bluuebunny/crossref_metadata_2025 huggingface dataset:
Зарядьелогия
Authors: Муравски Михал
Published: November 2018

Эта статья написана вместо введения в политическую эстетику парка «Зарядье». Примыкающий к Кремлю статусный проект стоимостью 300 млн долл., спроектированный архитекторами манхэттенского парка Хай-Лайн на руинах грандиозной гостиницы «Россия» брежневской эпохи и открытый Владимиром Путиным под звуки фанфар в сентябре 2017 г. парк «Зарядье» — флагманский проект мэрии Собянина, стирающей неугодное советское наследие и «дикий капитализм» мэрии Лужкова (1991–2010 гг.) из ткани города. Но «Зарядье», получившее прозвище «путинский рай», как пишут критики, также является главным примером того, что преображение Москвы больше похоже на представление, чем на реальность: косметическая ретушь «поверхности» города (и его центра), а не существенный ремонт ветхой социальной инфраструктуры (и периферии). Какова связь между представлением и сутью, симуляцией и реальностью, суперструктурами и инфраструктурой, государством и искусством внутри «путинского рая» и вокруг него? Как осуществляются, реализуются и раскрываются преемственности и разрывы — экономические, политические, эстетические — между социализмом и постсоциализмом, между эпохами Лужкова и Собянина?

Эта статья написана по итогам годовой полевой работы, проводимой в сотрудничестве со студентами Высшей школы урбанистики имени А.А. Высоковского. Мы изучаем инфраструктуру и суперструктуры Зарядья, представления и реалии через множество призм, среди которых: фундаментальные мифы, логика дара, бриколажи сложных тендерных процессов, патриотические спектакли, контроверсии звуковых ландшафтов, конкурирующие претензии на авторство, сталкивающиеся культы (не)личности. Кроме того, в духе «этнографического концептуализма» мы сознательно внедряем представление и спектакль в качестве метода исследования. В итоге наше исследование напрямую вылилось в содержание «Портала Зарядье»1 — выставки, которая проводилась в Государственном музее архитектуры имени А.В. Щусева с 25 июля по 12 августа 2018 г. и кураторами которой стали я и Дарья Кравчук2.

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1 См.: bit.ly/zbuklet

2 Перевод выполнен Екатериной Кондратьевой и Артемом Гитлюшкой.
«Саркофаг гостиницы “Россия”»
Authors: Чубукова Маргарита Андреевна
Published: November 2018

В эссе, посвященном парку «Зарядье», который был открыт осенью 2017 г., зафиксирован ряд наблюдений, сделанных в ходе работы одной из исследовательских групп, участвовавших в антропологическом семинаре Высшей школы урбанистики имени А.А. Высоковского НИУ ВШЭ «Московские метаморфозы?». Просуммированные высказывания экспертов и неискушенных горожан о новом столичном общественном пространстве позволяют сделать предварительные выводы о типологии и накапливаемой символической ценности «главного парка страны».
Мифология «Зарядья»
Authors: Волкова Дарья Викторовна
Published: November 2018

В статье описываются составляющие мифа о Новой России, представленного в парке «Зарядье». С помощью круглых столов, интервью, включенных наблюдений и анализа социальных сетей было выяснено, как парк описывает Россию с помощью несвязных исторических событий, фрагментов России и направленной в будущее бионической архитектуры. Такие контексты позволяют говорить о метамодернистских началах парка.
SUPPRESSION OF CELLULAR P53 PROMOTES CYTOTOXICITY OF ONCOLYTIC VECTOR AT THE MODELS OF HUMAN GLIOBLASTOMA
Authors: Ulasov I. V. , Kaverina N. V. , Baryshnikov A. Yu.
Published: November 2018

Glioblastoma multiforme resistance requires a new approach for glioma therapy. Protein p53 is one of the main cellular oncogene, overexpressed in 50% of brain tumor cases. Impact of p53 attenuation was evaluated in the presence of oncolytic adenovirus and temodar, which exhibit anti-glioma effect using in vitro glioma models. Using U87 human glioma cells we observed an additive effect between alkilated chemotherapeutic agent temodar and oncolytic adenovirus which results into p53 inhibition. It occurs that attenuation of p53 using PFTa inhibitor, significantly prolongs cell death type II - autophagy and, therefore improves effect mediated by autophagy induced agents. In conclusion, combination of PFTa and temodar might represent a powerful therapeutic combination which sensibilises glioma cells to the infection with oncolytic vector.
MOLECULAR MECHANISMS OF MULTIDRUG RESISTANCE OVERCOMING BY LIPOSOMAL ANTITUMOR DRUGS
Authors: Baryshnikova M. A. , Baryshnikov A. Yu. , Afanasieva D. A.
Published: November 2018

The liposomal antitumor drugs cell death induction mechanism has been analyzed in this work. Liposomal dosage forms of doxorubicin, cisplatin and aranosa overcome drug resistance. However, the mechanism of overcoming drug resistance by this drugs is different. Liposomal doxorubicin overcomes multidrug resistance by liposomes binding with the P-glycoprotein in 185 position of glycine. Liposomal cisplatin overcomes monoresistance by external apoptosis gene activation. The liposomal aranosa does not use CD95/Fas signaling pathway of apoptosis. Thus, liposomal drug action mechanism depends on the type of cells, and on the antitumor drug, that is enclosed in a liposome and can be individualized in each case.
ROLE OF ESTROGEN RECEPTOR BETA IN THE DEVELOPMENT AND TREATMENT OF BREAST CANCER
Authors: Rodionova M. V. , Vorotnikov I. K. , Rodionov V. V. , Chkhivadze N. V. , Dudko E. A. , Ryabchikov D. A. , Oshkina E. V. , Bogush T. A.
Published: November 2018

