bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S2 from Establishment and Genetic Landscape of Precancer Cell Model Systems from the Head and Neck Mucosal Lining
Authors: de Boer D. Vicky , Brink Arjen , Buijze Marijke , Stigter-van Walsum Marijke , Hunter Keith D. , Ylstra Bauke , Bloemena Elisabeth , Leemans C. René , Brakenhoff Ruud H.
Published: April 2023

Frequency plots of CNAs detected in tumor and precancer samples. (A) A frequency plot of the 22 tumor cell lines. Note that almost all samples contained a loss at chromosome 3p and a gain at 3q. (B) The same plot was made for 12 precancer cultures originating from the margins, including VU-preSCC-M3 (HN439-M1 was excluded). Although the number of samples is low, there is a clear peak visible at chromosome 9p, where CDKN2A is located. (C) A similar plot was made for the five (erythro)leukoplakia cultures. Again the numbers are low, but a trend towards HNSCC-associated CNAs is clearly visible. All graphs represent the frequency of losses and gains in the group of samples, where blue represent gains and red losses.
Supplementary Table 5 from A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes
Authors: Krishnan Neeraja M. , Dhas Kunal , Nair Jayalakshmi , Palve Vinayak , Bagwan Jamir , Siddappa Gangotri , Suresh Amritha , Kekatpure Vikram D. , Kuriakose Moni Abraham , Panda Binay
Published: April 2023

Aggregate score and individal component-wise scores for all random forest analyses
Supplementary Table 3 from A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes
Authors: Krishnan Neeraja M. , Dhas Kunal , Nair Jayalakshmi , Palve Vinayak , Bagwan Jamir , Siddappa Gangotri , Suresh Amritha , Kekatpure Vikram D. , Kuriakose Moni Abraham , Panda Binay
Published: April 2023

Correlation between rankings of pre- and post-FDR corrected variable importances.
Confirmation of internalized exosomes using confocal microscopy from Exosomes from HNSCC Promote Angiogenesis through Reprogramming of Endothelial Cells
Authors: Ludwig Nils , Yerneni Saigopalakrishna S. , Razzo Beatrice M. , Whiteside Theresa L.
Published: April 2023

Movie 1 - see supplemental data
Supplementary Table 4 from Targeting TAZ-Driven Human Breast Cancer by Inhibiting a SKP2-p27 Signaling Axis
Authors: Shen He , Yang Nuo , Truskinovsky Alexander , Chen Yanmin , Mussell Ashley L. , Nowak Norma J. , Kobzik Lester , Frangou Costa , Zhang Jianmin
Published: April 2023

Correlation analysis between TAZ and FIN genes using TCGA datasets.
Supplementary Spreadsheet S5 from p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes
Authors: Pappas Kyrie , Xu Jia , Zairis Sakellarios , Resnick-Silverman Lois , Abate Francesco , Steinbach Nicole , Ozturk Sait , Saal Lao H. , Su Tao , Cheung Pamela , Schmidt Hank , Aaronson Stuart , Hibshoosh Hanina , Manfredi James , Rabadan Raul , Parsons Ramon
Published: April 2023

List of genes amplified at a frequency of 0.5% or greater in all cancer types in TCGA (used in GSEA). Acronyms for cancer types are expanded in the Materials and Methods.
Supplementary Spreadsheet S3 from p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes
Authors: Pappas Kyrie , Xu Jia , Zairis Sakellarios , Resnick-Silverman Lois , Abate Francesco , Steinbach Nicole , Ozturk Sait , Saal Lao H. , Su Tao , Cheung Pamela , Schmidt Hank , Aaronson Stuart , Hibshoosh Hanina , Manfredi James , Rabadan Raul , Parsons Ramon
Published: April 2023

List of tumor suppressor genes and oncogenes derived from the gene classifications of the Cancer Gene Census in COSMIC (used in GSEA). Spreadsheet shows gene name and classification (tumor suppressor gene or oncogene).
Figure S6 from Targeting TAZ-Driven Human Breast Cancer by Inhibiting a SKP2-p27 Signaling Axis
Authors: Shen He , Yang Nuo , Truskinovsky Alexander , Chen Yanmin , Mussell Ashley L. , Nowak Norma J. , Kobzik Lester , Frangou Costa , Zhang Jianmin
Published: April 2023

TAZ and SKP2 mRNA expression decreases in response to Dox removal.
Figure S5 from Targeting TAZ-Driven Human Breast Cancer by Inhibiting a SKP2-p27 Signaling Axis
Authors: Shen He , Yang Nuo , Truskinovsky Alexander , Chen Yanmin , Mussell Ashley L. , Nowak Norma J. , Kobzik Lester , Frangou Costa , Zhang Jianmin
Published: April 2023

Heatmaps of gene set enrichment analysis (GSEA) of DEGs based on RNA-Seq data in response to short-term (24hr) TAZ inactivation.
Figure S4 from Targeting TAZ-Driven Human Breast Cancer by Inhibiting a SKP2-p27 Signaling Axis
Authors: Shen He , Yang Nuo , Truskinovsky Alexander , Chen Yanmin , Mussell Ashley L. , Nowak Norma J. , Kobzik Lester , Frangou Costa , Zhang Jianmin
Published: April 2023

Meta-analysis of BC oncogene dependency using Project Achilles RNAi datasets.
Supplementary Figures 1-5 from Inhibiting Integrin β8 to Differentiate and Radiosensitize Glioblastoma-Initiating Cells
Authors: Malric Laure , Monferran Sylvie , Delmas Caroline , Arnauduc Florent , Dahan Perrine , Boyrie Sabrina , Deshors Pauline , Lubrano Vincent , Da Mota Dina Ferreira , Gilhodes Julia , Filleron Thomas , Siegfried Aurore , Evrard Solène , Kowalski-Chauvel Aline , Moyal Elizabeth Cohen-Jonathan , Toulas Christine , Lemarié Anthony
Published: April 2023

S1. Phenotypic characterization of GIC-enriched neurospheres and related GDC cultures. S2. Expression of major integrins in GIC compared to GDC. S3. Correlation of ITGB8 and stem/differentiated markers in GB patients from the TCGA database. S4. Immunohistological pattern of ITGβ8 and Sox2 staining. S5. siRNA-mediated ITGβ8 knock-down impairs GIC stemness and induces apoptosis.
Supplementary Data from Inhibiting Integrin β8 to Differentiate and Radiosensitize Glioblastoma-Initiating Cells
Authors: Malric Laure , Monferran Sylvie , Delmas Caroline , Arnauduc Florent , Dahan Perrine , Boyrie Sabrina , Deshors Pauline , Lubrano Vincent , Da Mota Dina Ferreira , Gilhodes Julia , Filleron Thomas , Siegfried Aurore , Evrard Solène , Kowalski-Chauvel Aline , Moyal Elizabeth Cohen-Jonathan , Toulas Christine , Lemarié Anthony
Published: April 2023

