bluuebunny/crossref_metadata_2025 huggingface dataset:
An Ensemble Learning based Technique for Bimodal Sentiment Analysis
Authors: Shah Shariq , Ghomeshi Hossein , Vakaj Edlira , Cooper Emmett , Mohammad Rasheed
Published: March 2023

Communication is a key method of expressing one's thoughts and opinions. Amongst many modalities, speech and writing are the most powerful and common forms of human communication. Analysing what and how people think has inherently been an interesting and progressive research domain. This includes bimodal sentiment analysis which is an emerging area in natural language processing (NLP) and has received a great deal of attention in recent years in a variety of areas including social opinion mining, health care, banking, and so on. At present, there are limited studies on bimodal conversational sentiment analysis as it proves to be a challenging area given the complex nature of the way humans express sentiment cues across various modalities. To address this gap, a comparison of the performance of multiple data modality models has been conducted on the MELD dataset, a widely-used dataset for benchmarking sentiment analysis within the research community. Our work then demonstrates the results of combining acoustic and linguistic representations. Lastly, our proposed neural network-based ensemble learning technique is employed over six transformer and deep learning-based models, achieving a State-Of-The-Art (SOTA) accuracy.
The Effects of Tourism on Local Development in Protected Nature Areas: The Case of Three Nature Parks of Sierra Morena (Andalusia, Spain)
Authors: Bahamonde-Rodríguez María , Šadeikaitė Giedrė , García-Delgado Francisco Javier
Published: March 2023

In rural spaces, new activities are developed to add to the traditional ones in the context of multifunctionality, considering the protection and enhancement of natural and cultural heritage, as in Nature Parks. They incorporate new recreational and tourist functions, understood as an instrument for local development. This research aims to study the relationships between tourism and local development in three Natural Parks (Sierra de Aracena and Picos de Aroche, Sierra Norte de Sevilla and Sierra de Hornachuelos) in Andalusia (Spain). The research uses a mixed methodology consisting of, on the one hand, selective interviews with stakeholders focused on tourism and local development processes and, on the other, secondary data to analyze the repercussions on local development. The results show that (1) prevalence among the informants of the economic dimension in local development above the environmental and socio-cultural dimensions; (2) influence of declarations of protection and implementation of development policies on the growth of the tourist offer; (3) uneven tourism development in the different municipalities and Natural Parks; and (4) limited effects of tourism on local development.
Design and Development of an Intelligent Clinical Decision Support System Applied towards the Diagnosis of Suspected Obstructive Sleep Apnea Patients from the Patient’s Health Profile and Symptomatology
Authors: Casal-Guisande Manuel , Ceide-Sandoval Laura , Mosteiro-Añón Mar , Torres-Durán María , Cerqueiro-Pequeño Jorge , Bouza-Rodríguez José-Benito , Fernández-Villar Alberto , Comesaña-Campos Alberto
Published: March 2023

Obstructive Sleep Apnea (OSA) is nowadays one of the respiratory pathologies with a higher in-cidence globally in developed countries. This situation led to an increase in the demand for medical appointments and diagnostic studies related to that condition, especially those based on poly-somnographies and cardiorespiratory polygraphies. These studies are limited in resources, causing long waiting lists with the subsequent impact on the patients’ health. Furthermore, it is necessary to mention that OSA’s symptomatology is not very specific, and it is typically present in the general population (excessive sleepiness, snore, etc.). In this regard, this paper proposes a novel intelligent clinical decision support system for the diagnosis of OSA which could be used to help medical teams, both in primary care settings and in units specialized in respiratory pathologies. The aim of the proposed system is to help discriminate the patients suspected of suffering from the pathology from those who are not. To this end, two types of information sets of heterogeneous nature are consid-ered. The first one encompasses objective data, related to the patient's health profile with infor-mation usually available in electronic health records. The second type comprises subjective data, referred to the symptomatology reported by the patient in a previous interview. To process the first group of information, a Machine Learning classification algorithm is used, Bagged Trees in this case. For processing the second information set, related with the symptomatology of the patient, a col-lection of expert systems based on fuzzy inferential systems arranged in cascade are employed. As a result, the system is able to determine two risk indicators related to the patient's risk of suffering from OSA: the Statistical Risk and the Symbolic Risk respectively. Subsequently, by interpreting both risk indicators mentioned it will be possible to determine the severity of the patients’ health, proposing a preliminary evaluation on their condition. For the initial tests of the system, a software artifact has been built using a dataset with 4,978 selected patients, suspected of suffering from OSA, from the Álvaro Cunqueiro Hospital in Vigo. The results obtained are promising, demonstrating the potential usefulness of this type of tools in medical diagnosis. Once the system has been validated with new data from clinical environments, it is considered as possible to obtain a relevant improvement in the quality of the healthcare services, and a reduction in the associated costs.
Recurrent Giant Cell Tumour of the Calcaneum - A Case Report
Authors: S Varun Roheet S , Prakash Siva , R Balaji , Ramesh Chepauk , Kannan Arun
Published: March 2023

