bluuebunny/crossref_metadata_2025 huggingface dataset:
Accessory mental foramina and nerves: Application to periodontal, periapical, and implant surgery
Authors: Iwanaga Joe , Watanabe Koichi , Saga Tsuyoshi , Tabira Yoko , Kitashima Sadaharu , Kusukawa Jingo , Yamaki Koh‐Ichi
Published: September 2015

Recent studies investigating accessory mental foramina using developments in diagnostic imaging have primarily defined the morphology of the foramina; however, few studies have described the structures passing through them. Additional clinical knowledge of the foramina is therefore required for preoperative diagnosis prior to surgery, including implant, periodontal and periapical surgery. In this study, we investigated the accessory mental foramina and the associated nerves and arteries in donated cadaveric mandibles using anatomical and radiological observation methods. We examined 63 mandibles with overlying soft tissue by cone‐beam computed tomography and noted the existence of the accessory mental foramina. Mandibles with accessory mental foramina were subsequently analyzed. Additionally, the neurovascular bundles passing through these foramina were dissected using anatomical methods.The incidence of accessory mental foramina was 14.3%. The larger foramina tended to be located anteriorly or superiorly and proximal to the mental foramen, while the smaller foramina tended to be located posterosuperiorly and distal to the mental foramen. The mental foramen ipsilateral to the accessory mental foramen was smaller than the one contralateral to it. The comparatively distant and large accessory mental foramen included an artery.This study elucidated the relationship between accessory mental foramina and the associated nerves and arteries. We believe that the results will contribute to the clinical dentistry field. Clin. Anat. 29:493–501, 2016. © 2015 Wiley Periodicals, Inc.
Tools and methodologies for teaching robotics in computer science & engineering studies
Authors: Berenguel Manuel , Rodríguez Francisco , Moreno José Carlos , Guzmán José Luis , González Ramón
Published: September 2015

This work presents a teaching experience of Robotics in Computer Science & Engineering studies at the University of Almería (Spain). The teaching methodology is mainly based on the use of ICT. In particular, interactive software tools, virtual and remote laboratories, and an e‐learning content management are used. Such technologies have significantly helped to improve the learning ability of the students. A discussion and feedback from students are presented to show the result of this educational approach. © 2015 Wiley Periodicals, Inc. Comput Appl Eng Educ 24:202–214, 2016; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21698
The perilipin‐2 (adipophilin) coat of cytosolic lipid droplets is regulated by an Arf1‐dependent mechanism in HC11 mouse mammary epithelial cells
Authors: Pauloin Alain , Adenot Pierre , Hue‐Beauvais Catherine , Chanat Eric
Published: September 2015

The cytosolic lipid droplets (cLDs) store excess intracellular lipids, and perilipin‐2 is believed to protect cLDs from degradation. Here, we investigated the role of the small G‐protein Arf1 and the proteasome in the fates of perilipin‐2 and cLDs. In oleate‐loaded cells, upon brefeldin A (BFA) treatment, perilipin‐2 remained associated with cLDs for at least 30 min before significant release, and proteasomal degradation‐mediated decrease was observed. Interestingly, the cLD population did not mimic the decline in perilipin‐2. We tested several chemical modulators of regulators of Arf1 activity on the association of perilipin‐2 with cLDs. QS11 and Exo2 accelerated the reduction in perilipin‐2, although less than BFA. In contrast, Exo1 unexpectedly slowed down its degradation. Correlatively, BFA, QS11, and Exo2 enhanced the dissociation of perilipin‐2 from cLDs, whereas Exo1 inhibited it. There was a synergistic effect of BFA with Exo2 and QS11, and of Exo2 with QS11, whereas Exo1 antagonized the effect of BFA without affecting that of Exo2 or QS11. We concluded that the Arf1 complex regulates the association of perilipin‐2 with cLDs. Additionally, MG132 and BFA modified the number of cLDs over a relatively short period.
Clinical outcomes in real‐world patients with bifurcation lesions receiving Xience V everolimus‐eluting stents: Four‐year results from the Xience V USA study
Authors: Hermiller James B. , Applegate Robert J. , Baird Colleen , Butler Michael M. , Rutledge David , Wang Jin , Kakarala Kalyan , Krucoff Mitchell W. , Sudhir Krishnankutty
Published: September 2015

Background

The Xience V USA Study demonstrated safety and efficacy of the XIENCE V® everolimus‐eluting stent (EES) in a large, prospective study of a real‐world, unselected patient population. There is limited long‐term data regarding EES performance in high risk patients with bifurcation lesions (BIF). The objective of this analysis was to evaluate the long‐term safety and effectiveness of EES in patients with BIF from the XIENCE V USA study.

Methods

The Xience V USA Study was a single arm, prospective, multicenter, real‐world study (n = 5,054) undergoing PCI with EES. Baseline data and clinical outcomes at 4 years were evaluated in the subgroup of patients with ≥ 1 BIF who did not undergo a staged procedure. Co‐primary endpoints were ARC definite/probable stent thrombosis and a composite of cardiac death and ARC‐defined myocardial infarction (MI). Endpoints were adjudicated by an independent CEC.

Results

Of 4,768 patients who did not undergo a staged procedure, there were 511 (10.7%) patients with BIF and 4,257 (89.3%) patients without BIF. Follow‐up data was available in 4,459 patients (466 BIF, 3,993 non‐BIF). Through binary outcome analysis, at 1 year the overall definite/probable stent thrombosis rates were higher in the BIF group (1.84% vs. 0.76%, P = 0.03). However, at 4 years, the difference in cumulative rates of ARC definite/probable stent thrombosis (BIF 2.3% vs. non‐BIF 1.4%, P = 0.13) remained the same as that at 1 year, with no incremental definite/probable stent thrombosis in BIF patients from 2‐4 years. The 4‐year rates of composite cardiac death and MI were 13.5% for BIF vs. 14.1% for non‐BIF (P = 0.78). At 4 years, target lesion failure (19.1% vs. 18.3%, P = 0.66) and ischemia driven‐target lesion revascularization (10.2% vs. 10.1%, P = 0.89) were comparable between the two groups.

