bluuebunny/crossref_metadata_2025 huggingface dataset:
An image processing approach to identify solar plages observed at 393.37 nm by the Kodaikanal solar observatory
Authors: Gharat Sarvesh , Bose Bhaskar , Borthakur Abhimanyu , Mazumder Rakesh
Published: July 2023

Solar plages, which are bright regions on the Sun’s surface, are an important indicator of solar activity. In this study, we propose an automated algorithm for identifying solar plages in Ca-K wavelength solar data obtained from the Kodaikanal Solar Observatory. The algorithm successfully annotates all visually identifiable plages in an image and outputs the corresponding calculated plage index. We perform a time series analysis of the plage index (rolling mean) across multiple solar cycles to test the algorithm’s reliability and robustness. The results show a strong correlation between the calculated plage index and those reported in a previous study. The correlation coefficients obtained for all the solar cycles are higher than 0.90, indicating the reliability of the model. We also suggest that adjusting the hyperparameters appropriately for a specific image using our web-based app can increase the model’s efficiency. The algorithm has been deployed on the Streamlit Community Cloud platform, where users can upload images and customize the hyperparameters for desired results. The input data used in this study is freely available from the KSO data archive, and the code and the generated data are publicly available on our GitHub repository. Our proposed algorithm provides an efficient and reliable method for identifying solar plages, which can aid the study of solar activity and its impact on the Earth’s climate, technology, and space weather.
The comparative performance of three screening questionnaires for psoriatic arthritis in a primary care surveillance study
Authors: Helliwell Philip S , Coates Laura C , Ransom Myka , Brown Sarah T , Packham Jonathan , Weddell Jake , Tillett William , McHugh Neil ,   the PROMPT Study Group, Bjoke Laura , Dures Emma , James Jana , Madhok Vishnu , Smith Catherine , Spackman Eldon , Parkinson Andrew , Tassinari Cerys , Turfrey Mel (Brooke)
Published: July 2023

Objectives

The objective of this study was to compare the performance of three PsA screening questionnaires in a primary care psoriasis surveillance study.

Methods

Participants with psoriasis, and not known to have PsA, were identified from general practice databases and invited to attend a secondary care centre for a clinical assessment. The three patient-completed screening questionnaires (PEST, CONTEST and CONTESTjt) were administered, along with other patient-reported measures, and a clinical examination of skin and joints was performed. Participants who demonstrated signs of inflammatory arthritis suggestive of PsA were referred, via their GP, for a further assessment in a secondary care rheumatology clinic.

Results

A total of 791 participants attended the screening visit, and 165 participants were judged to have signs and symptoms of inflammatory arthritis, of which 150 were referred for assessment. Of these, 126 were seen and 48 were diagnosed with PsA. The results for each questionnaire were as follows: PEST: sensitivity 0.625 (95% CI 0.482, 0.749), specificity 0.757 (0.724, 0.787); CONTEST: sensitivity 0.604 (0.461, 0.731), specificity 0.768 (0.736, 0.798); and CONTESTjt: sensitivity 0.542 (0.401, 0.676), specificity 0.834 (0.805, 0.859). CONTESTjt demonstrated marginally superior specificity to PEST, though the area under the ROC curve was similar for all three instruments.

Conclusion

Minimal differences between the three screening questionnaires were found in this study, and no preferred questionnaire is indicated by these results. The choice of which instrument to choose will depend on other factors, such as simplicity and low patient burden.
Learning, Hope, and Empowerment
Authors: Lee Soeun , Jordan Abbie , Walker Nicole , Nauman Hiba , Dick Bruce , McMurtry C. Meghan
Published: July 2023

Objectives:

Limited research has investigated parent-targeted interventions in pediatric chronic pain, though these interventions may be an important part of family-centered care. Further, parent perspectives and feedback regarding these interventions are scant in the literature, even though they are crucial for developing, refining, and optimizing treatment options. This study aimed to understand how parents experience and perceive their participation in a Cognitive Behavioral Therapy (CBT) based, parent-targeted group intervention that was delivered either in-person or virtually, with a focus on the treatment components they found most important.

Methods:

Data from semi-structured focus groups/interviews within one week post-treatment with 32 parents (n=11 in-person, n=21 virtual) were analyzed using an inductive reflexive thematic analysis.

Results:

Three overarching themes were generated from the thematic analysis: building a foundation of knowledge, finding normalization and hope through connection and lived experiences, and sharing a collective responsibility for pain management.

Discussion:

Parents perceived a range of benefits from participating in a CBT-based, parent-targeted group intervention, both on themselves and for their youth. Overall, parent perceptions across in-person and virtual intervention delivery were consistent, except for a drawback of virtual participation for developing a deeper social connection among parents. Thus, a relatively brief parent-targeted group intervention was perceived to be a positive experience for parents, though considerations for adapting to virtual delivery and facilitating social connection among parents appears to be important.
Time Effect on Acute Postoperative Pain After Total Knee Replacement Surgery: An Exploratory Study Using the Experience Sampling Method
Authors: Balthasar Andrea JR , Willemen Jasmijn , Vossen Carine , Boymans Tim , Lousberg Richel
Published: July 2023

Objectives:

Acute postoperative pain (APP) is the main cause of postoperative dissatisfaction; however, traditional methods of pain assessment provide limited insights into the dynamics and development of APP. This study used the experience sampling method (ESM) to understand the dynamics of APP over time in relation to various patient factors.

Methods:

Forty patients scheduled to undergo total knee replacement surgery were recruited in this study. Following an initial assessment, a short report questionnaire was sent to the patients via 10 digital alerts per day to assess the pain levels during two preoperative and the first 6 postoperative days. The data were analyzed using multilevel regression including random intercept and slope.

