bluuebunny/crossref_metadata_2025 huggingface dataset:
SOSIALISASI INFORMASI DAN KOMUNIKASI JAMINAN KESEHATAN BPJS DALAM MENINGKATKAN PELAYANAN KESEHATAN LANSIA
Authors: Dewi Riskha Dora Candra
Published: April 2021

Pendahuluan: Permasalahan lansia tentang BPJS kesehatan yaitu lansia masih belum memahami mengenai cara mendapatkan dan tahapan dalam pengobatan dengan menggunakan BPJS mulai dari rujukan pelayanan kesehatan tingkat pertama ke rujukan pelayanan kesehatan tingkat paling tinggi. Lansia juga belum mendapatkan informasi secara maksimal mengenai jaminan kesehatan BPJS. Metodologi: Metode pemecahan permasalahan dalam pengabdian masyarakat menggunakan edukasi oleh tenaga kesehatan pada lansia. Konsep metode edukasi meliputi: 1) tahap orientasi; 2) kerja; 3) resolusi. Memberikan materi meliputi: 1) pengertian BPJS; 2) jenis-jenis BPJS; 3) pelayanan-pelayanan dalam BPJS; 4) pembayaran iuran BPJS; 5) prosedur pendaftaran BPJS; 6) manfaat BPJS bagi lansia. Hasil: Hasil pengabdian masyarakat memberikan materi tentang BPJS selama 30 menit. Kesimpulan: Kegiatan sosialisasi informasi dan komunikasi jaminan kesehatan BPJS dalam meningkatkan pelayanan kesehatan lansia dapat meningkatkan pola hidup sehat lansia, sehingga lansia tetap produktif dan mendapatkan pelayanan kesehatan yang terpenuhi secara komprehensif dan bertanggung jawab.
OPTIMALISASI PERAN KADER REMAJA MELALUI PELATIHAN DAN DISKUSI INTERAKTIF TENTANG KENAKALAN REMAJA SEBAGAI ANTISIPASI DAMPAK NEGATIF PERKEMBANGAN TEKNOLOGI INFORMASI
Authors: Sumiatin Titik
Published: April 2021

According to various sources, the increase in juvenile delinquency rates is very concerning. Prevention of risky behavior in adolescents is needed, because adolescence was a period where someone was looking for identity. Through Posyandu activities, teenagers have a place to get knowledge about various things, looking for solutions to problems related to health and so on. Based on information from the village midwife who is responsible for the existence and sustainability of the Youth Posyandu in Dawung Village, Palang District, Posyandu activities are increasingly passive. because of the decreasing interest of teenagers to attend every event that was initiated and held. Of the 517 teenagers who were targeted by the Youth Posyandu, only 50 (9.6%) attended the activity every month, And of the 50 teenagers who attended, when invited to discuss, they focused on the cellphone or gadget that was being held. Through this activity the researcher wants to optimize the role of youth cadres through increasing knowledge with training and interactive discussions with youth Posyandu cadres about juvenile delinquency as the impact of negative anticipation of the development of Information technology, as an effort to prevent the increasing risk behavior in adolescents.
Pemeriksaan Kadar Gula Darah, Konseling Tentang Diabetes Mellitus Dengan Komplikasinya Di PSTW Jombang
Authors: - Rodiyah
Published: April 2021

Indonesia merupakan Negara terbanyak ke empat di dunia untuk jumlah penderita terbanyak diabetes mellitus setelah India, Cina dan  Amerika Serika. Diabetes melitus merupakan suatu kumpulan problema anatomik dan kimiawi yang merupakan akibat dari sejumlah faktor. Pasien dengan Diabetus Mellitus biasanya datang ke pelayanan kesehatan dengan komplikasi. Tujuan dari kegiatan ini membantu para Lansia dan masyarakat sekitar panti  untuk dapat  mengetahui kadar gula darahnya dan memberikan konseling tentang diabetes Mellitus di Unit Pelaksana Teknis Pelayanan Sosial Tresna Werdha Jombang. Pada kegiatan ini di dapatkan hasil pemeriksaan kadar gula darah  9 orang (20,5%) dalam kategori bukan DM,  26 orang ( 59%) dalam kategori belum pasti DM, dan 9 orang (20,5%) dalam kategori DM. Berdasarkan hasil dari pemeriksaan kadar gula darah diharapkan lansia dan masyarakat sekitar panti dapat lebih menerapkan pola hidup sehat seperti mengontrol pola makan, melakukan aktivitas fisik sesuai kemampuan dan juga bisa mengontrol kadar gula darahnya dengan pemeriksaan yang teratur. Bagi yang sudah terdeteksi menderita Diabetus mellitus diharapkan untuk selalu memeriksakan diri ke petugas kesehatan minimal 1 bulan sekali.
  
Kata Kunci: Kadar Gula Darah, Konseling Diabetus Mellitus, Komplikasi
Kesadaran Berhenti Merokok Masyarakat di Wilayah Kerja Puskesmas Penawar Jaya Kabupaten Tulang Bawang Tahun 2020
Authors: Sari Puspa , Sary Lolita , Febriani Christin Angelina
Published: April 2021

Penyakit Tidak Menular (PTM) menjadi penyebab kematian terbanyak di seluruh dunia. Hampir 6 juta kematian per tahun disebabkan karena menghisap tembakau. Tujuan penelitian ini untuk mengetahui mengetahui kesadaran berhenti merokok masyarakat di wilayah kerja UPTD Puskesmas Penawar Jaya Kabupaten Tulang Bawang. Jenis penelitian yang digunakan adalah kualitatif dengan pendekatan fenomenologi. Subyek dalam penelitian ini adalah masyarakat yang sudah berhenti merokok di wilayah kerja UPTD Puskesmas Penawar Jaya Kabupaten Tulang Bawang. informan ini terdiri dari 4 orang yaitu 1 orang sebagai informan kunci dan 3 orang sebagai informan. Teknik pengumpulan data menggunakan wawancara mendalam. Hasil penelitian ini menunjukkan bahwa semua informan mengatakan kesadaran berhenti merokok diawali karena menderita penyakit beresiko. Manfaat berhenti merokok adalah badan terasa sehat dan mengurangi pengeluaran. Sebagian kecil informan mengatakan bahwa hambatan berhenti merokok yaitu badan terasa lemas. Cara mengatasi hambatan masyarakat dalam berhenti merokok dengan memberikan konseling. Diharapkan pihak puskesmas dapat terus melakukan dukungan kepada masyarakat yang berupaya berhenti merokok.
Determinan Perilaku Buang Air Besar Sembarangan Pada Masyarakat Daerah Aliran Sungai Desa Anggah Jaya Kabupaten Sintang
Authors: Sunarti Sunarti -
Published: April 2021