Introduction - A 20-year-old female who presented with multiply recurrent giant cell tumour (GCT) of the left calcaneum and destruction of talus. To our knowledge, there has been no literature published on the method for reconstruction of the hind foot after complete removal of both calcaneum and talus.
Case presentation - She was managed with an en-bloc talocalcaneal resection and reconstruction with femoral head allograft. She developed soft tissue recurrence at one year and was managed with wide excision of the soft tissue component and flap coverage.
Conclusion - At 5 years follow up, she was free of recurrence and had painless ambulation.This case illustrates successful use of femoral head allograft for reconstruction of both talus and calcaneum, and management of soft tissue recurrence with wide local excision.
WITHDRAWN: Effects of AMV and WCMV combined infection on the chloroplasts ultrastructure in Nicotiana benthamiana
Authors: CHEN ying-e , LIANG Qiao-lan , WEI Lie-xin , CHENG shou-feng
Published: March 2023

In order to clarify the synergism pathogenic mechanism of alfalfa mosaic virus (AMV) and white clover mosaic virus (WCMV) combined infection Nicotiana benthamianaunder indoor conditions, In this experiment, the effect of AMV and WCMV combined infection on the chlorophyll content, morphology and microstructure in N. benthamiana, the relative expression of the two viruses at different infected times were observed. The results showed that AMV and WCMV combined infection the chlorophyll content was significantly lower than that in N. benthamianaalone infection and healthy; electron microscopy observed the cytoplasmic ultralesions found that two forms of viruses in the AMV and WCMV combined infection of N. benthamiana, the length of bacillus virus was 20~75 nm observed in AMV alone infection, the length of linear virus was 400~600 nm observed in WCMV alone infection; after the AMV and WCMV combined infection of N. benthamiana, chloroplasts showed cleavage, osmium granules, mitochondrial crest voids increased, mitochondrial malformations were serioused, the chloroplasts internal layer structure was loose and flocculent in N. benthamiana by AMV、WCMV alone infection; real-time quantitative detection showed that the relative expression of AMV and WCMV reached the maximum on the 21 d, which increased by 39.46% and 31.53% compared with AMV and WCMV alone infection.
Preparation of low internal resistance electrode material with multistage interconnected pores from coffee grounds
Authors: Li Bin , Li Jian , Guo Minghui
Published: March 2023

Using biomass waste materials to prepare electrode materials with excellent properties is an effective strategy for solving current energy and environmental problems. In this work, coffee grounds were pretreated with Co(NO3)2 and Ni(NO3)2, then KOH was used to activate the pretreated coffee grounds at a high temperature to obtain a foam-like electrode material with interconnected microporous-mesoporous-macroporous hierarchical channels. This preparation method is simple and has low energy consumption, and the resulting material has an ultra-low internal resistance of 0.31 Ω. The specific capacitance of CGC-2 is 302.65 F g− 1 at a current density of 1 A g− 1. The low internal resistance and high electrical conductivity of this activated material are attributed to the presence of Co2+ and Ni2+ during carbonization, whose catalytic effect leads to a relatively ordered lattice structure. The interconnected structure of the final product is mainly caused by the strong activation function of KOH generating many pores. The prepared material exhibits good rate performance and cycling stability, and it has a Coulombic efficiency of nearly 100%. This work provides a novel idea for using biomass materials to fabricate high-performance electrode materials for supercapacitors.
Association between cooking patterns and hyperlipidemia in Eastern China
Authors: Cui Bin , Yuan Wen Kai , Wang Linda Dong-Ling , Wang Fu Rong , Peng Jing , Ma Jian Ying , Chen Xiang , Xu Mei Yin , Ke Jun , Tian Yi
Published: March 2023

Background: Hyperlipidemia is a major risk factor for many diseases. Previous studies have shown that diet is closely associated with hyperlipidemia. However, the relationship between cooking methods and hyperlipidemia remains unclear. The objective of this study was to identify the major cooking patterns existing in the Eastern Chinese population and evaluate their association with the risk of hyperlipidemia.
Methods: We interviewed 4,710 residents in Eastern China regarding the consumption frequency of each cooking method when they prepare food at home or when eating out and regarding the prevalence of hyperlipidemia. Factor analysis, Chi-square test, analysis of variance, and binary logistic regression analysis were used to identify the cooking patterns and analyze the characteristics of participants’ categories of cooking patterns and the relationship between different cooking patterns and hyperlipidemia.
Results: Three major cooking patterns were identified: Traditional Chinese, Bland, and High-temperature cooking patterns. After controlling for potential confounders, participants in the highest quartile of the Bland cooking pattern had lower odds of hyperlipidemia than those in the lowest quartile. Nevertheless, no significant associations were observed between the Traditional Chinese and High-temperature cooking patterns and the risk of hyperlipidemia.
Conclusions: This study confirms the association between cooking patterns and the risk of hyperlipidemia and indicates that the Bland cooking pattern is associated with a reduced risk of hyperlipidemia.
The role of BFGF-related transcriptional regulation and alternative polyadenylation in calcification model of valve interstitial cells induced by osteoblastic medium
Authors: Zhang Jiajun , Wu Jun , Gao Yuan , Fan Xingli , Liu Xiaohong , Zhang Guanxin , Tang Yangfeng , Han Lin
Published: March 2023

