bluuebunny/crossref_metadata_2025 huggingface dataset:
A Systematic Review of Hepatitis E Virus Detection in Camels
Authors: Santos-Silva Sérgio , Hemnani Mahima , Lopez-Lopez Pedro , Gonçalves Helena M. R. , Rivero-Juarez António , Van der Poel Wim H. M. , Nascimento Maria São José , Mesquita João R.
Published: May 2023

Hepatitis E virus (HEV) represents a major cause of acute hepatitis and is considered an emerging public health problem around the world. In the Middle East’s and Africa’s arid regions, where camels frequently interact with human populations and camel-derived food products are a component of the food chain, camel-borne zoonotic HEV infection is a potential threat. To date, no review paper has been published on HEV in camels. As such, the purpose of the current work is to provide a scientific review of the identification of HEV genotypes seven and eight in camels worldwide to have a better understanding of the current status of this topic and to identify gaps in the current knowledge. Searches were carried out in the electronic databases PubMed, Mendeley, Web of Science, and Scopus, including studies published until 31 December 2022 (n = 435). Once the databases were checked for duplicate papers (n = 307), the exclusion criteria were applied to remove any research that was not relevant (n = 118). As a result, only 10 papers were found to be eligible for the study. Additionally, in eight of the ten studies, the rates of HEV infection were found to be between 0.6% and 2.2% in both stool and serum samples. Furthermore, four studies detected HEV genotype seven in dromedary camels, and two studies have shown HEV genotype eight in Bactrian camels. Interestingly, these genotypes were recently reported in camels from the Middle East and China, where one human infection with HEV genotype seven has been associated with the consumption of contaminated camel meat and milk. In conclusion, more research will be needed to determine the prevalence of HEV infection in camels around the world as well as the risk of foodborne transmission of contaminated camel products. As camels are utility animals in several countries, HEV in these animals may pose a potential risk to public health.
Genetic Variability and Recombination of the NSP2 Gene of PRRSV-2 Strains in China from 1996 to 2021
Authors: Zhang Hang , Luo Qin , Zheng Yajie , Sha Huiyang , Li Gan , Kong Weili , Huang Liangzong , Zhao Mengmeng
Published: May 2023

Porcine reproductive and respiratory syndrome (PRRS) is one of the most serious infectious diseases that detrimentally affects the pig industry worldwide. The disease, which is typically difficult to control, is an immunosuppressive disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV), the genome of which (notably the NSP2 gene) undergoes rapid mutation. In this study, we sought to determine the genetic variation in the PRRSV-2 NSP2 gene in China from 1996 to 2021. Strain information was obtained from the GenBank database and analyzed from a molecular epidemiological perspective. We compared the nucleotide and amino acid homologies of the NSP2 sequences of different PRRSV-2 lineages, and examined phylogenetic relationships based on an analysis of the NSP2 sequences of 122 strains. The results revealed that NADC-30-like strains, which are represented by lineage 1, and HP-PRRSV strains, which are represented by lineage 8, were the most prevalent in China from 1996 to 2021. Close similarities were detected in the genetic evolution of lineages 3, 5, and 8. For nucleotide and amino acid sequence comparisons, we selected representative strains from each lineage, and for the NSP2 among different PRRSV-2 strains, we accordingly detected homologies of 72.5–99.8% and 63.9–99.4% at the nucleotide and amino acid levels, respectively, thereby indicating certain differences in the degrees of NSP2 amino acid and nucleotide variation. Based on amino acid sequence comparisons, we identified deletions, insertions, and substitutions at multiple sites among the NSP2 sequences of PRRSV-2 strains. Recombination analysis revealed the occurrence of five recombinant events among the 135 selected PRRSV-2 strains, and that there is a high probability of recombination of lineage 1 strains. The findings of this study enabled us to gain an in-depth understanding of the prevalence of PRRSV in China over the past 25 years and will contribute to providing a theoretical basis for evolution and epidemiology of the spread of PRRSV.
Spinning Submerged Filter Adsorber versus Packed Bed Adsorber for the Continuous Removal of Antibiotics from Wastewater with Activated Carbon
Authors: Obón José M. , Fernández-López José A. , Alacid Mercedes , Angosto José M.
Published: May 2023

The removal of antibiotics from wastewater is receiving considerable attention to fulfill water quality parameters required for reuse. This study compares a spinning submerged filter adsorber with a fixed bed adsorber for continuous antibiotic removal. Adsorbers were evaluated with micro granular activated carbon (μGAC: 508 μm), coarse powder activated carbon (cPAC: 197 μm), powder activated carbon (PAC: 77 μm), and a domestic wastewater effluent spiked with a mixture of amoxicillin, sulfamethoxazole, and levofloxacin with concentrations ranging from 10 to 50 mg/L. The fixed bed adsorber packed with cPAC was the most efficient adsorber running with wastewater spiked with 50 mg/L of each antibiotic and an empty bed contact time (EBCT) of 4.5 min. The spinning submerged filter adsorber configuration also provided high removal effectiveness using a 15 g/L concentration of PAC but with a lower hydraulic retention time (HRT) of 40 min. This adsorption unit can be filled with small PAC particles, unlike packed beds, and PAC concentrations can be increased up to 150 g/L if necessary. It combines adsorption and filtration with a completely mixed mode of operation in which the PAC concentration can be adapted to effluent micropollutant concentrations, making it an interesting alternative for adsorption processes.
Review on Drip Irrigation: Impact on Crop Yield, Quality, and Water Productivity in China
Authors: Yang Pei , Wu Lifeng , Cheng Minghui , Fan Junliang , Li Sien , Wang Haidong , Qian Long
Published: May 2023

