bluuebunny/crossref_metadata_2025 huggingface dataset:
Dermoscopy and Reflectance Confocal Microscopy in the Diagnosis and Management of Nail Fold Squamous Cell Carcinoma
Authors: Mazzilli Sara ,   Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy.,   Sara Mazzilli, MD Dermatologic Unit, Department of Systems Medicine University of Rome Tor Vergata Viale Oxford 81 Rome 00133, Italy, Cosio Terenzio ,   Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy., Diluvio Laura ,   Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy., Vollono Laura ,   Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy., Gonzalez Salvador ,   Department of Medicine and Medical Divisions, University of Alcalá, Madrid, Spain., Di Prete Monia ,   Anatomic Pathology Unit, University of Rome Tor Vergata, Rome, Italy., Orlandi Augusto ,   Anatomic Pathology Unit, University of Rome Tor Vergata, Rome, Italy., Bianchi Luca ,   Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy., Campione Elena ,   Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy.
Published: November 2022

The management and prognosis of squamous cell carcinoma largely depend on its invasiveness and grade of differentiation. Pigmented nail fold squamous cell carcinoma represents a therapeutic challenge, needing careful treatment to preserve nail function. Here, we report the use of dermoscopy and Reflectance Confocal Microscopy to monitor nail fold squamous cell carcinoma in situ and its response to treatment with topical imiquimod.
Comparing Cooperative Flipped Learning with Individual Flipped Learning in a Biochemistry Course
Authors: Jafarkhani Fatemeh ,   Department of Educational Technology, Faculty of Psychology and Educational Sciences,Allameh Tabataba’i University, Tehran, Iran, Jamebozorg Zahra ,   Department of Educational Technology, Faculty of Psychology and Educational Sciences,Allameh Tabataba’i University, Tehran, Iran,   Jamebozorg, Zahra Department of Educational Technology, Faculty of Psychology and Educational Sciences, Allameh Tabataba’i University Tehran 67145-1619 Iran (the Islamic Republic of). E-mail: jamebozorgzahra@ymail.com
Published: November 2022

The aim of this study was to compare a cooperative flipped learning method with an individual flipped learning method in a biochemistry course. In a quasi-experiment, convenience sampling was employed to select 61 biochemistry students, who were then randomly divided into three groups. The experimental groups were trained separately using the cooperative flipped learning and individual flipped learning methods in seven sessions. The control group was trained using the conventional method. The groups were given teacher-made academic achievement tests, used as pretest and posttest. The ANCOVA test was employed to analyze data. According to the results, the cooperative flipped learning method improved academic performance more than the individual flipped learning method in the posttest scores. The results also indicated that the flipped learning implementation both outside and inside the classroom has effects on learning. In fact, the optimal implementation of flipped learning improves in-depth learning to solve problems and carry out experiments in a biochemistry course.
Oncology Information System: A Qualitative Study to Identify Cancer Patient Care Workflows
Authors: Yazdanian Azadeh ,   Department of Medical Record and Health Information Technology, School of Allied Medical Sciences,Mazandaran University of Medical Sciences, Sari, Iran,   Azadeh Yazdanian,PhD in Health Information Management,Mazandaran University of Medical Sciences, Sari, Iran. E-mail: yazdanian.azade@yahoo.com
Published: November 2022

Oncology information systems provide solutions for managing the information of cancer patients and enable monitoring of different aspects of cancer patient care. Since the use of oncology information systems enhances the quality of care, improves documentation, optimizes resource allocation, and increases the cost-effectiveness of care services, attention to these systems’ performance and their adaptation to workflows seems necessary. The purpose of this study was to identify cancer patient care workflows to design an oncology information system for Iran.

This study employed a qualitative design and was conducted in 2019. Semi-structured interviews were conducted with 25 experts to determine their views on identifying workflows for cancer patients’ care. The participants were clinical and non-clinical staff at six university hospitals equipped with oncology wards. The method of data analysis was framework analysis.

The cancer patient care workflows consisted of two categories, including cancer diagnosis workflows and cancer treatment workflows. Cancer diagnosis workflows fall into three subcategories, i.e., the patient’s referral to the clinic, an examination of the patient’s condition, and pathology workflows. On the other hand, cancer treatment workflows are divided into various treatments offered to cancer patients and workflows in the chemotherapy and radiotherapy wards.

Given the variety of services and the complexity of caring for cancer patients as well as the involvement of various specialists in the process of care, identifying and optimizing workflows in the oncology information system reduces errors, enhances data accuracy, eliminates unnecessary steps, and ultimately improve the service delivery to cancer patients.
Dynamics of Cytokine Profile Indicators Changes in Animals with Acute Generalized Peritonitis on the Background of Diabetes Mellitus
Authors: Dzubanovsky Ihor Yakovych ,   Department of Surgery of Postgraduate Faculty, I. Horbachevsky Ternopil National Medical University, Теrnopil, Ukraine, Pidruchna Svilana Romanivna ,   Department of Medical Biochemistry, I. Horbachevsky Ternopil National Medical University, Теrnopil, Ukraine,   Svitlana Pidruchna Head of Department of Medical Biochemistry,I. Horbachevsky Ternopil National Medical University, Ukraine Voli Square, 1, 46002, Ternopil, Ukraine Phone: +38(098)640-86-27 E-mail: pidruchna@tdmu.edu.ua, Melnyk Natalia Anatoliivna ,   Department of General Hygiene and Ecology, I. Horbachevsky Ternopil National Medical University, Теrnopil, Ukraine, Andreychyn Serhiy Mykhailovych ,   Department of Internal Medicine Propaedeutics and Phthisiology, I. Horbachevsky Ternopil National Medical University, Теrnopil, Ukraine, Vervega Bogdana Mykhailivna ,   Department of Pathological Physiology, I Danylo Halytsky Lviv National Medical University, Lviv, Ukraine, Nychyk Natalia Anatoliina ,   Department of Infectious Diseases with Epidemiology, I. Horbachevsky Ternopil National Medical University, Теrnopil, Ukraine
Published: November 2022

