bluuebunny/crossref_metadata_2025 huggingface dataset:
Аксиологическое осмысление культуры и мировоззрения фризского народа сквозь призму паремиологии
Authors: Воевудская О. М.
Published: October 2020

Предметом исследования в данной работе является паремиологический фонд фризского языка, изучение которого до настоящего времени в России не проводилось. После выхода в свет «Фризско-английского словаря» А. Дийкстры [2000] у автора данной работы возникла идея воспользоваться английским языком как посредником при переводе фризских паремий на русский язык с целью последующего составления фризско-русского словаря пословиц и поговорок. Методом сплошной выборки из вышеупомянутого лексикографического источника было извлечено около 200 фризских пословиц и поговорок. Затем был дан дословный перевод каждой паремии с фризского на русский и подобран ее русский аналог, а также синонимы, если таковые имеются. Все паремии были распределены по разделам, группам и подгруппам в соответствии с системно-логической классификацией Г. Л. Пермякова. В результате был получен материал для аксиологического анализа. Проведение этого анализа имело целью осмысление культуры и мировоззрения фризского народа, а также выявление системы его базовых ценностей. Анализ фризских пословиц и поговорок позволил сделать некоторые предварительные выводы. Система ценностей фризского народа, отраженная в их паремиологическом фонде, даже в первом приближении, выглядит весьма сбалансированной: фризы стремятся избегать однозначных и резких оценок, стараются находить не только плохое, но и хорошее в любом человеке, вещи или ситуации; им свойственна определенная компромиссность, взвешенность, сдержанность, стремление к гармонии с внешним миром и самими собой. Полученные результаты могут оказаться полезными в сравнительном изучении паремиологических фондов германских языков, в разного рода аксиологических исследованиях.
Выявление системных правовых ограничений цифровизации государственного управления: текущее состояние и перспективы
Authors: Южаков Владимир Николаевич , Ефремов Алексей Александрович
Published: October 2020

В статье, подготовленной на основе научно-исследовательской работы, выполняемой в рамках государственного задания РАНХиГС, рассмотрены существующие нормотворческие и управленческие подходы к выявлению и устранению правовых ограничений цифровизации государственного управления. Предложены оценка современного состояния ее решения и рекомендации по коррекции реализуемых в настоящее время подходов к решению этой задачи.
Сквозной подход в контексте фактического права на доходы в российском налоговом праве
Authors: Демин Александр Васильевич , Николаев Алексей Викторович
Published: October 2020

Авторы анализируют генезис сквозного подхода в контексте фактического права на доходы в налоговом праве России. Сделан вывод о том, что на текущий момент развитие сквозного налогообложения в контексте фактического права на доходы в российском налоговом праве привело к расширению его применения на все виды трансграничных доходов, облагаемых у источника в РФ, но ряд проблем его применения остаются не урегулированными.
Правовые основы применения и практики внедрения искусственного интеллекта при осуществлении судебного контроля
Authors: Ширеева Екатерина Валерьяновна
Published: October 2020

Рассматриваются вопросы правового регулирования и практик внедрения искусственного интеллекта при осуществлении судебного контроля в зарубежных странах и Российской Федерации. Выявлены на основе «лучших зарубежных практик» основные формы использования искусственного интеллекта в указанной сфере. Сформулированы перспективы и проблемы их внедрения в российскую правовую действительность при осуществлении судебного контроля. На основе анализа зарубежного опыта разработан примерный план внедрения технологий искусственного интеллекта при осуществлении судебного контроля.
The Next Pharmaceutical Path: Determining Technology Evolution in Drug Delivery Products Fabricated with Additive Manufacturing
Authors: Mancilla-de-la-Cruz Jessica , Rodriguez-Salvador Marisela , Ruiz-Cantu Laura
Published: October 2020

Additive manufacturing (AM) is increasingly gaining a presence in the pharmaceutical industry, specifically in the reconfiguration of drug delivery systems wherein new products are being developed for administering pharmaceuticals inside the body, and drug testing systems wherein complex tissues are created to analyze medical treatments. This paper proposes a novel methodology of Competitive Technology Intelligence (CTI) to uncover the evolution of new drug delivery products where additive manufacturing is present. Using the multiple linear regression analysis and hype cycle model as a conceptual basis, we processed data from scientific papers and patents indexed by Scopus and PatSnap for the period of 2004–2019. The outcomes of this study can create a relevant knowledge base for decision-making on introducing novel technologies such as AM. Industrial and academic communities are devoting important efforts toward the advancement of AM in the health industry, especially pharmaceuticals. It is expected that this technology will bring new solutions to address fundamental global health problems. However, this technology is still in its very early stage. Therefore, investments should focus on research and development (R&D) to build a solid foundation for commercialization in the next decade.
Alfabetización climática en la formación inicial y continua de docentes
Authors: Lopera Pérez Marisol , Villagrá Sobrino Sara
Published: October 2020

El cambio climático es un asunto relevante en la actualidad, puesto que en todos los contextos se considera ineludible responder a las emergentes tensiones y problemáticas asociadas. Así que, esta investigación educativa derivada de una tesis doctoral, está fundamentada en la alfabetización climática de docentes en formación inicial y continua, a través del diseño e iteración de un modelo, desde donde se llevaron a cabo experiencias de formación en la Universidad de Valladolid (España) y a través del Centro de Formación del Profesorado e Innovación Educativa (CFIE, Valladolid). El proceso se entiende como una investigación basada en diseño, la cual tuvo como punto de partida la revisión sistemática de la literatura que permitió el diseño de un nuevo modelo y su posterior iteración. Los resultados están enmarcados en dos categorías de análisis: alfabetización climática y profesionalización docente. En relación con la primera, se destaca que los hallazgos visibilizan los conocimientos que los participantes tenían sobre el cambio climático y su reestructuración a partir de la conexión entre diferentes áreas, además, se valoran las actitudes emocionales, cognoscitivas y conductuales. Con respecto a la profesionalización docente, los resultados dan cuenta de una aproximación a diferentes estrategias de enseñanza y aprendizaje susceptibles de aplicar en su práctica como docentes.
Formação de Professores de Ciências no Brasil e Alfabetização Científica: desafios e Perspectivas
Authors: Fontoura Helena Amaral , Pereira Elienae Genésia Corrêa , Figueira Sandro Tiago
Published: October 2020

