bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel allatostatin-A analog, III-2 may particularly regulates juvenile hormone III to influence Spodoptera frugiperda metamorphosis and development
Authors: Cao Wenjing , Zhang Fu , Li Haolin , Zhang Yimeng , Zhang Yongheng , Zhang Wenjie , Guo Xiaxia , Dong Linxi , Li Honghong , Zeng Dongqiang , Li Xuesheng , Yang Xinling
Published: July 2023

Allatostatin (AST) is a class of insect neuropeptides that affects insect growth and development by inhibiting the synthesis of juvenile hormones (JH) in different insects. Ⅲ-2 is a novel allatostatin-A（AST-A）analog derived from a class of nitroaromatic groups connected by different amino acids. In this study, we found that Ⅲ-2 showed high insecticidal activity against S. frugiperda larvae with a LC50 of 18.7 mg L-1. As demonstrated by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), III-2 particularly encouraged JH III and hindered 20E synthesis in S. frugiperda. The results of RNA-Seq and quantitative real-time polymerase chain reaction (qPCR) showed that Ⅲ-2 treatment promoted the expression of JH terminal synthetases SfCYP15C1 and SfJHAMT and inhibited the expression of SfJHE and SfJHEH in the metabolic pathway of JH. Significant differences were observed in the expression of the genes related to cuticle formation. We report for the first time that AST compounds specifically interfere with the synthesis and secretion of a certain JH in insects, thus affecting the ecdysis and growth of insects, and leading to death. This study may provide a new plant conservation concept for us to seek the targeted control of certain insects based on specific interference with different JH.
Altered Piwi-RNA Profiles of Peripheral Blood in Bone Metastasis of Non-Small Cell Lung Cancer
Authors: Fan Wen-bin , Li Min , Miao Haoran , Li Kai-bo , Ding Feng , Zhang Yi-qian , Jin Song , Cheng Wenxiang
Published: July 2023

Background
PIWI-interacting RNAs (piRNA) are a novel class of non-coding RNAs. They are involved in various pathophysiological activities. However, the expression profiles and functions of piRNAs in the bone metastasis of non-small cell lung cancer are still largely unknown.
Methods
Blood samples were collected from patients with non-small cell lung cancer (NSCLC), NSCLC with bone metastasis (BoM) and from healthy volunteers. To evaluate piRNA expression profiles in these samples, high-throughput piRNA microarray was performed. RStudio was used for PCA analysis. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate significantly dysregulated piRNAs. To predict the potential functions of dysregulated piRNAs, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. The mRNA targets of the piRNAs were predicted using TargetScan and miRanda software. The interaction networks between the piRNAs and their targets were constructed using Cytoscape software.
Results
A total of 11026 differentially expressed piRNAs were identified, including 134 up-regulated piRNAs and 45 down-regulated piRNAs in NSCLC with bone metastasis (LCBM) vs. non-small cell lung cancer (LC) group and 760 up-regulated piRNAs and 975 down-regulated piRNAs in LCBM vs. healthy volunteers (Ctrl) group with P ≤0.05, fold change ≥1.0. Twenty-four dysregulated piRNA genes with statistically significant differences among all three groups were selected to be validated by qPCR. The qRT-PCR validation confirmed the reliability of the microarray data. The potential targets were predicted by combining with the miRanda and TargetScan software analyses. Through GO and KEGG analysis, these dysregulated piRNAs were found to be potentially involved in NSCLC with BoM pathogenesis. In particular, these pi-RNA might be involved in the transcriptional misregulation and osteoclast differentiation in lung cancer and the bone metastasis.
Conclusions
In conclusion, we have identified novel piRNAs that play important functional roles in initiating and progressing of NSCLC with BoM. Bioinformatics analyses suggested that these dysregulated piRNAs may play an important functional role in the tumorigenesis of NSCLC, especially in the BoM. We identified that piR-hsa-16644 is a potential biomarkers and therapeutic target for BoM, and piR-hsa-11510 is strongly associated with EGFR tyrosine kinase inhibitor resistance.
Altered plasma metabolites and inflammatory networks in HIV-1 infected patients with different immunological responses after long-term antiretroviral therapy
Authors: Lu Lianfeng , Yang Yang , Yang zhangong , Wu Yuanni , Liu Xiaosheng , Li Xiaodi , Chen Ling , Han Yang , Song Xiaojing , kong Ziqing , Cao Wei , Li Taisheng
Published: July 2023