Conclusions

This subgroup analysis of BIF lesions in a real world population receiving EES demonstrates continued low rates of clinical outcomes in the BIF subgroup at 4 years with no incremental stent thrombosis increase in BIF patients from 2 to 4 years. © 2015 Wiley Periodicals, Inc.
ChemInform Abstract: Hybridization Gap and Dresselhaus Spin Splitting in EuIr4In2Ge4.
Authors: Calta Nicholas P. , Im Jino , Rodriguez Alexandra P. , Fang Lei , Bugaris Daniel E. , Chasapis Thomas C. , Freeman Arthur J. , Kanatzidis Mercouri G.
Published: September 2015

EuIr4In2Ge4 is prepared by flux melting of the elements in the molar ratio of Eu:Ir:Ge:In = 1:1:1:30 (alumina crucible in evacuated silica tubes, 1000 °C, 12 h; cooling to 550 °C over 2 d).
ChemInform Abstract: Black Arsenic—Phosphorus: Layered Anisotropic Infrared Semiconductors with Highly Tunable Compositions and Properties.
Authors: Zhou Chongwu , et al.
Published: September 2015

Black AsxP1‐x (x = 0, 0.25, 0,4) is prepared by vapor transport of a mixture of gray As and red P to which a Sn/SnCl4 mixture is given as mineralizer (evacuated silica tubes, complex heating and cooling schedules) and subsequently exfoliated for optical and electrochemical measurements.
ChemInform Abstract: Ultraviolet Photolysis Studies on XeO4 in Noble‐Gas and F2 Matrices and the Formation and Characterization of a New XeVIII Oxide, (η2‐O2)XeO3.
Authors: Vent‐Schmidt Thomas , Goettel James T. , Schrobilgen Gary J. , Riedel Sebastian
Published: September 2015

Na4Xe16O6 (I) and Xe16O4 (II) are prepared by dissolving XeF6 in H2O and adding MgO to precipitate MgF2 which is removed by centrifugation.
ChemInform Abstract: Synthesis and Surface Chemistry of High Quality Wurtzite and Kesterite Cu2ZnSnS4 Nanocrystals Using Tin(II) 2‐Ethylhexanoate as a New Tin Source.
Authors: Gabka Grzegorz , Bujak Piotr , Gryszel Maciej , Ostrowski Andrzej , Malinowska Karolina , Zukowska Grazyna Z. , Agnese Fabio , Pron Adam , Reiss Peter
Published: September 2015

A new synthesis of the title nanocrystals is reported, in which solid and difficult to dissolve precursors of tin are replaced by liquid tin(II) 2‐ethylhexanoate.
ChemInform Abstract: Organomagnesium‐Catalyzed Isomerization of Terminal Alkynes to Allenes and Internal Alkynes.
Authors: Rochat Raphael , Yamamoto Koji , Lopez Michael J. , Nagae Haruki , Tsurugi Hayato , Mashima Kazushi
Published: September 2015

The synthesis of a dimeric organomagnesium complex (MGC) is reported.
ChemInform Abstract: Intermolecular Addition Reactions of N‐Alkyl‐N‐chlorosulfonamides to Unsaturated Compounds.
Authors: Heuger Gerold , Goettlich Richard
Published: September 2015

A copper catalyzed addition of N‐chlorosulfonamides to various styrenes via amidyl radicals is presented.
ChemInform Abstract: A Simple Procedure for the Oxidation of Alcohols Using [Bis(acetoxy)iodo]benzene and a Catalytic Amount of Bromide Ions in Ethyl Acetate.
Authors: Salvo Anna Maria Pia , Campisciano Vincenzo , Beejapur Hazi Ahmad , Giacalone Francesco , Gruttadauria Michelangelo
Published: September 2015

The oxidation of primary and secondary benzylic alcohols to the corresponding aldehydes and ketones proceeds by simple treatment with PhI(OAc)2 and a catalytic amount of bromide ions, Bu4NBr or KBr.
ChemInform Abstract: Iron(III) Catalyzed Halo‐Functionalization of Alkynes.
Authors: Catano Bryant , Lee John , Kim Claudia , Farrell David , Petersen Jeffrey L. , Xing Yalan
Published: September 2015

The FeCl3‐catalyzed reaction of alkynes with NBS or NIS in methanol provides α,α‐dihalodimethyl ketals in excellent yields.
ChemInform Abstract: A General Pd‐Catalyzed α‐ and γ‐Benzylation of Aldehydes for the Formation of Quaternary Centers.
Authors: Franzoni Ivan , Guenee Laure , Mazet Clement
Published: September 2015

Using benzyl methyl carbonates as substrate, a series of α‐branched aldehydes is benzylated.
ChemInform Abstract: Difunctionalization of Alkenes via the Visible‐Light‐Induced Trifluoromethylarylation/1,4‐Aryl Shift/Desulfonylation Cascade Reactions.
Authors: Zheng Lewei , Yang Chao , Xu ZhaoZhong , Gao Fei , Xia Wujiong
Published: September 2015

α,β‐Unsaturated imide alkenes are found to undergo a visible light induced trifluoromethylarylation/1,4‐aryl shift/desulfonylation cascade to yield oxindoles.
ChemInform Abstract: Direct Aerobic Carbonylation of C(sp2)—H and C(sp3)—H Bonds Through Ni/Cu Synergistic Catalysis with DMF as the Carbonyl Source.
Authors: Wu Xuesong , Zhao Yan , Ge Haibo
Published: September 2015

The direct carbonylation of C—H bonds of aromatic and aliphatic amides is achieved via nickel/copper synergistic catalysis under atmospheric oxygen with the assistance of a bidendate directing group.
ChemInform Abstract: Biocatalytic Asymmetric Synthesis of Optically Pure Aromatic Propargylic Amines Employing ω‐Transaminases.
Authors: Schmidt Nina G. , Simon Robert C. , Kroutil Wolfgang
Published: September 2015

Both products enantiomers are accessible using different ω‐transaminases.
ChemInform Abstract: Tandem Z‐Selective Cross‐Metathesis/Dihydroxylation: Synthesis of anti‐1,2‐Diols.
Authors: Dornan Peter K. , Wickens Zachary K. , Grubbs Robert H.
Published: September 2015

