bluuebunny/crossref_metadata_2025 huggingface dataset:
النقود الإسلامية الإلكترونية المؤشرة
Authors: Ameen Owaisi
Published: December 2019

تهدف هذه الورقة البحثية إلى اقتراح منتج نقدي مالي إسلامي جديد، جاء تحت مسمى “النقود الإسلامية الإلكترونية المؤشرة”، وهو ابتكار لنوع خاص من النقود المشفرة التي تساعد على قيام التجارة الإلكترونية في العالم العربي والإسلامي، وكذلك تفي بتسوية الديون والالتزامات العاجلة والآجلة إلكترونياً. وأهم نتيجة توصل إليها الباحث في هذه الورقة البحثية، هي ضرورة إيجاد حلول إسلامية لمشكلة المعاملات الإلكترونية من الناحية النقدية؛ وذلك يعني إيجاد وسيلة دفع إلكترونية توافق الشريعة الإسلامية، وتمنع الوقوع في المحرمات، وخاصة الربا الناتج عن تدني القيمة. إذن “النقود الإسلامية الإلكترونية المؤشرة” هي حل مقترح لجملة الدول العربية والإسلامية؛ لإقامة تجارة إلكترونية عصرية متطورة وموافقة للشريعة الإسلامية، كما أنها الحل؛ لتسوية المدفوعات بين الدول بوحدة نقدية ثابتة القيمة وموحدة.
دور المؤسسات التطبيقية في الاقتصاد الإسلامي في تمويل عجز الموازنة بالجزائر
Authors: Da'aas Zuhair
Published: December 2019

ظلت ميزانية الدولة في الجزائر طيلة الفترة الممتدة من 2000 – 2016 رهينة لتقلبات أسعار النفط رغم السياسة الحذرة التي انتهجتها الحكومة عند إعدادها للميزانية، حيث تم تحديد سعر مرجعي في حدود 37 دولاراً للبرميل تبنى على أساسه الموارد النفطية المخصصة لتمويل الميزانية و الفائض يصب في صندوق ضبط الموارد، ما جعل العجز الموازني الذي تسجله الجزائر منذ سنة 2000 حسابياً فقط، بحكم العودة في كل مرة إلى أرصدة صندوق ضبط الموارد لتمويله، إلا أن ناقوس الخطر قد تم دقه جدياً بعد تهاوي أسعار النفط منذ النصف الثاني من سنة 2014، حيث تقلصت مداخيل الدولة بالعملة الصعبة بأكثر من 50% ، في حين استمرت سياسة الإنفاق بوتيرة عالية، وهو ما يحتم على الحكومة البحث عن أدوات بديلة غير تقليدية تتمتع بالكفاءة العالية في تخصيص الموارد، تطرح الدراسة منها المؤسسات التطبيقية في الاقتصاد الإسلامي وبخاصة مؤسسة الزكاة ومؤسسات القطاع الوقفي كآلية مهمة لتمويل العجز الموازني في ظل سيناريوهات مستمرة طيلة السنوات القادمة. الكلمات المفتاحية: العجز الموازني؛ الوقف واقتصاد الزكاة؛ المؤسسات التطبيقية للمالية الإسلامية.
PCR Detection of Scopulariopsis brevicaulis
Authors: KORDALEWSKA MILENA , BRILLOWSKA-DĄBROWSKA ANNA
Published: December 2019

Scopulariopsis brevicaulis is known as the most common etiological factor of the mould toenail infections. There are also reports indicating that S. brevicaulis could cause organ and disseminated infections. Nowadays microscopic observations from the direct sample and culture are crucial for the appropriate recognition of the infection. In this paper a PCR-based method for S. brevicaulis detection is presented. The specificity of the reaction was confirmed, as positive results were obtained only for tested S. brevicaulis isolates and no positive results were obtained for other moulds, dermatophytes, yeast-like fungi, and human DNA.
Escherichia coli and Salmonella spp. early diagnosis and seasonal monitoring in the sewage treatment process by EMA-qPCR method
Authors: KACPRZAK MAŁGORZATA , FIJAŁKOWSKI KRZYSZTOF , GROBELAK ANNA , ROSIKOŃ KAROLINA , RORAT AGNIESZKA
Published: December 2019

