bluuebunny/crossref_metadata_2025 huggingface dataset:
Closing the Gender Gap in Fragile X Syndrome: Review of Females with Fragile X Syndrome and Preliminary Research Findings
Authors: Bartholomay Kristi , Lee Cindy , Bruno Jennifer , Lightbody Amy , Reiss Allan
Published: January 2019

Fragile X syndrome (FXS) is a genetic condition known to increase the risk of cognitive impairment and socio-emotional challenges in affected males and females. To date, the vast majority of research on FXS has predominantly targeted males, who usually exhibit greater cognitive impairment compared to females. Due to their typically milder phenotype, females may have more potential to attain a higher level of independence and quality of life than their male counterparts. However, the constellation of cognitive, behavioral, and, particularly, socio-emotional challenges present in many females with FXS often preclude them from achieving their full potential. It is, therefore, critical that more research specifically focuses on females with FXS to elucidate the role of genetic, environmental, and socio-emotional factors on outcome in this often-overlooked population.
Self-Esteem Group: Useful Intervention for Inpatients with Anorexia Nervosa?
Authors: Adamson James , Ozenc Cansu , Baillie Claire , Tchanturia Kate
Published: January 2019

Low self-esteem is a common feature in Anorexia Nervosa (AN) and has been hypothesised to act as a predisposing, precipitating, and perpetuating factor. The aim of this study was to assess the effectiveness of a Cognitive Behavioural Therapy (CBT)-based self-esteem group in a naturalistic setting of patients with AN in an inpatient treatment programme. Included in this study were 119 female patients diagnosed with AN, with all participants completing self-report questionnaires before and after the intervention. The group consisted of five to six weekly sessions. The self-esteem group led to a statistically significant improvement in self-esteem, which could not be explained by an increase in BMI alone, suggesting that the group is facilitating positive changes within an AN group. The group also had a small effect on improving patients self-perceived ability to change. These findings suggest that the brief self-esteem group has some benefits in improving patients’ self-esteem/self-efficacy and should be replicated in the future with a control condition to confirm findings.
Active BIM Approach to Optimize Work Facilities and Tower Crane Locations on Construction Sites with Repetitive Operations
Authors: Dasović Borna , Galić Mario , Klanšek Uroš
Published: January 2019

This paper presents an active building information modeling (BIM) approach for work facilities and the optimal positioning of tower cranes on construction sites with repetitive operations. In this context, the metamorphosis of a passive BIM approach into an active approach is described. Here, the enhancement of the construction-ready BIM model starts with the export of the optimization input parameters, such as the 3D coordinates of the building, perimeter of the construction site, space for feasible solutions, relevant segment of the building with repetitive works, etc. Depending on the complexity of the problem, the user selects a suitable optimization approach and formulates the tower crane positioning optimization problem with the objective of minimizing the total duration of the operation’s cycle. Similarly, according to the model formulation, the user also chooses the optimization tool, including the search algorithm. The final step involves the post-optimal analysis and importing of the optimal solution into the BIM. An application example is demonstrated at the end of the paper to show the advantages of the proposed approach in which the optimization model has significantly improved the initial solution of the crane and depot positions.
Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells
Authors: Luna Jesus I. , Grossenbacher Steven K. , Sturgill Ian R. , Ames Erik , Judge Sean J. , Bouzid Lyes A. , Darrow Morgan A. , Murphy William J. , Canter Robert J.
Published: January 2019

Tumor cells harboring stem-like/cancer stem cell (CSC) properties have been identified and isolated from numerous hematological and solid malignancies. These stem-like tumor cells can persist following conventional cytoreductive therapies, such as chemotherapy and radiotherapy, thereby repopulating the tumor and seeding relapse and/or metastasis. We have previously shown that natural killer (NK) cells preferentially target stem-like tumor cells via non- major histocompatibility complex (MHC) restricted mechanisms. Here, we demonstrated that the proteasome inhibitor, bortezomib, augments NK cell targeting of stem cell-like tumor cells against multiple solid human tumor-derived cancer lines and primary tissue samples. Mechanistically, this was mediated by the upregulation of cell surface NK ligands MHC class I chain-related protein A and B (MICA and MICB) on aldehyde dehydrogenases (ALDH)-positive CSCs. The increased expression of MICA and MICB on CSC targets thereby enhanced NK cell mediated killing in vitro and ex vivo from both human primary tumor and patient-derived xenograft samples. In vivo, the combination of bortezomib and allogeneic NK cell adoptive transfer in immunodeficient mice led to increased elimination of CSCs as well as tumor growth delay of orthotopic glioblastoma tumors. Taken together, our data support the combination bortezomib and NK transfer as a strategy for both CSC targeting and potentially improved outcomes in clinical cancer patients.
The Opposing Contribution of SMS1 and SMS2 to Glioma Progression and Their Value in the Therapeutic Response to 2OHOA
Authors: Fernández-García Paula , Rosselló Catalina A. , Rodríguez-Lorca Raquel , Beteta-Göbel Roberto , Fernández-Díaz Javier , Lladó Victoria , Busquets Xavier , Escribá Pablo V.
Published: January 2019

