bluuebunny/crossref_metadata_2025 huggingface dataset:
Monitoring Line Efficiency in Garment Industry using IoT
Authors: Alex Shelcy S
Published: February 2022

Abstract: The conventional method of monitoring efficiency in garment industry is to collect the number of pieces produced per hour by each line manually and entered in the website . This method is time consuming, wastage of man power, and involves non valued activities. The IOT based line efficiency monitoring system that checks the efficiency of end line production in garment industry in real time through weight sensor (one for each parameter: pass pieces, defect pieces) . Weight of the garment and the target per hour are given as the input. As a variation in the value of weight sensor signifies that garment is dropped into the bin, therefore the number of pieces produced is increased and vice versa. The Wi-Fi module in the system transfers data processed by the microcontroller, and transfers the data to the website as well as smart phone. This system can help the factory officials to monitor efficiency at real time basis. Keywords: IoT, Weight sensor, Node MCU, real time efficiency monitoring.
Analysis of Effects of Covid-19 on the Attendance of Children and its Outcomes of Their Treatment in a CTEV Clinic of West Delhi
Authors: Arora Vineet Kumar
Published: February 2022

Abstract: Treatment of Clubfoot children by Ponseti method of serial casting is a well know procedure being practiced all over the world. During Covid times many children were not able to attend their regular CTEV clinics at various places leading to inadequate treatment of this deformity. This not only causes relapses but may also lead to the permanent disability. The fear of permanent disability of these children motivated us to create awareness among the parents regarding this and hence bringing them back to CTEV clinics on regular basis. Keywords: Clubfoot children, CTEV Clinics, Ponseti method, Relapses, Permanent disability
PERCEPÇÃO DE QUALIDADE EM SERVIÇOS DE ENSINO SUPERIOR
Authors: Siqueira Luciano Oliveira , Filho Luiz Fernando Fritz
Published: February 2022

Objetivo: A expansão do ensino superior no Brasil observado nas últimas duas décadas acirrou a competição entre as Instituições de Ensino Superior (IES) e se apresenta como um grande desafio para gestores destas instituições. O objetivo deste estudo foi desenvolver uma ferramenta de marketing para analisar a satisfação de serviços prestados em IES mediante unificação das ferramentas SERVQUAL, SERVPREF, ECSI e questionário do ENADE.
Método / abordagem: Aplicou-se um questionário constituído de 51 constructos divididos em 7 dimensões (aspectos acadêmicos, empatia, aspectos curriculares, confiança, imagem, lealdade, satisfação e infraestrutura) a 373 alunos de uma unidade acadêmica constituída de 7 cursos.
Principais resultados: A análise dos resultados mostra uma forte correlação entre o conceito do ENADE e aspectos acadêmicos; indiretamente os aspectos curriculares, satisfação e lealdade. Por outro lado, imagem, empatia, confiança e infraestrutura, mostram uma forte correlação intergrupo.
Contribuições metodológicas / sociais / gerenciais: os aspectos curriculares, seguido de aspectos acadêmicos são as dimensões que mais impactam na satisfação do aluno de ensino superior.
Originalidade / relevância: O presente estudo inova em integrar diferentes ferramentas de marketing de forma aplicada ao ensino de nível superior.
Innovations in agro-industrial production as a driver of increasing the resilience of national food systems
Authors: Tikhomirova Vera A.
Published: February 2022

The destabilization of the world food market, as well as the frequent interruptions in the supply of agricultural raw materials and food products due to the global coronavirus pandemic, have catalyzed the growing interest of the overwhelming majority of countries in the world to ensure the highest possible level of national food security. The research is devoted to the study of the agri-food systems of Saudi Arabia, Japan and Singapore, as countries with the most progressive experience in the field of agricultural production. The author identified the production of crop products through hydroponics, meat substitutes based on vegetable proteins, laboratory-grown cultured meat, as well as alternative proteins for the fodder base of animal husbandry, poultry farming and aquaculture as the most promising scientific and technical innovations in the field of agro-industrial complex. The results of the study showed the need to adapt advanced food production technologies to the agro-industrial complex of the Russian Federation.
To the anniversary of Professor, Doctor of Geography Irina Rodionova - a woman who works to make the world a better place
Authors: Shuvalova Olga V. , Kreydenko Tatiana F.
Published: February 2022

Doctor of Geography, Professor Irina Alexandrovna Rodionova - recognized specialist in the field of industrial geography. For more than a quarter of a century she gave to work at the Lomonosov Moscow State University and about the same number - work at the Peoples Friendship University of Russia. Her life is full of events and meetings with interesting people. There were also difficulties. It was especially hard for scientific and pedagogical workers in the 1990s, when their work was poorly funded. Specialists did not remain in science, but Irina Alexandrova did not leave it. In the 1990-2000s, many students knew I.A. Rodionova from textbooks. Using them, they entered universities in geographical and economic specialties. 2021 was also a difficult year, when distance learning was introduced. Conferences were also held remotely. Irina Alexandrovna coped with these problems, successfully working both in the teaching and in the scientific field. She generously shares her knowledge and experience with colleagues and students and is the developer of a number of disciplines taught at universities. Under her leadership, 10 dissertations were successfully defended. I.A. Rodionova is the author of more than 400 publications, many of which she published in co-authorship with colleagues and students. She took part and created many textbooks for universities on the geography of industry, economic geography, and is one of the authors of the atlas for the school textbook on geography of grades 10-11. This article - a small fraction of gratitude from colleagues and students in honor of the anniversary of I.A. Rodionova.
Com o que sonha o Lula? Krenak sonha com lives
Authors: Raiz Julia , . Maré
Published: February 2022

