bluuebunny/crossref_metadata_2025 huggingface dataset:
VEGF-A165 is the predominant VEGF-A isoform in platelets, while VEGF-A121 is abundant in serum and plasma from healthy individuals
Authors: Yamakuchi Munekazu , Okawa Masashi , Takenouchi Kazunori , Bibek Aryal , Yamada Shingo , Inoue Keiichi , Higurashi Kazuhiko , Tabaru Akito , Tanoue Kiyonori , Oyama Yoko , Higashi Sadayuki , Fujisaki Chieko , Kanda Hideaki , Terasaki Hiroto , Sakamoto Taiji , Soga Yoshiharu , Hashiguchi Teruto
Published: April 2023

Vascular endothelial growth factor A (VEGF-A) plays pivotal roles in regulating tumor angiogenesis as well as physiological vascular function. The major VEGF-A isoforms, VEGF-A121 and VEGF-A165, in serum, plasma, and platelets have not been exactly evaluated due to the lack of the appropriate assay system. Antibodies against human VEGF-A121 and VEGF-A165 (hVEGF-A121 and hVEGF-A165) were successfully produced and Enzyme-Linked ImmunoSorbent Assay (ELISA) for hVEGF-A121 and hVEGF-A165 were separately created by these monoclonal antibodies. The measurement of recombinant hVEGF-A121 and hVEGF-A165 by the created ELISA showed no cross-reaction between hVEGF-A121 and hVEGF-A165 in conditioned media from HEK293 cells transfected with either hVEGF-A121 or hVEGF-A165 expression vector. The levels of VEGF-A121 and VEGF-A165 in serum, plasma, and platelets from 59 healthy volunteers proved that VEGF-A121 level was higher than VEGF-A165 in both plasma and serum in all the cases. VEGF-A121 or VEGF-A165 in serum represented higher level than that in plasma. In contrast, the level of VEGF-A165 was higher than VEGF-A121 in platelets. The newly developed ELISAs for hVEGF-A121 and hVEGF-A165 revealed different ratios of VEGF isoforms in serum, plasma, and platelets. Measuring these isoforms in combination provides useful information as biomarkers for diseases involving VEGF-A121 and VEGF-A165.
Factors associated with research participation in a large primary care practice-based pediatric cohort: Results from the TARGet Kids! longitudinal cohort study
Authors: Li Xuedi , Keown-Stoneman Charles D. G. , Borkhoff Cornelia M. , Wong Peter D. , Arafeh Dana , Tavares Erika , Thadani Sharon , Maguire Jonathon L. , Birken Catherine S. ,   on behalf of the TARGet Kids! Collaboration
Published: April 2023

Background

All longitudinal cohort studies strive for high participant retention, although attrition is common. Understanding determinants of attrition is important to inform and develop targeted strategies to improve study participation. We aimed to identify factors associated with research participation in a large children’s primary care cohort study.

Methods

In this longitudinal cohort study between 2008 and 2020, all children who participated in the Applied Research Group for Kids (TARGet Kids!) were included. TARGet Kids! is a large primary care practice-based pediatric research network in Canada with ongoing data collection at well-child visits. Several sociodemographic, health, and study design factors were examined for their associations with research participation. The primary outcome was attendance of eligible research follow-up visits. The secondary outcome was time to withdrawal from the TARGet Kids! study. Generalized linear mixed effects models and Cox proportional hazard models were fitted. We have engaged parent partners in all stages of this study.

Results

A total 10,412 children with 62,655 total eligible research follow-up visits were included. Mean age at enrolment was 22 months, 52% were male, and 52% had mothers of European ethnicity. 68.4% of the participants attended at least 1 research follow-up visit. Since 2008, 6.4% of the participants have submitted a withdrawal request. Key factors associated with research participation included child age, ethnicity, maternal age, maternal education level, family income, parental employment, child diagnosis of chronic health conditions, certain study sites, and missingness in questionnaire data.

Conclusions

Socioeconomic status, demographic factors, chronic conditions, and missingness in questionnaire data were associated with research participation in this large primary care practice-based cohort study of children. Results from this analysis and input from our parent partners suggested that retention strategies could include continued parent engagement, creating brand identity and communication tools, using multiple languages and avoiding redundancy in the questionnaires.
The sum of all parts: A multi-level exploration of racial and ethnic identity formation during emerging adulthood
Authors: Grilo Stephanie A. , Semler Mollie R. , Rameau Stephanie
Published: April 2023

According to the 2020 U.S. Census, the multiracial population measured at 33.8 million, nearly a 300% increase from the 2010 U.S. Census. The significant increase is due in part to improvements in measures to categorize this population. However, there is a dearth of research on the factors and processes that affect multiracial identity formation. The researchers investigated the precipitating factors to the formation of multiracial identification. Participants were recruited through social media campaigns. Hour-long in-depth interviews were conducted with 21 participants via Zoom, following an interview guide consisting of 9 categories: racial and ethnic identification, childhood and upbringing, family influence, peer engagement, health and wellbeing, experiences of discrimination, forming resilience, language, and demographics. Coding of transcripts and thematic analyses revealed that individual, interpersonal and community level influences influenced identity development differently depending on the individual’s positionality within the life course. This supported the use of both the life course framework as well as the social ecological framework when examining multiracial identity development.
Minor painting: Outsiders and outliers
Authors: Hunt Andrew
Published: April 2023