Background: 2-Hydroxyoleic acid (2OHOA) is particularly active against glioblastoma multiforme (GBM) and successfully finished a phase I/IIA trial in patients with glioma and other advanced solid tumors. However, its mechanism of action is not fully known. Methods: The relationship between SMS1 and SMS2 expressions (mRNA) and overall survival in 329 glioma patients was investigated, and so was the correlation between SMS expression and 2OHOA’s efficacy. The opposing role of SMS isoforms in 2OHOA’s mechanism of action and in GBM cell growth, differentiation and death, was studied overexpressing or silencing them in human GBM cells. Results: Patients with high-SMS1 plus low-SMS2 expression had a 5-year survival ~10-fold higher than patients with low-SMS1 plus high-SMS2 expression. SMS1 and SMS2 also had opposing effect on GBM cell survival and 2OHOA’s IC50 correlated with basal SMS1 levels and treatment induced changes in SMS1/SMS2 ratio. SMSs expression disparately affected 2OHOA’s cancer cell proliferation, differentiation, ER-stress and autophagy. Conclusions: SMS1 and SMS2 showed opposite associations with glioma patient survival, glioma cell growth and response to 2OHOA treatment. SMSs signature could constitute a valuable prognostic biomarker, with high SMS1 and low SMS2 being a better disease prognosis. Additionally, low basal SMS1 mRNA levels predict positive response to 2OHOA.
Capture of Circulating Tumour Cell Clusters Using Straight Microfluidic Chips
Authors: Kulasinghe Arutha , Zhou Jian , Kenny Liz , Papautsky Ian , Punyadeera Chamindie
Published: January 2019

Circulating tumour cells (CTCs) are the metastatic precursors to distant disease in head and neck cancers (HNCs). Whilst the prognostic and predictive value of single CTCs have been well documented, the role of CTC clusters, which potentially have a higher metastatic capacity are limited. In this study, the authors used a novel straight microfluidic chip to focus and capture CTCs. The chip offers high cell recoveries with clinically relevant numbers (10–500 cells/mL) without the need for further purification. Single CTCs were identified in 10/21 patient samples (range 2–24 CTCs/mL), CTC clusters in 9/21 patient samples (range 1–6 CTC clusters/mL) and circulating tumour microemboli (CTM) in 2/21 samples. This study demonstrated that CTC clusters contain EGFR amplified single CTCs within the cluster volume. This novel microfluidic chip demonstrates the efficient sorting and preservation of single CTCs, CTC clusters and CTMs. The authors intend to expand this study to a larger cohort to determine the clinical implication of the CTC subsets in HNC.
Catalytic Hydrodechlorination of Chlorophenols in a Continuous Flow Pd/CNT-Ni Foam Micro Reactor Using Formic Acid as a Hydrogen Source
Authors: Xiong Jun , Ma Ying
Published: January 2019

Catalytic hydrodechlorination (HDC) has been considered as a promising method for the treatment of wastewater containing chlorinated organic pollutants. A continuous flow Pd/carbon nanotube (CNT)-Ni foam micro reactor system was first developed for the rapid and highly efficient HDC with formic acid (FA) as a hydrogen source. This micro reactor system, exhibiting a higher catalytic activity of HDC than the conventional packed bed reactor, reduced the residence time and formic acid consumption significantly. The desired outcomes (dichlorination >99.9%, 4-chlorophenol outlet concentration <0.1 mg/L) can be obtained under a very low FA/substrate molar ratio (5:1) and short reaction cycle (3 min). Field emission scanning electron microcopy (FESEM) and deactivation experiment results indicated that the accumulation of phenol (the main product during the HDC of chlorophenols) on the Pd catalyst surface can be the main factor for the long-term deactivation of the Pd/CNT-Ni foam micro reactor. The catalytic activity deactivation of the micro reactor could be almost completely regenerated by the efficient removal of the absorbed phenol from the Pd catalyst surface.
Catalytic Decomposition of an Energetic Ionic Liquid Solution over Hexaaluminate Catalysts
Authors: Hong Sunghoon , Heo Sujeong , Kim Wooram , Jo Young Min , Park Young-Kwon , Jeon Jong-Ki
Published: January 2019

The objective of this study was to determine the effect of a synthesis procedure of Sr hexaaluminate on catalytic performance during the decomposition of ionic liquid monopropellants based on ammonium dinitramide (ADN) and hydroxyl ammonium nitrate (HAN). Sr hexaaluminates were prepared via both coprecipitation and a sol–gel process. The surface area of hexaaluminate synthesized via the coprecipitation method was higher than that of hexaaluminate synthesized by the sol–gel process, and calcined at the same temperature of 1200 °C or more. This is because of the sintering of α-Al2O3 on the hexaaluminate synthesized via the sol–gel process, which could not be observed on the catalysts synthesized via the coprecipitation method. The hexaaluminate synthesized via coprecipitation showed a lower decomposition onset temperature during the decomposition of ADN- and HAN-based liquid monopropellants in comparison with the catalysts synthesized via the sol–gel process, and calcined at the same temperature of 1200 °C or more. This is attributed to the differences in the Mn3+ concentration and the surface area between the two hexaaluminates. Consequently, the hexaaluminate synthesized via coprecipitation which calcined above 1200 °C showed high activity during the decomposition of energetic ionic liquid monopropellants compared with the hexaaluminate synthesized via the sol–gel process.
The Catalytic Mechanism of Steroidogenic Cytochromes P450 from All-Atom Simulations: Entwinement with Membrane Environment, Redox Partners, and Post-Transcriptional Regulation
Authors: Spinello Angelo , Ritacco Ida , Magistrato Alessandra
Published: January 2019

