bluuebunny/crossref_metadata_2025 huggingface dataset:
KAJIAN KONSEP ARSITEKTUR KONTEMPORER PADA BANGUNAN PENDIDIKAN P.K. OJONG-JAKOB OETAMA TOWER
Authors: Zulfa Azka Raihan , Afgani Jundi Jundullah
Published: May 2024

ABSTRAK. Ilmu merupakan sebuah kunci akan segala kebaikan serta pengetahuan. Ilmu menjadi sebuah sarana untuk bisa menjalankan hidup ini dan apa yang menjadi perintah Allah SWT kepada kita. Dalam perkembangannya pembangunan bangunan pendidikan sangat penting untuk menciptakan suasana belajar yang nyaman dan bermanfaat bagi pengguna, sekaligus sebagai penanda bahwa pendidikan tidak hanya berkembang pada sistem saja akan tetatapi juga dengan pembangunan penunjang fasilitas yang berkualitas dan menjadi citra yang baik untuk pendidikan Indonesia. Kajian ini bertujuan lebih memehami konsep kontemporer terhadap prinsip dan penerapan pada bangunan pendidikan lebih tepatnya universitas dengan rumusan masalah Bagaimana bangunan pendidikan dalam studi kasus dikatakan menerapkan konsep arsitektur kontemporer?. Metode yang digunakan dalam kajian ini adalah kulaitatif dengan pendekatan deskriptif pada studi kasus bangunan kontemporer pada bangunan pendidikan lebih tepatnya universitas. Hasil dari kajian ini menunjukan bahwa konsep kontemporer memiliki prinsip tersendiri dari segi bentuk yang dinamis, kompleks, dan bentuk pengulangan dan simetri. Kajian ini diharapkan dapat digunakan sebagai awal pengembangan desain dalam rancangan arsitektur kontemporer. Kata Kunci: Konsep Kontemporer, Bangunan Pendidikan, Arsitektur ABSTRACT. Science is the key to all goodness and knowledge. Science becomes a means to be able to live this life and what Allah Almighty commands us. In its development, the construction of educational buildings is very important to create a comfortable and useful learning atmosphere for users, as well as a sign that education will not only develop in the system, but also with the construction of supporting quality facilities and become a good image for Indonesian education. This study aims to better understand the contemporary concept of principles and application to educational buildings, more precisely universities with the formulation of the problem How is educational building in case studies said to apply the concept of contemporary architecture?. The method used in this study is quantifiable with a descriptive approach to case studies of contemporary buildings in educational buildings, more precisely universities. The results of this study show that contemporary concepts have their own principles in terms of dynamic, complex shapes, and forms of repetition and symmetry. This study is expected to be used as a prelude to design development in contemporary architectural design. Keywords: Contemporary Concepts, Educational Buildings, Architecture
Anthroposophie und Nationalsozialismus. Weleda und WALA – die anthroposophischen Arzneimittelfirmen 1933–1945
Authors: Selg Peter , Gross Susanne H. , Mochner Matthias
Published: May 2024

Wie verhielten sich Weleda und WALA gegenüber dem Regime des Nationalsozialismus? Wie hoch war der Preis, den die beiden Firmen für ihr Überleben zahlten? Der Band stellt erstmals die Geschichte der mittlerweile weltweit tätigen anthroposophischen Pharmazie- und Kosmetikunternehmen zwischen 1933 und 1945 dar. Im ersten Teil geht es um die Reaktion der Weleda auf die politische Bedrohung im Spannungsfeld zwischen Anpassung und Resistenz sowie die Auseinandersetzungen mit Ministerien und Parteistellen. Aufgezeigt werden auch ihr Bemühen um kriegswichtige Aufträge sowie die Kontakte zur DVA in Dachau. Der zweite Teil widmet sich Rudolf Hauschkas Laborgründungen, seiner Tätigkeit in den Gnadenwalder Kuranstalten sowie seinen Kontakten zu einigen hochrangigen Vertretern des Regimes. Auch seine Inhaftierung, seine Vitaminforschung, Elixierproduktion und seine Tätigkeit im homöopathischen Krankenhaus Höllriegelskreuth werden thematisiert.
Unusual presentation of acute psychosis in a child
Authors: Busari Olubunmi , Naeem Moin , Govindarajan Sandhya , Zamir Imran
Published: May 2024

Background:

Psychosis is often solely described as a psychiatric presentation; however, it is vital that organic causes are eliminated, especially in children.

Case presentation:

We report the case of a 14-year-old girl who presented a 2-month history of self-neglect, poor school performance, and a week history of mutism. At initial presentation, her neurological examination was normal except for expressive aphasia, and occasional inappropriate laughing. First-line investigations showed low vitamin B12 and folate and normal magnetic resonance imaging. She was planned for follow up with psychiatrists.

She presented about a week later with worsening symptoms. She had further investigations which revealed high homocysteine, in keeping with homocysteine remethylation disorder. She was started on betaine therapy after which she had a significant improvement in her symptoms.

