bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum anti‐GM2 and anti‐GalNAc‐GD1a ganglioside IgG antibodies are biomarkers for immune‐mediated polyneuropathies in cats
Authors: Halstead Susan K. , Jackson Mark , Bianchi Ezio , Rupp Stefan , Granger Nicolas , Menchetti Marika , Galli Greta , Freeman Paul , Kaczmarska Adriana , Bhatti Sofie F. M. , Brocal Josep , José‐López Roberto , Tipold Andrea , Gutierrez Quintana Rodrigo , Ives Edward J. , Liatis Theofanis , Nessler Jasmin , Rusbridge Clare , Willison Hugh J. , Rupp Angie
Published: December 2022

Recent work identified anti‐GM2 and anti‐GalNAc‐GD1a IgG ganglioside antibodies as biomarkers in dogs clinically diagnosed with acute canine polyradiculoneuritis, in turn considered a canine equivalent of Guillain‐Barré syndrome. This study aims to investigate the serum prevalence of similar antibodies in cats clinically diagnosed with immune‐mediated polyneuropathies. The sera from 41 cats clinically diagnosed with immune‐mediated polyneuropathies (IPN), 9 cats with other neurological or neuromuscular disorders (ONM) and 46 neurologically normal cats (CTRL) were examined for the presence of IgG antibodies against glycolipids GM1, GM2, GD1a, GD1b, GalNAc‐GD1a, GA1, SGPG, LM1, galactocerebroside and sulphatide. A total of 29/41 IPN‐cats had either anti‐GM2 or anti‐GalNAc‐GD1a IgG antibodies, with 24/29 cats having both. Direct comparison of anti‐GM2 (sensitivity: 70.7%; specificity: 78.2%) and anti‐GalNAc‐GD1a (sensitivity: 70.7%; specificity: 70.9%) antibodies narrowly showed anti‐GM2 IgG antibodies to be the better marker for identifying IPN‐cats when compared to the combined ONM and CTRL groups (P = .049). Anti‐GA1 and/or anti‐sulphatide IgG antibodies were ubiquitously present across all sample groups, whereas antibodies against GM1, GD1a, GD1b, SGPG, LM1 and galactocerebroside were overall only rarely observed. Anti‐GM2 and anti‐GalNAc‐GD1a IgG antibodies may serve as serum biomarkers for immune‐mediated polyneuropathies in cats, as previously observed in dogs and humans.
Elevated Red Blood Cell Distribution Width Is Associated with Poor Prognosis in Fractured Patients Admitted to Intensive Care Units
Authors: Sun Kaibo , Zhou Yannan , Wu Yuangang , Zeng Yi , Xu Jiawen , Shen Bin
Published: December 2022

Objectives

Red blood cell distribution width (RDW) with prognosis in various infectious diseases. For fractured patients admitted to the intensive care units (ICU), an accurate and fast appraisal is essential. To investigate the association between RDW and prognosis in fractured patients admitted to the ICU utilizing the MIMIC‐III database.

Methods

A retrospective cohort from the MIMIC III database from 2001 and 2012 was constructed. RDW and other information were collected with in‐hospital mortality as the primary outcome and 90‐day mortality and hospital and intensive care unit (ICU) length of stay (LOS) as secondary outcomes. Univariate and multivariate logistic regression models with propensity score inverse probability of treatment weighting (IPTW) were used to investigate the prognostic value of RDW. A nomogram was built with significant prognostic factors to predict in‐hospital mortality, and the performance of the nomogram was evaluated and compared with other severity assessment scores. Subgroup analysis was also conducted.

Results

A total of 2721 fracture patients admitted to the ICU were identified. After IPTW, the group with higher RDW was significantly associated with elevated in‐hospital mortality (odds ratio [OR]: 1.68, 95% confidence interval [CI]: 1.19–2.37), 90‐day mortality (OR: 1.39, 95% CI: 1.04–1.86), prolonged hospital LOS (OR: 1.25, 95% CI: 1.03–1.50), and ICU LOS significantly (OR: 1.26, 95% CI: 1.05–1.53) in the multivariate logistics model. The nomogram showed optimal discriminative ability and predictive accuracy with an area under the receiver operating characteristic curve of 0.77.

Conclusion

RDW independently predicted in‐hospital mortality, 90‐day mortality, and hospital and ICU LOS in fractured patients admitted to ICU. The nomogram including RDW could also be a promising tool with potential clinical benefits.
Chloroplast inner envelope protein FtsH11 is involved in the adjustment of assembly of chloroplast ATP synthase under heat stress
Authors: Yue Xiaohong , Ke Xiangsheng , Shi Yafei , Li Yangsheng , Zhang Chenhao , Wang Yetao , Hou Xin
Published: December 2022

The maintenance of a proton gradient across the thylakoid membrane is an integral aspect of photosynthesis that is mainly established by the splitting of water molecules in photosystem II and plastoquinol oxidation at the cytochrome complex, and it is necessary for the generation of ATP in the last step of photophosphorylation. Although environmental stresses, such as high temperatures, are known to disrupt this fundamental process, only a few studies have explored the molecular mechanisms underlying proton gradient regulation during stress. The present study identified a heat‐sensitive mutant that displays aberrant photosynthesis at high temperatures. This mutation was mapped to AtFtsH11, which encodes an ATP‐dependent AAA‐family metalloprotease. We showed that AtFtsH11 localizes to the chloroplast inner envelope membrane and is capable of degrading the ATP synthase assembly factor BFA3 under heat stress. We posit that this function limits the amount of ATP synthase integrated into the thylakoid membrane to regulate proton efflux from the lumen to the stroma. Our data also suggest that AtFtsH11 is critical in stabilizing photosystem II and cytochrome complexes at high temperatures, and additional studies can further elucidate the specific molecular functions of this critical regulator of photosynthetic thermotolerance.
Comparison of febrile seizures in children with or without coronavirus disease‐2019: A single‐center observational study
Authors: Seo Min Jeong , Yum Mi Sun , Park Jun Sung
Published: December 2022

Background

Febrile seizure (FS) is one of the most common neurological manifestations of coronavirus disease‐2019 (COVID‐19) in children. We compared the clinical characteristics of FS in patients with and without COVID‐19 during the pandemic period.

