bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan E-Book Berbasis Model TaRL (Teaching at The Rigth Level) sebagai Bahan Ajar dalam Pembelajaran Literasi Dasar Membaca di Sekolah Dasar
Authors: Ahyar Ahyar , Fitriati Ita , Nurgufriani Anita , Syarifudin Syarifudin
Published: February 2024

The aim of this research is to determine the feasibility and effectiveness of E-Books based on the TaRL model as teaching materials in learning basic reading literacy at elementary school level. The Teaching at The Right Level (TaRL) model is a model used to improve a person's reading ability according to their reading ability level. TaRL has been empirically proven to be able to improve students' reading abilities. This research was designed using the Research & Development method, Design Based Research model. Data was obtained using questionnaire instruments, observations and interviews. Questionnaires are needed to validate media and materials followed by interviews. The results of this research are in the form of an E-Book product which contains basic reading literacy learning packages for each reading ability level group. The results of product validation tests by media experts show that this E-Book is valid with several notes. Meanwhile, the results of validation tests by material experts show that this E-Book is valid, provided that its contextual value is increased by local stories typical of the local area. This e-book is also effective based on limited response from those who use it on a small scale. Thus, E-Books with the TaRL model are declared very suitable and effective for use in learningAbstrakTujuan penelitian ini yakni untuk mengetahui kelayakan dan efektivitas E-Book berbasis model TaRL sebagai bahan ajar dalam pembelajaran literasi dasar membaca pada jenjang SD. Model Teaching at The Right Level (TaRL) merupakan model yang digunakan untuk meningkatkan kemampuan membaca seseorang sesuai tingkat kemampuan baca. TaRL terbukti secara empiris mampu meningkatkan kemampuan baca pebelajar. Penelitian ini didesain menggunakan metode Research & Development model Design Based Research. Data diperoleh dengan menggunakan instrumen kuisioner, observasi dan wawancara. Kuisioner diperlukan untuk validasi media maupun materi yang dilanjutkan dengan wawancara. Hasil penelitian ini berupa produk E-Book yang memuat paket pembelajaran literasi dasar membaca untuk masing-masing kelompok tingkat kemampuan membaca. Hasil uji validasi produk oleh ahli media menunjukkan bahwa E-Book ini valid dengan beberapa catatan. Sementara hasil uji validasi oleh ahli materi diketahui bahwa E-Book ini valid dengan catatan supaya nilai kontekstualnya bertambah dengan cerita lokal khas daerah setempat. E-Book ini juga efektif berdasarkan tanggapan terbatas dari yang memanfaatkan dalam skala kecil. Dengan demikian E-Book dengan model TaRL dinyatakan sangat layak dan efektif untuk digunakan dalam pembelajaran.
Cardiology Service of Kazakhstan Today: Acute Coronary Syndrome, Chronic Heart Failure, Atherosclerosis
Authors: Bekbossynova M. S. , Ivanova-Razumova T. V. , Dzhetybayeva S. K. , Oralbekova Z. O.
Published: February 2024

The article focuses on the prevalence of circulatory diseases, organization and implementation of new programs in the system of cardiological care services in the Republic of Kazakhstan. Currently, three key programs are functioning at the republican level: “Acute coronary syndrome”, “Chronic heart failure”, and “Atherosclerosis and dyslipoproteinemia”. The National Scientific Cardiac Surgery Center (Astana) is the coordinator of all these programs.
Possibilities of Using the National Electronic Data Syetstem in Assessing the Control of Arterial Hypertension at The Primary Health Care Level in the Kyrgyz Republic Using the Example of a Single Family Medicine Center
Authors: Polupanov A. G. , Arykova A. T. , Tolebaeva A. A. , Borubaev M. Ch. , Altymysheva A. T. , Dzhishambaev E. D. , Dzhamagulova A. S. , Abilova S. S. , Sooronbaev T. M.
Published: February 2024

Aim. To determine the capabilities of the National Electronic System for collecting quantitative data necessary to assess the quality of management and effectiveness of arterial hypertension (AH) control at the primary health care (PHC) level and to develop indicators and possibilities of their use for a standardized report on the quality of AH management and control at the PHC level in the Kyrgyz Republic.

Material and methods. Data from electronic outpatient records were processed for all registered patients of a pilot family medicine center (FMC) that was selected randomly. The registered patient group consisted of 91,226 people older than 18 years, including 37,740 men and 53,486 women. The data obtained during contact with a patient was entered by the family doctor into the electronic outpatient record and automatically forwarded to the center that collected and aggregated the data. To monitor AH control, 11 indicators were developed and evaluated. The indicators were divided into 3 groups: indicators for identifying AH, indicators for the quality of AH patient management, and indicators for the effectiveness of AH control.

Results. In total, 26,206 patients (7,933 men and 18,273 women) visited the FMC during a year, and blood pressure (BP) was measured in 71.4% of them. In 2022, 5,072 patients (5.6% of the registered group) visited the FMC for AH, including 1,539 men and 3,533 women (4.1 and 6.6% of the registered patient group, respectively; p<0.001). The proportion of patients with AH who, according to the clinical protocol, had their BP measured 2 times a year or more, was 81.4% and was slightly higher for women than for men (82.3% and 79.1%, respectively; p<0.01). 38.7% of AH patients received antihypertensive drugs. Lipid-lowering therapy was prescribed to 23.5% of AH patients. The proportion of AH patients taking acetylsalicylic acid was higher, 36.3% for the whole group, including 34.1% for men and 37.2% for women (p<0.05). The efficacy of AH treatment was 62.8%.

