bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis
Authors: Zhang Yu-Xin , Yang Lu-Ping , Gai Cong , Cheng Cui-Cui , Guo Zhen-yu , Sun Hong-Mei , Hu Die
Published: August 2022

Background

Psychiatric disorders have seriously affected human life, one of the risk genes related to psychosis is the methylenetetrahydrofolatereductase (MTHFR) gene. This gene has a potential role in psychiatric disorders. Therefore, a meta-analysis is conducted to investigate the correlations between two prevalent MTHFR single nucleotide polymorphisms (SNPs), MTHFR C677T, A1298C, severe psychological disorders (schizophrenia, major depression, bipolar disorder).

Methods

A total of 81 published studies were screened and selected by a search of electronic databases up to April 2022. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between MTHFR polymorphism and psychiatric disorders susceptibility by using random effect models.

Results

We found that MTHFR C677T polymorphism is significantly related to schizophrenia and major depression in the overall population. MTHFR C677T has been linked to an increased risk of bipolar disorder in the recessive model (TT vs. CT + CC). Ethnic subgroup analysis shows that schizophrenia and major depression significantly correlate with MTHFR C677T and A1298C in Asian populations but not Caucasians. Besides, schizophrenia is correlated substantially with MTHFR C677T in the African population. However, the MTHFR A1298C polymorphism is only marginally linked to major depression.

Conclusion

Findings of the current study revealed that MTHFR may contribute to the common pathogenesis of psychiatric diseases and that its variants may be essential in controlling the expression of psychosis-related genes. This study could help the researchers and health specialists in the early diagnosis and treatment of psychiatric disorders.
Associations of α-linolenic acid dietary intake with very short sleep duration in adults
Authors: Liu Qianning , Shan Qingsong
Published: August 2022

Objectives

This study aimed to investigate the association of α-linolenic acid (ALA; 18:3 ω-3) dietary intake with very short sleep duration (<5 h) in adults based on the CDC's National Health and Nutrition Examination Survey data.

Methods

Multinomial logistic regression was used to explore the association of ALA intake with very short sleep. To make the estimation more robust, bootstrap methods of 1,000 replications were performed. Rolling window method was used to investigate the trend of the odds ratios of very short sleep with age. A Kruskal–Wallis test was applied to estimate the differences in the ORs of very short sleep between genders and different age groups.

Results

Compared with the first tertile, the ORs of very short sleep and the corresponding 95% CIs for the second and the third tertile of dietary ALA intake in males were 0.618 (0.612, 0.624) and 0.544 (0.538, 0.551), respectively, and in females were 0.575 (0.612, 0.624) and 0.432 (0.427, 0.437). In most cases, the differences between different ages were more significant than those between different sexes. Men's very short sleep odds ratios for the second tertile of ALA intake increased linearly with age before 60.

Conclusions

The risk of a very short sleep duration was negatively related to the dietary intake of ALA. The effect of ALA on very short sleep is significantly different among groups of different genders and ages.
Bringing the local back in. The role of territories in the “biological” transition process toward circular economy: A perspective of analysis
Authors: Taddeo Raffaella
Published: August 2022

As widely evidenced in the past decades, the level of “humanity's metabolism” is unsustainable and must be reduced. It is especially related to issues, such as availability of resources, impacts of transportation, waste management, and external costs that could adversely affect the economic and environmental scenario at a global level. In the transition to circular economy (CE), moving from the insights of industrial ecology (IE) and the related “biological paradigm”, it has been suggested that the meso scale is the one in which great efficiencies can be achieved; the focus is on territories in which networks of economic actors' express significant potential in terms of synergistic and efficient use of resources and wastes. This perspective article aims to propose a detailed methodological viewpoint of this issue, moving from the scientific and empirical experience gained in a long-term research project conducted by the author on the themes of IE, CE, and their development in local contexts. The first phase of the research was characterized by theoretical-methodological in-depth analysis, case studies, and pilot tests, including different operating local contexts to evaluate their potential for the development of IE-based approaches. The results obtained and the experiences gained in the first phase have been used to develop an interpretative framework for assessing the role of external factors in influencing the process of development. Currently, the research is aimed at developing an analytical model capable of representing both the structural and operational characteristics of such contexts and the relative factors of influence in view of the adoption of circular strategies for the territory in which they are located.
Emodin from Aloe inhibits Swine acute diarrhea syndrome coronavirus in cell culture
Authors: Zheng Shumei , Wang Xiaowei , Hu Huiqiong , Xia Yongbo , Diao Xiaoyuan , Qiu Wenjing , Xue Chunyi , Cao Yongchang , Xu Zhichao
Published: August 2022

Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging swine enteropathogenic coronavirus that causes severe diarrhea in neonatal piglets, leading to serious economic losses to the pig industries. At present, there are no effective control measures for SADS, making an urgent need to exploit effective antiviral therapies. Here, we confirmed that Aloe extract (Ae) can strongly inhibit SADS-CoV in Vero and IPI-FX cells in vitro. Furthermore, we detected that Emodin from Ae had anti-SADS-CoV activity in cells but did not impair SADS-CoV infectivity directly. The time-of-addition assay showed that Emodin inhibits SADS-CoV infection at the whole stages of the viral replication cycle. Notably, we found that Emodin can significantly reduce virus particles attaching to the cell surface and induce TLR3 (p < 0.001), IFN-λ3 (p < 0.01), and ISG15 (p < 0.01) expressions in IPI-FX cells, indicating that the anti-SADS-CoV activity of Emodin might be due to blocking viral attachment and the activation of TLR3-IFN-λ3-ISG15 signaling axis. These results suggest that Emodin has the potential value for the development of anti-SADS-CoV drugs.
Defending against FakeBob Adversarial Attacks in Speaker Verification Systems with Noise-Adding
Authors: Chen Zesheng , Chang Li-Chi , Chen Chao , Wang Guoping , Bi Zhuming
Published: August 2022

Speaker verification systems use human voices as an important biometric to identify legitimate users, thus adding a security layer to voice-controlled Internet-of-things smart homes against illegal access. Recent studies have demonstrated that speaker verification systems are vulnerable to adversarial attacks such as FakeBob. The goal of this work is to design and implement a simple and light-weight defense system that is effective against FakeBob. We specifically study two opposite pre-processing operations on input audios in speak verification systems: denoising that attempts to remove or reduce perturbations and noise-adding that adds small noise to an input audio. Through experiments, we demonstrate that both methods are able to weaken the ability of FakeBob attacks significantly, with noise-adding achieving even better performance than denoising. Specifically, with denoising, the targeted attack success rate of FakeBob attacks can be reduced from 100% to 56.05% in GMM speaker verification systems, and from 95% to only 38.63% in i-vector speaker verification systems, respectively. With noise adding, those numbers can be further lowered down to 5.20% and 0.50%, respectively. As a proactive measure, we study several possible adaptive FakeBob attacks against the noise-adding method. Experiment results demonstrate that noise-adding can still provide a considerable level of protection against these countermeasures.
The Role of CT in the Staging and Follow-Up of Testicular Tumors: Baseline, Recurrence and Pitfalls
Authors: Pierre Thibaut , Selhane Fatine , Zareski Elise , Garcia Camilo , Fizazi Karim , Loriot Yohann , Patrikidou Anna , Naoun Natacha , Bernard-Tessier Alice , Baumert Hervé , Lebacle Cédric , Blanchard Pierre , Rocher Laurence , Balleyguier Corinne
Published: August 2022

Ultrasound imaging of the testis represents the standard-of-care initial imaging for the diagnosis of TGCT, whereas computed tomography (CT) plays an integral role in the initial accurate disease staging (organ-confined, regional lymph nodes, or sites of distant metastases), in monitoring the response to therapy in patients who initially present with non-confined disease, in planning surgical approaches for residual masses, in conducting follow-up surveillance and in determining the extent of recurrence in patients who relapse after treatment completion. CT imaging has also an important place in diagnosing complications of treatments. The aims of this article are to review these different roles of CT in primary TGCT and focus on different pitfalls that radiologists need to be aware of.
OATD-02 Validates the Benefits of Pharmacological Inhibition of Arginase 1 and 2 in Cancer
Authors: Grzybowski Marcin Mikołaj , Stańczak Paulina Seweryna , Pomper Paulina , Błaszczyk Roman , Borek Bartłomiej , Gzik Anna , Nowicka Julita , Jędrzejczak Karol , Brzezińska Joanna , Rejczak Tomasz , Güner-Chalimoniuk Nazan Cemre , Kikulska Agnieszka , Mlącki Michał , Pęczkowicz-Szyszka Jolanta , Olczak Jacek , Gołębiowski Adam , Dzwonek Karolina , Dobrzański Paweł , Zasłona Zbigniew
Published: August 2022

Background: Arginases play essential roles in metabolic pathways, determining the fitness of both immune and tumour cells. Along with the previously validated role of ARG1 in cancer, the particular significance of ARG2 as a therapeutic target has emerged as its levels correlate with malignant phenotype and poor prognosis. These observations unveil arginases, and specifically ARG2, as well-validated and promising therapeutic targets. OATD-02, a new boronic acid derivative, is the only dual inhibitor, which can address the benefits of pharmacological inhibition of arginase 1 and 2 in cancer. Methods: The inhibitory activity of OATD-02 was determined using recombinant ARG1 and ARG2, as well as in a cellular system using primary hepatocytes and macrophages. In vivo antitumor activity was determined in syngeneic models of colorectal and kidney carcinomas (CT26 and Renca, respectively), as well as in an ARG2-dependent xenograft model of leukaemia (K562). Results: OATD-02 was shown to be a potent dual (ARG1/ARG2) arginase inhibitor with a cellular activity necessary for targeting ARG2. Compared to a reference inhibitor with predominant extracellular activity towards ARG1, we have shown improved and statistically significant antitumor efficacy in the CT26 model and an immunomodulatory effect reflected by Treg inhibition in the Renca model. Importantly, OATD-02 had a superior activity when combined with other immunotherapeutics. Finally, OATD-02 effectively inhibited the proliferation of human K562 leukemic cells both in vitro and in vivo. Conclusions: OATD-02 is a potent small-molecule arginase inhibitor with optimal drug-like properties, including PK/PD profile. Excellent activity against intracellular ARG2 significantly distinguishes OATD-02 from other arginase inhibitors. OATD-02 represents a very promising drug candidate for the combined treatment of tumours, and is the only pharmacological tool that can effectively address the benefits of ARG1/ARG2 inhibition. OATD-02 will enter clinical trials in cancer patients in 2022.
Advances in Transversal Topics Applicable to the Care of Bladder Cancer Patients in the Real-World Setting
Authors: Garrido Siles Marga , López-Beltran Antonio , Pelechano Paula , García Vicente Ana María , Gironés Sarrió Regina , González-Haba Peña Eva , Rodríguez Antolín Alfredo , Zapatero Almudena , Arranz José Ángel , Climent Miguel Ángel
Published: August 2022

