bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of pregnancy rates in infertile women after application of ovulation induction and intrauterine insemination
Authors: ÖKTEN Sabri Berkem , DOLGUN Zehra Nihal , UGUREL Vedat , ELTER Koray
Published: May 2020

Purpose: The aim of this studywas to investigate the effects of these factors on pregnancy rates in infertile patients following ovulation induction and intrauterine insemination. Materials and Methods: The study was performed retrospectively that investigated examination reports and laboratory results of 201 infertile patients with unexplained infertility, male factor and anovulation. Women were subdivided into two groups according to the ovary-stimulating agent used as gonadotropin or clomiphene citrate. A semen sample was obtained from all men participants. Results: There were 239 cycles of unexplained infertility (77.9%), 39 cycles in ovulatory dysfunction (12.7%) and 29 cycles in male factor (9.4%) groups. The clinical pregnancy rates per cycle according to infertility type were found as 18.4% (n:44) for unexplained infertility, 17.9% (n:7) for ovulatory dysfunction and 13.8% (n:4) for malefactor. In regression analyses, follicle (diameter>10mm) count on the day of hCG administration and inseminated total motile sperm count (ITMSC) were independently affected pregnancy rate. ITMSC area value under the curve (0.63) was significantly different from 0.5. Conclusion: Follicle count on the day of hCG administration and ITMSC independently affect the pregnancy rate. Additionally, the intrauterine insemination method should be attempted in appropriate cases that have an acceptable successful pregnancy rate.
Toplumda yaşayan yaşlılarda ağrı prevalansı ve ağrı öz yönetim uygulamaları
Authors: DEMİR SAKA Selma , GÖZÜM Prof. Dr. Sebahat
Published: May 2020

Amaç: Bu çalışma, toplumda yaşayan yaşlılarda ağrı prevalansı ve yaşlıların ağrı öz yönetim uygulamalarını değerlendirmek amacıyla yapılmıştır.Gereç ve Yöntem: Kesitsel nitelikte olan çalışmanın örneklemini, Ocak-Mart 2016 tarihleri arasında Aile Sağlığı Merkez’ine gelen, demansı olmayan 65 yaş ve üzeri 258 yaşlı birey oluşturmaktadır. Veriler; sosyo-demografik özellikler formu, Geriatrik Ağrı Ölçeği (GAÖ) ve Ağrı Öz Yönetim Uygulamaları Envanteri aracılığıyla yüz yüze görüşme yöntemiyle toplanmıştır.Bulgular: Geriatrik Ağrı Ölçeği’ne göre toplumda yaşayan yaşlılar orta düzeyde ağrı (44.7±25.6) yaşamaktadır. Yaşlıların %21.7’sinin ağrısı şiddetli, %50.4’ünün orta düzeydedir. Verilerin toplandığı gün yaşlıların ağrı algılaması hafif ağrı düzeyinde belirlenmiştir. İlaç dışı yöntemlerle ağrıyı hafifletmeye çalışan yaşlıların ağrısı hafif ağrı düzeyindedir (20.6±21.5). Ağrı kesici ilaçlarla birlikte ilaç dışı yöntemleri kullanan yaşlılar orta şiddette ağrı yaşamaktadır (51.0±22.8). Düzenli şekilde ağrı kesici kullanan yaşlıların ağrı düzeyi daha yüksektir. Yaşlıların en sık kullandıkları ilaç dışı öz yönetim uygulamaları ağrının geçmesi için dinlenme-aktivite kısıtlaması (%43.4), ağrıyan bölge üzerine herhangi bir şey sürme (%38.8), ağrıyan bölgeye masaj yapma (%33.7) ve sıcak uygulamadır (%32.6). Sonuç: Toplumda yaşayan her beş yaşlıdan biri şiddetli ağrı yaşamaktadır. Şiddetli ağrıda belirleyici olan hastalıklarda yaşlılar ağrı yönetimi konusunda desteklenmelidir.
Sağlıklı Türk yetişkinlerinde os sacrum’un ve hiatus sacralis’in klinik anatomisi ve morfometrik analizi
Authors: ÖZANDAÇ POLAT Sema , KABAKCI Ayşe Gül , ÖKSÜZLER Fatma Yasemin , ÖKSÜZLER Mahmut , YÜCEL Ahmet Hilmi
Published: May 2020

Amaç: Bu çalışma, pelvis arka duvarını oluşturan os sacrum’un anatomisini ve klinik önemini değerlendirmek ve hiatus sacralis şekillerini ortaya koymak için yapıldı. Gereç ve Yöntem: Bu retrospektif çalışmaya yaşları 18 ile 70 arasında değişen ve çeşitli nedenlerle Radyoloji bölümünde Bilgisayarlı Tomografi çektiren yüz yirmi üç (60 kadın; 63 erkek) sağlıklı Türk popülasyonu dahil edildi. Os sacrum’un maksimum uzunluğu, os sacrum’un maksimum genişliği, os sacrum genişliğinin os sacrum maksimum uzunluğuna bölünüp 100 ile çarpılmasıyla elde edilen sakral indeks değeri ölçüldü. Ayrıca, hiatus sacralis şekilleri değerlendirilerek sınıflandırma yapıldı. Bulgular: Kadınlarda sırasıyla os sacrum’un maksimum uzunluğu 106,70±12,88 mm os sacrum’un maksimum genişliği 127,67±14,72 mm, ve sakral indeks 120,11±14,64 olarak bulunurken, aynı parametreler sırasıyla erkeklerde 118,87±14,03 mm, 126,45±12,77 mm, ve 108,48±16,50 olarak ölçüldü. Ayrıca, en sık görülen hiatus sacralis şekli kadınlarda U şekilli hiatus sacralis iken erkeklerde V şekilli hiatus sacralis olarak belirlendi. Aynı zamanda, os sacrum uzunluğu ve sakral indeks değerleri ve cinsiyet arasında anlamlı farklılık bulundu. Sonuç: Os sacrum’un anatomisinin bilinmesi ve morfometrik ölçümlerinin yapılması os sacrum’u ilgilendiren patolojilerde bu bölgeye uygulanacak girişimlerde ve oluşabilecek komplikasyonların önlenmesi açısından ortopedi uzmanı, kadın doğum uzmanı, pediatrist, anestezist ve anatomistler açısından kinik öneme sahiptir.
Effect of dysmenorrhea on quality of life in university students: A case-control study
Authors: ALP YILMAZ Figen , AVCI Dilek
Published: May 2020