COM O QUE SONHA O LULA? KRENAK SONHA COM LIVES não é só um texto, é uma sondagem no escuro. A bandeira nos chamou para uma DR. Sonhamos com e sem ela. Depois recolhemos o que deu das não-imagens, não-significações, não-identidades. Tudo no sonho muda como na natureza, todas as formas caminham para a indefinição. COM O QUE SONHA O LULA? KRENAK SONHA COM LIVES é registro da indefinição dos sonhos. Trabalhamos a partir do princípio de Estigmergia. Na estigmergia não existe planejamento prévio, mas um encadeamento de ações que puxam outras ações. A gente vai lá e faz para dar início a uma Ação Oportunista [Ritual Poético], dá um passo atrás pra ver o que aconteceu e depois faz de novo, dando início a outra Ação. Aqui sonhamos como gente e trabalhamos como formigas. A bandeira não disse nada porque a bandeira não existe.
User Experience dan Antarmuka Pengguna Berbasis Audio pada Aplikasi Blindness Guidance
Authors: Cai Hong Liang , Hareva David H , Lazarusli Irene A
Published: February 2022

Aplikasi blindness guidance merupakan sebuah sistem yang dirancang untuk membantu orang- orang tunanetra agar dapat mencapai lokasi tujuan dengan aman. Sejauh ini, orang-orang tunanetra tidak dapat menggunakan sistem untuk bernavigasi seperti Google Maps karena sistem-sistem tersebut tidak mengintegrasikan fitur-fitur esensial seperti tampilan pengguna (User Interface) yang sesuai dengan keterbatasan pengguna untuk dapat memberikan peringatan dan informasi yang dapat membuat pengguna menjadi lebih aman. Tampilan pengguna atau User Interface yang dibuat akan dilengkapi dengan fitur text-to-speech maupun speech-to-text sehingga pengguna tunanetra dapat melakukan komunikasi langsung tanpa kesulitan yang disebabkan karena keterbatasannya. Platform Google Maps akan  diintegrasikan di  dalam  sistem  ini.  Tampilan yang  dibuat  akan  diuji  dengan melontarkan 14 pertanyaan ke 6 responden yang dirumuskan berdasarkan 6 aspek. Aspek-aspek yang dimaksud adalah: attractiveness, perspicuity, efficiency, dependability, stimulation, dan novelty. Nilai rata-rata dari masing- masing aspek adalah: 5.71, 5.58, 5.39, 5.08, 5.92, dan 5.83  dari nilai maksimal 7  secara berurutan. Berdasarkan hasil survei tersebut, dapat disimpulkan bahwa aplikasi ini mungkin dapat menolong orang tunanetra untuk bernavigasi layaknya orang awam
Perancangan Sistem Informasi Penyewaan Alat Surfing di Pantai Balangan Berbasis Web
Authors: Suatha I Made , Utama I Wayan Oka Wira , Rahardian Rifky Lana
Published: February 2022

Pantai Balangan merupakan salah satu kawasan wisata yang berada di Kabupaten Badung, Bali. Pantai Balangan memiliki sejumlah fisilitas seperti restoran, bar dan wisata. Beragam aktifikas wisata wisata seperti berjemur dan surfing dapat dilakukan di pantai Balangan. Pantai Balangan menjadi salah satu tempat untuk bermain surfing yang ada di Kabupaten Badung. Disini penulis membuat sistem informasi pemesanan alat surfing yang bertujuan untuk memudahkan pengunjung atau peselancar untuk mendapatkan alat surfing yang di butuhkan. Dimana pengunjung atau peselancar masih menggunakan cara manual untuk mencari tempat penyewaan alat surfing. Metode yang digunakan adalah metode waterfall, metode waterfall adalah salah satu jenis model pengembangan aplikasi melalui pengumpulan data. Pengumpulan data dilakukan dengan cara melakukan survey, wawancara dengan pihak terkait.
Sistem Pakar Untuk Mendeteksi Kerusakan Sistem Pendingin pada Mobil Toyota Menggunakan Metode Backward Chaining
Authors: Sumarno Sumarno
Published: February 2022

Kerusakan yang biasa terjadi secara tiba-tiba dan tidak dapat langsung terdeteksi oleh pemilik mobil karena minimnya pengetahuan tentang mesin mobil membuat para pengguna mobil menjadi bingung dan panik serta tidak bisa menangani mobilnya untuk sementara waktu sebelum mobil yang rusak dibawa ke bengkel terdekat. Oleh karena itu dibutuhkan suatu aplikasi yaitu sistem pakar yang merupakan suatu program komputer berbasis pengetahuan dari seorang pakar yang dapat membantu mengurangi resiko kerusakan mobil dengan mengetahui dmana sudah diketahui kerusakan kemudian dicari penyebabnya. Sehingga melalui aplikasi yaitu sistem pakar ini dapat mempermudah, membantu dan mengetahui penyebab-penyebab kerusakan yang terjadi pada sistem pendingin mobil Toyota.
Antena Mikrostrip Lingkaran untuk Komunikasi MIMO 4x4 pada Frekuensi 15 GHz
Authors: Utami Eva Yovita Dwi , Novaldy Jesicha Claudya , Febrianto Andreas Ardian
Published: February 2022

Pada jurnal ini dirancang dan direalisasikan antena mikrostrip patch lingkaran  MIMO 4x4 array 2 elemen yang bekerja pada frekuensi 15 GHz. Antena yang dirancang disimulasikan dengan menggunakan software CST Microwave Studio 2018. Bahan substrat yang digunakan adalah Duroid 5880, Simulasi rancangan antena menghasilkan return loss sebesar -22,557 dB, VSWR dengan nilai 1,1611, mutual coupling bernilai -40,525 dB lebar pita sebesar 1,482 dan gain mencapai 9,69 dB pada frekuensi resonansi 15 GHz. Antena yang direalisasikan berukuran 40x60,64 mm. Dari hasil pengukuran antena yang telah direalisasikan, diperoleh nilai return loss sebesar -26,8709 dB, VSWR sebesar 1,095, bandwidth sebesar 1,6 GHz dengan rentang frekuensi 14 GHz – 15,6 GHz, dan gain sebesar 14,39 dB pada frekuensi kerja 15 GHz.
Autopsia del currículo: En búsqueda de las causas del colapso educativo en tiempos del COVID-19
Authors: Toruño Arguedas César
Published: February 2022

