bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Bacterial Co-Infection on Hospitalized Children with Human Rhinovirus and Human Metapneumovirus Infections: A Retrospective Analytical Cross-Sectional Study
Authors: Wan Qing , Li Ya-wei , Cheng Ying , Hu Hongbo
Published: October 2023

Background: Human rhinovirus (HRV) and human metapneumovirus (hMPV) are common viral causes of pediatric respiratory tract infections. Bacterial co-infections frequently complicate HRV and hMPV illnesses in children, but the interactions between viral and bacterial pathogens and their impacts on disease severity are not well understood. Objectives: The present research aimed to analyze and compare the clinical features of HRV and hMPV mono-infections in hospitalized children and to assess the impact of bacterial co-infection on the disease severity of HRV and hMPV infections. Methods: The present retrospective analytical cross-sectional study was conducted to compare the clinical features between HRV and hMPV mono-infections and HRV and hMPV with bacterial co-infections in hospitalized children aged 14 years or younger. Results: Between January and December 2022, we investigated 1,978 children hospitalized with HRV infection, of which 1,529 had HRV mono-infection and 1,117 hospitalized with hMPV infection, among whom 910 had hMPV mono-infection. Compared to HRV, hMPV mono-infection exhibited more pronounced symptoms of fever, cough, and rales in most age groups, while HRV showed more wheezing. Except in patients ≥ 6 years old, hMPV was more associated with pneumonia and longer hospitalizations. In contrast to HRV mono-infections, children with bacterial co-infections had a higher proportion of coughs (P < 0.001), pneumonia (P < 0.001), pediatric intensive care unit (PICU) admissions (P < 0.001), and longer hospitalizations (P = 0.003). Demographic characteristics, clinical presentation, diagnosis, and treatments showed no significant differences between patients with hMPV mono-infection and co-infection. Conclusions: Among hospitalized children, hMPV mono-infection resulted in more severe respiratory illnesses compared to HRV mono-infection. Bacterial co-infections exacerbated disease severity in HRV infections.
Pembesaran Ikan Lele Mutiara (Clarias gariepinus) dan Lele Sangkuriang (Clarias batrachus) di Balai Benih Ikan Lokal (BBI) Kota Pontianak, Provinsi Kalimantan Barat
Authors: Muslimah Muslimah , Ramadeni Yusri
Published: October 2023

Ikan lele  merupakan komoditas perikanan air tawar yang paling umum dibudidayakan yang hampir ada di seluruh wilayah Indonesia. Dikarenakan kemudahan dalam budidayanya dan harganya yang cukup terjangkau. Ikan lele memiliki tingkat pertumbuhan yang cepat dan dapat hidup diperairan dengan kondisi buruk. Lele mutiara dan lele sangkuriang merupakan strain ikan lele yang umum dibudidayakan. Sehingga tujuan dari penelitian ini adalah untuk mengamati budidaya pada pembesaran ikan lele mutiara dan sangkuriang. Kegiatan pembesaran pada penelitian ini diantaranya persiapan wadah dan air. Penebaran benih, pemberian pakan, pengelolaan kualitas air, manajemen pertumbuhan dan pemanenan. Pada penelitian ini, jumlah benih yang ditebar masing – masing 200 ekor untuk kedua jenis strain ikan ini. Jumlah pakan yang diberikan juga sama yaitu 5% dari total biomassa. Hasil dari penelitian menunjukan bahwa pertumbuhan bobot pada ikan lele mutiara yaitu  lebih tinggi dibanding lele sangkuriang. Bobot akhir lele mutiara sebesar 32,38 – 181,45 gr dan lele sangkuriang sebesar 47,9 – 111,38 gr. Dengan tingkat kelangsungan hidup mencapai 77 % pada lele mutiara dan 86% pada lele sangkuriang.
PERILAKU PROSOSIAL DALAM TRADISI KEMATIAN UMAT MUSLIM DI JAWA
Authors: Nurhasanah Rizki
Published: October 2023

This research is a descriptive qualitative research by describing in depth about the prosocial point of view in the death rituals of Muslims in Java. The results of this study are the prosocial behavior of the Javanese community in traditional rituals of death manifesting in feelings of empathy, providing moral support to the bereaved family, respecting the deceased by praying, and helping financially and physically when performing rituals such as selametan. So it can be seen that Muslim death rituals in Java contain prosocial behavior that must be preserved.
METODE KETELADANAN GURU TERHADAP KECERDASAN MURID
Authors: Abbas Ngatmin , Nuriana Mutia Azizah
Published: October 2023

The exemplary method is a method that from the past until now is considered the most interesting to study. The purpose of examining this exemplary method is for character building. Character education is part of the national education system and it is recognized that exemplary teachers will produce intelligent students. The exemplary method is the core of the teaching that was conveyed by the Prophet Muhammad, and from this exemplary he was able to bring about the best generations throughout his history.

The approach technique used in this study is (library research), namely research that seeks to focus on analyzing or interpreting written material based on its context. In this case the book Rasulullah the Teacher by Abdul Fattah Abu Ghuddah. The results of the study, Abdul Fattah Abu Ghuddah believes that the exemplary method has a stronger influence on intelligence, makes an impression on the soul, makes it easier to understand. It is more interesting to follow and emulate than the lecture and explanation methods. In determining a method Abdul Fattah Abu Ghuddah makes the Al-Qur'an and hadith as his philosophical foundation.