Purpose: This study aimed to determine the effect of dysmenorrhea on quality of life in university students and the affecting factors. Materials and Methods: This case-control study was conducted with 610 female students [300 with dysmenorrhea (case group), 310 without dysmenorrhea (control group)], who were studying at Bozok University in Yozgat, between September 2018 and December 2018. Data were collected with the Personal Information Form, Visual Analogue Scale and World Health Organisation Quality of Life Assessment-Bref. Results: In students with dysmenorrhea, physical health, psychological health, social relationships, and environmental health subscales mean scores were significantly lower than those in the control group. Furthermore, the duration of menstrual bleeding, menstruation pattern, dysmenorrhea rating, body mass index, and smoking were determined to be statistically significant factors affecting the quality of life of students with dysmenorrhea. Conclusion: Dysmenorrhea is considered to be a gynecological problem that negatively affects the quality of life. Healthcare professionals may contribute to enhancing the quality of life of students by providing training and consultation services regarding the treatment and management of dysmenorrhea.
Revisiting public health strategies for better prevention and control of noncommunicable diseases
Authors: SHRİVASTAVA Saurabh , SHRİVASTAVA Prateek
Published: May 2020

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Pregnancy outcomes of patients with rheumatoid arthritis
Authors: FADILOĞLU Erdem , UNAL Canan , TANACAN Atakan , BEKSAC M.sinan
Published: May 2020

Purpose: The aim of this studywas to evaluate the obstetric outcomes of women with rheumatoid arthritis (RA) Materials and Methods: This retrospective study consisted of 39 women with RA. Patients were evaluated in terms of seropositivity, having disease >5 years or not and use of any medication. Results: Rate of preterm delivery and intrauterine growth retardation was 33.3% and 21.2%, respectively. Comparisons between seropositive and seronegative women did not show any significant difference. Having disease more or less than 5 years did not show any significant difference in terms of obstetric outcomes. Women with a coexisting disease had a similar rate of miscarriage rate compared to remainders (16.6% vs 14.8%). Women followed up without any medication has also higher rates of miscarriage despite lack of statistical significance. Conclusion: Pregnancies of women with RA must be considered as high risk due to increased rates of adverse pregnancy outcomes such as preterm delivery and intrauterine growth retardation.
Percutaneous closure should be given a chance in patent ductus arteriosus with severe pulmonary hypertension
Authors: TEPE Ömer , ÖZMEN Çağlar , DENİZ Ali , ÖZBARLAS Nazan , TOPÇUOĞLU Mehmet
Published: May 2020

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Effect of web-assisted learning and peer learning on the stoma care-related knowledge and skills of nursing students
Authors: KAPLAN Sezgi , TÜZER Hilal
Published: May 2020

Purpose: The aim of this study was to compare the effects of web-assisted learning and peer learning on the stoma care-related knowledge and skills of nursing students.Materials and Methods: The students were divided into two groups as a web-assisted learning group (n=33) and a peer learning group (n=34) in the study. A theoretical course about stoma care was first provided to the students during the study and an initial test then administered. A video was produced for the web-assisted learning group using a low reality simulator by the investigator at the skills laboratory; this video was then loaded to the Edpuzzle software and the students asked to watch it. In the peer learning group, the peer trainers received stoma care training from the investigator and underwent practical training with the low reality simulator. These peer trainers then had the peer learning group perform the skills at the skills laboratory with a low reality simulator and evaluated the students. All the students in the two groups then performed stoma care with the low reality simulator and were evaluated by the investigator. A final test was administered to all students.Results: The mean knowledge score for the pre-test and post-test was 71.21±12.50 and 77.27±9.69, respectively, in the Web-assisted Learning Group and 67.50±10.46 and 78.24±8.52, respectively, in the Peer Learning Group. There was a significant increase in the mean knowledge test score following training in both groups.Conclusion: According to the study results, the knowledge score and skill score increased in both groups. We recommend the use of web-assisted learning and peer learning in nursing education.
Effects of hyaluronic acid and gamma-radiated mineralized allografts on the healing of rat tibial defects
Authors: GAŞ Selin , OLGAÇ Nejat Vakur , ÇEBİ Ahmet Taylan , KASABOĞLU Çetin
Published: May 2020

Purpose: This study aimed to evaluate the effects of hyaluronic acid (HyA) and gamma-radiated mineralized allografts (Gr-MAs) on the healing of bone defects in rat tibiae. Materials and Methods: Fifty-two male Sprague Dawley rats were randomly allocated to four groups: Gr-MA, HyA, Gr-MA combined with HyA (Gr-MA + HyA), and controls with empty defects. The animals were sacrificed on the 7th and 21st postoperative days. The inflammation, necrosis, fibrosis, new bone formation, and bone healing scores were evaluated on the basis of the histopathological findings. Results: The amount of new bone formation was found to be significantly greater in the control group than in the experimental groups. In addition, the healing scores were statistically higher in the control and the Gr-MA + HyA groups. Comparisons of the control, graft, and HyA groups indicated that the control group exhibited significantly less necrosis on the 7th day; however, on the 21st day, there were no statistically significant differences among the groups. There were no statistically significant differences among the groups in terms of the inflammation and fibrosis levels on the 7th or 21st days.Conclusion: Within the limitations of this study, the application of HyA alone and the addition of HyA to Gr-MA did not improve bone regeneration in rat tibial defects.
Analysis of adverse drug reactions in hospitalized patients reported to pharmacovigilance center in a teaching hospital
Authors: KHAN Zakir , ÖZ Emine , KIROĞLU Olcay , KARATAŞ Yusuf
Published: May 2020