O presente trabalho traz uma reflexão sobre o conceito de alfabetização científica e sua importância no ensino de Ciências. Para tal, discute processos formativos de docentes da área, com base em autores importantes para sua compreensão, trazendo uma base conceitual sólida para discutir a questão principal. Uma densa revisão de literatura consubstancia as posições refletidas, quais sejam: a importância de esclarecer o conceito de alfabetização científica, sua articulação com a formação de professores de Ciências, e o desafio de pensar uma relação de ensino-aprendizagem que seja referenciada na superação de um paradigma tradicional que não articule os desafios da vida moderna e que traga perspectivas para uma educação de qualidade e que desenvolva o pensamento científico, a cidadania, a vida em cooperação e uma sociedade mais justa, que cuide do ambiente em que vive e contribua para a superação das desigualdades sociais. Pensar uma didática de ciências que se apodere das tecnologias sem deixar a dimensão humana e social é desafio que se apresenta para professores e alunos em processo de se alfabetizarem cientificamente.
Una experiencia de práctica pedagógica con docentes en formación en ciencias naturales apoyada en el aprendizaje basado en proyectos (ABPy)
Authors: Giraldo Macías Christian Fernney , Caballero Sahelices María Concesa , Meneses Villagrá Jesús Ángel
Published: October 2020

En este trabajo se presenta una propuesta alternativa de formación de maestros, fundamentada en la estrategia pedagógica Aprendizaje Basado en Proyectos (ABPy), la Teoría del Aprendizaje Significativo (TAS) y las características esenciales para el diseño de proyectos propuestas por el Buck Institute for Education (BIE). Pretende acercar a los maestros en formación a un escenario de práctica profesional que responda a sus intereses particulares y les permita generar propuestas innovadoras que promuevan aprendizaje significativo en los estudiantes. La propuesta se implementó dentro del programa de Licenciatura en Educación Básica con énfasis en Ciencias Naturales y Educación Ambiental, adscrito a la Universidad de Antioquia, Colombia. Los proyectos realizados por los maestros en cuatro Instituciones Educativas, se analizaron mediante una metodología cualitativa, tipo estudio de Casos. Se han podido constatar las dificultades de los maestros durante el proceso de planificación y ejecución de los proyectos, así como, una apropiación conceptual de los referentes teóricos al finalizar el proceso formativo. Esta propuesta ha sido sometida y aprobada en una convocatoria pública y forma parte de las investigaciones de una tesis doctoral, con énfasis en ABPy, adscrita a la Universidad de Burgos, España.
Smart Villagers as Actors of Digital Social Innovation in Rural Areas
Authors: Zerrer Nicole , Sept Ariane
Published: October 2020

Digital social innovation (DSI) is commonly associated with cities. However, DSI is not limited to urban space. In rural areas, it is the inhabitants themselves who start and push digitalization projects, and collaborate with professional actors from the outside. These innovators see digitalization as a chance to solve rural problems such as scarce mobility, declining community interactions, demographic change, or urban-rural digital divide. In consequence, DSI such as smart community centers, digitally managed car-sharing, or community apps also emerge in rural areas. The article seeks to better understand the different actors responsible for the rural digitalization processes. Based on interviews, document analyses, and field notes, the article focuses on two cases in rural Germany: Wesedun is part of a regional digitalization project empowering villagers to evolve own ideas, and Wokisrab shows off a bottom-up driven digitalization strategy. Both villages are aiming to improve the quality of life. Indicated by these cases and inspired by literature on social innovation, the actor groups are identified as drivers, supporters, and users. Based on the interactions and collaborations of these groups, we introduce Smart Villagers, the bottom-up actors of rural DSI. In order to design governance processes, the results indicate that even though Smart Villagers are motivated, skilled and engaged, they want and need the support of professional actors from the outside.
Professional Knowledge and Teacher's Reflections in Teaching a Situation Involving the Idea of Proportionality
Authors: Garcia Silva Angélica Fontoura , Lopes Sandra Cristina , Galvão Maria Elisa Esteves Lopes
Published: October 2020

Context: Study groups of teachers who meet to reflect on the teaching of mathematics constitute potentially a formative process that can foster teachers' professional knowledge . Objectives: This investigation brings results on the development of professional knowledge of a teacher who delves into ideas related to the concept of proportionality and her teaching during her participation in a study group. Design: The research is of a qualitative nature. Environment and participants: The research was carried out within a study group formed at the school the teacher works, involving seven educators, including teachers and researchers. Data collection and analysis: Data were collected through direct observations, recordings of two study sessions and the development of a class. Observations and reflections on the teaching practice are collected during group studies, based on Zeichner and Ball, Thames and Phelps were analyzed. Results: Their experiences enabled the teacher to expand significantly the knowledge base about the situation presented, and fostered her reflections on the theme and her teaching, especially regarding the resolutions the students presented. Conclusions: The analysis of the process reveals that the proposal to solve problems related to the ideas of proportionality and the analysis of the way students work in the classroom to solve them brings a new meaning to the teacher's knowledge, helping teacher to become more confident to intervene constructively in the students' learning process.
Construction of Mathematical and Financial Concepts based on Realistic Mathematics Education
Authors: Ferreira Susana Machado , Bisognin Vanilde
Published: October 2020