Cytochromes P450 (CYP450s) promote the biosynthesis of steroid hormones with major impact on the onset of diseases such as breast and prostate cancers. By merging distinct functions into the same catalytic scaffold, steroidogenic CYP450s enhance complex chemical transformations with extreme efficiency and selectivity. Mammalian CYP450s and their redox partners are membrane-anchored proteins, dynamically associating to form functional machineries. Mounting evidence signifies that environmental factors are strictly intertwined with CYP450s catalysis. Atomic-level simulations have the potential to provide insights into the catalytic mechanism of steroidogenic CYP450s and on its regulation by environmental factors, furnishing information often inaccessible to experimental means. In this review, after an introduction of computational methods commonly employed to tackle these systems, we report the current knowledge on three steroidogenic CYP450s—CYP11A1, CYP17A1, and CYP19A1—endowed with multiple catalytic functions and critically involved in cancer onset. In particular, besides discussing their catalytic mechanisms, we highlight how the membrane environment contributes to (i) regulate ligand channeling through these enzymes, (ii) modulate their interactions with specific protein partners, (iii) mediate post-transcriptional regulation induced by phosphorylation. The results presented set the basis for developing novel therapeutic strategies aimed at fighting diseases originating from steroid metabolism dysfunction.
Effect of Fe2O3–ZrO2 Catalyst Morphology on Sulfamethazine Degradation in the Fenton-Like Reaction
Authors: Gao Pan , Hao Mengjie , He Yue , Song Yuan , Yang Shaoxia
Published: January 2019

Fe2O3–ZrO2 catalysts with different morphologies (nanoplates (HZNPs), nanorods (HZNRs), nanocubes (HZNCs), and nanotubes (HZNTs)) were prepared by a hydrothermal method to investigate the effect of the morphology on the catalytic performance in the Fenton-like reaction for sulfamethazine (SMT) degradation. The Fe2O3–ZrO2 catalysts were characterized by scanning electron microscope (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Brunauer–Emmett–Teller (BET) analysis. The H2O2 adsorption and the Fe2+ density sites on the Fe2O3–ZrO2 catalysts had a close relationship with the morphologies and exhibited an important effect on the ·OH formation in the Fenton-like reaction. Free ·OH radicals were the main oxidative species in the reaction, and the normalized ·OH concentration per surface area of the catalysts was 4.52, 2.24, 2.20, and 0.37 μmol/m2 for HZNPs, HZNRs, HZNCs, and HZNTs, respectively. The Fe2O3–ZrO2 catalysts with different morphologies showed good catalytic performance, and the order of SMT degradation was HZNPs > HZNRs > HZNCs > HZNTs. Total SMT removal was achieved in the Fenton-like reaction over HZNPs at pH 3.0 and 45 °C after 240 min.
Is Autophagy Involved in the Diverse Effects of Antidepressants?
Authors: Rein Theo
Published: January 2019

Autophagy has received increased attention as a conserved process governing cellular energy and protein homeostasis that is thus relevant in a range of physiological and pathophysiological conditions. Recently, autophagy has also been linked to depression, mainly through its involvement in the action of antidepressants. Some antidepressant drugs and psychotropic medication have been reported to exert beneficial effects in other diseases, for example, in cancer and neurodegenerative diseases. This review collates the evidence for the hypothesis that autophagy contributes to the effects of antidepressants beyond depression treatment.
Recent Advances in CRISPR/Cas9-Mediated Genome Editing in Dictyostelium
Authors: Muramoto Tetsuya , Iriki Hoshie , Watanabe Jun , Kawata Takefumi
Published: January 2019

In the last 30 years, knockout of target genes via homologous recombination has been widely performed to clarify the physiological functions of proteins in Dictyostelium. As of late, CRISPR/Cas9-mediated genome editing has become a versatile tool in various organisms, including Dictyostelium, enabling rapid high-fidelity modification of endogenous genes. Here we reviewed recent progress in genome editing in Dictyostelium and summarised useful CRISPR vectors that express sgRNA and Cas9, including several microorganisms. Using these vectors, precise genome modifications can be achieved within 2–3 weeks, beginning with the design of the target sequence. Finally, we discussed future perspectives on the use of CRISPR/Cas9-mediated genome editing in Dictyostelium.
Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells
Authors: Saladini Serena , Aventaggiato Michele , Barreca Federica , Morgante Emanuela , Sansone Luigi , Russo Matteo A. , Tafani Marco
Published: January 2019

