bluuebunny/crossref_metadata_2025 huggingface dataset:
Facile Synthesis and Enhanced Photocatalytic Properties of La2O3/SrSn(OH)6 Nanorods
Authors: Pei Lizhai , Zhang Yong , Zhuang Lihong , Tao Feihu , Xue Zeyang
Published: July 2022

Background:

The efficient removal of the environmental organic pollutants using the photocatalytic technology catalyzed by the semiconductors has attracted great research interest in recent years. La2O3/SrSn(OH)6 nanorods show enhanced photo-catalytic activity towards crystal violet (CV).

Objective:

The aim is to obtain La2O3/SrSn(OH)6 nanorods by a simple hydrothermal route using lanthanum acetate and SrSn(OH)6 nanorods, and research the photo-catalytic properties for the CV degradation.

Methods:

La2O3/SrSn(OH)6 nanorods were obtained by a hydrothermal route using lanthanum acetate and SrSn(OH)6 nanorods and characterized by X-ray diffraction (XRD), transmission electron microscopy, X-ray photoelectron spectroscopy (XPS), diffuse reflectance spectroscopy (DRS), photoluminescence (PL) and photo-catalytic experiments.

Results:

The composite nanorods are comprised of hexagonal SrSn(OH)6 and cubic La2O3 phases. Some nanoscale particles attach to the surface of the nanorods with the diameter and length of about 100 nm and longer than 1 μm, respectively. La2O3/SrSn(OH)6 nanorods show lower band gap value than that of the SrSn(OH)6 nanorods. The photocatalytic reaction rate constant for the CV degradation using 15wt.%-La2O3/SrSn(OH)6 nanorods is 3 times higher than that of the pure nanorods.

Conclusion:

La2O3/SrSn(OH)6 nanorods possess good reusability and stability for the CV removal. The photo-catalytic activity for the CV removal of the SrSn(OH)6 nanorods can be greatly enhanced by the La2O3.
Patient-Reported Outcomes for the Assessment of Sexual Health Among
Patients Affected by Inflammatory Bowel Disease
Authors: Pugliese Daniela , Parisio Laura , Schepis Tommaso , Privitera Giuseppe , Calvez Valentin , Gasbarrini Antonio , Armuzzi Alessandro
Published: July 2022

Patients affected by inflammatory bowel disease (IBD) frequently report impaired quality of sexual life and complain of sexual dysfunctions. Both disease-specific features and psy-chological factors can be held responsible for these conditions. However, sexuality and all matters relating to sexual health are often wrongfully considered unrelated to IBD and, therefore, over-looked during medical visits. To overcome these difficulties and to best assess patients’ percep-tions about their sexual health status, the use of patient-reported outcomes (PROs) could represent a valid strategy. In real-world studies, several non-IBD specific questionnaires, exploring differ-ent domains of sexuality, have been applied and validated for the IBD population.
This review summarizes the available evidence on sexual health among IBD patients and the data supporting the application of PROs to screen the quality of sexual life, as well as the rate and types of sexual dysfunctions, among IBD patients.
Improved Neural Differentiation of Human-induced Pluripotent Stem Cell
[hiPSCs] on a Novel Polyurethane-based Scaffold Containing Iron
Oxide Nanoparticles [Fe2O3 NPs]
Authors: Hoseinian Monireh Sadat , Poormoghadam Delaram , Kheirollahzadeh Fatemeh , Mojtahedi Arya , Salimi Ali , Halabian Raheleh
Published: July 2022

Background:

Repair of the nervous system in humans has always been complicated and faced
difficulties. Cell transplantation approaches using biocompatible scaffolds might be an attractive therapeutic
strategy for neuronal regeneration.

Objective:

We designed a cell delivery platform based on polyurethane [PU] and modified it with iron
oxide nanoparticles [Fe2O3 NPs] for neural induction of human-induced pluripotent stem cells [hiPSC].
Forskolin, IBMX, and different ratios of FBS were employed to induce neurogenesis of hiPSCs. Neural
differentiations were assessed at the level of genes and proteins.

Methods:

As was shown by MTT colorimetric assay, the proliferation and viability of SNL 76/7 on PU/
Fe2O3 were superior in comparison with pure PU and Fe2O3. hiPSCs cultured with PU/Fe2O3 exhibited
an elevated expression of β3-tubulin, MAP2, NSE, OLIG2, as compared to controls. Furthermore, Acridine
Orange staining assured the survival and viability of hiPSCs after 14 days of differentiation.

Result:

All in all, our findings pointed out the biocompatibility and positive regulatory effect of
PU/Fe2O3 on neural markers.

