bluuebunny/crossref_metadata_2025 huggingface dataset:
Digital Parenting: Utilizing Technology to Instill Islamic Education Values in Young Children
Authors: Astuti Ria , Erni Munastiwi  , Muqowim  , Muammar Qadafi
Published: March 2023

Early use of technology always has advantages and disadvantages in social interactions. Some neighborhood organizations believe that technology may promote accountability, pragmatism, security, and convenience. Other groups, meanwhile, believe that gadgets are prone to criminality. Gadgets must be present since they are an unavoidable aspect of life. Use intended for young children requires parental supervision. Similarly, technology can be employed as a teaching tool. The study's goal was to investigate how Islamic education ideals are taught to young children through the use of technology. This study used descriptive qualitative research as its methodology. ways for gathering data through observation, interviews, and documentation. Ten parents of young children participated as informants in the study. Data reduction and exposure stages, as well as inference and data verification, are all used in technical analysis of the data. By using three different procedures and data sources, the veracity of the data is tested. The study's findings demonstrate that: First, early childhood care can be provided using either an authoritative parenting style, which limits children's independence while granting them authority, or a permissive parenting style, which pampers them. Second, using technology as media is one way that parents today are instilling Islamic education values which includes aspects of aqidah, worship (ibadah), and morals (akhlak) in their children. Third, gadgets have a negative impact on early childhood including cyberbullying, pornography, blasphemy and speaking impolitely in cyberspace, then children think instantly, are less active, addicted to gadgets and result in a consumptive lifestyle.
Pengaruh Serbuk Daun Jeruk Purut (Citrus hystrix DC.) dan Daun Sirsak (Annona muricata L) sebagai Senyawa Volatil Terhadap Mortalitas Hama Gudang (Sitophilus oryzae L.) pada Beras
Authors: Yuliani Linda , Jadmiko Moch Wildan
Published: March 2023

Beras merupakan komoditas penting bagi negara Indonesia yang digunakan sebagai bahan makanan pokok. Beras yang disimpan dalam waktu lama menyebabkan penurunan kualitas dan kuantitas. Salah satu faktor yang menyebabkannya adalah serangga hama gudang. Hama gudang utama beras adalah Sitophilus oryzae. Kerusakan beras akibat S. oryzae dapat mencapai sekitar 10-65% dalam kondisi penyimpanan sedang, dan dalam kondisi penyimpanan yang lama mencapai 80%. Salah satu bahan alami insektisida nabati yaitu daun jeruk purut (C. hystrix) dan daun sirsak (A. muricata). Penelitian ini bertujuan untuk mengetahui pengaruh serbuk daun jeruk purut dan daun sirsak sebagai senyawa volatil terhadap mortalitas, pertambahan jumlah imago S. oryzae, kerusakan dan susut bobot beras. Metode penelitian menggunakan Rancangan Acak Lengkap (RAL) dengan 6 perlakuan sebanyak 4 ulangan. Perlakuan tersebut terdiri dari kontrol, 10 gram serbuk daun jeruk purut, 10 gram serbuk daun sirsak, 5 gram serbuk daun jeruk purut+5 gram serbuk daun sirsak, 7,5 gram serbuk daun jeruk purut+2,5 gram serbuk daun sirsak, dan 7,5 gram serbuk daun sirsak+2,5 gram serbuk daun jeruk purut. Data hasil pengamatan dianalisis dengan menggunakan analisis keragaman (ANOVA) α 0,05 dan apabila berbeda nyata, maka dilakukan uji lanjut DMRT (Duncan Multiple Range Test) α 0,05. Hasil penelitian menunjukkan bahwa perlakuan terbaik terdapat pada perlakuan 10 gram serbuk daun jeruk purut/100 gram beras (A1) dengan mortalitas sebesar 67,5% dan pertambahan jumlah imago sebanyak 14 ekor. Perlakuan yang paling baik dalam mengurangi resiko susut bobot beras terdapat pada perlakuan 10 gram serbuk daun jeruk purut/100 gram beras (A1) dengan persentase susut bobot sebesar 2,47%.
Analisis Spektroskopi Air Kelapa dan Biji Chia sebagai Minuman Kesehatan
Authors: Alwi Muhammad , Helilusiatingsih Nunuk , Qumillaila Qumillaila , Annisa Ayu
Published: March 2023

Minuman yang bagus kesehatan adalah air putih atau air yang mengandung senyawa bioaktif dan zat gizi seperti mineral dan lainnya. Air kelapa yang masih muda  sangat disukai oleh masyarakat karena rasanya segar dan memiliki zat aktif yang berguna untuk menangkal racun dan menambah nilai gizi yang alami baik untuk tubuh kita dan bagi olahragawan. Perlu dilakukan penelitian inovasi minuman kesehatan dari campuran air kelapa dan biji chia untuk memeroleh khasiat yang baik bagi tubuh saat dan setelah beraktivitas olahraga dan lainnya.  Tujuan penelitian ini adalah untuk mengetahui potensi campuran air kelapa dan biji chia sebagai minuman olahraga. Metode penelitian yang dilakukan adalah preparasi minuman dari air kelapa dan biji chia, kemudian dilakukan analisa spektroskopi AAS untuk mengetahui kadar mineral Na, K, Ca, dan Mg. Selanjutnya dilakukan analisa spektroskopi FTIR untuk mengetahui kandungan senyawa antioksidan. Untuk mengetahui aktivitas atioksidan dilakukan dengan metode DPPH dan spektroskopi Uv-Vis. Hasil penelitian menunjukkan bahwa kandungan Na pada tiap sampel berturut-turut AKC 1 : 635,66 mg/kg, AKC 2 638,79 mg/kg, AKC 3 :  639,21 mg/kg, AKC 4 : 639, 98 mg/kg. Kandungan K pada tiap sampel berturut-turut K berturut-turut AKC 1 : 242,93 mg/kg, AKC 2 : 244,57 mg/kg, AKC 3 : 245,72 mg/kg, AKC 4 : 246,02 mg/kg. kandungan Ca pada tiap sampel berturut-turut AKC 1 : 550,18 mg/kg, AKC 2 : 556,49 mg/kg, AKC 3 : 555,26 mg/kg, AKC 4 : 556,78 mg/kg. kandungan Mg berturut-turut AKC 1 : 30,55 mg/kg, AKC 2 : 31,67 mg.kg, AKC 3 : 31,92 mg/kg, AKC 4 : 32,01 mg/kg. Hasil spektroskopi FTIR menunjukkan tiap sampel mengandung senyawa antioksidan kampferol, myrisetin, quercetin, asam sinamat, dan asam kafeat. Hasil uji aktivitas antioksidan menunjukkan bahwa aktivitas antioksidan masing-masing sampel termasuk kuat dengan IC50 berturut-turut AKC 1 : 62,98 ppm, AKC 2 : 63,19 ppm, AKC 3 : 65,02 ppm, AKC 4 : 65,85 ppm. Kesimpulan dari penelitian ini adalah dari hasil spektroskopi menunjukkan campuran air kelapa dan biji chia memiliki kandungan yang bermanfaat bagi tubuh. Campuran air kelapa dan biji chia berpotensi sebagai minuman kesehatan dengan formula terbaik adalah AKC 4 dengan formula air kelapa dan biji chia 200 ml : 10 gram.
Meningkatkan Pemahaman Konsep Perkalian dan Pembagian Kelas 3 Melalui Permainan Loncat Katak
Authors: Jayadi Arfan Rahman
Published: March 2023