Metformin has been shown to inhibit glutaminase (GLS) activity and ammonia accumulation thereby reducing the risk of hepatic encephalopathy in type 2 diabetic patients. Since tumour cells are addicted to glutamine and often show an overexpression of glutaminase, we hypothesize that the antitumoral mechanism of metformin could be ascribed to inhibition of GLS and reduction of ammonia and ammonia-induced autophagy. Our results show that, in different tumour cell lines, micromolar doses of metformin prevent cell growth by reducing glutamate, ammonia accumulation, autophagy markers such as MAP1LC3B-II and GABARAP as well as degradation of long-lived proteins. Reduced autophagy is then accompanied by increased BECN1/BCL2 binding and apoptotic cell death. Interestingly, GLS-silenced cells reproduce the effect of metformin treatment showing reduced MAP1LC3B-II and GABARAP as well as ammonia accumulation. Since metformin is used as adjuvant drug to increase the efficacy of cisplatin-based neoadjuvant chemotherapy, we co-treated tumour cells with micromolar doses of metformin in the presence of cisplatin observing a marked reduction of MAP1LC3B-II and an increase of caspase 3 cleavage. In conclusion, our work demonstrates that the anti-tumoral action of metformin is due to the inhibition of glutaminase and autophagy and could be used to improve the efficacy of chemotherapy.
Family Income at Birth and Risk of Attention Deficit Hyperactivity Disorder at Age 15: Racial Differences
Authors: Assari Shervin , Caldwell Cleopatra
Published: January 2019

Background: Socioeconomic status (SES) resources protect children and adults against the risk of medical and psychiatric conditions. According to the Minorities’ Diminished Returns theory, however, such protective effects are systemically weaker for the members of racial and ethnic minority groups compared to Whites. Aims: Using a national data set with 15 years of follow up, we compared Black and White youth for the effects of family SES at birth on the risk of Attention Deficit Hyperactivity Disorder (ADHD) at age 15. Methods: The Fragile Families and Child Wellbeing Study (FFCWS, 1998–2016) is a longitudinal prospective study of urban youth from birth to age 15. This analysis included 2006 youth who were either White (n = 360) or Black (n = 1646). The independent variable was family income, the dependent variable was ADHD at age 15. Child gender, maternal age, and family type at birth were covariates, and race was the focal moderator. We ran logistic regressions in the overall sample and specific to race. Results: In the overall sample, high family income at birth was not associated with the risk of ADHD at age 15, independent of all covariates. Despite this relationship, we found a significant interaction between race and family income at birth on subsequent risk of ADHD, indicating a stronger effect for Whites compared to Blacks. In stratified models, we found a marginally significant protective effect of family SES against the risk of ADHD for White youths. For African American youth, on the other hand, family SES was shown to have a marginally significant risk for ADHD. Conclusions: The health gain that follows family income is smaller for Black than White families, which is in line with the Minorities’ Diminished Returns. The solution to health disparities is not simply policies that aim to reduce the racial gap in SES, because various racial health disparities in the United States are not due to differential access to resources but rather the impact of these resources on health outcomes. Public policies, therefore, should go beyond equalizing access to resources and also address the structural racism and discrimination that impact Blacks’ lives. Policies should fight racism and should help Black families to overcome barriers in their lives so they can gain health from their SES and social mobility. As racism is multi-level, multi-level interventions are needed to tackle diminished returns of SES.
Can Protection Motivation Theory Explain Farmers’ Adaptation to Climate Change Decision Making in The Gambia?
Authors: Bagagnan Abdoul Rasmane , Ouedraogo Issa , M. Fonta William , Sowe Musa , Wallis Anne
Published: January 2019

In The Gambia, climate change has affected, and continues to affect, the agriculture sector. Thus, there is a need to develop and understand effective agricultural adaptation policies. The present study used protection motivation theory to describe farmers’ adoption of climate change adaptation measures in the Central River Region of The Gambia. Primary data were collected in eight communities of the region. A transect walk was conducted, followed by a survey of farmers (n = 283). Perception data collected referred back to the past 20 years, with stated implementation addressing current adaptation practices. Results showed that the perception variables, namely, severity, ability to withstand, and internal barriers, were significantly correlated with protection motivation, while protection motivation and stated implementation for water conservation technique were strongly correlated. Structural equation modeling confirmed the mediation role of protection motivation between farmers’ “stated implementation” of adaptation measures and their perception of climate variability. A decrease in soil water storage capacity, degradation of the quality of soil surface structure, and a decrease of the length of the growing season are all factors that motivate farmers to implement an adaptation measure. The cost of the implementation and farmers’ vulnerability are factors that prevent implantation of adaptation measures. This study suggested that farmers’ resilience should be improved and adaptation measures should be subsidized in order to make them more accessible to farmers.
An Ambient Curable Coating Material Based on the Michael Addition Reaction of Acetoacetylated Castor Oil and Multifunctional Acrylate
Authors: Wang Tong , Wang Jianli , He Xianfeng , Cao Zhiyuan , Xu Dongdong , Gao Fei , Zhong Jiang , Shen Liang
Published: January 2019

In this work a novel ambient curable coating was synthesized based on the Michael addition reaction of acetoacetylated castor oil and a multifunctional acrylate. In the research, we used hexamethylene diacrylate as crosslinker to optimize the reaction conditions and found that a ratio of acetoacetylated castor oil to acrylate groups of 1:1.5 and a catalyst (DBU) loading of 2 wt % provided an appropriate curing time. The acetoacetylated castor oil was characterized by 1H NMR and 13C NMR spectroscopy and the obtained coating characterized by FTIR to confirm the functionalization reaction. The tensile strength, cross linking density, and thermal properties of the resulting thermosets were investigated by dynamic mechanical analysis (DMA), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA). Results demonstrated that the glass transition temperatures, tensile strength, and thermal degradation were significantly improved with higher cross-linking density. Moreover, we prepared films with different multifunctional acrylate cross-linkers and found that with the increase of cross-linking density, the swelling of the film rate decreased. Overall, thermosets made from Michael crosslinking technology provided a highly bio-based coating system.
A Review on Micropitting Studies of Steel Gears
Authors: Liu Huaiju , Liu Heli , Zhu Caichao , Zhou Ye
Published: January 2019