Results:

Thirty-two patients submitted the pre-specified minimum of 30% of their short reports, yielding 1217 records. The analysis revealed significant (P<0.001) linear and quadratic decreases in APP and a quadratic time effect. The lowest between-days and within-day pain levels were observed on postoperative day 4.8 and during the time slot 3.8 or approximately 19:15, respectively. Significant random intercepts and slopes were noted, indicating variations in the mean pain level between patients and a decrease in pain. None of the 10 patient factors had any confounding effect.

Discussion:

Using ESM data combined with multilevel analysis, we were able to evaluate the postoperative pain course while considering inter-individual differences in the baseline pain level and non-linear pain course over time. The findings of this study could aid clinicians in personalizing the treatment for APP.
A Medial Approach That Provides Ample Exposure of the Coronoid for Fracture Management
Authors: Orbay Jorge L. , Heifner John J. , Gray Robert R.L. , Rubio Francisco , Hoekzema Nathan A. , Mercer Deana M.
Published: July 2023

We describe a medial approach to the coronoid where the flexor-pronator mass is released from its humeral origin by creating a proximally based tendinous flap. This technique facilitates access to the coronoid, preservation of the medial collateral ligament origin, and repair of the flexor-pronator mass. This approach has utility for all coronoid fracture variations but especially the O’Driscoll anteromedial subtype 3, which includes fractures of the sublime tubercle, the anteromedial facet, and the coronoid tip.
Population genomics reveals mechanisms and dynamics of de novo expressed open reading frame emergence inDrosophila melanogaster
Authors: Grandchamp Anna , Kühl Lucas , Lebherz Marie , Brüggemann Kathrin , Parsch John , Bornberg-Bauer Erich
Published: July 2023

Novel genes are essential for evolutionary innovations and differ substantially even between closely related species. Recently, multiple studies across many taxa showed that some novel genes arise de novo, that is, from previously noncoding DNA. To characterize the underlying mutations that allowed de novo gene emergence and their order of occurrence, homologous regions must be detected within noncoding sequences in closely related sister genomes. So far, most studies do not detect noncoding homologs of de novo genes because of incomplete assemblies and annotations, and long evolutionary distances separating genomes. Here, we overcome these issues by searching for de novo expressed open reading frames (neORFs), the not-yet fixed precursors of de novo genes that emerged within a single species. We sequenced and assembled genomes with long-read technology and the corresponding transcriptomes from inbred lines ofDrosophila melanogaster, derived from seven geographically diverse populations. We found line-specific neORFs in abundance but few neORFs shared by lines, suggesting a rapid turnover. Gain and loss of transcription is more frequent than the creation of ORFs, for example, by forming new start and stop codons. Consequently, the gain of ORFs becomes rate limiting and is frequently the initial step in neORFs emergence. Furthermore, transposable elements (TEs) are major drivers for intragenomic duplications of neORFs, yet TE insertions are less important for the emergence of neORFs. However, highly mutable genomic regions around TEs provide new features that enable gene birth. In conclusion, neORFs have a high birth-death rate, are rapidly purged, but surviving neORFs spread neutrally through populations and within genomes.
Beyond evidence and reality: the politics, political economy and fallout of hawkish regulatory policy on prescription drugs in Nigeria
Authors: Otu Smart E. , Nnam Macpherson Uchenna , Eteng Mary Juachi , Amugo Ijeoma Mercy , Idowu Babatunde Michel
Published: July 2023

Purpose

The purpose of this study is to examine the politics, political economy, and fallout of hawkish regulatory policy on prescription drugs in Nigeria. Hawkish regulatory policy on prescription drug in Nigeria, such as opioid analgesics, is a very complex and multifaceted one, which usually involves the interplay of many factors and parties.

Design/methodology/approach

Policy manuals, official government gazettes (legislations, regulations, Acts and decrees), academic literature and a direct ethnographic observation of events surrounding the regulation of prescription drugs were reviewed and engaged.

Findings

The results revealed that Nigerian and global political economy and politics interface to define the direction of the new restrictive opioid policy, with resultant friction between prohibition and consumption. The reviews showed that the overarching “get-tough” and “repressive” policy are not necessarily founded on empirical evidence of an increase in prescription drug sales or use, but more as a product of the interplay of both internal and external politics and the prevailing socioeconomic order.

Practical implications

Instead of borrowing extensively from or being influenced by repressive Western drug laws and perspectives, Nigerian policymakers on prescription opioids should take control of the process by drawing up a home-grown policy that is less intrusive and punitive in nature for better outcomes. A mental sea change is required to understand the intrigues of Western power in Nigeria’s politics and political economy to avoid the continuous symptomatic failure of drug policy.

Originality/value

The politics and economic influence of the United Nations, USA and Western powers, as well as the axiom of moral panic of prescription drugs scares within the Nigerian environment, are particularly significant in the making of the emerging hawkish policy on prescription drugs in Nigeria.
Trend over time of HIV‐1 drug resistance to nonnucleoside reverse transcriptase inhibitors (NNRTIs) and their drivers: A cohort study from Antiviral Response Cohort Analysis (ARCA)
Authors: Rancan Ilaria , Cassol Chiara , Graziani Lucia , Tilli Marta , Malcontenti Costanza , Russo Chiara , Bottanelli Martina , Bracchitta Fiorenza , Papaioannu Rebecka , Labate Laura , Mora Sara , Bezenchek Antonia , Shallvari Adrian , Di Biagio Antonio , Rossetti Barbara
Published: July 2023

