bluuebunny/crossref_metadata_2025 huggingface dataset:
Locating Nepalese Mobility: A Historical Reappraisal with Reference to North East India, Burma and Tibet
Authors: K. C. Gaurab , Kharel Pranab
Published: August 2020

Most literature published on migration in Nepal makes the point of reference from 19th century by stressing the Lahure culture - confining the trend’s history centering itself on the 200 years of Nepali men serving in British imperial army. However, the larger story of those non-military and non-janajati (ethnic) Nepali pilgrimages, pastoralists, cultivators and tradesmen who domiciled themselves in Burma, North East India and Tibet has not been well documented in the mobility studies and is least entertained in the popular imagination. Therefore, this paper attempts to catalog this often neglected outmigration trajectory of Nepalis. Migrants venturing into Burma and North East India consist of an inclusive nature as the imperial army saw the overwhelming presence of hill janajatis in their ranks whereas Brahmins (popularly known as Bahuns) and Chettris were largely self-employed in dairy farming and animal husbandry. In tracing out the mobility of Nepalis to North East, Burma and Tibet it can be argued that the migrating population took various forms such as wanderers (later they became settlers), mercantilist, laborers, mercenary soldiers, and those settlers finally forced to become returnees. In this connection, documenting lived experiences of the living members or their ancestors is of paramount importance before the memory crosses the Rubicon.
Bangladesh’s Take on Restoring the Parliamentary Control over the Judiciary: New Course through the 16th Amendment to the Constitution
Authors: Udin Syed Morshed Rahad
Published: August 2020

Shortly after its emergence as a nation through a historic struggle for national liberation, Bangladesh formed its constitution in 1972. Since its formation in 1972, the Constitution of Bangladesh has been amended many times. The latest addition to that amendment list is the 16th amendment of the constitution that was endorsed from the parliament on 17th September 2014. The 16th amendment of the constitution brought back an old provision of the impeachment process of Supreme Court judges of Bangladesh replacing Article 96 of the constitution of Bangladesh. Since the passing of the 16th amendment in the parliament of Bangladesh, it has been a hot topic to be discussed under constitutional law. This short article embodies a critical analysis of the 16th amendment of the constitution and an opinion regarding the very issue.
Gender Specific English Advertisements
Authors: Arakelyan Ruzanna , Petrosyan Ani
Published: August 2020

Advertising is a worldwide phenomenon nowadays that has gained the attention and interest of a large number of individuals in different societies around the world. Advertising is not only an “ideal tool” for reaching people economically, but also a device of attaining and maintaining contact with people socially, culturally, politically and even psychologically. As men and women perceive various social phenomena and often react to certain situations in quite distinct ways, it is also vividly expressed in the ways they perceive the effectiveness of advertising language. This is also conditioned by the fact that men and women create different imagery from the advertisements they see. This confirms the fact that ad specialists should analyze how they choose the target viewers and what language they should use to focus on them. Thus, gender is one of the main segmentation variables for the advertiser, and a significant factor that makes it interesting to advance the study of how gender differences are manifested in the language of advertisements.
EXPLORATION OF THE CONCEPT OF SADYOVAMANA
Authors: Jasminbegam Bashirahmad Momin  , Prasad V. Kulkarni  , Vishwas E. Gogate
Published: August 2020

Ayurveda is a comprehensive natural health care system. This ancient science explains the Shodhana Chikitsa for complete elimination of root cause of the disease. Vamana is the first among Panchakarmas which is used as Shodhana Chikitsa in which Kapha pradhana Utklishta Doshas are expelled out through oral route. Ayurvedic classics have described the details about scientific approach of Vamana Karma. The only drawback of this therapy can be mentioned as it is a very time consuming procedure which is quite difficult every time for every Rugna. Some conditions also arise where implementation of Vamana in scientific manner is not possible as the situation demands for quick elimination of Doshas. At this time, Sadyovamana helps in quick and instant relief of complaints of patient. This concept of Sadyovamana can be used as an emergency management of Atyayika Avasthas depending upon the Utklishta Doshas. This article aims to review the concept of Sadyovamana, its variance from classical Vamana and its indications in order to explore the emergency management of diseases from Ayurvedic Samhitas.
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF MANNICH BASES CONTAINING MORPHOLINE MOIETY
Authors: D.Alekhya  , A.Lakshmana Rao  , D.Prasanth  , D.V.S.Girija Sowmya  , Ch.Vijaya Lakshmi  , Ch. Raja
Published: August 2020

A variety of morpholine derivatives as mannich bases were prepared through mannich reaction by reacting 4-nitro acetophenone as compound containing active hydrogen, substituted benzaldehyde and morpholine as secondary amine compound. All the synthesized compounds structures were characterized by physical analysis data and spectral analysis data (IR and 1H-NMR spectral analysis). The newly synthesized compounds were evaluated for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa in comparision with standard drug Streptomycin. However the antibacterial activity of the synthesized compounds against the tested organisms was found to possess good to moderate activity.
The Effect of Inflation and Murabaha on Profitability with NPF as an Intervening Variable
Authors: Effendi Bahtiar
Published: August 2020

This study aims to determine the effect of inflation, murabaha on the profitability of BPRS mediated by Non Performing Financing (NPF). This study uses quantitative methods and data analysis using Path Analysis with the help of WarpPls 5.0 test tool. Data sources are secondary data obtained from the official website of Bank Indonesia and the Sharia Banking Statistics Report. The results showed that: (1) Inflation did not affect the profitability of BPRS (2) Murabaha financing negatively affect the profitability of BPRS; (3) NPF has a negative effect on profitability of BPRS; (4) Inflation has no effect on NPF of BPRS; (5) Murabahah has a positive effect on NPF of BPRS; (6) NPFs can not mediate the inflation and profitability relationship of the BPRS; (7) NPF mediates the murabahah and profitability of BPRS
PEDAGOGIA FEMINISTA E CURRÍCULO ESCOLAR
Authors: LIMA Rosangela de Araújo
Published: August 2020

