bluuebunny/crossref_metadata_2025 huggingface dataset:
ВИКОРИСТАННЯ РІЗНИХ ВИДІВ БОРОШНА ДЛЯ ХЛІБОБУЛОЧНИХ ТА БОРОШНЯНИХ КОНДИТЕРСЬКИХ ВИРОБІВ В ЗАКЛАДАХ РЕСТОРАННОГО ГОСПОДАРСТВА
Authors: Сильчук Тетяна Анатоліївна , Кирпіченкова Оксана Миколаївна , Дочинець Інга Вікторівна
Published: November 2024

У статті проаналізовано хімічний склад різних видів борошна, зокрема рисового, пшоняного, кукурудзяного, вівсяного, гречаного, соргового. Обґрунтовано перспективи використання борошна з амаранту, яке містить велику кількість білку, харчових волокон, вітамінів, мікро- та макроелементів у технології хлібобулочних та борошняних кондитерських виробів. Показано, що борошно з амаранту має цінний хімічний склад та чинить позитивний вплив на організм людини в цілому. Основною відмінністю хлібобулочних та борошняних виробів з амарантового борошна є високий вміст білку, вітамінів, мінеральних речовин. Амарантове борошно не містить глютену, використовується для збагачення хлібобулочних та борошняних кондитерських виробів, а також для виготовлення цілого ряду безглютенових виробів. Досліджено фізико-хімічні та технологічні показники якості борошна з амаранту. Встановлено, що амарантове борошно містить у 5,6 разів більшу кількість золи в порівнянні з пшеничним борошном. Має дещо вищу кислотність, що потребує додаткових технологічних заходів при виготовленні хлібобулочних та борошняних кондитерських виробів. Встановлено, що гідратаційна здатність амарантового борошна вища на 19% порівняно з пшеничним борошном, що обумовлено високим вмістом клітковини, особливостями будови крохмальних зерен амарантового борошна. Визначено, що борошно з амаранту краще зв’язує вологу, має вищу гідратаційну здатність, тісто з нього менше розпливається, за рахунок зв’язування вологи крохмальними зернами і харчовими волокнами борошна. Завдяки цьому вироби з амарантового борошна мають кращу формоутримувальну здатність. Визначено перспективи використання амарантового борошна в технології хлібобулочних та борошняних кондитерських виробів, зокрема й в закладах ресторанного господарства. Це дозволить підвищити харчову та біологічну цінність готових виробів, надасть виробам оздоровчих та функціональних властивостей. Борошно з амаранту доцільно використовувати в технології хлібобулочних та борошняних кондитерських виробів для хворих на целіакію.
ІННОВАЦІЙНІ ПІДХОДИ ДО МОДЕЛЮВАННЯ БІОЛОГІЧНИХ ПРОЦЕСІВ І ЇХ ЗАСТОСУВАННЯ В ДИДАКТИЦІ ПРИРОДНИЧИХ ДИСЦИПЛІН
Authors: Дороніна Тетяна Олексіївна , Ахматова Наталія Олександрівна
Published: November 2024

Статтю присвячено проблемі інтеграції інноваційних підходів до моделювання біологічних процесів у дидактику природничих дисциплін в умовах цифрової трансформації освіти. Розглянуто ключові аспекти впровадження комп’ютерних симуляцій і моделей у навчальний процес, які значно підвищують ефективність засвоєння складних біологічних явищ і стимулюють активну участь учнів у дослідницькій діяльності. Висвітлено важливість біологічної освіти в умовах глобальних екологічних, соціальних і технологічних викликів, зокрема в контексті війни та післявоєнної відбудови, коли питання екологічної відповідальності та збереження здоров’я людини стають критичними. Зроблено огляд сучасних методик моделювання, що включають використання математичних моделей для прогнозування розвитку популяцій, а також моделі взаємодії популяцій. Вказано на роль статистичних методів у вивченні варіаційних параметрів, кореляційних і регресійних залежностей у біології, що значно розширює можливості аналітичної діяльності учнів. Відзначено також інші інноваційні інструменти, як-от використання віртуальних лабораторій, електронних підручників, мультимедійних засобів навчання, які підвищують інтерактивність і доступність освітнього процесу. Висвітлено переваги таких технологій, проте вказано на їхні недоліки, зокрема зменшення рівня комунікації між суб’єктами навчання, залежність від технічних ресурсів і ризик зниження точності під час віртуальних експериментів. Акцентовано на важливості поєднання традиційних експериментів із комп’ютерним моделюванням для досягнення комплексного підходу у вивченні біологічних процесів, що дає можливість більш глибокого розуміння предмета. Відзначено потребу в належній методичній підтримці та підготовці педагогів для ефективного впровадження інноваційних технологій у процес навчання. Вказано на значення розвитку міжпредметних зв’язків, зокрема між біологією та математикою, через використання електронних таблиць і автоматизованих розрахунків у навчанні. Зроблено висновок, що подальші дослідження мають зосереджуватися на вивченні впливу інноваційних технологій на когнітивний розвиток учнів, формування критичного мислення й екологічної свідомості, а також на вдосконаленні методик для забезпечення доступності комп’ютерного моделювання в різних навчальних умовах, включаючи дистанційне та гібридне навчання.
ВІЗУАЛІЗАЦІЯ НАВЧАЛЬНОГО ПРОЦЕСУ НА ПРАКТИЧНИХ ЗАНЯТТЯХ З БОТАНІКИ ДЛЯ ЗДОБУВАЧІВ ОСВІТИ АГРОНОМІЧНОГО ФАКУЛЬТЕТУ
Authors: Кузнецова Ольга Всеволодівна
Published: November 2024

