bluuebunny/crossref_metadata_2025 huggingface dataset:
Recurrence Beyond the Milan Criteria of HBV-Related Single Hepatocellular Carcinoma of 2–3 cm: Comparison of Resection and Ablation
Authors: Chen Shuanggang , Ma Weimei , Shen Lujun , Wu Ying , Qi Han , Cao Fei , Huang Tao , Fan Weijun
Published: October 2021

Background

Comparison of patterns of early hepatocellular carcinoma (HCC) recurrence beyond the Milan criteria (HRBM) and identification of the independent risk factors of time to recurrence beyond the Milan criteria (TRBM) after resection or ablation can develop an optimal first-line treatment and provide more opportunities and waiting time for salvage transplantation.

Methods

The patterns of HRBM after first-line resection or ablation in 384 patients with single-nodule HBV-associated HCC of 2–3 cm were retrospectively analyzed by one-to-one propensity score matching (PSM) between December 2008 and December 2017. The median TRBM between the resection group and the ablation group was estimated by Kaplan–Meier curves. The Cox regression analysis and binary logistic regression were used for the identification of the independent risk factors of TRBM and the occurrence of HRBM, respectively. The abilities of HRBM and the recurrence to predict overall survival (OS) were compared by the time-dependent receiver operating characteristic curves and estimated area under the curve.

Results

Of 384 patients enrolled in our study, 260 (67.7%) received resection (resection group) and 124 (32.3%) underwent ablation (ablation group). The median TRBM in the resection group was significantly longer than that in the ablation group before PSM (median, not available vs. 101.4 months, P < 0.001) and after PSM (median, not available vs. 85.7 months, P < 0.001). Cox regression showed ablation, older age, CRP ≥1.81 mg/L, and PLT ≤80 × 109/L were the independent risk factors of TRBM. Binary logistic regression also showed that ablation, CRP ≥1.81 mg/L, and PLT ≤80 × 109/L were the independent risk factors of the occurrence of HRBM. The incidences of various phenotypes of HRBM were not significantly different between the two groups, but the incidence of HRBM at the first recurrence in the ablation group was significantly higher than that in the resection group (P < 0.05). Besides, compared with recurrence, HRBM was a better predictor of OS (P < 0.05).

Conclusions

Compared with ablation, resection should be considered as a more appropriate first-line option for patients with single-nodule HBV-associated HCC of 2–3 cm and a more promising bridge for liver transplantation in those patients.
Analysis of Clinical Characteristics and Risk Factors of Plastic Bronchitis in Children With Mycoplasma pneumoniae Pneumonia
Authors: Zhong Haiqin , Yin Rong , Zhao Ran , Jiang Kun , Sun Chao , Dong Xiaoyan
Published: October 2021

Objective: To analyze the clinical characteristics of plastic bronchitis (PB) in children with Mycoplasma pneumoniae pneumonia (MPP) in order to explore its risk factors.

Methods: A retrospective analysis was performed in MPP children receiving bronchoscopy admitted to department of respiratory medicine in Shanghai Children's Hospital from January 2018 to December 2020. According to the bronchoscopic findings, the patients were divided into PB group and non-PB group. The clinical manifestations, laboratory examination, etiology, treatment methods and outcomes of the children were analyzed. Logistic regression was used to analyze the risk factors for PB in children with MPP.

Results: A total of 296 children with MPP were enrolled in the study, including 42 (14.2%) children in the PB group and 254 (85.8%) children in the non-PB group. There was no difference in the ratios of gender, age, proportion of fever, cough, wet rales, and wheezing rales between the two groups (P > 0.05). The univariate analysis showed that there were significant differences between the PB group and the non-PB group in LDH, D-dimer, CD3+CD4+(%), CD3+CD4+/CD3+CD8+, CD3 count, CD4 count, CD8 count, complement 3, IL8, IL-1β, IL-2, IL-10 (P < 0.05). The multivariate logistic regression analysis showed that fever duration > 12 d, IL-8 > 2,721.33 pg/ml, LDH > 482 U/L and complement 3 <1.02 g/L were independent risk factors for PB in children with MPP.

Conclusions: Children with PB caused by MPP have protracted fever, a strong inflammatory response and immune function disturbance.
Prenatal Diagnosis of Holt–Oram Syndrome With a Novel Mutation of TBX5 Gene: A Case Report
Authors: He Guan-nan , Wang Xue-yan , Kang Min , Chen Xi-min , Xi Na , Zhao Jing , Chen Xi
Published: October 2021

Background: Holt–Oram syndrome (HOS) is an autosomal dominant disorder caused by mutations of TBX5 gene.

Case presentation: We report a fetus with HOS diagnosed sonographically at 23 weeks of gestation. The fetal parents are non-consanguineous. The fetus exhibited short radius and ulna, inability to supinate the hands, absence of the right thumb, and heart ventricular septal defect (VSD), while the fetal father exhibited VSD and short radius and ulna only. Fetal brother had cubitus valgus and thumb adduction, except for VSD, short radius and ulna. The pregnancy was terminated. Whole-exome sequencing (WES) revealed a novel mutation in the TBX5 (c.510+1G>A) in the fetus inherited from the father. The variant (c.510+1G>A) occurs at splice donor and may alter TBX5 gene function by impact on splicing. It was not previously reported in China.

