bluuebunny/crossref_metadata_2025 huggingface dataset:
Phenolic compounds of cultivated chicory (Cichorium intybus L.)
Authors: Mavrina P. O. , Malankina E. L.
Published: June 2022

Common chicory (Cichorium intybus L.) is widely known in traditional medicine of many countries, but in official medicine its use is limited as a part of biologically active additives. Despite the available information about pharmacological activity of leaf extracts, their use as a medicinal herbal raw material is almost not considered. The purpose of the work is to study the accumulation dynamics of phenolic compounds (PC) in the leaves of cultivated chicory to optimize the time of harvesting the above-ground mass. The article presents data on the accumulation dynamics of PC in the leaves of two varieties of cultivated chicory, and also compares the obtained data with similars of wild-growing chicory.

Results. It was noted that the content of phenolic compounds in the leaves of cultivated chicory is 1,5-2 times higher in comparison with the raw materials of wild plants. The studied varieties differ in the content of PC by 8% in average. It has been established that the main phenolic compounds in the leaves of cultivated chicory are chicoric, chlorogenic and cafftaric acids; their total content in the obtained extracts is 55 %. It was noted that the period of maximum accumulation of PC in leaves falls on the end of september – beginning of october. The established chemical composition, a higher content of phenolic compounds compared to wild plants, as well as the coincidence of the maximum accumulation of PC in the leaves with the approximate date of harvesting chicory roots allows us to consider its cultivation in culture as a promising direction with the aim of the integrated use of the obtained raw materials for both food and pharmaceutical industry.
Photometric method of response to changes in potato varieties to nitrogen stress
Authors: Volkova E. N. , Sheloukhova N. A.
Published: June 2022

Relevance. The use of non-invasive photometric methods for assessing the stress states of plants makes it possible to assess the physiological state and resistance of plants.

Material and methods. In small-field and vegetation experiments, we studied the photometric indicators of the physiological response of potato varieties (reflection coefficients in different ranges) to nitrogen stress created by five doses of fertilizers using contact (N-tester) and remote (N-sensor) methods.

Results. Potato varieties released for the conditions of the North-Western region of the Russian Federation were studied for their ability to withstand stress provided by low and high levels of nitrogen nutrition of plants and different weights of planting tubers. The resistance of plants of different genotypes to external and internal stressors was studied by the reflection coefficients measured in 4 channels, which characterized the differences in the physiological state of plants. Ensuring the potential genotypic resistance of the organism in the form of a decrease in FIS F1,3 corresponds to the inclusion of various mechanisms of plant adaptation to external or internal influences, depending on the genotype. In the vegetative experiment, of the studied photo-optical reflection coefficients, the most informative were the FIS F1,3 indicators, which showed that the overall viability of such varieties as Peterburgsky, Charodey and Kholmogorsky turned out to be increased. The reaction type of the Kholmogorsky variety is the most promising for growing plants under stress conditions.
The effectiveness of the plant growth regulator Atonic Plus on potatoes in the conditions of the Moscow region
Authors: Vasilieva S. V. , Zeyruk V. N. , Derevyagina M. K. , Belov G. L. , Kolesova E. A.
Published: June 2022

The results of evaluating the effectiveness of the plant growth regulator Atonic Plus on potatoes as a stimulator of development, immunomodulator and protectant of the negative effects of pesticides in the crop protection system in the agro-climatic conditions of the Central region of the Russian Federation (Moscow region) are presented.In the extreme weather conditions of the growing season of 2010, the growth regulator Atonic Plus effectively demonstrated its qualities in the form of the formation of adaptability and anti-stress resistance in potato plants, providing an increase in yield relative to control by 1.8-7.1% and the quality of tubers is not only compared to the control, but also relative to the reference version. The combined use of a growth regulator with a fungicide contributed to an increase in the yield of standard potatoes in early and mid-late potato varieties by 2-2.5 times compared with the control.
Principles for optimizing the composition of a complex of machines for cleaning and restoring reclamation canals
Authors: Abdulmazhidov Kh. A.
Published: June 2022

The article is devoted to the principles of optimizing the composition of the complex of machines for cleaning the reclamation channels of the drainage network The fundamental initial documents in determining the composition of the complex of machines for the production of operational, repair and restoration works are technological maps for carrying out repair measures to restore the reclamation channels of the drainage system. Technological maps are formed taking into account the requirements for the elements of the drainage system, due to the specific conditions of the zone of economic regions, the natural and production characteristics of reclamation facilities.
Von "Original und Kopie" - Die Karte als historisches Dokument in der Vermittlung der Kartensammlung des Bundesamtes für Landestopografie swisstopo
Authors: Frei Philippe
Published: June 2022

Die Karte als historisches Dokument in der Vermittlung der Kartensammlung des Bundesamtes für Landestopografie swisstopo
contribution concrète des bibliothèques suisses à la lutte contre les problématiques écologiques
Authors: Baumberger Julie
Published: June 2022

La contribution concrète des bibliothèques suisses à la lutte contre les problématiques écologiques
Universitäre Weiterbildung und Digitalisierung in Zeiten der COVID-19-Pandemie
Authors: Rohr Christian
Published: June 2022

Ansprache anlässlich der Diplomfeier des 7. Studiengangs CAS/MAS ALIS 2018-2020
digitales Repositorium für graue Bernensia
Authors: Kähler Ursula
Published: June 2022