Aborda-se nesse trabalho a importância da discussão sobre gênero nos currículos escolares na visão da Pedagogia Feminista, tendo como objetivo analisar a contribuição dos pressupostos teóricos feministas para a constituição de um Currículo Escolar inclusivo. O método de investigação utilizado neste estudo foi de caráter bibliográfico, alicerçado na discussão e no mapeamento da produção acadêmica sobre o tema. Reitera-se, então, a importância ímpar dessa discussão e da adoção de uma proposta pedagógica amparada nos pressupostos da Teoria Feminista para a consecução de uma escola democrática e cidadã, onde a diversidade humana seja não só respeitada, mas acolhida de forma que vise à inclusão escolar e social dos sujeitos. A Escola ainda hoje exclui e atua numa perspectiva da norma heterocêntrica.
Culminación de estudios: Una propuesta integradora en la Educación Superior
Authors: Cruz Rizo Lorna , Matos Hernández Eneida Catalina
Published: August 2020

Dadas las dificultades en el proceso de culminación de estudios en Educación Superior, los estudios teóricos y prácticos desarrollados resultan sorprendentemente escasos. Históricamente, ha existido una limitada cantidad de estudiantes que sustentan sus tesis de grado después de completar créditos en la Escuela de Lenguas y Lingüística de la Universidad de Guayaquil. Consecuentemente, el problema de esta investigación es: insuficiencias en el proceso de culminación de estudios en relación con la gestión de la formación de los estudiantes. Por tanto, devino objetivo el perfeccionar la culminación de estudios para la obtención del título universitario, a través de la implementación de una propuesta praxiológica de integración entre la formación académica y la investigación formativa. La sistematización de experiencias de las autoras dinamizó la metodología utilizada. La modelación de la gestión curricular de la integración entre la formación académica y la investigación formativa se reveló como el aporte principal y solución al problema detectado. Como resultados obtenidos, los estudiantes solucionaron problemas educativos diagnosticados, a la vez que diseñaron la primera versión de sus tesis. Se logró así perfeccionar cualitativa y cuantitativamente este proceso. Esta propuesta puede ser generalizable a cualquier proceso de culminación de estudios a través de tesis de grado.
La Documentación en ATRESMEDIA: tecnología y recursos humanos al servicio de la producción de contenidos
Authors: López de Quintana Sáenz Eugenio
Published: August 2020

Con tres millones de horas en sus fondos, sistemas de gestión propios, un servicio externalizado y medio millón de transferencias anuales de imágenes realizadas, el archivo del Grupo ATRESMEDIA está diseñado para la máxima integración en los circuitos de producción de todos los canales y empresas del Grupo. Junto a las funciones tradicionales de selección, tratamiento documental e intermediación en la búsqueda de imágenes, el departamento está bien posicionado para una progresiva transformación del perfil profesional del documentalista de televisión hacia una mayor implicación en la producción del contenido audiovisual, apoyado en el uso de herramientas de inteligencia artificial, ya en explotación.
Noticias B&D
Authors: López de la Fuente Elena
Published: August 2020

Noticias del área de Biblioteconomía y Documentación
Miradas plurales, realidades comunes
Authors: Arango Zuleta Elvia Patricia
Published: August 2020

Los llamados insistentes a considerar las singularidades humanas permean las prácticas, los procesos, las configuraciones organizacionales y toda institucionalidad, lo que de entrada confirma el estrecho vínculo individuo sociedad, por lo tanto, no se trata de juzgar si hay perspectivas mejores que otras sino que la pretensión es reconocer algunas maneras como son atendidas, solventadas y potenciadas las cualidades de las personas y de las realidades donde se concretan; asimismo, tener un acercamiento a las inquietudes que subyacen en las búsquedas de explicación de acontecimientos sociales y culturales, susceptibles de ser problematizados y transformados. Para hacerlo, se reflexiona desde una perspectiva pragmática algunos nexos entre contradicciones, resistencias y posibilidades, al igual que entre lenguaje, contexto y experiencia, y entre valores, sociedad e institucionalidad.
La educación religiosa escolar como acción educativa, evangelizadora y catequética, parte ii
Authors: Valencia Rodríguez William Alberto
Published: August 2020

Como se afirmó en la primera parte (n.º 11 de Kénosis) en este artículo se presentan avances de la investigación Enfoque bíblico-espiritual del documento conclusivo de Medellín en sus 50 años; consta de tres partes, la primera ya expuesta (referencia a algunas fuentes que subyacen en el documento de Medellín que pueden servir elementos para comprender el acto educativo y los Estándares que presenta la Conferencia Episcopal de Colombia (2017) para la enseñanza del área de Educación Religiosa (ERE) y se avanzó en la segunda sección (algunas posibles implicaciones pastorales expuestas en el Documento de Medellín que se pueden articular al área de ERE como acciones complementarias de formación catequética). En el apartado actual se culmina la parte dosy se concluye con los desafíos del momento: posibilidades, valores y condiciones. Con esta organización se busca señalar una relación con las tres áreas abordadas durante la Segunda Conferencia del Episcopado Latinoamericano: promoción del hombre y de los pueblos hacia los valores de la justicia, la paz,la educación y la familia; necesidad de una adaptada evangelización y maduración en la fe de los pueblos y sus élites, a través de la catequesis y la liturgia; los problemas que requieren intensificar la unidad y acción pastoral. Se pretende inferir en el documento de Medellín orientaciones que iluminen la misión de la escuela, centrada en la formación integral más que en la instrucción de las futuras generaciones.
Perilaku Pemilih di Kecamatan Jagakarsa, Jakarta Selatan dalam Pemilihan Gubernur/Wakil Gubernur DKI Jakarta Tahun 2017
Authors: Emka Odeles Kirawan
Published: August 2020

