bluuebunny/crossref_metadata_2025 huggingface dataset:
STRUCTURAL AND FUNCTIONAL DISORDERS OF THE THYROID GLAND IN DIFFERENT TYPES OF LARYNGEAL CANCER TREATMENT
Authors: Vorozhtsova I. N. , Mukhamedov M. R. , Cherkasova M. A. , Latypova V. N.
Published: June 2020

The thyroid gland is an important endocrine organ, which has a significant influence on human organism from the perinatal period and throughout the whole life, participating in the regulation of metabolism. The most common variant of thyroid dysfunction is hypothyroidism, which causes different disorders in various organs and systems, including psycho-emotional sphere. This can burden comorbidities and particularly malignant processes.Laryngeal cancer is the most common type of head and neck cancer. Despite the visual availability of this localization for diagnosis, more than 50% of cases stay timely unrecognized. Many cases are found out at stages III and IV, which requires expanded operations and causes traumatization because of disruption or loss of such important functions as breathing, swallowing, speech, causing long-term or permanent disability. This makes laryngeal cancer significant medical and social and economic problem.One of the leading treatments for cancer of the larynx is external beam radiotherapy. Thyroid gland gets into the radiation area and may take more than 50% of the total focal dose. The most common outcome of post-radiation inflammation is fibrosis of thyroid tissue due to lesions of the blood vessels and destruction of thyrocytes. It causes the development of hypothyroidism, which exacerbate stress caused by cancer and by aggressive antitumor therapy. Also, hypothyroidism adversely affects the patients’ condition during the postoperative period.Despite the fact that the diagnosis of hypothyroidism is pretty simple, and replacement therapy with L-thyroxine is cheap and available, many doctors don’t monitorthyroid function in cancer patients at all or don’t make all necessary tests.Thus, timely detection of hypothyroidism is extremely important during and after the treatment of laryngeal cancer. Early prescribing adequate treatment helps to reduce the incidence of complications.
DEVELOPMENT TRENDS OF SYSTEM OF TRAINING AND CONTINUOUS PROFESSIONAL DEVELOPMENT OF HEALTH PROFESSIONALS
Authors: Naigovzina N. B. , Konanykhina A. K. , Kochubei A. V. , Zimina Ye. V. , Navarkin M. V.
Published: June 2020

Implement approach of innovative education is development priorities of Russian system of training and continuous professional development of health professionals. Conception of innovative education is aligned with national policy, including statutory regulation, in the sphere of professional medical education.
THE PREDICTION OF HYPERTENSION IN MINERS
Authors: Mulerova T. A. , Ogarkov M. Yu. , Maksimov S. A. , Skripchenko A. Ye. , Artamonova G. V.
Published: June 2020

The relationships of risk factors with hypertension in workers of coal enterprises were studied. Based on the identified predictors developed risk prediction scale of this disease in miners.Surveyed 792 employees of the mine “Polosukhinskaya”. Along with a complete clinical, anthropometric and laboratory testing, conducted settlement criterion relative risk of developing hypertension.The most important factors determining the increased risk of disease in workers of coal enterprises were: increased body weight, age, waist circumference, and the index “waist/hip”, elevated levels of total cholesterol, triglycerides, low density lipoprotein cholesterol, atherogenic index. These signs and have the greatest prognostic factors that increase the risk of developing the disease.
THE VALIDATION OF THE RESULTS OF MICROARRAY STUDIES OF ASSOCIATION BETWEEN GENE POLYMORPHISMS AND THE FREQUENCY OF RADIATION EXPOSURE MARKERS
Authors: Khalyuzova M. V. , Litvyakov N. V. , Sazonov A. E. , Albakh Ye. N. , Isubakova D. S. , Karpov A. B. , Takhauov R. M.
Published: June 2020

The results from the selective validation research into the association between genetic polymorphisms and the frequency of cytogenetic abnormalities on a large independent sample are analyzed. These polymorphisms have been identified previously during own microarray studies. It has been shown an association with the frequency of dicentric and ring chromosomes induced by radiation exposure. The study was conducted among Siberian Group of Chemical Enterprises healthy employees (n = 573) exposed to professional irradiation in a dose range of 40–400 mSv. We have found that 5 SNP are confirmed to be associated with the frequency of dicentric and ring: INSR rs1051690 – insulin receptor gene; WRNrs2725349 – Werner syndrome gene, RecQ helicase-like; VCAM1 rs1041163 – vascular cell adhesion molecule 1 gene; PCTP rs2114443 – phosphatidylcholine transfer protein gene; TNKS rs7462102 – tankyrase gene; TRF1-interacting ankyrin-related ADP-ribose polymerase. IGF1 rs2373721 – insulin-like growth factor 1 gene has not confirmed to be associated with the frequency of dicentric and ring chromosomes.
METALLOTHIONEINS AS SENSORS AND CONTROLS EXCHANGE OF METALS IN THE CELLS
Authors: Kutyakov V. A. , Salmina A. V.
Published: June 2020

The basic information on the classification, structure, induction and degradation, functions of the protein family – metallothionein (MT), including CNS in health and disease are presented in this review. It was found that four major isoforms of metallothionein perform different biological roles, are localized in dif- ferent tissues. Induction of MT is a universal reaction to the impact of a variety of stress factors. In recent years, understanding of the role of metallothioneins in metal homeostasis in the tissues in normal and pathological conditions have changed significantly. Notes polyfunctionality metallothioneins (transport of metal ions, maintaining redox reactions, tread, signal, modulated and regulatory functions) and their im- pact on basic cellular functions such as proliferation, differentiation, programmed cell death. Further- more, a special role is shown MT in the pathogenesis of cardiovascular, neurodegenerative and neoplastic disorders.Currently, these molecules are increasingly considered as potential targets for therapy of a wide range of diseases and the development of targeted approaches to the regulation of expression of MT – one of the promising areas of pharmacology and toxicology. Stressed the safety of metallothioneins as therapeutic agents.
NUMERICAL SIMULATION OF ELECTRICAL IMPEDANCE TOMOGRAPHY PROBLEM AND STUDY OF APPROACH BASED ON FINITE VOLUME METHOD
Authors: Sherina Ye. S. , Starchenko A. V.
Published: June 2020