Methods

This retrospective single‐center study included patients aged 0–18 years who visited the pediatric emergency department (ED) with FS from January 1, 2022, to April 30, 2022.

Results

A total of 186 patients visited the pediatric ED with FS during the study period: 123 (66.1%) were positive for COVID‐19 and 63 (33.9%) were negative. Patients with COVID‐19 were predominantly male (70.7% vs. 50.8%, p = 0.007) and older (2.4 vs. 1.8 years, p = 0.005) than those without COVID‐19. A higher proportion of patients with COVID‐19 were of atypical age (age > 5 years or <6 months) than those without COVID‐19 (26.8% vs. 9.5%, p = 0.006). This was especially true for those aged >5 years (22% vs. 4.8%, p = 0.003). Patients with COVID‐19 had a higher probability of multiple episodes of convulsion within 24 h than those without COVID‐19 (10.6% vs. 1.6%, p = 0.037). Among patients with COVID‐19, males had a shorter fever‐to‐seizure duration than females (3 h vs. 6.5 h, p = 0.045).

Conclusions

Patients with FS with COVID‐19 tend to be predominantly male and have older age of onset than those without COVID‐19. Because of the atypical age of onset and probability of multiple convulsion episodes, vigilance for FS is needed in patients with COVID‐19, especially males.
Armed conflicts and women's authority in intra‐household decision making
Authors: Le Kien , Nguyen My
Published: December 2022

This paper evaluates the extent to which armed conflicts alter women's intra‐household decision making in 51 countries over the past three decades (1990–2018). Exploiting the variations both within and across districts in the timing of battles, we uncover adverse consequences of armed conflict on women's engagement in household decisions on both financial and non‐financial aspects. Specifically, a one standard deviation increase in the number of battles (equivalent to an increase of 5.1 battles) reduces the composite financial and non‐financial decision indices of women by 2.32% and 1.34% relative to the sample averages. Breaking down the decision‐making indices by looking at the underlying items, we further find that the declines in women's intra‐household decision making come from reductions in all aspects of financial and non‐financial domains.
Response of three cereal crops in continuous arable or ley‐arable rotations to fertilizer nitrogen and soil nitrogen at Rothamsted's Woburn Ley‐arable experiment
Authors: Poulton Paul Richard , Johnston Arthur Edward , White Rodger Paul
Published: December 2022

Rothamsted's Woburn Ley‐arable experiment, started in 1938 on a sandy loam soil, provides valuable real‐world data on the effects of all‐arable and ley‐arable rotations. In this study, six rotations were compared from 1973 to 2001. Two had 3‐year arable “treatment” crops, two had 3‐year leys, and two had 8‐year leys; the leys being all‐grass given fertilizer nitrogen (Ln3 and Ln8), or grass/clover (Lc3 and Lc8). Here, we present the yields of two test crops, winter wheat (1981–2000) followed by spring barley (1982–1991) or winter rye (1997–2001) in each of the six rotations, and their response to four rates of fertilizer N and soil N. From fitted yield/N response curves, we show that maximum wheat yields were least (7.10 t ha−1) in the AB rotation, slightly higher, but not significantly so (7.65 t ha−1) following Ln leys but significantly higher (8.12 t ha−1) following Lc leys. Significantly less fertilizer N (30 kg ha−1) was needed to achieve the higher yields following Lc leys. Yields of the second cereal following the leys were 0.3–0.8 t ha−1 higher than those in the AB rotation; these increases were not statistically significant. However, significantly less fertilizer N, 26–38 kg N ha−1, was required to achieve those yields. There was no difference found between the type of ley. The initial benefit of the Lc leys was short‐lived. If leys are to be introduced into mainly arable farming systems, they may need to be subsidized to make them financially viable.
Identification of a novel allele with a frameshift mutation, HLA‐DRB4*01:165N, using next‐generation sequencing
Authors: Hu Qian , Burns Caitlyn , McKinley Connie , Christian Danielle , Berka Noureddine
Published: December 2022

HLA‐DRB4*01:165N exhibits deletion of a nucleotide in exon 3, producing a premature stop codon.
The Frightfully Wrong Essay
Authors: Dugan Elena
Published: December 2022

This teaching note introduces the Frightfully Wrong Essay—a handout prepared by the teacher that is full of leading mistakes. Students compete to catch the most mistakes, establishing and confirming their comprehension of key material from class, while also training critical‐reading practices.
Real‐time fusion of multiple videos and 3D real scenes based on optimal viewpoint selection
Authors: Wang Shunli , Hu Qingwu , Zhao Pengcheng , Yang Honggang , Wu Xuan , Ai Mingyao , Zhang Xujie
Published: December 2022

