bluuebunny/crossref_metadata_2025 huggingface dataset:
The Broken “Ring of Fire”: A New Radiological Sign as Predictor of Syndesmosis Injury?
Authors: Calder James , Mitchell Adam , Lomax Adam , Ballal Moez S. , Grice John , van Dijk Niek , Lee Justin
Published: March 2017

Background:

Subcircumferential periosteal edema above the ankle joint is frequently present on magnetic resonance imaging (MRI) with syndesmosis injuries but has not been previously reported. Fluid height within the interosseous membrane also has not previously been shown to be associated with syndesmosis injury severity.

Purpose:

To investigate whether a new sign on MRI and measurement of the length of fluid within the interosseous membrane above the ankle may be used to enable identification of a syndesmosis injury and allow differentiation from lateral ligament injury.

Study Design:

Cohort study (diagnosis); Level of evidence, 3.

Methods:

Three groups of patients (those with an isolated syndesmosis injury [SI group], isolated lateral ligament injury [LLI group], and no injury [NI group]) who had an ankle MRI for another reason were identified from a patient notes database and the MRI scans retrieved. The scans were anonymized and independently assessed by 8 clinicians (surgeons and radiologists) who were blinded to the diagnosis. The maximum length of fluid above the ankle within the intraosseous membrane was measured for each patient. The presence or absence of distal anterior, lateral, and posterior tibial periosteal edema was recorded (broken “ring of fire”).

Results:

Measurement of the length of fluid above the ankle had excellent intraobserver reliability (intraclass correlation coefficient, 0.97; 95% CI, 0.93-0.99) but poor interobserver reliability. Fluid extended higher in both the LLI group ( P = .0043) and SI group ( P = .0058) than the NI group, but there was no significant difference between the LLI and SI groups ( P = .3735), indicating that this measurement cannot differentiate between the injuries. The presence of the broken “ring of fire” around the distal tibia was significantly more frequent in the SI group when compared with both LLI and NI groups ( P < .00001). The sensitivity of this sign is 49%, but when present, this sign has a 98% specificity for syndesmosis injury.

Conclusion:

The presence of tibial subcircumferential periosteal edema 4 to 6 cm above the ankle joint (the “ring of fire”) is highly suggestive of a syndesmosis injury. This new radiological sign can assist with early identification of such injuries. The measurement of height of fluid above the ankle within the interosseous membrane is variable and cannot differentiate severe ankle sprains from high ankle sprains involving the syndesmosis.
Understanding Preferences for Treatment After Hypothetical First-Time Anterior Shoulder Dislocation: Surveying an Online Panel Utilizing a Novel Shared Decision-Making Tool
Authors: Streufert Ben , Reed Shelby D. , Orlando Lori A. , Taylor Dean C. , Huber Joel C. , Mather Richard C.
Published: March 2017

Background:

Although surgical management of a first-time anterior shoulder dislocation (FTASD) can reduce the risk of recurrent dislocation, other treatment characteristics, costs, and outcomes are important to patients considering treatment options. While patient preferences, such as those elicited by conjoint analysis, have been shown to be important in medical decision-making, the magnitudes or effects of patient preferences in treating an FTASD are unknown.

Purpose:

To test a novel shared decision-making tool after sustained FTASD. Specifically measured were the following: (1) importance of aspects of operative versus nonoperative treatment, (2) respondents’ agreement with results generated by the tool, (3) willingness to share these results with physicians, and (4) association of results with choice of treatment after FTASD.

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

A tool was designed and tested using members of Amazon Mechanical Turk, an online panel. The tool included an adaptive conjoint analysis exercise, a method to understand individuals’ perceived importance of the following attributes of treatment: (1) chance of recurrent dislocation, (2) cost, (3) short-term limits on shoulder motion, (4) limits on participation in high-risk activities, and (5) duration of physical therapy. Respondents then chose between operative and nonoperative treatment for hypothetical shoulder dislocation.

Results:

Overall, 374 of 501 (75%) respondents met the inclusion criteria, of which most were young, active males; one-third reported prior dislocation. From the conjoint analysis, the importance of recurrent dislocation and cost of treatment were the most important attributes. A substantial majority agreed with the tool’s ability to generate representative preferences and indicated that they would share these preferences with their physician. Importance of recurrence proved significantly predictive of respondents’ treatment choices, independent of sex or age; however, activity level was important to previous dislocators. A total of 125 (55%) males and 33 (23%) females chose surgery after FTASD, as did 37% of previous dislocators compared with 45% of nondislocators.

