bluuebunny/crossref_metadata_2025 huggingface dataset:
RELATIONSHIP BETWEEN PARAMETERS OF THE LUMBAR FACET JOINTS IN A LONG-TERM POSTOPERATIVE OUTCOME
Authors: Byvaltsev Vadim Anatol'evich , Kalinin Andrei Andreevich , Okoneshnikova Alyona Konstantinovna , Pestryakov Yuri Yakovlevich , Basankin Igor Vadimovich
Published: September 2018

ABSTRACT Objective: To analyze the impact of the relationship between tropism and angulation of the lower lumbar facet joints on a remote clinical outcome after dynamic and rigid surgical interventions. Methods: Patients with degenerative diseases of the lower lumbar spine were subdivided into three groups, according to the method of surgical treatment: 1) (n=48) the use of an artificial prosthesis intervertebral disc (IVD); 2) (n=42) the use of interbody fusion combined with transpedicular and transfacet stabilization; 3) (n=51) the use of interbody fusion and bilateral transpedicular stabilization. Analysis was performed of the remote clinical parameters and neuroimaging characteristics before the operation was performed. Results: When analyzing clinical and instrumental parameters, a significant correlation was found between the long-term outcomes of surgical treatment on the VAS and Oswestry scales and the neuroimaging data on angulation and tropism of the facet joints (FJ). Conclusions: The data obtained testify to the importance of preoperative diagnosis of tropism and angulation of the lower lumbar facet joint, which enables differentiated surgical tactics to be selected, and remote clinical outcomes to be optimized. In the presence of neuroimaging parameters of Facet Joint angulation of less than 600, regardless of the presence of tropism, it is possible to perform total arthroplasty of IVD. When neuroimaging parameters of Facet Joint angulation of more than 600 are detected, rigid stabilization of the operated segment is recommended, while in the absence of tropism of Facet Joints, a contralateral transfacetal fixation is possible; in the presence of tropism, it is expedient to perform bilateral transpedicular stabilization. Level of Evidence II; Prognostic Studies—Investigating the Effect of a Patient Characteristic on the Outcome of Disease.
COMPLICATIONS OF SURGICAL TREATMENT OF LUMBAR STENOSIS IN THE EARLY POSTOPERATIVE PERIOD
Authors: Basankin Igor Vadimovich , Porkhanov Vladimir Alexeevich , Afaunov Asker Alievich , Kuzmenko Alexander Veniaminovich , Shapovalov Vladimir Konstantinovich
Published: September 2018

ABSTRACT Objective: To analyze the structure of degenerative lumbar stenosis surgical treatment complications and to analyze their effect on the results and indications for revision operations. Methods: Between 2009 and 2013, 513 patients with lumbar stenosis of degenerative etiology were surgically treated. There were 205 men, 308 women, aged 23 to 74 years. The main clinical manifestations were persistent compression radiculopathy, chronic pain in the back and lower limbs, and difficulty walking. The intensity of the pain was assessed by the VAS. At the time of hospitalization, VAS was 55-90 points. Results: Of the 513 operated patients, 65 (12.67%) had complications in the early postoperative period (up to three months after the operation); intraoperative complications occurred in 26 (5.1%) patients; intraoperative dura mater injury occurred in 24 (4.67%); pulmonary embolism (PE) occurred in 2 (0.39%) patients; 39 patients had early postoperative complications; acute radiculopathy occurred in 22 patients (4.28%); and 17 patients (3.31%) had surgical wound complications. Conclusions: Liquorrhea, postoperative hematomas and acute radiculopathy had no negative effect on the results of treatment in any of the cases. In the early postoperative period, 4 (0.77%) deaths were recorded intraoperatively and in 2 (0.39%) cases, intraoperative PE occurred. Two cases (0.39%) resulted in sepsis and multiple organ failure. In eight (1.55%) patients, the results of the treatment were unsatisfactory: in 4 (0.77%) cases due to death, and in a further 4 (0.77%) due to elimination of the system by the spinal column as a result of suppuration. Level of Evidence IV; Therapeutic studies - Investing the results of treatment.
Mobilidade estudantil internacional: a experiência de estudantes de graduação em Enfermagem
Authors: Guedes Glauteice Freitas , Cavalcante Inara Mariela da Silva , Püschel Vilanice Alves de Araújo
Published: September 2018

RESUMO Objetivo Compreender as experiências vivenciadas pelos estudantes de graduação da Escola de Enfermagem da Universidade de São Paulo na mobilidade estudantil internacional. Método Estudo transversal, descritivo, com abordagem qualitativa, realizado entre fevereiro e julho de 2017. Os dados foram coletados por meio de uma entrevista semiestruturada e submetidos à análise de conteúdo. Resultados Participaram do estudo 22 estudantes. Na análise das entrevistas, emergiram cinco categorias analíticas: Dimensão das Relações Interinstitucionais, Dimensão Pessoal, Dimensão Profissional, Dimensão Acadêmica e Dimensão Cultural. Conclusão São muitas as vantagens que o intercâmbio internacional pode trazer à formação profissional. Considera-se necessário maior investimento governamental e institucional, mas com planejamento mútuo e acompanhamento das instituições, de forma que contribua para o desenvolvimento da Enfermagem e do País.
Chemical composition and antimicrobial activity of Myristica fragrans & Elettaria cardamomum essential oil
Authors: Özkan Osman Emre , Olgun Çağrı , Güney Betül , Gür Mahmut , Güney Kerim , Ateş Saim
Published: September 2018

