bluuebunny/crossref_metadata_2025 huggingface dataset:
As Tecnologias Digitais e as Relações Interpessoais no Cotidiano das Instituições Educativas
Authors: Dos Santos Diana Leonhardt , Machado Karen Graziela Weber
Published: April 2020

Observa-se o crescente uso das tecnologias digitais por pessoas de diferentes idades e em diversos contextos. No cotidiano das instituições educativas, da educação básica ao ensino superior, as ferramentas digitais podem auxiliar o professor a promover uma aula mais significativa e interativa, assim como podem facilitar as relações interpessoais, promovendo espaços além da sala de aula. Este estudo tem por objetivo analisar a produção científica sobre o uso das tecnologias e o desenvolvimento das relações interpessoais no cotidiano das instituições educativas em pesquisas produzidas no Brasil, entre o período de 2015 a 2019. A metodologia utilizada se refere aos princípios de estado de conhecimento e tem como fonte principal a Biblioteca Digital Brasileira de Teses e Dissertações - BDTD. O corpus de análise constituiu-se por doze (12) dissertações e seis (6) teses, totalizando 18 produções. A partir da análise da bibliografia foram levantadas três categorias: uso das tecnologias digitais na aprendizagem dos estudantes; impacto das tecnologias digitais no cotidiano dos estudantes; formação de professores no cotidiano das instituições educativas. Os resultados apontam que as tecnologias digitais estão presentes desde muito cedo na vida de crianças e jovens, impactando nas suas relações interpessoais e na forma de verem o mundo. Foi possível compreender que a unidade educativa deve aproveitar as vantagens e potencialidades das tecnologias digitais, visando favorecer o desenvolvimento de aprendizagens significativas aos estudantes do Século XXI, preparando-os para atuar no mundo que o rodeia de maneira saudável e responsável.
O Professor de Educação Física em Formação: o desafio teoria-prática na construção da profissionalidade.
Authors: Florentino José Augusto Ayres , Santos Lucas Souza
Published: April 2020

O presente estudo é fruto de uma pesquisa que tem como objeto a formação inicial de professores, investigando a constituição do campo dos saberes do estudante, professor em formação. Para tanto, partiu-se da seguinte questão: De que forma os estudantes, professores de Educação física em formação, estão constituindo seus saberes, principalmente, no que diz respeito a articulação teoria e prática, incluindo as tensões entre o campo da formação (Faculdade) e o campo profissional (Espaço Escolar) que configuram o exercício da docência na Educação Física, e de que forma estes saberes contribuem para a construção da sua profissionalidade? Este estudo é de abordagem qualitativa, descritiva, de cunho exploratório. Do resultado das análises pode-se destacar que os estudantes, professores de Educação Física em formação, consideram-se responsáveis pelo aprendizado de seus alunos, servindo de referência para os mesmos; a respeito da inserção desde cedo à prática os estudantes consideram como um campo de conhecimento importante para a formação e construção da sua profissionalidade, como um conjunto de comportamentos, conhecimentos, atitudes e valores que constituem a especificidade de ser professor.
Alteridade, ética e diversidades de gênero na (trans)formação de operadores do Direito e da cultura jurídica
Authors: Cheron Cibele , Polônia Camila Paola Fernandes
Published: April 2020

O presente artigo traz ao debate a importância das questões inerentes às diversidades de gênero estarem contempladas na formação dos operadores do Direito. Partimos da constatação do exaurimento da cultura jurídica centrada nos valores e práticas adversariais, de maximização do ganho individualista e desumanização das relações sócio-políticas. O estudo filia-se ao entendimento de que diferentes saberes estão relacionados a diferentes costumes, condutas e práxis. Assim, transformações na matriz de conhecimentos que formam cidadãos têm potencial para produzir transformações nas relações sociais. Adota-se referencial teórico interdisciplinar com aportes das Ciências Sociais, Direito, Educação e Filosofia a fim de avaliar a inserção de temas relativos às diversidades de gênero como obrigatórios nos projetos pedagógicos e currículos de cursos de graduação em Direito de Porto Alegre, RS, e região, conforme a Política de Educação em Direitos Humanos vigente. Destacam-se os conceitos de conflito, política, ética e alteridade, em Jacques Rancière, liberalismo, racionalidade política, lutas transversais e saber-poder em Michel Foucault para sustentar a necessária transformação da cultura jurídica e da formação acadêmica. Afirma-se o potencial individual não como bem em si, mas para que se promova a integração a partir das diferenças e da pluralidade, critério ético pautado pela alteridade e integralidade humana.
A Formação de gestores escolares: a dimensão ética em questão
Authors: Ribeiro Marli Dias , Síveres Luiz , Brito Renato De Oliveira
Published: April 2020

A pesquisa apresenta estudo em duas escolas de Educação Básica do Distrito Federal (DF). O tema tratado é a formação de gestores escolares por competências perpassando resultados de um estudo realizado no curso de mestrado acadêmico em educação. O objetivo foi investigar a relevância da formação continuada oferecida aos gestores escolares e a efetividade dessas formações. Trata-se de uma abordagem qualitativa, instrumentalizada por entrevistas semiestruturadas, observação e pesquisa documental. Participaram da pesquisa seis servidores da Secretaria de Estado de Educação do Distrito Federal que atuam em equipes de gestão escolar em suas respectivas instituições de trabalho. Adverte-se a respeito de uma desvinculação entre a formação ofertada e o contexto de trabalho dos gestores, a necessidade de mais estudos e inserção da formação por competências nos programas de formação continuada ofertados pelas redes de ensino. Sugere-se que se configurem novas abordagens ao processo formativo aprofundando as dimensões pedagógicas e administrativas, porém, fortalecendo a dimensão ética da formação.
Complexidade como uma proposta de desafio para pensar a Educação “fora da caixa”
Authors: Guilherme Alexandre Anselmo , Cheron Cibele
Published: April 2020

