bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep distributed convolutional neural networks: Universality
Authors: Zhou Ding-Xuan
Published: March 2018

Deep learning based on structured deep neural networks has provided powerful applications in various fields. The structures imposed on the deep neural networks are crucial, which makes deep learning essentially different from classical schemes based on fully connected neural networks. One of the commonly used deep neural network structures is generated by convolutions. The produced deep learning algorithms form the family of deep convolutional neural networks. Despite of their power in some practical domains, little is known about the mathematical foundation of deep convolutional neural networks such as universality of approximation. In this paper, we propose a family of new structured deep neural networks: deep distributed convolutional neural networks. We show that these deep neural networks have the same order of computational complexity as the deep convolutional neural networks, and we prove their universality of approximation. Some ideas of our analysis are from ridge approximation, wavelets, and learning theory.
Multi-Criteria Decision Making for PLM Maturity Analysis based on an Integrated Fuzzy AHP and VIKOR Methodology
Authors: Yu Xi , Zhang Haiqing , Bouras Abdelaziz , Ouzrout Yacine , Sekhari Aicha
Published: March 2018

A wide range of product lifecycle management (PLM) maturity models are proposed to assess the relative position of companies on their road to complete PLM implementation. However, it is a tough job for the company to dynamically evaluate the gradual process of PLM maturity by using existing values and accurately make decisions of improving PLM maturity by selecting the optimum alternative. A fuzzy PLM components maturity model (PCMA) is presented to build the internal logical relationship between maturity levels and existing values that can automatically predict the unknown PLM maturity levels. A fuzzy AHP–VIKOR methodology is used to make a decision among option PLM strategies. The weights of the criteria are determined by fuzzy pairwise comparison matrices (PCM). The weights of alternatives with respect to criteria are calculated by fuzzy VIKOR. The fuzzy AHP–VIKOR is a compromise solution and has the ability of transfer subjective and implicit linguistics into objective and transparent data. A numerical example illustrates and clarifies the running steps of the proposed methodology.
Modified Krill Herd Swarm Optimization (MKHSO) Based Optimal Neural Network Model for Analysis Multi-Performance Parameters in Manufacturing System
Authors: Lakshmi R. Prasanna , Raja P. Nelson
Published: March 2018

Develop a multi-target exhibit by considering the workstation reliability for preventive maintenance perspective, the general availability of the framework for production purposes, and total operational expenses for both preventive support and production arranging decisions. Despite that, the greater parts of the reviews in upkeep optimization do not consider the creation necessities experienced eventually. In this paper, hybrid inspired optimization model for the performance analysis in the manufacturing industry is utilized. This forecast investigation neural Network considered for weight streamlining procedure alongside parameters, for example, Total Operational Cost (TOC), availability and reliability of assembling framework. Weight examination krill and swarm intelligence are used to limit Mean Square Error (MSE) for all parameters. All the perfect outcomes show the way that the refined slip-up qualities between the output of the trial values and the foreseen qualities are solidly proportionate to zero in the arranged framework. From the results, the proposed Modified Krill herd Swarm Optimization (MKHSO) based perfect neural framework exhibits a precision of 98.23%, which diverges from the existing methodology.
Secured medical image compression using DES encryption technique in Bandelet multiscale transform
Authors: Raja S. P.
Published: March 2018

An efficient and secure platform is needed for data storage and transmission, specially for the multimedia content like audio, image and video. In this paper, a new methodology is proposed for the secured medical image compression. Initially, Bandelet transform is applied to the input medical image to obtain the coefficients. Using unequal error protection (UEP) method, the obtained coefficients are prioritized. These coefficients are encrypted using data encryption standard (DES) and will be encoded using listless set partitioning embedded block (Listless SPECK) technique. For the performance evaluation, peak signal-to-noise ratio (PSNR), mean square error (MSE), structural similarity index (SSIM), image quality index (IQI), average difference (AD), normalized cross-correlation (NK), structural content (SC), maximum difference (MD), Laplacian mean squared error (LMSE) and normalized absolute error (NAE) are taken. From the experimental results and performance evaluation, it is shown that the proposed approach is producing good results.
Fermionic covariant prolongation structure theory for a (2+1)-dimensional super nonlinear evolution equation
Authors: Yan Zhaowen , Li Chuanzhong
Published: March 2018

In the framework of the fermionic covariant prolongation structure theory (PST), we investigate the integrability of a new [Formula: see text]-dimensional super nonlinear evolution equation (NEE). The prolongation structure of the super integrable system is presented. Moreover, we derive the Bäcklund transformation of the super integrable system.
Uni-Soft Commutative Ideals and Closed Uni-Soft Ideals in BCI-Algebras
Authors: Bordbar Hashem , Borzooei Rajab Ali , Jun Young Bae
Published: March 2018

The notions of uni-soft commutative ideals and closed uni-soft ideals in [Formula: see text]-algebras are introduced, and related properties are investigated. Conditions for a uni-soft ideal to be closed are provided. Relations between a uni-soft ideal and a uni-soft commutative ideal are investigated. Conditions for a uni-soft ideal to be a uni-soft commutative ideal are provided. A new uni-soft commutative ideal from an old one is constructed.
New Applications of m-Polar Fuzzy Competition Graphs
Authors: Akram Muhammad , Sarwar Musavarah
Published: March 2018

