bluuebunny/crossref_metadata_2025 huggingface dataset:
One Year of Peer Support Work in Forensic Mental Health – Evaluation of Implementation
Authors: Walde P. , Benz C. , Hadala J. , Völlm B.
Published: September 2022

Introduction

Peer Support Work can be an effective way to support patients and their participation also in psychiatric populations. Unlike in general psychiatry there is less experience with peer support work in forensic mental health inpatient settings. Characteristics different from general psychiatry, e.g., regarding safety, might be a reason for the delay of their implementation.

Objectives

We aim to present the implementation of a peer support worker in a forensic mental health setting for addicted offenders. We address reservations of staff before the implementation and their development during the first year. The perspective of patients about their experiences is taken into consideration. The development of the peer support workers position and tasks is demonstrated.

Methods

Focus groups and interviews were conducted with several groups of people, amongst them employees of several professions, patients and the peer support worker of the clinic. Interviews and focus groups were recorded and transcribed for thematic analysis.

Results

Reservations of staff comparable to these found in general psychiatry occurred in the forensic mental health professionals. These could be diminished during the first year. Most of the patients were able to accept and trust the peer support worker, in some cases after initial mistrust. The peer support worker felt accepted in the team and was able to develop a routine as well as own tasks.

Conclusions

The experiences from one year testified that implementation of peer support work into a forensic mental health inpatient setting is possible. Further patient outcomes are to be explored but the current results are promising.

Disclosure

No significant relationships.
Selective serotonin reuptake inhibitors and violent crime: do SSRI’s kill or cure?
Authors: Sneep S. , Petrykiv S.
Published: September 2022

Introduction

SSRI’s are consistently associated with violent events in the adult population. However, the causality between SSRI use and violent behaviour was never found. Several recent studies draw the attention to this hypothesis while they were inspired by several mass murderers in the United States.

Objectives

A literature research on studies exploring the association between SSRI use and violent behaviour.

Methods

The authors performed a literature search (1966–2020) using PubMed and Embase to review studies where a possible link between SSRI’s and violent behaviour in adults was assessed.

Results

94 studies were identified, of which 6 studies were included. There is no association between the use of SSRI’s and violent behaviour in the general population. However, an increased hazard of violent behaviour was observed in young man and those with a history of violent crime.

Conclusions

Overall, SSRI treatment is safe in the general population. Certain subgroups can, however, be vulnerable to aggressive flare-ups, especially during on-treatment period and the first 12 weeks after drug discontinuation. Therefore, careful monitoring throughout these critical periods is strongly recommended.

Disclosure

No significant relationships.
Burnout among early career psychiatrists in Russia – results of a cross-sectional study
Authors: Chumakov E. , Gvozdetsky A. , Petrova N.
Published: September 2022

Introduction

Despite the long history of burnout studies, the problem of burnout among psychiatric specialists in Russia is insufficiently studied. The risk of burnout is the highest among psychiatrists in the first 10 years of their career.

Objectives

To assess the prevalence and severity of burnout in early career psychiatrists (ECPs) in Russia.

Methods

An anonymous online survey of ECPs in Russia was conducted in July-August 2019 with a screening for burnout using the Maslach Burnout Inventory (MBI). The final sample consisted of 165 people (61.2% women; mean age 31.05±3.88). 95.2% of respondents lived in urban areas.

Results

A high level of burnout according to at least one of the MBI scales was revealed in 71.5% of ECPs: in 79 (78.2%) women and 39 (60.9%) men (χ2(1)=5.74; p=0.017). Mean values of the MBI Emotional Exhaustion scale corresponded to 23.33±8.97 and 17.97±8.49 (U=1999.5; p=0.003), the MBI Depersonalization scale – 10.46±4.81 and 9.16±4.22 (U=2598.5; p=0.083), and the MBI Personal Accomplishment scale – 33.02±5.98 and 35.32±5.75 (U=2409.5; p=0.026) for women and men, respectively. The following risk factors for professional burnout were identified: female sex (OR=3.54 [95% CI: 1.96; 6.39], p<0.001), overlapping of several working positions (OR=2.44 [95% CI: 1.36; 4.37], p=0.003), difficulties in work due to changes in documentation requirements introduced since the start of career (OR=2.32 [95% CI: 1.31; 4.11], p=0.004).

Conclusions

A high frequency of burnout among ECPs in Russia was revealed which suggests the urgent need for studies assessing the ways to prevent burnout in psychiatrists in Russia.

Disclosure

No significant relationships.
Medically unexplained somatic symptoms and its association with functionality and childhood trauma in type-1 bipolar disorder
Authors: Usta Saglam N.G. , Ayık B. , Baş A. , Izci F.
Published: September 2022

Introduction

Somatic symptoms with the heterogeneous character that are not fully explained by a medical condition are common in bipolar disorder (BD) which might interfere with the choice of treatment, health care utilization, medical costs as well as functionality.

Objectives

The purpose of this study was to evaluate somatic symptoms in remitted type 1 BD and to examine the association of somatization, functionality, and childhood trauma which is a known mediator of adult somatization.

Methods

After excluding patients with medical comorbidities, 61 patients diagnosed with BD type-1 according to the Diagnostic and Statistical Manual of Mental Disorders-V (DSM-V) participated in the study. We required at least 8 weeks of remission and confirm it with Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS). Somatization Scale, Functioning Assessment Short Test (FAST) and Childhood Trauma Questionnaire (CTQ) were administered to the participants.