The rise of HIV‐1 drug resistance to nonnucleoside reverse transcriptase inhibitors (NNRTIs) threatens the long‐term success of NNRTI‐based therapies. Our study aims to describe the circulation of major resistance‐associated mutations (RAMs) for NNRTIs in people living with HIV (PLWH) in Italy from 2000 to 2020. We included 5982 naïves and 28 505 genotypes from 9387 treatment‐experienced PLWH from the Antiviral Response Cohort Analysis (ARCA) cohort. Transmitted drug resistance (TDR) was found in 12.5% and declined from 17.3% in 2000–2003 to 10.9% in 2016–2020 (p = 0.003). Predictors of TDR were viral subtype B [vs. non‐B, adjusted odds ratio (aOR) = 1.94, p < 0.001], zenith viral load (VL) (per 1 log10 higher, aOR = 0.86, p = 0.013), nadir CD4 cell count (per 100 cells/μL increase aOR = 0.95, p = 0.013). At least one RAM for NNRTIs among treatment experienced PLWH was detected in 33.2% and pre‐treatment drug resistance (PDR) declined from 43.4% in 2000–2003 to 20.9% in 2016–2020 (p < 0.001). Predictors of PDR were sexual transmission route (vs. others, aOR = 0.78, p < 0.001), time since HIV diagnosis (per 1 month longer, aOR = 1.002, p < 0.001), viral subtype B (vs. non B, aOR = 1.37, p < 0.001), VL (per 1 log10 higher, aOR = 1.12, p < 0.001), nadir CD4 count (per 100 cells/μL increase, aOR = 0.91, p < 0.001), previous exposure to any NNRTI (aOR = 2.31, p < 0.001) and a more recent calendar year sequence (any time span > 2008 vs. 2000–2003, any aOR <1, p < 0.001). Circulation of RAMs to NNRTIs declined during the last 20 years in Italy. NNRTIs remain pivotal drugs for the management of HIV‐1 due to safety concerns and long‐acting options.
AMPK/mTOR pathway significance in healthy liver and non‐alcoholic fatty liver disease and its progression
Authors: Marcondes‐de‐Castro Ilitch Aquino , Reis‐Barbosa Pedro Henrique , Marinho Thatiany Souza , Aguila Marcia Barbosa , Mandarim‐de‐Lacerda Carlos Alberto
Published: July 2023

Obesity is related to several organs, but the liver is particularly affected. Adenosine monophosphate‐activated protein kinase (AMPK) is a cellular energy sensor and regulator of liver lipid dysfunction and glucose metabolism. The mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival, metabolism, and immunity. Together, these pathways are involved in obesity, insulin resistance, non‐alcoholic fatty liver disease (NAFLD) and its progression, and autophagy. During energy demand, liver kinase B (LKB) phosphorylation helps activate the AMPK/mTOR pathways. Likewise, the protein forkhead box O family (FOXO) negatively regulates adipogenesis by binding to the promoter sites of peroxisome proliferator‐activated receptor‐gamma coactivator 1‐alpha, initiating adipogenesis. In addition, acetyl‐CoA carboxylase, which regulates de novo lipogenesis, is linked to LKB and FOXO in developing NAFLD. The kinase complex, consisting of Unc‐51‐like autophagy‐activating kinase 1 or 2 (ULK1, ULK2) by stimulating autophagy, and eliminating fat droplets in NAFLD, is regulated by mTORC1 and negatively regulated by AMPK that suppresses liver lipogenesis and increases fatty acid oxidation. Also, ULK1 is essential for initiating phagophore formation, establishing macrophagy, and generating autophagosomes. The selective breakdown of lipid droplets through macroautophagy, or macrolipophagy, occurs on a cellular energy level using free fatty acids. In addition, mTORC1 promotes lipogenesis by activating sterol regulatory element‐binding protein. Finding new components and novel regulatory modes in signaling is significant for a better understanding of the AMPK/mTOR pathways, potentially facilitating the development of future diagnostic and therapeutic strategies for NAFLD and its progression to non‐alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma.
Climate risk and renewable energy technological innovation: An institutional environment perspective
Authors: Chen Jinyu , Luo Xianfeng , Ding Qian
Published: July 2023

To explore whether climate risk (CR) affects renewable energy technological innovation (RETI) and its boundary conditions, this study examines the relationship between CR and RETI as moderated by institutional environment. Based on panel data of 60 countries for the period 2000–2019, we show that CR is not conducive to RETI, and that its negative marginal impact shows an inverted U‐shaped trend with the improvement of RETI. Heterogeneity analysis shows that floods and storms have the greatest negative impacts on RETI, and that innovations in solar and wind energy technologies are more vulnerable to the adverse shocks of CR. Furthermore, CR has a greater adverse effect on RETI in developing countries than in developed countries. However, the institutional environment, especially the economic institutional environment, can work to mitigate the negative effect of CR on RETI. Our findings not only enrich the research on the economic consequences of CR but also provide effective ways to mitigate the adverse impact of CR on RETI from the perspective of institutional environment.
Prevalence of neoplasia and concurrent diseases in dogs and cats with hypercobalaminemia: A retrospective case–control study
Authors: Henry Perrine M. N. , Williams Tim L.
Published: July 2023

Background

Hypercobalaminemia is infrequently reported in companion animals and is considered of low clinical significance. Recent studies have described its association with inflammatory, immune‐mediated, endocrine, and neoplastic conditions in dogs and cats.

Objectives

We aimed to investigate the association between hypercobalaminemia and neoplasia in companion animals and to identify other concurrent diseases or clinicopathologic changes.

Methods

This is a retrospective, case–control study. Medical records of patients with measured serum cobalamin concentration (2015‐2020) and no history of prior supplementation were reviewed. Hypocobalaminemic animals were excluded. Variables were compared between groups (hypercobalaminemic vs. normocobalaminemic) using non‐parametric statistics. Data are presented as median (range).