Penelitian ini dilatarbelakangi karena belum optimalnya pemahaman siswa pada materi perkalian, dan pembagian, serta siswa masih merasa kesulitan pada saat menjawab dan menyelesaikan soal permasalahan tersebut. Tujuan dari penelitian ini adalah untuk mengetahui sejauh mana pemahaman siswa dalam memahami materi perkalian dan pembagian dengan menggunakan permainan lompat katak. Metode yang digunakan pada penelitian ini adalah dengan menggunakan metode tindakan kelas supaya bisa menerapkan, dan mengkaji hasil yang didapatkan secara langsung, disamping itu menggunakan metode survei untuk mengetahui perasaan yang dialami oleh siswa, dan juga menggunakan metode eksperimen supaya bisa mengetahui hasil permainan lompat katak pada pemahaman siswa. Subjek penelitian adalah siswa kelas III SD Negeri 4 Sindangsari dengan jumlah 18 orang. Instrumen pada penelitian ini dengan menggunakan lembar pretest, posttest, dan survei. Hasil dari penelitian ini adalah untuk menunjukkan bahwa permainan lompat katak dapat membantu siswa dalam memahami konsep materi perkalian, dan pembagian, serta bisa mengaplikasikannya di dalam kehidupan sehari-hari.
Pengembangan Pendekatan Sains Teknologi Masyarakat menjadi Model Pembelajaran
Authors: Insani Mutiara Citra , Januar Ramdan , Halimah Wiwin
Published: March 2023

Sains dan Teknologi merupakan suatu masalah yang urugen dalam masyarakat terutama untuk kehidupan manusia. Perihal apapun tidak lepas dari campur tangan sains dan teknologi. Karena peranannya yang sangat besar itulah sehingga kita perlu mengetahui apa yang di maksud dengan sains dan teknologi serta apakah terdapat keterkaitan antara sains dan teknologi dengan nilai-nilai yang terkandung dalam masyarakat baik nilai sosial, moral dan budaya.
‘How Did This Happen?’: Making Retrospective, Present and Prospective Sense of Intimate Relationships Where Men Have Been Violent
Authors: Ólafsdóttir Katrín , Hearn Jeff
Published: March 2023

In seeking to explain intimate partner violence (IPV), feminist research has shifted its focus from individual explanations to the social contexts of such violence. Adopting such a perspective, we explore the narratives of three men who identify as perpetrators of violence and three women who identify as victims/survivors of IPV. Our analyses focus on how the participants present their relationships, employing the notion of affective – discursive practices as informing, at times constituting, the participants’ experiences. Their stories are characterised by a chronological line – retrospective, present and prospective. Their understandings change in framing their experiences, with the relationships themselves becoming affective–discursive practices, albeit figuring differently in the participants’ stories across time. Our findings also underline the significance of shame as a regulatory mechanism sustaining heteronormative practices.
Dreams of Flight: The Lives of Chinese Women Students in the West
Authors: Gaetano Arianne M.
Published: March 2023

Review of the book Dreams of Flight: The Lives of Chinese Women Students in the West, by Fran Martin.
Prolonged, Atypical and Fulminant Mpox in an HIV/HBV Coinfected Patient: A Case Report
Authors: Perez Hernandez Felipe De Jesus , Alvarez Sanchez Victor Aaron , Torres Erazo Darwin Stalin , Ambriz Huerta Rober , Ceballos Perez Monica , Franco Gonzalez Carlos David
Published: March 2023

Mpox (monkeypox) is a zoonotic disease that has been endemic in African countries for decades, with a recent outbreak in several countries around the world. A 39-year-old male with HIV-HBV coinfection and poor adherence to antiretroviral treatment, who was severely immunocompromised and had a concurrent diagnosis of Mpox infection, presented to our hospital with disseminated dermatosis (over 350 lesions), perianal ulcers, odynophagia, oral intolerance, diarrhea, and soft-tissue bacterial superinfection of the lower extremities. Laboratory results were consistent with HBV infection, with an absolute CD4 cell count of 40 cells/uL and a positive PCR result for Mpox. An abdominopelvic CT scan showed evidence of severe proctitis and perineal soft-tissue infection. After 65 days of Mpox PCR, new lesions in the vesicular stage continued to appear, eventually developing hemodynamic instability and sepsis, resulting in a fatal outcome. Our case highlights the importance of intentionally looking for risk factors such as HIV/HBV coinfection and evaluating immune status (CD4 cell count) in patients with severe Mpox infection because it could be related to higher mortality.
Discrete Analogue of Fishburn’s Fractional-Order Stochastic Dominance
Authors: Yin Hoover H. F. , Wang Xishi , Mak Hugo Wai Leung , Au Yong Chun Sang , Chan Ian Y. Y.
Published: March 2023