The editorial surveys the current terrain of contemporary self-taught and outsider art. Using Deleuze and Guattari’s Towards a Minor Literature to suggest a specific category of minor painting, the text discusses how museological discourse on outsider art that developed over the twentieth century has been transformed over the past decade by large museum exhibitions and smaller community organizations’ activities. These include key examples such as the National Gallery of Art, Washington’s exhibition Outliers and American Vanguard Art curated by Lynne Cooke, and White Columns’s exemplary programme that supports visionary and self-taught artists in New York City. The text outlines how these examples alongside curatorial activism and reappraisal have attempted to recalibrate art history and provides an analysis of the inclusion of outsider and self-taught art in biennales such as Venice, quinquennials such as Documenta and small publicly funded spaces with a desire for equality and inclusion.
Matthew Higgs interviewed by Andrew Hunt
Authors: Hunt Andrew
Published: April 2023

This interview considers Matthew Higgs’s role in programming work by self-taught artists and those with developmental disabilities within the context of White Columns, a non-profit artist-run space located in Chelsea, New York City. The conversation describes the active support of work before any critical or institutional consensus emerges around it and explores how painting by self-taught artists and those with developmental disabilities can provide a productive counterpoint to self-reflexive work or art more critical of the narrative of painting as a medium. The term ‘outsider’ is also scrutinized as a useful generalization for painting that operates outside of conventional forms of education and existing foundational narratives in culture. Also discussed is the impact of exemplary historical curators and dealers in the United States and Germany who serve to act as model ‘maverick iconoclasts’.
Apart from judgement
Authors: Johnson Helen
Published: April 2023

In this text the relation between art therapy and art as such is explored, drawing on moments in the emergence of art therapy practice in a western context. The text examines differences in the role of imagination for art and art therapy, and identifies the roles of audience and conceptual rationale as points of difference between the two.
Marking Time: Art in the Age of Mass Incarceration, Curated by Nicole R. Fleetwood
Authors: Simon Adam
Published: April 2023

Review of: Marking Time: Art in the Age of Mass Incarceration, Curated by Nicole R. Fleetwood

MoMA/PS1, New York, 17 September 2020–5 April 2021
The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis
Authors: Vatsalya Vatsalya , Feng Wenke , Kong Maiying , Hu Huirong , Szabo Gyongyi , McCullough Arthur , Dasarathy Srinivasan , Nagy Laura E. , Radaeva Svetlana , Barton Bruce , Mitchell Mack , McClain Craig J.
Published: April 2023

INTRODUCTION:

We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking in patients with alcohol use disorder and moderately severe alcohol-associated hepatitis.

METHODS:

Forty-six male and female individuals with alcohol use disorder and moderate alcohol-associated hepatitis (12 ≤ model for end-stage liver disease score < 20, aged 21–67 years) received either LGG (n = 24) or placebo (n = 22). Data were collected/assessed at baseline and at 1, 3, and 6 months.

RESULTS:

LGG treatment was associated with a significant reduction in liver injury after 1 month. Six months of LGG treatment reduced heavy drinking levels to social or abstinence levels.

DISCUSSION:

LGG treatment was associated with an improvement in both liver injury and drinking.
The Contemporary Probability of Occult Colorectal Cancer in Patients With Colitis-Related Dysplasia Undergoing Colectomy
Authors: Boparai Eshandeep S. , Lee Jeffrey K. , Zhu Shiyun , Shirazi Aida , Velayos Fernando S.
Published: April 2023

Occult colorectal cancer (CRC) has historically driven recommendations for colectomy in patients with inflammatory bowel disease with dysplasia. We defined the contemporary risk of occult CRC at colectomy among 93 patients with inflammatory bowel disease with dysplasia based on endoscopic appearance, resection, and concordance between site of cancer at colectomy and dysplasia at colonoscopy. Contrary to our hypothesis, we found that occult CRC at colectomy remains elevated in high-grade polypoid and invisible dysplasia. It was infrequent in other visible lesions. When present, occult cancer occurred in the same segment as dysplasia, suggesting the historic concern of missing a remote cancer is low.
Exploring the Educational Potential of ‘Discomfort’ in Teaching for Social Justice: Based on Affect Theory
Authors: Choi Yuri , Park Jiae
Published: April 2023

Discomfort has been regarded as a de-politicized and psychologized matter such as personal preference or an inappropriate object to be corrected, with its pedagogical possibilities not being fully explored in the context of teaching for social justice. This study aims to explore the educational potential of discomfort as a drive for ethical and political self-transformation and solidarity for social change. For this purpose, this study explores the dynamics of emotion in the context of teaching for social justice and interrogates how discomfort has been located within it. Affect theory is utilized to expand the existing understandings of emotions, and from here, the educational potential of discomfort is emerged. Through the lens of affect, discomfort can be seen as a force that fetishizes ‘Other’ and reproduces social injustice and inequity, at the same time, it can be seen as a force to make it possible for us to question the existing bodily boundaries between ‘Us’ and ‘Other,’ thus fostering new ethical and political ‘becoming’ and affective self-transformation. To utilize discomfort as a pedagogical resource in teaching for social justice, some relevant issues are discussed such as ‘critical affective literacy,’ ‘classroom as a safe space,’ and ‘the relationships between pedagogy of discomfort and pedagogy of empathy.’ The need to conduct more theoretical and empirical research on affective dimensions of teaching for social justice in South Korean context is suggested.
자주적 어휘선택 전략에 의한 L2 어휘학습 및 학습자 견해
Authors:   Center For Educational Research, Park Eun
Published: April 2023

