bluuebunny/crossref_metadata_2025 huggingface dataset:
Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency
Authors: Anderson Rebecca A. , Schwalbach Kevin T. , Mui Stephanie R. , LeClair Elizabeth E. , Topczewska Jolanta M. , Topczewski Jacek
Published: May 2020

Human disorders of the post-squalene cholesterol biosynthesis pathway frequently result in skeletal abnormalities, yet our understanding of the mechanisms involved is limited. In a forward-genetic approach, we have found that a late-onset skeletal mutant, named kolibernu7, is the result of a cis-acting regulatory mutation leading to loss of methylsterol monooxygenase 1 (msmo1) expression within pre-hypertrophic chondrocytes. Generated msmo1nu81 knockdown mutation resulted in lethality at larval stage. We demonstrated that this is a result of both cholesterol deprivation and sterol intermediate accumulation by creating a mutation eliminating activity of Lanosterol synthase (Lss). Our results indicate that double lssnu60;msmo1nu81 and single lssnu60 mutants survive significantly longer than msmo1nu81 homozygotes. Liver-specific restoration of either Msmo1 or Lss in corresponding mutant backgrounds suppresses larval lethality. Rescued mutants develop dramatic skeletal abnormalities, with a loss of Msmo1 activity resulting in a more-severe patterning defect of a near-complete loss of hypertrophic chondrocytes marked by col10a1a expression. Our analysis suggests that hypertrophic chondrocytes depend on endogenous cholesterol synthesis, and blocking C4 demethylation exacerbates the cholesterol deficiency phenotype. Our findings offer new insight into the genetic control of bone development and provide new zebrafish models for human disorders of the cholesterol biosynthesis pathway.
Did the new Law for State-owned Firms affect those that are publicly traded?
Authors: De Oliveira Vitor Kayo , Holland Marcio , Sampaio Joelson O.
Published: May 2020

This paper studies the effects of a new law aimed at state-owned enterprises in Brazil. In particular, it analyzes whether this legislation, promoting improved corporate governance, leads to a reduced perception of risks in the management of these companies and, therefore, in the volatility of their stock returns. To do this, the ArCo (Artificial Counterfactual) methodology is applied, using high-dimensional panel time-series data from 2011 to 2018. Our results show that thirteen out of twenty stocks present a reduction in their volatility, six out of twenty stocks have contradictory results and one stock does not present a statistically significant result.
Seleção de Carteiras: Escolha entre modelos baseada em persistência de performance
Authors: Tavares Ricardo de Souza , Caldeira João Frois
Published: May 2020

Este trabalho traz uma alternativa ao problema da escolha de estratégias para construção carteiras de investimentos. Foi proposto um procedimento para seleção de carteiras em que, a cada ponto do tempo, é escolhida a estratégia com melhor desempenho em uma janela de p observações recentes para determinado critério, com base a hipótese de persistência de performance. Foram considerados como critérios a média, variância e índice de Sharpe, visando a construção de sequências de escolhas de alocações que melhor se adaptassem aos diferentes contextos e bases de dados analisados. Os resultados encontrados indicaram que a abordagem sugerida foi capaz de gerar sequencias de alocações com bom desempenho em termos de retorno médio, risco e índice de Sharpe.
Analgesic efficacy of nefopam for cancer pain: a randomized controlled study
Authors: Pasutharnchat Koravee , Wichachai Wichita , Buachai Rungrawan
Published: May 2020

Background: Nefopam is a non-opioid, non-steroidal, central acting drug used effectively for postoperative pain. The efficacy of nefopam for cancer pain remains unclear. We aimed to evaluate the analgesic efficacy of nefopam for cancer pain in a randomized controlled trial.

Methods: Patients with moderate to severe cancer pain (n=40) were randomly divided into two groups. The nefopam group (n=20) received three 20 mg doses of nefopam every 8 hours. The placebo group (n=20) received normal saline. Intravenous patient-controlled analgesia with morphine was given for breakthrough pain for 48 hours. The primary outcome was significant pain reduction. Secondary outcomes were morphine consumption over 48 hours and incidence of side effects.

Results: The nefopam group showed pain reduction at 12 hours (65% of patients), 24 hours (80%), 36 hours (85%), and 48 hours (65%). The placebo group showed pain reduction at 12 hours (70%), 24 hours (75%), 36 hours (80%), and 48 hours (60%). However, there were no statistically significant differences between the groups (p>0.05). The median dosage of morphine consumption in 48 hours was lower in the nefopam group (25.5 mg) compared with the placebo group (37 mg), but this was not statistically significant (p=0.499). There were no statistically significant differences in blood pressure and heart rate between the groups. Side effects in both groups were comparable.

Conclusions: At dosage of 60 mg in 24 hours, nefopam did not provide significant pain reduction in moderate to severe cancer pain patients. However, there was a trend of reduced opioid consumption. Further studies with larger sample sizes, longer duration, or higher doses of nefopam are warranted.

