bluuebunny/crossref_metadata_2025 huggingface dataset:
C-4 analogs of podophyllotoxin as tubulin inhibitors: Synthesis, biological evaluation, and structure-activity relationship
Authors: Lu Breanna , Xu Lexi , Chen Harriet , Yu Grace , Khow Kimberly , Yang Stella , Dinker Arushi , Njoo Edward
Published: October 2023

The rich diversity of lignin small molecules derived from podophyllotoxin, a non-covalent tubulin inhibitor isolated from the Podophyllum family, has led to the discovery and clinical development of several anticancer agents including etoposide and teniposide, which received FDA approval for the treatment of various cancers through DNA topoisomerase inhibition. While these compounds share the same tetracyclic core, two subtle structural changes that differentiate 1 from its DNA topoisomerase-binding analogs—the presence of 4’ methylation on the aromatic ring and stereospecific glycosylation at the C-4 hydroxyl—yield two independent mechanisms. Given the immense pharmacological importance of these two features, we sought to establish a structure-activity relationship regarding modification at C-4 on the potency, specificity, and chemical properties of podophyllotoxin. Here, we synthesized and evaluated a systematic library of close-in diversified esters at the C-4 position of podophyllotoxin to evaluate the effect of alkyl bulk at C-4 on the potency of 4-acyl podophyllotoxin analogs as tubulin inhibitors. Additionally, we evaluate their biological target and activity through cell viability assays, tubulin polymerization assays, and cell cycle analysis. Furthermore, we rationalize our results by analyzing the interactions between each ester and the binding site of tubulin through computer docking models. Altogether, we show that increasing steric hindrance at C-4 leads to a loss in potency against human cancer cells but has an insignificant impact on the ex-vitro kinetics of tubulin inhibition. This suggests that the biological activity of our compounds may be attributed to cytosolic and membrane distribution rather than binding interactions within the colchicine site.
Hydrogen-bonded frameworks containing aliphatic 3D linkers show high-capacity water vapour sorption
Authors: Muang-Non Phonlakrit , Zhou Carmen , Macreadie Lauren , White Nicholas
Published: October 2023

Hydrogen bonded frameworks were prepared from a tetra-amidinium component and three-dimensional cubane and bicyclopentane dicarboxylate linkers. Despite the incorporation of aliphatic components, the frameworks demonstrate strong and reversible uptake of water vapour, with one of the frameworks showing water uptake at very low relative humidity.
Prediction of arithmetic abilities of children who practice sports: The use of the gamma model
Authors: Serra L. , Guerreiro C. , Silva L.
Published: October 2023

Background and Aim of Study: The physical performance that children exhibit when engaging in sports or any form of physical activity will depend not only on their physical abilities but also on their psychological and cognitive attributes. The aim of the study: to analyze whether symptoms of anxiety, lie, attention, and age are predictors of arithmetic abilities in children practicing sports. Material and Methods: The study sample consisted of 108 children with an average age of 12.12 (±2.18) who practice various sports, with greater emphasis on futsal and soccer. The study protocol consisted of a sociodemographic questionnaire, the Revised Children’s Manifest Anxiety Scale, the d2 Test of Attention, and the Arithmetic subtest of the Wechsler Intelligence Scale for Children. Results: The results showed that through the adjusted model, we identify four significant explanatory variables that are predictors of arithmetic abilities, namely anxiety symptoms (β=-0.009, p=0.009); and the attention sub-factors: processed characters (β=0.002, p=3.44e-14), default errors (β=-0.005, p=0.000), errors by marking irrelevant characters (β=-0.016, p=0.003). Conclusions: The presence of anxiety symptoms and attentional cognitive abilities play a significant role in predicting the arithmetic aptitudes of young individuals. These variables should be taken into consideration within training programs for young athletes, as they hold relevance for sports engagement.
The European Commission as Political Entrepreneur – The Europe 2020 Strategy
Authors: Silander Daniel
Published: October 2023

This study deals with the European Commission Communication Europe 2020, which was a direct result of the global economic crisis that began in 2007-2008. The focus is to explore how the Commission gained an extended role as political entrepreneur by launching the Europe 2020 Strategy and turning crisis into a window of opportunity. Europe 2020 was a Commission initiative to deal with the crisis by promoting smart, sustainable and socially inclusive development beyond the narrow scope of economic growth. The Commission addressed the economic crisis as an existential threat to European economy, but also to wealth, health integration and stability. It is argued that the crisis management of the Commission, was, in times of weakened member-state capacities, a result of political entrepreneurship.
Urban Cultural Heritage in the Digital Space
Authors: Kiniorska Iwona , Brambert Patryk , Tłuczkiewicz Urszula
Published: October 2023

The aim of the study was to identify ways of digitalising specific cultural heritage sites in the space of six selected Polish cities: Białystok, Bydgoszcz, Gdynia, Kielce, Olsztyn and Rzeszów. The data used in the analysis came from four types of online sources. Firstly, these were the official websites of the 18 sites under study, existing in the 2022. Another source of information was the tourist review portal Tripadvisor. In addition, information from popular promotional platforms and social networks was taken into account. The study used techniques applied for existing materials analysis, as well as the following methods: analytical, descriptive, internet query, statistical and graphical. An own zero-one rating system was applied, assigned to six categories of assessment of the digitalisation level of the sites. Among the analysed cities, the best results as to the level of digitalisation were obtained by the facilities located in Kielce, Rzeszów and Bydgoszcz, respectively.
Breeding and Genetics of Cultivated Plants
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Pylnev V.V.
Published: October 2023

