bluuebunny/crossref_metadata_2025 huggingface dataset:
NARRATIVE ETHOS OF CONSCIENCE
Authors:   Russian State University for the Humanities, Tiupa Valerii I.
Published: February 2024

The article is about one of the little researched narratological categories, brought into narratology from rhetoric. Against the background of the historically most productive ethos of rest, duty and desire, attention is focused on the ethos of conscience, which has not been previously studied in narratology. Conscience is first discovered as an ethos in the narratives of the New Testament. In fiction, the ethos of conscience was clearly manifested in the Russian classical novel (especially by Dostoevsky). The ethos of conscience is also found in modern novelism, which does not break with classical traditions
V.S. GROSSMAN’S MILITARY JOURNALISM OF THE SECOND HALF OF 1944
Authors:   Russian State University for the Humanities, Bit-Yunan Yury G. ,   The Russian Presidential Academy of National Economy and Public Administration
Published: February 2024

The article studies and comments some of military essays written by a famous Soviet novelist and war correspondent V.S. Grossman in the second half of 1944, during a Red Army offensive. The texts are cited from newspapers and journals of that era.
Korekta map katastralnych na obszarze po eksploatacji górniczej
Authors: STANICZKOVÁ Marcela , HULANOVÁ Martina , KUTIL Lukáš , ČERNOTA Pavel , STAŇKOVÁ Hana
Published: February 2024

W artykule omówiono możliwości korekty mapy katastralnej na terenie pogórniczym. Jako obszar modelowy wybrano obszarkatastralny Muglinov w gminie Ostrawa. Problem niedokładności map wynika z wpływu podziemnej eksploatacji górniczej i rozwojuhistorycznego.Z technicznego punktu widzenia sposób korekcji, polegający na pomiarze większej liczby identycznych punktów, wykorzystaniuwspółrzędnych położenia punktów przemieszczonych z okresu po ustąpieniu wpływów górniczych i przekształceniu blokamiz wykorzystaniem transformacji Junga, w sposób zastosowany przy przywracaniu rejestru katastralnego poprzez przetworzeniewydaje się wykonalny i daje dobre rezultaty.
Manajemen Pengendalian Gulma Tanaman Cengkeh (Syzygium Aromaticum L.) Di Kebun Branggah Banaran, Blitar
Authors: Darin Sabaiq Yuhfadh Djiwangga , Zaman Sofyan , Budiman Candra
Published: February 2024

Gulma sangat berpengaruh terhadap produktivitas yang ada di lahan perkebunan termasuk pada komoditas cengkeh. Penurunan produksi diakibatkan karena adanya kompetisi nutrisi antara tanaman utama dan gulma. Penelitian bertujuan untuk menganalisis proses pengendalian gulma di Kebun Branggah Banaran, Blitar terutama mengenai manajemen pengendalian gulma tanaman cengkeh. Penelitian dilaksanakan pada bulan Januari hingga Mei 2022. Kondisi gulma di Kebun Branggah Banaran pada golongan tanaman B2, C1 dan C2 didominasi oleh gulma rumput Digitaria sanguinalis dan Pseudelephantopus spicatus pada golongan tanaman A1, A2 dan B1. Pekerja pengendalian gulma masih banyak yang belum mematuhi kelengkapan APD yang ditetapkan perusahaan. Perbandingan efektivitas biaya pengendalian gulma pada TBM dan TM menunjukkan bahwa metode kimiawi lebih efektif dengan rasio sebesar 1.24:1. Keberagaman gulma setiap tahun pangkas mempengaruhi kegiatan pengelolaan kerja pengendalian gulma secara umum. Keberagaman gulma mempengaruhi waktu pengendalian, metode pengendalian, kemampuan penyemprot serta efisiensi biaya pengendalian.

Kata kunci: analisis vegetasi, cengkeh, efektivitas biaya, gulma, herbisida
Model Pengelolaan Aset Ilmiah Digital Unpad Serta Akselerasi Layanannya
Authors: Yulianti Yulianti , Rakhmiyati Sri - , Erwina Wina -
Published: February 2024

