bluuebunny/crossref_metadata_2025 huggingface dataset:
HyperBench
Authors: Wei Song , Zhang Kun , Tu Bibo
Published: June 2019

Virtualization is becoming increasingly common in data centers due to its various advantages. However, how to choose among different platforms, including both software and hardware, is a considerable challenge. In this context, evaluating the virtualization capabilities of different platforms is critically important. Regrettably, the existing benchmarks are not qualified for meeting this requirement. Different hardware mechanisms and hypervisor designs introduce many different hypervisor-level events, such as transitions between VMs and the hypervisor, two-dimensional page walk, and binary translation. These events are key factors affecting virtualization performance. Existing benchmarks either overlook these changes or are tightly coupled to a particular hypervisor. In this paper, we present HyperBench, a benchmark suite that focuses on the capabilities of different virtualization platforms. Currently, we design 15 hypervisor benchmarks covering CPU, memory, and I/O. The virtualization-sensitive operation in each benchmark triggers hypervisor-level events, which examines the platform's ability in the target area. HyperBench is designed as a custom kernel which can adapt to different hypervisors and architectures. What's more, adding a new benchmark is pretty easy. Finally, we perform a series of experiments on the host machine and several popular hypervisors, such as QEMU, KVM, and Xen, demonstrating that HyperBench is capable of revealing the performance implications of the hardware mechanism and hypervisor design.
Analysis of a Canonical Labeling Algorithm for the Alignment of Correlated Erdos-Rényi Graphs
Authors: Dai Osman Emre , Cullina Daniel , Kiyavash Negar , Grossglauser Matthias
Published: June 2019

Graph alignment in two correlated random graphs refers to the task of identifying the correspondence between vertex sets of the graphs. Recent results have characterized the exact information-theoretic threshold for graph alignment in correlated Erdös-Rényi graphs. However, very little is known about the existence of efficient algorithms to achieve graph alignment without seeds. In this work we identify a region in which a straightforward O(n
11/5
log n)-time canonical labeling algorithm, initially introduced in the context of graph isomorphism, succeeds in aligning correlated Erdos-Rényi graphs. The algorithm has two steps. In the first step, all vertices are labeled by their degrees and a trivial minimum distance alignment (i.e., sorting vertices according to their degrees) matches a fixed number of highest degree vertices in the two graphs. Having identified this subset of vertices, the remaining vertices are matched using a alignment algorithm for bipartite graphs. Finally, we show that the implementation of a variant of this algorithm allows for the efficient alignment of large graphs under limited noise.
A Systematic Review of Thirty-One Assessment Tests to Evaluate Mobility in Older Adults
Authors: Soubra Racha , Chkeir Aly , Novella Jean-Luc
Published: June 2019

Assessments of gait, balance, and transfer in elderly people play a valuable role in maintaining healthy aging and preventing a decline in mobility. Several evaluation tools have been proposed; however, clinicians should select the most accurate ones wisely, based on numerous criteria. This systematic review aims to identify all applicable elderly mobility assessment tests and show their measurement properties with as much detail as possible. Initially, a broad search was performed. Articles were screened based on their titles and abstracts, and only studies published in English were considered. Based on our inclusion and exclusion criteria, 31 assessment tests evaluating the mobility of healthy elderly people were found. Then, further searches were completed to identify the measurement properties of each test. These characteristics include the origin and year of establishment, several practicality factors, and validity. The analysis of our outcomes illustrates the similarities and differences between the identified tests.
Robust and Privacy-Preserving Service Recommendation over Sparse Data in Education
Authors: Chen Xuening , Liu Hanwen , Xu Yanwei , Yan Chao
Published: June 2019

Service recommendation has become one of the most effective approaches to quickly extract insightful information from big educational data. However, the sparsity of educational service quality data (from multiple platforms or parties) used to make service recommendations often leads to few even null recommended results. Moreover, to protect sensitive business information and obey laws, preserving user privacy during the abovementioned multisource data integration process is a very important but challenging requirement. Considering the above challenges, this paper integrates Locality-Sensitive Hashing (LSH) with hybrid Collaborative Filtering (HCF) techniques for robust and privacy-aware data sharing between different platforms involved in the cross-platform service recommendation process. Furthermore, to minimize the “False negative” recommended results incurred by LSH and enhance the success of recommended results, we propose two optimization strategies to reduce the probability that similar neighbours of a target user or similar services of a target service are overlooked by mistake. Finally, we conduct a set of experiments based on a real distributed service quality dataset, i.e., WS-DREAM, to validate the feasibility and advantages of our proposed recommendation approach. The extensive experimental results show that our proposal performs better than three competitive methods in terms of efficiency, accuracy, and successful rate while guaranteeing privacy-preservation.
Properties Investigation of GO/HA/Pt Composite Thin Film
Authors: Alyafei Huda F. S. G. , Fu W. , Zalnezhad E. , Jaber F. , Hamouda A. M. S. , Musharavati F. , Bae S.
Published: June 2019