Conclusion:

When given thorough information about the risks and benefits, respondents had strong preferences for operative treatment after an FTASD. Respondents agreed with the survey results and wanted to share the information with providers. Recurrence was the most important attribute and played a role in decisions about treatment.
Teaching Critical Thinking in Graduate Medical Education: Lessons Learned in Diagnostic Radiology
Authors: Morrissey Benjamin , Heilbrun Marta E
Published: March 2017

The 2014 Institute of Medicine report, Graduate Medical Education that Meets the Nation’s Health Needs, challenged the current graduate medical training process and encouraged new opportunities to redefine the fundamental skills and abilities of the physician workforce. This workforce should be skilled in critically evaluating the current systems to improve care delivery and health. To meet these goals, current challenges, motivations, and educational models at the medical school and graduate medical education levels related to formal training in nonclinical aspects of medicine, especially critical thinking, are reviewed. Our diagnostic radiology training program is presented as a “case study” to frame the review.
Use of variothermal heating for the extrusion embossing of microstructured poly(methylmethacrylate) and polycarbonate optical films
Authors: Hopmann Christian , Petzinka Florian
Published: March 2017

The importance of microstructured parts and extrudates is rising because of the increasing functional integration in many different fields of application, for example in the automotive industry and medical technology. Variothermal extrusion embossing is a continuous process that combines plastic film production with the application of large-area microstructures. The process utilizes an embossing roll and an external heating device to continuously imprint the desired structure into film during extrusion. Through this microstructuring, it is possible to integrate innovative functions into a film. Present efforts are focused on forming optical structures (micro-optics) on polycarbonate and poly(methylmethacrylate) films. This article deals with process control requirements that are necessary to successfully apply this technology, and also demonstrate how, through suitable process parameter selection, high-quality microstructures can be effectively embossed on the films. Different microstructures between 24 and 165 µm in height and between 100 and 200 µm in width are tested. With poly(methylmethacrylate) better microstructure reproduction could be achieved than with polycarbonate.
Identity versus Citizenship: Transformations in the Discourses and Practices of Citizenship
Authors: Purvis Trevor , Hunt Alan
Published: March 2017

The recent surge of theoretical interest in citizenship has been shaped in important ways by a growing sensitivity to the politics of identity. Citizenship, conceived as a matrix of rights and obligations governing the members of a political community, exists in tension with the heterogeneity of social life and the multiple identities that arise therefrom. This tension expresses itself in the clash between the 'universal' citizen and numerous dispersed identities of which citizenship is but one. Citizens share the rights and obligations arising from that status, and the concept of 'equality' arising from this shared status has very real implications for the politics of identity, since citizenship has traditionally claimed priority over other identities. In practice this has often resulted in the relegation of alternative identities to an extra-political or even pre-political status. Today these alternative identities have become overtly politicized and as a result the stability of the identity of 'citizen' has itself been destabilized and contested. The 'rise' of identity politics has thus ushered in a number of challenges to, and transformations in, the discourses of citizenship. In this article we bring the resource of governmentality theory to bear upon the changing conditions of a modern complex citizenship that is not confined to the political arena, and a conception of politics not confined to the state. To this is added a neo-Gramscian consideration of counter-hegemony. This yields an agonistic vision of citizenship in which universal elements are not imposed from above, but are the outcome of projects in which social forces change themselves in constituting alliances with other political identities.
Getting Public Law Back into a Critical Condition: The Rule of Law as a Source for Immanent Critique
Authors: Pearson Geoff , Salter Michael
Published: March 2017

This article explores a series of issues that arise in relation to the methodology of conducting a critique of legal ideologies. It addresses the attempt by the Sheffield School of public law to formulate and apply an 'immanent' model of critique that builds upon the position developed by the Frankfurt School of critical social theory. We address difficulties that arise with the Sheffield School's interpretation of this model of critique, not least the problems with its attempt to apply a clear-cut distinction between wholly internal, immanent and external modes of critique. Our overall aim is to formulate a more adequate model of ideology critique that is able to overcome the various difficulties we have discovered within the Sheffield School's model. We argue that this can be achieved without relapsing back into the no less serious contradictions which can arise with external modes of critique. These merely superimpose ready-made criteria of assessment upon the object of their analysis, without first establishing their appropriateness.
Perverse Criminologies: The Closet of Doctor Lombroso
Authors: Groombridge Nic
Published: March 2017

This article argues for the importance of (homo)sexuality to the criminological enterprise. It traces a course of criminological engagement with homosexuality from the works of Lombroso and the early sexologists, through the 'nuts, sluts and perverts' period of interactionism to gay activism and polemic against homophobic violence and discrimination. Criminology is seen to have lumped both the 'criminal' and the 'homosexual' together in its early manifestation before ceding its interest to medicine and the law. In criminology's mid-period, homosexuality is taken up again as part of the interactionist 'sociology of deviance' project before it is dropped again by radicals more interested in the politics of class and race. Currently in criminology sexuality is slowly being granted to women (the young and black were - sometimes jealously? - assumed to have it already) and homosexuality is increasingly admitted to the list of victims of crime. What might be the scope within criminology for gay empiricism, standpointism or 'queer theory'? Moreover, what might this mean for the 'masculinity' turn in some recent criminology?
Compliance Construction in the Context of Environmental Regulation
Authors: Lange Bettina
Published: March 2017

This article explores compliance in the context of environmental regulation. It rejects a formal concept of compliance according to which statements about compliance can be made by assessing a self-contained notion of social practices of the regulated in the light of formal legal rules. Linked to this type of analysis is the notion of a 'gap' between formal legal requirements and what the regulated do in practice. In examining this perspective critically the article argues that the concepts of rules and social practices have to be seen not as self-contained categories but as closely linked. These close links are created both on a level of behaviour, through what the regulators and the regulated actually do in practice, and on a level of meaning of rules. Thus the notion of a 'gap' needs to be complemented through a concept of integration between rules and social practices. The article develops this argument by drawing first on literature on enforcement, discretion and creative compliance; and second by relying on qualitative empirical data on the implementation of a waste management site licence by staff at a waste treatment plant and the enforcement activities of waste control officers.
Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice
Authors: Mukhopadhyay Subhradip , Antalis Toni M. , Nguyen Khanh P. , Hoofnagle Mark H. , Sarkar Rajabrata
Published: March 2017