An [Formula: see text]-polar fuzzy model is a generalization of the fuzzy model. This model is useful for multi-polar information, multi-agent, multi-attribute and multi-object network models. In this research paper, we first introduce certain new concepts, including [Formula: see text]-polar fuzzy digraphs, [Formula: see text]-polar fuzzy-out neighborhood, [Formula: see text]-polar fuzzy-in neighborhood, [Formula: see text]-polar fuzzy competition graphs and [Formula: see text]-polar fuzzy [Formula: see text]-competition graphs. Moreover, we describe the construction of [Formula: see text]-polar fuzzy competition graphs of certain products of [Formula: see text]-polar fuzzy digraphs from their respective [Formula: see text]-polar fuzzy competition graphs. We present some applications of [Formula: see text]-polar fuzzy competition graphs in food webs. Finally, we present certain algorithms for computing strength of competition between species.
Modeling
n
-Symmetry Vector Fields using Higher-Order Energies
Authors: Brandt Christopher , Scandolo Leonardo , Eisemann Elmar , Hildebrandt Klaus
Published: March 2018

We introduce a variational approach for modeling
n
-symmetry vector and direction fields on surfaces that supports interpolation and alignment constraints, placing singularities and local editing, while providing real-time responses. The approach is based on novel biharmonic and
m
-harmonic energies for
n
-fields on surface meshes and the integration of hard constraints to the resulting optimization problems. Real-time computation rates are achieved by a model reduction approach employing a Fourier-like
n
-vector field decomposition, which associates frequencies and modes to
n
-vector fields on surfaces. To demonstrate the benefits of the proposed
n
-field modeling approach, we use it for controlling stroke directions in line-art drawings of surfaces and for the modeling of anisotropic BRDFs, which define the reflection behavior of surfaces.
Negative regulation of cellular Ca2+ mobilization by ryanodine receptor type 3 in mouse mesenteric artery smooth muscle
Authors: Matsuki Katsuhito , Kato Daiki , Takemoto Masashi , Suzuki Yoshiaki , Yamamura Hisao , Ohya Susumu , Takeshima Hiroshi , Imaizumi Yuji
Published: March 2018

Physiological functions of type 3 ryanodine receptors (RyR3) in smooth muscle (SM) tissues are not well understood, in spite of their wide expression. However, the short isoform of RyR3 is known to be a dominant-negative variant (DN-RyR3), which may negatively regulate functions of both RyR2 and full-length (FL) RyR3 by forming hetero-tetramers. Here, functional roles of RyR3 in the regulation of Ca2+ signaling in mesenteric artery SM cells (MASMCs) were examined using RyR3 homozygous knockout mice (RyR3−/−). Quantitative PCR analyses suggested that the predominant RyR3 subtype in MASMs from wild-type mice (RyR3+/+) was DN-RyR3. In single MASMCs freshly isolated from RyR3−/−, the EC50 of caffeine to induce Ca2+ release was lower than that in RyR3+/+ myocytes. The amplitude and frequency of Ca2+ sparks and spontaneous transient outward currents in MASMCs from RyR3−/− were all larger than those from RyR3+/+. Importantly, mRNA and functional expressions of voltage-dependent Ca2+ channel and large-conductance Ca2+-activated K+ (BK) channel in MASMCs from RyR3−/− were identical to those from RyR3+/+. However, in the presence of BK channel inhibitor, paxilline, the pressure rises induced by BayK8644 in MA vascular beds of RyR3−/− were significantly larger than in those of RyR3+/+. This indicates that the negative feedback effects of BK channel activity on intracellular Ca2+ signaling was enhanced in RyR3−/−. Thus, RyR3, and, in fact, mainly DN-RyR3, via a complex with RyR2 suppresses Ca2+ release and indirectly regulated membrane potential by reducing BK channel activity in MASMCs and presumably can affect the regulation of intrinsic vascular tone.
Effects of phase correlations in naturalistic stimuli on quantitative information coding by fly photoreceptors
Authors: Ignatova Irina I. , French Andrew S. , Frolov Roman V.
Published: March 2018

Natural visual scenes are rarely random. Instead, intensity and wavelength change slowly in time and space over many regions of the scene, so that neighboring temporal and spatial visual inputs are more correlated and contain less information than truly random signals. It has been suggested that sensory optimization to match these higher order correlations (HOC) occurs at the earliest visual stages, and that photoreceptors can process temporal natural signals more efficiently than random signals. We tested this early-stage hypothesis by comparing the information content of Calliphora vicina photoreceptor responses to naturalistic inputs before and after removing HOC by randomizing phase. Forty different, 60-s long, naturalistic sequences (NS) were used, together with randomized-phase versions of the same sequences to give pink noise (PN) so that each input pair had identical means, variances, mean contrasts, and power spectra. We measured the information content of inputs and membrane potential responses by three different methods: coherence, mutual information, and compression entropy. We also used entropy and phase statistics of each pair as measures of HOC. Responses to randomized signals generally had higher gain, signal-to-noise ratio, and information rates than responses to NS. Information rate increased with a strong, positive, linear correlation to phase randomization within sequence pairs. This was confirmed by varying the degree of phase randomization. Our data indicate that individual photoreceptors encode input information by Weber’s law, with HOC within natural sequences reducing information transfer by decreasing the number of local contrast events that exceed the noise-imposed threshold.

