bluuebunny/crossref_metadata_2025 huggingface dataset:
Tissue-Specific Variation in Aquaporins and Cytokines Transcriptional Profiles in Piglets being LPS Challenged
Authors: Silva Inês V. da , Coelho Diogo , Prates José António Mestre , Soveral Graça , Lopes Paula A.
Published: July 2023

Background: Lipopolysaccharide (LPS), an effective stimulator of the immune system, has been widely applied in an experimental pig model for human sepsis. Aquaporins (AQPs), a family of small integral membrane proteins responsible for facilitating water fluxes through the cell membrane, offer potential promising drug targets for sepsis treatment due to their role in water balance and inflammation. Methods: In order to investigate the potential effect of a dietary amino acid mixture supplementation on LPS-challenged weaned piglets, a total of 30, 28-day-old, males were randomly allocated to 1 of 3 dietary treatments for a 5-week period, with 10 animals in each: diet 1 was a control (CTL) treatment; diet 2 was LPS treatment, where the piglets were intraperitoneally administered LPS (at 25 µg/kg body weight); diet 3 was LPS + cocktail treatment, where the piglets were intraperitoneally administered LPS and fed a diet supplemented with a mixture of arginine, branched-chain amino acids (BCAA, leucine, valine, and isoleucine), and cystine. Key organs that control sepsis were collected and processed by real time quantitative PCR (RT-qPCR) for the AQPs and cytokines transcriptional profiles. Results: Minor variations were detected for AQPs and inflammatory markers mRNA levels, upon the dependence of LPS or the amino acid cocktail suggesting the piglets’ immune recovery. Using a discriminant analysis tool, we report for the first time, a tissue-specific variation in AQPs and cytokines transcriptional profiles that clearly distinguish the small intestine and the kidney from the liver and the spleen. Conclusions: This study provides a novel insight into the gene expression signature of AQPs and cytokines in the functional physiology of each organ in piglets.
Proline cis/trans Isomerization in Intrinsically Disordered Proteins and Peptides
Authors: Sebák Fanni , Szolomájer János , Papp Nándor , Tóth Gábor K. , Bodor Andrea
Published: July 2023

Background: Intrinsically disordered proteins and protein regions (IDPs/IDRs) are important in diverse biological processes. Lacking a stable secondary structure, they display an ensemble of conformations. One factor contributing to this conformational heterogeneity is the proline cis/trans isomerization. The knowledge and value of a given cis/trans proline ratio are paramount, as the different conformational states can be responsible for different biological functions. Nuclear Magnetic Resonance (NMR) spectroscopy is the only method to characterize the two co-existing isomers on an atomic level, and only a few works report on these data. Methods: After collecting the available experimental literature findings, we conducted a statistical analysis regarding the influence of the neighboring amino acid types (i ± 4 regions) on forming a cis-Pro isomer. Based on this, several regularities were formulated. NMR spectroscopy was then used to define the cis-Pro content on model peptides and desired point mutations. Results: Analysis of NMR spectra prove the dependence of the cis-Pro content on the type of the neighboring amino acid—with special attention on aromatic and positively charged sidechains. Conclusions: Our results may benefit the design of protein regions with a given cis-Pro content, and contribute to a better understanding of the roles and functions of IDPs.
New Insights into Extracellular Vesicles between Adipocytes and Breast Cancer Orchestrating Tumor Progression
Authors: Cui Jing , Shen Weida , Zhao Haiyan
Published: July 2023

In recent years, obesity has been widely considered an independent risk factor for diseases/disorders including inflammation, cardiovascular disease, and cancer. Adipocytes separate in diverse types of tissues, playing vital roles in not only homeostasis but also disease progression. Adipose tissue is not only an energy organ but is also an endocrine organ that can communicate with other cells in the microenvironment. In this review, we assess the functions of breast cancer-associated adipose tissue-derived extracellular vesicles (EVs) in the progression of breast cancer including proliferation, metastasis, drug resistance, and immune regulation. A better understanding of the role of EVs in the crosstalk between adipocytes and breast cancer will provide an understanding of the cancer biology and progression, which would further drive improvements of diagnostic strategies as well as therapeutic insights.
CRISPR/Cas9-Mediated Gene Correction in Osteopetrosis Patient-Derived iPSCs
Authors: Li Dandan , Ou Minglin , Zhang Wei , Luo Qi , Cai Wanxia , Mo Chune , Liang Wenken , Dai Guandong , Yin Lianghong , Zhu Peng , Tang Donge , Dai Yong
Published: July 2023

Background: Osteopetrosis represents a rare genetic disease with a wide range of clinical and genetic heterogeneity, which results from osteoclast failure. Although up to 10 genes have been identified to be related with osteopetrosis, the pathogenesis of osteopetrosis remains foggy. Disease-specific induced pluripotent stem cells (iPSCs) and gene-corrected disease specific iPSCs provide a platform to generate attractive in vitro disease cell models and isogenic control cellular models respectively. The purpose of this study is to rescue the disease causative mutation in osteopetrosis specific induced pluripotent stem cells and provide isogenic control cellular models. Methods: Based on our previously established osteopetrosis-specific iPSCs (ADO2-iPSCs), we repaired the point mutation R286W of the CLCN7 gene in ADO2-iPSCs by the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) mediated homologous recombination. Results: The obtained gene corrected ADO2-iPSCs (GC-ADO2-iPSCs) were characterized in terms of hESC-like morphology, a normal karyotype, expression of pluripotency markers, homozygous repaired sequence of CLCN7 gene, and the ability to differentiate into cells of three germ layers. Conclusions: We successfully corrected the point mutation R286W of the CLCN7 gene in ADO2-iPSCs. This isogenic iPSC line is an ideal control cell model for deciphering the pathogenesis of osteopetrosis in future studies.
Ethical Leadership in organisation. A literature review paper _Edited by Umaru_Updatred.docx
Authors: Wirba Asan Vernyuy
Published: July 2023

