bluuebunny/crossref_metadata_2025 huggingface dataset:
PKM Pendaftaran PIRT dan Manajemen Promosi Produk Guna Peningkatan Pemasaran Industri Rumah Tangga Gula Merah di Desa Pasuruhan Kecamatan Mertoyudan Kabupaten Magelang
Authors: Dakum Dakum , Nuryani Tri , Khusna Atina , ‘Adnan Nasrulloh Akhmad , Aby Facturrohman Wimanda , Andri Ani Evi
Published: December 2022

Industri Rumah Tangga di Desa Pasuruhan berkembang cukup baik, khususnya industri olahan gula merah. Walaupun, pemasaran yang dilakukan masih secara tradisional dan juga belum memiliki legalitas PIRT dari pemerintah. Kegiatan pengabdian ini bertujuan agar mitra dapat melakukan pendaftaran PIRT dan meningkatkan pemasaran produk. Metode yang digunakan adalah penyuluhan dan pendampinan kepada mitra secara langsung di lapangan (mitra terlibat aktif dalam kegiatan). Kegiatan ini dilakukan dengan melakukan persiapan, pelaksanaan inti, penyajian hasil pengabdian, dan pelaporan pengabdian. Hasil kegiatan pengabdian ini mitra mampu memahami terkait tata cara pendaftaran PIRT dan dapat melakukan pemasaran produk secara modern (online). Kegiatan serupa dengan ini sangat penting dilakukan di kemudian hari agar dapat membantu pelaku Industri Rumah Tangga dalam melakukan pendaftaran  PIRT dan mampu melakukan pemasaran secara online.
Administration of the land cadastre system under conditions of martial law in Ukraine
Authors: Kuryltsiv Roman , Kryshenyk Nadiia
Published: December 2022

Motives: Since the Russian invasion of Ukraine, the issue of land legal relations has become of particular concern. The urgent task is to introduce the mechanism protecting the information of the State Land Cadastre from unauthorized interference by third parties, to ensure the rights of the state, physical and legal entities to enter data about objects to the cadastral system and to use this information.
Aim: The research aims to identify ways to improve the mechanism of legal regulation of the State Land Cadastre under martial law that will ensure the restructuration and functioning of the agrarian sector of the economy, facilitate recovery of the infrastructure of Ukraine, as well as provide protection of the data from unauthorized interference by third parties, and counteract raider take-over of lands.
Results: In the present research, a particular focus is made on the performance of the system of the State Land Cadastre under martial law in Ukraine which can be used as a reference point and a sample for the administrative decisions in other countries which are vulnerable to threats because of the national security.
Development of a Low-Cost Ball-on-Flat Linear Reciprocating Apparatus: Test Validation Using Ti-6Al-4V and Ti-6Al-4V/Nb2O5 Coatings
Authors: Silva T.I. , Ferreira M.O.A. , Nascimento J.P.L. , Pietro L.R. , Neto L.A.R. Cintra , Moreira H.C. , Pereira L.V. , Leite N.B. , Gelamo R.V. , Moreto J. A.
Published: December 2022

Abstract: This work aims to propose the development of a low-cost ball-on-flat linear reciprocating apparatus that can have the same attributes of extremely expensive equipment available on the market. For this purpose, the device was constructed following the recommendations of the ASTM G133 standard. The device’s validation was performed trough a comparative study between the ASTM G133 standard and 3D profilometry technique by using Ti-6Al-4V and Ti-6Al-4V/Nb2O5 specimens. The results obtained in the present work were very motivating by showing it was possible to obtain the wear properties with reproducibility through the equipment constructed. The wear tests showed that the functionalization of the Ti-6Al-4V alloy with Nb2O5 coatings increased the wear resistance of the biomaterial, reducing the wear volume about 80.1 % when compared to the base material. Finally, this work demonstrated (i) the effectiveness and reproducibility of the device built to carry out microwear tests, (ii) the increase in resistance to the mechanical wear process conferred by the Nb2O5 film on the Ti-6Al-4V alloy and (iii) the powerful impact of the 3D profilometry technique when compared to the ASTM G133 standard for wear volume determination.
Specificity and development of distribution strategies of luxury fashion brands
Authors:   Faculty of Economics and Business, University of Zagreb, Croatia, Matić Leona , Pandža Bajs Irena ,   Faculty of Economics and Business, University of Zagreb, Croatia
Published: December 2022

The market of luxurious fashion brands is a challenging business area. It usually needs the right marketing strategy for its management. Luxury fashion brands face the challenge of how to balance the wider distribution, while at the same time confirming the peculiarity of their offer. The aim of this study is to analyse the specificity of luxury fashion brand distribution and its role in creating luxury fashion brand value. The specificity of physical and digital channels of luxury fashion brands distribution was analysed. The hypothesis was that luxury could be hardly emitted through digital distribution channels. By analysing the relevant literature and case studies, it was realised that in the market of luxury fashion brands there are exceptions to the strict rules established from the very beginnings of the luxury fashion industry. The distribution of brands with a long tradition and successful business results like Louis Vuitton, Hermes and Chanel were analysed. Luxury fashion brands successfully resist technological development by nurturing the tradition of exclusivity and unavailability. These can be marketed to some extent through digital distribution channels. The omnichannel distribution of luxury fashion brands is highly valued among the younger population. It gains greater market potential and therefore greater revenue.
SEBUAH STUDI KASUS KEBUTUHAN PSIKOSOSIAL DENGAN MASALAH KETIDAKBERDAYAAN PADA PASIEN PPOK
Authors: Yagi Jois Katrin , Agustine Uly , Boa Grasiana Florida
Published: December 2022

