bluuebunny/crossref_metadata_2025 huggingface dataset:
MERDEKA BELAJAR (PESANTREN DAN KEMADIRIAN SANTRI AL-AMIEN PRENDUAN)
Authors: Alfian Abdul
Published: January 2022

Penelitian ini dilatarbelakangi dengan kenyataan bahwa Sejak awal, pondok pesantren telah menanamkan sikap kemandirian pada diri peserta didik, dengan cara melatih mereka agar dapat berdiri di atas kaki sendiri, serta membina mereka agar tidak menggantungkan diri kepada orang lain kecuali hanya kepada Tuhan.  Begitupun dalam hal belajar para santri dididik dan dibentuk dengan sistem dan program yang ada di dalam pondok tersebut agar mereka dapat menyelesaikan sendiri masalah-masalah belajar yang mereka temui. Akan tetapi setiap Pondok Pasti memiliki cara-cara tersendiri dalam usahanya menciptakan sikap kemandirian belajar dalam diri santri.Tujuan penelitian ini adalah; 1. Untuk mengetahui bagaimana peran Pondok Pesantren Al-Amien Prenduan dalam menciptakan kemandirian belajar santri, 2. Untuk mengetahui program apa saja yang dimiliki Pondok Pesantren Al-Amien Prenduan yang dapat menunjang terciptanya kemandirian belajar santri. Penelitian ini menggunakan pendekatan kualitatif lapangan (field research), dengan teknik pengumpulan data berupa observasi, wawancara kepada narasumber yang dianggap penting dan dokumentasi. Kemudian untuk menganalisis data peneliti menggunakan teknik reduksi data, penyajian data dan kesimpulan atau verifikasi. Untuk menetapkan keabsahan data peneliti menggunakan teknik triangulasi sumber dan triangulasi teknik. Adapun hasil dari penelitian ini adalah Seluruh komponen dan sistem yang ada di dalam pondok pesantren  Al-Amien Prenduan berperan penting dalam menciptakan kemandirian belajar dalam diri santri.  Misalkan dari SDM-nya, seperti para guru, kepala sekolah, pengasuh dan  pimpinan pondok  pesantren. Keberadaan mereka sangatlah dibutuhkan oleh para santri, sebagai motivator, pembimbing sekaligus orang tua kedua mereka di pondok.  Kemudian penciptaan kemandirian belajar juga tercipta dari program-program yang telah dibentuk oleh   pondok, seperti kelompok-kelompok  keilmuan dan kebahasaan dan lain-lain.  Adapun program pondok pesantren Al-Amien Prenduan yang mendukung terciptanya kemandirian belajar santri yaitu program muajjah, program kelompok, program penuntasan SKIA dan program  remidial. Kata Kunci : peran pesantren, kemandirian belajar
Bimbingan Nilai-Nilai Spiritual Di Madrasah Aliyah Mafaza Bantul Yogyakarta
Authors: Wahyudi Heri Fadli
Published: January 2022

The cultivation of spiritual values to learners is a very vital step in shaping the characteristics and character of the human person, because the internalization of spiritual values is closely related to the cultivation of religious values, and is part of the formation of adolescent character as the next generation of religion and nation. This research is to find out the process of planting and internalizing spiritual value education conducted at The Senior high school of Mafaza Institute located in the Maguntapan Bantul area of Yogyakarta, while the type in this study is qualitative with a descriptive approach, while the subject in this study is teachers or teachers at this institution as well as some M.A. Mafaza students. While the data collected passes through the process of interviews, observations and documentation which then the author of the data analysis to draw conclusions. The results of this study show the following: 1). The process of planting and internalizing values and spiritual in this institution is carried out with an understanding of the material in the classes. 2). Then as a follow-up in the form of application in programs and activities such as requiring mandatory congregational prayers, sunnah worship and others, there are also activities such as the loving mosque and the the Adiwiata program. So from there it is seen that all aspects in value and spiritual, namely the aspect of Aqidah and Worship become the center of attention in planting to their students. So that it covers everything, either in the pattern of vertical relationship (Servant-Godnya) or horizontal (Servants and Environment).
Taraxasterol presente en hojas de Jatropha gaumeri Greenm, como teórico antagonista parcial del receptor muscarínico Acho-M;, del tracto gastrointestinal
Authors: D Cu-Quiñones Luis , Chan-Bacab Manuel J , Granados-Echagoyen Carlos , Ortega Morales Benjamin O. , Zamora-Crescencio Pedro , Hernández-Núñez Emanuel , Gomez-Galicia Diana Lizbeth , Aguirre-Crespo Francisco J.
Published: January 2022

