bluuebunny/crossref_metadata_2025 huggingface dataset:
تناسق الآيات ووحدة الموضوعية في القرآن: دراسة تفسيرية تحليلية لسُوَر غافر الصَّافات والنّازعات
Authors: Toure Abdoul Karim , Norzulaili Mohd Ghazali  , Mesbahul Hoque
Published: January 2024

This study deals with one of the most important topics of interpretation of the Holy Qur'an, which is the unity of objectivity in the Holy Qur'an. Tafsīr al-Mawḍuꜥī is a type of interpretation that was not present in the works of earlier scholars and has not properly developed through the work and efforts of contemporary researchers because it still requires rooting and a methodology capable of achieving the main goals of the Qur'an as the book of guidance and a way of life for people in every era. The study aims to show that the Tafsīr al-Mawḍuꜥī is the most appropriate to follow in our contemporary era in dealing with the unity of the topics of the Qur'an or some Surahs, as it reveals one of the aspects of the miracle of the Qur’an about man, the universe, and life: the Qur'an is a comprehensive and immortal cognitive miracle. The study aims to highlight the beauty of the Holy Qur'an in its consistency and coherence of its verses with each other, as if it were one surah revealed at the same time and not over extended periods. The researchers used in this study two approaches: the inductive approach and the analytical method, where we collected in the inductive approach verses from three surahs, which are al-Ghafir, al-Saffat and al-Naziat, and then analysed them to show and prove their consistency with each other and their interdependence in a very wonderful thematic unity.
DIVERSITY AND JOB SATISFACTION WITHIN ORGANIZATIONAL CLIMATE IN KOGI STATE, NIGERIA: EXPLORING THE SCENARIO OF SMALL AND MEDIUM-SIZED ENTERPRISES
Authors: Okpebenyo Williams , Nafiu Akeem Tunde , Sule Adomokhai Simon
Published: January 2024

This study focused on diversity and job satisfaction within organisational climates, exploring the scenarios of small and medium-sized enterprises. The study explored the effects of physiological elements of employee diversity on job satisfaction at the workplace and ascertained the influence of psychological diversity climate on the job satisfaction of employees in SMEs in Kogi State. This study employed a survey research design and targeted employees who could provide insights into diversity-related situations. Both descriptive and inferential methods were employed to analyse the collected data. The study used multiple regression analyses to test hypotheses. Results showed that the age of employees has a significant negative effect on job satisfaction. As employees grow older, there is a noticeable trend towards decreasing job satisfaction, and the gender of employees was found to have an insignificant negative effect on job satisfaction, among others. The study recommends, among others, that SME owners or managers should implement age-specific support programmes aimed at addressing the changing needs and preferences of older employees to help sustain and improve their job satisfaction and that managers should conduct regular training sessions to raise awareness and sensitivity among employees regarding religious and diversity-related issues to foster a positive and inclusive work environment.
Keywords: psychological diversity climate, diversity management, job satisfaction, physiological diversity, synergetic environment
Information support for rural areas development: methodological principles of using administrative registers’ data for conducting rural population censuses
Authors: Satyr L. , Zadorozhna R. , Kepko V. , Stadnik L.
Published: January 2024

The article deals with the study of the role of the population census as the main official source of data on the population, in particular, those living in rural areas, and its main characteristics. The role of statistical data in providing information for the development of rural areas is substantiated. The demographic and socio-economic characteristics of the rural and urban population of Ukraine for the period 2000-2021 are compared. Census provides data on the number and main characteristics of the country's population based on principles of individual enumeration, simultaneity, universality, small area data and defined periodicity. From the methodological point of view, the main forms of the census are traditional, combined and register-based. The purpose of the study is to generalize methodological approaches to the register-based censuses and to analyze prerequisites for the transition from traditional to the register-based census. The study was performed on the basis of the systematic approach. Analysis, synthesis, comparison, theoretical generalization, as well as abstract-logical and historical methods as general-scientific methods of theoretical research were applied to achieve the purpose of the study.

The results obtained indicate that an administrative register is a systematic collection of unit-level data that can be updated. Population register and a dwelling register should be used in a census in order to treat it as register-based. The main advantages of the register-based census are cost reduction, better possibilities of updating data, performing census more frequently and quicker, improving data accuracy by integration of different registers information. To meet census needs, administrative data have to be complete, accurate, linkable, up-to-date, contain sufficient variables. However, so far as register data are collected for non-statistical purposes, additional measures are needed to enable their use for census purposes. These are methodological as well as legislative and technical measures. The countries of Northern Europe have accumulated the greatest experience of conducting population censuses based on administrative registers. This will be useful to the state statistics authorities of Ukraine for the statistical purposes of population accounting. Also this will allow to reduce the cost of obtaining necessary information, as well as expand the list of data for further analysis. Our research found that Ukrainian statistics started moving toward research-based census, but there is a lot of work to conduct the 2030 Census based on administrative registers data.
Key words: rural areas, rural territorial community, census, traditional census, combined census, register-based census, administrative register.
Methodological principles of analysis and forecasting of the market situation of vegetable products
Authors: Borshchyk V.
Published: January 2024