The compilation of articles presented in this publication is a result of contributions from the conference. It covers a wide spectrum of topics within the realm of genetics, breeding, and seed production of cultivated plants. The materials included address current issues in genetics, breeding, and seed production for nearly all major crop species. This collection is designed for undergraduate and graduate students, postgraduates, educators, and researchers. It also serves as a valuable resource for anyone with an interest in the fields of plant breeding and genetics. We hope that the contents of this publication will prove beneficial and serve as inspiration for further research in this pivotal scientific domain.
The relationship between the village community and the Democratic Republican Party through election culture of the 1960s and 1970s
Authors:   The Association for Korean Modern & Contemporary History, YANG Yun-ju
Published: October 2023

This paper examines the relationship between the village community and the Democratic Republican Party in the 1960s and 1970s through farmers’ diaries in Pyeongtaek, Imsil, and Gimcheon. It's focused on the relationship between the influential people who campaign, the county and the party, and the residents who are voters. Due to the economic boom, the Republican Party overplayed its development pledges in the 1967 general elections, forcing farmers in underdeveloped regions to support the ruling party. Influential people contacted the county and the ruling party as village representatives and accordingly, construction of basic facilities. However, the opposition party did well in the 1971 general election, and the following year, Park Chung-hee carried out the October Yushin. The election culture was depressed by the new National Assembly Election Act in 1972, which reduced residents' interest in the general election. From now on the residents' concern was which candidate would spend more money, and the only campaign of influential figures was to participate in fraudulent voting. This allowed influential people to be perceived as representatives of the government or the party rather than as village leaders. While the party's campaign was retreating, residents were hoping that the community would change and develop by voting strategically rather than just following the influence.
FACTORS DRIVING DECISION MAKING FOR PURCHASING HALAL PRODUCTS IN INDONESIA: LITERATURE REVIEW
Authors: Nurfahmiyati  , Assyofa Allya Roosallyn , Nurcholisah Kania
Published: October 2023

There has been an increase in consumer demand for halal products in recent year that does not only come from Muslim consumers but also from non-Muslim consumers. They view halal products as safe and healthy. This triggers consumer awareness of halal products and is followed by the wishes of producers to fulfill their rights to halal products. This research examines factors that drive purchasing decisions for halal products in Indonesia through a literature review. The findings of this research show there are several factors that determine someone’s decision to purchase halal products, i.e., religiosity, halal label, halal lifestyle, product knowledge, and Islamic branding/advertising.
Keywords: Halal, Halal products, Indonesia, Purchase decision.
Effects of Amino Acids on Food Intake, Silk Gland and Protein Content of Silkworm, Bombyx mori L
Authors:   Department of Sericulture, Forest College and Research Institute, Tamil Nadu Agricultural University, Mettupalayam – 641 301, India., kA MURUGESH , R ARUNA ,   Department of Sericulture, Forest College and Research Institute, Tamil Nadu Agricultural University, Mettupalayam – 641 301, India.
Published: October 2023

Studies were undertaken to assess the effects of amino acids on the food intake, silk gland, and protein content of silkworm, Bombyx mori L. Three amino acids, namely Glycine, Alanine and Serine at various concentrations viz., 10, 20, 50, 100 and 200 ppm were used for the investigations. The silkworm larvae were supplemented with amino acids, once daily in the morning from first day of fifth instar to spinning. Experimental results showed that irrespective of the concentrations studied, the amino acids had positive influence on the food intake, silk gland, and protein content of silkworms. Though all the treatments were found to significantly increase different parameters namely co-efficient of food utilization, weight and length of silk gland, protein content in silk gland, haemolymph and cocoon the enhancement was highest at concentration of 10 ppm, 100 ppm and 100 ppm, respectively in Glycine, Alanine and Serine
Price Patterns in Agricultural Futures Markets: A GARCH Model Approach
Authors:   1Tamil Nadu Agricultural University (TNAU), Coimbatore – 641003, India., D Kalaiarasi , A Rohini ,   1Tamil Nadu Agricultural University (TNAU), Coimbatore – 641003, India., N Venkatesa Palanichamy ,   1Tamil Nadu Agricultural University (TNAU), Coimbatore – 641003, India., KM Shivakumar ,   1Tamil Nadu Agricultural University (TNAU), Coimbatore – 641003, India., R Pangayar Selvi ,   1Tamil Nadu Agricultural University (TNAU), Coimbatore – 641003, India., K Chandra Sekhar ,   Centre for Economic and Social Studies (CESS), Hyderabad - 500016, India.
Published: October 2023

