bluuebunny/crossref_metadata_2025 huggingface dataset:
СТАНОВЛЕННЯ Й РОЗВИТОК ПРАВОВОГО ПОЛЯ УКРАЇНИ ЩОДО ЗАХИСТУ ІНФОРМАЦІЙНОГО ПРОСТОРУ ДЕРЖАВИ
Authors: Глобенко Сергій
Published: December 2023

Наведено результати дослідження чинної нормативно-правової бази України, згідно з якою унормовано питання захисту інформаційного простору держави в умовах сьогодення. З’ясовано, що захист суверенітету, територіальної цілісності та національної безпеки є ключовими завданнями для будь-якої держави, у тому числі й України. Конкретизовано виклики й загрози у сферах інформаційної та кібербезпеки, зокрема щодо відсутності цілісної державної інформаційної політики. Встановлено, що у правовому полі України інформаційна безпека передбачає захист від зовнішніх впливів і дезінформації, що потребує спільних зусиль від залучених до процесу суб’єктів управління. Глобальні виклики, які стоять перед нашою державою, та відповідні стратегічні цілі спрямовані на забезпечення захисту національних інтересів та зміцнення суспільної стабільності. Підкреслено важливість здійснення низки пріоритетних заходів щодо забезпечення захисту кіберпростору в контексті гарантування національної безпеки. Наголошено на ризиках, нормативно закріплених пріоритетах та завданнях. Розглянуто загальний контекст зазначеної проблеми й актуалізовано важливість забезпечення кібербезпеки для національної безпеки, враховуючи сучасні виклики та загрози. Охарактеризовано основні складові національної системи стійкості, поєднання яких спрямовано на забезпечення національної безпеки України в умовах сучасних загроз, зокрема гібридних. З’ясовано, що внаслідок своєї комплексності мають враховуватися різні аспекти життєдіяльності суспільства і держави, в тому числі економічні, енергетичні, інформаційні, кібернетичні, екологічні, продовольчі, охорони здоров’я, освіти та культури тощо. Зазначено про важливість дотримання моральних та етичних норм під час створення й поширення медійного контенту з урахуванням обмежень для захисту національної безпеки та інформаційної безпеки держави. Встановлено необхідність уніфікації норм чинного правового поля задля створення єдиного інформаційного простору для забезпечення безпеки інформаційної взаємодії та зміцнення національної системи стійкості.
Population distribution and breeding practices of livestock in different districts of Bangladesh
Authors: Khandoker MAM Yahia , Ali Md Younus , Akter Tasmina , Akhtar Mst Mahomudha , Kona Mst Kamrunnahar , Meki Nusrat Jahan , Sompa Marzia Rahman , Meem Israt Jahan
Published: December 2023

The objectives of this study were to determine the farmers’ socio-economic characteristics, livestock population dynamics, and breeding practices followed by the farmers. Out of 1487 farmers, a major proportion (53.12%) of farmers was middle-aged. Most of the farmers (71.22%) were associated with agricultural activities and had low income per month (52.32%). Livestock keeping patterns of farmers were cattle, goats, buffalo, and combinations of these animals. Female animals were inferred to be more prevalent in different districts (cow 85.08%, doe 81.29%) than males (bull 14.92%, buck 18.71%). In case of cattle and goats, the highest number of farmers maintained a medium size herd, whereas buffalo farmers had a large herd size. In terms of breeding practices, the majority of the farmers (75.55%) performed artificial insemination (AI) in cattle and found it convenient to service their cows. When considering buffalo, and goat, the majority of the farmers (94.12% and 98.50%, respectively) practiced natural services. The findings also demonstrated that the majority of the farmers (73.8% and 82%, respectively) raised crossbreed cattle and buffalo, while just a tiny portion (26.18% and 18%, respectively) raised indigenous breeds. However, this situation was vice versa in case of goat. For choice of the breed according to the farmers, 39.17% of farmers preferred Black Bengal goat, 60.83% preferred cross breed.  This study represents a comprehensive overview of livestock status and existing breeding practices employed by the farmers in different districts of Bangladesh, which may be utilized to implement relevant livestock improvement programs in Bangladesh.
Asian Australas. J. Biosci. Biotechnol. 2023, 8(3), 38-48
Variations In The Genotypic And Phenotypic Characteristics Of Methicillin-Resistant Staphylococcus Aureus (Mrsa) From Students Attending Poultry Farms In Umuahia, Abia State, Nigeria
Authors: Ifediora AC , Enya E
Published: December 2023

