bluuebunny/crossref_metadata_2025 huggingface dataset:
Hartwalzen zur Festigkeitssteigerung wälzbelasteter Funktionsflächen
Authors: Hochbein Helmut , Appelt Sascha
Published: September 2021

The service life of functional surfaces subjected to rolling loads is limited by fatigue or insuffi cient separation of the rolling partners in the event of inadequate lubrication. These failure mechanisms can be counteracted by hard rolling and thus the introduction of residual compres sive stresses into the border zone, which can, among other things, extend maintenance intervals of production or power generation plants.
Einfluss der Polymerfunktionalisierung auf Adhäsion, Reibung und Formverschmutzung
Authors: Kröger Matthias , Haupt Stefanie , Krüger Jörn
Published: September 2021

At the IMKF, eight different elastomer compounds with different polymer compositions were examined for their demolding characteristics and mold fouling. Ten demolding cycles were carried out for each compound and the fouling of the mold was photo-technical recorded after ten demolding cycles. The used polymer composition does not seem to have any significant influence. However, the components of the compound have a significant influence on the friction characteristics while removing of the vulcanizate from the mold. Crosslinking that begins very early has an initiating influence on mold fouling. The measurable fluctuations in the maximum demolding force that occur could correlate with the internal friction of the polymer with the filler.
Interactive technologies for motivating students to learn foreign languages
Authors: Zaitseva Kateryna , Burkovska Zoriana , Кornienko Ludmila , Nikolska Nina , Moroz Olena
Published: September 2021

The article aims to establish the feasibility of interactive technologies in the study of foreign languages, as well as increasing student motivation through the active involvement of interactive technologies and assess the attitude of participants in the educational process to informatization of learning. The research methodology is based on a set of methods: questioning, interview method, observation, descriptive method. The main method in the work is the method of experiment. The result is to establish the level of motivation of students in the conditions of involvement of interactive technologies in learning. Prospective in further research further work on the development of interactive technologies, adapted for educational purposes, determining the level of motivation of students to learn foreign languages.
Economic efficiency of smart production: from targets to regulations
Authors: Merzlikina Galina Stepanovna
Published: September 2021

The article deals with the problems of assessing the economic efficiency of smart production and ways to resolve them. It has been found that Smart Manufacturing is currently becoming a goal in itself and a guarantor of successful development of industrial business. A comparative analysis of scientific publications to clarify the content of the concept of Smart Manufacturing is carried out, it is revealed that it is necessary to distinguish between intelligent and smart production, which are currently used as synonyms. Analysis of the practice of organizing smart manufacturing has shown that often the process of creating Smart Manufacturing pursues the goal of participating in a popular, useful process with the expectation of future “blurry” positive results; but there are also the actual results in the form of cost savings (better organization of the production process), an increase in production and an increase in labor productivity. All enterprises and organizations quite clearly understand the process of creating a specific smart production with detailing of individual stages, therefore, the specific goals of Smart Manufacturing should be specified taking into account a specific enterprise, but at the same time, standardized for the possibility of a comparative assessment of economic efficiency. It has been proved that traditional economic indicators of efficiency are used to assess the economic efficiency of Smart Manufacturing; but for the organization it is necessary to form a special system of performance indicators based on the theory of management by goals. It is determined that the main factor of Smart Manufacturing is innovative capital, since smart manufacturing is innovative by definition. Possible options for the formation and combination of goals and objectives of Smart Manufacturing and innovation capital are considered. The content and structure of the regulation for assessing the economic efficiency of Smart Manufacturing are proposed
Is There a Moral Intention to Reproduce Someone Else?
Authors:   Chief Assistant Professor, Medical University – Pleven, Bulgaria, Anov Atanas ,   E-mail: atanas.anov@gmail.com
Published: September 2021

"Moral intentions could be used as criteria for actions. In medical practice, moral intentions take an interesting form when the problem is related to post-mortem reproduction. This paper will attempt to 1) interpret the problem of intentions from principalist perspective in medical ethics; 2) relate the problem of intentions to post-mortem reproduction; 3) develop an existentialist account for intentions and post-mortem reproduction. Peter Zhu’s case is the latest ethical challenge in post-modern reproduction. Its moral sensitivity is high due to his presume intent to reproduce and the possibility for post-mortem reproduction using donors’ material and a surrogate mother. If we presume that the concept of presume intent lies with the general idea for intentions, we must tackle the problem from the perspective of respect for autonomy. The problem with intentions is that the prospective intentional action to reproduce belongs to one person only. Yet it appears that someone else is going to perform this action and someone else will finish it. Who should we hold responsible for this action: the person who intended to do it or the person who is intending to perform it and finish it? In Peter Zhu’s case, there are participants with different intentions that are with different moral value. The existentialist account of post-mortem reproduction and intending to reproduce will try to present why we should be careful with respect for autonomy. The ethical and existential consequences of such reproduction are that the future child would be brought to a life of suffering and vagueness. "
Ethical Issues in the Deactivation of Total Artificial Heart Support – A Systematic Review
Authors:   PhD Student, U.M.F Gr. T. Popa, Iași, România, Bacusca Alberto Emanuel ,   E-mail: bacuscaalberto@yahoo.ro, Birlescu Andreea Elena ,   PhD Student, U.M.F Gr. T. Popa, Iași, România; E-mail: birlescua@yahoo.com, Gavriluta Cristina ,   Universitatea Al.I. Cuza, Iași, România, Tinica Grigore ,   U.M.F. Gr. T. Popa, Iași, România, Ioan Beatrice Gabriela ,   U.M.F. Gr. T. Popa, Iași, România
Published: September 2021

