bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation and Properties of Cross-Linked Starch Nanocrystals/Polylactic Acid Nanocomposites
Authors: Yin Zuodong , Zeng Jiliang , Wang Cai , Pan Zelin
Published: March 2015

Cross-linked starch nanocrystals (CStN)/polylactic acid (PLA) nanocomposites were prepared by blending CStN and PLA, wherein CStN were homogeneously dispersed in the nanocomposites. The structure and morphology of the nanocomposites were studied through FTIR, XRD, and SEM. The results of mechanical test showed that the strength and toughness of the nanocomposites could be improved when the additive amount of hydrophobic CStN was 3% (weight ratio). Meanwhile, the microstructures of tensile fracture surface showed that CStN were uniformly dispersed in PLA matrix, and the tensile fracture surface was presented as ductile fracture. Moreover, water vapor permeability experiments illustrated that the addition of CStN reduced the water vapor permeability of PLA nanocomposites, so CStN have some resistance to water vapor. Those above indicated that CStN have functions of reinforcement and toughness in PLA matrix; therefore, they are expected to be used as functional additives in polymer matrix such as PLA, polycaprolactone (PCL), and polybutylene succinate (PBS).
Study on Hot Deformation Behavior of 7085 Aluminum Alloy during Backward Extrusion Process
Authors: Mei R. B. , Du Y. X. , Bao L. , Zhang X. Y. , Zhang B. , Zhou Z. J.
Published: March 2015

Compression test was carried out and the true stress-strain curves were obtained from the hot compression of 7085 alloy. A numerical simulation on the deformation behavior of 7085 aluminum alloy during the backward extrusion was also performed by finite element method. The results show that dynamic recrystallization occurs in the hot compression of 7085 alloy and the peak stress reaches higher values as the strain rate increases and deformation temperature decreases. The backward extrusion processes include contact deformation, initial deformation, and steady deformation. Severe plastic deformation of shear and compression occurs when the metal flowed into the channel between fillet of punch and wall of die so that the grain size can be refined by backward extrusion. The deformation in the region of top of wall is too small to meet the mechanical properties of requirements and the metal usually needs to be trimmed. The experiments with the same parameters as simulation had been carried out and the experimental cup after extrusion has better quality.
Experimenter Effects on Pain Reporting in Women Vary across the Menstrual Cycle
Authors: Vigil Jacob M. , DiDomenico Jared , Strenth Chance , Coulombe Patrick , Kruger Eric , Mueller Andrea A. , Guevara Beltran Diego , Adams Ian
Published: March 2015

Background. Separate lines of research have shown that menstrual cycling and contextual factors such as the gender of research personnel influence experimental pain reporting.Objectives. This study examines how brief, procedural interactions with female and male experimenters can affect experimentally reported pain (cold pressor task, CPT) across the menstrual cycle.Methods. Based on the menstrual calendars 94 naturally cycling women and 38 women using hormonal contraceptives (Mage=19.83,  SD=3.09) were assigned to low and high fertility groups. This assignment was based on estimates of their probability of conception given their current cycle day. Experimenters (12 males, 7 females) engaged in minimal procedural interactions with participants before the CPT was performed in solitude.Results. Naturally cycling women in the high fertility group showed significantly higher pain tolerance (81 sec,d=.79) following interactions with a male but not a female experimenter. Differences were not found for women in the low fertility or contraceptive groups.Discussion. The findings illustrate that menstrual functioning moderates the effect that experimenter gender has on pain reporting in women.Conclusion. These findings have implications for standardizing pain measurement protocols and understanding how basic biopsychosocial mechanisms (e.g., person-perception systems) can modulate pain experiences.
The Evolutionary History of Daphniidα-Carbonic Anhydrase within Animalia
Authors: Culver Billy W. , Morton Philip K.
Published: March 2015

Understanding the mechanisms that drive acid-base regulation in organisms is important, especially for organisms in aquatic habitats that experience rapidly fluctuating pH conditions. Previous studies have shown that carbonic anhydrases (CAs), a family of zinc metalloenzymes, are responsible for acid-base regulation in many organisms. Through the use of phylogenetic tools, this present study attempts to elucidate the evolutionary history of theα-CA superfamily, with particular interest in the emerging model aquatic organismDaphnia pulex. We provide one of the most extensive phylogenies of the evolution ofα-CAs, with the inclusion of 261 amino acid sequences across taxa ranging from Cnidarians toHomo sapiens. While the phylogeny supports most of our previous understanding on the relationship of howα-CAs have evolved, we find that, contrary to expectations, amino acid conservation with bacterialα-CAs supports the supposition that extracellularα-CAs are the ancestral state of animalα-CAs. Furthermore, we show that two cytosolic and one GPI-anchoredα-CA inDaphniagenus have homologs in sister taxa that are possible candidate genes to study for acid-base regulation. In addition, we provide further support for previous findings of a high rate of gene duplication withinDaphniagenus, as compared with other organisms.
Nutrient Induced Type 2 and Chemical Induced Type 1 Experimental Diabetes Differently Modulate Gastric GLP-1 Receptor Expression
Authors: Bloch Olga , Broide Efrat , Ben-Yehudah Gilad , Cantrell Dror , Shirin Haim , Rapoport Micha J.
Published: March 2015