Pendahuluan

: PPOK adalah gangguan pada paru-paru yang dapat menyebabkan sumbatan pada saluran pernapasan. Meningkatnya angka terjadinya penyakit ini sangat mempengaruhi psikososial penderitanya, hal ini disebabkan karena program pengobatan yang kompleks atau jangka panjang yang dapat menimbulkan masalah ketidakberdayaan. Peran perawat dalam memenuhi kebutuhan Psikososial pasien perlu diterapkan sehingga penulis berencana untuk melakukan pendekatan dengan melakukan proses keperawatan kepada Pasien PPOK dengan masalah keperawatan yaitu Ketidakberdayaan. Tujuan dilakukannya penelitian ini adalah untuk mendapatkan bagaimana gambaran mengenai tindakan proses keperawatan pada pasien jiwa dengan  pasien PPOK dalam pemenuhan kebutuhan Psikososial dalam hal ini masalah Ketidakberdayaan. Metode pengumpulan data yang digunakan  dalam melakukan studi kasus dengan jumlah responden 1 pasien  adalah wawancara, observasi dan pemeriksaan fisik. Hasil: pengkajian yang didapat pada pasien Ny. R. usia 77 tahun mengatakan pasien merasa bosan saat dirawat di Rumah Sakit, dengan data objektif menunjukkan TD: 160/90 mmHg, N: 90x/menit, S: 36,6˚c dan RR: 24x/menit, pasien merasa putus asa, ADL pasien dibantu oleh keluarga, pasien tampak mengeluh dengan kondisi yang dialami, pasien terlihat gelisah dan menolak tindakan medis yang  diberikan. Diagnosa yang ditegakkan adalah Ketidakberdayaan berhubungan dengan program perawatan/pengobatan yang kompleks atau jangka panjang. 3 hari dilakukan asuhan keperawatan hasil evaluasi yaitu ADL pasien dibantu oleh keluarga, pasien tampak tenang, pasien menerima tindakan medis yang diberikan, dan pasien ditemani oleh anak-anaknya. Kesimpulan: Setelah pasien mendapatkan tindakan keperawatan selama 3 hari, masalah ketidakberdayaan yang dialami pasien Ny. R sudah teratasi. Saran: asuhan keperawatan yang dilakukan di RS tidak hanya secara fisik namun harus secara holistik, dan juga melibatkan keluarga
PENGGUNAAN ALAT PELINDUNG DIRI DI RUMAH SAKIT DI INDONESIA
Authors: Iskandar Rahayu , Samauna Desy Pratiwi
Published: December 2022

Latar Belakang Alat pelindung diri (APD) merupakan perlengkapan yang wajib digunakan pekerja saat melakukan pekerjaan yang beresiko mengganggu keselamatan dan kesehatan. Hasil survei WHO (2011) didapatkan prevalensi kejadian HAI di negara-negara berpenghasilan tinggi berkisar antara 3,5%-12%, sedangkan di negara-negara berkembang berkisar antara 5,7%-19,1%. Terdapat banyak faktor yang memengaruhi perilaku dan kepatuhan perawat dalam menggunakan APD, diantaranya pengetahuan, motivasi, ketersediaan APD, beban kerja, dan lama kerja. Tujuan dari literatur review ini adalah mengidentifikasi dan menjelaskan faktor-faktor yang memengaruhi penggunaan APD oleh perawat di rumah sakit di seluruh Indonesia. Metode penelitian menggunakan literature review dengan menggunakan 15 literatur yang direview berdasarkan hasil seleksi menggunakan PICOS framework sesuai dengan tujuan penelitian. Hasil penelitian menunjukkan mayoritas responden berada direntan usia 20-35 tahun, mayoritas berjenis kelamin perempuan, mayoritas pendidikan responden D3 Keperawatan, dan mayoritas lama kerja responden berada dalam rentang 0-10 tahun. Penggunaan APD oleh perawat di rumah sakit dipengaruhi 17 faktor yang terbagi dalam 3 domain yaitu, pengetauan, ruang lingkup pengalaman, dan karakteristik individu. Dari 15 artikel yang tereview, terdapat 3 faktor yang memengaruhi penggunaan APD perawat di rumah sakit. Kesimpulan: Penggunaan APD oleh perawat mayoritas dipengaruhi oleh faktor pengetahuan, pengawasan, dan motivasi.
Al-Ghazali's Concept of Happiness in The Alchemy of Happiness
Authors: Achmad Khudori Soleh
Published: December 2022

Al-Ghazali's book entitled The Alchemy of Happiness describes happiness. It often becomes a reference of behavior of mysticism and psychology, especially Islamic psychology. However, there are no studies that specifically examine this book. This study analyzes al-Ghazali's concept of happiness in The Alchemy of Happiness. The research data sources consist of literature having The Alchemy of Happiness as their main references. The researcher uses the content analysis method to analyze the data. The research results show that (1) Al-Ghazali's concept of happiness refers to the Qur'an, Hadīths, Islamic philosophy, Sufism teachings, and al-Farabi’s leadership concept. (2) Al-Ghazali's principle of happiness is twofold: that happiness must be pursued and tiered. Al-Ghazali's concept of happiness consists of four aspects: appetence, reason, heart, and love for Allah. (3) Furthermore, the method of achieving happiness has three stages, (1) recognizing the nature and character of the self, (2) placing the heart as the leader of the self, and (3) contemplation of God. Al-Ghazali's concept of happiness has several advantages, namely use many Quarnic references; does not eliminate the potential for lust; and does not teach fatalism. In fact, he motivates people to pursue their happiness.