Abstrak

Pemilihan Gubernur dan Wakil Gubernur DKI Jakarta tahun 2017 lalu, sebagaimana diketahui telah memunculkan pasangan Anies-Sandi sebagai pemenangnya dan sah memimpin DKI Jakarta sampai dengan tahun 2022. Pasangan Anies-Sandi unggul atas pasangan Ahok-Djarot yang sebelumnya memimpin DKI Jakarta. Peristiwa politik tersebut secara nyata telah menimbulkan dinamika politik yang sangat tinggi. Namun demikian perlu kiranya untuk melihat perilaku pemilih terkait dengan Pilkada DKI Jakarta 2017 yang tersebut. Dalam penulisan ini akan di lihat perilaku pemilih di Wilayah Kecamatan Jagakarsa. Perilaku pemilih ini akan diihat dari pendekatan sosiologis, psikologis dan pilihan rasional.

 

Kata Kunci : Pilkada DKI Jakarta 2017, Perilaku Pemilih, Demokrasi

 

Abstract

The election of the Governor and Deputy Governor of DKI Jakarta in 2017, as is known, has raised the Anies-Sandi pair as the winner and is legitimate to lead DKI Jakarta until 2022. The Anies-Sandi pair is superior to the Ahok-Djarot pair who previously led DKI Jakarta. These political events have significantly led to very high political dynamics. However, it is necessary to look at voter behavior related to the 2017 DKI Jakarta Regional Election. In this paper we will look at voter behavior in the Jagakarsa District Area. This voter behavior will be seen from a sociological, psychological and rational choice approach.

 

Keywords: 2017 DKI Jakarta Election, Voter Behavior, Democracy
Makna Penting Keberadaan Komunitas Politik keamanan Asean Dalam Menyelesaikan Konflik Kawasan
Authors: Saragih Hendra , Yani Yanyan M
Published: August 2020

Abstract

            This paper seeks to emphasize that ASEAN's strategic position in the Southeast Asian region, which has never used military and armed forces in resolving conflicts between members of ASEAN or outside ASEAN Members and this is ASEAN's greatest achievement in regulating peaceful interactions within the region. The development and formation of the ASEAN security posture in the form of a Security Political Community are certainly expected to play a large role in the framework of becoming the forefront of ASEAN in the effort to improve relations that have been torn apart by the conflict and to re-knit it to be more peaceful and set an example for other regions.

Keywords: Regional Security, Effectiveness, region, Conflict

 

 

Abstrak

Makalah ini berupaya menegaskan bahwa posisi strategis ASEAN di kawasan Asia Tenggara yang tidak pernah menggunakan kekuatan militer dan bersenjata dalam menyelesaikan konflik baik antar sesama anggota ASEAN ataupun di luar Anggota ASEAN dan ini merupakan prestasi terbesar ASEAN dalam mengatur interaksi damai di dalam kawasan. Pembangunan dan pembentukan postur keamanan ASEAN yang berbentuk Komunitas Politik keamanan tentunya diharapkan akan banyak berperan dalam rangka menjadi garda terdepan ASEAN dalam upaya memperbaiki relasi-relasi yang sudah tercabik akibat konflik yang pernah terjadi dan merajutnya kembali agar lebih damai dan menjadi contoh bagi kawasan lainnya.
Kata Kunci : Keamanan Regional,Efektifitas,kawasan,Konflik
Studi Persuasi: Analisis Terhadap Kampanye Kementerian Kesehatan “Cegah, Obati, Lawan Diabetes” Melalui YouTube
Authors: Permatasari Yunita , Bernadette Sophia , Kusumawardhana Indra
Published: August 2020

Abstract

 

This article carries out an in-depth analysis of the campaign activity "Prevent, Treat, Fight Diabetes" uploaded by the Ministry of Health on YouTube as a form of government efforts in carrying out a persuasion of the public. Weighing efforts to strengthen public awareness of the prevention of the disease. The main question that will be asked is how can the persuasion efforts of the Ministry of Health through the "Prevent, Treat, Fight Diabetes" Campaign uploaded on YouTube affect the recipients of the message being communicated? To answer this question, this article uses the Elaboration Likelihood Model persuasion analysis model popularized by Richard E Petty and John T Cacioppo. Using qualitative research methods that use descriptive analysis and in-depth interviews, the results of this study are expected to be able to provide a comprehensive picture of the government's efforts to persuade people in certain goals.

 

Keywords: Persuasi, Pemerintah, Kampanye, Diabetes Mellitus, YouTube

 

 

 

 

 

 

 

 

 

Abstrak

 

Artikel ini melakukan analisis mendalam terhadap aktifitas kampanye “Cegah, Obati, Lawan Diabetes” yang diunggah oleh Kementerian Kesehatan di YouTube sebagai suatu wujud upaya pemerintah dalam melakukan suatu persuasi terhadap masyarakat. Menimbang upaya untuk menguatkan kesadaran masyarakat terhadap pencegahan penyakit tersebut. Pertanyaan utama yang akan diajukan adalah bagaimana upaya persuasi Kementerian Kesehatan melalui Kampanye “Cegah, Obati, Lawan Diabetes”yang diunggah di YouTube dapat memengaruhi penerima pesan yang dikomunikasikan? Untuk menjawab pertanyaan tersebut, artikel ini menggunakan model analisis persuasi Elaboration Likelihood Model yang dipopulerkan oleh Richard E Petty dan John T Cacioppo. Menggunakan metode penelitian kualitatif yang menggunakan analisis deskriptif dan in depth interview, Hasil dari penelitian ini diharapkan mampu memberikan gambaran komprehensif dari upaya pemerintah dalam melakukan persuasi terhadap masyrakat dalam tujuan-tujuan tertentu.

