bluuebunny/crossref_metadata_2025 huggingface dataset:
Mir-186 inhibits the proliferation and growth of multiple myeloma cells by targeting Jagged-1 expression
Authors: Dong Jinfeng , Zheng Xiaoqiang
Published: February 2024

Purpose: To investigate the suppressive influence of mir-186 on multiplication and growth of multiple myeloma (MM), as well as the processes involved.Methods: The U266 cells were divided into control, mir-186 overexpression, and inhibition groups. The latter two were transfected with  mir-186 agent and antagonist, respectively. Cell viability, colony formation potential, cell cycle ratio, and Jagged-1 mRNA and protein  levels were measured using various assays.Results: Cell growth increased over time in all groups. However, mir-186 overexpression cells showed significantly decreased growth and  colony formation capacity, relative to control, while the mir-186 inhibition cells showed significantly higher growth and colony formation  capacity. The study revealed a higher proportion of G0/G1 stage cells and lower proportion of S-phase cells in mir-186 overexpression cells than in control cells. The opposite effect was seen in mir-186 inhibition cells. Jagged-1 protein and mRNA levels were significantly  lower in mir-186 overexpression cells and higher in mir-186 inhibition cells than in control group. The Jagged-1 knockout group showed  significantly higher Jagged-1 mRNA and protein levels than both the control and mir-186 overexpression groups (p < 0.05).Conclusion: When overexpressed, mir-186 inhibits the growth of multiple myeloma cells by inhibiting cell colony-formation capacity and  by regulating cell cycle through mir-186-induced regulation of the expression of Jagged-1. there is need for more research to confirm the  clinical benefits of therapies based on these findings.
Cytotoxicity of luteolin, a flavonoid compound isolated from Anthemis palestina
Authors: Tabaza Yahia Z. , Seong Zuh-Kyung , Kim Young-Mi , Alshaer Walhan , Aburjai Talal A.
Published: February 2024

Purpose: To determine the active principle responsible for the cytotoxic effect of Anthemis palestina (Reut. ex Kotschy) Reut. ex Boiss. (Asteraceae).

Methods: A bioassay-guided fractionation was used to isolate the active principle, luteolin, which structure was elucidated using 1H and   13C NMR. The cytotoxic effects of luteolin and doxorubicin (positive control) in the breast cancer cell lines MDA-MB-231 and MCF-7, and in normal fibroblasts, were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay.

Results: Luteolin was isolated from the ethyl acetate extract of the aerial parts of Anthemis palestina. With an IC50 value of 14.91 ± 5.77  µM for MDA-MB-231 cells, luteolin was less active than doxorubicin. However, with respect to MCF-7 cells, there was no significant  difference in the cytotoxicity values of luteolin and doxorubicin, with IC50 value of 29.28 ± 11.85 µM for luteolin. However, with an IC50  value of 51.39 ± 18.51 µM against fibroblasts, luteolin was significantly safer than doxorubicin.

Conclusion: Luteolin might be responsible  for the cytotoxicity of Anthemis palestina. The high level of luteolin cytotoxicity indicates the potential benefits of Anthemis palestina, not  only in terms of its taste, but also for its likely positive therapeutic impact on cancer, especially breast cancer.
Clinical efficacy of polysaccharide iron complex plus vitamin C in the treatment of iron deficiency anemia in pregnancy and their effect on iron metabolism
Authors: Qiu Changhui , Tao Tao , Xia Zhixin , Fang Jing
Published: February 2024

Purpose: To evaluate the clinical efficacy of polysaccharide iron complexes (PIC) plus vitamin C in treating iron deficiency anemia (IDA) during pregnancy and its effect on iron metabolism.Methods: Ninety pregnant women with IDA in their second trimester admitted into the Department of Gynaecology and Obstetrics, Nanchang Third Hospital, Jiangxi Province, China between June 2019 and June 2021 were randomly and equally assigned to receive either PIC (two 500 mg capsules daily) alone (control group) or PIC plus vitamin C (0.1 g daily) (study group) for 4 weeks. Efficacy was determined by changes in clinical symptoms and blood indices and iron metabolism indices (serum ferritin, serum iron, hepcidin, transferrin saturation) pre- and post-treatment. Adverse pregnancy outcomes were also recorded.Results: Both groups were comparable at baseline. Post-treatment, study group showed significantly higher red blood cell (RBC), hemoglobin (Hb), mean red blood cell volume (MCV) and mean corpuscular hemoglobin (MCH) compared to control group (p < 0.05). Iron metabolism indices also significantly improved in study group with serum ferritin (SF), serum iron (SI), hepcidin (Hepc), and transferrin saturation (TSAT) (p < 0.05). The total clinical efficacy was higher in study group (p < 0.05), and the incidence of adverse pregnancy outcomes was lower (p < 0.05).Conclusions: The combination of PIC with vitamin C significantly improves the hematological indices, enhances iron metabolism, and reduces adverse pregnancy outcomes compared to PIC alone in pregnant women with IDA. Further studies with larger sample sizes are warranted to validate these results.
Individualized treatment strategy for patients with rheumatoid arthritis based on imaging evaluation
Authors: Xiaoli Fan , Yanhua Fan , Juan Wang , Shunlin Bu , Rong Chen , Xiaoli Pang , Mingliang Chen , Longxiang Wang
Published: February 2024

Purpose: To study the effect of individualized treatment strategy based on imaging evaluation in patients with rheumatoid arthritis (RA).