The scarcity of freshwater resources is a global concern that is exacerbated by an increasing global population and climate change induced by global warming. To address this issue, the largest water-consuming sector has taken a series of measures termed as drip irrigation schemes. The primary purposes of drip irrigation are to reduce water scarcity near the root zone, reduce evaporation, and decrease water use. The application scope of drip irrigation is getting wider and wider, with the number of papers related to drip irrigation increasing year by year from 1990 to 2022. This study reviews crops planted in China that had been irrigated by drip irrigation equipment. The effects of drip irrigation technology on crop growth, physiology, quality, yield, and water use efficiency are summarized. This paper also provides an overview of drip irrigation technology on crop root development and nitrogen uptake. Through a global meta-analysis, it is found that in the case of water shortage, drip irrigation can save water and ensure crop yield compared to flooding irrigation, border irrigation, furrow irrigation, sprinkler irrigation, and micro-sprinkler irrigation. When the drip irrigation amount is more (100–120%), drip irrigation significantly increases crop yields by 28.92%, 14.55%, 8.03%, 2.32%, and 5.17% relative to flooding irrigation, border irrigation, furrow irrigation, sprinkler irrigation, and micro-sprinkler irrigation, respectively. When water resources are sufficient, increasing the amount of drip irrigation also improves crop yield. Moreover, the researchers found that drip irrigation can reduce fertilizer leaching and soil salinity. However, more studies should be conducted in the future to enrich the research on drip irrigation. In conclusion, drip irrigation technology is effective in improving crop growth, water use efficiency, and reducing water scarcity while decreasing fertilizer leaching and soil salinity, making it an ideal solution to the issue of freshwater resource scarcity globally.
Evaluating Statistical Machine Learning Algorithms for Classifying Dominant Algae in Juam Lake and Tamjin Lake, Republic of Korea
Authors: Hwang Seong-Yun , Choi Byung-Woong , Park Jong-Hwan , Shin Dong-Seok , Chung Hyeon-Su , Son Mi-Sun , Lim Chae-Hong , Chae Hyeon-Mi , Ha Don-Woo , Jung Kang-Young
Published: May 2023

South Korea’s National Institute of Environmental Research (NIER) operates an algae alert system to monitor water quality at public water supply source sites. Accurate prediction of dominant harmful cyanobacterial genera, such as Aphanizomenon, Anabaena, Oscillatoria, and Microcystis, is crucial for managing water source contamination risks. This study utilized data collected between January 2017 and December 2022 from Juam Lake and Tamjin Lake, which are representative water supply source sites at the Yeongsan River and Seomjin River basins. We performed an exploratory data analysis on the monitored water quality parameters to understand overall fluctuations. Using data from 2017 to 2021 as training data and 2022 data as test data, we compared the dominant algal classification accuracy of 11 statistical machine learning algorithms. The results indicated that the optimal algorithm varied depending on the survey site and evaluation criteria, highlighting the unique environmental characteristics of each site. By predicting dominant algae in advance, stakeholders can better prepare for water source contamination accidents. Our findings demonstrate the applicability of machine learning algorithms as efficient tools for managing water quality in water supply source systems using monitoring data.
Experimental Study of Geysering in an Upstream Vertical Shaft
Authors: Allasia Daniel G. , Böck Liriane Élen , Vasconcelos Jose G. , Pinto Leandro C. , Tassi Rutineia , Minetto Bruna , Persch Cristiano G. , Pachaly Robson L.
Published: May 2023

Transient flows in stormwater systems can lead to damaging and dangerous operational conditions, as exemplified by geysering events created by the uncontrolled release of entrapped air pockets. Extreme rain and associated rapid inflows may result in air pocket entrapment, which causes significant changes in flow conditions and potentially geysering. Stormwater geysers have been studied in different experimental and numerical modeling studies, as well as from limited data gathered within real systems. However, there is still no complete understanding of geysering events, as stormwater system geometries vary considerably. Most past studies involved releasing air from an intermediate shaft, in which a significant fraction of the entrapped air may bypass the release. This work advances the understanding of geysering by considering uncontrolled air release through an upstream shaft or manhole. In such cases, the entire air pocket is released upon reaching the shaft, worsening the occurrence of geysering. Pressure and water level measurements were performed for various combinations of initial water pressure, trapped air pocket volume, and vertical shaft geometries, indicating the higher severity of these geysering events. The results obtained also corroborate previous studies in that the measured pressure heads were lower than the grade elevation. Future studies should include larger-scale testing and the representation of this geometry using CFD.
Identifying the Groundwater Sources of Huangtupo Landslide in the Three Gorges Reservoir Area of China
Authors: Cao Shen , Xiang Wei , Wang Jinge , Cui Deshan , Liu Qingbing
Published: May 2023