"Introduction: In the context of a relatively constant heart donation rate, the effort to satisfy the needs, has led to the development of mechanical devices that can replace the cardiac function. Estimating an annual potential of 100,000 artificial heart implants in the United States alone, there is an increased interest in these devices, which is why it is appropriate to explore the situations where its inactivation may be ethically appropriate. Method: We performed a systematic review, which includes all the studies regarding the dilemma of artificial hearts inactivation from the beginning until 2020, published in PubMed, Embase and Scopus. The searched keywords were “totally artificial heart and ethics”; the duplicate studies and those referring to other cardiac support devices were excluded. Results: Following the selection, 12 articles were included in the review. The conflict between the principle of discontinuity and the prohibition generated by the indispensability of the artificial heart was emphasized. The decision to inactivate the support dependent on the patient’s declared level of happiness or clinical evolution over time was reviewed. The dilemma of self-inactivation of artificial cardiac support as suicide versus the acceptance of death caused by the underlying heart condition, as well as the impact of total removal of the native heart were included in the ethical analysis. Conclusions: Requests for withdrawal of TAH support are not uncommon among patients, their discontinuation being ethically acceptable when it does not serve the patient’s interests, even though they may still be capable to prolong their life. "
Everyday Ethical Challenges and Informal Ethics Support Structures of Migrant Caregivers in Older Adult Care in England
Authors:   DPhil candidate, University of Oxford, United Kingdom, Bandara Kumeri ,   E-mail: kumeri.bandara@ethox.ox.ac.uk
Published: September 2021

"This paper builds on anthropological fieldwork I conducted in 2019 while living for over two months with migrant caregivers of older adults in Epsom, England. Caregivers’ experiences resonated with existing literature on everyday ethical challenges in caregiving: navigating divergent perspectives on good care, negotiating professional disagreements on treatments, dealing with older adults’ verbal and physical abuse appropriately, and telling older adults ‘white lies’ to avoid mental distress. Caregivers also faced unique ethical challenges because of their migrant identities: dealing with racism, conscientious objecting of certain requests made by older adults, struggling with language when following training and defending themselves against exploitative managers, and carrying the burden of being a translator to fellow migrant colleagues. Based on insight into ethical challenges unique to migrant caregivers, this paper focuses on informal ethics support systems on which migrants relied ‒ an unexplored area in the literature on ethics support within social care ‒ and explores formal ethics support systems that could support migrant caregivers in the future. Existing literature shows that the UK in general lacks ethics support systems to help caregivers recognize and appropriately address ethical challenges. The literature goes on to explore kinds of formal ethics support systems that could address ethical challenges. However, the literature completely overlooks needs and challenges unique to migrant caregivers who increasingly constitute the older adult care workforce in the UK. Understanding everyday ethical challenges and informal support systems of migrant caregivers are important steps in ensuring wellbeing of caregivers, and thus, quality of care. "
Publico – A Digital Tool for Pandemic Crisis Communication and Management
Authors:   Prof. Dr. med. Dr. phil., Institute of Biomedical Ethics, University of Zurich, Zurich, Switzerland, Biller-Andorno Nikola ,   E-mail: biller-andorno@ibme.uzh.ch, Spitale Giovanni ,   Institute of Biomedical Ethics, University of Zurich, Zurich, Switzerland, Schwind Bettina ,   Institute of Biomedical Ethics, University of Zurich, Zurich, Switzerland, Jafflin Kristen ,   SwissTPH, Basel, Switzerland , Kaiser-Grolimund Andrea ,   University of Basel, Switzerland, Merten Sonja ,   SwissTPH, Basel, Switzerland 
Published: September 2021

"COVID-19 vividly demonstrates the global challenges of crisis communication. A flood of pandemic-related information from various sources and highly variable quality is inundating media platforms. To counter this “infodemic”, providing high-quality information is not sufficient. Real-time feedback loops from the public to policy-makers are urgently needed to better align communication strategies, actions taken, and public perception. To achieve this, the PubliCo online platform was launched in November 2020 in Switzerland. It follows a transdisciplinary multi-stakeholder approach rooted in participatory citizen science. PubliCo (https://publico.community/en/) includes three parts: 1. PubliCo Survey, collecting quantitative data, e.g. on moral preferences, while feeding back contextualized, tailored information to users; 2. PubliCo Diaries, collecting in-depth qualitative data, which also informs efforts to adapt PubliCo Survey to the evolving situation; and 3. PubliCo Analytics, which allows policymakers and other platform users to continuously analyse the collected data. We will present the PubliCo concept, considering the following key points: 1. Ethical considerations in the development of PubliCo concerning citizen science and crisis management. 2. PubliCo as a practical tool to implement the procedural ethics concepts such as Accountability for Reasonableness. 3. Lessons learned challenges, and opportunities for the transferability of PubliCo to better manage future crises in different global contexts. With our contribution, we aim to simulate a discussion on the ethical aspects of crisis communication and the strengths and limitations of citizen participation. "
Clinical Ethics and Disorder of Consciousness
Authors:   Postdoc, University of Milan, Italy, Derchi Chiara-Camilla ,   E-mail: camilla.derchi@gmail.com, Ceruti Silvia ,   PhD Student, University of Insubria, Varese, Italy; E-mail: ceruti.silvia@gmail.com, Giubbilo Ilaria ,   Independent Researcher, Italy
Published: September 2021