Registration: Thai Clinical Trail Registry (TCTR) ID TCTR20181016001; registered on 12 October 2018.
Studying the Reasons for Resistance to the Project of Transferring the Company to an Automated Task Tracker and Developing Practical Recommendations for Overcoming Them
Authors: Shayahmedova Luiza , Gorodnicheva Anastasiya
Published: May 2020

This work is devoted to the analysis of the causes of resistance to the project of transferring a company unit to an automated task accounting system and the development of practical recommendations for overcoming it. As a research base, the results of the developed testing of employees of the company of various departments that were affected by the changes were used. The results of the work are an analysis and explanations of the petal diagrams based on the responses of the respondents. In this paper, the main objects of resistance were identified and the reasons for their occurrence were explained. As a solution, recommendations for their elimination or workarounds for overcoming problems are proposed.
Implementation of virtual reality (VR) in diagnostics and therapy of nonaffective psychoses
Authors: Kruk Dawid , Mętel Dagmara , Gawęda Łukasz , Cechnicki Andrzej
Published: May 2020

Immersyjna wirtualna rzeczywistość to technologia, która pozwala na zanurzenie się w wirtualnym świecie w odcięciu od bodźców zewnętrznych. Umożliwia to symulację różnych sytuacji społecznych, często niemożliwych do zaaranżowania w rzeczywistości, z zachowaniem wysokiej kontroli zmiennych zakłócających. Dzięki realizmowi odbiorca tej rzeczywistości zachowuje się podobnie i doświadcza emocji podobnych do tych przeżywanych w warunkach naturalnych, co skutkuje wysoką ekologiczną trafnością tego środowiska i czyni je użytecznym dla celów diagnostyki i terapii. W niniejszym przeglądzie, wykonanym w sposób narracyjny, przedstawiono wyniki badań obserwacyjnych i interwencyjnych wykorzystujących immersyjną wirtualną rzeczywistość (ang. VR – Virtual Reality) do eksploracji mechanizmów generujących objawy psychotyczne (głównie w zakresie paranoi) oraz poznania i funkcjonowania społecznego (badania z użyciem wirtualnych awatarów) u osób z diagnozą psychozy nieafektywnej. Uwzględnione badania zostały przez autorów przyporządkowane do dwóch kategorii w zależności od ich rodzaju i związanego z nim poziomu wiarygodności wyników. Ponadto omówione zostały aspekty technologiczne VR z uwzględnieniem najważniejszych sposobów jej prezentowania, różnice między technologią VR a klasycznymi testami neuropoznawczymi oraz wykorzystanie tej technologii do celów diagnostycznych. W zakresie leczenia zaburzeń psychotycznych omówiono interwencje VR nakierowane w przeważającej mierze na urojenia i halucynacje słuchowe. Na koniec omówione zostały perspektywy dalszego rozwoju i wykorzystania technologii VR w psychiatrii.
Współ-powiedzenie… O funkcji wielokropka w języku ogólnym i w poezji Bolesława Leśmiana
Authors: Zaucha Joanna
Published: May 2020

CO-SAYING. ON THE FUNCTION OF ELLIPSIS IN GENERAL POLISH, AND IN BOLESŁAW LEŚMIAN’S POETRY

The goal of the paper is to identify the function of ellipsis in general Polish, and in Bolesław Leśmian’s poetry. This author assumes that ellipsis corresponds to a specific intonation, has a code character, and belongs to the group of dialogic perspective operators (cf. Wajszczuk 2005). Its function is simply an appeal to the addressee, to complete the utterance with specific content by themselves. The unit is used creatively by Bolesław Leśmian. In his poetry, co-saying serves to express the transcendence of three boundaries set by the oppositions I : you, here : there, yes : no.
Formacje z sufiksem -s typu normals, terytorials, totals
Authors: Mycawka Mirosława
Published: May 2020

FORMATIONS WITH THE -S SUFFIX: NORMALS, TERYTORIALS, TOTALS

In recent years, there appeared in Polish a series of words ending in -als. One of them is the word millennials, a lexical borrowing from English, which has been depluralized in Polish and is represented by the forms millennials – milllennialsi. Other words with a similar structure include lokals, normals, naturals, specjals, terytorials, totals. A part of them have arisen as a result of word-formation with the English suffix -s. The paper contains an analysis of these words, and attempts to answer the question how these words were created, and in what meanings they function in contemporary Polish.
Warianty morfologiczne czasownika "być" w mowie mieszkańców Spisza na podstawie danych korpusowych
Authors: Grochola-Szczepanek Helena
Published: May 2020

MORPHOLOGICAL VARIANTS OF THE VERB BYĆ ‘TO BE’ IN THE SPEECH OF THE INHABITANTS OF SPISZ: BASED ON CORPUS DATA

The article discusses the morphological differences in the verb być ‘to be’ in the Spisz dialect. The material has been excerpted from the Spisz Dialect Corpus.The author presents the characteristic forms, and extracts from them the different types of inflection, while providing the number of occurrences of all of the forms in the corpus. Selected examples are presented in a broader context together with metadata. The author also presents the possibilities opened by the use of an electronic corpus in morphological and sociolinguistic research.Verbal inflection in the Spisz dialect differs from the standard variety of Polish. Archaic forms such as byłech, jestech are still used in the dialect. Analytic variants such as ja był, my są are restricted to older respondents. Compositions such as w sklepie.m był or ja jech był are also characteristic for the older generation. Short variants like bem, bes are used in the future tense. The occurrence of the ending -me or -my in the first person plural is geographically limited.
Distribuição, evolução e produção científica dos grupos de pesquisa em atividade física e saúde do Brasil
Authors: Santos Amanda , Bastos Letícia Lemos Ayres da Gama , Aleixo Andrezza Aparecida , Paulo Thaís Reis Silva de , Mendes Edmar Lacerda
Published: May 2020