Kajian ini bertujuan untuk menganalisis dan membuat bisnis proses pengelolaan aset ilmiah digital ideal di UNPAD. Pertanyaan penelitian adalah bagaimana pengelolaan aset ilmiah digital UNPAD. Identifikasi masalah yaitu: 1) Bagaimana analisis pengelolaan aset ilmiah digital di UNPAD?; 2) Bagaimana bentuk rancang bangun model proses bisnis pengelolaan aset ilmiah digital ideal di UNPAD?, dan 3) Bagaimana upaya apa yang dilakukan untuk meningkatkan kualitas layanan di masa pandemi? Metode penelitian adalah kualitatif deskriptif, dengan pendekatan studi kasus. Pengumpulan data dilakukan dengan cara wawancara, studi literature, analisis situasi dan observasi lapangan. Data primer yaitu hasil wawancara dan survey kepada pustakawan pengelola repository di lingkungan UNPAD. Total informan adalah 19 orang. Sedangkan data sekunder adalah hasil analisis lapangan dan studi dokumentasi. Hasil penelitian sudah dilakukan analisis serta penyusunan proses bisnis terkait pengelolaan asset ilmiah digital ideal di UNPAD. Kesimpulan bahwa pengelolaan asset ilmiah digital di Unpad serta proses bisnis harus ditindaklanjuti dengan penyusunan panduan dan SOP yang jelas yang bisa dijadikan panduan oleh seluruh civitas dan unit kerja di UNPAD. Saran penelitian ini adalah perlunya menyusun SOP keseluruhan yang melibatkan semua unit kerja, peresmian proses bisnis menjadi baku serta peningkatan konten di portal asset ilmiah Unpad (repository) Kata kunci :  repository, bisnis proses repository, Digital Scientific Assets (DSA), UNPAD
Diálogos interdisciplinares 10
Authors: Azevedo Amanda Fernandes de , Galaxe Fabiani Pereira Rueles , Silva José Geraldo Ferreira da , Jesus Anderson Silva de , Moura Luciana Teles , Terra Claudia Marcia Fricks Jordão Belonia , Mota Cristiane Aparecida Chaves , Barreto Sônia Maria da Costa , Portes Cristiani Soeiro Vieira , Nunes Marcus Antonius da Costa , Costa Daiana da Cunha Cavalini , Rangel Mayara Alves , Costa Dinalva Silva Cordeiro da , Garcia Anilton Salles , Ramos Elaine Machado Gomes , Backer Millk Sirregima Gomes de Menezes , Costalonga Silvana Mara Jordao , Viana Fabricio Barreto , Fernandes Fernnanda Luciano , Miranda João Alberto , Costalonga Juliana Pereira , Lago Vivian Miranda , Rissi Juliete , Santiago Magda da Silva , Santana Patrícia Vieira , Mattos Luiz Augusto da Cruz , Cabellino Micheline Scheidegger Fricks , Matos Samira da Silva , Santos Tiaria Graça dos , Nogueira André L. L. , Neves Vanessia Santana , Santos Giliane Sant Ana Mateus , Mateus Alessandra Sant Ana , Rainha Viviani de Almeida Terra , Colodetti Vânia Ferreira de Almeida
Published: February 2024

A publicação objetiva compartilhar as pesquisas, realizadas por alunos, com o acompanhamento de seus professores-orientadores, no Mestrado em Ciência, Tecnologia e Educação do Centro Universitário Vale do Cricaré (UNIVC), com o objetivo de desvelar a construção do saber, consolidado no âmbito acadêmico.
DEBATES EDUCACIONAIS CONTEMPORÂNEOS: direitos humanos, docência, inclusão, participação política e inteligência artificial no século XXI
Authors: Gabriel Ana Cássia , Pereira Ana Lúcia , Rocha Camarriry França , Silva Cleonice Elias da , Oliveira Debora Campiotto de , Ferreira Diego Augusto Gonçalves , Sloniak Emely Andrieli Gonçalves , Gabriel Fábio Antônio , Moreno Jean Carlos , Oliveira José Adriano de , Cirelli Lucas Frabi , Braga Lucimar Araujo , Filomeno Lucimar , Amaral Manoel Francisco do , Bezerra Marcos Sales , Corrêa Marjorie Bier Krinski , Gomes Rafaéla Pavéglio , Souza Rebeca Almeida de , Santos Sandra Analia dos
Published: February 2024

A obra é caracterizada pela preocupação dos diferentes autores nos mais diversos aspectos que assentam a educação e, em especial, o cenário da sala de aula. Nela, o leitor poderá encontrar discussões que versam sobre experiências didáticas, nas quais partimos desde a introdução de textos, a questão da introdução da inteligência artificial, até a curricularização dos conteúdos de uma sala de aula. Passamos pela problematização dos direitos humanos, os quais em mundo globalizado e multifacetado é de suma importância, para a discussão da relevância da educação especial no mundo escolar atual, no qual a inserção de alunos com necessidades educacionais especiais se apresenta a cada dia mais desafiador.
CONTROLLING AS A COMPONENT OF PROJECT MANAGEMENT IN AGRO-INDUSTRIAL PRODUCTION
Authors: Nosach Nataliia , Druhova Olena , Klepikova Svitlana
Published: February 2024

The subject of the research is the study of controlling as an integral part of project management in agricultural production. Methodology. The study used general scientific methods, in particular: theoretical generalisation; methods of analysis and synthesis; statistical analysis; graphical method (for visual display of the study results). The article presents results of substantiation of expediency of application of controlling in management of agricultural production projects. Сonclusion. Project management controlling is an essential tool for achieving success and sustainability in the implementation of projects, carrying out systematic planning, control and analysis of economic activities at the level of the entire organisation. The cooperation between controlling and project management is crucial for the effectiveness and efficiency of projects, and the implementation of controlling is a strategic step to achieve common strategic goals and increase the sustainability of the activity. Project management in agriculture requires specific approaches, and controlling is vital to achieving successful results. The key aspects of controlling are financial monitoring, adaptation to seasonality and project cycles, quality and standards monitoring, risk management and consideration of environmental approaches. Five key elements of project management controlling in the agricultural sector determine the effectiveness of project implementation. The schedule allows for accurate resource planning and control over project execution. Effective resource management helps to stay within the budget, risk analysis helps to avoid negative impacts, change control prevents unexpected expansion of the project scope, and measuring performance against critical indicators allows to evaluate project performance. The system of controlling is manifested in the union of all subsystems and blocks of controlling, where their interaction is aimed at the strategic goals of the company. This approach takes into account the importance of system integration and alignment with strategic goals for successful business management.
THE POTENTIAL FOR ENSURING FOOD SECURITY IN UKRAINE IN THE CONTEXT OF THE ONGOING MILITARY CONFLICT
Authors: Podsokha Anna , Havrylchenko Olena , Cherednyk Anna
Published: February 2024