Objective
Calcific aortic valve disease (CAVD) is a major cause of aortic stenosis resulting in angina, heart failure, and death. However, the molecular mechanism of its progression, especially the sophisticated disease-related transcriptional regulation machinery remains to be further elucidated.
Methods
This study was modeled on porcine valvular interstitial cells (PVIC). We used OIM to induce calcification and bFGF treatment to inhibit calcification. The mRNA expression profile of PVICs and their related transcriptional regulation were investigated using transcriptome sequencing. We used DaPars to further examine alternative polyadenylation (APA) among the different treatment groups.
Results
We identified global APA alteration in the OIM, OIM-bFGF, and Ctrl treatment groups. We also identified the CAT gene as one of the crucial candidate genes that may contribute to calcification inhibition through APA regulation. The alteration of both APA and protein levels of the CAT gene in the bFGF-treated group was further validated using qRT-PCR and western blotting analysis.
Conclusion
We described a global APA change in a calcification model related to CAVD. We revealed that transcriptional regulation of the CAT gene may contribute to bFGF-induced calcification inhibition.
Drug-induced bilateral ciliochoroidal detachment and uveitis in a patient with COVID-19
Authors: yao Huiping , Chen Yanwei , Zhou Yufeng , Liu Xiaoqing , Shen Xi
Published: March 2023

Background: To describe a case of bilateral transient myopia with shallow anterior chamber, ciliochoroidal detachment and uveitis in both eyes induced by indapamide intake following SARS-CoV-2 infection.
Case presentation: A 37-year-old man with COVID-19 was referred to our department for bilateral visual blurring. He had been treated with ibuprofen for fever and indapamide to treat the uncontrolled blood pressure. After indapamide intake for four days, he started complaining of bilateral visual blurring. On ocular examination, the uncorrected visual acuity was 20/400 OD and 20/400 OS. Slit-lamp examination revealed shallow anterior chamber. In the patient’s subsequent visit on the next day, he complained of pain and redness in both eyes from the previous night. On ocular examination, the IOP decreased significantly compared to the previous day, 11 mmHg and 12 mmHg in OD and OS respectively. Slit-lamp examination revealed conjunctival injection and inflammatory cells (2+) in the shallow anterior chamber of both eyes. Ultrasound biomicroscopy revealed ciliary body detachment, and B-scan ultrasound showed peripheral shallow choroidal detachment in both eyes. Stopping the indapamide and treatment with oral prednisolone, topical tobramycin dexamethasone and tropicamide phenylephrine eye drops resulted in rapid recovery of the signs and symptoms after 3 days.
Conclusions: Indapamide intake can induce bilateral shallow anterior chamber, ciliochoroidal detachment in both eyes, and the preexisting hyperinflammation induced by COVID-19 might increase the susceptibility; drug usage and SARS-CoV-2 infection might commonly contribute to the uveitis. Timely diagnosis and treatment can result in good prognosis.
piRNA hsa_piR_019914 promoted chondrocyte anabolic metabolism by inhibiting LDHA-dependent ROS production
Authors: Gao Yuxuan , Yan Wen , Sun Liangye , Zhang XiaoLing
Published: March 2023

Objectives
As a new molecular marker and therapeutic target, Piwi-interacting RNA(piRNA) has been widely studied in the field of oncology, but few people have studied the role of piRNA in osteoarthritis. Here, we found that the expression of hsa_piR_019914 in human osteoarthritis cartilage decreased significantly. We studied the relationship between hsa_piR_019914 and gene expression in osteoarthritis cartilage and the role of hsa_piR_019914 in chondrocyte biology. It is suggested that hsa_piR_019914 may be a new target for the treatment of osteoarthritis.
Design
Using the GEO database to analyze the expression of piRNA in the cartilage of osteoarthritis, using qPCR to detect the effect of inflammatory factors on the expression of piRNA in chondrocytes, using CCK-8 and clone formation to detect the effect of hsa_piR_019914 on chondrocyte proliferation, and using flow cytometry to detect the effect of hsa_piR_019914 on chondrocyte apoptosis and ROS production. The target gene of hsa_piR_019914 regulation was detected by mRNA sequencing.
Results
GEO data analysis found that 11 piRNAs were downregulated in cartilage tissue of osteoarthritis, and inflammatory factors inhibited the expression of hsa_piR_019914 in chondrocytes. Hsa_piR_019914 promoted the proliferation of chondrocytes and the synthesis of extracellular matrix. Hsa_piR_019914 inhibited the apoptosis of chondrocytes and the expression of cell-matrix protease. Hsa_piR_019914 targets regulating the expression of LDHA and inhibiting the production of ROS.
Conclusions
This work highlights the role of hsa_piR_019914 in chondrocyte metabolism, the inhibition of LDHA, and the reduction of ROS production, which may be used as a potential treatment for osteoarthritis.
Electroacupuncture versus sham electroacupuncture in the treatment of female stress urinary incontinence: a randomized controlled trial protocol
Authors: Wang Xi , Hu Junwei , Song Xiuling , Ming Shuren , Li Juanjuan , Xu Ge , Zhang Xia , Chen Yuelai
Published: March 2023