O presente estudo objetivou verificar a distribuição geográfica, evolução e produção científica dos Grupos de Pesquisa em Atividade Física e Saúde (GPAFS) no Brasil. Realizou- -se busca sistemática na base corrente e nos censos do Diretório de Grupos de Pesquisa do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), utilizando a frase exata “Atividade Física e Saúde” e Ciências da Saúde como filtro. Foram encontrados 141 GPAFS. A produção científica dos grupos foi obtida pela análise do Currículo Lattes de seus líderes. Analisaram-se os Censos a partir do ano 2000, segundo o ano de formação dos GPAFS. Divididos geograficamente, 24,82% dos GPAFS situam-se na região Sudeste, 38,30% Sul, 23,40% Nordeste, 5,67% Norte e 7,80% Centro-Oeste. Segundo a localização e a produção dos líderes, temos respectivamente, 23,02% e 32,70% no Sudeste, 34,67% e 37,10% Sul, 25,28% e 21,32% Nordeste, 6,95% e 2,36% Norte e 10,08% e 6,52% Centro-Oeste. Quanto ao período de formação, 9,93% dos GPAFS surgiram entre 2000 e 2002, 8,51% entre 2002 e 2004, 15,60% entre 2004 e 2006, 17,73% entre 2006 e 2008 e 19,86% entre 2008 e 2010. Das seis grandes áreas da saúde que estudam o tema, 72,34% dos GPAFS pertencem a Educação Física. Os dados apresentam discrepância do número de GPAFS, principalmente em relação às regiões Centro-Oeste e Norte, além da concentração da produção científica no eixo Sul-Sudeste. Políticas de incentivo à formação de jovens mestres e doutores devem ser estimuladas de forma igualitária no Brasil a fim de suprir as desigualdades entre as regiões.
Performance com bebês: deitar e rolar
Authors: Paixão Fernanda
Published: May 2020

Este texto é umrelatode experiência da prática performativa que realizei no âmbito de minha pesquisa de mestrado na Universidade Federal do Estado do Rio de Janeiro com um grupo de adultos e bebês. A prática abordou os aspectos relacionais da linguagem da performance e os desafios da comunicação inter-geracional, verbal e pré-verbal.
Role of oxygen in wound healing
Authors: Younis Ibby
Published: May 2020

Not only does oxygen play an essential role in each stage of the wound healing process. It also helps to increases host resistance to infection. Any impairment to the oxygen supply can therefore delay healing. This article explores the affects of oxygen on the wound cells and tissue, and explains how an adequate supply is required for granulation tissue formation and epithelialisation to occur
Risk management in Scottish charities: hidden practices and improvement needs in public service partnerships
Authors: Karlsson Paula Sonja , Valkama Pekka , Asenova Darinka
Published: May 2020

This study reviews the evolving role and state of risk management in Scottish charities between 2009 and 2018, with a specific focus on charities engaging in public service partnerships. It draws on data from questionnaires, interviews and charity documents. It identifies how risk management activities are organised in the Scottish charity sector in general. It also identifies how charities deal with risk in partnerships. The findings suggest that most risk management activities are implicit and sporadic, with some Scottish charities engaging in more formal practices, although none of the risk management activities extend to partnership working and reporting on risk management practices is also limited.
Governmental social work (part 2): three dimensions of governmental social work
Authors: Harris John , Shergill Makhan
Published: May 2020

A previous article considered a new ‘settlement’ for social work and social work education through a critical discourse analysis of Putting children first (Department for Education, 2016). This was treated as the foundational text of what was designated ‘governmental social work’. Here, three dimensions of governmental social work are identified in Putting children first: enactment – changed ways of acting and interacting; inculcation – changed beliefs and ways of being; and materialisation – changes in organisations and structures. These three dimensions suggest the ways in which the transformative strategy of governmental social work seeks to achieve outcomes or objectives within existing structures and practices and, especially, by changing them in particular ways. Being seen as a progressive social worker involves the acceptance of and involvement in governmental social work’s changed practices, beliefs and institutional frameworks.
Optical bistability of partial reflection-coated thin film of oil red O
Authors: Ho Quang Quy , Mai Van Luu , Thai Doan Thanh , Bui Xuan Kien , Nguyen Manh Thang , Ho Dinh Quang
Published: May 2020

In this paper, a thin film of oil red O coated by partial dielectric mirrors (PRFORO) operating as an optical bistable device is proposed. The equation of the output–input intensity relation considering nonlinear absorption inside PRFORO is derived and the optical bistability (OB) of PRFORO is shown. Additionally, the influence of the nonlinear refractive, absorptive coefficients of oil red O (ORO), reflective coefficient of mirrors, and the thickness of thin film on the OB is numerically investigated and discussed. As a result, the threshold switching power is lower than 19 mW; the minimum power of output up-state is larger than 40 µW for the optimal PRFORO designed with an ORO concentration larger than 0.1 mM; the thickness of the thin film is longer than 0.1 mm; and the reflective coefficient of mirrors is lower than 93%. The proposed model is suitable for all-optical switches, optical images, and signal processing.
Enhanced principle component method for fringe removal in cold atom images
Authors: Xiong Feng , Long Yun , Parker Colin V.
Published: May 2020

Many powerful imaging techniques for cold atoms are based on
determining the optical density by comparing a beam image having
passed through the atom cloud to a reference image taken under similar
conditions with no atoms. In practice, the beam profile typically
contains interference fringes whose phase is not stable between camera
exposures. To reduce the error of these fringes in the computed
optical density, an algorithm based on principle component analysis
(PCA) is often employed. However, PCA is general purpose and not
tailored to the specific case of interference fringes. Here we
demonstrate an algorithm that takes advantage of the Fourier space
structure of interference fringes to further reduce the residual
fringe signatures in the optical density.
Quantification of nonlocal dispersion cancellation for finite frequency entanglement
Authors: Xiang Xiao , Dong Ruifang , Li Baihong , Hou Feiyan , Quan Runai , Liu Tao , Zhang Shougang
Published: May 2020

