bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemoprofiling and In vitro antioxidant potentials of methanol water extracts from Nigerian ginger (Zingiber officinale)
Authors: Osibote E. A. , Ojikutu A. S . , Adeyemo O. A. , Nwankwo N. J.
Published: May 2023

Ginger (Zingiber officinale) is one of the popular spices in Nigeria. It is highly utilised over the world as spice as well as for the treatment of inflammation, arthritis and other conditions involving reactive oxygen species (ROS), which are known to damage human cells. The proximate, phytochemical composition and antioxidant properties of the plant are reported in this work. Extraction by maceration was used for the pulverized rhizomes with methanol-water (50:50). Further partitioning of the extract was carried out using n-hexane, ethyl acetate and butanol into different fractions according to their polarity. The antioxidant activity was evaluated with 1,1-diphenyl-2-icrylhydrazyl (DPPH) radical scavenging assay, ferric reducing antioxidant power (FRAP) assay, nitric oxide radical scavenging activity (NOSA) and lipid peroxidation scavenging activity (LPSA). The proximate content was determined using conventional chemical methods. The FTIR analyses of n-hexane fraction of Z. officinale revealed some functional groups that may be present in two likely classes of secondary metabolites: terpenes and alkaloids. The ethyl acetate fraction produced flavonoid (121.31 mg/100 g; quercetin) and alkaloids because of the functional groups associated with them, while the butanol fraction with functional groups present revealed cardiac glycosides (4.88 mg/100 g; digoxin) and alkaloids (45.19 mg/100 g). The plant also contained reducing sugar (64.62 mg/100 g glucose), steroids (8.65 mg/100 g; cholesterol), tannins (56.82 mg/100 g; tannic acid) and phenolic compounds (110.64 mg/100 g; gallic acid) from the phytochemical analyses. The proximate analysis revealed that it has a high carbohydrate content (54.54%), but a relatively modest crude fibre (10.21%), moisture content (10.02%), total ash (9.30%), crude fat (8.80%) and crude protein (7.12%). The presence of these phyto-compounds could explain its customary use as oxidative stress inhibitor.
Integral representations of the generating function of the Riemann zeta function of integer arguments
Authors: Adegoke K. , Olatinwo A.
Published: May 2023

In this article we give new integral representations for the ordinary generating functions of ζ(2n), nζ(2n+1) and ζ(2n+1) for n∈ Z*, n≥1; where  ζ(j) is the Riemann zeta function. We also give closed form expressionsfor the generating functions.
Microstructural interpretation of the garnet-sillimanite-bearing granite gneiss of Ikare area, southwestern Nigeria
Authors: Oziegbe E. J. , Oziegbe O.
Published: May 2023

This study presents microstructures from the granite gneiss of the Basement complex of southwestern Nigeria. The granite gneiss of Ikare area comprises of the mineral assemblage; garnet, biotite, K-feldspar, quartz, plagioclase, sillimanite and opaque minerals. K-feldspar porphyroblasts have cuspate interstitial quartz grains, also quartz grains are included in K-feldspar. Most K-feldspar grains are highly strained and in some cases are fractured. Prismatic and fibrolite-type sillimanite are both present. Biotite is closely associated with fibrolitetype sillimanite. Sillimanite was observed to mimic the foliation produced by biotite. K-feldspar is the dominant mineral and could have formed by the dehydration reaction of biotite + plagioclase + quartz + sillimanite → garnet + K-feldspar + melt. Microscopic structures such as strained feldspar grains, micro-fractures in Kfeldspar, simple twinning in K-feldspar, myrmekite, mimicking textures, microperthitic intergrowth and cuspate volumes of quartz surrounding K-feldspar are indicative of melt-bearing and solid-state deformation of regional metamorphic rocks.
Evaluation of two different orally disintegrating tablet formulations containing flurbiprofen inclusion complex and its solid dispersion
Authors: Özyılmaz Emine Dilek , Comoglu Tansel
Published: May 2023

Purpose: To prepare orally dispersible tablet formulations (ODTs) by increasing the solubility of flurbiprofen (FB), which has low water solubility.

Methods: The ODTs were prepared using direct compression method the inclusion complexes and solid dispersions with the highest solubility were further evaluated. Flurbiprofen, polyvinylpyrrolidone (PVP) solid dispersions were blended together by solvent evaporation method, while the inclusion complexes were co-formulated with beta cyclodextrin (β-CD) by kneading at three different ratios. The ODTs were characterized by differential scanning calorimetry (DSC), Fourier transform infra-red spectroscopy (FTIR) and for their micromeritic properties. In addition, the solubility properties of the inclusion complexes and solid dispersions in distilled water were compared with the solubility of flurbiprofen.

Results: The highest solubility value of PVP-FB solid dispersions was found at 1:6 (0.501 mg/mL) and for FB β-CD inclusion complex at 1:2 (0.701 mg/mL). Angle of repose ranged from 28.09 – 32.15 (o); Carr’s index from 7.59 to 10.01; and Hausner’s ration from 1.05 – 1.15. DSC and spectral studies indicate that FB did not chemically interact with either PVP or β-CD.

Conclusion: Orally dispersible tablets containing flurbiprofen β-CD complex exhibit significantly higher bioavailability than the drug alone due to its increased solubility.
Effect of lncRNA pvt1 on HBV replication in HepG2.2.15 cells, and its possible mechanism of action
Authors: Lai Xijie , Gao Guosheng , Jiang Xiunong , Xie Jing
Published: May 2023

Purpose: To investigate the influence of lncRNA pvt1 on hepatitis B virus replication in HepG2.2.15 cells and the underlying mechanism of action.

Methods: Concentrations of lncRNA pvt1 in HBV-positive liver cancer cell lines (HepAD38+, HepG2.2.15+, HepG2+, and HepaRG+), and 3 HBV-negative liver cancer cell lines were determined and compared. Differences in HBV DNA content, levels of HBsAg and HBeAg, and STAT3 axis signal pathway among groups were evaluated.