The article examines the methodological principles of the analysis and forecasting of the vegetable market situation and characterizes the main types of situational research. It is argued that the analysis of the market situation should be based on interdisciplinary and systemic approaches, as well as take into account the influence of the world market of the relevant products. The system principles of the research of the market situation are highlighted and the factors of the global, external and internal environment that affect it are identified. The components of information support for monitoring the state of demand and supply are disclosed, and the main indicators and indicators characterizing the market situation are outlined. It was concluded that the research of the market of vegetable products should be based on methodological approaches that would ensure the study of the peculiarities of the formation of the product offer and its delivery to the final consumers. The factors and features of the market of the vegetable products, which must be taken into account when studying its conjuncture, are systematized. An algorithm for researching the market of vegetable products is proposed, which involves researching its market conditions, determining the capacity and purchasing behavior of consumers. It has been proven that when conducting market research of vegetable products, it is expedient to calculate the level of self-sufficiency for certain types of vegetable products. The author emphasized that when analyzing the product offer on the market of open ground vegetables, it is expedient to determine the type of competitive relations that dominate this market, and the approaches and indicators characterizing the intensity of competition are highlighted. The list of indicators that should be used to establish the regional characteristics of the vegetable market and the characteristics of the effect of its functioning, which is manifested on the basis of econommeneg.btsau.edu.ua market, economic and social efficiency, is outlined. The task of marketing analysis of the vegetable market is revealed, which involves the calculation of its potential and actual capacity and is the basis for developing forecasts of its situation. The proposed algorithm for researching the vegetable market is the portfolio analysis based on which it is possible to reasonably determine the most profitable and promising segments of the market by types of products.
Key words: market of vegetable products, research of the market situation, supply and demand, intensity of competition, marketing analysis.
The role of potential foreign investors in the development of the economy of Ukraine in the conditions of war
Authors: Verniuk N. , Diachenko M.
Published: January 2024

The article examines the essence of investments and their role in the economic development of Ukraine.
The main factors and obstacles that negatively affect the development of investment activities in Ukraine are characterized. The priority areas of investment development were determined and the main factors influencing the level of business activity and investment environment in Ukraine were determined based on the results of a survey of international and Ukrainian companies.
The main positive steps of the government in the direction of creating qualitatively new business conditions and activation of investment activity are considered. It has been established that for a satisfactory state of investment activity of Ukrainian enterprises in wartime conditions, it is necessary to carry out a number of measures on the part of the state to eliminate large-scale corruption, improve the judicial system, etc.
The priority directions and spheres of investment activities, in particular in the development of the agrarian sector, have been determined. There is a well-founded need to create and implement promising investment programs for the development of agricultural enterprises, as well as support innovative development of all branches of the country's economy in order to eliminate the negative consequences of Russian aggression, stabilize and develop the economy of Ukraine.
Key words: investment, investment activity, investment environment, investment policy, investment development.
Asociación entre alimentación y parasitosis intestinales en una comunidad rural de Ecuador: Un análisis epidemiológico
Authors: Robalino Flores Ximena del Rocío , Mora Gaibor Daniela Elizabeth , Luzón Ríos Dayanna Thalía , González Ramírez Luisa Carolina
Published: January 2024

Introducción. Las infecciones enteroparasitarias representan un problema de la salud pública, por su elevada prevalencia en países en desarrollo. La población rural está expuesta al contagio debido a la pobreza, falta de agua potable y precarias condiciones higiénico-sanitarias. Objetivo. El propósito de esta investigación fue evaluar la asociación entre los alimentos ingeridos y los enteroparásitos diagnosticados en residentes de la comunidad de Cuatro Esquinas, San Andrés, Guano, Chimborazo. Metodología. Estudio descriptivo, de campo, transversal y prospectivo. El muestreo fue no probabilístico en bola de nieve. La información fue recopilada mediante encuestas y diagnóstico coproparasitológico (examen directo, Ritchie, Kato-Katz, Ziehl-Neelsen).  Se evaluó a un total de 49 individuos (4 y 88 años), de sexo masculino (19) y femenino (30), quienes entregaron muestras fecales. Resultados.  Todos los individuos estaban infectados, hubo mayor prevalencia de protozoos (100%) que de helmintos (4,08%) (X2=82,653; p<0,0001). Los parásitos predominantes fueron Blastocystis sp. (77,55%), Endolimax nana (67,35%) y Entamoeba coli (36,73%) (X2=170,85; p<0,0001), y el único helminto detectado fue Ascaris lumbricoides (4,08%). El estudio estadístico no comprobó asociación significancia entre los alimentos de consumo declarados (verduras, frutas, alimentos de origen animal, granos) y los parásitos detectados en las personas. Sin embargo, el estudio epidemiológico destaca que 83,67% de los individuos permanecen con las manos sucias (X2=22,837; p<0,0001) y que el 69,3% de los individuos consumen alimentos en puestos ambulantes (X2=53,327; p<0,0001). Conclusión. Se concluye que los alimentos de consumo declarados por los participantes no son vehículos de enteroparásitos, pero debe considerarse como factores asociados a la transmisión que la mayor parte de las personas permanecen con las manos sucias y consumen alimentos en puestos ambulantes. Área de estudio general: Laboratorio Clínico. Área de estudio específica: Parasitología. Tipo de estudio:  Artículos originales.
Rancang Bangun Panel Auto Transfer Switch (ATS) Pada Sistem Hybrid PLN – Panel Surya Berbasis Timer Switch
Authors: Tahir M. Ashar , Irsan B Muhammad
Published: January 2024