  

This research study highlights the critical significance of ethical leadership within organizations and business institutions, particularly considering the increasing number of scandals that have occurred across various sectors. The researcher's motivation to investigate the need for ethical leadership stems from the widespread concerns surrounding unethical leadership, which has garnered significant attention due to scandals in both business organizations and religious institutions. Numerous studies have concluded that ethical leaders are characterized by their fairness, balanced decision-making, honesty, kindness, and principled behaviour. These leaders not only establish clear ethical standards but also utilize incentives and punishments to foster compliance. Moreover, ethical leaders consistently engage their followers in discussions about ethics. 
Neutrophil-lymphocyte and leuko-glycemic indices as predictive markers for ventilatory support in patients with Guillain-Barre syndrome
Authors: Vargas Cañas Edwin Steven , Hernandez Sanchez Miriam Marcela , Galnares Olalde Javier Andres , Jorge de Sarachaga Adib , Bazán Rodríguez Ana Lissette , May Mas Raul Nathanael , López-Hernández Juan Carlos
Published: July 2023

Background:  Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis worldwide. Lymphocytes and neutrophils are associated with systemic inflammation and production of proinflammatory mediators. GBS, as an autoimmune disease, elicits an upregulation in inflammatory and metabolic pathways, with increased production of lymphocytes and neutrophils. Serum markers such as the neutrophil-lymphocyte (NLR) and leuko-glycemic (LGR) ratios have been studied for the severity and prognosis of non-neurological disorders.
Methods: A cross-sectional study from a prospective cohort of patients with GBS was conducted, from January 2018 to February 2021. Comparison between patients with or without ventilatory support was performed with student´s t test or Mann-Whitney U test based on distribution. Chi-square for was used for categorical variables, Fisher´s exact test was applied when necessary. A logistic regression analysis was performed.
Results:  One hundred and twenty-three patients were included. Logistic regression analysis demonstrated NLI to be an independent factor for mechanical ventilation in GBS, but not for LGI and OR 2.0, respectively. Both LGI and NLI demonstrated a high performance for ventilatory support prediction, with 0.70 and 0.81, respectively. Best cut-off values, according to Youden index, are for LGI 1.12 (sensitivity 0.70, specificity 0.40) and for NLI 3.59 (sensitivity 0.78, specificity 0.33). 
Conclusions:  Despite the wide use of the EGRIS scale in estimating respiratory insufficiency in patients with GBS, we portray a new and easy to obtain laboratory tool that can further help non-neurologists and other clinicians to predict the risk for ventilatory support.
Comparative Efficacy of First and Second Generation long-acting injectable antipsychotic upon schizophrenic patients: a systematic review and network meta-analysis
Authors: Sauceo-Uribe Erasmo , Gonzalez-Mallozzi Pedro Jehu , Medrano-Garza Raúl Ricardo , Diaz Gonzalez-Colmenero Fernando , Carranza-Navarro Farid , Castillo-Morales Patricia Lizeth , Leyva-Camacho Paloma , Herrera-Montemayor Yessica , Vidal-Tijerina Mauricio , Enriquez-Navarro Moises Karika , Medrano Samantha B. , Fernandez-Zambrano Stefan Mauricio , Mancias-Guerra Claudia Magdalena , Saucedo-Mancias Claudia Lizeth , Sanchez-Ramirez Manuel Ramiro
Published: July 2023

Introduction: Long-acting injectable antipsychotics (LAIA) can lead the course of treatment with the potential to increase adherence in schizophrenia treatment. The objective of this systematic review and network meta-analysis is to find the efficacy of SG-LAIAs, FG-LAIAs compared to each other for schizophrenia.
Methods: This systematic review and network meta-analysis was designed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), with registration in Prospero (ID CRD42019128700). A database in MEDLINE, EMBASE, Web of Science, and Scopus, until June 17, 2020, with an actualization from June 2020 to September 14, 2021. 
Results: The SMDs for the four (80%) antipsychotics that significantly reduced PANSS score compared with placebo ranged between –0·72 (95% CrI –0·99 to –0·46) for haloperidol to –0·45 (–0·54 to –0·37) for paliperidone. 8 studies reported usable results for negative symptoms and positive symptoms (Four antipsychotics compared). The SMDs for the three (75%) antipsychotics that significantly reduced negative symptoms compared with placebo ranged between –0·40 (95% CrI –0·53 to –0·26) for aripiprazole to –0·32 (–0·44 to –0·19) for risperidone. The SMDs for the three (100%) drugs that significantly reduced positive symptoms compared with placebo ranged between –0·50 (95% CrI –0·63 to –0·37) for aripiprazole to –0·19 (–0·57 to 0·20) for zuclopenthixol.
Discussion: We found evidence suggesting that all long-acting injectable antipsychotics, except for zuclopenthixol, are equally efficient in reducing symptoms in schizophrenia,
Conclusions: Most LAIAs are equally efficient at reducing overall symptoms, and differences between individual LAIAs are non-significant.
تخطيط المدن في مصر الاسلامية الفسطاط انموذجاً
Authors: وفاء عدنان حميد ا.د. , الاء حماد رجه ا.م.د.
Published: July 2023

للوقوف على اهم انجازات الدولة الاسلامية و التي ساهمت بتوسعها فقد  نشأت حاجة حقيقية الى انشاء عدد من المدن و التي اصبحت عواصم للدولة الاسلامة  و كذلك حواضر للمدن المحيطة، في بحثنا هذا نستعرض اهم المدن التي انشات في الدولة الاسلامية، و عملية اختيار التخطيط الملائم لها و الذي يعد الاساس في نجاح تلك المدن، و هناك عدد من العوامل التي تاخذ في الحسبان عند تخطيط المدن.