Background: Stress urinary incontinence (SUI) is defined as involuntary leakage of urine due to increased abdominal pressure. Previous studies have confirmed that electroacupuncture is an effective alternative approach for treating SUI; yet, objective evidence of its mechanism of action is still lacking. Patients with SUI often harbor structural changes in the pelvic floor, which can be easily detected on transperineal ultrasound (TPUS). The aim of this study was to assess the effect of electroacupuncture involving the lower abdomen, compared with sham electroacupuncture in women with SUI, and observe changes in pelvic floor structure by TPUS.
Methods: Seventy-four female patients with SUI will be included in this study and randomly assigned to the test and control groups at a 1:1 ratio. Both groups will be treated with pelvic floor muscle training. In addition,patients in the test group will be subjected to electroacpuncture (EA) (at Zhongji (RN3), Guanyuan (RN4), and Dahe (KI12) acupoints), while the control group will be subjected to sham electroacupuncture (SEA) at same acupoints. Bothgroups will be treated three times a week for 6 weeks. The primary outcomes include change from baseline to week 6 in the bladder neck descent (BND) and the urine leakage measured by the 1-h pad test. Secondary outcomes include an objective degree of incontinence, subjective severity of incontinence, ICIQ-SF score, mean 24-h incontinence episodes, and subjective evaluation of incontinence leakage degree. TPUS will be used to observe the changes of parameters on the pelvic floor structure, such as urethral rotation angle (URA), retrovesical angle (RVA), the bladder neck position (BN-S), urethral funneling, and bladder bulging. The safety evaluation, and participant acceptance evaluation of the treatment will also be performed.
Discussion: The study may help objectively document the efficacy of electroacupuncture in SUI and clarify its mechanism of action.
Trial registration: Registration in the Chinese Clinical Trial Registry (ChiCTR2100050792)(http://www.chictr.org.cn/showproj.aspx?proj=132759),was effective September 4, 2021.
Just-in-time Adaptive Intervention for Stabilising Sleep Hours of Japanese Office Workers: A Micro-randomised Trial
Authors: Takeuchi Hiroki , Ishizawa Tetsuro , Kishi Akifumi , Nakamura Toru , Yoshiuchi Kazuhiro , Yamamoto Yoshiharu
Published: March 2023

Sleep disturbance is a major contributor to future health and occupational issues. Mobile health (mHealth) can provide interventions that address adverse health behaviours for individuals in vulnerable health state, in real-world settings (just-in-time adaptive intervention, JITAI). Here, Japanese office workers were instructed to collect data on their habitual sleep behaviours (including sleep hours, midpoint of sleep, and sleep efficiency) and momentary symptoms (including depressive mood, anxiety, and subjective sleep quality) using digital devices in a real-world setting. In study 1, we utilised these data to identify a subpopulation that had problems in habitual sleep behaviours and found that unstable sleep hours were associated with disturbed momentary symptoms. Based on these findings, in study 2, we designed and conducted a sleep JITAI, which delivered objective push-type sleep feedback for stabilising their sleep hours, for some participants in study 1. Moreover, we employed micro-randomisation to examine the within-individual proximal effects of the intervention. Providing sleep feedback prolonged subsequent sleep hours, but this effect was attenuated over time. Changing sleep hours improved depressive mood and subjective sleep quality. Participants in study 2 had more stabilised sleep hours than those in study 1. This is the first mHealth study to demonstrate that sleep feedback proximally and distally improves sleep behaviours in a micro-randomised trial. The findings of this study encourage the use of digitalised health intervention trials that employs real-time health monitoring and personalised feedback.
Human papillomavirus self-sampling and urine-sampling tests and the management and short-term outcomes of cervical intraepithelial neoplasia: A prospective observational study
Authors: Matsuura Motoki , Tamate Masato , Nagao Sachiko , Kurokawa Shoko , Nishimura Yoko , Isoyama Kyoko , Akimoto Taishi , Kasuga Fukiko , Shimada Hiroshi , Wada Nagisa , Shikanai Satoshi , Jin Miona , Tabuchi Yuta , Teramoto Mizue , Saito Tsuyoshi
Published: March 2023

Background: The importance of human papillomavirus (HPV) co-testing using physician-, self-, and urine-collected samples to predict cervical intraepithelial neoplasia (CIN) grade 1–2 prognoses has not been previously reported. Therefore, this study aimed to investigate the outcomes of patients with CIN 1–2 who simultaneously underwent physician-, self-, and urine-collection sampling tests.
Methods: This study was conducted in Japan between October 2019 and November 2022 and examined the proportion of cases with CIN 1–2 progressions, the percentage of cases with persistent CIN 1–2, and the outcome differences according to the results of physician-, self-, and urine sampling tests.
Results: There were 105 and 59 CIN 1 and 2 cases, with progression or persistence in 27 (29.3%) and 21 (50.0%) cases, respectively. The median follow-up was 20 and 12 months, respectively. Progression and persistence of CIN 1 were significantly associated with HPV-positive physician- and self-collection samples. No significant difference was observed between cases with CIN 2 who had HPV-positive and HPV-negative results using any sampling method.
Conclusions: Physician- and self-testing for HPV are crucial for predicting disease progression risk in CIN 1 cases. Future research with an extended observation period and consideration of the progression risks is warranted.
Annotation of Trauma-related Linguistic Features in Psychiatric Electronic Health Records for Machine Learning Applications
Authors: Holderness Eben , Atwood Bruce , Verhagen Marc , Shinn Ann , Cawkwell Philip , Pustejovsky James , Hall Mei-Hua
Published: March 2023