Conclusion:

We believe this scaffold could be a potential candidate for future nerve differentiation applications.
In silico and In vitro Determination of Antiproliferative Activity of Series N-Pyrrolyl
Hydrazide-Hydrazones and Evaluation of their Effects on Isolated Rat Mycrosomes
and Hepatocytes
Authors: Georgieva Maya , Tzankova Diana , Mateev Emilio , Angelov Borislav , Kondeva-Burdina Magdalena , Momekov Georgi , Tzankova Virginia , Zlatkov Alexander
Published: July 2022

Background:

The significant increase of patients suffering from different types of cancer, guides scientists to take prompt measures in the development of novel and effective antiproliferative agents, where the intercalation of heterocyclic fragment in the designed molecules has proven to be a useful practice.

Objective:

The newly synthesized compounds were obtained from the corresponding 1,4-dicarbonyl derivative through multicomponent reactions to produce biologically active target molecules and assessed by in silico and in vitro assays for their possible antitumor activity.

Methods:

The pharmacological bioassay was conducted in the panel of human tumor cell lines (i) SKW-3 (ACC 53) – human T-cell leukemia and (ii) HL-60 (ACC 3) - human acute myeloid leukemia (AML). The statistical processing of MTT data included the paired Student’s t-test with p ≤ 0.05 set as significance level.

Results:

All evaluated structures displayed higher cytotoxic effect against the acute myeloid leukemia HL-60 with 11o and 11p as the most active compared to the activity against SKW-3 cell line. Throughout the cytotoxicity screening two molecules, 11l and 12o, displayed comparable chemosensitivity on both cell lines. The corresponding hepatotoxicity on isolated rat hepatocytes and microsomes was also established, identifying 11, 12 and 12a as the least toxic and 11x, 11d, 12x and 12d as the most toxic derivatives.

Conclusion:

As most promising compound is underlined ethyl 1-(2-(2-((1-acetyl-1H-indol-3-yl)methylene)hydrazinyl)-2-oxoethyl)-5-(4-bromophenyl)-2-methyl-1H-pyrrole-3-carboxylate (11l) demonstrating highest activity on both evaluated tumor cell lines, decreased hepatotoxicity on all evaluated parameters and docking score of -7.517 kcal/mol.
Psychiatric Manifestations of COVID-19: A Literature Review
Authors: Khatun A. , Tamilanban T. , Chitra V.
Published: July 2022

Background:

COVID19 (coronavirus disease of 2019) occurs due to the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It uses angiotensin-converting enzyme-2 (ACE-2) as its primary receptor to enter the host cell. Recent reports suggest that this pathogen also has a large impact on the CNS alongside other organs. Various inflammatory mediators such as cytokines, chemokines, and numerous metabolites are poorly regulated during infection as well as in several psychiatric diseases, which leads to conditions of hypoxia and cytokine storm. The persistence of COVID-19 infection may also result in aggravation of the already present neuro-psychiatric symptoms in patients.

Methods:

We systematically searched various sources of journals and assessed the varied neurological routes of propagation and pathogenesis of SARS-CoV-2 neurotoxicity like ACE2-mediated neuro-invasion induced hypoxia, and the cytokine storm syndrome. Several case studies were also referred to obtain a better idea of the current mental health scenario as a consequence of infection and inflammation due to SARS-CoV-2.

Conclusion:

Several risk factors for the causation of mental health issues during as well as after the infection include female gender, presence of necrosis, and pain in avascular regions. Most of the psychiatric disorders are directly associated with the socioeconomic and psychosocial changes that occurred as a consequence of the pandemic. These psychiatric manifestations have only started to unravel, which calls for the development of faster means of diagnosis and integrated pharmacological and epidemiological studies to curb the growing rate of neuronal complications as well as mortality.
Emerging Promise of Phytochemicals in Ameliorating Neurological Disorders
Authors: Jayaraman Megala , Dutta Parijat , Krishnan Sabari , Arora Khyati , Sivakumar Diveyaa , Raghavendran Hanumanth Rao Balaji
Published: July 2022

Background:

The field of medicine and synthetic drug development have advanced rapidly over the past few decades. However, research on alternative medicine, such as phytochemicals cannot be ignored. The main reason for prominent curiosity about phytochemicals stems from the belief that the usage of natural compounds are safer and have lesser detrimental side effects.

Objective:

The aim of the present review was to discuss in detail several phytochemicals that have been studied or are being studied in the context of various neurological disorders, including depression, Alzheimer’s disease, Huntington’s disease and even neuroinflammatory disorders, such as encephalitis.

Methods:

The potential roles of phytochemicals in treating or managing symptoms associated with neurological disorders have been included in this article. All data included in this paper have been pooled from various databases, including Google Scholar, PubMed, Science Direct, Springer, and Wiley Online Library.

Results:

Phytochemicals have been widely studied for their therapeutic properties associated with neurological disorders. Using various experimental techniques for both in vivo and in vitro experiments, studies have shown that phytochemicals do have antioxidant, anti-inflammatory and neuroprotective activities, which play major roles in the treatment of neurological diseases.

