bluuebunny/crossref_metadata_2025 huggingface dataset:
“They're experiencing a different sort of trauma”: Mental Health Effects of Living through the COVID-19 Pandemic Among Primary Educational Settings
Authors: Majnoonian Araz , Duong Dawn , Vo Anh Van , Wijaya Carrissa , Nguyen Megan , Flores Marlene , Omaleki Vinton , Le Tina , Fielding-Miller Rebecca
Published: February 2023

The COVID-19 pandemic has affected the mental health of students and educational staff in all learning environments. We conducted a qualitative study to understand the mental health impacts experienced by students and school staff during virtual, in-person, and hybrid learning throughout the pandemic. We facilitated 15 focus group discussions (FGDs) in English and Spanish with 20 parents and 19 school staff from socially vulnerable communities with comparatively high rates of COVID-19 compared to the rest of San Diego County. We analyzed the data using an iterative process to identify common themes that emerged from FGDs. Participants in FGDs report feeling anxious, overwhelmed, and afraid of learning and working in unsafe environments. Simultaneously, teachers and parents are experiencing feelings of helplessness and burnout from virtual learning. Parents report adverse social, emotional, and behavioral changes in children during the pandemic, regardless of whether they were in virtual or in-person learning. Changes parents noticed include social withdrawal, unwillingness to return to in-person learning, and changes in personality. Virtual and in-person learning during the pandemic has been stressful for people in school communities. The psychological effects participants describe seem to echo classic descriptions of complex trauma, which if left unaddressed, can lead to long-term suffering. As we move into the long-term phase of the COVID-19 response, schools will need to monitor if these behavioral patterns persist and adopt a trauma-informed approach that encompasses the school community as a whole.
Removal performance of dissolved organic matters from municipal secondary effluent by different advanced treatment processes and the following disinfection by-products generation rules
Authors: Li Xingyue , Liu Shiqi , Wang Shiqi , Feng Li , Gao Peng , Liu Yongze , Zhang Liqiu
Published: February 2023

Various advanced treatment processes including ultrafiltration (UF), ozonation, enhanced coagulation, and biological aerated filter (BAF) have been applied to reduce dissolved organic matters (DOMs) from the secondary effluent of municipal wastewater treatment plants (MWTPs). In this study, DOMs were characterized and the relationship between DOMs characteristics and DBPs generation was investigated systematically. Results showed that BAF and ozonation processes could significantly affect DOMs characteristics in the treated effluents and the following DBPs generation. UF and enhanced coagulation reduced the production of DBPs by removing large molecular hydrophobic organics. The removal of low molecule DOMs by BAF resulted in a 67.6% reduction in trihalomethanes (THMs) production. Ozonation could oxide large hydrophobic DOMs into small hydrophilic molecules containing aldehyde and ketone groups, leading to 54% increase of chlorinated aldehydes (CHs) and halogenated ketones (HKs). Humic acid (HA) was the main organics type in DOMs and important precursor for THMs and dichloroacetonitrile (DCAN) formation. The generation of trichloromethane (TCM) showed a significant positive correlation (R2 = 0.987) with the specific ultraviolet absorbance at 254 nm (SUVA). Large molecule hydrophobic DOMs devoted the most to the formation of carbonaceous disinfection by-products (C-DBPs) and \(\text{N}{\text{H}}_{\text{4}}^{\text{+}}\)-N content was an important factor affecting the generation of nitrogenous disinfection by-products (N-DBPs). These results are important for the optimization of advanced treatment process in MWTPs, and controlling DBPs should consider the removal of low MW hydrophobic DOMs and the reduction of SUVA.
Development of an international core outcome set for treatment trials in necrotising enterocolitis – A study protocol
Authors: Klerk Daphne , Varsseveld Otis C van , Offringa Martin , Modi Neena , Lacher Martin , Zani Augusto , Pakarinen Mikko P , Koivusalo Antti , Jester Ingo , Spruce Marie , Derikx Joep PM , Bakx Roel , Ksia Amine , Vermeulen Marijn J , Kooi Elisabeth MW , Hulscher Jan BF
Published: February 2023

Aim: Necrotising Enterocolitis (NEC) is the most lethal disease of the gastrointestinal tract of preterm infants. New and existing management strategies need clinical evaluation. Large heterogeneity exists in the selection, measurement, and reporting of outcome measures in NEC intervention studies. This hampers meta-analyses and the development of evidence-based management guidelines. We aim to develop a Core Outcome Set (COS) for NEC that includes the most relevant outcomes for patients and physicians, from moment of diagnosis into adulthood. This COS is designed for use in NEC treatment trials, in infants with confirmed NEC.
Methods: This study is designed according to COS-STAD (Core Outcome Set-STAndards for Development) recommendations and the COMET (Core Outcome Measures in Effectiveness Trials) Initiative Handbook. We obtained a waiver from the Ethics Review Board and prospectively registered this study with COMET (Study 1920). We will approach 125 clinicians and/or researchers from low-middle and high-income countries based on their scientific output (using SCIVAL, a bibliometric tool). Patients and parents will be approached through local patient organisations. Participants will be separated into three panels, to assess differences in priorities between former patients and parents (1. lay panel), clinicians and researchers involved in the neonatal period (2. neonatal panel) and after the neonatal period (3. post-neonatal panel). They will be presented with outcomes currently used in NEC research, identified through a systematic review, in a Delphi process. Eligible outcome domains are also identified from the patients and parents’ perspectives. Using a consensus process, including three online Delphi rounds and a final face-to-face consensus meeting, the COS will be finalized and include outcomes deemed essential to all stakeholders: health care professionals, parents and patients’ representatives. The final COS will be reported in accordance with the COS-Standards for reporting (COS-STAR) statement.
Conclusions: Development of an international COS will help to improve homogeneity of outcome measure reporting in NEC, will enable adequate and efficient comparison of treatment strategies, and help the interpretation and implementation of clinical trial results. This will contribute to high-quality evidence regarding the best treatment strategy for NEC in preterm infants.
Establishment and characterization of the first Cuvier's Beaked whale (Ziphius cavirostris) in vitro model based on the muscle-derived cell line
Authors: Peruffo Antonella , Bassan Irene , Corain Livio , Otero-Sabio Cristina , Giacomello Marta , Centelleghe Cinzia
Published: February 2023

