bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and Prognostic Value of Molecular Markers of Diffuse Large B-Cell Lymphoma
Authors: Rastorguev S.M. , Koroleva D.A. , Boulygina E.S. , Tsygankova S.V. , Goncharov N.G. , Naraikin O.S. , Gabeeva N.G. , Zvonkov E.E. , Nedoluzhko Artem Valer'evich
Published: January 2019

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid tumor in adults which is associated with approximately 30-40 % of all non-Hodgkin’s lymphomas. Diagnostic criteria include diffuse growth of large anaplastic tumor cells, expression of В-cell markers, and a high proliferative index. Due to the development of molecular genetic technologies it became obvious that underlying cause of clinical diversity is a huge amount of genetic failures which determine epigenetic modification of gene expression, activation variability of certain signaling pathways, and immunological properties of tumor cells. The study and systemization of molecular markers present a significant trend in DLBCL diagnosis and treatment. This review discusses most important molecular markers and current view on their clinical value.
Plant Population and Fungicide Economically Reduced Winter Wheat Yield Gap in Kansas
Authors: Jaenisch Brent R. , de Oliveira Silva Amanda , DeWolf Erick , Ruiz‐Diaz Dorivar A. , Lollato Romulo P.
Published: January 2019

Core Ideas

Prophylactic applications of high input rates was not economical in most marketing scenarios

The only exception was using low‐cost fungicides and marketing wheat with a protein premium

Increased plant population economically reduced wheat yield gap in no‐tillage systems

Fungicide application economically reduced wheat yield gap under high‐disease pressure

Evidence suggested wheat yield was co‐limited by sink and source in our study

Despite the large differences between winter wheat (Triticum aestivum L.) current and potential yields (i.e., yield gap, YG) in Kansas, limited research is available on individual agronomic practices, or their combination, economically increasing yield. Our objective was to quantify the contribution of individual and combined management practices to reduce the wheat YG. An incomplete factorial treatment structure established in a randomized complete block design was conducted to evaluate the effects of 14 treatments on yield, YG, protein concentration, and net returns. The variety ‘Everest’ was evaluated at three locations in 2016 and 2017. We individually added six treatments to a farmer practice control (FP) or removed from a water‐limited yield control (Yw), which received all treatments. Treatments were: additional N, S, Cl, increased plant population, foliar fungicide, and plant growth regulator. Under no‐till which had low disease pressure, the Yw increased grain yield by 0.4 Mg ha−1 as compared with FP, mostly led by additional N, S, increased population, and fungicide (0.2–0.4 Mg ha−1). In conventional till which had high‐disease pressure, the Yw increased grain yield by 1.2 Mg ha−1 as compared with the FP, and foliar fungicide increased grain yield by 1.4 Mg ha−1. Foliar fungicide and increased plant population economically reduced the YG for conventional till and no‐till, respectively. Net return analysis indicated that intensifying wheat management might be justifiable when using low‐cost fungicides and if protein premiums are expected. Our results suggest that an integrated pest management should be preferred over an Yw approach with prophylactic pesticide application.
Yield Monitor Data Cleaning is Essential for Accurate Corn Grain and Silage Yield Determination
Authors: Kharel T.P. , Swink S.N. , Maresma A. , Youngerman C. , Kharel D. , Czymmek K.J. , Ketterings Q.M.
Published: January 2019

Core Ideas

Corn silage and grain yield monitors collect yield data of relevance to farmers.

Evaluation of quality of yield monitor data is essential, especially for silage.

A data cleaning protocol, consistent across fields, farms, and years, is needed.

Semi‐automation is needed for quick and consistent processing of whole‐farm data.

Yield monitor data are being used for a variety of purposes including conducting on‐farm studies, assessing nutrient balances, determining yield potential, and creating management zones. However, standardization of raw data processing is needed to obtain comparable data across fields, farms, and years. Our objective was to evaluate the impact of data cleaning protocols on corn (Zea maysL.) grain and silage yield data at the whole field (with and without headlands) and within field (soil map unit) scales. Corn silage data from 145 fields (three farms) and grain data from 88 fields (three farms) were processed. Comparisons were made to evaluate yields among three levels of cleaning: (i) none; (ii) automated cleaning (“Auto”) with filter settings derived for 10 fields per farm; and (iii) automated cleaning with manual inspection for unrepresentative patterns, after the automated cleaning step was completed (“Auto+”). The Auto+ cleaning process was conducted separately by three individuals to evaluate person‐to‐person differences. Spatial Management System software was used to read raw data and transfer to Ag Leader format. Yield Editor software was used to clean data (Auto and Auto+). Results showed the necessity of data cleaning, especially for corn silage. However, considering less than 5% deviation between methods at three spatial scales, the Auto and Auto+ cleaning resulted in similar output, as long as (i) each field or subfield included at least 100 harvester measurement points, and (ii) a moisture filter was applied for corn silage data.
Seed and Biomass Yield Responses of Blessed Thistle to Nitrogen and Density
Authors: Ghiasy‐Oskoee M. , AghaAlikhani M. , Mokhtassi‐Bidgoli A. , Sefidkon F. , Ayyari M.
Published: January 2019

Core Ideas

This is the first report of blessed thistle response to nitrogen and plant density.

Optimizing nitrogen and density improved quality and quantity of blessed thistle seed.

Under low yielding conditions, the actual yield of blessed thistle is acceptable.

Blessed thistle is rich in polyunsaturated fatty acids such as linoleic acid.