Ruthenium catalyzes both the metathesis reaction as well as the dihydroxylation reaction upon addition of NaIO4.
ChemInform Abstract: Metal‐Free, Regio‐ and Stereoselective Synthesis of Linear (E)‐Allylic Compounds Using C, N, O, and S Nucleophiles.
Authors: Huang Xiaojun , Fulton Brandon , White Kana , Bugarin Alejandro
Published: September 2015

Bromination of alkenes (I) give the corresponding dibromides which are further converted into linear (E)‐allylic compounds upon treatment with various nucleophiles.
ChemInform Abstract: Synthesis of Unsymmetric Tertiary Amines via Alcohol Amination.
Authors: Pang Shaofeng , Deng Youquan , Shi Feng
Published: September 2015

A novel selective one‐pot synthesis of unsymmetric tertiary amines catalyzed by a simple hydrothermally formed Cu/Al oxide catalyst is introduced.
ChemInform Abstract: Microwave Mediated Solvent Free Synthesis of Formazans Catalyzed by Simple Ionic Liquids Derived from Dialkylammonium Salts.
Authors: Das Pranab Jyoti , Begum Jesmin
Published: September 2015

Diethylammonium hydrogensulfate as an ionic liquid catalyst in the microwave‐assisted one‐pot three‐component reaction between arylamines (I), benzaldehydes (II) or (V) and phenylhydrazine (III) furnishes the formazans (IV) and (VI) in highs yield following a volatile‐organic‐compound‐ and solvent‐free green protocol.
ChemInform Abstract: Synthesis of N‐Substituted Aryl Amidines by Strong Base Activation of Amines.
Authors: Khalifa Muhammad M. , Bodner Micah J. , Berglund J. Andrew , Haley Michael M.
Published: September 2015

Primary amines react with nitriles in the presence of BuLi to give amidines.
ChemInform Abstract: Magnetic Nanoparticles Supported Oxime Palladacycle as a Highly Efficient and Separable Catalyst for Room Temperature Suzuki—Miyaura Coupling Reaction in Aqueous Media.
Authors: Gholinejad Mohammad , Razeghi Mehran , Najera Carmen
Published: September 2015

A novel magnetic nanoparticle‐supported oxime palladacycle catalyst is successfully prepared and characterized.
ChemInform Abstract: Copper(I)‐Catalyzed Coupling Reaction of Aryl Boronic Acids with N,O‐Acetals and N,N‐Aminals under Atmosphere Leading to α‐Aryl Glycine Derivatives and Diarylmethylamine Derivatives.
Authors: Sakai Norio , Hori Hiroaki , Yoshida Yoshihiro , Konakahara Takeo , Ogiwara Yohei
Published: September 2015

The reaction tolerates cyclic and acyclic N,O‐acetals endowed with a coordinating ester, a coordinating aryl group or no substituent as well as N,N‐aminals.
ChemInform Abstract: Access to Spirocyclized Oxindoles and Indolenines via Palladium‐Catalyzed Cascade Reactions of Propargyl Carbonates with 2‐Oxotryptamines and Tryptamines.
Authors: Nibbs Antoinette E. , Montgomery Thomas D. , Zhu Ye , Rawal Viresh H.
Published: September 2015

A variety of the desired N‐heterocyclic scaffolds, required for alkaloid preparation, is best available by reaction of the educts with propargyl carbonate (II).
ChemInform Abstract: Diversity‐Oriented Approach to Spirooxindoles: Application of a Green Reagent ′Rongalite′.
Authors: Kotha Sambasivarao , Ali Rashid
Published: September 2015

Various functionalized spirooxindole derivatives are synthesized under operationally simple reaction conditions without isolation of the intermediates during the synthetic sequence.
ChemInform Abstract: Four‐Component Reaction Between Naphthols, Substituted β‐Nitrostyrenes, Substituted Benzaldehydes and Ammonium Acetate in Water—PEG‐400: An Approach to Construct Polysubstituted Naphthofuranamines.
Authors: Zhang Jungui , Yao Juan , Liu Jiaming , Xue Shuwen , Li Yang , Wang Cunde
Published: September 2015

involving a sequence of Michael reaction, aza‐ene reaction, imine‐enamine/keto‐enol tautomerization, O‐cyclization and aromatization as key steps
ChemInform Abstract: Dienamine and Friedel—Crafts One‐Pot Synthesis, and Antitumor Evaluation of Diheteroarylalkanals.
Authors: Frias Maria , Padron Jose M. , Aleman Jose
Published: September 2015

A two‐step, one‐pot procedure is developed to cyclize dialdehydes of type (I) in the presence of diphenylsilyl prolinol and subsequent condensation with indoles to give enantioenriched 2,3′‐connected diheteroarylalkanals with good enantioselectivities.
ChemInform Abstract: Direct Aromatic C—H Trifluoromethylation via an Electron‐Donor—Acceptor Complex.
Authors: Cheng Yuanzheng , Yuan Xiangai , Ma Jing , Yu Shouyun
Published: September 2015

A simple method for the direct C—H trifluoromethylation of mainly indoles and pyrroles using Umomoto′s reagent under mild conditions is developed.
ChemInform Abstract: Organocatalytic Enantioselective Peroxidation of Ketimines Derived from Isatins.
Authors: Nakamura Shuichi , Takahashi Shun
Published: September 2015

Optimized reaction conditions allow the enantioselective addition of hydroperoxides to ketimines (I) to give α‐aminoperoxides.
ChemInform Abstract: Palladium‐Catalyzed C—H Ethoxycarbonyldifluoromethylation of Electron‐Rich Heteroarenes.
Authors: Shao Changdong , Shi Guangfa , Zhang Yanghui , Pan Shulei , Guan Xiaohong
Published: September 2015

A Pd‐catalyzed reaction of electron‐rich heteroarenes with ethyl bromodifluoroacetate is presented which allows the synthesis of a diverse range of ethoxycarbonyldifluoromethylated heteroarenes, generally in a highly regioselective manner.
ChemInform Abstract: Cobalt(II)/Silver Relay Catalytic Isocyanide Insertion/Cycloaddition Cascades: A New Access to Pyrrolo[2,3‐b]indoles.
Authors: Gao Qian , Zhou Peng , Liu Feng , Hao Wen‐Juan , Yao Changsheng , Jiang Bo , Tu Shu‐Jiang
Published: September 2015