Підвищення ефективності подання, сприйняття інформації, її засвоєння на довготривалий час здобувачами освіти нового покоління є основною метою контексту опанування нових знань. Тому з усією необхідністю постає питання про збагачення навчального процесу ефективними освітніми ресурсами. У статті акцентовано увагу на візуалізації як сучасному методі засвоєння нового матеріалу природничих дисциплін для його довготривалого запам’ятовування. Запропонований робочий зошит як можливість опанування нової інформації у графічній формі, перетворення текстових даних на форму малюнків, анімаційних послідовностей, таблиць, схем. У фізіологічному аспекті в разі його використання спрацьовує зорова пам’ять як найкращий помічник запам’ятовування на рівні підсигнальної нервової системи. Після заповнення здобувачем освіти в робочому зошиті всіх зображень і підписів на час закінчення роботи відбувається швидке перетворення візуальних зображень на довгострокову пам’ять. Робочий зошит було створено для допомоги здобувачам освіти та викладачам у підготовці до практичних занять і виконання самостійної роботи з дисципліни. Кожен його розділ відповідає темі навчального плану дисципліни, має структурованість, послідовність, системність викладеного матеріалу. Матеріал структурується за організаційними, методологічними, теоретичними, аналітичними підрозділами, підрозділом висновків і проєктування. Кожний розділ має чіткий алгоритм для вивчення матеріалу, містить якісний ілюстративний матеріал. Забезпечено легке з’єднання більш простого основного матеріалу на початку з більш складним у кінці. У процесі залучення цього навчального компоненту спостерігались активізація та стабілізація уваги здобувачів освіти на інформації, поліпшення її сприйняття, запам’ятовування в часі, підвищення інтересу, навчальної мотивації. Публікація покликана окреслити переваги використання робочого зошита як пошуку одного з методів навчання здобувачів освіти агрономічних факультетів, як допомоги викладачам організувати самостійну роботу під час практичного заняття та позааудиторну підготовку.
ЕКОРЕГІОНИ УКРАЇНИ: ТЕРИТОРІЯ, НАСЕЛЕННЯ, ПРИРОДНО-РЕСУРСНИЙ ПОТЕНЦІАЛ
Authors: Руденко Степан Валерійович , Руденко Валерій Петрович , Пахомов Олександр Євгенійович
Published: November 2024

Тріада: територія, населення та природно-ресурсний потенціал (ПРП) розглядається як основа «скрупульозного екологічного кадастру кожної ландшафтної екосистеми». Висвітлюються результати оцінювання території (акваторії), населення та природно-ресурсного потенціалу по кожних із 57 природних екосистем обласного рівня, 14 провінційних екосистемах, 3 підзонах, 4 зонах і 3-х країнах (біомах) України. Стверджується, що оцінювані території (акваторія), населення та природно-ресурсний потенціал мають значні просторові відмінності серед екорегіонів різного ієрархічного рівня. Серед таксонів високого рангу – біомних екосистем – природних країн найбільшими диспропорціями відзначаються Кримські гори. Вони охоплюють усього 0,7% території (акваторії), проте зосереджують 2,82% населення України, де розміщується 1,9% природно-ресурсного потенціалу держави. Значно менші відміни в Українських Карпатах, відповідно – 6,3, 8,16 та 6,4%. Практично врівноваженим розподілом «території – населення – природно-ресурсний потенціал» характеризується Східно-Європейська рівнина: 93,0, 89,02, 91,7%. За цими ж показниками біоми – природні зони України розмістились: від найменших – у Зоні широколистяних лісів, Зоні мішаних лісів, Лісостеповій зоні, до найбільших – у Степовій зоні. Місткість провінційних екосистем України за сумарною часткою території (акваторії), населення і природно-ресурсного потенціалу зростає в такій послідовності (від найменших до найбільших показників): Кримська гірська провінційна екосистема, Причорноморсько-Приазовська, Кримська степова, Задонецько-Донська, Східно-Українська, Причорноморська, Гірський край – Українські Карпати, Лівобережно-Дніпровська, Лівобережно-Дніпровсько-Приазовська, Дністровсько-Дніпровська, Західно-Українська, Донецька, Подільсько-Придніпровська, Поліська провінційні екосистеми. Серед екосистем обласного рівня за величиною території, населення та природно-ресурсного потенціалу до десятьох найбільших (у порядку спадання) належать: Південно-Придніпровська схилово-височинна область, Донецька височинна, Старобільська схилово-височинна, Західно-Донецька схилово-височинна, Орільсько-Самарська низовинна, Харківська схилово-височинна області, область Житомирського Полісся, Кінсько-Ялинська низовинна область, область Волинського полісся, Передкарпатська височинна область. Найменшими за територією, населенням і природно-ресурсним потенціалом обласними екосистемами України є (у порядку спадання): Вододільно-Верховинська, Нижньобузько-Дніпровська низовинна, Гірсько-Кримська, Південнобережно-Кримська, Мармароська області.
MODEL SISTEM ANTRIAN UINSA MART MENGGUNAKAN POLA SINGLE CHANNEL SINGLE PHASE
Authors: Choirun Nisa Nila , Wahyu Alfian , Samudra Aryo , Fatoni Rizal
Published: November 2024

Simulation and modeling using a single channel single phase aims to optimize the cashier queuing system at Uinsa Mart. Queuing is a common phenomenon in everyday life where customers have to wait to get service. Delays in queues can affect the customer experience. This method uses literature studies, field studies, system implementation, and provides solutions. Observations were made to collect data regarding arrival time, service time, and other related variables. The data is processed and used as input to create a simulation model using Anylogic software. Queuing can be applied in the context of a canteen and provides recommendations for improving the queuing system at Uinsa Mart. Provides information about the observed queuing system, as well as the queuing model simulation that has been implemented. Provides further understanding of queuing system optimization and its application in the canteen context.
SECURITY SISTEM PADA BRANKAS DENGAN KARTU E-KTP DAN PASSWORD BERBASIS GERBANG LOGIKA MENGGUNAKAN KOMBINASI IC TTL
Authors: Muarif Muarif , Mardiansyah Mardiansyah , Romdhoni Romdhoni
Published: November 2024