Methods: Eighty patients with RA of the wrist treated in the Second Affiliated Hospital of Nanjing Medical University, China from January  2018 to December 2022 were assigned to control and study groups. Conventional methods were used for treating control subjects, based  on RA laboratory index results, while the study group received individualized treatment based on RA laboratory index results and results  of imaging evaluation. Before and after treatment, serum levels of rheumatoid factor (RF) and C-reactive protein (CRP) were assayed  using immunoturbidimetry. Erythrocyte sedimentation rate (ESR) was determined by Wei method. Imaging examination - ultrasound or  magnetic resonance imaging (MRI) - was carried out in study group before and after treatment. Disease activity score 28 (DAS28) and  score on the visual analogue scale (VAS) were evaluated before and after treatment, and the curative effect in the two groups was  compared based on curative effect evaluation.

Results: In both groups, post-treatment values of RF, CRP and ESR were lower than the corresponding pre-treatment levels, but were significantly smaller in study group (p < 0.05). The DAS28 and VAS scores of the two groups  after treatment were significantly lower (p < 0.05) than the pretreatment levels, but the DAS28 and VAS scores were significantly lower in  study group (p < 0.05). Treatment efficacy in study group (95.0 %) was significantly higher than in control patients (77.5 %, p = 0.0476). The  results of imaging indicators showed significantly reduced post-treatment synovial thickness and joint effusion in study group  patients when compared with control patients (p < 0.01).

Conclusion: Individualized treatment strategy for RA patients based on imaging  results enhances curative effectiveness, reduces disease activity, relieves pain, and improves the quality of life of patients.
A qualitative study on factors that influence the degree of comfort experienced by patients undergoing respiratory endoscopy in combination with intravenous injections of remimazolam besylate and fentanyl
Authors: Yang Chaojuan , Kong Chengying , Jin Leying , Yang Li , Peng Danmeng , Jiang Tao
Published: February 2024

Purpose: To investigate the level of discomfort in patients undergoing respiratory endoscopy in order to provide experimental evidence  for the formulation of a comfort assessment scale for this procedure, and for guiding future research and intervention measures.

Methods: Using the phenomenological research method of qualitative research, semi-structured interviews were conducted with 18  patients who underwent respiratory endoscopy in the Respiratory Intervention Center of the Fourth Affiliated Hospital of Zhejiang  University School of Medicine. The interview data were analyzed, and the theme was extracted using the Colaizzi 7-step analysis method. During the surgery, remimazolam besylate (intravenous injection, 5 - 7.5 mg) was used in combination with fentanyl (intravenous  injection, 1 - 2 µg/kg) for flexible bronchoscopy examination.

Results: From the interview data, 3 themes and 9 sub-themes that affect the  comfort of patients undergoing respiratory endoscopic surgery were identified. These comprised individual factors (fear and worry  about the outcome), family factors (family financial difficulties and lack of care from family), and medical care factors (attitude of medical  caregivers, insufficient health education, unreasonable operation arrangements, inconvenient care, and surgical complications).  

Conclusion: Patients undergoing respiratory endoscopy experience a higher degree of comfort when remimazolam besylate is used in  combination with fentanyl. Medical staff should correctly identify the sources of discomfort in patients undergoing respiratory endoscopy  under general anesthesia, and provide targeted interventions to improve the comfort experienced. Moreover, the quality of  service provided by medical staff should be improved.
MiR-25 enhances the proliferation, invasion and migration of nasopharyngeal carcinoma cells through targeted regulation of RAGE expression
Authors: Jing Yang , Zhao Qingxia , Wang Yujuan , Lin Pei
Published: February 2024

Purpose: To determine the effect of microRNA-25 (miR-25) on the proliferation, invasion, and migration of nasopharyngeal carcinoma  cells, and the involvement of targeted regulation of late glycation end product receptor (RAGE) in the process.Methods: Three groups of cells comprising; routinely cultured nasopharyngeal normal epithelial cell line NP69 without any treatment  (blank control group), untreated human nasopharyngeal carcinoma cell line 5-8F, also cultured routinely (nasopharyngeal carcinoma  group) and 5-8F human nasopharyngeal carcinoma cells infected with lentiviral vectors for miR-25 gene knockdown and cultured after  stable transduction (miR-25 knockdown group). Cell proliferation was assessed using CCK-8 assay, while Western blot assay and  quantitative polymerase chain reaction (qPCR) were used to measure protein and mRNA expression levels of relevant genes. Transwell  assay was utilized to evaluate cell migration and invasion.Results: The miR-25 expression level was significantly increased in nasopharyngeal carcinoma group (p < 0.05). Cell proliferation,  migration, and invasion rates in miR-25 knockdown group were lower than those in nasopharyngeal carcinoma group (p < 0.05).  Apoptosis rate of cells and levels of apoptotic proteins were significantly elevated, whereas bcl-2 level was significantly reduced in miR-25  knockdown group when compared to nasopharyngeal carcinoma group (p < 0.05). Protein expression levels of RAGE and S100P was  significantly increased in nasopharyngeal carcinoma group, but significantly down-regulated in miR-25 knockdown group (p < 0.05).  Conclusion: Expression of miR-25 increases in nasopharyngeal carcinoma cells. Suppression of miR25 results in decreased viability of  nasopharyngeal carcinoma cells and inhibits cell proliferation, migration, and invasion, while enhancing apoptosis. The mechanism  underlying these effects was associated with modulation of protein expressions of RAGE and S100P. Targeted regulation of late glycation  end-product receptors hold promising potential as prospective biomarker for therapeutic interventions targeting specific cancers.
Stress response and safety of lidocaine combined with dexmedetomidine in patients undergoing laparoscopic hysterectomy
Authors: Zhang Jiao , Chen Jun
Published: February 2024

