bluuebunny/crossref_metadata_2025 huggingface dataset:
Chronic cough in post-COVID syndrome: Laryngeal electromyography findings in vagus nerve neuropathy
Authors: García-Vicente Patricia , Rodríguez-Valiente Antonio , Górriz Gil Carmen , Márquez Altemir Reyes , Martínez-Pérez Francisco , López-Pajaro Luis Fernando , García-Berrocal Jose Ramón
Published: March 2023

Background

Despite being a new entity, there is a large amount of information on the characteristics of SARS-CoV-2 infection and the symptoms of the acute phase; however, there are still many unknowns about the clinical features and pathophysiology of post-COVID syndrome. Refractory chronic cough is one of the most prevalent symptoms and carries both a medical problem and a social stigma. Many recent studies have highlighted the role of SARS-CoV-2 neurotropism, but no studies have demonstrated vagus nerve neuropathy as a cause of persistent chronic cough or other COVID-19 long-term effects.

Objective

The main objective was to assess the involvement of the vagus nerve neuropathy as a cause of chronic cough and other post-COVID syndrome symptoms.

Material and methods

This was a single-center observational study with prospective clinical data collected from 38 patients with chronic cough and post-COVID-19 syndrome. Clinical characteristics and laryngeal electromyographic findings were analyzed.

Results

Clinical data from 38 patients with chronic cough after 12 weeks of the acute phase of COVID-19 infection were analyzed. Of these patients, 81.6% suffered from other post-COVID conditions and, 73.6% reported fluctuating evolution of symptoms. Laryngeal electromyography (LEMG) of the thyroarytenoid (TA) muscles and cricothyroid (CT) muscles was pathological in 76.3% of the patients. Of the patients with abnormal LEMG, chronic denervation was the most frequent finding (82.8%), 10.3% presented acute denervation signs, and 6.9% presented myopathic pattern in LEMG.

Conclusions

LEMG studies suggest the existence of postviral vagus nerve neuropathy after SARS-CoV-2 infection that could explain chronic cough in post-COVID syndrome.
Estimation of bargaining effect in the decision of monetary compensation of executive in investment bank: Evidence from China
Authors: Yu Lina , Zhao Hua
Published: March 2023

Though numerous empirical and theoretical studies have been conducted on the determinants and effects of executive compensation, empirical evidence regarding the bargaining effect on the monetary compensation decisions of executives, especially in a large emerging economy such as China, remains scarce. In this study, a two-tier stochastic frontier and endogenous correction model was developed to quantitatively estimate the bargaining effect on the monetary compensation decisions of investment bank executives. Our study is the first to provide comprehensive empirical evidence that bargaining between investment banks and executives in China significantly affects the compensation decisions of executives. In the bargaining process, investment banks are more proficient than executives, and the comprehensive bargaining effect tends to lower the negotiated compensation of executives. The bargaining effect exhibited obvious heterogeneity in the characteristics of executives and investment banks. When these characteristics tend to augment the bargaining power of executives, the negotiated compensation exhibits a limited decrease; when these characteristics augment the bargaining power of investment banks, the negotiated compensation decreases substantially. Our results provide deep insight into factors that determine executive compensation and help compensation designers of investment banks better understand and design executive pay packages.
Class matters in class matters: Education and emancipation in working-class culture: A conversation between Frank and Rita
Authors: Searson Eilis
Published: March 2023

This article is on education and emancipation in working-class culture, examining the use of illustrative language (particularly working-class dialect), as a tool to generate higher (or at least wider) educational exchange. Taking the form of a play script, or as an imagined sequel to Willy Russell’s play Educating Rita ([), this article utilizes the easily digestible format of conversation to explore and illustrate Mikhail Bahktin’s complex ideas on dialogism, and the ideological pedagogical position of Jacques Rancière’s novel The Ignorant Schoolmaster ([1989] 1999). We see Rita become academically educated, and as the narrative develops, the idea of what is meant when we say the word ‘culture’ is constantly challenged. Through exploring social culture in working-class communities, this narrative examines how a ‘lack’ of academic awareness has the potential to lead to a social state of intellectual undress: one that disarms and excites information exchange.
Refugees Welcome? Illustrative storytelling to challenge apathy towards refugees
Authors: Chalabi Hayfaa
Published: March 2023

The illustrator and storyteller Hayfaa Chalabi writes and draws about what kind of design the Migration Board uses to visualize the asylum process. She tells about her own asylum experience and the roles that refugees are forced into. The work becomes a place for memory and history writing where Chalabi tries to understand how to document a process that is prohibited to be documented by the person undergoing it. How and why is the same emotion, such as fear, expressed and processed differently depending on one’s possibilities or impossibilities? This essay therefore aims to explore the tool of illustrative storytelling to challenge governmental restrictions faced by refugee narratives in Sweden. This exploration is done through the study of stereotypes that stigmatize the refugee’s identity. The figure of the refugee is often shaped by the visual representation one consumes via mass media and the words one hears in political debates and social discourse. Refugees are often portrayed as immigrants and nothing but immigrants, faceless victims on news and often de-named suffering people drowning in some ocean. This portrayal makes the humanity of the refugee invisible. A human who has a face, a name, a past, a story beyond his/her refugee story and most importantly an identity and rights.
‘Kalakarm Curriculum’: How can illustration facilitate art in education?
Authors: Gupta Siddhi
Published: March 2023