Purpose: This study aimed to examine the effects of Vocabulary Self-collection Strategy (VSS) withglossing on L2 word recall and retention as well as learner perspectives on vocabulary knowledgeand word consciousness by the strategy in EFL classroom contexts. Methods: For the study, sixty-four learners were randomly allocated for both VSS accompanied withL1 glossing (VSSL1) and VSS accompanied with L2 glossing (VSSL2) groups. Data were collectedthrough a pre-test for collecting target words, two immediate and two delayed post vocabulary tests,and a retrospective questionnaire. Results: The results revealed that VSSL2 group significantly outperformed in immediate word recalland delayed retention in receptive and productive knowledge than VSSL1 group. In addition, overall,positive perceptions on the strategy were found in vocabulary knowledge and word consciousnessfrom the two groups. It is noteworthy that the VSSL2 group showed significantly higher mean scoreof the statement regarding long-term memory effect by the strategy. Conclusion: The results from VSS L2 group appeared to be attributed to deeper processing for form-meaningconnections of target words with higher involvement load in need to understand, search for themusing L2-L2 dictionary, and evaluation to check proper meanings in the context on their own. Thiscould be strengthened by the cooperative classroom discussions with peers and teacher guidance forfull comprehension of target language input. (Dankook University)
Experiences and Needs of Caregivers of People with Disabilities on S upports for the Caregivers
Authors:   Center For Educational Research, Lee Misuk , Ra In-Jong , Han Min-Kyun , Joe Yun-gil
Published: April 2023

Purpose: This study examined the experiences of benefiting from the support provided to the caregiversof people with disabilities, and examined the caregivers' perception of what support is necessary for them. Methods: For this study, a focus group interview was conducted with 17 caregivers of people withdisabilities, including parents and siblings of the people with disabilities. Results: The results of the study were as follows. First, the caregivers with people with disabilitieswere suffering from caregiving due to a lack of various programs and institutions for the people withdisabilities. Second, the caregivers did not know that the support was focused on the caregivers, eventhough they were receiving supports for themselves. Third, the caregivers felt sorry that they couldonly receive supports by finding supports for the people with disabilities or the caregivers on theirown. Finally, the caregivers had requests for supports in various areas such as educational, psychological,emotional, legal, and medical assistance. Conclusion: The support programs for the people with disabilities and their families should be expandedcomprehensively regardless of age or the income level of the family. As well, the entire process ofthe support for the caregivers of people with disabilities should be implemented more systematically.
Principles and Directions of Korean Language Classrooms for Digital Literacy Education
Authors:   Center For Educational Research, Shin Yun-Kyung
Published: April 2023

Purpose: This study was conducted to suggest the principles and directions of Korean language classdesign for digital literacy education in order to develop core competencies of the Korean languagedepartment following the release the 2022 revision of the elementary Korean language curriculum. Methods: For this research, the contents system was analyzed, focusing on the 'media' area in the2022 revised elementary Korean language curriculum, and the 'Digital Literacy' of CCSS (CommonCore State Standards) according to the US grade level presented by Hutchison & Colwell (2015)‘Functional teaching and learning cases’, Australia's language curriculum digital literacy educationcontent element analysis, core values of Korean language classes and research on the Korean languageclass process review, and implications related to the 'class design' from previous domestic and foreignstudies related to digital literacy education field. Results: As a result, it was possible to present the basic direction for designing Korean languageclasses that digital literacy education should pursue under the principles of class design from amacroscopic and microscopic perspective for digital literacy education in elementary Korean classesand the core values of Korean classes. Conclusion: The main principles to be considered when designing and operating classes in whichlearners can actively respond to the new establishment of the ‘media’ area and the changes in themedia environment of digital transformation are discussed.
SENSORIAMENTO REMOTO E MÉTRICAS DA PAISAGEM COMO FERRAMENTAS DE ANÁLISE DO POTENCIAL DE ECOTURISMO EM UNIDADES DE CONSERVAÇÃO: ESTUDO DE CASO NO PARQUE ESTADUAL SERRA DO INTENDENTE – MG - BRASIL
Authors: Fonseca Charles de Oliveira , Gonçalves Deleon , Lage Nayara , Elmiro Marcos Antônio Timbó
Published: April 2023

O ecoturismo é um segmento que auxilia na conservação dos espaços naturais e sua biodiversidade. Entendendo-se a complexidade das paisagens naturais, buscou-se uma análise transversal que cotejasse respostas por meio de métodos de sensoriamento remoto e métricas da paisagem.  A área de estudo foi o Parque Estadual Serra do Intendente (PESI), localizado na Serra do Espinhaço. Foram utilizadas imagens dos satélites Landsat 5 e 8, dos anos de 1990 e 2020, que possibilitaram a elaboração dos mapas de uso e cobertura da terra, com qualidade temática em acurácia global de 99,7% e 86,5% e índice Kappa de 99,6% e 80,0%. As métricas da paisagem indicaram um aumento de 53,3% para 57,7% na ocorrência dos campos rupestres, uma redução dos campos graminosos (23,7% para 14,5%) e de solo exposto (0,6% para 0,1%) que, possivelmente, estão associados às áreas anteriormente ocupadas pelo gado, e um aumento da área de floresta estacional semidecidual (21,8% para 27,6%). Ao cruzar os mapeamentos e os resultados quantitativos, foram obtidos subsídios para melhor entendimento da organização espacial. Diante das análises, conclui-se que houve um aumento das formações naturais, consoante com as funções de conservação do PESI, resultando no aumento da potencialidade do ecoturismo.
Development of Ergonomics Checklist on Stroke Therapy Aids (Wearable Elbow Exoskeleton)
Authors: Susanto Novie , Saraswati Christ Novia , Budiawan Wiwik , Ismail Rifky
Published: April 2023

