bluuebunny/crossref_metadata_2025 huggingface dataset:
Cellular Interactions in the Human Fatty Liver
Authors: Sovaila Silvia ,   Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Craiova, Romania,   Silvia Sovaila, 2 Petru Rareş Street, 200349, Craiova, Romania, Phone: 0040753020253, E-mail: silvia.sovaila@internist.com, Purcarea Adrian ,   Internist.Ro Internal Medicine Clinic, Brasov, Romania, Gheonea Dan ,   Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Craiova, Romania, Ionescu Sanziana ,   First Surgical Clinic, Colentina University Hospital, Carol Davila Univeristy of Medicine and Pharmacy, Bucharest, Romania, Ciurea Tudorel ,   Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Craiova, Romania
Published: November 2022

Non-alcoholic steatohepatitis morbidity and mortality is on the rise due to the obesity pandemic. Its pathophysiology is not well understood and implies complex interactions between local hepatic cells populations, adipocytes, immune effectors that lead to hepatic lipid excess, lipotoxicity, cellular stress and inflammation, as well as programmed cell death. A better understanding of these pathogenic interactions would allow better identification of therapeutic targets in a disease that has no known pharmacological therapy until now.
A Case Report on the Use of Pharmacological Intervention in the Treatment of Diffuse Axonal Injury From Road Traffic Accidents
Authors: Previgliano Ignacio ,   Neurology Chair, Critical Care Course, Maimonides University, Buenos Aires, Argentina,   Ignacio Previgliano, Professor of Neurology, Maimonides University, Buenos Aires, Argentina, Email: iprevi@gmail.com, Phone: +5491149492625, Soto Marcela A. ,   Neurology Chair, Critical Care Course, Maimonides University, Buenos Aires, Argentina
Published: November 2022

We report a case of traumatic brain injury treated with Cerebrolysin, a neurorecovery stimulating agent. Our therapeutic approach was based on the pathophysiology of traumatic brain injury and, in particular, of diffuse axonal injury. The patient registered marked improvement in mood and cognitive performance, indicating the effectiveness of multimodal and multidisciplinary interventions after traumatic brain injury.
ANALISIS KINERJA ALGORITMA PEMILIHAN PENGGUNA DENGAN KOMPLEKSITAS RENDAH BERBASIS KOMBINASI ROUND-ROBIN PADA SISTEM MASSIVE MIMO
Authors: Nauvaldi Rayhan , Adriansyah Nachwan Mufti , Setiawan Dhoni Putra , Astuti Rina Pudji
Published: November 2022

Sistem komunikasi generasi kelima (5G) menuntut kinerja yang lebih tinggi dari generasi sebelumnya. Sistem Massive Multiple Input Multiple Output (MIMO) muncul sebagai solusi untuk mengatasi generasi sebelumnya yang tidak dapat memenuhi permintaan data dalam jumlah besar. Penggunaan Massive MIMO ini memungkinkan diciptakannya multiple beam sehingga throughput dapat meningkat lebih besar daripada generasi sebelumnya. Sistem Base Station (BS) dengan banyak antena tidak dapat melayani pengguna dalam jumlah besar secara bersamaan. Maka dari itu sangat penting untuk memilih layanan pengguna yang akan dilayani secara bersamaan dan menentukan jumlah optimal pengguna yang akan dilayani. Penelitian ni mengusulkan algoritma pemilihan layanan pengguna untuk mencapai spektral efisiensi tinggi dan interferensi kecil. Algoritma yang diusulkan adalah Capacity-Based User Selection, Frobenius Norm-Based User Selection, dan Chordal Distance User Selection (CDUS) yang dikombinasikan dengan algoritma Round-Robin (RR). Berdasarkan simulasi yang telah dilakukan, algoritma pemilihan layanan pengguna yang dikombinasikan dengan algoritma RR memberikan kinerja yang baik dalam hal sumrate menggunakan algoritma Capacity-RR dengan nilai 673 bps/Hz, tingkat fairness pada algoritma CDUS-RR memiliki indeks fairness dengan nilai rata-rata 3,29, dan kompleksitas pada algoritma CDUS-RR memiliki rata-rata runtime sebesar 0,62 detik. Hasil penelitian ini diharapkan dapat berkontribusi dalam pengembangan penjadwalan pengguna pada Massive MIMO.

Kata Kunci: : Massive MIMO, capacity-based user selection, frobenius norm-based user selection, chordal distance user selection, round-robin.
PENERAPAN METODE KENDALI CONTROL LYAPUNOV-BARRIER FUNCTION (CLBF) PADA MODEL QUADCOPTER
Authors: Cahyo Farhan Dwi , Romdlony Muhammad Zakiyullah , Rosa Muhammad Ridho
Published: November 2022

Penelitian ini melakukan penerapan metode kendali Control Lyapunov-Barrier Function (CLBF) pada model quadcopter menggunakan perangkat lunak Simulink. Kendali CLBF digunakan untuk menggerakkan model quadcopter dari posisi awal model ke posisi tujuan. Kendali CLBF juga berfungsi untuk menghindari unsafe states atau penghalang yang dimiliki oleh model quadcopter. Hasil penelitian ini menunjukkan bahwa penerapan kendali CLBF pada model quadcopter telah berhasil dilakukan. Percobaan model quadcopter menghasilkan nilai rata-rata galat sebesar 0,926% dan berhasil menghindari penghalang dengan rata-rata nilai terdekat terhadap penghalang sebesar 0,079 m.