Context: This article presents the excerpt of a qualitative Doctorate in Science and Mathematics Teaching research. Objectives: To describe the results of a study carried out with students from an initial teacher training course. Design: From the development of a didactic sequence, a connection was sought between the ideas of Financial Education anchored by Realistic Mathematics Education (RME). Environment and participants: The study was conducted with 11 students from a Pedagogy course at a Brazilian university. Data collection and analysis: The data were collected through written records of the activities performed by the students, the observations of the classes, and the audio and video recordings. The methodology of analysis was defined considering the procedures of Content Analysis, using the modality of thematic analysis that occurs in three phases: pre-analysis, exploration of the material and treatment of the results. Results: The discussions of the problem situations developed according to the principles of RME, aroused in the students interest, curiosity, autonomy, cooperation and reflection on financial situations, showing that this approach contributed in a significant way, with the development of the didactic sequence. Conclusions: This study shows that by teaching mathematics from everyday contexts, several benefits can be achieved, such as motivation and interest to learn mathematics, and by understanding mathematical concepts, students will be able to use them for the organization of their financial life, and in a conscious, responsible and autonomous way, improve their quality of life.
CIVIL SOCIETY AND DISASTER MANAGEMENT: CASE OF MARMARA EARTHQUAKE
Authors: Ertan Gunes
Published: October 2020

Despite the abundance of studies on performance of public organizations involved in the disaster management system of Turkey, there had been limited attention to the role of civil initiatives involved in disaster management. The disaster response operations in the aftermath of the Marmara earthquake showed that the interaction between public organizations and civil society organizations, and the coordination among the civil society organizations themselves have been very limited. After reviewing the literature on interorganizational response systems following the Marmara Earthquake, this study uses a novel data set to decipher the collective action problems of civil society organizations in Turkish disaster response system using network analysis. The study concludes with a set of policy recommendations to enhance coordination and cooperation among organizations involved in the governance of Turkish disaster management system.
A SECTORAL AND REGIONAL BENCHMARKING STUDY WITH THE DIMENSIONS OF LEARNING ORGANIZATION QUESTIONNAIRE (DLOQ) SCALE MEASUREMENTS
Authors: Tuncalı Yaman Tutku
Published: October 2020

The aim of benchmarking studies is to enable the
relevant sector professionals to identify gaps in the performance of the
organization. Thus, they can provide a more objective perspective for them to
gain competitive advantage. The aim of this study is to collect the criterion
values ​​of the Dimensions of the Learning Organization Questionnaire (DLOQ) in
terms of being a learning organization for the model of Watkins & Marsick
(1993) which was created to measure the performance of organizations. In this
context, in the last decade, academic articles with the keyword “DLOQ” were
scanned. Finally, 40 articles were used to calculate the total comparison
score. As a result, benchmarking figures were obtained on a sectoral and
regional basis and an evaluation was made on a sample application
ULAŞIM VE TİCARET COĞRAFYASI AÇISINDAN İSTANBUL LİMANLARI
Authors: Koldemir Birsen , Kahraman Cengiz
Published: October 2020

Limanlar, geçmiş çağlardan bu yana bulunduğu şehirlerin
ekonomik gelişiminde çok önemli işlevler üstlenmiş ticari ve sosyal
ünitelerdir. Bir liman şehri olan İstanbul’un ticari ve beşeri hayatında
denizyolu ulaştırmasının dolayısıyla limancılığın ayrı bir yeri vardır. Tarihsel
süreçte, -sırasıyla- Roma, Bizans ve Osmanlı İmparatorluğu gibi büyük
medeniyetlere başkentlik yapan İstanbul, coğrafi ve stratejik konumu nedeniyle
dünya ticaretinde her zaman önemli merkezlerden biri olmuştur. Asya ile
Avrupa’yı birbirine bağlayan, Akdeniz-Ege-Karadeniz aksında kritik ve
alternatifsiz bir geçiş olan doğal bir boğaza sahip olan İstanbul; tarih
boyunca doğal bir liman olma işlevini sürdürmüştür. İstanbul’un çok yönlü
hinterlandı ve dağıtım özelliği, hem Karadeniz Havzası hem de Ege/Akdeniz
Havzası’na açılan bir liman şehri olmasını sağlamıştır. Bu çalışmada İstanbul
il sınırları içerisinde günümüzde faaliyet gösteren ticaret ve yolcu limanları fonksiyonlarına
göre sınıflandırılmış, İstanbul ve Marmara alt bölge limanları, ulaşım ve
ticaret coğrafyası açısından değerlendirilerek, İstanbul bölgesi kaynaklı
ithalat ve ihracat verileri incelenmiştir. Diğer taraftan, bölgenin ticaret
yolları perspektifinde limanların sektörel gelişimleri için önerilerde
bulunulmuştur
FEN VE TEKNOLOJİ/FEN BİLİMLERİ DERSİNDE TAHMİN ET-GÖZLE-AÇIKLA YÖNTEMİ İLE DESTEKLENMİŞ YANSITICI DÜŞÜNMEYE DAYALI ETKİNLİK UYGULAMALARININ BAŞARI, KALICILIK, MADDE VE DEĞİŞİM ÖĞRENME ALANINA YÖNELİK TUTUM, BİLİMSEL SÜREÇ BECERİLERİ VE AKADEMİK RİSK ALMA DAVRANIŞLARINA ETKİSİ
Authors: Öner Sunkur Meral , Arıbaş Sebahattin
Published: October 2020