Key Points

Endogenous p53 within myeloid cells regulates venous thrombus resolution, intrathrombus macrophage polarization, and fibrosis. The p53 agonist quinacrine accelerates resolution of established venous thrombus, a potential translational benefit in patients with DVT.
A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety
Authors: Mao Jie , Liu Shujun , Ai Min , Wang Zhuo , Wang Duowei , Li Xianjing , Hu Kaiyong , Gao Xinghua , Yang Yong
Published: March 2017

Melittin is the main effective component of bee venom and has extensive biological functions; however, serious side effects have restricted its clinical application. Preclinical and clinical studies showed that the main adverse events were allergic reaction and pain at the administration site. To decrease the toxicity, we prepared melittin nano-liposomes by encapsulating melittin with poloxamer 188 and explored the inhibitory activities on liver cancer together with biological safety. Here, we showed that melittin nano-liposomes significantly inhibited the survival of hepatocellular carcinoma (HCC) cells in vitro and prominently suppressed the growth of subcutaneous and orthotopic HCC transplantation tumors in vivo. It was important that it induced less inflammation and allergy in mice compared with melittin. Overall, melittin nano-liposomes would have a better application in HCC therapy due to its significant anti-tumor activity and better biological safety.
Antiarrhythmic drugs for out-of-hospital cardiac arrest with refractory ventricular fibrillation
Authors: Tagami Takashi , Yasunaga Hideo , Yokota Hiroyuki
Published: March 2017

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.
Mechanical ventilation in obese ICU patients: from intubation to extubation
Authors: De Jong Audrey , Chanques Gerald , Jaber Samir
Published: March 2017

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.
Novel insights in ICU-acquired respiratory muscle dysfunction: implications for clinical care
Authors: Jonkman Annemijn H. , Jansen Diana , Heunks Leo M. A.
Published: March 2017

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.
Antioxidant properties of the carotenoid extracts of three Deinococcus–Thermus phylum bacteria, Meiothermus sp. strains RP and TP and Thermus sp. strain YY from Paniphala hot spring, India
Authors: Mukherjee Trinetra , Bose Sucharita , Mukhopadhyay Subhra Kanti
Published: March 2017

Background

The purpose of the study was to extract carotenoids from thermophilic bacteria which show efficient antioxidant and protein oxidation inhibition properties, characterize and identify those isolates, extract the carotenoids in different solvents, quantify the carotenoids and perform concentration-dependent and solvent-dependent quantitative assays validated and analysed by appropriate statistical tests.

Methods

Three pigment-forming thermophilic strains were isolated from water sample of Paniphala hot spring, India, and tentatively identified by 16S ribosomal DNA (rDNA) homology. Different concentrations of the carotenoid extracts (100, 80, 40 and 20 μg) in three solvents, methanol, DMSO and water, were used to determine the antioxidant activity through five methods: the DPPH (1,1-diphenyl-2-picrylhydrazyl) assay, the ABTS (2,2-azino-bis (3-ethylbenz-thiazoline-6-sulfonic acid)) assay, the hydrogen peroxide assay, TOC (total antioxidant capacity) assay and inhibition of protein oxidation assay. Statistical analysis of mean, standard deviation, ANOVA and Pearson correlation coefficient was performed in Microsoft Excel statistical package.

Results

The isolates were tentatively identified as Meiothermus sp. strain RP, Meiothermus sp. strain TP and Thermus strain YY. Meiothermus sp. formed red coloured pigment, whereas Thermus sp. formed yellow coloured pigment. All of the extracts showed positive results in DPPH assay, ABTS assay and hydrogen peroxide radical scavenging assay with best results obtained when the extracts were dissolved in water. Total antioxidant capacity assay was also high in all the extracts. Protein oxidation inhibition activity was only seen in extracts of strain YY. One-way ANOVA (analysis of variance) clearly showed that choice of solvent influenced the antioxidant capacity of all of the extracts.

Conclusions

Newer and efficient antioxidative compounds are constantly being searched for, and the carotenoid extracts of RP, TP and YY have been shown to catalyze various types of antioxidative reactions, including protein oxidation inhibition by YY. Thus, all these extracts have huge potential to be industrially and pharmaceutically useful.
Estimating the Risks of Breast Cancer Radiotherapy: Evidence From Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials
Authors: Taylor Carolyn , Correa Candace , Duane Frances K. , Aznar Marianne C. , Anderson Stewart J. , Bergh Jonas , Dodwell David , Ewertz Marianne , Gray Richard , Jagsi Reshma , Pierce Lori , Pritchard Kathleen I. , Swain Sandra , Wang Zhe , Wang Yaochen , Whelan Tim , Peto Richard , McGale Paul ,   for the Early Breast Cancer Trialists’ Collaborative Group
Published: March 2017

Purpose

Radiotherapy reduces the absolute risk of breast cancer mortality by a few percentage points in suitable women but can cause a second cancer or heart disease decades later. We estimated the absolute long-term risks of modern breast cancer radiotherapy.

