bluuebunny/crossref_metadata_2025 huggingface dataset:
Reappearance of a Mistake. (On the history of a disappeard text by N.A. Nekrasov)
Authors: Feduta Alexander I.
Published: February 2021

In posthumous editions of K.I. Chukovsky’s works, including the newest 15-volume Collected Works, his article “The Poet and the Executioner” (1922), which is essentially devoted to the poem “Raising the Grace Cup...” addressed to M.N. Muravyov-Vilensky, is re-published. In the 1930s B.Ya. Bukhshtab finally disavowed the authorship of N.A. Nekrasov, and Chukovsky not only excluded this poem from the body of the poet's works, but also refused to republish his article. Now its republishing requires detailed reservations and explanations, which can be facilitated by the reconstruction of scientific polemics of the past decades. Thу article is devoted to its history.
Hydrodynamics of a Fast and Highly Exothermic Liquid-Liquid Oxidation Process with in-situ Gas Production in Microreacto
Authors: Liu Saier , Li Guangxiao , Shang Minjing , Wei Huilong , Luo Zheng-Hong , Su Yuanhai
Published: February 2021

Hydrodynamics characteristics of a fast and highly exothermic
liquid-liquid oxidation process with in-situ gas production in
microreactors was studied using a newly developed experimental method.
In the adipic acid synthesis through the K/A oil oxidation with nitric
acid, bubble generation modes were divided into four categories. The gas
production became more intensive and unstable, even explosive with
increasing the oil phase feed rate and the temperature. A novel
automatic image processing method was established to monitor the
instantaneous fluid velocity online by tracking the gas-liquid
interface. The axial fluid velocity at the same location was unstable
with obvious fluctuation due to the unstable gas production rate.
Furthermore, the actual average residence time was obtained easily with
being only 36% of the space-time minimally, beneficial for establishing
accurate kinetic and mass transfer models with time participation.
Finally, an empirical correlation was developed to predict the actual
residence time under different conditions.
Discerning a Smile -- The Intricacies of Analysis of Post-Neck dissection Asymmetr
Authors: Thomas Rachael , Whittaker Joshua , Pollock Jonathan
Published: February 2021

Introduction Iatrogenic facial nerve palsy is distressing to the patient
and clinician. The deformity is aesthetically displeasing, and can be
functionality problematic for oral competence, dental lip trauma and
speech. Furthermore such injuries have litigation implications. Marginal
mandibular nerve (MMN) palsy causes an obvious asymmetrical smile. MMN
is at particular risk during procedures such as rhytidoplasties,
mandibular fracture, tumour resection and neck dissections. Cited causes
for the high incidence are large anatomical variations, unreliable
landmarks, an exposed course and tumour grade or nodal involvement
dictating requisite nerve sacrifice. An alternative cause for
post-operative asymmetry is damage to the cervical branch of the facial
nerve or platysmal dysfunction. This tends to have a transient course
and recovers. Distinction between MMN palsy and palsy of the cervical
branch of the facial nerve should therefore be made. In 1979 Ellenbogen
differentiated between MMN palsy and “Pseudo-paralysis of the
mandibular branch of the facial nerve”. Despite this, there is paucity
in the literature & confusion amongst clinicians in distinguishing
between these palsies, and there is little regarding these
post-operative sequelae and neck dissections. Method This article
reflects on the surgical anatomy of the MMN and cervical nerve in
relation to danger zones during lymphadenectomy. The authors review the
anatomy of the smile. Finally, we utilise case studies to evaluate the
differences between MMN palsy and its pseudo-palsy to allow clinical
differentiation. Conclusion Here we present a simple method for clinical
differentiation between these two prognostically different injuries,
allowing appropriate reassurance, therapy & management.
What Are The Factors That Affect Post COVID 1st Month's Continuing Symptoms?
Authors: Ozyurek Berna Akinci , Ozdemirel Tugce Sahin , Akkurt Esma Sevil , Yenibertiz Derya , Saymaz Tilbe , Ozden Sertac Buyukyaylaci , Eroglu Zehra
Published: February 2021

ABSTRACT Aim: The aim of our research was to investigate retrospectively
the relationship between the symptoms and general characteristics,
initial laboratory values and treatments in patients who had COVID- 19
and who applied to the chest diseases outpatient clinic for control
after 1 month. Methods: Three hundred fifteen patients who were
diagnosed with COVID- 19 and applied to the chest diseases outpatient
clinic between May 2020 and August 2020 for control in the 1st month
were included in the study. Patient information was collected from the
hospital information system and the e-pulse system. Results: Females
accounted for 50.2 % of the our patients and their mean age was 47.98 ±
14.81 (19-88) years. 14.3% (n: 45) of the individuals were 65 years of
age and older. 20.6% (n: 65) of our patients were smoking. 70.2% (n:
221) of our patients were treated at home. 133 patients had at least one
comorbid disease. The patients most frequently reported cough, dyspnea,
weakness, myalgia and diarrhea. The most common symptoms were cough,
dyspnea, weakness and myalgia in the first month. It was determined that
the symptoms had persisted in patients who had been hospitalized, had
dual therapy, had comorbid diseases and had more common pathologies in
their pulmonary imagings. Conclusion: Symptoms may persist for a long
time in hospitalized patients, in patients with COVID-19-related
pneumonia and concomitant chronic diseases and in patients with high
d-dimer and high CRP at the time of admission. Patients are informed
that their symptoms may last for a long time, unnecessary hospital
admissons can be avoided.
Call the Coach: Opportunities and Challenges for Parent Coaching in Pediatric Type 1 Diabetes
Authors: Streisand Randi
Published: February 2021