Conclusion. Any monitoring system has limitations for the amount of useful data that can be obtained ensuring their proper quality. Taking this into account, two major indicators are suggested to use for evaluating the effectiveness of AH control at the PHC level: 1) the number of AH patients who have achieved the BP goal; 2) the number of AH patients who visited a medical institution (health care facility) during a calendar year relative to the number of registered patients (AH detectability).
REFLECTIONS OF THE EGYPT-TÜRKİYE ALLIANCE ON THE ENERGY STRUGGLE AND POSSIBLE DEVELOPMENTS
Authors: BARUN İlteriş Kaan , KAZANCI Baybarshan Ali
Published: February 2024

The Eastern Mediterranean is one of the important regions in the international political arena. Considering the unexploited energy resources in the world, the Eastern Mediterranean basin has turned into a polarisation area of regional and global powers in the 21st century. With the polarisation in the basin, countries determine strategies through possible energy policies in the future. In addition, the political developments in the Eastern Mediterranean region and the strategies of Türkiye and Egypt to become energy supply centres constitute the field of investigation of this study. In this manner, it is aimed to make a qualitative comparative analysis of the energy struggle between Egypt and Türkiye. Therefore, seeking new ways out in the Egypt-Türkiye dilemma and determining the possible equations of interest in the future seems to be the most appropriate option to create the optimum benefit with the Win-Win strategy. In this context, it is understood that the Eastern Mediterranean energy struggle has a critical importance in Egypt-Türkiye relations and that the energy dilemma will be resolved through bilateral and multilateral cooperation.
The Impact of International Cooperation and Logistics Networks on CO2 Emission Reduction
Authors:   Korean Academy Of International Commerce, Inc., Song Min-Ju
Published: February 2024

Purpose: This study analyzes the causal relationships between CO2 emissions and ODA, logistics, renewable energy, economic growth, and industrialization.
Research design, data, and methodology: From 2006 to 2019, panel data related to CO2 emissions, ODA, logistics networks, renewable energy, economic growth, and industrialization were collected from a total of 84 countries. To analyze this model, panel unit root tests and panel co-integration tests were performed to confirm the stability and long-term causal relationships in the data. Subsequently, panel FMOLS and panel DOLS were used to identify variables affecting carbon dioxide, and pairwise panel Granger causality analysis was used to analyze causality between these variables.
Results: According to panel FMOLS and panel DOLS analysis, ODA and renewable energy reduce CO2 emissions, but economic growth increases CO2 emissions.
Conclusions: As a result of panel FMOLS and panel DOLS analysis, economic growth was identified as a factor in increasing CO2 emissions, and international development cooperation and renewable energy were identified as factors in reducing CO2 emissions.
Increasing Road Safety in Latin America and the Caribbean: Lessons from Behavioral Economics
Authors: Ramírez Indhira , Scartascini Carlos
Published: February 2024

Road crashes are a significant public health issue in Latin America and the Caribbean, resulting in a staggering toll of approximately 110,000 fatalities and over 5 million injuries annually. These tragedies have far-reaching economic implications, costing Latin America and the Caribbean between 3 and 5 percent of its gross domestic product. A great many road crashes can be attributed to a variety of unsafe behaviors, such as distracted driving, speeding, and impairment from alcohol or drugs. Through an understanding of cognitive and social factors that influence such behaviors, behavioral sciences offer valuable insights for developing effective interventions and strategies to promote road safety. This report focuses on the behavioral and cognitive biases that make accidents so common in our region, on initiatives implemented around the world using behavioral insights that could be beneficial to the region, and on the behavioral interventions that have been implemented in Latin America and the Caribbean to increase road safety.
My “Philosophical Generation”
Authors: Mikhailovsky A.V.
Published: February 2024

The article examines the phenomenon of generation, self-understanding / self-recognition in a generation from the standpoint of hermeneutical philosophy. The first part is a reproduction of the author's 1999 essay. It notes that 1) in the testimonies of individual representatives of the generation, mediation of the individual and the universal is carried out; 2) the identity of the generation is understood through a relationship with another; 3) for self-recognition in the generation, the “pre-reflexive” level is important, which precedes the division into intellectual and sensual. The second part contains a description of events, meetings with people, reading experiences and experiences of a representative of a generation whose intellectual formation took place mainly in the last decade of the 20th century.
Report of the 28th International Congress of Psychology in Beijing, China
Authors: Ogińska-Bulik Nina
Published: February 2024

28 Międzynarodowy Kongres Psychologii odbył się w Pekinie, w Chinach w dniach 8–13 sierpnia 2004 r. Kongres ten odbywał się pod auspicjami Międzynarodowej Unii Nauk Psychologicznych. Siedzibą było nowoczesne Centrum Kongresowe mieszczące się w azjatyckiej wiosce olimpijskiej, niedaleko Starego Miasta. Kongres zgromadził blisko 5000 reprezentantów. Odbyło się 227 zaproszonych sympozjów, ponad 300 sesji tematycznych i blisko 2600 aktywnych sesji posterowych. Polskę reprezentowało ponad 30 uczestników, w tym dwoje z Instytutu Psychologii Uniwersytetu Łódzkiego.
Mujeres de ánimo viril Estereotipos y roles de género en la conquista de América S. XVI
Authors: Perez Miguel ‪Liliana
Published: February 2024