A safe is designed to securely store valuable items, including important documents, jewelry, money, and other precious belongings. Modern safes often feature manual or semi-automatic locking systems, such as combination locks or cylinder locks. However, combination locks can be less secure and efficient, making them vulnerable to theft. In Indonesia, the adoption of RFID (Radio Frequency Identification) technology, especially in E-KTP cards, has seen progress, though its potential remains underutilized. This research integrates an advanced logic gate circuit using IC gates—AND, XOR, and NOT—functioning as a password mechanism. The device operates by requiring users to tap their E-KTP against a reader to unlock the safe door. Upon a successful tap, an LCD screen displays relevant information and requests a 16-bit binary password made up of 8 "1s" and 8 "0s." Users have 20 seconds to input the correct password; exceeding this time will reset the system, prompting another E-KTP tap. If an unregistered E-KTP is used, access is denied. The RFID reader, functioning at a frequency of 13.56 MHz, can read the E-KTP ID from a maximum distance of 1.3 cm. The integrated circuit logic will output HIGH only when the entered binary password matches the pre-set code within the safe, ensuring a secure and efficient locking mechanism for valuable items.
SISTEM KEAMANAN DOOR LOCK BERBASIS VOICE RECOGNITION DENGAN NATURAL LANGUAGE PROCESSING
Authors: Mutiara Syafrizal  , Vidya Ikawati  , Agus Siswanto  , Lestari Nina
Published: November 2024

Door lock security system based on voice recognition with natural language processing (NLP) is an innovation and innovative solution in improving home security and comfort using the internet of things (IoT). This research aims to develop and implement a security system that can recognize and process sentence variations to open or close doors with high success rate. The system uses ESP32 Dev Kit V1 microcontroller, MQTT communication protocol to send data, and integrates relays, solenoid door locks so that the system can operate efficiently and reliably. System testing shows that voice recognition and NLP can identify voice commands in human a special card or tag. The test results show that the system can accurately control the solenoid door locks based on the received commands. This research can contribute to the development of a more advanced and convenient home security systems.
Analysis of The Influence of Capital, Non-Performing Loans, Efficiency, Liquidity, and Net Income on Profitability
Authors: Muslihatun Annisa , Winarni Winarni , Santosa Teguh Budi
Published: November 2024

The study aims to analyze the effect of CAR, NPL, BOPO, LDR, and NIM on Profitability at Bank Neo Commerce simultaneously and partially. The research population is the financial statements of Bank Neo Commerce for the period 2013-2022. The sampling technique used saturated sampling technique and obtained 40 data. The data analysis method uses multiple linear regression. Data analysis techniques using the F Statistical Test, t Statistical Test, and the Coefficient of Determination (R2). The results show CAR, NPL, BOPO, LDR, and NIM simultaneously have a significant effect on ROA Bank Neo Commerce. The t test results show that BOPO and NIM have a significant effect on ROA Bank Neo Commerce. CAR, NPL, and LDR have no significant effect on ROA Bank Neo Commerce. Adjusted R2 of 0.977, shows the contribution of the influence of the independent variable on the dependent variable of 97.7% and the rest is explained by other variables not examined.
Tingkat Kesehatan Bank yang Terdaftar Dalam Indeks Infobank15 Tahun 2019-2022
Authors: Frederich Ryozky , Syafri Syafri
Published: November 2024

Bank perlu menjaga kepercayaan nasabah dengan mempertahankan kinerja mereka, yang dapat diukur melalui status kesehatan bank. Penelitian ini dilakukan untuk”mengukur nilai kesehatan bank yang terdaftar dalam indeks infobank15 dari 2019 sampai 2022 menggunakan metode RGEC”. Dalam penelitian ini digunakan “metode analisis deskriptif dengan pendekatan kuantitatif”. Dan untuk pengumpulan sampel menggunakan teknik purposive sampling, sehingga terdapat enam bank yang menjadi sampel penelitian, yaitu “Bank Central Asia, Bank Negara Indonesia, Bank Rakyat Indonesia, Bank Pembangunan Daerah Jawa Barat dan Banten, Bank Mandiri, dan Bank Pan Indonesia”. Hasil penelitian ini menggambarkan bahwa tingkat kesehatan keenam bank tersebut adalah “Sangat Sehat”, seperti yang dapat diketahui dari data kesehatan masing-masing bank, meskipun terdapat bank yang mengalami penurunan tingkat kesehatan pada tahun 2020.
Kualitas Laporan Keuangan UMKM: Analisis Empiris Menggunakan Enterprise Theory Kontekstual
Authors: Purwanto Setiyo , Retno Wuryandari Nur Endah
Published: November 2024

The growth of MSMEs as the foundation of the Indonesian economy requires increasing their capacity and capabilities. The aim of this research is to evaluate factors that influence the quality of financial reports. The importance of this research lies in the effort to provide knowledge that quality financial reports are very useful for measuring, analyzing and evaluating business performance whether profit or loss and as a basis for decision making. Based on bibliometric analysis, this research explores the variables of length of business, understanding of accounting, and accounting information systems on the quality of financial reports. This research uses a quantitative analysis method with a sample of 100 respondents from MSME actors around DKI Jakarta. The data was processed using the SmartPLS 3.3 statistical application program analysis. Research findings show that length of business and understanding of accounting do not guarantee that you can present quality financial reports. However, by utilizing an accounting information system, financial reports can provide accurate data information as a basis for decision making.
Deep Neural Networks in Medical Imaging: Advances, Challenges, and Future Directions for Precision Healthcare
Authors: Abir Shake Ibna , Shaharina Shoha  , Sarder Abdulla Al shiam  , Md Shah Ali Dolon  , Abid Hasan Shimanto  , Rafi Muhammad Zakaria  , Md Atikul Islam Mamun
Published: November 2024