This research has been aimed to carry out a study of peculiarities that arise in a numerical simulation of the electrical impedance tomography (EIT) problem. Static EIT image reconstruction is sensitive to a measurement noise and approximation error. A special consideration has been given to reducing of the approximation error, which originates from numerical implementation drawbacks. This paper presents in detail two numerical approaches for solving EIT forward problem. The finite volume method (FVM) on unstructured triangular mesh is introduced. In order to compare this approach, the finite element (FEM) based forward solver was implemented, which has gained the most popularity among researchers. The calculated potential distribution with the assumed initial conductivity distribution has been compared to the analytical solution of a test Neumann boundary problem and to the results of problem simulation by means of ANSYS FLUENT commercial software. Two approaches to linearized EIT image reconstruction are discussed. Reconstruction of the conductivity distribution is an ill-posed problem, typically requiring a large amount of computation and resolved by minimization techniques. The objective function to be minimized is constructed of measured voltage and calculated boundary voltage on the electrodes. A classical modified Newton type iterative method and the stochastic differential evolution method are employed. A software package has been developed for the problem under investigation. Numerical tests were conducted on simulated data. The obtained results could be helpful to researches tackling the hardware and software issues for medical applications of EIT.
APPLYING OF GAS ANALYSIS IN DIAGNOSIS OF BRONCHOPULMONARY DISEASES
Authors: Bukreyeva Ye. B. , Bulanova A. A. , Kistenev Yu. V.
Published: June 2020

Bronchopulmonary system diseases are on the first place among the causes of people's death. Most of methods for lung diseases diagnosis are invasive or not suitable for children and patients with severe disease. One of the promising methods of clinical diagnosis and disease activity monitoring of bronchopulmonary system is analyzing of human breath. Directly exhaled breath or exhaled breath condensate are using for human breaths analyzing. Analysis of human breath can apply for diagnostic, long monitoring and evaluation of efficacy of the treatment bronchopulmonary diseases. Differential diagnostic between chronic obstructive lung disease (COPD) and bronchial asthma is complicated because they have differences in pathogenesis. Analysis of human breath allows to explore features of COPD and bronchial asthma and to improve differential diagnostic of these diseases. Human breaths analyzing can apply for diagnostic dangerous diseases, such as tuberculosis, lung cancer. The analysis of breath air by spectroscopy methods is new noninvasive way for diagnosis of bronchopulmonary diseases.
WAYS TO EVALUATE THE QUANTITY AND QUALITY OF KNOWLEDGE IN THE STUDY OF CLINICAL MEDICI
Authors: Tetenev F. F. , Bodrova T. N. , Karzilov A. I. , Tetenev K. F.
Published: June 2020

Analysis of the current literature showed that in publications, in our opinion, there is no master: a scientific analysis of the reasons behind the decline in the quality of knowledge of the doctor, as well as the scientific basis of modern pedagogical technologies introduced in the process of training future doctors to address this problem. Objective and subjective factors are having a negative effect on the quality of the doctor's knowledge. The generally accepted methods of assessing the quality of knowledge – testing and rating system – have their limitations. Testing reflects the level of knowledge about the thinking style of the originator of test tasks. Ranking system for assessing knowledge increasingly characterized by diligence in studying medicine. It is proposed to upgrade the quality of medical knowledge in the teaching of the theory of integration of diagnostics. Amount of knowledge to evaluate the content of educational narrative history of the disease. The quality of the knowledge to assess the content of professional clinical picture comment in the history of the disease.
DIFFERENTIAL DIAGNOSIS OF ROSACEA AND SKIN TUBERCULOSIS AS AN EXAMPLE OF A CLINICAL CASE
Authors: Aripova M. L. , Khardikova S. A.
Published: June 2020

In this paper for a clinical observation of a patient with rosacea, and patients with a flat form of lupus tuberculosis presented a differential clinical diagnosis of tuberculosis of the skin.
FEATURES OF THE INTESTINAL MICROBIOTA IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Ogorodova L. M. , Govorun V. M. , Fedosenko S. V. , Karnaushkina M. A. , Saltykova I. V. , Alekseyev D. G. , Kostrytikova Ye. S. , Tyakht A. V. , Popenko A. S.
Published: June 2020

The article summarizes the results of studies on the composition of microbial communities in stool samples of patients with chronic obstructive pulmonary disease (COPD) compared with healthy volunteers using genome-metagenomic sequencing. It is shown that the microbial community of the intestine in COPD patients is characterized as diverse taxonomic composition of metagenomes that the healthy volunteers microbiota. In this case, the normal composition of intestinal microbiota in patients with COPD is exposed to the qualitative and quantitative modifications. In contrast to healthy volunteers, the intestinal microbiota in patients with COPD is characterized by the presence of representatives of the Proteobacteria, as Citrobacter, Enterobacter, Eggerthella,Proteus, Salmonella, Anaerococcus, Clostridium difficile, Pseudomonas, as well as higher insemination fungus genusCandida (Candida dubliniensis and Candida albicans).
CLINICAL STATUS AND CHEMILUMINESCENT ACTIVITY OF NEUTROPHILS IN PATIENTS WITH ADVANCED PURULENT PERITONITIS IN THE DYNAMICS OF POSTOPERATIVE PERIOD
Authors: Savchenko A. A. , Cherdantsev D. V. , Pervova O. V. , Gvozdev I. I. , Borisov A. G. , Shapkina V. A.
Published: June 2020