Kata Kunci: control Lyapunov-barrier function, model quadcopter, simulasi
Covid-19, Public Violence, Fake News and Vaccines: A Theological Ethical Reflection
Authors: Lephakga Tshepo
Published: November 2022

This paper attempts to deal with Covid-19, fake news and vaccines and is the product of a talk the author gave at a contact session of the Northern Theological Seminary of the Uniting Reformed Church in Southern Africa. This presentation was given a few weeks after South Africans were confronted by the eruption of public violence, “apparently” sparked by the jailing of President Jacob Zuma. The author, although requested to share ideas on Covid-19 and vaccines, felt that there was some political nexus between public violence, the feeling of being left out systematically, the unintended consequences of the lockdown, and the spark—the Constitutional Court’s decision to jail the then president. This article does not discuss the Constitutional Court’s decision or the jailing of the then president but tries to academically think about the causes of the eruption of public violence. The author explores the politics surrounding the vaccines and the unintended consequences of the lockdown, discusses “what the Church has become” since the outbreak of this virus, and deliberates the impact of “fake-news” in the era of a pandemic.
Infecção respiratória de repetição em crianças: uma revisão de literatura
Authors: Aquino João Vitor Romão Neto Mury de , Oliveira Carla Resende Vaz , Siqueira Eithor Henrique , Santos Felipe de Souza , Weksler Guilherme Lima , Fernandes Luiz Felipe Alves , Reis Bruno Cezario Costa
Published: November 2022

Objetivo: Avaliar tratamentos existentes mais eficazes contra a infecção respiratória de repetição, para chegar a uma conclusão da melhor abordagem para esses casos. Métodos: Este trabalho fundamentalmente se propõe a realização de uma pesquisa bibliográfica com perspectiva qualitativa e descritiva no formato de revisão integrativa de literatura onde os dados do National Library of Medicine (PubMed), Biblioteca Virtual em Saúde (BVS) e Directory of Open Access Journals (DOAJ) foram utilizadas com descritores “Respiratory Tract Infections”, “Child” e “Recurrence”. Assim, como critérios de inclusão, texto completo, artigos em inglês, português, espanhol, estudo de incidência, ensaios clínicos controlados, ensaios clínicos, randomizados ou não, estudos de incidência e publicações de 2017 a 2022. Resultados: Após serem identificados os resultados e construído um quadro comparativo composto pelo número de indivíduos selecionados, ano publicado, queda das recidivas, autores e técnica ou medicamentos, encontrando que a vacinação com Streptococcus salivarius 24SMBc e Streptococcus oralis 89a e a dieta através de suplementação nutricional oral são os resultados encontrados para diminuição da recorrência. Considerações Finais: Assim, não existe um consenso do tratamento para infecções respiratórias recorrentes, necessitando da avaliação de cada caso para que minimize as chances de erro e não lesar os pacientes.
Impactos da Covid-19 na saúde mental da equipe de enfermagem de Unidades de Terapia Intensiva: uma revisão de escopo
Authors: Machado Carolina de Oliveira , Fonseca Jucielly Ferreira da , Salvador Pétala Tuani Candido de Oliveira , Dantas Eder Samuel Oliveira , Oliveira Lannuzya Veríssimo e
Published: November 2022

Objetivo: Identificar e mapear os impactos da Covid-19 na saúde mental da equipe de enfermagem de unidades de terapia intensiva. Métodos: Trata-se de uma revisão de escopo norteada pelo Joanna Briggs Institute Reviewers’ Manual. A coleta de dados ocorreu entre os meses novembro e dezembro de 2021, em sete bases de dados. A análise se deu por estatística descritiva simples. Resultados: Foram incluídos 16 estudos publicados nos anos de 2020 e 2021, provenientes de 12 países, com predominância de estudos advindos do continente europeu, tendo como principais áreas de conhecimento enfermagem, medicina e psicologia. Verificou-se que os principais impactos à saúde mental da equipe de enfermagem foram estresse, ansiedade e depressão. As estratégias predominantemente utilizadas para amenizar tais impactos foram intervenções psicológicas, fornecimento de treinamento adequado de biossegurança e orientações para identificação precoce dos sinais de adoecimento mental. Considerações finais: A saúde mental da equipe de enfermagem com atuação no cenário estudado sofreu diversos impactos, associados principalmente ao excesso de trabalho, escassez de equipamentos de proteção individuais e medo de infecção, deste modo, sugerem-se ações integrais de cuidado à saúde mental desta clientela.
Adult-Onset Still’s Disease with an Atypical Cutaneous Manifestation
Authors: Margulies Shae , Nagrani Nicole , Rodriguez-Waitkus Paul , Correa-Selm Lilia
Published: November 2022

Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder, characterized by daily fevers, arthralgias, and rash without evidence of infection. Recently there has been a growing number of cases reported with atypical cutaneous manifestations. We present a 37-year-old type VI Fitzpatrick skin type female who was seen in the hospital for a pruritic rash on her chest, back, and legs. Skin examination was significant for hyperpigmented papules coalescing into plaques on the chest, and hyperpigmented linear patches and excoriated plaques on the back and legs. Punch biopsy showed acanthosis and numerous apoptotic keratinocytes in the upper layers of the epidermis, which was characteristic of AOSD. As of recently, there is a growing body of evidence describing an atypical eruption of persistent, pruritic papules and plaques with typical histologic findings of AOSD. Further, these atypical features may be associated with more severe symptoms, higher incidence of macrophage activation syndrome, and possible delayed malignancy. Due to the scarcity of atypical cutaneous manifestations reported in the literature, these eruptions have not been included in the diagnostic criteria and can therefore be overlooked and misdiagnosed. Prompt recognition of these atypical eruptions is imperative to prevent a worsening prognosis and serious adverse effects.
A Case of Pseudoverrucous Papules and Nodules in an Adult with Spinal Dysraphism
Authors: Ugoh Gregory , Crain Caroline , Goodwin Brandon
Published: November 2022