This paper aims to provide a systematic review of the state of the art in the use of deep neural networks (DNNs) in medical imaging, an area that has been recently developed because of the emergence of artificial intelligence (AI) and machine learning (ML). Deep Neural Networks including Convolutional Neural Networks (CNNs) and Generative Adversarial Networks (GANs) have shown excellence in handling of a gigantic imaging data and assisting in diagnostics, treatment planning and patient care. This review also focuses on the breakthroughs of DNNs in different imaging tasks including classification, segmentation, registration, and detection, and has highlighted its potential to enhance diagnostic accuracy in different organs like the brain, lung and chest. Some of the key problems related to DNN deployment are also considered, including the problems that arise due to limitations of data, computational power, and model interpretability. That is why innovations such as transfer learning and synthetic data acquisition contributed to reducing these problems, thereby improving model performance with limited data. The paper concludes by discussing future works where the emphasis is made on the higher interpretability of the models and the combination of clinical records with images. In this paper, we attempt to offer a comprehensive review of the latest developments in DNNs in medical image analysis and delineate potential research directions to help researchers and practitioners interested in applying DNNs for medical imaging tasks.
Retrospective study of congenital anomalies of cattle and goats in selected areas of Mymensingh and Netrokona districts of Bangladesh
Authors: Azad Abdus Samad , Safawat Mst Sanjida , Juyena Nasrin Sultana
Published: November 2024

Background: Ruminants, especially cattle and goats, are prone to a wide range of congenital anomalies influenced by dietary, genetic, or environmental factors. Understanding these anomalies is essential for improving animal health and productivity. This study aimed to identify congenital defects in calves and kids across three upazilas in Bangladesh and to analyze their occurrence concerning breed, sex, and season.
Methods: Retrospective data on species, sex, breed, and season (summer, rainy, and winter) were collected from the register books of the Veterinary Teaching Hospital (VTH), Bangladesh Agricultural University, Mymensingh; Upazila Veterinary Hospital, Mymensingh Sadar, Mymensingh; and Upazila Veterinary Hospital, Kendua, Netrokona, spanning July 2013 to June 2023. Among 1159 cases, 1050 involved calves, and 109 involved kids. Data were analyzed using the Chi-square test in SPSS version 20.
Results: The most prevalent congenital anomaly identified was umbilical hernia (52.6%), followed by dermoid cyst (21.4%), atresia ani (15%), persistent urachus (5.8%), knuckling (3.4%), and rectovaginal fistula (1.8%). Both cattle (55.8%) and goats (57.8%) showed a higher prevalence of anomalies in males. Specifically, atresia ani, dermoid cyst, and umbilical hernia were more common in male calves, with occurrences of 62.4%, 57.35%, and 52.9%, respectively, while persistent urachus was found predominantly in males (80.3%). Knuckling was slightly more prevalent in females (52.8%), and rectovaginal fistula occurred exclusively in females. Regarding breed, persistent urachus was more frequently observed in indigenous breeds (55.7%), while atresia ani and rectovaginal fistula showed high frequencies in indigenous calves, with 65% and 63.2%, respectively. Conversely, dermoid cyst, umbilical hernia, and knuckling were more common in crossbred animals, occurring at frequencies of 55.6%, 60%, and 55.6%, respectively. Seasonal variations also played a role, with atresia ani most frequent in the rainy season (35%), while all other anomalies showed their lowest occurrences during this season. Persistent urachus was most prevalent in winter (41%), while dermoid cyst, umbilical hernia, and rectovaginal fistula were most common in summer, with frequencies of 38.2%, 39.7%, and 42.1%, respectively. Additionally, cattle exhibited a higher occurrence of congenital anomalies in crossbred calves during summer, whereas Black Bengal kids were more affected during winter.
Conclusion: Calves exhibited a higher occurrence of diverse congenital anomalies, with umbilical hernia being the most common, while kids were predominantly affected by atresia ani. Anomalies were more frequently observed in male animals and during the summer season.
THE EFFECTIVENESS OF KTMDU TRACKING IN AN EFFORT TO IMPROVING TAXPAYER COMPLIANCE
Authors: Rifqi Najmuddin Hilmi
Published: November 2024

Paying taxes is a citizen's obligation that is carried out by every individual who is forced. If citizens do not pay taxes, the country's infrastructure development will be hampered. In Sumedang Regency itself, there are still many motorised vehicles that do not conduct annual re-registration (KTMDU) by their owners even though vehicle tax is one of the sources of regional income that must be taken into account. This study aims to analyse and describe how the effectiveness of KTMDU tracing, analyse the factors that hinder the effectiveness of KTMDU tracing, and find out efforts to overcome the inhibiting factors of the effectiveness of KTMDU tracing in increasing taxpayer compliance. The research method used is descriptive research with a qualitative approach. The research data analysis technique is by collecting data that has been obtained by researchers from interviews, manuscripts, observation, and documentation. The effectiveness of KTMDU tracing in an effort to improve taxpayer compliance in the Sumedang Region can be said to be quite good, although in its implementation it is still not fully optimal. With the existence of inhibiting factors in the effectiveness of KTMDU tracing, the implementation of KTMDU tracing plans to make efforts to minimise inhibiting factors such as continuing communication, information and education.
Infections in sickle cell disease
Authors: Scourfield Lily E A , Nardo-Marino Amina , Williams Thomas N , Rees David C
Published: November 2024