Background: Chronic metabolic changes relevant to human immunodeficiency virus type 1 (HIV-1) infection and in response to antiretroviral therapy (ART) remain undetermined. Moreover, links between metabolic dysfunction caused by HIV and immunological inflammation in long-term treated individuals have been poorly studied.
Methods: Untargeted metabolomics and inflammatory cytokine levels were assessed in 50 HIV-infected individuals including 25 immunological responders (IRs) and 25 non-responders (INRs) before and after ART. The IRs and INRs were matched by age, gender, baseline viral load and baseline CD4+T cell counts. Another 25 age-matched uninfected healthy individuals were also included as controls.
Results: Among the 770 plasma compounds detected in the current study, significant changes were identified in lipids, nucleotides, and biogenic amino acids between HIV-infected patients and healthy controls. Principal Component Analysis (PCA) and Random Forest (RF) model suggested that levels of selected metabolites could differentiate HIV infected patients clearly from healthy controls. However, only three metabolites including maltotetraose, N,N-dimethyl-5-aminovalerate and decadienedioic acid (C10:2-DC) were different between IRs and INRs following long-term ART. The pathway enrichment analysis results revealed that disturbances in pyrimidine metabolism、sphingolipid metabolism and purine metabolism after HIV infection and these changes did not recover to normal levels in healthy controls even with suppressive ART. Correlation analysis of the metabolism-immune network indicated that interleukin (IL)-10, D-dimer, vascular cell adhesion molecule-1(VCAM-1), intercellular cell adhesion molecule-1(ICAM-1) and TNF-RII were positively correlated with most of the significantly changed lipid and amino acid metabolites, but negatively correlated with metabolites in nucleotide metabolism.
Conclusions: Significant changes of many metabolites were observed in HIV-infected individuals before and after ART, regardless of their immunological recovery status. The disturbed metabolic profiles of lipids and nucleotides in HIV infection did not recover to the normal levels even after long-term ART. These changes are correlated with modified cytokines and biomarkers of chronic non-AIDS events, warranting try out of interventions other than ART.
Transthyretin amyloid cardiomyopathy in patients with unexplained increased left ventricular wall thickness.
Authors: Holcman Katarzyna , Kostkiewicz Magdalena , Szot Wojciech , Ćmiel Bogdan , Mróz Krystian , Stępień Agnieszka , Graczyk Katarzyna , Dziewięcka Ewa , Karabinowska-Małocha Aleksandra , Sachajko Zuzanna , Podolec Piotr , Rubiś Paweł
Published: July 2023

Purpose
Amyloid cardiomyopathy (CA) was previously considered a rare disease; however, rapid advancements in imaging modalities have led to an increased frequency of its diagnosis. The aim of this prospective study was to assess the prevalence and clinical phenotype of transthyretin amyloidosis (ATTR) cardiomyopathy in patients exhibiting unexplained increased left ventricular (LV) wall thickness.
Methods
From 2020 to 2022, we enrolled 100 consecutive adults with unexplained increased LV wall thickness in the study. The analysis included clinical data, electrocardiography, transthoracic echocardiography, single-photon emission computed tomography/computed tomography (SPECT/CT) with 3,3-disphono-1,2-propanodicarboxylic acid (DPD), genetic testing.
Results
Overall, 18% of patients were diagnosed with CA, comprising 5% with light-chain amyloidosis, and 12% with ATTR. To evaluate associations with the ATTR diagnosis, a LOGIT model and multivariate analysis were applied. Notably, age, polyneuropathy, gastropathy, carpal tunnel syndrome, lumbar spine stenosis, low voltage, ventricular arrhythmia, LV mass, LV ejection fraction, global longitudinal strain (GLS), E/A, E/E’, right ventricle (RV) thickness, right atrium area, RV VTI, TAPSE, apical sparing, ground glass appearance of myocardium, thickening of interatrial septum, thickening of valves, and the ''5-5-5'' sign were found to be significantly associated with ATTR (p < 0.05). The best predictive model for ATTR diagnoses exhibited an area under the curve (AUC) of 0.99, including LV mass, GLS and RV thickness.
Conclusion
This study, conducted at a cardiology referral center, revealed that a very considerable proportion of patients with unexplained increased LV wall thickness may suffer from underlying CA. Moreover, the presence of ATTR should be considered in patients with increased LV mass accompanied by reduced GLS and RV thickening.
Methane conversion to syngas by chemical looping on La0.8Sr0.2FexCo1-xO3 (x=0, 0.25, 0.50, 0.75) perovskites with CO2 co-feeding
Authors: S Gal , Cohen Oranit , Dahan Hen Ohayon , Landau Miron V. , Herskowitz Moti
Published: July 2023

Partial oxidation of methane (POM) by chemical looping with CO2 co-feeding on La0.8Sr0.2FeO3 (LSF) perovskite catalyst yielded a highly selective operation and enabled to extend the duration of reduction cycle. In this work, the conversion of methane to syngas was studied on La0.8Sr0.2Fe(x)Co(1−x)O3 (x = 0, 0.25, 0.5, 0.75) perovskites in chemical-looping mode, co-feeding CO2 and methane. The reaction was conducted at 850°C, 15 min reduction (10% methane in N2, 0–3% CO2), and 10 min oxidation (10% O2 in N2) cycles. The perovskites activity decreased with increasing Co content, in the absence of CO2, due to intensified coke deposition on the catalyst. Addition of CO2 during the reduction step (1%-3%) reduced coke accumulation. A run conducted on La0.8Sr0.2CoO3 (LSC) with continuous feeding of CO2 and periodical (on-off) methane feeding indicated that CO2 reacts with the accumulated coke in reverse-Boudouard reaction, increasing CO selectivity without affecting the methane conversion. XRD analysis of reduced Co-containing perovskites indicates a decreasing perovskite content. Metallic Co and La2O3 phases increased as the Co content in the fresh perovskite increased, increasing coke deposition. As the Co content increased, the process shifts from POM with oxygen replenishment (LSF) to cracking followed by reverse-Boudouard reaction (LSC).
Quantifying the Effects of Viral Load on Multistate COVID-19 Infection and Progression of Alpha and Omicron VOCs: A Bayesian Competing Markov Exponential Regression Model
Authors: Yeh Yen-Po , Yen Amy Ming-Fang , Lin Ting-Yu , Hsu Chen-Yang , Chen Sam Li-Sheng , Chen Hsiu-Hsi
Published: July 2023

