bluuebunny/crossref_metadata_2025 huggingface dataset:
The Immunologic Downsides Associated with the Powerful Translation of Current COVID-19 Vaccine mRNA Can Be Overcome by Mucosal Vaccines
Authors: Federico Maurizio
Published: November 2024

The action of mRNA-based vaccines requires the expression of the antigen in cells targeted by lipid nanoparticle–mRNA complexes. When the vaccine antigen is not fully retained by the producer cells, its local and systemic diffusion can have consequences depending on both the levels of antigen expression and its biological activity. A peculiarity of mRNA-based COVID-19 vaccines is the extraordinarily high amounts of the Spike antigen expressed by the target cells. In addition, vaccine Spike can be shed and bind to ACE-2 cell receptors, thereby inducing responses of pathogenetic significance including the release of soluble factors which, in turn, can dysregulate key immunologic processes. Moreover, the circulatory immune responses triggered by the vaccine Spike is quite powerful, and can lead to effective anti-Spike antibody cross-binding, as well as to the emergence of both auto- and anti-idiotype antibodies. In this paper, the immunologic downsides of the strong efficiency of the translation of the mRNA associated with COVID-19 vaccines are discussed together with the arguments supporting the idea that most of them can be avoided with the advent of next-generation, mucosal COVID-19 vaccines.
Schwannomatosis
Authors: Dehneh Younes , Khay Hamid , Khoulali Mohamed , Faycal Moufid
Published: November 2024

Schwannomatosis is characterized by a predisposition to develop multiple schwannomas and rarely meningiomas. People with schwannomatosis are most commonly present between the second and fourth decades of life. The most common feature is localized or diffuse pain or an asymptomatic mass. Schwannomas most commonly involve peripheral and spinal nerves. We report the case of a woman who was initially referred to our department because of suspected neurofibromatosis type 2.
Skull base-cranio-facial trauma with dura mater repair after subsequent CSF leaking, diagnosis treatment and outcomes
Authors: Encarnación Santos Daniel , Chmutin Gennady , Chaurasia Bipin
Published: November 2024

Background. Since there is a chance of serious neurological consequences, it is critical to demonstrate the diagnosis and treatment of craniofacial trauma with aetiologies such as extreme sports, motor vehicle accidents, and social trauma. Examining the effectiveness of methods for restoring the Dura after severe craniofacial and skull-base damage made worse by rhinorrhea and CSF leakage is our goal.
Methodology. In accordance with PRISMA (Preferred Reporting Items for Systematic Reviews) criteria, a systematic review was conducted. The following search terms were used: "Articles criticizing the analysis of open penetrating craniofacial injury with concurrent CSF leakage from the cranial cavity were examined and included, and associated pathologies, especially severe trauma of the upper and middle regions of the anterior cranial fossa." Rayyan - Intelligent Systematic Review Software A thorough search was conducted in databases like ScienceDirect and PubMed/MEDLINE before employing IBM SPSS Statistics for Windows, Version 26.0 (Released 2020; IBM Corp., Armonk, New York, United States), and EXCEL criteria for the statistical analysis.
Results. A total of 1584 patients with cerebrospinal fluid leaks were included in this investigation. Additionally, 698 patients were shown in Table 1 figure 2 and 886 patients in Table 2, figure 3-4-5. Rhinorrhea following trauma to the base of the skull, or craniofacial, was corrected by transnasal endoscopy in most cases and extracranial approach or craniotomy in fewer cases.
Conclusion. A thorough analysis of the outcomes within the context of healthcare reveals: 1. The efficacy of polyoxybutyrate membrane-based multilayer D-plasty. 2. This evaluation clarified that the inferred further planning for surgical suture material development was made.
Delayed post traumatic CSF rhinorrhoea
Authors: Jadhav Anil , Katyal Abhishek , Jagetia Anita , Srivastava A.K. , Singh Daljit
Published: November 2024

Cerebrospinal fluid (CSF) leak can occur immediately or several years after traumatic skull base injury which may present merely as a CSF leak or may even present with recurrent meningitis. Around 2% of all cases of head trauma, and 12%–30% of all basilar skull fractures may develop CSF leak. Posttraumatic CSF rhinorrhoea usually occurs within the first 48 hours, and the majority of them occur in the first 3 months, whereas delayed CSF leak beyond 3 months is rare.
We encountered two such cases of delayed post-traumatic CSF rhinorrhoea about a decade after the head injury. We have reviewed and discussed previous studies on delayed post-traumatic CSF rhinorrhoea which have shown CSF leaks occur after months, years, or even after trauma. Such cases may help clinicians to be aware of the possibility of delayed CSF rhinorrhoea which may occur years after traumatic head injury.
THE ROLE OF DYNAMIC MYELOGRAPHIC TECHNIQUES IN IDENTIFYING SPINAL DURAL LEAKS IN INTRACRANIAL HYPOTENSION SYNDROME
Authors: Radu Razvan Alexandru , Dorobat Bogdan
Published: November 2024

Spontaneous intracranial hypotension (SIH) presents a unique diagnostic and therapeutic challenge due to its varied symptomatology, which often includes orthostatic headaches, nausea, and neurological deficits. Recent advancements in dynamic myelographic techniques have significantly improved the ability to identify spinal dural leaks, a key causative factor in SIH.
 
This presentation will provide an in-depth review of the clinical manifestations of SIH, emphasizing the importance of accurate and timely diagnosis. We will explore modern dynamic myelographic techniques, including digital subtraction myelography and dynamic CT myelography, which have enhanced the detection of dural breaches and spinal cerebrospinal fluid (CSF) leaks.
 
