bluuebunny/crossref_metadata_2025 huggingface dataset:
Lividity
Authors: Rosenfield Kim
Published: May 2024

In Lividity, poet Kim Rosenfield works within the outskirts of language, draining it of connotation and excess. Using words and phrases culled from linguistics textbooks and language-learning manuals, Rosenfield invites the reader to experience the everyday vernacular as dislocated affect. What happens when language acts as organ donor? When language, the conveyor of our vulnerability, is transposed into new and often failing terrain? Are expressions of meaning vital enough to keep the organism functioning? What happens when meaning loses its moorings?
A clinical case of atopic dermatitis with a rapid positive effect from the use of a genetically engineered biological drug in a teenager
Authors: Churyukina E. V. , Portnyaga E. A.
Published: May 2024

Introduction. The instructions for the drug dupilumab indicate that the administration of a single loading dose on the first day leads to the rapid achievement of clinically effective concentrations within 2 weeks, which we saw in the example of our patient and her real clinical response to the first injection.

   Presentation of a clinical case. Under our medical supervision was a 17-year-old patient with severe atopic dermatitis, resistant to traditional therapy. Heredity for allergic pathology is burdened: the girl’s mother suffers from pollen allergy. Initially before the start of therapy: SCORAD — 88 points, EASI — 48.8 points, IGA — 4, blood eosinophils — 11 % (1188 cells/ml), total IgE — 1102.0 IU/ml; the content of nitric oxide in exhaled air (FeNO) is 30 ppb. On April 28, 2021, the patient was administered dupilumab at a dose of 600 mg. Assessment of atopic dermatitis control in points upon admission to the hospital 2 weeks after the first administration of dupilumab: on the SCORAD scale — 44.5 points; EASI — 13.8 points; IGA — 2 points, eosinophils — 9 % (1070 cells/ml); total IgE — 840 IU/ml; FeNO — 5 ppb.

   Conclusion. This clinical observation clearly illustrates the fact that patients with severe atopic dermatitis who don’t respond to first-line therapy can achieve positive clinical results after the first use of a recombinant human monoclonal antibody (IgG4).
Role of nonspecific risk factors in atopic dermatitis
Authors: Macharadze D. Sh. , Rassanova E. A. , Ruzhentsova T. A. , Galanina A. V. , Malyshev V. S.
Published: May 2024

The increasing prevalence of atopic dermatitis (AD) over recent decades suggests that environmental factors play an important role in the etiology and pathogenesis of the disease. Nonspecific factors refer to external (or exposomal) factors and include human and natural factors that influence the health of a population: for example, the socioeconomic status of the patient; climate, including air temperature, exposure to ultraviolet radiation, air pollution; and living in a city or rural area. Although studies have shown the influence of these factors on the course of AD, in general, none of them significantly increases or decreases the risk of developing the disease. This review briefly discusses studies on the role of nonspecific environmental risk factors and their impact on the course of AD in children and adults.
Implementation of Tafsîr Ûlul Albâb in Indonesian Islamic Education
Authors: Nurhadi Rofiq , Sert Hüseyin Emin , Wahyudi Jarot
Published: May 2024

Islam views the holy book as not only regulating matters of worship which are vertical between servants and God. The holy book is also seen as a guide for humans in managing all world affairs, including the world of education. The development of Islamic education today, directly or indirectly, often links its vision to the formation of the ûlul albâb generation (QS. Ali Imran; 190-194). Even though the vision is the same, the implementation of Islamic education often appears to vary. Islamic educational institutions in Indonesia exist in the form of pesantren, boarding schools, madrasah, and also schools. So what is meant by the ûlul albâb generation and how is Islamic education implemented in producing the ûlul albâb generation? This research is intended to find out the views of commentators regarding the meaning of ûlul albâb and at the same time to describe the models of Islamic education that have developed to date in Indonesia. This research is library research and the methods used are the maudlu'i (thematic) interpretation method and the qualitative descriptive method. Based on this research, it can be concluded that ûlul albâb is a self-image that combines academic qualities, spirituality, and charity. In this perspective, Islamic education is a process of improving the quality of humanity in its various dimensions, namely making scholars who believe and do good deeds. To achieve this goal, Islamic education in Indonesia is developing an integrative education model, namely institutional integration and curriculum integration.
Reineccius and His History of Ancient Thrace from 1595
Authors: Mitrev Georgi , Iliev Jordan
Published: May 2024

This article discusses a study by the historian Reineccius (1541 – 1595) on aspects of the history of Ancient Thrace and the Thracians. Until now, this work – part of a comprehensive exploration entitled “Historia Ivlia, Siue Syntagma Heroicvm” – has remained unknown to modern researchers and they assumed, that scholarly interest in Thracian history emerged only in the first half of the 18th century. The article begins with brief notes on Reineccius’s biography and works, followed by an overview of the information about the Thracians in his book. It is noted that, in the section titled “Regnum Thracium” the author sequentially examines ancient evidence concerning the geographical scope of Thrace, the strongest Thracian tribes, the Thracians outside Thrace; afterwards he structures the available at his time information of ancient writers about Thracian kings, specifying their family relationships. Special attention is given to the Odryssian kings, constituting about a third of the content. Other kingdoms, which today are considered part of the Thracian ethno-cultural community, are examined in separate sections: Bosphorus, Paeonia and Pannonia, Getica, Dacia and Moesia. The text is complemented by stems indicating established connections between dynasties and kings. Reineccius’s work is remarkable for its rigorous research elements and strict adherence to ancient texts, correctly cited. Undoubtedly, due to these qualities, this study on Ancient Thrace has influenced research on the topic for the next two centuries. Based on the presented facts, it is concluded that Reineccius’s work can be considered the first attempt to systematize ancient information about Thrace and the Thracians.
Analysis of the Digital Competencies of Physics Teachers in Bulgaria According to the Digcompedu Framework
Authors:   Sofia University “St. Kliment Ohridski’’, Kotseva Ivelina , Gaydarova Maya
Published: May 2024