We used a Bayesian competing four-state Markov model to explore how viral shedding in terms of cycle threshold (Ct) value makes relative contribution between persistent and non-persistent asymptomatic mode, and whether it affects the subsequent progression to show symptoms. The proposed model was applied to data from two large outbreaks on Alpha and Omicron variants of concern (VOCs) in Changhua, Taiwan. A multistate Markov exponential regression model was proposed for quantifying the odds ratio (OR) of viral shedding measured by cycle threshold (Ct). A Bayesian Markov Chain Monte Carlo (MCMC) method was used for estimating the parameters of the posterior distribution. The estimated results show that developing non-persistent asymptomatic mode relative to persistent asymptomatic mode was reduced by 14% (adjusted OR = 0.86, 95% CI: 0.81–0.92) per one increasing unit of Ct for Alpha VOC, whereas these figures were shrunk to 5% (aOR = 0.95, 95% CI: 0.93–0.98) for Omicron VOC. Similar significant gradient relationships were also observed between three viral load levels. Similar, but not statistically significant, dose-response effects of viral load on the progression to symptoms for non-persistent asymptomatic mode were observed. The application of statistical model helps elucidate the pathways of SARS-CoV-2 infectious process associated with viral shedding that demonstrate viral shedding plays a crucial role in determining the path of either non-persistent or persistent asymptomatic mode in a dose-response manner, which was more pronounced for the Alpha than the Omicron. Modelling such a multistate infectious process with two competing pathways would provide a new insight into the transmissibility and the duration of insidious infection before onset of symptom and the deployment of precision containment measures with a better use of the Ct value as virologic surveillance for projecting the individual epidemic course.
Optimal Duration and Timing of Basic-life-support-Only Intervention for Patients with Out-of-Hospital Cardiac Arrest: A Nationwide Observational Study in Japan
Authors: Takei Yutaka , Toyama Gen , Takahashi Tsukasa , Omatsu Kentaro
Published: July 2023

Aim: The study aimed to elucidate the relationship between the interval from cardiopulmonary resuscitation (CPR) initiation to return of spontaneous circulation (ROSC) and neurologically favourable 1-month survival in order to determine the appropriate duration of basic life support (BLS) without advanced interventions.
Methods: This retrospective, population-based cohort study included patients aged ≥ 18 years with 9,132 out-of-hospital cardiac arrest (OHCA) of presumed cardiac origin who were bystander-witnessed and had achieved ROSC between 2018 and 2020 in Japan. Patients were classified into two groups based on the resuscitation methods as the “BLS-only group” and the “BLS with administered adrenaline (BLS-AA) group”.
Results: Receiver operating characteristic (ROC) curve analysis indicated that administering BLS for 9 min yielded the best neurologically outcome for patients with a shockable initial rhythm [sensitivity, 0.42; specificity, 0.27; area under the ROC curve (AUC), 0.60] in the BLS-only group. Contrastingly, for patients with a non-shockable initial rhythm, performing BLS for 6 min yielded the best neurologically outcome (sensitivity, 0.65; specificity, 0.43; AUC, 0.63). Among patients who received adrenaline, administering BLS for 15 min yielded the best neurologically outcome for patients with shockable (sensitivity, 0.52; specificity, 0.30; AUC, 0.64) and non-shockable (sensitivity, 0.61; specificity, 0.31; AUC, 0.68) rhythms. Based on the ROC curve analysis results, we defined early ROSC achievement as within 9 min and 6 min for patients with shockable and non-shockable rhythms, respectively. Multivariate analysis indicated that BLS-only resuscitation had the most significant impact on early ROSC achievement in patients with shockable [odds ratio; 95% confidence interval): 9.98 (8.25–12.07) and non-shockable [28.97 (23.10–36.34)] rhythms. After propensity score matching, multivariate analysis revealed that neurologically favourable 1-month survival was associated with BLS-only resuscitation [5.00 (4.08–6.13)], night-time events [1.29 (1.03–1.62)], patient age [0.95 (0.94–0.96)], male sex [1.45 (1.16–1.81)], bystander CPR [1.55 (1.28–1.87)], initial shockable rhythms [3.21 (2.64–3.91)], transportation to level-3 hospitals [1.65 (1.37–1.98)], CPR-to-ROSC interval [0.96 (0.95–0.98)], and on-scene time [0.97 (0.95–0.99)].
Conclusion: Our findings suggest that paramedics should provide concentrated and high-quality chest compressions within the first few minutes of scene arrival prior to administering advanced interventions.
Clinical characteristics and pathologic complete response (pCR) rate after neoadjuvant chemotherapy in postpartum women with breast cancer
Authors: Dou He , Jia Si , Ba Yu , Luo Dan , Yu Ping , Li Fu cheng , Wang You , Chen Xing , Xiao Min
Published: July 2023