"Disorders of Consciousness (DOCs) identify a diverse group of dysfunctions affecting individuals who have survived severe brain damage. Although the clinical evaluation of patients with DOC normally depends on their residual ability to create a connection with the outside world through motor behavior, in the last ten years neuroscientists have made a great effort to better characterize the patient’s consciousness even in the case of reduced or no motor reactivity. Often, in fact, patients with DOCs are not able to perform any type of movement or adequately understand the command required but they might be still conscious or at least minimally conscious. The gap between patients’ motor capability and their residual brain complexity raises important moral issues, especially about appropriateness and proportionality of interventions and treatments. We argue that Clinical Ethics Consultation may be crucial in addressing these clinical scenarios, which assume aspects of further drama when the DOC derives from a sudden and unexpected acute event such as a trauma or a cerebrovascular accident in healthy patients. In these situations, given the particular vulnerability of the patients and the unpredictability of the diseases, Ethics Consultants should be involved in the therapeutic process in order to improve the standard of care, ensuring compliance with the inclinations and desires of the patients. Moreover, Ethics Consultants should monitor that the procedures are rigorously managed in the context of fully understood consent of those who are legally entitled to make decision. "
Ethical Approach to Road Traffic Injuries Prevention
Authors:   MD, PhD (c), assistant professor, Department of Preventive Medicine, ", Cociu Svetlana ,   Nicolae Testemitanu",   State University of Medicine and Pharmacy, Chisinau, Republic of Moldova,   E-mail: svetlana.cociu@usmf.md
Published: September 2021

"Road traffic injuries are widespread public health problem, particularly in low- and middle-income countries, being the leading cause of death for children and young adults aged 5–29 years. Road injury ranks 8th after the main causes of death, and unless there will not be a complex approach to prevention those will rank 5th by 2030. The Republic of Moldova is characterized by a high mortality due to road crashes, children and adults over 50 years are more prone to injury or a road crashes and the age group 15-39 years there is a higher risk of death as driver or passenger in a transport unit. Road traffic injuries can be prevented, and many government interventions, policies and programs have been proposed in order to prevent road injuries, but their prevention was less approached by applying and respecting ethical aspects among all the participants in traffic. Each one involved in the road traffic can contribute in improving the road safety by his/her responsibility, which refers to consciousness, morality, ethics and ethical behavior, culture. Drivers and pedestrian have the moral duty while driving to use seat belt, comply with road traffic rules and safety requirements and have duty not to harm- to avoid putting themselves and others in danger. We need much more understandings of the behavior risk factors, increasing psychological capacity and benefits, investing in educational campaigns, effective communication, social support, and encouragement, increase awareness of responsibility in traffic and increasing respect for all participants in traffic, without causing any harm. Acknowledgement: Rosamond Rhodes, Ph.D., Professor of Medical Education, Director of Bioethics Education, Icahn School of Medicine at Mount Sinai, New York, USA. "
Life Quality of Patients with Face Transplant
Authors:   Medical Doctor, Phd Student, Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania, Covrig Vlad ,   E-mail: vlad_cov@yahoo.com, Budacu Cristian ,   Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania, Ioan Beatrice ,   Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania
Published: September 2021

"The face is the feature which best distinguishes a person, the shape of it being influenced by the bone-structure of the skull. Facial trauma, known as maxillofacial trauma, is any physical trauma to the face that can involve soft and hard tissue having the potential to cause disfigurement. The last resort solution after major facial trauma, when conventional reconstruction techniques have failed is now represented by face transplant. The aim of this paper is to underline the life quality and psychological implication of patients that were face transplanted. Our material and method involved studying the most relevant medical literature for this issue and also using our personal experience of patient with face cancer that underwent radical oncological surgery followed by reconstruction. Based on these data we can conclude that face transplantation appears to decrease depression and to improve patient’s quality of life and societal reintegration. Also, in our opinion a very important factor involving the success of face transplantation is represented by the psychological outcomes of the patients, their follow up for a minimum 6 months period with regular psychological counselling sessions being very important. Furthermore, there is a critical need for modification of existing rating scales to allow effective assessment of face transplant candidates before and after transplantation. "
Ghostwriting and Authorship Practices in Biomedical Research: A Study Protocol
Authors:   Department of Medical Informatics and Biostatistics, ", Cozma Alina-Georgiana ,   Iuliu Hațieganu",   University of Medicine and Pharmacy, Cluj-Napoca, Romania,   E-mail: cozma.alina.georgiana@elearn.umfcluj.ro, Aluaș Maria ,   Department of Oral Health, „Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; E-mail: maria.aluas@umfcluj.ro, Bolboacă Sorana D. ,   Department of Medical Informatics and Biostatistics, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania
Published: September 2021