Staphylococcus aureus causes significant epidemiologic and therapeutic challenges with various skin and soft tissue infections, the main forms of disease manifestation. The public health importance of this organism has been heightened by the emergence and spread of species that are resistant to treatment usually referred to as methicillin-resistant S. aureus (MRSA). This study was carried out to detect mecA and mecC genes in phenotypically determined MRSA isolates. Nasal swab samples of the subjects were cultured on mannitol salt agar and the isolates were identified as S. aureus using a combined morphological and biochemical characteristic. Antibiotic susceptibility profile was performed using the disk diffusion susceptibility method whilst phenotypic detection of MRSA isolates was by Cefoxitin disk diffusion method as per CLSI guidelines. Genomic DNA was extracted from the isolates using commercial kits. The extracted DNA was subjected to multiplex PCR to amplify the 163-bp and 188-bp fragment of the mecA and mecC genes respectively in a Pielter thermal cycler. The susceptibility pattern of MRSA isolates showed that the organisms were highly resistant to Augmentin 29 (93.5%), ceftazidime 18 (58.1%), Streptomycin 19 (76%) whilst high levels of susceptibility were seen for Ofloxacin 27 (87.1%), Levofloxacin 28 (90.3%), and Gentamicin 24 (77.4%). The antibiotic resistance profiles in MRSA isolates were recorded as follows: ciprofloxacin 6 (16.2%), Augmentin 32 (86.4%), erythromycin 13 (35.1%), Ceftazidime 22 (59.4%). Of the 10 MRSA isolates that were subjected to PCR, one isolate was found to harbor the 188-bp of mecC gene whilst mecA was absent from the screened isolates. The detection of mecC MRSA in the present study highlights the diagnostic importance of screening for mecC in mecA negative MRSA. We suggest that surveillance for MRSA should include screening for mecC gene where mecA is not detected in resistant isolates.
Stamford Journal of Microbiology, 2023. Vol. 13, Issue 1, p. 6-10
Occurrence of Carbapenem-Resistant Enterobacteriaceae (Cre) Abhorring Bla Imp, Bla Kpc And Bla Oxa-48 Genes Recovered From Ready -To- Dispose Poultry Wastes In Osogbo, Osun State
Authors: Oluwajide OO , Ademeso GM , Oladapo EO , Opatoro RI , Ponle ZO , Olumakinde TS , Oluokun TE , Ozabor PT , Olaitan JO
Published: December 2023

The uncontrolled use of antimicrobials in animal husbandry such as poultry for prophylaxis reasons is to increase output for monetary gains which have led to several acquired community infections with high mortality and morbidity rates. This study is however aimed at investigating the occurrence, prevalence, and molecular detection of carbapenemase genes of carbapenem-resistant Enterobacteriaceae (CRE) bacteria isolated from poultry liters in Osogbo, Osun State Nigeria. Twenty ready-to-pack poultry waste samples were plated for the isolation of Enterobacteriaceae on MacConkey and Brilliance Escherichia coli agar. Disc diffusion method was employed for screening carbapenem resistant isolates while resistant genes were detected using carbapenem resistant gene primers. Forty-six Enterobacteriaeceae were isolated namely: Kluyvera ascorbate (28.3%), Klebsiella oxytoca (10.9%), Citrobacter koseri (8.7%), Klebsiella aereogenes, Raoultell (Klebsiella) planticola, Serratia nematodipila (6.5%), Trabulsiella laguamensis, Salmonella spp. (diarizonae), Proteus vulgaris, Citrobacter farmeri (4.3%), of which Edwardsiella tarda, Providencia rustigianii, Citrobacter freundii, Enterobacter cloacae, Cedecea lapagei, Serratia liquefaciens and Dickeyachry santhemi was (2.2%) respectively. 52.2% of the isolates were carbapenem resistant while 92% of the CRE had bla IMP genes. Only one CRE (Trabulsiella guamensis) was positive to bla KPC gene while four 16.6% of the isolates namely: Citrobacter koseri, Raoultell (Klebsiella) planticola, Serratia nematodipila, Citrobacter freundiu and Citrobacter koseri were positive to blaOXA-48 gene. Therefore, this study infers the high prevalence of CRE isolates in poultry litters as a public health concern for the indiscrimate use of carbapenem.

Stamford Journal of Microbiology, 2023. Vol. 13, Issue 1, p. 15-20
Incidence of Antibiotic Resistant Escherichia Coli In UTI Suspected Patients-A Single Centered Study
Authors: Chakraborty SR , Shuvo MGS
Published: December 2023

The evaluation of antimicrobial sensitivity patterns has a significant role in prescribing antimicrobial drugs to treat patients suffering from urinary tract infections (UTIs). This study assessed the etiology and antimicrobial susceptibility of the common uropathogens as those were detected in Dhaka, Bangladesh. This study was conducted following the culture and identification of pathogenic microorganisms from patients of all age groups and sexes. A total of 110 urine samples were collected from suspected UTI patients for culture and sensitivity as advised by the physicians. Female patients (76.4%) were dominant over male patients (23.6%) and patients were 0 to 90 years of age. From these samples, 25 Escherichia coli were isolated from culture-positive cases to determine antibiotic sensitivity patterns. Most of these isolates were resistant to Azithromycin (100%), Nalidixic Acid (80%), Cotrimoxazole (54%), Ciprofloxacin (44%) and Cefixime (44%). The present study emphasized the necessity of standard microbiological screening techniques to evaluate the etiological characteristics required to effectively treat UTI patients.

Stamford Journal of Microbiology, 2023. Vol. 13, Issue 1, p. 21-24
Спеціалізація маркетингових досліджень в інноваційному розвитку глобальних компаній
Authors: Мних Ольга , Довгунь Оксана
Published: December 2023