A stochastic dominance (SD) relation can be defined by two different perspectives: One from the view of distributions, and the other one from the view of expected utilities. In early days, Fishburn investigated SD from the view of distributions and we refer this perspective as Fishburn’s SD. One of his many results was the development of fractional-order SD for continuous distributions. However, discrete fractional-order SD may not be generalized directly since some properties of fractional calculus do not have a discrete counterpart. In this paper, we develop a discrete analogue of fractional-order SD from the view of distributions. We generalize the order of SD by Lizama’s fractional delta operator, show the preservation of SD hierarchy, and formulate the utility classes that are congruent with our SD relations. This work brings a message that some results of discrete SD cannot be generalized directly from continuous SD. We characterize the difference between discrete and continuous fractional-order SD, as well as the way to handle them.
On the Soundness of XAI in Prognostics and Health Management (PHM)
Authors: Solís-Martín David , Galán-Páez Juan , Borrego-Díaz Joaquín
Published: March 2023

The aim of Predictive Maintenance, within the field of Prognostics and Health Management (PHM), is to identify and anticipate potential issues in the equipment before these become critical. The main challenge to be addressed is to assess the amount of time a piece of equipment will function effectively before it fails, which is known as Remaining Useful Life (RUL). Deep Learning (DL) models, such as Deep Convolutional Neural Networks (DCNN) and Long Short-Term Memory (LSTM) networks, have been widely adopted to address the task, with great success. However, it is well known that this kind of black box models are opaque decision systems, and it may be hard to explain its outputs to stakeholders (experts in the industrial equipment). Due to the large number of parameters that determine the behavior of these complex models, understanding the reasoning behind the predictions is challenging. This work presents a critical and comparative revision on a number of XAI methods applied on time series regression model for PM. The aim is to explore XAI methods within time series regression, which have been less studied than those for time series classification. The model used during the experimentation is a DCNN trained to predict the RUL of an aircraft engine. The methods are reviewed and compared using a set of metrics that quantifies a number of desirable properties that any XAI method should fulfill. The results show that GRAD-CAM is the most robust method, and that the best layer is not the bottom one, as is commonly seen within the context of Image Processing.
Echoes of the 2013–2015 Marine Heat Wave in the Eastern Bering Sea and Consequent Biological Responses
Authors: Belkin Igor M. , Short Jeffrey W.
Published: March 2023

We reviewed various physical and biological manifestations of an unprecedented large-scale water temperature anomaly that emerged in the Northeast Pacific in late 2013. The anomaly dubbed “The Blob” persisted through 2014-2016, with some signs of its persistence through 2017-2018 and a possible reemergence in 2019. The tentative timeline of The Blob’s successive appearances around the Northeast Pacific is suggestive of its advection by currents around the Gulf of Alaska, along the Aleutians, into the Bering Sea, and eventually to the Bering Strait. During the initial phase of The Blob’s development in 2013-2014, advection along the Polar Front might have played a certain role. The extreme persistence and magnitude of The Blob resulted in numerous and sometimes dramatic ecosystem responses in the eastern Bering Sea. The multi-year duration of The Blob might have preconditioned the Bering Sea for the record low seasonal sea ice extent during the winter of 2017-2018 and disappearance of the cold pool in 2016 and 2018 that profoundly affected zooplankton, invertebrates, fishes, sea birds, and marine mammals. Comparison of time-series of population responses across trophic levels suggests that The Blob lowered primary production during spring, increasing small copepod production and jellyfish, and reducing energy transfer efficiently to higher trophic levels. While the Bering Sea’s water temperature, seasonal sea ice, and cold pool seem to return to the long-term mean state in 2022, it remains to be seen if the Bering Sea ecosystem will completely recover. The two most likely alternative scenarios envision either irreversible changes or hysteresis recovery.
Modernleşme, Oryantalizm ve Mısır’da On Dokuzuncu Yüzyıl İslam Düşüncesinin Seyri
Authors: SOMUNCUOĞLU Ecehan
Published: March 2023

Bu çalışma, on dokuzuncu yüzyılda Avrupa’nın hegemon bir güç olarak yükselişini, adına modernleşme denilen süreci ve on dokuzuncu yüzyılda İslam düşüncesinin seyrini incelemektedir. Osmanlı sistemi içinde olmasına rağmen Batı Avrupa’nın siyasal, ekonomik ve sömürgeci gücüyle ilk karşılaşan Müslüman ülkesi olarak Mısır, hızlı ve keskin bir modernleşme sürecini deneyimlemiştir. 1798’de başlayan ve üç yıl süren Fransa’nın Mısır’ı işgali, oryantalizm açısından da bir kırılma anına işaret etmektedir. Avrupa modernitesi arka planına dayalı olarak Mısır tarihi hakkında ayrıntılı bilimsel araştırmalar bu işgal ile büyük bir birikime ulaşmış, oryantalizme yönelik yirminci yüzyıla hakim olan eleştirel söylem için de başlangıç olmuştur. Avrupa’nın ekonomik ve askeri müdahalesine karşı canlı bir tartışma ve sorgulama dönemini ifade eden on dokuzuncu yüzyılda İslami düşünürler, İslam tarihi perspektifinden ve Mısır’a özgü koşullara dayalı olarak kültürel bir cevap arayışına girmişlerdir. Çalışmada, Batı Avrupa’da başlayıp bütün dünyaya yayılan dönüşümün kavramsal çerçevesi ele alınmış, bu doğrultuda on dokuzuncu yüzyılda İslam düşüncesinde yenilik ve süreklilik unsurlarının mahiyeti tartışılmıştır.
Efficacy of a Modified Cocktail for Periarticular Local Infiltration Analgesia in Total Knee Arthroplasty
Authors: Wang Qiuru , Zhao Chengcheng , Hu Jian , Ma Ting , Yang Jing , Kang Pengde
Published: March 2023

Background:

Periarticular local infiltration analgesia (LIA) is largely utilized for controlling pain after total knee arthroplasty (TKA). The present work aimed to assess the efficacy of a modified LIA cocktail for patients undergoing TKA.