A novel Co/Ag bimetallic catalyzed bicycloaddition of arylethynylanilines (I) and (IV) with isonitriles is presented.
ChemInform Abstract: C(sp3)—C(sp3) Bond Cleavage in the Palladium‐Catalyzed Aminohydroxylation of Allylic Hydrazones Using Atmospheric Oxygen as the Sole Oxidant
Authors: Chen Yu‐Chen , Zhu Ming‐Kui , Loh Teck‐Peng
Published: September 2015

affording various substituted 1H‐pyrazoles
ChemInform Abstract: One‐Pot Synthesis of 5‐Alkoxy‐4‐amino‐3‐halo‐2(5H)‐furanones Containing Benzimidazole Moiety in the Absence of Metal Catalyst
Authors: Peng Pai , Feng Min‐Hua , Shi Jie , Zheng Jia‐Li , Wu Yan‐Cheng , Wang Zhao‐Yang , Chen Ren‐Hong
Published: September 2015

21 examples
ChemInform Abstract: An Efficient and Confluent Approach for the Synthesis of Novel 3,4‐Dihydro‐2H‐naphtho[2,3‐e][1,3]oxazine‐5,10‐dione Derivatives by a Three Component Reaction in Ionic Liquid.
Authors: Khanna Garima , Aggarwal Komal , Khurana Jitender M.
Published: September 2015

A three component reaction of 2‐hydroxy‐1,4‐naphthoquinone, anilines, and formaldehyde is developed in [bmim]BF4 as catalytic solvent to give the title compounds (IV) in excellent yields.
ChemInform Abstract: Palladium‐Catalyzed Desulfurative Sonogashira Cross‐Coupling Reaction of 3‐Cyano Assisted Thioamide‐Type Quinolone Derivatives with Alkynes
Authors: Wu You , Xing Yongning , Wang Jie , Sun Qi , Kong Weiqi , Suzenet Franck
Published: September 2015

affording alkynylated quinoline derivatives
ChemInform Abstract: Novel Synthesis of Isoquinoline Derivatives Derived from (Z)‐4‐(1,3‐Diphenylpyrazol‐4‐yl)isochromene‐1,3‐dione.
Authors: Mahmoud Mahmoud R. , El‐Shahawi Manal M. , Abou‐Elmagd Wael S. I. , Hekal Mohamed H.
Published: September 2015

A series of novel isoquinoline derivatives are synthesized by reaction of the title isochromenedione (I) with hydrazides, amines, diamines, and 2‐aminothiophenol.
ChemInform Abstract: Stereoselective Synthesis of Chiral Polycyclic Indolic Architectures Through Pd0‐Catalyzed Tandem Deprotection/Cyclization of Tetrahydro‐β‐carbolines on Allenes.
Authors: Gobe Valerian , Guinchard Xavier
Published: September 2015

Enantioenriched indole substrates, prepared by Pictet—Spengler reaction, undergo deprotection/cyclization reactions.
ChemInform Abstract: Cu(I)‐Catalyzed Synthesis of N‐Tosyl‐4‐iminoquinolizines.
Authors: Chen Joanna L. , Namirembe Sheila , Lauchert Luke T. , Tsougranis Gregory H. , Isaacs Andre K.
Published: September 2015

Ketenimines generated in situ from 2‐pyridyl compounds and azide (II) undergo an intramolecular cyclization reaction to yield iminoquinolizines.
ChemInform Abstract: Direct Amination of Pyrimidin‐2‐yl Tosylates with Aqueous Ammonia under Metal‐Free and Mild Conditions.
Authors: Gong Hai‐Peng , Zhang Yue , Da Yu‐Xia , Zhang Zhang , Quan Zheng‐Jun , Wang Xi‐Cun
Published: September 2015

The reaction is not sensitive to steric or electronic effects of the substituents.
ChemInform Abstract: Formation of Carbocycles via a 1,4‐Rh Shift Triggered by a Rhodium‐Catalyzed Addition of Terminal Alkynes to 3,3‐Diarylcyclopropenes.
Authors: Sawano Takahiro , Hashizume Minoru , Nishimoto Shouta , Ou Keiyu , Nishimura Takahiro
Published: September 2015

The title reaction provides silylated tricyclic addition products which can be further converted into naphthalene derivatives as shown in case of product (IIIb).
ChemInform Abstract: Synthesis of Vinyl Trifluoromethyl Selenoethers.
Authors: Wu Chuyi , Huang Yangjie , Chen Zhirong , Weng Zhiqiang
Published: September 2015

The trifluoromethylselenolation of vinyl halides with copper reagent (II) proceeds under mild conditions and tolerates a variety of functional groups.
ChemInform Abstract: Antiinflammatory Sesquiterpenes from the Medicinal Herb Tanacetum sinaicum.
Authors: Hegazy Mohamed‐Elamir F. , Hamed Ahmed R. , Mohamed Tarik A. , Debbab Abdessamad , Nakamura Seikou , Matsuda Hisashi , Pare Paul W.
Published: September 2015

From newly isolated sesquiterpenes (I), (II), and (III) only (I) shows intermediate inhibition of NO production in a mouse peritoneal macrophage system (IC50: 15.7 μM).
ChemInform Abstract: Two New Triterpene Saponins from Acanthophyllum laxiusculum
Authors: Pertuit David , Baghery Lotfabad Tayebe , Mitaine‐Offer Anne‐Claire , Miyamoto Tomofumi , Tanaka Chiaki , Lacaille‐Dubois Marie‐Aleth
Published: September 2015

isolation and structure determination
ChemInform Abstract: Enantiomeric 3‐Arylcoumarins and 2‐Arylcoumarones from the Roots of Glycyrrhiza uralensis as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors.
Authors: Ji Shuai , Qiao Xue , Li Zi‐wei , Wang Yong‐rui , Yu Si‐wang , Liang Wen‐fei , Lin Xiong‐hao , Ye Min
Published: September 2015