В науковій роботі доведено, що процеси глобалізації та деглобалізації, вектори потоків критичних ресурсів, фінансового та інтелектульного капіталу повинні враховуватися при виборі напрямків досліджень маркетингових спеціалізованих компаній і в маркетинговій аналітиці підприємств, як учасників ринкових трансакцій, в їхній метричній системі координат для цілей зниження ринкової невизначеності та забезпечення умов для відтворення промислового капіталу. Попит на подібні дослідження корелює із зростанням цінності результатів маркетингових досліджень, як фактору виробництва та вагомого інтелектуального продукту в економіці знань. Виявлено тенденції  розвитку діяльності спеціалізованих компаній з маркетингових досліджень у 21 ст. і подано кількісну оцінку темпів росту їхнього доходу. Узагальнено, що глобальні інноваційно-активні компанії світу посилюють структурно-функціональну динаміку ринків та їх взаємодію, зокрема, на ринку автомобілебудування, що змінює вектор відносин В2В (business-to-business-B2B) – глобальних і локальних  гравців у їхніх мегапроектах. Доведено, що від  розуміння менеджерами цінності цифрової платформи для пошуку клієнтів  буде залежати швидкість перебудови бізнес-моделей підприємств та їх готовність до задоволення потреб суспільства у всіх сферах життєдіяльності. Аргументовано, що інноваційні інструменти і трансфер технологій з маркетингових досліджень  призводять до появи якісно нового комунікативного середовища, що включає різних представників для фінансування наукових досліджень та розробок (D&R), науковців та інституцій, які підтримують наукову діяльність, сферу бізнесу та суспільство. Доведено, що в умовах форс-мажорних обставин в Україні і в світі, коли час має важливу суспільну роль для вирішення нагальних соціальних проблем, зростає практичний інтерес до  вибору організаційно-правового формату відносин В2В. Узагальнено, що цифрові платформи стають фактором росту масштабу маркетингових досліджень з широкою участю зацікавлених сторін. Виявлено спільність методології дослідженння В2В та В2С при високих темпах цифровізації економіки та зростанні обсягів просування інноваційних інтелектуальних товарів і послуг, коли послаблюється вплив географічного чинника на диверсифікацію розвитку відносин «бізнес для бізнесу».
ENTRE ATOMIZACIÓN E INTERDISCIPLINA: EXPLORACIÓN DE NICHOS EMERGENTES EN LA INSERCIÓN DE DISEÑADORES INDUSTRIALES EN LOS ESCENARIOS DIGITALES
Authors: Rugo Martina
Published: December 2023

El presente artículo explora la adaptación de la profesión del diseño a un entorno dinámico caracterizado por la digitalización y la interdisciplinariedad. Se enfoca en el diseño de la experiencia del usuario (UX) como un ejemplo de integración de conocimientos en diversos campos del diseño, especialmente en productos digitales. Se reflexiona sobre la respuesta de la academia y la profesión a estos cambios, al subrayar la sinergia de conocimientos en los contextos digitales emergentes.En cuanto a la transformación de la profesión del diseño en respuesta a los avances tecnológicos y el trabajo remoto, se examina cómo los diseñadores han asumido roles interdisciplinarios y han cultivado habilidades para operar en entornos cambiantes. Además, se analiza la proliferación de especializaciones como el UX y la ampliación de los perfiles profesionales.

Como emergente del presente recorrido, se busca analizar y recorrer, desde el ejercicio profesional, su perspectiva y visibilizar la transformación y versatilidad de los diseñadores para adaptarse a las nuevas tecnologías. Esto se logra a través de recorrer el surgimiento de nuevas especializaciones en respuesta a las actuales dinámicas de profesionalización, en torno a las mismas.

Palabras clave: Interdisciplinariedad, escenarios digitales, atomización profesional, diseño UX, profesionalización.

AbstractThis article explores the adaptation of the design profession to a dynamic environment characterized by digitalization and interdisciplinarity. It focuses on user experience (UX) design as an example of knowledge integration in various fields of design, especially in digital products. The research reflects on the response of academia and the profession to these changes, highlighting the synergy of knowledge in emerging digital contexts.

Regarding the transformation of the design profession in response to technological advances and remote working, it examines how designers have assumed interdisciplinary roles and cultivated skills to operate in changing environments. In addition, it discusses the proliferation of specializations such as UX and the broadening of professional profiles.

As an emergent of the present journey, we will analyze and go through the professional practice and its perspective and make visible the transformation and versatility of designers to adapt to new technologies through the emergence of new specializations in response to the current dynamics of professionalization around them.

Keywords: Interdisciplinarity, digital scenarios, professional atomization, UX design, professionalization.
Türkiye’de Petrol Fiyatları ile Reel Döviz Kuru Arasındaki İlişki: Fourier Adl Eşbütünleşme Analizi
Authors: SİZER Lütfü
Published: December 2023

Bu çalışma, 2003:1-2023:6 dönemine ilişkin aylık verileri kullanarak Türkiye'de petrol fiyatları ile reel döviz kuru arasındaki uzun vadeli ilişkiyi incelemiştir. Değişkenler arasındaki uzun dönem ilişkisini incelemek için yapısal kırılmaların tarihi, sayısı ve biçiminden etkilenmediğinden Fourier temelli sınamalardan yararlanılmıştır. Değişkenler arasındaki ilişkiyi incelemek için Banerjee, Arčabić ve Lee, (2017) tarafından geliştirilen Fourier ADL eşbütünleşme testi uygulanmış ve değişkenlerin uzun dönemde beraber hareket ettikleri sonucuna ulaşılmıştır. Ayrıca uzun dönem katsayı tahmin sonuçlarına göre, döviz kuru ile petrol fiyatları arasında pozitif ve istatistiksel olarak anlamlı bir ilişkinin olduğu sonucuna ulaşılmıştır.
Sonography of Partial Tear of Distal Long Head of Biceps Tendon
Authors: Singh Amarjit
Published: December 2023

A 64-year-old female presents herself to the ED. Her chief complaint is left arm pain x 4 days, with hx of past injury. Ultrasound imaging confirmed a partial tear in the long head biceps tendon at the myotendinous junction.
FONTAN CIRCULATION AND PREGNANCY: IS IT POSSIBLE
Authors:   Surgery Department, Ruteng General Hospital, Manggarai Indonesia, Kusumaningrat Dorothea , Mustikaningrat Ellenora R ,   Obstetric and Gynecology Department, Ruteng General Hospital, Manggarai, Laksono Gerardo AK ,   Surgery Department, Ruteng General Hospital, Manggarai, Tahalele Paul L ,   Widya Mandala Surabaya Catholic University
Published: December 2023

