bluuebunny/crossref_metadata_2025 huggingface dataset:
Operator Linear-2 Terbatas pada Ruang Bernorma-2 Non-Archimedean
Authors: Nurnugroho Burhanudin Arif , Supama Supama , Zulijanto A.
Published: May 2021

Di dalam paper ini dikonstruksikan operator linear-2 terbatas dari X2 ke Y , dengan X  ruang bernorma-2 non-Archimedean dan  ruang bernorma non-Archimedean. Di dalam paper ini ditunjukan bahwa himpunan semua operator linear-2 terbatas dari X2 to Y , ditulis B(X2, Y) merupakan ruang bernorma non-Archimedean. Selanjutnya, ditunjukan bahwa B(X2, Y), apabila Y ruang Banach non-Archimedean.

[In this paper we construct  bounded 2-linear operators from X2  to Y, where X is non-Archimedean 2-normed spaces and  is a non-Archimedean-normed space. We prove that the set of all bounded 2-linear operators from X2 to Y  , denoted by B(X2, Y) is a non-Archimedean normed spaces. Furthermore, we show that B(X2, Y) is a non-Archimedean Banach normed space, whenever Y is a non-Archimedean Banach space.]
Analisis Sistem Antrian dengan Simulasi di Puskesmas Cebongan Kota Salatiga
Authors: Muninggar Puput Retno , Linawati Lilik , Parhusip Hanna Arini
Published: May 2021

Tujuan dari penelitian ini adalah untuk mendapatkan model sistem antrian, mengetahui karakteristik sistem antrian, dan mendapatkan  hasil analisis simulasi pada sistem antrian di Puskesmas Cebongan Kota Salatiga. Pengumpulan data dilakukan dengan metode observasi langsung pada bagian Pendaftaran, bagian Cek Tekanan Darah dan bagian Periksa di Poliklinik Umum, dan bagian Pengambilan Obat. Hasil penelitian diperoleh masing-masing model antrian di bagian Pendaftaran, bagian Cek Tekanan Darah, dan bagian Pengambilan Obat adalah (G/G/1) : (FIFO/∞/∞), dimana waktu antar kedatangan dan waktu pelayanan berdistribusi general, jumlah server 1, disiplin antrian FIFO, kapasitas sistem dan kapasitas kedatangan yang tidak terbatas. Model antrian di bagian Periksa yaitu (G/G/2) : (FIFO/∞/∞), yaitu waktu antar kedatangan dan waktu pelayanan berdistribusi general, jumlah server 2, disiplin antrian FIFO, kapasitas sistem dan kapasitas kedatangan yang tidak terbatas. Kesesuaian hasil simulasi setiap pelayanan sudah mendekati kondisi nyatanya, namun pada bagian Cek Tekanan Darah dan Pengambilan Obat terdapat beberapa karakteristik yang belum sesuai dengan kondisi nyata. Hasil simulasi rata-rata jumlah pasien dalam antrian dan rata-rata waktu pasien dalam antrian pada bagian Cek Tekanan Darah dan bagian Pengambilan Obat lebih besar dari kondisi nyata.

[The purpose of this study are to obtain a queuing system model, find out the characteristics of the queuing system, and obtain the results of simulation analysis on the queuing system in Cebongan Health Center, Salatiga City. Data collection is done by direct observation method in the Registration section, the Blood Pressure Check section and the Check section in the General Polyclinic, and the Drug Collection section. The results of the study were obtained by each queue model in the Registration section, the Blood Pressure Check section, and the Drug Extraction section is (G/G/1) : (FIFO/∞/∞), where the time of arrival and service time are generally distributed, the number of servers 1, FIFO queue discipline, unlimited system capacity and arrival capacity. The queue model in the Check section is (G/G/2) : (FIFO/∞/∞), which is the time between arrival and general distribution service time, number of servers 2, FIFO queue discipline, unlimited system capacity and arrival capacity. The suitability of the simulation results for each service is close to the actual conditions, but in the Checking Blood Pressure and Drug Taking section there are several characteristics that are not in accordance with the real conditions. The simulation results of the average number of patients in the queue and the average time of patients in the queue at the Blood Pressure Check and Drug Extraction section are greater than the real conditions.]
Aplikasi Model Matematika Dua Predator dan Prey Terinfeksi dengan Kontrol Pestisida pada Penyebaran Hama Wereng Batang Cokelat di Kabupaten Bantul
Authors: Taufiq Irham , Agustito Denik
Published: May 2021

Penelitian ini bertujuan membentuk model matematika yang menunjukan interaksi antara predator dan prey dengan kontrol pestisida. Interaksi antara predator dan prey menggunakan fungsi respon Holling tipe II. Pertumbuhan predator dan prey menggunakan fungsi logistik. Dari Model tersebut diperoleh delapan titik ekuilibrium. Semua titik ekuilibrium tersebut dianalisis menggunakan metode linierisasi dan bersifat stabil asimtotik lokal. Kemudian model ini diaplikasikan dengan menggunakan data. Selanjutnya, simulasi numerik menggunakan software Maple untuk memprediksikan dinamika populasi wereng predator dan prey. Semua populasi tersebut akan bertahan hidup karena dipengaruhi oleh kontrol pestisida dan tingkat pemangsaan.

