНК-диагностики использована технология массового параллельного секвенирования (NGS) на платформе Illumina (MiSeq) с валидацией результатов секвенированием по Сенгеру. Результаты: Установлено, что средний возраст постановки диагноза МВ в доскрининговый период в РБ - 8 лет 8 мес., а в период с 2006 2022 гг.. - 3 года 11 мес. Но неонатальный скрининг не позволяет выявить всех пациентов, поэтому важно сохранение настороженности у врачей при выявлении у пациентов клиники МВ, так как есть формы заболевания с поздней манифестацией и мягким течением. Только ДНК - диагностика позволяет установить точный диагноз МВ. По результатам молекулярно-генетического исследования диагноз МВ подтвержден 94 пациентам, идентифицированы региональные особенности - 12 вариантов в гене CFTR с суммарной частотой 84,5%: Phe508del, E92K, CFTRdele2,3, 3849+10kbC>T, L138ins, G509D, 394delTT, N1303K, W1282X, Y84X, 2143delT, 1525-1G>A, частота комплексного аллеля c.1399C>T(p.Leu467Phe, L467F) - 16,6 %, что позволило оптимизировать алгоритмы диагностики и лечения МВ в РБ. Заключение: Клинические наблюдения и научные исследования доказывают, что решающим действием в комплексе медико-генетического консультирования при МВ является своевременно проведенная ДНК-диагностика.
ЭНТРОПИЯ В ХИМИЧЕСКОЙ КИНЕТИКЕ И ФИЗИКЕ
Authors: Кораблев Г.А.
Published: March 2024

Энторопийные принципы дают базисную основу формирования функциональных связей между многими величинами химической кинетики. Равновесная сумма энтропийных составляющих универсальной газовой постоянной равная R/2, имеет прямую математическую связь с тангенсом геодезического угла. Аналогичное соотношение этого параметра получено по графикам Аррениуса зависимости коэффициента скорости реакции от температуры. При движении в одном формате двух энтропийных составляющих равновесная сумма их энергий равна половине первоначальной величины энергии. Установленные принципы проявляются и в других закономерностях физико-химии, например по энергии активации в диффузионных процессах и в уравнении кинетической энергии.
A Cross Sectional Study to Investigate Work Satisfaction among Nurses: The Impact of Occupational Features
Authors:   General Hospital of Thoracic Diseases SOTIRIA, Athens, and Hellenic Open University, School of Social Sciences, Patra, Greece, Theofilou Paraskevi
Published: March 2024

The aim of the present study was to investigate work satisfaction among nurses as well as the impact of occupational features. A hundred and fifty two nurses (28 men and 124 women) participated in the survey. To collect the data, Job Satisfaction Survey (JSS) was used. There were statistically significant differences between the positions regarding satisfaction (total score) (p<0.05) with those nurses who had a position of responsibility (supervisors) showing the greatest satisfaction (p<0.05). Also, there were statistically significant differences between hours regarding satisfaction (dimensions) (p<0.05) with those nurses who had morning work showing the highest satisfaction (p<0.05) in the salary dimension. An effect on the level of satisfaction of the nursing staff is observed from the factors of years of service, position of responsibility, working hours and monthly salaries.
Development Status of Internet Hospitals in China
Authors:   Medical College of China Three Gorges University, China, Liang Licheng , Liang Liang ,   Department of Ophthalmology, Yichang Central People’s Hospital, The first college of Clinical Medical Science, China Three Gorges University, China
Published: March 2024

Internet hospitals are the deep integration of Internet, information technology and medical services. Driven by new technologies such as mobile Internet, cloud computing, big data, and the Internet of Things, the era of “Internet plus+medical care” is emerging. In December 2015, the first Chinese Internet hospital, Wuzhen Internet Hospital, was launched, and public health emergencies have catalyzed the development of “Internet plus medicine”. The emergence of Internet hospitals is a great progress in the process of medical reform, and an important transition from networked hospitals to smart hospitals. How Internet hospitals play their value to share the livelihood problem of “difficult to see a doctor” has become a hot social concern. Based on the common Internet hospitals, this paper analyzes the current development situation of China’s Internet hospitals, analyzes the difficulties and challenges they face, and discusses the future development direction.
Research Progress on Animal Models of Diabetes Mellitus
Authors:   School of Basic Medical, Guizhou University of Traditional Chinese Medicine, China, Zhang Nannan , Zhu Yi ,   College of Pharmacy, Guizhou University of Traditional Chinese Medicine, China, Huang Cong ,   School of Basic Medical, Guizhou University of Traditional Chinese Medicine, China, Li Jun ,   School of Basic Medical, Guizhou University of Traditional Chinese Medicine, China
Published: March 2024

