bluuebunny/crossref_metadata_2025 huggingface dataset:
Discurso polêmico em torno da lei da gorjeta
Authors: Sanzovo Claudia Cristina
Published: June 2023

O presente artigo situa-se no campo da argumentação do discurso e tem como objetivo descrever a forma de construção do discurso polêmico em torno da temática da lei da gorjeta através da análise dos comentários presentes no site www.jus.com.br e no grupo privado “vagas arrombadas” no facebook. Para tanto, o embasamento teórico considera a lei da gorjeta (BRASIL, 2017; SANTOS, 2017), os conceitos de comentários online em Paveau (2021) e a argumentação do discurso na modalidade polêmica em Amossy (2017; 2018). Assim, destacamos que, a partir de uma pergunta do enunciador (@) aos interlocutores (seguidores do grupo/site) cria-se uma rede de interações (comentários) que prolongam o texto primeiro através de diversas vozes plurais e contraditórias que por meio do dissenso (polêmica) contribuem para gerar um debate mais amplo sobre questões como a legalidade da cobrança das gorjetas e as relações trabalhistas entre empregados e empregadores.
Discurso, poder e subjetividade na sociedade do cansaço: um estudo de tiras cômicas da série Viver dói, de Fabiane Langona
Authors: Moura Thâmara Soares de , Brunet Patrícia Diógenes de Melo , Silva Francisco Vieira da
Published: June 2023

O estudo se propõe a analisar os discursos que circulam em tiras cômicas da série Viver dói, de Fabiane Langona, visando compreender o funcionamento das relações de poder e a construção da subjetividade na crítica empreendida acerca da sociedade do cansaço. Para tanto, toma como aporte investigativo as reflexões de Han (2015) acerca da sociedade do cansaço, os apontamentos de Foucault (1995; 2010) a respeito do enunciado, do discurso e do sujeito e as discussões de Ramos (2011) e Possenti (2010) sobre o gênero tira cômica e o humor como sob um prisma discursivo, respectivamente. As tiras discursivizam subjetividades angustiadas, as quais são forjadas no âmbito de relações de poder inscritas no sistema neoliberal.
Engenharia Civil: contribuições conceituais - Volume 2
Authors: Rêgo Fabiana Aquino de Moraes , Nunes Mirian Nunes de Carvalho
Published: June 2023

Este livro reúne informações acerca de vários temas relacionados a Engenharia Civil, tais como: estrutura, resistência de materiais, estradas, edificação, manutenção, orçamento, segurança do trabalho, resíduos sólidos, gestão de obra, recursos humanos, dentre outros. A obra é uma fonte de informação aos interessados sobre o assunto que desejam ampliar seus conhecimentos e compreender a relevância da área para a sociedade.
Haemodynamic, Biochemical and Respiratory Implications of total Bronchoalveolar Lavage in Pulmonary Alveolar Proteinosis
Authors: María Nieves Balaguer Cartagena , Ester Villareal Tello , Begoña Balerdi Pérez , Andrés Briones Gómez , Raquel Martínez Tomás , Enrique Cases Viedma
Published: June 2023

Introduction: Total bronchoalveolar lavage (BAL) continues to be the treatment of choice for alveolar proteinosis (AP), facilitating the removal of lipoprotein material. The purpose of this article is to evaluate the impact of haemodynamic, biochemical, and respiratory parameters, as well as the complications and evolution of patients undergoing this procedure. Methods: Retrospective, observational, and descriptive study of BAL. The technique was performed in the Intensive Care Unit. Blood gases, blood pressure, central venous pressure, body temperature, and fluid balance were analyzed. Results: Including eight patients, thirty-eight BAL were performed from 2008 to 2021. The mean instillation of saline at each session was 13.464 ± 4.002 ml per lung. No significant changes were observed before and after BAL in heart rate and blood pressure. Mean central venous pressure increased by 2.59 cm H20. The pO2 initial was 126 mmHg with a final mean of 69.7 mmHg, with statistical significance. The pCO2, HCO3 and pH parameters remained stable. Complications were observed during fifteen of the thirty-eight BAL (nine with arterial hypotension, three with glottic oedema, one acute pulmonary oedema, one pneumothorax, and one cardiorespiratory arrest). In terms of evolution, one case had a clinical-radiological resolution, one case of exits, one required lung transplantation, and the remaining five remained stable. Conclusion: This study demonstrates that the procedure, is well tolerated haemodynamically and that the biochemical alterations to which the patient is subjected are not compromised. With few complications and good results in delaying the progression of AP.
Gastronomi Turizmi Açısından Coğrafi İşaretli Ürünlerin Algılanma Düzeyi: Antalya Örneği
Authors: ARSLAN Filiz
Published: June 2023

Turizmin sürdürülebilirliği yönünde gastronomi turizmi oldukça önem taşımaktadır. Coğrafi işaretli ürünlerin gastronomi turizminde kullanılması turizm ürününü farklılaştırarak yöreye önemli bir çekim oluşturduğu, ekonomik kalkınmayı desteklediği, ürünü, tüketiciyi ve üreticiyi koruduğu belirtilmektedir. Bu çalışmanın amacı, Antalya ili coğrafi işaret alan bazı ürünlerinin gastronomi turizmi yönüyle bölge halkı tarafından nasıl algılandığını bulgulamaktır. Araştırma, Antalya ilinde yaşayan 143 katılımcı ile gerçekleştirilmiştir. Elde edilen veriler anket aracılığıyla toplanmıştır. Gerçekleştirilen alan araştırması sonucunda katılımcılar Antalya ilinde coğrafi işaret alan ürünlerin gastronomi turizmine katkısını ölçen sorulara olumlu yönde cevap verdiği gözlenmiştir. Katılımcıların %40,8’i Finike Portakalı’nın bölgedeki gastronomi turizminin gelişimine en fazla katkı sağlayacağını düşünmektedir.
Turizm ve Seyahat Hizmetleri Programında Görevli Akademisyenlerin Eğitim Profili: Türkiye’deki Üniversiteler Örneği
Authors: KILIÇ Ahmet Gökhan , GENÇER Kansu
Published: June 2023