El texto indaga por la manera en que determinadas actuaciones excepcionales llevadas a cabo por mujeres en el ámbito militar, durante la conquista de América en el siglo xvi fueron recogidas, interpretadas y relatadas, tanto por testigos de las mismas como por los cronistas, en función de los arquetipos y estereotipos de género estructurados/conformados a partir de convenciones sociales religiosas, morales o culturales, entre otras, vigentes en ese periodo. Para ello se analizarán algunos casos paradigmáticos del más temprano virreinato peruano. Todo ello se hará desde una perspectiva de género que posibilite analizar aspectos como los modelos femeninos trasladados al Nuevo Mundo, así como la consideración hacia la actuación de algunas mujeres en los territorios de frontera, donde diversos factores posibilitaron e, incluso, demandaron roles muy alejados de los normativos en la sociedad de la Edad Moderna.
Laporan Kasus:Urolithiasis dan Infeksi Bakteri Penyebab Penyakit Saluran Perkencingan Bagian Bawah pada Kucing Jantan Mixbreed
Authors: Apriliana Kadek Soma , Jayanti Putu Devi , Suartha I Nyoman
Published: February 2024

Seekor kucing persia mix British shorthair berjenis kelamin jantan berumur 7 tahun dengan berat badan 4,75 kg, dibawa ke Rumah Sakit Hewan Pendidikan Universitas Udayana dengan keluhan dysuria, hematuria, nafsu makan dan minum menurun. Pemeriksaan klinis dan fisik menunjukkan kucing kasus tampak lemas, dehidrasi dan mengalami distensi pada abdomen. Pada pemeriksaan ultrasonografi menunjukkan vesika urinaria penuh berisi urin karena retensi urin. Hasil pemeriksaan hematologi menunjukkan bahwa kucing mengalami leukositosis, limfositosis, MCH dan MCHC turun. Pemeriksaan kimia urin menunjukkan pH 8,0 dan tidak normal pada leukosit, nitrit, protein, dan eritrosit. Pada pemeriksaan sedimentasi urin ditemukan adanya kristal struvit, serta kultur urin ditemukan adanya bakteri Escheria coli dan Staphylococcus sp. Berdasarkan anamnesis, hasil pemeriksaan klinis, dan pemeriksaan penunjang, kucing kasus didiagnosis mengalami urolithiasis dan infeksi bakteri yang menyebakan Feline Lower Urinary Tract Disease (FLUTD) dengan prognosis fausta. Penanganan dilakukan dengan pemberian terapi cairan Ringer Lactate, pemasangan cateter urine, injeksi antibiotik cefotaxim, antiinflamasi dexamethasone, dan vitamin K. Obat oral yang diberikan yaitu antibiotik cefadroxil, antiinflamasi dexamethasone, obat herbal yang mengandung ekstraks kejibeling dan suplement yang mengandung zat besi, dan pakan urinary care. Satu minggu pasca terapi kucing dalam kondisi baik, urinasi lancar dan tidak adanya indikasi rasa sakit saat urinasi dan hasil pemeriksaan organoleptik, sedmentasi dan kimia urin tidak adanya keabnormalan.
Laporan Kasus: Ehrlichiosis pada Anjing Alaskan Malamut di Denpasar, Bali
Authors: Ginting Regina Bonifasia Beru , Jayanti Putu Devi , Batan I Wayan
Published: February 2024

Ehrlichiosis merupakan penyakit penting pada anjing yang disebabkan oleh bakteri intraseluler Gram negatif dari genus Ehrlichia yang termasuk dalam famili Anaplasmataceae. Hewan kasus anjing bernama Zena, jenis kelamin betina, ras alaskan malamute, memiliki warna rambut putih dan hitam berumur empat tahun dengan bobot badan 38,5 kg. Anjing dipelihara dengan cara dilepaskan di pekarangan rumah. Zena dibawa ke Anom Vet Clinic dengan keluhan lemas, penurunan nafsu makan dan minum selama dua hari serta anjing mengalami muntah lima kali sebelum dibawa ke klinik. Hasil pemeriksaan klinis anjing kasus terlihat lemas namun masih responsif, mukosa mulut merah muda pucat serta turgor kulit sedikit menurun. Teramati di bagian lateral kanan abdomen terdapat spot dermatitis. Saat observasi ditemukan caplak Rhipicephalus pada kulit dan anjing mengalami muntah cairan kuning. Hasil pemeriksaan penunjang berupa radiografi/X-ray dan ultrasonografi/USG regio abdomen tidak ditemukan kelainan yang berarti. Hasil pemeriksaan hematologi lengkap menunjukkan anjing kasus mengalami trombositopenia dan limfositopenia. Hasil pemeriksaan test kit menunjukkan hasil positif mengandung antibodi Ehrlichia canis. Berdasarkan anamnesis, tanda klinis, hasil pemeriksaan hematologi, dan pemeriksaan menggunakan test kit, anjing kasus didiagnosis menderita ehrlichiosis dengan prognosis fausta. Penanganan yang diberikan pada anjing kasus yaitu berupa terapi cairan dengan Ringer Laktat, doksisiklin selama 10 hari, dexamethasone selama lima hari, cimetidine selama lima hari dan Fu Fang Ejiao Jiang® 1 botol selama 10 hari. Penanganan hewan kasus menunjukan hasil yang baik secara klinis, dengan tidak terjadinya muntah dan nafsu makan sudah membaik setelah lima hari pengobatan. Pada hari ke-10, hewan kasus sudah membaik secara klinis dengan keadaan turgor kulit membaik, mukosa mulut berwarna merah muda, dan diperbolehkan pulang.
A percepção de um mestre sobre a arte da capoeira e seu impacto como ferramenta pedagógica para o enfrentamento de preconceitos
Authors: Cardoso José Tadeu Carneiro , Pasqua Livia de Paula Machado
Published: February 2024