Conclusion: Our case reported a novel mutation in TBX5, which expanded the known genetic variants associated with HOS.
Non-Invasive Remote Ischemic Preconditioning May Protect the Gastric Mucosa Against Ischemia-Reperfusion-Induced Injury Through Involvement of Glucocorticoids
Authors: Filaretova Ludmila , Komkova Olga , Sudalina Maria , Yarushkina Natalia
Published: October 2021

Remote ischemic preconditioning (RIPC) is one of the most effective approaches to attenuate tissue injury caused by severe ischemia-reperfusion (I/R). Experimental studies have demonstrated that RIPC is capable of producing a protective effect not only on heart, but also on brain, lungs, kidneys, liver, intestine, and stomach. We previously demonstrated that glucocorticoids participate in protective effect of local gastric ischemic preconditioning against I/R-induced gastric injury. In the present study we investigated whether RIPC may protect the gastric mucosa against I/R-induced injury through involvement of glucocorticoids. Anesthetized fasted Sprague Dawley male rats were exposed to prolonged gastric I/R (30 min occlusion of celiac artery followed by 3 h of reperfusion) alone or with preliminary brief RIPC (10 min non-invasive occlusion of right hind limb blood flow followed by reperfusion for 30 min). First, we investigated the effect of RIPC on I/R-induced injury by itself. Then to study the role of glucocorticoids similar experiments were carried out: 1) in rats pretreated with the inhibitor of glucocorticoid synthesis, metyrapone (30 mg/kg, i.p), and in control animals; 2) in adrenalectomized rats without or with corticosterone replacement (4 mg/kg, s.c.) and in sham-operated animals; 3) in rats pretreated with glucocorticoid receptor antagonist RU-38486 (20 mg/kg, s.c.) and in control animals. I/R induced corticosterone rise and resulted in the gastric erosion formation. RIPC significantly reduced the erosion area in control animals. Metyrapone injected shortly before RIPC caused a decrease in plasma corticosterone levels and prevented the gastroprotective effect of RIPC and, moreover, further aggravated the deleterious effect of I/R. Adrenalectomy performed 1 week before experiment created long-lasting corticosterone deficiency and had no effect on the gastroprotective effect of RIPC. Nevertheless, corticosterone replacement which mimics the corticosterone rise, similar to RIPS, significantly reduced erosion areas of gastric mucosa in adrenalectomized rats supporting the role of glucocorticoids in gastroprotection. RU-38486, which occupied glucocorticoid receptors, similar to metyrapone prevented the gastroprotective effect of RIPC and, moreover, further aggravated the deleterious effect of I/R. The results of the present study demonstrate for the first time that RIPC may protect the gastric mucosa against I/R-induced injury through involvement of glucocorticoids.
Comprehensive Treatment of Trans-Arterial Chemoembolization Plus Lenvatinib Followed by Camrelizumab for Advanced Hepatocellular Carcinoma Patients
Authors: Liu Juanfang , Li Zhen , Zhang Wenguang , Lu Huibin , Sun Zhanguo , Wang Guozheng , Han Xinwei
Published: October 2021

Aim: This study aimed to report the efficacy and safety of trans-arterial chemoembolization (TACE) plus lenvatinib and camrelizumab in patients with advanced hepatocellular carcinoma (HCC).

Methods: This retrospective study enrolled 22 patients with advanced HCC from March 2018 to December 2019. All the patients received comprehensive treatment with TACE plus lenvatinib followed by camrelizumab. Overall survival (OS) and progression-free survival (PFS) were calculated and analysed using the Kaplan-Meier method and log-rank test. Treatment response and adverse events (AEs) were also evaluated.

Results: The objective response rate (ORR) and disease control rate (DCR) for the whole cohort were 68.2 and 100% at the first month and 72.7 and 95.5% at the third month, respectively. The median OS was 24 months (95% CI, 20.323–27.677 months), and the median PFS was 11.4 months (95% CI, 8.846–13.954 months). The majority of treatment-related adverse reactions were mild or moderate, except for 4 that developed to grade 3–4 (3 reactions of grade 3, 1 reaction of grade 4). No deaths or other serious adverse reactions occurred.

Conclusion:Trans-arterial chemoembolization plus lenvatinib and camrelizumab shows good results incontrolling tumour progression and prolonging median OS in patients with advanced HCC.
Therapeutic Potential of SphK1 Inhibitors Based on Abnormal Expression of SphK1 in Inflammatory Immune Related-Diseases
Authors: Bu Yanhong , Wu Hong , Deng Ran , Wang Yan
Published: October 2021