Pseudoverrucous papules and nodules (PPN) occur in the setting of chronic
irritant contact dermatitis commonly due to urine or feces. PPN most commonly affects
infants but has also been reported in association with urostomies, colostomies, chronic
urinary incontinence, encopresis, chronic fecal incontinence, spinal cord injury, and
potentially spinal dysraphism. Herein, we present the case of a patient with spina bifida in
association with Dubowitz syndrome who presented with perianal PPN. To our
knowledge, there is only one other case reported in the literature of a patient with spina
bifida who presented with PPN.
Identifying Inflammatory Gene Expression Signatures for Skin and Soft Tissue Infections
Authors: Yeh Jennifer , Pereira da Silva Marcelo , Raff Adam , Foreman Ruth
Published: November 2022

Background: Misdiagnosis of skin and soft tissue infections (SSTIs) due to clinical mimics can result in delay of care, unnecessary antibiotic exposure, and inappropriate hospitalization. Comprehensive screening of inflammatory genes in SSTIs could identify biomarkers to distinguish SSTIs from mimics.
Methods: We performed a search of the MGH James Homer Wright Pathology Laboratories database from 2008-2018 for diagnoses of necrotizing fasciitis, cellulitis, and stasis dermatitis, yielding 103 cases. Diagnoses were verified by chart review and categorized by discharge diagnosis. Three samples from each category, along with three controls from location-matched skin were selected for further study. mRNA isolated from paraffin-embedded skin biopsies was analyzed by Nanostring, with 594 inflammatory genes profiled.
Results: We identified differentially expressed genes between necrotizing fasciitis, cellulitis, and infectious cases (necrotizing fasciitis and cellulitis) compared to non-infectious stasis dermatitis.  Differentially upregulated genes in SSTIs included those with known roles in inflammation (CXCR2, IL6, IFI16, TNFRSF1B) and transcriptional regulation (BCL3, MBP). We also identified differential upregulation of genes not previously associated with SSTIs including S100A8, S100A9, MCL1, CD14, and LTF.
Conclusions: We characterized transcriptomic signatures of severe and moderate SSTIs compared to stasis dermatitis and normal skin from the lower extremities. Though limited by small sample size, these data support the utility of a prospective study analyzing outcomes of patients diagnosed with SSTIs based on gene expression signatures. Identifying SSTI-specific gene expression signatures could help differentiate true skin infections from non-infectious inflammatory skin conditions, facilitating more accurate diagnoses and improving patient care.
The Integrated 31-Gene Expression Profile Test (i31-GEP) for Cutaneous Melanoma Outperforms the CP-GEP at Identifying Patients who can Forego Sentinel Lymph Node Biopsy when Applying NCCN Guidelines
Authors: Glazer Alex , Tassavor Michael , Portela Dustin , Soleymani Teo
Published: November 2022

Introduction: Eighty-eight percent of patients who receive a sentinel lymph node biopsy (SLNB) receive a negative result. Current guidelines suggest avoiding SLNB if the risk of positivity is <5%. A low threshold for performing SLNB indicates worry about missing positive nodes but results in many unnecessary biopsies. The integrated 31-gene expression profile (i31-GEP) test combines the 31-GEP with Breslow thickness, age, ulceration, and mitotic rate using a validated neural network algorithm to identify patients with <5% risk by reporting a precise, individualized likelihood score. Using logistic regression, a separate GEP (8 genes plus Breslow thickness and age; CP-GEP) also aims to identify patients who can forego SLNB by binning patients into low- and high-risk categories. This study compared the i31-GEP for SLNB with the CP-GEP to identify patients who can safely forego SLNB.
Methods: This study evaluated the genes, gene pathways, and relative contribution of the two gene signatures relative to clinical and pathologic factors and further analyzed patients with T1b-T2 tumors from previously published studies in U.S. cohorts for the i31-GEP (n=763) and CP-GEP (n=153). A ratio of true-to-false-negative i31-GEP for SLNB and CP-GEP test results was compared to the guideline-established ratio of 19 negatives to one missed positive (19:1) if foregoing SLNB using a 5% risk threshold.
Results: The i31-GEP had a 30:1 true-to-false-negative ratio, compared to 15:1 using CP-GEP. In T1b tumors, the i31-GEP ratio increased to 35:1 compared to 14:1 using CP-GEP.
Limitations: Retrospective design, which could lead to bias. Patients included in both analyses were primarily from institutional surgical centers, and referral bias may not make the result generalizable.
Conclusion: Only the i31-GEP provided benefit over guideline-established care for identifying patients with low risk of SLN positivity.
Deucravacitinib in plaque psoriasis: 2-year laboratory results from the phase 3 POETYK PSO program
Authors: Korman Neil , Passeron Thierry , Gordon Kenneth , Okubo Yukari , Bagel Jerry , Sofen Howard , Warren Richard , Bhatia Neal , Spelman Lynda , Winthrop Kevin , Hippeli Lauren , Kisa Renata , Banerjee Subhashis , Thaçi Diamant
Published: November 2022

N/A
Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in moderate to severe plaque psoriasis: correlations between patient-reported outcomes and clinical responses in the phase 3 clinical trials POETYK PSO-1 and POETYK PSO-2
Authors: Armstrong April W , Papp Kim A , Zhuo Joe , Becker Brandon , Zhong Yichen , Beaumont Jennifer L , DeRosa Michael , Kisa Renata M , Banerjee Subhashis , Strober Bruce
Published: November 2022