T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2DM and T1DM were induced inPsammomys obesus(PO) by high-energy (HE) diet and by streptozotocin (STZ) in Sprague Dawly (SD) rats, respectively. GLP-1R expression was determined in glandular stomach by RT PCR and immunohistomorphological analysis. The mRNA expression and cellular association of the GLP-1R in principal glands were similar in control PO and SD rats. However, nutrient and chemical induced diabetes resulted in opposite alterations of glandular GLP-1R expression. Diabetic PO demonstrated increased GLP-1R mRNA expression, intensity of cellular GLP-1R immunostaining, and frequency of GLP-1R positive cells in the neck area of principal glands compared with controls. In contrast, SD diabetic rats demonstrated decreased GLP-1 mRNA, cellular GLP-1R immunoreactivity, and frequency of GLP-1R immunoreactive cells in the neck area compared with controls. In conclusion, nutrient and chemical induced experimental diabetes result in distinct opposite alterations of GLP-1R expression in glandular stomach. These results suggest that induced T1DM and T2DM may differently modulate GLP-1R system in enteropancreatic axis.
Exocrine Pancreatic Insufficiency in Diabetic Patients: Prevalence, Mechanisms, and Treatment
Authors: Piciucchi Matteo , Capurso Gabriele , Archibugi Livia , Delle Fave Martina Maria , Capasso Marina , Delle Fave Gianfranco
Published: March 2015

Pancreas is a doubled-entity organ, with both an exocrine and an endocrine component, reciprocally interacting in a composed system whose function is relevant for digestion, absorption, and homeostasis of nutrients. Thus, it is not surprising that disorders of the exocrine pancreas also affect the endocrine system and vice versa. It is well-known that patients with chronic pancreatitis develop a peculiar form of diabetes (type III), caused by destruction and fibrotic injury of islet cells. However, less is known on the influence of diabetes on pancreatic exocrine function. Pancreatic exocrine insufficiency (PEI) has been reported to be common in diabetics, with a prevalence widely ranging, in different studies, in both type I (25–74%) and type II (28–54%) diabetes. A long disease duration, high insulin requirement, and poor glycemic control seem to be risk factors for PEI occurrence. The impact of pancreatic exocrine replacement therapy on glycemic, insulin, and incretins profiles has not been fully elucidated. The present paper is aimed at reviewing published studies investigating the prevalence of PEI in diabetic patients and factors associated with its occurrence.
Binary Matrix Shuffling Filter for Feature Selection in Neuronal Morphology Classification
Authors: Sun Congwei , Dai Zhijun , Zhang Hongyan , Li Lanzhi , Yuan Zheming
Published: March 2015

A prerequisite to understand neuronal function and characteristic is to classify neuron correctly. The existing classification techniques are usually based on structural characteristic and employ principal component analysis to reduce feature dimension. In this work, we dedicate to classify neurons based on neuronal morphology. A new feature selection method named binary matrix shuffling filter was used in neuronal morphology classification. This method, coupled with support vector machine for implementation, usually selects a small amount of features for easy interpretation. The reserved features are used to build classification models with support vector classification and another two commonly used classifiers. Compared with referred feature selection methods, the binary matrix shuffling filter showed optimal performance and exhibited broad generalization ability in five random replications of neuron datasets. Besides, the binary matrix shuffling filter was able to distinguish each neuron type from other types correctly; for each neuron type, private features were also obtained.
Spectroscopic Analysis of Au-Cu Alloy Nanoparticles of Various Compositions Synthesized by a Chemical Reduction Method
Authors: Latif-ur-Rahman  , Shah Afzal , Qureshi Rumana , Khan Sher Bahadar , Asiri Abdullah M. , Shah Anwar-ul-Haq Ali , Ishaq Muhammad , Khan Mohammad Saleem , Lunsford Suzanne Kay , Zia Muhammad Abid
Published: March 2015

Au-Cu alloy nanoparticles were synthesized by a chemical reduction method. Five samples having different compositions of Au and Cu (Au-Cu 3 : 1, Au-Cu 2 : 1, Au-Cu 1 : 1, Au-Cu 1 : 2, and Au-Cu 1 : 3) were prepared. The newly synthesized nanoparticles were characterized by electronic absorption, fluorescence, and X-ray diffraction spectroscopy (XRD). These alloy nanoparticles were also analyzed by SEM and TEM. The particle size was determined by SEM and TEM and calculated by Debye Scherrer’s equation as well. The results revealed that the average diameter of nanoparticles gets lowered from 80 to 65 nm as the amount of Cu is increased in alloy nanoparticles. Some physical properties were found to change with change in molar composition of Au and Cu. Most of the properties showed optimum values for Au-Cu alloy nanoparticles of 1 : 3. Cu in Au-Cu alloy caused decrease in the intensity of the emission peak and acted as a quencher. The fluorescence data was utilized for the evaluation of number of binding sites, total number of atoms in alloy nanoparticle, binding constant, and free energy of binding while morphology was deduced from SEM and TEM.
Prediction Technology of Power Transmission and Transformation Project Cost Based on the Decomposition-Integration
Authors: Lu Yan , Niu Dongxiao , Qiu Jinpeng , Liu Weidong
Published: March 2015

