bluuebunny/crossref_metadata_2025 huggingface dataset:
SOCIAL - EMOTIONAL COMPETENCE OF STUDENTS WITH HEARING LOSS IN HUE CITY
Authors: Mai Thi Thanh Thuy
Published: April 2022

Children with hearing loss are at risk of having difficulties in developing social-emotional competences compared to their peers. In Vietnam, so far, there has been no research on the social-emotional competence of hearing-impairedchildren. This paper aims to evaluate the reliability of the DASSE mini scale in using it to assess the social-emotional competence of children with hearing loss. This study used SPSS.20 software to evaluate the reliability and exploratory factor analysis (EFA) of the scale. A cross-sectional study on assessing social-emotional competence with the DASSE mini scale was conducted on 50 hearing-impaired students aged 6-12 years with varying degrees of impairment. The results of the evaluation of predictive validity show that the scale has high reliability and has good and suitable predictive value: Cronbach's Alpha = 0.928, KMO = 0.869 (> 0.05), sig. = 0.000 (sig Bartlett's Test < 0.05). The average score of the DASSE mini scale is: Mean =16.67. There are 56% of the students with social-emotional competence scores in the range of "Typical scores" and 44% with scores of "Need for instruction". There was no significant difference between male and female students in the study (t(50) = .377, p > .05), but the results showed annegative correlation between one’s degree of hearing loss and their social-emotional competence (r = -549, sig < .005).
THE ORIGINS OF CHAMPA: WAS THERE A KINGDOM OF XI-TU (西屠國) IN THE THU BỒN VALLEY ?
Authors: Vo Van Thang
Published: April 2022

There is a theory that explains the origins of Campā (Champa) by rendering a paradigm in which a kingdom referred to as Xi-Tu emerged in the Thu Bồn valley (a part of Quảng Nam Province today in central Việt Nam) around the 3rd century CE, and then absorbed the Lin-Yi kingdom by the end of the 6th century, resulting in what today is known as Champa. In contrast to this assumption, this paper uses both historical and archeological evidence to show that there was, in fact, no such a kingdom in the Thu Bồn valley in the 6th century. Instead, the evidence shows that from the beginning of the 4th century Lin-Yi conquered many small neighbouring kingdoms, including Xi-Tu (if it in fact existed). Champa, or Campā, was the Sanskrit name used by the ruling class of the Kingdom of Lin-Yi to refer to their territory (Lin-Yi is the name derived from Chinese historical documents). The discussions concerning the existence of Xi-Tu aim to clarify the nature of the birth of the polity with Indic influences located on the coast of Indochina,known as Champa. Determining the cradle of Champa, once known to be in the territory of Lin- Yi, could lead to a better understanding of the growth of this kingdom, with its unique historical and geographical background. With this in mind, the author would like to share his views on the issue, currently regarded as "a critical point in the historiography of Champa" (Taylor, 2021, 581).
GENDER AND MARKET: A SOCIOLOGICAL ANALYSIS OF COMPARISON BETWEEN TRADITIONAL MARKET AND SHOPPING MALL
Authors: Verma Aayushi , Misra Pawan Kumar
Published: April 2022

This investigation attempts to discover the factors liable for various purchasing conduct of customers of traditional market (tribal market and rural market) and shopping centre and how sexual orientation assumes a significant part in the buyers purchasing motives and decisions. This paper takes into account an assortment of factors that keep on affecting the purchasing motives and decisions with changing marketplaces and with respect to gender contrasts. It investigates how sexual orientation in different aspects are associated with market be it as a consumer or in workforce. The paper likewise examines, how even the items and brands are gendered. This study further investigates shopping propensities in different types of markets in India and endeavours to recognize and differentiate potential contrasts between genders utilizing various studies. The paper attempts to analyse various previous investigations regarding two unique sorts of market and tried to understand consuming behaviour of patrons on these two types of markets.
The Impact of the Relation Between Movement Patterns and Nodes Distribution on the Performance of Smart Cities
Authors: Wadullah Wael
Published: April 2022

In smart cities, it is believed that there exists an impact of the relation between the movement patterns of mobile nodes from one side, and their distribution from the other side, on the overall performance of the smart city. This work tries to investigate this kind of relation using simulations. To this end, experiments were designed using a variety of parameters. Different distributions were used as well as a mobility model with a routing protocol. Four kinds of experiments were designed, each of which includes different settings. The simulations were carried out and the results were obtained and then analyzed. The performance and the stability of these experiments were investigated. The results showed interesting facts about the simulations. The results of this research can be of benefit to smart city researchers. It will also be of interest when it comes to developing optimal strategies for spreading advertising in a smart environment.
Depression Disorder Detection Using Facial Expression and Text Mining on Recorded Social Media Videos
Authors: Prof. Chaudhari B. S.  , Aarju Ashpak Atar  , Priya Vijay Shinde  , Apeksha Ajay Bhosale  , Shweta Jaywant Agam
Published: April 2022

Suicide is one of the most serious public health problems in modern culture. Thoughts of suicide, also known as suicidal thoughts, refer to people's suicidal plans. It can be used as a suicide risk measure. India is one of the top countries in the world with an annual suicide rate. Social networks have been developed as a first way to measure its users to connect with their interested friends and to rate their captions, photos, and videos that express their feelings, feelings and emotions. Enlarge and intensify the version that takes the form of facial images such as inserts and symbols. On the basis of what it predicts the patient's reputation whether or not he or she has not been diagnosed due to depression. We can train the translation using pictures and we will use it to predict. Image caption can be completed after predicting to get a higher visibility of the report. We will also use the text mining process (NLP) to predict the melancholy use of symbols provided with human assistance. Finally we are able to make the final choice primarily based on the two strategies above. Generate a detailed dashboard of user status and design webpage for an advanced program. We will use CNN's algorithm to accelerate the detection of depressed characters and how to know about high-quality responses to mental health problems. We propose a system learning approach as an effective and measurable method. We are writing the implementation of the proposed approach. We evaluated the effectiveness of our proposed approach to the use of a set of different aspects of mental language. We demonstrate that our proposed approach can significantly improve the accuracy and pricing of class errors.
Computer Lab Automation using IoT
Authors: Prof. Vinod Alone  , Vighnesh U. Paradkar  , Vishwas V. Jadhav  , Aditya G. Jadhav
Published: April 2022