Aim of study: The objectives in this study were to determine the chemical composition and antimicrobial activity of the essential oils from nutmeg (Myristica fragrans) and cardamom (Elettaria cardamomum).Material and Methods: The essential oil was obtained from nutmeg and cardamom seeds through hydrodistillation method. The chemical composition of nutmeg and cardamom essential oil was analyzed by GC-MS. The antimicrobial activity of essential oil was investigated against Bacillus subtilis DSMZ 1971, Candida albicans DSMZ 1386, Enterococcus faecalis ATCC 29212, Enterobacter aerogenes ATCC 13048, Enterococcus durans, Enterococcus faecium, Escherichia coli ATCC 25922, Klebsiella pneumoniae, Listeria monocytogenes, Listeria innocua, Pseudomonas aeruginosa DSMZ 50071, Pseudomonas fluorescence P1, Salmonella enteritidis ATCC 13076, Salmonella infantis, Salmonella kentucky, Salmonella typhimurium SL 1344, Staphylococcus aureus ATCC 25923 and Staphylococcus epidermidis DSMZ 20044 with minimum inhibitory concentration (MIC) method.Main results: GC-MS analyzes shows that γ-terpinene (19.16%), (-)-terpinen-4-ol (14.08%), α-pinene (6.75%), myristicin (6.18%), β-pinene (4.85%), sylvestrene (4.72%), elemicin (4.68%) and safrole (4.17%) identified in nutmeg essential oil. Also, α-terpinyl acetate (34.55%), eucalyptol (24.91%), (-)-terpinen-4-ol (10.63%), linalool (7.69%) and neryl butyrate (6.58%) compounds identified in cardamom essential oil as major compounds. Nutmeg and cardamom essential oil showed an antimicrobial activity against almost all test microorganisms.Research highlights: This study suggests that nutmeg and cardamom essential oil may be useful in the medicinal application and food industry as a preservative.
Study on peripheral blood miR-155 expression in patients with type 2 diabetes mellitus and its relationship with vascular complications v1
Authors: Guo Liting
Published: September 2018

Objective: To evaluate the expression of miR-155, nuclear factor kappa B (NF-κB) and soluble intercellular adhesion molecule-1 (sICAM-1) in the peripheral blood of patients with type 2 diabetes mellitus (T2DM) and assess its relationship with diabetic vascular lesions. Methods: A total of 165 T2DM patients and 60 healthy patients were included. Patients were divided into two groups: a simple T2DM group and a T2DM with vascular lesion group. The latter was further divided into a microvascular lesion group, a macrovascular lesion group and a microvascular combined with macrovascular lesion group. Albuminuria levels were divided into three groups as follows: <30 mg / 24 h, normal albuminuria group (NAU group); 30-300 mg / 24 h, microalbuminuria group (MAU group); and ≥300 mg / 24 h, large albuminuria group (LAU group). Levels of peripheral blood miR-155, NF-κB, and sICAM-1 were detected by RT-PCR[SE . Results: ①Compared with that in the control group, the expression of miR-155, NF-κB, and sICAM-1 in the T2DM group was significantly increased [(1.00±0.12) vs. (1.82±0.71), (1.04±0.33) vs. (2.28±0.66), (1.03±0.30) vs. (1.88±0.80), respectively; P<0.05]. ②The levels of miR-155, NF-κB, and sICAM-1 were significantly higher in the T2DM vascular lesion group than in the simple T2DM group [(1.95±0.73) vs. (1.34±0.29), (2.40±0.65) vs. (1.65±0.16), (2.01±0.77) vs. (1.07±0.41), respectively; P<0.05]. ③The expression of miR-155 in the microvascular combined with macrovascular lesion group was higher than that in the macrovascular lesion group [(2.36±0.61) vs. (1.77±0.59); P<0.05], and the level of NF-κB in the former group was significantly higher than those in the microvascular and macrovascular lesion groups (P<0.05). ④Compared with that in the NAU group, the level of miR-155 was significantly increased in the MAU and LAU groups [(1.04±0.20) vs. (1.41±0.49) vs. (2.64±0.52), respectively; p<0.05], and the miR-155 level in the LAU group was higher than that in the MAU group (P<0.05). ⑤Pearson correlation analysis showed that miR-155 was positively correlated with NF-κB and sICAM-1 (R=0.259, 0.67; P<0.01). Conclusions: miR-155 expression was increased in T2DM patients and vascular lesions, consistent with the increasing trends observed for NF-κB and sICAM-1. These findings suggest that miR-155 may be involved in the occurrence and development of diabetic chronic vascular disease.
Study on the efficacy of insulin pump combined with dapagliflozin in Chinese patients with type 2 diabetes v1
Authors: Guo Liting , Gao Zhihong , Ge Huanqi
Published: September 2018

Objective: To observe the efficacy of insulin pump combined with dapagliflozin and insulin pump alone in the treatment of patients with type 2 diabetes. Methods 87 cases of type 2 diabetes were randomly divided into treatment group (55 cases) and observation group (32 cases). On the basis of strict control of diet and exercise, the treatment group was given dapagliflozin 10mg/d+ insulin pump + Saxagliptin 5mg/d or Liraglutide 1.2mg/d and the observation group was treated with insulin pump + Saxagliptin 5mg/d or Liraglutide 1.2mg/d. After 12 weeks of treatment, fasting blood glucose, postprandial 2h blood sugar and glycated hemoglobin were measured, the dosage of insulin was calculated, the weight and blood pressure were measured, and the incidence of hypoglycemia and urinary tract infection was observed. Results 1) After 12 weeks treatment, the fasting blood glucose, postprandial 2h blood sugar and glycated hemoglobin decreased significiantly in the treatment group and the observation group [(-4.51 ± 1.93) mmol/l, (-8.45 ± 3.17) mmol/l, (-2.42 ±1.07)% and (-4.29 ± 1.25) mmol/l, (-8.20 ± 3.65) mmol/l, (-2.41 ± 1.34)%]. 2) After 12 weeks treatment, the systolic pressure and diastolic pressure in the treatment group and the observation group decreased respectively [(-12.69 ± 16) mmHg, (-6.96 ± 9) mmHg and [(-2.34 ± 9.90) mmHg, (-2.06 ± 11.09) mmHg], the decrease degree between the two groups were significant difference (all P<0.05). 3) Weight loss after 12 weeks in the treatment group was (-4.00 ± 4.22) kg, while the weight in observation group slightly increased by (0.19 ± 1.61) kg (P<0.05). 4) The average daily insulin dosage in the treatment group and the observation group decreased after 12 weeks (-24.53 ± 12.48) IU and (-4.90 ± 10.87) IU respectively (P<0.05) and 18 cases of diabetes were discontinued insulin in the treatment group and 5 cases of diabetes were discontinued insulin in the observation group (P < 0.05). 5) There was 1 case hypoglycemia in the treatment group and 1 case hypoglycemia in the observation group. No urinary tract infection and ketosis were occurred in the two groups. Conclusion Combination insulin pump and dapagliflozin to treat type 2 diabetes can effectively reduce the blood sugar, weight, blood pressure, and insulin doses, and do not increase the risk of hypoglycemia.
ACSL4 gen polimorfizminin (rs7886473) metabolik sendrom ve lipid düzeyleri üzerine etkisi
Authors: VURGUN Eren , DİKER İrem Yağmur , ÇOBAN Neslihan , GEYİK Filiz , GÜVEN Gamze , ERGİNEL ÜNALTUNA Nihan
Published: September 2018