[This research aimed to construct a mathematical model showed the interaction between predator and prey by control of the pest. The interaction between predator and prey followed functional response Holling type II. The modeled population growth both predators and prey were using the logistic function. There were eight equilibrium points for this model. Each of them was linearization method analyzed and asymptotic stability. Then, this applicated model was using data. Then numerical simulation used software Maple to predict dynamical population both of them. All populations will survive because of control of pest and the level of interaction both of them.]
Modeling and Prediction of COVID-19 with a Large Scale Social Distancing
Authors: Adi Yudi Ari , Ndii Meksianis Z.
Published: May 2021

Coronavirus 2019 (COVID-19), yang kasusnya dimulai di Cina, dalam kurun waktu dua bulan telah menyebar dengan cepat ke lebih dari 114 negara dan territorial. Pemahaman tentang dinamika penularan Covid-19 sangat penting untuk menentukan kebijakan dan strategi dalam pengobatan dan pengendalian penyebaran penyakit ini. Dalam makalah ini, disusun model matematika yang menggambarkan dinamika penularan penyakit menggunakan model matematika deterministik dengan menggunakan data penyebaran COVID-19 di Jakarta, Indonesia dari 3 Maret 2020, hingga 10 April 2020. Model berbentuk Sistem persamaan diferensial yang selanjutnya dilakukan analisis matematika dan simulasi numerik. Hasil simulasi menunjukkan bahwa tanpa intervensi, angka reproduksi penyebaran Covid-19 di Provisi Jakarta sekitar 1,658 dan jika Pembatasan Sosial Berskala Besar (PSBB) diimplementasikan, maka angka reproduksinya turun menjadi 1,40. Lebih lanjut, epidemi diperkirakan akan berakhir sekitar akhir November 2020 dengan kasus puncak pada pertengahan Juni 2020 dengan jumlah orang yang dikonfirmasi positif terinfeksi mencapai sekitar 9.000 jiwa. Dari hasil pemodelan ini, disimpulkan bahwa untuk meminimalkan penularan penyakit, perlu menerapkan kebijakan dan kontrol yang lebih ketat.

[Coronavirus disease 2019 (COVID-19) which was initiated in China, has spread rapidly in more than 114 countries and territories over the last two months. An understanding of the dynamics of Covid-19 transmission is very important to determine policies and strategies in the treatment and control of the spread of this disease. In this paper, we formulated a mathematical model that describes the transmission dynamics of the disease using a deterministic mathematical model and the model is validated against data from Jakarta, Indonesia from March 3, 2020, to April 10, 2020. Mathematical analysis and numerical simulations are presented. We found that without intervention, the reproduction number is around 1.658 and the reproduction number declines to 1.40 if large scale social distancing is implemented. Furthermore, the end time of epidemic is predicted to be around the end of November 2020 with peak cases around mid-June 2020 and the number of confirmed infected individuals is around 9,000. To minimize the transmission of the diseases, it is necessary to enforce strict policies and controls.]
Pembentukan Portofolio Optimal dengan Menggunakan Mean Absolute Deviation dan Conditional Mean Variance
Authors: Vanti Eka Nur , Supandi Epha Diana
Published: May 2021

Penelitian ini membahas tentang pembentukan portofolio optimal menggunakan model Mean Absolute Deviation (MAD) dan model Conditional Mean Variance (CMV). Pada model MAD risiko portofolio diukur menggunakan rata–rata deviasi standar sehingga portofolio optimal dapat diperoleh dengan menggunakan pemrograman linear. Sedangkan portofolio model CMV, rata–rata return diestimasi menggunakan model Autoregressive (AR) dan risiko (variansi) diestimasi menggunakan model GARCH. Selanjutnya kedua model portofolio diterapkan dalam membentuk portofolio optimal pada saham–saham yang terdaftar dalam Indeks Saham Syariah Indonesia (ISSI) periode 4 Juli 2016 sampai 4 Juli 2018. Kinerja kedua portofolio dianalisis menggunakan indeks Sortino. Hasilnya menunjukan bahwa kinerja portofolio model CMV lebih baik dibandingkan model portofolio MAD.

[This study discusses the formation of optimal portfolios using the Mean Absolute Deviation (MAD) model and the Conditional Mean Variance (CMV) model. The MAD portfolio model measures portfolio risk by using average standard deviations so that optimal portfolios solved by using linear programming. Meanwhile the CMV portfolio model, the average return estimated by using the Autoregressive (AR) model and the risk (variance) estimated by using the GARCH model. Furthermore, both portfolio models applied in forming optimal portfolios for stocks listed in the Indonesian Syariah Stock Index (ISSI) for the period 4 July 2016 to 4 July 2018. The performance of both portfolios analyzed by using the Sortino index. The results show that the portfolio performance of the CMV model is better than MAD portfolio model.]
Development of a Guide to Preparation of Mathematics Questions Based on Higher Order Thinking Skills and Strengthening Character Education for Middle School Teachers
Authors: Ibrahim Ibrahim , Kuswidi Iwan , Arfinanti Nurul
Published: May 2021

The objectives of public devotion based on nationally excelled research this covers: (1) to develop a mathematical problem composing guide based on HOTS and SCE for qualified Madrasah Tsanawiyah teachers, (2) to provide training a mathematical problem composing based on HOTS and SCE for qualified Madrasah Tsanawiyah teachers using the developed guide. This study uses a 4-D (Four D) development research design model according to Thiagarajan, et al (1974: 5). This research model includes 4 main stages, namely the defining stage, followed by the design stage, then towards the development stage, and finally the distribution phase. The research instruments included: (a) the scale of the assessment of the quality of mathematical composing guide based on HOTS and SCE for Madrasah Tsanawiyah teachers, (b) scale of appraisal user response for guidebook, and (c) the Pre Test and Post Test Problem Sheets. The results of the study concluded that the guidebook for mathematical problem composing for SMP / MTs based on HOTS and SCE met the specified quality criteria, which were at least in the good category. In this study, the developed guidebook obtained an evaluation in the excellent category. However, testing to determine the level of practicality has not been done.
Analisis Perkembangan Fasies Dan Lingkungan Pengendapan Pada Interval Formasi Kujung Dan Tuban, Blok West Tuban, Cekungan Jawa Timur
Authors: Saerina Anisa Nevi , Kurniasih Anis , Setyawan Reddy
Published: May 2021