Sphingosine kinase 1(SphK1) a key enzyme that catalyzes the conversion of sphingosine (Sph) to sphingosine 1-phosphate (S1P), so as to maintain the dynamic balance of sphingolipid-rheostat in cells and participate in cell growth and death, proliferation and migration, vasoconstriction and remodeling, inflammation and metabolism. The normal expression of SphK1 maintains the balance of physiological and pathological states, which is reflected in the regulation of inflammatory factor secretion, immune response in traditional immune cells and non-traditional immune cells, and complex signal transduction. However, abnormal SphK1 expression and activity are found in various inflammatory and immune related-diseases, such as hypertension, atherosclerosis, Alzheimer’s disease, inflammatory bowel disease and rheumatoid arthritis. In view of the therapeutic potential of regulating SphK1 and its signal, the current research is aimed at SphK1 inhibitors, such as SphK1 selective inhibitors and dual SphK1/2 inhibitor, and other compounds with inhibitory potency. This review explores the regulatory role of over-expressed SphK1 in inflammatory and immune related-diseases, and investigate the latest progress of SphK1 inhibitors and the improvement of disease or pathological state.
High-Latitude Cold Ion Outflow Inferred From the Cluster Wake Observations in the Magnetotail Lobes and the Polar Cap Region
Authors: Li Kun , André Mats , Eriksson Anders , Wei Yong , Cui Jun , Haaland Stein
Published: October 2021

Cold ions with low (a few eV) thermal energies and also often low bulk drift energies, dominate the ion population in the Earth’s magnetosphere. These ions mainly originate from the ionosphere. Here we concentrate on cold ions in the high latitude polar regions, where magnetic field lines are open and connected to the magnetotail. Outflow from the ionosphere can modify the dynamics of the magnetosphere. In-situ observations of low energy ions are challenging. In the low-density polar regions the equivalent spacecraft potential is often large compared to cold ion energies and the ions cannot reach the spacecraft. Rather, a supersonic ion flow creates an enhanced wake. The local electric field associated with this wake can be used to detect the drifting cold ions, and this wake technique can be used for statistical studies. In this paper, we review some of the key results obtained from this technique. These results help us to understand how cold ionospheric outflow varies with various conditions of solar activities and the Earth’s intrinsic magnetic field.
Transition Structure Between Coaxial Cable and Dielectric Rod Waveguide in Microwave Frequency
Authors: Li Yin , Zhou Shi-Yan , Wong Sai-Wai , Lin Jing-Yu
Published: October 2021

The dielectric waveguide in THz and millimeter circuit is widely researched. However, it is rarely researched in a microwave frequency. In this article, a dielectric rod waveguide (DRW) is proposed with low transmission loss in microwave frequency. For the purpose of impedance matching, a transition section composed of the metal-coated dielectric cavity, and a dielectric horn is presented to match the impedance between the coaxial cable and the dielectric rod waveguide. Finally, the dielectric rod waveguide and the transition section have been fabricated for experimental verification. To obtain the propagation constant of the DRW, the thru-line (TL) calibration is used in measurement. The simulation and measurement results show an effective conversion between the coaxial cable and the dielectric rod waveguide.
An Insight Into the Effect of Organic Amendments on the Transpiration Efficiency of Wheat Plant in a Sodic Duplex Soil
Authors: Wang Xiaojuan , Sale Peter , Franks Ashley , Jin Jian , Krohn Christian , Armstrong Roger , Tang Caixian
Published: October 2021

Transpiration efficiency, the shoot biomass produced per unit of transpired water, is generally considered to be a constant property for a given crop in a given environment. To determine whether deep-banded organic amendments affect the transpiration efficiency (TE) of wheat plants and to provide a possible explanation for any changes in the TE, two-column experiments were carried out under controlled environment conditions. A Sodosol soil with physically constrained subsoils and a well-structured Vertosol were subjected to treatments including a control, fertilizer nutrients alone, and fertilizer-enriched organic amendments. The addition of fertilizer-enriched organic amendments in Sodosol consistently increased the canopy TE compared to the control and inorganic fertilizer treatments. The instantaneous TE, at the leaf level, was also increased by the organic-based amendments due to greater reductions in stomatal conductance and transpiration rates during periods of moderate water-deficit stress and the subsequent recovery from this stress. Shoot nitrogen (N) status could not explain the increases in TE following the addition of organic amendments relative to inorganic amendments. The increases in canopy TE were directly associated with increases in the absolute abundance of indigenous Bacillus (R2 = 0.92, p <0), a well-known genus comprising many strains of plant beneficial rhizobacteria, in subsoil below the amendment band. In contrast, there were no differences in the canopy TE and instantaneous leaf TE between the organic and fertilizer amendments in the Vertosol with a well-structured subsoil. The positive effect of organic amendments on TE in the Sodosol should be attributed to their direct or indirect effect on improving the physical structure or biological properties of the subsoil.
Influence of Vocalized Reading Practice on English Learning and Psychological Problems of Middle School Students
Authors: Zhang Hongyan , Han Xianghua
Published: October 2021