Perilaku buang air besar sembarangan (BABS) adalah kondisi ketika setiap individu dalam komunitas buang air besar sembarangan di area terbuka. Tujuan penelitian untuk mengetahui Determinan Perilaku Buang Air Besar Sembarangan Pada Masyarakat Daerah Aliran Sungai Desa Anggah Jaya Kabupaten Sintang. Metode Penelitian ini dengan Crossectional, populasi sebanyak 163 KK dan sampel 62 responden. menggunakan tehnik Proportional  Random Sampling. Analisa data dilakukan dengan uji Chi-Square. Hasil analisa diketahui ada hubungan yang bermakna antara Pengetahuan (p value = 0,020), Sikap (p value = 0,013), Pendidikan (p value = 0,007), Pendapatan (p value = 0,002), Kepemilikan Jamban Keluarga (p value = 0,043) dengan Perilaku Buang Air Besar Sembarangan Pada Masyarakat Daerah Aliran Sungai Desa Anggah Jaya Kabupaten Sintang. Hasil analisis regresi logistik dengan metode backward LR menunjukkan Sikap dengan nilai p=0,064 expB=8,713) dan pendidikan dengan (p=0,0001 expB=124,726), berpengaruh signifikan dengan Perilaku Buang Air Besar Sembarangan Pada Masyarakat Daerah Aliran Sungai Desa Anggah Jaya Kabupaten Sintang. Disarankan kepada masyarakat untuk aktif kerjasama dengan berbagai pihak sehingga dapat membentu dalam pemenuhan sarana penunjang pembuatan jamban sehat.
Efektivitas Pendidikan Kesehatan perhadap Motivasi Diit Hipertensi Pada Lansia Hipertensi di Posyandu Lansia Desa Makarti Tulang Bawang Barat Tahun 2020
Authors: Utari Rita , Sari Nurhalina , Sari Fitri Eka
Published: April 2021

Hipertensi atau biasa disebut “Silent Killer” tanpa disadari dapat menyebabkan kematian karena merupakan penyakit yang terkadang tidak memiliki gejala atau tanda-tanda dan dapat terjadi pada siapa saja baik pria maupun wanita. Tujuan penelitian ini adalah untuk mengetahui efektifitas pendidikan kesehatan terhadap motivasi diit hipertensi pada lansia hipertensi di Posyandu Lansia Desa Makarti Tulang Bawang Barat tahun 2020. Jenis penelitian yang digunakan dalam penelitian ini adalah kuantitatif. Rancangan penelitian ini menggunakan pendekatan Quasy Experiment dengan desain penelitian two group pretest and posttest design. Populasi dalam penelitian ini adalah seluruh lansia dengan riwayat hipertensi yang mengikuti kegiatan Posyandu Lansia di Desa Makarti Tulang Bawang Barat yang berjumlah 90 orang. Sampel dalam penelitian ini berjumlah 50 orang. Analisis data yang digunakan adalah analisis univariat dan bivariat (Wilcoxon dan Mann Whitney). Hasil penelitian ini menunjukkan bahwa ada perbedaan rata-rata motivasi diit hipertensi sebelum dan sesudah dilakukan pendidikan kesehatan dengan media leaflet pada lansia hipertensi di Posyandu Lansia Desa Makarti Tulang Bawang Barat tahun 2020 dengan p-value = 0,001. Serta ada perbedaan rata-rata motivasi diit hipertensi sebelum dan sesudah dilakukan pendidikan kesehatan dengan media booklet pada lansia hipertensi di Posyandu Lansia Desa Makarti Tulang Bawang Barat tahun 2020 dengan p-value = 0,001. Namun tidak ada perbedaan efektifitas pendidikan kesehatan terhadap motivasi diit hipertensi pada lansia hipertensi menggunakan media leaflet dan booklet di Posyandu Lansia Desa Makarti Tulang Bawang Barat tahun 2020 dengan p value 0,380. Diharapkan setelah dilakukannya penelitian ini, lansia penderita hipertensi tetap tekun melaksanakan diit hipertensi agar tekanan darah tetap stabil.
Mr Impact Dipping Pyramidal-Prismatic Piles and their Resistance to Pressure and Horizontal Load
Authors: Bekbasarov Isabai , Shanshabayev Nurzhan
Published: April 2021

The results of experiments carried out in the field with the use of large-scale models of reinforced concrete driven pyramidal - prismatic piles with different lengths of the pyramidal part are presented. The impact capacity of piles were evaluated of their bearing capacity to the action of indentation and horizontal static loads. It has been established that the driving of pyramidal-prismatic piles is accompanied by both large (by 1.10–1.60 times) and lower (by 8.0–37.0 %) energy consumption for their driving in comparison with conventional pris-matic and pyramidal piles. It was also revealed that under the action of a vertical indentation load, the bearing capacity of the pyramidal-prismatic piles is 1.09–1.48 times, and under the action of a horizontal static load, it is 1.17–1.80 times higher than that of a prismatic pile. It has been established that with an increase in the length of the pyramidal part of the test piles, there is an increase in their bearing capacity by 1.12–1.34 times. Formulas are proposed for determining the bearing capacity of pyramidal-prismatic piles. The research results serve as the basis for the development of recommendations for the calculation and design of pyramidal-prismatic piles.
Design Analysis of High Frequency Linear Transformer with Ārtap Framework
Authors: Orosz Tamás , Stępień Mariusz , Poór Peter
Published: April 2021