Numerous studies have recently shown that molecular biology tools can allow for early diagnosis of pathogens and can substitute existing cost and time-taking traditional methods. One of them, the qPCR, is successfully used in microbiology and its utility has been assessed for many different biological materials. The aim of this study was to: 1) determine, optimize and apply qPCR as a method to detect Escherichia coli and Salmonella spp. in primary influents and final effluents from municipal wastewater treatment plant 2) define if addition of ethidium bromide monoazide (EMA) before DNA extraction can allow to distinguish between alive and dead bacteria, 3) quantify E. coli and Salmonella spp. in wastewater during four seasons by qPCR and traditional spread plate method and determine the correlation between the indicator and pathogenic microorganisms. The obtained results has shown that qPCR can be used as a quantitative method in the diagnosis of investigated bacteria in wastewater with EMA pretreatment as a crucial step for a proper quantitative analysis of the presence of these bacteria in wastewater. Both E. coli and Salmonella spp. bacteria species were present in all samples of primary influents and final effluents. Our study shown that the quantity of investigated bacteria is strictly correlated with the season that they were obtained in.
Biodiversity of dominant cultivable endophytic bacteria inhabiting tissues of six different cultivars of maize (Zea mays L. ssp. mays) cropped under field conditions
Authors: PISARSKA KATARZYNA , PIETR STANISŁAW JERZY
Published: December 2019

Endophytic bacteria (EnB) play a crucial role in plant development. This study was an attempt to isolate and identify dominant cultivable EnB inhabiting young seedlings germinated in vitro and leaves of six maize cultivars grown under field conditions at temperate climate zone with culture-dependent approach. We isolated bacteria from field cropped maize only. Strains were identified based on 16S rRNA gene sequencing. In particular, members of Actinobacteria, Bacteroidetes, Firmicutes and α- and γ-Proteobacteria were found. Species of two genus Pseudomonas and Bacillus were dominant among them. Higher diversity of EnB was found in plants collected from Kobierzyce, where we identified 35 species from 16 genera with 22 species uniquely found at this field. On the contrary, from maize leaves collected at Smolice we identified 24 species representing 10 genera with 10 species uniquely isolated from this field. However, none of species was common for all cultivars at both locations. Among isolated EnB six species only, Pseudomonas clemancea, Pseudomonasfluorescens, Bacillus megaterium, Bacillus simplex, Arthrobacter nicotinovorans and Arthrobacter nitroguajacolicus, were found in aboveground parts of the same cultivar grown on both tested fields. The fact that the same cultivars, sown from the same lots of seeds, under field conditions on two different locations were colonized with noticeably different associations of cultivable EnB suggest that cultivar genotype is an important factor selecting endophytic bacteria from local agro-environment. To our knowledge this is first report about the significant variation of diversity of cultivable endophytic bacteria inhabiting aboveground parts of the same maize cultivars grown at different locations.
Characterisation of Yersinia secretion apparatus-pathogenicity island (Ysa-PI) of Yersinia enterocolitica 1B/O8 in Poland: an idle Ysa is a specific hallmark of the epidemic sensu stricto strain
Authors: WOŁKOWICZ TOMASZ , ZACHARCZUK KATARZYNA , ROKOSZ-CHUDZIAK NATALIA , RASTAWICKI WALDEMAR , GIERCZYŃSKI RAFAŁ
Published: December 2019

Yersinia secretion apparatus (Ysa), the chromosomal type three secretion system (T3SS) is considered to contribute to virulence of high-pathogenicity Yersina enterocolitica biovar 1B. DNA-sequence of Ysa pathogenicity island was determined for clinical isolate DM0110 of Y enterocolitica 1B/08 with origin in Poland. We found a premature stop-codon in the regulatory gene ysrR (mutation at position 269). Altered ysrR was detected in all tested 78 isolates of Y enterocolitica 1B/O8 collected from clinical samples in Poland from 2004 to 2013. Since aberrations in YsrR are considered to inactivate Ysa, our findings may suggest Ysa is not indispensable for Y enterocolitica 1B/O8 to infect humans.
ESTIMASI POTENSI BIOGAS DARI PALM OIL MILL EFFLUENT (POME) PABRIK KELAPA SAWIT DI PROVINSI JAMBI
Authors: S Guntar Marolop , Hadrah Hadrah
Published: December 2019