This article is a review of the reports delivered by Bulgarian physics teachers on the National Conference on Physics Education in the period 2007 – 2023 in the context of their digital competencies’ development. Its main goal is to provide a comprehensive exploration of the integration of digital technologies in physics education, emphasizing their role in enhancing teachers’ and learners’ digital competence across various dimensions. The study emphasizes on the significance of digital technologies in fostering digital literacy, communication, collaboration, content creation, responsible use, and problem solving among students in alignment with the DigCompEdu framework. Digital technologies, including virtual labs, simulations, coding platforms, and mobile apps, offer students dynamic and interactive learning experiences, promoting information and media literacy and hands-on experimentation.
The role of digital competence in school historical education
Authors:   Sofia University, Misheva Katya
Published: May 2024

The publication presents an analysis of the place and role of digital competences embedded in school documentation and curriculum in history and civilizations. A look at the digital competence of the pedagogue is presented, as well as the one that the learner should be formed and applied. Based on the recommendations set out in the European Digital Competence Framework (DigComp) and the analysis made, groups of digital competences are formed, which it is desirable for the modern teacher to master. The analysis will be compared with foreign practices, thus bringing out the strengths and weaknesses in the digitalization of school historical education.
O uso de IA em ambientes de aprendizagem personalizados
Authors: Felippe Kellin Rangel Callegari , Souza Deise Cordeiro de , Melo Júnior Hermócrates Gomes , Carmo Jonathan Porto Galdino do , Andrade Filho Marcos Antonio Soares de , Santos Renato Fernandes dos , Pedra Rodrigo Rodrigues , Demuner Jocelino Antonio
Published: May 2024

Este estudo aborda o uso da Inteligência Artificial (IA) para desenvolver ambientes de aprendizagem personalizados, focando em sua capacidade de adaptar o ensino às necessidades individuais de cada aluno. O objetivo principal foi avaliar a eficácia da IA em personalizar a educação, visando uma resposta mais direcionada e eficiente aos diversos perfis estudantis. Para isso, foi realizada uma revisão bibliográfica, na qual se analisou literatura especializada para compreender as diversas aplicações, benefícios e desafios da IA no âmbito educacional. Os resultados demonstraram que a IA tem um potencial significativo para personalizar o aprendizado, adaptando o conteúdo educacional conforme as características e necessidades de cada estudante, e proporcionando feedback imediato e adaptativo. Essa personalização permite um avanço mais alinhado com o ritmo e estilo de aprendizado de cada aluno, promovendo uma educação mais inclusiva e eficiente. No entanto, o estudo também revelou desafios substanciais, tais como a equidade no acesso às tecnologias de IA e questões éticas, especialmente no que tange à privacidade e ao tratamento dos dados dos alunos. Preocupações com a segurança dos dados e a necessidade de sistemas que garantam a privacidade foram identificadas como barreiras críticas à implementação efetiva da IA. As considerações finais apontam que, embora a IA apresente um potencial transformador para o ensino, sua implementação deve ser gerida. É imperativo que se maximize os benefícios enquanto se minimizam os riscos associados, garantindo que o uso de IA em ambientes educacionais seja justo e seguro. Portanto, pesquisas futuras são necessárias para explorar mais a fundo como a IA pode ser implementada em diferentes contextos educacionais, promovendo um ambiente de aprendizado mais adaptativo e responsivo.
Desafios contemporâneos na formação de professores: conectando teoria e prática
Authors: Pereira Sandra Maria Jerônimo , Araújo Acácia Regina Silva de , Monteiro Gabriela Clotilde dos Santos , Nogueira Lívia Rodrigues , Silva Márcio Rosário da , Braga Neide Rafael Alves , Rocha Rossana da , Fernandes Wélida Verdam de Souza
Published: May 2024

Este estudo explora os desafios contemporâneos enfrentados na formação de professores, enfatizando a essencial conexão entre teoria e prática educacional. A pesquisa investigou a persistente lacuna entre o conhecimento teórico oferecido nos cursos de formação de professores e as complexas realidades práticas das salas de aula. O principal objetivo foi identificar e analisar esses desafios, desenvolvendo estratégias para uma integração mais eficaz entre os aspectos teóricos e práticos da educação. Para isso, adotou-se uma metodologia de revisão bibliográfica, analisando qualitativamente dados extraídos de artigos, teses e documentos oficiais relevantes ao tema. Os resultados obtidos revelaram que a ausência de práticas pedagógicas que integrassem teoria e prática nos currículos representa uma barreira significativa para a eficácia da formação de professores. A pesquisa também destacou a necessidade crítica de inovações pedagógicas que permitam aos futuros educadores experimentar e refletir sobre suas práticas em ambientes controlados e seguros. Isso inclui a implementação de simulações e uso de tecnologia educacional avançada, proporcionando experiências mais alinhadas com as exigências contemporâneas do ensino. As considerações finais do estudo enfatizam a importância de revisões curriculares adaptativas, bem como a necessidade de uma formação docente mais alinhada às necessidades práticas do ensino. Além disso, sugere-se a continuação de pesquisas focadas em aprimorar a integração das metodologias pedagógicas e inovadoras na formação de professores, visando superar as lacunas identificadas e melhorar a qualidade e relevância da educação futura. Este estudo contribui para a discussão sobre a formação de professores, ressaltando a urgência de abordagens que considerem tanto a teoria quanto a prática como elementos complementares e indissociáveis na educação.
Polysachrides of Viscum album L.
Authors: Аджиахметова С.Л. , Червонная Н.М. , Поздняков Д.И. , Оганесян Э.Т.
Published: May 2024