This study aims at building a checklist used for each stage of wearable Elbow Exoskeletons development. The Wearable Elbow Exoskeleton is one of the handstroke therapy aids which was developed by Diponegoro University. The product is still in the form of a prototype so some tests must be carried out before the product is tested on respondents. The test so far is still focused on functionality tests. This study provides a general checklist for ergonomics testing of stroke therapy aid products. The method of the checklist is developed based on an exploratory study and literature review for producing appropriate tests related to product characteristics. There are three iterations of product development and each version repairs the previous version. The implementation of the checklist shows that on the third iteration, the product is aligned with the objective of development and reaches the targeted level of respondents’ satisfaction.
Kůň v pedagogické praxi. Aktivity s koněm (nejen) v rámci EVVO pro MŠ a ZŠ.
Authors: Janáková Monika
Published: April 2023

Téma článku volně navazuje na autorčin text Horse Assisted education (,, Učení s asistencí koní) a jeho potenciál v oblasti pedagogiky a environmentální výchovy. Má za cíl čtenáře inspirovat jak daný směr realizovat v praxi v rámci program EVVO pro MŠ  a ZŠ nebo v rámci táborů či jiných volnočasových aktivit dětí. Článek není přímo metodikou, ale je snahou o koncepční uchopení a metodickou inspiraci pro praxi učitelů EVVO, lektorů, jezdeckých instruktorů atd. Cílem je ukázat, že kůň a aktivity s ním, může být nejen prostředkem pro výuku jezdectví, ale že poskytuje i další zajímavé možnosti pro práci s dětmi v rámci výchovy a vzdělávání.
Study on CO2 absorption performance of ternary DES formed based on DEA as promoting factor
Authors: Shi Shengyou , Li Shuie , Liu Xiangwei , Liu Chengfang
Published: April 2023

In this study, we used tetraethylammonium chloride (TEAC), diethanolamine (DEA), and N-methyldiethanolamine (MDEA) to prepare ternary DES and binary DES to absorb CO2. We found that their formation was due to the hydrogen bond interaction between hydrogen bond acceptor and hydrogen bond donor (HBD). Surprisingly, TEAC/MDEA/DEA can react with CO2, but TEAC/MDEA cannot react with CO2. Unexpectedly, after adding DEA to TEAC/MDEA, the ternary TEAC/MDEA/DEA DES can react with CO2. Nuclear magnetic resonance spectroscopy and Fourier infrared spectroscopy results showed that the accidental CO2 absorption behavior mainly depended on the HBD DEA, because the imine group in DEA reacted with CO2 to form carbamate, thereby absorbing CO2, while the hydroxyl group on MDEA and the hydroxyl group of DEA did not interact with CO2. Through thermal stability analysis, TEAC/MDEA/DEA system with the molar ratio of 1:3:4 is more stable. We further studied the influence of molar ratio, temperature, water content, and other factors on the absorption of CO2 by ternary DES. In addition, TEAC/MDEA/DEA (1:3:4) was regenerated at 80°C, and the absorption capacity of DES was almost unchanged after five absorption–desorption cycles.
Philosophical Objections to Media Contexts of Terraforming
Authors: Sámelová Anna
Published: April 2023

This theoretical study focuses on terraforming in the context of the industrially created image of the world by the mainstream media and on philosophical objections to the terraforming activities of humanity. The first part discusses the specific nature of the spectacularism of media images, while the second part explains the paradigmatic change in media images. The third part then turns to the ethically grounded binarism of current philosophical reflections on human expansion into space. The purpose of this study is to consider objections to the mainstream media focus from the viewpoint of contemporary philosophy. The theoretical reflection is based on induction and deduction in order to point out the ambivalence of what humanity can do in the framework of progress in the sense of what it is capable of and in the sense of what is right.
Physicochemical properties and structure of buckwheat flour modified by steam-treatment
Authors: Yang Bowen , Wang Jiake , Yang Tongliang , Zhang Yifu , Wang Yuhe , Qiang Siqi , Zhou Junjun , Li Shuhong , Chen Ye
Published: April 2023

The natural buckwheat flour exhibits poor processing behaviour due to its conservative structure and the lack of gluten protein, thereby limiting its use in the food industry. The replacement of chemical modification with sustainable, environmentally friendly steam treatment is, currently, technically feasible and promising for most chemical modification methods. The data showed that the steam-treated buckwheat flour degree of gelatinization increased to 99.3 g/100 g, and water absorption increased to 3.93 g/100 g. Also, particle size of the samples in the trial group was significantly larger compared to the control group. Scanning electron microscopy and infrared tests showed that not only did the steam treatment disrupt the granular structure of the buckwheat flour, but its proximity crystalline ordering structure Importantly, rheological behaviour tests showed that the steam-treated buckwheat gel exhibited a better viscoelasticity. Consequently, steam-treated pre-gelatinized buckwheat flour readily forms a tight network structure and provided important information for potential processing applications.
Phase formation and electrical properties study of PVDF thick films synthesized by solution casting method
Authors: Parida A P Kajal , Swain Sujata , Sahu Rashmirekha , Negi Rashmi Rekha , Samanta Buddhadev , Kumar Pawan
Published: April 2023