Introdução: Ao longo de 50 anos de ensino, Mestre Camisa realizou viagens por diferentes países a fim de difundir a manifestação cultural Capoeira, tendo vivenciado diversas situações de ensino-aprendizagem, com pessoas de diferentes faixas etárias, gêneros e classes sociais. Objetivo: descrever a experiência de um mestre de Capoeira, principalmente no que tange aos preconceitos ainda existentes em sua área, a fim de colaborar para a construção de alternativas pedagógicas para o combate a discriminações e intolerâncias. Metodologia: Trata-se de um estudo de cunho descritivo-exploratório, com técnica de entrevista estruturada, interpretada e analisada por meio categorias estabelecidas a priori. Resultados e discussão: Foram discutidas as temáticas relacionadas a homofobia, racismo, machismo, xenofobia, adultocentrismo, capacitismo e intolerância religiosa na Capoeira. Entretanto, nesse relato, especificamente, foram evidenciadas as categorias relacionadas à intolerância religiosa, ao machismo e à formação em Capoeira. Em relação à intolerância religiosa realizou comparações com outras manifestações brasileiras de matrizes africanas que são confundidas com religiões e ressaltou o papel da valorização do componente histórico no ensino para o combate ao preconceito. Sobre as mulheres na Capoeira, mencionou o aumento da presença das mulheres nessa arte, a contribuição para seu desenvolvimento e a reivindicação para um olhar mais inclusivo. Em relação à formação, relatou sobre estratégias pedagógicas desenvolvidas em seu grupo. Considerações Finais: Espera-se que essa entrevista possa contribuir para pensar o enfrentamento a preconceitos e impacte no aproveitamento e desenvolvimento da Capoeira e seus aspectos pedagógicos em sua própria área e outras afins.
Azoximer bromide and hydroxyapatite: promising immune adjuvants in cancer
Authors: Rossi Jean-François , Frayssinet Patrick , Matciyak Maksim , Tupitsyn Nikolai
Published: February 2024

Immune adjuvants are immune modulators that have been developed in the context of infectious vaccinations. There is currently a growing interest in immune adjuvants due to the development of immunotherapy against cancers. Immune adjuvant mechanisms of action are focused on the initiation and amplification of the inflammatory response leading to the innate immune response, followed by the adaptive immune response. The main activity lies in the support of antigen presentation and the maturation and functions of dendritic cells. Most immune adjuvants are associated with a vaccine or incorporated into the new generation of mRNA vaccines. Few immune adjuvants are used as drugs. Hydroxyapatite (HA) ceramics and azoximer bromide (AZB) are overlooked molecules that were used in early clinical trials, which demonstrated clinical efficacy and excellent tolerance profiles. HA combined in an autologous vaccine was previously developed in the veterinary field for use in canine spontaneous lymphomas. AZB, an original immune modulator derived from a class of heterochain aliphatic polyamines that is licensed in Russia, the Commonwealth of Independent States, and Slovakia for infectious and inflammatory diseases, is and now being developed for use in cancer with promising results. These two immune adjuvants can be combined in various immunotherapy strategies.
Chemotherapy-free radiotherapy combined with immune checkpoint inhibitors: a new regimen for locally advanced non-small cell lung cancer?
Authors: Ma Lin , Deng Liufu , Peng Jianfeng , Yu Jinming , Meng Xiangjiao
Published: February 2024

Maintenance immunotherapy after concurrent chemoradiotherapy remains the standard therapeutic approach in patients with unresectable locally advanced non-small cell lung cancer (LA-NSCLC). The efficacy of pembrolizumab without chemotherapy in stage IV NSCLC has incited interest in similar approaches for LA-NSCLC. Several recent investigations involving the synergistic potential of immunotherapy combined with radiotherapy (iRT) have generated encouraging results. This review discusses the existing studies and prospective directions of chemotherapy-free iRT strategies in unresectable LA-NSCLC. Although the initial findings of chemotherapy-free iRT strategies have shown promising efficacy, we must consider the methodologic limitations of current studies and the myriad of challenges that accompany the implementation of chemotherapy-free iRT. These challenges include determining the optimal dose and fractionation, precise target volume delineation, and identification of additional suitable patient cohorts. Furthermore, the feasibility of chemotherapy-free iRT as a novel treatment modality for select patients with LA-NSCLC is contingent upon validation through randomized phase III trials.
Modular Design of Multistable Pneumatic Structures from a Flat Pattern of Air Pouches
Authors: Zhang Yiwei , Tendo Tomoya , Tachi Tomohiro
Published: February 2024