NEW & NOTEWORTHY Natural visual scenes feature statistical regularities, or higher order correlations (HOC), both in time and space, to encode surfaces, textures, and object boundaries. Visual systems rely on this information; however, it remains controversial whether individual photoreceptors can discriminate and enhance information encoded in HOC. Here we show that the more HOC the stimulus contains, the lower the information transfer rate of photoreceptors. We explain our findings by applying the Weber’s paradigm of differential signal perception.
Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety
Authors: Holwerda Seth W. , Luehrs Rachel E. , Gremaud Allene L. , Wooldridge Nealy A. , Stroud Amy K. , Fiedorowicz Jess G. , Abboud Francois M. , Pierce Gary L.
Published: March 2018

Relative burst amplitude of muscle sympathetic nerve activity (MSNA) is an indicator of augmented sympathetic outflow and contributes to greater vasoconstrictor responses. Evidence suggests anxiety-induced augmentation of relative MSNA burst amplitude in patients with panic disorder; thus we hypothesized that acute stress would result in augmented relative MSNA burst amplitude and vasoconstriction in individuals with chronic anxiety. Eighteen participants with chronic anxiety (ANX; 8 men, 10 women, 32 ± 2 yr) and 18 healthy control subjects with low or no anxiety (CON; 8 men, 10 women, 39 ± 3 yr) were studied. Baseline MSNA and 24-h blood pressure were similar between ANX and CON ( P > 0.05); however, nocturnal systolic blood pressure % dipping was blunted among ANX ( P = 0.02). Relative MSNA burst amplitude was significantly greater among ANX compared with CON immediately preceding (anticipation) and during physiological stress [2-min cold pressor test; ANX: 73 ± 5 vs. CON: 59 ± 3% arbitrary units (AU), P = 0.03] and mental stress (4-min mental arithmetic; ANX: 65 ± 3 vs. CON: 54 ± 3% AU, P = 0.02). Increases in MSNA burst frequency, incidence, and total activity in response to stress were not augmented among ANX compared with CON ( P > 0.05), and reduction in brachial artery conductance during cold stress was similar between ANX and CON ( P = 0.92). Relative MSNA burst amplitude during mental stress was strongly correlated with state ( P < 0.01) and trait ( P = 0.01) anxiety (State-Trait Anxiety Inventory), independent of age, sex, and body mass index. Thus in response to acute stress, both mental and physiological, individuals with chronic anxiety demonstrate selective augmentation in relative MSNA burst amplitude, indicating enhanced sympathetic drive in a population with higher risk for cardiovascular disease.

NEW & NOTEWORTHY Relative burst amplitude of muscle sympathetic nerve activity in response to acute mental and physiological stress is selectively augmented in individuals with chronic anxiety, which is a prevalent condition that is associated with the development of cardiovascular disease. Augmented sympathetic burst amplitude occurs with chronic anxiety in the absence of common comorbidities. These findings provide important insight into the relation between anxiety, acute stress and sympathetic activation.
Contribution from motor unit firing adaptations and muscle coactivation during fatigue
Authors: Contessa Paola , Letizi John , De Luca Gianluca , Kline Joshua C.
Published: March 2018

The control of motor unit firing behavior during fatigue is still debated in the literature. Most studies agree that the central nervous system increases the excitation to the motoneuron pool to compensate for decreased force contributions of individual motor units and sustain muscle force output during fatigue. However, some studies claim that motor units may decrease their firing rates despite increased excitation, contradicting the direct relationship between firing rates and excitation that governs the voluntary control of motor units. To investigate whether the control of motor units in fact changes with fatigue, we measured motor unit firing behavior during repeated contractions of the first dorsal interosseous (FDI) muscle while concurrently monitoring the activation of surrounding muscles, including the flexor carpi radialis, extensor carpi radialis, and pronator teres. Across all subjects, we observed an overall increase in FDI activation and motor unit firing rates by the end of the fatigue task. However, in some subjects we observed increases in FDI activation and motor unit firing rates only during the initial phase of the fatigue task, followed by subsequent decreases during the late phase of the fatigue task while the coactivation of surrounding muscles increased. These findings indicate that the strategy for sustaining force output may occasionally change, leading to increases in the relative activation of surrounding muscles while the excitation to the fatiguing muscle decreases. Importantly, irrespective of changes in the strategy for sustaining force output, the control properties regulating motor unit firing behavior remain unchanged during fatigue.

NEW & NOTEWORTHY This work addresses sources of debate surrounding the manner in which motor unit firing behavior is controlled during fatigue. We found that decreases in the motor unit firing rates of the fatiguing muscle may occasionally be observed when the contribution of coactive muscles increases. Despite changes in the strategy employed to sustain the force output, the underlying control properties regulating motor unit firing behavior remain unchanged during muscle fatigue.
Undifferentiated Adipose Tissue Stem Cell Transplantation Promotes Hepatic Regeneration, Ameliorates Histopathologic Damage of the Liver, and Upregulates the Expression of Liver Regeneration- and Liver-Specific Genes in a Rat Model of Partial Hepatectomy
Authors: Apostolou Konstantinos G. , Papanikolaou Ioannis G. , Katselis Charalampos , Feretis Themistoklis , Kletsas Dimitrios , Konstadoulakis Manousos M. , Lymperi Maria , Saetta Angelica A. , Tsikalakis Spiros , Agrogiannis George , Patsouris Efstratios , Zografos George C. , Papalois Apostolos E.
Published: March 2018