Jatropha gaumeri es un árbol endémico de la Península de Yucatán, México, y cuenta con estudios etnomédicos,fitoquimicos y farmacológicos. En el presente trabajo se plantea generar información teórica que relacione las propiedadesfisicoquímicas y biológicas con los efectos atribuidos en la medicina tradicional y certidumbre en el desarrollo de estudiosexperimentales. J. gaumeri se analizó por gravimetria y espectroscopia (UV-Vis, FTIR) y taraxasterol (6) medianteMolinspiration, Osiris y AutoDock Vina para el acoplamiento con el receptor muscarínico tipo 3 (Acho-M3r). Se registraun rendimiento del 14.66 ± 0.75%, por UV-Vis se identifican bandas relacionadas a compuestos fenólicos y flavonoides;por FTIR se identifican bandas relacionadas con 6. Por otro lado, 6 presenta una violación a la Regla de Lipinski,interacción con receptores nucleares, enzimas y con receptores acoplados a proteinas G, no se reportan riesgos demutagenicidad, tumorogenicidad, irritabilidad y sobre reproducción. 6 presenta alta probabilidad de absorción en tractogastrointestinal (TGD, inhibición de OATP1B1, BSEP y hERG, sustrato del CYP3A4 así como de receptores aestrógenos. El sitio activo del Acho-M3r se optimizó con escopolamina (RMSD: 2.48 Á) y 6 registro una alta afinidad conel Acho-M3r, pero menor a la de escopolamina (-10.18 vs.-5.9 Kcal/mol); los valores de Ki (0.03 vs. 0.48 uM) presentanel mismo comportamiento, hechos que sugieren interacción parcial mediante fuerzas de Van der Waals. Bajo estecontexto, 6 presenta buena absorción, baja permeabilidad, potencial acumulación en la superficie apical del enterocito,interacción con los Acho-M3r favoreciendo la inducción de efectos a nivel del TGI, modificación de la biodisponibilidady la farmacocinética de fármacos empleados de manera simultánea con las preparaciones tradicionales de J. gaumeri,entre otras especies vegetales medicinales. Se requieres evaluaciones experimentales (in vitro, ex vivo, in vivo) quecorroboren el planteamiento.
CHARACTERIZATION OF PREDICTED BACTERIAL COLD-ADAPTED LIPASE FROM SEAFOOD COLD STORAGE
Authors: Yufidasari Hefti Salis , Astuti Retno Tri , Waluyo Eko , Malau Jekmal
Published: January 2022

Lipases constitute as top three most important group of enzymes along with  carbohydrases and proteases, and are widely used in various industries. In particular, lipase that perform high activity at low temperatures, or referred as cold adapted lipase (CLPs) considered as attractive catalyst due to its activity at low temperature. This unique feature is the main advantage of cold adapted lipase utilization because it requires a low energy source that is correlated with lower production costs and energy. In addition, reactions occur in cold temperatures may result in better product quality. The purpose of this research was to perform screening and characterization of bacterial cold adapted lipase from seafood cold storage. Among 53 isolates, Kr_16_30, TI_37_14 and Kr_16_28 showed the highest activity with 4.12 U/mL; 3.87 U/mL and 3.21 U/mL, respectively. Isolates Kr_16_30 seemed to be typical cold adapted lipase with optimum temperature at 20°C and pH 7. Isolates Kr_16_28 performed highest lipolytic activity at 30°C while TI_37_14 suspected to be similar to typical mesophilic lipase with optimum temperature at 40°C. Species identification based on 16s rRDA sequencing revealed that isolates Kr_16 30 and Kr_16 28 are belong to genus Pseudomonas and Bacillus, repectively.
RELATIONSHIP OF LEADER SUPPORT WITH EMPLOYEE WORK ACHIEVEMENT AT SEI SUKA DISTRICT PUSKESMAS SEI SUKA BATU BARA DISTRICT 2019
Authors: Muharraran Firdha , Purba Ivan Elisabeth , Nababan Donal
Published: January 2022

Background: The national health system is essentially an order that reflects the efforts of the Indonesian people to increase their ability to achieve health status. Puskesmas is a leading health service organization unit that provides comprehensive and integrated health services to the community. Human resource management is a planning, organizing, coordinating, implementing, and supervising the procurement, development, provision of remuneration, integration, maintenance, and separation of workers in order to achieve organizational goals. One way to improve resource management is leadership support for outstanding employees.

Purpose: This study aims to determine the relationship between leadership support and employee performance at the Sei Suka Health Center, Sei Suka District, Batu Bara Regency in 2019.

Method: This research was conducted cross sectional with data collection method (questionnaire). Each group with an age range of 20-30 years, 31-40, 41-50, 51-60 was given a questionnaire to fill out. Determination of the relationship between leadership support and employee performance can be seen from the results obtained after filling out the questionnaire, then the data is analyzed using the chi-square test.

Results: The results obtained that the most respondents in the category of good leadership support as many as 16 people (48.5%) had poor work performance and the least was good leadership support 2 people (6.1%) had good work performance after being tested with the chi test square can be seen that the value of Significancy p value = 0.003 (P <0.005) which shows that the relationship between leadership support and employee performance is significant.

Conclusion: there is a significant relationship between leadership support and employee performance.
Estratégias de Enfrentamento da Evasão Escolar via Tecnologias Digitais:
Authors: Souza Fábio Kalil de , Dos Santos Guimarães Wagner , Teixeira Guedes Josevânia , José Barreto Alves Maria
Published: January 2022

Sabe-se que o desenvolvimento de uma nação e a inserção e ascensão social do indivíduo passam pela educação, tanto informal quanto formal, sistemática. Nesta, a escola representa o lócus central de formação na Educação Básica, e a permanência do estudante se configura condição para êxito e continuidade dos estudos em fases posteriores. Do contrário, abandonar ou evadir-se desse espaço pode gerar danos para a sociedade e ao próprio sujeito. No Brasil a evasão escolar acontece em diferentes níveis e modalidades de ensino e se constitui um dos principais problemas sistêmicos enfrentados por governantes e gestores educacionais nas últimas décadas. Não obstante tal fenômeno, aprofundado pela pandemia Covid-19, provoque prejuízos humanos e socioeconômicos, tem sido vigorosamente combatida por ações institucionais e políticas públicas, embora resultados nem sempre louváveis estejam sendo alcançados.  Este trabalho trata de busca de soluções via tecnologias para dirimir a evasão no Ensino Médio no duro período do novo coronavírus. Tem como objetivo geral tão somente descrever as estratégias de enfrentamento da evasão escolar no ensino técnico de nível médio desenvolvidas pela equipe multiprofissional do IFS-Campus Lagarto com utilização de instagram, ligações telefônicas, aplicativo de bate-papo online e de vídeo-chamadas. Como método optou-se por uma abordagem qualitativa de cunho descritivo. O estudo conclui a viabilidade e eficácia de acompanhamento psicossocial e pedagógico por meio dessas tecnologias e aponta limites e possibilidades de novas pesquisas.
KENDALA DAN SOLUSI PENGISIAN DAN PELAPORAN E-FILING PPH PASAL 21 ATAS GAJI KARYAWAN DI KANTOR PELAYANAN PAJAK PRATAMA MATARAM BARAT
Authors: Ningsih Faradilla Iqriani , Emi Salmah
Published: January 2022