Sickle cell disease (SCD) is one of the commonest severe inherited disorders in the world. Infection accounts for a significant amount of the morbidity and mortality, particularly in sub- Saharan Africa, but is relatively poorly studied and characterized. Patients with SCD have significant immunodeficiency and are more likely to suffer severe and life-threatening complications of infection, and additionally infections can trigger complications of SCD itself.
Those with more severe forms of SCD have functional asplenia from a very early age, which accounts for much of the morbidity in young children, particularly invasive infections from encapsulated bacteria including Streptococcus Pneumoniae, Haemophilus Influenzae, Salmonella Typhi and meningococcal disease. Additionally, there are other defects in immune function in SCD, associated with anemia, tissue infarction and impaired adaptive immunity.
Complications of infections in SCD include acute chest syndrome (ACS), acute painful episodes, osteomyelitis, meningitis, urinary tract infections, overwhelming sepsis and death. Viral infections cause significant morbidity, particularly severe anemia associated with Parvovirus, and to a lesser extent other infections such as influenza and COVID19. The relationship between malaria and SCD is complicated and discussed in this review.
Unlike many of the genetic risk factors for poor outcomes in SCD, it is theoretically possible to modify the risks associated with infections with established public health measures. These include the provision of vaccinations, prophylactic antibiotics and access to clean water and mosquito avoidance, although current financial restraints and political priorities have made this difficult.
Predictors and implications of renal injury after CD19 chimeric antigen receptor T-cell therapy
Authors: Boardman Alexander P , Gutgarts Victoria , Flynn Jessica , Devlin Sean M , Goldman Adam , Tomas Ana Alarcon , Fein Joshua A , Slingerland John B , Parascondola Allison , Lin Richard J , Scordo Michael , Dahi Parastoo B , Giralt Sergio , Palomba M. Lia , Salles Gilles , Nath Karthik , Walji Moneeza , Corona Magdalena , Park Jae H , Shah Gunjan L , Perales Miguel-Angel , Jaffer-Sathick Insara , Shouval Roni
Published: November 2024

Chimeric Antigen Receptor (CAR) T cells targeting CD19 induce durable remissions in patients with relapsed or refractory non-Hodgkin lymphoma (NHL), but many patients experience treatmentrelated toxicity. Cytokine release syndrome and immune effector cell-associated neurologic syndrome are extensively characterized. However, limited data exist on the burden, predictors, and implications of acute kidney injury (AKI) after CAR T cell therapy.
On initial screening of the FDA adverse event reporting system, we identified a disproportionately high rate of renal adverse events among nearly 6,000 CAR T adverse event reports, suggesting it is clinically important in this patient population. In a subsequent single-center analysis of 399 NHL patients treated with CD19 CAR T cells, we found a substantial burden of AKI after CAR T infusion (10% and 5% of any grade and grade ≥2 AKI) with pre-renal causes being predominant (72%). Evolution to chronic kidney disease was rare, however, 3 patients required hemodialysis. Importantly, patients experiencing cytokine release syndrome and/or neurotoxicity as well as those with low serum albumin and high inflammatory cytokines, including IL-6 and TNF-alpha, were more likely to develop AKI. While pre-CAR T renal dysfunction was not associated with adverse outcomes, patients developing post-CAR T AKI had lower overall survival compared to their counterparts.
Our findings indicate that renal dysfunction is a common toxicity of CAR T cell therapy with meaningful prognostic impact. Notably, the link between systemic inflammation and renal dysfunction, suggests that readily available biomarkers may inform on renal injury risk after CAR T cell therapy.
Calaspargase pegol and pegaspargase cause similar hepatosteatosis in mice
Authors: Ruiz-Torres Veronica , Chia Jennifer J. , Cohen Michael , Tan Jia , Rushing Teresa , Tinajero Jose , Orgel Etan , Mittelman Steven D.
Published: November 2024

Not available.
Postoperative Nosocomial Infections and Antimicrobial Resistant Pattern of Bacteria Isolated Among Patients Admitted at Ad-din Women's Medical College Hospital, Dhaka
Authors: Akter Mursheda , Lutfor Afzallunessa Binte , Hassan Munir , Chowdhury Ferdausi , Nug Arpita , Akter Nayeema , Shaha Shimu , Rahman Musrat
Published: November 2024

Objective: To find out the causative agents and antibiotic resistant pattern of organisms isolated from surgical site wound infection.
Place of study: This study was carried out in microbiology department, Ad-din Women's Medical Collage, Moghbazar Dhaka.
Method of study: The was carried out from January to December 2011 in microbiology department Ad-din women's medical college hospital. One hundred and thirty three clinically suspected surgical site wound infection cases were included in the study. Wound swab sample from surgical site was collected by sterile cotton swab. All the samples were immediately sent to the microbiology laboratory. Culture and sensitivity were done by standard bacteriological method.
Result: Out of 133 SSIS cases, 82(51.57%) were culture positive. Out of 82 culture positive cases, 38(45.23%) were Gram positive and 46 (54.76%) were Gram negative. Predominant organisms were Esch.coli 20(23.80%) and Staphylococcus aureus 20 (23.80%). Most of the organisms were resistant to Cephalosporin group while Carbapenem, Colistin, Piperacillin Tazobactum and Amikacin showed low level of resistance. Quinolones were more effective against Gram positive than Gram negative bacteria. Methicillin resistant Staphylococcus aureus were 11 (55%).
Conclusion: Esch.coli and Staphylococcus aureus were the major pathogen isolated from SSIS in our study. Cephalosporins were least effective drug. Carbapenem is the most effective drugs. For prevention of SSIS reinforcement of infection control policy for the health care worker is very important.
J. Dhaka National Med. Coll. Hos. 2013; 19 (01): 25-31
A postmortem study of length and internal diameter of the cystic duct
Authors: Khan Laila Farzana , Naushaba Humaira , Alam Jahangir , Qasim Rubina , Khan Khusruba Rahman
Published: November 2024