Methods:

Magnesium sulfate (MgSO4) and sodium bicarbonate (NaHCO3) were added to a conventional LIA cocktail comprising ropivacaine, epinephrine, and dexamethasone. After the safety of this modified cocktail was tested in rats, its efficacy and safety were evaluated in a prospective, double-blinded study including 100 individuals randomized to receive periarticular infiltration of the modified cocktail or a conventional cocktail. The primary outcome was postsurgical use of morphine hydrochloride for rescue analgesia. Secondary outcomes were the time until the first rescue analgesia, postsurgical pain (on a visual analog scale [VAS]), functional recovery (assessed by range of knee motion and ambulation distance), time to discharge, and complication rates.

Results:

Adding NaHCO3 to the local anesthetics caused some instantaneous precipitation in all cases. Administering the modified cocktail to rats did not obviously damage the injected area of the nerve or surrounding tissues. Administration of the modified cocktail to patients was associated with markedly reduced postsurgical morphine use in the initial 24 hours (4.2 ± 5.0 versus 14.6 ± 8.9 mg, p < 0.001), reduced total morphine use (9.8 ± 8.4 versus 19.6 ± 11.4 mg, p < 0.001), prolonged time to the first rescue analgesia, lower VAS pain scores at rest and during motion at 12 and 24 hours following the operation, better functional recovery on postoperative days 1 and 2, and a shorter hospital stay. The modified and conventional cocktail groups had similar rates of complications.

Conclusions:

The present modification of a conventional cocktail significantly prolonged analgesia and reduced opioid consumption, which may substantially improve pain control in arthroplasty.

Level of Evidence:

Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Comparison of Spinal Mobility in Professional Musicians With and Without Pelvic Girdle Pain
Authors: Büyük Alime , Aksu Neriman Temel , Demir Erdem , Yağışan Nihan , Sarıkçıoğlu Levent
Published: March 2023

BACKGROUND: Prolonged sitting and performance hours in musicians may lead to an increased risk of musculoskeletal pain around the spine and pelvis. This situation may lead to an asymmetry of spinal segments, which in turn may correlate with muscle contractions around the lumbopelvic
area and can lead to musculoskeletal pelvic girdle pain. The aim of this study was to investigate the segmental mobility of the vertebral column in two groups of musicians, those with and without pelvic girdle pain. METHODS: This study included 45 musicians who played their instrument for
at least 10 years. Musicians were divided into two groups depending on if they had pelvic girdle pain or not. Spinal mobility was evaluated by a hand-held computer-assisted device called the Spinal Mouse system, and pelvic girdle pain assessments were evaluated using orthopedic tests including
the active straight leg raise (ASLR), flexion abduction external rotation (FABER), pelvic pain provocation (P4), and long dorsal ligament palpation (LDL). RESULTS: The current study found no significant differences in the thoracic, lumbar, and sacral curves in the trunk flexion tests between
musicians with and without pelvic girdle pain (p=0.28, 0.54, and 0.63). However, analysis of spinal mobility revealed that musicians with pelvic pain had significant limitations of spinal flexion mobility, mainly in the thoracolumbar region in the sagittal plane (p=0.02 and 0.01). CONCLUSİONS:
This study revealed a significant correlation between pelvic girdle pain and limitations of segmental spinal flexion mainly in the thoracolumbar region of the sagittal plane in musicians. A lack of spinal mobility appears to be prevalent among musicians with pelvic girdle pain.
Factors Associated with Musculoskeletal Pain Among Music Students in Iran
Authors: Akbari-Chehrehbargh Zahra , Tavafian Sedigheh Sadat , Akhshabi Majid , Badi Faezeh Moeini
Published: March 2023

BACKGROUND: Playing-related musculoskeletal pain is common among music students. We aimed to assess the prevalence of musculoskeletal pain and the factors associated with the presence of musculoskeletal pain among music students in public music conservatories in Tehran, Iran. METHODS:
Participants included 383 music students, age 12–18 years, from Tehran, Iran. A cross-sectional study was performed from October to November 2021 through convenience sampling. Demographic characteristics and musculoskeletal pain were collected using a self-report questionnaire, the Numerical
Rating Scale, and the Nordic Body Map questionnaire, respectively. Postural behavior of participants was assessed using the Rapid Entire Body Assessment checklist. RESULTS: In the convenience sample, 59.3% of music students reported at least one symptomatic musculoskeletal pain in the last
week. Female gender (OR 2.34, 95% C:1.37–3.99, p<0.001), age (OR 1.66, 95% C:1.08–2.54, p<0.001), postural behavior (OR 1.07, 95% CI 0.81–1.39, p<0.001), and duration of playing (OR 0.97, 95% CI 0.95–0.99, p<0.001) were significantly associated with the
playing-related musculoskeletal pain. History of playing and instrument type had no relationship to pain. DISCUSSION: The main risk factors associated with playing-related musculoskeletal pain in music students were the participants’ characteristics (female gender and age), postural
behavior, and playing duration. The findings support the need to design educational programs for music students in order to prevent playing-related musculoskeletal pain.
Preliminary Investigation of Perceived Sound Quality for High-Fidelity Premolded Hearing Protection Devices
Authors: Zaccardi Tess A , Portnuff Cory DF , Le Prell Colleen G
Published: March 2023