Objective. Adipose tissue stem cells (ADSCs) present a promising therapeutic method to alleviate liver failure (LF). The purpose of this prospective study was to evaluate the efficacy of undifferentiated ADSC transplantation on liver regeneration and on the expression of liver regeneration- and liver-specific genes, following 60% partial hepatectomy (PHx). Methods. Sixty female rats were subjected to PHx and were transplanted with 106 or 2 × 106 ADSCs, either into the portal vein (PV) or into the hepatic parenchyma. Animals of the control group were not transplanted and served as controls. Animals were sacrificed on the 4th, the 7th, or the 15th postoperative day (POD). Results. The transplanted ADSCs were successfully engrafted into the liver parenchyma and ameliorated the histopathologic damage on the 7th and 15th POD. All transplanted animals demonstrated a significantly higher liver regeneration rate on the 4th and 7th POD, compared with the control group. The expression of hepatocyte growth factor, α-fetoprotein, tyrosine aminotransferase, hepatocyte nuclear factor 4a, and cytochrome P450 1A2 was significantly upregulated, compared with the control group. Conclusions. Although undifferentiated, ADSC transplantation significantly enhanced the liver regeneration process. These findings may be proven clinically valuable, especially in cases of acute LF.
Serum Procalcitonin Levels in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion
Authors: Fujii Yosuke , Yashiro Masato , Yamada Mutsuko , Kikkawa Tomonobu , Nosaka Nobuyuki , Saito Yukie , Tsukahara Kohei , Ikeda Masanori , Morishima Tsuneo , Tsukahara Hirokazu
Published: March 2018

Procalcitonin (PCT) is used as a biomarker in severe infections. Here, we retrospectively investigated levels of serum PCT, C-reactive protein (CRP), and inflammatory cytokines (IL-6, TNF-α, and IFN-γ) in the second phase of patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). Nine AESD pediatric patients (4 men, 5 women; AESD group) admitted to Okayama University Hospital from 2010 to 2016 were compared with 10 control patients with febrile seizures (FS) (3 men, 7 women; FS group). Mean PCT concentrations (ng/mL) in the AESD and FS groups were significantly different, at 9.8 ± 6.7 and 0.8 ± 0.9, respectively (p=0.0006). CRP (mg/dL) were 0.79 ± 0.89 and 1.4 ± 1.0 (p=0.94), respectively; IL-6 (pg/mL) were 449.7 ± 705.0 and 118.3 ± 145.4 (p=0.20), respectively; TNF-α (pg/mL) were 18.6 ± 12.5 and 16.6 ± 6.0 (p=0.67), respectively; and IFN-γ (pg/mL) were 79.6 ± 158.5 and 41.9 ± 63.7 (p=0.56), respectively. Ratios of PCT to CRP were 27.5 ± 34.2 and 3.2 ± 6.8 (p<0.0001), respectively. The sensitivity and specificity in the diagnosis of AESD using a cutoff of PCT/CRP ratio of 1.0 were 79% and 100%, respectively. These results suggest that PCT and the PCT/CRP ratio are useful in auxiliary diagnosis of the second stage of AESD, and in AESD, PCT is likely to increase through a different mechanism.
B7-H1 Expression Is Required for Human Endometrial Regenerative Cells in the Prevention of Transplant Vasculopathy in Mice
Authors: Ye Kui , Lan Xu , Wang Grace , Zhang Baoren , Xu Xiaoxi , Li Xiang , Zhao Yiming , Wang Hao
Published: March 2018

Vasculopathy is one of the primary pathological changes in chronic rejection of vascularized allograft transplantation. Endometrial regenerative cells (ERCs) are mesenchymal-like stromal cells with immunosuppressive effect. B7-H1 is a negative costimulator that mediates active immune suppression. The aim of this study was to investigate the requirement of B7-H1 in the immunoregulation of ERCs in preventing transplant vasculopathy of aorta allografts. The results showed that B7-H1 expression on ERCs was upregulated by IFN-γ in a dose-dependent manner and it was required for ERCs to inhibit the proliferation of peripheral blood mononuclear cells (PBMCs) in vitro. ERCs could alleviate transplant vasculopathy, as the intimal growth of transplanted aorta was limited, and the preventive effects were correlated with an increase in the percentages of CD11c+MHC class IIlowCD86low dendritic cells, CD68+CD206+ macrophages, and CD4+CD25+Foxp3+ T cells, as well as a decrease in the percentages of CD68+ macrophages, CD3+CD4+ T cells, CD3+CD8+ T cells, and donor-reactive IgM and IgG antibodies. Moreover, overexpression of B7-H1 by IFN-γ can promote the immunosuppressive effect of ERCs. These results suggest that overexpression of B7-H1 stimulated by IFN-γ is required for ERCs to prevent the transplant vasculopathy, and this study provides a theoretical basis for the future clinical use of human ERCs.
Robust Evolution Method of Active Contour Models and Application in Segmentation of Image Sequence
Authors: Liu Guoqi , Li Haifeng
Published: March 2018

Active contour models are widely used in image segmentation. In order to obtain ideal object boundary, researchers utilize various information to define new models for image segmentation. However, the models could not meet all scenes of image. In this paper, we propose a block evolution method to improve the robustness of contour evolution. A block matrix is consisted of contours of former iterations and contours of shape prior, and a nuclear norm of the matrix is a measure of the similarity of these shapes. The constraint of the nuclear norm minimization is imposed on the evolution of active contour models, which could avoid large deformation of the adjacent curves and keep the shape conformability of contour in the evolution. The shape prior can be integrated into the block evolution method, which is effective in dealing with missing features of images and noise. The proposed method can be applied to image sequence segmentation. Experiments demonstrate that the proposed method improves the robust performance of active contour models and can increase the flexibility of applications in image sequence segmentation.
Early Changes in Tumor Perfusion from T1-Weighted Dynamic Contrast-Enhanced MRI following Neural Stem Cell-Mediated Therapy of Recurrent High-Grade Glioma Correlate with Overall Survival
Authors: Sahoo Prativa , Frankel Paul , Ressler Julie , Gutova Margarita , Annala Alexander J. , Badie Behnam , Portnow Jana , Aboody Karen S. , D’Apuzzo Massimo , Rockne Russell C.
Published: March 2018

