bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and anatomical characteristics of road traffic injuries in a metropolitan area. The fifth report: mortality of victims as a practical implementation of clinical outcome risks
Authors: Guriev S. O. , Kushnir V. A. , Solovyov O. S.
Published: January 2024

Objective. To identify and verify the risks of negative outcomes of the trauma process in victims with road traffic injuries as the most severe medical and health consequences of an emergency.

Materials and methods. The mortality rates of victims with road traffic injuries in a metropolitan area were studied using the method of full–scale modelling. The scope of the study was 1139 observations of road traffic injuries. The actual research material was analysed using parametric and non–parametric statistical methods.

Results. It was found that the mortality rate of victims with road traffic injuries in a metropolitan area is 4.39%. The mortality rate of men is higher (4.97%) than that of women (3.38%). The highest mortality rates are observed in the age groups over 70 years old – 16.41% and under 20 years old – 8.11%. The mortality rate for drivers is 3.02%, for passengers – 1.56%, and for pedestrians – 7.62%. In the total study population and among all road users, the highest mortality rates were observed for abdominal injuries, followed by pelvic injuries.

Conclusions. The mortality rate of victims with road traffic injuries in a metropolitan area is 4.39% and depends on the sign of participation in traffic and clinical factors, namely, the volume and clinical and nosological form of the lesion and the severity of the injury. Active road users (pedestrians) have the highest mortality rate (7.62%), and passive road users (passengers) have the lowest (1.56%).
Organisation of the educational process in the 2nd year of internship in surgery at Odesa National Medical Univesity
Authors: Mishchenko V. V. , Koichev E. A. , Mishchenko V. P. , Holovatyuk–Yuzephpolska I. L.
Published: January 2024

Organisation of the educational process in the 2nd year of internship in surgery at Odesa National Medical Univesity
Igor Anatolyevich Lurin (to the 55th anniversary)
Authors: Board Editorial
Published: January 2024

Igor Anatolyevich Lurin (to the 55th anniversary)
Análisis de Audiencia y Preferencias para programación matutina en la TV pública de Nuevo León (Canal 28)
Authors: Mancha Torres Gloria L , Céspedes del Fierro Selene
Published: January 2024

El objetivo de este trabajo, que es de corte cuantitativo, es realizar un Análisis de Audiencia y Preferencias para Programación Matutina del Canal 28 de la televisión pública de Nuevo León, México, buscando responder a tres principales cuestionamientos: ¿quién mira la televisión por las mañanas?, ¿qué tanto la gente identifica el canal 28 y su programación?, y ¿qué contenido le gustaría a la gente mirar en canal 28 por la mañana? 

Dado que no existen estudios de este tipo para Canal 28, el presente trabajo busca aportar conocimiento que pueda ser aplicado por el Canal en beneficio de su audiencia. La recopilación de datos se realizó a través de una Encuesta por internet a personas mayores de 18 años en el área metropolitana de Monterrey. El tamaño de muestra fue de 650 personas.

Los resultados nos permiten observar que existe entre los ciudadanos un marcado desconocimiento de TV Nuevo León, Canal 28 y poca disposición para sintonizar alguno de sus programas; que son los adultos mayores quienes acostumbran, en mayor medida, mirar Canal 28 y que además, son quienes tienen mayor conocimiento de la programación de este canal; y que un área de oportunidad es sin duda, comenzar a migrar o duplicar sus programaciones en plataformas digitales para las nuevas generaciones. En cuanto a las preferencias de programación, los programas más mencionados fueron Noticieros, programas de Entretenimiento/Revista, Deportes alternativos, programas de Historia y Cultura General y programas de Música/Arte. En temas específicos, las opciones mejor evaluadas fueron: Cocina Mexicana, Salud, Nutrición, Leyendas y Tradiciones, Curso de Finanzas, Bolsa de Trabajo y Curso de Yoga. En un análisis por edad, hay opciones de programación que se mantienen y otras muy específicas a los intereses de cada grupo de edad.
Teacher Classifications of Implementing Classroom Movement Integration in Elementary Schools
Authors: Moon Jongho , Lee Dongwoo
Published: January 2024

We explore the multifaceted role of elementary school teachers in implementing classroom-based Movement Integration (MI) to promote physical activity among children. While many factors and barriers can influence the successful execution of MI activities, understanding the nature and use of MI video resources remains unexplored. Therefore, we focus on exploring elementary school teachers’ MI practices and their engagement with MI in order to identify teachers’ different typologies. The research involved a mixed-methods design, predominantly qualitative, with teachers from a specific demographic. We identified three distinct teacher typologies: High-Engagement Providers (HEPs), Strategic Providers (SPs), and Reluctant Providers (RPs). The HEPs were highly engaged, incorporating multiple MI activities daily and effectively managing student behavior and motivation. Conversely, SPs acknowledged classroom management issues but attributed successful MI implementation to students’ self-control and effective routines. However, RPs expressed reservations due to management challenges and potential distractions from academic tasks. Regardless of typology, all teachers accentuated the need for professional development opportunities to improve MI practices. We recommend providing training and support to enhance teacher self-efficacy in implementing MI and addressing challenges. Even though limitations exist regarding participant demographics, our study offers an initial in-depth exploration of teachers’ MI implementation and may pioneer future studies.
Children s Multicultural Education through Local-Dance Activities: Teacher s Thoughts and Involvement
Authors: Yetti Elindra , Syarah Erie Siti , Mutiara Sari Kartika , Oktarini Sally , Nurdyana Tutung , Syakhruni Syakhruni , Puspawati Gusti Ayu Made , Jovanka Della Raymena
Published: January 2024