Purpose
Breast cancer (BC) is currently the leading cause of death in women worldwide. Studies have confirmed that pregnancy is an independent factor affecting the survival of BC patients. BC found during pregnancy, lactation, or shortly after delivery is what we used to think of as pregnancy-associated breast cancer (PABC). The current expert definition of this concept is not uniform; however, there is growing evidence that postpartum breast cancer (PPBC) differs from other types of BC in terms of both biological features and prognosis, with a slightly different focus on diagnosis and treatment. With the increase of female reproductive age population and changes in fertility policies in China, patients with PPBC are receiving increasing attention. Here, we systematically analyzed the clinicopathological characteristics and chemotherapeutic response of patients with PPBC.
Patients and methods
We retrospectively analyzed the clinicopathological data, molecular subtypes, chemotherapy regimens and pathological complete remission (pCR) rates of 1343 patients with non-metastatic BC at Harbin Medical University Cancer Hospital from January 1, 2012 to May 31, 2023. The categorical data were compared by chi-square test and Fister exact test using logistic regression model. Predictor variables with P < 0.05 in the univariate analysis were included in the multivariate regression analysis to investigate the relationship between different age groups and pCR.
Results
A total of 714 patients were eligible for analysis in this study, and 667 patients had a history of pregnancy, 40 (5.6%) of whom were PPBC patients.
When diagnosed with BC, patients with PPBC were younger, more likely to undergo breast-conserving surgery (BCS), and more likely to achieve pCR (P < 0.05). In molecular typing, human epidermal growth factor receptor 2 (HER-2)-positive and triple-negative breast cancer (TNBC) were more frequent. In the entire cohort, HER-2 expression and delivery status were independent predictors of pCR rates in BC patients after neoadjuvant chemotherapy (NAC).
Conclusion
Our findings suggest that postpartum status is an independent predictor of pCR attainment in BC patients. PPBC is more sensitive to chemotherapy than other patients,We need to pay more attention to this group and achieve individualized treatment, which will help us treat BC better and provide new targets and blueprints for our clinical therapy.
Tuning Photocatalytic Efficiency through Cu Doping in Ni-Zn Ferrite Nanoparticles: Structural and Optical Characteristics
Authors: Bhamare Jyoti D. , Pandit Vishal A. , Chaudhari N.D.
Published: July 2023

In this study, Undoped and Cu-doped Ni0.6-x Zn0.4CuxFe2O4 (x = 0, 0.3) ferrite nanoparticles were synthesized using the sol-gel auto combustion method. The nanoparticles exhibited a single-phase spinel crystal structure as confirmed by XRD analysis. The crystallite sizes were determined to be in the range of 20 to 30 nm. SEM revealed the nanoparticles to have a spherical morphology. EDS confirmed the elemental composition and purity of the nanoparticles. FTIR analysis provided insights into the vibrational modes and bonding characteristics of the nanoparticles. UV-VIS was employed to investigate the optical properties of the nanoparticles, revealing band gap energies ranging from 2.80 to 3.5 eV. The photocatalytic activity of the nanoparticles was evaluated through the degradation of methylene blue under sunlight irradiation, demonstrating their effectiveness as photocatalysts. These findings contribute structural and optical properties of undoped and Cu-doped Ni-Zn ferrite nanoparticles, emphasizing their potential as efficient photocatalysts for environmental applications.
Causal impact of genetically-determined fish and fish oil intake on epigenetic age acceleration and related serum markers
Authors: Fabian Paul , Blander Gil , Deehan Renee , Torkamani Ali , Nogal Bartek
Published: July 2023

Background: The interplay between diet and healthspan is a topic of great interest in biomedical research. Toward this end, consumption of marine omega-3 fatty acids is of particular significance, as reports suggest that diets focused on seafood can prolong the disease-free portion of the human lifespan. Fish consumption has also been linked to reduced biological aging as measured by epigenetic clocks, but there is no conclusive evidence of a causal relationship. Moreover, fish oils reduce triglycerides, and may affect other lipid profiles, as well as systemic inflammation. To investigate further, we used two-sample Mendelian randomization to infer causality between fish intake and healthspan markers.
Methods: We perform bidirectional Mendelian randomization in the two-sample setting using publicly available GWAS summary statistics repositories. Usingoily fish consumption and fish oil supplementation as the primary exposures, we attempt to elucidate the causal landscape of these interventions on first- and second-generation epigenetic clocks as well as serum proxies of lipidemia and systemic inflammation.
Results: We report that oily fish consumption appears to causally modify PhenoAge (p < 0.0074), whereas it begins to approach causality with respect to GrimAge (p = 0.097). However, fish oil supplements do exhibit a causal relationship with GrimAge (p = 0.037). Both omega-3 exposures modify the epigenetic clocks in the expected negative, or age-decelerating, direction. We also confirm the causal relationship between fish oil consumption and triglyceride reduction (p = 0.004), though HDL and LDL were not significantly modified. Finally, we also detect suggestive causality between oily fish consumption and reduced hsCRP (p = 0.062).
Conclusions: Our analysis shows that consuming fish oil, whether through whole food or as a supplement, can have a rejuvenating impact as measured by PhenoAge and GrimAge acceleration. We have also confirmed the causal link between fish oil intake and lower triglyceride levels. These results, based on robust MR-based analyses, emphasize the effectiveness of dietary choices in influencing healthspan.
Effect of Hesperidin on blood pressure and lipid profile: A systematic review and meta-analysis of randomized controlled trials
Authors: Shylaja Hanumanthappa , Viswanatha Gollapalle L , Venkategowda Sunil , Hussain Shalam M. , Farhana Syeda Ayesha
Published: July 2023