The technical aspects of performing dynamic myelography will be discussed, highlighting the procedural steps and imaging protocols that optimize the identification of dural leaks. Comparative data will be presented to illustrate the superiority of these dynamic techniques over traditional imaging methods, particularly in terms of diagnostic accuracy and the ability to pinpoint the exact location of CSF leaks.
 
Additionally, the presentation will address the implications of these diagnostic advancements for neurosurgery. Identifying spinal dural leaks early can significantly impact the management and outcomes of patients with SIH. The role of neurosurgeons in the surgical repair of these leaks, as well as the potential benefits of minimally invasive techniques, will be explored.
 
We will also discuss the critical need for healthcare professionals to recognize potential SIH patients and refer them promptly for advanced imaging investigations. Early identification and intervention can prevent chronic disability and improve quality of life for affected individuals.
 
This presentation aims to provide a comprehensive overview of the role of dynamic myelographic techniques in the diagnosis and management of SIH, offering valuable insights for neurosurgeons, radiologists, and clinicians involved in the care of patients with this condition.
BRACHIAL PLEXOPATHY DUE TO THE ONCOLOGICAL RADIATION TREATMENT RELATED TO MALIGNANCY?
Authors: Savić Andrija , Lepić Milan , Mićić Aleksa , Grujić Jovan , Rasulić Lukas
Published: November 2024

Radiation-induced brachial plexopathy is a rare but well-known late complication of radiotherapy, typically manifesting several years after treatment. While its incidence is low, it is becoming more prevalent due to improved long-term cancer survival rates, predominantly affecting females. This condition is devastating, significantly altering the quality of life, as it often results in chronic disability that is progressive and usually irreversible. This study aims to present a 38-year single centre experience in the surgical treatment of radiation-induced brachial plexopathy.
 
The study involved 92 female patients referred for potential surgical treatment of radiation-induced brachial plexopathy. Surgical candidates typically experienced progressive worsening of symptoms 4-6 months after onset, despite exhaustive conservative treatment. Diagnostic criteria included evident fibrosis on MRI or ultrasound and confirmation of plexopathy through electromyography. In total 37 patients were included, all females. Out of 92 cases, 37 were surgically treated due to plexopathy, all underwent external neurolysis, with 25 treated infraclavicularly and 12 both infraclavicular and supraclavicular. The overall functional recovery following surgery was useful, with a median outcome of M3. Post-surgery, 25 patients reported weakness, 31 experienced pain, 5 had lymphedema, and 23 had improved range of motion.
 
Successfully treating patients with radiation-induced brachial plexopathy poses a significant challenge due to the progressive and often irreversible nature of the condition. Despite surgical interventions, achieving meaningful functional recovery is complex, with many patients continuing to experience persistent symptoms such as weakness and pain.
THE LONG-TERM SEQUELAE OF TBI IN SURGICAL AND NONSURGICAL CASES
Authors: Steudel Wolf-Ingo , Rickels E. , Repschläger U. , Schulte C. , Weissgärber H. , Wende D.
Published: November 2024

Background
The acute effects of traumatic brain Injury (TBI) are well documented but there is no systematic quantification of its long-term sequelae in German-language literature. The purpose of this study is to compare the frequency of conditions linked to prior TBI with their frequency in the non-brain-injured population.
 
Methods
A matched cohort study was carried out on the basis of routine data from the BARMER statutory health insurance carrier. The exposure group consisted of patients treated over the period 2006-2009 for TBI at a variety treatment intensities. The control group consisted of BARMER insurees without prior TBI who were matched with the patients in the exposure group for age, sex, and preexisting diseases. Late sequelae were sought in the routine data for a period of ten years after the injury. The outcome rates of the exposure and control groups were compared with Kaplan-Meier estimators and Poisson regression.
 
 
Results
114,296 persons with TBI in the period of 2006-2009 were included. The mortality within ten years of TBI was 305 per 1000 individuals. The relative mortality in the exposure group was higher than that in control individuals of the same age and sex, with an incidence rate ratio (IRR) of 1,67 (95% confidence interval (1.60;1.74). Immobility, dementia, epilepsy, endocrine disorders, functional disorders, depression, anxiety, cognitive deficits, headache, and sleep disorders were also more common in the exposure group. Person with TBI requiring high-intensity treatment including surgery displayed the highest relative incidence rates of the conditions studied over 10 years of follow-up.
 
Conclusion
Adverse sequelae of TBI can still be seen ten years after the exposure. These patients die earlier than person without TBI and suffer earlier and more frequently from associated conditions.
RISK FACTORS ASSOCIATED WITH STEREOTACTIC RADIOSURGERY FOR LARGE SKULL BASE BENIGN MENINGIOMAS
Authors: Stoica Fery , Perin Radu , Neamtu Daniela
Published: November 2024

Purpose
Skull base meningiomas represent a very challenging pathology due to relatively difficult surgical access. In contrast, stereotactic radiosurgery (SRS) proved to be an effective and more secure treatment technique based on the greater accuracy in delivering precise focused radiation into the target, sparing at the same time healthy surrounding tissues.
 
Methods and Results
Our study, based on almost 20 years of experience in delivering SRS treatments using various models of Leksell Gamma-Knife units, reports a high tumor control rate for complex-shaped skull base meningiomas close to critical structures. We retrospectively evaluated the risk factors and complications after high-dose irradiation in patients undergoing single-fraction radiosurgery combined with clinical imaging criteria established using MRI scans (in T1 weighted imaging with gadolinium and the edema in T2 weighted sequences).
 