The purpose of this study is to improve the English learning anxiety and learning effect for middle school students. From the perspective of educational psychology, the influence of vocalized reading practice on the English learning of students is studied based on the self-efficacy theory and the schema theory. To encourage the students to practice English, the study might solve the problem of insufficient opportunities by applying the artificial intelligence (AI) chat system to the oral English practice of the students. Several research hypotheses are put forward, which concern the correlation between the English learning anxiety of the students with their self-efficacy, topic familiarity, and English grades under vocalized reading practice. Then, the hypotheses are verified through a controlled trial and a questionnaire survey (QS). Afterward, the experimental and QS data are statistically analyzed and tested with a regression model. The results show that the English grades, self-efficacy, and topic familiarity of the students have been significantly improved in the experimental group after the vocalized reading practice. The significance coefficient of the regression model is P = 0.000 < 0.05, which can be used to verify the proposed hypotheses. The English grades, self-efficacy, and topic familiarity can well-predict the English learning anxiety of the students. The computer simulation in educational communication (CSIEC) teaching system and AI can help create an interactive learning environment for the students to practice oral English by chatting with AI robots.
Research on the Integration of Media Literacy Innovative Concept and Entrepreneurship Education and Digital Dynamic Creative Expression Talents
Authors: Zhang Jie , Zhang Mingming , Liu Yaqian , Lyu Ruimin , Cui Rongrong
Published: October 2021

The rapid development of digital technology has created a variety of forms of digital media. In these emerging media, with the support of high-performance computers, increasingly dynamic performance has become possible, and the public has cultivated a preference for dynamic content cognition. This study, based on the basic characteristics of visual perception to the cognition of motion form, aims to cultivate the cognitive literacy of pan-digital media with innovative concepts and entrepreneurship education and to explore the cognition and innovative expression methods of dynamic language in digital design. The research leads the static oriented morphological exploration and expression to the dynamic expression and thinking of the same concept object. The basic thinking steps for students from “static” to “dynamic” are established, and students are encouraged to use “Synesthesia,” “metaphor” and other methods to carry out a “dynamic expression” level of emotional association. In the experiment, two different ways of design expression, static and dynamic, are required to design and evolve graphics. In this study, 50 freshmen were selected as the training objects for the planning and training of design thinking and performance means. In the visual elaboration and expression of the inner emotion of the same content with innovative concept and entrepreneurship education, not only should the changes and combinations of the graphics be innovated, but the emotional characteristics of the more abstract graphics should be explored as well. The feedback data of students’ thinking and cognition differences in the two stages of expression were obtained through a questionnaire and analyzed and compared. The experimental results show that after the training, students’ ability to develop innovative concepts and entrepreneurship education through dynamic expression, consciousness and perception were significantly improved. This research also provides a new vision and specific implementation method for the future training of digital dynamic innovation expression ability and the cultivation of innovative concepts of digital media literacy and entrepreneurship education.
Psychometric Properties of the Chinese Irrational Procrastination Scale: Factor Structure and Measurement Invariance Across Gender
Authors: Shaw Amy , Zhang Jennifer J.
Published: October 2021

The present paper reports on the preliminary validation of a Chinese version of Steel’s Irrational Procrastination Scale (IPS). To this end, the nine items of the IPS were translated into Chinese and data were collected from a sample of 2,361 mainland Chinese college students. Confirmatory factor analysis (CFA) was used to examine the dimensional structure of the IPS, and multigroup CFA (MG CFA) was carried out to evaluate the measurement invariance across gender. Results revealed that the Chinese IPS had adequate internal consistency reliability, adhered to the one-factor structure, and exhibited strong or scalar invariance across the two gender subgroups, thereby providing support for the internal construct validity of the scale. Additionally, the IPS scores were found to be strongly and negatively related to the Conscientiousness personality trait while showing weak correlations with the other traits, which provided some support for the convergent and divergent validity of the Chinese IPS. Study limitations and future research directions (e.g., expanding the empirical evidence for the scale’s criterion-related validity) are discussed.
Sensor-Based Categorization of Upper Limb Performance in Daily Life of Persons With and Without Neurological Upper Limb Deficits
Authors: Barth Jessica , Lohse Keith R. , Konrad Jeffrey D. , Bland Marghuertta D. , Lang Catherine E.
Published: October 2021

Background: The use of wearable sensor technology (e. g., accelerometers) for tracking human physical activity have allowed for measurement of actual activity performance of the upper limb (UL) in daily life. Data extracted from accelerometers can be used to quantify multiple variables measuring different aspects of UL performance in one or both limbs. A limitation is that several variables are needed to understand the complexity of UL performance in daily life.

Purpose: To identify categories of UL performance in daily life in adults with and without neurological UL deficits.

Methods: This study analyzed data extracted from bimanual, wrist-worn triaxial accelerometers from adults from three previous cohorts (N = 211), two samples of persons with stroke and one sample from neurologically intact adult controls. Data used in these analyses were UL performance variables calculated from accelerometer data, associated clinical measures, and participant characteristics. A total of twelve cluster solutions (3-, 4-, or 5-clusters based with 12, 9, 7, or 5 input variables) were calculated to systematically evaluate the most parsimonious solution. Quality metrics and principal component analysis of each solution were calculated to arrive at a locally-optimal solution with respect to number of input variables and number of clusters.

Results: Across different numbers of input variables, two principal components consistently explained the most variance. Across the models with differing numbers of UL input performance variables, a 5-cluster solution explained the most overall total variance (79%) and had the best model-fit.