In this study we present for the first time, an in vitro model based on a muscle-derived cell line from a Cuvier's Beaked whale male. This cell line represents a new opportunity to testing toxic effects of water pollutants, in Cuvier's Beaked living cells.
Cell line characterization included karyotyping, assessment of growth rate and ultrastructural analysis. The population doubling time was determined to be ~54 h. The karyotype analysis revealed the presence chromosomes pairs 2n = 42. Immunohistochemical studies showed that cells express actin, vimentin and desmin. This cell line, represents a new opportunity to understand the physiological of the Ziphius cells and provide a novel in vitromodel to investigate alterations due to waters pollutants.
Clinical characteristics and homology analysis of Staphylococcus aureus from would infection at a tertiary hospital in southern Zhejiang, China
Authors: Jin Xiaoya , Zhang Jiarong , Tu Jingjing , Chen Yongpin
Published: February 2023

Objective
Staphylococcus aureus (S. aureus), especially Methicillin resistant S. aureus (MRSA), has been disseminated across communities and hospitals, associated with severe infections and organ failure. In order to understand the clinical epidemiological characteristics of S. aureus stains in the first affiliated Hospital of Wenzhou Medical University in 2018, the prevalence and the drug resistance of S. aureus stains were investigated, for improving the clinical effective prevention and control of S. aureus infection.
Methods
A total of 105 S. aureus isolates were separated from wound infection of inpatients in the first affiliated Hospital of Wenzhou Medical University in 2018, and the department distributions and drug resistance of the isolates were analyzed. The genotyping homology analysis was conducted through the random amplified polymorphic DNA typing (RAPD-PCR) coupled with NTSYS cluster analysis.
Results
Among the 105 strains of S. aureus, 31 isolates were MRSA. The prevalence of MRSA among inpatients in the departments of burn, trauma, orthopedics, nephrology and neurosurgery were 35.48%, 19.35%, 9.68%, 6.45%, and 29.03%, respectively. Among the 105 strains, 35.24% strains were the hospital-acquired infections (HAI) and 64.76% strains were community-acquired infections (CAI). Random amplified polymorphic DNA genotyping of the 105 S. aureus strains showed seventeen different groups, most of which were type I, type VII, type IX, and type VII, the others were scattered.
Conclusion
The clinical characteristics of the 105 S. aureus between MRSA and MSSA strains differed significantly in the first affiliated Hospital of Wenzhou Medical University in 2018. In order to curb the nosocomial infection and protect the susceptible populations, it is vital for us to the monitor, prevention and control for the S. aureus infection and transmission in the nosocomial settings. The observations from the study would improve our management of disinfection and sterilization measures, and provide guidance for clinical medication.
Robotic Pendant Drop: Containerless Liquid for μs-resolved, AI-executable XPCS
Authors: Ozgulbas Doga , Jensen Don , Irvin Michael , Nakaye Yasukazu , Dufresne Eric , Seifert Soenke , Babnigg Gyorgy , Ramanathan Arvind , Zhang Qingteng
Published: February 2023

X-ray Photon Correlation Spectroscopy (XPCS) probes the spontaneous fluctuation in spatial configurations of mixed phases, which can significantly impact the material properties of complex fluid. Tailored material design, however, requires navigation through massive multi-dimensional parameter space which is beyond the bandwidth of current XPCS beamline infrastructure. Using 3.7 μs-resolved XPCS, we demonstrate that Brownian dynamics of silica colloidal nanoparticles in a shielded pendant drop suspended from an electronic pipette is consistent with a sealed capillary, validating the use of pendant drop for automated XPCS measurement. Furthermore, the electronic pipette can be mounted on a robotic arm to access different stock solutions and create samples with highly-repeatable and precisely-controlled composition profiles (Video S2). This closed-loop, AI-executable experimental protocol is the first step towards autonomous material discovery and is applicable for not only XPCS, but also other high-throughput light and x-ray scattering techniques for multimodal, collaborative material characterization.
Attitudes of Physiotherapy Students Towards Playing Physical Activity Games
Authors: KARAALI Hayriye KUL , ozcan ozlem
Published: February 2023