Benefiting from the unique quantum feature of nonlocal dispersion cancellation (NDC), the strong temporal correlation of frequency-entangled photon pair source can be maintained from the unavoidable dispersive propagation. It has thus played a major role in many fiber-based quantum information applications. However, the limit of NDC due to finite frequency entanglement has not been quantified. In this study, we provide a full theoretical analysis of the NDC characteristics for the photon pairs with finite frequency entanglement. Experimental examinations were conducted by using two spontaneous parametric down-conversion photon pair sources with frequency correlation and anticorrelation properties. The excellent agreement demonstrates the fundamental limit on the minimum temporal correlation width by the nonzero two-photon spectral correlation width of the paired photons, which introduces an inevitable broadening by interaction with the dispersion in the signal path. This study provides an easily accessible tool for assessing and optimizing the NDC in various quantum information applications.
Compressive ghost imaging through scattering media with deep learning
Authors: Li Fengqiang , Zhao Ming , Tian Zhiming , Willomitzer Florian , Cossairt Oliver
Published: May 2020

Imaging through scattering media is challenging since the signal to noise ratio (SNR) of the reflection can be heavily reduced by scatterers. Single-pixel detectors (SPD) with high sensitivities offer compelling advantages for sensing such weak signals. In this paper, we focus on the use of ghost imaging to resolve 2D spatial information using just an SPD. We prototype a polarimetric ghost imaging system that suppresses backscattering from volumetric media and leverages deep learning for fast reconstructions. In this work, we implement ghost imaging by projecting Hadamard patterns that are optimized for imaging through scattering media. We demonstrate good quality reconstructions in highly scattering conditions using a 1.6% sampling rate.
Tunable in the range of 4.5-6.8 µm room temperature single-crystal Fe:CdTe laser pumped by Fe:ZnSe laser
Authors: Frolov Mikhail P. , Korostelin Yuri V. , Kozlovsky Vladimir I. , Leonov Stanislav O. , Skasyrsky Yan K.
Published: May 2020

We report a laser operation from a Fe:CdTe single crystal, pumped by 40-ns pulses of a 4.12-µm Fe:ZnSe laser. The maximum output energy of 5.8 mJ was produced at 5.4 µm with 30% absorbed energy slope efficiency. A record 2300-nm-wide smooth and continuous wavelength tunability over 4.5-6.8 µm range was demonstrated, being the longest wavelength tuning achieved for Fe2+-doped chalcogenide lasers. We also discuss the features of the oscillation spectra.
Ultralow-quantum-defect Raman laser based on the boson peak in phosphosilicate fiber
Authors: Zhang Yang , Xu Jiangming , Ye Jun , Song Jiaxin , Yao Tianfu , Zhou Pu
Published: May 2020

Quantum defects (QDs) have always been a key factor of the thermal effect in high-power fiber lasers. Much research on low-QD fiber lasers has been reported in the past decades, but most of it is based on active fibers. Besides, Raman fiber lasers based on the stimulated Raman scattering effect in passive fiber are also becoming an important kind of high-power fiber laser for their unique advantages, such as their significantly broader wavelength-tuning range and being free of photon darkening. In this paper, we demonstrate an ultralow-QD Raman fiber laser based on phosphosilicate fiber. There is a strong boson peak located at a frequency shift of 3.65 THz in the Raman gain spectrum of the phosphosilicate fiber we employed. By utilizing this boson peak to provide Raman gain and adopting an amplified spontaneous emission source at 1066 nm as the pump source, 1080 nm Stokes light is generated, corresponding to a QD of 1.3%. The spectral purity at 1080 nm can be up to 96.03%, and the output power is 12.5 W, corresponding to a conversion efficiency of 67.2%. Moreover, by increasing the pump wavelength to 1072 nm, the QD is reduced to 0.74%, and the output power at 1080 nm is 10.7 W, with a spectral purity of 82.82%. To the best of our knowledge, this is the lowest QD ever reported for Raman fiber lasers. This work proposes a promising way of achieving high-power, high-efficiency Raman fiber lasers.
Subwavelength thick ultrahigh-Q terahertz disc microresonators
Authors: Vogt Dominik Walter , Jones Angus Harvey , Haase Thomas Alan , Leonhardt Rainer
Published: May 2020

Artificial structures that exhibit narrow resonance features are key to a myriad of scientific advances and technologies. In particular, exploration of the terahertz (THz) spectrum—the final frontier of the electromagnetic spectrum—would greatly benefit from high-quality resonant structures. Here we present a new paradigm of terahertz silicon disc microresonators with subwavelength thickness. Experimental results utilizing continuous-wave THz spectroscopy establish quality factors in excess of 120,000 at 0.6 THz. Reduction of the disc thickness to a fraction of the wavelength reduces the losses from the silicon substrate and paves the way to unparalleled possibilities for light–matter interaction in the THz frequency range.
Transcranial Photobiomodulation Recipients Present Information Flow Alterations from the Site of Stimulation: a Granger Causality Analysis
Authors: Pruitt Tyrell , Wang Xinlong , Liu Hanli
Published: May 2020

