bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrasound-guided microwave ablation for treatment of lip cancer
Authors: Wei Ting , Lu Man , Wang Lu , Xu Jinshun , Zhuang Min
Published: December 2023

Lip and oral cavity cancer is a severe and growing problem, ranked 16th for both incidence and mortality worldwide. These malignancies are mainly treated with surgery, which can cause a wide range of sequelae. Despite ultrasound-guided microwave ablation (MWA) being widely used, there is no report concerning its application in lip cancer. This study presents a case of ultrasound-guided MWA in a 97-year-old man with squamous cell carcinoma (SCC) and lymph node metastases under the lower lip. The patient was unsuitable for surgery due to his older age. At the most recent 1-year follow-up after treatment, the patient remained in good condition with no symptoms of dysphagia or slurred speech, and the cosmetic results were excellent. Based on clinical evaluation and radiographic imaging, there was no evidence of metastasis or recurrence. Ultrasound-guided MWA could be a promising option for the management of lip cancer.
An AMPK agonist suppresses the progress of colorectal cancer by regulating the polarization of TAM to M1 through inhibition of HIF-1α and mTOR signal pathway
Authors: Cao Yuanyuan , Wo Mingyi , Xu Chan , Fei Xianming , Jin Juan , Shan Zhiming
Published: December 2023

Objective:

This study aimed to evaluate the impact of an adenosine monophosphate-activated protein kinase (AMPK) agonist, metformin (MET), on the antitumor effects of macrophages and to determine the underlying mechanism involved in the process.

Materials and Methods:

M0 macrophages were derived from phorbol-12-myristate-13-acetate-stimulated THP-1 cells.

Results:

The levels of tumor necrosis factor-alpha (TNF-α) and human leukocyte antigen-DR (HLA-DR) were decreased in macrophages incubated with HCT116 cells, whereas those of arginase-1 (Arg-1), CD163, and CD206 were elevated; these effects were reversed by MET. The transfection of small interfering (si) RNA abrogated the influence of MET on the expression of the M1/M2 macrophage biomarkers. MET significantly suppressed the proliferation and migration abilities of HCT116 cells incubated with M0 macrophages; these actions were reversed by siRNA transfection against AMPK. The hypoxia-inducible factor 1-alpha (HIF-1α), phosphorylated protein kinase B (p-AKT), and phosphorylated mammalian target of rapamycin (p-mTOR) levels were reduced by the introduction of MET and promoted by siRNA transfection against AMPK. In addition, the levels of HIF-1α, p-AKT, and p-mTOR suppressed by MET were markedly increased following the transfection of siRNA against AMPK.

Conclusion:

These findings indicate that MET can repress the progression of colorectal cancer by transforming tumor-associated macrophages to the M1phenotype via inhibition of the HIF-1α and mTOR signaling pathways.
Comparison of TNM AJCC/UICC 8th with JES 11th staging systems for prognostic prediction in patients with esophageal squamous cell carcinoma who underwent radical (chemo) radiotherapy in China
Authors: Zhang Andu , Li Yang , Zhang Hongtao , Liu Hui , Han Chun , Shi Gaofeng
Published: December 2023

Objective:

The aim of the study was to compare the prognostic prediction performances of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) 8th staging system and the Japan Esophageal Society (JES) 11th staging system for patients with esophageal squamous cell carcinoma who underwent radical (chemo) radiotherapy.

Methods:

In total, 574 patients were enrolled and categorized according to the tumor, node metastasis (TNM) AJCC/UICC 8th and JES 11th editions. Survival rates and disease-free survival were computed using the Kaplan–Meier technique. The log-rank test was used for survival difference analysis.

Results:

(1) The 8th AJCC/UICC N staging exhibited significant stratification for overall survival (OS) and progression-free survival (PFS). JES 11th showed significant OS stratification, but PFS was not well-stratified for N2–N4. (2) Both staging systems demonstrated significant stratification for OS and PFS. (3) AJCC/UICC 8th TNM staging yielded significantly well-stratified OS and PFS in the differing staging group. JES 11th failed to stratify OS and PFS for stages III and IVA. (4) AJCC/UICC 8th TNM stratified OS and PFS significantly well for lower and middle region tumors, whereas JES 11th inadequately stratified stages III and IVA. (5) Significant multivariable analysis results indicated that AJCC/UICC 8th independently predicted poor OS and PFS.

Conclusions:

In Chinese patients with esophageal squamous cell carcinoma who underwent radical (chemo) radiotherapy, the AJCC/UICC 8th edition exhibited superior prognostic prediction capabilities compared with the JES 11th edition.
E3 ubiquitin-ligase RNF138 may regulate p53 protein expression to regulate the self-renewal and tumorigenicity of glioma stem cells
Authors: Chao Qing , Li Xuetao , Huang Yulun
Published: December 2023

Background:

Glioblastoma multiforme (GBM), the most malignant tumor of the central nervous system, is characterized by poor survival and high recurrence. Glioma stem cells (GSCs) are key to treating GBM and are regulated by various signaling pathways. Ubiquitination, a post-translational modification, plays an important regulatory role in many biological processes. Ring finger protein 138 (RNF138) is an E3 ubiquitin-protein ligase that is highly expressed in several tumors; however, its role in GBM is unclear. This study investigated whether RNF138 regulates the self-renewal ability of glioma stem GSCs to treat GBM.