Results

Thirty‐five dogs and eight cats were hypercobalaminemic. At baseline, neoplasia was confirmed in 4/35 hypercobalaminemic dogs versus 11/70 control dogs (P = 0.77) and 0/8 hypercobalaminemic cats versus 3/16 control cats (P = 0.53). Cases without neoplasia at baseline were followed for 409 (13‐1854) days (dogs, n = 78) and 395 (28‐1670) days (cats, n = 21). During follow‐up, neoplasia was diagnosed in 4/27 hypercobalaminemic dogs versus 3/51 control dogs (P = 0.23) and 1/8 hypercobalaminemic cats versus 0/13 control cats (P = 0.38).

Pancreatitis was more frequent in hypercobalaminemic dogs (P = 0.006). Hypercobalaminemic dogs had higher serum total protein (P = 0.014), globulin (P = 0.001), and CRP (P = 0.032) concentrations and lower serum sodium (P = 0.012) and chloride (P = 0.033) concentrations than controls. Hypercobalaminemic cats had higher serum total protein concentrations than controls (P = 0.008).

Conclusion

Our results suggest that hypercobalaminemia is not associated with the presence or development of neoplasia in dogs and cats but may be associated with systemic inflammatory conditions, including pancreatitis, in dogs.
Tensiones decoloniales y complejidad del conocimiento sociocultural de la subalternidad
Authors: Ocampo González Aldo
Published: July 2023

Este trabajo analiza la naturaleza inconmensurable e inconmensurada de la subalternidad, lo que materializa una posición sin una identidad cuya inteligibilidad es compleja, especialmente, cuando intentamos acceder a las configuraciones de su esquema ontopolítico. La subalternidad construye una oposición binaria al Estado-nación. Es necesario luchar por la producción de nuevos criterios de legibilidad del sujeto educativo y cultural. Tal problema se reduce a una obstrucción en sus reglas de inteligibilidad ontopolíticas y existenciales de una amplia constelación de grupos específicos heterogéneos, amalgamados a través de problemáticas políticas, estructurales, relacionales, contingentes e históricas que determinan sus unidades de legibilidad cultural. El método empleado es revisión documental crítica, organizando un corpus crítico de trabajos sobre estudios interculturales, subalternidad y la poscolonialidad. Cada uno de ellos son claves para promover otro tipo de desempeños epistemológicos al respecto. Entre los principales resultados y conclusiones, se observa que, la subalternidad documenta un problema metodológico más profundo: no sabemos con exactitud en qué consiste la agencia cultural y política de tales grupos. Lo único que no debemos olvidar es que, nosotros, los educadores, estamos al servicio de grupos subalternos, nuestra tarea es aprender de su entorno, convertirnos en un discípulo de su espacio cultural.
Multichip multidimensional quantum networks with entanglement retrievability
Authors: Zheng Yun , Zhai Chonghao , Liu Dajian , Mao Jun , Chen Xiaojiong , Dai Tianxiang , Huang Jieshan , Bao Jueming , Fu Zhaorong , Tong Yeyu , Zhou Xuetong , Yang Yan , Tang Bo , Li Zhihua , Li Yan , Gong Qihuang , Tsang Hon Ki , Dai Daoxin , Wang Jianwei
Published: July 2023

Quantum networks provide the framework for quantum communication, clock synchronization, distributed quantum computing, and sensing. Implementing large-scale and practical quantum networks relies on the development of scalable architecture and integrated hardware that can coherently interconnect many remote quantum nodes by sharing multidimensional entanglement through complex-medium quantum channels. We demonstrate a multichip multidimensional quantum entanglement network based on mass-manufacturable integrated-nanophotonic quantum node chips fabricated on a silicon wafer by means of complementary metal-oxide-semiconductor processes. Using hybrid multiplexing, we show that multiple multidimensional entangled states can be distributed across multiple chips connected by few-mode fibers. We developed a technique that can efficiently retrieve multidimensional entanglement in complex-medium quantum channels, which is important for practical uses. Our work demonstrates the enabling capabilities of realizing large-scale practical chip-based quantum entanglement networks.
Testing for Human Papillomaviruses in Urine, Blood, and Oral Specimens: an Update for the Laboratory
Authors: Poljak Mario , Cuschieri Kate , Alemany Laia , Vorsters Alex
Published: July 2023

Twelve high-risk alpha human papillomavirus (HPV) genotypes cause approximately 690,000 cancer cases annually, with cervical and oropharyngeal cancer being the two most prominent types. HPV testing is performed in laboratory settings for various applications of a clinical, epidemiological, and research nature using a range of clinical specimens collected by clinicians or by individuals (self-collected specimens).
Growth and survival of native upland and wetland species in shallow capped thickened tailings: a meso-scale greenhouse study
Authors: Degenhardt Dani , Van Dongen Angeline , Schreiber Stefan G. , Bekele Asfaw
Published: July 2023

This 3 year meso-scale greenhouse study used 55 gallon columns to evaluate the survival and growth of boreal upland and wetland communities on thickened tailings (TT) with 0 cm, 10 cm, and 30 cm peat mineral mix (PMM) reclamation cap. While survival was high in all treatments, the PMM cap treatments showed significant improvement in overall plant growth, cover, and above-ground biomass compared to the uncapped treatment, with growth on the 30 cm PMM cap outperforming the 10 cm PMM cap. The plant growth response was similar between the two communities and the top performing species, in terms of survival and growth, in capped TT were Cornus sericea, Populus tremuloides, Salix bebbiana, and Scirpus microcarpus.
Taiwan’s Southbound Drive towards Southeast Asia
Authors: JING Bo-jiun
Published: July 2023

This article examines Taiwan’s foreign policy towards Southeast Asia during Ma Ying-jeou’s two-term (2008–2016) and Tsai Ing-wen’s first-term (2016–2020) presidencies. It discusses the context of East Asian regionalisation and regionalism, and Ma’s and Tsai’s primary objectives for their strategies in relation to the ASEAN region. With a focus on their trade, investment, tourism and higher education policies towards the region, this article evaluates how successful their polices have been in achieving the goals in the relevant areas.
Taiwan’s November 2022 Mid-term Election
Authors: COPPER John F
Published: July 2023