More than 85% of congenital heart disease in children survive to adulthood according to recent advances in pediatric cardiology and heart surgery practice. Fifty percent of this population is made up of women, most of whom have reached child bearing age. In this group of patients, pregnancy represents a new challenge, whose natural history has been modified by surgery. In Fontan circulation, the ventricle unable to compensate for the major restriction in the bottleneck and non physiological suction have to pull blood through the lungs, although the ventricles provide the driving force for the circuit. Women with an adequate Fontan circulation can become pregnant without clinically significant long term sequele. Pre-marital and pre-pregnancy consultation is important. A close collaboration between cardiologist, obstetrician and anaesthesiologist is mandatory in order to get the best outcome of pregnancy.
Performing Mentorship in Collaborative Research Teams: Arts-Based Digital Encounters
Authors: Armos Nicole , Chasse Callista , Fels Lynn , Grindlay Marlies
Published: December 2023

Our research project explores mentorship in four studies located in Toronto, Montreal, Vancouver, and online. We questioned how and if performing mentorship in communal spaces created online could nurture and facilitate the levels of trust, vulnerability, security, and support we had experienced through in-person mentorship. We share the challenges we encountered as in-person research activities pivoted to online. We used online conferences, emails, a password-protected website, and notably, the creative practice of making and posting e-postcards, to foster an online mentoring community. Reflecting on our online practices and interactions, we come to theorize mentorship as performance – emergent, embodied, creative, and relational interactions in motion, creating and holding open spaces of possibility for one another in mentorship relationships.
Call for Submissions for Special Issue Focused on School Community Health and Wellness
Authors: CJAR
Published: December 2023

The Canadian Journal of Action Research (CJAR) and the Canadian Association of Action Research in Education (CAARE) invite manuscripts for a special themed issue that will focus upon school community health and wellness, and/or its related disciplines such as— but not limited to—physical education, health education, physical activity, sport, recreation, play, outdoor learning, social determinants of health, mental health literacy, and comprehensive school health/health promoting schools. Authors are encouraged to submit manuscripts that focus upon the application of action research related to any of these topic areas.
Full final manuscripts are due by December 15, 2023. Authors should indicate in their accompanying letter to the editor that they wish for their manuscript to be considered for publication in the School Community Health and Wellness Special Issue. The anticipated publication date is spring/summer 2024.
Please download the PDF for more information.
Formation and function of binucleated human hepatocytes
Authors:   , Darmasaputra Gabriella Sebastiani
Published: December 2023

Development of multicellular organisms, including humans, begins with one cell. Through many cell divisions and differentiations, this cell ultimately develops into an organism. All the information that is needed for the development of an organism is coded in its DNA and it is crucial that the DNA is passed on correctly to all cells. To protect the DNA during cell division, DNA is carefully packaged into X-shaped structures called chromosomes. Most human cells are diploid, which means they contain two sets of chromosomes. However, some cells accumulate more than two sets of chromosomes as part of their normal development. Cells that contain more than two sets of chromosomes are called polyploid cells. In humans, polyploid cells can be found in the liver, heart, mammary gland, and bone marrow.

Even though polyploid cells are found in many organs, we do not completely understand how and why they are formed. In this thesis, I present the results of our studies on the mechanism, regulation, and function of polyploid cells in diploid organisms, with a focus on human hepatocytes.

In Chapter 1, we present an overview of previous studies on the regulation and formation of polyploid cells during animal development. In addition to polyploid cells that are formed as part of normal development, polyploid cells can also arise due to errors in cell division or in response to organ damage. The parallels in the function of polyploidy in development and disease are reviewed in Chapter 2.

One of the ways in which polyploid cells are formed is through a process called endomitosis. In endomitosis, a cell replicates its DNA and package it into chromosomes as it would during a normal division; however, the cell does not physically divide in two, resulting in a polyploid cell that has twice the amount of DNA. How this process happens in human cells is not completely understood. In Chapter 3, we look into the mechanisms of endomitosis in human hepatocytes.

Apart from E2F proteins, not much is known about which other proteins regulate endomitosis. In Chapter 4, we use a CRISPR-based method to look for genes that promote endomitosis. This study identifies new candidate regulators of endomitosis, but a lot of work is still required to understand the role of these candidate regulators in the regulation of endomitosis.

Polyploid cells are often thought to have increased capacity for cellular processes, such as protein synthesis, but there are not many studies that have tested this hypothesis directly. In Chapter 5, we look at the effect of polyploidy towards cellular processes in human hepatocyte organoids and in the intestines of the nematode Caenorhabditis elegans, which represents an ideal model organism to study the effect of extreme polyploidy in a diploid organism.

Finally, in Chapter 6 we present how the results of our studies on polyploidy contribute to the field of developmental biology. The studies presented in this thesis represent one of the first steps on our journey to understand the mechanism and function of polyploidy.
An Investigation of the Impact of the High School Entrance Exam on the Teaching of English
Authors: KÜTÜK Seray İrem , AVARA Hayriye
Published: December 2023

English education programs are updated to keep up with the new trends and approaches. Curriculum designers introduce the changes into the curriculum. Since the teachers are expected to prepare students for the high-stakes exams, these exams are one of the problems that teachers face during their classes because of the preparation process. This study is therefore set out to determine the effects of high-school entrance exams on the implementation of the English curriculum. The methodological approach taken in this study is a mixed methodology based on the teachers’ views. 201 EFL teachers working at lower secondary schools filled the questionnaire regarding their in-class practices. Among the teachers, 10 teachers are interviewed by taking ample notes. To collect the quantitative data, web tools are utilized due to the vexatious process of Covid-19 days. The results of the study reveal that the high-school entrance test has negative effects regarding the approaches and methods employed in the classes. Furthermore, the classroom practices differ in different grades. The negative washback effects of high-stakes tests outweigh the positive ones in terms of the use of English language in a communicative way.
GeoGebra ile Yapılan İspat Çalışmalarının Öğretmen Adayları ve Öğretmenlerin Sözsüz İspat Yapma Becerileri Üzerine Etkililiğinin Karşılaştırılması
Authors: KURTULUŞ Fatma , YILDIZ Esra
Published: December 2023