Diabetes Mellitus (DM) is a complicated metabolic illness defined by hyperglycemia due to faulty insulin production or activity, and it is one of the world’s fastest-growing public health concerns. The construction of a good diabetes mellitus model is crucial for diabetes mellitus pathophysiology research, diabetic mellitus prevention, and the development of effective therapeutic therapy. Diabetes mellitus models are now chemically induced, spontaneous, and genetically created. The models were created using the chemical induction of streptozotocin and alloxan, and the spontaneous type of diabetes mellitus animal models are appropriate for T1DM, T2DM, and related phenotypes, including obesity and insulin resistance. Genetically engineered animal models are much more closely related to human diabetes mellitus, including gene knockout animal models. They can be used to explain the cause of diabetes mellitus in terms of molecular mechanisms and to study the effects of individual genes on insulin secretion and insulin resistance faultlessly. This research provides a detailed description of T1DM and T2DM animal models, illustrating the importance of diabetes mellitus.
On analytical corrections for restraints in absolute binding free energy calculations
Authors: Boresch Stefan
Published: March 2024

Double decoupling absolute binding free energy simulations require an intermediate state at which the ligand is held solely by restraints in a position and orientation resembling the bound state. One possible choice consists of one distance, two angle and three dihedral angle restraints. Here, I demonstrate that in practically all cases, the analytical correction derived under the rigid rotator harmonic oscillator approximation is sufficient to account for the free energy of the restraint.
Unimolecular Chemiexcited Oxygenation of Pathogenic Amyloids
Authors: Umeda Hiroki , Suda Kayo , Yokogawa Daisuke , Kawashima Shigehiro A. , Mitsunuma Harunobu , Yamanashi Yuki , Kanai Motomu
Published: March 2024

Pathogenic protein aggregates, called amyloids, are etiological-ly relevant to various diseases, including neurodegenerative Alzheimer disease. Catalytic photooxygenation of amyloids, such as amyloid-β (Aβ), reduces their toxicity; however, the requirement for light irradiation may limit its utility in large animals, including humans, due to the low tissue permeability of light. Here, we report that Cypridina luciferin analogs, dmCLA-Cl and dmCLA-Br, promoted selective oxygenation of amyloids through chemiexcitation without external light irra-diation. Further structural optimization of dmCLA-Cl led to the identification of a derivative with a polar carboxylate functional group and low cellular toxicity: dmCLA-Cl-acid. dmCLA-Cl-acid promoted oxygenation of Aβ amyloid and reduced its cellular toxicity without photoirradiation. The chemiexcited oxygenation developed in this study may be an effective approach to neutralizing the toxicity of amyloids, which can accumulate deep inside the body, and treating amy-loidosis.
Heuristic Modeling of Material Properties in Nano/Angstrom-Scale Channels: Integrating Experimental Observations and MD Simulations
Authors: Mishra Himanshu , Garg Ashish
Published: March 2024