The cystic duct arises from the neck of the gallbladder and ends by joining with the common hepatic duct to form the common bile duct. Gallstones are frequently squeezed into the cystic duct and leads to spasm of the duct wall producing severe biliary colic. So, length and internal diameter of the cystic duct is very important for the surgeon for better management. This is an observational, descriptive type of study which was carried out in the Department of Anatomy, Sir Salimullah Medical College, Dhaka from July 2010 to June 2011. The number of sample was 62 postmortem human gallbladder with cystic duct which were collected from unclaimed dead bodies of the morgue of Dhaka Medical College and Sir Salimullah Medical College. The samples were divided into three different age groups. i.e. group A (10-20 yrs), group B (21-40 yrs) and group C (41-70 yrs). Morphological study was carried out on all samples by fine dissecting method. Statistically significant difference were found when values were compared between different age groups except the internal diameter of the cystic duct when group B was compared with group C, the result was found not significant (P>0.05). There was change in length and internal diameter of the cystic duct in relation to age.
J. Dhaka National Med. Coll. Hos. 2013; 19 (01): 35-38
Some Fascinating Anatomical Etymologies
Authors: Uddin Md Mesbah , Jahan Sharmin , Hassan Munir
Published: November 2024

Abstract not available
J. Dhaka National Med. Coll. Hos. 2013;19 (01): 3-5
A Study on Lipid Profile Status In Hypothyroid Patients And Its Consequences
Authors: Sarkar Mohammad Abdus Sattar , Salma Umma , Rahman Motlabur , Mahbub Tania , Shahi Selim , Khanam Shahana , Azhar Md Abu
Published: November 2024

This cross-sectional study was conducted to compare lipid profile status in hypothyroid patients attending at indoor and outpatient Department (OPD) of Medicine and Endocrinology, Sir Salimullah Medical College & Mitford Hospital, Dhaka over a period 6 months from March  to September 2008. A total of 80 patients (of which 30 patients formed the control group) aged 12 to 60 years, not taking thyroxin in the last 3 months and not taking lipid lowering agents were included in the study. Patients with secondary hypothyroidism, chronic renal failure, liver diseases, pregnancy, dyslipedamia (with or without lipid lowering agents) were excluded from the study. Data collected on variables of interest were analyzed using Chi-squared (c2) or Fisher`s Exact Probability tests, Student’s t-test and person correlation co-efficient test was done to see the correlation of lipid profile with the severity of hypothyroidism. The mean value of TSH, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglyceride in case group were significantly higher than those in control group but the mean high density lipoprotein cholesterol (HDL-C) was lower in case group compared to control group.  The findings of the study indicate that THS shows positive correlation with total cholesterol, LDL cholesterol and triglyceride (r = 0.025, p = 0.865, r = 0.258, p = 0.071 and r = 0.078, p = 0.589 respectively) and HDL cholesterol exhibiting a negative correlation (r = -0.055, p = 0.704). These results confirm that thyroid dysfunction is common, and may be associated with adverse health outcomes.
J. Dhaka National Med. Coll. Hos. 2013; 19 (02): 4-8
Using Microsoft Copilot in higher education and research
Authors: Viacheslav Osadchyi
Published: November 2024

The tutorial contains theoretical material on artificial intelligence-based chats, including Microsoft Copilot Chat. The authors provide a description of the Microsoft Copilot Chat interface, how to use it, and its capabilities. The main contribution is a large number of examples of prompts for various functions performed by teachers in the course of their professional activities, namely: assessment, communication, lesson planning, professional development, research, etc. The manual is addressed to researchers, academic staff, graduate students, students of higher education institutions, a wide range of educational and scientific communities, workers with young people, and anyone interested in the use of artificial intelligence in higher education and research.
A Survey on Attitude Towards Oocyte Cryopreservation Among Female Academic Staff in Universities in Enugu State, Nigeria
Authors:   Department of Human Kinetics Physical Education, Faculty of Education, Enugu State University of Science and Technology (ESUT), Enugu, Nigeria, Iheanacho IL , Nnabueze UC ,   Department of Human Kinetics Physical Education, Faculty of Education, Enugu State University of Science and Technology (ESUT), Enugu, Nigeria, SO Nweze ,   Department of obstetrics and gynecology, Enugu State University of Science and Technology College of Medicine/ Teaching Hospital, Enugu, Nigeria
Published: November 2024

