bluuebunny/crossref_metadata_2025 huggingface dataset:
A Research On The Fundamentals Of Management At The Organizational Level In The Context Of Hospital Management
Authors: İLHAN Ahmet
Published: June 2022

Hastaneler genel olarak faaliyet gösterdikleri toplum içinde daha kompleks ve dinamik özellikler sergileyen kurumlar arasında yer almaktadır. Özellikle hastane işletmeciliği yönetiminde örgütsel düzeyde yönetsel işleyiş ve alanların
yapısal özellikleri ön plana çıkmaktadır. Bu bağlamda sağlık kurumlarının örgütsel yapı ve tasarımı temel olarak yönetsel düzeyde rol dağılımı, yönetim alanları ve pozisyonları ile birimler arası yönetsel unsurların etkileşimleri
çerçevesinde ilerleyen bir süreç olarak ele alınmaktadır. Dolayısıyla sistem yaklaşımı, hastanelerin kompleks yapıda içsel ve dışsal ilişkilerini örgütsel düzeyde modelleyebilen bir anlayışı temsil etmektedir. Söz konusu sistem
yaklaşımı çerçevesinde hastane işletmeciliği yönetiminin örgütsel düzeyde performans, kalite, iletişim, verimlilik ve koordinasyon gibi bileşenlerle standardize edilebilecek yapılar haline dönüşebileceğini söylemek mümkündür. Buna
göre çalışmanın temel amacı hastane işletmeciliği bağlamında örgütsel düzeyde hastane organizasyonlarına yönetim temelleri açısından bakabilmenin yollarını açıklamak ve söz konusu bu durumu açıklayan rasyonel yaklaşım modelini
belirlemektir. Çalışma kapsamında elden edilen bilgilerin ışığında hastane işletmeciliğinde, hastane organizasyonlarına yönetim temelleri açısından sağlıklı bir işleyiş modeli çerçevesinde bakılabilecek olan rasyonel yaklaşımın
açık sistem yaklaşımı modelini olduğunu ileri sürebiliriz. Bu noktada sistem yaklaşımı çerçevesinde sunulan hizmetler kapsamında yönetim uygulamalarının rasyonel olarak hastane işletmeciliği yönetiminde örgütsel bir başarı elde
edilmesine katkı sunacağı düşünülmektedir.
Faktor-Faktor Penyebab Rendahnya Minat Melanjutkan Studi Anak Pada Masyarakat Nelayan di Desa Seruni Mumbul Kabupaten Lombok Timur
Authors: Asmiati Asmiati , Sumardi Lalu , Ismail M. , Alqadri Bagdawansyah
Published: June 2022

Pendidikan merupakan hak fundamental setiap orang yang wajib dipenuhi sebagaimana amanat dalam pembukaan Undang-Undang Dasar 1945 pada alinea ke-empat bahwa tujuan Negara Indonesia adalah memajukan kesejahteraan umum dan mencerdaskan kehidupan bangsa sehingga dapat memberikan akses pendidikan yang sama bagi setiap warga negara agar terbentuknya sumberdaya manusia yang memiliki kompetensi ilmu pengetahuan dan keterampilan. Tujuan diadakannya penelitian ini adalah untuk mengetahui apa saja faktor penyebab rendahnya minat melanjutkan studi anak pada masyarakat nelayan di Desa Seruni Mumbul dan upaya yang dilakukan oleh pemerintah desa untuk mengatasi rendahnya minat melanjutkan studi anak pada masyarakat nelayan di Desa Seruni Mumbul. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus. Teknik pengumpulan data menggunakan teknik wawancara tidak struktur dan dokumentasi. Hasil penelitian menunjukkan bahwa faktor-faktor penyebab rendahnya minat melanjutkan studi anak pada masyarakat nelayan di Desa Seruni mumbul yaitu: (1) Faktor internal yang meliputi: a. rendahnya motivasi dan minat anak untuk bersekolah, b. ketidakmampuan anak mengikuti pelajaran; (2) Faktor eksternal yang meliputi: a. Kondisi sosial ekonomi: tingkat pendidikan orangtua, pekerjaan dan pendapatan orangtua, dan keterlibatan anak dalam pekerjaan; b. Lingkungan sekolah; c. Kondisi sosial budaya: lingkungan tempat tinggal, pernikahan muda. Upaya yang dilakukan oleh pemerintah Desa Seruni Mumbul untuk mengatasi rendahnya minat melanjutkan studi anak pada masyarakat nelayan berupa upaya pencegahan anak putus sekolah dan upaya pengelolaan anak yang sudah putus sekolah, meski demikian belum memberikan hasil yang maksimal.
Pendampingan Masyarakat Dalam Perencanaan Pengembangan Masjid Al-Barkah, Cipedak, Ciganjur, Jakarta Selatan
Authors: Purwantiasning Ari Widyati , Bahri Saeful , Rafsyanjani Muhammad Akbar , Buana Muhammad Cakra
Published: June 2022

Kegiatan pendampingan masyarakat dalam pengembangan perencanaan Masjid Al-Barkah di Cipedak, Ciganjur, Jakarta Selatan ini merupakan kegiatan pengabdian pada masyarakat yang dilakukanoleh Program Studi Arsitektur, Fakultas Teknik, Universitas Muhammadiyah Jakarta. Kegiatan ini merupakan salah satu bentuk kepedulian Program Studi Arsitektur FT UMJ dalam upaya meningkatkan kualitas dan kemampuan masyarakat baik dalam menentukan keputusan dalam hal ini sebagai pemegang keputusan, maupun kemampuan dalam menerjemahkan sebuah kebutuhan ke dalam skematik disain. Pelaksanaan kegiatan ini bertujuan untuk mendampingi masyarakat khususnya para pengurus masjid dan pemangku keputusan di dalam msayarakat dalam memberikan solusi disain pada perencanaan pengembangan bangunan masjid yang semula hanya satu lantai menjadi dua lantai. Kegiatan pendampingan ini dilakukan dalam tiga tahapan kegiatan, tahap pertama meliputi observasi lapangan, kegiatan kedua berupa diskusi kelompok antar warga dan pengurus masjid dalam menentukan kebutuhan dan memberikan keputusan-keputusan terkait disain pengembangan dan tahap terakhir adalah eksekusi dari disain pengembangan perencanaan Masjid Al-Barkah yang dibantu oleh para mahasiswa Program Studi Arsitektur FT UMJ. Hasil akhir dari kegiatan pendampingan masyarakat ini diharapkan dapat memberikan pembelajaran bagi masyarakat dalam menentukan keputusan terkait dengan disain sesuai kebutuhan pengguna dalam hal ini tentunya masyarakat sekitar Masjid Al-Barkah.
Об основах развития экономики Азиатской России
Authors: Крюков В.А. , Суслов Н.И. , Ягольницер М.А.
Published: June 2022