The outbreak of corona virus has affected the financial market internationally in an unprecedented way. Due to the devastations that emerged in the international market, the Indian financial market proportionally reacted to the pandemic and further witnessed violent volatility. Considering the COVID-19 situation, this paper is an empirical investigation on the impact of COVID-19 on agricultural commodities, specifically on NCDEX platform. Using daily closing future prices of guar seed, jeera, turmeric, and Coriander on NCDEX, this study examines the impact of COVID-19 on the selected commodities over the period from 24th December 2019 to 24th June 2020, representing three months before and during the covid – 19 spread. This study has tried to compare the future prices in the pre-COVID-19 period and during the COVID-19 situation, by using GARCH Model. Findings reveal that the price of jeera, turmeric and coriander has encountered instability during the Corona pandemic period.
AGRONOMIC VIEW OF SOIL SALINITY, ITS EFFECTS AND RECLAMATION - A Review
Authors:   1Ph.D. Scholar, Department of Agronomy, Tamil Nadu Agricultural University, Coimbatore-641003, Indi, S Kaviyazhagan , K Prakash ,   2Ph.D. Scholar, Department of Agricultural Entomology, Tamil Nadu Agricultural University, Coimbatore-641003, India
Published: October 2023

Abiotic stress, particularly soil salinity, is currently to blame for a decline in the quality of world crop production and significant losses to global agricultural output. Plants are faced with enormous difficulties as a result of this stress, which has a detrimental effect on their productivity, growth, and development. In recent years, the amount of cultivated land with salinity and alkalinity issues has expanded. Agro-techniques for reclamations of saline soils such as leaching, drainage, using soil amendments, suitable choice of crops and varieties, etc. have been standardised over the years for its management due to the need to increase agricultural productivity as the global population grows exponentially. To improve crop output, it is necessary to increase agro techniques for managing and reducing soil salinity. The mechanism, traits, impacts, and reclamation of soil salinity for improved crop growth and development will all be covered in this paper
Awareness and Consumption of Millet Products Among College Students in YSR (Kadapa) District, Andhra Pradesh
Authors:   *Department of Agricultural and Rural Management, Tamil Nadu Agricultural University, Coimbatore-641 003, India, Kumar Gomanth , S D Sivakumar ,   *Department of Agricultural and Rural Management, Tamil Nadu Agricultural University, Coimbatore-641 003, India, M Chandrakumar ,   *Department of Agricultural and Rural Management, Tamil Nadu Agricultural University, Coimbatore-641 003, India, M Shanthasheela ,   Department of Agricultural Extension, Tamil Nadu Agricultural University, Coimbatore - 641 003, India, V Anandhi ,   Department of Physical Science and Information Technology, Tamil Nadu Agricultur al University, Coimbatore-641 003, India
Published: October 2023

The millets or "Nutri-cereals" or superfoods, are highly nutritious and offer various health benefits. Despite their advantages, millet production has declined in India from 2010-11 to 2020-21 at -0.94 Compound Annual Growth Rate (CAGR). This study focuses on assessing the awareness, analyzing the consumption pattern and the factors influencing the consumption of millet products among college students in the YSR (Kadapa) district, Andhra Pradesh. The primary data for the study was gathered through structured interviews with 120 college students from four colleges in the study area. The respondents' demographic, economic, social, psychographic, and behavioral features were analyzed. The study revealed that most respondents (94.17 per cent) were aware of millet based products, and 80.83 per cent respondents were aware through word of mouth from family and friends. Products made with Ragi millet were the most consumed millet products. The health and nutritional benefits was the key factor influencing millet product consumption. The findings can assist businesses in effectively marketing their millet-based products.
ANÁLISE DE MOBILIDADE INTERGERACIONAL NO BRASIL: PERSPECTIVAS A PARTIR DAS RENDAS DOS PAIS E MÃES
Authors: Andrade Filipe , Cruz Mércia Santos da
Published: October 2023

Aiyar e Ebeke (2020) estabelece que a relação entre desigualdade de renda e crescimento é influenciada pelo nível de igualdade de oportunidades, que pode ser medido pelo grau de mobilidade intergeracional de renda. O trabalho aqui realizado tem por finalidade estimar essa
mobilidade para a sociedade brasileira, considerando tanto a renda dos pais quanto das mães, com dados da PNAD de 1989 e 2014. Os principais resultados encontrados indicam um grau de mobilidade de 0,56 (entre filho e pai), 0,60 (entre filha e pai), 0,48 (entre filho e mãe) e 0,27 (entre filha e mãe). Isso representa uma mobilidade menor do que a de países desenvolvidos, porém maior que a de países da América Latina.
Discurso Literário e Cinematográfico: Estratégias de Leitura e Interpretação no Ensino Médio
Authors: Silva Antoniel Guimarães Tavares , Pereira Anísio Batista
Published: October 2023

O ensino de língua materna no Ensino Médio passou, na atualidade do ano de 2022, por dois fatores relevantes: a ampliação do uso das tecnologias na Educação e o retorno das aulas presenciais, pausadas durante o período da quarentena, como medida de prevenção de contágio do vírus SARS-CoV-2 (Covid-19), que acarretou no uso de mídias digitais como ferramenta de ensino e aprendizagem no período de dois anos letivos. Assim, torna-se necessário alinhar as estratégias pedagógicas adotadas pelos docentes, a fim de abarcar as transformações no modo como se aborda a leitura e interpretação de obras literárias. Nesse contexto, objetivamos refletir e propor ferramentas de leitura e interpretação a partir da análise discursiva de obras literárias em relação às suas adaptações fílmicas, para se pensar sobre as condições sociais, históricas e culturais de emergência de enunciados regulares nas produções cinematográficas contemporâneas enquanto releitura de textos clássicos. Para tanto, valemo-nos do campo teórico da Análise do Discurso Foucaultiana. Dessa forma, propomos articular metodologias para a leitura e interpretação orientadas pelos professores tanto das obras clássicas quanto das adaptações cinematográficas que, consequentemente, viabilizam medidas de intervenção no planejamento de aulas repensadas e redirecionadas para o contexto da atualidade.