Estrogen receptors are one of the major targets in cancer cells, acting on which it is possible not only to control the processes of carcinogenesis, but also to inhibit tumor cells growth. Brilliant confirmation of this is the results of long-term application of the first targeted therapy - antiestrogen tamoxifen - in breast cancer patients with positive hormonal status of the tumor. Being discovered in the 90s, estrogen receptor beta enhanced the understanding of estrogen-mediated signaling pathway and receptor-related interactions. This review of the literature presents data on the history of the discovery, structure and functional activity of selective estrogen receptor beta, and the results of existing clinical trials which have shown the predictive role of this marker.
LIPOSOMAL PHOTOSENSITIZER AMIDOAMINCHLORINE FOR PHOTODYNAMIC THERAPY OF RAT SARCOMA М-1
Authors: Kaplan M. A. , Malygina A. I. , Ponomarev G. V. , Mikhailovskaya A. A. , Drozhzhina V. V. , Arkhipova L. M. , Osipchuk J. S.
Published: November 2018

Effectiveness of a new photosensitizer (PS) liposomal amidoaminchlorine for PDT was studied on a tumor model of rat sarcoma М-1. The research objective: to define parameters of PS minimum effective dose and laser irradiation to achieve complete regression of the tumor. Dynamics of PS accumulation in tumor and healthy tissue was studied to define the PDT time course and antitumor efficiency of different PS doses and various parameters of laser irradiation. The study results defined the optimum term for PDT and minimally effective PS dose and established the parameters for laser irradiation.
DEVELOPING A MODEL OF LIPOSOMAL FORMULATION OF A NEW NATIONAL ANALOGUE HYPOTHALAMIC HORMONE SOMATOSTATIN, WHICH HAS ANTI-TUMOR ACTIVITY
Authors: Sanarova E. V. , Lantsova A. V. , Zhang Xi , Dmitrieva M. V. , Polozkova A. P. , Orlova O. L. , Shprakh Z. S. , Kiseleva M. P. , Borisova L. M. , Smirnova Z. S. , Oborotova N. A.
Published: November 2018

At present, the hormone somatostatin analogues is increasing interest in connection with their activity against hormone-dependent tumors, which leads to the need to develop domestic drugs belonging to this group. In the laboratory of chemical synthesis Institute of experimental diagnostics and chemotherapy of FSBI «N.N. Blokhin RCRC» synthesized new domestic pentapeptide somatostatin analogue of hypothalamic hormone (AGGS). In preliminary studies of this substance demonstrated sufficiently high antitumor activity AGGS on transplanted solid tumors of mice. Due to the insolubility of the substance in the water as an alternative liposomal formulation proposed, allowing to increase the bioavailability of the drag due to the possibility of intravenous administration, increased therapeutic efficacy and reduce side effects, by improving the selectivity of action against tumor cells. During experiments on the development of the liposomal formulation AGGS pre-established model containing as essential components of the liposomal bilayer and egg lecithin PEG-2000-DSPE in a molar ratio 72/1 and as a ciyo- protectant - sucrose. In developing the technological parameters of the process of obtaining dosage form (LF) found that for an acceptable size derived phosphohpid vesicles needs about 7 cycles extrusion. The lack of stability of liposomal dispersion selected composition during storage has led to this problem by means of freeze-drying, which kept the physico-chemical parameters LF at the initial level. The efficacy of the model LF on transplantable tumors of mice - breast adenocarcinoma Ca-755, which was more than 60 % of ITG at a dose of 5 mg / kg and more than 80 % ITG with 20 mg / kg. The findings of biological experiments indicate the prospects for further research and improvement liposomal LF to produce high-performance domestic anticancer drag from the group of somatostatin analogues.
THE COMBINED METHOD OF EFFECT PHOTODYNAMIC THERAPY AND RADIAL THERAPY ON SARCOMA М-1 OF RATS
Authors: Kaplan M. A. , Malygina A. I. , Ponomarev G. V. , Mikhailovskaya A. A. , Drozhzhina V. V. , Arkhipova L. M. , Osipchuk J. S.
Published: November 2018

Antitumoral therapy of sarcoma M-l of rats is spent with use of the combined method of treatment (photodynamic therapy and radial therapy) at various sequences of its carrying out, at different time intervals and parametres of a laser irradiation. A photosensitinogen dose amidoaminchlorine and a gamma radiation dose were identical at all spent researches. The purpose: to study influence of all components of combined therapy and to define optimum conditions of its carrying out for achievement of significant antitumoral effect in comparison with monotherapy of each of them. As a result of researches intensifying of inhibiting effect is taped at complex therapy and optimum parametres of its carrying out are found.
THE PREPARATION FOR INTRAOPERATIVE VISUALIZATION OF «SENTINEL» LYMPH NODES
Authors: Pankratov A. A. , Andreeva T. N. , Yakubovskaya R. I. , Kaprin A. D. , Konarev A. A. , Yakunina T. V. , Lukyanets E. A.
Published: November 2018