Las implicaciones del virus SARS-CoV-2 (conocido socialmente como coronavirus o COVID-19) han transformado las realidades sociales, políticas, económicas y culturales a nivel global; esto incluye afectaciones al sistema educativo que, en la mayoría de los países occidentales, ha implicado la suspensión del ciclo lectivo por largos períodos como respuesta ante la incapacidad del sistema para adaptarse a una realidad virtual, según la tesis más aceptada. El presente ensayo sostiene que la incapacidad de adaptación del sistema educativo es producto de una serie de enfermedades latentes en el currículo educativo, motivo por el cual se procede a realizar una autopsia del currículo. Se concluye que el currículo padecía de graves enfermedades que, al ser sometidas al cambio de modalidad presencial a virtual, ocasionaron el colapso del sistema educativo tradicional.
DNA metabarcoding reveals impact of local recruitment, dispersal, and hydroperiod on assembly of a zooplankton metacommunity
Authors: Kiemel Katrin , Weithoff Guntram , Tiedemann Ralph
Published: February 2022

How the environment impacts the assembly of local communities as well as
their spatial and temporal connection in a metacommunity has remained a
largely unresolved question in community ecology. This study aims to
unravel the underlying metacommunity dynamics and environmental factors
that result in observed zooplankton communities. In extension to most
studies concerning metacommunity dynamics, we jointly examine
zooplankton communities both in open water and in the sediment where
zooplankton resting stages/dormant communities are stored. We used a
two-fragment DNA metabarcoding approach (COI and 18S) to monitor
zooplankton communities of 24 kettle holes over a two-year period to
unravel (I) how the community is spatially and temporally connected,
(II) what are the environmental factors influencing local communities,
and (III) what are the underlying metacommunity dynamics in this system.
We found a strong separation of zooplankton communities from kettle
holes of different hydroperiods (ephemeral vs. permanent) throughout the
season, while the community composition within single kettle holes did
not differ between years. Species richness was primarily dependent on pH
and hydroperiod, while species diversity was influenced by kettle hole
location. Community composition was further impacted by kettle hole
size, water temperature and pH. Soil samples showed a separate community
composition compared to water samples, but did not differ between
ephemeral and permanent kettle holes. Our results suggest that
communities are mainly structured by environmental filtering based on
pH, water temperature, kettle hole size and hydroperiod. Species sorting
is a dominant driver in community assembly in the studied kettle hole
zooplankton metacommunity.
A case of myopericarditis following administration of the Pfizer COVID-19 vaccine
Authors: Morton Zoey , Green Danetta , Grisham Matt
Published: February 2022

Numerous vaccines have been developed to address the COVID-19 pandemic, the most frequently administered are the Moderna and Pfizer-BioNTech (Pfizer) mRNA COVID-19 vaccines. Of 177 million individuals that have full vaccination status, there have been 1,148 cases of myocarditis or pericarditis reported. At this time, the relationship between myopericarditis and the Pfizer mRNA COVID-19 vaccine has not been well established in current literature due to the novelty of the vaccine. We discuss a 16-year-old male who presented to the emergency department with chest pain 48 hours after receiving his second dose of the Pfizer COVID-19 vaccine. His laboratory and electrocardiogram findings were consistent with acute myopericarditis and work-up did not reveal an obvious etiology. After starting anti-inflammatory therapies, the patient’s symptoms and laboratory markers improved and the patient was discharged from the hospital expected to make a full recovery. This case demonstrates the rapid recovery with no sequelae following this adverse effect, highlighting that the benefits of the COVID-19 vaccination most likely outweigh the risks.
The Effect of External Monitoring on Conservative Financial Reporting in the Property-Casualty Insurance Industry
Authors: Reddic Willie D , Bisco Jill , Booker Kayla D
Published: February 2022

When property-casualty (P&C) insurers understate their loss reserves, they increase the appearance of solvency. Understating loss reserves can lead to inadequate loss protection for policyholders. This paper investigates the effect of external monitoring by state regulators on financial reporting by P&C insurers. Specifically, we analyze whether a regulatory financial examination of P&C insurers, as mandated and conducted by state law, results in reporting more conservative loss reserve estimates. We find that P&C insurers report more conservative loss reserve estimates during and following a regulatory financial examination. Whereas past studies use audits as external monitoring events around which fluctuations in loss reserves are observed, we focus on regulatory financial examinations as external monitoring events that mitigate the use of loss reserves to manage perceptions of company health.

JEL Classifications: G22; H79; M42; M48.
Persistence of Risk for Type 2 Diabetes After Gestational Diabetes Mellitus
Authors: Diaz-Santana Mary V. , O’Brien Katie M. , Park Yong-Moon Mark , Sandler Dale P. , Weinberg Clarice R.
Published: February 2022

OBJECTIVE

Gestational diabetes mellitus complicates ∼6% of pregnancies and strongly predicts subsequent type 2 diabetes. It has not been fully elucidated how risk depends on the number of affected pregnancies or how long the excess risk persists.

RESEARCH DESIGN AND METHODS

We assessed reproductive histories in relation to risk of type 2 diabetes using a nationwide cohort of 50,884 women. Among participants who initially did not have diabetes, 3,370 were diagnosed with diabetes during 10 years of follow-up. We used Cox proportional hazards models that allowed risk to depend on age, cumulative number of pregnancies with gestational diabetes mellitus, and time since the most recent affected pregnancy, adjusting for BMI, educational level, and race/ethnicity.