In late 2022, Taiwan held its every four years mid-term election that was comprised of almost all of its local electoral contests; the ruling Democratic Progressive Party lost. President Tsai Ing-wen was blamed for the defeat for having focused excessively on tension with China while ignoring local problems. She was also seen to depend too much on the Biden administration’s China’s policy. After the election, observers predicted the election would give the opposition Nationalist Party (or Kuomintang, KMT) momentum to win the national presidential, vice-presidential and legislative election in January 2024. Subsequent events and polls, however, indicated a close contest.
Sino–American Relations in the Trump Era
Authors: FATTAH Ali
Published: July 2023

For years, China and the United States have clashed on various issues, including trade, technology and the South China Sea. Strategic competition between the two superpowers had intensified under the Donald Trump administration, leading to worsening Sino–American bilateral relations. These tensions created resentment on both sides that influenced the respective country’s policies across a range of issues and led to a new phase of the conflict that some strategists had already characterised as a new Cold War.
Finite Impulse Response Filter Design Using Fuzzy Logic-Based Diversity-Controlled Self-Adaptive Differential Evolution
Authors: Mohaideen Abdul Kadhar K. , Rengarajan S. , Tamilselvi S. , Karuppiah N. , Balachandran Praveen Kumar , Thamilmaran A. , Dhanamjayulu C. , Khan Baseem
Published: July 2023

The design of finite impulse response (FIR) filters involves the estimation of effective filter coefficients, making the designed filter exhibit infinite stopband attenuation and have a flat-shaped passband. The few conventional filter design methods such as impulse response truncation (IRT) and windowing technique exhibit undesirable characteristics owing to the Gibbs phenomenon, thus making them unsuitable for various practical complexities. This research work employs the fuzzy logic-based diversity-controlled self-adaptive differential evolution algorithm (FLDCSaDE) for the design of FIR band stop (BS) and high pass (HP) filters. In order to validate the results of the proposed technique, various population-based evolutionary computing techniques such as the covariance matrix adaptation evolution strategy (CMAES), differential evolution (DE), self-adaptive differential evolution (SaDE), and Jaya algorithm have also been applied for determining the effective filter coefficients. The performance of the various algorithms has been analysed and compared based on the parameters such as stopband attenuation, passband attenuation, and ripples. The simulation results show that the FLDCSaDE algorithm outperforms other evolutionary algorithms having 4% and 1.5% lower ripples than the SaDE algorithm for high pass and band stop filters, respectively. Experimental results depict that the performance of the fuzzy approach causes positioning and tracking accuracy obtained to be improved by 27% and the corresponding false positive rate (FPR) is substantially reduced to 0.11 from the mean amplitude value obtained from the fuzzy approach in the frequency response. The frequency response obtained from the FLDCSaDE algorithm is close to the ideal response of the BS and HP FIR filters.
Probabilistic Evaluation of Seismic Performance of Steel Buildings with Torsional Irregularities in Plan and Soft Story under Mainshock-Aftershock Sequence
Authors: Kouhestanian Hamed , Razmkhah Mohammad Hossein , Shafaei Jalil , Pahlavan Hossein , Shamekhi Amiri Mohammad
Published: July 2023

Due to the tectonic plate movement, numerous aftershocks may occur following an earthquake. There are several real mainshock-aftershock ground motion records in which the peak ground acceleration of aftershock is greater than that of the mainshock. Furthermore, irregularities such as soft story and torsional irregularity may change the structural behavior under the influence of earthquakes. This study investigates the fragility curves associated with the three-, five-, and eight-story models with steel moment-resisting frames under the main earthquake and mainshock-aftershock sequence to probabilistically evaluate the aftershock impacts on the steel structures with irregularities in the plan and height. The seismic fragility curves were calculated for four damage levels by selecting the relative displacement capacity at seismic performance levels of slight, moderate, extensive, and complete damage from the US HAZUS code. The analysis was done using structural reliability relationships and incremental dynamic analysis with the OpenSees software platform. The analytical results showed that the structures with soft-story and torsional irregularity were more vulnerable with an increasing number of stories. Also, aftershocks were found to have a more destructive effect on low-rise models. The probability of structural collapse in a given peak ground acceleration for a damaged state due to the mainshock-aftershock sequence is higher than that of the mainshock sequence.
Supplementary Table S3 from Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer
Authors: Williams Christopher J.M. , Elliott Faye , Sapanara Nancy , Aghaei Faranak , Zhang Liping , Muranyi Andrea , Yan Dongyao , Bai Isaac , Zhao Zuo , Shires Michael , Wood Henry M. , Richman Susan D. , Hemmings Gemma , Hale Michael , Bottomley Daniel , Galvin Leanne , Cartlidge Caroline , Dance Sarah , Bacon Chris M. , Mansfield Laura , Young-Zvandasara Kathe , Sudan Ajay , Lambert Katy , Bibby Irena , Coupland Sarah E. , Montazeri Amir , Kipling Natalie , Hughes Kathryn , Cross Simon S. , Dewdney Alice , Pheasey Leanne , Leng Cathryn , Gochera Tatenda , Mangham D. Chas , Saunders Mark , Pritchard Martin , Stott Helen , Mukherjee Abhik , Ilyas Mohammad , Silverman Rafael , Hyland Georgina , Sculthorpe Declan , Thornton Kirsty , Gould Imogen , O'Callaghan Ann , Brown Nicholas , Turnbull Samantha , Shaw Lisa , Seymour Matthew T. , West Nicholas P. , Seligmann Jenny F. , Singh Shalini , Shanmugam Kandavel , Quirke Philip
Published: July 2023