Bu araştırma, dinamik geometri yazılımı GeoGebra ile ispat becerilerini geliştirmeye yönelik olarak tasarlanan eğitim programının, öğretmen ve öğretmen adaylarının sözsüz ispat edebilme becerileri üzerine etkililiğinin değerlendirilmesi amacıyla gerçekleştirilmiştir. Çalışmada nitel ve nicel çeşitli data toplama araçlarının kullanılmasından dolayı sıralı açıklayıcı yöntem kullanılmıştır. Yapılan araştırma 2019-2020 yılı Orta Karadeniz Bölgesinde seçilen ilin devlet üniversitesinde Matematik eğitimi okuyan 3.sınıf 35 öğretmen adayı ve Matematik Eğitiminde yüksek lisansta okuyan 6 matematik öğretmeni olmak üzere toplam 41 aday ile yapılmıştır. Katılımcılar ile beş haftalık GeoGebra sözsüz ispat becerilerini geliştirme eğitimi yapılmış ve gönüllü 9 katılımcı seçilerek çalışma grubu oluşturulmuştur. Araştırmanın verilerini, katılımcıların ispat beceri testine verdikleri cevaplar, GeoGebra eğitim sürecinde alınan kamera kayıtları, değerlendirme formları ve ses kayıtları alınarak yapılan görüşmeler oluşturmaktadır. Araştırmanın nicel bulguları sonucunda katılımcıların ön-testleri ile son-testleri arasında son-test lehine anlamlı bir farklılık tespit edilmiştir. Bu sebeple dinamik geometri yazılımı olan GeoGebra ile ispat becerilerini geliştirmeye yönelik olarak tasarlanan eğitim programının matematik öğretmeni ve öğretmen adaylarının sözsüz ispat becerilerinin gelişimini desteklediğini söylemek mümkündür. Ayrıca GeoGebra ile ispat becerilerini geliştirmeye yönelik olarak tasarlanan bu eğitim programının, matematik öğretmenlerinin ispat becerilerini öğretmen adaylarının ispat becerilerinden istatistiksel olarak anlamlı şekilde daha çok geliştirdiği sonucuna ulaşılmıştır.
Assessment of Micro-Gap in Hybrid Abutment-Crowns Fabricated with Different Materials
Authors: ÇETİN Tuğçe , ASLAN Yılmaz Umut
Published: December 2023

Objective: The aim of this in vitro study is to evaluate the micro-gap changes in three dimensions after thermodynamic loading between hybrid abutment crowns made of different materials and implants with internal conical connection.

Methods: A total of 10 morse cone connection implants (Straumann Bone Level Implant, Institut Straumann AG, Basel, Switzerland) were used. In this study, two study groups were formed using lithium disilicate glass-ceramic (LD) and polymethyl methacrylate (PMMA) in hybrid abutment-crown production (n=5). Hybrid abutment-crowns were fabricated by CAD/CAM system. Hybrid abutment crowns were designed and manufactured digitally. A 4-month of clinical cycle was applied to the samples in the chewing simulator. The micro-gap at the implant- abutment interface was visualized with micro-CT before and after thermodynamic loading. Micro-gap change was determined using these obtained images. For comparisons, independent t-test was used.

Results: When comparing the micro-gap volumes before and after aging, no significant difference was observed between the LD and PMMA groups. The micro-gap increase after loading was 0.68 ±0.209 in the LD group and 0.45 ±0.373 in the PMMA group. Although the increase was higher in the LD group, there is no statistically significant difference between two groups.

Conclusion: he micro-gap in the interface of implants and hybrid abutment crowns increased after aging. Hybrid abutment-crown material affected the micro-gap increase, but it was not statistically significant.
Desenvolvimento inicial da cratylia argentea em diferentes consórcios, Nova Xavantina - MT
Authors: Neves Vitor Hugo Silva , Maia Ana Heloisa , Lima Alana Umbelino
Published: December 2023

A Cratylia argentea é uma espécie nativa de áreas do cerrado que apresenta características relevantes, como boa cobertura do solo, fixação de nitrogênio aumenta de fertilidade, reestruturação e descompactação do solo, com grande potencial para consórcios com outras plantas. O presente trabalho tem como objetivo avaliar o desenvolvimento inicial da C. argentea em função de diferentes consórcios, em Nova Xavantina-MT. O experimento foi realizado na Unidade Demonstrativa de Cultivo Agroecológico, do Núcleo de Estudos, Pesquisa e Extensão em Agroecologia (NEPEA) localizada na fazenda experimental do Campus da Unemat Nova Xavantina sendo conduzido em delineamento inteiramente casualizado, com cinco (5) tratamentos e quatro (4) repetições, cuja parcela útil foi constituída das 10 plantas centrais. Os tratamentos utilizados foram: T1: testemunha (C. argentea - solteira), T2: C. argentea + Sesamum indicum- gergelim, T3: C. argentea + Canavalia ensiformis - feijão de porco, T4: C. argentea + Cajanus cajan- feijão guandu; T5: C. argentea + Crotalaria pectabiliscrotalária. O cultivo isolado da Cratylia argentea apresentou os maiores valores para os parâmetros de crescimento e produção de fitomassa, a partir dos 60 DAP, o que garantiu a adaptação da espécie às condições de Nova Xavantina-MT. Nenhum dos consórcios avaliados neste período, favoreceram o melhor crescimento e desenvolvimento da C. argentea, embora os resultados encontrados no presente trabalho, reforcem a potencialidade da C. argentea em cultivo solteiro, não se descarta a possibilidade de outros estudos, avaliando diferentes consórcios e espaçamentos para compreensão do desenvolvimento da espécie.
Conhecimento dos agentes comunitários de saúde sobre o acidente vascular cerebral: relato de experiência
Authors: Gasparini Gabriela Ferreira , Barbosa Talita Souza , Neves Igor Fernando , Covre Eduardo Rocha , Silveira Andressa Rocha da
Published: December 2023