Amaç: Lipid metabolizması üzerinden obezite ve metabolik sendromla ilişkisi olabileceğini düşündüğümüz ACSL4 geninin sık görülen rs7886473 A>G polimorfizminin Türk toplumunda metabolik sendrom ve lipid düzeyleri üzerindeki etkisini araştırmayı amaçladık.Gereç ve Yöntem: Çalışmamıza, Türkiye genelinde takip edilen ve modifiye edilmiş NCEP ATPIII Metabolik Sendrom tanı kriterlerine göre 556 metabolik sendrom olan ve 520 metabolik sendrom olmayan erişkin birey dahil edildi. Metabolik sendrom olan ve olmayan bireylerin ACSL4 gen polimorfizmi Roche Light Cycler 480 Real-Time PCR ile genotiplendi ve karşılaştırıldı.Bulgular: Metabolik sendrom olan ve metabolik sendrom olmayan bireyler arasında ACSL4 rs7886473 genotip dağılımları arasında anlamlı bir farklılık bulunmadı. Tüm erkeklerin ACSL4 rs7886473 polimorfizmine göre serum total kolesterol, HDL, LDL ve trigliserid düzeyleri karşılaştırıldığında; GG ve AA genotipleri arasında anlamlı bir farklılık bulunmadı. Benzer şekilde tüm kadınlarda da anlamlı farklılık bulunmadı.Sonuç: Bu çalışma, ACSL4 geni açısından incelemiş olduğumuz rs7886473 gen polimorfizminin metabolik sendrom ve serum lipid düzeyleri üzerine etkisi olmadığını gösterdi. Ancak çalışmamızda incelenmiş olan ACSL4 geninde yaygın görülen yalnızca bir polimorfizmdir. Bu durum ACSL4 geninin lipid metabolizması ve/veya metabolik sendrom üzerine etkili olmadığını değerlendirmek için tek başına yeterli değildir.
Quality of life and sexual life in women with advanced stage pelvic organ prolapse
Authors: AVCIBAY VURGEÇ Burcu , KIZILKAYA BEJİ Nezihe
Published: September 2018

Purpose: This study aims to evaluate women with pelvic organ prolapse in terms of the risk factors and identify the effects of pelvic organ prolapse on quality of life and sexual function. Materials and Methods: Target population of the study was women who applied to the gynecology polyclinics in a university hospital and maternity and children hospital. The study was completed with 110 control and 81 case group participants. The data were collected through Personal Identification Form, Pelvic Floor Distress Inventroy-20 (PFDI-20), Prolapse Quality of Life Scale (P-QOL), Pelvic Organ Prolapse / Urinary Incontinence Sexual Function Questionnaire (PISQ-12) and Female Sexual Function Inventory (FSFI).  Results: Study results show that as pelvic floor dysfunction increases, quality of life decreases and sexual function is affected negatively. The difference in the general mean scores of questionnaires life quality and sexual dysfunction between the case and control groups was found to be statistically significant. POP prevalence decreases 1.6 times with the decrease in the number of pregnancies; it decreases 3.5 times with the decrease in the number of deliveries; and assisted delivery increases 2.8 times and increases 5.8 times if there is family history.Conclusion: Given the relationship between pelvic floor dysfunction and quality of life and sexuality it is possible to say that this is not only a medical problem but also a social problem. In this regard, it is important that both health professionals and women have prior knowledge of the risks about in terms of reducing the risk of encountering POP.
Hemşirelik öğrencilerinde Beyin Göçüne Yönelik Tutum Ölçeği geliştirilmesi: güvenirlik ve geçerlik çalışması
Authors: ÖNCÜ Emine , SELVİ Hüseyin , K. VAYISOĞLU Sümbüle , CEYHAN Halil
Published: September 2018