Tujuan dari penelitian yaitu untuk mengetahui “Kendala Dan SolusiPengisian Dan Pelaporan E-FilingPPh Pasal 21 Atas Gaji KaryawanDi Kantor Pelayanan Pajak Pratama Mataram Barat. Tujuan dari pelaksanaan PKL adalah Untuk mengetahui mekanisme pengisian dan pelaporan E-Filing PPh pasal 21 atas gaji karyawan di Kantor Pelayanan Pajak Pratama Mataram Barat, Untuk mengetahui kendala dan solusi pengisian dan pelaporan E-Filing PPh Pasal 21 atas gaji karyawan di Kantor Pelayanan Pajak Pratama Mataram Barat.

Berdasarkan hasil dan pembahasan yang diperoleh selama penelitian pada Kantor Pelayanan Pajak Pratama yaitu mekanisme pelaporan dan pengisian E-Filing dilakukan melalui tiga tahap utama yaitu mengajukan permohonan E-FIN mendaftarkan diri sebagai Wajib Pajak E-Filing, dan menyampaikan SPT Tahunan secara E-Filing untuk Wajib Pajak Orang Pribadi. Dalam tiga tahap mengajukan permohonan E-Filingtersebut, Wajib Pajak harus terlebih dahulu mengurus pengajuan E-Fin dengan tahapan-tahapan yang ditentukan seperti menyediakan berkas-berkas atau syarat pengajuan E-Fin, yaitu kartu NPWP Wajib Pajak yang terdaftar, KTP yang terdaftar, dan formulir yang wajib di isi yang disediakan orang kantor pajak tersebut.Kemudian perbandingan mekanisme pengisian SPT Tahunan Wajib Pajak dengan sistem E-Filing yang terdaftar di KPP Pratama Mataram Barat dengan ketentuan Perpajakan yang berlaku, berdasarkan teori dengan Praktek Kerja Lapangan di KPP Pratama Mataram Barat sudah sesuai dengan landasan teori Perpajakan yang berlaku, seperti langkah-langkah atau pengisian dan pelaporan SPT Tahunan Wajib Pajak Orang Pribadi dengan formulir SPT 1770S maupun 1770SS. Sedangkan kendala-kendala yang dihadapi dalam pengisianE-Filing antara lain wajib pajak belum melakukan registari akun DJP,kurangnya pengetahuan Wajib Pajak , server down , kesalahan pribadi Wajib Pajak seperti lupa email , lupa password , belum memiliki E-FIN, tidak memiliki email , tidak membawa bukti potong, dan malas melapor.

Simpulan dan saran epada petugas Kantor Pelayanan Pajak Pratama Mataram Barat untuk terus meningkatkan sosialisasi kepada masyarakat tentang penyampaian laporan SPT Tahunan secara E-Filingagar banyak Wajib Pajak yang mengetahuidan memahami mekanisme pengisian E-Filing, serta memperbanyak pojok-pojok Pajak yang tersebar di berbagai desa dan memberitahukan jauh hari sebelum pelaporan SPT Tahunan dimulai.
POTENSI PENERIMAAN RETRIBUSI CUKAI PASAR DAN SEWA RUANG PADA BAPENDA DI UPT. WILAYAH 1 GERUNG KABUPATEN LOMBOK BARAT
Authors: Alfiani Baiq Novi Alfiani , Baiq Ismiwati
Published: January 2022

Penelitian dengan Judul: “Potensi Penerimaan Retribusi Cukai Pasar dan Sewa Ruang Pada Bapenda Di UPT. Wilayah 1 Gerung Kabupaten Lombok Barat”. Bertujuan untuk mengetahui potensi penerimaan retribusi pasar terhadap pendapatan asli daerah kabupaten Lombok Barat dan mekanisme perhitungan retribusi pasar di pasar gerung, tujuan penelitian ini adalah mengukur jumlah potensi penerimaan retribusi pasar di Kabupaten Lombok Barat, yang mana hasil potensi akan dijadikan acuan sebagai dasar mengukur efektivitas penerimaan retribusi pasar, agar penilaian hasil kinerja dari pemungutan retribusi pasar lebih raelistis.

Setiap pasar dikepalai oleh seorang kepala pasar yang bertugas untuk mengurus, mengelola dan membina setiap pedagang dalam pasar. Retribusi dipungut setiap hari oleh petugas pemungut retribusi dan selanjutnya disetorkan ke Pembantu Bendaharawan Khusus untuk dihitung ulang, lalu dikirim ke Bendaharawan Khusus Penerima dan kemudian disetorkan ke Bank. Retribusi dibayar sesuai kesepakatan pedagang ada yang setiap hari, perminggu, perbulan dan pertahun, saat terutang apabila lebih dari waktu yang telah ditentukan tidak dibayar, ditagih dengan surat teguran.