Penelitian ini bertujuan untuk merancang dan mengimplementasikan panel Auto Transfer Switch (ATS) pada sistem hybrid PLN - panel surya berbasis timer switch. Penelitian ini mengumpulkan data arus listrik dan tegangan dari PLN dan panel surya saat digunakan dengan beban lampu 5, 10, 15, 20, dan 25 watt. Hasil penelitian menunjukkan bahwa arus listrik dari PLN dan panel surya bervariasi dengan beban lampu yang digunakan. Arus listrik dari PLN adalah 0,03 A, 0,06 A, 0,09 A, 0,12 A, dan 0,15 A, dengan tegangan terhitung sebesar 166 Volt. Sementara itu, arus listrik dari panel surya adalah 0,03 A, 0,06 A, 0,09 A, 0,13 A, dan 0,16 A, dengan tegangan terhitung sebesar 166 Volt, 153 Volt, dan 156 Volt. Selain itu, penelitian ini juga memperhitungkan jeda waktu perpindahan dari PLN ke panel surya, yang memiliki nilai sebesar 1,60 detik. Penghematan yang dapat dicapai dengan menggunakan sistem hybrid ini adalah sebesar Rp. 19.468. Dengan menggunakan panel ATS yang dirancang dan diimplementasikan dalam sistem hybrid ini, pengguna dapat secara otomatis beralih antara sumber daya PLN dan panel surya berdasarkan waktu yang telah ditentukan. Hal ini dapat membantu pengguna mengoptimalkan penggunaan energi dan menghemat biaya listrik.
A Case of Retinal Vasculitis, Uveitis in Myelin Oligodendrocyte Glycoprotein Antibody Associated Optic Neuritis
Authors: Cho Young-Ri , Ahn Sung-Hyun , Cho Nam-Chun , Lee Haeng-Jin
Published: January 2024

Purpose: To report a case of recurrent optic neuritis with uveitis in a patient with myelin oligodendrocyte glycoprotein (MOG)- associated disease.Case summary: A 16-year-old female presented with left eye hyperemia, glare, and headache. The best corrected visual acuity was 1.2 in both eyes with a left relative afferent pupillary defect. Cells in the anterior chamber, optic disc edema, and subretinal fluid were present, and the distal optic nerve was enhanced on orbital magnetic resonance imaging. Although it improved with steroid treatment, it recurred 3 times in 9 months. At the second recurrence, her visual acuity was reduced to light perception, but she responded well to steroids. During the third recurrence, she visited our hospital for the first time and improved with steroid treatment. However, 18 months after treatment, optic neuritis, uveitis, and macular edema occurred, so oral steroids and eye drops were maintained. Serum anti-MOG antibody came out positive, and at the last visit, visual acuity of 1.2 in the left eye and visual function were maintained well.Conclusions: MOG antibody disease (MOGAD) frequently recurs and invades various structures of the eye and various clinical manifestations have been reported. Therefore, if optic neuritis is accompanied by inflammation of the anterior chamber and retinal vessels, the possibility of MOGAD should be considered.
Pengaruh Motivasi Entertainment, Pass Time, dan Self Presentation Terhadap Hubungan Parasosial Penonton Netflix
Authors:   Universitas Padjadjaran, Aulia Aaliyah , Suminar Jenny Ratna ,   Universitas Padjadjaran, Prasanti Ditha ,   Universitas Padjadjaran
Published: January 2024

The Netflix platform is no longer a stranger today, especially for film lovers during the Covid-19 pandemic. This phenomenon is interesting to study, in terms of knowing the influence of entertainment motivation, pass time and self-presentation on parasocial relationships in Netflix platform streaming users during the Covid-19 pandemic using the uses and gratfications theory as a framework and the initial basis for this research. The data used in this study were collected using a questionnaire with the help of Google Form to facilitate the distribution of questionnaires to Netflix users. Research sampling uses a non-probability sampling method, with a derivative of the convenience sampling method to increase data accuracy. The population in this study are Netflix users in Indonesia. The required sample size is calculated using the help of the G Power application. After obtaining 216 respondents, the data needed was then analysed using multiple linear regression tests on IBM SPSS. The results of this study show that entertainment motivation has a significant effect of 0.271 while self presentation motivation has a significant effect of 0.966 on the parasocial relationships of Netflix viewers during the Covid-19 pandemic. However, pass time motivation has no influence on the parasocial relationship of Netflix viewers during the Covid-19 pandemic.
Personal Political Branding: Strategi Kampanye Ganjar Pranowo Untuk Pilpres 2024 di Social Media Twitter
Authors:   Universitas Muhammadiyah Yogyakarta, Hadjira Sitti , Suranto Suranto ,   Universitas Muhammadiyah Yogyakarta
Published: January 2024