Palavras-chave: Literatura, Cinema, Leitura, Interpretação.
MAPEAMENTO DE ÁREAS SUSCETÍVEIS A MOVIMENTOS GRAVITACIONAIS DE MASSA E INUNDAÇÕES NA REGIÃO DA MACROMETRÓPOLE PAULISTA
Authors: BITAR OMAR YAZBEK , CAMPOS SOFIA JÚLIA ALVES MACEDO , MONTEIRO ANA CÂNDIDA MELO CAVANI , ARGENTIN PRISCILLA MOREIRA , CORSI ALESSANDRA CRISTINA , PAULON NIVALDO
Published: October 2023

Este artigo sintetiza os resultados finais dos trabalhos
de mapeamento de áreas suscetíveis a movimentos
gravitacionais de massa e inundações efetuados na região da Macrometrópole Paulista, que compreende 174
municípios do Estado de São Paulo. Os trabalhos de
mapeamento foram realizados entre 2013 e 2020, por
meio de parceria entre o Serviço Geológico do Brasil
e o Instituto de Pesquisas Tecnológicas do Estado de
São Paulo, em vista da implantação da Política Nacional de Proteção e Defesa Civil e da execução do Plano
Nacional de Gestão de Riscos e Resposta a Desastres
Naturais, bem como do Programa Estadual de Prevenção de Desastres Naturais e de Redução de Riscos do
Estado de São Paulo. O objetivo geral do mapeamento
realizado é o de elaborar o zoneamento cartográfico
das distintas suscetibilidades a processos geológicos e
hidrológicos que ocorrem na Macrometrópole Paulista. Os métodos empregados na elaboração das cartas
de suscetibilidade geradas consideraram os principais processos do meio físico incidentes na região, analisados a partir da compilação, tratamento e integração
de dados geológicos, geomorfológicos, hidrológicos
e outros materiais previamente disponíveis ou obtidos durante os trabalhos, utilizando-se modelagens computacionais e verificação de campo. Os resultados obtidos compreendem a classificação do território de cada município da região em zonas de alta, média e
baixa suscetibilidade, segundo dois conjuntos básicos
de processos: deslizamento, rastejo e queda de bloco; e
inundação e/ou alagamento. Apontam-se também as
bacias de drenagem suscetíveis à geração de corrida de
massa e enxurrada. A carta síntese de suscetibilidade
elaborada contém, ainda, feições correlatas aos processos mapeados, bem como indicadores que propiciam
estimar a incidência em área referente a cada classe no
município. Ao final, apresentam-se conclusões sobre os
trabalhos realizados e recomendações gerais para utilização das cartas de suscetibilidade produzidas, tanto
por parte das administrações municipais quanto no
planejamento regional.
CONGLOMERADO FERRUGINOSO LATERÍTICO (LATERITA) DA ILHA DE SÃO LUÍS DO MARANHÃO: UMA DISCUSSÃO DO POTENCIAL PARA USO EM CONCRETO DE CIMENTO PORTLAND
Authors: OLIVEIRA JOSÉ EDWARD DE , ROTUNNO FILHO OTTO CORRÊA
Published: October 2023

O estudo versa sobre as características de um determinado tipo de laterita, denominado conglomerado
ferruginoso laterítico (agregado pétreo), do ponto de
vista químico, físico, mecânico e geológico. Nesse estudo foram executados, ao final, ensaios em corpos de
prova em concreto de cimento Portland aproveitando
a laterita de melhor qualidade existente em São Luís
no estado do Maranhão, com objetivo de se obter a
resistência máxima atingida usando esse tipo de agregado. Justifica-se como sendo de melhor qualidade, o
conglomerado ferruginoso laterítico pelo fato dessa
rocha apresentar quando britada uma curva granulométrica mais perfeita, quando comparada a curva
teórica de “Füller”. Ao estudo foi dado ênfase em primeiro plano as características do material, com base na
geologia de engenharia, que o fez destacar de outros
estudos, pelo fato de ter sido utilizado a rocha laterítica (agregado), tal como saiu do britador com mandíbulas reguladas com aberturas de 50,8 mm, ou 2”,
38,1 mm, ou 1½” e ainda 25,4 mm ou 1”, fornecendo
nesta britagem, tanto os agregados graúdos como os
agregados finos, quando britado, conforme pode ser
verificado nas curvas granulométricas apresentadas na
figura 10. O conglomerado ferruginoso laterítico (agregado), depois de britado, revelou a forte influência do
grau de alteração da rocha no comportamento da granulometria após britagem, o que permitiu corrigir a
curva granulométrica com frações granulométricas da
mesma rocha, para obtenção de resistência máxima à compressão axial simples, testada no corpo de prova
do concreto, devido a uma melhor arranjo geométrico
das partículas e consequente menor índice de vazios
no corpo de prova do concreto, atingindo valores de
resistência a ruptura entre 31,1 a 34,2 MPa, com duas
variáveis de traço 1:4 - 1:6 e a fator (a/c) água cimento
0,45 - 0,50 respectivamente. Essa rocha/agregado atingiu resistência individual a ruptura entre 29,1 a 42,3
MPa revelando a grande heterogeneidade da rocha. A
composição química da rocha realizada através da via
úmida e fluorescência são coerentes apresentando valores de SiO2 variando de 8,0 a 8,8 e Fe2 O3 variando de
75,6 a 75,6%, tabelas 1 e 2.
Myosteatosis and Frailty Factors associated with the occurrence of Complications in Cirrhotic patients: MYOFACC study
Authors: Bernard El Khoury , S Khazaka , N Chalhoub , F Abi Habib , L Saba , Y Sarkis , K Honein , R Sayegh , R Slim , C Yaghi
Published: October 2023