Bu araştırmada, Tahmin Et-Gözle-Açıkla Yöntemi İle Desteklenmiş Yansıtıcı Düşünmeye Dayalı Uygulamaların Milli Eğitim Bakanlığı tarafından önerilen etkinliklere göre 7. sınıf Fen ve Teknoloji dersinin “Maddenin Yapısı ve Özellikleri ” ünitesinde çeşitli öğrenme ürünlerine etkisi incelenmiştir. Araştırmada kontrol gruplu öntest-sontest deseni kullanılmıştır. Araştırmanın çalışma grubunu, 2010-2011 eğitim-öğretim yılında Diyarbakır ili Bağlar ilçesinde bulunan bir ilköğretim okulu 7/A ve 7/B sınıflarına devam eden öğrenciler oluşturmaktadır. Araştırma sekiz hafta sürmüş, deney grubunda Tahmin Et-Gözle-Açıkla Yöntemi İle Desteklenmiş Yansıtıcı Düşünmeye Dayalı Uygulamaların (TGA formu, öğrenme yazıları, anlaşmalı öğrenme, amaçlı grup tartışmaları, kendine soru sorma, kendini değerlendirme), kontrol grubunda ise Milli Eğitim Bakanlığı tarafından önerilen etkinlikler uygulanmıştır. Araştırma sonucunda, 7. sınıf Fen ve Teknoloji dersinin “Maddenin Yapısı ve Özellikleri ” ünitesinde Tahmin Et–Gözle–Açıkla (TGA) Yöntemi İle Desteklenmiş Yansıtıcı Düşünmeye Dayalı Etkinliklerin uygulandığı deney grubu ile Milli Eğitim Bakanlığı tarafından önerilen etkinliklerin uygulandığı kontrol grubu karşılaştırıldığında; başarı, kalıcılık, Madde ve Değişim öğrenme alanına yönelik tutum, bilimsel süreç becerileri ve akademik risk alma davranışları puanları arasında deney grubu lehine anlamlı fark vardır. Elde edilen bulgular ilgili literatür ışığında tartışılmıştır.
TRANSLATION, ADAPTATION, VALIDITY AND RELIABILITY OF THE SENSE-MAKING SCALE: A CROSS-CULTURAL EVIDENCE FROM INDIA, MALAYSIA, ROMANIA AND TURKEY
Authors: Tuğsal Türker
Published: October 2020

The main object of this research is translation, adaptation, validity and reliability of the Sense-Making Scale’s Turkish version to English so as to be used in cross-cultural researches. Even though there are extensive studies which have been carried out on sense-making, any sense-making scale or questionnaire in the existing literature is not consistent and there is a gap that should be filled. The contribution of this research is to redound a sense-making measurement tool in English. Firstly, the related literature is reiterated and a pilot study of translated scale is applied for validity and reliablity. After reliability is assured, the surveys are sent to 600 academicians in India, Malaysia, Romania and Turkey and 466 of the data are valid. The data fit to normal distribution. Cronbach's Alpha value is found reliable (0.763) and the variability of the scale is 61.257%. The first possible explanation for these results is being the first measurement tool about sense-making in English. The second implication of the study is; sense-making of signs such as action, discourse, diagnosis, facts orelse events may let people prevent from adverse, negative and unfavourable incidents such as accidents, chaoses or crises which may occur in times to come.
REGIONAL TALENT MANAGEMENT IN THE CONTEXT OF UNIVERSITY-INDUSTRY COOPERATION: A MODEL PROPOSAL
Authors: Ahat Kamil , Koyuncuoğlu Özdal
Published: October 2020

Qualified human resources and management of the human resource stand out as critical values in terms of the country’s economy and future in the age digital transformation and they are also important within university-industry cooperation and social contribution responsibilities which are both on the agenda of Turkish Republic Presidential Human Resources Office and universities. The expression of “qualified human resources” frequently expressed by those working in fields such as labor and employment is the basis of a country’s struggle for existence rather than competition. This study holds the potential to improve its success by supporting the application of yetenekkapisi.org implemented by Turkish Republic Presidential Human Resources Office and bringing student and graduate candidates with employers and universities together. It also introduces the regional talent management application model developed in the context of university-industry cooperation within the framework of talent management literature in human resources. Therefore, the study aims to present a permanent, sustainable model proposal integrating the practice with the scientific theoretical infrastructure that focuses on developing the strategy of regional development and assessment of competencies. It is proposed to develop the strategic management plan for developing and assessing regional competencies, as well as to attract, identify, develop and retain the skills needed by the region through the developed model. In the first part of the study, talent management, talent management process, applications and tools are explained within the historical development process, and in the second part the developed regional talent management implementation model is presented. The last part of the study includes suggestions for future studies.
Model of a Rehabilitation and Educational Space for Children with Disabilities
Authors: Voitas S.A. , Zholud A.N. , Kabanov I.S. , Brazhnik Y.V. , Ribelka I.V.
Published: October 2020

The article is devoted to the current problem of rehabilitation and adaptation of children with disabilities in society. This article discusses a unique rehabilitation assistance program for children with disabilities under the age of 18. The characteristic features of this approach are identified and described that help to overcome the main difficulties that not only children but also their parents face. The goal of the program is the socialization of children and adolescents with various disabilities and improving their quality of life in general. As a result of the program, social integration of minor children into society and the harmonization of their relations with themselves and other people are carried out. Such a look at the issue of rehabilitation will be of interest to specialists in the field of psychology, medicine and pedagogy.
Formación académica e injusticia epistémica en médicos residentes de primer año
Authors: Acosta-Fernández Martín , Aguilera-Velasco María de los Ángeles , Pozos-Radillo Blanca Elizabeth , Parra Osorio Liliana
Published: October 2020

Introducción: La formación de residentes es un proceso académico complejo, profesores y estudiantes protagonizan una relación altamente jerarquizada proclive a injusticias epistémicas.