Background
Physiotherapists show a positive attitude towards playing games in order to be a role model for pediatric patients and increase the success of therapy. The aim of study is to evaluate the attitudes of students in Physiotherapy and Rehabilitation department towards playing games that contain physical activity.
Methods
The sociodemographic data, students’ regular physical activity habits as well as their computer game playing status and duration were examined. “Attitudes of 18–22 Age Adults for Playing Games That Contain Physical Activity” scale was used for assessing game proneness.
Results
A total of 268 students participated in the study. Among the game proneness scale sub-sections, while the highest score was obtained in the Social Adjustment, the lowest scores were obtained in the "Desire to Play Game" and "To take pleasure from playing game" sub-sections. Males scored higher in “Risk Taking and “to take pleasure from playing game” in comparison with the female students. There was a statistically significant difference between physical activity habits and Game Compassion, Risk Taking, Social Adjustment and to take pleasure from playing game scores.
Conclusion
The present study suggest that monitoring female and non-physical students during undergraduate education might be beneficial for evaluating their attitude towards playing games.
Examining the association between functional social support, marital status, and memory: A systematic review
Authors: Haghighi Paniz , Oremus Mark
Published: February 2023

Background: Functional social support (FSS) has been shown to be positively associated with better cognitive function, especially memory, in cross-sectional and longitudinal studies. To better understand this complex association, researchers should consider the impact of additional factors that affect both FSS and memory. Therefore, we conducted a systematic review to examine whether one such factor, marital status or related variables (e.g., FSS from spouses compared to FSS from relatives or friends), affects (e.g., confounds or modifies) the association between FSS and memory in middle-aged and older adults.
Methods: We searched PubMed, PsycINFO, and Scopus from database inception to June 2022. Eligible articles examined the association between FSS and memory, and included marital status or related variables in the analysis. Data were synthesized narratively using the Synthesis without meta-analysis (SWiM) guidelines and risk of bias was assessed using the Newcastle-Ottawa Scale (NOS).
Results: Four articles were included in the narrative synthesis. All four articles had a low risk of bias. Overall findings suggested some positive associations between FSS from a spouse/partner and memory; however, effect sizes were small and similar to other sources of support, including children, relatives, and friends.
Conclusions: Our review is the first attempt to synthesize the literature on this topic. Despite theoretical support for examining the impact of marital status or related variables on the association between FSS and memory, published studies explored this issue secondarily to other research questions.
Maternal pregnancy-related anxiety and offspring physical growth in childhood: the Ma’anshan birth cohort study
Authors: Zhou Jixing , Zhang Shanshan , Teng Yuzhu , Lu Jingru , Guo Yufan , Yan Shuangqin , Tao Fangbiao , Huang Kun
Published: February 2023

Background: Epidemiological studies have identified maternal antenatal anxiety and adverse birth outcomes, but absence of epidemiological studies has examined the relationship with long term physical growth in children.
Methods: 3,154 mother-child pairs were included based the Ma’anshan birth cohort study. Maternal prenatal anxiety was obtained by administering a questionnaire using the pregnancy-related anxiety questionnaire (PRAQ) scale during the 1st, 2nd and 3rd trimester. Body fat (BF) and body mass index (BMI) were collected on children from birth to 72 months. Group-based trajectory models were applied to fit the different trajectories of BMI and BF.
Results: Maternal anxiety in the 2nd (OR = 0.81; 95% CI: 0.68 to 0.98) and 3rd (OR = 0.82; 95% CI: 0.68 to 0.98) trimester was associated with a decreased risk of RWG in the first year of life. Children aged at 48 to72 months of mothers with anxiety in the 3rd trimester had lower BMI (β = -0.145; 95% CI, -0.279 to -0.011) and BF (β = -0.194; 95% CI, -0.340 to -0.048), and these children were less likely to develop a very high BMI trajectory (OR = 0.59; 95% CI: 0.37 to 0.93), and a high BF trajectory (OR = 0.71; 95% CI: 0.52 to 0.98). A similar association was found between maternal anxiety simultaneously in the 2nd and 3rd trimesters and child physical growth.
Conclusions: Maternal prenatal anxiety in the 2nd and 3rd trimester may decrease weight status in preschool-aged children, which may be related to reduced weight gain in infancy resulting in.
Genome-wide association mapping of resistance to the foliar diseases septoria nodorum blotch and tan spot in a global winter wheat collection
Authors: Haugrud Amanda R. Peters , Shi Gongjun , Seneviratne Sudeshi , Running Katherine L.D. , Zhang Zengcui , Singh Gurminder , Szabo-Hever Agnes , Acharya Krishna , Friesen Timothy L. , Liu Zhaohui , Faris Justin D.
Published: February 2023