Background and aim: Cirrhosis leads to sarcopenia and to life-threatening complications in decompensated stages. The objective of this study is to show the impact of the loss of muscle mass and function on hepatic decompensations. Methods: Our study compares a group of cirrhotic patients with controls matched with the same sex and age. A questionnaire was created to collect demographic, anthropometric, and cirrhosis characteristics. Several CT scan sections were analyzed and the average measurements have been grouped into tertiles to estimate the impact on cirrhotic complications. Results: Our study included 33 controls and 33 cirrhotic patients of which 59.4% had NASH. Anthropometric characteristics were similar in cirrhotics men and women. Grip strength was significantly lower in cirrhotic men. Using the skeletal muscle index we found 39.39% of cirrhotic patients were sarcopenic mostly men 84.61%. In Cirrhotic men, the density of the psoas and paravertebral muscles was lower than in controls. In women psoas and paravertebral muscle areas were comparable and the total muscle surface in cirrhotic patients was higher. There was a negative correlation between this surface and the density of the psoas (r = -0.293 p = 0.017) indicating the presence of myosteatosis in women. Analysing tertile groups showed a significantly higher incidence of complications related to liver disease and liver failure in patients with the psoas and paravertebral muscle density in the lowest tertile and in the frail population according to the frailty index. Conclusion: Cirrhotic patients have myosteatosis and sarcopenia associated with a higher incidence of complications related to hepatic failure.
Preventing Coronary Occlusion in an Elderly Severe Aortic Stenosis Patient with Critically Low Coronary Heights – A Case Report
Authors: Viveka Kumar
Published: October 2023

Background: Transcatheter Aortic Valve Replacement (TAVR) is an established treatment for severe, symptomatic Aortic Stenosis (AS). However, the presence of low coronary heights confers a high risk for coronary obstruction during or after TAVR. Case: In this case report, we present our experience with transfemoral-TAVR in an elderly, high-risk (STS score – 12.08%) female severe AS patient with low coronary heights (right: 7.4 mm, left: 8.7 mm). She had lower annulus area (287 mm2) and moderately low valve area (0.7 cm2) as well. Her mean and peak pressure gradients (PGs) were 38 mmHg and 61 mmHg, respectively. Upon the Heart Team’s evaluation, TAVR was recommended and a 20 mm Balloon Expandable (BE) Myval Transcatheter Heart Valve (THV) was selected. No peri-procedural or post-procedural complications were reported and the post-procedural hemodynamics, namely the mean and peak PGs improved to 16 mmHg and 30 mmHg after TAVR, respectively. The patient was discharged in a stable condition after four days of hospital stay. Conclusion: We report the successful implantation of a small-sized BE Myval THV (20 mm) in a patient with low coronary heights. Life-threatening complications including paravalvular leak, coronary obstruction, or annular rupture were well averted; hence, we ascertain that the Myval THV is a suitable device for treating severe AS in difficult anatomies. However, the viability of the novel valve needs to be reaffirmed in larger studies.
Investigation of Malpractice Claims Concerning Orthopedic Surgeons in Sari, North of Iran, 2015-2020
Authors: Amin Darroudi , Ali Abbasi , Masoud Shayestehazar
Published: October 2023

Introduction: Treatment failure and claims against physicians may have many negative consequences. Orthopedic surgeons have always been among the most used specialists. Therefore, the investigation of causes and the process of these claims can help reduce the negative effects of medical malpractice on physicians and society. Materials and methods: This retrospective study investigated all medical orthopedic negligence cases in Sari, Iran, from March 2015 to March 2020. Data were collected using a researcher-made checklist and analyzed in SPSS software (V-21). Results: Out of 57 finalized cases investigated in this study, surgeons were found liable in 23 (40%) cases. The mean ± SD age of patients was 41 ± 19.3. Moreover, the level of education had a positive correlation with the surgeon’s liability. The most common cause of complaint was reduced Range of motion (ROM) and the most common type of complained surgery was “open reduction & internal fixation” (ORIF). None of the surgeons were found liable due to surgical site infection or device failure. The mean ± SD time for the file processing was 11.1 ± 10.1 months. The mean indemnity payment was 320 million Iranian Rials (9.7% of indemnity for death in Iran). Conclusion: The most effective way to reduce medical complaint cases is to increase the knowledge and skill levels of physicians. The lack of a blinded arbitration system in both organizations could lead to bias in the case assessment process. Moreover, considering the long processing time of the claims, it is recommended that new technologies should be used to reduce the time and increase the accuracy of the final verdict. The absence of a ‘no-fault’ compensation program is a significant flaw in Iran violating patients’ rights. Also, more studies are needed to evaluate justice and equality in Iranian medical commissions.
Oficinas pedagógicas
Authors: Santos Rosane Barreto Ramos , Queiroz Paulo Pires de
Published: October 2023