This paper presents the design and a design analysis of a coaxial, linear transformer. This is a novel high frequency transformer concept for energy conversion. The examined transformer was designed for 1 MHz nominal frequency. One of the main advantages of the proposed transformer design is its simple winding system. It contains only two coaxial copper tubes, which can be easily manufactured and modeled with high precision. One of the key design tasks is the minimization of the leakage inductance. The inductance of the straight coils depends on the ratio of the height and the diameter of the coil. Therefore, a three-dimensional FEM analysis is sufficient to calculate the optimal length of the linear transformer. The planar 2D model and the 3D model of the transformer are presented in this paper. The accuracy of the 2D and 3D calculation results were compared to each other and to the measurements to show the applicability of the planar 2D models. Moreover, the sensitivity of the losses and the leakage inductance with respect to the winding parameters is presented. The dependencies of the design variables on the performance parameters, such as the power mass density and the leakage inductance of this transformer concept were examined. It was shown that the value of the leakage inductance is a linear function of the ratio of the length and the diameter of the transformer windings.
“Tutti gli occhi del mondo”: Court Networks between Turin and Madrid, 1640–1700
Authors: Raviola Blythe Alice
Published: April 2021

Although the court of Turin’s role in the new balance of power in Europe during the War of the Spanish Succession is well known, far less is known about the strategic function of its collateral courts, such as the court of the princes of Savoy-Carignano. Based on the correspondence of the Savoy ambassador to Madrid, Costanzo Operti (1690–95), this article focuses on these courts to demonstrate the formal and informal diplomatic interplay among male and female aristocrats from 1640 to the end of the seventeenth century. One such noblewoman, Olimpia Mancini of Carignano-Soissons, was an Italian who grew up in the French court and maintained a close relationship with Louis XIV. As the wife of a prince of the Savoy-Carignano branch, she held important positions in Turin, Paris, and Madrid. Mother to the famous prince and military warrior Eugene of Savoy, after she lost her powerful status in France, she sought to find a place in the Madrid court as lady-in-waiting to Queen Marie Louise de Orléans. Her mother-in-law, Marie de Bourbon-Soissons, played an outstanding role in maintaining the honour and prestige of the court of Carignano.
Kent Yurttaşlığı Temelinde Göç ve Kent Konseylerini Düşünmek
Authors: Şahin Savaş Zafer
Published: April 2021

Tüm dünyada; iklim krizi, savaşlar, açlık, etnik çatışmalar ve daha birçok sebeple sayıları giderek artan sayıda insan topluluğunun göçmen haline geldiğine şahit olunmaktadır. Diğer yandan, insan uygarlığı artık kentli bir uygarlık halini almıştır. Bunun sonucunda, dünya nüfusunun yarısından fazlası artık kentlerde yaşamaktadır. Dolayısıyla artan göç, temelde bir kentsel soruna dönüşmüştür. Pek çok ülkede sürmekte olan kentleşme süreçlerinin yeni itici güçlerinden birisi de kentler arası ve uluslararası göçtür. Aslında geçmiş yüzyıllara bakıldığında da durumun özde farklı olmadığı söylenebilir. Ancak, son dönemin farkı, çok daha büyük nüfus kitlelerinin çok daha kısa zamanda, yer ve ülke değiştiriyor olmasıdır. Sonuçta, kitlesel göç hareketleri kısa dönemde sorunlarıyla başa çıkılması gereken bir husus iken, orta ve uzun vadede toplumsal ve kültürel çeşitliliğin bir zenginliğe dönüşmesine olanak tanıyacak bir dinamik üretebilme potansiyeline de sahiptir. Bunun ön koşulu ise öncelikle, göçmen nüfusun yeni yaşam alanlarında hoşgörü ve insan haklarına uygun bir şekilde ele alınabilmesine olanak tanıyacak bir “kent yurttaşlığı” tanımı içerisinde ele alınabilmesidir. Bu makalede önce kuramsal olarak bu anlayışın temelleri ele alınacak, ardından da Türkiye için kent yönetimine katılımın yeni aracı olan kent konseylerinin bu anlamdaki yeri ve potansiyeli değerlendirilecektir.
ABSTRACT IN ENGLISH
Tıtle of Paper
Thıs
Göç ve Kent Özel Sayısı
Authors: Akay Ertürk Selma , Kurtarır Erhan
Published: April 2021

İlk iki paragraf buraya girilecek
Respostas das concentrações de miocinas a partir do estímulo do exercício físico: uma revisão sistemática
Authors: Carvalho Leandro Paim da Cruz , Oliveira Ícaro Cerqueira da Silva , Gomes Matheus Borges da Cruz , Santos Pedro Henrique Silva , Oliveira II Ariel Custódio de , Vitavar Lorena Mariel González , Alves Heitor Barbosa
Published: April 2021

Introdução: O músculo esquelético é o maior órgão endócrino do corpo humano e possui esse papel a partir de peptídeos e proteínas conhecidos como miocinas. As miocinas são citocinas que são produzidas e secretadas pelo músculo em resposta ao estímulo das contrações, podendo agir localmente e/ou cair na circulação e influenciar outros tecidos distantes. O exercício físico é um potente estímulo para adaptações moleculares no organismo e, quando regularmente executado, induz adaptações estruturais e funcionais no músculo esquelético. Sendo assim, o exercício físico possui ação direta nas concentrações dessas miocinas. Objetivo: Baseado nisso, essa pesquisa teve como objetivo investigar, através de uma revisão sistemática de literatura, as respostas das concentrações de miocinas a partir do estímulo do exercício físico. Métodos: As buscas foram realizadas por dois pesquisadores de forma independente, nos bancos de dados do Scielo, Pubmed e BVS, analisando artigos publicados entre 2009 e 2020. Após processo de seleção criterioso em quatro etapas, os trabalhos que chegaram até a terceira etapa foram lidos na integra e submetidos a uma análise de qualidade por via formulário de revisão crítica. Resultados: Ao final do processo, foram selecionados 12 artigos para compor a discussão. Conclusão: Os artigos revisados demonstram que o exercício físico, tanto de forma aguda quanto de forma crônica, é capaz de modular de forma significativa a concentração de diversas miocinas promovendo o aumento da concentração das mesmas, por exemplo da IL-6, IL-15, BDNF e apelina, além de diminuição significativa de miostatina muscular.
Avaliação da força de preensão manual durante uma sessão de hemodiálise
Authors: Dutra Thais Severo , Juliedy Waldow  , Marchesan Moane , Salazar Rodrigo Fernando dos Santos , Keller Kalina Durigon , Moreira Paulo Ricardo , Krug Rodrigo de Rosso
Published: April 2021