In acute peritonitis, any surgical intervention leads to impaired immune protection with the development of postoperative purulent-septic complications, which increases several times the likelihood of death, especially in people with secondary immunodeficiency as a consequence diabetes mellitus.

We aimed to study the dynamics of pro- and anti-inflammatory cytokine content in rat serum under experimental acute generalized peritonitis on the background of diabetes mellitus.

Fifty-six white rats were used for the study. The determination of the serum cytokine profile was performed by enzyme-linked immunosorbent assay.

When comparing the levels of interleukins between the study groups, a statistically significant increase in the level of proinflammatory cytokines was found in the group of diabetic animals during all experimental periods. In particular, the concentration of interleukin – 1β increased significantly by 94% on day 1 of observation, by 115% on day 3, and by 121% on day 7 compared to the control group. Similarly, a significant increase in TNF-α levels was observed in animals with diabetes. In this group, the most significant increase in the level of TNF-α was recorded on the seventh day of the experiment, and it increased by 3.4 times.

Animals with acute peritonitis on the background of diabetes had a significantly increased concentration of anti-inflammatory cytokines in the serum of all study groups, which confirms their involvement in the pathogenesis of the disease under study.
A Multidisciplinary Approach of an Endo-Perio Lesion in a Severely Compromised Tooth: An 18-Year Follow-up Case Report
Authors: Pereira Ramón ,   Periodontics, Private Practice, Bogotá, Colombia,   Universidad Nacional de Colombia, School of Dentistry, Bogotá, Colombia, Arboleda Silie ,   Unit of Clinical Oral Epidemiology Investigations (UNIECLO), School of Dentistry, Universidad El Bosque. Bogotá, Colombia,   Dr. Silie Arboleda, DDS, Periodontist, Assistant Professor, School of Dentistry, Universidad El Bosque, Bogotá, Colombia.Av. Cra. 9 #131A–02 E-mail: siliesoad@gmail.com
Published: November 2022

This case report describes the diagnosis, multidisciplinary treatment, and long-term follow-up of a severely compromised tooth in a patient who was referred for assessing a gingival recession. Clinical evaluation of the left maxillary canine showed 12 mm of mid-buccal gingival recession, probing depth of 14 mm on the mesial-buccal aspect, and grade III mobility. A periapical radiograph revealed extensive periapical and lateral radiolucency. The first step of the treatment was to carry out oral hygiene instructions and full-mouth debridement. After that, endodontic treatment was performed immediately. Periodontal reevaluation four months after endodontic therapy revealed that probing depths of all sites were within 3 mm and periapical radiograph showed a slight decrease in periapical and lateral radiolucency. It was subsequently decided to perform root coverage with a laterally positioned flap and subepithelial connective tissue graft. Six months after surgery, the root surface showed 1 mm recession, representing root coverage of 91.7% and a gain of attachment of 13 mm. The patient was enrolled in a 6-month supportive periodontal therapy. Treatment outcomes were evaluated over 18 years, with successful radiographic and clinical results throughout the follow-up period. The successful management of endo-periodontal lesions requires an accurate diagnosis, which is imperative to provide proper therapy in the correct treatment sequence.
Alpha-Lipoic Acid as a Means of Influence on Systemic Inflammation in Type 2 Diabetes Mellitus Patients with Prior Myocardial Infarction
Authors: Altunina Nataliia Valeriivna ,   Fourth Department of Internal Medicine, Bogomolets National Medical University, Kyiv, Ukraine,   Altunina Nataliia, PhD in Medical Sciences Fourth Department of Internal Medicine, Bogomolets National Medical University, Kyiv, Ukraine, Ukraine, 01601, Kyiv, 13 T. Shevchenko Blvd.; Phone.: +380509209139; E-mail: alt.nataliia77@gmail.com, Lizogub Viktor Grigorovich ,   Fourth Department of Internal Medicine, Bogomolets National Medical University, Kyiv, Ukraine, Bondarchuk Oleksandr Mykolayovych ,   Fourth Department of Internal Medicine, Bogomolets National Medical University, Kyiv, Ukraine
Published: November 2022