Multicultural education for early childhood is important because it is considered a central idea in its contribution to the rapprochement of contemporary society. This qualitative study examines the thoughts of 71 teachers regarding their thinking and involvement in educational dance based on local cultural interventions as a new form of multicultural education for children. Observations of the multicultural learning process in several Kindergartens and Elementary Schools as well as in-depth interviews with teachers of children aged 6-9 years are data collection techniques to identify needs and problems related to multicultural education. These findings describe four categories related to multicultural education for children that can become a provision for 21st-century skills and illustrate the importance of educational dance as a tool for children's cultural dexterity in the future. Further research is recommended to develop products that can increase tolerance for diversity in children.
Enhancing Arabic Speaking Skills In Traditional Pesantren
Authors: Maghfurin Ahmad , Husna Moh. Ahsanul , Cholid Nur , Mazlan Nurul Asma , Jumiati
Published: January 2024

Proficiency in the Arabic language is imperative in the context of Islamic education. However, the effective study of Arabic remains a challenge, hindering students' abilities to engage with Islamic texts and communicate in Arabic-speaking environments. Focusing on Pesantren Raudhatul Ulum-Pati, this study investigates the strategies and challenges associated with enhancing Arabic speaking skills in traditional Islamic boarding schools (Pesantren). Specific teaching techniques employed by instructors at this pesantren, aimed at improving students' Arabic speaking abilities, as well as the challenges impeding fluency, were examined through a qualitative research design, including classroom observations and interviews with teachers, administrators, and students. The outcomes highlight the importance of innovative methods and shed light on issues such as a lack of exposure to Arabic-speaking environments. The program implemented in this pesantren serves as an exemplary model for other traditional Islamic boarding schools seeking to elevate their students' proficiency in the Arabic language. The findings of this study hold significant implications for all traditional Islamic boarding schools (pesantren) in Indonesia.
Mathematical Modeling for a CHIKV Transmission Under the Influence of Periodic Environment
Authors: El Hajji Miled , Alharbi Nawaf Salah , Alharbi Mohammed H.
Published: January 2024

We studied a simple mathematical model for the chikungunya virus (CHIKV) spread under the influence of a seasonal environment with two routes of infection. We investigated the existence and the uniqueness of a bounded positive solution, and we showed that the system admits a global attractor set. We calculated the basic reproduction number R0 for the both cases, the fixed and seasonal environment which permits us to characterise both, the extinction and the persistence of the disease with regard to the values of R0. We proved that the virus-free equilibrium point is globally asymptotically stable if R0≤1, while the disease will persist if R0>1. Finally, we gave some numerical examples confirming the theoretical findings.
Effect of Red Spinach Juice + Fe Tablets on Increased Hemoglobin Levels in Pregnant Women
Authors: Mariati  , Mizawati Afrina , Maigoda Tonny C
Published: January 2024

Anemia during pregnancy is one of the most common abnormalities in pregnant women in Indonesia. The prevalence of anemia in pregnant women in Indonesia is 48.9%. The iron supplementation program is an effort that has been made by the Indonesian government to prevent anemia. To determine the effect of giving red spinach juice on increasing hemoglobin levels in third-trimester pregnant women. This type of research uses quantitative methods with quasi-experimental research with the two-group approach. The experimental group consumed red spinach juice + Fe tablets and the control group only drank Fe tablets. The results showed that there was an effect of giving red spinach juice + Fe tablets to increasing hemoglobin levels and there was a difference in increasing hemoglobin levels in the group given red spinach juice + Fe tablets and Fe tablets only. There is a relationship between parity and an increase in hemoglobin levels, but there is no relationship between age and education and an increase in hemoglobin levels. Intervention and parity variables were the most influential variables in increasing the hemoglobin level of pregnant women in PMB Bengkulu City. Results: There is an effect of giving red spinach juice + Fe tablets to the increase in hemoglobin levels of pregnant women.
Partnership Strategy of Course and Training Institutions in Guaranteing the Quality of Education with the World of Work Industry: A Review
Authors: Susilowati Rini
Published: January 2024

The role of the Unna Course and Training Institute (LKP) is very necessary in obtaining competent skills to meet the needs of society, especially in the field of beauty. LKP Unna aims to be able to produce graduates who are competent, efficient, and able to compete in the Business World, Industry, and Work World (DUDIKA) in the field of beauty. This research method is a review method. Journal review method by comparing one journal with another journal in the sense of integrating the results of analysis of research journals based on the similarities and differences of each and then providing new conclusions. This research aims to create an effective strategy for LKP Unna to ensure the quality of graduates so they can compete in the labor market. The government implements various policies so that the quality of Course and Training Institutions (LKP) is guaranteed, including LKP must have; NPSN; Accredited; Have Institutional Performance Assessment and process quality assurance, Course and Training Institutions ( LKP) must implement curriculum standards using: the Indonesian National Framework (KKNI), Graduate Competency Standards (SKL), and Project Based Learning (PBL) based curriculum and translated into Learning Implementation Plans (RPP) and Teaching Materials. The partnership strategy used is to be equal and in line with the needs of the world of work industry, the aim of which is to penetrate the labor market both nationally and internationally. In the industrial world of work, several aspects can collaborate including curriculum, instructors, marketing, mentoring, apprenticeships, and job placement of LKP graduates in related industrial worlds
DOI DESATIVADO
Authors: Ghins Michel
Published: January 2024

DOI DESATIVADO
DOI DESATIVADO
Authors: Dutra Luiz Henrique de Araújo
Published: January 2024