Conclusion: The present study identified 5 categories of UL performance formed from 5 UL performance variables in cohorts with and without neurological UL deficits. Further validation of both the number of UL performance variables and categories will be required on a larger, more heterogeneous sample. Following validation, these categories may be used as outcomes in UL stroke research and implemented into rehabilitation clinical practice.
Fermentation: Humanity’s Oldest Biotechnological Tool
Authors: Taveira Iasmin Cartaxo , Nogueira Karoline Maria Vieira , Oliveira Débora Lemos Gadelha de , Silva Roberto do Nascimento
Published: October 2021

Fermentation is a process in which sugars are transformed into a new product through chemical reactions carried out by microorganisms. Since ancient times, humans have taken advantage of the natural fermentation process to develop many products, including foods, medicines, and fuels. In this article, we provide a close look at the history of fermentation, demonstrating why this natural process is humans’ most ancient biotechnological tool. This article will help you to understand the different types of fermentation and the current uses of the fermentation process.
Assessing the Potential for Sustainable Aquaculture Development in Cambodia
Authors: Joffre Olivier M. , Freed Sarah , Bernhardt James , Teoh Shwu Jiau , Sambath Sak , Belton Ben
Published: October 2021

Inland capture fisheries are central to livelihoods and food security in Cambodia, but are under threat from growing anthropogenic pressures. Policy discourse in Cambodia increasingly frames aquaculture as a viable alternative to capture fisheries, and seeks to promote its development. This paper presents results from the first comprehensive survey of Cambodia's aquaculture value chain. The study combines qualitative (46 Key Informant Interviews) and quantitative surveys (1,204 farmers and 191 other aquaculture value chain actors) to investigate potential for aquaculture in Cambodia to grow, support livelihoods, and contribute to food security. We found the following: (i) The fish farm sector in Cambodia is comprised mainly of small family farms raising carnivorous fish species or pangasius, using direct inputs of “trash fish” harvested from the wild; (ii) Most fish seed and pelleted feed are imported, and domestic producers of these inputs struggle to compete; (iii) Fish farmed in Cambodia is mostly sold live. Farm fish are more expensive than the main species harvested from inland capture fisheries, and struggle to compete with imported farmed fish; (iv) Capture fisheries employ many times more people than aquaculture; (v) Space for aquaculture is limited because few locations have both perennial access to water and protection from flooding. These findings raise questions about the potential of Cambodia's aquaculture sector, as currently organized, to contribute significantly to employment, food and nutrition security, and rural economic development. We propose actions to improve the sector's sustainability and contribute to desirable development outcomes.
Productivity of Newly Released Common Bean (Phaseolus vulgaris L.) Varieties Under Sole Cropping and Intercropping With Maize (Zea mays L.)
Authors: Nkhata Wilson , Shimelis Hussein , Chirwa Rowland
Published: October 2021

Intercropping maize (Zea mays L.) with common bean (Phaseolus vulgaris L.) is one of the predominant farming practices in eastern and southern Africa (ESA) for effective use of resources and continuous household food supply. The productivity of sole or intercropped crops is subject to variety, location, year, and their interaction. Therefore, the objective of this study was to determine the productivity of newly released common bean varieties NUA45 and SER83 under sole cropping and intercropping with a maize hybrid variety SC672 as a guide to large-scale production. Experiments were conducted at Chitedze Agricultural Research Station (13.85°S; 33.38°E) and Linthipe Extension Planning Area (12.06°S; 33.25°E) in 2019 and 2020 in Malawi using a factorial arrangement laid out in a randomized complete block design (RCBD) with four replications. The numbers of pods per plant (NPP) and seeds per pod (NSP), grain yield (GYD), and 100-seed weight were collected for common bean included, while GYD was recorded for maize. The main effects for genotype, location, year, and intercropping system were significant (p < 0.05) for GYD in common bean. The effects of the year and cropping system and location by intercropping system interaction were significant for maize GYD. The maize yield did not vary between sole cropped and intercropped systems. The total land equivalent ratios (LERs) for NUA45 and SER83 were 1.59 and 1.77, respectively. The LER-values showed a significant difference (p < 0.034), suggesting a considerably higher benefit of maize and common bean intercropping. Overall, intercropping maize with common bean rendered higher yields in the SER83/SC672 intercropping system than the sole crop in the study areas. Therefore, intra-row intercropping of the newly released common bean variety SER83 with a maize hybrid variety SC672 is recommended in the study area and other similar agro-ecologies for stable and sustainable production of both crops.
Emergence of a New Lineage 1C Variant of Porcine Reproductive and Respiratory Syndrome Virus 2 in the United States
Authors: Kikuti Mariana , Paploski Igor A. D. , Pamornchainavakul Nakarin , Picasso-Risso Catalina , Schwartz Mark , Yeske Paul , Leuwerke Brad , Bruner Laura , Murray Deborah , Roggow Brian D. , Thomas Pete , Feldmann Lori , Allerson Matt , Hensch Melissa , Bauman Tyler , Sexton Brent , Rovira Albert , VanderWaal Kimberly , Corzo Cesar A.
Published: October 2021

