bluuebunny/crossref_metadata_2025 huggingface dataset:
Pseudoallergen-free diet in the treatment of chronic urticaria. A prospective study.
Authors: Zuberbier T , Chantraine-Hess S , Hartmann K , Czarnetzki B M
Published: June 2023

In chronic urticaria, the possible pathogenetic role of pseudoallergic reactions to food has been repeatedly discussed, but stringent prospective studies regarding their clinical significance are not available. All patients with chronic urticaria and/or angioedema hospitalized at the department of dermatology during a period of 2 years were therefore included in a prospective study. Patients (n = 64) were screened for common causes of urticaria and then evaluated for possible benefits of a stringently controlled pseudoallergen-free diet. Double-blind, placebo-controlled oral provocation tests with food additives were performed on those patients benefitting from diet. In 73% of patients, symptoms ceased or were greatly reduced within 2 weeks on diet, although only 19% of them responded to individual pseudoallergens on provocation tests. Of the remaining patients, 11% responded to treatment of an associated inflammatory disease, and in 16%, no cause of the urticaria was ascertained. Follow-up at 6 months after hospitalization showed complete remission on diet in 46% and lasting improvement in all but one of the remaining patients on diet. An additive-free, stringently controlled diet thus provides a simple means of diagnosing and treating the majority of patients with chronic urticaria.
Occurrence and distribution of peptidergic nerve fibers in skin biopsies from patients with systemic sclerosis.
Authors: Wallengren J , Akesson A , Scheja A , Sundler F.
Published: June 2023

Systemic sclerosis is characterized by vascular dysfunction. Itch is sometimes present in early stages of the disease. This prompted us to study the innervation of the skin by immunocytochemistry. Antibodies to neuropeptide Y and vasoactive intestinal peptide were used for autonomic nerves. Sensory innervation was studied using antibodies to substance P and calcitonin gene-related peptide. Protein gene product 9.5 was used as a general neuronal marker. Skin biopsies from affected (lower arm) and non-affected (upper back) sites on 10 patients with systemic sclerosis and from corresponding sites on 10 sex- and age-matched healthy controls were studied. Regional variations were found in the occurrence of peptidergic nerve fibers. In the patients the density of nerve fibers (measured semiquantitatively) stained by the panneuronal marker was lower in affected than in unaffected skin (p < 0.05). There were no significant differences in peptidergic innervation between patients and controls. However, there was a tendency to higher density of neuropeptide Y-positive nerve fibers in the forearm skin in 6 to 10 patients, as compared to only 1 of 10 healthy controls.
Effects of topical application of capsaicin to human skin: a comparison of effects evaluated by visual assessment, sensation registration, skin blood flow and cutaneous impedance measurements.
Authors: Magnusson BM , Koskinen LO.
Published: June 2023

A new non-invasive device, which enables local measurements of electrical impedance, has been used to evaluate the degree of irritation in human skin. The results have been compared with visual scoring, sensations and laser Doppler flowmetry. Capsaicin (50 microliters 1% solution) and control solutions (50 microliters 50% ethanol) were applied in a chamber for 30 min on the volar forearm of 7 volunteers. Values were recorded before application and during the total test period of 4.5 h. Sensations like sting/prick, burn and pain were produced by this treatment, and the flare response was observed. Using the non-invasive laser Doppler flow technique to measure blood flow in human skin, we have shown that topical application of capsaicin abolishes the vasodilator response to local heat provocation (40 degrees C). There was close agreement among values obtained using visual assessments, sensations and laser Doppler flowmetry. Results obtained using electrical impedance measurements were not consistent with the other three methods.
Generalized morphea with vascular involvement. A case report and disaccharide analysis of the skin glycosaminoglycans.
Authors: Akimoto S , Ishikawa O , Yokoyama Y , Amano H , Miyachi Y.
Published: June 2023

We report a 69-year-old man with severe generalized morphea, who showed over 80% of skin involvement, while the internal organs were not affected. We performed histological examinations and analysis of skin disaccharides constituting chondroitinase-digestible glycosaminoglycans in the center and periphery of the sclerotic lesions and the clinically uninvolved skin. In both the central and peripheral parts of the sclerotic lesions, sclerotic fibrosis and a dense perivascular cell infiltration, consistent with morphea, were seen in the entire dermis and subcutis. Furthermore, various vascular changes were observed, such as endothelial cell swell, thickened basement membrane and obstruction of vascular lumen in the fat lobules. In the clinically uninvolved skin, interstitial edema was prominent along with a slight perivascular cell infiltration. On disaccharide analysis, the increase in the amount of delta Di-4S(DS), the main disaccharide unit of dermatan sulphate, delta Di-6S and delta Di-6S, the main disaccharide units of chondroitin sulphate, and the decrease in delta Di-HA, which is derived from hyaluronate, were found not only in the sclerotic lesions but also in the clinically uninvolved skin, though less prominent. These alterations were consistent with systemic sclerosis, suggesting a close relationship between severe forms of generalized morphea and systemic sclerosis.
Casual sex, extramarital sex, condom use and alcohol intake among heterosexual patients attending an STD clinic in Norway.
Authors: Tveit KS , Nyfors A , Nilsen A.
Published: June 2023

