bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Techniques for the Detection of Ploidy Level and Genetic Fidelity of Regenerated Plantlets
Authors: Rohela Gulab Khan , Saini Pawan
Published: September 2023

Most of the medicinal, aromatic and other commercially important crops are
poor rooters, and some of them are sessile in terms of seed production; hence these
plants are very difficult to propagate either through stem cuttings based vegetative
propagation or through seedlings based sexual propagation. During the last two
decades, plant tissue culture has emerged as an alternative technique for the
propagation of plants with commercial importance. Majorly, the somatic tissues, viz.,
leaf, node and shoot tip, are being used as explants for the production of genetically
similar plantlets through tissue culture studies. Recently, abnormalities with respect to
ploidy level and genetic fidelity have been reported in In Vitro regenerated plantlets.
This is mainly due to the usage of synthetic chemicals or artificial plant growth
regulators in In Vitro culture studies, the fragile nature of callus and exposure of
cultures to artificial light sources. In order to ensure the commercial production of
genetically true clones of commercial plants, nowadays it has become an obligatory
step to assess the ploidy level and genetic fidelity of regenerated plantlets with that of
mother plants. This book chapter focussed on different molecular techniques which are
in use for the detection of ploidy level and genetic fidelity of In Vitro micro propagated
plantlets.
TÜRKİYE’DE OTUZUNCU YILINDA AİLE HEKİMLİĞİ ANABİLİM DALLARI VE AKADEMİK KADROLARIN NİCEL İNCELENMESİ
Authors: ERDEM Özgür , YOSUNKAYA Ahmet , ERDEM Ali
Published: September 2023

Amaç: Bu çalışma Türkiye’de bulunan aile hekimliği anabilim dalları, öğretim üyesi, uzmanlık öğrencisi ve uzman sayılarının nicel olarak incelenmesi amacıyla yapılmıştır.
Yöntem: Kesitsel tanımlayıcı tipteki bu çalışmada Türkiye’de bulunan üçüncü basamak aile hekimliği klinikleri ve anabilim dalları incelendi. Aile hekimliğindeki mevcut öğretim üyesi sayısı, asistan sayısı ve varsa yetiştirdikleri uzman hekim sayıları araştırıldı. Türkiye’deki her aile hekimliği kliniği veya anabilim dalına Mart-Nisan 2022 tarihlerinde telefon, e-mail veya WhatsApp uygulaması üzerinden ulaşılarak anabilim dalları /klinikler ile ilgili veriler toplandı.
Bulgular: Araştırmamızda 105 tane üçüncü basamak aile hekimliği kliniği veya anabilim dalının mevcut olduğu tespit edildi. Türkiye’deki bu 105 aile hekimliği kliniğinde çalışan öğretim üyesi sayısını incelediğimizde 104 doktor öğretim üyesi, 86 doçent ve 74 profesör olduğu saptandı. Türkiye’de şu ana kadar 211 kişinin doçentlik sürecini tamamlayarak Yüksek Öğretim Kurumundan aile hekimliği alanında “doçent unvanı” aldığı tespit edildi. 211 kişiden 93’ünün profesörlük kadrosuna atandığı saptandı. Halen Türkiye’de 3727 Aile hekimliği asistanı ve 4107 aile hekimliği uzmanı olduğu saptandı
Sonuç: Türkiye’de ilk anabilim dalının kurulmasından bugüne kadar geçen yaklaşık 30 yıllık zaman zarfında bir tıpta uzmanlık alanı olarak tanınan aile hekimliğinin; nicel ve nitel gelişiminde iyi bir ivme kazandığı görülmektedir. Diğer taraftan artan asistan ve anabilim dalı sayısına göre öğretim elemanı sayısının geride kaldığı saptandı. Bu durumun eğitim kalitesinde gerilemeye neden olmaması için yeni akademisyenlerin yetişmesine öncülük edilmelidir.
POLÍTICAS PÚBLICAS E ESTRUTURA ESTATAL NO ATENDIMENTO DO ADOLESCENTE EM CONFLITO COM A LEI E PORTADOR DE TRANSTORNO MENTAL
Authors: Filho Esmar Custódio Vencio , Machado Bruno Amaral
Published: September 2023

O objetivo do artigo é analisar as políticas públicas instituídas para o atendimento ao adolescente em conflito com a lei e portador de transtorno mental. Como hipótese inicial, argumenta-se que o direito positivado é central para a vocalização de demandas relacionadas à concretização de direitos fundamentais por meio de políticas públicas. O sistema infanto-juvenil foi instituído como aparato constitucional centralizador das medidas voltadas ao atendimento desse público. Nesse âmbito, a ausência de regramento legal específico para o atendimento dos adolescentes em conflito com a lei portadores de transtornos mentais merece atenção dos pesquisadores no campo. Embora o Estatuto da Criança e do Adolescente (ECA) e a Lei 12.594/2012 (SINASE) tenham avançado bastante na cobertura normativa em relação à infância e juventude, neste particular (adolescente em conflito com a lei e portador de transtorno mental), não há previsão legal de estrutura e formas de atendimentos. A lacuna identificada é objeto de debates e projetos de lei no Legislativo Federal, porém com muita resistência e embates por entidades e organizações não governamentais, organismos públicos (Ministérios Públicos Estaduais e Federal – MPE e MPF, Defensorias Públicas – DP etc.), Ordem dos Advogados entre outros. A partir dessa hipótese, indaga-se: quais são os projetos de lei em relação ao tema? Diante da lacuna legal, quais são os arranjos construídos pelos atores envolvidos para atender os adolescentes em conflito com a lei que padecem de enfermidades psíquicas?
ENSINO, REALIDADE E METAVERSO NO DIREITO ADMINISTRATIVO
Authors: Arruda Câmara Jacintho
Published: September 2023