Groundwater plays a crucial role in triggering and reactivating deep-seated landslides. However, classical hydrogeological investigations have limitations in their applicability to deep-seated landslides due to anisotropic and heterogeneous media. The Huangtupo landslide in the Three Gorges Reservoir area has garnered significant attention due to its high hazard potential. Of particular interest is the NO.1 Riverside Sliding Mass (HTP-1), which has shown notable deformation and has become the primary focus of landslide research. The study aims to investigate the sources of water in the HTP-1 landslide through hydrochemical analysis. This was achieved by monitoring the major ion content in the groundwater within the landslide for one year. Furthermore, stable isotope investigations were conducted on the groundwater in and around the landslide area, and an analysis of the mineral composition of the landslide soil was also performed. The results indicate that the groundwater in the landslide area (LGW) is a mixture of karst groundwater (KGW) from the adjacent upslope and local precipitation (LP). The karst groundwater is a major contributor to the recharge of the landslide groundwater system, causing a high component of groundwater that can easily exceed the critical level that causes landside failure during heavy rainfall events. Furthermore, prior to the relocation of residents from the Huangtupo landslide, the landslide groundwater was also impacted by human sewage, which not only affected the chemical composition of groundwater, but also had potential implications for slope stability. These findings provide a more scientific basis for the design and implementation of interception and drainage measures for the Huangtupo landslide and other large-scale landslides with similar geological conditions in the Three Gorges Reservoir area.
Effects of Spontaneous Fluorescent Polystyrene on Nostocaceae and Daphnia Magna
Authors: Qiu Shaolin , Yuan Wenjiao , Qin Yujie , Feng Xin , Li Meitong , Xie Yuhong
Published: May 2023

Microplastic pollution is widespread around the world and inevitably comes into contact with organisms. With the accumulation of microplastics in the environment, the negative impact of microplastics on organisms has become the main focus in the field of microplastics. In this study, the different particle and concentration effects of fluorescent polystyrene microplastics (PS-MPs) on Nostocaceae and Daphnia Magna were researched. The results indicate that PS-MPs adhered to Nostocaceae through static electricity, which hindered the absorption of photons and CO2 by Nostocaceae, resulting in a decrease in chlorophyll, a low growth rate and high mortality for Nostocaceae. PS-MPs with very small particles may be integrated into the blood of Daphnia Magna, leading to an increasing trend of mortality and a decrease in spawning rate. The research provides basic data and a reference for the effect of PS-MPs on freshwater organisms and has implications for the further study of microplastics.
Numerical Analyses of Slope Stability Considering Grading and Seepage Prevention
Authors: Feng Yuting , Yan Fuyu , Wu Lianrong , Lu Guangyin , Liu Taoying
Published: May 2023

The normal operation of the Yulangpei tailings reservoir is affected by landslide stability. In this paper, taking the main and side slopes near the dam bank of the Yulangpei ditch as an example, the water–soil coupling theory is applied to comprehensively evaluate the reliability of the side slopes of the tailings reservoir. Grading and seepage prevention (GSP) measures and the suction of the substrate are considered, as well as the infiltration of different rainfall and reservoir water levels. We numerically simulate the typical three forms of side slopes under the coupling conditions and conduct a reliable and comprehensive evaluation of the tailings reservoir side slopes. This study shows that the analysis of condition 1 indicates that the factor of safety (FS) of the bank slope shows a lag effect and that GSP can improve the FS of the slope, but not significantly for the main slope. The analysis of condition 2 shows that the weakening effect increases with the intensity of rainfall during the rainfall process, while the FS rebounds when the rainfall stops. The initial stability of the bank slope under different conditions improves after the GSP measures, but the main slope is more sensitive to the changes in rainfall and water level. The analysis of condition 3 shows that the overall trend of FS and displacement of the main slope shows a small decrease followed by a sharp increase. The FS of the side slope is negatively correlated with the change in total displacement, with a general trend of a slight increase followed by a sharp increase. After GSP, the overall FS of the main slope increases by about 3% and the total displacement decreases by about 87%, and the overall FS of the side slope increases by about 41%, while the total displacement decreases by about 66%.
Riverbed Morphologies Induced by Local Scour Processes at Single Spur Dike and Spur Dikes in Cascade
Authors: Aung HtayHtay , Onorati Beniamino , Oliveto Giuseppe , Yu Guoliang
Published: May 2023

Spur dikes are elongated structures extending from banks into rivers that mitigate erosion by forcing the flow away from the bank. The research on grouped spur dikes is insufficient in comparison with those on isolated spur dikes. Most of the studies focus on the maximum scour depth, omitting the bed morphological changes induced by local scour processes. Moreover, as yet, there is no established procedure for predicting the scour depth around spur dikes. This study aims to provide insights into the temporal and spatial morphological patterns around a single spur dike and spur dikes in cascade (three, five, and seven, consecutively). Experiments (of up to 318 h) were performed on a rectangular straight channel with dimensions of 20 m (length) × 1.0 m (width) × 1.0 m (depth). Nearly uniform sand with median grain size of 1.7 mm and sediment gradation of 1.5 was used for the mobile bed. The spacing between the elements for the spur dikes in cascade was 3b, where b is the spur dike width. All runs were conducted under a clear-water regime and steady flow conditions. Some limitations of the formulas for the equilibrium scour depth at the first spur dike reported in the literature were emphasised, with underestimations up to 160% and overestimations up to 200% at the earlier scour stages. The temporal evolution of the scour depth at the first spur dike was satisfactorily predicted with a correlation coefficient of 0.91. The scour processes at the other spur dikes were delayed and started at a dimensionless time greater than approximately 103. However, the scour rates increased to a high degree, with the scour depths tending to match those at the first spur dike.
Utilizing Electricity-Producing Bacteria Flora to Mitigate Hydrogen Sulfide Generation in Sewers through an Electron-Pathway Enabled Conductive Concrete
Authors: Vo Huy Thanh , Imai Tsuyoshi , Fukushima Masato , Suzuki Tasuma , Sakuma Hiraku , Hitomi Takashi , Hung Yung-Tse
Published: May 2023