Editor’s Note: This article was adapted from the address Dr. Streisand delivered as the recipient of the American Diabetes Association’s Richard R. Rubin Award for 2020. This award recognizes a behavioral researcher who has made outstanding, innovative contributions to the study and understanding of the behavioral aspects of diabetes in diverse populations. Dr. Streisand delivered the address in June 2020 at the Association’s virtual 80th Scientific Sessions.
COVID-19 Infection in An HIV-Positive Patient
Authors: Caskurlu Hulya , Cag Yasemin
Published: February 2021

The COVID-19 pandemic affects all age groups but follows a more mortal trajectory in patients with preexisting conditions such as immune deficiency, chronic lung disease, diabetes, and cardiovascular problems. Hence, HIV-positive patients with immune deficiency are at risk, therefore, these patients need to have continuous access to treatment during the pandemic. The number of defined COVID-19 positive HIV patients is very limited even though there are approximately 37.9 million HIV-positive patients globally. Therefore, we decided to publish this study reporting an HIV patient treated for COVID-19 in our clinic.
AGREEMENT OF SIMPLE COMPANY AND ITS TYPES: RUSSIAN LAW IN A COMPARATIVE LEGAL ASPECT
Authors: GOREVA A.A.
Published: February 2021

This article is devoted to the construction of a simple partnership agreement under Russian law. As a basis for the study, we took such key features of a simple partnership agreement as (1) association of persons, (2) making contributions and forming common property, (3) joint implementation of activities and (4) focus of activities on achieving a common goal. As a result of the analysis of these signs, it is possible to identify the shortcomings of the legal regulation of relations associated with a simple partnership agreement. Comparison of the legal regulation of a simple partnership agreement and its types: an investment partnership agreement, an agreement between participants in a syndicate of creditors, a mining partnership agreement shows that the use of the economic criterion in the construction of legislative material leads to various collisions.
A matter of scale
Authors: Luff Louise , Narayan Vickel
Published: February 2021

Teaching students ethical financial accounting practices and decision making can be complicated and challenging at good times. It requires the students to have a deep level understanding of the accounting requirements and professional values to be able to make fair and ethical judgements. However, for students who have no or little work experience making professional judgements without authentic contextual awareness and understanding may hold little significance (Mintz, 2019).

Moore (2013) elaborates that for students to develop financial reporting professional judgment proficiency they need to experience practical business world scenarios and learn to question and think as a professional financial accountant. He further argues that is imperative to develop these skills as these are pre-requisites for subsequent units of study and a graduate attribute expected by professional accounting bodies and employers.

In this session, we will discuss how we created an authentic and immersive case study for the students in collaboration with a professional accounting firm and other industry experts. We will discuss how authentic learning (Herrington, Reeves & Oliver, 2010) and heutagogic principles (Hase & Kenyon, 2000) were adopted in the design of the learning module to help develop critical thinking skills and understanding of connections within and implications from financial reporting professional judgements.

References:

Hase, S., & Kenyon, C. (2000). From andragogy to heutagogy. ultiBASE, 5(3).  Retrieved from http://ultibase.rmit.edu.au/Articles/dec00/hase2.htm

Herrington, J., Reeves, T. C., & Oliver, R. (2010). A guide to authentic e-learning (connecting with e-learning). New York: Routledge.

Mintz, S. (2019). A new approach to teaching ethical decision making to accounting students. The CPA Journal, Online.  Retrieved fromhttps://www.cpajournal.com/2019/10/14/a-new-approach-to-teaching-ethical-decision-making-to-accounting-students/

Moore, T. (2013). Critical thinking: seven definitions in search of a concept. Studies in Higher Education, 2013, Vol. 28, No 4, 506-522.
Telling Small Stories With Power Point As Video In Lockdown
Authors: Perry Jo
Published: February 2021

The 2020 pandemic and ensuing lockdowns came as a shock nationally and internationally. As a result, the change in approaches to teaching for many was fast and absolute. One minute the face-to-face ethos was humming along as 'normal', the next it was fully on line and taking teachers and students into a story many would never have considered. This brought with it the challenge of continuing to build and maintain relationships with the students in order to support their road to success. Storytelling has always been an important part of my practice in developing relationships through sharing my own experiences and encouraging the students to share theirs. In this way, we co-construct understanding of the class content and get to know each other. Going into fully online teaching would potentially change this.

 

Given the speed of the changes required, this project was never meant to be overtly innovative but was designed to allow me to continue using narratives of content and practice to build communities of learning in the online environment.  As a teacher, Power Point was familiar, so I started there and simply changed to saving them as mp4 files. 