We developed the original preparation Lymphotest on the basis of disulphoderivative of diaminotriphenylmet- anic dye, differing from Lymphazurin by positions if sulphogroups in benzene ring - N-[4-[[4-(diethylamino)phenyl] (2,5-disulfophenyl)methylene]-2,5-cyclohexadien-l-ylidene]-N-ethylethanaminium hydroxide, inner salt, sodium salt. The proposed compound practically does not differ by spectrum from Lymphazurin, but is much more accessible and highly lymphotropic. Lymphotest in the form of 1% aqueous solution is characterized by a high diagnostic efficiency when using direct color lymphography, low toxicity (imposed dose exceeded the anticipated maximum dose for a human in 50-1000 times) and has no locally-irritating effect when using subcutaneously.
Immunofluorescent analyses of tumor marker beta-III tubuilin expression in tumor and ajacent normal lung tissue derived from patients with non-small cell lung cancer
Authors: Mamichev I. A. , Bogush T. A. , Dudko E. A. , Ryabinina O. M. , Grishanina A. N. , Kirsanov V. E. , Polotsky B. E. , Davydov M. M.
Published: November 2018

Background. Class III beta-tubulin (TUBB3) is one of the eight beta tubulin isotypes identified in human. It is constitutively expressed in brain and testis but not in lung tissue. TUBB3 is also known to appear in solid tumors, in particular in non-small cell lung cancer (NSCLC), and it is often associated with poor prognosis and resistance to taxanes and Vinka alkaloids. Objective: We have suggested that TUBB3 expression may cover not only the primary tumor but also a wide adjacent area of morphologically normal lung tissue. To check the hypothesis we have measured TUBB3 expression both in the non-small cell lung carcinoma (NSCLC) and remote lung tissue derived from the same lung. 60surgical biopsy specimens of NSCLC and morphologically normal lung tissue of 30patients were investigated. Materials and methods. Biopsy specimens were converted to suspension, fixed in 4 % formaldehyde and analyzed by flow cytometry using monoclonal antibodies to TUBB3. The method was developed in the laboratory of medicinal chemistry research Institute of experimental diagnostics and therapy of tumors (N.N. Blokhin Russian Cancer Research Center) and patented. Results. Fraction of TUBB3-positive cells in the group of adjacent lung tissue specimens was lower compared to NSCLC group but still positive in the majority of adjacent lung tissue specimens (25 of 30) and achieved up to 39 % of cells. Conclusion. We suggest that TUBB3 expression in adjacent morphologically normal lung tissue indicates presence of transformed and potentially malignant cells far from the primary site.
Antitumor activity of Ormustine against transplanted leukemia in mice
Authors: Saprykina N. S. , Borisova L. M. , Kiseleva M. P. , Smirnova Z. S. , Krasnov V. P. , Levit G. L. , Musiyak V. V. , Baryshnikova M. A. , Bukhman V. M. , Shprakh Z. S. , Davydov M. M.
Published: November 2018

Objective: Evaluation of antitumor activity of a novel alkylnitrosoureas derivative Ormustine (an alkylnitrosocarbamoyl L-ornithine) in mouse lymphoid leukemia models. Materials and methods Antitumor activity of Ormustine has been evaluated in B6D2F1 mice with ascites form of leukemia (L1210, L1210/arenosa, L1210/citrullin and P388) and the solid (P388) form. In this study we used preparations from the alkylnitrosourea group: Ormustine, Aranoza and Lizomustine. Treatment of animals was started 24 hours after inoculation of leukemia intraperitoneally, and 48 hours after inoculation subcutaneous P388. Drugs in a wide range of doses were administrated once intravenously. The follow up period of the animals continued until their death. Criteria of antitumor effect were increasing life expectancy and cure. Evaluation criteria of antitumor effect was the increase in life of experimental mice compared to control ones. Results. Antitumor activity of a novel alkylnitrosoureas derivative, Ormustine has been studied in vivo on the growth of transplanted lymphoid leukemia, such as L1210 (ascites version) and P388 (ascites and solid tumor). Effective dose of single intravenous injection Ormustine against lymphoid leukemia L1210 and P388 was 125 mg/kg. The drug effectively inhibited growth of experimental leukemia. The significant part of the mice with limfoleukemia has been cured. We have also established the single intravenous therapeutic dose of Ormustine on L1210 and Р388 leukemia - 125mg/kg of body weight. Conclusion. The data obtained characterizes Ormustin as a promissing anticancer drug.
The most significant etiological factors of the acute and chronic urticaria
Authors: Sobko E. A. , Chubarova S. V. , Soloveva I. A. , Ischenko O. P. , Gordeeva N. V. , Kraposhina A. Yu. , Demko I. V. , Aristarhova L. V. , Nikolaenko E. V. , Volkova L. N.
Published: November 2018

Background. Urticaria is а common disease characterized by the formation on the skin itchy blisters. It is easy to diagnose an urticaria, but it isn’t always simple to treat because of various severity, frequent resistance to antihistamine drugs, a substantial reduction in quality of life. Objective. The purpose of the study is to carry out the retrospective analysis of medical case history of patients with acute and chronic urticaria for identification of the most significant etiological factors of the disease for the optimization of diagnostics and treatment of such patients. Materials and methods. There were analysed 307 medical cards of the patients with various forms of urticaria who were on treatment in the allergology department from 2008 till 2014. The diagnosis was established on the basis on the results of the clinical methods conforming to the standards of diagnosis of this disease, and also specific allergological research. Results. Though patients with acute and chronic urticaria pass examination and treatment in the hospital according to the one medical economic standard, patients with a chronic urticaria demand wider range of diagnostic actions. Respectively, their medical examination is more expensive. Conclusion. Despite on a wide range of the possible reasons of an urticaria, there are patients at whom the provocative factor isn»t taped. Thus, the urticaria is a multicausal disease at which complex examination of the patient is required.
LIPOSOMAL ARANOSE CAN CHANGE MRNA CD95/FAS EXPRESSION LEVEL IN MELANOMA CELL LINES
Authors: Afanasieva D. A. , Misyurin V. A. , Ponomarev A. V. , Luchenko I. M. , Burova O. S. , Baryshnikova M. A.
Published: November 2018