N/A
Bimekizumab maintenance of response through three years in patients with moderate to severe plaque psoriasis who responded at Week 16: Results from the BE BRIGHT open-label extension trial
Authors: Strober Bruce , Tada Yayoi , Mrowietz Ulrich , Lebwohl Mark , Foley Peter , Langley Richard G , Barker Jonathan , Wang Maggie , Vanvoorden Veerle , Szilagyi Balint , Ciaravino Valerie , Paul Carle
Published: November 2022

N/A
DIAGNOSTIC PERFORMANCE OF 18F-PSMA-1007 PET/CT FOR THE DETECTION OF METASTASES IN PATIENTS WITH NEWLY DIAGNOSED PROSTATE CANCER
Authors:   N. N. Alexandrov National Cancer Centre, Lesnoy, Belarus, Polyakov S. L. , Paddubny K. V. ,   N. N. Alexandrov National Cancer Centre, Lesnoy, Belarus, Dziameshka P. D. ,   N. N. Alexandrov National Cancer Centre, Lesnoy, Belarus, Sinaika V. V. ,   N. N. Alexandrov National Cancer Centre, Lesnoy, Belarus, Krasny S. A. ,   N. N. Alexandrov National Cancer Centre, Lesnoy, Belarus
Published: November 2022

Introduction. The initial detection of regional and/or distant metastases in patients with newly diagnosed prostate cancer (PCa) is important for the management and disease prognosis. Conventional diagnostic imaging methods have certain limitations and do not allow a comprehensive assessment of the tumor spread. In recent years the use of positron emission tomography combined with computed tomography (PET/CT) with ligands of the prostate-specific membrane antigen (PSMA) has been rapidly expanding in oncological practice. The aim of the study was to analyze the diagnostic performance of 18F-PSMA-1007 PET/CT for the detection of metastases in patients with newly diagnosed prostate cancer. Material and methods. The study included 52 patients with newly diagnosed high-risk PCa, who underwent 18F-PSMA-1007 PET/CT. In all patients, there were no regional and/or distant metastases according to results of conventional imaging methods (bone scan, computed (or magnetic resonance) tomography of the pelvis). The conclusion about the presence or absence of metastases was made based on pathomorphological verification (in 27 patients) or using all available imaging and clinical follow-up as a reference. Results. Of the 52 patients included in the analysis, 26 (50.0%) had PCa metastases. Of these, 25 (48.1% of total cases) patients had true positive 18F-PSMA-1007 PET/CT. False-positive findings occurred in 2 cases. The positive predictive value of the method was 96.1%. In a univariate analysis of factors associated with true-positive PET/CT results, only the T-stage and Gleason score demonstrated statistically significant predictive value (p<0.05). According to multivariate analysis, only the Gleason score was statistically significantly associated with true positive findings on 18F-PSMA-1007 PET/CT (p=0.03). The most unfavorable in terms of the risk of detecting metastases was the group of patients with a Gleason score 7 (4+3) -10 (metastasis rate was 62.2%). Conclusion. 18F-PSMA-1007 PET/CT is an informative method for the detection of metastases in patients with newly diagnosed high risk PCa. 18F-PSMA-1007 PET/CT may be recommended in patients with Gleason score 4+3 or higher due to the high probability of regional and/or distant metastases, which were not detected by conventional methods.
THE EFFECT OF BASSINI TENSION INGUINAL HERNIOPLASTY ON TESTICULAR VOLUME IN THE EARLY AND LONG – TERM POSTOPERATIVE PERIODS
Authors:   Grodno State Medical University, Grodno, Belarus, Novitskaya V. S.
Published: November 2022

Target. To assess the effect of Bassini inguinal hernioplasty on testicular volume in the early and late postoperative periods. Material and methods. Testicular volume before surgery was studied in 125 patients of various age groups. Inguinal hernia repair according to the Bassini method was performed in 30 patients who had their testicular volume determined by ultrasound in the early postoperative period and 1 year after surgery. Results. With inguinal hernias, the volume of the testicle on the side of the hernial protrusion depends on the age of the patient and does not differ from the volume of the testicle on the contralateral side. Tension inguinal hernioplasty according to Bassini in the early postoperative period is accompanied by an increase in the volume of the testicle, and in the late postoperative period by a decrease in its volume. Conclusion. Inguinal hernioplasty according to the Bassini technique in the late postoperative period leads to a decrease in the volume of the testicle on the side of the surgical intervention.
Remissão total da urticária crônica espontânea após o tratamento de infecção por Helicobacter pylori - relato de caso e revisão de literatura / Complete remission of spontaneous chronic urticaria after treatment of Helicobacter pylori infection - case report and literature review
Authors: Mello Mariana da Silva , Mantoku Victor  Akihiro Morishita , Manfredini Enrico , Arena Lucas de Carvalho , Dionigi Patrícia Cristina Loureiro , Forte Wilma  Carvalho Neves
Published: November 2022