Bu çalışmanın amacı, devlet ve vakıf üniversitelerinde turizm ve seyahat hizmetleri ön lisans programında çalışan akademisyenlerin eğitim profillerinin incelenmesidir. Çalışmanın evreni Türkiye’de devlet ve vakıf üniversitelerinin turizm ve seyahat hizmetleri ön lisans programında çalışan akademisyenlerin tümünü kapsamaktadır. Çalışmada veri toplama tekniği olarak nitel araştırma yöntemlerinden betimsel tarama kullanılmıştır. Çalışmanın verileri YÖK Akademik web sitesi ve ilgili üniversitelerin web sitelerinden elde edilmiştir. Toplanan verilere göre 34 meslek yüksekokulunda görevli 108 akademisyen olduğu tespit edilmiştir. Bu akademisyenlerin yaklaşık %60’ının öğretim görevlisi olduğu tespit edilmiştir. Akademisyenlerin eğitim aldıkları alanlar incelendiğinde, 63’ünün lisans, 56’sının yüksek lisans ve 39’unun doktora eğitiminin turizm alanından olduğu gözlenmiştir. Lisans, yüksek lisans ve doktora eğitimlerinde Turizm alanından sonra en çok eğitim alınan alanın işletme olduğu görülmüştür. Turizm ve işletme dışında ise lisans düzeyinde 21, yüksek lisans düzeyinde 19 ve doktora düzeyinde 16 farklı bölümün olduğu bulgularına ulaşılmıştır.
Американская финансовая система: банки просят денег
Authors: Алексеев А.В. , Дементьев Н.П.
Published: June 2023

В статье анализируются причины и особенности почтиодновременного банкротства четырех по-своему знаковых американских банков. Если три первых банка специализировались на обслуживании клиентов из весьма специфических сегментов финансового рынка (криптобиржи, венчурный капитал), то четвертый – традиционный американский банк. Показывается, что триггером для банкротства рассматриваемых банков послужило резкое повышение ключевой ставки ФРС. Однако истинная причина этих банкротств – мягкая монетарная политика, которую проводил финансовый регулятор последние полтора десятилетия. Сверхнизкая ключевая ставка способствовала формированию недостаточно качественных активов и пассивов в американской банковской системе. Невысокое качество активов проявилось при первых же признаках ужесточения монетарной политики. В статье доказывается, что вариантов легкого решения этой проблемы у американского регулятора нет.
Кто и как управляет генерирующими активами в российской электроэнергетике
Authors: Шевелева Г.И.
Published: June 2023

В статье обсуждаются инвестиционные риски, сопутствующие изменению структуры собственности российских генерирующих компаний. Выявлены существенные различия в качестве их корпоративных практик (2020–2021 гг.) с позиций Кодекса корпоративного управления Банка России. Определены наименее соблюдаемые критерии в разделе «совет директоров» Кодекса. Показаны назревшие изменения в советах директоров этих компаний при сравнении их с аналогичными органами в компаниях Германии и Франции, близких по концентрации собственности и присутствию в ней государства. Эти данные позволили обозначить необходимые преобразования советов директоров в интересах инвесторов, главным образом, в области обновления их структурных характеристик.
Surgical Reconstruction of Mitral-Tricuspid Insufficiency Combined with Biatriomegaly in Marfan Syndrome
Authors: Popov Volodymyr V. , Bolshak Oleksandr O. , Boukarim Valery Zh. , Khoroshkovata Olena V. , Gurtovenko Oleksii M. , Novikov Evgen V.
Published: June 2023

The aim. To analyze the results of introduction of complex reconstruction of the left and right parts of the heart in Marfan syndrome combined with mitral-tricuspid insufficiency, biatriomegaly and left ventriculomegaly.

Materials and methods. As an example of this pathology, we present our observation. Female patient T., 24 years old, was examined and treated from 7/27/2022 to 8/17/2022 at the Department of Surgical Treatment of Acquired Heart Diseases of the National Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine with a diagnosis: Marfan syndrome. Stage IV mitral-tricuspid insufficiency. Biatriomegaly. High pulmonary hypertension. Permanent form of atrial fibrillation (for 10 years, since 2011). IIB heart failure with left ventriculomegaly with reduced left ventricular ejection fraction. NYHA functional class IV+. The patient underwent surgery in the following volume: mitral valve replacement with full preservation of the valve apparatus + tricuspid valve plasty with the imposition of a support ring + triangular plasty of the left atrium with its partial resection + resection of the right atrium.

Results. Within 4 months after surgery, echocardiographic parameters showed significant decrease in the volume of the left ventricle, the diameters of both atria. In addition, there was a significant decrease in the level of N-terminal pro-brain natriuretic peptide and manifestations of heart failure.

