bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of two mutant JASON-RELATED genes associated with unreduced pollen production in potato
Authors: Clot Corentin R. , Vexler Lea , Leyva-Perez Maria de La O , Bourke Peter M. , Engelen Christel J.M. , Hutten Ronald C.B. , de Belt José van , Wijnker Erik , Milbourne Dan , Visser Richard G.F. , Juranić Martina , Eck Herman J. van
Published: September 2023

In diploid potato the production of unreduced gametes with a diploid (2n) rather than a haploid (n) number of chromosomes has been widely reported. Besides their evolutionary important role in sexual polyploidisation, unreduced gametes also have a practical value for potato breeding as a bridge between diploid and tetraploid germplasm. Although early articles argued for a monogenic recessive inheritance, the genetic basis of unreduced pollen production in potato has remained elusive. Here, three diploid full-sib populations were genotyped with an amplicon sequencing approach and phenotyped for unreduced pollen production across two growing seasons. We identified two minor-effect and three major-effect QTLs regulating this trait. The two QTLs with the largest effect displayed a recessive inheritance and an additive interaction. Both QTLs co-localised with genes encoding for putative AtJAS homologs, a key regulator of meiosis II spindle orientation in Arabidopsis thaliana. The function of these candidate genes is consistent with the cytological phenotype of mis-oriented metaphase II plates observed in the parental clones. The alleles associated with elevated levels of unreduced pollen showed deleterious mutation events: an exonic transposon insert causing a premature stop, and an amino acid change within a highly conserved domain. Taken together, our findings shed light on the natural variation underlying unreduced pollen production in potato and will facilitate interploidy breeding by enabling marker assisted selection for this trait.
Comparative Analysis of Molecular Testing Methods for FGFR2 Fusion/Rearrangement in Intrahepatic Cholangiocarcinoma
Authors: Zhang Xin , Bai Qianming , Wang Yulin , Jiang Zhengzeng , Han Jing , Xue Cheng , Huang Kai , Luan Lijuan , Huang Xiaoyong , Huang Xiaowu , Shi Guoming , Hou Yingyong , Ji Yuan
Published: September 2023

Backgrounds: Targeted therapies for intrahepatic cholangiocarcinoma (ICC) patients with FGFR2 fusion/rearrangement have shown significant effectiveness. Reliable and efficient testing strategies for detecting FGFR2 fusion/rearrangement are crucial following FDA and NMPA approval.
Methods: A cohort of 226 cases underwent RNA-based NGS, DNA-based NGS, and break-apart FISH analysis to evaluate FGFR2 fusion/rearrangement. The fusion detection rates, fusion partner identification, and concordance between the methods were analyzed.
Results: The positive rates for each method were as follows: RNA-based NGS − 9.8% (22/225), DNA-based NGS − 7.1% (16/226), and break-apart FISH − 10.2% (23/226). The integrated approach increased the prevalence rate of FGFR2 fusion/rearrangement to 11.5% (26/226). Among the 26 positive cases detected by any of the three methods, only 15 cases (57.7%) showed positive results for all three techniques, resulting in an overall concordance rate of 95.1% (215/226). RNA-based NGS played a critical role in confirming the presence of oncogenic FGFR2 fusion in 77% (20/26) of the fusion-positive cases and uncovered five novel putative oncogenic fusions involving FGFR2 (A1CF, ANKS1B, FOXP1, TFEC, and DAAM2). The combination of RNA- and DNA-based NGS detected a total of 29 FGFR2 fusion/rearrangements in 23 out of 226 cases (10.2%), involving 23 partner genes. The most frequent fusion partner was BICC1 (21.7%), while others varied. Relative to the oncogenic FGFR2 fusions identified by the RNA-based NGS assay, DNA-based NGS exhibited a sensitivity of 70.0% and specificity of 99.0%, while FISH showed a sensitivity of 99.0% and specificity of 98.1%. Among the 23 cases with positive FGFR2-FISH results, 18 cases (78%) demonstrated the typical split 3'/5' pattern with a signal distance of ≥ 2, while 5 cases (22%) displayed atypical patterns, including 1 case with short split signals (signal distance < 2) and 4 cases with a single 5' signal.
Conclusion: FGFR2 fusion/rearrangement exhibits genetic heterogeneity. Although DNA-based NGS is highly specific and FISH is highly sensitive, the use of RNA-based NGS is crucial for detecting FGFR2 fusion/rearrangement. A combined approach utilizing RNA-based NGS, DNA-based NGS, and FISH assay is recommended to enhance the accuracy of identifying FGFR2 fusions.
Investigation of the radiation Shielding Behavior of Monocrystalline and Polycrystalline solar cell Using experimental, Geant4 Simulation Code and WinXCOM Database
Authors: Al-zaidi Ghsson Ali , Saudi H. A. , Nassar Ibrahim A. , Sedeek K.
Published: September 2023

