bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial Patterns in the Association between the Prevalence of Asthma and Chronic Obstructive Pulmonary Disease: Socioeconomic and Climate Indicators in a Mediterranean Region
Authors: Bentué Carmen , Mimbrero Marcos Rodrigues , González Jose María Llorente , Ariño Antonio Sebastián , Martín Marcos Zuil , Antón María Zúñiga
Published: August 2021

The World Health Organization endorses the study of diseases from the perspective of the Determinants of Health (DH). DH are known as the circumstances in which people are born and raised, the environment in which they grow up and age and their lifestyle. The aim of this study is to analyze the spatial behavior of the prevalence of chronic obstructive pulmonary disease (COPD) and asthma in 2017 in Aragon, a Mediterranean region in Spain, using a DH approach. The methodological process entailed building a spatial database collating sociodemographic and climate indicators, and then evaluating the spatial variability of the relationships between DH indicators and disease prevalence by combining the Principal Component Analysis (PCA), Geographically Weighted Regression (GWR) models and cartographic design techniques. GWR evidences both global and spatially varying relationships, although each prevalence behaves differently. Asthma seems closely tied to local climate patterns whereas COPD is largely influenced by the built environment. Consequently, the socioeconomic and climatic contrasts characterizing the study area translate into several DH scenarios leading to situations vulnerable to the prevalence of asthma and COPD. This differential DH behavior detected by local regression models is relevant to guiding and refining public health decision-making.
Construction of Immune-related lncRNA Prognosis Models and Development Related Networks and Drugs in LGG
Authors: Zhang Xiaoyu , He Xiaoqin , Xiong Lin , Xu Yangtao , Chen Wenliang , Liu Xin , Hu Xinyao , Xu Ximing
Published: August 2021

Glioma is the most important tumor of the nervous system. LncRNA plays an important role in the occurrence, development, and metastasis of glioma. The immune status of glioma plays an important role in its treatment and prognosis. In lower-grade glioma (LGG), based on the results of the Weighted correlation network analysis (WCGNA) of lncRNA, we used lasso regression, random forest model, and stepwise regression to establish the lncRNA prognostic model: 0.58349*CYTOR + 0. 47804*LINC01831 + 0. 24933*HOTAIRM1 + 0. 73600*AC022034 + 0. 62351*AC104407 = lncRNA model prognosis score (LMPS). Concomitantly, we explored the correlation of LMPS with the Estimation of STromal and Immune cells in MAlignant Tumours using Expression data (ESTIMATE), Tumor IMmune Estimation Resource (TIMER) infiltrating immune cells. We also established the reciprocal network of the model and verified the significant prognostic significance of the hub genes of the network and the significant impact on immunity. Finally, by connectivity Map (cMap) analysis, we obtained the drugs about the WCGNA module where the model is. Our study highlights the close role of the lncRNA model with patient prognosis, immunity, and clinical staging, and can guide immunotherapy. The network is constructed with the model as the core. Its core genes also have a guiding role in patient prognosis, immunity, and treatment. We identified loratadine and fidaxomicin as possible drugs.
Anti-predation Defense Traits of Daphnia are Associated With the Gut Microbiota Composition Shaped by Fish Kairomone
Authors: Liu Qi , Akbar Siddiq , Ding Zihao , Zhou Qiming , Gu Lei , Sun Yunfei , Yang Zhou
Published: August 2021

Background: Gut microbiota plays an important role in host physiology and fitness. The gut microbiota can promote host health by influencing life history traits, especially in arthropods. However, it is not clear whether the performance of host defense traits in response to predator pressure in natural food webs is related to their gut microbiota composition. In this study, we used Daphnia magna as a model organism to investigate the relationship of D. magna life history traits and gut microbiota alterations under predator kairomone based on 16S rRNA amplicon sequencing.Result: We showed that the microbiota composition of D. magna was significantly affected by their predator risk and development stage. The relative abundance of Comamonadaceae (mainly Limnohabitans sp.) significantly decreased in the presence of predator kairomone. Furthermore, the presence of predator kairomone significantly reduced the α diversity of gut microbiota in D. magna with the increase of instar. Among them, the OTUs belonged to Epsilonbacteraeota and Firmicutes in the presence of predator kairomone were significantly higher than those in the control group. The results of functional predictions showed that predation pressure promote the metabolic function of gut microbiota, such as metabolism of energy, cofactors, and vitamins. By analyzing the correlation between the induced defense traits of D. magna and the relative abundance of bacteria, we found that the increased abundance of Comamonadaceae, Moraxellaceae, and Flavobacteriaceae were linearly correlated with the partial defense traits of D. magna. Specifically speaking, body size was positively correlated with an increased abundance of Comamonadaceae, whereas spine length was negatively correlated with an increased abundance of Comamonadaceae but was positively correlated with increased Flavobacteriaceae abundance. Conclusions: Our results suggested that predation risk can affect the composition of the gut microbiota in D. magna, which may indirectly induce the production of defensive traits in D. magna. The results of this study revealed an important role of gut microbiota in the development of defensive traits of Daphnia in response to fish predators. The correlation between microbial abundance and defense traits is of great significance for further understanding the effect of host-microbiota interaction on individual anti-predation defense.
Mobile-Learning App to Improving Skills in the Design of Therapeutic Exercise Program: Perception, Satisfaction and Physiotherapy Student´s Demand
Authors: Pastora-Bernal Jose-Manuel , Moreno-Morales Noelia , Estebanez-Pérez María-José , Molina-Torres Guadalupe , Fernandez-Navarro Rocío , Martín-Valero Rocío
Published: August 2021