"Background: Scientific paper authorship represents an important form of academic attainment for research professionals and brings specific benefits (e.g., contribution science, recognizing the author’s intellectual efforts). Authors certify their work’s integrity by accepting the responsability of the published content. The principal two important unethical authorship is honorary authors (the criteria of authorship not met) and ghost authors (contributed substantially but not listed as an author). Aim: The current study has two-fold aim: to determine the prevalence of authorship violations in the biomedical journals according to the Web of Science classification and to evaluate its variation by article type (e.g., research, review, or editorial) and presence/absence authors contributions requirements. Materials and Methods: The following steps will be apply: 1) Identification of journal categories of interest – data source: Journal Citation Reports 2020 (JCR2020); 2) Identification of the eligible journal – JCR2020 by selection of journals weighted according to the number of jorunals in a specific category. The selection will be stratified by the Rank by Journal Citation Indicator (JCI); 3) Collection of characteristics of the included journals regarding the year 2020: total number of articles, number of articles and references, number of reviews and associated references; JCI percentile, open access policy and publication fee if applicable; 4) Random selection (simple random method) of authors who published in 2020. The selection will be done weighted according to the number of manuscripts published in 2020; 5) Development and validation of the questionnaire; 6) Invitation of the corresponding author to participate in the study; 7) Online anonymously data collection. The study protocol will be deposited in an international database. "
PENGARUH INTENSITAS PENDAMPINGAN, PENDANAAN DAN LITERASI KEUANGAN TERHADAP STATUS KEBERHASILAN PROSES INKUBASI TENANT INKUBATOR BISNIS
Authors: Puspita Yanti Ni Putu Yayuk , Dewi Made Heny Urmila
Published: September 2021

The purpose of this study was to analyze the effect of the intensity of mentoring, funding, and financial literacy simultaneously and partially on the success status of the business incubator tenant incubation process in Bali Province. This study uses primary data by distributing questionnaires to 97 business incubator tenants in Bali Province. The analysis technique used is multiple linear regression which is equipped with a classical assumption test. The results of the test analysis in this study indicate that simultaneously the intensity of mentoring, funding, and financial literacy has a positive and significant effect on the success status of the business incubator tenant incubation process in Bali Province. Partially, the intensity of mentoring and financial literacy has a positive and significant effect on the success status of the business incubator tenant incubation process in Bali Province, while partially funding has a negative and significant effect on the success status of business incubator tenants in Bali Province. The government is expected to develop superior local products from upstream to downstream as the basis for cooperative business and MSME, strengthening the synergy and orchestration of cooperative and MSME-based people's economic development with all ministries and all business stakeholders.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEUNTUNGAN PEDAGANG SOUVENIR DI KECAMATAN UBUD, KABUPATEN GIANYAR, BALI
Authors: Rahsyani Anak Agung Karin , Putu Widanta Anak Agung Bagus
Published: September 2021

The profits obtained by souvenir traders in Ubud District, Gianyar are determined by several factors, some of which are working capital, working hours, product quality, and sales volume. This study aims to analyze the effect of working capital, working hours and product quality on profits with sales volume as an intervening variable for souvenir traders in Ubud District, Gianyar. In this study using primary and secondary data through direct interviews to 89 respondents with the sampling method Proportional Stratified Random Sampling. The data analysis technique is in the form of descriptive analysis technique and path analysis. The results showed that working capital, working hours, product quality, and sales volume had a positive effect on the profits of souvenir traders in Ubud District, Gianyar. The suggestion that can be given in this research is to increase the profit of souvenir traders in Ubud District, Gianyar, it is better to optimize working capital, working hours, product quality and sales volume so that the profits obtained are greater.
ANALISIS DETERMINAN PENDAPATAN RUMAH TANGGA MISKIN DI KECAMATAN KARANGASEM
Authors: Wiguna I Nyoman Bayu Sugiarta , Karmini Ni Luh
Published: September 2021

Poverty is the biggest challenge faced by the world and is one of the three main problems that exist in economic development in the world. This study aims to analyze the effect of education, age, and work participation of family members simultaneously and partially on the income of poor households in Karangasem District. This research was conducted in Karangasem sub-district with a total sample of 100 respondents using the sampling method, namely proportionate random sampling and data collection methods, namely observation, structured interviews, and in-depth interviews. The data analysis technique used is multiple linear regression. The results of this study indicate that the variables of education, age, and the level of work participation of family members simultaneously have a significant effect on the income of poor households in Karangasem District. The variables of education, age, and participation level partially have a positive and significant effect on the income of poor households in Karangasem District.
Caracterización de funciones frontales y ejecutivas en pacientes heroinómanos en tratamiento con metadona
Authors: Correa-Pérez Luisa Fernanda , Rincón-Barreto Dubis , Zapata Zabala Maryoris , Germán Wilmot Leandro José , Martínez Pérez Juan Fernando , Cuartas Jorge Mauricio
Published: September 2021

Con el propósito de determinar las características de las funciones frontales y ejecutivas en pacientes heroinómanos, hombres (n: 45) en tratamiento con metadona de la E.S.E Hospital Carisma en Antioquia, se diseña un estudio observacional descriptivo, y se aplican el Test Breve de Inteligencia de Kaufman y la Batería Neuropsicológica de las Funciones Ejecutivas y Lóbulos Frontales (BANFE). Los resultados permitieron establecer que el funcionamiento ejecutivo en estos pacientes presenta en la mayoría (n=66,6%) una alteración severa en tareas de autocontrol, toma de decisiones y regulación emocional, asimismo, se evidencia alteración en las áreas dorsolateral, orbitofrontal y frontomedial.
Análisis exploratorio sobre violencia filio-parental en una muestra de adolescentes mexicanos
Authors: Romero-Méndez Christian Alexis , Cancino-Padilla Daniela , Rojas-Solís José Luis
Published: September 2021