Статья посвящена вопросам выделения и исследования сезонной динамики накопления полисахаридов листьями омелы белой (Viscum album L.), а также изучения некоторых их физико-химических характеристик. Установлены отчетливые внутрисезонные различия накопления пектиновых веществ (ПВ). Содержание ПВ в перезимовавших листьях весной было примерно в 1,5 раз ниже, чем в осенний период. Показано также разнообразие мономерного профиля исследуемых ПВ. Рассчитана средняя молекулярная масса ПВ, выделенных из листьев омелы белой, произрастающей на яблоне домашней (Malus domestica Borkh.) и тополе черном (Populus nigra L.), которая составила 2154,43 г/ моль и 1695,19 г/ моль, соответственно.Обнаружено, что наибольшее содержание ПВ (8,02 ± 0,31) наблюдается в листьях V. album, произрастающей на P. nigra, а уроновых кислот (71,34 ± 1,48 %) в листьях V. album, произрастающей на M. domestica. На основе анализа сезонной динамики накопления ПВ, можно сделать вывод, что оптимальным временем для заготовки сырья является осенний период.

The article deals with the identification and study of the seasonal dynamics of the accumulation of polysaccharides isolated from the leaves of Viscum album L., as well as the study of some of their physicochemical characteristics. Distinct intraseasonal differences in the accumulation of pectin substances (PS) have been established. The content of HP in overwintered leaves in spring was approximately 1.5 times lower than in autumn. An analysis of the data obtained indicates the diversity of the monomeric profile of the studied HPs. The average molecular weight was calculated, which was 2154.43 g/mol and 1695.19 g/mol for pectin substances isolated from the leaves of Malus domestica Borkh. and Populus nigra L., respectively. It was found that the highest content of PV (8.02 ± 0.31) is observed in the leaves of V. album growing on P. nigra, and uronic acids (71.34 ± 1.48 %) in the leaves of V. album growing on M . domestica. Based on the dynamics of HP accumulation, it can be concluded that the optimal time for harvesting raw materials is the autumn period.
Mineral complex of large plantain leaves
Authors: Дьякова Нина Алексеевна
Published: May 2024

Целью исследования явилось изучение макро- и микроэлементного состава листьев подорожника большого. Заготовку лекарственного растительного сырья (ЛРС) осуществляли в период цветения растения в Воронежском государственном природном биосферном заповеднике. Микроэлементный состав ЛРС определяли методом масс-спектроскопии с индуктивно связанной плазмой на приборе «ELAN-DRC». Выявлено, что содержание микроэлементного комплекса составляет 6,15 % всего элементного состава листьев подорожника большого в пересчете на абсолютно сухое сырье, определено 59 элементов, макроэлементы – 94,5 % элементного состава. Основу макроэлементов составляет калий (более 26 мг/г), а также кальций (более 24 мг/г). Эссенциальные микроэлементы составляют 2,94 % общего минерального комплекса листьев подорожника большого. Среди них наибольшее содержание отмечено для кремния (более 1,0 мг/г), железа (более 0,7 мг/г). Доля токсичных и малоизученных элементов в общем минеральном комплексе листьев подорожника большого составляет 2,60 %. Наибольшее содержание отмечено для алюминия (1257 мкг/г), бария (146 мкг/г), стронция (117,7 мкг/г), титана (64,5 мкг/г), рубидия (7,1 мкг/г), циркония (2,0 мкг/г). Результаты исследования показали богатый макро- и микроэлементный состав листьев подорожника большого, заготовленных в Воронежской области, что может быть использовано в медицинской и фармацевтической практике для создания лекарственных препаратов и биологически активных добавок с целью коррекции физиологических норм содержания элементов в организме человека.

The purpose of the study was to study the macro- and microelement composition of the leaves of the plantain large. Preparation of medicinal plant raw materials was carried out during the flowering of the plant in the Voronezh State Natural Biosphere Reserve. The microelement of medicinal plant raw materials was determined by mass spectroscopy with inductively coupled plasma on the ELAN-DRC device. It was revealed that the content of the microelement complex is 6.15 % in terms of absolutely dry raw materials, 59 elements were determined. Macroelements make up 94.5 % of the total elemental composition of the leaves of the large plantain. The macroelements are based on potassium (more than 26 mg/g), as well as calcium (more than 24 mg/g). Essential trace elements make up 2.94 % of the total mineral complex of the leaves of the large plantain. Among them, the highest content was noted for silicon (more than 1.0 mg/g), iron (more than 0.7 mg/g). The share of toxic and poorly studied elements in the total mineral complex of plantain leaves is 2.60%. The highest content was observed for aluminum (1257 ?g/g), barium (146 ?g/g), strontium (117.7 ?g/g), titanium (64.5 ?g/g), rubidium (7.1 ?g/g), zirconium (2.0 ?g/g). The results of the study showed a rich macro- and microelement composition of the leaves of a large plantain, which can be used in the medical and pharmaceutical practice of creating drugs and biologically active additives for correcting physiological norms of the content of elements in the human body.
Modification of the method for the quantitative determination of flavonoids in horsetail grass (Equisetum arvense L.)
Authors: Лабковская Майя Викторовна , Шмыгарева Анна Анатольевна , Куркин Владимир Александрович
Published: May 2024