Septoria nodorum blotch (SNB) and tan spot, caused by the necrotrophic fungal pathogens Parastagonospora nodorum and Pyrenophora tritici-repentis, respectively, often occur together as a leaf spotting disease complex on wheat (Triticum aestivum L.). Both pathogens produce necrotrophic effectors (NEs) that contribute to the development of disease. Here, genome-wide association analysis of a diverse panel of 264 winter wheat lines revealed novel loci on chromosomes 5A and 5B associated with sensitivity to the NEs SnTox3 and SnTox5 in addition to the known sensitivity genes for NEs Ptr/SnToxA, SnTox1, SnTox3, and SnTox5. Sensitivity loci for SnTox267 and Ptr ToxB were not detected. Evaluation of the panel with five P. nodorum isolates for SNB development indicated the Snn3-SnTox3 and Tsn1-SnToxA interactions played significant roles in disease development along with additional QTL on chromosomes 2A and 2D, which may correspond to the Snn7-SnTox267 interaction. For tan spot, the Tsc1-Ptr ToxC interaction was associated with disease caused by two isolates, and a novel QTL on chromosome 7D was associated with a third isolate. The Tsn1-ToxA interaction was associated with SNB but not tan spot. Therefore some, but not all, of the previously characterized host gene-NE interactions in these pathosystems play significant roles in disease development in winter wheat. Based on these results, breeders should prioritize the selection of resistance alleles at the Tsc1, Tsn1, Snn3, and Snn7 loci as well as the 2A and 7D QTL to obtain good levels of resistance to SNB and tan spot in winter wheat.
Etiological analysis of patients with sudden sensorineural hearing loss: a prospective case-control study
Authors: Xie Wen , Karpeta Niki , Tong Busheng , Liu Jiali , Peng Haisen , Li Chunhua , Hellstrom Sten , Liu Yuehui , Duan Maoli
Published: February 2023

Sudden sensorineural hearing loss (SSNHL) is a multifactorial emergency disease. Until now, the etiology of SSNHL is still unknown. Previous studies regarding the etiology of SSNHL are clinical studies depending on clinical data collection and analysis. Due to the insufficient sample size or various selective bias in clinical studies, the results of these studies may be inaccurate. This prospective case-control study aimed at exploring the possible etiology and risk factors of SSNHL. We enrolled 255 SSNHL patients and 255 sex-, age- and residence- matched non-SSNHL subjects in the control group. Our study shows that there was no significant difference in the prevalence of comorbidities including hypertension and diabetes, as well as the incidence of smoking and drinking habits between the case and control groups (P > 0.05). In addition, the peripheral blood white blood cell count, neutrophil count, platelet-to-lymphocyte ratio (PLR) and fibrinogen level of the case group were significantly higher than those in the control group (P < 0.05). These findings suggest smoking, drinking, hypertension and diabetes may not be related to the onset of SSNHL. However, hypercoagulable state and inner ear vascular microthrombosis related to an elevated fibrinogen level might be the risk factors of the disease. In addition, inflammation play an important role of SSNHL onset. Trial Registration Chinese Clinical Trial Registry. Registration number: ChiCTR2100048991
Fine root turnover and longevity and their responses to nitrogen fertilization of nitrogen-fixing and non-nitrogen-fixing tree species
Authors: Fan Jie , Song Lihao , xu Lihua , Zeng huihui , Liu Licheng , Zhao Zeyao , Chen Tong , Fang Yanni , Mei Li
Published: February 2023

Background and aims
Fine root longevity and turnover respond to changes in soil nitrogen (N) determine plants’ performance at elevated N-level under global N-deposition. This study was conducted to understand the fine root dynamics of N-fixing and non-N-fixing tree species at elevated N-level by N fertilization.
Methods
To determine fine root dynamics (biomass, length density, longevity, and turnover rate) under N-fertilization, a three-year fertilization experiment at 150 g CO(NH2)2. m− 2 year− 1 was conducted for two N-fixing species and two non-N-fixing tree species.
Results
Fine root biomass of the two N-fixing tree species was lower than that of non-N-fixing tree species. N-fertilization decreased root length density, root surface area, and root volume of all tree species. The fine root turnover rate of N-fixing trees was higher but root longevity was lower than that of non-N-fixing species. For all four species, N fertilization decreased fine root turnover rate but increased fine root longevity. Moreover, both the root turnover rate and root longevity of the two N-fixing tree species were more sensitive than the two non-N-fixing tree species to N fertilization. The proportion of long-lived roots of non-N-fixing tree species was higher than that of N-fixing tree species.
Conclusion
Fine roots of N-fixing tree species have shorter longevity and faster turnover rate than that of non-N-fixing tree species. The fine root longevity and turnover of N-fixing tree species were more sensitive to elevated N-level than that of non-N-fixing species at elevated N-level, they have different response strategies to the increase of soil N.
Relationship between alexithymia, loneliness, resilience and non- suicidal self-injury in adolescents with depression: a multi-center study
Authors: zhang bing , chen yang , fu wenxian , jiang cheng , Zhou Yongjie , He Kongliang
Published: February 2023