This article elucidates the journey of the author as an illustrator and educator in the Indian art education landscape, pivoted around the case study of the project called ‘Kalakarm Curriculum’. The author enquires how these roles guide her decisions to develop a distributable resource that can make art education possible in the classroom. A vital part of the process is the primary research conducted at government and low-income private schools in Delhi, India, which provides the necessary constraints to limit the scope of the large issue of art education in India into a workable brief. The project is anchored around the aspirations and challenges of educators who teach different subjects to different age groups, mapped through conversations, observations and the method of workshops. Illustration is used to document the project, communicate its intention, as a process to make meaning and to create the resource that can equip educators to be able to achieve art in education. The end of the project is education – a particular imagination of art education – to make it accessible and transferrable first from the author to the educators and then from the educator to the learners.
Why the smell of metal could shed a tear and other sensorial narratives
Authors: Sarkar Jhinuk
Published: March 2023

Sensory experiences build our worlds, yet in illustration as a practice and subject we often focus so much on the visual stimuli and materiality around us to inform our image-making. Why have we not focused on mediating our range of senses to form a supercharged version of our image-making tools? We live in a time and world that can often be an assault on the senses. But how are these informed and what purpose do they serve in education to help communicate ideas in illustration practices? How can senses be subverted to rejuvenate creative processes? How do senses inform our identity, our memories, nostalgia and in turn, our creative practices? This article is an attempt to explore these questions through examples in Jhinuk Sarkar’s research and practice as an educator and illustrator.
Left Paraduodenal Hernia - A Rare Case of Chronic Abdominal Pain
Authors: Santhosh Puthiya Veettil  , Abhijith Krishna Sasikumar  , Priyanka Mittra  , Abu Anil John  , Indrajith Sushruthan
Published: March 2023

A 48-year-old female, known to be diabetic and hypertensive presented with chronic intermittent abdominal pain in the left upper quadrant for 2 years. The ache was dull and colicky, which was on and off in nature. It has been worsened in the previous 2 months and sometimes associated with nausea and diarrhoea during the onset. She also reported that pain increases during food intake and sometimes it was radiating to the left lumbar region. There was no history of other associated symptoms and no history of any abdominal surgeries. Family history were unremarkable.

On examination patient was alert, conscious and oriented with normal vitals. Per abdomen was soft and distended, mild tenderness over epigastrium and left hypochondrium. There was no guarding or rigidity, no mass palpable or organomegaly. Other systems were within normal limits and laboratory tests showed normal findings.

Patient had taken USG abdomen initially and it was found to be normal. Later CECT abdomen taken which showed cluster of bowel loops seen in continuation with proximal jejunal loops in the region of anterior pararenal space on left side, which was suggestive of paraduodenal hernia. Small bowel barium study also done which showed cluster of jejunal loops on the left side of upper abdomen.
Applications of MIP in electronic devices, focusing on use in biosensors
Authors: MASTROROCCO FABRIZIO
Published: March 2023

Molecular imprint polymer (MIP) based sensors are now widely used and actively proposed as selective absorbent steps in analytical procedures. The previous use of MIPs was that of classic solid phase extraction cartridges, which fortunately led to successful commercially available products (e.g. for mycotoxins). It has recently evolved into the realization of synthetic approaches that produce MIP under more controlled conditions. The use of metallic, inorganic, magnetic or carbon-based nanomaterials as support material for MIPs certainly offers other options and added value depending on the approach used. One of the objectives of this review is a general overview of the types of sensors present such as: Capacitive sensors, Chemiresistor, Field effect transistor of chemical (CHEMFET), Electrochemical sensors, Piezoelectric biosensors, SPR biosensors, etc. The use of multiple detection approaches and the low cost of the devices result in on-site detection of contaminants such as in food, environmental, etc. with unprecedented sensitivity and selectivity.
Development of Mangrove Ecotourism Based on the Tourist Perspective in Lembung Village, Indonesia
Authors: FARID Akhmad , ARISANDI Apri , FARIDY Akhmad Farhan , PRIYANTO Moh. Wahyudi
Published: March 2023

Ecotourism development can be carried out using the Importance Performance Analysis (IPA) method. The community perception of ecotourism is very important in its development with the hope that involvement in the management will increase business opportunities and income. Furthermore, the community can preserve local arts and culture, as well as reduce the destruction of mangrove forest areas. The perception of tourism objects is very important in developing the Lembung Mangrove Ecotourism, especially the improvement of infrastructures such as suspension bridges and cleaning facilities. The recommendations for development strategies include (1) completing the supporting infrastructure for natural tourism activities, such as roads, bridges, cleaning facilities, and others. (2) carrying out intensive promotions (3) making special policies in the development of ecotourism, (4) synergizing with traditional arts and culture, as well as (5) empowering local communities in its activities. The Lembung Mangrove Ecotourism has a good natural potential as a tourist destination, and the availability of a fairly dense mangrove forest is the main factor for visit to this place. Therefore, this study aims to analyze the level of tourists' satisfaction using the Importance Performance Analysis (IPA) method, and to determine the Lembung Mangrove Ecotourism Development Strategy.
Tennis Tournaments from the Perspective of Sport Tourism
Authors: BANCIU Alexandru-Nicolae , POPIRLAN Claudiu-Ionut , COSMA Germina
Published: March 2023

Tourism development over the last years led to an increase in the number of sport events attendees and, on the other hand, the sport events expansion generated the growth of sport related tourism. Sport tourism is a meaningful branch of overall tourism referring to the individuals participating in sport events both actively and passively. Referring to tennis tournaments, there has been a constant increase in media publicity, advertising space for the sponsors and the number of spectators. Thus, tennis, as a sport and a touristic product, has a significant contribution in attracting tourists and in regional development. Long-term development strategies should consider the socioeconomic traits of tennis related tourism.
Tourists’ Hotel Booking Preferences Changed by the COVID-19 Outbreak
Authors: RODYU Sauwanee , CHEABLAM Onanong , NANTAVISIT Nuttaprachya , LING Yang
Published: March 2023