O acidente vascular cerebral é a morte do tecido cerebral, que ocasiona uma obstrução na artéria, resultando na incapacidade de transportar oxigênio e sangue ao cérebro, apresentando sinais e sintomas visíveis. O objetivo deste relato de experiência é identificar o conhecimento dos Agentes Comunitários de Saúde (ACS) referente aos sinais e sintomas do Acidente Vascular Cerebral (AVC). As informações foram coletadas em uma Unidade Básica de Saúde (UBS) durante um estágio supervisionado obrigatório com agentes comunitários de saúde. Os agentes comunitários de saúde participantes foram convidados a responder perguntas relacionadas aos conhecimentos deles sobre sinais e sintomas do AVC. Como principais resultados dessa pesquisa temos em sua maior parte entrevistados do sexo feminino e em sua maioria na faixa etária de 35 anos. Após a aplicação do questionário, foi observado que o conhecimento dos profissionais Agentes Comunitários de Saúde (ACS) é relativamente bom, já que precisamos levar em consideração a limitação que esses profissionais têm do acesso a esse tipo de informações sobre o Acidente Vascular Cerebral (AVC) e seus sinais e sintomas.
Краниосерии современных малоголовых популяций экваториального пояса Старого Света
Authors: Пестряков А. , Григорьева О. , Ю. Рашковская (Пеленицына)
Published: December 2023

Авторами исследовались взятые из антропологической литературы среднесерийные данные 15 краниосерий (только мужские фракции) популяций экваториальной расы Старого Света, отличающиеся малой величиной черепной коробки, общая ростовая величина (ОРВ) которых не превышает 261,0, за исключением одной серии аэта, видимо имеющей смешанное с тагалами происхождение. В их число попали следующие группы: пигмеи (3 серии), земледельцы банту (2 серии), папуасы Новой Гвинеи (4 серии), меланезийцы (2 серии), андаманцы (2 серии), аэта (2 серии). В этих сериях фиксировались среднегрупповые величины следующих метрических параметров черепной коробки: наибольшие продольный, поперечный и высотный (от базиона) диаметры; черепной, высотно-продольный и высотно-поперечный указатели; указатели долихоидности (УД), брахиоидности (УБ), гипсиоидности (УГ) и степень сферичности черепной коробки (СС). Так как верхний предел общей величины черепной коробки (ОРВ) был ограничен, как следует из названия статьи, то в рассчитанной дендрограмме таксономического различия этих краниосерий учитывались лишь параметры формы черепной коробки. Дендрограмма разбилась на два кластера. В первом оказались все африканские краниосерии и папуасы. Во втором — краниосерии андаманцев, аэта и меланезийцев. Краниосерии первого кластера по форме черепной коробки соответствуют панойкуменному краниотипу тропидов и названы авторами микротропидами. Краниосерии второго кластера по форме черепной коробки напоминают локальный краниотип сундидов и названы микросундидами. Эти два краниотипа сильно различаются по форме черепной коробки и имеют различный генезис. Их объединяет лишь малая величина черепа.

The authors studied 15 published mean sample data (only male samples) on the equatorial Old World populations, which are characterized by small crania with the total growth value no more than 261,0 except for the Aeta sample, which probably has some Tagal admixture. The studied samples represented the following groups: Pygmies (3 samples), Bantu agriculturalists (2 samples), Papuans of New Guinea (4 samples), Melanesians (2 samples), Andamans (2 samples), Aeta (2 samples). The analysis included three Martin’s cranial measurements (1, 8, 17) and three indices (1/8, 17/8, 17/1) as well as four variables designed by one of the authors. Only the shape parameters of the cranium were used to calculate the dendrogram of the taxonomic differences of these cranial samples. The dendrogram identified two clusters. The first one included all the African samples and Papuans, the second one — Andamans, Aeta and Melanesians. The samples of the first cluster correspond to the Tropid craniotype can be called Microtropids. Samples of the second cluster resemble the Sundid craniotype can be called Microsundids. These two craniotypes differ greatly in the shape of the cranium and have different origins; they are only similar in the small size of the skull.
In vivo knee biomechanics during badminton lunges at different distances and different foot positions by using the dual fluoroscopic imaging system
Authors: Peng Di , Mao Zheng , Zhang Wang , Yu Jinglun , Zhang Shengnian
Published: December 2023

Background: Lunges are common in badminton. Distance and foot position affect knee joint loadings under lunges, which are closely related to knee injury incidence. Investigations involving dynamic knee motion in vivo, kinetics, and muscle activation in lunges, especially during lunges of different distances and foot positions, are instrumental for understanding knee performance and injury risks of players.