Umfeldanalyse und praktische Empfehlungen für digitale Publikationen in der Bernensia-Sammlung an der Universitätsbibliothek Bern
Erarbeitung eines Erschliessungs-, Konservierungs- und Digitalisierungskonzepts für das Negativarchiv von Marcel Bolomey
Authors: Fuhrer Lea
Published: June 2022

Erarbeitung eines Erschliessungs-, Konservierungs- und Digitalisierungskonzepts für das Negativarchiv von Marcel Bolomey
Bewertung fotografischer Bestände. Der Walter Heim-Nachlass im Archiv für Zeitgeschichte der ETH Zürich
Authors: Haffter Isabelle
Published: June 2022

Bewertung fotografischer Bestände. Der Walter Heim-Nachlass im Archiv für Zeitgeschichte der ETH Zürich
Ewolucja procesów suburbanizacji w regionie miejskim Łodzi
Authors: Jakóbczyk-Gryszkiewicz Jolanta
Published: June 2022

W niniejszej pracy procesy suburbanizacji rozpatrywane będą w kontekście przemian demograficznych, funkcjonalnych oraz przestrzennych w regionie miejskim Łodzi – w samym mieście i jego strefie podmiejskiej zarówno bliższej, jak i dalszej.
Mejoramiento de las propiedades mecánicas del concreto con ACR empleando aditivo nanosílice
Authors:   , Ayala Aguilar Kevin Josué , Ccallo Pérez Marie
Published: June 2022

En este artículo se analiza la influencia de un aditivo a base de nanosilice en el concreto elaborado con agregado a partir de concreto reciclado. Para lo cual, se ha realizado un programa de laboratorio donde se analizan las propiedades físicas de los materiales y las propiedades en estado fresco y endurecido del concreto a distintas edades. El objetivo principal del estudio es demostrar las mejoras cuantitativas de resistencia a compresión y tracción del concreto con ACR empleando nanosilice. Asimismo, el diseño óptimo para los casos propuestos es la mezcla M4 (100% ACR y 1% nanosilice) con el cual se logra mejorar en 21% respecto a la muestra M3 (100% ACR) a 28 días. Finalmente, el diseño M4 tiene una mayor resistencia a compresión comparado con la mezcla M0 (1) concreto convencional sin nanosilice. Por consiguiente, la utilización del concreto con ACR es factible en términos de resistencia.
Genesis of 5-pl Level Logistic Transport Systems in the Light of New Anti-Russian Sanctions
Authors: Pokrovskaya Oksana
Published: June 2022

Purpose: To conduct an analytical study of the genesis of 5-pl logistic providing format in Russia taking into account the new conditions of external sanctions. In particular, the attempt was made to give answers to the questions: “What extent to, the changes in global transport and logistics market will affect business transformation in Russia? Whichsoever will the logistic transport systems become? What does doing business new format represent? How logistic transport systems transform into business ecosystems? What are the prerequisites for 5-pl genesis in Russia?” Methods: Analytical review method for Russia transport-logistic market state in the conditions of new sanctions is applied. Results: The analysis of new conditions that can be considered as prerequisites for the creation of fundamentally new formats of interaction in supply chains — the genesis of 5-pl providing — allows us to define 5-pl providing as an innovative mechanism for the improvement of the positions of logistic transport systems in the domestic market which’s undergone radical changes. Practical importance: An analytical review of the prerequisites and factors-accelerators for the formation of 5-pl logistic providing and of digital ecosystems in the context of new sanctions opposite Russia has been carried out. It’s been established that the genesis of 5-pl services of MaaS format contributes to the development of a new market on “online-assembling” of logistic delivery schemes based on the principles of logistics, transparency, import substitution, multimodality, digitalization, multivariance, customer orientation, quality and complexity. Based on the results of the study, the potential appearance of logistic transport systems of 5-pl digital ecosystem format as of March 2022 has been formulated.
Application of Mortgage-Investment Analysis Method for the Assessment of Market Value of Land Plots Burdened With Outstanding Loans
Authors: Kolan'kov Sergey , Kaptelin Dmitriy
Published: June 2022

Purpose: To consider the matter on the necessity to apply mortgage-investment analysis method for to assess market value of lands burdened with outstanding loans. To show the possibility to write down calculation formulas both given and not-given changes in a net operating income and in an asset value of being estimated land; to offer calculation formula variants for mortgage-investment analysis traditional techniques. To give recommendations on the assessment of price-forming indicator series. To classify mortgage-investment analysis method at its application for land market value cost evaluation. Methods: Market comparisons; mortgage-investment analysis; capitalization of land rent; capitalization by calculation models of assumed usage, investment group, debt coverage coefficient. Akerson, Elwood, residue. Results: The need to improve the methodology parameters is indicated. It’s established which calculation formulas of the methodology require an actualization due to the changes occurred in a land rent since the moment of initial definition of the values of given quantities. To increase the calculation result reliability it’s necessary to account for a big variability of the land exploitation conditions. Practical importance: There is given a composition for the method of capitalization by calculating models. The possibility to write down calculating formulas both given and not given changes of net operating income and asset value of being estimated land is demonstrated. It is proposed application sphere expansion for land rent capitalization method. The methodologies can be recommended for a practical use.
Analysis of Investment Attractiveness of “Green” Shares of “RZHD” JSC
Authors: Sacuk Tat'yana , Lobodina Renata
Published: June 2022