В настоящей работе представлены варианты модификации методики стандартизации лекарственного растительного сырья хвоща полевого (Equisetum arvense L.). Целью исследования являлось установление оптимальных условий, времени и метода экстракции для получения максимального выхода суммы флавоноидов в сырье в пересчете на кверцетин. Метод количественного анализа травы хвоща полевого основан на использовании метода спектрофотометрии при аналитической длине волны 430 нм, в пересчете на кверцетин. Извлечение биологически активных веществ осуществляли на кипящей водяной бане, в течение 60 минут, в соотношении (сырье : экстрагент – 1:100), концентрация спирта составила 50 %. Данные условия экстракции позволили получить максимальный выход флавоноидов, который составил 1,67 ± 0,07 %. В ходе проведения эксперимента при экстрагировании был дополнительно использован ультразвук в сочетании с водяной баней, однако выход флавоноидов был существенно меньше, соответственно, следует вывод о разрушительном воздействии ультразвука на флавоноиды в траве хвоща полевого. Предложенные нами условия экстрагирования в дальнейшем можно рекомендовать для получения экстрактов с целью изготовления лекарственных препаратов на основе сырья травы хвоща полевого.

This paper presents options for modifying the methodology of standardization of medicinal plant raw materials of horsetail (Equisetum arvense L.). The purpose of the study was to establish optimal conditions, time and extraction method to obtain the maximum yield of the amount of flavonoids in raw materials calculated on quercetin. The method of quantitative analysis of horsetail herbs is based on the use of spectrophotometry at an analytical wavelength of 430 nm, calculated on quercetin. The extraction of biologically active substances was carried out in a boiling water bath, for 60 minutes, in the ratio (raw materials:extractant 1:100), the alcohol concentration was 50%. These extraction conditions allowed to obtain the maximum yield of flavonoids, which was 1.67±0,07%. During the experiment, ultrasound was additionally used during extraction, in combination with a water bath, but the yield of flavonoids was significantly less, respectively, the conclusion follows about the destructive effect of ultrasound on flavonoids in horsetail herbs. The extraction conditions proposed by us can be further recommended for obtaining extracts for the purpose of manufacturing medicines based on the raw materials of horsetail herbs.
Influence of osteopathic correction on postural balance and quality of life of patients with amputations of the lower extremities below the knee
Authors: Мохов Дмитрий Евгеньевич , Трегубова Елена Сергеевна , Потехина Юлия Павловна , Колышницын Никита Юрьевич
Published: May 2024

Цель исследования: изучить влияние остеопатической коррекции на постуральный баланс и качество жизни пациентов с ампутациями нижних конечностей на уровне голени.Материалы и методы. Обследованы 76 пациентов (54 мужчины и 22 женщины, средний возраст 57 лет) с ампутациями нижних конечностей на уровне голени с помощью стабилографии в амбулаторных условиях на кафедре остеопатии СЗГМУ им. И.И. Мечникова. Пациенты были разделены случайным образом на 2 группы: основная группа (n = 41), получавшая остеопатическую коррекцию и контрольная группа (n = 35), получавшая мнимую терапию. Обе группы были поделены на подгруппы в зависимости от причины ампутации: травматические и сосудистые. Всем пациентам стабилография проводилась 4 раза: до и после первой остеопатической коррекции или мнимой терапии, а также до и после второго приема. Оценка качества жизни с помощью опросника SF-36 проводилась до исследования и на 30 и 90 день исследования. Результаты. Метод стабилографии объективно подтвердил положительное влияние остеопатической коррекции на постуральный баланс у пациентов ампутации (P < 0,05). Исследование качества жизни показало стойкое улучшение физического и психологического компонента качества жизни у пациентов, получающих остеопатическую коррекцию.

Purpose of the study: to study the effect of osteopathic correction on postural balance and quality of life of patients with lower limb amputations at the tibia level. Materials and methods. 76 patients (54 men and 22 women, average age 57 years) with amputations of the lower extremities below the knee were examined using stabilography on an outpatient basis at the Department of Osteopathy of North-Western State Medical University named after. I.I. Mechnikov. The patients were randomly divided into 2 groups: the main group (n = 41), which received osteopathic correction, and the control group (n = 35), which received sham therapy. Both groups were divided into subgroups depending on the cause of amputation: traumatic and vascular. All patients underwent stabilography 4 times: before and after the first osteopathic correction or sham therapy, as well as before and after the second appointment. Quality of life assessment using the SF-36 questionnaire was carried out before the study and on days 30 and 90 of the study. Results. The stabilography method objectively confirmed the positive effect of osteopathic correction on postural balance in amputation patients (P < 0.05). A study of the quality of life showed a persistent improvement in the physical and psychological components of the quality of life in patients receiving osteopathic correction.
Development and Application of Elementary School AI Education Program Using the International Baccalaureate (IB) Primary Years Programme (PYP) Approach
Authors: Kim Bom-sol , Go Eun-jung , Moon Woo-jong , Kim Bong-chul , Kim Jong -hoon
Published: May 2024