Introdução: A urticária é um distúrbio de pele que atinge 15 a 20% dos indivíduos em alguma fase da vida. É classificada como urticária crônica espontânea (UCE) quando as manifestações são diárias ou quase diárias e ultrapassam seis semanas. É de fundamental importância a pesquisa da causa da UCE para o tratamento correto. Objetivo: Relatar caso de uma paciente que apresentou remissão total da UCE após tratamento de infecção por Helicobacter pylori e com exclusão clínico-laboratorial das diferentes causas de urticária crônica. Relato do caso: Mulher de 46 anos apresentava UCE há 15 meses, refratária ao tratamento com anti-histamínicos. Foram excluídas clínica e laboratorialmente diferentes causas da urticária crônica, como neoplasias, doenças autoimunes e infecciosas. Durante o acompanhamento revelou epigastralgia, quando foi solicitada endoscopia digestiva, que revelou pangastrite erosiva e presença de H. pylori. Recebeu então tratamento para infecção por H. pylori e apresentou remissão total da urticária. Estudos da literatura sugerem possível associação entre infecção por H. pylori e urticária crônica, e mais estudos são necessários. Conclusão: Os autores acreditam ser importante a investigação diagnóstica da infecção por H. pylori em pacientes com UCE e manifestações dispépticas, depois de excluir outras causas de urticária crônica, como neoplasias, doenças autoimunes e infecciosas.
Palavras Chave: Urticária crônica, Helicobacter pylori, Dor abdominal
NEW FORMAT OF THE UNIFIED STATE EXAM (BY THE EXAMPLE OF THE FRENCH LANGUAGE)
Authors: Григорьева Елена Яковлевна , Горбачева Екатерина Юрьевна
Published: November 2022

Проанализированы контрольные измерительные материалы российского единого государственного экзамена по французскому языку. Приведены примеры обновленных коммуникативных заданий, структура и содержание самого экзамена. Особое внимание уделяется изменениям, которые были внесены в разделы «Письмо» и «Говорение» экзаменационной работы 2022 года как на базовом, так и на повышенном уровне. В связи с новыми заданиями соответствующие изменения внесены и в критерии оценивания. Описаны типичные ошибки, приводящие к сбою в коммуникации и искажению смысла.

The control measuring materials of the Russian unified state exam in French are analyzed. Examples of updated communicative tasks, the structure and content of the exam itself, its basic and advanced levels are givn. Particular attention is paid to the changes that have been made to the Writing and Speaking sections of the 2022 exam paper at both the basic and advanced levels. In connection with the new tasks, the corresponding changes were made to the assessment criteria. Typical mistakes are described that lead to a failure in communication and distortion of meaning.
DEVELOPMENT OF TEACHERS’ PROFESSIONAL COMPETENCE IN THE FIELD OF COMPREHENSIVE SUPPORT OF CHILDREN WITH DISABILITIES: ORGANIZATIONAL AND METHODOLOGICAL ASPECTS
Authors: Васильева Надежда Николаевна
Published: November 2022

Рассмотрена проблема формирования профессиональной компетентности педагогов в области психолого-педагогического сопровождения детей с ограниченными возможностями здоровья (ОВЗ). В качестве методов исследования применены: изучение нормативно-правовых документов, регулирующих сферу образования; анализ современных тематических исследований; обобщение опыта подготовки педагогов и повышения их квалификации. Обозначены опорные точки модернизации теоретической и практической подготовки специалистов сопровождения детей с ОВЗ. Обсуждаются организационно-методические аспекты повышения профессиональной компетентности педагогов в сфере комплексного сопровождения детей с ОВЗ.

The article is devoted to the problem of formation of teachers’ professional competence teachers in the field of psychological and pedagogical support for children with disabilities. The following methods were used as research methods: the study of legal documents regulating the sphere of education; analysis of contemporary case studies and methods of teachers’ training. We indicate the key points for the modernization of the theoretical and practical training of specialists in accompanying children with disabilities. We also discuss organizational and methodological aspects of increasing teachers’ professional competence in the field of comprehensive support for children with disabilities.
THE LINGUOCULTUROLOGICAL ASPECT OF THE STUDY OF LANGUAGE UNITS IN TEACHING RUSSIAN AS A FOREIGN LANGUAGE
Authors: Парочкина Мария Михайловна , Воробьёва Галина Васильевна
Published: November 2022

Уточнена специфика лингвострановедческого подхода к анализу иноязычного учебного текста, рассмотрены некоторые особенности методической работы с его лингвокультурными компонентами. Подчеркивается важность выделения в методике преподавания русского языка как иностранного отдельной дисциплины - лингвострановедения, ставящего своей задачей развитие коммуникативной компетенции иностранного учащегося посредством приобщения к культуре страны изучаемого языка. Объектом исследования в статье выступает лингвострановедческий аспект изучения языковых единиц в процессе обучения РКИ, предметом является система работы с лингвострановедческим аспектом текста. Освещаются ведущие принципы лингвострановедения, перечисляются основные языковые единицы, находящиеся в фокусе внимания лингвострановедения. Рассматриваются виды лингвокультурных лакун, а также процесс их элиминации.

The purpose of the article is to clarify the specifics of the linguoculturological approach to the analysis of a foreign-language educational text, to consider some features of methodological work with its linguistic and cultural components. The authors emphasize the importance of separating a separate discipline from the general regional studies - linguistic and regional studies, the main task of which is the development of communicative competence through familiarization with a culture. The object of research in the article is the linguoculturological aspect of the study of language units in the process of teaching Russian as a foreign language, the subject is the system of work with the linguistic and cultural aspect of the text. The authors of the article highlight the leading principles of linguoculturology, list the main linguistic units that are in the focus of linguoculturology. The article discusses the types of linguistic and cultural gaps, as well as the process of their elimination.
STUDENTS' COGNITIVE AND COGNITIVE ACTIVITY IN THE PROCESS OF LEARNING A FOREIGN LANGUAGE USING LEARNING ROBOTS
Authors: Ван Шисянь
Published: November 2022

Анализируются актуальные исследования по изучению лексики, грамматики, чтения и аудирования на иностранных языках посредством образовательной робототехники. Рассмотрено влияние обучающих роботов на мотивацию учащихся, влияние новизны обучающих роботов на изучение иностранного языка и сложности социального поведения обучающих роботов. В итоге установлено, что содержание обучения с помощью роботов нацелено на активизацию познавательной деятельности учащихся и обладает значительным потенциалом для развития эмоциональных навыков, необходимых в процессе обучения.