В статье анализируется ресурсный потенциал территории Азиатской России, который наряду с минеральным сырьем и топливом включает биоресурсы, леса как источник рекреации и декарбонизации и само географиче- ское пространство. Обсуждаются исторически сложившиеся проблемы развития регионов, имеющие как объективную обусловленность, так и субъективную составляющую, вызванную порочностью подходов к управлению территорией. Слабая освоенность и связность пространства, суровый климат ведут к допол- нительным издержкам развития Азиатской России, в то же время для ускорения экономического роста в стране требуется быстрое развитие ее экономики. Предложен подход, основанный на концепции «большого инвестиционного импульса», который должен позволить усилить рост экономики территории. Рассмотрен ряд проектов черной металлургии, которые могут стать полигоном для реализации указанной концепции в Сибири и на Дальнем Востоке, а также Комплексный инвестиционный проект «Енисейская Сибирь», как реальная основа создания инновационных промышленных кластеров, обеспечивающих связанность и конкурентные отношения между участниками кооперационных проектов.
Три кризиса новейшей экономической истории России
Authors: Фомин Д.А.
Published: June 2022

В новейшей экономической истории России выделены три кризиса. Первый из них (1914–1927 гг.) связан с событиями Первой мировой войны, революции и Гражданской войны. В основе второго (1941–1947 гг.) лежала Великая Отечественная война. Третий (современный) начался после распада СССР в конце 1991 г. Все кризисы охарактеризованы с точки зрения глубины падения производства, сокращения основных фондов и нанесённого экономике ущерба. По расчетам автора, третий кризис стал наиболее разрушительным и масштабным в новейшей истории. Анализ современной производственной динамики показал, что после 2008 г. Россия в рамках существующей экономической политики не способна восстановить объем своего докризисного производства и не в состоянии сохранить доставшийся ей с советских времен объем материального потенциала.
Пространственная интеграция экономики: теоретические концепции и проблемы обеспечения на региональном уровне
Authors: Кожевников С.А.
Published: June 2022

В статье на базе критического анализа теоретических концепций обоснованы сущность, «родовые» признаки, предпосылки и условия обеспечения пространственной интеграции экономики регионов. Показано, что интеграция часто трактуется как синоним конвергенции территорий, однако взаимодействие муниципалитетов Республики Карелия и Финляндии обнаруживает иное – она не всегда обеспечивает конвергенцию на практике. Рассматривая интеграцию как процесс, развивающийся во времени и по сферам, с использованием закона единой цены, а также в рамках «потокового» подхода к оценке, были исследованы особенности интеграционных процессов на рынках товаров и факторов производства (труда) северных регионов. Проанализированы институциональные, нормативно-правовые, инфраструктурные аспекты пространственной интеграции, барьеры и проблемы ее обеспечения на внутри- и межрегиональном уровнях. Обоснованы приоритеты государственной политики по обеспечению единства экономического пространства страны.
Демографическая динамика крупнейших городских агломераций России
Authors: Чернышев К.А.
Published: June 2022

В статье рассматривается демографическая ситуация в 18 городских агломерациях, определённых Стратегией пространственного развития РФ на период до 2025 г. в качестве перспективных центров экономического роста РФ. Рассчитаны показатели естественного и миграционного прироста за 2012–2020 гг. Определена роль компонентов демографической динамики в изменении численности населения. Показано значение потоков международной, межрегиональной и внутрирегиональной миграции в формировании миграционного прироста (убыли). Отмечается, что в условиях доминирования агломераций Москвы и Санкт-Петербурга крупнейшие агломерации второго уровня являются «слабым звеном» в иерархии центров расселения и экономической активности.
Развитие медной промышленности России и Монголии: проблема выхода на внешние рынки
Authors: Безруков Л.А. , Фартышев А.Н.
Published: June 2022

На примере медной промышленности рассмотрена проблема конкурентоспособности монгольских и российских (восточносибирских) минерально-сырьевых товаров на внешних рынках. Дан анализ конъюнктуры мирового рынка меди и места на нем Китая, России и Монголии. Представлена сравнительная характеристика разрабатываемых и подготавливаемых к освоению крупных месторождений меди Монголии (Эрдэнэтийн овоо и Оюу-Толгой) и Восточной Сибири России (Быстринское, Удоканское, Ак-Сугское, Кингашское). Обосновано предположение о возможности обострения соперничества между экспортерами медной продукции Монголии и России за внешние рынки сбыта, прежде всего китайский. Проведена оценка транспортно-географического положения месторождений относительно ближайших китайских промышленных центров и морских экспортных портов, показавшая преимущества месторождений Монголии по сравнению с восточносибирскими. С помощью SWOT-анализа подтверждено, что углубление переработки сырья обеспечивает более благоприятные условия выхода медной продукции Восточной Сибири на внешние рынки, в том числе ослабляет риски конкуренции с Монголией.
Headroom-based optimization for placement of distributed generation in a distribution substation
Authors: Nweke John N. , Salau Ayodeji Olalekan , Eya Candidus U.
Published: June 2022