The objective of this study is to enhance elementary school students' foundational understanding of artificial intelligence (AI) and to foster their Computational thinking. This goal was realized through the creation of an AI education program integrating the ADDIE model and the International Baccalaureate (IB) Primary Years Programme (PYP) teaching methodology. Before developing the educational program, we conducted a preliminary needs analysis with 60 fifth-grade students from IB World School P Elementary and 36 staff members, aligning with the stages of the ADDIE model. Drawing from the outcomes of this preliminary needs analysis, we opted for the transdisciplinary theme 'How the world works,' as it resonated most aptly with AI-related content, as determined by participating educators. Real-life AI-based concepts were seamlessly woven into the educational material. Throughout the program, students actively engaged in exploratory activities centered on the chosen transdisciplinary theme and central concept. Collaborating on team projects, they collectively tackled problem-solving processes, completing activities and assignments aimed at fostering self-directed learning. To assess the effectiveness of the developed educational program on students' computational thinking, pre- and post-tests were administered. Validation results underscored that the program made a significant contribution to the enhancement of Computational Thinking among the participating students.
Non-Tobacco Nicotine Dependence and Rates of Postoperative Complications in Total Knee Arthroplasty: A Propensity-Matched Comparison
Authors: DeShazo Sterling J. , Crossnoe Remington C. , Bailey Luke C. , Rogers Jackson M. , Naeger Patrick A.
Published: May 2024

Introduction:

Tobacco use elevates the incidence of postoperative complications and remains a key modifiable risk factor of perioperative surgical optimization. It remains unclear whether non-tobacco nicotine dependence confers an increased risk of surgical complications. This study evaluates postoperative complications in patients with non-tobacco nicotine dependence for total knee arthroplasty (TKA).

Methods:

We queried the TriNetX health database using Current Procedural Terminology and International Classification of Diseases, 10th Revision (ICD-10) codes and identified two cohorts for evaluation. Cohort A was defined as patients who had a TKA; had a dependence on nicotine; did not have nicotine dependence to cigarettes, chewing tobacco, other tobacco products; and were between the ages of 35 and 90 years. Cohort B was defined as patients who had a TKA but did not have a dependence on nicotine or a personal history of nicotine dependence and were between the ages of 35 and 90 years.

Results:

This study analyzed a total of 10,594 non-tobacco nicotine-dependent patients and 175,079 non-dependent patients who underwent TKA. In the analysis of propensity-matched cohorts, non-tobacco nicotine-dependent patients demonstrated an increased rate of various postoperative complications within 90 days. Dependent patients saw a significantly increased risk of infection after a procedure (P < 0.001), deep vein thrombosis (P < 0.001), pulmonary embolism (P < 0.001), sepsis (P = 0.0065), and prosthetic joint infection (P = 0.0361) and a higher 3-year revision rate (P = 0.0084).

Discussion:

Non-tobacco nicotine dependence demonstrated an increased associated risk of postoperative surgical complications for patients undergoing TKA. Orthopaedic surgeons should consider evaluating non-tobacco nicotine dependence within their surgical optimization protocol.

Level of evidence:

Level III, Prognostic.
Wound-Healing Effects of Common Antineoplastic Agents and Perioperative Considerations for the Orthopaedic Surgeon
Authors: Okay Erhan , Connolly Joseph J. , Gonzalez Marcos R. , Lozano-Calderon Santiago A.
Published: May 2024

In oncologic patients, optimal postoperative wound healing is crucial for the maintenance of systemic therapies and improved survival. Although several risk factors for postoperative wound complications have been identified, the clinical effect of new antineoplastic agents on wound healing remains uncertain. The available literature on the effect of antineoplastic agents in wound healing is complex to analyze because of other confounding risk factors such as radiation therapy and certain patient-specific variables. Available perioperative drug recommendations are based on database opinion and case reports from adverse event alerts. This review highlights the characteristics of old and new antineoplastic agents commonly used in the treatment of sarcoma, carcinoma, and other cancers and their potential effects on the wound-healing process. It also aims to provide perioperative treatment cessation recommendations to guide orthopaedic surgeons and prevent drug-related wound complications to the fullest extent possible.
Effect of Dental Posts used in Restoring Badly Broken Primary teeth
Authors: Alkayakh Tebra , Aldarewesh Abdulrahim
Published: May 2024

Aim: The aim of this study was to evaluate the shear bond strength (SBS) and fracture resistance (FR) of endodontically treated primary anterior teeth restored: with composite resin reinforced with three different post systems. (1) Ribbon fiber posts; (2) glass fiber posts; and, (3) orthodontic metal wire posts cemented by glass ionomer cement (GIC).Methods: This experimental study conducted in a controlled laboratory setting was performed on 60 extracted human primary maxillary incisors. Samples were randomly divided into 3 groups of 20 teeth each: group 1 (ribbon fiber posts and composite core); group 2 (glass fiber posts and composite core) and group3 (orthodontic metal shaped wire posts and composite core). Each main test group subdivided into two subgroups (I, II) of 10 teeth each according to the laboratory test used, shear bond and fracture strength respectively. Mounted specimens were subjected to an Instron testing machine.Results: For shear bond strength, Stainless steel group recorded the highest mean value (14.4±2.4Mpa) followed by Glass fiber group (5.6±4.01Mpa) while ribbon fiber group recorded the lowest mean value (4.9±2.8Mpa). The difference between all groups was statistically significant (p<0.05) as indicated by ANOVA test. For fracture resistance, Glass fiber group recorded the highest mean value (146.018±37.96N) followed by ribbon fiber group (133.3±38.222N), while Stainless steel group recorded the lowest mean value (111.48±30.522N). The difference between all groups was statistically significant (p<0.05) as indicated by ANOVA test.Conclusion: orthodontic metal wire posts and glass fiber posts proved their advantages regarding the shear bond& fracture resistance respectively.
Association of ABO/Rh Blood Group with Hypertension in Pre and Postmenopausal Libyan women
Authors: Ashawesh Mahmoud , Bashimam Olla , Jebali , Falak
Published: May 2024