Conclusion. Taking into account the initial serious condition of the patient with Marfan syndrome and advanced mitral-tricuspid heart disease, left ventriculomegaly with a reduced left ventricular ejection fraction, biatriomegaly (left atrium 7.2 cm, right atrium 6.5 cm), permanent form of atrial fibrillation, complex reconstruction of the left and right parts of the heart leads to an improvement in the functional state of the myocardium.
The Impact of Hinduism and Buddhism on the Music of Indonesia
Authors: Sunarto
Published: June 2023

The incorporation of Hinduism and Buddhism in Indonesia has given a unique characteristic to the Indonesian
cultural reality. Since the Kalinga–Bali Yatra (from 320 BC to the establishment of Kalinga kingdom in Central
Java around 500 AD), that is, the yearly ancient naval expedition of sailors from Orissa (Kalinga in India) to the
Swarnadwipa Islands (Malacca, Sumatera, Java, Borneo, and Bali), the culture of Hinduism and Buddhism has
been slowly introduced and acknowledged by the people of Indonesia. The earliest interaction between
Hinduism/Buddhism and the locals could be tracked since the period of Kalinga kingdom in the central part of Java
island. The influence of Hinduism and Buddhism in Indonesian traditional culture has penetrated to the people’s
musical tradition in Java and Bali. On top of that, the story of Ramayana and Mahabharata has been adopted into
Wayang Kulit tradition in Java. Among other Hindu–Buddhist influences in Indonesia comprise Indian drama–
dance, Rasa esthetic theory, Mahayana Buddhist influence in Bedoyo, Slendro pathet (Javanese gamelan musical
organization system), and Hinayana Buddhist concept of removal of nine consciousness of human beings.
The Lived Experiences of Independent Western Classical Chamber Musicians in the United Arab Emirates: A Narrative Inquiry
Authors: Martens Mia , Wentink Catrien
Published: June 2023

The research concerns the relationship between Western classical music and Arabian cultures in the United Arab
Emirates (UAE) as experienced by independent classical chamber musicians. The main research question was:
what stories do independent Western classical chamber musicians tell about their lived experiences of practicing
and performing Western classical music in the UAE?
The real-life problem guiding this research has two parts:
i. the problem that Western classical music is not a sustainable profession for performers in the UAE and
ii. the gap in the literature on Western classical music in the UAE.
The real-life problem the first author experienced in the UAE as a Western musician had the following challenges:
practical obstacles related to sourcing fellow musicians who uphold the same standards and music ideals, finding
rehearsal venues and creating performance opportunities. These challenges lead to the formation of the research
problem.
Amy Wilkinson and the Chinese Blind Boys Band
Authors: Robinson Keith , Lingli Wang
Published: June 2023

One aspect of the work that the missionaries did in China that has received little attention is the teaching of the
blind to read, in particular to read music. Amy Wilkinson is particularly interesting because in 1922, she brought
her Chinese Blind Boys Band to England and they toured all over the country giving concerts. The concerts were
widely reported in the local press, and so we have quite detailed positive accounts of how well the band played.
Any scepticism about what the standard of performance might have been like can be quelled by reading these
accounts. What this book attempts to do is understand how these early pioneers developed systems to enable the
blind Chinese to read in Chinese, with first the use of embossed letters and then Braille. They then went on to
teach music notation with embossed systems and then later Braille music notation. There are considerable technical
difficulties for blind people to read Braille music notation, and these must have been made more challenging
teaching blind Chinese boys Western instruments and music that required an understanding of Western harmony
and rhythm. Amy Wilkinson’s achievements in this field deserve wider recognition than they have so far received.
Block Copolymers of Ethylene Oxide and Propylene Oxide: Prospects for Medical and Pharmaceutical Application in Russia
Authors: Bakhrushina E. O. , Pyzhov V. S. , Sakharova P. S. , Demina N. B. , Chizhova D. A. , Tabanskaya T. V. , Lutfullin M. F.
Published: June 2023

Block copolymers of ethylene oxide and propylene oxide (EO/PO block copolymers) are polymeric non-ionic surfactants with a high hydrophilic–lipophilic balance also referred to as pluronics, poloxamers, or proxanols. These compounds are among the most demanded modern excipients for the production of medicines. EO/PO block copolymers are used both in the production of traditional (liquid, semi-solid, and solid) dosage forms and as part of targeted delivery systems. The extensive application of EO/PO block copolymers is due to the diverse array of their properties, including not only solubilising, emulsifying, gelling, and other effects but also thermoreversibility, which is essential for developing in situ delivery systems and 3D printing technologies.

The aim of the study was to evaluate the potential of EO/PO block copolymers for medicinal use and to assess the range of medicinal products approved in the Russian Federation that contain EO/PO block copolymers.

This review presents an analysis of the register of poloxamer-containing medicines approved in the Russian Federation, a list of the largest manufacturers of EO/PO block copolymers in the world, and a study of the possibility to use copolymers for medical purposes. Currently, there are more than 10 chemical manufacturers producing EO/PO block copolymers for the pharmaceutical, biotechnology, and other industries around the world. EO/PO block copolymers are included in more than 60 medicinal products present in the Russian pharmaceutical market; this observation indicates the need to phase out the import of poloxamers.
Organisational and methodological challenges of CAR-T manufacturing in the Russian Federation
Authors: Drokov M. Y. , Gaponova T. V. , Gubenko T. Y. , Karavaeva O. S. , Telyashov M. A. , Antimonov A. S. , Zubkov V. V. , Parovichnikova E. N.
Published: June 2023

Despite their widespread clinical implementation, chimeric antigen receptor T-cell (CAR-T) therapy products, including those manufactured by industrial processes, are still not legally available or used in the Russian Federation.