Results

Somatization scores were significantly correlated with CTQ (r=.310, p=.016), FAST- total (r=.307, p=.016), FAST-financial issues (r=.357, p=.005) and FAST-interpersonal relationships (r=.320, p=.012) subscale scores while inversely correlated with years in education (r=-,305, p=.017). When a partial correlation was run to determine the relationship between somatization and functioning whilst controlling for childhood trauma, there was no statistically significant correlation between somatization and functioning (p=.076).

Conclusions

Our study suggests childhood trauma may have a major influence on the relation between somatization and functionality in patients with type- 1 BD. When addressing physical symptoms in patients with type-1 BD, an integrated approach including childhood trauma should be considered.

Disclosure

No significant relationships.
Overlapping of clinical symptoms between schizophrenia and bipolar disorder
Authors: Tahirovic A. , Arnautović Tahirović M. , Muhic M. , Sikira H. , Sulejmanpasic G. , Haracic Curovac L. , Cesir A. , Memic Serdarevic A.
Published: September 2022

Introduction

Schizophrenia (SCH) and bipolar affective disorder (BP) are complex disorders that overlapping both in their clinical symptoms and certain familiar characteristics. They share some common characteristcs but there are also key differences. The frequency of overlapping symptoms between these diseases could give us more information about the current validity of the diagnosis based on existing diagnostic criteria. Similarities within and between these two disorders in the future, can possibly redefine greater reliability of diagnosis.

Objectives

The aim of the study was to investigate the frequency of overlapping symptoms between BP and SCH.

Methods

The sample included 159 patients diagnosed with SCH and 61 with BP who were followed over a two year period. The research was conducted at the UCCS Psychiatric Clinic. Assessment of clinical symptoms and diagnosis were performed using a structured clinical interview (SCID I), a list of operationalized criteria (OPSCRIT), a scale for the assessment of positive and negative symptoms (PANSS), a scale for the assessment of manic symptoms (YMRS).

Results

The overall PANSS score was significantly higher in patients with SCH compared to patients with BP, but on the general psychopatology there are no significant differences betwen SCH and BP. Symptoms of mania are significantly more pronounced in patients with BP compared to those with SCH.

Conclusions

Our results of overlapping of individual symptoms between SCH and BP can speak infavor of the theory of disease continuum. And can also help us in understanding symptoms and guide us to develop optimal treatment strategies.

Disclosure

No significant relationships.
Altered Complement System Activity in Schizophrenia: Overexpression of C4 and/or Abnormal Expression of Complement Control Proteins in the DLPFC, Parietal Cortex, Temporal Cortex, Associative Striatum, Hippocampus, Cerebellum and Whole Blood
Authors: Rey R. , Leboyer M.
Published: September 2022

Introduction

In schizophrenia, abnormal synaptic pruning during adolescence may be due to an altered Complement system activity. While this hypothesis is supported by C4 overexpression in various brain regions of individuals with schizophrenia, such alterations should be replicated and extended to other brain regions relevant to schizophrenia. Moreover, transcriptional studies of genes coding for proteins regulating the Complement system activity are lacking. Furthermore, it remains unknown whether cerebral and peripheral expression of C4 and Complement control proteins (CCP) are related.

Objectives

To identify altered expression of C4 and CCP (CSMD1, CSMD2, CD46) coding genes at the cerebral and peripheral levels in schizophrenic individuals.

Methods

We explored C4 and CCP coding genes expression at the cerebral and peripheral levels. Using shinyGEO application we analyzed gene expression from eight Gene Expression Omnibus datasets obtained from 196 schizophrenic individuals and 182 control subjects. First, we compared gene expression between schizophrenic patients and controls in postmortem cerebral samples from 7 different brain regions. Then, we compared gene expression between schizophrenic patients and controls in 4 peripheral tissues.

Results

We observed C4 overexpression in the DLPFC, parietal, temporal cortex and associative striatum of schizophrenic individuals. We report altered transcriptional patterns of CCP genes in the DLPFC, hippocampus and cerebellum of schizophrenic individuals. CD46 expression was altered in opposite directions between brain and blood of schizophrenic individuals. No significant alteration of C4 expression was observed in peripheral tissues.

Conclusions

Our results support the hypothesis of an altered Complement system activity in various brain regions of schizophrenic individuals which may disrupt the synaptic pruning process during adolescence.

Disclosure

No significant relationships.
New categories of psychiatric disorders related to mild neuroinflammation-autoimmune psychosis, mild encephaliutis
Authors: Bechter K.
Published: September 2022

Introduction

The mild encephalitis hypothesis(ME) ( Bechter 2001, NPBR; updated Bechter 2013,Progr NP&BP) proposed that mild neuroinflammation triggered by infections, autoimmunity, trauma or toxicity (including from stress) might causally underly a spectrum of severe mental disorders (SMDs), especially disorders of the schizophrenic and affective spectrum.

Objectives

The development from ME hypothesis to the new diagnoses of Autoimmune Psychosis (AP) and a subgroup of Autoimmune Encephalitis (AE) and beyond into future research is reviewed and discussed.