This study focuses on the radiation shielding characteristics of monocrystalline and polycrystalline Si solar cells. The linear attenuation coefficient (µ) for both cell types has been measured. By measuring the cell density, the mass attenuation coefficient (µ/ρ) has been calculated. The photon absorption capacity of polycrystalline solar cells is detected to be higher than that of monocrystalline solar ones. Lattice disordering and grain-boundary defects may enhance gamma absorption. Theoretical calculations have been carried out using Win X-Com and GEANT4 code computer programs at various photon energies ranging from 80 to 2614 keV. A great agreement was found with the experimental results at all energies. Some shielding parameters based on the measured attenuation coefficient such as the effective atomic number (Zeff), the effective electron density (Nel), half value layer (HVL), and mean free path (MFP) have been calculated at different energies. Polycrystalline solar cells were found to have better shielding properties than monocrystalline cells since they have lower MFP values. Macroscopic effective removal cross sections (ΣR) for fast neutrons have been also calculated by applying the win X-com software. Polycrystalline solar cells have a higher ΣR value than monocrystalline cells. We can conclude that, in addition to energy conversion, photovoltaic systems are superior shielding materials for both gamma rays and neutrons.
TPI/LDPE/OC composites preparation and the properties of shape memory research
Authors: Zhang Tao , Jia Yuhui , Shen Ruibing , Zhao W , Liang Yurong
Published: September 2023

Triple shape memory materials currently have a wide range of applications in aerospace and healthcare, however, the lack of their mechanical properties limits their wider application. In order to overcome the problem of low mechanical properties of the triple shape memory composites, in this study, organoclay (OC), which is low-cost and has an intercalation-type structure, was introduced as a reinforcing phase in a trans-isoprene (TPI) with regular molecular chains and a low-crosslinking low-density polyethylene (LDPE) matrix. TPI/LDPE/OC shape memory composites (SMP) were prepared by melt blending and vulcanized by dynamic vulcanization technique. Since different OC contents have different effects on the properties of the composites, it is particularly important to select the appropriate OC content. A series of experiments were conducted to reveal the effect of OC content on the mechanical and shape memory properties of TPI/LDPE/OC composites. The results show that OC can form a stable and homogeneous intercalation structure in the composites when the OC incorporation amount is 2 phr, and the mechanical properties and triple shape memory properties of the composites are optimized. This study demonstrates that OC can improve the crystallinity and cross-linking of TPI/LDPE composites, thus providing potential value for the study of multiple shape memory material applications.
Preliminary report on ultrashort perioperative partial-breast irradiation with multicatheter interstitial brachytherapy for early-stage breast cancer
Authors: Sato Kazuhiko , Fuchikami Hiromi , Takeda Naoko , Natsume Nana , Kato Masahiro
Published: September 2023

PURPOSE
Perioperative partial-breast irradiation (PBI) with multicatheter interstitial brachytherapy (MIB) is less invasive and more convenient. This study aimed to compare ultrashort perioperative MIB-PBI and conventional MIB-PBI (cPBI).
METHODS
The trial was conducted on patients aged ≥ 40 years and those with T0–2 (≤ 3 cm), N0-mi, and negative margins on mammography. The locoregional recurrence (LRR) and toxicity rates were compared between ultrashort perioperative MIB-PBI (uPBI) at a dose of 25.2 Gy in 4 fractions and cPBI at a dose of 32 Gy in 8 fractions.
RESULTS
In total, 198 patients (151 with uPBI and 47 with cPBI) were evaluated. At a median follow-up of 20.1 months, one (0.66%) patient in the uPBI group had LRR. The 2-year ipsilateral breast tumor recurrence-free survival rates of the uPBI and cPBI groups were 98.7% and 100%, respectively. The highest toxicity grades were grade 1 in 23 (15.2%) and grade 2 in 2 (1.3%) patients in the uPBI group, and grade 1 in 8 (17.0%) and grade 2 in 1 (2.1%) patient in the cPBI group. None of the patients in the two groups presented with grade 3 and higher toxicities. The toxicity rates between the two groups did not significantly differ. Further, 22 (14.6%) patients in the uPBI group and 8 (17.0%) in the cPBI group, and 3 (2.0%) patients in the uPBI group and 1 (2.1%) in the cPBI had acute and late toxicities, respectively. Toxicities commonly occurred at ≤ 3 months after PBI. Nevertheless, the timing of toxicity development between the two groups did not significantly differ.
CONCLUSIONS
This preliminary report included a small sample size and had a short follow-up period. However, the local control and toxicity rates were similar between the uPBI and cPBI groups. Therefore, an ultrashort hypofraction schedule is feasible and safe for perioperative MIB-PBI.
Aspect-based sentiment analysis with weighted relational convolutional network and complementary learning
Authors: Yu Bengong , Chen Mingyue
Published: September 2023

Aspect-based sentiment analysis in the sight of fine-grained sentiment detects the sentiment polarities towards given aspects terms. The syntactic information of the dependency tree is utilized in existing methods mainly by modeling the equality of different dependencies, which lacks the ability to capture aspect-related globally syntactic information and ignores the importance of considering contextual information of specific aspects. To alleviate the above problems, we propose WRCN-CL with two tasks: Weighted Relational Convolutional Network (WRCN) and auxiliary task complementary learning (CL); Weighted Relational Convolutional Network dynamically assigns weights to prune the dependency tree by considering positional weights and semantic structure simultaneously; Complementary representation is an auxiliary task for knowledge enhancement by obtaining grammatical information related to specific aspects of words. The experimental results prove the effectiveness of the model, and by observing the results on all datasets its state-of-the-art performance proved.
Scanpro: robust proportion analysis for single cell resolution data
Authors: Looso Mario , Alayoubi Yousef , Bentsen Mette
Published: September 2023