El presente estudio tuvo como objetivo analizar la frecuencia de la violencia filio-parental (VFP) en una muestra de adolescente mexicanos, para ello se empleó un enfoque cuantitativo, con un diseño no experimental, de corte transversal y ex post facto; con alcances exploratorios y descriptivos. La muestra fue seleccionada de manera no probabilística e intencional, participaron 407 adolescentes, 214 mujeres y 193 varones, con edades comprendidas entre los 12 a 18 años, los cuales fueron agrupados de acuerdo a la convivencia con sus padres o madres. El instrumento utilizado para detectar la VFP fue la Adaptación del Cuestionario de violencia filio-parental en adolescentes mexicanos (Calvete y Veytia, 2018), el cual evalúa la frecuencia de la perpetración de la violencia psicológica y física de los hijos o hijas hacia sus progenitores. Los resultados señalaron la existencia de la violencia filio-parental, siendo la violencia psicológica cometida hacia la madre y hacia al padre la que con mayor frecuencia se ejerció por ambos sexos; datos que son congruentes con lo hallado en otras investigaciones. En las diferencias por sexo únicamente se identificó diferencia estadísticamente significativa para los adolescentes que indicaron vivir o haber vivido con ambos padres, siendo los varones mayormente perpetradores de violencia física hacia el papá en comparación con las mujeres. A manera de conclusión se sugiere seguir explorando el fenómeno debido a que la literatura científica y académica continúa siendo escasa en regiones como México y América Latina.
Cloning, Expression, Purification, and Oligomeric Characterization of the AopB-C-terminus Domain in T3SS Major Translocator Protein of Aeromonas hydrophila
Authors: Van Sang Nguyen , Uyen Nguyen Thi
Published: September 2021

Type three secretion system (T3SS) is found exclusively in gram-negative pathogens such as Yersinia spp., Escherichia coli, Salmonella spp., Shigella spp., Pseudomonas spp., Vibrio parahaemolyticus, and Aeromonas hydrophila. The translocon pore of T3SS comprises major and minor translocator proteins that assemble to provide passage of effectors through the host cell membrane. Major translocator protein AopB from Aeromonas hydrophila plays an important role in translocon pore formation. Despite tremendous efforts, structural information regarding the C-terminus domain of major translocator AopB remains elusive. In this study, the DNA fragment encoding for the C-terminus domain of the AopB major translocator from Aeromonas hydrophila AH-1 was cloned in to pET-M expression vector and expressed in BL21 (DE3) host cells. The recombinant AopB-C-terminus domain was successfully purified using immobilized nickel affinity chromatography as a soluble form. Crosslinking analysis among AopB-C-terminus molecules in solution showed that this domain exists as a mixture of tetramer, trimer, dimer and monomer forms. The three-dimensional structure model of AopB-C-terminus oligomerization was built by SWISS-MODEL and PyMol. The oligomeric model of AopB-C-terminus can be used for structural studies of the AopB-C-terminus domain which can contribute to the elucidation of the structure of the type III secretion system.
Cobalt Chloride Alters Mitochondrial Function in a Dose Dependent Manner
Authors: Bich Pham Thi , Thu Vu Thi
Published: September 2021

Aim: This study was carried to evaluates of Cobalt chloride (CoCl2) on cardiac mitochondrial function. Methods: H9C2 cardiomyocytes were cultured in medium containing different concentrations of CoCl2. Cell viability, cardiolipin content, mitochondrial function, and mitochondrial oxidative stress were assessed by using Cell Counting Kit-8 and suitable fluorescence kits. Results: The obtained data showed that CoCl2 (200÷400 µM) induced cell death and decreased mitochondrial function of H9C2 cardiomyocytes in dose dependence. Especially, CoCl2 at dose of 300 µM significantly altered values of mitochondrial membrane potential, H2O2 and O2- to 63.79±2.15%, 145.81±5.83% and 143.10±3.07% (of 100% control), respectively. Conclusion: CoCl2 strongly induced cardiomyocyte death via altering mitochondrial function in a dose-dependent manner.
Detection of MicroRNAs in Extracellular Vesicles Secreted by Umbilical Cord-derived Mesenchymal Stem Cells
Authors: Huyen Nguyen Thu , Chau Duong Minh , Phuong Do Thi Xuan , Liem Nguyen Thanh , Uyen Than Thi Trang
Published: September 2021

Extracellular vesicles (EVs) are emerging as a potential candidate for disease treatment due to their bioactive cargoes. Recently, mesenchymal stem cells (MSC)-derived EVs have shown their capacity to replace parental cells as their similar functions to MSCs. The therapeutic effects of EVs depend on their cargo, such as DNA, miRNA, proteins, and lipids. In this study, we expanded umbilical cord-derived MSCs (UCMSCs) for EV release. Additionally, we evaluated the expression level of several microRNAs in three EV populations, including apoptotic bodies (AB), microvesicles (MV), and exosomes (EX). Results showed that UCMSCs released three EV types: AB, MV, and EX into culture media. The three EV populations were different in morphology and size. Three EVs were detected to carry microRNAs, such as hsa-miR-320, hsa-miR-181b, and hsa-miR-140. Among these microRNAs, hsa-miR-140 expressed with the greatest level, followed by hsa-miR-181b and hsa-miR-320. The results of this study provide more knowledge about UCMSC-derived EV miRNAs in addition to reveal the potential role of UCMSC-EVs associated with detected miRNAs.
Cross-lexicographic analysis of the concepts of sociopolitical discourse of the Chinese language
Authors: Kruglov Vladislav , Uryvskaya Tatiana , Rusak Dmitrii
Published: September 2021