"Supplemental materials" Supplemental Table 1: Statistical correlation analysis between expression of ITGB8 and stem or differentiated markers.
Supplemental Fig.S1 - S4 from Atrophied Thymus, a Tumor Reservoir for Harboring Melanoma Cells
Authors: Sizova Olga , Kuriatnikov Denis , Liu Ying , Su Dong-Ming
Published: April 2023

S1. Atrophied thymus, induced by FoxN1 conditional knockout, retains more lymphoma cells than WT mouse normal thymus. S2. Representative flow cytometric dot-plots show Doxorubicin (Doxo) auto-fluorescence in different flow cytometric channels. S3. Co-localization of TAp63 and p21 in the thymic cryosections from mice treated with doxorubicin and PBS, respectively. S4. Potential mechanism by which drug-induced changes in the atrophied thymic microenvironment, subsequently induce thymic-harbored cancer cells with chemo-resistant dormant phenotype.
Figure S5 from AHNAK Loss in Mice Promotes Type II Pneumocyte Hyperplasia and Lung Tumor Development
Authors: Park Jun Won , Kim Il Yong , Choi Ji Won , Lim Hee Jung , Shin Jae Hoon , Kim Yo Na , Lee Seo Hyun , Son Yeri , Sohn Mira , Woo Jong Kyu , Jeong Joseph H. , Lee Cheolju , Bae Yun Soo , Seong Je Kyung
Published: April 2023

The activation of the IGF-1 and EGF signaling pathways in Ahnak-/- lungs.
Supplementary Information from IKKβ-Mediated Resistance to Skin Cancer Development Is Ink4a/Arf-Dependent
Authors: Page Angustias , Bravo Ana , Suarez-Cabrera Cristian , Alameda Josefa P. , Casanova M. Llanos , Lorz Corina , Segrelles Carmen , Segovia José C. , Paramio Jesús M. , Navarro Manuel , Ramirez Angel
Published: April 2023

Legends to Supplementary Figures and supplementary Material and Methods.
Figure S4 from AHNAK Loss in Mice Promotes Type II Pneumocyte Hyperplasia and Lung Tumor Development
Authors: Park Jun Won , Kim Il Yong , Choi Ji Won , Lim Hee Jung , Shin Jae Hoon , Kim Yo Na , Lee Seo Hyun , Son Yeri , Sohn Mira , Woo Jong Kyu , Jeong Joseph H. , Lee Cheolju , Bae Yun Soo , Seong Je Kyung
Published: April 2023

Excessive accumulation of collagen in Ahnak-/- lungs as measured by Masson's trichrome staining.
Figure S2 from AHNAK Loss in Mice Promotes Type II Pneumocyte Hyperplasia and Lung Tumor Development
Authors: Park Jun Won , Kim Il Yong , Choi Ji Won , Lim Hee Jung , Shin Jae Hoon , Kim Yo Na , Lee Seo Hyun , Son Yeri , Sohn Mira , Woo Jong Kyu , Jeong Joseph H. , Lee Cheolju , Bae Yun Soo , Seong Je Kyung
Published: April 2023

Lung weights in Ahnak-/- mice and WT mice at 6, 18, and 40 weeks of age.
Figure S1 from AHNAK Loss in Mice Promotes Type II Pneumocyte Hyperplasia and Lung Tumor Development
Authors: Park Jun Won , Kim Il Yong , Choi Ji Won , Lim Hee Jung , Shin Jae Hoon , Kim Yo Na , Lee Seo Hyun , Son Yeri , Sohn Mira , Woo Jong Kyu , Jeong Joseph H. , Lee Cheolju , Bae Yun Soo , Seong Je Kyung
Published: April 2023

Representative IHC images of lung cancer tissues corresponding to indicated grades for AHNAK expression
Table S4 from Normal and Cancerous Tissues Release Extrachromosomal Circular DNA (eccDNA) into the Circulation
Authors: Kumar Pankaj , Dillon Laura W. , Shibata Yoshiyuki , Jazaeri Amir A. , Jones David R. , Dutta Anindya
Published: April 2023

Table S4: Summary of microDNA sequencing and mapping in paired tumor and normal human lung tissue.
Figure S3 from E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms
Authors: Jolly Mohit Kumar , Ware Kathryn E. , Xu Shengnan , Gilja Shivee , Shetler Samantha , Yang Yanjun , Wang Xueyang , Austin R. Garland , Runyambo Daniella , Hish Alexander J. , Bartholf DeWitt Suzanne , George Jason T. , Kreulen R. Timothy , Boss Mary-Keara , Lazarides Alexander L. , Kerr David L. , Gerber Drew G. , Sivaraj Dharshan , Armstrong Andrew J. , Dewhirst Mark W. , Eward William C. , Levine Herbert , Somarelli Jason A.
Published: April 2023

S3. CREB knockdown indicates it is downstream of E-cadherin and TBX2.
Figure S2 from E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms
Authors: Jolly Mohit Kumar , Ware Kathryn E. , Xu Shengnan , Gilja Shivee , Shetler Samantha , Yang Yanjun , Wang Xueyang , Austin R. Garland , Runyambo Daniella , Hish Alexander J. , Bartholf DeWitt Suzanne , George Jason T. , Kreulen R. Timothy , Boss Mary-Keara , Lazarides Alexander L. , Kerr David L. , Gerber Drew G. , Sivaraj Dharshan , Armstrong Andrew J. , Dewhirst Mark W. , Eward William C. , Levine Herbert , Somarelli Jason A.
Published: April 2023

S2. Ectopic E-cadherin expression in sarcoma cells does not alter EMT.
Supplementary Figure S7 from Potent EMT and CSC Phenotypes Are Induced By Oncostatin-M in Pancreatic Cancer
Authors: Smigiel Jacob M. , Parameswaran Neetha , Jackson Mark W.
Published: April 2023

OSM promotes tumorigenicity even at limiting cell numbers
Figure S3 from De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer
Authors: Jafari Naser , Drury James , Morris Andrew J. , Onono Fredrick O. , Stevens Payton D. , Gao Tianyan , Liu Jinpeng , Wang Chi , Lee Eun Y. , Weiss Heidi L. , Evers B. Mark , Zaytseva Yekaterina Y.
Published: April 2023