Representativeness of study participants
Supplementary Methods S1 from Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer
Authors: Williams Christopher J.M. , Elliott Faye , Sapanara Nancy , Aghaei Faranak , Zhang Liping , Muranyi Andrea , Yan Dongyao , Bai Isaac , Zhao Zuo , Shires Michael , Wood Henry M. , Richman Susan D. , Hemmings Gemma , Hale Michael , Bottomley Daniel , Galvin Leanne , Cartlidge Caroline , Dance Sarah , Bacon Chris M. , Mansfield Laura , Young-Zvandasara Kathe , Sudan Ajay , Lambert Katy , Bibby Irena , Coupland Sarah E. , Montazeri Amir , Kipling Natalie , Hughes Kathryn , Cross Simon S. , Dewdney Alice , Pheasey Leanne , Leng Cathryn , Gochera Tatenda , Mangham D. Chas , Saunders Mark , Pritchard Martin , Stott Helen , Mukherjee Abhik , Ilyas Mohammad , Silverman Rafael , Hyland Georgina , Sculthorpe Declan , Thornton Kirsty , Gould Imogen , O'Callaghan Ann , Brown Nicholas , Turnbull Samantha , Shaw Lisa , Seymour Matthew T. , West Nicholas P. , Seligmann Jenny F. , Singh Shalini , Shanmugam Kandavel , Quirke Philip
Published: July 2023

Supplementary methods
Supplementary table S2 from B-cell Receptor Pathway Mutations Are Infrequent in Patients with Chronic Lymphocytic Leukemia on Continuous Ibrutinib Therapy
Authors: Woyach Jennifer A. , Ghia Paolo , Byrd John C. , Ahn Inhye E. , Moreno Carol , O'Brien Susan M. , Jones Daniel , Cheung Leo W.K. , Chong Elizabeth , Kwei Kevin , Dean James P. , James Danelle F. , Wiestner Adrian
Published: July 2023

Supplemental Table 2. Detailed information on samples with detected BTK mutations
Supplementary Methods S1 from B-cell Receptor Pathway Mutations Are Infrequent in Patients with Chronic Lymphocytic Leukemia on Continuous Ibrutinib Therapy
Authors: Woyach Jennifer A. , Ghia Paolo , Byrd John C. , Ahn Inhye E. , Moreno Carol , O'Brien Susan M. , Jones Daniel , Cheung Leo W.K. , Chong Elizabeth , Kwei Kevin , Dean James P. , James Danelle F. , Wiestner Adrian
Published: July 2023

Supplemental methods discussing mutation testing.
BCR/Integrin Interaction in CLL: A Physiologic Remnant with Clinical Relevance
Authors: Tissino Erika , Bomben Riccardo , Gattei Valter , Zucchetto Antonella
Published: July 2023

CD49d, the alpha chain of the very late antigen-4 (VLA-4) integrin, has a negative prognostic impact in chronic lymphocytic leukemia treated with the Bruton's tyrosine kinase (BTK) inhibitors, ibrutinib and acalabrutinib. Despite BTK inhibition, VLA-4 remains inside-out activated via B-cell receptor, an activation dampened by phosphoinositide 3-kinase inhibitors. Evaluation of CD49d expression in patients starting BTK inhibitor therapy may improve their prognostic stratification.

See related article by Alsadhan et al., p. 3612
Supplementary Table S8 from Clinical Activity and Exploratory Resistance Mechanism of Milademetan, an MDM2 Inhibitor, in Intimal Sarcoma with MDM2 Amplification: An Open-Label Phase Ib/II Study
Authors: Koyama Takafumi , Shimizu Toshio , Kojima Yuki , Sudo Kazuki , Okuma Hitomi Sumiyoshi , Shimoi Tatsunori , Ichikawa Hitoshi , Kohsaka Shinji , Sadachi Ryo , Hirakawa Akihiro , Yoshida Akihiko , Ando Reiko Makihara , Ueno Toshihide , Yanagaki Mitsuru , Matsui Naoko , Nakamura Kenichi , Yamamoto Noboru , Yonemori Kan
Published: July 2023

Eligibility and exclusion criteria
Supplementary Table S6 from Clinical Activity and Exploratory Resistance Mechanism of Milademetan, an MDM2 Inhibitor, in Intimal Sarcoma with MDM2 Amplification: An Open-Label Phase Ib/II Study
Authors: Koyama Takafumi , Shimizu Toshio , Kojima Yuki , Sudo Kazuki , Okuma Hitomi Sumiyoshi , Shimoi Tatsunori , Ichikawa Hitoshi , Kohsaka Shinji , Sadachi Ryo , Hirakawa Akihiro , Yoshida Akihiko , Ando Reiko Makihara , Ueno Toshihide , Yanagaki Mitsuru , Matsui Naoko , Nakamura Kenichi , Yamamoto Noboru , Yonemori Kan
Published: July 2023

Targeted sequencing analysis of cell-free DNA samples
Supplementary Figure S5 from Clinical Activity and Exploratory Resistance Mechanism of Milademetan, an MDM2 Inhibitor, in Intimal Sarcoma with MDM2 Amplification: An Open-Label Phase Ib/II Study
Authors: Koyama Takafumi , Shimizu Toshio , Kojima Yuki , Sudo Kazuki , Okuma Hitomi Sumiyoshi , Shimoi Tatsunori , Ichikawa Hitoshi , Kohsaka Shinji , Sadachi Ryo , Hirakawa Akihiro , Yoshida Akihiko , Ando Reiko Makihara , Ueno Toshihide , Yanagaki Mitsuru , Matsui Naoko , Nakamura Kenichi , Yamamoto Noboru , Yonemori Kan
Published: July 2023