BACKGROUND AND AIM: Hypertension is a prevalent and significant public health issue worldwide, affecting a substantial portion of the population. While various risk factors have been implicated in the development of hypertension, including genetics, lifestyle, and hormonal changes, the role of ABO/Rh blood groups in hypertension remains underexplored, particularly in different stages of Libyan women’s life. This research study aimed to investigate the potential association between ABO/Rh blood groups and hypertension in both pre- and post-menopausal Libyan women.
METHODOLOGY: A cross sectional study was conducted over a four-month period on a diverse cohort of women aged 35 to 75 years. It involved a total of 200 hypertensive women divided into pre- (n=100) and post-menopausal (n=100) groups. It took place at Tripoli University Hospital, Tajoura Heart Centre and Total Care Clinic. Data were collected through structured interviews, clinical examinations, and blood sample analyses. Blood pressure (BP) measurements and blood group typing were performed using standard medical procedures. A statistical analysis was performed using SPSS program version 26.0.
RESULTS: The distribution of ABO blood groups shows that blood group O is the most prevalent blood group among samples (58% in the pre-menopausal and 41% in post-menopausal hypertensives), whereas blood group AB is the least prevalent (only 9% in the pre-menopausal and 7% in post-menopausal hypertensives). One hundred and eighty-one (90.5%) were Rh +ve. Analysis of data revealed significant differences in age distribution as well as in the percentages of Rh +ve and Rh -ve blood groups among pre- and post-menopausal women (p<0.05). However, there was no statistically significant difference in the mean values of BP indices between ABO/Rh blood groups (p>0.05).CONCLUSION: This study showed that ABO/Rh blood group system does not significantly affect BP indices among the pre-menopausal and post-menopausal women. Findings of present study also illustrated that age could potentially influence the connection between blood groups and hypertension. Additionally, among ABO/Rh blood groups, the most observed type was 'O.' However, further investigation is necessary to validate these initial results and better understand the underlying mechanisms behind this relationship
Prevalence and risk factors of erythropoiesis stimulating agents hyporesponsiveness in chronic hemodialysis patients attending nephrology center of Benghazi
Authors: Ezwaie Mohamed , Ezwaie Ragheda , Younis Sarah , Elfigih Seraj
Published: May 2024

Background: Anemia is quite prevalent in end stage renal disease patients. Despite availability of different forms of erythropoiesis stimulating agents, many end stage renal disease patients are anemic according to National Kidney Foundation’s Kidney Disease Outcomes Quality Initiative guidelines. Patient and methods: we conduct a cross sectional study between May 2022 and July 2022, targeting adult chronic hemodialysis patients, to investigate the prevalence of erythropoiesis stimulating agents hyporesponsiveness, to assess if patients are receiving the appropriate weight-based dosing of these agents, and to identify additional risk factors behind inadequate response to therapy.390 end stage renal disease patients are receiving chronic hemodialysis at nephrology center of Benghazi. Incident hemodialysis patients, patients with other hematological disease or with malignancy are excluded. Finally, 150 patients met the inclusion criteria and enrolled in the study. Results: 100 (66.7%) are male, and 50 (33.3%) are females. Age is 50.6 ±13.2 years. Erythropoiesis stimulating agents hyporesponsiveness is prevalent in chronic hemodialysis patients, 130 (86.7%) patients are anemic as their Hb levels were <11 g/dl, while only 20 (13.3%) patients have Hb levels of >/=11g/dl. There is a significant relationship between gender and ESA response, as hyporesponsiveness is more observed in male patients (P < .005). We find that 105 (70%) patients are receiving an appropriate weight-based dose, while only 45 (30%) patients were giving an inappropriate dose. When the relationship between ESA dosing and patients' response to ESA is examined, we find, that despite receiving the appropriate dose, 90 (60%) patients are ESA hyporesponsive, while only 15 (10%) are responsive to the appropriate weight-based dose. However, no statistical association is found between ESA hyporesponsiveness and age or weekly hours of dialysis. Conclusion: despite receiving an appropriate dosage of ESA, our study population shows high prevalence of ESA hyporesponsive anemic state. New strategies should be applied to detect risk factors and adopt therapeutic measures to reduce its high prevalence in hemodialysis population.
Profil Keterampilan Berpikir Analisis Calon Guru IPA Pada Perkuliahan Fisika Dasar Berbantuan Media Virtual Laboratory
Authors: Rochim Roudhoutul Aulia , Af’idah Noer , Fitriyah Lina Arifah , Wijayadi Andri Wahyu , Falah Fajrul
Published: May 2024