The increasing of palm oil mills as a result of an increase in public interest of land exploitation to produce  palm oil can cause high environmental pollution if the waste oil generated were not managed properly. Palm Oil Mill Effluent (POME) is the wastewater generated by palm oil extraction process. On the other hand, POME is a renewable energy source. To address the need for electrical energy increases, the monitoring of POME is an effort that needs to be studied because POME is no longer a pollutant to the environment but a helpful resource.This study uses field data collection in the form of POME volume and treatment plant process management to determine the COD levels so that the estimation of total biogas can be done. Based on the calculation of the energy potential of POME in Jambi province with  processing capacity of the entire Province amounted to 1,230 tons FFB / hour, 20 hours operating time / day and COD content of 50,000 mg / L, the amount of energy can be obtained is 737.712 MWh / day or 269.26 GWh / Year.Keywords: POME, biogas, energy
Analisis Penurunan Eceng Gondok (Eichornia Crassipes) dalam Perbaikan Kualitas Air Ditinjau Dari Parameter Timbal (Pb) dan Besi (Fe)
Authors: Marhadi Marhadi , Wibowo Henri , Kurniawan Vivie Amelia
Published: December 2019

Danau Sipin memiliki potensi perairan umum yang cukup besar dengan luas 40 Ha mengalami degradasi fungsi lingkungan ditandai dengan fluktuasi debit air antara musim kemarau dan musim hujan pendangkalan alur sungai dan semakin berkurangnya kapasitas penampungan air danau, Tujuan Penelitianmengetahui berapa perbandingan penurunan parameter Pb dan Fe oleh eceng gondok dari setiap bak, perubahan Ph dan Suhu dari setiap bak dan perubahan fisik eceng gondok sebelum dan sesudah penellitian. Metode penelitian mengetahui penurunan kadar timbal (Pb) dan besi (Fe) terhadap eceng gondok. Pada penelitian ini dibagi 4 perlakuan dengan berat eceng gondok yang berbeda namun kapasitas air sama yaitu sebesar 12 liter di setiap bak, dengan perlakuan sebagai berikut, pemberian eceng gondok atau disebut dengan bak kontrol (K) perlakuan pertama pemberikan eceng gondok sebesar 200, perlakuan kedua pemberian eceng gondok sebesar 400 gr dan perlakuan ketiga pemberian eceng gondok sebesar 600 gr,.masing-masing dari perlakuan tersebut mengalami pengontrolan yang sama, yaitu mengecek perubahan kadar pH dan suhu serta waktu detensi awal eceng gondok kontak dengan air sampel selama 9 hari. Setelah 9 hari dilakukan pengambilan sampel ke 2, pada hari ke 11 dilakukan pengambilan sampel ke 3, dan pada hari ke 13 dilakukan pengambilan sampel terakhir. Hasil penelitian untuk parameter besi (Fe) pengujian pada bak 200 gr sebesar rata-rata - 0.01 mg/L - 0.023 mg/L, bak 400 gr rata-rata sebesar 0.01 mg/L, bak 600 gr sebesar rata-rata 0.01 mg/L - 0.032 mg/L untuk pengujianparameter timbal (Pb) pada bak 200 gr sebesar 0.02 mg/L, bak 400 gr sebesar 0.02 mg/L, bak 600 gr sebesar 0.02 mg/L, untuk pengukuran pH dan suhu mencapai 29? dengan pH bak 200 gr 5, pH bak 400 gr 6, pH bak 600 gr 6,5 dan pH bak K 6. Perubahan fisik eceng gondok sebelum dan sesudah eksperimen sangat terlihat jelas pada daun dan batangnya, sebelum penelitian eceng gondok pada setiap bak berwarna hijau dan batang yang segar dan setelah penelitian ada beberapa eceng gondok yang berubah warna kekuningan dan layu dan perubahan pada airnya. Eceng gondok 600gr dengan kapasitas air 12 liter, selain daun eceng gondoknya yang menguning dan batangnya yang layu, dan air berubah semakin keruh dikarenakan kapasitas air 12 liter tidak cukup menampung eceng gondok dengan berat 600 gr.
Evaluasi Kebutuhan Air Minum Untuk Kota Banda Aceh dalam Mencapai Akses Universal Tahun 2019
Authors: Darnas Yeggi
Published: December 2019