The subject of the research is the study of Ukraine's food security and the potential for improving it. Methodology. The article uses general scientific and specific methods of economic research: the method of content analysis (when processing scientific sources and reviewing the thematic literature, deduction and induction); abstract and logical method (when identifying problematic aspects of ensuring the country's food security, substantiating conclusions and proposals); the method of statistical calculations of regression economics (when substantiating the economic and mathematical model of food security, calculating the indicator of the actual state of self-sufficiency in food security). The purpose of the study is to assess the level of food security achieved by Ukraine and to identify the main factors that affect the potential for its possible improvement. Conclusion. Ukraine has significant potential to ensure food security at the national and European levels. However, over the past two years, Ukraine has lost its position in the global food security ranking according to the GFSI. The main problematic aspects that led to this are as follows: irrational use of land and labour resources, aging and migration of the rural population; sharp loss of agricultural biodiversity; high level of chemicalisation of agricultural production; loss of the potential for quality reproduction of agricultural land; significant inclusive gaps within rural areas; low level of funding for agricultural science and a predominantly raw material, agrarian orientation. The main reason for the downgrade of Ukraine's GFSI rating in 2022 was the ongoing military operations in the country. Despite the existing problematic aspects, the Ukrainian agricultural sector showed the highest level of sustainable development compared to other types of economic activity. The share of profitable enterprises in the sector was 79%. Ukraine is currently self-sufficient in food security for almost all types of agricultural products. The constructed economic-mathematical model showed a high degree of dependence of food security on such factors as the total value of assets of agricultural formations, the value of fixed assets and the amount of profit. It was determined that the key condition for increasing the potential for ensuring food security in Ukraine, both at the national and European level, should be the social responsibility of agribusiness and raising the level of sustainable development of agriculture and rural areas.
THEORETICAL FOUNDATIONS OF CRIMINALISATION AND DECRIMINALISATION OF ACTS IN THE FIELD OF ECONOMIC RELATIONS
Authors: Baranenko Dmytro , Nabokova Olha , Lagoda Kateryna
Published: February 2024

The subject of the study is the public relations of criminalisation and decriminalisation of acts in the sphere of business-economic relations. Methodology. The methodological basis of the research is the method of induction and deduction, the dialectical-materialist method, the method of analysis and synthesis, the historical method, which allowed an objective understanding of the content and essence of the studied issues. The purpose of the article is to analyse the theoretical aspects of criminalisation and decriminalisation of acts in the sphere of business-economic relations in Ukraine in order to propose effective ways to improve the mechanism of these procedures in relation to business entities. The results of the study have shown that criminalisation and decriminalisation of economic activity in the economy of Ukraine as a vector of criminal policy and the direction of economic development of the state presupposes the formation of an effective model of interaction of economic entities among themselves and with the state, which minimises the commission of socially dangerous acts, meets the modern needs of society and is regulated by the norms of law. Conclusion. The importance of a systematic approach to decisions on criminalisation and decriminalisation of economic crimes was noted. It is argued that it is necessary to create a model of lawful behaviour in the economic sphere (the task of regulatory legislation) and to categorise deviations from this behaviour according to the degree of danger to the public, with the most dangerous acts being criminal offences. It is noted that the use of this approach will allow achieving the maximum corrective effect: the development of the Ukrainian economy and its eventual decriminalisation. It is emphasised that the role of criminal law in the regulation of socio-economic relations is far from leading. At the same time, the removal or installation of certain barriers for entrepreneurs cannot be considered as the ultimate goal of criminalisation or decriminalisation of acts in the field of business in criminal law. It is stated that criminal law should pursue the achievement of its preventive objectives, including in the fight against the black economy. The decriminalisation of offences against the economic order should be accompanied by changes in regulatory legislation in the direction of simplifying its requirements for business entities. Situations are unacceptable if, on the one hand, the rules and procedures for carrying out economic activities are complicated by regulatory legislation and, on the other hand, criminal liability for violating strict rules is eliminated. This leads to a very negative result: restrictions are circumvented because there is no responsibility for violating them.
UKRAINIAN LOCAL GOVERNMENT, HUMAN RIGHTS PROTECTION AND COUNCIL OF EUROPE STANDARDS: THE PRINCIPLE OF SUBSIDIARITY
Authors: Barvinenko Vitalii , Hedulianov Vadym , Mishyna Natalia
Published: February 2024