هناك عدد من المؤثرات في اختيار مواقع المدن الإسلامية تختلفت طبيعتها من مدينة إلى أخرى لا سيما تلك العوامل المرتبطة بالنواحي الحربية أو السياسية واتفقت في توافر شروط أساسية وجب توافرها بصفة عامة في اختيار أي موقع. وتتردد هذه الشروط بصيغة أو بأخرى في المصادر الجغرافية التي تتحدث عن مواقع المدن وصفاتها الحسنة.

يعد المسجد المحور الرئيس الذي يكون وسط المدينة ليشكل نواة التغيير العمراني. ثم شقت طرق رئيسية تصل المسجد بالضواحي، ومن الامثلة على ابرز المدن الاسلامية التي انشأها العرب المسلمون عديدة منها خارج شبه الجزيرة العربية, أهمها البصرة, الكوفة, الفسطاط, القيروان, بغداد, سامراء والقاهرة, وقد تميزت هذه المدن بمعالم ميزتها عن المدن الأخرى.

اقتضت طبيعة البحث تقسيمه على مقدمة عن طبيعة تخطيط المدن في الدولة العربية الاسلامية. ثم تطرقنا في المبحث الاول عن الاسباب والغايات الرئيسة لانشاء المدن الاسلامية المدن خارج شبه الجزيرة العربية. وشمل المبحث الثاني عن معالم المدن الاسلامية التي تميزت بها  المدينة الإسلامية بمعالم كثيرة كان لها دور كبير في الحياة الدينية والاجتماعية والاقتصادية والسياسية والثقافية والصحية في المجتمع الإسلامي. والمبحث الثالث المدن في الدولة اللعربية الاسلامية ( الفسطاط )، في حين عالج المبحث الرابع تخطيط مدينة الفسطاط. ثم ختم البحث بمجموعة من النتائج التي توصل اليه البحث.

الكلمات المفتاحية: بناء كفاءة الترجمة، الكفاءات الفرعية لكفاءة الترجمة، الكفاءة التواصلية للكتابة،

تصميم دورة الكتابة، نموذج تقييم الكتابة
تاثير تمرينات مهارية مركبة في تطويربعض القدرات البدنية ومستوى الاداء المهاري المركب للاعبي كرة القدم
Authors: حسين فراس
Published: July 2023

تكمن اهمية البحث في التعرف على التمرينات المهارية المركبة واثرها في تطوير بعض القدرات البدنية ومستوى الاداء المهاري المركب والسعي لايجاد افضل الطرق والاساليب لتطويرها بوصفها احدى اهم متطلبات اللعب الخاصة للاعبين حيث ان اللاعبين الذين يمتلكون قدرات بدنية ومهارية عالية يكونوا اكثر مقدرة على تنفيذ ما مطلوب منهم اثناء المباريات ويعطوا لمدربيهم فرص اكبر في اختيار نوع الخطة وطريقة اللعب  , ويهدف البحث الى اعداد تمرينات مهارية مركبة لتطوير بعض القدرات البدنية ومستوى الاداء المهاري المركب للاعبي كرة القدم , ويفرض الباحث وجود فروق ذات دلالة احصائية مابين الاختبار القبلي والبعدي للقدرات البدنية قيد الدراسة ومستوى الاداء المهاري المركب ولصالح الاختبار البعدي , واستخدم الباحث المنهج التجريبي بتصميم المجموعتين المتكافئتين (الضابطة والتجربية) ذات الاختبارين القبلي والبعدي لملاءمة طبيعة مشكلة البحث , تكونت عينة البحث من لاعب نادي الرائد بكرة القدم والبالغ عددهم (16) لاعب تم تقسيمهم بطريقة عشوائية الى مجموعتين (ضابطة وتجريبية) كل مجموعة تكونت من (8) لاعبين , واستنتج الباحث الى ان للتمرينات المهارية المركبة تاثر ايجابي في تطوير القدرات البدنية المستخدمة ومستوى الاداء المهاري المركب , ويوصي الباحث الى التاكيد على استخدام التمارين المهارية المركبة لما لها من اثر في تطوير الاداء المهاري للاعبي كرة القدم , والى التاكيد على تطوير القدرات البدنية للاعبي كرة القدم لما لها من اثر عند اداء المهارات الاساسية للاعبي كرة القدم , والى تقنين البرامج التدريبية على وفق الاسس العلمية و اعتماد المؤشرات الوظيفية اساساً لتحديد الاحمال وفترات الراحة .
Resume Kebijakan Moneter Perspektif Islam
Authors: Ali Nurfadilla Nur
Published: July 2023