Patients with combined coronary heart disease and diabetes mellitus make up a growing segment of the population and require a com¬prehensive treatment approach. Patients with concurrent diabetes mellitus and coronary heart disease have a worse projection. Under these conditions, the incidence of recurrent myocardial infarction, early disability due to complications, and the risk of coronary death are increased. Therefore, the priority task is to find ways to optimize drug treatment of this category of patients, taking into account the impact of drugs on the pathogenetic links of coronary heart disease progression and the development of cardiovascular complications. One hundred twelve people were examined in the research. The patients had type 2 diabetes with a history of non-Q-myocardial infarction receiving oral antidiabetic therapy and basic therapy, including an ACE inhibitor, a β-blocker, a statin, and an antiplatelet agent. Analysis of the investigated parameters in the leading group after receiving alpha-lipoic acid for 4 months showed a significant decrease in the concentration of C-Reactive Protein, IL-6 and TNF-α. According to the results of our research, taking alpha-lipoic acid for 4 months in patients with type 2 diabetes who underwent non-Q-myocardial infarction reduced the activity of systemic inflammation and did not significantly affect the content of anti-inflammatory IL-10 in patients. In light of the above, it is of interest to administer alpha-lipoic acid to these patients, considering the positive effects of the agent such as antioxidant properties, vasorelaxation, positive metabolic profile, as well as an anti-inflammatory potential.
Environmental Tobacco Smoke and Educational Self-Regulation and Achievement in First Grade High School Students
Authors: Rashidi Mina ,   Student Research Committee, Department of Community Health Nursing, Tabriz University of Medical Sciences, Tabriz, Iran, Mohammadpoorasl Asghar ,   Health and Environment Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Hasan Sahebihagh Mohammad ,   Tabriz Health Services Management Research Center, Department of Community Health Nursing, Tabriz University of Medical Sciences, Tabriz, Iran.,   Mohammad Hasan Sahebihagh, Associate Professor, Tabriz Health Services Management Research Center and Community Health Nursing Department, Tabriz University of Medical Sciences, Tabriz, Iran. E-mail: Sahebihagh@tbzmed.ac.ir
Published: November 2022

Environmental tobacco smoke, containing many toxic gases, suggests inevitable contact of humans with the damaging factors of cigarettes. On average, approximately 40% of children, 35% of women and 32% of men worldwide are exposed to environmental tobacco smoke. This study aims at investigating the relationship between environmental tobacco smoke in adolescents and their educational self-regulation and achievement. In this study, 770 students aged between 13 and 15 were selected and studied using the multistage sampling method. The tools used in this study consisted of four questionnaires, demographic characteristics, environmental tobacco smoke, educational self-regulation, and educational achievement. The validity and reliability of tools have been approved, and the data were analyzed using SPSS v22. The results indicated a significant inverse relationship between environmental tobacco smoke and students’ educational self-regulation and achievement (p-value > 0.001). Given the relationship between exposure to environmental tobacco smoke and educational self-regulation and achievement, it is essential to keep children away from tobacco smoke. Family health and education policy-makers are recommended to design and operate fundamental schemes in order to deal with environmental tobacco smoke.
Developing a Model for National Health Information Governance Program in Iran
Authors: Rouzbahani Fatemeh ,   Department of Health Information Technology and Management, School of Allied Medical Sciences,Shahid Beheshti University of Medical Sciences, Tehran, Iran, Asadi Farkhondeh ,   Department of Health Information Technology and Management, School of Allied Medical Sciences,Shahid Beheshti University of Medical Sciences, Tehran, Iran,   Farkhondeh Asadi,Department of Health Information Technology and Management,School of Allied Medical Sciences,Shahid Beheshti University of Medical Sciences, Tehran, Iran. E-mail: asadifar@sbmu.ac.ir, Rabiei Reza ,   Department of Health Information Technology and Management, School of Allied Medical Sciences,Shahid Beheshti University of Medical Sciences, Tehran, Iran, Moghaddasi Hamid ,   Department of Health Information Technology and Management, School of Allied Medical Sciences,Shahid Beheshti University of Medical Sciences, Tehran, Iran, Emami Hassan ,   Department of Health Information Technology and Management, School of Allied Medical Sciences,Shahid Beheshti University of Medical Sciences, Tehran, Iran
Published: November 2022

With regard to the importance of health Information Governance (IG) programs in improving the quality and reducing the cost of healthcare services and the lack of a coherent health IG program in Iran’s health system, this study aimed to develop a model for national health information governance program in Iran.

The present research was an applied, cross-sectional descriptive study that was done in three steps, including literature review, development of a model for national health IG program in Iran, and model validation. In the third step, we used a questioner to validate the model through the Delphi method. Data analysis was done by descriptive statistics.

The model for the national IG program in Iran was developed in 3 main sections consisting of 13 components, 12 principles, natural and judicial authorities of the health IG program, and their job description. Findings from the validation of the initial model showed that most experts (93%) confirmed the components and sub-components, principles, and natural and legal bodies supervising the national health IG program and their job description in the proposed model.

Considering the structure of the Iranian health system, it was recommended to establish a health IG council in the Ministry of Health and Medical Education in order to develop guidelines and give advice to health care providers. Based on the proposed model, directors and staff of different departments of health care centers, especially those involved in health IG, are also responsible for the better implementation of the national health IG program.
Reasons for Increasing Daily Methadone Maintenance Dosage among Deceptive Patients: A Qualitative Study
Authors: Khosravi Mohsen ,   Department of Psychiatry and Clinical Psychology, Zahedan University of Medical Sciences, Zahedan, Iran,   Mohsen Khosravi, Department of Psychiatry and Clinical Psychology, Baharan Psychiatric Hospital, Zahedan University of Medical Sciences, Postal Code: 9813913777, Zahedan, Iran Phone: +98-5433522636 Fax: +98-5433518352 E-mail: m.khosravi@zaums.ac.ir, Kasaeiyan Rashya ,   Department of Clinical Psychology, Shiraz University of Medical Sciences, Shiraz, Iran
Published: November 2022