Purpose: To investigate the anesthetic effect and safety issues when lidocaine is combined with dexmedetomidine in laparoscopic hysterectomy.

Methods: The data for 100 patients from the Anesthesiology Department of Changzhou Second People's Hospital Affiliated to Nanjing  Medical University who underwent laparoscopic total hysterectomy were randomly but equally divided into a control group and a  combination group. Lidocaine hydrochloride was administered by infusion in the control group, while dexmedetomidine and lidocaine  were administered together in the combination group. Inflammatory factors and stress hormone levels before and after the operation, as  well as the incidence of adverse reactions following the operation, hemodynamic index, visual pain simulation (VAS) score, and  sedation score at various times after the operation were evaluated in the two groups. Furthermore, the incidence of postoperative adverse reactions were also recorded and compared between the two groups.

Results: The combination group's recovery time was  significantly longer than that of the control group (p < 0.05). At the point of extubation and 10 min after, mean arterial pressure (MAP)  and heart rate (HR) in the combination group were significantly lower than those of the control group, respectively (p < 0.05), while the  combination group's VAS and Ramsay scores were statistically lower than those of the control group at 30 min, 24 h, and 48 h following  surgery, respectively (p < 0.05). The incidence of nausea and vomiting in the combination group was significantly lower than that in the  control group (28.0% vs 58.0%, p < 0.05).

Conclusion: Lidocaine and dexmedetomidine, when combined, enhance hemodynamics,  postoperative analgesia, and sedation in laparoscopic hysterectomy patients. The combination also lowers inflammatory stress and  stress hormone levels, as well as the risk of nausea and vomiting, leading to better safety in the patients. However, multicenter trials are  recommended to validate these findings prior to its use clinical practice.
Investigation of the efficacy of beta-blockers and reninangiotensin-aldosterone system inhibitors in chronic heart failure with preserved ejection fraction
Authors: Zhao Di , Bu Yanling , Guo Jiarui , Huo Yanping , Zhang Na , Shao Haifeng
Published: February 2024

Purpose: To investigate the clinical effectiveness of beta-blockers (BBs) and renin-angiotensinaldosterone system (RAAS) inhibitors in chronic heart failure with preserved ejection fraction (HFpEF).

Methods: 100 patients with HFpEF admitted to The Third Affiliated Hospital of Qiqihar Medical University, China, between April and June  2023 were stratified into five groups. Beta-blocker (BB) group received bisoprolol, angiotensin-converting enzyme inhibitor (ACEI) group  received benazepril hydrochloride, angiotensin II receptor blocker (ARB) group received candesartan, angiotensin receptor neprilysin  inhibitor (ARNI) group received sacubitril valsartan, and mineralocorticoid receptor antagonist (MRA) group received spironolactone.  Differences in clinical effectiveness, six-minute walking distance (6MWD), cardiac functionality, quality of life, and survival rate were  compared among the groups.

Results: Beta-blocker group showed the highest efficacy. After treatment, all groups except MRA showed  significant improvement in 6MWD. Also, ACEI, ARB, and ARNI groups exhibited significantly longer 6 MWD than MRA group (p < 0.05). Left  ventricular ejection fraction levels showed significant improvement in the ACEI, ARNI, and MRA groups (p < 0.05), while pulmonary  artery pressure (PAP) decreased in the BB, ACEI, ARNI, and MRA groups (p < 0.05). After treatment, the Minnesota Living with Heart  Failure Questionnaire (MLHFQ) scores of BB, ACEI, ARB, and ARNI groups were significantly lower than before treatment (p < 0.05). All five  groups significantly exhibited decline in NTproBNP levels after treatment (p < 0.05). However, at 18-month follow-up, there was no  significant difference in survival rates among the groups (p > 0.05).

Conclusion: Beta-blockers (BBs) and RAAS inhibitors show promising  activity in HFpEF, bisoprolol enhances cardiac function, benazepril improves symptoms, candesartan aids exercise and sacubitril valsartan  elevates cardiac class. However, none of these drugs significantly improves clinical outcomes.
Impact of nutritional intervention on concurrent chemoradiotherapy outcomes in locally advanced esophageal cancer: A pharmacological perspective
Authors: Liu Jie , Lu Hong , Wang Pei , Zhao Yuexin , Gu Xin , Zuo Yaqin , Yu Dahai
Published: February 2024

Purpose: To determine the pharmacological implications of nutritional intervention and the occurrence of toxic side effects in patients  with locally advanced esophageal cancer undergoing concurrent chemoradiotherapy.