The effects of tPBM on the brain are still unknown. This study has conducted a Granger based information flow analysis on tPBM data to uncover changes in information flow which were seen in delta/beta bands.
Through the Black Mirror: Discourses on gender and technology in popular culture
Authors: Modugno Chiara , Krijnen Tonny
Published: May 2020

Technology’s place in society is increasingly significant and debated. Although the inclusion of gender in discussions about technology is not novel, striking examples such as sexism (and racism) in artificial intelligence underscore the urgency of the debate. Popular sci-fi TV forms an important arena for the meaning-making on gender and technology for its audiences. Going beyond ‘gender essentialism’ and ‘technological determinism’, this study investigates gender and technology as represented in Black Mirror. As an anthology series, Black Mirror presents its audiences recognizable technologies and a diverse cast (in terms of gender and race). Employing a mixture of narrative and discourse analysis on all episodes of Black Mirror, how discourses on technology are gendered in Black Mirror is unravelled. Two dominant discourses – the Spectacle and the New Social Contract – show that beyond a manifest gender neutrality of technology, on a latent level patriarchal discourses are dominant in imagined future societies.
The Sculptor and the Professor: Two ages of objectification by the film spectator
Authors: Balakrishnan Vinod , Asokan Ponnamma Anupama
Published: May 2020

A paradigm shift has happened in the relationship between the spectator and the woman-on-the-screen. The shift from an analogue to a digital era implies that the dynamics of objectification have also shifted irrevocably. The two ages of voyeurism are characterized, respectively, through Hitchcock’s Rear Window (1954) and Alex Garland’s Ex Machina (2014). The paper reads that the voyeur in the analogue frame of Rear Window (Jeff) is in a metaphoric relationship with the women-through-his-lens while the spectator – post-2013-drawing from an archive of pornography is in a synecdochic relationship where the woman is, to invoke Shelley Jackson, a ‘Stitch Bitch’. The article posits that the telltale shift has caused a change in the materiality of the woman which has, technologically, gravitated from a celluloid frame to an algorithmic reconstitution. It means, in the digital era, the spectator–voyeur’s relationship with and the objectification of the woman has been reset: From Pin-up to the Patchwork girl.
Debates about the generic ontology of film noir
Authors: Varmazi Eleni , Kaya Funda
Published: May 2020

This viewpoint discusses the various definitions given to classic film noir in order to show how the concept of film noir is difficult to demarcate as a genre, remaining a debatable subject among theoreticians. On a broader level, it might be argued that these discussions are linked with the intertextuality, the dynamism and the hybridity of film genres. One can also argue that film noir stands as one of the preliminary examples of such hybridity in the history of Western narrative cinema. Such a debate is also connected to film noir’s deviance from Hollywood conventions. While inhabiting elements from these conventions, classic noir has been affected by European film movements whilst influencing them. Noir holds a critical position to the social conditions of its era, defined usually from the early 1940s to the late 1950s. It also produces generic stereotypical characters such as the ‘hardboiled’ detective and the femme fatale that are both embraced and highly criticized by film theoreticians. However, film noir is an ambivalent concept, a category of films that can be sensed, yet resists delimitation within strict boundaries.
Usos políticos de la metáfora. Medios, instituciones y ciudadanía en la definición de conflictos en la esfera pública, A. Capdevila Gómez and C. Moragas-Fernández (eds) (2019)
Authors: Gómez Carmen González
Published: May 2020

Review of: Usos políticos de la metáfora. Medios, instituciones y ciudadanía en la definición de conflictos en la esfera pública, A. Capdevila Gómez and C. Moragas-Fernández (eds) (2019)

Barcelona: Icaria, 184 pp.,

ISBN 978-8-49888-931-4, p/bk, €18
Showing the way, or getting in the way? Discussing power, influence and intervention in contemporary musical-social practices
Authors: Ansdell Gary , Brøske Brit Ågot , Black Pauline , Lee Sara
Published: May 2020

This article presents a broad discussion of power and influence within contemporary participatory music practices in relation to practices of intervention. The discussion is presented through the respective experience and professional perspectives of music therapy, music education and community music – each illustrated by current practice examples and their accompanying dilemmas; and covering both local and international projects. In a shared closing discussion, the four authors review the key question: whether professional influence and power in participatory music practices ‘shows the way’ or ‘gets in the way’. They conclude that intervention takes place on a continuum, in different ways, and to different degrees and levels. What is vital is to retain practical and ethical reflexivity on the dimensions of intervention as a practice that can offer both creative opportunities, but which can also be part of subtly oppressive power relationships.
Capturing the magic: A three-way dialogue on the impact of music on people and society
Authors: Camlin Dave , Caulfield Laura , Perkins Rosie
Published: May 2020

This article sets out a dialogue on the impact of music on people and society. The perspectives of three researchers, from different experiential and methodological backgrounds, are presented. The article explores: how we define concepts of impact; how we seek to measure the impact of engaging with music, providing examples from our own recent work; and tensions in attempting to capture or measure the ‘magic’ of music, including how to meet the needs of different audiences and how to develop new ways to capture impact. The authors reflect on the political climate in which music interventions operate, including the need to ask different questions at different times for different audiences, concluding that it is vital to measure both whether there is any impact, how this impact was achieved, and people’s experiences of engaging with music. We found consensus about the need to move evidence forwards through both the use of arts-based creative methods that focus on the music-making process itself as well as through collaborations that bring together varied perspectives, experiences, disciplines and research methods. We also argue that – as there is considerable evidence about the impact of music, on different people, in different ways and in different settings – researchers should now aim to take stock of the evidence base. Finally, we posit that there is merit in engaging with a reflective dialogue like the one presented here, as a tool to help challenge, disrupt and influence our own thinking.
How The Pink Panther came alive and how The Thin Man grew fatter: Hungry franchises and the adaptation industry
Authors: Schwanebeck Wieland
Published: May 2020