RESULTS

History of one or more pregnancies with gestational diabetes mellitus predicted elevated age-specific risk of type 2 diabetes, with a hazard ratio of 3.87 (95% CI 2.60–5.75) 6–15 years after an affected pregnancy. Risk increased steeply with multiple affected pregnancies. The age-specific associations attenuated over time after an affected pregnancy, with an estimated 24% reduction of the hazard ratio per decade. Risk remained elevated, however, for >35 years.

CONCLUSIONS

Gestational diabetes mellitus predicted markedly increased rates of type 2 diabetes. Relative risk increased substantially with each additional affected pregnancy. The estimated hazard ratio declined with time after a pregnancy with gestational diabetes mellitus but remained elevated for >35 years. Women recalling a history of gestational diabetes mellitus should be screened regularly for type 2 diabetes, even late in life.
Vizual'nyj analiz nigrosomy-1 v differencial'noj diagnostike bolezni Parkinsona i essencial'nogo tremora
Authors: Москаленко А. Н. , Филатов А. С. , Федотова Е. Ю. , Коновалов Р. Н. , Иллариошкин С. Н.
Published: February 2022

Differencial'naya diagnostika bolezni Parkinsona i fenotipicheski skhozhego dvigatel'nogo rasstrojstva — essencial'nogo tremora, osobenno v debyute zabolevaniya, ostaetsya odnoj iz nereshennyh zadach sovremennoj nevrologii. Cel'yu issledovaniya bylo ocenit' diagnosticheskuyu znachimost' vizualizacii nigrosom — klasterov dofaminergicheskih nejronov v chernoj substancii (CHS) srednego mozga, vyyavlyaemyh pri ispol'zovanii SWIrezhima vysokorazreshayushchej magnitno-rezonansnoj tomografii (3 Tesla), u 20 pacientov s bolezn'yu Parkinsona i u 10 pacientov s essencial'nym tremorom. Vizual'nyj analiz izobrazhenij nigrosomy-1 provodili s ispol'zovaniem chetyrekhchlennoj poryadkovoj shkaly. Razlichiya po gendernomu, vozrastnomu sostavu i prodolzhitel'nosti zabolevaniya rasschityvali s pomoshch'yu tochnogo kriteriya Fishera, U-kriteriya Manna–Uitni. Dlya rascheta diagnosticheskoj cennosti dannoj metodiki ispol'zovali kriterij χ2 Pirsona. U pacientov s bolezn'yu Parkinsona v 70% sluchaev nablyudali odno- ili dvustoronnee ischeznovenie nigrosomy-1. Eshche u dvuh pacientov s bolezn'yu Parkinsona (10%) vyyavili menee specifichnye izmeneniya chernoj substancii — umen'shenie ob"ema nigrosomy-1. Naprotiv, u vsekh pacientov s essencial'nym tremorom (100%) nigrosoma-1 ostavalas' sohrannoj s dvuh storon (p < 0,001). Poluchennye predvaritel'nye rezul'taty demonstriruyut vysokij potencial metodiki vizual'nogo analiza nigrosomy-1 v differencial'noj diagnostike bolezni Parkinsona i essencial'nogo tremora.
The importance of determining the uromodulin serum concentration in diabetes mellitus type 2 patients
Authors: Jordanova Elena , Samardžić Vladimir , Peković-Peruničić Gordana , Tica-Jevtić Jelena , Simić-Ogrizović Sanja
Published: February 2022

Introduction: In the kidney, cells in the thick ascending limb of the loop of the Henle synthesized uromodulin (UMOD). This study aims to present the evaluation of the uromodulin serum concentration in diabetes mellitus type 2 (T2DM) patients in the early detection of kidney damage. Materials and methods: The study included 50 T2DM patients mean age of 60.75 ± 11.23 years estimated glomerular filtration rate (eGFR) 114.38 ± 22.12 ml/min and a control group of 20 healthy persons. We measured serum concentration of haemoglobin, urea, creatinine, uromodulin (ELISA method), and cystatin C (nephelometry). We determined formulas: Cockcroft-Gault# (combination Cockcroft-Gault for patients with BMI < 30 kg/m2 and Cockcroft-GaultLBW for patients with BMI ≥ 30 kg/m2), CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration equation), and simple Cystatin C. Results: T2DM patients had lower hemoglobin serum concentration as well as eGFR calculated by formulas: Cockcroft-Gault# and CKD-EPI. T2DM patients had significantly higher BMI and cystatin C compared to control group. T2DM patients had significantly lower serum uromodulin concentration (136.51 ± 84.34 vs 220.50 ± 92.39 ng/ml) than in controls. Significant positive correlation between uromodulin and Cockcroft-Gault# (r = 0.432, p = 0.000), CKD-EPI (r = 0.439; p = 0.000) formulas as well as simple cystatin C (r = 0.250, p = 0.02), but negative correlation with age (r = -0.476, p = 0.000), BMI (r = -0.313, p = 0.002) and cystatin C serum concentration (r = -0.293, p = 0.015) were found. Conclusion: The role of serum uromodulin concentration is not still fortified. The results of this study showed that reduced uromodulin serum concentration indicated early kidney damage in T2DM patients.
Drummond e o existencialismo
Authors: Oliveira Cleide Maria
Published: February 2022

O artigo faz leitura direcionada de um corpus de poemas selecionados de Carlos Drummond de Andrade, no qual, sem pretensões de uma interpretação totalizante de sua obra, busca a compreensão de temas, assuntos e figuras afins à filosofia existencialista, conforme disseminada por Jean-Paul Sartre. A conclusão a que se chega é a de que, embora não seja possível identificar influências diretas do existencialismo na poesia de Drummond, nota-se temas e abordagens comuns entre ele e a sua poesia, principalmente no que diz respeito à compreensão de uma radical temporalidade própria ao homem aliada ao exílio da liberdade, o que o torna persona de seu tempo e construtor de si mesmo.
STRATEGI PENJUALAN DI MARKETPLACE SHOPEE UNTUK MENINGKATKAN PENJUALAN SEPATU KULIT PADA 10 UMKM DI CIBADUYUT BANDUNG
Authors: Suhayati Ely , Supriatna Nizar Nugraha
Published: February 2022