Hydroxyapatite/graphene oxide/platinum (HA/GO/Pt) nanocomposite was synthesized and electrodeposited on a pure zirconium substrate. The coated zirconium was annealed at 200, 300, 400, and 600°C in vacuum furnace in presence of argon gas. The structure and morphology of the coated samples were characterized. Biocompatibility and wear and corrosion resistances of specimens were examined. The result of corrosion tests shows that the graphene into HA/Pt composites significantly improves their corrosion resistance. The wear tests results of uncoated and coated samples before and after annealing show that coated samples annealed at 300°C had better wear resistance compared with uncoated and coated samples at other temperatures. Furthermore, the biocompatibility test shows that the coatings improved the cell attachment and proliferation compared to the pure zirconium substrate.
Finite‐Time Nonfragile Dissipative Control for Discrete‐Time Neural Networks with Markovian Jumps and Mixed Time‐Delays
Authors: Hou Ling , Chen Dongyan , He Chan
Published: June 2019

This paper considers the stochastic finite‐time dissipative (SFTD) control problem based on nonfragile controller for discrete‐time neural networks (NNS) with Markovian jumps and mixed delays, in which the mode switching phenomenon, is described as Markov chain, and the mixed delays are composed of discrete time‐varying delay and distributed delays. First, by selecting an appropriate Lyapunov‐Krasovskii functional and applying stochastic analysis methods, some parameters‐dependent sufficient conditions for solvability of stochastic finite‐time boundedness are derived. Then, the main results are extended to SFTD control. Furthermore, existence condition of nonfragile controller is derived based on solution of linear matrix inequalities (LMIs). Finally, two numerical examples are employed to show the effectiveness of the obtained methods.
Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1
Authors: Zhang Leilei , Zhang Jie , Ye Zhiwei , Manevich Yefim , Ball Lauren E. , Bethard Jennifer R. , Jiang Yu-Lin , Broome Ann-Marie , Dalton Annamarie C. , Wang Gavin Y. , Townsend Danyelle M. , Tew Kenneth D.
Published: June 2019

ME-344 is a second-generation isoflavone with unusual cytotoxic properties that is in clinical testing in cancer. To identify targets that contribute to its anticancer activity and therapeutic index, we used lung cancer cell lines that are naturally sensitive or resistant to ME-344. Drug-induced apoptosis was linked with enhanced levels of reactive oxygen species and this initiated a nuclear erythroid factor 2-like 2 signaling response, downstream of which, heme oxygenase 1 (HO-1) was also found to be time-dependently inhibited by ME-344. ME-344 specifically bound to, and altered, HO-1 structure and increased HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells. These effects did not occur in either drug-resistant or primary lung fibroblasts with lower HO-1 basal levels. HO-1 was confirmed as a drug target by using surface plasmon resonance technology and through interaction with a clickable ME-344 compound (M2F) and subsequent proteomic analyses, showing direct binding of ME-344 with HO-1. Proteomic analysis showed that clusters of mitochondrial proteins, including voltage-dependent anion-selective channels, were also impacted by ME-344. Human lung cancer biopsies expressed higher levels of Nrf2 and HO-1 compared with normal tissues. Overall, our data show that ME-344 inhibits HO-1 and impacts its mitochondrial translocation. Other mitochondrial proteins are also affected, resulting in interference in tumor cell redox homeostasis and mitochondrial function. These factors contribute to a beneficial therapeutic index and support continued clinical development of ME-344.

Significance:

A novel cytotoxic isoflavone is shown to inhibit heme oxygenase, a desirable yet elusive target that disrupts redox homeostasis causing cell death.
A Private Secretary from Golden Gate: Lin Shumei in Jinmen (Quemoy), Taiwan and Xiamen
Authors: Chan Ying-kit
Published: June 2019

The exponential growth of the population from the founding decades of the Qing Dynasty to the early nineteenth century placed tremendous stress on the local bureaucracies, which increasingly depended on county clerks and runners and the nondegree-holding literati to reduce costs within the Qing Empire. This article investigates the life of Lin Shumei 林樹梅 (1808–1851), a private secretary, or muyou 幕友, from Jinmen who had served in semiofficial capacities in Taiwan and Xiamen, highlighting the kind of opportunities that were available to him in the imperial bureaucracy. By plotting the career trajectory of Lin Shumei, the article shows that the defence, governance and settlement of the frontier regions of the Qing Empire depended more on the expertise of ‘men on the spot’ such as Lin than on policies devised in the imperial and provincial capitals.
Systematics of Agrophaspidium, a new genus of Neotropical Chloropidae (Diptera)
Authors: WHEELER TERRY A. , MLYNAREK JULIA J.
Published: June 2019