Maka potensi retribusi pasar adalah jumlah seluruh orang yang berdasarkan peraturan perundang-undangan yang berlaku wajib membayar retribusi pasar karena memanfaatkan fasilitas yang disediakan pemerintah daerah.
Genetic Analysis and Seed Polymorphism in Inter sub Specific Cross of Blackgram (Vigna mungo (L.) Hepper)
Authors:   Department of Pulses, Centre for Plant Breeding and Genetics, Tamil Nadu Agricultural University, Coimbatore-641003, S Manju Devi , P Jayamani ,   Department of Pulses, Centre for Plant Breeding and Genetics, Tamil Nadu Agricultural University, Coimbatore-641003, M Kumar ,   Tamil Nadu Agricultural University, Coimbatore-641003
Published: January 2022

The present study was carried out using 189 pre-breeding lines from the cross VBN (Bg) 5 and Vigna mungo var silvestris 22/10 to study the genetic variability for nine yields and six seed traits. Significant variability was observed for all the traits studied. The phenotypic coefficient of variation (PCV) was higher than the genotypic coefficient of variation (GCV) for all the 15 traits. High PCV was observed for number of pods per plant, seed volume, and single plant yield. The moderate to high GCV was exhibited for hundred seed weight, plant height, number of pods per plant, seed volume, and single plant yield. The heritability estimates were high for pod length, plant height, seed length, hundred seed weight, single plant yield, bulk density, seed length-width ratio and seed width. The traits viz., plant height, hundred seed weight, and single plant yield showed high heritability along with high genetic advance as per cent of mean respectively, which might be due to additive gene action. Hence, these traits could act as a better source for the breeding programme for evolving high-yielding bold seeded varieties.
Review of Coronavirus disease- 2019 (COVID-19) in Iraq
Authors: Huda Sahib Abdul Mohammed Al-Rawazq
Published: January 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) or 2019 novel coronavirus (2019-nCoV) is quickly spreading to the rest of the world, from its origin in Wuhan, Hubei Province, China. And becoming a global pandemic that affects the world's most powerful countries. The goal of this review is to assist scientists, researchers, and others in responding to the current Coronavirus disease (covid-19) is a worldwide public health contingency state. This review discusses current evidence based on recently published studies which is related to the origin of the virus, epidemiology, transmission, diagnosis, treatment, and all studies in Iraq for the effect of covid-19 diseases, as well as provide a reference for future researchers. The findings of this review show significant differences across gender, age group, area of residence, environmental agents (temperature, humidity), and people with chronic diseases (hypertension, diabetes mellitus, heart disease, respiratory disorders, and immunocompromised disease). To control the pandemic, information about COVID-19 was disseminated to people, including wearing a face mask and using a social distancing strategy as an effective tool for controlling COVID-19. More education and progress are required to convince the public that the vaccine is both effective and safe.
Microbiological dynamics involved in cereal-porridge production using maize and sorghum
Authors: Mercy M Umokaso  , Bernard JO Efiuvwevwere  , Francis S Ire
Published: January 2022

Cereal-porridge(‘ogi’) was produced by spontaneous fermentation using maize and sorghum substrates. The microbiological dynamics involved were monitored over a period of 48h fermentation. Bacteria, yeasts and moulds were isolated. Based on the morphological, cultural and biochemical test results, the aerobic bacterial isolates were identified as Proteus vulgaris, Proteus mirabilis, Klebsiella sp, Staphylococcus aureus, Lactobacillus sp, Pseudomonas sp, Citrobacter sp, Bacillus sp, Proteus sp, Shigella sp, and Escherichia coli. The Lactic acid bacteria were Lactococcus sp, Enterococcus sp, Lactobacillus fermentum, Lactobacillus sp. The yeast isolates were 2 strains of Saccharomyces cerevisiae, one other Saccharomyces sp and a Candida sp. The moulds were Aspergillus niger, Aspergillus flavus, Rhizopus sp and Penicillium sp. The lactic acid bacteria (LAB) isolated were 2 strains of Lactococcus lactis, 2 Enterobacter spp, 5 strains of Lactobacillus fermentum and 1 other Lactobacillus sp. The initial total viable aerobic bacterial count at 0h in maize, sorghum and maize-sorghum blend were 4.6 × 104, 7.3 × 104 and 2.4 × 105cfu/ml respectively. The growths rose to peaks of 6.5 × 107 and 3.9 × 107cfu/ml at 24h in maize and maize-sorghum blend, respectively. A Peak of 4.7 x 107cfu/ml was attained at 36h in sorghum. Coliform bacteria and moulds growths in the three samples attained peaks of growth at 12h and reduced till there was no growth by 48h. Lactic acid bacteria and yeasts increased in numbers till the end of fermentation. The initial pH value at 0h was lowest in maize-sorghum blend sample (5.43) and highest in maize (5.75). Final values at 48h were 3.76, 3.78 and 3.75 in maize, sorghum and maize-sorghum blend samples respectively. There were no significant differences between the microbial growth patterns, changes in pH, total titratable acidity (TTA) and amylase enzymatic activities in maize, sorghum and maize-sorghum blend samples during fermentation.
Analysis of land use change in Mangrove of the Barra San José, Chiapas, Mexico
Authors: Karla Mildred Cigarroa-Alonso  , Gladys Linares-Fleites  , Miguel Ángel Valera-Pérez
Published: January 2022