maç: Bu çalışmanın amacı, hemşirelik öğrencilerinin beyin göçüne ilişkin tutumlarını belirlemeye yönelik bir ölçek geliştirmektir. Gereç ve Yöntem: Araştırma 01.03.2018- 25.04.2018 tarihleri arasında yapılmıştır. Çalışmaya hemşirelik lisans programı 1- 4. sınıflarda okuyan ve amaçlı örnekleme yöntemiyle belirlenen 423 öğrenci katılmıştır. Araştırmanın verileri 5’li likert tipinde 35 madde içeren denemelik ölçek formdan elde edilmiştir. Bulgular: Ölçeğin faktör analizine uygunluğu “Kaiser-Meyer-Olkin katsayısı” ve “Barlett Sphericity Testi” ile değerlendirilmiştir. Açımlayıcı faktör analizi sonucunda 19 maddenin ölçekten çıkarılmasıyla kalan 16 maddelik taslak ölçek, toplam varyansın % 51’ini açıklamaktadır. Maddeler “itici ve çekici faktörler” olarak iki bileşen altında toplanmıştır. Ölçeğin faktör yükleri 0.93 ile 0.37, düzeltilmiş madde- toplam korelasyonları ise 0.81 ile 0.34 arasında değişmektedir. Ölçeğin Cronbach Alfa güvenirliliği, bütüne ilişkin 0.91 ve alt bileşenlerine ilişkin 0.88 ve 0.86’dır. Ölçeğin geçerlilik kanıtlarını arttırmak için 396 hemşirelik öğrencisinden toplanan yeni verilerle yapılan doğrulayıcı faktör analizi sonuçları, faktör yapısının veriyle uyumlu olduğunu ortaya koymuştur (χ2/ sd= 3.68, RMSEA=0.083, CFI=0.97, NFI=0.96, GFI=0.89, AGFI= 0.86).  Sonuç: Hemşirelik öğrencilerinin beyin göçüne ilişkin tutumunu değerlendirmek üzere geliştirilen ölçeğin güvenilir ve geçerli bir ölçek olduğu sonucuna varılmıştır. Ölçek daha farklı örneklem gruplarında da denenmelidir.
Effect of laparoscopic hysterectomy on sexual function and quality of life: 12-month follow-up results
Authors: SUKGEN Gökmen , ELLİBEŞ KAYA Aşkı
Published: September 2018

Purpose: The purpose of this study is to investigate the effect of laparoscopic hysterectomy for benign reasons on the quality of life and sexual function of the patients with 12-month follow-up results.Materials and Methods: This prospective cohort study included 28 patients who had a laparoscopic hysterectomy. The participants` quality of life and sexual function level was measured with the Female Sexual Function Index (FSFI) and Short Form 36 Quality of Life Scale (SF-36) before and the first year after the operation. Results: There were no significant differences on the participants` sexual function scores between preoperation, and the first year after the operation. Although there was an improvement in all of the sub-domain scores, only sexual desire scores decreased after the operations, but these results were not statistically significant. However, quality of life scores, in all sub-domains, significantly increased after the surgery except the vitality. The vitality scores of the participants decreased.Conclusion: There is no effect of laparoscopic hysterectomy on sexual functioning, and there is a positive effect on the quality of life in the 12-month follow-up.
Waiting for Me: Exploring Autoethnodrama
Authors: Shenfield Robyn Taylor
Published: September 2018

I In this paper, I explore autoethnodrama through the writing of a performative play text. I move between the tandem voices of my current self (30-year-old graduate student and drama teacher) and my past self (14-year-old Year 9 student) as I grapple with new theoretical ideas and academic forms of writing, as well as my place within the educational and scholarly worlds. Along with intertextual references to Waiting for Godot, my voices move between the conversational, the scholarly, the absurd and the poetic, as I try to capture a dream-like quality, perhaps reminiscent of my subconscious at a point in time. I negotiate fragments of identity and try to reconcile new theoretical concepts with practice as I attempt bring my past into the present and uncover purpose, with apologies to Beckett.
Is There a Definition? Ruminating on Poetic Inquiry, Strawberries and the Continued Growth of the Field
Authors: Vincent Adam
Published: September 2018

Over the last ten years, Poetic Inquiry (PI) has proven itself as an emergent arts-based research methodology. It has gained greater acceptance in the larger community of qualitative research due in large part to the hundreds of published studies that employ the writing or analysis of poetry as a major focus of the research process (Finley, 2003; Prendergast, Leggo & Sameshima, 2009; Prendergast & Galvin, 2012). However, despite this greater acceptance and increase in studies found in the literature, there has not been a critical contemporary exploration of the history, theory and method of PI that could lend itself to defining what the method is, for those unfamiliar with it. This article provides a summary of PI as it exists in the literature today. This includes surveying the rhizomatic history of the method, exploring debates around who should or should not use the method and conversation around the current uses of PI in qualitative research.
Editorial Vol. 3 No. 2
Authors: Conrad Diane , Leavy Patricia
Published: September 2018

An introduction to Volume 3, Number 2, from co-Editorsi-in-Chief Dr. Diane Conrad and Dr. Patricia Leavy.
Proses Pemodelan Saintifik pada Miskonsepsi Mekanika Kuantum
Authors: Hermawan Dian Wahid
Published: September 2018

The process of misconceptions about the concepts of quantum physics in students needs to be comprehensively analyzed. This is because most of the revision process of student misconception is done directly by simply replacing the wrong explanation with the correct explanation. While to understand the theory and hypothesis of quantum physics phenomena requires abstract physics model and formal mathematical language. Modeling done by the mind sometimes does not require image image in the brain. As between the wave function and the particle position associated with the mathematical model. The misconceptions in quantum physics occur because of the wrong scientific conceptual modeling process. The scientific conceptual model is divided into four dimensions: domain, composition, structure and organization. Analysis of the misconception process modeling using these dimensions will be done on the phenomenon of quantum physics. The misunderstanding of the definition of the wave function concept Ѱ (x) occurs due to the incorrect dimensions of the model's interactive structure. While the misconception of the concept of quantity of energy and the relationship of wave function with probability, occurs in the dimension of the behavioral structure of the model. In the concept of position measurement and momentum of quantum systems, errors occur in both structures.
Tinjauan Filosofis tentang Fungsi Pendidikan dalam Hidup Manusia
Authors: Haderani Haderani
Published: September 2018

Knowladge is every things important for human. Since born feel this important knowladge. Some factor to get knowladge. Some way is intern factor and extern factor. Need full humanity make human is learning to get knowladge. Education is way the beter than to take knowladge because standart education is well used knowladge for suistainblty for human. Human this name perfect because with the abilty human can make knowladge wise and with norm the everyday life.
Current approaches in gestational diabetes mellitus
Authors: PEKER Ahmet , YARKICI Hakan , AKAR Harun
Published: September 2018