Background
The cardioprotective activity of hesperidin has been well demonstrated in several clinical studies. Also, there is a meta-analysis published on this topic in 2019. However, considering the recently published clinical studies there is a scope for performing a systematic review and meta-analysis on the cardioprotective effect of hesperidin. This systematic review and meta-analysis were performed to determine the beneficial effect of hesperidin in alleviating alterations in cardiovascular parameters based on available clinical studies.
Methods
The literature search was performed using online databases such as PubMed and Google Scholar. The search was mainly focused on the role of hesperidin in various cardiovascular disorders.
Results
Based on the inclusion and exclusion criteria 9 clinical studies involving 2414 subjects were included. The meta-analysis revealed that the hesperidin has significantly reduced the systolic blood pressure (Inverse variance (I.V): -0.86 (-1.53 to -0.18) at 95% CI, p = 0.01, I2 = 100%) and total triglycerides (IV: -0.21 (-0.40 to -0.02) at 95% CI, p = 0.03, I2 = 12%). However, there were no statistically significant changes in the diastolic blood pressure (IV: 0.52 (-1.78 to 2.83) at 95% CI, p = 0.06, I2 = 100%), HDL (IV: 0.04 (-0.25 to 0.34) at 95% CI, p = 0.78, I2 = 56%), LDL (IV: -0.10 (-0.66 to 0.45) at 95% CI, p = 0.72, I2 = 85%), and total cholesterol (TC) (IV: 0.18 (-0.79 to 0.44) at 95% CI, p = 0.57, I2 = 88%) compared with the placebo/control.
Conclusion
The outcomes of the meta-analysis suggest that hesperidin administration could benefit patients with cardiovascular diseases by reducing systolic blood pressure and total triglycerides.
A Real-time and High-Performance MobileNet Accelerator based on adaptive dataflow scheduling for Image Classification
Authors: Sang Xiaoting , Ruan Tao , Li Chunlei , Li Huanyu , Yang Ruimin , Liu Zhoufeng
Published: July 2023

Convolutional neural network (CNN) models equipped with depth separable convolution (DSC) promise a lower spatial complexity while retaining high model accuracy. However, little attention has been paid to their hardware architecture. Previous studies on DSC-based CNN accelerators typically use fixed computational models for various models, leading to an imbalance between power, efficiency, and performance. To address this problem, a novel, real-time DSC-based CNN accelerator that can accommodate field-programmable gate arrays (FPGAs) of different capacities and CNNs of different sizes is proposed in this paper. Attractively, a dynamically reconfigurable computing engine and block-convolution-based adaptive dataflow scheduling mode strike a trade-off between hardware resources and the processing speed in industrial processes. The proposed MobileNet accelerator was implemented and evaluated on the Xilinx XC7020 platform. Compared to previous FPGA-based accelerators, the experimental results showed that our approach can provide a frame rate of 29.4 FPS for full HD RGB images, meeting the needs of real industrial real-time applications.
Reactive Handover Coordination System with Regenerative Blockchain Principles for Swarm Unmanned Aerial Vehicles
Authors: Rajasoundaran S. , Kumar S. V.N. Santhosh , M Selvi , Kannan Arputharaj
Published: July 2023

Aerial warfare systems in various countries highly expect Swarm Unmanned Aerial Vehicles (UAVs) and Flying Adhoc Networks (FANETs) for defense stability. However, swarm UAVs face many challenges, like security breaches, malfunctions, link failures, and handover failures. UAVs can easily malfunction by external threats to create data loss, theft, signal jamming, misrouting, false handover, and location spoofing. Failures in UAV handover principles make overall gradual downtime in FANET. Against these issues, existing UAV protection mechanisms deliver location monitoring mechanisms (graphs and trees), multi-link handover mechanisms, and distributed authentication principles. Anyhow, the implantation of recent-day techniques may fail against migrating attacker events executed in electronic warfare systems. The methods need improvements in protecting Multi-UAV layers through end-to-end security principles. On the research problem, the proposed Reactive Handover Coordination System with Regenerative Blockchain Principles (RHCRB) takes novel high-security features specially made for swarm UAVs. RHCRB implements more crucial distributed functions in each UAV on demand. The executed operations of RHCRB comprise trusted location monitoring schemes (internal and cooperative UAV movements), dynamic location-based cost magnitude calculations, regenerative blockchain principles (authentication of each UAV and active edges), confidential link management principles, secure handover coordination, and on-demand topology management principles. The technical aspects of RHCRB build lightweight and shielded handover principles against airfield vulnerabilities. The proposed model suggests implementing an entirely protected handover environment from node localization to handover events. The inspired technical aspects of RHCRB contribute to the swarm UAV environment through confidential (Advanced Encryption Standard (AES)) and distributed authentication (blockchain-based node and edge management) principles to engage protected handover practices. The experimental section of this article has the testbed in FlyNetSim tool for implementing RHCRB and notable recent security techniques such as the Internet of Vehicles with Decentralized Blockchains (IoV-DB), Group Handover for Internet of Defense (GH-IoD), and Handover and Optimized Security Principles for UAVs (HOOPOE). The results show RHCRB's 8–14% of betterment than existing techniques through various measures.
Study on the Mechanism of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen in Sedation and tranquilizing mind
Authors: Zhu Chenghao , Zhang Zhengru , Sun Zhirong
Published: July 2023

Method
The chemical constituents and therapeutic targets of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen were acquired from TCMSP, HERB, and ETCM databases. Active components were identified using ADME criteria, while the primary targets associated with sedation and mental tranquility were obtained from GENECARDS, OMIM, and DRUGBANK databases. To investigate potential functional protein modules within the network, a protein-protein interaction (PPI) network analysis was conducted using the STRING platform. The METASCAPE platform was employed for the analysis of the "component-target" and its associated biological processes and pathways. Subsequently, the construction of the "component-target" network was accomplished using Cytoscape 3.9.1 software. Finally, the validation of molecular docking was conducted through AUTODOCK. Results: The findings revealed that Quercetin, Atropine, dauricine, (S)-Coclaurine, and other active ingredients were identified as the core constituents of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen. Additionally, PTGS2, PTGS1, MAOB, GABRA1, SLC6A2, ADRB2, CHRM1, HTR2A, and other targets were identified as the core targets. The results of the molecular docking analysis demonstrated that Quercetin, dauricine, and (S)-Coclaurine exhibited strong binding affinity towards PTGS2. The predominant biological pathways associated with sedation and tranquilization primarily involved neuroactive ligand-receptor interaction and activation of receptors involved in chemical carcinogenesis. This study provides initial findings on the multi-component, multi-target, and multi-pathway mechanism underlying the sedative and tranquilizing effects of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen. These findings have the potential to serve as a foundation for the future development and utilization of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen.
Early outcome of simplified total arch reconstruction under mild hypothermia (30-32°C) with distal aortic perfusion
Authors: Zheng# Hua-Jie , Liu# Xin , He Ping , Li Jun , Zhang Xian-Pu , Cheng Yong-Bo , Lin De-Qing , Yan Chao-Jun , Yu San-Jiu , Cheng Wei
Published: July 2023