Supplemental Figure 3. Inhibition of sphingolipid metabolism limits formation of focal adhesion complexes in primary CRC cells.
Figure S1 from De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer
Authors: Jafari Naser , Drury James , Morris Andrew J. , Onono Fredrick O. , Stevens Payton D. , Gao Tianyan , Liu Jinpeng , Wang Chi , Lee Eun Y. , Weiss Heidi L. , Evers B. Mark , Zaytseva Yekaterina Y.
Published: April 2023

Supplemental Figure 1. Expression of FASN, SPHK1 and SPHK2 in CRC.
Supplementary Figure S1 from Potent EMT and CSC Phenotypes Are Induced By Oncostatin-M in Pancreatic Cancer
Authors: Smigiel Jacob M. , Parameswaran Neetha , Jackson Mark W.
Published: April 2023

OSM & OSMR mRNA levels in pancreatic cancer and normal tissue
Table S9, S10 from Genetic and Epigenetic Determinants of Aggressiveness in Cribriform Carcinoma of the Prostate
Authors: Elfandy Habiba , Armenia Joshua , Pederzoli Filippo , Pullman Eli , Pertega-Gomes Nelma , Schultz Nikolaus , Viswanathan Kartik , Vosoughi Aram , Blattner Mirjam , Stopsack Konrad H. , Zadra Giorgia , Penney Kathryn L. , Mosquera Juan Miguel , Tyekucheva Svitlana , Mucci Lorelei A. , Barbieri Christopher , Loda Massimo
Published: April 2023

Table S9: Differentially methylated CpG islands in invasive cribriform vs Noncribriform; Table S10: mRNA expression of the differentially hypermethylated in cribriform with concomitant reduction of mRNA expression.
Supplementary Data 6 from Abemaciclib Is Effective Against Pancreatic Cancer Cells and Synergizes with HuR and YAP1 Inhibition
Authors: Dhir Teena , Schultz Christopher W. , Jain Aditi , Brown Samantha Z. , Haber Alex , Goetz Austin , Xi Chunhua , Su Gloria H. , Xu Liang , Posey James , Jiang Wei , Yeo Charles J. , Golan Talia , Pishvaian Michael J. , Brody Jonathan R.
Published: April 2023

Supplemental figure 6: (A) Pico Green assay assessing cell viability in Mia PaCa2 HuR CRISPR knock out cells treated with abemaciclib. Assay was performed for 5 days prior to collection. (B) Western blot of Mia PaCa2 HuR CRISPR knock out cells treated with abemaciclib for 3 days and probed for pRb and HuR. Samples were quantified and normalized to untreated parental cell type. (C) Mia PaCa2 HuR CRISPR KO clone validation, both by western demonstrating no HuR product (top) and by Sanger sequencing. Clone 8 has a 476 base pair insertion, and clone 10 has a single base pair deletion in one allele and a two base pair deletion in the other allele, both leading to a frameshift mutation. (D) Pico Green assays in Mia PaCa2 cells assessing cell viability in si negative control, siHuR or siYAP1 transfected cells treated with abemaciclib. Assay was performed for 5 days prior to collection. (E) Western blot in Mia PaCa2 cells of si negative control, siHuR or siYAP1 transfected cells treated with abemaciclib for 3 days. Samples were probed for pRb, cyclin D1, HuR, YAP1 and α-tubulin. Samples were quantified and normalized to untreated si negative control. (F) qPCR results from RNA immunoprecipitation (RIP) and probed for HuR targets cyclin D1, p27 and PIM1 (positive control). Cytoplasmic extraction samples normalized to IgG. Significance is denoted as ***p<0.0001. (G) Pico Green assays in Mia PaCa2 cells assessing growth rate inhibition in si negative control or si cyclin D1 transfected cells treated with abemaciclib. Assay was performed for 5 days prior to collection. (H) Western blot in Mia PaCa2 cells of si negative control or si cyclin D1 transfected cells treated with abemaciclib for 3 days. Samples were probed for pRb, cyclin D1 and α-tubulin. Samples were quantified and normalized to untreated si negative control.
Supplementary Data 5 from Abemaciclib Is Effective Against Pancreatic Cancer Cells and Synergizes with HuR and YAP1 Inhibition
Authors: Dhir Teena , Schultz Christopher W. , Jain Aditi , Brown Samantha Z. , Haber Alex , Goetz Austin , Xi Chunhua , Su Gloria H. , Xu Liang , Posey James , Jiang Wei , Yeo Charles J. , Golan Talia , Pishvaian Michael J. , Brody Jonathan R.
Published: April 2023

Supplemental figure 5: (A) Loewe synergy plots for Mia PaCa2 and Panc-1 cells treated with abemaciclib with 5-florouracil (5-FU) or irinotecan. (B) Percent viability for various combination therapies, in Mia PaCa2 and Panc-1 cells, after treatment with abemaciclib and HuR or YAP1 inhibitors as shown. This is in correspondence to the Loewe synergism graphs shown in Figure 6A-B.
Table S4 from Genetic and Epigenetic Determinants of Aggressiveness in Cribriform Carcinoma of the Prostate
Authors: Elfandy Habiba , Armenia Joshua , Pederzoli Filippo , Pullman Eli , Pertega-Gomes Nelma , Schultz Nikolaus , Viswanathan Kartik , Vosoughi Aram , Blattner Mirjam , Stopsack Konrad H. , Zadra Giorgia , Penney Kathryn L. , Mosquera Juan Miguel , Tyekucheva Svitlana , Mucci Lorelei A. , Barbieri Christopher , Loda Massimo
Published: April 2023

Table S4: Function and effect of aberration of SCNV genes associated with cribriform morphology.
Supplementary Figure 5 from Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation
Authors: Yamaoka Toshimitsu , Ohmori Tohru , Ohba Motoi , Arata Satoru , Murata Yasunori , Kusumoto Sojiro , Ando Koichi , Ishida Hiroo , Ohnishi Tsukasa , Sasaki Yasutsuna
Published: April 2023

Schematic model describing the process by which afatinib-resistant cell lines were generated from PC-9 cells and the predicted resistance mechanisms corresponding to potential treatment strategies.
Supplementary Figure 1 from Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation
Authors: Yamaoka Toshimitsu , Ohmori Tohru , Ohba Motoi , Arata Satoru , Murata Yasunori , Kusumoto Sojiro , Ando Koichi , Ishida Hiroo , Ohnishi Tsukasa , Sasaki Yasutsuna
Published: April 2023

