bluuebunny/crossref_metadata_2025 huggingface dataset:
Endoscopic assisted key-hole surgery for subacute subdural hematoma evacuation in emergency situations
Authors: Sun guo-chen , Li Chong , Tang Hao , Yi Ke-fan , Li Fang-ye , Xu Bai-nan , yu xin-guang
Published: February 2020

Background Endoscopic removal of subacute subdural hematoma is seldom performed, but there is no standard technique till date. We investigated whether a simple endoscopic method is effective for the evacuation of subacute subdural hematoma. Methods A total of 51 patients with subacute subdural hematoma requiring surgery were enrolled in this study. Endoscopic hematoma evacuation was performed through a small bone window for 22 patients. Hematoma evacuation by open surgery was performed in 29 patients. Pre- and postoperative Glasgow coma scale (GCS), operation time, displacement of midline, and intraoperative blood loss were recorded and analyzed. Results The median time from incision to suture completion was 40 min (range: 31.25–43.75 min) for endoscopic group, and 70 min (range: 65–80 min) for open surgery group (P<0.01). The average total blood loss was 50(30-50) ml for endoscopic group, and 250(200-300) ml for open surgery group (P<0.01). No patient showed post-operative re-bleeding in both groups. The mean preoperative mid-line displacement for the two groups was 11.51±3.51mm for study group vs 10.47±2.93mm for control group (P>0.05). Mid-line displacement showed significant improvement on the day after surgery to 5.29±1.91mm for study group vs 6.75±1.37mm for control group (P<0.01). At 1-month follow-up, the midline was normal in both groups. Computed tomography revealed almost no residual hematoma, representing an average evacuation rate of 100% in both groups. The mean preoperative GCS score was 13(12.25,15) for study group vs 13(12,14) for control group(P>0.05). GCS score on the day after the operation was improved to 15 for each patient in endoscopic surgery group, while 15(14,15)in the open surgery group (P<0.01). Conclusions Endoscopic subacute subdual hematoma removal through a small bone window achieved a satisfactory hematoma removal with minimally invasive method when compared to open surgery.
Screening of prognostic biomarkers for Stereotactic Body Radiation Therapy in liver cancer
Authors: Liang Zhenzhen , Sun Hongbin , Yu Binbin , Zhang Xueyuan , Fu Xinxin , Jiang Heya , Liu Lianchang , Liu Xiaodong
Published: February 2020

So far there are still no effective immediate-early markers for assessing the efficacy of Stereotactic Body Radiation Therapy (SBRT). To find effective biomarkers for accurate assessment of the efficacy of SBRT in patients with liver cancer. Patients with liver cancer were included at Ruikang Hospital affiliated to Guangxi Medical University from January 2012 to December 2018. Follow-up was conducted, clinical information and blood samples (before SBRT, before discharge and 2 months after SBRT) were collected. mRNAs profiles were detected by high-throughput sequencing, followed by qPCR verification. The commonly-used serum biomarkers such as AFP, CEA and CA125 shown low prognostic value in distinguishing survival group and death group, indicated by low AUC (less than 0.7) and Yoden indexes (less than 0.5). Based on high-throughput sequencing of test group and qPCR detection of another verification group, we found 16 up-regulated and 12 down-regulated genes after SBRT. Among them, ADIPOR1 and EPB42 showed significantly different between effective and ineffective group after SBRT, ROC suggested that based on the optimal threshold of 0.5838, ADIPOR1 shown a sensitivity of 100% and a specificity of 83.33% to distinguish effective from ineffective group. Similarly, EPB42 had a sensitivity of 75% and a specificity of 100% at the optimal threshold of 1.3817. Thus, ADIPOR1 and EPB42 in whole blood are promising candidates to act as prognostic biomarkers for predication of SBRT outcomes in liver cancer patients.
PECULIARITIES OF ELECTROLYTIC BALANCE IN THE BLOOD OF NEWBORNS WITH KIDNEY DAMAGE DUE TO ASPHYXIA
Authors: Loboda A. M. , Smiyan O. I. , Popov S. V. , Petrashenko V. O. , Loboda D. A.
Published: February 2020

Introduction. The study of the concentration of main electrolytes in serum of blood and erythrocytes in neonates with impaired renal function due to asphyxia is important, because it allows determining violations of their content and balance, tactics of infusion and diuretic therapy. The purpose of the work is explore the features of the content and balance of electrolytes (sodium, potassium, calcium, magnesium) in serum and red blood cells of newborns with disturbance kidney function due to asphyxia.
Materials and methods. The study involved 200 term infants with signs of disturbance kidney function: 100 children who have suffered severe asphyxia, 100 children – with moderate asphyxia. Comparison group consisted of 20 infants without asphyxia at birth. The content of electrolytes determined by emission photometry, also expected ratios in pairs Na/K and Ca/Mg and transmembrane ratio of trace elements.
Results and discussion. The critical period of formation electrolyte imbalances in neonates with impaired renal function due to moderate asphyxia is the early neonatal period, in case of severe asphyxia – all neonatal period. The feature of ischemic renal impairment in newborns is the development of serum hypernatremia and hyperkalemia, hypocalcemia and hypomagnesemia, decrease the ratio of Na/K and increase Ca/Mg. Red blood cell pool of macroelements in case of neonatorum ischemic nephropathy is characterized by the growth of sodium level and deficiency of potassium, calcium and magnesium, as well as growth transmineralisation Na/K ratio and decrease Ca/Mg. Growth transmembrane ratios relative to sodium and magnesium reflects their transport into the cell, and reducing ratios relative potassium and calcium indicates the predominance of these electrolyte transport in the extracellular fluid. Changes in serum and intracellular electrolyte content and balance must be considered during infusion therapy in infants with impaired renal function due to asphyxia.
EFFECTS OF TYPE 2 DIABETES MELLITUS ON CLINICAL AND LABORATORY STATUS OF WOMEN WITH ARTERIAL HYPERTENSION, OBESITY, AND LEFT VENTRICULAR DIASTOLIC DYSFUNCTION
Authors: Kyrychenko N. , Opolonska N. , Stepanets O.
Published: February 2020