All compounds show significant inhibitory activities against PTP1B.
ChemInform Abstract: Anisotropically Branched Metal Nanostructures
Authors: Ye Enyi , Regulacio Michelle D. , Zhang Shuang‐Yuan , Loh Xian Jun , Han Ming‐Yong
Published: September 2015

Review: syntheses, properties and applications; 50 refs.
ChemInform Abstract: Anion Binding with Urea and Thiourea Derivatives
Authors: Blazek Bregovic Vesna , Basaric Nikola , Mlinaric‐Majerski Kata
Published: September 2015

Review: 387 refs.
ChemInform Abstract: Toward the Synthesis of More Reactive S = 2 Non‐Heme Oxoiron(IV) Complexes
Authors: Puri Mayank , Que Lawrence Jr.
Published: September 2015

Review: 66 refs.
ChemInform Abstract: Ruthenium Metal Complexes and Their Biological Approach — A Short Review
Authors: Naik Kokkanur Hirya Naik Kumar , Bhimareddy Ashok , Naik Nagaraja
Published: September 2015

Review: 120 refs.
ChemInform Abstract: Advances and Challenges in Palladium‐Catalyzed Intermolecular Selective Allylic C—H Functionalization of Alkenes
Authors: Qi Xiaoxu , Chen Pinhong , Liu Guosheng
Published: September 2015

Review: 28 refs.
ChemInform Abstract: Understanding the Chemistry Behind the Antioxidant Activities of Butylated Hydroxytoluene (BHT): A Review
Authors: Yehye Wageeh A. , Rahman Noorsaadah Abdul , Ariffin Azhar , Abd Hamid Sharifah Bee , Alhadi Abeer A. , Kadir Farkaad A. , Yaeghoobi Marzieh
Published: September 2015

Review: 189 refs.
ChemInform Abstract: Coumarins as Anticancer Agents: A Review on Synthetic Strategies, Mechanism of Action and SAR Studies
Authors: Thakur Anuradha , Singla Ramit , Jaitak Vikas
Published: September 2015

Review: 104 refs.
ChemInform Abstract: A Brief Introduction to the Development of Biogenic Synthesis of Metal Nanoparticles
Authors: Mondal Samiran , Basu Saswati , Begum Naznin Ara , Mandal Debabrata
Published: September 2015

Review: 70 refs.
ChemInform Abstract: Hydrogen Deuterium Mass Spectrometry in Drug Discovery
Authors: Campobasso Nino , Huddler Donald
Published: September 2015

Review: 25 refs.
Selective early expression of the orphan nuclear receptor Nr4a2 identifies the claustrum homolog in the avian mesopallium: Impact on sauropsidian/mammalian pallium comparisons
Authors: Puelles L. , Ayad A. , Alonso A. , Sandoval J.E. , MartÍnez‐de‐la‐Torre M. , Medina L. , Ferran J.L.
Published: September 2015

The transcription factor Nr4a2 was recently revealed as a very early developmental marker of the claustrum (CL) proper in the mouse. The earliest claustral primordium was identified superficially, dorsal to the olfactory cortex, and was subsequently covered by the Nr4a2‐negative cells of the insular cortex. Some tangentially migrating claustral derivatives (subplate cells and some endopiriform elements) also expressed this marker. The present study employs the same genetic marker to explore the presence of a comparable pallial division in chicken in which, in principle, the same pallial sectors exist as in mammals. We were indeed able to delineate an early‐developing Nr4a2‐positive mantle domain at the expected topologic position within the developing chicken lateral pallium. In the chicken as well as in the turtle (from data in the literature), the earliest postmitotic lateropallial cells likewise express Nr4a2 and occupy a corticoid superficial stratum of the mesopallium, which is clearly comparable in spatial and chronological profile to the mouse CL. Other cells produced in this pallial sector include various tangentially migrating Nr4a2‐labeled derivatives as well as Nr4a2‐negative and Nr4a2‐positive local deeper subpopulations that partially interdigitate, forming mesopallial core and shell populations. We hold that the deep avian and reptilian mesopallial formation developing under the superficial corticoid CL homolog represents a field homolog of the insula, although additional studies are required to underpin this hypothesis. J. Comp. Neurol. 524:665–703, 2016. © 2015 Wiley Periodicals, Inc.
Ultrastructure of geniculocortical synaptic connections in the tree shrew striate cortex
Authors: Familtsev Dmitry , Quiggins Ranida , P. Masterson Sean , Dang Wenhao , Slusarczyk Arkadiusz S. , Petry Heywood M. , Bickford Martha E.
Published: September 2015

To determine whether thalamocortical synaptic circuits differ across cortical areas, we examined the ultrastructure of geniculocortical terminals in the tree shrew striate cortex to compare directly the characteristics of these terminals with those of pulvinocortical terminals (examined previously in the temporal cortex of the same species; Chomsung et al. [] Cereb Cortex 20:997–1011). Tree shrews are considered to represent a prototype of early prosimian primates but are unique in that sublaminae of striate cortex layer IV respond preferentially to light onset (IVa) or offset (IVb). We examined geniculocortical inputs to these two sublayers labeled by tracer or virus injections or an antibody against the type 2 vesicular glutamate antibody (vGLUT2). We found that layer IV geniculocortical terminals, as well as their postsynaptic targets, were significantly larger than pulvinocortical terminals and their postsynaptic targets. In addition, we found that 9–10% of geniculocortical terminals in each sublamina contacted GABAergic interneurons, whereas pulvinocortical terminals were not found to contact any interneurons. Moreover, we found that the majority of geniculocortical terminals in both IVa and IVb contained dendritic protrusions, whereas pulvinocortical terminals do not contain these structures. Finally, we found that synaptopodin, a protein uniquely associated with the spine apparatus, and telencephalin (TLCN, or intercellular adhesion molecule type 5), a protein associated with maturation of dendritic spines, are largely excluded from geniculocortical recipient layers of the striate cortex. Together our results suggest major differences in the synaptic organization of thalamocortical pathways in striate and extrastriate areas. J. Comp. Neurol. 524:1292–1306, 2016. © 2015 Wiley Periodicals, Inc.
Treating youth in pain: Comparing tailored behavioural medicine treatment provided by physical therapists in primary care with physical exercises
Authors: Holm S. , Ljungman G. , Åsenlöf P. , Linton S.J. , Söderlund A.
Published: September 2015

Objectives

To study the efficacy of tailored behavioural medicine treatment within a physical therapy framework.