Background. The aim of this study was to correlate T1-weighted dynamic contrast-enhanced MRI- (DCE-MRI-) derived perfusion parameters with overall survival of recurrent high-grade glioma patients who received neural stem cell- (NSC-) mediated enzyme/prodrug gene therapy. Methods. A total of 12 patients were included in this retrospective study. All patients were enrolled in a first-in-human study (NCT01172964) of NSC-mediated therapy for recurrent high-grade glioma. DCE-MRI data from all patients were collected and analyzed at three time points: MRI#1—day 1 postsurgery/treatment, MRI#2— day 7 ± 3 posttreatment, and MRI#3—one-month follow-up. Plasma volume (Vp), permeability (Ktr), and leakage (λtr) perfusion parameters were calculated by fitting a pharmacokinetic model to the DCE-MRI data. The contrast-enhancing (CE) volume was measured from the last dynamic phase acquired in the DCE sequence. Perfusion parameters and CE at each MRI time point were recorded along with their relative change between MRI#2 and MRI#3 (Δ32). Cox regression was used to analyze patient survival. Results. At MRI#1 and at MRI#3, none of the parameters showed a significant correlation with overall survival (OS). However, at MRI#2, CE and λtr were significantly associated with OS (p<0.05). The relative λtr and Vp from timepoint 2 to timepoint 3 (Δ32λtr and Δ32Vp) were each associated with a higher hazard ratio (p<0.05). All parameters were highly correlated, resulting in a multivariate model for OS including only CE at MRI#2 and Δ32Vp, with an R2 of 0.89. Conclusion. The change in perfusion parameter values from 1 week to 1 month following NSC-mediated therapy combined with contrast-enhancing volume may be a useful biomarker to predict overall survival in patients with recurrent high-grade glioma.
Seismic Retrofit of a Multispan Prestressed Concrete Girder Bridge with Friction Pendulum Devices
Authors: Avossa Alberto Maria , Di Giacinto Danilo , Malangone Pasquale , Rizzo Fabio
Published: March 2018

The paper deals with the proposal and application of a procedure for the seismic retrofit of an existing multispan prestressed concrete girder bridge defined explicitly for the use of friction pendulum devices as an isolation system placed between piers top and deck. First, the outcomes of the seismic risk assessment of the existing bridge, performed using an incremental noniterative Nonlinear Static Procedure, based on the Capacity Spectrum Method as well as the Inelastic Demand Response Spectra, are described and discussed. Then, a specific multilevel design process, based on a proper application of the hierarchy of strength considerations and the Direct Displacement‐Based Design approach, is adopted to dimension the FPD devices. Furthermore, to assess the impact of the FPD nonlinear behaviour on the bridge seismic response, a device model that reproduces the variation of the normal force and friction coefficient, the bidirectional coupling, and the large deformation effects during nonlinear dynamic analyses was used. Finally, the paper examines the effects of the FPD modelling parameters on the behaviour of the retrofitted bridge and assesses its seismic response with the results pointing out the efficiency of the adopted seismic retrofit solution.
Acute and Long-Term Hemodynamic Effects of MitraClip Implantation on a Preexisting Secondary Right Heart Failure
Authors: Hünlich M. , Lubos E. , Beuthner B. E. , Puls M. , Bleckmann A. , Beißbarth T. , Tichelbäcker T. , Rudolph V. , Baldus S. , Schäfer U. , Treede H. , Von Bardeleben R. S. , Blankenberg S. , Schillinger W.
Published: March 2018

Positive results of MitraClip in terms of improvement in clinical and left ventricular parameters have been described in detail. However, long-term effects on secondary pulmonary hypertension were not investigated in a larger patient cohort to date. 70 patients with severe mitral regurgitation, additional pulmonary hypertension, and right heart failure as a result of left heart disease were treated in the heart centers Hamburg and Göttingen. Immediately after successful MitraClip implantation, a reduction of the RVOT diameter from 3.52 cm to 3.44 cm was observed reaching a statistically significant value of 3.39 cm after 12 months. In contrast, there was a significant reduction in the velocity of the tricuspid regurgitation (TR) from 4.17 m/s to 3.11 m/s, the gradient of the TR from 48.5 mmHg to 39.3 mmHg, and the systolic pulmonary artery pressure (PAPsyst) from 58.6 mmHg to 50.0 mmHg. This decline continued in the following months (Vmax TR 3.09 m/s, peak TR 38.6 mmHg, and PAPsyst 47.4 mmHg). The tricuspid annular plane systolic excursion (TAPSE) increased from 16.5 mm to 18.9 mm after 12 months. MitraClip implantation improves pulmonary artery pressure, tricuspid regurgitation, and TAPSE after 12 months. At the same time, there is a decrease in the RVOT diameter without significant changes in other right ventricular and right atrial dimensions.
Experimental Validation of Numerical Model for Bi‐Tilt‐Isolator
Authors: Shih Ming-Hsiang , Sung Wen-Pei , Ho Chia-Yu
Published: March 2018