Methods

First, a systematic literature review was performed of lung and heart doses in breast cancer regimens published during 2010 to 2015. Second, individual patient data meta-analyses of 40,781 women randomly assigned to breast cancer radiotherapy versus no radiotherapy in 75 trials yielded rate ratios (RRs) for second primary cancers and cause-specific mortality and excess RRs (ERRs) per Gy for incident lung cancer and cardiac mortality. Smoking status was unavailable. Third, the lung or heart ERRs per Gy in the trials and the 2010 to 2015 doses were combined and applied to current smoker and nonsmoker lung cancer and cardiac mortality rates in population-based data.

Results

Average doses from 647 regimens published during 2010 to 2015 were 5.7 Gy for whole lung and 4.4 Gy for whole heart. The median year of irradiation was 2010 (interquartile range [IQR], 2008 to 2011). Meta-analyses yielded lung cancer incidence ≥ 10 years after radiotherapy RR of 2.10 (95% CI, 1.48 to 2.98; P < .001) on the basis of 134 cancers, indicating 0.11 (95% CI, 0.05 to 0.20) ERR per Gy whole-lung dose. For cardiac mortality, RR was 1.30 (95% CI, 1.15 to 1.46; P < .001) on the basis of 1,253 cardiac deaths. Detailed analyses indicated 0.04 (95% CI, 0.02 to 0.06) ERR per Gy whole-heart dose. Estimated absolute risks from modern radiotherapy were as follows: lung cancer, approximately 4% for long-term continuing smokers and 0.3% for nonsmokers; and cardiac mortality, approximately 1% for smokers and 0.3% for nonsmokers.

Conclusion

For long-term smokers, the absolute risks of modern radiotherapy may outweigh the benefits, yet for most nonsmokers (and ex-smokers), the benefits of radiotherapy far outweigh the risks. Hence, smoking can determine the net effect of radiotherapy on mortality, but smoking cessation substantially reduces radiotherapy risk.
Further Reflections on Sentences Saying of Themselves Strange Things
Authors: Zardini Elia
Published: March 2017

Milne [2005] argued that a sentence saying of itself that it does not have a truthmaker is true but does not have a truthmaker. López de Sa and Zardini [2006] worried that, by parity of reasoning, one should conclude that a sentence saying of itself that it is not both true and short is true but not short. Recently, Milne [2013] and Gołosz [2015] have replied to López de Sa and Zardini’s worry, arguing in different ways that the worry is illfounded. In this paper, I’ll address these replies and argue that they fail to dispel López de Sa and Zardini’s worry, bringing out in the process some broader points concerning the use of self-referential sentences in arguments in philosophy of logic.
I wish to register a complaint
Authors: MacLeavy Christine
Published: March 2017

Can you handle patients? Christine MacLeavy considers the scenarios, the options and the road to a successful resolution
Cheers to a happy New Year
Authors: Eder Andrew
Published: March 2017

With New Year's Eve and its associated celebrations fast approaching, Professor Andrew Eder considers the erosive potential of alcohol, and offers both preventive and treatment solutions
Antibiotics and daily practice
Authors: Hancocks Stephen
Published: March 2017

Stephen Hancocks gives an overview of antibiotics in the dental setting, when they should not be used, or used only after very careful consideration
What's the dress code?
Authors: Hurley Janice
Published: March 2017

Janice Hurley explains why a standard dress code needs to be implemented in practice
Orthodontic nursing – past, present and future
Authors: Henderson Kelly
Published: March 2017

Kelly Henderson considers how the evolving world of dentistry is keeping pace with orthodontic nursing
New year, new path
Authors: Hancock Dave
Published: March 2017

Are extended duties for dental nurses a golden opportunity for you in the coming year? Dave Hancock investigates
Tailor-made oral health care
Authors: Greener-Simon Carly
Published: March 2017

Carly Greener-Simon reveals how she went from dental phobic to dental nurse and shares the rewards of community care
X-ray vision
Authors: Henderson Kelly
Published: March 2017

Kelly Henderson considers quality assurance and auditing in dental radiography
Why dentistry rocks in under 100 words
Authors: Bissett Julie
Published: March 2017

Cost is irrelevant when a trip to the dentist might save a life. Perhaps it's time to talk, suggests Julie Bissett
How to handle a heart attack
Authors: Berridge Wendy
Published: March 2017

Don't take a gamble. Make sure the whole team knows how to handle a medical emergency in the practice. Here, Wendy Berridge hands you ace tips on dealing with angina and heart attack victims
Leadership and supervision
Authors: Fowler John
Published: March 2017

This series continues to explore the leadership skills of the dental nurse. With John Fowler
Social media – does the dental world need it?
Authors: Smethurst Christine
Published: March 2017

Just why has dentistry been so slow to embrace the many marketing opportunities of internet activity? Christine Smethurst assesses the amalgam of an online and dental world
A brush with the digital age
Authors: Chatfield Christina
Published: March 2017

What one dental hygienist thought of ‘possibly THE cleverest toothbrush ever’
A dental nurse's role in safeguarding
Authors: Wake Charlotte
Published: March 2017

You will struggle to find a more important role for any member of the dental team than their role of safeguarding, says Charlotte Wake
An Olympic performance
Authors: Gibson David
Published: March 2017