Recommendations regarding transversal topics applicable to bladder cancer patients independent of tumor grade and stage were established by members of the Spanish Oncology Genitourinary Multidisciplinary Working Group (SOGUG). Liquid biopsy in urine and blood samples is useful in the surveillance of non-muscle-invasive and muscle-invasive bladder cancer, respectively. Multiparametric MRI is an accurate, faster and non-invasive staging method overcoming the understaging risk of other procedures. The combination of FDG-PET/MRI could improve diagnostic reliability, but definite criteria for imaging interpretation are still unclear. Hospital oncology pharmacists as members of tumor committees improve the safety of drug use. Additionally, safety recommendations during BCG preparation should be strictly followed. The initial evaluation of patients with bladder cancer should include a multidimensional geriatric assessment. Orthotopic neobladder reconstruction should be offered to motivated patients with full information of self-care requirements. Bladder-sparing protocols, including chemoradiation therapy and immune checkpoints inhibitors (ICIs), should be implemented in centers with well-coordinated multidisciplinary teams and offered to selected patients. The optimal strategy of treatment with ICIs should be defined from the initial diagnostic phase with indications based on scientific evidence. Centralized protocols combined with the experience of professional groups are needed for the integral care of bladder cancer patients.
Temporal Heterogeneity of HER2 Expression and Spatial Heterogeneity of 18F-FDG Uptake Predicts Treatment Outcome of Pyrotinib in Patients with HER2-Positive Metastatic Breast Cancer
Authors: Gong Chengcheng , Liu Cheng , Tao Zhonghua , Zhang Jian , Wang Leiping , Cao Jun , Zhao Yannan , Xie Yizhao , Hu Xichun , Yang Zhongyi , Wang Biyun
Published: August 2022

Background: This study aimed to evaluate tumor heterogeneity of metastatic breast cancer (MBC) and investigate its impact on the efficacy of pyrotinib in patients with HER2-positive MBC. Methods: MBC patients who underwent 18F-FDG PET/CT before pyrotinib treatment were included. Temporal and spatial tumor heterogeneity was evaluated by the discordance between primary and metastatic immunohistochemistry (IHC) results and baseline 18F-FDG uptake heterogeneity (intertumoral and intratumoral heterogeneity indexes: HI-inter and HI-intra), respectively. Progression-free survival (PFS) was estimated by the Kaplan–Meier method and compared by a log-rank test. Results: A total of 572 patients were screened and 51 patients were included. In 36 patients with matched IHC results, 25% of them had HER2 status conversion. Patients with homogenous HER2 positivity had the longest PFS, followed by patients with gained HER2 positivity, while patients with HER2 negative conversion could not benefit from pyrotinib (16.8 vs. 13.7 vs. 3.6 months, p < 0.0001). In terms of spatial heterogeneity, patients with high HI-intra and HI-inter had significantly worse PFS compared to those with low heterogeneity (10.6 vs. 25.3 months, p = 0.023; 11.2 vs. 25.3 months, p = 0.040). Conclusions: Temporal heterogeneity of HER2 status and spatial heterogeneity of 18F-FDG uptake could predict the treatment outcome of pyrotinib in patients with HER2-positive MBC, which provide practically applicable methods to assess tumor heterogeneity and guidance for treatment decisions.
Effects of DSM-5 Betel-Quid-Related Symptoms, Pathological Behaviors, and Use Disorder on Oral Squamous Cell Carcinoma Risk
Authors: Wang Wen-Chen , Chiu Yueh-Tzu , Wang Yen-Yun , Lu Shuai-Lun , Chan Leong-Perng , Lee Chun-Ying , Yang Frances M. , Yuan Shyng-Shiou F. , Lee Chien-Hung
Published: August 2022

The neuroactive alkaloids in betel quid (BQ) can induce BQ addiction. We conducted a case–control study to investigate the effects of BQ-associated DSM-5 symptoms, pathological behaviors, and BQ use disorder (BUD) on oral squamous cell carcinoma (OSCC) risk. A total of 233 patients with newly diagnosed and histopathologically confirmed OSCC and 301 sex- and age-matched controls were included. BQ-related DSM-5 symptoms in the 12 months prior to disease onset were used to measure psychiatric characteristics and BUD. Compared with nonchewers, chewers with the symptoms of unsuccessful cutdown of BQ consumption, neglecting major roles, social or interpersonal problems, abandoning or limiting activities, hazardous use, and continued use despite the awareness of the dangers had a 54.8-, 49.3-, 49.9-, 40.4-, 86.2-, and 42.9-fold higher risk of developing OSCC, respectively. Mild-to-moderate and severe BUD were, respectively, associated with a 8.2–8.5- and 42.3-fold higher OSCC risk, compared with BQ nonuse. Risky BQ use of pathological behavior was associated with a 12.5-fold higher OSCC risk in chewers with no BUD or mild BUD and a 65.0-fold higher risk in chewers with moderate-to-severe BUD (p for risk heterogeneity between the two BUD groups, 0.041). In conclusion, BQ-associated DSM-5 symptoms, pathological behaviors, and BUD severity are associated with the impact of BQ chewing on OSCC development. The pathological behavior of risky BQ use enhances OSCC risk in chewers with moderate-to-severe BUD. Preventing BUD in new BQ users and treating BUD in chewers who already have the disorder are two priorities in areas where BQ chewing is prevalent.
Local Consolidative Therapy for Oligometastatic Non-Small Cell Lung Cancer
Authors: Santos Patricia Mae G. , Li Xingzhe , Gomez Daniel R.
Published: August 2022