The aim of the study was to describe the current challenges associated with specific aspects of CAR-T manufacturing in the Russian Federation and the potential ways to overcome them.

This article discusses the regulatory, legal, organisational, and methodological challenges of CAR-T manufacturing. It analyses differences in the interpretation of CAR-T therapy products under national and supranational law. According to Russian Federal Law No. 180-FZ “On Biomedical Cell Products” of 23 June 2016, CAR-T therapy products are considered biomedical cell products. However, according to Decision No. 78 of the Council of the Eurasian Economic Commission “On the Rules of Marketing Authorisation and Assessment of Medicinal Products for Human Use” of 3 November 2016, CAR-T therapy products are considered advanced therapy medicinal products (ATMPs). This article provides a detailed overview of the difficulties in obtaining starting biological materials (i.e. the inability to consider the patient as a donor) and transferring the materials for CAR-T manufacturing (i.e. the inapplicability of national law). In addition, this article describes export aspects specific to biological materials. The authors reckon that CAR-T therapy products should be categorised as ATMPs and that the corresponding active pharmaceutical ingredients, genetically modified autologous lymphocytes, should be defined as starting materials. Therefore, genetically modified autologous lymphocytes should be regulated under the requirements for starting materials for the manufacturing of active pharmaceutical ingredients that are set forth in Decision No. 77 of the Council of the Eurasian Economic Commission “On the Adoption of the Rules of Good Manufacturing Practice of the Eurasian Economic Union” of 3 November 2016. In conclusion, the authors recognise the need for national and supranational law harmonisation. For this task, it is necessary to establish expert groups that will include clinicians, legal experts, and representatives from the relevant authorities and the pharmaceutical industry.
Evaluation of the applicability of immunochromatography to the identification of live plague vaccines and the tularaemia allergen (Tularin)
Authors: Kasina I. V. , Alekseeva S. A. , Nemirovskaya T. I.
Published: June 2023

The regulatory standards require that the identification of live plague vaccines and the liquid tularaemia allergen (Tularin) should be performed by immunofluorescence. A major drawback of the recommended method is its labour intensive nature. However, immunochromatography represents an alternative method that offers a number of advantages, including rapid testing and easy result interpretation.

 The aim of the study was to assess the applicability of immunochromatography to the identification of live plague vaccines and the liquid tularaemia allergen (Tularin).

Materials and methods. The authors performed identification tests using samples of the pharmacopoeia standard for live plague vaccines, three commercial batches of a live plague vaccine, and two batches of the liquid tularaemia allergen (Tularin). These samples were tested using immunochromatographic assay (ICA) reagent kits for rapid detection and identification of Yersinia pestis (ICA System for Y. pestis) and Francisella tularensis (ICA System for F. tularensis) manufactured by the State Scientific Center for Applied Microbiology and Biotechnology.

Results. The findings show that immunochromatography is an effective, rapid, and species-specific method to confirm the presence of Y. pestis in a sample of a live plague vaccine or F. tularensis in a sample of the liquid tularaemia allergen (Tularin). To perform identification tests by immunochromatography, the authors recommend diluting live plague vaccine samples to a concentration of 109 bacterial cells/mL and using undiluted samples of the liquid tularaemia allergen (Tularin).

Conclusions. The study results may support the inclusion of ICA into the regulatory standards for live plague vaccines and the liquid tularaemia allergen (Tularin) as an alternative identification method.
MODAL ANALYSIS OF FIBER OPTIC RESONANCE PIEZOELECLUMINESCENT PRESSURE SENSOR
Authors:   Perm National Research Polytechnic University, 614990, Perm, Komsomolsky ave., 29, Pan’kov A.A. , Pisarev P.V. ,   Perm National Research Polytechnic University, 614990, Perm, Komsomolsky ave., 29, Bayandin S.R. ,   Perm National Research Polytechnic University, 614990, Perm, Komsomolsky ave., 29
Published: June 2023

An electro-mechanical mathematical model of the functioning of an optical fiber resonance piezoelectroluminescent (RPEL) sensor with an external nonlinear elastic buffer layer has been developed. The sensor is designed to measure the distribution spectrum along the length of the dynamic and/or static pressure sensor using a resonant diagnostic method based on the results of measuring the amplitude spectrum of the intensity of the resulting light flux at the output from the fiber of the sensor. The numerical values of the frequency characteristics (- these are the proportionality coefficients for the informative relationship "pressure/resonance frequency") of the optical fiber RPEL sensor, which are used in the algorithm for finding the pressure spectrum, for different (first six) modes of vibration, are determined.
Türkiye’de Küresel İklim Değişikliğiyle Mücadelede Sübvansiyon Politikalarına Yönelik Bir Tutum Araştırması
Authors: YAPICI SAPANKAYA Fatma
Published: June 2023