Background: E-learning tools for students in health sciences present low levels of barriers and benefits for the student and the educator. No evidence is available using e-learning tools to design therapeutic exercise program skills. Research and different uses of technology in physiotherapy students are justified. The present study aimed to evaluate perception and satisfaction with an e-learning tool in five Spanish physiotherapy Universities. To evaluate the students' perception as an innovative learning experience identifying aspects to be improved and their perception respect to traditional teaching. Methods: A descriptive study in five health sciences faculties in Spain during the 2018-2020 academic years. The use of the tool is carried out under the supervision of physiotherapy teachers in diverse disciplines.Results: Results confirm that an e-learning tool to design therapeutic home exercise program is considered a satisfactory and innovative instrument that brings improvements in the learning of physiotherapy students with a high degree of satisfaction. Students declare aspect to be improved. All items have been valued positively with an average score of 3.41 in the set of 20 questions. It is considered a useful and necessary tool, compatible with traditional education. Conclusions: Our research provides new knowledge using innovative technologies enhancing learning skills. Students strongly recommend the use of the e-learning tool along the physiotherapy academic period.
Potential Value of the Calibrated Automated Thrombogram in Patients After a Cerebral Venous Sinus Thrombosis; an Exploratory Study
Authors: Bruggen Myrthe van der , Kremers Bram , Oerle Rene van , Oostenbrugge Robert Jan van , Cate Hugo ten
Published: August 2021

Background: Cerebral venous sinus thrombosis (CVST) is a relatively rare, but potentially lethal condition. In approximately 15% of the patients, the cause of CVST remains unclear. Conventional clotting tests such as prothrombin time and activated partial thromboplastin time are not sensitive enough to detect prothrombotic conditions nor mild haemostatic abnormalities. The calibrated automated thrombogram (CAT) is a physiological function test that might be able to detect minor aberrations in haemostasis. Therefore, we aimed to detect the presence of a prothrombotic state in patients who endured idiopathic CVST with the CAT assay. Methods: Adult patients with an idiopathic, radiologically proven CVST that had been admitted during the past 3 years were included in this study. The control group consisted of age/gender matched healthy volunteers. Exclusion criteria were known haematological disorders, malignancy (current/past) or hormonal and anticoagulant therapy recipients. We obtained venous blood samples from all participants following cessation of anticoagulation. Using the CAT assay, we determined lag time, normalized endogenous thrombin potential (ETP), ETP reduction and normalized peak height. In addition, prothrombin concentrations were determined. Results: We found no significant differences in lag time (4.7 min [4.5-4.9] vs 5.3 min [3.7-5.7], p = 0.691), normalized ETP (142% [124-148] vs 124% [88-138], p = 0.222), ETP reduction (29% [26-35] vs 28% [24-58], p >0.999), and normalized peak height (155% [153-175] vs 137 [94-154], p = 0.056) between patients and their age/gender matched controls. In addition, prothrombin concentrations did not significantly differ between patients and controls (120% [105-132] vs 127% [87-139], p>0.999.Conclusion: Reasons for absent overt hypercoagulability within this study population may be the small patient sample, long time since the event (e.g. 3 years) and avoidance of acquired risk factors like oral contraception. Given the fact that CVST is a serious condition with a more than negligible risk of venous thrombosis event recurrence, exclusion of clinically relevant hypercoagulability remains a challenging topic to further study at the acute and later time points, particularly in patients with idiopathic CVST.
Some electrophysical properties of polycrystalline silicon obtained in a solar oven
Authors: Olimov Lutfiddin Omanovich , Anarboyev Iqboljon
Published: August 2021

The article describes the results of the study of the microstructure and some electrophysical properties of silicon obtained by re-melting in a solar oven. It was found that the granularity of polycrystalline silicon consists of Si atoms with a size of 10–15 µm, the roughness of its surface. Decrease in specific resistance at T≤600 K, increase in concentration of ionized input atoms and concentration of charge carriers, the position at Т∼600 ÷ 700 K is based on the decrease in the free path of the charge carriers as a result of thermal vibrations of the crystal lattice, the situation at T ≥ 700 K K was explained by the emergence of new recombination centers specific to localized traps. Polycrystalline silicon heated by sunlight does not create a barrier effect of traps localized in the grain boundary regions from polycrystalline silicon obtained by other methods. This can expand the possibilities of creating highly efficient semiconductor devices, solar cells, thermoelectric materials for micro- and nanoelectronics, photovoltaics.
Sinusitis Independently Predicts the Presence of Headache Following Endoscopic Transsphenoidal Resection for Pituitary Adenomas
Authors: Gu Jiayu , Chen Xiaoqun , Zou Yunzhi , Yang Shuo , Chen Siyu , Li Depei , Sai Ke , Mou Yonggao , Zhou Zhihuan , Jiang Xiaobing
Published: August 2021