This study aims to demonstrate the effectiveness of using biological oxidation for hydrogen sulfide (H2S) control. A long-term experiment was conducted using a rod-shaped electrode made of highly conductive concrete, which provided an electron pathway for H2S mitigation. Bacterial flora analysis was conducted using PCR-DGGE and metagenomic analysis by next-generation sequencing to identify electricity-producing bacteria. Results showed that H2S was effectively mitigated, and electricity-producing bacteria, including Geobacter sp. and Pelobacter sp., were found around the inner surface of the anode. The study found that highly conductive concrete can create an electron pathway for biological oxidation of H2S. Oxygen from the air layer near the surface of the water can act as an electron acceptor, even under anaerobic conditions, enabling effective H2S control in sewer systems.
Subcapsular Hepatic Hematoma Post Endoscopic Retrograde Cholangiopancreatography (ERCP): a case report
Authors: Dos Santos Mateus Araújo , Dos Santos Filho Paulo Vicente , Menezes Victor Cury , Fornari Jennifer Camila de Souza , Morita Tiago Oliveira
Published: May 2023

Subcapsular hepatic hematoma is a rare complication found after the  ERCP, which can lead to abdominal pain, anemia, fever and hypotension. The  case of a 34-year-old patient who developed a subcapsular liver hematoma after  ERCP is presented in this paper. The patient had abdominal pain and anemia,  which did not improve with conservative treatment. Drainage therapy was  performed, leading to remission of the condition.
Perfil epidemiológico: leishmaniose tegumentar americana no município de Cacoal - Rondonia
Authors: Casagrande Angelica Eloisa , Santana Karina Aparecida , De Souza Rebecca Satlher Dickel , Cruz Jessica Reco
Published: May 2023

A leishmaniose é uma dermatozoonose de grande distribuição e ampla incidência no Brasil. É originada por diversos protozoários do gênero Leishmania e é também transmitida pela picada de flebotomíneos. Comumente compromete pessoas que trabalham em florestas, como geólogos, agricultores, mineiros e técnicos florestais. Assim, é caracterizada como uma enfermidade ocupacional, porém, nos últimos anos, a LTA vem passando por uma urbanização. O objetivo do trabalho foi apresentar o perfil epidemiológico dos casos notificados de Leishmaniose Tegumentar Americana (LTA) no município de Cacoal (RO), no período de 2018 a 2022. Trata-se de um estudo epidemiológico, documental, quantitativo, descritivo e retrospectivo. Os dados foram obtidos do DATASUS/e-SUS, segundo sexo, faixa etária, raça, escolaridade, zona de moradia, critério de confirmação e evolução. Os resultados foram expressos por análise estatística descritiva. Entre 2018 e 2022, foram notificados 224 casos de LTA entre indivíduos de 0 e 76 anos, sendo 23 mulheres e 173 homens, 93% dos casos confirmados utilizaram o critério laboratorial. Concluiu-se que as notificações foram em sua grande maioria em pacientes do sexo masculino, pardos e brancos, de 5º a 8º série incompleta foram os mais afetados. Os locais de infecção são todos da zona rural e o critério de confirmação foi quase que predominantemente laboratorial e a evolução dos casos em sua maioria foi de cura. A cura clínica ocorreu em 67% dos casos e os anos que tiveram mais notificações foram em 2018 e 2020.
Análise da distribuição de mamógrafos no estado do Piauí
Authors: Barros Janaina Rodrigues , Da Silva Filho Wilson Seraine
Published: May 2023

O presente trabalho objetivou descrever e analisar a distribuição dos mamógrafos disponíveis para o Sistema único de Saúde (SUS) no Estado do Piauí com ênfase nas cidades mais populosas, verificando se a distribuição obedece a Portaria GM/MS 1.631. Por meio do estudo descritivo, exploratório e bibliográfico apurou-se dados a partir do site da CNES, referente a distribuição dos equipamentos, seu uso . Com base nisso, observou-se a diferença da distribuição nos estados brasileiros, tal como no Piauí, a quantidade de equipamentos cadastrados pelo SUS e a média aritmética do uso desses aparelhos. Conclui-se que, mesmo com o baixo número de mamógrafos em uso ao comparar com a distribuição de outros estados, algumas cidades do Piauí não obedecem à Portaria GM/MS n° 1.631, sendo evidente a diferença na distribuição e a falta de equipamentos em cidades com grande população.
Depressão na terceira idade: fatores desencadeantes e formas de intervenção
Authors: Ferraz Nathália Rocha , Oliveira Larissa Alencar , De Souza Maria Clara Veloso Maurício , Santana Ellen Carvalho Araújo , Santos Caroline Almeida , Almeida Emilly Santos , Caldeira Ludmylla ketlley , Santos Karoline Santana , Gomes Kleber Alves
Published: May 2023