Objective
Non-suicidal self-injury (NSSI) behaviors are prevalent in adolescents and have adverse effects on physical and mental health. However, little is known about the relationship between NSSI and alexithymia, or the underlying mechanisms that could explain this relationship. This study aimed to elucidate the current status of NSSI in adolescent depression, and analyze the relationship between alexithymia, loneliness, resilience, and adolescent depression with NSSI, so as to provide a theoretical basis for psychotherapeutic interventions.
Method
The study sample involved inpatients and outpatients from 12 hospitals across China and adolescents with depression who met the DSM-5 diagnostic criteria for depression episode. The following scales were used: The Functional Assessment of Self-Mutilation, Toronto Alexithymia Scale, UCLA Loneliness Scale, and Connor Davidson Resilience Scale.
Results
The detection rate of NSSI in adolescents with depression from 2021.01.01-2022.01.01 was 76.06% (1782/2343). Spearman's correlation analysis revealed a significant correlation between alexithymia, loneliness, resilience and NSSI in depressed adolescents, the results of the independent samples t-test showed that the differences between the two groups for each factor were statistically significant. Binary logistic regression results showed that alexithymia (B = 0.023, p = 0.003, OR = 1.023, 95% CI: 1.008–1.038) and depression (B = 0.045, p < 0.001, OR = 1.046, 95% CI: 1.026–1.066) are risk factors for NSSI, resilience (B = − 0.052, p < 0.001, OR = 0.949, 95% CI: 0.935 − 0.964) is a protective factor for NSSI. Alexithymia directly predicted NSSI and also indirectly influenced NSSI through the mediated effect of resilience. Loneliness moderates the first half of the path of this mediated model.
Conclusion
The data from this study provide evidence for the mediating effect of resilience between alexithymia and NSSI, as well as evidence that loneliness can moderate the first segment of the pathway in this moderated mediation model. We discuss perspectives for future research and interventions based on the findings of the study.
Overexpression of Fatty Acid Synthase Attenuates Bleomycin Induced Lung Fibrosis by restoring mitochondrial dysfunction in mice
Authors: Shin Hyesun , Park Shinhee , Hong Ji su , Baek Ae-Rin , Lee Junehyuk , Kim Do-Jin , Jang An-Soo , Chin Su Sie , Jung Sung Hwan , Park Sung-Woo
Published: February 2023

Proper lipid metabolism is crucial to maintain alveolar epithelial cell (AEC) function, and excessive AEC death plays a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The mRNA expression of fatty acid synthase (FASN), a key enzyme in the production of palmitate and other fatty acids, is downregulated in the lungs of IPF patients. However, the precise role of FASN in IPF and its mechanism of action remain unclear. In this study, we showed that FASN expression is significantly reduced in the lungs of IPF patients and bleomycin (BLM)-treated mice. Overexpression of FASN significantly inhibited BLM-induced AEC death, which was significantly potentiated by FASN knockdown. Moreover, FASN overexpression reduced BLM-induced loss of mitochondrial membrane potential and the production of mitochondrial reactive oxygen species (ROS). Oleic acid, a fatty acid component increased by FASN overexpression, inhibited BLM-induced cell death in primary murine AECs. FASN transgenic mice exposed to BLM exhibited attenuated lung inflammation and collagen deposition compared to controls. Our findings suggest that defects in FASN production may be associated with the pathogenesis of IPF, especially mitochondrial dysfunction, and augmentation of FASN in the lung may have therapeutic potential in preventing lung fibrosis.
PhD holders’ working conditions and job satisfaction in Spain: A cross-sector comparison
Authors: Sala-Bubaré Anna , Garcia-Morante Marina , Castelló Montserrat , Weise Crista
Published: February 2023

The present study aimed to compare three job sectors regarding PhD holders’ current working conditions and satisfaction, and whether their working conditions changed after they completed the PhD. We analysed the responses gathered in the survey on the employability of PhD graduates carried out in 2020 by the Catalan University Quality Assurance Agency, AQU Catalunya. Participants were 1,798 PhD holders from all disciplines who graduated between 2014 and 2016 and worked across three job sectors: universities, research institutes and outside academia. Our results offer clear evidence that the working conditions were better for PhD holders working outside academia in terms of the type of contract, working hours and salary, although the connection between their doctoral studies and work is particularly weak. However, we did not find differences in satisfaction with the job content and overall job satisfaction among the three sectors. We also found a clear mismatch between the degree required for the job and the level of responsibilities, not only for PhD holders working beyond academia but also, to a lesser extent, for those working at universities and research institutes. This study contributes to the understanding of academic and non-academic trajectories and points out several gaps and lines for future research and doctoral education.
Heavy quasiparticles and cascades without symmetry breaking in twisted bilayer graphene
Authors: Datta Anushree , Calderon Maria Jose , Camjayi Alberto , Bascones Elena
Published: February 2023

Among the variety of correlated states exhibited by twisted bilayer graphene (TBG), the cascades in the spectroscopic properties and in the compressibility happen in a larger energy, twist angle and temperature range in comparison to other effects, pointing to a hierarchy of phenomena. Using Dynamical Mean Field Theory + Hartree calculations, we show that the spectral weight reorganization associated to the formation of local moments and heavy quasiparticles, and not a symmetry breaking process, is responsible for the cascade phenonema. Due to the fragile topology of TBG, a strong momentum differentiation is found in the incoherent spectral weight. The phenomena reproduced here include the cascade flow of spectral weight, the oscillations of the remote band energies and the asymmetric jumps of the inverse compressibility
Application of wearable devices based on deep learning algorithm in rope skipping data monitoring
Authors: Yongmao Zhang , Yuxin Liu
Published: February 2023