Cekungan Jawa Timur merupakan cekungan hidrokarbon yang telah terbukti menghasilkan minyak bumi dengan reservoir utama yaitu pada Formasi Kujung dan Tuban. Tujuan penelitian ini adalah mengetahui variasi litologi, distribusi litologi secara lateral, fasies dan lingkungan pengendapan berdasarkan asosiasi litologi serta perkembangan terumbu yang berkaitan dengan perubahan muka air laut. Metode yang digunakan dalam penelitian ini adalah analisis kualitatif menggunakan data sumur berupa wireline log. Analisis kualitatif menggunakan software Paradigm Geolog 7.0 untuk mendeterminasi litologi. Langkah selanjutnya, menganalisis dan membuat permodelan fasies, lingkungan pengendapan dan sikuen stratigrafi.Berdasarkan hasil analisis Formasi Kujung dan Tuban terdiri dari 4 jenis litologi yaitu batugamping, batulempung, batulanau dan batupasir. Setelah dilakukan analisis fasies, formasi tersebut terdiri dari 4 fasies yaitu patch reef core, patch reef flank, off-mound near reef dan off-mound. Patch reef pada daerah penelitian dicirikan dengan litologi batugamping energi rendah diendapkan pada bagian rongga antar koloni terumbu, menghasilkan asosiasi skeletal wackestone – packstone. Lingkungan pengendapan terumbu berada pada platform terisolasi akibat segmentasi basement berarah timurlaut – baratdaya. Perubahan muka air laut Formasi Kujung dibagi menjadi yaitu TST-1 dan HST-1, kemudian dilanjutkan dengan TST-2 saat pengendapan Formasi Tuban. Fase transgresi awal terumbu tumbuh dengan fase catch up, pada fase high stand terumbu tumbuh dengan fase keep up dan pada saat transgresi kedua terumbu sebagian tetap berkembang sebagai keep up dan sebagian lainnya mengalami give up.
The cost of screening radiographs after stable fracture fixation
Authors: Tufescu Ted
Published: May 2021

Background: Currently up to 58% of Canadian surgeons would forego screening radiographs after stable fracture fixation. It is therefore expected that reducing screening radiographs will be well accepted, provided that patient safety is not compromised, resulting in a cost reduction. The study objective was to measure the savings of a simplified radiographic protocol for well-fixed fractures and establish feasibility for a noninferiority trial that proves patient safety. Methods: Patients were randomized after fixation. The control group received screening radiographs immediately after fixation and at 2 weeks. The experimental group received radiographs only when clinically indicated. At 6 weeks all patients received radiographs. The cost of imaging, time spent in clinic and patient satisfaction was measured. A blinded reviewer documented adverse events, either detected or missed. Results: Of the 90 patients screened, 39 were randomized and 26 had complete follow-up. The mean cost of radiographs over the first 6 weeks was $44.51 (95% confidence interval [CI] 38.64–50.38) per patient in the experimental group, and $129.23 (95% CI 120.23–138.23) in the control group (p < 0.001). The mean time spent in clinic at 2 weeks was 46 min (95% CI 32–60) per patient for the experimental group and 68 min (95% CI 55–81) for the control group (p = 0.018). Two complications occurred in the experimental group. Both were detected clinically and did not qualify as missed events. Conclusion: Implementing a simplified radiography protocol after stable fracture fixation saves time and money. Additionally, no adverse events were missed with the study protocol. Recommendations are made toward a noninferiority trial to establish protocol safety.
Development of Ceramic and Glass Fiber Needle-Punched Nonwoven Fabrics Part I: An Optimization
Authors: Prabu K. , Srinivasan J. , Prakash C.
Published: May 2021

The study on the performance of areal density of web, needle punching density, and needle depth of penetration, particularly, the combination of glass and ceramic fiber nonwoven fabrics over the mechanical, thermal, and filtration properties were studied with the Box-Behnken experimental design. For the requirement of filtration behavior, three sets of samples with varying glass fiber areal densities of 250, 300, and 350g/m2 were taken and added with ceramic fibers to achieve sandwich-blend nonwoven materials of 60/40, 50/50, and 40/60 ratios. Then, the processing variables were taken as needle punch density and needle depth of penetration, and three optimized samples were predicted using the Box-Behnken experimental design based on the filtration efficiency of the exhaust along with their mechanical and thermal properties. It is also found that there was significant influence on the properties by the variables taken for the product development for the filters. It was found that there was a significant increase in the tensile properties in the optimized samples, and it was found that the results taken for the optimization process were unaltered.
No Detectable Effect on Visual Responses Using Functional MRI in a Rodent Model of α-Synuclein Expression
Authors: Østergaard Freja Gam , Skoven Christian Stald , Wade Alex R. , Siebner Hartwig R. , Laursen Bettina , Christensen Kenneth Vielsted , Dyrby Tim B.
Published: May 2021

Parkinson’s disease (PD) is a progressive neurodegenerative disease that is typically diagnosed late in its progression. There is a need for biomarkers suitable for monitoring the disease progression at earlier stages to guide the development of novel neuroprotective therapies. One potential biomarker, α-synuclein, has been found in both the familial cases of PD, as well as the sporadic cases and is considered a key feature of PD. α-synuclein is naturally present in the retina, and it has been suggested that early symptoms of the visual system may be used as a biomarker for PD. Here, we use a viral vector to induce a unilateral expression of human wild-type α-synuclein in rats as a mechanistic model of protein aggregation in PD. We employed functional magnetic resonance imaging (fMRI) to investigate whether adeno-associated virus (AAV) mediated expression of human wild-type α-synuclein alter functional activity in the visual system. A total of 16 rats were injected with either AAV-α-synuclein (n = 7) or AAV-null (n = 9) in the substantia nigra pars compacta (SNc) of the left hemisphere. The expression of α-synuclein was validated by a motor assay and postmortem immunohistochemistry. Five months after the introduction of the AAV-vector, fMRI showed robust blood oxygen level-dependent (BOLD) responses to light stimulation in the visual systems of both control and AAV-α-synuclein animals. However, our results demonstrate that the expression of AAV-α-synuclein does not affect functional activation of the visual system. This negative finding suggests that fMRI-based read-outs of visual responses may not be a sensitive biomarker for PD.
Neuron Replating, a Powerful and Versatile Approach to Study Early Aspects of Neuron Differentiation
Authors: Schneider Felix , Duong Thuy-An , Rust Marco B.
Published: May 2021