Patients with type 2 diabetes mellitus (DM) may develop cardiomyopathy independently of such risk factors as arterial hypertension and coronary heart disease. Myocardial dysfunction in diabetes mellitus may vary from subclinical forms of left ventricular dysfunction to heart failure. It was suggested that diastolic left ventricular dysfunction is one of the earliest signs of myocardial injury in diabetes mellitus and plays a key role in the formation of diabetic cardiomyopathy.
The aim of our study was to evaluate the effect of diabetes on the clinical and laboratory status of women with hypertension, obesity, and left ventricular diastolic dysfunction (LVDD).
Materials and methods. We examined 80 patients aged 40 to 60 years with stage 2, grade II and grade III hypertension, class I–III obesity, grade 1 LVDD and preserved ejection fraction. Depending on the presence or absence of diabetes, the cohort of patients was divided into two groups: patients with diabetes were assigned to group 1 and non-diabetes patients ­­– to group 2. Statistical processing was performed using Statistica for Windows version 6.0.
Results. Patients had tendency to increased body mass index (BMI) in the DM group, but without significant differences. The results of the 6-minute walk test showed a tendency to decreased distance in the group of patients with diabetes. There was an increase in leptin levels and a decrease in adiponectin in patients with diabetes without significant differences. Levels of IL-6, glycosylated hemoglobin, and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) index were significantly higher in the cohort of patients with diabetes (p <0.05).
Conclusions. Women aged 40–60 years with LVDD with hypertension, class I–III obesity and type 2 diabetes mellitus differ from similar cohorts of patients without diabetes with a tendency to increased BMI levels, leptinemia, and decrease in distance of 6-minute walk test, LV ejection fraction and blood adiponectin level; they have significantly higher blood levels of interleukin-6, glycosylated hemoglobin (HbA1c) and HOMA-IR; indicators of diastolic function in the group of patients with diabetes tend to worsen the parameters of diastolic filling of the LV even in grade 1 DD.
COMPARATIVE FEATURES OF OPEN SOURCE SOFTWARE PRODUCTS FOR THE DEVELOPMENT OF AN AUTOMATED BREAST CANCER DIAGNOSTIC PROGRAM
Authors: Kovalev V. , Diachenko Y. , Malyshev V. , Rjabceva S. , Kolomiets O. , Lyndin M. , Moskalenko R. , Dovbysh A. , Romaniuk A.
Published: February 2020

Breast cancer is one of the most common cancer diseases in the world among women. The reliability of histological verification of breast cancer depends on pathologist’s experience, knowledge, his willingness to self-improve and study specialized literature. Digital pathology is also widely used for educational purposes, in telepathology, teleconsultation and research projects. Recently developed Whole Slide Image (WSI) system opens great opportunities in the histopathological diagnosis quality improvement. Digital whole-slide images provide the effective use of morphometry and various imaging techniques to assist pathologists in quantitative and qualitative evaluation of histopathological preparations. The development of software for morphological diagnosis is important for improving the quality of histological verification of diagnosis in oncopathology. The purpose of this work is to find and benchmark existing open-source software for the whole-slide histological images processing. Choosing an open source program is an important step in developing an automated breast cancer diagnosis program.
The result is a detailed study of open-source software: ASAP, Orbit, Cytomine and QuPath. Their features and methods of image processing were analyzed. QuPath software has the best characteristics for extending it with an automated module for the cancer diagnosis. QuPath combines a user-friendly, easy-to-use interface, customizable functionality, and moderate computing power requirements. Besides, QuPath works with whole-slide images with immunohistochemical markers; features implemented in this software allow making a morphometric analysis.
QuPath saves time for a graphical user interface development and provides a scalable system to add new key features. QuPath supports third-party MATLAB and Python extensions.
Organizational and Economic Potential of Joint Engagement of Venture Capital and Business Process Re-engineering in the Marketing Activities of Industrial Enterprises
Authors: Melnyk Leonid Hr. , Derykolenko Oleksandr M. , Matsenko Oleksandr M. , Pasyevin Oleksiy O. , Khymchenko Yurii V.
Published: February 2020

The Ukrainian industry is a strategically important industry that retains the potential to contribute to the rapid development of the national economy. At the same time, this potential can be realized only choosing an innovation vector of the nearest future of the industry. Together with the activation of innovation activity, industrial entrepreneurs face the problem of the fund scarcity, high risks and outdated approaches to the conduct and organization of activities. In these terms, the authors of the article propose to investigate the organizational and economic potential of joint engagement of venture business and reengineering of business processes in the marketing sphere of industrial enterprises. It is marketing activity of industrial enterprises, which is recommended by the authors as the most effective for operative adaptation of the company to radical transformations in outer business-environment. Being in the tight connection with a customer (existing and potential) and its requirements, marketing activity is able to define strategic directions of company development and to implement new regulars of business in everyday company’s activity. Thus, the study analyses organizational principles of venture activity and reengineering business-processes in marketing activity, the relationship between these areas in the organization of innovation activities and common approaches to the development of strategic programs for the development of industrial enterprises under the conditions of sharp transformations in the external business environment. Reengineering business-processes in marketing activity is presented as an innovation, which could be engaged through venture capital, and in the same time, this innovation is able to carry out radical transformations in its organization and business-activity principle. The transformations should be carried out to ensure further effective use of engaged investments and to develop effective innovation activity.
Key words: industrial enterprise, venture activities, marketing activities, re-engineering, business process, organization, resource, strategy, business environment.
Presentación
Authors: Castrillón Castrillón Andrés Alfredo
Published: February 2020