The aim of this study was to evaluate the clinical condition and to study the chemiluminescent activity of granulocytes of patients with widespread purulent peritonitis in the dynamics of post-operative treatment. The severity of the patients was determined by the SAPS scale, the presence of systemic inflammatory response syndrome was assessed by the criteria of the ACCP/SCCM. Severity and prognosis of the disease was evaluated using the Mannheim peritonitis index and the index of abdominal cavity. The severity of multiple organ failure at admission to the hospital and in postoperative period dynamics were determined by the scale of the SOFA. The study of lucigenin- and luminal-dependent chemiluminescence of neutrophils in peritonitis were taken on admission to the hospital, and on the 7th, 14th and 24th day of the postoperative period. There were a variety of systemic complications (tertiary peritonitis, perforation of hollow organs, abscesses of the abdominal cavity and other) in patients with widespread purulent peritonitis 2nd severity in 96,2% of cases. The mortality rate among patients amounted to 22.2%. It was found in the study of neutrophils chemiluminescent activity that intensity of the “respiratory burst” in pre- and postoperative periods in patients with peritonitis is defined mainly by the synthesis level of secondary reactive oxygen species. The level of synthesis of superoxide radicals by neutrophils in a state of relative dormancy, increased by 14 days after the operation and is reduced to the reference level to the 21st day. In the preoperative period and before the end of the observation level of synthesis of secondary reactive oxygen species by neutrophils of patients with peritonitis was increased, but is on the background of the slow activation of enzymes, providing a “respiratory burst”. Trend towards normalization of neutrophils chemiluminescent activity in the blood of patients with peritonitis by the end of the observation period (24th day of the postoperative period).
ANALYSIS OF THE MODERN STATUS OF CLINICAL AND EXPERIMENTAL DATA ABOUT INTERACTION BETWEEN NERVOUS AND IMMUNE SYSTEMS
Authors: Nikiforova (Postnikova) T. A. , Peskov S. A. , Doronina O. B.
Published: June 2020

The article describes main aspects of development of the neuroimmunophysiology as a science and results of recent researches about interaction between nervous and immune systems on the example of acute cerebrovascular event. Particularities of post-stroke neuroimmunal dysfunction, main mechanisms of its realization and regulation, biological meaning were observed.
THE FOUNDATION AND DEVELOPMENT OF THE TOMSK SCHOOL PSYCHOLOGISTS (TO 125TH ANNIVERSARY OF THE OPENING OF THE DEPARTMENT OF PHYSIOLOGY)
Authors: Medvedev M. A. , Studnitskiy V. B. , Antonov O. I. , Skvortsov A. V. , Klimenko I. V. , Baikov A. N.
Published: June 2020

The history and development of the Department of Physiology of Tomsk State University (now the Department of Normal Physiology, Siberian State Medical University) and the main results and continuity of physiological functions of the digestive system doctrine has been presented.
DNMT3A GENE POINT MUTATIONS DETECTION IN ACUTE MYELOID LEUKEMIA PATIENTS USING SEQUENCING TECHNIQUE
Authors: Vinogradov A. V. , Rezaykin A. V. , Sergeev A. G.
Published: June 2020

Aim: to estimate the frequency of DNMT3A gene exons 18–26 point mutations in acute myeloid leukemia (AML) patients (pts) using target automatic sequencing technique.Material and Methods. Bone marrow and peripheral blood samples were obtained from 34 AML pts aged 21 to 64, who were treated in Sverdlovsk Regional Hematological Centre (Ekaterinburg) during the period 2012–2014. Distribution of the pts according to FAB-classification was as follows: AML M0 – 3, M1 – 1, M2 – 12, M3 – 3, M4 – 10, M5 – 2, M6 – 1, M7 – 1, blastic plasmacytoid dendritic cell neoplasm – 1. Total RNA was extracted from leukemic cells and subjected to reverse transcription. DNMT3A gene exons 18–26 were amplified by PCR. Detection of mutations in DNMT3A gene was performed by direct sequencing. Sequencing was realized using an automatic genetic analyzer ABI Prism 310.Results. The average frequency of functionally significant point mutations in DNMT3A gene exons 18– 26 among the treated AML pts was 5.9%. They were detected in morphological subgroups M2 and M4(according to WHO classification). The average frequency of DNMT3A gene exons 18–26 point mutations among the AML M2 and M4 pts without chromosomal aberrations and TP53 gene point mutations was 14.3%. In both cases there were samples in which DNMT3A gene mutations were accompanied by molecular lesions of NPM1, KRAS and WT1 genes. AML pts with DNMT3A gene exons 18–26 point mutations characterized by poor response to standard chemotherapeutic regimens and unfavorable prognosis.
EFFECT OF IMMUNE CELLS ON THE BEHAVIORAL ACTIVITY LEVEL OF MICE (СВАхC57BI/6)F1 DURING ONTOGENESIS
Authors: Anikeeva O. S. , Abramova T. Ya. , Kozlov V. A.
Published: June 2020

The features of forming of the orientation and exploratory behavior level (OEB) was established on sexually immature animals – mice (CBAxC57/Bl)F1, which underwent triple transplantation of splenocytes from adult syngeneic animals with a certain level of OEB during ontogenesis. Obtained data testifies an increase the part of passive animals in recipients group receiving splenocytes from low-level in behavior donors and an increase the part of animals with average level of OEB in recipients group receiving cells from donors with high OEB level and immature control group. The associations of recipients behavioral activity level with structural and functional features of donor cells was revealed: a relative increase in the OEB level under splenocytes transfer from donors with activated monocyte-macrophage link of immune system and a supression of OEB – from donors with activated T-cells.
COMPARATIVE ANALISYS OF COLD PLASMA COAGULATION AND SUTURING EFFECTS ON LIVER STRUCTURE IN THE EARLY PERIOD AFTER ATYPICAL RESECTION
Authors: Semichev Ye. V. , Baikov A. N. , Bushlanov P. S. , Gereng Ye. A. , Dambayev G. Ts.
Published: June 2020