The existence of PPKM due to Covid-19 has made MSMEs the most affected due to losing purchasing power, because people are afraid of contracting the virus so they cannot shop directly to the store, in order to survive, MSMEs must be able to use technology to increase sales through the marketplace so that people can shop online. MSME who utilizes technology in their business, prove to be stronger in facing of the external shocks. The purpose of this community service is how MSMEs can apply how to design, upload, and create promos in the shopee marketplace as a product sales strategy. The method used qualitatively using interviews and observation techniques with the delivery of material using the zoom meeting application. The result of community service is training on how to design advertisements, then uploading them and making promos virtually in addition to using the Zoom Meeting application, also providing Video Files in the form of E-Course Marketplace Shopee, as well as providing consultation via Whatsapp without a time limit if there are difficulties when implementing it for 10 MSMEs Shoes in Cibaduyut. Conclusion 10 Leather Shoes’s MSMEs in Cibaduyut after training in virtual application using the zoom meetings were able to design a shop in the marketplace shopee and upload the photos of their product and make promos to attract more buyers to introduce Local Brand means that 10 MSMEs Shoes Cibaduyut able to apply to advertise in shopee for sell more products so as to increase sales, through selling strategies in the marketplace.
PEMBERDAYAAN KELOMPOK PKK DALAM PENGELOLAAN SAMPAH RUMAH TANGGA BERBASIS 3R TERINTEGRASI BANK SAMPAH DI DESA CIBODAS, KECAMATAN PASIRJAMBU, KABUPATEN BANDUNG
Authors: Indrawati Dwi , Purwaningrum Pramiati , Ruhiyat Ratningsih , Indrawati Etty
Published: February 2022

Community empowerment, which is the practice of implementing 3R by utilizing or recycling household solid waste, aims to increase the community's knowledge and skills in utilizing household solid waste into economic value products. Having this knowledge and skills will increase people's interest and willingness to use household solid waste, which in turn will maintain environmental quality by reducing the amount of solid waste and making the environment greener. This community service activity in Cibodas Village, Pasirjambu District starts from the preparation, implementation, monitoring, and evaluation stages, as well as preparing reports and activity outputs. Activities are carried out offline while still observing health protocols, which are mandatory to wear masks, maintain distance, and always wash hands with soap and running water or use hand sanitizers. In this activity, the implementation is carried out by utilizing material delivery technology through the MS Power point application, delivery interactions through banners/posters, demonstrations of waste sorting and processing practices, as well as the design of 3R-based household waste management patterns that are integrated with the Waste Bank. In the implementation of counseling and training held at the Cibodas Village Office, all participants seemed enthusiastic in gaining additional knowledge and skills in 3R-based household solid waste management and had the motivation to change behavior in placing solid waste in segregated containers.
PENGUKURAN DAN PERPAJAKAN DIGITAL EKONOMI DI INDONESIA
Authors: Sululing Siswadi
Published: February 2022

Tujuan dari penelitian ini adalah untuk memberikan gambaran mengenai pengukuran dan pajak penghasilan dari transaksi digital ekonomi di Indonesia.Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kepustakaan. Populasi yang digunakan adalah artikel yang pernah dikunjungi, sedangkan sampel yang digunakan adalah purposive sampling dengan kriteria sebagai berikut: artikel yang pernah dipublikasikan, terindeks sinta dan bereputasi internasional serta dikutip, sehingga diperoleh lima puluh sampel.Metode analisis data yang digunakan adalah analisis isi. Hasil kajian, terdapat tiga pendekatan untuk mengukur digital ekonomi, yaitu: pendekatan dampak langsung, pendekatan dampak dinamis dan pendekatan dampak tidak langsung. Sementara itu, pengukuran digital ekonomi yang dilakukan Indonesia menggunakan pendekatan dampak langsung produk domestik bruto (PDB). Sedangkan perpajakan digital ekonomi yang diterapkan di Indonesia adalah menggunakan peraturan perundang-undangan (Perpu) No. 1 Tahun 2020 Kebijakan Perpajakan Pasal 4 sd 7 dan Peraturan Menteri Keuangan (PMK) No. 48 Tahun 2020 sebagai turunan dari Perpu tersebut, yakni pelaku kegiatan perdagangan melalui sistem elektronik (PMSE).
Preparation and properties of bio-lubricants of neopentylglycol esters from various acids
Authors: Lakkoju Babi , Vemulapalli Vandana
Published: February 2022

In this work, two different neopentyl glycol (NPG) esters have been synthesized from NPG with 10- undecylenic acid (UDA) and calophyllum fatty acid (CFA) by the esterification process by using para toluene sulfonic acid as a catalyst. The esterification reaction progress has been determined by collecting measured water by using the Dean Stack apparatus. The prepared ester structures have been characterized by NMR, IR and the general physico-chemical behaviors such as density, viscosity, flash point, pour point and copper strip corrosion were determined. Moreover, these prepared ester properties have been compared to commercial ISO VG grade lubes.
TEACHER PROFESSIONAL DEVELOPMENT IN THE PERSPECTIVE OF TECHNOLOGY PEDAGOGICAL CONTENT KNOWLEDGE THEORETICAL FRAMEWORK
Authors: Ginting Daniel , Linarsih Andini
Published: February 2022