In this study, polyvinylidene fluoride (PVDF) thick films with thickness ∼180 µm were synthesized by solution casting. X-ray diffraction study established the co-existence of both α and β-phases. Raman spectroscopy of the synthesized PVDF thick films corroborated the existence of α and β-phases in 0.71:1 ratio. Surface micrographs of PVDF thick films showed dense microstructure with grain size ∼10 µm. Additionally, the room temperature values of dielectric constant and dielectric loss at 100 kHz were measured to be ∼20 and 0.33, respectively. Furthermore, ferroelectric behavior of PVDF thick films was confirmed by the polarization versus electric field (P–E) hysteresis loop study. A leakage current density of 1.55 × 10−5 A cm−2 at an applied electric field of 500 kV cm−1 was obtained in PVDF thick films.
Thermodynamic analysis of the effect of rotation on gas adsorption
Authors: Kosheleva Ramonna I. , Karapantsios Thodoris D. , Kostoglou Margaritis , Mitropoulos Athanasios Ch.
Published: April 2023

This study examines the effect of a short term rotation on a system of constant volume. Adsorption of CO2 is performed on Activated Carbon (AC) at 281, 293 and 298 K with a special designed device that allows rotation. The adsorption isotherms were conducted up to 10 bar for both No Rotational (NoROT) and Rotational (ROT) cases. The ROT case refers to 60 s of rotation at 5000 rpm. The experimental results were fitted to Langmuir as well as to Dubinin–Astakhov (D–A) models with the latter presenting the best fit. A detailed thermodynamic analysis is performed in order to quantify the overall contribution of the rotation on gas adsorption compared to static case. For the ROT case, the maximum amount adsorbed (q
max) is by 12 % higher than the NoROT counterpart, while a decrease in chemical potential as surface loading is increased, indicates that the process after rotation is entropy driven. The outcome of this work suggests that rotation enables gas molecules to access previously inaccessible sites, thus gaining more vacancies due to better rearrangement of the adsorbed CO2 molecules.
Experimental observations of communication in blackout, topological waveguiding and Dirac zero-index property in plasma sheath
Authors: Li Jianfei , Wang Ying , Zhou Zhongxiang , Yao Jingfeng , Liu Jianlong , Lan Zhihao , Yuan Chengxun
Published: April 2023

The plasma sheath causes the spacecraft’s communication signal to attenuate dramatically during the re-entry period, which seriously threatens the astronauts. However, valid experimental protocols have not been obtained hitherto. To realize the propagation of electromagnetic waves in negative permittivity background of the plasma sheath, alumina columns are embedded in the plasma background to form plasma photonic crystals, which can support the coupling of evanescent waves between the alumina columns. We experimentally demonstrate the realization of communication in blackout scenario by achieving a complete passing band in the plasma cutoff region. For high frequency communications in the plasma sheath, electromagnetic wave propagation based on topological edge states is also experimentally demonstrated. Furthermore, we realize a triply-degenerate Dirac cone formed dynamically at the center of the Brillouin zone by modulating the electron density, where electromagnetic wave exhibits high transmittance and does not experience phase accumulation at the Dirac point. Our work thus not only provides an effective approach to overcome the communication blackout problem, but the design can also be served as a promising experimental platform to explore topological electromagnetic phenomena.
Tilting light’s polarization plane to spatially separate the ultrafast nonlinear response of chiral molecules
Authors: Rego Laura , Smirnova Olga , Ayuso David
Published: April 2023

Distinguishing between the left- and right-handed versions of a chiral molecule (enantiomers) is vital, but also inherently difficult. Traditional optical methods using elliptically/circularly polarized light rely on linear effects which arise beyond the electric-dipole approximation, posing major limitations for ultrafast spectroscopy. Here we show how to turn an ultrashort elliptical pulse into an efficient chiro-optical tool: by tilting its polarization plane towards its propagation direction. This forward tilt can be achieved by focusing the beam tightly, creating structured light which exhibits a nontrivial polarization pattern in space. Using state-of-the-art computational modelling, we show that our structured field realizes a near-field interferometer for efficient chiral recognition that separates the nonlinear optical response of left- and right-handed molecules in space. Our work provides a simple, yet highly efficient, way of spatially structuring the polarization of light to image molecular chirality, with extreme enantio-efficiency and on ultrafast time scales.
Tungsten trioxide nanocomposite for conventional soliton and noise-like pulse generation in anomalous dispersion laser cavity
Authors: Mansor Maisarah , Zainol Abidin Nadiah Husseini , Mohd Yusoff Norita , Lau Kuen Yao , Chyi Josephine Liew Ying , Janyani Vijay , Garg Amit Kumar , Alresheedi Mohammed Thamer , Mahdi Mohd Adzir
Published: April 2023