3D real scenes are a digital virtual space that represents and portrays the real world in a photorealistic, three‐dimensional, and sequential manner. Existing methods for constructing and updating 3D models, such as oblique photography and laser scanning, are difficult to meet the demand of perceiving the real world intuitively, dynamically, and in real time. In recent years, the method of integrating rapidly rising video data and 3D models has become increasingly popular. Compared with existing methods, it enhances the real‐time perception of 3D scenes by taking advantage of the real‐time character of videos and the intuitive character of 3D models. In this article, we propose a real‐time fusion method of multiple videos and 3D real scenes based on optimal viewpoint selection. To begin, 3D reconstruction and video camera calibration were used to prepare the basic data for the fusion of videos and 3D model. Second, a visible‐surface detection‐based video space restoration method was provided, and the overlapping region between multiple videos was determined. Third, to split the overlapping region into the corresponding camera spaces, a segmentation method based on optimal viewpoint selection was given. Finally, the 2D videos were dynamically fitted to the 3D model using the dynamic texture mapping method, while accomplishing the fusing and rendering of the 3D real scene. After experimental verification, the overall effect of the multiple videos and 3D real scene fusion system implemented using the method proposed in this article is better, while the algorithm is less time‐consuming and efficient in rendering.
Neuroinvasive West Nile virus infection in solid organ transplant recipients
Authors: Kasule Sabirah N. , Gupta Simran , Patron Roberto L. , Grill Marie F. , Vikram Holenarasipur R.
Published: December 2022

Background

Literature on the natural course of neuroinvasive West Nile virus (WNV) infection in solid organ transplant (SOT) recipients is sparse. In the setting of a 2021 WNV outbreak in Arizona, we reviewed our institution's experience with neuroinvasive WNV infection in patients with SOT.

Methods

We retrospectively identified SOT recipients treated for neuroinvasive WNV at Mayo Clinic in Arizona from 2007 through 2021. Clinical manifestations, disease course, and outcomes were analyzed.

Results

Among 24 SOT recipients with WNV infection identified during the study period, 13 infections occurred in 2021. Most patients had gastrointestinal tract symptoms and fever at disease presentation. Five patients had cognitive impairment, and 14 initially or eventually had acute flaccid paralysis. Clinically significant deterioration occurred at a median of 4 (range, 1–11) days after hospital admission. Seventeen patients (71%) were transferred to the intensive care unit, with 15 requiring mechanical ventilation. Initial cerebrospinal fluid analysis mainly demonstrated a neutrophil‐predominant pleocytosis. Almost all patients (n = 23) were treated with intravenous immunoglobulin alone or in combination with interferon alfa‐2b. Sixteen patients had clinical improvement, 4 of whom recovered completely. Six patients died during hospitalization due to complications of neuroinvasive WNV infection. Two patients were discharged to hospice without clinical recovery. The overall 30‐day mortality rate was 36%.

Conclusion

Despite advances in supportive care, neuroinvasive WNV infection is associated with substantial morbidity and mortality in SOT recipients. Flaccid paralysis is an indicator of poor prognosis.

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Reassessment Campaign on Veterinary Resuscitation (RECOVER) Initiative small animal CPR registry report 2016–2021
Authors: Hoehne Sabrina N. , Balakrishnan Anusha , Silverstein Deborah C. , Pigott Armi M. , Tart Kelly M. , Rozanski Elizabeth A. , Powell Lisa L. , Boller Manuel ,   Reassessment Campaign on Veterinary Resuscitation (RECOVER) CPR Registry Subcommittee
Published: December 2022

Objective

To introduce the Reassessment Campaign on Veterinary Resuscitation (RECOVER) CPR registry and report cardiopulmonary arrest (CPA) and CPR event data collected to date.

Design

International, multi‐institutional veterinary CPR registry data report.

Setting

Veterinary private practice and university teaching hospitals.

Animals

Data from 514 dogs and 195 cats undergoing CPR entered in the RECOVER CPR registry between February 2016 and November 2021.

Interventions

The RECOVER CPR registry is an online medical database created for standardized collection of hospital, animal, arrest, and outcome information on dogs and cats undergoing CPR. Data were collected according to the veterinary Utstein‐style guidelines for standardized reporting of in‐hospital CPR in dogs and cats. Case records were downloaded, duplicate and incomplete cases were removed, and summary descriptive data were reported.

Measurements and Main Results

Sixteen hospitals in the United States, Europe, and Australia contributed data on 709 CPR events to the registry. One hundred and forty‐two (28%) dogs and 58 (30%) cats attained return of spontaneous circulation (ROSC), 62 (12%) dogs and 25 (13%) cats had ROSC >20 minutes, and 14 (3%) dogs and 4 (2%) cats survived to hospital discharge. The reason for CPR discontinuation was reported as owner choice in 321 cases (63%). The most common suspected causes for CPA were respiratory failure (n = 142, 20%), heart failure (n = 86, 12%), and hemorrhage (n = 76, 11%).

Conclusion

The RECOVER CPR registry contains the first multicenter data set on small animal CPR. It confirms poor outcomes associated with CPA, emphasizing the need for large‐sized studies to gain adequate information on characteristics associated with favorable outcomes.
Successful multimodal treatment of extreme hypertriglyceridemia in a juvenile diabetic dog
Authors: Guarino Aria L. , Cagle Laura A. , Ehrhardt Caryn M. , Beatty Sarah S. K. , Stern Jere K. , Gilor Chen , Specht Andrew J. , Londoño Leo A.
Published: December 2022

Objective

To describe the therapeutic protocol used to normalize severe hypertriglyceridemia in a dog.