 

The presentation plots this journey as a teacher taking storytelling from a face-to-face classroom across the lockdown in a way that continued supporting relationships and learning. The first attempts showed me that online stories are not the same as class power points where I physically created the narrative that linked the slides together.  As I viewed my first attempt, it became clear that I was trying to tell a story that was in my head but not translated to the screen and I needed to adopt an approach that clearly spoke to a listener/audience i.e. my community of learning.  I learned that, up to this point, I had used power point as a guide as I wove a story around the weekly content in a face-to-face classroom. In other words, the whole thing was heavily dependent on me.  In this new environment, the story had to be told in a different way.  It had to stand as a discrete artefact on its own, speaking to anyone that logged on, enabling me to reach out to that other human being without the unique connection that develops between story-teller and listener in the face to face world. Through three more cycles of research, I found that this new kind of story depended on a delicate balance between visual and oral, the context, content and the affective and how each was portrayed. Ultimately, the focus had to remain on the relationships I could build and the impact they could have. Therefore, this project came to be about keeping storytelling, whether face-to-face or online, “a uniquely human experience through which people make sense of past experience, convey emotions and ultimately connect with each other” (Christianson, 2011, p. 289).
Mobile Technology
Authors: Antonczak Laurent
Published: February 2021

The digital transformation of society is reaching a state of maturity, which provides people with new and exciting possibilities (NESTA, 2019) and implies a preponderant change in terms of inclusive collaboration, human-centred global economy and governance. Conjointly, ‘knowledge is the impetuous for communication’ (Carayannis & Clark, 2011, p. 203) with respect to foster ‘social capital’ and to thrive ‘cultural knowledge’ (Levallet & Chan, 2019, p. 182). Within this context, mobile technology, thanks to its affordance (Ahonen, 2011; Volkoff & Strong, 2013) and its contextuality (Cochrane et al., 2016), can enable creativity which supports the Cognitive Process Dimension (Anderson et al., 2001). Scilicet, mobile devices become the interface between people and processes (Morel et al., 2018; Dampérat et al., 2019) in relation to innovative practices (Makri et al., 2017) and real-world learning (Saleh et al., 2019) in formal and informal contexts. Moreover, it can enhance the developing of ideas inner/outer an organisation, or a classroom (Hall et al., 2020), and the serendipity flow of learning experiences (Makri et al., 2015). To a certain extent, mobile technology can bolster ‘collective knowledge’ (Pont, 2013; Levallet & Chan, 2019) by enabling quick decision-making and by connecting with a glocal network (Antonczak, 2021).

 

From a transdisciplinary approach, amidst learning sciences (Sommerhoff et al., 2018), management and organisational research, this presentation canvasses mobile technology (Jones & Marsden, 2006; Ahonen, 2011) as being a key apparatus and interface for collaborative innovation (Demil & Lecocq, 2012; Suire et al., 2018), which allows organisations to develop their ‘information ecology’ (Nardi, 1999) through a dynamic sense of what is inside and what is outside their boundaries. Said differently, it deciphers how mobile technology can enable exchange information and co-creative practices beyond formal structures and systems across industries and/or academia.

 

To start, the presentation quickly outlines some key concepts from an inter-disciplinary literature reviews (Baumeister & Leary, 1997), including collaboration, creativity, knowledge dynamics such as knowledge creation and/or conversion (Sawyer, 2008) as well as ‘knowledge retention and/or knowledge loss’ (Levallet & Chan, 2019). Next, it epitomises a few technological enabling conditions (Makri, 2017; Levallet & Chan, 2018; Cheng et al., 2019) such as autonomy, diversity, interactivity, contextuality through mobile social media and mobile-first applications (Apps) in relation to collaboration and learning practices beyond the limits of a physical environment. Then, it introduces the methodological and qualitative approach used for the analysis and findings, as well as the interpretations of practices in Education and Business. Finally, this presentation concludes with some features about how mobile technology practices support collaborative and innovative learning environments, the co-creation of new frameworks, and it suggests further avenues for supplementary research.
ISLAMICITY FINANCIAL PERFORMANCE INDEX PERBANKAN SYARIAH DI INDONESIA
Authors: Dinaroe Dinaroe , Mulya Indra , Mutia Evi
Published: February 2021

This research aims to examine the impact of Intellectual Capital and Good Governance Business Syariah (GGBS) towards Islamicity Financial Performance Index proxied by Profit Sharing Ratio (PSR). The data used is secondary data obtained from annual reports and the GCG implementation report that was published by the Islamic banks in the period of 2012 to 2016. This is a hypothesis testing research using purposive sampling method with 11 Islamic banks as the object of the research. The analysis method used is multiple regression analysis and the result partially shows that GGBS has a significant influence on Islamicity financial performance index, whereas intellectual capital does not.While, simultaneous testing shows both variables affect the islamicity financial performance index Islamic bank. Keywords: intellectual capital, GGBS, profit sharing ratio, Islamicity financial performance index  Abstrak Penelitian ini bertujuan untuk menguji pengaruh Modal Intelektual dan penerapan Good Governance Business Syariah terhadap Islamicity Financial Performance Index yang diproksikan dengan Profit Sharing Ratio (PSR). Data yang digunakan merupakan data sekunder yang berasal dari laporan tahunan (annual report) dan laporan pelaksanaan GCG yang dipublikasikan pada website masing-masing Bank syariah selama periode 2012-2016. Penelitian hipotesis ini menggunakan purposive sampling sebagai pengambilan sampel dengan 11 Bank Umum Syariah sebagai objek penelitian. Metode analisis yang  digunakan adalah analisis regresi linear berganda, dan hasil penelitian menunjukkan bahwa secara parsial modal intelektual tidak berpengaruh terhadap Islamicity Financial Performance Index perbankan syariah, sedangkan penerapan Good Governance Business syariah berpengaruh signifikan terhadap Islamicity Financial Performance Index. Pengujian secara simultan menunjukkan bahwa kedua variabel berpengaruh signifikan terhadap Islamicity Financial Performance Index Perbankan Syariah.
OPTIMIZATION OF HUMAN RESOURCES QUALITY IN IMPROVING THE PERFORMANCE OF ISLAMIC BANKING EMPLOYEES
Authors: Akbar Estelee Elora , Noviarita Heni , Anggraeni Erike
Published: February 2021