Results: LncRNA pvt1 levels in HBV-positive hepatoma cells were significantly higher than the corresponding expression levels in HBV-negative hepatoma cells. after si-pvt1 treatment in HepG2.2.15 cells, the 3.2K HBV DNA content increased significantly (p < 0.05), and the expression levels of HBsAg and HBeAg in HepG2.2.15 cells also significantly increased. In all groups, STAT3 protein level was comparable, but p-STAT3 protein expression in si-pvt1 group was significantly reduced, relative to those in Si NC and control groups (p < 0.05).

Conclusion: Levels of lncRNA pvt1 expression in HBV-positive and HBV-negative hepatoma cells differ significantly. Treatment with si-pvt1 decrease HBV DNA content in HepG2.2.15 cells through a mechanism that relates to the STAT3 axis signal pathway. This finding may be beneficial for follow-up treatment of HBV.
Expression of LINC00461 in breast cancer cells and its modulatory effect on miR-607/SLCLA3 axis
Authors: Li Dan , Li Shuangjian , Zhao Qian , Jinsihan Dilixiati , Feng Jinchun
Published: May 2023

Purpose: To investigate the role and mechanisms of action of long non-coding RNA (lncRNA) (LINC00461) in breast cancer.

Methods: Human breast cancer cell lines and normal mammary epithelial cell lines as well as their corresponding negative controls (NC) were cultured and co-transfected with Lipofectamine 3000. Expressions of LINC00461 and miR-607 were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR), while the SLC1A3 level was evaluated by western blot. The role of LINC00461 in cell proliferation, apoptosis, cycle arrest, glycolysis, and chemoresistance was determined by MTT, colony formation, flow cytometry, and ELISA assays.

Results: The LINC00461 level was overexpressed in breast cancer cell lines (p ˂ 0.05). Knockdown of LINC00461 in MCF-7 cells inhibited cell viability (p ˂ 0.01) and the degree of colony formation (p ˂ 0.001), induced cell apoptosis (p ˂ 0.001) and cycle arrest (p ˂ 0.01), and suppressed glucose consumption (p ˂ 0.001), lactate production (p ˂ 0.001), LDHA activity (p ˂ 0.05) and cisplatin sensitivity (p ˂ 0.05). Overexpression of LINC00461 in MDA-MB-468 cells resulted in reverse outcomes. LINC00461 positively regulated the expression of SLC1A3 via miR-607 in breast cancer cells. It was mechanistically established that LINC00461 is bound to miR-607 and miR-607 bound to SLC1A3, and this was confirmed by luciferase assay.

Conclusion: LINC00461 induces cell proliferation, cycle arrest, glycolysis, and chemoresistance by modulating miR-607/SLC1A3 axis in breast cancer. The results lay the theoretical basis for monitoring and therapy of breast cancer.
Safety profile differences between salbutamol and levosalbutamol: Results from the FDA Adverse Event Reporting System
Authors: Peng Wenzhong , Chen Jia , He Ruoxi , Tang Yongjun , Jiang Juan , Ouyang Ling , Zhao Dandan , Li Ying
Published: May 2023

Purpose: To examine the safety profiles of salbutamol and levosalbutamol reported in the Food and Drug Administration Adverse Event Reporting System (FAERS) database.

Methods: Retrospective pharmacovigilance disproportionality analysis for drug-related ADRs reported in the FAERS database was performed from October 1, 2003 to March 31, 2020. The proportion of report ratio (PRR), proportional reporting ratio (PRR), and reporting odds ratio (ROR) were calculated and used for the determination of safety signals. The definition was based on system organ class (SOCs) and Standardized Medical Dictionary for Regulatory Activities Queries (SMQ) by the Medical Dictionary for Regulatory Activities (MedDRA).

Results: A total of 83,166 and 3,133 adverse event reports were identified for albuterol and levalbuterol, respectively, and were linked mainly with 12 SOCs, i.e., cardiac, vascular disorders, respiratory, thoracic, mediastinal disorders, and immune system disorders. The largest ROR among the 20 most frequent SMQs was asthma/bronchospasm for reports both in salbutamol group (ROR: 13.585, 95% CI: 13.254, 13.923) and levosalbutamol group (ROR: 16.225, 95% CI: 14.575, 18.063).

Conclusion: Data mining of the FAERS may be considered a useful approach for identifying salbutamol and levosalbutamol-related adverse events, which might provide additional information to guide their use in clinical practice.
N-methyl-D-aspartate receptor together with complement C5 accelerated chondrocyte apoptosis and inflammation of osteoarthritis via mediating NLRP3
Authors: Lu Wei , Yao Jing , Cheng Yu , Mao Dongmei , Luo Di , Wang Lin
Published: May 2023

Purpose: NMDAR and complements have been reported to facilitate progression of OA but the correlation between NMDAR and complement C5 in OA is unknown. Therefore, NMDAR antagonist, MK801 and C5 inhibitor, eculizumab were applied to measure functions of NMDAR and C5 in SW1353 cells.

Methods: SW1353 cells were first induced with LPS (5 μg/ml and 10 μg/ml) and later 10 μg/ml LPS induced SW1353 cells were treated by MK801 (100 μM) and eculizumab (100μg/ml). Thereafter, NR1, NR2A and C5 RNA expressions were assessed by RT-qPCR in LPS induced SW1353 cells and NR1 with NR2A was measured under MK801 treatment while C5 was analyzed by eculizumab treatment. Later, apoptosis of SW1353 cells were examined through flow cytometry. Inflammatory cytokines TNF-α, IL-6 and NLRP3 RNA expressions were evaluated by RT-qPCR in SW1353 cells from different groups.

Results: NR1, NR2A and C5 RNA expressions were all significantly upregulated after LPS induction with upregulated apoptosis and increased TNF-α, IL-6 and NLRP3. Treatment of MK801, a NMDAR antagonist, reduced NR1 and NR2A levels. Moreover, apoptosis rate of SW1353 and RNA expressions of inflammatory cytokines were all markedly reduced with MK801. Further, eculizumab treatment significantly downregulated C5 RNA expression in LPS induced SW1353 cells. Added eculizumab also enhanced functions of MK801 in repressing apoptosis rate and inflammatory factors RNA expressions.