Gestational
diabetes mellitus (GDM) is one of the most common medical complications in
pregnancy and has become a global public health issue in terms of causing fetal
and maternal morbidity and mortality in short- and long-term. The number of
cases of GDM all over the world has been increasing day by day and they include
risks for mother and baby health compared to healthy pregnancies. GDM screening
and diagnostic phase has complete different approaches and there is no common
consensus. Once GDM is diagnosed, pharmacologic treatment can be necessary in
addition to strict blood sugar follow-up, regular exercise, and diet regulation.
In postpartum period, medical monitoring is also necessary due to increased
risk of diabetes mellitus in women with GDM. In this paper, we will also
discuss approaches suggested in the GDM in the context of current guidelines
and literature.
Elektromanyetik Navigasyon Diyagnostik Bronkoskopi (ENB)
Authors: Kanbur Metin Serda , Tezel Çağatay
Published: September 2018

Bilgisayar teknolojisindeki ilerlemeler, spiral toraks bilgisayarlı (BT)
tomografisinden elde edilen verilerin kullanılarak, trakeobronşiyal ağacın
sanal gerçeklikteki görüntülerinin oluşturulmasına imkan tanımaktadır. Periferik
pulmoner lezyonlar yapılan görüntüleme tekniklerinde raslantısal olarak yaygın
şekilde görülmektedir.  Bu lezyonların
giderek artan sıklıkta görülmesi, direk grafilerden üç kat daha duyarlı olan BT
kullanımını artırmaktadır. Yeni bir bronkoskopik teknik olan elektromanyetik navigasyon diyagnostik
bronkoskopi (ENB), periferal pulmoner lezyonlarda doğru tanı oranını artırmada
gelecek vadeden bir yöntem olmaya başlamıştır. Bu lezyonların tanısında yaygın
olarak kullanılan BT eşliğinde yapılan ince iğne aspirasyon biyopsisi (TTİAB),
malign lezyonlarda %90 sensitiviteye sahipken %20 ila 30 oranında yanlış negatiflik
oranına sahiptir. Ayrıca bu yöntem yaklaşık %25 oranında minör pnömotoraksa yol
açmaktayken, %5 oranında göğüs tüpü drenajına gerek duyulmaktadır. Bronkoskopik
tekniklerin, transtorasik biyopsiye göre ana avantajı daha üstün bir güvenliğe
sahip olmasıdır. Elektromanyetik navigasyon diyagnostik bronkoskopi (ENB), ek
floroskopik yöntem kullanmadan, özellikle inoperabl hastalarda erken tanı
doğruluğunu artırmada faydalı olabilir.
KONSEP KEPEMIMPINAN BERBASIS BUDAYA ISLAM JAWA
Authors: Mulyono Mulyono
Published: September 2018

Leadership concept based on Javanese-Islamic culture, one of them stem from Wali Songo representing leadership concept having integrity in character such as the king title of Demak: Sayyidin Panata Gama, Senapati Ing Ngalogo, Khalifatullah Fil-Ardh (Most powerful in ruling the religion, commander in battlefield, the leader on earth). The concept of leadership having integrity for Javanese society 
represents a solid figure in religion, as a moslem scholar, war lord and king as well. The richness of Javanese cultures
have leadership values represented in those criteria through brief expression which is full of meaning. In democratic era  and local autonomy in this time, this concept of leadership based on the values of Javanese culture is significant to study as a means to accomodate dynamics of plural society of  Nusantara, so that it has bargaining position of leadership in modern Indonesia.

 

Konsep kepemimpinan berdasarkan budaya Jawa-Islam, salah satunya berasal dari Wali Songo yang mewakili konsep kepemimpinan yang memiliki integritas dalam karakter seperti gelar raja Demak: Sayyidin Panata Gama, Senapati Ing Ngalogo, Khalifatullah Fil-Ardh (Paling berkuasa dalam memerintah agama, komandan di medan perang, pemimpin di bumi). Konsep kepemimpinan yang memiliki integritas untuk masyarakat Jawa mewakili sosok yang solid dalam agama, sebagai seorang ulama, raja dan pimpinan perang juga. Kekayaan budaya Jawa memiliki nilai-nilai kepemimpinan yang diwakili dalam kriteria tersebut melalui ekspresi singkat yang penuh makna. Dalam era demokrasi dan otonomi daerah saat ini, konsep kepemimpinan yang didasarkan pada nilai-nilai budaya Jawa signifikan untuk dipelajari sebagai sarana untuk mengakomodir dinamika masyarakat plural Nusantara, sehingga memiliki posisi tawar kepemimpinan Indonesia modern.
Potensi Salep Ekstrak Daun Sirih Merah Terhadap Profil Eritrogram Sebagai Terapi pada Luka Miasis (THE EFFECT OF RED BETEL LEAF EXTRACT OINTMENT IN ERYTHROGRAM PROFILES AS THERAPY IN MYASIS WOUND)
Authors: Widhyari Sus Derthi , Wientarsih Ietje , Mustika Aulia Andi , Wardhana April Hari , Darmakusuma Dodi , Sutardi Lina Noviyanti , Bintang Muhammad
Published: September 2018

The objectives of this research was to examine the efficacy of red betel extract ointment to eritrogram profiles in infected sheep myiasis. Fifteen female sheeps were divided into five treatments, which were sheep without wound, treated with asuntol 2%, without any treatment,with red betel leaf extract ointment 2% and 4 %. Three incision wounds were made on the sheep’s back, 50 larvae given to every wounds to four treatment, except the healthy sheep (K). Blood was taken on the 0, 3th and 7th to determine erythrocytes counts, hematocrit values (PCV) and hemoglobin levels (Hb). The result showed that oitment of red betel leaf extract do not change the erythrogram profiles. The administration of red betel leaf extract ointment 4% has better eritrogram profiles than 2% Oitment of red betel leaf extract can be used as myasis therapy.
Uji In Vitro Gabungan Ekstrak Boesenbergia pandurata, Solanum ferox, Zingimber zerumbet terhadap Bakteri Patogen pada Ikan Nila (IN VITRO TEST OF CONCOCTION PLANT EXTRACTS OF BOESENBERGIA PANDURATA, SOLANUM FEROX, ZINGIMBER ZERUMBET
Authors: Hardi Esti Handayani , Saptiani Gina , Nurkadina Nurkadina , Kusuma Irawan Wijaya , Suwinarti Wiwin
Published: September 2018