Background. Aranose is alkylating antineoplastic agent with cytotoxic and cytostatic properties. Liposomal form of aranose has advantages compared with traditional dosage form. Another alkylating agent, cisplatin, promotes mRNA increase expression level of genes, which control external apoptosis way. Objective. We assume that liposomal form of aranose can change the CD95/Fas, TNFR1, TNFR2, TRAIL, DR3 and DR4/5 expression level in melanoma cell lines mel Kor, mel Z, mel Mtp, mel Mtp-X, mel Ibr, mel Ch, mel Is and mel R. Materials and methods. There are two forms of aranose were used in this work: liposomal form and traditional diluted form for injection. Melanoma cell lines were incubated with both forms. We used RQ PCR to evaluate mRNA expression mRNA expression of DR3, DR4/5, CD95/Fas, TNFR1, TNFR2 and TRAIL relatively gene ABL. Results. CD95/FAS mRNA expression level was most changeable. Liposomal aranose increase CD95/FAS expression level in mel Ibr and mel Mtp-X cell lines and reduced CD95/FAS expression level in mel Ch and mel Is. Conclusion. Thus, liposomal aranose can change mRNA CD95/FAS expression level in melanoma cell lines. Using this process, liposomal form can affect the apoptotic cell death of melanoma.
REDOX DENDRIMERS
Authors: Stukalov Yu. V. , Grigorieva E. Yu. , Kalygina N. S. , Koldaeva E. Yu. , Masko A. S.
Published: November 2018

Aim of this work was the synthesis of REDOX-dendrimer core, which is tetraglycidyl ether of pentaerythritol, and a dendron, which is a derivative of anthraquinone. Materials and methods. Analytical and preparative chromatography was carried out on a liquid chromatograph SP 8000 (Spectra-Physics (USA)). Chromatograms were recorded using a UV-detector (Spectra-Physics (USA)) and refractive index detector (Jobin-Ivon (France)). The structure was confirmed by PMR (Bruker WH-360 (Germany)) with an operating frequency of 360 MHz. Monitoring of reactions conducted using HPLC. Results. Derivatives of 2-methylanthraquinone were synthesized and isolated by use of preparative HPLC. Their structure was determined by PMR-spectroscopy. They were used as a dendron in the synthesis of dendrimer. Its toxicity was studied in male mice ВDF1. Redox dendrimers containing methylanthraquinone derivatives in its structure were synthetized. Low toxicity of obtained REDOX-dendrimer was shown. Conclusion. The similarity of REDOX-dendrimer structure with doxorubicin and its low toxicity provides background for further study of its antitumor activity.
MODELING OF A SUBCUTANEOUS XENOGRAFT OF HUMAN SKIN MELANOMA MEL CHER WITH V600E BRAF MUTATION IN IMMUNODEFICIENT MICE FOR PRECLINICAL STUDY THE TARGETING ANTICANCER DRUGS
Authors: Andronova N. V. , Morozova L. F. , Mikhailova I. N. , Lushnikova A. A. , Ponkratova D. A. , Raychlin N. T. , Bukaeva I. A. , Borisova U. A. , Sitdikova S. M. , Treshalina H. M.
Published: November 2018

Introduction. Development of new models of a human disseminated skin melanoma of the with molecular-genetic targets for specific therapy increases productivity of the preclinical researches new the anti-melanoma drugs or their combinations in vitro and in vivo. Such opportunity is realized by adaptation in vivo of the original human pigmented skin melanoma cell line mel Cher and receiving subcutaneous (s. c.) xenograft under monitoring of transplant, morphological, molecular-genetic (V600E BRAF mutation) and chemotherapeutic (sensitivity for the inhibitor of BRAF kinases to a vemurafenib) characteristics. Objective: receiving from the cell line mel Cher s. c. xenogratft of the human pigmented skin melanoma with V600E BRAF mutation and sensitive to specific target therapy. Materials and methods. Human pigmented skin melanoma cell line mel Cher from the Collection of Russian Cancer Research Center and immunodeficient Balb/c nude female mice cultivated in Russian Cancer Research Center was used. Required characteristics are defined by multiple s. c. transplanting in vivo by methods of transplant biology, a light microscopy, molecular-genetics and the experimental chemotherapy. Sensitivity to a BRAF kinase inhibitor to a vemurafenib was estimated under monitoring of the tumor growth rate (Vt/V0) on indexes, adequate for patients: existence of the complete remission and possibility of recurrence. Results. When s. c. transplantation of 107 cell of mel Cher line cytological identical intertwined s. c. xenografts with a stable growth kinetics on 4-9 passages (a latent phase 8 days, exponential - to 14 days, stationary - to 24 days) and existence of a mutation of V600E BRAF have been recieved. Vemurafenib in a single dose of 75 mg/kg caused the complete remission during a 15-day course and within 7 days after its cancellation - with the subsequent recurrence. Conclusion: receiving from the cell line mel Cher s. c. xenogratft of a human pigmented melanoma of skin with a mutation of V600E BRAF and sensitive to specific target therapy is suitable for preclinical studying of the new anti-melanoma drugs specific for this target.
Is there an association between prostate cancer and human papillomaviruses?
Authors: Volgareva G. M.
Published: November 2018