The mean volume of the tumors was 18.6 cubic centimetres (only tumors with a volume in excess of 15 cubic centimetres were included in the study). The median administered marginal dose was 12.5 Gy. Mean imaging follow-up was 112 months. Tumor control rate was not influenced by sex, age, tumor site, neurological status of the patient or irradiated volume, even though larger meningiomas are associated with poor long-term local control in most published series.
 
The long-term follow-up data indicates tumor control in 88,5% of patients after 10 years, with low incidence of complications.
 
Conclusions
Current practice shows a slight potential increase in the incidence of meningiomas, the superiority of the individual techniques needing to be confirmed in prospective and methodologically rigorous studies with at least 20 years of follow-up.
NEUROSURGICAL PERSPECTIVE ON NON-FUNCTIONING PITUITARY NEUROENDOCRINE TUMORS MANAGEMENT
Authors: Tataranu Ligia Gabriela , Ciubotaru Vasile , Solomon Adriana , Dricu Anica , Kamel Amira
Published: November 2024

Introduction
Pituitary Neuroendocrine Tumors (PitNETs), formerly designated as „pituitary adenomas” (PA), represent a relatively common pathology in the neurosurgical field, accounting for approximately 5.1 cases per 100,000 population yearly. The term “non-functioning” defines all PitNETs that do not induce a hormonal syndrome, and they account for up to 30%. Notwithstanding many aspects regarding non-functional PitNETs that are controversial, like the management of remnants or recurrences, the neurosurgical approach is indisputably indicated in cases of tumoral syndrome.
 
Material and Methods
The authors of this study aimed to assess patients presenting with non-functioning PitNETs and their outcomes after surgery in the 3rd Neurosurgical Department of the Clinical Emergency Hospital “Bagdasar-Arseni”, Bucharest, for a period of 8 years, between 2016 and 2023. This study is based on a thorough appraisal of the patient’s demographic and clinicopathological data while focusing on the strategic role of the neurosurgical approach.
 
Results
A total of 325 patients were identified with non-functioning PitNETs, that were treated in our department between the 1st of January 2016 and the 31st of March 2024, of which 193 (59.38%) were male and 132 (40.61%) were female. The mean age at admission was 50.70 years in the male group and 53.44 years in the female group, and the clinical manifestations were mostly those related to the tumoral mass effect, while more than half of the patients also presented with hypopituitarism. All of the patients included in this study underwent neurosurgery via a transnasal trans-sphenoidal approach and a gross-total resection was performed in 79% of cases (N=257). Surgical complications were described. Gamma-knife surgery was a postoperative neurosurgical option for 33 cases (48.5% of the patients with tumor remnants).
 
Conclusion
Non-functioning PitNETs usually have a slow development, which allows them to grow until the mass effect syndrome sends the patients to the doctor. Trans-sphenoidal surgery is greatly effective in providing symptomatic relief and if grosstotal resection is performed, the chances of recurrence are smaller. However, the intervention should be performed by a neurosurgeon with extensive experience in trans-sphenoidal surgery, to raise the odds of success and minimize the risks of complications.
RETROSPECTIVE STUDY OF THE SURGICAL RESULTS IN VESTIBULAR SCHWANNOMA
Authors: Zapuhlih Grigore
Published: November 2024

Introduction
Vestibular schwannoma- benign intracranial tumor of the vestibulocochlear nerve. It rise from Schwann cells sheathof the vestibular portion of vestibulocochlear nerve. Most frequently form the inferior vestibular nerve. In less than 5 % of cases it starts growing from cochlear nerve.
 
Aim of Study
To establish the incidence of acoustic neuroma development, and to establish the tactics and intraoperative approach.
 
Methods and Materials
Retrospective study was conducted that included 65 patients with acoustic neuroma who were treated surgically, through the retrosigmoid approach, in two departments of Neurosurgery in the Republic of Moldova.
 
Results
The study included a group of 65 patients, who were analyzed according to different criteria. One of the basic objectives was the presence of the neurinoma according to sexthus it was found that women are more prone to develop acoustic neurinoma compared to men. Another research criterion was the living environment of the patients, thus it was found that people from the urban environment have a higher risk of developing this pathology Analyzing the study, we also proposed an objective to analyze the average prevalence of neurinomas, so people between 51-60 years of age constituted the largest part of the group. Another aim of the research was to analyze the presence of pain in these patients and what were the most frequent complaints, so headache is the main symptom, followed by sensorineuralhearing, cofosis and tinnitus, followed by paralysis of the facial nerve, vertigo and cerebellar ataxia. After evaluating the preoperative aspects, we also analyzed the post-operative condition of the patientsthus, most of the group of patients presented paralysis of the facial nerve, followed by cerebellar syndrome and bulbar syndrome.
 
Conclusion
Mostly unilateral sensorineural hearing loss and cophosis were the first complaints of the patients. All patients with unclear, alternating unilateral sensorineural hearing loss that does not respond to specific conservative treatment are suspected to have an acoustic neuroma that can be definitely diagnosed only by the MR with contrast. Surgical treatment approach depends on tumor size, localization and extent of the tumor and its symptomatology.
العلاقة بين العدالة التنظيمية وبعض المتغيرات التنظيمية والديموغرافية في الأجهزة الحكومية في دولة الكويت
Authors: الفضلي فضل صباح , العنزي عوض خلف
Published: November 2024