While entertainment franchises are usually not associated with engaging in adaptive work in the traditional sense of the term, the sheer necessity of creating new material for serialised properties makes adaptive work a necessity. Frequently, franchises will absorb other material, an aspect that has so far been neglected in studies of what Simone Murray calls the ‘adaptation industry’. This article discusses two entertainment properties that made a habit of lapping up cinematic trends and other properties in order to feed their appetite as ‘hungry franchises’: the Thin Man series (1934–47) and the Pink Panther films (1963–2009). They exhibit similar adaptive strategies to reconcile contemporary audience expectations and industrial trends with their needs as profitable studio properties. In the process, they also show somewhat Frankenstein-like tendencies towards monstrosity, eventually turning against their own creators.
Shakespearean Celebrity in the Digital Age: Fan Cultures and Remediation, Anna Blackwell (2018)
Authors: Compagnoni Michela
Published: May 2020

Review of: Shakespearean Celebrity in the Digital Age: Fan Cultures and Remediation, Anna Blackwell (2018)

Basingstoke: Palgrave Macmillan, xiii + 188 pp.,

ISBN 978-3-31996-543-7, h/bk, €72.79, p/bk, €51.99;

ISBN 978-3-31996-544-4, e/bk, €42.79
‘La voz del pueblo y para el pueblo’ Amparo Ochoa’s vocal trajectory: From the Mexican Revolution to the Latin American Cold War
Authors: Bieletto-Bueno Natalia
Published: May 2020

Amparo Ochoa (29 September 1946–7 February 1994) is widely acclaimed as one the most outstanding and versatile performers of the Mexican Canto Nuevo movement. The sympathy that Amparo Ochoa awoke among Mexican and Latin American audiences has been tacitly attributed to a sort of natural charm. Therefore, a supposedly ‘popular’ character within her voice has been substantiated as a result of the political message of the songs she interpreted as well as of the forums where she publicly appeared. Complementing the reiterative focus on either the political context or the discursive elements of the Canto Nuevo, this paper historicizes Ochoa’s trajectory, problematizing notions of ‘the people’ in order to dissect ‘the popular’ within her voice. The main claim is that the general reception of her voice as the voice of ‘the people’ is grounded on firm vocal traditions of turn of the twentieth century Mexican musical theatre, which lingered to the twentieth century but which were recontextualized during the Latin American Cold War. Due to its subjective impact on the listener, these vocal strategies made audiences subjectify notions of ‘el pueblo’ and thus garner sympathies for the movements that opposed dictatorial regimes during the 1970s and 1980s. Such an approach of her voice contributes to assess the role of music and song in the ideological and political projects that framed them as well as to question the affective impact of voice in the listener’s subjectivity.
‘A series of images against you and me’: Richey Edwards’ portrayal of the body in Journal For Plague Lovers
Authors: Mankowski Guy
Published: May 2020

‘It is at the level of the body that we proceed’ (David Foster Wallace, The Pale King). Although there has been critical analysis of Richey Edwards’ lyrics on the post-punk album The Holy Bible, there has been little analysis of his final published lyrics from the folder that Edwards left prior to his disappearance, as used for the 2009 album Journal For Plague Lovers (JFPL). As Wodkte (2016) states in her chapter in Triptych: Three Studies of Manic Street Preachers’ The Holy Bible, ‘JFPL uses the body and skin as texts of difficult knowledge and abjection’. Over the course of JFPL’s lyrics, the human form is dissected, distorted and eventually the physical envelope is ruptured. The narrative offered by each album track is considered in order to examine this. This article expands on the small number of previous analyses of Edwards’ lyrics in two ways: (1) it contrasts JFPL to Giacomo model for understanding modes of artistic output (considering textscapes, soundscapes and landscapes); and (2) this article builds on applications of Greenblatt’s (1983) concept of ‘self-fashioning’ in relation to JFPL. The article concludes that in Edwards’ lyrics, a number of metaphors reconfigure the malleability of the physical body and expand the concept of how self-fashioning can be applied in relation to it.
Pibid e formação docente: contribuições do professor supervisor
Authors: Queiroz Elaine de Oliveira Carvalho Moral , Andrade Maria de Fátima Ramos , Mizukami Maria da Graça Nicoletti
Published: May 2020

O presente artigo tem por objetivo analisar contribuições do professor supervisor para a prática pedagógica do aluno egresso do curso de Pedagogia e em início de carreira que tenha participado do Programa Institucional de Bolsa de Iniciação à Docência (PIBID). Tratou-se de uma pesquisa de cunho qualitativo, tendo como instrumentos de coleta de dados um formulário fechado e entrevistas semiestruturadas, além da análise de documentos oficiais. O referencial teórico pautou-se em autores da pedagogia crítica e em estudos sobre os saberes docentes, a relação teoria e prática e a formação docente. Constatamos que, a partir das ações dos supervisores junto aos alunos bolsistas participantes do PIBID, estabeleceu-se uma parceria entre a universidade e as escolas da rede pública, beneficiando a formação dos licenciandos para atuarem na docência.
Allogenic Fecal Microbiota Transplantation in Patients With Nonalcoholic Fatty Liver Disease Improves Abnormal Small Intestinal Permeability: A Randomized Control Trial
Authors: Craven Laura , Rahman Adam , Nair Parvathy Seema , Beaton Melanie , Silverman Justin , Qumosani Karim , Hramiak Irene , Hegele Rob , Joy Tisha , Meddings Jon , Urquhart Brad , Harvie Ruth , McKenzie Charles , Summers Kelly , Reid Gregor , Burton Jeremy P. , Silverman Michael
Published: May 2020