Materials and Methods:

The expression of RNF138 in glioma tissues and its correlation with GSCs were analyzed using bioinformatics. Short hairpin ribonucleic acid (RNA) was designed to downregulate the expression of RNF138 in GSCs, and immunofluorescence, secondary pellet formation, and western blotting were used to detect changes in GSC markers and self-renewal ability. The effects of RNF138 on p53 protein expression were determined by immunofluorescence and western blotting. The effects of RNF138 on the self-renewal and tumorigenic abilities of GSCs were evaluated in vivo.

Results:

RNF138 expression was higher in glioma tissues than in normal brain tissues, and was highly expressed in GSCs. RNF138 downregulation significantly decreased the expression of the GSC markers cluster of differentiation 133 (CD133) and nestin. Mechanistically, RNF138 may interfere with the self-renewal ability of GSCs by regulating the expression of p53. RNF138 downregulation in vivo prolonged survival time and regulated the expression of p53 protein in tumor-bearing mice.

Conclusion:

RNF138 may regulate the expression of p53 protein through ubiquitination, thereby affecting the self-renewal and tumorigenic ability of GSCs. This study provides a scientific basis for the treatment of glioblastoma by targeting RNF138 to inhibit GSCs.
Upshots of health education among patients with type 2 diabetes mellitus: A field study in Mysuru
Authors: Anil Deepak , Kumar D. Sunil , Ravali Annaram , Vadaga Vijaylakshmi Rao , Gopi Arun
Published: December 2023

Objective:

This study was conducted to assess the impact of health education on lifestyle modification and disease status of diabetic patients for 6 months in rural Mysuru in Southern India.

Materials and Methods:

A quasi-experimental study was conducted among 104 patients with type 2 diabetes mellitus in rural Mysuru, India from July to December 2022. Participants were assigned to two groups: intervention (n = 52) and control (n = 52), and their data were collected. The intervention group was educated about the disease and its management and was given printed pamphlets containing information to be followed, whereas the participants in the control group were asked to continue their routine health checkups. The body mass index (BMI), weight, fasting blood sugar (FBS), knowledge about the disease, and behavior changes were recorded and compared between the two groups before and after 6 months.

Results:

The mean FBS value, BMI and weight decreased significantly in the intervention group after 6 months (FBS: 164.79 ± 47.59 mg/dL vs. 141.92 ± 25.63 mg/dL, P < 0.001; BMI: 22.97 ± 3.75 kg/m2 vs. 22.62 ± 3.29 kg/m2, P < 0.05; weight: 62.82 ± 11.92 kg vs. 61.54 ± 10.67 kg, P < 0.05). The posttest period also showed an improvement in physical activity, diet, and medication adherence in the intervention group compared to the control group (P < 0.05). The knowledge scores also improved postintervention which was statistically significant with the Wilcoxon signed-rank test (P < 0.05).

Conclusions:

The effectiveness of the educational intervention was also supported by lower FBS levels and decrease in BMI and weight compared to before. The findings of this study may help and make it easier to plan studies on people with diabetes mellitus in various settings.
Scope of technology in health care, special focus on nursing
Authors: Malla Adil Mudasir , Amin Ulfat
Published: December 2023

Integrating artificial intelligence (AI) into health care reshapes nursing practices and education, enhancing patient care and clinical processes. This article discusses the transformative potential of AI in nursing, from streamlining documentation and diagnosis using AI applications to the evolution of nursing. The utilization of AI in primary care through automated communication strategies and the emergence of humanistic AI solutions are explored. As nurses adapt to AI-driven health-care technologies, balancing present needs with future demands becomes imperative. AI provides substantial advantages, but it’s crucial to address challenges to ensure the successful integration of technology in healthcare and maintain the delivery of high-quality patient care in our tech-driven healthcare environment.
Evaluation of the etiologies and rehabilitation status of patients with blindness: A prospective observational study
Authors: Das Sarmistha , Halder Pankaj Kumar , Ray Suchidipa , Vadeo Akholu , Paul Kallol , Sarkar Sneha
Published: December 2023

Objective:

Preventive measures and appropriate rehabilitation are important in reducing the social burden of blindness. This study was to evaluate the etiologies, proportions, and level of rehabilitation for patients with blindness.

Materials and Methods:

A prospective observational study with 1000 visually impaired patients was conducted. The data regarding age, gender, socioeconomic status (SES), etiologies, curable or incurable blindness (IB), treatments, awareness, and state of rehabilitation were collected and reviewed.

Results:

The ratio of curable to IB was 0.82:1. The proportion of blindness rises after 40, even while the proportion of curable blindness (CB) increases after 60. The male–female ratios were 1.25:1 and 1:1.66 in the cases of CB and IB, respectively. On the other hand, the male–female ratio for childhood blindness was 1.66:1. Cataracts (78.22%) were the most common cause of CB, whereas diabetic retinopathy (24%), corneal opacity (17.5%), and trauma (12.4%) were causes of IB. Patients with illiteracy, low SES, and female gender were more likely to develop IB. There were low enrollment rates at the blind school and poor rehabilitation, mainly because of a lack of knowledge.

Conclusion:

Diabetic retinopathy, corneal opacity, and trauma are the major causes of IB. IB and poor rehabilitation were more profound in women and were associated with illiteracy, low SES, and a lack of awareness.
Lived Experiences of Intimate Partner Violence and Help-seeking among Wives of Persons with Alcohol Dependence: A Thematic Analysis
Authors: Periyasamy Chinnadurai , Ezhumalai Sinu , Vranda Mysore Narasimha , Narayanan Gitanjali , Kandasamy Arun
Published: December 2023

Background:

Worldwide, intimate partner violence (IPV) is a significant public health problem. Most of the wives of persons with alcohol dependence (PwAD) experience IPV in their lifetime. The study examined lived experiences of IPV among wives of PwAD.