Este artigo exprime o depoimento do autor sobre as mudanças percebidas no direito administrativo brasileiro ao longo de três décadas de vivência. Ele é baseado no relato pessoal das fases como estudante de graduação e pós-graduação na disciplina de direito administrativo, e dos desafios – passados e atuais – que enfrentou e enfrenta como professor da disciplina.
Quantifying the Prevalence of Acute Vestibular Neuritis through Big Data Analysis
Authors: Yoon Chul Young , Hong Seulgi , Park Ji-Yun , Seo Young Joon
Published: September 2023

Objectives: Big data analytics in healthcare research have gained momentum, offering unprecedented opportunities to investigate complex medical conditions like acute vestibular neuritis (AVN). However, an inappropriate definition can introduce bias and inaccuracies into prevalence estimation, making the results unreliable and hindering cross-study comparisons. The Health Insurance data in South Korea will be used to create a robust operational definition for AVN.Methods: The study utilized the National Patients Sample dataset from the Health Insurance Review and Assessment Service (HIRA) of the Republic of Korea. The operational definition of AVN was defined using the HIRA data, which includes specific codes for diagnosis, testing, and medications. The revised categorization scheme for AVN was presented as case 1 through case 5, with criteria for each category.Results: The optimal conditions are deemed to be those that encompass the outcomes of both case 5 and case 1-1, encompassing all conditions. The study also provided prevalence estimates for subgroups based on demographic factors (age, sex), and found a consistent pattern throughout all years, sex, and age.Conclusions: The study analyzed the prevalence of AVN in case 1 and case 5, which were similar to the reference prevalence of 3.5 per 100,000 people reported in other countries. The study’s results are encouraging for several reasons, including the validity of the operational definitions used, and the agreement between the study’s prevalence estimates and the reference prevalence. The operational definition in statistics, in the context of big data, serves as a precise and standardized criterion.
Efectos socioeconómicos de la pobreza y discapacidad en México: 2020
Authors:   Universidad Autónoma de Sinaloa, Mora Tordecillas Jorge Eugenio de Jesús , Pérez Álvarez Gustavo Fabián ,   Universidad Autónoma de Sinaloa, Higuera Quintero Nataly ,   Universidad Autónoma de Sinaloa
Published: September 2023

La pobreza y la discapacidad son problemas sociales interconectados y complejos que afectan la calidad de vida de millones de personas en todo el mundo. A pesar de esta relación, ha recibido poca atención y la información disponible muestra que un número desproporcionado de personas con discapacidad vive en condiciones de pobreza extrema. La investigación tuvo como objetivo analizar los efectos de la pobreza y la discapacidad en la población mexicana. Este análisis se realizo mediante el calculo de pobreza del Consejo Nacional de Evaluación de la Política de Desarrollo Social (CONEVAL) 2020 mediante el programa STATA 13.0. Se encontró que la discapacidad eleva la prevalencia de la pobreza en la población en general en 6%. El grupo de edad más afectado fueron Menores y Jóvenes incrementando 20% la prevalencia de pobreza en presencia de la discapacidad. Si un jefe de familia presenta discapacidad eleva la prevalencia de la pobreza en 6.9%. El analfabetismo en presencia de discapacidad disminuye la prevalencia de pobreza. Cada integrante adicional de la familia con discapacidad aumenta en 9% la incidencia de pobreza. Se puede observar una incidencia diferenciada y muy marcada de la pobreza en personas con discapacidad.
The Effectiveness of E-Books in Learning: An Analysis of Trends in Elementary Schools
Authors: Saptono Bambang
Published: September 2023

Less than optimal student learning outcomes are a problem experienced by teachers in elementary schools. It is evidenced by the student learning outcomes that have not been maximized. The objective of this study is to provide a comprehensive description of the effectiveness of incorporating e-books into the learning process. This study used a quantitative approach with a time series design. The research subjects consisted of elementary school students and teachers. The student subjects involved came from the fifth-grade level. Data collection was done by testing and observation. Data analysis was performed by testing four trend models. These are the Linear Trend Model, Quadratic Trend Model, Growth Curve Model, and S-Curve Trend Model. The research findings indicate that e-books are a viable tool for facilitating learning in elementary school settings. It is based on the positive trend shown in student learning outcomes after applying the e-book as a learning tool. It strengthens the recommendation regarding implementing e-books by teachers to maximize student learning outcomes.
The Problem of Affordable Education in Indonesia: The Emergence of Online Tutoring Service in Primary Education Level
Authors: Cathrin Shely , Hanum Farida , Dwiningrum Siti Irene Astuti , Efianingrum Ariefa , Suyantiningsih Suyantiningsih , Hayashi Masami
Published: September 2023