Keywords: Persuasi, Pemerintah, Kampanye, Diabetes Mellitus, YouTube
التنمية البشرية في ضوء مقاصد القرآن الكريم
Authors: Alzyoud Ahmad
Published: August 2020

الملخص:
تمثل التنمية البشرية اتجاهاً تنموياً تقدمياً، فقد انتقل الفكر التنموي نهاية القرن الماضي من التركيز على النمو والبناء الاقتصادي إلى التنمية البشرية التي تستهدف الإنسان وتأهيله للإنتاج، والعمل على تحقيق عدالة التوزيع وصون حقوق الإنسان وغيرها. ولكن كل ذلك جاء متأخراً، فقد وصل التضخم والبطالة والفقر مستويات قياسية، وفقدت الدول قدرتها على تحقيق الحد اللائق من العيش الكريم. توصل البحث إلى أسبقيّة الإسلام في السعي نحو التنمية البشرية من خلال المقاصد ذات العلاقة في القرآن الكريم، مع الإشارة إلى بعض النماذج التطبيقية في الإسلام.
الكلمات المفتاحية: التنمية البشرية، الفكر التنموي في الإسلام، القرآن الكريم
أثر استخدام المستحدثات التكنولوجية على تنمية مهارات اللغة الإنجليزية (القراءة، والاستماع، والقواعد) لدى طلاب الصف التوجيهي (الثاني عشر) في المملكة الأردنية الهاشمية
Authors: Al-Jarrah Firas
Published: August 2020

الملخص:
هدفت الدراسة إلى التعرف على أثر استخدام المستحدثات التكنولوجية على تنمية مهارات اللغة الإنجليزية (القراءة، والاستماع، والقواعد) لدى طلاب الصف التوجيهي (الثاني عشر) في المملكة الأردنية الهاشمية ، وقد أستخدم الباحث منهجين بحثيين مختلفين وهما المنهج الوصفي التحليلي الذي تم استخدامه في استقراء الأدبيات الخاصة بالمتغير المستقل والمتغير التابع، والمنهج التجريبي لقياس المتغير المستقل (المستحدثات التكنولوجية)، وتكونت عينة الدراسة من طلاب الصف التوجيهي (الثاني عشر) في المملكة الأردنية الهاشمية، وقد تم اختيارهم عشوائياً، موزعين على مجموعتين الأولى مجموعة تجريبية تم تدريسها باستخدام برنامج تعليمي قائم على استخدام المستحدثات التكنولوجية، والأخرى مجموعة ضابطة تم تدريسها بالطريقة التقليدية. صمم الباحث اختبار تحصيلي تكون من (30) سؤالا، في الفصل الدراسي الأول من العام 2019-2020، وقد أظهرت نتائج الدراسة أن هناك أثر في استخدام المستحدثات التكنولوجية لدى طلاب الصف التوجيهي في المملكة الأردنية الهاشمية، وذلك بتفوق المجموعة التجريبية على نظيرتها المجموعة الضابطة في الاختبار التحصيلي.
الكلمات المفتاحية: أثر، المستحدثات التكنولوجية، مهارة القراءة ، مهارة الاستماع، الصف التوجيهي (الثاني عشر).
WATER: ISLAM NORMS AND SCIENCES
Authors: Kamil Iksan Sahri
Published: August 2020

Classic Moslem scholars discussed the water on starting chapters in their books. It is shown how important the water in Moslems attention as a basic need that Moslem must know. The water in Islam can be disputed in two terms. First, in the ecology perspective, second, in the mahdhah ritual perspective.  In the first one, the concept imagines the water as a basic condition for life being and human as khalifah Allah fi al-Ardh. This contains ecology perspective. And the other one is for ritual condition in Islam ethic (ilm al-fiqh). Ilm al-fiqh or Islam ethic said that the water is a basic material for removing hadath (forbidden situation for taking Islamic mahdhah ritual) and cleaning najasat (the dirty materials in shariah perspective). In other hand, sciences make a new way to understand Al-quran and al-sunnah as a new interpretation of Al-quran specially in nature and all creations in universe and ritual activity in sciences prespective
Relevansi Konsep Uang Dalam Perspektif Ibnu Khaldun terhadap Kebijakan Moneter Indonesia
Authors: Hadi Sholikul , Romli Moh.
Published: August 2020