The aim of this study was to evaluate the antibacterial activity of ethanol concoction (mixed extract) of three herbs plants, such as: Boesenbergia pandurata, Solanum ferox and Zingimber zerumbet against Aeromonas hydrophila, Pseudomonas sp. and both bacteria. The Plant extracts were obtained by using ethanol and the concentration of the extract was 600 mgL-1 of B. pandurata, 900 mgL-1 of S. ferox and 200 mgL-1 of Z. zerumbet. The inhibition zone was measured after 6, 12, 18, 24 h incubation at 30o C. The ratios of concoction S. ferox and B. pandurata (for 100 mL solution) were 90:10; 80:20; 70:30; 60:40; 50:50; 40:60; 30:70; 20:80; 10:90. The same ratios were made on the concoction of S. ferox and Z. zerumbet. The concoctions of S. ferox and B. pandurata in the ratio of 50:50 and 60:40, and the concoction of S. ferox and Z. Zerumbet with ratio 60:40 had higher antibacterial activity against A. hydrophila single isolate compared to the other concoctions. Furthermore, the concoction extract of S. ferox and B. pandurate 50:50 and the combined of S. ferox and Z. zerumbet ratio 50:50 and 90:10 were the best combination to inhibit the growth of a single bacterium Pseudomonas sp. The combined S. ferox and B. pandurata ratio 50:50; 10:90 and S. ferox mixed with Z. zerumbet ratio 50:50 and 40:60 were the best combination against the combined bacteria between A. hydrophila and Pseudomonas sp. The conclusion of this research was the combined extract of S. ferox and B. pandurata and S. ferox with Z. zerumbet are effective to suppress the growth of single or combination of A. hydropila and Pseudomonas sp.
WILLOW TRIANDRA (SALIX TRIANDRA L.): PROSPECTS AND OPPORTUNITIES FOR USE IN MEDICINE AND PHARMACY
Authors: Sannikova E. G. , Popova O. I. , Kompantseva E. V.
Published: September 2018

One of the most promising plants for expanding the range of medicines having astringent and anti-inflammatory effects are various species of willow, which have been used in folk medicine for a long time and now arewidely appliedin the composition of various biologically active additives to food both abroad and in Russia. Currently, in medical practice, white willow (Salix alba L.) is mainly used. Numerous species of willow that grow and are widely cultivated in the Russian Federation have not yet been widely used in medicine.

The aim of the studyis to summarize the literary data about the expansion habitat, the content of biologically active substances and the possibility of harvesting raw materials of willow triandra (Salix triandra L.) and its use in medicine and pharmacy.

Materials and methods.The object of the study is willow triandra (S. triandra L.) widespread in the Russian Federation. The study was conducted using search and information and library databases (eLibrary, PubMed, CyberLeninka, ResearchGate).

Results and discussion.Willow triandra (Salix triandra L.) is a perennial dioecious plant, belonging to the Salicaceae family (Willow), Amygdalinae section. The natural habitat of willow triandra is predominantly forest and forest-steppe zones of the European and Asian continents. Eastern Europe is the geographical center of the growth of willow triandra, where it occurs throughout the territory. In Russia, willow triandra occupies almost the whole of its European part, in the North extends as far as the Petrozavodsk-Vologda-Kirov line, and the North Caucasus, it can be found on the territory of Western and Central Siberia. This suggests the idea that plant resources of willow triandra are significant. The possibility of cultivation of willow triandra in various edaphic-phytocenotic conditions is noted, since it is most easily subjected to vegetative propagation. It has been pointed out that willow triandra, like other willow species, contains a rich complex of polyphenolic compounds, which causes its anti-inflammatory effect. It has been revealed that in efficiency, the branches are not inferior to the bark of the species under study, which makes it possible to use branches of various willow speciesas a medicinal plant material.

Conclusion.The prospect of research of branches of various willow species, including willow triandra, as a medicinal plant raw material showing anti-inflammatory properties, is confirmed.
STUDY OF REMINERALIZING ACTIVITY OF DOSAGE FORMS FOR TREATMENT OF INITIAL ENAMEL CARIES
Authors: Golovanenko A. L. , Tretyakova E. V. , Patlusova E. S. , Alekseeva I. V. , Berezina E. S. , Pershina R. G.
Published: September 2018

One of the most promising areas of dental caries prophylaxis is remineralizing therapy aimed at normalizing the mineral composition of tooth enamel. As a result of a set of scientific, experimental and clinical studies, gels and drug films for the treatment of enamel caries have been developed.

The aimof this work is to study remineralizing activity of dosage forms for the treatment of initial enamel caries.

Materials and methods.As active pharmaceutical substances in dosage forms, calcium chloride (FS 42-0006-5675-04 P.003964.01), potassium phosphate disubstituted (FS 42-1297-79), sodium fluoride (PS.2.2.0013.15), auxiliary substances – gelling agent sodium-carboxymethylcellulose (sodium-CMC) C75 (TU 6-55-39-90), plasticizer glycerin (PS.2.2.0006.15), purified water (PS.2.2.0020.15) – have been used. Remineralizing activity was studied by the method of determination of calcium and phosphorus in the enamel ash in vitro. The study of remineralizing activity was carried out by the method of determination of calcium and phosphorus in the enamel ash in vitro. Quantitative determination of calcium was carried out by reverse complexometric titration, and the one of phosphorus was carried out by photoelectrocolorimetry. The electro-metric study of the enamel electrical conductivity was also carried out in vivo with the help of the Dentest device (Geosoft).