The object of this research is the concepts of sociopolitical discourse of the Chinese language, selected by the continuous sampling method. The subject of this research is the cross-lexicographic coefficient, which is derived mathematically within the framework of the cross-lexicographic analysis of these concepts. The goal is set to determine the diachronic changes in the meanings of lexemes of sociopolitical discourse via cross-lexicographic analysis based on dictionary materials compiled by the prominent Russian and foreign sinologists over the period from 1888 to 2002. Attention is drawn to such theoretical concepts as semantics, pragmatics and discourse. Description is given to the key characteristics of sociopolitical discourse, as well as the methodology of formation of the corresponding conceptual apparatus. The research leans on the method of continuous sampling from lexicographic sources. The scientific novelty lies in the development of innovative methods of statistical analysis of the conceptual apparatus of sociopolitical discourse of the modern Chinese language. Among the acquired results, the author notes the transformation of meanings of the selected lexemes through the analysis of metalanguage of the dictionaries. The uniqueness of this article consists in the analysis of the vast range of the previously unpublished archival lexicographic sources of the Chinese language. The author also reveals the dynamics of changes in the selected lexical means by means of the derived cross-lexicographic coefficient, as well as determines the key vectors of their discursive transformations and evolution of linguopragmatic functions.
Gramaticalização e gramática gerativa: Fundamentação, o problema mente/corpo e domínios de validade
Authors: Vitral Lorenzo
Published: September 2021

Trata-se aqui de um trabalho de natureza epistemológica/historiográfica que coteja duas perspectivas teóricas: a Gramática Gerativa) e a Gramaticalização, tomando como base empírica os tratamentos propostos ao fenômeno da negação em várias línguas. Propomos que há correlação entre proposições ou entidades concebidas nos dois quadros teóricos, mas que essas correlações não são de valor nomológico, o que desfavorece a unificação dos dois campos teóricos e reforça a concepção de autonomia teórica do quadro da gramaticalização.
Relação gestos/sinais em Libras: uma análise baseada no contínuo de Cornelia Müller
Authors: Porto Marcelo
Published: September 2021

No início dos estudos das línguas de sinais, os pesquisadores limitaram-se a argumentar sobre a dimensão sistêmica dessas línguas, sem considerar a questão da gestualidade. Atualmente, entretanto, o estatuto da gestualidade nos estudos das línguas de sinais tem se tornado objeto de reflexão com a ascensão de diferentes perspectivas teóricas. Este trabalho situa-se nesse contexto e visa a refletir criticamente sobre a proposta teórica de Müller (2019) acerca da relação de gestos/sinais tanto no âmbito dos estudos de línguas orais quanto no das de sinais, explorando sua teoria empiricamente na Língua Brasileira de Sinais (Libras). Müller (2019) propõe um contínuo gestual composto por gestos singulares, gestos recorrentes, emblemas e sinais, e tal proposta é discutida por meio de uma metodologia descritiva e interpretativa baseada em dados em Libras da “história da pera” criada pelo linguista Wallace Chafe (1980) em Libras. Os resultados indicam a possibilidade de a maioria das ações manuais na narrativa atenderem aos critérios de convencionalidade, composicionalidade e relação forma-significado definidos pela autora, mas também levantam questões no que diz respeito às realizações de boias e de sinais em contextos de ação construída em Libras. Como conclusão, apontamos para a insuficiência de uma abordagem gestual de cunho “lexicalista” para explicação dos fenômenos gestuais que ocorrem no campo discursivo das línguas de sinais e da Libras, na qual esta análise se baseia.
Manifestações clínicas e desfecho gestacional ocasionados pela infecção por COVID-19
Authors: Rodrigues Gabriel Torga Saade , Martins Bruna Cristina Silva , Campos Daniel Caires , Medeiros Helena Maia Ferreira de Paula , Andrade João Marcelo Feitoza de , Aquino Lorenna Lemos de , Rocha Maria Alice Batista , Vieira Maria Eduarda Venturim Almeida , Cota Maria Gabriela Prandini Nunes , Campos Gabriela Gonçalves
Published: September 2021

Objetivo: Elaborar uma revisão narrativa da literatura com a finalidade de relatar as principais manifestações clínicas e os desfechos gestacionais até o momento em gestantes com COVID-19 (infecção respiratória aguda causada pelo coronavírus SARS-CoV-2). Revisão bibliográfica: A gravidez acarreta várias mudanças fisiológicas e imunológicas, a qual o corpo fica mais suscetível a infecções por patógenos respiratórios e desenvolvimento de pneumonias graves, que é considerada a terceira causa indireta mais frequente de morte materna. O quadro clínico em gestantes com COVID-19 é capaz de se manifestar assintomática, bem como de forma sintomática grave, necessitando de tratamento em unidade de terapia intensiva. Partos prematuros, pneumonia neonatal e transmissão vertical foram associados a bebês de mães infectadas pelo COVID-19. Considerações finais: Isto posto, torna-se necessário um cuidado especial por parte da equipe com a gestante. Entretanto, o isolamento social é a melhor forma de combater o vírus e evitar suas complicações, uma vez que a imprevisibilidade dessa doença pode ocasionar um desfecho agressivo para o feto, além de complicações severas para a mãe.
Pattern of Orthopedic Trauma during COVID-19 Crisis in Saudi Arabia: Report from Level I Trauma and COVID-19 Center
Authors: Sadat-Ali Mir , Al-Dakheel Dakheel A. , Al-Omran Abdallah S , Al-Mousa Sulaiman A. , Al-Sayed Hasan N. , Bubshait Dalal A , AlOmran Ammar K , AlQahtani Saad M
Published: September 2021

Objectives:

The aim of this study was to provide the pattern of orthopedic trauma catered at our center during the lockdown to stop the spread of SARS-CoV-2 and compare it during the same period in the preceding year.