At present, wearable devices have some problems, such as poor adaptability to human motion behavior, and the recognition accuracy required for different wearers cannot be achieved. Based on the principle of deep learning algorithm, this paper realizes the development of intelligent rope skipping movement data monitoring system. Through the universal human body analysis model, the attention mechanism is introduced and embedded into the decoding network. The data set of rope skipping is classified by multiple labels, and the convolution of spatial graph is constructed, which is extended to the time series dynamics of moving human skeleton data. Aiming at the problem of complex information data in the process of moving human body recognition, we use pose estimation to calculate the key points of moving human body, extract the dynamic structure information of human skeleton sequence. Due to the problems of line of sight occlusion in the process of moving human target tracking, a target tracking algorithm based on multi domain convolution neural network is adopted to improve the feature extraction ability of the algorithm by segmenting the target to be tracked and identifying the area around the target. The data set of rope skipping is collected by wearable sensors, and the difference in the numerical range may be large, so the data is normalized. Finally, through the loss function, the fitting effect of neural network can be evaluated, and the gradient optimization model parameters can be calculated, and coping with different data changes. Through the final system performance test, it is verified that the accuracy rate of the system designed in this paper is above 90%, which can effectively monitor the data of skipping rope and be used in the actual operation of skipping rope.
Purification and Characterization of a Glucose tolerant β-Glucosidase from a Newly Isolated Neofusicoccum Parvum strain F7: Production Optimization using Plackett Burman and Box Behnken
Authors: Singh Nivisti , Sithole Bruce , Kumar Ajit , Govinden Roshini
Published: February 2023

Endoglucanases, exoglucanases and β-glucosidases act synergistically to hydrolyse cellulose into glucose monomers. Thus, this study aimed to improve production of a β-glucosidase from a newly isolated Neofusicoccum parvum strain F7 by optimizing the culture conditions and medium components using Plackett-Burman Design (PBD) and Box Behnken Design (BBD). β-Glucosidase production was significantly enhanced (p-value≤0.05) by 1.5-fold to 2.5 U/ml by BBD as compared to the preliminary one variable at a time (OVAT) experiments of (1.6 U/ml). The optimal conditions for enzyme production by BBD were 12 days of fermentation at 20°C, 175 rpm, 0.5% glycerol and 1.5% casein in 50 mM sodium phosphate (pH 6.0) buffer. Three β-glucosidase isoforms referred to as Bgl1, Bgl2, Bgl3 were purified and characterized from the optimized crude extract displaying IC50 values of 2.6, 22.6 and 319.5 mM for glucose, respectively. Bgl3 with a molecular weight of approximately 65 kDa displayed the highest tolerance to glucose among the isoforms. The optimum activity and stability for Bgl3 was observed at pH 4.0 in 50 mM sodium acetate buffer with 80% β-glucosidase residual activity retained for three hours. This isoform also retained 60% residual activity at 65°C for one hour which was then reduced to 40 % which remained stable for another 90 minutes. The β-Glucosidase activity of Bgl3 was not enhanced after the addition of metal ions in assay buffers. The Km and vmax for 4-nitrophenyl-β-D-glucopyranoside were found to be 1.18 mM and 28.08 µmol/min, respectively indicating high affinity to the substrate. The ability to withstand the presence of glucose in conjunction with its thermophilic nature indicates promise for the enzyme in industrial application.
Effects of family function, depression, and self-perceived burden on loneliness in patients with type 2 diabetes mellitus: A serial multiple mediation model
Authors: Zhang Yu , Li Xiangning , Bi Yaxin , Kan Yinshi , Liu Hongyuan , Liu Lin , Zou Yan , Zhang Ning , Fang Li , Gong Weijuan
Published: February 2023

Background
Type 2 Diabetes mellitus (T2DM) has become a major lifestyle disease endangering human health worldwide. Patients with T2DM face varying degrees of loneliness, which adversely affects their family and the larger society. This study investigates the serial multiple mediating roles of depression and self-perceived burden between family function and loneliness in the T2DM population of China.
Methods
In total, 260 T2DM patients were included. They rated themselves based on UCLA Loneliness Scale, Self-Rating Depression Scale, Self-Rating Anxiety Scale, Family Care Index, and Self-Perceived Burden Scale. Pearson and Spearman correlation analyses were conducted to clarify the association among variables. The SPSS macro-PROCESS program was used for a series of multiple mediation analyses.
Results
Family function, depression, self-perceived burden, and loneliness were significantly correlated (P < 0.01). Family function not only has a direct negative impact (effect = -2.809; SE = 0.213; 95%CI: LL = -3.228, UL = -2.390) on loneliness, but also has an indirect impact on loneliness through the independent mediating role of depression (effect = -0.862; SE = 0.165; 95%CI: LL = -1.202, UL = -0.567) and self-perceived burden (effect = -0.288; SE = 0.107; 95%CI: LL = -0.525, UL = -0.114) and the chain mediating role of depression and self-perceived burden (effect = -0.202; SE = 0.066; 95%CI: LL = -0.342, UL = -0.088).
Conclusions
Diversified interventions aimed at improving family function of T2DM patients would help in reducing the level of depression and self-perceived burden, and ultimately reducing loneliness.
Characteristics of falls among older hip fracture patients from six Chinese hospitals: a post- hoc analysis
Authors: Peng Junyi , Ye Pengpeng , Zhang Jing , Zhang Xinyi , Peng Ke , He Jiusheng , Wen Liangyuan , Wang Xianhai , Shi Zongxin , Hu Sanbao , Sun Fengpo , Gong Zishun , Sun Mingyao , Liu Tingzhuo , Liu Xinyan , Ma Ruofei , Zhu Shiwen , Wu Xinbao , Ivers Rebecca , Yang Minghui , Tian Maoyi
Published: February 2023