Methods

The study was a randomized controlled study (RCT): tailored behavioural medicine treatment (EXT) delivered by physical therapists (PTs) was compared with exercise‐based treatment (CT). Thirty‐two adolescents (mean age 14.3 years) with persistent pain participated. Data on pain‐related disability and school attendance (primary outcomes), pain intensity, catastrophizing, fear of movement and self‐efficacy were collected.

Results

The pain‐related disability measured by the Functional Disability Inventory (FDI) resulted in mean score change of EXT = −18 and CT = −11, respectively. A significant change within both groups was found (EXT p = 0.003, CT p = 0.001), and a large effect size for FDI between the conditions was demonstrated (AUC of 0.77). For school attendance post‐treatment, no difference was found between conditions. For secondary outcomes, a significant improvement in pain intensity and pain catastrophizing was found for the EXT and self‐efficacy for the CT groups but no statistically significant difference between the two conditions was detected. Caution should be given to the small sample size, as it may affect the interpretation and generalizability of the results.

Conclusion

In this study, differences between tailored behavioural medicine treatment delivered by PTs and exercise‐based treatment could not be demonstrated, although the effect size was large. Patients who received either treatment demonstrated significant changes over time in pain‐related disability. The low number of participants and suboptimal tailoring of the psychological components may partly explain the failure to demonstrate differences between groups, and future studies are warranted.
Estimation of the silica solubility in the superheated steam using LSSVM modeling approach
Authors: Ahmadi Mohammad Ali , Rozyn Jake , Lee Moonyong , Bahadori Alireza
Published: September 2015

The presence of silica (SiO2) in boiler water causes precipitation and creates hard silicate scale on steam turbine blades. This study assessed the ability of least squares support vector machines (LSSVM) modeling approaches to estimate the solubility of SiO2 in the steam of boilers. A genetic algorithm (GA) and population‐based stochastic search algorithms were employed to identify the optimal LSSVM method variables. Results indicate that the GA‐LSSVM can be used to model the complicated nonlinear relationship between the input and output variables. To predict the solubility of SiO2 in the steam of boilers, the GA‐LSSVM model generated the mean absolute error (MAE) and the coefficient of determination (R2) values of 1.8831 and 0.9997, respectively, for the entire data set. The proposed model provides a distinctly promising approach to estimating the solubility of SiO2 in the steam of boilers. © 2015 American Institute of Chemical Engineers Environ Prog, 35: 596–602, 2016
Energy efficient relay networks with wireless power transfer from a multi‐antenna base station
Authors: Wang Xinhua , Liu Ju , Zhai Chao , Ma Shuang , Wang Qing
Published: September 2015

In this paper, we investigate the energy efficiency (EE) of a decode‐and‐forward relay network with wireless energy harvesting. The data transmission between a multi‐antenna base station (BS) and its user equipment is assisted by an intermediate relay node, which operates with the wireless energy harvesting. The BS firstly transmits energy and information to the relay node, which can harvest the energy and retract the information simultaneously using the power‐splitting or time‐switching method. Then, the relay node forwards its decoded information to the user equipment using all the harvested energy. Through maximising the instantaneous EE for the power‐splitting‐based system, the optimal power‐splitting ratio and the optimal transmit power of the BS are derived in closed form for each time block. To maximise the instantaneous EE for the time‐switching‐based system, an optimisation algorithm is proposed to judiciously determine the harvesting time and the transmit power of the BS for each time block. Furthermore, we optimise the number of antennas N of the BS by taking into account the circuit power consumption, as it cannot be ignored when N is large. Finally, simulation results are presented to validate our derived closed‐form solutions and verify the efficiency of our proposed algorithm. Copyright © 2015 John Wiley & Sons, Ltd.
The intersection marker method for 3D interface tracking of deformable surfaces in finite volumes
Authors: Ho Mark , Yeoh Guan , Reizes John , Timchenko Victoria
Published: September 2015

Currently, the majority of computational fluid dynamics (CFD) codes use the finite volume method to spatially discretise the computational domain, sometimes as an array of cubic control volumes. The Finite volume method works well with single‐phase flow simulations, but two‐phase flow simulations are more challenging because of the need to track the surface interface traversing and deforming within the 3D grid. Surface area and volume fraction details of each interface cell must be accurately accounted for, in order to calculate for the momentum exchange and rates of heat and mass transfer across the interface. To attain a higher accuracy in two‐phase flow CFD calculations, the intersection marker (ISM) method is developed. The ISM method is a hybrid Lagrangian–Eulerian front‐tracking algorithm that can model an arbitrary 3D surface within an array of cubic control volumes. The ISM method has a cell‐by‐cell remeshing capability that is volume conservative and is suitable for the tracking of complex interface deformation in transient two‐phase CFD simulations. Copyright © 2015 John Wiley & Sons, Ltd.
MiR‐199a/b‐3p suppresses migration and invasion of breast cancer cells by downregulating PAK4/MEK/ERK signaling pathway
Authors: Li Shou‐Qing , Wang Zi‐Hang , Mi Xu‐Guang , Liu Lei , Tan Yan
Published: September 2015