The Internet of Things (IoT) is the fastest growing computing technology integration that conceives the primary objective of associating real world objects with the internet. In the process of creating a smart lab, this method can be absorbed to make a lab automated. This paper bases on building an automated PC lab. Understanding the pros and cons of the IoT technology such that the harmful effects like are minimized and benefits are increased makes up a relevant point in building the model. This paper has been written with keeping the rate of growth of automation products/industries and with this the project is made.
Implementation of Smart Stick for Blind People
Authors: Dr. P. N. Yerkewar  , Ms. Diksha Vaidya  , Ms. Nikita Bandhekar  , Ms. Ragini Jadhao  , Ms. Vaishnavi Nile
Published: April 2022

Visually disabled people have to face many challenges in their daily life and problem gets worst when there is an obstacle in their way. People find difficulties detecting obstacles in front of them, during walking on the street, which makes it harmful, so the stick is basically designed for blind people for easy navigation. In this project we propose a solution, we indicate clearly in a smart stick with ultrasonic sensor to detect stairs or pair of ultrasonic sensor to detect any other obstacles in front of the user, within a range of 1-1.5 meters. In addition, moisture sensor is placed at the middle of the stick for detecting water and puddles mostly in rainy season. When any obstacle is detected then buzzer beeps. This proposed system uses the microcontroller Arduino nano embedded system, buzzer, GSM, GPS, encoder IC, decoder IC, pcb. The stick is able to detect all obstacles in the range 10-15 meters during 39 ms. the visually impared people can walk independently in unfamiliar environment .In this project we are going to use GSM module which is interfaced with GPS device therefore the care taker or relative receive the intimation message with location at their mobile phone in case of any emergency. The smart blind stick is of low cost, fast response, easy to design light weight.
Electric Vehicle Charging Station Design by Using NI-LAB View
Authors: Dileep Kumar  , Shrirang Gandhi  , Rahool Singh  , Smriti Kumari  , Prof. S. R. Desai
Published: April 2022

Global environmental concerns & rising energy demand, along with ongoing advancements in renewable energy technology, are creating new prospects for renewable energy consumption. Solar energy is perhaps the most plentiful, in- exhaustible, and environmentally friendly form of renewable energy currently available. Global warming has accelerated the development of Electric Vehicles (EVs), which look to be the greatest alternative to internal combustion engines (IC engines). Due to the rising number of electric cars on the road, charging them through the traditional fossil fuel-based grid is neither cost-effective or efficient. Thus, a charging station powered by renewable energy offers enormous possibilities & control for electric car charging. A charging station for electric vehicles that integrates solar energy or a storage battery (BEES) has been built for the present circumstances. To provide continuous electricity at the charging station, additional grid assistance is contemplated without adding to the system’s strain. Taking into account the dynamic charging requirements of EVs, the charging station design is developed and evaluated using the LAB VIEW programme.
International application of the “Multidimensional Intervention for Social Anxiety” (MISA) program: II. Treatment effectiveness for social anxiety-related problems
Authors: Salazar Isabel , Caballo Vicente , Arias Víctor , Curtiss Joshua , Rossitto Alicia , Gómez Araujo Rosa , Herrera Puente Juan , Coello María , Gamarra Olivia , Sanguino Andrés Rosa , Hofmann Stefan , del Moral Bernal Susana , Herrera Giner Paula , Royuela Ángel
Published: April 2022

In a previous work (Caballo et al., 2021) we tested the effectiveness of the Multidimensional Intervention for Social Anxiety (MISA) program in reducing social anxiety symptoms. In this quasi-experimental study, with pre/post-treatment and follow-up measures, we examined the impact of the MISA program on other problems related to social anxiety. 57 people diagnosed with social anxiety disorder (SAD), according to DSM-5, were assessed with a diagnostic interview and questionnaires measuring social skills, depression, avoidant personality disorder symptoms, alcoholism, self-esteem, personal sensitivity, worries, and quality of life. Different therapists carried out the treatment in Ecuador, Spain, and Paraguay. The results showed significant improvements at post-treatment in virtually all measures assessing the above variables, improvements that were maintained at six months. Effect sizes on treatment effectiveness ranged from medium to large. The MISA program was also compared with individual cognitive behavioral therapy and pharmacological treatment, with favorable results for the MISA program. In conclusion, this new program for the treatment of social anxiety has a significant impact on other problems usually related to SAD.
Cuestionario de percepción de factores causales de la Covid-19 (CPFC-Covid-19)
Authors: Prieto Andreu Joel Manuel
Published: April 2022

En el artículo se detalla el procedimiento de validación de un cuestionario que analiza la percepción de los factores causales de la pandemia de la COVID-19, el CPFC-COVID-19. Se realizó una prueba piloto con 55 sujetos, se analizó la validez de contenido y de comprensión a través del juicio de 8 expertos y la validez de constructo a través de un análisis factorial exploratorio. Además, se realizó un análisis factorial confirmatorio con una muestra de 427 personas, se calculó la validez convergente y se hizo un análisis descriptivo y de consistencia interna de los factores del cuestionario final. El CPFC-COVID-19 quedó constituido por 20 ítems y cuatro dimensiones: Distanciamiento social y Protección (DSP), Impacto psicológico percibido (IPP), Escepticismo (E) y Credibilidad de la información percibida (CIP). Los resultados demuestran la validez del cuestionario y unos altos índices de fiabilidad, lo que permite conocer las percepciones de la población acerca de los factores causales de la COVID-19.
Validación del “Cuestionario de aceptación y acción laboral” (WAAQ) con estudiantes universitarios
Authors: Ponce María , Villar Esperanza
Published: April 2022