Current research on the study of vocabulary, grammar, reading and listening in foreign languages through educational robotics is analyzed. The influence of teaching robots on the motivation of students, the impact of the novelty of teaching robots on learning a foreign language and the complexity of the social behavior of teaching robots are considered. Accordingly, it is discovered that robot-assisted learning content aims to stimulate students' cognitive functions and has a considerable potential for fostering the emotional abilities required for learning.
STUDY OF RESISTANCE TO INFORMATION PROVOCATIONS DURING PREPARATION FOR PERFORMANCE OF SERVICE AND COMBAT MISSIONS
Authors: Маклачков Егор Александрович
Published: November 2022

Современные геополитические вызовы актуализируют проблему негативного влияния информационных провокаций на общество. Решение данной проблемы становится особенно важным для военнослужащих и сотрудников войск национальной гвардии, выполняющих служебно-боевые задачи по охране правопорядка в стране. В целях развития устойчивости к информационным провокациям разработан и апробирован факультативный курс занятий. По окончании занятий проведена повторная диагностика. Анализ данных подтвердил качественные изменения состояния устойчивости к информационным провокациям у сотрудников, освоивших курс занятий.

Modern geopolitical challenges actualize the problem of the negative impact of information provocations on society. The solution to this problem is becoming especially important for military personnel and employees of the National Guard troops performing service and combat missions to protect law and order in the country. In order to develop resistance to information provocations, an optional course of classes was developed and tested. At the end of the classes, repeated diagnostics were carried out. The analysis of the data confirmed qualitative changes in the state of resistance to information provocations among employees who mastered the course of classes.
Effect of chronic marijuana use on cognition: A crosssectional study in urban Bengaluru
Authors: Vellal Sahana , Masthi N R Ramesh , Halkur Shankar Sujay
Published: November 2022

Background and Aim Cannabis or Marijuana is a psychoactive drug. It is one of the commonest recreational drug and the most common illegal drug across the globe. Aim of this study is to assess the cognitive effects of chronic cannabis use using the standardized Montreal Cognitive Assessment MoCA Test and contrast the sociodemographic profile between users and non-users.Materials and methods This was a cross-sectional study conducted in Urban Bengaluru India between July and September 2016. Male and female students aged between 18 and 25 years were included and grouped into Chronic cannabis user or a Control. The MoCA Test was then administered in the subjectrsquos preferred language and assessed based on the defined MoCA administration and grading standards.Results A total of 62 individuals were recruited. 31 individuals were grouped as cases and a matching 31 individualsrsquo controls. Each group comprised on 29 males and 2 females. There was a significant difference between the total score of the MoCA test in the chronic marijuana user group Median 25 when compared to the control group Median 28 U 181 p lt 0.001. Among the different categories of the MoCA tool there was a significant difference between the userrsquos group and the control group in the categories of Visuospatial function Attention and Language.Conclusion Chronic cannabis users were found to have cognitive impairment than those who have never used cannabis.
Kyasanur forest Disease: Real alarming illness in Western Ghats of India
Authors: Kumar R Mahendra , Deshpande Krishna , R Manasa , S Shwetha , Kotian Ankitha
Published: November 2022

A highly infectious tick-borne virus is causing Kyasanur Forest Disease KFD which has been spreading in India in recent decades. Kyasanur Forest Disease or Monkey fever is an emerging zoonotic viral tick-borne disease affecting mainly monkeys. It causes severe febrile illness in humans and was first recognized in Kyasanur Forest in 1957 associated with a high number of deaths among monkeys. Since then between 400 and 500 human cases are recorded annually It is caused by the Flaviviridae family KFD virus KFDV and is transmitted by Haemaphysalis ticks to monkeys and humans. In the transmission of KFDV human act as a dead-end host with no sufficient viremia for further transmission. A formalin inactivated tissue culture vaccine is available for prophylaxis. Although the available vaccine once successfully controlled the KFD the increasing trend of the disease over the last five years is alarming regardless of routine vaccination. In this paper a comprehensive endeavour has been made to review the Kysanur forest disease. This review seeks to raise awareness of this alarming disease so that individuals with KFD are identified and provided with appropriate care. Background In April 2020 reports in The Hindu Daily Newspaper of an on-going outbreak of Kyasanur forest disease KFD in Shivamogga district of Karnataka India the total number of 197 positive cases of KFD were seen in Karnataka since the beginning of the year. These reports serve as a reminder that KFD is a major public health issue in the region and that outbreaks occur at some frequency. Although KFD frequently occurs in its endemic area relatively little is known of its pathogenic mechanisms or the response of the host to infection. The aim of this article is to examine KFD lsquos history and highlight the importance of the disease and others linked to flavivirus.
Herpes Simplex Keratitis Corneal Perforation: A Case Report
Authors: Kulkarni Abhishek , Sangeeta Patil * , Chatnalli Anil , Saara Uzma
Published: November 2022

Infectious keratitis of bacterial and fungal etiology is an important cause of visual morbidity in developing countries. If untreated the visual outcome is guarded. Viral keratitis especially of the stromal variant if not treated aggressively with medical and surgical means is a potentially blinding condition. Keratoplasty remains the last resort to salvage such eyes from secondary complications and loss of the eye.
An overview of stem cells in dentistry
Authors: Yamini* Sriramula , Raghava Vijay , Yadalam Umesh , Bose Aditi , Pratim Roy Parth , Nambiar Manjusha
Published: November 2022