MicroRNA‐199a/b‐3p is downregulated in several types of aggressive cancer, and its decrement significantly correlates with poor survival. Here, we aim to investigate the biological function of miR‐199a/b‐3p and its regulation of target genes in breast cancer cells with highly metastatic potential. In addition, we found that miR‐199a/b‐3p expression was much lower in MDA‐MB‐231, CAL120, and HCC1395 breast cancer cells with highly metastatic potential. Functional assays showed that restored miR‐199a/b‐3p expression inhibited MDA‐MB‐231 cell growth, cell‐cycle progression, migration, and invasion. In addition, we experimentally demonstrated that PAK4 was the direct target of miR‐199a/b‐3p, hypo‐expression of PAK4 suppressed proliferation, migration and invasion of MDA‐MB‐231 cells, and overexpression of PAK4 significantly rescued the inhibitory effect of miR‐199a/b‐3p on MDA‐MB‐231 cell growth, migration, and invasion. Further, we also observed that miR‐199a/b‐3p could inactivate the PAK4/MEK/ERK signaling pathway. Thus, miR‐199a/b‐3p functions as a tumor suppressor and has an important role in breast cancer metastasis through PAK4/MEK/ERK signaling pathway. © 2015 IUBMB Life, 67(10):768–777, 2015
Enterovirus 71 infection caused neuronal cell death and cytokine expression in cultured rat neural cells
Authors: Chang Cheng‐Yi , Li Jian‐Ri , Ou Yen‐Chuan , Chen Wen‐Ying , Liao Su‐Lan , Raung Shue‐Ling , Hsiao An‐Lu , Chen Chun‐Jung
Published: September 2015

Fatal enterovirus type‐71 (EV71) cases are associated with central nervous system infection characterized by inflammatory cell infiltration and activation, cytokine overproduction, and neuronal cell death. Although EV71 antigen has been detected in neurons and glia, the molecular mechanisms underlying EV71‐associated neuroinflammation and neuronal cell death are not fully understood. Using cultured rodent neural cell models, we found that EV71 infection preferentially caused cell death in neurons but not brain‐resident immune cells astrocytes and microglia. Neurons, astrocytes, and microglia responded to EV71 infection by releasing distinct profiles of cytokines, including nitric oxide (NO), tumor necrosis factor‐α (TNF‐α), interleukin (IL)−1β, regulated on activation normal T cell expressed and secreted (RANTES), and glutamate. EV71 infection‐induced neuronal cell death correlated well with the elevated production of NO, TNF‐α, IL‐1β, and glutamate as well as activation of microglia. Exogenous addition studies further demonstrated the neurotoxic potential of NO, TNF‐α, IL‐1β, and glutamate. EV71 infection‐induced cytokine expression was accompanied by activation of protein tyrosine phosphorylation, mitogen‐activated protein kinases (MAPKs), and NF‐κB. Intriguingly, EV71 susceptibility was accompanied by infection‐elevated neuronal human scavenger receptor class B member 2 expression in cultured neural cells with age‐dependent manner. Biochemical and pharmacological studies revealed that after EV71 infection, microglia and accompanied cytokines play an active role in triggering bystander damage to neurons involving the tyrosine kinase/MAPKs/NF‐κB signaling cascade. These data suggest that bystander damage caused by activated glia particularly the microglia could be an alternative mechanism of EV71‐associated neuronal cell death. However, its clinical importance and implication require further investigation. © 2015 IUBMB Life, 67(10):789–800, 2015
Biomedical applications of soy protein: A brief overview
Authors: Tansaz Samira , Boccaccini Aldo R.
Published: September 2015

Soy protein (SP) based materials are gaining increasing interest for biomedical applications because of their tailorable biodegradability, abundance, being relatively inexpensive, exhibiting low immunogenicity, and for being structurally similar to components of the extracellular matrix (ECM) of tissues. Analysis of the available literature indicates that soy protein can be fabricated into different shapes, being relatively easy to be processed by solvent or melt based techniques. Furthermore soy protein can be blended with other synthetic and natural polymers and with inorganic materials to improve the mechanical properties and the bioactive behavior for several demands. This review discusses succinctly the biomedical applications of SP based materials focusing on processing methods, properties and applications highlighting future avenues for research. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 553–569, 2016.
Anti‐Inflammatory Effect of Ascochlorin in LPS‐Stimulated RAW 264.7 Macrophage Cells Is Accompanied With the Down‐Regulation of iNOS, COX‐2 and Proinflammatory Cytokines Through NF‐κB, ERK1/2, and p38 Signaling Pathway
Authors: Lee Sook‐Hyun , Kwak Choong‐Hwan , Lee Sung‐Kyun , Ha Sun‐Hyung , Park Junyoung , Chung Tae‐Wook , Ha Ki‐Tae , Suh Suk‐Jong , Chang Young‐Chae , Chang Hyeun Wook , Lee Young‐Choon , Kang Bong‐Seok , Magae Junji , Kim Cheorl‐Ho
Published: September 2015

A natural compound C23H32O4Cl, ascochlorin (ASC) isolated from an incomplete fungus, Ascochyta viciae has been known to have several biological activities as an antibiotic, antifungal, anti‐cancer, anti‐hypolipidemic, and anti‐hypertension agent. In this study, anti‐inflammatory activity has been investigated in lipopolysaccharide (LPS)‐induced murine macrophage RAW 264.7 cells, since ASC has not been observed on the inflammatory events. The present study has clearly shown that ASC (1–50 μM) significantly suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and decreased the gene expression of inducible NO synthase (iNOS) and cyclooxygenase‐2 (COX‐2) in a dose‐dependent manner. Moreover, ASC inhibited the mRNA expression and the protein secretion of interleukin (IL)‐1β and IL‐6 but not tumor necrosis factor (TNF)‐α in LPS‐stimulated RAW 264.7 macrophage cells. In addition, ASC suppressed nuclear translocation and DNA binding affinity of nuclear factor‐κB (NF‐κB). Furthermore, ASC down‐regulated phospho‐extracellular signal‐regulated kinase 1/2 (p‐ERK1/2) and p‐p38. These results demonstrate that ASC exhibits anti‐inflammatory effects in RAW 264.7 macrophage cells. J. Cell. Biochem. 117: 978–987, 2016. © 2015 Wiley Periodicals, Inc.
Ultrasound‐based clinical prediction rule model for detecting papillary thyroid cancer in cervical lymph nodes: A pilot study
Authors: Patel Nayana U. , McKinney Kristin , Kreidler Sarah M. , Bieker Teresa M. , Russ Paul , Roberts Katherine , Glueck Deborah H. , Albuja‐Cruz Maria , Klopper Joshua , Haugen Bryan R.
Published: September 2015

Purpose

To identify sonographic features of cervical lymph nodes (LNs) that are associated with papillary thyroid cancer (PTC) and to develop a prediction model for classifying nodes as metastatic or benign.