Purpose Headache is common among patients with pituitary adenomas undergone endoscopic endonasal surgery (EES), but was seldomly concerned before. The present study aims to investigate the incidence and profile of risk factors of headache after EES.Methods A meta-analysis was performed to evaluate the occurrence proportions of postoperative headache in patients with pituitary adenomas. Then, a cohort of 101 patients undergone EES were enrolled for analyzing risk factors of headache. The Headache Impact Test (HIT-6) was used to score the headache preoperatively, 1 month and 3 months postoperatively. Results A total of 18 studies and 4442 participants were included for meta-analysis. The pooled occurrence proportion of postoperative headache was 29% (95% confidential interval: 20-38%). For the 101 patients enrolled in the present study, 26 (25.74%) of them had a HIT-6 scores of > 55 preoperatively, but decreased to 22 (21.78%) at 1 month, and 6 (5.94%) at 3 months, postoperatively. Multivariate analysis showed that pituitary apoplexy (OR=3.591, 95%CI 1.219-10.575, p=0.020) and Hardy's grade C-D (OR=21.06, 95%CI 2.25-197.02, p=0.008) were independently risk factors for preoperative headache. In contrast, postoperative sinusitis (OR=3.88, 95%CI 1.16-13.03, P=0.028) and Hardy's grade C-D (OR=10.53, 95%CI 1.02-109.19, P=0.049) independently predicted the presence of postoperative headache at 1 month. At 3 months postoperatively, the proportion of sinusitis tended to be higher in the headache group than the one in non-headache group (100% vs. 30.0%, p=0.070). Conclusion Headache is very common following EES for pituitary adenomas. Prophylactic management of postoperative sinusitis may help to alleviate postoperative headache.
Identifying Eight Ferroptosis-Related Signatures for Prediction of Hepatocellular Carcinoma Overall Survival
Authors: Luo Dandong , Tao Qiang , Jiang HuiJuan , Zhu JunLing , Zhang Ning , Zhu Yongmin , Wang Guannan , Li YuHua , Huang Yan
Published: August 2021

Background

Hepatocellular carcinoma (HCC) is characterized by widespread epidemiology and extraordinary heterogeneity, with challenging prognosis prediction. Ferroptosis is a regulatory cell death driven by iron-dependent lipid peroxidation. The main aim of this study was to determine the predictive value of ferroptosis-related genes (FRGs) in HCC.
Methods

Herein, the data of HCC patients were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) public databases. In the ICGC cohort, a multigenic signature was constructed using the LASSO Cox regression model. Next, patients in the TCGA cohort were used to verify the reliability of the model.
Results

Results showed that 30.07% of the differentially expressed genes (DEGs) in the ICGC cohort were associated with ferroptosis. Among them, 35 genes were identified as intersected genes associated with overall survival in both cohorts. Moreover, an 8-gene signature for prediction of HCC patients was constructed and the patients were divided it into low-risk and high-risk groups. The results indicated that the overall survival (OS) of patients in the high-risk group was lower than OS of patients in the low-risk group (P < 0.001 in both cohorts). Multivariate Cox regression analysis indicated that the risk score was an independent predictor of OS (HR > 1, P < 0.001). Receiver operating curves (ROC) demonstrated the predictive power of the signature. Furthermore, functional enrichment analysis revealed the existence of significantly correlated immune-related pathways, and their immune states were different between groups.
Conclusions

In summary, the genetic signature described in this study was associated with ferroptosis and it can be used to predict the prognosis of HCC. Therefore, targeted treatment of ferroptosis may be an alternative treatment option for HCC.
Methylation levels of LEP and POMC genes after intervention with dietary folate and hazelnut oil in the lipid profile of overweight women
Authors: Chaves Thamires , Lima Raquel , Ribeiro Marina , Luna Rafaella , Silva Débora , Oliveira Naila , Silva Ana Hermínia , Pisseti Cristina , Ferreira Flávia , Gonçalves Maria da Conceição , Almeida Aléssio , Moraes Ronei , Silva Alexandre , Lima Roberto , Costa Maria José
Published: August 2021

BackgroundObesity contributes to several cardiometabolic diseases, such as dyslipidemia, as a result of an unhealthy lifestyle and genetic factors. The methylation profile of genes involved in appetite control and metabolism, such as LEP (leptin) and POMC (proopiomelanocortin) and altered lipid levels can contribute to obesity, and these epigenetic changes have been associated with the effects of diet composition. The objective of this study was to evaluate the methylation levels of LEP and POMC genes and lipid profile values after intervention with dietary folate and hazelnut oil in overweight women.MethodsDouble-blind, placebo, controlled intervention study with 40 overweight adult women. Participants were randomized into four groups for 8 weeks: G1, 300 g of vegetables and 191 µg / day of folate and hazelnut oil; G2, 300 g of vegetables and 191 µg / day of folate and placebo; G3, 300 g of vegetables and 94 µg / day of folate and hazelnut oil; G4, the individuals were only accompanied. In addition to the levels of methylation, food consumption, anthropometric measurements, biochemical variables of lipid profile were evaluated.ResultsAfter the intervention, the participants presented reduction in the methylation levels of the studied genes in the three intervention groups in the LEP gene: G1 (p = 0.00), G2 (p = 0.00) and G3 (p = 0.00); in the POMC gene: G1 (p = 0.01), G2 (p = 0.02) and G3 (p = 0.01), and in the lipid profile, G1 reduced the levels of LDL-c (p = 0.04), HDL-c (p = 0.00) and Triglycerides (p = 0.04); in G3 there was a reduction in total cholesterol levels (p = 0.00), LDL-c (p = 0.00) and HDL-c (p = 0.00), and in G4 there was a reduction in total cholesterol values (p = 0.00), LDL-c (p = 0.00), HDL-c (p = 0.00) and triglycerides (p = 0.00), and also, an association in G2 between the POMC methylation levels with triglycerides (p = 0.00).ConclusionThe study provided evidence of a normocaloric intervention with dietary folate and hazelnut oil supplementation on the methylation levels of LEP and POMC genes and the role they can play in lipid metabolism.Trial registrationISRCTN, NCT04523532. Registered 21 August 2020, https://clinicaltrials.gov/ct2/show/NCT04523532
EVI-1-Mediated Up-Regulation of lncRNA TUG1 Interacts with miR-186-5p to Promote Proliferation and Drug Resistance in Pediatric Acute Myeloid Leukemia
Authors: Li Erwei , Liang Yu , Zhang Hongliang , Zhang Lina , Tang Yingying , Wanyan Yuanyuan
Published: August 2021