Keywords: Al-Ghazali, Alchemy of Happiness, Concept of happiness, aspects of happiness, Methods of achieving happiness
Islam and Nationalism in the Thought of Jamal Al-Din Al-Afghani
Authors: Azlan Ariff Aizuddin
Published: December 2022

The dynamic of nationalism’s theoretical position has facilitated the unfolding complexities throughout history; and it still triggers an intellectual debate among the contemporary scholars. Carved out as a formidable socio-political force, nationalism today stands out as a substantial brand of resistance that defies all odds. This study has employed the qualitative method of analysis to build a framework to explore the ideas and thoughts of Jamal al-Din al-Afghani pertaining to the concepts of Islam and nationalism. Furthermore, this study argued that Afghani’s conception of Islam and nationalism was an effective tool in balancing the principles of modernity. In similar vein, Afghani’s core ideas and its underlying values suggested some different trajectories of fundamental synthesis of the nationalism and Islam. To elucidate further, Islam is viewed as a dominant force that perpetuated the development of Afghani’s comprehension on nationalism. This study culminates that Afghani’s concept of nationalism is the fundamental source of social unity that has consolidated the backbone of Islamic movement within the framework of Pan-Islamism by emphasizing the concept of unity and ummah.

Keywords: Jamal al-Din al-Afghani, Nationalism, Pan-Islamism, Social-unity, Western thought
Islamic Principles to Combat Radicalization in Academia: An Exploratory Study in Pakistani Context
Authors: Samina Batool Shah  , Riaz Ahmad Saeed
Published: December 2022

Pakistan’s geopolitical location and events like the Afghan Jihād, 9/11, and the War on Terror have adversely affected our social, religious, and geopolitical realms. Numerous perpetrators are engaged in violent extremism due to their exclusive interpretations of Islamic injunctions, which mainly deviate from the basic Islamic principles. These developments in our region have given rise to the phenomenon of radicalization in the socio-religious and political spheres. Unfortunately, this radicalization has infused the higher education sector and threatened Pakistan’s security and safety. According to this study, ‘radicalization’ is a process in which people or groups adopt extreme social, religious, and political views to discredit or reject others’ coexisting and contemporary ideologies. The status quo, the delicate law & order situation, and developing trends and ideas at the societal level further lead to polarization and division. This paper aims to identify numerous adherents’of radicalization in Higher Education Institutions (HEIs). It also explains the central concept of theological radicalization and how genuine Islamic principles combat these misconceptions. Analytical and exploratory research methodology has been adopted for this study. This research concludes that by adopting the Islamic principles of Waṣatīyyah (Moderation and the Middle Path) and ‘Ilm-al-Eḥsān (to do beautiful things or Excellence) one could lead a successful life as ordained by Allah. A reversal of the rise of radicalism and extremism is possible with the help of moderates and reformers in society and academia to incorporate Islamic socio-religious norms and values. This paper recommends that academia and society must adopt moderation, diversity, and pluralism grounded in Islamic teaching to curb radicalism. Keywords: Combating radicalization, Islamic principles, Pakistani academia, Religious modesty
MODEL KEPEMIMPINAN SPIRITUAL DAN KUALITAS SUMBER DAYA PENDIDIK
Authors: Minarti Sri
Published: December 2022

This paper focuses on the spiritual leadership model, the principal of model is motivating, sharing, loving, being an example, and being a learner, in the end, it is expected to be able to improve the quality of educator resources (teachers) to be productive and learners. To understand the phenomenon of the principal's leadership model, with a qualitative approach of case study type, and interactive data analysis as suggested by Miles and Hubemann. This study concludes that the spiritual leadership model is able to foster a spirit of achievement, hard work, tenacity and minimize laziness and open insight to not easily complain or get discouraged, because of the growing awareness that after efforts, the final result is left to the Creator. With the awareness possessed by teachers, self-confidence and willingness to learn will grow in order to be able to present the best (productive) work in carrying out their duties.
URGENSI KISAH NABI TERHADAP PENDIDIKAN ANAK USIA DINI
Authors: Busyra Sarah , Azizah Nur
Published: December 2022

The phenomenon occurs in Indonesia is that many people have high reading interest, but have low reading power. This is due to the educational pattern since childhood which the parents did not pay attention to reading habits and also what materials were read. Based on Montessori's theory, children's fantasies must be limited, so she recommends stories based on true stories. In this study, the researchers would like to present recommendations for building reading habits by providing stories of the prophet from an early age as well as its influence on children's cognitive, emotional and spiritual development. This research uses qualitative descriptive phenomenology research. The subjects of this study were two housewives who gave stories of the prophet to their children. The results of this study indicate that the telling of the prophet's story from a child at an early age is an urgent thing for parents to do in order to form a child who is not only good in character, but also mentally and spiritually.
IMPLEMENTASI STRATEGI PEMBELAJARAN DENGAN PENDEKATAN INDEX CARD MATCH DALAM MENINGKATKAN MOTIVASI BELAJAR SISWA DI MTS NEGERI 2 SLEMAN
Authors: Hasanah Nur Zaytun , Nurafni Nurafni
Published: December 2022

In the some units of educational institutions, there are still use monotonous learning strategies, the teacher lecturing and students listening, it has an impact on students who are not enthusiastic to participating in the class. The index card match strategy is not implemented in all educational units, due to the lack of teachers in applying this method in classroom learning. In fact, with this method, it can overcome the problems that exist in the field related to the learning process.