Neuron differentiation includes formation and outgrowth of neurites that differentiate into axons or dendrites. Directed neurite outgrowth is controlled by growth cones that protrude and retract actin-rich structures to sense environmental cues. These cues control local actin filament dynamics, steer growth cones toward attractants and away from repellents, and navigate neurites through the developing brain. Rodent hippocampal neurons are widely used to study the mechanisms underlying neuron differentiation. Genetic manipulation of isolated neurons including gene inactivation or reporter gene expression can be achieved by classical transfections methods, but these methods are restricted to neurons cultured for several days, after neurite formation or outgrowth. Instead, electroporation allows gene manipulation before seeding. However, reporter gene expression usually takes up to 24 h, and time course of gene inactivation depends on the half live of the targeted mRNA and gene product. Hence, these methods do not allow to study early aspects of neuron differentiation. In the present study, we provide a detailed protocol in which we combined electroporation-based gene manipulation of mouse hippocampal neurons before initial seeding with a replating step after 2 din vitro(DIV) that resets neurons into an undifferentiated stage. By categorizing neurons according to their differentiation stage, thorough morphometric analyses, live imaging of actin dynamics in growth cones as well as guidance cue-mediated growth cone morphologic changes, we demonstrate that differentiation and function of replated neurons did not differ from non-replated neurons. In summary, we provide a protocol that allows to thoroughly characterize differentiation of mouse primary hippocampal neurons.
Sounding the Grind
Authors: Armstrong Stephen
Published: May 2021

Battles in Japanese role-playing games (JRPGs) present special problems for game immersion because of their sheer ubiquity and repetitiveness. This is particularly true of games that require the player to “grind”—that is, to engage in repetitive fights in order to level-up characters and thereby gain tactical advantages later. This paper argues that battle music is first and foremost a variety of functional music, a genre that fans measure not by its sonic beauty but by its psychological effectiveness. This point leads directly to a number of pressing questions: How do battle themes function? How do these functions relate to the all-important concerns of immersion and interactivity? How do we evaluate the effectiveness of battle music? And finally, what would a preliminary theory of battle music composition look like?

This article examines how the grind of JRPG fighting manifests as an integral part of battle music composition, analyzing three standard conventions in detail: (1) a clear opening audiovisual rupture, (2) a fanfare as cadence, and (3) a sustained period of harmonic stasis underpinning busy surface textures. This last phenomenon creates a sense of “musicospatial stasis”—that is, a musically induced sense of stasis that intermingles with and projects itself onto the visual and narrative fields. Because the repetitive grind of JRPG battles interrupts movement through the overworld, battle themes should be understood as ruptures in the sonic environment, just as the battle stage is a spatial rupture in the overworld. Battle themes therefore make little sense as analytical objects out of context: by definition, they signal a break that impedes the player’s movement throughout a larger environment.
Kill the Orchestra
Authors: Freitas Joana
Published: May 2021

In the age of participatory and convergence paradigms, video game music has its own networked culture with cybercommunities that discuss, share, and create content, thus opening up a creative space for artistic activities in a constant digital flow. Music composition and production is one of these activities, with files made available on several platforms such as SoundCloud and YouTube, specifically in the format of modification files (or mods). Building on research for a master’s dissertation, this article examines a new model of online artistic production in the form of the circulation of musical mods that were composed and shared on the Nexus Mods platform for the The Elder Scrolls IV: Oblivion and The Elder Scrolls V: Skyrim video games. These mods add new musical material that is similar to the existing soundtrack of both titles, but the majority of the files in this platform’s audio category are related only to sounds, not to musical composition. By using titles such as “better sounds” or “immersive sounds” to describe their additions, many modders aim to give other gamers a more immersive experience in the game(s). In this case, immersive relates not only to the musical style and sound quality of the aural effects but also a plausible construction of the reality in which the gamers live, play, and negotiate meaning relating to their own social context. Intersecting “playbour,” fandom, aural immersion, and audiovisual literacy, these audio modders work on adding new layers to the soundscapes and environments of the virtual worlds presented in the two games. The modders regard immersion as a key aspect of design and playability, and they contribute audio material to enable their social capital and visibility on online platforms.
Voices, Combat, and Music
Authors: Smith Jennifer
Published: May 2021

Role-playing video games can highlight a sense of player identification with a pre-made player-character through the inclusion of the voice; this can include diegetic character dialogue, the non-diegetic sung voice, and voice-overs. Ensuring that the player can connect with their player-character on an individual level is key to forming a suspension of disbelief and immersion with a game.

Final Fantasy XV emphasizes collaboration between the player, player-characters, and non-playable characters during combat, cutscenes, and exploration. This camaraderie effect actively engages the player with multiple characters through the constant use of the diegetic spoken voice to communicate between the player-character, Noctis, and the three other character identities, Prompto, Ignis, and Gladiolus. The game’s opening rendition of Ben E. King’s “Stand by Me,” performed by Florence + the Machine, provides the player with four narrative themes that are present throughout the game. These themes include a coming-of-age story, character relationships, and the development of a greater evil within the narrative. Unique in its position as a pre-composed song, “Stand by Me” plants the idea that the player will not be alone in their journey, as character allies will stand by Noctis, from the beginning of the game.