In this digital age, social media has become a powerful platform to communicate and influence public opinion. A critical aspect of using social media is its ability to strengthen political branding, which is how a politician or political party builds their image and identity in the eyes of the public. Political branding refers to creating a political image and identity for a candidate, political party, or political movement in society. Ganjar Pranowo, as the Governor of Central Java, utilizes Twitter as a medium to strengthen the value of political branding. This research aims to explain Ganjar Pranowo's political branding strategy through his Twitter social media account. This research uses a qualitative method; then, the researcher uses the Nvivo 12Plus application to analyze the data. The results of this study show that political branding efforts made by Ganjar Pranowo include: First, Ganjar Pranowo presents himself as a religious leader. Second, Ganjar Pranowo presents himself as a leader close to middle to lower-class people. Third, Ganjar Pranowo presents himself as a leader who upholds ethnicity and culture. Fourth, Ganjar Pranowo displays that he is a leader who supports improving the community's economy through UMKM. Fifth, Ganjar Pranowo presents himself as a leader close to the younger generation. Ganjar Pranowo's political branding capability lies in personality attributes. The personal attributes found in the Twitter account @ganjarpranowo include: First, competence as a leader. Second, passion and dedication. Third, leadership style. This research is expected to provide an overview related to political branding from political actors and stakeholders.
Komunikasi Antarbudaya Masyarakat Pendatang Di Pulau Sebatik Perbatasan Indonesia-Malaysia
Authors:   Mulawarman University, Saleh Muhammad Hairul , Saleh Muh Harliman ,   Mulawarman University, Oktavianus Ignasius Dwi ,   Mulawarman University
Published: January 2024

This study on intercultural communication of migrant communities on Sebatik Island on the Indonesia-Malaysia border examines communication practices between Javanese, Bugis, and Timorese migrants. Using a qualitative approach and collecting data from in-depth interviews and participatory observations, the study found that the process of intercultural communication is created through economic and cultural arenas. Communication in the Javanese economic arena with the Bugis can be seen from the businesses carried out together, such as culinary, hospitality, supermarket businesses and at the same time recruiting Javanese and Bugis as employees of their businesses. In the cultural arena, intercultural communication can be seen from the phenomenon of intermarriage which allows the creation of perceptual similarities between them. Communication in the Timorese economic arena with the Bugis is seen in the vegetable business network which is the main source of income for the Timorese and the recruitment of Timorese as assistants in the Bugis household. Communication in the cultural arena between Timorese and Bugis is also seen in terms of mixed marriages as well as between Javanese and Bugis. Through the economic and cultural arena, there is a change in the mindset of some people which has implications for the creation of a more dynamic and harmonious community condition in the context of communication of border communities with various differences in culture, customs, languages, and religions.
PENGARUH PENGGUNAAN CHAT GPT SEBAGAI CONTENT CREATION DALAM MEMBANGUN PERSEPSI KONSUMEN TERHADAP STRATEGI PEMASARAN UMKM
Authors: Amalia Syifa , Karomatan Tresna , Ridwan Witsqa Inayatussholiha
Published: January 2024

This paper delves into the effects of the society 5.0 period, particularly looking at how AI technology, and Chat GPT in particular, have contributed to societal development. Rapid advancements in artificial intelligence have been made with the release of Chat GPT, the newest breakthrough from Open AI. It can solve a number of hard jobs. Nonetheless, Micro, Small, and Medium Enterprises (MSMEs) become an essential response to the severe lack of employment opportunities and the high level of artificial intelligence (AI), particularly in the context of Chat GPT in Indonesia. Technology, and more specifically Chat GPT as a content production tool, provide problems for micro, small, and medium-sized enterprises (MSMEs) when trying to reach clients online. Chat GPT offers speed and cost efficiency to MSMEs' marketing tactics, but it also raises questions about the future of human work. In light of these dynamics, the question of how society and the government might assist MSMEs in adapting to technological change must be given considerable thought. This study highlights the need of balancing technical innovation with economic sustainability, managing social effect in this age of sophisticated technology, and connecting the use of Chat GPT in content production with MSMEs marketing strategies.
Inhibition of the Progression of Chronic Kidney Disease With Hyperuricemia
Authors: Murkamilov I. , Sabirov I. , Raimzhanov Z. , Yusupova Z. , Yusupova T. , Zakirov O. , Yusupov F.
Published: January 2024