The research was performed on 45 laboratory rats to make a comparative analysis of morphofunctional changes of rats' liver in early period after resection of left lobe and hemostasis by suturing and cold plasma. There were 3 experimental groups: 5 intact animals (control group) and 5 animals in each group after liver resection and suturing and liver resection and cold plasma coagulation. Material for research was taken on the 3rd, 7th, 14th, 30th day after surgery. Surgery is resection of liver left lobe, suturing or cold plasma coagulation. The biochemical control blood (glucose, ALT, AST, thymol test, total bilirubin, direct, alkaline phosphatase, total protein, urea, α-amylase, CRP, fibrinogen, aPTT, PTT, INR), morphological study of rat liver were performed. Analysis of biochemical markers reveals, that such indices as AST, α-amylase, alkaline phosphatase, fibrinogen, thymol test are increased in early period in experimental groups relatively the control group. A slight increase in the level of α-amylase is remained on the 30th day, this indicator in plasma group was less than indicator in suturing group. Other indices are normal. Analysis of morphological markers reveals, that such indices as specific volume of hepatocytes with signs of degeneration, the number of cells with necrotic changes in 1 mm2, infiltrate density in 1 mm2 and the specific volume of the connective tissue are increased, and then are gradually reduced to 30 days. Specific volume of binucleated hepatocytes in early period is reduced, and by the 30th day is increased. Indicators of liver damage in plasma group were statistically less than indicators in suturing group at all test points. It was found that pathological effects caused by the action of cold plasma were considerably lower than the effects produced by the suturing.
EFFECT OF INTRAOPERATIVE USE OF ULTRALOW TEMPERATURES ON THE COAGULATION HEMOSTASIS STATE AFTER HEPATIC RESECTION, DEPENDING ON THE FUNCTIONAL STATUS OF LIVER
Authors: Pchelintseva Ye. V. , Urazova O. I. , Lyzko I. A. , Al'perovich B. I. , Merzlikin N. V. , Novitsky V. V. , Baikov A. N.
Published: June 2020

The work has evaluated the impact of intraoperative cryotherapy on the coagulation indicators and the risk of hemorrhagic complications development after liver resection, depending on the original (preoperative) functional state of the organ and the resection method. 24 patients with liver lesions, aged 20 –55, have been operated; of them 9 patients had liver disorders prior to the surgery and 15 patients had no disorders. Half of the patients have undergone liver resection with cryotherapy, the remaining part of the patients have been exposed to conventional resection. The material for the research was venous plasma. According to the research findings, the post-operative dynamics of the coagulation indicators in the patients with liver lesions proves the advantage of using cryotherapy for minimizing the risk of hemorrhagic complications emergence. Thus, a tendency towards normalization of factors V, XI and XII content in blood plasma is more prominent after cryoresection of the liver, than after the conventional resection method (without cryotherapy). The international normalized ratio (INR) in the post-operative period exceeds the norm, regardless of the resection method and the functional state of the liver prior to the surgery. However, among the patients who had original liver disorder, INR is more than 2.0 before the surgery, whereas after the operation, despite the decrease, it remains above 1.4, which indicates significant hypocoagulation and high risk of hemorrhagic complications following the deficiency of the extrinsic coagulation pathway. Activated partial thromboplastin time after the surgery goes down, however, like before the surgery, it remains within the range of the commonly accepted reference values, regardless of the functional liver state and the resection method.
LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 IN CARDIOVASCULAR RISK STRATIFICATION AFTER CORONARY ANGIOPLASTY IN PATIENTS WITH TYPE 2 DIABETES: WHICH DECISION RULE THRESHOLD TO CHOOSE?
Authors: Teplyakov A. T. , Kuznetsova A. V. , Protopopova N. V. , Andriyanova A. V. , Suslova T. E. , Nasanova O. N. , Kalyuzhin V. V.
Published: June 2020

The research objective is to determine the posterior probability of adverse cardiovascular events after elective coronary intervention in patients with ischemic heart disease (IHD) associated with type 2 diabetes, at high level of lipoprotein-associated phospholipase A2 (Lp-PLA2) in blood serum, as well as to find out the optimal separation point value for this predictor, which increase allows to identify high risk with accuracy.Material and methods. The 12-month cohort observational study included 60 patients (78% of men and 22% of women) with IHD associated with type 2 diabetes, aged 48–78. At the beginning of the study, along with conventional diagnostic techniques typical of a specialized cardiology clinic, the state of carbohydrate and lipid metabolism was analyzed and the proinflammatory status was evaluated (including assessment of Lp-PLA2 concentration by ELISA). At the end of the study distant results of treatment were assessed. The following events were taken into account: death of cardiovascular events, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization (surgical, endovascular) due to restricture formation of a primary implanted stent or stricture formation of native coronary arteries, angina pectoris relapses.Results and discussion. The link between adverse cardiovascular events after elective percutaneous coronary intervention in patients with IHD type 2 diabetes-associated and high concentration of Lp-PLA2 in blood serum has been identified. Variation of the decision rule threshold on the performance curve has allowed to take Lp-PLA2 concentration of 983 ng/ml as a separation point. Accuracy of twoclass classification (determination of the posterior probability of adverse cardiovascular events) after identifying such separation point was characterized by 80% sensitivity and 100% specificity.Conclusion. The increase in the Lp-PLA2 concentration in blood serum (>983 ng/ml) may be considered as a predictor of adverse cardiovascular events after elective percutaneous coronary intervention in patients with IHD associated with type 2 diabetes.
TO THE QUESTION OF DIAGNOSTIC CRITERIA PERFECTION IN VIEW CIRCANNUAL VARIATION OF ORGANISM FUNCTIONING ADAPTIVE SYSTEMS IN CONDITIONS OF WESTERN SIBERIA
Authors: Barabash L. V. , Levitsky Ye. F. , Kremeno S. V.
Published: June 2020

