bluuebunny/crossref_metadata_2025 huggingface dataset:
What is sex journalism or, rather, how does it become? Interviews with news workers on the risk and precarity of a gendered news niche
Authors: Middleweek Belinda
Published: September 2020

Numerous studies have found the reporting of sex is sensationalized and intended to create controversy while journalists have little regard for the topic. Such matters are important given the #MeToo movement has broadened public debate about sexual issues, practices and behaviors. However, there is scant research on the professional identities of journalists who specialize in sex news and the industrial, social and individual-level factors shaping their reportage. Extending an earlier qualitative study comprising interviews with female freelance journalists in North America, Canada, Germany and Australia, this article conceptualizes sex journalism as a specialism in flux and, using the concept of ‘biodigital vulnerability’, argues that sex journalists are exposed to gendered experiences of risk in their news work. The results suggest greater consideration for the professional and gendered identities of sex journalists may improve sex news coverage and optimize sexual health outcomes given the importance of sex news as a public information source.
Experiments in becoming: corporeality, attunement and doing research
Authors: Latham Alan , Wagner Lauren B
Published: September 2020

Human geography has become deeply interested in a range of research methods that focus on researchers’ corporeal engagement with their research sites. This interest has opened up an exciting set of research horizons, energising the discipline in a whole range of ways. Welcoming this engagement, this paper presents a series of meditations on the process of using the researcher’s corporeal learning as a research tool. Exploring two research projects, as well as the work of the photographer Nikki S Lee, it examines how the process of becoming corporeally capable might productively be framed as sets of ongoing experiments. Framing such engagements as experiments is a useful heuristic through which to think rigorously about what such research can claim as knowledge. More controversially, the paper argues that the heuristic of the experiment helps us to attend to the varying durations of becoming in ways that much existing work has discounted. Developing corporeal capacities – gaining a skill, becoming capable of doing a particular activity – involves becoming attuned to a range of thresholds, the crossing of which open up novel and frequently unexpected perspectives. Attunement to these thresholds does not arise simply through the process of mixing in and participating in a research site. It requires careful attention to the parameters of transformation involved in being able to participate. The paper explores how such parameters might be decided upon and calibrated as part of an ongoing engagement with a research site or event. Our aim is not to artificially restrict or constrain how human geographers approach their research design. Rather it is to encourage human geographers to show more courage in their use of corporeal based research methodologies.
Forging alternatively sacred spaces in Singapore’s integrated religious marketplace
Authors: Woods Orlando
Published: September 2020

This paper expands the notion of sacred space within the geographies of religion by arguing that spaces of religious praxis need to be understood in relation to the broader spatial logics within which they are embedded. Given that the spatial logics of urban environments tend to be secular and neoliberal in nature, it considers how religious groups respond to the realities of the marketplaces in which they operate by forging ‘alternatively sacred’ spaces. These spaces augment the appeal of religious groups in non-religious ways, thus making them more competitive players in a religious marketplace. Specifically, it explores how independent churches in Singapore create alternatively sacred spaces that are used for religious purposes, although their appeal and affective value do not accord with more traditional understandings of how sacred spaces should look, feel, or otherwise be engaged with. These spaces are designed to appeal to younger people, and to draw non-Christians to Christian spaces, and Christians to alternatively religious spaces. The extent to which they appeal to these groups provides insight into reimagination of religion under market conditions, spatial politics of value and ideological fissures between different Christian communities.
Influence of silicon dioxide addition and processing methods on structure, thermal stability and flame retardancy of EVA/NR blend nanocomposite foams
Authors: Walong Alif , Thongnuanchan Bencha , Sakai Tadamoto , Lopattananon Natinee
Published: September 2020

Rubber nanocomposite foams based on 60/40 ethylene vinyl acetate (EVA)/natural rubber (NR) were melt-mixed with flame retardant silicon dioxide (SiO2) (20 parts per hundred rubber, phr), and foamed by compression molding process. In this study, the effect of mixing phenomena of SiO2 through two different compounding techniques such as direct mixing (DM) and phase selective mixing (PSM) methods on structure, thermal stability, combustility and flame retardancy of EVA/NR blend nanocomposite foams were investigated. DM method is a melt mixing of EVA, NR, layered silicate and SiO2, followed by foaming. PSM is a new method based on pre-mixing EVA with SiO2, then melt mixing of EVA/SiO2 masterbatch with NR and layered silicate, and finally foaming. Based on TEM technique, it was found that the SiO2 was exclusively located in dispersed NR phase for the sample prepared by DM method, and the SiO2 was preferably dispersed in continuous EVA matrix when PSM method was employed. However, the different mixing methods did not significantly alter their cellular structures. The thermal stability and char residue content of foamed samples with SiO2 increased obviously when compared with those of corresponding foams without SiO2. The results based on limiting oxygen index (LOI) test and oxygen bomb calorimetry indicated that the foams combined with SiO2 had better combustion resistance and flame retardancy due to barrier effect of thermally stable silicon-based char layer. Further, the SiO2 filled foamed system obtained from the PSM method showed a higher degree of improvement in thermal stability, combustion resistance and flame retardancy than that of DM method because the homogeneous dispersion of SiO2 in EVA matrix rather than the selective dispersion in NR phase. This resulted in the continuity of flame retardant EVA/SiO2 phase in the 60/40 EVA/NR nanocomposite foams, which exerted more efficient fire barrier of the silicon-based char layer.
Adverse Childhood Experiences (ACEs), Alcohol Use in Adulthood, and Intimate Partner Violence (IPV) Perpetration by Black Men: A Systematic Review
Authors: Lee Kerry A. , Bright Charlotte Lyn , Betz Gail
Published: September 2020