In the last 20 years, significant strides have been made in our understanding of the biological mechanisms driving disease pathogenesis in metastatic non-small cell lung cancer (NSCLC). Notably, the development and application of predictive biomarkers as well as refined treatment regimens in the form of chemoimmunotherapy and novel targeted agents have led to substantial improvements in survival. Parallel to these remarkable advancements in modern systemic therapy has been a growing recognition of “oligometastatic disease” as a distinct clinical entity—defined by the presence of a controlled primary tumor and ≤5 sites of metastatic disease amenable to local consolidative therapy (LAT), with surgery or stereotactic ablative body radiotherapy (SABR). To date, three randomized studies have provided clinical evidence supporting the use of LAT/SABR in the treatment of oligometastatic NSCLC. In this review, we summarize clinical evidence from these landmark studies and highlight ongoing trials evaluating the use of LAT/SABR in a variety of clinical contexts along the oligometastatic disease spectrum. We discuss important implications and caveats of the available data, including considerations surrounding patient selection and application in routine clinical practice. We conclude by offering potential avenues for further investigation in the oligometastatic disease space.
Patients with Metachronous Peritoneal Metastatic Mucinous Colorectal Adenocarcinoma Benefit More from Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) than Their Synchronous Counterparts
Authors: Herold Zoltan , Acs Miklos , Szasz Attila Marcell , Olasz Katalin , Hussong Jana , Mayr Max , Dank Magdolna , Piso Pompiliu
Published: August 2022

Background: Mucinous adenocarcinoma is a frequent subtype in colorectal cancer (CRC). A higher initial T-stage, poorer differentiation, worse response to anti-tumor therapies, and shorter survival are characteristic of mucinous CRC. Moreover, the therapeutic benefit of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) in mucinous CRC has not been significantly investigated. Methods: A retrospective analysis of 218 CRC patients with synchronous or metachronous peritoneal metastases was conducted. Results: 129 and 89 patients had synchronous and metachronous metastases, and 36 (27.8%) and 22 (24.8%) of these were mucinous CRC, respectively. Mucinous CRC was more frequent in the proximal colon, with a higher T-stage and N-stage and with an average peritoneal carcinomatosis index that was 2 values higher. Disease-specific survival was significantly worse in the synchronous mucinous group (median survival: 22.4 months vs. 36.3 months, p = 0.0229). In contrast, no such difference was observed in the metachronous cohort (32.6 months vs. 34.4 months, p = 0.6490). Conclusions: In the case of synchronous peritoneal metastases originating from mucinous CRC, the positive effect of CRS+HIPEC cannot be verified, and the added value of this highly invasive treatment is therefore somewhat questioned. However, CRS + HIPEC is recommended for metachronous metastases, since no difference between the two CRC-subtypes could be verified.
Pleiotropic Roles of Atrial Natriuretic Peptide in Anti-Inflammation and Anti-Cancer Activity
Authors: Fu Huafeng , Zhang Jian , Cai Qinbo , He Yulong , Yang Dongjie
Published: August 2022

The atrial natriuretic peptide (ANP), a cardiovascular hormone, plays a pivotal role in the homeostatic control of blood pressure, electrolytes, and water balance and is approved to treat congestive heart failure. In addition, there is a growing realization that ANPs might be related to immune response and tumor growth. The anti-inflammatory and immune-modulatory effects of ANPs in the tissue microenvironment are mediated through autocrine or paracrine mechanisms, which further suppress tumorigenesis. In cancers, ANPs show anti-proliferative effects through several molecular pathways. Furthermore, ANPs attenuate the side effects of cancer therapy. Therefore, ANPs act on several hallmarks of cancer, such as inflammation, angiogenesis, sustained tumor growth, and metastasis. In this review, we summarized the contributions of ANPs in diverse aspects of the immune system and the molecular mechanisms underlying the anti-cancer effects of ANPs.
Study of Radiation Damage Processes Caused by Hydrogen Embrittlement in Lithium Ceramics under High-Temperature Irradiation
Authors: Shlimas Dmitriy I. , Kozlovskiy Artem L. , Zdorovets Maxim V. , Khametova Ainagul A.
Published: August 2022