Objetivo: Analisar os fatores desencadeadores da depressão em pacientes idosos e formas de intervenção para a melhoria da qualidade de vida. Métodos: Revisão Integrativa da Literatura baseada na pergunta norteadora. A pesquisa se iniciou nas plataformas de dados eletrônicas LILACS, Scielo e Pubmed com o auxílio das palavras-chave “idoso”, “depressão”, “intervenção” e “qualidade de vida”. As palavras-chave foram combinadas e organizadas com a utilização do operador booleano AND. Resultados: Vinte e nove estudos foram considerados aptos a serem discutidos nesta revisão. Discussão: Fatores genéticos, sentimentos de frustração, luto, baixa libido estão associados com sintomatologias depressivas. Sexo feminino, baixas condições socioeconomicas também podem influenciar no surgimento da doença. A associação de fármacos, psicoterapia e apoio familiar pode promover a manutenção da saúde. Considerações finais: Indivíduos idoso tem uma maior probabilidade de desenvolver transtornos psíquicos, especialmente a depressão. O isolamento social, dificuldades financeiras, núcleos familiares desestabilizados, a dependência econômica do sexo feminino, a baixa renda e a baixa escolaridade são fatores que propiciam à depressão. Os autores sugerem que, a psicoterapia, a terapia medicamentosa, a prática de atividade física, a reinserção social e o apoio familiar podem ser utilizadas como estratégias integradas para a melhoria da qualidade de vida dos pacientes idosos.
Comunicação buco-sinusal como consequência do deslocamento da raiz do segundo molar superior: Relato de caso
Authors: Abolis Thiago Gomes , Araújo Rafael de Sousa , Gonçalves Victória Laís Ribeiro , Marinho Luide Michael Rodrigues França , Carvalho Roberta Furtado
Published: May 2023

Introdução: Acidentes comunicação buco-sinusal refere-se a comunicação de origem iatrogênica entre a cavidade bucal e o seio maxilar (espaço caracterizado como pneumático localizado bilateralmente no osso maxilar), estando essa comunicação associada a extrações de dentes posteriores superiores, podendo ainda ocorrer não somente a descontinuidade na linha radiográfica que limita o assoalho maxilar como também o deslocamento de raízes de dentes superiores causado pelo uso de técnicas inadequadas gerando dessa forma possíveis alterações de natureza inflamatória/infecciosa no paciente. Sua principal forma de tratamento é cirúrgica realizada por retalhos palatino, vestibulares ou rotações de retalho de corpo adiposo. Objetivo: O presente artigo tem por objetivo relatar um caso de deslocamento de raiz de segundo molar superior para o seio maxilar após tentativa de exodontia da unidade dental. Relato de Caso: A paciente P.S.A, do sexo feminino, 35 anos de idade, parda, sem histórico de doenças crônicas, compareceu ao consultório com encaminhamento para avaliação clínica e radiográfica de uma complicação pós-cirúrgica.Após avaliação radiográfica ediagnóstico de deslocamento da raiz para o seio maxilar, a paciente foi submetida a técnica de Caldwell-Luc para retirada da raiz, sutura e proservação. Conclusão: A escolha correta da técnica a ser utilizada associada a uma anamnese minuciosa e exames complementares é indispensável para impedir que iatrogenias possam causar comunicação buco-sinusal.
A utilização da terapia genética com Car T Cells no tratamento do HIV
Authors: Caires Laryssa Thompson Vieira , Da Silva Camilly Vitoria Bezerra , Valadares Denise Nunes Rodrigues , Pinto Gabriela Ferreira , E Lima Giovanna Alves de Melo , Massai Isabela Ghannage , Cansanção Joselita Camila Bianor Farias , Silva Júlia Eduarda Souza , Soares Lara Lira , Vilela Luana Marques , Lopes Maria Luiza
Published: May 2023

Até os dias atuais não existe uma cura para a infecção por HIV (Human Immunodeficiency Virus), devido à grande capacidade de replicação e variação genética do vírus, o que tende a tornar muito mais complexas as criações de estratégias terapêuticas. A variabilidade do vírus é consequência da rápida replicação viral que tem a capacidade de produzir uma grande quantidade de vibriões por dia e a facilidade de uma recombinação genética dentro do indivíduo infectado. Nos últimos anos vem sendo desenvolvidos grandes interesses em aproveitar as capacidades do sistema imunitário para erradicar cancros avançados, ou seja, trata-se de um contexto oncológico. Sendo assim iniciou-se diversas tentativas para manipular de forma genética os linfócitos T, com isto criou-se a terapira com células CAR-T. A partir de estudos realizados em grupos capazes de realizar o controle da replicação do HIV na ausência do tratamento, foi concluído que o vírus se replica por meio de mediação das respostas do linfócito T CD8+. Com avanços notados por parte da engenharia celular, incluíram domínios de sinalização coestimulatórios que tinham a capacidade de alterar as características das células T, estes domínios foram o CD28 e 4-1BB, sendo este último, de grande importância na regulação de resposta imune com a capacidade de ativar e potencializar os linfócitos TCs.
Assistência de enfermagem ao recém-nascido pré- termo em Unidades de Terapia Intensiva Neonatal: revisão integrativa da literatura
Authors: Silva Romário Borges , Junqueira Marina da Silva , Silva Polyanne Barbosa , Costa Ronan Pereira , De Aguiar Teresinha Carvalho , Honostorio Noelly Ferreira , Silva Priscilla Patrícia Batista de Abreu
Published: May 2023