A look at the benefits of real time, fully automatic cycle data management, a technology that has featured in both the success enjoyed by Team GB's Olympic sailing and rowing squads and, more recently, as part of the America's Cup challenge
Early dental decay – is it simply fuelled by a lack of knowledge?
Authors: Stevens Claire
Published: March 2017

Claire Stevens, a consultant in paediatric dentistry, is passionate about changing the tide on kids' poor oral health and believes that non-judgemental sharing of information is the way forward. She talks to Julie Bissett
Are you happy in your career?
Authors: Duffy Paul
Published: March 2017

With dental nurse salaries a hot topic, we hear from Paul Duffy on why he hopes his research study on job satisfaction may highlight the crux of the matter
The ultimate factory reset
Authors: Takacs Hajnalka
Published: March 2017

Hajnalka Takacs reveals why dental nursing was the perfect escape from the monotony of the production line
They need you!
Authors: Thomas Megan
Published: March 2017

Meet former dental nurse and dental hygienist Megan Thomas who wants you to join her in targeting dental health care to those who need it most by getting involved with BrushUpUK
Are you allergy aware?
Authors: Berridge Wendy
Published: March 2017

In the occasional series looking at medical emergencies, Wendy Bainbridge focuses on anaphylaxis
Modeling and simulation of bus assem-bling process using DES/ABS approach
Authors: Pawlewski Pawel , Kluska Kamila
Published: March 2017

This paper presents the results of the project, which goal is to analyze the production process capability after reengineering the assembly process due to expansion of a bus production plant. The verification of the designed work organization for the new configuration of workstations on new production hall is necessary. To solve these  problems authors propose a method based on mixing DES (Discrete Event Simulation) and ABS (Agent Based Simulation) approach. DES is using to model the main process – material flow (buses), ABS is using to model assembling operations of teams of  workers.One of obtained goal is to build a simulation model, which presents the new assembly line in the factory, taking into ac-count the arrangement of workstations and work teams in the new production hall as well as the transport between workstations. Second goal is to present work organization of work teams and division of individual workers’ labor (who belongs to a particular work team and performs operations on buses in a particular workstation) in order to determine the best allocation of tasks and the optimum size of individual work teams. Proposed solution enables to determine the effect of assembly interferences on the work of particular work teams and the efficiency of the whole production system, to define the efficiency of the designed assembly lines and proposing changes aimed at the quality improvement of the created conception.
Kernel-based framework for spectral dimensionality reduction and clustering formulation: A theoretical study
Authors: Blanco Valencia Xiomara Patricia , Becerra M. A. , Castro Ospina A. E. , Ortega Adarme M. , Viveros Melo D. , Peluffo Ordóñez D. H.
Published: March 2017

This work outlines a unified formulation to represent spectral approaches for both dimensionality reduction and clustering. Proposed formulation starts with a generic latent variable model in terms of the projected input data matrix.Particularly, such a projection maps data onto a unknown high-dimensional space. Regarding this model, a generalized optimization problem is stated using quadratic formulations and a least-squares support vector machine.The solution of the optimization is addressed through a primal-dual scheme.Once latent variables and parameters are determined, the resultant model outputs a versatile projected matrix able to represent data in a low-dimensional space, as well as to provide information about clusters. Particularly, proposedformulation yields solutions for kernel spectral clustering and weighted-kernel principal component analysis.
Between the Profiles Pay Per View and the Protection of Personal Data: the Product is You
Authors: Chávez Valdivia Ana Karin
Published: March 2017

Perhaps in the past was difficult to imagine that the moment in which someone could register each purchase that has been made, each book that has been read or each thing that has been said would come. That there would be companies storing data about our physical activity, behaviors, preferences and choices all the time. Most of the personal data comes from acts as daily as installing an application, completing a form, purchasing a product or requesting a service. This information provided sometimes consciously, voluntarily and with relative knowledge of the destination that will have, contrasts with situations in which data are inferred, deduced, extracted and manipulated.  In this sense, within a context in which the only access to the database has been left behind to give way to the creation of these by third parties, we wonder about the possible denaturation of the personal data and sensitive information that when get transformed in raw material through the analysis of existent connections and extraction of new data implicit in the multitude of information compiled in public or private databases, would convert  people into an essential product for the market; while the development of citizen profiles pay per view would allow predicting behaviors, selections and multiple deployments in different aspects of our lives. It is probable that in the defenselessness condition where we are now for having passed from personal space to social one and from there to the market many times without our knowledge and consent makes necessary to reconsider the current forms of protection and mechanisms of  legal protection around our personal data.
Hubungan antara Aktivitas Fisik Terhadap Memori Kerja Murid SMA Don Bosco III Bekasi
Authors: Junaidi Michelle Clarissa , Soegiarto Bertha
Published: March 2017