Conclusion:

This case emphasizes the importance of thorough investigations of children with acute psychosis before making an assumption of a psychiatric cause, as reversible causes have better outcomes.
Challenging Neurological Manifestations in Large-Cell Neuroendocrine Carcinoma (LCNEC): A Case Study of Extensive Intracranial and Intradural Metastases
Authors: Mahler Julia , Halatsch Marc-Eric , Alfieri Alex
Published: May 2024

This case study explores the challenging neurological manifestations in a 59-year-old female diagnosed with large-cell neuroendocrine carcinoma (LCNEC). The patient initially presented with aphasia, which led to the discovery of an intracranial cystic-necrotic metastasis. Despite surgical and aggressive radio-chemotherapy treatments, her condition progressed to extensive leptomeningeal carcinomatosis (LMC) and intradural spinal metastases. This resulted in right dominant paraparesis, saddle hypesthesia, and urinary incontinence, developing into paraplegia even after emergency radiotherapy of the complete spine. The unprecedented extent of LCNEC metastases in both intracranial and intraspinal regions raises important considerations for diagnostic assessment in neuroendocrine tumors with neurological symptoms. Despite aggressive intervention, the prognosis remains poor, emphasizing the challenges in managing advanced LCNEC stages with widespread metastases.
Una propuesta de análisis sistémico para la selección de tecnologías para remediación de suelos a partir de un análisis multicriterio
Authors: Scarpetta Molano Kevin Duvan , Villarreal Tapia Leidy
Published: May 2024

La remediación de sitios contaminados en la industria del petróleo y gas representa una tarea crítica para salvaguardar el medio ambiente y la salud pública. La selección precisa de tecnologías de remediación resulta fundamental para alcanzar resultados eficientes y sostenibles. En este artículo, se propone un enfoque de análisis sistémico para la selección de tecnologías de remediación de suelos, mediante la aplicación de un marco de análisis multicriterio basado en el Proceso Jerárquico Analítico (AHP). Este método considera diversos factores, como la naturaleza de los contaminantes, condiciones específicas de desplazamiento, el impacto ambiental, la viabilidad económica y la aceptación social. Al integrar estos criterios, los responsables pueden tomar decisiones fundamentadas y exhaustivas respecto a las técnicas de rehabilitación más apropiadas para sitios contaminados específicos.
Patrimônio rural e urbano em Presidente Venceslau: estudo de caso da Fazenda Santa Sofia
Authors: Mendes Vítor Hugo de Figueiredo , Barone Luis Antonio
Published: May 2024

A história do Presidente Venceslau/SP tem semelhança com a das demais cidades do Oeste Paulista, marcada pela expansão ferroviária e da cultura do café. Ali, Álvaro Antunes Coelho encarnou a figura do colonizador/grileiro que tratou de lotear a área onde se localiza o município atualmente, de modo que, este estudo do patrimônio rural e da área envoltória, hoje no coração da cidade, é revelador quanto aos agentes que escrevem a história e das vozes que se sobressaem nas disputas de narrativas. Este artigo investiga o histórico e os processos de reconhecimento social que levaram ao tombamento pelo Conselho de Defesa do Patrimônio Histórico, Arqueológico, Artístico e Turístico (CONDEPHAAT) do conjunto constituído pela Sede e Mirante da Fazenda Santa Sofia, tal como sua influência no processo de transformação e usufruto da paisagem. Para tal, realizou-se visitas a campo e, devido à pandemia do COVID-19, entrevistas online com agentes públicos e privados relacionados ao processo de tombamento e gestão do bem. Verificou-se que a especulação imobiliária ameaçava o bem, levando ao tombamento - que buscou evitar qualquer descaracterização da área. Isso, de certa forma, foi alcançado, mas tal mecanismo, sem o auxílio de agentes públicos, não é suficiente, além de verificar-se que sociedade local reconhece o objeto de estudo como componente de sua história.
Genetic Diversity and Haplogroup Distribution of Three Ethnic Groups Tay, Thai, and Nung
Authors: Duong Nguyen Thuy , Anh Nguyen Phuong , Hai Nong Van
Published: May 2024

The mitochondrial genome, with outstanding characteristics such as maternal inheritance, non-recombination and high mutation rate, is of great importance in population genetics and evolution research. To study the genetic diversity and the distribution of haplogroups of the Tai – Kadai language group, blood samples of 108 men from three ethnic groups Tay, Thai and Nung were collected. Total DNA extracted from blood samples was used for library preparation and whole mitochondrial genome sequencing using NGS. Comparing the obtained mitochondrial genome sequence with the RSRS (Reconstructed Sapiens Reference sequence) from Genbank (NC_012920) revealed 3929 distinct variants  in 108 individuals with 1663 variants in the Tay ethnic group, 905 variants in the Thai ethnic group and 1361 variants in the Nung ethnic group. Nucleotide diversity (π) and haplotype were highest in the Thai ethnic group, being 0.0023 and 0.989, respectively. The genetic distances between each ethnic group pair (Tay-Nung, Tay-Thai and Thai-Nung), as shown by the FST values, were 0.03101; 0.00447 and 0.03282, respectively. Haplogroup analysis showed that 108 studied individuals belonged to 33 different haplogroups, belonging to 2 groups of haplogroups M and N. The most frequent haplogroups in Tay Thai and Nung were B4, F1 and M7, respectively. The results of this study show that although belonging to the same Tai - Kadai language family, the mitochondrial genomes among the three ethnic groups Tay, Thai, and Nung still have notable differences.
Entrevista a Patrick Charaudeau
Authors: Escamilla Morales Julio
Published: May 2024

Resumen
Actitud del escolar frente al indígena
Authors: Jiménez Manuel
Published: May 2024

Resumen
De la práctica comunicativa convencional hacia una práctica interaccional no convencional: La sugestopedia
Authors: Jiménez Manuel
Published: May 2024

Resumen
Estudio estadístico del español
Authors: Guirao Miguelina , García Jurado María A.
Published: May 2024

Resumen
Presentación
Authors: De Escorcia Blanca A.
Published: May 2024

Resumen
Encariñado con el oficio (Entrevista)
Authors: Oviedo Tito Nelson
Published: May 2024

Resumen
Spanish Phonology (Reseña Crítica del libro de James W. Harris)
Authors: Oviedo Tito Nelson
Published: May 2024