The final product of the catabolism of purine compounds in humans is uric acid (UA), which is a weak organic acid, over 98% of which is ionized into monosodium urate. UA is excreted by the kidneys, approximately 80-99% is reabsorbed in the proximal tubules of the kidneys. About 20% of UA is excreted through the intestine, where it is destroyed by microflora to carbon dioxide and water. The reference value of UA in blood plasma is 6.5-7 mg/dl in men and 6–6.5 mg/dl in women. The content of UA in the range of 360-400 μmol/l or 6-6.8 mg / dl increases the risk of crystallization under physiological conditions, and regardless of gender. UA levels greater than 7.0 mg/dl are associated with an increased risk of developing gout or nephrolithiasis. Hyperuricemia may occur due to increased production and / or decreased renal excretion of UA. Hyperuricemia is high in the general population and is associated with the development and progression of chronic kidney disease (CKD). Currently, allopurinol and febuxostat are used to correct hyperuricemia. The use of allopurinol should begin with a low dose (50-100 mg/day) and gradually titrate until the target level of UA in the blood is reached or until it is reached to the maximum. If necessary, the dose of allopurinol is increased by 100 mg every 2–4 weeks until the target serum UA level is reached. According to EULAR's recommendations for the treatment of gout, if the target level of UA cannot be achieved with an adequate dose of allopurinol, it should be replaced with febuxostat or uricosuric or a combination of febucostat with uricosuric. Febuxostat is also indicated for allopurinol intolerance. Febuxostat in doses of 80 and 120 mg/day was more effective than allopurinol at a dose of 300 mg/day. With CKD with mild or moderate renal failure, as well as in the elderly, it is not necessary to adjust the dose of febuxostat. The likelihood of reaching the target level of UA in the blood with reduced kidney function is higher in febuxostat. If the patient does not have serious cardiovascular diseases, the patient can be transferred to febuxostat, starting with a dose of 40 mg/day, and gradually titrated, especially in the case of CKD.
Analysis of Initial Design Parameters Affecting the Capacity of Shortened Tracks of the Marshalling Yard of a Freight Station
Authors: Sitnikov S. , Garifullina Yu.
Published: January 2024

The article analyzes one of the current methods of determining the necessary track development of the marshalling yard of a freight station. Special attention is paid to the issue of identifying the initial design parameters that have a significant impact on the required number of shortened marshalling tracks. The complex multivariant task of determining the capacity of track development requires specification of the solution of some issues of this aspect.
Optimizing Logistic Processes and Transport Challenges in the Dynamic Landscape of Online Commerce
Authors: Arkabaev N. , Doolotbek-kyzy G. , Amanbaev S.
Published: January 2024

The article discusses modern challenges and trends in logistics associated with dynamic online commerce. It explores the optimization of logistical processes and solutions to transport problems in the context of evolving needs in the contemporary market. The article presents key innovative approaches, such as using Internet of Things technologies, artificial intelligence, and big data analytics to enhance route management, reduce excess inventory, and ensure precise delivery to endpoints. It also highlights the importance of environmental sustainability in logistics and adaptability of logistical networks to quickly respond to changes in demand. Overall, the article presents modern logistics management strategies necessary for effective operation in the online commerce sphere. The article provides a detailed analysis of the challenges faced by logistics in the dynamic online market and offers efficient solutions for optimizing transport tasks. Principles like Just-in-Time and Lean Logistics are considered pivotal methods for reducing excess inventory and improving inventory management, contributing to a more efficient supply chain. Additionally, it covers modern approaches to last-mile logistics, including the use of drones, robots, and other innovations for delivering goods to endpoints. This revolutionizes delivery methods and enhances speed and efficiency in customer service. In conclusion, it emphasizes the importance of sustainability and environmental responsibility in logistical schemes, encouraging the use of eco-friendly transportation and packaging to reduce adverse effects on the environment. The strategies discussed in the article represent vital directions for the development of contemporary logistics, aimed at efficiency, sustainability, and adaptability in the dynamic landscape of online commerce.
Problems of Legal Regulation of Interaction Between Public and Non-public Railway Transport
Authors: Vydashenko L. , Vydashenko P.
Published: January 2024

In 2023, the main regulatory document — Federal Law no. 18-FZ “Charter of Railway Transport of the Russian Federation” will celebrate its 20th anniversary, which regulates relations between participants in the transportation process, determines the basic conditions for organizing and carrying out the transportation of goods, empty cars, and the provision of railway transport services public use and non-public use. During the period of validity of the UZhT, this basic law was amended by federal laws issued by legislative bodies related to the reform of the railway industry, but changes and amendments were not made in a timely manner to the by-laws issued by executive authorities within their competence, and to the development of basic laws, which leads to problems for all transportation participants, and this is most visible when organizing the maintenance and operation of non-public routes. In the field of legal regulation of railway transport, there is a fairly large array of regulations, which contain a contradictory nature when used in work. The article discusses problematic issues that arise from untimely legal regulation of the interaction of public and non-public railway transport, as well as the conclusion and execution of contracts for the supply and removal of cars, the operation of non-public railway tracks and their maintenance. In accordance with Art. 2 UZhT non-public railway tracks (PNP) — railway access tracks adjacent directly or through other railway access tracks to public railway tracks and intended to serve certain users with railway transport services on the terms of contracts or to perform work for their own needs.
Features of the Concept for the Development of Pension Legislation of the Kyrgyz Republic
Authors: Toktobaev B. , Kydyrgychova Z.
Published: January 2024

The article is devoted to the generally significant legislative policy of the state in the field of social security; The legal, organizational and financial foundations of the functioning of the system and the reform of pension legislation as a special area of social protection of citizens’ pension rights are considered. The purpose of the authors’ research task is to attempt to assess certain aspects of the legal policy pursued by the Kyrgyz Republic in the context of promoting structural reforms in the field of pension legislation, in particular the development of phased conceptual programs to improve well-being and maintain a decent standard of living for citizens applying for and possessing pension rights. The object of the study was social relations related to the implementation of the state’s legal policy in the field of pension legislation. The subject of the study is a set of rules regulating the legal mechanism of the activities of state and partly non-state mechanisms for the implementation of social policy in the field of pension rights. The research methods represent a dialectical method of cognition of socio-legal phenomena, formal-logical and structural-functional. The authors conclude that the measures taken in the republic in the field of optimization of pension legislation have a certain positive effect on the state of personal security, including increasing a decent standard of living, the well-being of the state, and the social and legal activity of citizens.
Harmonization of Pension Legislation of the EAEU in the Field of Social Security Rights of Workers
Authors: Aidarbekova G. , Kydyrgychova Z.
Published: January 2024