Purpose: This study was carried out to assess the rate and pattern of adverse drug reactions (ADRs) reporting in hospitalized patients at a teaching hospital. Materials and Methods: A retrospective cross-sectional study was conducted in Balcalı Hospital at Adana, Turkey for one year. The reports were examined on the basis of demographics, ADRs type, causality, severity, seriousness, drug characteristics, and outcomes. WHO-UMC/ Naranjo algorithm scale, Hartwig and Siegel severity scale and pharmacovigilance contact point (PVCP) criteria were used to assess the causality, severity, and seriousness of ADRs respectively. Results: A total of 61105 hospitalized patients were admitted to the hospital and only 20 spontaneous ADRS were submitted to (PVCP) with an incidence rate of 0.03%. Of these, 18 eligible ADRs reporting forms were reviewed according to inclusion criteria. ADRs related to antibiotics (38.8%) were most frequently reported followed by antineoplastic agents (22.2%). Most of the ADRs were related to skin (33.3%). In causality assessment, almost 50% of the reported ADRs were possible and 55.5% were moderate in severity. Moreover, about 83.3% of the ADRs were found to be serious according to PVCP criteria. Among the total patients, 55.5% have recovered from the reactions. ADRs were reported by physicians (66.7%) followed by an assistant doctor (16.7%).Conclusion: This study shows that ADRs are a significant problem in hospitalized patients. Monitoring and management of severe and serious types of ADRs would be valuable for improved patient care.
Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey
Authors: DOGAN Ali , YILDIRIM DOĞAN Narin , ERKURT Mehmet Ali , EKİNCİ Ömer , KUKU İrfan , KAYA Emin
Published: May 2020

Purpose: This study aims to evaluate the epidemiological, demographic and clinical characteristics, and prognostic factors of the patients with non-Hodgkin lymphomas (NHL).Materials and Methods: All patients diagnosed with NHL at the Department of Hematology of Inonu University Faculty of Medicine (Turkey) between 2000 and 2016 were evaluated for this study. Only patients older than 18 years were included in the study. Characteristics were evaluated by reviewing patients’ records retrospectively.Results: Of the 386 patients studied, 242 (62.7%) were male and 144 (37.3%) were female and the overall median age was 53 years (range: 18–92). The most common histological subtype of NHL was diffuse large B-cell lymphoma (DLBCL) (46.9%). In univariate analyses, advanced stage (III-IV), high-intermediate to high risk category disease based on IPI score, bone marrow involvement at diagnosis, haemoglobin levels below 10 g/dL, increased LDH levels, primary nodal involvement, the presence of B symptoms, the exigency of autologous bone marrow transplant, and not receiving rituximab-based chemotherapy regimens as the primary treatment were all associated with shorter overall survival.Conclusion: The prevalence, clinical characteristics, histopathological subtypes, treatment responses, and overall survival rates may differ because NHL is a heterogeneous disease group and may vary according to a geographical area. Therefore, treatment should be individualized according to disease subtype.
Efficacy of dexamethasone implant in the treatment of macular edema due to different etiologies
Authors: ÖZTÜRK Emrah , ESENER Burak , GÜNDÜZ Abuzer
Published: May 2020

Purpose: The aim of this study was to evaluate the effectiveness of intravitreal DEX implant injection in the treatment of macular edema due to four different etiologies.Materials and Methods: This is a retrospective and case control study. A total of 177 patients who underwent intravitreal DEX implant between 2014 and 2018 for four different etiologies, which are diabetic retinopathy (DR), branch retinal vein occlusion (BRVO), central retinal vein occlusion (CRVO) and posterior uveitis (PU), were included in the study. Best-corrected visual acuity (BCVA) and central macular thickness (CMT) were evaluated in pre-injection, 1st, 3rd, and 6th months post-injection.Results: Eighty-one patients (45.8%) had DR, 44 (24.9%) had BRVO, 35 (19.8%) had CRVO, and 17 (9.6%) had PU. There was a statistically significant difference in BCVA in the DR, BRVO and PU groups after the injection, but no significant difference was observed in the CRVO group. It is observed that there was a statistically significant decrease in CMT in all groups after the injection. The change in CMT in the 1st month was 153.4 ± 137 µm in the DR group, 161.1 ± 151 µm in the BRVO, 270.5 ± 189 µm in the CRVO and 142.2 ± 174 µm in the PU group.Conclusion: The intravitreal DEX implant reduces the CMT in patients with macular edema secondary to various etiologies and improves BCVA in patients with macular edema secondary to various etiologies except for patients with CRVO.
Effect of titanium elastic nailing surgery on the femoral development in pediatric femoral fractures
Authors: SEVER Gökhan Bülent
Published: May 2020

Purpose: The aim of this current study was to investigate the effect of titanium elastic nailing surgery following the pediatric femoral shaft fractures on the long-term pediatric femoral development.Materials and Methods: Thirty-five patients with a mean age of 62.1 months(15-160) who underwent surgery with titanium elastic nailing following unilateral femoral shaft fracture in our clinic were included in this study..At the last postoperative visit, patients were further evaluated through the physical examination and comparative femoral anterior posterior and lateral radiographs.The difference in length of the lower extremities and deformities in the frontal and sagittal plane, collodiaphyseal angle, mechanical distal femoral lateral angles were all calculated and compared with the intact femoral length and angles. Results: The mean follow-up period in our study was 69.8 months (36-120).The mean fracture union time period was 11.2 weeks(8-13).The mean implant removal time was 5.1months(2-12).At the last follow-up, 1 patient(2.8%) had 5mm shortening in the femur lenght while 3 patients’ femurs(8.5%) got longer with the average of 6 ± 4mm compared to that of the intact femur. In 8 patients (22.8%), varus angulation was measured as 4.7°± 2.1 at the fracture line. Conclusion: The treatment of femoral shaft fractures with titanium elastic nailing surgery has a limited effect on pediatric femur development in the long term. Surgical treatment of pediatric femoral fractures with titanium elastic nailing is a simple and safe method of treatment with low long-term complications.
L-carnitine effects in CCl4-nephrotoxicity: Immunohistochemical evaluation of glomerular nephrin and HIF-1alpha expressions
Authors: KARABULUT Derya , ÖZTÜRK Emel , AKİN Ali Tuğrul , LEKESİZCAN Ayça , ÜNSAL Hacı Murat , ÖZYAZGAN Tuğçe Merve , SAYAN Meryem
Published: May 2020