Methods: An extensive retrospective analysis of  clinical data was carried out on individuals who received concurrent chemo-radiotherapy. 150 patients were included in the study, with 85  patients receiving nutritional management (intervention group) and 65 patients without nutritional support (control group).  Assessments were conducted for Nutritional Risk Screening-2002 (NRS-2002) and patient-generated subjective global assessment (PG- SGA) scores, serum nutritional parameters, toxic side effects and treatment completion rates at 2, 4, and 6 weeks before and during  chemo-radiotherapy.

Results: After concurrent chemo-radiotherapy, intervention group exhibited significantly lower NRS2002 and PG- SGA scores compared to control group (p = 0.002 and 0.001, respectively). Intervention group had a statistically significant increase in  PALB (p = 0.001) and ALB, while control group experienced a significant decline in ALB (albumin) and PALB (pre-albumin) levels. Grip  strength also significantly decreased in control group compared to intervention group (p = 0.003). Intervention group showed a  significantly lower incidence of radiation esophagitis. Moreover, a smaller proportion of patients in intervention group experienced  interruptions or delays in radiotherapy compared to control group (95 % vs. 83.3 %).

Conclusion: Nutritional intervention has a  pharmacological impact on maintaining nutritional status, reducing treatment toxicities and improving the completion rates of chemo- radiotherapy in patients with locally advanced esophageal cancer. Further investigations and longer-term studies are warranted to shed  more light on the potential impact of nutritional interventions on the overall survival rates of these patients
Honokiol inhibits gallbladder cancer proliferation and epithelial mesenchymal transformation by suppressing TMPRSS4-induced PI3K/AKT activation
Authors: Lin Conglin , Wang Congren , Li Mingzhu , Cai Zhibing
Published: February 2024

Purpose: To determine the role of TMPRSS4 in gallbladder cancer (GBC).

Methods: Quantitative reverse-transcription-polymerase chain reaction (qRT-PCR) and western blotting were used to evaluate the  expression of genes, while CCK-8 kit and foci formation assay were used to assess cell growth in GBC-SD and non-obliterative zone (NOZ)  cell lines. Cell apoptosis was evaluated by flow cytometry, while cell migration and cell invasion were determined by Transwell assay in GBCSD and NOZ cell lines.

Results: TMPRSS4 was highly expressed in GBC cells, compared to normal cell, HIBEC. Overexpression of TMPRSS4 enhanced cell viability  and 2D foci formation in GBC-SD (stratified) and NOZ; however, knockdown of TMPRSS4 reduced cell proliferation and colony formation  in the cell lines (p < 0.05). TMPRSS4 deficiency increased cell apoptosis but its reinforced expression decreased cell apoptosis in GBC cell  lines (p < 0.05). Moreover, TMPRSS4 positively regulated cell invasion and migration in GBC cells by upregulating TWIST1, vimentin and N- cadherin. TMPRSS4 also regulated the activation of PI3K/AKT signal pathway. Furthermore, honokiol inhibited gallbladder cancer  proliferation and migration, and induced cell apoptosis by suppressing TMPRSS4-induced PI3K/AKT activation (p < 0.05).

Conclusion:  TMPRSS4 plays an important role in regulating cell growth, apoptosis and metastasis of gallbladder cancer cells (GBC). Thus, TMPRSS4  might be a new biomarker in gallbladder cancer.
Enhancement of the antitumor effect of cisplatin and ginsenoside Rg3 by encapsulation in polylactic-co-glycolic acid nanoparticles
Authors: Xu Wen , Zhang Qingping , Sun Leiming
Published: February 2024

Purpose: To develop dual-loaded polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) with two chemotherapeutic agents, i.e., cisplatin (DDP) and 20(R)-ginsenoside Rg3(Rg3), and to evaluate the drug release profiles and synergistic inhibitory effects of the nanoparticles on lung cancer A549 cells.Methods: The dual-laden PLGA NPs were synthesized using modified emulsion and solvent vaporization procedures. Drug loading (DL) and efficacy of co-encapsulation (EE) were determined with a modification of column elution technique. The cytotoxic and inhibitory effects of individual and combined drugs on A549 lung cancer cells were evaluated using MTT assay.Results: A sustained pattern of drug release was shown by PLGA/DDP, PLGA/Rg3, and PLGA/DDP+Rg3. The formulated PLGA and unbound drugs exerted dose- and time-reliant cytotoxic effects on A549 cells. At all concentrations tested, drugs encapsulated in PLGA nanoparticles were more effective in killing the cells than the free drugs (p < 0.05). In particular, PLGA/DDP + Rg3 formulation produced a synergistic inhibitory effect on the proliferation of A549 cells.Conclusion: Single- and dual-load PLGA groups display variabilities in profiles of drug release and in vitro cytotoxic effect. Furthermore, dual-load PLGA group produces significantly enhanced treatment effect. These results suggest that PLGA formulations hold great potential for future drug delivery.
Catalpol attenuates EMT by inhibiting Wnt/β-catenin and TGF-β/Smads signaling to alleviate kidney fibrosis
Authors: Gao Hong-yan , Ruan Tao-ren , Xing Mao , Chen Yi , Bai Shu-tong , Liu Jin-kun , Yu Xiao-wen , Feng Jing , Xu Xiao-yu , Wang Qin
Published: February 2024

Purpose: To determine the anti-fibrosis effect and underlying mechanism of action of catalpol (CAT) in chronic kidney disease (CKD).