Resumen
Emotividad y expresión lingüística en la comunicación cotidiana
Authors: Oviedo Tito Nelson
Published: May 2024

Resumen
La acción educativa: una disciplina profesional (El educador como profesional)
Authors: Oviedo A. Tito Nelson
Published: May 2024

Resumen
Lista de tesis aprobadas en los últimos diez años en la maestría de Lingüística y español de la Escuela de Ciencias del Lenguaje- Universidad del Valle
Authors: W. Harris James
Published: May 2024

Resumen
Grupos de investigación de la Escuela de Ciencias del Lenguaje
Authors: Revista Lenguaje
Published: May 2024

Resumen
Analisis Produktivitas Wheel Loader pada Finger di PT Bumi Suksesindo
Authors: Farras Abbyan , Azizi, ST, MT Dr. Masagus Ahmad , Herdyanti Mixsindo Korra , Putra Danu
Published: May 2024

Salah satu kegiatan dalam kegiatan operasi penambangan adalah kegiatan operasi produksi. Kegiatan operasi produksi ini meliputi penggalian dan material handling dari bahan galian. Untuk melakukan kegiatan operasi produksi langkah yang dilakukan adalah melakukan penggalian bahan galian setelah itu dilanjutkan dengan kegiatan material handling. Dalam kegiatan pengolahan emas di PT Bumi Suksesindo, ore yang telah diangkut dari pit selanjutnya akan di dumping ke ore processing plant untuk dilakukan kominusi (pengecilan ukuran), akan tetapi, apabila hopper penuh, ore akan ditimbun di finger yang merupakan tempat penyimpanan sementara ore yang telah diangkut. Permasalahan muncul ketika ore processing plant mengeluhkan adanya no feeding. Target produksi emas yang telah ditetapkan oleh PT Bumi Suksesindo pada bulan Juni 2022 adalah sebesar 685,26 ton/jam. Setelah dilakukan analisis didapatkan produktivitas wheel loader pada finger 4,5, dan6 adalah 977,86 ton/jam, 765,28 ton/jam, dan 586,71 ton/jam.
تقويم أداء معلمي اللغة العربية في مراكز محو الامية من وجهة نظر المشرفين ومديري المراكز.
Authors: إبراهيم عبد الرزاق جميل
Published: May 2024

رمى البحث الحالي إلى تقويم أداء معلمي اللغة العربية في مراكز محو الامية من وجهة نظر المشرفين ومديري المراكز , لذا تمثلت عينة البحث كل مشرفي  اللغة العربية لمراكز محو الامية التابعين لمديريات بغداد والبالغ عددهم  (54) مشرفا , و (135) مديراً لمراكز محو الامية العائدة إلى مديريات تربية محافظة بغداد , طبق الباحث عليهم مقياس مُكوّن من (47) فقرة موزعة على ستة محاور  هي ( مهارات التخطيط للدرس – مهارات التعليم – الالمام بالمادة العلمية - فهم المعلم لطبيعة الدارسين وحسن التعامل معهم - مهارة تقويم الدارسين – سمات الشخصية والمهنية للمعلم) .
وتوصل الباحث إلى عدة نتائج منها :-
   أن هناك جوانب في مهارات التعليم :( المحاور ) درجة ممارستها من قبل معلمي اللغة العربية عالية جدا وهي : ( محور الإلمام بالمادة العلمية ) و( محور السمات الشخصية والمهنية ) و ( فهم طبيعة الدارسين وحسن التعامل معهم ) و( محور المهارات التعليمية ) .
وتوصيات منها :-

أن يكون هناك اهتمام قسم تعليم محو الامية بمتابعة تقارير المشرفين التربويين لمادة اللغة العربية في مراكز محو الامية , وتفعيل التوصيات الواردة فيها فيما يتعلق بأداء معلمي اللغة العربية .
أن تقوم قسم تعليم محو الامية بإقامة الدورات التدريبية المكثفة والشاملة لكل ما يتعلق بتعليم الكبار , وعلى كل الأصعدة والجوانب الفنية والتقنية.

ومقترحات منها :-

تقويم أداء معلمي اللغة العربية في مراكز محو الامية في كافة فروع اللغة العربية .
تحديد الاحتياجات التدريبية لمعلمي اللغة العربية في مراكز محو الامية.
ENHANCING PEDAGOGICAL COMPETENCIES IN PRE-SERVICE TEACHERS’ THROUGH MICROTEACHING: A QUALITATIVE STUDY
Authors: Purwanti Eko , Suhargo Graciella Indrawati
Published: May 2024

Pedagogical competence is one of compulsory competencies required for teachers to perform their tasks professionally. To produce qualified teachers, many teacher training institutions provide courses that can help pre-service teachers build their pedagogical competences, such as Microteaching. However, not all pre-service teachers understand the importance of this course, and they barely take this course seriously. This research aimed to explore how Microteaching course can assist pre-service teachers build their pedagogical competences and explores its aspects that can be improved. Utilizing qualitative approach, six participants of preservice teachers of English language education department of Private University in Central Java were involved, and they were individually interviewed to collect the data. Microteaching course enables pre-service teachers build their pedagogical competences in that 1) it improves their lesson plan, 2) it provides them with teaching practice experiences, and 3) it gives opportunities for them to evaluate their teaching practices. In addition, Microteaching course enables the pre-service teachers to build their pedagogical competencies aspects, comprising 1)identifying students’ characteristics, 2) carrying out reflection, 3) understanding students’ learning, 4) developing students’ potentials, 5) building good communication skills, and 6) carrying out assessment and evaluation. As microteaching course enables pre-service teachers improve their pedagogical knowledge in many aspects, students of teacher training should take the course more seriously.
Data-Driven Nonintrusive Model-Order Reduction for Aerodynamic Design Optimization
Authors: Moni Abhijith , Yao Weigang , Malekmohamadi Hossein
Published: May 2024