The purpose of this study is to interpret the implementation of learning strategies with the index card match to increasing student motivation at MTS N 2 Sleman. This research is qualitative. Data collection techniques used are observation methods, documentation methods and interview methods. The data analysis technique used is Miles, Huberman and Saldana with the stages of data collection, data condensation, data presentation and drawing conclusions.

The results showed that the implementation of the learning strategy with the index card match approach was successful and successful in increasing students learning motivation at MTS N 2 Sleman. Therefore, with the index card match strategy, it will provide a new nuance for education, especially in the learning process. Learning with this strategy will make the learning atmosphere more fun and not boring.
ELECTION OF JUDGES AS A METHOD OF GIVING THEM AUTHORITIES IN THE USA AND THE NEED TO IMPLEMENT THE SYSTEM OF JUDGES’S ELECTION IN UKRAINE
Authors:   Academy of the State Penitentiary Service, Chernihiv, Ukraine, Oliinyk V.S. , Rebkalo M.M. ,   Academy of the State Penitentiary Service, Chernihiv, Ukraine
Published: December 2022

The method of empowering judges in Ukraine is defined in the article. The election system of judges on the example of the USA is analyzed. Its advantages and disadvantages, as well as the degree of necessity of introducing an election system of judges in Ukraine are identified. Three types of judge election systems have been formed in the USA, which have more disadvantages than advantages, and therefore the model of judge election does not meet the needs of the Ukrainian judicial system. Key words: judges’ election, judges’ authorities, election system of “party” judges, election system of “non-party” judges, elections for extension of powers of judges.
Analysis of single-cell RNA sequencing data revealed the upregulation of Wnt signaling pathway and potential biomarkers in Oral Squamous Cell Carcinoma cancer-associated fibroblasts
Authors: Huynh Nam Cong Nhat
Published: December 2022

CAFs (cancer-associated fibroblasts) and tumor-associated p-EMT (partial epithelial mesenchymal transition) cells coexist and contribute to the formation of epithelial tumors like OSCC (oral squamous cell carcinoma). In oral cancer, Wnt signaling pathway contributes to the tumor progression, invasion and metastasis. Here we deeply analyzed Wnt signaling pathway using our previous single-cell RNA-seq data of CAFs and p-EMT tumor cells in OSCC by computational methods.

Integrated single-cell RNA sequencing data of OSCC CAF and p-EMT clusters were obtained from our previous study. These cells were from samples being primary tumor, oral cavity location, metastasis information and then analyzed by R, Python to investigate the gene expression, cell-cell communication, gen set enrichment analysis (GSEA) and overall survival analysis across metastasis conditions regarding Wnt signaling pathway.

Genes related to Wnt signaling pathway upregulated in CAFs and p-EMT cancer cells, especially under metastasis condition including WNT2, WNT5A, FZD1-4, ROR2 in CAFs, and WNT7B, FZD2/5/6 in p-EMT cells. Cell-cell interaction analysis and GSEA in CAFs and p-EMT tumor cells highlighted non-canonical Wnt signaling pathway in CAFs and canonical Wnt signaling pathway in p-EMT tumor cells. CTHRC1 and SFRP2 were suggested as biomarkers in Wnt signaling pathway of CAFs from the gene expression, GSEA and overall survival analysis.

Our study found CTHRC1 and SFRP2 as biomarkers for HSCC and OSCC prognosis belong to CAFs of TME. It might pave the way for targetable treatment based on WNT ligand-receptor interaction and Wnt signaling modulation in OSCC CAFs based on metastatic status.
The Ways to Improve the Interaction of Banks and Fintech Companies in Ukraine Based on Foreign Experience
Authors:   Ivano-Frankivsk National Technical University of Oil and Gas, Romashko Oleksandra M. , Krykhivska Nataliia О. ,   Ivano-Frankivsk National Technical University of Oil and Gas
Published: December 2022

The article is aimed at distinguishing the main advantages of partnership between banking institutions and fintech companies and highlight the main ways to improve such interaction. Recently, the number of banks cooperating with fintech startups has been constantly increasing. An important role here was played by the introduction of modern financial technologies, which contributed to the transition of banks to the digitalization of activities. The article proposes a conceptual scheme of innovative interaction between banks and fintech companies. The purpose of this interaction is the introduction of innovative financial instruments, which will improve the quantitative and qualitative composition of banking services and provide commercial banks with competitive advantages. The main advantages of integration of banking institutions and fintech companies are distinguished, including: comfort of receiving banking services; acceleration of work speed; expansion of activities without increasing the network of branches; gradual transition from offline banking to Internet and mobile banking; reducing the bank’s expenses and increasing its economic efficiency; increase in sales; income growth; complex competitive advantages in the long run. Emphasis is placed on the fact that the result of cooperation between banks and fintech startups is to create new products and services or products and services with updated characteristics, which are represented by: innovative programs and projects; novel intellectual products; modern new technological equipment and processes; new approaches to the development and formation of the market of modern banking products and services. On the basis of foreign experience, the main innovative financial instruments in the directions of fintech have been summarized, the introduction of which into the activities of domestic banks will allow banking institutions to reach a higher level of competitiveness in the world financial markets. Prospects for further research are to distinguish the major reasons that hinder the effective implementation of digitalization trends in the activities of banking institutions.
Financial Monitoring in the Securities Market of Ukraine
Authors:   Vinnytsia Trade and Economic Institute of the State Trade and Economic University, Timoshenko Nataliia M.
Published: December 2022