Keywords: Exemplary Method, Rasulullah, Intelligence
NURSE EDUCATION YESTERDAY, TODAY, TOMORROW
Authors: Stojanović Goran
Published: October 2023

The traditional orientation of the international organization of the Red Cross to support and raise nursing as a relevant factor in the achievement of goals and the transfer of work programs towards the protection and improvement of people's health, contributed to the Red Cross of Serbia developing its activity towards the increasingly complex training of health care personnel. The path was covered from lower schools for child care workers in republican centers, through a high school for nurses in Belgrade, to the eminent higher school for nurses - "College in Simina Street", the founder, together with the health service, planned to employ the first generations in key places in the teaching bases of the school and in schools for nurses, in order to ensure quality staff for raising the level of professional work and for inclusion in the processes of education and upbringing of generations of nurses to come. The Higher Medical School in Belgrade was founded in 1958 with two departments: the Department of Senior Nursing Technicians and the Department of Senior Sanitary Technicians. The education of senior nurses in Serbia until 1973 was carried out in two schools, namely the Higher School for Nurses of the Yugoslav Red Cross and the Higher Medical School in Belgrade. Already in 1971, the idea of integrating the Higher School for Nurses of the Yugoslav Red Cross with the Higher Medical School in Belgrade was initiated. Since 2007, the transformation of the school from higher to high has begun, and a study program of basic vocational studies for nurses has been created. This programme was accredited by the decision of the Ministry of Education of the Republic of Serbia dated April 30, 2007. The goal of the program is the higher education of nurses who should be qualified to work in the field of theoretical and practical nursing and to take on responsible tasks for the protection and improvement of health. The school's specialist study programs have a clearly defined role in the system of higher education of nurses, and they follow on from the basic professional studies. The new study program for Vocational master's nurse - clinical nursing lasts two school years and is realized through five modules within the framework of theoretical work, exercises, independent work of students, professional practice in health institutions, and the preparation of a master's thesis under the supervision of a mentor.
APPRENTICES TRAINING FOR INDEPENDENT WORK IN HEALTH CARE INSTITUTIONS
Authors: Kurtović Sofija
Published: October 2023

Background: The plan and program of apprenticeship for nurses, among other things, stipulate that the apprenticeship aims to introduce to the nurse the essence of healthcare, complement the knowledge acquired during schooling, and enable independent work after passing the professional exam. The apprenticeship program fundamentally complements the knowledge acquired in school institutions as well as the basics of the health care process. During the apprenticeship, the apprentices can determine and complement, and through practical work, train themselves for independent work with healthy and diseased people, family, and the social community, with the aim of achieving the highest possible level of health and independence in work. Aim: Perceiving of methodical approach of apprentice training for independent work in health care institutions, Methods: The observational indirect method was used in the research. The working method for data collection in this research was a survey. Two surveys were included in the research: for employed nurses and apprentices in health care institutions. The sample was 50 nurses and 50 apprentices, as random samples. In order to obtain realistic research results as much as possible, the respondents were from six different hospital institutions in Serbia. Results: Based on the goal and tasks of the research, the results of the survey showed that, on the national level, it is not specified who can train apprentices, the issue of organized training in healthcare institutions that train apprentices to do independent work, and the evaluation of acquired knowledge and apprentices’ skills. In healthcare institutions, the organized training of apprentices exists in a very small percentage. Apprenticeship training, at the largest percentage, is performed by nurses with many years of working experience. Mentors are not recognized as someone in charge of apprentices training for independent work. The satisfaction of apprentices with the training provided during the apprenticeship is not at an enviable level. Due to a lack of confidence in the quality of apprentices training, they undergo additional training after employment. Conclusion: Improving the process of apprenticeship training in the form of establishing standards, defining the conditions for apprentices training in health care institutions, evaluating training, defining the conditions for the health care institution itself that trains apprentices for independent work, recognizing the role of nurse mentors, and establishing the conditions for their mentoring are the basics for increasing the quality of the provided health care, faster independence in the work of newly employed nurses, and increased safety of patients in inpatient health care institutions.
Upaya Guru Pendidikan Agama Islam (PAI) dalam Membina Akhlak terhadap Sesama Siswa di SD Negeri 02 Pasaman
Authors: Lubis Muhammad Rifki Abrori , Murniyetti Murniyetti
Published: October 2023

This research is motivated by the lack of moral education provided by teachers in the educational unit, especially at Elementary Schools (SD). In shaping a child's moral character, referring to this background issue, the researcher was interested in conducting a more in-depth study on the Efforts of Islamic Religious Education (PAI) Teachers in Cultivating Morality Among Fellow Students at SD Negeri 02 Pasaman. This research aims to uncover the efforts of Islamic Religious Education (PAI) teachers in cultivating morality among fellow students, the obstacles faced by PAI teachers, and the efforts made by PAI teachers to overcome obstacles in fostering moral character among fellow students. Therefore, in conducting the research, the researcher chose the Field Research method. Hence, the appropriate method to use is qualitative. The data sources for this research consist of primary data, namely PAI teachers in SDN 02 Pasaman. While secondary data includes the curriculum, school archives, photographic documentation, and observation notes. The results of the research show that the efforts of Islamic Religious Education (PAI) teachers in cultivating morality among fellow students at SD Negeri 02 Pasaman are carried out through positive actions in their daily routines, such as setting a good example, spontaneous actions, and habituation in routine activities by PAI teachers at SD Negeri 02 Pasaman. This integration occurs in special programs involving weekly, monthly, and annual activities and is integrated into the learning process.
Proton Pump Inhibitors Modulate Gene Expression Profile in Esophageal Mucosa and Microbiome
Authors: Rajagopala Seesandra V. , Shilts Meghan H. , Correa Hernan , Das Suman R. , Choksi Yash A. , Jacobse Justin , Goettel Jeremy A. , Hiremath Girish
Published: October 2023

OBJECTIVE

Proton pump inhibitors (PPIs) are commonly used to manage children with upper gastrointestinal symptoms and without a formal diagnosis. We investigated the effect of PPIs on esophageal mucosal transcriptome and active microbiota in children with normal esophagi. Furthermore, we examined whether the differences in host esophageal mucosal gene expression were driven by an underlying esophageal epithelial cell type composition.