Methods: Forty (40) rats were randomly divided into a sham group (10 rats) and a unilateral ureteral obstruction (UUO) model group (30  rats) which was further randomly subdivided into three groups of ten (10) rats each: the UUO model group, UUO + CAT low-dose group,  and UUO + CAT high-dose group. HK-2 cells were stimulated with TGF-β1 for in vitro studies. Renal injury and fibrotic lesions were determined by H&E and Masson’s staining. Key proteins of TGF-β/Smads and Wnt/β-catenin signaling pathways involved in epithelial- mesenchymal transition (EMT) were determined by immunohistochemistry, immunofluorescence staining and Western blotting.

Results: Catalpol downregulated the expression of α-SMA (p < 0.05) and upregulated the expression of E-cadherin (p < 0.05) stimulated  by TGF-β1 and LiCl in HK-2 cells, which is consistent with the role of DKK1 in vitro. CAT ameliorated renal fibrosis and repressed the  expression of key proteins of TGFβ/Smads and Wnt/β-catenin pathways in UUO rats.

Conclusion: Catalpol inhibits EMT and alleviates  kidney fibrosis by suppressing the hyperactivation of TGF-β/Smad and Wnt/β-catenin signaling pathways. Therefore, CAT is a promising  therapeutic drug for renal fibrosis.
Mediating Effect of Tourists’ Feedback Information on the Relationship between Interaction and Service Innovation in Tanzania
Authors: Busagara Theresia , Mori Neema , Jan Dev
Published: February 2024

Studies on feedback information and interactions among tourists and tourism services are limited to residents, service providers, and mostly business-to-business. Little remains unknown about the relevance of tourists’ feedback information and interactions to service innovation. This study examined the mediating effect of tourist feedback information in the relationship between tourists’ interactions and service innovation. A survey of 290 Tanzanian tourism firms gathered the scale data that was analysed using Structural Equation Modelling in the Partial Least Square method. Tourist feedback information and tourists’ interactions were found to positively affect service innovation. While tourists’ interactions exhibited a strong positive effect on service innovation, there is a partial mediation of feedback information between the two. These results inform the service industry to capitalize on customer feedback information in enriching new service designs. As a result, practitioners in service firms are at a high point to set strategies to improve interactions as good practices in service innovation. Specifically, the tourism industry actors obtain insights into handling customers and benefiting from their actions and information. Theoretically, the study offers an understanding of interactions as applied in the service dominant logic such that apart from the exchange focus, feedback and interactions can also be considered as information sources for service innovation across firms. These results suggest that tourist interactions and feedback should be treated as key information points for enabling service innovation.
understanding of the concept of knowledge management for knowledge management system implementation in two mobile telecommunication companies in Namibia
Authors: Mitchell Mubuyaeta Mishake , Msafiri Ponera Jaffar
Published: February 2024

This study investigates the understanding of knowledge management (KM) for knowledge management systems (KMS) implementation for efficient KM practice in two mobile telecommunications (MT) companies in Namibia. Using a mixed-methods approach, the study employed convergent parallel design via parallel sampling techniques to gather insights. Three hundred and twenty-nine questionnaires were disseminated via online surveys using simple random sampling from 1,584 employees. The questionnaires returned were then accepted based on the comprehension of KM concepts for KMS implementation to introduce KM practice. Quantitative data was subjected to descriptive analysis using SPSS. Qualitative data underwent thematic analysis using Atlas TI. The findings of this study show that Namibia's two MT companies stand to gain significant advantages by implementing KM practices based on their understanding and implementation of KM. By enhancing their KM capabilities, these companies can leverage this organisational knowledge (OK) to drive innovation and adequately meet the demands of a fiercely competitive, knowledge-based society (KBS). This article is of significant value to KM scholars, professionals, decision-makers, and policymakers as an introductory guide to the comprehension of KM for KMS and how they can facilitate effective KM practices within Namibia.
Artificial Intelligence Services at Academic Libraries in Tanzania: Awareness, Adoption and Prospects
Authors: Bakiri Hussein , Mbembati Hadija , Tinabo Rose
Published: February 2024

Libraries use various information management systems for organizing, packaging, and repackaging services to mention a few. The reliability of these services is highly affected by several factors including; an increase in the number of users, limited resources, decentralized learning, and the emergence of digital resources. Bearing the benefits that AI technologies offer to libraries including cost-effective operations, improved services, and timely analyses, research to investigate the awareness and prospects have been conducted in various countries. Several studies investigated the level of adopting AI technologies for effective services in academic libraries for a particular study area. The general observation from such studies indicates that the level of AI adoption and awareness varies depending on a particular country under investigation. Therefore, due to the diversification of awareness and adoption levels from various areas, it is vital to investigate it in the Tanzanian context. This study aims to investigate the level of awareness and prospects of AI adoption in Tanzanian academic libraries using a qualitative approach in which 36 librarians from 7 giant and widespread higher learning institutions (HLI) are interviewed. The findings reported in this study indicate that the level of awareness is high (68.3%) while that of adoption is low (23%). Furthermore, the findings imply that the demand and readiness for the adoption of AI among librarians is very high. Therefore, this work provides new information to librarians, HLIs’ management, and policymakers regarding the trend of artificial intelligence adoption in academic libraries. The findings reported in this paper can be used by librarians and management to align their plans toward AI adoption for effective and better service delivery.
Information needs and sources used by small-scale horticulture farmers in Morogoro urban, Tanzania
Authors: Masele Juma James
Published: February 2024