Rociletinib, a third generation EGFR-TKI, inhibits EGFR phosphorylation and downstream signals in AFR3 cells.
Supplemental Figures 1-3 and Supplemental Tables 1-9 from Biomarker Assessment of HR Deficiency, Tumor BRCA1/2 Mutations, and CCNE1 Copy Number in Ovarian Cancer: Associations with Clinical Outcome Following Platinum Monotherapy
Authors: Stronach Euan A. , Paul James , Timms Kirsten M. , Hughes Elisha , Brown Krystal , Neff Christopher , Perry Michael , Gutin Alexander , El-Bahrawy Mona , Steel Jennifer H. , Liu Xinxue , Lewsley Liz-Anne , Siddiqui Nadeem , Gabra Hani , Lanchbury Jerry S. , Brown Robert
Published: April 2023

Supplemental Figure 1. Flow of patients and samples through study Supplemental Figure 2. Receiver operating curve (ROC) for HRD as a predictor of CA125 response in the HGSOC subset. Supplementary Table 1. Clinical characteristics and patient outcome. Supplemental Table 2. Univariate logistic regression analyses of HRD status, tBRCA and CCNE1 as predictors of CA125 response. Supplemental Table 3. Multivariate logistic regression analysis of HRD and clinical factors as predictors of CA125 Complete Response. Supplemental Table 4: Univariate and multivariate logistic regression analyses of HRD status at the predefined threshold of {greater than or equal to}42 and an exploratory threshold of {greater than or equal to}33 as predictors of CA125 response in the HGSOC subset. Supplemental Table 5. Multivariate logistic regression analysis of tBRCA and clinical factors as predictors of CA125 complete response. Supplemental Table 6: Univariate and multivariate Cox PH analyses of PFS and OS for HRD status at the predefined threshold of {greater than or equal to}42 and an exploratory threshold of {greater than or equal to}33 in the HGSOC subset. Supplemental Table 7. Progression-free survival (PFS) and overall survival (OS) according HRD status, tBRCA mutation status, and CCNE1 amplification in the overall cohort (N=250). Supplemental Table 8. Progression-free survival (PFS) and overall survival (OS) according HRD status, tBRCA mutation status, and CCNE1 amplification in the HGSCO subgroup (N=179). Supplemental Table 9. Multivariate Cox PH analyses of HRD, CCNE1 amplification and clinical factors as predictors of PFS and OS.
Supplementary Table S4 from Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences
Authors: Kaymaz Yasin , Oduor Cliff I. , Yu Hongbo , Otieno Juliana A. , Ong'echa John Michael , Moormann Ann M. , Bailey Jeffrey A.
Published: April 2023

All of the putative mutations detected in eBL and sBL tumors.
Supplementary Table S1 from Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences
Authors: Kaymaz Yasin , Oduor Cliff I. , Yu Hongbo , Otieno Juliana A. , Ong'echa John Michael , Moormann Ann M. , Bailey Jeffrey A.
Published: April 2023

Samples in the sequencing set with detailed information.
Supplementary Table S3 from Down-Regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ Cells Increases USF2-Mediated Cell Growth
Authors: Agirre Xabier , Jiménez-Velasco Antonio , San José-Enériz Edurne , Garate Leire , Bandrés Eva , Cordeu Lucia , Aparicio Oscar , Saez Borja , Navarro Germán , Vilas-Zornoza Amaia , Pérez-Roger Ignacio , García-Foncillas Jesús , Torres Antonio , Heiniger Anabel , Calasanz María José , Fortes Puri , Román-Gómez José , Prósper Felipe
Published: April 2023

Supplementary Table S3 from Down-Regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ Cells Increases USF2-Mediated Cell Growth
Supplementary Table S1 from Down-Regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ Cells Increases USF2-Mediated Cell Growth
Authors: Agirre Xabier , Jiménez-Velasco Antonio , San José-Enériz Edurne , Garate Leire , Bandrés Eva , Cordeu Lucia , Aparicio Oscar , Saez Borja , Navarro Germán , Vilas-Zornoza Amaia , Pérez-Roger Ignacio , García-Foncillas Jesús , Torres Antonio , Heiniger Anabel , Calasanz María José , Fortes Puri , Román-Gómez José , Prósper Felipe
Published: April 2023

Supplementary Table S1 from Down-Regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ Cells Increases USF2-Mediated Cell Growth
Supplementary Methods, Figure 1 from Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells
Authors: Huang Wen-Chin , Li Xiangyan , Liu Jian , Lin Jentai , Chung Leland W.K.
Published: April 2023

PDF file - 103KB
Supplementary Figure 1 from TGF-β1 Induces Endothelial Cell Apoptosis by Shifting VEGF Activation of p38MAPK from the Prosurvival p38β to Proapoptotic p38α
Authors: Ferrari Giovanni , Terushkin Vitaly , Wolff Martin J. , Zhang Xiaodong , Valacca Cristina , Poggio Paolo , Pintucci Giuseppe , Mignatti Paolo
Published: April 2023

PDF file - 51K
Supplementary Methods and Materials from Expression of Wnt3 Activates Wnt/β-Catenin Pathway and Promotes EMT-like Phenotype in Trastuzumab-Resistant HER2-Overexpressing Breast Cancer Cells
Authors: Wu Yanyuan , Ginther Charles , Kim Juri , Mosher Nicole , Chung Seyung , Slamon Dennis , Vadgama Jaydutt V.
Published: April 2023

PDF file - 81K
Supplementary Figure 7 from Expression of Wnt3 Activates Wnt/β-Catenin Pathway and Promotes EMT-like Phenotype in Trastuzumab-Resistant HER2-Overexpressing Breast Cancer Cells
Authors: Wu Yanyuan , Ginther Charles , Kim Juri , Mosher Nicole , Chung Seyung , Slamon Dennis , Vadgama Jaydutt V.
Published: April 2023

PDF file - 59K, siRNA knocked down HER3 sensitizes SKBR3/100-8 cell response to trastuzumab-induced cell growth inhibition
Supplementary Figure Legends 1-4 from Vasohibin-2 Expressed in Human Serous Ovarian Adenocarcinoma Accelerates Tumor Growth by Promoting Angiogenesis
Authors: Takahashi Yoshifumi , Koyanagi Takahiro , Suzuki Yasuhiro , Saga Yasushi , Kanomata Naoki , Moriya Takuya , Suzuki Mitsuaki , Sato Yasufumi
Published: April 2023