In higher organisms, individual cells respond to signals and perturbations by epigenetic regulation or transcriptional adaptation. However, in addition to shifting the expression level of individual genes, the adaptive response of cells can also lead to shifts in the proportions of different cell types. Recent methods such as scRNA-seq allow for the interrogation of expression on the single cell level, and can quantify individual cell type clusters within complex tissue samples. In order to identify clusters showing differential composition between different biological conditions, differential proportion analysis has recently been introduced. However, bioinformatics tools for robust proportion analysis of both replicated and unreplicated single cell datasets are critically missing. In this manuscript, we present Scanpro, a modular tool for proportion analysis, seamlessly integrating into widely accepted frameworks in the Python environment. Scanpro is fast, accurate, supports datasets without replicates, and is intended to be used by bioinformatics experts and beginners alike.
IMPATIENT-qPCR: melting-temperature-shift based evolution monitoring of successful aptamer development in SELEX processes
Authors: Kissmann Ann-Kathrin , Bolotnikov Grigory , Li Runliu , Müller Franziska , Xing Hu , Krämer Markus , Gottschalk Kay-E. , Zaiser Emmily , Andersson Jakob , Weil Tanja , Rosenau Frank
Published: September 2023

SELEX (Systematic Evolution of Ligands by Exponential enrichment) processes aim on the evolution of high affinity aptamers as binding entities in diagnostics and biosensing. Aptamers can represent game-changers as constituents of diagnostic assays for the management of instantly occurring infectious diseases or other health threats. Without in-process quality control measures SELEX suffers from low overall success rates. We present a quantitative PCR method for fast and easy quantification of aptamers bound to their targets. Simultaneous determination of melting-temperatures (Tm) of each SELEX round delivers information on the evolutionary success via the correlation of increasing GC-content and Tm. Based on nine successful previous processes we show the functionality of the IMPATIENT-qPCR for polyclonal aptamer libraries and resulting individual aptamers. Based on the ease of this new evolution quality control, we hope to introduce it as a valuable tool to accelerate SELEX processes in general.
Combined Action of Pure Oxygen Pretreatment and Near-freezing Temperature Storage on the Quality of Fresh-cut Nectarines
Authors: Li Dandan , Li Lu , Zhao Ruxia , Ding Xu , Du Jin , Liu Tao , Li Xuejin , Pan Na , Zhao Wei , Chen Lan , Li Xihong , Jiang Yuqian
Published: September 2023

Fresh-cut fruits were convenient for consumers but vulnerable to quality deterioration, including browning, softening, and volatile aroma loss. In this study, the effects of pure oxygen (PO) pretreatment and near-freezing temperature (NFT) storage on fresh-cut nectarines were investigated, including changes in browning degree, color shift, enzyme activity, cell membrane permeability, antioxidant activity, and aroma components. Specifically, pure oxygen pretreatment increased the activity of the ROS-scavenger enzymes (POD and CAT), which endows fruit with resistance to environmental stresses before fresh cut and storage. Near-freezing temperature storage is extremely effective in inhibiting browning-related enzyme (PPO) activity and total phenolic content (TPC). Higher antioxidant level and anti-browning effects were observed in fresh-cut nectarines treated with PO + NFT, which demonstrated by the DPPH scavenging action, FRAP, enzyme activity ratios (Ratio 1 and Ratio 2). During the storage for 9 d, firmness of the tissue was preserved, MDA content and membrane permeability were suppressed, which delayed the development of fruit softening and the deformation of cell microstructure. In addition, SSC and TA of fresh-cut nectarines were also well preserved by PO + NFT, which maintained the physiological and metabolic qualities. Electronic nose tests revealed that PO + NFT postponed the volatile aroma deterioration of fresh-cut nectarines. In conclusion, PO + NFT is effective in maintaining the storage quality of fresh-cut nectarines.
Multilingual Image Captioning: Multimodal Framework for Bridging Visual and Linguistic Realms in Tamil and Telugu through Transformers
Authors: B Rohan Reddy , Gunti Swathi , R Prasanna Kumar , S Sridevi
Published: September 2023

Image captioning is a formidable challenge in the realms of computer vision and natural language processing. The limited availability of captioning mechanisms for non-English languages poses significant barriers for nonproficient English speakers. Specifically, Tamil and Telugu the most spoken languages in India, lack image captioning models capable of delivering accurate captions. Moreover, generating captions in Tamil and Telugu is a complex task due to their unique linguistic intricacies. Addressing these challenges requires advanced models capable of capturing long-range dependencies and generating contextually meaningful image captions. This research presents a multimodal deep learning framework that appropriately integrates InceptionV3, VGG16, and ResNet50 convolutional neural network architectures with multihead attention-based transformer architecture. By harnessing the multihead attention mechanism, our model effectively comprehends image context, handles linguistic complexity, and establishes vital multimodal associations between visual and textual features. Extensive experiments were carried out on translated versions of the benchmark datasets such as Flickr8k, Flickr30k, and MSCOCO to evaluate the efficacy of the model. The multimodal technique we suggested produced extraordinary and remarkable results especially in terms of BLEU metrics. The maximum value of the BLEU-1 score achieved by our suggested model reaches 65.16 and 66.79 on Tamil and Telugu caption generation tasks respectively. These findings outperformed the results of existing methods, indicating improved accuracy in generating captions for both Tamil and Telugu languages. Furthermore, a meticulous, manually labored audit of the generated captions confirmed their appropriateness and competence, affirming the robustness of the proposed methodology.
Mammary hydroxylated oestrogen activates the NLRP3 inflammasome in tumor-associated macrophages to promote breast cancer progression and metastasis
Authors: Zhao Han , Xu Jiahao , Zhong Ya’nan , He Shiqing , Hao Zhixiang , Zhang Bei , Liu Zhao , Zhou Xueyan
Published: September 2023