Methadone maintenance treatment might be commonly associated with lying for several causes or manipulating psychiatrists and therapists by a number of patients. Deceptive patients tend to manipulate their psychiatrists for multiple causes. This study aims to improve clinicians’ therapeutic decision-making by identifying the reasons for increasing daily methadone maintenance dosage among deceptive patients. One hundred ninety-six patients undergoing the Methadone Maintenance Treatment (MMT) with no statistically significant difference between the overall Addiction Severity Index (ASI) scores at different doses of methadone (< 60 mg/d and ≥ 60 mg/d) and Ahvaz Reality Distortion Inventory (ARDI) scores > 30, were examined in the current qualitative study with multiple semi-structural interviews about the reasons for increasing daily methadone maintenance dosage. The investigation results revealed that the most common reasons for increasing daily methadone maintenance dosage among deceptive patients were opium craving, patient willingness to feel euphoria, fear of the withdrawal signs, earn money through the sale of surplus methadone, improve the symptoms of physical and psychiatric comorbidity, forgetting painful memories, curiosity, the influence of others, sexual issues, feeling of well-being, and appearance changes. Given these reasons, any increase in daily methadone maintenance dosage is not necessarily accompanied by improvement in the clinical condition of patients. However, clinicians can make the most appropriate therapeutic decision by putting the psychological assessments and clinical interviews into play.
Remote Ischemic Conditioning in Acute Ischemic Stroke – A Clinical Trial Design
Authors: Poalelungi Alina ,   Neurology Department, Emergency Clinical Hospital Bucharest, Bucharest, Romania,   Alina Poalelungi, Emergency Clinical Hospita l Bucharest, 8 Calea Floreasca, Bucharest, Romania, University of Medicine and Pharmacy ” Carol Davila” Bucharest, Romania. Phone: 0040721748660. Email: alina.poalelungi@drd.umfcd.ro, Turiac Elena ,   Radiology Department, Emergency Clinical Hospital Bucharest, Bucharest, Romania, Tulba Delia ,   Neurology Department, Colentina Clinical Hospital, Bucharest, Romania, Stoian Diana ,   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Ovidiu Popescu Bogdan ,   Neurology Department, Colentina Clinical Hospital, Bucharest, Romania,   Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   “Victor Babes” National Institute of Pathology, Bucharest, Romania
Published: November 2022

Remote ischemic conditioning represents an intervention based on blood flow reduction applied at a distance from the lesion. The mechanism is supposed to elicit neurovascular protection, anti-inflammatory action, reduced excitotoxicity and metabolic protection. This study aims to explore the efficiency and safety of remote ischemic conditioning during the first five days following in patients who are ineligible for reperfusion treatment (intravenous thrombolysis or/and mechanical thrombectomy). We hypothesized that this intervention would reduce the infarct size (neuroprotection in the reperfusion window) and improve functional recovery. We aim to conduct a double-blind controlled trial, multicenter in two hospitals in Romania. Two hundred patients with acute ischemic stroke randomly divided into an experimental group and a control group will be included. The subjects in the experimental group will be subjected to remote ischemic conditioning twice daily with a maximum of 180 mmHg for 5 days, and a guideline- based treatment as well. The subjects in the control group will receive cuff inflation to 30 mmHg, which will induce sham preconditioning. The primary outcome measure will be radiological - the difference between baseline brain infarct volume and the volume at 180 days in the experimental group versus the control group. The second outcome considers clinical scores such as NIHSS, mRS, IADL, ADL, MOCA, PHQ-9 at baseline, 90 and 180 days; tolerance and side effects of remote ischemic conditioning; the reccurence of stroke or other vascular events at 180 days; incidence of stroke-associated comorbidities and the proportion of death of any cause within 180 days.
Treatment Outcomes of Vaginal Infections on Sexual Function
Authors: Alahverdi Fatemeh ,   Department of Midwifery, Iran University of Medical Sciences, Tehran, Iran, Kheirkhah Masoomeh ,   Nursing Care Research Center (NCRC), Department of Reproductive Health and Midwifery, School of Nursing and Midwifery,Iran University of Medical Sciences, Tehran, Iran,   Masoomeh Kheirkhah School of Nursing & Midwifery, Rashid Yasemi St., Valiasr St., Tehran, 1996713883, Iran; E-mail: Kheirkhah.m@iums.ac.ir; Fax: +(98-21) 88201978, Janani Leila ,   Department of Biostatistics, Iran University of Medical Sciences, Tehran, Iran
Published: November 2022