Agrophaspidium gen. n. is described for six species: Agrophaspidium flavimana sp. n. (type locality: La Selva, Costa Rica); Agrophaspidium hastatum Duda, 1930, comb. n. (type locality: Suiza de Turrialba, Costa Rica); Agrophaspidium minutum sp. n. (type locality: Gatun Lake, near Colón, Panama); Agrophaspidium monticola sp. n. (type species of genus; type locality: Monteverde, Costa Rica); Agrophaspidium pollinosum sp. n. (type locality: Portachuelo Pass, Venezuela); and Agrophaspidium psilotum sp. n. (type locality: Guanacaste National Park, Costa Rica). Agrophaspidium is distinguished from other Oscinellinae by the combination of an anteromedial-posterolateral arrangement of the vertical bristles, a dorsally flattened scutellum with four elongate marginal projections bearing stout bristles, and characters of the male genitalia (enlarged epandrium, branched surstylus, enlarged and modified cercus). Although the phylogenetic relationships of species within Agrophaspidium are resolved by morphological characters, the generic relationships to other Oscinellinae are unresolved.
A redescription of 'Megalosaurus' hesperis (Dinosauria, Theropoda) from the Inferior Oolite (Bajocian, Middle Jurassic) of Dorset, United Kingdom
Authors: BENSON ROGER B. J.
Published: June 2019

‘Megalosaurus’ hesperis from the Inferior Oolite (Bajocian, Middle Jurassic) of Dorset, UK is redescribed. Several features of ‘M.’ hesperis demonstrate that it is distinct from the lectotype dentary of Megalosaurus: an enlarged, subcircular third alveolus and subcylindrical, anteriorly inclined anterior dentary teeth; an anterior Meckelian foramen located almost directly anterior to the posterior Meckelian foramen; low interdental plates; and a prominent lip bounding the Meckelian groove ventrally, anterior to the Meckelian fossa. Therefore a new genus, Duriavenator, is erected to form the new combination D. hesperis. D. hesperis possesses two autapomorphies of the maxilla: a deep groove on dorsal surface of the jugal process containing numerous pneumatic foramina; and an array of small foramina in the ventral part of the articular surface for the premaxilla. Several features confirm the tetanuran affinities of D. hesperis: a prominent anterior process of the maxilla; the presence of band-like dental enamel wrinkles; the maxillary 'fenestra' is present but takes the form of an imperforate fossa (a spinosauroid synapomorphy); and the paradental groove is wide anteriorly, defining a distinct gap between the interdental plates and the medial wall of the dentary (a synapomorphy of Spinosauridae + Megalosauridae). Older records of tetanurans have been proposed, but most of these have been refuted and detailed re-examination of other early reports is warranted to establish the date of origin of this clade. An early Middle Jurassic origin of tetanurans is preferred.
Pilato, G., Fontoura, P., Lisi, O. & Beasley, C. (2008) New description of Echiniscus scabrospinosus Fontoura, 1982, and description of a new species of Echiniscus (Heterotardigrada) from China. Zootaxa, 1856, 41–54.
Authors: PILATO G. , FONTOURA P. , LISI O. , BEASLEY C.
Published: June 2019

(Erratum)
Morphology and DNA sequences confirm the first Neotropical record for the Holarctic sepsid species Themira leachi (Meigen) (Diptera: Sepsidae)
Authors: ANG YUCHEN , LIM GWYNNE SHIMIN , MEIER RUDOLF
Published: June 2019

Even for the most cosmopolitan of species, climate frequently presents effective barriers for dispersal. For example, many eurytopic and synanthropic species go extinct when introduced into a new climatic zone, and translocated ants remain in sheltered environments reminiscent of their home climate (McGlynn, 1999). Here we report the occurrence of a primarily Holarctic dipteran species, Themira leachi (Meigen), in Neotropical Cuba. This discovery suggests that the species may have a large disjunct distribution, as the next closest record lies almost 3,500 km to the north in Nearctic Newfoundland, Canada (Ozerov, 1998).
A catalogue of the holotypes of chigger mites (Acariformes: Trombiculidae) at the Natural History Museum of Geneva
Authors: STEKOLNIKOV ALEXANDR A.
Published: June 2019

The personal collection of P.H. Vercammen-Grandjean, which is deposited in the Natural History Museum of Geneva (Switzerland), is revised and a catalogue of holotypes is compiled. The inventory includes data on the holotypes of 92 valid trombiculid species, 18 specimens erroneously labeled as holotypes and 84 specimens designated as holotypes of unpublilshed species (nomina nuda).
Rapid Cyclogenesis from a Mesoscale Frontal Wave on an Atmospheric River: Impacts on Forecast Skill and Predictability during Atmospheric River Landfall
Authors: Martin Andrew C. , Ralph F. Martin , Wilson Anna , DeHaan Laurel , Kawzenuk Brian
Published: June 2019

Mesoscale frontal waves have the potential to modify the hydrometeorological impacts of atmospheric rivers (ARs). The small scale and rapid growth of these waves pose significant forecast challenges. We examined a frontal wave that developed a secondary cyclone during the landfall of an extreme AR in Northern California. We document rapid changes in significant storm features including integrated vapor transport and precipitation and connect these to high forecast uncertainty at 1–4-days’ lead time. We also analyze the skill of the Global Ensemble Forecast System in predicting secondary cyclogenesis and relate secondary cyclogenesis prediction skill to forecasts of AR intensity, AR duration, and upslope water vapor flux in the orographic controlling layer. Leveraging a measure of reference accuracy designed for cyclogenesis, we found forecasts were only able to skillfully predict secondary cyclogenesis for lead times less than 36 h. Forecast skill in predicting the large-scale pressure pattern and integrated vapor transport was lost by 96-h lead time. For lead times longer than 36 h, the failure to predict secondary cyclogenesis led to significant uncertainty in forecast AR intensity and to long bias in AR forecast duration. Failure to forecast a warm front associated with the secondary cyclone at lead times less than 36 h caused large overprediction of upslope water vapor flux, an important indicator of orographic precipitation forcing. This study highlights the need to identify offshore mesoscale frontal waves in real time and to characterize the forecast uncertainty inherent in these events when creating hydrometeorological forecasts.
Future research demands of the United European Gastroenterology (UEG) and its member societies
Authors: Enck Paul , Meisner Søren , Figueiredo Ceu , Mayerle Julia , Ricciardiello Luigi ,   the UEG Research Committee
Published: June 2019