A study excluding homosexuals was performed to study casual sex, extramarital sex, the use of a condom with a casual sexual partner and the combination of alcohol intake and casual sex among patients attending a clinic for sexually transmitted diseases (STDs). Heterosexual patients (467) received a questionnaire, and 458 were included. Men reported more (94%) casual sexual partners than did women (76%). According to a multiple logistic regression analysis a condom was used significantly less frequently in "old" respondents, those having a permanent sexual partner, those having low education, those infected with STDs (earlier STDs), those who had had more than 4 sexual partners over the last year, and those combining alcohol intake and casual sex. Intravenous drug users/prostitutes used a condom more often than did men with paid sex and "other heterosexuals". To have an effect on STD patients, innovative forms of health education may be necessary, and greater emphasis should be placed on more informal means of information, including interactive health education and communication strategies to promote positive attitudes regarding condom use.
Association between expression of stratum corneum chymotryptic enzyme and pathological keratinization in human oral mucosa.
Authors: Sondell B , Dyberg P , Anneroth GK , Ostman PO , Egelrud T.
Published: June 2023

Stratum corneum chymotryptic enzyme (SCCE) may function in the degradation of intercellular cohesive structures in the stratum corneum preceding desquamation. Previous results have suggested that SCCE may be specifically expressed in squamous epithelia undergoing terminal differentiation and keratinization. The aim of the present work was to further elucidate the association between SCCE expression and terminal differentiation in squamous epithelia. Using immunohistochemical methods, we have examined the expression of SCCE in two diseases of human oral mucosa, which produce a pathological keratinization of the epithelium at sites which are normally non-keratinized. Affinity-purified polyclonal rabbit antibodies raised against recombinant SCCE and monoclonal antibodies against the differentiation-specific keratins nos. 10 and 13 were used on formaldehyde-fixed and paraffin-embedded biopsies. Whereas there was essentially no expression of SCCE in normal, non-keratinized buccal mucosa, there was a strong expression in suprabasal cells in orthokeratotic and parakeratotic areas of the lesions of oral lichen planus (an inflammatory disease) and benign oral keratosis (a non-inflammatory disease). There was a close association between the expression of SCCE and keratin no. 10, i.e. a keratin which is specifically expressed in cornifying squamous epithelia. The results suggest that SCCE expression may be a true marker of terminal differentiation in squamous epithelia and give further evidence for a role of SCCE in the formation and/or turnover of the stratum corneum.
Expression of the p53 protein in sun-damaged skin.
Authors: Barnadas MA , Colomo L , Curell R , De Moragas JM.
Published: June 2023

The expression of the p53 protein in photodamaged skin from the face, forearm and neck of 18 subjects was compared to non-exposed skin taken at autopsy from the abdomens of 9 subjects of the same age. Paraffin sections and the polyclonal antibody CM1 were used with the ABC technique. The p53 protein was expressed in the nuclei of keratinocytes in 7 of the 18 samples obtained from sun-exposed skin and in 1 of 9 samples from non-exposed skin. The expression in sun-exposed skin can be due either to its overexpression due to DNA damage or to the appearance of mutant forms.
Diagnosis of Chlamydia trachomatis infection in high-risk females with PCR on first void urine.
Authors: Olafsson JH , Davídsson S , Karlsson SM , Pálsdóttir R , Steingrímsson O.
Published: June 2023

Recently the polymerase chain reaction (PCR) has been shown to be more sensitive than older methods in detecting Chlamydia trachomatis, when performed on endocervical swabs. A total of 203 high-risk females were enrolled in a comparative study of 3 methods for diagnosing C. trachomatis infections: McCoy cell culture and Amplicor PCR on endocervical swabs, and urine. Thirty-four had positive cultures, 38 positive PCR from cervix and 37 had positive PCR on urine specimens. When discrepancy occurred, the leftover Amplicor specimen was retested by Roche with Amplicor and a primer for the major outer membrane protein (MOMP) gene. In all three tests, 32 were positive. The sensitivity of culture was 87%, 92% in cervical PCR and 95% in urinary PCR. The specificity was 100% in both culture and urinary PCR but 98% in cervical PCR. Amplicor PCR performed on female urine is at least as sensitive and specific as cell culture.
Infantile acrodermatitis of Gianotti-Crosti and Lyme borreliosis.
Authors: Baldari U , Cattonar P , Nobile C , Celli B , Righini MG , Trevisan G.
Published: June 2023

No abstract available
A giant solitary molluscum contagiosum, resembling nodular basal cell carcinoma, in a renal transplant recipient.
Authors: Taşkapan O , Yenicesu M , Aksu A.
Published: June 2023

No abstract available
Scrotal angiokeratoma in a young man.
Authors: Hisa T , Taniguchi S , Goto Y , Teramae H , Osato K , Kakudo K , Takigawa M.
Published: June 2023

No abstract available
The sarcoidosis-lymphoma syndrome: acceleration of the cutaneous sarcoidosis during chemotherapy of the lymphoma.
Authors: Keohane SG , Savin JA , Tidman MJ , Anderson JA , Carey FA.
Published: June 2023

No abstract available
Paraneoplastic pemphigus: oral involvement as the sole manifestation.
Authors: Bialy-Golan A , Brenner S , Anhalt GJ.
Published: June 2023

No abstract available
Congenital ectopic nails of the fingers is associated with bone deformities.
Authors: Kuniyuki S.
Published: June 2023

No Abstract avaliable
A quantitative description of echographic images of sclerotic skin in patients with systemic sclerosis, as assessed by computerized image analysis on 20 MHz B-scan recordings.
Authors: Seidenari S , Belletti B , Conti A.
Published: June 2023