Final Fantasy XV uses vocalizations in both the diegetic and non-diegetic audio space in order to reflect the characteristics of the playable characters. The vocal relationship between the player’s characters provides directional feedback and information for the player within combat, alongside foretelling the stories of certain characters.
Music and Sound in Virtual/Augmented Realities—Questions, Challenges and Approaches
Authors: Summers Tim , Cook James , Famer Will , Ferrè Elisa Raffaella , Harrison Lucy , Hemming Rich , Ivănescu Andra , Reed Luke , Roberts Flossie , Stevens Richard , Tatlow Stephen , Whittaker Laryssa
Published: May 2021

The mid-to-late 2010s saw a renewed interest in virtual reality technologies with the release of a wide selection of consumer VR headsets and glasses, and the increased power of smartphones to provide augmented reality experiences. While research on sound and music in these technologies has started to gather pace, practice and research continue to grapple with significant creative and practical questions. In addition, such discussions have tended to be limited within disciplinary or professional silos. The roundtable presented here was an effort to begin conversations across a variety of fields of research and practice. We shared perspectives and exchanged views informed by different disciplinary traditions and experiences. We also sought to identify key questions and issues regarding music and sound in VR/AR. Three main themes are presented here: 1) Spaces and musical performances, 2) Realities and realism, and 3) Movement, orientation, and disorientation.
Series: Cardiovascular outcome trials for diabetes drugs Semaglutide and SUSTAIN-6
Authors: Fisher Miles
Published: May 2021

SUSTAIN-6 (Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes) was a pre-licensing FDA-mandated cardiovascular outcome trial with subcutaneous semaglutide and was the first completed trial with a once-weekly glucagon-like peptide-1 receptor agonist. SUSTAIN-6 compared semaglutide and placebo in 3,297 people with type 2 diabetes and established cardiovascular disease, chronic kidney disease, or both, or who were aged over 60 years and had subclinical evidence of cardiovascular disease (persistent microalbuminuria or proteinuria, hypertension with left ventricular hypertrophy, left ventricular dysfunction by imaging, ankle/brachial index less than 0.9). As SUSTAIN-6 was performed as a pre-licensing safety study, non-inferiority for major cardiovascular events (MACE; cardiovascular death, non-fatal myocardial infarction, non-fatal stroke) was the primary outcome and testing for superiority for MACE was not pre-specified or adjusted for multiplicity. SUSTAIN-6 confirmed non-inferiority for MACE, with nominal superiority, and demonstrated a significant reduction in the risk of non-fatal stroke. There was no significant difference in non-fatal myocardial infarction, cardiovascular death, all-cause mortality or hospitalisation for heart failure. Rates of retinopathy complications were unexpectedly higher in the semaglutide group. Further outcome trials with subcutaneous semaglutide are in progress, including a cardiovascular outcome trial in non-diabetic subjects with overweight or obesity.
Kaštelina – vila obitelji Bebija
Authors: Jurković Miljenko , Turković Tin
Published: May 2021

Rad je osvrt na rezultate dosadašnjih istraživanja na poluotoku Kaštelina na otoku Rabu. Poslije dovršenih četiriju arheoloških kampanja, rad je prvi pokušaj kontekstualizacije prikupljenih podataka, a koji se odnose u najvećemu dijelu na antičku fazu organizacije života na poluotoku. Istraživanja su pokazala da se na vrhu poluotoka nalazila antička vila čije je dvije faze izgradnje moguće datirati u 1. stoljeće n. e., pa čak i povezati s nadgrobnim spomenikom obitelji Bebija pronađenim nedaleko vile.
Nove spoznaje o korskim sjedalima u crkvi Uznesenja Blažene Djevice Marije u Rabu
Authors: Škarić Ksenija , Gjini Vanesa
Published: May 2021

Istraživanja kasnogotičkih korskih sjedala koja je Hrvatski restauratorski zavod proveo 2018. godine u župnoj crkvi, negdašnjoj katedrali Uznesenja Blažene Djevice Marije u Rabu upućuju na postupan tijek gradnje klupa koji se odvijao u fazama, a dovršen je 1445. godine. Pored oblikovnih i tehničkih sličnosti između zadarskih i rapskih korskih sjedala, pripisanih rezbarskoj radionici Mateja Moronzona, na njima su zamijećene znatne razlike u koncepciji polikromije. Od dovršetka gradnje do danas korska sjedala u Rabu najmanje su dvaput planski preinačena. Obnova u drugoj polovini 17. stoljeća osobito je zanimljiva kao pokušaj modernizacije pojednostavljenjem oblika i uvođenjem novih elemenata koji su uvjerljivo integrirani. Kasnije preinake trajno su ostale istaknute kao strano tijelo.
Morske i planinske kolonije: prilog istraživanju javnozdravstvenih ustanova u razdoblju međuraća u Rijeci i regiji
Authors: Lozzi Barković Julija
Published: May 2021

U članku se arhitektonski i sadržajno analiziraju kompleks dječje morske kolonije Villa Italia na Costabelli, obalnom potezu između Rijeke i Opatije, i planinska kolonija IX. Maggio na Učki, reprezentativni primjeri javnozdravstvenih ustanova realiziranih u razdoblju međuraća na području Kvarnerske provincije koja je tada u sastavu Kraljevine Italije. Osim uz more i na planinama, kolonije su se mogle nalaziti i uz rijeke i jezera te u urbaniziranim središtima. Postojale su dnevne, privremene i stalne kolonije, a svaka je imala svoje osobitosti. Njihov program i djelovanje bili su pod ingerencijom vladajućeg fašističkog režima u suradnji s državnim i lokalnim administrativnim tijelima. Projektanti morske kolonije Villa Italia i planinske kolonije IX. Maggio, unatoč snažnom političkom i ideološkom pritisku, u stvaranju novih arhitektonskih vrijednosti dali su vlastiti doprinos, postigavši visoku razinu moderniteta na području međuratne javnozdravstvene izgradnje u lokalnom i nacionalnom okviru.
„U njegovim rukama i velika se umjetnost pretvara u kič” L. Giesz
Authors: Srhoj Vinko
Published: May 2021