INTRODUCTION:

Nonalcoholic fatty liver disease (NAFLD) is an obesity-related disorder that is rapidly increasing in incidence and is considered the hepatic manifestation of the metabolic syndrome. The gut microbiome plays a role in metabolism and maintaining gut barrier integrity. Studies have found differences in the microbiota between NAFLD and healthy patients and increased intestinal permeability in patients with NAFLD. Fecal microbiota transplantation (FMT) can be used to alter the gut microbiome. It was hypothesized that an FMT from a thin and healthy donor given to patients with NAFLD would improve insulin resistance (IR), hepatic proton density fat fraction (PDFF), and intestinal permeability.

METHODS:

Twenty-one patients with NAFLD were recruited and randomized in a ratio of 3:1 to either an allogenic (n = 15) or an autologous (n = 6) FMT delivered by using an endoscope to the distal duodenum. IR was calculated by HOMA-IR, hepatic PDFF was measured by MRI, and intestinal permeability was tested using the lactulose:mannitol urine test. Additional markers of metabolic syndrome and the gut microbiota were examined. Patient visits occurred at baseline, 2, 6 weeks, and 6 months post-FMT.

RESULTS:

There were no significant changes in HOMA-IR or hepatic PDFF in patients who received the allogenic or autologous FMT. Allogenic FMT patients with elevated small intestinal permeability (>0.025 lactulose:mannitol, n = 7) at baseline had a significant reduction 6 weeks after allogenic FMT.

DISCUSSION:

FMT did not improve IR as measured by HOMA-IR or hepatic PDFF but did have the potential to reduce small intestinal permeability in patients with NAFLD.
Hepatoid Adenocarcinoma Presenting as Pancreatitis
Authors: Chaudhari Rahul , Murphy Katherine , Schwartz Stephen , Chaudhari Jigisha , Ho Immanuel , Nunes Frederick
Published: May 2020

Hepatoid adenocarcinoma (HAC) is an uncommon and aggressive type of adenocarcinoma, typically affecting the middle-aged and elderly. The morphological features of the HAC resemble hepatocellular carcinoma. Presenting symptoms may include upper abdominal pain, hematemesis, back pain, and palpable abdominal mass. HAC has no proven therapy, and the prognosis is extremely poor. Early surgical removal with chemotherapy remains the standard of care. We describe one of the youngest patients in the literature with HAC who presented with acute pancreatitis. The diagnostic workup was confused by diffuse lymphadenopathy and elevated β-human chorionic gonadotropin making lymphoma and germ cell tumor likely possibilities until immunohistochemistry confirmed the diagnosis.
Fecal Calprotectin Predicts Mucosal Healing in Patients With Ulcerative Colitis Treated With Biological Therapies: A Prospective Study
Authors: Bertani Lorenzo , Blandizzi Corrado , Mumolo Maria Gloria , Ceccarelli Linda , Albano Eleonora , Tapete Gherardo , Baiano Svizzero Giovanni , Zanzi Federico , Coppini Francesca , de Bortoli Nicola , Bellini Massimo , Morganti Riccardo , Marchi Santino , Costa Francesco
Published: May 2020

INTRODUCTION:

Biological therapies are widely used for the treatment of ulcerative colitis. However, only a low proportion of patients achieve clinical remission and even less mucosal healing. There is currently scarce knowledge about the early markers of therapeutic response, with particular regard to mucosal healing. The aim of this prospective study was to evaluate the role of fecal calprotectin (FC) as early predictor of mucosal healing.

METHODS:

A prospective observational study was conducted on patients with ulcerative colitis, who started biological therapy with infliximab, adalimumab, golimumab, or vedolizumab at our center. All patients underwent colonoscopy, performed by 2 blinded operators, at baseline and week 54 or in case of therapy discontinuation because of loss of response. FC was assessed at baseline and week 8 and evaluated as putative predictor of mucosal healing at week 54.

RESULTS:

We enrolled 109 patients, and 97 were included in the analysis. Twenty-six patients (27%) experienced loss of response. Over 71 patients (73%) with clinical response at week 54, clinical remission was obtained in 60 patients (61.9%) and mucosal healing in 45 patients (46.4%). After 8 weeks of treatment, FC predicted mucosal healing at week 54 (P < 0.0001). Sensitivity, specificity, positive predictive value, and negative predictive value were estimated to be 75%, 88.9%, 86.6%, and 75.5%, respectively, based on a cutoff of 157.5 mg/kg.