This article holds considerable significance as it thoroughly analyses the combination of local governance, human rights protection and the implementation of the principle of subsidiarity in Ukraine. It offers valuable insights into the complex dynamics between these components within the Council of Europe standards. The study of the principle of subsidiarity in the context of human rights at the local level makes a significant contribution to the broader discourse on good governance and legal frameworks. The primary objective of the article is to provide a thorough and nuanced understanding of the complex interplay between municipal human rights, the principle of subsidiarity, and the involvement of local and international entities in the protection of human rights in Ukraine. The study aims to achieve several goals: to delve into the principle of subsidiarity, to critically evaluate inaccuracies in the legal literature, and to highlight the role of the Council of Europe in promoting the principle of subsidiarity in the Ukrainian context. The research methodology is a mixture of legal analysis and conceptual exploration. In terms of the literature review, the article draws on the insights of various legal scholars and experts, including but not limited to B. Kofman, A. Krusyan, S. Kvitka, among others. Existing legal literature and academic works are reviewed in order to gain perspectives from different viewpoints, theories and analyses relevant to the research topic. Conclusion. This paper affirms that the Council of Europe and its member states follow the principle of subsidiarity in the protection of human rights at the local level. This involves a deliberate focus on the delineation of competences within local self-government and the provision of complementary (subsidiary) protection through the mechanisms of the European Court of Human Rights. The following sections explore various facets of the article in detail, offering a comprehensive analysis of the localisation of human rights protection, the complexities of subsidiarity in Ukrainian legal literature, and the crucial role played by the Council of Europe in promoting subsidiarity through various mechanisms.
Properties of elephant grass made particleboards: Influence of a hardener
Authors: Prosper Mensah  , Francis Kofi Bih  , Emmanuel Okumi-Andoh
Published: February 2024

The objective of the study was to assess the performance of one of the most abundant raw materials on Earth – the Elephant grass, for the production of particleboard bonded using cassava starch blended with Aluminium sulphate (Al2(SO4)3) as hardener. The physical, mechanical and decay properties of the manufactured particleboards were analyzed and compared with EN 312-2 (2005) and ANSI A208.1 (1999) standards for particleboards. The characterization also included thermogravimetric analysis and scanning electron micrographs. The results showed that the interaction of the Aluminium sulphate (Al2(SO4)3) hardener and the adhesives in the particleboard significantly affected the physical, mechanical, thermogravimetric and the decay properties of the manufactured particleboards. The particleboards with only Cassava starch as adhesive recorded 11.14% and 24.84% for 24-hour water absorption and thickness swelling respectively. However, with the blending of the adhesive with Al2(SO4)3, Cassava starch recorded 20.51% better for 24-hour WA and 35.62% better for 24-hour TS. Urea formaldehyde as an adhesive blended with the hardener also recorded better performance in the 24-hour dimensional stability property assessment. Similar trends of enhanced property performance were observed for the intended properties tested when Al2(SO4)3 is added to each adhesive. Static bending, hardness, internal bond strength, dimensional stability, thermogravimetric and decay resistance properties of the test particleboard improved with the addition of Al2(SO4)3.
Quantum computing and its potential impact on U.S. cybersecurity: A review: Scrutinizing the challenges and opportunities presented by quantum technologies in safeguarding digital assets
Authors: Enoch Oluwademilade Sodiya  , Uchenna Joseph Umoga  , Olukunle Oladipupo Amoo  , Akoh Atadoga
Published: February 2024

This study explores the dual impact of quantum computing on cybersecurity, focusing on the challenges it poses to existing cryptographic standards and the opportunities it presents for enhancing secure communication. Through a comprehensive review of current literature and analysis of emerging quantum-resistant technologies such as Quantum Key Distribution (QKD) and Post-Quantum Cryptography (PQC), the research identifies key vulnerabilities in traditional encryption methods and outlines the potential of quantum technologies to revolutionize cybersecurity practices. The study emphasizes the urgent need for the development and standardization of quantum-resistant cryptographic solutions to safeguard digital assets against the computational capabilities of quantum technologies. Policy recommendations are psroposed to accelerate the adoption of quantum-safe standards and to foster collaboration among stakeholders in the cybersecurity ecosystem. Furthermore, the study highlights areas for future research, including the scalability of quantum-resilient solutions and the ethical implications of quantum computing on privacy and security. Conclusively, the findings suggest that a proactive and collaborative approach is essential for navigating the quantum computing era, underscoring the importance of preparing a quantum-resilient cybersecurity infrastructure to ensure the long-term security of digital communications and assets.
Biochemical analysis of Justicia carnea leaves used as a hematinic
Authors: Andrew Chimezie Andrew  , Reginald Nwazue Nwaoguikpe  , Cosmas Onyekachi Ujowundu  , Favour Ntite Ujowundu
Published: February 2024

Justicia carnea is the largest genus of Acanthaceae and is a medicinal plant used widely in Nigeria, reported to have diverse functions, including blood-boosting potential. The phytochemicals, vitamins, minerals, amino acid and proximate compositions of the leaf extract of Justicia carnea were determined using standard methods. Results of the quantitative phytochemical analyses on the leaves of Justicia carnea recorded appreciable presence of flavonoids, alkaloids, saponins, tannins, cyanogenic glycosides, oxalate, and phytate using GC-FID. Ribalinidine with 42.08±0.03 mg/kg was the highest alkaloid, Flavan -3-ol was 21.18±0.02 mg/kg, presented the highest amount of flavonoids, and phytate with 25.69±0.07 mg/kg as the highest antinutrient. Analysis of Justicia carnea leaves recorded iron (8.61mg/kg) as the major elemental content followed by potassium (5.29±0.11mg/kg). The concentrations of vitamins in Justicia carnea leaves showed vitamin C, with the highest value of (232.32±12.26 mg/100g) followed by Vitamin A (22.16±2.12 mg/kg). The results of proximate composition on Justicia carnea leaves showed a high concentration of carbohydrate (60.35±3.05%) and appreciable amounts of ash (15.02±1.01%), fibre (9.29±0.93%), protein (8.40±0.41%), and low amount of lipid (1.50±0.09%). The amino acid results showed the presence of both essential and non-essential amino acids with their concentrations in increasing and decreasing orders. These results obtained showed that leaves of Justicia carnea may serve as rich source of natural antioxidants, this may be attributed to its rich phytochemicals, nutrients and vitamin compositions and could be recommended as a potential source of useful bioactive constituents as vegetable supplement and has no toxic effect and as an effective hematinic supplement when prepared adequately.
Evaluation of the nutritional potentials of Lageneria breviflora seeds
Authors: Ogechukwu E. Ezim  , Franca N. Okoye  , Victor S. Krukru  , Enyinnaya A. Ogbonnaya
Published: February 2024