Slučaj Dimitrija Popovića nakon velike petdesetljetne retrospektive u zagrebačkim Klovićevim dvorima uputio je i na finale trivijalizacije jednog opusa koji je obećavao veliku maniru i relevantan sadržaj na početcima kada još nije bilo potrebe za grotesknom nadrealizacijom u društvu estradizacije. Dorflesovski rečeno, Popovićevo je slikarstvo s vremenom u istu ravan dovelo Salomu i Severinu, Kristovo tijelo, „prikazano u simbolu kruha koji je narezan na kriške ili Madonu koje se fizička ljupkost pretvara u rafinman izgleda nekog foto-modela.” Dimitrije bira dramu egzistencije i velike teme u nadi da će one odraditi posao za sebe, to jest pukim izborom, primjerice, sadržaja iz Dantea ili Leonarda, postati velikom umjetnošću. To je ona vrsta lijenosti duha, onaj gemütlichkeit koji proizvodi, kako bi rekao A. Moles „komfor srca” kopiranjem jezika prošlosti, kao da je umjetnost prijelazna i da je samo dovoljno biti u njezinoj blizini i za njom posegnuti pa da i sami postanemo dijelom njezine veličine. No ipak će biti, kako kaže L. Giesz opisujući kiččovjeka nalik na Dimitrija, da se „u njegovim rukama i velika umjetnost pretvara u kič.”
Nepoznati Ecce Homo Nikole Lazanića u Italiji
Authors: Tulić Damir
Published: May 2021

Nikola Lazanić, rodom s Brača, najvažniji je kasnorenesansni kipar u Hrvatskoj. Njegov skulptorski opus broji svega tri signirana djela. Najranija je reljefna kamena pala iz 1578. s prikazom Bogorodice s Djetetom sa svetim Petrom i Pavlom u crkvi Svetog Petra u Nerežišću na Braču. Majstor je od 1581. do 1584. zabilježen u Rimu, a 1589. u Dubrovniku gdje za staru crkvu gradskog patrona radi svoja dva antologijska kipa, svetog Vlaha i svetog Jeronima. Nikola se bavio i slikarstvom pa je 1591. uzeo šegrta kojem se obavezao da će ga idućih deset godina poučavati kiparstvu i slikarstvu. Zadnji majstorov spomen je potpisana oltarna pala naslikana 1593. za Chiesa dei Carmini u Bitontu. U članku se objavljuje nepoznata kamena bista s prikazom Krista ovjenčanog trnovom krunom – Ecce Homo. Nalazi se izvan izvornog konteksta u vrtu župne kuće u mjestu Noventa Padovana u istočnom predgrađu Padove. Na poprsju je majstorov potpis: NICvs . LASANEVS . F. Skulptura se hipotetski datira u deveto desetljeće 16. stoljeća, kada se pretpostavlja i majstorov boravak u Veneciji, odnosno Venetu. Također, upućuje se na mogući slikovni predložak za ovo Lazanićevo djelo, odnosno na grafiku nastalu prema Tizianovu liku Ecce Homo, a koja je tiskana u Veneciji u trećoj četvrtini 16. stoljeća.
Destrukcija i zaborav kao kritički (motivirajući) faktor u baštini: spomenici kao mjesta odsutnosti
Authors: Uskoković Sandra
Published: May 2021

Dobar dio autora i teoretičara koji se bave baštinom i memorijom tvrdi da je organizirani zaborav u velikoj mjeri prisutan u društvu, pa bismo, shodno tomu, mogli zaključiti da svako društvo svjesno zaboravlja. Nositelji ili izvršitelji projekta zaborava često nastoje izbrisati čitavo sjećanje „neprijatelja” destrukcijom baštine čime se želi prisiliti one koji ih baštine i čuvaju da ih zaborave. U ovom članku nastojat ću uputiti na to da povijesni artefakti sačinjavaju dio procesa društvenog zaborava što ujedno otvara i sljedeće pitanje-temu: može li se povijest konstruirati i rekonstruirati iz povijesti amnezije, a ne povijesti memorije? Proces „suočavanja s gubitkom, tj. destrukcijom” u baštinskoj je praksi i politici još uvijek u povojima i češće se odnosi na priznavanje problema nego na sam odgovor na problem. Paradigma spasitelja koja prožima baštinski diskurs je fundamentalno utemeljena na sustavu koji podjednako implicira žrtvovanje i gubitak manje vrijednih kulturnih ostvarenja nasuprot zaštiti i konzervaciji više vrijednih ostvarenja. Ova pitanja i dileme su fundamentalno politički i svode se na odluku: koje priče/objekte očuvati, slaviti i zapamtiti, a koje zaboraviti? Objašnjavajući pojmove destrukcije i zaborava na primjerima porušenog Zadra, splitskog Peristila, Starog mosta u Mostaru i, naposljetku, antifašističkih spomenika, pokušala sam uputiti i utvrditi da i mjesta odsutnosti mogu biti mjestima memorije, te da je baština po svojoj prirodi performativna. Povijesne građevine, naime, nisu same po sebi inherentno smislene i bitne, već postaju važne samo onda kad su društveno konstruirane kroz performativni čin.
Crtica za crkvicu: Sv. Nikola u vali Dražanica ispred Zadra
Authors: Vežić Pavuša
Published: May 2021

Članak govori o crkvi Sv. Nikole u vali Dražanica ispred gradske luke u Zadru. O njoj svjedoči povijesni izvor iz 14. stoljeća i fotografija snimljena početkom 20. stoljeća. U arhivskome izvoru zapisanom 3. svibnja 1383. godine zabilježeno je da će majstor Marko pokojnoga Marka popraviti crkvu Sv. Nikole u Dražanici, ecclesiam s. Nicolai ad Drachssiniçam. Crkva je unekoliko starija, a nalazila se na ulazu u valu uza samo more. Snimljena je 1912. ili 1913. godine. Tada se još čuvala u prostoru, premda u ruševnome stanju. Odlike arhitekture upućuju na srednjovjekovno razdoblje. Ipak, nije poznato kada je izgrađena, kao ni kada je posve razorena.
Josip Vaništa kao „lažni Rimbaud”
Authors: Župan Ivica
Published: May 2021