Kebutuhan air bersih meningkat sejalan dengan laju pertumbuhan penduduk, pertumbuhan kegiatan ekonomi dan tingkat kesadaran masyarakat akan pentingnya air minum untuk hidup sehat. Dilain pihak kapasitas sarana dan prasarana sistem penyediaan air minum belum mampu memenuhi kebutuhan air minum masyarakat, sehingga diperlukan peningkatan kapasitas produksi dan sistem jaringan pipa distribusi air minum. Kesinambungan pelayanan air minum yang memadai baik secara kuantitas, kualitas serta kontinuitas adalah hal pokok untuk meningkatkan derajat kesehatan masyarakat dan menunjang kegiatan perekonomian/industri. Tingkat pelayanan PDAM Kota Banda Aceh saat ini sudah mencapai 94,26%, dengan target tingkat pelayanan 100% di tahun 2035. Namun Perpres Nomor 2 Tahun 2015 tentang Rencana Pembangunan Jangka Menengah Nasional (RPJMN) mengamanatkan pencapaian akses air minum layak dan sanitasi layak 100 % bagi seluruh masyarakat pada tahun 2019. Agar tingkat pelayanan air minum PDAM Kota Banda Aceh dapat mencapai 100%, maka harus ada usaha yang dilakukan selain meningkatkan kapasitas produksi - yang tidak dapat dilakukan dalam waktu singkat. Pada penelitian ini, dilakukan studi evaluasi sistem distribusi dalam pemenuhan kebutuhan air minum. Distribusi air minum Kota Banda Aceh dibagi menjadi empat zona. Pendistribusian air minum oleh PDAM Kota Banda Aceh dilakukan berdasarkan jalur pipa distribusi utama yang sudah dibangun. Penelitian difokuskan pada zona 3 dan zona 4 yang merupakan zona dengan cakupan pelayanan dua terbesar. Selain itu pada kedua daerah pelayanan tersebut sering terjadi komplain oleh pelanggan terkait dengan seringnya tidak sampai aliran air ke rumah mereka. Hasil evaluasi dan simulasi menggunakan software EPANET menunjukkan bahwa agar tercapainya akses air minum layak 100% pada tahun 2019, diperlukan penggantian pipa distribusi dari diameter 100mm menjadi diameter 200mm di tiga tempat pada zona 3 (sepanjang 5831,63m) dan satu tempat di zona 4 (sepanjang 3293,81m).
Efektifitas Bank Sampah dalam Pengelolaan Sampah di Kota Jambi
Authors: Tampubolon David Evianto , Marhadi Marhadi , Riyanti Anggrika
Published: December 2019

Penelitian ini dilaksanakan di tiga Bank Sampah di Kota Jambi yang terdapat sistem 3R yaitu Reduce, Reuse, Recycle. Pengumpulan data ini didapat dari hasil survey, kuesioner, wawancara lalu di bandingkan dari 3 Bank Sampah 3R tersebut dan di dapat hasil efektifitas Bank Sampah berbasis 3R yang berada di Kota Jambi. Hasil penelitian yang penulis dapatkan adalah merupakan suatu gambaran pengetahuan yang baik, sikap yang cukup baik dan perilaku yang kurang dari masyarakat Kota Jambi terhadap sampah. Dari penelitian yang dilakukan oleh penulis, maka dapat diambil kesimpulan bahwa masyarakat Kota Jambi memiliki pengetahuan yang baik tentang sampah, sikap yang cukup baik terhadap sampah, tetapi perilaku yang kurang baik terhadap sampah dikarenakan kurang perhatian dari pemerintah.
Entrepreneurial Intentions among Engineering Students: Applying a Theory of Planned Behavior Perspective
Authors: Valencia-Arias Alejandro , Montoya Restrepo Luz Alexandra
Published: December 2019

This research employs the Theory of Planned Behavior in an attempt to identify the factors that exert an influence on the entrepreneurial intentions of undergraduate students. The authors hope to contribute to understanding the process of entrepreneurial intentions in engineering students in the context of a developing country, taking as an example engineering students in the city of Medellín. Descriptive field and cross-sectional research was conducted using a quantitative methodological design. Data was collected using a self-administered questionnaire. The sample was made up of 636 undergraduate engineering students. Following validation, statistical Somers’ D was used to evaluate the associations between the constructs found in the Theory of Planned Behavior. It proved possible to corroborate the influence of attitudes, perceived behavioral control, current behavioral control and entrepreneurial behavior on the intention of engineering students to create a business in the future. The authors propose that current behavioral control is the most influential factor on entrepreneurial intention in engineering students. Consequently, university entrepreneurial education initiatives and efforts to motivate entrepreneurship need to be accompanied by programs that help students identify business opportunities and financial mechanisms that will allow fledgling entrepreneurs to feel confident in their personal capacities (attitudes) and their ability to access financial support to help them create businesses.
EXAMINATION OF STUDENTS’ ENGAGEMENT WITH R-SPQ-2F OF LEARNING APPROACH IN FLIPPED SUSTAINABLE SCIENCE COURSE
Authors: Jeong Jin Su , González-Gómez David , Conde-Núñez M. Carmen , Gallego-Picó Alejandrina
Published: December 2019