The development of online tutoring services suggests that Indonesian education faces significant challenges. The purpose of this study is to investigate the issue of educational affordability that arises as a result of the creation of numerous tutoring services in Indonesia. This study used a descriptive research model and a qualitative methodology. This research data takes the form of literature from studies on the existence of elementary school tutoring institutions in Indonesia with all its issues, which are examined from a phenomenological point of view. The findings indicated that public mistrust in the caliber of education provided in formal schools contributed to the rise of online tutoring services at the elementary school level. Students are beginning to choose to employ online tutoring services due to tedious coursework and the ineffectiveness of learning implementation in traditional elementary schools. This article suggests that the government cooperate with the private sector and education innovators to create media and learning methods that are efficient, enjoyable, and still affordable for everyone to address the deficiencies in Indonesia's formal education system.
Bibliometric Analysis of Game Research Trends in Elementary Learning and Self-Regulated Learning Skill
Authors: Primaestri Wening , Akhyar Muhammad , Sutimin Leo Agung
Published: September 2023

Self-regulated learning is a skill that is important to be taught to students because this skill is useful in their learning environment management to achieve the best learning outcomes. Thus, teaching this ability as early as possible is better, such as in elementary school. One alternative way to introduce and teach this skill is through games. This study aims to capture the relevant previous research landscape regarding the use of games in elementary school learning and for self-regulated learning from 2020 to 2023 using bibliometric analysis with the help of the VOSviewer application. The Scopus database was used to search for data with the keywords "games", "self-regulated learning", "elementary education," and "primary education," which were then refined to become 196 journal article publications. From the results of this analysis, it was found that the trend of publications about the use of games in learning had appeared in 2020, but about self-regulated learning, game-based learning, and elementary/primary education had only appeared in 2021. The research focus can be divided into four major topics, namely: (1) the use of game and game-based learning in primary education, (2) child development, and (3) the use of technology used in primary school education. Surprisingly, there hasn’t been research on self-regulated learning in elementary education. Thus, further research and development on the topic can be done.
The Effect of Smartphone Uses and Parenting Style on the Honest Character and Responsibility of Elementary School Students
Authors: Abdurahman Ayi , Marzuki Kartini , Yahya M. Daud , Asfahani Asfahani , Pratiwi Endah Andriani , Adam Ketlin Aprijane
Published: September 2023

This study aims to analyze the effect of parenting and smartphone use on the honest and responsible attitude of Tipar Public Elementary School students. This study used a quantitative method with a survey method to investigate the relationship between smartphone use, parenting style, and the development of honest character and responsibility among elementary school students. Questionnaires were employed to collect data. The participants in this study were elementary school students. Tipar Elementary School will be chosen as a representative sample, and the sample size will be calculated based on statistical considerations and power analysis. The collected data were examined using relevant statistical techniques. This study reveals that parenting style positively affected students' honest and responsible attitudes by 26.3%. Smartphone use positively affects students' open and accountable attitudes by 24.0%. Parenting style has a positive effect on smartphone use, amounted 19.1%. Parenting parents and smartphones positively influence the honest and responsible mood of Tipar Public Elementary School students, 34.9%, and other factors influence the remaining 66.1%. As a result, the more positive parents' attitudes toward their children, the more honest and responsible students become. The greater students use smartphones, the better their open mindset and responsibility. Similarly, the better the parenting style and the usage of smartphones, the better students’ honesty and responsibility. In contrast, the more severe the parenting style and the use of smartphones, the lower the students' open thinking and responsibility would be.
Religious Character Education in Term of Moral Knowing: A Case Study at an Elementary School in Surakarta
Authors: Susilowati Arum , Fauziati Endang , Rahmawati Fitri Puji , Rahmawati Laili Etika
Published: September 2023

The purpose of this study is to find out and analyze: (1) how is the implementation of religious character education in term moral knowing students in classroom learning, (2) how is the implementation of religious character education in term moral knowing students into extracurricular programs, (3) how is the implementation of religious character education in term moral knowing student in self-development programs at an Elementary school in Surakarta. This study used a descriptive qualitative approach. Data collection techniques use interviews, observations, and documentation studies. The primary data sources were obtained from the results of researcher’s observations and interviews with school principals, teachers of the Aqidah Akhlak subject, classroom teachers and 31 students in class 4A at an Elementary school in Surakarta. While the secondary data was obtained by researchers from existing sources in the form of evidence, notes and files. Data is analyzed by performing data reduction, data presentation, and data verification. The results of the research show that the implementation of religious character education in term moral knowing students in learning Fiqh, Arabic, Aqidah Akhlak, Al-Qur'an and Hadits, and Kemuhammadiyahan. The implementation of religious character education in term moral knowing students into extracurricular programs is calligraphy, tapak suci, hizbul wathan and tahfidz Qur'an. Implementation of religious character education in term moral knowing student in self-development programs is the habit of praying dhuha, Friday infaq, cultum, tadarus, Friday prayers, dhikr after prayers, memorizing verses of the Al-Qur’an, memorizing short hadits and memorizing daily prayers at an Elementary school in Surakarta.
The Development of Collaborative-Based Learning Models to Increase Self-Efficacy and Positive Attitudes of Primary Teacher Education Students towards Inclusive Education in Yogyakarta
Authors: Wati Unik Ambar , Hermanto Hermanto , Rahmadonna Sisca , Pujaningsih Pujaningsih , Komalasari Mahilda Dea , Pratama Kukuh Wahyudin
Published: September 2023