Purpose of the research was studying circannual variation of parameters of hormonal regulation, lipids, oxidative systems of an organism of healthy men and women in conditions of Western Siberia.Monthly, within five years (2005–2009) on conditions of the voluntary informed consent 580 healthy donors (370 men and 210 women) in the age of from 25 up to 47 have been surveyed. In blood serum defined concentration of cortisol, insulin, thyroid hormones, concentration of cholesterol and other lipids, markers of stress and oxidative. Obtained data have been processed by adequate methods of the mathematical and statistical analysis.The analysis of results has shown that activity of functioning systems adaptation an of organism at all levels of the organization undergoes essential changes within a year. Revealed correlations are the certificate of cause and effect attitudes between the systems, providing adaptive mechanisms in constantly changing conditions of a living environment. The received results testify to an absolute must of revision of diagnostic criteria and expansions of concept of norm in view of circannual variation of functioning of physiological systems of an organism.
NEUROTROPIC AND DIURETIC ACTIVITY OF THICK EXTRACT OF THE BLOOD-RED HAWTHORN’S FRUITS
Authors: Kurkin V. A. , Kurkina A. V. , Zaitseva Ye. N. , Dubishchev A. V. , Pravdivtseva O. Ye. , Morozova T. V.
Published: June 2020

Blood-red hawthorn (Crataegi fructus) are a popular cardiotonic herbal materials, which widely used in medical practice in our country and abroad. In order to prevent diseases of the cardiovascular system is appropriate to prescribe herbal medicines, because they combine the breadth and softness of therapeutic action, along with the absence of a significant number of side effects and contraindications.The purpose was to study diuretic and antidepressant activity of thick fruit extract of blood-red hawthorn.Material and methods. Under laboratory conditions we obtained a thick extract of blood-red hawthorn fruits. This phytopharmaceutical was studied by us for any diuretic and antidepressant activity. Investiga- tions were carried out on white rats of both sexes weighing 200–220 g. Each experimental group consist- ed of ten animals. Study drug was administered intragastrically by stomach tube. Control in both cases served as purified water. For determination of diuretic activity, we used a thick extract of hawthorn fruits in a dose of 20 mg/kg against the background of the water load in the amount of 3% of body weight of the animal. Reference preparation was chosen dichlorthiazid 20 mg/kg. It was administered once. After ad- ministration the animals were placed in metabolic cages for urine collection for 24 hours. The study de- termined diuresis, natriuresis, kaliuresis, and kreatininuresis for 4 h and 24 h of the experiment. On the day of the experiment the animals of the control group was administered water load of 3%, and experi- enced – intragastrically drug in an identical amount. Animals were placed in a metabolic cage for a day. Collected 4 h and 24-h urine sample. Determined by renal excretion of water was recorded concentration of sodium and potassium by flame photometry in the fiery liquid analyzer PAG-1, creatinine – colorimet- ric method for photocolorimeter CFC-3. For determining antidepressant activity we used a thick hawthorn extract in a dose of 25 mg/kg of animal body weight. As a synthetic drug comparisons, we used amitriptilin 5 mg/g.Results. It was found that the thick extract of fruits of blood red hawthorn in a dose of 20 mg/kg for 24 hours increases the diuresis experiment, both by increasing the glomerular filtration rate and by lowering tubular reabsorption. For thick extract of fruits of hawthorn blood-red characteristic expression antide- pressant activity.Conclusion. The studied preparation of blood-red hawthorn’s fruits have properties to provide complex nephrotropic and neurotropic activity on the living organism.
THE COMPLEX OF INFORMATIVE IMMUNOLOGICAL PARAMETERS FOR BREAST CANCER OUTCOME PROGNOSIS
Authors: Stakheyeva M. N. , Serykh A. P. , Karas S. I. , Perina E. A.
Published: June 2020

Prognosis of disease outcome is important procedure for cancer patients treatment. The article presents the problem of elicitation of breast cancer prognosis criteria from immunological data as parameters complex.The aim is to identify necessary and sufficient amount of immunological parameters for accurate classification of breast cancer patients with various outcomes – clinical remission and hematogenous metastases.Material and methods. 36 immunological parameters were studied in 197 breast cancer patients T1–4N0–3M0. The “next neighbor” algorithm was used for identification of informative parameters. Detection of informative parameters complex was carried out by using ADD and DEL methods.Results. Two sets of informative immunological parameters were detected. The ADD method elicited parameters related to T-cell immunity, DEL – to humoral response.Conclusions. The complex of 17–19 immunological parameters characterizing different elements of immune system is necessary for accurate classification of breast cancer patients with different outcomes (presence/absence of hematogenous metastases).
THE ROLE OF MATRIX METALLOPROTEINASES AND THEIR TISSUE INHIBITORS IN THE DEVELOPMENT OF COMPLICATIONS OF KIDNEY DISEASE IN CHILDREN
Authors: Sukhanova G. A. , Terent’eva A. A. , Kuvshinov N. N.
Published: June 2020