تسعى هذه الدراسة إلى التعرف إلى مستويات مجموعة من المتغيرات التنظيمية (اهتمام القيادة بالعاملين، والثقة بالقيادة، والعدالة التنظيمية بشقيها الإجرائي والتعاملي). كما تسعى الدراسة إلى التحقق من طبيعة العلاقة بين متغير العدالة التنظيمية ومجموعة من المتغيرات الشخصية والتنظيمية (الجنس، والمؤهل العلمي، وسنوات الخدمة، واهتمام القيادة بالعاملين، والثقة بالإدارة)، وذلك وسط قطاع الإدارة الحكومية في دولة الكويت. وتشكلت عينة الدراسة من (۱۸۲) موظفاً وموظفة، يعملون في ست جهات حكومية كويتية تخضع كلها لقانون الخدمة المدنية، وقد اسفرت هذه الدراسة عن مجموعة من النتائج، وأهمها: انخفاض مستويات اعتراف العاملين الذكور باهتمام القيادة، إضافة إلى انخفاض مستويات ثقة العاملين الذكور بالإدارة أو القيادة مقارنة بالإناث العاملات وانخفاض إحساس العاملين الذكور بالعدالة التنظيمية مقارنة بإحساس العاملات الإناث. ووجود علاقة عكسية واضحة ما بين المؤهل العلمي، ومدة الخبرة، وإحساس الفرد بالعدالة التنظيمية. كما يلعب متغيري الثقة بالقيادة، واهتمام القيادة بالعاملين الدور الأساسي على مستوى التأثير بمستويات إحساس العاملين بالعدالة التنظيمية وسط بيئة عينة الدراسة. وتتأثر العدالة الإجرائية باهتمام القيادة بالعاملين، مقابل تأثر عدالة التعامل بالثقة بالقيادة بالدرجة الأولى.
تحويلات العمال المهاجرين وصناعة السياسة الاقتصادية الكلية في الأردن
Authors: السقا محمد إبراهيم
Published: November 2024

تهدف هذه الدراسة إلى تقييم أثر المتغيرات المرتبطة بالسياسة الاقتصادية الكلية على تدفق تحويلات المهاجرين إلى الأردن. وقد توصلت الدراسة إلى أن التحويلات تعد أهم مصادر النقد الأجنبي؛ إذ مثلت حوالي 110% من الصادرات، و 36.7% من الواردات، و 19% من الناتج المحلي الإجمالي في المتوسط خلال فترة الدراسة، وهو ما يجعل الأردن أحد أكثر دول العالم اعتماداً على تدفقات التحويلات. وقد أشارت نتائج الدراسة إلى أن هناك أثراً معنوياًّ موجباً لمستويات الدخل في الأردن على تدفق التحويلات، بينما تبين وجود أثر معنوي سالب لفروق معدلات الفائدة بين الأردن والعالم الخارجي، وانحراف معدل صرف الدينار الأردني عن مستوياته الحقيقية على تدفق التحويلات. أما أهم نتائج الدراسة فهي أن العمال المهاجرين ترتفع درجة حساسيتهم لحالات سوء صناعة السياسة الاقتصادية في الأردن. وتتمثل أهم توصيات الدراسة في ضرورة الاهتمام بفروق معدلات الفائدة و مستويات معدل الصرف، وتصميم سياسات نقدية ومالية متسقة لكي تعظم تدفق التحويلات نحو القنوات الرسمية في الأردن.
Change-oriented Leadership in the Context of Transitioning to Strategic Autonomy
Authors: Diakova Anastasia , Bagrationi Konstantin , Gordienko Olga
Published: November 2024

Growing geopolitical tensions have transformed the business landscape , driving domestic firms toward an era of strategic independence (Yale School of Management, 2024). This research examines a well-known Eastern European consulting firm that, after transitioning to an independent entity, was confronted with a new personnel assessment system. This shift necessitates a comprehensive understanding of employee readiness and resistance — fundamental concepts in change management literature (Armenakis et al., 1993). Our study incorporated quantitative methods to divide employees according to their readiness for the new system (k-means clustering, factor analysis, and discriminant analysis). At the same time, it employed qualitative research methods to explore motives and attitudes behind employee resistance or readiness (Choi & Ruona, 2011). Based on their adaptability to the new system, we identified three distinct clusters of employees: “Active Supporters,” “Cautious Appraisers,” and “Conservative Skeptics,” allowing us to pinpoint specific non-readiness factors and formulate tailored strategies to address them. The findings suggest that emotional involvement, openness to change, and previous experiences with similar practices significantly influence employee readiness. To mitigate these issues, the paper proposes a strategy rooted in psychological safety and differentiated error management, as advocated by Edmondson (2023), to enhance the organization's learning capability and adaptability. Our results align with previous research indicating that stronger attitudes, often based on personal experience, significantly predict behavior (Eagly & Chaiken, 1993). We found that the initial uncertainty of organizational changes served as a major stressor, underscoring the importance of understanding and conceptualizing changes (Kramer, 2015). Unlike Schwartz (1994), the value orientation of “Tradition” did not exert significant influence, but values of “Autonomy,” “Stimulation,” “Achievement” (consistent with Sortheix & Lönnqvist, 2014), “Hedonism,” and “Power” positively impacted employee openness to changes. The implications of this study extend to other Eastern European companies undergoing similar transitions, providing guidance on how change can be managed effectively in the context of transitioning to strategic autonomy.
Gen Z’s Digital Literacy in the Development of Proactive Personality: An HR Management Perspective
Authors: Okręglicka Małgorzata , Lemańska-Majdzik Anna
Published: November 2024