Fast and accurate evaluation of aerodynamic characteristics is essential for aerodynamic design optimization because aircraft programs require many years of design and optimization. Therefore, it is imperative to develop sufficiently fast, robust, and accurate computational tools for industry routine analysis. This paper presents a nonintrusive machine-learning method for building reduced-order models (ROMs) using an autoencoder neural network architecture. An optimization framework was developed to identify the optimal solution by exploring the low-dimensional subspace generated by the trained autoencoder. To demonstrate the convergence, stability, and reliability of the ROM, a subsonic inverse design problem and a transonic drag minimization problem of the airfoil were studied and validated using two different parameterization strategies. The robustness and accuracy demonstrated by the method suggest that it is valuable in parametric studies, such as aerodynamic design and optimization, and requires only a small fraction of the cost of full-order modeling.
Low-Frequency Intensity Modulation of High-Frequency Rotor Noise
Authors: Baars Woutijn J. , Ragni Daniele
Published: May 2024

Acoustic spectra of rotor noise yield frequency distributions of energy within pressure time series. However, they are unable to reveal phase relations between different frequency components while these play a role in the fundamental understanding of low-frequency intensity modulation of higher-frequency rotor noise. A methodology to quantify interfrequency modulation is applied to a comprehensive acoustic dataset of a fixed-pitch benchmark rotor, operating at a low Reynolds number and at advance ratios ranging from [Formula: see text] to 0.61. Our findings strengthen earlier observations in case of a hovering rotor, in which the modulation of the high-frequency noise is strongest around an elevation angle of [Formula: see text] (below the rotor plane). For the nonzero advance ratios, modulation becomes dominant in the sector [Formula: see text] and is most pronounced at the highest advance ratio tested ([Formula: see text]). Intensity modulation of high-frequency noise is primarily the consequence of a far-field observer experiencing a cyclic sweep through the noise directivity pattern of relatively directive trailing-edge noise. This noise component becomes more intense with increasing [Formula: see text] and is associated with broadband features of the partially separated flow over the rotor blades.
Electrothermal Coupling Methodologies and Their Influence on the Optimization of Aircraft Electric Motors
Authors: Babcock Tucker , McKeever Bryan , Hicken Jason E.
Published: May 2024

This work presents a fully coupled electrothermal motor analysis and optimization framework, where the motor’s electromagnetic performance depends on its temperature distribution, and the temperature distribution simultaneously depends on its electromagnetic performance. Notably, we analytically compute derivatives through this nonlinear, multidisciplinary analysis using coupled adjoints, which enables the exploration of high-dimensional design spaces. We demonstrate the framework on a series of optimization problems that investigate the effect of feedback coupling and serve to highlight the framework’s utility and flexibility. Furthermore, our results indicate that modeling the motor’s electrothermal coupling is critical to accurate performance prediction. We show that designs optimized using a feedforward-coupled model are found to be either infeasible or nonoptimal under the fully coupled feedback analysis; both conditions are unacceptable for aircraft applications, in which performance is critical.
Deployment Simulation of Foldable Membranes Using Absolute Nodal Coordinate Formulation and Validation
Authors: Wang Tengfei , Wu Ziyuan , Xu Minglong , Wang Jia
Published: May 2024

It has become a trend to use foldable membranes to construct large spacecraft structures such as solar sails, antennas, and drag sails with the advantages of being lightweight and having high packing efficiency. To enhance the existing numerical simulation of membrane deployment, the nonlinear behavior of the crease is finely described based on experiments and integrated into the numerical model via the principle of virtual work. Specifically, a foldable membrane is modeled as a multibody system (MBS) based on the absolute nodal coordinate formulation (ANCF), where the flexible facet is meshed with both ANCF triangular and quadrilateral thin shell elements and the crease is treated as a virtual torsional spring with special constraints along the fold line. The MBS modeling method is validated via the deployment experiment of a Z-folding membrane. The deployment of a four-unit Miura-ori membrane is further analyzed to show the capability of the approach in modeling foldable membranes with complicated configurations. Good agreement is obtained on the membrane-deformed configurations between the simulation and experiment. Additionally, the driving force at the corners is obtained. This research is expected to provide a more accurate simulation to facilitate the design and optimization of the space deployable membrane structure.
CONCEPTION OF GENETIC CORE IN STRUCTURAL ORGANISATION AND EVOLUTION OF COMPLEX ELECTROMECHANICAL SYSTEMS
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Shynkarenko Vasyl
Published: May 2024

The interdisciplinary aspect in the study of the core concept in complex genetically organized systems of natural and anthropogenic origin is analyzed. The purpose of the article is scientific substantiation of the nature and essence of the genetic core of the electromechanical system. Based on the provisions of the theory of genetic evolution of electromechanical systems, the information essence of the genetic core as a carrier of genetic information of the primary source of the electromagnetic field is revealed. The analysis of the invariant relationships of the genetic nucleus with the structure of groups, subgroupsand small periods, the generative system was carried out. An invariant connection between the core concept and the processes of evolutionary speciation and the main taxonomic categories of electromechanical systems has been established. Based on the results of the system-genetic analysis, a definition of the concept of the genetic core is proposed. The relationship between genetic and energy cores in the hierarchy of levels of complexity of electromechanical systems is studied. The principles of genetic structuring of complex systems of themultinuclear type are revealed. According to the results of the system-genetic analysis of the conception of the genetic core of electro-mechanical systems, its main properties are summarized. The im-portance of the obtained research results for the spreadof genetic prediction technology and interdisciplinary synthesis to complex electromechanical complexes with nuclei of different physical nature is emphasized
Improving the Accountability in Pris: Key Strategies and Actions
Authors: Taqiuddin Mohd
Published: May 2024