O trabalho traz um recorte da pesquisa de doutoramento em saúde mental e educação. O objetivo geral deste estudo consiste em investigar alternativas político-pedagógicas que possam contribuir para o bem-estar dos professores da Fundação de Apoio à Escola Técnica (FAETEC). Como objetivo específico, busca-se identificar as demandas e os casos de adoecimento psicológico entre os professores da Fundação no período de 2017 a 2021. Com base na metodologia de pesquisa qualitativa, presente no método da pesquisa-ação, utilizou-se a análise de conteúdo para o tratamento dos dados levantados. Os resultados indicam a ausência de uma abordagem sensível em relação à saúde mental dos profissionais da educação, bem como a escassez de ambientes de trabalho que promovam um acolhimento adequado para que as práticas dialógicas se tornem uma parte integrante da rotina docente. Além disso, os resultados enfatizam a importância de implementar políticas institucionais que abordem a saúde mental dos professores como um tópico de destaque nas agendas das escolas.
The pharmacist’s attitudes and knowledge of pharmacogenomics and the factors that may predict future engagement
Authors: Donthu VenkataTeja  , Yerikala Ramesh  , Penabaka Venugopalaiah  , Y Prapurna Chandra
Published: October 2023

The aim of the study is to describe the Pharmacist’s attitudes and knowledge of pharmacogenomics and the factors that may predict future engagement. The primary objective of this survey was to determine how post-graduate education and training influences pharmacist’s knowledge and attitudes of pharmacogenomic testing. In summary, pharmacists with more post-graduate education and training responded more favorably to taking on pharmacogenomic testing. In order to best implement wide-spread testing, pharmacists with post-graduate training could be utilized first as a basis of knowledge for adoption of pharmacogenomics programs. Increased visibility and usage of educational resources will be needed for the majority of pharmacists to have a baseline knowledge of pharmacogenomic testing.
Kalanchoe pinnata aqueous extract efficacy against myocardial infarction and effects on three cardio-metabolic biomarkers in NaCl-overloaded rat
Authors: Orelien Sylvain Mtopi Bopda  , Pascal Monju Mbigah  , Esther Ngo-Lemba Tom  , Anne Laupy Awah  , Benjamin Koko  , Théophile Dimo
Published: October 2023

Cardiovascular diseases are among the causes of global mortality in the world with hypertension and myocardial infarction being one of the key risk factors. Kalanchoe pinnata is a plant that has shown antihypertensive and cardioprotective effects in rat model. This research aimed at investigating the cardioprotective effect of Kalanchoe pinnata on concurrent NaCl overloading and myocardial infarction condition in rats. Thirty animals both males and females were divided into 5 groups of 6 animals each, a normal/neutral control, negative control group, positive control group and two groups that received two doses of the leaf aqueous extract (100 mg/kg and 150 mg/kg). Hypertension was induced by excess salt loading (18%NaCl) meanwhile myocardial infarction was induced by subcutaneous injection of isoproterenol (100 mg/kg). Levels of total cholesterol, triglyceride, low density lipoprotein and cardiac troponin were determined using commercial kits. Administration of excess NaCl concurrently with isoproterenol caused a significant 82% elevation in triglyceride levels. Both doses of the extract reduced non-significantly the level of triglycerides, total cholesterol and low density lipoprotein. Meanwhile the level of troponin was also significantly elevated (P<0.001) in the negative control group (2.49±0.21 ng/dL) compared to the normal (0.49±0.04 ng/dL). Cardiac troponin level was significantly reduced (P<0.05) by 52% in the extract treated groups compared to the negative control. Examination of heart tissues revealed damages in the negative control group meanwhile positive control and groups that received the extract showed no damage. Therefore, Kalanchoe pinnata is efficacious in preventing myocardial infarction even in salt loaded rats.
PENGENALAN PROBIOTIK SEDERHANA UNTUK TERNAK AYAM KAMUPUNG DI DESA PERSIAPAN URSANA KECAMATAN INAMOSOL KABUPATEN SERAM BAGIAN BARAT
Authors: Horhoruw Wiesje Martha , Ririmasse Pieter Melianus
Published: October 2023

Ursana Village is one of the preparatory hamlets for division into a village in Inamosol District. The most commonly kept livestock are cattle and native chickens. Constraints from the development of this farm, namely the lack of readiness, knowledge and skills of breeders. The potential development of free-range chicken has not been maximized. This is due to the lack of knowledge and motivation of the community in handling chicken diseases. Chicken disease is one of the risks that needs to be watched out for and faced with its own challenges in farming activities. Probiotics can increase livestock production when given regularly. The purpose of PKM is the application of probiotics to native chickens in disease prevention. This activity includes a social approach with the village government to take inventory of free-range chicken breeders for counseling, distribution of brochures to breeders or counseling participants, and demonstrations of making probiotics. Community service activities carried out in the Ursana Preparation Village increased the knowledge and skills of farmers regarding disease recognition and the manufacture of simple probiotics
Smart City Masterplan Policy Innovation In Public Service Development In The City Of Padang Panjang
Authors: Sukmawati Nur , Armida Sari Jayanti
Published: October 2023