Mangroves are the most productive ecosystems in the world, since they provide ecosystem services, are biological filters, stabilize the coastline and are the habitat of important fishing species and migratory birds nest. However, the inadequate implementation of agricultural, livestock and tourism development policies has implied the loss of biodiversity, habitat fragmentation and deforestation. The objective of this work is to evaluate the dynamics of changes in mangrove cover and land use in Barra San José, Chiapas, Mexico, in the period 1978-2017. The detection of the changes was carried out by means of a post-classificatory multitemporal study, through the superposition of digital cartographic bases of land use of the series III and VI of the INEGI. Maps of change processes, deforestation rates, and change matrices were obtained. The results indicate a loss of 574 ha of Mangroves in 39 years, with a deforestation rate of -0.41%, where human settlements and agriculture accounted for 90% of the changes. The conversion of Mangroves to grasslands was very marked, showing the fragmentation and loss of habitat to which the forests are exposed in the study area. The results of this analysis should be considered in the establishment of management and conservation policies for this ecological region.
Epidemiological, clinical and evolutionary aspects of hypotrophic newborns at term at the Mother and Child University Hospital of N'Djamena
Authors: Silé Souam Nguélé  , Adrienne Ngaringuem  , Kounnezouné Patalet  , Kanezouné Gongnet  , Djaury Dadji-a  , Hikdjolbo Gonzabo  , Folquet Amorissani
Published: January 2022

Introduction: Hypotrophy is a public health problem in developing countries. Its etiology is multifactorial and it may be associated with high morbidity and mortality. The objective of this study was to describe the epidemiological, clinical and evolutionary profile of hypotrophic newborns at term. Methodology: this was a prospective, descriptive and analytical study conducted in the neonatology department of the MCUH of N'Djamena from 01/06/2018 to 31/05/2019. It involved 109 hypotrophic newborns at term hospitalized. Results: The frequency of hypotrophy was 7.8%, the risk factors were: housewife status (81.7%), low level of education (67%), poor pregnancy follow-up (59.7%), malaria (40.4%), urogenital infections (22%) and anemia (22%) during pregnancy. Hypotrophy was harmonious in 58.7% of cases, the sex ratio was 1.14 and visible congenital malformations were observed in 12.7% of cases. The main reasons for hospitalization were neonatal infections (64.2%), perinatal asphyxia (14.7%) and hypothermia (11.9%). Lethality was 16.5% and associated with multiparity, poor pregnancy follow-up, vaginal delivery, home delivery, pathological Apgar score, notion of resuscitation, existence of malformation, respiratory distress and perinatal asphyxia. Conclusion: Better monitoring of pregnancy, use of family planning by couples, delivery in an institutionalized setting, and reinforcement of the technical platform of the neonatology department will reduce neonatal morbidity and mortality related to hypotrophy.
Webinar’s effect on nutritional knowledge to enhance immunity during COVID-19 pandemic
Authors: Intan Permata Sari  , Fauziah Adhima  , Ghivari Zuhal Fahmi  , Ramidha Syaharani  , Widati Fatmaningrum
Published: January 2022

Introduction: As of 31st December 2021, there have been 4,262,540 confirmed cases of COVID-19, including 144,088 death cases in Indonesia. COVID-19 pandemic has affected the nutrition aspect, as an increasing number of undernutrition children also increases risk of obesity. Our group conducts webinars with the purpose of increasing public knowledge and awareness regarding general well-being: importance of adequate nutrition to increase immunity in the COVID-19 pandemic. The purpose of the study is to examine webinar participants' knowledge before and after webinar. Method: The webinar conducted through a zoom meeting for 2 hours consists of 1 hour education and 1 hour question and answer session. The participants asked to fill a pretest before the webinar session and posttest after the webinar session. The results were statistically examined to determine the difference between pretest and posttest score. Results: The webinar participant’s demographic characteristics were dominated by 17-45 years old age group, high school graduates, and female participants. There is a significant difference (p<0.05) between pre and post-test score evaluated using Wilcoxon signed-rank test. After the webinar, there is a decreased number of participants with low-level nutritional knowledge from 31 to 23 participants. Conclusion: There is an increase in knowledge about the importance of adequate nutrition to increase immunity in the COVID-19 pandemic from pre and post-test data. Thus, this webinar contributes to providing knowledge to participants in supporting the strengthening of socialization of adequate nutrition during COVID-19 pandemic.
Analisis of budget costs with different treatment efficiencies of newly diagnosed tuberculosis patients with multiple drug resistant pathogen
Authors: Kuznetsov N.V. , Lesonen A.S. , Markelov U.M. , Mikhailova E.D.
Published: January 2022

The article presents the results of predicting the dynamics of the spread of new cases of tuberculosis (TB) with multiple drug resistance (MDR) in the Republic of Karelia, as well as the costs of treating patients with tuberculosis, considering the different effectiveness of treatment. It has been demonstrated that while enhancing efficiency of treatment, due to the rapid determination of drug resistance by the method of polymerase chain reaction and a decrease in treatment gaps (using food kits), the effectiveness of treatment is significantly increased and the prevalence of MDR-TB decreases, which leads to significant budget savings.
Validation of the pharmacoeconomic model of cost-effectiveness analysis of insulin degludec (Tresiba®) in comparison with the insulin glargine u300 in the treatment of type 2 diabetes mellitus in the Russian Federation
Authors: Globin M.V. , Kulikov A.Y. , Litvinova A.A. , Serpik V.G.
Published: January 2022