Conclusion:

Even though there has been compelling evidence of the therapeutic role of phytochemicals, further research is still required to evaluate the safety and efficacy of these medicines. Using previously published papers as the foundation for additional research, such as preclinical studies and clinical trials, phytochemicals can become a safer alternative to synthetic drugs for treating a spectrum of neurological diseases.
Correlations between Insomnia and Sex, Work Experience, Shift and Body
Max Index in Italian Nurses: A Scoping Profile Statement
Authors: Vitale Elsa
Published: July 2022

Aim:

The present study aimed to assess any association existing between insomnia according to sex, work experience, shift and BMI values in Italian nurses.

Method:

An “ad hoc” questionnaire was created and administered online in October 2020. Data collected included: sex, years of work experience, shift work per day, BMI values, and insomnia levels.

Findings:

A total of 341 Italian nurses were enrolled. Of these, 277 (81.23%) were females and n=64 (18.77%) males. No significant differences were assessed between ISI levels and sex, BMI scores, work experience and shift (p=.098; p=.978; p=.561; p=.222, respectively). Significant and inverse correlation was assessed between ISI values and sex (p=.019), BMI values (p=.033). While, no significant correlations were assessed between ISI levels and work experience (p=.805) and shift (p=.962), respectively. However, work experience reported significant correlations between BMI classes (p>.001) and shift (p<.001).

Conclusion:

Data suggested potential health risk factors for the nursing workforce, which was associated with weight gain and developing Metabolic Syndrome. Therefore, the essence of the nursing profession could affect work performance and cause problems in the family and social life, as well as stress, anxiety, depression, fatigue, and irregular sleep patterns.
Factors affecting accountability village fund management
Authors: Diansari Rani Eka , Othman Jaizah Binti , Musah Adiza Alhassan
Published: July 2022

The purpose of this study is to investigate whether or not the accountability of village fund management is affected by factors such as prosocial behaviour, the competency of apparatus, internal control, and external pressure. All of the village fund managers that work for the 13 different village governments located in the Gunungkidul Regency of the Special Region of Yogyakarta make up the sample for this study. Purposive sampling was utilized as the method of choice for data collection in this investigation. According to PERMENDAGRI No. 20 of 2018, the sample for this study consists of 87 people who are authorities in their respective villages and are involved in the management of village money. Quantitative data are used in this investigation for the data type. The research relied on primary data collected through the use of the questionnaire method as its primary source of information. Descriptive statistics, data quality tests, and hypothesis testing are the methods of data analysis that were utilized throughout the course of this study.
Reliability analysis of captive power plant system where the working of standby unit depends on connecting unit
Authors:   Department of Statistics, Punjabi University, Patiala, India, Upasana Sharma , Avtar Singh ,   Department of Statistics, Punjabi University, Patiala, India
Published: July 2022

Captive power plants usually operate parallel to the gridline to overcome the losses associated with power failures. While the connectivity of the power plant and gridline highly depends on the functioning of the electrical breaker. This study reveals the importance of connecting device breakers in a captive power plant to operate the system at full or reduced capacity and safer it from reverse feeding. Using semi-Markov processes reliability model is developed for steam turbine generators interconnected with gridline by an electric breaker. The expressions are formed for reliability measures like mean time to system failure, availability, busy period, and profit using regenerative point techniques. Also, these measures are evaluated numerically using an actual dataset belonging to a captive power plant. Graphical plotting shows a decline in profit with increasing the failure rates of turbine generators, gridline, and working probability of breaker. The revenue per unit uptime of the system is forecasted to get productive profit with different failure rates of the power generator.
Fear of Missing Out (FoMO) and its relation with Depression and Anxiety among University Students
Authors: Sultan Ibrahim Syamsul Anwar , Dahlan Akehsan , Nur Wahida Mahmud Pauzi  , Vetrayan Jayachandran
Published: July 2022

FoMO stands for "Fear of Missing Out", and it was found that greater FoMO reported a high level of depression and anxiety. Results from this cross-sectional study revealed that the majority of the participants had a low level of FoMO and normally scored on depression and anxiety. A significant positive relationship was found between FoMO and psychological variables, and the results also highlighted considerable gender differences in the prevalence of FoMO. Findings may provide insight and further understanding about this phenomenon and how FoMO is not only fulfilling the relatedness needs but also leading to psychological distress.
Keywords: fear of missing out, depression, anxiety, university students
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i20.3358
Urban Park Characteristic as a Key Element for Mental Health Restoration in Malaysia
Authors: Mohd Shobri Nor Izana , Abdul Rahman Norhafizah , Md Saman Nor Hisham , Abraham Juneman
Published: July 2022