While the role of information in improving small-scale horticultural farming in urban areas is widely acknowledged in the literature, its potential cannot be realized unless the information needs that enlighten the stakeholders about the appropriate information sources are known.  This is because horticultural farming is an information intensive endeavour and it is full of uncertainties. This study investigated information needs and the sources used by small-scale horticulture farmers in Morogoro Urban in Tanzania. A mixed-method research design was used to collect data from 133 respondents. Questionnaires, observation, and interviews were used in the data collection process. Descriptive analysis was used inanalysing quantitative data, while content analysis was used for qualitative data. The findings of the study show that farmers needed information on sowing/harvesting time, disease and pest control, erosion control, harvest storage, and produce markets. Friends/colleagues ranked as important information sources, followed by extension officers, libraries, Internet, colleagues, cooperatives, Nanenane exhibitions, radio, and newspapers. The challenges faced including the unavailability of extension officers, and long distances to/from libraries were mentioned as significant factors hindering farmers’ use of small-scale horticultural farming information and horticultural development in general. Recommendations have been provided that, equip small-scale horticultural crop farmers with up-to-date knowledge and skills to shape the farmers' thinking, knowledge, and attitude. Such awareness will add value to the information exchanged through interpersonal relationships.  Employing more skilled extension officers and the use of modern ICT to improve horticulture farmers’ information access is also recommended.
Harmoni Alam dan Spiritualitas: Studi Kepercayaan Orang Manggarai Timur terhadap Roh Alam
Authors: Gole Hendrikus , Sudhiarsa Raymundus I Made
Published: February 2024

The focus of this study discusses natural damage as negative changes in the natural environment, especially as a result of human activities. Air, water, and soil pollution, as well as climate change are the main elements that contribute to the destruction of nature, threaten the sustainability of ecosystems and cause biodiversity loss with negative impacts on human health. This study aims to explore the belief of Manggarai people in nature spirits. In their belief, nature spirits are considered the guardians of the balance of the ecosystem, and every element of nature is inhabited by spirits possessing spiritual power. The destruction of nature is seen as a disturbance to the spirit of nature, creating disharmony in the ecosystem and the potential for natural disasters. The study highlights the importance of not only maintaining physical ecosystems but also maintaining spiritual balance with the spirits of nature. This study uses literature methods sourced from books and scientific articles that are in accordance with this discourse. The results of this study provide deep insight into the belief system of the East Manggarai people towards nature spirits. This study found that the relationship between nature and humans is the essence of human life. Man cannot live without nature. Nature becomes a container to provide life for humans.
Analisis Formulasi American Coookies Puree Kulit Pisang Kepok (Musa Paradisiaca Linn) Berdasarkan Daya Terima Konsumen
Authors: Zahrakusumah Alysha Emma , Dahlia Mutiara , Mahdiyah Mahdiyah
Published: February 2024

Kepok banana peel puree is used in making American cookies as an effort to utilize local food. The research was conducted to analyze the effect of the formulation using kepok banana peel puree in the manufacture of American cookies on consumer acceptance. This research was conducted at the Pastry and Bakery Processing Laboratory, Culinary Education Study Program, Faculty of Engineering, Jakarta State University. The method used in this research is the experimental method. The research sample was American cookies with the use of kepok banana skin puree with a percentage of 10%, 20% and 30%. Then it was tested on 25 slightly trained panelists who assessed aspects of color, aroma, taste, inner texture, outer texture, crumb, and shape. In this research, it is expected to obtain modifications of American cookies with kepok banana peel puree which are preferred and rich in fiber and can optimize the utilization of kepok banana peels as a functional local food. From the results of the Friedman test, the best treatment is the result of the kepok banana peel puree formulation as much as 20%.
Mapping of Carbon Dioxide (Co2) Emissions Due To Increased Vehicle Volume in Mataram City
Authors: Saputra Rifky Bagus
Published: February 2024

The high level of population and activities in the city of Mataram also increases the use of vehicles as a secondary need for the community to help with daily activities in land transportation. As the use of vehicles increases, the demand for fuel oil (BBM) also increases. Fuel is a material that can be converted into energy by burning fuel where the fuel contains heat energy that can be released and manipulated. Vehicle emissions are a major source of pollution in big cities in Indonesia. CO2 is a compound consisting of the elements carbon and oxygen with the writing CO2. Carbon dioxide is a gaseous element that exists at atmospheric temperature and pressure. The hope for this research is to determine CO2 levels in the city of Mataram and prevent CO2 emissions from increasing. The results of calculating the highest vehicle volume are located in segment III Jalan Majapahit of 3506 pcu/hour which occurs at 17:00 - 17:15 WITA. The results of the regression analysis between vehicle volume as the X variable and CO2 gas emissions as the Y variable on the five road segments conducted by the study were y = 134.57 ln(x) - 970.14 with an R2 value of 0.8661 included in the 0.80 interval – 1,000 which means that the strength of the relationship between vehicle volume and CO2 emissions has a very strong relationship and vehicle volume contributes 86.6165% to CO2 emissions. Based on the results of the discussion that was carried out, the CO2 gas emission levels in all road segments carried out had an average CO2 gas emission level value of 103.31 – 108.56 kg/hour.
Sara Pataanguna's Dakwah Philosophy Sultan La Ode Muhammad Idrus Qaimuddin in Realizing Peace in Buton Southeast Sulawesi
Authors: Hasim Saliudin
Published: February 2024