This study aims to identify the characteristics and behaviors of Thai tourists during the pandemic, to investigate the marketing factors in tourism affecting their hotel reservations during the pandemic, and to analyze which marketing factors in tourism have affected their decisions on hotel reservations during the pandemic. Online questionnaires were used to collect data from 385 people. The data was analyzed by descriptive statistics and a confirmatory factor analysis (CFA), while the hypotheses were tested by inferential statistics. The results indicated that Thai tourists considered significant factors in tourism marketing. It included hotel products, room rates, reservation channels, promotions, personnel, features, and services. Furthermore, the hypothesis test indicated that Thai tourists had different hotel reservation behaviors during the pandemic. Gender, age, region, occupation, monthly income, travel goal, accommodation type, length of stay, travel companion, and reservation channel played a statistically significant role at 0.05. Therefore, this study will support hoteliers in planning their strategy to handle situations during the pandemic and prepare for another health crisis in the future. Furthermore, it will benefit the hotel industry by showing ways to develop and improve their products and services to meet tourist demand during a pandemic.
The Impact of Marketing Mix Elements on Tourist's Satisfaction towards Five Stars Hotel Services in Dubai during COVID-19
Authors: JAHMANI Ashraf , JAWABREH Omar , ABOKHOZA Reneh , ALRABEI Ali Mahmoud
Published: March 2023

Purpose: Tourist satisfaction measures the prosperity of a business and tourism sector. If there are many satisfied tourists, the tourism sector will profit, but if there are many less satisfied tourists, the tourism sector will lose money. Therefore, it is necessary to know the factors that affect tourist satisfaction. This study aims to develop and implement a method for five-star hotels to identify attributes that will increase tourists' satisfaction during the pandemic.

Method: The study used 100 tourists in Dubai as respondents who were selected randomly at five-star hotels. The results showed no impact of all marketing mix elements on tourist satisfaction except the physical evidence of the COVID-19 pandemic.

Outcomes: The results of this study indicated that the COVID-19 pandemic influenced five-star hotel services in Dubai and that the marketing mix elements used by the hotels are an important factor in tourist satisfaction. In conclusion, Dubai must understand the importance of a marketing mix to fulfil tourist satisfaction and improve the service that makes it more significant in the tourism industry.

Originality: Numerous modifying variables impacting the management process have been examined in the literature on complaint management. It is the first study investigating the five-star hotel in Dubai to check the operative services on how to work on tourist satisfaction and determine the impact of marketing mix elements on tourism during the pandemic.
Competitiveness of Milk Production. New Perspectives for Developing a New Direction in Tourism: Dairy Tourism
Authors: YERNAZAROVA Anar , ALYONOVA Karlygash , ANAFIYAYEVA Zhibek , NUKESHEVA Anar NUKESHEVA , DARIBAYEVA Adaskhan , KIZIMBAYEVA Azhar
Published: March 2023

The presence of natural and economic risks in agriculture is inherent in many countries, including the Republic of Kazakhstan, which makes the development of the agricultural sector an urgent issue for agricultural producers, especially now when the integration of agro-tourism, which is a kind of breakthrough for the development of rural industry and the revitalization of rural areas, takes place. Integration of agro-ecological efficiency and agrotourism is also closely connected with the competitiveness of milk production by farms and the development of a new direction "dairy tourism", so the study of the relationship between them is of great importance for the implementation of agro-ecological quality development. Kazakhstan has favorable conditions for the development of dairy tourism sector due to the area of cultivated agricultural land, favorable natural and climatic conditions, large volume of dairy products market, positive trends in economic development of the country and, as a consequence, growth of solvent demand, which makes the dairy sector attractive. The aim of the research is to substantiate theoretical provisions and analyze the impact of agrotourism on the efficiency of dairy production competitiveness management in farms (on the example of the northern region of Kazakhstan).
The Effect of Creativity Skill, Motivation, Locus of Control on Self-Efficiency That Impact on the Success of Culinary Tourism Entrepreneurs in North Sumatra
Authors: SEMBIRING Rasmulia , LUBIS Umi Yusniar , SYAIFUDDIN Syaifuddin
Published: March 2023

The purpose of this study is to obtain an overview of the variablescreativity skills, motivation, locus of control affects the variables of increasing the success of culinary entrepreneurs in North Sumatra through the moderating variable of self-efficacy. In this study, the existing variables are closely related to things that affect the success of entrepreneurs such as creativity skills, motivation, locus of control and self-efficacy as moderating variables, thus influencing the dependent variable, namely increasing entrepreneurial success in running a culinary business in North Sumatra. The research method used in this research is descriptive quantitative research method using path analysis. In this study, the independent variables are related to factors that affect the success of culinary entrepreneurs such as creativity skills, motivation, locus of control and affect the moderating efficacy variables that connect the dependent and independent variables, while the dependent variable is to increase entrepreneurial success in running a culinary business in North Sumatra. , data analysis using AMOS 18 and data taken from data on the number of culinary entrepreneurs in North Sumatra in 2016-2020. Partially, the productivity skill, motivation and locus of control variables have a significant effect on the self-efficacy variable and have a significant effect on the variable increasing the success of culinary entrepreneurs in North Sumatra, while simultaneously the productivity skill, motivation and locus of control variables have an indirect significant effect on the increasing variable the success of culinary entrepreneurs in North Sumatra through self-efficacy variables. Based on the results of the research analysis, the conclusion that can be drawn is that partially productivity skill, motivation and locus of control variables have a significant effect on self-efficacy variables and have a significant effect on variables increasing the success of culinary entrepreneurs in North Sumatra, while simultaneously the productivity skills, motivation and locus of control indirectly has a significant effect on the variable increasing the success of culinary entrepreneurs in North Sumatra through self-efficacy variables.Through the results of research that has been stated that the Productivity skill variable possessed by an entrepreneur in the culinary field in North Sumatra must be able to increase the creative abilities possessed in increasing the innovation of their culinary products by creating a new product or modifying it will be able to increase the motivation of a person.
Performance Evaluation of SWAT-based Model for the Prediction of Potential and Actual Evapotranspiration
Authors:   g, University of Ilorin, PMB 1515, Ilorin, Nigeria, T. Sholagberu Abdulkadir
Published: March 2023