We introduce a novel family of structures that can be inflated from a plane to form a three-dimensional surface using articulated straight pouches with inextensible membranes. Specifically, we propose a modular design using a quadrangle surrounded by four slender pouches, whose inflation
causes the surface to form a saddle shape. Then we show a fabrication method using heated nylon films with heat adhesives separated by paper mask patterns inside. We first show a geometric model to explain and predict the out-of-plane deformation and the bi-stability effect inherited in this
structure. Through a geometric analysis and an elastic simulation of a pouch, we show that lowering the width-length ratio of pouches reduces the imperfection of shapes. We further propose a method for controlling the height of saddles using concentric patterns. We then extend structural modules
into multiple-grid systems and identify the multistable behaviors of the overall structure.
Book. Reading. Media is a Space of Knowledge Related to a Person Who Reads, Writes and Media
Authors: Lizunova I. V. , Moreva O. V.
Published: February 2024

The purpose of the article is to introduce the editorial policy, mission and plans of the new journal, established by the State Public Scientific and Technological Library of the Siberian Branch of Russian Academy of Sciences (SPSTL SB RAS) in 2023. The Book. Reading. Media is called to become a platform for representatives of various scientific disciplines who study books, readers and media in the past and present. The article contains the opinions of the members of the editorial board, leading Russian and foreign experts in the field of book studies, library science, reader studies, media studies, cultural studies, etc. All of them are confident in the relevance of the new journal’s subject and express their hopes for its successful development and relevance among professionals.
The Effect of R&D Investment of Chinese Companies on Business Innovation Performance
Authors: Jiang EnLu , Li ZhengGuang
Published: February 2024

This study aims to analyse whether Chinese companies' R&D investment affects management innovation performance. Also, this dissertation defines management innovation as diversification strategies such as technology and industry diversification and analyzes the impact of these diversification strategies. In particular, this paper analyzes whether R&D investment leads to technology and industry diversification and whether technology diversification creates a mediating effect in the process of R&D investment leading to industry diversification. The analysis results can be summarized as follows: First, R&D investment showed a significant positive relationship with industry diversification. Second, R&D investment shows a significantly positive relationship with technology diversification. Third, technology and industry diversification showed a positive relationship. Fourth, this study examined the mediating role of technology diversification, and it was confirmed that technology diversification plays a mediating role in the effect of R&D investment on industry diversification. R&D investment and business innovation play a key role in the sustainable development of enterprises, and the findings of this paper have important reference value for enterprises' R&D investment decision-making. The results of this study provide the following implications that Chinese companies improve business innovation performance by increasing their R&D investment, promoting innovative R&D, and improving technology diversification and industry diversification strategies.
Operative hysteroscopy. Opportunities and perspectives in complicated pregnancy
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Davydov A.I. , Gasratova A.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Lebedev V.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Pashkov V.M. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Shakhlamova M.N. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Bakhtiyarov K.R. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: February 2024

Today, operative hysteroscopy is widely used to treat not only gynecological diseases, but also pregnancy-related complications such as cervical pregnancy, cesarean scar pregnancy, interstitial pregnancy, and placenta accreta spectrum. The use of operative hysteroscopy in all the above-mentioned pathologies undoubtedly requires strict compliance with several conditions that determine the scope of hysteroscopy. If these conditions are met, operative hysteroscopy is the treatment of choice for cervical pregnancy, cesarean scar pregnancy, less frequently for interstitial pregnancy and placenta accreta spectrum diagnosed after spontaneous labor. Key words: operative hysteroscopy, hysteroresectoscopy, cervical pregnancy, cesarean scar pregnancy, interstitial pregnancy, placenta accreta spectrum
Dyslipidemia of pregnancy in normal and complicated pregnancies. Possibilities of pharmacotherapy
Authors:   Smolensk Regional Clinical Hospital, Smolensk, Russian Federation, Volynets L.I. , Konyshko N.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Konyshko G.S. ,   Smolensk State Medical University, Smolensk, Russian Federation, Kapustina E.E. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: February 2024

Pathological changes in lipid metabolism are associated with morbidity and mortality not only during gestation but also later in life in mothers and their offspring. These circumstances actualize the study of dyslipidemia and its correction during pregnancy. This article presents an analysis of clinical, randomized and cohort studies, systematic reviews and meta-analyses, clinical cases and guidelines in available full-text publications from PubMed, Elsevier, Scopus, Google Scholar, and E-library for the period 1970–2023. Results. Normal pregnancy is characterized by increasing lipid production that contributes to healthy fetal development. The presence of atherogenic dyslipidemia before pregnancy and during early weeks is marked by high levels of triglycerides and low-density lipoproteins and low levels of high-density lipoproteins, which increases the risk of pathology and adverse pregnancy outcomes, fetal macrosomia, and cardiovascular disease later in life in mothers and their offspring. Pregnancy complications (pre-eclampsia, gestational hypertension, and diabetes) and maternal obesity may exacerbate adverse changes in lipid profile and clinical outcomes. Current medications used to treat components of the metabolic syndrome include vitamin D (if deficient), probiotics, and omega-3 fatty acids. Fibrates, bile acid sequestrants, metformin and orlistat may be prescribed in certain cases if the benefit of their use exceeds the likelihood of undesirable effects in high-risk pregnant women or in the presence of pregnancy abnormalities. Key words: pregnant women, lipid metabolism, cholesterol, obesity, pre-eclampsia, arterial hypertension, hypolipidemic agents
The republic of Buryatia: modern tendencies in population morbidity and mortality from circulatory system diseases.
Authors:   “The N. A. Semashko National Research Institute of Public Health” of the Ministry of Science and Higher Education of the Russian Education, Karpova O. B. , Nechaev V. S. ,   “The N. A. Semashko National Research Institute of Public Health” of the Ministry of Science and Higher Education of the Russian Education, Zagoruychenko A. A. ,   “The N. A. Semashko National Research Institute of Public Health” of the Ministry of Science and Higher Education of the Russian Education
Published: February 2024