Methods

This retrospective study included the records of postthyroidectomy patients with PTC who had undergone cervical ultrasound and LN biopsy. LN location, size, shape, hilum, echopattern, Doppler flow, and microcalcifications were assessed. Model selection was used to identify features associated with malignant LNs and to build a predictive, binary‐outcome, generalized linear mixed model. A cross‐validated receiver operating characteristic analysis was conducted to assess the accuracy of the model for classifying metastatic nodes.

Results

We analyzed records from 71 LNs (23 metastatic) in 44 patients (16 with PTC). The predictive model included a nonhomogeneous echopattern (odds ratio [OR], 5.73; 95% confidence interval [CI], 1.07–30.74; p = 0.04), microcalcifications (OR, 4.91; 95% CI, 0.91–26.54; p = 0.06), and volume (OR, 2.57; 95% CI, 0.66–9.99; p = 0.16) as predictors. The model had an area under the curve of 0.74 (95% CI, 0.60–0.85), sensitivity of 65% (95% CI, 50% to 78%), and specificity of 85% (95% CI, 73% to 94%) at the Youden optimal cut point of 0.38.

Conclusions

Nonhomogeneous echopattern, microcalcifications, and node volume were predictive of malignant LNs in patients with PTC. A larger sample is needed to validate this model. © 2015 Wiley Periodicals, Inc. J Clin Ultrasound 44:143–151, 2016
Understanding and Engaging with Development through International Volunteering
Authors: Brown Eleanor Joanne
Published: September 2015

Understanding development issues and finding a space to interpret and debate our roles as citizens, consumers and individuals towards greater global justice are complex and contested. In this paper, I consider engagement in development through education‐based international volunteering and report on a case study of a 9‐month course designed to provide development education in preparation for a 2‐month period of international volunteering. I argue that through opening spaces for dialogue and experiential learning, international volunteering, accompanied by critical development education, has the potential to address questions about what responsible development might mean, and how we can actively contribute to it. Copyright © 2015 John Wiley & Sons, Ltd.
Rescuing Girls, Investing in Girls: A Critique of Development Fantasies
Authors: Caron Cynthia M. , Margolin Shelby A.
Published: September 2015

The girl child increasingly is at the centre of development programming. We draw on Slavoj Žižek's notion of fantasy to show how and, more importantly, why girl‐centred initiatives reproduce the shortcomings of women and gender‐focused programmes before them. Through an analysis of three girl‐centred campaigns, we illustrate how experts identify and diagnose girls' problems and prescribe solutions that not only circumscribe girls' futures, but are also counterproductive. We argue that even as campaigns try to integrate lessons learned from earlier gender and development initiatives, the critical reflection that a Žižekian approach promotes would better enable development actors to reformulate campaigns and fundamental campaign assumptions. Copyright © 2015 John Wiley & Sons, Ltd.
Measles surveillance in Taiwan, 2012–2014: Changing epidemiology, immune response, and circulating genotypes
Authors: Cheng Wen‐Yueh , Wang Hsiao‐Chi , Wu Ho‐Sheng , Liu Ming‐Tsan
Published: September 2015

In Taiwan, although the coverage rate of two doses of measles‐containing vaccine has been maintained at over 95% since 2001, measles outbreaks occurred in 2002, 2009, and 2011. The present study reports that 43 cases were confirmed by laboratory testing in Taiwan in 2012–2014 and that adults have emerged as one of groups susceptible to measles virus (MV) infection, who may have discrepant humoral immune reactions—indicated by the level of IgM and IgG antibodies compared to a naïve, susceptible measles case. Thirty‐seven of 43 cases confirmed by RT‐PCR were further characterized by genotyping. In Taiwan, genotype H1 was the major strain in circulation prior to 2010, while D9 was the most frequently detected MV genotype between 2010 and 2011. The genotyping data collected between 2012 and 2014 revealed that H1 rebounded in 2012 after an absence in 2011 and was imported from China and Vietnam. In 2014, genotype B3 first appeared in Taiwan following import from the Philippines and became the most frequently detected strain. Genotype D8, linked to importation from various countries, including India, Indonesia, Thailand, and Vietnam, showed sequence divergence. D9 was imported from Malaysia in 2014. The MV genotypes detected in Taiwan reflected the genotypes of circulating endemic measles strains in neighboring countries. A significant rise in the number of measles cases and in measles with genotypes imported from surrounding countries indicated that measles resurged in Asia in 2014. J. Med. Virol. 88:746–753, 2016. © 2015 Wiley Periodicals, Inc.
Computerized 3D morphological analysis of glenoid orientation
Authors: Ghafurian Soheil , Galdi Balazs , Bastian Sevag , Tan Virak , Li Kang
Published: September 2015

An accurate preoperative measurement of glenoid orientation is crucial for evaluating pathologies and successful total shoulder arthroplasty. Existing methods may be labor‐intensive, observer‐dependent, and sensitive to the misalignment between the scapula plane and CT scanning direction. In this study, we proposed a computation framework and performed an automated analysis of the glenoid orientation based on 3D surface data. Three‐dimensional models of 12 scapulae were analyzed. The glenoid cavity and external anatomical features were automatically extracted from these 3D models. Glenoid version was calculated using the scapula plane and the fulcrum axis alternatively. Glenoid inclination was measured both relative to transverse axis of the scapula and the medial pole‐inferior tip axis. The mean (±SD) of the fulcrum‐based glenoid version was −0.55° (±4.17°), while the scapular‐plane‐based glenoid version was −5.05° (±3.50°). The mean (±SD) of glenoid inclinations based on the medial pole and inferior tip was 12.75° (±5.03°) while the mean (±SD) of the glenoid inclination based on the medial pole and glenoid center was 4.63° (±4.86°). Our computational framework was able to extract the reproducible morphological measures free of inter‐ and intra‐ observer variability. For the first time in 3D, we showed that the fulcrum axis was practically perpendicular to the glenoid plane normal (radial line), and thus extended the fulcrum‐based glenoid version for quantifying 3D glenoid orientation. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:692–698, 2016.