Tulisan ini dibuat untuk memenuhi tugas dari mata kuliah ekonomi mikro yang memuat tentang materi yang telah disampaikan dan didiskusikan di kelas bersama dosen kami. Dalam tulisan ini memuat pengenalan singkat mengenai materi "Kebijakan Moneter Perspektif Islam", Penulis berharap bisa membantu pembaca dalam menambah wawasan dan penulis juga menyadari bahwa apa yang ada didalam tulisan ini masih belum memuat semua informasi yang ada tentang judul materi yang telah disebutkan sebelumnya.
Instrumen Dan Komponen Kebijakan Fiskal Islami
Authors: AR Ashra
Published: July 2023

Instrumen kebijakan fiskal dalam ekonomi Islam berasal dari zakat, infaq,sedekah dan wakaf. Unsur tersebut ada yang bersifat wajib dan ada juga yang bersifat sukarela. Zakat merupakan unsur yang harus dibayarkan oleh wajib pajak setelah mencapai nisabnya, sedangkan infaq, sedekah dan wakaf bersifat sukarela.
Integrating Biopsychosocial Approaches in the Management of Low-Back Pain: A Comprehensive Review
Authors: Harifat Huxley
Published: July 2023

This comprehensive review explores the integration of biopsychosocial approaches in the management of low-back pain (LBP). LBP is a multifaceted condition influenced by biological, psychological, and social factors. The review examines the evidence supporting the biopsychosocial model of LBP, the impact of biopsychosocial factors on pain perception and disability, and the effectiveness of integrated interventions. Emphasizing a holistic approach, the review highlights the importance of addressing biological, psychological, and social aspects in LBP management to optimize outcomes and improve the overall well-being of individuals with LBP.
Model Analisa IS- LM dalam Perspektif Islam
Authors: AR Ashra
Published: July 2023

Keseimbangan IS-LM merupakan bagian untuk menurunkan kurva agreggate demand (AD) yang menunjukkan total permintaan barang dan jasa dalam suatu perekonomian. Bagan di bawah in menjelaskan bagaimana penurunan kurva AD dan perpotongan IS-L.M.
Momentum Melayani Sesama
Authors: Qosim Nanang
Published: July 2023

Setiap muslim sejatinya tidak hanya menjadikan agama sebagai peristiwa ritual belaka, melainkan juga sebagai perhelatan yang bernuansa sosial sehingga mampu menumbuhkan kepedulian sosial. Menurut Peter L Berger, setiap agama harus melahirkan voluntarisme, yaitu kesukarelaan untuk melayani sesama manusia.Agama tidak pada tempatnya jika hanya menumbuhkan sikap fanatis dan fundamentalistis, karena setiap agama pada hakikatnya merupakan instrumen untuk memupuk kesadaran pentingnya saling berbagi di antara sesama makhluk manusia.
Instrumen dan komponen kebijakan fiskal islami
Authors: Ali Nurfadilla Nur
Published: July 2023

Tulisan ini dibuat untuk memenuhi tugas dari mata kuliah ekonomi mikro yang memuat tentang materi yang telah disampaikan dan didiskusikan di kelas bersama dosen kami. Dalam tulisan ini memuat pengenalan singkat mengenai materi "Instrumen dan komponen kebijakan fiskal islami", Penulis berharap bisa membantu pembaca dalam menambah wawasan dan penulis juga menyadari bahwa apa yang ada didalam tulisan ini masih belum memuat semua informasi yang ada tentang judul materi yang telah disebutkan sebelumnya.
Kebijakan Pendapatan dan Kebijakan Belanja Ekonomi Islam
Authors: Waasi Nur
Published: July 2023

Islam telah menetapkan sektor-sektor penerimaan pemerintah melalui zakat, ghanimah, fai, jizyah, kharaj, shadaqah, dan lain-lain. Jika diklasifikasikan maka pendapatan tersebut ada yang bersifat rutin seperti: zakat, jizyah, kharaj, ushr, infak dan shadaqah serta pajak jika diperlukan, dan ada yang bersifat temporer seperti: ghanimah, fa’i dan harta yang tidak ada pewarisnya.
Prothrombotic factors associated with COVID-19 complications: A systematic review preprint.
Authors: Avellar Boaz
Published: July 2023

BACKGROUND: The COVID-19 pandemic caused deaths and severe clinical complications associated with thrombosis and hypercoagulability, motivating this literature review. OBJECTIVE: To analyze the scope of scientific publications that demonstrate an association of thromboembolism with complications of COVID-19. METHOD: A systematic literature review was performed to identify clinical complications associated with thrombosis in people exposed to SARS-CoV-2 infection. The articles were selected from MEDLINE database after being screened and filtered to extract the methodologies used and the evidence of clinical complications by compromised organs or systems and pathology description. The evidence was extracted in Cohort Studies for statistical analysis and hypothesis testing (t-test). RESULTS: A total of 208 studies were selected. Observational Studies were predominant, corresponding to 64% of the total, and other methodologies corresponded to 9% in the inclusion. Review articles were excluded and corresponded to the remaining 27% of the selected articles. Subsequently, 150 articles were screened, and 121 were filtered. Among these, 11 Cohort Studies were extracted as the sample, which were eligible for analysis and subsequent Hypothesis Test. This test showed a Mean Difference of 4.74 [Ha (μ=8.08 Exposure) > (μ=3.33 No exposure)], with a p-value of 0.096 for a 95% confidence interval. Despite the numerical value of the difference in the means due to the influence of variance, the test result was not statistically significant due to the small number of the sample of Cohort studies. CONCLUSION: It was observed that prothrombotic conditions were present and translated by hypercoagulability in the evaluated articles. Individuals exposed to SARS-CoV-2 infection have been shown to experience complications caused by thrombosis more often than the unexposed. It is suggested to conduct a Meta-analysis with a larger sample of Cohort Studies to further analyze this association.
On Newtonian knot in (2+1)-dimensional empty space-time
Authors: Hadi Miftachul
Published: July 2023