Vaginal infections are the most common gynecological diseases and one of the causes of sexual dysfunction. In more than 50% of patients, sexual dysfunction is twice as common. Evaluation of the treatment outcome of vaginal infections can be effective in identifying factors related to the sexual function. This is a descriptive-observational study that included patients referred to Imam Sajjad Shahriar Hospital during 2017-2018. Patients that met the inclusion criteria (with vaginal infections of Candida, Gardnerella and mixed infections - Candida and Gardnerella - Mixed group) completed the Female Sexual Function Index (FSFI) questionnaire before and one month after treatment. Data were analyzed by SPSS 16, paired t-test, ANOVA, and multiple regression. P-value <0.05 was considered significant. After the treatment of vaginitis, there was a significant increase in all aspects of the FSFI questionnaire. The mean and standard deviation of sexual function of women before and after treatment were 18.26 ± 4.36 and 26.27 ± 4.97 in the Candida group, 20.06 ± 4.94 and 25.87 ± 5.32 in the Gardnerella group, and 19.69 ± 4.25 and 27.05 ± 5.12 in the Mixed group. Prior to treatment in the Mixed and Gardnerella group, the most important sexual dysfunction was related to the dyspareunia component, while in the Candida group, the most important sexual dysfunction was related to the desire component. After treatment, the components of dyspareunia in the Mixed and Gardnerella group and the orgasmic component in the Candida group showed the greatest improvement. The regression test showed that the effect of age, body mass index and duration of sex on sexual function was significant (P <0.05). Duration of the disease had the greatest impact on sexual dysfunction, and after treatment of the disease, sexual function improved significantly. Proper diagnosis and treatment are effective in improving women’s sexual function. The results of this study can be promoted to midwives and gynecologists.
The Impact of Early Childhood Caries on Oral Health-Related Quality of Life of Children and Caregivers Residing in Rural and Urban Areas of the Rangareddy District
Authors: Nazia Tabassum Syed ,   Department of Pedodontics & Preventive Dentistry, Dr. Shashi’s Dental Studio, Aramghar, Hyderabad, Telangana, India,   Syed Nazia Tabassum, Consultant Pedodontist, Department of Pedodontics & Preventive Dentistry, Dr.shashi’s dental studio, Attapur, Hyderabad, Telangana, India. Phone: 9515407195 E-mail: marvelviks@gmail.com, Reddy Tupalli Abhinaya ,   Department of Pedodontics & Preventive Dentistry, Sri Sai College of Dental Surgery, Vikarabad, Hyderabad, Telangana, India, Reddy Cheruku Sampath ,   Department of Pedodontics & Preventive Dentistry, Sri Sai College of Dental Surgery, Vikarabad, Hyderabad, Telangana, India, Abidullah Mohammed ,   Department of Dental and Biomedical Sciences, Faculty of Dentistry, Al Baha University, Al Baha, Saudi Arabia, Rajajee KTSS ,   Anil Neerukonda Institute Of Dental Sciences, Bheemili, Visakhapatnam, Andhra Pradesh, India, Altaf Hussain Thekiya ,   Department of Orthodontics, SVS Institute of Dental Sciences, Mahabubnagar, Telangana, India
Published: November 2022

Early childhood caries is a condition that impacts oral health-related quality of life of children’s development and well being and also affects parents’ work hours and poses a financial burden on them.

Our objective was to study and compare the impact of early childhood caries on the quality of life of preschool children aged 22–70 months and their caregivers in an urban and rural population using the early childhood oral health impact scale.

The study was conducted on children of the Rangareddy district, Telangana state, aged between 22 –70 months affected by early childhood caries and their parents/guardians. The subjects were given a questionnaire to measure the early childhood oral health impact scale, and the filled questionnaires were analyzed and tabulated.

The mean early childhood oral health impact scale and domain scores for the rural population were significantly higher than that of the urban population signifying a more mediocre quality of life. There was a weak positive and insignificant relationship between early childhood caries and the early childhood oral health impact scale in the rural population, whereas there was a moderately strong, significant positive relationship between the two in the urban population.

Oral health-related quality of life of young children enables parents and caregivers to implement positive dental care practices.
Incides of C-Reactive Protein, Tumor Necrosis Factor-α, Adiponectin, Leptin and Resistin in the Blood of Patients Suffering from Chronic Pancreatitis and Type 2 Diabetes Mellitus
Authors: Hontsariuk Dmytro Olecsandrovich ,   Department of Internal Medicine and Infectious diseases, Bukovinian State Medical University, Chernivtsi, Ukraine,   Dmytro Olecsandrovich Hontsariuk, Department of Internal Medicine and Infectious Diseases, Bukovinian State Medical University,6 Suvorova, ap.7, 58029, Chernovtsy, Ukraine.Phone: +380682910825 E-mail: difess@gmail.com, Ferfetska Kateryna Victorivna ,   Department of Internal Medicine and Infectious diseases, Bukovinian State Medical University, Chernivtsi, Ukraine, Khrystych Tamara Mikolaivna ,   Department of Physical Rehabilitation and Medical and Biological Basis of Physical Education, Kamianets-Podilskyi Ivan Ohiienko National University, Kamianets-Podilskyi, Ukraine, Fediv Olexander Ivanovich ,   Department of Internal Medicine and Infectious diseases, Bukovinian State Medical University, Chernivtsi, Ukraine, Temerivska Tetjana Georgiivna ,   Department of Physical Rehabilitation, Ergotherapy and Home Care, Yuriy Fedkovych Chernivtsi National University, Chernivtsi, Ukraine, Jiguleva Evelina Olexandriivna ,   Department of Physical Rehabilitation and Medical and Biological Basis of Physical Education, Kamianets-Podilskyi Ivan Ohiienko National University, Kamianets-Podilskyi, Ukraine, Honcharuk Ludmila Mikchaliivna ,   Department of Internal Medicine and Infectious diseases, Bukovinian State Medical University, Chernivtsi, Ukraine, Olinik Oksana Yuriivna ,   Department of Internal Medicine and Infectious diseases, Bukovinian State Medical University, Chernivtsi, Ukraine
Published: November 2022