Conclusion: MK801 and eculizumab suppressed apoptosis and inflammatory response in SW1353 cells through inhibiting NMDAR and complement C5.
Evaluasi Profit dan Kelayakan Finansial Budidaya Pembesaran Ikan Lele Menggunakan Pakan Pelet pada Pokdakan Mina Tanjung Makmur Kabupaten Tulungagung
Authors: Susadiana Susadiana , Fattah Mochammad , Purwanti Pudji , Sofiati Dwi , Anandya Asyifa , Aisyah Diana
Published: May 2023

Ikan lele merupakan ikan konsumsi yang menjadi komoditas utama di Indonesia. Pengembangan teknik budidaya ikan lele digunakan untuk memenuhi kebutuhan pasar. Tujuan dari penelitian ini adalah menganalisis profit dan kelayakan finansial budidaya ikan lele menggunakan pakan pelet. Analisis data dalam penelitian ini menggunakan R/C, BEP, Keuntungan, rentabilitas, NPV, B/C, IRR dan PBP. Budidaya ikan lele pakan pelet menggunakan kolam beton, terpal dan tanah yang dihasilkan dengan tingkat kelulusan hidup sebesar 90%. Usaha budidaya ikan lele dengan pakan pelet dinyatakan profit dan layak karena menghasilkan nilai R/C sebesar 1,40; BEPs sebesar Rp.37.413.242; BEPq sebesar 691 Kg, keuntungan senilai Rp89.505.700; rentabilitas sebesar 40%; NPV senilai Rp225.827.167,31; B/C sebesar 1,81; IRR sebesar 29,6% dan PBP sebesar 3,13. Pembudidaya dapat meningkatkan profit melalui pengembangan teknik budidaya ikan yang paling efisien untuk menghasilkan produksi ikan lele.
Programa Inova Educação no estado de São Paulo (2020)
Authors: Pereira da Silva Rodrigo
Published: May 2023

Este ensaio envolve a mudança na educação paulista a partir do Programa Inova, refletindo a respeito do impacto das ações administrativas na prática docente. O desenvolvimento do texto foi feito através da análise documental, bibliográfica e contribuições pessoais permitidas por minha atuação enquanto docente na educação pública paulista. O programa resultou em alterações na rotina, novas matérias e imputou mais responsabilidade para alunos e professores. Logo, a escola está incorporando metodologias de controle de gestão e fazendo com que as ações de professores e alunos busquem metas estabelecidas que são representadas na nota no Índice de Desenvolvimento da Educação Brasileira (IDEB).
O Ornitorrinco diante da morte
Authors: Henrique Santos Queiroz Pedro
Published: May 2023

O ensaio retoma livremente a metáfora do ornitorrinco elaborada por Francisco de Oliveira, tomando-a como representação do animal político (zoon politikon) brasileiro. A partir do diálogo com a literatura internacional, questiona-se a forma singular com que a questão da mortalidade se coloca para o ornitorrinco diante de duas crises simultâneas representadas pela pandemia de covid-19 (ameaça de morte do corpo biológico - fim da vida como zoé) e de recessão democrática (ameaça de morte do corpo político democrático - fim da vida como biospolitikos).
Uso de Tecnologias de Informação e Comunicação (TIC) na sala de aula dos professores de História de Poções (BA)
Authors: Barbosa Adão Alessandra , Jesus da Silva Edivanda
Published: May 2023

Este relato de pesquisa objetiva discutir a relação entre as Tecnologias de Informação e Comunicação (TICs) e as salas de aulas, com foco nos professores de História da cidade de Poções (BA). A partir de dados levantados com diretores das Escolas Municipais e os respectivos docentes, questionamos: os professores têm habilidade para usar essas Tecnologias? Utilizam com frequência? Como utilizam as TICs no ensino de História? A partir disso e de pesquisa qualitativa, do contato com as políticas públicas de âmbito Federal e de autores como Pierre Lévy (2008), Pedro Demo (2008) e outros, emergem possíveis respostas. Por fim, o relato permitiu perceber o distanciamento entre as políticas públicas e a sala de aula, afetando alunos e professores no processo ensino-aprendizagem.
Assédio sexual no meio universitário: formas de resistência e mobilização
Authors: Gomes Mariana
Published: May 2023

A pesquisa que se segue apresenta a análise bibliográfica a respeito do assédio sexual e suas diversas interpretações, realizando um recorte dentro do meio universitário, buscando uma análise sociológica a respeito das vertentes de assédio existentes na academia, contudo caracterizadas, em sua maioria, pela violência de gênero enfrentada pelas mulheres. A análise central se faz nos casos públicos de assédio de professores contra alunas, considerando a importância da exposição midiática na apuração dos processos. Neste contexto, analisa-se o movimento crescente de grupos de apoio, dada as dificuldades enfrentadas pelas vítimas no que diz respeito a suportes institucionais. Desta forma, reflete-se também sobre o papel dos coletivos feministas como uma fonte de conscientização e apoio às mulheres universitárias, seja no acolhimento das vítimas como na motivação para denúncias e abordagem do tema nos diversos meios de debate.
Sistema de cotas universitárias no Brasil
Authors: Pinheiro da Silva Ana Paula , Rodrigues de Lima Damião Michael
Published: May 2023

Este estudo objetivou analisar os dados do Censo do ensino superior em relação ao acesso ao ensino superior através da lei de cotas (nº 12.711/2012) entre os anos de 2012 a 2018, bem como quantificar os perfis dos cotistas no Brasil. Trata-se de pesquisa quanti-quali, com método indutivo, descritivo e ex-post-facto. A partir da análise dos dados, infere-se que os perfis dos cotistas (autodeclarados) segundo a cor/raça, gênero e sexualidade em Instituições Federais de Ensino, por ordem de relevância, são: negros, brancos, amarelos, a comunidade de trans e indígenas. Salienta-se que a educação teve inúmeros retrocessos, provavelmente por ser gerida por políticos sem qualquer vínculo com as práticas pedagógicas nem com seus princípios de emancipação, mas que, ainda assim, interferem na matriz curricular.
“We’re kind of forgotten about really”: An exploration into the impact of Covid-19 lockdown restrictions on unpaid carers of individuals with disabilities.
Authors:   , Gass Amy
Published: May 2023