Stem cells are gaining much attention these days because of their self-renewal and differentiation properties. The development of tissue engineering in the last few decades aims to enhance the repair of damaged or lost tissues. Tissue engineering involves the use of engineering principles in the development of tissue or organ grafts. Tissue regeneration is achieved by the use of cells biomaterials and tissue-inducing factors in combinations or alone. The stem cells are capable substitute for many specialized cells or organs forming cells owing to their inherent potential of evolving into a spectrum of tissues. The main aim of this review article is to discuss the history of dental stem cells DSC isolation approaches collection and current status in dentistry.
Amyloid Cascade in Alzheimer’s Disease
Authors: P S Shankar
Published: November 2022

None
Cryogenic lithopotoks of the Munku-Sardyk mountain range
Authors:   Irkutsk State University, Kovalenko S.N. , Akulova U.V. ,   Irkutsk State University
Published: November 2022

The article deals with exogenous cryogenic relief-forming litopotoks: periglacial (supraglacial) zone, modern glacial zone; the thermal zone of paleoglacials of regressive stage, erosive or fluvial zone of proluvial, solifluction, high-altitude ice and permafrost-stone mountain streams.
Литотипы, фации и источники материала осадочных пород в Баргузинской долине Байкальской рифтовой системы
Authors:   Institute of the Earth's Crust SB RAS, Khassan A.I. ,   Irkutsk State University,   Al-Bass University, Rasskazov S.V. ,   Institute of the Earth's Crust SB RAS,   Irkutsk State University, Chuvashova I.S. ,   Institute of the Earth's Crust SB RAS,   Al-Bass University, Kornilova T.A. ,   Institute of the Earth's Crust SB RAS, Yasnygina T.A. ,   Institute of the Earth's Crust SB RAS
Published: November 2022

Lithological, petrographic, and lithogeochemical data are given for sedimentary rocks of alluvial, lacustrine-marsh, and lacustrine facies in the Barguzin valley, uncovered by new boreholes. During petrographic studies of thin sections, the main lithotypes of stratons of rift basins were identified. According to the mineral composition of the rocks, petrochemical and microelement characteristics, a conclusion was made about the origin of sedimentary deposits as a result of erosion of the granite basement rocks.
Relationship between petrological core-mantle transition and the seismic Moho discontinuty below granulite terranes: evidence on transformation of a root part beneath the Eastern Tunka block in deep-seated nodules from late ceniozoic volcanic rocks
Authors:   Institute of the Earth's Crust SB RAS, Rasskazov S.V. ,   Irkutsk State University, Ailow Yu. ,   Institute of the Earth's Crust SB RAS,   Al-Furat University, Chuvashova I.S. ,   Institute of the Earth's Crust SB RAS,   Irkutsk State University, Yasnygina T.A. ,   Institute of the Earth's Crust SB RAS
Published: November 2022

From compositions of garnet-bearing and garnet-free assemblages of deep-seated nodules brought to a surface by Cenozoic and older (Phanerozoic) magmatic melts, petrological zones of crust-mantle transition (PZСMT) are defined under granulite terranes of craton and non-craton regions. Present-day Moho discontinuities only partially coincide with petrological estimates of a change from felsic-basic rocks (that belong to the continental crust) by predominantly ultramafic rocks (that represent the continental mantle lithosphere) and often lie much deeper than the PZСMT. Depths of such zones change over time. For a garnet-free assemblage of deep-seated nodules ejected by basaltic melts about 13 Ma ago from the root of a granulite terrane exposed in the eastern part of the Tunka Valley, two PT trends were obtained, one of which corresponds to a high (up to 120 mW/m2) rift conductive geotherm, another one crosses low conductive geotherms (drops below 60 mW/m2 one). The PZСMT shows here a temperature approximately 200°C lower than the PZСMT of granulite terranes in Eastern Australia, China, and Svalbard. Deep-seated nodules characterize the development of hot transtension under the rift valley in the cold root part of the East Tunka block with the accumulation and release of elastic stresses accompanied by significant synkinematic (metasomatic and magmatic) processes in the time interval 18–12 Ma ago. The transtension was followed by a crustal transpression with inversional uplift of an area and a probable relative increase in the depth of the Moho discontinuity, determined from the both P- and S-wave velocities for the modern crust and lithospheric part of the mantle.
Scientific conference of students and young scientists on Earth sciences 2022, dedicated to the 60th anniversary of the first oil fountain
Authors:   Irkutsk State University, Kotovshchikova М.А.
Published: November 2022

On April 7, 2022, a scientific conference of students and young scientists on Earth sciences was held in the assembly hall of the ISU Faculty of Geology, dedicated to the 60th anniversary of the first oil fountain. The total number of participants exceeded 60 people, including one foreign graduate student of the Faculty of Geology.
Features of rupture formation in a rheologically heterogeneous sedimentary cover over active foundation faults: according to the results of physical modeling
Authors:   Institute of the Earth's Crust, Siberian Branch of RAS, Bornyakov S.A. , Primina S.P. ,   Irkutsk State University, Chubakova Yu.V. ,   Irkutsk State University
Published: November 2022

Physical modeling of the process of formation of the shear zone in single-layer and multilayer models of models is carried out in order to elucidate the features of fault formation in the rheologically heterogeneous sedimentary cover of the platform over the active fractures of the foundation. Model materials were montmorillonite clay water paste, wet sand and their composite. On the example of single-layer models, it is shown that the thickness of the deformable layer determines the width of the shear zone, the time of the onset of rupture formation in it and the duration of the implementation of the stages of its development, and its rheological properties determine the features of its internal discontinuous structure. The results of modeling on rheologically heterogeneous multilayer models showed that the width of the shear zone formed in them does not remain constant in vertical and is determined by the properties of the model material.
The value of the optic nerve sheath diameter measured using computerized brain tomography in the evaluation of mortality status in patients admitted to the emergency department with intracranial hemorrhage
Authors: Boran Nukhet Burçem , Karakaya Zeynep , Acar Hüseyin , Efgan Mehmet Göktuğ , Bilgin Serkan
Published: November 2022