The article examines the harmonization of pension legislation as one of the most important areas of the legal policy of the EAEU member states, which is focused on jointly resolving issues of implementing equal conditions of social security rights for workers of the Union; The processes of formation of pension rights and mutual responsibility of member states when exporting pensions on the principle of proportionality and territoriality are considered using the example of the EAEU Agreement on Pension Security. The authors identified the problems of applicability of the transitional provisions of this Agreement, the participating states of the obligations associated with conflicts arising in national legislations.
The Main Aims and Social Status of Rural Women (On the Example of Regions of Uzbekistan)
Authors: Nurullaeva U.
Published: January 2024

Based on data from the study “Life goals and value orientations of rural women”, the article analyzes the sociocultural attitudes of women that determine their social well-being and mood. Against the background of consideration of social values, an analysis of the well-being of women is carried out from the point of view of their socio-demographic characteristics. The study was carried out by researchers of the Family and Women Research Institute with the support of the Women’s Committee of Uzbekistan. The main methods for collecting empirical information were interviews among respondents — women in rural areas aged from 18 to 60 years and older, expert surveys (in-depth interviewing) among specialists, as well as secondary sociological analysis of relevant data from the Mahalla and Family Research Institute and other research on the topic being studied. The sociological survey covered a total of 819 respondents. Social surveys of the main contingent of women were conducted in remote villages of the Republic of Karakalpakstan (86), Kashkadarya (148), Bukhara (88), Fergana (171), Samarkand (177) and Tashkent (130) regions. Duration of the sociological survey and analysis of the collected empirical data: from January to April 2023. The study revealed that women in rural areas are characterized by optimism, regardless of their living conditions and nominal parameters. The analyzed data made it possible to consider women in rural areas of Uzbekistan as a special socio-demographic category.
The Refugee Crisis in Europe: An Analysis of the EU’s Response and Its Impact on Member States
Authors: Gazi T.
Published: January 2024

The refugee crisis in Europe has been a pressing issue for several years now, with millions of people fleeing conflict, persecution and poverty in their home countries. The European Union (EU) has been at the forefront of efforts to address the crisis, with member states grappling with the challenge of providing a haven for refugees while also dealing with large-scale migration political, economic and social implications domestically. The article will clarify these problems.
The Role of Spouses’ Relationships in Ensuring Family Well-being
Authors: Egamberdieva N. , Yulchiyeva D.
Published: January 2024

There is an acute problem in the world of family relationships, their impact on human development, determining the dependence of social factors on the well-being of the family, and creating a socio-pedagogical mechanism aimed at increasing the level of happiness of families. One of the priority areas is to further improve the comprehensive education of children in the family, to ensure the stability of family relationships, and to expand pedagogical opportunities. Based on this, our study highlights the problems of family problems that affect the sustainability of today’s families and the implementation of mechanisms for eliminating stereotypes through pedagogical mechanisms through training seminars. The article mainly reveals the need to focus on improving the relationship of spouses’ by improving traditional and empathic mechanisms.
Sağlık Bilimleri Fakültesi Öğrencilerinde Ortoreksiya Nervoza Eğilimi ve Etkileyen Faktörler
Authors: Avcı Sezer , Çiğdem Zerrin , Güler Selver , Işıl Özlem , Ortabağ Tülay
Published: January 2024

Amaç: Bu çalışma, Sağlık Bilimleri Fakültesi öğrencilerinde ortoreksiya nervoza eğilim düzeyini ve eğilimi etkileyen faktörleri incelemek amacıyla planlanmıştır.
Gereç ve Yöntemler: Kesitsel tipteki bu araştırma, Aralık 2019-Mart 2020 tarihleri arasında Gaziantep İli’ndeki bir vakıf üniversitesi öğrencileri ile gerçekleştirildi. Araştırmanın evreni 865, örneklemi ise 594 öğrenciydi. Veriler, 31 sorudan oluşan anket formu ve ortoreksiya-11 ölçeği ile toplandı. Veriler, ki-kare, bağımsız örneklemler t testi ve tek yönlü varyans analizi ile değerlendirildi.
Bulgular: Araştırmaya katılan öğrencilerin ortoreksiya-11 puan ortalamalarının 26,56±4,40 olduğu ve %30,0’ının ortoreksiya nervoza açısından riskli olduğu tespit edildi. Öğrencilerin cinsiyet, öğrenim gördükleri bölüm ve günlük öğün sayılarına göre ortoreksiya-11 Ölçeği puan ortalamaları arasında istatistiksel olarak anlamlı bir fark bulunmadı (p>0,05). Diyet yapan, doğru beslenmeye önem veren, günlük kalori alımına dikkat eden, kilo alma endişesi yaşayan, fiziksel aktivite yapan, tüketilen yiyeceğin son kullanma tarihine ve içeriğine bakan öğrencilerin ortoreksiya eğiliminin daha fazla olduğu belirlendi (p
Is there a relationship between Diffusion Weighted Imaging and Histopathological Type in Brain Metastases Due to Breast Cancer?
Authors: KAVAK Şeyhmus , ÇİLEDAĞ Nazan
Published: January 2024

Aim: The aim of this study is to evaluate the relationship between diffusion-weighted imaging (DWI) properties and apparent diffusion coefficient (ADC) values of metastases with the histological type of breast cancer in patients with breast cancer-related brain metastasis.