The aim of this work is to study the hydrogenation processes in lithium-containing ceramics under high-temperature irradiation. Irradiation was carried out with protons with an energy of 1 MeV and fluences of 1015–1017 ion/cm2 at irradiation temperatures of 300–1000 K. The choice of irradiation conditions is due to the possibility of simulation of the radiation damage accumulation processes in the near-surface layer of Li2TiO3 ceramics, as well as establishing the dependences of changes in structural parameters during temperature heating of samples during irradiation. It has been established that at irradiation fluences of 1015–1016 ion/cm2, the formation of dislocation defects is observed, the density of which has a pronounced dependence on the irradiation temperature. At irradiation fluence above 5 × 1016 ion/cm2, an increase in the crystal structure deformation is observed, due to swelling processes as a result of implanted hydrogen accumulation in the near-surface layer structure. At the same time, an increase in the irradiation temperature leads to a decrease in the swelling value, which is due to the accelerated migration of implanted hydrogen in the near-surface layer and its release through the existing pores. Results of mechanical tests showed that the swelling of the crystal structure and its deformation leads to embrittlement and a partial decrease in the strength of the near-surface layer. The obtained research results will further allow us to evaluate the resistance of lithium ceramics to the processes of hydrogenation and destruction as a result of the formation of gas-filled cavities in the structure of the near-surface layer.
Logistic Regression Model for a Bivariate Binomial Distribution with Applications in Baseball Data Analysis
Authors: Han Yewon , Kim Jaeho , Ng Hon Keung Tony , Kim Seong W.
Published: August 2022

There has been a considerable amount of literature on binomial regression models that utilize well-known link functions, such as logistic, probit, and complementary log-log functions. The conventional binomial model is focused only on a single parameter representing one probability of success. However, we often encounter data for which two different success probabilities are of interest simultaneously. For instance, there are several offensive measures in baseball to predict the future performance of batters. Under these circumstances, it would be meaningful to consider more than one success probability. In this article, we employ a bivariate binomial distribution that possesses two success probabilities to conduct a regression analysis with random effects being incorporated under a Bayesian framework. Major League Baseball data are analyzed to demonstrate our methodologies. Extensive simulation studies are conducted to investigate model performances.
Spectra of Self-Similar Measures
Authors: Cao Yong-Shen , Deng Qi-Rong , Li Ming-Tian
Published: August 2022

This paper is devoted to the characterization of spectrum candidates with a new tree structure to be the spectra of a spectral self-similar measure μN,D generated by the finite integer digit set D and the compression ratio N−1. The tree structure is introduced with the language of symbolic space and widens the field of spectrum candidates. The spectrum candidate considered by Łaba and Wang is a set with a special tree structure. After showing a new criterion for the spectrum candidate with a tree structure to be a spectrum of μN,D, three sufficient and necessary conditions for the spectrum candidate with a tree structure to be a spectrum of μN,D were obtained. This result extends the conclusion of Łaba and Wang. As an application, an example of spectrum candidate Λ(N,B) with the tree structure associated with a self-similar measure is given. By our results, we obtain that Λ(N,B) is a spectrum of the self-similar measure. However, neither the method of Łaba and Wang nor that of Strichartz is applicable to the set Λ(N,B).
Experimental Study on the Transient Disturbance Characteristics and Influence Factors of Pantograph–Catenary Discharge
Authors: Jin Mengzhe , Hu Man , Li Hao , Yang Yixuan , Liu Weidong , Fang Qingyuan , Liu Shanghe
Published: August 2022

The transient electromagnetic disturbance generated by arcing discharge between the pantograph and catenary can pose a significant risk to the safe operation of electrified railways. In order to better comprehend its properties, a pantograph–catenary discharge generating device is designed to simulate the discharge phenomenon with moving electrodes in this experimental investigation. The effects of the applied voltage, the gap distance, and the relative motion between the pantograph and catenary on the time- and frequency-domain features of the discharge current and electromagnetic field are investigated. The variation trends of pulse peak current, rise time, pulse repetition frequency, maximum amplitude, and characteristic frequency in the radiation spectrum are retrieved under varying experimental settings, and the effect mechanisms are derived from the physics of gas discharge. A dynamic discharge test is conducted in this study in order to further understand the effect of electrodes’ relative motion on discharge characteristics. The results indicate that lateral sliding motion of the pantograph along the track has a negligible effect on the transient discharge, whereas a faster vertical approaching motion between the pantograph and catenary generates a larger pulse current peak, a steeper rise front-edge, and a higher radiation intensity.
Battery Energy Storage for Photovoltaic Application in South Africa: A Review
Authors: Thango Bonginkosi A. , Bokoro Pitshou N.
Published: August 2022

Despite the significant slowdown of economic activity in South Africa by virtue of the COVID-19 outbreak, load shedding or scheduled power outages remained at a high level. The trend of rising load-shedding hours has persisted throughout most of the year 2022. Operational issues within the South African power utility inflamed the unpredictable nature of generation capacity, resulting in unscheduled outages at several generating units, mostly due to multiple breakdowns. To forestall substantial spikes in energy costs, an increasing number of enterprises and homeowners have started to gradually adopt renewable energy technologies to sustain their operational demand. Therefore, there is an increase in the exploration and investment of battery energy storage systems (BESS) to exploit South Africa’s high solar photovoltaic (PV) energy and help alleviate production losses related to load-shedding-induced downtime. As a result, the current work presents a comprehensive and consequential review conducted on the BESS specifically for solar PV application and in the South African context. The research investigations carried out on BESS for PV application are crucially examined, drawing attention to their capacities, shortcomings, constraints, and prospects for advancement. This investigation probed several areas of interest where the BESS-PV scheme is adopted, viz., choice of battery technology, mitigating miscellaneous power quality problems, optimal power system control, peak load shaving, South African BESS market and status of some Real BESS-PV projects. The techno-economic case scenario has been proposed in the current research and results yield that lithium-ion batteries are more viable than Lead–acid batteries.
Integer and Fractional-Order Sliding Mode Control Schemes in Wind Energy Conversion Systems: Comprehensive Review, Comparison, and Technical Insight
Authors: Sami Irfan , Ullah Shafaat , Khan Laiq , Al-Durra Ahmed , Ro Jong-Suk
Published: August 2022