We report an ongoing regional outbreak of an emerging porcine reproductive and respiratory syndrome virus (PRRSV2) variant within Lineage 1C affecting 154 breeding and grow-finishing sites in the Midwestern U.S. Transmission seemed to have occurred in two waves, with the first peak of weekly cases occurring between October and December 2020 and the second starting in April 2021. Most of cases occurred within a 120 km radius. Both orf5 and whole genome sequencing results suggest that this represents the emergence of a new variant within Lineage 1C distinct from what has been previously circulating. A case-control study was conducted with 50 cases (sites affected with the newly emerged variant) and 58 controls (sites affected with other PRRSV variants) between October and December 2020. Sites that had a market vehicle that was not exclusive to the production system had 0.04 times the odds of being a case than a control. A spatial cluster (81.42 km radius) with 1.68 times higher the number of cases than controls was found. The average finishing mortality within the first 4 weeks after detection was higher amongst cases (4.50%) than controls (0.01%). The transmission of a highly similar virus between different farms carrying on trough spring rises concerns for the next high transmission season of PRRS.
Innovative Polycomposite Fertilizer Obtained by Recycling and Processing Three Organic Wastes
Authors: Lacatusu Anca Rovena , Meghea Aurelia , Rogozea Adina Elena , Constantin Carolina
Published: October 2021

The paper aims at testing an innovative organic fertilizer obtained from waste by processing a mixture of marine algae biomass, sewage municipal sludge and farmyard manure. Design of this polycomposite fertilizer is based on adequate conceptual and experimental models by taking into account the complex interactions among these three biomasses. In the first step a detail physico-chemical analysis has been performed on the composition of the three raw materials and also on the soil. In the second phase similar analyses have been carried out on representative samples of soil treated with the compost as compared with untreated soil samples. Analytical methods applied were FT-IR spectroscopy in correlation with organic/inorganic and total carbon (TOC/TIC/TC) analysis. The efficiency of applying this compost on the field at large scale has been assessed by means of fatty acid content of the oleaginous plants cultivated. Based on correlation between production quality and chemical composition of the composted soil, the optimal proportions of the mixture of the three organic wastes will be selected for designing an eco-friendly fertilizer able to improve agrochemical properties of the soil.
Building an Agroecological Process towards Agricultural Sustainability: A Case Study from Southern Spain
Authors: González-Rosado Manuel , Parras-Alcántara Luis , Aguilera-Huertas Jesús , Lozano-García Beatriz
Published: October 2021

The urgent need to implement agricultural systems that provide greater sustainability and resilience to the challenges of the climate change process has meant that alternative paradigms for agri-food systems and agriculture have become more relevant in recent times. In this study, we present the building process and consolidation of an agro-ecological project (Extiercol) in a rural area of southern Spain, with a prolonged depopulation process and close connections to nearby urban areas. Through participatory action research, the specific objectives of this study are (1) to describe the agroecological collective process from its creation by a youth association to its establishment as a viable agricultural project; (2) to identify the drivers for the development of this type of transition process towards agricultural sustainability and (3) to analyse urban-rural alliances in the establishment of agroecological projects. Finally, the replicability of this project was assessed, with a special focus on the main barriers to be addressed in order to implement this agricultural system such as difficult to land access or a negative perception of sustainable management by farmers. Through this study we have shown how the connection between the food production area and nearby urban areas can be achieved through an agroecological project.
Influence of Different Spent Mushroom Substrates on Yield, Morphological and Photosynthetic Parameters of Strawberry (Fragaria × ananassa Duch.)
Authors: Prasad Raghavendra , Lisiecka Jolanta , Antala Michal , Rastogi Anshu
Published: October 2021

The present study aimed to evaluate fresh spent mushroom substrate (SMS) as a growing medium in soilless strawberry cv. ‘Honeoye’ production. Fresh SMS after commercial production of Agaricus bisporus, Lentinus edodes, and Pleurotus ostreatus was used as a peat substitute in 15 and 25% (v/v), for strawberry cultivation in an unheated plastic tunnel. In the experiment, seven different substrates were studied, including peat (100%) as control and six substrate combinations (prepared by mixing SMSs with peat). The study was carried out in a randomized complete block design in five replicates. The results indicated that the electrical conductivity (EC), pH, and nutrient content varied among the studied substrates. The experiment also demonstrated that the substrates significantly influenced strawberry yield, leaf area, and fresh and dry plant weights. However, no significant differences were observed for selected photosynthetic parameters (Fv/Fm, Fv/F0, and PIabs) and Normalized Difference Vegetation Index (NDVI) values among the evaluated substrates. Differences were recorded for the Photochemical Reflectance Index (PRI) and Modified Chlorophyll Absorption in Reflectance Index (MCARI) values. The present investigation revealed that fresh SMSs can be an effective and inexpensive peat substitute in 15 and 25% (v/v). Therefore, such easy and immediate utilisation of SMSs could overcome associated disposal problems.
Synthesis and Characterization of Camphorimine Au(I) Complexes with a Remarkably High Antibacterial Activity towards B. contaminans and P. aeruginosa
Authors: Costa Joana P. , Sousa Sílvia A. , Soeiro Catarina , Leitão Jorge H. , Galvão Adelino M. , Marques Fernanda , Carvalho M. Fernanda N. N.
Published: October 2021