Background: An imbalance of oestrogen homeostasis and an inflammatory tumor microenvironment (TME) are vital risk factors for the progression and metastasis of breast cancer.
Methods: The liquid chromatography-tandem mass spectrometry (LC-MS/MS) quantitative analysis method for oestrogen active substances was used to detect the levels of oestrogen and its metabolites of 238 clinical serum samples, 6 clinical malignant breast cancer tissues and their corresponding non-tumor adjacent tissues and MMTV-PyMT mice mammary tissues. In vitro and in vivo experiments were conducted to investigate the correlation between oestrogen and tumor-associated macrophages (TAMs) and the role and mechanism of the NLRP3 inflammasome activated by oestrogen in promoting breast cancer progression and metastasis.
Results: Results of the present study demonstrated that tumor-associated macrophages (TAMs) were the main population of immune cells present in the breast TME. Thus, TAM-dependent tumor metastasis may be triggered by hydroxylated oestrogen via NOD-like receptor thermal protein domain associated protein 3 (NLRP3), inflammasome activation and IL-1β production. Mechanistically, TAM-derived inflammatory cytokines induced the expression of matrix metalloproteinases in breast tumor cells, leading to breast tumor invasion and metastasis. Collectively, these results revealed a previously unknown role of hydroxylated oestrogen in the reprogramming of the TME via NLRP3 inflammasome activation in TAMs. These mechanisms may facilitate breast cancer cell proliferation, migration and invasion.
Conclusions: The disorder of oestrogen metabolism in the breast, especially the abnormal elevation of hydroxylated oestrogen, may be a risk factor for the metastasis of breast tumors. Hydroxylated oestrogens act on TAMs to induce the generation of an inflammatory microenvironment in breast tumors, thereby regulating the progression of breast cancer.
Home Garden Characteristics among Lao’s Vulnerable Upland Rural Farmers in Phoukhoud District, Lao PDR
Authors: Shrestha Suraj , Maraseni Porf. Tek , Apan Porf. Armando
Published: September 2023

The provincial and district agriculture and forestry offices of Lao PDR and local civil society groups are implementing several agricultural production initiatives and recognize the importance that home gardens contribute tohousehold livelihood. Despite of its importance, studies on home garden characteristics among rural vulnerable households are limited. Thus, this study assesses home garden characteristics among three types of vulnerable upland rural farmer households in Phoukhoud District, Lao PDR: People with Disability Households (PWDHH), Female-headed Households (FHHH), and Other Vulnerable Households(OVHH). The study applied mixed methods by integrating both quantitative and qualitative data analysis.
The study shows that approximately 84% of households used home garden crops for household consumption, with 21% PWDHH, 29% FHHH, and 34% OVHH also selling surplus. We found home gardens near and far from homes, with sizes varying from smaller to largerplots; FHHHs home gardens appear to be the largest, furthest from their home and they spent more time, whereas PWDHH's home gardens were the closest, smaller, less time spent and harvested the most compared to other HHs. On average, 37% of vulnerable households harvested crops year-round.
Despite the unpaid domestic work disparity, women felt it empowered them as managers and owners of their home gardens. Eighty-three different varieties of edible plant-based crops were found in the home gardens, with FHHHs producing the fewest varieties and OVHHs producing the most varieties. They primarily used their own traditional seeds, mostly using traditional methods to select and store them, and experienced seed loss.
This study discusses the constraints and opportunities and provides recommendations for optimizing home garden management. The study supports Lao PDR’s National Agriculture Policies and Strategies and the call for an urgent plan to reduce exposure and vulnerability for farmers and contributes to attaining Sustainable Development Goals (SDGs) 2, 3, 12, 13, and 15.
Innovations in Marketing Communication in the Hospitality Business in Slovakia During the COVID-19 Pandemic
Authors: Lincenyi Marcel , Svejnova Hoesova Katarina , Fabus Michal
Published: September 2023