Objetivo: Conocer la exposición de residentes de primer año a situaciones de injusticia epistémica y posibles agravios como sujetos de conocimiento.

Método: Análisis temático a 31 residentes. Muestreo propositivo. 55 entrevistas en profunidad, tematización inductiva y codificación deductiva. Análisis de datos mediante Atlas.ti® v.8.4.3.

Resultados: Escenario de poder y posición de poder fueron la temática y sub-temática más recurrentes. Las experiencias de agravio se manifestaron mediante el silenciamiento y opresión epistémica.

Conclusiones: Los residentes entrevistados enfrentan situaciones de injusticia epistémica y se refleja en actos de agravio contra su persona.
PTERJİUM CERRAHİSİ İÇİN NEDEN BEKLENİR?
Authors: Doğan Mustafa , Sabaner Mehmet Cem , Özdamar Esma Norman , Yavaş Güliz Fatma , Duman Reşat
Published: October 2020

AMAÇ: Pterjium cerrahisi yapılan hastalarda ameliyat zamanını etkileyen faktörleri bulmak ve alınabilecek önlemleri tespit etmek amaçlanmıştır.GEREÇ VE YÖNTEM: Ocak 2014-Şubat 2017 arası kliniğimizde pterjium nedeniyle cerrahi yapılan 53 hastanın 53 gözü çalışmaya alındı. Hastaların bilgileri, ameliyatı bekleme sebepleri ve cerrahi öyküsü sorgulandı. Hastaların cevaplarına göre gruplandırma yapıldı: Hastalığını bildiği halde çok fazla rahatsızlık duymamak (grup 1), hastalığının farkında olmamak (grup 2), ameliyat olmak için pterjiumun biraz daha ilerlemesini beklemek (grup 3), pterjium cerrahisi daha önce geçirip yine tekrarlamasından endişe etmek (grup 4) ve ameliyattan korkmak (grup 5).BULGULAR: En çok karşılaşılan pterjium ameliyatı geciktirme nedeni; hastalığını bildiği halde çok fazla rahatsızlık duymamak idi. İkinci sırada ise, ameliyat olmaktan korkmak olduğu tespit edildi. Cerrahiyi geciktirme nedenleri dağılımı şu şekilde idi: 1.Grup 23 (%43.4), 2.grup 8 (%15.09), 3.grup 8 (%15.09), 4.grup 4 (%7.55), 5.grup 10 (%18.87) hasta.SONUÇ: Pterjiumda hasta kaynaklı ameliyat zamanı gecikmesinin ameliyat başarısını ve sonuçlarını etkileyebileceği, yapılacak ameliyatla ilgili hastaların bilgilendirilmesi, hastaların endişelerinin giderilmesinde psikolojik-sosyal destek verilmesi ameliyat olma zamanında gecikmeleri önleyebilir.
PERİODONTAL SAĞLIĞIN İN VİTRO FERTİLİZASYON SONUÇLARI ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ
Authors: Altaş Nurcan , Uslu Toygar Hilal , Cilasun Ülkem , Kumbak Aygün Banu , Demir Becen
Published: October 2020

AMAÇ: Bu çalışmanın amacı sistemik sağlık üzerinde etkisi kanıtlanmış olan periodontal durumun infertil kadınlarda uygulanan in vitro fertilizasyon tedavisi sonuçları üzerindeki etkisini değerlendirmektir.
GEREÇ VE YÖNTEM: İnfertilite tanısı konmuş kadın hastalardan sosyodemografik veriler bir anket yardımıyla toplanmıştır. Kan testi gününde plak indeksi, gingival indeks, cep derinliği, sondalamada kanama indeksi ölçümleri yapılmıştır. Buna göre; sağlıklı, gingivitisli ve periodontitisli olarak sınıflandırılan hastalar ile kullanılan human chorionic hormon gonadotropin (hCG) dozu, östradiol ve progesteron seviyeleri, transfer edilen embriyo sayıları, oosit sayıları ve gebelik sonuçları karşılaştırılmıştır. Çalışmada, tek yönlü ANOVA, Tukey HDS, Tampane’s T2, Kruskal-Wallis, Mann-Whitney U ve ki-kare testleri kullanılmıştır.
BULGULAR: Gruplar arasında oosit sayıları, transfer edilen embriyo sayıları ve gebelik sonuçları açısından bir farklılık gözlenmemiştir. Gruplar arasında hCG günü östradiol seviyesi açısından bir farklılık gözlenmemesine karşın hCG günü progesteron seviyesi periodontitis grubunda sağlıklı ve gingivitisli gruba göre anlamlı şekilde yüksek bulunmuştur.
SONUÇ: Periodontitis grubunda gözlenen progesteron seviyesindeki yükselme IVF sonucunu etkileyebilecek olan eşik değerin altındadır. Periodontal durumun infertilite tedavisi üzerindeki etki mekanizmasının belirlenmesi için geniş ölçekli ve uzun vadeli çalışmalara ihtiyaç duyulmaktadır.
Октэра «Изида» (к исторической интерпретации иконографического памятника III в. до н. э. из боспорского города Нимфея)
Authors: Писаревский Николай Петрович
Published: October 2020