Teacher development is an ongoing process through which teachers keep growing with their capabilities. They must be adaptive to the demands of changing times and open to self-professional development. Today, teacher development is challenged to develop not only mastery of science and teaching abilities but also technology. In the perspective of Technology Pedagogical Content Knowledge (TPACK), the meeting of these three competence dimensions can be further divided into seven sub-competencies: technological knowledge, pedagogical knowledge, knowledge of course content, technological pedagogical knowledge, technological content knowledge, pedagogical content knowledge, and technological pedagogical content knowledge. This paper ends with pedagogic implications for teacher professional development that demands high quality and perceived as valuable.
Quantum security of AES-128 under HHL algorithm
Authors: Gao Juntao , Li Hao , Wang Baocang , Li Xuelian
Published: February 2022

There have been a lot of researches about algebric analysis of AES. In this paper, we turned to quantum algorithm to analyze security of AES-128 against the modified HHL algorithm, which is a quantum algorithm used to get classical solutions of multivariate equation system. We constructed two types of equation systems of AES, and solved them with several variants of HHL algorithms respectively. The resulting complexities involved the condition number are given. We analyzed the reasons for the different complexity of the two equation systems and their solution methods, and pointed out that the combination of the boolean equation system and (the improved) BoolSol is more threatening to AES. With a lower bound on the condition number presented by Ding et al., we show that, for AES-128, HHL algorithm is difficult to achieve better attack effect than Grover algorithm. Our results have some enlightening significance for analyzing the post-quantum security of AES-like block ciphers.
Tensin Phosphatase-Like System of Hantavirus Facilitates Membrane Fusion to Disrupt Vascular permeability
Authors: liu wenzhong , li hualan
Published: February 2022

Increased vascular permeability is a characteristic of Hantavirus illness, for which there is now no treatment. We employed the domain search method to investigate the Hantavirus protein in this present work. The results indicated that the membrane glycoprotein E protein (containing Gn-Gc) of Hantavirus had lipid phosphatase and C2-like domains. The E protein was a tensin phosphatase-like (PTEN) enzyme that could shuttle in the cytoplasm and cell membrane. In an acidic endosomal environment, Gn dissociates, exposing Gc's autophosphorylation region to complete autophosphorylation and activating the C2 domain. The C2 domain facilitates Gc's conformational transition, which is followed by Gc binding to the endosomal membrane. After being inserted into the endosomal membrane, the phosphatase domain of Gc phosphorylates PI(3,4,5)P3 on the endosomal membrane. Then converted PI(3,4,5)P3 to PI(4,5)P2 . PI(4,5)P2 bound to the N-terminal of Gc, completely anchoring the tetramer-shaped Gc to the endosomal membrane and forming a fusion hole. Then analogous to PTEN, phosphorylation of PI(3,4,5)P3 directly induced the disintegration of Gc tetramer. The enlargement of the fusion pore speeded up the fusion of the viral and endosomal membranes. Through the fusion hole, the virus's intracellular material was swiftly discharged into the cytoplasm. The C2 domain promoted the PKC signaling route during Hantavirus membrane fusion, whereas the phosphatase inhibited the PI3K signaling pathway. E protein's PTEN-like action impaired lipid metabolism and endothelial cell remodeling, increasing blood vessel permeability and resulting in renal and cardiac syndromes. Additionally, E protein inhibited the immune system and Akt-mediated eNOS activation, resulting in a cascade of consequences.
Structural requirements for photo-induced RNA-protein cross-linking
Authors: Knörlein Anna , Sarnowski Chris , de Vries Tebbe , Stoltz Moritz , Götze Michael , Aebersold Ruedi , Allain Frédéric , Leitner Alexander , Hall Jonathan
Published: February 2022

Understanding structure-function relationships of RNA-binding proteins requires knowledge of how they bind RNAs in vivo. RNA-protein interactions are studied using light-induced cross-linking at “zero-distance”, yielding nucleotide/amino-acid adducts for mass-spectrometry (MS)-based characterization. However, prerequisites for cross-linking are poorly understood, limiting interpretation of cross-linking data. Here, we report novel insights on cross-linking requirements from studying RBFOX-RRM domain bound to 13C-labeled variants of its heptaribonucleotide binding element as a model. We probed the influence of nucleotide identity, sequence position and amino-acid composition using tandem-MS to assign cross-links at site-specific resolution. We observed cross-linking at three nucleotides, which were stacked onto phenylalanines. Surprisingly, this stacking was required for neighbouring amino-acids to cross-link, and is apparent in published RNA-protein datasets. We hypothesize that π-stacking activates cross-linking via electron transfer, whereafter nucleotide- and peptide radicals, possibly stabilized by capto-dative effects, recombine. These findings should facilitate interpretation of cross-linking data from structural studies and genome-wide datasets.
Revealing Carbon Capture Chemistry with 17-Oxygen NMR Spectroscopy
Authors: Berge Astrid , Pugh Suzi , Short Marion , Lu Ziheng , Lee Jung-Hoon , Pickard Chris , Forse Alexander
Published: February 2022

Carbon dioxide capture is an essential greenhouse mitigation technology to achieve net-zero emissions. A key hurdle to the design of improved carbon capture materials is the lack of adequate tools to characterise how CO2 adsorbs. Solid-state nuclear magnetic resonance (NMR) spectroscopy is emerging as a promising probe of CO2 capture, but it remains challenging to distinguish different adsorption products. Here we perform a comprehensive computational investigation of 22 amine-functionalised metal-organic frameworks and discover that 17O NMR is a powerful probe of CO2 capture chemistry that provides excellent differentiation of ammonium carbamate and carbamic acid species. The computational findings are supported by 17O NMR experiments on a series of CO2-loaded frameworks that clearly identify ammonium carbamate chain formation and provide new evidence for a mixed carbamic acid – ammonium carbamate adsorption mode. The fine sensitivity of 17O NMR to local chemistry also shows that hydrogen bonding schemes proposed in previous ammonium carbamate chain structures may be inaccurate and new structures are proposed. Finally, we discover a new mixed CO2 adsorption mechanism and show that carbamic acid formation is more prevalent in this materials class than previously believed. Our work paves the way for new investigations of carbon capture chemistry that can enable the design of improved materials.
A systematic comparison of the structural and dynamic properties of commonly used water models for molecular dynamics simulations
Authors: Kadaoluwa Pathirannahalage Sachini P. , Meftahi Nastaran , Elbourne Aaron , Weiss Alessia C. G. , McConville Chris F. , Padua Agilio , Winkler David A. , Costa Gomes Margarida , Greaves Tamar L. , Besford Quinn A. , Le Tu C. , Christofferson Andrew J.
Published: February 2022