Hydrological models have become an important tool for the efficient management of water resources. However, selection of appropriate models for evapotranspiration (ET) computations in river basins remains challenging to watershed managers, especially in data-scarce regions. The performance of Soil and Water Assessment Tool (SWAT)-based model for the prediction of potential and actual evapotranspiration (PET and AET) of OgunOshun river basin, Nigeria was investigated. Spatial and meteorological data was applied in setting up Mapwindow SWAT model. The three existing methods: Penman-Monteith, Priestly-Taylor (radiation-based) and Hargreaves (temperature-based), available in SWAT-were applied for the evaluation of PET and AET using soil, topographic, land-use and meteorological data as input parameters. The model results show a good correlation between the simulated and observed dataset as shown by Nasch-Sucliffe efficiency and coefficient of determination values. For the 30 year-simulation period, the predicted average PET values for PenmanMonteith, Priestley-Taylor and Hargreaves methods were 1791.516, 1684.597 and 1724.563 mm with corresponding standard deviation values of 89.322, 53.824 and 77.867 mm, respectively. The analysis indicated that Penman-Monteith and Hargreaves methods yielded almost the same results, while Priestly-Taylor method slightly differs, which establishes that it is not very suitable for arid/semi-arid regions. The study could be beneficial to watershed managers in addressing climate-related problems and for sustainable water resource management. KEYWORDS: SWAT, Potential evapotranspiration, Actual evapotranspiration, Watershed.
The cardinality of orthogonal exponentials of planar self-affine measures with two-element digit set
Authors: Wang Qi , Ai Dan
Published: March 2023

Let

μ

M
,
D

{{\mu_{M,D}}}

be the planar self-affine measure determined by an expanding integer matrix

M
∈

M
2

⁢

(
ℤ
)

{M\in M_{2}(\mathbb{Z})}

and a two-element digit set

D
⊂

ℤ
2

{D\subset\mathbb{Z}^{2}}

. It has been shown that the spectral or non-spectral problem on

μ

M
,
D

{\mu_{M,D}}

is only related to

trace
⁡

(
M
)

:=

r
1

{\operatorname{trace}(M):=r_{1}}

and

det
⁡

(
M
)

:=

r
2

{\det(M):=r_{2}}

.
In the case when

M
∈

M
2

⁢

(
ℤ
)

{M\in M_{2}(\mathbb{Z})}

is an expanding matrix and

r
1
2

=

3
⁢

r
2

{r_{1}^{2}=3{r_{2}}}

,

r
2

∈

2
⁢
ℤ

+
1

∖

{

±
1

}

{{r_{2}}\in 2\mathbb{Z}+1\setminus\{\pm 1\}}

, the Hilbert space

L
2

⁢

(

μ

M
,
D

)

{L^{2}(\mu_{M,D})}

contains at most a finite number of orthogonal exponentials, and

μ

M
,
D

{{\mu_{M,D}}}

is a non-spectral measure. The remaining problem
in this case is to determine the best upper bound on the cardinality of orthogonal exponentials in the Hilbert space

L
2

⁢

(

μ

M
,
D

)

{L^{2}(\mu_{M,D})}

.
In the present paper, we further the above research to show that there are at most 16 mutually orthogonal exponentials in the corresponding Hilbert space, and the number 16 is the best upper bound. This completes the non-spectrality of self-affine measures in the above case.
𝐿𝑝(⋅) − 𝐿𝑞(⋅) estimates for convolution operators with singular measures supported on surfaces of half the ambient dimension
Authors: Urciuolo Marta , Vallejos Lucas
Published: March 2023

Let

α
i

\alpha_{i}

,

β
i

>
0

\beta_{i}>0

,

1
≤
i
≤
n

1\leq i\leq n

, and for

t
>
0

t>0

and

x
=

(

x
1

,
…
,

x
n

)

∈

R
n

x=(x_{1},\dots,x_{n})\in\mathbb{R}^{n}

, let

t
⋅
x

=

(

t

α
1

⁢

x
1

,
…
,

t

α
n

⁢

x
n

)

,

t
∘
x

=

(

t

β
1

⁢

x
1

,
…
,

t

β
n

⁢

x
n

)

,

t\cdot x=(t^{\alpha_{1}}x_{1},\dots,t^{\alpha_{n}}x_{n}),\quad t\circ x=(t^{\beta_{1}}x_{1},\dots,t^{\beta_{n}}x_{n}),

and let

α
=

α
1

+
⋯
+

α
n

,

∥
x
∥

α

=

∑

i
=
1

n

|

x
i

|

1

α
i

.

\alpha=\alpha_{1}+\dots+\alpha_{n},\quad\lVert x\rVert_{\alpha}=\sum_{i=1}^{n}\lvert x_{i}\rvert^{\frac{1}{\alpha_{i}}}.