El objetivo de este estudio fue adaptar y validar el “Cuestionario de aceptación y acción laboral” (WAAQ; Bond et al., 2013) para que pueda ser utilizado para medir la flexibilidad psicológica en el ámbito académico de una universidad del Ecuador. La muestra de estudio estuvo compuesta por 6.230 estudiantes. El instrumento demostró una alta consistencia interna (α= 0,90; ω= 0,91). El análisis de los componentes principales mostró un solo factor, lo que explica el 62,3% de la varianza. El análisis factorial confirmatorio mostró un ajuste satisfactorio del modelo. Las correlaciones entre el WAAQ y el “Cuestionario de aceptación y acción-II” (AAQ-II, Bond et al., 2011) y la “Escala de competencia personal de Wallston” (Wallston, 1992) sugieren que los cuestionarios evalúan diferentes constructos. Se concluyó que el WAAQ es un instrumento válido y fiable para medir la flexibilidad psicológica en el ámbito académico universitario ecuatoriano.
FEATURES OF INTERACTIVE MUSEUMS OF SCIENCE: A VIEW THROUGH THE PRISM OF ORGANIZATIONAL AND PEDAGOGICAL IDEAS OF YAKOV PERELMAN
Authors: Savchenko Ya. V. , Slipukhina I. А.
Published: April 2022

The development of a child's creative potential is an important component of scientific education. Its formation is directly related to curiosity and is best stimulated through play, design, art and speech activities. The formation of the concept of interactive museums of science plays a significant role in the development of students’ creative potential. We considered the organizational and pedagogical features of the House of Interesting Science for Children, created in the 30s of the twentieth century by the Soviet scientific and technical team led by the world-famous popularizer of science Ya. Perelman. The main factors and prerequisites for the success of museums are identified and characterized, such as high scientific level of exhibits, their technical and scientific quality and interactivity, use of heuristic methods, demonstration of unexpected effects in natural phenomena, scaling ideology of science education, dissemination of experience competitions, contests, various events that can be a source of new creative ideas, the formation of quality publications that create conditions for further independent research and stimulate visits to museum spaces. The House of Interesting Science, created under the leadership of Ya. Perelman, can also be considered the first startup with a healthy marketing model. The key approaches to the creation of such innovative spaces of scientific education, which are based on the stimulation of curiosity and independent research activities, are identified. Forming the creative potential of students is one of the tasks of the Small Academy of Sciences of Ukraine, which created the Museum of Science - the first interactive space, which was prepared on the basis of thorough retrospective and comparative studies of relevant experience.
Analisis Strategi Untuk Pengembangan Usaha Usaha Mikro Kecil dan Menengah di Gresik Jawa Timur
Authors: Syaifudin Arif
Published: April 2022

Judging from the business competition in the snack food sector in Gresik, there are a lot of snack businesses that are open, causing intense competition. In addition, there are consumer tastes that are constantly changing and want healthy snacks with good quality and affordable prices so that UD. Nur Rohmah is required to provide something different from other snacks so that consumers can be loyal. The research was conducted with the aim of describing the strategies that have been implemented, to analyze the internal and external environment and to develop alternative business development strategies. The research was conducted at UD. Nur Rohmah Replaces Gresik. Data were collected through observation, document analysis, and interviews using the snowball sampling technique. The data analysis method was carried out using the SWOT analysis method (Strengths, Weaknesses, Opportunities and Threats). The results showed that by implementing a market development strategy using SWOT UD. Nur Rohmah has more customers and can open new branches to expand its market share in accordance with his vision.

Keyword: MSMEs, Business Environment, SWOT Analysis, Business Development Strategies
Determination of Distribution Channel Marketing and Service Innovation Quality in Increasing Consumer Satisfaction
Authors: Amiruddin Yudistira Putra , Modding Basri
Published: April 2022

In determining the distribution as an entrepreneur, he must select the distribution channel in his business, and one of them is using the Shopee digital application, creating a page on Facebook, and many other digital accesses that can be used; the aim is to reach more potential customers to see the products being sold, making it easier for prospective customers to see. Customers can contact us online and make transactions easier for customers and entrepreneurs. This research aims to determine the role of distribution channel marketing in increasing customer satisfaction. To find out how service innovation quality increases customer satisfaction. Mapping article use 20 of manuscript form scopus databased index. The proposition in this mapping are H1: Distribution channel marketing has a positive and significant effect on increasing consumer satisfaction. H2: Service innovation quality has a positive and significant effect on increasing customer satisfaction.H3: The distributor channel marketing variable has the most significant influence on increasing consumer satisfaction.
Theory of Planned Behaviour in Marketing: Cognitive Consideration on Purchase Decision
Authors: Sari Ovi Hamidah
Published: April 2022