The main purpose of the article was to describe selected factors of hotel business in the Slovak Republic in the years 2001 to 2020 and identify the economic impacts of measures related to the pandemic crisis COVID-19 in 2020. At the same time through selected marketing tools. Paper is also focused on innovative marketing tools used in the hotel business during a pandemic time and their impact on business effectiveness. To analyze the situation in the hotel business in the Slovak Republic, we used a statistical method of comparison within the period under study. To obtain qualified answers to the stated research goals and subsequent research questions, we statistically processed available data on the number of domestic and foreign visitors, as well as the capacity of accommodation facilities in the monitored period. Subsequently, we carried out research in the hotel sector using the method of controlled structured interviews. The results were processed through exploratory factor analysis, based on which we were able to evaluate marketing tools with the most significant impact on efficiency in the hotel business in the Slovak Republic. The measures taken in connection with the coronavirus COVID-19 caused significant economic impacts on the hotel business in the Slovak Republic, as in 2020 the number of foreign visitors dropped to 20-year lows. The analysis of the environment in the hotel business for the period under study showed that the impact of measures within the COVID-19 pandemic had a significant impact on the number of visitors, the amount of revenues and the number of accommodation facilities. The research of structured interviews with accommodation facility managers showed that the use or non-use of marketing activities (websites, PPC advertising, social media) had a significant effect on the reduction of revenues. The findings of the analysis of the environment clearly show that the relaxation of the economic measures in the summer of 2020 increased the number of domestic visitors to a higher level than in the same period in 2019, but there was no increase in the number of foreign visitors. We can state that if the epidemic comes under control, there will be a massive increase in the number of visitors and thus an increase in revenues. In case, that Slovak hotel managers would use innovative marketing tools more in the future when communicating with potential customers, it is highly probable that their potential losses would be lower in the next crisis.
Эффективность режимов комбинированной лекарственной предтрансплантационной подготовки у пациентов с однократной трансплантацией аутологичных гемопоэтических стволовых клеток при множественной миеломе
Authors: Кострома Иван Иванович , Жук А. С. , Сидорова Ж. Ю. , Сабитова Р. Р. , Аксенова А. Ю. , Белопольская О. Б. , Бессмельцев С. С. , Сидоркевич С. В. , Грицаев С. В.
Published: September 2023

Aim. To conduct an interim outcome analysis of conditioning regimens with carfilzomib or thiotepa compared to standard melphalan 200 mg/m2 regimen in multiple myeloma (MM) patients with single autologous hematopoietic stem cell transplantation (auto-HSCT).

Materials & Methods. The retrospective analysis focused on outcomes of 67 single auto-HSCTs performed from 2017 to 2021. Responses as well as progression-free (PFS) and overall survival (OS) rates were compared in MM patients per IWMG criteria in pre- and post-transplant periods. Three conditioning regimens were assigned: melphalan 200 mg/m2 (Mel200), melphalan/carfilzomib combination (Mel/Karfil), and melphalan/thiotepa combination (Mel/Thio). In an additional cohort of 12 MM patients, next-generation sequencing assay was used to detect inherited and somatic mutations associated with proteasome inhibitor efficacy. For this purpose, DNA of peripheral blood lymphocytes and bone marrow plasma cells were examined.

Results. PFS medians were comparable in MM patients treated with Mel200 (n = 40) and Mel/Karfil (n = 10) conditioning regimens, they were 32 and 23 months, respectively (p = 0.241). In these cohorts, OS median was not reached, and the curves showed no significant differences (p = 0.050). Out of 10 MM patients treated with Mel/Karfil, six received melphalan 140 mg/m2, the remaining 4 patients received 200 mg/m2. Complete response (CR) rate in the Mel200 and Mel/Karfil groups increased two-fold after auto-HSCT: from 35.5 % to 74.2 % and from 25.0 % to 50.0 %, respectively. The worst PFS and OS medians were in the Mel/Thio group, i.e., 12 and 17 months, respectively, and CR rate after auto-HSCT remained unchanged. The best PFS was associated with CR rather than very good partial or partial response after auto-HSCT, they were 48, 21, and 23 months, respectively (p = 0.001). Exome sequencing of DNA of peripheral blood lymphocytes and bone marrow plasma cells revealed polymorphic variants in the genes associated with chemotherapy response.

Conclusion. The outcomes of Mel/Karfil, the regimen containing the reduced dose of melphalan 140 mg/m2, and the statistical comparability with the Mel200 regimen suggest that this combination can be effective in the treatment of MM patients with impaired renal function, which still needs to be further confirmed. No advantage of the combined conditioning regimen over the standard one can be accounted for by the loss of plasma cell sensitivity to proteasome inhibitors. The obtained data provide ground for modifying the study protocol with a particular focus on evaluating the efficacy and safety of conditioning regimen Mel/Karfil with melphalan 200 mg/m2 depending on biologic phenotype of plasma cell.
KIR-генетические факторы и ответ на терапию ингибиторами тирозинкиназ при хроническом миелоидном лейкозе
Authors: Кузьмич Елена Витальевна , Павлова И. Е. , Бубнова Л. Н. , Бессмельцев С. С.
Published: September 2023