Purpose: In this study, we aimed to demonstrate the effects of L-carnitine after carbontetrachloride (CCl4) toxicity through nephrin and Hypoxia inducible factor-1 alpha (HIF-1α) expressions in the glomerular structure.Materials and Methods: Forty male Sprague dawley rats were divided into 5 groups with animals in each group. Group I: Control group; 0.2 ml olive oil intraperitoneal (ip) twice weekly, Group II: L-carnitine group; 200 mg/kg L-carnitine (ip) twice a week, Group III: CCl4 group; 0.2 ml CCl4 (ip) twice a week for 6 weeks, Group IV: L-carnitine + CCl4 group, 200 mg/kg ip L-carnitine 24 hours before CCl4 twice a week, Group V: CCl4 + L-carnitine group; 200 mg/kg L-carnitine half an hour after CCl4 twice a week. Immunohistochemical staining was performed on kidney tissue sections to show nephrin and HIF-1α expression. Expression densities of the proteins were measured by ImageJ program.Results: Nephrin expression was significantly increased in Group III compared to other groups. There was a significant increase in HIF-1α expression only between Group I and Group III. Expression densities of proteins in L-carnitine-treated groups were similar to control.Conclusion: L-carnitine has both protective and therapeutic effects against CCl4 toxicity in renal glomeruli.
Alpha-synuclein levels in multiple sclerosis patients with restless leg syndrome
Authors: ÇAKINA Suat , YÜCEL Selma , POLAT Cemre Çağan , ÖZTÜRK Şamil
Published: May 2020

Purpose: The restless legs syndrome is more frequent and critical in Multiple Sclerosis patients, and it harms their general well-being and life quality. Alpha-synuclein is a synuclein protein that can have an impact on the pathway of signaling, affecting the Dopamin 2 receptor and its receptor trafficking. Studies have shown that the decrease in dopamine 2 receptor and Restless Legs Syndrome disease are correlated. This study is aimed to ascertain the alpha-synuclein level in multiple sclerosis patients with restless legs syndrome.Materials and Methods: We took blood samples from 40 multiple sclerosis patients and 20 healthy individuals. Half of the patient group had Multiple Sclerosis with restless leg syndrome. In the study groups, the alpha-synuclein level was determined by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-dependent immunosorbent assay (ELISA).Results: Alpha-synuclein gene expression level was found or be significantly lower in restless leg syndrome patients with multiple sclerosis than the Alpha-synuclein gene expression level in the control group. Conclusion: Alpha-synuclein may have an impact on the pathogenesis of the restless leg syndrome of multiple sclerosis disease. Further investigations are required to determine the impact of alpha-synuclein in the pathogenesis of restless leg syndrome in multiple sclerosis disease.
Comparison of the modified Seldinger and trocar techniques in the percutaneous treatment of CE1 and CE3a hepatic hydatid cysts
Authors: TURGUT Bekir , BARAN Nahide
Published: May 2020

Purpose: The aim of this study was to compare the long-term results of the trocar and modified Seldinger techniques used in the percutaneous treatment of type CE1 and CE3a hepatic hydatid cysts.Materials and Methods: The data of the patients with CE1 and CE3a hydatid cysts, treated by the catheterization technique between January 2015 and June 2019 were reviewed retrospectively. Cyst type, cyst size and localization, treatment method applied, duration of catheterization and length of hospital stay were recorded. Follow-up period, cyst size at the last follow-up, and inactivation time were listed using the follow-up ultrasound reports. All of these variables were listed separately in the modified Seldinger and trocar techniques and compared statistically. Results: The data of 126 CE1 and CE3a patients were included in the study. The modified Seldinger technique was used in 36 patients, and the trocar technique was used in 90 patients. The mean follow-up period was 1185.36 ± 426.02 days. The efficacy of the treatment was at the rate of 97.2% in the modified Seldinger technique and 97.7% in the trocar technique. In total, recurrence was seen in 2.3% of the patients. The duration of catheterization and length of hospital stay were found to be significantly lower in the trocar technique compared to the modified Seldinger technique. The inactivation process was faster in the modified Seldinger technique. Conclusion: Both the modified Seldinger and trocar techniques are effective treatment modalities that can be used safely in the treatment of CE1 and CE3a hepatic hydatid cysts.
Investigation of benfotiamine’s protective effects on liver tissue in experimental carbon tetrachloride induced liver injury
Authors: KARAKAYA Bülent , KULOĞLU Tuncay , ÖNALAN Erhan , KAYA TEKTEMUR Nalan , DÖNDER Emir
Published: May 2020

Purpose: In this study, we aimed to investigate the protective effects of benfotiamine on experimental liver injury caused by carbon tetrachloride (CCl4).Materials and Methods: In this study, 30 male Wistar albino rats were used. Rats were equally divided into 5 groups. No application was made to control group. The CCl4 group was injected i.p with1ml/kg CCl4:olive oil (1:2) mixture on the 1st and 8th days, and the CCl4+benfotiamine group was treated i.p with 1 ml/kg CCl4: olive oil (1:2) mixture twice on the 1st and 8th days and orally with 70 mg/kg/day benfotiamine. To the benfotiamine group, 70 mg/kg/day benfotiamine was given orally for 14 days. To the olive oil group, 2 ml/kg olive oil was given i.p. on 1st and 8th days. Finally, rats were decapitated. Liver tissues were removed and paraffin blocks were prepared. Tissues were stored at –80 oC for malonaldeyhde (MDA) assay.Results: There were no significant differences between the control, benfotiamine and olive oil groups. Compared with the control group, there was a significant increase in MDA, apoptosis and bax immunoreactivity in CCl4 group. Compared with the CCl4 group, there was a significant decrease in MDA, apoptosis and bax immunoreactivity in the CCl4+benfotiamine group.Conclusion: CCl4 increases MDA, apoptosis and bax immunoreactivity, and benfotiamine, given as treatment, reduces these parameters.
Plasma expression and methylation levels of vascular endothelial growth factor (VEGF-C) and basic fibroblast growth factor (bFGF) in children with acute lymphoblastic leukemia in Çukurova Region, Turkey
Authors: İNANDIKLIOGLU Nihal , DEMİRHAN Osman , BAYRAM İbrahim , TANYELİ Atila
Published: May 2020