With the mounting application of carburized or case-hardening gears and higher requirements of heavy-load, high-speed in mechanical systems such as wind turbines, helicopters, ships, etc., contact fatigue issues of gears are becoming more preponderant. Recently, significant improvements have been made on the gear manufacturing process to control subsurface-initiated failures, hence, gear surface-initiated damages, such as micropitting, should be given more attention. The diversity of the influence factors, including gear materials, surface topographies, lubrication properties, working conditions, etc., are necessary to be taken into account when analyzing gear micropitting behaviors. Although remarkable developments in micropitting studies have been achieved recently by many researchers and engineers on both theoretical and experimental fields, large amounts of investigations are yet to be further launched to thoroughly understand the micropitting mechanism. This work reviews recent relevant studies on the micropitting of steel gears, especially the competitive phenomenon that occurs among several contact fatigue failure modes when considering gear tooth surface wear evolution. Meanwhile, the corresponding recent research results about gear micropitting issues obtained by the authors are also displayed for more detailed explanations.
On the Nature of Luminescence Thermochromism of Multinuclear Copper(I) Benzoate Complexes in the Crystalline State
Authors: Jarzembska Katarzyna N. , Hapka Michał , Kamiński Radosław , Bury Wojciech , Kutniewska Sylwia E. , Szarejko Dariusz , Szczęśniak Małgorzata M.
Published: January 2019

A model luminescent [(PhCO2)4Cu4] (Cu4) complex in the crystalline state was investigated via combined crystallographic and spectroscopic techniques contributed substantially by theoretical modelling. The complex appeared to exhibit luminescence thermochromism, i.e., red phosphorescence at room temperature which changes to green when lowering the temperature to 90 K. The low-energy emissive state was assigned as a cluster-centred triplet, 3CC. The emission from this state predicted in TDDFT (~635 nm) matches the experimental red band observed at 660–715 nm. In contrast, the nature of the high-energy “green” band was less straightforward. The next reached cluster-centred triplet excited state occurred to be energetically close to the experimental value of ~545 nm. The two excited states also exhibit significant metal-to-ligand and ligand-to-metal charge transfer characteristics, especially for solid-state distorted geometries. In both cases the cluster core was expected to become notably contracted when compared to the ground state. Time-resolved photocrystallographic results supported the computationally predicted core contraction upon excitation. Additionally, the differences between the spectroscopic behaviour of the related tetra- and hexanuclear copper(I) complexes, Cu4 and Cu6 (i.e., [(PhCO2)6Cu6]) in the crystalline state were discussed and examined. It appeared that crystal packing may constitute an important factor as far as the lack of luminescence thermochromism in the latter case is concerned. Synopsis: Structure–property relationships characterising a model luminescent [(PhCO2)4Cu4] (Cu4) complex in the crystalline state were investigated via combined crystallographic and spectroscopic techniques contributed by theoretical modelling, and compared with the properties of the related [(PhCO2)6Cu6] (Cu6) complex.
Steric Effects of Alkyl Substituents at N-Donor Bidentate Amines Direct the Nuclearity, Bonding and Bridging Modes in Isothiocyanato-Copper(II) Coordination Compounds
Authors: Mautner Franz A. , Fischer Roland C. , Torvisco Ana , Henary Maher M. , Milner Andrew , DeVillier Hunter , Karsili Tolga N. V. , Louka Febee R. , Massoud Salah S.
Published: January 2019

A series of Cu(II)-isothiocyanato coordination compounds derived from sterically hindered N-donor diamines were synthesized and characterized: catena-[Cu(Me3en)(μ-NCS)(NCS)] (1), catena-[Cu(NEt2Meen)(μ-NCS)(NCS)] (2), catena-[Cu(N,N,2,2-Me4pn)(μ-NCS)(NCS)] (3), the dimeric: [Cu2(N,N′-isp2en)2(µ-NCS)2(NCS)2] (4) and the monomeric compound [Cu(N,N′-t-Bu2en)(NCS)2] (5), where Me3en = N,N,N′-trimethylethylenediamine, NEt2Meen = N,N-diethyl-N′-methylethylenediamine, N,N,2,2-Me4pn = N,N,2,2-tetramethylpropylenediamine, N,N′-isp2en = N,N′-diisopropylethylenediamine and N,N′-t-Bu2en = N,N′-di(tert-butyl)ethylenediamine. The coordination compounds were characterized by elemental microanalyses, IR, and UV–Vis spectroscopy as well as single crystal X-ray crystallography. Density Functional Theory (DFT) was used to evaluate the role of steric effects in compounds 4 and 5 and how this may affect the adaption of a specific geometry, NCS-bonding mode, and the dimensionality of the resulting coordination compound.
Tripling the Optical Efficiency of Color-Converted Micro-LED Displays with Funnel-Tube Array
Authors: Gou Fangwang , Hsiang En-Lin , Tan Guanjun , Lan Yi-Fen , Tsai Cheng-Yeh , Wu Shin-Tson
Published: January 2019