Latar belakang. Memori kerja merupakan bagian dari memori jangka pendek yang berperan penting dalam membantu proses pembelajaran dan dipengaruhi oleh aktivitas fisik, memori kerja yang rendah akan menimbulkan kesulitan untuk menerima informasi baru serta penurunan prestasi belajar. Tujuan. Mengetahui pengaruh aktivitas fisik terhadap kapasitas memori kerja murid SMA Don Bosco III. Metode. Penelitian metode analitik dengan pendekatan potong lintang pada 113 murid SMA Don Bosco III, Bekasi, pada 18 – 20 Juli 2016. Penelitian dilakukan dengan menggunakan kuesioner demografi, kuesioner skrining gangguan mental dan penyakit kronis, Physical Acitivity Questionnaire of Adolescent (PAQ-A) dan Operation Span (O-SPAN). Analisis data dengan univariat dan bivariat menggunakan uji korelasi Spearman. Hasil. Terdapat 113 murid SMA Don Bosco III dengan kisaran usia 14 – 17 tahun, usia terbanyak 15 tahun (47.8%), laki-laki 61,1%, murid kelas X 44.2%. Mayoritas responden memiliki aktivitas fisik “kurang baik” dan rerata memori kerja 6,16. Analisis Spearman menunjukkan terdapat hubungan bermakna (p<0,05) antara aktivitas fisik terhadap memori kerja dengan korelasi positif lemah (r=0,384). Kesimpulan. Terdapat korelasi positif antara aktivitas fisik dan memori kerja, aktivitas fisik yang semakin tinggi cenderung akan meningkatkan memori kerja.
Perbandingan Diagnosis Systemic Lupus Erythematosus Menggunakan Kriteria American College of Rheumatologi dan Systemic Lupus International Collaborating Clinics
Authors: Karuniawaty Titi Pambudi , Sumadiono Sumadiono , Satria Cahya Dewi
Published: March 2017

Latar belakang. Systemic lupus erythematosus (SLE) merupakan penyakit autoimun yang melibatkan multi organ dengan spektrum klinis dan imunologis yang luas. Kriteria diagnostik SLE pertama kali diperkenalkan oleh American College of Rheumatology (ACR) pada 1971 dan telah mengalami revisi pada 1982 dan 1997. Tujuan. Membandingkan kriteria ACR dan kriteria SLICC dan menilai agreement antara kriteria SLICC dan ACR untuk menegakkan diagnosis SLE.Metode. Penelitian studi cross-sectional terhadap pasien SLE yang dirawat di bagian Anak RS Sardjito Yogyakarta antara Januari 2009-Juni 2015. Metode total sampling digunakan pada penelitian ini. Pengumpulan data dilakukan melalui rekam medis, untuk menilai masing-masing kriteria pada saat anak terdiagnosis SLE, kemudian dilakukan penilaian agreement di antara kedua kriteria tersebut.Hasil. Didapatkan 64 anak didiagnosis SLE dan 46 (71,9%) memenuhi kriteria ACR. Sebanyak 39 (60,9%) memenuhi kriteria SLICC. Penelitian ini mendapatkan overall agreement yang baik (ρ0=0,70) di antara kedua kriteria tersebut, dengan chance-corrected agreement κ=0,33, atau dinyatakan cukup.Kesimpulan. Kriteria SLICC memiliki agreement yang cukup baik dengan kriteria ACR. Kriteria SLICC dapat dipertimbangkan sebagai alternatif metode untuk menegakkan diagnosis SLE pada anak. Perlu penelitian lanjutan untuk menilai kemungkinan penerapan kriteria ini untuk menggantikan kriteria ACR yang telah dipakai secara luas sebelumnya.
Mastoscopic sentinel lymph node biopsy in breast
cancer
Authors: Ding Boni , Zhang Hongyan , Li Xiaorong , Qian Liyuan , Chen Xuedong , Wu Wei , Wen Yanguang , Zhao Yujun
Published: March 2017

Background: Previous studies have demonstrated
that mastoscopic sentinel lymph node biopsy
(MSLNB) has good identification rate (IR) and low false
negative rate (FNR). However, few studies have directly
compared the surgical performance and peri- and post-operative
factors of MSLNB with conventional sentinel lymph
node biopsy (SLNB).

Methodology: Sixty patients diagnosed with breast cancer
were recruited and randomly assigned to one of the three
groups: MSLNB, SLNB and SLNB with lipolysis injection.
Peri- and post-operative parameters were compared using
general linear models. To examine the effect of age on
these parameters, we performed separate analysis stratified
by age (≤50 years old vs. >50 years old).

Results: Patients in the MSLNB group experienced longer
surgery and suffered higher surgical cost than patients
who underwent conventional SLNB or SLNB with lipolysis
injection (p<0.0001). Despite this, they had significantly
less blood loss than those who underwent conventional
SLNB (22.0±7.0 ml vs.73.5±39.6 ml; p<0.0001). Analysis by
age group indicates a similar pattern of difference among
the three groups. MSLNB and conventional SLNB have
similar IR and FNR.

Conclusion: As a minimally invasive technique, MSLNB
can significantly reduce blood loss while providing similar
IR and FNR, indicating that it can be a promising alternative
to conventional SLNB.