The purpose of the article is to study the current status of financial monitoring carried out in the securities market of Ukraine. The article analyzes the activities of the entities of the State-based financial monitoring and primary financial monitoring in the stock market of Ukraine. Their main functions and tasks in the financial monitoring system are distinguished. Based on the carried out research, it is concluded that securities are often used in illegal schemes (withdrawal of assets outside Ukraine, minimization of tax liabilities, tax evasion, etc.) that precede the laundering of criminal income. One of the risky instruments of the financial market was also the purchase and sale of domestic government bonds. On the one hand, this type of securities can be considered one of the most reliable financial instruments due to its high liquidity and wide range of applications. At the same time, the high demand and peculiarities of execution of contracts concluded on the stock exchange for the purchase/sale of domestic government bonds make them attractive in schemes of legalization of illegal income, especially for public figures who must declare their wealth. Considering the nature of reports of violations of securities transactions, it can be concluded that there is a high proportion of possible schemes for legalizing dirty funds. Under martial law, there have been significant changes in the process of identification and verification of clients of the primary financial monitoring entities in order to simplify the purchase of government securities. Thus it is worth noting that the largest share of violations of financial legislation falls on government bonds, which have become available to various categories of investors (including individuals). This fact may contribute to the emergence of new schemes for laundering (legalization) of proceeds from crime. Therefore, the entities of the State-based financial monitoring should develop a system of hedging risks regarding the placement of government bonds among different categories of investors. This is especially true of the over-the-counter market. It is worth noting that this segment of the stock market is under the partial control of the national depository of the NBU. Therefore, it is proposed to create an entity in the securities market that would adopt the functions of controlling and preventing fraudulent and manipulative actions with securities.
Foresight as a Strategic Management Tool in the ICT Industry
Authors:   Dataart Solutions, Inc, Bannikov Valentyn B.
Published: December 2022

Foresight, as one of the most effective tools of strategic management, logically fits into the system of strategizing, which determines the relevance and actuality of the presented study. The desire to exchange traditions and management practices, along with consideration of scale, also contribute to the development of strategic management, in particular, foresight management. The purpose of the publication is to identify the essence of the available foresight studies and the possibilities of introducing their results in practice, in particular at the enterprises of the ICT industry. To achieve the purpose, general and special methods were used, such as methods of system analysis, analysis and synthesis, empirical methods of comparison and generalization, case method. The task is set as follows: studying the practice of application of foresight methodology in the ICT industry. The article considers the content and features of foresight as a tool of strategic management of enterprise development used to ensure their competitiveness. The purpose of the practical application of foresight is the implementation of strategic long-term forecasting, which is formed on the basis of expert opinions, analyses of factors, identification of stakeholders, displaying alternative trends in the development of enterprise, allowing to form development scenarios and implement the chosen strategy. Its main advantage consists in the maintenance of the provision of competitive advantages for a long time. Standard methods can also be used when conducting a foresight, the best practices and achievements of other enterprises can be implemented as well. The main steps of foresight management are substantiated. The efficiency and prospects of its application are determined. The positive and negative aspects of the application of foresight methodology in the enterprises’ projects were analyzed. The conclusions and results of the article can be of advantage in the educational-scientific process of the economic faculties of higher educational institutions. It is expedient to transfer them for practical use in the management of enterprises in order to increase their efficiency on an innovative basis.
Contemporary Issues of Stakeholder Interaction to Ensure Sustainable Development of United Territorial Communities
Authors:   Educational and Research Institute «Karazin Business School» of V. N. Karazin Kharkiv National University, Tretiak Viktoriia P. , Kulyk Dmytro Ye. ,   Educational and Research Institute «Karazin Business School» of V. N. Karazin Kharkiv National University
Published: December 2022

The article proves that improving the efficiency of the development and functioning of local self-government, the entire work of the territorial community depends not only on the available resources and potentials, but also on the efficiency of the interaction of the triangle of «business – government – community». It is defined that in the process of activity and development of the united territorial communities, the main groups of stakeholders include the business environment, namely: its owners and official representatives, public organizations, public activists, local self-government bodies, the population of the community, experts, etc. The use of a business model to manage relations with the concerned parties is an important basis for obtaining competitive advantages for the development of territories, subject to cooperation with stakeholders. Thanks to this, there will be a betterment in the socioeconomic condition of the territorial community, an increase in the overall productivity and efficiency of its activities; in general, this will contribute to the stable development of the territorial community. The coherence of the work of the participants of the territorial community, i. e., establishing consensuses and taking into account the interests of each group of stakeholders, will not interfere with the development process, will prevent the emergence of contradictions and will ensure the implementation of the concept of a socioeconomic effective territorial community. Involvement of stakeholders and further interaction with them within terms of the territory development creates the potential for the maximum positive effect of the implementation of strategies, plans and projects. Within the terms of companies, stakeholders have similar directions of action, and they may differ in the composition of groups and their main activities. The basis is the interest shown by stakeholders in the process of territory development. To do this, one needs to create a model that will take into account their interaction and interests. The developments of the International Association for Public Participation (IAR2) will allow to identify these aspects and adjust them.
Two Cases of Cataract after COVID-19 mRNA Vaccine Injection
Authors: Yoon Eunyu , Choi Jaewon , Ahn Minwon , Park Minji
Published: December 2022