This paper presents a headroom-based optimization for the placement of distributed generation (DG) in a distribution substation. The penetration limits of DGs into the existing distribution substations are often expressed as a function of the feeder’s hosting capacity (headroom). Therefore, it is important to estimate the reliability of the network's operation as well as that of the limits imposed by the power quality standards by evaluating of the hosting capacity (headroom) of the existing distribution feeder substation. This study aims at developing a novel algorithm for positioning a bus with permissible headroom capacity for DG positioning without causing voltage violations but maximizing the active power supply. Since DG increases short-circuit faults, the algorithm is useful for utility companies to select feeder substations that have permissible headroom capacity for DG installation and thus, contributing to reducing high DG penetration in the network. The modeling and optimization were carried out the Power System Software for Engineers (PSS/E) environment using the IEEE 14-bus test system. The results obtained from the case study show that only two (2) feeder substations out of fourteen (14) have the permissible headroom capacity for DG connections.
PERFIL CLÍNICO E EPIDEMIOLÓGICO DE PACIENTES SUBMETIDOS A AMPUTAÇÃO DE MEMBROS INFERIORES
Authors: Rodrigues Alessandra dos Santos de Araújo , Silva Andréa Pereira da , Cardoso Adelzira Rodrigues , Araujo Filho Augusto Cezar Antunes de , Arrais Kamilla Rocha , Silva Juan Victor da , Silva Maiara Soares Gomes da , Magalhães Rosilane de Lima Brito
Published: June 2022

Objetivo:Caracterizar o perfil clínico e epidemiológico dos pacientes submetidos à amputação de membros inferiores em um hospital público do sul do Piauí. Métodos: Estudo retrospectivo, descritivo, com análise documental e abordagem quantitativa. A coleta de dados ocorreu nos meses de julho e agosto de 2021, sendo realizada por meio de um instrumento elaborado pelos pesquisadores. Os dados foram processados pelo o software estatístico Statistical Package for Social Sciences, versão 20.0. Resultados: A amostra foi composta por 70 pacientes com média de idade de 65,6 anos, a maioria do sexo masculino (61,4%), de cor parda (88,6%), casada (48,3%), aposentada (42,9%), advinda de outras cidades do Piauí (87,1%). A maioria dos pacientes (47,1%) apresentava uma comorbidade no momento da amputação, sendo o diabetes mellitus (34,3%) a mais prevalente, seguido de hipertensão arterial sistêmica (12,9%). O diabetes mellitus foi a principal causa de amputação (48,6%), sendo a nível transfemoral (42,9%) a mais predominante. Todos os procedimentos foram realizados em caráter de urgência, e grande parte das internações (94,3%) evoluiu para alta. Conclusão: Os achados demonstram que pessoas com diabetes mellitus, do sexo masculino e idosas foram as que mais se submeteram a amputação, sendo o nível transfemoral o mais realizado
Penggunaan Google Classroom Sebagai Media Pembelajaran Daring Bagi Guru SD Di Kabupaten Inhil
Authors: Ain Siti Quratul , Dafit Febrina
Published: June 2022

Masalah yang dihadapi mitra dalam mengimplementasikan proses belajar mengajar secara daring dimasa pandemic covid adalah kurangnya pemahaman dalam mengelola kelas. Google classroom merupakan salah satu media pembelajaran daring yang dapat digunakan pada masa pandemic covid19. Tujuan kegiatan ini dilakukan adalah untuk memberikan pengetahuan kepada guru dalam mengelola kelas dengan memanfaatkan google classroom sebagai media pembelajaran dan membantu mitra dalam proses pembelajaran secara daring. Metode pelaksanaan kegiatan ini terdiri dari kegiatan ceramah, praktek dan diskusi. Kegiatan pelatihan ini dilakukan pada bulan desember secara daring selama 120 menit. Pelatihan ini diikuti oleh 12 orang guru sekolah dasar SDN 031 Suhada kecamatan Enok Kabupaten Indragiri hilir. Setelah dilakukan pelatihan,  Guru dapat mengelola kelas di google classroom, diantaranya membuat kelas, memasukkan materi pelajaran, membuat kuis dan membuat daftar hadir secara online. Adapun kesulitan guru dalam menggunakan google classroom adalah dalam pembuatan kuis dan dalam membuat daftar hadir. Melalui kegiatan ini, guru dapat mengelola kelas menggunakan google classroom, memudahkan dalam memberikan materi , mempermudah melakukan evaluasi dan penilaian. Serta proses pembelajaran bisa dilakukan kapan dan dimana saja .
Influence of Atmospheric Conditions on Labor Onset: A Single-Center Retrospective Cross-Sectional Study in Japan
Authors: Hosoya Satoshi , Tsujimoto Tetsuro , Oishi Hajime , Sadatsuki Miyuki
Published: June 2022

Background: Although the mechanism underlying labor onset is controversial, there is an empirical finding that bad weather influences it. Previous reports have focused mainly on the relationship between the timing of deliveries and the weather conditions; fewer reports have focused on the timing of labor onset. Thus, we investigated the relationship for identifying atmospheric factors contributing to labor onset. Methods: We conducted a Japanese single-center retrospective cross-sectional study for identifying atmospheric factors contributing to labor onset over 8 years. We gathered daily atmospheric data in Tokyo from the official homepage of the Japan Meteorological Agency; mean barometric pressure, total solar irradiation, mean vapor pressure, and difference between the warmest and coldest temperatures. The percentage of days on which 1 or more laboring woman was hospitalized and the number of laboring women hospitalized per day were evaluated between low and middle/high groups for each atmospheric condition. Results: In total 1178 eligible women, the percentage of days significantly increased on days of low total solar irradiation (low group: 38% vs middle/high group: 31%; p < 0.001). The number of laboring women also significantly increased in such conditions (low group: 0.46 vs middle/high group: 0.38; p < 0.001). There were no significant differences in others. Conclusions: On days of low sunshine, pregnant women are more likely to start laboring. Further investigations will be needed to clarify the relationship between solar irradiation and labor onset.
Primary Ovarian Insufficiency: Time to Diagnosis and a Review of Current Literature
Authors: Minis Evelyn , Pinero Lisa , Bhatt Shweta , O'Besso Valerie , Douglas Nataki C. , Morelli Sara S.
Published: June 2022