We propose the existence of a topological object, a Newtonian knot, in the framework of an Abelian Chern-Simons action with a small positive cosmological constant in (2+1)-dimensional empty space-time. It is based on the proposal that the Ricci curvature tensor could consist of a set of curvature components that satisfies the non-trivial Hopf maps. We derive the corresponding field equations and propose ansatz for the dreibein and spin connection as solutions.
The Economic Burden of Low-Back Pain: A Cost Analysis in the United States
Authors: Harifat Huxley
Published: July 2023

This study aims to assess the economic burden of low-back pain (LBP) in the United States through a comprehensive cost analysis. LBP is a prevalent condition associated with substantial healthcare utilization, productivity losses, and direct and indirect costs. The analysis includes healthcare costs, productivity losses, and associated expenditures related to LBP management. The findings provide valuable insights into the economic impact of LBP, highlighting the need for effective strategies to reduce the burden on individuals, healthcare systems, and society as a whole.
Information structure model of natural stimuli source
Authors: Chuang Gao , Shiyin Kang , Ma Anran
Published: July 2023

Natural stimuli are initial information source for human cognitive processing. This notion has been accepted and commonly used for long time, however, it seldom was defined in psychology and physiology for its unknown information structure.In this paper, we propose a formula of object’s property information structure, which together with the event information structure formula proposed previously can completely express natural stimuli. Based on this, the nature of stimuli variable has been reconsidered in the classical experimental field of psychophysics, perception, learning and language by using the formula element variables. It was shown that in spite of stimuli diverse form, stimuli can be expressed by stimuli formula elements.This framework reveals an underlying stimuli structure rooted in human processing pattern SOR. It indicates that a mathematical standard for stimuli expression should be adopted. And beyond of this, all stimulus processing theories should be reconsidered, promoted or revised, for stimuli also are objective contents processed by cognition systems. It will be a revolution for cognitive processing and unified psychology.
How do we evaluate others’ memories? A behavioral and natural language processing study
Authors: Gamoran Avi , lieberman lilach , Gilead Michael , Dobbins Ian , Sadeh Talya
Published: July 2023

Humans have the highly adaptive ability to learn from others’ memories. However, because memories are prone to errors, in order for others’ memories to be a valuable source of information, we need to assess their veracity. Previous studies have shown that linguistic information conveyed in self-reported justifications can be used to train a machine-learner to distinguish true from false memories. But do humans process this information in the same way the model does? Participants were presented with justifications corresponding to Hits and False-Alarms and were asked to assess whether the witness’s recognition was correct or incorrect. Results show that human evaluators can discriminate Hits from False Alarms above chance levels, based on the justifications provided per item. Classification using indirect measures (Confidence, Opinion-ratings) outperformed evaluators’ explicit classification. Predictions from the indirect classification model shared only a portion of the variance with the predictions of the machine learning language-based model. Hence, features generated from humans’ assessments augmented the language-based models, with the model combining both humans’ and the machine-learner’s classifications outperforming each model individually.
Lack of optimistic biases in depression and social anxiety is reflected in reduced positive self-beliefs, but distinct processing of social feedback
Authors: Hoffmann Janina A , Hobbs Catherine , Moutoussis Michael , Button Katherine Susan
Published: July 2023

Processing social feedback optimistically helps maintain a positive self-image and stable social relationships. Individuals with depression and social anxiety often lack this optimistic bias. Yet, the cognitive routes over which social feedback reinforces a negative self-image have remained largely unclear and may differ between depression and social anxiety. A reanalysis of previous studies (n = 450) and a pre-registered replication (n = 807) demonstrated that self-reported depressive symptoms and social anxiety were associated with better learning of negative social evaluations about the self, relative to positive evaluations, in a computerised social evaluation task. Transdiagnostically, this asymmetry was driven by reduced positive trait-like beliefs. Yet, in social anxiety, this bias reflected a heightened sensitivity to negative social feedback, whereas in depression it co-existed with a blunted response to social feedback. Recognising such differences in feedback processing may inform approaches to personalizing treatment.
Malaysian Media Coverage of Palestinian Presidents’ Image during Crises 1996-2016
Authors: Arandas Mohammed Fadel
Published: July 2023

Maintaining a good image of political leaders is significant to ensure their political life. The image of political leaders, including presidents of any country, is threatened when they are facing critical situations. This study examines the coverage by the Malaysian media, specifically New Straits Times (NST), on the Palestinian Presidents, Yasser Arafat and Mahmoud Abbas and their portrayal towards several crises. Both image repair theory and framing perspective were used to guide the study. A total of 2715 news stories have been found about Palestinian issues in the 21 year period covered from 1996-2016. A total of 531 stories were related to Palestinian Presidents, 456 stories were on crises. This study employing content analysis has revealed three main crises faced by the Palestinian Presidents, namely political, social, and economic crisis. The political crises included: peace process, internal conflict, foreign pressure, Israeli attacks, Israeli blockade, Palestinian attacks, Israeli threats, clashes, demonstrations, Israeli spying, kidnapping, and relations breakdown. The social crises included: corruption, information leakage, cheating, false information, Israeli rumours, and Israeli slanders. The economic crises included only financial crisis. Palestinian Presidents have used all the main image repair strategies, namely denial, evasion of responsibility, reducing offensiveness, corrective action, and mortification.
Evaluating Refresher Training on Masters’ Course of Rural Development Subject
Authors: Khatri Bishnu Bahadur , Pasa Rajan Binayak
Published: July 2023