Purpose: The aim of this study was to determine the expression and methylation levels of vascular endothelial growth factor-C (VEGF-C) and basic fibroblast growth factor (bFGF) in children with acute lymphoblastic leukemia (ALL).Materials and Methods: We detected mRNA expression profiles and methylation levels of VEGF-C and bFGF genes in the peripheral blood samples of 26 patients with newly diagnosed ALL and 26 healthy controls by real-time quantitative PCR. Results: The expression level of bFGF was significantly increased (4.23-fold) in ALL patients as compared with controls. Moreover, VEGF-C were significantly decreased (3.41-fold) in ALL patients as compared with controls. The methylation of the promoter region of VEGF-C (6.88%) and bFGF (16.64%) genes was higher in ALL patients than in healthy controls. Conclusion: Long-term changes in VEGF-C and bFGF at different time intervals as a result of years of follow-up of patients may show stronger associations with disease risk. Further studies are required to establish strong links with both VEGF-C and bFGF, and ALL risk factors.
Sjögren’s syndrome and catastrophic antiphospholipid syndrome with severe skin involvement
Authors: KARAGÜN Ebru , ÖNEÇ Birgül , AKBAŞ Türkay , GAMSIZKAN Mehmet
Published: May 2020

Catastrophic antiphospholipid syndrome is a rare but rapidly progressing form of antiphospholipid antibody syndrome with high mortality. The syndrome causes multiorgan failure associated with diffuse micro-thromboses. Necrotic-appearing ecchymotic lesions emerging from the distal aspect of both lower extremities and progressing to the upper leg region, and to the upper extremities developed in a 58-year-old woman. Histopathological examination of the biopsy specimen revealed intravascular microthrombi in the dermis. Laboratory findings for anti-cardiolipin antibodies IgM and lupus anticoagulant resulted positive. Lung and kidney involvement was observed. The clinical course progressed very quickly, and catastrophic antiphospholipid syndrome was diagnosed with these findings. Two-thirds of catastrophic antiphospholipid syndrome cases develop due to secondary causes, the most common being infections. Catastrophic antiphospholipid syndrome may also accompany autoimmune diseases, particularly systemic lupus erythematosus. This report is presented to emphasize that Sjögren's syndrome should be considered in the etiology of catastrophic antiphospholipid syndrome.
Birinci basamakta reçeteleme trendi ve sık karşılaşılan tanılara ait reçetelerin incelenmesi: Türkiye verisi
Authors: BAYRAM Dilara , VIZDIKLAR Caner , AYDIN Volkan , İŞLİ Fatma , AKICI Ahmet
Published: May 2020

Amaç: Bu çalışmada Türkiye’de birinci basamakta düzenlenen reçetelerin ayrıntılarının incelenmesi ve bunların yıllara göre değişiminin değerlendirilmesi amaçlandı.Gereç ve Yöntem: Türkiye’de 2013-2016 tarihleri arasında birinci basamak hekimleri tarafından yazılan ve Reçete Bilgi Sistemi’nde kayıtlı tüm elektronik reçetelerdeki ilaçların ayrıntıları incelendi. Hastaların cinsiyetleri ve yaş grupları özelinde reçete başına düşen ortalama ilaç sayıları (RBDİS) belirlendi. İncelenen yıllarda en sık karşılaşılan ilk yirmi ilacın yer aldığı reçetelerin yüzdeleri belirlendi. Dört yıllık süreçte tek tanılı reçeteler içerisinde en sık karşılaşılan on tanının yer aldığı reçetelerin yüzdesi ve RBDİS incelendi. Bulgular: Dört yılın toplamında 518.335.821 adet reçetede 1.457.034.275 kalem ilaç reçetelendiği ve RBDİS’nin 2,81 olduğu tespit edildi. Tüm yıllarda reçetelerde en fazla yer alan ilaçlar “diğer soğuk algınlığı preparatları” (%19,2-%19,7) ve “amoksisilin+beta-laktamaz inhibitörü” (%9,9-%10,5) idi. Dört yılın toplamında tek tanılı reçetelerde hipertansiyon (%6,9, RBDİS: 2,00) ve “akut üst solunum yolu enfeksiyonu, tanımlanmamış” (ÜSYE), (%6,5, RBDİS: 2,61) tanıları ilk sıralardaydı.Sonuç: Birinci basamaktaki reçetelerin daha çok kadınlara ve yaşlılara yazıldığı ve ÜSYE ile hipertansiyon endikasyon alanlarında yoğunlaştığı anlaşılmaktadır. Soğuk algınlığı preparatları, NSAİİ’ler, PPİ’ler, analjezikler ve geniş spektrumlu antibiyotiklerin fazla reçeteleniyor olması birinci basamakta rasyonel reçeteleme davranışı ile ilgili önemli sorunların varlığına işaret etmektedir.
Effect of physical activity on health-related quality of life and depression anxiety in pregnancy
Authors: YILDIRIM Duygu İlke , BALCI Şule , GÜNENÇ Oğuzhan , ERYILMAZ Mehmet Ali
Published: May 2020