The proximate, phytochemicals, volatile organic compounds and mineral compositions of Lageneria breviflora seeds were evaluated in this study using standard methods. The results showed appreciable amount of nutrient. Proximate composition showed that the seed contains 54.87% carbohydrate, 15.37% fat and 3.65% crude protein. Anthocyanin (77.55µg/g) had the highest concentration among the phytochemicals present. Majority of the phytochemicals that were predominantly present were of flavonoid class. Oxalate, tannin, and alkaloid were found in appreciable quantities. The following volatile organic compouds were detected acetone, acetic acid, butanal, formaldehyde, methane, benzene, xylene, toluene, and monoterpenes. The analysis of the mineral showed appreciable amount of minerals with magnesium having the highest amount(15.263ppm). Lageneria breviflora seed is a potential source of important nutrients and pharmacological compounds.
Gravity-driven crossflow membrane filtration and mechanical centrifugation yield plasma with equivalent total and COVID-19-specific immunoglobulin content
Authors: Rosita Bihariesingh-Sanchit  , Rakesh Bansie  , Shannon Tjon A Sam  , Cheneal Lieveld  , Anoushka Simons  , Jimmy Kromosoeto  , Sjef J.C.M. van de Leur  , Stephen C. Vreden  , Zaheeb Choudhry  , Angélique B. van ‘t Wout  , Marien I. de Jonge  , Dimitri A. Diavatopoulos  , Arno P. Nierich
Published: February 2024

While the administration of convalescent plasma is a promising therapy for coronavirus disease 2019 (COVID-19), upfront costs and technological barriers of conventional plasmapheresis have limited the collection and processing of COVID-19 convalescent plasma (CCP) in Low- and Middle-Income Countries (LMICs). We previously reported that bedside plasma separation using gravity-driven microfiltration has made CCP therapy accessible as a treatment option in Suriname. However, the question remains whether the gravity-driven microfiltration method yields similar amounts of immunoglobulins as compared to conventional plasmapheresis. Here, we compared the gravity-driven microfiltration method with conventional plasma centrifugation for the total and COVID-19-specific immunoglobulin content of the obtained CCP. Blood donations from 10 donors recovered from PCR-confirmed COVID-19 were processed using both methods. Samples were collected pre- and post-processing for analysis to allow direct comparison of both methods. There were no differences in COVID-19-specific IgG levels between convalescent plasma obtained by microfiltration and centrifugation for 4 of the 5 assays used. Anti-RBD-Omicron IgG levels were slightly higher in the plasma obtained after filtration (median 274, range 69 to 1258) than after centrifugation (median 249, range 67 to 1175), Wilcoxon P = 0.0488. No significant differences were detected between the two methods for levels of total albumin, total cholesterol, total IgA, IgM and IgG levels. These results indicate that gravity-driven microfiltration and conventional centrifugation yield CCP with equivalent amounts of total and COVID-19-specific antibodies. This makes the gravity-driven microfiltration method a viable option for the collection and treatment with CCP in the LMICs setting.
Effects of combination of tramadol and sildenafil citrate (Viagra) on hepatic and renal function parameters in Male Albino Rats
Authors: Ojoye N. Briggs  , Kemzi N. Elechi-Amadi  , Jack G. Tetam  , Tarila N. Aleruchi-Didia  , Woka P. Uchechukwu
Published: February 2024

Erectile dysfunction, premature ejaculation and pleasure seeking have increased the use of sildenafil citrate, tramadol and their combination by youths who believe these drugs could positively impact their sexual life. Sildenafil citrate and tramadol are metabolized in the liver, and their by-products excreted through the kidneys, making these organs possible targets for toxicity. Aim: This study evaluates the effects of combination of tramadol and sildenafil citrate on hepatic and renal function parameters in male albino rats. Methodology: A total of forty-nine (49) male albino rats weighing between 150 to 180g were used for the study. Sildenafil citrate and tramadol were administered to the rats by means of oral gavage for 28 days. The liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined using the Reitman-Frankel method. Alkaline phosphatase (ALP) was determined using the Colorimetric endpoint method. Total protein (TP) was determined using the biuret method. Albumin (ALB) was determined using the bromocresol green method. Sodium (Na+), potassium (K+) and chloride (CL-) were determined using ion selective electrode (ISE) method. Bicarbonate (HCO3-) was determined using titrimetric method. Urea was determined using Urease bertholet method. Creatinine was determined using Jaffe-Slot method. Results: There were no significant differences (P>.05) in the liver enzymes ALT, AST and ALP in all the treatment groups compared to the negative control. Total protein (TP) and albumin (ALB) also showed no significant differences (P>.05) in the groups, compared to the negative control. there were no significant differences (P>.05) in the electrolyte levels in the treatment groups, compared to the negative control. Urea and creatinine levels were also not significantly different (P>.05) in the treatment groups, compared to the negative control. Conclusion: Administration of sildenafil citrate singularly and in combination with tramadol, at recommended and double doses for 28 days, did not impact the liver and was also non-toxic to the kidneys.
Cannabis sativa: Cervical cancer treatment- Role of phytocannabinoids-A story of concern
Authors: Ravindra B. Malabadi  , Sadiya MR  , Prathima TC  , Kiran P. Kolkar  , Simuzar S. Mammadova  , Raju K. Chalannavar
Published: February 2024