Methods:

Qualitative research study design was used. Twenty participants were recruited using the consecutive sampling method. The researcher used an in-depth interview guide to collect the data. ATLAS.ti.9 software was used to analyse the qualitative data. Thematic analysis was used for coding and emerging themes. The thematic analysis yielded four themes generated from the in-depth interview: (1) reasons for the IPV, (2) help-seeking, (3) barriers in help-seeking and (4) coping with IPV.

Conclusion:

Survivors of IPV do not seek help due to self-stigma, unavailable resources, and lack of awareness about treatment for alcohol dependence. Clinicians should routinely screen for IPV among female spouses of persons with alcohol-dependent syndrome and provide psychosocial interventions for the survivors of IPV.
Internet Addiction among Undergraduate Medical Students and Its Relationship with Alexithymia, Stress, Anxiety, and Depression in an Indian Medical College: A Cross-sectional Study
Authors: Rao Suhas Bhargav Achatapalli Venkata , Kangil Sanjana Ramanath , Shivarudrappa Narendra Kumar Muthugaduru
Published: December 2023

Context:

Internet addiction (IA) is a rising issue, particularly among university students. The presence of comorbid psychiatric distress can worsen the impact of IA on academic and social functioning. Alexithymia, difficulty recognizing and expressing emotions may play a role in this relationship.

Aims:

This study aimed to assess the severity and association of IA, psychological distress, and alexithymia among undergraduate medical students in India.

Settings and Design:

This was a cross-sectional study of 380 undergraduate medical students following convenience sampling, studying in Mysore Medical College and Research Institute (MMCRI), Mysuru.

Subjects and Methods:

Sociodemographic details were collected, and participants completed the Young’s Internet Addiction Test (IAT-20), Depression, Anxiety, and Stress Scale-21 (DASS-21), and Toronto Alexithymia Scale-20 (TAS-20).

Statistical Analysis:

Statistical analysis was performed using SPSS-20. Descriptive statistics expressed as frequencies, means, and percentages. Qualitative data were analyzed using the Chi-square test to find out the association between two categorical variables. Spearman’s rank correlation test was used to find the correlation involving ordinal variables. Statistical significance was set at p<.05.

Results:

About 45.7% were aged 18–20 years, male (58.4%), and from urban areas (54.2%). On IAT, 26.6% showed mild addiction, 11.6% had moderate addiction, and 1.3% had severe dependence. Psychological distress with 42.1% experienced depression, 42.4% anxiety, and 20.0% stress symptoms. In addition, 25.0% were classified as alexithymia. Significant correlations were found between grades of depression, anxiety, stress, and alexithymia with gender, residence, psychiatric illness in family, substance, and Internet use.

Conclusions:

The study population revealed a high prevalence of IA and psychiatric distress among undergraduate medical students. These findings highlight the need for interventions and support services targeting IA and related psychological distress among medical students.
Cognitive Benefits of Physical Activity in the Elderly: A Narrative Review
Authors: Ghosh Aishwarya , Jagtap Tejaswini , Issac Thomas Gregor
Published: December 2023

A huge focus of research has been on the pharmacological trials to find drugs that work to stall the onset of age related cognitive decline and subsequent neurodegenerative disorders like dementia, but pharmacological interventions have not been able to help with cure and hence there has been a shift of focus to other nonpharmacological and behavioral interventions like physical activity (PA) along with the use of medications. There is moderate evidence supporting different forms of exercise for lowering the risk of cognitive decline and dementia. PA has positive effects on the global cognition of the elderly and helps maintain hippocampal volume. Aerobic exercise was found to be the most beneficial among different other forms of PA. Regular involvement in PA not only helps in the prevention and control of various diseases but also is increasingly recommended as a strategy to promote health and encourage the maintenance of functional capacity in the elderly. The main objective of this review is to discuss the effects of PA on brain health and cognitive functions of older adults from a psychophysiological perspective. Important underlying molecular mechanisms have also been discussed which would provide an idea of the biological basis of the same.
Desmoid of the Abdominal Wall: Mimicking an Ovarian Mass
Authors: Jassi Parveen , Attri Ankur
Published: December 2023

Abdominal wall desmoid tumors (DTs) are a rare group of fibrous tumors of soft tissues and are locally aggressive. These tumors have a strong tendency for local invasion and recurrence without any metastatic potential. In large DTs with predominantly intra-abdominal component, the origin of mass becomes difficult to predict unless a keen observation for origin is done on advanced imaging such as magnetic resonance imaging (MRI). Surgery is the optimal treatment. We report a case of DT in a 32-year-old woman with a history of cesarean section 3 years back who presented with a chief complaint of progressive mass in the lower abdomen, noticed from the last 3 to 4 months. It was diagnosed as an ovarian mass on ultrasonography, but MRI confirmed a large abdominal wall mass. Resection of the tumor was done, and histopathology revealed a spindle cell tumor favoring fibromatosis. Large-sized DTs with predominantly intra-abdominal component may be mistaken for mass with intra-abdominal origin like uterine leiomyoma and ovarian mass as seen in our case. Therefore, careful attention is to be given to the origin if the mass is large and abutting the abdominal wall. MRI plays a crucial role in determining a diagnosis or narrowing the differential diagnosis, thus facilitating effective management.
Impact of COVID-19 pandemic on control of bronchial asthma in children attending the asthma clinic in a tertiary care centre in Kerala
Authors: Varghese Meenu Anna , Sreelatha P R , Peter Anu Marie
Published: December 2023

BACKGROUND:

COVID-19 pandemic led to widespread change in the life of people across the globe, including children, with far-reaching consequences. When control of disease is considered among children with asthma, a positive impact is to be expected. This study aimed to assess the impact of the COVID-19 pandemic on disease control among children with asthma.