The term ‘Accountability’ refers to the obligation of Panchayati Raj Institutions (PRIs) to answer to their constituents for their decisions and actions. It includes Financial Accountability, focusing on Financial Management, and Social Accountability, focusing on Service Delivery and responsiveness to citizens’ needs. Promoting accountability enhances transparency in Panchayat governance. This paper examines the accountability components in PRIs and discusses measures taken by the Central Finance Commission, Comptroller & Auditor General (C&AG) of India, and the Ministry of Panchayati Raj (MoPR) in the last two decades to enhance accountability in Panchayats. Key strategies and actions introduced by these authorities include the Model Accounting System, Vibrant Gram Sabha, Participatory Planning, Social Audit, Panchayat Citizen Charter, e-GramSWARAJ, and AuditOnline. The policymakers and stakeholders need to collaborate in implementing these reforms to ensure PRIs are accountable to the citizens they serve and provide effective good governance at grassroots level.
A resonance triggers chemical reactions between the coldest molecules
Authors: Park Juliana , Choi Wonyl
Published: May 2024

The rich energy structure of ultracold molecules (at -459 °F or -273 °C),  gives rise to collisional dynamics where the state-of-the-art models are inadequate for describing collisional resonances. We have discovered a pronounced magnetically tuned resonance in collisions between two NaLi molecules, which enhances the chemical reaction rate by more than a factor of a hundred.
An Emerging Era: Wearable Breast Ultrasonography at Home
Authors: Dagdeviren Canan , Ozkan Lara
Published: May 2024

Ultrasound is key for detecting breast cancer. However, current bulky, planar imaging devices do not fit the unique breast shape well. We have developed a new conformable Ultrasound Breast Patch (cUSBr-Patch), which overcomes this with a flexible transducer array, nature-inspired honeycomb patch, and accurate signal processing. This breakthrough allows breast ultrasound to become wearable, operator-independent, and more accessible.
Keeping the balance: How epigenetics monitors cancer genes
Authors: Gray Zach , Honer Madison , Whetstine Johnathan
Published: May 2024

Epigenetic regulation consists in chemical modifications on the proteins that organize DNA. Here, we show how it increases gene copies and rearranges the MLL gene, which associates with infant, adult, and therapy-associated leukemia.
These findings show how chemotherapy-induced MLL changes occur and provide a therapeutic way to prevent them.
Knowledge and attitude gap toward ear, nose, and throat foreign bodies in children among parents and teachers in Federal Capital Territory
Authors: Dahilo Enoch Auta , Yikawe Stephen Semenyakenso , Omosule Ikeoluwa Elizabeth , Folorunso David Femi
Published: May 2024

Objectives:

Ear, nose, and throat (ENT) foreign bodies (FBs) are common Otorhinolaryngological emergencies, especially among children. This study aims to assess the knowledge and attitude gap towards ENT FBs in children among parents and teachers, with a view to advocating public enlightenment on the dangers of ENT FBs in children. This study aims to assess the knowledge and attitude gap toward ENT FBs in children among parents and teachers with a view to advocating public enlightenment on the dangers of ENT FBs.

Material and Methods:

This was a cross-sectional descriptive prospective study. A multistage sampling method was used to enroll participants among the six Area Councils in the Federal Capital Territory. Participants were among parents and guardians whose children attended those schools. The instrument for data collection was a pre-tested, standardized, and semi-structured questionnaire.

Results:

Of the 270 questionnaires issued, there were only 240 responses, which consisted of 29 parents and 211 teachers. Among the teachers, there were 128 females (60.7%) and 83 males (39.3%) M: F 1:1.5. Majority of them were 30–39 years 102 (51.2%). Most of the parents were between 30 and 39 years 14 (48.3%).

Conclusion:

Awareness creation among the parents and teachers is fundamental to bridge the attitude gap in our society.
Autologous platelet-rich plasma as a potential new approach in the endometrial response during in vitro fertilization cycle: A pilot study
Authors: Bakshi Rita , Kumar Upendra , Prasad Biva , Gautam Shraddha Singh , Singh Lipi
Published: May 2024

Objectives:

Infertility is a global health concern, affecting ~13% of couples. Despite assisted reproductive technology (ART) attempts, implantation failure occurs due to inadequate growth of the endometrium. Increasing endometrial thickness (ET) can be increased to improve the rate of pregnancy; implantation necessitates a minimum thickness of 7 mm. Platelet-rich plasma (PRP) is a recommended treatment approach for endometrium and ovarian infertility. This approach minimizes the potential of immunogenic reactions and disease transmission because PRP comes from an autologous source. The purpose of this study was to evaluate the efficacy of PRP intrauterine infusions during the in vitro fertilization (IVF) cycle in patients with thin endometrium.

Material and Methods:

Ten patients with primary infertility (age: 28–40 years) were chosen for intrauterine PRP infusion at the RiSSA IVF Center, Delhi. This study was carried out between June 2020 and January 2022 over a span of 18-month period. Intrauterine infusion of PRP was an additional procedure to hormone replacement therapy (HRT) treatment cycle. PRP was prepared by centrifugation process from autologous blood. On the 10th day of HRT cycle, 2 mL of PRP was infused into the uterine cavity. In each cycle, PRP infusion was administered 1–3 times if there was no increase in ET 72 hours later. Out of ten patients, four patients received a single infusion, two patients received two infusions, and four patients received three infusions. The embryos were transferred when the ET reached ≥7 mm. ET was measured at the uterine longitudinal axis at the thickest point. To determine ET, three measurements were made, and the average of those measures was noted. The primary outcome measure was ET, determined by transvaginal sonography, and the secondary outcome measure was clinical pregnancy following embryo transfer.