Nanofluidics, the study of fluids confined within nanoscale channels, holds immense potential for various applications. However, these fluids exhibit unique properties (density, viscosity, and slip length) that deviate from their bulk counterparts and critically impact flow dynamics. Understanding and characterizing these properties is essential for designing efficient nanofluidic systems. Traditionally, numerous models, often complex and disparate, have been used to describe these properties. The current abundance of models makes selecting the most suitable one for numerical simulations a challenging task. In this paper, we propose a simpler, unified framework: a single power-law model for each property such as for density $\displaystyle \rho(H)/\rho_o = 1+ m_1~H^{-n_1}$, viscosity $\displaystyle \eta(H)/\eta_o = 1+ m_2~H^{-n_2}$, and the slip length $\lambda(H) = \lambda_o + m_3~H^{-n_3}$ (where $m_1, m_2, m_3, n_1, n_2, n_3, \lambda_o$ are the free fitting parameters). This model effectively captures data from experiments and simulations, even where existing literature employed diverse models. A key advantage of our model lies in its mathematical properties. Continuity and a continuous derivative ensure seamless implementation into numerical simulations and theoretical predictions, leading to more understable, stable and accurate results. Additionally, the model adheres to physical principles, predicting convergence to bulk properties as channel size increases. Further this proposed unified power-law model for density, viscosity, and slip length compared to existing exponential models, offers flexibility where it captures non-linear relationships and diverse data curvatures. Interpretability with clear physical meaning for parameters. Adaptability to combine with other functions for complex phenomena. Simplicity for easy parameter estimation, model interpretation, and computations. Robustness and less sensitive to outliers and noise in data and with fewer parameters to easy relate to underlying physics and scaling-laws. Hence proposed model's simplicity, smoothness, physical validity and generality make it a significant heuristic model for efficient design and optimization of nanoscale devices using theory and simulations across a wide range of applications.
Engineering of conserved sequence motif 1 residues in halohydrin dehalogenase HheC simultaneously enhances activity, stability and enantioselectivity
Authors: Staar Sophie , Estévez-Gay Miquel , Kaspar Felix , Osuna Sílvia , Schallmey Anett
Published: March 2024

Halohydrin dehalogenases (HHDHs) are powerful enzymes for the asymmetric diversification of oxyfunctionalized synthons. They feature two characteristic sequence motifs that distinguish them from homologous short-chain dehydrogenases and reductases. Sequence motif 1, carrying a conserved threonine, glycine and a central aromatic residue, lines the nucleophile binding pocket of HHDHs. It could therefore impact nucleophile binding and presumably also activity of the enzymes. However, experimental evidence supporting this theory is largely missing. Herein, we systematically studied the mutability of the three conserved motif 1 residues as well as their resulting impact on enzyme activity, stability and selectivity in two model HHDHs: HheC from Agrobacterium radiobacter AD1 and HheG from Ilumatobacter coccineus. In both HheC and HheG, the conserved threonine and glycine only tolerated mutations to structurally similar amino acids. In contrast, the central aromatic (i.e., phenylalanine or tyrosine) residue of motif 1 demonstrated much higher variability in HheC. Remarkably, some of these variants featured drastically altered activity, stability and selectivity characteristics. For instance, variant HheC F12Y displayed up to 5-fold increased specific activity in various epoxide ring opening and dehalogenation reactions as well as enhanced enantioselectivity (e.g., an E-value of 74 in the azidolysis of epichlorohydrin compared to E = 22 for HheC wild type), while exhibiting also a 10 K higher apparent melting temperature. QM and MD simulations support the experimentally observed activity increase of HheC F12Y and revealed alterations in the hydrogen bonding network within the active site. As such, our results demonstrate that multiple enzyme properties of HHDHs can be altered through targeted mutagenesis of conserved motif 1 residues. In addition, this work illustrates that motif 1 plays vital roles beyond nucleophile binding by impacting solubility and stability properties. These insights advance our understanding of HHDH active sites and will facilitate their future engineering.
Scalable Synthesis of TiO2@IrOx Core-Shell Catalyst for Proton Exchange Membrane Water Electrolysis with Low Iridium Loading
Authors: Hoffmeister Darius , Finger Selina , Fiedler Lena , Ma Tien-Ching , Körner Andreas , Zlatar Matej , Fritsch Birk , Witte-Bodnar Kerstin , Carl Simon , Götz Alexander , Apeleo Zubiri Benjamin , Will Johannes , Spiecker Erdmann , Cherevko Serhiy , Freiberg Anna T. S. , Mayrhofer Karl J. J. , Thiele Simon , Hutzler Andreas , Van Pham Chuyen
Published: March 2024