Conclusion: Variations in popliteal artery terminal
branching pattern occurred in 7.4% to 17.6% of patients.
Pre-surgical detection of these variations with MD CTA
may help to reduce the risk of iatrogenic arterial injury by
enabling a better surgical treatment plan.
The role of 99mTc-MIBI SPECT-CT in reoperation therapy of persistent hyperparathyroidism patients
Authors: Yin Lijie , Guo Dandan , Liu Jie , Yan Jue
Published: March 2017

To compare the role of 99mTc-MIBI SPECT-CT image and US in reoperation of persistent secondary hyperparathyroidism patients. A total of 8 persistent secondary hyperparathyroidism patients underwent parathyroidectomy. The sensitivity and accuracy of US and 99mTc-MIBI images before operation were determined. 9 of 14 surgical resection tissues from 8 persistent secondary hyperparathyroidism patients were confirmed to parathyroid hyperplasia. The results showed that the sensitivities were 77.8% and 100%, respectively, for US and 99mTc-MIBI SPECT-CT images. And the accuracies of US and 99mTc-MIBI dual time planar image and SPECT-CT were 50%, 78.6%, respectively. There was significantly difference between two procedures (P=0.021). The superior and inferior localization of glands were both detected by the ultrasound and scintigraphy. Two ectopic parathyroidism nodules were found by 99mTc- MIBI SPECT-CT imaging, while US provided no consistent findings. There was no significantly difference between two procedures (P=0.3). Although two cases of them were not confirmed by pathology, the iPTH of them (800 and 1429 respectively) were much higher than other four cases (<400) pg/ml. PTX is a safe and effective treatment for the patients with persistent SHPT. 99mTc-MIBI planar and SPECT-CT imaging may provide more helps for clinician’s localization the hyperparathyroidism glands accurately.
Analysis of the Best Timing for Applying Tirofiban in PCI Operation for the Patients with ST Segment Elevation Myocardial Infarction
Authors: Lei Zhang , Xiaoming Zhong , Yan Hong , Ming Zhong Xiao
Published: March 2017

This study is a comparative analysis of the best timing for applying tirofiban in the PCI emergency treatment for STEMI patients. We selected 109 patients with ST-segment elevation myocardial infarction from October 2013 to October 2014 and divided them into two groups, the early treatment group (53 cases) received tirofiban during the operation and the later treatment group (56 cases) received tirofiban after operation. The analysis was then conducted. Results: The proportion of IRA forward flow in TIMI2-3 for the 1st group during the radiography was higher than 2nd group, 50 cases with TIMI3 blood flow and 52 cases with TIMI3 blood flow in later treatment group. Comparing the TIMI3 flow of both groups, the difference was not statistically significant; for the CK-MB 4h and 8h after operation as well as the LVEF after operation, the differences are were not statistically significant. The occurrence rate of hemorrhage complication was low for both groups. The early use of tirofiban can make the thrombus fully dissolve and coronary blood flow remains in a good state, which is not only beneficial for myocardial perfusion but also helpful for deciding the length and side branch situation of coronary artery pathological changes.
Application of Food-specific IgG Antibody Detection in Allergy Dermatosis
Authors: Yine Hu , Shufang Dai , Bin Wang , Wei Qu , Aqeel Ashraf Muhammad , Junling Gao
Published: March 2017

The application of food-specific IgG antibody detection in allergy dermatoses was explored. 181 patients with allergy dermatoses were diagnosed from January to September 2014 and 20 healthy subjects were selected. Fourteen kinds of food-specific IgG antibodies were detected by ELISA method among all the subjects. The positive rates of IgG antibody of the patient group and the healthy group were respectively 65.2% and 5.0%. The positive rates of IgG antibody of egg, milk, shrimp and crab took a large proportion in three groups of patients with three kinds of allergy dermatoses of urticaria, eczema and allergic dermatitis, the proportion of which was respectively 70.2%, 77.8% and 71.7%. Among urticaria and allergic dermatitis patients with positive antibody, the positive rate of children was significantly higher than that of adults (p<0.05) while there was no significant difference between children and adults among eczema patients with positive antibody (p>0.05). Allergy dermatoses are closely related to food-specific IgG antibodies, and the allergy dermatoses patients have a high incidence rate of food intolerance; detecting IgG antibody in the serum of patients is of great significance for the diagnosis and treatment of allergy dermatoses.
Research into the Value of B-Mode Ultrasound, CT and MRI Examinations in the Diagnosis of Preoperative Myometrial Infiltration of Endometrial Cancer and Lymph Node Metastasis
Authors: Lu Ren , Guixia Sun
Published: March 2017

This study is conducted to observe the diagnostic value of B-mode ultrasound, CT and MRI examinations in preoperative myometrial infiltration of endometrial cancer and lymph node metastasis. Retrospectively analyze 50 cases of the patients from Oct. 2010 to Aug. 2013. Before operation all the patients received dilatation & curettage to determine pathological diagnosis and clinical staging. There were 150 cases of patients who received B-mode ultrasound examination, wherein, 93 cases received CT examination and 57 cases received MRI examination as well. In the diagnosis of MIEC the diagnostic indicies of individual MRI examination were higher than that of individual B-mode ultrasound and CT examinations. Consistency of individual MRI examination with pathological diagnosis was significantly higher than that of B-mode and CT examinations. The sensitivity of CT and MRI was significantly higher than that of B-mode ultrasound examination. However, diagnostic indicators of B-mode ultrasound and CT joint examination were higher than B-mode ultrasound examination alone. The consistency of both with pathological diagnosis was significantly increased. B-mode and CT can significantly improve the diagnostic accuracy and has a good consistency with pathological diagnosis, thereby applicable to the clinical diagnosis of preoperative myometrial infiltration of endometrial cancer and lymph node metastasis.
Feasibility and safety of prophylactic tentorium cerebelli hiatus incision in surgery of glioma located in lateral fissure area
Authors: Jin’an Zhao , Yamei Gao , Huanli Yang
Published: March 2017