This study attempts to develop a collaborative-based learning model that can increase self-efficacy and positive attitudes of Primary Teacher Education (PGSD) students toward inclusive education in Indonesia. This study is intended to provide an understanding to PGSD students who are also teacher candidates. The understanding is about the importance of positive attitudes and teaching abilities, which in this study are limited in self-efficacy. The present study employed the Research and Development (R D) research model. The research participants were elementary school teachers who teach in inclusive schools and 54 PGSD students. Quantitative and qualitative techniques were used to analyze the data. Mann–Whitney U test was used to determine changes in students’ self-efficacy and attitudes before and after learning activities. The results indicate a significant difference in self-efficacy with p sig 0.05. The t-test result is 0.119. As the tcount is greater than the ttable (0.119 0.05), it indicates that there is no significant difference. Hence, it can be inferred that there is no statistically significant difference in developing a collaborative-based lecture model aimed at enhancing self-efficacy and fostering favorable attitudes among PGSD students towards inclusive education in Yogyakarta.
The Implementation of Tut Wuri Handayani Values at the Taman Muda Elementary School Jetis Yogyakarta
Authors: Sugiyanto Sugiyanto , LN Syamsu Yusuf , Supriatna Mamat
Published: September 2023

This research aims to examine the noble values contained in tut wuri handayani and its implementation in education, which holds meaning as an educator or pamong who plays a role in developing students' abilities through the influence of education by providing freedom in learning to find the meaning of life. The research approach used in this study was phenomenology. The research method employed was hermeneutic phenomenology, which focuses on life experiences and interpreting the "text" of life. Data collection techniques include library research and interviews. The data sources consisted of writings by Ki Hadjar Dewantara on the noble values of tut wuri handayani, interviews with Tamansiswa figures, and interviews with the school principal and pamong of Taman Muda Jetis Elementary School. Data analysis was conducted using Interpretative Phenomenological Analysis (IPA). The research findings indicate that the values contained in tut wuri handayani can be applied in educational institutions to shape students who are independent in their thinking, inner selves, and abilities by avoiding behaviors contrary to the rules and norms.
Computed tomography as a risk factor of cancer among the population of the nuclear city of Ozyorsk
Authors:   Southern Urals Biophysics Institute of FMBA of Russia, Osipov M.V.
Published: September 2023

Exposure to ionizing radiation resulted from computed tomography (CT) examinations concerns a risk associated with potential radiation-induced cancers. Widespread use of this diagnostic method during the last decades has led to significant increase of collective dose of the world’s population. Minor dose restrictions for diagnostic X-ray procedures involve considerable “beneficial” exposure burden among CT-examined patients. Assessment of possible consequences became necessary in order to manage potential risks in terms of “benefit-harm” control. Retrospective epidemiological study has been performed using the cohort of individuals exposed to diagnostic radiation from CT. The source of information was the “CT Register” database which contains medical and dosimetric data on the population of nuclear city of Ozyorsk, including data on several potential risk factors such as gender, age at exposure, cancer anamnesis and contact with occupational radiation. Risk calculation was performed using conditional logistic regression. A hypothesis on increasing chances of developing of malignant neoplasm depending on the number of recurrent CT during the lifetime, taking into account potential confounders and the impact of reverse causation was tested. The relation between recurrent CT examinations and the subsequent malignant neoplasm (OR 1.01-1.10) can be confirmed at (1-alpha) 90%, which indicates the probable radiogenic component of carcinogenic risk. Further investigation with expanded follow-up period will facilitate accounting possible unrealized cancer cases with long latency period and improve the results of the study.
Dynamics of formation of absorbed doses in the blood of laboratory animals from alpha-emitting radionuclides with successive decays
Authors:   Omsk State Medical University of the Ministry of Health of the Russian Federation, Matveev A.V. , Petriev V.M. ,   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC)
Published: September 2023