The desire to search for products sequentially is dominated by the gifts or rewards offered and the costs of searching for a product itself. A person's cognitive ability will affect when they stop searching for a product until they decide to buy without remembering. Advances in computerized technology that are more intensive, like today's purchase decisions, will be faster and better. Cognitive intelligence and preferences as well as long-term memory in superior decision making, if applied, will successfully avoid negative purchase decision results, where consumers who have good numeracy skills will produce more explicit mental representations; this process can be necessary for superior decision making. Resume of prior research in this study use 13 of manuscript form scopus databased index in year 2017 - 2021. The proposition in this mapping is Correlation  Theory  of  planned  behavior  theory in  the  aspect  of  the  field  of management  (e.g.,  marketing,  Technology, Marketing, E-Commerce)  make  a  positive  contribution  as  a grounded theory to explain the variable antecedent and also its correlation to other theories.
Sarawak Traditional Dance Motion Analysis and Comparison using Microsoft Kinect V2
Authors: Gau Michael-Lian , Ting Huong Yong , Ting Jackie Tiew-Wei , Peter Marcella , Ibrahim Khairunnisa
Published: April 2022

This research project aimed to develop a software program or an interactive dance motion analysis application that utilizes modern technology to preserve and maintain the Sarawak traditional dance culture. The software program employs the Microsoft Kinect V2 to collect the digital dance data. The proposed method analyses the collected dance data for comparison purposes only. The comparison process was executed by displaying a traditional dance on the screen where the user who wants to learn the traditional dance can follow it and obtain results on how similar the dance is compared to the recorded dance data. The comparison of the performed and recorded dance data was visualized in graph form. The comparison graph showed that the Microsoft Kinect V2 sensors were capable of comparing the dance motion but with minor glitches in detecting the joint orientation. Using better depth sensors would make the comparison more accurate and less likely to have problems with figuring out how the joints move.
Thyrotropin/Thyroglobulin ratio in combination with thyroid u/s to assess malignancy risk stratification of thyroid nodules
Authors: Abotaha Ahmed Ahmed , El mancy Ismail Mohmed , Tealeb Sayed Mohamed , Khedr Gamal , Ramadan Ibrahim Ghoneim , Badr Gamal Ali
Published: April 2022

Objective: we aimed to asses if thyrotropin/thyroglobulin ratio has a significant value in detection of malignant thyroid nodules. Design: Retrospective analysis. Material and Methods: This study included finally 100 subject collected as outpatient’s endocrinology clinic of ALHuessine university hospital or admitted at oncology institute of Tanta. Patients who had history of thyroid diseases or surgery, those with abnormal levels of anti- thyroglobulin antibodies, cases without simultaneous measurement of serum anti Tg., with history of current use of thyroid hormone replacement therapy were excluded from this study. Clinico pathological features, as well as serumTSH, Tg, and TSH/Tg were compared between histopathologically benign and malignant groups. Results: Data related to 100 subjects (40%) normal  and 60(60%) patients  with thyroid nodules were analyzed, 30 patients (50%) were malignant thyroid nodules and 30 patients (50%) were benign.The malignant patients exhibited significantly higher TSH, TSH/Tg, , and a lower Tg compared to the benign patients (p<0.05 for each). Conclusion: Preoperative TSH/Tg could be used as a predictive marker for differ-entiating between benign and malignant thyroid nodules.
Knowledge, attitude, practice on different matrix systems used for class 2 composite restorations among dental students
Authors: Kumaran Thiru , Antony S. Delphine Priscilla
Published: April 2022

Introduction: A matrix is defined as a properly contoured piece of metal or other contoured piece of metal or other material used to support and give form to material used to support and give form to the restoration during its placement and restoration during its placement and hardening. Characteristics of a good matrix  are rigidity, establishment of proper anatomical contour,restoration of correct proximal contact relation, easy adaptation to the tooth, easy adaptation to the tooth,ability to be contoured,prevention of gingival excess, strength to offer resistance to condensation pressure and  easy removal from the tooth. Aim: To check the knowledge and practice of different matrix systems in class 2 composite restoration. Materials and Methods: Self administrated questionnaire was designed based on matrix systems for class 2 composite restoration. The questionnaire was distributed through an online survey link. The questionnaire was completed by 100 participants, and the data were analysed using SPSS software. Descriptive statistics and Pearson Chi square test were done to analyze the results of the survey. Majority of the participants are aware of the different matrix system for class 2 composite restoration.
Nosocomial infections in surgical intensive care unit
Authors: Singh Pramod , Chatterjee Tushar Kanti , Saha Saikat
Published: April 2022

Background: Various microorganisms predominant in hospitals causes nosocomial infections (NIs) making patients in Surgical intensive care units (SICU) prone to NI. Aim: To study the prevalence, antibiotic and microbiological sensitivity, and resistance profiles, as well as the influence of NI in ICU, stay and mortality in patients admitted to our hospital's SICU. Materials and Methods:Over a period of a year, a retrospective investigation of all surgical ICU patients was performed. All patients who suffered withNIwere included in the study. The incidence of NI, their sites, and the bacteria that cause them have all been recognized. The grown bacteria's antibiotic sensitivity pattern was discovered. By comparing this group of patients with NIto a group of patients without NI in terms of age, gender, and clinical diagnosis, the impact of NIon ICU duration and death was assessed. Results:During the trial, 80 of the 235 patients who were admitted to ICU developed NIand were selected. The control group consisted of 80 patients who matched the research group's participants. In our research, 34.04% of patients had NI. The most prevalent nosocomial infection was skin and soft tissue infections (37.89%), which included surgical wound infections, followed by respiratory infections (24.21%) and genitourinary infections (22.11%).
Study the CAT-21 A/T (rs7943316) gene polymorphism and its correlation with physiological antioxidant index in the Iraqi patients with T2DM
Authors: Hamzah Elham F. , Sharhan Abbas A. , Hadi Suhad J. , Kzar Hamzah H. , Maktouf Ali H.
Published: April 2022