The aim of our study was to find image descriptors enabling the characterization of sclerotic skin and its differentiation from normal skin, in order to find an objective method for the assessment of skin involvement in systemic sclerosis (SSc). Echographic evaluations were carried out using a 20 MHz B-scanner, on 18 female patients with SSc and on 20 healthy women serving as controls, at 3 different skin sites (forehead, cheek and back of the hand). Images were processed by a program, based on segmentation procedures and object description, employing 5 different amplitude bands and the following parameters: 1) the extension of image areas marked by amplitude bands of interest, 2) the percentage of the image surface reflecting within a homogeneous amplitude band, 3) the number of objects composing the image, 4) the average object size, and 5) the "density" of the objects. At all 3 skin sites, marked differences in the echostructure of the tissue between patients with SSc and the controls were observable. In SSc patients forehead skin appeared thinner and more echogenic, with smaller hypo-reflecting objects and greater hyper-reflecting areas
Comparison of cyclosporine and topical betamethasone-17,21-dipropionate in the treatment of severe chronic hand eczema.
Authors: Granlund H , Erkko P , Eriksson E , Reitamo S.
Published: June 2023

Topical corticosteroids are the standard treatment for hand eczema. However, in chronic forms of the disease they are often ineffective or lose their efficacy due to tachyphylaxis. In a previous open study cyclosporine showed efficacy in chronic hand eczema. The aim of this study was to compare oral cyclosporine at 3 mg/kg/day with topical 0.05% beta-methasone-17,21-dipropionate (BDP) cream in the treatment of chronic hand eczema. In a randomized, double-blind study 41 patients with chronic hand eczema resistant to conventional treatment were assigned to either cyclosporine or BDP for 6 weeks. Both cyclosporine and BDP improved the eczema. The total disease activity score decreased to 57% of baseline in the cyclosporine group (mean change -6, SD 4.3
Generalised acanthosis nigricans with vitiligo.
Authors: Blume-Peytavi U , Spieker T , Reupke H , Orfanos CE.
Published: June 2023

We report on a 19-year-old woman with generalised acanthosis nigricans of the inherited type and concomitant vitiligo. Cutaneous velvety thickening of the skin with intensification of skin markings and progressive development of hyperpigmented papillomatous, verrucoid lesions in the body folds started to develop in early childhood. These hyperpigmentations were continuously replaced by a progressive vitiligo, finally leaving most of the acanthosis nigricans lesions completely depigmented. Generalised, pachyderma-like acanthosis nigricans with concomitant vitiligo is an association which to the best of our knowledge has not yet been described.
Drug photosensitivity in Norway.
Authors: Selvaag E , Thune P.
Published: June 2023

No abstract available.
Bronchial asthma and allergic rhinitis in patients with hereditary palmoplantar keratoderma.
Authors: Gamborg Nielsen P.
Published: June 2023

No abstract available.
Pruritus ani caused by beta-haemolytic streptococci.
Authors: Weismann K , Sand Petersen C , Røder B.
Published: June 2023

No abstract available.
Irritancy testing in occupational dermatology: comparison between two quick tests and the acute irritation induced by sodium lauryl sulphate.
Authors: Bangha E , Hinnen U , Elsner P.
Published: June 2023

To reduce the incidence of irritant contact dermatitis, the development of screening methods to identify subjects with increased susceptibility to irritants is essential. In a pilot study on the comparison between two quick, non-invasive irritancy tests (dimethyl sulfoxide (DMSO) and sodium hydroxide (NaOH) with the time-consuming patch testing with sodium lauryl sulphate (SLS), no correlation between the "quick tests" and SLS patch testing was observed. In the present paper the results of irritancy testing in 181 metal worker trainees are presented. Experimental irritant contact dermatitis reactions were induced on the medial third of the volar forearm using SLS 0.5%, applied for 23 h and as "quick tests" DMSO 90% and 95% and a solution of 0.2% mol/l NaOH applied for 5 min. Assessment of skin irritability was made by visual scoring and measurement of transepidermal water loss. Except for a statistically significant relationship between the irritations by DMSO 90% and 95%, correlations between the different techniques were weak or non-existent. This is most probably due to different pathophysiological pathways for the irritant reactions. We therefore propose to use a spectrum of different tests in occupational dermatology for predicting the individual's risk of irritant contact dermatitis.
Atopic dermatitis may be linked to whether a child is first- or second-born and/or the age of the mother.
Authors: Olesen AB , Ellingsen AR , Larsen FS , Larsen PO , Veien NK , Thestrup-Pedersen K.
Published: June 2023

Five hundred and thirty families with at least 1 child who had been referred to a dermatologist with atopic dermatitis were interviewed in an effort to determine whether factors such as the age of the mother when a child is born and/or birth rank can contribute to the development of atopic dermatitis. The families interviewed had a total of 1,084 children, or an average of 2 children per family. Sixty per cent of the children with atopic dermatitis were under 5 years of age. Ninety-one per cent of them had developed the disease before the age of 3
PUVA in early mycosis fungoides may give long-term remission and delay extracutaneous spread.
Authors: Roupe G , Sandström MH , Kjellström C.
Published: June 2023