Smart City is a city management that utilizes various resources effectively and efficiently to solve various city problems using innovative, integrated and sustainable solutions to provide infrastructure and provide city services that can improve the quality of life of its citizens. The digital transformation process carried out in the City of Padang Panjang and all efforts to increase digitization and increase digital literacy. Based on the relatively fast population, it can cause various problems typical of urban areas, such as a decrease in the quality of public services, reduced availability of residential land, congestion on the highway, difficulty in getting a parking space, accumulation of garbage, and other social problems. In this study the approach used is a qualitative approach, used to examine the condition of natural objects, where the researcher is the key instrument, the data collection technique is done by triangulation (combined). After doing the research, it can be seen that the purpose of the smart city program in the city of Padang Panjang is where the community can participate in helping the management of existing resources and participate in providing the right information to the local community. The goal is to provide innovative solutions in handling and solving major problems, providing convenience, security and comfort for the community, improving the quality of life of the people of Padang Panjang City to a better level.
Comparing pedagogical competence performances of English and non-English educational background teachers in teaching English at an elementary school
Authors: Dewi Isna Rafika , Haryanti Rahayu Puji , Faridi Abdurrachman
Published: October 2023

Regulation of the Minister of National Education number 16 of 2007 stated that Teachers at the Elementary school level (SD/MI), or other equivalent forms, must have a minimum educational academic qualification of diploma four (D-IV) or bachelor (S1) in the field of Primary Education (D-IV/S1 PGSD/PGMI) or psychology obtained from an accredited study program. Thus, there are many schools that have English teachers from non-English educational backgrounds (NEB) rather than English teachers from English educational backgrounds (EEB). This condition will affect the quality of English teaching in Elementary schools. In order to evaluate further the suitability of government regulation regarding teachers’ criteria in teaching Elementary students, this study was to compare the pedagogical competence of English and non-English educational background teachers in teaching English at the elementary school level. The design of the study is qualitative research with a case study approach. The researcher took four English teachers consisting of two English teachers with EEB and two English teachers with NEB. This study used interviews, observation, and questionnaires to collect the data. This study used 10 indicators from the Ministry of Education, 2007. The results showed that from the 10 aspects, it can be highlighted that English teachers from EEB and English teachers from NEB have similarities and differences in implementing the indicators of pedagogical competence established by the Ministry of Education, 2007. It showed that the English teachers from EEB are more dominant in implementing indicators 1,2,8,9,10. Furthermore, the English teachers from NEB are more dominant in indicators 6 and 7. Thus, they have similarities in the rest of the indicators (3,4,5).
The articulation of anti-Asian sentiment in America: frames in BTS’ tweet and press release
Authors: Maru Mister Gidion , Kinanti Dewi , Andries Fivy A , Kimbal Rahel W
Published: October 2023

Despite the Covid-19 pandemic has been considered being over, yet it remains to leave global traces of reaction including in America. This study aims at investigating Anti-Asian Sentiments in Bangtan Sonyeondan (BTS)’ Tweet and Press Release. Basing upon the curiosity of how the that particular sentiment spread in America and the reaction toward it from the perspective of the Asian. This study applies a qualitative method relying upon the data taken from an officially transcribed texts of short press the release video by Bangtan Sonyeondan (BTS)’ in YouTube as display in the White House website and Bangtan Sonyeondan (BTS)’ tweets posted to support Stop Asian Hate Movement. The analysis employs Huckin's Critical Discourse Analysis theory The results show that sentiment frames emerge in the forms of the violent attacks, discrimination, and the degradation of self-esteem. The existence of such sentiments has encouraged some reactions namely the awareness of Asian identity, the awareness of the rise of hate crimes, and the awareness of of supporting Stop Asian Hate movement. These findings implies that the BTS expressions language can act as an instrument of advocacy, power of negotiation, and expression of ideology. Thus, this study is significant for further studies on text analysis and rhetoric expressions, and cultural studies in general.
Root coverage using modified tunneling technique with acellular dermal matrix for treatment of gingival recession associated with orthodontic treatment: A case report
Authors: Pratiwi Rosa , Ratnawati Irma Dewi , Krismariono Agung
Published: October 2023

Background: Gingival recession has a number of causes, including orthodontic therapy. The degree and extent of gingival recession and orthodontic therapy are strongly correlated. Care must be taken in choosing the best soft tissue grafting technique. Development of a number of new and improved surgical techniques, including the modified tunneling technique. Case Management: A-24-year-old female patient came to Periodontic Clinic Dental Hospital of Airlangga University with a chief complain of gingival recession in mandibular central incisors since 6 months ago. The patient complained about dental sensitivity. The dental history revealed that she had undergone fixed orthodontic therapy for 7 years. She revealed the fixed orthodontic appliance was put off since 8 months ago. The patient concern about her appearance and aesthetic problem. Gingival recession on buccal surface tooth 31 and 41 extending 1,5-2 mm apical of the incisors was found in clinical assessment. This case classified as Miller class III. The doctor planned root coverage procedure using modified tunnel technique. Acellular dermal matrix (Surederm®) was chosen as a gingival graft. Discussion: Creating a "tunnel" through the buccal mucosa to treat gingival recession enables coronal repositioning of the soft tissue with predictable root coverage and a pleasing appearance. Tissue graft implantation is made possible by a horizontal incision. Conclusion: In brief, root coverage using modified tunnel technique is effective and predictable treatment modality. Comparing with other root coverage method it give quite satisfying result. The use of Acellular Dermal Matrix (ADM) considered as an alternative to Connective Tissue Graft (CTG).
Alfa Mangostin Extract (Garcinia Mangostana L) Effectiveness on the Biofilm Thickness Growth of Streptococcus Sanguinis.
Authors: Praptiningsih Rahmawati Sri , Pratiwi Rosa , Nurafifah Tazkia Yustisiani
Published: October 2023