Career women in institutions of higher learning face the double challenges of career growth and development as well as productive reproductive life hence the need to regularly examine their dispositions towards reproductive health preservation technology during their career years. The study examined attitude towards oocyte cryopreservation among female academic staff in universities in Enugu State. Descriptive research design was adopted for the study. Three research questions in line with the specific purposes of the study guided the study. The population consisted of 398 female lecturers from seven universities in Enugu State. A total of 200 lecturers randomly sampled from six out of seven universities served as respondents. Multi-stage sampling procedure involving two stages of purposive and proportionate sampling techniques were used to sample the respondents. However, out of 200 sampled female lecturers only 171 of them consented and were used for the study. A self-made, structured and validated questionnaire was used as instrument for data collection. The instrument was personally administered and collected at a later date with the help of five research assistants while data analysis was carried out with mean and standard deviation. Findings showed that female lecturers in universities in Enugu State exhibited positive attitude towards oocyte cryopreservation, reasons for oocyte cryopreservation and procedures involve in oocyte cryopreservation (x̄ = 2.72; x̄= 2.73; x̄ = 2.83). It was concluded that the female lectures in universities in Enugu State exhibited positive attitude towards oocyte cryopreservation. The recommendation among others is that further sensitization is needed through conferences, seminars and workshops by all relevant agencies of health including Non-governmental organizations (NGOs) for career women whose fertility potentials are threatened while Enugu State Government should establish oocyte cryopreservation centres in the major cities and towns in the State to further motivate career women including female lecturers.
Late and Fortuitous Diagnosis of Two Cases of Uterine Malformations in Senegal and Review of The Literature
Authors:   Gynecological and Obstetrical Clinic, CHU Aristide Le Dantec, BP 3001, Avenue Pasteur, Dakar, Senegal, CISSE M , GASSAMA o ,   Gynecological and Obstetrical Clinic, CHU Aristide Le Dantec, BP 3001, Avenue Pasteur, Dakar, Senegal, SENE M ,   Gynecological and Obstetrical Clinic, CHU Aristide Le Dantec, BP 3001, Avenue Pasteur, Dakar, Senegal, DEM I ,   Gynecological and Obstetrical Clinic, CHU Aristide Le Dantec, BP 3001, Avenue Pasteur, Dakar, Senegal, DIOUF A ,   Gynecological and Obstetrical Clinic, CHU Aristide Le Dantec, BP 3001, Avenue Pasteur, Dakar, Senegal
Published: November 2024

The frequency of uterine malformations is difficult to assess. Their detection requires specific explorations (hysterosalpingography, MRI, hysteroscopy and laparoscopy). The bicornuate uterus is the best known of the uterine malformations and represents about half of the uterine malformations. They are also characterized by latency and clinical polymorphism. However, it is necessary to think about it in front of any accident of the pregnancy and any infertility of the couple. We report two cases of uterine malformations (Pseudo-unicorn uterus) discovered late and fortuitously intraoperatively
O papel dos moduladores inflamatórios na indução da Esclerose Hipocampal em pacientes com Epilepsia do Lobo Temporal
Authors: Damasceno Maria Izabella Silva , McGill Sara Maria Soares , Almeida Gustavo Davi Pereira de , Leão Clarissa Viana , Moura Raiane Morais de Assunção , Araújo Anna Beatriz Carvalho , Horta Wagner Gonçalves
Published: November 2024

A epilepsia do lobo temporal (ELT) é uma síndrome neurológica comum, caracterizada por convulsões refratárias, frequentemente associada à esclerose hipocampal (EH). Compreender os mecanismos inflamatórios na ELT é fundamental para desenvolver tratamentos mais eficazes, especialmente para casos que não respondem às terapias convencionais. Com o objetivo de investigar a relação entre neuroinflamação e ELT com EH, realizou-se uma revisão sistemática seguindo diretrizes PRISMA, com uma amostra final de 10 artigos de 2019 a 2024 disponíveis na Biblioteca Virtual em Saúde (BVS). Os resultados mostraram que a neuroinflamação, mediada por citocinas como IL-1β, IL-6 e a proteína HMGB1, exacerba as crises epilépticas. A ativação dos inflamassomas NLRP1 e NLRP3 e a resposta imune de microglia e astrócitos estão ligadas à degeneração neuronal no hipocampo. A neuroinflamação afeta a integridade do tecido hipocampal, neurogênese e plasticidade sináptica, levando a déficits cognitivos. Assim, a modulação das vias inflamatórias surge como possível estratégia terapêutica para reduzir crises e preservar a função cognitiva, mas mais estudos são necessários para otimizar o manejo clínico.
Percentual do consumo de medicamentos fitoterápicos durante e após pandemia entre os anos de 2020 e 2023 em uma farmácia escola na Cidade de Teresina, Estado do Piauí (PI), Brasil
Authors: Silva Alexsandra Alves , Lima Anne Gabriele Silva , Costa Débora Alencar Franco
Published: November 2024

A pesquisa examinou o impacto da pandemia de COVID-19 no consumo de medicamentos fitoterápicos na farmácia-escola de um Centro Universitário em Teresina/PI, entre os anos de 2020 a 2023. Com o isolamento social interferindo diretamente na saúde emocional e imunológica das pessoas, o estudo buscou entender como a pandemia influenciou a demanda por esses medicamentos. Por tanto, objetivo foi avaliar o percentual de consumo de fitoterápicos antes, durante e após a pandemia. A metodologia incluiu uma abordagem transversal, retrospectiva, qualitativa e quantitativa, com dados coletados manualmente em maio de 2024, considerando o consumo mensal e anual dos fitoterápicos. Os resultados mostram que em 2020, no auge da pandemia, houve um aumento nas saídas de fitoterápicos à medida que os meses passavam. Nos anos de 2021 e 2022, essa tendência de queda se consolidou, com uma redução média de 50% no consumo. No entanto, em 2023, após a pandemia, o consumo cresceu novamente, registando um aumento significativo de 70%. O estudo fornece insights valiosos sobre o comportamento de consumo de fitoterápicos no contexto da pandemia e pós-pandemia, contribuindo para pesquisas futuras e oferecendo subsídios importantes para profissionais da saúde e acadêmicos particularmente no uso de fitoterápicos em períodos de crises sanitárias.
Análise de processo de uma linha de produção de creme dental para redução de descarte de material
Authors: Costa Julia Bachini da , Oliveira Janaina da Costa Pereira Torres de , Lemos Washington de Macedo , Silva Julia de Oliveira e , Araujo Henrique Nilton Fernandes de , Landim Julia Cardoso
Published: November 2024