Introdução: Prematuridade Neonatal é um termo utilizado pela ciência da saúde para o nascimento do indivíduo antes do tempo considerado dentro da normalidade, ou seja, antes da 37ª semana de gestação. São classificados como: prematuros extremos, intermediários e prematuros tardios. A prematuridade neonatal é considerada um problema de saúde pública no Brasil, onde cerca de 280 mil bebês nascem, anualmente, antes de completarem 37 semanas de gestação, podendo este fato ocorrer por complicações maternas (ruptura prematura das membranas amnióticas, doenças maternas, asma, entre outras) e por indicação médica (presença de condição materna ou fetal que ocasione risco de morte para a mãe e/ou feto), necessitando de uma intervenção imediata. Objetivo: Buscar na literatura estudos que destaquem a assistência de enfermagem ao recém-nascido pré-termo em Unidades de Terapia Intensiva Neonatal. Metodologia: Trata-se de um estudo do tipo revisão integrativa da literatura no qual teve início no segundo semestre de 2021 e término no primeiro trimestre de 2022. Foram as bases de dados LILACS, SCIELO e BDENF. Resultados e Discussões: Foram encontradas 122 (cento e vinte e duas) publicações durante o período de 2017 a 2021, e destas, foram selecionadas 10 (dez) para a discussão do presente estudo. Foram evidenciados alguns riscos, tais como: hipotermia, infecção, integridade da pele prejudicada, icterícia, desequilíbrio hidroeletrolítico, amamentação interrompida, instabilidade glicêmica. Conclusão: Os cuidados prestados pela equipe de enfermagem aos recém-nascidos prematuros são diversos. Cabe destacar que, assim como outras unidades especializadas, os profissionais que atuam no setor de neonatologia atendem o público com características muito específicas, que exigem habilidades e conhecimentos específicos.
Hyper Low-cost Ultimate Rice Mechanization System
Authors: Ito Nobutaka
Published: May 2023

About 480 million tons of rice (milled rice base) are produced annually in the world. It is one of the cereals with a low trade rate for its production. In Asia, more than 90% of the world's production is produced. The top 10 countries in rice production are all Asian countries. The main operation of rice cultivation consists of planting, management while rice growing (weed & pest control, water management), harvesting, and post-harvest processing. In addition to infrastructure development such as irrigation and drainage system through field reclamation, the development of chemical fertilizers, herbicides, and pesticides contributed to labor saving. However, the introduction of the combine harvester, which can significantly save labor and simplify the harvesting operation, is one of the required parts of the technological innovation.

In this paper, one direction is shown to realize hyper-low cost of rice cultivation system through these technological innovations, demand and consumption increase of rice, and open up new markets as a response to the future food crisis.
Redescripción y nuevos registros geográficos de Doina asperula Clarke, 1978 (Lepidoptera: Depressariidae)
Authors: Urra Francisco
Published: May 2023

Se redescribe la especie Doina asperula Clarke, 1978; se entregan fotografías de las estructuras genitales del macho y nuevos registros geográficos.
Spatial inequality in Bangladesh: A geospatial analysis
Authors: Reyad Abdullah Ar , Ullah Mohammad Sofi Ullah
Published: May 2023

Spatial inequality of development is an important issue in Bangladesh. In this study a set of sectors-education, infrastructure, health, and economy-and sectoral components/indicators were selected aiming at investigating the spatial inequality scenario of Bangladesh. All components/indicators of each sector were weighted overlaid using ArcGIS tool. Finally, the overall spatial inequality of development was generated overlaying all the sectoral inequality maps. The spatial inequalities were revealed categorically from the highest overlaid cell value as the most lagged area to the lowest value as the most advance area. A serious centralized character towards the capital Dhaka was identified almost in all the sectors in spatial inequality maps of Bangladesh. The overall spatial inequality map identified a total of 16 districts in the comparatively ‘lagged area’ category; and 44 districts in the category of the ‘moderate area’. Only one district (the capital Dhaka) was identified in the category of ‘most advance area’, while three districts (Chittagong, Gazipur, Narayanganj) found in the ‘advance area’ category. Most of the lagged districts were identified in the north-west and north-east parts of Bangladesh. Besides, the districts of Chittagong Hill Tracts (Bandarban, Khagrachari, Rangamati) were also found most lagged..
Computational molecular structure analysis, electronic properties of sudan dye doped thioureabarium chloride crystals for nlo Applications
Authors: Nithiyanantham Subramanian , Panimalar S , Kumaresan P , Sambath Kumar K
Published: May 2023

Pure thiourea barium chloride (TBC) crystals were grown by slow evaporation from aqueous solution and slow cooling (0.1oC/ day). The growth was carried out for 21 days by keeping the bath at a temperature of 39oC.   Optimal molecular structures are explored by DFT / B3LYP method with 6-31G (d, p) based synthesis. Hyper conjugative interactions, charge delocalization and intra molecular hydrogen bonding have been analyzed using natural bond orbital (NBO) analysis. Moreover lower in the HOMO and LUMO energy gap explains the eventual charge transfer interactions taking place within the molecule, which influences the biological activity of the compound and also energy serves as a measure of the excitability of a compound, the smaller the energy gap, the more easily the compound will be excited.  Electronic structures were discussed and the displacement of the electron density was determined. Second – order perturbation theory analysis of the intra molecular bonds of Methyl Orange doped TBC were derived.
Experimental study of a breastshot waterwheel with the degree of inclination of the nozzle spray against the tip speed ratio
Authors: Kurniawan Muhammad Helmi , Ayuningtiyas Khusnul Khotimah , Syahrial Ridho Dwi
Published: May 2023