Studying the significance of the immune response to damage and adipokine levels is urgent regarding the development of both chronic pancreatitis and type 2 diabetes mellitus. Our objective was to study the indices of tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), adiponectin, leptin, and resistin as links for triggering the mechanisms of development and progression of the low-grade chronic systemic inflammatory response in chronic pancreatitis (CP) patients with type 2 diabetes mellitus (T2DM). The study groups consisted of 87 patients: 47 patients with isolated CP (group I), 40 with CP combined with T2DM (group II), and 41 practically healthy persons. It has been established that in patients with isolated CP, the TNF-α concentration showed a reliable 1.57-fold (p <0.05) increase compared to practically healthy persons (PHP) and a 1.32-fold increase in patients who also had T2DM (p<0.05). CP patients with type 2 diabetes mellitus had the highest CRP indices (5.5-fold, p <0.05. TNF-α and C-reactive protein indices were higher in patients with chronic pancreatitis and T2DM than those with isolated chronic pancreatitis, characterizing the persistence of chronic systemic inflammation in case of the combined clinical course of these diseases.
Stereomicroscopic and Microscopic Study of Dental Structural Aspects Derived from Iatrogenic and Pathological Processes Suffered by a Second Mandibular Premolar - A Case Study
Authors: Suciu Ioana ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Chirila Mihaela ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Mihaela Chirila, Department of Endodontics, Faculty of Dental Medicine,“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania E-mail: mihaela.chirila@umfcd.ro, Ciocardel Mihai ,   Department of Petroleum Geology and Reservoir Engineering, Petroleum-Gas University of Ploiesti, Romania, Bartok Ioana Ruxandra ,   Department of Esthetics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Amza Oana ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Dimitriu Bogdan ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Voiculeanu Monica ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Coricovac Anca Magdalena ,   Discipline of Embryology, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: November 2022

Microscopic studies performed on extracted human teeth after their preparation in advance is helpful in a relatively good reestablishment of the treatment steps that have been applied to these teeth, as well as an evaluation of the quality of such treatments. Therefore, we have used stereo- and optical microscopy, highlighting aspects of external morphology, as well as root canal space of an extracted mandibular second premolar, subjected to prosthetic and endodontic treatment. In order to verify some technical errors that might occur during the endodontic and restorative treatment, we tried to appreciate the quality of the root canal filling and cervical defect and access cavity restoration of an extracted premolar #45.Without having the data from clinical records, we concluded that the method used for root canal filling was the warm lateral condensation technic; we also appreciated the quality of the fusion of the gutta-percha cones used, so the introduction of heated spreaders only in the central part of the bunch of cones makes it possible to clearly detect the boundaries between these cones towards the outside of the filling.
Retraction Notice to "Congenital Double Scoliosis with 2 Bilaterally Alternant Supranumerary Hemivertebrae and 2 Supranumerary Vertebrae Treated by Growth Guiding Device" [J Med Life 12(2) (2019) 192-193]
Authors: Burnei Gheorghe ,   "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.,   Macta Clinic, Constanta, Romania.,   Tinos Clinic, Bucharest, Romania., Tandea Viorel ,   Pediatric Surgery Department, "Grigore Alexandrescu" Clinical Emergency Hospital for Children, Bucharest, Romania., Muntean Iuliu Liviu ,   Pediatric Surgery and Orthopedy Department, Clinical Emergency Hospital for Children, Brasov, Romania., Moga Marius ,   "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.,   Orthopedy and Traumatology Department, "Dr. Carol Davila" Central Military Emergency University Hospital, Bucharest, Romania., Raducan Ionut Daniel ,   "Vasile Goldis" Western University of Arad, Arad, Romania., Burnei Cristian ,   "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.,   Clinical Emergency Hospital, Bucharest, Romania.
Published: November 2022

Article J Med Life 2019; 12(2): 192-193; doi: 10.25122/jml-2019-0057 has been retracted for legal reasons.
Sexual dimorphic parameters of femur: a clinical guide in orthopedics and forensic studies
Authors: Moosa Shajiya Sarwar ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Shaikh Mohammad Habeebur Raheman ,   Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Khwaja Moizuddin ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Ahmed Hasham Shaikh Siraj ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Banu Siddiqui Faiza ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Rehan Hafiz Daimi Syed ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Dadarao Hiware Sanket ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia,   Sanket Dadarao Hiware, 8a, Ar Rakah Ash Shamaliyah 3938, Dammam, 34224, Kingdom of Saudi Arabia. Phone: +966532550650; E-mail: drsankethiware@gmail.com, Elbadawy Ismail Essam ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Begum Yousuf ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
Published: November 2022