Let

φ
1

,
…
,

φ
n

\varphi_{1},\dots,\varphi_{n}

be real functions in

C
∞

⁢

(

R
n

∖

{
0
}

)

C^{\infty}(\mathbb{R}^{n}\setminus\{0\})

such that

φ
=

(

φ
1

,
…
,

φ
n

)

\varphi=(\varphi_{1},\dots,\varphi_{n})

is a homogeneous function with respect to these groups of dilations, i.e.,

φ
⁢

(

t
⋅
x

)

=

t
∘
φ

⁢

(
x
)

\varphi(t\cdot x)=t\circ\varphi(x)

.
Let

γ
>
0

\gamma>0

and let 𝜇 be the Borel measure in

R

2
⁢
n

\mathbb{R}^{2n}

given by

μ
⁢

(
E
)

=

∫

χ
E

⁢

(
x
,

φ
⁢

(
x
)

)

⁢

∥
x
∥

α

γ
−
α

⁢

d
x

.

\mu(E)=\int\chi_{E}(x,\varphi(x))\lVert x\rVert_{\alpha}^{\gamma-\alpha}\,dx.

Let

T
μ

⁢
f

=

μ
∗
f

T_{\mu}f=\mu\ast f

,

f
∈

S
⁢

(

R

2
⁢
n

)

f\in S(\mathbb{R}^{2n})

.
In this paper, we study the boundedness of

T
μ

T_{\mu}

from

L

p
⁢

(
⋅
)

⁢

(

R

2
⁢
n

)

L^{p(\,{\cdot}\,)}(\mathbb{R}^{2n})

into

L

q
⁢

(
⋅
)

⁢

(

R

2
⁢
n

)

L^{q(\,{\cdot}\,)}(\mathbb{R}^{2n})

for certain variable exponents

p
⁢

(
⋅
)

p(\,{\cdot}\,)

and

q
⁢

(
⋅
)

q(\,{\cdot}\,)

.
Inverse nodal problem for diffusion operator on a star graph with nonhomogeneous edges
Authors: Durak Sevim
Published: March 2023

In this study, a diffusion operator is investigated on a star graph with
nonhomogeneous edges. First, the behaviors of sufficiently large eigenvalues
are learned, and then the solution of the inverse problem is given to determine
the potential functions and parameters of the boundary condition on the star
graph with the help of a dense set of nodal points and
to obtain a constructive solution to the inverse problems of this class.
TMT-based comprehensive proteomic profiling identifies serum prognostic signatures of acute myeloid leukemia
Authors: Zhang Wei , Liu Bei , Wu Shiwen , Zhao Li
Published: March 2023

Acute myeloid leukemia (AML) is classified into favorable-risk, intermediate-risk, and poor-risk subtypes. This study aimed to compare the serum proteomic signatures of the three AML subtypes and identify prognostic biomarkers for AML. Serum samples from patients with favorable-risk (n = 14), intermediate-risk (n = 19), and poor-risk AMLs (n = 18) were used for the analysis of tandem mass tag (TMT) labeling-based quantitative proteomics. Comparative analysis was performed to identify differentially expressed proteins (DEPs) between groups. Prognostic proteins were screened using binary logistics regression analysis. TMT-MS/MS proteomics analysis identified 138 DEPs. Fumarate hydratase (FH), isocitrate dehydrogenase 2 (IDH2), and enolase 1 (ENO1) were significantly upregulated in poor-risk patients compared with favorable-risk patients. ELISA assay confirmed that patients with poor-risk AMLs had higher levels of IDH2, ENO1, and FH compared with intermediate-risk AML patients. Logistics analysis identified that proteins 3-hydroxyacyl-CoA dehydrogenase type-2 (HADH, odds ratio (OR) = 1.035, p = 0.010), glutamine synthetase (GLUL, OR = 1.022, p = 0.039), and lactotransferrin (LTF, OR = 1.1224, p = 0.016) were associated with poor prognosis, and proteins ENO1 (OR = 1.154, p = 0.053), FH (OR = 1.043, p = 0.059), and IDH2 (OR = 3.350, p = 0.055) were associated with AML prognosis. This study showed that AML patients had elevated levels of FH, IDH2, ENO1, LTF, and GLUL proteins and might be at high risk of poor prognosis.
Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives
Authors: Zhang Cheng , Chen Guoming , Tang Guoyi , Xu Xiaoyu , Feng Zixin , Lu Yuanjun , Chan Yau-Tuen , Wu Junyu , Chen Yuanyuan , Xu Lin , Ren Qing , Yuan Hongchao , Yang Dong-Hua , Chen Zhe-Sheng , Wang Ning , Feng Yibin
Published: March 2023

For hundreds of years, the drug discovery and development industry has aimed at identifying single components with a clear mechanism of action as desirable candidates for potential drugs. However, this conventional strategy of drug discovery and development has faced challenges including a low success rate and high development costs. Herein, we critically review state-of-the-art drug discovery and development based on multi-component Chinese medicine formulas. We review the policies and application status of new drugs based on multi-component Chinese medicines in the US, China, and the European Union. Moreover, we illustrate several excellent cases of ongoing applications. Biomedical technologies that may facilitate drug discovery and development based on multi-component Chinese medicine formulas are discussed, including network pharmacology, integrative omics, CRISPR gene editing, and chemometrics. Finally, we discuss potential problems and solutions in pre-clinical and clinical research in drug discovery and development based on multi-component Chinese medicine formulas. We hope that this review will promote discussion of the roles of multi-component Chinese medicine formulas in the discovery and development of new drugs for the treatment of human diseases.
Photographic Process as Desire
Authors: Morgan Nicholas C.
Published: March 2023