Developing alternative oilseed crops with acceptable seed yield and biomass production in low‐yielding environments could be a part of sustainable agriculture management strategies. Field experiments were conducted in a semiarid region of Iran in 2013 and 2014 to determine the effects of N fertilizer rates and plant densities on growth, seed yield and quality of blessed thistle (Cnicus benedictus L.) under low yielding conditions. Randomized complete‐block design with factorial arrangement of treatments was used in three replicates. Treatments consisted of four N rates (0, 50, 100, and 150 kg N ha−1) combined with five plant densities (5, 10, 15, 20, and 25 plants m−2). According to quadratic functions, the maximum seed yield (913 kg ha−1) was achieved with 122 kg N ha−1 and 16 plants m−2. Although the seed oil content decreased with increasing N rates, increased seed yield partially compensated for the reduction in oil content. Higher seed protein was obtained from low plant densities (5–10 plants m−2) and high N rates (100–150 kg N ha−1). Nitrogen harvest index (NHI) decreased by 30 to 40% as a result of increased plant density across all N rates. Plant density and N did not affect seed fatty acid profiles, even though N rate by year interaction affected the profile. Linoleic acid was the predominant fatty acid comprising 62.5 to 66.2% of the total fatty acids. The study demonstrates that blessed thistle could be a promising oil crop for cultivation in low yielding soils, although breeding work is needed to enhance its prospects as a viable oil crop.
Nitrogen and Phosphorous Fertilizer Timing, Source, and Placement in Sugarbeet
Authors: DeBruyn Amanda H. , O’Halloran Ivan P. , Lauzon John D. , Van Eerd Laura L.
Published: January 2019

Core Ideas

Evaluated 4R strategies of fertilizer N source, placement, timing in sugarbeet.

No benefit of N with P fertilizer in 5‐ by 5‐cm band based on root and sucrose yield.

No need to modify fertilizer N and P based on anticipated sugarbeet harvest date.

Late harvest may mitigate N losses due to lower soil mineral N at late than early.

An industry‐led renaissance of nutrient management is occurring in North America to apply the correct rate, source, placement, and timing. Crop consultants have recently recommended including fertilizer N in a 5‐ by 5‐cm band during sugarbeet (Beta vulgaris L.) planting, but this practice has not been rigorously evaluated regarding its influence on N dynamics and/or yield. In 2013 to 2015 at two fields in southwestern Ontario, an experiment evaluated the impact of fertilizer application on sugarbeet (Beta vulgaris L.) productivity at two harvest timings (mid‐September vs. late October–early November). Treatments were a negative control: no fertilizer (N0P0), positive controls: pre‐plant broadcast incorporated N (NpreP0) and in‐season, injected N (NseasonP0) and six fertilizer application method and timing combinations, all at an equal N application rate (112 kg N ha−1) to determine the need to include both N and P applied in a 5‐ by 5‐cm band (N5x5P5x5). The lack of treatment × harvest date interaction on all parameters suggested no need to adjust fertilizer based on harvest date. Average root yield in N5x5P5x5 treatment was 82 Mg ha−1, which was 15 to 20 Mg ha−1 greater than N0P0 but not different than other treatments. Sucrose yield and soil mineral nitrogen (SMN) did not differ among the fertilized treatments. From an agronomic and environment perspective, there was little evidence to suggest the need to band fertilizer N with the seed.
Return on investment from biochar application
Authors: Sorensen Ronald B. , Lamb Marshall C.
Published: January 2019

Current research has yet to fully address the cost of biochar application or the return on investment to the grower. The objectives were to identify possible on‐farm spinner spreader equipment, spreader capacity, application expenses, and rate of return needed for growers to broadcast biochar economically. Earn 1 CEU in Soil & Water Management by reading this article and taking the quiz at www.certifiedcropadviser.org/education/classroom/classes/639.
Weed control with bicyclopyrone + bromoxynil in wheat
Authors: Martín Carolina San , Gourlie Jennifer , Barroso Judit , Lyon Drew J. , Wetzel Henry C.
Published: January 2019

Chemical weed control options in wheat cropping systems of the Pacific Northwest are currently limited due to the presence of resistant weed biotypes. The efficacy of a new post‐emergence herbicide in wheat, bicyclopyrone + bromoxynil (Talinor), was evaluated for mayweed chamomile and prickly lettuce control in eastern Washington and Oregon in 2016 and 2017. Earn 1 CEU in Integrated Pest Management by reading this article and taking the quiz at www.certifiedcropadviser.org/education/classroom/classes/641.
Context‐Specific Genomic Selection Strategies Outperform Phenotypic Selection for Soybean Quantitative Traits in the Progeny Row Stage
Authors: Smallwood Christopher J. , Saxton Arnold M. , Gillman Jason D. , Bhandari Hem S. , Wadl Phillip A. , Fallen Benjamin D. , Hyten David L. , Song Qijian , Pantalone Vincent R.
Published: January 2019

Evaluating different breeding selection strategies for relative utility is necessary to choose those that maximize efficiency. Soybean [Glycine max (L.) Merr.] seed yield and fatty acid, protein, and oil contents are all commercially important traits that display complex quantitative inheritance. A soybean population consisting of 860 F5–derived recombinant inbred lines (RILs), genotyped with 4867 polymorphic single nucleotide polymorphism (SNPs) was used to compare phenotypic and context specific genomic selection (GS) strategies. To simulate progeny rows, each RIL was grown in a single plot in 2010 in Knoxville, TN, and phenotype was recorded. A subset of 276 RILs with similar maturity was then grown in multilocation, replicated field trials in 2013 to compare the performance of each selection method in field conditions. Notably, the preferred method for each trait was GS. Of the GS approaches evaluated, Epistacy performed best for yield, and BayesB and/or genomic best linear unbiased prediction (G‐BLUP) were preferred for each of the other traits. Yield was the only trait for which the predictions had a large change when the number of SNPs and the number of RILs were randomly reduced for the G‐BLUP model, with the best predictions occurring when RILs with different maturity that were not grown in 2013 were removed from the training set. These findings provide important information on how soybean breeders can maximize selections from the progeny row stage for yield and fatty acid, protein, and oil contents by using appropriate selection strategies.
Identification of Reference Genes for qRT‐PCR Gene Expression Studies during Seed Development and under Abiotic Stresses in Cyamopsis tetragonoloba
Authors: Jaiswal Poonam Subhash , Kaur Navneet , Randhawa Gursharn Singh
Published: January 2019