Purpose: The study aimed to investigate the effect of physical activity on health-related quality of life and depression-anxiety in pregnancy.Materials and Methods: This is a descriptive and cross-sectional study. The study included 347 pregnant women who were admitted to the gynecology and obstetrics outpatient polyclinic. The quality of life of the pregnant women was collected using the Nottingham Health Profile scale, physical activity levels were collected by using the short form of the International Physical Activity Questionnaire and data on depression and anxiety levels of the participants were collected using the Beck Depression Inventory and the Beck Anxiety Inventory.Results: When physical activity levels of pregnant women were compared according to Nottingham Health Profile scale and quality of life subscales; there were statistically significant differences between physical activity levels and energy level, social isolation, emotional status, sleep and total Nottingham Health Profile score. There was a significant relationship between low (a) - high (c) and middle (b) - high (c) groups when anxiety levels were compared with physical activity levels. Conclusion: The results of our study are considered to act as a guideline for the regulation and necessity of physical activity in pregnant women.
Recurrent ameloblastoma of anterior mandible
Authors: NAIR Mithula , SHETTY Vikram , AJİLA Vidya , HEGDE Shruthi
Published: May 2020

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Koksartrozda uygulanan çimentosuz total kalça protezinin klinik sonuçları
Authors: BAĞIR Melih , YILMAZ Ahmet
Published: May 2020

Amaç: Total kalça protezi uygulamalarında çimentolu, çimentosuz ve hibrid tespit yöntemlerinin sonuçları tartışılmaya devam etmektedir. Çalışmamızın amacı, çimentosuz total kalça protezi olgularımızın klinik ve radyolojik sonuçlarını literatür eşliğinde değerlendirmektir. Gereç ve Yöntem: Çalışmamızda çimentosuz total kalça protezi uygulanan olgular geriye dönük olarak değerlendirildi. En az 1 yıllık takibi olan 80 hastanın 95 kalçası çalışmaya dahil edildi. Klinik değerlendirmede Harris kalça skoru (HKS) kullanıldı. Radyolojik değerlendirmede ise komponentlerin malpozisyonuna ve gevşemeye bakıldı. Ayrıca hastalar heterotopik ossifikasyon, dislokasyon ve diğer komplikasyonlar açısından incelendi.Bulgular: Hastaların 47 (%58.7)’si kadın, 33 (%41.3)’ü erkekti. Olguların yaş ortalaması 52.312.8 idi. Otuz altı (%45) hastada sağ kalça, 29 (%36) hastada sol kalça ve 15 (%18.7) hastada bilateral kalça protezi uygulandı. Cerrahi yaklaşım olarak, hastaların 74 (%77.9)’ünde posterolateral, 21 (%22.1)’inde anterolateral insizyon kullanıldı. Ortalama takip süresi 3818.8 ay idi. Hastaların ameliyat öncesi ve son kontroldeki toplam Harris kalça skorları sırasıyla 28.5210.93 ve 87.097.03 idi. Radyolojik değerlendirmede hastaların 12 (%12.6)’sinde asetabuler malpozisyon tespit edildi. Hastaların 8 (%8.4)’inde intraoperatif kırık saptandı. Sonuç: Çimentosuz total kalça protezi uyguladığımız hastalarımızda, kısa ve orta dönemde Harris kalça skoru değerlendirmesine göre başarılı klinik sonuçlar elde edilmiştir. Çimentosuz tespitte erken dönemde sıkı stabilizasyon sağlanır, fakat intraoperatif kırık ve asetabuler komponentlerin malpozisyonu açısından dikkatli olunmalıdır.
Effect of a mobilization program administered after open cholecystectomy on sleep duration and several other clinical variables
Authors: ALDEMİR Kadriye , AYDIN SAYILAN Aylin
Published: May 2020

Purpose: The purpose of this study was to determine the effect on sleep duration, pain level, first flatus and defecation time, and discharge of a mobilization program administered under nurse supervision and monitoring following open cholecystectomy.Materials and Methods: This experimental study was performed in February-August 2019 in the general surgery clinic of a public hospital. Considering the possibility of data loss, 68 patients meeting the research criteria were included. Two patients from the experimental group and two from the control group subsequently dropped out, and the study was finally completed with 64 patients. Data were collected using a patient description form, a Visual Analogue Scale, and a walking chart on which pedometer output was recorded. Results: Length of hospitalization was shorter, first flatus and defecation time occurred earlier, and walking distances were longer in the experimental group compared to the control group. No difference was determined between the groups in terms of amount of drainage, or times to spontaneous urination. It was determined that the pain levels in the control were lower than those in the experimental group on postoperative day 1, and sleep durations on postoperative days 2 and 3 were significantly longer.Conclusion: Earlier first flatus, defecation time, and discharge, and significantly longer walking distances, were determined in the experimental group compared to the control group. However, the mobilization program had no effect on sleep duration or pain levels.
Determination of sella turcica types in healthy Turkish population
Authors: ÖZANDAÇ POLAT Sema , KABAKCI Ayşe Gül , ÖKSÜZLER Fatma Yasemin , OKSÜZLER Mahmut , YÜCEL Ahmet Hilmi
Published: May 2020

Purpose: The aim of this study was to determine the age and gender differences of sella turcica types in healthy Turkish individuals using lateral cephalometric radiographs and make an analysis of sella turcica types. Material and Methods: A total of 222 patients of which 93 females and 129 males in the age group of 1-46 years who applying to the Department of Radiology with various reasons were included in our study and the classification of sella turcica types was assessed. Measurements were classified both in terms of gender, and age groups. Sella turcica types were analysed according to the two classification methods performed by Meyer Marcotti et al., and Axelsson et al. Results: Significant differences were found between gender and sella turcica types according to Axelsson et al’s classification method. Furthermore, the sella turcica bridging type in males and variation combination type in females were no found. On the other hand, there were no considerable differences between sella turcica types and age groups according to Axelsson et al’s classification; whereas, the significant difference was found between age groups and sella turcica types according to Meyer Marcotti et al’s classification. Conclusion: The data obtained in our study will shed light on monitorize of growth of individual by enabling determination of the sella turcica types in various diseases and different age groups, and the knowledge of the anatomic variations for sella turcica typology of Turkish population.
Osteoartriti olan hastalarda bedensel belirtileri abartma, anksiyete-depresyon ve durumluk anksiyete düzeyleri
Authors: KULU Müberra , ÖZSOY Filiz , KORKMAZ Murat
Published: May 2020