The relevance of studying the role of matrix metalloproteinases (MMP) and tissue inhibitors (TIMP) in the pathology of the urinary system is determined, by the significant prevalence, prone to recurrent course of kidney disease in children. It is known that MMP-1 has pro-inflammatory action, MMP-2 and MMP-9 inhibits inflammation. TIMP-1 and TIMP-2 restricted cleavage of collagen. Disbalance between MMP and TIMP accompanied by the accumulation of extracellular matrix, increases the risk of chronic renal failure.The purpose of the study – to assess the role of MMP and TIMP involved in the processes of inflammation and resulting to renal dysfunction in glomerulonephritis and pyelonephritis in children.Material and methods. Surveyed of 15 children with a diagnosis of acute glomerulonephritis, 25 – chronic glomerulonephritis, 40 – chronic obstructive secondary pyelonephritis and 20 healthy children. In the group of patients with chronic glomerulonephritis renal function was impaired in 10 patients with chronic pyelonephritis – in 20 patients. The content of MMP-1, -2, -9 and TIMP-1, TIMP-2 in the serum of children was determined by ELISA.Results. It was found that in acute and chronic glomerulonephritis in children increases the content of MMP-1, MMP-2 is almost not changed, while the content of MMP-9 is reduced, which characterizes the presence of inflammation. In chronic pyelonephritis in a more pronounced reduction of MMP-9, antiinflammatory. The most significant changes were found in patients with impaired renal function. In all groups of patients experienced an increase in the level of TIMP-1 and TIMP-2.Conclusion. Thus, increasing the level of tissue inhibitors, elevated levels of MMP-1, decreased MMP-9, contributes to the progression of the disease and the development of inflammation and the accumulation of extracellular matrix proteins of interstitial kidney tissue, resulting in sclerotic and fibrotic changes.
THE ETHIOPATOGENESIS AND THE ANALYSIS OF AN ANTIBIOTIC TREATMENT OF A SMALL INTESTINE BACTERIAL OVERGROWTH SYNDROME
Authors: Martynov V. L. , Khairdinov A. Kh.
Published: June 2020

Article is attempt of the critical analysis of modern approaches to treatment of a small intestine bacterial overgrowth syndrome (SIBO). SIBO now is one of the major problems in gastroenterology. At the same time, the bacterial overgrowth is cause and consequence of many diseases of digestive system and extradigestive manifestations. Many researches testify to prevalence of SIBO in patients with digestive diseases. However, pathogenesis of a disease is studied insufficiently today. Nevertheless, the available data of scientific researches allow to belong to the offered ways of diagnostics and treatment critically.Data on physiology of microbiota of the digestive tract of the healthy person are provided in a review. Mechanisms of antimicrobic resistance of a microbiota of intestines are considered. Interrelations between an antibiotikassociated degeneration of normal flora and bacterial overgrowth are presented. The analysis of an antibiotiktherapi of SIBO indicates low efficiency and also possible ways became chronicle diseaseand frequent recurrence of an illness. The multiple-factors and complexity of pathogenesis of SIBO are leaded authors to a conclusion to use ethiopathogenesis approaches for solution of SIBO.
STUDY OF THE ACTIVITY EXTRACTS FROM SAUSSUREA CONTROVERSA AND FILIPENDULA ULMARIA IN EXPERIMENTAL OSTEOMYELITIS WITH THREE-PHASE SCINTIGRAPHY
Authors: Avdeeva Ye. Yu. , Zorkaltsev M. A. , Zavadovskaya V. D. , Slizovsky G. V. , Krasnov Ye. A. , Pekhenko V. G. , Stepanov M. Yu.
Published: June 2020

The activity of extracts from Saussurea controversa DC and Filipendula ulmaria (L.) Maxim studied on experimental osteomyelitis by means of 3-phase scintigraphy. The use of aqueous-ethanolic extracts of the aerial parts of plants helps to reduce the fixation of the radiopharmaceutical in the affected area and what characterizes their positive impact on the disease. These plants are promising objects for study of medicines the treatment of osteomyelitis.
INTERNATIONAL ASPECTS OF EDUCATION AND TRAINING IN TELEMEDICINE
Authors: Engelbrecht R. , Hasman A. , Mantas J. , Nicholson L.
Published: June 2020

Health care is based on patient data. The doctor, nurse or medical assistant are able by education, training, knowledge and experience to interpret patient data needed for diagnosis and treatment. Health care is dependent on a good education with respect to the management of data, information and knowledge. International activities point to ways to achieve a good level of education. These include criteria for curriculum development and accreditation, quality of information systems, further experience with a comprehensive training concept in England and the 10X10 approach in the United States.
ORGANIZATION OF MEDICAL CONTROL AND HEALTH CARE OF PERSONS, ENGAGED IN PHYSICAL CULTURE AND SPORT IN WESTERN SIBERIA IN 1920TH, PARTICIPATION OF V.S. PIRUSSKIY IN ITS FORMATION
Authors: Sarycheva T. V.
Published: June 2020

In the article a small amount of information about medical control in a country and Western Siberia in 1920th are presented. The participation of V.S. Pirusskiy in this organization is described. Basic directions of medical control are explained. The information on medical workers’ participation in the activity of committees of physical culture and organization of physical education is given.
THE EFFECT OF INTENSIVE GLYCEMIC CONTROL ON THE FACTORS DETERMINING PREDICTION COMPLICATIONS OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH TYPE 2 DIABETES
Authors: Fedotova A. I. , Vorozhtsova I. N. , Маksimov I. V. , Rebrova T. Yu. , Аfanasiev S. A. , Gusakova A. M. , Suslova T. E. , Маrkov V. A.
Published: June 2020