El volumen 11, número 1, de la Revista Colombiana de Ciencias Sociales dispone a la comunidad académica e investigadora una serie de artículos que giran en torno al estudio de fenómenos sociales vinculados a los aportes regionales y nacionales, que han tenido un impacto reciente en el entorno político. Algunas de estas contribuciones tienen una convergencia en los efectos y consecuencias que han ocasionado el conflicto armado y las negociaciones en torno a esta problemática. También hay indagaciones sobre nuevos procesos de constitución de la familia y un estudio sobre el método de desarrollo familiar.
Estudio de la inversión del 10 % de los recursos destinados para el Fondo de Ciencia, Tecnología e Innovación a través del Sistema General de Regalías, Departamento del Caquetá
Authors: Cuéllar Medina Yolanda , Caraballi Cañón John Sebastián , Valderrama Cardozo Carmen Alejandra
Published: February 2020

Son cuantiosos los recursos que se vienen ejecutando a través de proyectos de inversión que deben tener una influencia en la sociedad. En el presente artículo se pretende analizar cómo ha sido la implementación, a través del 10 % del Sistema General de Regalías, del Fondo de Ciencia, Tecnología e Innovación en el Departamento del Caquetá para el periodo 2013-2015, con el fin de evidenciar qué proyectos se están realizando y qué impacto ha generado este sistema en beneficio de la región. Se realizaron entrevistas a los secretarios de planeación de los diferentes municipios del Departamento, al igual que encuestas para conocer la percepción sobre la importancia y ejecución de los recursos de Ciencia Tecnología e Innovación en el Departamento del Caquetá; en total se encuestaron 232 personas, de las cuales se pudo evidenciar que un 40 % tiene conocimiento sobre el Fondo de Ciencia Tecnología e Innovación, mientras que el restante 60 % manifestó no tener conocimiento sobre el tema. Por esta razón se insta a la Gobernación y alcaldías del Departamento del Caquetá para que den a conocer la ejecución de los recursos destinados por el Sistema General de Regalías.
A Rank-Deficient and Sparse Penalized Optimization Model for Compressive Indoor Radar Target Localization
Authors: Tang Van Ha , Nguyen Van-Giang
Published: February 2020

This paper proposes a rank-deficient and sparse penalized optimization method for addressing the problem of through-wall radar imaging (TWRI) in the presence of structured wall clutter. Compressive TWRI enables fast data collection and accurate target localization, but faces with the challenges of incomplete data measurements and strong wall clutter. This paper handles these challenges by formulating the task of wall-clutter removal and target image reconstruction as a joint low-rank and sparse regularized minimization problem. In this problem,  the low-rank regularization is used to capture the low-dimensional structure of the wall signals and the sparse penalty is employed to represent the image of the indoor targets. We introduce an iterative algorithm based on the forward-backward proximal gradient technique to solve the large-scale optimization problem, which simultaneously removes unwanted wall clutter and reconstruct an image of indoor targets. Simulated and real radar data are used to validate the effectiveness of the proposed rank-deficient and sparse regularized optimization approach.
Yumurta Tavuğu Rasyonlarına Vitamin E ve Organik İlavelerinin Serumda Bazı Hormonlar Üzerine Etkisi
Authors: Kurt Şeyda , UTLU Necati
Published: February 2020

Çalışmada, yumurta tavuğu rasyonlarına vitamin E ve organik selenyumun tek başına ve kombine olarak ilavesinin serumdaki bazı hormonlar; Triiyodotironin (T3), Tiroksin (T4), Tiroit Uyarıcı Hormon (TSH), Folikül Uyarıcı Hormon (FSH) ve Luteinleştirici Hormon (LH) düzeyleri üzerine etkileri araştırılmıştır. Çalışmada, 24 haftalık yaşta 96 adet beyaz Lohman yumurta tavuğu, her biri altı alt gruptan olmak üzere eşit sayıda 4 gruba ayrıldı. Gruplar sırasıyla bazal yem (Kontrol), bazal yem + 250 mg/kg Vit-E (D-I), bazal yem + 0.9 mg/ kg organik selenyum (D-II) ve bazal yem + 250 mg/kg Vit-E+ 0.9 mg/ kg organik selenyum (D-III) içeren rasyonlarla 12 hafta beslendi. Yem ve su ad-libitum olarak sağlanmıştır. Araştırma sonunda, her gruptan alınan kan numunelerinin serumları ayrılarak, T3, T4, TSH, FSH ve LH düzeylerinin analizleri Radio Immuno Assay (RIA) ile yapılmıştır. Serum T3, T4, TSH ve FSH düzeyleri kontrol grubuna göre önemli derecede artarken (p<0.05), LH düzeylerinin ise etkilenmediği bulunmuştur. Sonuç olarak, yumurta tavuğu rasyonlarına organik Se ve Vit-E’ nin tek başına ve kombine olarak ilavesinin incelenen parametreler üzerine benzer şekilde etki ettiği sonucuna varılmıştır.
Investigation of the Effect of Cr3C2 Coating by Plasma Spray Process on Exhaust Pipe of a Diesel Engine
Authors: ŞAP Serhat , HAZAR Hanbey , ŞAP Emine
Published: February 2020