This work demonstrates the employment of tungsten trioxide/polydimethylsiloxane nanocomposite saturable absorber (WO3/PDMS-SA) in realizing mode-locked conventional soliton (CS) and noise-like pulse (NLP) laser generation in net anomalous dispersion. The switching formation from CS regime of 970.0 fs pulse duration to NLP regime of 182.0 fs coherent spike with 65.3 ps pedestal was achieved by varying its pump power. The pulse laser exhibited good stability of 50.76 and 49.82 dB signal-to-noise ratio at 9.09 MHz fundamental repetition rate and trivial variation during stability test for CS and NLP regime, respectively. This work expresses the feasibility of WO3/PDMS-SA in attaining various types of mode-locked pulse phenomena using a fixed cavity configuration conceivably beneficial for compact dual-purpose laser systems.
Synthesis and characterization of new polycarbonates free of bisphenol A components (BPA-free) based on dimethyl/diphenyl carbonate and diphenylmethane derivative
Authors: Wnuczek Krystyna , Puszka Andrzej , Podkościelna Beata
Published: April 2023

The paper studies thermal characteristics of new polycarbonates obtained using the bisphenol A-free technology. Thermal tests of polycarbonates were carried out in a wide temperature range using the DSC (diffrential scanning calorimetry) and TG (thermogravimetry) analyses. The DSC data confirmed that all materials are homogeneous whereas the endothermic peaks are responsible for melting. Additionally, the analysis of the released gases was made by means of the infrared spectroscopic analysis. Our research proved that the new polycarbonates are relatively heat resistant. In the range of the thermal destruction of the studied materials there can be considered, two types of degradation reactions. The first step around 200 °C and the second one around 300 °C. Gel permeation chromatography were performed to determined molar masses of polymers. XRD analysis showed that the obtained polycarbonates showed a partially crystalline structure.
A pre-Hispanic religious landscape on the arid Andean altiplano of Bolivia
Authors: Cruz Pablo , Joffre Richard , Vacher Jean J.
Published: April 2023

Research carried out in the Carangas region of highland Bolivia has identified a surprising concentration of pre-Hispanic religious sites, which are linked both to ancient Andean cults of wak'a (sacred mountains, tutelary hills and mummified ancestors) and to the Incan settlement of the region. Of these sites, one ceremonial centre stands out for its unprecedented characteristics for the Andes.
The Epidemiology of Circulating Rotavirus Associated with Diarrhea in Egyptian Kids and Calves: A Review
Authors: Ghonaim Ahmed H. , Hopo Mai G. , Ghonaim Noha H. , Jiang Yunbo , He Qigai , Li Wentao
Published: April 2023

Acute gastroenteritis (AGE) induced by rotavirus has been a major disease burden in Egypt since 1981 when rotavirus was first reported in humans and calves. Genome segmentation facilitates the emergence of new virus serotypes, which allows reassortment during mixed infections, and is a characteristic feature of the family Reoviridae to which rotavirus belongs. The rotavirus genome involves 11 double-stranded RNA gene segments encoding 6 non-structural (NSP1–6) and 6 structural (VP1–4, VP6, VP7) proteins. Rotavirus A has a zoonotic potential associated with diarrhea. The primary strategy for prevention and control of bovine and human rotavirus infections is vaccination; however, routine rotavirus vaccination has not been implemented in the National Immunization Program. We evaluated studies published over the last 30 years that pertained to the epidemiology of circulating rotavirus genotypes among children, calves, and environmental samples in Egypt. The analysis revealed a rotavirus prevalence of 15%–100%, with diarrhea occurring throughout the year, but generally peaking during the cold months. G1 was the predominant genotype in children, followed by G2, G3, G4, G8, G9, and G12 throughout the study duration. Mixed infections were also detected. G6 was the predominant genotype in calves, followed by G10. There are still gaps in knowledge regarding molecular data of rotavirus infections in humans, animals, and environmental samples in Egypt, as well as the zoonotic potential of rotavirus disease. Therefore, it is critical to continue rotavirus surveillance in Egypt to further understand the epidemiology of rotavirus infections and the emerging new genotypes.
Beyond the Movie Theater
Authors: Waller Gregory A.
Published: April 2023

Beyond the Movie Theater excavates the history of non-theatrical cinema before 1920, exploring how moving pictures were used in ways distinct from theatrical cinema. Looking away from the glimmer of the theater screen and stepping outside the light of the marquee, Beyond the Movie Theater reveals that sponsored moving pictures were put to a variety of uses and screened at a host of sites, targeting a surprisingly wide range of audiences. Relying on contemporary print sources and ephemera, Gregory A. Waller charts a heterogeneous, fragmentary, and rich field that cannot be explained in terms of a master narrative concerning origin or institutionalization, progress or decline. Uncovering how and where films were put to use beyond the movie theater, this book complicates and expands our understanding of the history of American cinema, underscoring the myriad roles and everyday presence of moving pictures during the early twentieth century.
Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists
Authors: Zhang Dongqi , Liu Yongfeng , Zaidi Saheem A , Xu Lingyi , Zhan Yuting , Chen Anqi , Guo Jiangtao , Huang Xi‐Ping , Roth Bryan L , Katritch Vsevolod , Cherezov Vadim , Zhang Haitao
Published: April 2023