The global pharmacoeconomic model of cost-effectiveness analysis of insulin degludec (Tresiba®) use in comparison with insulin glargine U300 in the treatment of type 2 diabetes mellitus, was validated. As the result, it was found that the model is relevant to local clinical practice, fully complies with the pharmacoeconomics methodology, takes into account the entire spectrum of costs relevant for the pharmacoeconomic evaluation of insulin in Russia, and the computations built in it is correct. Based on the actual cost data entered, the model calculated the ICER of degludec insulin, which was 214,714 rubles, which does not exceed the sum of three GDP per capita – 2,184,562 rubles and corresponds to the willingness to pay threshold in the Russian Federation. Thus, the insulin degludec (Tresiba®) can be considered as cost-effective from the standpoint of the conducted pharmacoeconomic analysis.
ANALYSIS OF COMPLIANCE WITH THE REQUIREMENTS OF GOOD PHARMACY PRACTICE FOR PHARMACEUTICAL CONSULTINGWHEN CHOOSING OTC DRUGS ON THE WEBSITES OF ONLINE PHARMACIES
Authors: Lukoianova I.E. , Egorova S.N.
Published: January 2022

Purpose of the study: to analyze the current state of Internet pharmacy websites in terms of compliance with Good Pharmacy Prac- tice requirements for pharmaceutical counseling for OTC-medicines. Methods. The study used the method of content analysis; a search was carried out in the search engines Google and Yandex for the keywords, «buy a pharmacy», «a drug store to buy a drug», «online pharmacy». TOP 25 pharma- cy websites were subjected to logical, comparative and structural analysis. The study consisted of 2 stages: an anal- ysis of the requirements of regulatory documents for pharmaceutical consulting when selling OTC drugs and an as- sessment of pharmacy websites in terms of ensuring compliance with these requirements when carrying out online commerce. Results. Studies of online pharmacy websites showed that most of the sites did not fully comply with the regulated require- ments: a pharmaceutical license is presented on 80% of sites, information on the type of pharmacy organization, on the impossibility of returning and exchanging pharmacy goods - on 76% of sites. The choice of OTC drugs based on symptoms within the framework of responsible self-medication was available on 24% of Internet pharmacy sites, but there were no indications of symptoms requiring immediate medical attention. Links to the State Register of Maximum Selling Prices were available on 8% of Internet pharmacy sites. Conclusion. Comparative analysis of information requirements in relation to pharmaceutical consulting in a pharmacy, reg- ulated by Orders of the Ministry of Health of Russia No. 80 «On approval of the Industry standard» Rules for the dispensing (sale) of medicines in pharmacies. Basic provisions «and No. 647n dated 31.08.2016» On approval of the Rules Good Pharma- cy Practice of Medicinal Products for Medical Use ”, Government Decree No. 697 of May 16, 2020“ On Approval of the Rules for Issuing Permits for Remote Retail Sale of Medicinal Products for Medical Use, Implementation of Such Trade ... ”, showed that most of the requirements for offline pharmacy were reflected in relation to Internet pharmacies, however, as a result of the analysis of Internet pharmacy websites, it was found that these requirements are not fully met. Additional criteria for evaluating online pharmacy sites corresponding to the level of pharmaceutical care in an offline pharmacy are proposed: the ability to select an OTC drug by symptoms within the framework of responsible self-medication, the presence of indications of symptoms that require immediate medical attention, the presence of instructions for the medical use of the drug in in ac- cordance with the State Register of Medicines, ensuring access to the State Register of maximum selling prices, availability of information on the actual shelf life of the medicinal products being sold.
PHARMACY CONSULTING: NEW DRUG FORMS AND NEW OPPORTUNITIES
Authors: Arinina E.E.
Published: January 2022

Pain syndrome of various origins and varying intensity is the most common and leading reason for seeking medical care in the world. The main drugs for the relief of both acute and chronic pain syndrome from the 20th century to the present are non- steroidal anti-inflammatory drugs (NSAIDs). More than 30 million people worldwide receive them every day. Along with pain, other common indications for NSAIDs are fever and inflammation. All NSAIDs differ in the degree of effectiveness, form of release, speed of onset of clinical effect and dosage. That is why one of the fundamental tasks of the pharmacist, in the framework of pharmacy counseling, is to provide the patient with quality medicines and teach them how to use them rationally. With the rapid development of medical and information technologies in the modern world, the fulfillment of this task becomes more and more important, complex and responsible action. The appearance, on the pharmaceutical market innovative NSAIDs in accelerated-release dosage’s forms (for example, Ketorol® Express), makes it possible to expand the pharmacy list.
CHARACTERISTICS OF SHACKLE GRAPH: Shack(Kn,v(j,i),t), Shack(Sn,v(j,i),t), & Shack(K(n,n),v(rj,i),t)
Authors: Firmansyah Firmansyah , Mujib Abdul
Published: January 2022

Abstrak:

Operasi schackle adalah operasi antara dua atau lebih graf yang menghasilkan graf baru. Graf shackle dinotasikan  adalah graf yang dihasilkan dari t salinan dari graf  yang diberi simbol dengan  dimana  dan t bilangan asli. Operasi shackle ppada penelitian ini adalah shackle titik. Operasi shackle titik dinotasikan dengan  artinya graf yang dibangun dari sembarang graf  sebanyak  salinan dan titik  sebagai . Kelas graf yang akan di eksporasi karakterisinya dan bilangan kromatinya adalah , S , & S . Hasil penelitiannya menunjukkan bahwa bilangan kromatik graf shackle sama dengan subgraf pembangunnya.

 

Kata Kunci:

Operasi Shackle, Shackle titik, graf shackle, bilangan kromatik.

 

Abstract:

A shackle operation is an operation between two or more graphs that results in a new graph. Shackle graph notated   is a product graph from   copy of graph   is denoted by   where   and   are natural numbers. The shackle operation in this research is vertex shackle. Vertex shackle operation is denoted by   which means that the graph is constructed from any graph   as many as   copies and vertex   as linkage vertex. The class of graphs examined in this study are  , S , & S . The results show that the chromatic number of the shackle graph is the same as the subgraph that generates it.