Открытая при раскопках храма Афродиты в Нимфее фреска с изображением гребного корабля «Изида» вплоть до настоящего времени остаётся предметом дискуссий, в контексте которых поднимаются самые различные вопросы. Их амплитуда включает как датировку иконографического памятника, так и аспекты, имеющие прямое отношение к морской истории Боспорского царства вообще, военному флоту Спартокидов и их талассократии на Понте Эвксинском, в частности. Тщательное изучение основных узлов конструкции на изображении корабля, моделирование основных размерений и пропорций корабельного корпуса позволяет выявить величины, вполне сопоставимые c памятниками античных кораблекрушений и находками отдельных элементов конструкции боевых эллинистических кораблей. Это позволяет с привлечением имеющихся фрагментарно-эпизодических и немногочисленных данных античной традиции, а также с учётом всей совокупности окружающих «Изиду» изображений других морских судов и разновременных граффити обосновать заявленный в названии тезис, предложив датировку отображённого на фреске исторического события – 288 г. до н. э.
Features of intravital renal topography in various patient’s positions on the basis of multislice computed tomography findings
Authors: Lyashchenko S. N. , Demin D. B. , Urazov D. F.
Published: October 2020

The aim of the study is to investigate changes in the renal topography in the supine and lateral position of the patient in order to further improve the preoperative planning of laparoscopic operations in kidney masses.

Material and methods. The study included 35 patients with a simple renal cyst, who underwent computed tomography in the supine position and on the healthy side (operating position). To assess the topography, the authors have proposed the following coordinate system: on axial computed tomograms performed with the patient in the supine and lateral position, the OY axis was drawn across the spinous process and the middle of the vertebral body, the OX axis was perpendicular, and went across the most posterior point of the spinal foramen. CT-grams were assessed using RadiAnt DICOM Viewer program.

Results. The study defined morphometric features of the renal displacement medially and anteriorly, as well as cranially or caudally. There was a greater mobility of the left kidney compared with the right kidney. The least mobile was the upper third of the kidney on each side, the middle third of the kidney was more mobile at the level of the hilum, and the greatest displacement was noted in the lower third of the kidney. When patients being in the lateral position, the left kidney was more often displaced downward (caudally) – in 83% of cases, the right kidney was equally often displaced cranially (53% of cases) and caudally - 47%. In all cases of the patient's lateral position, the displacement of the kidney was accompanied by deformation of its vascular pedicle.

Conclusion. The data obtained must be taken into account in preoperative planning, when performing laparoscopic kidney surgery.
Morphological study of the retina of WAG/Rij rats with pigmentary degeneration in postnatal ontogenesis
Authors: Musina L. A. , Baigil'din S. S. , Khismatullina Z. R.
Published: October 2020

The aim of the study was to detect morphofunctional features of the retina of WAG/Rij rats during postnatal development from the 1st to the 360th day after birth.

Material and methods. The study included retina of the inbred WAG/Rij rats (60 eyeballs from 30 rats totally) from the 1st to the 360th day of life. Standard histological studies were performed on paraffin sections stained with hematoxylin and eosin. Immunohistochemical method was used to determine the expression of acidic glial fibrillar protein GFAP in the rat retina. Mouse monoclonal antibodies (Santa Cruz Biotechnology) and a universal secondary detection system (NovocastraTM) were used for imaging. The degree of protein expression in the retina of WAG/Rij rats was compared in different age groups.

Results. It was found that after birth, the retina of rat models of the WAG/Rij line is formed in the same way as the retina of rats of other strains and acquires a definitive structure only by the end of the second week (correlates with the opening of the eyes). On the 20th day, the first signs of dystrophic and destructive processes appear in the retina of WAG / Rij rats progressing as they grow older and leading to retinal gliosis. The increase in the expression of acidic glial fibrillar protein GFAP begins from the 30th day and increases with age as destructive processes in the retina increase.

Conclusion. The early postnatal development of the retina of the WAG/Rij rats, which correlates in character with the postnatal retina development of rats of other strains, is interrupted by the launch of destructive processes in the retina soon after its complete differentiation. The further intensifying cascade of degeneration over time leads to the death of retinal neurons and their replacement by glial cells.
Novel histochemical approach for evaluation of tryptase expression in the mast cell population
Authors: Atyakshin D. A. , Gerasimova O. A. , Meshkova V. Yu , Samodurova N. Yu. , Samoilenko T. V. , Shishkina V. V.
Published: October 2020

The paper presents a novel histochemical approach for evaluation of tryptase expression in the mast cell population. To study the selective effect of mast cells (MC) on the parameters of a specific tissue microenvironment, it is necessary to detail the molecular composition of their secretome and analyze the pathways of degranulation. The developed method for combined immunomorphological and histochemical tryptase staining protocols contributes to a more objective determination of the integral level of specific protease expression in the skin MC population. Extra visualization potentials of cytological features and specific aspects of tryptase processing expand efficiency of morphological analysis in both normal and pathological conditions.
Türkiye’de İşletme Tarihinin Görünümü ve Gelişimi: Yönetim ve Organizasyon Kongre Bildirileri Üzerinden Bir Bakış
Authors: EROĞLU Osman
Published: October 2020

Türkiye’de işletme tarihini ayrı bir disiplin olarak nitelendirmek için oldukça erken olmasına rağmen; yakın tarihte dünyada işletme tarihine artan ilgiden etkilenerek bu alan ilgi görmeye başlamıştır. Bu araştırmada işletme tarihinin önce kuramsal çerçevesi ortaya çıkarılmış, daha sonra Google Ngrams istatistikleri aracılığıyla bu alan taranmış̧ ve alanın Türkiye’deki görünümü ve gelişimi 1993 yıllından beri düzenlenen Yönetim ve Organizasyon Kongre bildirileri üzerinden incelenmiştir. Bu çalışmada işletme tarihinin Türkiye’deki yakın bir kesit tanımlaması yapılarak yönetim ve organizasyon yazınına katkı sağlaması beklenmektedir
The Syntheses and Characterization of New Dithiophosphonates derived from Novel 2,4-Bis(methoxytolyl)-1,3-dithia-2,4-diphosphetane 2,4- disulfides and Their Ni(II) Complexes
Authors: SAĞLAM Ertuğrul Gazi , BULAT Elif , YILMAZ Hamza
Published: October 2020