Purpose: To consider principles of green financing, their application practice in Russian Federation. To show up directions of the activity of those companies which development will raise attractiveness of socially and ecologically responsible investment of a bankroll. To pursue the analysis of the investment program of energetic enterprises, comprising transport holding. Methods: Research has been pursued for global approaches in investment project evaluation, in particular, there has been considered and assessed the investment program of the enterprise comprising JSC “RZHD”. The analysis of an explanatory note has been made on the realization of investment programs, aimed to the update of fixed assets, on the example of Oktyabr’skaya Administration of Energy-Supply of — Transenergo structural subdivision — an affiliate of JSC “RZHD”. Results: The indexes of “green finances” of various countries are considered, verification criteria have been researched of projects and programs which support society social welfare and natural environment care policies, Regulations are characterized which adjust ESG (Environmental Social Governance)-financing in Russian Federation. Issue dynamics of “green” obligations of a railway sector enterprise is analyzed. The trends, which development of will raise the attractiveness of a socially and ecologically responsible payroll investment, are indicated. The information on organizations, occupied with being embodied programs of energy effectiveness, is given. The drawbacks in information, being presented for verifying the issuance of stocks which provide for the implementation of ESG-programs, are shown up. Practical importance: The research obtained results of the article can be applied in the sphere of evaluation of investment programs for energetic and transport industries on the matter of ESG-principles compliance.
Creation and Development of Engineering Entrepreneurship School: Industry University Experience
Authors: Panychev Aleksandr , Pokrovskaya Oksana , Drozdova Mariya
Published: June 2022

Purpose: To characterize model, concept and composition of engineering entrepreneurship school project, including consideration of matters of topicality and practical significancy of educational system transition from traditional to in principle new forms, integrated into modern university digital ecosystem with account for world trends in digitalization, for digital economy state strategy provisions, intellectual priorities of industrial branch development. Methods: The work uses materials of Internet open sources as well as uses the program of PSTU (Petersburg State Transport University) development till 2030. Ecosystem approaches as well as modular and project-based ones are applied to work organization of the engineering entrepreneurship school. The methods of innovation management, engineering entrepreneurship and system analysis are used. Results: The study reflects conceptual basics of the development and introduction of an innovative educational model — Engineering Entrepreneurship School (EES) — created by the team of the first engineering transport university of Russia — Emperor Alexander I St. Petersburg State Transport University. The results of realization first experience of EES work stages, including EES appearance and architecture characterization, are presented. Practical significance: The application and subsequent scaling of PSTU unique experience as an industry university will allow to implement outrunning training with expanded scarce competencies of a human capital and will form growth points for transport education competitive ability in modern Industry 4.0.
Pogled odozgo
Authors: Krstić Aleksandra
Published: June 2022

Veliki broj političara koristi vizuelni medijski sadržaj za potrebe lične promocije,‎ predizbornih kampanja i za komunikaciju sa biračima. Pored televizijskih ‎snimaka i fotografija u štampanim medijima, političari sve više koriste ‎vizuelno-centrične digitalne platforme, poput Instagrama, Jutjuba, Snepčeta‎i TikToka, kako bi doprli do šire javnosti i obezbedili veću podršku. Jedan ‎broj političara redovno koristi Instagram kao mrežu koja beleži ogroman ‎rast u odnosu na druge poznate društvene mreže. Instagram je svojom‎ vizuelnošću omogućio političku hiperindividualizaciju, pa se čini da su inače ‎distancirani predsednici, premijeri i drugi političari sve „običniji” i bliži‎ građanima. Jedan od njih je i predsednik Srbije Aleksandar Vučić, čiji je zvanični‎ Instagram profil @buducnostsrbijeav poslednjih godina postao važan ‎izvor informacija mejnstrim medijima u Srbiji, pa i Javnom medijskom servisu.‎ Imajući u vidu ovaj kontekst, u radu se istražuje kako se na Instagram ‎profilu predsednika Srbije vizuelno reprezentuju građani Srbije i kao objekat‎i kao izvor politike. Na osnovu kvantitativne i kvalitativne analize fotografija ‎i video snimaka objavljenih u toku 2019. i 2021. godine, identifikuju se glavni‎ vizuelni okviri u kojima se predstavljaju građani Srbije, kao i vizuelne strategije‎ na osnovu kojih Aleksandar Vučić stupa u interakciju sa običnim ljudima, uspostavlja odnose sa pojedinim društvenim i profesionalnim grupama, a istovremeno šalje određene političke poruke.‎‎‎‎‎‎
Pengaruh Metode Bermain Peran terhadap Hasil Belajar PKN di SD Donorojo
Authors: Irawati Devi , Mukodi Mukodi , Suryatin Suryatin
Published: June 2022