Money is part of the community's need to conduct various transactions. Indonesia as a developing country makes the dollar as the standard of money value because the position of the dollar is considered strong by almost all countries in the world. But in fact the existence of a dollar that is not guaranteed by anything often changes (fluctuates) and will directly affect the financial systems of countries that refer to the dollar, including Indonesia. Ibn Khaldun was a Muslim scientist who lived during the decline of Islam. He was actively involved in the world of government and was one of the figures who had brilliant ideas about the concept of money (751-808 H / 1350-1406 AD). This study aims to examine Ibn Khaldhun's concept of money and monetary policy in the economy and the relevance of his thinking to monetary policy in Indonesia. This research uses library research design (Library Research) with a historical and descriptive approach. The data collection technique chosen is the documentation technique, namely the data collection technique by examining relevant literature with the chosen title. In the analysis phase content analysis techniques are used and combined with historical continuity methods to answer the problem formulation that is proposed. The data analysis stage is through the stages of linguistic analysis and concept analysis. The results showed that: 1) the emergence of the concept of Ibn Khaldun's money and monetary system in the economy was motivated by the economic and political conditions experienced during Ibn Khaldun's life. History says that Muqadimah Ibn Khaldun was written based on the results of his thoughts combined with life experiences he experienced; 2) The concept of Ibn Khaldun is relevant if it is applied in the monetary system in Indonesia. This is based on the real conditions faced by Indonesia, which currently uses empty money. Even though its existence is now proven to have caused crises many times. So it is not impossible if gold and silver coins are used as the standard of money value.
Seroprevalence of hepatitis A virus, hepatitis B virus, hepatitis C virus, and syphilis among human immunodeficiency virus-infected people at a university hospital, Turkey
Authors: Can Bilek Heval , Deveci Aydın , Aksakal Tanyel Esra
Published: August 2020

Introduction

Infections such as viral hepatitis and syphilis that share similar transmission routes with human immunodeficiency virus (HIV) may adversely affect the course of the disease. We aimed to determine the seroprevalence of viral hepatitis and syphilis among HIV-infected people at the initial stage of diagnosis.

Material and methods

The medical records of 336 HIV-infected people aged 18 years and older, who were followed up between 2005 and 2018 at a university hospital in Samsun, Turkey, were evaluated retrospectively in terms of initial serological markers for viral hepatitis and syphilis.

Results

Hepatitis B surface antigen (HBsAg) was positive in 13 (4.2%) of 303 patients, antibody to HBs antigen (anti-HBs) in 117 (39.2%) of 298 patients, antibody to hepatitis C virus (anti-HCV) in 3 (0.9%) of 301 patients, total antibody to hepatitis B core antigen (anti-HBc total) in 70 (29.2%) of 239 patients and total antibody to hepatitis A virus (anti-HAV total) in 224 (84.5%) of 265 patients. Hepatitis B virus (HBV) deoxyribonucleic acid (DNA) was detected in one (12.5%) of eight patients with isolated anti-HBc. Of 224 patients who were examined for syphilis, 34 (15.1%) were positive for Treponema pallidum hemagglutination (TPHA).

Conclusions

In our study, high seroprevalence of syphilis and low immunity to HBV were detected. Health care facilities that follow up HIV-infected people should determine the serological profiles initially once the patients are diagnosed. It should be kept in mind that due to behavioral risk factors among HIV-infected people prevalence of coinfections may be higher than the rate in the community.
PRMT5, regulated by lncRNA ZFAS1/miR-150-5p, promoted androgen-independent prostate cancer migration and invasion
Authors: Shen Hao , Wang Lei , Zhang Ling , Weng Xiao-Dong , Yang Du , Liu Xiu-Heng
Published: August 2020

Introduction

Prostate cancer (PCa) is the most common male genitourinary malignancy in the world. The protein arginine methyltransferase 5 (PRMT5) is one of the main members of the type II PRMT family, which was reported to regulate androgen-dependent PCa cell proliferation. However, the upstream regulators of PRMT5 and its effects on androgen-independent PCa metastasis remained unclear. In the present study, we investigated whether PRMT5 could be a novel diagnostic marker and be used as a therapeutic target in PCa, to explore the possible molecular mechanism, and to understand the clinical importance of PRMT5 in PCa.

Material and methods

The present study evaluated PRMT5 expression levels in PCa and normal prostate samples using public datasets, including TCGA, GEPIA and GSE21032. Furthermore, CCK-8 assay, flow cytometer assay, and transwell assay were conducted to detect the roles of PRMT5. Luciferase reporter assay was used to determine the relationship among ZFAS1/miR-150-5p/PRMT5.

Results

Our results showed that PRMT5 was overexpressed in PCa samples. PRMT5 significantly promoted androgen-dependent PCa proliferation and cell cycle progression and suppressed cell apoptosis. However, PRMT5 did not affect androgen-independent PCa proliferation but it could significantly induce androgen-independent PCa metastasis. Knockdown of PRMT5 suppressed, whereas overexpression of PRMT5 induced, cell migration and invasion in androgen-independent DU145 and PC-3 cells. Moreover, our results showed that the ZFAS1/miR-150-5p axis regulated PRMT5 expression in PCa cells. Furthermore, the study showed that ZFAS1 and PRMT5 were overexpressed and miR-150-5p was down-regulated in PCa samples. Higher expression levels of ZFAS1 and PRMT5 were correlated with shorter disease-free survival time in PCa patients.

Conclusions

These results showed that PRMT5 may be a therapeutic target for PCa.
Polyether antibiotics K-41A and K-41Am inhibit
HIV-1 replication via suppressing the activities of HIV-1 reverse transcriptase and integrase
Authors: Liu Xin , Chu Jiemei , Gui Chun , Liao Weibo , Qin Fengxiang , Hu Xi , Liang Bingyu , Jiang Junjun , Huang Jiegang , Ning Chuanyi , Chen Jiang , Ju Jianhua , Lai Jingzhen , Liu Jie , Zhou Bo , Ye Li , Liang Hao
Published: August 2020

Introduction

K-41A is a known compound with antibacterial activity against gram-positive bacteria and coccidia. In our screening of anti-HIV compounds, we found polyether antibiotic K-41A and its analogue K-41Am isolated from a marine-derived Streptomyces sp. SCSIO 01680 exhibited anti-HIV activity.