Psychiatric electronic health records (EHRs) present a distinctive challenge in the domain of ML owing to their unstructured nature, with a high degree of complexity and variability. This study aimed to identify a cohort of patients with diagnoses of a psychotic disorder and posttraumatic stress disorder (PTSD), develop clinically-informed guidelines for annotating these health records for instances of traumatic events to create a gold standard publicly available dataset, and demonstrate that the data gathered using this annotation scheme is suitable for training a machine learning (ML) model to identify these indicators of trauma in unseen health records. We created a representative corpus of 101 EHRs (222,033 tokens) from a centralized database and a detailed annotation scheme for annotating information relevant to traumatic events in the clinical narratives. A team of clinical experts annotated the dataset and updated the annotation guidelines in collaboration with computational linguistic specialists. Inter-annotator agreement was high (0.688 for span tags, 0.589 for relations, and 0.874 for tag attributes). We characterize the major points relating to the annotation process of psychiatric EHRs. Additionally, high-performing baseline span labeling and relation extraction ML models were developed to demonstrate practical viability of the gold standard corpus for ML applications.
Association of a decreased platelet count with poor survival in patients with adult secondary hemophagocytic lymphohistiocytosis
Authors: Cheng Wanying , Xu Ji , Shu Yongqian , Qiu Hongxia , Yin guangli
Published: March 2023

Purpose
We aimed to examine the association between baseline platelet count (PLT) and the prognosis of adult secondary hemophagocytic lymphohistiocytosis (sHLH).
Material and methods
Data from 292 patients with pretreatment platelet counts were retrospectively analysed from January 2016 to December 2020. We categorized platelet count into quartiles. Multivariable Cox proportional hazards models and restricted cubic splines (RCS) were used to evaluate the relationship between platelet count and mortality.
Results
During a median follow-up of 53 (interquartile ranges, 17–223) days, a total of 208 deaths occurred. After multivariable adjustment, a nonlinear and inverse relationship was observed for mortality (P for nonlinearity = 0.002). For non-LHLH, a similar curve was also observed (P for nonlinearity = 0.028). Decreased PLT ((PLT Q4)) was associated with an increased risk of mortality (adjusted hazard ratio: 1.97; 95% confidence interval: 1.28–3.04; Ptrend =0.005). Similar results were observed in the LHLH subgroup (adjusted hazard ratio: 1.84; 95% confidence interval: 1.05–3.24; Ptrend =0.024) but not in the non-LHLH subgroup (Ptrend =0.266).
Conclusions:
Baseline platelet count demonstrated a nonlinear and inverse association with an increased risk of mortality among adult sHLH patients. This method is used to identify sHLH patients with inferior overall survival due to its low cost and universal availability.
WITHDRAWN: On the numerical solution of high order stable difference schemes for nonlinear system of sine-Gordon equations in the weak sense
Authors: Yildirim Ozgur
Published: March 2023

In the present paper numerical solution of the coupled system of sine-Gordon equations are studied in the weak sense. A first order and two second order of accuracy unconditionally stable difference schemes corresponding to the system of sine-Gordon equations are considered. Solutions of these difference schemes are obtained in the space of distributions by variational methods. The fixed point theory and finite difference method is used together in the implementations of numerical experiments which verify theoretical statements.
Light treatment ameliorates sub-chronic MK-801-induced cognitive deficits in mice through up-regulating BDNF/p-CREB/p-ERK signaling pathway
Authors: Cui Keke , Zhou Yiying , Zhang Lizhi , Ying Yudong , Xue Yan , Gu Jiajie , Zhang Xiaoqin , Wang Qinwen , Shen Haowei , Zhou Wenhua , Wang Zhengchun
Published: March 2023

Cognitive impairment associated with schizophrenia (CIAS) is regarded as a core symptom of the illness, and there is still no effective treatment. Light plays an important role in regulation of cognitive functions. However, whether light treatment (LT) can improve CIAS remains unknown. The current study investigated the efficacy of LT on CIAS and explored the underlying molecular mechanisms in a CIAS model. The CIAS and control group were sub-chronically injected with MK-801 and saline respectively, and the LT/CIAS group were CIAS mice exposed to LT (3,000 Lux, 2 hr/day, 3 weeks). Results showed that the performance of LT/CIAS mice significantly improved in the novel object recognition test, novel location recognition test and Morris water maze compared with the CIAS group. And the behavioral improvement effects of LT could last over 4 weeks after LT was terminated. Golgi-cox staining revealed that the dendritic spine density and morphological complexity of hippocampal CA1 pyramidal neurons were increased after 3 weeks LT. Further research found that higher expression of brain-derived neurotrophic factor (BDNF), accompanied by elevated cAMP response element-binding phosphorylation (p-CREB) level in the hippocampus of LT/CIAS group compared to the CIAS group. Moreover, LT elevated phosphorylated extracellular signal-regulated kinase (p-ERK) level in the hippocampus of LT/CIAS group compared to the CIAS group. Taken together, long term LT ameliorated sub-chronic MK-801-induced cognitive deficits in mice, and the altered dendritic spines density and morphology of CA1 pyramidal neurons were rescued in LT/CIAS mice group, which might associate with up-regulating BDNF/p-CREB/p-ERK signaling pathway in LT/CIAS mice.
Adult child socio-economic status and older parents’ psychosocial outcomes during the COVID-19 pandemic
Authors: Romero K. Renata Flores , Yang Yulin , Green Sharon H. , Gutierrez Sirena , Meza Erika , Torres Jacqueline M.
Published: March 2023