Penelitian ini bertujuan untuk mengetahui adakah pengaruh metode bermain peran terhadap hasil belajar  di SD kecamatan Donorojo pada mata pelajaran PKn materi bangga sebagai bangsa Indonesia. Jenis penelitian ini adalah Quasi Eksperimen. Penelitian ini dilakukan pada semester genap tahun pelajaran 2018. Subjek penelitian ini adalah SD yang dipilih secara random sampling. Pemgumpulan data menggunakan dokumentasi dan tes hasil belajar. Teknik analisis menggunakan bantuan Program SPSS for Windows 16. Hasil penelitian menunjukkan bahwa ada pengaruh signifikan pada hasil belajar siswa kelas eksperimen yang mendapatkan perlakuan khusus dengan metode bermain peran dibandingkan dengan kelas yang diberi perlakuan pembelajaran biasa menggunakan ceramah. Berdasarkan hasil rerata diperoleh kelas eksperimen memiliki rata-rata 88,33 yang berarti hasil rerata tersebut lebih tinggi daripada  kelas kontrol dengan rata-rata 83,00. Berdasarkan hasil uji-t pada kelas kontrol dan kelas eksperimen diperoleh nilai t sig0.023, nilai sig<0,05 (0.023<0,05). Hal ini menunjukkan bahwa ada pengaruh metode bermain peran terhadap hasil belajar PKn di SDN Kecamatan Donorojo tahun pelajaran 2018.
Kesulitan Belajar Dimasa Pandemi pada Mahasiswa Prodi Pendidikan Jasmani Kesehatan dan Rekreasi STKIP PGRI Pacitan.
Authors: Astuti Ridha Kurniasih
Published: June 2022

Penelitian ini bertujuan untuk mengetahui implementasi penerapan pembelajaran jarak jauh dan kesulitan model belajar jarak jauh yang sedang dialami mahasiswa khususnya pada mahasiswa Pendidikan Jasmani Kesehatan dan Rekreasi. Penelitian ini menggunakan jenis deskriptif kuantitatif. Penelitian ini didapatkan hasil bahwa 10 orang belajar jika ada tugas dari dosen dan 5 orang belajar mandiri meskipun tidak ada tugas dari dosen dan mencari bahan belajar sendiri untuk penguatan materi. Pada penggunaan media belajar di rumah sejumlah 9 orang menjawab bahwa mereka memiliki dan menggunakan secara maksimal media belajar yamh ada di rumah masing-masing, sedangkan 6 orang kurang memaksimalkan media belajar yang ada di rumah. Pada aspek lingkungan belajar sejumlah 2 orang menjawab bahwa lingkungan belajar dan orang sekitarnya kurang peduli terhadap proses belajarnya, 9 orang menjawab bahwa lingkungan belajar dan orang disekitarnya peduli dengan cara monitoring terhadap hal-hal pembelajaramn yang dilakukan anaknya, sedangkan sisanya 4 orang menjawab bahwa orang-orang disekitarnya turut serta membantu mencarikan solusi dan ikut terampil membantu dalam keikutsartaan anak dalam pembelajaran daring.
Preparing of Active Recombinant AEP free of Acid-activation.
Authors: Ma Muge , Tang Simon TM , Luk Louis YP
Published: June 2022

Asparaginyl endopeptidase is a useful biocatalyst for site-specific protein bioconjugation. However, existing recombinant protocol is lengthy requiring cap removal of the zymogenic enzymes through acid activation and extra chromatographic steps. Here, we describe an activation-free approach for AEP preparation where the cap and core domains are prepared as separate entities during gene expression. An AEP variant from Oldenlandia affinis (OaAEP1b-C247A) can be prepared without the need of acid treatment giving a yield of ~1.5-2.2 mg of enzyme per litre of culture. Likely because of a decrease in chromatography time and an increase of homogeneity, activity of the split AEP was found to be ~3-fold higher than those obtained using existing protocols, highlighting its potential usefulness.
Left axillary cannulation for acute type A aortic dissection
Authors: Sun Yangxue , Meng MaoLong , Li Gang , Guo HongWei
Published: June 2022

The most commonly used arterial cannulation sites for type A aortic dissection are right axillary artery, femoral artery and both. Direct central aortic cannulation has also been reported. In rare cases, it is extremely difficult to choose an arterial cannulation site for type A aortic dissection due to involvement of the right axillary and both femoral arteries. Herein, we present a 39-year-old male with acute type A aortic dissection with involvement of the right axillary and both femoral arteries. Left axillary cannulation was made and selective cerebral perfusion was performed through direct left common carotid artery cannulation during circulatory arrest. Surgery was performed to replace the ascending aorta and total arch combined with a frozen elephant trunk implantation. The patient recovered uneventfully. To our knowledge, this is a rare case of total aortic arch replacement with frozen elephant trunk implantation through left axillary arterial cannulation for type A aortic dissection in the literature. Left axillary cannulation is a safe and useful choice for type A aortic dissection surgery when right axillary and femoral cannulation are not safe and reliable.
Stents versus Bypass Surgery – 3-Year Mortality Risk of Patients with Coronary Interventions Aged 50+ in Germany
Authors: Nestler Sophia , Kreft Daniel , Donndorf Peter , Ince Hüseyin , Doblhammer Gabriele
Published: June 2022

ObjectivesDue to demographic aging, the prevalence of coronary artery disease (CAD) is expected to increase in the future, resulting in a growing demand for stent and bypass interventions. This study aims to investigate the mortality risk of patients following conventional coronary artery bypass grafting (CABG) or endovascular procedure by the implantation of bare-metal stents (BMS) or drug-eluting stents (DES).MethodsBased on a random sample of 250,000 members of Germany’s largest health insurance ‘Allgemeine Ortskrankenkassen’ (AOK) from 2004 to 2015, incident CAD patients were analyzed by Cox Proportional-Hazard models. Risk adjustment was made for sex, age, other cardiac diseases, non-cardiovascular comorbidities and years since intervention. Due to later admission of DES and thus a shorter observation time, mortality was examined for 3 years since the intervention. ResultsBMS represented the most frequent procedure (48%). We found similar proportions of CABG (19%) and DES interventions (23%). After risk adjustment, the models showed a 21% (p=0.004) lower mortality risk of patients with DES and also a 21% (p=0.002) lower mortality risk of CABG patients compared to persons with BMS.ConclusionBased on a large-scale dataset, our study demonstrated survival advantages of CABG and DES interventions over BMS, with no differences between the DES and CABG groups. The results help to assess the risks of coronary interventions. Aspects of quality of life, severity of postoperative physical limitations, duration of rehabilitation, patients’ preferences, and aspects of cost-effectiveness for hospitals and society should be further considered.
A comparative LCA of external wall assemblies in context of Iranian market: considering embodied and operational energy through BIM application
Authors: Jafari Milad , Khoshand Afshin , Sadeghi Naimeh , Mirzanagh Pantea Abdollahi
Published: June 2022