Prostate cancer (PC) incidence and mortality are growing steadily the world over including Russia. PC incidence in 2014 made up 14.3 % of all male tumors in the Russian Federation. PC mortality growth rate since 2004 turned out to be topmost among all men’s cancers. PC etiology is poorly understood yet. Thus the role of human papillomaviruses (HPV) belonging to the highly oncogenic types is unclear while in some other human organs they were proven to be powerful carcinogens. Communications keep on emerging from various laboratories by authors who make mutually exclusive conclusions on the role of these viruses in PC genesis. It seems urgent to clarify the given problem from both theoretical and practical viewpoints. Firstly, this is the way to specify the origin of such a common cancer type as PC is. Secondly, if PC association with oncogenic HPV is confirmed the outlook for PC prevention is discovered by means of inoculating of boys with the vaccines designed for cervical cancer prevention. The present review of the literature contains analysis of data on possible HPV involvement in PC genesis.
THE SEARCH FOR THE SHORTEST ROUTE FOR TOURISTS VISITING SIGHTSEEING OBJECTS OF THE RAZNA NATIONAL PARK
Authors: Grabusts Peter , Musatovs Jurijs
Published: November 2018

The aim of the paper is to popularize the Razna National Park’s tourist attractions. The opportunity to choose the shortest route to visit all the most interesting potential sightseeing objects is offered. The authors continue their research on the theoretical and practical aspects of searching for the shortest route. Theoretical research has been carried out and mathematically the shortest route has been calculated for various sightseeing objects of the Razna National Park. The paper also provides mapping of these objects and an analysis of the locations of the sightseeing objects at different levels. The main goal of the paper is to show the possibilities of applying mathematical models in solving practical tasks – to determine the shortest route between the sightseeing objects. This research describes an optimization method called Simulated Annealing. The Simulated Annealing method is widely used for various combinatorial optimization tasks. Simulated Annealing is a stochastic optimization method that can be used to minimize the specified cost function given a combinatorial system with multiple degrees of freedom. In this paper, the application of the Travelling Salesman Problem is demonstrated, and an experiment aimed to find the shortest route between the Razna National Park sightseeing objects is performed. Common research methods are used in this research: the descriptive research method, the statistical method, mathematical modelling.
START-UPS – AN ELEMENT FOR ECONOMIC GROWTH AND INNOVATIVENESS
Authors: Vonoga Aija
Published: November 2018

The theme of this paper is ,,Start-ups – an Element for Economic Growth and Innovativeness”. Start-ups are innovation of entrepreneurship and a lot of press, scientific literature have articles on this term.  In the paper, the author reviews available definitions for the concept of  ,,start-up’’ in the literature. The aim of the research is the identification of main aspects of term ,,start-up”  and determination, analysis of the term in accordance with the requirements of the modern entrepreneurship and its development trends. Tasks of the paper: to find out the term meaning and main aspects of the term ,,start-up”; to analyze the ,,start-up”  impact on entrepreneurship; to develop  conclusions and suggestions. The key results: the author concludes that the start-up is a company designed to scale very quickly, the main aspect of start-up is its ability to grow, focused on solving a problem, where the solution is not obvious and success is not guaranteed. In articles and papers on start-ups each author suggests an interpretation of the concept according to his/her view. The author suggests the start-up companies to create presentations, organize seminars at the regional level, to introduce the public, stakeholders with the main issues in daily work, in order to help new founders to develop the companies.
COACHING EFFECTIVENESS STUDY
Authors: Smirnova Marina , Silinevica Irena
Published: November 2018

Coaching has great opportunities to make positive impact on the development of organizational human resources and organizational capacity as a whole. In Latvia, coaching is not sufficiently developed, partly due to the lack of understanding of its effectiveness. The aim of the research is to perform an analysis of the effectiveness of coaching in human resources management. The theoretical research on the effectiveness of coaching was carried out by using findings of various researchers. An empirical study was carried out at the State Employment Agency of Latvia. The proposals for the development of coaching in Latvia are developed. The following research methods are used: content analysis, comparative analysis, synthesis, and the abstract and logical construction methods. Coaching implementation proposals could be used to develop organizational training strategies.
EVALUATION OF LATVIAN STUDENTS’ LEARNING EXPERIENCE IN THE EUROPEAN EDUCATION AREA
Authors: Grinberga Zalite Gunta , Hernik Joanna , Liepa Evija , Papins Atis
Published: November 2018

The objective of contemporary education is to enhance the competiveness of graduates not only in the local market but also at the European Union scale; therefore, stronger co-operation with foreign education and research institutions can significantly improve the knowledge and skills of Latvian students, which can gradually contribute to Latvia’s competitiveness in high value added activities within global value chains. This, of course, underlines the increasing importance of foreign language skills. In fact, knowledge of the English language in today’s labour market is taken for granted, and the competiveness of those employees, who can speak at least three foreign languages, including one of the Scandinavian languages, is increasing. The aim of the research was to identify Latvian students’ learning experience in European countries in scope of short study mobility programmes. Based on the secondary information sources such as statistical data aggregated by the Ministry of Education and Science of the Republic of Latvia and Flash Eurobarometer Report No466, the authors have analysed Latvian students’ mobility destinations and intentions of studies abroad. The research findings suggest that currently there is a contradiction between students’ personal intentions and their real behaviour. The countries that are currently most often chosen as study mobility destinations rather offer valuable cultural experience than practical skills that could be useful in academic and professional work.
DESIGN DEVELOPMENT TRENDS OF LATGALE REGION NEWSPAPERS (1998 – 2017)
Authors: Pozņakovs Kārlis , Murinska Sandra
Published: November 2018