Objective. To determine predictors of complications of myocardial infarction (MI) in patients with type 2 diabetes (2TDM) and it’s value of intensive glycemic control during insulin infusion.Methods. The study included 112 patients with MI and 2TDM at first day of hospital admission with blood glucose level above 7.8 mmol/l. Prognosis of combined study endpoint included the death and ma-jor complications of MI for the hospital and long-term (6-month) stages. The statistical analysis was per-formed (Statistica 6.0 for Windows). The predictive value was assessed with ROC-curves analysis meth-od.Results. Intensive glycemic control with insulin infusion reduced the activity of lipid peroxidation and improve prediction of study endpoint. Predictors of adverse hospital prognosis of MI in association with type 2 diabetes were hyperglycemia on admission above 10 mmol/l, and increase of C-peptide. The in-crease of C-peptide in the 1st and 7th day, hs-CRP on day 1, diene conjugates on the 7th day and glucose level on admission above 8.9 mmol/l (patients without 2TDM) and 14.3 mmol/l (patients with 2TDM) had the 6-month predictive value.Conclusion. The strict achievement of the target level of glucose in acute MI improves it’s prognosis at the hospital and at a 6-month prospective study.
THE CLINICAL CASE OF STARK–KAESER TYPE SCAPULOPERONEAL SYNDROME
Authors: Valikova T. A. , Alifirova V. M. , Bychkova I. V. , Sabashkina K. Yu.
Published: June 2020

We present a rare case of Stark–Kaeser type scapuloperoneal syndrome type with mild weakness and hypotrophy in proximal limb, with rough paresis of feet, walking dysfunction and slowly-progressive course. The article briefly describes current views on the etiology and pathogenesis of this disease. The case is of interest to physicians of various specialties for the differential diagnosis of inherited neuromuscular disorders.
STRUCTURE OF THE ANAL CANAL AND ANAL SPHINCTER DOGS IN NORM AND AFTER PROCTECTOMY WITH BRINGING DOWN THE COLON
Authors: Bashirov S. R. , Trifonov M. N. , Gaidash A. A. , Tikhonov V. I.
Published: June 2020

With gistostereometry study the structure of the anal canal and anal sphincter dogs in norm and after proctectomy with bringing down the colon, forming neoanus and neosphinkter. The artificial sphincter is the inevitable process of smooth muscle atrophy can save at least half the volume of smooth muscle, similar to the number in the internal sphincter needed to restore function after holding involuntary proctectomy. Neoanus of mucous and submucosal colon relegated acquired typical smooth relief with the advent of the vertical pleats on the type of anal columns of Morgagni and with the perianal skin was closely associated with the subcutaneous portion of the external sphincter smooth muscle and an artificial sphincter. Thus, the experimental model of the internal sphincter and neoanus created by bringing down the mucous and the formation of smooth cuffs, very similar in quantitative and qualitative terms, the structure of the anal canal and anal sphincter dogs and can be used in clinical practice.
THE ROLE OF NEOPTERIN AS A POSSIBLE DIAGNOSTIC MARKER PREVALENCE EXTERNAL GENITAL ENDOMETRIOSIS
Authors: Novikova Ye. I. , Novikov D. G. , Indutny A. V.
Published: June 2020

Objective. Todetermine the diagnostic value of neopterin as a marker of dysfunction of peritoneal immune factors for estimating the severity of external genital endometriosis (EGE).

Material and methods. The concentration of neopterin in the peritoneal fluid (PF) and venous blood of 16 patients with EGE and 10 patients with benign ovarian cysts were evaluated.

Results. There wasn’t significant relationship between the concentration of the neopterin in the venous blood and clinical data. There weren't significant relationship between the concentration of the neopterin in the venous blood and clinical data. There were the significant correlation between the concentration of neopterin in the PF of patients with EGE and pain by the B'n'B scale (r = 0.545, p = 0.044) and pain by NRC scale of (r = 0.362 p = 0.203). There were correlation between the concentration of neopterin in the PF of patients with EGE and the severity of endometriosis by rAFS scale (r = 0.598, p = 0.051), and between the neopterin concentration in PF and adhesions (r = 0.487, p = 0.128).

Conclusion. Thus, it is possible to use the the neopterin concentrations in the PF of patients with EGE as a marker of disease severity and as a predictor of recurrence endometriosis.
Sosyal Bilgiler Eğitiminde Değerler Eğitimi Açısından Mehmet Akif ve Safahat
Authors: KÖÇ Ahmet , DEMİRKAYA Hilmi , ÜNAL Orhan
Published: June 2020

Değer; toplumun geneli tarafından doğru ve güzel olarak kabul edilen davranışlar olarak tanımlanabilir. Değerlerin aktarılması amacıyla gösterilen çabaları ise değerler eğitimi olarak tanımlamak mümkündür. Topluma ve kendisine faydalı, sorumluluk sahibi ve değerlerine sahip çıkan vatandaşlar yetiştirmek eğitim kurumlarının temel görevleri arasındadır. Bireyselleşmenin, ben merkezci düşünce yapısının ve uyuşturucu madde bağımlılığı, savaşlar gibi olumsuz durumların yaygınlaştığı günümüzde değerlerin ve değerler eğitiminin önemi daha da artmıştır. Toplum içerikli yapısı itibarıyla sosyal bilgiler dersinin amaçlarından birisi de değerlerin aktarılmasıdır. Bununla birlikte bu dersin öğretilmesinde üç temel yaklaşımdan birisi olan “vatandaşlık aktarımı olarak sosyal bilgiler öğretimi” toplumun değer ve inançlarının öğrencilere aktarılmasını amaç edinmektedir. Değerlerin aktarılmasında farklı yöntemler kullanılmaktadır. Bu yaklaşımlardan birisi de yaptıkları ve yaşantılarıyla topluma örnek olmuş kahramanların bu süreçte örnek olarak kullanılmasıdır. Bundan dolayı değerler eğitiminde tarihi şahsiyetlerin ve eserlerinin kullanılması değerlerin kazandırılmasına katkı sağlayacaktır. Bu araştırma da sosyal bilgiler dersinde değerler eğitimi açısından Mehmet Akif’in ve Safahat’ın incelenmesi amacıyla hazırlanmıştır. Araştırma nitel araştırma yöntemine uygun olarak durum çalışması deseninde kurgulanmıştır. Araştırmanın veri kaynağını Mehmet Akif Ersoy’un Safahat isimli eseri oluşturmaktadır. Verilerin toplanmasında doküman analizi yöntemi, verilerin analiz edilmesinde ise betimsel analiz tercih edilmiştir. Verilerin analiz edilmesi sonucunda Safahat’ta yer alan değerler dokuz balık altında sunulmuş ve doğrudan alıntılarla örneklendirilmiştir. Bu başlıklar ise şunlardır: Adalet, sorumluluk, bilimsellik, estetik, vatanseverlik, çalışkanlık, yardımlaşma, aile birliği, duyarlılık ve yardımseverlik. Araştırma sonuçlarına göre Akif’in Safahat’ı değerler eğitimi açısından oldukça zengin bir kaynaktır ve sosyal bilgiler dersi kapsamında kullanılması faydalı olacaktır.
La nutrition azotée influence l’ingestion chez la vache laitière
Authors: FAVERDIN P. , M’HAMED D. , RICO-GÓMEZ M. , VERITE R.
Published: June 2020