DOI DESATIVADO
DOI DESATIVADO
Authors: Soto Cristián
Published: January 2024

DOI DESATIVADO
A VIVÊNCIA DA MONITORIA DO PIBASIC COM ESTUDANTES PÚBLICO-ALVO DA EDUCAÇÃO ESPECIAL NA EDUCAÇÃO BÁSICA
Authors: PEREIRA RAYANE RIBEIRO , RAMOS NICOLLE MELO , BARCA ANA PAULA DE ARAÚJO , GODIM SUELEN TAVARES
Published: January 2024

O presente trabalho deriva das vivências e observações de estudantes de graduação, participantes da monitoria do PIBAsic, dentro da Escola de Aplicação da UFPA, entre os meses de março a novembro de 2022. As informações foram coletadas por meio da análise dos relatos produzidos e registrados no documento Ficha de Observação e Acompanhamento Diário em Sala de Aula, elaborado pela
Coordenação de Educação Inclusiva e preenchido pelos(as) monitores(as) a partir das vivências na sala de aula do ensino regular. Participaram diretamente desta pesquisa dois estudantes com Transtorno do Espectro Autista (TEA) matriculados em turmas dos Anos Iniciais do Ensino Fundamental da Escola de Aplicação.
PROPOSTA DE UM JOGO ELETRÔNICO EDUCATIVO PARA O APRENDIZADO DA LÍNGUA INGLESA
Authors: CORTINHAS LUCAS MEIRELES , MOREIRA CAIO CARVALHO
Published: January 2024

Os jogos são uma alternativa interessante quando se trata de aprendizado de uma nova língua, pois possuem interatividade e o jogador ainda expande seu vocabulário. Assim os jogos se tornam uma alternativa bastante chamativa para auxiliar os alunos do ensino básico das escolas públicas na compreensão da língua inglesa. Este artigo tem como objetivo propor um jogo digital para auxiliar o aprendizado da língua inglesa voltado pro ensino básico, contando com 4 missões, uma delas com interação por reconhecimento de voz. O desenvolvimento do jogo mostrou-se satisfatório, trazendo diálogos do cotidiano, interações e uma forte presença do teor lúdico.
Apert Syndrome: A Case Report
Authors: Renardy Reza Razali , Munawar Adhar Lubis
Published: January 2024

Background: Apert syndrome is a type 1 acrocephalosyndactyly, a rare syndrome characterized by the presence of multiple craniosynostoses, dysmorphic facial manifestations, and syndactyly of hand and feet. It affects 1:100.00 of birth and is the second most common of syndromic craniosynostosis. Molecular genetic tests that identify the heterozygous pathogenic variant in FGFR2 genes - identical with Apert syndrome cost too high to be applicable in developing countries. Therefore, the diagnosis of Apert syndrome should be suspected from the clinical findings. Three cases from the Community of Indonesian Apert Warrior Group were collected. These series were based on medical and surgical records. We obtained the patient characteristics from the phenotypic manifestations only. Case report: We present a case of a newborn baby girl, with similar anatomical findings, such as skull shape abnormality, midface hypoplasia, intraoral disfigurement, and hands and feet deformities that resemble Apert Syndrome. Our series presents similar Apert syndrome characteristics, such as typical craniofacial dysmorphic with symmetrical syndactyly of both upper and lower extremities. These clinical findings are essential to establish an initial diagnosis of Apert Syndrome.
Dual Role of Clinician Managers in Healthcare - Challenges and Opportunities
Authors: Ahsana Nazish
Published: January 2024

Background: Clinician managers can play a crucial role in healthcare organizations, including hospitals, by combining their clinical expertise with managerial responsibilities. They bring valuable insights and firsthand experience of patient care to managerial positions, contributing to improved patient outcomes and hospital performance. However, they face unique challenges that require careful attention and solutions. Aim: This review aims to critically discuss the role of clinicians as managers, the challenges that they face, and how they exercise their influence in hospital settings. Key findings: The role of clinicians as managers is critical for effective leadership and delivery of high-quality patient care. Described as a two-way window, clinician managers bridge the gap between medicine and management by combining clinical expertise with managerial skills in a hybrid leadership approach. Studies have shown a positive impact on hospital performance, including enhanced quality care, improved patient outcomes, and potentially better financial performance. In addition, they play a vital role in fostering interdisciplinary collaboration and boosting staff engagement. However, challenges such as identity conflicts, and limited formal training, are present, especially for first-time managers. Conclusion: Adapting to the dual role of clinician and manager demands a mindset shift and the development of new skills, necessitating strategic support. This includes leadership education, organizational support, mentoring, and collaborative models to empower clinician managers. Targeted training programs, formal mentoring, and peer support networks equip them with essential skills, while workload management, well-being initiatives, and a culture of balance foster success and growth.
Individual Treatment Trial of PIGV-Associated Mabry Syndrome with D-Mannose in a Young Child
Authors: Marta Agnes Somorai , Annabelle Arlt , Peter Krawitz , Jochen Baumkötter , Volker Mall
Published: January 2024

We describe the first individual treatment trial with D-mannose in a young girl with PIGV-CDG. PIGV-CDG belongs to the GPI anchor deficiencies leading to intellectual disability, dysmorphic features, epilepsy, and, less frequently, organ malformations. A hallmark of the GPI anchor deficiencies is the elevated serum alkaline phosphatase (AP). Our patient carried the germline homozygous PIGV variant c.1022C>A, p. (Ala341Glu), the most commonly reported pathogenic variant leading to PIGV-CDG so far. We aimed to improve the impaired enzymatic function of PIGV through elevated substrate levels by giving D-mannose orally. We monitored the clinical status, developmental progress as well as serum AP levels. Our patient experienced no side effects. Standardized developmental testing showed better developmental progress during the 21-month treatment period with D-mannose than in the 12 months following the discontinuation of treatment. The D-Mannose treatment might have had a positive effect on the development of our patient with PIGV-CDG.
Realist hands-on learning approach and its contributions to learners’ conceptual understanding and problem-solving skills on solid geometry
Authors: Tessema Girma , Michael Kassa , Areaya Solomon
Published: January 2024