METHODS

Using metatranscriptomics, the host transcriptional and active microbial profiles were captured from 17 esophageal biopsy samples (PPI naïve [PPI−], n = 7; PPI exposed [PPI+], n = 10) collected from children without any endoscopic and histologic abnormalities in their esophagus (normal esophagus). Deconvolution computational analysis was performed with xCell to assess if the observed epithelial gene expression changes were related to the cell type composition in the esophageal samples.

RESULTS

The median (IQR) age of our cohort was 14 years (12–16) with female (63%) preponderance. Both groups were similar in terms of their demographics and clinical features. Compared with PPI−, the PPI+ had upregulation of 27 genes including the MUC genes. The cell type composition was similar between the PPI− and PPI+ groups. Prevotella sp and Streptococcus sp were abundant in PPI+ group.

CONCLUSIONS

In children with normal esophagus, PPI exposure can be associated with upregulation of esophageal mucosal homeostasis and epithelial cell function genes in a cell-type independent manner, and an altered esophageal microbiome. Additional studies are warranted to validate our findings and to investigate the causal effect of PPIs on the normal esophageal epithelium and microbial communities.
Evaluation of the Use of Naltrexone for Cholestatic Pruritus
Authors: Sweigart Andrew J. , Moore Astrela , Kendsersky Rebecca , Shah Amit A. , Zook Jessica
Published: October 2023

OBJECTIVE

Pruritus is a common symptom of liver disease, managed with various medications including opioid antagonists like naltrexone. Current literature surrounding the safety and efficacy of naltrexone for cholestatic pruritus is limited. Our objective was to describe naltrexone prescribing practices for cholestatic pruritus.

METHODS

We conducted a single-center, retrospective review of inpatients who received naltrexone for cholestatic pruritus. We gathered information on naltrexone dosing, frequency, dose adjustments, duration, elevations in liver function tests (LFTs), and use of additional antipruritic agents.

RESULTS

Thirty-nine patients and 122 dosing regimens were included for analysis. Most patients were male (56.4%) with a median age of 6.32 years (range, 0.63–18.89). The median weight-based doses of naltrexone were 1.45 mg/kg/dose (IQR, 0.84–2.81) and 1.86 mg/kg/day (IQR, 0.97–3.37). The median flat doses were 25 mg/dose (IQR, 12.25–50) and 50 mg/day (IQR, 25–50). The median number of additional antipruritic agents used before and after naltrexone initiation was 3 (IQR, 2–4) and 4 (IQR, 3–5), respectively (p < 0.001). The most common elevated LFTs were total bilirubin and alanine aminotransferase (ALT), occurring in 15% of patients.

CONCLUSIONS

Naltrexone dosing ranged between 1 and 2 mg/kg/dose once or twice daily, with larger weight-based doses prescribed in younger and lower-weight patients. Naltrexone was commonly added as a fourth-line agent and did not lead to discontinuation of other antipruritic therapies. Larger, prospective, controlled studies are needed to assess the safety and efficacy of naltrexone for cholestatic pruritus.
Comparing the Frequency of Culture-Positive Late Onset Sepsis With the Use of Ceftazidime Versus Cefotaxime in the NICU
Authors: Salter Jenna , Tran Van , Bastawrous David , Nuibe Andrew
Published: October 2023

OBJECTIVE

As broader spectrum antibiotics have been associated with adverse effects, our study evaluated whether the frequency of culture-positive late-onset sepsis (LOS) and multidrug resistant (MDR) infections were increased with the use of ceftazidime as compared with cefotaxime in the neonatal intensive care unit (NICU).

METHODS

This was a multihospital, retrospective chart review of patients who received at least 24 hours of ceftazidime or cefotaxime in the NICU between December 1, 2012 and August 31, 2021. Patients were excluded from analysis if they expired during the admission, had an incomplete history, positive cultures for an MDR infection prior to receiving either antibiotic, or received the alternate antibiotic within the same treatment course.

RESULTS

A total of 334 patients were included for analysis (ceftazidime, n = 147; cefotaxime, n = 187). The average birth weight was lower in the ceftazidime cohort compared with the cefotaxime cohort [1.46 kg (95% CI, 1.29–1.63 kg) versus 1.93 kg (95% CI, 1.75–2.11 kg), p = 0.0002] with a corresponding lower gestational age [28.9 weeks (95% CI, 28.0–29.9 weeks) versus 31.7 weeks (95% CI, 30.8–32.6 weeks), p = 0.0001]. Adjusting for baseline differences showed a protective effect for ceftazidime (OR = 0.32; 95% CI, 0.16–0.62; p = 0.0009). There was no statistically significant difference in the frequency of MDR infections between the cohorts (OR = 0.25; 95% CI, 0.053–1.14; p = 0.07), however this study was underpowered to detect the difference noted.

CONCLUSIONS

Ceftazidime appears to be a safe and effective alternative treatment option compared with cefotaxime in the NICU with no increase in the risk of culture-positive LOS or MDR infections.
Nutritional and functional values of microalgae (spirulina) naturally found in East Africa
Authors:   , Damessa Feven
Published: October 2023