Purpose Older adults’ psychosocial outcomes during the COVID-19 pandemic have been inequitable by socio-economic status (SES). However, studies have focused solely on own SES, ignoring emerging evidence of the relationship between adult child SES and late-life health. We evaluated whether adult child educational attainment – a core marker of SES – is associated with older parents’ psychosocial outcomes during the pandemic.
Methods We used data from the Survey of Health, Aging, and Retirement in Europe (SHARE; 2004-2018) and the SHARE Corona Surveys (2020 and 2021). We included 15,553 respondents > 65 years who had pre-pandemic information on adult child educational attainment, self-reported mental health, and worsened mental health compared to the pre-pandemic period. We used generalized estimating equations adjusted for respondent and family-level characteristics, including respondents’ own SES.
Results Older adults whose adult children averaged levels of educational attainment at or above (vs. below) their country-specific mean had a lower prevalence of nervousness (Prevalence Ratio [PR]: 0.95, 95% Confidence Interval [CI]: 0.91, 0.99), depression (PR: 0.96, 95% CI: 0.92, 1.00), and trouble sleeping (PR: 0.96, 95% CI: 0.92, 1.00) during the pandemic; associations with loneliness were null. Overall associations with worsened mental health as compared to the pre-pandemic period were null. Protective associations were stronger in countries experiencing “high” levels of COVID-19 intensity.
Conclusions Adult child SES may be an important driver of inequities in older adults’ mental health during the COVID-19 pandemic. Policies aimed at improving adult child SES may buffer the adverse psychosocial impacts of societal stressors.
The predictive effect of nomogram constructed based on peripheral blood biochemical indicators on the prognosis of patients with gastric cancer after surgery
Authors: He Shui , Yan Zhi-Qiang , Wang Yang , Shi Qian-Yun , Nie Wei , Yang Fang
Published: March 2023

Objective To investigate the predictive value of aspartate aminotransferase/alanine aminotransferase ratio (SLR) and globulin/prealbumin ratio (GPR) in the prognosis of patients with gastric cancer.
Methods The patients with gastric cancer initially diagnosed at the Affiliated Hospital of Guizhou Medical University from January 2014 to December 2018 were retrospectively analyzed for peripheral blood aspartate aminotransferase and alanine aminotransferase ratio (AST/ALT) and globulin and prealbumin ratio (GLO/PA) serological levels at the time of initial diagnosis, and ROC curves were used to obtain the optimal threshold values of AST/ALT and GLO/PA . Survival rates were compared using Kaplan-Meier survival analysis, and Cox regression models were used for univariate and multivariate analyses, with differences considered statistically significant at P<0.05. A nomogram model for assessing OS-related prognostic factors was established using R software. The performance of the nomogram model was assessed by means of the consistency index (c-index) and the decision curve.
Results The threshold value of SLR was calculated from the ROC curve as 1.433, and the threshold value of GPR was 0.109. Univariate analysis showed that the poor prognostic factors affecting the 3-year OS rate of gastric cancer patients included T grouping, N grouping, M grouping, clinical-stage grouping, SLR grouping, GPR grouping, and tumor size grouping, and the differences were statistically significant (P<0.05). Multifactorial analysis showed that N2-N3 stage, M1 stage, and SLR> 1.433 were independent risk factors for poor prognosis of 3-year OS in gastric cancer patients. It was further used to construct the nomogram prediction chart, calculate the c-index and depict the calibration curve to judge the accuracy of the model, and depict the decision curve to judge the predictive ability of the model.
Conclusion The nomogram prediction chart including SLR can more accurately predict the prognosis of gastric cancer patients.
Exploring potential diagnostic and therapeutic targets for glioma based on the prognostic model of differential expression of pyroxis-related genes
Authors: Yuan Zhengbo , Li Chenglong , Wang Qingbo , Li Zefu
Published: March 2023

Background: Adult glioma is the most common primary nervous system tumor, and there is a direct link between the grade of glioma and the patient's prognosis. Furthermore, its treatment is still very challenging. Pyroptosis is another research direction that has made breakthroughs in recent years, and it has been confirmed that it plays an essential role in various tumors. We are currently focusing on analyzing the data, and clinical data of a large number of pyroptosis genes, exploring the regulatory mechanism of tumor cell pyroptosis and the potential role of pyroptosis in cancer in order to explore potential cancer diagnosis and treatment markers for The pursuit of personalized or precise treatment provides new ideas and directions.
Design: Bioinformatics analysis of GEO database,TCGA database and GSEA data.
Methodology: Differential gene expression, Prognostic Network Construction, Construction of a prognostic model, Differential analysis of tumor microenvironment, immune cell expression, Tumor mutation burden correlation analysis, stem cell correlation analysis, and drug sensitivity analysis.
Conclusions: We have identified differential genes with high mutation frequencies in adult gliomas and critical genes associated with cell scorch and differentially expressed in a different extent of malignant glioma. We are combined with the construction of prognostic models and other methods to reveal potential prediction and therapeutic targets of glioma.
Global Mobility Networks: Design and Development of a Secure and Lightweight Authentication Protocol
Authors: Padmavathi V , Kanimozhi R
Published: March 2023