Keterampilan berpikir analitis sangat penting bagi siswa untuk mengatasi masalah secara efektif. Fisika merupakan komponen penting dari IPA yang membutuhkan kemampuan kognitif tingkat tinggi untuk pemecahan masalah. Investigasi ini mengambil bentuk studi deskriptif yang bertujuan untuk menggambarkan kemahiran berpikir analitis siswa. Kelompok yang diteliti terdiri dari 24 individu yang terdaftar dalam kursus fisika dasar. Tes deskriptif berfungsi sebagai alat utama dalam penelitian ini, khusus dirancang untuk menilai indikator keterampilan berpikir analitis yang mencakup diferensiasi, organisasi, dan korelasi. Analisis data mengungkapkan bahwa kemampuan berpikir analitis siswa didistribusikan sebagai berikut: 16,67% menunjukkan keunggulan, 79,16% menunjukkan kemahiran, dan 4,17% menunjukkan ketidakmampuan. Selanjutnya, rincian kecakapan berpikir analitis siswa di berbagai indikator mengungkapkan skor 95,14 (sangat baik) untuk diferensiasi, 99,30 (sangat baik) untuk organisasi, dan 51,74 (adil) untuk korelasi.
Analisis Pengaruh Tingkat Suku Bunga, Rasio Kecukupan Modal dan Ukuran Bank terhadap Harga Saham Bank-Bank Komersial yang Terdaftar di Bursa Efek Indonesia
Authors: Tahu Gregorius Palus , Indrayoni Ida Ayu Putu , Widnyana I Wayan , Susilo Dominicus Djoko Budi
Published: May 2024

Harga saham merupakan faktor yang sangat penting dan harus diperhatikan oleh investor dalam melakukan investasi, karena karena harga saham menunjukan prestasi emiten. Penelitian ini dilakukan untuk menganalisis pengaruh tingkat suku bunga, rasio kecukupan modal, dan ukuran bank terhadap harga saham bank-bank komersial yang terdaftar di Bursa Efek Indonesia selama periode 2016-2021. Tujuan utamanya adalah untuk memahami dinamika pasar modal dan memberikan wawasan tentang faktor-faktor yang mempengaruhi harga saham di sektor perbankan. Penelitian ini menggunakan pendekatan kuantitatif dengan data sekunder, melibatkan analisis regresi linier berganda. Sampel penelitian terdiri dari 11 bank komersial yang terdaftar di Bursa Efek Indonesia, dipilih melalui purposive sampling. Analisis dilakukan menggunakan statistik deskriptif, uji asumsi klasik, dan uji hipotesis. Hasil penelitian menunjukkan bahwa tingkat suku bunga tidak memiliki pengaruh signifikan terhadap harga saham, sedangkan rasio kecukupan modal memiliki pengaruh negatif signifikan terhadap harga saham, dan ukuran bank memiliki pengaruh positif signifikan terhadap harga saham. Analisis ini memberikan bukti bahwa faktor internal bank memiliki dampak yang lebih signifikan dibandingkan dengan faktor eksternal seperti suku bunga dalam menentukan harga saham. Penelitian ini menyimpulkan bahwa rasio kecukupan modal dan ukuran bank merupakan faktor penting yang mempengaruhi harga saham di sektor perbankan. Sementara itu, tingkat suku bunga, meskipun sering dianggap penting, tidak menunjukkan pengaruh signifikan dalam konteks ini.
Socialization of Introduction to Understanding The World of The Financial Profession for Students At State 9 Vocational High School, West Jakarta
Authors: Sormin Feber , Tarmidi Deden
Published: May 2024

Purpose of activity PkM with title Socialization introduction Understanding the World of Professionals in the field finance For students at vocational schools for increase interests, hopes and interests For dream So expert profession field finance . Constitution Number 4 of 2023 concerning Financial Sector Support and Support (PPSK) consists of from Public Accountant (AP), Accountant Practicing (AB), Actuary, Public Appraiser, Tax Consultant , Notary , Legal Consultant , Financial Services Sharia Expert ; and other professions determined by the Ministry, Institution, or supervisory and supervisory authority profession related , necessary introduced my friend interest .Problems : 1). Many Accounting Vocational School students However only few have​ objective become expert Profession Finance like Accountant besides profession finance other. 2). Current PPPK statement Socialization of Professional Services Finance in Bandar Lampung delivered No A little students who have low interest, and yet understand How become a profession reliable finances.​ 3). Guard sustainability need power profession field finance in accordance development. The method used is : 1). Extension methods, 2). Question and answer method, 3 ). Demonstration Method . Devotion public This held especially for student School Intermediate Vocational School (SMK) Negeri 9, West Jakarta. Activity results: With extension method past presentation, Q & A, Demonstration​ past the practitioner explains experience his profession direct to student /I has be a Solution: 1). Produce interest and motivation vocational school students who have objective For become power expert profession finance, 2). Vocational school students who want to working in the professional world Finance understand better​ major studies his lectures, 3). give knowledge in practice about profession finance including required competencies​ owned To use add interest interest take Major Accounting, 4). Participant more know method For become a power expert / profession in the field of Financial Services, 5). Activity This has give contribution input to party government, academics, and parties other.
Node Scheduling Scheme for Wireless Sensor Networks with Partial Coverage
Authors: Bajaber Fuad
Published: May 2024