Background:Deregulated lncRNAs have been well-documented to be closely associated with resistance to chemotherapeutic agents in malignancies including acute myeloid leukemia (AML). Herein, we intended to explore the roles and underlying mechanism of lncRNA taurine-upregulated gene 1 (TUG1) in pediatric AML cell adriamycin (ADR) resistance.Methods:TUG1 and ecotropic viral integration site-1 (EVI-1) expressions in pediatric AML patients and cells were detected by using qRT-PCR and western blot, respectively. Western blot analysis, flow cytometry and CCK-8 assays were conducted for evaluating the drug sensitivity, apoptosis, and cell viability. Luciferase reporter assay and qRT-PCR were implemented to determine the interaction between miR-186-5p and TUG1. The western blot was employed to analyze the changes of proteins.Results:TUG1 was upregulated with a high positive correlation with EVI-1 in pediatric AML patients. TUG1 was transcriptionally activated by EVI-1 and functioned as a miR-186-5p ceRNA to inhibit its expression in AML cells. An enhanced cell proliferation as well as a resistance to ADR in HL60 cells was observed after TUG1 overexpression and miR-186-5p knockdown, while an opposite effect was elicited by TUG1 silencing and miR-186-5p restoration. Mechanistically, robust expression of TUG1 increased P-gp level and induced the PI3K/Akt/mTOR cascade activation in HL60 cells while loss of TUG1 expression exerted reverse effects in HL60/ADR cells. Moreover, TUG1 overexpression abolished miR-186-5p-induced inactivation of the PI3K/Akt/mTOR cascade in HL60/ADR cells.Conclusion:Taken together, in pediatric AML, EVI-1-mediated upregulation of the oncogenic lncRNA TUG1 promotes proliferation and ADR resistance by sponging miR-186-5p through the PI3K/Akt/mTOR signals.
Prevalence and Antibiotic Resistance Profile of Salmonella spp. in Broiler Carcasses From Dominant Poultry Production Areas in Bhutan
Authors: Penjor Kinley Penjor , Gurung Monu Gurung , Islam Kamrul Islam , Magalhaes Ricardo J. Soares Magalhaes
Published: August 2021

Background
Salmonella is an important zoonotic pathogen and its infections are considered among the most commonly and widely distributed food-borne illness reported worldwide. Poultry products have been identified as important sources of Salmonella infection to humans. While there have been reports of high prevalence of Salmonella and multidrug resistance in imported chicken meat in Bhutan, the safety of nationally produced broiler meat with regards to Salmonella contamination is not known. In the absence of national surveillance of Salmonella in food animals in Bhutan, this study assessed the prevalence of Salmonella and its serotypes in broiler chicken carcass in the dominant poultry production areas of the country and determine its antibiotic susceptibility patterns.
Methods
A cross-sectional study was conducted in January to April 2016 in all five major commercial broiler meat producers and suppliers in Bhutan located in the Samphelling and Darla gewogs. Following a systematic random sampling method, 36 broiler carcasses were sampled from each of the five broiler commercial farms producing the total sample size of 180 samples. Salmonella was isolated and identified following the International Organization for Standardization methods (ISO 6579:2002). All Salmonella isolates were subjected to antibiotic susceptibility testing (AST) following the procedures of the Clinical and Laboratory Standards Institute (CLSI) method.
Results
The overall prevalence of Salmonella in broiler chicken meat samples was 12.78% (95% CI, 10.98–14.58). The prevalence of Salmonella spp. was higher in farms of the Samphelling gewog compared to Darla gewog [14.81% (95% CI, 8.2.7–21.5) vs 9.72% (95% CI, 2.9–16.6) respectively]. Among 23 Salmonella isolates, the most prevalent serovar was S. typhi (73.9%). The Salmonella isolates showed high sensitivity to gentamicin (73.9% of isolates) followed by streptomycin (56.5%) and ampicillin (47.8%). The highest proportion of resistance was noted to tetracycline (95.6%), trimethoprim (86.9%), amoxicillin (65.2%), and ampicillin (47.8%). Among 23 Salmonella isolates, 60.87% (n = 14) were considered multidrug resistant and 7 patterns of multidrug resistance were discovered.
Conclusion
The estimates of Salmonella prevalence and multidrug resistance in nationally produced commercial broiler chicken carcasses from the two main broiler meat producing areas in Bhutan, raises significant public health concerns highlighting the need for an integrated national Salmonella surveillance program across the poultry market chain.
Impact of Dust Storm on the Atmospheric Boundary Layer over Ahmedabad, a Western Indian Region .
Authors: Saha Sourita , Sharma Som K , Chhabra Abha , Kumar K Niranjan , kumar prashant , Lal Shyam
Published: August 2021