The aim of the paper is to find out how the design of regional newspapers has changed and what cultural and social factors have affected it.  The paper analyses the design of Latgale region newspapers “Latgales Laiks, “Rēzeknes Vēstis”, “Vaduguns” in three periods from 1998 to 2017. A comparative analysis is made, analysing the processes that have affected the visual communication of cover pages and the content. Content analysis is used as a research method to achieve the aim. In the study, a total of 270 regional newspapers were analysed. During the period from 1998 to 2008, there were changes in the design of the newspapers that took place under the influence of cultural and social factors: higher-quality photographs, colourful content, original design solutions, and official websites of newspapers etc. The changes were found in all three of design disciplines, while the detected newspaper design changes in the period from 2008 to 2017 had not affected the overall visual image of the newspapers.
О Вал. А. Лукове, тезаурусном подходе, других его концепциях и исследованиях
Authors: Ковалева Антонина Ивановна , Кузнецова Татьяна Федоровна
Published: November 2018

В статье представлены биографические данные Валерия Андреевича Лукова на фоне его трактовки тезаурусного подхода и других концепций, выдвинутых им, и исследований, проведенных им и под его руководством. Публикация приурочена к 70-летию ученого.
Гамлет и Офелия как лирические герои в русской поэзии XIX–XX вв.
Authors: Федотов Олег Иванович
Published: November 2018

Статья посвящена достаточно традиционной в литературоведении проблеме активного функционирования Гамлета и Офелии в ролевой русской лирике с начала XIX до конца XX в. Основное внимание уделяется причинам обращения к этим хрестоматийным образам весьма не похожих друг на друга русских поэтов — от Н. А. Некрасова до И. А. Бродского, субъектной организации лирического дискурса, родовой и жанрово-видовой специфике соответствующих текстов, их индивидуально-стилевым и, прежде всего, стихопоэтическим (версификационным) особенностям.
Некоторые аспекты соотношения греха и преступления
Authors: Голубов Игорь Иванович , Денисенко Михаил Вячеславович
Published: November 2018

В статье обращается внимание на значение христианства в формировании основных принципов и институтов уголовного права, в том числе преступления и наказания. Выявлены и показаны некоторые сходные признаки, а также различия греха и преступления. Сделан вывод о различной природе греха и преступления. Отмечается, что духовное возрождение ценностей, не запрещенных законом религиозных конфессий, в значительной степени будет способствовать снижению уровня преступности.

Статья подготовлена на основе доклада на Всероссийской научной конференции «Моисеевские чтения» (Москва, 26 мая 2018 г.).
Коррупция — серьезная проблема для глобального бизнеса
Authors: Калибаева Наталья Сергеевна
Published: November 2018

В статье утверждается, что коррупция является серьезной проблемой для глобального бизнеса, особенно на развивающихся рынках. Иностранное юридическое взяточничество влияет на саму стабильность бизнеса за рубежом. Иностранные корпоративные взятки также влияют на внутреннюю конкурентную среду, уничтожая здоровую конкуренцию при ведении бизнеса. Если акции компании котируются на фондовой бирже США и / или она находится в США, а ее представители были уличены во взяточничестве в сфере бизнеса во время посещения США, то это может повлечь их уголовное преследование в рамках Закона о коррупции за рубежом (FCPA). Автор отмечает, что в России необходимо разработать руководство для компаний в сфере организации деятельности по противодействию транснациональной корпоративной коррупции.

Статья подготовлена на основе доклада на Всероссийской научной конференции «Моисеевские чтения» (Москва, 26 мая 2018 г.).
Pensando de Manera Crítica sobre el Pensamiento Crítico
Authors: Ross E. Wayne , Gautreaux Michelle
Published: November 2018

RESUMENDesde hace tiempo la manera dominante para enseñar el pensamiento crítico en las escuelas ha sido a través de un enfoque basado en el desarrollo de habilidades. Este enfoque pone su énfasis en la instrucción directa para enseñar habilidades de pensamiento crítico discretas, ofreciendo a los alumnos oportunidades para practicar la aplicación de habilidades de pensamiento y ayudándoles a trasladar habilidades de pensamiento crítico de un contexto a otro. En este trabajo, se propone construir el pensamiento crítico desde un enfoque más holístico basado en la dialéctica, que complemente, o más bien sustituya, la lógica formal con un enfoque que analice la forma en que están las cosas, sus historias y la manera en que las cosas cambian.Palabras Clave: Pensamiento crítico, Enfoque dialéctico. ABSTRACTFor a long time the dominant way to teach critical thinking in schools has been a way with a focus on skill development. This approach emphasizes direct instruction to teach discrete critical thinking skills, offering students opportunities to practice applying thinking skills and helping them transfer critical thinking skills from one context to another. In this paper, we propose to conceive critical thinking with a more holistic approach based on dialectics, which complements, or rather substitutes, formal logic with an approach that analyzes the way things are, their histories and the way in which things change in the world.Keywords: Critical thinking, Dialectical approach.
La “buena universidad” desde la experiencia crítica
Authors: Morales Isabel , Reina Onowa , Manzano-Arondo Vicente
Published: November 2018