Building envelopes have a critical role in the construction sector's sustainability. The main aim of this research is to assess the environmental impacts of typical exterior wall assemblies and present the best option to the Iranian market, taking into account both embodied and operational energy. Autodesk Green Building studio is used to determine the operating loads of each wall. Simapro, a life cycle assessment software, is used to help manage data on environmental impacts. The results show that the most severe damage category for all of the analyzed walls is human health. Also, the environmental impact of the end-of-life stage is insignificant in comparison with the production and use stages. If reducing carbon emissions is a major priority, replacing one square meter of masonry brick wall (the worst option) with Prefabricated extruded polystyrene (XPS) drywall (the best option) could save 1257.85 kgCO2eq. The operational phase of the specified walls has a wide range of environmental impacts. Prefabricated Knauf drywall and prefabricated XPS drywall consume less energy for the operating phase since they use a sufficient quantity of isolations, leading to better total environmental performance. In conclusion, the thermal performance of building materials should be given more attention.
Prevalence of Systemic Lupus Erythematosus and coexisting autoimmune diseases in Puerto Rico in the context of Hurricane Maria and the COVID-19 pandemic
Authors: Gilman Casey K. , Rivera Evián Pérez , Rincones Alexandra , Chervony Melyorise Sepúlveda , Lee Johanna , Marquez Alan , Castilla Christian , Santiago Michelle , Cortes Ada
Published: June 2022

Background: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that tends to coexist with other autoimmune conditions. The prevalence and etiology of the concurrent autoimmune diseases of SLE patients remains unknown. In Puerto Rico (PR) the prevalence of SLE was last reported in 2007 as a striking 159 per 100,000 individuals. The purpose of this investigation is to provide an updated prevalence of SLE and its autoimmune comorbidities in Puerto Rico in the setting of Hurricane Maria and the COVID-19 pandemic. Methods: Patient record information from the Puerto Rico Health Insurance Administration (PRHIA) was used to identify individuals with SLE between the years 2018 through 2020. Demographic characteristics such as age and sex were recorded. In addition, medications and comorbidities were evaluated. Prevalence was estimated.Results: A total of 12,918 cases of SLE were analyzed. Prevalence was estimated to be 536 per 100,000 individuals at its peak in 2019. In individuals with SLE, 3.6% had at least 1 additional autoimmune diagnosis. Patients who were female, aged 35 to 54, or with a record of using corticosteroids within the past three years were identified as more likely to be affected by an additional autoimmune disease.Conclusions: Our findings reveal an increased prevalence of SLE as compared to previous studies in both the United States and Puerto Rico. We also contributed to limited literature on the co-occurence of SLE with other autoimmune diseases and its associated factors.
Treatment of Extramedullary Plasmacytoma of the Rectum with Endoscopic Mucosal Resection: A Case Report and Literature Review
Authors: Fan Ling , Fu Yan , Liu Yi , Huang Hua
Published: June 2022

Background Extramedullary plasmacytoma (EMP) is an unusual plasma cell disease.We report a case of EMP arising in the rectum, which is fully removed using endoscopic mucosal resection (EMR).Methods The patient’s clinical, endoscopic, and histologic data were reviewed, as well as the past literature of rectal EMP with a focus on the clinical presentation, treatment and outcome.Results A 64-year-old woman was referred to our hospital with recurrent diarrhea for longer than half a month. She underwent colonoscopy which revealed a polypoid lesion. The lesion was fully excised using EMR, and histopathological examination coupled with immunohistochemistry of the endoscopic biopsy confirmed a primary EMP of the rectum. She did not receive radiotherapy or chemotherapy after being diagnosed with EMP and experienced no recurrence or progression during the 6-month follow-up period.Conclusions Rectal EMP is an extremely rare clinical entity, Only 14 cases have been reported in the English-language literature as far as we know. Clinical suspicion is infrequent owing to its location and nonspecific manifestations. The diagnosis of EMP requires biopsy-proven monoclonal plasma cell infiltration of a single lesion, and the exclusion of multiple myeloma. Although EMP is a highly radiosensitive tumor, endoscopic therapy is increasingly becoming a good option for colorectal EMP when complete endoscopic resection of the tumor is possible. Although rectal EMP has an indolent course and favorable prognosis, long-term follow-up is recommended due to the possibility of relapse or progression to multiple myeloma.
Water, water everywhere and not a streamflow gauge in sight: Estimating freshwater inflows in an ungauged watershed at the Big Boggy National Wildlife Refuge, USA
Authors: Madewell Matthew J. , Feagin Rusty A. , Huff Thomas P. , Balboa Bill
Published: June 2022