We report a follow-up for 3-18 years of 24 patients with the non-infiltrated patch and infiltrated plaque stage of mycosis fungoides, treated with psoralen photochemotherapy (PUVA) and on resistant infiltration or development of tumours also with fractionated radiation therapy. All patients with patch and limited plaques showed complete remission after initial PUVA therapy. Half of the patients with patch stage mycosis fungoides and also half of the patients with plaque stage mycosis fungoides were in complete remission when the study ended. Most of them had remission periods for years after early PUVA treatment. Patients with more advanced mycosis fungoides needed repeated periods of PUVA therapy. Two patients with extensive infiltrated plaques did not reach complete remission at all during the study but progressed and finally died of their T-cell lymphoma. Another 4 patients with extensive plaque stage mycosis fungoides died after initial complete remission for a maximum of 3 years. In this investigation the clinical evaluation was made by one dermatologist and the histopathological evaluation by one pathologist. This is of importance since in the early stages of mycosis fungoides the diagnosis is challenging and may require a combination of clinical, histopathological and molecular evaluations. The identification of early disease is crucial for the rapid implementation of adequate treatment. The study shows that early PUVA therapy may delay extracutaneous spread and possibly also in some cases be curative.
PUVASOL therapy in palmoplantar psoriasis.
Authors: Kaur I , Kumar R , Kumar B.
Published: June 2023

No abstract available
Increased urinary excretion of N-acetyl-beta-D-glucosaminidase in patients affected with psoriasis.
Authors: Cecchi R , Giomi A , Ciuti M , Seghieri G.
Published: June 2023

No abstract available
Langerhans' cells in cervical condyloma and intraepithelial neoplasia in smoking and non-smoking adolescents.
Authors: Derchain SF , Vassallo J , Pinto GA , Irazusta SP , Andrade LA.
Published: June 2023

No abstract available
Serum levels of soluble CD14 in scleroderma.
Authors: Bruns M , Hofmann C , Herrmann K , Haustein UF.
Published: June 2023

No abstract available
Tungiasis presenting with sterile pustular lesions on the hand.
Authors: Veraldi S , Camozzi S , Scarabelli G.
Published: June 2023

No abstract available
Effectiveness of 4% disodium cromoglycate in the treatment of disseminated pyoderma gangrenosum.
Authors: Langenbach N , Goetz A , Hohenleutner U , Landthaler M.
Published: June 2023

No abstract available
Generalized pustular psoriasis in Japan: two distinct groups formed by differences in symptoms and genetic background.
Authors: Ohkawara A , Yasuda H , Kobayashi H , Inaba Y , Ogawa H , Hashimoto I , Imamura S.
Published: June 2023

A multi-center study for investigating generalized pustular psoriasis was carried out in Japan in order to clarify the prevalence, the etiology, and the standard therapy. Through questionnaires, 541 cases of patients with generalized pustular psoriasis and related disorders were collected, and the history, the precipitating factors, the symptoms and the laboratory findings were analyzed from medical records. The statistic analysis revealed that 902 (+/- 102.2) patients with generalized pustular psoriasis were expected at the time, and that the prevalence of generalized pustular psoriasis in Japan was 7.46/million. Of 541 patients with generalized pustular psoriasis, 208 cases had the recurrent episodes of symptoms with generalized pustules which had been referred to von Zumbusch type pustular psoriasis or to the acute form of generalized pustular psoriasis. Two hundred and eight patients were further subdivided into two groups: one with a preceding history of ordinary psoriasis (pso+ generalized pustular psoriasis
Cutaneous Horn in a lesion of prurigo nodularis.
Authors: Khaitan BK , Bajaj N , Verma KK.
Published: June 2023

No abstract available.
Skin-derived antileukoproteinase (SKALP) and epidermal fatty acid-binding protein (E-FABP): two novel markers of the psoriatic phenotype that respond differentially to topical steroid.
Authors: Kuijpers AL , Bergers M , Siegenthaler G , Zeeuwen PL , Van de Kerkhof PC , Schalkwijk J.
Published: June 2023

Recently we have described two novel markers for disturbed epidermal differentiation, which are strongly upregulated in psoriatic epidermis: skin-derived antileukoproteinase (SKALP) and epidermal fatty acid-binding protein (E-FABP). No data are available on the kinetics of SKALP and E-FABP expression in vivo and the relation with epidermal growth and differentiation. We used treatment of lesional psoriatic skin with topical steroid as a model to correlate the expression pattern of SKALP and E-FABP with known cell biological events during regression of the psoriatic lesion. Expression of these markers was studied using immunohistochemistry and Northern blot analysis. After 4 weeks of treatment a substantial clinical improvement was induced by the topical steroid, whereas no significant improvement had occurred at the placebo-treated sides. The expression of SKALP following treatment with steroid was nearly undetectable both at the protein and mRNA level. Mitotic activity, as measured by Ki-67 staining, and cytokeratin 16 expression were downregulated to normal levels in the steroid-treated epidermis. In contrast, although there was a marked decrease of E-FABP mRNA, the staining pattern for E-FABP at the protein level was not affected. After 4 weeks of treatment with steroid the complete suprabasal compartment remained positive, even after considerable clinical improvement of the lesion. We conclude that SKALP and cytokeratin 16 are markers that are downregulated even before complete macroscopic clearance of the lesion. The kinetics of E-FABP expression is distinct from the other molecules and lags behind the clinical signs of psoriasis.
Topically applied aspirin rapidly decreases histamine-induced itch.
Authors: Yosipovitch G , Ademola J , Lui P , Amin S , Maibach HI.
Published: June 2023