High-fidelity premolded earplugs (HiFi HPDs) are designed to provide relatively uniform attenuation across frequencies. The primary goal of this study was an exploratory analysis of relationships between attenuation and perceptions of sound quality. Participants were 16 adults tested
using commercial HiFi HPDs marketed for use at recreational music events. Survey responses did not reveal statistically significant differences in perceived sound quality across HiFi HPD brands. However, increases in music quality ratings were correlated with decreases in average attenuation
at 3, 4, and 6 kHz and increasing uniformity of attenuation. The correlations were weak, however, explaining only about 15% of the variance. The data suggest listeners may prefer HiFi HPDs that provide more uniform sound attenuation at frequencies from 0.25 to 4 kHz and less attenuation from
3 to 6 kHz. The data are consistent with existing suggestions that HiFi HPDs with moderate but uniform attenuation may be preferred by those listening to music.
New Structures of Continuous Functions
Authors: Pattanashetti B.R. , Patil P.G.
Published: March 2023

Continuous functions are novel concepts in topology. Many topologists contributed to the theory of continuous functions in topology. The present authors continued the study on continuous functions by utilizing the concept of gpα-closed sets in topology and introduced the concepts of weakly, subweakly and almost continuous functions. Further, the properties of these functions are established.
A Pilot Demonstration of Flaring Gas Recovery during Shale Gas Well Completion in Sichuan, China
Authors: Xue Ming , Li Xingchun , Cui Xiangyu , Cheng Xin , Liu Shuangxing , Xu Wenjia , Wang Yilin
Published: March 2023

As one of the largest emitters in the world, the oil and gas industry needs to apply more effort to greenhouse gas (GHG) reduction. Methane, as a potent GHG, could largely determine whether natural gas could serve as a bridging energy toward a sustainable future. In the past decade, oil and gas companies in China have significantly enhanced casing gas recovery and reduced large volume flaring (>2×104 m3/d). However, the remaining low- to mid-volume flaring gas was left for further recovery. Shale gas production in China has met a surge in the number of drilling wells. Those new wells were characterized by a relatively low gas production rate (<1×106 m3/d) in comparison with shale gas wells in the US. As a result, flaring gas during well completion needs to be recycled or used to enhance the gas recovery rate. In this study, we carried out a pilot demonstration project of flaring gas recovery to reduce GHG emissions in the Weiyuan shale gas region in Sichuan Province, China. We adopted the technical route of dehydration and natural gas compression. The recycled natural gas was transformed into compressed natural gas (CNG) and transported to the nearest CNG station for further use. The inlet gas pressure was between 2.85 and 5.82 MPa, and the outlet pressure was kept stable at around 20 MPa to meet the standard of CNG. The manufactured device also showed sound flexibility with the recovery rate between 523.22 and 1224.38 m3/h, which was 28–157% of the designed capacity. The combination of the molecular sieve with high capacity, post low-pressure dehydration, and the application of hydraulic piston in the compression system have guaranteed the equipment to meet the designed performance. The equipment applied in the pilot demonstration has well matched with the local transportation, gas composition, and surface engineering of the well completion. It has the potential of popularization and application in the shale gas tight gas regions in China. Other technical routes, such as small-scale gas to chemicals or natural gas hydrate, should be considered for industrial application for gas flowing rate less than 2×104 m3/d to ensure a further drive down of methane emission along the value chain.
Predicting Online Fraudulent Transaction Using Machine Learning
Authors: T.P Rani , K. Suganthi , Saravanan Magilan , Sahu Ashish Kumar , Sagayam K.Martin , Pramanik Sabyasachi
Published: March 2023

The authors have requested that this preprint be removed from Research Square.
Safety and efficacy of perioperative FLOT regimen in Japanese patients with gastric, esophagogastric junction, or esophageal adenocarcinoma: A single-institution experience
Authors: Takei Shogo , Kawazoe Akihito , Komatsu Masaru , Sato Kazuma , Mishima Saori , Kotani Daisuke , Akimoto Eigo , Yura Masahiro , Sakamoto Naoya , Sakashita Shingo , Kuwata Takeshi , Kojima Takashi , Fujita Takeo , Kinoshita Takahiro , Shitara Kohei
Published: March 2023

Background
Although the common treatment strategy for localized gastric cancer in Japan is gastrectomy followed by adjuvant chemotherapy, several randomized studies in non-Japanese populations have established perioperative chemotherapy as the standard treatment for localized gastric or gastroesophageal junction adenocarcinoma. Therefore, we have implemented this strategy in our institution.
Methods
We retrospectively reviewed the medical records of patients with resectable gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma who had received perioperative FLOT from February 2020 to November 2021.
Results
In this study, a total of 48 patients were analyzed, with a median age of 70 years (range: 29–82). At the time of diagnosis, 46 patients (95.8%) had T3 or higher-grade primary lesions, and 43 (90%) had lymph node metastasis. Seven patients had resection before completing four cycles of preoperative chemotherapy, and 37 of 48 (77.1%) completed four cycles with 35 of these receiving radical resection. Among the 42 patients who had radical resection after FLOT, 41 (97.6%) achieved R0 resection, including 4 (9.5%) with a pathological complete response. After resection, 29 patients (60.4%) received at least one cycle of postoperative FLOT, and 20 (41.7%) completed eight cycles of FLOT treatment. Chemotherapy-related adverse events of Grade 3 or higher occurred during the pre- and postoperative FLOT in 41 patients (85.4%), including leukopenia (52.1%), neutropenia (83.3%), febrile neutropenia (8.3%), and anorexia (10.4%). No treatment-related deaths occurred.
Conclusions
These findings were comparable to those in the pivotal FLOT 4 study, suggesting acceptable feasibility of the FLOT regimen in Japanese clinical practice.
Template-based genome editing directed by the SviCas3
Authors: Tong Wang-Yu , Yu Zhong-Fan , Li Yong , Ye Shou-Dong , Yong De-Xiang , Wang An-Jing , Tang Yan-Yan , Xu Xin , Qiu Cai-Hua , Yang Xing-Wang , Xia Ting-Ting , Li Mei-Li , Liu Qing-Yang , Zhu Si-Qi , Zhang Yan , Cao Su-Li , Sun Yan , Li Xue
Published: March 2023