This litrature review paper highlights the role of phytocannabinoids in controlling cervical cancer. Cervical cancer is one of the leading causes of cancer death among females worldwide. Cervical cancer (CC) is a malignant form of tumor which originates in the cervix. Cervical cancer, which develops in a woman’s cervix, is the second-most common cancer among women in India The causative agent of cervical cancer is persistent infection with high-risk subtypes of the Human Papillomavirus (HPV) and the E5, E6 and E7 viral onco-proteins cooperate with host factors to induce and maintain the malignant phenotype. Human papillomavirus (HPV) is responsible for subclinical/clinical lesions in cervical cancer. HPV types 16 and 18 are the most common HPV types identified in invasive cervical cancer. Currently, the recommended therapeutic regimens include chemotherapy, radiation therapy either alone or in combination and surgical interventions. However, they present several limitations including side effects or ineffectiveness. Medicinal plants including Cannabis sativa have been used for decades for health benefits and to treat several different diseases including cervical cancer. Cannabis has been used for thousands of years for recreational, medicinal, or religious purposes. Phytocannabinoids are cannabinoids that occur naturally in the cannabis plant. The two phytocannabinoids the most well known for their therapeutic properties are, Δ9-tetrahydrocannabinol (THC) and Cannabidiol (CBD). Cannabis and cannabinoids hold big promise for cancer therapy. However, there is a need to understand more about the role of Endocannabinoid system (ECS) in normal human physiology and malignant transformations. Molecular mechanisms of Endocannabinoid system (ECS) regulation and anticancer properties of cannabis also need to be clarified. The treatment durations in the existing trials are also of concern. Future epidemiological and clinical studies are required to further assess the benefits of herbal medicines for the prevention of cervical cancer. In addition, preclinical and human clinical trial evaluations of cannabis for cervical cancer treatment have not specifically been conducted, so further investigations related to this are warranted. Therefore, HPV immunization programme is the best ideal solution for the eradication of cervical cancer.
Stigma Pada Penderita Kusta Di Komunitas : A Systematic Review
Authors: Jatimi Atika , Holisun Holisun , Ahmadi Ahmadi
Published: February 2024

Individu yang terdiagnosa penyakit kusta di komunitas mengalami berbagai tekanan psikologis. Tekanan tersebut dapat berasal dari persepsi internal individu seperti merasa tidak percaya diri, merasa malu dan perasaan takut dijauhi. Selain itu tekanan psikologis yang dialami individu dapat bersumber dari faktor eksternal seperti perlakuan diskriminasi dari masyarakat, labeling serta isolasi dalam kehidupan sosial. Metode yang digunakan dalam penyusunan artikel ini ialah metode PRISMA dengan pencarian database meliputi Google Cendekia, Garba Rujukan Digital dan Science Direct. Terdapat 15 artikel terpilih berdasarkan kriteria yakni terbit tahun 2018-2023, dapat diakses fulltext, artikel berbahasa indonesia dan bahasa inggris serta merupakan penelitian kualitatif dengan menggunakan kata kunci stigma, penderita kusta, dan komunitas. Artikel yang telah dipilih kemudian dianalisis dengan hasil yang menunjukkan bahwa stigma yang dialami oleh penderita kusta di komunitas terdiri dari stigma terhadap diri sendiri dan stigma dari masyarakat. Stigma tersebut menjadi penyebab munculnya masalah psikologis pada penderita kusta.
GENERAL CONDITION ASSESSMENT METHOD FOR SIGNALIZED INTERSECTIONS: THE CASE OF IBAGUE, COLOMBIA
Authors:   Universidad de Ibagué, Programa de Ingeniería Civil, Facultad de Ingeniería, Ibagué, Colombia, GOMEZ Juan , TRIANA Karen ,   Universidad de Ibagué, Programa de Ingeniería Civil, Facultad de Ingeniería, Ibagué, Colombia, VARGAS Mario ,   Universidad de Ibagué, Programa de Ingeniería Civil, Facultad de Ingeniería, Ibagué, Colombia, ESCOBAR Diego ,   Universidad Nacional de Colombia sede Manizales, Departamento de Ingeniería Civil, Grupo de Investigación en Movilidad Sostenible, Manizales, Colombia, ZULUAGA-VILLERMO Juan ,   Universidad de Ibagué, Programa de Ingeniería civil, Grupo de Investigación MYSCO, Ibagué, Colombia
Published: February 2024