Methods

Expert review

Results

The subgroup of AE with exclusive or predominant psychiatric symptoms ( compare Graus et al 2016) and all cases of AP ( Pollak et al,Lancet Psychiatry 2020) match the previous poposed ME criteria. AE and AP can now successfully be treated in majority of cases by immune modulatory treatments. These new insights challenge both, the implementation of diagnosis and treatment into clinical reality and forthcoming research on the causality underlying severe mental disorders (SMDs). CSF studies showed in 50-70% of therapy resistant cases of affective and schizophrenic spectrum disorders some abnormalities compatible with mild neuroinflammation ( Bechter et al 2010, J Psych Res), recently confirmed in large patient samples from various university hospitals in Germany ( Endres et al 2018 aso., Rattay et al 2021, aso.).Also post mortem findings are compatible with ME hypothesis in a larger subgroup of SMDs. Open questions of new clinical categorization by refined grading of mild neuroinfalmmation by improved diagnostic methods appear increasingly required, which will be discussed ( Bechter Frontiers Psychiatry 2020).

Conclusions

Mild neuroinflammation appears causally involved in SMD

Disclosure

No significant relationships.
Fatal drug poisonings in an industrial region of the Far North of Russia
Authors: Novikov A. , Gil A.
Published: September 2022

Introduction

Drug poisonings is a continuous public health problem in Russia and worldwide.

Objectives

The objective of the study was to provide characteristics of lethal drug poisonings in a northern Russian region.

Methods

The data on deaths from drug poisoning that occurred between 2018 and September 2021, systematically collected by the Regional Center on the Organization of the Narcological and Psychiatric service of the Khanty-Mansi Autonomous Okrug of Russia, was analyzed.

Results

Among 220 cases of fatal drug poisoning the overwhelming majority (90.4%) occurred among males. The number of cases increased annually from 27 in 2018 to 71 in 2020. The average age of death increased from 33.6 years in 2018 to 38.2 years in 2021. Over two thirds of deceased (70.9%) had complete secondary or vocational secondary level of education, almost one third (30.0%) were skilled workers, and slightly less than half (44.1%) were unemployed. The most common causes of death were methadone poisoning (34.5%), poisoning with other opioids (21.8%), other synthetic drugs (17.3%), other unspecified drugs (11.8%), and psychostimulants (10.0%). Alcohol intoxication was identified as a concomitant cause of death in every fourth case (26.0%), of which 98% were among males. Most often, alcohol was present in the blood at a concentration of 120 mg/ml and above. Every fourth deceased (23.6%) was registered with narcology health service for drug addiction.

Conclusions

Fatal poisonings with narcotic drugs and psychotropic substances is a growing public health problem in a northern industrial region of Russia, which affects predominantly working-age males and requires comprehensive multisectoral response.

Disclosure

No significant relationships.
What have we Learnt from the UK Triannual Case Reviews about the Role of Parental Mental Illness in Serious Abuse Related Harm of Young Children?
Authors: Wieck A.
Published: September 2022

Up to one in four young children have been estimated to be exposed to parental mental illness. Although the majority of affected parents will not harm their children, is is now well established that parental mental illness places children at an increased risk of all types of injury. Both maternal and paternal mental illness are implicated. Children of parents with mental illness are at the greatest excess risk of being injured in their first year of life, and this applies particularly to violence related harm. Within the first year, the risk is highest during the first three months after birth. A number of parental and family background factors have been identified in the UK triannual serious case reviews of abuse related harm to children and in other publications that can increase or decrease the risk. These findings have significant implications for clinical practice. In order to mitigate the risks to young children, an early assessment of a parent with a mental illlness, close collaboration between mental health, social care and other involved professionals, and a comprehensive care package which aims to improve parental mental health health, reduce other risk factors and exploit parental strengths and protective social factors, are essential. Mental health professionals have an important role to play in achieving improved outcomes for children at risk and their families.

Disclosure

No significant relationships.
Evaluation of the factor structure of the Russian version of PID-5-BF
Authors: Zinchuk M. , Kustov G. , Gersamija A. , Yakovlev A. , Pashnin E. , Voinova N. , Popova S. , Guekht A.
Published: September 2022

Introduction

Traditional categorical classifications of personality disorders (PD) have been criticized for insufficient structural and cross-cultural validity. In the DSM-5 Section III, alternative model of the PDs (AMPD), the maladaptive personality traits are divided into five domains: negative affect, detachment, antagonism, disinhibition and psychoticism. The Personality Inventory for DSM-5 Brief Form (PID-5-BF) is a 25-item self-report questionnaire that measures the severity of each of these five domains. To date, no questionnaires assessing pathological personality traits following the AMPD have been validated in Russia.

Objectives

This study aimed to investigate the factor structure of the Russian version of PID-5-BF.

Methods

Five hundred and 86 (female - 505 (86,2%), age - 18–77 years (M - 28.2, SD - 11.5)) consecutive inpatients with non-psychotic mental disorders were assessed with the Russian language version of the PID-5-BF. Exploratory structural equation modelling (ESEM) with Robust Diagonally Weighted Least Squares method of extraction and Robust Equamax rotation was performed in Factor v 11.04.02.

Results

The results of the ESEM analysis showed good fit of the five-factor model (CFI - 0.982; TLI - 0.971; RMSEA (95% CI) - 0.036 (0.01-0.05). Most of the items had the highest factor loadings on their mother domains. However, two items showed weak loadings on their designated factors (<0.4), and attention seeking item had a primary load to (low) detachment instead of antagonism.

Conclusions

The PID-5-BF was found to be a valid and reliable tool for the evaluation of the AMPD trait domain

Disclosure

No significant relationships.
Phonemic fluency in post-ICU patients after severe COVID-19 infection: The role of cognitive reserve
Authors: Segú X. , Primé Tous M. , Sanchez M. , Valdesoiro F. , Rodriguez A. , Martín I. , Costas A.
Published: September 2022

Introduction

Cognitive function may be impaired in COVID-19 patients, especially in executive functions such as phonemic fluency. Among risk factors, inflammation during hospitalization is related with worse cognitive performance in the long term. On the other side, it has been shown that cognitive reserve (CR) protects against cognitive impairment associated with brain damage, psychiatric disorders and neurodegenerative diseases.

