bluuebunny/crossref_metadata_2025 huggingface dataset:
From Biochemical Sensor to Wearable Device: The Key Role of the Conductive Polymer in the Triboelectric Nanogenerator
Authors: Zhao Zequan , Mi Yajun , Lu Yin , Zhu Qiliang , Cao Xia , Wang Ning
Published: June 2023

Triboelectric nanogenerators (TENGs) have revolutionized energy harvesting and active sensing, holding tremendous potential in personalized healthcare, sustainable diagnoses, and green energy applications. In these scenarios, conductive polymers play a vital role in enhancing the performance of both TENG and TENG-based biosensors, enabling the development of flexible, wearable, and highly sensitive diagnostic devices. This review summarizes the impact of conductive polymers on TENG-based sensors, focusing on their contributions to triboelectric properties, sensitivity, detection limits, and wearability. We discuss various strategies for incorporating conductive polymers into TENG-based biosensors, promoting the creation of innovative and customizable devices tailored for specific healthcare applications. Additionally, we consider the potential of integrating TENG-based sensors with energy storage devices, signal conditioning circuits, and wireless communication modules, ultimately leading to the development of advanced, self-powered diagnostic systems. Finally, we outline the challenges and future directions in developing TENGs that integrate conducting polymers for personalized healthcare, emphasizing the need to improve biocompatibility, stability, and device integration for practical applications.
Attachment-Related Differences in Emotion Regulation in Adults: A Systematic Review on Attachment Representations
Authors: Eilert Dirk W. , Buchheim Anna
Published: June 2023

In recent years, there has been an increase in the prevalence of mental disorders connected with affective dysregulation and insecure attachment. Therefore, it is even more important to understand the interplay between an individual’s attachment representation and patterns of emotion regulation. To our knowledge, this is the first systematic review to examine this association. PsycInfo, PsyArticles, and PubMed were searched for studies that examined attachment-related differences in emotion regulation in adults. To examine the unconscious attachment representation, only studies using the Adult Attachment Interview or the Adult Attachment Projective Picture System were included. Thirty-seven peer-reviewed studies (with a total of 2006 subjects) matched the PICO criteria. Emotion regulation was measured via four objective approaches: autonomic nervous system, brain activity, biochemistry, or nonverbal behavior. Across all measurements, results reveal a significant correlation between attachment representation and emotion regulation. Secure attachment correlates consistently with balanced emotion regulation, whereas it is impaired in insecure and dysfunctional in unresolved attachment. Specifically, unresolved individuals display counterintuitive responses and fail to use attachment as a resource. Insecure-dismissing attachment is associated with an emotionally deactivating strategy, while on a physiological, biochemical, and nonverbal level, emotional stress is still present. There is still a lack of studies examining preoccupied individuals. In addition to interpreting the results, we also discuss the risk of bias, implications for psychotherapy and coaching, and an outlook for future research.
Neuroanatomical Alterations in the CNTNAP2 Mouse Model of Autism Spectrum Disorder
Authors: Gandhi Tanya , Canepa Cade R. , Adeyelu Tolulope T. , Adeniyi Philip A. , Lee Charles C.
Published: June 2023

Autism spectrum disorder (ASD) is associated with neurodevelopmental alterations, including atypical forebrain cellular organization. Mutations in several ASD-related genes often result in cerebral cortical anomalies, such as the abnormal developmental migration of excitatory pyramidal cells and the malformation of inhibitory neuronal circuitry. Notably here, mutations in the CNTNAP2 gene result in ectopic superficial cortical neurons stalled in lower cortical layers and alterations to the balance of cortical excitation and inhibition. However, the broader circuit-level implications of these findings have not been previously investigated. Therefore, we assessed whether ectopic cortical neurons in CNTNAP2 mutant mice form aberrant connections with higher-order thalamic nuclei, potentially accounting for some autistic behaviors, such as repetitive and hyperactive behaviors. Furthermore, we assessed whether the development of parvalbumin-positive (PV) cortical interneurons and their specialized matrix support structures, called perineuronal nets (PNNs), were altered in these mutant mice. We found alterations in both ectopic neuronal connectivity and in the development of PNNs, PV neurons and PNNs enwrapping PV neurons in various sensory cortical regions and at different postnatal ages in the CNTNAP2 mutant mice, which likely lead to some of the cortical excitation/inhibition (E/I) imbalance associated with ASD. These findings suggest neuroanatomical alterations in cortical regions that underlie the emergence of ASD-related behaviors in this mouse model of the disorder.
How Social Norms Influence Purchasing Intention of Domestic Products: The Mediating Effects of Consumer Ethnocentrism and Domestic Product Judgments
Authors: Jia Qifan , Zhou Sizhe , Liu Run , Zuo Yihan , Pan Cuiyu , Chen Yu , Gong Yiyue , Chen Rui
Published: June 2023