A recent study has reported that the Malaysian urban population faces mental health problems due to urbanisation. Nature environment has been expected to give restoration experience among people. Therefore, the objective of this study is to analyse the relationship between park characteristics and mental health restoration in an urban park. Survey questionnaires (n=382) were distributed among urban park users. The analysis was conducted using the Partial Least Square Structural Equation Model. Results show that the Serene and Nature dimensions are the significant factors that give a restorative experience among urban park users. These findings can assist landscape architects in advocating for creating the urban park for mental health restoration.
Keywords: Mental health; restoration experience; perceived sensory dimension, restorative environment
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i20.3377
Cutting Board Hygiene Knowledge, Attitudes and Practices of Food Handlers at Home during Covid19 Pandemic in Selangor
Authors: Mohd Shahid Nadiatul Syima , Abdul Wahab Rabi’atul’ Adawiyah , Rajan Shantakumari , S.M. Nasar-Abbas
Published: July 2022

The microbial quality of cutting boards used in the home kitchen indicates hygiene conditions and a potential source of public health risk. This study aimed to assess the hygiene knowledge, attitudes and practices on cutting boards among food handlers at home during the Covid19 pandemic in Selangor. One hundred home food handlers participated in the online survey using a validated self-administered questionnaire. Overall, findings indicate sufficient hygiene knowledge, attitudes and practices on cutting boards. These findings emphasize the need for educating home food handlers on food hygiene to improve their knowledge, behaviour and practices.
Keywords: Cutting board; hygiene; knowledge, attitudes, and practices (KAP); food handlers
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i20.3437
Accessibility Factor of the Elderly in Achieve Mobility Requirements: Case Study in Kota Kinabalu, Sabah
Authors: Mohd Noor Harifah , Ai Jing Chai , Foo Jurry , Md Ramli Adilah , Sulistyo Joko
Published: July 2022

The Ageing Population is a phenomenon that arises in global countries due to modernization and globalization. The elderly will be marginalized when travelling less due to the inaccessibility to the essential need later in life. This research examines the accessibility factor related to the travel pattern of the elderly. Factor Analysis is used to analyze 29 parameters of the element implemented accessibility towards their living requirements. This study developed four main factors: personal, land use, transportation facilities, and temporal. The research *ndings can assist the government and various agencies in implementing policies and strategies to ful*l the mobility needs of the elderly.
Keywords: Accessibility; the elderly; land use; mobility
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i20.3444
Spatial and Temporal Analysis of Dengue Cases in Peninsular Malaysia: A five-year analysis from 2016 to 2020
Authors: Muhd Nor Khushairie , Che Dom Nazri , Abdullah Samsuri , Precha Nopadol
Published: July 2022

Dengue fever is one of the most common vector-borne diseases spread by Aedes albopictus and Aedes aegypti mosquitos. The regional and temporal trends of dengue cases in East Malaysia are investigated in this study. The study aims to assess the prevalence of dengue cases across 91 districts in Peninsular Malaysia from 2016 to 2020 and, hence, to identify dengue disease's hotspot and cold spot regions. By using ArcGIS, summarised yearly data of dengue cases were analysed. The study results showed that dengue cases mainly occurred in the central part of Peninsular Malaysia.
Keywords: GIS; Vector-borne diseases; Aedes; Spatial epidemiology
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i20.3487
An Analysis of the Impact of COVID-19 Pandemic-related Lockdown Measures on a Large Gastrointestinal Pathology Service in the United States
Authors: NASIR AEJAZ , HOUGH BROOKE , BAFFA CATERINA , KHAZANCHI ARUN , COPPOLA DOMENICO
Published: July 2022

Background/Aim: The coronavirus disease 2019 (COVID-19) pandemic prompted global recommendations to delay non-urgent endoscopic procedures to limit the spread of SARS-COV-2, but such delays had unprecedented impact on the delivery of healthcare. Being a large specialty GI Pathology service, we sought to analyze the effect of the pandemic on the frequency of GI malignancies in our department. Patients and Methods: Based on the electronic search of departmental pathology records, we compared the total numbers of cancer diagnoses (primary and metastatic) from various GI biopsy sites during the 12-month pre- and post-pandemic periods. We summarized patient demographics and analyzed pertinent histopathologic data. Results: For all GI biopsy sites, the number of intramucosal/invasive malignancies reported during the one-year pre-COVID-19 pandemic (pre-COVID) and post-COVID-19 pandemic national lockdown (post-COVID) observation periods were 146 and 218, respectively. Among these, 32 and 70 malignancies were reported for the first quarter (representing the earliest post-lockdown period), 29 and 53 for the second, 41 and 54 for the third, and 44 and 41 for the fourth quarter. During the first two quarters of the post-COVID observation period, the increase in malignant diagnoses was most profound, showing 119% post-COVID increase compared to the pre-COVID levels. Of the two main primary histologic types of large intestinal carcinomas [adenocarcinoma (ADC) and squamous cell carcinoma (SCC)], the most profound post-COVID increase was noted in SCCs (136% vs. 58% for ADCs). Conclusion: Compared to the pre-pandemic baseline, the COVID-19 pandemic caused a major increase in biopsy diagnoses of GI cancers in our department. The most plausible explanations for this trend include inevitable lockdowns to minimize the spread of SAR-COV2, which affected GI endoscopy procedure schedules/re-schedules as well as patient response and adaptation to emerging post-COVID GI healthcare patterns. The COVID-19 pandemic’s long-term impact on the health of GI cancer patients will need to be determined through systematic analyses by multi-disciplinary teams.
Acceptability to and Engagement With a Virtual Sickle Cell Trait Education Program (SCTaware): Single-Center Prospective Study
Authors: Beeman Chase M , Abrams Mary Ann , Zajo Kristin N , Stanek Joseph , O'Brien Sarah H , Chan Peter , Shen Yvette , McCorkle Ben , Johnson Latrice , Chisolm Deena , Barnard-Kirk Toyetta , Mahan John D , Martinez-Mendez Alexandra , Phillips Whitney L , Creary Susan E
Published: July 2022