PDF file - 70K
Supplementary Figure 6 from Expression of Wnt3 Activates Wnt/β-Catenin Pathway and Promotes EMT-like Phenotype in Trastuzumab-Resistant HER2-Overexpressing Breast Cancer Cells
Authors: Wu Yanyuan , Ginther Charles , Kim Juri , Mosher Nicole , Chung Seyung , Slamon Dennis , Vadgama Jaydutt V.
Published: April 2023

PDF file - 43K, siRNA knocked down EGFR in SKBR3/100-8 cells
Supplementary Figure 5 from Expression of Wnt3 Activates Wnt/β-Catenin Pathway and Promotes EMT-like Phenotype in Trastuzumab-Resistant HER2-Overexpressing Breast Cancer Cells
Authors: Wu Yanyuan , Ginther Charles , Kim Juri , Mosher Nicole , Chung Seyung , Slamon Dennis , Vadgama Jaydutt V.
Published: April 2023

PDF file - 221K, E-cadherin and beta-catenin expression in SKBR3 and SKBR3/100-8 cells
Supplementary Figure 3 from Expression of Wnt3 Activates Wnt/β-Catenin Pathway and Promotes EMT-like Phenotype in Trastuzumab-Resistant HER2-Overexpressing Breast Cancer Cells
Authors: Wu Yanyuan , Ginther Charles , Kim Juri , Mosher Nicole , Chung Seyung , Slamon Dennis , Vadgama Jaydutt V.
Published: April 2023

PDF file - 53K, Confirmation of Wnt pathway gene expression by RT-Q-PCR
Supplementary Figure Legend from The ATPase Activity of Reptin Is Required for Its Effects on Tumor Cell Growth and Viability in Hepatocellular Carcinoma
Authors: Grigoletto Aude , Neaud Véronique , Allain-Courtois Nathalie , Lestienne Patrick , Rosenbaum Jean
Published: April 2023

PDF file - 64K
Supplementary Figure 5 from The ATPase Activity of Reptin Is Required for Its Effects on Tumor Cell Growth and Viability in Hepatocellular Carcinoma
Authors: Grigoletto Aude , Neaud Véronique , Allain-Courtois Nathalie , Lestienne Patrick , Rosenbaum Jean
Published: April 2023

PDF file - 37K, Measurement of senescence by counting Senescence-Associated Heterochromatin Foci (SAHF).
Supplemental Figure 4 from DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing
Authors: Diotti Raffaella , Kalan Sampada , Matveyenko Anastasiya , Loayza Diego
Published: April 2023

Supplemental Figure 4. A. IP-TRAP assays showing the precipitation of telomerase activity with antihTERT or anti-FEN1 antibodies, as well as the assays for OBFC1, p68 (POLA2) and POLÃŽÂ± (p180). Both p68 and p180 are positive in this assay, whereas OBFC1 was negative. The arrow points to the internal PCR control in the reaction (telomeraseindependent). The asterix indicates a non-specific band. B. IP-TRAP assay performed on HelaII extract (left lane), and on immunoprecipitated material with p180 rabbit serum (S). Controls include RNase treated lysates, as well as beads only and preimmune (PI) controls as indicated.
Supplemental Figure 2 from DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing
Authors: Diotti Raffaella , Kalan Sampada , Matveyenko Anastasiya , Loayza Diego
Published: April 2023

Supplemental Figure 2. FACS profiles showing DNA content of the synchronized HeLaII at the indicated time points. These correspond to the experiment shown in 3C and 3D.
Supplementary Figure 1 from The ATPase Activity of Reptin Is Required for Its Effects on Tumor Cell Growth and Viability in Hepatocellular Carcinoma
Authors: Grigoletto Aude , Neaud Véronique , Allain-Courtois Nathalie , Lestienne Patrick , Rosenbaum Jean
Published: April 2023

PDF file - 52K, Subcellular localization of Reptin and Reptin mutants.
Supplementary Table 1 from Radiation Survivors: Understanding and Exploiting the Phenotype following Fractionated Radiation Therapy
Authors: Makinde Adeola Y. , John-Aryankalayil Molykutty , Palayoor Sanjeewani T. , Cerna David , Coleman C. Norman
Published: April 2023

PDF file - 69K, Supplementary Table 1. List of top 10 upregulated and downregulated genes 24h after radiation.
Supplementary Figure Legend from Radiation Survivors: Understanding and Exploiting the Phenotype following Fractionated Radiation Therapy
Authors: Makinde Adeola Y. , John-Aryankalayil Molykutty , Palayoor Sanjeewani T. , Cerna David , Coleman C. Norman
Published: April 2023

PDF file - 70K
Supplementary Figure 1 from Radiation Survivors: Understanding and Exploiting the Phenotype following Fractionated Radiation Therapy
Authors: Makinde Adeola Y. , John-Aryankalayil Molykutty , Palayoor Sanjeewani T. , Cerna David , Coleman C. Norman
Published: April 2023

PDF file - 734K, Supplementary Figure 1. Heat map top 20 altered genes 24h after radiation.
Supplementary Figure and Table Legends from RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer
Authors: Griner Erin M. , Dancik Garrett M. , Costello James C. , Owens Charles , Guin Sunny , Edwards Michael G. , Brautigan David L. , Theodorescu Dan
Published: April 2023

Supplementary Figure and Table Legends. Legends for 3 supplemental figures and 2 tables.
Supplementary Figure 3 from RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer
Authors: Griner Erin M. , Dancik Garrett M. , Costello James C. , Owens Charles , Guin Sunny , Edwards Michael G. , Brautigan David L. , Theodorescu Dan
Published: April 2023

Supplementary Figure 3. Depletion of RhoC with a second independent shRNA A. Doubling time for T24T cells expressing shCont or shRhoC-2 was determined by counting cells at 24 h intervals for 96 h. Bargraph shows the mean doubling time{plus minus}s.e. (n=3). *P<0.05. B. Colony formation in soft agar was assessed in T24T cells expressing shCont or shRhoC-2. Bargraph shows the number of colonies formed and is presented as the mean{plus minus}s.e. *P<0.05. 3 independent experiments were performed in triplicate. C. Graph representing incidence of lung colonization upon tail vein injection of T24T cells expressing shControl or shRhoC-2. p=0.66, Fisher's exact test. D. Scatter plot comparing lung burden in animals injected with T24T cells expressing shControl or shRhoC-2 as measured by human DNA-specific qPCR amplification of lung genomic DNA. Mean is indicated. p=0.016, analysis of non-zero values only, Mann Whitney test.
Supplementary Figure 2 from Acquisition of the Metastatic Phenotype Is Accompanied by H2O2-Dependent Activation of the p130Cas Signaling Complex
Authors: Hempel Nadine , Bartling Toni R. , Mian Badar , Melendez J. Andres
Published: April 2023