This research project aimed to identify how the Covid-19 lockdown restrictions in the UK impacted unpaid carers of individuals with disabilities. This was achieved through the application of a social constructionism methodological framework aided by the adoption of standpoint epistemology to prioritise the voices of the oppressed- the unpaid carers. The data was collected using an embedded mixed-method approach employing semi-structured interviews and online questionnaires, with a total of 18 participants. The qualitative findings from both research methods were analysed using thematic analysis. The findings from this research concluded that the lives and routines of unpaid carers have been negatively impacted by the Covid lockdown restrictions due to a variety of reasons such as changes in routines causing behavioural problems for the individual they care for. The restrictions also caused issues with activities such as shopping and attempting to adhere to the lockdown regulations whilst being a primary carer. The findings highlighted how issues already faced by unpaid carers were exacerbated in the pandemic, including their financial struggles. However, the findings of this research also concluded that there were positive outcomes of the lockdown which included more time to spend with family. Furthermore, the findings helped examine carers’ views on vulnerability and what it meant to be ‘vulnerable’. It was concluded that the term is not inclusive and ignores the unpaid carers’ inflicted vulnerabilities brought about due to their caring responsibilities. The debates surrounding vulnerability aided the discussion on carers views of inclusivity and it was apparent that more needs to be achieved in order to create a more inclusive society.
Đặc điểm lâm sàng, cận lâm sàng và giai đoạn ung thư tế bào mầm buồng trứng tại Bệnh viện Phụ sản Trung ương
Authors: Phạm Trí Hiếu , Nguyễn Quốc Tuấn , Vũ Bá Quyết
Published: May 2023

Đặt vấn đề: Ung thư tế bào mầm buồng trứng (UTTBMBT) là một trong ba thể mô bệnh học chính của ung thư buồng trứng (UTBT) có nhiều đặc điểm khác biệt. Mục tiêu: mô tả đặc điểm lâm sàng, cận lâm sàng và giai đoạn UTTBMBT tại Bệnh viện Phụ sản Trung ương (BVPSTƯ).

Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả hồi cứu. Tất cả các bệnh nhân được chẩn đoán mới mắc UTTBMBT nguyên phát, được phẫu thuật tại BVPSTƯ, điều trị từ tháng 1/2015 đến hết tháng 12/2020.

Kết quả: Có tổng số 92 bệnh nhân từ 6 đến 58 tuổi, độ tuổi trung bình: 22,9 ± 8,6; 82,6% dưới 30 tuổi. Triệu chứng thường gặp nhất là đau bụng âm ỉ (37%); 93,8% đi khám trong vòng 1 tháng. Trên chẩn đoán hình ảnh, khối u có kích thước lớn (83,7% khối u > 10 cm) và có tổ chức đặc (94,6%). Thể giải phẫu bệnh phổ biến nhất là u quái (55,4%) bao gồm u quái không trưởng thành và u quái trưởng thành chuyển dạng ác tính. Hầu hết bệnh nhân UTTBMBT được chẩn đoán ở giai đoạn I theo FIGO (95,6%).

Kết luận: UTTBMBT thường gặp ở phụ nữ trẻ tuổi, phát triển nhanh, u kích thước lớn, có tổ chức đặc, chẩn đoán được ở giai đoạn sớm, từ đó có kết quả điều trị khả quan.
Tổng quan về điều trị testosterone cho phụ nữ
Authors: Hê Thanh Nhã Yến , Triệu Thị Thanh Tuyền , Ngô Việt Thảo
Published: May 2023

Việc điều trị testosterone cho phụ nữ được áp dụng khá rộng rãi, với nhiều chỉ định khác nhau. Dù vậy, đến nay vẫn chưa có cơ quan quản lý dược nào phê duyệt chế phẩm testosterone chính thức cho phụ nữ. Chứng cứ về tính an toàn của sử dụng testosterone lâu dài cũng chưa đầy đủ. Bài viết cập nhật những khuyến cáo mới nhất của các hiệp hội chuyên ngành về chỉ định, phương thức và theo dõi điều trị testosterone dựa trên y học chứng cứ nhằm định hướng cho thực hành lâm sàng.
Nghiên cứu tình hình mổ lấy thai ở sản phụ sinh con so tại Bệnh viện Sản - Nhi tỉnh Quảng Ngãi
Authors: Nguyễn Xuân Minh , Trương Quang Vinh
Published: May 2023

Mục tiêu: 1. Khảo sát tỷ lệ và chỉ định mổ lấy thai ở sản phụ sinh con so tại Bệnh viện Sản Nhi tỉnh Quảng Ngãi. 2. Đánh giá kết quả mổ lấy thai và một số yếu tố liên quan ở sản phụ sinh con so.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên sản phụ mang thai con so kết thúc thai kỳ tại khoa Sản, Bệnh viện Sản Nhi tỉnh Quảng Ngãi từ 10/2020 đến 06/2021.

Kết quả: Có 917/2.035 trường hợp mang thai con so được MLT, chiếm 45,1%. Nguyên nhân thường gặp nhất lần lượt là do đường sinh dục (53,9%), do thai hoặc ngôi thai (43,2%), do phần phụ (34,6%), do mẹ (16,0%). Nguyên nhân đường sinh dục hay gặp là CTC không tiến triển (30,6%) và điểm Bishop thấp (23,1%). Nguyên nhân do phần phụ hàng đầu là ối vỡ non/ối vỡ sớm, chiếm (74,2%) tiếp theo là thiểu ối/cạn ối (20,4%). Suy thai là nguyên nhân do thai hay gặp nhất với 61,9%, tiếp đến là thai to (13,1%) và ngôi bất thường (18,6%). Chỉ định MLT do mẹ hay gặp là TSG-SG (28,6%), con quý hiếm (27,9%) và mẹ vị thành niên (17,0%). Phương pháp phẫu thuật: 100% sản phụ được rạch ngang đoạn dưới tử cung lấy thai; phương pháp vô cảm chủ yếu là tê tủy sống (93,7%). Kết quả MLT: tỷ lệ biến chứng trong và sau mổ rất thấp (0,9% và 1,2%); biến chứng gặp trong mổ gồm chảy máu 0,5%, đờ tử cung 0,3% và khối máu tụ 0,1%; biến chứng sau mổ gồm nhiễm trùng thành bụng 0,5%, đờ tử cung 0,4%, liệt ruột 0,2% và tụ máu thành bụng 0,1%; điểm Apgar 1 phút và 5 phút sau sinh < 7 điểm chiếm tỷ lệ rất thấp; hầu hết sinh đủ tháng (95,0%), trẻ có dị tật bẩm sinh chỉ chiếm 0,8%; thời gian hậu phẫu hầu hết ≤ 7 ngày (97,4%); tỷ lệ nằm viện sau mổ > 7 ngày cao hơn ở nhóm có biến chứng trong hoặc sau mổ (p<0,05); không có sự khác biệt về tỷ lệ nằm viện sau mổ > 7 ngày giữa các phương pháp vô cảm, tuổi thai, trọng lượng thai và kỹ thuật MLT (p>0,05).