Results:

The mean increase in ET was 1.8–2.25 mm. In 8 (80%) patients, there was an increase of 7–7.5 mm in ET. ET thickness did not improve in 2 patients (20%), and it was <6 mm after three infusions of PRP. Further, of the eight patients who had embryo transfer and became pregnant, six patients had a clinical pregnancy with visible cardiac activity at 6 weeks, while two patients had a missed abortion in the first trimester. Six patients had a successful delivery.

Conclusion:

This study revealed that PRP could support endometrial growth, improving pregnancy outcomes in patients who have thin endometrium. PRP is a novel treatment option for endometrial thinning and poor response to IVF. The findings of the current pilot study support the need for large-scale, randomized, controlled trials in this field.
RASCH MODEL ANALYSIS ON MATHEMATICS TEST INSTRUMENTS: BIBLIOSHINY (1983-2023)
Authors: Zafrullah  , Sa'adatul Ulwiyah  , Nofriyandi
Published: May 2024

The Rasch Model is a very useful tool in testing the quality of a measurement instrument, including mathematics tests. The Rasch model is part of item response theory which can classify item and person calculations in one distribution map. This research analyzes research trends regarding Rasch models in mathematics instruments, using bibliometric analysis to understand the current state of research in this field. From the analysis obtained, it can be said that publications regarding Rasch models in mathematical instruments have increased rapidly from 1983 to 2023, with a total of 173 articles. Universiti Kebangsaan Malaysia holds the highest affiliation with 13 articles. The Journal of Applied Measurement is the most prolific publication with 10 articles and 113 citations. Printy (2008) and Clements et al., (2008) are the sources with the most total citations, namely 139 citations. Azrilah Abdul Aziz, Clelia Cascella, Chiara GIBERTI, and Azami Zaharim are the authors with the largest number of articles discussing Rasch models in mathematical instruments with 4 articles. New themes that emerge in this analysis are mathematics education, engineering education, validity, reliability, gender, and differential item functioning so that future researchers can consider the keywords above
ВЫБОР И НАСТРОЙКА ПАРАМЕТРОВ РЕГУЛЯТОРА СИСТЕМЫ УПРАВЛЕНИЯ С ОБЪЕКТОМ УПРАВЛЕНИЯ ТРЕТЬЕГО ПОРЯДКА
Authors: Бабочкин М.А.
Published: May 2024

В статье представлена линейная, одноконтурная, замкнутая система управления. Разработана математическая модель замкнутой системы управления, состоящая из управляющего устройства и объекта управления и реализованная в среде динамического моделирования SimlnTech. Осуществлен выбор и настройка параметров для управляющего устройства.
The iron-catalysed Suzuki coupling of aryl chlorides
Authors: Rowsell Benjamin , O'Brien Harry , Athavan Gayathri , Daley-Dee Patrick , Krieger Johannes , Richards Emma , Heaton Karl , Fairlamb Ian , Bedford Robin
Published: May 2024

A simple iron-based catalyst with an N-heterocyclic carbene ligand can be used to excellent effect in the previously unknown Suzuki biaryl coupling of aryl chloride substrates with aryl boronic esters activated by an organolithium reagent. Mechanistic studies suggest the possible involvement of Fe(I) as the lowest oxidation state on the catalytic manifold and show that the challenging step is not activation of the aryl chloride substrate, but rather the transmetallation step. These findings are likely to pave the way for a renaissance of iron-catalysed carbon-carbon bond-forming transformations with ‘soft’ nucleophilic coupling partners.
IEV2Mol: Molecular Generative Model Considering Protein-Ligand Interaction Energy Vectors
Authors: Ozawa Mami , YASUO NOBUAKI , Sekijima Masakazu
Published: May 2024

Generating drug candidates with desired protein‒ligand interactions is a significant challenge in structure-based drug design. In this study, a new generative model, IEV2Mol, is proposed that incorporates interaction energy vectors (IEVs) between proteins and ligands obtained from docking simulations, which quantitatively capture the strength of each interaction type, such as hydrogen bonds, electrostatic interactions, and van der Waals forces. By integrating this IEV into an end-to-end variational autoencoder (VAE) framework that learns the chemical space from SMILES and minimizes the reconstruction error of the SMILES, the model can more accurately generate compounds with the desired interactions. To evaluate the effectiveness of IEV2Mol, we performed benchmark comparisons with randomly selected compounds, unconstrained VAE models (JT-VAE), and compounds generated by RNN models based on interaction fingerprints (IFP-RNN). The results show that the compounds generated by IEV2Mol retain a significantly greater percentage of the binding mode of the query structure than those of the other methods. Furthermore, IEV2Mol was able to generate compounds with interactions similar to those of the input compounds, regardless of structural similarity. The source code and trained models for IEV2Mol, JT-VAE, and IFP-RNN designed for generating compounds active against the DRD2 receptor, as well as the datasets (DM-QP-1M, DRD2 Active, and ChEMBL33) utilized in this study, are released under the MIT License and available at https://github.com/sekijima-lab/IEV2Mol.
Quantitative advantages of corrosion sensing using fluorescence, microscopy, and single-molecule detection
Authors: Siegel Mark , Liu Lianlian , Pfaffenberger Zechariah , Kisley Lydia
Published: May 2024