 

Keywords:

Shackle Operation, Vertex Shackle, Shackle Graph, Chromatic Numbers.
Campo de Montiel y Sierra de Alcaraz: ríos de cabecera de cuatro cuencas hidrográficas ibéricas
Authors: Pozo Martínez Jesús
Published: January 2022

En un pequeño territorio de las comarcas del Campo de Montiel y de la Sierra de Alcaraz (sur de Castilla-La Mancha, España) se inician las redes de drenaje de 4 de las principales cuencas hidrográficas de la Península Ibérica: Guadalquivir, Guadiana, Júcar y Segura. Este trabajo pretende examinar la variabilidad físico-química de los ríos de cabecera de estas cuencas. Visores geográficos, medidas de campo y análisis de aguas en laboratorio han proporcionado los datos que indican que orografía, litología y clima condicionan el régimen hidrológico de estos ríos, muchos de ellos, intermitentes o efímeros. Escasez de agua y contaminación por nitratos derivados de la agricultura son problemas que podrían agravarse con el cambio climático, especialmente en la cabecera del Guadiana.
Mercados matrimoniales entre municipios rurales de la comarca Campo de Montiel. El caso de Ossa de Montiel (Albacete) y Villahermosa (Ciudad Real)
Authors: Muñoz Oliver Soledad
Published: January 2022

Comparto algunos resultados de mi tesis doctoral que buscan contribuir al estudio de los municipios de la comarca Campo de Montiel (histórico). Indago en el matrimonio como uno de los indicadores más potentes para explicar la realidad social, en este caso la rural. Parto del análisis del género y del parentesco, desde la antropología y utilizando el trabajo etnográfico para acercarme a los datos cualitativos. Con mi descripción pretendo, sin agotar todos los escenarios posibles, conocer mejor los mercados e intercambios matrimoniales entre hombres y mujeres y lo que ello ha supuesto. Realizo la aproximación desde el conocimiento situado a partir de un estudio de caso en torno a los matrimonios entre Ossa de Montiel (AB) y Villahermosa (CR) durante el periodo 1981-1993.
ENERGY CERTIFICATION AND ENERGY AUDIT OF HIGHER EDUCATION AS A METHODOLOGICAL TOOL TO IMPROVE THE ENERGY EFFICIENCY OF THE UNIVERSITY
Authors: Hanushchak-Yefimenko Liudmyla
Published: January 2022

BACKGROUND AND OBJECTIVES. Improving the energy performance of buildings is one of the least expensive ways to reduce energy consumption and greenhouse gas emissions. Building energy performance certification increases public knowledge about energy conservation and allows consumers and other decision makers to compare buildings based on their lifetime performance. In addition, energy performance certifications are an incentive for owners to improve the efficiency of existing buildings.METHODS. It is proposed to use in the process of energy certification and energy audit of university buildings collection and evaluation of basic information (including information about local climate, method of use, value of thermal conductivity coefficient and building envelope area, orientation) to determine the level of energy efficiency of the building on a generally accepted scale. In the Certificate of energy efficiency to take into account the calculated results from the assessment of the energy performance of the building.FINDINGS. It is suggested that the results of the energy certification of university buildings be presented in a simple, clear form, to ensure clarity, ease of use and comparability. For the energy certification of university buildings, a comparative labeling from A to G is proposed for use. The scale, on which the current national building standard is at "C," provides ample room for improving the rating of both new and existing buildings. If necessary, the scale should be expanded to add a label such as A1, A2, or A+, A++ when it comes to high-performance buildings.CONCLUSION. Accurate and reliable energy performance certification is a necessary foundation that will help ensure consumer confidence and the success of the certification program. The certification program must be clearly coordinated to ensure a smooth transition of the construction industry to the new rules.
SMART GRID ENERGY CONSERVATION MANAGEMENT BASED ON THE UNIVERSITY'S ENERGY INNOVATION HUB OF KNOWLEDGE
Authors: Volianyk Oleksii
Published: January 2022

BACKGROUND AND OBJECTIVES. Due to increasing energy costs, as well as strict environmental regulations, there is a growing need for greater resource efficiency, which makes energy-efficient solutions necessary. Thus, the importance of innovations based on technologies designed to save energy, such as the Smart Grid, is increasing. Smart Grid is not just a compilation of smart meters or other electrical devices, it is a series of technologies, a concept of a fully integrated, self-regulating and self-healing power grid, which has a network topology and includes all sources of generation, transmission and distribution, managed by a single network of information and control devices and systems.METHODS. As the main method used was the calculation of the synthetic balance of savings from the use of different types of energy resources by the university after the implementation of the application Smart Grid-energy conservation management on the basis of the university energy-innovation Hub of knowledge.FINDINGS. A mechanism for the implementation of the Smart Grid energy-saving management application on the basis of the university energy-innovation Knowledge Hub is proposed. Smart Grid is designed to provide real-time data on the almost instantaneous balance of energy supply and demand. To ensure grid reliability by reducing peak demands and improving energy efficiency, Smart Grid data management is an affordable and effective tool for data analysis and decision making.CONCLUSION. The results of calculation of the predicted effect of the Smart Grid application implementation for the 4th building of Kyiv National University of Technologies and Design proved that the reduction of installed capacity as a result of the project was 80.5%, i.e. a 1% reduction in capacity creates an economic effect of 0.58% of the costs associated with modernization. Given the current level of electricity consumption, we can predict a potential reduction of 951 thousand UAH per year or almost 50% of the cost of electricity consumed in 2020.
ADVANTAGES AND PROSPECTS OF CO-BRANDING IN THE UKRAINIAN MARKET
Authors: Dudko Pavlo
Published: January 2022