Kết luận: MLT ở sản phụ sinh con so có chỉ định phù hợp là an toàn và giúp cải thiện tiên lượng của mẹ và trẻ sơ sinh.
Đánh giá kết quả điều trị bệnh rối loạn tĩnh mạch tiểu khung bằng can thiệp nội mạch
Authors: Phan Hoàng Giang , Trương Hồng Đức , Trần Văn Giang , Nguyễn Xuân Hiền , Vũ Đăng Lưu
Published: May 2023

Đại cương: Bệnh lý rối loạn tĩnh mạch tiểu khung chiếm 10% nguyên nhân gây đau vùng tiểu khung, thường xảy ra sau đẻ. Triệu chứng đau khi giao hợp, đứng lâu, có kinh trên 6 tháng mà loại trừ các nguyên nhân vùng tiểu khung. Phương pháp hiện tại chủ yếu là giảm đau. Can thiệp nội mạch là phương pháp chủ yếu được sử dụng điều trị bệnh lý này. Mục tiêu: Đánh giá hiệu quả lâm sàng và tính an toàn của can thiệp nội mạch trong điều trị bệnh lý rối loạn tĩnh mạch tiểu khung có triệu chứng đau.

Đối tượng và phương pháp: Chúng tôi đã thực hiện gây tắc tĩnh mạch buồng trứng ở 15 bệnh nhân (tuổi trung bình, 37,8 tuổi; độ tuổi 30-58) tại Trung tâm Điện Quang, Bệnh viện Bạch Mai từ tháng 1 năm 2019 đến tháng 1 năm 2022. Trong đó 14 bệnh nhân bằng nút tắc mạch thực hiện bằng keo sinh học hisatocryl và coils, 1 bệnh nhân được gây tắc bằng dù và spongel. Bệnh nhân được đánh giá các thông số trước và sau điều trị 1, 6, 12 tháng: đánh giá triệu chứng đau, mức độ giãn của mạch máu tiểu khung trên siêu âm, MSCT, MRI (chụp thời điểm sau can thiệp 6 tháng).

Kết quả: Tỷ lệ thành công kỹ thuật là 100%, theo dõi lâm sàng cho thấy giảm triệu chứng đau trong 14 bệnh nhân (chiếm 94%). Có 01 bệnh nhân triệu chứng giảm ít cần tiếp tục điều trị nội khoa. Không có biến chứng chính sau can thiệp.

Kết luận: Can thiệp nội mạch là phương pháp an toàn, hiệu quả điều trị giảm đau trong bệnh lý rối loạn tĩnh mạch tiểu khung.
Tỷ lệ tổn thương tầng sinh môn của phương pháp giữ tầng sinh môn trong sinh ngả âm đạo tại Bệnh viện Hùng Vương năm 2021
Authors: Hoàng Thị Thùy Trang , Hoàng Thị Huệ , Nguyễn Ngọc Bảo Hân , Tạ Ngọc Phương Trinh , Cao Thị Ngọc Bích , Cù Thị Vĩnh Phát , Đoàn Ngọc Phương Quỳnh
Published: May 2023

Đặt vấn đề: Sinh thường có thể gây rách âm đạo và các mô xung quanh âm đạo, thường xuất hiện khi đầu của em bé được sinh ra. Một số trường những vết rách có thể kéo dài đến trực tràng và mất nhiều thời gian để phục hồi vết thương. Để tránh những vết rách sâu, các bác sĩ đã khuyến cáo nên giữ tầng sinh môn (TSM) trước và trong khi sổ đầu thai nhi (chỉ cắt tầng sinh môn có chọn lọc) để tránh bị rách nặng và tạo điều kiện thuận lợi cho việc sinh nở.

Mục tiêu nghiên cứu: Xác định tỷ lệ và các mức độ tổn thương tầng sinh môn; các yếu tố liên quan đến tỷ lệ tổn thương tầng sinh môn và những kết cục của mẹ và bé liên quan đến phương pháp giữ tầng sinh môn trong sinh ngả âm đạo.

Phương pháp nghiên cứu: Nghiên cứu cắt ngang thu thập dữ liệu trên 367 sản phụ được giữ tầng sinh môn sinh ngả âm đạo tại Bệnh viện Hùng Vương từ tháng 04 năm 2021 đến tháng 06 năm 2021.

Kết quả nghiên cứu: Tỷ lệ tổn thương TSM sau sinh là 77,9%; con so (40/47) chiếm tỷ lệ 85,1%; con rạ (246/320) chiếm tỷ lệ 76,9%, phần lớn TSM tổn thương ở mức độ 1 chiếm tỷ lệ 93,7%; 6,3 % tổn thương TSM độ 2; không có trường hợp nào có tổn thương TSM độ 3 và độ 4. Các yếu tố liên quan đến tổn thương TSM là BMI, tuổi thai và cân nặng trẻ lúc sinh với p<0,05. Tỷ lệ sản phụ điều trị bởi kháng sinh dự phòng nhiễm khuẩn TSM là 1,4%; 0,85% sản phụ bị sưng TSM; 100% sản phụ không có khối máu tụ sau may phục hồi TSM. Bé sau sinh được theo mẹ chiếm tỷ lệ 93,2%.