Between 1986 and his death from AIDS-related causes in 1989, the Boston- and Jersey City–based photographer Mark Morrisroe produced a series of cameraless photographs with heterogenous material including fabric, pornography, and X-rays. This essay argues that these photograms move away from a dominant understanding of photography that celebrates stasis, legibility, and indexicality in favor of one concentrating on activity. Morrisroe’s photograms cast the photograph as a process: the image unfixable and always under development, its matter flexing, sputtering, and shifting over time. For Morrisroe, this project was inextricable from an understanding of desire itself as processual. The essay positions Morrisroe’s processual and desirous conception of photography as an instance of what has recently been theorized as queer formalism’s capacity to galvanize queer politics and resist social violence. Morrisroe’s formal experimentation with the medium and unorthodox use of darkroom materials countered mainstream, pathos-ridden representations of AIDS and imagined alternatives to the epidemic’s fragmentation of queer worldmaking projects. Through intertextual readings with Morrisroe’s contemporary Hervé Guibert, the essay shows how Morrisroe’s anti-indexical and processual cameraless photography demonstrates the medium’s potential as a vehicle for currents and transmissions knitting together spectators, bodies, and queer communities in flow.
Synthesis and characterization of loaded nano/zinc oxide composite hydrogels intended for anti-mold coatings on bamboo
Authors: Huang Qiuli , Du Chungui , Hua Yating , Zhang Jingjing , Peng Rui , Yao Xiaoling
Published: March 2023

This study investigated the antibacterial activity of nano-zinc oxide (ZnO) composite hydrogels on the types of mold organism that commonly affect bamboo. The nano-ZnO was produced via the in situ method in poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAm-co-AAc)) hydrogel. The structures and properties were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), differential scanning calorimeter (DSC), equilibrium swelling ratio (ESR), deswelling and swelling tests, and antimicrobial activity. The nano-ZnO particles were monodispersed in the P(NIPAm-co-AAc) hydrogel. The concentration of the nano-ZnO was higher in the ZnO/P(NIPAm-co-AAc) hydrogel than in the ZnO/PNIPAm hydrogel. The swelling properties in the ZnO/P(NIPAm-co-AAc) hydrogel were more favorable than those of the ZnO/PNIPAm hydrogel, while the deswelling properties were more favorable in the ZnO/PNIPAm hydrogel. The hydrogels that contained more ZnO nanoparticles demonstrated greater antimicrobial properties against Trichoderma viride and Penicillium citrinum of bamboo, while the all of the hydrogels had much less antimicrobial activity against Aspergillus niger.
Perilaku Baik itu Mudah atau Sukar? Representasi dalam Youtube Tontonan Anak Nussa dan Rara
Authors: Fanshoby Muhammad , Hasbullah Muhammad Najmudin , Hermansah Tantan
Published: March 2023

Tontonan bagi anak di media sosial Youtube masih minim edukasi. Padahal saat ini, anak-anak memanfaatkan media sosial sebagai tontonan mereka. Beberapa studi menyebutkan bahwa perilaku anak dipengaruhi oleh apa yang mereka tonton. Dengan begitu, youtube menjadi salah satu platform media sosial yang memengaruhi perilaku anak. Penelitian ini akan menganalisis Nilai Akhlak dalam Media Sosial Youtube Nussa dan Rara, Episode Baik itu Mudah dengan menggunakan Pendekatan Representasi Stuart Hall. Tujuan penelitian ini untuk menjawab research questions bagaimana representasi akhlak anak pada video Nussa dan Rarra dari aspek budaya, bahasa, dan makna. Hasilnya menunjukkan bahwa video animasi Nussa dan Rarra merepresentasikan akhlak anak berdasarkan unsur budaya, bahasa dan makna yang sesuai dengan ajaran Islam. Itu didapat dari temuan pada 3 shot dalam video episode “Baik itu Mudah”. Video ini di upload Nussa Official pada 23 Mei 2019 yang berdurasi 06.53 menit dengan jumlah tayang 66.954.922  dan likes 451 ribu
Analisis Proses Interaksi dan Perilaku Komunikasi dalam Kelompok Tarekat Tijaniyah di Zawiyah Serang Kabupaten Bekasi
Authors: Pratiwi Ellya , Ismail Asep Usman , Sukmawati Lilis
Published: March 2023

Penelitian ini bertujuan untuk menganalisis proses interaksi dan perilaku komunikasi dalam kelompok tarekat Tijaniyah di Zawiyah Serang Kabupaten Bekasi. Pesan-pesan yang dipertukarkan dalam proses interaksi kelompok dapat membentuk peran dan kepribadian anggota kelompok serta karakter atau sifat kelompok secara keseluruhan. Proses interaksi dan dinamika komunikasi kelompok tarekat Tijaniyah ini dianalisis berdasarkan teori analisis proses interaksi oleh Robert Bales. Penelitian ini menggunakan pendekatan kualitatif dan bersifat deskriptif. Hasil penelitian menunjukkan bahwa proses interaksi pada kelompok Tijaniyah di Zawiyah Serang Kabupaten Bekasi membentuk peran dan kepribadian anggota kelompok secara keseluruhan. Muqaddam yang berperan sebagai pemimpin kelompok lebih dominan secara signifkan dibandingkan peran pemimpin sosioemosional. Baik para anggota kelompok (ikwhan Tijaniyah) maupun muqaddam menunjukkan tindakan positif yang dapat dilihat kategori pesan dan situasi komunikasi. Proses interaksi tersebut membuat permasalahan komunikasi pada kelompok ini secara umum terkendali dengan baik.
Twitter Sebagai Media Speak Up Perempuan Dalam Kasus Pelecehan Seksual
Authors: Marundha Ainy Sucianti , Rahmiputri Aisha Andari , Fatina Nadiah Nur , Hasna Safira , Seyma Qoryna Noer
Published: March 2023