Objectives

Our aim is to study the protective role of cognitive reserve in phonemic fluency to inflammation after SARS-CoV-2 infection.

Methods

We enrolled a cohort of 102 severe SARS-CoV-2 survivors after Intensive Care Unit (ICU) discharge and 58 agreed to participate in this 6-month follow-up study. Patients with previously known cognitive impairment were excluded. Demographic, clinical and laboratory data were collected. To assess the phonemic fluency, we used the Controlled Oral Word Association Test (COWAT) controlling the effects of age and education. Inflammation was recorded according to the number of days with high CRP. ANCOVA analyses were used to test the effect of interaction between medical variables and cognitive reserve on phonemic fluency.

Results

The COVID-19 inflammation interacted with CR in phonemic fluency (F= 6.47, p= 0.01), with worse performance in patients with low CR (mean 16.7 (10.2-23.3)) than those with high CR (mean 37.7 (34.3-41.2)) in function of number of days with high PCR during ICU stay.

Conclusions

The role of the cognitive reserve is important to reduce the cognitive impairment related with COVID-19 inflammation in post-ICU patients.

Disclosure

No significant relationships.
Predictors of Therapy Outcome in Eating Disorders: from Psychopathology to Personality
Authors: Fernandez-Aranda F. , Jimenez-Murcia S. , Granero R.
Published: September 2022

Eating disorders are severe mental disorders, with high mortality rates and high incidence in adolescence and early adulthood, especially in women. The course of these disorders is uncertain and treatment outcomes are limited. Several factors such as duration of the disorder, dysfunctional personality traits and cognitive profiles, as well as genetic vulnerabilities, will influence adherence and response to treatment. In this presentation we will include recent results on prospective observational studies, analyzing personality and cognitive predictors of treatment response in eating disorders, as well as potential associated neurobiomarkers.

Disclosure

FFA received consultancy honoraria from Novo Nordisk and editorial honoraria as EIC from Wiley. The rest of the authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of
The image of a healthcare specialist on social media during the COVID-19 pandemic as a factor in the psychological stability of Internet users
Authors: Shaigerova L. , Zinchenko Y. , Vakhantseva O.
Published: September 2022

Introduction

As publications on social media have become an important regulator of group opinions, moods and psychological well-being during the spread of COVID-19, it seems necessary to study the contribution of various information as a source of preserving the psychological resources of the population.

Objectives

To analyze the content in communities created during the spread of the COVID-19 pandemic in order to assess the image of health professionals on social media.

Methods

Using datamining methods, we analyzed publications about medical staff in a large community ‘StopCoronavirus.RF’ which unites more than 400 thousand users.

Results

More than 700 thousand entries were ‘liked’ in the community from March 2020 to March 2021; more than 125000 thousand posts were shared, about 290 thousand comments were written, and all community publications were viewed more than 3 billion times. Publications about medical staff working in the ‘red zones’ in Russia are distinguished by the largest number of ‘likes’ (more than 5000) and comments (more than 300). In the publications and comments, the model of modern heroes saving human lives is emphasized. This type of information contributes to the reduction of anxiety and promotion of psychological safety in case of COVID-19 contraction through establishing confidence in the competence of medical staff and their involvement in the fight against the pandemic.

Conclusions

These results suggest that the image of a doctor on social media during the pandemic has acquired special value for the population. Publications on the work of medical staff in the ‘red zones’ help to cope with anxiety associated with the COVID-19 pandemic. The study was funded by RFBR, project number 20-04-60174.

Disclosure

No significant relationships.
Mental health service requirements after hospitalization due to COVID-19: a 1- year follow-up study
Authors: Andreo Jover J. , Vidal-Villegas M.P. , Mediavilla R. , Louzao Rojas I. , Cebolla Lorenzo S. , Fernández Jiménez E. , Muñoz-Sanjosé A. , Bravo-Ortiz M.F. , Martinez-Ales G. , Bayón-Pérez C.
Published: September 2022

Introduction

Long-term COVID-19 effects has been recently described as persistent and prolonged symptoms after an acute and severe SARS-COV-2 (1). An important concern is that the sequelae of severe COVID-19 may suppose a substantial outpatient 's burden for the specialized services in reopening pandemic phase (2).

Objectives

To describe the frequency of mental health service use in COVID-19 hospitalized patients after discharge and to estimate the costs associated to the post- discharge consultations.

Methods

We used a 1-year follow-up cohort of 1455 COVID-19 inpatients hospitalized in La Paz University Hospital of Madrid, Spain between March 16th and April 15th, 2020. Data were retrieved from Psychiatry Service (PS) electronic health records and we described the frequency of mental health reason for consultation. We used information published by the Madrid health Office to estimate the cost of initial and following appointments.

Results

Our sample consisted of 1,455 patients admitted with a COVID-19 diagnosis between March 16th and April 15th, 2020, and then discharged. Roughly half of them were men (776, 53%), 238 (16%) had a prior history of mental health problems, and 44 (3%) died. 193 participants (13%) visited the mental health department after being discharged. The total cost was estimated in 103,581 USD, of which two-thirds corresponded to patients with prior history of mental health problems.