Buying domestic products has become increasingly important in many countries. As a form of social influence, social norms affect people’s domestic purchasing intentions and behavior. The current study aims to examine the mechanisms by which social norms influence domestic purchasing intentions through the lens of consumer ethnocentrism and domestic product judgments. The data were collected through an online survey in China, and a total of 346 valid responses were obtained. The results indicate that social norms influence domestic purchasing intention through four paths, namely, direct path, motivational path, cognitive path, and motivational–cognitive path. Consumer ethnocentrism and domestic product judgments, serving as the motivational and cognitive factors, respectively, play mediating and serial mediating roles in the relationship between social norms and domestic purchasing intention. In addition, consumer ethnocentrism has two dimensions, namely, pro-domestic and anti-foreign consumer ethnocentrism, and only the former plays a significant role in the model. The current study has theoretical contributions to research on domestic purchasing intention and practical implications for interventions in domestic purchasing behavior. Future studies are encouraged to conduct experiments, distinguish between different types of social norms, measure purchasing behavior, and verify the relationships in other countries.
Nano-SiO2 Recycled Concrete Anti-Sulfate Performance and Damage Mechanism Research
Authors: Luo Jia , Wang Sheliang , Quan Xiaoyi , Xu Jin , Li Juntao , Liu Kangning , Xu Fan , Hong Zhilong
Published: June 2023

The use of construction waste for concrete is an effective way to reduce the environmental burden while improving the sustainability of construction materials. Nano-SiO2 (NS) has excellent volcanic ash activity, which can effectively improve the strength of concrete. In this study, the synergistic effects of NS and 30% recycled concrete aggregate (RCA) on the mass loss, compressive strength, ultrasonic sound velocity values and microstructure of RAC after 25, 50, 75 and 100 repetitions of a dry–wet cycle (DWC) of sulfuric acid were investigated. The results show that NS has a significant role in improving RAC performance. The RAC specimens showed the lowest mass loss rate, the highest compressive strength, the lowest ultrasonic velocity value and the best resistance to sulfate erosion when the NS doping was 4%. Meanwhile, under CT and SEM, RAC with NS has lower porosity and higher hydration, which can effectively inhibit the crack generation and has stable volume growth within 0–50 repetitions of DWC. In addition, the addition of NS improves not only the microstructure of the substrate but also the interfacial transition zone (ITZ). When 4% NS was added, the porosity was the lowest and the durability improvement was the best performance. This study not only improves the production performance of RAC but also provides a strong reference for the integrated application of nanomaterials in concrete.
Experimental Study on CO2 and Radon Mitigations in an Apartment Using a Mechanical Ventilation System
Authors: Jeong Jinhee , Cho Kyungjoo
Published: June 2023

The public interest in indoor air quality has rapidly increased in Korean society, and ventilation systems can play an essential role in improving indoor air quality. This study aims to estimate the reduction in indoor CO2 and radon, which can be effectively mitigated by air exchange, according to the operation of mechanical ventilation in an apartment with the national standard housing size (85 m2) and shape in Korea. The time required to meet Korea’s mandatory indoor CO2 standard (1000 ppm) was 167, 98, 66, and 51 min under air change rates of 0.5, 1.0, 1.5, and 2.0 ACH (air change per hour), respectively. Regarding indoor radon, the removal rate increased with increased ventilation volume, and the minimum concentration level was low and sustained for a prolonged duration. Nonetheless, an air change rate of 0.5 ACH may not offer sufficient ventilation. Additionally, it is imperative to note that indoor radon concentrations tend to escalate swiftly when a mechanical ventilation system is deactivated. Thus, to enhance indoor air quality, it is necessary to reconsider strategies to augment the air change rate and guarantee uninterrupted ventilation.
Megaproject Governance Research in China: A Review and Visual Analysis from the Whole Life Cycle Perspective
Authors: Ding Jiyong , Zhang Guiyu , Sun Meng
Published: June 2023

At present, the number of megaprojects in China is rapidly increasing, with multiple projects ranked as the world’s highest. To showcase the theoretical and practical achievements of China’s megaprojects to the world, a visual analysis was carried out using CiteSpace software based on data from 520 pieces of core literature related to megaproject governance in the CNKI database from 2001 to 2023. Our findings indicate that: the number of publications has significantly increased since 2016, with a core group of researchers significantly contributing to this field, while team collaboration needs to be strengthened; the research hotspots include social stability risks, transaction governance, and innovation in megaprojects; the research can be divided into three stages, starting with early macro-studies, gradually forming clear and hierarchical research branches, and beginning to develop in the direction of Chinese characteristics and innovative deepening in recent years; research on the megaproject governance system is becoming gradually more enriched, but there is a lack of research at the levels of top-level governance and operational governance. Finally, in order to advance the study of megaproject governance in China, future research directions are suggested.
Mechanical Properties of Cement Mortars Reinforced with Polypropylene Fibers Subjected to High Temperatures and Different Cooling Regimes
Authors: Alvarez Yorly , Prieto María Isabel , Cobo Alfonso
Published: June 2023

This study experimentally investigated the mechanical properties of cement mortars that were reinforced with polypropylene (PP) fibers after being exposed to high temperatures and cooled under different regimes. PP fibers were added in amounts of 2, 3 and 4 kg/m3, the residual strengths of the mortars exposed to various temperatures up to 500 °C and cooled under different regimes were determined. It was found that the addition of PP fiber at the level of 2 kg/m3 improves the residual flexural and compressive strengths up to 300 °C. The residual flexural strength was approximately 75%, which is 15% higher than that observed in the simple mortar, and the same happens with the residual compressive strength which was approximately 85%, which is 17% higher than that observed in the simple mortar, regardless of the types of cooling used on the specimens. It was determined by means of a statistical analysis that there are no significant differences in the mechanical properties of the mortar according to the cooling regimes used, after having been exposed to high temperatures. The correlation of the residual flexural and compressive strengths was achieved with a coefficient of determination, R2 = 0.82, and the relationships between the variables were considered acceptable regardless of the types of cooling used.
Innovation Pattern Heterogeneity and Crisis Resilience
Authors: Rybalka Marina , Mark Michael Spjelkavik
Published: June 2023