The technological development in wind energy conversion systems (WECSs) places emphasis on the injection of wind power into the grid in a smoother and robust way. Sliding mode control (SMC) has proven to be a popular solution for the grid-connected WECS due to its robust nature. This paper reviews the enhancement trends in the integer-order SMC (IOSMC) and fractional-order SMC (FOSMC) schemes reported in reputed journals over the last two decades. This work starts with a mathematical description of the wind turbine, generators, grid, and SMC and its variants available in literature. A comprehensive literature review is tabulated that includes the proposed errors, sliding surfaces, typologies, and major outcomes. Moreover, a comparative analysis of the integer-order and fractional-order SMC and its variants is also presented in this paper. This paper will provide insight for the researcher working in the WECS and will serve them in the selection and exploration of the most appropriate control schemes for quality wind power extraction. The concise mathematical proofs of the IOSMC, FOSMC and their variants will also serve the researchers in selecting the relevant sliding surfaces control laws for their research tasks. This paper also provides a comparative analysis of IOSMC, FOSMC, and fuzzy-FOSMC in terms of chattering reduction, robustness, and computational complexities using mathematical theories, simulation carried out in Matlab/Simulink, and a processor in the loop (PIL)-based experimental environment.
Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer
Authors: Hu Zhiquan , Ma Siquan , Sun Yi , Long Gongwei , Chen Ke
Published: August 2022

The abnormal expression of long non-coding RNAs(lncRNAs) is closely related to the prognosis of patients. This finding may indicate a new target for the treatment of malignant tumors. Non-muscle invasive bladder cancer (NMIBC) is the most common subtype of bladder cancer, and BCG intravesical therapy is the first-line treatment for NMIBC, but about half of NMIBC patients relapse within two years after BCG treatment. Therefore, it is necessary to screen out lncRNAs related to the prognosis and treatment of BGC-resistant patients. Here, we performed differential expression analysis of lncRNAs in the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets, and screened MIR4435-2HG as the only BCG-response-related lncRNA. Then, the prognosis value of MIR4435-2HG was validated in several publicly available cohorts, and confirmed its prognostic value in bladder cancer of different stages. In addition, we also analyzed its genetic alterations, clinical relevance, function enrichment, and association with other biomarkers. Further validation of the expression of MIR4435-2HG might be helpful to instruct NMIBC prognosis and treatment.
Research Progress in J-Proteins in the Chloroplast
Authors: Zhao Lu , Jia Ting , Jiao Qingsong , Hu Xueyun
Published: August 2022

The J-proteins, also called DNAJ-proteins or heat shock protein 40 (HSP40), are one of the famous molecular chaperones. J-proteins, HSP70s and other chaperones work together as constitute ubiquitous types of molecular chaperone complex, which function in a wide variety of physiological processes. J-proteins are widely distributed in major cellular compartments. In the chloroplast of higher plants, around 18 J-proteins and multiple J-like proteins are present; however, the functions of most of them remain unclear. During the last few years, important progress has been made in the research on their roles in plants. There is increasing evidence that the chloroplast J-proteins play essential roles in chloroplast development, photosynthesis, seed germination and stress response. Here, we summarize recent research advances on the roles of J-proteins in the chloroplast, and discuss the open questions that remain in this field.
The Effect of Group Identification on Death Anxiety: The Chain Mediation Role of Close Relationships and Self-Esteem
Authors: Xiao Zilun , Zhao Yufang , Zheng Yingcan , Bao Yan , Zhang Chao
Published: August 2022

Based on the terror management theory (TMT), this study integrated self-esteem and close relationships to explore the effects of group identification on death anxiety. Five hundred and four participants completed the Death Anxiety, Rosenberg Self-Esteem, Social Identity, and Inclusion of Other in the Self scales via online platforms. There were significant correlations among group identification, close relationship, self-esteem, and death anxiety. Group identification had a significant negative predictive effect on death anxiety. Specifically, group identification affects death anxiety through two pathways: the separate mediating role of self-esteem and the serial mediation pathway of close relationships → self-esteem. Our study provides direct evidence that group identification relieves death anxiety. The results showed that the alleviating function of group identification was mediated by self-esteem and close relationships. This study provides a new perspective concerning TMT as a defense mechanism against death anxiety.
Reducing Anxiety and Social Stress in Primary Education: A Breath-Focused Heart Rate Variability Biofeedback Intervention
Authors: Aranberri-Ruiz Ainara , Aritzeta Aitor , Olarza Amaiur , Soroa Goretti , Mindeguia Rosa
Published: August 2022