RNA-guided genome editing based on the CRISPR-Cas system is currently the most effective genome editing technique. Here, we report that SviCas3 from the subtype I-B-Svi Cas system in Streptomyces virginiae IBL14 is an RNA-guided and DNA-guided DNA endonuclease suitable for the gene and/or base editing of prokaryotic and eukaryotic cell genomes. The genome editing efficiency of SviCas3 guided by DNA was no less than that of SviCas3 guided by RNA. It should be noted that no off-target effects or indel-formation were detected in targeted sequencing. In particular, t-DNA, as a template and a guide, does not require a proto-spacer-adjacent motif, demonstrating that CRISPR, as the basis for crRNA design, is not required for SviCas3-mediated gene and base editing. This discovery will provide important tools for the creation and modification of living things and the treatment of human genetic diseases, and will usher in a new era of DNA-guided genome editing.
A computational model of epidemic process with three variants on a synthesized human interaction network
Authors: seprianus seprianus , Nuraini Nuning , Saputro Suhadi Wido
Published: March 2023

Virus mutations give rise to new variants that cause multiple waves of pandemics and escalate the infected number of individuals. The spread of virus variants on a network could reflect how the disease continues to spread in a human population for a long time and becomes a pandemic. In this paper, we develop a mathematical model by paying attention to the microscopic process of disease spreading in a human interaction network by adding variants in the middle of spreading. We also generate a synthesized human interaction network with a certain structure such as the average number of degrees and the frequency of contacts to describe human interaction in a population. Then, we randomly choose a small number of individuals infected by the original virus at the initial condition and add a small number of individuals infected by other variants after a certain time lag. Unlike the SIR classic models, we do not use a recovery rate in this study. Instead, we use the time when an individual is infected for the first time and the infection period to move an infected individual to a recovered state. Then, we will show several different examples of synthesized human interaction networks to describe how the structures determine epidemic dynamics.
Full-length transcriptomics study of Ustiloxins-induced hepatocyte injury
Authors: Zhang Guomei , Zhou Xuming , Li Han , Liu Shanshan , Sun Lihua
Published: March 2023

Background: Ustiloxins is a mycotoxin produced by the metabolism of Rice false smut. Studies have shown that Ustiloxins may be toxic to animals, but there is still a lack of toxicological evidence. The liver, as the main organ for the biotransformation of foreign chemicals, may be the direct target organ of Ustiloxins toxicity.
Results: In this study, we found that Ustiloxins inhibited BNL CL.2 cells in a dose-and time-dependent manner. In addition, scanning electron microscope observation showed that the cell membrane of the experimental group was damaged, with the appearance of apoptotic bodies. We analyzed the key action targets of Ustiloxins on hepatocyte injury using full-length transcriptomics. A total of 1099 differentially expressed genes were screened, of which 473 genes were up-regulated, and 626 genes were down-regulated. The selected genes were verified using qRT-PCR, and the results were consistent with those of full-length transcriptomics, proving the reliability of full-length transcriptomics. Besides, we also found that the expression of MCM7 and CDC45 in BNL CL.2 cells treated with Ustiloxins decreased, and the expression of CCl-2, CYP1b1, CYP4f13, and GSTM1 increased according to qRT-PCR. Moreover, the ROS and GSH levels were significantly increased in cells exposed to 5, 10, and 20 μg/mL of Ustiloxins.
Conclusions: Ustiloxins could change CYP450 and GST-related genes, affect DNA replication and cell cycle, and lead to obvious oxidative stress and liver cell injury.
Chinese Abdominal tuina on metabolic sydrome patients with heat stagnation of liver and stomach sydrome: study protocol for a randomized parallel controlled trial
Authors: Mao Xinxin , Shi Shuqing , Wang Yajiao , Gao Xiya , Zhao Lu , Wu Huaqin , Song Qingqiao , Zhang Bingxuan
Published: March 2023

Introduction The incidence of Metabolic Syndrome (MetS) continues to rise and has become a serious health hazard worldwide. Abdominal tuina treatment for MetS has the advantages of high safety and strong patient compliance, but there is still a lack of high-quality evidence-based medicine evidence.While,the study of the pathogenesis of MetS has progressed slowly, and its initiating factors are still unknown, so it is crucial to explore its mechanisms.
Methods and analysis This study was a randomized parallel controlled trial. One hundred and forty-four patients with metabolic sydrome patients with heat stagnation of liver and stomach sydrome were included, and the patients were randomly divided into a experimental group and a control group in a 1:1 ratio according to the random assignment principle, and the treatment course was 4 weeks in both groups. The control group was treated with conventional basic treatment based on lifestyle intervention; the experimental group was treated with abdominal massage (fifteen minutes) and acupoint pressure (thirty seconds/acupoint) on basis of the control group, 3 times/week, 12 times in total. Indicators were collected at different time points of the study, the results were analyzed and the safety was evaluated. Follow-up visits were performed 30 days after the end of the trial to assess the subjects' condition. The aim of this study was to evaluate the efficay and safety of abdominal tuina on the the early metabolic syndrome(MetS) patients with liver and stomach heat rentention type, and to provide new method and high quality evidence-based medical evidence for the prevention and treatment MetS.And to preliminary explore the action targets of abdominal tuina to improve MetS, provide theoretical basis for further mechanism exploration and direction for enriching the connotation of tuina theory.
Trial registration ClinicalTrials.gov, ChiCTR2200057997, Registered on 26 March 2022.
Analysis of the potential biological mechanisms of diosmin against renal fibrosis based on network pharmacology and molecular docking approach
Authors: Zhao Wen-Man , Wang Zhi-Juan , Shi Rui , Zhu Yvyv , Li Xun-Liang , Wang De-Guang
Published: March 2023