Water is a unique solvent that is ubiquitous in biology and present in a variety of solutions, mixtures, and materials settings. It therefore forms the basis for all molecular dynamics simulations of biological phenomena, as well as for many chemical, industrial, and materials investigations. Over the years, many water models have been developed, and it remains a challenge to find a single water model that accurately reproduces all experimental properties of water simultaneously. Here, we report a comprehensive comparison of structural and dynamic properties of 30 commonly used 3-point, 4-point, 5-point, and polarizable water models simulated using consistent settings and analysis methods. For the properties of density, coordination number, surface tension, dielectric constant, self-diffusion coefficient, and solvation free energy of methane, models published within the past two decades consistently show better agreement with experimental values compared to models published earlier, albeit with some notable exceptions. However, no single model reproduced all experimental values exactly, highlighting the need to carefully choose a water model for a particular study, depending on the phenomena of interest. Finally, machine learning algorithms quantified the relationship between the water model force field parameters and the resulting bulk properties, providing insight into the parameter-property relationship and illustrating the challenges of developing a water model that can accurately reproduce all properties of water simultaneously.
Development of chimeric molecules that degrade the estrogen recep-tor using decoy oligonucleotide ligands
Authors: Naganuma Miyako , Ohoka Nobumichi , Tsuji Genichiro , Tsujimura Haruna , Matsuno Kenji , Inoue Takao , Naito Mikihiko , Demizu Yosuke
Published: February 2022

Targeted protein degradation using chimeric small molecules, such as proteolysis-targeting chimeras (PROTACs) and specif-ic and nongenetic inhibitors of apoptosis protein [IAP]-dependent protein erasers (SNIPERs), has attracted attention as a method to degrade intracellular target proteins via the ubiquitin-proteasome system (UPS). These chimeric molecules target a variety of proteins using small molecules that can bind to the proteins. However, it is difficult to develop such degraders in the absence of suitable small molecule ligands for the target proteins, such as for transcription factors (TFs). Therefore, we constructed the chimeric molecule LCL-ER(dec), which consists of a decoy oligonucleotide that can bind to the estrogen receptor alpha (ERalpha) and an IAP ligand, LCL161 (LCL), in a click reaction. LCL-ER(dec) was found to selectively degrade ERalpha via the UPS. These findings will be applicable to the development of other oligonucleotide-type degraders that target different TFs.
Precise and Long-Term Tracking of Mitochondria in Neurons using a Bioconjugatable and Photostable AIE Luminogen
Authors: Park Hojeong , Niu Guangle , Wu Chao , Park Chungwon , Park Hyokeun , Kwok Ryan T. K. , He Benzhao , Tang Benzhong
Published: February 2022

Tracking mitochondrial movement in neurons is an attractive research field as dysregulation of mitochondrial motion is associated with multiple neurological diseases. To attain the precise trajectory of a single mitochondrion and achieve long-term imaging of mitochondria in neurons, specific and photostable fluorescent probes with a long emission lifetime are required. Existing mitochondrial targeting fluorescent dyes suffer from poor photostability, high toxicity, “always-on” behavior, and aggregation-caused quenching effect, which limit their use in studying mitochondria in neurons. To overcome these challenges, we designed and synthesized an aggregation-induced emission (AIE)-active luminogen, TPAP-C5-yne, which consists of an activated alkyne terminus for bioconjugation with amines, and a cationic pyridinium moiety to selectively target mitochondria. For the first time using TPAP-C5-yne, we successfully tracked and analyzed the motion of a single mitochondrion in live primary hippocampal neurons accurately using real-time fluorescence images acquired by a sensitive EMCCD camera. In addition, long-term imaging of mitochondria in live neurons for a week is achieved by TPAP-C5-yne, which was not feasible with a commercially available mitochondrial targeting probe before.
Regiocontrolled Allylic Functionalization of Internal Alkene via Selenium-pi-Acid Catalysis Guided by Boron Substitution
Authors: Honggen Wang , Yang Ling , Liu Yuan , Fan Wen-Xin , Tan Dong-Hang , Li Qingjiang
Published: February 2022

The selenium-pi-acid-catalysis has received increasing attention as powerful tools for olefin functionalization, but the regioselectivity is often problematic. Reported herein is a selenium-catalyzed regiocontrolled olefin transpositional chlorination and imidation reaction. The reaction outcome benefits from an allylic B(MIDA) substitution. And the stabilization of α-anion from a hemilabile B(MIDA) moiety was believed to be the key factor for selectivity. Broad substrate scope, good functional group tolerance and generally good yields were observed. The formed products were demonstrated to be valuable precursors for the synthesis a wide variety of structurally complex organoborons.
Selenium Valence-to-Core X-ray Emission Spectroscopy and Kβ HERFD X-ray Absorption Spectroscopy as Complementary Probes of Chemical and Electronic Structure
Authors: Henthorn Justin T. , DeBeer Serena
Published: February 2022