Background: Prompt recognition of symptoms and subsequent diagnosis of primary ovarian insufficiency (POI) are critical given its consequences on quality of life and long-term health. Poor access to care in underrepresented minority women and/or low-income populations may contribute to delayed diagnosis. Our group previously demonstrated a dearth of board-certified reproductive endocrinology (RE) physicians providing care for Medicaid patients in New Jersey. Given the adverse effects of prolonged hypoestrogenism, we aimed to evaluate length of time to diagnosis of POI in a low-resource/low-income population presenting to an urban university-based RE clinic, as well as provide a review of the current literature. Methods: This retrospective case series included all new patients seen at the RE clinic at University Hospital in Newark, NJ from June 2014 through June 2018. POI was diagnosed in women with oligo/amenorrhea and menopausal levels of follicle stimulating hormone. The primary outcome was time to diagnosis from onset of symptoms. Results: Of 524 new patients seen, 19 (3.6%) were diagnosed with POI. Median time to diagnosis of POI from onset of symptoms was 48 months. 57.9% of our patients identified as Black and 31.6% as Hispanic. 13/19 (68.4%) reported hypoestrogenic symptoms at time of referral. 21.1% were diagnosed with Turner mosaicism. 14 of 19 patients completed DEXA scan, of which 35.7% were diagnosed with low bone mass or osteoporosis. Of those diagnosed prior to referral to RE (9/19, 47.4%), only 4 had initiated hormone therapy. Conclusions: Our study demonstrates a need for more aggressive evaluation of oligo/amenorrhea in underrepresented minority women. Prolonged time to diagnosis of POI has adverse effects, as reflected by hypoestrogenic symptoms and decreased bone mineral density. Delayed diagnosis and management of POI may be related to health care disparities facing these women and warrants action to improve access to care.
Does Sleep Quality of Pregnant Women Influence Perinatal Outcomes in Poland?
Authors: Smyka Maagdalena , Kosińska-Kaczyńska Katarzyna , Sochacki-Wójcicka Nicole , Zgliczyńska Magdalena , Wielgoś Mirosław
Published: June 2022

Background: To assess sleep quality during the latest pregnancy and to investigate its relationship with perinatal outcomes. Methods: A cross-sectional survey with a self-composed questionnaire was performed. It included the Pittsburgh Sleep Quality Index (PSQI) and the Berlin Questionnaire. Results: 5890 women giving birth maximum one year before completing the survey were included. 87.8% of the respondents were assessed as having poor sleep according to the PSQI. Poor sleep increased the risk of preterm birth (adjusted odds ratio (aOR) 1.54, 95% confidence interval (CI) 1–2.3) and cesarean delivery (aOR 1.2, 95% CI 1–1.4), while it was not related to neonatal birthweight. 5.9% of the respondents were classified as being at a high risk of obstructive sleep apnea according to the Berlin Questionnaire. High risk of obstructive sleep apnea increased the risk of preterm birth (aOR 1.53, 95% CI 1–2.2) and low birth weight infant (aOR 1.64, 95% CI 1.1–2.5). Conclusions: Sleep quality and obstructive sleep apnea risk have an impact on perinatal outcomes.
The Significance of the Ocular Adverse Effect Induced by Systemic Taxane Application
Authors: Ye Ya-Ting , Zhou Zi-Yi , Wen Li-Shi , Sun Yu , Chu Zhao-Jie , Dou Guo-Rui
Published: June 2022

In recent years, in-depth research on anti-tumor therapy has brought the emergence of new active chemotherapeutic agents and combination regimens. However, as one of them, taxane drugs are widely used in clinical practice, but it should be noted that many side reactions caused by their application bring some difficulties to routine management. Among the side reactions related to taxane anti-tumor therapy, ocular adverse reactions are occasionally reported and are not life-threatening but may seriously affect patients’ life quality. Thus, the continuation, reduction and cessation of taxane chemotherapy still need to be further evaluated by ophthalmologists and oncologists once the side effects show up. To prevent ocular side reactions, close attention should be paid to complications during medication. To facilitate the oncology department and ophthalmologists to comprehensively understand the ophthalmic adverse reactions of taxane drugs and their possible mechanisms and improve drug use efficiency, we collected relevant literature and reviewed and provided some suggestions for the monitoring and managing of ophthalmic toxicity.
Molecular Mechanisms of Microbial Extracellular Electron Transfer: The Importance of Multiheme Cytochromes
Authors: Paquete Catarina M. , Morgado Leonor , Salgueiro Carlos A. , Louro Ricardo O.
Published: June 2022

Extracellular electron transfer is a key metabolic process of many organisms that enables them to exchange electrons with extracellular electron donors/acceptors. The discovery of organisms with these abilities and the understanding of their electron transfer processes has become a priority for the scientific and industrial community, given the growing interest on the use of these organisms in sustainable biotechnological processes. For example, in bioelectrochemical systems electrochemical active organisms can exchange electrons with an electrode, allowing the production of energy and added-value compounds, among other processes. In these systems, electrochemical active organisms exchange electrons with an electrode through direct or indirect mechanisms, using, in most cases, multiheme cytochromes. In numerous electroactive organisms, these proteins form a conductive pathway that allows electrons produced from cellular metabolism to be transferred across the cell surface for the reduction of an electrode, or vice-versa. Here, the mechanisms by which the most promising electroactive bacteria perform extracellular electron transfer will be reviewed, emphasizing the proteins involved in these pathways. The ability of some of the organisms to perform bidirectional electron transfer and the pathways used will also be highlighted.
TREM2 coding variants in Slovak Alzheimer's disease patients
Authors: Durmanova Vladimira , Javor Juraj , Parnicka Zuzana , Minarik Gabriel , Ocenasova Agata , Vaseckova Barbora , Kiralyova Iliana , Sutovsky Stanislav , Petrovic Robert , Shawkatova Ivana
Published: June 2022