BackgroundInterstitial fibrosis is involved in the progression of various chronic kidney diseases and renal failure. Diosmin is a naturally occurring flavonoid glycoside that has antioxidant, anti-inflammatory, and antifibrotic activities. However, whether diosmin protects kidneys by inhibiting renal fibrosis is unknown.MethodsThe molecular formula of diosmin was obtained, targets related to diosmin and renal fibrosis were screened, and interactions among overlapping genes were analyzed. Overlapping genes wereused for gene function and KEGG pathway enrichment analysis.TGF-β1 was used to induce fibrosis in HK-2 cells, and diosmin treatment was administered. The expression levels of relevant mRNA were then detected.ResultsNetwork analysis identified 295 potential target genes for diosmin, 6828 for renal fibrosis, and 150 hub genes. Protein–protein interaction network results showed that CASP3, SRC, ANXA5, MMP9, HSP90AA1, IGF1, RHOA, ESR1, EGFR, and CDC42 were identified as key therapeutic targets. GO analysis revealed that these key targets may be involved in the negative regulation of apoptosis and protein phosphorylation. KEGG indicated that pathways in cancer, MAPK signaling pathway, Ras signaling pathway, PI3K-Akt signaling pathway, andHIF-1 signaling pathway were key pathways for renal fibrosis treatment. Molecular docking results showed that CASP3, ANXA5, MMP9, and HSP90AA1 stably bind to diosmin. Diosmin treatment inhibited the protein and mRNA levels of CASP3, MMP9, ANXA5, and HSP90AA1.Network pharmacology analysis and experimental results suggest that diosmin ameliorates renal fibrosis by decreasing the expression of CASP3, ANXA5, MMP9, and HSP90AA1.ConclusionsDiosmin has a potential multi-component, multi-target, and multi-pathway molecular mechanism of action in the treatment of renal fibrosis. CASP3, MMP9, ANXA5, and HSP90AA1 might be the most important direct targets of diosmin.
MSC.sensor: capturing cancer cell interactions with stroma for functional profiling
Authors: Huang Yun , Drakul Aneta , Sidhu Jasmeet , Rauwolf Kerstin , Kim James , Bornhauser Beat , Bourquin Jean-Pierre
Published: March 2023

Mesenchymal stromal cells (MSCs) contribute to the microenvironment regulating normal and malignant hematopoiesis, and thus may support subpopulations of cancer cells to escape therapeutic pressure. Here, we engineered bone marrow MSCs to express a synthetic CD19-sensor receptor to detect and display interacting primary CD19+ leukemia cells in coculture. This implementation provides a versatile platform facilitating ex vivo drug response profiling of primary CD19+ leukemia cells in coculture with high-sensitivity and scalability.
Intra-arterial Versus Intravenous Chemoradiotherapy for Maxillary Sinus Squamous Cell Carcinoma
Authors: Iuchi Hiroyuki , Ohori Junichiro , Haraguchi Megumi , Toge Sakiko , Yamashita Masaru
Published: March 2023

Background
The surgical treatment of maxillary sinus cancer may be declined by patients from a functional and cosmetic point of view. Treatment methods other than surgery include intra-arterial and intravenous chemoradiotherapy. The purpose of this study was to evaluate the utility of intra-arterial chemoradiotherapy (RADPLAT) compared with that of intravenous chemoradiotherapy for patients with squamous cell carcinoma of the maxillary sinus (MS-SCC).
Methods
We retrospectively reviewed the records of 22 patients with MS-SCC histologically confirmed from January 2008 to January 2021. The patients underwent RADPLAT or intravenous chemoradiotherapy. Cumulative survival was analyzed using the Kaplan-Meier method; we specifically analyzed overall survival (OS), progression-free survival (PFS), and locoregional recurrence-free survival (LRFS).
Results
One patient (5%) was diagnosed with T2 disease, 5 (23%) with T3 disease, and 16 (72%) with T4 disease. The median follow-up time was 29.5 months. Seventeen patients underwent RADPLAT, and 5 patients underwent intravenous chemoradiotherapy with Cisplatin (CDDP). Nine patients each experienced grade 3 toxicity during the two treatments. The 3-year OS, PFS, and LRFS rates of patients who underwent RADPLAT were 82%, 65%, and 77%, respectively. The 3-year OS, PFS, and LRFS rates of patients who underwent intravenous chemoradiotherapy with CDDP were 60%, 20%, and 20%, respectively. Only the LRFS rate was statistically significant (p=0.029).
Conclusions
This study suggests that RADPLAT is more useful than intravenous chemoradiotherapy in terms of local control in treating MS-SCC patients who refuse surgery.
WITHDRAWN: Prussian blue analogue derived nitrogen‒carbon mixed metal sulfides heterostructure for asymmetric supercapacitors
Authors: Wu Yuan , Chen Xudong , Zhou Yang , Wu Cunqi , Li Lei , Xu Zhenming , Zhang Xiaogang , Tong Hao
Published: March 2023

Prussian blue analogues (PBAs) have the advantages of stable electrochemical performance and long service life when used as energy storage materials due to their face‒centered cubic structure. Here, Ni‒Co Prussian blue analogue (PBA) nano units have been utilized as precursor to prepare corresponding metal sulfide derivatives, which inherited the structural properties of the precursor. This unique structural exposes more reaction sites and the generation of a small amount of nitrogen-doped carbon that enhances charge transfer. This cube structure has a buffer effect on the stress of the active substance during charging and discharging. The CoS2/Ni3S4‒N‒C provides a capacitance of 817 C g‒1 at 3 A g‒1 and there is still 556 C g‒1 at 20 A g‒1. Furthermore, CoS2/Ni3S4‒N‒C electrode yields outstanding cycle stability (98.2% capacitance retention at 10,000 cycles). An asymmetric supercapacitor (ASC) device consisting of CoS2/ Ni3S4‒N‒C and activated carbon electrodes have an energy density of 40 Wh kg‒1, and a retention rate of 103.7% for 10,000 cycles at 10 A g‒1, presenting excellent cycle stability. The electron properties of Co2NiO4 and CoS2/Ni3S4 − N−C are compared by density functional theory (DFT). CoS2/Ni3S4 − N−C detects more DOS near the Fermi level, leading to larger charge accumulation, indicating that the electron conductivity of the heterojunction is much higher than that of the oxide, and eventually faster reaction kinetics can be obtained.
Fréchet-Urysohn property of quasicontinuous functions
Authors: Osipov Alexander
Published: March 2023