Kết luận: Phương pháp giữ TSM trong các ca sinh ngả âm đạo đã mang lại lợi ích cho rất lớn cho bà mẹ khi sinh ngả âm đạo, giảm thiểu tổn thương TSM độ 2, cũng như độ 3, độ 4 và không gây kết cục xấu cho trẻ sau sinh.
Economic Globalization and Income Inequality: A Review
Authors: Hui Yan , Bhaumik Amiya
Published: May 2023

The potential for economic progress has been constrained in recent decades by growing income disparity. Using panel data methodologies and policy simulations, this study examines the impact of economic globalisation on income inequality in both a cross-country and country-specific context. The sample includes post-liberalization developed, developing, and least-developed nations. The findings reveal that globalisation has reduced inequality in advanced nations while having the reverse impact in low-income ones. Trade and FDI have opposing effects on income distribution; trade makes it worse, but FDI is good for all countries and helps to lessen income inequality. It has been discovered that FDI has a greater effect on lowering income disparity. The effects of economic globalisation on income inequality globally have been examined in a sizable body of econometric work. It is difficult to draw reliable conclusions because stated econometric estimates vary greatly. The link between globalisation and inequality is summarised quantitatively and analysed in this work. Researchers utilise a fresh dataset comprised of 1,254 observations from 123 original studies. Using meta-analysis and meta-regression methods, researchers reach a number of important results. First, there is a small to moderate increase in inequality as a result of globalisation. Second, whereas the impact of trade globalisation is negligible, the impact of financial globalisation on inequality is much larger and substantially stronger. Third, both developed and developing nations see an average increase in inequality as a result of globalisation. Fourth, technology and education mitigate the effects of globalisation on economic disparity.
Effect of Combined Use of social media, Digital, and Traditional Communication Tools in the Business-to-Business Sales Process of Multinational Small and Medium-sized Enterprises (SMEs)
Authors: Licong Hu , Ghosh Abhijit
Published: May 2023

Social media and digital networks have gradually changed how firms sell themselves. In a world where technology is permeating society more and more, understanding how sales teams use business-to-business (B2B) markets can provide insight into the motivations driving the selling process. In the three crucial stages of the B2B sales process, this study investigates how global SMEs use traditional, digital, and social media sales communication methods. The paper's use of grounded theory shows how social media may be quite effective in luring clients from outside. The effective phase appears to be where digital communication tools are most common, whereas customer relationship management still favours more conventional communication methods. Nevertheless, certain important potential boundary circumstances, like relationship culture and closeness to a location, technology, the strategic value of the consumer, creativity, and capital, appear to have an impact on how international SMEs employ a range of communication channels when conducting business. To assist foreign SMEs with their sales communication, designers provide a method for understanding the flow of the B2B sales process.
The Potential for Major Corporations to Achieve Success through Entrepreneurship, Expanding Beyond the Conventional Focus on Startups
Authors: Liping Qin , Zefeng Chen
Published: May 2023

The strategy of the Innovation Management System encompasses inter-company procedures and activities such as networking, management, marketing, and so on. The goal of this study is to provide instances of how knowledge creation works in these settings. This article is a qualitative survey that addresses how to apply open innovation techniques in Norwegian IT companies in order to obtain access to fresh business ideas. This research strives to increase awareness of the earlier question and provide guidance for future studies through the examination and evaluation of applicable literature. This improved grasp of how to use innovation management tactics would benefit both businessmen and authorities participating in proposal appraisal. This research focuses on the adoption of strategies by small businesses and startups, both of which are relatively unexplored areas for research. It offers suggestions for reality-based thinking, social media participation, and prepared versus haphazard tactics. Based on an in-depth questionnaire with four anonymous Norwegian digital samples, this empirical research article forms a study. This study lays out a clear strategy for analyzing the openness of invention and networked theories described in the objectives. Contrary to earlier studies, this article will expose gaps and common problems created by start-ups rather than create seamless entrepreneurial tactics for the benefit of their organization. Following the final discussions with start-ups, the findings were coupled with library evaluations and associated theories, as well as empirical facts, to support the presented query. Finally, the findings are classified and categorized in the list below based on interviewer responses.
Distributional Impacts of Recessions: The COVID-19 Epidemic Recession and the Global Financial Crisis
Authors: Siliang Lai , Bhaumik Amiya
Published: May 2023

This study helps us understand the similarities and differences between the distributional impacts of the COVID-19 pandemic and the Global Financial Crisis by breaking them down into four categories: (i) worker characteristics; (ii) job characteristics; and (iii) flexible/work-from-home jobs and essential jobs, which were exempt from government-mandated shutdowns during this recession. In the past, recessions have hurt younger and less educated workers more, but the Pandemic Recession hit women and people of Hispanic heritage especially hard. Jobs that require a certain amount of adaptability, social interaction, and a need seem to be less affected by changes in the economy. The non-cyclical character of this employment has historically been caused by the rising share of skilled people in highly adaptable occupations. When the Pandemic Crisis hit, however, it was the flexible and crucial occupations that were hit most, rather than the social service sector. Both recessions have had a significant distributional effect, since low-income people have been hit more than high-income ones. Finally, in contrast to the Great Crisis of 2008–2009, many people who lost their jobs during the COVID-19 recession were only out of work temporarily.
Analisis Quality of Service (QoS) Jaringan Internet Universitas Menggunakan Metode Hierarchical Token Bucket (HTB)
Authors: Valia Yoga Pudya Ardhana  , Mulyodiputro M. Dermawan
Published: May 2023