Background: Triggering receptor expressed on myeloid cells 2 (TREM2) is an important modulator of innate immune responses. In the human brain, TREM2 is primarily expressed on microglia and is involved in cell survival, phagocytosis, and regulation of inflammation. TREM2 dysfunction has been linked to the pathogenesis of various neurodegenerative diseases including Alzheimer’s disease (AD). Rare coding variants of the TREM2 gene have been reported to modulate AD risk in several populations, however, data on their association with susceptibility to AD in the Slovak population have been missing. Methods: We have analyzed 10 non-synonymous coding variants located in TREM2 exon 2 by direct sequencing in 270 late-onset Alzheimer’s disease (LOAD) patients and 331 controls. Results: Four out of 10 TREM2 mutant variants have been identified in the analyzed groups, namely rs75932628 C > T (R47H), rs142232675 C > T (D87N), rs143332484 C > T (R62H), and rs2234253 G > T (T96K). R47H was found only in the AD group, while T96K was present only in the controls. Although no significant association between TREM2 coding variants and LOAD susceptibility has been detected, the observed odds ratio (OR) of 3.69 for R47H carriers suggests an increased risk of LOAD for this variant in the Slovak population. Moreover, we also found a higher OR for the rs143332484-T allele in APOEε4 non-carriers (1.99) when compared to APOEε4 carriers (0.62). Conclusions: Our results suggest an impact of specific TREM2 rare coding variants on AD risk in the Slovak population.
Craniofacial reconstructions in children with craniosynostosis
Authors: Spazzapan Peter , Kocar Miha , Eberlinc Andreja , Haber Barbara , Velnar Tomaz
Published: June 2022

Background: Craniosynostosis is a rare congenital disease of the skull. They arise when one or more cranial sutures ossify prematurely. This causes an obstruction to normal brain growth and leads to specific deformations of the skull, which may result in intracranial hypertension and cognitive delay. Materials and methods: We have retrospectively analysed all children treated at the Unit of paediatric neurosurgery of the University Medical Centre Ljubljana between June 2015 and September 2020. The following items have been recorded: affected suture, underlying syndromic condition, hydrocephalus, Chiari malformation, raised intracranial pressure, age at surgery, surgical technique, need for multiple operations and surgical complications. Results: During the study period, 71 children have been treated for craniosynostosis. The median postoperative follow-up was 31 months. There were: 54.9% sagittal, 25.3% metopic, 14.0% unicoronal, 1.4% bicoronal and 1.4% unilateral lambdoid craniosynostosis. Multiple sutures were affected in 2.8% cases. 7.0% of the cases were syndromic. Overall, 74 surgical procedures have been performed: frontoorbital advancement represented 40.5% of them; biparietal remodelling 32.4%: total cranial vault remodelling 22.9%; posterior distraction 2.7%; posterior expansion 1.3%. Median age at surgery was 12.8 months. Conclusions: The treatment of craniosynostosis is surgical and requires a multidisciplinary approach, with expertise in plastic and reconstructive surgery, maxillofacial surgery and neurosurgery. The aim of surgical treatment is to release the constrictive and deformative effect that the synostosis has on skull growth. This requires a remodelling of the neurocranium and, if necessary, of the viscerocranium. Beyond aesthetic purposes, the primary aim of surgical treatment is to permit a normal development of the brain.
Comparison of Drug-Coated Balloons and Drug-Eluting Stents in Primary Percutaneous Coronary Interventions for ST-Segment Elevated Myocardial Infarction: A Systemic Review and Meta-Analysis
Authors: Su Hu , Li Menghuan , Hao Lijun , Wang Hui
Published: June 2022

Background: The most optimal strategy for ST-segment elevation myocardial infarction (STEMI) between drug-eluting stents (DES) and drug-coated balloons (DEB) is still unknown. This meta-analysis aims to compare the short-term outcomes of both methods in patients with STEMI. Methods: We searched PubMed, Web of Science, EMBASE, and the Cochrane Library Databases for eligible studies with publication data from 2015 to Jan 2022. Four trials with 360 patients were included. The study was conducted by following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements. Results: There were no significant differences in major adverse cardiac events between DCB and DES during 6 to 12 months of follow-up (RR 1.38, 95% CI: 0.65 to 2.93; p = 0.41). Similar risks of myocardial infarction (RR 0.48, 95% CI: 0.11 to 2.11, p = 0.33), all causes of death (RR 1.55, 95% CI: 0.32 to 7.62, p = 0.59), and target lesion revascularization (RR 1.29, 95% CI: 0.55 to 3.04, p = 0.55) were observed. The pooled results indicated that DCB was comparable to DES in terms of late lumen loss with a mean difference (MD) of –0.06 mm with significant heterogeneity (95% CI: –0.25 to 0.13, p = 0.54, I2 = 85%). Subsequent subgroup analysis based on the study design revealed that late lumen loss was significantly lower in the drug-coated balloon group in randomized controlled trials (MD –0.16, 95% CI: –0.26 to –0.05, p = 0.003). Conclusions: Drug-coated balloons were associated with similar risks of MACE compared with drug-eluting stents in the setting of STEMI. However, a larger randomized controlled trial is required to confirm these observations.
Imaging in Percutaneous Coronary Intervention
Authors: Satish Mohan , Roumeliotis Anastasios , Power David , Camaj Anton , Nicolas Johny , Feldman Daniel , Jones Davis , Yasumura Keisuke , Beerkens Frans , Suleman Saman , Dangas George
Published: June 2022