Background: A multi-gene inherited metabolic illness in which the body is unable to produce enough insulin and is characterized by abnormal glucose homeostasis has been now called Type 2 diabetes mellitus (T2DM). Objectives: This study aimed to evaluate the effect of CAT-21 A/T (rs7943316) gene polymorphism and antioxidant index (AOI) in the Iraqi patients with T2DM. Methods: In general, 135 individuals, 90 T2DM patients and 45 healthy control were employed in this research. The spectrophotometer method were used to assessment of  TAO-C and MDA levels (antioxidant index TAO-C/MDA), while CAT-21 A/T (rs7943316) SNPs was an estimate by PCR-RFLP and restriction fragments by Hinf1 enzyme restriction.  Results: In this study, the results propose profoundly tremendous contrasts in TAO-C, MDA, and AOI levels among T2DM and the benchmark group (p-value< 0.05). Then again, the outcomes propose the profoundly bad relationship (r=-0.765) between the periods of the T2DM bunch with TAO-C as well as, we tracked down an exceptionally certain connection (r=0.556) between the times of the T2DM bunch with MDA levels. Furthermore, in the genetic part of this work, the results indicated that the AA homozygote genotype implied a statistically significant effect (P-value=0.000) (OR=2.66(1.23-4.12)) for the risk of T2DM.
N-acetyl-cysteine effect on total antioxidant capacity in Iraqi men with oligoasthenoteratozoospermia
Authors: Salman Fatima Sinan , Al-Qadhi Huda I. , Alkareem Baraa A.
Published: April 2022

The aim of this prospective study is to evaluate the effect of using N-acetyl cysteine (600mg/day) for 3 consecutive months on the serum level of total antioxidant capacity of Iraqi males with idiopathic infertility. This study was performed at infertile center of ALKUT hospital during the period from October 2021 to March 2022 .A total 45 patients with idiopathic oligoasthenoteratozoospermia were received N-acetyl cysteine (NAC) for 12 weeks, their total antioxidant capacity (TAC) was measured at the baseline and after 12 weeks. The results showed that TAC levels were significantly higher (0.61±0.02 vs. 0.86±0.02 ; LSD= 0.10 ) which confirmed that NAC has positive effect in increasing the level of antioxidant capacity in infertile men and thus decreasing the reactive oxygen species ROS and restore the oxidant balance level resulting in better spermatogenesis and sperm function.
Role of optical coherence tomography angiography in early detection of retinal microvascular changes in adolescents with type 1 diabetes
Authors: Shamma Radwa A. , Hosni Yomna A. , Hassan Mona M. , Hassan Nihal A. , Khedr Dina
Published: April 2022

Purpose: Early detection of diabetic retinopathy can prevent progressive visual loss. Evaluate the role of Optical Coherence Tomography Angiography (OCTA) in early detection of diabetic retinopathy (DR) in type 1 diabetes (T1D) adolescents with normal fundus photography. Methods: Cross-sectional study included 150 eyes of 75 T1D adolescents from the Diabetes Endocrine and Metabolism Pediatric Unit, Children hospital, Cairo University. Their ages ranged from 10-18 years and diabetes duration 2 years or more. Fundus photography, OCT and OCTA were done in the diagnostic and laser unit, Ophthalmology department. Results: Twenty-eight patients (37.3%) had abnormalities in the OCTA despite normal fundus examination, photography and OCT. Diabetes duration, DKA at presentation and frequency, elevated blood pressure, limited joint mobility, elevated HbA1c and dyslipidemia had a negative correlation with OCTA measurements (foveal, parafoveal and perifoveal densities). Patients with abnormal OCTA had significantly higher mean age, higher DKA frequency, and lower height SDS (p=0.034, 0.011 and 0.001 respectively). Univariate and multivariate analysis revealed age and DKA at diabetes presentation are significant predictors for abnormal OCTA. Conclusion: OCTA can be used in early detection of diabetic retinopathy in T1D adolescents especially with risk factors (Elevated HbA1c, frequent DKA, decreased height SDS and limited joint mobility).
Effect ropivacaine infiltration in incisional wound on caspase-3 expression and apoptosis squamous cells wound healing
Authors: Abdurrahman Abdurrahman , Airlangga Prananda S. , Susilo Imam
Published: April 2022

Wound healing and tissue regeneration consist of molecular and cellular process that occur right after wound formation. The intrinsic pathway of apoptosis, apoptosome produced to initiate the formation of Caspase 3 important role in apoptosis. One of the methods that accelerates wound healing process by eliminating pain by infiltration of local anesthesia. This study aims to determine the effect of ropivacaine infiltration as local anaesthesia in the expression of Caspase 3 and apoptosis. This study is an experimental study with randomized post-test only control group design. The samples of this study were 24 wistar rats. The rats divided into four groups then incised, either followed by 1 ml ropivacaine 0.2% infiltration or left as is. Excisional biopsy procedures were done on third and seventh day. Then analyzed by SPSS. Expression of Caspase 3 on squamous cell epithel of control and intervention group was found statistically different on day 3 (p=0.024) and day 7 (p=0.041). Number of apoptosis on squamous cell epithel of control and intervention was found statistically different on day 7 (p=0.031) but not on day 7 (p=0.414). Ropivacaine infiltration on incision wound decreased the expression of Caspase 3 on day 3 and 7; and apoptosis on day 7.
Kendali Robot Beroda sebagai Self Driving Car Berbasis Image Processing dengan Metode Fuzzy Logic
Authors: Yoga Sang Made Sedana , Pangaribuan Porman , Fuadi Azam Zamhuri
Published: April 2022