Editorial do V.10 n.2.
Maturation of NMDA receptor-mediated spontaneous postsynaptic currents in the rat locus coeruleus neurons
Authors: Kourosh-Arami M , Hajizadeh S
Published: April 2020

Introduction

During mammalian brain development, neural activity leads to maturation of glutamatergic innervations to locus coeruleus. In this study, fast excitatory postsynaptic currents mediated by N-methyl-d-aspartate (NMDA) receptors were evaluated to investigate the maturation of excitatory postsynaptic currents in locus coeruleus (LC) neurons.

Methods

NMDA receptor-mediated synaptic currents in LC neurons were evaluated using whole-cell voltage-clamp recording during the primary postnatal weeks. This technique was used to calculate the optimum holding potential for NMDA receptor-mediated currents and the best frequency for detecting spontaneous excitatory postsynaptic currents (sEPSC).

Results

The optimum holding potential for detecting NMDA receptor-mediated currents was + 40 to + 50 mV in LC neurons. The frequency, amplitude, rise time, and decay time constant of synaptic responses depended on the age of the animal and increased during postnatal maturation.

Conclusion

These findings suggest that most nascent glutamatergic synapses express functional NMDA receptors in the postnatal coerulear neurons, and that the activities of the neurons in this region demonstrate an age-dependent variation.
Levels of protein C, protein S, and anti-thrombin III in acute ischemic stroke patients at Haj Adam Malik Hospital, Medan
Authors: Muchti Jenie Erawati , Anwar Yuneldi , Aman Adi Koesoema
Published: April 2020

Background: Ischemic stroke is a clinical syndrome with rapid brain function loss due to a disturbance of blood supply to the brain. The role of natural anticoagulants protein C, protein S and antithrombin III (AT III) in ischemic stroke is still unknown. This study aimed to determine the differences in the levels of protein C, protein S and AT III, which were examined on days 1, 3 and 7 of acute ischemic stroke during treatment.Methods: This was a longitudinal prospective study carried out in Haj Adam Malik General Hospital Medan, from January to May 2018. This study included 21 acute ischemic stroke patients with three times of sampling (day 1, 3 and 7). Protein C, protein S and AT III were examined using the Coatron A4 device. Protein C and AT III were examined using chromogenic assay principles and protein S using clotting assay principles.Results: Twenty-one patients who participated in this study were 12 men (57.1%) and nine women (42.9%). There was no significant difference in the level of protein C (p = 0.980), protein S (p = 0.680) and AT III (p = 0.872) between day 1, 3, and 7. There was a positive correlation in protein C, protein S and AT III levels between day 1, 3, and 7. There was a negative correlation between protein C and AT III levels on day 3 (r: - 0.498; p: 0.022).Conclusion: There was no significant difference in the level of protein C, protein S and antithrombin III between day 1, 3, and 7.
Pregnant gymnastics, ANC, and IEC pregnancy lower the stress on pregnant women
Authors: Prasetyawati Nurlaily , Tamtomo Didik Gunawan , Hanim Diffah , Salimo Harsono
Published: April 2020

Background: Psychosocial stress in pregnant women is one of the factors that cause the disorder of metabolism for pregnant women. Maintaining physical and mental health on a pregnant woman can be conducted by ANC, pregnant gymnastics, and IEC pregnancy to optimize health degrees while pregnant and expedited the process of childbirth.Aim: This study aimed to analyze the relationship of the gymnastics, ANC, and the IEC pregnancy with stress rate on pregnant women.Methods: This was an observational analytical with a case-control approach. The subject of this study was the mother of a toddler as many as 390, ages 2 to 2.5 years that live settled in Klaten Regency, Karanganyar and Sragen.Results: Stress while pregnant is significantly associated with the gymnastics pregnant (p = 0.023; CI 0.38-0.93; OR 0.69), ANC (p = 0.001; CI 0.01-0.57; OR 0.75) and IEC of pregnancy (p = 0.049; CI 0.45-1.00; OR 0.69).Conclusion: Stress during pregnancy can be reduced by doing pregnant gymnastics and the ANC. Granting education can also be used as an alternative to reduce stress during pregnancy.
The role of serum albumin level within the first 24-hours of hospitalization to the mortality risk in burn patients at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
Authors: Muthiah Ummi , Rostini Tiene , Tristina Nina
Published: April 2020

Introduction: Serum albumin level may predict the mortality risk in burn patients. This study aimed to determine the mortality risk in burn patients based on serum albumin level within the first 24 hours of hospitalization.Method: A cross sectional study was conducted reprostecively to the patientâ€™s medical records. The subjects were burned patients who were hospitalized in Dr. Hasan Sadikin General Hospital Bandung during January-December 2017. The subjects were divided into two groups, which were dead and survived at the end of hospitalization. The mortality risk based on serum albumin level within the first 24 hours of admission was assessed using the odds ratio (OR) of two groups. Data were analyzed using SPSS version 17 for windows.Result: The subjects were 47 patients, consisted of 9 dead subjects and 38 survived subjects. Males were predominant in both groups such as 12.8% in dead subjects and 70.2% in survived subjects. The OR value based on serum albumin level <2 g/dL within the first 24 hours of hospitalization was 14.40 (p=0.009; CI:2.1â€“100).Conclusion: The subjects with serum albumin level <2 g/dL within 24 hours of hospitalization has 14 times higher mortality risk compared to the subjects with serum albumin level >2 g/dL. Therefore, burn patients need to be examined for serum albumin level within the first 24 hours of hospitalization.
Myelodysplastic Syndrome (MDS) in a Child who Transformed to Acute Myeloid Leukaemia with Myelodysplasia-Related Changes (AML-MRC)
Authors: Parmawati Ni Komang Ayu , Herawati Sianny , Wande I Nyoman
Published: April 2020