Intimate partner violence (IPV) is a serious social and public health problem in the United States. Adverse childhood experiences (ACEs) and alcohol use have been found to be associated with IPV perpetration; however, limited studies have examined the interrelationships of these variables among Black men. This is the first known study to systematically review and synthesize studies on the interrelationships of ACEs, alcohol use, and IPV perpetration among Black men. Comprehensive literature searches were conducted in PubMed and six EBSCOhost databases by a research librarian and two researchers. Twenty studies met inclusion criteria: empirical; available in English; included ACEs, alcohol use/substance abuse, and IPV perpetration variables in the analyses; and samples included Black/African American male IPV perpetrators aged ≥ 18 years. ACEs were found to be associated with IPV perpetration among Black men, but findings were mixed regarding the role of alcohol in relation to ACEs and IPV. Numerous ACE factors (1–6) were used across studies. However, findings regarding the co-occurrence of ACE factors are inconclusive because none of the studies examined the cumulative effects of exposure to more than one type of ACE on subsequent IPV perpetration. Implications for policy, practice, and research related to the interrelationships of ACEs, alcohol use, and IPV perpetration are provided. Future work is needed to better explicate the interrelationships among these constructs.
Combining the Passeo-18 Lux Drug-Coated Balloon and the Pulsar-18 Bare Metal Stent: 12- and 24-Month Outcomes of the BIOLUX 4EVER Investigator-Initiated Trial
Authors: Deloose Koen , Bosiers Marc , Peeters Patrick , Verbist Jürgen , Maene Lieven , Beelen Roel , Keirse Koen , Hendriks Jeroen , Lauwers Patrick , Wauters Jeroen , Verschueren Merel
Published: September 2020

Purpose:

To report the outcomes after treating stenotic or occluded femoropopliteal lesions with a drug-coated balloon (DCB) followed by the implantation of a thin-strut self-expanding bare metal stent in the BIOLUX 4EVER trial ( ClinicalTrials.gov identifier NCT02211664).

Materials and Methods:

The prospective, multicenter, physician-initiated BIOLUX 4-EVER trial was conducted at 5 centers in Belgium and enrolled 120 patients (mean age 70.9±10.5 years; 79 men) with symptomatic stenotic or occluded de novo femoropopliteal lesions. A fifth of the patients had diabetes mellitus and nearly half had previous peripheral artery interventions. The lesions were a mean 83.3±49.5 mm long with a mean reference vessel diameter of 5.26±0.59 mm. Lesions were treated with a Passeo-18 Lux DCB followed by the implantation of a Pulsar-18 bare metal stent. Follow-up visits were conducted at 1, 6, 12, and 24 months postprocedure; the main outcome was primary patency at 12 months.

Results:

Technical success was obtained in all patients. Primary patency was observed in 89.9% of patients (95% CI 84.0% to 95.8%) at 12 months and in 83.5% at 24 months (95% CI 89.9% to 97.3%), and freedom from target lesion revascularization was 93.6% (95% CI 89.9% to 97.3%) and 86.1% (95% CI 79.9% to 92.3%), respectively. Ten patients died throughout the course of the trial (90.7% survival at 24 months), all of noncardiovascular causes. The ankle-brachial index improved from 0.68±0.09 at baseline to 0.93±0.11 and 0.93±0.12 at 12- and 24-month follow-up visits (p<0.001). An improvement of at least 1 Rutherford category was observed in 91 of 94 patients (96.8%) at 12 months and 78 of 83 patients (93.4%) at 24 months (p<0.001).

Conclusion:

The combination of a Passeo-18 Lux DCB followed by a Pulsar-18 stent implantation produced safe and effective outcomes in the treatment of femoropopliteal lesions at up to 24 months. Adding paclitaxel to the bare nitinol stent platform by predilating with a Passeo-18 Lux DCB seems to increase efficacy at 1 and 2 years compared with the use of bare metal stents only, which were investigated in the precursor 4-EVER study.
Blots on the Anthropocene: Micropolitical Interventions With Young People in a University Museum
Authors: Rousell David , Hohti Riikka , MacLure Maggie , Chalk Hannah-Lee
Published: September 2020

In this article, we discuss a series of artistic interventions in a university museum co-created by young people, researchers, and museum curators. We focus on the co-development of techniques for disrupting and re-imagining museological spaces and times, while exploring young people’s shifting sense of inheritance in relation to the “Anthropocene” as a particular figuration of the current epoch. Drawing together an eclectic range of sources at the intersections of schizoanalysis, posthumanism, decolonial studies, and surrealism, we argue that young people’s interventions in the museum constitute micropolitical nodes of resistance to the colonial-capitalistic capture of subjectivity that dominates the current epoch.
The Pupil Diameter as a Possible Indicator of Neurodegenerative Diseases and Response to Acetylcholinesterase Inhibitors Therapy: In-Depth Measurements Following Topical Administration of Tropicamide and Pilocarpine
Authors: Nuzzi Raffaele , Bojino Alessandro , Polito Maria Sole , Luppi Chiara , Tridico Federico , Massaia Massimiliano
Published: September 2020

Background:

The aim of this study is to assess whether pupillary modifications following ocular anticholinergic and cholinergic drugs can identify subjects with neurodegenerative diseases from early stages.