O objetivo desse trabalho é identificar uma das principais perdas produtivas de uma linha de produção de creme dental com a finalidade de otimizar o processo produtivo e com isso, reduzir a quantidade de resíduo industrial gerado. O trabalho utilizou diversas ferramentas de análise, como brainstorming, 5W2H e observação de tempos e movimentos, para identificar os principais problemas. A análise revelou que a linha de produção perdia uma quantidade significativa de tubos de creme dental ao final de cada ordem de produção, devido à ausência de um procedimento padrão e à falta de controle da produção. Para identificar as causas-raiz, foram empregados métodos como diagrama de Ishikawa e 5 porquês, o que identificou a produção excessiva como o principal fator contribuinte para o descarte dos materiais. O plano de ação, seguindo o ciclo PDCA (Planejar, Desenvolver, Checar e Agir), visou estabelecer procedimentos padronizados e criar um sistema de contagem e comunicação entre os equipamentos. Com a implementação dessas melhorias, houve uma redução de 78% na quantidade de material descartado e um aumento de 51 minutos na capacidade produtiva do operador. Este trabalho demonstra como a aplicação de metodologias e conceitos da Engenharia de Produção, como Análise de Processos, Gestão da Qualidade, Gerenciamento de Projetos, Controle de Produção.
Protagonismo Discente e Curricularização da Extensão: Um debate necessário
Authors: Trentin Daiane Toigo , Pessini Magali Inês , Ferreira Rosângela , Polesso Luiza Borges , Calabró Luciana
Published: November 2024

A inserção da extensão nos currículos dos cursos de graduação vem permeando os debates sobre a educação superior no Brasil. Esta prática integra atividades extensionistas nos currículos dos cursos de graduação, promovendo a interação entre a academia e a sociedade alavancando o protagonismo discente. Neste contexto, este artigo tem o objetivo de discutir o protagonismo discente no processo de curricularização da extensão nos Institutos Federais através da análise dos PPCs dos cursos designados. A investigação caracteriza-se como qualitativa-descritiva, sendo realizada através da análise documental. A análise dos dados baseou-se na Análise de Conteúdo e foi realizada com o auxílio do software ATLAS.ti. As unidades de registro codificadas foram: a) curricularização da extensão e, b) protagonismo discente. Após a análise dos textos selecionados, percebeu-se que grande parte dos excertos extraídos tratavam de aspectos normativos relacionados às citações da legislação existente, desconsiderando aspectos importantes, como a concepção de Extensão da instituição e, especialmente, a participação dos estudantes nessas atividades. Com relação ao objetivo proposto, observou-se que a participação estudantil é um tema distante da compreensão da prática da Extensão expressa nos PPCs, sendo necessário avançar nas discussões e propostas que visem ampliar o protagonismo discente no processo de curricularização da Extensão.
Analysis of adverse reactions related to the use of methylphenidate: An integrative review of the literature
Authors: Moura Rafael Barbosa de , Costa Ana Emilly Lima da , Sá Catharina Cavalcanti Ribeiro de , Andrade Cicera Lohanny Viana , Loiola Karollina Soares , Sousa Maria Carla Chaves de
Published: November 2024

Methylphenidate is a stimulant of the Central Nervous System (CNS) used worldwide in the treatment of Attention Deficit/Hyperactivity Disorder (ADHD), which acts mainly by blocking the dopamine transporter (DAT), inhibiting the reuptake of dopamine by SRIs, causing improvement in ADHD symptoms. When carrying out treatment with Methylphenidate, potential adverse effects may arise. This study aimed to analyze the main adverse reactions cited in other literature on Methylphenidate, to evaluate its safety. This is an Integrative Literature Review Study, carried out from the selection of articles that covered the proposed objectives, with results that show the authors' assessments of adverse reactions related to the use of Methylphenidate. Among the effects observed, psychotic effects, speech changes, tics, cardiovascular risks, and growth retardation are associated with the use of Methylphenidate. From this, it is concluded that effects such as vascular risks, growth retardation, mania, changes in speech, and others related to psychotic effects may be present in patients undergoing treatment with Methylphenidate, impacting the quality of life of those who use it.
Análise dos impactos causados pela Dengue na Saúde Pública brasileira: Uma revisão da literatura
Authors: Martini Isadora , Mattos Maria Izabel Pereira de
Published: November 2024

Introdução: A dengue é uma arbovirose causada pelos sorotipos DENV-1, DENV-2, DENV-3 e DENV-4, que se dissemina principalmente por meio da picada do mosquito Aedes aegypti. Esta doença representa um desafio significativo à saúde pública, com cerca de 390 milhões de infecções anuais em todo o mundo, das quais aproximadamente 20 mil resultam em óbitos, evidenciando uma maior vulnerabilidade na população jovem, que apresenta menor exposição prévia ao vírus. Objetivo: Evidenciar os impactos causados pela dengue na saúde pública brasileira entre 2023 e 2024. Metodologia: Revisão narrativa de literatura baseada em 10 artigos científicos publicados entre 2023 e 2024. Resultados e discussão: Entre 2023 e 2024, a dengue causou impactos significativos na saúde pública brasileira, refletindo um aumento considerável na incidência da doença e sobrecarga no sistema de saúde. O reconhecimento precoce dos sintomas é fundamental, assim como a implementação de protocolos que integrem a vacinação nas estratégias de prevenção. A resistência crescente do vetor Aedes aegypti às medidas tradicionais de controle exige novas abordagens que incluam biotecnologia e gestão ambiental. Além disso, a combinação de vacinação, conscientização comunitária e melhorias nas condições de saneamento é essencial para mitigar os impactos da dengue e melhorar a resposta à epidemia. Conclusão: A abordagem integrada e sustentável é crucial para enfrentar os desafios impostos pela dengue, garantindo a proteção da saúde pública e a redução da carga econômica relacionada à doença.