The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04). Histamine injection caused elevation of warmth sensation threshold (p = 10(-8)) but did not affect cold and heat pain thresholds. Aspirin and vehicle application did not affect thermal and pain thresholds during histamine-induced itch. The current data suggest that topical application of aspirin may be beneficial for the treatment of histamine-mediated itch. Its therapeutic role in the management of clinical itch remains to be determined.
The flashlamp-pumped dye laser and dermabrasion in psoriasis--further studies on the reversed Köbner phenomenon.
Authors: Bjerring P , Zachariae H , Søgaard H.
Published: June 2023

Eleven patients with chronic plaque psoriasis were treated with the flashlamp-pumped pulsed dye laser and 6 of the same patients were at the same time treated by dermabrasion. Complete remissions were observed in 3 patients following laser-treatment and in 5 of 6 after dermabrasion. The observation periods were from 4 to 9 months. Our data suggest that the mechanism of the reversed Köbner phenomenon, which is thought to be responsible for the results of dermabrasion, is partly due to destruction of the dermal papillary vasculature. Partial responses were seen in 6 laser-treated and in one patient treated by dermabrasion. Two patients showed no response to laser treatment. These clinically unsatisfactory results can be explained by the great variety in thickness of plaques and in variability of penetration of the laser light. Measurements of absorption and scattering properties of plaques scheduled for laser treatment could probably allow improvements in the technique by optimizing laser beam diameter and pulse duration as well as wavelength and energy levels. The use of the dye laser is far less traumatic to the patient than dermabrasion.
Pigmentary demarcation lines type B in a white non-pregnant woman.
Authors: Delmonte S , Parodi A , Rebora A.
Published: June 2023

No Abstract available
Localized bullous pemphigoid after radiation therapy: two cases.
Authors: Ohata C , Shirabe H , Takagi K , Kawatsu T , Hashimoto T.
Published: June 2023

No abstract available.
Familial pityriasis rotunda.
Authors: Guberman D , Lichtenstein DA , Gilead L , Vardy DA , Klaus SN.
Published: June 2023

No abstract available.
In situ expression and serum levels of tumour necrosis factor alpha receptors in patients with lichen planus.
Authors: Simon Jr M , Gruschwitz MS.
Published: June 2023

In lichen planus (LP), an inflammatory skin disease of unknown origin, adhesion molecules and their ligands combined with the local and systemic release of various cytokines are fundamental in regulating inflammation. Therefore, we investigated the expression of tumour necrosis factor alpha receptor (TNF-R) I and II in lesional skin of 15 patients suffering from acute eruptive LP by means of immunohistochemistry. In addition, the serum levels of their soluble forms (sTNF-R) were measured by enzyme-linked immunosorbent assay (ELISA), compared with those of healthy volunteers (n = 10) and correlated with the in situ inflammatory response. In contrast to healthy controls, LP patients showed significantly increased serum levels of sTNF-RI as well as sTNF-RII (p < 0.02). These enhanced serum titres were correlated with a prominent expression of TNF-RI
Histopathological findings, viral DNA distribution and lymphocytic immunophenotypes in vesicular and papular types of herpes zoster.
Authors: Yi JY , Kim TY , Shim JH , Cho BK , Kim CW.
Published: June 2023

The characteristics rash of herpes zoster begins as erythematous macules and papules, progressing to vesicles within 12-24 h. Patients with persistent papules without vesicular change are occasionally found. Our aim was to elucidate differences in vesicular and papular types of herpes zoster. Biopsy specimens from 21 patients were examined by an in situ hybridization method to observe viral distribution, and lymphocytic immunophenotypes were evaluated immunohistochemically. There was no differences in cell-mediated immunity or immunophenotypes in lymphocytic infiltrates between vesicular and papular types of herpes zoster. DNA of varicella-zoster virus was detected in the epidermis and hair follicles in the vesicular type but was found in the pilosebaceous unit in the papular type. This indicates that the appearance of clinical types of herpes zoster depends on the infected site of varicella-zoster virus in the tissue.
Seasonal variation of skin pigmentation.
Authors: Lock-Andersen J , Wulf HC.
Published: June 2023

We measured skin pigmentation by skin reflectance monthly from May 1992 to April 1993 in 36 healthy Caucasians. Pigmentation was measured at four UV-exposed sites at the forehead, the upper chest, the inside of the upper arm, and at the upper back. The pigmentation and UV sensitivity were simultaneously measured at UV-protected buttock skin. The results showed a considerable seasonal variation for skin pigmentation at the UV-exposed sites. Buttock skin had a pigmentation and UV sensitivity that varied only marginally. We recommend that measurements of genetically controlled skin pigmentation and constitutive UV sensitivity should be performed at UV-unexposed skin on the buttocks, except in persons that expose this site to artificial or natural sunlight.
Acute generalized exanthematous pustulosis induced by lansoprazole.
Authors: Dewerdt S , Vaillant L , Machet L , De Muret , Lorette G.
Published: June 2023

No abstract available
Lymphangioma circumscriptum of the penis.
Authors: Drago F , Rampini P , Muzio G , Rebora A.
Published: June 2023

No abstract available
Substance P binding to peripheral blood mononuclear leukocytes in atopic dermatitis.
Authors: Ostlere LS , Gordon DJ , Ayliffe MJ , Rustin MH , Pereira RS , Holden CA.
Published: June 2023