PDF file - 109K, Loading controls for Cytosolic (GAPDH) and Membrane fractions (EGF-R). Cells were treated as in Figure 3 and the membrane/cytoskeletal fractions obtained as outlined in the methods section.
Supplementary Figure Legend from Anti–IL-20 Monoclonal Antibody Alleviates Inflammation in Oral Cancer and Suppresses Tumor Growth
Authors: Hsu Yu-Hsiang , Wei Chi-Chen , Shieh Dar-Bin , Chan Chien-Hui , Chang Ming-Shi
Published: April 2023

PDF file - 78K
Supplementary Figure 4 from Fibroblast Growth Factor-2 Is an Important Factor that Maintains Cellular Immaturity and Contributes to Aggressiveness of Osteosarcoma
Authors: Shimizu Takatsune , Ishikawa Tomoki , Iwai Sayaka , Ueki Arisa , Sugihara Eiji , Onishi Nobuyuki , Kuninaka Shinji , Miyamoto Takeshi , Toyama Yoshiaki , Ijiri Hiroshi , Mori Hajime , Matsuzaki Yumi , Yaguchi Tomonori , Nishio Hiroshi , Kawakami Yutaka , Ikeda Yasuo , Saya Hideyuki
Published: April 2023

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Supplementary Figure 3 from Targeting Abnormal DNA Repair in Therapy-Resistant Breast Cancers
Authors: Tobin Lisa A. , Robert Carine , Nagaria Pratik , Chumsri Saranya , Twaddell William , Ioffe Olga B. , Greco George E. , Brodie Angela H. , Tomkinson Alan E. , Rassool Feyruz V.
Published: April 2023

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Supplementary Figure 2 from Targeting Abnormal DNA Repair in Therapy-Resistant Breast Cancers
Authors: Tobin Lisa A. , Robert Carine , Nagaria Pratik , Chumsri Saranya , Twaddell William , Ioffe Olga B. , Greco George E. , Brodie Angela H. , Tomkinson Alan E. , Rassool Feyruz V.
Published: April 2023

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Supplementary Figure 4 from New Insight into the SDF-1/CXCR4 Axis in a Breast Carcinoma Model: Hypoxia-Induced Endothelial SDF-1 and Tumor Cell CXCR4 Are Required for Tumor Cell Intravasation
Authors: Jin Fengyan , Brockmeier Ulf , Otterbach Friedrich , Metzen Eric
Published: April 2023

PDF file - 97K, Analysis of human dermal microvascular endothelial cells (HDMEC)
Supplementary Figure 3 from New Insight into the SDF-1/CXCR4 Axis in a Breast Carcinoma Model: Hypoxia-Induced Endothelial SDF-1 and Tumor Cell CXCR4 Are Required for Tumor Cell Intravasation
Authors: Jin Fengyan , Brockmeier Ulf , Otterbach Friedrich , Metzen Eric
Published: April 2023

PDF file - 101K, CXCR4 is induced by hypoxia in MCF7
Supplementary Figure 1 from New Insight into the SDF-1/CXCR4 Axis in a Breast Carcinoma Model: Hypoxia-Induced Endothelial SDF-1 and Tumor Cell CXCR4 Are Required for Tumor Cell Intravasation
Authors: Jin Fengyan , Brockmeier Ulf , Otterbach Friedrich , Metzen Eric
Published: April 2023

PDF file - 64K, Effects of hypoxia on SDF-1 and CXCR4 expression in endothelial cells
Supplementary Figure 1 from PRSS3/Mesotrypsin Is a Therapeutic Target for Metastatic Prostate Cancer
Authors: Hockla Alexandra , Miller Erin , Salameh Moh'd A. , Copland John A. , Radisky Derek C. , Radisky Evette S.
Published: April 2023

PDF file - 226K, Figure demonstrating that silencing of PRSS3 in prostate cancer cells significantly reduced migration
Supplementary Figure Legends 1-7 from Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK Pathways
Authors: Menges Craig W. , Sementino Eleonora , Talarchek Jacqueline , Xu Jinfei , Chernoff Jonathan , Peterson Jeffrey R. , Testa Joseph R.
Published: April 2023

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Supplementary Figure 6 from Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK Pathways
Authors: Menges Craig W. , Sementino Eleonora , Talarchek Jacqueline , Xu Jinfei , Chernoff Jonathan , Peterson Jeffrey R. , Testa Joseph R.
Published: April 2023

PDF file - 196K, Immunoblot analysis of P-PAK1/2/3, total PAK1/2/3, P-AKT, AKT, P-ERK1/2, ERK1/2 and beta actin levels 24-hr post-nucleofection of pcDNA or pcDNA-PID in Me12 cells (left panels); pcDNA and increasing concentrations of pcDNA-PID in Meso 22 cells (right panels)
Supplementary Figure 5 from Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK Pathways
Authors: Menges Craig W. , Sementino Eleonora , Talarchek Jacqueline , Xu Jinfei , Chernoff Jonathan , Peterson Jeffrey R. , Testa Joseph R.
Published: April 2023

PDF file - 18K, MTS assays of ME12 and Meso 22 cells treated with 0, 10, 20, 30, 40, 50, 60 and 70 muM PIR3.5 compound after 72 hours of treatment
Supplementary Tables 1-6 from Molecular Hierarchy of Heparin-Binding EGF-like Growth Factor–Regulated Angiogenesis in Triple-Negative Breast Cancer
Authors: Yotsumoto Fusanori , Tokunaga Eriko , Oki Eiji , Maehara Yoshihiko , Yamada Hiromi , Nakajima Kyoko , Nam Sung Ouk , Miyata Kohei , Koyanagi Midori , Doi Keiko , Shirasawa Senji , Kuroki Masahide , Miyamoto Shingo
Published: April 2023

PDF File - 72K, Sequences of siRNA oligo used in Figure 2A and Supplementary Figure S2A.
Supplementary Figure 3 from Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK Pathways
Authors: Menges Craig W. , Sementino Eleonora , Talarchek Jacqueline , Xu Jinfei , Chernoff Jonathan , Peterson Jeffrey R. , Testa Joseph R.
Published: April 2023