Background: Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell diseases, accounting forÂ  < 5% of all hematologic malignancies in children. Â MDS is characterized by cytopenia, dysplasia in one or more of the major myeloid lineages, ineffective hematopoiesis, and recurrent genetic abnormalities. Approximately 30% of patients with MDS show progression to AML within a few months up to several years. This is an MDS case report in children who have undergone Acute Myeloid Leukaemia transformation with Myelodysplasia-Related Changes (AML-MRC).Case Report: A 16-year-old boy came to the Emergency Department of Sanglah General Hospital with a complaint of pain and swelling in both knees and joints since last month. Fatigue and fever happened a week before admission. Previously, he had been hospitalized twice with the same symptoms. Physical examination revealed pale conjunctiva with pancytopenia in the laboratory result. A blood smear showed normochromic normocytic anemia, neutropenia, and thrombocytopenia. Bone marrow aspiration morphology showed hypercellularity with blast presentation > 10% and multilineage dysplasia > 50% supporting MDS diagnosed transformation to Acute Myeloid Leukaemia with Myelodysplasia-Related Changes (AML-MRC). Leukemia phenotyping showed positive results on CD 33, CD 36 and HLA-DR presenting Monocytic Lineage.Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â  Conclusion: High degree dysplasia and blast percentage in blood and bone marrow increase tendency to transform into acute myeloid leukemia (AML). The diagnose of MDS requires analysis of blood and bone marrow morphology and cytogenetic analysis as a recommendation by WHO classification.
Coagulation Defects in Î’eta-Thalassemia Major Patients at Haji Adam Malik Hospital Medan
Authors: Situmorang Eduward , Aman Adi Koesoema , Lubis Bidasari
Published: April 2020

Background: The prognosis of patients with beta-thalassemia major has improved in the last few decades, but some complications occur in thalassemia patients such as the prolongation of blood coagulation time. This study aimed to determine the difference in prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin time (TT) between beta-thalassemia major patients and healthy children, frequent and infrequent transfusion, and ferritin levels â‰¥ 2,500 ng/ml and < 2,500 ng/ml.Method: This was an analytical cross-sectional study performed at Haji Adam Malik Hospital from April to August 2018 including 20 thalassemia patients and 20 healthy children. Patient data consisted of full blood count, transfusion status, coagulation parameters, serum iron, and ferritin level. The difference between coagulation parameters was analyzed using the independent t test.Result: There was a significant difference in PT and aPTT between patients with thalassemia and healthy children (15.7 Â± 1.5 vs. 13.0 Â± 1.0; 42.5 Â± 4.8 vs. 36.3 Â± 4.8 respectively). There was a significant difference in PT between frequent and infrequent transfusion (15.41 Â± 1.30 vs. 17.16 Â± 2.08). There was significant difference in PT and aPTT between ferritin levels â‰¥ 2,500 ng/ml and < 2,500 ng/ml (18.97 Â± 0.57 vs 15.93 Â± 1.18; 52.92 Â± 1.17 vs 42.11 Â± 3.88 respectively).Conclusion: There was a prolongation of PT and aPTT in beta-thalassemia major patients and ferritin levels â‰¥ 2,500 ng/ml. There was also an elongation of PT in patients who had infrequent transfusions.
Hyperferritinemia and oxidative stress in the kidney of beta thalassemia major
Authors: Ariningrum Dian , Adhipireno Purwanto , Suromo Lisyani Budipradigdo
Published: April 2020

Background: Thalassemia is a genetic disorder which until now has become a global health problem. Regular blood transfusions in managemen of BTM result in iron overload. Free iron in the form of intracellular ferrous (Fe2+), in the presence of oxygen, will initiate the formation of reactive oxygen species (ROS), produce another free radical superoxide that will oxidize the lipid and protein compounds of the cell membrane. F2-IsoPs is the best, most stable and more accurate marker of lipid peroxidation in vivo, found urine. This study aimed to determine the association between hyperferritinemia and lipid peroxidation in kidney reflected as elevated u-F2IsoPs as controlling several factors affecting oxidative stress in the kidney.Methods: This cross sectional study was conducted between May and June 2016. Thirty subjects of BTM admitted to pediatrics unit of Dr. Moewardi Hospital Surakarta who met the inclusion and exclusion criteria were enrolled. The data were analyzed to calculate prevalence ratio and 95%CI for each variable, followed by multivariate analysis with logistic regression.Results: The prevalence of lipid peroxidation in kidney, characterized with elevated u-F2IsoPs of > 2 ng/mg urine creatinine, was 67%. Age, hyperferritinemia status and duration of illness did not associate with lipid peroxidation in the kidney. Transfusion volume of â‰¥25 unit/year showed statistically significant association with lipid peroxidation (PR 24.10; 95%CI 2.16-268.42; p=0.010).Conclusion: Transfusion volume, rather than hyperferritinemia, independently associated to oxidative stress and lipid peroxidation of the kidney in BTM.
Cytogenetic mutation in a family with sickle-cell beta-thalassemia in North Sumatera, Medan, Indonesia: A preliminary study
Authors: Andani Christie Nur , Aman Adi Koesoema , Hariman Herman , Lubis Bidasari
Published: April 2020