Purpose: To report two cases of cataract that progressed after COVID-19 mRNA vaccination.Case summary: Two patients visited our clinic with decreased visual acuity in the left eye that began after mRNA vaccine. A 40-year-old man visited our hospital with decreased visual acuity in the left eye that developed 1 week after injection of the second dose of mRNA-1273 (Moderna ® ,Cambridge, UK). A 40-year-old woman visited our clinic with decreased visual acuity in the left eye that occurred on day 46 after the injection of the third dose of BNT162b2 (Pfizer ® , New York, NY, USA). Neither case had any relevant ophthalmic history, and there was no clear optic neuropathy or retinopathy on fundus examination. After phacoemulsification and intraocular lens implantation, the best-corrected visual acuity improved, and intraocular pressure has remained stable.Conclusions: The possibility of cataract development or progression after COVID-19 mRNA vaccine injection should be considered.
Blockade of Rabbit Cardiomyocyte Calcium Channels Restores the Activity of Enzyme-Substrate Complexes of the Respiratory Chain in a Model of Vibration-Mediated Hypoxia
Authors: Vorobieva V. V. , Levchenkova O. S. , Shabanov P. D.
Published: December 2022

The effect of nifedipine, a calcium channel blocker (CCB), at a dose of 7.5 mg/kg on the energy metabolism of rabbit cardiomyocytes was evaluated in a vibration-mediated model of cellular hypoxia (56 sessions of vibration 44 Hz, amplitude 0.5 mm). The energy metabolism of native heart mitochondria in a 30% tissue homogenate was assessed using a polarographic method, by recording the rate of oxygen uptake by mitochondria at 37°C in 1 ml of a saline incubation medium, equilibrated with atmospheric oxygen. In the animals exposed to vibration against the background of CCB, the rate of endogenous respiration (Ve) remained at the level of intact animals, with the amytal sensitivity increasing by 39% (p<0.05) and the malonate sensitivity decreasing by 40% (p<0.05). The malate oxidase activity at rest increased, and hyperactivation of the endogenous succinic acid oxidation system decreased as compared to the indices of the animals exposed to vibration without pharmacological protection. The observed results indicate the cardioprotective effect of nifedipine, which prevented the development of cardiomyocyte necrosis.
Customized chitooligosaccharide production—controlling their length via engineering of rhizobial chitin synthases and the choice of expression system
Authors: Weyer Rita , Hellmann Margareta J. , Hamer-Timmermann Stefanie N. , Singh Ratna , Moerschbacher Bruno M.
Published: December 2022

Chitooligosaccharides (COS) have attracted attention from industry and academia in various fields due to their diverse bioactivities. However, their conventional chemical production is environmentally unfriendly and in addition, defined and pure molecules are both scarce and expensive. A promising alternative is thein vivosynthesis of desired COS in microbial platforms with specific chitin synthases enabling a more sustainable production. Hence, we examined the whole cell factory approach with two well-established microorganisms—Escherichia coliandCorynebacterium glutamicum—to produce defined COS with the chitin synthase NodC fromRhizobiumsp. GRH2. Moreover, based on anin silicomodel of the synthase, two amino acids potentially relevant for COS length were identified and mutated to direct the production. Experimental validation showed the influence of the expression system, the mutations, and their combination on COS length, steering the production from originally pentamers towards tetramers or hexamers, the latter virtually pure. Possible explanations are given by molecular dynamics simulations. These findings pave the way for a better understanding of chitin synthases, thus allowing a more targeted production of defined COS. This will, in turn, at first allow better research of COS’ bioactivities, and subsequently enable sustainable large-scale production of oligomers.
Mesoporous crystalline Ti1-xSnxO2 (0 < x < 1) solid solution for a high-performance photocatalyst under visible light irradiation
Authors: Yu Wen , Geng Nankun , Han Jianming , Yu Wenjun , Peng Yiting
Published: December 2022

We report a facile and effective inorganic polycondensation combined with aerosol-spray strategy towards high-performance photocatalyst by fabricating mesoporous Ti1-xSnxO2 (0 < x < 1) solid solution. Such Ti1-xSnxO2 nanocrystals with high Sn-doped contents are self-assembled into mesoporous spheres can effectively promote visible-light harvest and high quantum yield, leading a longer lifetime of the photoelectron-hole pairs and less recombination. Such the photocatalysts enhanced photocatalytic activity for the degradation of Rhodamine B (RhB). The representative Ti0.9Sn0.1O2 and Ti0.8Sn0.2O2 compounds reach an optimum degradation of ≈50% and 70%, respectively, after 120 min irradiation under visible irradiation. The mesoporous Ti1-xSnxO2 solid solution could inhibit the recombination of electron-hole pairs, which promote reaction thermodynamics and kinetics for RhB degradation.
Premature stroke and cardiovascular risk in primary Sjögren's syndrome
Authors: Zippel Clara L. , Beider Sonja , Kramer Emelie , Konen Franz F. , Seeliger Tabea , Skripuletz Thomas , Hirsch Stefanie , Jablonka Alexandra , Witte Torsten , Sonnenschein Kristina , Ernst Diana
Published: December 2022

Introduction

Primary Sjögren's syndrome (pSS) is associated with an increased prevalence of traditional risk factors and cardiovascular diseases (CVDs). The study aimed to identify specific risk factors for CVD in pSS patients.