The purpose of this study was to find and review the optimization of human resourcesquality in improving the performance of Islamic banking employees. The approach used in this study was a quantitative approach by using primary data obtained through questionnaires to the Islamic banking customers located in Lampung. Sampling technique used in this studywas purposive sampling with a sample size of 100 people. Analysis of the data used in this study was simple linear regression analysis. Based on the result, the study found that there are significant quality of human resources in improving the performance of Islamic banking at 10.3%. Therefore,it needs to do the optimization of human resources quality through various efforts such as the recruitment system, the planning and training given by the company toward the employees, improving the intelligence, creativity, perseverance, as well as the professionalism of the employees.
PENJUALAN KONSINYASI PADA USAHA MIKRO, KECIL DAN MENENGAH DI KOTA LHOKSEUMAWE MENURUT PERSPEKTIF EKONOMI ISLAM
Authors: Jalaluddin Jalaluddin
Published: February 2021

Penelitian ini bertujuan untuk mengetahui apakah penjualan konsinyasi sesuai perspektif Ekonomi Islam pada Usaha Mikro Kecil dan Menengah (UMKM) Lhokseumawe-Aceh. Adapun jenis penelitian ini menggunakan penelitian studi lapangan dengan pendekatan kualitatif deskriptif. Teknik pengumpulan data yang digunakan adalah observasi, wawancara dan dokumentasi. Berdasarkan hasil penelitian diperoleh kesimpulan bahwa  penjualan konsinyasi pada UMKM Lhokseumawe-Aceh merupakan bentuk penerapan dari akad wakālah bil ujrah. Akan tetapi dalam pelaksanaan penjualan tersebut belum sepenuhnya sempurna sesuai dengan syariat Islam. Di mana dalam praktik pelaksanaannya terdapat tindakan wanprestasi yang dilakukan oleh pihak komisioner kepada pihak penitip berupa penundaan pembayaran hasil penjualan dari waktu yang telah disepakati dalam akad.
WAAM and Other Unconventional Metal Additive Manufacturing Technologies
Authors: Klobčar Damjan , Baloš Sebastijan , Bašić Matija , Djurić Aleksija , Lindič Maja , Ščetinec Aljaž
Published: February 2021

The paper presents an overview of metal additive manufacturing technologies. The emphasis is on unconventional emerging technologies with firm background on welding technologies such as Ultrasonic Additive Manufacturing, Friction Additive Manufacturing, Thermal Spray Additive Manufacturing, Resistance Additive Manufacturing and Wire and Arc Additive Manufacturing. The particular processes are explained in detail and their advantages and drawbacks are presented. Attention is made on materials used, possibilities to produce multi-material products and functionally graded materials, and typical applications of currently developed technologies. The state-of-the-art on the Wire and Arc Additive Manufacturing is presented in more detail due to high research interests, it’s potential and widespread. The main differences between different arc additive manufacturing technologies are shown. An influence of processing parameters is discussed with respect to process stability and process control. The challenges related to path planning are shown together with the importance of post-processing. The main advantage of presented technologies is their ability of making larger and multi-material parts, with high deposition rate, which is difficult to achieve using conventional additive technologies.
Ranga przedmiotu podstawy przedsiębiorczości w edukacji szkolnej
Authors: Kawecki Zygmunt
Published: February 2021

Od kilku lat w szkołach ponadgimnazjalnych pojawił się przedmiot podstawy przedsiębiorczości. Warto rozważyć jego rolę i miejsce w edukacji szkolnej. Zajmę się krótko trzema problemami:- rangą przedmiotu podstawy przedsiębiorczości w szkołach średnich,- metodyką nauczania przedsiębiorczości w szkole,- rolą nauczyciela przedmiotu podstawy przedsiębiorczości.
Technologia informacyjna a przedsiębiorczość w szkole ponadgimnazjalnej
Authors: Uczkiewicz Piotr
Published: February 2021

Rozwój społeczeństwa informacyjnego, rozwój cywilizacji naukowej i technicznej oraz globalizacja gospodarki – to trzy podstawowe czynniki zmian, mające wpływ na rozwój przedsiębiorstw i na system edukacji. Wszystkie wymienione czynniki przekładają się na zadania dla edukacji. Próbą odpowiedzi na nowe zmiany (równocześnie nowe wyzwania) jest przebudowa koncepcji edukacyjnych, która dokonuje się w polskim systemie edukacji...
The Growth, productivity and nutritional status of Salicornia brachiata Roxb. cultivated in saline soils supplemented with organic manures under sea water irrigation
Authors: Ramasubramanian Arumugam , Uyyavanthan Kavitha
Published: February 2021