Material and methods

In this study, we characterised the anti-HIV activity of K-41A and K-41Am as well as the mechanism(s) involved. The dose-dependent inhibitory effects of K-41A and K-41Am on HIV-1 replication were observed in the TZM-bl-HIV-1IIIB system, MT-2-HIV-1IIIB system, and peripheral blood mononuclear cells (PBMCs)-HIV-1BaL system. The 50% inhibitory concentrations (IC50) of K-41A on HIV-1 replication in three systems were 0.75 µM, 0.09 µM, and 0.13 µM, respectively, and the selective indexes (SIs) were 5.81, 49.44, and 598.00, respectively. The IC50 of K-41Am in three systems were 5.57 µM, 0.24 µM, and 1.15 µM, respectively, and the SIs were > 1.04, 80.71, and > 5.03, respectively.

Results

Mechanism research demonstrates that two compounds inhibited the activities of HIV-1 reverse transcriptase (RT) and integrase (IN) in a dose-dependent manner. Molecular docking shows that the docking scores were relatively high between the compound and HIV-1 RT or IN.

Conclusions

K-41A and K-41Am possess anti-HIV-1 activity via a multi-target inhibition mechanism, which provides a novel molecular pattern for anti-HIV drug design and structural modification to improve the anti-HIV activity.
Evaluation of plantar fascia using high-resolution ultrasonography
in clinically diagnosed cases of plantar fasciitis
Authors: Aggarwal Purnima , Jirankali Vivek , Garg Sudhir K.
Published: August 2020

Purpose

The aim of this study was to assess the efficacy of high-resolution ultrasonography in the assessment of plantar fascia in individuals with heel pain, before and after treatment.

Material and methods

This study was conducted from 2016 to 2019, during which time 44 clinically diagnosed patients of plantar fasciitis were compared to 50 normal volunteers. There were 25 males and 25 females in the control group and 42 females and two males in the study group. Thirty-eight patients had unilateral disease, and six patients had bilateral disease. The thickness of the plantar fascia was measured just anterior to its calcaneal attachment using ultrasonography. Body mass index (BMI) was also calculated in both groups.

Results

The plantar fascia was 2-4 mm thick in the control group whereas it was > 4 mm thick in 48 heels in the study group. With cut-off of > 4 mm as diagnostic of plantar fasciitis, this study had a sensitivity of 96%, specificity of 100%, and accuracy of 98%. BMI was increased in 60% of female patients. All patients were treated with local infiltration of corticosteroid. In 37/42 patients (43 heels) who had improved clinically, the thickness of plantar fascia was reduced to < 4 mm when assessed after six weeks of corticosteroid injection.

Conclusions

Diagnosis of plantar fasciitis can be easily verified by ultrasonography with plantar fascia thickness > 4 mm being suggestive of plantar fasciitis. Ultrasound can also be used to evaluate treatment response. Ultrasono­graphy helps the clinician in confirming the diagnosis of plantar fasciitis and also in assessing the response to treatment.
Effects of robot-assisted gait training with active motion visual feedback induced by guidance force on walking speed in patients with chronic stroke: a pilot study
Authors: Yoon Mu-Hong , Oh Duck-Won
Published: August 2020

Introduction

This study aimed to determine the effects of robot-assisted gait training with active movement visual feedback induced by guidance force on walking speed in patients with chronic stroke.

Methods

A single-subject reversal (A-B) design was applied. overall, 3 patients with chronic stroke underwent robot-assisted gait training with visual feedback displaying active motion of the affected lower limb during the intervention phase. Walking function was measured by using the 10-m walk test (10MWT) and peak knee flexion angle (PKFA) during walking.

Results

during the intervention phase, the 10MWT score of subjects 1, 2, and 3 improved by 23.95%, 30.95%, and 43.71%, respectively, and the PKFA improved by 8.41%, 15.92%, and 32.25%, respectively. The walking speed and PKFA in all subjects after the training showed improvement when compared with the baseline phase (p < 0.05).

Conclusions

These findings suggest that robot-assisted gait training with active motion visual feedback and guidance force may be clinically helpful to improve walking recovery after stroke.
Experimentos de elección para el manejo del Parque Nacional Los Mármoles, México
Authors: Melo-Guerrero Enrique , Hernández-Ortiz Juan , Aguilar-Lopez Antonio , Rodríguez-Laguna Rodrigo , Martínez-Damián Miguel Ángel , Valdivia-Alcalá Ramón , Razo-Zárate Ramón
Published: August 2020

Introducción: La planeación y manejo de las actividades en el Parque Nacional Los Mármoles debe incluir las opiniones de los usuarios y visitantes con la finalidad de generar alternativas económicas sustentables acordes con los objetivos de conservación. Objetivo: Estimar el valor económico por la implementación de un plan de mejoras (vías de acceso, sanidad forestal, protección a la biodiversidad y espacios para la recreación) para el manejo del Parque Nacional Los Mármoles. Materiales y métodos: El valor económico por la implementación de un plan de mejoras se estimó mediante experimentos de elección, a través del modelo logit condicional. Para ello se entrevistó a los actores clave, se hicieron talleres de diagnóstico participativo y se aplicó una encuesta a 144 turistas, quienes manifestaron el orden de las preferencias de los atributos del plan de mejora. Resultados y discusión: Los entrevistados asignaron mayor disponibilidad a pagar al atributo sanidad forestal (16.51 MXN) que a las vías de acceso y sitios de estacionamiento (13.74 MXN) y protección a la biodiversidad (9.28 MXN). El atributo sobre mejoras a los espacios para la recreación no resultó estadísticamente significativo, lo cual refleja una mayor valoración por mantener las condiciones poco alteradas del sitio. Conclusiones: Los experimentos de elección en la gestión de políticas para el manejo de las áreas naturales protegidas permitieron identificar las áreas de oportunidad y valorarlas económicamente, a través de la opinión de los actores involucrados en las actividades del Parque Nacional Los Mármoles.
Modelación de áreas susceptibles a deslizamientos de tierra utilizando SIG en bosques semiáridos y evaluación en términos de rehabilitación del bosque
Authors: Buğday Ender , Barış Özel Halil
Published: August 2020