Background: The prevalence of Â Hb S/Î² Thalassemia has not been widely reported, and until now, there is a lack of statistical data on the prevalence of the disease in Indonesia. In 1974, cases of Î² thalassemia with Hb S were found in one family in Jakarta. The aim of this study was to describe the cytogenetic mutation in a family with Hb S/Î² thalassemia in North Sumatera.Methods: This was a descriptive study with a cross-sectional design conducted in one family of HbS patients with thalassemia trait, with a total of five samples. Complete blood count, hemoglobin electrophoresis examination, peripheral blood smear, PCR, and amplicon were performed to describe the hematology and cytogenetic profile of samples. Data were analyzed descriptively.Results : The father (64 years old) suffered from HbS (HbA = 58.3%, HbS = 38.3%, HbA2 = 2.8%) with heterozygote HbS mutation type. The mother (36 years old) suffered from Î²-thalassemia trait (HbA = 93.8, HbF = 1.2%, HbA2 = 5%) with Î²-thalassemia heterozygote IVS1-nt5 mutation type. The first child (male, 18 years old) suffered from HbS/Î² thalassemia (HbA = 25.9%, HbF = 22.4%, HbS = 48.2%, HbF = HbA2 = 3.5%), the second child was normal (HbA = 97.4%, HbA2 = 2.6%) and the third child (female, 10 years old ) suffered from HbS Î²-thalassemia (HbA = 3.3%, HbF = 25.5%, HbS = 67.6%, HbA2 = 3.6%). The first and third child had Î²-thalassemia with double heterozygote HbS and IVS1-nt5 mutation type.Conclusion: Population migration between nations followed by marriage could lead to cytogenetic mutations and cause sickle-cell beta-thalassemia. The finding of double heterozygous HbS mutation and beta thalassemia need to be explored further about the patientâ€™s fathers family.
The mucin 5AC level in medical faculty students with Computer Vision Syndrome (CVS)
Authors: Juliari I Gusti Ayu Made , Sari Dewi Ratna , Ratnasari Ni Luh Made Novi , Tri Handayani Ariesanti
Published: April 2020

Introduction: Prolonged computer use will lead to a group of symptoms such as dryness of eyes, tired, headache and others called Computer Vision Syndrome (CVS). The decrease of Mucin 5 AC (MUC5AC) level could be one of the signs of dry eye disease on persons with CVS.Objective: The purpose of this study is to describe the Mucin 5AC level in medical faculty students of Udayana University, Bali, Indonesia with CVS.Method: It is an observational cross-sectional analytic study at Medical Faculty Udayana University on October 2018. Thirty four subject selected Â by purposive sampling and examined with Schirmer I test, Tear Break Up time (TBUT) test, and Mucin 5AC test. All of the subject then divided into CVS group and non-CVS group. Mucin 5AC level which less than 186.33 ng/mL categorized as low mucin, while more than 186.33 ng/mL categorized as normal mucin level. Data was analyzed by crosstabulation table and chi-square test with significant value p < 0.05.Result: Most of the students who diagnosed with CVS had lower mucin 5AC levels as much as 77,3% and 33,3% students with CVS had normal mucin 5AC level. Â This study analyses found there is significant association between level of mucin 5AC with CVS. The students with low level of mucin 5AC had 6,8 higher risk tend to be CVS (OR=6,8; CI 95%= 1,42-32,37; p=0,012).Conclusion: Low level of mucin 5AC has association with the risk of CVS in the medical students with prolonged computer use.
The relationship between Epidermal Growth Factor Receptor (EGFR) mutation and computed tomography findings in lung adenocarcinoma
Authors: Septiani Agnes , Dewi Pande Putu Ayu Patria , Widyoningroem Anita , Sensusiati Anggraini Dwi , Yamin Muhammad
Published: April 2020

Background: Adenocarcinoma is the highest histology subtype of lung cancer. Epidermal Growth Factor Receptor (EGFR) is a factor that can predict the prognosis or response to treatment in patients with lung adenocarcinoma. Adenocarcinomas with EGFR mutations generally have a component of Ground Glass Opacity (GGO), smaller size, oval shape, multiple nodal metastases, and distant metastases. Â The aim of this study was to determine the relationship between EGFR mutations and CT scan images in pulmonary adenocarcinoma patients.Methods: This was a retrospective analytical study consisting of 92 samples, which were categorized into the mutation group (n = 62) and wild group (n = 30). This study was conducted at Dr. Soetomo General Hospital from January 2015 â€“ December 2017. The assessed CT-Scan findings were tumor size, shape, density, lymph node size, pleural effusion, and metastasis presence. The relationship was analyzed using the chi-square test and considered significant if the p-value was < 0.05.Results: This study found a significant relationship between EGFR mutations status with tumor size â‰¤ 3 cm (p = 0.02), lymph node size < 1.5 cm (p = < 0.001) and metastasis (p = 0.026). However, tumor density, tumor form, and pleural effusion did not have significant relationship with EGFR mutation.Conclusion: Tumor size â‰¤ 3 cm, lymph node size < 1.5 cm and presence of metastasis can be found in EGFR mutations pulmonary adenocarcinoma patients.
The different effects of banana juice and sport drink on lactic acid among volleyball students in Surakarta
Authors: Rohmansyah Ryan , Dowes Muchsin , Kristiyanto Agus , Imam Khairul
Published: April 2020