Aims

The purpose of this study was to initiate and stimulate collaborative research efforts to support United European Gastroenterology Federation (UEG) member societies facilitating digestive health research in European on the one hand and, on the other hand, to increase EU‐funded digestive health research by providing evidence and advice to funding bodies on priority areas. The UEG Research Committee initiated a survey of the current and future research interests of each individual UEG ordinary member society (specialist societies).

Methods

A questionnaire was sent by mail to 17 UEG ordinary member societies asking them to specify research demands related to the most urgent medical need including basic science research, translational research, clinical research, patient management research and research on disease prevention, in an open fashion but with limited word count.

Results

The responses from 13 societies were analysed in a semi‐quantitative and in a qualitative way, and were clustered into five domains with two aspects each that were consented and shared between three and seven of the responding 13 societies. These clusters resemble topics such as ‘Hot topics’ (e.g. life‐style, nutrition, microbial‐host interaction), Biomarkers (genetic profiling, gut‐brain interaction), Advanced technology (artificial intelligence, personalised medicine), Global research tools (bio‐banking, EU trials), and Medical training (education, prevention).

Conclusion

The generated topic list allows both collaboration between individual specialist societies as well as initiating and fostering future research calls at the EU level and beyond when approaching stakeholders.
Rethinking the camp: On spatial technologies of power and resistance
Authors: Martin Diana , Minca Claudio , Katz Irit
Published: June 2019

In light of the recent proliferation and co-presence of institutional and makeshift camps and encampments in Europe, this article explores the current multifaceted geographies of the camp and their formal and informal spatialities. By engaging with key work in ‘camp studies’ we analyse contemporary institutional and makeshift refugee camps in their complex relationship. While the review of the existing literature is a fundamental starting point for our analysis, in this article we propose to depart from a perspective exclusively focussed on institutional camps to incorporate a reflection on the informal encampments that have recently proliferated in Europe. In particular, we reflect on how these makeshift spatial formations are associated with the presence and workings of institutional camps, at times in a complementary, almost symbiotic relationship. We conclude by suggesting that camps should not be studied in isolation and that both institutional and informal camps should be examined as dynamic spaces that may be transformed and appropriated by their residents, becoming part of the current fragmented mobilities of irregular migrations across Europe and of the related political geographies of bordering, smuggling, and humanitarian care.
Development of smart city community service integrated management platform
Authors: Qi Lei , Guo Jing
Published: June 2019

With the acceleration of the construction of smart city in China, the construction of a smart community that acts as the last mile of a smart city is highly valued. Development of smart community service integrated management platform is to utilize intelligent equipment and software platform, to build an information platform for information sharing, service integration, and resource optimization, and to ultimately realize intelligent management and innovative services within the community. In this article, we propose the overall framework and application system of the intelligent community integrated service platform, providing a strong theoretical basis for the construction of smart communities at this stage, and carry out detailed analysis and design of the underlying infrastructure, supporting platform and basic database of the platform.
An efficient crowd-sourcing-based approach for fingerprint database updating
Authors: Liu Xi , Cen Jian , Zhan Yiju , Tang Chengpei
Published: June 2019

Fingerprint-based indoor localization has become one of the most attractive and promising techniques; however, one primary concern for this technology to be fully practical is to maintain the fingerprint database to combat harsh indoor environmental dynamics, especially in the large-scale and long-term deployment. In this article, focusing on three key problems now existing in fingerprint database updating approaches such as the mechanism for triggering updates, the collection of new fingerprints and determination of fingerprints’ location information, we propose a fuzzy map mechanism and decision methods of neighbours’ fingerprints in response to all kinds of changes in indoor environments. Meanwhile, we design a static data collecting mechanism to filter reliable information from numerous users’ inputs and propose a neighbours’ fingerprint-assisted technique to calculate the location of fingerprints. Experimental results demonstrate that the proposed solution not only improves the performance of updating the fingerprint database in real time and robustness by 40% and 50%, respectively, but also reduces the update frequency and improves mean location accuracy by over 40%.
Development of textile-based transmission lines using conductive yarns and ultrasonic welding technology for e-textile applications
Authors: Atalay Ozgur , Kalaoglu Fatma , Kursun Bahadir Senem
Published: June 2019