OBJECTIVES:

The main objectives are (1) to compare the level of asthma control pre-COVID versus during the COVID pandemic in terms of exacerbations and short-acting beta agonist (SABA) usage and (2) to compare the use of inhaled corticosteroids (ICS) pre-COVID versus during the COVID pandemic.

MATERIALS AND METHODS:

Hospital-based study was conducted among children aged 5–15 years attending the asthma clinic of Government TD Medical College, Alappuzha, during the period May 2021–January 2022. Asthma control in terms of SABA usage, emergency visits, hospitalizations, and ICS usage was compared pre-COVID (before March 2020) to Complete lockdown (March 2020–May 2020), phased reopening (June 2020–May 2021) and after the lifting of major restrictions (June 2021–January 2022). Statistical analysis was done using IBM SPSS Statistics v.26.

RESULTS:

In total, 139 children were included in the study. A decrease was observed in the number of children requiring SABA as reliever therapy, with 18%, 25.9%, and 33.1% not requiring SABA during the complete lockdown, during phased reopening, and after the lifting of major restrictions, respectively, when compared to pre-COVID. A statistically significant decrease in hospitalizations and visits to the emergency department due to asthma exacerbations were also observed during various phases of the pandemic. ICS was stopped in 15.1%, 30.2%, and 35.3% of the study subjects during various phases of the pandemic without further exacerbations.

CONCLUSION:

There was a significant impact on asthma control during the pandemic, which was sustained during various phases of lifting restrictions.
Effectiveness of probiotics in autism spectrum disorder: A case comparison pilot study
Authors: Jagadeesh Ananthan , Little Flower Anchu Chellappan , Sasikumar Anuja , Asokan Aparnna Beena , Swamy Mathan , Binod Deepa , Chowdhury Sreetama , Gautam Amrita , Sivaram Remadevi , Nair MKC
Published: December 2023

INTRODUCTION:

Children with autism have a higher prevalence of gastrointestinal problems than typically developing children. Global research shows inconsistent results in efficacy of probiotics in decreasing gastrointestinal and behavioral symptoms in Autism. This study is a pilot study conducted in Kerala, India, to evaluate the effectiveness of probiotics in autistic children.

MATERIALS AND METHODS:

The present study is a hospital-based case–comparison study in autistic children in the age range of 2–6 years. The study arm received probiotics sachets for 2 months, and the change in gastrointestinal and behavioral symptoms in the study and control arm was compared post-intervention.

RESULTS:

There is a significant improvement in gastrointestinal and behavioral symptoms post-intervention in the study arm. However, on comparing the study and comparison arm, statistically significant improvement was observed only in gastrointestinal domain (P = 0.011).

CONCLUSION:

The present study establishes the need of large-scale, double-blinded, randomized controlled trials to come to a consensus agreement regarding effectiveness of probiotics in autism.
Association of screen time and physical activity with central obesity among adolescent school children in Kerala
Authors: Puthussery Tina P , Unnikrishnan Deepa T
Published: December 2023

CONTEXT:

Adolescents with increased sedentary behaviors can have an association with central adiposity and metabolic risk.

AIMS:

To estimate the prevalence of central obesity in adolescent school children in Kerala and to determine the association of excess screen time and inadequate physical activity with central obesity.

SETTINGS AND DESIGN:

Selected schools in Ernakulam District, a cross-sectional study.

METHODS AND MATERIALS:

Adolescents’ (n = 400; 14–18 years) weight, height, and waist circumference (WC) were measured. Sedentary behaviors [excess screen time (ST ≥ 2 h/day) and inadequate physical activity (moderate to vigorous physical activity < 1 h/day) ] were measured using a prevalidated instrument. The association between sedentary behaviors and central adiposity indicators (WC > 90th percentile, waist-to-height ratio (WHtR) > 0.5, and WC > 70th percentile are taken as the cutoff for metabolic risk) was analyzed using Pearson Chi-square test.

RESULTS:

The prevalence of central obesity was 3.5% with WC > 90th percentile and 19.8% with WHtR > 0.5 and that of adolescents with metabolic risk was 10.5%. Excess screen time and inadequate physical activity were found in 64.5% and 61.3% of the total population respectively. However, no significant association was found. But it was observed that the majority of centrally obese children (WC > 90th percentile) and those with metabolic risk were having some physical activity and were not sedentary (100% and 92.9%, respectively) which was statistically significant.

CONCLUSIONS:

Results indicate a high prevalence of central obesity and metabolic risk and incomplete awareness about the recommended physical activity guidelines, possible co-existence of other risk factors, and the need for integrated interventions that will reduce at-risk behaviors.
A pilot study of “adverse events following immunization” surveillance with COVID-19 vaccination among adolescents: A prospective observational study based on single-center experience from a tertiary care hospital
Authors: Pasi Rachna , Babu Thirunavukkarasu Arun , Kallidoss Vinoth Kumar
Published: December 2023

BACKGROUND:

COVID-19 vaccination was started on January 3, 2022, among children aged 15–-18 years with Covaxin vaccination. Subsequently, Corbevax was approved for age groups up to 12 years of age since March 16, 2022.

OBJECTIVES:

To know the incidence and spectrum of adverse effects following immunization (AEFI) for this newly approved COVID-19 vaccine for children.