Case Summary

A 7‐month‐old, 1.2‐kg female Pomeranian presented with acute polyuria, polydipsia, and ocular discoloration. Diagnoses included diabetic ketosis, severe hypertriglyceridemia (>225 mmol/L [>20,000 mg/dl]), lipemia retinalis, and bilateral uveitis. The triglyceride concentration was near normal within 2 days of initiating treatment with fenofibrate, regular insulin constant rate infusion (CRI), manual therapeutic plasma exchange (TPE), and a low‐fat diet. All clinical signs resolved. The dog has had no relapse of hypertriglyceridemia at the time of writing the manuscript, 6 months later, with continued treatment of diabetes mellitus.

New or Unique Information Provided

This is the first case report documenting the combination of fenofibrate, insulin CRI, and manual TPE for treatment of severe hyperlipidemia in a dog. Detailed protocols for manual TPE and a novel insulin CRI are provided. A discussion of multiple spurious biochemical and hematologic errors associated with the severe hypertriglyceridemia is also provided.
Evaluation of long‐term outcome after lung lobectomy for canine non‐neoplastic pulmonary consolidation via thoracoscopic or thoracoscopic‐assisted surgery in 12 dogs
Authors: Downey Amy C. , Mayhew Philipp D. , Massari Federico , Van Goethem Bart
Published: December 2022

Objective

To report outcomes of thoracoscopic (TL) and thoracoscopic‐assisted lung lobectomy (TAL) for treatment of non‐neoplastic pulmonary consolidation (PC) in dogs.

Study design

Retrospective case series.

Animals

Twelve client‐owned dogs.

Methods

The medical records of 12 dogs that underwent TL or TAL for PC at 3 veterinary institutions between 2011 and 2020 were reviewed. Signalment, history, physical examination, diagnostics, days in hospital, anesthetic and procedure times, intraoperative/postoperative complications, conversion rates, duration of indwelling thoracic drain, and long‐term outcomes were recorded.

Results

Nine patients underwent a TL approach and 3 underwent TAL. In those that underwent TL, conversion to an intercostal thoracotomy was performed in 4 out of 9 dogs. Conversion was performed due to adhesions (n = 3) or poor visualization (1). Histopathologic examination was consistent with pneumonia due to an infectious process (n = 10), bronchioalveolar malformation with abnormal cilia (1), and left‐sided cardiac insufficiency vs. pulmonary alveolar proteinosis (1). The mean duration of hospital stay was 4 days (range, 1‐6 days). Complications occurred postoperatively in 7 dogs and included self‐limiting hemorrhage (n = 3), self‐resolving pneumothorax (2), incisional dehiscence (1), and severe dyspnea in a brachycephalic breed leading to euthanasia (1). For the 11 dogs that survived the perioperative period, there was no evidence of recurrence with a median follow up of 24 months (range, 5‐120 months).

Conclusion

Thoracoscopic (TL) and thoracoscopic‐assisted lung lobectomy (TAL) is a reasonable surgical approach in select dogs with PC.

Clinicial Relevance

Conversion rates were higher than those historically reported for dogs undergoing thoracoscopic lung lobectomy for primary lung tumors.
Fundamentos de ortopedia y traumatología
Authors: Aguilar Sierra Francisco Javier , Arbeláez Echeverri Pablo , Barreto Castilla Ángel Tercero , Briceño Sanín Ignacio , Calvo Carvajal David Santiago , Carrillo Villamizar Nazly Tatiana , Castro Guzmán Francisco Javier , Coronel Pablo José , Cuello Godín Sebastián Enrique , Duplat Lapides José Luis , Fajury Arana Rashid Emilio , Gaitán Lee Hernando , Garavito Goubert Leonardo , García González Luis Alejandro , Gómez Eslava Bárbara , Gómez Gélvez Amparo , González Chávez Raúl Ernesto , Guío Pérez Leyla Susana , Gutiérrez Zúñiga Daniela , Hernández Castro Laura Carolina , Herrera Méndez Frank Mario , Leal Camacho Jaime Andrés , Leal García Efraín , Linares Restrepo Francisco Bernardo , López Hoyos Diana Carolina , Mariño Valero Jaime Benjamín , Martin Viracachá Helbert , Mejía Grueso Alejandro , Montero Silva Carlos Segundo , Olmos Muskus Natalia , Peña Restre Santiago , Pinzón Rendón Andrés Alberto , Ponce de León Samper María Catalina , Posada Murillas Liza María , Quiñonez Yepes Tatiana , Robledo Quijano Jaime , Saíz Guzmán Julián Leonardo , Sánchez Correa Carlos Alberto , Stangl Correa Willy Paul , Suárez Jiménez Luis José María , Taborda Aitken Juan Carlos , Useche Gómez Luis Fernando , Valbuena Bernal Felipe José
Published: December 2022

Fundamentos de ortopedia y traumatología nace en el seno del Departamento de Ortopedia de la Pontificia Universidad Javeriana, gracias a la iniciativa de una estudiante de octavo semestre de Medicina. Su interés fue recuperar el texto como aliado fundamental de las dinámicas estudiantiles en los procesos de enseñanza y aprendizaje de la educación superior y, de esta manera, que aquel sirva como herramienta de consulta para los estudiantes de Medicina, los médicos generales, los ortopedistas en formación, los terapeutas y otros profesionales de la salud que requieran acercarse a esta especialidad.
Deposition of sputtered NiO as a p-type layer for heterojunction diodes with Ga2O3
Authors: Li Jian-Sian , Xia Xinyi , Chiang Chao-Ching , Hays David C. , Gila Brent P. , Craciun Valentin , Ren Fan , Pearton S. J.
Published: December 2022