Bi‐Tilt Isolator (BTI) is composed of bi‐tilt beveled substrate and slider. The advantages of BTI are that the maximum upload seismic force of structure can be easily controlled and displacement of isolation layer will be reduced. Sliding force, friction force, and impulse force are caused in the slanting process of BTI, nonlinear behavior. A nonlinear mathematical model is derived based on the sliding upwards, sliding downwards, and transition stages. Then, BTI element of nonlinear analysis program, GENDYN, is developed by the fourth‐order Runge‐Kutta method, the discretized ordinary differential equation for three movement stages of BTI. Then, test set‐up of superstructure installed with BTI is tested and recorded the real displacement and acceleration responses under conditions of full lubrication, mild lubrication, and without lubrication between interface of bi‐tilt beveled substrate and slider with three various initial displacements. The comparison of simulation results and test results shows the following: (1) root mean square error is below 1.35% for WD40 sprayed, 0.47% for WD40 whipped, and 0.54% for without lubrication, respectively; (2) the maximum root mean square error for simulating with cubic polynomial function of friction is much less than those of constant friction except conditions of full lubrication, which are not affected by kinetic friction force; (3) application of cubic polynomial function for simulating friction of BTI with three different lubricated conditions can perform very fine simulation results, compared with the test results. This proposed mathematical model and BTI element of GENDYN program, using cubic polynomial function of friction, perform fine simulation capability to assess nonlinear isolation effect of structure installed with BTI.
Diagnostic Accuracy of NICE Classification System for Optical Recognition of Predictive Morphology of Colorectal Polyps
Authors: Patrun Josipa , Okreša Lucija , Iveković Hrvoje , Rustemović Nadan
Published: March 2018

The NICE classification is an international endoscopic classification of colorectal neoplasia through a narrowband spectrum that on the basis of lesion colors, vascular pattern, and structure of the surface of the mucous membrane classifies colorectal neoplasms in three categories: type 1 as hyperplastic lesions, type 2 as adenomas, and type 3 as invasive tumors. The aim of this study was to verify diagnostic accuracy of the NICE classification system compared to the reference standard: histopathological analysis. This retrospective study was conducted by ten physicians on a sequential sample of 418 patients and 735 polyps. The total diagnostic accuracy of the NICE classification system is found to be 76.7%. Optical recognition is significantly better with larger polyps, high-risk lesions (HGIEN), and neoplastic lesions. This research has shown that the NICE classification system is at the moment inferior to histopathological analysis. However, it is noticed that some physicians achieve significantly better results, with the accuracy of diagnosis ranging from 59.5% to 84.2%. These results show that with proper training of physicians and the use of endoscope enhancements to improve image quality, the NICE classification system could in the future potentially replace the histopathological diagnosis process.
Chinese National Condition Based Power Dispatching Optimization in Microgrids
Authors: Chen Gang , Wang Jian-Ming , Yuan Xiao-Dong , Chen Liang , Zhao Lu-Jia , He Yu-Ling
Published: March 2018

This paper proposed a study on the power dispatching optimization in the microgrid aiming at Chinese national condition based on PSO algorithm. The whole work is on the basis of the weighted factor variation of the objective function due to different weather conditions. Three cases including the good contamination-diffusing weather condition, the smog weather condition, and the normal condition are considered, respectively. In the case of smog weather, the new energy generation and the battery system will be all out to use as less power as possible from the primary grid so that the pollution produced by coal consumption in the thermal power plants can be upmost reduced. However, in the case of perfect contamination-diffusing weather, the battery is not used to reserve its lifetime, while a large amount of exchanged power from the primary grid is used to obtain a most economic-efficient effect. In normal condition, the power dispatching is performed in a most balanced way considering not only the cost but also the environmental management. The case study in Suzhou Industrial Part confirms the effectiveness of the proposed method in this paper.
Lung Mesenchymal Stem Cells Ameliorate Elastase-Induced Damage in an Animal Model of Emphysema
Authors: Cappetta Donato , De Angelis Antonella , Spaziano Giuseppe , Tartaglione Gioia , Piegari Elena , Esposito Grazia , Ciuffreda Loreta Pia , Liparulo Angela , Sgambato Manuela , Russo Teresa Palmira , Rossi Francesco , Berrino Liberato , Urbanek Konrad , D’Agostino Bruno
Published: March 2018

Pulmonary emphysema is a respiratory condition characterized by alveolar destruction that leads to airflow limitation and reduced lung function. Although with extensive research, the pathophysiology of emphysema is poorly understood and effective treatments are still missing. Evidence suggests that mesenchymal stem cells (MSCs) possess the ability to engraft the injured tissues and induce repair via a paracrine effect. Thus, the aim of this study was to test the effects of the intratracheal administration of lung-derived mouse MSCs in a model of elastase-induced emphysema. Pulmonary function (static lung compliance) showed an increased stiffness induced by elastase, while morphometric findings (mean linear intercept and tissue/alveolar area) confirmed the severity of alveolar disruption. Contrarily, MSC administration partially restored lung elasticity and alveolar architecture. In the absence of evidence that MSCs acquired epithelial phenotype, we detected an increased proliferative activity of aquaporin 5- and surfactant protein C-positive lung cells, suggesting MSC-driven paracrine mechanisms. The data indicate the mediation of hepatocyte growth factor in amplifying MSC-driven tissue response after injury. Our study shed light on supportive properties of lung-derived MSCs, although the full identification of mechanisms orchestrated by MSCs and responsible for epithelial repair after injury is a critical aspect yet to be achieved.
Cortical Blindness and Altered Mental Status following Routine Hemodialysis, a Case of Iatrogenic Cerebral Air Embolism
Authors: Lau Lawrence , London Kory
Published: March 2018