Objective
We designed a simplified total arch reconstruction (s-TAR) technique which could be performed under mild hypothermia (30–32°C) with distal aortic perfusion. This study aimed to compare its efficacy of organ protection with the conventional total arch reconstruction (c-TAR).
Methods
We reviewed the clinical data of 195 patients who had ascending aortic aneurysm with extended aortic arch dilation and underwent simultaneous ascending aorta replacement and TAR procedure between January 2018 and December 2022 in our center. 105 received c-TAR under moderate hypothermia (25–28°C) with circulatory arrest (c-TAR group); rest 90 received s-TAR under mild hypothermia (30–32°C) with distal aortic perfusion (s-TAR group).
Results
The s-TAR group demonstrated shorter CPB time, cross-clamp time and lower body circulatory arrest time compared with the c-TAR group. The 30-day mortality was 2.9% for the c-TAR group and 1.1% for the s-TAR group (P = 0.043). The mean duration of mechanical ventilation was shorter in the s-TAR group. Paraplegia was observed in 4 of 105 patients (3.8%) in the c-TAR group, while no such events were observed in the s-TAR group. The incidence of temporary neurologic dysfunction was significantly higher in the c-TAR group. The incidence of permanent neurologic dysfunction also showed a tendency to be higher in the c-TAR group, without statistical significance. Furthermore, the incidence of reoperation for bleeding were significantly lower in the s-TAR group. The rate of postoperative hepatic dysfunction and all grades of AKI was remarkably lower in the s-TAR group. The 3-year survival rate was 95.6% in the s-TAR group and 91.4% in the c-TAR group.
Conclusions
s-TAR under mild hypothermia (30–32℃) with distal aortic perfusion is associated with lower mortality and morbidity, offering better neurological and visceral organ protection compared with c-TAR.
Developing approaches for search and analysis of CRISPR-Cas systems on the example of Klebsiella pneumoniae strains as a basis for creating personalized bacteriophage therapy
Authors: Stepanenko L. A. , Sukhov B. G. , Bedinskaya V. V. , Borisenko A. Yu. , Kon’kova T. V.
Published: July 2023

This paper proposes an algorithm for searching and analyzing the structures of CRISPR-Cas systems of bacteria and screening bacteriophages through spacers in CRISPR cassettes using bioinformatic research methods in the genomes of Klebsiella pneumoniae strains. The aim was to determine and study the structure of CRISPR-Cas systems of bacteria on the example of Klebsiella pneumoniae strains using bioinformatic research methods in order to develop approaches for the selection of target bacteriophages. The research object included 150 genome-wide sequences downloaded from the GenBank database. Of these sequences, CRISPR-Cas systems were detected in 52 strains, which amounted to 34.7%. Using several search algorithms in the CRISPR-Cas systems of the studied strains, the presence of one and two CRISPR cassette was determined in 46.2 and 53.8% of cases, respectively. In all the cases, a complete set of Cas genes characteristic of Type-I Subtype-I-E systems was identified next to the cassettes. The total number of the identified spacers was 1659, of which 281 spacers were repeated in two or more CRISPR loci, while 505 spacers had no repeats. The number of spacers in the cassettes ranged from 4 to 64. The analysis of the spacer composition in CRISPR cassettes of antibiotic-resistant and hospital strains provided information on their evolutionary history and on the bacteriophages which are targeted by their CRISPR systems. The developed bioinformatic analysis algorithm enables creating a platform for the development of personalized bacteriophage therapy technologies.
Prenatal gender selection: medical, ethical and psychological aspects
Authors: Kovalyova Olga , Mykytenko Dmytro
Published: July 2023

The article is devoted to the methodology of prenatal gender selection and ethical aspects of its implementation. Based on the analysis of scientific publications, the principal techniques to determine sex in pre-implantation period, in the embryo and fetus, are presented. Invasive and non-invasive procedures of prenatal diagnosis are descreibed. Invasive procedures include examination of the fetus by chorionic villus sampling karyotyping of cells obtained by amniocentesis. Non-invasive techniques related to pregnant women's blood biochemistry, ultrasound markers of the Down syndrome are given. Fetal blood DNA testing is a more sensitive diagnostic parameter that reduces the indication for invasive procedures. The newest most effective method of sex determination in pre-implantation period is sperm separation screening. Medical and non-medical reasons for prenatal gender determination such as prevention of X-linked genetic disorders in a child, a couple’s choice in order to balance sex of children in the family, social gender preferences are shown. Gender selection for the prevention of the X-linked disorders is justified. Ethical issues regarding to the balance of children in the family, giving preference to a certain sex with the help of advanced diagnostic techniques, and selective abortion are discussed. The bioethical principles for the prevention selective abortion resulted from the gender reasons are established. International documents – the Convention for the Protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine, the Declaration of the World Medical Association regulating protection against sexual discrimination are considered
Structural and mechanical properties of Turkish delight production using fruit and vegetable paste
Authors: Babaiev Serhii , Kasabova Kateryna , Samokhvalova Olga , Shydakova-Kameniuka Olena , Zagorulko Aleksey , Zahorulko Andrii , Budnyk Nina , Shkliaiev Oleksii
Published: July 2023