Sexual harassment is not something that has just been heard or recently talked about. Sexual harassment is still a threat and taboo to be discussed and is not an easy thing to get rid of. This often happens to women in Indonesia, both in public places and on social media. However, along with the presence of social media, women can take advantage of the forum as a place where they express their opinions to voice issues of empowering women. Therefore, the objective of this research is to find out women victims of sexual harassment in utilizing social media Twitter as a forum for expression related to sexual harassment cases. This research used theory of feminism, cyberfeminism, sexual harassment and the relation between technology and women. This research used qualitative approach and constructivism strategy. The data was collected through in-depth interview with female victims of sexual harassment who dare to speak up on Twitter social media.
Dakwah Digital dalam Meme Ajakan Shalat Jum’at: Perspektif Semiotika
Authors: Sunaryanto Sunaryanto
Published: March 2023

This study analyzes the meaning of digital da'wah in the Friday prayer invitation meme. This research was completed with a qualitative research approach with semiotic analysis which is part of the textual analysis of mass media. The findings of the research are digital da'wah signs in memes asking for Friday prayers such as caps, white koko clothes, mics, headscarves, Al-Qur'an etc. The digital da'wah signifiers in the meme are Rhoma Irama, Joko Widodo, Prabowo Subianto, beautiful women, etc. The signified digital da'wah memes are piety, faith, politicization of religion, and political campaigns. The denotation meaning of digital da'wah in the meme is that a good leader even though he is busy does not leave the Friday prayer obligation. Friday prayer should be understood by Muslim men compared to Friday night worship (i.e husband and wife relationship). Its connotative meaning is that the Friday prayer is understood as an attempt to gain political masses. Friday prayers are considered as a way to be handsome in this world only and not handsome in the hereafter. The conclusion is that digital da'wah in the invitation to Friday prayer can be interpreted in three contexts, namely Islam, culture and politics.
Makna Positif dalam Foto Selebgram Anak (Semiotika dalam Foto Instagram @aishwa_nahla, @ayashaputri dan @retnohening)
Authors: Khaidar Muhammad , Al Hakim Taufiq
Published: March 2023

Media sosial saat ini menjadi sarana komunikasi dalam bertukar pesan dengan yang lainnya. Salah satu cara bertukar pesan di media sosial adalah dengan menggunakan foto. Foto yang diunggah tentu memiliki makna yang ingin disampaikan oleh orang tua selebgram anak kepada followersnya. Berdasarkan konteks diatas, masalah penelitian tentang makna foto dalam status selebgram anak, karena saat ini terjadi fenomena dimana orang tua mengunggah foto anaknya di media sosial, terutama di Instagram. Penelitian ini bertujuan untuk mengetahui makna foto dalam status selebgram anak. Foto yang akan diteliti adalah foto dengan konten sharenting atau berbagi informasi tentang cara mendidik anak di Instagram. Selebgram anak yang menjadi objek penelitian ini adalah Aishwa (@aishwa_nahla), Ayasha (@ayashaputri) dan Kirana (@retnohening). Metode penelitian yang digunakan adalah kualitatif deskriptif, menggunakan teori pemaknaan foto atau semiotika Roland Barthes yaitu denotasi, konotasi dan mitos. Foto yang dipilih menggunakan purposive sampling, dengan syarat dan ketentuan sesuai kebutuhan penelitian. Peneliti mengambil tiga foto (sharenting) dari setiap selebgram anak, jadi ada sembilan foto pada penelitian ini. Hasil penelitian menunjukkan bahwa makna foto dalam status selebgram anak memiliki informasi yang positif bagi followers selebgram anak. Bahwa setiap orang tua memiliki cara terbaiknya dalam mendidik anak sesuai dengan kebutuhan anak dan orang tua.
Ekologi Media Radio 95,5 RAS FM dalam Mempertahankan Eksistensinya di Era Media Online
Authors: Trilaksono Iskandar
Published: March 2023

Penelitian ini bertujuan untuk melihat bagaimana strategi radio 95,5 RAS FM dalam mempertahankan eksistensinya di era media online ditinjau dari jenis isi media (types of content), jenis khalayak siaran (types of audien), dan modal (capital). Penlitian ini menggunakan teori ekologi media oleh Dimmick dan Rothenbuhler. Teori ini memberikan asumsi bahwa media dapat bertahan jika memperhatikan tiga faktor penting, yaitu types of content, types of audience, dan capital dengan metode kualitatif deskriptif. Hasil penelitian menunjukkan berdasarkan types of content RAS FM memiliki program yang up to date yang dikemas dalah 6 jenis program dan terbagi ke dalam 13 konten siaran. Berdasarkan types of audiens RAS FM memiliki segmen audiens secara geografis di Jakarta. Secara demografis, segmen audiens RAS FM di dominasi oleh perempuan dengan rentang usia 20-50 tahun serta berasal dari Socio Economyc Status (SES) B,C, dan A. Secara psikografis, segmen audiens RAS FM adalah keluarga muslim. Berdasarkan Capital RAS FM memiliki modal awal dari umat Islam dan pendirinya; modal finansial saat ini berasal dari pendapatan iklan dan donasi para filantropis Islam; modal Sumber Daya Manusia (SDM) yang memiliki kapabilitas; dan modal fasilitas yang memadai untuk siaran.
Comportamento de adolescentes do sexo feminino acerca da utilização de preservativos
Authors: Oliveira Alana dos Santos , Farre Anny Giselly Milhome da Costa , Santana Ingrede Tatiane Serafim , Santos Marks Passos , Felix Paulo Thomaz Oliveira , Matos Ana Liz Pereira de
Published: March 2023