The aim of this paper is to study the Fréchet-Urysohn property of the space Qp(X,R) of real-valued quasicontinuous functions, defined on a Hausdorff space X, endowed with the pointwise convergence topology.
It is proved that under Suslin's Hypothesis, for an open Whyburn space X, the space Qp(X,R) is Fréchet-Urysohn if and only if X is countable. In particular, it is true in the class of first-countable regular spaces X.
In ZFC, it is proved that for a metrizable space X, the space Qp(X,R) is Fréchet-Urysohn if and only if X is countable.
2010 MSC: 54C35, 54C40
Clinical Efficacy of ECMO in the Treatment of AMI Complicated with Refractory CS
Authors: Qu Wenjing , Lu Andong , Pan Chenliang , Cai Weiting , Wa Yongling , Lei Peng , Hu Sixiong , Zhao Jing , Bai Ming
Published: March 2023

Objective:The aim of this single-centre retrospective study was to investigate the efficacy of extracorporeal membrane oxygenation (ECMO) in the treatment of acute myocardial infarction (AMI) complicated by refractory cardiogenic shock (CS).Background:While mechanical circulatory support (MCS) devices are widely used in reperfusion therapy, no significant reduction in mortality has been observed. ECMO is a rescue tool for patients refractory CS, with a paucity of data evaluating its efficacy in the treatment of AMI complicated with refractory CS.Methods:All consecutively enrolled patients with AMI and refractory CS admitted to the First Hospital of Lanzhou University from July 1, 2015, to October 31, 2021, were enrolled. According to the MCS device, the patients were divided into the ECMO and IABP groups. The primary outcome of our study was 30-day mortality. Secondary outcomes included perioperative mortality, 90-day mortality, renal failure requiring CRRT, life-threatening bleeding, moderate bleeding, ischaemic complications, and bacteremia.Results:A total of 81 patients, with a mean age of 62 ± 10 years, were included, 79% of them were males. Forty-four patients (54.3%) were included in the IABP group, and 37 (45.7%) were included in the ECMO group. The average lactate level was 7.05 ± 3.56 mmol/L. A total of 72.0% of patients had multivessel coronary artery disease (CAD). Compared with IABP, ECMO led to lower 30-day mortality (68.2% vs. 43.2%, χ2=8.423, P=0.004) and perioperative mortality rates (20.0% vs. 0.00%, χ2=5.877, P=0.015) but prolonged the patient's CCU (10.0 vs. 3.5, p < 0.001) and total hospital stay (13 vs. 4, p < 0.001). In the subgroup analysis of multivessel CAD, the 30-day mortality rate in the ECMO group who underwent immediate multivessel PCI was significantly lower than that in those who initially underwent PCI of the culprit lesion only (21.4% vs. 61.5%, χ2=4.402, P=0.036).Conclusion:ECMO can significantly reduce the risk of 30-day mortality and does not increase the risk of serious complications. In addition, immediate multivessel PCI with ECMO can significantly reduce 30-day mortality in patients with multivessel CAD.
Authentication of a survival nomogram for non-invasive micropapillary breast cancer
Authors: Zhang Mingkun , Qin Yuan , Hou Niuniu , Ji Fuqing , Zhang Zhihao , Zhang Juliang
Published: March 2023

Purpose
We aimed at establishing a nomogram to accurately forecast the overall survival (OS) of non-metastatic invasive micropapillary breast carcinoma (IMPC).
Methods
In the training cohort, data from 429 patients with non-metastatic IMPC were obtained through the Surveillance, Epidemiology, and End Results (SEER) database. Other 102 patients were enrolled at the Xijing Hospital as validation cohort. Independent risk factors affecting OS were ascertained using univariate and multivariate Cox regression. A nomogram was established to forecast OS at 3, 5 and 8 years. The concordance index (C-index), the area under a receiver operating characteristic (ROC) curve and calibration curves were utilized to assess calibration, discrimination and predictive accuracy. Finally, the nomogram was utilized to stratify the risk. The OS between groups was compared through Kaplan-Meier survival curves.
Results
The multivariate analyses revealed that race (p = 0.047), surgery (p = 0.003), positive lymph nodes (p = 0.027), T stage (p = 0.045) and estrogen receptors (p = 0.019) were independent prognostic risk factors. The C-index was 0.766 (95% CI, 0.682–0.850) in the training cohort and 0.694 (95% CI, 0.527–0.861) in the validation cohort. Furthermore, the predicted OS was consistent with actual observation. The AUCs for OS at 3, 5 and and 8 years were 0.786 (95% CI: 0.656–0.916), 0.791 (95% CI: 0.669–0.912), and 0.774 (95% CI: 0.688–0.860) in the training cohort, respectively. The area under the curves (AUCs) for OS at 3, 5 and 8 years were 0.653 (95% CI: 0.498–0.808), 0.683 (95% CI: 0.546–0.820), and 0.716 (95% CI: 0.595–0.836) in the validation cohort, respectively. The Kaplan-Meier survival curves revealed a significant different OS between groups in both cohorts (p༜0.001).
Conclusion
Our novel prognostic nomogram for non-metastatic IMPC patients achieved a good level of accuracy in both cohorts and could be used to optimize the treatment based on the individual risk factors.