Tekst potvrđuje zagrebačku protokonceptualnu skupinu Gorgona kao antiestetsko i antislikarsko društvo, koje nastoji inicirati reviziju zatečene umjetnosti, desakralizirati umjetničko stvaranje, sekularizirati umjetničko djelo i njezinu poruku. Protegnula se Gorgona u prostor mentalne slobode i demistifikacije samog jezika umjetnosti. U gorgonaškim rukopisima stvarnost likovnog djela pregnantno i dojmljivo nastupa kao nešto samostalno i samodostatno, slobodno od tradicionalnih, kanoniziranih, propisanih i akademiziranih navada predstavljačkog slikarstva. Kritičko preispitivanje funkcije umjetnosti i umjetničkog jezika otkrilo je gorgonašima konvenciju slike kao neprimjerenu etici umjetnosti. Slikanje – sada doživljeno kao zastarjeli i potrošeni instrument umjetničke ekspresije – nastoji se svesti na minimum, a zapravo ga – konceptualno – nastoje izbaciti iz konteksta umjetničkog, premda si članovi grupe – izvan gorgonaških aktivnosti – dopuštaju i slikanje. Gorgonaši afirmiraju bihevioralnu i verbalnu poziciju umjetnika, pa se o mediju „čistog” slikarstva može govoriti tek u kontekstu njegove negacije. Rad posebice predstavlja antislikarske radove Josipa Vanište kojima nadilazi i nadvladava pojam slike, pretvarajući je u tekst.
La rencontre de la littérature sud-slave avec les littératures étrangères: Alberto Fortis et Charles Nodier
Authors: Delibašić Spomenka
Published: May 2021

Notre objectif est d’étudier la question des différentes influences des littératures occidentales sur la littérature des Slaves du Sud ainsi que le mode de transmission et de propagation des chants populaires dans les deux sens. Nous nous proposons d’aborder une approche imagologique et interculturelle méthodologiquement ouverte qui accorde la priorité absolue aux textes d’Alberto Fortis et de Charles Nodier en questionnant les fonctions de l’altérité, l’etude des représentations de l’autre, alter et alius. La transmission orale de la matière épique française sur le territoire des Slaves du Sud était importante : le thème de Roland a pénétré en Dalmatie par l’intermédiaire de l’Ombrie (Banašević, 1975, 8). Le thème poétique de «Hasanaginica» («Triste ballade de la noble épouse d’Asan-aga»), le premier texte de la littérature de la côte orientale de l’Adriatique traduit en français a excité la curiosité et éveillé l’intérêt du public français aux chants populaires des Slaves du Sud. Ce chant «morlaque» est publié par Alberto Fortis dans l’original avec une traduction italienne dans Viaggio in Dalmazia (1774). La version de Goethe de ce chant célèbre contribue à la valorisation de la poésie des peuples balkaniques en Allemagne d’abord, puis dans d’autres pays d’Europe. On peut constater que la haute valeur poétique des chants populaires de cette région du Sud marque dans les littératures occidentales un cheminement parallèle et se prêtent un mutuel appui.
Rede anlässlich der Vorstellung der Zeitschrift GEM
Authors: Müller-Funk Wolfgang
Published: May 2021

Rede anlässlich der Vorstellung der Zeitschrift GEM
Gedanken zur Taufe
Authors: Krassnigg Anna Maria
Published: May 2021

Rede anlässlich der Vorstellung der zeitschrift GEM am 14. Oktober 2019 in der Österreich-Bibliothek „Dr. Alois Mock“ an der Universität Zadar
Varijabilnost padalina na području Hrvatske s maritimnim pluviometrijskim režimom
Authors: Maradin Mladen
Published: May 2021

Rad se bavi varijabilnošću padalina u dijelu Hrvatske s maritimnim pluviometrijskim režimom. Varijabilnost padalina analizirana je korištenjem godišnjih i mjesečnih vrijednosti srednje relativne varijabilnosti za 18 postaja od 1950. do 2007. godine. Utvrđeno je da godišnja varijabilnost padalina ima relativno veliki raspon – najveću varijabilnost padalina ima postaja Lastovo, a najmanju postaja Parg. U godišnjem hodu varijabilnosti padalina glavni maksimum varijabilnosti je na području sjevernog Jadrana u listopadu, dok se prema jugu maksimumvarijabilnost javlja u ljetnim mjesecima – srpnju ili kolovozu. Glavni minimum varijabilnosti u većini postaja s maritimnim pluviometrijskim režimom javlja se u travnju, osim na postajama srednjeg Jadrana, gdje se javlja u studenom. Najmanju varijabilnost padalina ima područje Gorske Hrvatske u gotovo svim mjesecima. Najveće vrijednosti varijabilnosti padalina javljaju se ljeti na području južnog Jadrana. U gotovo svim mjesecima varijabilnost padalina na području Kvarnera je relativno viša u odnosu varijabilnost padalina okolnih postaja.
Comparative analysis of the spatial organisation of the Catholic Church on the Croatian Adriatic coast. Changes after World War II and perspectives for its future reorganisation
Authors: Kajinić Josip
Published: May 2021

This paper outlines the changes in the organisation of the Catholic Church in Istria, Kvarner and Dalmatia after World War II. A detailed analysis of the circumstances that lead to the establishment of the Rijeka Diocese, Archdiocese and Metropolitan Archdiocese, ecclesiastical union of the Istrian region in Croatia, the abolition of the Zadar Metropolitan Archdiocese, the raising of the Split-Makarska Diocese to an Archdiocese, and the establishment of the Split Metropolitan Archdiocese. The principles upon which the Church reorganisation in the spatial sense are considered, and presents new insights, particularly for the Croatian dimension. The second part of the paper gives a comparative analysis of the spatial organisation of the Catholic Church on the Croatian coast of the Adriatic Sea, with other countries. Examples were selected based on compatibility of different factors, with consideration to the historical context of events and their causes. To that aim, specific examples of the church administration in France and Italy are given. Using these examples and documents of church archives and official records and documents of the Catholic Church, this paper gives a final overview of the possibilities for the reorganisation of the church administration on the Croatian Adriatic coast.
PROJEKCIJE KRETANJA ROMSKE POPULACIJE U MEĐIMURJU – PUT OD MANJINE KA VEĆINI
Authors: Šlezak Hrvoje , Belić Tomislav
Published: May 2021