Guar [Cyamopsis tetragonoloba (L.) Taubert] is an important industrial crop. The knowledge about genes of guar involved in various processes can help in developing improved varieties of this crop. Quantitative real‐time polymerase chain reaction (qRT‐PCR) is a preferred technique for accurate quantification of gene expression data. This technique requires the use of appropriate reference genes from the crop to be studied. Such genes have not been yet identified in guar. The expression stabilities of the 10 candidate reference genes (CYP, ACT 11, EF‐1α, TUA, TUB, ACT 7, UBQ 10, UBC 2, GAPDH, and 18S rRNA) were evaluated in various tissues of guar under normal and abiotic stress conditions. Four different algorithms (geNorm, NormFinder, BestKeeper, and ΔCt approach) were used to assess the expression stabilities and the results obtained were integrated into comprehensive stability rankings. The most stable reference genes were found to be CYP and ACT 11 (tissues); ACT 11, UBC 2, and ACT 7 (seed development); ACT 7 and TUB (drought stress); TUA, UBC 2, and CYP (N stress); TUA and UBC 2 (cold stress); GAPDH and ACT 7 (heat stress); and GAPDH and EF‐1α (salt stress). These results indicate the necessity of identifying a suitable reference gene for each experimental condition. Four selected reference genes were validated by normalizing the expression of CtMT1 gene. To the best of our knowledge, this is the first report on the identification of reference genes in guar. These findings are likely to provide a boost to the gene expression studies in this important crop.
Effect of Drought–Flood Abrupt Alternation on Rice Yield and Yield Components
Authors: Gao Yun , Hu Tiesong , Wang Qin , Yuan Hongwei , Yang Jiwei
Published: January 2019

The purpose of this paper is to clarify the compensation or reduction effect of drought–flood abrupt alternation (DFAA) events on the yield and yield components of rice (Oryza sativa L.). The experiments, conducted in 2016 and 2017, were on three different drought and flood treatments and compared with normal irrigation conditions. Compared with the normal control group, the average yield reduction of the DFAA groups was 12.98% in 2016 and 29.94% in 2017, and the combination of heavy droughts and heavy flooding was the most unfavorable for yield. The reduction in grains per panicle and the total grain number was the main reason for yield reduction under DFAA stress. The damage in terms of the total grain number amounted to 18.84 and 17.82% in 2016 and 2017, respectively. The interannual differences in the thousand‐seed mass and seed setting rate increased in 2016 and decreased in 2017. Compared with the drought groups and the flood groups, the flood stress of the DFAA groups reduced the yield under drought conditions, and the decrease in the total grain number and panicles per barrel during the flood period was the main reason. The drought stress of the DFAA groups compensated the yield under flood conditions, mainly because the total grain number and seed setting rate increased during the drought period. Under long‐term light drought conditions, the panicles per barrel, grains per panicle, total grain number, thousand‐seed mass, and seed setting rate increased. Under long‐term heavy drought conditions, the panicles per barrel mainly increased.
Devis ludique pour les modèles d’ingénierie de dispositifs pédagogiques | Gamification Specifications for Engineering Models of Educational Devices
Authors: Lortet Alain
Published: January 2019

Educational devices can include play-based elements, and even take the form of so-called serious video games combining educational and playful aspects. Educational engineering models, however, do not take into consideration the addition of play-based features in educational devices. As for engineering models targeting serious games, they are often designed for a specific genre. In this article, we propose the addition of gamification specifications to the ADDIE model for use in the development of serious games. The example used ultimately highlights the adaptability of the model created, which allows the modification of later versions of a serious game.Les dispositifs pédagogiques peuvent comporter des éléments ludiques et même prendre la forme de jeux vidéo dits sérieux qui combinent aspects pédagogique et ludique. Cependant, les modèles d’ingénierie pédagogique ne prennent pas en considération l’ajout de caractéristiques ludiques aux dispositifs pédagogiques. De leur côté, les modèles d’ingénierie ciblant les jeux sérieux sont souvent conçus pour un genre précis. Dans le présent article, nous proposons d’adjoindre un devis ludique au modèle ADDIE afin de l’utiliser pour l’ingénierie des jeux sérieux. Au final, l’exemple utilisé souligne l’adaptabilité du modèle créé qui permet la modification de versions ultérieures d’un même jeu sérieux.
Deviating From the Traditional Instructional Tools: Integrating Twitter in a Sociology of Deviance Course | S’éloigner des outils pédagogiques traditionnels : intégrer Twitter dans un cours sur la sociologie de la deviance
Authors: Peters Adrienne M.F. , Costello Jane , Crane Daph
Published: January 2019