Introducción: Para aumentar, proteger y mantener los recursos forestales, es importante determinar los factores que afectan las actividades forestales y minimizar su impacto. En este estudio se abordó el factor de deslizamientos de tierra en aplicaciones forestales. El efecto negativo de factores impredecibles de las actividades silvícolas (construcción de carreteras, cosecha, forestación, etc.) puede reducirse calculando y modelando las relaciones de susceptibilidad a deslizamientos de tierra de bosques degradados. Objetivo: Demostrar la aplicabilidad de un mapa de susceptibilidad de deslizamientos de tierra para apoyar a los tomadores de decisiones en la evaluación de bosques semiáridos, en actividades forestales y trabajos de rehabilitación. Materiales y métodos: Se introdujeron seis modelos utilizando los enfoques del sistema de inferencia difusa (FIS) y del proceso de jerarquía analítica modificada (M-AHP). Se utilizó una combinación de elevación, pendiente (grado), distancia a las fallas, litología, aspecto y curvatura del plan en los modelos. Resultados y discusión: Los modelos más exitosos bajo los enfoques FIS y M-AHP fueron el Modelo 3 del FIS y el Modelo 1 del M-AHP, con áreas bajo la curva (AUC) de 80.2 % y 78.1 %, respectivamente. El uso de la silvicultura con precisión mediante la toma de decisiones basadas en la susceptibilidad a los deslizamientos de tierra, en la etapa de gestión y planificación (por ejemplo, construcción de instalaciones de infraestructura forestal, forestación y aprovechamiento y rehabilitación de bosques), aumentará el éxito de las actividades silvícolas. Conclusión: Es muy importante determinar las áreas de deslizamiento de tierra de manera anticipada y confiable para la ejecución efectiva de prácticas silvícolas en tierras forestales susceptibles, con el fin de aumentar el éxito de las actividades silvícolas de acuerdo con el enfoque de gestión forestal sostenible.
A history of TOPMODEL
Authors: Beven Keith J. , Lamb Rob , Kirkby Mike J. , Freer Jim E.
Published: August 2020

Abstract. The theory that forms the basis of Topmodel was first outlined by Mike Kirkby some 45 years ago. This paper recalls some of the early developments; the rejection of the first journal paper; the early days of digital terrain analysis; model calibration and validation; the various criticisms of the simplifying assumptions; and the relaxation of those assumptions in the dynamic forms of Topmodel. A final section addresses the question of what might be done now in seeking a simple, parametrically parsimonious model of hillslope and small catchment processes if we were starting again.
REINFORCEMENT LEARNING HELPS SLAM: LEARNING TO BUILD MAPS
Authors: Botteghi N. , Sirmacek B. , Schulte R. , Poel M. , Brune C.
Published: August 2020

Abstract. In this research, we investigate the use of Reinforcement Learning (RL) for an effective and robust solution for exploring unknown and indoor environments and reconstructing their maps. We benefit from a Simultaneous Localization and Mapping (SLAM) algorithm for real-time robot localization and mapping. Three different reward functions are compared and tested in different environments with growing complexity. The performances of the three different RL-based path planners are assessed not only on the training environments, but also on an a priori unseen environment to test the generalization properties of the policies. The results indicate that RL-based planners trained to maximize the coverage of the map are able to consistently explore and construct the maps of different indoor environments.
PATH PLANNING FOR INDOOR CONTACT INSPECTION TASKS WITH UAVS
Authors: González-deSantos L. M. , Martínez-Sánchez J. , González-Jorge H. , Arias P.
Published: August 2020

Abstract. UAV technology has become a useful tool for the inspection of infrastructures. Structural Health Monitoring methods are already implementing these vehicles to obtain information about the condition of the structure. Several systems based on close range remote sensing and contact sensors have been developed. In both cases, in order to perform autonomous missions in hard accessible areas or with obstacles, a path planning algorithm that calculates the trajectory to be followed by the UAV to navigate these areas is mandatory. This works presents a UAV path planning algorithm developed to navigate indoors and outdoors. This algorithm does not only calculate the waypoints of the path, but the orientation of the vehicle for each location. This algorithm will support a specific UAV-based contact inspection of vertical structures. The required input data consist of a point cloud of the environment, the initial position of the UAV and the target point of the structure where the contact inspection will be performed.
RESEARCH ON SEMANTIC-ASSISTED SLAM IN COMPLEX DYNAMIC INDOOR ENVIRONMENT
Authors: Li C. , Kang Z. , Yang J. , Li F. , Wang Y.
Published: August 2020

Abstract. Visual Simultaneous Localization and Mapping (SLAM) systems have been widely investigated in response to requirements, since the traditional positioning technology, such as Global Navigation Satellite System (GNSS), cannot accomplish tasks in restricted environments. However, traditional SLAM methods which are mostly based on point feature tracking, usually fail in harsh environments. Previous works have proven that insufficient feature points caused by missing textures, feature mismatches caused by too fast camera movements, and abrupt illumination changes will eventually cause state estimation to fail. And meanwhile, pedestrians are unavoidable, which introduces fake feature associations, thus violating the strict assumption that the unknown environment is static in SLAM. In order to ensure how our system copes with the huge challenges brought by these factors in a complex indoor environment, this paper proposes a semantic-assisted Visual Inertial Odometer (VIO) system towards low-textured scenes and highly dynamic environments. The trained U-net will be used to detect moving objects. Then all feature points in the dynamic object area need to be eliminated, so as to avoid moving objects to participate in the pose solution process and improve robustness in dynamic environments. Finally, the constraints of inertial measurement unit (IMU) are added for low-textured environments. To evaluate the performance of the proposed method, experiments were conducted on the EuRoC and TUM public dataset, and the results demonstrate that the performance of our approach is robust in complex indoor environments.
ACCURACY ASSESSMENT OF DIFFERENT ERROR ADJUSTMENT METHODS IN CLOSED TRAVERSE NETWORKS; STUDYING THE IMPACT OF DIFFERENT OBSERVATION ERROR SETUPS IN DIFFERENT GEOMETRICAL CONFIGURATIONS
Authors: Amini H. , Mehrdad S.
Published: August 2020