The corrosion of metals and alloys is a fundamental issue in modern society. Understanding the mechanisms that cause and prevent corrosion are integral to saving millions of dollars each year and to ensure the safe use of infrastructure subject to the hazardous degrading effects of corrosion. Despite this, corrosion detection techniques have lacked precise, quantitative information, with industries taking a top-down, macroscale approach of analyzing corrosion with tests that span months to years and yield qualitative information. Fluorescence, a well-established optical method, can fill the niche of early-stage, quantitative corrosion detection and can be employed for both bulk and localized testing over time. The latter, fluorescence microscopy, can be pushed to greater levels of detail with single-molecule microscopy, achieving nanometer spatial and sub-second temporal resolutions of corrosion that allow for the extraction of dynamic information and kinetics. This review will present how fluorescence microscopy can provide researchers a molecular view into the chemical mechanisms of corrosion at interfaces and allow for faster, quantitative studies of how to detect and prevent corrosion.
Stabilization of the elusive or non-existent “YbMnPt” phase by chemical heterogeneity: The pseudo-ternary phases Eu0.28Yb0.72MnPt and YbCd0.13Mn0.87Pt with TiNiSi type structure
Authors: Ponou Simeon , Mudring Anja-Verena , Friedrich Benedikt
Published: May 2024

The ternary RE-Mn-Pt systems (RE = rare-earth metal) have remained surprisingly vacant. Our attempts to stabilize hypo-thetical equiatomic “REMnPt” phases that are isovalent to RECdPt were found to be extremely challenging. However, us-ing metal fluxes synthesis approaches, two quasi-ternary phases Eu0.28Yb0.72MnPt and YbCd0.13Mn0.87Pt, with stoichi-ometries at the vicinity of the elusive “YbMnPt” phase, were obtained by reacting mixtures of the elements at high tem-perature with large excess of Eu and Cd, respectively. The two title compounds crystallize in the orthorhombic TiNiSi type structure (space group, Pnma), according to single crystal X-ray diffraction data, with Eu/Yb or Cd/Mn atomic mixing at the corresponding atomic sites. Noteworthy, the two phases feature Mn (3d5) linear zigzag chains with very similar Mn–Mn distances of 2.97 Å, longer than the sum of Mn covalent radii (2.74 Å), but non-negligeable. The Mn chains also interact strongly with the surrounding Pt atoms to form the polyanionic {MnPt} framework. The rare-earth metals Yb and Eu are arguably divalent and, we could surmise that the apparent non-existence of the pristine “YbMnPt” phase can be ascribed to geometric frustrations as it can be the result of packing mismatched between the cationic and anionic sublat-tices. Hence, partial isovalent substitutions at either Yb position by larger Eu atom or at Mn position by larger Cd atom may be necessarily to optimize the atomic packing. Our findings further demonstrate that chemical heterogeneity can be vital for the stability of certain classes of elusive materials in general.
Synthesis of 3-formyl-6-azaindoles via Vilsmeier-Haack formylation of 3-amino-4-methyl pyridines
Authors: Ivonin Sergey , Voloshchuk Volodymyr , Stepanova Diana , Ryabukhin Serhiy , Volochnyuk Dmytro
Published: May 2024

An efficient method for the preparation of 6-azaindoles bearing 3-formyl functionality from commercially available substrates with (ortho-methyl)aminopyridine moiety is described. This transformation features a distinct, though broad, substrate scope, and simple experimental procedure and can easily be scaled up to 40 g of the target formyl derivative. The structural characteristics of pyridine substrates that allow them to be successfully used in the reaction were investigated and discussed. Collected observations were mechanistically rationalized and the proposed mechanism was additionally confirmed by spectroscopic studies. Mechanistic studies clearly reveal the crucial role of the methyl group activation by in situ protonation of in-ring nitrogen atom. Functional group interconversions employing synthesized 3-formyl-6-azaindoles additionally prove this building block utility for MedChem investigations.
Benchmarking Quantum Mechanical Levels of Theory for Valence Parametrization in Force Fields
Authors: Behara Pavan Kumar , Jang Hyesu , Horton Joshua , Gokey Trevor , Dotson David , Boothroyd Simon , Bayly Christopher , Cole Daniel , Wang Lee-Ping , Mobley David
Published: May 2024

A wide range of density functional methods and basis sets are available to derive the electronic structure and properties of molecules. Quantum mechanical calculations are too computationally intensive for routine simulation of molecules in the condensed phase, prompting the development of computationally efficient force fields based on quantum mechanical data. Parametrizing general force fields, which cover a vast chemical space, necessitates generating sizable quantum mechanical datasets with optimized geometries and torsion scans. To achieve this efficiently, it is crucial to choose a quantum mechanical method that balances computational cost and accuracy. In this study we seek to assess the accuracy of quantum mechanical theory for specific properties such as conformer energies, and torsion energetics. To comprehensively evaluate various methods, we focus on a representative set of 59 diverse small molecules, comparing approximately 25 combinations of functional and basis sets against the reference level coupled cluster calculations at complete basis set limit.
Platinum-catalyzed Isomerization of Cyclopropenes to 1,3-Dienes
Authors: Smyrnov Vladyslav , Homassel Antonin , Choudhury Leander , Waser Jerome
Published: May 2024

Herein we report a platinum-catalyzed isomerization of cyclopropenes to 1,3-dienes. Diverse dienylated alcohols were ob-tained in 42-98% yield. The synthetic potential of the products was demonstrated by their use in Diels-Alder cycloadditions with various dienophiles. Isotope labelling studies provide strong support for a mechanism involving pericyclic [1,5]-σ-bond rearrangement of a vinyl platinum carbene intermediate.
Mechanism of Ni-NHC CO2 Reduction Catalysis Predominantly Affording Formate via Attack of Metal Hydride to CO2
Authors: Liao Chen , Yamauchi Kosei , Sakai Ken
Published: May 2024