Correlation between the MDM2 copy number and tumor shrinkage
Supplementary Figure S4B from Clinical Activity and Exploratory Resistance Mechanism of Milademetan, an MDM2 Inhibitor, in Intimal Sarcoma with MDM2 Amplification: An Open-Label Phase Ib/II Study
Authors: Koyama Takafumi , Shimizu Toshio , Kojima Yuki , Sudo Kazuki , Okuma Hitomi Sumiyoshi , Shimoi Tatsunori , Ichikawa Hitoshi , Kohsaka Shinji , Sadachi Ryo , Hirakawa Akihiro , Yoshida Akihiko , Ando Reiko Makihara , Ueno Toshihide , Yanagaki Mitsuru , Matsui Naoko , Nakamura Kenichi , Yamamoto Noboru , Yonemori Kan
Published: July 2023

Anti-tumor activity
Figure S8 from Dual Blockade of EP2 and EP4 Signaling is Required for Optimal Immune Activation and Anti-Tumor Activity Against Prostaglandin-Expressing Tumors
Authors: Francica Brian J. , Holtz Anja , Lopez Justine M , Freund David , Chen Austin , Wang Dingzhi , Powell David , Kipper Franciele C , Panigrahy Dipak , DuBois Raymond N , Whiting Chan C. , Prasit Peppi , Dubensky Thomas W
Published: July 2023

: Co-regulated genes determined from RNA sequencing of hyperplasia in APCmin/+ mice treated with prostaglandin pathway targeted agents
Figure S6 from Dual Blockade of EP2 and EP4 Signaling is Required for Optimal Immune Activation and Anti-Tumor Activity Against Prostaglandin-Expressing Tumors
Authors: Francica Brian J. , Holtz Anja , Lopez Justine M , Freund David , Chen Austin , Wang Dingzhi , Powell David , Kipper Franciele C , Panigrahy Dipak , DuBois Raymond N , Whiting Chan C. , Prasit Peppi , Dubensky Thomas W
Published: July 2023

TPST-1495 displays little tumor cell cytotoxicity in vitro at pharmacologically relevant concentrations
Figure S5 from Dual Blockade of EP2 and EP4 Signaling is Required for Optimal Immune Activation and Anti-Tumor Activity Against Prostaglandin-Expressing Tumors
Authors: Francica Brian J. , Holtz Anja , Lopez Justine M , Freund David , Chen Austin , Wang Dingzhi , Powell David , Kipper Franciele C , Panigrahy Dipak , DuBois Raymond N , Whiting Chan C. , Prasit Peppi , Dubensky Thomas W
Published: July 2023

Increased efficacy with TPST-1495 and α-PD-1 combination therapy in CT26 model.
Supplementary Table 4 from Exploring the onset and progression of prostate cancer through a multicellular agent-based model
Authors: Passier Margot , van Genderen Maisa N.G. , Zaalberg Anniek , Kneppers Jeroen , Bekers Elise M , Bergman Andries M , Zwart Wilbert , Eduati Federica
Published: July 2023

Percentages of cancer in model simulations
Supplementary Table 2 from Exploring the onset and progression of prostate cancer through a multicellular agent-based model
Authors: Passier Margot , van Genderen Maisa N.G. , Zaalberg Anniek , Kneppers Jeroen , Bekers Elise M , Bergman Andries M , Zwart Wilbert , Eduati Federica
Published: July 2023

List of model parameters
Supplementary Table 1 from Exploring the onset and progression of prostate cancer through a multicellular agent-based model
Authors: Passier Margot , van Genderen Maisa N.G. , Zaalberg Anniek , Kneppers Jeroen , Bekers Elise M , Bergman Andries M , Zwart Wilbert , Eduati Federica
Published: July 2023

List of model assumptions
Supplementary Figure 3 from Exploring the onset and progression of prostate cancer through a multicellular agent-based model
Authors: Passier Margot , van Genderen Maisa N.G. , Zaalberg Anniek , Kneppers Jeroen , Bekers Elise M , Bergman Andries M , Zwart Wilbert , Eduati Federica
Published: July 2023

Sensitivity analysis of the most sensitive model parameters
Supplementary Figure 2 from Exploring the onset and progression of prostate cancer through a multicellular agent-based model
Authors: Passier Margot , van Genderen Maisa N.G. , Zaalberg Anniek , Kneppers Jeroen , Bekers Elise M , Bergman Andries M , Zwart Wilbert , Eduati Federica
Published: July 2023

Comparison of cancer and non-cancer simulations
Data from Dual Blockade of EP2 and EP4 Signaling is Required for Optimal Immune Activation and Anti-Tumor Activity Against Prostaglandin-Expressing Tumors
Authors: Francica Brian J. , Holtz Anja , Lopez Justine M , Freund David , Chen Austin , Wang Dingzhi , Powell David , Kipper Franciele C , Panigrahy Dipak , DuBois Raymond N , Whiting Chan C. , Prasit Peppi , Dubensky Thomas W
Published: July 2023

Abstract
While the role of prostaglandin E2 (PGE2) in promoting malignant progression is well-established, how to optimally block the activity of PGE2 signaling remains to be demonstrated. Clinical trials with prostaglandin pathway targeted agents have shown activity but without sufficient significance or dose-limiting toxicities that have prevented approval. PGE2 signals through four receptors (EP1-4) to modulate tumor progression. EP2 and EP4 signaling exacerbates tumor pathology and is immunosuppressive through potentiating cAMP production. EP1 and EP3 signaling has the opposite effect through increasing IP3 and decreasing cAMP. Using available single small molecule antagonists of EP receptors, the COX-2 inhibitor celecoxib and a dual EP2/EP4 antagonist generated in this investigation, we tested which approach to block PGE2 signaling optimally restored immunologic activity in mouse and human immune cells and antitumor activity in syngeneic, spontaneous and xenograft tumor models. We found that dual antagonism of EP2 and EP4 together significantly enhanced the activation of PGE2-suppressed mouse and human monocytes and CD8+ T cells in vitro as compared to single EP antagonists. CD8+ T cell activation was dampened by single EP1 and EP3 antagonists. Dual EP2/EP4 PGE2 receptor antagonists increased TME lymphocyte infiltration and significantly reduced disease burden in multiple tumor models, including in the adenomatous polyposis coli (APC)min+/- spontaneous colorectal tumor model, compared to celecoxib. These results support a hypothesis that redundancy of EP2 and EP4 receptor signaling necessitates a therapeutic strategy of dual blockade of EP2 and EP4. Here we describe TPST-1495, a first-in-class orally available small molecule dual EP2/EP4 antagonist.
A controvérsia sobre as estradas paralelas de Glen Roy: uma justificação dos procedimentos de Darwin
Authors: Silva Marcos Rodrigues da
Published: July 2023