The peptide hormone angiotensin II regulates blood pressure mainly through the type 1 angiotensin II receptor AT1R and its downstream signaling proteins Gq and β‐arrestin. AT1R blockers, clinically used as antihypertensive drugs, inhibit both signaling pathways, whereas AT1R β‐arrestin‐biased agonists have shown great potential for the treatment of acute heart failure. Here, we present a cryo‐electron microscopy (cryo‐EM) structure of the human AT1R in complex with a balanced agonist, Sar1‐AngII, and Gq protein at 2.9 Å resolution. This structure, together with extensive functional assays and computational modeling, reveals the molecular mechanisms for AT1R signaling modulation and suggests that a major hydrogen bond network (MHN) inside the receptor serves as a key regulator of AT1R signal transduction from the ligand‐binding pocket to both Gq and β‐arrestin pathways. Specifically, we found that the MHN mutations N1113.35A and N2947.45A induce biased signaling to Gq and β‐arrestin, respectively. These insights should facilitate AT1R structure‐based drug discovery for the treatment of cardiovascular diseases.
Ecobox : Inovasi Penyimpan Makanan Non CFC Berbasis Peltier Thermoelektrik Yang Murah, Hemat Energi dan Ramah Lingkungan
Authors: Faisal Reza , Nurulloh Mohamad Ikhsan , Harmiansyah Junaedi
Published: April 2023

Penggunaan kulkas sebagai pendingin semakin meningkat diiringi dengan penggunaan bahan kimia berbahaya. Hal ini disebabkan karena di dalam kulkas terdapat komponen  yang tidak ramah lingkungan yaitu Freon. Selain itu desainnya kurang praktis karena terlalu besar sehingga mobilitasnya rendah, karena itu diperlukan penyimpan makanan yang portable, memiliki estetika, bobot ringan, namun tetap hemat energi dan memiliki kemampuan pendinginan yang sama dengan pendingin konvensional. Tujuan karsa cipta ini yaitu: (1) Mancang dan mendesain ECOBOX sebagai inovasi kulkas ramah lingkungan (2) Mengetahui efisiensi ECOBOX dibandingkan kulkas dipasaran. Metode pendekatan yang digunakan adalah metode eksperimental di Laboratorium Fisika Universitas Negeri Semarang. Perancangan dengan menentukan spesifikasi rancangan yang memenuhi spesifikasi yang ditentuan, menentukan alternatif terbaik dan membuktikan bahwa rancangan yang dipilih memenuhi spesifikasi efektif dan efisien dengan biaya yang murah. Sistem pendingin ECOBOX tidak menggunakan CFC tetapi menggunakan peltier thermoelektrik. Pasir besi digunakan sebagai transfer kalor untuk menjaga suhu dingin yang telah dicapai. ECOBOX memiliki Kapasitas 40 L. Temperatur dingin mencapai 20OC. Efisiensi ECOBOX sebesar 85% dibandingkan dengan keawetan buah pada kulkas konvensional.
The Role of Citizens in Preventing Radicalism and Terrorism in Indonesia
Authors: Hamidah Linda Tri
Published: April 2023

Pancasila was established as the ideology of the Indonesian nation to become a guideline for the life of its citizens. Pancasila teaches to live full of tolerance, but not all citizens carry out the Pancasila values. There is an anti-Pancasila movement that can lead to the formation of a radicalism and terrorism in this country. The doctrine intends to turn this country into an Islamic State which has resulted in this nation becoming an intolerant, fanatical, and exclusive. Radicalism does not stand by itself, but behind that there is an element of profit or political and ideological binding which is like fundalism or challenges the basic structure that makes religion the principle of life. In various sources of radicalism is not caused by one factor, but can be caused by many factors such as the number of poverty rates, the rapidly developing global level, and the spread of an understanding of wahhabism originating from Saudi Arabia. Conservative wahhabism into this nation has given rise to an exclusive group that likes to slander other people who are not in their group who consider it an infidel, an enemy and may be fought. Radicalism itself is the starting point for the creation of terrorism. Terrorism is the use of cruelty which is targeted at civilians to cause fear which is usually an attempt to achieve a political goal. Terrorism is misleading, although it has a different basis for political goals but they have a common goal of being willing to harm or even kill civilians.
Legal Protection Regarding Names and Visual Artists in the World of Writing from a Copyright Perspective
Authors: Zarnuji Zhafiratuz Zuhriyyah
Published: April 2023

In this scientific article, the author will discuss the latest problems related to the world of fanfic genre authorship which is currently on the rise because of the rising prestige of world artists and more specifically related to the rise of the Korean entertainment industry as trendsetters in various sectors, especially for book lovers or who like to read books, Fanfiction works are now starting to run rampant on various social media platforms, namely the most talked about and the most impactful is blue bird social media or twitter, many new writers who produce fanfiction works based on artists or idols in the form of diverse writings, Idols and artists are used as visualizations and inspirations although sometimes the author also makes his own groove or character, when the writing rises to the top of trending and get a lot of attention then book publishers are now starting to glance at the existence of twitter fanfiction so that initially the fanfiction is only for entertainment then now it begins to be commercialized in the form of physical books. However, the problem that there are many authors and publishers do not pay attention to the ethics of doing business or the rules or laws that apply related to copyright and intellectual property rights reflected from promotion to the creation of physical books still associate the visuals and names of famous artists or idols so as to indirectly increase the price figure and the number of enthusiasts.
PEMBELAJARAN TEAM GAME TOURNAMENT BERBANTUAN MEDIA NUMBER CARD UNTUK MENINGKATKAN KEAKTIFAN SISWA
Authors: Sani Zulaikha Marta , Sudarmin Sudarmin , Nurhayati Sri
Published: April 2023