Methods:

51 subjects were divided into 3 groups, according to different neurodegenerative diseases, and compared with a control group of 10 patients. Pupil diameter has been measured at different times after topical administration of tropicamide 0.01% in the right eye. Then, topical administration of pilocarpine 0.06% has been performed, followed by pupillary constriction measurement. Pupillary response rates were stratified according to acetylcholinesterase inhibitors intake.

Results:

Observed mydriasis and pupillary constriction was similar in all study groups at all evaluation times. Patients without acetylcholinesterase inhibitors intake presented greater mydriasis.

Conclusions:

Although it was not possible to observe significant differences among groups in terms of pupillary response, the analysis of pupillary features may become an useful tool to detect efficacy of acetylcholinesterase inhibitors.
The Successful Treatment of an Ilio-Iliac Fistula and Aneurysms Affecting the Abdominal Aortic and Iliac Arteries via Endovascular Stent Graft Repair
Authors: Sueyoshi Eijun , Iwano Yusuke , Oka Taiga , Nishimura Takamasa , Honda Takahide , Kawaguchi Yutaro , Koike Hirofumi , Nagayama Hiroki , Sakamoto Ichiro , Uetani Masataka
Published: September 2020

Spontaneous ilio-iliac arteriovenous fistula (AVF) associated with aneurysms affecting the abdominal aortic and iliac arteries is a rare condition. The classical clinical symptoms of ilio-iliac AVF include high-output heart failure, abdominal pain, abdominal bruits and thrills, a pulsatile abdominal mass, and venous congestion symptoms (leg edema and hematuria). The prompt repair of AVF is necessary to restore the patient’s hemodynamics.

 We report a case in which a patient with aneurysms affecting the abdominal aortic and iliac arteries and an ilio-iliac AVF presented with high-output heart failure and leg ischemia and was successfully treated via endovascular stent graft repair.
Aortoduodenal Fistula After Endovascular Aortic Repair for an Inflammatory Abdominal Aortic Aneurysm: A Case Report
Authors: Moriyama Hideki , Kimura Keiichi , Takago Shintaro , Nishida Yoji , Shimada Mari , Takemura Hirofumi
Published: September 2020

Aortoenteric fistula after endovascular aortic repair for an abdominal aortic aneurysm is a rare but severe complication. Particularly, a case of inflammatory abdominal aortic aneurysm is extremely rare and there are only 3 reported cases. A 70-year-old man underwent endovascular aortic repair for impending rupture of an inflammatory abdominal aortic aneurysm and was medicated steroids for approximately 2 years. Four years after endovascular aortic repair, he developed endograft infection with an aortoduodenal fistula and a left psoas abscess. He underwent total endograft excision, debridement, in situ reconstruction of the aorta using prosthetic grafts with omental coverage, and digestive tract reconstruction to prevent leakage. Pseudomonas aeruginosa was detected in the infected aortic sac. The patient has not experienced recurrence of infection in the 35 months since his operation.
“I’m Not a Number, I’m a Human Being:” A Phenomenological Study of Women’s Responses to Labeling
Authors: Boppre Breanna , Reed Shon M.
Published: September 2020

Since the 1970s, the number of women under correctional supervision has risen drastically. With the increase in women’s system-involvement, it is important to consider the impact that crime-focused labels may have on women’s self-perceptions and reentry. This study applies a feminist lens to labeling theory. Through phenomenological interviews and focus groups with 19 women under community supervision in a Northwestern State, women’s responses were analyzed using thematic analysis. Four major themes emerged highlighting the distinct contexts of women’s responses to labels and the impacts of such labels on their lives. Theoretical and policy implications are discussed.
Campus Free Speech in Polarised Times
Authors: Ben-Porath Sigal
Published: September 2020

Tensions around open expression at universities in the United States and around the world arise mainly from two sources. Campus members increasingly call to restrict hurtful and hate-based speech, and demand silencing, ‘cancelling’ or ‘de-platforming’ outside speakers and campus members who espouse extreme ideological views. At the same time, public and political actors from outside the university attempt to undermine its independence by demanding greater voice to conservative speakers, in an effort to rebalance the ideological makeup of the university. Inclusive freedom – an approach that focuses on ways to promote both open expression and an inclusive climate in contemporary universities – is presented as a theoretical and a practical response to these tensions. Inclusive freedom is anchored in the university’s core mission, bounded by its educational and research goals, and reflects a practical commitment to allowing everyone to participate in an open exchange, which starts from all participants recognising their equal standing and dignity.
Doxycycline treatment of high-risk COVID-19-positive patients with comorbid pulmonary disease
Authors: Yates Paul A. , Newman Steven A. , Oshry Lauren J. , Glassman Robert H. , Leone Ashton M. , Reichel Elias
Published: September 2020

Infection with novel SARS-CoV-2 carries significant morbidity and mortality in patients with pulmonary compromise, such as lung cancer, autoimmune disease, and pneumonia. For early stages of mild to moderate disease, care is entirely supportive.