Lifetime of exhaust system decreases rapidly under negative factors such as high exhaust gas temperature, chemical solvents in exhaust gas, water vapor, water in rainy weather, mud, salt poured on the roads to prevent frosting in winter months, etc. Exhaust system of internal combustion engines need to be replaced after a while based on regions and conditions in which they are used. In this study, outer parts of exhaust pipe of a diesel engine were coated with 100-micron-thick chromium carbide (Cr3C2) material by using plasma spray method. The effect of chemical and physical solvent and deforming factors that affect externally was examined by coating exhaust pipe with chromium carbide (Cr3C2) material. As a result of experiments, it was determined that corrosion resistance increased by 85%. According to scanning electron microscope (SEM), micro hardness, EDAX, and X-RD analyses, the coating was observed to generate a uniform structure on substrate material. Thus, it could be concluded that factors decreasing the lifetime of exhaust system were met by coating material, the surface structure enhanced, and material lifetime increased compared to standard exhaust pipe.
Sözel Soruların Matematik Diline Dönüştürülmesi Becerisinde İki Öğrenci Grubunun Karşılaştırılması
Authors: ATASOY Dinçer
Published: February 2020

Bu çalışmada; Öğrencilerin sözel olarak verilen bir matematik problemini matematik diline dönüştürürken ne tür yöntemleri kullandığını ve bu yöntemleri doğru kullanıp kullanmadığı araştırılmıştır. Bu araştırmada ortaokul 6.sınıfta okuyan iki ayrı öğrenci grubunun karşılaştırılması yapılmıştır. Bu öğrenci grubu seçilirken Iğdır ilindeki ortaokullardan iki tanesi seçilmiştir. Bu okullardan biri merkezde ve genelde kamu görevlisi orta-yüksek sosyo-ekonomik duruma sahip ebeveynlerin öğrencilerinden oluşmakta, diğeri ise biraz daha merkeze uzak olan ve genelde esnaf ve dar gelirli sosyo-ekonomik duruma sahip ebeveynlerin öğrencilerinden oluşmaktadır. Lee ve Chang (2012); Van Ameron, (2003); Akkan ve ark. (2012) tarafından kullanılan ve Bal ve Karacaoğlu (2017) tarafından geliştirilen veri toplama aracı olarak Öğrencilerin Cebirsel Sözel Problemleri Çözme Stratejilerini ve Hatalarını Belirleme Formu kullanılmıştır. Her iki okuldan da 30’ar öğrenciye 5 adet açık uçlu soru sorulmuş öğrencilerin verdikleri cevaplar SPSS paket programı vasıtasıyla Aritmetiksel Akıl Yürütme, Cebir Öncesi Akıl Yürütme ve Cebirsel Akıl Yürütme başlıklarında incelenmiştir. Araştırmanın sonucunda ortaokul altıncı sınıf öğrencilerinin cebirsel sözel problemler için sonucun doğruluğuna ve çözüm yoluna karar verme, çözüme ilişkin mantıklı tartışmalar yapma, sözel problemi çözme, genelleme yapma ile uygun muhakemeyi belirleme ve kullanma boyutlarındaki beceri düzeylerinin arzu edilen seviyede olmadığı belirlenmiştir. Ebeveynlerin öğrenim düzeyinin yüksek olması ve sosyo-ekonomik durumunun iyi olması, akademik olarak öğrencinin başarısına katkı sağladığı görülmüştür.
A Study on The Usability of Some Phthalonitrile and Diiminoisoindoline Substituted Calixarenes as Liquid-Phase Extraction Agents for Some Toxic Ions
Authors: GÜNGÖR Ömer
Published: February 2020

The liquid-phase extraction performance of phthalonitrile (3 and 4) and isoindoline (5 and 6) substituted calix[4]aren derivatives was studied towards (i) some selected divalent heavy metal cations (i.e Co2+, Ni2+, Cu2+, Cd2+, Hg2+, and Pb2+), (ii) dichromate (Cr2O72-/HCr2O7-), and (iii) arsenate (H2AsO4−/HAsO42−). In general, extraction yield was observed to be higher in the case of compounds 3 and 5 (cone conformation) when compared to 4 and 6 (1,3-alternate conformation). This indicated a somehow positive effect of cone conformation on the extraction performance rather than 1,3-alternate conformation. The stoichiometric ratio between the compound 3 and 4 with mercury picrate was estimated through job’s plot analysis method.
Hava Soğutmalı PVT Panellerde Panel Yüzey Sıcaklığını Etkileyen Kontrol Parametrelerinin Optimizasyonu
Authors: ÖZAKIN Ahmet Numan , KAYA Ferhat
Published: February 2020

Panel yüzey sıcaklığı PV panelin performans parametreleri üzerinde çok önemli etkiye sahiptir. Özellikle yaz aylarında görülen panel yüzey sıcaklığındaki aşırı yükselme panel veriminde ciddi düşüşlere neden olur. Bu olumsuz durum panel yüzeyi soğutularak minimize edilebilir. Bu çalışmada, hava soğutmalı PVT sistemine kanatçıklar eklendi. Kontrol parametrelerinin (panelin arka yüzey sıcaklığı, fan hızı, kanal derinliği, kanatçık konfigürasyonu, kanatçık malzemesi) panel yüzey sıcaklığına, kanatçık sıcaklığına ve çıkış sıcaklığına etkisi Taguchi Yöntemi kullanılarak incelendi ve en uygun tasarım kombinasyonu belirlendi. Ayrıca ANSYS FLUENT analizi ile elde edilen görüntüler analiz edildi. Çalışmamızda monokristal panel kullanıldı. Bakır, alüminyum ve pirinç malzemelerden yapılmış kanatçıkların sık ve seyrek konfigürasyonları için deneyler yapıldı. Panel yüzey sıcaklığı, kanatçık sıcaklığı ve çıkış sıcaklığı için en etkili parametrelerin kanatçık konfigürasyonu, fan hızı ve kanal derinliği olduğu görüldü. Optimal tasarım kombinasyonu, panel yüzey sıcaklığı için A2-B3-C2-D3-E2 olduğu, kanatçık sıcaklığı için A1-B1-C3-D2-E2 olduğu, çıkış sıcaklığı için A1-B1-C3-D2-E3 olduğu bulundu.
Administration of Pharmaceutical Agents Prior to Testicular Sperm Extraction Procedures: A Meaningful or Meaningless Approach?
Authors: Çayan Selahittin , Yaman Onder
Published: February 2020

Background:

To date, no randomized and controlled study has demonstrated the effect of adjuvant
medical therapy on testicular sperm production before the sperm retrieval procedures in men with non-obstructive
azoospermia (NOA).