Bays and estuaries often rely on freshwater inflows to maintain the salinity balance necessary to sustain their fisheries. Reduced freshwater inflows, particularly during summer seasons, can be detrimental to the health of these systems. Despite an extensive network of streamflow gauges in the U.S., many coastal watersheds remain ungauged. Our objective was to identify a way to quickly build a water budget for an ungauged watershed, using limited data, to determine its freshwater inflow contributions to an estuary. We developed and tested this method for Big Boggy Creek, which flows into East Matagorda Bay (EMB), Texas. Streamflow into and out of Big Boggy Creek was quantified at key upstream and downstream points. Over the study period, we found average monthly freshwater inflows of 1,897 megaliters (ML). Historic and predicted freshwater inflows over a longer time period were calculated using a data-driven model, based on our water budget. Historic monthly inflows for this model averaged 2,000 ML from 1953 to 2019 for Big Boggy Creek. Predicted inflows followed three climate scenarios outlined by the Intergovernmental Panel on Climate Change. Using these findings, we developed an inflow decision tool to assist resource managers in assessing future freshwater inflows into EMB. We show two inflow improvement actions for EMB that can be informed by using this tool—purchasing water from the local river authority and increasing the effective watershed. The approaches developed in this study can be applied to similarly ungauged watersheds to budget, model, and predict their freshwater inflow contributions to estuaries.
Privacy-preserving, Efficient, and Effective Machine Learning
Authors: Wu Chuhan , Wu Fangzhao , Qi Tao , Huang Yongfeng , Xie Xing
Published: June 2022

Privacy protection is critical for responsible artificial intelligence. Federated learning is a privacy-aware machine learning paradigm, which is often combined with differential privacy to guarantee privacy protection. Unfortunately, existing methods cannot achieve a satisfactory tradeoff between privacy and utility when the models are large, and their computation and communication costs are also huge. Here, we present a differentially private, efficient, and effective machine learning method named FedPrompt to learn big models in a federated way via prompt tuning. It only learns, perturbs, and exchanges the small prompt models injected into the big models. FedPrompt is validated on five datasets. The results show FedPrompt can achieve 0.5%~34.7% better performance than standard federated learning under same privacy budgets, meanwhile saving 99% of communication cost, 75% of memory, and 64% of training time. FedPrompt offers a new direction to efficiently and effectively distributed machine learning with privacy guarantees.
Butyrate Attenuated Lithium-Induced Cardiometabolic Disorders Through Enhanced PI3K/eNOS Independent of Adenosine Deaminase in Male Wistar Rats
Authors: Oyabambi Adewumi Oluwafemi , Bamidele Olubayode , Boluwatife Aindero Blessing
Published: June 2022

Background
Cardiometabolic disease is becoming a main cause of death worldwide with over ten million fatalities annually. Lithium (Li), a known therapy for bipolar disorders is now evolving as a major cause of various cardiometabolic disorders and sodium butyrate (NaB) which is a short chain fatty acid and gut microbiota has been identified to possess an amazing therapeutic effect against cardiometabolic disorders. As a result, the current study aims to evaluate sodium butyrate impact on lithium-induced cardiometabolic disorders.
Methods
Twenty male Wistar rats weighing between 125-130g were used for the experiment. They were grouped into Control and treated groups respectively as (CTR; normal chow), Lithium only (Li; 5mg/kg), Sodium butyrate only (NaB) (200mg/kg) and NaB + Lithium (Li; 5mg/kg + NaB; 200mg/kg) for six weeks, after a week of acclimatization; n = 5. The animals were euthanized with 0.2ml of ketamine hydrochloride, blood samples were collected and cardiac tissue homogenates were measured for plasma Fasting Blood Glucose (FBG), insulin, phosphatidylinositol 3 Kinase (PIK3), Nitric oxide (NO), Glucose-6-phosphate dehydrogenase (G6PDH), malonyladehyde (MDA), Catalase, Sodium Dismutase (SOD), NADPH, Glutathione Peroxidase (GPx), and Adenosine deaminase /xanthine oxidase /uric acid (ADA/XO/UA) using standard spectrophotometric method.
Results
The results showed that lithium significantly increased fasting blood sugar (FBS), GPx, catalase, SOD, and malonyladehyde (MDA) (P < 0.05) while causing a statistical reduction in plasma insulin, plasma and cardiac concentration of NADP+, G6PDH, PI3K, endothelial nitric oxide synthase (eNOS), and Nitric Oxide (NO) in comparison with the control. However, butyrate attenuated plasma GPx, catalase, SOD, MDA and significantly elevated plasma and cardiac PI3K, eNOS, NO, FBS, plasma insulin, plasma NADPH+ and G6PDH levels in relation to control. Also no change was observed in the plasma and cardiac ADA/XO/UA following sodium butyrate.
Conclusion
Therefore, butyrate has a remarkable therapeutic potential in lithium induced cardiometabolic disorders through vascular regeneration and glucometabolic control.
TIMP1, a promising target of tumor development diagnosis and treatment for colorectal cancer
Authors: Wen Hang , Chen Yan , Fu Zhenjie , Lv Hang , Chen Yitao , Lin Meiai
Published: June 2022