Antiviral drugs such as remdesivir may be of some benefit but are reserved for severe cases given limited availability and potential toxicity. Repurposing of safer, established medications that may have antiviral activity is a possible approach for treatment of earlier-stage disease. Tetracycline and its derivatives (e.g. doxycycline and minocycline) are nontraditional antibiotics with a well-established safety profile, potential efficacy against viral pathogens such as dengue fever and chikungunya, and may regulate pathways important in initial infection, replication, and systemic response to SARS-CoV-2. We present a series of four high-risk, symptomatic, COVID-19+ patients, with known pulmonary disease, treated with doxycycline with subsequent rapid clinical improvement. No safety issues were noted with use of doxycycline.

Doxycycline is an attractive candidate as a repurposed drug in the treatment of COVID-19 infection, with an established safety profile, strong preclinical rationale, and compelling initial clinical experience described here.

The reviews of this paper are available via the supplemental material section.
Identification of Cytotoxic Constituents from the Whole Plant of Isodon ternifolius
Authors: Pham Minh Quan , Le Thi-Thuy-Huong , Do Tien-Lam , Pham Thi-Hong-Minh , Pham Quoc-Long , Nguyen Phi-Hung , To Dao-Cuong
Published: September 2020

A new oxygenated spiroketone, isodonspiroketone (1), and 4 known ones (2-5) were isolated from the whole plant of Isodon ternifolius (D.Don) Kudô. The structure of isodonspiroketone (1) was determined by nuclear magnetic resonance, mass spectroscopy, and circular dichroism spectral data. Compound 3 has not been previously isolated from I. ternifolius. Their cytotoxic activities were evaluated against A549, HepG2, and MDA-MB-231 cancer cell lines in vitro. New compound (isodonspiroketone, 1) showed moderate cytotoxic activities against A549, HepG2, and MDA-MB-231 cancer cell lines with half-maximal inhibitory concentration values of 23.84 ± 2.73, 27.77 ± 3.01, and 17.26 ± 1.61 μM, respectively; meanwhile, the others were inactive.
Illicit Drugs and Reversible Cerebral Vasoconstriction Syndrome
Authors: Short Katherine , Emsley Hedley C. A.
Published: September 2020

Reversible cerebral vasoconstriction syndrome (RCVS) is a condition characterized by thunderclap headache and associated vasospasm of the cerebral vasculature. A multitude of factors are considered to potentially predispose to the development of RCVS. These potential precipitants include numerous illicit drugs. In this study, we investigated the role of illicit drugs as a precipitating factor for RCVS, through systematic review of the relevant literature. We found the strongest evidence for cannabis, but a relative lack of evidence to support other illicit drugs, particularly as individual precipitating factors. We also identified a lack of the consistent application of diagnostic criteria for RCVS, which undoubtedly hampers advancement of knowledge in this field. Consistent adherence to diagnostic criteria will be important for future studies. Ultimately, a prospective registry of RCVS cases would be advantageous to advance understanding of the condition and its underlying causes.
Injection-moulding of nitrogen-foamed bio-based microcellular poly(butylene succinate): Processing conditions/foam structure/flexural properties relationship
Authors: Ykhlef Nazim , Lafranche Eric
Published: September 2020

This paper aims to identify the main processing parameters that optimize as well the microcellular structure (cell size, cell density) of nitrogen (N2) foamed injection-moulded poly(butylene succinate) (PBS) as the resultant flexural properties of the part. The part beam geometry was designed so as to reproduce some geometrical shapes (e.g. thickness change, ribs, bosses or holes) occurring on most of industrial parts. A Taguchi L9 design of experiments (DOE) has been first used to quantify the effects of processing conditions on microcellular structure and mechanical performances. Among the processing parameters, the melt temperature, gas content, injection volumetric flow rate and back pressure were chosen for the DOE due to their level of influence on gas dissolution and nucleation phases. An analysis of variance (ANOVA) showed that the microcellular structure depended mainly on nitrogen content and, to a lesser extent, on back pressure representation of gas pressure saturation in the PBS/N2 system during the feeding stage. The resultant specific flexural properties were controlled by the skin/core ratio as well as the finesse of foam structure (cell sizes, cell density) but a 15% loss in specific performances was noted compared with the unfoamed part. The microcellular structure/mechanical performances could be thus established from the microstructure analysis. In a second step, the foamed microcellular structure has been improved by introduction of micro-talc in the PBS acting as cell nucleating agent (heterogeneous nucleation). A significant increase in cell density and cell reduction (40%) were observed.
Outcome of antidepressant drug discontinuation with taperingstrips after 1–5 years
Authors: Groot Peter C. , van Os Jim
Published: September 2020

Background:

Stopping antidepressants is often difficult due to withdrawal. Taperingstrips were developed to facilitate antidepressant discontinuation according to the recently described Horowitz-Taylor method, allowing for personalised titration of discontinuation to the intensity of withdrawal. A taperingstrip consists of antidepressant or other medication, packaged in a 28-day roll of small daily pouches, each with the same or slightly lower dose than the one before it. We previously reported that the short-term success rate of antidepressant taperingstrips was 71%. Here, we examine longer-term outcome after 1–5 years.

Methods:

Patients whose doctor had ordered taperingstrips between January 2015 and December 2019 were sent a questionnaire for participation in anonymised research in January 2020. Of 1012, 483 participated, of whom 408 (85%) had attempted antidepressant tapering.