Background
There is well-established evidence to understand the characteristics of falls among the older patients with hip fracture in many countries, but very little knowledge existed in China. This study described the characteristics of falls in older patients with hip fractures from six Chinese hospitals.
Methods
This cross-sectional study is a post-hoc analysis of a recently completed trial. Eligible patients were aged 65 years and older, with confirmed hip fractures due to falls, and were admitted to the hospital within 21 days of the fracture. All patients were consecutively enrolled and screened within one year (November 15, 2018, to November 14, 2019). The collected data included patient demographics and fall-related information.
Results
A total of 1,892 patients’ fall-related information were described. Most patients with hip fractures caused by falls were in the oldest old age group (60.4% in age group ≥80), with an overall average age of 80.7 (7.6) years. There were more females (n=1,325, 70.0%) than males (n=567, 30.0%). The majority lived in urban (n=1,409, 74.5%). Most falls (n=1,237, 67.3%) occurred during the daytime (6:01-18:00). There were 1,451 patients had their falls occurring at home (76.7%). Lost balance (n=1,031, 54.5%) was reported as the primary reason to cause falls. The most common activity during a fall was walking (n=1,079, 57.0%).
Conclusions
Although the incidence of fall-related hip fractures in China is unclear, preventing falls and fall-related hip fractures in older people remains an urgent health concern as the ageing society increases. Studies with larger sample size and diverse population are needed to robustly understand this growing epidemic.
Design of art teaching multimedia system based on genetic algorithms and computer network
Authors: Jing Chen
Published: February 2023

The application of multimedia technology and the development of computer networks always affect the lifestyle and behavioral habits of modern people, and also affect the education and learning methods of modern people. The genetic algorithm is called the form of calculation of the evolution algorithm, and it has the characteristics of parallelism and overallity and space search. This form is gradually brought into a large -scale cluster system. The article comprehensively considers the time, reliability, algorithm broadband and cost of each individual, and the demand display from 4 different aspects, and designed in the form of an adaptation function of the art teaching multimedia system to ensure the teaching service of teaching services quality. Eventually combined with the design of the courseware system of art teaching, and discussed the design and research and development of multimedia networks in the form of art teaching. R & D forms mainly include: preparation production of online courseware, development of online courseware, the operation and programming of online courseware, and the test and evaluation of online courseware. This design system research shows that the multimedia network system design under the art teaching is very important, which is the basis of the whole network teaching. For the system design and research of the whole art teaching understanding, it is the need to change and innovate technology, and also the only way for art design.
Research of Natural Language Processing Based on Dynamic Search Corpus in Cultural Translation and Emotional Analysis
Authors: Junya Wang
Published: February 2023

In order to enable students to directly face empirical data, summarize translation rules and learn translation skills, this paper studies the basis, motivation and methods of applying research dynamics in translation and teaching. Presenting data in class is the main method of dynamically searching corpora, which enables learners to face enough bilingual data that are easy to choose, and makes translation skills and teaching of translation of selected language items relatively focused. In recent years, the emotional analysis text has attracted academic scientists, and the professionals involved in the research, the use of research methods, and the cultural background related to language have become more and more extensive. In this paper, natural language processing is used to analyze emotions contained in translated texts. Natural language processing not only helps to manage the huge ability of data to efficiently translate text, but also helps to extract the hidden emotions in text translation. It only takes half the effort to achieve the multiplier effect. The multi label classification in natural language processing can reflect the information contained in emotion. The translated text is more detailed, which is helpful for further research.
Migraine-Like Headache Accompanied by Vertigo as Presenting Symptoms of Multiple Sclerosis (MS): a Case Report from Iran
Authors: Abrishamchi Fatemeh , Rajabi Ali
Published: February 2023

Background: Multiple sclerosis (MS) may have atypical presentations, one of whom being migraine-like headaches. This could be explained as following: the demyelination process in MS may involve brain structures or signaling pathways involved in migraine physiopathology, and therefore, simulate migraine headaches.
Case presentation: This case report is about a middle-aged male who developed a new-onset severe headache with migraine properties accompanied with vertigo, and was finally diagnosed with MS.
Conclusions: MS may have atypical presentations like severe headaches accompanied by additional symptoms, indicating the involvement of various brain structures; when working up such headaches, MS should be kept in mind besides other etiologies like vascular, infectious, and neoplastic conditions, and even primary migraine.
Dynamic behavior of time-fractional Benjamin-Bona-Mahony-Burger model in fluids
Authors: Tariq Kalim U. , Inc Mustafa , Hashemi Mir Sajjad
Published: February 2023

We investigate the Benjamin-Bona-Mahony-Burger model (BBM-B), a time-fractional model that is important for characterizing the dynamics of water waves, including those caused by cracked rocks, thermodynamics, a-harmonic crystal acoustic waves, and fluid acoustic-gravity waves. This results in the production of a wide range of travelling wave shapes, including bright, dark, periodic, optical, multi, and single-bell shaped forms. By choosing the proper values for the relevant parameters, the generated solutions are also visualized using 3D, contour, and 2D charts. Additionally , the governing model’s stability study is looked into. The outcomes demonstrate the success and effectiveness of the integration procedures, which may be used with several different models.
Stacked Ensemble Machine Learning for Porosity and Absolute Permeability Prediction of Carbonate Rock Plugs
Authors: Kalule Ramanzani , Abderrahmane Hamid Ait , Alameri Waleed , Sassi Mohamed
Published: February 2023