The development of the conductive transmission lines is crucial part for the creation of wearable electronic systems. The current focus of this study is to create signal transmission lines resistant to environmental effects. To do this, an ultrasonic welding technology has been used in order to analyze its suitability for e-textile transmission line manufacturing. Two groups of yarns, namely, stainless steel yarns and silver-plated yarns were used along with polyester fabrics. The used yarns were also varied according to their linear density and electrical conductivity. Based on the experimental results, while stainless steel yarns were merely affected in terms of conductivity change, silver-plated yarns found to be less suitable for ultrasonic welding technology. However, silver-plated yarns with higher linear density showed satisfactory results at moderate working conditions.
Safety of vedolizumab in liver transplant recipients: A systematic review
Authors: Spadaccini Marco , Aghemo Alessio , Caprioli Flavio , Lleo Ana , Invernizzi Federica , Danese Silvio , Donato Maria F
Published: June 2019

Background

The management of inflammatory bowel disease in patients who have previously undergone liver transplantation can be a clinical challenge. There are serious concerns among physicians regarding the use of biologics for treating such immuno‐compromised patients.

Objective

We performed a systematic review on vedolizumab therapy in transplant recipients to assess its safety.

Methods

PubMed/Embase/Scopus were searched up to November 2018 to identify papers regarding liver transplant recipients and therapy with vedolizumab. Primary outcomes were adverse events. Secondary outcomes were liver transplant and inflammatory bowel disease outcomes.

Results

Eight studies (31 patients) were included. Nine out of 31 patients experienced an infection within a mean follow‐up time ranging from 5–20 months. No malignancies were reported. Inflammatory bowel disease clinical response was experienced by 20/26 patients. Abnormalities in liver tests were recorded in 2/22 patients.

Conclusion

Vedolizumab may be considered safe for treating inflammatory bowel disease in liver transplant recipients. Caution is recommended for patients with an unstable liver graft function.
Early‐onset versus late‐onset Crohn’s disease: An Italian cohort study
Authors: Cantoro Laura , Lenti Marco Vincenzo , Monterubbianesi Rita , Cicala Michele , Giannarelli Diana , Papi Claudio , Kohn Anna , Di Sabatino Antonio
Published: June 2019

Background

Disease heterogeneity, according to the age at onset, has been reported in Crohn’s disease (CD).

Objective

This study aimed to compare natural history in CD patients diagnosed ≤17 (early onset (EO)) versus ≥60 (late onset (LO)) years old.

Methods

EO CD and LO CD patients referred to two Italian inflammatory bowel disease (IBD) centres were included. Relevant data comprised sex, current smoking, disease location and behaviour, IBD family history, extra‐intestinal manifestations and use of medical/surgical therapy during the follow‐up period.

Results

Among 2321 CD patients, 160 met the inclusion criteria: 92 in the EO and 68 in the LO group (mean follow‐up 11.7 ± 7.7 years). Family history of IBD was more frequent in EO compared to LO CD (26% vs. 4%; p  < 0.0001). Ileocolonic, upper gastrointestinal and perianal involvement occurred more frequently in EO compared to LO CD (56% vs. 21%, p  < 0.0001; 17% vs. 3%, p  < 0.01; and 38% vs. 19%, p  < 0.01, respectively). Progression to complicated disease occurred more frequently in EO CD (40% vs. 10% p  < 0.005), with an increased use of corticosteroids and anti‐tumour necrosis factor alpha agents within 10 years since diagnosis (81% vs. 58%, p  = 0.004, and 36% vs. 16%, p  = 0.01, respectively), while the cumulative probability of surgery did not differ between the two groups.

Conclusions

Patients with EO CD are more likely to develop a more aggressive disease with perianal involvement and a greater use of drug treatment compared to those with LO CD, without carrying an increased need for surgery.
Identification of five hub genes as monitoring biomarkers
for breast cancer metastasis in silico
Authors: Cai Yun , Mei Jie , Xiao Zhuang , Xu Bujie , Jiang Xiaozheng , Zhang Yongjie , Zhu Yichao
Published: June 2019

Background

Breast cancer is one of the most common endocrine cancers among
females worldwide. Distant metastasis of breast cancer is causing an increasing
number of breast cancer-related deaths. However, the potential mechanisms of
metastasis and candidate biomarkers remain to be further explored.

Results

The gene expression profiles of GSE102484 were downloaded from the
Gene Expression Omnibus (GEO) database. Weighted gene co-expression network
analysis (WGCNA) was used to screen for the most potent gene modules associated
with the metastatic risk of breast cancer, and a total of 12 modules were
identified based on the analysis. In the most significant module
(R2 = 0.68), 21 network hub genes (MM > 0.90) were
retained for further analyses. Next, protein-protein interaction (PPI) networks
were used to further explore the biomarkers with the most interactions in gene
modules. According to the PPI networks, five hub genes (TPX2, KIF2C, CDCA8, BUB1B, and CCNA2) were identified as key genes associated with breast cancer
progression. Furthermore, the prognostic value and differential expression of
these genes were validated based on data from The Cancer Genome Atlas (TCGA) and
Kaplan-Meier (KM) Plotter. Receiver operating characteristic (ROC) curve analysis
revealed that the mRNA expression levels of these five hub genes showed excellent
diagnostic value for breast cancer and adjacent tissues. Moreover, these five hub
genes were significantly associated with worse distant metastasis-free survival
(DMFS) in the patient cohort based on KM Plotter.