Penelitian ini bertujuan untuk meningkatkan keaktifan siswa kelas XI IPA 3 SMA N 9 Semarang melalui pembelajaran Team Game Tournament berbantuan media Number Card. Penelitian ini merupakan penelitian tindakan kelas dengan tipe kolaboratif. Penelitian dilakukan pada tanggal 17 April – 15 Mei 2015. Penelitian dilakukakan dalam tiga siklus. Siklus I terdiri dari enam jam pelajaran, siklus II terdiri dari tujuh jam pelajaran, dan siklus III terdiri dari enam jam pelajaran. Terdapat enam aspek keaktifan yang diamati dalam penelitian ini. Siswa dapat dikatakan aktif apabila minimal empat dari enam aspek yang diamati memperoleh minimal kategori “baik”. Pada siklus I terdapat 85,7% dari jumlah siswa yang sudah dapat dikatakan aktif, sedangkan pada siklus II dan siklus III persentase jumlah siswa yang dapat dikatakan aktif mencapai 100%. Berdasarkan hasil analisis tersebut disimpulkan bahwa pembelajaran Team Game Tournament berbantuan media Number Card dapat meningkatakan keaktifan siswa kelas XI IPA 3 SMA N 9 Semarang.This research aims to increase the activity of class XI IPA 3 SMAN 9 Semarang through Team Game Tournament assisted Number Card learning media. This research is a type of collaborative classroom action. The study was conducted on 17 April - 15 May 2015. The study was conducted in three cycles. The first cycle consists of six hours of lessons, the second cycle consists of seven hours of lessons, and the third cycle consists of six hours of lessons. There are six aspects of the activity observed in this study. Students can be said to be active when at least four of the six aspects of the observed obtains at least "good" category. In the first cycle, terdapat 85,7% of the number of students who can already be said to be active, while in the second cycle and the third cycle the percentage of students who can be said to be active up to 100%. Based on the results of the analysis concluded that Team Game Tournament assisted Number Card learning media can increase the activity of class XI IPA 3 SMAN 9 Semarang.
Potential of Soundproof Wallpaper Based on Indigenous Materials
Authors: Hidayati Rahmanisa Nur , Wulan Dewi Candra , Fauziah Amalia , Rahayu Ngesti , Subali Bambang
Published: April 2023

Noise exposure can occur at any time and interfere with a person's psychological and biological condition. Alternative materials from banana midrib and soybean dregs can be used as sound absorbers based on their characteristics and abundance. This research aims to analyze the optimal composition for sound-absorbing composite materials from banana midrib and soybean dregs and the effect of adding a layer of varnish to its absorption capacity. The method includes the manufacture of the sample, the impedance tube, the box acoustic approach, and the CCD test. The drying process of banana midrib is divided into two types, namely those that are dried in the sun and oven with the banana midrib having gone through a 5% NaOH immersion process before drying. The application of varnish on the sample used the cold spray technique so the layer is not thick and provides durability and resistance to the sample. The impedance tube was carried out to analyze the value of the sound absorption coefficient of the sample at several frequencies which were then averaged. After being tested with the box acoustic approach, the sample has the ability to reduce sound when applied to the walls of the room with an average percentage decrease of 10.84%. Through the CCD test, it is known that the size and number of pores distribution affects the sound absorption capacity. Banana midrib and soybean dregs can be used as an alternative to sound absorbers with the average value meeting the ISO 11654 standard, which is 0.15.
The Challenge of Pancasila in the Development of the Millennial Generation
Authors: Masruri Masruri
Published: April 2023

Pancasila has grown and developed as the nation's ideology since the beginning of independence. And become a noble value for Indonesia as well as a unifying basis for the nation. It contains divine, humanitarian, unifying and democratic values that build social welfare. These fundamentals have built Indonesia to its present day. The millennial generation as the nation's next generation must be able to preserve and maintain the integrity of the values contained in Pancasila, lest the values of Pancasila just disappear without a trace. Various challenges must be able to be resisted, must be able to be conquered. The millennial generation must be able to prove that they are a generation that can be proud and can be trusted to carry a heavy burden towards a better Indonesia. In the current era, the value of Pancasila has begun to be forgotten by the millennial generation, they are more influenced by foreign cultures because they think that foreign cultures are more relevant to today's life. In this era, the development of science and technology and foreign culture is very easy to spread through online media for the consumption of the millennial generation, including the influence of radicalism and intolerance. Thus it is easy and poisons the soul of Pancasila. This is where we are tested how to continue to uphold Pancasila as an up-to-date ideology of the times, how to practice Pancasila in the modern era. In order for the millennial generation to continue to have a Pancasila foundation, an understanding of Pancasila ideology is needed, this can be obtained through formal, informal education and in everyday life.
Corruption, Corruptors, Indonesia, and Pancasila: Various Current Views
Authors: Hilsania Safa Agrita
Published: April 2023

Corruption is one of the problems that is very difficult to overcome in Indonesia. Since the reign of President Sukarno, who was the first president of Indonesia, corruption has been happening so much that corruption in Indonesia is no longer a secret. When there is someone who is found to do corruption, many television stations and news preach everything about corruption that is happening. Because corruption in Indonesia is very common, this results in most people assuming that corruption is no longer a violation of the law, but as a habit. In addition, it also causes the corruptors, or someone who commits corruption, is not ashamed to commit a corruption act. In fact, they know that corruption is a criminal offence that violates the law and has the values of Pancasila. Because the law has not been able to prevent the corruptors not to commit acts of corruption, the enforcement of the values of Pancasila that has been ruled out needs to be reestablished, because besides being the basis of the country, Pancasila is also a state of ideology that has a source of anti-corruption values that will make people shy to commit corruption.