The present study focuses on investigating the impacts of a sudden dust storm on the atmospheric boundary layer (ABL) over Ahmedabad (23.02°N, 72.57°E), an urban site located in the western region of India. The accumulation of dust in the atmosphere during the dust storm, originating from the Thar Desert in Rajasthan, led to the decrease in surface temperature as a consequence of dust-radiation interaction. Ambient particulate matter data obtained from Air Quality (AQ) station at Ahmedabad showed a spike of 118.5% and 44.5% in PM10 and PM2.5 concentrations, respectively during the event in comparison to the previous control day. Sudden exposure to an anomalous increase in particulate aerosols may cause severe impacts on human health. These surface forcing have been reflected in the stable nocturnal ABL. Backscatter signals recorded by ground-based Ceilometer Lidar at Physical Research Laboratory (PRL), showed that ABL was shallow and collapsed during the dust storm episode. Turbulence was detected in the ABL during the event which further assisted in the vertical mixing of dust aerosols in the ABL. These aerosols got trapped within the residual layer, preventing further percolation in the free atmosphere. Such sub-grid scale changes in the ABL during the dust storm were not reflected in the boundary layer height (BLH) obtained from the ERA-5 reanalysis dataset. A significant association between the ABL and the local radiative budget has been found. It has been substantiated by Coupled Ocean-Atmosphere Radiative Transfer Model (COART) simulations that showed a cooling of the surface. Thus, this study is important as it can be taken as feedback to improve local climate models with respect to dust storm meteorology.
SiGe based ROM-less 18.5 GHz clock direct digital synthesizer design and characterization
Authors:   , Shrestha Amit
Published: August 2021

The requirement of the versatile signal generator has always been evident in modern RF and communication systems. The most conventional technique, voltage control oscillator (VCO), has inferior phase noise and narrow bandwidth despite its operating frequency can be up to the sub-THz regime. Its phase noise influenced by a various parameter associated with the oscillator circuit e.g. transistor size \& noise, bias current, noise leaking from the bias supply etc. The bandwidth is limited because the input voltage \& the output frequency of the VCO is not strictly linear over the tuning range. The phase noise and SFDR of the VCO output are enhanced by using the phase-lock technique. The phase-locked loop (PLL) uses the feedback system locking the reference frequency set by the VCO. However, the settling time of the PLL is higher due to a feedback control loop. The higher settling time increases the frequency switching time between PLL outputs. IG-oscillators is suitable for multi-GHz range and wide bandwidth application. Signal generation can alos be achieved by the free-electron radiation, optical lasers, Gunn diodes as well and they can operate even at the THz domain. All these signal generators suffer from slow frequency switching, lack of digital controllability, and advance modulation capability even though their frequency of operation is THz regime. Alternatively, the AWG (arbitrary wave generator) can produce a wide range of frequencies with low phase noise, including digital controllability. One of the vital components of the AWG is the direct digital synthesiser (DDS). Generally, it is composed of a phase accumulator, digital to analogue converter, sine mapping circuits and low pass filter. It needs a reference clock that acts as samples of the DDS outputs. Its output frequency can be varied by applying an appropriate digital input code. But high-speed DDS has several limitations; such as low number of output frequency points, lack of phase control unit, high power consumptions etc. This work addresses such limitations.
Priority directions and ways for implementation of Ukraine's humanitarian policy systems
Authors: Pakhomov V.V. , Karikh I.V,
Published: August 2021

The article is devoted to the research of priority directions and ways of implementation of systematic foundations of humanitarian policy of Ukraine. The authors point out that the national security policy in the humanitarian sphere in Ukraine is based on a rather sound and developed scientific-theoretical, ideological and methodological base. The legal framework of such a policy in Ukraine is somewhat outdated, but it allows most of the functions of the state to protect national interests, preserve social guarantees of humanitarian infrastructure, interethnic and religious peace, assert national identity and educate patriotism, which are top priority. in Ukraine. At the same time, at the regulatory level, the humanitarian component of security policy in Ukraine does not yet have a clearly defined subject, it contains various aspects of state policy concerning, in particular, related spheres of social, environmental, information security, which complicates the methodological and administrative and organizational support for its effective implementation. The task of the state is to establish clear rules and principles that society as a whole will consider fair and will be ready to adhere to. In most issues of identity politics, this set of rules is already outlined. It is problematic to reduce humanitarian expenditures due to the proliferation of tax evasion in the private sector, corruption in the public sector, recurrent economic crises, and the effects of socio-political instability and external aggression. Considering these circumstances and factors forces us to reconsider some of the approaches and norms on humanitarian security of citizens that the Ukrainian state can and must now guarantee. It is concluded that the key task of improving the effectiveness of humanitarian security policy in Ukraine is to build a coherent system of interaction of the main subjects of such policy on a single methodological basis, common goals and principles of operation, agreed procedures, creative complementarily and ability to respond flexibly to changes in the environment.
On the issue of liability in economic judicial proceedings
Authors: Rudenko L.D.
Published: August 2021