Objectives:

To present the available data on the administration of pharmaceutical agents prior to testicular sperm
extraction (TESE) procedures in order to obtain better sperm retrieval results in men with NOA.

Methods and Results:

Various pharmaceutical agents were used empirically to induce spermatogenesis in the
treatment of NOA. The rationale for adjuvant hormonal treatment has been to increase intratesticular testosterone
levels with different dosages of gonadotropins, anti-estrogen agents, or aromatase inhibitors.

Conclusion:

Based on the published studies, in the presence of a normal range of peripheral serum total testosterone
levels, no medical treatment is advised, and TESE procedures should be performed directly in men with
NOA. Further well-designed and randomized, placebo-controlled trials are needed to support the potential benefit
of pretreatment prior to TESE procedures.
Functionalised Dendrimers: Potential Tool for Antiretroviral Therapy
Authors: Kharwade Rohini , More Sachin , Mahajan Nilesh , Agrawal Pratibha
Published: February 2020

HAART (Highly Active Antiretroviral Therapy) revolutionized HIV (Human Immunodeficiency
Virus) treatment upon its introduction in 1996. But, HAART has not been a complete solution
for HIV infection. HIV remains viable in latent viral reservoirs even when the adequate concentration
of a drug is available in the blood. Hence, nanotechnology-based delivery systems are being
developed to target the HIV virus and evaluated for their safety and efficacy. Among employed
nanocarriers, dendrimers are repetitively branched molecules which are an ideal carrier for developing
preventive antiretroviral drug delivery system with low-level cytotoxicity and targeted action.
Dendrimers with potentially active multivalent sites combine with the gp120 of HIV and CD4 receptors
of the host cells and inhibit the attachment of HIV to host cells. Some of the dendrimers are capable
of interfering in HIV replication. The main objective of this review is to reveal the mechanism
of anti-retroviral action of different types of functionalized dendrimers in HIV. The significance of
dendrimers as therapeutic agents for targeting the viral reservoirs in case of HIV was discussed.
From the published literature reviewed, it can be concluded that the functionalized dendrimers are
useful as anti-HIV agents and highlighting that advance studies are required for the development of
more effective dendrimers based therapy which noticeably increases the anti-HIV activity.
Couple Therapy Based on Mindfulness to Improve the Satisfaction of Life and Pain Self-Efficacy in Patients with Chronic Pain.
Authors: Firoozi Manijeh , Rouhi Shima
Published: February 2020

Background:

To manage chronic pain, in addition to medical interventions, several psychological treatments have been designed. In couple therapy based on mindfulness, in addition to the patients, their spouses, who care for the patients, were involved. The purpose of this research was to study the effectiveness of couple therapy based on mindfulness to improve life satisfaction and pain self-efficacy in patients with chronic pain.

Methods:

The present study is a quasi-experimental and clinical trial with a control group with pre-test and post-test. The research was performed at LABAFI NEJAD Hospital in Tehran on 30 patients with chronic pain and their spouses. To measure the efficacy of treatment, a short form of self-reported Pain Self-Efficacy Questionnaire (PSEQ) and the questionnaire of life satisfaction (SWLS) were utilized.

Results:

The results showed that the level of pain self-efficacy after the intervention in the experimental group increased, while in the control group, this value remained unchanged. Also, the intervention has improved the satisfaction of life among patients in the experimental group.

Conclusion:

Couple therapy based on mindfulness, an eclectic intervention, can increase social support, improve the quality of sex, and decentralize pain. Additionally, paying attention to neglected caregivers, and patients with chronic pain can rise pain self-efficacy, and life satisfaction. Finally, suggestions for future research are offered.
Cloud-integrated Wireless-optical Broadband Access Network with Survivability
Authors: Solanki Sangita , Upadhyay Raksha , Bhatt Uma Rathore
Published: February 2020

Background:

Cloud-Integrated Wireless Optical Broadband (CIW) access networks
inheriting advantages of cloud computing, wireless and optical access networks have a broad
prospect in the future.

Objectives:

Due to failure of components like OLT level, ONU level, link or path failure and
cloud component level in CIW, survivability is becoming one of the important issues.

Methods:

In this paper, we have presented cloud-integrated wireless-optical broadband access
network with survivability using Integer Linear Programming (ILP) model, to minimize the
number of cloud components while providing maximum backup paths. Hence, we have proposed
protection through cloud-integrated wireless router to available ONUs (PCIWRAO).

Results:

So, evaluated the backup path computation. We have considered ONU level failure in
which the affected traffic is transferred through wireless routers and cloud component to the
available ONUs using Manhattan distance algorithm.

Conclusion:

Simulation results show different configurations for different number of routers and
cloud components illustrating available backup path when ONU fails.
Integrating Employee Value Model with Churn Prediction
Authors: Anh Nguyen Thi Ngoc , Tu Nguyen Danh , Solanki Vijender Kumar , Giang Nguyen Linh , Thu Vu Hoai , Son Luong Ngoc , Loc Nguyen Duc , Nam Vu Thanh
Published: February 2020

Background:

In recent years, human resource management is a crucial role in every companies
or organization’s operation. Loyalty employee or Churn employee influence the operation of
the organization. The impact of Churn employees is difference because of their role in organization.