Color-converted micro-LED displays consist of a mono-color micro-LED array and color conversion materials to achieve full color, while relieving the burden of epitaxial growth of three-color micro-LEDs. However, it usually suffers from low efficiency and color crosstalk due to the limited optical density of color conversion materials. With funnel-tube array, the optical efficiency of the color-converted micro-LED display can be improved by ~3X, while the crosstalk is eliminated. After optimization of the tapper angle, the ambient contrast ratio is also improved due to higher light intensity.
BLE RSS Measurements Dataset for Research on Accurate Indoor Positioning
Authors: Mendoza-Silva Germán Martín , Matey-Sanz Miguel , Torres-Sospedra Joaquín , Huerta Joaquín
Published: January 2019

RSS-based indoor positioning is a consolidated research field for which several techniques have been proposed. Among them, Bluetooth Low Energy (BLE) beacons are a popular option for practical applications. This paper presents a new BLE RSS database that was created to aid in the development of new BLE RSS-based positioning methods and to encourage their reproducibility and comparability. The measurements were collected in two university zones: an area among bookshelves in a library and an area of an office space. Each zone had its own batch of deployed iBKS 105 beacons, configured to broadcast advertisements every 200 ms. The collection in the library zone was performed using three Android smartphones of different brands and models, with beacons broadcasting at −12 dBm transmission power, while in the other zone the collection was performed using of one those smartphones with beacons configured to advertise at the −4 dBm, −12 dBm and −20 dBm transmission powers. Supporting materials and scripts are provided along with the database, which annotate the BLE readings, provide details on the collection, the environment, and the BLE beacon deployments, ease the database usage, and introduce the reader to BLE RSS-based positioning and its challenges. The BLE RSS database and its supporting materials are available at the Zenodo repository under the open-source MIT license.
Immunological Features in the Process of Blood Platelet-Induced Alloimmunisation, with a Focus on Platelet Component Transfusion
Authors: Garraud Olivier , Cognasse Fabrice , Moncharmont Pierre
Published: January 2019

Alloimmunisation to platelet antigens is not uncommon; a large number of females, having had pregnancies, developed antibodies to Human Leukocyte Antigen (HLA) moieties harboured on their foetuses’ cells (inherited from the father(s)) that may conflict with further pregnancies and transfused Platelet Components occasionally. This is possible since platelets constitutionally express HLA class I molecules (though in copy numbers that consistently differ among individuals). Platelets also express HPA moieties that are variants of naturally expressed adhesion and aggregation molecules; HPA differences between mothers and foetuses and between donors and recipients explain alloimmune conflicts and consequences. Lastly, platelets express ABO blood group antigens, which are rarely immunising, however transfusion mismatches in ABO groups seem to be related to immunisation in other blood and tissue groups. Transfusion also brings residual leukocytes that may also immunise through their copious copy numbers of HLA class I (rarely class II on activated T lymphocytes, B cells, and dendritic cells). In addition, residual red blood cells in platelet concentrates may induce anti-red blood cell allo-antibodies. This short review aims to present the main mechanisms that are commonly reported in alloimmunisation. It also critically endeavours to examine paths to either dampen alloimmunisation occurrences or to prevent them.
Information Theory in Neuroscience
Authors: Piasini Eugenio , Panzeri Stefano
Published: January 2019

This is the Editorial article summarizing the scope and contents of the Special Issue, Information Theory in Neuroscience.
Double Entropy Joint Distribution Function and Its Application in Calculation of Design Wave Height
Authors: Liu Guilin , Chen Baiyu , Jiang Song , Fu Hanliang , Wang Liping , Jiang Wei
Published: January 2019

Wave height and wave period are important oceanic environmental factors that are used to describe the randomness of a wave. Within the field of ocean engineering, the calculation of design wave height is of great significance. In this paper, a periodic maximum entropy distribution function with four undetermined parameters is derived by means of coordinate transformation and solving conditional variational problems. A double entropy joint distribution function of wave height and wave period is also derived. The function is derived from the maximum entropy wave height function and the maximum entropy periodic function, with the help of structures of the Copula function. The double entropy joint distribution function of wave height and wave period is not limited by weak nonlinearity, nor by normal stochastic process and narrow spectrum. Besides, it can fit the observed data more carefully and be more widely applicable to nonlinear waves in various cases, owing to the many undetermined parameters it contains. The engineering cases show that the recurrence level derived from the double entropy joint distribution function is higher than that from the extreme value distribution using the single variables of wave height or wave period. It is also higher than that from the traditional joint distribution function of wave height and wave period.
Gini Regressions and Heteroskedasticity
Authors: Charpentier Arthur , Ka Ndéné , Mussard Stéphane , Ndiaye Oumar Hamady
Published: January 2019

We propose an Aitken estimator for Gini regression. The suggested A-Gini estimator is proven to be a U-statistics. Monte Carlo simulations are provided to deal with heteroskedasticity and to make some comparisons between the generalized least squares and the Gini regression. A Gini-White test is proposed and shows that a better power is obtained compared with the usual White test when outlying observations contaminate the data.
Hyperspectral Image Denoising Based on Spectral Dictionary Learning and Sparse Coding
Authors: Song Xiaorui , Wu Lingda , Hao Hongxing , Xu Wanpeng
Published: January 2019