Halophytic crops are being explored for their nutritional, culinary, oilseed, forage/ feed crop, medicinal, and wastewater treatment potential. Along the Palk Bay region, a short term field experiment was conducted at coastal inlands of Kattumavadi village of Puthukottai district, Tamilnadu during the monsoon season of 2017 to evaluate the cultivation potential of Salicornia brachiata Roxb. in coastal sandy loam soil supplemented with different rates of farmyard manure (FYM) and halophytic compost (HC) irrigated with seawater. Observations recorded in the present study clearly indicated that supplemental fertilizers can play a vital role in the restoration of soil fertility, particularly in terms of available nitrogen and organic carbon in saline soils. HC treated plants showed increased biomass production (3240 Kg ha-1) at 60 DAP compared to control and other treatments. The application of FYM @ 2 ton ha-1 and HC @ 1 ton ha-1 significantly enhanced dry matter production and the proximate analysis exhibited less variation in total phenols and ascorbic acid with the increase in the rates of manure applications.
Culture and social: herbal medicine as health communication to build urban community empowerment
Authors: Suharti Bangun , Kartika Tina , Sugiyanta Sugiyanta
Published: February 2021

This article discusses culture and social issues in the community related to herbal medicine used for health communication and community empowerment in Bandar Lampung. Additionally, herbal medicine plays a significant role in empowering families from the dependence of conventional medicine and developing traditional medicine. A good health level of community is an asset of Indonesia's human development that is independent, healthy, and strong. Using the qualitative research approach, the data source consisted of interviews, deep observations, and documentation. The results are herbal medicine 1) empowers the community for better family finance, 2) empowers people to get a job, 3) creates a new paradigm, making herbal medicine the first treatment choice when one is sick, instead of conventional medicine (medics). This study's findings describe the culture of the Indonesian people who are accustomed to drinking herbal medicine. Therefore, traditional herbal medicine needs to be empowered as a unique Indonesian culture, as it is possible to combine herbal and conventional medicines. This research contributes to policymakers to make herbal treatment models holistically, to support Program Indonesia Sehat (Indonesian General Health Program).
Mediciones de ritmo, grado de acento extranjero y fluidez discursiva
Authors: Luchini Pedro Luis
Published: February 2021

Durante mucho tiempo, la pronunciación en L2 estuvo relegada del currículo de la enseñanza de Lenguas Extranjeras. Sin embargo, con la aparición de la globalización y los nuevos avances tecnológicos, en la actualidad, el inglés se ha convertido en una lengua franca. Este nuevo contexto ha conllevado un cambio en el paradigma de la enseñanza de la pronunciación del inglés en el que resulta necesario garantizar la comunicación. Para ello, la pronunciación adquiere un rol protagónico, porque constituye el eje vertebral del habla. Por lo tanto, es necesario hacer una evaluación de los diferentes enfoques pedagógicos empleados para su enseñanza. El propósito de este estudio es evaluar dos propuestas pedagógicas para la enseñanza de la pronunciación en L2, utilizando mediciones de ritmo, acento extranjero y fluidez. Participaron dos grupos de estudiantes universitarios de habla hispana. Cada grupo fue expuesto a un tratamiento pedagógico diferente: A: enfoque tradicional, B: enfoque tradicional que integró un componente comunicativo. Los participantes grabaron pre- y post-tests, antes y después de los períodos de instrucción. Los resultados indicaron que el grupo expuesto al enfoque que incluyó el bloque comunicativo obtuvo mejores resultados que el otro. Finalmente, a la luz de los resultados, se discutirán algunas implicancias pedagógicas y sugerirán nuevos caminos de investigación en el área.
Educação em saúde acerca da violência contra a mulher: um relato de experiência
Authors: Barros Hyslla Maria de Oliveira , Reis Alizandra Mendonça , Lima Maria Inês Vieira de Oliveira , Pamplo Mônica Custódia do Couto Abreu , Peixoto Ivonete Vieira Pereira
Published: February 2021

Objetivo: Socializar experiência educativa em saúde, desenvolvida em prática curricular em Saúde Coletiva do curso de graduação em enfermagem, abordando a Violência Contra a Mulher (VCM). Relato de experiência: A ação foi realizada por acadêmicos do 7° período do curso de bacharelado em Enfermagem de uma faculdade do Estado do Pará, no qual foi realizada em uma Unidade Municipal de Saúde (UMS). As participantes foram mulheres usuárias do Sistema Único de Saúde (SUS), faixa etária entre 18 anos a 40 anos, que se encontravam na sala de espera para coleta do exame preventivo. A ação foi realizada utilizando tecnologias leves buscando facilitar o entendimento e estimular a participação das mulheres. Considerações finais: Por ser a atenção básica a porta de entrada do Sistema de Saúde ressalta-se a importância de realizar ações educativas para melhor atendimento das políticas pública a saúde das mulheres, esclarecimento sobre Violência Contra Mulher, minimizando índices de morbimortalidade feminina.
The potential of greenhouse diffusing cover material on yield and nutritive values of lamb’s lettuce grown under diverse nitrogen regimes
Authors: Cozzolino Eugenio , El-Nakhel Christophe , Ottaiano Eugenio , Di Mola Ida , Mori Mauro
Published: February 2021