This study aimed to examine the application of a realist hands-on learning approach and its contributions to optimizing the solid geometry conceptual understanding and problem-solving skills of students. It employed a non-equivalent pre-/post-test quasi-experimental research design. The results showed that there was a statistically significant mean difference between the intervention group and the comparison group, with an effect size of d=.825 for the students’ solid geometry conceptual understanding and d=.930 for the students’ problem-solving skills. Furthermore, a strong correlation was observed between students’ conceptual understanding and problem-solving skills in solid geometry, with an r2 of .6413. These indicate that the use of a realist hands-on approach positively contributes to optimizing learners’ conceptual understanding and problem-solving skills. It also provides contextually relevant learning opportunities; therefore, it is recommended that teachers and concerned bodies employ a realist hands-on approach to make solid geometry learning concrete and practical.
The Power of Peers: Understanding the Link Between Social Support and Grit Among Working Students
Authors: Lase Poppy Dyan Jelita , Wibowo Doddy Hendro
Published: January 2024

In the modern academic sphere, students often juggle work and studies, leading to challenges in maintaining academic progress. A key trait associated with managing these challenges is grit, defined as long-term perseverance and passion for goals. This research investigated the correlation between peer social support and grit among part-time working students in Salatiga, Central Java. Utilizing Multi-stage Snowball Sampling for participant selection, the study collected data from 120 undergraduate students, employing the Social Support Scale and the Grit Scale. Statistical analysis confirmed a significant positive relationship between peer social support and grit. Given the importance of grit in academic and professional outcomes, and the pivotal role of peer social support in cultivating it, this study underscores the need for educational interventions that enhance social support structures for part-time working students. The findings offer vital insights for educators and policymakers, advocating for the integration of peer-driven support systems in academic settings.
Peramalan Harga Minyak Goreng di Kalimantan Timur Menggunakan Model Hybrid Time Series Regression Quadratic – Neural Network
Authors: Wahyuni Risa Kristia , Wahyuningsih Sri , Siringoringo Meiliyani
Published: January 2024

A hybrid model is a combination of two or more forecasting methods. One of hybrid model that can be used in forecasting is Time Series Regression (TSR) Quadratic – Neural Network (NN). TSR Quadratic can be used in time series data that contains quadratic trend patterns, namely an increase or decrease that forms a curved or parabolic line NN is a method that has characteristics similar to biological neural networks in conducting data pattern recognition. This study was aimed to obtain a hybrid model of TSR quadratic-NN to forecast cooking oil prices in East Kalimantan and obtain forecasting results based on the best model. The results showed that the TSR Quadratic-NN hybrid model with 3 neurons in the hidden layer was the best model with a MAPE of 2.51368%. The forecasting results based on this model showed that cooking oil prices in East Kalimantan from January to December 2023 showed an increase
Peran Arsitek dalam Pelestarian Objek di duga Cagar Budaya Wilayah Samarinda Kalimantan Timur
Authors: Mulyani  , Kholifah Nur Asriatul , Azizah Anisah , Nur Azizah Amelia Dwi , Antaresti Afriza Rizki , Amalia Putri Nabeela , Tamama Vinie , Gumilang Syarif Saddam
Published: January 2024

Indonesia memiliki beragam budaya dalam setiap daerah, keberagaman ini menciptakan berbagai sejarah serta bentuk atau ciri khas dari sebuah daerah tersebut.  Salah satu daerah yang memiliki berbagai macam cerita terdahulu adalah Samarinda tepatnya berada di Samarinda Seberang dengan terbentuknya atau terbangunnya sebuah bangunan yang memiliki filosofi maupun cerita nya masing-masing. Semakin berkembangnya pembangunan-pembangunan pada wilayah Samarinda membuat bangunan-bangunan terdahulu semakin tidak diperhatikan. Namun, hal ini ditindaklanjuti oleh pemerintah wilayah Samarinda untuk melakukan pelestarian terhadap sejarah yang telah terjadi di masa lampau. Penelitian ini bertujuan untuk 1) Menentukan objek bangunan bersejarah yang di duga belum menjadi cagar budaya, 2) Mengetahui sejarah terbangunnya sebuah bangunan pada wilayah tersebut, 3) Menentukan upaya pelestarian yang akan digunakan pada bangunan. Penelitian ini merupakan pengembangan dalam pelestarian sebuah bangunan bersejarah yang akan mengacu pada pola pikir untuk melakukan upaya-upaya pelestarian bangunan sejarah. Kesimpulan dari perencanaan ini adalah 1) Penentuan Objek bersejarah serta fungsi disesuaikan dengan sejarah terdahulu, 2) Awal mula sejarah bangunan ini diketahui melalui sejarah seseorang melalui salah satu alat transportasi, 3) Bangunan bersejarah membutuhkan beberapa upaya pelestarian yaitu dengan melakukan rekonstruksi yang merupakan upaya dengan memperbaiki kerusakan-kerusakan yang telah terjadi tanpa merubah bentuk asli sebuah bangunan.
 