DESIGN:

This was a prospective observational pilot study undertaken in a tertiary-level care hospital.

MATERIALS AND METHODS:

All children vaccinated at our tertiary care center in South India were enrolled after informed consent. AEFI at 30 min, up to 24 h, and 1–7 days postvaccination are noted. The causality assessment was done.

RESULTS:

A total of 36 participants were studied, out of which 24 received Covaxin and 12 received Corbevax. No immediate AEFI was noted with any vaccine. Up to 24 h, 22/36 (61%) AEFI noted where 12/24 (50%) with Covaxin and 10/12 (83.3%) with Corbevax. Postvaccination within 1–7 days, only 1 (2.8%) side effects were present with Covaxin. Fever was reported statistically more in the Corbevax vaccine (P = 0.03).

CONCLUSION:

Corbevax and Covaxin both are safer vaccines for children. None of the vaccines had any major side effects. Maximum AEFI noted were up to 24 h postvaccination.
Optimization of Carbon and Nitrogen Source to Enhance Antibacterial Activity from a Sponge-derived Bacillus tequilensis
Authors: Murniasih Tutik , Mardiana Nur Agustin , Untari Febriana , Triwibowo Joko , Bayu Asep
Published: December 2023

In our endeavor to find antibacterial from marine bacteria, we screened the microbiota from a Lithistid sponge, collected from Seribu Island, Jakarta. One of the promising strains was K 2.4.2. Identification of the strain using 16S rRNA Sanger sequencing resulted a sequence similarity of 100% to Bacillus tequilensis. Response surface methodology was applied to optimize the culture conditions for enhancing antibacterial activity of the strain. The optimization was carried out using Box-Behnken design experiment to determine the optimum carbon and nitrogen sources in order to produce maximum antibacterial activity. The optimum media with high antibacterial activity was marine broth with the addition of carbon and nitrogen concentration source of sucrose 2.15 % and peptone 1.08%, respectively. In addition, the optimum temperature was 31.18oC. The antibacterial activity response was predicted using a statistical model and compared to the activity in the experiment. The difference between the model and the laboratory experiment was less than 5% which showed a good accuracy. The results of this study once again showed that optimization method effectively reduced time, chemicals, and energy.
Geriatric Medicine in South Korea: A Stagnant Reality amidst an Aging Population
Authors: Ji Sunghwan , Jung Hee-Won , Baek Ji Yeon , Jang Il-Young , Lee Eunju
Published: December 2023

In the face of an ever-increasing wave of an aging population, this paper provides an update on the current status of geriatric medicine in Korea, comparing it with global initiatives and suggesting future directions. Older adults require a multifaceted approach, addressing not only comorbidity management but also unmet complex medical needs, nutrition, and exercise to prevent functional decline. In this regard, the World Health Organization's Integrated Care for Older People guidelines underscore the importance of patient-centered primary care in preventing a decline in intrinsic capacity. Despite these societal needs and the ongoing aging process, the healthcare system in Korea has yet to show significant movement or a shift toward geriatric medicine, further complicated by the absence of a primary care system. We further explore global efforts in establishing age-integrative patient-centered medical systems in Singapore, Australia, Canada, the United Kingdom, and Japan. Additionally, we review the unmet needs and social issues that Korean society is currently facing, and local efforts by both government and a private tertiary hospital in Korea. In conclusion, considering the current situation, we propose that the framework of geriatric medicine should form the foundation of the future healthcare system.
Increasing the stability of LiMn2O4 electrodes under high-current-density conditions via SoC control in an electrochemical lithium recovery system
Authors: Kim Eunhee , Kim Byunghyun , Lee Jaehan
Published: December 2023

For efficient lithium recovery, the electrochemical lithium recovery (ELR) process that uses LiMn2O4 (LMO) electrodes with selectivity for lithium ions, has been introduced. The electrochemical system is environmentally friendly and allows for the recovery of lithium at a high yield, but the issue of manganese dissolution in LMO electrodes, decreasing their stability, remains to be solved. Herein, we suggest a solution to the existing problem through a rapid lithium recovery method that also enhances the stability of LMO electrodes through the state-of-charge (SoC) control approach. The retained discharge capacity of the system with a high current density (0.4 A/g) remains at 99.2% at 60% SoC after 300 cycles. Compared to the results under full charge/discharge operation (44.2% after 300 cycles), the proposed method demonstrates the state-of-charge (SoC) control adjustments at high current density levels to enhance the recovery rate and stability of the electrode. Additionally, high lithium-ion selectivity with a similar recovery rate is maintained at a high current density under 60% SoC operation compared to 100% SoC in lithium recovery tests. These results indicate that the SoC control strategy can increase the efficiency of ELR by improving the stability of the electrode under high-rate operational conditions.
Analysis of influencing parameters and reactive substance for enrofloxacin degradation in a dielectric barrier discharge plasma/peroxydisulfate system
Authors: Song Shili , Wang Huijuan , Huang Yuyue , Ma Yixing
Published: December 2023