The characteristics of sputtered NiO for use in pn heterojunctions with Ga2O3 were investigated as a function of sputtering parameters and postdeposition annealing temperature. The oxygen/ nickel and Ni2O3/NiO ratios, as well as the bandgap and resistivity, increased as a function of O2/Ar gas flow ratio. For example, the bandgap increased from 3.7 to 3.9 eV and the resistivity increased from 0.1 to 2.9 Ω cm for the O2/Ar ratio increasing from 1/30 to 1/3. By sharp contrast, the bandgap and Ni2O3/NiO ratio decreased monotonically with postdeposition annealing temperatures up to 600 °C, but the density of films increased due to a higher fraction of NiO being present. Hydrogen is readily incorporated into NiO during exposure to plasmas, as delineated by secondary ion mass spectrometry measurements on deuterated films. The band alignments of NiO films were type II-staggered gaps with both α- and β-Ga2O3. The breakdown voltage of NiO/β-Ga2O3 heterojunction rectifiers was also a strong function of the O2/Ar flow ratio during deposition, with values of 1350 V for 1/3 and 830 V for 1/30.
Acousto-optic holography
Authors: Verburg Samuel A. , Williams Earl G. , Fernandez-Grande Efren
Published: December 2022

Acousto-optic sensing is based on the interaction between sound and light: pressure waves induce density variations, which, in turn, alter the way light propagates in air. Pressure fields are, thus, characterized by measuring changes in light propagation induced by pressure waves. Although acousto-optic sensing provides a way of acquiring acoustic information noninvasively, its widespread application has been hindered by the use of reconstruction methods ill-suited for representing acoustic fields. In this study, an acousto-optic holography method is proposed in which the sound pressure in the near field of a source is captured via acousto-optic sensing. The acousto-optic measurements are expanded into propagating and evanescent waves, as in near-field acoustic holography, making it possible to completely characterize the radiated field noninvasively. An algebraic formulation of the wave expansion enables the use of arbitrary sets of projections. The proposed method is demonstrated experimentally by capturing the acoustic field radiated by a vibrating plate. Accurate holographic reconstructions of the pressure, particle velocity, and intensity fields are obtained using purely optical data. These results are particularly significant for the study of sound fields at mid and high frequencies, where using conventional transducers could perturb the measured field and spatial sampling requirements are challenging.
Erratum to: Several Articles in Doklady Mathematics
Authors: Volkov N. A. , Dmitriev D. I. , Zhukovskii M. E. , Gough J. , Orlov Yu. N. , Sakbaev V. Zh. , Smolyanov O. G. , Bogdanov I. I. , Grigoryan O. R. , Zhukovskii M. E. , Alekseev V. A. , Smetanin Yu. G. , Amaglobeli M. G. , Miasnikov A. G. , Remeslennikov V. N.
Published: December 2022

An Erratum to this paper has been published: https://doi.org/10.1134/S1064562422070018
Erratum to: Several Articles in Doklady Mathematics
Authors: Romanov V. G. , Vedenyapin V. V. , Vasin V. V. , Kovyrkina O. A. , Ostapenko V. V. , Tishkin V. F. , Astashova I. V. , Lashin D. A. , Filinovskiy A. V.
Published: December 2022

An Erratum to this paper has been published: https://doi.org/10.1134/S106456242207002X
Impact of depression on the quality of sleep and immune functions in
patients with coronary artery disease
Authors: Cai Liqiang , Wei Lili , Yao Jiashu , Qin Yanhua , You Yafeng , Xu Luoyi , Tang Jinsong , Chen Wei
Published: December 2022

Background

The risk of major depressive disorder (MDD) and insomnia is higher
in patients with coronary heart disease (CHD) than in the general
population. In addition, immune inflammation may be a shared
aetiological factor for mental disorders and CHD. However, it is unclear
whether MDD is associated with poor sleep quality and cell-mediated
immune function in patients with CHD.

Aims

This study investigated the impact of depression on sleep quality
and cell-mediated immune functions in patients with CHD and examined
discriminative factors in patients with CHD with and without
MDD.

Methods

This cross-sectional retrospective study was conducted at the
Zhejiang University School of Medicine affiliated with Sir Run Run Shaw
Hospital. The study population consisted of 84 patients with CHD
assigned to two groups based on their Hamilton Depression Rating Scale
(HAMD) score (CHD with MDD (HAMD score of ≥10) vs without MDD).
Subjective sleep quality, systemic inflammatory response and
cell-mediated immune functions were assessed in patients with CHD with
(n=50) and without (n=34) MDD using the Pittsburgh Sleep Quality Index
(PSQI), routine blood tests and flow cytometry. The relationships
between variables were ascertained using Pearson’s product–moment, and
linear discriminant analysis was used to explore the discriminative
factors between groups.

Results

Patients with CHD with MDD had significantly poorer sleep quality
than those without MDD (Z=−6.864, p<0.001). The Systemic Inflammation
Index (SII) and CD4 + /CD8 +
T-cell ratios were higher in patients with CHD with MDD than in those
without MDD (Z=−3.249, p=0.001). Patients with CHD with MDD had fewer
CD3 + CD8 + and CD3
+ T cells (Z=3.422, p=0.001) than those without
MDD (t=2.032, p=0.045). Furthermore, patients with CHD with MDD may be
differentiated from those without MDD using the PSQI, SII and T-cell
levels, as these variables correctly classified the depressed and
non-depressed groups with an accuracy of 96.4%.