Rad analizira recentna nacionalno diferencijalna obilježja prirodnog kretanja, dobne strukture i promjena u fertilnom kontingentu stanovništva Međimurske županije. Rezultati analize i projekcije kretanja romske populacije upućuju na započet proces promjene nacionalne strukture Međimurske županije u smislu povećanja udjela pripadnika romske nacionalne manjine i smanjenja udjela većinskog

stanovništva. Analizirani pokazatelji upućuju na intenziviranje započetog procesa i značajne promjene u nacionalnoj strukturi Međimurske županije u budućnosti.
Ecoregion: contours of the concept
Authors: Voyloshnikova Daria
Published: May 2021

By now, ecosystemic regionalisation has gone through several decades of conceptual development and localised application. Yet, it remains multiform and ‘open to interpretations’, both in theory and practice. The article contributes to accommodating ecoregion in social sciences and humanities. To that effect, proceeding from a review of specialised literature, it outlines the essence of ecoregional approach and formulates and discusses the key characteristics of the concept ‘ecoregion’ (vague definitions, holistic capture, systemic nature, and manageability). It then presents ecoregion as one of the ideas underlying a wider environmental governance setting in the Adriatic area.
Intrinzična motivacija i samoefikasnost srednjoškolaca na satovima tjelesne i zdravstvene kulture
Authors: Cetinić Jelena , Vidaković-Samaržija Donata
Published: May 2021

The research was conducted on the sample of 251 high school students of Medical School in Zadar (63 respondents were male and 188 were female, aged 15-18). Two questionnaires were used. The first one referred to general self-efficiency (after Schwarzer et al., 1997) and it included 10 items that measure general and stable sense of self-efficacy in facing different stressful situations. The second questionnaire referred to intrinsic motivation (Intrinsic Motivation Inventory/IMI/, after McAuley, Duncan & Tamman, 1989, adapted to physical education in 2002, after Barić et al.) and it included 18 items that evaluated four factors: a) interest/pleasure; b) perceived competence; c) effort/importance; d) pressure/tension. The analysis included calculation of the frequency of replies and calculation of descriptive indicators in both questionnaires. Application of t-test for independent samples showed that there was statistically important difference between males and females in the level of self-efficacy that the students achieve in physical education classes. The analysis also showed differences in the level of motivation, i.e. there were statistically significant differences between sexes related to the following factors: interest/pleasure, perceived competence, and pressure/tension. On the other hand, there were no significant differences related to effort/importance factor.
Suvremeno iseljavanje Hrvata: kakva je budućnost Republike Hrvatske?
Authors: Jerić Marijana
Published: May 2021

Republiku Hrvatsku kroz povijest je zahvatilo nekoliko velikih iseljeničkih valova. Posljednji val iseljavanja započeo je pristupanjem Republike Hrvatske Europskoj uniji 2013. godine, a traje i danas. Razvijene zemlje Europske unije poput Njemačke, Austrije i Irske postale su glavno odredište hrvatskih iseljenika u potrazi za boljim životom. Cilj ovoga istraživanja je utvrditi stvarno stanje o broju iseljenih Hrvata iz Republike Hrvatske, usporediti podatke sa službenom statistikom Republike Hrvatske te dati zaključak o mogućim posljedicama iseljavanja. Rezultati istraživanja pokazuju da se iseljavanje hrvatskih državljana ne može pratiti prema službenim podacima Državnog zavoda za statistiku jer oni nisu usklađeni sa statističkim podacima zemalja emigracije, odnosno broj prijavljenih hrvatskih doseljenika veći je u prosjeku za 62 % od službenih podataka Republike Hrvatske. Prognoze budućih migracija hrvatskih državljana upućuju na gubitak 20 % stanovništva u sljedećih trideset godina zbog čega je već sada potrebno razvijati nove ekonomske, mirovinske, obrazovne i ostale politike koje utječu na demografske promjene.
Appropriate expression of P57kip2 drives trophoblast fusion via cell cycle arrest
Authors: Song Hong-Lan , Liu Tai-Hang , Wang Yong-Heng , Li Fang-Fang , Ruan Ling-Ling , Adu-Gyamfi Enoch Appiah , Hu Si-Chen , Chen Xue-Mei , Ding Yu-Bin , Fu Li-Juan
Published: May 2021

The syncytiotrophoblast, derived from cytotrophoblast fusion, is responsible for maternal–fetal exchanges, secretion of pregnancy-related hormones, and fetal defense against pathogens. Inadequate cytotrophoblast fusion can lead to pregnancy disorders, such as preeclampsia and fetal growth restriction. However, little is known about the mechanism of cytotrophoblast fusion in both physiological and pathological pregnancy conditions. In this study, P57kip2 (P57), a cell cycle-dependent kinase inhibitor that negatively regulates the cell cycle, was found to be up-regulated during the process of syncytialization in both primary trophoblast cells and BeWo cells. Co-immunofluorescence with proliferation markers Ki67 and Cyclin-CDK factors further showed that P57 specifically localizes in the post-mitotic cytotrophoblast subtype of the early pregnancy villi. Overexpression of P57 promoted trophoblast syncytialization by arresting the cell cycle at the G1/G0 phase and inhibiting proliferation. Blocking of the cell cycle through a serum starvation culture resulted in an enhancement of cytotrophoblast fusion and the up-regulation of P57. In both spontaneous cytotrophoblast fusion and forskolin-induced BeWo cell fusion models, an initial up-regulation of P57 was observed followed by a subsequent down-regulation. These findings indicate that proper expression of P57 at cytotrophoblast differentiation nodes plays an important role in trophoblast syncytialization.