Objective:

Thus, we define two Employee Value Models (EVMs) of organizations or companies
based on employee features that are popular of almost companies.

Methods:

Meanwhile, with the development of Artificial intelligent, machine learning is possible to
give predict data-based models having high accuracy.Thus, integrating Churn prediction, EVM and
machine learning such as support vector machine, logistic regression, random forest is proposed in
this paper. The strong points of each model are used and weak points are reduced to help the companies
or organizations avoid high value employee leaving in the future. The process of prediction integrating
Churn, value of employee and machine learning are described detail in 6 steps. The pros of
integrating model gives the more necessary results for company than Churn prediction model but the
cons is complexity of model and algorithms and speed of computing.

Results:

A case study of an organization with 1470 employee positions is carried out to demonstrate the
whole integrating churn predict, EVM and machine learning process. The accuracy of the integrating model
is high from 82% to 85%. Moreover, the some results of Churn and value employee are analyzed.

Conclusion:

This paper is proposing upgrade models for predicting an employee who may leave an organization
and integration of two models including employee value model and Churn prediction is feasible.
Optimization of Supercritical Fluid Extraction for Mariposa Christia Vespertilionis Leaves Towards Yield by Using Response Surface Methodology
Authors: Mohd Ariff Mohd Azahar , Nazri Nurul Nadiah Mohd , Abdul Razak Noor Aina , Osman Mohamed Syazwan , Jaapar Jefri
Published: February 2020

Background:

Mariposa Christia Vespertilionis (L.) (MCV) Bakh. f. is a plant,
commonly known as Mariposa or ‘butterfly wing’ due to the shape and color of its leaves
which is similar to a butterfly. MCV has been known to be used as a treatment for many diseases
such as tuberculosis, bronchitis, inflamed tonsils, colds, muscle weakness and poor
blood circulation.

Methods:

Supercritical Fluid Extraction (SFE) is the latest equipment that can be used for
the extraction of MCV leaves. SFE is the process of separating one component from another
by using supercritical fluids as the extraction media. SFE is widely used in extraction due to
its environmental friendly process compared to conventional extraction technique.

Objective:

The aim of this study was to obtain the most optimum conditions in terms of
temperature, pressure and particle size in achieving the highest amount of yield in the MCV
plant extract. Thus the manipulated parameters for this study were Temperature (T), Pressure
(P) and Particle Size (S) where the ranges used were: temperature, T (°C): 30, 40, 50,
60, 70, pressure, P (bar): 150, 200, 250, 300, 350, and particle Size, S: 63 µm, 125 µm, 250
µm, 500 µm and 1 mm.

Results:

To obtain the optimum condition of yield, Response Surface Methodology (RSM)
was used. For the RSM design of experiment, 20 samples were run throughout this experiment.

Conclusion:

The optimum parameter values generated from the RSM were 39°C for temperature,
202 bars for the pressure and 500 μm for the particle size with the yield of 7.9 %.
Actual validation runs were carried out and the percentage error was 14 %.
Regulation of Medical Devices and their Clinical Trials Studies in the USA: An Update
Authors: Manita  , Deep Aakash , Vikram  , Rana A.C. , Yadav Monu , Marwaha Rakesh K.
Published: February 2020

Background:

Need for Medical devices is very important in the healthcare sector
and related processes for global regulation. Medical devices are the apparatus or instruments
which are specifically used for diagnostics and therapeutic applications. In the USA, a regulatory
body known as FDA (Food and Drug Administration) has its unit called CDRH which
looks the manufacture, packaging and use of medical devices in the USA.

Objective:

In USA, Medical devices are classified into 3 classes: class I which look for the
medical devices used for the general control as dental floss and bandages, etc., class II which
regulate the medical devices used for the general control as well as special control as powered
wheelchairs and pregnancy kits. Class III medical devices look the general control.
PMA (Premarket Approval) and Premarket Notification application has been filed to FDA
for seeking the market authorization of medical devices. We perform clinical trials for medical
device which are quite different from the clinical trials performed for drug analysis. These
trials are performed on various age groups such as on paediatrics, adult and old age group
commonly called phase 1,2,3,4. Regulatory approval of high-risk medical device is based on
clinical studies submitted with pre-market approval. The main objective of this article is to
make the researcher aware of the regulation and clinical trials of medical devices in the USA.

Conclusion:

Every medical device should comply with FDA, QMS and QSR for marketing
in the USA. The present article has focused on the regulation of medical devices, clinical trial
phases and clinical studies on medical devices.
Correlation Coefficients of Linguistic Neutrosophic Sets and their Multicriteria Group Decision Making Strategy for Medical Treatment Options
Authors: Zhao Mei-Ling , Ye Jun
Published: February 2020

Background:

Owing to Linguistic Neutrosophic Numbers (LNNs) depicted independently
by the truth, indeterminacy, and falsity linguistic variables, they fit in with human thinking and
expressing habits to judgments of complicated objects, such as medical diagnosis and Medical
Treatment Options (MTOs) for patients in clinical medicine. Unfortunately, existing linguistic neutrosophic
Decision Making (DM) approaches have not been applied in medical DM problems so far.

Objective:

Then, the LNN multicriteria group DM method especially suits medical DM problems
with LNN information since medical DM problems commonly imply inconsistent, incomplete, and
indeterminate linguistic information due to the medical DM complexity.

Method:

Therefore, this study proposes two correlation coefficients of linguistic neutrosophic sets
(LNSs) and their multicriteria group DM method to deal with the DM problem of MTOs as a new
complementary in linguistic medical DM problems. Then, an actual example regarding the DM
problem of MTOs is provided to illustrate the applicability of the developed group DM method.