Intracoronary imaging (ICI) use during percutaneous coronary intervention (PCI) has been shown to effectively improve cardiovascular outcomes, particularly for high-risk subgroups. However, data from randomized controlled trials are limited and the overall utilization rate of ICI remains variable between different countries and centers. Potential benefits of ICI include identification of appropriate lesions for PCI, improved characterization of lesions, and optimization of stent placement. Currently available modalities of ICI include intravascular ultrasound, optical coherence tomography and near infrared spectroscopy. Within this review, we summarize the contemporary evidence surrounding ICI and discuss its application in clinical practice.
Antiplatelet Therapy in High-Bleeding Risk Patients Undergoing PCI: Walking a Tightrope
Authors: Jones Davis , Nicolas Johny , Beerkens Frans , Satish Mohan , Feldman Daniel , Cao Davide , Spirito Alessando , Mehran Roxana
Published: June 2022

Historically, prevention from ischemic events with dual antiplatelet therapy (DAPT) post percutaneous coronary intervention (PCI) took precedence over protection from bleeding. However, increasing data suggest that major bleeding complications are as detrimental as ischemic events. Awareness about the prognostic impact of bleeding prompted the search for new strategies aimed at maximizing both ischemic and bleeding protection. This is noteworthy because patients at high bleeding risk (HBR) have generally been underrepresented in clinical trials on DAPT and they often are at increased risk of ischemic events as well. The present review discusses the evidence base for new pharmacotherapeutic strategies to decrease bleeding risk without compromising ischemic protection among HBR patients undergoing PCI, including shortening DAPT duration, early aspirin withdrawal, and P2Y12 inhibitor de-escalation.
A single nucleotide variant on chromosome 17 residing within IKZF3 distinguishes patients with HER2+ breast cancer.
Authors: Mamoor Shahan
Published: June 2022

Molecular subtypes, including the human epidermal growth factor receptor 2-enriched subtype (HER2+), drive patient outcomes in human breast cancer but the biological basis underlying subtype-specific disease is not completely understood (1-4). We mined published microarray data (5, 6) to discover in an unbiased fashion the most distinguishing genetic and transcriptional features of tumors of each breast cancer molecular subtype. We identified a single nucleotide polymorphism, rs9911634, residing within IKZF3, as among the most significant genetic differences in the tumors of patients with HER2+ breast cancer. In a separate cohort of patients with HER2+ subtype breast cancer, we observed transcriptome-wide differential expression of a IKZF3 transcript. Analysis of patient survival data revealed that IKZF3 primary tumor expression was correlated with overall survival in patients with basal-like breast cancer. Sequence variation in the IKZF3 gene may be important in understanding differences in genetic background that favor development of HER2+ subtype human breast cancer.
Factorial of Sum of Two nonnegative Integers is equal to Multiple of the Product of Factorial of the Two Nonnegative Integers
Authors: Annamalai Chinnaraji
Published: June 2022

This paper presents a theorem in factorial functions with the sum of any two nonnegative integers that is equal to multiple of the product of factorial of the same two nonnegative integers.
Tác động của bầu không khí trong siêu thị đến hành vi mua ngẫu hứng của khách hàng trong hệ thống siêu thị Coopmart tại Thành phố Hồ Chí Minh
Authors: Huyen Nguyen Phuoc , Giao Ha Nam Khanh
Published: June 2022

Nghiên cứu kiểm định mức độ ảnh hưởng của các thành phần bầu không khí trong siêu thị đến hành vi mua ngẫu hứng của khách hàng trong hệ thống siêu thị Coopmart tại Thành phố Hồ Chí Minh (TPHCM), bằng việc khảo sát 312 khách hàng. Phương pháp phân tích Cronbach’s Alpha, phân tích EFA cùng với phân tích hồi quy bội được sử dụng với phần mềm SPSS. Kết quả cho thấy mức độ ảnh hưởng của các yếu tố đến hành vi mua ngẫu hứng của khách hàng - theo tầm quan trọng giảm dần: Giác quan, Bố trí trong siêu thị, Người tham khảo, Thiết kế trưng bày và trang trí, Nhân viên. Nghiên cứu đề xuất một số hàm ý quản trị cho các nhà quản lý hệ thống Coopmart chú trọng hơn đến các yếu tố bầu không khí trong siêu thị nhằm tăng cường hành vi mua ngẫu hứng của khách hàng.
Hospitalitas Cara Hidup Gereja Mula-Mula Dan Implikasinya Bagi Gereja Masa Kini Ditinjau Dari Kisah Para Rasul 2: 41-45
Authors: Paillin Wiranto Bongga
Published: June 2022

Hospitalitas Gereja Mula-mula, yang menjadi pertanyaan utama dalam tulisan ini ialah seharusnya gereja masa kini meniru hospitalitas pada gereja mula-mula. Mereka saling membantu dan menopang satu dengan yang lain. Dalam tulisan ini penulis memakai metode kualitatif, pendekatan study pustaka. Jika kita lihat sekarang ini dalam kehidupan gereja masa kini, hospitalitas tidak terjalin dengan baik, seperti halnya dengan hubungan antara anak muda, dengan orang tua. Dimana dalam hal ini anak muda sudah tidak menghargai lagi orang tua. Jika kita melihat kembali gereja mula-mula mereka telah menerapkan ajaran Tuhan Yesus yakni saling tolong menolong, mengunjungi, sungguh-sungguh dalam berdoa, bersekutu dan juga memecahkan roti secara bersama-sama.
Mengulik Business Model Canvas Tokocrypto
Authors: Jonathan Jason
Published: June 2022