Background

Public health programs are tasked with educating the community on health topics, but it is unclear whether these programs are acceptable to learners. Currently, these programs are delivered via a variety of platforms including in-person, virtually, and over the telephone. Sickle cell trait (SCT) education for parents of children with this trait is one of many education programs provided by the Ohio Department of Health. The novel SCTaware videoconference education program was developed by a research team after central Ohio’s standard program transitioned from in-person to telephone-only education during the COVID-19 pandemic.

Objective

Our objectives were to investigate the acceptability of the format and engagement with the SCTaware education and assess parental worry about having a child with SCT before and after receiving SCTaware.

Methods

This was a single-center, prospective study of English-speaking parents of children <3 years of age identified to have hemoglobin S trait by newborn screening. Parents who previously received SCT education by telephone, were able to be contacted, and had access to an electronic device capable of videoconferencing were eligible to complete surveys after receiving the virtual SCTaware education program. The SCTaware educator also completed a survey to assess participant engagement. Data were summarized descriptively and a McNemar test was used to compare parental worry before and after receiving SCTaware.

Results

In total, 55 participants completed follow-up surveys after receiving standard SCT telephone education and then completing SCTaware. Most (n=51) participants reported that the SCTaware content and visuals were very easy to understand (n=47) and facilitated conversation with the educator (n=42). All of them said the visuals were respectful and trustworthy, helped them understand content better, and that their questions were addressed. Nearly two-thirds (62%, n=34) reported that the pictures appeared very personal and applied to them. The educator noted most participants (n=45) were engaged and asked questions despite having to manage distractions during their education sessions. Many participants (n=33) reported some level of worry following telephone-only education; this was significantly reduced after receiving SCTaware (P<.001).

Conclusions

Our results suggest that SCTaware is acceptable and engaging to parents. While telephone education may make SCT education more accessible, these findings suggest that many parents experience significant worry about their child with SCT after these sessions. A study to evaluate SCTaware’s effectiveness at closing parents’ SCT knowledge gaps is ongoing.
A systematic review on diverse synthetic route and pharmacological activities of benzimidazole as optimized lead
Authors:   Department Of Pharmaceutical Chemistry, Nargund College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bengaluru-560085 (India), THAPA SHANKAR , NARGUND SACHINDRA L. ,   Department Of Pharmaceutical Chemistry, Nargund College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bengaluru-560085 (India), BIRADAR MAHALAKSHMI SURESHA ,   Department Of Pharmaceutical Chemistry, Nargund College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bengaluru-560085 (India)
Published: July 2022

The aim of this review is to provide the systematic information of synthetic scheme and biological activity of synthesized benzimidazole derivatives. Benzimidazole is widely used lead molecule for the synthesis of various types of pharmacologically active moiety. It is heterocyclic aromatic fused colorless solid having molecular mass of 118.053 g/mol. It is basic in nature and can be served as ligand in coordination chemistry. It is bioactive compound showed various pharmacological activity till now viz. anthelmintics (albendazole, mebendazole), proton pump inhibitors (omeprazole, pantoprazole), antibiotics, antiprotozoal, antifungal, anticancer, anti-viral, anti-oxidant, anti-inflammatory etc. Various synthetic route by various methods is also already reported. Some of them are traditional convenient method, microwave reactor method, solvent free synthesis method, green synthesis method. Due to its wide variety of biological action and the similarity with biomolecule, it is frequently taken as lead for new drug discovery
SRETEN MARIĆ I SUKOB NA KNJIŽEVNOJ LEVICI
Authors: Brebanović Predrag
Published: July 2022