Fourteen new camphorimine Au(I) complexes were synthesized and characterized by spectroscopic (NMR, FTIR) and elemental analysis. The structural arrangement of three selected examples were computed by Density Functional Theory (DFT) showing that the complexes essentially keep the {AuI-CN} unit. The Minimum Inhibition Concentrations (MIC) were assessed for all complexes showing that they are active towards the Gram-negative strains E. coli ATCC25922, P. aeruginosa 477, and B. contaminans IST408 and the Gram-positive strain S. aureus Newman. The complexes display very high activity towards P. aeruginosa 477 and B. contaminans IST408 with selectivity towards B. contaminans. An inverse correlation between the MIC values and the gold content was found for B. contaminans and P. aeruginosa. However, plots of MIC values and Au content for P. aeruginosa 477 and B. contaminans IST408 follow distinct trends. No clear relationship could be established between the MIC values and the redox potentials of the complexes measured by cyclic voltammetry. The MIC values are essentially independent of the redox potentials either cathodic or anodic. The complexes K3[{Au(CN)2}3(A4L)] (8, Y = m-OHC6H4) and K3[{Au(CN)2}3(B2L)]·3H2O (14, Z = p-C6H4) display the lower MIC values for the two strains. In normal fibroblast cells, the IC50 values for the complexes are ca. one order of magnitude lower than their MIC values, although higher than that of the precursor KAu(CN)2.
Current Status and Future Perspectives on Therapeutic Potential of Apigenin: Focus on Metabolic-Syndrome-Dependent Organ Dysfunction
Authors: Alam Waqas , Rocca Carmine , Khan Haroon , Hussain Yaseen , Aschner Michael , De Bartolo Anna , Amodio Nicola , Angelone Tommaso , Cheang Wai San
Published: October 2021

Metabolic syndrome and its associated disorders such as obesity, insulin resistance, atherosclerosis and type 2 diabetes mellitus are globally prevalent. Different molecules showing therapeutic potential are currently available for the management of metabolic syndrome, although their efficacy has often been compromised by their poor bioavailability and side effects. Studies have been carried out on medicinal plant extracts for the treatment and prevention of metabolic syndrome. In this regard, isolated pure compounds have shown promising efficacy for the management of metabolic syndrome, both in preclinical and clinical settings. Apigenin, a natural bioactive flavonoid widely present in medicinal plants, functional foods, vegetables and fruits, exerts protective effects in models of neurological disorders and cardiovascular diseases and most of these effects are attributed to its antioxidant action. Various preclinical and clinical studies carried out so far show a protective effect of apigenin against metabolic syndrome. Herein, we provide a comprehensive review on both in vitro and in vivo evidence related to the promising antioxidant role of apigenin in cardioprotection, neuroprotection and renoprotection, and to its beneficial action in metabolic-syndrome-dependent organ dysfunction. We also provide evidence on the potential of apigenin in the prevention and/or treatment of metabolic syndrome, analysing the potential and limitation of its therapeutic use.
A Computational Study on the Aeroacoustics of a Multi-Rotor Unmanned Aerial System
Authors: Heydari Morteza , Sadat Hamid , Singh Rajneesh
Published: October 2021

The noise generated by a quadrotor biplane unmanned aerial system (UAS) is studied computationally for various conditions in terms of the UAS pitch angle, propellers rotating velocity (RPM), and the UAS speed to understand the physics involved in its aeroacoustics and structure-borne noise. The k-ω SST turbulence model and Ffowcs Williams-Hawkings equations are used to solve the flow and acoustics fields, respectively. The sound pressure level is measured using a circular array of microphones positioned around the UAS, as well as at specific locations on its structure. The local flow is studied to detect the noise sources and evaluate the pressure fluctuation on the UAS surface. This study found that the UAS noise increases with pitch angle and the propellers’ rotating velocity, but it shows an irregular trend with the vehicle speed. The major source of the UAS noise is from its propellers and their interactions with each other at small pitch angle. The propeller and CRC-3 structure interaction contributes to the noise at large pitch angle. The results also showed that the propellers and structure of the UAS impose unsteadiness on each other through a two-way mechanism, resulting in structure-born noises which depend on the propeller RPM, velocity and pitch angle.
Developing the Smart Sorting Screw System Based on Deep Learning Approaches
Authors: Lin Wan-Ju , Chen Jian-Wen , Young Hong-Tsu , Hung Che-Lun , Li Kuan-Ming
Published: October 2021