PDF file - 32K, IHC analysis of murine MM tissues with the P-PAK1,2,3 (Ser 141) antibody with and without pre-treatment with lambda phosphatase (lamdaPPtase)
Supplementary Figure 1 from Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK Pathways
Authors: Menges Craig W. , Sementino Eleonora , Talarchek Jacqueline , Xu Jinfei , Chernoff Jonathan , Peterson Jeffrey R. , Testa Joseph R.
Published: April 2023

PDF file - 48K, 2-dimensional immunoblot analysis of PAK1, PAK1/2/3 and P PAK1/2/3 levels in four different human MM cell lines
Figure S2 from Mitochondria Participate in Chemoresistance to Cisplatin in Human Ovarian Cancer Cells
Authors: Zampieri Luca X. , Grasso Debora , Bouzin Caroline , Brusa Davide , Rossignol Rodrigue , Sonveaux Pierre
Published: April 2023

Figure S2 shows that acute cisplatin treatment increases SKOV-3 cell polyploidy.
Supplementary Video 4 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer
Authors: Hu Xiaowen , Guo Jinyi , Zheng Lan , Li Chunsheng , Zheng Tim M. , Tanyi Janos L. , Liang Shun , Benedetto Chiara , Mitidieri Marco , Katsaros Dionyssios , Zhao Xia , Zhang Youcheng , Huang Qihong , Zhang Lin
Published: April 2023

AVI file - 254K, let-7b inhibits breast cancer cell motility�would healing assay.
Supplementary Figure S1(A-D) from Adaptor Molecule Crk Is Required for Sustained Phosphorylation of Grb2-Associated Binder 1 and Hepatocyte Growth Factor–Induced Cell Motility of Human Synovial Sarcoma Cell Lines
Authors: Watanabe Takuya , Tsuda Masumi , Makino Yoshinori , Ichihara Shin , Sawa Hirofumi , Minami Akio , Mochizuki Naoki , Nagashima Kazuo , Tanaka Shinya
Published: April 2023

Supplementary Figure S1(A-D) from Adaptor Molecule Crk Is Required for Sustained Phosphorylation of Grb2-Associated Binder 1 and Hepatocyte Growth Factor–Induced Cell Motility of Human Synovial Sarcoma Cell Lines
Supplementary Figures S1-S4 from A Functional Screen Identifies miR-34a as a Candidate Neuroblastoma Tumor Suppressor Gene
Authors: Cole Kristina A. , Attiyeh Edward F. , Mosse Yael P. , Laquaglia Michael J. , Diskin Sharon J. , Brodeur Garrett M. , Maris John M.
Published: April 2023

Supplementary Figures S1-S4 from A Functional Screen Identifies miR-34a as a Candidate Neuroblastoma Tumor Suppressor Gene
Supplementary Data from The Identification of MicroRNAs in a Genomically Unstable Region of Human Chromosome 8q24
Authors: Huppi Konrad , Volfovsky Natalia , Runfola Timothy , Jones Tamara L. , Mackiewicz Mark , Martin Scott E. , Mushinski J. Frederic , Stephens Robert , Caplen Natasha J.
Published: April 2023

Supplementary Data from The Identification of MicroRNAs in a Genomically Unstable Region of Human Chromosome 8q24
Supplemental Figure S6 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
Authors: Crowe Matthew S. , Zavorotinskaya Tatiana , Voliva Charles F. , Shirley Matthew D. , Wang Yanqun , Ruddy David A. , Rakiec Daniel P. , Engelman Jeffery A. , Stuart Darrin D. , Freeman Alyson K.
Published: April 2023

Supplementary Figure S6 shows loading controls for all Western blot analyses from Figure 5.
Supplemental Figure S5 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
Authors: Crowe Matthew S. , Zavorotinskaya Tatiana , Voliva Charles F. , Shirley Matthew D. , Wang Yanqun , Ruddy David A. , Rakiec Daniel P. , Engelman Jeffery A. , Stuart Darrin D. , Freeman Alyson K.
Published: April 2023

Supplementary Figure S5 shows mRNA microarray data from WM266-4 cells upon knockdown of ERK1 or ERK2 or treatment with MAPK inhibitors as well as detailed analysis of RNAseq data and RT-PCR validation from A375 cells with knockdown of ERK1 or ERK2 or with knockdown of ERK2 and exogenous overexpression of ERK1.
Supplemental Figure S4 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
Authors: Crowe Matthew S. , Zavorotinskaya Tatiana , Voliva Charles F. , Shirley Matthew D. , Wang Yanqun , Ruddy David A. , Rakiec Daniel P. , Engelman Jeffery A. , Stuart Darrin D. , Freeman Alyson K.
Published: April 2023

Supplementary Figure S4 shows Western blot analysis and dose-response effects of ERK inhibition in A375 cells expressing inhibitor-resistant ERK2 with or without additional mutations affecting kinase activity or substrate docking.
Supplementary Movie 2 from SPANX Control of Lamin A/C Modulates Nuclear Architecture and Promotes Melanoma Growth
Authors: Lazar Ikrame , Fabre Bertrand , Feng Yongmei , Khateb Ali , Turko Patrick , Martinez Gomez Julia M. , Frederick Dennie T. , Levesque Mitchell P. , Feld Lea , Zhang Gao , Zhang Tongwu , James Brian , Shklover Jeny , Avitan-Hersh Emily , Livneh Ido , Scortegagna Marzia , Brown Kevin , Larsson Ola , Topisirovic Ivan , Wolfenson Haguy , Herlyn Meenhard , Flaherty Keith , Dummer Reinhard , Ronai Ze'ev A.
Published: April 2023

Supplementary Movie S2 - 3D representation around the X axis of A375 cell nucleus
Figure S5 from p53 Is Not Required for High CIN to Induce Tumor Suppression
Authors: Funk Laura C. , Wan Jun , Ryan Sean D. , Kaur Charanjeet , Sullivan Ruth , Roopra Avtar , Weaver Beth A.
Published: April 2023

Figure S5 shows that high CIN causes cell death due to excessive chromosome loss.
Figure S2 from p53 Is Not Required for High CIN to Induce Tumor Suppression
Authors: Funk Laura C. , Wan Jun , Ryan Sean D. , Kaur Charanjeet , Sullivan Ruth , Roopra Avtar , Weaver Beth A.
Published: April 2023