Amaç: Bu çalışmda kronik ağrılı bir hastalık olan osteoartrit (OA) tanısı ile cerrahi girişim planlanan hastaların anksiyete-depresyon ve bedenselleştirme düzeylerini değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: OA tanısı ile cerrahi girişim planlanan hastalar ve hasta grubu demografik veriler açısından eşleşebilecek kişiler sağlıklı kontrol grubu olarak çalışmamıza dahil edildi. Tüm katılımcılara sosyodemografik veri formu, Hastane Anksiyete Depresyon Ölçeği (HADÖ), Penn Durumsal Anksiyete Ölçeği (PDAÖ), Bedensel Duyumları Büyütme Ölçeği (BDBÖ) uygulandı. Bulgular: Çalışmamıza 64 kişi dahil edilmiştir. Hastaların yaş ortalaması 64.77±8.14 iken, sağlıklı kontrol grubunun 65.22±9.15 olarak hesaplanmıştır. Nicel değişkenler arasındaki ilişki incelendiğinde; HADÖ için OA hastalarının hem anksiyete, hem depresyon alt boyutu hem de ölçeğin total puanında kontrol grubundan yüksek sonuçlar aldığı görülmüştür. PDAÖ ve BDBÖ için de hasta grubun sağlıklı kontrollere göre aldıkları skorlar çok daha yüksekti. Sonuç: Elde ettiğimiz sonuçlarda; kronik ağrılı bir hastalık olan OA hastalarının cerrahi öncesi anksiyete-depresyon ve bedenselleştirme skorlarının fazla olduğu tespit edildi. Bu bulgulardan yola çıkarak; OA hastalarının hem hastalık seyrinde hem de cerrahi girişim öncesi, hastalara daha fazla yardımcı olabilmek, cerrahiye uyumlarını kolaylaştırabilmek için psikososyal olarak iyi desteklenmeleri önerilmektedir.
Beliefs and experiences of breast cancer patients about the use of complementary therapies: A qualitative study
Authors: TUZCU Ayla , İPEK Merve
Published: May 2020

Purpose: Breast cancer patients prefer to use complementary therapies (CT) along with medical treatment to improve their health. However, patients don’t share detailed information regarding the use of CT with healthcare professionals. The aim of this study is to examine the beliefs and experiences of breast cancer patients receiving chemotherapy regarding the use of CT.Materials and Methods: Individual interviews were conducted with 11 breast cancer patients through a semi-structured interview form in June-July 2019. Six-phase thematic analysis was used to analyze the data.Results: Three main themes were identified in the study: Types of CT used, CT preferences, and positive experiences. In terms of CT types, patients use natural products, and mind and body practices. Patients prefer these methods to prevent the progression of the disease, not to use medical drugs, reduce the side effects of the treatment, or because they don’t believe in the therapeutic effect of chemotherapy. Physiological recovery and immunity enhancement are among the positive experiences after the use of CT. Patients continue to use these methods because they have positive experiences related to the use of CT.Conclusion: Breast cancer patients mostly prefer natural products followed by mind and body practices. Patients receive very little guidance from healthcare professionals regarding the use of CT and prefer to use social communication resources for such information. Advices given by oncology physicians and nurses to the patients in the light of the current evidence-based literature whether to continue using CT are crucial for the health of the patient.
Rare presentation of a posterior mediastinal cystic schwannoma
Authors: TANRIVERMİŞ SAYIT Aslı , ELMALİ M
Published: May 2020

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Talasemi hastalarında demir yükü ile kardiyovasküler fonksiyonların ekokardiyografik indekslerle korelasyon çalışması
Authors: AKKUŞ Gamze , AKKUŞ Oğuz , NAS Kamil , ACARTÜRK Esmeray , GÜRKAN Emel
Published: May 2020

Amaç: Bu çalışmada talasemi majör ve intermedia hastalarında arteryel sertlik parametrelerinin ekokardiyografik ve osilometrik (arteriograf) yöntemlerle incelenmesi amaçlanmıştır.Gereç ve Yöntem: Çalışmaya her iki cinsiyetten 44 gönüllü katılımcı (24 talasemi hastası, 20 kontrol grubu) alındı. Hastaların hematolojik ve hemodinamik parametreleri kayıt edildi. Arteryel sertlik göstergesi olarak aortik arttırma göstergesi (aortic AG), nabız dalga hızı (NDH), aortic strain, distensibilite ve aortic sertlik indeksi bakıldı. Nabız dalga hızı ve aortic AG arteriyograf ile diğer parametreler ekokardiyografik olarak ölçüldü.Bulgular: Vasküler kompliyans belirleyicisi olarak bakılan parametrelerden aortik strain ve arteryel sertlik indeksi iki grup arasında anlamlı saptanmıştır. Aort nabız dalga hızı talasemi hasta grubunda sınırda anlamlı saptandı. Doku doppler ölçümlerinden erken (E‟) ve geç (A‟) mitral anüler diyastolik doluş hızları beta talasemi hastalarında kontrol grubuna göre anlamlı düşük saptandı.Sonuç: Ekokardiyografik doku doppler değerlendirmesi talasemi hastalarında diyastolik disfonksiyon gelişimini belirlemede yararlı bulunmuştur. Arteryel sertlik indeksleri, özellikle aortic strain, arteryel sertlik indeksi ve nabız dalga hızı, talasemi hastalarında demir birikimine bağlı vasküler yaşlanmayı belirlemede başvurulabilecek kolay ve güvenilir ölçümlerdir.
Ensuring safe repatriation of the citizens amidst the threat of Corona Virus Disease 2019 Pandemic
Authors: SHRİVASTAVA Saurabh , SHRİVASTAVA Prateek
Published: May 2020

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Envisaging employment of the non-pharmaceutical interventions in the effective containment of the COVID-19 pandemic
Authors: SHRİVASTAVA Saurabh , SHRİVASTAVA Prateek
Published: May 2020