In his youth , Muhammad Idrus accept Islamic education from his grandfather , the sultan of La Jampi , who had also been there became sultan with the title Sultan Qaim al-Din Tua (1763-1788). He studied under Sheikh Muhammad bin Syais Sumbul Al Makki. From this scholar He accept attraction khalwatiyah Sammaniyah . There are also many Sultan Muhammad Idrus pouring work he wrote in Arabic , Javanese script and language Wolio . Sara Pataanguna is philosophy rooted life _ from values wisdom local Butonese society and in harmony with religious values in forming character superior dignified . Pinching each other skin ( Pobinci-binciki Kuli) is manifested in four mark basic . First, Pomaa-maeka (Shame through each other ) , Second Pomaa-maasiaka ( Love each other loving ), Third Popia-piara ( mutual care ), and fourth Poangka-angkataka (mutual respect ), is expected become node unifying Buton people use it realization peace , conditionality and stability society . As for types The research used in this writing is research Qualitative approach _ studies library , namely a method of collecting data by means learn theories from various literature related to research . _ There are 4 stages in research studies References that is prepare equipment necessary tools , prepare _ bibliography work , organizing time and reading or taking notes on research material .
Survey and Experimentation: Critical Review of Research Design in Social Sciences
Authors: Mayukh Nafisa , Al-Giffari Haekal Adha
Published: February 2024

This comparative critical review study delves into the utilization of survey and experimental research designs within the intricate landscape of social sciences. Through a comprehensive analysis of six articles—three for each methodology—focuses on social media's impact on self-esteem (survey) and news consumption effects (experiment). The study's comparative framework critically evaluates the alignment of research designs with objectives, robustness of methodologies, and inherent strengths and weaknesses. It demonstrates how these methodologies, though distinct, offer complementary tools for comprehending complex social phenomena Accordingly, the survey-based investigations emphasize the critical understanding of the interplay between social media use and self-esteem, particularly among the youth. Simultaneously, experimental studies unravel factors shaping news consumption patterns, holding significance for news organizations and researchers seeking to enhance audience engagement. Limitations include sample size constraints and potential bias. Nevertheless, through examination of the research designs and specific contexts, the study underscores the importance of methodological choice and its impact on outcomes. It highlights the potential of innovative techniques like the Experience Sampling Method in surveys and the importance of controlled settings in experiments. These insights further enrich the social sciences' understanding of multifaceted societal dynamics
Factor Analysis of Increasing Customer Loyalty in The Automotive Industry
Authors: Wahyuni Annisa Tri , SD Triwulandari , Fitriana Rina
Published: February 2024

This study aims to analyze the factors that influence loyalty in the automotive industry. The population of this study are car owners who live in Jabotabek . Using two types of questionnaires, namely the screening questionnaire and the main questionnaire consisting of 27 indicators. Probability sampling was used in determining the sample so that 135 samples were obtained which were dominated by Toyota and Honda brand users with the MVP segment. Factor analysis was carried out using the SEM (structural equation model) method with Smart PLS software and tested the validity, Cronbach's Alpha reliability test and goodness of fit to test the structural model. The results showed that among the 3 variables, namely brand image, product and staff, only brand image proved to have a positive and significant effect on loyalty (50.1%), while the product and staff variables had no significant effect. With the results of this study, it is hoped that ATPM can maintain the loyalty of their customers by continuing to improve their brand image by paying attention to 7 indicators, namely reliable, advanced, challenging, creative, sophisticated, luxury and sustainable.
Woman Violence in Afghanistan and The Return of Taliban in Contagious Violence Perspektive
Authors: Dasadwiastaning Valentia Nadya
Published: February 2024

This research shows that contagious violence is playing important role in spreading violence against women in Afghanistan. This research argues that it is important to pay attention on how violence expose a subject, when it happened and who ie exposed by violence at that time. It is important also to produce immunity amidst society in Afghanistan. It is important to prevent wider transmission of violence in Afghanistan. Contagious violence and immunity theory shows that Taliban is the Host of violence that needs to overcome. Taliban massively spreading violence to disrupt immune system of anti violence in Afghanistan. Hiding the prove and preventing report activity will causes horrible silent spreading of violence. This research also shows that tracing and immediate response to any violence act is needed to cut off chain of contagious violence. Finding violence cluster and directly intervene is needed to prevent the subject who already exposed becoming more violent than perpetrator. Produce immunity system and direct intervention into all cluster of violence amidst society is more effective than urging Taliban to stop violence itself.
Analysis of Digital Information Technology in Improving the Implementation of the Independent Curriculum
Authors: Muthmainnatun Inna Robbani , Hidayati Dian
Published: February 2024