In the Russian Federation, as in many European countries, for many years the system of circulatory diseases has been a significant threat to public health and the medical and demographic situation, which supports the increase in mortality from these causes in many regions. The purpose of the study is to study current trends in morbidity and mortality of the population in class “IX. Diseases of the circulatory system» in comparison with the planned target indicators of the regional program and identify priority areas for improving strategic health care planning at the regional level (Republic of Buryatia). Material and methods. The information base consisted of various scientific publications and regulatory documents on strategic management in the territory of the Republic of Buryatia and the Far Eastern Federal District. The analysis was also carried out using statistical data from the database of Rosstat and the Ministry of Health of Russia and on the basis of content analysis of draft strategies that were available on the official websites of government bodies, constituent entities of the Russian Federation, etc. The analysis methodology included the method of studying and generalizing experience, the mathematical-statistical method and content analysis. Results. Based on available statistical information, the publication analyzes current trends in morbidity and mortality from diseases of the circulatory system in the Republic of Buryatia for 2017–2021. and compared with the target indicators of the regional program adopted within the framework of the federal project “Combating Cardiovascular Diseases”. Conclusions. The results of the analysis can be used in strategic planning for the development of territorial healthcare in the Russian Federation and in the development of strategies, concepts and programs for protecting public health.
Features of natural population movement in the region of the Central federal district. Forecast indicators.
Authors:   N. A. Semashko National Research Institute of Public Health, Zhelezova P. V. , Mingazova E. N. ,   N. A. Semashko National Research Institute of Public Health,   Kazan State Medical University
Published: February 2024

The analysis made it possible to highlight the main features of the natural population movement in the Kostroma region as a region of the Central Federal District: depopulation of the population is observed – a long-term natural population decline, while the number of deaths significantly exceeds the number of births; natural decline was noted among both the urban and rural population of the region. Using predictive models without taking into account changes in the demographic situation during COVID‑19, it was calculated that in the Kostroma region we can expect an increase in the number of births per 1000 people from 8.5 in 2020 to 9.9 in 2024 (optimistic script); reduction to 8.9 in 2024 (according to the pessimistic scenario); growth to 9.4 in 2024 (according to the average forecast). In addition, a decrease in the number of deaths per 1000 population is calculated from 16.7 in 2020 to 11.7 in 2024 (according to the optimistic scenario); reduction to 13.0 in 2024 (according to the pessimistic scenario); to 12.3 in 2024 (according to the average forecast).
Ecological modeling of microbial community composition under variable temperatures
Authors: Gonzalez Logan , Baker Christopher , Doherty Stacey , Barbato Robyn
Published: February 2024

Soil microorganisms interact with one another within soil pores and respond to external conditions such as temperature. Data on microbial community composition and potential function are commonly generated in studies of soils. However, these data do not provide direct insight into the drivers of community composition and can be difficult to interpret outside the context of ecological theory. In this study, we explore the effect of abiotic environmental variation on microbial species diversity. Using a modified version of the Lotka-Volterra Competition Model with temperature-dependent growth rates, we show that environmentally relevant temperature variability may expand the set of temperature-tolerance phenotype pairs that can coexist as two-species communities compared to constant temperatures. These results highlight a potential role of temperature variation in influencing microbial diversity. This in turn suggests a need to incorporate temperature into predictive models of microbial communities in soil and other environments. We recommend future work to parameterize the model applied in this study with empirical data from environments of interest, and to validate the model predictions using field observations and experimental manipulations.
Covid-19 and Exposed to Vulnerabilities in The Creative Economy: Get Up Or Give Up
Authors: Santosa Agus , Rulinawaty Rulinawaty
Published: February 2024

Academic literature extensively acknowledges the fragile character of creative and cultural activity. However, it has frequently been invisible to policymakers and decision-makers. As soon as Covid-19 began affecting local and national economies worldwide, numerous business and policy organizations hastened to research the impact of Covid-19 on the creative and cultural industries (CCIs) and their workforce. The report provides insight into these organizations' primary issues through a meta-analysis of the current survey and research programs in the United Kingdom. The findings shed light on prevalent concerns regarding visible and unseen challenges that require attention in this area. The study continues by debating if Covid-19 represents a watershed event for the sector or merely reveals the unsustainable cost of creative and cultural activity.
Analysis Factors Affecting Customer Loyalty of Indihome Provider During The Covid-19 Pandemic In Surakarta
Authors: Mutikasari Aini Dwi , Susila Ihwan
Published: February 2024