Conclusions

MDD may be responsible for poor sleep quality, increased
cell-mediated immunity and SII in patients with CHD, which are
discriminative factors for CHD in the depressive state. Clinicians
should be aware of these interactions, as treatment for depressive
symptoms may also improve CHD prognosis.
A simple protocol for anisotropic generalization of Finch–Skea model by gravitational decoupling satisfying vanishing complexity factor condition
Authors: Maurya S. K. , Errehymy Abdelghani , Jasim M. K. , Hansraj Sudan , Al-Harbi Nuha , Abdel-Aty Abdel-Haleem
Published: December 2022

A physically reasonable anisotropic stellar model is constructed with the help of the gravitational decoupling via complete geometric deformation (CGD) technique under the condition of vanishing complexity factor [Contreras and Stuchlik in Eur Phys J C 82:706 2022; Herrera, in Phys Rev D 97:044010, 2018]. The source splits into a perfect fluid and an anisotropic distribution. The Finch Skea metric proves a useful seed solution to solve the Einstein sector while the condition of vanishing complexity is invoked to solve the remaining anisotropic system of equations. A comprehensive battery of tests for physical significance is imposed on the model. Through a careful choice of parameter space, it is demonstrated that the model is regular, stable, and contains a surface of vanishing pressure establishing its boundary. Matching with the exterior metric is also achieved. Finally, the energy flows between the two sectors of the source fluid are studied graphically.
On commutator-based linearization of vector-spinor nonlinear supersymmetry and Rarita–Schwinger fields
Authors: Tsuda Motomu
Published: December 2022

In this paper, we discuss the linearization of vector-spinor (spin-3/2) nonlinear supersymmetry (vsNLSUSY) transformations for both [Formula: see text] and [Formula: see text]-extended SUSY in flat spacetime based on the commutator algebra by using functionals (composites) of spin-3/2 Nambu–Goldstone (NG) fermions, which are expressed as simple products of powers of the spin-3/2 NG fermions and a fundamental determinant in the vsNLSUSY theory. We define basic component fields by means of those functionals in a linearized vsSUSY theory including spin-3/2 fields, general auxiliary ones and a [Formula: see text]-term. The general forms of linear (rigid) vsSUSY transformations for the component fields are determined uniquely from the commutator-based linearization procedure. By considering appropriate recombinations of the functionals of the spin-3/2 NG fermions for [Formula: see text] SUSY, we find that variations of the recombinations under the vsNLSUSY transformations include linear spin-1/2 SUSY ones of spin-[Formula: see text] fields with [Formula: see text] gauge invariance. The spinorial gauge invariance of the Rarita–Schwinger action in the linearization process is also discussed together with the [Formula: see text] gauge invariance.
A molecular dynamics simulation-based laser melting behavior analysis for Ti–Al binary alloy
Authors: Wang Lei , Chen Yaru , Xia Xuhui , Zhang Zelin , Wang Tong , Zhang Huan
Published: December 2022

Due to the lack of theoretical basis for the determination of process parameters, there are problems such as incomplete melting and excessive melting in the molten pool for laser processing, which ultimately cause the increase of defects such as air hole and crack. The melting behavior of Ti–Al binary alloy during laser processing is studied on the atomic scale by molecular dynamics simulation. The embedded atom method potential is adopted to establish the melting model of Ti–Al binary alloy. According to the changes of temperature, atomic structure and mean square displacement, the influence of different process parameters on the melting behavior of Ti–Al binary alloy is discussed. The results show that a short temperature drops from initial melting to complete melting. Mean square displacement increases rapidly with the increase of laser time after completely melting. The atoms start to move violently and the atomic structure is completely transformed into other structure. The heating and cooling rate increases with the increase of power. The laser power has little effect on the overall distribution of atoms after completely melting and only affects the variation rate of various physical quantities in melting process. The research results provide a deeper practical and theoretical evidence for the determination and optimization of the 3D printing and laser heat treatment.
Incremental Updates of Generalized Hypertree Decompositions
Authors: Gottlob Georg , Lanzinger Matthias , Longo Davide Mario , Okulmus Cem
Published: December 2022

Structural decomposition methods, such as generalized hypertree decompositions, have been successfully used for solving constraint satisfaction problems (CSPs). As decompositions can be reused to solve CSPs with the same constraint scopes, investing resources in computing good decompositions is beneficial, even though the computation itself is hard. Unfortunately, current methods need to compute a completely new decomposition, even if the scopes change only slightly. In this article, we make the first steps toward solving the problem of updating the decomposition of a CSP
P
so that it becomes a valid decomposition of a new CSP
P
' produced by some modification of
P
. Even though the problem is hard in theory, we propose and implement a framework for effectively updating generalized hypertree decompositions. The experimental evaluation of our algorithm strongly suggests practical applicability.
Nonnegative Matrix Factorization Based on Node Centrality for Community Detection
Authors: Su Sixing , Guan Jiewen , Chen Bilian , Huang Xin
Published: December 2022

Community detection is an important topic in network analysis, and recently many community detection methods have been developed on top of the Nonnegative Matrix Factorization (NMF) technique. Most NMF-based community detection methods only utilize the first-order proximity information in the adjacency matrix, which has some limitations. Besides, many NMF-based community detection methods involve sparse regularizations to promote clearer community memberships. However, in most of these regularizations, different nodes are treated equally, which seems unreasonable. To dismiss the above limitations, this article proposes a community detection method based on node centrality under the framework of NMF. Specifically, we design a new similarity measure which considers the proximity of higher-order neighbors to form a more informative graph regularization mechanism, so as to better refine the detected communities. Besides, we introduce the node centrality and
Gini
impurity to measure the importance of nodes and sparseness of the community memberships, respectively. Then, we propose a novel sparse regularization mechanism which forces nodes with higher node centrality to have smaller
Gini
impurity. Extensive experimental results on a variety of real-world networks show the superior performance of the proposed method over thirteen state-of-the-art methods.
Orthogonally C∗‐Ternary Jordan Homomorphisms and Jordan Derivations: Solution and Stability
Authors: Keshavarz Vahid , Jahedi Sedigheh
Published: December 2022