As the use of social media in post-secondary education expands, so does the research literature examining its effectiveness in engaging students. Studies have examined the use of Twitter as an assessment and engagement tool, and since this is a broad and growing research area, better understanding whether Twitter can promote these outcomes in an upper-level university course is valuable. This paper explores these themes based on a student survey (N=37) conducted in a Sociology Deviance course. It also reviews how students responded to the use of Twitter as a “community-classroom” engagement and assessment tool. Findings reveal that Twitter did contribute to some students’ sense of community. We offer suggestions for how instructors can successfully integrate Twitter activities into their course assessment to make them more engaging and to improve connectedness.L’utilisation des médias sociaux dans l’éducation postsecondaire prend de l’ampleur, entraînant l’augmentation de la documentation de recherche qui examine leur efficacité à motiver les élèves. Des études se sont penchées sur l’utilisation de Twitter comme outil d’évaluation et de participation. Comme il s’agit d’un domaine de recherche vaste et en croissance, il est important de mieux comprendre si Twitter peut favoriser ces résultats dans le cadre d’un cours universitaire de haut niveau. Cet article explore ces thèmes en s’appuyant sur un sondage réalisé auprès des étudiants (N=37) dans un cours de sociologie de la déviance. Il examine également comment les étudiants ont réagi à l’usage de Twitter comme outil de participation à une « classe-collectivité » et comme outil d’évaluation. Les conclusions révèlent que Twitter a contribué au sentiment d’appartenance à la collectivité de certains étudiants. Nous offrons des suggestions sur la façon dont les instructeurs peuvent intégrer avec succès des activités liées à Twitter dans leurs évaluations de cours afin de rendre ceux-ci plus motivants et d’améliorer la connectivité.
Diagnosis of the hydrology of a small Arctic permafrost catchment using HBV conceptual rainfall-runoff model
Authors: Osuch Marzena , Wawrzyniak Tomasz , Nawrot Adam
Published: January 2019

Changes in active layer thickness (ALT) over Arctic and permafrost regions have an important impact on rainfall-runoff transformation. General warming is observed across Svalbard Archipelago and corresponds to increases in ground temperatures. Permafrost thaw and changes in ALT due to climate warming alter how water is routed and stored in catchments, and thus impact both surface and subsurface processes. The overall aim of the present study is to examine the relationships between temporal changes of active layer depth and hydrological model parameters, together with variation in the catchment response. The analysis was carried out for the small unglaciated catchment Fuglebekken, located in the vicinity of the Polish Polar Station Hornsund on Spitsbergen. For hydrological modelling, the conceptual rainfall-runoff HBV (Hydrologiska Byråns Vattenbalansavdelning) model was used. The model was calibrated and validated on runoff within subperiods. A moving window approach (3 weeks long) was applied to derive temporal variation of parameters. Model calibration, together with an estimation of parametric uncertainty, was carried out using the Shuffled Complex Evolution Metropolis algorithm. This allowed the dependence of HBV model parameters on ALT to be analysed. Also, we tested the influence of model simplification, correction of precipitation, and initial conditions on the modelling results.
A simple regional snow hydrological process-based snow depth model and its application in the Upper Yangtze River Basin
Authors: Ren Yanqun , Liu Suxia
Published: January 2019

Snow depth plays a significant role in the regional water balance, for which snowfall is usually determined by a fixed temperature threshold in regional snow research. This study developed a regional hydrological process-based snow depth model in the Upper Yangtze River Basin by using spatially distributed critical temperature data derived from Moderate Resolution Imaging Spectroradiometer (MODIS) data and station data. Based on meteorological station and remotely sensed data, daily snow hydrological components from 1 August 2003 to 31 July 2015 were simulated. Results show that the simulated snow depth patterns agreed with those of the observed snow depth. The multi-year average of the starting date and ending date of snow duration was 16 October and 6 June, respectively, and that of maximum annual snowfall was approximately 455 mm, of which canopy interception comprised 10%, with a maximum value of 50 mm. The proportion of snow sublimation was less than 20%, which was contributed by interception sublimation (40%), snow surface sublimation (40%) and sublimation underneath the canopy (20%). The maximum annual snow sublimation was 29 mm. Snow melting was the primary snow consumption pathway, and approximately 70% of snowfall melted. This research is significant for the assessment and management of water resources in this region.
Nano Alumina Catalytic Applications in Organic Transformations
Authors: Nikoofar Kobra , Shahedi Yeganeh , Chenarboo Faezeh Jame
Published: January 2019

Alumina (Aluminium Oxide, Al2O3), a white odorless solid powder is an inexpensive and widely used inorganic material which is insoluble in water and organic solvents. It may also be called aloxide, aloxite, or alundum. Nano forms of this inorganic metal oxide could be seen in different crystalline polymorphic phases for alumina, such as α-Al2O3, β-Al2O3, γ-Al2O3, δ-Al2O3, θ-Al2O3, η-Al2O3, κ-Al2O3, χ-Al2O3, and ρ-Al2O3. Generally, the nano size of alumina showed better activity due to its common form because of the vast surface area which led to larger surface-to-volume ratio. Alumina is a versatile substance in many compounds which possess interesting utility in biology, industry, and drugs. Nano alumina have been utilized in different branches of industry, medicine, and biology. It could play key role in abrasives, ceramics, and dental composites, electronic, absorbent, nano-carriers for delivery of anticancer, and surgical implants. Besides, it possesses particular position, as a heterogeneous Lewis acid catalyst or catalyst support in chemistry. Due to interesting properties of nano alumina in this report we focused on its catalytic activity in organic transformations. The review subdivided with centralization on reactions that progressed with sole nano alumina and the reactions which improved by nano alumina support catalysts. In is noteworthy that although many reactions have been reported by alumina catalytic role, the ones which underwent by nano-size aluminum oxides are few. This fact denote that this substance is a potent-catalyst system in future organic chemistry domain. The review describes the various organic reactions promoted by nano alumina catalysts relevant up to 2017.
Non-Invasive Ventilation in Stable Chronic Obstructive Pulmonary Disease
Authors: Valentin-Caius Cosei , Corina-Ioana Borcea , Ana-Maria Zaharie , Florin-Dumitru Mihaltan , Oana-Claudia Deleanu
Published: January 2019