Methods

PSS patients with and without CVD were compared. All patients fulfilled the EULAR/ACR classification criteria. Patients with CVD presented at least one of the following manifestations: myocardial infarction, transient ischemic attacks, ischemic or hemorrhagic stroke, peripheral artery disease, coronary artery disease, and carotid plaques. Data were collected by a standardized protocol and review of medical records.

Results

61/312 (19.6%) pSS patients presented with CVD. Traditional risk factors such as hypertension, hypercholesterinemia and diabetes (p < 0.05), pSS manifestations, in particular vasculitis (p = 0.033) and Raynaud's phenomenon (p = 0.018) were associated with CVD. Among patients with ischemic events (28/312, 9%), particularly cerebrovascular disease (n = 12/28, 42.9%), correlations with increased EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) (p = 0.039) and EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI) (p = 0.048) were observed. Age at first cerebrovascular event was 55.2 [48.9–69.6] years. Multivariate analysis confirmed hypertension [odds ratio (OR) 3.7, 95% confidence interval (CI) 1.87–7.18, p < 0.001], hypercholesterinemia (OR 3.1, 95% CI 1.63–5.72, p < 0.001), male gender (OR 0.4, 95% CI 0.17–0.78, p = 0.009), Raynaud's phenomenon (OR 2.5, 95% CI 1.28–4.82, p = 0.007), and CNS involvement (OR 2.7, 95% CI 1.00–7.15, p = 0.048) as independent CVD predictors.

Conclusion

Raynaud's phenomen as well as vasculitis and high ESSDAI have shown a significant association to CVD. PSS patients with cerebrovascular events were younger than expected. Knowledge about risk factors may help clinicians to identify pSS patients at risk for CVD. After diagnosis of pSS, patients should be screened for risk factors such as hypertension and receive appropriate therapy to prevent or at least reduce sequelae such as infarction. However, further investigations are necessary in order to achieve a reliable risk stratification for these patients.
Association between weight-adjusted-waist index and heart failure: Results from National Health and Nutrition Examination Survey 1999–2018
Authors: Zhang Daoliang , Shi Wenrui , Ding Zhaohui , Park Jieun , Wu Shaohui , Zhang Jian
Published: December 2022

Background

Weight-adjusted waist circumference index (WWI) is a novel index positively associated with excessive fat accumulation. The current study aims to evaluate the association between WWI and the prevalent heart failure (HF), and to assess the value of WWI to improve the detection of HF in the general population.

Methods

A total of 25,509 subjects from National Health and Nutrition Examination Survey 1999–2018 were included into our study. WWI was calculated as WC (cm) divided by the square root of weight (kg). HF was identified according to the subjects’ reports.

Results

The prevalence of reported HF was 2.96%. With adjustment of demographic, anthropometric, laboratory, and medical history data, one SD increment of WWI could cast an additional 19.5% risk for prevalent HF. After separating WWI into quartiles, the fourth quartile had a 1.670 times risk of prevalent HF compared to the first quartile. Furthermore, smooth curve fitting suggested that the association was linear in the entire range of WWI. Moreover, the association was robust to subgroups of age, sex, race, obesity, hypertension, and diabetes. Additionally, ROC analysis revealed a significant improvement for the detection of prevalent HF from WWI (0.890 vs. 0.894, P < 0.001); And continuous net reclassification index (0.225, P < 0.001) and integrated discrimination index (0.004, P < 0.001) also supported the improvement from WWI.

Conclusion

Our data demonstrated a significant, linear, and robust association between WWI, a simple surrogate for fat mass accumulation, and the risk for prevalent HF in a representative population. Moreover, our results also suggested the potential value of WWI to refine the detection of prevalent HF in the general population.
Association of alcohol consumption with abortion among ever-married reproductive age women in Ethiopia: A multilevel analysis
Authors: Ayana Galana Mamo , Raru Temam Beshir , Deressa Alemayehu , Regassa Lemma Demissie , Gamachu Mulugeta , Negash Belay , Birhanu Abdi , Merga Bedasa Taye
Published: December 2022

Background

A miscarriage or a spontaneous loss of a pregnancy that occurs before the 20th week is an abortion. Even though numerous recommendations state that pregnant women should abstain from alcohol at all stages of pregnancy, alcohol intake among pregnant women is common. However, there are few papers addressing the effect of alcohol use on miscarriage using nationally representative data. Moreover, the association of alcohol use with abortion and its mechanisms is not well studied in the Ethiopian region. Therefore, the objective of the current study was to estimate the association of alcohol use with abortion rates among reproductive age (15–49) women in Ethiopia.