Tokocrypto atau PT. Crypto Indonesia Berkat adalah layanan bisnis yang menyediakan website marketplace untuk transaksi berbasis crypto. Tokocrypto merupakanaplikasi exchange cryptocurrency yang didirikan pada tahun 2017, yang mempunyai Headquarter di Jakarta Selatan. Beberapa netizen memilih dan merasa lebih aman dibandingkan exchange lainnya terhadap Tokocrypto karena resmi terdaftar di BadanPengawasan Perdagangan Berjangka Komoditi (BAPPEBTI) dan diawasi oleh Kementerian Perdagangan RI. Juga, company ini didukung dan melakukan partnership dengan Binance Exchange, merupakan salah satu exchange dengan popularitas No.1 berdasarkan data Coinmarketcap.com.
UAS Ilmu Antropologi dan Pendidikan IPS
Authors: Annisa Nur
Published: June 2022

Pandemi Covid-19 mempengaruhi perekonomian secara luar biasa. Tahun lalu seluruh dunia menghadapi penurunan ekonomi dan menyebabkan kontraksi yang sangat dalam karena hampir semua negara melakukan pembatasan mobilitas secara ketat, sehingga sekolah ditutup dan anak-anak belajar dirumah masing-masing banyak orang tua mereka kehilangan pekerjaaan akibah dari covid- 19 sehingga banyak sekali masyarakat menjadi badut jalanan baik anak-anak atau pun orang dewasa. Permasalahan perekonomian di masa pandemi Covid-19 menjadi satu polemik yang berkepanjangan. Hilangnya pekerjaan dan tuntutan pemenuhan kebutuhan harian menjadi fokus permasalahan perekonomian tersebut. Masyarakat dituntut untuk berpikir dan bereaksi terhadap kondisi tersebut untuk bertahan hidup. Hasil penelitian menguraikan bahwa faktor pendorong menjadi badut jalanan adalah tuntutan pemenuhan kebutuhan hidup. Perihal ini bermakna bahwa permasalahan ekonomi menjadi permasalahan utama sehingga pelaku memilih menjadi badut jalanan. Badut jalanan di Banjarmasin menjadi pilihan pekerjaan yang digandrungi oleh masyarakat menengah ke bawah. Dalam mendapatkan pekerjaan ini diperlukan hubungan pertemanan (networking). Di samping itu, diperlukan pembiasaan diri untuk hidup berhemat karena pendapatan tidak pasti setiap harinya.
Visualisasi Business Model Canvas pada Ueno Coffee
Authors: Purwantoro Anggie Shalsabilla Maharani
Published: June 2022

Ueno Coffee adalah bisnis yang bergerak dibidang Food and Beverages (F&B) berupa kedai kopi. Ueno Coffee berdiri sejak tahun 2019 berawal dari daerah Madiun. Ueno Coffee memiliki konsep dan karakter Coffee shop yang berbeda dengan yang lain.
Visualisasi Business Model Canvas pada Wirausaha Mobil Bekas
Authors: Prawatyo Otniel
Published: June 2022

Kewirausahaan Showroom mobil bekas membutuhkan perencanaan dan juga pengaturan segala bentuk kompnen dalam menjalankan bisnis agar bisnis dapat berjalan secara efektif dan optimal
Investigating the Relationship Between Physical Education Teachers' Perceptions, Technological Knowledge and Classroom Management Profiles
Authors: Çar Bekir , Sural Volkan , Güler Hasan
Published: June 2022

Overcoming the technology barrier is critical to integrating technology and education. Emerging and changing technologies are rapidly impacting individuals' daily lives as well as their educational lives. The concept of technostress seems to be associated with technological pedagogical field knowledge and classroom management profiles. This study also aims to determine if there is a relationship between PE and physical education teachers' technostress levels, technological pedagogical knowledge, and classroom management profiles. 275 PE and physical education teachers working in Ankara province participated in the study. Data collection was done using the scale to determine teachers' technostres level, technological-pedagogical knowledge and class management profile. The levels of technostres and technological-pedagogical knowledge did not differ significantly by gender, educational status, sport type, place of graduation, age, professional seniority, and time of technology use of physical education teachers. When examining classroom management profiles, there were differences by gender, educational status, athletic department, and age group, but no significant differences between place of graduation, professional seniority, and time of technology use. When examining the class management profiles by gender variable, it was found that female teachers are on the peripatetic and ignorant profile compared to males, by educational level of graduates and in the scatter profile, those who are in the athletic department in the individual sports do not match those in the team sports department in the profile, and in the age group of 24-34 years old were highly rated by the class management profiles in the 35-44 years old category. As a result, it was found that there is an excellent level of significant relationship between the perception of technostars and class management profiles of physical education teachers, in a negative way, while there is a non-significant relationship between Tpba and technostars, with class management and Tpba being positive.
Keteladanan Kepemimpinan Rasul Paulus & Relevansinya bagi Pemimpin Gereja Pada Masa Kini
Authors: Paillin Wiranto Bongga
Published: June 2022

Pemimpin adalah seseorang yang melaksanakan suatu tugas yang berhubungan dengan proses, tingkah laku atau perilaku baik dalam hubungannya dengan suatu individu maupun suatu kelompok. Dalam hal ini pemimpin memiliki suatu tugas tertentu dimana seorang pemimpin harus memiliki suatu potensi atau kualitas dalam memimpin. Pemimpin gereja dalam melaksanakan tugas-tugas dalam melaksanakan tugas-tugasnya ditengah jemaat khususnya dalam konteks masa kini yang pada umumnya sudah melalui proses pendidikan dimana ia telah mempelajari semua hal yang berhubungan dengan teologi. Keberagaman latar belakang pendidikan teologi tersebut yang memberikan suatu karakter atau ciri khas tersendiri bagi pelayan gereja. Artikel ini disusun bertujuan untuk memberikan pemahaman mengenai Keteladanan kepemimpinan dari Rasul Paulus dan relevansinya bagi pemimpin gereja pada masa kini. Dimana pemimpin pada saat ini sudah banyak yang bisa dikatakan menjauh atau tidak sesuai lagi dengan karakteristik pemimpin yang sesuai dengan perintah Tuhan. Banyak pemimpin gereja yang saat ini sudah berbanding terbalik dari pengertian pemimpin itu sendiri. Dengan pendekatan yang digunakan penulis, merujuk pada kepemimpinan seotang rasul dalam perjanjian baru, dimana tokoh ini yaitu Rasul Paulus yang dapat dijadikan teladan dalam memimpin gereja khususnya pada masa kini.Kata kunci: Kepemimpinan, Pemimpin, Rasul Paulus, Pemimpin Gereja.
Perceptions of Physical, Sexual, and Psychological Violence Stories: A Registered Report
Authors: Delker Brianna C , Michel Paige K , Turner Kit , McLean Kate C.
Published: June 2022