Introduction: The response of lactic acid as a result of exercise in recent times has received considerable attention from physiologists, particularly in term of sports aspect. Lactic acid level is one of the most common measured parameter to determine the performance of athletes. Provision of supplements containing potassium for athletes is usually given such fruit juice or sport drink to prevent muscle fatigue. This study examined the effect of the banana juice and sport drinks to lactic acid in volleyball students.Methods: The study was a randomized experimental trial using pre-post test with control group. The study populations were all volleyball students aged 15-17 years in Pundong Senior High School. The subjects divided into three equal group, 10 subjects in each group treated with either banana juice, sport drink and mineral water as a control group. Sampling was done by a double-blind method.Results: The results of the paired sample T-Test showed a significantly difference of lactic acid levels by intervention with banana juice and sport drink compared to control group with mean difference the mean were 4.43, 3.59, 2.68 respectively (p<0.05).Conclusions: Intervention of banana juice significantly decreased the lactic acid levels compared to sport drinks in volleyball students.
The role of brain-derived neurotrophic factor (BDNF) in cognitive functions
Authors: Silakarma Dedi , Sudewi Anak Agung Raka
Published: April 2020

Nerve growth factor (NGF) was uncovered in near beginning the 1950s which had a growth effect on sympathetic and sensory neurons. In the dorsal root neuron ganglion, the second member of a group of neurotrophic factors widely known as the brain-derived neurotrophic factor (BDNF) appeared. Like other members of the neurotrophin group, such as neurotrophin 3 (NT-3) and NT-4/5, it is explained to have trophic effects on peripheral and central neurons. Since BDNF purification in 1982 evidence of its involvement in development, physiology, and brain pathology demonstrated. BNDF is significant within the molecular mechanism of synapse plasticity regarding neuronal growth and cell survival. The initial step associated with the central nervous system depends on its adaption of synapse transmission, especially in the hippocampus and neocortex. Pathological intensities of the BDNF relationship and synapse plasticity affect sort of situations such as epilepsy and chronic pain sensitization, where BDNF applications can affect therapy in neurodegenerative diseases and neuropsychiatric diseases. BDNF plays a pivotal role in cognitive processes, affecting the advancement and brain structuresâ€™ motion. Predominantly in the hippocampus and prefrontal cortex, by modulating synaptic neurotransmission, it changes the plasticity and proliferation of neurons through regulation of neuronal migration processes such as differentiation, perseveration, neuronal modification and replacement of synaptic structures. BDNF also affects the development of dopaminergic, serotonergic, cholinergic and GABAergic. BDNF further causes rapid postsynaptic reactions in ion channels and N-Methyl D-Aspartate (NMDA) receptors. BDNF as a vital component in the normal functioning of the brain is one of the neurotrophins that contributes to the development, maintenance of function and healthy neuron cells and cynical plasticity.
Electroencephalogram (EEG) features and clinical presentation in the elderly patient at neurologic policlinic Sanglah General Hospital between July 2015-2017 period
Authors: Meidiary Anak Agung Ayu , Gelgel Anna Marita , Putra I Gusti Ngurah Purna
Published: April 2020

Background: Epilepsy has the highest prevalence and many diagnostic process challenges in the elderly population. Research about clinical, type of seizure, and electroencephalogram (EEG) features is very limited in Indonesia, including in Bali. This study aims to know clinical, type of seizure and electroencephalogram (EEG) features in elderly patients.Methods: Cross-sectional descriptive study was conducted among 76 elderly-patients consecutively at Neurologic Policlinic of Sanglah General Hospital Denpasar Bali between July 2015-2017. The clinical aspect, age, gender, and type of seizure were analyzed. Digital electroencephalogram (EEG) was obtained from all patients by 30 minutes of routine EEG recording. Data were analyzed using univariate analysis to determine the frequency distribution of each variable and showed as a percentage in SPSS version 17 for Windows.Results: There were 43 (56,57%) males and 33 (43,43%) females enrolled. Most of the epilepsy in elderly are symptomatic epilepsy which consists of post-stroke epilepsy (30,26%), post-traumatic epilepsy (1,32%), epilepsy-related to brain tumor (10,53%), and post encephalitis epilepsy (6,58%). The type of seizure dominated by partial seizure (57,9%) compared with others.Â  EEG result of 76% of patients was classified as normal EEG, and 24% were abnormal EEG.Conclusion: Most of epilepsy in the elderly are symptomatic epilepsy, and the most cause is post-stroke epilepsy. The partial seizure is the most frequent type of seizure in the elderly.
Cardiorenal syndrome type 1: a literature review
Authors: Rampengan Starry Homenta
Published: April 2020

Kidney Injury is one of the most difficult problems in the first two days of treatment for patients with acute heart failure. Renal dysfunction associated with acute heart failure causes a fairly high morbidity and mortality. This literature review seeks a variety of literature that explains the relationship between kidney damage and acute heart failure and the factors that support these two disturbances. Completion of rapid and prompt diagnosis and treatment from various disciplines of patients with heart failure is important. Investigation is very important to get an early diagnosis, also determine the complications that occur in patients with acute heart failure. New markers such as Kidney Injury Molecule-1 (KIM-1), Neutrophil Gelatinase-Associated Lipocalin (NGAL), L-type FABP (L-FABP) Protein, and Cystatin-C which can be used as acute kidney injury (AKI) patient prognosis.
Relationship between intake of fruits and vegetables toward hypertension among elderly in Yogyakarta
Authors: Ridha Alfan , Hanim Diffah , Suminah Suminah
Published: April 2020