The digital literacy is required for the efficient functioning of an individual in the digital world. Digital transformation changes people's attitudes and behaviors, strengthening or weakening some of them. The continuous research in this field is justified by the fundamental changes that digitalization is bringing about in the global labor market, professional activities, and work structures. An interesting question is whether digital skills can be helpful in shaping specific attitudes and behaviors of employees as e.g. proactivity. The concept of proactivity is an important phenomenon considered within the framework of corporate entrepreneurship. A proactive organization focuses on seizing opportunities in a competitive market, implementing innovations in practice and managing market expectations. For an organization to be proactive, it is necessary to implement proactivity at all levels of the organizational structure, which may be more effective if we employ employees with a high level of proactive personality. It remains unknown whether digitization is connected with an individual's proactivity. The current study aims to examine the dependency between elements of the digital literacy and the development of proactive personality of young individuals of Gen Z, an attitude that may to emphasize the importance of proactiveness as a desirable feature in the professional life. The research was conducted in the form of a survey using the CAWI method among 370 individuals of Gen Z in Poland in 2024. Regression analysis confirmed a statistically significant dependency between the digital literacy and the proactive personality in the studied group of respondents, however, not all predictors within the model have a positive dependency with the proactive personality. The main limitations of the study are visible in not fully representativeness of the research group, and hence the inability to generalize the conclusions and make certain assumptions regarding the probable use of a proactive personality in the workplace.
Economic Resilience: Fiscal Policy, Tourism, and ICT in COVID-19
Authors: Conceição Castro  , Teresa Dieguez
Published: November 2024

The COVID-19 pandemic crisis has brought about unprecedented economic and social consequences worldwide. The implementation of isolation measures, including national and international travel restrictions, significantly affected contact-intensive sectors such as tourism. Information and Communication Technology (ICT) was crucial during this lockdown period in maintaining connectivity and enabling remote activities. Governments worldwide implemented discretionary measures to mitigate the crisis's adverse effects on economic activity. This paper aims to analyse whether the level of ICT adoption and the importance of tourism influence the fiscal policy efforts pursued by governments. Based on the results of a linear regression analysis for 154 countries, the findings suggest that governments had to promote higher fiscal stimulus in countries with higher international tourism receipts. At the same time, ICT development diminished the efforts of the fiscal policy response to the crisis since it facilitated economic resilience. The findings of this study can contribute to understanding how governments responded to the pandemic crisis and the factors that influenced their fiscal policy decisions.
The impact of green bond for achieving sustainable development goals
Authors: Wyszkowska Dorota , Filipiak Beata Zofia
Published: November 2024

The aim of this article paper is to try to establish whether or not there is a relationship between the issuance of green bonds and the achievement of selected SDG goals. Achieving such a goal required: (1). Defining green bonds - presenting the problem of recognition classification against the backdrop of legal regulations, (2). Determine the scale of green bond issuance and funding directions (3). Assess the impact of green bond issuance on the achievement of selected Sustainable Development Goals (SDGs). In particular, Pearson correlation coefficients, multidimensional scaling and linear ordering results for metric data were used. In the first step, multidimensional scaling is used to visualise objects in two-dimensional space. The study confirmed the link between the SDG goals – goal 7 (7.2.1.) related to energy and the green bond market. It also showed that market size matters for achieving the SDG goals.
К ВОПРОСУ О ЗАКРЕПЛЕНИИ ЗАКОНОДАТЕЛЬНОЙ НОРМЫ ДОБРОВОЛЬНОГО СКРИНИНГА НА ОПРЕДЕЛЕНИЕ ПСИХОАКТИВНЫХ ВЕЩЕСТВ В БИОЛОГИЧЕСКИХ СРЕДАХ
Authors: С.А. Алтынбеков , Г.И. Алтынбекова , Г.А. Садвакасова
Published: November 2024

В статье затронута актуальная проблема скрининга на определение психоактивных веществ в биологических средах в контексте эффективной борьбы с наркоманией и наркобизнесом. Проведен анализ ведомственных и других нормативно-правовых актов, в которых возможно закрепление данной нормы. Рассмотрены различные целевые группы лиц, которые могут подлежать данному скринингу; в том числе лица, проходящие предсменные (предрейсовые) обязательные и послесменные (послерейсовые) медицинские осмотры, а также силовые структуры, армия и другие государственные военные структуры. Рассмотрены преимущества и недостатки экспресс-тестирование биологических сред для определения психоактивных веществ.

The article touches upon the actual problem of screening for the determination of psychoactive substances in biological environments in the context of effective fight against drug addiction and drug trafficking. The analysis of departmental and other normative legal acts, in which it is possible to consolidate this norm, is carried out. Various target groups of persons who may be subject to this screening are considered; including persons undergoing pre-shift (pre-flight) mandatory and post-shift (post-flight) medical examinations, as well as law enforcement agencies, the army and other state military structures. The advantages and disadvantages of rapid testing of biological media for the determination of psychoactive substances are considered.

Мақалада нашақорлық пен есірткі бизнесімен тиімді күресу контекстінде биологиялық ортадағы психоактивті заттарды анықтауға арналған скринингтің өзекті мәселесі қарастырылған. Осы норманы бекітуге болатын ведомстволық және басқа да нормативтік-құқықтық актілерге талдау жүргізілді. Осы скринингке жататын адамдардың әртүрлі нысаналы топтары қаралды; оның ішінде ауысым алдындағы (рейс алдындағы) міндетті және ауысымнан кейінгі (рейстен кейінгі) медициналық тексеруден өтетін адамдар, сондай-ақ күш құрылымдары, армия және басқа да мемлекеттік әскери құрылымдар. Артықшылықтары мен кемшіліктері қарастырылады психоактивті заттарды анықтау үшін биологиялық орталарды жедел тестілеу.
MIRROR THERAPY IN THE TREATMENT OF PHANTOM PAIN. A CASE REPORT
Authors: A.A. Biniyazova , T.N. Khaibullin , N.A. Filippova , A.N. Alimkhanova , D.Sh. Zhumagali
Published: November 2024

Phantom pain is a common problem in patients with amputated limbs. It can lead to symptoms of depression for its chronicity and high intensity. It also interferes with prosthetic rehabilitation and reduces the quality of life of patients. Due to the complex pathogenesis, there is no generally accepted method of treatment for phantom pain. We present in this article the case of using mirror therapy in a University Hospital, the positive clinical result of which has been proven in multiple studies.