The refresher course training is pivotal for strengthening teachers’ commitment, sharing knowledge, increasing self-confidence, and keeping them up to date on current teaching learning activities. With this consideration, the aim of this paper is to assess the present syllabus of MA in Rural Development and evaluate the refresher course training program based on four levels of evaluation such as reaction, learning, behavior and result of the program. For that purpose, we purposively selected 25 participants who were associated in 21 campuses including Central Department. We applied survey based evaluation research method and Kirkpatrick four levels (reaction, learning, behavior and result) training evaluation model for assessing and examining outcomes of trainings. It reveals that the training program has evolved into an academic platform for students to share their personal experiences with course structure, teaching learning practices, and student performance. It has increased the capacity of the subject coordinators/teacher in terms of networking, course structure/function, performance assessment and constructivist pedagogy. Besides, they have developed a good network amongst the participants and resource persons. The major outputs of the program are SWOC analysis of course structure, 3Rs (Revisit, Revision and Restructure) course concept as well as list of lesson learn and new possible papers (course of study). Therefore, this short term training might brought long term impact improving course structure/function including pedagogical practices. Finally, course function scale, conceptual learning scale, Constructivist Pedagogy/learning theory scale, level four result/outcomes scale and characteristics of the participants are interlinked and associated significantly.
Use of English Teachers' Pedagogical Capital in the Classroom
Authors: Bastola Ganesh Kumar
Published: July 2023

This paper aims at exploring the uses and practices of English as a Foreign Language (EFL) Teachers pedagogical capital in the classroom. It examines how the use and usages of EFL teachers’ pedagogical capital affects the way they deal with their students in the language classroom. The research was grounded within the interpretive research paradigm. The in-depth unstructured interview and observation were the research tools under narrative inquiry design. The data were collected from three different participants and themes were substantiated by Clandinin and Connelly to replicate their voices and experiences. The research finding reveals that teachers’ profound knowledge and skills about their capital are useful to integrate various cultures and content in the classrooms. Pedagogically inbuilt potentials of teachers and their pedagogical capital maximally enhance learners’ learning opportunities and foster students’ potential. However, it contributes to teachers’ education by rationalizing the essence of teachers’ pedagogical knowledge to transform our ELT practice in Nepal.
A Theoretical Discourse on Quality Education
Authors: Panthee Shree Krishna
Published: July 2023

The theoretical and empirical dimensions and understandings of quality in education are explored in this study using secondary research techniques based on a literature review and content analysis. It reviews several studies and includes recommendations for top-notch instruction. While the quality of education is a current global problem, Nepal’s education is seen as being of poor quality. In order to guarantee quality education, numerous international conferences have been held. In Nepal, getting a good education is difficult and seen as a piecemeal process. Review shows that there are number of ways to ensure quality education. However, efficiency, effectiveness, equity, relevancy and sustainability are considered the basic measures for a quality education. Similarly, quality environment, quality inputs, quality contents, quality process, quality outputs, quality outcomes, and quality impacts are considered the basic imperatives of quality education. The main methods for achieving quality in diverse sectors include quality assurance, contract compliance, customer-driven, ISO 9000:2000, and self-assessment though the education experts and practitioners perceive quality education as an intangible and elusive notion.
देवकोटाको लूनी गीतिकाव्यमा ध्वनिवाद
Authors: कार्की Karki बिनोद Binod
Published: July 2023

Available with fulltext.
नेपाली तबलावादनमा रचनात्मकता
Authors: ढकाल Dhakal वेन्काटेश Wenkatesh
Published: July 2023

Available with fulltext.
उत्तरवर्ती नेपाली नारी–निबन्धमा नारीवादी चिन्तन
Authors: पन्त Pant साधना Sadhana
Published: July 2023

Available with fulltext.
Prevalence and factors influencing physical activity among secondary school adolescents: A cross-sectional study
Authors: Nepal Samata , Marhatta Anu , Shrestha Sajja , Karki Deelip Kumar
Published: July 2023

Introduction: Physical inactivity is a major health concern among adolescents and is an independent, modifiable risk factor for several non-communicable diseases. Despite the World Health Organization recommended physical activity levels, many adolescents do not meet these guidelines. This study was conducted among secondary school students in Palpa district of Nepal to assess their physical activity levels and associated factors.
Methods: A modified version of the Physical Activity Questionnaire Adolescents was used to collect data from 506 grade eight and nine students from six schools in Palpa district.
Results: The results revealed that only 25.31% of students engaged in physical activity quite often or always, and only 23.10% met the daily WHO recommendation of at least 60 minutes of physical activity per day. Additionally, females were less likely to achieve the recommended physical activity level compared with males.
Conclusions: The low levels of physical activity among secondary school students in Palpa district of Nepal highlight the need for interventions to promote physical activity. This study identified several factors associated with low physical activity levels, including limited break time at school, lack of parks or playgrounds near homes, and gender differences.
Complementary feeding practices among mothers of 6-23 months of aged children at a tertiary level hospital in Nepal
Authors: Ghimire Pratima , Pathak Pratima , Ghimire Bijaya , Poudel Pramila , Shrestha Kunja , Gachhadar Rashmi , Gauro Pooja
Published: July 2023