technology is a innovation and development results from its creators. Digital technology delivers maximum convenience for humans to fulfill various his needs Digital technology is a system Fast counter with processing information form digital codes or values numeric. Before processing , will sensors are required to change information real become digital code. From the results of digital data processing, the information will be displayed on the screen .Implementation of the Independent Curriculum (IKM) is one of the priority programs across main units within the Ministry of Education, Culture , Research and Technology ( Kemendikbudristek ) involving the Curriculum Standards and Educational Assessment Agency (BSKAP ); Directorate General of Early Childhood Education , Basic Education and Secondary Education ( Directorate General of PAUD Dikdasmen ); Directorate General Teachers and Education Personnel ( Directorate General of GTK); as well as Directorate General ( DG ) Vocational .
The Potential of Mangrove Ecosystems as A Sustainable Ecotourism Product in The Mangrove Area of Kss Beach, Tangerang District
Authors: Halim Magharetta Putriyani , Setiawan Budi
Published: February 2024

Mangrove forests have ecological, economic, research, educational and ecotourism functions. The decline in mangrove forest land has resulted in an increase in carbon in Indonesia and the loss of habitat for various types of marine biota and natural resources. Therefore, mangrove ecotourism is one way that can have a positive impact on protecting and preserving the environment and can improve the economy of the surrounding community. One of the potentials for mangrove ecotourism that can be developed is located at KSS Beach, Tangerang Regency. This research uses qualitative research by conducting observations, interviews and distributing questionnaires to the public and visitors at KSS beach. KSS Beach fulfills four elements in ecotourism, namely the element of education, the element of understanding, the element of conservation of natural resources and the element of increasing local community income, namely having mangrove forest exploration activities, mangrove education and mangrove planting. KSS Beach has three types of mangroves, namely Avicenniaceae, Rhizophoraceae, and Sonneratiaceae which can be a processed mangrove product that has sales value among the community. Therefore, KSS Beach requires further development and assistance from the government so that it can become a mangrove ecotourism that is widely known by the community.
Determining Prospective Recipients of The Indonesia Smart Scholarship Program Using The Support Vector Machine Algorithm and Simple Additive Weighting
Authors: Wibowo Agus , Lusa Sofian
Published: February 2024

Between the period from 2018 to the first semester of 2020, a total of 2.4 million students who owned the Kartu Indonesia Pintar (Indonesia Smart Card) were at risk of not being able to access the Program Indonesia Pintar due to delays in entering recipient data, misdirected targeting, and fund disbursement obstacles. During its implementation, there were issues with inaccurate data of Kartu Indonesia Pintar recipients, resulting in the beneficiaries not being entirely targeted correctly. According to Article 12 of Minister of Education and Culture Regulation No. 10 of 2020, schools, as educational units, are assigned the responsibility of managing the Smart Indonesia Program at the school level. This includes tasks such as proposing eligible student candidates for the Program based on criteria, monitoring and assisting the smooth process of receiving the benefits, and accommodating students who hold the Kartu Indonesia Pintar (KIP). However, schools faced difficulties in obtaining the eligibility data of potential Indonesia Pintar Program recipients through the school proposal format. The objective of this research is to determine the eligibility of potential Indonesia Pintar Program recipients using a combination of Support Vector Machine (SVM) and Simple Additive Weighting (SAW) techniques. The SVM model was trained using kernel tricks and parameter selection (C and gamma) based on data sourced from the DAPODIK application of students in SMK Negeri 1 Kota Bekasi for the academic years 2020/2021 to 2022/2023, with a dataset containing 2499 rows . This dataset was used to determine the eligibility of potential Indonesia Pintar Program recipients. The SAW method was then employed to calculate scores based on the weighting of attributes possessed by the students, which were subsequently ranked from the highest score. The Linear Kernel with parameter values C=0.1 and gamma=0.1 achieved an accuracy of 88.8% during the classification of test data, using 10% of the total dataset, which amounted to 250 rows of data. The combination of SVM and SAW methods resulted in the classification of eligibility for potential Indonesia Pintar Program recipients, ranked based on their scores using the weighted assessment with the SAW method.
Analysis of The Influence of Fundamental and Macroeconomic Factors on Stock Prices in Energy Sector Companies Listed on The Indonesia Stock Exchange
Authors: Dicardo Ilham , Adam Mohamad , Widiyanti Marlina , Andriana Isni
Published: February 2024

This study aims to test and provide evidence of the influence of macro fundamental factors, namely Liquidity (CR), Solvency (DER), Profitability (ROE), Valuation (PBV), inflation, and interest rates on stock prices (PER) in energy sector companies listed on the Indonesia Stock Exchange. This study uses the purposive sampling method conducted on energy sector companies on the Indonesia Stock Exchange for the 2018-2022 period as many as 10 companies. The type of data used is quantitative data in the form of financial data sourced from annual financial statements. The analysis method used in the study was regression analysis of panel data with the Eviews 12 application tool. Based on the method tested using the Model Feasibility Test (Test F), it can be concluded that this research model is feasible to use. The results of the analysis show that Solvency (DER) affects stock prices, while Liquidity (CR), Profitability (ROE), Valuation (PBV), inflation and interest rates do not affect share prices in energy sector companies on the Indonesia Stock Exchange.