Sexual dimorphic studies of various parameters of the femur play an important role in forensic studies. Various femur morphometric parameters help estimate an individual’s age, sex, and stature from unknown skeletal remains. This research was done to analyze maximum length, trochanteric oblique length, and diameter of the femur head for sexual dimorphism. The study was done on 200 (128 male & 72 female) Indian adult human femora, which were fully ossified, dry, and free from deformity. The maximum length of the femur (L), trochanteric oblique length (TOL), and vertical diameter of the head (VDH) were measured using an osteometric board and digital Vernier calipers. The mean length of the femur was 436.88 mm in males and 402.38 mm in females, respectively. The mean trochanteric oblique length of the femur was 423.78 mm in males and 387.18 mm in females, respectively. The mean vertical diameter of the femur head was 43 mm in males and 38.19 mm in females, respectively. Depending upon the results of this study, it was concluded that the mean values of maximum length, trochanteric oblique length, and vertical diameter of the femur head are significantly higher in males than females. These parameters are useful and reliable for sexual dimorphism in anthropometric and forensic studies, especially in identifying skeletal remains. These differences can also be considered in selecting or designing the exact ranges of the gender-specific prosthesis for Orthopedic surgeries.
Development of the Saudi Arabian trauma system
Authors: Chowdhury Sharfuddin ,   Trauma Center, King Saud Medical City, Riyadh, Saudi Arabia,   Sharfuddin Chowdhury, Director of Trauma Center,  King Saud Medical City, Riyadh,  Saudi Arabia. Phone: +966 11 837 1777 (Ext: 75537); E-mail: s.chowdhury@ksmc.med.sa, Mok Dennis ,   Medical Management Consulting, Birkdale, Queensland, Australia, Leenen Luke ,   Department of Trauma, University Medical Center Utrecht, Utrecht, Netherlands
Published: November 2022

A dedicated network-based trauma system ensures optimal care to injured patients. Considering the significant burden of trauma, the Kingdom of Saudi Arabia is striving to develop a nationwide trauma system. This article describes the recent design, development, and implementation of the Saudi Arabian trauma system in line with Vision 2030. The basis of our strategy was the find, organize, clarify, understand, select-plan, do, check, and act (FOCUS-PDCA) model, developed by engaging key stakeholders, including patients. More than 300 healthcare professionals and patients from around the Riyadh region assessed the current system with three solutions and roadmap workshops. Subsequently, the national clinical advisory group (CAG) for trauma was formed to develop the Saudi Arabian trauma system, and CAG members analyzed and collated internationally recognized trauma systems and guidelines. The guidelines’ applicability in the kingdom was discussed and reviewed, and an interactive document was developed to support socialization and implementation. The CAG team members agreed on the guiding principles for the trauma pathway, identified the challenges, and finalized the new system design. They also developed a trauma care standard document to support and guide the rollout of new trauma networks across the kingdom. The CAG members and other stakeholders are at the forefront of implementing the trauma system across the Riyadh region. Recent trauma system development in Saudi Arabia is the first step in improving national trauma care and may guide development in other locations, regionally and internationally, to improve outcomes.
New approach for hepatocellular carcinoma treatment
Authors: Tabacelia Daniela ,   Department of Gastroenterology, Sfanta Maria Clinical Hospital, Bucharest, Romania,   Tabacelia Daniela, Department of Gastroenterology, Sfanta Maria Clinical Hospital, Bucharest, Romania. E-mail: daniela.tabacelia@gmail.com, Stroescu Cezar ,   Department of Surgery, Sfanta Maria Clinical Hospital, Bucharest, Romania,   Department of Surgery, Fundeni Clinical Institute, Bucharest, Romania,   Stroescu Cezar, Department of Surgery, Sfanta Maria Clinical Hospital, Bucharest, Romania. E-mail: cezar.stroescu@gmail.com, Dumitru Radu ,   Radiology Department, Sfanta Maria Clinical Hospital, Bucharest, Romania,   Radiology Department, Fundeni Clinical Institute, Bucharest, Romania, Grigorescu Raluca Roxana ,   Department of Gastroenterology, Sfanta Maria Clinical Hospital, Bucharest, Romania, Martiniuc Alexandru ,   Department of Surgery, Sfanta Maria Clinical Hospital, Bucharest, Romania, Husar-Sburlan Ioana Alexandra ,   Department of Gastroenterology, Sfanta Maria Clinical Hospital, Bucharest, Romania, Copca Narcis ,   Department of Surgery, Sfanta Maria Clinical Hospital, Bucharest, Romania
Published: November 2022

Hepatocellular carcinoma (HCC) is the fifth most common cancer, with an increasing incidence in recent years. The prognosis is unfavorable, representing the third most frequent cause of cancer-related death worldwide. This is because it generally develops in patients with pre-existing liver pathology, thus limiting therapeutic options. The role of ablative therapies is well-established in nodules smaller than 3 cm, but for nodules from 3 to 5 cm, the best therapeutic management is not well defined. Recent studies reported that combining minimally invasive procedures like transarterial chemoembolization (TACE) with microwave ablation (MWA) or radiofrequency ablation is superior to each alone. However, there is no consensus regarding the timing and the order in which each procedure should be performed. We report a case of an 86 years old male with HCV-related compensated hepatic cirrhosis and multiple cardiac comorbidities diagnosed with a 47/50 mm HCC. Pre-surgical evaluation of the associated pathologies determined that the risk for the surgical approach outweighs the benefits, so the committee decided to treat it in a less invasive manner. We performed MWA and TACE in a single session with technical success according to the modified Response Evaluation Criteria in Solid Tumors (m-RECIST). This case illustrates the first case of simultaneous MWA and TACE performed in our center. This new approach of hepatocellular carcinoma appears to be a good alternative to more invasive methods, with good results even in older people that are unfit for surgery.
Connexin 26 (GJB2) gene mutations linked with autosomal recessive non-syndromic sensor neural hearing loss in the Iraqi population
Authors: Al-janabi Anwar Madlool ,   Department of Clinical Chemistry, College of Medicine, University of Kufa, Najaf, Iraq,   Anwar Madlool Al-janabi, Department of Clinical Chemistry, College of Medicine, University of Kufa, Najaf, Iraq. E-mail: anwar.aljanabi@uokufa.edu.iq, Ahmmed Habeeb Shuhaib ,   Department of Otolaryngology, College of Medicine, University of Kufa, Najaf, Iraq, Al-Khafaji Salih Mahdi ,   Department of Anatomy & Histology, College of Medicine, University of Kufa, Najaf, Iraq
Published: November 2022