In this work, by using some orthogonally fixed point theorem, we prove the stability and hyperstability of orthogonally C∗‐ternary Jordan homomorphisms between C∗‐ternary Banach algebras and orthogonally C∗‐ternary Jordan derivations of some functional equation on C∗‐ternary Banach algebras.
Psychological Distress among Pharmacists during Second Wave of Pandemic: A Cross-Sectional Study
Authors: Dhakal Keshav , Nepal Shobhana , Sapkota Pratigya
Published: December 2022

Background. The outbreak of COVID-19 and subsequent lockdown worldwide have shown a psychological impact among healthcare workers. However, data on the psychological impact among community pharmacists are lacking in the Nepalese context. Aim. This study aimed to assess the psychological distress among community pharmacists during COVID-19 pandemic. Settings and Design. A cross-sectional analytical design was adopted to study the psychological distress of pharmacists working in community pharmacies in Bharatpur. Materials and Methods. Purposive sampling method was used to select 172 community pharmacists. The COVID-19 peritraumatic distress index (CPDI) questionnaire adapted from the Shanghai Mental Health Centre was used to measure psychological distress. Statistical Analysis. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 20. Descriptive statistics (mean, standard deviation, percentage) and inferential statistics (chi-square and logistic regression) were used. Results. Out of 172 respondents, 77.9% were severely distressed while 22.1% were mild to moderately distressed due to COVID-19 pandemic. Mean age of the respondents was 27.81 ± 6.35 years. Logistic regression revealed that having education of bachelor and above (AOR = 4.489, 95% CI: 1.747, 11.539), 8 or more working hours (AOR = 7.633, 95% CI: 2.729, 21.352), being unsatisfied with the job (AOR = 11.524, 95% CI: 3.574, 37.158), and having experience of more than 3 years (AOR = 2.857, 95% CI: 1.060, 7.702) were found significantly linked to severe psychological distress among community pharmacists in Bharatpur. Conclusion. All respondents had suffered from some degree of psychological distress due to the pandemic. Our findings reveal the need for psychological intervention to alleviate psychological distress among pharmacists.
Dynamic Behavior Analysis of Stochastic Nonautonomous Logistic Model with Limited Resources and Lévy Jump
Authors: Ma Yonggang , Liu Junmei
Published: December 2022

In this paper, we discuss the dynamic behavior of the nonautonomous stochastic logistic model under the influence of limited resources and Lévy jump. Firstly, by constructing the Lyapunov function and using the Itô formula, we prove the persistence and extinction of the solution of the model in the sense of p‐moment. Secondly, with the help of the Itô‐Lévy formula, we discuss that the zero solution and positive equilibrium solution of the model are almost asymptotically stable under certain conditions. Finally, we verified the correctness of these conclusions through numerical simulation and explained some specific biological significance.
Effects of Dietary Vitamin C on the Growth Performance, Biochemical Parameters, and Antioxidant Activity of Coho Salmon Oncorhynchus kisutch (Walbaum, 1792) Postsmolts
Authors: Xu Cong-mei , Yu Hai-rui , Li Ling-yao , Li Min , Qiu Xiang-yi , Fan Xiao-qian , Fan Yan-lin , Shan Ling-ling
Published: December 2022

Vitamin C (VC) plays an essential role in fish physiological function and normal growth. However, its effects and requirement of coho salmon Oncorhynchus kisutch (Walbaum, 1792) are still unknown. Based on the influences on growth, serum biochemical parameters, and antioxidative ability, an assessment of dietary VC requirement for coho salmon postsmolts (

183.19
±
1.91

 g) was conducted with a ten-week feeding trial. Seven isonitrogenous (45.66% protein) and isolipidic (10.76% lipid) diets were formulated to include graded VC concentrations of 1.8, 10.9, 50.8, 100.5, 197.3, 293.8, and 586.7 mg/kg, respectively. Results showed that VC markedly improved the growth performance indexes and liver VC concentration, enhanced the hepatic and serum antioxidant activities, and increased the contents of serum alkaline phosphatase (AKP) activity, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and total cholesterol (TC) whereas decreased the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) activities, and triglyceride (TG) level. Polynomial analysis showed that the optimal VC levels in the diet of coho salmon postsmolts were 188.10, 190.68, 224.68, 132.83, 156.57, 170.12, 171.00, 185.50, 142.77, and 93.08 mg/kg on the basis of specific growth rate (SGR), feed conversion ratio (FCR), liver VC concentration, catalase (CAT), hepatic superoxide dismutase (SOD) activities, malondialdehyde (MDA) content, and serum total antioxidative capacity (T-AOC), AKP, AST, and ALT activities, respectively. The dietary VC requirement was in the range of 93.08–224.68 mg/kg for optimum growth performance, serum enzyme activities, and antioxidant capacity of coho salmon postsmolts.
Flexural Behavior of Lattice Girder Slabs with Different Connections: Experimental Study
Authors: Yun Yanchun , Jiang Jiafei , Chen Peng
Published: December 2022