Through the analysis of power transmission and transformation project cost, total cost can be decomposed into construction cost, equipment purchase cost, installation cost, and other costs. This paper proposes a decomposition-integration cost prediction model taking a substation project as an example by fully considering the cost characteristics. In decomposition module, the total cost is decomposed into four expenses. In prediction module, different forecasting models are selected to forecast different expense. In integrated module, choose different integration methods to get the predicting results of total cost. The empirical results show that decomposition-integration prediction algorithm has good effect which can effectively predict the cost of power transmission and transformation project and has practical application and popularization value.
Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and Cirrhosis
Authors: Karidis Nikolaos P. , Delladetsima Ioanna , Theocharis Stamatios
Published: March 2015

Chronic hepatitis C virus (HCV) infection may eventually lead to progressive liver fibrosis and cirrhosis through a complex, multistep process involving hepatocyte death and regeneration. Despite common pathogenetic pathways present in all forms of liver cirrhosis irrespective of etiology, hepatocyte turnover and related molecular events in HCV-induced cirrhosis are increasingly being distinguished from even “similar” causes, such as hepatitis B virus- (HBV-) related cirrhosis. New insights in HCV-induced hepatocellular injury, differential gene expression, and regenerative pathways have recently revealed a different pattern of progression to irreversible parenchymal liver damage. A shift to the significant role of the host immune response rather than the direct effect of HCV on hepatocytes and the imbalance between antiapoptotic and proapoptotic signals have been investigated in several studies but need to be further elucidated. The present review aims to comprehensively summarize the current evidence on HCV-induced hepatocellular turnover with a view to outline the significant trends of ongoing research.
A Mac Protocol Implementation for Wireless Sensor Network
Authors: Bhar Jamila
Published: March 2015

IEEE 802.15.4 is an important standard for Low Rate Wireless Personal Area Network (LRWPAN). The IEEE 802.15.4 presents a flexible MAC protocol that provides good efficiency for data transmission by adapting its parameters according to characteristics of different applications. In this research work, some restrictions of this standard are explained and an improvement of traffic efficiency by optimizing MAC layer is proposed. Implementation details for several blocks of communication system are carefully modeled. The protocol implementation is done using VHDL language. The analysis gives a full understanding of the behavior of the MAC protocol with regard to backoff delay, data loss probability, congestion probability, slot effectiveness, and traffic distribution for terminals. Two ideas are proposed and tested to improve efficiency of CSMA/CA mechanism for IEEE 802.15.4 MAC Layer. Primarily, we dynamically adjust the backoff exponent (BE) according to queue level of each node. Secondly, we vary the number of consecutive clear channel assessment (CCA) for packet transmission. We demonstrate also that slot compensation provided by the enhanced MAC protocol can greatly avoid unused slots. The results show the significant improvements expected by our approach among the IEEE 802.15.4 MAC standards. Synthesis results show also hardware performances of our proposed architecture.
Foulant Characteristics Comparison in Recycling Cooling Water System Makeup by Municipal Reclaimed Water and Surface Water in Power Plant
Authors: Ping Xu , Jing Wang , Yajun Zhang , Jie Wang , Shuai Si
Published: March 2015

Due to water shortage, municipal reclaimed water rather than surface water was replenished into recycling cooling water system in power plants in some cities in China. In order to understand the effects of the measure on carbon steel corrosion, characteristics of two kinds of foulant produced in different systems were studied in the paper. Differences between municipal reclaimed water and surface water were analyzed firstly. Then, the weight and the morphology of two kinds of foulant were compared. Moreover, other characteristics including the total number of bacteria, sulfate reducing bacteria, iron bacteria, extracellular polymeric substance (EPS), protein (PN), and polysaccharide (PS) in foulant were analyzed. Based on results, it could be concluded that microbial and corrosive risk would be increased when the system replenished by municipal reclaimed water instead of surface water.
Development of a Rapid and Simple Method for Detection of Protein Contaminants in Carmine
Authors: Nakayama Norihisa , Ohtsu Yutaka , Maezawa-Kase Daisuke , Sano Ken-Ichi
Published: March 2015

Protein contaminants in carmine can cause dyspnea and anaphylactic reactions in users and consumers of products containing this pigment. The method generally used for detection of proteins in carmine has low reproducibility and is time-consuming. In this study, a rapid, simple, and highly reproducible method was developed for the detection of protein contaminants in carmine. This method incorporates acidic protein denaturation conditions and ultrafiltration. To prevent protein aggregation, sodium dodecyl sulfate containing gel electrophoresis running buffer was used for dispersing the carmine before filtration. An ultrafiltration device was used to separate the protein contaminants from carminic acid in the carmine solution. Two ultrafiltration devices were compared, and a cylindrical device containing a modified polyethersulfone membrane gave the best results. The method had high reproducibility.
Psychiatric Assessment and Screening for the Elderly in Primary Care: Design, Implementation, and Preliminary Results
Authors: Abrams Robert C. , Boné Blanca , Reid M. Cary , Adelman Ronald D. , Breckman Risa , Goralewicz Ronald , Palombo Marlena , Stern Amy , Shengelia Rouzi , Teresi Jeanne
Published: March 2015