Sensor nodes in a wireless sensor network are distributed across an area for data collection. These nodes have basic capabilities in terms of interfaces and components,  and they often operate in dynamic, hostile environments. Sensor networks present numerous challenges: they are dispersed, generate constant high rates data streams, function in dynamic and time-changing situations; and may involve a large number of sensors. Sensor nodes have enough power to transmit their readings to a central high-performance computing unit for processing. Sensor networks generate data streams, which are sequences of real-time data records characterized by their high data rates that consume significant network computing resources. However, only a few studies address the issue of collecting highly redundant data, leading to nodes wasting energy by sending redundant information to a central high-performance computing unit. Improved scheduling tactics can  help reduce energy consumption in sensor nodes. This research developed a Node Scheduling Scheme for Wireless Sensor Networks with Partial Coverage (NSPC). Partial coverage can be obtained by dividing the area of interest into smaller sub-regions and determining the monitoring intensity for  each sub-region by sensor nodes. Various strategies, such as clustering and scheduling, can be employed to accomplish partial coverage. Considering partial coverage when designing a WSN is crucial, as it can enhance network stability and reliability while reducing the cost and energy consumption of each sensor nodes.
Lane Reconstruction for Self-Driving Vehicles on Dynamic Road Networks
Authors: Chuttur Y. , Kaudeerally R. , Nazurally A.
Published: May 2024

Lane detection is a crucial task that involves identifying lane lines and proper markings on road structures. The field of lane detection has gained significant attention due to the increasing use of autonomous vehicles and ADAS systems, as they require robust lane detection systems to navigate safely in complex environments. While previous studies have focused on lane detection in various scenarios, lane line reconstruction for dynamic road networks has been largely overlooked. To address this gap, we propose a novel approach to reconstruct lane lines for dynamic road networks using roadblocks, specifically red and white striped markers, as cues. To evaluate the effectiveness of our proposed approach, we first built and labeled our own dataset by extracting 1854 frames from recorded videos. We trained a Faster-RCNN V2 model on 80% of the dataset to detect the roadblocks and used the OpenCV DNN module, along with a range of techniques, such as ROI selection, color selection, region masking, and polynomial and linear fittings for lane detection and reconstruction. Our approach successfully reconstructed the left, middle, and right lane lines, achieving an overall accuracy of 68%, a recall of 73%, and a precision score of 73% on an unseen set of 50 images. Our study contributes to the field by proposing a novel approach for reconstructing lane lines in dynamic road networks using roadblocks as markers. This approach has the potential to enhance the accuracy and robustness of lane detection systems in complex environments. Furthermore, our work addresses a gap in the existing literature and provides insights for future research in this area.
Prediction of Thyroid Disease using Machine Learning Approaches and Featurewiz Selection
Authors: Shiuh Tong Lim , Khai Wah Khaw , Xin Ying Chew , Wai Chung Yeong
Published: May 2024

Thyroid disease is one of the most disturbing hormonal disorders faced by the global population. To help the healthcare industry to diagnose the disorder rapidly and accurately, supervised machine learning algorithms and feature selection were introduced to play an essential role in predicting whether a patient has developed thyroid disease from his/her various characteristics. Therefore, in this work, a new feature selection library was introduced, which was the Featurewiz in the Python library. The goals were to present the performance of the Featurewiz library and to decide on a remarkable model for thyroid disease prediction among several machine learning models, such as Decision Tree, K-Nearest Neighbor, Logistic Regression, Naïve Bayes, Support Vector Classifier, and ensembled machine learning algorithms (Random Forest and Extreme Gradient Boost). A data set consisting of records of thyroid patients in Australia was used to develop the machine-learning models. After the data set was cleaned, exploratory data analysis was carried out. The models were then built in two ways: without feature selection and with feature selection. The feature selection process was conducted by using a new Python library called Featurewiz. The performances of the models from the two operations were evaluated using three performance metrics, including accuracy, F1-score, and AUC (Area Under Curve) value from ROC (Receiver Operating Characteristics Curve). From the two operations, the results are similar in the way that tree-based models, especially those formed by the ensemble method, outperform the statistical models. Initially, in the process without feature selection, the champion model is XGBoost with 99.23% accuracy, while Random Forest ranks second with 98.79% accuracy. However, after the feature selection, the result reveals that the champion model is Random Forest. This model achieves an improvement of 0.66% in accuracy (99.45%), making it the best model from both operations. The model also scores 0.99 and 0.97 in F1-score and AUC values, respectively. The valuable insights gained from this study can serve as a comprehensive framework for machine learning applications in predicting thyroid illness. Additionally, the study highlights the advantageous utilization of the Python feature selection library, Featurewiz. With the combination of Featurewiz and machine learning applications, medical authorities can save time and reduce the risk of misdiagnosis when identifying patients with thyroid disease.
Automatically assessing student mastery and designing optimal stopping policies
Authors:   , Sapountzi Androniki
Published: May 2024

In this dissertation, I address some of the challenges of adaptive learning systems through the design of an assessment model. This model aims to estimate a student’s mastery level while determining the optimal length of the assessment tailored to the individual student. Such a task is not trivial. It raises four basic questions: 1. What has already been accomplished in the realm of models predicting future performance as learners interact with a sequence of exercises?, 2. How can student responses be translated into a mastery metric for a skill?, 3. What is the optimal number of questions to offer, striking a balance between avoiding overwhelming the learner and gathering the maximum amount of information about their mastery level?, and 4. How can one ensure that the assessment stops soon enough for a wide range of students’ performances, including those prone to ‘wheel-spinning’? In this dissertation, I delve into tackling these critical questions.