The purpose of this study is to investigate how customers feel about IndiHome's service quality, brand perception, and trust in light of the current Covid-19 outbreak in Surakarta. Participants were people who used the IndiHome service in the Surakarta region. For this study, we employed a sampling strategy that was both statistically and practically effective. In Surakarta, where IndiHome is popular, an online questionnaire was administered to 164 customers. For the quantitative study, we used SPSS version 25's multiple regression function. According to the results, trust plays a significantly lower role in determining customer loyalty than do service quality and brand image. This paper gives scholars and businesspeople in Surakarta insights on the loyalty of IndiHome customers to their service provider.
Outcome-Based Education Scoring System Utilizing Modular Object-Oriented Dynamic Learning Environment
Authors: Ni'mah Ana Tsalitsatun , Solihin Firdaus , Sari Ita Uliyah
Published: February 2024

The dynamic nature of education necessitates inventive approaches to assessment and evaluation. This study concentrates on formulating a Scoring System aligned with Outcome-Based Education (OBE) principles, utilizing the Modular Object-Oriented Dynamic Learning Environment (MOODLE) platform. OBE prioritizes showcasing specific learning outcomes, cultivating a student-centric approach. The proposed system seeks to improve assessments through a flexible framework accommodating diverse learning objectives, employing a modular and object-oriented design. Integration with MOODLE, a widely-used e-learning platform, explores seamless implementation and user-friendly interaction. The Scoring System aids educators in efficiently evaluating student performance against predefined outcomes, fostering transparency and accountability.Key features include customizable assessments, progress tracking, and timely feedback. The study also examines the system's impact on student engagement, motivation, and overall learning outcomes, contributing valuable insights to innovative assessment methodologies in contemporary education. In conclusion, the research introduces a Scoring System harmonizing OBE principles with MOODLE's flexibility, benefiting educators, students, and institutions. The study's outcomes provide valuable implications for educators and technologists aiming to enhance assessments in the evolving education landscape.
Implikasi Program Adiwiyata terhadap Karakter Peduli Lingkungan di Sekolah Dasar
Authors: Sari Kumila , Sugiyono  , Suryatin Suryatin
Published: February 2024

Penelitian ini bertujuan untuk mendeskripsikan pelaksanaan program adiwiyata dan implikasi pelaksanaan program adiwiyata terhadap karakter peduli lingkungan di Sekolah Dasar Negeri 2 Purwoasri. Jenis penelitian ini adalah deskriptif kualitatif. Subjek penelitian ini adalah kelas V. Objek penelitian adalah pelaksanaan program adiwiyata dan karakter peduli lingkungan. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dokumentasi dan angket. Teknik pemeriksaan keabsahan data menggunakan triangulasi sumber dan teknik. Teknik analisis data yang digunakan reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa: (1) pelaksanaan program adiwiyata di Sekolah Dasar Negeri 2 Purwoasri memiliki kategori sangat baik dengan skor sebesar 4,14  dan terlaksana sesuai standar program adiwiyata dari pemerintah, (2) implikasi program adiwiyata terhadap karakter peduli lingkungan siswa di Sekolah Dasar Negeri 2 Purwoasri pada kategori sangat baik dengan persentase sebesar 53%  dan kategori baik dengan persentase 47%.
Plan de negocios para la implementación de un spa de mascotas a domicilio
Authors:   , Alarcon Vilchez Marco Antonio , Felipe Espinoza Jessica Karina , Chumpitaz Cuya Veronica Milagros , De Almeida Serna Ana Laura , Salazar Huaman Carlos Augusto
Published: February 2024

Nuestro spa para mascotas a domicilio Pampers Pets es un proyecto innovador que busca brindar servicios de baño de alta calidad y comodidad a los dueños de mascotas en la comodidad de sus hogares. Nos enfocamos en proporcionar una experiencia de spa relajante y segura para las mascotas, mejorando su bienestar y cuidado general. Nuestro enfoque principal es ofrecer servicios de baño personalizados y convenientes para perros. Nuestro equipo altamente capacitado y amante de los animales se desplaza a los hogares de nuestros clientes con todas las herramientas y productos necesarios para brindar un servicio de spa de primera calidad. Además de los baños, ofrecemos una gama de servicios adicionales, como tratamientos de acondicionamiento del pelaje, masajes relajantes, limpieza de oídos y recorte de uñas. Cada uno de nuestros servicios se ajusta de manera personalizada a los requisitos particulares de cada mascota, utilizando productos de alta calidad y técnicas seguras. Nuestro modelo de negocio basado en el baño a domicilio ofrece comodidad y conveniencia para los dueños de mascotas ocupadas, eliminando la necesidad de ocultar un spa físico. Nos diferenciamos de la competencia al brindar una atención personalizada y de calidad, centrándonos en el bienestar y la satisfacción tanto de las mascotas como de sus dueños. Nuestro mercado objetivo incluye a dueños de mascotas que valoran el cuidado y el bienestar de sus compañeros peludos. Estamos comprometidos con ofrecer un servicio de primer nivel al cliente, brindando una experiencia de spa única y memorable. Para promocionar nuestros servicios, utilizaremos una combinación de estrategias de marketing digital, como el desarrollo de un website que sea estético y optimizado para buscadores, la participación en plataformas sociales y la colaboración con influencers y veterinarios locales. También estableceremos alianzas estratégicas con tiendas…
Caracterización de la irregularidad en el tratamiento de tuberculosis sensible, en un Centro de Salud del Sur de Lima 2017-2020
Authors:   , Heredia Chirinos Ruth Noemi
Published: February 2024