Introduction. We describe the design and implementation of a psychiatric collaborative care model in a university-based geriatric primary care practice. Initial results of screening for anxiety and depression are reported. Methods and Materials. Screens for anxiety and depression were administered to practice patients. A mental health team, consisting of a psychiatrist, mental health nurse practitioner, and social worker, identified patients who on review of screening and chart data warranted evaluation or treatment. Referrals for mental health interventions were directed to members of the mental health team, primary care physicians at the practice, or community providers. Results. Subjects (N=1505) comprised 38.2% of the 3940 unique patients seen at the practice during the 4-year study period. 37.1% (N=555) screened positive for depression, 26.9% (N=405) for anxiety, and 322 (21.4%) screened positive for both. Any positive score was associated with age (P<0.033), female gender (P<0.006), and a nonsignificant trend toward living alone (P<0.095). 8.87% had suicidal thoughts. Conclusions. Screening captured the most affectively symptomatic patients, including those with suicidal ideation, for intervention. The partnering of mental health professionals and primary care physicians offers a workable model for addressing the scarcity of expertise in geriatric psychiatry.
Influence of Simvastatin-Loaded Implants on Osseointegration in an Ovariectomized Animal Model
Authors: Fang Wen , Zhao Shifang , He Fuming , Liu Li , Yang Guoli
Published: March 2015

The success of bone implants in the presence of osteoporosis is limited by lack of osseointegration between the implant and the natural bone. This study applied an electrochemical process to deposit simvastatin-nanohydroxyapatite (HA) coatings on porous implant surfaces and investigated the effects of these simvastatin-HA coatings on implant surfaces in an animal model of osteoporosis. In this study, simvastatin-HA coated implants were inserted into the tibia of osteoporotic rats. After 2, 4, and 12 weeks, tissue was retrieved for histomorphometric evaluation. The results indicated that the simvastatin-HA coatings increased bone-implant contact and new bone formation around implant surfaces. In conclusion, implants loaded with simvastatin by an electrochemical process improved implant osseointegration in osteoporotic rats. Furthermore, the increased concentration of simvastatin could affect the osseointegration, but the dose-effects also need further investigation.
Antibacterial Activity and Cytocompatibility of PLGA/CuO Hybrid Nanofiber Scaffolds Prepared by Electrospinning
Authors: Haider Adnan , Kwak Sanghwa , Gupta Kailash Chandra , Kang Inn-Kyu
Published: March 2015

The PLGA/CuO hybrid nanofibers scaffolds were prepared via electrospinning technique. The presence of CuO in the PLGA scaffolds was confirmed by transmission electron microscope (TEM) and X‐ray photoelectron spectroscopy (XPS). The scaffolds were subjected to various antibacterial and cytobiocompatibility tests. The results not only showed excellent adhesion, proliferation, and viability (live/dead staining) for fibroblastic cells but also revealed that PLGA/CuO hybrid nanofiber scaffolds inhibited both Gram‐positive and Gram‐negative bacterial growth. The mechanism of the antibacterial activity was concluded to be based on the CuO nanoparticles and Cu++ ions release. It is, therefore, evaluated that PLGA/CuO hybrid nanofiber scaffolds can be a useful candidate for wound dressing.
Emotional Intelligence Components in Alcohol Dependent and Mentally Healthy Individuals
Authors: Mohagheghi Arash , Amiri Shahrokh , Mousavi Rizi Seyedreza , Safikhanlou Salman
Published: March 2015

Objective. Emotional intelligence might play an important role in the onset and persistence of different psychopathologies. This study investigated the relationship between emotional intelligence and alcohol dependence. Methods. In this case‐control study, participants included alcohol dependent individuals and mentally healthy inpatients. Each group consisted of 40 individuals (male/female: 1). The diagnosis was based on the criteria of the DSM‐IV‐TR using the Structured Clinical Interview for DSM‐IV (SCID‐IV). All the participants completed Bar‐On emotional intelligence test. Results. 20 males and 20 females were included in each group. Mean age of alcohol dependent participants and controls was 31.28 ± 7.82 and 34.93 ± 9.83 years in that order. The analyses showed that the alcohol dependent individuals had a significant difference compared with the control group and received lower scores in empathy, responsibility, impulse control, self‐esteem, optimism, emotional consciousness, stress tolerance, autonomy, problem‐solving, and total score of emotional intelligence components. Conclusion. Patients with alcohol dependence have deficits in components of emotional intelligence. Identifying and targeted training of the individuals with lower scores in components of emotional intelligence may be effective in prevention of alcohol dependence.
Adipose Tissue-Derived Mesenchymal Stem Cells Exert In Vitro Immunomodulatory and Beta Cell Protective Functions in Streptozotocin-Induced Diabetic Mice Model
Authors: Rahavi Hossein , Hashemi Seyed Mahmoud , Soleimani Masoud , Mohammadi Jamal , Tajik Nader
Published: March 2015

Regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) might be applied for type 1 diabetes mellitus (T1DM) treatment. Thus, we proposed in vitro assessment of adipose tissue-derived MSCs (AT-MSCs) immunomodulation on autoimmune response along with beta cell protection in streptozotocin- (STZ-) induced diabetic C57BL/6 mice model. MSCs were extracted from abdominal adipose tissue of normal mice and cultured to proliferate. Diabetic mice were prepared by administration of multiple low-doses of streptozotocin. Pancreatic islets were isolated from normal mice and splenocytes prepared from normal and diabetic mice. Proliferation, cytokine production, and insulin secretion assays were performed in coculture experiments. AT-MSCs inhibited splenocytes proliferative response to specific (islet lysate) and nonspecific (PHA) triggers in a dose-dependent manner (P<0.05). Decreased production of proinflammatory cytokines, such as IFN-γ, IL-2, and IL-17, and increased secretion of regulatory cytokines such as TGF-β, IL-4, IL-10, and IL-13 by stimulated splenocytes were also shown in response to islet lysate or PHA stimulants (P<0.05). Finally, we demonstrated that AT-MSCs could effectively sustain viability as well as insulin secretion potential of pancreatic islets in the presence of reactive splenocytes (P<0.05). In conclusion, it seems that MSCs may provide a new horizon for T1DM cell therapy and islet transplantation in the future.
Idiopathic Generalized Epilepsy and Hypokalemic Periodic Paralysis in a Family of South Indian Descent
Authors: Subramanian Muthiah , Senthil N. , Sujatha S.
Published: March 2015

Inherited channelopathies are a heterogeneous group of disorders resulting from dysfunction of ion channels in cellular membranes. They may manifest as diseases affecting skeletal muscle contraction, the conduction system of the heart, nervous system function, and vision syndromes. We describe a family of South Indian descent with hypokalemic periodic paralysis in which four members also have idiopathic generalized epilepsy. Hypokalemic periodic paralysis is a genetically heterogeneous channelopathy that has been linked to mutations in genes encoding three ion channels CACNIAS, SCN4A, and KCNJ2 predominantly. Although data on specific gene in idiopathic generalized epilepsy is relatively scarce, mutations of voltage gated sodium channel subunit genes (CACNB4) and nonsense mutations in voltage gated calcium channels (CACNA1A) have been linked to idiopathic generalized epilepsy in two families. We speculate that gene mutations altering the ability of the beta subunit to interact with the alpha subunit of the CaV1.1 channel and mutations in the pore-forming potassium channel subunit may be possible explanations for the combined manifestation of both diseases. Functional analysis of voltage gated calcium channel and other ion channels mutations may provide additional support and insight for the causal role of these mutations. The understanding of mutations in ion-channel genes will lead to improved diagnosis and treatment of such inherited channelopathies.
The Analysis of Sialylation,N-Glycan Branching, and Expression ofO-Glycans in Seminal Plasma of Infertile Men
Authors: Kratz Ewa M. , Kałuża Anna , Zimmer Mariusz , Ferens-Sieczkowska Mirosława
Published: March 2015

Carbohydrates are known to mediate some events involved in successful fertilization. Although some studies on the glycosylation of seminal plasma proteins are available, the total glycan profile was rarely analyzed as a feature influencing fertilization potential. In this work we aimed to compare some glycosylation traits in seminal plasma glycoproteins of fertile and infertile men. The following findings emerge from our studies: (1) in human seminal plasma the presence and alterations ofO-linked glycans were observed; (2) the expression of SNA-reactive sialic acid significantly differs between asthenozoospermia and both normozoospermic (fertile and infertile) groups; (3) the expression of PHA-L-reactive highly branchedN-glycans was significantly lower in oligozoospermic patients than in both normozoospermic groups. Indication of the appropriate lectins that would enable the possibly precise determination of the glycan profile seems to be a good supplement to mass spectrum analysis. Extension of the lectin panel is useful for the further research.
Myocardial Hypertrophic Preconditioning Attenuates Cardiomyocyte Hypertrophy and Slows Progression to Heart Failure Through Upregulation of S100A8/A9
Authors: Wei Xuan , Wu Bing , Zhao Jing , Zeng Zhi , Xuan Wanling , Cao Shiping , Huang Xiaobo , Asakura Masanori , Xu Dingli , Bin Jianping , Kitakaze Masafumi , Liao Yulin
Published: March 2015

Background—

Transient preceding brief ischemia provides potent cardioprotection against subsequent long ischemia, termed ischemic preconditioning. Here, we hypothesized that transient short-term hypertrophic stimulation would induce the expression of hypertrophy regression genes and render the heart resistant to subsequent hypertrophic stress, and slow the progression to heart failure, as well.

Methods and Results—

Cardiomyocyte hypertrophy was induced in mice by either transverse aortic constriction or an infusion of phenylephrine, and in neonatal rat ventricular cardiomyocytes by norepinephrine exposures. In the preconditioning groups, hypertrophic stimulation was provided for 1 to 7 days and then withdrawn for several days by either aortic debanding or discontinuing phenylephrine or norepinephrine treatment, followed by subsequent reexposure to the hypertrophic stimulus for the same period as in the control group. One or 6 weeks after transverse aortic constriction, the heart weight/body weight ratio was lower in the preconditioning group than in the control group, whereas the lung weight/body weight ratio was significantly decreased 6 weeks after transverse aortic constriction. Similar results were obtained in mice receiving phenylephrine infusion and neonatal rat ventricular cardiomyocytes stimulated with norepinephrine. Both mRNA and protein expression of S100A8 and S100A9 showed significant upregulation after the removal of hypertrophic stimulation and persisted for 6 weeks in response to reimposition of transverse aortic constriction. The treatment with recombinant S100A8/A9 inhibited norepinephrine-induced myocyte hypertrophy and reduced the expression of calcineurin and NFATc3, but the silencing of S100A8/A9 prevented such changes.