Kata Kunci: Sejarah, Bangunan, Cagar Budaya, Pelestarian
The Development of the Vulnerability Index (VI) using Principal Component Analysis (PCA)
Authors:   School of Geomatic Science and Natural Resources, College of Built Environment,Universiti Teknologi MARA, 40450, Shah Alam,Selangor, MALAYSIA, Salleh Siti Aekbal , Isa Nurul Amirah ,   Faculty of Asia Built Environment,University of Geomatika Malaysia, Setiawangsa,54200, Kuala Lumpur, MALAYSIA, Siman Nurul Aida ,   As White Global Sdn. Bhd, Suite, 10.1 Level 10,Centrepoint North MidValley City,58000, Kuala Lumpur, MALAYSIA, Zakaria Nur Hidayah ,   School of Geomatic Science and Natural Resources, College of Built Environment,Universiti Teknologi MARA, 40450, Shah Alam,Selangor, MALAYSIA, L. Pintor Lynlei ,   Ecosystems Research and Development Bureau (ERDB), Department of Environment and Natural Resources,College, Laguna, PHILIPPINES, Yaman Rostam ,   Institute of Biodiversity and Sustainable Development,Universiti Teknologi MARA, 40450, Shah Alam, Selangor, MALAYSIA, Che Dom Nazri ,   Faculty of Health Science,Universiti Teknologi MARA, 40450, Shah Alam, Selangor, MALAYSIA
Published: January 2024

Climate change elevates the rate of emergence of urban heat islands (UHIs), especially in the tropics. UHIs severely affect human comfort and health. Many studies have suggested that urban areas should be properly mitigated or planned. To cope with this, it is best to present the issue using easy-to-understand approaches to allow for better decision-making, especially during urban planning. Based on the information, adaptations and mitigation strategies can be suggested in order to reduce the impact. Hence, this research was aimed at determining the heat vulnerability index (HVI) of urban areas. This study was conducted in Malaysia in the Klang Valley, a tropicalcity with a complex urban morphology. Remote sensing techniques were employed to extract and derive the spatial index values for exposure, sensitivity, and adaptive capacity. A principal component analysis (PCA) was used to estimate the vulnerability as well as to generate the HVI. The most vulnerable districts were found to be Petaling (1.00), Kuala Lumpur (0.99), and Putrajaya (0.95). Kuala Lumpur had a level of exposure that was high (0.56), a level of sensitivity that was high (0.84), and capacity to adapt that was low (0.54), while Petaling had a high exposure value (0.56), very high sensitivity (1), and high adaptive capacity (0.72). A Pearson’s correlation (r) test also revealed that the variables used were highly correlated. From the preliminary findings, the vulnerability of the population to high temperatures in the Klang Valley can be identified to help develop adaptative plans that are targeted as a response to rapid warming in the future in Malaysia.
Доказательство стереоспецифичности цитопротекторного и антидепрессантоподобного действия ГТС-301, димерного дипептидного миметика нейротрофина-3
Authors: Сазонова Нелля Михайловна , Тарасюк Алексей Валерьевич , Мельникова Марина Валерьевна , Жанатаев Ильяс Алиевич , Логвинов Илья Олегович , Николаев Сергей Владимирович , Никифоров Дмитрий Михайлович , Антипова Татьяна Алексеевна , Поварнина Полина Юрьевна , Гудашева Татьяна Александровна , Середенин Сергей Борисович
Published: January 2024

Ранее нами на основе β-изгиба 4-й петли нейротрофина-3 был сконструирован и синтезирован его миметик, гексаметилендиамид бис-(N-моносукцинил-L-аспарагинил-L-аспарагина) (ГТС-301LL), проявивший свойства полноразмерного нейротрофина. ГТС-301LL активировал TrkC и TrkB рецепторы, обладал защитным действием на клетках HT22 в условиях окислительного стресса в концентрациях 10–5 – 10–12 М и антидепрессантоподобной активностью в тесте вынужденного плавания на мышах в дозах 10 – 40 мг/кг внутрибрюшинно. Для выявления стереоспецифичности эффектов ГТС-301 в настоящей работе синтезированы его LD-, DL- и DD-стереоизомеры и изучены их цитопротекторные и антидепрессантоподобные свойства в тех же условиях, что и для ГТС-301LL. Установлено, что оба вида активности исчезали при переходе от LL- к DL- и DD-стереоизомерам и сохранялись при переходе к LD-стереоизомеру. Таким образом, установлена стереоспецифичность фармакологических эффектов ГТС-301 по N-концевому остатку аспарагина, что свидетельствует о его ключевой роли во взаимодействии с рецептором.
Изучение процесса прессования таблеток с N-бутил-N-метил-1-фенилпирроло[1,2-a]пиразин-3-карбоксамидом (ГМЛ-3) с помощью методов математического моделирования
Authors: Маркеев Владимир Борисович , Тишков Сергей Валерьевич , Блынская Евгения Викторовна , Алексеев Константин Викторович
Published: January 2024

N-Бутил-N-метил-1-фенилпирроло[1,2-a]пиразин-3-карбоксамид (ГМЛ-3) является оригинальной молекулой, разработанной в Научно-исследовательском институте фармакологии имени В. В. Закусова. Молекула ГМЛ-3 обладает одновременно анксиолитическим и антидепрессивным эффектом, что делает перспективной разработку таблеток на ее основе. Оптимизация процесса прессования в настоящее время является одной из актуальных задач фармацевтической промышленности, поскольку данный технологический этап оказывает существенное влияние на распадаемость таблеток и высвобождение активной фармацевтической субстанции. Для исследования процесса прессования таблеток ГМЛ-3 использованы модели Хеккеля и Куенца–Лойенбергера. Сравнение этих моделей проведено с целью выбора наиболее достоверно описывающей процесс прессования таблеток ГМЛ-3, таблетируемых из гранул. Использовались гранулы с поливинилпирролидоном (ПВП) и гидроксипропилметилцеллюлозой (ГПМЦ) в качестве связующего вещества.
Нейропротекторные свойства оригинальных лигандов транслокаторного белка 18 кДа (TSPO) соединений ГМЛ-1 и ГМЛ-3
Authors: Мокров Григорий Владимирович , Николаев Сергей Владимирович , Антипова Татьяна Алексеевна , Гудашева Татьяна Александровна , Середенин Сергей Борисович
Published: January 2024