Material and Methods: Between May 2008 - April 2011, 57 female patients who had been previously diagnosed with breast cancer in the radiology clinic were included in the study. Cases with invasive ductal carcinoma were considered group 1 (46 patients, 89 lesions) and cases with invasive lobular, comedo carcinoma and papillary cribriform carcinoma were considered group 2 ( 11 patients, 25 lesions). ADC values in both groups were compared by statistical analysis methods.

Results: In group 1; 37 lesions (41.57%) and in group 2; 13 lesions (52%) included cystic component. In the group of invasive ductal carcinoma 48 lesions (53.92%) and 18 lesions (72%) of second group included peritumoral edema. The mean ADC value of the solid component of metastases (group1: 1.105x10-3mm2/ s, group2: 1.099x10-3mm2/ s) was higher than the average ADC value of normal brain parenchyma (group1: 0.790x10-3mm2/s, group2: 0.801x10-3mm2/s), and was statistically significant (p
The Effect of Incarceration on Political Beliefs for Vulnerable Populations
Authors: Martinez Hope
Published: January 2024

In an era of mass incarceration and increased polarization of prison reform, I explore the interrelated question: if incarceration affects political beliefs, and, if so, for whom are these effects strongest? I use data from over 5,000 inmate responses to a survey collected from jails and prisons across the United States in 2020 by the Marshall Project. My results demonstrate that incarceration significantly affects political beliefs of currently incarcerated people and the most vulnerable demographics imprisoned — women and people of color — experiencing an increased change in political beliefs compared to men and white counterparts.
LA DEMANDA TURÍSTICA INTERNACIONAL. MEDIO SIGLO DE EVOLUCIÓN
Authors: Flores Ruiz David , Barroso González María de la O
Published: January 2024

El presente artículo analiza el comportamiento que sigue la demanda de turismo internacional desde mediados del siglo pasado hasta la actualidad, con objeto de ponerla en relación con el crecimiento que la economía mundial y el comercio internacional ha venido experimentando en este mismo período. De esta forma, se pretende contrastar la hipótesis de trabajo centrada en la ?exibilidad que experimenta este tipo de demanda, respecto a otros grandes sectores productivos, a la hora de adaptarse y recuperarse a las sucesivas crisis experimentadas por la economía mundial. En este sentido, se pone de mani?esto que la demanda de turismo internacional tiene un comportamiento procíclico, siendo estos ciclos más intensos que los propios de la economía mundial y las exportaciones de otros bienes y servicios.
Pobreza y recesión en la zona euro
Authors: Fernández Morales Antonio , García Lizana Antonio , Martín Reyes Guillermina
Published: January 2024

A menudo se compara la situación económica actual con los episodios vividos en los años treinta y setenta del pasado siglo. Sin embargo, se pasa por alto analizar detenidamente no sólo las semejanzas, sino también las diferencias, lo que podría arrojar luz sobre las patologías económicas que deben afrontarse. El análisis de la evolución de los acontecimientos en la Zona Euro permite llamar la atención sobre la existencia de problemas tanto en el lado de la oferta como de la demanda; así como sobre la eventual incidencia de las mayores tasas de riesgo de pobreza en el agravamiento de la situación, lo que convertiría las preocupaciones políticas para reducir la pobreza no sólo en un desafío desde el punto de vista de la solidaridad, sino también de la eficacia política ante los problemas de la recesión.
Epigenome-wide DNA methylation analysis of late-stage mild cognitive impairment
Authors: Zhang Yi , Shen Shasha
Published: January 2024

Background: Patients with late-stage mild cognitive impairment (LMCI) have a higher risk of progression to Alzheimer’s disease (AD) than those with early-stage mild cognitive impairment (EMCI). However, previous studies have often pooled EMCI and LMCI patients into a single MCI group, with limited independent investigation into the pathogenesis of LMCI.

Methods: In this study, we employed whole-genome methylation association analysis to determine the differences in peripheral blood methylation profiles between 663 cognitive aging (CN) and 554 LMCI patients.

Results: Our results revealed 2,333 differentially methylated probes (DMPs) and 85 differentially methylated regions (DMRs) specific to LMCI. The top hit methylation sites or regions were associated with genes such as SNED1, histone deacetylases coding gene HDACs, and HOX and ZNF gene family. The DNA methylations upregulated the expression of HDAC4, HDAC8, and HOX family genes HOXC5 and HOXC9, but they downregulated the expression of SNED1, ADCYAP1, and ZNF family genes ZNF415 and ZNF502. Gene Ontology (GO) and KEGG analysis showed that the genes associated with these methylation sites were predominantly related to the processes of addiction disorders, neurotransmission, and neurogenesis. Out of the 554 LMCI patients included in this study, 358 subjects (65%) had progressed to AD. Further association analysis between the LMCI subjects with a stable course (sLMCI) and those who progressed to AD (pLMCI) indicated that the methylation signal intensities of HDAC6, ZNF502, HOXC5, HOXC6, and HOXD8 were associated with increased susceptibility to AD. Protective effects against progression to AD were noticed when the methylation of SNED1 and ZNF727 appeared in LMCI patients.