Rad je posvećen Sretenu Mariću (1903–1992), recepciji njegovog opusa i njenim kulturološkim i političkim implikacijama. Na tragu interpretacije Svetozara Petrovića, kao polazište se uzimaju zanemareni i nikada preštampani tekstovi koje je Marić u Zagrebu i Beogradu objavio u periodu od 1936. do 1945. godine. Ti se tekstovi sagledavaju u kontekstu jugoslovenskog sukoba na književnoj levici, da bi – nakon analize njihovog sadržaja i statusa – u završnom segmentu bili izneti sintetički uvidi o razlozima zbog kojih Marić biva čitan kao jedan od najistaknutijih srpskih esejista druge polovine 20. veka.
A Study on changes in trajectory Classification and Prediction Factors of Individual Adolescent Academic Self-Efficacy
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Nam-Youn , Kim Jae-Chul
Published: July 2022

Objectives This study classified the trajectory of changes in academic self-efficacy in adolescence and analyzed the effect of individual psychological characteristics, family factors, and school factors on the potential class type of changes in academic self-efficacy.
Methods In the data of the Daegu Institute of Future Education's Daegu Education Longitudinary Study, some of the data tracked every year for first-year middle school students from 2017 to 2020 were analyzed. Using the latent growth model, the types of changes in academic self-efficacy were classified and multinomial logistic regression analysis was conducted to analyze the effect of the changes in academic self-efficacy on the types of potential classes.
Results As a result, as a result of the study, the trajectory types of changes in academic self-efficacy were classified into three types: ‘Low-level radical upward type’, ‘Medium-level maintenance type’, and ‘High-level gradual upward type’. Academic self-efficacy Factors influencing individual potential classes were more likely to be included in self-recognition among individual psychological characteristics factors, and the better the challenge, the more likely it was to be included in the “Medium-level maintenance type” or “High-level gradual increase type.” The higher the parent's support, the higher the likelihood of being included in the ‘Medium-level maintenance type’ and the ‘High-level gradual increase type’, the better the parent-child relationship, and the higher the parent's support, the higher the likelihood of being included in the ‘High-level gradual increase type’. In terms of school factors, it was confirmed that the better the friend relationship and the higher the teacher's support, the more it was included in the ‘low-level radical rise type’.
Conclusions Through this study, it was confirmed that there was an average change in adolescents' academic self-efficacy for four years from the first year of middle school to the first year of high school, and the difference between individuals was significant. In addition, predictors that are included in each type of ‘Low-level radical rising type’, ‘Medium-level maintenance type’, and ‘High-level gradual rising type’ of academic self-efficacy were identified, and the effects of personal psychological characteristics, family factors, and school factors on adolescents were explored. These findings imply that it is necessary to consider the factors affecting the trajectory of changes in adolescents' academic self-efficacy, and through this, it can be expected that the improvement of adolescents' academic self-efficacy can have a positive effect on academic achievement and school life. It is also meaningful that it can provide implications for school education and the role of teachers to improve adolescents' academic self-efficacy.
Science Teachers' Perception on Teaching Competency to Promote Students' Future Competency
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yu Nan Sook , Kim Jonghee , Park Jee-young
Published: July 2022

Objectives The purpose of this study is to investigate the perception of science teachers on the teaching competency to promote students' future competency.
Methods In order to achieve the purpose of the study, previous studies related to teacher competency were analyzed, and data were collected through e-mail and in-depth interviews with 13 science teachers.
Results The teaching competency required for science teachers in the future educational environment was found to be the teaching competency to promote students' future competency, the ability to use edutech, the individually tailored class competency, and the ability to respond to changes in the educational environment. First, in order to cultivate scientific thinking, scientific inquiry, communication and collaboration skills among students' future competencies, research participants provided opportunities to think and discussed problems together through self-directed inquiry activities. instructional strategies were used to encourage divergent thinking by asking questions, exploring and thinking with students, and encouraging students to seek knowledge. Second, the participants' view of science class influenced not only the selection of teaching/learning strategies, but also the selection and implementation of evaluation methods. Research participants were aware of the practical difficulties of meeting both student-led inquiry activities and knowledge-oriented learning needs, and were proceeding with various solutions through trial and error. Third, teachers felt difficulties in teaching  because they did not experience project research while attending the college of education. In order to understand the changes in the educational environment, class competency, and learner characteristics, it is necessary to provide sufficient opportunities for class demonstrations to pre-service teachers by significantly extending the educational practice period.
Conclusions The study participants emphasized the importance of an open mind to accept changes because the future educational environment is unpredictable. So, subjects for cultivating attitudes to respond to changes in the future educational environment were needed.
A study on communication characteristics experienced by parents in innovation elementary school
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Yang Ja
Published: July 2022