Processing and applications of hyperspectral images (HSI) are limited by the noise component. This paper establishes an HSI denoising algorithm by applying dictionary learning and sparse coding theory, which is extended into the spectral domain. First, the HSI noise model under additive noise assumption was studied. Considering the spectral information of HSI data, a novel dictionary learning method based on an online method is proposed to train the spectral dictionary for denoising. With the spatial–contextual information in the noisy HSI exploited as a priori knowledge, the total variation regularizer is introduced to perform the sparse coding. Finally, sparse reconstruction is implemented to produce the denoised HSI. The performance of the proposed approach is better than the existing algorithms. The experiments illustrate that the denoising result obtained by the proposed algorithm is at least 1 dB better than that of the comparison algorithms. The intrinsic details of both spatial and spectral structures can be preserved after significant denoising.
Step-Down Partial Power DC-DC Converters for Two-Stage Photovoltaic String Inverters
Authors: Zapata Jaime Wladimir , Kouro Samir , Carrasco Gonzalo , Meynard Thierry A.
Published: January 2019

Photovoltaic (PV) systems composed by two energy conversion stages are attractive from an operation point of view. This is because the maximum power point tracking (MPPT) range is extended, due to the voltage decoupling between the PV system and the dc-link. Nevertheless, the additional dc-dc conversion stage increases the volume, cost and power converter losses. Therefore, central inverters based on a single-stage converter, have been a mainstream solution to interface large-scale PV arrays composed of several strings connected in parallel made by the series connections of PV modules. The concept of partial power converters (PPC), previously reported as a voltage step-up stage, has not addressed in depth for all types of PV applications. In this work, a PPC performing voltage step-down operation is proposed and analyzed. This concept is interesting from the industry point of view, since with the new isolation standards of PV modules are reaching 1500 V, increasing both the size of the string and dc-link voltage for single-stage inverters. Since grid connection remains typically at 690 V, larger strings impose more demanding operation for single-stage central inverters (required to operate at lower modulation indexes and demand higher blocking voltage devices), making the proposed step-down PPC an attractive solution. Theoretical analysis and an experimental test-bench was built in order to validate the PPC concept, the control performance and the improvement of the conversion efficiency. The experimental results corroborate the benefits of using a PPC, in terms of increasing the system efficiency by reducing the processed power of the converter, while not affecting the system performance.
Medical Video Coding Based on 2nd-Generation Wavelets: Performance Evaluation
Authors: Ferroukhi Merzak , Ouahabi Abdeldjalil , Attari Mokhtar , Habchi Yassine , Taleb-Ahmed Abdelmalik
Published: January 2019

The operations of digitization, transmission and storage of medical data, particularly images, require increasingly effective encoding methods not only in terms of compression ratio and flow of information but also in terms of visual quality. At first, there was DCT (discrete cosine transform) then DWT (discrete wavelet transform) and their associated standards in terms of coding and image compression. The 2nd-generation wavelets seeks to be positioned and confronted by the image and video coding methods currently used. It is in this context that we suggest a method combining bandelets and the SPIHT (set partitioning in hierarchical trees) algorithm. There are two main reasons for our approach: the first lies in the nature of the bandelet transform to take advantage of capturing the geometrical complexity of the image structure. The second reason is the suitability of encoding the bandelet coefficients by the SPIHT encoder. Quality measurements indicate that in some cases (for low bit rates) the performance of the proposed coding competes with the well-established ones (H.264 or MPEG4 AVC and H.265 or MPEG4 HEVC) and opens up new application prospects in the field of medical imaging.
Optimization of Biodiesel Production Using Nanomagnetic CaO-Based Catalysts with Subcritical Methanol Transesterification of Rubber Seed Oil
Authors: Winoto Veronica , Yoswathana Nuttawan
Published: January 2019

The molar ratio of methanol to rubber seed oil (RSO), catalyst loading, and the reaction time of RSO biodiesel production were optimized in this work. The response surface methodology, using the Box–Behnken design, was analyzed to determine the optimum fatty acid methyl ester (FAME) yield. The performance of various nanomagnetic CaO-based catalysts—KF/CaO-Fe3O4, KF/CaO-Fe3O4-Li (Li additives), and KF/CaO-Fe3O4-Al (Al additives)—were compared. Rubber seed biodiesel was produced via the transesterification process under subcritical methanol conditions with nanomagnetic catalysts. The experimental results indicated that the KF/CaO-Fe3O4-Al nanomagnetic catalyst produced the highest FAME yield of 86.79%. The optimum conditions were a 28:1 molar ratio of methanol to RSO, 1.5 wt % catalyst, and 49 min reaction time. Al additives of KF/CaO-Fe3O4 nanomagnetic catalyst enhanced FAME yield without Al up to 18.17% and shortened the reaction time by up to 11 min.
An Application of the New Environmental Paradigm (NEP) Scale in a Greek Context
Authors: Ntanos Stamatios , Kyriakopoulos Grigorios , Skordoulis Michalis , Chalikias Miltiadis , Arabatzis Garyfallos
Published: January 2019