RESUMENExiste ya una gran acumulación de trabajos que critican el modo en que la universidad se está concretando, tanto a nivel local comomundial. Las principales críticas se centran en la orientación mercantil, tanto como en el abandono de la identidad basada en laconstrucción colectiva y desinteresada de conocimiento. A pesar de la envergadura de la crítica, las publicaciones no abundan enla descripción de alternativas, que reciben comparativamente muy poco esfuerzo. Se observa, además, que los procesos de cambiose afianzan con rapidez y poca resistencia, por lo que resulta ya urgente dar forma a modos alternativos de hacer universidad. Porello, este trabajo plantea un diagnóstico crítico sobre la institución actual, pero se sitúa en una clara perspectiva propositiva. Para ellorealiza una investigación empírica mediante entrevistas en profundidad a 16 miembros del profesorado universitario español que hanpublicado trabajos críticos en torno a la universidad y a principios rectores o propuestas concretas. El objetivo fue no solo describirsomeramente la universidad que contempla este profesorado experimentado sobre el asunto, sino también identificar barreras para suconsecución y posibles soluciones. Los resultados permiten identificar varias categorías relevantes y diseñar un guion de trabajo paraorientar el proceso hacia la buena universidad.Palabras Clave: Buena universidad, Universidad crítica, Revolución universitaria, Transformación de la universidad.ABSTRACTThere is already a great accumulation of work that criticize the way in which the university is specifying itself, both locally and globally.The majority of the criticism focuses on the commercial orientation, as well as on the abandonment of identity based on the collectiveand uninterested construction of knowledge. Despite the magnitude of the criticism, publications do not abound in the description ofalternatives, which receive comparatively very little effort. It is also observed that the processes of change take hold quickly and withlittle resistance, therefore it appears to be urgent to give shape to alternative ways of making universities. Therefore, this work is placedin a clear propositional perspective. To do this, it conducts an empirical investigation through in-depth interviews with 16 members ofSpanish university teaching staff who have published critical works about the university. The objective wasn’t only the mere descriptionthat these experienced professors contemplate but to also identify the barriers for its achievement and possible solutions. The resultspermit to identify various relevant categories and design a work script to guide the process towards good university.Keywords: Tgood university, Critical university, Revolutionary university, Transformation of the university.
El compromiso social de la universidad a través de la transferencia de conocimiento en el ámbito de la investigación en Pedagogía Social
Authors: Melendro Miguel , De-Juanas Ángel , García-Castilla Francisco Javier , Valdivia Paloma
Published: November 2018

RESUMENLa universidad del nuevo milenio debe ser capaz de producir investigación de calidad, que dé lugar a innovaciones orientadas a mejorar el bienestar de la sociedad de su tiempo. Partiendo de ello, el objetivo del estudio ha sido explorar el grado de compromiso con la sociedad de la investigación universitaria en pedagogía social, a través de un sistema de indicadores sobre procesos activos de transferencia de conocimientos. Se da respuesta a este objetivo a través de un estudio exploratorio de 47 investigaciones, realizadas por 41 grupos de investigación y en las que han participado 131 universidades entre 2013 y 2018. El estudio aporta la construcción de un sistema de indicadores de transferencia de conocimiento en pedagogía social, su aplicación y una primera panorámica de la posición de la pedagogía social en relación con la “tercera misión” de la universidad. Los resultados obtenidos muestran un buen posicionamiento, con investigaciones diversificadas en temáticas, población de referencia y  metodologías de investigación; proyectos consistentes y de calidad, trabajados muy frecuentemente en red y desde un prisma interdisciplinar, y sobre todo con impacto académico, pero también un elevado impacto social y profesional. Sin embargo, se detecta una escasa formalización en cuanto al registro de la transferencia social y profesional.Palabras Clave: Transferencia de conocimiento, Investigación, Universidad, Pedagogía social, Indicador.ABSTRACTA new millennium university must be able to produce high quality research which results in innovation focused on improving the wellbeing of its time´s society. On this basis, this research’s objective has been to study universities and their degree of commitment with their research on Social Pedagogy. This has been done using an indicators system of knowledge transfer active rocesses. The answer to this goal has been provided through an exploratory study of 47 researches, done by 41 research teams in which 131 universities have participated between 2013 and 2018. The study provides the construction of a knowledge transfer indicators system in Social Pedagogy, its application and a first panoramic perspective of Social Pedagogy’s position in terms of a university’s “third mission”. The results show a good positioning, with researches diversified on subjects, population and research methodologies. There are consistent and good quality projects, often interdisciplinary and networked, with academic impact and especially with a great social and professional impact, even though there is a lack of formalisation in terms of registering this social and professional transfer.Keywords: Knowledge transfer, Research, University, Social pedagogy, Social education, Indicator.
Un estudio exploratorio sobre los errores y las dificultades del alumnado de Bachillerato respecto al concepto de derivada
Authors: González-García Antonio , Muñiz-Rodríguez Laura , Rodríguez-Muñiz Luis José
Published: November 2018