Seiring dengan perkembangan zaman, teknologi robotika di bidang industri dituntut untuk semakin berkembang, termasuk sektor industri otomotif. Contohnya, sistem kendali pada mobil secara otonom saat ini banyak dikembangkan oleh perusahaan mobil. Pengembangan teknologi ini, diharapkan dapat meminimalisir kecelakaan yang disebabkan oleh kesalahan manusia dalam mengemudikan mobil. Pada penelitian ini, sistem yang dirancang adalah robot beroda empat yang dapat berjalan secara otomatis berdasarkan deteksi objek. Robot beroda ini memungkinkan untuk pengenalan objek berupa garis layaknya garis marka pada jalan beraspal serta mampu mengendalikan mobil untuk melaju secara otomatis dengan metode logika Fuzzy. Selain itu, penelitian ini juga mengembangkan robot beroda untuk mendeteksi rambu lalu lintas dan lampu lalu lintas. Bila terdapat benda halangan, maka robot akan berbelok ke kanan untuk mengambil jalur kanan lalu menyalip halangan tersebut lalu kembali lagi ke jalur kiri. Ketika mendeteksi rambu stop maka, robot akan berhenti selama 5 detik. Kemudian, ketika robot mendeteksi lampu berwarna merah maka robot akan berhenti hinggga lampu berubah menjadi warna hijau. Berdasarkan hasil pengujian yang dilakukan, kinerja pengolahan citra sebagai sistem “Self Driving Car” berjalan dengan baik dimana robot bisa mendeteksi jalan, rambu ‘STOP’, replika mobil dan lampu lalu lintas. Pengolahan citra berbasis Haar-Like Classifiers dapat mencapai rata-rata akurasi sebesar 92,7%. Pada sistem kendali berbasis Logika Fuzzy, robot dapat berjalan pada jalurnya dengan baik hingga mencapai rata-rata akurasi sebesar 91,94%.
ÉTABLISSEMENT DU MICROBIOTE INTESTINAL
Authors: Marie-José BUTEL  , Anne-Judith WALIGORA-DUPRIET
Published: April 2022

L’intestin constitue un écosystème extrêmement complexe etune communauté microbienne dynamique où coexistent bactéries,archées, virus et eucaryotes (Weinstock 2012). Ce microbiote esten contact permanent avec les nutriments et les cellules de l’hôte,responsable d’interactions fortes. Les relations micro-organismeshôte ont cependant longtemps été regardées essentiellement sousl’angle de la pathogénicité, mais aujourd’hui le microbiote commensal est reconnu pour ses interactions bénéfiques l’organismehumain en faisant un véritable partenaire de l’hôte. Ce partenariatdébute à la naissance, la colonisation bactérienne commençantdès la rupture des membranes fœtales. Les bactéries, dont lenombre tout d’abord considéré comme 10 fois supérieur auxcellules eucaryotes, ont été récemment réévaluées à 3,8 1013, soitdans un rapport similaire à celui des eucaryotes de l’organismehumain (Sender et al. 2016). La majorité du microbiote résidedans l’intestin, essentiellement le côlon, où il est caractérisé parson haut niveau et sa large diversité. Le nombre d’espèces bactériennes a été évalué par les techniques de culture classique à 400 à500 espèces par individu. Par des techniques indépendantes de laculture ce nombre est évalué à plus de 1000 espèces par individu(Tap et al. 2009), soit environ 25 fois le génome humain (Qinet al. 2010). Le microbiote intestinal peut ainsi être considérécomme un véritable organe, ouvert, métaboliquement adaptableet rapidement renouvelable.
PROTEEAE
Authors: Antoine GRILLON  , Thomas GUILLARD  , Jean FRENEY
Published: April 2022

Prôteus, Dieu grec et fils de Poséidon, gardait les troupeauxde monstres marins appartenant à son père. Il avait le don dedivination, mais se refusait à donner sa prédiction à moins qu’iln’y soit forcé : il suffisait de le surprendre pendant sa sieste etde l’enchaîner. Il rendit à la fin sa prophétie après avoir essayéde s’échapper, prenant des formes effrayantes ou insaisissablescomme celle de l’eau ou du feu. C’est par analogie au Dieu Prôteusque Hauser décida en 1885 de retenir ce nom pour dénommer unebactérie également insaisissable, capable de changer de formeet douée d’une très grande mobilité lui permettant d’envahir lagélose (phénomène dit de « swarming »). En 1919, deux espècesde Proteus, Proteus mirabilis et Proteus vulgaris, furent reconnues(Janda et Abbott, 2006).
FACTEURS DE VIRULENCE BACTÉRIENS ET MÉCANISMES DE PATHOGÉNICITÉ ASSOCIÉS
Authors: Dominique AUBEL  , Martin FUSSENEGGER
Published: April 2022

Au cours de son évolution, l’homme a acquis des mécanismestrès complexes et diversifiés pour se protéger contre l’agressionde parasites tels que les bactéries. La peau est le premier obstacleauquel la bactérie doit faire face. Cette structure de nature légèrement acide, sèche, colonisée par une microflore de bactériesnon pathogènes, et constituée dans sa partie la plus externe decellules mortes constamment éliminées, n’est pas favorable audéveloppement des bactéries pathogènes. Toutefois certainesbactéries peuvent franchir cette barrière en raison d’altérationsdiverses telles que des coupures et des brûlures. La bactérie doitalors faire face au tissu lymphoïde sous-cutané constitué d’unensemble de cellules spécialisées dont le rôle est d’éliminer lesbactéries e
ANTISEPTIQUE ET ANTISEPSIE
Authors: Anne DAVIN-RÉGLI
Published: April 2022