Selenium X-ray absorption spectroscopy (XAS) has found widespread use in investigations of Se-containing materials, geochemical processes, and biological active sites. In contrast to sulfur Kβ X-ray emission spectroscopy (XES), which has been found to contain electronic and structural information complementary to S XAS, Se Kβ XES remains comparatively under-explored. Herein, we present the first Se Valence-to-Core (VtC) XES studies of reduced Se-containing compounds and FeSe dimers. Se VtC XES is found to be sensitive to changes in covalent Se bonding interactions (Se–Se/Se–C/Se–H bonding) while relatively insensitive to changes in Fe oxidation states as selenide bridges in FeSe dimers ([Fe2Se2]2+ vs [Fe2Se2]+). Contrastingly, Se Kβ HERFD XAS is demonstrated to be quite sensitive to changes in Fe-oxidation state, with Se Kβ HERFD XAS demonstrating experimental resolution equivalent to K𝛼 HERFD XAS. Additionally, computational studies reveal both Se VtC XES and XAS to be sensitive to selenium protonation in FeSe complexes.
2-Diphenylphosphinoyl-acetyl as a remote directing group for the highly stereoselective synthesis of β-glycosides
Authors: Liu Xianglai , Lin Yetong , Sun Qianhui , Sun Huiyong , Xu Peng , Li Guolong , Song Yingying , Xie Weijia , Sun Haopeng , Yu Biao , Li Wei
Published: February 2022

The configuration of the anomeric glycosidic linkages is crucial for maintaining the biological functions and activities of carbohydrate molecules. However, their stereochemistry control in glycosylation represents one of the most challenging tasks in carbohydrate chemistry. In this report, the easily accessible 2-diphenylphosphinoyl-acetyl (DPPA) group was developed as a highly stereodirecting group for catalytic glycosylation via hydrogen-bond mediated delivery of the alcoholic acceptors. TMSOTf-catalyzed glycosylation with 6-O-DPPA glycosyl imidate donors displayed excellent β-selectivity and broad substrate scope, particularly applicable to synthesize the challenging β-configured 2-deoxy- and 2-azido-2-deoxy-glycosides from electron-deficient or bulky acceptors. Chemoselective removal of the DPPA group could be readily achieved under the mild catalysis of Ni(OTf)2, and further application was demonstrated in the synthesis of biologically important oligosaccharides, uronic acids, and 2,6-dideoxy-glycosides.
Thioderivatives of Resorcin[4]arene and Pyrogallol[4]arene: Are thiols tolerated in the self-assembly process?
Authors: Nemat Suren , Tiefenbacher Konrad
Published: February 2022

Three novel thiol bearing resorcin[4]arene and pyrogallol[4]arene derivatives were synthesized. Their properties were studied with regards to self-assembly, Brønsted acid catalysis, and disulfide chemistry. One new thiosubstituted macrocycle stands out in particular, as it forms a hexameric capsule in CDCl3 capable of terpene cyclizations, dimerizes via disulfide bridges under mild oxidative conditions, and most importantly shows guest uptake of both alkyl ammonium salts and C60-fullerenes.
Native mass spectrometry guided screening identifies hit fragments for HOP-HSP90 PPI inhibition
Authors: Veale Clinton , Vaaltyn Michaelone , Mateos-Jimenez Maria , Müller Ronel , Mackay C. Logan , Edkins Adrienne , Clarke David
Published: February 2022

Contemporary medicinal chemistry considers fragment-based drug discovery (FBDD) and inhibition of Protein-Protein Interactions (PPI), as important means of expanding druggable chemical space. However, the ability to robustly identify valid fragments and PPI inhibitors is an enormous challenge, requiring the application of sensitive biophysical methodology. Accordingly, in this study, we exploited the speed and sensitivity of nano-ESI native mass spectrometry to identify a small collection of fragments, which bind to the TPR2AB domain of HOP. Further biological assessment of a small selection of binding fragments showed that this binding translated into PPI inhibitory activity between the TPR2A domain of HOP and the HSP90- C terminal domain. An in silico assessment of binding fragments, at the PPI interfacial region provided valuable structural insight for future fragment elaboration strategies, including the identification of losartan as a weak, albeit dose dependent inhibitor of the target PPI.
Oxidation of Electron-Deficient Phenols Mediated by Hypervalent Iodine(V) Reagents: Fundamental Mechanistic Features Revealed by a DFT-Based Investigation
Authors: Jalali Mona , Bissember Alex , Yates Brian , Wengryniuk Sarah , Ariafard Alireza
Published: February 2022

Hypervalent iodine(V) (HVI) compounds are highly efficient reagents for the double oxidative dearomatization of electron-rich phenols to o-quinones. We recently reported that an underexplored class of iodine(V) reagents possessing bidentate bipyridine ligands, termed Bi(N)-HVIs, could efficiently dearomatize electron-poor phenols for the first time. To better understand the fundamental mechanistic basis of this unique reactivity, density functional theory (DFT) was utilized. In this way, different pathways were explored to determine why Bi(N)-HVIs are capable of facilitating these challenging transformations while more traditional hypervalent species, such as IBX cannot. Our calculations reveal that the first redox process is the rate-determining step, the barrier of which hinges on the identity of the ligands bound to the iodine(V) center. This crucial process is composed of three steps: (a) ligand exchange, (b) hypervalent twist, and (c) reductive elimination. We found that strong coordinating ligands disfavour these elementary steps and, for this reason, HVIs bearing such ligands cannot oxidize the electron-poor phenols. In contrast, the weakly coordinating triflate ligands in Bi(N)-HVIs allow for the kinetically favorable oxidation of such phenols {e.g., G‡ = ~22 kcal/mol where Bi(N) = Bi(4-CO2Etbipy)}. It was also identified that trapping triflic acid, which is generated in situ, is a key role played by the basic bidentate bipyridine ligands in Bi(N)-HVIs as this serves to minimize decomposition of the sensitive ortho-quinone product.