Sub-Saharan Africa has a higher prevalence of undernutrition, which is the underlying cause of stunting and underweight problems in children. Undernutrition is generally caused by insufficient intake of nutrients; in Africa, it’s mainly due to over-reliance on plant-based staple diets which contain inadequate amount of essential nutrients. Spirulina is a naturally abundant microalgae with great nutritional values and could be utilized to fortify diets to enhance human health. Therefore, this study evaluated nutrient content, bioavailability and safety of locally found Spirulina products, focusing specifically in East Africa, to enable possible food-based strategic interventions aimed at improving human nutrition in the region. A field survey was conducted to identify local Spirulina producers in East Africa and obtain samples. A total of 54 mice were used in evaluating the nutrient bioavailability and safety in vivo. A randomized control trial research design was used to select and allocate mice into treatment groups. Randomly grouped mice were separately fed three diets: control (basal), test (15% Spirulina powder blended with 85% basal diet) and standard (basal diet supplemented with standard nutritional supplements). The test and standard diets had equivalent nutrient content to enable direct comparison of results. Nutrients content analyses showed that a 100 g analyzed Spirulina samples contains 70 g protein, 82 mg iron, 84.5 mg zinc, 1302 mg calcium, 628 mg phosphorous, 27 𝜇g vitamin A, 246.8 𝜇g vitamin B9, 3.99𝜇g vitamin B12, 1.92 mg QE/g total flavonoid and 2.99 mg GAE/g total phenolic. The nutrients bioavailability from the control diet was statistically lower than those of test and standard diets, whose results were comparable. After the feeding experiment, mice had no significant differences in their serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), cystatin C and troponin I concentrations, indicating that the studied concentrations of control, test and standard diets had no adverse effect on critical organs (liver, heart, or kidney) of the mice. These results indicate the safety of Spirulina and reinforce its importance in reducing undernutrition in humans.
Characterization of rhizobacteria and their formulation into biofertilizers for potato (solanum tuberosum l.) growth promotion in Tanzania
Authors:   , Aloo Becky
Published: October 2023

Rhizobacteria and their plant growth-promoting (PGP activities have widely been investigated as biofertilizers for many crops but rarely for the potato (Solanum tuberosum L.). In the present study, potato-grown soils from three agro-ecological zones in Tanzania were sampled, characterized, and a total of 145 rhizobacteria isolated from them. The isolates were screened in vitro for PGP activities like nutrients solubilization, nitrogen fixation, and phytohormones production, and 52 most-promising isolates were characterized and identified by 16S-rRNA sequencing. Their effects on pot-grown potatoes were evaluated against non-inoculated plants as controls. Klebsiella grimontii MPUS7, Serratia marcescens NGAS9, and Citrobacter freundii LUTT5 were selected based on their effects on pot-grown potatoes and formulated in different carrier materials as possible biofertilizers. Their shelf lives were determined as colony-forming units (CFU) under refrigerated (8 o C) and room conditions (25 ± 2 o C) for eight months and their effects on field-grown potatoes evaluated against recommended fertilizers and non-treated plants. Data analysis involved XLSTAT (2.3). Significant differences (p ≤ 0.05) were evident for the fertility-related properties of the sampled soils but not their nutrient contents. Though slightly acidic (pH < 6.5), non-saline (Electrical conductivity < 1 dS m -1 ), and greater proportions of silt + clay (average 46.85 ± 15.18%) than gravel and sand, the soils contained low nutrient levels which may not be ideal for potato production. The rhizobacteria significantly differed in their invitro PGP activities. Except for the number of days to emergence and flowering, rhizosphere soil pH, and salinity, potato growth-related parameters like tuber numbers, sizes, weights, and nutrient contents were enhanced by the rhizobacterial treatments in the screen house by up to 90%. The PM-1 formulation supported the maximum K. grimontii MPUS7 growth (5.3 log-CFU g -1 ) under refrigeration and C. freundii LUTT5 (4.1 log-CFU g -1 ) under refrigerated and room conditions but the highest K. grimontii MPUS7 population (3.7 log-CFU g -1 ) was realized in room-stored PM-4. The formulations also showed varied activities at enhancing potato growth and most had similar or greater effects on potato growth as the artificial fertilizers and can effectively be used to replace the use of synthetic fertilizers in potato production systems in Tanzania.
Evaluating performance of the improved hybrid passive and active mode solar dryers for processing Mangoes and Pineapples
Authors:   , Mohammed Ssemwanga
Published: October 2023

Farmers in East Africa have no access to modern processing technologies because they are costly and high-energy demanding to operate. As a result, they solely rely on the traditional open sun drying (OSD) method, which is ineffective and causes further loss of the produce. In response, a modified passive-mode hybrid solar dryer dubbed ‘Improved Solar Dryer (ISD)’ unit was developed. A conventional active mode hybrid solar dryer nicknamed a ‘Solar Photovoltaic and Electric (SPE)’ dryer was fabricated. In this study, the drying performance of the individual ISD and SPE dryers was evaluated and compared against that of the OSD method. The effect of the individual ISD and SPE dryers on the nutritional content and sensory quality of the solar-dried fruits, namely mangoes and pineapples, was also assessed. The fruits were dried using the ISD and SPE dryers, and OSD methods while following randomized complete block design experimental procedures. Results show that the drying performance of the ISD and SPE dryers was better than that of the OSD method. The SPE and ISD dryers took 10 and 18 hours to effectively dry the fruit products, respectively, as opposed to the 30 hours taken by the OSD method. The mean daily ambient temperature and relative humidity were 26.8oC and 26.7%, respectively. The mean drying air temperatures achieved by the ISD and SPE dryers were 27.7 and 40.3oC, respectively. The mean relative humidity achieved by the ISD and SPE dryers during the entire food drying process were 25.8 and 24.6%, respectively. The mean solar thermal energy recorded for the ISD dryer, SPE dryer, and OSD method were 4795, 5994, and 3595 W/m2 (Watts per square meter), respectively. The results suggest that the SPE dryer exhibited better drying performance than the ISD dryer. The results also confirm that the drying conditions attained by both the SPE and ISD dryers were superior to that of the OSD method. Results confirm an enhanced capacity and superior role of the ISD and SPE dryers in retaining both the sensory quality and nutritional content. Therefore, the ISD and SPE dryers are recommended for drying fruits.
Antimicrobial investigation of Tephrosia Vogelii hook.f from Hai District in Tanzania towards development of antifungal agents for topical application
Authors:   , Hanolo Stephano
Published: October 2023