Lattice girder slab (LGS) is a precast composite slab that serves as an alternative to conventional concrete‐in‐place (CIP) slabs. The load‐bearing capacity of joints for the LGSs is essential for large‐span slabs with precast constructions, while limited connections could achieve both free‐of‐formwork construction and higher flexural bearing capacity. In order to enhance the flexural behavior of LGSs with free‐of‐formwork joints, the straight bar lapping connection away from the midspan, loop connection, and straight bar lapping connection within keyway for midspan joints were proposed in this study. Seven full‐scale one‐way LGSs with different transverse connections were tested under the four‐point bending tests to investigate the joint behavior. The overall response and failure mode were observed during the test. The load versus midspan deflection, deflected shape, and characteristic load capacity were analyzed and discussed. The study showed that all the slabs’ deformability could reach as high as l/50 without load reduction. The LGS with the straight bar lapping connection in the midspan had the lowest flexural capacity (70% of the capacity for LGS without joints), while the flexural resistance of the slabs with other connections could be increased by 21.4% to 44.6% compared to LGSs with the traditional straight bar lapping connection in the midspan. The LGSs with the connections having keyways had the most significant improvement and could achieve high flexural capacity and 110% of deformability of the LGS without joints. The findings could enrich the connection types for LGSs for construction convenience and mechanical efficiency and further provide reference for the design of the two‐way LGSs.
Benchmarking the Interactions among Green and Sustainable Vendor Selection Attributes
Authors: Agarwal Reema , Agrawal Ankur , Kumar Nitendra , Shah Mohd Asif , Jawla Preeti , Priyan S.
Published: December 2022

The primary motive of each and every organization or company is to sustain, strengthen, upgrade, and improve its position and standard in the highly dynamic, constantly changeable, aggressive, and competitive environment. There is a very urgent requirement to develop a framework for green and sustainable vendor selection in the organizations. The main aim of this research is to explore, identify, examine, and evaluate the important, applicable, green, and sustainable vendor selection attributes and to analyze and determine their interactions or relationships in the area of green and sustainable vendor selection. A total of ten important attributes have been determined through review reports and by the assessments of the group of professionals belonging to various organizations. A questionnaire has been prepared for these ten attributes and feedback was maintained from the judgments of the group of professionals in dairy industries. In this paper, a multicriteria decision-making technique namely interpretive structural modeling is implemented to look over the interactions and connections among various attributes and to put forward a constructional representation or digraph. Matriced Impacts Croise’s Multiplication Appliqúe and Classment inspection is used to identify which attributes are autonomous, dependent, independent, influencing or not influencing, and importance of one criterion over another according to their driving and dependence powers. It is analyzed numerically from this model that the cost attribute is a very remarkable attribute as it exists in the bottom or sixth level and the attributes economic growth, financial capacity, and research ability are at first or topmost level of this model. The interpretive structural modeling hierarchy constructional representation and Matriced Impacts Croise’s Multiplication Appliqúe and Classment inspection will support the company’s owner or decision maker for attaining a best decision.
Value Creation Assessment Tool for Green Buildings: Development and Implementation
Authors: Alattyih Wael , Haider Husnain , Alsohiman Nawaf K.
Published: December 2022

Green buildings are predestined for the sustainability of arid regions. Presently, professionals working on building construction projects have no assessment tool that integrates value creation and associated risks in the development phase to enhance the value created by green buildings. The present study developed and tested a value creation assessment tool to evaluate the total added value and associated risks that can impact the created value by green building design. The tool consisting of 51 performance value drivers and 35 risk factors was tested on three different buildings in Saudi Arabia. Using a questionnaire survey, each of these projects was scored by its value engineering team and weighted mean scores (Wms) as percentages were calculated. The study revealed that the environmental driver was given less importance in the design process with Wms of less than 60% for all three types of buildings, while the functional driver was given higher importance with Wms of 80% or more. All the buildings showed moderate financial risks ranging between 40 and 50% and a higher potential of management risks with scores around 60% or higher. A wide variation between 20 and 60% was observed for operational risks. The study also found that large‐scale buildings are less threatened by financial risks. The developed tool will facilitate the stakeholders and designers in identifying project development contextual issues and provide opportunities to optimise the design and operations to enhance performance efficiency and obtain more value from investment in GB assets during the early stages of development in Saudi Arabia and elsewhere.
The Mechanism of Quercetin in the Treatment of Lung Squamous Cell Carcinoma Based on a Protein-Protein Interaction Network
Authors: Lu Yiping , Zhang Wenfeng , Li Huayao , Liu Cun , Gao Dandan , Zhuang Jing , Liu Ruijuan , Wu Jibiao , Sun Changgang
Published: December 2022

Background. Lung squamous cell carcinoma (LUSC) is characterized by poor prognosis and obvious limitations of therapeutic methods. The molecular target and mechanism of quercetin (QR), a natural anticancer product with extensive pharmacological activities, on lung squamous cell carcinoma is still unclear. Method. The effects of QR on LUSC were examined using cell proliferation, migration, and invasion tests. Key target genes were screened using The Cancer Genome Atlas (TCGA) database, Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) database, STRING website, topology, and prognosis analysis, molecular docking, and other bioinformatics methods for further analysis. Finally, the effects of QR on the expression of key targets in LUSC cells were detected using a cell cycle assay and western blotting. Results. Our study demonstrates that QR not only inhibits the proliferation of LUSC but also affects the invasion and metastasis of LUSC. After downloading and analyzing the TCGA database, 2150 differentially expressed genes were identified. PLK1, CDC20, and BUB1B were identified using enrichment analysis, topological network analysis, cluster analysis, and molecular docking screening. Subsequent experiments showed that QR could interfere with the cell cycle and downregulate the expression of the target gene PLK1 at the protein level. Conclusions. We found that QR not only inhibits the proliferation, migration, and invasion but also blocks the cell cycle progression of LUSC. QR downregulated the expression of the LUSC target gene PLK1 at the protein level.