The benefit of non-invasive ventilation (NIV) in stable chronic obstructive pulmonary disease (COPD) remains controversial. However, there is increasingly more evidence of NIV efficiency, especially high-flow NIV. This review presents the old and the new evidence of NIV effectiveness in stable COPD, considering pathophysiological arguments for NIV in COPD. Guidelines, randomized controlled trials (RCTs) and crossover studies included in review and metaanalysis based on patient-reported outcomes (PROs) have been analyzed. The role of NIV in rehabilitation and in palliative care and the role of telemedicine in relation with NIV are still up for debate. Challenges in choosing the right device and the optimal mode of ventilation still exist. There are also discussions on the criteria for patient inclusion and on how to meet them. More studies are needed to determine the ideal candidate for chronic NIV and to explain all the benefits of using NIV.
Simultaneous Determination of Imatinib and N-Desmethyl Imatinib in Rat Plasma and Tissues Using LC-MS/MS
Authors: Rao Zhi , Li Bo-xia , Jin Yong-Wen , Wen-Kou  , Ma Yan-rong , Zhang Guo-qiang , Zhang Fan , Zhou Yan , Wu Xin-an
Published: January 2019

Background:

Imatinib (IM) is a chemotherapy medication metabolized by CYP3A4 to Ndesmethyl imatinib (NDI), which shows similar pharmacologic activity to the parent drug. Although methods for determination of IM and/or NDI have been developed extensively, only few observations have been addressed to simultaneously determine IM and NDI in biological tissues such as liver, kidney, heart, brain and bone marrow.

Methods:

A validated LC-MS/MS method was developed for the quantitative determination of imatinib (IM) and N-desmethyl imatinib (NDI) from rat plasma, bone marrow, brain, heart, liver and kidney. The plasma samples were prepared by protein precipitation, and then the separation of the analytes was achieved using an Agilent Zorbax Eclipse Plus C18 column (4.6 × 100 mm, 3.5 µm) with gradient elution running water (A) and methanol (B). Mass spectrometric detection was achieved by a triplequadrupole mass spectrometer equipped with an electrospray source interface in positive ionization mode.

Results:

This method was used to investigate the pharmacokinetics and the tissue distributions in rats following oral administration of 25 mg/kg of IM. The pharmacokinetic profiles suggested that IM and NDI are disappeared faster in rats than human, and the tissue distribution results showed that IM and NDI had good tissue penetration and distribution, except for the brain. This is the first report about the large penetrations of IM and NDI in rat bone marrow.

Conclusion:

The method demonstrated good sensitivity, accuracy, precision and recovery in assays of IM and NDI in rats. The described assay was successfully applied for the evaluation of pharmacokinetics and distribution in the brain, heart, liver, kidney and bone marrow of IM and NDI after a single oral administration of IM to rats.
Beneficial Effects of Several Nanoparticles on the Growth of Different Plants Species
Authors: ul Haq Tauheed , Ullah Sami , Ullah Rehman
Published: January 2019

The excessive use of nitrogen and phosphorous fertilizers led to environmental pollution and serious health issues. Nanotechnology may solve such a type of problems by providing nanomaterials of high performance. Here, we reviewed the beneficial effects of some different nanoparticles on the growth of different parts of different plants belonging to 14 different families. Nanoparticles such as CNT, Ag-NPs, TiO2-NPs, Au-NPs, S-NPs, Ag-NPs+ Magnetic field-NPs, ZnO-NPs, Fe-NPs, SiO2-NPs, RA-NPs, Zinc-NPs, Silica-NPs, Apatite-NPs, CeO2-NPs, Cu-NPs, CaCO3-NPs, Chitosan- NKP-NPs and Carbon nono-tube coated NKP+ Chitosan NPK-NPs show better growth enhancement effect on different parts of plants and crop production when used in proper concentration. We find that the most favorable effect of NPs was on, chlorophyll contents, root and shoot length followed by proteins contents and plant biomass.
Inflammatory Cytokines and Biodegradable Scaffolds in Dental Mesenchymal Stem Cells Priming
Authors: Kanjevac Tatjana , Gustafson Collin , Ivanovska Ana , Ravanetti Francesca , Cacchioli Antonio , Bosnakovski Darko
Published: January 2019

Mesenchymal stem cells (MSCs) are multipotent stem cells with wide-ranging clinical applications due to their ability to regenerate tissue from mesenchymal origin and their capability of suppressing immune responses, thus reducing the likelihood of graft versus host disease after transplantation. MSCs can be isolated from a variety of sources including bone marrow, adipose tissue, umbilical cord blood, and immature teeth. Dental stem cells (DSCs) possess progenitor and immunomodulatory abilities as the other MSC types and because they can be easily isolated, are considered as attractive therapeutic agents in regenerative dentistry. Recently, it has been shown that DSCs seeded onto newly developed synthetic biomaterial scaffolds have retained their potential for proliferation and at the same time have enhanced capabilities for differentiation and immunosuppression. The scaffolds are becoming more efficient at MSC priming as researchers learn how short peptide sequences alter the adhesive and proliferative capabilities of the scaffolds by stimulating or inhibiting classical osteogenic pathways. New findings on how to modulate the inflammatory microenvironment, which can prime DSCs for differentiation, combined with the use of next generation scaffolds may significantly improve their therapeutic potential. In this review, we summarize current findings regarding DSCs as a potential regenerative therapy, including stem cell priming with inflammatory cytokines, types of scaffolds currently being explored and the modulation of scaffolds to regulate immune response and promote growth.
Role of Nanotechnology in Diabetic Management
Authors: Siwach Reena , Pandey Parijat , Chawla Viney , Dureja Harish
Published: January 2019

Background:

Diabetes Mellitus (DM) has emerged as an epidemic that has affected millions of people worldwide in the last few decades. Nanotechnology is a discipline that is concerned with material characteristics at nanoscale and offers novel techniques for disease detection, management and prevention.