Qamarul Huda Badaruddin University is a private university located in Central Lombok Regency with an increasing number of students. Along with the increasing number of students, of course, the number of internet users on campus also increases, making traffic on the network more complex and requiring network management. Quality of Service (QoS) can be regarded as a terminology used to define the characteristics of a network service (Service) to find out how good the quality is in that service. With Quality of Service (QoS), bandwidth can be used optimally so as to improve the quality of internet services received by users. The application of appropriate bandwidth management needs to be done, one of which is using the HTB method, namely bandwidth management with bandwidth borrowing queuing techniques between classes or users. Which can allocate bandwidth according to the user's bandwidth requirements in accordance with the specified priority. The purpose of this study is to determine the Quality of Service (QoS) produced by the HTB method in conducting bandwidth management so as to improve existing internet services at Qamarul Huda Badaruddin University. The results of the Quality of Service (QoS) analysis based on the tests that have been carried out show that by applying the Hierarchical Token Bucket (HTB) method, satisfactory results are obtained, namely a value of 3.67. These results are obtained from the average test results on 4 parameters, namely delay, jitter, packet loss, and throughput.
Employing Podcast Technology in Developing English Pronunciation: A Quasi-Experimental Study
Authors:   The Arab Academic College of Education, Alobeytha Faisal Lafee , Ghalia Nadia Hassan ,   The Arab Academic College of Education, Galia Ali Ahmad ,   Ministry of education- Jordan, Bani Khaled Shamsa Ali ,   Ministry of education- Jordan
Published: May 2023

This study looked at the impact of podcast technology on the development of English listening skills. It used a mixed method (qualitative and quantitative methods). A quasi-experimental technique with a post-course test was adopted. Two teachers were interviewed in a semi-structured format. The sample for the study was 52 fifth-grade students at a private school in Amman, Jordan. They were divided into two classes (26 students for the experimental class and 26 for the control class). The experimental class was taught listening via teacher and podcast, while the control class was taught listening via teacher alone. To collect data, a multiple-choice test, survey, and interview were carried out. To analyze data, SPSS was used to analyze quantitative data, and Braun and Clark's thematic approach was used to analyze qualitative data. The findings of the study were that (i) the effect of employing podcast technology on improving listening skills is obvious and (ii) the superiority of the experimental class over the control class is large. (iii) the possibility of using podcast technology in the development of listening skills, increasing the student's bank of vocabulary, and improving their pronunciation.
Relationship between Self-Efficacy, Organizational Climate, Work Commitment and Organizational Citizenship Behavior (OCB) of Public Junior High School Teachers in North Banjarmasin District
Authors:   Master in Educational Administration, Lambung Mangkurat University, Banjarmasin, Indonesia, Ristinah Nira , Effendi Rustam ,   Master in Educational Administration, Lambung Mangkurat University, Banjarmasin, Indonesia, Sulaiman Sulaiman ,   Master in Educational Administration, Lambung Mangkurat University, Banjarmasin, Indonesia
Published: May 2023

The purpose of this study is to analyze the direct and indirect relationship between Self-Efficacy, Organizational Climate, Work Commitment and Organizational Citizenship Behavior (OCB) of SMPN teachers in North Banjarmasin District. The research design used in this study is descriptive correlational using a path analysis model to analyze the pattern of relationships between variables. The study population was 273 teachers from 10 junior high schools in North Banjarmasin District, Banjarmasin City, and 163 respondents were taken as research samples using the Probability Simple Random Sampling technique. Data collection using questionnaire instruments and data analysis using descriptive analysis, classical assumption testing, hypothesis testing and path analysis. The results of the analysis of the regression coefficient of the variables Self Efficacy and Organizational Citizenship Behavior (OCB) amounted to 0.276, the variables of Organizational Climate and Organizational Citizenship Behavior (OCB) amounted to 0.332, the variables of work commitment and Organizational Citizenship Behavior (OCB) amounted to 0.311, the variables of Self Efficacy and Work Commitment amounted to 0.442, the variables of Organizational Climate and teacher work commitment amounted to 0.544, variables of Self Efficacy and Organizational Citizenship Behavior (OCB) through work commitment of 0.137 and variables of Organizational Climate and Organizational Citizenship Behavior (OCB) through a commitment of 0.169. The conclusion of this study is that the variables of Self-Efficacy, Organizational Climate, Work Commitment and Organizational Citizenship Behavior (OCB) of SMPN teachers in North Banjarmasin District are all included in the high category. There is a partial direct relationship between Self Efficacy, Organizational Climate, Work Commitment and Organizational Citizenship Behavior (OCB) of SMPN teachers in North Banjarmasin District. There is an indirect relationship between Self Efficacy, Organizational Climate and Organizational Citizenship Behavior (OCB) through work commitment at SMPN North Banjarmasin District, Banajrmasin City. Suggestions for an increase in self-efficacy variables still need to be improved in organizational climate variables, work commitment and Organizational Citizenship Behavior (OCB).
Dose de fitase e efeito extra fosfórico em dietas para leitões
Authors:   , Assoni Pedro Esperidião
Published: May 2023

Um total de 1.000 leitões (9,80 ± 0,07 kg) foram usados em um estudo para avaliar os efeitos dos níveis de fitase na dieta sobre o desempenho de crescimento de 40 a 70 dias de idade, alimentados com uma dieta com limitação de fósforo, cálcio, aminoácidos e energia. Cinco tratamentos foram distribuídos em delineamento em blocos ao acaso com base no peso corporal (PC), com oito repetições de 25 suínos por unidade experimental. Os tratamentos consistiram de: dieta controle positivo (CP), dieta controle negativo (CN), e dietas CN suplementadas com 750, 1.375 e 2.000 FTU Quantum Blue 10 G fitase/kg. As dietas CN foram formuladas com redução de fósforo, cálcio, aminoácidos e energia. Ração e água foram fornecidas ad libitum durante todo o experimento. Foram avaliados os efeitos dos tratamentos sobre o peso corporal final (PC final), consumo diário de ração (CDR), ganho diário de peso (GDP) e taxa de conversão alimentar (CA). Diferenças nos parâmetros de desempenho dos leitões foram observadas entre leitões alimentados com dietas CP vs. CN. O PC final dos leitões, o CDR e o GDP aumentaram (linear, P < 0,05 e quadrático, P < 0,05) com o aumento da dose de fitase. A suplementação de fitase reduziu (linear, P < 0,05 e quadrático P < 0,05) a CA. As doses ótimas de fitase para PC final, CDR, GDP e CA foram 1.222, 1.000, 1.272 e 1.309 FTU/kg, respectivamente. Em conclusão, a suplementação de fitase em doses entre 750 e 2.000 FTU/kg permite a redução dos níveis nutricionais de fósforo, cálcio, aminoácidos e energia, sem prejudicar o desempenho dos leitões entre 40 e 70 dias de idade. Palavras-chave: Fitase. Superdosagem de fitase. Efeitos extra fosfóricos. Nutrição. Suínos.
Indicadores zootécnicos e econômicos na recria e terminação de bovinos de corte na região noroeste do estado de Minas Gerais
Authors:   , Assunção Rafael Neiva
Published: May 2023