Conclusions

Our results indicate that the mental health burden of severe COVID-19 inpatient s after discharge was substantial during the first year of follow-up. This generate important economic impact to mental health providers and society at large.

Disclosure

No significant relationships.
Anxiety Disorders in the Perinatal Period
Authors: Mcdonald L.
Published: September 2022

Anxiety disorders are common in pregnancy and in the post-natal period. This presentation will focus on how anxiety disorders may present in the perinatal period, the need for accurate and timely diagnosis, and barriers to diagnosis and barriers for women in accessing appropriate care and treatment.

Disclosure

No significant relationships.
Benefits of treadmill training for patients with Down Syndrome
Authors: Kamińska K. , Ciołek M. , Krysta K.
Published: September 2022

Introduction

Down syndrome (DS) is a complex condition that causes various health problems and it is accepted that treadmill training is a therapy method for some of them.

Objectives

The objective was to evaluate the effectiveness of various results of treadmill training in children and adults with DS.

Methods

We included studies in which participants with DS from every age group received treadmill training, alone or combined with physiotherapy and could optionally be compared to a control group with patients with DS who did not use treadmill training. The search was conducted in medical databases: PubMed, PEDro, Science Direct, Scopus and Web of Science and involved trials published until July 2021. Following PRISMA criteria, the Risk of Bias assessment was conducted using a tool developed by the Cochrane Collaboration for RCT. The included studies presented multiple outcomes and various methodologies therefore we were not able to conduct any sort of data synthesis, we presented measures of treatment effect as mean differences and corresponding 95% confidence intervals.

Results

5 studies with a total number of 687 participants were included. 10 trials reported on walking onset, 8 on gait parameters or cardiovascular functions, 4 on anti-inflammatory effect and 3 on executive or cognitive functions. We came across 25 different outcomes in different age groups which are presented in a narrative manner. In all outcomes we have observed a positive result favouring the treadmill training.

Conclusions

Introducing treadmill exercise into typical physiotherapy generates improvements of mental and physical health of people with DS of all ages.

Disclosure

No significant relationships.
Clinical effects of central antagonist of cholecystokinin-1 receptors GB-115 in patients with Generalized Anxiety Disorder
Authors: Dorofeeva O. , Syunyakov T. , Metlina M. , Ivashkina N.
Published: September 2022

Introduction

The pilot clinical study of GB-115, a new peptide antagonist of central cholecystokinin-1 receptors, revealed that drug was clinically effective in patients with generalized anxiety disorder (GAD) at dose 6 mg daily. Here, we provide results of post-hoc analysis of changes of anxiety and fatigue symptoms to give characterization of its clinical effects in clinically relevant doses.

Objectives

To research the changes of anxiety- and fatigue-related symptoms during GB-115 treatment in patients with generalized anxiety disorder (GAD).

Methods

Patients with GAD without somatic diseases aged 18-55 years were eligible in the study. Patients were prescribed with GB-115 6 mg daily for 21 days. Anxiety and fatigue symptoms were assessed with Hamilton Anxiety Rating Scale (HARS) and Multidimensional Fatigue Inventory (MFI-20). Variables are described as medians and interquartile range (IQR). Pre-post comparisons were performed using the Friedman ANOVA at 2-side p-value <0.05.

Results

25 patients diagnosed with GAD (8 males, 17 females; median [IQR] age: 34 [29.75, 43.0]) included in the analysis. Median [IQR] HARS total score decreased from 22 [20, 24.5] to 19 [16, 20], 13 [10.5, 15.5], 9 [5.5, 11] and 5 [3.5, 8] on the Day 3,7,14 and 21, respectively (χ2=95.07, df=4, p<0.001). Median [IQR] MFI-20 score decreased from 70 [46, 75.5] to 59 [41, 74.5], 52 [37.5, 64.5], 37 [26.5, 63] and 28 [24, 48.5] on the Day 3, 7, 14 and 21, respectively (χ2= 55.41, df=4, p<0.001). None of patients had stimulation-related side effects.

Conclusions

GB-115 action in the treatment of GAD patients is characterized with anxiolytic action with mild psychostimulant properties.

Disclosure

No significant relationships.
The multimodal psychotherapy of the anxiety disorders patients
Authors: Mykhaylov B. , Kudinova O.
Published: September 2022

Introduction

Contemporary anxiety disorders are the main medical problem.

Objectives

On the basis of complex psychopatological, pathopsychological research, were obtained reasons and conditions of formation, psychopathological structure, syndrome peculiarities, emotional disfunctions of patients on episodic paroxismal and generalized anxiety disorders and mixed anxiously depressed disorders.

Methods

The basic method was a group psychotherapy with the elements of rational, positive, suggestive and family psychotherapy. In relation to disfunctions of emotional sphere, CBT was used for the phobic-depressive and anxious-depressive syndroms.

Results

180 anxiety disorders patients were examined, by the stationary course of treatment.Decrease of general level of anxiety and internal anxiety was obtained for most patients. No spontaneous emergence of fear was practically observed. While active interviewing, patients stated that their former worries and fears have lost actuality and apparent emotional colouring become. Considerable reduction of symptomatic of the depressed circle also took place, patients started to feel joy and optimism.

Conclusions

To correct emotional disfunction of patients with episodic paroxismal disorders, generalized anxiety disorders and mixed anxiously depressed disorders, psychotherapeutic correction system is optimal to use, which is built based on stepwise and multimodal principles.