Substance P has various immunomodulatory effects, including in vitro modification of lymphocyte proliferation and cytokine release. Elevated levels of substance P and increased staining of substance P-positive nerve fibres have been reported in atopic dermatitis patients. We examined fluoresceinated substance P binding to a range of lymphocyte subsets and compared the results in atopic dermatitis, non-atopic psoriasis patients and normal controls. Fluoresceinated substance P and phycoerythrin-labelled monoclonal antibodies to CD3, CD4, CD8, CD57, CD19 and CD14 were incubated in duplicate with Ficoll-Hypaque separated peripheral blood mononuclear leukocytes. With flow cytometry the fluoresceinated substance P-positive cells were identifiable as a peak of positively fluorescent cells, and the percentages of positive cells were measured. We have demonstrated binding of fluoresceinated substance P to all subsets examined, with significantly less binding to atopic dermatitis CD3-, CD8- and CD57-positive cells. This may affect cytokine release and hence be important in the pathogenesis of atopic dermatitis.
Topical calcitriol (1,25-dihydroxyvitamin D3) treatment of psoriasis: an immunohistological evaluation.
Authors: Reichrath J , Perez A , Müller SM , Chen TC , Kerber A , Bahmer FA , Holick MF.
Published: June 2023

The potent calciotropic hormone calcitriol (1,25-dihydroxyvitamin D3, 1,25(OH)2D3) has been shown to be very effective and safe in the topical treatment of psoriasis. In vitro, 1,25(OH)2D3 inhibits proliferation and stimulates differentiation of human keratinocytes. Increasing evidence suggests an immunoregulatory function of this potent steroid hormone. To further characterize the biological effects of topical calcitriol treatment in psoriasis, we have analyzed immunohistochemically the expression of markers for epidermal proliferation (proliferating cell nuclear antigen=PCNA) and differentiation (transglutaminase K, involucrin, cytokeratin 16), as well as inflammation (CD1a, 55 kDa TNF-receptor, NAP-1/IL-8) in calcitriol-treated psoriatic skin in situ. Our findings strongly support the hypothesis that calcitriol modulates keratinocyte proliferation/differentiation as well as inflammation in human skin in vivo. The immunoreactivity of markers for epidermal proliferation and differentiation, as well as of CD1a and NAP-1/IL-8, changed after 8 weeks of calcitriol treatment almost completely to the pattern characteristic for non-lesional psoriatic skin, while a large number of 55 kDa TNF-receptor positive cells could be found in the dermal compartment.
Stress and alopecia areata: a psychodermatologic study.
Authors: Gupta MA , Gupta AK , Watteel GN.
Published: June 2023

Psychosocial stress has been reported to play a role in the onset and/or exacerbation of alopecia areata. Little is known about the clinical characteristics of alopecia areata patients whose alopecia is stress-reactive. We examined the relation between the stress reactivity of alopecia areata and a wide range of psychosocial measures among 16 patients with alopecia areata/totalis and 28 patients with alopecia universalis. The degree to which the alopecia was exacerbated by stress was measured by patient ratings on a 10-point scale. A wide range of psychologic measures correlated (p
Cutaneous leukocytoclastic vasculitis in a case of ankylosing spondylitis.
Authors: Machet L , Jan V , Ouakil H , Vaillant L , Estève E , Lorette G.
Published: June 2023

No abstract available
Substance P is not involved in primary and secondary erythermalgia.
Authors: Drenth JP , Michiels JJ , Van Joost T.
Published: June 2023

No abstract available
"Complex regional pain syndrome" after trauma from high-heeled shoe.
Authors: Engelhart M , Bliddal H.
Published: June 2023

No abstract available
The simultaneous occurrence of Hailey-Hailey disease, Graves' disease and multiple sclerosis in the same patient.
Authors: Edwards Jr EK , Edwards Sr. EK
Published: June 2023

No abstract available
The skin and the gut in psoriasis: the number of mast cells and CD3+ lymphocytes is increased in non-involved skin and correlated to the number of intraepithelial lymphocytes and mast cells in the duodenum.
Authors: Michaëlsson G , Kraaz W , Hagforsen E , Pihl-Lundin I , Lööf L , Scheynius A.
Published: June 2023

The aim of this work was to study tryptase+ mast cells and CD3+ T lymphocytes in non-involved skin in psoriasis and their possible relation to mast cells and lymphocytes in the duodenal mucosa. Skin biopsy specimens were obtained from 43 patients with psoriasis of variable severity and from 10 healthy subjects. Compared with the reference subjects, the number of mast cells in non-involved skin was clearly increased, most markedly in the papillary dermis. The increase was present both in mild, moderate and severe psoriasis. CD3+ lymphocytes were increased in non-involved skin in moderate and severe psoriasis. Patients with an increased number of duodenal intraepithelial lymphocytes had significantly more mast cells in non-involved skin than those without such an increase, and there was a significant correlation between the number of mast cells in non-involved skin and score for intraepithelial lymphocytes. However, when the 14 patients with increased intraepithelial duodenal lymphocytes were excluded-as they may represent a separate type of psoriasis-another type of correlation between the skin and the duodenal mucosa was found, namely a highly significant inverse correlation between the number of CD3+ lymphocytes in non-involved skin and the number of duodenal mast cells, which is highly elevated in psoriasis. The results might indicate an interplay between skin and intestinal mast cells and lymphocytes in a hitherto unknown way.
Differences in extracellular matrix proteins, epidermal growth and differentiation in discoid lupus erythematosus, lichen planus and the overlap syndrome.
Authors: De Jong EM , Van der Vleuten CJ , Van Vlijmen-Willems IM.
Published: June 2023