Conclusions—

Preconditioning with prohypertrophic factors exerts an antihypertrophic effect and slows the progression of heart failure, indicating the existence of the phenomenon for hypertrophic preconditioning.
Early Lukács, Aesthetics of Politics?
Authors: Jameson Fredric
Published: March 2015

This article explores the unique status accorded to aesthetics in György Lukács’s work, with particular focus on his Heidelberg writings of the 1910s, and their thematic echoes in Lukács’s late Aesthetics, straddling the shift in Lukács’s philosophical framework from neo-Kantianism and Weberianism to Hegelian Marxism. It suggests that these writings, discovered after Lukács’s death and still marginal to scholarship on the Hungarian thinker, provide a singular illumination on many of the leitmotivs of Lukács’s oeuvre. In particular, the essay considers the shapes taken in these early writings by the subject-object dialectic and the concept of form, as well as the foreshadowings of Lukács’s theories of ideology and standpoint.
Commerce, Culture and Capitalism
Authors: Post Charles
Published: March 2015

The problem of commerce in pre-capitalist societies has been an issue debated among historians, both Marxian and non-Marxian, for over a century. Martha Howell’s book provides new historical data on the economic impact and cultural meaning of commerce in feudal Europe, without, however, addressing key theoretical and interpretive issues.
The Ontology Wars
Authors: Manning Francesca
Published: March 2015

Pierre Macherey’sHegel or Spinoza?suggests that Hegel was driven to his now legendary misinterpretations of Spinoza because he could not accept Spinozism without compromising his own philosophy. Macherey shows us a Spinoza that pre-emptively resists and challenges Hegel’s understanding of Spirit as Subject realising itself through self-negation and contradiction. This review draws out the central arguments in the book, and those arguments most salient for contemporary theories of capitalism and revolution, and points towards possible implications for Marxist theory.
Gender as Social Temporality: Butler (and Marx)
Authors: Arruzza Cinzia
Published: March 2015

This article addresses the notions of gender performativity and temporality in Butler’s early work on gender. The paper is articulated in four steps. First it gives an account of the role and nature of temporality in Butler’s theory of gender performativity. Second, it shows some similarities and connections between the role played by temporality in Butler’s theory of gender performativity and its role in Marx’s analysis of capital. Third, it raises some criticisms of Butler’s understanding of temporality and historicity, focusing in particular on the lack of historicisation of her own categories in bothGender TroubleandBodies that Matter. This deficit is a consequence of the epistemological framework within which she is operating, in particular of her understanding of social practices and relations through the lens of linguistic concepts extrapolated from their theoretical context. The article concludes by referring to Floyd’s and Hennessy’s analyses of the formation of sexual identities as examples of the fruitful historicisation of gender performativity, which also sheds some light on the ‘the abstract character’ of the temporality of gender performativity.
Revisiting the Turbulent Prandtl Number in an Idealized Atmospheric Surface Layer
Authors: Li Dan , Katul Gabriel G. , Zilitinkevich Sergej S.
Published: March 2015

Cospectral budgets are used to link the kinetic and potential energy distributions of turbulent eddies, as measured by their spectra, to macroscopic relations between the turbulent Prandtl number (Prt) and atmospheric stability measures such as the stability parameter ζ, the gradient Richardson number Rg, or the flux Richardson number Rf in the atmospheric surface layer. The dependence of Prt on ζ, Rg, or Rf is shown to be primarily controlled by the ratio of Kolmogorov and Kolmogorov–Obukhov–Corrsin phenomenological constants and a constant associated with isotropization of turbulent flux production that can be independently determined using rapid distortion theory in homogeneous turbulence. Changes in scaling laws of the vertical velocity and air temperature spectra are also shown to affect the Prt–ζ (or Prt–Rg or Prt–Rf) relation. Results suggest that departure of Prt from unity under neutral conditions is induced by dissimilarity between momentum and heat in terms of Rotta constants, isotropization constants, and constants in the flux transfer terms. A maximum flux Richardson number Rfm predicted from the cospectral budgets method (=0.25) is in good agreement with values in the literature, suggesting that Rfm may be tied to the collapse of Kolmogorov spectra instead of laminarization of turbulent flows under stable stratification. The linkages between microscale energy distributions of turbulent eddies and macroscopic relations that are principally determined by dimensional considerations or similarity theories suggest that when these scalewise energy distributions of eddies experience a “transition” to other distributions (e.g., when Rf is increased over Rfm), dimensional considerations or similarity theories may fail to predict bulk flow properties.
Microphysical Properties of Convectively Generated Fall Streaks within the Stratiform Comma Head Region of Continental Winter Cyclones
Authors: Plummer David M. , McFarquhar Greg M. , Rauber Robert M. , Jewett Brian F. , Leon David C.
Published: March 2015

This paper presents analyses of the microphysical structure of comma head stratiform precipitation in 14 continental cyclones, focusing on fall streaks of hydrometeors produced by cloud-top convective generating cells. Data were obtained at temperatures between −4° and −45°C using in situ instrumentation and the W-band University of Wyoming Cloud Radar, all operated aboard the National Science Foundation/National Center for Atmospheric Research C-130. Analyses are presented first for a case study of one cyclone, followed by statistical analyses of the full dataset.