Günümüzde küresel düzeyde öne çıkan önemli sorunlardan biri iklim değişikliğidir. İklimlerde aşırı soğuma ve ısınma şeklinde değişiklikler yaşanırken, yağış rejimlerinde, buzul alanlarının büyüklüğünde, tarımsal üretkenlikte ve biyoçeşitlilikte olumsuzluklar yaşanmaktadır. İklim değişikliğiyle mücadelede atmosferdeki ortalama sıcaklık artışının temel sebebi olarak görülen sera gazı emisyonu konsantrasyonunun azaltılması gereklidir. Sera gazı emisyonlarına yol açan fosil kökenli enerji türlerine sağlanan sübvansiyonların azaltılması ve tasarruf edilen bu kaynakların daha çevreci enerji kaynaklarına aktarılması eğilimi vardır. Araştırmanın amacı Türkiye’de enerji sektöründe çalışan uzmanlar ile akademisyenlerin iklim değişikliği ve iklim değişikliğiyle mücadele kapsamında sübvansiyonlara olan bakış açısını araştırmaktır. Yarı yapılandırılmış mülakat yöntemiyle bir alan araştırması gerçekleştirilmiş olup enerji alanında çalışmakta olan 28 kişilik bir gruptan iklim değişikliğiyle mücadele ve enerji sübvansiyonları konusunda görüş alınmış ve içerik analizine başvurulmuştur. Dört bölümden oluşan çalışmanın ilk bölümünde iklim değişikliğiyle mücadelede sübvansiyonların önemi belirtilirken ikinci bölümde araştırma bulgularına yer verilmiştir. Çalışma sonuç ve öneriler kısmıyla sona ermektedir.
Identity of Architecture: The Case of the National Library of Kosovo
Authors: Kumaraku Llazar , Pula Dasara
Published: June 2023

This article is part of a research on concepts that belong to theoretical speculation sin the discipline of architecture. The main intention is to shed light on the relationship of these theoretical concepts with the construction of architectural form and the episteme of architecture itself. One such concept is the identity of architecture. In this context, this research aims to clarify the interplay between identity – as a theoretical concept that is directly related to the form – and the architectural discipline. The first hypothesis is that architectural forms do not have a particular identity detached from their formal essence, but have an identity expressed by morphology. Second, different architectures, being forms of representations, express an external identity depended on the historical, political, social or cultural conditions. This article defines three main plans through which the identity of an architectural work is manifested: formal, stylistic/linguistic, and technological. The followed methodological approach is based on a theoretical analysis of the concept of identity, its contextualization within the discipline of architecture, and the interpretation of the results of such analysis through the case study of the National Library of Kosovo, built in Prishtina during 1971-1982. The study of the National Library is conceived as an example where the results obtained at a theoretical level and which aim to further clarify the discourse on the presented concepts, are expected to be verified.
Virtue Ethics and Ubuntu in Leadership towards the Promotion of Ethical Organisational Operations
Authors: Nicolaides Angelo , Dludla Nkosinathi
Published: June 2023

The objective of the conceptual literature study is to assess virtue ethics as a viable ethical leadership theory in African countries, more explicitly South Africa. We pinpoint some deficits in ethical leadership, which could be addressed through adopting a virtue ethics driven ethical organisational climate in order to positively enhance business practices and service to the community and society in general. This paper supports the notion of virtue ethics as being the suitable one for the purpose of motivating an ethical climate which leads to sustainable business. Leaders need to assume core responsibility for promoting ethics and should reinforce the notion of morally correct behaviour at all times through their demonstrable ethical conduct. This necessitates that leaders’ must exhibit virtue and possess particular qualities and know how to apply these to workplace situations. Virtue ethics as one of numerous ethical theories, certainly has a role to play in the contemporary discourse in which corruption is rife. In addition, it aligns in many ways with the notion of Ubuntu. We argue that ethical leadership behaviour based on virtue and an Ubuntu spirit, is critical in supporting an ethical climate in any organisation and it promotes sustainability. The study employed an interpretivistic expository methodology of textual analysis based on extant literature. Thus, it is to an extent hermeneutic in nature and leads to insights supporting the notion of using Virtue ethics and Ubuntu to inform practice in African organisations and society. Keywords: virtue ethics, Africa, organisations, Ubuntu, sustainability
Asymmetric Effect of External Debt and Foreign Capital Flows on Economic Growth: New Evidence from Nigeria
Authors: Udeaja Elias A. , Audu Nathan
Published: June 2023

This research examines the asymmetric nexus between external debt and foreign capital flows on economic growth in Nigeria. The paper employed the non-linear autoregressive distributed lag (NARDL) methodology to investigate the asymmetrical effect of external debt on real Gross Domestic Product (GDP) growth in Nigeria. The estimated long-run parameters for positive and negative shocks of external debt are -1.08 and 3.09, respectively. The outcome indicated that a percentage increase in external debt will result in a 1.08 decrease in real GDP growth and that a one percent decrease in external debt will result in a 3.08 increase in economic growth. This illustrates that the receptiveness of real GDP growth to positive values of external debt is different to that of negative values of external debt. The reaction of real GDP growth to negative values of external debt is larger than to positive value of external debt. This suggests that it is imperative for Nigeria to have manageable external debt and fiscal sustainability as this would bolster its real economic growth as well as urge the fiscal authority to make concerted effort towards curbing corruption and reducing inefficiency to the barest minimum, as these will enhance growth. Keywords: Nigeria, external debt, economic growth, asymmetry, foreign capital inflows JEL Classification: C22, E62, F43, O11
Corporate Digital Responsibility in the Retail Industry: Cameo Case Studies of Two German Retailers
Authors: Jones Peter
Published: June 2023