Исследована нейропротекторная активность оригинальных лигандов транслокаторного белка 18 кДа (TSPO) соединений ГМЛ-1 и ГМЛ-3 in vitro. Окислительный стресс, вызванный H2O2 (1,5 мМ), приводил к достоверному снижению жизнеспособности клеток гиппокампа мышей линии НТ-22. Соединения ГМЛ-1 и ГМЛ-3 защищали клетки от гибели при внесении как за 24 ч до, так и сразу после повреждения перекисью водорода, в концентрациях 10–6 – 10–9 М.
Implementasi Budaya Korea Dalam Mengembangkan Karakter Anak Usia Dini
Authors: Munawaroh Munawaroh , Fauzi Fauzi
Published: January 2024

Generasi muda Indonesia, yang mencakup anak-anak dan remaja, kini menunjukkan preferensi yang lebih tinggi terhadap budaya Korea dibandingkan budaya lokal mereka sendiri. Situasi ini perlu digunakan sebagai salah satu strategi untuk memberikan pendidikan. Tujuan penelitian ini adalah upaya mengimplementasikan budaya korea dalam pembentukan karakter anak usia dini. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Data penelitian adalah artikel, buku, dan sumber referensi lain yang merepresentasikan budaya Korea. Adapun data yang didapatkan menggunakan literatur review. Analisis data menggunakan teknik induktif. Hasil penelitian menunjukkan bahwa dari beberapa budaya Korea dapat diimplementasikan pada anak dalam upaya mengembangkan karakter anak usia dini di Indonesia. Beberapa nilai yang dapat diambil dari budaya Korea dan diterapkan pada anak-anak di Indonesia meliputi disiplin, menghargai orang tua, kerja sama, solidaritas, dan peduli lingkungan. Implikasi penting dari penelitian ini adalah nilai-nilai pendidikan karakter dari budaya Korea dapat diterapkan dalam pendidikan di Indonesia, khususnya pendidikan karakter anak anak usia dini.
Validitas Video Interaktif dengan Pendekatan Etnopedagogik Berbasis Saintifik untuk Siswa Sekolah Dasar
Authors: Safitri Erna Retna , Raharjo Makmum , Harlin Harlin
Published: January 2024

Penelitian bertujuan untuk menganalisis tingkat validitas video interaktif dengan pendekatan etnopedagogik berbasis saintifik dalam meningkatkan pemahaman siswa Sekolah Dasar pada Mata Pelajaran Matematika. Penelitian dilakukan dengan menggunakan pendekatan research and development Adapun model pengembangan yang digunakan adalah model ADDIE. Dalam penelitian ini tahapan pengembangan diawali dengan tahapan analisis dan desain. Tahap berikutnya adalah tahapan pengembangan. Pengumpulan data dilakukan dengan teknik angket. Teknik analisis data dilakukan untuk untuk menentukan validitas video interaktif yang dikembangkan. Validator memberi tanggapan secara secara kuantitatif dan kualitatif. Dari hasil uji validitas mengggunakan uji Gregory diperoleh koefisien validitas yaitu 0,90. Hal ini menunjukkan bahwa setiap aspek dari video interaktif ini valid dan dalam kategori sangat tinggi. Dapat disimpulkan bahwa video interaktif sangat layak digunakan sebagai media pembelajaran bagi siswa Sekolah Dasar dalam mata pelajaran matematika sub tema jaring-jaring kubus
Evaluasi Kinerja Pelayanan Pegawai Kantor Camat Padangsidimpuan Utara Menggunakan Pendektan Fuzzy Inference System Sugeno
Authors: Subarja Roy Efendi , Hendrik Billy
Published: January 2024

Penelitian ini bertujuan untuk mengevaluasi kinerja pelayanan pegawai di Kantor Camat Padangsidimpuan Utara dengan memanfaatkan Pendekatan Fuzzy Inference System Sugeno. Metode ini memungkinkan untuk mengukur dan menganalisis berbagai aspek kinerja pelayanan, termasuk efisiensi, responsifitas, dan kepuasan masyarakat. Data evaluasi dikumpulkan melalui survei kepada stakeholder terkait dan dianalisis menggunakan model Fuzzy Inference System Sugeno yang telah dikembangkan. Penelitian ini menghasilkan hasil evaluasi yang lebih akurat dan dapat memberikan rekomendasi yang lebih terperinci untuk pengambilan keputusan terkait peningkatan kinerja pelayanan. Temuan dari penelitian ini dapat menjadi landasan bagi pihak terkait di Kantor Camat Padangsidimpuan Utara untuk mengimplementasikan strategi dan kebijakan yang bertujuan untuk meningkatkan kualitas pelayanan. Selain itu, metodologi yang digunakan dalam penelitian ini juga dapat diadaptasi dan diterapkan dalam evaluasi kinerja pelayanan di kantor-kantor Camat lainnya atau lembaga pemerintah lainnya untuk memperoleh informasi yang lebih akurat dan mendalam terkait dengan kinerja pelayanannya.
Student Perception of Mobile Legends Bang Bang to Improve Vocabulary Mastery
Authors: Balqish Adinda Nur , Hadi Muhammad Sofian
Published: January 2024