Uma importante categoria filosófica conceitual para a compreensão de uma produção científica é a noção de autoridade cognitiva; autoridades atuam como agentes causais de certas produções científicas. A historiografia costuma dar muita atenção a influências que redundam em casos de sucesso científico. No entanto, há um caso na história da biologia em que o uso de autoridades cognitivas resultou em um fracasso teórico: a derrota de Charles Darwin (1809-1882) para o geólogo suíço Louis Agassiz, (1807-1873) na controvérsia sobre as “estradas paralelas de Glen Roy”, um fenômeno geológico natural que se tornou um problema científico. Darwin, em suas investigações, empregou diversas autoridades cognitivas como por exemplo, William Whewell (1794-1866) e Charles Lyell (1797-1875) e considerou várias hipóteses, mas não a de Agassiz, já disponível na literatura, fazendo uso do “princípio da exclusão”. O objetivo deste artigo é mostrar que Darwin estava justificado em proceder como procedeu, devido exatamente às suas fontes, autoridades impecáveis em ciência.
Editorial
Authors: Martins Lilian Al-Chueyr Pereira , Prestes Maria Elice de Brzezinski
Published: July 2023

Editorial da revista.
Montagem, realismo, modernidade: uma leitura de Berlin Alexanderplatz, de Alfred Dōblin, à luz de considerações de Walter Benjamin
Authors: Rivetti Lara Cristina Casares
Published: July 2023

Este artigo tem por objetivo oferecer uma análise do romance Berlin Alexanderplatz, do escritor alemão Alfred Döblin, publicado em 1929, à luz das considerações feitas por Walter Benjamin em seu texto “A crise do romance - Sobre Berlin Alexanderplatz, de Döblin (1930)”. A partir de comentários iniciais a respeito do narrador do livro, examinamos qual o papel desempenhado pela montagem, enquanto recurso formal, na estrutura da obra e as consequências que seu uso traz à forma do romance, sobretudo no que diz respeito à constituição da voz narrativa. Para tanto, será realizada uma breve introdução à teoria do conceito de montagem, que desemboca com a sugestão de relações possíveis entre o livro de Döblin e o dadaísmo berlinense, com fins a delinear os contornos do ambiente no qual o romance foi escrito, sinalizando sua pertinência, a um só tempo, às questões mais prementes da época e aos anseios pela renovação da forma romanesca no início do século XX. Ao longo de todo o texto, será abordada a relação complexa entre Berlin Alexanderplatz e a tradição realista na literatura.
Uma cena de Fausto
Authors: Púchkin Aleksandr , Mendes Neto Joaquim Ferreira
Published: July 2023

O assunto fáustico atravessa a obra de Púchkin. Ainda que o autor não tenha tido contato com a segunda parte da tragédia de Goethe, é possível enxergar inúmeros paralelismos do “fomentador” Fausto, nas palavras de Marshall Berman, em O Cavaleiro de Bronze. Em “Uma cena de Fausto”, Púchkin recorre a alguns motivos da história do homem que vendeu a alma ao diabo, os principais são: o esquecimento e o tédio do homem sem limites. Este que é ampliado na composição de Púchkin, para representar, como é típico do autor, temas estrangeiros tendo em vista necessidades históricas do seu país. Na presente tradução, optou-se por uma versão prosaica da “Cena de Fausto”.
Khadijah (Maëlys)
Authors: Ruffato Luiz
Published: July 2023

Um conto de Luiz Ruffato.
Reimagining the Istanbul Encampment of 2013
Authors: Kolluoglu Poyraz
Published: July 2023

This article rests upon two kinds of deductions: first a lack of scholarly engagement within cultural constructs of religion in mainstream social movement studies; and the second, the quasi-religious aspects of occupy-like movement. These two problematics, one theoretical, and one ethnographic, are drawn together through Edith Turner’s conceptualization of communitas in light of the fieldwork findings derived from the encampment established at Istanbul’s Gezi Park in 2013.
On the interaction between metaphors and sentiment polarities
Authors: Duann Ren-feng
Published: July 2023

This study investigates Facebook posts related to ‘校正回歸 retrospective adjustment; to backlog’, a neologism coined during the first outbreak of COVID-19 in Taiwan in May 2021. It identifies 19 linguistic metaphors used to refer to this neologism; these are classified into the following eight metaphor groups: financial statements, lie, propaganda, recreation, scoundrel, straw, traffic congestion and tricks; among these, traffic congestion and recreation groups occur in posts of diverging polarities; the remaining six groups occur in posts exclusively expressing negative evaluation. Moreover, this study identifies a rhetorical strategy, parallelism, which occurs exclusively in the negative polarity and triggers a negative interpretation of value-neutral metaphors. Considering the aspects highlighted via the use of certain metaphors, it predicts that, for the conceptualisation of this neologism, objective metaphors are more likely to be used when the emphasis is on things that occur without the involvement of any agent’s volition; subjective metaphors are more likely to be used when the user emphasises the agent’s volition underlying a behaviour, including the manipulation of the number of infected patients, concealment of the truth, and transmission of false information.