The article specifies the legal nature of liability in commercial litigation, defines the ratio of measures of procedural coercion and liability in commercial litigation. Based on the analysis, a conclusion was made about the inexpediency of combining the measures of responsibility provided by the Commercial Procedural Code of Ukraine into an independent type of legal liability. The expediency of separating the category "Responsibility in commercial litigation" is argued. It is noted that the purpose of such liability is to comply with the procedural order of commercial proceedings under the threat of criminal, administrative, civil, disciplinary liability. Liability in commercial litigation includes all types of liability that are realized in connection with the implementation of such litigation: criminal, administrative, disciplinary liability of judges, lawyers, prosecutors, civil liability. Measures of such responsibility may have as their normative source not only the Commercial Procedure Code, but also the Criminal Code of Ukraine, the Code of Ukraine on Administrative Offenses, the Commercial Code, the Civil Code. It is noted that liability in commercial litigation is a complex legal institution. It is specified that measures of procedural coercion and liability in commercial litigation are forms of state coercion. Procedural coercion has a wider scope than liability in commercial litigation. The signs of procedural coercion in commercial litigation are specified: implementation regardless of the will of the subject to which they are applied; application by the court; implementation in connection with the implementation of legal proceedings in a particular case; ensuring the implementation of the tasks of commercial litigation; in some cases it is an unfavorable consequence of violation of the requirements of the legal norm (disposition), ie in connection with the implementation of dispositions of legal norms, in other cases it is the implementation of dispositions of legal norms that establish certain restrictions to ensure proceedings.
Foreign experience in ensuring the economic security of the state
Authors: Mirgorod-Karpova V.V. , Murach D.V.
Published: August 2021

The article highlights the experience of foreign countries in ensuring the economic security of the state. The main part of the work is devoted to the analysis of different models of government agencies to ensure the economic security of different countries. In the current conditions in which Ukraine finds itself, such as the severe economic crisis, the coronavirus pandemic, high levels of corruption and others, there is an urgent need for a rational and prompt response by the authorities to such obstacles to stability. Especially today, when due to the pandemic of coronavirus infection, which has caused unfavorable conditions for doing business and normal employment, the issue of mobilization of all economic forces to bring the country out of crisis is relevant. Potentially, such obstacles could significantly weaken Ukraine's economy for many years to come. The authors of the article propose to overcome this problem, to explore foreign models of bodies that provide financial and economic security. Thus, the key subject of research will be various foreign bodies that ensure the economic security of the country and doctrinal sources that cover the improvement of the current model of economic security in Ukraine and the world. Therefore, to ensure the appropriate level of economic security of Ukraine, it is necessary to conduct a comprehensive study of foreign experience in this area in order to attract and implement in national legislation certain ideas that may further positively affect the state of the national economy. The paper pays special attention to the introduction of a single law enforcement body to ensure economic security in Ukraine. Some opinions of legal scholars on the need to introduce such a body and the implementation of foreign experience in Ukraine are given. The authors pay special attention to the experience of the Financial Guard of Italy and the administrative and legal mechanism of its interaction with other public authorities.
Protection of intellectual property rights on a trademark
Authors: Zolota L.V. , Rusak G.V.
Published: August 2021

In the process of developing their own business, legal entities and individuals are looking for new ways and tools to separate, individualize goods or services from others. The most effective tool to individualize and promote business not only in domestic but also global markets is a trademark. Therefore, it is worth paying attention to the brand from the moment of business formation. After all, the consumer perceives the brand visually, phonetically, semantically, it is a tool that psychologically affects the consumer of a product or service and forces him to make a choice. Relations arising during the acquisition, exercise and protection of trademark rights are provided by the Constitution of Ukraine, the Civil and Commercial Codes of Ukraine, the Law of Ukraine "On Protection of Rights to Marks for Goods and Services", as well as relevant ratified international treaties and other regulations acts. Also, the relevance of this topic is due to the fact that the trademark is a special, unique object of intellectual property rights, a means to individualize goods and services, as well as business participants. Problems of trademark use and protection are a significant issue, as a necessary condition for effective economic development, increasing the level of product competitiveness, not only in Ukraine but also abroad, protection against unfair competition is the proper implementation of trademark rights. During the writing of the article to achieve the goal the concept of trademark in Ukraine and its features were revealed, differences of trademark from other marks for goods and services were established, the legislation of Ukraine in the field of trademark protection was analyzed and characterized trademark in Ukraine.
Continuity and Transformation of Rural Communal Temples in Vietnam: A Case Study of Tân Chánh Village, Long An Province
Authors: Ngo Thi Phuong Lan , Nguyen Ngoc Tho
Published: August 2021

Vietnamese communal temples (đình làng) were primarily established with two functions: (1) as a state-patronised institution to organise and control the village politically and culturally and (2) as a place of worship of village deities and meritorious predecessors. Both functions interact and complement each other – in many cases, the second serves as both a “means” and “technique” to deploy the first. However, nowadays the administrative role is no longer available; instead, the spiritual aspects are on the rise as a response to the increasing interaction of Buddhism, Caodaism, and folk beliefs as well as the impact of economic development and urban migration. Village elders learn to organise the temple into a communal socio-cultural institution, whereby cross-village temples have formed a cultural nexus of “power”. This study finds that while several transformed into the form of “temple of heroes”, Tân Chánh temple has been mobilised and transformed into a civic “religious and socio-cultural centre” at the grassroots level. The socio-economic background of the area has caused such transformation. While the practical demand for communication and emotional exchanges among village members vividly ensures the continuity of the temple’s tradition, the loss of direct state control paves the way for its transformation. Both continuity and transformation govern the current religious activities of Tân Chánh temple but there is always a challenge to compromise and integrate these two directions. However, the remaining function of god worship by which rituals are performed as “cultural agents” still binds the villagers together and gives them access to crossing boundaries.
Is a Miracle-less WIMP Ruled out?
Authors: Arakawa Jason , Tait Tim
Published: August 2021