Objetivo: Analisar o comportamento da força de preensão manual em pacientes com insuficiência renal crônica durante uma sessão de hemodiálise, estratificado por sexo. Métodos: Aplicou-se o teste de força de preensão manual antes da sessão de hemodiálise, com uma hora de tratamento, com duas horas, três horas e quatro horas, além de uma ficha sociodemográfica e de saúde (aplicada antes da sessão de hemodiálise) em 38 pacientes de uma Clínica Renal localizada no Noroeste do estado do Rio Grande do Sul. As informações obtidas dos ensaios de teste de força de preensão manual foram analisadas por histogramas com representação dos valores médios e desvio-padrão e pelo teste de Mann-Whitney e Wilcoxon em cinco diferentes momentos para cada paciente estudado que estivessem independentes ou ligados, respectivamente. O intervalo de confiança adotado foi de 95% (p≤0,05). Resultados: Evidenciou-se que a força de preensão manual no momento pré-hemodiálise foi significativamente maior nos homens, quando comparados às mulheres e que houve uma redução significativa em todos os momentos do estudo para todos os sujeitos (antes da hemodiálise, após uma hora, duas horas, três horas e quatro horas de tratamento). Esta redução também ocorreu quando os dados foram estratificados por sexo, salienta-se que os homens tiveram valores superiores em todos os momentos. Conclusão: Estes achados mostram que o tratamento hemodialítico interfere negativamente na força de preensão manual de pessoas com insuficiência renal crônica, sendo necessárias estratégias para incremento desta valência física para auxiliar no tratamento e no dia a dia das pessoas em hemodiálise.
Recomendações gerais de cuidado à saúde e de prática de atividade física vs. pandemia da COVID-19
Authors: Vancini Rodrigo Luiz , Lima Leopoldo Ana Paula , Carletti Luciana , Guimarães-Ferreira Lucas , Leopoldo André Soares , Leite Richard Diego , Rinaldi Natália Madalena , Cunha Márcia Regina Holanda da , Bocalini Danilo Sales
Published: April 2021

O Núcleo de Pesquisa e Extensão em Ciências do Movimento Corporal (NUPEM) do CEFD/UFES, representado por professores e pesquisadores elaborou conjuntamente uma carta aberta à comunidade. O grupo vislumbrou a importância de publicar estratégias de gerenciamento e manejo para a manutenção da atividade física e de cuidados de saúde e prevenção durante à pandemia do coronavírus (COVID-19). A pandemia tem alarmado a comunidade esportiva e praticantes de atividade física por seu potencial de transmissão, disseminação, hospitalização e letalidade, principalmente em populações mais vulneráveis, como aquelas com doenças crônicas e idosos. Além de informações gerais sobre a pandemia causada pelo COVID-19, o objetivo deste documento é fornecer informações e recomendações relacionadas à prática de atividade física (AF) para o esclarecimento de profissionais de saúde e pessoas ligadas ao esporte e da AF. Pretendemos assim auxiliar na educação e promoção da saúde por meio de estratégias de prevenção relacionadas à pandemia e à prática de atividade física. Nesta perspectiva, de acordo com as diretrizes atuais, recomenda-se evitar ao máximo o tempo de inatividade física e comportamentos sedentários. Ainda, é recomendada a prática de 150-300 min/semana de AF aeróbia de intensidade moderada e 2 sessões de atividades que envolvam treinamento de força muscular, contribuindo com a manutenção do estado de saúde. No entanto, um volume menor de AF produz também benefícios à saúde, ou seja, realizar alguma AF é melhor que nenhuma e movimentar mais e repousar menos também.
The Role of Applied Linguistics in English Teaching Materials in Higher Education
Authors: Syakur Abd.
Published: April 2021

The goal of this research was to find out what role linguistics plays in the English teaching process that takes place at Bakti Indonesia University. The lecturer of Bakti Indonesia University, teaching English along with technological developments can be implemented with various methods and development efforts. One of the efforts made was to optimize the linguistics role, especially applied linguistics, in English teaching process. It is very natural in English teaching process as broad knowledge which is fundamental about the principles of language being learned. The linguistic theories of English lecturers and teaching staff will not find any problems in describing a language especially English in its use. The research method used was descriptive with qualitative approach in its implementation. From the results can be concluded that the teaching method of English language material is not only learning system that plays major role, but more than that it is communication medium that can understand the basic principles of English teaching. For a student that learning any language requires a lot of process and practice in English.
Aportación sobre la situación actual del arte urbano por jóvenes artistas emergentes
Authors: Atienza Belén Díez
Published: April 2021

La necesidad de repensar diferentes actuaciones entorno el arte urbano ha generado un cuestionamiento a nivel conceptual y del proceso creativo de los artistas del arte urbano. Como creadores en estado emergente se ofrecen una serie de opiniones y cuestionamientos sobre el lugar donde se ejecutan estas intervenciones, el factor artístico como se ve diferido cuando una actuación encargada o como la entrada a los museos descontextualiza la intención para la que fue creada. Además se ambiciona a incorporar en la formación universitaria artística procesos reflexivos y participativos para estudiantes en crecimiento de configurarse como dichos artistas de este futuro inmediato. Por último se reflexiona sobre la importancia de adjuntar en el registro el proceso creativo y el discurso artístico sobre el que se asienta la obra además de las pretensiones sobre la perdurabilidad de la obra.
Implementasi Waterfall Model Dalam Pengembangan Sistem Informasi Eksekutif Penduduk
Authors: Prasetyo Ekkal , Putra Ade
Published: April 2021