The development of tyrosine kinase inhibitors (TKIs) and their introduction into clinical practice considerably improved the prognosis for chronic myeloid leukemia (CML) patients. About 50 % of patients with achieved deep molecular response are eligible for safe TKI discontinuation. Despite these advances, no reliable biomarkers are known to predict a response and sustaining treatment-free remission after TKI withdrawal. As TKIs do not destroy leukemic stem cells, which can be responsible for relapse, critical importance in CML is attached to natural killers (NK-cells) having antitumor activity. Functional activity of NK-cells is evaluated by expression level and repertoire of killer cell immunoglobulin-like receptors (KIR). Current studies demonstrate that a patient’s KIR genotype affects the probability of achieving early and deep molecular responses to first- and second-generation TKIs, progression-free and overall survivals, and sustaining treatment-free remission. On that ground, KIR-genetic factors can be regarded as promising predictors of response to TKI therapy in CML. Early clinical studies, which dealt with monoclonal antibodies blocking the inhibitory KIR in order to increase NK-cell activity, revealed an acceptable safety profile and efficacy in some hematological diseases (such as acute myeloid leukemia, multiple myeloma, Т-cell lymphoma) if used in combination with cytostatic drugs or antitumor monoclonal antibodies. KIR genotype determination can contribute to the development of effective therapies of this malignant hematological tumor.
The Linguistic Modernity among Youth Culture: The Moroccan Linguistic Context
Authors: AIT MAMA Assiya
Published: September 2023

This paper seeks to examine linguistic modernity within Moroccan youth culture in the context of social interactions. The study specifically focuses on the lexical and topical aspects of linguistic practices among young individuals. The research employs a combination of questionnaires and unstructured interviews to gather relevant data, which will then be subjected to a mixed-method analysis. The qualitative aspect involves analysing recorded interviews using discourse analysis, focusing on participants' interactions and examining the linguistic components of youth language, including lexicon and distinctive topics that differentiate them from older social groups. On the quantitative side, the research measured participants' utilization of innovations, code-switching, and compared gender-related aspects of youth language. This paper delved into various aspects of linguistic modernity within youth culture, particularly focusing on lexical and topical dimensions. Concerning lexicon, the results of the study revealed that young individuals forge novel collocations by creatively employing language. They incorporate slangs, both general and internet-specific, into their speech. Moreover, these youths display a propensity for inter-sentential code-switching, utilizing multiple languages in their discourse. Notably, social media and technology emerge as predominant themes in their conversations. While youth language is a distinctive facet of their linguistic behaviours, paralinguistic practices also exemplify their generational characteristics. Likewise, the quantitative findings collectively suggest that young people in Morocco are adaptable in their language usage, often incorporating new expressions from various sources, code-switching, and displaying an interest in both Western and Asian languages.
VERITAS highlights of observations and results
Authors: Patel Sonal Ramesh
Published: September 2023

Located in southern Arizona, VERITAS is amongst the most sensitive detectors for astrophysical very high energy (VHE; E>100 GeV) gamma rays and has been operational since April 2007. We highlight some recent results from VERITAS observations. These include the long-term observations of the gamma-ray binaries HESS J0632+057 and LS I +61° 303, the observations of the Galactic Center region, and of the supernova remnant Cas A. We discuss the results from a decade of multi-wavelength observations of the blazar 1ES 1215+303, the EHT 2017 campaign on the M87 galaxy, the discovery of 3C 264 in VHE, and the observation of three flaring quasars. Brief highlights of the indirect dark matter searches and targets-of-opportunity (ToO) observations are also discussed. The ToO observations allow for rapid follow-up of multi-messenger alerts and astrophysical transients.
The all-particle energy spectrum of cosmic rays from 10 TeV to 1 PeV measured with HAWC
Authors: Morales-Soto Jorge Antonio , Arteaga-Velázquez Juan Carlos
Published: September 2023

The HAWC observatory is an air-shower detector, which is designed to study both astrophysical gamma-rays in the TeV region and galactic cosmic rays in the energy interval from 1 TeV to 1 PeV. This energy regime is interesting for cosmic ray research, since indirect observations overlap with direct measurements, which offers the opportunity for cross calibration and studies of experimental systematic errors in both techniques. One quantity that could help for this purpose is the all-particle energy spectrum of cosmic rays. In this work, we present an update of HAWC measurements on the total cosmic-ray energy spectrum between 10 TeV and 1 PeV. The spectrum was obtained from an unfolding analysis of almost two years of HAWC’s data, which was collected from January, 2018 to December, 2019. For the energy estimation, we employed the high-energy hadronic interaction model QGSJET-II-04. As in a previous work of HAWC, published in 2017, we observed the presence of a knee-like feature in the region of tens of TeV.
THE TOLAKI CALENDAR SYSTEM FOR DETERMINING GOOD AND BAD DAYS
Authors: Ridhayanti Nurul Resky
Published: September 2023

The Tolaki people continue to base their way of life on traditions like the Tolaki calendar for identifying good and bad days. The Tolaki tribe employs a tool that is often employed as a weather forecast or as a guide for the community to carry out certain actions to ascertain this. The formulation of the issue is brought up by the author, who asks questions like: How does the Tolaki calendar system work?, How are the good and bad days for the Tolaki people determined?, and How is astronomical research related to the Tolaki calendar system?. The Tolaki Culture Book, which is processed with journals linked to the Tolaki Tribal Calendar System, is used in this research technique, which is a library method. It is studied descriptively and presented qualitatively. These are the study's findings: The moon's position in the night sky is used as the basis for the Tolaki calendar. The meanings of the names of the days in the month are used by the Tolaki people to identify good and bad days, and they use Naga Hari, Kutika, and Bilangari to ascertain the precise day and hour. The Tolaki calendar is identical to the Hijri calendar in astronomy since it uses a lunar calendar that keeps track of the moon's orbit. The Tolaki community uses the concept of good days and bad days as a guide for carrying out activities, but it cannot be utilized as a model for how to do Islamic devotion.
Luta por outro reconhecimento
Authors: Tidre Polyana
Published: September 2023