Primary school students suffer from high levels of anxiety and stress. Having emotional regulation abilities can help them to manage challenging emotional situations. Conscious and slow breathing is a physiological, emotional regulation strategy that is feasible for primary school students to learn. Following Polyvagal Theory and PMER Theory, this research presents the results of a breath-focused heart rate variability biofeedback intervention. The intervention aimed to reduce anxiety and physiological and social stress in primary school children. A total of 585 students (46.4% girls and 53.6% boys) from the same public school, aged between 7 and 12 years (M = 8.51; SD = 1.26), participated in this study. To assess the impact of training, a mixed design was used with two groups (Treatment and Control groups), two evaluation phases (Pretest and Post-test), and three educational cycles (first, second and third cycles). To examine heart rate variability, emWave software was used and anxiety and social stress were measured by the BASC II test. The results showed that after the intervention, the students learned to breathe consciously. Moreover, they reduced their levels of anxiety (M(SD)pretest = 12.81(2.22) vs. M(SD)posttest = 13.70(1.98)) and stress (M(SD)pretest = 12.20(1.68) vs. M(SD)posttest = 12.90(1.44)). The work also discusses the limitations and benefits of this type of intervention in primary schools.
Career Capital and Well-Being: A Configurational Perspective
Authors: Xu Qian , Hou Zhe , Zhang Chao , Yu Feng , Li Tong
Published: August 2022

This study explored the configuration effect of human capital, social capital, and psychological capital on employee well-being. A total of 458 employees were investigated via a human capital scale, social capital scale, Chinese psychological capital scale, and multiple well-being questionnaire. The result of the fuzzy-set qualitative comparative analysis showed that human capital, social capital, and psychological capital in the form of diversified configuration will achieve high well-being, characterized by “all roads lead to Rome”. Even without human capital and social capital, high well-being can be achieved as long as psychological capital exists. Psychological capital is the most critical factor affecting subjective well-being, followed by human capital and social capital. Compared with guanxi-oriented psychological capital, task-oriented psychological capital is a more critical factor in achieving high well-being.
Does Cleaner Household Energy Promote Agricultural Green Production? Evidence from China
Authors: Li Fanghua , Liang Wei , Zang Dungang , Chandio Abbas Ali , Duan Yinying
Published: August 2022

Cleaner household energy for agricultural green production can significantly alleviate energy poverty and food security, thus contributing to global sustainable development. Using survey micro-data collected from Sichuan Province, the ordered probit model, OLS model, and instrumental variables approach were applied for empirical analysis. The results show that: (1) cleaner household energy significantly enhances farmer’s agricultural green production awareness and improves agricultural green production levels, which is still significant after treating endogenous issues with the conditional mixing process estimation method and 2SLS model; (2) health plays a partially mediating effect of cleaner household energy on agricultural green production awareness and agricultural green production levels; (3) environmental protection awareness and digital literacy have a moderating effect and reinforce the positive impact of cleaner household energy on agricultural green production awareness and agricultural green production levels. This research suggests that governments can enhance the impact of cleaner household energy on agricultural green production through price and subsidy mechanisms.
Is Dual-Task Training Clinically Beneficial to Improve Balance and Executive Function in Community-Dwelling Older Adults with a History of Falls?
Authors: Park Jin-Hyuck
Published: August 2022

Purpose: To date, the effects of dual-task training on balance underlying cognitive function remain unclear. Therefore, this study was to verify the effects of cognitive–physical dual-task training on balance and executive function in community-dwelling older adults with a history of falls. Method: Fifty-eight participants were randomly allocated to the experimental group (EG) receiving cognitive–physical dual-task training (n = 29) or to the control group (CG) receiving functional balance training (n = 29). After 12 sessions for 6 weeks, the One Leg Standing Test (OLST), the Timed UP and Go (TUG), and part B of the Trail-Making Test (TMT-B) were implemented to examine static and dynamic balance and executive function. Results: After the 12 sessions, the EG showed a greater improvement in the OLST (p < 0.001; η2 = 0.332), the TUG (p < 0.001; η2 = 0.375), and the TMT-B (p < 0.001; η2 = 0.224) compared to the CG. Conclusion: These results indicate that dual-task training is clinically beneficial to improving static and dynamic balance as well as executive function in older adults with a history of falls. These findings shed new light on a clinical implication that executive function should be considered in balance training for older adults.
Effects of Chinese Martial Arts on Motor Skills in Children between 5 and 6 Years of Age: A Randomized Controlled Trial
Authors: Li Bin , Li Ruijie , Qin Haiquan , Chen Tao , Sun Jingyu
Published: August 2022