This study proposes a new method created to perform a universal assessment on the status of signalized intersections implemented in the city of Ibague, Colombia. The condition of each signalized intersection is classified according to parameters established to improve vehicular and pedestrian traffic, as well as the long-term development of the city. To achieve the research objective, the aspects to be evaluated are divided in two categories: Functionality and Utility, as well as specific criteria for each of them. Therefore, field data is collected using a geospatial tool and assigning levels of importance associated with a numerical scale that is plotted on maps of influence. We can therefore conclude that the proposed assessment method is not only necessary, but suitable for the evaluation of signalized intersections, which effectively assess the pertinent aspects, granting a rating supported by their respective analysis, and making the comparison of their specific conditions over time possible. For example, in the case study of Ibague 2023, according to the evaluation method, 59% of the intersections were ranked in the lowest states of the scale, also showing that between 2018 and 2023 there was an overall decay, as most of the intersections (85%) lowered their ratings and degraded to a greater extent compared to those with improvements.
Tirukkural, Quran and Old Testament: The Relationship between Greek Hippolytus, Hebrew Joseph, Arabic Yūsuf and Buddha with Chastity, Orphic and Sobriety
Authors: Pugazhendhi D
Published: February 2024

Hippolytus is a tale seen in ancient Greek literature. It deals primarily with the sexual desire of a stepmother towards her stepson. Euripides also wrote a play on this theme with the similar name. In this he mentioned familiarity in which the poet also can sing. Ancient Greek Historian Pausanias mentioned that the alien who has learnt Greek, knows about this tale. So it is a need to search, how far this tale could travel. Ancient Greeks traded with Tamil Nadu, India. The same tale is also seen in Indian Buddhist text, with other proper names, that mentioned the same is related with the former birth of Buddha. A similar story of Hippolytus is also found in the Hebrew Old Testament and the Arabic Qur'an. These also need comparison. So this study considered the religious value of this Greek tale ‘Hippolytus’. The chastity and vegetarianism of Hippolytus are mentioned as the best morals in an ancient book called Tirukkuṟaḷ, which is on par with Buddhist philosophy. This paper outcomes the concept of chastity and vegetarianism, mingled in the tale, which is the philosopy of Buddhism and how the Greek philosophy admired and induced the Indians to worship the Grecian Deities. Keywords: Tirukkuṟaḷ, Hippolytus, Tamil Nadu, Buddhism, Chastity, Quran, Old Testament
Assessing the influence of dopamine and mindfulness on the formation of routines in visual search
Authors: Garner Kelly , Leow Li-Ann , Uchida Aya , Nolan Christopher Raymond , Jensen Ole , Garrido Marta , Dux Paul Edmund
Published: February 2024

Given experience in cluttered but stable visual environments, our eye-movements form stereotyped routines that sample task-relevant locations, while not mixing-up routines between similar task-settings. Both dopamine signalling and mindfulness have been posited as factors that influence the formation of such routines, yet quantification of their impact remains to be tested in healthy humans. Over two sessions, participants searched through grids of doors to find hidden targets, using a gaze-contingent display. Within each session, door scenes appeared in either one of two colours, with each colour signalling a differing set of likely target locations. We derived measures for how well target locations were learned (target-accuracy), how routine were sets of eye-movements (stereotypy), and the extent of interference between the two scenes (setting-accuracy). Participants completed two sessions, where they were administered either levodopa (dopamine precursor) or placebo (vitamin C), under double-blind counterbalanced conditions. Dopamine and trait mindfulness (assessed by questionnaire) interacted to influence both target-accuracy and stereotypy. Increasing dopamine improved accuracy and reduced stereotypy for high mindfulness scorers, but induced the opposite pattern for low mindfulness scorers. Dopamine also disrupted setting-accuracy invariant to mindfulness. Our findings show that mindfulness modulates the impact of dopamine on the target-accuracy and stereotypy of eye-movement routines, whereas increasing dopamine promotes interference between task-settings, regardless of mindfulness. These findings provide a link between non-human and human models regarding the influence of dopamine on the formation of task-relevant eye-movement routines, and provide novel insights into behaviour-trait factors that modulate the use of experience when building adaptive repertoires.
Adjusted Network Loadings for Dynamic Exploratory Graph Analysis
Authors: Jamison Laura , Golino Hudson , Christensen Alexander P.
Published: February 2024

The possibility of computing network loadings in the context of Exploratory Graph Analysis (EGA) has been recently made possible. In the cross-sectional case, it has been demonstrated that network loadings have a linear, symmetric relationship to their corresponding true population loadings. However, in the dynamical case, the relationship between network loadings and true population loadings has yet to be fully investigated. The present study reveals an asymmetrical relationship between incremental changes in true population loadings and corresponding changes in network loadings, posing challenges to their interpretation. Adjustments to network loadings have been proposed to preserve the rank order of loadings while increasing their spread, thereby enhancing the interpretability and discriminability of network structures.
The Second Language Linguistic Perception Model (L2LP)
Authors: Escudero Paola , Yazawa Kakeru
Published: February 2024

In this chapter, we thoroughly describe the L2LP model, its five ingredients to explain speech development from first contact with a language or dialect (initial state) to proficiency comparable to a native speaker of the language or dialect (ultimate attainment), and its empirical, computational, and statistical method. We present recent studies comparing different types of bilinguals (simultaneous and sequential) and explaining their differential levels of ultimate attainment in different learning scenarios. We also show that although the model has the word “perception” in its name, it was designed to also explain phonological development in general, including lexical development, speech production, and orthographic effects. The studies reviewed in the chapter include new methods for examining lexical development and speech production, via implicit word learning and corpus-based analyses respectively, as well as a novel suprasegmental example of the L2LP SUBSET problem, which was conceptualized as the reverse of the commonly NEW scenario where L2 learners are phased with target contrasts that do not exist in their L1. We also review a recent study on the effect of bidialectalism on L2 acquisition, showing that the L2LP model’s explanations not only apply to speakers of multiple languages but also of multiple dialects. Finally, we present other topics and future directions, including phonetic training, going beyond segmental phonology, and the formalisation of orthographic effects in phonological development. All in all, the chapter demonstrates that the L2LP model can be regarded as a comprehensive theoretical, computational, and probabilistic model or framework for explaining how we learn the phonetics and phonology of multiple languages (sequentially or simultaneously) with variable levels of language input throughout the life span.
The Sampling Quadrangle Assemblages Research Experiment (SQuARE) on the International Space Station, Report 1: Squares 03 and 05.
Authors: Walsh Justin , Graham Shawn , Gorman Alice C. , Brousseau Chantal , Abdullah Salma
Published: February 2024