The energy crisis is a severe problem facing the world, including Indonesia. Along with the times, innovation is needed to implement sustainable energy. Non-fossil energy sources have not been widely used, and efforts are still needed to utilize these energy sources. The waterwheel was the first device used in water production. One of the innovations for the sustainability of non-fossil energy is to make a waterwheel. There are still several waterwheels in Indonesia, but an investigation is needed to determine their condition. So in this study, investigating the breastshot water wheel uses a nozzle-based construction with variations in the degree of inclination of the spray against the TSR value. The results showed that the greater the inclination of the nozzle angle, the higher the velocity of the water flow when it enters the wheel. Adding water speed to this wheel will increase the momentum and tangential force. An increase in the tangential force will increase the wheel's torque so that the wheel strength will increase. This increase in power will, of course, result in greater efficiency, thereby increasing the tip speed ratio (TSR).
From Diagrams to Fictions: Populated Plans and Their Buildings
Authors:   University of Illinois at Chicago, Hicks Stewart
Published: May 2023

This essay builds on and reacts to concepts initiated by Dora Epstein Jones in her essay, “Populated Plans.” Published in Log 45, as well as presented at a previous ACSA conference, Jones’ essay identified the emergence of a ubiquitous (in schools of architecture at least) “new” form of drawing that looks like an architectural plan but isn’t due to the inclusion of human figures. This type of drawing is distinct from a traditional plan, according to Jones, because it isn’t strictly “architectural notation—data received from the object,” nor a universalized geometric abstraction best suited for describing a building’s organization. The introduction of busy little people disrupts the universal and particularizes it by depicting scenes of fictional activity, lending the drawing to narrativity and the projection of alternative worlds. This freshly observed and codified instrument is well-suited to representing stories, fiction, and narrative as motive forces in the design of buildings. What kind of architecture do populated plan drawings produce? How do the rules governing their construction and the viewpoint of their projection influence outcomes? The essay draws parallels between fiction architecture and diagram architecture in an unconventional analogy to arrive at a possible answer. Despite the apparent conflict between their foundational underpinnings, fiction and data, respectively, the more comprehensively theorized diagrammatic practice offers useful concepts and frameworks of understanding for the emerging practice. Most importantly, the idea that a building could be the equivalent of a constructed abstraction, as Toyo Ito argues in his “Diagram Buildings” essay, leads to the possibility of a “populated plan building.” Ito outlines the role between data and the material reality of the building in “Diagram Building,” so what is the equivalent relationship between fiction, populated plans, and the buildings they produce?
Droplet Pavilion
Authors:   Laurentian University, Beites Steven
Published: May 2023

The pavilion explores the development of a novel hybrid façade system combining the fluid and ornate qualities of Ultra High Performance Concrete (UHPC) with the ephemeral and performative qualities of an Aluminum Composite (ACM) rainscreen system. Situated in one of the city’s oldest ravine networks, the project seeks to develop a distinct narrative thread in celebration of the area’s local heritage, highlighting the important connections with this site’s history and its natural environment. Within this region, 4 large ravines converge as three tributaries merge into the main river resulting in a series of river streams and undulating topographic conditions. The resulting rivers and creeks had a significant impact on the area’s history, represent¬ing an important source of energy for early European settlers and shaping the physical and social fabrics of the region.
Sentimen Analisis Masyarakat Indonesia Terhadap Presiden Rusia Pada Komentar Media Berita Online
Authors: Hafid Ihud , Gata Windu , Hilyati Khairunisa , Hakim Valianda Farradillah , Rahayu Sri
Published: May 2023

Tindakan Invasi Rusia ke Ukraina dikecam oleh berbagai pihak termasuk dari Indonesia. Sikap yang ditunjukkan oleh pemerintah Indonesia ternyata tidak sama dengan respon masyarakat Indonesia berdasarkan berbagai macam komentar pada halaman media berita online. Komentar yang pembaca berita online digunakan sebagai penilaian terhadap tokoh Presiden Rusia yang terlibat dalam konflik antara Rusia dan Ukraina dalam bentuk analisis sentimen. Penelitian ini berhasil mendapatkan data sebanyak 352 komentar yang berasal dari salah satu media berita online, data tersebut sebelumnya telah melalui tahap cleansing untuk menghilangkan duplikasi. Untuk mendapatkan informasi dasar pada komentar, Text mining dan Pre-Processing Text menjadi bagian penting dalam prosesnya. Algoritma klasifikasi yang digunakan oleh peneliti yaitu Support Vector Machine (SVM) dan Naive Bayes (NB) yang dioptimalkan menggunakan Particle Swarm Optimization (PSO). Kedua algoritma itu diuji dan memberikan hasil bahwa SVM berbasis PSO mendapatkan hasil akurasi terbaik yaitu sebesar 79.90% dan AUC 0.901.
Sistem Kipas Angin Otomatis Dengan Sensor Suhu dan Sensor Ultrasonik Berbasis Arduino
Authors: Adiyoga Abyarake , Chandra Dian Widiyanto
Published: May 2023