Methods

Using the most recent findings of the Ethiopian Demographic and Health Survey (EDHS), secondary data analysis was performed among pregnant women in Ethiopia. A total of 11,396 women between the ages of 15 and 49 years who were of reproductive age were included in the research. To characterize the study population, descriptive statistics were used. The variability was considered using the multilevel binary logistic regression model. A multilevel binary logistic model was used to determine the effect of alcohol intake on abortion while controlling for potential confounders. In the multivariable analysis, variables with a P-value of less than 0.05 were considered statistically significant for the response variable.

Results

The proportion of women who had an abortion was 10.46% with a 95% CI of 9.92–11.03. In the ﬁnal model of the multilevel analysis, age group [adjusted odds ratio (AOR) = 6.13; 95% CI: 3.86–9.73], education level (AOR = 1.29; 95 and CI: 1.10–1.51), alcohol consumption (AOR = 1.38; 95% CI: 1.18–1.61), age at first sex (AOR = 1.20; 95% CI: 1.03–1.39), media exposure (AOR = 1.28, CI: 1.10–1.48), contraceptive use (AOR = 1.34, CI: 1.16–1.56), and occupation of respondent (AOR = 1.21, CI: 1.06–1.38) were identified to be significant determinants of abortion in Ethiopia.

Conclusion

Sexual and reproductive health education and family planning programs should target older women in the reproductive age group, women with primary educational status, working women, and those who initiated sexual intercourse at a younger age considering it could reduce abortion and unintended pregnancy. Furthermore, as part of sexual and reproductive health education, the adverse effect of alcohol consumption on abortion should be emphasized.
Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood
Authors: Landsem Anne , Emblem Åse , Lau Corinna , Christiansen Dorte , Gerogianni Alexandra , Karlsen Bård Ove , Mollnes Tom Eirik , Nilsson Per H. , Brekke Ole-Lars
Published: December 2022

Introduction

Platelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis-associated coagulopathy.

Methods

In this study, we investigated the role of complement inEscherichia coli(E. coli)-induced platelet aggregation in human whole blood, using Multiplate®aggregometry, flow cytometry, and confocal microscopy.

Results and Discussion

We found that compstatin, which inhibits the cleavage of complement component C3 to its components C3a and C3b, reduced theE. coli-induced platelet aggregation by 42%-76% (p = 0.0417). This C3-dependent aggregation was not C3a-mediated as neither inhibition of C3a using a blocking antibody or a C3a receptor antagonist, nor the addition of purified C3a had any effects. In contrast, a C3b-blocking antibody significantly reduced theE. coli-induced platelet aggregation by 67% (p = 0.0133). We could not detect opsonized C3b on platelets, indicating that the effect of C3 was not dependent on C3b-fragment deposition on platelets. Indeed, inhibition of glycoprotein IIb/IIIa (GPIIb/IIIa) and complement receptor 1 (CR1) showed that these receptors were involved in platelet aggregation. Furthermore, aggregation was more pronounced in hirudin whole blood than in hirudin platelet-rich plasma, indicating thatE. coli-induced platelet aggregation involved other blood cells. In conclusion, theE. coli-induced platelet aggregation in human whole blood is partly C3b-dependent, and GPIIb/IIIa and CR1 are also involved in this process.
Efficacy and safety of belimumab for the treatment of refractory childhood-onset systemic lupus erythematosus: A single-center, real-world, retrospective study
Authors: Wang Dahai , Shan Chunrong , Liu Jia , Zhang Ranran , Zhu Guohao , Gao Tingting , Chang Hong , Gao Shan , Bai Cui , Nie Nana , Zhang Qiuye , Lin Yi
Published: December 2022

Objective

This study aimed to investigate the efficacy and safety of belimumab for treating children with refractory childhood-onset systemic lupus erythematosus (cSLE).

Methods

Twenty-six cSLE patients who received belimumab treatment in our hospital from January 2020 to September 2021 (23 of them for more than 52 weeks) were enrolled in this study. Their clinical and laboratory data, assessment of disease activity, glucocorticoid dosage, and treatment-emergent adverse events (TEAEs) were retrieved for analysis. The paired samples t-test and the nonparametric test were used to compare the baseline and post-treatment data.

Results

The mean age of onset was 10.3 ± 2.4 years old; the mean disease duration was 41.6 ± 37.4 months; the median Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score was 10 (P25, P75: 3, 17); and the mean Physician’s Global Assessment (PGA) score at baseline was 1.9 ± 1.0. Compared with the baseline values, there was a significant decrease in the 24-h urine protein quantifications at 24 and 52 weeks of treatment (P<0.05) as well as an elevated complement (C) 3 and C4 levels at 4, 12, 24, and 52 weeks of treatment. In addition, the SLEDAI-2K and PGA scores as well as the percentage of CD19+ B cells were significantly decreased at 12, 24, and 52 weeks of treatment compared with the baseline values (P<0.05). The dosage of glucocorticoid at 4, 12, 24, and 52 weeks of treatment was significantly less than that at baseline or the previous follow-up (P<0.05). At 52 weeks, 14 subjects (53.8%) achieved Lupus Low Disease Activity State (LLDAS), and 4 subjects (15.4%) reached clinical remission (CR). At the last follow-up, 16 subjects (61.5%) achieved LLDAS, and 10 subjects (38.5%) reached CR.

Conclusions

Belimumab treatment can significantly improve laboratory indicators, reduce disease activity, and decrease the dosage of glucocorticoid required in children with cSLE. Moreover, it has a good safety profile.