Objetivou-se, com este estudo, avaliar a viabilidade da suplementação durante a recria e o uso do confinamento ou TIP para redução do ciclo de produção na fazenda, aumento o giro de animais e consequentemente a rentabilidade, em fazenda localizada no município de Unaí, na região noroeste do estado de Minas Gerais. Foram avaliados 300 animais, todos nascidos na própria fazenda. Sendo 100 animais avaliados no ano de 2017, 100 animais avaliados em 2018 e 100 animais avaliados no ano de 2019. Todos os animais foram pesados à desmama, recriados em pastagem irrigada com sistema de pivô central. Em 2017, a suplementação utilizada foi proteico-energética, com consumo estimado de 3 gr/kg do peso corporal. No ano de 2018, utilizou-se suplementação proteico-energética, com consumo de 8 gr/kg do peso corporal. E, em 2019, foi utilizado concentrado, com consumo médio de 10 gr/kg do peso corporal. O nível de suplementação influenciou o custo de produção e, também, o ganho médio diário. Na fase de terminação, nos anos de 2017 e 2018, optou-se pelo confinamento e, em 2019, foi feita a TIP. Na TIP, não foi necessário grande estoque de volumoso para a terminação e a mão-de-obra foi menor do que a utilizada no confinamento. O ano de 2019 foi marcado pelo início da grande valorização no preço de venda da arroba, devido à alta demanda por carne e à baixa oferta de animais terminados. Isso influenciou na maior margem de lucro obtida no ano de 2019, 94,09%, ao final do ciclo de produção de 16 meses. O estudo mostrou que é viável intensificar a produção de bovinos de corte, o aumento na suplementação dos animais com o uso da TIP aumentou a margem de lucro da propriedade. Palavras-chave: Indicadores. Recria. Terminação. Lucro.
Precipitation of Iron Carbides in Heterogeneously Shaped Steel with Widmanstätten Structure
Authors:   Department of Materials and Chemicals Engineering. Faculty of Chemistry, Complutense University of Madrid, Spain (U.C.M.), Garcia Laura , Queiros Growene W ,   Rovuma University, Nampula, Mozambique, Meseguer-Sanchez J. Victor ,   Department of Materials and Chemicals Engineering. Faculty of Chemistry, Complutense University of Madrid, Spain (U.C.M.), Salazar Jose Mª Gomez de ,   Department of Materials and Chemicals Engineering. Faculty of Chemistry, Complutense University of Madrid, Spain (U.C.M.), Criado Antonio J ,   Department of Materials and Chemicals Engineering. Faculty of Chemistry, Complutense University of Madrid, Spain (U.C.M.)
Published: May 2023

We have been able to obtain by means of scanning electron microscopy, structural morphologies of iron carbide that being so singular become a definitive witness of the existence or not of incineration in the archaeological pieces of steel that present them. They present a very peculiar image, which proves their origin.
COMPENSATION TOOLS AND EMPLOYEE PERFORMANCE IN NIGERIAN: A SELECTED STUDY OF MINISTRY OF YOUTH AND SPORTS, EDO STATE
Authors: O. Cletus Owuze , Akhimien Prince Godswill
Published: May 2023

Since compensation is the organization’s lifeblood, compensation management plays a crucial and valuable function in human resource management. Moreover, it is crucial for both employees and employers This study focuses on Compensation Tools and Employee Performance in the Ministry of Youth and Sports in the state of Edo. The particular objective for this study is to determine the impact of health insurance on service quality. From the study objective, a hypothesis was stated, and 176 respondents at the Ministry of Youth and Sports of Edo state completed the self-administered questionnaires to measure the relationship between the variables. Pearson Product Moment Correlation Analysis was used to analyze the gathered data. Based on the results gathered, there is a strong positive correlation between health plans and service quality in the Ministry of Youth and Sports of Edo state. The study concluded, based on the findings, that employee performance is directly affected by salary. Accordingly, it was suggested that adequate health benefits and Service Quality should be included in a remuneration package that influences the performance of employees.
TESTING THE WEAK FORM OF EFFICIENT MARKET HYPOTHESIS IN DEVELOPING COUNTRIES (LDCS) STOCK MARKETS: LIMITS AND SUGGESTIONS
Authors: Omer Kouakou Thiéjé Gaudens
Published: May 2023

This paper highlights some limits of weak form of efficiency tests on stock markets in developing countries. These tests, by neglecting important questions such as joined tests and the “bad model problem”, don't integrate all the empirical implications of the informational efficiency theory. By using a framework inspiring from Fama (1970) sub-martingale model and the Harrison-Kreps (1981) paradigm, we show the relevance of joined tests using as underlying model an equilibrium model as DCAPM (downside-Capital Asset Pricing Model) compatible with asymmetry and non-normality of the distribution of returns indeveloping countries.
IMPACT OF INTERNATIONAL TRADE ON ECONOMIC GROWTH: THE GRANGER CAUSALITY TEST APPROACH
Authors: Magaji Sule , Abubakar Mansur Mohammed
Published: May 2023

The study analyzes the impact of international trade on economic growth in Nigeria. Using Granger Causality test it indicates that trade balance does not Granger cause real gross domestic product at 5% level of significance. It also indicates that the degree of trade openness does not Granger cause real gross domestic product at 5% level of significance. The regression result shows that trade is not statistically significant to economic growth. Also, the result shows that trade openness is not statistically significant to economic growth. It is recommended that there is need for effective foreign exchange management capable of ensuring optimal productivity in the critical sectors of the economy. This can be achieved by diversification of the economy away from oil with a view to expanding export of non-oil goods and services to strengthen naira exchange rate under the managed float regime.