Cerebral air embolism is a known complication from a myriad of iatrogenic causes. This case describes a 60-year-old female presenting from hemodialysis with altered mental status, bilateral homonymous hemianopia, and repetitive speech. A noncontrast head CT revealed air in the vein of Galen and the deep cerebral veins of the left thalamus and occipital sulcus, a complication from air being introduced into the patient via improper flushing of dialysis tubing. The retrograde flow of air bubbles in the upright patient during dialysis was likely responsible for the air embolus lodging in the cerebral vasculature. This patient was transferred to receive hyperbaric therapy, whereupon the patient survived with residual attention and spatial deficits.
Treatment Outcomes of Endoscopic Submucosal Dissection for Adenocarcinoma Originating from Long-Segment Barrett’s Esophagus versus Short-Segment Barrett’s Esophagus
Authors: Shimizu Tomoki , Fujisaki Junko , Omae Masami , Yamasaki Akira , Horiuchi Yusuke , Ishiyama Akiyoshi , Yoshio Toshiyuki , Hirasawa Toshiaki , Yamamoto Yorimasa , Tsuchida Tomohiro
Published: March 2018

Background: In recent years, effective outcomes of endoscopic submucosal dissection (ESD) for esophagogastric junction cancer including short-segment Barrett’s esophagus (SSBE) cancer have been reported. However, the efficacy of ESD for long-segment Barrett’s esophagus (LSBE) cancer is unknown. Aim: To clarify the treatment outcomes of ESD for LSBE cancer versus SSBE cancer. Methods: A total of 86 patients with 91 superficial Barrett’s esophageal adenocarcinomas who underwent ESD were enrolled; of these, 68 had underlying SSBE and 18 had LSBE. Procedure outcomes and prognosis were compared. Results: There was no significant difference in age and tumor diameter among patients. The only complication observed was stricture, but it was not significant (2 vs. 9%). No significant difference was observed in the negative horizontal margin rates (94.1 vs. 95.7%), R0 resection rates (83.8 vs. 82.6%), curative resection rates (72.1 vs. 73.9%), and noncurative factors. Both LSBE and SSBE cancer showed favorable 3-year overall survival rates (95.0 vs. 94.4%) in the median observation period of 28.5 months. Conclusions: ESD for LSBE cancer achieved procedure outcomes and short-term prognosis comparable to SSBE. ESD has the potential to be an effective therapeutic option for esophageal neoplasms in patients with LSBE.
Support of New Triage Protocol among Acute Stroke Care Providers
Authors: Hussein Haitham M. , Anderson David C.
Published: March 2018

Objective: We conducted an online survey to gauge the acceptance of sending acute stroke patients with suspected large vessel occlusion (LVO) directly to an endovascular-capable hospital (ECH) even if that means bypassing a closer alteplase-capable hospital (ACH) without endovascular capability. Methods: The survey was composed of two cases of acute stroke, one with cortical symptoms suggestive of LVO and the other without. In each case, responders were asked to choose between triaging to a closer ACH or an ECH that is further away and to provide an opinion regarding the maximum extra travel time they would tolerate if they chose the ECH. The survey was sent electronically to national groups of neurologists, emergency department (ED) physicians, emergency medical service (EMS) directors, and stroke coordinators. Results: There were 320 responders from 44 states, most of them with 10 years or more of experience. Most of the responders, 72.5%, chose ECH for the LVO case, while 56% chose ACH for the non-LVO case. There were marked differences in responses by specialty: neurology strongly supported ECH for LVO and strongly supported ACH for non-LVO, most ED and EMS chose ECH for both cases, and stroke coordinators were the least supportive of bypassing ACH. Almost all groups agreed on 30 min as the acceptable extra transfer time to ECH. Conclusion: Among the survey responders, there is a broad acceptance of the idea of bypassing ACH and going straight to ECH when LVO is suspected; however, there is less agreement on triaging patients with non-LVO stroke.
Improved Production of Highly Active and Pure Human Creatine Kinase MB
Authors: Selimoglu Sureyya Mert , Kasap Murat , Akpinar Gurler , Karadenizli Aynur , Wis Abdul Mounem , Gormus Uzay
Published: March 2018

Human creatine kinase MB (hCKMB) is one of the most preferred biomarkers used for the diagnosis of acute coronary syndrome due to its high sensitivity and specificity. The increasing need for highly purified and biologically active hCKMB in the field of diagnostics makes its production valuable. Currently, the production of hCKMB is mainly achieved in methylotrophic yeast, Pichia pastoris, because the production in Escherichia coli is challenging and generally yields an inactive enzyme with a low quantity. With the aim of finding the best way for the high-yield production of active hCKMB in E. coli, an efficient strategy was developed using a construct allowing tandem expression of each subunit with 2 different tags. The strategy allowed the efficient expression and separate characterization of each subunit and 1-step purification of the heterodimeric protein into homogeneity. The heterodimeric protein displayed more than 11-fold greater specific activity than the commercially available one. The production strategy described in this study shows a clear advantage over the currently used ones and can be made available not only for laboratory scale production but also for commercial production. Our study is also a well-suited example for the studies in which novel protein expression strategies are needed to achieve greater yields with higher purities.
Urgent Optic Nerve Decompression via an Endoscopic Endonasal Transsphenoidal Approach for Craniopharyngioma in a 12-Month-Old Infant: A Case Report
Authors: Shibata Teishiki , Tanikawa Motoki , Sakata Tomohiro , Mase Mitsuhito
Published: March 2018