Result:

By comparative analysis with existing relative methods in LNN setting, the best MTO for
the patient with verruca plantaris is feasible.

Conclusion:

The developed DM method is effective in the DM problem of MTOs with LNN information
and provides a new way for linguistic medical DM problems.
An Efficient Multi-Core Resource Allocation using the Multi-Level Objective Functions in Cloud Environment
Authors: Krishna Siva Rama , Hussain Mohammed Ali
Published: February 2020

Background:

In recent years, the computational memory and energy conservation have
become a major problem in cloud computing environment due to the increase in data size and
computing resources. Since, most of the different cloud providers offer different cloud services and
resources use limited number of user’s applications.

Objective:

The main objective of this work is to design and implement a cloud resource allocation
and resources scheduling model in the cloud environment.

Methods:

In the proposed model, a novel cloud server to resource management technique is proposed
on real-time cloud environment to minimize the cost and time. In this model different types
of cloud resources and its services are scheduled using multi-level objective constraint programming.
Proposed cloud server-based resource allocation model is based on optimization functions to
minimize the resource allocation time and cost.

Results:

Experimental results proved that the proposed model has high computational resource allocation
time and cost compared to the existing resource allocation models.

Conclusion:

This cloud service and resource optimization model is efficiently implemented and
tested in real-time cloud instances with different types of services and resource sets.
Patients and Medical Staff Attitudes Toward the Future Inclusion of eHealth in Tuberculosis Management: Perspectives From Six Countries Evaluated using a Qualitative Framework (Preprint)
Authors: Margineanu Ioana , Louka Christina , Vincenti-Gonzalez Maria , Saktiawati Antonia Morita Iswari , Schierle Johannes , Abass Kabiru Mohammed , Akkerman Onno , Alffenaar Jan-Willem , Ranchor Adelita V , Stienstra Ymkje
Published: February 2020

BACKGROUND

Digitally delivering healthcare services is very attractive for tuberculosis (TB) management as this disease has a complex diagnosis and lengthy management and involves multiple medical and nonmedical specialists. Especially in low- and middle-income countries, eHealth could potentially offer cost-effective solutions to bridge financial, social, time, and distance challenges.

OBJECTIVE

The goal of the research is to understand what would make eHealth globally applicable and gain insight into different TB situations, opportunities, and challenges.

METHODS

We performed focus group interviews with TB experts and patients from 6 different countries on 4 different continents. The focus group interviews followed the theory of planned behavior framework to offer structured recommendations for a versatile eHealth solution. The focus group interviews were preceded by a general demographic and technology use questionnaire. Questionnaire results were analyzed using basic statistics in Excel (Microsoft Corporation). Focus group interview data were analyzed using ATLAS.ti 8 (ATLAS.ti Scientific Software Development GmbH) by assigning codes to quotations and grouping codes into the 5 domains within the framework.

RESULTS

A total of 29 patients and 32 medical staff members were included in our study. All medical staff had used the internet, whereas 31% (9/61) of patients had never been online. The codes with the most quotations were information in relation to eHealth (144 quotations) and communication (67 quotations). The consensus among all participants from all countries is that there are important communication and information gaps that could be bridged by an eHealth app. Participants from different countries also highlighted different challenges, such as a majority of asylum-seeker patients or lack of infrastructure that could be addressed with an eHealth app.

CONCLUSIONS

Within the 6 countries interviewed, there is high enthusiasm toward eHealth in TB. A potential app could first target information and communication gaps in TB, with additional modules aimed at setting-specific challenges.
Survei Asupan Asam Folat dan Seng pada Ibu Hamil di Jawa Barat
Authors: Rahayu Sri , Gumilang Lani , Astuti Sri , Nirmala Sefita Aryuti , Judistiani R. Tina Dewi
Published: February 2020

Background: The lack of folic acid and zinc intake has considerable impact on both mother and fetus, and based on this research, the intake of folic acid and zinc among pregnant women in West Java is still quite low.Objective: The purpose of this research was to know the intake and average of folic acid and zinc among pregnant women in West Java.Methods: The method of this research was descriptive using cross sectional research design, and the sample was selected by using total sampling method from research of Academic Leadership Grant (ALG) on all first trimester pregnant women as many as 176 respondents who lived in the city of Sukabumi, Cirebon, Bandung and Cimahi recruited in the period of July 2016 - February 2017. Data source was the secondary data from food diary. The analysis used univariate data.Results: Most of the respondents with the folic acid intake not fulfilled were 97,2% and most of them with the zinc intake not fulfilled were 96%, with the average of folic acid intake 163 μg/day and the average of zinc intake 5,1 mg/day.Conclusion: Most of the respondents are categorized in the not fulfilled folic acid and zinc intake with the average under the Recommended Dietary Allowances (RDA) for pregnant women.
Pola Asuh Positive Deviance dan Kejadian Stunting Balita di Kota Palembang
Authors: Bella Febriani Dwi
Published: February 2020