Deafness is a total or partial hearing loss that may appear at any age and with different degrees of severity. Approximately 50% of hearing loss have a genetic origin, and among them, non-syndromic sensorineural deafness represents about 70% of the cases. From them, 80% correspond to autosomal recessive inheritance deafness. Autosomal recessive deafness was not studied enough at the molecular level in Iraq. This study aimed to verify the frequency of three GJB2 mutations in non-syndromic sensorineural deafness in the Iraqi population. The current case-control study was conducted from January 2018 to January 2020. The study included 95 deafness patients (55 males and 40 females) and 110 healthy control group. Age and sex were matched between the two groups. In order to detect c.35delG, 235delC, and 167delT mutations in the GJB2 gene, we employed the PCR-RFLP technique. The c.35delG was the main frequent mutation encountered with the GJB2 gene among patients with autosomal recessive non-syndromic sensorineural hearing loss. Among them, 35 (36.8%) were homozygous, 40 (42.1%) were heterozygous, and 20 (21.1%) were wild genotypes. The second-degree mutation in the GJB2 gene was c.235delC mutation, which from the 95 deaf patients, there were 20 (21.1%) with homozygous, 33 (34.7%) heterozygous, and 42 (44.2%) wild genotypes. None of the 95 deaf patients showed the c.167delT mutation, and no mutations appeared in the control group. Our data concluded that the GJB2 c.35delG and c.235delC gene mutations were the main cause of autosomal recessive non-syndromic sensorineural hearing loss in the Iraqi deaf population.
Prevalence and seasonal pattern of enteric viruses among hospitalized children with acute gastroenteritis in Samawah, Iraq
Authors: Thwiny Hazim Talib ,   College of Veterinary Medicine, University of Basrah, Basrah, Iraq, Alsalih Nawar Jasim ,   Division of Microbiology, College of Veterinary Medicine, Al-Muthanna University, Samawah, Iraq, Saeed Zeayd Fadhil ,   Nursing Department, Al Furat Al Awsat Technical University, Samawah, Iraq, Al-Yasari Ali Mosa Rashid ,   Division of Physiology, College of Veterinary Medicine, Al-Muthanna University, Samawah, Iraq, Al-Saadawe Moyed Abd AlHussein ,   Central South University, Changsha, China, Alsaadawi Mohenned Abd ElHussein ,   Department of Parasitology, College of Veterinary Medicine, Al-Muthanna University, Samawah, Iraq,   Mohenned Abd ElHussein Alsaadawi, Department of Parasitology, College of Veterinary Medicine, Al-Muthanna University, Samawah, Iraq. E-mail: mohenned.hemza@mu.edu.iq
Published: November 2022

Almost all of the deaths happening under the age of 5 occur in the developed countries of Africa and Asia. This study included children admitted to the surgical care, aged 6 months to 5 years, who suffered from acute gastroenteritis and received treatment at Samawah, Iraq, from December 2018 to December 2019. Test results detected different types of rotaviruses, adenoviruses, astroviruses using ELISA. 56.6% of the infections were attributed to a viral pathogen. The main cause was attributed to rotavirus and adenovirus. The causative agents of diarrheal diseases in 28.1% of cases are rotaviruses, in 17.05% – adenoviruses, in 11.43% – astroviruses. Viral mono-infections are detected more often than mixed infections. Viral intestinal infections are characterized by seasonality and rise in the cold season, with a peak incidence of rotavirus infection in April, adenovirus infection in November, and astrovirus infection in December.
Diabetes, pregnancy and spina bifida
Authors: Georgescu Tiberiu ,   National Institute of Mother and Child Care Alessandrescu-Rusescu, Bucharest, Romania,   Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Ionescu Olivia ,   Department of Obstetrics and Gynecology, South Nurnberg Hospital, Nurnberg, Germany, Ionescu Paris ,   Department of Obstetrics and Gynecology, Ovidius University, Constanta, Romania, Bacalbasa Nicolae ,   Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Pop Lucian Gheorge ,   National Institute of Mother and Child Care Alessandrescu-Rusescu, Bucharest, Romania,   Lucian Gheorghe Pop, National Institute of Mother and Child Care Alessandrescu-Rusescu, Bucharest, Romania. Phone: 0040741044720; E-mail: popluciangh@icloud.com
Published: November 2022

Spina bifida is a disorder characterized by failure of the neural tube to form during embryological development. The early signs in the head and spine may be detected on ultrasound from 11 weeks of gestation. Diabetes is a well-known teratogen factor that increases the chances of birth defects, such as neural tube defects. We report a 12 weeks case of spina bifida in type 1 diabetes.