Abstract. Similar to all infrastructural works, in order to directly prepare a map, one must act in a whole-to-part way. First, a framework containing certain coordinated points which can be used as base points for subsidiary measurements must be provided, relying on which various surveying tasks can be carried out. By means of solutions, the observation errors in determining the stable points should be propagated between all the observations. In the past, classical methods have been used due to the lack of facilities that can perform numerous calculations in a short time. In this project, we analyzed the accuracy of traditional or classical methods of error propagation in comparison with the Least Squares using simulated observational data with different accuracies. Then, with the output of different methods, the error ellipses are drawn, according to which, these outputs are compared with each other in terms of accuracy. Bowditch method resembled the results of the Least Squares in many cases while Transit method generally showed poorer accuracy and a dependence on the direction of the adjustments. Bowditch method was found to be getting closer to or even more accurate than the Lest Squares when increasing. The whole methods reached a better performance when the accuracy of angular and longitudinal observations were of the same order. Moreover, the Doubly-braced Quadrilateral and the Least Squares with constant weight were of equal accuracies, however, the accuracy of the true-weighted error propagation method outperformed the other methods.
AN INNOVATIONAL DIGITAL TOOL IN GIS PROCEDURE: MAPPING ADRIATIC COAST IN ABRUZZO REGION TO SUPPORT DESIGN OF SLOW MOBILITY ROUTES
Authors: Bianchi A. , D’Uva D. , Rolando A.
Published: August 2020

Abstract. The research work, object of this paper, is included in the "Fragile Territories" project of the Department of Architecture and Urban Studies of the Politecnico di Milano. It addresses the problem of mapping a territory, starting from the case studies of this issue in the contemporary scientific literature and trying to solve them by available raster/vector GIS database. The first innovation introduced with this research is the coding of an algorithm which takes as input the vectorized points from GIS and associates them with the heights transformed into z coordinates. The result is a three-dimensional grid of points. This grid is the basis for the creation of a single NURBS surface that will become the basis for the projection of all vector entities exported from the GIS into the modeler. In doing so, the result of the operation is a three-dimensional georeferenced NURBS model that contains all the vector entities in the territorial database.
WHEN ROMAN ANTIQUITY AND RENAISSANCE CAME TOGETHER IN VIRTUAL 3D ENVIRONMENT: 3D MODELLING CONSIDERATIONS
Authors: Koehl M. , Fuchs M. , Nivola T. , Koch J. , Cartier L. , Soussoko S.
Published: August 2020

Abstract. This paper is a review of the modelling of two edifices located in a city which developed on the vestiges of a Roman city during antiquity endowed in the 4th century with a military camp. The term castellum is used for the first structure. A second structure concerns the remains of a castle dismantled at the end of the 17th century, which was generally known only by an engraving in perspective made shortly before its demolition, and the cadastral matrix that had preserved the traces of its right-of-way. It is a Renaissance castle built in the 16th century by the Württemberg family in the northeast corner of the ruins of the castellum. The projects contain a first part of data analysis and interpretation based on available documents. Similar sites close in terms of architecture, geographical location and construction period were also visited to get inspiration from them and to be able to make proposals for restitution. Despite the lack of data available, the multidisciplinary aspect of these projects is very important. In fact, the experience of archaeologists and the monitoring of modelling throughout its progress is essential to work out models that are both justifiable, at the level of the proposals made and sufficiently complete to be able to be highlighted. Once the models validated, they are integrated in a virtual way into the contemporary urban environment, through an interactive virtual tour. This paper reviews the principles implemented during the modelling, the rendering and the valorisation of the models thru virtual tours and AR/VR implementation.
A METHOD FOR ESTIMATING THE NUMBER OF HOUSEHOLDS IN A REGION FROM THE NUMBER OF BUILDINGS ESTIMATED BY DEEP LEARNING WITH THE ADJUSTMENT OF ITS NUMBER USING ANCILLARY DATASETS: CASE STUDY IN DJAKARTA
Authors: Ito R. , Hara K. , Shimazaki Y. , Mori N. , Kani Y. , Okabe A.
Published: August 2020

Abstract. The high resolution statistical data such as the number of households in small areas are indispensable for urban planning, disaster prevention and many kinds of business activities. However, it is difficult to obtain the number of households in small areas because census data are usually aggregated in municipal districts. Techniques for automatically analyzing statistical data, e.g., land cover, population density, and the number of households obtained from satellite/aerial images have been continuously studied. In recent years, many methods using deep learning have been proposed in the related literature. In estimating the number of households, the use of buildings, the number of floors and that of rooms are also important information, but it is difficult to obtain such information from only image analysis using deep learning. This study proposes a method for estimating the number of households in 100 meter grid cells from satellite images using deep learning, and adjusting it using ancillary data obtained from a few statistical datasets. The application of this method to Djakarta shows that the difference between the estimated values and the corresponding values of census is less than 10%.