We use the new taxonomy for innovative firms developed based on microlevel data from the Community Innovation Survey (CIS2018) on a sample of 6360 Norwegian firms, and information on users of COVID-19-related compensation schemes for firms with significant loss of turnover and furloughed employees to analyse how resilient different innovative firms have been to the crisis (in both the short and the long run). By using different probabilistic regression models, we study the probability of firms being affected negatively during the pandemic period between March 2020 and February 2022 covering three waves of societal restrictions in Norway. Our main assumption is that all firms were hit by a shock at an early stage due to a complete lockdown in March 2020, but that firms were more resilient if they either did not use the compensation schemes or used them for a briefer period than the less resilient firms. We find “active R&D doers” to be most resilient, while “strategic adapters” (firms with a main strategy of producing high-quality products for a specific group of customers) are found to be least resilient. These results imply that pre-existing innovation capabilities are important for meeting the crisis.
From Waste to Resource: Utilizing Sweet Chestnut Waste to Produce Hydrothermal Carbon for Water Decontamination
Authors: Izquierdo Silvia , Pacheco Nazaret , Durán-Valle Carlos J. , López-Coca Ignacio M.
Published: June 2023

Carbonaceous materials are a highly appealing class of adsorbents, owing to their exceptional properties, such as high surface area and thermal and chemical stability. These materials have found successful applications in water purification. Sweet chestnut (Castanea sativa) cupules are disposed of as waste. Valorization of these residues is a step forward in terms of circular economy and sustainability. Meanwhile, per- and poly-fluoroalkyl substances (PFASs) pose significant concerns due to their persistence, bioaccumulation, and toxicity, emerging as contaminants of concern for human health and the environment. This study focuses on preparing carbonaceous material by hydrothermal carbonization from chestnut cupules, followed by their use as adsorbents for PFAS removal from polluted water. The cupule waste material was crushed, ground, sieved, and subjected to hydrothermal treatment at temperatures ranging from 180–200 °C to produce hydrothermal carbons. The adsorbents obtained were characterized by various techniques such as nitrogen adsorption isotherm, porosimetry, point of zero charge, Fourier-transform infrared, scanning electron microscopy, and thermal, elemental, and energy dispersive X-ray analyses. Surface area (SBET) values of 42.3–53.2 m2·g−1 were obtained; pHPZC ranged from 3.8 to 4.8. This study also determined the adsorption kinetics and isotherms for removing perfluorooctanoate-contaminated water. The equilibrium was established at 72 h and qe = 1029.47 mg·g−1. To summarize, this research successfully valorized a biomass residue by transforming it into hydrothermal carbon, which was then utilized as an adsorbent for water decontamination.
Diagnostic Value of the Texture Analysis Parameters of Retroperitoneal Residual Masses on Computed Tomographic Scan after Chemotherapy in Non-Seminomatous Germ Cell Tumors
Authors: Fournier Clémence , Leguillette Clémence , Leblanc Eric , Le Deley Marie-Cécile , Carnot Aurélien , Pasquier David , Escande Alexandre , Taieb Sophie , Ceugnart Luc , Lebellec Loïc
Published: June 2023

After chemotherapy, patients with non-seminomatous germ cell tumors (NSGCTs) with residual masses >1 cm on computed tomography (CT) undergo surgery. However, in approximately 50% of cases, these masses only consist of necrosis/fibrosis. We aimed to develop a radiomics score to predict the malignant character of residual masses to avoid surgical overtreatment. Patients with NSGCTs who underwent surgery for residual masses between September 2007 and July 2020 were retrospectively identified from a unicenter database. Residual masses were delineated on post-chemotherapy contrast-enhanced CT scans. Tumor textures were obtained using the free software LifeX. We constructed a radiomics score using a penalized logistic regression model in a training dataset, and evaluated its performance on a test dataset. We included 76 patients, with 149 residual masses; 97 masses were malignant (65%). In the training dataset (n = 99 residual masses), the best model (ELASTIC-NET) led to a radiomics score based on eight texture features. In the test dataset, the area under the curve (AUC), sensibility, and specificity of this model were respectively estimated at 0.82 (95%CI, 0.69–0.95), 90.6% (75.0–98.0), and 61.1% (35.7–82.7). Our radiomics score may help in the prediction of the malignant nature of residual post-chemotherapy masses in NSGCTs before surgery, and thus limit overtreatment. However, these results are insufficient to simply select patients for surgery.
Risk of Oral Squamous Cell Carcinoma in One Hundred Patients with Oral Lichen Planus: A Follow-Up Study of Umberto I University Hospital of Rome
Authors: Tenore Gianluca , Mohsen Ahmed , Rocchetti Federica , Rossi Giulia , Cassoni Andrea , Battisti Andrea , Della Monaca Marco , Di Gioia Cira Rosaria Tiziana , De Felice Francesca , Botticelli Andrea , Valentini Valentino , Della Rocca Carlo , De Vincentiis Marco , Polimeni Antonella , Romeo Umberto
Published: June 2023