Ada beberapa faktor yang mempengaruhi suhu ruangan menjadi panas antara lain cuaca dan jumlah orang yang melebihi kapasitas. Beraktifitas didalam ruangan yang panas dapat mengganggu konsentrasi. Untuk mengatasi hal tersebut maka dibutuhkan alat untuk mendinginkan suhu ruangan seperti kipas angin. Namun seringkali orang lupa untuk mematikan kipas angin sehingga menyebabkan komponen kipas angin cepat rusak. Berdasarkan hal tersebut, penelitian ini bertujuan untuk merancang sebuah sistem kipas angin secara otomatis. Dengan memanfaatkan sensor suhu DHT11 dan sensor ultrasonik HC-SR04 serta dikendalikan oleh Arduino Uno. Hasil pengujian yang didapatkan adalah kipas angin akan hidup dalam kondisi suhu mencapai 300c atau jumlah orang dalam ruangan mencapai 10 orang dan kipas angin akan mati apabila tidak memenuhi kondisi tersebut. Dengan sistem seperti ini maka akan memperpanjang umur kipas angin dan membuat praktis dalam menyalakan atau mematikan kipas angin.
Wakaf Ahli: Dinamika Kebijakan Negara dan Sistem Pelaksanaannya di Malaysia
Authors: Ayatina Haerini
Published: May 2023

Dzurri waqf is also called waqf expert which is intended for family members, is an asset or a benefit that is waqf and managed by certain groups, namely the family or close relatives of the waqif (waqif) with the aim of public interest and benefit. Waqf experts are connected with Islamic family law. Waqf experts are able to help the waqif hand over assets to his family and descendants. The existence of the implementation of waqf experts is practiced by friends, such as Umar bin Khattab's waqf for his descendants and Uthman bin Affan's waqf. This article discusses policies and regulations from a legal standpoint and the implementation of waqf experts in institutions and institutions in Malaysia. Although relatively small, waqf management experts in Malaysia face difficulties in terms of rules and regulations. This study used a qualitative literature review method, then the data were analyzed systematically. The results show that the Majlis Religion of Islam and Malay Customs implemented waqf experts in Malaysia State of Kelantan in 1921. The specialty when implementing dzurri waqf is to guarantee the continuity of the benefits felt by family members as beneficiaries. The good thing about this is that the benefits produced grow and develop well for the good of mauquf alaih and the good of society. In addition, expert waqf management experts need to improve it in order to encourage its implementation in the future.
Evaluasi Kurikulum di MI Riyadul Falah Aikperapa Aikmel Lombok Timur Nusa Tenggara Barat
Authors: Wardi Muhammad Musfiatul , Aqodiah Aqodiah , Ali Mustopa
Published: May 2023

This study aims to determine the evaluation of the implementation of the 2013 curriculum at MI Riyadul Palah Aikperapa Aikmel East Lombok and to find out the obstacles to evaluating the implementation of the curriculum at MI Riyadul Falah Aikperapa. The school has been using the 2013 curriculum for a long time. The curriculum is a very important tool in realizing and achieving school education goals. On this basis, this study intends to find evaluations and obstacles to the implementation of the 2013 curriculum at MI Riyadul Palah Aikperapa located in Aimel District, East Lombok Regency, NTB. The focus of this journal issue is how to evaluate the implementation of the curriculum and the obstacles encountered in evaluating the implementation of the curriculum. In this assessment the author uses a qualitative descriptive research type. with three stages of data collection namely, (1) observation (observation), (2) interview (interview), and (3) documentation. The research data collection method uses non-statistical analysis suitable for descriptive data or structural data that is not realized in the form of numbers, all data is analyzed using identification, classification, and interpretation. The results obtained are (1) One of the evaluations of the implementation of the 2013 curriculum related to teacher readiness in planning, implementation and assessment has been carried out properly. (2) the obstacles encountered are: Teachers still do not understand the assessment in the 2013 curriculum in recapitulating assessments on report cards, preparing lesson plans and the learning process.
Metode Pembelajaran Pendidikan Agama Islam bagi Anak Berkebutuhan Khusus di SLB Negeri 1 Lombok Barat
Authors: Nisa Joharatun , Jumarim Jumarim , Fuadi Abdulloh
Published: May 2023

An important component in learning is the method. The success or failure of a learning activity depends on the method used. Because it is the method that determines how the learning process is carried out in the classroom. The PAI learning method for ABK is a method used by PAI teachers in SLB so that the material presented is easy to understand and understand, so that SLB students can implement their understanding in everyday life. This study aims to identify and analyze the PAI learning method for children with special needs at SLB Negeri 1 Lombok Barat for the types of disabilities who are blind, deaf, mentally retarded and physically disabled. This research is a field research with a qualitative approach. Data collection was carried out using observation, interviews and documentation techniques. The research process lasted for almost 4 months with research subjects being PAI teachers, school principals, curriculum assistants, students with special needs and student guardians. The data analysis technique used is data collection, data condensation, data presentation and drawing conclusions. While the object of research is the learning method of Islamic religious education for Children with Special Needs in the types of disabilities who are Blind, Deaf, Mentally Disabled and Physically Disabled in SLB Negeri 1 West Lombok. The results showed that: the PAI learning method used by PAI teachers for the type of visual impairment is the lecture and question and answer method, the deaf class uses the lecture and demonstration method, the mentally retarded class uses the lecture method and the disabled class uses the lecture and question and answer method.