The catalytic role of hydride intermediate in the CO2 reduction to formate (HCOO−) by NiII-NHC complexes is investigated in detail by density functional theory (DFT) calculations. It is found that a NiII-hydride is sufficiently hydridic to facilitate the efficient transfer of hydride to the carbon center of CO2, leading to the HCOO− production. Importantly, the direct hydride transfer path proposed here bypasses the conventional CO2 insertion into a metal-hydride bond. This mechanism is elucidated through a detailed analysis of the free energy changes of the reaction and the activation barriers, where key parameters such as reduction potentials, pKa values, and the thermodynamics of hydride transfer are thoroughly evaluated. The thermodynamic hydricity of the NiII-hydride, calculated to be ΔGH− = 19.2 kcal/mol, is in sharp contrast with the less effective NiIII-hydride with ΔGH− = 52.4 kcal/mol, highlighting the enhanced reactivity of NiII-hydride in HCOO− formation. Additionally, an examination of the competitive formation of CO and H2 reveals the preferential tendency of NiII-hydride to produce HCOO− over these byproducts. Insights into the influence of the pKa for the proton source on the feasibility of H2 production and HCOO− selectivity are also provided, suggesting a way to optimize reaction conditions for improved selectivity and efficiency. Our findings provide a comprehensive understanding of the CO2 reduction to HCOO− by NiII-NHC catalysts, emphasizing the direct hydride transfer mechanism rather than the classical CO2 insertion mechanism.
Fragment correlation mass spectrometry: determining the structures of biopolymers in a complex mixture without isolating individual components
Authors: Li Yangjie , Cavet Guy L , Zare Richard N , Driver Taran
Published: May 2024

Fragment correlation mass spectrometry correlates ion pairs generated from the same fragmentation pathway, achieved by covariance mapping of tandem mass spectra generated with an unmodified linear ion trap without pre-separation. We enable identification of different precursors at different charge states in a complex mixture from a large isolation window, empowering a new analytical approach for data-independent acquisition. The method resolves and matches isobaric fragments, internal ions, and disulfide bond fragments.
Temporal Analysis of Products (TAP) Reactor Study of the Dynamics of CO2 Interaction with a Ru/g-Al2O3 Supported Catalyst II: Interaction Strength, Formation of Intermediates and Oxygen Exchange
Authors: Fauth Corinna , Abdel-Mageed Ali M. , Behm R. Jürgen
Published: May 2024

Continuing a comprehensive study of the reduction of COx over supported Ru catalysts, we explored the interaction of CO2 with Ru/g-Al2O3 by TAP reactor measurements, focusing on dynamic aspects in adsorption/desorption, reaction and oxygen exchange processes. Pulse shape analysis in H2/CO2 multipulse sequences provides information on the interaction of reactant/product species with the catalyst. The measurements provide information on the dynamic build-up of reaction intermediates and more stable adspecies during pulsing, and its relation to CH4 formation. Facile oxygen exchange between CO2 and catalyst, followed by isotope labelling experiments, is quantitatively reconciled in a simple model, relating the ratio between different CO2 isotopologues to the 18O : 16O ratio in the total exchangeable oxygen on the surface and in the CO2 pulse. The results provide detailed insight into various aspects of the interaction between CO2 and Ru/Al2O3 catalysts important for a mechanistic understanding of various catalytic reactions involving CO2.
delta-Amination of Alkyl Alcohols via Energy Transfer Photocatalysis
Authors: Cristobal Christian , Alonso Ines , Cabrera-Afonso María J. , Adrio Javier , Ribagorda Maria
Published: May 2024

Amino alcohols play a crucial role in the realm of biologically active compounds due to their functional diversity. In this study, we introduce a metal-free energy transfer (EnT) photocatalytic method for the preparation of 1,4-aminoalcohols from readily available alcohols feedstocks. The key feature of this transformation is the simultaneous generation of an iminyl and oxygen-centered radicals via EnT. The process embraces a fragmentation/decarboxylation/1,5-HAT (hydrogen atom transfer) processes leading to the formation of a C(sp3)-hybridized radical, which undergo a selective radical-radical cross-coupling or a radical chain event to yield the desired products. In addition, the protocol was also found suitable for N-tosylamines giving rise to 1,4-diamines. Our approach combines experimental mechanistic investigations with detailed computational studies using density functional theory (DFT) that provide insights into the reaction mechanism. This innovative method offers a novel route for the preparation of δ-amino alkyl alcohols and amines.
DUAL SLIDING MODE CONTROLLER FOR HYBRID AC-DC MICROGRID SYSTEM
Authors: Chaturvedi Stuti , Bhattacharya Ananyo
Published: May 2024

As human beings are advancing in technology the demand for power is drastically increasing. To cope up with these increasing energy demands renewable energy was included in the power system in the early 20th century. A rise in the usage of renewable energy sources for power production has been motivated by concerns about global climate change and air pollution. These new sources of renewable energy are in high demand for creating microgrids that give energy independence to remote populations. If these microgrids are to be successful, they must be able to function in either an isolated or a linked state. These standards are very difficult to meet. Small and medium power networks in isolated mode are, in fact, very susceptible to variations in consumer power demand and changes in the power generated by generators. Two independently regulated solar power sources, power storage, as well as a resistive load are all included in this study’s distributed photovoltaic (DP) system design. Sliding mode controllers are used to regulate the cascaded DC-DC boost converters on each PV panel. A DSM-PI controller and a PI-sliding mode controller will be used to regulate power converters that connect the source and the common DC bus. Using numerical simulations, this research compares the MPPT algorithm’s performance in each operating state to the accuracy of the supervisory controller. The DSM-PI controller is more efficient as compared to conventional sliding mode controller. All the results are generated using MATLAB Simulink software.