Disclosure

No significant relationships.
Medical residents and COVID-19
Authors: Jomli R. , Jemli H. , Ouali U. , Maktouf A. , Zgueb Y. , Aissa A.
Published: September 2022

Introduction

The covid-19 pandemic is a difficult global phenomenon that causes a lot of anxiety and uncertainty. This situation has involved reactions of fear. Healthcare professionals are necessarily in contact with patients, but may find themselves torn between the duty to care and the duty to protect themselves and their relatives.

Objectives

To assess perceived stress among medical residents in Tunisia

Methods

We conducted a descriptive study among a representative sample of residents working at a teaching hospital in Tunis during the first half of 2021 in different departments. We prepared a questionnaire for the study divided in two parts: socio-demographic data; professional data (function, practice setting); data related to contact with covid-19 patients ; questions on fear of covid-19 contamination and the Perceived stress scale (10items)

Results

Our sample consists of 100 residents in 10 different specialties, including 70 in services with direct contact with Covid-19 patients. Stress management is rated good for 30 residents, average for 40 residents and poor for 30 residents. This management depends on the number of guards, the number of patients examined, the technical platform available and especially the period of the pandemic.

Conclusions

Medical residents are in the front line in university hospitals in tunisia. The stress to which they are subjected depends on the working conditions and coping skills of each of them.

Disclosure

No significant relationships.
Cognitive function in female patients with chronic functional constipation
Authors: Morozova M. , Rupchev G. , Alexeev A. , Beniashvili A. , Potanin S. , Burminskiy D. , Lepilkina T.
Published: September 2022

Introduction

Chronic functional gastro-intestinal disorders can affect cognitive functioning of patients (1). Wong et al (2) showed attentional and executive function impairment, Aizawa et al. (3) found impairment of cognitive plasticity and activity of frontal and temporal arias of brain during performing tests in these patients.

Objectives

Assessing of cognitive functioning of the female patients with chronic functional constipation.

Methods

42 Rome IV adult female patients with chronic functional constipation and 26 adult normative female volunteers were tested with Brief Assessment of Cognition in Schizophrenia (BACS).

Results

Both groups were comparable by age (patients’ group 29,5±6,1, volunteers’ group 28,5±9,6, ns) In both groups subjects demonstrated normal level of cognitive functioning but the scores of the patients were closer to the lower level than the scores of the volunteers. The difference was significant in composite scores and in several other scores (Tab.1). Table1.BACSPatients (n=42)Volunteers (n=26)p-levelVerbal Memory49,5± 10,658,8± 7,10,0002Work memory48,2±10,151,7±8,4nsMotor token51,3±10,559,8±10,40,003Verbal fluency52,1±11,556,5±9,9nsSymbol coding45,1±8,454,8±12,70,015Tower of London (planning)50,2±10,757,6±10,20,015Composite scores49,1 ±10,159,9 ±7,40,0001

Conclusions

The findings of the study once more indicate some link between gastrointestinal dysfunction and cognitive functioning. Even these slight decrease in some aspects of cognition from normal population could have negative impact on everyday functioning. The origin of this link is still under question.

Disclosure

No significant relationships.
Thyroid Function Rather Than Thyroid Antibodies Affects Pregnancy and Perinatal Outcomes: Results of a Prospective Study
Authors: Orsolini Francesca , Gianetti Elena , Terrenzio Chiara , Montanelli Lucia , Benelli Elena , Bagattini Brunella , Fiore Emilio , Tonacchera Massimo
Published: September 2022

Context

Thyroid autoantibody positivity has been associated with an increased rate of obstetrical complications.

Objective

We aimed to evaluate the role of thyroid autoantibodies in adverse pregnancy outcomes.

Methods

This prospective study was conducted in the Endocrinology Unit of Pisa Hospital. A total of 975 pregnant women were studied from 2012 to 2021; 572 (59%) were diagnosed with autoimmune thyroid (AT) diseases; 403 (41%) served as controls. Levothyroxine (LT4) treatment was introduced when TSH was > 2.5 mIU/L in the AT group and when TSH was > 4 mIU/L in the controls. Rates of obstetrical complications in each group were measured.

Results

Although the frequency of miscarriage in the AT group was greater (4.8%) than in the controls (2.9%), no significant differences were detected (P = 0.181). There were no differences between the 2 groups concerning the other pregnancy complications, and no association with the titer of thyroid antibodies was observed. The frequency of congenital malformations was greater in the AT group than in the controls (P = 0.019), but no correlation with major congenital malformations was detected (P = 0.872). Given that thyroid hormone concentrations were strictly controlled in our population, we documented a tendency (not significant) toward an increase in miscarriage and preterm birth among women with TSH > 4 mIU/L.

Conclusion

If thyroid function is adequately controlled, the presence and titer of thyroid autoantibodies does not negatively influence gestation. Although not significant, suboptimal thyroid hormone status seems to affect pregnancy outcomes more than thyroid autoimmunity.
The atypical small GTPase RABL3 interacts with RAB11 to regulate early ciliogenesis in human cells
Authors: Kobayashi Tetsuo , Ikeda Tatsuya , Ota Reo , Yasukawa Takafumi , Itoh Hiroshi
Published: September 2022