The purpose of the study is to determine the structural and mechanical properties of Turkish delight based on the fruit and vegetable paste made from pumpkin, quince and apples, made according to the developed technology. The developed method of production of Turkish delight with fruit and vegetable paste allows to achieve a double effect of the introduction of technology, namely to increase the content of functional ingredients in Turkish delight, as well as to achieve a technological one. Which consists in improved structural and mechanical properties of the locum mass and the finished product, and also allows to achieve original sensory characteristics without the use of dyes and flavorings. The significant content of pectin substances (4.31 % per 100 g) in the fruit and vegetable paste made it possible to achieve a reduction in the recipe content of starch in the technology of Turkish delight. This was confirmed by determining the structural and mechanical properties of the mass and the finished product. Thus, the rational content of starch is set at the level of 80 % of its prescription amount. According to the nature of the curves of the dependence of viscosity on the shear rate and the presence of the ultimate shear stress, locum mass belongs to non-ideally plastic solids. The viscosity index of the locum mass sample with paste and reduced starch content by 20 % has a value similar to the control. Also positive is the shortening of the process of cooking the locum mass in a vacuum-evaporator by 15...20 minutes due to its higher initial dry matter content compared to the control sample. The determination by an expert group of scientists of the indicators of quality in terms of structure and appearance according to a five-point rating showed that the obtained Turkish delight with paste has better indicators. The developed Turkish delight technology can be recommended for healthy nutrition
TÜRKİYE’DE ANLAŞMALI BOŞANARAK AYLIK ALANLARIN DAVRANIŞ KALIPLARI ÜZERİNE VERİ MADENCİLİĞİ UYGULAMASI
Authors: YAŞASINOĞLU Nihal , YAŞASINOĞLU Hamza , EBEGİL Meral
Published: July 2023

Son yıllarda internet ve bilişim teknolojilerinin gelişmesiyle beraber özel şirketlerin ve Kamu kurumlarının veri tabanlarında tutulan verilerin sayısı muazzam oranda artmaktadır. Bununla beraber, karar alıcılar hedefledikleri kitleye daha iyi hizmet sunabilmek ya da yönettikleri şirketlerin karlılığını artırabilmek için veri tabanlarında tutulan verilerden daha detaylı ve kapsamlı bilgiler talep etmektedir. Günümüzde bu ihtiyacı gidermek için veri madenciliği teknikleri kullanılmaktadır. Veri madenciliği farklı araştırma konularında kullanılmak üzere pek çok farklı algoritma içermektedir. Bu algoritmaları kullanarak bir model oluşturmak ve modelde yer alan değişkenler ile bu değişkenlerin çıktıya etkilerini açıklamak ise veri madenciliğinde esastır. Veri madenciliği sınıflama yöntemi kullanarak benzer özellikler gösteren gözlemleri kategorilere ayırmak ( tasnif etmek ) mümkündür. Bir örneği ise anlaşmalı boşanan çiftleri kategorilere ayırmak olabilir. Türkiye’de boşanan çiftlerin bir kısmı, sosyal güvenlik mevzuatında bulunan boşluğu kullanarak anne veya babadan dolayı kazanılan ölüm aylığını alabilmek için fiiliyatta gerçek olmayan sahte boşanma yapmaktadır. Mevzuatta bulunan hükümlere göre, evlendikten sonra boşanan kız çocukları da yetim sayılmaktadır ve yetim aylığı almaya hak kazanmaktadır. Ancak 5510 sayılı kanunun gelir ve aylık bağlanmayacak haller başlıklı 56 ncı maddesinin son fıkrasında eşinden boşandığı halde, boşandığı eşiyle fiilen birlikte yaşadığı belirlenen eş ve çocukların, bağlanmış olan gelir ve aylıkların kesileceği açıkça belirtilmiştir. Her ne kadar Türkiye’de bu şekilde yaşayan çiftlerin tespiti geleneksel denetim yoluyla yapılmaya çalışılsa da ilgili birimlerin bugüne kadar tespit edemediği benzer davranış gösteren kişiler bulunmaktadır. Veri madenciliği sınıflama teknikleri kullanılarak, bu kişilerin ortak özellikleri ve davranışlarını belirleyerek bir model oluşturmak ve kişilerin tespitinde ilgili birimlere yardımcı olmak ise bu çalışmanın temel amacıdır.
Self-similar solutions for fuzzy dark matter
Authors: Galazo-Garcia Raquel , Brax Philippe , Valageas Patrick
Published: July 2023

Self-similar solutions for fuzzy dark matter are very different from their counterparts in the standard cold dark matter model. In contrast to the familiar hierarchical collapse of the current model for structure formation, they correspond to an inverse hierarchical blow-up. This fact highlights the gravitational cooling process, which in the absence of dissipation, allows the system to eject excess energy through the intermittent expulsion of clumps of matter. These surprising behaviours are due to the wave properties of the Schrödinger equation and to the quantum pressure. These features are printed in the Eulerian density-velocity representation of the nonrelativistic scalar field, or in the Lagrangian representation in the mass-shell trajectories.
ELOISE - Reliable background simulation at sub-keV energies
Authors: Kluck Holger
Published: July 2023