Kebutuhan informasi menjadi sangat penting terutam dalam proses pengambilan keputusan. Salah satu cara yang dapat digunakanyaitu menggunakan teknologi informasi dan komunikasi seperti sistem informasi. sistem informasi sendiri memiliki berbagai macam diantaranya yaitu sistem informasi eksekutif yang banyak digunakan untuk menyajikan informasi kepada pihak eksekutif dalam mengambil keputusan atau kebijakan. Seperti halnya yang terjadi diberbagai kecamatan saat ini kebutuhan informasi penduduk menjadi sangat penting mengingat dibutuhkan dalam pengambilan kebijakan bagi pemerintah. untuk itu di dalam penelitian ini dibuat sebuah sistem informasi eksekutif penduduk guna membantu memetakan keadaan penduduk berdasarkan data kependudukan itu sendiri. untuk menghasilkan sistem informasi eksekutif sesuai dengan kebutuhan eksekutif maka proess pengembangan digunakan waterfall model dengan lima tahapan pengembangan communication, planning, modeling, construction, dan deployment. Hasil dari pengembangan berupa sistem informasi eksekutif yang dapat memberikan informasi secara visual kepada pihak terkait. Sistem informasi juga berjalan dengan baik yang dibutkikan dari hasil pengujian yang dilakukan.
Asset Management Information System Perfomance Analysis (SIMASET) Using IT Balanced Scorecard Case Study : Salatiga City Region Revenue Management Unit
Authors: Priyanti Fricila Beti , Wijaya Agustinus Fritz
Published: April 2021

Technological developments greatly influence the increasing disruption to the system and system used by the user. Therefore, it is necessary to see how optimal the system is being used by an organization. The Regional Revenue Management Unit (UPPD) of Salatiga City is also inseparable from the development of information technology. By using several information systems, they try to keep up one of the technological developments by using the Asset Management Information System (SIMASET) based website for data collection of goods in and out of the UPPD Salatiga City. In this study using the IT Balanced Scorecard method as a planning solution in terms of performance measurement and monitoring the realization of the value or business benefits and benefits of Information Technology which the IT Balanced Scorecard has four perspectives namely Company Contribution Perspective, User Orientation Perspective, Improvement Perspective Operations and Future Orientation Perspectives. Results and discussion of the 4 Perspectives on Balanced IT Scorecard in this study, it is expected that the User Orientation Perspective and the Future Perspective is doing some improvement because in the User Orientation Perspective the system used often has errors and is quite convoluted in use, the Future Orientation Perspective is almost the same as the User Orientation Perspective, where the quality of the new system still needs to be improved again.
Analisis dan Perancangan Sistem Informasi Panduan Kesehatan Balita
Authors: Lestari Merrryana , Sediyono Eko
Published: April 2021

Immunization, nutritional support for food vitamins and nutritional content from food are important components to support good children's growth and development. However, the number of malnutrition and malnutrition in Indonesia is still high, causing many children under five to experience stunting during the golden age. Through this research, analysis and design of mobile-based information systems that can be accessed anywhere and anytime as needed is carried out. The design of this information system can be used as a guide for young mothers regarding child health information needed, especially during the growth and development period of toddlers by monitoring growth curves and providing health recommendations through the calculation of the Body Mass Index (BMI) in toddlers and can also be used as a reminder and recording of immunization data in children under five.
Fonksiyonel Nörolojik Semptom Bozukluğunda Bilişsel Davranışçı Tedavinin Bilişsel Hatalar Üzerine Etkisi
Authors: ÖRÜM Mehmet Hamdi
Published: April 2021

Amaç: Amacımız fonksiyonel nörolojik semptom bozukluğu (FNSD) tanılı hastalarda farmakoterapi (FT) ve FT ile bilişsel davranışçı tedavi (BDT) kombinasyonunun bilişsel hatalar üzerine etkisini karşılaştırmaktır.

Gereç ve Yöntem: Bu ileriye yönelik çalışmada FNSD tanısı DSM-5’e göre konuldu. Alt tipler klinik ve somatoform dissosiyasyon ölçeği (SDÖ)’nin birlikte değerlendirilmesiyle belirlendi. Bilişsel hatalar düşünce özellikleri ölçeği (DÖÖ) ile, hastanın genel durumu global değerlendirme ölçeği (GAS) ile değerlendirildi.

Bulgular: FT grubu 37 hastadan, FT+BDT grubu 20 hastadan oluşuyordu. Gruplar arasında ortalama yaş (p=0,312), ortalama eğitim süresi (p=0,345) açısından anlamlı farklılık saptanmadı. Tedavi öncesinde, DÖÖ-IP (p=0,085), DÖÖ-PA (p=0,145), SDÖ (p=0,132) ve GAS (p=0,421) açısından gruplar arasında anlamlı farklılık saptanmadı. Hem FT (p=0,011), hem de FT+BDT (p
Screen Wall Fire Resistance Investigation
Authors: Eremina Tatiana , Korolchenko Dmitry , Fadeev V. E.
Published: April 2021