This study employs a stacked ensemble machine learning approach to predict carbonate rocks' porosity and absolute permeability with various pore-throat distributions and heterogeneity. Our data set consists of 2D slices from 3D micro-CT images of four carbonate core samples. The stacking ensemble learning approach integrates predictions from several machine learning-based models into a single meta-learner model to accelerate the prediction and improve the model's generalizability. We used the randomized search algorithm to attain optimal hyperparameters for each model by scanning over a vast hyperparameter space. To extract features from the 2D image slices, we applied the watershed-scikit-image technique. We showed that the stacked model algorithm effectively predicts the rock's porosity and absolute permeability.
WITHDRAWN: Document-Level Relation Extraction based Knowledge Graph Construction for Industrial Domain
Authors: Han Zhulin , Wang Jian
Published: February 2023

With the increasing complexity of production scenarios, a large amount of production information is stored in the enterprises of industrial domain. How to in-depth tap the value of complex document information and establish information links are important questions. In this paper, a framework of knowledge graph construction in industrial domain based on document-level relation extraction is proposed. To improve the accuracy of named entity recognition, domain knowledge is added to the word embedding matrix initialization of BiLSTM-CRF. For the task of relation extraction, this paper proposes the Knowledge-Aided Graph Inference network (KAGI), a relation extraction method for long paragraphs in industrial domain, which captures the complex interactions among entities by constructing document graph and innovatively adds knowledge representation to node construction and path inference through TransR. At the application level, BiLSTM-CRF and KAGI are used to construct knowledge graph from knowledge representation model and Chinese fault reports for steel production line, SPOnto and SPFRDoc respectively. The quality of the extracted knowledge graph meets the requirements of actual production environment applications. The result shows that KAGI can deeply mine the production reports and extract rich knowledge and patterns from them, which providing a solution for production management.
Codescent and bicolimits of pseudo-algebras
Authors: Osmond Axel
Published: February 2023

We categorify cocompleteness results of monad theory, in the context of pseudomonads. We first prove a general result establishing that, in any 2-category, weighted bicolimits can be constructed from oplax bicolimits and bicoequalizers of codescent objects. After prerequisites on pseudomonads and their pseudo-algebras, we give a 2-dimensional Linton theorem reducing bicocompleteness of 2-categories of pseudo-algebras to existence of bicoequalizers of codescent objects. Finally we prove this condition to be fulfilled in the case of a bifinitary pseudomonad, ensuring bicocompleteness.
MSC2020. 18N15; 18N10; 18C15;
Contradictory effects of machining conditions on wear in the main cutting zones of the twist drill
Authors: NACER MOKAS , SAMI BOUADILA , ABDELAZIZ AMIRAT
Published: February 2023

The present work is a fulfilment study on previous contribution presented by Mokas et al (2018) through investigation on the effect of chisel wear on the machinability of hardened C22 steel under drilling operations using twist high-speed steel (HSS) grade drill bits. Therefore, the evolution of wear in twist drill bits with respect to both flank and chisel edges has been reconsidered in order to sort out the most dominant wear rate in drill edges. Experimental investigation has been conducted on annealed and hardened C22 steel according to the planning experience methodology (L8). The input parameters are cutting regime elements, cutting speed, feed rate, and drill diameter; meanwhile, the output parameter is the chisel wear related to tool life. Results show that eventually, drilling annealed material generates much better tool life. Relatively to flank wear, chisel wear has great effect in some cutting conditions. In the annealing condition, flank wear is still most dominant and depends on the cutting speed. The higher cutting speed the lower the tool life. When drilling hardened material chisel wear becomes competitive with the flank wear as for some cutting parameters it is faster than flank wear. The feed rate is rather more influencing and the controversial effect of the cutting speed is confirmed with the chisel wear. Results are of great importance for industrial application where drilling hardened steel is required.
Investigation of the effects of sea, drinking, mineral and fountain water on microstrip patch antenna
Authors: Duman Mehmet , Mert Oğuzhan , Özkan Rabia , Ramazan Feyza , Yılmaz Yusuf , Duman Mustafa
Published: February 2023

Antennas are exposed to various environmental conditions while transmitting or receiving signals. Although they are intended to work outdoors or in areas that will not cause signal attenuation, they cannot always find such an environment. Water puddles in front of the antenna’s radiation pattern due to rain or other reasons cause wave attenuation. The fact that the electrical conductivity value in water is about 80 times higher than in air or space causes a significant decrease in the speed of electromagnetic waves. As a result of these problems, undesirable situations occur in the value of the scattering parameter S11, which is an important feature for antennas. In this study, the theoretical, simulation and production stages of a microstrip patch antenna are done. S11 values are measured by using a Nano-VNA for each of the different environment where salt water taken from the Black Sea coast, fresh water, mineral water, fountain water, and finally in the open air environment. The attenuation values are compared at 2.1 GHz frequency. As a result of the design, simulation and measurements, it has been seen that the main weakening is due to water. Water renders the antenna inoperable.