Introduction: Complementary feeding is defined as the process starting when breast milk is no longer sufficient to meet the nutritional requirements of infants then other foods and liquids are needed, along with breast milk. This study was conducted to assess the complementary feeding practice among mothers of 6-23 months of aged children.
Methods: A cross-sectional study was conducted in Kathmandu among 240 mothers of 6-23 months of aged children attending the pediatric outpatient department and community medicine from June to September, 2022. A purposive sampling technique was used and data were collected using a structured questionnaire through a face-to-face interview. The obtained data were entered into Epi-data and converted into Statistical Package for the Social Sciences-20. Descriptive and inferential statistics were used for statistical analysis.
Results: The prevalence of Minimum Dietary Diversity (MDD),Minimum Meal Frequency (MMF), and Minimum Acceptable Diet (MAD) was 49.16% (0.42-0.55, 95% Confidence Interval), 44.58% (0.48-0.61, 95% Confidence Interval) and 27.91% (0.65-0.77, 95% Confidence Interval) respectively. Children of age 18-23 months were statistically significantly associated with MDD, MMF, and MAD respectively. Type of family, listening to radio as media, along with breastfeeding and bottle feeding since six months were statistically significantly associated with MMF and along with breastfeeding as well as bottle feeding since birth to six months were statistically significantly associated with MAD.
Conclusions: This study concluded that the children aged 18-23 months were more likely to have recommended standard complementary feeding practices than other younger-aged groups.
Język sakralny wobec polskiego języka narodowego. Łacina
Authors: Sobczykowa Joanna
Published: July 2023

Artykuł dotyczy łaciny jako języka sakralnego w polskim obszarze kulturowym w historii i współcześnie. Szkicowo potraktowano w nim sytuację w innych obszarach kultury, takich jak semicki czy słowiański. Analizie zostały poddane status i funkcje łacińskiego języka liturgicznego w ujęciu historycznym i współcześnie – w odczuciu mówiących, teologów, językoznawców, filozofów religii. W tekście przedstawiono udokumentowanie łacińskiej twórczości średniowiecznych polskich kaznodziejów i troskę o rozumienie liturgii łacińskiej przez lud. Pokazano również rozpiętość między tendencjami do sakralizacji i desakralizacji, różnicę między rozumieniem werbalnym a duchowym, danym w rozmyślaniu.
Pengaruh Pupuk Bokashi Kanddang Ayam Terhadap Pertumbuhan Dan Produksi Bawang Merah (Allium Ascalonicum)
Authors: Umanailo Muhamad Chairul Basrun , Buton La Jati , Lestari Adyla Mita
Published: July 2023

The effort taken to increase shallot production both in quality and quantity is to use fertilizer. One type of organic fertilizer that will be used is bokashi chicken manure. Bokashi is a fermentation of organic matter by inoculation of EM4 which is a mixed culture of beneficial microorganisms for plant growth such as Lactobacillus sp, photosynthetic bacteria, actinomycetes and yeast. The purpose of this study was to determine the effect of cutting tubers and applying various doses of chicken manure bokashi on the growth and production of shallots. The method used was a randomized block design in the form of a two-factor factorial where the first factor was the cutting of the seed tubers (p) which consisted of without cutting the ends of the tubers (p1) and cutting the ends of the tubers (p2). The second factor was the treatment of several doses of chicken manure bokashi (b) which consisted of several levels, namely 2 kg of chicken manure bokashi/plot (b1), 4 kg of chicken manure bokashi/plot (b2) and 6 kg of chicken manure bokashi/plot. tile (b3). There was a significant interaction between cutting tubers and the dose of bokashi chicken manure 4 kg plot-1 which affected the growth of shallot plants
Future Mindedness in Single Middle Adult Women
Authors: Ekayanti Febby Listya , Nurchayati
Published: July 2023

This article examines future mindedness among single middle adult women. In line with the dominant culture, most parents in Indonesia rely on their children for support in old age. Some women, however, choose to remain single and childless. This article focuses its exploration on the ways in which these unmarried, childless women plan and prepare for their lives in old age. Using the case-study approach and employing, as its theoretical framework, Seginer’s concept of future mindedness, we collected our data through semi-structured interviews with four women, aged 42 to 55, who served as research participants. After triangulating the data, we interpreted it using the thematic analysis method. Our study produced four findings. First, comfortable with being single, three of the four women had no desire to marry. Second, taking a positive view of old age, and knowing fully well that their kinfolk will take care of them in their advanced years, all the four participants do not worry about old age. Third, none of their relatives has put pressure on them to marry. Fourth, personality and family support appear to play a key role in these women’s choice to live a life of celibacy. In sum, unmarried middle-aged women are happy with their status and have plans for life in old age, including where to live and how to get elderly care.
Public Perception of Health Insurance Technology-Based Innovation in Indonesia
Authors: Irawan Bambang , Putri Tasya Kamila , Zulkifli Zarina , Akbar Paisal
Published: July 2023