This study aims to retrospectively assess the potential risk of malignant transformation in patients with diagnosed oral lichen planus (OLP) between 2015 and 2022, and to evaluate the influence of different risk factors. The department’s database and medical records from 2015 to 2022 were searched for patients with a confirmed diagnosis of OLP based on both clinical and histological parameters. A total of 100 patients (59 females and 41 males) were found with a mean age of 64.03 years. In the considered period, the percentage of diagnosed OLP patients was 1.6%, while the percentage of diagnosed OLP patients with transformation to oral squamous cell carcinoma (OSCC) was 0.18%. A statistically significant difference was found with age (p = 0.038), tobacco status (p = 0.022), and radiotherapy (p = 0.041). The analysis revealed the presence of significant risk in ex-smokers (>20 pack-years), with an odds ratio (OR) of 10.0000 (95% confidence interval (95% CI) 1.5793–63.3186); in alcohol-drinker patients, with an OR of 4.0519 (95% CI 1.0182–16.1253); in ex-smoker and alcohol-drinker patients, with OR of 17.6250 (95% CI 2.2464–138.2808); and in patients who had undergone radiotherapy, with OR of 6.3000 (95% CI 1.2661–31.3484). The malignant transformation of oral lichen planus was slightly higher than thought, and the results revealed a possible association with age, tobacco and alcohol status, and history of radiotherapy. An elevated risk of malignant transformation was observed in heavy ex-smoker patients, alcohol-drinker patients, and alcohol-drinker patients with a history of smoking (ex-smokers). Persuading the patient to quit tobacco and alcohol consumption and periodic follow-ups are recommended in general, but particularly in the presence of these risk factors.
The Structural Dynamics, Complexity of Interactions, and Functions in Cancer of Multi-SAM Containing Proteins
Authors: Clements Christopher M. , Henen Morkos A. , Vögeli Beat , Shellman Yiqun G.
Published: June 2023

SAM domains are crucial mediators of diverse interactions, including those important for tumorigenesis or metastasis of cancers, and thus SAM domains can be attractive targets for developing cancer therapies. This review aims to explore the literature, especially on the recent findings of the structural dynamics, regulation, and functions of SAM domains in proteins containing more than one SAM (multi-SAM containing proteins, MSCPs). The topics here include how intrinsic disorder of some SAMs and an additional SAM domain in MSCPs increase the complexity of their interactions and oligomerization arrangements. Many similarities exist among these MSCPs, including their effects on cancer cell adhesion, migration, and metastasis. In addition, they are all involved in some types of receptor-mediated signaling and neurology-related functions or diseases, although the specific receptors and functions vary. This review also provides a simple outline of methods for studying protein domains, which may help non-structural biologists to reach out and build new collaborations to study their favorite protein domains/regions. Overall, this review aims to provide representative examples of various scenarios that may provide clues to better understand the roles of SAM domains and MSCPs in cancer in general.
Evaluating Differentiation Status of Mesenchymal Stem Cells by Label-Free Microscopy System and Machine Learning
Authors: Kong Yawei , Ao Jianpeng , Chen Qiushu , Su Wenhua , Zhao Yinping , Fei Yiyan , Ma Jiong , Ji Minbiao , Mi Lan
Published: June 2023

Mesenchymal stem cells (MSCs) play a crucial role in tissue engineering, as their differentiation status directly affects the quality of the final cultured tissue, which is critical to the success of transplantation therapy. Furthermore, the precise control of MSC differentiation is essential for stem cell therapy in clinical settings, as low-purity stem cells can lead to tumorigenic problems. Therefore, to address the heterogeneity of MSCs during their differentiation into adipogenic or osteogenic lineages, numerous label-free microscopic images were acquired using fluorescence lifetime imaging microscopy (FLIM) and stimulated Raman scattering (SRS), and an automated evaluation model for the differentiation status of MSCs was built based on the K-means machine learning algorithm. The model is capable of highly sensitive analysis of individual cell differentiation status, so it has great potential for stem cell differentiation research.
The Anion Impact on Dimensionality of Cadmium(II) Complexes with Nicotinamide
Authors: Soldin Željka , Kukovec Boris-Marko , Kovačić Milica , Đaković Marijana , Popović Zora
Published: June 2023