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Bazı Armut Klon Anaçları Üzerine Aşılı Armut Çeşitlerinin Fidan Gelişim Performanslarının Belirlenmesi
Authors: SERTTAŞ Sevgi , ÖZTÜRK Ahmet
Published: May 2020

Bu çalışma, 2018-2019 yılları arasında bazı armut klon anaçları üzerine aşılı armut çeşitlerinin aşı başarısı ve fidan gelişim performanslarını belirlemek amacıyla yürütülmüştür. Bu çalışmada, ‘Deveci’, ‘Williams’, ‘Santa Maria’ ve ‘Abate Fetel’ armut çeşitleri Fox9, Fox11, OHxF87 ve OHxF333 armut klon anaçları üzerine dilciksiz aşı yöntemiyle Nisan ayında aşılanmıştır. Çalışmada anaçların aşı tutma oranı üzerine etkisi olmazken aşı sürme ve fidan yaşama oranı ile aşı sürgün çapı ve sürgün uzunluğu üzerine etkisinin ortalamalar bakımından önemli olduğu tespit edilmiştir. Çeşitlerin, aşı sürgün çapı hariç aşı tutma, sürme ve fidanların yaşama oranı ile sürgün uzunluğu üzerine etkisinin ortalamalar bakımından önemli olduğu saptanmıştır. Araştırmada aşı tutma oranın %86.7-%100, aşı sürme oranın %80.0-%100, fidan yaşama oranının %77.8-%100 arasında olduğu belirlenmiştir. Aşı tutma ve aşı sürme oranları bakımından ‘Santa Maria’ ve ‘Deveci’ çeşitleri en iyi sonucu vermiştir. En yüksek fidan yaşama oranı ‘Santa Maria’ ve ‘Deveci’, en düşük ise ‘Williams’ çeşidinde belirlenmiştir. Araştırmada aşı sürgünü uzunluğunun 96.4 cm-135.5 cm, aşı sürgünü çapının 17.60 mm-20.94 mm arasında olduğu belirlenmiştir. Araştırmada anaçlar bakımından en uzun aşı sürgünü Fox9 en kısa ise OHxF333 anaçlarında belirlenmiştir. Çeşitler bakımından ise aşı sürgün uzunluğunun ‘Santa Maria’ çeşidinde diğer çeşitlerden daha fazla olduğu belirlenmiştir. Araştırmada ‘Deveci’ ve ‘Santa Maria’ için Fox11 ve OHxF87; ‘Williams’ için Fox11 ve OHxF333; ‘Abate Fetel’ için Fox9 ve OHxF87 anaçları tavsiye edilebilir. Bu çalışma sonucunda armut yetiştiriciliğinde büyüme, verim ve kalite bakımından oldukça önemli olan kaliteli aşılı fidan üretiminin sürgün dönemde başarılı bir şekilde yapılabileceği ortaya konulmuştur.
Apuntes sobre el proceso de entrega de bien inmueble arrendado iniciado en virtud del incumplimiento de un acta de conciliación
Authors: Maestre Luis E
Published: May 2020

El presente artículo pretende explicar de manera sucinta en que consiste el proceso de comisión de entrega de bien inmueble arrendado, sus beneficios y ventajas frente al proceso declarativo de restitución de inmueble.
Q & A with Paul Paterson
Authors: Paterson Paul
Published: May 2020

Paul Paterson, recently appointed Chief Economist at the Australian Department of Communications, describes the role of the new Bureau of Communications Research.
A prospective study to determine the accuracy of triple test score in breast lump
Authors: Pandey Vinod Kumar , Yadav Sarvesh , Mishra Shirish , Singh Rohit , Tripathi Ankur Dutt
Published: May 2020

Background: Breast cancer is the most common cancer in women worldwide. The commonest mode of presentation of diseases of the breast is lump. It is the most common site-specific cancer in women. Triple test score which includes clinical breast examination, mammogram, FNAC score. A simple non-invasive but reliable test can make a huge difference in management between benign and malignant lumps. Aims and objectives of the study were to differentiate between benign and malignant lesions based on TTS and correlated the accuracy of triple test score with histopathology report, and plan the management accordingly.Methods: A prospective study was carried out in which TTS was calculated by summation of individuals’ scores of all three components and compare with histopathology report.Results: In present study of 74 patients (age group of 30 to 65 years), based on TT score 52 benign, 12 malignant, and 10 suspicious (neither benign nor malignant). But the final histopathological result showed 59 as benign and 15 as malignant, which is in concordant with TTS, which shows the accuracy of up to 100%. Out of 10 (suspicious) which were dis-concordant, 7 are benign and 3 are malignant on histopathology.Conclusions: By use of the triple test score and its interpretation, definitive treatment can be initiated, which would reduce the need for unnecessary biopsy and its ability to predict benign lump, can avoid major surgery.
Rare finding of a large cell poorly differentiated neuroendocrine tumor in the colon
Authors: Luster Stephanie A. , Kakish Daniel K. , Gill Manroop , Kumthekar Narendra
Published: May 2020

A 43 year old female presented to the emergency department for nausea, vomiting and abdominal pain secondary to a bowel obstruction subsequently revealed to be a poorly differentiated large cell neuroendocrine tumor of the colon. After a CT scan showed a mass in the ascending colon with possible metastasis to the right lobe of the liver, an exploratory laparotomy was performed. A hemicolectomy was performed with biopsy of the liver mass. Pathology was consistent with large cell neuroendocrine tumor in all specimens including the liver biopsy, ascending colon, and transverse colon. Although large cell neuroendocrine tumors of the colon are a rare malignancy, they are an important consideration in the workup of multiple colonic masses with metastases, especially in patients presenting with bowel obstruction. The literature on poorly differentiated large cell neuroendocrine cancer and treatment is reviewed. Poorly differentiated large cell neuroendocrine tumor is a rare pathology but should be included in the differential diagnosis in patients presenting with a colon mass and bowel obstruction.