Infectious diseases such as fungal diseases are the global health problem. Moreover, antimicrobial resistance to modern fungicides and antibiotics is even perplexing in the health settings. Such situation needs serious attention to search for alternative antimicrobial agents. Thus, this study aimed to investigate antimicrobial activity of Tephrosia vogelii Hook.f found in Tanzania and develop antifungal agents therefrom. The n-hexane, dichloromethane and methanolic extracts from leaves and roots of Tephrosia vogelii were evaluated for antimicrobial activity against Candida albicans (ATCC 90028), Cryptococcus neoformans (clinical isolate), Staphylococcus aureus (ATCC25923), Escherichia coli (ATCC29953), Klebsiella pneumoniae (ATCC 700603) and Salmonella typhi (NCTC 8385). A serial dilution method using the sterilized 96 wells of polystyrene microliter plates were used to determine the minimum inhibitory concentrations (MIC) of extracts. The in vivo toxicity of methanolic leaf and root extracts was evaluated using albino rats. Extracts doses of 600, 1200, 2000 and 5000 mg/kg body weight were evaluated for lethality test while doses of 600, 1200 and 2000 mg/kg body weight subjected for sub-acute toxicity test. Gas Chromatography-Mass Spectrometry (GC-MS) technique was employed to appraise phytochemical compounds present. Antifungal agent for topical application was formulated and evaluated through in vitro and in vivo test to establish its effectiveness. The study results revealed that n-hexane and dichloromethane extracts exhibited the lowest activity. Equally, methanolic root and leaf extracts exhibited high activity at MICs ranging from 0.625 - 5.0 mg/mL against assayed pathogens. Phytochemical screening of both methanolic leaf and root extracts revealed the presence of tannins, flavonoids, terpenes, fatty acids and saponins. The GC-MS analysis unveiled the presence of ten phytocompounds. Five compounds; demethylmunduserone sumatrol, munduserone, hexadecanoic acid and hexadecanoic acid, methyl ester are new and this is the first time to be reported from Tephrosia vogelii. Furthermore, toxicity evaluation revealed that methanolic leaf and root extracts of Tephrosia vogelii were not deleterious at highest dose of 5000 mg/kg body weight. Though there was no mortality recorded, histopathological examination revealed toxicity indices due to vacuolation and necrosis in hepatocytes under treatment of methanolic root extracts of dose 2000 mg/kg body weight. The herbal cream prototype (CBTV3) was formulated, and it exhibited antimicrobial activity through in vitro and in vivo tests. The development of herbal cream prototype from Tephrosia vogelii Hook.f is hereby reported for the first time.
การวิเคราะห์ค่าชดเชยด้านผลกระทบสิ่งแวดล้อมของศูนย์กระจายถ่านหิน
Authors:   , ธรรมมา อิทธิศักดิ์
Published: October 2023

ในการก่อสร้างและดำเนินการของโครงการศูนย์กระจายถ่านหินในประเทศไทยจะก่อให้เกิดผลกระทบต่อสิ่งแวดล้อม ดังนั้นจึงต้องมีรายงานผลกระทบสิ่งแวดล้อม (EIA) และต้องได้รับความเห็นชอบจากชุมชนโดยรอบด้วย ไม่เช่นนั้นจะไม่สามารถดำเนินโครงการได้ ในงานวิจัยนี้จึงมีวัตถุประสงค์เพื่อศึกษาหามูลค่า ค่าชดเชยที่เหมาะสมหรือเป็นธรรมระหว่างเจ้าของโครงการกับชุมชนโดยรอบ โดยใช้เทคนิคการเสวนา (Forum) ซึ่งจะใช้ข้อมูลจาก มูลค่าความเสียหาย (Damage Cost) และมูลค่าที่ชุมชนคาดหวัง (Social Cost)

มูลค่าความเสียหาย (Damage Cost) จากการศึกษาและทบทวนรายงานผลกระทบสิ่งแวดล้อม (EIA) พบว่าโครงการศูนย์กระจายถ่านหินจะก่อให้ผลกระทบ คือมลพิษทางอากาศ และมลพิษทางเสียง ดังนั้นในงานวิจัยนี้จะใช้เทคนิคทางการระบาดวิทยาเพื่อประเมินผลกระทบที่เกิดขึ้นจากฝุ่นขนาดเล็กกว่า 10 ไมครอน และใช้เทคนิคการวิเคราะห์ผู้มีส่วนได้ส่วนเสีย (Stakeholder Analysis) ร่วมกับเทคนิคการแปลงมูลค่า (Benefit Transfer Method) เพื่อหามูลค่าความเสียหายที่เกิดขึ้น สำหรับมูลค่าที่ชุมชนคาดหวัง (Social cost) หามาจากการใช้แบบสอบถามในการเก็บรวบรวมข้อมูล โดยแบบสอบถามดังกล่าวจะใช้เทคนิคการสมมติเหตุการณ์ (Contingent Valuation Method) เพื่อหามูลค่าความเต็มใจยอมรับค่าชดเชย (Willingness to Accept) แล้วนำข้อมูลที่ได้มาวิเคราะห์ปัจจัยที่มีอิทธิพลต่อมูลค่าความเต็มใจยอมรับค่าชดเชยด้วยการวิเคราะห์ถดถอยแบบพหุ (Multiple Regression Analysis) เพื่อสร้างแบบจำลองทางคณิตศาสตร์ (Mathematical Model) สำหรับประเมินมูลค่าที่ชุมชนคาดหวัง

จากผลการศึกษาพบว่า โครงการก่อให้เกิดผลกระทบด้านเสียง จากการขนส่งวัสดุในระยะก่อสร้าง และการฟุ้งระจายของฝุ่นในระยะดำเนินดำเนินการ พบว่ามีค่าความเสียหายที่เกิดขึ้น 157,251,324 บาทต่อปี และจากแบบสอบถาม จำนวน 400 ตัวอย่างพบว่าปัจจัยที่มีอิทธิพลต่อมูลค่าความเต็มใจยอมรับค่าชดเชย คือ ปัจจัยคะแนนผลกระทบสิ่งแวดล้อม, ระยะทาง, ความถี่ของการเกิดโรค และระยะเวลาที่พักอาศัย โดยมูลค่าที่ประชาชนคาดหวัง(Social Cost) ที่ได้จากการคำนวณคือ 203,318,921 บาทต่อปี เมื่อนำข้อมูลที่ได้ไปจัดเสวนา พบว่าค่าชดเชยมีมูลค่า 223,664,529 บาทต่อปี
การเปรียบเทียบวิธีลูกโซ่มาร์คอฟมอนติคาร์โลสำหรับการอนุมานแบบเบส์เมื่อมีเงื่อนไขบังคับเชิงอันดับ
Authors:   , อุทธโยธา ณภัชนันท์
Published: October 2023