Background: Colorectal cancer is one of the most common malignancies globally, causing a tremendous social burden. Revealing causes and underlying molecular mechanisms and discovering molecular biomarkers for early diagnosis, prevention, and personalized treatment is critical.Methods: To identify the candidate genes in cancer progression, three microarray datasets were downloaded from the GEO database. GEO2R identified the differentially expressed genes (DEGs), and DAVID performed functional enrichment analyses. The protein-protein interaction network was constructed, and hub gene selection was performed using STRING. GEPIA2 was used to explore the expression level change of 10 hub genes and perform the prognosis corresponding information. RT-qPCR and immunoblotting were performed to verify the expression level of TIMP1 in clinical tissues. Results: A total of 223 DEGs were identified. The enrichment analysis results showed that the functions of the differentially expressed genes were mainly concentrated in ion transport, protein degradation, mineral absorption, and cancer processes. In the PPI network, ten genes were identified as hub genes. Compared with normal tissues, the rest of the genes were significantly overexpressed apart from CXCL12. Survival analysis showed that TIMP1 was significantly correlated with the poor prognosis of CRC patients. RT-qPCR and immunoblotting showed TIMP1 up-regulated considerably in CRC tissues. Conclusions: In conclusion, for colorectal cancer, combined with the functional characteristics and the current statistical analysis results, TIMP1 is a very promising target for diagnosis and treatment.
Mechanism of Erzhiwan in treating osteoporosis based on molecular docking technology and molecular dynamics simulation
Authors: Li Yanling , Li Ziliang , Ye Tongsheng , Hao Fuqi , Wang Yichi , Li Wenqian , Yan Qingfeng , Shi Huawei , Han Weijuan
Published: June 2022

This experiment was a network pharmacology research based on the theoretical system of traditional Chinese medicine. TCMSP database, PubChem database, RCSB database and SwissTargetPrediction database were used to study the effective chemical constituents of Ligustri lucidi Fructus and Ecliptae Herba in Erzhiwan, a traditional prescription for nourishing liver and kidney. Then using Genecards database, OMIM database, OMIM Gene Map and Metascape database to study the therapeutic targets of Osteoporosis. At last, using Cytoscape 3.6.0 software, its built-in Bisogenet and CytoNCA, AutoDockTools-1.5.6 software, PYMOL-2.2.0 software and Gromacs software, by drawing the relationship diagram between chemical components and disease targets, PPI network of disease, semi-flexible molecular docking technology, evaluation and analysis of enrichment pathway, molecular dynamics simulation, to study the therapeutic mechanism of Erzhiwan on osteoporosis. It is found that the intervention and regulation of Erzhiwan on osteoporosis were mainly realized through multiple targets of active ingredients and multiple pathways, which provided support for the continued development of Erzhiwan.
Same-Day Thyroidectomy Outcomes: A Canadian Multi-Center Retrospective Cohort Study
Authors: Fortin Mélyssa , Noik Maxine , Hudson Thomas J. , Silva Sabrina D. da , Forest Véronique-Isabelle , Hier Michael P. , Mlynarek Alex M. , Payne Richard J.
Published: June 2022

Background
The American Thyroid Association supports same-day thyroid surgery (SDT) in select patients. In practice, it is common for thyroid surgeons to monitor patients overnight for postoperative complications such as cervical hematoma, recurrent laryngeal nerve injury (RLN) and symptomatic hypocalcemia. We sought to determine the safety profile and predictive factors of adverse postoperative outcomes for SDT based on the experience of three large institutions.
Methods
A retrospective cohort study was conducted for all thyroidectomies performed at three McGill University tertiary and quaternary care centers in Montreal, Canada between January 1st, 2016 and November 13th, 2020. Patient characteristics were associated with outcomes by bivariate and multivariate analyses.
Results
A total of 2297 records were surveyed and 1983 patients (1513 females, 470 males) met the inclusion criteria. Amongst them, 603 (30.4%) patients were discharged the same day. The overall postoperative complication rate amongst SDT was 3.6% compared with 10.7% for inpatients (p < 0.0001). Cervical hematoma was not observed in the SDT group, whereas 8 inpatients (0.6%) developed this complication (p = 0.061). RLN injury occurred in 7 SDT (1.2%), compared with 35 (2.5%) inpatients (p = 0.050). Symptomatic hypocalcemia occurred in 3 SDT (0.5%) compared with 73 (5.3%) inpatients (p < 0.0001). 36 (6%) 30-day Emergency department (ED) visits were noted for SDT compared to 172 (12.5%) for inpatients (p < 0.0001), and none required readmission or reoperation within that postoperative period. In the multivariate logistic regression analysis, SDT patients were less associated with comorbidities and had a lesser risk to develop symptomatic hypocalcemia (p < 0.0001). SDT patients had lower 30-day ED (p = 0.041) and reoperation (p = 0.037) rates compared with the inpatient group.
Conclusion
This study demonstrates that SDT are safe in a select group of patients under the care of experienced thyroid surgeons at high volume thyroid surgery centers. SDT can also lead to significant cost savings in a publicly funded health care system. Further exploration is needed to clarify patient profiles most amenable to SDT and inform clinical decision-making.
Time and Error Analysis of Neural Network Model of Rectangular Vibrating Membrane
Authors: Pandey Vikas Kumar , Agarwal Himanshu , Aggarwal Amrish Kumar
Published: June 2022