Lichen planus (LP) and discoid lupus erythematosus (DLE) are separate disease entities. Nevertheless, patients with a so-called "overlap syndrome" have been described occasionally. The aim of the present study was to establish whether the LE/LP overlap syndrome, based on clinical and routine histological features, could be delineated from DLE or LP using immunohistochemical techniques. Formalin-fixated, paraffin-embedded skin biopsies of patients with DLE, LP and the overlap syndrome were compared regarding immunohistochemical markers for epidermal growth and differentiation and extracellular matrix components. With the markers for extracellular matrix proteins, it was possible to delineate the overlap syndrome from LP. This was not possible for the overlap syndrome and DLE. These findings might indicate that the LE/LP overlap syndrome could be considered as LP-like DLE rather than as a distinct disease entity.
Venous hemangioma. An immunohistochemical and ultrastructural study.
Authors: Ichikawa MM , Ishida-Yamamoto A , Hashimoto Y , Matsuo S , Iizuka H.
Published: June 2023

We present a case of (arterio) venous hemangioma of 15 years' duration, which arose in a 43-year-old Japanese man on his right infraorbital area. Elastic stain and electron microscopy did not show any evidence for arterial components. Some thick-walled vessels showed mucin deposition and wide intercellular spaces between smooth muscle cells. Several glomoid cells were encountered among these cells. Although the histogenesis of (arterio) venous hemangioma is controversial, the presence of glomoid cells and the mucin deposition, which is occasionally detected in glomus tumors, suggest the relation of this tumor to the Suquet-Hoyer canal.
Verrucous hemangioma.
Authors: Kawaguchi H , Kawaguchi T , Ishii N , Nakajima H , Ichiyama S.
Published: June 2023

No Abstract available
Stevens-Johnson syndrome after albendazole.
Authors: Dewerdt S , Machet L , Jan-Lamy V , Lorette G , Therizol-Ferly M , Vaillant L.
Published: June 2023

No Abstract available
White sponge naevus successfully treated with tetracycline mouth rinse.
Authors: Becker LR , Lutz C , Erbard H , Bröcker EB , Hamm H.
Published: June 2023

No Abstract available
Obituary: Professor Sture Lidén 1933-1997
Authors: Juhlin Lennart , Vahlquist Anders , Egelrud Torbjörn
Published: June 2023

No Abstract available
Non-invasive in vivo techniques to differentiate photodamage and ageing in human skin
Authors: Quan MB , Edwards C , Marks R.
Published: June 2023

It is important to differentiate skin changes due to the intrinsic ageing process from those due to chronic photodamage in the development of therapies to assist the latter condition, and in this study we have used instrumental techniques to differentiate between changes in a range of properties of skin due to ageing and those due to photodamage, especially with regard to elasticity. We measured three sites of differing sun exposure in a group of younger and in a group of older subjects. A pulsed A-scan ultrasound system was used to measure skin thickness,
Quantification and specificity of the repeated open application test (ROAT). A methodological study using cobalt and colophony in guinea pigs.
Authors: Wahlberg JE , Färm G , Lidén C.
Published: June 2023

The repeated open application test is used to assess the clinical relevance of positive patch test reactions to ingredients of formulated products. The great variation in outcome is usually claimed to be related to the concentration of the allergen responsible. We have here studied the quantitative aspects, specificity and effect of patch testing on the outcome of the repeated open application test in an animal model, using guinea pigs sensitized with cobalt chloride or colophony. Thresholds of sensitivity were determined before and after the topical treatments. Clear dose-response relationships were established. The reactivity in sham-treated controls and to the vehicles was minimal. The concordance between patch test results and outcome of the use tests was concentration-dependent and at low concentrations < 50%. The repeated open application test is a useful method, but some of the basic issues need further evaluation. This animal model will hopefully serve this purpose.
Upregulation of CD40 and CD40 ligand expression in IgE-associated cutaneous diseases.
Authors: Hermes B , Worm M , Nowak F , Kroczek RA , Stein H , Henz BM.
Published: June 2023

In order to better understand the immunological processes connected with IgE-associated cutaneous disease, we have examined the expression of CD40 and its ligand CD40L, required for the induction of IgE synthesis in B-cells, as well as of IgE and its receptors in various dermatoses (atopic dermatitis (AD), scabies, chronic recurrent urticaria) versus normal skin, and in one dermopathic lymph node versus normal lymphatic tissue by immunohistochemistry. Compared to normal skin, cells expressing IgE, Fc epsilon RI, Fc epsilon RII, CD40, CD40L and L26 were increased in the dermis, partly also in the epidermis, from patients with AD and scabies, but not in chronic urticaria. CD40 and CD40L were detected on numerous cells in lymphatic tissue from both normal donors and a patient with AD, whereas large numbers of IgE- and Fc epsilon RI-positive cells were only found in the dermopathic lymph node from the AD patient, in contrast to very few in normal lymphatic tissue. These results with selectively increased IgE/Fc epsilon RI and associated CD40/CD40L expression in the skin of AD and scabies suggest that cutaneous tissue, in addition to dermopathic lymphatic tissue, might contribute to IgE synthesis.
Sleep patterns in children with atopic eczema.
Authors: Bartlet LB , Westbroek R , White JE.
Published: June 2023