Primary cilia are near-ubiquitously assembled on cells in the human body, and are broadly associated with genetic diseases and cancers. In the early stage of ciliogenesis, the ciliary vesicle (CV) is formed on the mother centriole, which nucleates the primary cilium. However, the regulatory mechanisms underlying CV formation have not yet been fully elucidated. Here, we found that the atypical small GTPase RAB-like 3 (RABL3) is necessary to assemble primary cilia in human cells. RABL3 directly interacts with RAB11 (herein referring to both RAB11A and RAB11B), which is involved in CV formation. RABL3 localizes around the centrosome during early ciliogenesis, reminiscent of RAB11 dynamics. Furthermore, RABL3 positively controls the CV formation like RAB11. These findings suggest that RABL3 plays an important role, in cooperation with RAB11, in CV formation during early ciliogenesis.
Spatial variability of atmospheric pollutants in the Greater Athens Area using remote sensing techniques
Authors: Γρατσέα Μυρτώ
Published: September 2022

Οι δυσμενείς επιπτώσεις της αστικής ατμοσφαιρικής ρύπανσης στην υγεία σε μεγάλο ποσοστό του παγκόσμιου πληθυσμού που ζει σε αστικά περιβάλλοντα, σε συνδυασμό με τις κλιματικές επιπτώσεις της ατμοσφαιρικής ρύπανσης, καθιστούν αναγκαία τη συνεχή, χαμηλού κόστους παρακολούθηση της ποιότητας της ατμόσφαιρας. Η παρούσα διατριβή επικεντρώνεται στην εφαρμογή επίγειων μεθόδων τηλεπισκόπησης για τη μελέτη της χωροχρονικής κατανομής ατμοσφαιρικών ρύπων στο λεκανοπέδιο της Αττικής και έχει βασιστεί κατά κύριο λόγο στη διαφορική οπτική φασματοσκοπία απορρόφησης (DOAS-Differential Optical Absorption Spectroscopy) διάχυτης ηλιακής ακτινοβολίας. Η συγκεκριμένη τεχνική βασίζεται στις μοριακές δομές απορρόφησης στο ορατό και εγγύς υπεριώδες του ηλεκτρομαγνητικού φάσματος. Οι αέριοι ρύποι που μελετήθηκαν στα πλαίσια της εργασίας με το σύστημα DOAS πολλαπλών διευθύνσεων (Multi Axis, MAX-DOAS) είναι το διοξείδιο του αζώτου (ΝΟ2), η φορμαλδεϋδη (HCHO) και η γλυοξάλη (CHOCHO). Έγινε επίσης υπολογισμός της κατακόρυφης κατανομής των αιωρούμενων σωματιδίων με χρήση αλγορίθμου και μετρήσεις διμερούς του οξυγόνου (Ο4), καθώς και εκτίμηση της αξιοπιστίας των υπολογισμών αυτών μέσω σύγκρισής τους με αντίστοιχα αποτελέσματα συστήματος lidar και ηλιακού φωτομέτρου. Συνολικά, δείχθηκε ότι το επίγειο σύστημα MAX-DOAS είναι ικανό να παρέχει αυτόνομες μετρήσεις ρουτίνας για τη μελέτη της χωροχρονικής κατανομής αερολυμάτων και αερίων ρύπων που επηρεάζουν την αστική φωτοχημεία.Τέλος, διερευνήθηκε η επίδραση της οικονομικής κρίσης των τελευταίων ετών στα επίπεδα της αστικής ρύπανσης: μελετήθηκε η επίπτωση της μειωμένης χρήσης ορυκτών καυσίμων και η παράλληλη αύξηση της χρήσης βιομάζας σε μακροχρόνιες μετρήσεις μονοξειδίου του άνθρακα (CO) σε συνδυασμό με μετρήσεις μαύρου άνθρακα.
Προοπτική ακαδημαϊκής εξέλιξης παιδιού με γενικές μαθησιακές δυσκολίες στην Ελλάδα: Μια μελέτη περίπτωσης βασισμένη σε επικοινωνιακές διδακτικές πρακτικές
Authors: Σταμάτης Παναγιώτης
Published: September 2022

Οι μαθησιακές δυσκολίες αποτελούν ενδιαφέρον θέμα για τους δασκάλους και τους γονείς Αυτό οφείλεται αφενός στο γεγονός ότι εμφανίζονται, ολοένα και περισσότερο με μεγαλύτερη συχνότητα, στο σχολείο και αφετέρου, στη δημιουργία μεγάλων εντάσεων κατά τη «διδασκαλία κατ’ οίκον», όπου οι γονείς καλούνται επιτακτικά να «φροντίσουν» το παιδί τους. Η παρούσα μελέτη επικεντρώνεται στις Γενικές Μαθησιακές Αναπηρίες (ΓΜΔ), επισημαίνοντας τη σύγχρονη παιδαγωγική αντιμετώπιση του ζητήματος από το ελληνικό κράτος σε σχέση με θέματα νομοθεσίας, διδασκαλίας, παροχής κατάλληλου διδακτικού υλικού και διορισμού εξειδικευμένων εκπαιδευτικών. Επίσης, λαμβάνοντας υπόψη το πλαίσιο των διαδικασιών αξιολόγησης των παιδιών με ΓΜΔ, επισημαίνεται ότι το κράτος οφείλει να ενεργεί με αίσθημα ισότιμης μεταχείρισης και δικαιοσύνης, υποστηρίζοντας τα παιδιά με ΓΜΔ στην επίπονη και άνιση προσπάθειά τους να εισαχθούν στην τριτοβάθμια εκπαίδευση, όπως συμβαίνει με τις ομάδες μαθητών με ειδικές μαθησιακές δυσκολίες. Επιπλέον, εστιάζοντας σε μια μελέτη περίπτωσης μαθητή με ΓΜΔ, προτείνονται καλές πρακτικές μέσω τεχνικών διδακτικής επικοινωνίας για την προετοιμασία του σε πανελλαδικές εξετάσεις.
Metre and Semantics in the Poetry of Czech Post-Symbolists Accessed via LDA Topic Modelling
Authors: Plecháč Petr , Kolár Robert
Published: September 2022