Background: Periodontal disease is caused by the accumulation of bacteria from biofilms in the periodontal tissues. Streptococcus sanguinis is one of bacteria lives in biofilm. One of the herbal ingredients that can be used as an antibacterial is the mangosteen fruit (Garcinia mangostana L.), especially the rind of the mangosteen fruit. The main compound in the mangosteen rind is known as alfa-mangostin, the compound alfa-mangostin has anti-bacterial benefits. The purpose of this research is to determine the effectiveness usage of alpha mangostin toward Streptococcus sanguinis biofilm thickness growth.
Method: Experimental research design, with post-test only control group design with a sample size of 27. The treatment group consisted of alpha mangostin 3.125, 6.25, and 12.5 g/ml and the control group were distilled water. Measurement of Streptococcus sanguinis biofilm thickness was carried out by ELISA-reader. The statistical test was carried out using the One Way Anova test.
Results: The results showed the lowest average thickness of Streptococcus sanguinis with the addition of -mangostin 12.5 g/ml was 0.371, while the thickness of Streptococcus sanguinis with the addition of chlorhexidine was the highest at 1.860. One Way Anova test obtained a significance number of 0.001 (p
Clinical Identification of Tongue Cancer: A Case Report Series
Authors: Mujayanto Rochman , Alaydrus Fatimah , Cakra Ardiyan
Published: October 2023

Background: Dentists play an important role in oral cancer case finding. Dentists in the first line of healthcare can make identification through history taking and clinical examination.
Case(s): The first case; a 40-year-old female complained of tongue ulcers sinces 2 months. The patient had articulation changes and clinical examination results of T2 N2a. The second case; 43-year-old male complained of tongue ulcers sinces 5 months. The patient had articulation changes and the clinical examination result was T2 N2a. The third case; 65-year-old male complained of tongue ulcers sinces 2 years. The patient had changes in articulation and clinical examination results T2 N2a. All patients were referred to an oncological surgeon.
Conclusion: The change in the patient's voice, the discovery of extraoral lymphadenopathy (N), and the description of intraoral lesions (T), formed the basis of the patient's referral to an oncological surgeon.
Analysis of the Morphology of the Gastroduodenal Zone Mucous Membrane in Chronic Pancreatitis in Comorbidity with Chronic Viral Hepatitis C Under the Influence of Combined Hepatoprotection
Authors: Khomyn Halyna , Babinets Liliia , Halabitska Iryna
Published: October 2023

Recently, in medicine, the influence of infectious, hepatobiliary, gastric and duodenogenic factors for the formation and course of chronic pancreatitis (CP) and chronic hepatitis C virus (CHCV) which was treated etiotropically is increasingly being studied. Hepatitis C virus (HCV) is an important infectious factor in CP, for which the ability to chronic course has been proven. The condition of the mucous membrane of the organs in the gastroduodenal zone (GDZ) in the combined course of CP and HCV is important for the patient’s quality of life, as well as for assessing the safety of the performed and planned restorative complex treatment of such patients.
The objective: to analyze the dynamics of morphological changes of the mucous membrane in the gastrointestinal tract of patients with CP in comorbidity with etiotropically treated HCV under the influence of a protocol therapeutic complex with the additional inclusion of hepatotrophic drugs.
Materials and methods. We analyzed the data of 55 patients with CP in comorbidity with HCV after etiotropic treatment of HCV, who were examined according to generally accepted algorithms and received a generally accepted complex of treatment according to the CP protocol.
The patients were divided into two groups: the 1st group – 20 patients who received a generally accepted complex of treatment according to the protocol (PC) for 3 months; the 2nd group – 35 patients who received treatment according to the PC with the additional inclusion of a hepatotrophic agent for 3 months. In all the patients before and after treatment a morphological study of biopsies of the mucous membrane of the stomach and duodenum was performed.
Results. In the course of the study, a significant improvement in the mucous membrane morphology of the GDZ of patients with a combination of CP and HCV was established after a course of treatment with the use of hepatoprotectors, namely: a decrease in lymphohistiocytic infiltration – by 3.97 times, restoration of the gland structure that did not undergo complete non-metaplastic atrophy – by 5,13 times, increased proliferation of the glandular epithelium as a sign of morphological restoration of the epithelium – 3.9 times, decrease in signs of epithelial dysplasia – 10.35 times, decrease in the number of erosions of the mucous membrane of the organs of the gastrointestinal tract – 2.6 times.
Conclusions. The higher efficiency and safety of the complex treatment with the additional inclusion of a combination of hepatotrophic agents on the morphological condition of the mucous membrane of the organs of the gastroduodenal zone have been substantiated.