Following routine appointments in a paediatric dermatology clinic, the parents of 44 young children with atopic eczema and 18 with other skin conditions were interviewed regarding sleep patterns. Sleep disorders were more prevalent in the eczema children than in the control group and normal populations. "Night waking" problems were particularly common in the eczema children, whereas settling problems were not. An association was found between scratching habits and "night waking"--the more the children scratched, the greater the likelihood of their waking at night. Consideration is given to the management of the sleep problems of eczematous children.
Treatment of refractory cases of atopic dermatitis with acidic hot-spring bathing.
Authors: Kubota K , Machida I , Tamura K , Take H , Kurabayashi H , Akiba T , Tamura J.
Published: June 2023

The incidence of refractory atopic dermatitis has increased in teenagers and young adults. The purpose of this study was to control the skin symptoms of such patients in daily life. Seventy patients repeatedly took a 10-min 42 degrees C acidic hot-spring bath twice daily. The skin symptoms were improved in 76% of cases. In 30 of 42 responders examined Staphylococcus aureus, detected on the skin surface, disappeared or decreased through balneotherapy. In contrast, S. aureus remained unchanged in 8 of 10 non-responders examined. Thus, the balneotherapy using acidic hot-spring water may be useful for controlling the skin symptoms of acute flares of refractory cases of atopic dermatitis.
Morphology of endogenous flare-up reactions in contact allergy to gold.
Authors: Larsson A , Möller H , Björkner B , Bruze M.
Published: June 2023

In a double-blind study, 20 patients with contact allergy to gold were given an intramuscular injection of gold sodium thiomalate or placebo, inducing a clinical and histological flare-up of healed patch test sites in the gold-injected but not in the placebo group. The test area of the placebo group showed some perivascular lymphocytic foci (UCHL-1+) and vascular endothelial ELAM-1 staining. The gold group, with flare-up, showed larger and more extensive lymphocytic foci with ELAM-1+ endothelium as well as lymphocytic epidermotropism. CD1a+ LC cells were downgraded, tryptase+ mast cells accumulated and CD68+ monocytes/macrophages markedly increased. Probably, a significant part of the tissue priming as a result of patch testing comprises memory T-cells and endothelial ELAM-1 upgrading, but blood-borne CD68+ monocytes may also be instrumental in the flare-up.
Linear atrophoderma of Moulin.
Authors: Cecchi R , Giomi A.
Published: June 2023

No Abstract available
Cutaneous larva migrans detected by epiluminescent microscopy.
Authors: Elsner E , Thewes M , Worret WI.
Published: June 2023

No Abstract available
Lupus erythematosus as an occupational disease.
Authors: De Boer EM , Nieboer C , Bruynzeel DP.
Published: June 2023

No Abstract available
Atypical molluscum contagiosum--a diagnostic problem.
Authors: Ogg GS , Coleman R , Rosbotham JL , MacDonald DM.
Published: June 2023

No Abstract available
Local cholinergic urticaria at methacholine test site.
Authors: Kiistala R , Kiistala U.
Published: June 2023

No Abstract available
Deep dermal invasion of keratoacanthoma of the face.
Authors: Okuyama R , Rokugo M , Tagami H.
Published: June 2023

No Abstract available
Emergency Ultrasound: Hypoechoic Submucosa as Sign of Active Bowel Inflammation - Case Report
Authors: Vasin Dragan
Published: June 2023

Ultrasound is a radiological examination method that is often used in daily practice for the diagnosis of various abdominal conditions that can be very complex. Very often, patients present for an examination with non-specific abdominal pain accompanied by discrete changes in the stool, which can lead to diagnostic confusion in the case of a normal ultrasound finding in the abdomen. Many radiologists have minimal experience with bowel ultrasound outside of basic indications such as appendicitis and intususception and may be uncomfortable interpreting images for other diagnosis. In our paper, we present a case of ileitis in which the diagnosis was established by ultrasound findings of hypoechoic submucosa of the terminal ileum segment along the mesenteric edge. Submucosal hypoechogenicity of the ileum can be the only sign of primary inflammation of the ileum, but also a secondary ultrasound sign of appendicitis, while in our case hypoechogenicity of the submucosa was present only on the mesenteric side of the ileum, which enabled the initial diagnosis of ileitis and the initiation of conservative therapy. Bowel ultrasound is an important diagnostic procedure in the emergency department in cases of acute abdominal pain, which in a large percentage of cases enables the triage of these patients for surgical or medical treatment.
Different Tools Used for Treatment of Chronic Hepatitis B
Authors: Ukashah Muhamma
Published: June 2023

Currently different vaccines are available for cure and medicines are also available since 1988 but still 250 million people are infected with hepatitis B virus. The viruses of hepatitis B and hepatitis C causes liver cancer and also tuberculosis and malaria. The well developed and under developing countries both are very poor in care that can reduce the risk of hepatitis B. If we talk about United States only one third of those people who are infected with this virus are aware of their infection. The main reason for this un awareness is that the asymptomatic nature of hepatitis B virus as the symptoms are observed when it is at the chromic stage. The patients and care providers both lack knowledge regarding this disease. More attention has been focused from the previous 5 years in order to improve care linked to this disease, its proper diagnosis and proper care. There are also some novel compounds in trial phases to functionally cure this disease. There are also some professional organizations that provide knowledge and guidelines regarding this disease. These steps help those areas in which there is lack of knowledge regarding this disease and also they don’t have proper cure of this disease. The findings of global experts are used to fulfill the gap that is occurring in this regard.