Since the beginning of the XXI century, active research has begun on the development of fundamentally new radiopharmaceutical drugs based on alpha-emitting maternal radionuclides for radionuclide therapy of micro-tumors and metastases. The main difficulty in assessing the absorbed doses of internal irradiation of such drugs is to take into account the radiation loads from all daughter radionuclides of sequential decay with alpha and beta transformations. The aim of the work is to develop a methodology for calculating the accumulated and total absorbed doses in the blood of laboratory animals from alpha-emitting radionuclides with successive decays within the framework of the compartment modeling method. To test the developed methodology and calculate the dosimetric characteristics, the free isotope Ac-225, injected into the blood as part of its chloride Ac-225Cl3, and the osteotropic preparation Ac-225-KHEDP (monokalium salt of hydroxyethylidendiphosphonic acid) labeled with it were selected. Quantitative data on the bio-distribution of Ac-225-KHEDP and Ac-225Cl3 in the body of intact mice were used to identify the necessary parameters. Calculations of the dosimetric characteristics of two Ac-225-labeled drugs in the blood of intact mice showed that the values of accumulated absorbed doses monotonically increase from the moment of drug administration, reaching their limit values equal to the total absorbed doses by about 300 hours. Alpha-emitting parent and daughter radionuclides make the main contribution to the values of total absorbed doses. The contribution of daughter beta-emitting radionuclides is significantly less, therefore, they can be ignored when preliminary estimates of the total absorbed doses are made. When using Ac-225-KHEDP, all radiation loads on the blood are approximately 2.5 times less compared to Ac-225Cl3, which is explained by the higher blood clearance value for Ac-225-KHEDP. The results obtained indicate the prospects for further studies of 225Ac-KHEDP and the possibility of its clinical application for the treatment of skeletal metastases.
Linear threshold effects of gamma-irradiation of the terrestrial mollusk F. fruticum M. of the third age group
Authors:   Bauman Moscow State Technical University (Kaluga Branch), Lavrentyeva G.V. , Cherkasova E.E. ,   Obninsk Institute for Nuclear Power Engineering, Mirzeabasov O.A. ,   Obninsk Institute for Nuclear Power Engineering, Shoshina R.R. ,   Obninsk Institute for Nuclear Power Engineering, Synzynys B.I. ,   Obninsk Institute for Nuclear Power Engineering
Published: September 2023

The ecocentric strategy of radiation protection involves the expansion of experimental bases of radiation-induced effects in representatives of biota. In this article we studied the change in the relevant indicator (mortality) of the terrestrial mollusk F. fruticum M. after gamma-irradiation with doses from 10 to 300 Gy. The terrestrial mollusk is not yet included in the list of reference species, but it meets the requirements of the ICRP for reference organisms. The aim of the work is to establish dose-effect relationships in the study of mortality of the terrestrial mollusk F. fruticum M. The third age group after acute -irradiation is used to expand databases on radio-induced effects of biota. The results of a study for mollusks of only the third age group are presented. This research is part of an experiment to identify age-related features of radiosensitivity of a representative of terrestrial malacofauna. The age of the mollusks was determined by the number of revolutions of the shell. The conditions for keeping animals in laboratory were selected in such a way that mortality in the control group remained at zero during the entire experiment. The duration of the experiment is 210 days. The LD50/60 index for the mollusk was estimated by the calculated probit analysis method using the least squares method. The LD50/60 is 141.4+/-26.3 Gy. The change in the indicator was estimated every 30 days after irradiation. A linear threshold dependence was established for each time range, starting from 60 days after irradiation. It contains two threshold transitions to a new level of mortality and, accordingly, three dose ranges: a dose-independent range at low doses of radiation, a dose-dependent range with an increase in the dose of radiation and a dose-independent plateau when switching to the level of absolute lethality. Four dose ranges of mortality of terrestrial mollusks were established for 210 days after irradiation: 10-130 Gy (100% survival rate), 140-160 Gy (absolute mortality after 180 days), 170-190 Gy (absolute mortality after 150 days), 200-300 Gy (100% mortality after 90 days). At the same time, the greatest dynamics of the increase in mortality is observed in the first 60 days after irradiation.
Association between the rs1052133 polymorphism of the OGG1 gene and the risk of malignant neoplasms development in people chronically exposed to radiation
Authors:   Urals Research Center for Radiation Medicine of FMBA of Russia, Yanishevskaya M.A. , Blinova E.A. ,   Urals Research Center for Radiation Medicine of FMBA of Russia,   Chelyabinsk State University, Korechenkova A.V. ,   Urals Research Center for Radiation Medicine of FMBA of Russia, Akleyev A.V. ,   Urals Research Center for Radiation Medicine of FMBA of Russia,   Urals Research Center for Radiation Medicine of FMBA of Russia
Published: September 2023