Objectives The purpose of this study is to explore the characteristics of communication experienced by parents in order to find the possibility of rational communication in innovation elementary schools.
Methods This study used a case study method and analyzed how parents of Deulkkot Elementary School, an innovation plus school, experienced communication with teachers. Seven parents were interviewed in-depth with semi-structured questionnaires on experience in innovative schools, communication experience with homeroom teachers, communication experience in school management, general conversation, and school participation consciousness. The collected data were derived from three topics and six categories by applying sequential and cyclical method of Merriam(2009).
Results First, Deulkkot Elementary School strived for reasonable communication between teachers and parents through online and offline information opening and sharing, participation in equal relationships, and bottom-up communication. Second, the teacher tried to communicate with parents with truthfulness through an unauthorized attitude, a mind of consideration and respect, and a reasonable explanation. Third, parents actively supported schools and teachers through expectations for schools, understanding of schools, and mutual exchange activities between parents. The limitations revealed in rational communication were the inconvenience and disappointment that parents felt from some teachers, and internal confrontation and dissatisfaction in parent interaction.
Conclusions In order to realize a democratic autonomous community through rational communication in innovative schools, efforts such as the appropriate size of schools that can communicate, sincere attitudes of teacher, parents' communication skills through parent training, and participation of graduated parents in schools are necessary.
«CASES OF SUDISLAV»: EXPERIENCE OF HYPOTHETICAL RECONSTRUCTION
Authors:   Oryol State Agrarian University named after N.V. Parakhin. Orel. Russia., Mayorov A.A.
Published: July 2022

This work is devoted to the consideration of some details of the historical plot connected with the fate of the younger brother of the famous Prince Yaroslav the Wise - Sudislav Vladimirovich, who spent about 24 years in prison on a knowingly false charge. Traditionally, the details of this historical plot were considered in the context, first of all, of Russian history - the history of Old Rus itself as an administrative-political system and its own as a center for the consolidation of East Slavic ethno-political formations. Rarely have its researchers addressed the issues of the functioning of old Rus statehood in a broad context - as an integral and integral part of a single Eastern and Southern European military-political "symphony". It should be noted that, according to a number of researchers, the first half of the 11th century in Russian history was a time during which the plots of local Russian history were closely intertwined with numerous issues of foreign and domestic political topics - from the Balkan and North Caucasian issues to the Baltic and West Slavic problems. The author of this article considers it possible to pay attention when considering the stated topic to some of its indirect and not always obvious connections and contexts. An analysis and comparison of currently available sources and hypotheses allows us to assume an unobvious influence on the events under consideration of a number of factors - from traditional family inheritance to specific features of foreign policy battles traditional on the East European Plain. The term “hypothetical” accentuated in the title indicates the author’s desire to note the possibility and even some necessity of the emergence of a discussion aimed at increasing the degree of actualization of the plot considered in this article.
REMUNERATION OF OFFICERS OF STATE CUSTOMS SERVICE IN GRAND DUCHY OF LITHUANIA IN LATTER HALF OF XVIII CENTURY
Authors:   Yanka Kupala State University of Grodno (Belarus), Kiturka I.F.
Published: July 2022

The article presents the analysis of the sources of remuneration for customs officers in the Great Duchy of Lithuania in the latter half of the XVIII century. Organizational issues of the State Customs Services in the GDL including the financial provision of customs officers were the responsibility of the Skarbovaya Commission of the GDL. The research leads to the conclusion that the remuneration of the officers was primarily determined based on their position in the Customs hierarchy (counter-registrant, superintendant, intendant, record clerk, chief guard, guard, etc.) and their performance: cost-effectiveness and capacity of customs checkpoints and the workload. Customs officers could be paid not only a fixed amount of a yearly salary but also an additional bonus which was called accidens (from Latin accidens - accidental). An accidens was assigned by the decision of the Skarbovaya Commission and its amount wasn’t regulated by any in-house guidelines. As a rule, it was paid for outstanding day-to-day professional performance and as a reward for honorable service upon retirement. The source of an official pay rise for the performance of Customs officers in the latter half of the XVIII century was a reward for detecting smuggled goods upon customs examination. Its amount initially equated to a quarter of a duty paid by a merchant for transportation of smuggled goods (promyto) and it reached 50% starting from January 1794. For a certain period, large sums of money were accumulated at the customs within the personal responsibility of the head of the Customs as the money from customs duties was transported to the treasury every six months. Such a situation created favourable conditions and opportunities for heads of Customs checkpoints to abuse of official position. Civil servants, having relatively small yearly allowance, often used the collected money for their purposes returning it at the time it was supposed to be transported to the treasury. The article also notes that Customs Service in the GDL in the latter half of the XVIII century presented a special institute in the system of state government and the establishment of a single payment rate for Customs officers of various ranks was definitely an innovation.
Not a Conflict Only: Potential for Digital Interaction between Israel and Palestine
Authors: Babenkova Svetlana Yu. , Mariasis Dmitriy A. , Morozov Vladimir M.
Published: July 2022