Light and nitrogen are the main factors commanding horticulture production. Therefore, this study aims at evaluating the effects of two different greenhouse cover films (clear-Film A and diffuse light-Film B) on yield and nutritive value of a ready-to-eat salad lamb’s lettuce (Valerianella locusta L.), grown under several nitrogen regimes (no nitrogen [N0], sub-optimal [N25] and optimal N fertilization [N50] corresponding to 0, 25 and 50 kg ha-1 , respectively). The combination N50 and Film B boosted SPAD index by 10.3% and yield by 91.9% compared to N0 × Film A. Concerning antioxidant activity and bioactive compounds, only total ascorbic acid was positively affected by Film B (9.4%), while there was no effect of this cover film on carotenoids and chlorophyllous pigments, which increased along the increment of nitrogen rates. Nitrate content in leaves was influenced by both factors and it showed increasing values, when nitrogen doses increased, reaching the highest value under N50-Film B conditions (3312.3 mg kg-1 fw). Our study showed that in the Mediterranean area, the use of greenhouse diffuse light film improved lamb’s lettuce yield, but on the other hand incurred significant increase in nitrate level, nonetheless remaining constantly under the legal threshold imposed by the commission regulation (EU). Secondary metabolites, such as total phenols and carotenoids, showed similar values under both films, instead the diffuse light film improved total ascorbic acid content.
Total and diffuse light distribution within the canopy of an apple orchard as affected by reflective ground covers
Authors: Shtai Walaa , Petrillo Marta , Ben Abdelkader Walaa , Holtz Massimo
Published: February 2021

In recent years, anti-hail nets have been increasingly used to protect apple orchards. As they reduce the light intensity at canopy level, reflective ground covers are frequently placed on the soil surface before fruit harvest with the main aim to enhance color development in bicolored apples. It is not clear however, to which extent the light penetration inside the whole canopy is affected by the reflective ground covers. We performed a study in an intensively cultivated apple district of South Tyrol (northern Italy), with and without reflective ground covers. We measured light intensity at different heights from the ground and different distances from the tree trunk, using two instruments: an 80- cm long ceptometer and a point-like sensor capable of measuring the diffuse radiation component in addition to the total visible light. We found that the reflective ground cover significantly increased the quantity of diffuse light reflected from the orchard floor. The largest effect was recorded at 1 m height from the ground, but it was still significant at 2.5 m height. The influence of the reflective ground cover was particularly remarkable when sun and tree lines were aligned. The increase of total PAR inside the canopy due to the reflective material was however relatively small, suggesting a moderate effect on tree photosynthesis and therefore on apple yields.
Yield and quality performances of organic tomato as affected by genotype and industrial processing in southern Italy
Authors: De Sio Francesco , Sandei Luca , De Giorgi Francesco , Rapacciuolo Mariateresa , Tallarita Alessio , Morano Giuseppe , Cuciniello Antonio , Cozzolino Eugenio , Cenvinzo Vincenzo , Caruso Gianluca
Published: February 2021

Identifying new tomato (Solanum lycopersicum L.) genotypes with improved technological performances is an important requisite for achieving high yield and quality of industrial produce. An open-field experiment was carried out in southern Italy in order to assess the effects of three elongated tomato hybrids oriented to ‘peeled’ chain (Max 14802, Massaro, Taylor) in terms of crop productivity and nutritional value. The hybrid Taylor showed the highest marketable yield due to the highest fruit number, whereas Massaro showed the highest processing efficiency. Among the three genotypes compared, titratable acidity and fiber were highest in Max 14802 fruits (0.45 g anhydrous citric acid·100 g-1 and 0.94 g·100 g-1 respectively), Taylor was best ranking in terms of fat and sucrose content, and Massaro achieved the highest glucose, fructose and rutin accumulation. Compared to fresh fruits, peeled tomatoes attained higher values of total and soluble solids, reducing sugars, total polyphenols (referred to fresh weight), rutin and naringenin, but had a decreased value of colour coordinate a/b ratio. No significant differences between the three tomato cultivars were recorded in terms of sensorial traits. From the present research interesting clues have arisen regarding the best performances of the hybrid Taylor in terms of fruit yield and organic acid content, and of the hybrid Massaro regarding the processing efficiency and fruit health-beneficial properties.
Grover-based Ashenhurst-Curtis decomposition using quantum language quipper
Authors: Li Yiwei , Tsai Edison , Perkowski Marek , Song Xiaoyu
Published: February 2021

Functional decomposition plays a key role in several areas such as system design, digital circuits, database systems, and Machine Learning. This paper presents a novel quantum computing approach based on Grover’s search algorithm for a generalized Ashenhurst-Curtis decomposition. The method models the decomposition problem as a search problem and constructs the oracle circuit based on the set-theoretic partition algebra. A hybrid quantum-based algorithm takes advantage of the quadratic speedup achieved by Grover’s search algorithm with quantum oracles for finding the minimum-cost decomposition. The method is implemented and simulated in the quantum programming language Quipper. This work constitutes the first attempt to apply quantum computing to functional decomposition.
Simpler quantum counting
Authors: Wie Chu-Ryang
Published: February 2021

A simpler quantum counting algorithm based on amplitude amplification is presented. This algorithm is bounded by O(sqrt(N/M)) calls to the controlled-Grover operator where M is the number of marked states and N is the total number of states in the search space. This algorithm terminates within log(sqrt(N/M)) consecutive measurement steps when the probability p1 of measuring the state |1> is at least 0.5, and the result from the final step is used in estimating M by a classical post processing. The purpose of controlled-Grover iteration is to increase the probability p1. This algorithm requires less quantum resources in terms of the width and depth of the quantum circuit, produces a more accurate estimate of M, and runs significantly faster than the phase estimation-based quantum counting algorithm when the ratio M/N is small. We compare the two quantum counting algorithms by simulating various cases with a different M/N ratio, such as M/N > 0.125 or M/N < 0.001.
Quantum complexity associated with tunneling
Authors: Flom Ofir , Yahalom Asher , Zilberberg Haggai , Horwitz L.P. , Levitan Jacob
Published: February 2021