The assessment of fire resistance for building constructions has been carried out by the solution of the heat engineering problem for heating up building structures under the conditions of non-stationary heat exposure with standard fire conditions. The finite element method is used as the solution method. Numerical simulation of heating of considered building structures under fire conditions was carried out using the Ansys Mechanical computer complex, which allows for a thermal engineering design to be calculated on the basis of its software model. The resulting functional dependence allows for determining the actual fire resistance of Pf depending on the thickness of sheets δ of the outer skin made of the basalt fire-proof material, as well as the geometric parameters of the protective screen (δ) depending on the required fire resistance from the condition of compliance with the requirements of constructive fire safety (Pf > Preq). Experimental studies to determine the fire resistance for membrane wall structures showed that an increase in temperature on its unheated surface vs. structure temperature prior to testing more than 180° С (195°С) occurs not earlier than 31 min. Upon reaching the critical temperatures on the unheated surface of the membrane wall structure independing on its thickness, the fire resistance limits REI 30-REI 120 are reached.
Nanomaterials for Tumor Hypoxia Relief to Improve the Efficacy of ROS-Generated Cancer Therapy
Authors: Ruan Changping , Su Kaihua , Zhao Dongmin , Lu Ai , Zhong Chaoran
Published: April 2021

Given the fact that excessive levels of reactive oxygen species (ROS) induce damage to proteins, lipids, and DNA, various ROS-generating agents and strategies have been explored to induce cell death and tumor destruction by generating ROS above toxic threshold. Unfortunately, hypoxia in tumor microenvironment (TME) not only promotes tumor metastasis but also enhances tumor resistance to the ROS-generated cancer therapies, thus leading to ineffective therapeutic outcomes. A variety of nanotechnology-based approaches that generate or release O2 continuously to overcome hypoxia in TME have showed promising results to improve the efficacy of ROS-generated cancer therapy. In this minireview, we present an overview of current nanomaterial-based strategies for advanced cancer therapy by modulating the hypoxia in the TME and promoting ROS generation. Particular emphasis is put on the O2 supply capability and mechanism of these nanoplatforms. Future challenges and opportunities of design consideration are also discussed. We believe that this review may provide some useful inspiration for the design and construction of other advanced nanomaterials with O2 supply ability for overcoming the tumor hypoxia-associated resistance of ROS-mediated cancer therapy and thus promoting ROS-generated cancer therapeutics.
Nanoparticles as Potential Novel Therapies for Urinary Tract Infections
Authors: Sánchez Sofía V. , Navarro Nicolás , Catalán-Figueroa Johanna , Morales Javier O.
Published: April 2021

Urinary tract infection (UTI) is one of the most common reasons for antibiotic treatment. Nevertheless, uropathogens are steadily becoming resistant to currently available therapies. In this context, nanotechnology emerges as an innovative and promising approach among diverse strategies currently under development. In this review we deeply discuss different nanoparticles (NPs) used in UTI treatment, including organic NPs, nanodiamonds, chemical and green synthesized inorganic NPs, and NPs made of composite materials. In addition, we compare the effects of different NPs against uropathogens in vivo and in vitro and discuss their potential impact the in the near future.
Multimodal Capture of Patient Behaviour for Improved Detection of Early Dementia: Clinical Feasibility and Preliminary Results
Authors: Jonell Patrik , Moëll Birger , Håkansson Krister , Henter Gustav Eje , Kucherenko Taras , Mikheeva Olga , Hagman Göran , Holleman Jasper , Kivipelto Miia , Kjellström Hedvig , Gustafson Joakim , Beskow Jonas
Published: April 2021

Non-invasive automatic screening for Alzheimer’s disease has the potential to improve diagnostic accuracy while lowering healthcare costs. Previous research has shown that patterns in speech, language, gaze, and drawing can help detect early signs of cognitive decline. In this paper, we describe a highly multimodal system for unobtrusively capturing data during real clinical interviews conducted as part of cognitive assessments for Alzheimer’s disease. The system uses nine different sensor devices (smartphones, a tablet, an eye tracker, a microphone array, and a wristband) to record interaction data during a specialist’s first clinical interview with a patient, and is currently in use at Karolinska University Hospital in Stockholm, Sweden. Furthermore, complementary information in the form of brain imaging, psychological tests, speech therapist assessment, and clinical meta-data is also available for each patient. We detail our data-collection and analysis procedure and present preliminary findings that relate measures extracted from the multimodal recordings to clinical assessments and established biomarkers, based on data from 25 patients gathered thus far. Our findings demonstrate feasibility for our proposed methodology and indicate that the collected data can be used to improve clinical assessments of early dementia.
Case Report: Combined Intravenous Infusion and Local Injection of CAR-T Cells Induced Remission in a Relapsed Diffuse Large B-Cell Lymphoma Patient
Authors: Hu Linhui , Wu Fan , Wang Huiping , Zhu Weiwei , Wang Juan , Yu Fengxiang , Zhai Zhimin
Published: April 2021

Relapsed diffuse large B-cell lymphoma (DLBCL) is a disease with a poor prognosis. Recent clinical trials results showed chimeric antigen receptor (CAR) T cell therapy has a promising role in treating relapsed DLBCL. Unfortunately, patients with extranodal lesions respond poorly to CAR-T cells administered intravenously. Herein, we evaluated the efficacy and safety of a new treatment strategy of CAR-T cells, combining intravenous infusion with local injection of CAR-T cells, in a relapsed DLBCL patient with extranodal lesions. The patient achieved durable remission and without severe adverse effects after CAR-T cells treatment. During the follow-up period of one year, the patient remained in good condition. In conclusion, combining intravenous injection with a local injection for CAR-T cell is a feasible strategy for relapsed DLBCL patients with extranodal lesions.
Predictive Markers of Bronchial Hyperreactivity in a Large Cohort of Young Adults With Cough Variant Asthma
Authors: Malerba Mario , Ragnoli Beatrice , Azzolina Danila , Montuschi Paolo , Radaeli Alessandro
Published: April 2021