The deep learning technique has turned into a mature technique. In addition, many researchers have applied deep learning methods to classify products into defective categories. However, due to the limitations of the devices, the images from factories cannot be trained and inferenced in real-time. As a result, the AI technology could not be widely implemented in actual factory inspections. In this study, the proposed smart sorting screw system combines the internet of things technique and an anomaly network for detecting the defective region of the screw product. The proposed system has three prominent characteristics. First, the spiral screw images are stitched into a panoramic image to comprehensively detect the defective region that appears on the screw surface. Second, the anomaly network comprising of convolutional autoencoder (CAE) and adversarial autoencoder (AAE) networks is utilized to automatically recognize the defective areas in the absence of a defective-free image for model training. Third, the IoT technique is employed to upload the screw image to the cloud platform for model training and inference, in order to determine if the defective screw product is a pass or fail on the production line. The experimental results show that the image stitching method can precisely merge the spiral screw image to the panoramic image. Among these two anomaly models, the AAE network obtained the best maximum IOU of 0.41 and a maximum dice coefficient score of 0.59. The proposed system has the ability to automatically detect a defective screw image, which is helpful in reducing the flow of the defective products in order to enhance product quality.
Biosignal-Based Driving Skill Classification Using Machine Learning: A Case Study of Maritime Navigation
Authors: Xue Hui , Batalden Bjørn-Morten , Sharma Puneet , Johansen Jarle André , Prasad Dilip K.
Published: October 2021

This work presents a novel approach to detecting stress differences between experts and novices in Situation Awareness (SA) tasks during maritime navigation using one type of wearable sensor, Empatica E4 Wristband. We propose that for a given workload state, the values of biosignal data collected from wearable sensor vary in experts and novices. We describe methods to conduct a designed SA task experiment, and collected the biosignal data on subjects sailing on a 240° view simulator. The biosignal data were analysed by using a machine learning algorithm, a Convolutional Neural Network. The proposed algorithm showed that the biosingal data associated with the experts can be categorized as different from that of the novices, which is in line with the results of NASA Task Load Index (NASA-TLX) rating scores. This study can contribute to the development of a self-training system in maritime navigation in further studies.
Numerical Study of the Transmission of Exhaled Droplets between the Instructor and Students in a Typical Classroom
Authors: Farouk Mohamed Ismail , Nassar Ahmed Fayez , Elgamal Mohamed Hassan
Published: October 2021

Conducting physical attendance exams during pandemics is a challenge facing many educational institutes and universities. Our study’s main objective is to numerically simulate the expected transmission of the harmful exhaled droplets of aerosols from an infected instructor to students in an exam room ventilated by a number of spiral diffusers. Several critical parameters, including the droplet size, the ventilation rate, and status of the entrance door were considered in the analysis. Two dimensionless indices, i.e., the specific normalized average concentration (SNAC) and the exceedance in exposure ratio (EER), were introduced to examine the effect of the said parameters on student exposure to the harmful droplets. The study revealed that the 5 μm droplets were less hazardous as they resulted in an 87% reduction in exposure when compared with the small 1 μm size droplets. We also found that when the ventilation rate ratio (VRR) increased above unity, an upward entrainment process, due to the swirl diffuser, of the aerosol droplets took place, and consequently the risk of student exposure was reduced. The results also demonstrated that increasing VRR from zero to 1 and then to 2 decreased the exceedance in the student exposure from 3.5 to 2.15 and then to less than zero, respectively. The study also showed that keeping the lecture room’s main door open is recommended as this reduced the risk of exposure by 26% in the case of a VRR equal to 2.
Reduced Reference Quality Assessment for Image Retargeting by Earth Mover’s Distance
Authors: Wei Longsheng , Zhao Lei , Peng Jian
Published: October 2021

A reduced reference quality assessment algorithm for image retargeting by earth mover’s distance is proposed in this paper. In the reference image, all the feature points are extracted using scale invariant feature transform. Let the histograms of image patch around each feature point be local information, and the histograms of saliency feature as global information. Those feature information is extracted at the sender side and transmitted to the receiver side. After that, the same feature information extraction process is performed for the retargeted image at the receiver side. Finally, all feature information of the reference and retargeted images is used collectively to compute the quality of the retargeted image. An overall quality score is calculated from the local and global similarity measure using earth mover’s distance between reference and retargeted images. The key step in our algorithm is to provide an earth mover’s distance metric in a manner that indicates how the local and global information in the reference image is preserved in corresponding retargeted image. Experimental results show that the proposed algorithm can improve the image quality scores on four common criteria in the retargeted image quality assessment community.
Frequency Converter as a Node for Edge Computing of Big Data, Related to Drive Efficiency, in Industrial Internet of Things
Authors: Hetmańczyk Mariusz Piotr , Malaka Julian
Published: October 2021

The article presents a method of generating key performance indicators related to electric motor energy efficiency on the basis of Big Data gathered and processed in a frequency converter. The authors proved that using the proposed solution, it is possible to specify the relation between the control mode of an electric drive and the control quality-energy consumption ratio in the start-up phase as well as in the steady operation with various mechanical loads. The tests were carried out on a stand equipped with two electric motors (one driving, the other used to apply the load by adjusting the parameters of the built-in brake). The measurements were made in two load cases, for motor control modes available in industrially applied frequency converters (scalar V/f, vector Voltage flux control without encoder, vector voltage flux control with encoder, vector current flux control, and vector current flux control with torque control). During the experiments, values of the current intensities (active and output), the actual frequency value, IxT utilization factor, relative torque, and the current rotational speed were measured and processed. Based on the data, the level of energy efficiency was determined for various control modes.