RESUMENLos errores que comete el alumnado al resolver una tarea matemática suponen una herramienta poderosa para detectar dificultades en el aprendizaje de esta disciplina. Su diagnóstico permite el desarrollo de técnicas de enseñanza que eviten o remedien su cometido. Este artículo presenta los resultados de un estudio exploratorio cuyo objetivo es analizar los errores que comete el alumnado al estudiar el concepto de derivada de una función. Para ello se examinaron los errores cometidos por 27 estudiantes de 1º de Bachillerato durante la resolución de una serie de ejercicios. Los resultados permiten identificar aquellas categorías en las que los estudiantes cometen mayores errores en el estudio de la derivada. El análisis también revela dificultades causadas por un aprendizaje deficiente de conocimientos previos. Todo ello invita a reflexionar sobre la necesidad de fomentar un análisis lógico y coherente de los conceptos, del lenguaje y de las soluciones, a la hora de resolver problemas matemáticos.Palabras Clave: Bachillerato, Derivada, Dificultades, Errores, Matemáticas.ABSTRACTThe errors that students make when solving a mathematical problem are a powerful tool to detect difficulties in the learning of this discipline. Their diagnosis allows the development of teaching techniques that avoid or rectify their commission. This article presents the results of an exploratory study which aims at analyzing the errors that students make when studying the concept of derivative of a function. To this end, the errors made by 27 high school students during the resolution of a series of exercises are examined. The results allow to identify those categories in which students make a higher number of errors when studying the derivative. The analysis also reveals difficulties caused by poor learning of prior knowledge. The later invites to reflect on the need to promote a logical and coherent analysis of concepts, language and solutions, when solving mathematical problems.Keywords: Derivative, Difficulties, Errors, High school, Mathematics.
La publicidad con ojos de niño: imaginarios infantiles y construcción crítica de significados
Authors: Gómez-Montoya Paola Andrea , Castro Zubizarreta Ana , Aguadez Gómez José Ignacio
Published: November 2018

RESUMENEl estudio pretende recoger la mirada infantil sobre la publicidad para comprender qué sentido e influencia tiene en la vida de los niños y en la forma de construir significado a su mundo. Los niños conviven con mensajes publicitarios, de ahí nuestro interés por recoger su mirada al respecto. Para ello, hemos contado con el apoyo voluntario de 184 niños de la ciudad de Cali (Colombia) con edades comprendidas entre los 7 y los 12 años. En esta investigación se empleó la técnica de talleres, que combinó tres actividades participativas involucrando el dibujo, la escritura y la conversación espontánea. Los resultados del estudio evidencian cómo la publicidad se ha asentado silenciosamente en la vida de los niños generando un imaginario infantil que marca un estilo de vida y una cotidianidad consumista. Términos afines a la publicidad desde la perspectiva infantil son fama, consumo y marcas. Conceptos que tienen presencia en sus aspiraciones y proyecciones. El estudio recoge lo que el niño imagina sobre el tema de la publicidad y cómo la apropia invitando a reflexionar sobre el tratamiento y la generación de prácticas educativas que fomenten que los niños lean e interpreten críticamente los mensajes publicitarios.Palabras Clave: Imaginarios, Publicidad, Procesos de escucha, Participación, Infancia.ABSTRACTThe study aims to collect the children’s perspective on advertising to understand what sense and influence advertising has in the lives of children and how to build meaning in their world. The children live with advertising messages, hence our interest to collect their eyes on it. For this, we have had the voluntary support of 184 children from the city of Cali (Colombia) aged between 7 and 12 years old. This research used the workshop technique, which combined three participatory activities involving drawing, writing and spontaneous conversation. The results of the study show how advertising has settled silently in the lives of children generating a childish imagery that marks a lifestyle and a consumerist every day. Terms related to advertising from the perspective of children with fame, consumption and brands. Concepts that have a presence in their aspirations and projections. The study gathers what the child imagines about advertising and how appropriate it inviting to reflect on the treatment and the generation of educational practices that encourage children to read and critically interpret the advertising messages.Keywords: Imaginaries, Advertising, Processes of listening, Participation, Childhood.
Evaluating the liberalization process on Telecommunications services for EU countries
Authors: Agiakloglou Christos , Polemis Michael
Published: November 2018

This paper investigates the main determinants of Telecommunications demand for European Union (EU) countries using a panel data set for 19 EU countries over the period 1991-2010, capturing the years before and after the liberalization process.  The goal is to clarify whether any changes in the demand of Telecommunications, as expressed by volume of traffic in local, mobile and international market segments, are attributed to regulatory process or to some other major drivers, taking also into account the relevant price elasticities.  It turns out that the regulatory process does not seem to have significant impact on demand for Telecommunications services for the first period of liberalization.
C-reactive protein as a screening test for gestational diabetes mellitus in first-trimester of pregnancy: a prospective cohort study
Authors: Farghaly Tarek A. , Helmy Neveen A. , Abbas Ahmed M. , M. Ahmed Abdel Ghaffar
Published: November 2018

Background: The current study aims to determine if increased inflammation identified by increased C-reactive protein (CRP) level is associated with the subsequent development of gestational diabetes mellitus (GDM).Methods: A prospective cohort study conducted at a tertiary University Hospital included 496 booking for their antenatal care visit between 10-12 weeks of gestation. They were tested for presence of CRP in blood. All women without a history of antenatal type 1 or type 2 diabetes undergo routine GDM screening with the 50-g oral glucose-loading test (GLT) between 24 and 28 weeks 'gestation. Women whose 1-h post-loading plasma glucose level >7.8 mmol/l (>140 mg/dl) undergo a diagnostic, fasting, 100-g, 3-h oral glucose tolerance test (OGTT) within 1-2 weeks following the GLT.Results: Among these 496 women, a total of 27 women (5.4%) were diagnosed as GDM and 10 women (2.0%) were diagnosed as IGT at week 24-28. The CRP was positive and higher in the GDM diagnosed group (p=0.000) compared to those who did not develop GDM. CRP was positively correlated with diagnosis of GDM (r=0.438, p=0.012).Conclusions: There is an association between first-trimester inflammation, marked by increased CRP levels and subsequent risk of GDM.