Cough variant asthma (CVA), a common asthma phenotype characterized by nonproductive cough and bronchial hyperreactivity (BHR), is usually detected by bronchial provocation tests (BPTs) which are time-consuming, expensive, and unsafe. The primary study objective was to provide proof of concept for the use of fractional exhaled nitric oxide (FENO), eosinophil count percentage in induced sputum (sEOS%), forced expiratory flow between 25 and 75% of forced vital capacity (FEF25–75%) % predicted value, and FEF25–75% z-scores as surrogate markers predicting BHR in young adults with suspected CVA; the secondary objective was to compare the diagnostic performance of the various techniques. Three hundred and ten subjects (median age 24 years) were included in a cross-sectional study. Subjects were characterized as BHR positive (POS) (n = 147) or BHR negative (NEG) (n = 163) according to methacholine BPT. Classification accuracies were expressed as areas under the receiver operator characteristic curves (AUC). Compared with BHR NEG, FEF25–75% % predicted value and FEF25–75% z-scores were lower in the BHR POS group (p < 0.001), whereas FENO (p < 0.001) and sEOS% were higher (p < 0.001). AUC values for detecting BHR were as follows: FENO, 0.98 (SD = 0.02); sEOS%, 0.98 (SD = 0.02); FEF25–75% % pred, 0.93 (SD = 0.05); FEF25–75% z scores, 0.92 (SD = 0.05). Optimal cutoff values (OCV) for BHR prediction were as follows: FENO, 32.7 ppb (sensitivity = 0.93, specificity = 0.96), sEOS%, 3.80% (sensitivity = 0.94, specificity = 0.94), FEF25–75% % predicted value, 80.0% (sensitivity = 0.90, specificity = 0.87), and FEF25–75% z-score, −0.87 (sensitivity = 0.89, specificity = 0.87). Non-invasive/semi-invasive airway inflammatory or small airway functional measures might be used as surrogate markers predicting BHR in young adults with suspected CVA.
Tanshinone IIA Protects Against Cerebral Ischemia Reperfusion Injury by Regulating Microglial Activation and Polarization via NF-κB Pathway
Authors: Song Zhibing , Feng Jingjing , Zhang Qian , Deng Shanshan , Yu Dahai , Zhang Yuefan , Li Tiejun
Published: April 2021

Tanshinone IIA, a fat-soluble diterpenoid isolated from Salvia miltiorrhiza Bunge, has been shown to attenuate the cerebral ischemic injury. The aim of this study was to examine the effects on neuroprotection and microglia activation of Tanshinone IIA. Male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO). We found that Tanshinone IIA significantly reduced infarction volume, alleviated neuronal injuries, reduced the release of TNF-α, IL-1β, and IL-6, increased SOD activity, and decrease the content of MDA in MCAO rats. Hematoxylin and eosin staining, Nissl staining, TUNEL staining and immunofluorescence staining showed that Tanshinone IIA improved the distribution and morphology of neurons in brain tissues and reduced apoptosis. In addition, Co-immunofluorescence staining of rat brain tissues and the mRNA expression levels of CD11b, CD32, iNOS, and Arg-1, CD206, IL-10 in BV2 cells indicated that Tanshinone IIA can downregulate M1 microglia and upregulate M2 microglia in MCAO rats. Further, BV2 microglial cells were subjected to oxygen-glucose deprivation, the protein expression levels were detected by western blot. Tanshinone IIA inhibited the expression levels of NF-κB signaling pathway related proteins. Taken together, this study suggested that Tanshinone IIA modulated microglial M1/M2 polarization via the NF-κB signaling pathway to confer anti-neuroinflammatory effects.
Human Pluripotent Stem Cells for Modeling of Anticancer Therapy-Induced Cardiotoxicity and Cardioprotective Drug Discovery
Authors: Keung Wendy , Cheung Yiu-Fai
Published: April 2021

Anticancer chemotherapies have been shown to produce severe side effects, with cardiotoxicity from anthracycline being the most notable. Identifying risk factors for anticancer therapy-induced cardiotoxicity in cancer patients as well as understanding its underlying mechanism is essential to improving clinical outcomes of chemotherapy treatment regimens. Moreover, cardioprotective agents against anticancer therapy-induced cardiotoxicity are scarce. Human induced pluripotent stem cell technology offers an attractive platform for validation of potential single nucleotide polymorphism with increased risk for cardiotoxicity. Successful validation of risk factors and mechanism of cardiotoxicity would aid the development of such platform for novel drug discovery and facilitate the practice of personalized medicine.
On the Dual Nature of Adoption Processes in Complex Networks
Authors: Iacopini Iacopo , Latora Vito
Published: April 2021

Adoption processes in socio-technological systems have been widely studied both empirically and theoretically. The way in which social norms, behaviors, and even items such as books, music, or other commercial or technological products spread in a population is usually modeled as a process of social contagion, in which the agents of a social system can infect their neighbors on the underlying network of social contacts. More recently, various models have also been proposed to reproduce the typical dynamics of a process of discovery, in which an agent explores a space of relations between ideas or items in search for novelties. In both types of processes, the structure of the underlying networks, respectively, the network of social contacts in the first case, and the network of relations among items in the second one, plays a fundamental role. However, the two processes have been traditionally seen and studied independently. Here, we provide a brief overview of the existing models of social spreading and exploration and of the latest advancements in both directions. We propose to look at them as two complementary aspects of the same adoption process: on the one hand, there are items spreading over a social network of individuals influencing each other, and on the other hand, individuals explore a network of similarities among items to adopt. The two-fold nature of the approach proposed opens up new stimulating challenges for the scientific community of network and data scientists. We conclude by outlining some possible directions that we believe may be relevant to be explored in the coming years.
Differential Expression of CADM1 in Gastrointestinal Stromal Tumors of Different Sites and with Different Gene Abnormalities
Authors: Yuan Jiayin , Kihara Takako , Kimura Neinei , Hashikura Yuka , Ohkouchi Mizuka , Isozaki Koji , Takahashi Tsuyoshi , Nishida Toshirou , Ito Akihiko , Hirota Seiichi
Published: April 2021