L’augmentation des teneurs en protéines des régimes est souvent associée à une augmentation de l’ingestion chez les vaches laitières, mais l’amplitude de ces réponses et les mécanismes sont encore mal connus. Cet article caractérise les effets des teneurs en azote et en protéines des régimes sur l’ingestion des aliments par les vaches laitières et discute les différentes hypothèses concernant les mécanismes. La fourniture en azote dégradable aux microbes du rumen et la disponibilité en protéines pour la synthèse du lait sont capables de stimuler l’ingestion. Ces effets peuvent être quantitativement importants et le plus souvent augmentent au cours du temps. Si le rôle de l’azote dégradable sur l’activité microbienne dans le rumen permet de bien comprendre l’augmentation des quantités ingérées, l’action des protéines sur la régulation de l’ingestion est moins facile à expliquer et pourrait être multifactorielle. Comme chez les monogastriques, les modifications possibles d’équilibre des acides aminés pourraient également modifier le contrôle de la prise alimentaire et expliquer des effets à court terme sur l’ingestion. Cependant, l’augmentation de l’effet des protéines sur l’ingestion au cours du temps milite plus pour une action indirecte, via la demande d’énergie ou la mobilisation des réserves par exemple, que pour une action directe des protéines sur le contrôle de la prise alimentaire. Ces hypothèses pourraient permettre d’intégrer les effets de l’alimentation protéique dans les modèles de prévision des quantités ingérées.
Besoins nutritionnels du lapereau et stratégies d’alimentation autour du sevrage
Authors: FORTUN-LAMOTHE L. , GIDENNE T.
Published: June 2020

Les besoins nutritionnels de la lapine allaitante sont antagonistes de ceux des lapereaux âgés de 20 à 42 jours. En effet, les besoins de la femelle allaitante sont élevés alors que la consommation d’un aliment de faible densité énergétique (pauvre en amidon et riche en fibres) pendant la période qui précède le sevrage améliorerait la viabilité des lapereaux après le sevrage. Plusieurs stratégies d’alimentation et d’élevage sont envisageables. Si le sevrage est réalisé entre 28 et 35 jours d’âge, une alimentation spécifique pour les jeunes, différente de celle de la mère, semble la solution la plus pertinente mais elle nécessite une modification du système de logement des animaux. A défaut, il convient de trouver un compromis entre les besoins nutritionnels de ces deux catégories d’animaux, par exemple une incorporation de matières grasses dans l’aliment permettrait d’accroître sa densité énergétique, sans réduire les apports de fibres. Cette solution privilégie la santé des jeunes au détriment de l’état corporel des femelles au sevrage. Le sevrage précoce (avant 26 jours d’âge) paraît aussi une alternative intéressante permettant de proposer aux lapereaux un aliment adapté à leurs besoins, et laissant plus de temps aux femelles pour reconstituer leurs réserves corporelles. Néanmoins, cette alternative nécessite des études complémentaires, tant pour préciser les besoins nutritionnels des lapereaux sevrés précocement que pour connaître les conséquences de cette pratique sur leur viabilité ultérieure.
Diagnostic et suivi de gestation chez la brebis : réalités et perspectives
Authors: EL AMIRI B. , KAREN A. , COGNIE Y. , SOUSA N.M. , HORNICK J.L. , SZENCI O. , BECKERS J.F.
Published: June 2020

Cet article décrit les différentes méthodes cliniques et de laboratoire utilisables pour établir le diagnostic de la gestation chez les ovins. Etant destinées à des applications dans les élevages, ces méthodes sont présentées en insistant sur la précocité de leur utilisation, sur les paramètres de sensibilité, de spécificité, d’exactitude de diagnostic positif, d’exactitude de diagnostic négatif et enfin sur leurs possibilités de dénombrement des fœtus. La méthode la plus précoce est le dosage de la progestérone. Elle fournit dès le 17e jour des valeurs élevées d’exactitude mais nécessite de connaître exactement le moment de la fécondation. Le dosage des protéines spécifiques ou associées à la gestation (PSPB, PAG) est également une méthode précoce, le diagnostic étant obtenu dès le 22e jour pour un dosage dans le sang et le 32e jour pour un dosage dans le lait. Il présente d’excellentes performances de sensibilité et de spécificité, mais ne permet pas de dénombrer les fœtus. Enfin, l’échographie mode-B, utilisable dès le 30e jour de gestation, donne, selon l’opérateur, de très bonnes à d’excellentes performances de sensibilité et de spécificité et permet de dénombrer les fœtus en temps réel.