Esta contribuição tem por intuito apresentar duas críticas feitas à teoria do reconhecimento de Axel Honneth. Primeiramente, será exposta a crítica feita por Jacques Rancière em Recognition or disagreement às concepções de “reconhecimento” e “luta por reconhecimento” honnethianas. Mostrar-se-á em que medida, para Rancière, tais concepções, podendo ser entendidas como “identitaristas” e pressupondo uma noção de relações sociais marcadas por reciprocidade ou simetria, fracassariam na reivindicação por “uma forma mais larga de universalismo”. Em seguida, será apresentada a crítica de Safatle à concepção de reconhecimento honnethiana, sobretudo a partir da argumentação desenvolvida em Grande Hotel Abismo. Buscar-se-á mostrar como Safatle, contrapondo-se a Honneth, propõe um retorno a Hegel para defender uma concepção de reconhecimento na qual o “outro” não deve ser entendido meramente como uma outra consciência-de-si dotada de um sistema de interesses próprio, mas como “uma alteridade mais profunda” – o que implicaria no entendimento da confrontação com o elemento do indeterminado ou do negativo como uma experiência fundamental no processo de formação da identidade.
ENTORNO URBANO IMEDIATO
Authors: Sales Laina Priscila de Oliveira , Michels Caren
Published: September 2023

Neste artigo, é apresentado uma avaliação pós ocupação de entorno urbano imediato, considerando os atributos de funcionalidade, técnicos ambientais, estético formais e comportamentais. Para isso, realizou-se um estudo de caso no condomínio residencial Cidadão Manauara 2 localizado na cidade de Manaus, Amazonas. Observou-se que a arquitetura contemporânea ainda é influenciada por programas arquitetônicos capitalista do século passado, cujos projetos atuais tem sido conduzidos de forma estandardizadas, em série e que portanto, necessitam de revisão a fim de contemplar nas áreas de especial interesse social mais áreas verdes, áreas de lazer, mobiliários urbanos, calçamentos adequados, arruamento e acessibilidade antes mesmo de implantarem um empreendimento residencial e gerar um novo contingente urbano que demanda um aumento da capacidade de atendimento quantos aos serviços que compõem um programa habitacional. Foi destacado ainda que o planejamento urbano é fundamental para estabelecer as regras de boa conduta e interação social, concluindo-se que é necessário desenvolver políticas públicas que contemplem de forma mais intensa estes atributos em espaços e bairros destinados às habitações de interesse social a fim de promover soluções de qualidade de vida, sustentabilidade e satisfação do usuário.
Marketplaces vs Shopping Malls: Today’s Trends and Forecasts
Authors: Stukalova I. B.
Published: September 2023

Nowadays in line with traditional off-line trade e-trade develops fast enough. Today’s customers show higher interest and loyalty to marketplaces. The goal of the article is to investigate new institutions being formed on the trade landscape, to analyze standing and current trends and factors influencing the development of shopping malls and marketplaces. The author’s hypothesis implies that in present conditions of trade development marketplaces act as an alternative and key competitors to shopping malls, as earlier shopping malls themselves became an alternative to department stores. Today we can observe that a certain part of customers and purchases leave off-line and choose on-line due to economic, social and geo-political reasons. It was promoted by digital technologies, COVID-19 pandemic and its after-effects, changes in customer behavior model, impact of sanction pressure on consumer market and so on. The author supposes that in case the current trend of fast growth of e-trade continuous (including marketplaces), by 2027 no less than 45% of all purchases will be done at marketplaces, while the share of traditional trade will drop and the role of shopping mall will reduce.
Greenwashing or Current Positioning of Goods
Authors: Magomedova G. M.
Published: September 2023

The article studies one type of current goods positioning, i. e. greenwashing. Greenwashing is company activity, in which various marketing communications (PR and advertising) are used to demonstrate its ecological orientation instead of real introduction of ecological practices aimed at cutting the negative impact on the environment. The author describes history of greenwashing, provides examples and discusses strategies that help check the current company positioning for using greenwashing. The difference between green marketing and greenwashing was explained. Green marketing is a marketing activity, as a result of which the company sells its products or services orientating only to their ecological properties. The article also studies the problem of transparency and corporate social responsibility. Corporate social responsibility means practice of sustainable development, whose goal is to ensure gains, such as economic, ecological and social benefits for producer and consumer. Complete transparency is a conviction that all organizations must be frank, open and honest in their work. Types of greenwashing regulation (legal, public, professional) are characterized.
Innovation Technologies in Sport Nutrition
Authors: Prokhoda I. A. , Feshchenko V. V. , Galicheva T. A. , Myasnikova E. N.
Published: September 2023