Results and discussion. The method of determination of calcium and phosphorus in the enamel ash in vitro is based on tooth ashing and the subsequent determination of calcium and phosphorus in it by chemical and instrumental methods. Basing on the results obtained, it has been established that gel and drug films used for enamel caries treatment significantly increase the content of calcium and phosphorus in tooth enamel. The conducted electrometric study confirmed the increase in the hardness of the enamel structure due to its remineralization after the use of drug films.

Conclusion. As a result of the studies conducted in vivo and in vitro, it has been established that the developed dosage forms have a remineralizing effect and can be recommended for increasing the effectiveness of prevention and treatment of the initial enamel caries.
Comparative Assessment of Markers of Oxidative Stress in Human-milk and Plasma of Lactating Mothers
Authors: Akiibinu Moses O. , A. Adesiyan Adekunle , O. Akiibinu Susanah
Published: September 2018

Background: Human-milk is a complex extracellular fluid with different biochemical composition compared with blood. The present study assessed the levels of markers of oxidative stress in human-milk and plasma of healthy lactating mothers.

Methods: Forty lactating mothers (22-36 years) volunteered to participate in this study. They were non-smokers and apparently normal nursing mothers who had normal delivery without postnatal complications. Blood and breast-milk samples were collected from the lactating mothers between 6th and 18th weeks after delivery. Total antioxidant potential (TAP), total plasma peroxides (TPP) and malondialdehyde (MDA) were determined in both human-milk and blood of the mothers using spectrophotometric methods. Oxidative stress index (OSI) was determined as the percent ratio of the TPP and TAP.

Results: The results showed that TAP, TPP and OSI increased significantly (p<0.001) in human-milk compared with the plasma. The plasma / human-milk ratios of TAP, TPP and OSI were 1:3, 1:5 and 1:2 respectively. The level of MDA was significantly (p=0.01) lower in the breast-milk, compared with the plasma. In the plasma, levels of OSI correlated significantly with TAP (r= -0.46; p= 0.015) and TPP (r=0.90; p <0.001) while in the breast-milk, OSI correlated significantly with only the TAP (r = -0.76; p<0.001).

Conclusion: It could be concluded that the higher TPP in the human milk would be beneficial against pathogens, while the bio-accumulated antioxidant molecules regulate free radical load to avert the consequences of oxidative stress in the breast tissue.
PECULIARITIES OF HEART RATE VARIABILITY IN NEWBORNS
Authors: Panina O. S. , Kiselev A. R. , Borovkova E. I. , Chernenkov Yu. V. , Skazkina V. V. , Gridnev V. I. , Mureeva E. N. , Karavaev A. S.
Published: September 2018

Heart rate variability values are potentially important for assessing vegetative dysfunction in children.

The purpose of the research: a comparative study of spectral heart rate variability parameters and synchronization of low-frequency oscillations, characterizing baroreflex in the vegetative regulation of the cardiovascular system in healthy newborns and adults.

15 healthy newborns and 60 healthy individuals in the age of 18-34 years old were included in the study. We performed synchronous recording of electrocardiograms and photoplethysmograms with 10 minutes duration, at rest. Were evaluated spectral heart rate variability indices and the index of synchronization of low-frequency oscillations in heart rate variability and photoplethysmograms (S index).

Results. In newborns, the peak of low-frequency oscillations was predominantly in the range 0.07–0.09 Hz, and high frequency 0.40–0.50 Hz. Newborns had lower LF% values than adults: 22.8 (14.1, 29.4) vs 32.9 (25.1, 41.9) (p=0.009). The S index in newborns was 20.1 (16.9, 26.5)%, and 33.2 (21.2, 45.4)% in healthy adults (p=0.023).

Conclusion. We have first demonstrated that the interaction of baroreflex regulation of heart rhythm and peripheral blood filling in healthy newborns is characterized by lower values of S index, than in healthy adults, which can be explained by the immaturity of the vegetative regulatory elements of the cardiovascular system.
Görme Yetersizliği Olan Öğrencilerin Dinleme Stratejilerinin Belirlenmesi
Authors: Şenel Selma , Topuzkanamış Ersoy
Published: September 2018

Görme yetersizliği olan öğrencilerin dinlediklerini anlamak için kullandıkları stratejilerin neler olduğunu ve bu
stratejileri ne düzeyde kullandıklarını ortaya koymak, bu öğrencilere yönelik tüm eğitimlerde anlamlı veriler
sağlayabilir. Bu araştırmada, görme yetersizliği olan bireylerin dinleme stratejilerini belirlemek amaçlanmıştır.
Araştırmada tarama modeli temel alınmıştır. Araştırma kapsamında görme yetersizliği olan 37 öğrenci ve görme
yetersizliği olmayan 48 öğrenci olmak üzere iki ayrı grup ile çalışılmıştır. Araştırma kapsamında beşli Likert
tipinde bir ölçek geliştirilmiştir. Araştırma sonuçlarının analizinde ilişkisiz örneklemler t-testi ve betimsel
istatistikler kullanılmıştır. Araştırma bulguları, görme yetersizliği olan bireylerin sıklıkla veya her zaman dinleme
stratejilerini kullandıklarını göstermektedir. Araştırmanın önemli bir bulgusu da, görme yetersizliği olan bireylerin
dinleme stratejilerini, görme yetersizliği olmayan bireylerden daha fazla kullanıyor olmasıdır. Öğrencilerin en sık
kullandıkları stratejilerin; dinleme amaç ve yöntemini belirleme, dikkatini toplamaya çalışma, tekrar dinleme,
dokunsal sahne oluşturma, ara özet yapma ve tartışma olduğu görülmüştür. Araştırmanın uygulamaya dönük temel
önerisi, daha az kullanılan stratejilere ilişkin eğitimler düzenlenmesidir
Gastric Duplication Cyst Associated with Esophageal Atresia and Anorectal Malformations: A Rare Association
Authors: Piplani Rajat , Bagga Deepak , Acharya Samir K
Published: September 2018