Berkembang pesatnya tekhnologi dan ilmu pengetahuan, menyebabkan berbagai aspek dalam kehidupan mengaplikasikan penggunaan teknologi didalamnya. Termasuk dalam aspek pendidikan. Guru menggunakan media pembelajaran menggunakan teknologi yang banyak tersedia di internet. Game merupakan salah satu aplikasi yang banyak digunakan guru dalam menunjang pembelajaran. Mobile Legends Bang Bang adalah game yang sedang marak dimainkan oleh kalangan remaja. Oleh karena itu, penelitian ini bertujuan untuk mengetahui persepsi siswa terhadap Mobile Legends Bang Bang dalam meningkatkan penguasaan kosakata Bahasa Inggris. Penelitian ini mengambil data kualilitatif dengan metode survey atau kuesioner dengan jumlah pertanyaan 21, yaitu 20 pertanyaan tertutup dan 1 pertanyaan terbuka, dengan responden siswa SMA dalam lingkup Tangerang dan Jakarta Selatan. Hasil dari penelitian ini menunjukkan bahwa siswa menunjukkan persepsi positif terhadap Mobile Legends Bang Bang untuk meningkatkan kosakata Bahasa Inggris.
Pengembangan Media Pembelajaran Informatika Berbasis Multimedia Interaktif Menggunakan Google Sites SMK Islamiyah Ciputat
Authors: Rahmasari Rahmasari , Efendi Yasin , Wathoni Mahbubul , Ramadi Rikaro
Published: January 2024

Materi bahan ajar informatika yang digunakan masih menggunakan papan tulis dengan metode lisan guru sehingga masih kurang menarik dan monoton. Sulit untuk menggandakan dokumen karena menggunakan media konvensional. Sarana pembelajaran berbasis multimedia interaktif masih jarang digunakan, sehingga pemanfaatan media internet sebagai sarana pembelajaran masih dirasa kurang optimal. Menghasilkan media pembelajaran informatika berbasis multimedia interaktif menggunakan google sites SMK Islamiyah Ciputat untuk mengetahui kevalidan dan kepraktisan merupakan tujuan dari penelitian ini. Metodologi penelitian ini adalah penelitian dan pengembangan (R&D) dengan menggunakan model pengembangan ADDIE, yang terdiri dari lima tahap: analisis, desain, pengembangan, implementasi dan evaluasi. Subjek penelitian ini adalah siswa kelas XI SMK Islamiyah Ciputat. Hasil penelitian yang diperoleh untuk kevalidan materi yaitu 88% dengan kategori sangat valid (SV) dan kevalidan media 96% dengan kategori sangat valid (SV). Sedangkan hasil kemenarikan yang diperoleh untuk angket respon 3 guru informatika 96,66% dengan kategori sangat menarik (SM) dan untuk angket respon siswa 98,88% dengan kategori sangat menarik (SM). Berdasarkan data tersebut dapat disimpulkan bahwa media pembelajaran informatika berbasis multimedia interaktif menggunakan google sites dinyatakan valid dan sangat menarik untuk menaikan minat belajar siswa.
Peningkatan Hasil Belajar Siswa Terhadap Pelajaran Ipa Tentang Cahaya dan Sifat-Sifatnya Dengan Metode Demonstrasi Bagi Siswa Kelas V SD Negeri 016 Perigi Raja Kecamatan Kuala Indragiri Indragiri Hilir
Authors: Meiderni Meiderni
Published: January 2024

Penelitian Tindakan Kelas ini dilatarbelakangi rendahnya ketuntasan hasil belajar IPA dan dilakukan  untuk memperbaiki proses pembelajaran yang belum optimal. Penelitian bertujuan untuk mengetahui apakah penerapan metode demonstrasi dapat meningkatkan hasil belajar siswa  pada pembelajaran IPA materi cahaya dan sifat-sifatnya kelas V SD Negeri 016 Perigi Raja Kecamatan Kuala Indragiri Kabupaten Indragiri Hilir. Pelaksanaan perbaikan dilakukan dalam dua siklus. Siklus I dilaksanakan pada tanggal  6 Januari 2021 dan Siklus II pada tanggal 11 Januari 2021. Pada pertemuan prasiklus, hasil belajar  siswa masih sangat rendah, setelah dilakukan Penelitian Tindakan Kelas, Siklus I dan Siklus II dari 18 siswa yang nilainya sesuai KKM 67 dan yang diatas KKM pada Siklus I sebanyak 13 siswa (72%) dan yang belum tuntas sebanyak 5 siswa (28%), kenyataan tersebut menunjukkan belum sepenuhnya pembelajaran Siklus I berhasil. Pada Siklus II hasil evaluasi belajar yang dicapaipun meningkat. Dari 18 siswa yang mencapai di atas KKM 67 pada Siklus II sebanyak 16 siswa (89%) siswa dan yang belum tuntas 2 orang siswa (11%). Dimana Nilai rata-rata siswa sudah mencapai 84, ini menunjukkan bahwa rata-rata nilai siswa sudah berada di atas nilai KKM 67. Dapat disimpulkan bahwa penerapan metode demonstrasi dapat meningkatkan hasil belajar siswa pada mata pelajaran  IPA materi cahaya dan sifat-sifatnya kelas V Negeri 016 Perigi Raja Kecamatan Kuala Indragiri Kabupaten Indragiri Hilir.
Analisis Beban Kerja Pada Karyawan KCU PT. Pos Indonesia (Persero) Malang
Authors: Atikah Rahmah Ayu , Rizqi Maulidyah Amalina
Published: January 2024