Methods:

A retrospective study of all trauma patients operated during partial and total lockdown during March– July 2020, was conducted at the orthopedic department of King Fahd Hospital of the University, Al-Khobar. The data collected were age, gender, reason for hospital admission, date of injury and presentation, length of stay, and treatment provided. The exposure and transmission of the COVID-19 to healthy orthopedic staff were recorded.

Results:

During the lockdown, there were 71 admissions compared to 110 the year before, with a drop of 39 (35.4%) patients. The drop in the number of women and children was statistically significant (P < 0.05 and < 0.001, respectively). The majority of injuries were sustained from domestic accidents and road crashes. There was a significant increase in fractures of the vertebral column and distal radius (P < 0.002 and < 0.05, respectively). In the pre-COVID-19 period, the average time to discharge was 18.90 ± 12.74 days and the average time to discharge in COVID-19 period was 4.28 ± 3.52 days. Four orthopedic staffs were exposed to COVID-19-positive patients and one of the surgeons became positive.

Conclusion:

The COVID-19 pandemic decreased orthopedic trauma admissions by 35% during the lockdown period and early surgery and discharge of the patients was possible due to proper planning.
Presencia, identidad y afectividad en “Los heraldos negros”, de César Vallejo. Apuntes de hermenéutica semiótica
Authors: Quezada Macchiavello Óscar
Published: September 2021

Hay dos razones, o quizá indisposiciones, que me han provocado siempre cierta reticencia a emprender el análisis o aún el mero comentario de la obra de un poeta. La primera concierne a la objetiva dificultad que entraña involucrarse, adentrarse, compenetrarse, bucear en el caudal simbólico del texto poético. Este, por la complejidad del entramado de sus niveles y de sus figuras de composición (y de descomposición), es el que con más fuerza pone a prueba la consistencia de una elaboración teórica y la coherencia de sus respectivos procedimientos metodológicos.

La segunda concierne a la ingenua concepción instrumental del lenguaje como algo exterior a los actores individuales o sociales que, lamentablemente, predomina en la crítica literaria habitual. Frente a ella, la metodología semiótica entiende un fenómeno de lenguaje como acontecimiento que constituye al ser humano haciéndolo carne-cuerpo-sujeto de comunicación. Dicho en breve, si biológicamente somos de ADN, semióticamente somos de lenguaje. Y existir es hacer discurso de ese ser lenguaje. Así pues, cualquier discurso entraña en su entraña un proceso de significación asumido por una enunciación.
Desvíos de la pandemia
Authors: Universidad de Lima Círculo de Fotografía
Published: September 2021

Muestra fotográfica del Círculo de Fotografía de la Universidad de Lima, integrada por  jóvenes estudiantes de nuestra casa de estudios, quienes transmutan el quebranto y la incertidumbre de una ciudad sitiada en una vibrante expresión estética.
Un reloj derramado en el desierto
Authors: Susti Alejandro
Published: September 2021

Fragmento del libro galardonado con el Premio Internacional “Rubén Darío” en el 2020.
Trazos
Authors: Eslava Jorge
Published: September 2021

Es costumbre en el Perú que las fiestas cívicas y religiosas sean motivo de unión y regocijo. Responde a una necesidad de bienestar, de vivir en armonía a pesar de nuestra diversidad y desajustes. O, incluso, merced a ellos. Por eso solemos hacernos promesas para curar heridas históricas, colocar ofrendas de reconciliación entre hermanos y consagrar homenajes a santos o héroes con ánimo de emularlos. La gastronomía y el deporte, en la última década, parecían señalar un camino de concordia hacia la constitución de un país pródigo en tradiciones y valores.
Evidencias de validez y confiabilidad de la escala de flexibilidad en jóvenes mexicanos
Authors: Palacios Jorge
Published: September 2021

El objetivo de la investigación fue analizar la confiabilidad y validez de las puntuaciones de la escala de flexibilidad de Melgoza y Díaz-Guerrero (1990) en jóvenes mexicanos. Se aplicó la escala a una muestra de 309 jóvenes, de entre 14 y 24 años de edad, de la zona metropolitana de la Ciudad de México. Los resultados muestran la estructura factorial integrada por tres factores mediante un análisis factorial confirmatorio, referentes a la amabilidad, complacencia y adaptación conductual. Particularmente la amabilidad (β = .325, p <.001) y la adaptación conductual (β = .245, p <.001) son predictores de la eficiencia personal. Las puntuaciones de la escala alcanzan un índice de consistencia interna de .85 (IC95 % = .83 - .87). Se analiza la utilidad de los resultados para la evaluación de la flexibilidad y los rasgos de personalidad en los jóvenes, así como las implicaciones para futuras investigaciones sobre etnopsicología.
Watchmen: sobre las buenas intenciones y el miedo
Authors: Lemus Polanía Juan Carlos
Published: September 2021