Series solution of rectangular vibrating membrane (SSRVM) of the motion has been represented by Neural Network (NN) model. Experiments have been performed to find a combination of NN structure and size of sample data such that error and time cost of SSRVM are the minimum. Error and time cost of NN models have been studied w.r.t structure, size of sample, random choice of initial weights and selection of data. Peak signal to noise ratio (PSNR) between series solution and solution by NN model is approximately 50 dB. This ensures that solution obtained by NN model is acceptable at human visual system. The average training time of constructed NN models is better than state-of-the-art related to solution of differential equation by NN. NN models are 26 times faster than SSRVM for solution prediction.
OF Spine classification without CT Examination- does it work?
Authors: Spiegl Ulrich J. , Behr Lars , Osterhoff Georg , Rupprecht Gunnar , Scheyerer Max J. , Katscher Sebastian
Published: June 2022

Objectives: The purpose of this study was to investigate whether the addition of computed tomography (CT) to magnetic resonance imaging (MRI) improves the accuracy of classifying osteoporotic vertebral body fractures (OVBF). Methods: A retrospective analysis of a prospective single-center database has been performed. All consecutive patients who had suffered an acute thoracolumbar OVBF in one level II spine center between 2017 and 2019 were analyzed. All fractures were initially classified by 5 board-certified orthopaedic surgeons based on MRI and conventional radiographs. Afterwards a reclassification including CT scans were performed. Differences in OF classification and OF score values between both measurements were analyzed.Results: A total of 61 patients were analyzed with a mean age 75.8 years (SD: 8.8 years). In 82.9% of the cases, there was no difference in OF classification comparing classification based only on MRI versus MRI+CT. A difference of more than two OF types was observed in less than 1% of all ratings. The inter-rater reliabilities of the OF classification based on CT+MRI and MRI alone were 0.63 and 0.49, respectively. In 97.5% of the cases there was no therapy-relevant difference of the treatment recommendation with respect of a surgical or nonoperative treatment recommendation based on the OF score.Conclusion: In terms of the OF classification and the OF score, the addition of CT add limited value compared to conventional radiographs and MRI only. Additionally, there is only a minor rate of disagreement in treatment recommendations as by the OF score when adding a CT.
Secondary Hyperparathyroidism in Adult Chronic Hemodialysis Patients: Prevalence and Clinical Aspect
Authors: Bashir Ahmed Muhammad , Alici Gokhan , Wabari Mohamud Mire , Adani Abdulkamil Abdullahi
Published: June 2022

Background: Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD). Aim: The exact prevalence of secondary hyperparathyroidism in chronic hemodialysis patients in Somalia is unknown. In this study, we aimed to determine the prevalence of SHPT in chronic hemodialysis patients in Mogadishu, Somalia.Method: This retrospective analysis was carried out at the Mogadishu Somali Turkey Training and Research Hospital, Somalia’s largest dialysis center. All hemodialysis patients aged 18 years and older from the last year were included. The research excluded parathyroidectomy patients and patients on steroids, phenytoin, or phenobarbitone. This analysis covered 195 patients. Calcium, phosphate, albumin, vitamin D, urea, creatinine, and other electrolytes were tested.Results: The mean age of the 195 patients was 56.0±17.4, with 49.2% males and 50.88% females. End-stage kidney disease (ESKD) was caused by hypertension in 64.1% of the patients and diabetes in 30.8%. The mean hemodialysis time was 7.8±1.3 hours per week, and the mean duration was 39.6±15 months. The mean intact parathyroid hormone (iPTH) concentration was 458.59±636.96 pg/mL, phosphate was 4.24±2.15 mg/dL, corrected calcium was 8.70±0.97 mg/dL, and calcium phosphate product was 36.60±19.78 mg/dL. The mean vitamin D concentration was 33.53±19.70. We found that the prevalence of secondary hyperparathyroidism was 65.6%.Conclusion: We conclude that there is a high prevalence of secondary hyperparathyroidism in chronic hemodialysis patients in Somalia and that measures that predict vitamin D response, including sestamibi parathyroid scans and gland volume, should be studied further to prevent this high prevalence.
Structure design and experimental study on ultrasonic vibration-assisted induction brazing cubic boron nitride abrasive tools
Authors: Cai Kaida , Zhao Biao , Wu Bangfu , Ding Wenfeng , Zhao Yanjun , Zhu Jianhui , Si Wenyuan
Published: June 2022

Brazed abrasive tool has been widely used in high-precision machining of difficult-to-cut materials to improve the machining efficiency and quality. However, the severe wear and associated short service life during machining processes have to be faced for conventional induction brazed (CIB) abrasive tools owing to its weak bonding strength between abrasive grains and metal-bonded materials. In this case, a novel ultrasonic vibration-assisted induction brazing (UVAIB) device was developed to improve the abrasive bonding strength. Here, the frequency equation of the UVAIB device was derived using recursive methods, and then the geometric designation parameters were optimized with the finite element simulating method. In addition, the performance of UVAIB device was tested in terms of the impedance and amplitude. Subsequently, the comparative experiment trials were performed with the brazed abrasive tools under the CIB and UVAIB method. Results show that the ultrasonic energy loss of UVAIB device could be reduced, and then the amplification value and vibration uniformity could reach 8 and 92%, respectively. In addition, for CIB, there are a large number of pores and macro-cracks on the joints. However, the internal pores inside the metallic matrix of UVAIB were reduced, and only fewer and smaller micro-cracks could be found. Furthermore, the intergranular fracture of abrasive grains could be observed for CIB abrasive tools owing to the weak bonding interface caused by the existence of numerous micropores, whereas the grain transgranular fracture appeared once adopting the ultrasonic vibrating method.