Conclusion

Five hub genes (TPX2, KIF2C, CDCA8,
BUB1B, and CCNA2) associated with the risk of distant metastasis were extracted
for further research, which might be used as biomarkers to predict distant
metastasis of breast cancer.
The psychosis risk timeline: can we improve our preventive strategies? Part 3: primary common pathways and preventive strategies
Authors: Romain Karen , Eriksson Alexandra , Onyon Richard , Kumar Manoj
Published: June 2019

Psychosis is a recognised feature of several psychiatric disorders and it causes patients significant distress and morbidity. It is therefore important to keep knowledge of possible risk factors for psychosis up to date and to have an overview model on which further learning can be structured. This article concludes a three-part series. It gives a review of evidence regarding common pathways by which many risk factors come together to influence the development of psychosis and finalises our suggested overview model, a psychosis risk timeline. The three primary pathways considered are based on the major themes identified in this narrative review of recent literature and they focus on neurological, neurochemical and inflammatory changes. We link each back to the factors discussed in the first and second parts of this series that alter psychosis risk through different mechanisms and at different stages throughout life. We then consider and summarise key aspects of this complex topic with the aim of providing current and future clinicians with a model on which to build their knowledge and begin to access and understand current psychosis research and implications for future preventive work.

LEARNING OBJECTIVES

After reading this article you will be able to:

•

give an overview of common pathways thought to link identified risk factors with psychosis development

•

understand neurochemical, neurostructural and inflammatory changes associated with psychosis

•

demonstrate increased knowledge of possible preventive strategies.

DECLARATION OF INTEREST

None.
Stereotactic body radio therapy for inoperable large hepatocellular cancers: results from a clinical audit
Authors: Chopra Supriya , George Karishma , Engineer Reena , Rajamanickam Karthick , Nojin Siji , Joshi Kishore , Swamidas Jamema , Shetty Nitin , Patkar Shraddha , Patil Prachi , Ostwal Vikas , Mehta Shaesta , Goel Mahesh
Published: June 2019

Objectives:

To evaluate the outcomes of stereotactic radiotherapy (SBRT) in the treatment of inoperable hepatocellular carcinomas (HCC) that are unsuitable for, or refractory to other liver-directed therapies.

Methods:

Between March 2015 and June 2018, patients with primary HCCs refractory to or unsuitable for treatment with other liver-directed therapies were treated with SBRT. Patients of Child status A5-B7 and with normal liver reserve ≥ 700 cc were preferred. Local control (LC), overall survival (OS), progression free survival (PFS) and effect of prognostic factors were analysed.

Results:

21 patients with inoperable HCCs were treated. The median tumour diameter was 9.6 cm (5-21) and median tumour volume was 350 cc (32.9 – 2541). The median SBRT dose prescription was 42 Gy/6 fractions (25 – 54 Gy/6#). The 1- and 2-year LC rate was 88 and 43 % respectively. Overall rate of > grade III toxicity was 14 %. Patients with Child A5 liver function had a better median OS than A6 and B7 patients [21 vs 11 vs 8 months]. Also, tumours with GTV < 350 cc volumes had a better OS compared to GTV of greater than 350 cc [24 months vs 8 months, p value = 0.004].

Conclusions:

This study showed that SBRT can be used safely and effectively to treat inoperable HCCs with or without prior loco-regional therapies, resulting in good local control and survival with acceptable toxicity.

Advances in knowledge:

Use of SBRT in inoperable HCC is safe and effective.
Sensitive and quantitative probing of pseudouridine modification in mRNA and long noncoding RNA
Authors: Zhang Wen , Eckwahl Matthew J. , Zhou Katherine I. , Pan Tao
Published: June 2019

Pseudouridine (Ψ) is the most abundant RNA modification in cellular RNA present in tRNA/rRNA/snRNA and also in mRNA and long noncoding RNA (lncRNA). Elucidation of Ψ function in mRNA/lncRNA requires mapping and quantitative assessment of its modification fraction at single-base resolution. The most widely used Ψ mapping method for mRNA/lncRNA relies on its reaction with N-Cyclohexyl-N′-(2-morpholinoethyl)carbodiimide (CMC), forming an adduct with the Ψ base in RNA that is detectable by reverse transcription (RT) stops. However, this method has not produced consistent Ψ maps in mRNAs; furthermore, available protocols do not lend confidence to the estimation of Ψ fraction at specific sites, which is a crucial parameter for investigating the biological relevance of mRNA modifications. Here we develop a quantitative RT-PCR based method that can detect and quantify the modification fraction of target Ψ sites in mRNA/lncRNA, termed CMC-RT and ligation assisted PCR analysis of Ψ modification (CLAP). The method still relies on RT stop at a CMC-Ψ site, but uses site-specific ligation and PCR to generate two distinct PCR products in the same sample, corresponding to the modified and unmodified site, that are visualized by gel electrophoresis. CLAP not only requires a small amount of cellular RNA to validate Ψ sites but also determines the Ψ fraction semiquantitatively at target sites in mRNA/lncRNA. We determined the Ψ status of four mRNA sites and one lncRNA site whose modification fractions range from 30% to 84% in three human cell lines. Our method enables precise mapping and assessment of Ψ modification levels in low abundance cellular RNAs.
Visualization of drug target interactions in the contexts of pathways and networks with ReactomeFIViz
Authors: Blucher Aurora S. , McWeeney Shannon K. , Stein Lincoln , Wu Guanming
Published: June 2019