Three novel cadmium(II) coordination compounds, the dimeric [Cd(CH3COO)2(nia)2]2 (1), the polymeric {[Cd(nia)4](ClO4)2}n (2), and the monomeric [Cd(H2O)3(nia)3](ClO4)2·nia (3), were prepared in the reactions of the nicotinamide (pyridine-3-carboxamide, nia) with the corresponding cadmium(II) salts. All prepared compounds were characterized by elemental analyses, FT-IR spectroscopy, TGA/DTA, and single crystal X-ray analysis. The impact of anions (acetate, perchlorate) and solvent used on the dimensionality of cadmium(II) complexes and the cadmium(II) coordination environment was investigated. The bridging capabilities of acetate ions enabled the formation of dimers in the crystal structure of 1. It was shown that the dimensionality of perchlorate complexes depends on the solvent used. The coordination polymer 2 is isolated from an ethanol solution, while monomeric compound 3 was obtained by using a water/ethanol mixture as a solvent. The pentagonal-bipyramidal coordination of cadmium(II) was found in the presence of chelating and bridging acetate ions in 1. In the presence of non-coordinating perchlorate anions in 2 and 3, the coordination geometry of cadmium(II) is found to be octahedral. The supramolecular amide-amide homosynthon R22(8) was preserved in the hydrogen-bonded frameworks of all three compounds.
Is There an Association between BMI, Height, and Gender and Long-Bone Fractures during Childhood and Adolescence? A Large Cross-Sectional Population Study of 911,206 Subjects
Authors: Lotan Raphael , Thein Ran , Gordon Barak , Tenenbaum Shay , Derazne Estela , Tzur Dorit , Afek Arnon , Hershkovich Oded
Published: June 2023

Introduction: Traumatic long-bone fractures (TLFs) among children and adolescents are relatively common, with morbidity and economic consequences. Obesity has become a significant global concern. Studies have found an association between TLFs and BMI in the past but not in a large cross-sectional population study. Our study objective was to measure the incidence of TLFs in the 17-year-old general population and evaluate its association with BMI, body height, and gender. Methods: Data from a medical database containing all 17-year-old candidates’ records before recruitment into mandatory military service were retrieved as BMI, height, gender, and history of TLFs. Logistic regression models assessed the association between BMI and height to TLFs. Results: The records of 911,206 subjects (515,339 males) were reviewed. In total, 9.65% had a history of TLFs (12.25% and 6.25% for males/females, respectively). Higher BMI was associated with TLF, with a linear trend in the odds ratio (OR) for having TLFs. The strongest association was found between obese females and TLFs (OR = 1.364, p < 0.0001). Height was an independent factor positively associated with TLFs. The OR for a TLF in the highest height quintile was 1.238 (p < 0.001) for males and 1.411 (p < 0.001) for females compared to the lowest quintile. Although TLFs were more common in males, the OR for TLFs was more prominent in females. Conclusions: There is an association between BMI, body height, and TLFs in healthy adolescents. TLFs are more common in males, but the strongest association between overweight and obesity is evident in females.
Breastfeeding and Complementary Feeding Practices among Caregivers at Seshego Zone 4 Clinic in Limpopo Province, South Africa
Authors: Mphasha M. H. , Makwela M. S. , Muleka N. , Maanaso B. , Phoku M. M.
Published: June 2023

Breastfeeding and complementary feeding are key components of infant and young child feeding that ensure healthy growth, survival, and development. Initiating breastfeeding within an hour after delivery, exclusively breastfeeding for six months, and introducing complementary feeding at six months while continuing breastfeeding up to 24 months or beyond, helps in the prevention of malnutrition, which is a public health problem. The aim of this study was to determine breastfeeding and complementary feeding practices among caregivers of children under 24 months in Seshego, Limpopo Province. A quantitative and cross-sectional design was applied to collect data from 86 caregivers using convenience sampling. A structured questionnaire was utilised to gather data and analysed through statistical software, using descriptive and inferential statistics. Chi-square tests were used to determine associations at a 95% confidence interval where a p-value of <0.05 was considered statistically significant. The findings show that 55% of participants had good breastfeeding and complementary feeding practices. Moreover, 94.2% of participants breastfeed within an hour after delivery at a healthcare facility. Only 43.6% of children were exclusively breastfed. Most participants (52.3%) gave children food before six months and 45.1% introduced complementary feeding at the appropriate age. Also, 69.7% of children across all age groups were not given infant formula. No statistical association was observed between feeding practices and sociodemographic. Breastfeeding was initiated within an hour after delivery at the healthcare facilities, however, post discharge exclusive breastfeeding maintenance remains a challenge. Few infants were introduced to complementary feeding at the appropriate age. A post discharge intervention to practice exclusive breastfeeding, continued breastfeeding, and introduction of appropriate complementary feeding is recommended.
Differential Diagnosis of ICD-11 Personality Disorder and Autism Spectrum Disorder in Adolescents
Authors: Bach Bo , Vestergaard Martin
Published: June 2023

The International Classification of Diseases 11th Revision (ICD-11) introduces fundamentally new diagnostic descriptions for personality disorder and autism spectrum disorder. Instead of the traditional categorical taxonomies, both personality disorder and autism spectrum disorder are described as being on a continuum. Accumulating research has pointed out that, in some cases, adolescents with autism spectrum disorder are at risk of being confused with having a personality disorder, which particularly applies to female adolescents. Case reports describe how adult autistic women struggled with social and identity roles as children and adolescents, using compensatory strategies such as social imitation and other types of camouflaging. Furthermore, some adolescents with autism display emotion dysregulation and self-injury. The ICD-11 recognizes that features of autism spectrum disorder may resemble features of personality disorder, but the two diagnoses have not yet been formally compared to one another. The present article therefore sought to outline and discuss the overlap and boundaries between the ICD-11 definitions of personality disorder and autism spectrum disorder and propose guiding principles that may assist practitioners in differential diagnosis with female adolescents. We specifically highlight how aspects of the self and interpersonal functioning along with emotional, cognitive, and behavioral manifestations may overlap across the two diagnoses. Restricted, repetitive, and inflexible patterns of behavior, interests, and activities are core features of autism spectrum disorder, which may be masked or less pronounced in female adolescents. Collecting a developmental history of the early presence or absence of autistic features is vital for a conclusive diagnosis, including features that are typically camouflaged in females. A number of future directions for research and clinical practice are proposed.
Genetic Dissection of Salt Tolerance and Yield Traits of Geng (japonica) Rice by Selective Subspecific Introgression
Authors: Li Simin , Feng Ting , Zhang Chenyang , Zhang Fanlin , Li Hua , Chen Yanjun , Liang Lunping , Zhang Chaopu , Zeng Wei , Liu Erbao , Shi Yingyao , Li Min , Meng Lijun
Published: June 2023