Genetic predisposition without doubt is one of the risk factors of cancer initiation. It is known that single nucleotide polymorphisms (SNP) of genes that maintain the genome stability, including SNP of DNA repair, may contribute to the initiation of carcinogenesis. Single-nucleotide polymorphisms of genes that support genome stability, including SNP of DNA repair genes, can contribute to cancer initiation. Polymorphism of the excision repair gene OGG1 causes interest of leading scientific groups from various countries. It is assumed that there is relationship between the rs1052133 polymorphism in the gene and predisposition to cancer initiation. The objective of this study was to establish association between rs1052133 polymorphism of base excision repair gene OGG1 and the risk of cancer initiation in people chronically exposed to ionizing radiation. Residents (888 people) of the Techa riverside settlements, chronically exposed to low or medium radiation from the Techa River and the East-Urals Radioactive Trace were included in the study. The study allowed researchers to establish that exposed to chronic radiation people, carriers of the rs1052133*G allele have increased risk of malignant neoplasms initiation: OR=1.38; 95% CI [1.05-1.83], p=0.023. The multifactorial synergistic interactions between the dose to the red bone marrow and the rs1052133 polymorphism of the OGG1 gene was found: Testing Balanced Accuracy (TBA)=0.56; Cross Validation Consistency (CVC)=10/10; p=0.01). The study found that the rs1052133 polymorphism may be considered as genetical marker of risk of cancer initiation in people, chronically exposed to radiation with doses ranged from 0.74 to 3507.07 mGy (average 523.10+/-33.89 mGy). It was found that the presence of the rs1052133*G in combination with radiation exposure can modify the risk of solid cancers initiation, as it is indicated by the synergistic relationship between the SNP and the radiation dose.
Inclusion of Dietary-Fibers in Nutrition Provides Prebiotic Substrates to Probiotics for the Synthesis of Beneficial Metabolites SCFA to Sustain Gut Health Minimizing Risk of IBS, IBD, CRC
Authors: Dahiya Divakar , Singh  NIGAM Poonam
Published: September 2023

Usually, everyday meals constitute materials and ingredients for food preparation derived from different agricultural sources. Although most customers are aware of the benefits of a balanced diet, they mainly focus on a diet based on the daily requirements of protein, fat, and carbohydrates in their meals. However, the vital aspect of the including dietary fibers in diets is overlooked, which is equally important as is the daily requirement of calories and protein intake for maintaining the muscle mass. Some societies consume a diet heavily based on animal-sourced materials, which is deficient in components of plant-derived beneficial fibers. In such consumers, the smooth functioning of the digestive system and the overall metabolism could be affected in due course of time. As a result, their excretion system would be adversely influenced. The long-term irregularities in the alimentary system might be a cause of the initiation of a problem, particularly in the colon. Foods are natural therapeutics to sustain the healthy functioning of the gastrointestinal tract (GIT), which is also interconnected with other systems impacting the physiology of the human body. Consumers generally select their meals according to their personal choice and taste, and their nutrition is geographically influenced. However, the dietary fibers (prebiotics) sourced from various agricultural materials can be easily included as a constituent of food for the survival and metabolism of probiotic cultures resident in consumers’ GIT. This article aims to review information available on plant-derived dietary fibers and their role in the functioning of probiotic microorganisms resident in the gastrointestinal tract, which is important for managing gut health, thereby minimizing inflammatory gut issues.
Available Assistive Technology Outcome Measures: Systematic Review
Authors: Borgnis Francesca , Desideri Lorenzo , Converti Rosa Maria , Salatino Claudia
Published: September 2023

Background

The World Health Organization claimed that measuring outcomes is necessary to understand the benefits of assistive technology (AT) and create evidence-based policies and systems to ensure universal access to it. In clinical practice, there is an increasing need for standardized methods to track AT interventions using outcome assessments.

Objective

This review provides an overview of the available outcome measures that can be used at the follow-up stage of any AT intervention and integrated into daily clinical or service practice.

Methods

We systematically searched for original manuscripts regarding available and used AT outcome measures by searching for titles and abstracts in the PubMed, Scopus, and Web of Science databases up to March 2023.

Results

We analyzed 955 articles, of which 50 (5.2%) were included in the review. Within these, 53 instruments have been mentioned and used to provide an AT outcome assessment. The most widely used tool is the Quebec User Evaluation of Satisfaction with Assistive Technology, followed by the Psychosocial Impact of Assistive Technology Scale. Moreover, the identified measures addressed 8 AT outcome domains: functional efficacy, satisfaction, psychosocial impact, caregiver burden, quality of life, participation, confidence, and usability. The AT category Assistive products for activities and participation relating to personal mobility and transportation was the most involved in the reviewed articles.

Conclusions

Among the 53 cited instruments, only 17 (32%) scales were designed to evaluate specifically assistive devices. Moreover, 64% (34/53) of the instruments were only mentioned once to denote poor uniformity and concordance in the instruments to be used, limiting the possibility of comparing the results of studies. This work could represent a good guide for promoting the use of validated AT outcome measures in clinical practice that can be helpful to AT assessment teams in their everyday activities and the improvement of clinical practice.
Efficacy and safety of Pediatric Massage for Allergic rhinitis : A protocol for systematic review and meta-analysis (Preprint)
Authors: Zeng Qiaoqiao , Li Jingnan , Yan Huixin , Bi Yunpeng , L Xiaojie , Wu Qin , Zhuo Yue
Published: September 2023

BACKGROUND

Allergic rhinitis (AR) is a disease that seriously affects children's daily life. Pediatric massage is widely used in clinical practice for the treatment of this disease and has achieved good therapeutic effects.However, the effectiveness, safety, and advantages of this method have not been confirmed by high-quality meta-analysis. The purpose of this study is to evaluate the effectiveness and safety of pediatric massage therapy for pediatric AR patients.

OBJECTIVE

The aim of this systematic review protocol is to assess the efficacy and safety of Pediatric Massage for the treatment of children with AR.