Objective:

Diabetes mellitus is an epidemic disease that has affected millions of people globally. Nanotechnology has greatly enhanced the health status by providing non-obtrusive techniques for the management and treatment of diabetic patients.

Method:

In diabetes research, the nanotechnology has encouraged the advancement of novel glucose monitoring and several modalities for insulin delivery holding possibilities to enhance the personal satisfaction and life quality for diabetic patients.

Result:

Nanoparticles hold a great potential in the areas of drug delivery and are explored as vehicles for orally administered insulin formulations. Glucose biosensors equipped with nanoscale materials such as Quantum Dots (QDs), Carbon Nanotubes (CNTs), Magnetic Nanoparticles (MNPs) etc. have shown greater sensitivity. Nanotechnology in diabetic research is heading towards the novel techniques which can provide continuous glucose monitoring offering accurate information and improving patient’s compliance.

Conclusion:

The present review addresses the different aspects of nanoparticles and recent patents related to diabetic management based on nanotechnology.
Tampilan Reproduksi Sapi Rambon Betina pada Paritas yang Berbeda
Authors: Puspitasari Ika Fitri , Isnaini Nurul , Yekti Aulia Puspita Anugra , Susilawati Trinil
Published: January 2019

Penelitian ini bertujuan untuk mengetahui tampilan reproduksi sapi Rambon betina pada paritas yang berbeda. Variabel dalam penelitian ini adalah nilai Service per Conception, Calving Interval, Conception Rate dan Days Open di Kecamatan Glagah, Kabupaten Banyuwangi. Materi yang digunakan adalah 113 ekor sapi Rambon dipilih secara purposive sampling pada paritas yang berbeda. Data dianalisis dengan analisa deskriptif menggunakan nilai rataan dan standar deviasi pada nilai Service per conception, Calving Interval, Conception Rate, Days Open dan dilanjutkan menggunakan uji Kruskal Wallis. Hasil penelitian ini menunjukkan bahwa nilai Service per Conception pada paritas satu memiliki efisiensi terbaik sebesar 1,1Â±0,31 kali. Nilai Calving Interval pada paritas tiga memiliki efisiensi terbaik sebesar 374,4Â±29,02 hari. Nilai Days Open pada paritas tiga memiliki efisiensi terbaik sebesar 96,9Â±27,93 hari. Nilai Conception Rate pada paritas satu menunjukkan efisiensi terbaik yaitu sebesar 90%. Disimpulkan bahwa tampilan reproduksi sapi Rambon di Kecamatan Glagah Kabupaten Banyuwangi dalam kondisi optimal.Â
Affective Game Planning for Health Applications: Quantitative Extension of Gerontoludic Design Based on the Appraisal Theory of Stress and Coping (Preprint)
Authors: Khalili-Mahani Najmeh , De Schutter Bob
Published: January 2019

UNSTRUCTURED

User retention is the first challenge in introducing any information and communication technologies (ICT) for health applications, particularly for seniors who are increasingly targeted as beneficiaries of such technologies. Interaction with digital technologies may be too stressful to older adults to guarantee their adoption in their routine selfcare. The second challenge, which also relates to adoption, is to supply empirical evidence that support the expectations of their beneficial outcomes. To address the first challenge, persuasive technologies such as serious games (SGs) are increasingly promoted as ludic approaches to deliver assistive care to older adults. However, there are no standards yet to assess the efficacy of different genres of games across populations, or compare and contrast variations in health outcomes arising from user interface design and user experience. For the past 3 decades, research has focused either on qualitative assessment of the appeal of digital games for seniors (by game designers) or on the quantitative evaluation of their clinical efficacy (by clinical researchers). The consensus is that interindividual differences play a key role in whether games can be useful or not for different individuals. Our challenge is to design SGs that retain their users long enough to sustain beneficial transfer effects. We propose to add a neuropsychological experimental framework (based on the appraisal theory of stress and coping) to a Gerontoludic design framework (that emphasizes designing positive and meaningful gaming experience over benefit-centric ones) in order to capture data to guide SG game development. Affective Game Planning for Health Applications (AGPHA) adds a model-driven mixed-methods experimental stage to a user-centered mechanics-dynamics-aesthetics game-design cycle. This intersectoral framework is inspired by latest trends in the fields of neuroimaging and neuroinformatics that grapple with similar challenges related to the psychobiological context of an individual's behaviors. AGPHA aims to bring users, designers, clinicians, and researchers together to generate a common data repository that consists of 4 components to define, design, evaluate, and document SGs. By unifying efforts under a standard approach, we will accelerate innovations in persuasive and efficacious ICTs for the aging population.
PENGARUH TEKANAN KEUANGAN TERHADAP PENGHINDARAN PAJAK
Authors: Suprapti Eny
Published: January 2019