BACKGROUND AND OBJECTIVES. The marketing practices of companies over the past two decades have increasingly been based on co-marketing, or inter-firm marketing alliances. The mutual recognition and understanding that each firm's success depends in part on the other firm forms the foundation underlying co-marketing activities. Firms move from trying to win alone to forming networks of partner firms. Corporations understand the need for alliances to acquire and maintain competitive advantage.METHODS. We used general scientific and special research methods: abstract-logical – to summarize theoretical and methodological foundations of co-branding as an integrative marketing tool for joint development of companies; economic-statistical – to analyze the level of development of poultry companies; monographic – to study the experience of individual companies with horizontal form of co-branding; analysis and synthesis – to study the components of co-branding companies; sociological research – to identify key success factors of co-branding.FINDINGS. The structural and logical model of co-branding alliances of poultry companies, the use of which is based on a co-branding strategy, creates the necessary basis for its further development within the framework of modern marketing theory, will increase the effectiveness of co-branding.CONCLUSION. Co-branding, which is a form of strategic collaboration between two brands that involves bringing them together to create a new product or service, makes the marketing alliances of companies visible to the consumer. In doing so, companies imply recognition of the fact that their prominence represents added value. Closer collaboration with retailers, more focused promotion, and co-branding are becoming ways for many consumer companies to control costs and keep prices down. An example of such cooperation is the use of a co-branding strategy for poultry companies.
ІНФОРМАЦІЙНЕ ЗАБЕЗПЕЧЕННЯ ПРОЦЕСІВ ФОРМУВАННЯ СОЦІАЛЬНОЇ ВІДПОВІДАЛЬНОСТІ ЗАКЛАДІВ ВИЩОЇ ОСВІТИ
Authors: Яценко Валентина В.
Published: January 2022

The paper discusses the selected aspects related to the issues of developing social responsibility in higher education institutions. Emphasis is placed on the growing role of higher education and its evolution in modern society as a crucial element in enhancing cultural, social, economic and political development in Ukraine and as a solid foundation in building internal capacity, promoting human rights, sustainable development, democracy and justice. The study focuses on the need to adhere to the key provisions of the UNESCO Universal Declaration on Higher Education (1998), in particular, to share the idea that “higher education should be viewed as a public service. The funding of higher education requires both public and private resources. The role of the state remains essential in this regard. Public support for higher education and research remains essential to ensure a balanced achievement of educational and social missions. It is argued that the slowdown in economic growth and structural transformations have increased the value of education and its social responsibility to society. The research hypothesis is the statement that social responsibility, academic freedom and autonomy have become the driving forces in increasing the demand for higher education. In this context, it is assumed that universities should maintain a reasonable balance between these components. The purpose of the study is to substantiate the need for information support of the processes of developing social responsibility in higher education institutions within the education services market. To attain the study objectives, the following research methods were employed: expert analysis of the higher education transparency; methods of assessing the key stakeholders’ involvement (students, employers and civil society) in encouraging the University social activities. The findings have identified the challenges and barriers to fostering further academic freedom and institutional autonomy, academic freedom and public-private partnership, boosting academic freedom as an ethical dimension and social responsibility, promoting academic freedom and entrepreneurship. It is argued that education – technological progress complementarity has a number of important implications for the national economic policy. The conclusions verify that the relationships between education, innovation and qualifications is the background for developing social responsibility in universities that contributes to integrating basic education and employment, lifelong learning and maintenance of professional qualifications, promoting innovation and social accountability.
ДІДЖИТАЛІЗАЦІЯ ПІДПРИЄМНИЦТВА НА ТРАНСПОРТІ В УМОВАХ ПАНДЕМІЇ COVID-19
Authors: Scherbak Valeriia G. , Domashenko Dariia R.
Published: January 2022

The article seeks to explore opportunities for further entrepreneurship development and its intensification in a pandemic setting, in the transport sector in particular, which is associated with the constant search for and implementation of new ideas, technologies, goods, services, manufacturing methods, etc. to retain a business. An emphasis is put that in modern realia as never before, the effective functioning of any company demands for continuous improvement, renewal, reorganization, finding new pathways to manage and run a successful business. It is noted that this approach is based on the latest concept that assumes significant changes in entrepreneurship in the transport industry and will foster further business development. In addition, the study reveals that the application of digital platforms is viewed as the newest tool that has the potential to boost the transport industry growth. However, despite objective reasons, there is still a lack of proper justification for the need to use digital technologies in transport. It is noted that the Industry Development Strategy 4.0 designed by the Ukrainian Association of Industrialists and Entrepreneurs interprets digital transformation as social or technological changes associated with the penetration of digital technology into all areas of human interactions. The essence of these transformations is to find new approaches and management concepts to resolve classic business challenges. The purpose of this article is to verify the feasibility of transport entrepreneurship based on digital platforms. The study provides insights into the benefits and specifics of digitalization in the context of Covid restrictions adjusted the needs of business acceleration. To attain the research objectives, the tools of information and marketing communications were used as well as the outcomes of marketing research to summarize information on the development of courier delivery and taxi services in Ukraine. Based on the analysis of entrepreneurship in the transport industry, the essential characteristics of digital platforms for taxi service have been discussed. It is argued that a customer focus makes the basis of any successful digital strategy. However, according to the study findings, transport companies need a single comprehensive perception of their customers to develop cooperation and offer a personalized approach to them. The summary concludes that digitalization is aimed at retaining the contact between the consumer and the producer to balance twofold interests: on the one hand, to the producer it will result in profit growth, and on the other – the consumer will be able to get the enhanced service quality, thus managing a close relationship between these two market actors, even in the quarantine realia.