The article provides findings of the research dealing with innovation technologies in sport nutrition using unconventional sources, i. e. apiculture products in order to raise immune-response of sports people. Four experimental groups were chosen: the 1st group included people taking a certain composition of honey with pollen in ratio 5 : 100; the 2nd group – people taking a mixture of honey with bee-glue in ratio 2 : 100; the 3rd group – people taking honey with royal jelly in ratio 1 : 100 and the 4th group – control one. As a result of innovation technology application, i.e. using unconventional raw material a serious rise in immune-response of sports people was observed due to their food status. The authors’ research gives an opportunity to widen the range of using innovation technologies in order to improve functional properties of food for sport nutrition.
Topicality of K. Marx Economic Doctrine in Today’s Conditions Illustrated by Collective Management Functioning
Authors: Gerasev I. A.
Published: September 2023

The article analyzes the role of collective management enterprises as an example of practical application of Marxist economic theory in today’s market economy. The goal of the research is to search for suggestions appropriate for solving the problem of fair distribution of labour product illustrated by functioning of enterprises with collective forms of property in present day economy. This problem was elaborated in works by theoreticians of Marxist and neo-Marxist economic schools and in current conditions of private market economy. A positive aspect of the Marxist theory was identified in the sphere of fair distribution of labour product and aspiration for production democracy. Topicality of these problems in current social and economic conditions was demonstrated. Arising of the concept of public enterprises and its realization within the frames of different economic models was analyzed illustrated by such countries as the US, Great Britain, Italy and some others. Economic results of such enterprises were studied and their higher economic efficiency in comparison with enterprises of other forms of property was shown. The demand for justice in social and economic sphere of production in market economy was highlighted. Special attention was paid to the role of enterprises with collective forms of management in economic systems of Russia and China, the efficiency of collective enterprises was analyzed and legal aspects of their functioning were studied. As a result of the research certain drawbacks in collective enterprise work were revealed, for instance, undeveloped interaction with the banking environment, insufficient legal base of their functioning and poor information of the population. The article proved the importance of enterprises with collective form of management as a factor of labour productivity rising and underlined significance of the social aspect of their work. Topicality of the issue of social justice in labour product distribution was shown in the context of positive heritage of the Marxist theory. On the basis of the research key practical suggestions aimed at developing the system of enterprises with collective form of property were formulated.
Functional Model of Credit System
Authors: Revtova E. G.
Published: September 2023

The subject of the research is the process of credit functioning, its goal is to develop a functional model of credit system. The research hypothesis assumes that credit continuous development ensures its adaptation to the changing environment. Methodology of the research was made up by the universal academic method, i. e. the outline of functional system, the method of analogies and critical analysis of literature. Within the elaborated functional model of the credit system components of credit were identified: store unit, two units of subsystem and resources providing its adaptation to the impact of the environment; mechanisms of organization and self-organization were substantiated; ways of transforming credit functional system in response to environment changes were demonstrated. The elaborated functional model of the credit system provides systematic comprehension of the process of credit functioning; explains the character of outward impact on the credit system and resources ensuring response to this impact; elucidates processes of organization and self-organization in the credit system. The obtained results can contribute to the development of academic theory of credit, give extra opportunities for grounding the objective regularities of its continuous development and propose additional ways for developing mechanisms of credit management.
The Role of Large Corporations of Non-Ferrous Metallurgy in Providing Revenues of Regional Budgets Illustrated by Krasnoyarsk Territory (the public company ‘Norilsk Nickel’) and Irkutsk Region (the public company ‘OK RUSAL’)
Authors: Malyshev M. K.
Published: September 2023

Invariably high role of large tonnage and low-added-value business in economy of the Russian Federation stipulates topicality of such research. Big business reaching 78-80% of Russian GDP will continue playing the primary role, which will be backed by exchange rate in exporters’ interests and their raw material orientation. Iron and steel industry in Russia by budget, production and export significance yields only to oil and gas sphere. Ferrous and nonferrous metallurgy produces the most important construction materials for other industries and at the same time keeps up the demand for highly-qualified workers with rather high level of wages. The goal of the research is to identify the contribution of large companies of non-ferrous metallurgy to revenues of the Russian Federation budget system. For this end the authors analyzed accounts of companies with budget system on profit tax, on value-added tax, tax on individuals and tax on company property. Information base of the research was formed by works of home and overseas authors that show the role of large corporations in social and economic development of regions and countries, Rosstat data, information of the Federal Taxation Service on the Irkutsk region and the Krasnoyarsk territory, official annul and finance accounting of the public company ‘OK RUSAL’ and the public company ‘Norilsk Nickel’.
Historical and Cultural Tradition of Organizing Labour Activity in Russia and Its Impact on Today’s Economic Mentality of Russian Citizens
Authors: Bezveselnaya Z. V.
Published: September 2023

The article deals with issues concerning the condition and development of national economic mentality of Russian citizens in view of historical and cultural, as well as historical and economic heritage of the country, historical specific features of shaping economic and managerial culture. According to the author, humanization, democratization and optimization of managerial culture with due regard to specificity of national economic culture are essential pre-conditions for the process. Issues of today’s labour and management culture in Russia are investigated in close relation with the Russian cultural model, economic mentality of Russian citizens formed during previous centuries and historic experience of organizing production processes in the Russian empire and the USSR. For this research the author used a combination of historical and logical methods in line with the statistical method, analysis of historic sources, as well as the method of comparative analysis.