This study examines the effect of Growth, ROA, Leverage, Cashflow nagatif and size on taxavoidance. The testing was held 82 samples. The data obtained from the company’s annualreport website Indonesian Stock Exchange during the period 2016 and analyzed using MultipleRegresion. The research finding show that ROA negatively affect of tax evaoidance. Other findings indicate leverage positive effect on tax evoidance. ROA is a financial pressure for the company when profitability performance becomes the target that must be achieved and the researchresults show the negative direction, it can be stated that the sample company is not in a state offinancial pressure because the average ROA is lower than the interest rate on deposit. Meanwhile, leverage shows a positive influence on tax evasion. This proves that the sample companies aggressively increased the use of external funding so as to increase tax avoidance.Key words: financial pressure, tax evoidance, triangle fraud theory
MOVIMENTOS DE OCUPAÇÃO ESTUDANTIL SECUNDARISTA: NARRATIVAS VISUAIS/AUDIOVISUAIS TECIDAS EM PÁGINAS DO FACEBOOK SECONDARY SCHOOL OCCUPATION MOVEMENT: VISUAL/AUDIOVISUAL NARRATIVES ON FACEBOOK PAGES
Authors: Barros Raquel Silva
Published: January 2019

O presente artigo visa a investigar os sentidos que os jovens de escolas secundaristas do Estado do Rio de Janeiro conferem através da escolha pela criação de páginas no Facebook onde estabelecem narrativas através de vídeos e imagens no contexto do movimento de ocupação. Que fios estabelecem por meio da produção dessas narrativas em um cenário onde não apenas o físico, mas o virtual se entrelaçam? Interpelamos por uma busca ao termo ocupação bem como o sentido de espaço que se apresenta em seu plano físico e virtual já que os movimentos de ocupação tiveram como pano de fundo articulações comunicacionais mediadas por Redes Sociais digitais. Identificamos a importância das diferentes singularidades que tecem/compartilham/visualizam narrativas audiovisuais estabelecendo um grande emaranhado.
TERRITÓRIOS DE MILITÂNCIAS E PRODUÇÕES DE SUBJETIVIDADES ANDARILHAS NA AMÉRICA LATINA TERRITORY OF MILITANCY AND PRODUCTION OF WANDERER SUBJECTIVITY IN THE LATIN AMERICA
Authors: Vitor Júnior Antônio Martins , Da Silva Fábio Hebert
Published: January 2019

Propomos nesse artigo problematizar a militância. Para tanto, lançaremos mão das discussões dos modos de produção de subjetividade e de vida. Este trabalho é sustentado por viagens pela América Latina. A escolha de viajar dá-se em função da ação estratégica na produção de conexões e alianças com movimentos que contribuam com práticas de militância. A imagem do andarilho, em contraponto à do turista, à luz dos nortes geográficos e magnéticos, é subsídio importante para a discussão dos modos de viajar e exercer militância. A militância, assim, emerge da afirmação da vida produzida nos encontros pelo andarilhar.
O ATENDIMENTO EDUCACIONAL ESPECIALIZADO E A ORGANIZAÇÃO DA SALA DE RECURSOS MULTIFUNCIONAIS: QUE TERRITÓRIO É ESSE?
Authors: Braga Glaura , Prado Rosana , Cruz Osilene
Published: January 2019

Este artigo é uma pesquisa bibliográfica com objetivo de abordar a educação inclusiva e as estruturas oferecidas pelas escolas para o acolhimento à diversidade. O suporte teórico-metodológico é baseado em documentos legais, que embasam as políticas públicas de educação, além de estudos de Padilha (2007), Piovesan (2008), Meireles (2010), Pintor (2017), entre outros. Mais especificamente, apresenta um panorama sobre o Atendimento Educacional Especializado (AEE) no bojo da Política Nacional de Educação Especial na perspectiva da Educação Inclusiva e discute a proposta de efetivação das Salas de Recursos Multifuncionais relativa aos espaços, funções, atuação do profissional e público-alvo, refletindo sobre o território da educação especial concebido nas escolas regulares.
ATIVIDADES PARA O ENSINO DE ONDAS SONORAS AOS ALUNOS SURDOS: UMA PROPOSTA INCLUSIVA. ACTIVITIES FOR THE EDUCATION OF SOUND WAVES TO DEAF STUDENTS: AN INCLUSIVE PROPOSAL
Authors: Braz Ruth Maria Mariani
Published: January 2019

O projeto “Atividades para o Ensino de Ondas Sonoras” é uma proposta inclusiva que tem como objetivo possibilitar que os alunos surdos e ouvintes tenham as mesmas condições de assimilar o referido conteúdo, incluso no Currículo Mínimo de Física para o Ensino Médio. A metodologia utilizada foi o simulador PhET. Foram explorados os sentidos de tato e visão dos surdos. Esteve ainda disponível na sala de aula o apoio de uma intérprete da Língua Brasileira de Sinais. Foi neste contexto que os alunos puderam aprender através da exploração e da descoberta. A proposta foi aplicada com êxito entre alunos de uma escola pública, inseridos em diferentes séries dos Ensinos Fundamental e Médio. Tivemos como resultado o sucesso dos alunos surdos nesta aprendizagem, bem como o neologismo de dois sinais em LIBRAS: um para ultrassom e o outro para infrassom.
FORMAÇÃO ONLINE SOBRE DROGAS PARA DOCENTES NA PERSPECTIVA DA REDUÇÃO DE DANOS: O PONTO DE VISTA DOS CURSISTAS. ONLINE EDUCATION ON DRUGS FOR TEACHERS IN THE PERSPECTIVE OF DAMAGE REDUCTION: THE VIEW OF CURSISTS
Authors: Figueiredo Francisco José , Monteiro Simone Souza
Published: January 2019