Figure S2 shows the sex-specific survival advantage of p53 heterozygous male mice is not caused by differences in tumor spectrum.
Supplementary Table 2 from Comprehensive Molecular Profiling of Desmoplastic Small Round Cell Tumor
Authors: Slotkin Emily K. , Bowman Anita S. , Levine Max F. , Dela Cruz Filemon , Coutinho Diego F. , Sanchez Glorymar I. , Rosales Nestor , Modak Shakeel , Tap William D. , Gounder Mrinal M. , Thornton Katherine A. , Bouvier Nancy , You Daoqi , Gundem Gunes , Gerstle Justin T. , Heaton Todd E. , LaQuaglia Michael P. , Wexler Leonard H. , Meyers Paul A. , Kung Andrew L. , Papaemmanuil Elli , Zehir Ahmet , Ladanyi Marc , Shukla Neerav
Published: April 2023

Supplementary Table 2 shows the raw data further described in Figure 3
Supplemental Figure 4 from In Situ Analysis of N-Linked Glycans as Potential Biomarkers of Clinical Course in Human Prostate Cancer
Authors: Conroy Lindsey R. , Stanback Alexandra E. , Young Lyndsay E.A. , Clarke Harrison A. , Austin Grant L. , Liu Jinze , Allison Derek B. , Sun Ramon C.
Published: April 2023

Supplemental Figure 4. N-glycans are further elevated in adjacent benign tissue of Black patient sample.
Supplementary Data S5 from The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
Authors: Smith Kaitlyn H. , Budhraja Amit , Lynch John , Roberts Kathryn , Panetta John C. , Connelly Jon P. , Turnis Meghan E. , Pruett-Miller Shondra M. , Schuetz John D. , Mullighan Charles G. , Opferman Joseph T.
Published: April 2023

HRI activation synergizes with BH3-mimetics in Ph+ and Ph-like ALL cell lines
Figure S2 from TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation
Authors: Kosmas Kosmas , Filippakis Harilaos , Khabibullin Damir , Turkiewicz Michal , Lam Hilaire C. , Yu Jane , Kedersha Nancy L. , Anderson Paul J. , Henske Elizabeth P.
Published: April 2023

Intrinsically disordered regions in TSC2.
Supplementary Figures 1-11 from Suppression of MET Signaling Mediated by Pitavastatin and Capmatinib Inhibits Oral and Esophageal Cancer Cell Growth
Authors: Xu Bo , Muramatsu Tomoki , Inazawa Johji
Published: April 2023

S1. The sensitivity to pitavastatin in OSCC and ESCC cell lines. S2. Pitavastatin suppresses the expression of cell cycle-related genes and induces DNA damage. S3. GGPS1 is a key regulator of cell growth. S4. GGPS1 expression might be correlated with sensitivity to statins. S5. DGBP, a GGPS1 inhibitor, inhibits tumor growth as well as pitavastatin. S6. MET expression is associated with poor prognosis in head and neck cancer. S7. Treatment with pitavastatin or knockdown of GGPS1 inhibited MET maturation. S8. The inhibition of MET maturation is caused by inhibition of the mevalonate pathway. S9. The combination of pitavastatin and capmatinib synergistically inhibits cell growth in vitro. S10. The combination of statins and capmatinib has a synergistic effect on cell growth inhibition. S11. Adding mevalonate or GGPP cancels the effect of the combination of pitavastatin and capmatinib on cell growth, and this combination synergistically enhances tumor growth inhibition in ovo and in vivo mouse models.
Supplementary Figure S5 from A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1
Authors: Wirawan Aditya , Tajima Ken , Takahashi Fumiyuki , Mitsuishi Yoichiro , Winardi Wira , Hidayat Moulid , Hayakawa Daisuke , Matsumoto Naohisa , Izumi Kenta , Asao Tetsuhiko , Ko Ryo , Shimada Naoko , Takamochi Kazuya , Suzuki Kenji , Abe Masaaki , Hino Okio , Sekido Yoshitaka , Takahashi Kazuhisa
Published: April 2023

Supplementary Figure S5 shows role of MFGE8 in MPM.
Supplementary Figure S3 from A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1
Authors: Wirawan Aditya , Tajima Ken , Takahashi Fumiyuki , Mitsuishi Yoichiro , Winardi Wira , Hidayat Moulid , Hayakawa Daisuke , Matsumoto Naohisa , Izumi Kenta , Asao Tetsuhiko , Ko Ryo , Shimada Naoko , Takamochi Kazuya , Suzuki Kenji , Abe Masaaki , Hino Okio , Sekido Yoshitaka , Takahashi Kazuhisa
Published: April 2023

Supplementary Figure S3 shows that LSD1 suppression attenuated the mesenchymal phenotype.
Supplementary Figure Legends from A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1
Authors: Wirawan Aditya , Tajima Ken , Takahashi Fumiyuki , Mitsuishi Yoichiro , Winardi Wira , Hidayat Moulid , Hayakawa Daisuke , Matsumoto Naohisa , Izumi Kenta , Asao Tetsuhiko , Ko Ryo , Shimada Naoko , Takamochi Kazuya , Suzuki Kenji , Abe Masaaki , Hino Okio , Sekido Yoshitaka , Takahashi Kazuhisa
Published: April 2023

Supplementary Figure Legends
Supplementary Figure 1 from SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation
Authors: Adolphe Christelle , Millar Amanda , Kojic Marija , Barkauskas Deborah S. , Sundström Anders , Swartling Fredrik J. , Hediyeh-zadeh Soroor , Tan Chin Wee , Davis Melissa J. , Genovesi Laura A. , Wainwright Brandon J.
Published: April 2023

S1. Sox 9 and Sox 2 immunoreactivity in the developing cerebellum
FigureS1 from Adipokine Apelin/APJ Pathway Promotes Peritoneal Dissemination of Ovarian Cancer Cells by Regulating Lipid Metabolism
Authors: Dogra Samrita , Neelakantan Deepika , Patel Maulin M. , Griesel Beth , Olson Ann , Woo Sukyung
Published: April 2023

Apelin in promoting metastatic phenotypes
Supplementary Figures and Legends 1-5 from Defects in Emerin–Nucleoskeleton Binding Disrupt Nuclear Structure and Promote Breast Cancer Cell Motility and Metastasis
Authors: Liddane Alexandra G. , McNamara Chelsea A. , Campbell Mallory C. , Mercier Isabelle , Holaska James M.
Published: April 2023

S1. Emerin-null myogenic progenitor nuclei are smaller than wild-type myogenic progenitor nuclei. S2. GFP-emerin increases nuclear area in MDA-157 cells. S3. GFP-emerin and GFP-emerin mutants do not affect cell cycle progression or apoptosis. S4. GFP-emerin expression decreases cell migration through 8.0 μm pores. S5. Normal control patient samples from multiple sources have similar emerin protein levels.