Introduction: Hypertension resembles a medical condition affecting mostly patients over 60 years. Hypertension might be influenced by antioxidant activity and anti-inflammatory components contained in fruits and vegetables. Based on 2013 data, the prevalence of hypertension in the elderly in Indonesia was 25.8%. This study aimed to analyze the relationship between fruit and vegetable intake among geriatric hypertensive patients in the city of Yogyakarta.Methods: Analytical observational study was designed with Cross-sectional type. The subjects of recent study were 138 elderly in integrated service post located in the area of Umbulharjo 1 and Umbulharjo 2 community health center in Yogyakarta City and selected by a multi-stage sampling technique. The consumption of fruits and vegetables measured by Semi-Qualitative food frequency questionnaire (FFQ) and 24-hour recall, meanwhile blood pressure examination used mercury sphygmomanometer.Results: Chi-Square test results showed a relationship between fruits consumed by elderly people and the prevalence of hypertension (p = 0.003) and vegetable intake in elderly significantly associated with the prevalence of hypertension (p = 0.032). The multivariate test results showed there were significant relationship regarding fruit intake with the prevalence of hypertension in elderly (OR = 1.82; p = 0.01).Conclusion: Intake of fruits and vegetables may reduce the risk of hypertension.
Diagnostic test using monofilament compared to electroneuromyography (ENMG) for detection of peripheral neuropathy in leprosy at Sanglah General Hospital, Bali-Indonesia
Authors: Rusyati Luh Made Mas , Sasmita Putu Arie , Adiguna Made Swastika
Published: April 2020

Introduction: Leprosy is a chronic granulomatous infection caused by M. leprae with high affinity to Schwann cell. Primary concern of leprosy is disability due to progressive nerve damage so that patients and their families are sometimes faced with social stigma and discrimination. This can be caused by late detection and treatment of nerve damage. Electroneuromyography (ENMG) as the gold standard for nerve damage detection has limitations in terms of cost and operational procedures, so there is a need for simpler and cheaper method such as monofilament test. This study aims to determine the validity of monofilament test compared to ENMG for the detection of peripheral neuropathy in leprosy.Method: Study design using analytic method with cross-sectional approach, a total 40 patients including paucibacillary and multibacillary type of leprosy who met inclusion and exclusion criteria were recruited by consecutive-sampling. All subjects undergo monofilament test at Dermato-Venereology Clinic of Sanglah General Hospital Denpasar and electroneuromyography test at Neurology Clinic of Sanglah General Hospital Denpasar from December 2018 to February 2019. The data was analyzed to determine sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).Result: The result of this study revealed that monofilament test had an overall sensitivity of 67.2% and specificity of 77.5%. High sensitivity and specificity were found in the sural nerve (85.7% and 75%) and radial nerve (82.7% and 80%)Conclusion: monofilament test can be considered for early detection of peripheral neuropathy, especially for sural and radial nerve.
Three-weeks moderate aerobic exercise in increasing production of endogenous antioxidant enzyme and lowering oxidative stress level among sedentary men
Authors: Griadhi I Putu Adiartha , Mahadewa Tjokorda Gde Bagus , Widyadharma I Putu Eka
Published: April 2020

Background: During exercise, there will be an increase of free radical due to the elevation of oxygen consumption to fulfill the increasing demand for energy. This free radical could produce by muscle and other tissue, especially from the leakage of mitochondria respiratory chain reaction. Moderate exercise training may provide adequate protection against exercise-induced oxidative stress by elevating the antioxidant level and healthier mitochondria that will produce less free radicals. This research will investigate the change of baseline level of MDA and superoxide dismutase (SOD) and also MDA and SOD level after a single bout of moderate exercise before and after three weeks of intervention.Methods: Seven sedentary men with age average 17.2 + 0.2 years recruited for this study. They were meet the criteria of healthy sedentary men. Moderate aerobic exercise of 30 minutes running at 11 â€“ 13 RPE Borg Scale, three times a week for three weeks in a row was applied to the subject. MDA and SOD examination was done by chromatographic assays for total plasma level. The collected data were analyzed using dependent student t-test. Data were normally distributed.Results: The result of this research found a significant elevation of SOD production (p<0.01) after a single bout moderate exercise after three week training (19.98 + 15.52 vs 40.43 +19.64 mg/ml) and significant depression of MDA production (p>0.05) after training program (0.79 + 0.62 vs 1.97 + 0.94 nmol/ml).Conclusion: There is no significant change in post-exercise MDA and SOD level before and after the training program. Initial fitness status, food intake, lifestyle could affect baseline level of MDA and SOD before and after exercise.
Validity and Reliability of the Disaster Preparedness Knowledge Instrument for Health Cadres in Volcanic Disaster-Prone Areas
Authors: Kamaluddin Ridlwan , Trisnantoro Laksono , Alim Syahirul
Published: April 2020