Фантомная боль является распространенной проблемой у пациентов с ампутированными конечностями. Она может приводить к симптомам депрессии из-за своей хронизации и высокой интенсивности. Она препятствует протезной реабилитации и снижает качество жизни пациентов. Из-за сложного патогенеза общепринятого метода лечения фантомных болей не существует. В этой статье мы приводим случай использования зеркальной терапии в университетской клинике, положительный клинический результат которой был доказан в многочисленных исследованиях.

Фантомдық ауырсыну - дене мүшесі ампутацияланған науқастарда кең таралған мәселе. Ол созылмалылығы мен жоғары қарқындылығы үшін депрессия симптомдарына әкелуі мүмкін. Протездік реабилитацияға да кедергі келтіріп, науқастардың өмір сүру сапасын төмендетеді. Патогенезі күрделі болғандықтан фантомдық ауырсынудың емінде жалпыға ортақ қабылданған әдіс жоқ. Біз бұл мақалада оң клиникалық нәтижесі көптеген зерттеулерде дәлелденген айна терапиясын университет ауруханасында қолданған жағдайды келтіреміз.
КЛИНИЧЕСКИЙ СЛУЧАЙ: НЕКЕТОТИЧЕСКАЯ ГИПЕРГЛИЦИНЕМИЯ У НОВОРОЖДЕННОГО
Authors: Н.Ә. Құрбанбеков , Н.Ж. Кусманова , Ж.М. Сембиева , Г.Н. Алимханова , М.Б. Сулейменов
Published: November 2024

Некетотическая гиперглицинемия – это редкое наследственное метаболическое заболевание, характеризующееся повышенным уровнем глицина в крови. Глицин является аминокислотой, участвующей во многих биологических процессах, и его неконтролируемое увеличение может вызвать серьезные проблемы для организма. Нами представлен уникальный клинический случай некетотической гиперглицинемии у новорожденного, возрастом всего 25 дней, в «Научном центре педиатрии и детской хирургии» города Алматы. Рассматривается сложность диагностики и лечения данного редкого наследственного заболевания, в связи с не купирующимиеся судорогами. Ранняя диагностика и лечение могут улучшить прогноз для пациентов с некетотической гиперглицинемией.

Nonketotic hyperglycinemia is a rare hereditary metabolic disease characterized by elevated blood glycine levels. Glycine is an amino acid involved in many biological processes, and its uncontrolled increase can cause serious problems for the body. We have presented a unique clinical case of nonketotic hyperglycinemia in an infant, only 25 days old, at the Scientific Center of Pediatrics and Pediatric Surgery in Almaty. The complexity of diagnosis and treatment of this rare hereditary disease due to intractable seizures is considered. Early diagnosis and treatment may improve the prognosis for patients with nonketotic hyperglycinemia.

Некетотикалық гиперглицинемия – қандағы глицин деңгейінің жоғарылауымен сипатталатын сирек кездесетін тұқым қуалайтын метаболикалық ауру. Глицин - көптеген биологиялық процестерге қатысатын амин қышқылы және оның бақыланбай көбеюі дене үшін күрделі проблемаларды тудыруы мүмкін. Біз Алматы қаласындағы Педиатрия және балалар хирургиясы ғылыми орталығында 25 күн болған нәрестедегі некетотикалық гиперглицинемияның бірегей клиникалық жағдайын ұсындық. Бұл сирек кездесетін тұқым қуалайтын аурудың емделмейтін ұстамаларға байланысты диагностикасы мен емдеуінің күрделілігі қарастырылады. Ерте диагностикалау және емдеу некетотикалық гиперглицинемиямен ауыратын науқастардың болжамын жақсартуы мүмкін.
Миф о Паганини в современных сочинениях для скрипки соло: новые техники и новые смыслы
Authors: С.Е. Ермасова
Published: November 2024

В статье рассматриваются сочинения для скрипки соло трех выдающихся современных композиторов: Сальваторе Шаррино, Альфреда Шнитке и Йорга Видмана. Каждый из авторов по-своему осмыслил легенду об одержимом скрипаче и нашел собственные пути ее актуализации; в результате, вольно или невольно, композиторы вступают между собой в диалог. Для Сальваторе Шаррино привлекательность музыки Паганини состоит в возможности услышать ее в искажении — сквозь призму новых техник, эксперименты с которыми образуют суть его «Шести каприччио» (1976). У Альфреда Шнитке в «A Paganini» (1982) за полистилистическим диалогом с музыкой прошлого актуализируется религиозно-этическая проблематика творчества. Замысел цикла шести Этюдов Йорга Видмана (1995–2010) складывался постепенно: каждое из первых трех произведений посвящено «исследованию» определенного исполнительского приема, в то время как в Этюдах IV–VI центральным становится образ Паганини. Именно эти три этюда мы трактуем как новое мифологическое пространство: Видман далеко уходит от системы координат «демоническое — божественное», в которой традиционно существовал миф о вдохновенном скрипаче. Возникают параллели с рассмотренными ранее в статье сочинениями Шаррино и Шнитке, а также с главным произведением Видмана на мифологический сюжет — оперой «Вавилон».