Methods: A total of 10 experienced badminton athletes (10 females; height, 164.5 ± 5.0 cm; weight, 59.3 ± 6.0 kg; and age, 22 ± 1.0 years) were recruited. By using a high-speed dual fluoroscopic imaging system, Qualisys motion capture system, Kistler force plate, and Delsys electromyography simultaneously, data were collected during players’ 1.5 times leg length lunge, the maximum lunge, and the maximum lunge while the foot rotated externally. Magnetic resonance and dual fluoroscopic imaging techniques were used to analyze the in vivo knee kinematics.

Results: Compared with the 1.5 times leg length lunge, knee flexion for the maximum lunge increased significantly (p < 0.05). The anterior–posterior ground reaction force (GRF) and vertical GRF of the maximum lunge were significantly higher than those of the 1.5 times leg length lunge. During the two different foot position lunges with the maximum distance, the posterior translation of knee joint was larger (p < 0.05) when the foot rotated externally than the normal maximum lunge. Moreover, the anterior–posterior GRF and vertical GRF increased significantly when the foot rotated externally. Significant differences were observed in valgus–varus rotation torque and internal–external rotation torque of the knee joint under the two distance lunges and two foot position lunges (p < 0.05). No significant difference was found in knee muscle activation during the two distance lunges and during the two foot position lunges.

Conclusion: High knee torque and compressive loadings with increasing lunge distance may cause knee injuries in badminton. When lunging in the external foot rotation under the maximum distance, high quadriceps force and posterior tibia translation force could result in knee injuries among badminton players.
The relationship between the oblique sagittal temporomandibular joint disc position and the volume surface area of the condyle in young TMD adults
Authors: Gao Yudong , Luo Dan , Yuan Mujie , Yang Yanhao , Xu Zexian , Yang Jianjun
Published: December 2023

The present study aims to compare the volume surface area of the condyle, the horizontal condylar axial angle and the disc-condyle angle between temporomandibular disorder (TMD) and asymptomatic volunteers, explore and analyze the relationship between the temporomandibular joint (TMJ) disc position in oblique sagittal plane and the volume surface area of the condyle in young adults with TMD symptoms. 84 young adult volunteers were received TMJ examination by Magnetic Resonance Imaging (MRI) and Cone Beam Computed Tomography (CBCT). TMD and asymptomatic volunteers were 42 each. MRI was used to assess the position of TMJ disc in the oblique sagittal plane with the condyle apex method. CBCT data were used for three-dimensional (3D) reconstruction of condyle and the measurements of the horizontal condylar axial angle and the volume surface area of the condyle. The condylar volume surface area of the TMD group was smaller than that of the asymptomatic group (p < 0.05), the disc condyle angle was larger than that of the asymptomatic group (p < 0.05), and no significant difference was found in the horizontal condylar axial angle (p > 0.05). In terms of correlation, the volume surface area of the condyle were negatively correlated with the position of the articular disc in TMD patients (p < 0.05). This significant negative correlation suggests that the possibility of disc displacement can be considered when poor condylar morphology is found.
Gamete-exporting organs of vertebrates: dazed and confused
Authors: Kanamori Akira , Kobayashi Yasuhisa
Published: December 2023

Mature gametes are transported externally for fertilization. In vertebrates, the gonads are located within the coelom. Consequently, each species has specific organs for export, which often vary according to sex. In most vertebrates, sperm ducts and oviducts develop from the Wolffian and Müllerian ducts, respectively. However, exceptions exist. Both sexes of cyclostomes, as well as females of basal teleosts, lack genital ducts but possess genital pores. In teleosts of both sexes, genital ducts are formed through the posterior extensions of gonads. These structures appear to be independent of both Wolffian and Müllerian ducts. Furthermore, the development of Wolffian and Müllerian ducts differs significantly among various vertebrates. Are these gamete-exporting organs homologous or not? A question extensively debated around the turn of the 20th century but now largely overlooked. Recent research has revealed the indispensable role of Wnt4a in genital duct development in both sexes of teleosts: zebrafish and medaka. wnt4a is an ortholog of mammalian Wnt4, which has functions in Müllerian duct formation. These results suggest a potential homology between the mammalian Müllerian ducts and genital ducts in teleosts. To investigate the homology of gamete-exporting organs in vertebrates, more detailed descriptions of their development across vertebrates, using modern cellular and genetic tools, are needed. Therefore, this review summarizes existing knowledge and unresolved questions on the structure and development of gamete-exporting organs in diverse vertebrate groups. This also underscores the need for comprehensive studies, particularly on cyclostomes, cartilaginous fishes, basal ray-finned fishes, and teleosts.
The preliminary evidence on the association of the gut microbiota with stroke risk stratification in South Chinese population
Authors: Huang Haiyan , Kuang Zhuoran , Mo Ruibi , Meng Miaomiao , Cai Yefeng , Ni Xiaojia
Published: December 2023

Aims

This study aimed to investigate the association between the gut microbiota and the risk of stroke.

Methods

Faecal samples from 60 participants in South China, including 45 individuals with risk factors for stroke and 15 healthy controls, were collected and subjected to 16S rRNA sequencing. A bioinformatics analysis was performed to characterise the gut microbial diversity and taxonomic compositions at different risk levels (low, moderate, and high) of stroke. Functional prediction and correlation analyses between the microbiota and laboratory markers were performed to explore the potential mechanisms.

Results

A significant difference in beta diversity was observed between the participants from the stroke risk and healthy control groups. Linear discriminant effect size analysis revealed a large number of vascular beneficial bacteria enriched in the participants from the healthy control and low-risk groups, but a few vascular harmful bacteria were more abundant in the participants from the high-risk group than in those from the other groups. In addition, Anaerostipes, Clostridium_XlVb, and Flavonifractor, all of which belonged to the Firmicutes phylum, were enriched in the participants from the low-risk group, and their relative abundances gradually decreased as the stroke risk increased. Spearman’s analysis revealed that these outstanding microbiota correlated with the levels of triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, white blood cells, neutrophils, and carotid intima-media thickness.