งานวิจัยนี้นำเสนอวิธีการสุ่มตัวอย่างของลูกโซ่มาร์คอฟมอนติคาร์โล (Markov chain Monte Carlo: MCMC) แบบใหม่ที่เรียกว่า โพลาร์เมโทรโปลิสฮิตแอนด์รันแบบแกมมา (Gamma type Polar Metropolis Hit-and-Run: PMHR-G) ซึ่งพัฒนามาจากวิธีโพลาร์เมโทรโปลิสฮิตแอนด์รันแบบปกติ (Normal type Polar Metropolis Hit-and-Run: PMHR-N) เพื่อประมาณค่าพารามิเตอร์บนเงื่อนไขที่ตัวแปรมีการจัดเรียงอันดับอย่างสมบูรณ์ และเปรียบเทียบประสิทธิภาพของวิธีการสุ่มตัวอย่างแบบ PMHR-G ที่นำเสนอกับวิธีการสุ่มตัวอย่างแบบ PMHR-N และวิธี MCMC อื่นที่รู้จักกันดีอีก 2 วิธี ได้แก่ วิธีการสุ่มตัวอย่างแบบกิบส์ (Gibbs) และวิธีการสุ่มตัวอย่างแบบฮิตแอนด์รัน (Hit-and-Run: HR) การวัดประสิทธิภาพอาศัยค่าขอบเขตบนของความเชื่อมั่นแบบข้างเดียวของตัวประกอบอัตราส่วนที่ปรับลดแล้ว (corrected potential scale reduction factor: PSRF) ประกอบกับกราฟค่าเฉลี่ยสะสมของตัวแปรที่สนใจศึกษา ข้อมูลที่ใช้เป็นข้อมูลจำลอง โดยมีจำนวนมิติ 3 ระดับคือ 10, 50 และ 100 ค่าสัมประสิทธิ์สหสัมพันธ์ 4 ระดับคือ 0, 0.5, 0.75 และ 0.9 และมีเวกเตอร์ค่าเฉลี่ย 3 ลำดับคือ เวกเตอร์ศูนย์ เวกเตอร์ที่มีสมาชิกอยู่ในรูปของลำดับเพิ่ม ซึ่งมีค่าตั้งแต่ -1 ถึง 1 และเวกเตอร์ที่มีสมาชิกอยู่ในรูปของลำดับลด ซึ่งมีค่าตั้งแต่ 1 ถึง -1 จากการทดลองทั้งหมด 36 กรณี พบว่าจากเกณฑ์การวัดประสิทธิภาพทั้ง 2 เกณฑ์ โดยมี 25 กรณี (69.44%) ให้ผลสรุปตรงกัน สำหรับกรณีที่ผลสรุปตรงกันและสามารถวัดประสิทธิภาพได้ มีทั้งหมด 13 กรณี พบว่า 12 กรณี (92.31%) ที่การสุ่มตัวอย่างแบบ PMHR-G มีประสิทธิภาพสูงที่สุด และมีเพียง 1 กรณี (7.69%) เท่านั้นที่พบว่าการสุ่มตัวอย่างแบบ Gibbs มีประสิทธิภาพสูงที่สุด
The Role of Telemedicine Technology in Stroke Patient Care
Authors: Alexander Hartanto Williem
Published: October 2023

Technological advances in the health sector are one of the factors in meeting optimal health, especially in places that provide health services. The use of technology in helping health services is one of the uses of telemedicine technology in treating stroke patients. This writing aims to discover the role of telemedicine technology in the care of stroke patients. The research method used in this study is descriptive-analytical. The study was conducted to analyze selected literature from various sources, which will later become a new idea related to the role of telemedicine technology in the care of stroke patients. The results of this study show that Telemedicine is considered very important for handling and providing therapy to patients, which is undoubtedly supported by the correct diagnosis. Telemedicine with health interventions through the capabilities of information technology, either smartphones or other wireless networks, extensively provides benefits and opportunities for the world of health to have a good influence in improving the quality of life of patients with stroke.
Pelatihan Matematika Bagi Tim Lomba Cepat Tepat (LCT) SMP Negeri 9 Kota Kendari Dalam Rangka Persiapan Mengikuti LCT Tingkat SMP/MTs se-Sulawesi Tenggara di FMIPA UHO
Authors: Somayasa Wayan , Jufra Jufra , Sani Asrul , Djafar Muhammad Kabil , Budiman Herdi , Muhtar Norma
Published: October 2023

Title of this community service is “Mathematics Training for the Fast Precise Competition (LCT) Team at a SMP Negeri 9 Kendari in Preparation for Taking Part in LCT at SMP/MTs Level Throughout Southeast Sulawesi at FMIPA UHO”. Implemented with the aim of increasing the capacity of mathematics teachers at SMP Negeri 9 Kendari and improving the abilities of the LCT Team at SMP Negeri 9 Kendari in preparation for taking part in LCT level throughout Southeast Sulawesi at FMIPA UHO. The results of this community service activity are increased capacity of mathematics teachears and an increase in knowledge and abilities of the LCT Team at SMP Negeri 9 Kendari in the mathematics. The LCT Team SMP Negeri 9 is ready to take part in LCT Mathematics.
Exact Solution of the Position-Dependent Mass Schrödinger Equation with the Completely Positive Oscillator-Shaped Quantum Well Potential
Authors:   Institute of Physics, State Agency for Science and Higher Education, JAFAROV E.I. , NAGIYEV S.M. ,   Institute of Physics, State Agency for Science and Higher Education
Published: October 2023