Digital technologies bring a wide range of new opportunities, for both retailers and consumers, but retailers face, and may have to address, several new sets of responsibility issues as they progressively introduce these technologies. These responsibilities are increasingly being captured in the concept of corporate digital responsibility (CDR) but CDR within the retail industry has received little, or no attention, in the academic literature. This paper looks to make a small contribution to addressing that gap in the literature. The paper includes some definitions of CDR, an outline of the concept and scope of CDR, two cameo case studies which provide a simple illustration of some of the ways in which the Rewe Group and the Otto Group, two of Germany’s leading retailers, choose to publicly address CDR, and offers some reflections on retailers and CDR. The paper suggests that there are, potential tensions between the retailers’ management of the economic and the social dimensions of CDR, and that there are issues about whose best interests are served by CDR and the difficulties involved in making such judgements. Keywords: corporate digital responsibility, retailing, digital technologies, case studies, Germany
Avaliação do perfil das intervenções realizadas pelo farmacêutico clínico e multidisciplinares após a implantação da metodologia FASTHUG em uma unidade de terapia intensiva
Authors: SOUZA Alex Junior , BANHUK Fernanda Weyand , ALMEIDA Andressa , GROLL Simone Von , SANCHES Andreia Cristina , CALDEIRA Luciane Fátima
Published: June 2023

Objetivo: Avaliar o perfil das intervenções farmacêuticas e multidisciplinares após implantação do mnemônico FASTHUG em reunião multidisciplinar de uma unidade de terapia intensiva adulta e a presença de um farmacêutico clínico nesta equipe. Métodos: Estudo transversal, onde foram acompanhados 225 pacientes, por meio da análise dos dados demográficos e clínicos a partir de prontuário eletrônico disponibilizados pelo serviço de farmácia clínica do Hospital Universitário do Oeste do Paraná e avaliação das intervenções realizadas através dos indicadores de acompanhamento. As intervenções multidisciplinares e farmacêuticas foram registradas durante as reuniões multidisciplinares e classificadas de acordo com o mnemônico FASTHUG, que abrange aspectos como alimentação, analgesia, sedação, profilaxia de tromboembolismo, cabeceira elevada, profilaxia de úlcera de estresse e controle glicêmico. Resultados: Foram realizadas 1078 intervenções, com uma média de 4,79 intervenções por paciente acompanhado. As intervenções multidisciplinares mais frequentes foram acréscimo de medicamento necessário 248 (27,2%), otimização de dieta 145 (15,9%), otimização de analgesia 128 (14%), otimização do controle glicêmico 109 (12%), otimização da frequência de administração e suspensão de medicamento não necessário, ambos 68 (7,5%). Já as intervenções farmacêuticas mais comuns foram otimização da frequência de administração 40 (24,3%), acréscimo de medicamento necessário 18 (11%), suspensão de medicamento não necessário 17 (10,3%) e alteração de redução de dose 15 (9,1%). Em relação aos desfechos dos pacientes, 75,1% receberam alta para a enfermaria, 24,4% foram a óbito e 0,4% foram transferidos para outro hospital. Conclusão: A implantação do mnemônico FASTHUG em uma unidade de terapia intensiva proporcionou uma padronização na linguagem entre a equipe multidisciplinar durante as reuniões clínicas, bem como, possibilitou a avaliação de pontos essenciais a farmacoterapia pelo farmacêutico clínico.
Effect of the nutrition violation on the of development of functional gastrointestinal disorders in school-age children
Authors: Belousova O. Y. , Zimnytska T. V. , Kazaryan L. V.
Published: June 2023

Nutrition is one of the important risk factors for the occurrence of functional gastrointestinal disorders in children (FGID).
Objective — to study the nutrition violations in children with FGID.
Materials and methods. Observation involved 110 children with FGID aged 6 to 18 years. The patients were divided into two groups:  I study group included 44 children with an overlap of functions dyspepsia (FD) and irritable bowel syndrome (IBS). The II study group consisted of 66 pediatric patients with FD. The control group consisted of 30 healthy children. The diagnosis of functional dyspepsia and IBS was established based on the clinical symptoms according to the Rome IV criteria (2016). To detect violations in the nutritional regimen and food preferences of schoolchildren, a questionnaire survey was performed with the use of the Youth Adolescent Food Frequency Questionnaire, adapted to the model of children’s nutrition in Ukraine.
Results. The frequency of violations in the nutritional regimen, such as refusal of breakfast or a full lunch at school, reducing the daily frequency of meals, was higher in children with FGID than in healthy children. The violations of nutrition in children with overlapping FD and IBS was observed more often than in children with FD. The frequency of consumption of vegetables, cereals and grains was lower in children with FGID, and the consumption of meat, sausages and confectionery, fast food, chips, nuts and seeds, energetics and sweet carbonated beverages was higher than in healthy children. In children with overlapping FD and IBS, the frequency of consumption of vegetables, cereals and grains is lower, and the consumption of confectionery, fast food, energetics, and sweet carbonated drinks was higher than in children with FD.
Conclusions. Violations of the regimen and quality of nutrition is a risk factor for the formation of FGIR in children and should be considered in the treatment.
Psychogastroenterology of disorders of intestinal-brain interaction. Review with own research
Authors: Gubska O. Y. , Prykashchykova H. I.
Published: June 2023