Utilisés depuis l’Antiquité en traitement local des plaies etblessures, les antiseptiques doivent leur réputation aux travauxde Semmelweis et de Lister, comme à ceux plus proches, deLabarraque. L’avènement des sulfamides, puis des antibiotiques,qui a temporairement éloigné le spectre de la mort due à l’infection,les a fait reléguer au rang de médicaments1mineurs. L’évolutionactuelle de la pathologie infectieuse, à laquelle prennent part desphénomènes aussi divers que la résistance des micro-organismesaux antibiotiques, les états d’immunodépression des patients,et les pratiques thérapeutiques de plus en plus risquées, devraitinciter à mieux utiliser les antiseptiques, c’est-à-dire à pratiquerune antisepsie rigoureuse, bien adaptée aux circonstances. Maisla complexité de l’enjeu apparaît dès que l’on analyse la situationactuelle où la multiplicité des indications revendiquées illustreclairement l’utopie des utilisateurs.
L’ANTIBIOGRAMME ET SON INTERPRÉTATION EN 2018. IMPORTANCE DES CMI
Authors: François JEHL
Published: April 2022

L’antibiogramme consiste à déterminer la sensibilité et larésistance aux antibiotiques d’une bactérie isolée dans un prélèvement, et supposée être à l’origine d’un processus infectieux. Ils’agit d’une aide au choix du traitement d’une infection. Il ne doitêtre réalisé qu’à bon escient, à savoir lorsqu’il existe une forteprobabilité d’implication de la bactérie isolée dans un processusinfectieux. La réalisation d’un antibiogramme pour une bactérienon pathogène engage la responsabilité du biologiste car ellepeut inciter le clinicien à un traitement inutile, voire dangereuxpour le patient. Alors qu’il est relativement aisé d’identifier lessituations ou l’antibiogramme est utile, voire obligatoire, il estparfois beaucoup plus délicat d’identifier celles où il est inutile.Enfin, le traitement d’une infection par un antibiotique décrétéactif par un antibiogramme ne garantit pas le succès thérapeutique,alors qu’utiliser un antibiotique auquel la bactérie est résistanteest synonyme d’échec.
SYSTÈMES AUTOMATIQUES D’IDENTIFICATION BACTÉRIENNE
Authors: Philippe RIEGEL  , Yann DUMONT  , Jacques CROIZÉ  , Olivier DAUWALDER
Published: April 2022

Située au cœur des processus analytiques de bactériologieconventionnelle, l’identification bactérienne peut être réalisée àl’aide de méthodes phénotypiques, protéiques, immunologiqueset/ou moléculaires. Cependant, c’est à la fin des années 2000 quel’identification bactérienne en microbiologie clinique a connu une« révolution » avec l’introduction de la spectrométrie de massede type « Matrix Assisted Laser Desorption Ionization /Time ofFlight » [SM MALDI TOF] (Seng et al. 2009). Cette dernièrepermet l’obtention d’un résultat en quelques minutes, avec uninoculum très faible et avec des performances élevées (van Veen etal. 2010, Dubois et al. 2012, Martiny et al. 2012, Fang et al. 2012,Marko et al. 2012, and Vila et al. 2012). Néanmoins, l’achat et lamaintenance du spectromètre de masse et de la base de donnéesrestent couteux (Neville et al. 2011) et nécessitent un volume annueld’identifications supérieur à 12000/15000 identifications, seuil àpartir duquel le cout de l’identification bactérienne et fongiquedevient inférieur à ceux des galeries d’identification automatiséepar technique biochimique. D’autre part, la SM MALDI TOF nepermet pas de séparer des espèces phylogénétiquement prochesdont l’identification repose sur quelques caractères phénotypiques.Parmi ces espèces peut différentiables par la SM MALDI TOF onpeut citer entre autres Escherichia coli et Shigella sp, Klebsiellaspp, Raoultella spp, et certains streptocoques (se reporter auchapitre dédié sur la SM MALDI TOF). En deçà, l’identificationbactérienne automatisée par galerie biochimique conserve l’intérêtde pouvoir être réalisée sur les mêmes instruments que l’antibiogramme automatisé avec un niveau acceptable de performanceset un résultat en quelques heures. Ainsi, ce chapitre portera surl’étude de ces systèmes automatisés d’identification et exclue defacto, les identifications par spectrométrie de masse, par techniquesimmunologiques et par biologie moléculaire
LE GENRE PSEUDOMONAS
Authors: Sara ROMANO-BERTRAND  , Hélène MARCHANDIN  , Estelle JUMAS-BILAK
Published: April 2022

Le genre Pseudomonas a été décrit en 1894 par Migula surdes bases morphologiques. Un siècle plus tard, le genre a été subdivisé en 5 groupes d’hybridation ADN-ADN (Palleroni 1984).Les bactéries des groupes II à V sont aujourd’hui reclassées dansles genres Burkholderia (groupe II), Brevundimonas (groupe IV),Stenotrophomonas (groupe V) et dans la famille Comamonadaceae(groupe III). Le groupe d’hybridation I correspond aujourd’hui augenre Pseudomonassensu stricto. La phylogénie basée sur l’ARNribosomique (ARNr) 16S a confirmé cette classification et place legenre Pseudomonas dans le sous-phylum Gammaproteobacteria
ENTEROBACTER
Authors: Anne DAVIN-RÉGLI
Published: April 2022