The widespread application of green hydrogen production technologies requires cost reduction of crucial elements. To achieve this, a viable pathway to reduce the iridium loading in proton exchange membrane water electrolysis (PEMWE) is explored. Herein, we present a scalable synthesis method based on a photodeposition process for a TiO2@IrOx core-shell catalyst with a reduced iridium content as low as 40 wt%. Using this synthesis route, we obtain titania support particles homogeneously coated with a thin iridium oxide shell of only 2.1 ± 0.4 nm. The catalyst exhibits not only high ex situ activity, but also decent stability compared to commercially available catalysts. Furthermore, the unique core-shell structure provides a threefold increased electrical powder conductivity compared to structures without the shell. In addition, the low iridium content facilitates the fabrication of sufficiently thick catalyst layers at decreased iridium loadings mitigating the impact of crack formation in the catalyst layer during PEMWE operation. We demonstrate that the novel TiO2@IrOx core-shell catalyst clearly outperforms the commercial reference in single-cell tests with an iridium loading below 0.3 mgIr cm 2 exhibiting a superior iridium-specific power density of 17.9 kW gIr-1 compared to 10.4 kW gIr-1 for the commercial reference.
Hypothesis of Concerted Reactivity of Singlet Non-Covalent Radical Dimers
Authors: Molev Gregory
Published: March 2024

This work explores the intriguing domain of Frustrated Radical Pairs (FRPs) and their potential to form non-covalent dimers, termed Entangled Radical Pairs (ERPs), which exhibit unique singlet ground states and potential concerted reactivity, differing from traditional stepwise reactions. A few recent publications showed that in certain cases when two radicals cannot form a covalent bond, they unexpectedly form a non-covalent dimer with a singlet ground state. This potentially opens a new elusive route of FRPs’ reactivity, in which both radicals react simultaneously as one molecule. Here, we review several published articles, in which such reactivity probably took place, but was overlooked. The idea presented in this proposal suggests a path towards many interesting reactions, such as low-temperature metal-free dehydrogenation of aliphatic hydrocarbons and others. Additionally, an alternative mechanism for the reactivity of Frustrated Lewis Pairs (FLPs) based on the ERP framework is proposed. Lastly, the implications of the ERP model on the general theory of chemical bond formation are contemplated, suggesting a revision of the traditional views on hybridization and electron entanglement. The manuscript calls for further experimental and theoretical investigations to substantiate the presented hypotheses, aiming to unlock new pathways in radical chemistry and beyond.
Self-reducing Precursors for Aluminium Metal Thin Films: Evaluation of Stable Aluminium Hydrides for Vapor Phase Aluminium Deposition
Authors: Huster Niklas , Mullins Rita , Nolan Michael , Devi Anjana
Published: March 2024

Thin films of Al as interconnect materials and those of AlN as wide bandgap semiconductor and piezoelectric material are of great interest for microelectronic applications. For the fabrication of these thin films via chemical vapor deposition (CVD) based routes, the available precursor library is rather limited, mostly comprising aluminium alkyls, chlorides, and few small amine-stabilized aluminium hydrides. Herein, we focused on rational precursor development for Al, their characterization and comparison to existing precursors comprising stabilized aluminium hydrides. We present and compare a series of potentially new and reported aluminium hydride precursors divided into three main groups with respect to their stabilization motive, and their systematic structural variation to evaluate the physicochemical properties. All compounds were comprehensively characterized by means of nuclear magnetic resonance spectroscopy (NMR), Fourier-transform infrared spectroscopy (FTIR), elemental analysis (EA), electron impact-mass spectrometry (EI-MS) and thermogravimetric analysis (TGA). Promising representatives were further evaluated as potential single source precursors for aluminium metal formation in proof-of-concept experiments. Structure and reaction enthalpies with NH3 or H2 as co-reactants were calculated via first principles density functional theory simulations and show the great potential as atomic layer deposition (ALD) precursors for Al and AlN thin films.
Successful reproduction of Hen Harrier Circus cyaneus in intensive arable farmland (central-east Belgium)
Authors: Feys Simon , Guelinckx Robin , Verdonckt Freek , Louette Gerald
Published: March 2024

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