Salinity is a major factor limiting rice productivity, and developing salt-tolerant (ST) varieties is the most efficient approach. Seventy-eight ST introgression lines (ILs), including nine promising lines with improved ST and yield potential (YP), were developed from four BC2F4 populations from inter-subspecific crosses between an elite Geng (japonica) recipient and four Xian (indica) donors at the Institute of Crop Sciences, Chinese Academy of Agricultural Sciences. Genome-wide characterization of donor introgression identified 35 ST QTLs, 25 of which harbor 38 cloned ST genes as the most likely QTL candidates. Thirty-four are Xian-Geng differentiated ones with the donor (Xian) alleles associated with ST, suggesting differentiated responses to salt stress were one of the major phenotypic differences between the two subspecies. At least eight ST QTLs and many others affecting yield traits were identified under salt/non-stress conditions. Our results indicated that the Xian gene pool contains rich ‘hidden’ genetic variation for developing superior Geng varieties with improved ST and YP, which could be efficiently exploited by selective introgression. The developed ST ILs and their genetic information on the donor alleles for ST and yield traits would provide a useful platform for developing superior ST and high-yield Geng varieties through breeding by design in the future.
Processing and Analysis of Micro-Arc Oxidation Coating on 319S Aluminum Alloy
Authors: Lv Pengxiang , Zhang Xiaozhou , Yin Tingting , Wang Zhen , Dong Qi , He Li , Zheng Shuangyang
Published: June 2023

In this study, a high-hardness and wear-resistant ceramic coating was prepared on the surface of 319S aluminum alloy using the micro-arc oxidation (MAO) technique. The effects of pulse width, negative voltage, and KOH concentration on the MAO coating were investigated, and the microhardness and surface roughness of the coating were measured. The morphology, elemental distribution, and phase composition of the coating were analyzed using SEM, EDS, XRD, and digital microscopy. The influence of the MAO coating on the wear of the 319S aluminum alloy was evaluated using a friction-wear tester. The results showed that in the sodium silicate solution system, with an increase in pulse width, the thickness of the coating gradually increased and the surface hardness initially increased and then decreased. With an increase in negative voltage, the density of the coating first increased and then decreased, the thickness of the dense layer initially increased and then decreased, and the surface hardness initially increased and then decreased. With an increase in the KOH concentration, the coating thickness increased and the roughness initially decreased and then increased. When the pulse width was 3000 ms, the negative voltage was 130 V, and the KOH concentration was 1 g/L, the coating exhibited the best density, with the highest surface hardness of 1426.8 HV and the thickest dense layer of 55 μm. The reduction in surface cracks and improvement in density indicated an enhancement in the hardness and wear resistance of the coating. The decrease in width and depth of the wear scars demonstrated the excellent wear resistance of the coating.
COVID-19 Seroprevalence in a Mixed Cohort of SARS-CoV-2 PCR Positive and Exposed Subjects
Authors: Knowles Giles , Winkie Colin , Umer Amna , Moffett Kathryn , Weisse Martin , Gupta Shipra
Published: June 2023

Early in the SARS-CoV-2 pandemic, polymerase chain reaction (PCR) testing was reserved for symptomatic patients. However, many infections were asymptomatic or mildly symptomatic. Positive serologic antibody (Ab) testing is theorized to be a marker of prior infection, allowing for identification of the true burden of the disease and the establishment of links between outbreaks. The objective was to assess serologic testing in subjects after PCR testing and compare seropositivity rates of household vs. non-household close contacts. We identified subjects who were PCR-positive between March 2020 and May 2021. Index cases and close contacts then underwent serologic testing for IgG against the SARS-CoV-2 nucleocapsid N-protein. One hundred and thirteen subjects underwent serologic testing with a sensitivity of 65.0%, specificity of 78.9%, positive predictive value of 92.9%, and negative predictive value of 34.9%. Index cases comprised 20.5% of subjects, and 73.9% were seropositive (p = 0.01). Close contacts included 72% household contacts and 28% non-household contacts. One seropositive case had no prior PCR and four were PCR negative. No statistical difference existed in seropositivity between household and non-household contact (53.1% vs. 43.8%, p = 0.4). Testing for IgG against SARS-CoV-2 N-protein may identify previously unrecognized infections in the community. Seropositivity rates of household vs. non-household contacts were not significantly different, and >50% of household contacts were seropositive.
Selinexor and Other Selective Inhibitors of Nuclear Export (SINEs)—A Novel Approach to Target Hematologic Malignancies and Solid Tumors
Authors: Karaszewski Kajetan , Jędrzejczak Wiesław Wiktor
Published: June 2023