Le genre Enterobacter comprend 20 espèces (tableau I).Enterobacter cloacae (espèce type du genre Enterobacter) et E.aerogenes sont les espèces les plus fréquemment isolées en cliniqueen France. Les études phylogénétiques ont permis de déclassertrois espèces, Enterobacter intermedius reclassé dans le genreKluyvera, Enterobacter dissolvens reclassé en tant que sous-espèced’Enterobacter cloacae et E. sakazakii dans le genre Cronobacteren 2007 (Iversen et al., 2007). Huit nouvelles espèces ont étédécrites sur la base de l’analyse du 16SrRNA ou du gène rpoB etsont issues d’extraits végétaux, de la rhizosphère des plantes oudu sol : Enterobacter ludwigii, E. radicintans, E. arachnidis, E.helveticus, E. mori, E. pulveris, E. soli et E. turicensis. Six des20 espèces d’Enterobacter, font partie du complexe Enterobactercloacae du fait de leur proximité phénotypique et génotypique.Précédemment, l’étude du complexe « Erwinia herbicola –Enterobacter agglomerans » a montré que le groupe était constituéen fait de nombreuses espèces dont certaines innominées (Beji etal., 1998). Mais une partie des espèces appartenant auparavant àce groupe ont été reclassées dans le genre Pantoea (Gavini et al.,1989). On exclut aussi du genre Enterobacter les espèces « vraies »d’Erwinia qui sont incapables de se développer à 35-37°C
La Compression dans la Maladie Veineuse Chronique (C0s – C4)
Authors: Mieke FLOUR
Published: April 2022

Les bas et les bandes de compression médicale ont leurplace reconnue dans presque toutes les indications de lamaladie veineuse chronique.Une sélection de la littérature récente dans les indicationsCEAP C0s – C4 permet une mise à jour de quelques preuvesd’évidence en tenant compte du dosage et du profil de lacompression exercée.Les dispositifs de compression nouveaux et en voie dedéveloppement sont très prometteurs mais nécessitent desétudes cliniques randomisées et/ou comparatives afin defonder leur valeur
Les contextes à proscrire et ne pas prescrire les AOD
Authors: A. EKOU
Published: April 2022

Les indications des AOD sont majeures avec la fibrillation atriale, la maladie thromboembolique veineuse et lachirurgie orthopédique à haut risque. En fait, de nombreuses situations cliniques restent contre-indiquées àl’usage d’AOD. Au sein d’une population ayant l’indicationtype AMM, des profils de patients ne seront pas éligibles àla prise d’AOD. il est donc important de respecter ceslimites d’utilisation dans l’attente de résultats plusconvaincants et démontrant le bien fondé de ce choix thérapeutique. Aujourd’hui le mésusage des AOD est responsable d’échec avec des performances bien en deça decelles des essais cliniques validant leur indication. Ladouble peine est d’âtre aussi exposé à un sur-risquehémorragique. Il faut voir juste et prescrite juste sansextrapoler de manière simpliste à des domaines nonencore validés par ses essais cliniques ou des données deregistre.
CHARACTERIZATION OF NANOCURCUMINOID FROM ETHANOL EXTRACT OF Curcuma Xanthorrhiza RHIZOME LOADED BY CHITOSAN AND ALGINIC AND ITS ANTIOXIDANT ACTIVITY TEST
Authors: S. Atun  , Y. Dewi
Published: April 2022

Curcuminoid is the main compound found in the Curcuma xantorrhiza rhizome. C. xantorrhiza plant which inIndonesia is known as temulawak is an herbal plant that is traditionally used to cure hepatitis, increase stamina, andas an anti-cholesterol. To enhance the stability, solubility and activity of the curcuminoid, should be developed intoa product nanoparticle. The purpose of this study was to characterize nanocurcuminoids from ethanol extracts fromthe C. xantorrhiza rhizome loaded by chitosan and alginic acid, and its antioxidant activity test. Thenanocurcuminoid formulation method uses ionic gelation. Chitosan nanocurcuminoid is made by mixingcurcuminoid solution and chitosan solution, then adding sodium tripolyphosphate (Na-TPP). Meanwhile, alginicnanocurcuminoids are made by mixing a solution of curcuminoids and alginic acid solutions, which are then addedto calcium ions.
Fécondabilité et conditions d’une fertilité normale
Authors: Dr Djedi DIAKITE
Published: April 2022

Environ 15 à 20 % des couples en désir d’enfantssont confrontés à l’infertilité.L’âge est cité comme étant le premier facteur déterminant la fertilité de la femme.Le stress oxydatif a été impliqué dans l’étiologie del’infertilité masculine.Les toxiques (Alcool, tabac, cannabis, etc.) enmême temps que les perturbateurs endocriniensont un impact négatif sur la fertilité du couple.En plus de tous ces facteurs l’alimentation, la polygamie et la fréquence des rapports sexuels aurontune influence sur le délai de conception.
Perturbateurs Endocriniens Environnementaux et Cancer du sein : de nouveaux facteurs de risque ?
Authors: Patrick FÉNICHEL
Published: April 2022

Les données épidémiologiques du cancer du sein,en faveur d’une véritable pandémie et le caractèrebien établi de son estrogéno-dépendance, suggèrent de nouveaux facteurs de risque qui pourraientimpliquer les xénoestrogènes en particulier les pesticides organo-chlorés. Leur présence ubiquitairedans l’environnement, y compris dans le sang, lelait maternel et le tissu adipeux, les caractéristiquesde perturbateurs endocriniens de ces composés,leur aptitude à exercer in vitro et chez l’animal, uneffet carcinogène sur les cellules mammaires, invitent, au nom du principe de précaution, à analyserattentivement leur participation éventuelle aux facteurs étiologiques du cancer du sein. En effet uneexposition prolongée à faibles doses à un cocktailde produits organiques persistants, pourrait êtredélétère en particulier dans des périodes critiquesd’exposition comme la période fœtale, associée àune susceptibilité génétique individuelle. Lesétudes épidémiologiques prospectives quantifiant lerisque en fonction de l’exposition, l’évaluation del’exposition chronique à l’aide de bio-marqueurs etl’identification des gènes de susceptibilité et/ousoumis à empreinte épigénétique, devraient permettre de clarifier la responsabilité de ces nouveaux facteurs étiopathogéniques, conduire à undépistage précoce de sujets à haut risque et faciliterl’établissement de normes internationales plus draconiennes pour l’utilisation des produits chimiquesde synthèse industriels ou agricoles.