Disorders of the gut‑brain interaction (DGBI), previously known as functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), functional dyspepsia (FD), and functional constipation (FC), are widespread worldwide (affecting 40% of the population in different periods of life). Modern understanding of pathophysiology of these conditions are determined by the bidirectional interaction between the intestine and the brain, represented by the biopsychosocial model, as well as changes in the intestinal microbiota, immune function of the mucous membrane, visceral hypersensitivity and abnormal motility of the gastrointestinal tract. Early detection, using symptom‑based criteria, and treatment of these disorders is crucial, as they significantly affect a patient’s quality of life and work capacity, creating a heavy burden on the health care system and entire society. Unfortunately, despite the available recommendations, consensus and a wide range of pharmacotherapeutic approaches, the problem of DGBI remains unresolved. The widespread reasons for the lack of effectiveness DGBIs treatment include stigmatization, late diagnosis and postponing the prescription of therapies affecting the gut‑brain axis, including delay in prescribing neuromodulators and the use of psychological treatment methods. The diagnosis of DGBI is based on the Rome IV criteria and should no longer be considered as a diagnosis of exclusion. Treatment approaches should be more personalized and based not only on symptoms, but also on underlying pathophysiological and psychological features. The purpose of this review is to inform clinicians about the main psychological approaches to the treatment of disorders of the gut‑brain interaction, which should be considered as a comprehensive treatment of DGBI. The purpose of this article is to inform clinicians about main psychological methods of psychotherapy (psycho‑correction) of gut‑brain‑interaction‑disorders, which should be considered as a comprehensive treatment of DGBI, among which biosuggestive therapy has already taken a special place.
Bacterial overgrowth in irritable bowel syndrome: prevalence, diagnosis, and treatment. Review
Authors: Tkach S. M. , Dogotar V. B.
Published: June 2023

To date, irritable bowel syndrome (IBS) is considered as a multifactorial syndrome with the involvement of several central and peripheral pathogenic mechanisms. One of the main peripheral risk factors for IBS is the syndrome of intestinal bacterial overgrowth (SIBO). Only few studies, investigating SIBO frequency in patients with IBS, have been conducted, their nature is often incomplete and contradictory, and doesn’t consider clinical features and severity of SIBO course. The effectiveness of SIBO eradication in modifying of IBS course is unclear. The article presents an overview of current data on the prevalence of SIBO in IBS compared to controls when using various diagnostic methods, as well as the impact of SIBO eradication on the course of IBS. It is emphasized that the latest systematic reviews and meta‑analyses show that SIBO is closely related to IBS, especially IBS with diarrhea, and the prevalence of SIBO at IBS has been increasing in recent years. In addition, a positive relationship between IBS with constipation and methane‑positive SIBO is determined. The use of the H2‑lactulose breath test is the main practical method of diagnosing SIBO, although it gives significantly higher rates of its prevalence both in patients with IBS and in the corresponding healthy controls. Unfortunately, the sensitivity and specificity of SIBO diagnosis using breathing tests is limited, and the results of studies reflect significant «clinical heterogeneity» due to the lack of uniform criteria for the selection of patients and individuals of the control group. Thus, diagnostic results using hydrogen breath tests should be interpreted with caution. In view of the limitations of available diagnostic tests, there is a need to develop and validate methods to better reveal the presence of SIBO in patients with IBS and ideally guide therapy. In any case, confirmation of the presence of SIBO in patients with IBS requires the administration of antibiotics, rifaximin‑α is the most effective and safe. The clinical improvement and reduction in the frequency of relapses after eradication of SIBO indicates that the latter may play a pathogenetic role in IBS.
Current issues of therapy in the scientific heritage of Academician Lyubov Trokhymivna Mala and her school (to the 20th anniversary of the death of L. T. Mala)
Authors: Fadieienko G. D. , Miloslavsky D. K. , Gridasova L. M. , Kuleshova O. M.
Published: June 2023

The review, dedicated to the 20th anniversary of the death of Academician Lyubov Trokhymivna Mala, provides data on her scientific, medical and pedagogical activities, focuses on the interests of this outstanding personality in the leading issues of internal medicine, including acute myocardial infarction, endothelial dysfunction, atherogenesis, heart failure, arterial hypertension, issues of gastroenterology, nephrology, pulmonology, pharmacotherapy. The authors highlight the achievements of students and followers of Academician Mala in the investigation of basic internal diseases from the standpoint of their comorbidity, and present information on the development of effective approaches to the diagnosis, treatment and prevention of leading therapeutic pathologies by the scientists of the Institute of Therapy.
Efficacy of inclusion of vitamin U and provitamin B5 combination in the complex therapy of primary osteoarthritis against the background of gastrogenic exocrine pancreatic insufficiency
Authors: Halabitska I. M. , Babinets L. S.
Published: June 2023