We use a one dimensional model of a square barrier embedded in an infinite potential well to demonstrate that tunneling leads to a complex behavior of the wave function and that the degree of complexity may be quantified by use of a locally defined spatial entropy function defined by S=-\int |\Psi(x,t)|^2 \ln |\Psi(x,t)|^2 dx . We show that changing the square barrier by increasing the height or width of the barrier not only decreases the tunneling but also slows down the rapid rise of the entropy function, indicating that the locally defined entropy growth is an essentially quantum effect.
Golden codes: quantum LDPC codes from regular tessellations of hyperbolic 4-manifolds
Authors: Londe Vivien , Leverrier Anthony
Published: February 2021

We adapt a construction of Guth and Lubotzky \cite{GL14} to obtain a family of quantum LDPC codes with non-vanishing rate and minimum distance scaling like n^{0.1} where n is the number of physical qubits. Similarly as in Ref.~\cite{GL14}, our homological code family stems from hyperbolic 4-manifolds equipped with tessellations. The main novelty of this work is that we consider a regular tessellation consisting of hypercubes. We exploit this strong local structure to design and analyze an efficient decoding algorithm.
A Benchmark of Electrostatic Methods Performance in Relative Binding Free Energy Calculations
Authors: Ge Yunhui , Hahn David F. , Mobley David
Published: February 2021

Relative free energy calculations are fast becoming a critical part of early stage pharmaceu- tical design, making it important to know how to obtain the best performance with these calculations in applications which could span hundreds of calculations and molecules. In this work, we compared two different treatments of long-range electrostatics, Particle Mesh Ewald (PME) and Reaction Field (RF), in relative binding free energy calculations using a non-equilibrium switching protocol. We found simulations using RF achieve comparable re- sults as those using PME but gain more efficiency when using CPU and similar performance using GPU. The results from this work encourage more use of RF in molecular simulations.
Progress Towards a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine
Authors: Ahlqvist Grace P. , McGeough Catherine P. , Senanayake Chris , Armstrong Joseph D. , Yadaw Ajay , Roy Sarabindu , Ahmad Saeed , Snead David R. , Jamison Tim
Published: February 2021

Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for treatment of COVID-19. Herein we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two steps: a selective enzymatic acylation followed by transamination to yield the final drug product. Both steps have been successfully performed on decagram scale: the first step at 200 g, and the second step at 80 g. Overall, molnupiravir has been obtained in a 41% overall isolated yield compared to a maximum 17% isolated yield in the patented route. This route provides many advantages to the initial route described in the patent literature and would decrease the cost of this pharmaceutical should it prove safe and efficacious in ongoing clinical trials.
Enzymatic RNA Production from NTPs Synthesized from Nucleosides and Trimetaphosphate
Authors: Chizzolini Fabio , Kent Alexandra , Passalacqua Luiz F. M. , Lupták Andrej
Published: February 2021

A mechanism of nucleoside triphosphorylation would have been critical in an evolving “RNA world” to provide high-energy substrates for reactions such as RNA polymerization. However, synthetic approaches to produce ribonucleoside triphosphoates (rNTPs) have suffered from conditions such as high temperatures or high pH that lead to increased RNA degradation, as well as substrate production that cannot sustain replication. We demonstrate that cyclic trimetaphosphate (cTmp) can react with nucleosides to form rNTPs under mild, prebiotically-relevant conditions, with second-order rate constants ranging from 1.7 x 10–6 to 6.5 x 10–6 M–1 s–1. The ATP reaction shows a linear dependence on pH and Mg2+, and an enthalpy of activation of 88 ± 4 kJ/mol. At millimolar nucleoside and cTmp concentrations, the rNTP production rate is sufficient to facilitate RNA synthesis by both T7 RNA polymerase and a polymerase ribozyme. We suggest that the optimized reaction of cTmp with nucleosides may provide a viable connection between prebiotic nucleotide synthesis and RNA replication.
Assembly of Model Membrane Nanodiscs for Native Mass Spectrometry
Authors: Kostelic Marius , Zak Ciara K. , Jayasekera Hiruni , Marty Michael
Published: February 2021

Native mass spectrometry (MS) with nanodiscs is a promising technique for characterizing membrane protein and peptide interactions in lipid bilayers. However, prior studies have used nanodiscs made of only one or two lipids, which lack the complexity of a natural lipid bilayer. To better model specific biological membranes, we developed model mammalian, bacterial, and mitochondrial nanodiscs with up to four different phospholipids. Careful selection of lipids with similar masses that balance the fluidity and curvature enabled these complex nanodiscs to be assembled and resolved with native MS. We then applied this approach to characterize the specificity and incorporation of LL-37, a human antimicrobial peptide, in single lipid nanodiscs versus model bacterial nanodiscs. Overall, development of these model membrane nanodiscs reveals new insights into the assembly of complex nanodiscs and provides a useful toolkit for studying membrane protein, peptide, and lipid interactions in model biological membranes.
Structure Revision of the Lomaiviticins
Authors: Kim Lee Joon , Xue Mengzhao , Li Xin , Xu Zhi , Paulson Eric , Mercado Brandon Q. , Nelson Hosea , Herzon Seth
Published: February 2021