Results:

Of the 408 patients included, 192 (47%) had used strips for tapering venlafaxine, 142 (35%) for paroxetine and 74 (18%) for other antidepressants. Median length of antidepressant use was 4 years, and most (61%) had tried to come off without taperingstrips at least once. After 1–5 years, 270 patients (66%) remained off antidepressants after tapering their antidepressant, 6 (2%) had successfully reduced their medication, 87 (21%) had restarted due to (self-reported) relapse, 35 had restarted for another indication (9%), and 10 (3%) reported another outcome. People with more severe experience of withdrawal prior to tapering, and people who had been on antidepressants for a shorter period of time, were more likely to remain off medication after 1–5 years.

Conclusion:

The previously reported 71% short-term success rate of taperingstrips in the most severely affected group, was matched by a 68% rate after 1–5 years. The evidence-based approach of personal tapering to counter withdrawal, as used for drugs causing withdrawal, for example, benzodiazepines, may represent a simple solution for an important antidepressant-related public health problem, without extra costs.
Law and medical practice: A comparative vignette survey of cardiologists in Norway and Denmark
Authors: Bjorvatn Afsaneh , Magnussen Anne-Mette , Wallander Lisa
Published: September 2020

Objective:

This article explores the implications of legal regulation for medical discretion and decision-making in Norway and Denmark.

Methods:

The article is based on a cross-national cross-sectional survey exploring cardiologists’ assessments of patient eligibility for specialist health care. Forty-two cardiologists in Norway and 48 in Denmark were presented with two standardized case vignettes in the form of patient referrals and were asked to assess whether the patient was eligible for treatment by a specialist, and if so, what waiting time would be assigned to the patient.

Results:

Primarily based on descriptive statistics, our findings indicate interesting similarities and variations. While there was only minor variation across the countries in cardiologists’ professional assessments about a patient with a more severe condition, judgements of eligibility for specialist treatment varied for a patient with a less severe medical condition. Moreover, Danish cardiologists distinguished between the more severe and less severe conditions to a much lesser extent when assessing eligibility for specialist treatment. For waiting times, there was considerable variation at the general level, from 1 week to 6 months. The assigned waiting times were on average double those for Norwegian cardiologists compared with their Danish counterparts. Denmark’s legal standardization of waiting times appears to lead to shorter waiting times than those prescribed by Norway’s legal regulations.

Conclusion:

For a single clear overall intention with a new policy, simpler legal regulations may be more effective than very detailed and specific requirements. If policymakers’ overall intention is for medical doctors to make complex decisions involving the prioritization of patients, then more individualized regulations seem to be a better tool.
Validation of 9-Grid Scheme for Localizing Osteochondral Lesions of the Talus
Authors: Martin Kevin D. , McBride Trevor J. , Horan Dylan P. , Haleem Amgad , Huh Jeannie , Groth Adam , Dawson Laura K.
Published: September 2020

Background:

A 9-grid scheme has been integrated into the foot and ankle literature to help clinicians and researchers localize osteochondral lesions of the talus (OLTs). We hypothesized that fellowship-trained orthopedic foot and ankle surgeons would have a high rate of intra/inter-observer reliability when localizing OLTs, therefore validating the scheme.

Methods:

We queried our institution’s foot and ankle radiographic database for magnetic resonance images with OLTs. Each MRI was reviewed by the senior author, and 2 key images (widest OLT diameter) from each tangential view were copied and combined onto one slide. Fifty consecutive deidentified images of ankles were then sent to 4 practicing fellowship-trained foot and ankle surgeons. Each was asked to identify which zone the OLT was localized within. A radiologist’s report served as the control. Statistical analyses were performed using Cohen and Fleiss kappa tests.

Results:

The reviewers demonstrated majority consensus on 45/50 images with substantial agreement for zones 4 and 6. The interobserver reliability was moderate with a κ = 0.55. The mean intraobserver reliability was substantial, with a κ = 0.79. A musculoskeletal radiologist determined there were 3 lesions in zone 7, 18 lesions in zone 4, and 29 lesions in zone 6.

Conclusion:

This study is the first to critically evaluate the 9-grid scheme and its reliability among orthopedic foot and ankle surgeons. Our study found that the 9-grid scheme is an accurate method of localization for OLTs with high intra- and moderate interobserver reliability between surgeons.

Level of Evidence:

Level IV, retrospective diagnostic study.
Recent developments in advanced diagnostic bronchoscopy
Authors: Chandrika Sharad , Yarmus Lonny
Published: September 2020

The field of bronchoscopy is advancing rapidly. Minimally invasive diagnostic approaches are replacing more aggressive surgical ones for the diagnosis and staging of lung cancer. Evolving diagnostic modalities allow early detection and serve as an adjunct to early treatment, ideally influencing patient outcomes. In this review, we will elaborate on recent bronchoscopic developments as well as some promising investigational tools and approaches in development. We aim to offer a concise overview of the significant advances in the field of advanced bronchoscopy and to put them into clinical context. We will also address potential complications and current diagnostic challenges associated with sampling central and peripheral lung lesions.
Clinical application of sodium-glucose cotransporter 2 inhibitor into a real-world setting of heart failure care
Authors: Tanaka Atsushi , Node Koichi
Published: September 2020