"Two exactly-solvable confined models of the completely positive oscillator-shaped quantum well are proposed. Exact solutions of the position-dependent mass Schrodinger equation corresponding to the proposed quantum well potentials are ¨ presented. It is shown that the discrete energy spectrum expressions of both models depend on certain positive confinement parameters. The spectrum exhibits positive equidistant behavior for the model confined only with one infinitely high wall and nonequidistant behavior for the model confined with the infinitely high wall from both sides. Wavefunctions of the stationary states of the models under construction are expressed through the Laguerre and Jacobi polynomials. In general, the Jacobi polynomials appearing in wavefunctions depend on parameters a and b, but the Laguerre polynomials depend only on the parameter a. Some limits and special cases of the constructed models are discussed."
Constructing Families of Solutions to an Integrable Time-Dependent Shallow Water Wave Equation in (1+1)-Dimensions
Authors:   School of Physics and Electronic Engineering, Shanxi University, KANG ZHOU-ZHENG , YANG RONG-CAO ,   School of Physics and Electronic Engineering, Shanxi University
Published: October 2023

In this paper, an integrable shallow water wave equation with timedependent coefficients in (1+1)-dimensions is taken into account. Through employing the generalized three-wave methods, a series of (double) solitary wave solutions and periodic (solitary) wave solutions to the considered equation are presented with the aid of symbolic calculation. Furthermore, by specifying relevant functions and parameters, the localized structures of some resulting solutions are displayed via some figures. These results enrich the diversity of nonlinear waves in physics.
Minimizing Radioactive Waste through Chemical Decontamination Techniques
Authors:   Horia-Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), GURAU D. , IORGA I. ,   Horia-Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), ZICMAN L. ,   Horia-Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), DONE L. ,   Horia-Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), NEACSU E. ,   Horia-Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH)
Published: October 2023

"Effective decontamination is crucial for managing radioactive waste, and it is important to find optimal practices that consider factors such as ease of use, reduction in secondary waste, and hazardous nature of the material. The study evaluates a chemical decontamination gel effectiveness in removing radioactive materials from commonly used materials at IFIN-HH. Artificially contaminated materials were tested, and the gel decontamination factor was evaluated. The gel has advantages such as easy application, high decontamination factor, and minimal contamination of radioactive materials, making it a promising method for efficient and safe management of radioactive waste. "
Scanning QR codes in R
Authors: Ooms Jeroen
Published: October 2023

The latest version of the opencv R package can detect and decode QR codes!# Install latest opencvinstall.packages("opencv", repos = "https://ropensci.r-universe.dev") There are two ways of using this: the ocv_qr_detect function tries to find the QR in an image file.
Incidencia de la Gestión pública en la calidad de servicio y accesibilidad de gestantes añosas de un centro materno en Chiclayo. Perú
Authors: Ucañay Dávila Lourdes Evelia , Veramendi Vernazza Rossana Teresa
Published: October 2023

En la medida que las autoridades y funcionarios del sector salud desarrollen una gestión pública basada en la identificación de intervenciones efectivas, para establecer metas y estrategias de mejora de coberturas y evaluar las que impiden que las intervenciones y servicios lleguen a los grupos más vulnerables, como son las gestantes añosas, será más viable fortalecer un sistema de salud efectivo, equitativo y eficiente con miras al mejoramiento de los procesos de las instituciones de salud como los centros maternos. Por esta preocupación, se realizó esta investigación con la finalidad de dar a conocer si la gestión pública incide en la calidad de servicio y la accesibilidad en gestantes añosas, se pretende que los resultados sean útiles para la toma de decisiones y futuras acciones. Es así que este estudio es realizado en Chiclayo el año 2023, de enfoque cuantitativo, transversal y correlacional-causal, con una muestra de 250 gestantes de 36 a 40 años, de muestreo no probabilístico y por conveniencia. El levantamiento de los datos fue realizado con 3 cuestionarios: Gestión pública, calidad de servicio y accesibilidad, los cuales fueron validados por juicio de expertos y se halló su confiabilidad con una prueba piloto a 30 embarazadas añosas. El análisis inferencial fue con el análisis multivariado de correlación canónica no lineal y la regresión logística ordinal. Dados los resultados, se evidenció que con un ajuste máximo del 56.4% se afirma que existe incidencia significativa de la gestión pública en la calidad de servicio y accesibilidad a gestantes añosas de un centro materno en Chiclayo. Esto indica que existe dependencia de la calidad de servicio y accesibilidad frente a la gestión pública.
Türkiye'de Turizm Sektörünün Ekonomik Büyümeye Katkısı: Cumhuriyetten Günümüze
Authors: EŞSİZ Fatma Pınar
Published: October 2023

Turizm bir ülke ekonomisi için gelir ve istihdam yaratıcı bir sektör olarak görülmektedir. İstihdama katkı sağladığı alanlar yalnızca turizm sektörüyle sınırlı kalmamakta, tarım, iletişim, sağlık ve eğitim sektörü gibi alanları da kapsamaktadır. Ayrıca ileri-geri bağlantıları olan bir sektördür. Bir yandan ülkenin altyapısının gelişmesini sağlarken, diğer yandan yabancı ziyaretçilerle vatandaşlar arasında kültürel bir etkileşim fırsatını da doğurmaktadır. Bahsedilen özellikleriyle turizm sektörü literatürde ekonomik büyümeye katkı sağlayacak bir alternatif olarak düşünülmektedir. Bu çalışmanın konusu Türkiye ekonomisinin kuruluşundan günümüze kadar geçen süre zarfında turizm sektörünün tarihsel gelişimi ve sektörün ekonomik büyümeye olan katkısını araştırmaktır. Bu amaçla ulaşılabilen en geniş veri setini kapsayacak şekilde 1963-2022 dönemi için Türkiye İstatistik Kurumu (TÜİK) ve Dünya Bankası resmi sitelerinden elde edilen veriler kullanılarak ARDL analizi aracılığıyla sektörün ekonomik büyümeyle ilişkisi ortaya konmaya çalışılmıştır. Yapılan analizler sonucunda literatürü destekleyecek şekilde uzun dönemde ekonomik büyüme ve turizm gelirleri arasında pozitif ve istatistiki olarak anlamlı bir ilişki tespit edilmiştir.
Rex et Regnum: Király és királyság, hasonlóságok és különbségek I. Károly kasztíliai (1516–1556) és I. Ferdinánd magyarországi (1526–1564) uralma között a közjog tükrében
Authors: Liktor Zoltán Attila
Published: October 2023