We examine a real electroweak triplet scalar field as dark matter,
abandoning the requirement that its relic abundance is determined
through freeze out in a standard cosmological history (a situation which
we refer to as `miracle-less WIMP’). We extract the bounds on such a
particle from collider searches, searches for direct scattering with
terrestrial targets, and searches for the indirect products of
annihilation. Each type of search provides complementary information,
and each is most effective in a different region of parameter space. LHC
searches tend to be highly dependent on the mass of the SU(2) charged
partner state, and are effective for very large or very tiny mass
splitting between it and the neutral dark matter component. Direct
searches are very effective at bounding the Higgs portal coupling, but
ineffective once it falls below \lambda_{\text{eff}} \lesssim 10^{-3}λeff≲10−3.
Indirect searches suffer from large astrophysical uncertainties due to
the backgrounds and JJ-factors,
but do provide key information for \sim∼
100 GeV to TeV masses. Synthesizing the allowed parameter space, this
example of WIMP dark matter remains viable, but only in miracle-less
regimes.
Systematizing and addressing theory uncertainties of unitarization with the Inverse Amplitude Method
Authors: Salas-Bernárdez Alexandre , Llanes-Estrada Felipe , Escudero-Pedrosa Juan , Oller José Antonio
Published: August 2021

Effective Field Theories (EFTs) constructed
as derivative expansions in powers of momentum, in the spirit of Chiral Perturbation Theory (ChPT), are a controllable approximation to strong dynamics as long as the energy of the interacting particles remains small,
as they do not respect exact elastic unitarity.
This limits their predictive power towards new physics at a higher scale if small separations from the Standard Model are found at the LHC or elsewhere.
Unitarized chiral perturbation theory techniques have been devised to extend the reach of the EFT to regimes where partial waves are saturating unitarity, but their uncertainties have hitherto not been addressed thoroughly.
Here we take one of the best known of them, the Inverse Amplitude Method (IAM), and carefully following its derivation, we
quantify the uncertainty introduced at each step. We compare its hadron ChPT and its electroweak sector Higgs EFT applications.
We find that the relative theoretical uncertainty of the IAM at the mass of the first resonance encountered in a partial-wave is of the same order in the counting as the starting uncertainty of the EFT at near-threshold energies, so that its unitarized extension should a priori be expected to be reasonably successful. This is so provided a check for
zeroes of the partial wave amplitude is carried out and, if they appear near the resonance region, we show how to modify adequately the IAM
to take them into account.
Polynomial filter diagonalization of large Floquet unitary operators
Authors: Luitz David J.
Published: August 2021

Periodically driven quantum many-body systems play a central role for
our understanding of nonequilibrium phenomena. For studies of quantum
chaos, thermalization, many-body localization and time crystals, the
properties of eigenvectors and eigenvalues of the unitary evolution
operator, and their scaling with physical system size
LL
are of interest. While for static systems, powerful methods for the
partial diagonalization of the Hamiltonian were developed, the unitary
eigenproblem remains daunting. % In this paper, we introduce a Krylov
space diagonalization method to obtain exact eigenpairs of the unitary
Floquet operator with eigenvalue closest to a target on the unit circle.
Our method is based on a complex polynomial spectral transformation
given by the geometric sum, leading to rapid convergence of the Arnoldi
algorithm. We demonstrate that our method is much more efficient than
the shift invert method in terms of both runtime and memory
requirements, pushing the accessible system sizes to the realm of 20
qubits, with Hilbert space dimensions \geq 10^6≥106.
A influência do tipo de parto no desmame precoce
Authors: Medeiros Anna Carolina Lomelino Lemos , Silva Geisa Sereno Velloso da , Gomes Elisângela Nascimento Fernandes , Silva Jannaina  Sther Leite Godinho , Souza Alessandra da Silva , Silva Eliara Adelino
Published: August 2021

Objetivo: Analisar a relação do tipo de parto e sua influência sobre o desmame precoce. Materiais e Métodos: Trata-se de uma pesquisa exploratória e descritiva, de cunho bibliográfico e abordagem quanti-qualitativa, tendo como fontes de pesquisa as seguintes bases de dados: LILACS e BDENF. Resultados: A partir da busca nas bases de dados foi possível identificar três categorias: O Aleitamento Materno Exclusivo (AME); leis e políticas públicas que amparam o aleitamento materno no Brasil e por último, a influência do tipo de parto sobre o desmame precoce. Discussão: O leite materno é considerado o alimento ideal para a saúde, o desenvolvimento e crescimento do bebê, além do fortalecimento de seu vínculo afetivo com a mãe, fornecendo proteção, nutrição e vantagens imunológicas à criança, contribuindo para a redução da morbimortalidade infantil. Por isso, leis e políticas públicas foram delimitadas para que esse processo pudesse ser fortalecido. No entanto, a taxa de desmame precoce no país ainda se encontra alta.  Conclusão: O desmame precoce sofre forte influência por conta do tipo de parto, em especial a cesárea, que reduz pela metade a prevalência da amamentação na primeira hora de vida por conta do efeito da anestesia e dos cuidados no pós-operatório, aumentando o tempo de contato entre mãe e filho.
Palavras-chave: Desmame Precoce; Aleitamento Materno; Aleitamento Materno Exclusivo.
O Uso do Brinquedo Terapêutico na Vacinação
Authors: Santos Luany Mazoni , Silva Janaínna Sther Leite Godinho , Souza Alessandra da Silva , Silva Eliara Adelino da , Vieira Carolina de Lourdes Julião , Rodrigues Lília Marques Simões Rodrigues
Published: August 2021