In this paper, the chemical and physical effects generated during the dielectric barrier discharge plasma (DBDP) process, including O3, H2O2, light, e*, etc., were utilized to activate the peroxydisulfate (PDS) to form SO4 −•. Then, the original reactive oxygen species (ROS), such as •OH, formed in the discharge system was combined to degrade the enrofloxacin (ENR) in water, and the corresponding influencing parameters and reactive substance in the DBDP/PDS system were analyzed. From the investigation, it was found that the neutral (pH =6.5) solution was more conducive to the ENR decomposition than the acidic and alkaline solution conditions. The presence of Fe2+ and Cu2+ in the reaction solution could hasten the ENR degradation, whereas the addition of Cl− and the HCO3 − in the solution had a negative effect. Analysis of the reactive species and quenching tests were carried out to explore the generation of H2O2, O3, •OH, and SO4 −• in the DBDP/PDS system and their effects on the ENR degradation. The UV-Vis and 3D fluorescence spectra analysis were applied to demonstrate the cooperative effects of the DBDP and the PDS. The TOC and COD removals of the ENR solutions in the DBDP and the DBDP/PDS systems were also compared. Based on the intermediates analysis of the ENR degradation, three possible pathways of ENR decomposition in the synergistic system have been inferred.
Kutsal Alanlar, Coğrafi İşaretler, Kültür ve İnanç Rotalarının İnanç Turizmi Açısından Değerlendirilmesi
Authors: CAM Oguz , AVCI Muharrem
Published: December 2023

Turizm, dünyada önemli bir hareketlilik sağlayan olayların bütünüdür. Turizmin pek fazla alt alanı mevcuttur. Bu alt alanlardan biri inanç turizmidir. İnanç turizmi uluslararası ve ulusal arenalarda büyük bir potansiyele sahip olmakta ve önem teşkil etmektedir. Bu bilgiler ışığında inanç turizmi kapsamında geleneksel derleme çeşidinde bir çalışma yapmak istenmiştir. Bu çalışmanın gerçekleştirilmesindeki amaç, kutsal alanların, coğrafi işaretlerin, kültür ve inanç rotalarının inanç turizmi açısından değerlendirilmesini sağlamaktır. Çünkü inanç turizmi çok geniş bir etki alanına sahiptir. Kutsal alanlar, coğrafi işaretler, kültür ve inanç rotaları da inanç turizmi kapsamında önemlidir. Sonuç olarak; kutsal alanlar, coğrafi işaretler, kültür ve inanç rotaları inanç turizmi kapsamında büyük potansiyel ve öneme sahip olmakta, psikolojik, sosyolojik, turistik, ekonomik, dini, inançsal, kültürel, tarihi, çevresel, mimari ve benzeri açılardan etkileşimler meydana getirmektedir.
HUBUNGAN POWER OTOT LENGAN TERHADAP KEMAMPUAN LEMPAR LEMBING
Authors: Ambia Fachrizal , Zahara Zahara , Ifwandi Ifwandi , Rinaldy Alfian
Published: December 2023

Lempar lembing merupakan kemampuan seseorang dalam menunjukkan atau melakukan gerak melempar yang mencerminkan tolak ukur objektif dari pegangan atau grip lembing, lari awalan, tahap berirama atau menyilang, kecepatan dan daya ledak otot lengan sangatlah berperan penting, tetapi gerakan lengan sangat luas. Dengan gerakan yang luas tersebut, Dengan demikian yang menjadi tujuan dalam penelitian ini yaitu kontribusi daya ledak otot lengan terhadap kemampuan lempar lembing, metode dalam penelitian ini menggukan metode pengukuran power lengan dan lempar lembing, berdasarkan penelitian yang dilakukan diperoleh hasil bahwasanya (1) terdapat hubungan yang positif dan signifikan antara power otot lengan dengan kemampuan  dalam lempar lembing sebesar (r= 0,69), Power otot Lengan memberikan hubungan  sebanyak 47,61% terhadap kemampuan lempar lembing. Power Otot lengan merupakan bagian tubuh yang sangat penting dalam mendukung keberhasilan aktivitas manusia, power merupakan salah satu kemampuan penting yang harus dimiliki oleh seorang atlet, terutama power lengan karena setiap gerakan yang dilakukan dalam olahraga lempar lembing membutuhkan power otot lengan yang baik juga didukung unsur-unsur lainnya.AbstractJavalin throwing is a person’s ability to demonstrate or carry out throwing movements that reflect objective benchmarks from the javelin’s grip, starting run, rhythmic or crossing stages, speed and explosive power of the arm muscles play an important role, the aim of this research is the contribution of arm muscle explosive power to javekin throwing ability. The method in this research uses methods for measuring arm power and javelin throwing. Based on the research carried out, the result show that (1) there is a relationship The positive and significant  relationship between arm muscle power and javelin throwing ability is (r= 0.69). Arm muscle power has a 47.67% relationship with javelin throwing ability. Arm muscle power Is a very important part of the body in supporting the success of human activities. Power is one of the important abilities that an athlete must have, especially arm power because every movement carried out in the sport of javelin throwing requires good arm muscle power which is also supported by the following elements other elements.
Neural Coding as a Statistical Testing Problem
Authors: Ost Guilherme , Reynaud-Bouret Patricia
Published: December 2023

We take the testing perspective to understand what the minimal discrimination
time between two stimuli is for different types of rate coding neurons. Our
main goal is to describe the testing abilities of two different encoding
systems: place cells and grid cells. In particular, we show, through the notion
of adaptation, that a fixed place cell system can have a minimum discrimination
time that decreases when the stimuli are further away. This could be a
considerable advantage for the place cell system that could complement the grid
cell system, which is able to discriminate stimuli that are much closer than
place cells.
THE ROLE OF THE LEADER IN THE PROCESS OF ORGANIZATIONAL CULTURE FORMATION AND MAIN CHALLENGES
Authors: Giorgobiani Maia , Dugladze Davit , Dzotsenidze Tinatin , Qajaia Tatia
Published: December 2023