Gastrointestinal stromal tumor (GIST), the most common mesenchymal tumor of the human gastrointestinal tract, differentiating toward the interstitial cell of Cajal (ICC), arises predominantly in the stomach and small intestine. Small intestinal GISTs appear to have worse prognosis than gastric GISTs. In a pilot study of a cDNA expression chip using several GISTs, we found that Cell Adhesion Molecule 1 (CADM1), which could contribute to tumor growth and infiltration, is expressed more strongly in small intestinal GISTs than gastric GISTs. In the present study, we examined CADM1 expression in GISTs of different sites and with different gene abnormalities using a large number of gastric and small intestinal GISTs. First, immunoblotting confirmed significantly higher CADM1 expression in small intestinal GISTs with exon 11 c-kit mutation than gastric GISTs with exon 11 c-kit mutation. Real-time PCR also revealed that small intestinal GISTs with exon 11 c-kit mutation showed significantly higher CADM1 mRNA than gastric GISTs with exon 11 c-kit mutation. Although most small intestinal GISTs showed high CADM1 mRNA expression regardless of gene abnormality types, different CADM1 expression was detected between gastric GISTs with c-kit mutation and those with PDGFRA mutation. Immunohistochemistry showed that many small intestinal GISTs were CADM1-positive but most gastric GISTs CADM1-negative or -indefinite. In the normal gastric and small intestinal walls, immunoreactivity of CADM1 was detected only in nerves, but neither in gastric ICCs nor small intestinal ICCs, indicating that the high CADM1expression in small intestinal GISTs might be acquired during tumorigenesis. Different CADM1 expression between gastric and small intestinal GISTs might be related to different prognoses between them. Further functional experiments are needed to elucidate the role of CADM1 on GIST biology, and there is a possibility that targeting therapy against CADM1 has a preventive effect for tumor spreading in small intestinal GISTs.
Tuftelin 1 (TUFT1) Promotes the Proliferation and Migration of Renal Cell Carcinoma via PI3K/AKT Signaling Pathway
Authors: Lin Hua , Zeng Weifeng , Lei Yuhang , Chen Desheng , Nie Zhen
Published: April 2021

Tuftelin 1 (TUFT1), a protein functioning distinctively in different tissues, is reported to be elevated in several types of cancers and the elevation of TUFT1 is correlated with unfavorable clinicopathologic characteristics and poor survival. However, the involvement of TUFT1 in renal cell carcinoma (RCC) remains unknown. In the current study, we investigated the role of TUFT1 in RCC and potential underlying mechanisms. RT-PCR and Western blot analysis showed that both the mRNA and protein levels of TUFT1 were increased in primary RCC tissue and RCC cell lines. TUFT1 overexpression in RCC cells resulted in enhanced cell proliferation and migration while knockdown of TUFT1 by contrast decreased the growth and migration of the RCC cells, indicating TUFT1 expression is involved in RCC cell growth and migration. The involvement of TUFT1 in the epithelial-mesenchymal transition (EMT) of RCC cells was also determined by measuring the expression of EMT-related markers. Our data showed that TUFT1 overexpression promoted RCC cell EMT progression while knockdown of TUFT1 suppressed such process. Further signaling pathway inhibition assay revealed that TUFT1-induced RCC cell growth, migration and EMT was significantly suppressed by PI3K inhibitor, but not JNK or MEK inhibitors. In addition, TUFT1 overexpression enhanced the AKT phosphorylation, a key member of the PI3K signaling pathway, while PI3K inhibitor suppressed such process. Taken together, our study showed that TUFT1 expression was elevated in RCC and such elevation promoted the proliferation, migration and EMT of RCC cells in vitro, through PI3K/AKT signaling pathway. The findings of our current study imply that TUFT1 is involved in RCC tumorigenesis, and it may serve as a biomarker for RCC diagnosis and a potential target for RCC treatment.
Pharmacist-Driven Antibiotic Stewardship Program in Febrile Neutropenic Patients: A Single Site Prospective Study in Thailand
Authors: Jantarathaneewat Kittiya , Apisarnthanarak Anucha , Limvorapitak Wasithep , Weber David J. , Montakantikul Preecha
Published: April 2021

The antibiotic stewardship program (ASP) is a necessary part of febrile neutropenia (FN) treatment. Pharmacist-driven ASP is one of the meaningful approaches to improve the appropriateness of antibiotic usage. Our study aimed to determine role of the pharmacist in ASPs for FN patients. We prospectively studied at Thammasat University Hospital between August 2019 and April 2020. Our primary outcome was to compare the appropriate use of target antibiotics between the pharmacist-driven ASP group and the control group. The results showed 90 FN events in 66 patients. The choice of an appropriate antibiotic was significantly higher in the pharmacist-driven ASP group than the control group (88.9% vs. 51.1%, p < 0.001). Furthermore, there was greater appropriateness of the dosage regimen chosen as empirical therapy in the pharmacist-driven ASP group than in the control group (97.8% vs. 88.7%, p = 0.049) and proper duration of target antibiotics in documentation therapy (91.1% vs. 75.6%, p = 0.039). The multivariate analysis showed a pharmacist-driven ASP and infectious diseases consultation had a favorable impact on 30-day infectious diseases-related mortality in chemotherapy-induced FN patients (OR 0.058, 95%CI:0.005–0.655, p = 0.021). Our study demonstrated that pharmacist-driven ASPs could be a great opportunity to improve antibiotic appropriateness in FN patients.
Comparative Studies on Different Extraction Methods of Centella asiatica and Extracts Bioactive Compounds Effects on Antimicrobial Activities
Authors: Idris Farhana Nazira , Mohd Nadzir Masrina
Published: April 2021

The interest of consumers in using products containing phytochemicals derived from plants is growing day by day due to the shift of consumers’ preferences from convenience to environmental sustainability. One plant utilized in many products is Centella asiatica, a herb commonly used in folk medicine, health supplements, and beauty products. Extraction of bioactive compounds from C. asiatica was performed using conventional methods and modern methods (e.g., microwave or ultrasound-assisted and subcritical water extraction). This review summarizes the variety of methods used to extract active compounds from C. asiatica, their influence on the bioactive compounds and antimicrobial activity in vitro and in vivo, and the safety and toxicology of C. asiatica extract.