Clinical comorbidities at osteoarthritis (OA) complicate its treatment. The number and nature of various comorbid conditions determine the severity of the condition in patients with multimorbidity. However, apart from the common risk factors such as aging and obesity, little is known about the biological plausibility of explaining the co‑occurrence of OA and comorbidities. According to the European Alliance of Associations for Rheumatology, EULAR, and the National Institute of Health and Nursing, the diagnosis and treatment of specific comorbidities, as well as understanding their nature in OA, are important for choosing the best treatment tactics.
Objective — to investigate efficacy of inclusion of vitamin U and provitamin B5 combination in the complex therapy of patients with primary OA in comorbidity with gastrogenic exocrine pancreatic insufficiency (EPI) for the correction of clinical syndromes.
Materials and methods. Examinations involved 61 patients with primary OA in comorbidity with gastrointestinal diseases, accompanied by EPI of gastrogenic genesis without exacerbation. The comparison group consisted of 30 practically healthy people. All patients were divided into two comparable groups: group 1 (n=30) received a course of basic therapy drugs, namely: nonsteroidal anti‑inflammatory drugs, chondroprotectors and/or chondrostimulators, antispasmodics, prokinetics, proton pump inhibitors, enzyme agents (pancreatin); group 2 (n=31), in addition to the course of basic therapy, received a course of the vitamin drug combination of vitamin U and provitamin B5, 2 tablets once a day for 6 weeks. The calculation of the WOMAC index (Western Ontario and McMaster University) was used to assess the articular status of patients with primary OA, as well as the effectiveness of the treatment measures. Gastrointestinal Symptom Rating Scale (GSRS) questionnaire was used to assess gastrointestinal symptoms.
Results. The proposed complex treatment of patients with primary OA with gastrogenic EPI with the additional inclusion of a vitamin preparation combination of vitamin U and provitamin B5 contributed to more significant regression of WOMAC indices compared to that during protocol treatment (the total WOMAC index decreased by 16.03% against 9.10%, respectively) and indicators of the scales of the GSRS questionnaire in comparison with the subgroup that received treatment according to the protocol (in total — by 35.96% vs. 22.19%, p <0.05),
Conclusions. The study results showed the advisability of using a vitamin medication, a combination of vitamin U and provitamin B5. in the treatment of patients with primary OA with gastrogenic EPI.
Nonalbuminuric diabetic kidney disease: what is known? Literature review
Authors: Chernyshov V. A.
Published: June 2023

Urinal albumin excretion is widely used in clinical practice as an indicator of diabetic renal injury. In accordance with a classical conception of diabetic nephropathy clinical course, an albuminuria usually precedes a reduction of renal function.
The review is devoted to discussion of an actual problem of contemporary nephrology, nonalbuminuric diabetic kidney disease (NADKD), its prevalence increasingly grows in population of patients with type 2 diabetes mellitus due to efficacy of glucose lowering, hypotensive, hypolipidemic therapy and smoking cessation. NADKD is more frequently revealed among females; it is associated with arterial hypertension and ischemic heart disease. Renal changes in patients with NADKD are heterogenous compared with albuminuric diabetic patients and interstitial changes as well as atherosclerosis can turn out to be the main morphological finding in the absence of glomerulopathy signs. Some modern pathophysiological mechanisms proposed today for understanding of NADKD such as vascular, inflammatory, acute renal injury and use of pharmacological agents with renoprotective properties are elucidated. Contemporary data about clinical characteristics of NADKD, as well as its prognostic value, diagnostics and monitoring and its association with cardiovascular risk are given. A prognostic significance of NADKD should be defined more precisely. NADKD is shown to increase a risk of myocardial infarction and stroke development as well as a death from cardiovascular causes in patients with diabetes mellitus. An importance of the search for alternative diagnostic markers for detecting renal injury in the absence of albuminuria is emphasized. The evaluations of the markers of tubular damage and interstitial fibrosis, as well as proteomic approaches, are considered today as perspective diagnostic and prognostic options in NADKD. The study of pathogenesis, pathomorphology, clinical course of NADKD, as well as the development of approaches for an early diagnostics and treatment of this complication of diabetes mellitus are determined as the tasks for future research.
Using Grey-TOPSIS approach for solar farm location selection in Libya
Authors:   Libyan Academy- Misurata, Libya, Badi Ibrahim , Abdulshahed Ali ,   Misurata University, Libya, Alghazel Emhemed ,   Libyan Academy- Misurata, Libya
Published: June 2023

The utilisation of renewable energies has emerged as a pressing environmental imperative, particularly in view of the elevated levels of pollution and amplified global warming resulting from the consumption of vast quantities of fossil fuels for energy generation. The field of research has contributed to the reduction of expenses associated with the acquisition of renewable energy, thereby positioning it as a formidable contender against conventional energy sources. Although several developed nations have made significant progress in integrating renewable energy sources into their energy portfolio, developing countries still face challenges in this regard, despite the accessibility of such energy sources. The present investigation employed a hybrid multi-criteria approach that integrates the GREY-TOPSIS method to identify the optimal location for the establishment of a solar farm. A total of twelve criteria were utilised to evaluate and contrast the suggested locations. The GREY method was employed for the purpose of extracting criteria weights. A comparative analysis was conducted on six potential locations within the Libyan territory, considering a set of twelve established criteria. It is noteworthy that Libya's energy generation is predominantly reliant on non-renewable sources. According to the findings, the criteria of average solar radiation and sunshine hours hold the highest significance with a weightage of 0.9. As per the model, Misrata emerged as the highest-ranking city with a weightage of 0.53, while Benghazi, situated in the western region of the country, secured the second position with a value of 0.47. The methodology and evaluation criteria utilised in this study have the potential to be implemented in other urban areas, thereby facilitating the pursuit of sustainable development.
ANALISIS MEDIA BERBASIS VIDEO TERHADAP PENINGKATAN MOTIVASI BELAJAR SISWA DALAM PEMBELAJARAN DI SEKOLAH DASAR
Authors: Agistia Helda
Published: June 2023

Terkait Analisi Media Berbasis Video Terhadap Peningkatan Motivasi Belajar Siswa dalam Pembelajaran di Sekolah Dasar