Esophageal atresia (EA) and tracheoesophageal fistula (TEF) and anorectal malformations (ARM) in a newborn usually present with frothing of saliva and massive abdominal distension rendering it difficult to diagnose associated intrabdominal pathologies. We report a large gastric duplication (GD) cyst in a 2-day-old neonate with EA and TEF. GD cyst was detected in the early post-operative period as the abdominal distension persisted after repair of EA and TEF. The baby underwent excision of GD cyst with good outcome thereafter.
Successful Development of a Fetal Ovine Model for Esophagus Tissue Engineering
Authors: Saxena Amulya K , Ainoedhofer Herwig , Soltysiak Piotr
Published: September 2018

In esophagus tissue engineering, large animal models need to be developed to generate tissues of substantive size that can be applied in the future for clinical applications. The ovine fetal model has been successfully developed in this pilot study for esophagus tissue generation. Fetus (n = 5) was operated between the 120 and 125 days of gestation (term 140 days) with a longitudinal neck incision through which the esophagus was exposed. Full-thickness esophagus biopsies were obtained after which an end-to-end anastomosis was performed. Organoid units isolated from biopsies were seeded on collagen scaffolds to create tubular constructs which were implanted into the fetal omentum. The fetuses were returned and the pregnancy continued. There was no mortality and all five lambs were delivered at term. “Rudimentary” tissue engineered esophagus was generated using the omentum as an in situ bioreactor. The ovine fetal model for esophagus tissue engineering could successfully be established in this pilot study.
Congenital Megalourethra
Authors: Sarin Yogesh Kumar , Jain Nitin , Kumar Parveen
Published: September 2018

Congenital megalourethra is a rare mesenchymal anomaly of the male urethra. A sparse literature is available for its early surgical management. We present here an antenatally diagnosed case of congenital megalourethra, who underwent reduction urethroplasty at 18 days of life. To the best of our knowledge, this is the youngest case reported hitherto.
Duodenal Duplication Cyst in Close Proximity of Ampulla of Vater: A Surgical Challenge
Authors: Kechiche Nahla , Farhani Rabeb , Lamiri Rachida , Nouri Abdelatif
Published: September 2018

Prompt preoperative diagnosis of duodenal duplication cyst is uncommon owing to its extreme rarity. The ideal treatment of intestinal duplication cyst is complete surgical excision, though in few cases, due to the proximity to the bilio-pancreatic duct, the complete excision is not possible. We herein present an infant presenting with bilious vomiting starting few days after birth. Ultrasonography and CT scan provided the diagnosis of the duplication cyst in relation to duodenum. A successful surgical management by a subtotal excision was done. Although duodenal duplication is seldom seen, it should be considered in differential diagnoses of upper gastrointestinal tract (GIT) occlusion.
Efficacy of a Mobile Social Networking Intervention in Promoting Physical Activity: Quasi-Experimental Study (Preprint)
Authors: Tong Huong Ly , Coiera Enrico , Tong William , Wang Ying , Quiroz Juan C , Martin Paige , Laranjo Liliana
Published: September 2018

BACKGROUND

Technological interventions such as mobile apps, Web-based social networks, and wearable trackers have the potential to influence physical activity; yet, only a few studies have examined the efficacy of an intervention bundle combining these different technologies.

OBJECTIVE

This study aimed to pilot test an intervention composed of a social networking mobile app, connected with a wearable tracker, and investigate its efficacy in improving physical activity, as well as explore participant engagement and the usability of the app.

METHODS

This was a pre-post quasi-experimental study with 1 arm, where participants were subjected to the intervention for a 6-month period. The primary outcome measure was the difference in daily step count between baseline and 6 months. Secondary outcome measures included engagement with the intervention and system usability. Descriptive and inferential statistical tests were conducted; posthoc subgroup analyses were carried out for participants with different levels of steps at baseline, app usage, and social features usage.

RESULTS

A total of 55 participants were enrolled in the study; the mean age was 23.6 years and 28 (51%) were female. There was a nonstatistically significant increase in the average daily step count between baseline and 6 months (mean change=14.5 steps/day, P=.98, 95% CI –1136.5 to 1107.5). Subgroup analysis comparing the higher and lower physical activity groups at baseline showed that the latter had a statistically significantly higher increase in their daily step count (group difference in mean change from baseline to 6 months=3025 steps per day, P=.008, 95% CI 837.9-5211.8). At 6 months, the retention rate was 82% (45/55); app usage decreased over time. The mean system usability score was 60.1 (SD 19.2).

CONCLUSIONS

This study showed the preliminary efficacy of a mobile social networking intervention, integrated with a wearable tracker to promote physical activity, particularly for less physically active subgroups of the population. Future research should explore how to address challenges faced by physically inactive people to provide tailored advices. In addition, users’ perspectives should be explored to shed light on factors that might influence their engagement with the intervention.
The application of virtual reality in health professions� digital education: a narrative review (Preprint)
Authors: Tudor Car Lorraine , Kyaw Bhone Myint , Car Josip
Published: September 2018

BACKGROUND

Digital technology called Virtual Reality (VR) is increasingly employed in health professions’ education. Yet, based on the current evidence, its use is narrowed around a few most applications and disciplines. There is a lack of an overview that would capture the diversity of different VR applications in health professions’ education and inform its use and research.

OBJECTIVE

This narrative review aims to explore different potential applications of VR in health professions’ education.

METHODS

The narrative synthesis approach to literature review was used to analyse the existing evidence.

RESULTS

We outline the role of VR features such as immersion, interactivity and feedback and explain the role of VR devices. Based on the type and scope of educational content VR can represent space, individuals, objects, structures or their combination. Application of VR in medical education encompasses environmental, organ and micro level. Environmental VR focuses on training in relation to health professionals’ environment and human interactions. Organ VR educational content targets primarily human body anatomy; and micro VR microscopic structures at the level of cells, molecules and atoms. We examine how different VR features and health professional education areas match these three VR types.

CONCLUSIONS

We conclude by highlighting the gaps in the literature and providing suggestions for future research.