METHODS

Randomized controlled trials (RCTs) related to Pediatric Massage treatment of Allergic rhinitis will be retrieved from the Chinese or English databases or Clinical Trial Register. These databases include CNKI, Wan Fang, CBM, VIP, PubMed, Embase, Web of Science, Cochrane Library and Medline, etc. We will consider articles published in English or Chinese. If the inclusion criteria are met, our team will use Revman 5.3 software provided by the Cochrane Collaborative Network to conduct this systematic review and meta-analysis.

RESULTS

This study will provide a comprehensive scientific evaluation of the efficacy and safety of Pediatric Massage therapy for AR.

CONCLUSIONS

The results of this systematic review and meta-analysis will be published in a peer-reviewed journal, which will provide evidence and reference for clinicians to use Pediatric Massage therapy to treat AR.

CLINICALTRIAL

PROSPERO CRD42023452842; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=452842
Adaptive Filter in Single Image SRGAN
Authors: Bera Atin , Bhattacharjee Arya , Ghosh Debmitra
Published: September 2023

Abstract: SRGAN is a generative adversarial network for super-resolution of a single picture. In this paper an adaptive filter in single image SRGAN which is a Super-Resolution Generative Adversarial Network (SRGAN), is a deep learning-based approach that is used to generate high-resolution images from low-resolution ones. The SRGAN model is based on the Generative Adversarial Network (GAN) architecture, which consists of two deep neural networks: a generator network and a discriminator network. The generator network takes a low-resolution image as input and tries to generate a high-resolution image that is similar to the original high-resolution image. The discriminator network, on the other hand, tries to distinguish between the high-resolution images generated by the generator network and the original high-resolution images. The SRGAN model has been shown to be very effective in generating high-quality, realistic images from low-resolution inputs, and it has been applied in various applications, including image and video upscaling, medical imaging, and satellite imaging
INVESTIGATION OF THE RELATIONSHIP BETWEEN BODY AWARENESS AND PHYSICAL ACTIVITY AND STRENGTH LEVELS OF YOUNG ATHLETES
Authors: ASAN Selim
Published: September 2023

People can use and accept their bodies at the highest level through body awareness. Someone who is aware of their body and understands its details can see the effects of physical activity on the body. In line with this information, this research aimed to investigate the relationship between body awareness, physical activity and strength levels of young athletes. Seventy-six male athletes with an average age of 17.30±.462, an average body weight of 62.19±6.98 kg, an average height of 1.73±.069 cm, and an average BMI of 20.54±1.49 kg.m-2 participated in the research. As a data collection tool in the research, “Personal Information Form,” “Body Awareness Questionnaire (BAQ),” “International Physical Activity Questionnaire Short Form (IPAQ-SF),” “Sitting Medicine Ball Throwing Test,” “Hand Grip Strength Test (HGST)” and “Back and Leg Strength Test” was used. The research data were analyzed with the Pearson Correlation Test and One Way ANOVA Test, which are descriptive statistics. As a result, it was determined that as the total physical activity of the individuals increased, their body awareness levels also increased. At the same time, a significant positive correlation (p
A SOBRECARGA DO FAMILIAR DA PESSOA COM ESQUIZOFRENIA: uma revisão sistemática
Authors: Oliveira Aislan José de , Casanova Gabriele Bueno , Ferro Luiz Roberto Marquezi
Published: September 2023

Introduction: Schizophrenia is one of the mental disorders classified as highly incapacitating, promoting a greater exclusion of this individual from his tasks performed, and from his social life. The definition of this diagnosis, although necessary, causes changes not only for this individual, but also affects his family. Objective: This article aims to investigate the occurrence of overload in family caregivers of individuals diagnosed with schizophrenia. Methods: The research consists of a systematic review of the literature with a qualitative, descriptive and exploratory approach. For the survey of articles in the literature, the following databases were consulted, Scielo, PePsic and the VHL Regional Portal, using the descriptors schizophrenia, burden and caregiver, and the keyword “family”, the search operator used was “and”. Results: The results found, in the selected articles, agree and point to the difficulties experienced by caregivers in the social, economic and health fields, causing high levels of burden. Conclusions: We conclude that by understanding more about the psychological impacts of family members when receiving the diagnosis of schizophrenia from their family members, we make it possible, in addition to greater knowledge of the topic about the total impact on the family, to plan strategies to minimize the impacts in family organization and structure, promoting better quality in the face of the reality of the mental disorder.
Encoding trade-offs and design toolkits in quantum algorithms for discrete optimization: coloring, routing, scheduling, and other problems
Authors: Sawaya Nicolas PD , Schmitz Albert T , Hadfield Stuart
Published: September 2023