Background: Public health cadres can play an important role in improving disaster response and recovery. However, a multidimensional instrument is needed to assess the levels of disaster knowledge for community health cadres. This instrument is important to develop a complete and effective educational program for disaster preparation for health cadres. Therefore, this study aimed to test validity and reliability of the disaster preparedness knowledge instrument for health cadres in areas prone to volcanic disasters.Methods: A cross-sectional study was conducted by involving 300 respondents. The instrument was developed by conducting literature review followed by completing a qualitative study. We reduced the original instrument from 50 items to a final instrument comprising 41 items, classified into 6 categories: 1) early warning [16 items]; 2) disaster triage [4 items]; 3) basic life support [7 items]; 4) first aid [7 items]; 5) search and rescue [5 items]; and 6) logistic, communications and team organization [2 items].Â  Instrument validation was assessed by using Pearson Product moment and the reliability was estimated by using internal consistency reliability.Results: 300 respondents were involved in this study with all respondents were women aged between 40-49 years old. All of them were either health cadre or high school students. In instrumental testing, all 41 items of the instrument were confirmed through content validity (Pearson Product Moment). Using internal consistency reliability, the study found reasonable inter-item reliability for all items (Cronbachâ€™s Î±: 0.785-0.807).Conclusion: Higher score on disaster triage aspect suggest that health cadres have pivotal role in emergency care during disaster. The finding revealed that disaster triage technique and skills for health cadres or lay man is very important.Â
Factors influencing smoking behavior and intensity of santri in Asrama Perguruan Islam (API) Islamic boarding school, Tegalrejo, Magelang, Central Java, Indonesia
Authors: Wijayanti Punik Mumpuni , Prabandari Yayi Suryo , Ismail Djauhar , Triratnawati Atik
Published: April 2020

Introduction: Tabaco related death is estimated at 6 million people worldwide and it is portrayed to increase to 8 million in 2030. In ASEAN alone, there were approximately 121 million adult smokers in 2013, in which 50% of them were Indonesian. In Indonesia, it is illegal to sell cigarettes to people under 18 years old, but this regulation has weak field implementation and the number of under-age smokers is considerably high in Indonesia. Therefore, this study aimed to analyse the effects of knowledge and perception with smoking intention and behaviour among santris at Asrama Perguruan Islam (API) Islamic boarding school.Methods: A mix method study with sequential explanatory approach was conducted API Islamic boarding school in two phases namely qualitatively and quantitatively. 380 santris were enrolled in this study with interviewees for quantitative study was divided into three groups: santri who < 17 years old, santri who > 17 years old, and housekeepers.Results: The results showed that the knowledge significantly affected the smoking behaviour while had no influence toward smoking intention. On the other hand, no significant association was observed between perceptions with smoking intention while it significantly affected the smoking behaviour.Â Conclusion: It can be concluded that knowledge and perception were importance factors that influence smoking behaviour but had no effects toward smoking intention.
Hemorrhoid artery ligation and recto-anal repair treatment for hemorrhoid: a case series
Authors: Pusparani Christinawati Angelita , Purnomo Sugiharto
Published: April 2020

Introduction: Hemorrhoidal artery ligation (HAL) combined with recto-anal repair (RAR), is an alternative technique for the treatment of hemorrhoid disease from grade I to IV. HAL-RAR involves anoscope with a Doppler to identify the position and depth of rectal arterial, which can be selectively ligated 3-4 cm above the dentate line. This technique has been proposed as a practical, easy to learn, minimally invasive, and safe.Case: 5 cases in Husada Hospital Central of Jakarta with hemorrhoid grade IV underwent HAL-RAR. The initial result, 14th day post-operative follow up, early benefits, and postoperative complications that most affected by HAL-RAR technique will be analyzed. Treatment confirmed 5 cases showed less postoperative pain measured by visual analog scale (VAS), fewer complications, on the 14th day follow up the main complication there was only one case with residual protrusion in initial follow up resolved four weeks later, and well-controlled of manifestation. All patients were satisfied with the result.Conclusion: HAL-RAR is an easy to learn technique, useful to perform, less post-operative pain, and gives fewer complications as treatment of advanced hemorrhoid disease. But, needed more cases and a longer follows up to analyze the late complications and recurrence.
Concomitant injuries in maxillofacial fractures from head and neck division of surgery department at Dr. Sutomo General Hospital, Surabaya, Indonesia in 2015-2016 period
Authors: Wibowo Marjono Dwi
Published: April 2020

Introduction:Â  Maxillofacial fractures were caused most by traffic accidents. This study aims to know about concomitant trauma in maxillofacial fractures.Method: Observational descriptive study to evaluate maxillofacial fracture patients in Head and Neck Division of Surgery Department, Dr Sutomo Hospital between 2015 â€“ 2016.Result: Distribution of maxillofacial fracture patients in 2015 - 2016 based on sex, data on male patients was 77.52%. In 2015 male compared to female 70.5%, increased in 2016 male compared to female 83.82%. The side of fracture found midface fracture 48%, lower face 30.2% and combination mid and lower face 21.7%. Data on maxillofacial trauma with concomitant trauma were 46.5%. Concomitant injury in 2015 was 36.06% and in 2016 as many as 55.88% where there was an increase in cases of concomitant trauma. In 2015 there were 63.63% of the accompanying brain injuries, while in 2016 there were 42.1% brain injuries, where the trauma outside the brain injury also increased.Conclusion: Incidence of concomitant injuries in maxillofacial fractures is 46,5 %, and head injury found 50 % in concomitant injuries. The cause of traffic accidents were motorcycles.Â
Tuberculous peritonitis: a case report
Authors: Aryani Prathita Amanda , Monika Atya Shabrina , Mudianto Mudianto , Brata I Wayan Wisnu
Published: April 2020