Survivors of sexual violence have shared their stories with the public through social media in growing numbers. Recent research shows that sexual violence (versus other, less stigmatizing trauma) stories are perceived as more difficult to tell, and their storytellers less likeable. This is true even when stories have redemptive endings, contradicting an established U.S. cultural preference for redemptive stories. However, it is unknown if sexual violence perceptions generalize to different types of interpersonal violence (IPV) and if audience perceptions vary across 3 major types of IPV (sexual, physical, psychological). This pre-registered replication and extension study investigates these questions with a vignette-based experimental design modeled after 2 published studies by the first and last authors. Broadly, we hypothesized that cultural invalidation of sexual violence stories would extend to any IPV story (vs. non-IPV traumas such as natural disasters), and that within the realm of IPV, cultural invalidation would be more pronounced for psychological violence stories (vs. sexual/physical). Three samples of U.S. adult participants (N=1,045), 2 Nationally Representative and 1 University-based, were randomly assigned online to read 1 of 12 first-person trauma story vignettes and complete self-report surveys of story and storyteller perceptions in a 6 (trauma story: IPV [k=3], non-IPV [k=3]) x 2 (ending: negative, redemptive) between-subjects design. Support for our hypotheses was mixed. IPV (vs. non-IPV) stories were perceived as more difficult to share (η2p = .068) and their storytellers as having less positive personality traits (η2p = .043), even when stories ended redemptively. However, among the 3 IPV types, psychological violence storytellers were not robustly more stigmatized, and sexual violence stories were recognized as particularly difficult to disclose. IPV survivors face obstacles to telling their stories that may hamper both personal recovery and collective momentum for systemic change.
Perkembangan wakaf di bangladesh dan malaysia
Authors: Julianggara Muh Dwi
Published: June 2022

Perwakafan di Bangladesh: Bangladesh berhasil mengembangkan wakaf tunai dimana wakaf tunai ini berperan sebagai suplemen bagi pendanaan berbagai proyek investasi sosial yang dikelola oleh bank Islam. Wakaf Uang di Bangladesh di populerkan melalui pembentukan Social Investment Bank Limited (SIBL) dan dikemas melalui Sertifikat Wakaf Tunai (Cash Waqf Certificate) yang dipergunakan sebagai suatu instrumen keuangan pada perbankan yang mengelola dana-dana sumbanga
A single nucleotide variant on chromosome 17 residing within PGAP3 distinguishes patients with HER2+ breast cancer.
Authors: Mamoor Shahan
Published: June 2022

Molecular subtypes, including the human epidermal growth factor receptor 2-enriched subtype (HER2+), drive patient outcomes in human breast cancer but the biological basis underlying subtype-specific disease is not completely understood (1-4). We mined published microarray data (5, 6) to discover in an unbiased fashion the most distinguishing genetic and transcriptional features of tumors of each breast cancer molecular subtype. We identified a single nucleotide polymorphism, rs907087, residing within PGAP3, as among the most significant genetic differences in the tumors of patients with HER2+ breast cancer. In a separate cohort of patients with HER2+ subtype breast cancer, we observed transcriptome-wide differential expression of a PGAP3 transcript. Analysis of patient survival data revealed that PGAP3 primary tumor expression was correlated with recurrence-free survival in human breast cancer. Sequence variation in the PGAP3 gene may be important in understanding differences in genetic background that favor development of HER2+ subtype human breast cancer.
Space-time landslide hazard modeling via Ensemble Neural Networks
Authors: Dahal Ashok , Tanyas Hakan , van Westen Cees , van der Meijde Mark , Mai Paul Martin , Huser Raphaël , Lombardo Luigi
Published: June 2022

For decades, a full numerical description of the spatio-temporal dynamics of a landslide could be achieved only via physics-based models. The part of the geomorphology community focusing on data-driven model has instead focused on predicting where landslides may occur via susceptibility models. Moreover, they have estimated when landslides may occur via models that belong to the early-warning-system or to the rainfall-threshold themes. In this context, few published research have explored a joint spatio-temporal model structure. Furthermore, the third element completing the hazard definition, i.e., the landslide size, has hardly ever been modeled over space and time. However, the technological advancements of data-driven models have reached a level of maturity that allows to model all three components (Where, When and Size) mentioned above. This work, takes this direction and proposes for the first time a solution to the assessment of landslide hazard in a given area by jointly modeling landslide occurrences and their associated areal density per mapping unit, in space and time. To achieve this ambitious task, we have used a spatio-temporal landslide database generated for the Nepalese region affected by the Gorkha earthquake on the 25th of April 2015. The model relies on a deep-learning architecture trained using an Ensemble Neural Network, where the landslide occurrences and densities are aggregated over a squared mapping unit of 1 x 1 km and classified/regressed against a nested 30 m lattice. At the nested level, we have expressed predisposing and triggering factors. As for the temporal units, we have used an approximately 6-month resolution depending on the mapped inventory dates. The results are promising as our model performs satisfactorily both in the classification (susceptibility) and regression (density prediction) tasks. We believe that the model we propose brings a level of novelty that has the potential to create a rift with respect to the common susceptibility literature, finally proposing an integrated framework for hazard modeling in a data-driven context.