CaWO_44 and Al_22O_33 are well-established target materials used by experiments searching for rare events like the elastic scattering off of a hypothetical Dark Matter particle. In recent years, experiments have reached detection thresholds for nuclear recoils at the 10 eV-scale. At this energy scale, a reliable Monte Carlo simulation of the expected background is crucial. However, none of the publicly available general-purpose simulation packages are validated at this energy scale and for these targets. The recently started ELOISE project aims to provide reliable simulations of electromagnetic particle interactions for this use case by obtaining experimental reference data, validating the simulation code against them, and, if needed, calibrating the code to the reference data.
‘General Slashchov’ [Rev. on: Ganin A. V. White General and Red Military Specialist Yakov Slashchov-Krymsky. Moscow, 2021]
Authors:   St. Petersburg State University, Puchenkov A. S.
Published: July 2023

The article describes the work prepared by the Moscow historian A. V. Ganin, the first scholarly biography of Ya. A. Slashchov, one of the most famous figures of the White movement in Southern Russia, a talented general and a prolific memoirist, the author of classic notes on the defense of the Crimea in 1920 and his relationship with the White dictator, General P. N. Wrangel. Slashchov is an exceptionally bright and charismatic figure, and evaluations of his activities are diametrically opposed, varying from enthusiastic to derogatory. Most clearly, Ya. A. Slashchov realised himself during the defense of the Crimea at the final stage of the Civil War in the South of Russia. A large number of myths have been formed around the figure of the general in memoirs — both about him as a military figure and about an administrator, and about him as a person. Thanks to the involvement of documents from seventeen archives from five countries, the book dispels many stereotypes, and recreates the life and professional path of Ya. A. Slashchov, from birth to death, in detail. Ganin describes unknown pages of Slashchov’s biography, in particular, the details of his service in the Russian Imperial Army, in the Nikolaevskaia Academy of the General Staff, as well as in the Volunteer Army in 1918–1919. The author manages to give a convincing explanation of the reasons for Slashchov’s success in the defense of the isthmuses of Crimea at the turn of 1919–1920. The undoubted merit of the monograph by A. V. Ganin are photographs illustrating a number of aspects of the book, in addition to documentary supplements, among which the memoirs of M. Mezernitskii, a regular soldier, a member of the White movement, who returned to his homeland with Slashchov at the end of 1921.
Engaging the health sector in climate-resilient WASH development
Authors: Marcus Hannah
Published: July 2023

The impact of climate change on water, sanitation, and hygiene (WASH) has driven an increased focus on climate-resilient WASH development. Evidence suggests that adaptation in the WASH sector is underway, but the progress is limited in certain domains and the participation of the public health community may be lacking. Using the Lake Victoria Basin (LVB) as a climate vulnerability setting for this analysis, this study aimed to identify factors that impede full engagement of the health sector in climate-resilient WASH development. In-depth semi-structured interviews were conducted with 13 WASH sector stakeholders across lakeside urban centers in Kenya, Uganda, and Tanzania. Several barriers to health sector engagement were identified including factors related to donor-driven financing and priority setting, a relative neglect of climate vulnerabilities associated with sanitation and hygiene, ministerial siloes, and broader systems of adaptation governance which compromise health sector leadership in climate adaptation. These results suggest room for expansion of interdisciplinary collaborations and deepened involvement of the health sector in WASH-related climate adaptation, which starts with addressing these and other barriers to full health sector engagement.
jogo mimético na Odisseia, de Homero, e em A odisseia de Penélope, de Margaret Atwood
Authors: Modesto Edcleberton , Matozo Silva Ívens
Published: July 2023

Este artigo traz uma análise comparativa entre a Odisseia (2011), de Homero, e A odisseia de Penélope (2020), de Margaret Atwood, no que se refere à importância da mímese e da verossimilhança através de Penélope. O trabalho analisa um entrelugar, suspenso pelo não dito que, sob o olhar da autora, desvela aspectos do texto homérico, enfocando, agora, não mais Ulisses, mas Penélope. A discussão é amparada à luz das teorias de Carvalhal (1991), Carreira (2008), Renaux (2009) e Castro e Oliveira (2017). Desse modo, nota-se que Penélope, na obra moderna, ganha voz no enredo e, portanto, suas ações são elevadas ao primeiro plano, o que outrora lhe fora negado na Odisseia, de Homero. Assim, este estudo possibilita pensar a literatura a partir de seu contexto representado nas obras e a função social que elas exerceram/exercem para a sociedade.
Um estudo do aparelho psíquico em “O Grande Inquisidor”, de Dostoiévski
Authors: De Aguiar Pinho Noah , Botoso Altamir
Published: July 2023

A proposta deste artigo é estudar o conto “O Grande Inquisidor”, que faz parte da obra Os Irmãos Karamázov, de Dostoiévski (2012), evidenciando os agentes do aparelho psíquico freudiano, que conformam a referida narrativa. Analisam-se as facetas dominantes do superego, assim como os fluxos do id e ego, em relação aos principais intentos das personagens, com o intuito de revelar que a crítica contida na obra literária se refere a questionamentos relacionados ao ser humano dominado e robotizado sob a figura de um “Inquisidor Invisível”. Parte-se do entrelaçamento entre a literatura e a psicanálise, o qual possibilita observar como estas áreas se relacionam para tratar de uma essência em comum que atua na sociedade, que pode evoluir ou retardar a harmonia social.