Challenging combinatorial optimization problems are ubiquitous in science and engineering. Several quantum methods for optimization have recently been developed, in different settings including both exact and approximate solvers. Addressing this field of research, this manuscript has three distinct purposes. First, we present an intuitive method for synthesizing and analyzing discrete (i.e., integer-based) optimization problems, wherein the problem and corresponding algorithmic primitives are expressed using a discrete quantum intermediate representation (DQIR) that is encoding-independent. This compact representation often allows for more efficient problem compilation, automated analyses of different encoding choices, easier interpretability, more complex runtime procedures, and richer programmability, as compared to previous approaches, which we demonstrate with a number of examples. Second, we perform numerical studies comparing several qubit encodings; the results exhibit a number of preliminary trends that help guide the choice of encoding for a particular set of hardware and a particular problem and algorithm. Our study includes problems related to graph coloring, the traveling salesperson problem, factory/machine scheduling, financial portfolio rebalancing, and integer linear programming. Third, we design low-depth graph-derived partial mixers (GDPMs) up to 16-level quantum variables, demonstrating that compact (binary) encodings are more amenable to QAOA than previously understood. We expect this toolkit of programming abstractions and low-level building blocks to aid in designing quantum algorithms for discrete combinatorial problems.
Quantum Gauge Networks: A New Kind of Tensor Network
Authors: Slagle Kevin
Published: September 2023

Although tensor networks are powerful tools for simulating low-dimensional quantum physics, tensor network algorithms are very computationally costly in higher spatial dimensions. We introduce quantum gauge networks: a different kind of tensor network ansatz for which the computation cost of simulations does not explicitly increase for larger spatial dimensions. We take inspiration from the gauge picture of quantum dynamics, which consists of a local wavefunction for each patch of space, with neighboring patches related by unitary connections. A quantum gauge network (QGN) has a similar structure, except the Hilbert space dimensions of the local wavefunctions and connections are truncated. We describe how a QGN can be obtained from a generic wavefunction or matrix product state (MPS). All 2k-point correlation functions of any wavefunction for M many operators can be encoded exactly by a QGN with bond dimension O(Mk). In comparison, for just k=1, an exponentially larger bond dimension of 2M/6 is generically required for an MPS of qubits. We provide a simple QGN algorithm for approximate simulations of quantum dynamics in any spatial dimension. The approximate dynamics can achieve exact energy conservation for time-independent Hamiltonians, and spatial symmetries can also be maintained exactly. We benchmark the algorithm by simulating the quantum quench of fermionic Hamiltonians in up to three spatial dimensions.
Commanders by the Will of the Senate: Governors of the Senate Provinces in the Military Command System during the Period of the Early Roman Empire
Authors: Telepen Sergey Valer’evich
Published: September 2023

The relevance of the research topic is due to the insufficient study of the role of the governors of the Senate provinces in the military command system of the early Roman Empire. Completion of this knowledge is necessary both for studying the military organization of Rome, and for revealing the essence of the Roman state-political system. The purpose of the study is to find the legal and ideological grounds for the military status of the governors of the senatorial provinces, which, in the author’s opinion, should be resolved primarily in the context of considering the issue of imperium militiae of such governors. In the absence of direct indications in this regard in the sources, the method of reconstruction was the analysis of specific material (including prosopographic), reflecting the military functions of the governors appointed by the Senate. The author made an attempt to find out the commander’s status of the governors by finding a full-fledged imperium militiae in them. The author’s conclusion: throughout the entire period of the early Empire, the governors of the senatorial provinces retained their imperium militiae, continuing to carry out the functions of a military leader, although to a much lesser extent than at the beginning of the period. Such governors remained an important element in the system of military command, especially in critical situations that regularly arose even in the «pacified» provinces.
Alkaios - a true citizen of Mytilene
Authors: Solomatina Elena Ivanovna
Published: September 2023

The article is devoted to the civic position and political views of Alkaios, a fighter against tyranny, and his opponent Pittacus, the tyrant of Mytilene. The purpose of the study is to identify the presence or absence of political differences between Alkaios and Pittacus based on an analysis of all available sources. The author proves that the political views of Alkaios and Pittacus coincided and did not change throughout the entire period of their joint actions. According to the author, the situation changed due to the role of Pittacus in the victorious end of the first stage of the Sigean War. Conclusions: Pittak decided to seize power by changing allies. Having established tyranny, he did not radically reform the state system, supplementing the traditional regime with personal authoritarian power.
Hoplitodromos - the category of ancient Greek athletics
Authors: Gvozdeva Tatiana Borisovna
Published: September 2023

The purpose of the study is to find out whether the hoplitodromos, or hoplite race, was more of a military or sporting event, whether the nature of this agon was associated with its late introduction into the program of the Panhellenic games, and whether the rules for its organization differed in Panhellenic and local competitions. On the basis of written sources and data from Attic vase painting, the author shows that there were different types of weapons of the participants in the run - heavy and light, and also that over time the “full” weapons of the hoplite - helmet, greaves, shield - change, retaining only the shield. Despite the widespread opinion in the scientific literature that the hoplitоdromos belonged to “military” competitions, the author comes to the conclusion that the nature of the run was determined by the type of games. And if at local games this agon was often associated with the aition of the festival, for example, with the military exploits of Athena on Panathenaia or the anniversary of the Battle of Plataea on Eleutheria, then at Panhellenic competitions, such as the Olympic Games, the military nature of the run was transformed into a reconstruction, thereby acquiring the nature of an entertaining spectacle.