DISCUSSION:

The present study suggests that FC assessment after 8 weeks of treatment with all the biological drugs could represent a promising early marker of response to therapy in terms of mucosal healing.
Open Badges for Employee Skill Tracking
Authors: Clements Kyle , Jackson Sam , West Richard E.
Published: May 2020

This case explores the creation of an open badge student-employee training program. Utilizing competency-based learning, we created nearly 40 digital credentials for technical skills related to various software products. We specifically share the decisions we made related to the process of defining competencies, formatting badge criteria, and building a flexible learning system. We also discuss various challenges, including how we motivated employees to participate in the program and unforeseen challenges related to selecting a badge issuing tool.
Designing a Digital Roleplaying Game to Foster Awareness of Hidden Disabilities
Authors: Da Silva Rafael Leonardo
Published: May 2020

On Fighting Shadows (OFS) is a two-dimensional roleplaying game that tells the story of Marvin, a young adult that experiences hidden disabilities, focusing on hydrocephalus and its possible mental health implications, such as anxiety and depression. Developed with the goal of being both informational and engaging, OFS aims to increase awareness and foster discussions not only about hidden disabilities as medical conditions, but also as phenomena that are experienced in society. The objective of this design case is to describe the development process, including the design dilemmas, of the prototype of OFS, as well as to discuss future directions of this project. Both in the prototype design phase and in usability testing, the tension between learning and entertainment was observed, aligning with reflections from previous studies (Prestopnik, 2016). Playing OFS was also observed to engage users in experiencing symptoms of hydrocephalus and understanding the character’s feelings. Possible directions to improve the experience for different user profiles involve adaptation of game conditions for players that would like to prioritize educational information over fun, and vice-versa.
Stabilitas Hemodinamik Propofol – Ketamin Vs Propofol – Fentanyl pada Operasi Sterilisasi / Ligasi Tuba
Authors: Prasetya Laurentius Sandhie , Sudadi Sudadi
Published: May 2020

Latar belakang: Teknik TIVA kontinyu menggunakan kombinasi propofol dan fentanyl telah umum digunakan. Teknik tersebut dapat memberikan anestesi yang adekuat, namun dapat menyebabkan perubahan hemodinamik durante operatif yang bervariasi. Kombinasi propofol dan ketamin diharapkan dapat memberikan anestesi yang nyaman untuk pembedahan dengan perubahan hemodinamik durante operatif yang lebih stabil.Metode: Desain penelitian percobaan acak terkontrol. Ruang lingkup penelitian adalah pasien wanita yang menjalani operasi sterilisasi ligasi tuba dengan Metode Operasi Wanita dengan tehnik anestesi TIVA kontinyu. Subyek berjumlah 70 yang memenuhi kriteria inklusi, dibagi menjadi dua kelompok yang masing -masing terdiri dari 35. Kelompok PK adalah subyek yang menggunakan kombinasi propofol 2 mg/kgbb dan ketamin 0,5 mg/kgbb dilanjutkan pemeliharaan propofol 2 mg/kgbb/jam dan ketamin 0,5 mg/kgbb/jam intravena, sedangkan kelompok PF adalah subyek yang menggunakan kombinasi induksi propofol 2 mg/kgbb dan fentanyl 1 μg/kgbb dilanjutkan pemeliharaan propofol 2 mg/kgbb/jam dan fentanyl 1 μg/kgbb/jam intravena. Penilaian parameter perubahan hemodinamik meliputi tekanan darah sistolik (TDS), tekanan arteri rerata (TAR) dan laju denyut jantung (DJ) dinilai pada saat induksi, insisi dan durante operasi hingga selesai.Hasil: Penurunan parameter hemodinamik lebih dari 10 % terjadi pada kelompok PF pada saat induksi, insisi dan menit ke-5, dimana tekanan darah sistolik (TDS) menurun sebesar 15,5 (7,26) %, tekanan arteri rerata (TAR) menurun sebesar 14,0 (8,34) % dan laju denyut jantung (DJ) sebesar 14,2 (6,52) % sedangkan pada kelompok PK terjadi penurunan TDS sebesar 4,3 (2,72) % (p = 0,000), TAR of 4,6 (3,18) % (p =0,000) dan DJ sebesar 3,5(2,63) % (p = 0,000) saat induksi.Simpulan: Stabilitas hemodinamik kelompok PK lebih baik daripada kelompok PF.
Pengaruh Anestesi Regional dan General pada Sectio Cesaria pada Ibu dengan Pre Eklampsia Berat terhadap Apgar Score
Authors: Wijayanto Nurhadi , Leksana Ery , Budiono Uripno
Published: May 2020

Latar belakang : pada pasien preeklampsia berat intubasi merupakan tindakan yang berbahaya karena berkaitan dengan menejeman jalan napas dan gejolak hemodinamik yang mungkin terjadi. Anestesi spinal banyak dihindari berkaitan dengan resiko hipotensinya namun beberapa penelitian telah menunjukkan bahwa anestesi spinal adalah aman bagi ibu maupun janin . perdebatan tentang pengaruh anestesi umum dan anestesi spinal terhadap Apgar score adalah sesuatu yang menarik. Beberapa penelitian menunjukkan bahwa tidak ada perbedaan anestesi pada keduanya namun pada penelitian lainnya dikatakan bahwa dengan apresiasi umum akan menghasilkan anestesi yang lebih rendah daripada anestesi spinal.Tujuan : untuk membandingkan pengaruh anestesi umum dan anestesi spinal terhadap anak yang dilahirkan oleh ibu dengan sectio caesaria karena preeklampsia berat.Metode : merupakan penelitian eksperimental dengan desain penelitian prospective randomized control trial, kelompok penelitian dibagi menjadi dua (n:8), kelompok I merupakan kelompok yang mendapat anestesi umum dengan pentothal dosis 5mg/bb dan pelumpuh otot suksinilkholis dosis 1.5mg/bbKesimpulan : Apgar score pada kelompok anesthesi spinal lebih tinggi daripada anestesi umum pada pasien sectio caesaria karena preeklampsia berat, tetapi secara klinis berdasarkan kategori Apgar score kedua kelompok sama