Maia Giorgobiani

E-mail: maia.giorgobiani@tsu.ge

Associate Professor, Ivane Javakhishvili Tbilisi State University

Tbilisi, Georgia

https://orcid.org/0000-0001-9328-7239

 

Davit Dugladze

E-mail: dugladzedavit@gmail.com 

Associate Professor, Georgian State Teaching University of Physical Education and Sport

Tbilisi, Georgia

https://orcid.org/0000-0003-0722-0092

 

Tinatin Dzotsenidze

E-mail: tinatindzotsenidze5@gmail.com

PhD student, Ivane Javakhishvili Tbilisi State University

Tbilisi, Georgia

https://orcid.org/0000-0001-8747-0782

 

Tatia Qajaia

E-mail: Tkaj2011@agruni.edu.ge

PhD student, Sokhumi State University

Tbilisi, Georgia

https://orcid.org/0009-0005-7210-345X

 

Abstract. Organizational culture has a great impact on employee behavior and productivity. A healthy organizational culture is directly proportional to employee engagement and motivation. It should be noted that leaders themselves have an important role in forming the appropriate organizational culture. Organizational culture is the object of research for many scientists. Any culture shapes appropriate behavior in individuals and groups. For each member of the organization, it is important to encourage them with salary. The creation of an organizational climate is often related to a fair incentive policy in the organization. Satisfaction with the supervisor depends on many factors, the management style chosen by him is important, as well as the characteristics of involvement in the decision process, motivational policy, and the environment created by the supervisor. Several studies have shown that job satisfaction is determined by the relationship style of the employee and the supervisor. Therefore, the management of the organization needs to develop a program to increase activities and encourage not only job satisfaction but also good working relationships between superiors and subordinates. In the presented work, we focused on these and other important issues. The purpose of the research we presented is to highlight the leader's role in forming the desired organizational climate. Respondents employed in three public structures of economic profile took part in the presented research. The results obtained during the research process were processed using the SPSS statistical software package. Based on the obtained results, appropriate conclusions and recommendations were developed.
Optimizacija organizacije subnacionalne razine Republike Hrvatske
Authors: Žmegač Davor
Published: December 2023

U radu se istražuju i analiziraju pokazatelji organizacije subnacionalne razine Hrvatske i Europske unije. Cilj rada je temeljem provedene komparativne analize utvrditi aktualne trendove EU-a u organizaciji subnacionalne razine te sukladno rezultatima dati preporuke kao smjernice za institucionalne reforme na nacionalnoj razini. Naglasak u istraživanju i analizi stavljen je na fragmentaciju regionalne razine država članica EU-a u usporedbi s Hrvatskom te trendove u optimizaciji i regionalnoj kompetitivnosti subnacionalne razine na području EU-a. U radu se naglašava i važnost institucija u provođenju aktivnosti na unaprjeđenju i razvoju regionalne i lokalne razine, kao važne osnovice za društveni i ekonomski razvoj svakog nacionalnog sustava. Istraživanje je smješteno unutar teorijskog okvira regionalne ekonomike. Metodološki, temeljem cilja istraživanja najprije su istraženi makro pokazatelji Hrvatske i EU-a u dijelu fragmentacije regionalne razine, nakon čega je izvedena usporedna analiza organizacije Hrvatske i sličnih država EU-a prema kriteriju broja stanovnika, a u zadnjem dijelu dan je naglasak na važnost institucija u upravljanju i ekonomskim politikama rasta i razvoja te kompetitivnosti regionalne i lokalne razine. Koriste se zadnji javno dostupni podaci vezani uz odabrane pokazatelje regionalne ekonomike Hrvatske i EU-a te odgovarajući podaci OECD-a. Usporedbom s državama članicama EU-27 te posebno s odabranim državama koje imaju sličnosti s Hrvatskom (po kriteriju broja stanovnika), rezultati istraživanja ukazuju da je fragmentacija organizacije u Hrvatskoj značajnija nego u usporednim državama. Isto tako, pokazuje se i da je kompetitivnost na razini NUTS 2 regija oko 20% niža od usporedivih regija EU-27, pri čemu je osobito izraženo da je institucionalni okvir jedan od temeljnih problema u izraženom zaostajanju u kompetitivnosti subnacionalne razine Hrvatske. Rezultati istraživanja i izvedene preporuke dovode do zaključnih razmatranja, koja utvrđuju moguće smjernice za institucionalne reforme i odgovarajuće politike regionalne ekonomike Republike Hrvatske, što je ujedno i glavni doprinos ovog rada.
Utjecaj identiteta na formiranje stavova raseljenih osoba iz Ukrajine
Authors: Carević Matija , Polović Jadranka
Published: December 2023

U radu se prikazuje šira slika polarizacije ukrajinskog društva i uloge regionalnog identiteta na formiranje stavova raseljenih osoba iz Ukrajine u Republici Hrvatskoj o proruskim i prozapadnim narativnim linijama. Naime, rat u Ukrajini ubrzao je proces reartikulacije ukrajinskog nacionalnog identiteta koji je započeo početkom stoljeća uslijed pogoršanja odnosa između Zapada i Rusije. U radu se upotrebljavaju metode deskriptivne statistike, dok se u obradi hipoteza upotrebljava Mann-Whitney U test. Statističkom analizom rezultata ankete provedene među raseljenim osobama iz Ukrajine u Republici Hrvatskoj uočena je razlika u stavovima ispitanika iz istočnog i zapadnog dijela Ukrajine, ali i općenito veće slaganje s prozapadnim narativnim linijama.
Održivi razvoj i brza moda generacije Y
Authors: Markuz Ana , Ban Doroteja , Pavličić Radmila
Published: December 2023