Children’s motor skills can be fully developed only by the appropriate stimulation of physical activities and the environment, and the poor development of motor skills greatly increases the risk of cognitive impairment, obesity, and movement coordination disorder. This study aimed to examine the effects of Chinese martial arts on the motor skills of preschool children aged 5–6 years through a randomized controlled trial. A total of 87 children aged 5–6 years served as participants in a martial arts sensory teaching group (MAST, n = 29), a martial arts traditional teaching group (MATT, n = 29), and a free activity group (FA, n = 29). The interventions were conducted twice weekly for a total of 10 weeks, with each session lasting 30 min. Children’s motor skills were assessed before and after the intervention using the Movement Assessment Battery for Children (MABC-2). The results indicated that the balance index scores in the MAST (p < 0.001) and MATT (p = 0.014) groups were significantly higher than those in the FA and that the MAST score was significantly higher than the MATT (p = 0.004). Meanwhile, the MAST was significantly higher in total scores on motor skills when compared to the FA (p = 0.039), and the MAST showed significantly higher scores on manual dexterity when compared to both the MATT (p = 0.021) and FA (p = 0.011). Chinese martial arts can significantly improve the balance ability of preschool children, and the MAST method was found to be better than that of the MATT. Meanwhile, the MAST had good potential for the development of preschool children’s manual dexterity and their overall level of motor skills.
Infectious Diseases Associated with Hydrometeorological Hazards in Europe: Disaster Risk Reduction in the Context of the Climate Crisis and the Ongoing COVID-19 Pandemic
Authors: Mavrouli Maria , Mavroulis Spyridon , Lekkas Efthymios , Tsakris Athanassios
Published: August 2022

Hydrometeorological hazards comprise a wide range of events, mainly floods, storms, droughts, and temperature extremes. Floods account for the majority of the related disasters in both developed and developing countries. Flooding alters the natural balance of the environment and frequently establish a favorable habitat for pathogens and vectors to thrive. Diseases caused by pathogens that require vehicle transmission from host to host (waterborne) or a host/vector as part of their life cycle (vector-borne) are those most likely to be affected by flooding. Considering the most notable recent destructive floods events of July 2021 that affected several Central Europe countries, we conducted a systematic literature review in order to identify documented sporadic cases and outbreaks of infectious diseases in humans in Europe, where hydrometeorological hazards, mainly floods, were thought to have been involved. The occurrence of water-, rodent-, and vector-borne diseases in several European countries is highlighted, as flooding and the harsh post-flood conditions favor their emergence and transmission. In this context, strategies for prevention and management of infectious disease outbreaks in flood-prone and flood-affected areas are also proposed and comprise pre- and post-flood prevention measures, pre- and post-outbreak prevention measures, as well as mitigation actions when an infectious disease outbreak finally occurs. Emphasis is also placed on the collision of floods, flood-related infectious disease outbreaks, and the evolving COVID-19 pandemic, which may result in unprecedented multi-hazard conditions and requires a multi-hazard approach for the effective disaster management and risk reduction.
Identifying and Evaluating the Essential Factors Affecting the Incidence of Site Accidents Caused by Human Errors in Industrial Parks Construction Projects
Authors: Rafieyan Adel , Sarvari Hadi , Chan Daniel W. M.
Published: August 2022

In terms of safety management, the implementation of industrial parks construction projects (IPCPs) is incredibly challenging due to the special working conditions and the specific type of use of the buildings. On the other hand, the possibility of causing accidents in these areas based on human errors is high and important for project execution due to the risks of human errors and financial losses. Therefore, this study tries to fill this existing research gap by identifying and evaluating the effective key factors leading to the occurrence of construction accidents caused by human errors in the development of IPCPs. After a holistic review of the reported literature, four rounds of fuzzy Delphi survey were launched to capture the individual opinions and feedback from various project experts. Accordingly, 41 key factors affecting human errors in the implementation of industrial parks construction projects in Iran were identified and classified into nine main groups of wrong actions, observations/interpretations, planning/processes, equipment, organization, individual activities, environmental conditions, rescue, and technology. Then, the step-wise weight assessment ratio analysis (SWARA) method was adopted to rate and rank the identified factors of human errors in the implementation of IPCPs in Iran. The research findings indicated that among the elicited factors, time factor (0.1226), delayed interpretation (0.1080), and incorrect diagnosis/prediction (0.0990) are the three most crucial factors leading to human errors in the implementation of IPCPs in Iran. The results of this research study have provided various major project stakeholders with an effective decision-aid tool to make better-informed decisions in managing and reducing the occurrence of construction site accidents particularly caused by human errors associated with IPCPs.
Multi-Sector Assessment and Client-Perception of Social Need at Long-Term Follow-Up of a Group-Randomized Trial of Community-Engaged Collaborative Care for Adults with Depression
Authors: Barceló Nicolás E. , Castillo Enrico G. , Ijadi-Maghsoodi Roya , Goodsmith Nichole , Tang Lingqi , Okikawa David , Jones Felica , Williams Pluscedia , Benitez Christopher , Chung Bowen , Wells Kenneth B.
Published: August 2022

Understanding client perceptions of need for underlying social determinant support may improve services for depression care. This secondary analysis examines perceptions of “social needs” related to housing and employment, financial, and legal (EFL) concerns among individuals with depression. Data were analyzed from Community Partners in Care, a randomized comparative effectiveness trial of multi-sector collaborative care for depression among a sample of people who were predominantly racial/ethnic minorities and low-income. Adults with depression (n = 980) in both interventions were surveyed at 36-month follow-up for (1) being asked about and (2) having social needs for housing or EFL concerns. In multivariate models, life difficulty and mental health visits in non-healthcare sectors predicted being asked about housing and EFL. Lower social determinants of health-related life satisfaction increased the odds of having unmet housing and EFL needs. These findings underscore the role of non-healthcare organizations as community resources for depression care and in screening and addressing social needs.