Craniopharyngiomas are benign tumors and account for approximately 5.6–13% of all intracranial tumors in children. Diagnosis of pediatric craniopharyngioma is often delayed until the tumor becomes relatively large and manifests severe visual and/or endocrine disturbance. Endoscopic endonasal approaches have recently been introduced to surgery for craniopharyngioma. These techniques, however, have rarely been utilized in patients affected with craniopharyngioma as young as 1 year old. This report documents a 12-month-old male infant with sellar craniopharyngioma who presented with acute total vision loss. To increase the chances of visual recovery, an endoscopic endonasal optic nerve decompression was performed as an urgent procedure. After decompression, which resulted in improvement of his visual disturbance, gross total resection of the tumor was undertaken through an anterior interhemispheric approach at a later date. Tumor mass reduction through an endoscopic endonasal transsphenoidal approach followed by secondary radical total resection under craniotomy was considered to be useful in cases such as this when urgent optic nerve decompression is required.
Immune Cell Neurotrophin Production Is Associated with Subcortical Brain Atrophy in Neuropsychiatric Systemic Lupus Erythematosus Patients
Authors: Kalinowska-Łyszczarz Alicja , Pawlak Mikołaj A. , Wyciszkiewicz Aleksandra , Pawlak-Buś Katarzyna , Leszczyński Piotr , Puszczewicz Mariusz , Paprzycki Włodzimierz , Kozubski Wojciech , Michalak Sławomir
Published: March 2018

Objective: Central nervous system (CNS) involvement in systemic lupus erythematosus (SLE) remains poorly understood. Damage within the CNS is driven by the autoimmune response; however, immunopathophysiology of neuropsychiatric (NP) SLE is multifactorial. Immune cell neurotrophin production could be neuroprotective against autoimmunity-driven CNS damage, as has been shown in multiple sclerosis. The aim of this study was to establish whether immune cell neurotrophin production is associated with damage severity in NPSLE. Methods: Selected neurotrophins (BDNF, NGF, NT-3, and NT-4/5) were measured with ELISA within peripheral blood mononuclear cells (PBMCs) isolated from 38 NPSLE patients matched with 39 healthy controls. Subcortical and cortical structure volumes were segmented with the Freesurfer 5.3 pipeline on T1-weighted isotropic images acquired on a 1.5-T MRI scanner. Results: BDNF and NGF levels in PBMCs were reduced in NPSLE compared to the healthy population. The PBMC BDNF level was associated with reduced thalamus, caudate, and putamen volumes. The NGF level correlated with lateral ventricles enlargement and thalamic volume loss. Conclusions: In NPSLE, immune cell BDNF and NGF levels are linked with subcortical atrophy. Higher BDNF levels are associated with higher midsagittal atrophy, which may reflect compensatory mechanisms, upregulating BDNF when neuroprotection is needed. These data require further confirmation.
The 2017 Update of the German Clinical Guideline on Epidemiology, Diagnostics, Therapy, Prevention, and Management of Uncomplicated Urinary Tract Infections in Adult Patients. Part II: Therapy and Prevention
Authors: Kranz Jennifer , Schmidt Stefanie , Lebert Cordula , Schneidewind Laila , Mandraka Falitsa , Kunze Mirjam , Helbig Sina , Vahlensieck Winfried , Naber Kurt , Schmiemann Guido , Wagenlehner Florian M.
Published: March 2018

Background: We aimed to update the 2010 evidence- and consensus-based national clinical guideline on the diagnosis and management of uncomplicated urinary tract infections (UTIs) in adult patients. Results are published in 2 parts. Part 1 covers methods, the definition of patient groups, and diagnostics. This second publication focuses on treatment of acute episodes of cystitis and pyelonephritis as well as on prophylaxis of recurrent UTIs. Materials and Methods: An interdisciplinary group consisting of 17 representatives of 12 medical societies and a patient representative was formed. Systematic literature searches were conducted in MEDLINE, EMBASE, and the Cochrane Library to identify literature published in 2010–2015. Results: For the treatment of acute uncomplicated cystitis (AUC), fosfomycin-trometamol, nitrofurantoin, nitroxoline, pivmecillinam, and trimethoprim (depending on the local rate of resistance) are all equally recommended. Cotrimoxazole, fluoroquinolones, and cephalosporins are not recommended as antibiotics of first choice, for concern of an unfavorable impact on the microbiome. Mild to moderate uncomplicated pyelonephritis should be treated with oral cefpodoxime, ceftibuten, ciprofloxacin, or levofloxacin. For AUC with mild to moderate symptoms, instead of antibiotics symptomatic treatment alone may be considered depending on patient preference after discussing adverse events and outcomes. Primarily non-antibiotic options are recommended for prophylaxis of recurrent urinary tract infection. Conclusion: In accordance with the global antibiotic stewardship initiative and considering new insights in scientific research, we updated our German clinical UTI guideline to promote a responsible antibiotic use and to give clear hands-on recommendations for the diagnosis and management of UTIs in adults in Germany for healthcare providers and patients.