Objetivo: caracterizar o conhecimento e a prática acerca da utilização de preservativos por parte de adolescentes do sexo feminino, estudantes do ensino médio de uma escola da rede estadual do interior de Sergipe, Brasil.
Materiais e método: pesquisa de corte transversal, realizada em uma escola da rede pública localizada no interior do Estado de Sergipe, Região Nordeste do Brasil. A coleta de dados ocorreu em fevereiro e março de 2017, na escola com o maior número de adolescentes matriculados do Estado.
Resultados: entre as 94 participantes do estudo, a média de idade foi de 17,3 anos (DP = 1,2); a maioria das adolescentes referiu renda familiar mensal de até um salário-mínimo (61,3 %). A religião predominante foi a católica (74,5 %). Apenas 4,3 % das adolescentes afirmaram ter filho e uma delas encontrava-se gestante (1,1 %). Quanto à iniciação sexual, 51,1 % das adolescentes participantes referiram não ter tido as primeiras relações sexuais, enquanto 48,9 % apresentavam vida sexual ativa. A maior frequência de relações sexuais e uso de preservativo entre as adolescentes foi encontrada entre aquelas que referiram a ingesta de bebidas alcoólicas (40 [42,5 %]; p < 0,05). Sobre preservativos, 92,6 % das adolescentes conheciam e já haviam tido contato com o preservativo masculino, enquanto apenas 62,8 % conheciam e tinham visualizado o feminino.
Conclusões: as adolescentes apresentam conhecimento frágil sobre preservativos e adotam prática sexual insegura; portanto, é fundamental o desenvolvimento de estratégias de educação sexual que visem melhorar o conhecimento e as habilidades das adolescentes sobre o tema.
Resistencias, re-existencias y prácticas chamánicas: las poéticas y políticas de una visión contemporánea
Authors: Langdon Jean , Laffay Tom , Maniguaje-Yaiguaje Pablo
Published: March 2023

Los actuales siona son descendientes de los 18,000 tucanos occidentales que ocuparon las cuencas de los ríos Caquetá, Putumayo y Aguarico en Colombia y Ecuador. Debido a las transformaciones socio-económicas de la región y a la pérdida del territorio ancestral, cuando la autora antropóloga inició sus investigaciones entre los siona de Buenavista en los setentas, no había curacas siona que guiaran las tomas de yajé. No obstante, en los años siguientes, los siona retomaron las tomas colectivas de yajé para fines espirituales y políticos. Actualmente, el “taita”, nombre actual para referir al especialista ritual, es reconocido como la autoridad tradicional y el defensor del territorio sagrado frente a la violencia armada y las actividades petroleras en la región. Este artículo presenta una narrativa que contó el Taita Pablo Maniguaje Yaiguaje a la guardia indígena después de una toma de yajé para introducirlos al mundo invisible del territorio. Con base en su análisis, se argumenta que las prácticas chamánicas contemporáneas de los indígenas siona son una demostración de su resistencia y re-existencia. La narrativa de Taita Pablo demuestra la continuidad de la poética y de la política del papel del chamán.
“Quem chegou primeiro?” Deslocamento de ribeirinhos na implantação da usina hidrelétrica de Santo Antônio (RO)
Authors: Rocha Daniete Fernandes , Araújo Jane Aparecida Nunes de Araújo , Campos Mauro Macedo Campos , Costa Luciana Assis Costa
Published: March 2023

Este artigo analisa o deslocamento dos ribeirinhos para os reassentamentos de Novo Engenho Velho e Riacho Azul, no município de Porto Velho-RO, em função da construção da Usina Hidrelétrica Santo Antônio, no rio Madeira. A pesquisa teve caráter quantitativo/descritivo, com algumas informações qualitativas, a partir de análise documental, entrevistas semiestruturadas e questionários. Compuseram a amostra três representantes da usina e 28 famílias dos reassentamentos. Os resultados mostram uma visão dos representantes da usina associada aos objetivos da política de desenvolvimento de infraestrutura no país. A partir do apoio às novas habitações e às novas atividades produtivas os gestores consideram que propiciaram condições para que os ribeirinhos deslocados mantivessem suas estruturas familiares, de vizinhança e socioeconômicas, embora cientes das mudanças necessárias nesse processo. Na percepção dos antigos ribeirinhos, trata-se de enfrentar o rompimento de um modo de vida organizado às margens do rio, com as consequências de um deslocamento para outros lugares, em que as antigas condições familiares, sociais e econômicas não se reproduzem e as novas condições apresentam diversas fragilidades, em especial as interdições à atividade de pesca, a pior qualidade da terra para agricultura e o funcionamento deficitário dos equipamentos de saúde, educação e saneamento.
Long-term performance of simultaneous measurement of stable isotopes of oxygen and carbon in cellulose with a high-temperature pyrolysis/gas chromatography/isotope ratio mass spectrometry system at the Institute for Geological and Geochemical Research
Authors: Kern Zoltán , Llanos Campana Daniela Maria , Hegyi István Norbert
Published: March 2023

A high-temperature pyrolysis/gas chromatography/isotope ratio mass spectrometry system was established at the Institute for Geological and Geochemical Research in 2013. A dedicated field of application of the system is the simultaneous measurement of stable carbon and oxygen isotope ratios in the cellulose of modern, relict and subfossil plant tissues and sediments. The measurement protocol was fine-tuned during the first year of operation and documented in detail in this report. To quantify the long-term reproducibility of the simultaneous measurement of stable isotopes of oxygen and carbon in cellulose, a 2σ range inferred from repeated measurements of a Quality Assurance standard can be recommended: 0.16 and 0.20‰, for δ13C and δ18O, respectively. An extensive set of samples with known pyrolysis-based δ13C data was analyzed in combustion mode and the paired results were used to assess the necessity of adjustment of the pyrolysis-based δ13C measurements. The variances of the two datasets were not significantly different; the slope (intercept) of the regression was indistinguishable from unity (zero), suggesting that probably owing to the relatively frequent cleaning of the pyrolysis furnace, pyrolysis-based δ13C data neither suffer from a variance bias nor require a specific adjustment.