For years there have been concerns whether the results of large-scale clinical trials that include limited specific patient populations can be applied to patients in real-world clinical practice. Therefore, it is crucially important to verify whether emerging evidences obtained from large-scale clinical trials on limited specific patient populations can be applied to patients at real-world clinical settings. Recent cardiovascular outcome trials with sodium-glucose cotransporter 2 (SGLT2) inhibitors showed a consistent risk reduction of approximately 30% for hospitalization for heart failure (HF), and the SGLT2 inhibitors had a great potential to be effective for prevention of HF in a wide variety of type 2 diabetes (T2D) patients independent of their history of HF or cardiovascular disease (CVD). Furthermore, the DAPA-HF trial also demonstrated that dapagliflozin proved clinically effective in patients with HF with reduced ejection fraction regardless of diabetes, suggesting its robust benefits in some specific patients with HF. According to these evidences, SGLT2 inhibitor is increasingly recognized as an emerging and promising option to reduce the risk of HF in patient with T2D. To use appropriately SGLT2 inhibitors for HF prevention in the real-world setting, it would be required to determine the optimal patient population who can receive better clinical benefits from SGLT2 inhibitors. In this commentary, based on the current understandings and lessons learned from the most recent studies, we discussed the importance of future research on the safety and efficacy of SGLT2 inhibitor in clinical situations of HF other than those examined in previous cardiovascular outcome trials.
SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic
Authors: Rabaan Ali A. , Al-Ahmed Shamsah H. , Sah Ranjit , Tiwari Ruchi , Yatoo Mohd. Iqbal , Patel Shailesh Kumar , Pathak Mamta , Malik Yashpal Singh , Dhama Kuldeep , Singh Karam Pal , Bonilla-Aldana D. Katterine , Haque Shafiul , Martinez-Pulgarin Dayron F. , Rodriguez-Morales Alfonso J. , Leblebicioglu Hakan
Published: September 2020

A novel coronavirus (SARS-CoV-2), causing an emerging coronavirus disease (COVID-19), first detected in Wuhan City, Hubei Province, China, which has taken a catastrophic turn with high toll rates in China and subsequently spreading across the globe. The rapid spread of this virus to more than 210 countries while affecting more than 25 million people and causing more than 843,000 human deaths, it has resulted in a pandemic situation in the world. The SARS-CoV-2 virus belongs to the genus Betacoronavirus, like MERS-CoV and SARS-CoV, all of which originated in bats. It is highly contagious, causing symptoms like fever, dyspnea, asthenia and pneumonia, thrombocytopenia, and the severely infected patients succumb to the disease. Coronaviruses (CoVs) among all known RNA viruses have the largest genomes ranging from 26 to 32 kb in length. Extensive research has been conducted to understand the molecular basis of the SARS-CoV-2 infection and evolution, develop effective therapeutics, antiviral drugs, and vaccines, and to design rapid and confirmatory viral diagnostics as well as adopt appropriate prevention and control strategies. To date, August 30, 2020, no effective, proven therapeutic antibodies or specific drugs, and vaccines have turned up. In this review article, we describe the underlying molecular organization and phylogenetic analysis of the coronaviruses, including the SARS-CoV-2, and recent advances in diagnosis and vaccine development in brief and focusing mainly on developing potential therapeutic options that can be explored to manage this pandemic virus infection, which would help in valid countering of COVID-19.
Detecting multiple spatial disease clusters: information criterion and scan statistic approach
Authors: Takahashi Kunihiko , Shimadzu Hideyasu
Published: September 2020

Background

Detecting the geographical tendency for the presence of a disease or incident is, particularly at an early stage, a key challenge for preventing severe consequences. Given recent rapid advancements in information technologies, it is required a comprehensive framework that enables simultaneous detection of multiple spatial clusters, whether disease cases are randomly scattered or clustered around specific epicenters on a larger scale. We develop a new methodology that detects multiple spatial disease clusters and evaluates its performance compared to existing other methods.

Methods

A novel framework for spatial multiple-cluster detection is developed. The framework directly stands on the integrated bases of scan statistics and generalized linear models, adopting a new information criterion that selects the appropriate number of disease clusters. We evaluated the proposed approach using a real dataset, the hospital admission for chronic obstructive pulmonary disease (COPD) in England, and simulated data, whether the approach tends to select the correct number of clusters.

Results

A case study and simulation studies conducted both confirmed that the proposed method performed better compared to conventional cluster detection procedures, in terms of higher sensitivity.

Conclusions

We proposed a new statistical framework that simultaneously detects and evaluates multiple disease clusters in a large study space, with high detection power compared to conventional approaches.
Analysis of long-term outcomes in 44 patients following pelvic exenteration due to cervical cancer
Authors: Lewandowska Agnieszka , Szubert Sebastian , Koper Krzysztof , Koper Agnieszka , Cwynar Grzegorz , Wicherek Lukasz
Published: September 2020

Background

Pelvic exenteration (PE) may be associated with prolonged overall survival (OS) in selected patients with advanced or recurrent cervical cancer. However, the factors related to improved survival following PE are not clearly defined. The aim of this study was to perform a retrospective analysis of OS rates in a group of patients undergoing PE in order to identify the factors related to improved long-term outcomes.

Methods

Our study group consisted of 44 patients, including 21 squamous cell cancer (SCC) patients, 22 patients with adenocarcinomas (AC) of the cervix, and one patient with undifferentiated cervical carcinoma. The patients were categorized according to the type of surgery, namely, primary surgery (12 patients) or surgery due to cancer recurrence (32 patients).