Latar Belakang: Stunting menjadi permasalahan utama gizi yang harus diselesaikan mengingat ini adalah ancaman bagi masa depan anak-anak Indonesia. Stunting dapat terjadi pada anak manapun yang tidak secara mutlak dipengaruhi oleh kemampuan ekonomi keluarga. Pada keluarga miskin masih dapat dijumpai anak dengan status gizi baik yang ditandai dengan tinggi badan yang normal. Dengan keadaan tersebut pola asuh keluarga positive deviance berperan besar terhadap status gizi anak. Pola asuh sebagai inti pendekatan positive deviance yaitu kebiasaan pemberian makan, kebiasaan pengasuhan, kebiasaan kebersihan dan kebiasaan mendapatkan pelayanan kesehatan.Tujuan: Penelitian ini bertujuan untuk melihat gambaran pola asuh positive deviance dan kejadian stunting balita dari keluarga miskin di Kota Palembang.Metode: Penelitian ini merupakan penelitian observasional dengan menggunakan pendekatan kualitatif dengan desain studi cross sectional. Penelitian ini dilakukan pada ibu balita dari keluarga miskin di Kota Palembang, dengan informan sebanyak 5 (lima) orang ibu dari balita stunting dan 5 (lima) orang ibu dari balita normal (tidak stunting).Hasil: Balita dengan tinggi badan normal (tidak stunting) dari keluarga miskin mendapatkan pola asuh positive deviance yaitu kebiasaan pemberian makan, kebiasaan pengasuhan, kebiasaan kebersihan dan kebiasaan mendapatkan pelayanan kesehatan yang baik. Sedangkan balita stunting dari keluarga miskin mendapatkan pola asuh yang tidak baik.Kesimpulan: Ibu dari balita dengan tinggi badan normal memiliki pola asuh positive deviance berupa kebiasaan pemberian makan, kebiasaan pengasuhan, kebiasaan kebersihan dan kebiasaan mendapatkan pelayanan kesehatan yang baik terhadap balitanya dibandingkan dengan ibu dari balita stunting dengan latar belakang perekonomian yang sama.
Hubungan Status Gizi dengan Perkembangan Anak Umur 24-60 Bulan di Kelurahan Bener Kota Yogyakarta
Authors: Kusuma Reni Merta
Published: February 2020

Background: Toddler growth and development monitoring is required. The growth is increasing the size of the cells, cell count, and intracellular tissue. Physical changes associated with growth and body structure. The progression is the increase of the function of the structure and function of the body. Growth and development of coupled, so it is important to monitor. The importance of monitoring the growing swell toddlers, researchers want to find out the correlation of these two variables.Objective: To find out the relationship between nutritional status and development of infants in Bener Village, Yogyakarta CityMethods: The draft cross-sectional study with data capture at any given moment. The population of a number of 84 children aged 24-60 months. The sampling techniques used total sampling so that the sample amounted to 84. The data obtained will be analyzed by testing the continent Koefisiensi test with Pearson Correlation Lamda.Results: The research results showed that the nutritional status of children aged 24-60 months in Kelurahan Bener 81% 3.6% normal and stated stated skinny as hell. Development of a toddler aged 24-60 months in Kelurahan Bener 89.3% 2.4% expressed and revealed irregularities. Bivariat analysis results declared between nutritional status with the development of a toddler aged 24-60 months value p of 0.493. Position korelasinya is very weak with the value of the correlation of Pearson of 0.076.Conclusion: Conclusion there is no relationship of nutritional status with the development of a toddler aged 24-60 months and correlation of both positions is very weak.
Pengembangan Pelaporan Standar Pelayanan Minimal Gawat Darurat Berbasis Web
Authors: Ningsih Kori Puspita
Published: February 2020

Latar Belakang: Rumah sakit sebagai  Badan Layanan Umum Daerah (BLUD) memiliki kewajiban  membuat dan memenuhi Standar Pelayanan Minimal (SPM). Permasalahan yang terjadi dalam sistem informasi pelaporan SPM GD diantaranya Pimpinan Tingkat Atas kesulitan mengakses dan mencari data, waktu lama utuk penyajian informasi, ketidaklengkapan informasi, kebutuhan data laporan SPM RS yang cukup heterogen dan rentan terjadinya kehilangan data dan informasi.Tujuan: mengembangkan pelaporan SPM GD berbasis WebMetode: Penelitian ini menggunakan action research, dengan pendekatan pengumpulan data kualitatif. Analisis data menggunakan analisis isi.Hasil: Hasil identifikasi kebutuhan menunjukkan RSUD Tipe B wilayah DIY membutuhkan sistem informasi pelaporan SPM GD berbasis web untuk membantu meningkatkan efisiensi dan efektifitas  proses pelaporan yang cepat, tepat dan akurat. Hasil studi kelayakan menunjukkan pengguna sudah terbiasa menggunakan komputer, tersedia software, hardware untuk mendukung pengembangan sistem informasi berbasis web. Hasil perhitungan Return Of Invesment sebesar 98,3% > 0, maka feasible dengan keuntungan 98,3% dari invenstasi. Pengembangan sistem informasi menggunakan metodelogi prototype.Hasil uji prototype dengan metode Blackbock menunjukkan fungsi/reaksi sesuai yang dilakukan aktor, sistem bekerja dengan baik dan mampu memenuhi kebutuhan pengguna.Kesimpulan: Pengembangan pelaporan SPM GD berbasis web menggunakan tahapan metodelogi prototype telah diujikan di RSUD Tipe B wilayah DIY dan menunjukkan sistem mampu memenuhi kebutuhan pengguna.
Feasibility Check of Electrification in Metrobus Line
Authors: Gucukoglu Turgay , Sarı Haluk , Erhan Koray
Published: February 2020

Today, climate change is a significant effect on population growth, especially in big cities. Transport in metropolitan cities is the most important reason for climate change with the contribution of CO2 pollution that threatens human health and the environment. Electrified transport systems can, therefore, provide a suitable solution to air pollution and health problems. This study investigates the feasibility of applying electric buses to the Metrobus line in Istanbul. Initially, Metrobus line data regarding the number of vehicles, number of stops, route length is gathered from the official Istanbul transportation system to define how much energy is needed for the routes. Then, it is analyzed how to re-charge proposed batteries for the allocation of chargers on the stations where it is applicable. It is observed that the electrification of each line is not possible.