En los momentos de crisis, sean personales o sociales, somos dados a mirar al pasado en búsqueda del instante en el que todo se quebró. El año 2020 será un período donde los que nacimos después de la década de los setenta sintamos el fin del mundo tan cercano como nuestros antepasados lo vivieron. Sí, de una manera u otra hemos sabido andar y reandar por estos desasosegados caminos. El universo Watchmen , que surge en el cómic y después fue adaptado al cine y la televisión, sirve como archivo y pronosticador al mismo tiempo.
El regreso de los virus mutantes. Invasiones, resistencias y pandemias. Diálogo entre Carlos A. Scolari y Ricardo Bedoya
Authors: Indiscreta Ventana
Published: September 2021

Presentamos un adelanto de esta conversación que será publicada de forma íntegra en el libro de Carlos Alberto Scolari No pasarán. Las invasiones alienígenas: de H. G. Wells a Steven Spielberg (y mas allá), que será lanzado por el Fondo Editorial de la Universidad de Lima.
El nuevo cine coreano: ferocidad y lirismo
Authors: León Frias Isaac
Published: September 2021

En la búsqueda por reconocer el punto de inicio del auge del cine surcoreano, se examinan algunas etapas que nos hacen ver que no se trata de un fenómeno tan reciente. Entre el crecimiento económico, la consolidación y la aparición de nuevos directores, acompañados de la presencia activa en festivales, se veía perfilar un auspicioso horizonte del que hoy podemos seguir apreciando los frutos y que siguen augurando un buen panorama.
Breve referencia al cine en la historia coreana (1897-2004)
Authors: Mera Arnaldo
Published: September 2021

Un repaso histórico al cine surcoreano desde sus inicios en el cine silente con temáticas basadas en historias tradicionales, pasando por etapas marcadas por las censuras de la dominación japonesa, hasta llegar a las grandes y premiadas producciones del siglo xxi. Acompaña cada etapa un contexto político y social que marca el difícil camino del cine de este país hasta alcanzar el reconocimiento internacional del que hoy goza.
Las edades del cine de Kim Ki-duk
Authors: Bedoya Forno Rodrigo
Published: September 2021

Mediante una revisión de algunas películas aparecidas en distintas etapas del prolífico realizador surcoreano, se reconocen los rasgos de su estilo: personajes marginados y obsesivos, la búsqueda de redención, la violenta representación de la sexualidad, entre otros temas que siempre le han preocupado y que supo mantener, aunque con ciertas variaciones, hasta el final.
La tristeza habitual: el cine de la directora Byun Young-joo
Authors: Moscol Brandy , Vidal Talía , Mora Jimena
Published: September 2021

A partir de que El murmullo, obra de la cineasta Byun Young-joo, ganara el Festival Internacional de Cine Documental de Yamagata, en Japón, se conoció la realidad que vivieron miles de mujeres esclavizadas durante la ocupación de Corea por Japón. He aquí la historia.
Por la senda del monstruo: la "Trilogía de la venganza" de Park Chan-wook
Authors: Baella Arsentales Agustín
Published: September 2021

Motivados por un sentimiento vengativo, que fomenta un círculo continuo de ira y resentimiento, los personajes de la “trilogía de la venganza” de Park Chan-wook, conformada por Sympathy for Mr. Vengeance, Oldboy y Lady Vengeance, van dejando de ser ellos mismos conforme van logrando sus objetivos. Una vez que cruzan la línea de víctima a victimario, no hay vuelta atrás. Caminan hasta convertirse en algo irreconocible, dejándonos una gran incertidumbre: una vez consumada la venganza, ¿qué es lo que sigue?
The rs5918 polymorphism in the ITGB3 gene increases the risk for preeclampsia in pregnant women with fetal growth retardation
Authors: Golovchenko Oleg V. , Ponomarenko Irina V. , Churnosov Mikhail I.
Published: September 2021

Aim. To assess the relationship of rs5918 ITGB3, rs1126643 ITGA2 and rs5985 F13A1 polymorphic loci with the risk for preeclampsia (PE) in pregnant women with fetal growth retardation (FGR).
Materials and methods. The study included 272 pregnant women, of which 76 had a combination of PE and FGR and 196 had FGR. In the studied groups, genetic testing was carried out for three polymorphic loci of candidate genes for hereditary thrombophilia (rs5918 ITGB3, rs1126643 ITGA2, and rs5985 F13A1).
Results. The rs5918 genetic variant in the ITGB3 gene is associated with the development of PE in pregnant women with FGR: C allele of rs5918 ITGB3 increases the risk for this complication of pregnancy by 1,8 times (OR 1.761.77, p0.036, pperm0.038). The rs5918 polymorphism determines an increase in the affinity of DNA motifs for seven transcription factors (BDP1, ELF1, IRF, NRSF, Pax-5, Sp1, and Zfx), is a missense mutation and causes the Leu59Pro amino acid substitution in the 3 subunit of integrin, is multidirectionally associated with the expression of five genes (EFCAB13, TBKBP1, NPEPPS, MRPL45P2, THCAT158) and alternative splicing of two genes (EFCAB13, MRPL45P2), is located in the region of functionally important DNA regions (promoters and enhancers) in cell cultures and organs which are pathogenetically important for the formation of PE and FGR.
Conclusion. The rs5918 polymorphism in the ITGB3 gene increases the risk for PE in pregnant women with FGR.