Measuring and analyzing public perceptions of the environment are becoming core elements in promoting environmental sustainability, which is a key goal to be achieved. The New Ecological Paradigm Scale (NEP) is used as a unidimensional measure of environmental attitudes as it is developed in order to measure the overall relationship between humans and the environment. A high NEP score is associated with high ecocentric orientation. This research aims to measure and analyze citizens’ NEP score in a Greek area. Overall, the statistical analysis verified the existence of the NEP subscales, indicated increased environmental awareness among the respondents and revealed that the respondents’ NEP score is correlated with the area of residence. Furthermore, the NEP score is correlated at a statistically significant level with respondents’ willingness to pay for renewable energy expansion.
A Methodology for Determination and Definition of Key Performance Indicators for Smart Grids Development in Island Energy Systems
Authors: Pramangioulis Dionysios , Atsonios Konstantinos , Nikolopoulos Nikos , Rakopoulos Dimitrios , Grammelis Panagiotis , Kakaras Emmanuel
Published: January 2019

There is a growing interest over the last decades in the field of autonomous island grids that is driven mainly by climate reasons. The common objective among the members of the European Union (EU) is the increase of Renewable Energy Sources (RES) penetration in the energy mixture, as well as turning the grid into a smart grid. Consequently, more and more state-of-the-art solutions are being proposed for the electricity generation and the optimization of the energy system management, taking advantage of innovations in all energy related sectors. The evaluation of all available solutions requires quantitative assessment, through the adoption of representative Key Performance Indicators (KPIs) for the projects that are related to smart grid development in isolated energy systems, providing the relevant stakeholders with a useful comparison among the proposed solutions. The evaluation approach that is described in this paper emphasizes the role of the various stakeholder groups who face the proposed solutions by different points of view. Apart from the domains of interest that are also observed in previous approaches, the proposed list also contains a set of legal KPIs, since the regulatory framework can either represent a serious barrier or grant a strong incentive for the implementation of state-of-the-art energy technology and grid management solutions in different countries.
Modeling and Simulation Studies Analyzing the Pressure-Retarded Osmosis (PRO) and PRO-Hybridized Processes
Authors: Chae Sung Ho , Kim Young Mi , Park Hosik , Seo Jangwon , Lim Seung Ji , Kim Joon Ha
Published: January 2019

Pressure-retarded osmosis (PRO) is viewed as a highly promising renewable energy process that generates energy without carbon emissions in the age of the climate change regime. While many experimental studies have contributed to the quest for an efficiency that would make the PRO process commercially viable, computational modeling and simulation studies have played crucial roles in investigating the efficiency of PRO, particularly the concept of hybridizing the PRO process with reverse osmosis (RO). It is crucial for researchers to understand the implications of the simulation and modeling works in order to promote the further development of PRO. To that end, the authors collected many relevant papers and reorganized their important methodologies and results. This review, first of all, presents the mathematical derivation of the fundamental modeling theories regarding PRO including water flux and concentration polarization equations. After that, those theories and thermodynamic theories are then applied to depict the limitations of a stand-alone PRO process and the effectiveness of an RO-PRO hybridized process. Lastly, the review diagnoses the challenges facing PRO-basis processes which are insufficiently resolved by conventional engineering approaches and, in response, presents alternative modeling and simulation approaches as well as novel technologies.
Acknowledgement to Reviewers of Forests in 2018
Authors:   Forests Editorial Office
Published: January 2019

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Use of Chicken Feather Peptone and Sugar Beet Molasses as Low Cost Substrates for Xanthan Production by Xanthomonas campestris MO-03
Authors: Ozdal Murat , Başaran Kurbanoglu Esabi
Published: January 2019

Xanthan gum is one of the polysaccharides most commonly used in a broad range of industries (food, cosmetics, pharmaceutical, etc.). Agro-industrial by-products are being explored as alternative low-cost nutrients to produce xanthan gum by Xanthomonas campestris. In this study, for the production of xanthan gum, sugar beet molasses and chicken feather peptone (CFP) were used as carbon and nitrogen sources, respectively. X. campestris produced the highest level of xanthan gum (20.5 g/L) at 60 h of cultivation using sugar beet molasses (40 g/L total sugar) supplemented with CFP (4 g/L) at pH 7, 200 rpm, and 30 °C. The pyruvic acid content of the xanthan gums increased with increasing CFP concentration. Compared with commercial organic nitrogen sources (tryptone, bacto peptone, and yeast extract), the highest production of xanthan gum was obtained with CFP. Moreover, among the tested peptones, the highest pyruvic acid (3.2%, w/w) content was obtained from CFP. The usage of sugar beet molasses and CFP as substrates in industries would enable a cost-efficient commercial production. These results suggest that sugar beet molasses and CFP can be used as available low-cost substrates for xanthan gum production by X. campestris.
Multi-Topology Routing Algorithms in SDN-Based Space Information Networks
Authors: Meng Xiangli , Wu Lingda , Yu Shaobo
Published: January 2019

Aiming at the complex structure of the space information networks (SIN) and the dynamic change of network topology, in order to design an efficient routing strategy, this paper establishes a SIN management architecture based on Software-defined Networking (SDN). A routing algorithm flow of the spatial information network based on a snapshot sequence is designed. For different spatial tasks with different Quality of Service (QoS) requirements, the concept of integrated link weight is proposed. The Warshall–Floyd algorithm is used to design the optimal routing strategy. A Task-oriented Bandwidth Resource Allocation (TBA) algorithm is proposed for multiple spatial tasks in the same link. Simulation results show that the algorithm can effectively guarantee the priority transmission of important tasks and avoid the unnecessary waste of bandwidth resources.