Using radar-based objective classifications, the statistical percentile number concentrations averaged 1.9 times larger within the fall streaks compared to the regions between them, and the corresponding ice water content and median mass diameter values averaged 2.2 and 1.1 times larger. Ice-phase conditions were predominant within the stratiform precipitation, with deposition and aggregation the primary ice growth mechanisms. No distinct vertical velocity signatures were associated with the fall streaks, and similar ice growth mechanisms were common within and between them.

Combined with observations of cloud-top generating cells in many of the same cyclones, these analyses provide a more complete description of the comma head microphysical structure and the physical processes producing precipitation. Whereas the generating cells are critical to nucleation and initial ice growth, the majority of ice growth (exceeding 90% of the median ice water contents in the case study) typically occurred below the generating-cell level, where enhanced moisture associated with synoptic-scale ascent was present.
Eco-Premium or Eco-Penalty? Eco-Labels and Quality in the Organic Wine Market
Authors: Delmas Magali A. , Lessem Neil
Published: March 2015

Eco-labels emphasize information disclosure as a tool to induce environmentally friendly behaviors by both firms and consumers. The goal of eco-labels is to reduce information asymmetry between producers and consumers over the environmental attributes of a product or service. However, by focusing on this information asymmetry, rather than on how the label meets consumer needs, eco-labels may send irrelevant, confusing, or even detrimental messages to consumers. In this article, the authors investigate how the environmental signal of eco-labels interacts with product characteristics such as brand, quality, and price. In a discrete choice experiment, the authors examine consumer response to two similar eco-labels for wine, one associated with a quality reduction and the other not. The results show that respondents preferred both eco-labeled wines over otherwise identical conventional counterparts when the price was lower and the wine was from a lower quality region. However, they preferred conventional, more expensive wine from a high-quality region. This preference indicates that respondents not only obtain some warm glow value from eco-labeled wine but also possibly interpret eco-labeling as a signal of lower quality. This relationship held across both types of eco-labels, meaning that consumers did not understand the difference between them. This research contributes to the literature on information disclosure policies by highlighting important elements for effective eco-labels. These elements include consumer awareness and understanding of the eco-label, and consumer willingness to pay for an eco-labeled product. The results emphasize the need to create eco-labels that communicate clearly both the environmental attributes and the private benefits associated with them.
Civilising processes and doping in professional cycling
Authors: Connolly John
Published: March 2015

This article contends that professional cyclists have undergone civilising processes in relation to doping within the sport. Drawing on the theoretical approach of Elias, the author argues that over time stronger shame feelings in relation to doping became part of the social habitus of professional cyclists and doping became increasingly ‘pushed behind the scenes’. Yet, contradictions and reversals persisted in attitudes and behaviour. These fractures and discontinuities occurred due to several interconnected processes: the role of suffering within the sport and the nature of mutual identification that developed around it, the specific structure of the figuration of professional cycle sport, and the slowness of a comprehensive and effective monopoly apparatus over the control of doping to emerge and the perceived legitimacy of this. Combined these processes generated a social habitus in which doping only very slowly came to be perceived as shameful and which varied across space and time. Despite this a civilising advance is evident.
A laboratory exercise to improve student understanding of dominant pole analysis and high-frequency modeling of Field Effect Transistors
Authors: Kim Ernest M , Schubert Thomas F
Published: March 2015

In the quest for increased student understanding of the principles underlying high-frequency response of Field Effect Transistor amplifiers, a laboratory exercise employing a unique method to determine the intrinsic transistor model capacitances was used. The method employs two simple measurements: determination of the high 3-dB frequency for a common-source amplifier being driven by a Thévenin source with two different output resistance values. Circuit simulation results utilizing these experimentally determined intrinsic capacitances show much greater correlation to experimental results than those typically obtained using manufacturer-supplied values. Students participating in the laboratory exercise reported good gains in knowledge levels and reasonable gains in confidence levels.
Repression by Proxy
Authors: Eck Kristine
Published: March 2015

Why do regimes delegate authority over a territory to nonstate militias, in effect voluntarily sacrificing their monopoly over the use of violence? This article argues that two factors increase the probability of states delegating control to a proxy militia, namely, military purges and armed conflict. Military purges disrupt intelligence-gathering structures and the organizational capacity of the military. To counteract this disruption, military leaders subcontract the task of control and repression to allied militias that have the local intelligence skills necessary to manage the civilian population. This argument is conditioned by whether the state faces an armed insurgency in a given region since intelligence, control, and repression are needed most where the state is being challenged. This hypothesis is tested on unique data for all subnational regions within Myanmar during the period 1962 to 2010 and finds that proxy militias are more likely to be raised in conflict areas after military purges.
Disruption of Tgfbr2 in Odontoblasts Leads to Aberrant Pulp Calcification
Authors: Ahn Y.H. , Kim T.H. , Choi H. , Bae C.H. , Yang Y.M. , Baek J.A. , Lee J.C. , Cho E.S.
Published: March 2015