The article examines compositions for solo violin by three outstanding contemporary composers: Salvatore Sciarrino, Alfred Schnittke and Jörg Widmann. Each of the authors interpreted the legend of the possessed violinist in their own way and found their unique ways to actualize it; as a result, willingly or not, composers enter into dialogue with each other. For Salvatore Sciarrino, the appeal of Paganini's music lies in the ability to hear it distorted—through the prism of new techniques, experiments with which form the essence of his Six Capriccios (1976). In Alfred Schnittke’s “A Paganini” (1982), against the background of a polystylistic dialogue with the music of the past, the religious and ethical problems of creativity are actualized. The idea of the cycle of six Etudes by Jörg Widmann (1995–2010) developed gradually: each of the first three works is devoted to the “research” of a certain performing technique, while in Etudes IV–VI the image of Paganini becomes central. We interpret these three etudes as a new mythological framework: Widmann moves far away from the “demonic—divine” coordinate system in which the myth of the inspired violinist traditionally existed. Parallels arise with the works of Sciarrino and Schnittke discussed earlier in the article, as well as Widmann’s main mythological work, the opera «Babylon.»
Музыкальный диктант: между прошлым и будущим
Authors: Т.Ю. Камаева
Published: November 2024

В статье затрагиваются проблемы традиционной для отечественного сольфеджио практики — музыкального диктанта. Задуманный методологами середины прошлого века как результирующее испы­тание, призванное задействовать все полученные на уроках сольфеджио знания и умения, сейчас он не может существовать в рамках прежних установок. Эта форма работы требует критического переосмысления своего «функционала» и совершенно очевидно нуждается в корректировке самой методики преподавания. Кроме того, сегодняшние программные требования, предъявляемые к ученику музыкальной школы, не вполне соотносятся с реальностью, — изменение социальной, досуговой среды, технический прогресс напрямую отразились на навыках письма и в целом на восприятии и мышлении современного ребенка. Автор статьи анализирует данные мониторинга, проведенного в 2010–2023 годах среди педагогов образовательных учреждений культуры и искусства различных регионов России, сравнивает программы обучения прошлого и настоящего, предлагает пути преодоления сложившейся ситуации.

The article touches upon the problems of tradi­tional Russian ear-training practice―musical dic­tation. Developed by methodologists in the mid-20th cen­tury, it was intended to involve all the knowledge and skills acquired during ear training classes. However, this form of work can’t exist with the old guidelines. It requires a critical rethinking of its possibilities and needs to be revised during the learning process. Furthermore, modern program requirements for music students do not correspond with reality due to changes in social and leisure time and technological progress, which have directly affected the writing skills and the overall perception and thinking of today’s children. The article’s author analyses data from teachers’ monitoring at Russian arts and cultural education institutions, which took place between 2010 and 2023, compares past and current educational programs, and suggests ways to resolve the current situation.
Музыкальный диктант — как ракета: взлетит, если грамотно собраны все узлы
Authors: М.В. Карасева
Published: November 2024

Статья посвящена вопросам развития музыкального слуха на уроках сольфеджио в му­зыкальной школе. Ее центральной темой является роль музыкального диктанта не только как формы работы на уроке, но и как способа выработки индивидуальной стратегии освоения учеником ритмоинтонационного материала. Рассмотрены методические приемы, применяемые в отечественной педагогической практике с конца XIX века до наших дней. Автор отмечает историческую преемственность наиболее эффективных из них и доказывает необходимость их применения в работе над музыкальным диктантом сегодня. Дана классификация видов музыкального диктанта и представлены варианты пошаговых музыкально-слуховых и психологических стратегий в его написании. Определена специфика и обоснована целесообразность использования на уроке таких основных видов диктанта, как инструктивный и художественный. Приведены примеры уместного применения цифровых технологий в процессе работы над музыкальным диктантом.

The article is devoted to ear training in a music school. The article’s central theme is the role of music dictation not only as a form of work in the classroom but also as a way to develop an individual strategy for the student to master rhythmic and intonation material. Characteristic methodological techniques in the Russian solfeggio school from the end of the 19th century to the present, are identified and discussed. On this basis, the need for continuity of the most effective methods of ear training which are partly lost at present, is shown. A classification of types of music dictation is given and examples of step-by-step musical-auditory and psychological strategies for preparing for its writing are presented. The methodological specifics and level of feasibility of using instructional and artistic dictations (taken from musical literature) have been determined. Examples of the appropriate use of digital technologies in working on a musical dictation are given.
Bishop Iacob Antonovici. His Life and Ecclesiastic Activity
Authors: Pascaru Costel-Eugen
Published: November 2024

The paper is a short, but well documented biography of Iacob Antonovici, an important prelate of the Romanian Orthodox Church in early 20th century. The author insists on Antonovici’s formative years as a priest, but also as a man of letters, teacher and devoted historian. His ecclesiastic and cultural activity in Bârlad and Huşi made his a respected member of the religious hierarchy, so he was elected archbishop of the “Dunărea de Jos” see and then moved to the bishopric of Huşi. His historical and cultural activity secured his nomination as an honorary fellow of the Romanian Academy, as well as of several other scientific associations.
Aspects of Daily Life in Brăila during the German Occupation in the First World War (1916 – 1918)
Authors: Urse Antonel
Published: November 2024