The precision medicine paradigm is centered on therapies targeted to particular molecular entities that will elicit an anticipated and controlled therapeutic response. However, genetic alterations in the drug targets themselves or in genes whose products interact with the targets can affect how well a drug actually works for an individual patient. To better understand the effects of targeted therapies in patients, we need software tools capable of simultaneously visualizing patient-specific variations and drug targets in their biological context. This context can be provided using pathways, which are process-oriented representations of biological reactions, or biological networks, which represent pathway-spanning interactions among genes, proteins, and other biological entities. To address this need, we have recently enhanced the Reactome Cytoscape app, ReactomeFIViz, to assist researchers in visualizing and modeling drug and target interactions. ReactomeFIViz integrates drug-target interaction information with high quality manually curated pathways and a genome-wide human functional interaction network. Both the pathways and the functional interaction network are provided by Reactome, the most comprehensive open source biological pathway knowledgebase. We describe several examples demonstrating the application of these new features to the visualization of drugs in the contexts of pathways and networks. Complementing previous features in ReactomeFIViz, these new features enable researchers to ask focused questions about targeted therapies, such as drug sensitivity for patients with different mutation profiles, using a pathway or network perspective.
Modern Means of Communication and Their Impact on the Social, Cultural and Intellectual Development of a Child
Authors: Колома Хосе , Koloma Hose , Гарсия Дебора , Garsiya Debora
Published: June 2019

The article of American colleagues reveals the role of modern means of communication in the process of training and education of children of primary school and adolescence. Primary attention is paid to video games, the characteristics of their different types, including educational orientation. With concrete examples, the possible positive effect of the use of video games by teachers for the intellectual development of students, as well as the risks of uncontrolled use by children, are considered. Recommendations are given to teachers and parents to control the play activities of younger schoolchildren and adolescents in order to prevent the negative impact of video games on the health and mental state of a child.
Event-Marketing As a Key Tool of the Complex Progress in the Service Sector
Authors: Резник Галина , Reznik Galina , Соколкова Т. , Sokolkova T.
Published: June 2019

Introduction: the article deals with the essence of event-marketing as a popular tool for promotion in the market, the place of event-marketing in the complex of marketing communications is determined. A study on the development of the Park of culture and recreation “Olympic” based on the use of event-marketing tools is carried out. The results of the study of existing tools to promote the Park are given, the motives and preferences of potential guests of the Park on the basis of a survey are identified, recommendations for its development are given. Materials and methods: the article uses the publications of well-known scientists, methods of abstract-logical, systematic, economic and statistical, comparative analysis, graphic, methods of sociological and marketing research (in the survey of consumers of the Park of culture and recreation “Olympic”). The results of the study: the analysis of existing ways to promote the services of the Park of culture and recreation “Olympic” showed that the Park is not enough and not often held various event-events. In addition, the events are not diverse, which indicates the lack of use of event-marketing tools in the Park. In this regard, a variety of events was offered, within the framework of the implementation of such areas as sport events, exhibitions and art creativity, leisure activities for young people, romantic events, catering, opening and restoration of the existing Playground, modernization of the roller rink and art cafe, opening of the Park of extreme species, improvement of the Park and the opening of the school with clubs for the implementation of creative directions. Discussion and conclusion: Improvement program Park development using the tools of event marketing will contribute to the implementation of the Federal program “Formation of a comfortable urban environment for 2018–2022.g.”, to increase the customer traffic, to improve the visitor traffic, average check, increase the quality of life of the population. For organizations in the sphere of communication services, Event-marketing is the most effective direction of direct communication and is one of the most popular and progressively developing tools.
Digital Assets As Economic Factor: Competitiveness, Opportunities and Limits of Legal Regulation
Authors: Арямов А. , Aryamov A. , Грачева Ю. , Grachyeva Y. , Чучаев А. , Chuchaev A. , Руева Е. , Rueva E. , Маликов С. , Malikov S.
Published: June 2019

In this article, the authors in the prism of determining the limits of legal regulation of digital assets analyzed the specifics of participation of digital assets in commodity-money relations, identified the risks of economic turnover of cryptocurrency (as a digital resource) and developed proposals for hedging such risks.
Toxoplasma gondii – the facts
Authors: Castro Pablo David Jimenez , Dubey Jitender P
Published: June 2019

The protozoan parasite Toxoplasma gondii was initially isolated from the rodent Ctenodactylus gundi, and it has been found worldwide from Alaska to Australia with nearly one third of the human population having been exposed to this parasite. All warm-blooded hosts, including humans, can be infected by any one of its three infective stages: tachyzoites, bradyzoites, and sporozoites. Felids are the definitive hosts of this intracellular pathogen. Although it usually causes mild disease or asymptomatic infection in immunocompetent adults, this parasite can cause devastating disease in congenitally infected children and those with depressed immunity. Because of its zoonotic potential, toxoplasmosis triggers the interest of the diverse medical and veterinary specialities. Consciousness needs to be increased that this disease can produce clinical cases not only in immunocompromised patients or through vertical transmission, but also in healthy patients. In this article, we will review the biology and the epidemiology of this parasite.
Best practice parasite prevention in the travelling pet
Authors: Wright Ian
Published: June 2019