Results

In the group of patients with recurrent cervical cancer, we found that improved OS correlated with the SCC histological type and the presence of vaginal fistula. The need for reoperation within 30 days and the presence of severe adverse events significantly worsened the prognosis. We found a non significant trend toward improved survival in those patients with tumor-free margins. Lymph node metastases, the initial stage of the disease, the time to recurrence, and a history of hysterectomy had no impact on patients’ OS. In the group of patients undergoing primary PE, we observed a trend toward improved survival among those diagnosed with vaginal fistula.

Conclusions

Pelvic exenteration seemed to improve the long-term outcomes for patients with SCC cancer recurrence and vaginal fistula whose surgery was unrelated to severe adverse events.
Economic linkage between urban development and livelihood of peri-urban farming communities in Ethiopia (policies and practices)
Authors: Mohammed Idris , Kosa Abdella , Juhar Nuredin
Published: September 2020

As urban expands into peripheral areas, peri-urban indigenous farmers lose their land and highly vulnerable to negative externalities of urbanization. The aim of the study is to assess the economic linkage between urban development and the livelihood of peri-urban farming communities, focus on current practice and policies. From Ethiopia, Amara regional state was selected. Through multistage sampling, five municipalities (Debra Birhan, Shewa Robit, Kombolcha, Dessie, and Woldia) were taken as the sample from Amara regional state. Interviews were conducted with 30 municipalities’ officials of the selected town. Questionnaires collected from 200 respondents of peri-urban evicted farmers. As the findings of the study suggest, peri-urban farmers’ evictions from their indigenous land for land re-development are the continuous process that negatively affects the livelihood of farming communities. The factors that contribute for urban expansion in Amara regional state are economic policy reform, the creation of enabling the environment for private investors, the unsatisfied demand of urban dwellers for residential, and expansion of public sector projects. A collaborative effect of policy limitations, potential conflicts, unplanned livelihood, and poor saving habits of peri-urban farmers, lack of municipality intervention and lack of good governance negatively affect the livelihood of peri-urban farmers and jeopardize the image of government. The forwarded solutions are municipalities should have fully implemented urban policies, should have work on mutual benefits of concerned stakeholders, farmers’ background should be recorded and continuous follow up of evicted farmers livelihood should be practiced.
Potential cuckoo hosts have similar egg rejection rates to parasitized host species
Authors: Yi Tingting , Sun Yue-Hua , Liang Wei
Published: September 2020

Background

Thrush species are rarely parasitized by cuckoos, but many have a strong egg recognition ability. To date, there is a limited understanding of the relationship between host egg rejection and cuckoo parasitism rate.

Methods

By using egg experiments in the field, we compared egg rejection between two non-parasitized potential host species and two parasitized hosts of cuckoos in the same region.

Results

The White-bellied Redstart (Luscinia phoenicuroides), a host of the Common Cuckoo (Cuculus canorus), rejected 66.6% of blue model eggs; the Elliot’s Laughingthrush (Trochalopteron elliotii), a host of the Large Hawk Cuckoo (Hierococcyx sparverioides), rejected 25% of blue model eggs and 46.1% of white model eggs; and the Chestnut Thrush (Turdus rubrocanus) and the Chinese Thrush (T. mupinensis), in which cuckoo parasitism has not been recorded, rejected 41.1 and 83.3% of blue model eggs, respectively. There were no significant differences in the egg rejection among them, although the Chinese Thrush showed the highest rate of egg rejection.

Conclusions

This study indicates that the egg recognition ability of cuckoo hosts has no correlation with the actual parasitism rate of cuckoos. We suggest that the egg recognition ability of the two potential host species may have been retained from a parasitic history with the cuckoo, while the two common host species have developed their egg rejection abilities due to current parasitism pressure. In addition, our study highlights the importance of the multi-cuckoo parasite system for better understanding the selection pressure of parasitism on the evolution of host egg recognition abilities.
Correction to: Promising anitidiabetic potential of Cuscuta reflexa leaves methanol extract in alloxaninduced diabetic rats
Authors: Mostofa Ronia , Begum Rayhana , Wang Hongbin , Begum Mst. Marium , Karim Rubaba , Begum Taslima , Siddiquee Nur Alam , Sultana Rebeka , Sultana Sonia , Kabir A. K. Lutful , Alam Sumaiya , Nova Tasnova Tasnim
Published: September 2020

An amendment to this paper has been published and can be accessed via the original article.
Triterpene saponins from Barringtonia acutangula (L.) Gaertn as a potent inhibitor of 11β-HSD1 for type 2 diabetes mellitus, obesity, and metabolic syndrome
Authors: Patil Vishal Shivalingappa , Khatib Nayeem A.
Published: September 2020

Background

Barringtonia acutangula (L.) Gaertn, Garcinia indica (Thouars) Choisy, and Feronia limonia (L.) Swingle is widely utilized in traditional folk medicine against diabetes, obesity, and metabolic syndrome but lacks the evidence of compound-protein interaction for the treatment.

Methods

Phytocompounds were retrieved from herbs databases and public repositories. Probable protein targets were predicted using BindingDB (p ≥ 0.7). The pathways modulated by compounds were analyzed using the STRING and KEGG pathways. The compound-protein-pathway network was constructed using Cytoscape v3.6.1. Druglikeness was predicted by Molsoft. Docking was performed by AutoDock vina by PyRx 0.8v.