The lomaiviticins are dimeric genotoxic bacterial metabolites that contain unusual diazocyclopentadiene functional groups and 2–4 deoxyglycoside residues. Because only 6 of 19 carbon atoms in the monomeric aglycon unit are proton-attached, their structure determination by NMR spectroscopic analysis is non-trivial. Prior structure elucidation efforts established that the two halves of the lomaiviticins are joined by a single carbon–carbon bond appended to an oxidized cyclohexenone ring. This ring was believed to comprise a 4,5-dihydroxycyclohex-2-en-1-one. The bridging bond was positioned at C6. This structure proposal has not been tested because none of the lomaiviticins have been prepared by total chemical synthesis or (to the best of our knowledge) successfully analyzed by X-ray crystallography. Here we disclose microED studies which establish that (–)-lomaiviticin C contains a 4,6-dihydroxy-cyclohex-2-en-1-one residue, that the bridging carbon–carbon bond is located at C5, and that the orientation of the cyclohexenone ring and configuration of the secondary glycoside are reversed, relative to their original assignment. High-field (800 MHz) NMR analysis supports the revised assignment and suggests earlier efforts were misled by a fortuitous combination of a nearzero 3JH4,H5 coupling constant and a 4-bond HMBC correlation that was interpreted as a 3-bond coupling. DFT calculations of the expected 13C chemical shifts of the original and revised structures of the aglycon and (–)-lomaiviticin B provide further robust support for the structure revision. Because the interconversion of lomaiviticins A, B, and C has been demonstrated, these findings apply to each isolate. These studies clarify the structures of this family of metabolites and underscore the power of microED analysis in natural products structure determination.
Synergistic Effect of Urease and Nitrification Inhibitors in the Reduction of Ammonia Volatilization
Authors: Hussain, Asim , Jabeen Zara , Afsheen Nadia , Rafiq Hamza , Huma Zill e , Rahman Khalil Ur , Naeem Muhammad , Hazafa Abu
Published: February 2021

Nitrogen (N) is deficient in more than 90% of soils of Pakistan mainly because of low organic matter contents. The use of nitrogenous fertilizers is a common practice for sustainable and profitable crop yields. A significant portion of added fertilizers is lost through volatilization, leaching, and denitrification. Low use efficiency of these fertilizers in our climate is a serious concern because of high costs and environmental issues. The present study evaluated the novel synergistic effect of urease and nitrification inhibitors such as ammonium thiosulfate (ATS) and 2-Chloro-6-(trichloromethyl)pyridine (Nitrapyrin) to reduce the urea hydrolysis in the soil of Faisalabad, Gujranwala, and Sheikhupura to manage the ammonia as well as N loss. Three different combinations such as A1, A2, and A3 of both inhibitors were prepared with different ratios of 1:1, 0.25:0.75, 0.75:0.25, respectively. Results showed that the minimum urea hydrolysis of about 2.41, 2.79, and 4.68 IU/g soil with A1 combination after 4th-day observation with the rate of 0.50% concentration for Faisalabad, Gujranwala, and Sheikhupura, respectively. In addition, results showed the better urease activity at a pH value of 6.50, incubation time of 30 min, and temperature of 37 ℃ for all A1, A2, and A3 combinations with 0.50% concentration. Moreover, inhibitors treated urea showed the plant maximum height of 111, 101, and 101 cm, and root length of 15, 11, and 5 cm, number of tillers of 14, 16, and 19 per panicle, and number of spikes of 37, 21 and 38 per panicle with A1, A2, and A3 combination at 0.50% dose respectively in Faisalabad soil. Overall, it is concluded that 0.50% inhibitor concentration showed the much impressive urease inhibition results followed by 0.25 and 0.10%. However, the application of inhibitors was a good practice to reduce the N loss from soil.
Open-Source Multi-GPU-Accelerated QM/MM Simulations with AMBER and QUICK
Authors: Cruzeiro Vinicius , Manathunga Madushanka , Merz, Jr. Kenneth M. , Goetz Andreas
Published: February 2021

The quantum mechanics/molecular mechanics (QM/MM) approach is an essential and well-established tool in computational chemistry that has been widely applied in a myriad of biomolecular problems in the literature. In this publication, we report the integration of the QUantum Interaction Computational Kernel (QUICK) program as an engine to perform electronic structure calculations in QM/MM simulations with AMBER. This integration is available through either a file-based interface (FBI) or an application programming interface (API). Since QUICK is an open-source GPU-accelerated code with multi-GPU parallelization, users can take advantage of “free of charge” GPU-acceleration in their QM/MM simulations. In this work, we discuss implementation details and give usage examples. We also investigate energy conservation in typical QM/MM simulations performed at the microcanonical ensemble. Finally, benchmark results for two representative systems, the N-methylacetamide (NMA) molecule and the photoactive yellow protein (PYP) in bulk water, show the performance of QM/MM simulations with QUICK and AMBER using a varying number of CPU cores and GPUs. Our results highlight the acceleration obtained from a single or multiple GPUs; we observed speedups of up to 38x between a single GPU vs. a single CPU core and of up to 2.6x when comparing four GPUs to a single GPU. Results also reveal speedups of up to 3.5x when the API is used instead of FBI.