Background: Tuberculous peritonitis is a serious condition with rising prevalence in recent years. It is especially common in those patients with risk factors such as an immunocompromised state, chronic kidney disease, cancer, or cirrhosis/liver disease. Spread is typically hematogenous from pulmonary foci.Case Report: We report on a 67-year-old woman who presented with initial complaints of fever and nausea. There is no history of diabetes, tuberculosis and hypertension. An abdominal ultrasound of this patient demonstrating ascites and cholelithiasis emerged. An open cholecystectomy approach to evacuate the gallbladder stones and ascites that occurred in this patient.Conclusion: The biopsy in our patient successfully proved the diagnosis and the patient has undergone an uncomplicated procedure in our facility.
Platelets level response after three days therapy in children with acute Immune Thrombocytopenic Purpura (ITP): a 10 yearsâ€™ experience at the tertiary hospital
Authors: Ariawati Ketut , Setiyawan I Made Karma
Published: April 2020

Background: Immune thrombocytopenic purpura (ITP) is the most common cause of thrombocytopenia in children that characterized by isolated thrombocytopenia that vary in bleeding manifestations. The onset of disease is sudden and a self-limiting condition that requires treatment when clinically significant bleed occurs. A treatment goal is to increase platelet level above safety level and reduce the risk of severe bleeding. This study aims to evaluate the platelets level increment after three days treatment among children with acute ITP.Methods: An analytic retrospective cross-sectional study was conducted in Haematology-Oncology Paediatric Division Sanglah General Hospital, Bali, Indonesia from October 2008 to October 2018 in ITP patients. Diagnosis of ITP was evaluated based on the clinical manifestation and laboratory finding. Oral corticosteroid medication with dosage 2 mg/kg/day or 4 mg/kg/day with or without platelets transfusion were enrolled in this study from medical records. Data were analyzed using SPSS version 20 for Windows.Results: There were 93 children met the inclusion criteria and included in this study. A median platelets level at admission was 6.81(1-86.8) x 109/L. Majority symptoms of children with ITP in our tertiary care centre presented with mild to moderate clinical bleeding symptoms. Only 5.6% children with platelets level below 10x109/L had intracranial bleeding. Median platelets level was 31(2.47-382) x 109/l and there was a significant platelets level increment after three days of therapy (P<0.05).Conclusion: The platelets level increment significantly in children with acute ITP after three days of therapy.
The comparison of fibroblast count and collagen density score in ileal anastomosis with continuous and interrupted suture technique on New Zealand Rabbit
Authors: Fileanugraha Adith , Budipramana Vicky Sumarki , Setiawan Ariandi
Published: April 2020

Introduction: Intestinal anastomosis is carried out with the continuous and simple interrupted sutures technique. Simple interrupted suture is the standard technique in intestinal anastomosis nowadays1,2. Continuous suture has better serosal apposition, shorter processing time and triggers the formation of hypoxia-inducible factor (HIF) which can stimulate the production of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) that stimulate migration and proliferation of mesenchymal cells, especially fibroblast cells which support the synthesis and increasing collagen density in anastomosis tissue. The aim of current study is to compare the anastomosis technique with continuous and simple interrupted sutures reviewed from fibroblast count and collagen density score in rabbit intestines.Method: This study is an experimental study. The sample of this study consisted of 36 rabbits divided into two groups continuous and simple interrupted sutures. Randomization is done by permuted randomization block. The inclusion criteria in this study were rabbit strain Oryctolagus cuniculus aged 8-9 months, weighted 2000-2500 grams, healthy and active. The independent variable in this study is the ileal anastomosis technique and the dependent variable is the fibroblasts count and the collagen density score formed on the anastomosis tissue assessed histopathologically.Results: This study found the average age of the rabbit was 8 months, with an average weight of 2400 grams, the number of fibroblasts in the group of rabbits which received continuous suture was 47 Â± 12.679 fibroblasts per visual field with collagen score was 1.88 Â± 0.781, whereas in rabbits with interrupted sutures, the fibroblasts count was 42.76 Â± 12.47 fibroblasts per visual field with collagen score was 1.82 Â± 0.728. However, from the analytic testing showed that the rabbits treated with continuous suture were not significantly different in fibroblast count and collagen density score compared to simple interrupted group (p>0.05), but in continuous rabbit group have higher collagen density scores and fibroblasts count than rabbits who get simple interrupted sutureConclusion: This study proves that continuous suture results in higher fibroblast count and collagen density score than interrupted suture yet statistically insignificant.
Delayed nerve repair with epineural microsutures in traumatic radial nerve palsy: a case report
Authors: Yanti Ni Luh Putu Julita , Mahadewa Tjokorda Gde Bagus
Published: April 2020

Introduction: Traumatic radial nerve palsy is a condition that need surgical management. Patients who neglect their symptoms or under diagnosed on examination, cause delays to their surgery treatment. Direct nerve repair with epineural microsutures is still the gold standart of surgical treatment for severe axonotmesis and neurotmesis injuries. In this article, we reported a case of nerve repair with epineural microsutures in traumatic radial nerve palsy.Case presentation: A 14-year-old male complained cramps, tingling, and numbness of his left arm and he was unable to extend his left wrist and fingers after he got a left arm injury 3 months ago. The electromyography (EMG) shown that left radial nerve lesion at left radial sulcus. Direct nerve repair is performed by epineural microsutures. Â Two weeks after surgery, we found improvement on the sensory process, but no improvement on the motoric process.Conclusion: Direct nerve repair with epineural microsutures is an effective treatment for radial nerve injury, but the timing for surgery influencing the result of operation.