In December 1916, when the defeated Romanian army and the authorities in Bucharest retreated to Moldavia, Brăila was occupied by the troops of the Central Powers. For two years, the city was administered by German officers, who tried to integrate all local resources into the war effort of the Central Powers. The paper presents, on the basis of unpublished sources from local archives, several aspects related to the administration of the city, the rationalisation of food supplies, the confiscation of private property, etc.
The Monarchy and the city of Barlad
Authors: Proca Marcel
Published: November 2024

Throughout its history, the town of Barlad was visited repeatedly by Romanian monarchs. Carol I was the one who visited it the most, both during his travels throughout the entire country and due to some military operations in the region. King Ferdinand I set his residence in the Royal Quarters on the Slobozia - Zorleni domain when he took refuge (from December 1916 to January 1917).
Rome and Carthage, 279/278 – 264 BC
Authors: Nedu Decebal
Published: November 2024

Between the 6th and the 3rd centuries BC, Rome and Carthage defined their political and commercial relations through a series of agreements. "The Philinus treaty" signed in 306 BC and the agreement agreed upon in 279/278 BC revealed the existing tensions and suspicions between the two states at the end of the 6th century BC and in the first decades of the 3rd century BC. The treaties established Italy as an exclusively Roman sphere of influence and Sicily as an area subjected to Carthaginian interests, where the Romans were not allowed to intervene. After King Pyrrhus had left Italy in 275 BC, both Rome and Carthage took into account a possible Roman-Punic war. The existing tensions and suspicions grew in intensity in 272 BC when a Carthaginian fleet appeared in the harbour of Tarentum while the Roman legions were besieging the city. In order to prevent a possible war, the Romans urged the pacification of the southern peninsula and rushed to include the Greek cities of southern Italy in the Roman treaties network. Therefore, having to face the most powerful fleet in the Western Mediterranean, in 267 BC the Roman Republic established four quaestores classici with the mission to reorganize the existing naval forces in the Italic Peninsula.
A General Overview of Romanian Research on the Gagaouz People
Authors: Mehmet Mustafa
Published: November 2024

Based upon an extended bibliographical list that contains many works on ethnogenesis, language, folklore, culture and inter-ethnical relations, the article wishes to offer an overview of Gagaouz origins and history, as they are reflected through Romanian researchers’ writings.
A IMPORTÂNCIA DA AUDITORIA EXTERNA PARA AS COMPANHIAS ABERTAS S/A
Authors: Costa do Carmo Leonardo
Published: November 2024

In Brazil, there are laws that regulate private accounting, among which Law 6,404/76 stands out, which makes it mandatory for publicly held companies to be audited. Furthermore, this law sets out everything that a public entity needs to be accounted for. In this context, it can be highlighted that this work will address this standard on this aspect, as well as highlighting the importance of Auditing for external agents to make decisions about the company, emphasizing the fundamental role of the Auditor in applying their knowledge to issue an opinion on the financial statements. Therefore, the accounting opinion is fundamental for the company, as it helps its relationship with stackholders.
TRANSPORTE AQUAVIÁRIO: AVALIAÇÃO DE UMA NOVA ALTERNATIVA DE MOBILIDADE INTERURBANA PALMAS-TO/PORTO NACIONAL-TO
Authors: NUNES BEQUIMAM LUCAS , Coelho e Silva Rodrigo , Aviz Palma e Silva Arthur , Nunes Vaz Leonardo , Mascarenhas Negreiros Eduardo , Soares Queiroz Priscila
Published: November 2024

Waterway transportation between Palmas and Porto Nacional on the Tocantins River is a promising alternative to foster regional development. This study aims to assess the feasibility of a waterway transportation system connecting these two cities, highlighting benefits such as reduced dependence on road transportation, logistical efficiency, economic development, and tourism potential. The research employed a quantitative approach through questionnaires administered to residents of both cities to capture perceptions of current mobility and acceptance of the new mode. Results indicate a strong public acceptance of waterway transportation (78.4%) and a perception that the accessibility, mobility, and infrastructure of the current road transport system are limited, underscoring the positive potential impact of implementing a waterway system.
Clinical and population analysis of the demand for orthopedic treatment with removable dentures among the residents of Kharkiv and the Kharkiv region
Authors: Kulish S.A.
Published: November 2024

The goal of this research was to assess the demand for orthopedic treatment with removable dentures among the residents of Kharkiv and the Kharkiv region by conducting a clinical and population analysis of the orthopedic treatment outcomes for dental patients who sought such treatment. The study was based on data from outpatient individual medical cases (medical do­cuments’ form 043/0) from 10 healthcare facilities in Kharkiv and the Kharkiv region over the period from 2019 to 2022. During this period, a total of 68,391 dentures were manufactured, with 75 orthopedic dentists and 103 dental technicians involved in the treatment process. The research focused on identifying both quantitative and percentage indicators of the demand for removable dentures among all manufactured dentures. Additionally, the distribution of different types of removable prosthetic structures was analyzed within the total number of dentures produced, as well as among the subset of removable dentures. Indicators were also calculated for the demand for removable dentures among the entire population that sought orthopedic treatment, allowing for an estimation of the representative demand for removable dentures across the Kharkiv region from 2019 to 2022. The consistently high demand for removable dentures highlights the importance of this type of treatment in the region and underscores the need for ongoing advancements in dental materials, methods, and technologies used for these prosthetic solutions. Such findings are crucial for healthcare providers and policymakers to address the growing needs of the population, particularly as aging demographics contribute to an increased requirement for durable and comfortable dental prosthetics. Future research aims to explore the development of acrylic-free plastic for the bases of removable dentures, which could enhance patient comfort and reduce allergic reactions, thereby improving the quality of orthopedic dental care.

Keywords: dental morbidity, orthopaedic care, removable prosthesis designs, outpatient card.