Exportin 1 (XPO1) is a crucial molecule of nucleocytoplasmic transport. Among others, it exports molecules important for oncogenesis from the nucleus to the cytoplasm. The expression of XPO1 is increased in numerous malignancies, which contributes to the abnormal localization of tumor suppressor proteins in the cytoplasm and subsequent cell cycle dysregulation. Selective inhibitors of nuclear export (SINEs) are novel anticancer agents that target XPO1, arrest tumor suppressor proteins in the nucleus, and induce apoptosis in cancer cells. Selinexor, a first-in-class SINE, has already been approved for the treatment of relapsed/refractory multiple myeloma and relapsed/refractory diffuse large B cell lymphoma not otherwise specified. It has also been proven effective in relapsed/refractory and previously untreated acute myeloid leukemia patients. In addition, numerous studies have yielded promising results in other malignancies of the hematopoietic system and solid tumors. However, future clinical use of selinexor and other SINEs may be hampered by their significant toxicity.
Ultrasound Imaging and Guidance for Distal Peripheral Nerve Pathologies at the Wrist/Hand
Authors: Wu Wei-Ting , Chang Ke-Vin , Hsu Yu-Chun , Tsai Yuan-Yuan , Mezian Kamal , Ricci Vincenzo , Özçakar Levent
Published: June 2023

Ultrasound has emerged as a highly valuable tool in imaging peripheral nerve lesions in the wrist region, particularly for common pathologies such as carpal tunnel and Guyon’s canal syndromes. Extensive research has demonstrated nerve swelling proximal to the entrapment site, an unclear border, and flattening as features of nerve entrapments. However, there is a dearth of information regarding small or terminal nerves in the wrist and hand. This article aims to bridge this knowledge gap by providing a comprehensive overview concerning scanning techniques, pathology, and guided-injection methods for those nerve entrapments. The median nerve (main trunk, palmar cutaneous branch, and recurrent motor branch), ulnar nerve (main trunk, superficial branch, deep branch, palmar ulnar cutaneous branch, and dorsal ulnar cutaneous branch), superficial radial nerve, posterior interosseous nerve, palmar common/proper digital nerves, and dorsal common/proper digital nerves are elaborated in this review. A series of ultrasound images are used to illustrate these techniques in detail. Finally, sonographic findings complement electrodiagnostic studies, providing better insight into understanding the whole clinical scenario, while ultrasound-guided interventions are safe and effective for treating relevant nerve pathologies.
Validation of a Length-Adjusted Abdominal Arterial Calcium Score Method for Contrast-Enhanced CT Scans
Authors: Devia-Rodriguez Raul , Derksen Maikel , de Groot Kristian , Vedder Issi R. , Zeebregts Clark J. , Bokkers Reinoud P. H. , Pol Robert A. , de Vries Jean-Paul P. M. , Schuurmann Richte C. L.
Published: June 2023

Background: The Agatston score on noncontrast computed tomography (CT) scans is the gold standard for calcium load determination. However, contrast-enhanced CT is commonly used for patients with atherosclerotic cardiovascular diseases (ASCVDs), such as peripheral arterial occlusive disease (PAOD) and abdominal aortic aneurysm (AAA). Currently, there is no validated method to determine calcium load in the aorta and peripheral arteries with a contrast-enhanced CT. This study validated a length-adjusted calcium score (LACS) method for contrast-enhanced CT scans. Method: The LACS (calcium volume in mm3/arterial length in cm) in the abdominal aorta was calculated using four-phase liver CT scans of 30 patients treated between 2017 and 2021 at the University Medical Center Groningen (UMCG) with no aortic disease. Noncontrast CT scans were segmented with a 130 Hounsfield units (HU) threshold, and a patient-specific threshold was used for contrast-enhanced CTs. The LACS was calculated and compared from both segmentations. Secondly, the interobserver variability and the influence of slice thickness (0.75 mm vs. 2.0 mm) was determined. Results: There was a high correlation between the LACS from contrast-enhanced CT scans and the LACS of noncontrast CTs (R2 = 0.98). A correction factor of 1.9 was established to convert the LACS derived from contrast-enhanced CT to noncontrast CT scans. LACS interobserver agreement on contrast-enhanced CT was excellent (1.0, 95% confidence interval = 1.0–1.0). The 0.75 mm CT threshold was 541 (459–625) HU compared with 500 (419–568) HU on 2 mm CTs (p = 0.15). LACS calculated with both thresholds was not significantly different (p = 0.63). Conclusion: The LACS seems to be a robust method for scoring calcium load on contrast-enhanced CT scans in arterial segments with various lengths.
Impact of the FilmArray Rapid Multiplex PCR Assay on Clinical Outcomes of Patients with Bacteremia
Authors: Okamoto Mai , Maejima Makoto , Goto Taichiro , Mikawa Takahiro , Hosaka Kazuhiro , Nagakubo Yuki , Hirotsu Yosuke , Amemiya Kenji , Sueki Hitomi , Omata Masao
Published: June 2023