This study aims to obtain an overview and analyze public perceptions in implementing technology-based health insurance service innovations in the Mobile National Health Insurance (JKN) application conducted by the Indonesian Health Social Security Administration Agency (BPJS). This study used descriptive qualitative method. This research data is generated from the comments column of the JKN mobile application in the AppStore and Play Store. Data collection is done by data mining and data extraction. The data analysis used in this research is Qualitative Data Analytics (QDA). The analytical tool used in this study is Qualitative Data Software Analysis (QDSA) Nvivo 12 Plus. The results of the study show several things, namely the first is related to the features available in the Mobile JKN application. The second is related to the number of downloaders and the number of active users of the Mobile JKN application, and the third is related to the perception generated by users while using the Mobile JKN application. Where it was found that overall public perception of the application of technology-based health insurance service innovations through the JKN mobile application by the Indonesian BPJS Health obtained a perception that tended to be negative. This is shown by the five indicators that mostly get a bad perception from the public, and only two indicators that fully capture good or positive perceptions. Apart from that, other findings also show the dominant sentiment generated while this application is used by the public in obtaining health services.
Disaster Policy, Participation, and Horizontal Conflict: Case Study Reconstruction Aid Funds of The Bantul Earthquake
Authors: Isnadi Yuli , Asmarawati Handoyo
Published: July 2023

This investigation aims to show that the government’s policy without participation approach causes horizontal conflict in society. The case study is financial aid in reconstruction process for the earthquake’s victims in Bantul Regency, 2006-2007. This research collects secondary data, such as government’s documents, journals, books, news, and other relevant sources. Based on data analysis, we find that the absence of participation in policy making causes policy cannot accommodate the social context of the target group. As impact, community leaders and community members face a problematics situation that creates many problems during implementation. These problems, finally, lead the society into horizontal conflict. This finding might contribute in public policy and disaster management discourse, theoretical and practical, and build a path for the future research.
Performance Management Implementation in Local Government: Lessons from Recent International Literature
Authors: Prashina Mohangi  , Nyika Farai
Published: July 2023

There is an increased focus on employee performance management by employers, as a tool of improving efficiency of resource allocation and usage in local governments around the world. In an era of instant communication and widely available information, communities demand quality service delivery and they are quick to show their frustrations if their expectations are not met. Performance management has also been shown to increase local government accountability and transparency. The purpose of this article was to review and analyze relevant recent international academic literature to uncover themes and lessons in performance management implementation. A document review, was conducted to determine which studies to include in the literature survey by identifying (1) those published in an English peer reviewed journals on Google Scholar, and (2) those focused on performance management (PM) from an international/global perspective. The literature was classified into themes. In addition to classifying the articles, the paper summarizes the major findings of literature. This study finds that there are many challenges experienced in the implementation of performance management and there tends to be a mismatch of expectations of what performance management means to employees and employers. Also, Politicians dominate the administrative/ bureaucratic arm of local government, frustrating the purpose of performance management. This article also provides recommendations on how to improve the nature of performance management implementation.
Kedudukan Hukum Hasil Rapat Anggota Tahunan Sebagai Dasar Dalam Menjalankan Kegiatan Usaha Koperasi (Studi Pada Kantor Koperasi Karya Bahari Lombok Utara)
Authors: Mulyawan M
Published: July 2023

This study aims to determine the legal standing of the results of the Annual Member Meeting as a basis for carrying out cooperative business activities (study at the Karya Bahari Cooperative Office, North Lombok) ". This research is a kind of juridical-empirical research. The empirical study in this study was carried out through field studies by collecting primary data from respondents in the Karya Bahari Cooperative, North Lombok Regency. The juridical study in this research was carried out through a literature study by collecting secondary data in the form of laws and regulations relating to the protection of cooperative administrators. The results of the research show that as regulated in Law Number 25 of 1992 concerning Cooperatives in Article 22 Paragraph (1) which reads: "Members' Meetings are the highest authority in cooperatives" The law has regulated these interests. However, even though the law already exists, these companies often violate it to the point of causing harm to both the wider community and other companies. In Law No. 25 of 1992 concerning Cooperatives, and the Articles of Association of the Karya Bahari Cooperative "Navy" of North Lombok Regency, it does not specifically regulate legal protection for Cooperative Management. Thus, preventive legal protection is very significant for government actions based on freedom of action because with preventive legal protection, cooperative managers are encouraged to be careful in making decisions based on law. The handling of legal protection in general courts in Indonesia is included in the category of repressive legal protection
Analisis Dana Perlindungan Pemodal (Securities Investor Protection Fund) Sebagai Sarana Perlindungan Hukum Investor Di Pasar Modal
Authors: Ozora Hendrawan Ryan , Abubakar Lastuti , Harrieti Nun
Published: July 2023

This research aims to look at the Financial Services Authority (OJK) establishing an Investor Protection Fund (DPP) to protect investors in the capital market. This study discusses the scope of DPP protection and the effectiveness of DPP implementation in the capital market. The problem is focused on the DPP having a fairly narrow scope of protection, namely protection only for the loss of investor assets caused by the custodian, and only for SIPF members. The effectiveness of DPP implementation can be seen from two sides, namely as a compensation fund and as an investment fund. To approach the problem, references from the Law of the Agreement are used. The data were collected through literature and field studies, document study data collection tools, and interviews and were analyzed descriptively and qualitatively.This study concludes that the implementation of DPP can be divided into two types, namely DPP with its function as a compensation fund and DPP with its function as an investment fund, the implementation of DPP as an investment fund has been effective, as can be seen from its rapid development