Two new perthiophosphonic acid anhydrides, 2,4-bis(Rx,y)-1,3-dithia-2,4-diphosphetane 2,4-disulfide (Rx=3-methoxytolyle, SAV-B1 and Ry=2-methoxytolyle, SAV-B2) were synthesized. From the reaction of these dimers, (Rx,y‐P(S)S)2, with alcohols and then dry ammonia gas, ammonium salts of the dithiophosphonic acids ((Rx,y)(RnO)PS2H), Rn, R1= ethyl-, R2= 2-propyl-), namely, four new compounds of the type [NH4][S2P(Rx,y)(ORn)] were obtained. The ammonium salts were further reacted with NiCl2.6H2O to prepare four new dithiophosphonato nickel(II) complexes, [Ni(S2P(Rx,y)(ORn))].
The ligands and the complexes were characterized by mass-(ESI), 1H-, 13C-, 31P-NMR, IR-spectroscopy, HSQC techniques and elemental analyses. Complementary structural information was provided by the HSQC spectra of the [NH4][S2P(Rx,y)(OR2)]. The structure of the perthiophosphonic acid anhydrides were deduced from the structures of dithiophosphonates thereof.
MINERALOGY OF SOILS DEVELOPED ON TRIASSIC SEDIMENTS
Authors: Chizhikova N. , Ivanov A. , Kuchmar N.
Published: October 2020

Soils formed on eluvium of Triassic sediments and their derivatives are characterized by a sharp predominance of smectite group minerals with an admixture of palygorskite in the mud fraction and feldspars in dusty ones. The composition of minerals predetermines high soil fertility.
EVOLUTION OF THE HUMUS CLAYEY MATERIAL OF THE CHERNOZEM HORIZON DURING LAND RECLAMATION OF SOLONETZES BY GROUNDING
Authors: Chizhikova N. , Khitrov N. , Cheverdin Yu.
Published: October 2020

Under the influence of the saline process (sodium exchange rate of 5-15% and specific electrical conductivity of the extract from the water-saturated paste ECse < 2 dSm/m) the well aggregated black earth material used for soil reclamation by means of hydromorphous black earth salt complexes starts to turn into a peptized state and is evolutionarily transformed into a texture-differentiated profile of saline soil. Part of the previously aggregated silt passes to the water-performed state and begins to move down the profile from 0-4 cm layer. Water-performed sludge consists of highly ordered complex mixed mica-smektite formations with a high content of smectite packets, hydro-mica, kaolinite, chlorite, as well as highly dispersed quartz. A distinctive feature of the soil surface horizons of the solonetz complex is the increased content of highly dispersed quartz of micron dimension. The composition of mineral components in the aggregated muds remains the same, but the share of hydro-mica increases, and mixed-layer mica-smektites have a more perfect structure due to less disordered structure in crystallites. The share of finely dispersed quartz in the aggregated silt fraction is less than that of water-peptized silt, and is more similar to that of loess-like loess-like loam, which is a soil-forming rock.
The pore space arrangement in podzolic horizons of loamy soils (analysis of 2D AND 3D images)
Authors: Skvortsova E. B. , Gerke K. M. , Korost D. V. , Abrosimov K. N.
Published: October 2020

A comparative analysis of 2D (in thin sections) and 3D (X-ray CT) images allowed obtaining new data about the pore space arrangement in the EL horizon of soddy podzolic soils. The 3D images of the soil mass and the pore space have been made by reconstruction via computer using a great number of 2D shady X-ray projections. It is shown that the EL horizon reveals not only horizontal fissured pores between platy aggregates but also many isolated vesicular pores of unknown genesis. As dinstinct from the podzolic horizon such pores are singly met in the soil-forming mantle loam (C horizon). The major pores with rounded edges are represented by recent and relic root holes. The obtained data serve as an additional information on the podzolic horizon configuration in soddy podzolic soils on the whole and the pore space in these horizons in particular. Thanks to this study iy is reasonable to conclude that the information on genetic differences in the configuration of pedogenic and lithogenic horizons of the soddy podzolic soils is expanded.
Why Blood Group A Individuals Are at Risk Whereas Blood Group O Individuals Might Be Protected from SARS-CoV-2 (COVID-19) Infection: A Hypothesis Regarding How the Virus Invades the Human Body via Abo(H) Blood Group-Determining Carbohydrates
Authors: Arend Peter
Published: October 2020