Pesquisas revelam que drogas circulam entre os jovens, mas diante do despreparo dos professores, o tema não é abordado nas escolas. Este estudo descreve um curso de formação online sobre drogas para docentes - informada pela perspectiva da Redução de Danos como modelo crítico e emancipatório - e as atividades educativas desenvolvidas na etapa final da formação. Apesar de ainda haver dúvidas sobre a concepção de redução de danos, os cursistas entrevistados promoveram espaços de diálogo e aprendizagem sobre drogas com suas turmas. Os resultados sugerem que o curso pode contribuir para a abordagem do tema entre estudantes.
Potencjał produkcji biogazu rolniczego w województwie pomorskim i jego wykorzystanie
Authors: Podstawka Marian , Bieńkowska Wioletta , Gołasa Piotr
Published: January 2019

The purpose of this paper was to determine the production capacity of agricultural biogas in districts of Pomorskie NUTS 2 region. The data comes from the Agency for Restructuring and Modernization of Agriculture. It refers to the number of farms in various municipalities that in 2011 met certain criteria. It was revealed that the most favourable conditions for the construction of agricultural biogas have been observed in the north-western and south-eastern parts of the region.
The effect of beta-glucosidase supplementation on enzymatic hydrolysis of cellulose in hydrothermally pretreated sugar beet shreds
Authors: Antov Mirjana , Fistes Aleksandar
Published: January 2019

Sugar beet shreds were pretreated by hydrothermal procedure to investigate
the effect of beta-glucosidase supplementation at different substrate
loading on the rate of cellulose hydrolysis. Cellulose in the hydrothermally
pretreated substrate was more efficiently hydrolyzed by enzymes than in
untreated material, resulting in more than two times higher release of
reducing sugars. In the investigated range of solids load, supplementation
of fungal cellulases cocktail by beta-glucosidase increased production of
reducing sugars from substrates, while 0.25 U/g was sufficient to achieve
the highest effect under applied conditions.
Microbiological quality of fresh vegetable salads from the Novi Sad market
Authors: Cvetkovic Dragoljub , Pavlovic Dragan , Ranitovic Aleksandra , Markov Sinisa
Published: January 2019

Increased consumption, big production units and very efficient delivery
service networks of fresh vegetables and salads caused a higher number of
foodborne illnesses in the last two decades all over the world. In this
study 15 fresh vegetable salads from different marketplaces in Novi Sad were
tested by reference microbiological methods (detection of Salmonella spp.,
enumeration of Listeria monocytogenes, mesophilic aerobic bacteria, yeasts
and molds, sporogenic mesophilic aerobic bacteria, sporogenic
sulfite-reducing bacteria, Bacillus cereus, Enterobacteriaceae, Escherichia
coli and coagulase positive staphylococci). Salmonella spp. was found in one
sample which, according to the safety criteria for such a product (if
treated as ready-to-eat), was considered to be microbiologically unsafe. The
number of Listeria monocytogenes in all tested samples was <100 cfu/g, which
is a satisfactory result according to the safety criteria. E. coli was
detected in only one sample, and the number of Enterobacteriaceae was in the
range from 4.4 to 6.9 log CFU/g. The isolated Enterobacteriaceae strains
were identified as Enterobacter cloacae, Klebsiella pneumoniae ssp.
pneumoniae and Citrobacter spp.
Influence of the geometry on the riser gas holdup in an external-loop airlift reactor: empirical and neural network modelling
Authors: Lukic Natasa , Jokic Aleksandar
Published: January 2019

Experimental studies on the effect of geometrical characteristics
(restriction orifice free area and sparger configuration) on the riser gas
holdup of an external-loop airlift reactor have been conducted in this
paper. The impact of the addition of non-coalescing media, such as
n-butanol, was also investigated. In general, the decrease in the
restriction orifice free area led to a substantial increase (up to 90%) in
the riser gas holdup. The addition of n-butanol effected gas holdup to a
lesser extent, as it increased the gas holdup in the range of 4-15%,
depending on the restriction orifice free area. On the other hand, the
impact of the sparger type was observed only at lower gas velocities, for
which the sinter plate increased the gas holdup up to 20% in comparison to
the single orifice. The paper also presents an empirical correlation for the
estimation of the riser gas holdup with an average relative error of 7%.
Finally, a neural network model with an average relative error of 2.4% was
proposed.
Whey desalination using polymer and inorganic membranes: Operation conditions
Authors: Myronchuk Valerii , Zmievskii Yurii , Dzyazko Yuliya , Rozhdestvenska Ludmila , Zakharov Vladimir
Published: January 2019

Electrodialytic desalination of cheese whey was carried out using a pair of
polymer cation exchange (Nafion 117) and inorganic membranes. The ceramic
separator was modified with nanocomposite containing hydrated zirconium
dioxide and basic bismuth nitrate. This amphoteric filler provides anion
exchange ability of the composite membrane. This property is realized when at
least one side of the membrane is in contact with an acidic solution. Ion
transport through the membranes was shown to be determined by current, whey
acidity, and also by composition of the solution in the concentration
compartment of the electrochemical cell. It was shown that whey desalination
occurred under overlimiting current. Acidification of whey and decrease of
the acid content in the concentrate suppress ion transport. The
electrodialysis of whey and nanofiltration permeate allowed removal of up to
80% of the mineral components in 5 h and 40 min, respectively. Preliminary
ozonation of the permeate increased the rate of desalination.