Cilj je ovog rada istražiti pojave i procese koji su doveli do fenomena „brze mode” te negativno utjecali na okoliš i ljude. U teorijskom dijelu rada objašnjeni su koncepti „brze mode” i generacije Y. Postavljena su sljedeća istraživačka pitanja: može li se u dogledno vrijeme usporiti trend rasta brze mode i hoće li generacija Y preobraziti modu u održivu. U istraživanju je sudjelovalo 200 ispitanika rođenih između 1977. i 1996., odnosno pripadnici generacije Y, a istraživanje je provedeno između 3. i 17. ožujka 2022. anketnim upitnikom koji je diseminiran na internetu. Postavljene su sljedeće hipoteze: „Generacija Y ima svijest o održivosti mode.” i „Generacija Y neće modu učiniti održivom.” Nakon provedene statističke obrade podataka i testiranja normalnosti razdiobe odgovora na anketna pitanja korištenjem statističke metode hikvadrat-testa izvodili su se zaključci o valjanosti hipoteza. Obje su hipoteze potvrđene. Uz zaključna razmatranja u radu se predstavljaju i ograničenja istraživanja i praktične implikacije rezultata istraživanja.
The influence of extended motor mode on the mental performance of children aged 5–6 years
Authors:   Mary Poppins LLC, Kisel M. A. , Kisel S. A. ,   Grodno State University named after Yanka Kupala, Grodno
Published: December 2023

The mental performance of children aged 5–6 years old, recorded in the conditions of regular and extended physical activity regimes of a preschool educational institution, corresponded to the characteristics of the age development of preschoolers in the senior group of kindergarten. An expanded regime of physical activity, including additional rhythmic gymnastics classes and exercises in the pool, contributes to a more pronounced increase in the speed and stability of mental work of children 5–6 years old in daily and weekly dynamics in comparison with the traditional organization of physical activity.
Panticapaeum torso: an approach to stylistic interpretation
Authors: Бузунова И.В.
Published: December 2023

Важнейшей задачей антиковедения является уточнение или определение стилистической, иконографической, хронологической атрибуции античного произведения с помощью специальных методик, технико-технологических исследований, составляющих инструментарий современного ученого. Наличие археологического сопровождения и провенанса памятника значительно облегчают задачу, но в случае с классическими музейными артефактами из частных собраний, не обладающими документально подтвержденным происхождением, возникают проблемы с интерпретацией антика. Тогда в исследовании актуализируются теоретические приемы методологии, созданные представителями немецкой школы XIX – начала XX века позитивистского направления. Антиковеды последующего поколения развили и усовершенствовали предшествующие теории, создав новые, в основе которых использовали уже утвердившиеся принципы формально-стилистического, сравнительно-стилистического анализа, модифицировали историко-культурологический контекст, интерпретацию. Таким образом, сформировался комплексный мультидисциплинарный подход к изучению предмета с применением средств исторической, археологической, филологической, культурологической наук. Способы современного исследования памятника с неясной историей, подобного эрмитажному торсу из Пантикапея, уточняют атрибуцию, расширяют возможности многогранного прочтения артефакта и фиксации в нем художественных особенностей той или иной школы. В результате древнее произведение становится частью античного наследия и занимает свое место в классификации древнегреческой скульптуры.

One of the most important aims of Ancient Studies is stylistic, iconographic and chronological identification of art item through methods of style-comparative research and technical-technological analysis. Archaeological description and provenance make it easier but museum items often lack the latter which brings much trouble to a scholar. If so, the scholar has to use all the theoretical methods provided to us by the German Classical scholarship of 19th and early 20th century. Scholars of the next generation cultivated and improved those methods on basis of the formal analysis and style-comparative analysis with regard to historical and cultural context. Their work resulted in interdisciplinary approach to art research which includes History, Archaeology, Philology, and Culturology. Modern methods of research allow us to specify the identification of art items that lack provenance like Panticapaeum torso from Hermitage. The methods rest on discovery of the specific features that help to reveal the item affiliation to some of Ancient art schools. As a result, the art item finds its place in the classification of Ancient sculpture.
Religious art in the collection of the Ryazan State Regional Art Museum named after I.P. Pozhalostin
Authors: Зайцева М.В.
Published: December 2023

Статья посвящена религиозному искусству конца XV – начала XXвека. Предметом исследования является иконопись, полихромная деревянная скульптура и медное литье, происходящие из храмов Рязанской области. Основным материалом выступила коллекция Рязанского областного художественного музея им. И.П. Пожалостина. В качестве вспомогательного материала привлечены произведения из собраний российских музеев и частных коллекций. Исследовательский интерес вызывает стилистическое своеобразие памятников из состава коллекции, а также выбор иконографий, отражающих основные тенденции развития русского религиозного искусства. В статье представлен обзор наиболее значимых предметов коллекции. В исследовании использовались сравнительно-стилистический и сравнительно-исторический методы.

The article focuses on the religious art of the late fifteenth to early twentieth centuries. It delves into the iconography, wooden polychrome sculptures and copper castings that originated from the cathedrals of the Ryazan region. Through the research, the author examines the collection of the Ryazan State Regional Art Museum named after I.P. Pozhalostin, as well as works from other Russian museums and private collections. The main focus of the research is on the stylistic originality of the collection's monuments and the selection of iconography that reflects the significant trends in the development of Russian religious art. The article provides an overview of the collection's most valuable pieces. The author employs comparative-historical and comparative-stylistic methods.