The acceleration of digitalization processes, caused, in particular, by the pandemic of the new coronavirus, makes it possible to more seriously consider new technologies as a tool for solving a number of socio-economic problems, both at the local and regional and, more broadly, global levels. The relevance of the study lies in the fact that today Israel, not being an exception, has become a participant in the process of involving digital technologies to solve government problems, and the study of such opportunities can become a new contribution to the solution of the Israeli-Palestinian conflict. The agreements on cooperation between Israel and a number of Arab countries in the Middle East reached in 2020 contribute to increasing the degree of integration of this state into regional processes. The authors of the article set themselves the goal of demonstrating the opportunities that digital technologies open up to ensure interaction between the business communities of Israel and Palestine at the present stage, even in the context of the ongoing conflict. Among the materials, in addition to the collection of scientific classical proven literature of specialists in the Middle East, the authors used scientific and practical developments in the field of economics and crisis management, which made it possible to more accurately assess the situation and obtain reliable results. Among the methods, the authors used the method of decomposition of the Israeli-Palestinian conflict, the allocation of levels of digitalization and the subsequent construction of the concept of the possible use of digital interaction between the two countries. The result of the study was the development of their own multi-level concept for the development of such interaction, based both on their understanding of digital transformation processes and on the specifics of regional development processes. The central element of the concept developed by the authors of the article is the so-called interaction platforms (IP), which, in fact, being modern online platforms, de facto form a virtual space to ensure the interaction of the two communities in the economic, financial, educational, and social spheres. Thus, the article shows that digitalization makes it possible to overcome the existing barriers to economic development, especially for Palestine. It enables the business community of both countries to considerably reduce the significance of the current unfavorable geopolitical situation and intensify the economic component of bilateral relations. Moreover, the mechanisms we propose can operate in the context of an ongoing conflict, which is of paramount importance, since in this case there is a possibility of a gradual improvement in the economic situation in Palestine.
Value Sovereignty in the Era of Global Convergent Media
Authors: Degterev Denis A.
Published: July 2022

Sovereignty in the digital space is a relatively new phenomenon, which is discussed in this paper. It is complex in nature and depends both on the technological base which is used (primarily network equipment, including 5G, etc.), software products and platforms, and on the promoted content. The countries are faced with the difficult task of regulating the activities of global media holdings in order to maintain value-based sovereignty. The author gives a political and economic analysis of value sovereignty, showing the importance of the state as a regulator that allows to eliminate negative informational externalities. Particular attention is paid to the analysis of the international media landscape and the formation of multipolarity in the network space, including the growing phenomenon of technological convergence in the media industry, as well as the positions of individual countries and regions in the global media industry. The corporate structures of the world’s largest media holdings are studied and the increasing degree of diversification of their assets is revealed. The generational differentiation of socialization mechanisms in the post-pandemic era, including the proportion of time devoted to social platforms, traditional media (the case of television), as well as the main ways of accessing the Internet and the penetration of new technologies. The most promising for socialization and fast-growing segments are shown, including Internet TV, virtual reality technologies, video games and cyber-sports. In the final part of the paper the author discusses the main problems and challenges of regulating the national media space in order to ensure value sovereignty in the era of global convergent media.
On the issue of studying the size of dust particles in coal mining areas using the depositing ability of the snow cover
Authors: Sumina Alena V. , Pavlova Ekaterina V. , Kyrova Svetlana A. , Pavlovich Vorozhtsov E.
Published: July 2022

The analysis of the particle size of suspended solids in snow samples from various areas near the coal-mining enterprise “Razrez Arshanovsky” LLC in the Republic of Khakassia. Snow sampling sites of the snow cover were located in the area of the road along which coal is transported, and at a distance of 0,5 km from the village of Arshanovo in accordance with the wind rose. Particle size analysis was performed using a LaskaTD device. It was found that in the samples under study, the main proportion of suspended particles, regardless of the point of study, had sizes from 5 to 20 microns, which numerically amounted from 63.8 to 81,3 % of the total weight of suspended substances. The site located in the western direction at a distance of 0,5 km from the Arshanovo had such low values of suspended solids that it was not possible to determine them using the Laska-TD device. The average particle size, depending on the point of study, had the following values (μm): № 1 - 11,2 ± 0,4; № 2 - 11 ± 1,6; № 3 - 9,3 ± 0,2; № 4 - 7,3 ± 0,9; № 5 - 13,5 ± 0,3; № 6 - 11,5 ± 0,2; № 8 - 11,6 ± 0,3. The obtained results of the study allow to conclude that there is a large amount of fine dust in the snow cover, which can accumulate in the environment and negatively affect its biological component, including humans.