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How to Preserve Local Autonomy? Special economic zones through the lens of constitutional requirements
Authors: Siket Judit
Published: October 2023

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Az emberi jogok lehetnek-e univerzálisak? A kulturális relativizmus és az univerzalizmus konfliktusa az emberi jogok filozófiai és gyakorlati megközelítéseiben
Authors: Takács Izolda
Published: October 2023

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The History of Chinese Copyright and Legal Orientalism
Authors: Xiao Baiyang
Published: October 2023

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Magyarország és Románia helyi önkormányzati rendszerének összehasonlítható elemzése
Authors: Veilandics Eszter
Published: October 2023

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AUDIT OF INNOVATIONS
Authors: Ahmadov Goshgar Ilkin
Published: October 2023

The purpose of the research – innovations are a direction for the development of the economy, based on this, an audit of innovatives phenomena is also required in order to check whether this innovation is really a novelty or plagiarism.

The methodology of the research – during the study, such methods as analysis, comparison, abstraction were used.

The practical importance of the research – at the moment, this type of audit, in principle, is very poorly developed not only in Azerbaijan, but also in the international market, and the introduction of a methodology for conducting this audit is a very important step towards a new era.

The results of the research – this work is of interest to specialists in the field of audit, accounting and financial accounting, as well as to scientists engaged in research in these areas.

The originality and scientific novelty of the research – the novelty of this work is to give a lever to the introduction of innovation audit in Azerbaijan, as well as to give a detailed explanation of the methodology for its implementation. Also, innovation processes will be described here to increase the interest of society in this, thereby contributing to an increase in the country's economic growth.
ECONOMIC IMPORTANCE OF INNOVATIVE DEVELOPMENT OF AGRICULTURE IN AZERBAIJAN
Authors: Hasanzade Akram Niyazi
Published: October 2023

The purpose of the research - innovative activity in agriculture is the creation or
improvement of new agricultural products, and the provision of consistent measures for the
development of technologies and management systems based on the use of scientific research
works or production experience. Differentiation of innovative activity in Azerbaijani
agriculture by its characteristics requires conducting new research works.
The methodology of the research - economic methods such as analysis, comparison,
observation, and statistical analysis were used in the research work.
The practical importance of the research - the proposals and recommendations given
as a result of the analyses carried out in the article can be used to ensure and plan the
development of farms' own production based on innovative technologies, and to prepare
innovation projects in agriculture.
The results of the research - the processes described in the article can help increase the
competitiveness of agriculture and investment attractiveness. This is the reason for the
relevance of research in this field.
The originality and scientific novelty of the research - ensuring the efficiency of
industrial development is one of the strategically important areas of the national economy,
and the insurance level of the food security of the state depends on the pace of development of
the application of innovative technologies in agriculture. In the course of the research, the
factors hindering the innovative development of the agricultural sector and the main features
and elements of the innovation process were determined.
La “niña santa”: Laura Vicuña en las hagiografías y biografías históricas (1911-1990)
Authors: Nicoletti Maria Andrea
Published: October 2023

La santidad es una construcción histórica que nos permite indagar desde textos hagiográficos y biográficos, que nutren el proceso de canonización de la Iglesia Católica, al entorno social del santo/a, en este caso de la beata Laura del Carmen Vicuña (1891-1904). Esta niña fue alumna de las Hijas de María Auxiliadora, congregación de religiosas fundada por Don Bosco y Madre Mazzarello en Italia, en 1872. Para ello hemos seleccionado y clasificado un conjunto de hagiografías y biografías cómo fuentes históricas, para analizarlas desde la hermenéutica de esta disciplina. El objetivo es observar como la sociedad otorga a uno de sus miembros rasgos de santidad para llevarla a los altares. El primer conjunto biográfico corresponde a las primeras hagiografías escritas entre 1911 y 1945 por el salesiano Augusto Crestanello y las Hijas de María Auxiliadora M. Puttini (María Magdalena Moretti) y Alba Nembri. Estas hagiografías construyen la santidad de Laura en función de su presentación a la Causa de los Santos en el Vaticano para su beatificación. Las biografías del segundo periodo, entre 1958 y 1990, contienen debates que buscar comprobar hechos históricos y encontrar el rostro “verdadero” de Laura. Los salesianos Raúl Entraigas, Luigi Càstano y Ciro Brugna enfatizan el contexto histórico y el de las misiones salesianas. Sin dejar la sección hagiográfica, los autores buscan documentación histórica sobre algunas cuestiones relacionadas con la construcción de su santidad, como la legitimidad del nacimiento de Laura y su rostro.
History, Heritage and Identity: conceptions of Ibero-American history teachers about heritage and identities
Authors: Ortuño Molina Jorge , Molina Puche Sebastián , Pinto Helena , Rivero Pilar
Published: October 2023

This paper analyzes the conceptions of Ibero-American secondary school teachers about the role of history teaching in creating collective identities, and how heritage can impact history classes. We applied a peer validated questionnaire to 283 history teachers from seven countries, analyzing their answers using a deductive-inductive method supported by IBM SSPS software (version 23). The analysis reveal that heritage continues to have little presence in lessons, mostly used as an example of historical narratives that highlight the national identity over others.