Background/Aim: The optic nerve sheath diameter (ONSD) measurement is a non-invasive method that can be obtained from computerized tomography (CT) images. It can therefore be a useful diagnostic tool in determining prognosis in the emergency department. The aim of this study was to investigate the relationship between ONSD and mortality status in patients with intracranial hemorrhage who presented to the emergency department by measuring ONSD on computerized brain tomography images taken during admission.
Methods: This retrospective cohort study was carried out in the emergency department of a tertiary hospital between December 1, 2018 and December 1, 2020 and included intracranial hemorrhage patients and patients with normal brain CT scans that had been obtained for any reason. Bilateral ONSDs were measured in both the intracranial hemorrhage and control groups. We first evaluated whether ONSD would differ between the two groups after which the relationship between ONSD and mortality was analyzed in the patient group who presented with bleeding.
Results: Intracranial hemorrhage was present in half the cases and midline shift in 21.5%. A statistically significant increase in ONSD was observed in cases with intracranial hemorrhage (P < 0.001). Similarly, a statistically significant increase in ONSD was found in cases with midline shifts and mortality (P < 0.001). A cut-off value of 4.19 mm for mean optic nerve diameter exhibited 100% sensitivity and 70% specificity in terms of hemorrhage detection (area under the curve [AUC]: 0.952; P < 0.001). A cut-off value of 6.03 mm for ONSD exhibited 76% sensitivity and 74% specificity in terms of hemorrhage detection (AUC: 0.730; P = 0.001). The odds ratio for prediction of mortality based on a regression analysis was 8.838 in cases with intracranial hemorrhage (P < 0.001).
Conclusion: ONSSD measured on CT images is a promising tool for prediction of intracranial hemorrhage, midline shift, and mortality status.
A STUDY OF THE MARKET DEMAND OF MOBILE SMART HOUSE UNDER THE SMART CITY DEVELOPMENT BACKGROUND
Authors: YU Miao , BI Chuanchen
Published: November 2022

The smart city development is the tendency of China’s urban development. The implementation of smart city provides a guiding direction for the development and integration of the whole industry. The double carbon policy of carbon emissions peak and carbon neutrality is the primary goals in China’s energy transition and environmental protection in the coming decades. Mobile smart house can meet the needs of users in the mobile lifestyle, energy conservation, energy management, smart home and smart house, and support and promote the smart house policy and double carbon policy. Through the secondary data collection and literature analysis methods, the paper concludes that how mobile smart houses meet people’s needs in energy and information and analyzes the kind of free life that mobile smart houses can help people achieve. The SWOT method is used to analyze the advantages and disadvantages of mobile smart house, to provide solutions for the development direction of the mobile smart housing products and for the aim of better meeting the market demand.
Analisis Perilaku Generasi Digital Native Terhadap Bank Syariah
Authors: Ngali Fatkhul , Purwanto Purwanto , Fitriyani Yeny
Published: November 2022

The motive of this take a look at is to decide the elements that impact the goal of the virtual local technology to undertake Islamic banking offerings. Much preceding research have used the Theory of Planned Behaviour (TPB) withinside the adoption of the conduct of Islamic monetary offerings, however there are nonetheless few research withinside the context of the virtual local technology. Meanwhile, the virtual local technology can end up a marketplace phase for Islamic banking as a way to growth marketplace share. The studies pattern turned into 169 respondents from the virtual local technology who stay in Magelang Regency. The studies information turned into gathered on line the usage of the google shape facility. Data evaluation used Structural Equation Modelling primarily based totally on variance. The results show that theoretically, this research can prove that the Theory of Planned Behavior (TPB) is relevant to be used in analyzing the behavior of the digital native generation towards Islamic banks. Partially, this study proves that the variables in the TPB, namely attitudes, subjective norms and perceived behavioral control, were found to have a significant positive influence on the intention of the digital native generation to adopt Islamic banking services. The next finding is that online shopping behavior is able to moderate the relationship between subjective norms and behavioral control variables that are perceived positively, but in memorization a negative relationship to the intention to adopt Islamic banking services.
Faktor-Faktor Penentu Nilai Perusahaan Pada Bank Umum Syariah di Indonesia Periode 2016-2020
Authors: Anggreini Gita Melliyani , Oktaviana Ulfi Kartika
Published: November 2022

This study aims to confirm whether internal factors are correlated to the firm value of Islamic commercial banks (BUS) in Indonesia, both partially and simultaneously. The Economic Value Added (EVA) method was adapted to measure firm value in the 2016-2020 period. The sample studied amounted to 11 BUS. The results of the study partially show that Operational Costs on Operating Income, Company Size, and Company Growth have a significant effect on the company value of Islamic commercial banks in Indonesia. On the other hand, Capital Adequacy Ratio, Non Performing Financing, Debt to Equity Ratio, Return on Assets, Operating Costs to Operating Income, Company Size, Company Growth and Institutional Ownership simultaneously affect the value of Islamic commercial banks in Indonesia. The variables of Capital Adequacy Ratio, Non Performing Financing, Debt to Equity Ratio, Return on Assets, Operational Costs to Operating Income, Company Size, Company Growth and Institutional Ownership are able to explain the influence of 46.9% on the value of Islamic commercial banks. While the remaining 53.1% is explained by the independent variables that are not examined.