Results

Among three plants, eleven triterpene saponins from B. acutangula showed druggable characteristics and identified to inhibit the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1/HSD11B1) as a key protein target and also inhibit/modulate other 27 protein molecules involved in the 3 major pathways i.e. Metabolic syndrome, cGMP-PKG signaling, and insulin resistance pathways and also these compounds showed interactions with the active site amino acid residues of 11β-HSD1. Among eleven compounds Barringtogenol B scored the highest binding affinity by forming a hydrogen bond with Ile218 active site residue of 11β-HSD1.

Conclusion

Triterpene saponins contained in B. acutangula bark and seed inhibits 11Β-HSD1 and this multi-compound contained enriched fraction could be the potent treatment regimen for T2DM, obesity, and MetS.
Local IGF Bioactivity Associates with High PAPP-A Activity in the Pericardial Cavity of Cardiovascular Disease Patients
Authors: Hjortebjerg Rikke , Rasmussen Lars Melholt , Gude Mette Faurholdt , Irmukhamedov Akhmadjon , Riber Lars P , Frystyk Jan , De Mey Jo G R
Published: September 2020

Objective

Pregnancy-associated plasma protein-A (PAPP-A) has been suggested as a proatherogenic enzyme by its ability to locally increase insulin-like growth factor (IGF) activity through proteolytic cleavage of IGF binding protein-4 (IGFBP-4). Recently, stanniocalcin-2 (STC2) was discovered as an inhibitor of PAPP-A. This study aimed to investigate IGFBP-4, PAPP-A, and STC2 as local regulators of IGF bioactivity in the cardiac microenvironment by comparing levels in the pericardial fluid with those in the circulation of patients with cardiovascular disease.

Methods

Plasma and pericardial fluid were obtained from 39 patients undergoing elective cardiothoracic surgery, hereof 15 patients with type 2 diabetes. Concentrations of IGF-I, intact and fragmented IGFBP-4, PAPP-A, and STC2 were determined by immunoassays and IGF bioactivity by a cell-based assay.

Results

In pericardial fluid, the concentrations of total IGF-I, intact IGFBP-4, and STC2 were 72 ± 10%, 91 ± 5%, and 40 ± 24% lower than in plasma, while PAPP-A was 15 times more concentrated. The levels of the 2 IGFBP-4 fragments generated by PAPP-A and reflecting PAPP-A activity were elevated by more than 25%. IGF bioactivity was 62 ± 81% higher in the pericardial fluid than plasma. Moreover, pericardial fluid levels of both IGFBP-4 fragments correlated with the concentration of PAPP-A and with the bioactivity of IGF. All protein levels were similar in pericardial fluid from nondiabetic and diabetic subjects.

Conclusions

PAPP-A increases IGF bioactivity by cleavage of IGFBP-4 in the pericardial cavity of cardiovascular disease patients. This study provides evidence for a distinct local activity of the IGF system, which may promote cardiac dysfunction and coronary atherosclerosis.
CDK4/6 Dependence of Cyclin D1–Driven Parathyroid Neoplasia in Transgenic Mice
Authors: Costa-Guda Jessica , Corrado Kristin , Bellizzi Justin , Romano Robert , Saria Elizabeth , Saucier Kirsten , Rose Madison , Shah Samip , Alander Cynthia , Mallya Sanjay , Arnold Andrew
Published: September 2020

The protein product of the cyclin D1 oncogene functions by activating partner cyclin-dependent kinases (cdk)4 or cdk6 to phosphorylate, thereby inactivating, the retinoblastoma protein pRB. Nonclassical, cdk-independent, functions of cyclin D1 have been described but their role in cyclin D1-driven neoplasia, with attendant implications for recently approved cdk4/6 chemotherapeutic inhibitors, requires further examination. We investigated whether cyclin D1’s role in parathyroid tumorigenesis in vivo is effected primarily through kinase-dependent or kinase-independent mechanisms. Using a mouse model of cyclin D1–driven parathyroid tumorigenesis (PTH-D1), we generated new transgenic lines harboring a mutant cyclin D1 (KE) that is unable to activate its partner kinases. While this kinase-dead KE mutant effectively drove mammary tumorigenesis in an analogous model, parathyroid-overexpressed cyclin D1 KE mice did not develop the characteristic biochemical hyperparathyroidism or parathyroid hypercellularity of PTH-D1 mice. These results strongly suggest that in parathyroid cells, cyclin D1 drives tumorigenesis predominantly through cdk-dependent mechanisms, in marked contrast with the cdk-independence of cyclin D1–driven mouse mammary cancer. These findings highlight crucial tissue-specific mechanistic differences in cyclin D1–driven tumorigenesis, suggest that parathyroid/endocrine cells may be more tumorigenically vulnerable to acquired genetic perturbations in cdk-mediated proliferative control than other tissues, and carry important considerations for therapeutic intervention.
Placement of a Supraglottic Airway to Overcome Airway Obstruction When Performing Nasal Fiberoptic Intubation in Infants With Pierre Robin Sequence: A Case Series
Authors: Phillips Mitchell , Jagannathan Narasimhan
Published: September 2020

Patients with Pierre Robin sequence present with numerous anatomical abnormalities that make mask ventilation and tracheal intubation challenging. In this case series, we describe a unique way to overcome upper airway obstruction with the placement of a supraglottic airway in 4 children with Pierre Robin sequence followed by flexible bronchoscopic nasotracheal intubation. This new approach is proven to be a successful method to overcome severe upper airway obstruction, provide continuous oxygenation, and allows nasotracheal intubation for intraoral procedures.