To discuss the feasibility and safety of prophylactic tentorium cerebelli hiatus incision in surgery of glioma located in lateral fissure area. There were 80 patients with glioma located in lateral fissure area who received treatment from May 2012 to May 2015, divided into two groups, the research group (n=40) and control group (n=40), and then statistical analysis was carried out. Difference in total resection rate and subtotal resection rate of glioma between patients of the research group and those of the control group was not significant (P>0.05); intracranial pressure of patients in the research group was significantly lower than that of control group (P<0.05), their hospital stay was significantly shorter than that of the control group (P<0.05), times of using mannitol were significantly fewer than control group (P<0.05), but the differences of acute renal function damage and second surgery occurrence rate between patients of the two groups were not significant (P>0.05). Prophylactic tentorium cerebelli hiatus incision in surgery of glioma located in lateral fissure area can effectively reduce patients’ intracranial pressure, shorten patients’ hospital stay and reduce patients’ times of using mannitol without increasing the rate of patients’ acute renal function damage and second surgery.
Laparoscopic splenectomy and porto-azygos disconnection: clinical research in the treatment of portal hypertension
Authors: Fengyong Wang , Yuanshui Sun , Zhangbing  , Yuewu Wu , Weihua Zhan , Jianfeng Shi , Qi Wu , Jinming Liu , Ji Xu , Zaiyuan Ye
Published: March 2017

To investigate the safety and efficacy of laparoscopic splenectomy and portaazygous devascularization, we studied laparoscopic splenectomy and porto-azygos devascularization patients within the peri-operative period. Clinical data and curative effect are detailed alongside statistical analysis. The laparoscopic splenectomy and porto-azygos devascularization operation time was 2.56 + 0.62 hours. The intraoperative bleeding and anal exhaust time was 149.5 + 32.7ml 3.47 + 1.32 days, and the hospitalization time was 5.05 + 1.22 days. When the spleen volume was greater than or equal to 1.5 liters, the rate of open abdominal surgery increased significantly. After 1, 2, 3, and 4 years of follow-up, cumulative recurrence bleeding rates were 0, 5.20%, 9.98%, and 15.83%, respectively. Laparoscopic splenectomy and pericardial devascularization is safe, effective, and feasible, and it can be confirmed by enhanced spiral computed tomography (CT). Whether spleen volume greater than 1.5L is suited to laparoscopic surgery requires further research.
Assessment of the feasibility of TACE combined with intratumoral injection of cisplatin in hepatocellular carcinoma
Authors: Zhaomin Song , Zifeng Liu , Chenghui Yin , Jiali Yang , Xun Peng , Peili Zhao , Xiaolin Lang
Published: March 2017

The feasibility of transcatheter arterial chemoembolization (TACE) combined with intratumoral injection of cisplatin as treatment for hepatocellular carcinoma. 30 cases receiving TACE were denoted the TACE group, another 30 cases receiving TACE combined with an intratumoral multi-point injection of cisplatin were denoted the TACE/cisplatin group. Cases with partial remission/complete remission (PR/CR) were analyzed using 2 tests; alpha fetoprotein (AFP), aspartate amino transferase (AST), total bilirubin (TBIL), erythrocyte, and platelet levels were detected and the differences between two groups were analyzed using the Student’s t-test; cases with complications, including intrahepatic metastasis (IM), upper gastrointestinal bleeding (UGB), and liver failure were also counted. The correlation of clinical parameters with PR/CR was analyzed using multifactorial correlation analysis. Cases with PR/CR in the TACE/cisplatin group were significantly more than in TACE group, accompanied by significant declination in FAP. There were no significant differences of AST, ALT, TBIL, blood urea nitrogen (BUN), white blood cells (WBC), red blood cells (RBC), and platelets (PLT) between two groups; 3 cases with IM, one case with UGB and one case with LF were found in the TACE group, but only 1 case with IM was found in the TACE/cisplatin group. In addition, tumor stage was correlated with PR/CR. We concluded that TACE combined with intratumoral injection of cisplatin was more effective than TACE, and with fewer complications and side effects.
The pharmacological research of Tek-1 relevance to anti-neuroinflammation, a candidate compound based on Telmisartan
Authors: Yang Jianbo , Cui Changcong
Published: March 2017

In this paper, BV-2 mouse small glial cell inflammation model induced by LPS is established. The experiment used 0.1-10 μM of telmisartan and Tek-1 to incubate with small glial cell and used telmisartan and Tek-1 to incubate with PPAR gamma special heterosexual antagonistic anti-agent GW9662. The article used ELISA method to dectect TNF-a effect on small glial cell for telmisartan and Tek-1. The article used real-time quantitative PCR method to dectect mRNA level expression effect of CD11b, CD16 and iNOS on small glial cell for telmisartan and Tek-1 and used Western Blot method to dectect MAPKs signal pathway and NF-κb signal turned guide pathway effect on small glial cell for telmisartan and Tek-1. Results show that Tek-1 had high affinity with AT1 receptor and inhibited intracellular calcium ion activation which can be for the AT1 receptor antagonists. Meanwhile, Tek-1 can partially activate PPAR gamma compared with full agonists of rosiglitazone.