The increasing use of mobile devices and wireless networks has led to the development of global mobility networks, which enable users to access services and data from anywhere in the world. However, ensuring the security of these networks is a major challenge, as they are vulnerable to various attacks such as eavesdropping, impersonation, and data tampering. To address this challenge, this paper proposes a secure and lightweight authentication protocol for global mobility networks, based on two established cryptographic techniques: the Extensible Authentication Protocol - Transport Layer Security (EAP-TLS) and the Elliptic Curve Digital Signature Algorithm (ECDSA). The proposed authentication protocol consists of several key steps, including user registration, certificate distribution, mutual authentication, and session key generation. The protocol uses EAP-TLS to establish a secure channel between the client and the server, and ECDSA to provide secure digital signatures and key generation. The use of ECDSA ensures that the protocol is resistant to various attacks, such as replay attacks and man-in-the-middle attacks. Additionally, the use of EAP-TLS provides mutual authentication between the client and the server, preventing impersonation attacks. The proposed authentication protocol is designed to be lightweight and efficient, making it practical for use in resource-constrained environments such as mobile devices and wireless networks. The protocol has been evaluated through simulations, and the results demonstrate that it provides strong security guarantees while also being efficient in terms of computational resources and communication overhead. Overall, the proposed authentication protocol provides a practical solution for ensuring the security of global mobility networks, while also being lightweight and efficient enough to be used in resource-constrained environments.
Modeling and Simulation of Coupled Power Transmission Line: A Systematic Approach
Authors: Living O. , Nnamchi S. N. , Mundu M. M. , Ukagwu K. J. , Abdulkarim A.
Published: March 2023

Transmission models are dominated by lumped models, which describe the time dependence of transmission potentials (temperature, current and voltage). The space counterpart is not incorporated into the lumped model. To fill this gap, the present work proposes a distributed or coupled system of thermal and power equations, which depend on both space and time. The coupled system of equations were developed on the balance of thermal and power fluxes around a control volume representing the transmission lines. The Finite Difference Method is pivoted on the Crank Nicolson technique is used to solve the coupled system of equations. Transmission percentage losses ranged from 0.03 to 0.06%, which is consistent with the 5% recommended by the American Transmission Company. In addition, the simulated model results corresponded to field data obtained from the Uganda Electricity Transmission Company Limited (UETCL) on the Bujjagali - Kawanda transmission line. The coupled model system is useful for the simulation and estimation of the power losses in transmission lines respectively and could be implemented in other transmission lines.
Research landscape of radiotherapy for nasopharyngeal carcinoma from 1959 to 2022: a bibliometric analysis.
Authors: Yang Yizhou , Yang Xinqing , Zhang Cuidai , Huang Kaichun , Liu Xuejia , Hong Yingji , Cai Qingxin , Li Mei , Lin Zhixiong
Published: March 2023

Background
Radiotherapy, as the main treatment method for nasopharyngeal carcinoma (NPC), has been innovating over time and no bibliometric study on NPC radiotherapy to date. In the study, the scientific achievements of NPC radiotherapy around the world were evaluated by bibliometric analyses, and the previous research hotspots and future trends were described.
Methods
Original articles related to NPC radiotherapy were obtained from the Web of Science Core Collection. To identify research hotspots and future trends, countries/regions, institutions, journals, references, authors, and keywords were evaluated and visualized by Excel, VOSviewer, and CiteSpace.
Results
From 1959 to 2022, 7139 original articles were collected. The annual publications showed an increasing trend, especially after 2011. Mainland China had the most publications (n = 3719, 52.09%). Sun Yat-sen University has the most publications and citations among institutions. Jun Ma is most productive and SR Baker has the highest co-cited centrality. International Journal of Radiation Oncology-Biology-Physics is the core journal, with most publications, citations and co-citations. Analysis of keywords showed intensity-modulated radiotherapy and chemoradiotherapy were the main keywords, and multicenter was strongest burst.
Conclusion
NPC radiotherapy has attracted increasing attention, and precision and intelligence may be the future trends in this field.
Soft-balanced CAN clustering method
Authors: Xiao Zhangshu , Guo Qinyao , Liu Shigang , Wang Yuyan , Zhou Mingquan , Peng Yali , Zhao Lugang
Published: March 2023

As one of the most outstanding clustering methods, CAN can obtain accurate clustering results by imposing rank constraint to the Laplacian matrix. However, CAN ignores the balanced distribution of real-world sample data. To overcome the disadvantage, we propose a clustering method, referred to as Soft-balanced CAN clustering method (SBCAN) in this paper by introducing a soft-balanced clustering regularizer. Since our proposed method can perform two steps simultaneously with soft-balanced constraint: similarity measurement and data clustering, it can obtain the optimal clustering result. The experiments on six real-world benchmarks demonstrate that our proposed method has superior performance than the state of the art.
Coarctation of Aorta Computational Fluid Dynamics Analysis after Three-Dimensional Reconstruction and Clinical Application
Authors: Ou YangDa , Pan Bo , Lv Tiewei , Liu Lifei , Qin Jin jie , Jin Xin , Tian Jie
Published: March 2023