Between January and March 2022, crew aboard the International Space Station (ISS) performed the first archaeological fieldwork in space, the Sampling Quadrangle Assemblages Research Experiment (SQuARE). The experiment aimed to: (1) develop a new understanding of how humans adapt to life in an environmental context for which we are not evolutionarily adapted, using evidence from the observation of material culture; (2) identify disjunctions between planned and actual usage of facilities on a space station; (3) develop and test techniques that enable archaeological research at a distance; and (4) demonstrate the relevance of social science methods and perspectives for improving life in space. In this article, we describe our methodology, which involves a creative re-imagining of a long-standing sampling practice for the characterization of a site, the shovel test pit.The ISS crew marked out six sample locations (“squares”) around the ISS and documented them through daily photography over a 60-day period. Here we present the results from two of the six squares: an equipment maintenance area, and an area near exercise equipment and the latrine. Using the photographs and an innovative webtool, we identified 5,438 instances of items, labeling them by type and function. We then performed chronological analyses to determine how the documented areas were actually used. Our results show differences between intended and actual use, with storage the most common function of the maintenance area, and personal hygiene activities most common in an undesignated area near locations for exercise and waste.
Al-rich AlGaN Alloys: Unique Materials for Deep UV LEDs
Authors: Nakarmi Mim Lal
Published: February 2024

Energy bandgap of AlxGa1−xN alloys can be tuned systematically from ∼ 3.4 to 6.1 eV by changing the alloy composition (x) from 0 to 1 and the direct bandgap nature is maintained in the entire range of alloy compositions which make the AlGaN alloys suitable materials for the development of light emitting diodes (LEDs) covering the ultraviolet (UV) spectral region from 210 to 400 nm. For LEDs in the deep UV regions (λ < 300 nm), Al-rich AlGaN alloys of Al content higher than 50% are required. Deep UV LEDs have applications in a wide range of fields including display, disinfection, medical, sensing, and communication. With recent progress in the material growth and electrical conductivity, Al-rich AlGaN alloys have emerged as unique wideband gap materials for the development of deep UV LEDs. In this review article, how the progress of Al-rich AlGaN alloys has made in terms of the material growth and electrical conductivity leading its emergence as deep UV materials have been reviewed. Challenges and prospects of the deep UV LEDs to improve the performance of the devices will also be discussed.
EU-China Economic Relations in the Early 21st Century
Authors: Rahman Md. Sayedur , Habib Md. Tahosan
Published: February 2024

The European Union (EU) and China are two of the most influential and complex economies globally. The current state of their relationship is marked by a growing trade deficit for the EU with China, along with increasing Chinese investments in Europe's energy, technology, and infrastructure sectors. The EU has expressed dissatisfaction with China's treatment of foreign investors, limited market access for European companies, and government subsidization of domestic companies. Additionally, the EU has raised concerns about China's human rights record and its policies in Hong Kong, Taiwan, and mainland China. The partnership is expected to remain a key focus for the EU's economic outlook as both sides balance economic potential with geopolitical and security considerations. This report aims to identify and explain the primary issues, key areas for improvement, and mutual interests between the EU and China, while also proposing potential solutions to enhance their economic and trade relations. Informative articles, relevant papers, textbooks, and other sources support the discussion. Although the analysis is subjective, a quantitative methodology is also employed. The discussion presents a common interface and provides recommendations for enhancing financial relations, increasing exchange, financial and security relations, participating in and benefiting from two-way engagement, and enhancing EU-China relations.
Shifting Trends in Regionalism
Authors: Baral Bhim Nath
Published: February 2024

Regionalism is a movement that emerged after World War II. It involves countries that are geographically close and interdependent, collaborating with the help of governments and NGOs to achieve mutual benefits in a particular area of shared interest. Such regional clusters have evolved due to geographical proximity, economic interdependence, security issues, social and cultural background, and more. The end of the Cold War led to the rise of new regionalism shaped by factors such as globalization, the emergence of new players, shifts in global power dynamics, increased interdependence, alterations in security paradigms, the advent of multipolar, and various other influences. This shifting pattern has had a major impact on world politics and power dynamics. Traditional notions of security are evolving to encompass human security concerns, while economic collaboration and identity-based regionalism are gaining prominence. Asia's growing economic clout, new regional players' arrival, and smaller states' growing role are reshaping the global power landscape. Asymmetric positions and chequered history hinder the functioning of regionalism. In this context, the article seeks to analyze the changing dynamics of regionalism, the primary drivers of this shift, and its implications for global power dynamics. The article is presented from the perspectives of neo-realism, neo-liberalism, and constructivism in a descriptive, analytical, and exploratory format, where the necessary information is obtained from secondary qualitative data.