Objetivo: Analizar las características de la irregularidad en el tratamiento de la tuberculosis sensible en un centro de salud del sur de Lima 2017-2020. Materiales y métodos: el estudio fue de enfoque cuantitativo, diseño no experimental, nivel descriptivo, retrospectivo de fuente secundaria. Se utilizó una ficha de recolección de datos, basada en la Norma Técnica de Salud para la Atención Integral de las personas afectadas por Tuberculosis. La población estaba constituida por 200 historias clínicas de pacientes diagnosticados con tuberculosis sensible, atendidos entre los años del 2017-2020, pertenecientes al Centro Materno Infantil José Carlos Mariátegui, el muestreo fue de conveniencia, para el proceso de datos se creó una base de datos en el programa Microsoft Excel. Resultados: De los 200 registros/ historias clínicas de pacientes con tuberculosis sensible solo 115 cumplieron con criterios de inclusión, el 62.61%, fue regular al tratamiento y el 37.39%, fue irregular, la edad promedio fue de 29 años, en su mayoría varones, y solteros, el 56,52% tenían secundaria completa, y el 55,65% no trabajaba. La duración media del tratamiento de tuberculosis fue de 7 meses, el 69,57% fue diagnosticado con tuberculosis pulmonar, también consumían alcohol y fumaban. Conclusión La frecuencia de irregularidad total al tratamiento de la tuberculosis sensible fue 37.39%, siendo más frecuente en la segunda fase del tratamiento (43.48%).
Nivel de conocimiento sobre salud oral de padres y su relación con hábitos de higiene oral de sus hijos de 8 a 10 años
Authors:   , Clavijo Valladares Alex Jair
Published: February 2024

Objetivo: Determinar la relación del nivel de conocimiento en salud oral de los padres de familia con los hábitos de higiene oral de sus hijos de 8 a 10 años. Material y métodos: Este estudio transversal se aplicó a una muestra de 200 padres (70% varones y 70% de 24-40 años) y sus respectivos hijos (52,5 varones; 44% de 8 años) de dos colegios privados de Lima en 2021. Dos cuestionarios fueron aplicados, uno de 20 ítems de conocimientos de salud oral dirigido a padres y otro de 4 ítems de higiene oral aplicado a sus hijos. El análisis estadística se trabajó con las pruebas de U de Mann-Whitney o Kruskal Wallis con un nivel de significancia de P<0,05. Resultados: La mayoría presentó un nivel regular en hábitos de higiene oral (59%) y de conocimientos de salud oral (53%). La edad del niño se relacionó a la frecuencia de cepillado diario (P=0,004) y los elementos de higiene oral (P=0,0024), mientras que el grado de instrucción de los padres se relacionó al nivel de conocimientos de salud oral (P=0,000). Los niveles más altos de conocimiento de los padres se asociaron a niveles más altos de higiene oral sobre frecuencia de cepillado dental semanal (P=0,012). Conclusión: Tanto la higiene oral como el nivel de conocimiento en salud oral resultaron regulares mostrando una relación positiva a mayor frecuencia de cepillado semanal.
Desarrollo de software de facturación electrónica para mejorar el proceso de emisión de comprobantes en la Empresa Construaprende S.A.C. 2021
Authors:   , Ilizarbe Tito Eduardo , Apaza Quispe Luis Angel
Published: February 2024

La tesis titulada “Desarrollo de software de facturación electrónica para mejorar el proceso de emisión de comprobantes en la empresa Construaprende S.A.C. 2021”, la cual hoy la emisión de los comprobantes es desde la plataforma de Sunat, esto hace que se vuelva engorroso y lento generando posibles errores humanos al consignar los datos. Este desarrollo ha tenido como principal objetivo implementar un sistema de facturación electrónica, debido a la necesidad y los inconvenientes de la facturación desde la plataforma web de Sunat. El desarrollo de este nuevo sistema tiene mejoras en cuanto al tiempo de emisión de comprobantes, menor cantidad de errores y sobre todo está cumpliendo con la normativa de Sunat. La población se considera el objeto de estudio a los comprobantes emitidos desde el 1 de diciembre del 2021 hasta la fecha de la empresa Construaprende S.A.C. La muestra es por conveniencia no probabilística y es aplicado a una cantidad de facturas emitidas en diciembre del 2021 y mayo del 2022. Se concluye que el desarrollo de software de facturación electrónica mejora el proceso de emisión de comprobantes de pago en la empresa Construaprende SAC 2021, bajo el diseño preexperimental se evidencia en los resultados obtenidos para la prueba T de Student diferencias favorables de puntaje entre el pretest y postest con una significancia de 0.000 que es menor a 0.05, finalmente para la Prueba U de Mann Whitney también diferencias favorables entre el pretest y postest con una significancia de 0.002 que es menor a 0.05.