The article deals with the relationship between semantics and poetic meter in the works of Czech post-symbolist poets and their predecessors. We access the phenomena by means of a machine-driven meter recognition on one hand and LDA topic modelling on the other. We first show how the poetic groups differ in their general preferences for particular topics. Next we analyze the topic distributions in two dominant metres (i.e. iamb and trochee) across the poetic groups.
Comparative Description of Meters in Thai and Burmese Poetries
Authors: Sarkisov Ivan
Published: September 2022

The article analyzes and classifies the meters used in Thai and Burmese poetry. Though both poetic traditions have a rich literary heritage and an advanced repertoire of poetic meters, their structural properties have not received significant scholarly attention. Along with summarizing preexisting scholarly research on the subject, the article provides description of meters used in traditional Thai poetry and their typological classification. The analysis of meters in Burmese poetry is based on the 18th century long drama “Maniket” by Padethayaza as well as on a collection of short Burmese classical poems. The article describes and classifies the five meters of Thai classical poetry (klon, chan, khlong, kap and rai). Burmese traditional poetry used one or two syllabic meters as well as other meters, which have not yet been classified in the scholarly literature. The article concludes with a comparative analysis of rhyme in Thai and Burmese poetry.
Frutos Rojos en la Era Global: Temporalidad, Migración e Inestabilidad.
Authors: Castillero-Quesada Soledad
Published: September 2022

El siguiente artículo analiza las relaciones socio-labores que tiene lugar en la producción intensiva de frutos rojos en la provincia de Huelva. Por frutos rojos entendemos el cultivo de fresa, frambuesa, arándano y mora. Desde que en la década de los años 80 el cultivo comenzase a expandirse e intensificarse, los modos de relación con la tierra, las condiciones laborales, sociales, ecológicas y políticas han modificado el cultivo hasta encontrar hoy más de 11.000 hectáreas trabajadas en su mayoría por mano de obra extranjera. A través de una metodología etnográfica de corte cualitativa, mediante la observación participante y entrevistas en profundidad realizadas a agricultores, trabajadoras, trabajadores y colectivos, encontramos que a medida que el cultivo ha ido creciendo no se han mejorado los espacios de trabajo. Se muestra como ante esta situación las y los trabajadores han construido distintas estrategias de acción para poder llevar a cabo planes de mejora dentro de este enclave productivo.
The Potential Benefits of Water Reallocation among Agricultural Users.
Authors: Sisto Nicholas , Severinov Sergei
Published: September 2022

Irrigated fields produce a large share of the world’s crops, but in many river basins agriculture faces growing competition from other water users. This paper focuses on the intensity of irrigation water use, i.e., the volume of water applied per unit of irrigated land, in the ten irrigation districts located on the Mexican side of the Rio Grande-Bravo Basin. Based on the analysis of historical production data for the districts’ main crops, results show that irrigation intensity varies widely among the districts and through time. Local environmental conditions (aridity and seasonal availability of water) explain most of this variability; however, districtlevel organizational characteristics (plot sizes and the land tenure regime) also play a role. These features of agricultural water use within the water-stressed river basin point to substantial opportunities for using water transfers to meet nonagricultural water needs (including environmental uses) without affecting overall crop production.
Justicia Social Laboral en el Trabajo Agrícola en Honduras.
Authors: Rivera-Licona César-Stuardo
Published: September 2022

La erradicación de la pobreza solo es posible mediante empleos decentes. Casi 2.200 millones de personas viven por debajo del umbral de pobreza de 2 dólares estadounidenses, aunque los estados se han planteado como objetivos para 2030 erradicar las principales causas, entre ellas la precariedad laboral, los resultados indican que no se podrán alcanzar para 2030 a menos que se establezcan políticas integrales. El trabajo decente descansa sobre la justicia social laboral, que es el valor jurídico que versa sobre las relaciones entre el trabajador-patrono, sus deberes,derechos, las condiciones necesarias para el desempeño adecuado y eficiente del trabajador, sin sacrificar otros ámbitos de su vida. Como valor juridificado permite la crítica al derecho positivo, orientar la creación, interpretación y aplicación de las normas. Se analizó la organización del trabajo y la empresa agrícola en comunicación con el valor de justicia social laboral positivado en Honduras recurriendo a la modelación teórica de la organización del trabajo agrícola, para extrapolar su relación con el equilibrio jurídico de los factores. Concluyéndose que no considerar la empresa agrícola como un nuevo actor en las relaciones de trabajo favorece la precarización laboral.
Polyethene Glycol (PEG-400): An Efficient and Eco-friendly Catalyst For The Preparation of N-benzylideneaniline by Schiff base Reaction
Authors: P. Jindal P. Jindal , P. Kumar P. Kumar , U. Sharma U. Sharma , Chauhan M.S.
Published: September 2022

Schiff base compounds are gaining importance daily in this scenario due to their various biological and catalytic activities. In this study, an efficient and eco-friendly synthesis of N-benzylideneaniline was carried out in polyethene glycol (PEG-400) as a greener medium at room temperature. PEG400 was inexpensive and non-toxic, providing a high yield and efficient medium for the synthesis of Schiff bases with excellent outcomes. Furthermore, FT-IR spectroscopy is used to characterize the newly created Schiff base. The recyclability of the catalyst was also studied up to six cycles.