Sumber daya manusia adalah aspek yang berperan penting dalam sebuah organisasi atau perusahaan. Kemampuan dari seorang karyawan juga harus dapat dipahami oleh suatu organisasi terutama terkait dengan beban kerja. Beban kerja yang berlebih dapat berdampak pada fisik dan mental. KCU PT Pos Indonesia sebagai badan usaha milih negara (BUMN) telah berhasil memberikan kemampuan dan potensi yang terbaik bagi karyawannya. Tujuan dari penelitian ini yaitu melakukan kajian mengenai sebab akibat beban kerja yang dialami oleh karyawan divisi UPL dan keuangan dari KCU Pos Indonesia Malang. Penelitian ini menggunakan pendekatan kualitatif dengan bersumber pada data primer. Pengumpulan data dengan melalui observasi dan wawancara. Sumber informan sebanyak enam orang berasal dari staff keuangan dan DPL. Hasil penelitian menunjukkan bahwa penyebab beban kerja bersumber pada pengiriman berkas naskah yang tidak tepat waktu. Adanya beban kerja tersebut dapat menyebabkan adanya perasaan lelah pada karyawan. Berdasarkan hal tersebut dapat diketahui bahwa dalam penelitian ini terdapat hubungan sebab akibat dari beban kerja yang dialami oleh karyawan KCU Pos Indonesia Malang.
Presentación
Authors: Moreno Alvaro
Published: January 2024

Presentación
Illegal loot box advertising on social media? An empirical study using the Meta and TikTok ad transparency repositories
Authors: Xiao Leon Y.
Published: January 2024

Loot boxes are gambling-like products inside video games that can be bought with real-world money to obtain random rewards. They are widely available to children, and stakeholders are concerned about potential harms, e.g., overspending. UK advertising must disclose, if relevant, that a game contains (i) any in-game purchases and (ii) loot boxes specifically. An empirical examination of relevant adverts on Meta-owned platforms (i.e., Facebook, Instagram, and Messenger) and TikTok revealed that only about 7% disclosed loot box presence. The vast majority of social media advertising (93%) was therefore non-compliant with UK advertising regulations and also EU consumer protection law. In the UK alone, the 93 most viewed TikTok adverts failing to disclose loot box presence were watched 292,641,000 times total or approximately 11 impressions per active user. Many people have therefore been repeatedly exposed to prohibited and socially irresponsible advertising that failed to provide important and mandated information. Implementation deficiencies with ad repositories, which must comply with transparency obligations imposed by the EU Digital Services Act, are also highlighted, e.g., not disclosing the beneficiary. How data access empowered by law can and should be used by researchers is practically demonstrated. Policymakers should consider enabling more such opportunities for the public benefit.
On Bayes Factors for Hypothesis Tests
Authors: Klauer Karl Christoph , Meyer-Grant Constantin Gregor , Kellen David
Published: January 2024

We develop alternative families of Bayes factors for use in hypothesis tests as alternatives to the popular default Bayes factors. The alternative Bayes factors are derived for the statistical analyses most commonly used in psychological research – for one-sample and two-sample t tests, for regression and ANOVA analyses. They possess the same desirable theoretical and practical properties as the default Bayes factors and satisfy additional theoretical desiderata while mitigating against two features of the default priors that we consider implausible. They can be conveniently computed via an R package that we provide. Furthermore, hypothesis tests based on Bayes factors and those based on significance tests are juxtaposed. This discussion leads to the new finding that default Bayes factors as well as the alternative Bayes factors are equivalent to test-statistic based Bayes factors as proposed by Johnson (2005). We highlight test-statistic based Bayes factors as a general approach to Bayes-factor computation that is applicable to many hypothesis-testing problems for which an effect-size measure has been proposed and for which test power can be computed.
A role of rectangularity in perceiving a 3D shape of an object
Authors: Dvoeglazova Maria , Sawada Tadamasa
Published: January 2024

Rectangularity and perpendicularity of contours are important properties of 3D shape for thevisual system and the visual system can use them as a priori constraints for perceiving shape veridically.The present article provides a comprehensive review of prior studies of the perception of rectangularityand perpendicularity and it discusses their effects on 3D shape perception from both theoretical andempirical approaches. It has been shown that the visual system is biased to perceive a rectangular 3Dshape from a 2D image. We thought that this bias might be attributable to the likelihood of arectangular interpretation but this hypothesis is not supported by the results of our psychophysicalexperiment. Note that the perception of a rectangular shape cannot be explained solely on the basis ofgeometry. A rectangular shape is perceived from an image that is inconsistent with a rectangularinterpretation. To address this issue, we developed a computational model that can recover arectangular shape from an image of a parallelopiped. The model allows the recovered shape to beslightly inconsistent so that the recovered shape satisfies the a priori constraints of maximumcompactness and minimal surface area. This model captures some of the phenomena associatedwith the perception of the rectangular shape that were reported in prior studies. This finding suggeststhat rectangularity works for shape perception by incorporating it with some additional constraints.
Urban Street Network Design and Transport-Related Greenhouse Gas Emissions around the World
Authors: Boeing Geoff , Pilgram Clemens , Lu Yougeng
Published: January 2024

This study estimates the relationships between street network characteristics and transport-sector CO2 emissions across every urban area in the world and investigates whether they are the same across development levels and urban design paradigms. The prior literature has estimated relationships between street network design and transport emissions---including greenhouse gases implicated in climate change---primarily through case studies focusing on certain world regions or relatively small samples of cities, complicating generalizability and applicability for evidence-informed practice. Our worldwide study finds that straighter, more-connected, and less-overbuilt street networks are associated with lower transport emissions, all else equal. Importantly, these relationships vary across development levels and design paradigms---yet most prior literature reports findings from urban areas that are outliers by global standards. Planners need a better empirical base for evidence-informed practice in under-studied regions, particularly the rapidly urbanizing Global South.