Bacteremia is a serious disease with a reported mortality of 30%. Appropriate antibiotic use with a prompt blood culture can improve patient survival. However, when bacterial identification tests based on conventional biochemical properties are used, it takes 2 to 3 days from positive blood culture conversion to reporting the results, which makes early intervention difficult. Recently, FilmArray (FA) multiplex PCR panel for blood culture identification was introduced to the clinical setting. In this study, we investigated the clinical impact of the FA system on decision making for treating septic diseases and its association with patients’ survival. Our hospital introduced the FA multiplex PCR panel in July 2018. In this study, blood-culture-positive cases submitted between January and October 2018 were unbiasedly included, and clinical outcomes before and after the introduction of FA were compared. The outcomes included (i) the duration of use of broad-spectrum antibiotics, (ii) the time until the start of anti-MRSA therapy to MRSA bacteremia, and (iii) sixty-day overall survival. In addition, multivariate analysis was used to identify prognostic factors. In the FA group, overall, 122 (87.8%) microorganisms were concordantly retrieved with the FA identification panel. The duration of ABPC/SBT use and the start-up time of anti-MRSA therapy to MRSA bacteremia were significantly shorter in the FA group. Sixty-day overall survival was significantly improved by utilizing FA compared with the control group. In addition, multivariate analysis identified Pitt score, Charlson score, and utilization of FA as prognostic factors. In conclusion, FA can lead to the prompt bacterial identification of bacteremia and its effective treatment, thus significantly improving survival in patients with bacteremia.
Hybrid Deep Learning Approach for Stress Detection Using Decomposed EEG Signals
Authors: Roy Bishwajit , Malviya Lokesh , Kumar Radhikesh , Mal Sandip , Kumar Amrendra , Bhowmik Tanmay , Hu Jong Wan
Published: June 2023

Stress has an impact, not only on a person’s physical health, but also on the ability to perform at the workplace in daily life. The well-established relation between psychological stress and its pathogeneses highlights the need for detecting psychological stress early, in order to prevent disease advancement and to save human lives. Electroencephalography (EEG) signal recording tools are widely used to collect these psychological signals/brain rhythms in the form of electric waves. The aim of the current research was to apply automatic feature extraction to decomposed multichannel EEG recordings, in order to efficiently detect psychological stress. The traditional deep learning techniques, namely the convolution neural network (CNN), long short-term memory (LSTM), bidirectional long short-term memory (BiLSTM), gated recurrent unit (GRU) and recurrent neural network (RNN) models, have been frequently used for stress detection. A hybrid combination of these techniques may provide improved performance, and can handle long-term dependencies in non-linear brain signals. Therefore, this study proposed an integration of deep learning models, called DWT-based CNN, BiLSTM, and two layers of a GRU network, to extract features and classify stress levels. Discrete wavelet transform (DWT) analysis was used to remove the non-linearity and non-stationarity from multi-channel (14 channel) EEG recordings, and to decompose them into different frequency bands. The decomposed signals were utilized for automatic feature extraction using the CNN, and the stress levels were classified using BiLSTM and two layers of GRU. This study compared five combinations of the CNN, LSTM, BiLSTM, GRU and RNN models with the proposed model. The proposed hybrid model performed better in classification accuracy compared to the other models. Therefore, hybrid combinations are appropriate for the clinical intervention and prevention of mental and physical problems.
Dental, Skeletal, and Soft Tissue Changes after Bone-Borne Surgically Assisted Rapid Maxillary Expansion: A Systematic Review and Meta-Analysis
Authors: Sekertzi Christina , Koukouviti Maria-Marina , Chatzigianni Athina , Kolokitha Olga-Elpis
Published: June 2023

(1) Background: For non-growing patients with marked transverse maxillary deficiency, bone-borne surgically assisted rapid maxillary expansion (SARME) has been proposed as an effective treatment option. Objective: To evaluate the dental, skeletal, and soft tissue changes following bone-borne SARME. (2) Methods: An unrestricted systematic electronic search of six databases, supplemented by manual searches, was performed up to April 2023. The eligibility criteria included prospective/retrospective clinical studies with outcomes pertaining to objective measurements of dental/skeletal/soft tissue effects of bone-borne SARME in healthy patients. (3) Results: Overall, 27 studies satisfied the inclusion criteria. The risk of bias of the non-randomized trials ranged between moderate (20) and serious (4). For the two RCTs, there were some concerns of bias. Trials with outcomes measured at the same landmarks within the scope of the prespecified timeframe were deemed eligible for quantitative synthesis. Eventually, five trials were included in the meta-analysis. SARME was associated with a statistically significant lengthening of the dental arch perimeter immediately after expansion, along with a marginally significant decrease in palatal depth during the post-SARME retention period. Post-treatment SNA values exhibited no statistically significant change. (4) Conclusion: Current evidence indicates that bone-borne SARME constitutes an effective treatment option for adult patients with maxillary transverse deficiency. Further long-term randomized clinical trials with robust methodology, large sample sizes, and 3D evaluation of the outcomes are needed.
Correction: Mohamed et al. Gusts Encountered by Flying Vehicles in Proximity to Buildings. Drones 2023, 7, 22
Authors: Mohamed Abdulghani , Marino Matthew , Watkins Simon , Jaworski Justin , Jones Anya
Published: June 2023

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