Objective: To investigate the clinical significance of Computational Fluid analysis in diagnosing and treating coarctation of aorta after three-dimensional reconstruction of CTA.
Methods: The clinical data and imaging data of 40 children with coarctation of aorta and 24 normal children were retrospectively analyzed and summarized, and combined with statistical means and computational fluid dynamics and explored the potential of clinical application.
Results: (1) Computational fluid pressure difference and color Doppler pressure difference analysis were performed in 40 children with coarctation of aortic arch and 24 normal children.There was no significant difference (P > 0.05) in fluid pressure between the 40 patients with coarctation group was 63.1 ± 5.1 mmHg compared with its preoperative color ultrasound pressure difference (64.1 ± 5.2 mmHg), whereas there was a significant difference (P <0.01 ) in fluid pressure between the 40 patients with coarctation of aorta and 24 patients with normal aortic arch was (4.4 ± 1.0) mmHg ;(2) After three-dimensional reconstruction, computational fluid dynamics analysis was performed to analyze the changes in pressure gradient along the aortic path, mainly in the constricted segment, and in-depth discussion and analysis were conducted. The measured pressure drop at the largest constricted segment in the constricted group was greater than 35 mmhg, while the corresponding pressure drop in the normal group children was less than 10 mmhg. The fluid vector graph showed a sharp decrease in pressure in the constricted segment, which was significantly different from the normal group.
Conclusion: Computational fluid dynamics for the diagnosis and treatment of coarctation of aorta is consistent with clinical imaging analysis methods; As a new tool for the diagnosis of coarctation of aorta , Computational fluid dynamics has the same clinical benefits, but also has many advantages that imaging does not have. Its application range is broader. Although the current sample size is not sufficient to develop new diagnostic standards, three-dimensional reconstruction of fluid dynamics analysis can provide a lower cost, less patient pressure, less uncertainty, and more accurate and intuitive assessment of the overall pressure change process of the aortic arch, It has a more comprehensive and systematic guiding significance for the diagnosis and treatment of children with coarctation of aorta.
Application of Laparoscopic Repair for Neonatal Esophageal Neonatal Hiatal Hernia
Authors: Wei Yan-Dong , Feng Zhong , Ma Li-Shuang , Wang Ying , Feng Cui-Zhu , Liu Chao , Zhang Yan-Xia , Li Jing-Na
Published: March 2023

Introduction: With the improvement of prenatal ultrasound, MR and other examination techniques, more and more hiatal hernia has been diagnosed in the neonatal period. At present, surgical indications and surgical opportunities of patients with hiatal hernia are still controversial. Through analyzing the clinical data for 11 neonates with esophageal hiatal hernia diagnosed prenatally and treated with laparoscopic hiatal hernia repair in Affiliated Children’s Hospital, this paper analyzed the laparoscopic surgical treatment and postoperative recovery of these 11 cases, explored the clinical efficacy of laparoscopic esophageal hernia repair for the esophageal hiatal hernia by ultrasonographic diagnosed prenatally, and provided clinical basis for the safety of laparoscopic surgery for prenatal diagnosed hiatal hernia in the neonatal period.
Methods: This paper retrospectively analyzed the clinical data for 11 neonates (7 males and 4 females) with esophageal hiatal hernia diagnosed prenatally and treated with laparoscopic hiatal hernia repair in Affiliated Children’s Hospital of Capital Institute of Pediatrics from May 2015 to January 2022. The age at operation was 2-94 days old, with a median of 4 days old. The body weight was (2.82 ± 0.51) kg. Preoperative chest CT and upper gastrointestinal radiography were performed to confirm the diagnosis of esophageal hiatal hernia. All the 11 children underwent laparoscopic four-hole repair of esophageal hiatal hernia and fundoplication, including 9 cases of Nissen procedure and 2 cases of Thal procedure.
Results: All the 11 operations were performed under laparoscopy without conversion to laparotomy. The operation time of 9 cases of Nissen procedure was (173.0 ± 43.8) mins, and that of Thal procedure was 184 mins and 206 mins, respectively. The time to postoperative diet was (2.54 ± 1.21) days. The hospital stay was (14.09 ± 4.13) days. The 11 neonates were followed up for 7-74 months, with a median of 28 months. No postoperative recurrence of esophageal hiatal hernia occurred. There was no significant difference in height and weight between children of the same age. No obvious vomiting or choking with milk was found.
Conclusion: Prenatal diagnosis of hiatal hernia is of great significance for identifying the types of children as soon as possible after birth, determining treatment plan, and preventing recurrent vomiting, pneumonia, growth retardation and other complications. In order to avoid gastric torsion and incarceration, laparoscopic surgery in the neonatal period is safe and reliable for the treatment of prenatal diagnosed hiatal hernia.
A Hybrid Group Acceptance Sampling plans For Life Tests Based on Gumbel Distribution
Authors: Cheepuri Chinnamamba , B.Srinivasa  , Pr.K.Rosaiah
Published: March 2023

In this research article Hybrid Group Acceptance Sampling Plans (HGASP) are developed for Gumbel distribution based on truncated lifetimes when the lifetime of a product follows a Gumbel distribution. For a given size of the group, the minimum number testers and the acceptance number of groups for the test termination time and particular consumer’s risk are calculated. Operating Characteristic (OC) function values are determined for different quality levels and the minimum ratios of the true average life to the particular life at given producer’s risk are determined. Extensive tables and examples are discussed for illustration purposes.