Transforming growth factor β (TGF-β) signaling has been implicated in dentin formation and repair; however, the molecular mechanisms underlying dentin formation remain unclear. To address the role of TGF-β signaling in dentin formation, we analyzed odontoblast-specific Tgfbr2 conditional knockout mice. The mutant mice had aberrant teeth with thin dysplastic dentin and pulpal obliteration, similar to teeth from human patients with dentinogenesis imperfecta type II and dentin dysplasia. In mutant, the odontoblasts lost their cellular polarity, and matrix secretion was disrupted after mantle dentin formation. As a consequence, the amount of predentin decreased significantly, and an ectopic fibrous matrix was formed below the odontoblast layer. This matrix gradually calcified and obliterated the pulp chamber with increasing age. Immunohistochemistry revealed decreased expression of alkaline phosphatase in mutant odontoblasts. In mutant dentin, Dsp expression was reduced, but Dmp1 expression increased significantly. Collagen type I, biglycan, and Dsp were expressed in the ectopic matrix. These results suggest that loss of responsiveness to TGF-β in odontoblasts results in impaired matrix formation and pulpal obliteration. Our study indicates that TGF-β signaling plays an important role in dentin formation and pulp protection. Furthermore, our findings may provide new insight into possible mechanisms underlying human hereditary dentin disorders and reparative dentin formation.
Norepinephrine Regulates Condylar Bone Loss via Comorbid Factors
Authors: Jiao K. , Niu L. , Xu X. , Liu Y. , Li X. , Tay F.R. , Wang M.
Published: March 2015

Degenerative changes of condylar subchondral bone occur frequently in temporomandibular disorders. Although psychologic stresses and occlusal abnormalities have been implicated in temporomandibular disorder, it is not known if these risks represent synergistic comorbid factors that are involved in condylar subchondral bone degradation that is regulated by the sympathetic nervous system. In the present study, chronic immobilization stress (CIS), chemical sympathectomy, and unilateral anterior crossbite (UAC) were sequentially applied in a murine model. Norepinephrine contents in the subjects’ serum and condylar subchondral bone were detected by ELISA; bone and cartilage remodeling parameters and related gene expression in the subchondral bone were examined. Subchondral bone loss and increased subchondral bone norepinephrine level were observed in the CIS and UAC groups. These groups exhibited decreased bone mineral density, volume fraction, and bone formation rate; decreased expressions of osterix, collagen I, and osteocalcin; but increased trabecular separation, osteoclast number and surface, and RANKL expression. Combined CIS + UAC produced more severe subchondral bone loss, higher bone norepinephrine level, and decreased chondrocyte density and cartilage thickness when compared to CIS or UAC alone. Sympathectomy simultaneously prevented subchondral bone loss and decreased bone norepinephrine level in all experimental subgroups when compared to the vehicle-treated counterparts. Norepinephrine also decreased mRNA expression of osterix, collagen I, and osteocalcin by mesenchymal stem cells at 7 and 14 d of stimulation and increased the expression of RANKL and RANKL/OPG ratio by mesenchymal stem cells at 2 h. In conclusion, CIS and UAC synergistically promote condylar subchondral bone loss and cartilage degradation; such processes are partially regulated by norepinephrine within subchondral bone.
The Career Decision State and Rehabilitation Counselor Education Programs
Authors: Leierer Stephen J. , Wilde Caroline K. , Peterson Gary W. , Reardon Robert C.
Published: March 2015

Undergraduate and graduate students enroll in rehabilitation counselor education programs with varying degrees of commitment to a career goal in the field. The career decision state (CDS) comprising certainty, satisfaction, and clarity is a snapshot of one’s career goals. It is bidimensional, differentiates between undergraduate and graduate rehabilitation counseling students, and is associated with negative career thinking. Implications for using CDS in the form of a brief questionnaire, in student orientation and ongoing advising, and in future research are discussed.
Effect of garment properties on air gap thickness and the contact area distribution
Authors: Frackiewicz-Kaczmarek Joanna , Psikuta Agnes , Bueno Marie-Ange , Rossi René M
Published: March 2015

The heat and mass transfer in clothing is affected by the distribution of the air gap thickness and the contact area and this, in turn, results from the interaction between the geometrically complex shape of the human body, garment design, and fabric mechanical properties. In this study, the distribution of the air gap thickness and the contact area in typical shirts and undershirts were investigated using the three-dimensional scanning technique in relation to the garment style and fit, fabric properties, and body regions.

This study showed that at the upper trunk the air gap thickness was unaffected by both the garment style and the fit, whereas the shape of the contact area was changed only by the fit. At the lower body the air gap thickness and the contact area changed proportionally with the increase of the ease allowances in the garments. As expected, larger air gaps were formed in shirts but larger contact areas were observed in undershirts. Consequently, results indicated the possibility of modeling the size of air layers in clothing by proper selection of the fabric type and ease allowances in clothing for a given body shape.