While the angiotensin converting enzyme 2 (ACE2) protein is defined as the primary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, the viral serine molecule might be mobilized by the host's transmembrane protease serine subtype 2 (TMPRSS2) enzyme from the viral spike (S) protein and hijack the host’s N-acetyl-D-galactosamine (GalNAc) metabolism. The resulting hybrid, serologically A-like/Tn (T-nouvelle) structure potentially acts as a host–pathogen functional molecular bridge. In humans, this intermediate structure will hypothetically be replaced by ABO(H) blood group-specific, mucin-type structures, in the case of infection hybrid epitopes, implicating the phenotypically glycosidic accommodation of plasma proteins. The virus may, by mimicking the synthetic pathways of the ABO(H) blood groups, bind to the cell surfaces of the blood group O(H) by formation of a hybrid H-type antigen as the potential precursor of hybrid non-O blood groups, which does not affect the highly anti-glycan aggressive anti-A and anti-B isoagglutinin activities, exerted by the germline-encoded nonimmune immunoglobulin M (IgM). In the non-O blood groups, which have developed from the H-type antigen, these IgM activities are downregulated by phenotypic glycosylation, while adaptive immunoglobulins might arise in response to the hybrid A and B blood group structures, suggesting the exertion of autoreactivity. The non-O blood groups thus become a preferred target for the virus, whereas blood group O(H) individuals, lacking the A/B phenotype-determining enzymes and binding the virus alone by hybrid H-type antigen formation, have the least molecular contact with the virus and maintain the critical anti-A and anti-B isoagglutinin activities, exerted by the ancestral IgM, which is considered the humoral spearhead of innate immunity.
A Standard Model Mechanism for Inflation
Authors: Hayes Robert
Published: October 2020

This brief work tenets that inflationary genesis can be obtained within the standard model based on only a few general assumptions. These are that the origin began at a singularity of Planck length and that all quantum transitions take place within Planck time units. From these, the subsequent effects from the Pauli Exclusion Principle (PEP) and the uncertainty principle can then give rise to an inflationary origin.
Canine colostrum exosomes: Characterization and influence on the canine mesenchymal stem cell secretory profile and fibroblast anti-oxidative capacity.
Authors: Villatoro Antonio J , Martín-Astorga María del Carmen , Alcoholado Cristina , Becerra José
Published: October 2020

Background:
Canine colostrum milk (CCM) is a specific secretion of the mammary gland that is fundamental for the survival of the newborn. CCM has many described components (immunoglobulins, proteins or fat), but its small vesicles, named exosomes, are largely unknown.

Results:
A characterization of CCM exosomes was performed. Exosomes were abundant in CCM and appeared with the characteristic cup-shaped morphology and well-defined round vesicles. The size distribution of exosomes was between 37 and 140 nm, and western blot analysis showed positive expression of specific exosomal markers. Proteomic analysis revealed a total of 826 proteins in exosome cargo. We also found that exosomes modified the proliferation and secretory profiles in canine mesenchymal stem cells derived from bone marrow (cBM-MSCs) and adipose tissue (cAd-MSCs). Additionally, CCM exosomes demonstrated a potent antioxidant effect on canine fibroblasts in culture.

Conclusions:
Our findings highlight, for the first time, the abundant presence of exosomes in CCM and their ability to interact with mesenchymal stem cells (MSCs). The addition of exosomes to two types of MSCs in culture resulted in specific secretory profiles with functions related to angiogenesis, migration and chemotaxis of immune cells. In particular, the cAd-MSCs secretory profile showed higher potential in adipose tissue development and neurogenesis, while cBM-MSC production was associated with immunity, cell mobilization and haematopoiesis. Finally, exosomes also presented antioxidant capacity on fibroblasts against reactive oxygen species activity within the cell, demonstrating their fundamental role in the development and maturation of dogs in the early stages of their life.
A Novel Computational Model for Predicting Potential LncRNA-Disease Associations based on Both Direct and Indirect Features of LncRNA-Disease Pairs
Authors: Xiao Yubin , Xiao Zheng , Feng Xiang , Chen Zhiping , Kuang Linai , wang lei
Published: October 2020

Background: Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) are closely associated with human diseases, and it is helpful for the diagnosis and treatment of diseases to get the relationships between lncRNAs and diseases. Due to the high costs and time complexity of traditional bio-experiments, in recent years, more and more computational methods have been proposed by researchers to infer potential lncRNA-disease associations. However, there exist all kinds of limitations in these state-of-the-art prediction methods as well.Results: In this manuscript, a novel computational model named FVTLDA is proposed to infer potential lncRNA-disease associations. In FVTLDA, its major novelty lies in the integration of direct and indirect features related to lncRNA-disease associations such as the feature vectors of lncRNA-disease pairs and their corresponding association probability fractions, which guarantees that FVTLDA can be utilized to predict diseases without known related-lncRNAs and lncRNAs without known related-diseases. Moreover, FVTLDA neither relies solely on known lncRNA-disease nor requires any negative samples, which guarantee that it can infer potential lncRNA-disease associations more equitably and effectively than traditional state-of-the-art prediction methods. Additionally, to avoid the limitations of single model prediction techniques, we combine FVTLDA with the Multiple Linear Regression (MLR) and the Artificial Neural Network (ANN) for data analysis respectively. Simulation experiment results show that FVTLDA with MLR can achieve reliable AUCs of 0.8909, 0.8936 and 0.8970 in 5-Fold Cross Validation (5-fold CV), 10-Fold Cross Validation (10-fold CV) and Leave-One-Out Cross Validation (LOOCV), separately, while FVTLDA with ANN can achieve reliable AUCs of 0.8766, 0.8830 and 0.8807 in 5-fold CV, 10-fold CV, and LOOCV respectively. Furthermore, in case studies of gastric cancer, leukemia and lung cancer, experiment results show that there are 8, 8 and 8 out of top 10 candidate lncRNAs predicted by FVTLDA with MLR, and 8, 7 and 8 out of top 10 candidate lncRNAs predicted by FVTLDA with ANN, having been verified by recent literature. Moreover, comparing with the representative prediction model of KATZLDA, comparison results illustrate that FVTLDA with MLR and FVTLDA with ANN can achieve the average case study contrast scores of 0.8429 and 0.8515 respectively, which are both notably higher than the average case study contrast score of 0.6375 achieved by KATZLDA.Conclusion: The simulation results show that FVTLDA has good prediction performance, which is a good supplement to future bioinformatics research.