Conclusion: Our findings highlight a substantial number of LMCI-specific methylated biomarkers that differ from those identified in previous MCI case–control studies. These biomarkers have the potential to contribute to a better understanding of the pathogenesis of LMCI.
Elucidating the binding mechanism of SARS-CoV-2 NSP6-TBK1 and structure-based designing of phytocompounds inhibitors for instigating the host immune response
Authors: Suleman Muhammad , Ishaq Iqra , Khan Haji , Ullah khan Safir , Masood Rehana , Albekairi Norah A. , Alshammari Abdulrahman , Crovella Sergio
Published: January 2024

SARS-CoV-2, also referred to as severe acute respiratory syndrome coronavirus 2, is the virus responsible for causing COVID-19, an infectious disease that emerged in Wuhan, China, in December 2019. Among its crucial functions, NSP6 plays a vital role in evading the human immune system by directly interacting with a receptor called TANK-binding kinase (TBK1), leading to the suppression of IFNβ production. Consequently, in the present study we used the structural and biophysical approaches to analyze the effect of newly emerged mutations on the binding of NSP6 and TBK1. Among the identified mutations, four (F35G, L37F, L125F, and I162T) were found to significantly destabilize the structure of NSP6. Furthermore, the molecular docking analysis highlighted that the mutant NSP6 displayed its highest binding affinity with TBK1, exhibiting docking scores of −1436.2 for the wildtype and −1723.2, −1788.6, −1510.2, and −1551.7 for the F35G, L37F, L125F, and I162T mutants, respectively. This suggests the potential for an enhanced immune system evasion capability of NSP6. Particularly, the F35G mutation exhibited the strongest binding affinity, supported by a calculated binding free energy of −172.19 kcal/mol. To disrupt the binding between NSP6 and TBK1, we conducted virtual drug screening to develop a novel inhibitor derived from natural products. From this screening, we identified the top 5 hit compounds as the most promising candidates with a docking score of −6.59 kcal/mol, −6.52 kcal/mol, −6.32 kcal/mol, −6.22 kcal/mol, and −6.21 kcal/mol. The molecular dynamic simulation of top 3 hits further verified the dynamic stability of drugs-NSP6 complexes. In conclusion, this study provides valuable insight into the higher infectivity of the SARS-CoV-2 new variants and a strong rationale for the development of novel drugs against NSP6.
Resistance against two lytic phage variants attenuates virulence and antibiotic resistance in Pseudomonas aeruginosa
Authors: García-Cruz Juan Carlos , Rebollar-Juarez Xareni , Limones-Martinez Aldo , Santos-Lopez Cristian Sadalis , Toya Shotaro , Maeda Toshinari , Ceapă Corina Diana , Blasco Lucia , Tomás María , Díaz-Velásquez Clara Estela , Vaca-Paniagua Felipe , Díaz-Guerrero Miguel , Cazares Daniel , Cazares Adrián , Hernández-Durán Melisa , López-Jácome Luis Esaú , Franco-Cendejas Rafael , Husain Fohad Mabood , Khan Altaf , Arshad Mohammed , Morales-Espinosa Rosario , Fernández-Presas Ana María , Cadet Frederic , Wood Thomas K. , García-Contreras Rodolfo
Published: January 2024

Background

Bacteriophage therapy is becoming part of mainstream Western medicine since antibiotics of clinical use tend to fail. It involves applying lytic bacteriophages that self-replicate and induce cell lysis, thus killing their hosts. Nevertheless, bacterial killing promotes the selection of resistant clones which sometimes may exhibit a decrease in bacterial virulence or antibiotic resistance.

Methods

In this work, we studied the Pseudomonas aeruginosa lytic phage φDCL-PA6 and its variant φDCL-PA6α. Additionally, we characterized and evaluated the production of virulence factors and the virulence in a Galleria mellonella model of resistant mutants against each phage for PA14 and two clinical strains.

Results

Phage φDCL-PA6α differs from the original by only two amino acids: one in the baseplate wedge subunit and another in the tail fiber protein. According to genomic data and cross-resistance experiments, these changes may promote the change of the phage receptor from the O-antigen to the core lipopolysaccharide. Interestingly, the host range of the two phages differs as determined against the Pseudomonas aeruginosa reference strains PA14 and PAO1 and against nine multidrug-resistant isolates from ventilator associated pneumonia.

Conclusions

We show as well that phage resistance impacts virulence factor production. Specifically, phage resistance led to decreased biofilm formation, swarming, and type III secretion; therefore, the virulence towards Galleria mellonella was dramatically attenuated. Furthermore, antibiotic resistance decreased for one clinical strain. Our study highlights important potential advantages of phage therapy’s evolutionary impact that may be exploited to generate robust therapy schemes.