The number of pets travelling under PETS is increasing year on year, while at the same time, climate change and increased movement of people is affecting parasite distribution across Europe and the wider world. Accurate parasite prevention advice to clients taking their pets abroad is therefore vital to keep pets and owners safe. It is also an important aspect of UK biosecurity and the prevention of exotic parasites and vectors establishing. Although it is the role of the Official Veterinarians (OV) to issue passports and ensure legal pet travel requirements are followed, nurses also play a pivotal role in discussing parasite risks with clients and ensure accurate up to date preventative advice is given. This article summarises the risks posed by some of the major parasites and vectors across Europe and effective practical prevention advice to give to clients.
An investigation of the prevalence of compassion fatigue, compassion satisfaction and burnout in those working in animal-related occupations using the Professional Quality of Life (ProQoL) Scale
Authors: Scotney Rebekah L , McLaughlin Deidre , Keates Helen L
Published: June 2019

Background:

Animal-related occupational stress and compassion fatigue are important issues as they can have a negative impact on employee mental wellbeing, workplace productivity and morale. The impacts of these conditions are notable and have become more recognised by those who are employed in animal-related occupations.

Aims:

This study aims to investigate the incidence of compassion satisfaction and compassion fatigue (burnout and secondary traumatic stress) in those working in animal-related occupations using the Professional Quality of Life (ProQoL) Scale.

Methods:

Data were collected from 229 employees from a range of animal-related occupations using an anonymous self-report survey.

Results:

Most respondents were employed in veterinary practice (either veterinarians or veterinary nurses/technicians) and 85% of all respondents were female. 42% of participants were between 26 and 35 years of age and, 71% had been working in animal-related occupations between 1 and 10 years. Most participants scored in the mean or top quartile on the compassion satisfaction scale; however, about a quarter reported a score which indicated that they were deriving less satisfaction from their work. Low burnout was reported by 78% of participants; however, 21% of participants had a score which indicated that they were at higher risk of burnout. Low or average symptoms of secondary traumatic stress was reported by 74% of participants; however, 25.8% were at risk of secondary traumatic stress. While most of the surveyed population scored in the mean or top quartile on the compassion satisfaction scale, all of the occupational categories reported experiencing the negative aspects of caring: burnout and secondary traumatic stress.

Conclusion:

The prevalence of compassion fatigue demonstrated in these results should be a major concern in animal-related occupations and thus, be used as a beneficial, contextualised resource to inform resilience training programmes and preventative strategies specifically targeted towards those working in animal-related occupations.
556. La inversión directa de España en México en la era del neoliberalismo económico. Dinámica temporal, estructura sectorial y distribución geográfica
Authors: Sánchez Salazar María Teresa , Alonso Santos José Luis , Casado Izquierdo José María
Published: June 2019

A partir de los cambios estructurales implementados en la economía mexicana durante los decenios 1980-1990, México se convirtió en destino preferencial de la inversión española en Latinoamérica pero su comportamiento mostró diferencias notorias durante el periodo 1993-2013. La investigación examina con detalle, primeramente, la evolución de la inversión directa de España en México desagregada por ramas económicas de destino en tres fases que marcan momentos clave en la evolución reciente de la economía española y la relaciona con las reformas estructurales realizadas en la economía mexicana. En la segunda parte, la investigación profundiza en la distribución geográfica de dichas inversiones en las entidades federativas de México, identificando procesos de concentración espacial y diferenciando la intensidad y las ramas económicas de inversión según su destino geográfico. Se resalta el papel protagónico del capital y las empresas españolas en México en ramas específicas y la tendencia a su expansión futura.
560. Estrategias de renovación de barrios industriales en ciudades medias españolas. La experiencia de León
Authors: Benito del Pozo Paz , Diez Vizcaíno Franciso
Published: June 2019

Análisis de la transformación de barrios industriales en ciudades medias españolas a partir del caso de León, en el norte peninsular. El objetivo se centra en las estrategias e instrumentos de los agentes públicos para sustituir los usos y funciones tradicionales por otros relacionados con la nueva economía y competitividad urbana. Con enfoque histórico se revisa la formación del llamado León Oeste, una zona donde las fábricas y el ferrocarril impulsaron el cambio urbano en la etapa del industrialismo. La crisis del modelo fordista desencadenó la desindustrialización de este barrio, un reto para la planificación urbana y un negocio para los agentes implicados en la producción de suelo. Como solución, se plantean intervenciones urbanísticas que responden al doble fin de crear focos de centralidad alternativos y oportunidades que dependen de la especialización terciaria y de la alta velocidad ferroviaria, opciones no exentas de riesgos y que tienen como trasfondo la burbuja inmobiliaria que lastra el proceso de urbanización español desde 2008.