Conclusion

The preliminary evidence suggests that gut microbiota is associated with stroke risk. It potentially ameliorates atherosclerosis by targeting lipid metabolism and inflammation. This provides novel insights into the early screening of stroke risk and primary prevention.
Postoperative hypernatremia is associated with worse brain injuries on EEG and MRI following pediatric cardiac surgery
Authors: Lin Rouyi , Du Na , Feng Jinqing , Li Jianbin , Li Xiaowei , Cui Yanqin , Ning Shuyao , Zhang Mingjie , Huang Guodong , Wang Huaizhen , Chen Xinxin , Ma Li , Li Jia
Published: December 2023

Objectives

Dysnatremia is a common electrolyte disturbance after cardiopulmonary bypass (CPB) surgery for congenital heart disease (CHD) and a known risk factor for adverse neurological events and clinical outcomes. The objective of this study was to evaluate the association of dysnatremia with worse abnormal EEG patterns, brain injuries detected by magnetic resonance imaging (MRI) and early adverse outcomes.

Methods

We monitored continuous EEG in 340 children during the initial 48 h following cardiac surgery. Demographics and clinical characteristics were recorded. Sodium concentrations were measured in the arterial blood gas analysis every 6 h. Hyponatremia and hypernatremia were classified by the average of sodium concentrations over 48 h. Postoperative cerebral MRI was performed before hospital discharge.

Results

In our patient cohort, dysnatremia was present in 46 (13.5%) patients. Among them, hyponatremia occurred in 21 (6.2%) and hypernatremia in 25 (7.4%). When compared to patients with normonatremia, hyponatremia was not associated with EEG abnormalities and early adverse outcomes (Ps ≥ .14). In hypernatremia group, the CPB time was significantly longer and more frequent use of DHCA (Ps ≤ .049). After adjusting for time, CPB time and the use of DHCA, hypernatremia was significantly associated with worse EEG abnormalities (including background, seizures and pathological delta brushes), more severe brain injuries on MRI (Ps ≤ .04) and trended to be associated with longer postoperative mechanical ventilation time (P = .06).

Conclusion

Hypernatremia and hyponatremia were common in children after cardiac surgery. Hypernatremia, but not hyponatremia, was significantly associated with worse EEG abnormalities and more severe brain injuries on MRI and extended postoperative mechanical ventilation time.
Training in the art and science of facilitation to scale research mentor training in low and middle income countries
Authors: Goldberg Bennett B. , Mbugi Erasto V. , Kyari Fatima , Woods Sara E. , Balandya Emmanuel , Drane Denise , Reng Rifkatu , Kakoko Deodatus
Published: December 2023

Advancing biomedical research in low and middle income countries (LMICs) to expand the capacity for LMICs to integrate biomedical research into their health care systems and education has been the focus of many programs in global health over the past two decades. Central to the success of these programs is effective research mentoring, characterized by academic, career and psychosocial support through culturally appropriate practices. Research mentoring is a learned skill, developed through training, mutual discussions, practice and feedback. The majority of extant training programs are designed and delivered by US partners, so the next stage in building capacity is to train facilitators within the LMIC partner institutions to contextualize and advance mentoring specifically within their cultural and institutional norms by co-developing, delivering and evaluating semi-annual research mentoring training. To this end, we describe the development, delivery and outcome evaluation of a 5-week course in the art and skill of facilitation. Care was taken to explicitly distinguish between concepts of “teaching” and “facilitation,” since “teaching” is closely connected to a transmission or banking model of education, which is characterized by “top-down,” hierarchical relationship. The course discussed power and positionality, themes that resonate with partners in Nigeria and Tanzania. These themes provided unique entry into deeper conversations core to advancing mentoring practice away from the traditional dyadic power structure that remains from colonization. Evaluation findings indicate significant advances in awareness of differences between teaching and facilitating, increased confidence in facilitation skills, especially in the area of structured planning and organization, as well as improved communication and interpersonal skills. All respondents felt that students in Nigeria and Tanzania would respond well to the facilitation approach conveyed during the course and they found value in participating in the course as a cohort.
A new e-health cloud-based system for cardiovascular risk assessment
Authors: Tatsis G. , Baldoumas G. , Christofilakis V. , Kostarakis P. , Varotsos P. A. , Sarlis N. V. , Skordas E. S. , Bechlioulis A. , Michalis L. K. , Naka K. K.
Published: December 2023

Sudden cardiac death (SCD) is one of the leading causes of death worldwide. Many individuals have no cardiovascular symptoms before the SCD event. As a result, the ability to identify the risk before such an event is extremely limited. Timely and accurate prediction of SCD using new electronic technologies is greatly needed. In this work, a new innovative e-health cloud-based system is presented that allows a stratification of SCD risk based on the method of natural time entropy variability analysis. This innovative, non-invasive system can be used easily in any setting. The e-health cloud-based system was evaluated using data from a total of 203 individuals, patients with chronic heart failure (CHF) who are at high risk of SCD and age-matched healthy controls. Statistical analysis was performed in two-time windows of different duration; the first-time window had a duration of 20 min, while the second was 10 min. Employing modern methods of machine learning, classifiers for the discrimination of CHF patients from the healthy controls were obtained for the first as well as the second (half-time) window. The results indicated a very good separation between the two groups, even from samples taken in a 10-min time window. Larger studies are needed to further validate this novel e-health cloud-based system before its use in everyday clinical practice.