Este estudo tem como objetivo descrever a utilização os brinquedos terapêuticos durante o processo de vacinação. Trata-se de um estudo qualitativo exploratório descritivo que foi realizado através de uma revisão integrativa de literatura. O estudo foi realizado mediante a buscas nas bases de dados BIREME, LILACS, MEDLINE e SCIELO, usando os descritores Enfermagem, Brinquedo Terapêutico, Saúde Pública e Vacinação com estudos publicados entre 2011 a 2019. Foi evidenciado durante o estudo que apesar das dificuldades na implantação da prática na vacinação, o enfermeiro pediatra deve utilizar o brinquedo terapêutico no cotidiano de trabalho e orientar a equipe de enfermagem que cuida diretamente da criança a técnica correta para que tenhamos bons resultados, onde a criança entenda o procedimento que está sendo realizado e possa perder o pavor que os mesmos tem na hora da vacinação.

Palavras-Chave: Brinquedo Terapêutico; Enfermagem; Saúde Pública; Vacina.
Os desafios dos enfermeiros para realização do Pré-Natal na Estratégia de Saúde da Família
Authors: Melo Vitória da Silva Gomes de , Gomes Elisângela do Nascimento Fernandes , Silva Eliara Adelino da , Rodrigues Lília Marques Simões , Silva Geisa Sereno Velloso da , Silva Cátia Maria Santos Diogo da
Published: August 2021

O presente estudo tem como objetivos identificar e analisar as dificuldades que os enfermeiros enfrentam para realizar uma assistência de enfermagem no pré-natal nas Estratégias de Saúde da Família e identificar quais as estratégias utilizadas nas Estratégias da Família para o pré-natal. Metodologia: Trata-se de uma revisão da literatura, de caráter descritivo e exploratório, com abordagem qualitativa. Através da revisão de literatura possibilita colocar o pesquisador em contato direto com tudo o que foi escrito ou dito sobre determinado assunto. O método deste estudo é o qualitativo, responde questões muito particulares, seu foco é de caráter subjetivo do objetivo analisado, trabalha aspectos da realidade que não são quantificados, busca compreensão das relações sociais. Resultados: Os desafios identificados nas pesquisas enfrentadas pelos enfermeiros para realização do pré-natal foram: a deficiência do acolhimento das mulheres, as fragilidades na qualificação profissional da equipe, a precariedade de recursos relativos a área física, recursos humanos e materiais nas unidades de saúde, o desconhecimento da comunidade sobre as atribuições do exercício profissional e da consulta de enfermagem. A principais estratégias para realização do pré-natal foram:  busca ativa das gestantes, grupo de gestantes, acolhimento humanizado da gestante e família e atualização da equipe. Conclusão: É evidente a necessidade da capacitação profissional, a conscientização da comunidade sobre as atribuições e a realização da consulta de pré-natal feita pelo enfermeiro, para ampliação da adesão das gestantes ao pré-natal, e que o mesmo seja satisfatório e de qualidade.
Palavras-chave: Enfermagem; Pré-Natal; Saúde da Mulher.
Ausência do homem no Pré-Natal da Parceira e no Pré-Natal do pai
Authors: Bueno Arianne Cardozo , Gomes Elisângela do Nascimento Fernandes , Souza Alessandra da Silva , Silva Jannaína Sther Leite Godinho , Silva Geísa Sereno Velloso da , Silva Thiago Augusto Soares Monteiro da
Published: August 2021

Tradicionalmente, o planejamento reprodutivo e as atividades em saúde referentes ao momento da gestação, parto e puerpério, eram voltadas apenas às mulheres, entretanto em 2011 o Ministério da Saúde (MS) normatizou o Programa de Pré-Natal do Homem, com vistas a reagir contra a desigualdade, estimulando a prática de uma paternidade mais ativa e cuidadora, além da prevenção de patologias. Dessa forma o trabalho tem o intuito de analisar a adesão do pai no acompanhamento do pré-natal da mulher e na realização do pré-natal do parceiro. Trata-se de um estudo de revisão integrativa, descritiva e exploratória na qual foi selecionado base de dados BIREME, MEDLINE, LILACS e BDENF no recorte dos últimos 5 anos. Os estudos indicam a ausencia do homem nos serviços de saúde, quando há inclusão do homem no acompanhamento do pré-natal, sua presença não é efetiva, a participação destes sucede passivamente, pois apontam o parceiro como ouvinte da assistência prestada à mulher, sua presença não ocorre de maneira ativa. Os fatores que contribuem para ausencia dos homens são: incompatibilidade no horário de atenedimento das unidades de saúde, fragilidade na capacitação dos profissioanais e desconhecimento do homem sobre seus direitos. Espera-se que os dados da pesquisa possa contribuir, para a reeorganização e reformulação no planejamento dos serviços, para ampliar a qualidade do atendimento, da saúde do homem e da adesão do pai no pré-natal da mulher e no pré-natal do homem.
Palavras-chave: Enfermagem; Paternidade; Pré-Natal.