The students’ engagement was deemed significant to research due to the changing study structures from course-based to student-centered and competence-based in sustainable science higher education. Still, its change and coping strategies is considered as somewhat unfamiliar learning environment. Research examined students’ engagement to the learning approach of a flipped-classroom model for sustainable science course with the Revised Two-Factor Study Process Questionnaire (R-SPQ-2F). It assesses research proposals, which students are utilizing to learning, and engagement and individual abilities as well. The research was conducted with the students enrolled in the “Atmospheric Pollution” course of the Environmental Science undergraduate program (n=64). The results obtained through the R-SPQ-2F showed the students’ number reaching higher “deep approach” in their learning increased at the course end, while it can be observed that the students’ number marking “surface approach” below the mean value was slightly lower (pre- and post-test comparison). It can be concluded that students are employing more engagement in their works and enhancing their personal skills as well with the teaching methodology. Results obviously specified that the study structure change was a phase into correct emphasis to improve students’ engagement in the flipped sustainable science education.
Keywords: engagement, science learning, R-SPQ-2F, flipped-classroom, sustainable education, study approach.
STUDENTS’AND TEACHERS’ PERCEPTION OF SCIENTIFIC MODELS: TRANSITION FROM DAILY TO SCIENTIFIC LANGUAGE
Authors: Lee Show-Run , Lu Yu-Ling , Lien Chi-Jui
Published: December 2019

The use of scientific models has been regarded as an important skill for scientific enquiry. However, although many national curricula and major international science education reform movements have stressed the use of scientific models in science teaching and learning, students and teachers generally do not know how to perceive models properly. This research explores these perceptions about scientific models using the Perception of Models in Science (PMS), a self-developed instrument designed to collect participants’ model perceptions, among 218 grade 4, 6 and 8 students, as including 57 of the science teachers in their respective schools, and treated these statistically with analysis of variance, post hoc analysis and cluster analysis. Results showed that the groups of students and teachers agreed that the most acceptable model representation is reality but remained uncertain on whether a model can be presented through nonreality representations (i.e., diagram, graph, symbol, writing and speech). Participants did not significantly differ in perception intensity of seeing each model representation and held three kinds of model perceptions: daily language, transitional and scientific language. This research thus proposes action plans in managing this transitional perspective in learning the concepts of scientific models. Keywords: model representations, scientific model, students’ view, teachers’ view
An Empirical Study for the Financial Situation of Youth CSOs in TRB1 Region of Turkey
Authors: AYHAN Emrah
Published: December 2019

This study evaluates factors which influence financial capacity of Civil
Society Organizations (CSOs) operating in TRB1 Region (Malatya, Elazığ, Bingöl
and Tunceli) of Turkey. Because, although the need for CSO activity is higher
in less developed regions, the presence of CSOs is more limited in these
regions compared to more developed regions. On the other hand, CSOs with higher
financial capacity can provide more qualified, effective and sustainable public
goods and services in the areas and regions where public institutions and
private sector organizations fail. In this sense, existing assumptions about
the factors influencing financial capacity of CSOs are noted after reviewing theoretical
and empirical studies in the literature. In order to test these assumptions by
the sample of CSOs in TRB1 Region of Turkey, primary and secondary sources of
data were used. Primary data was collected from a semi-structured and detailed
survey research that was applied to organizational leaders (e.g., manager, director
and youth representative) of 66 Youth CSOs that operate in the areas of youth,
education and sport in TRB1 Region. In addition, secondary data was collected
from the database of Directorate General of Relations with Civil Society under
T.R. Ministry of Interior. Collected data was evaluated by descriptive
statistical method to analyze relationships between dependent and independent
variables. The research findings show that factors such as cooperation with
external stakeholders, managerial competence and revenue sources have
significant influence on the financial capacity of CSOs.
PENGARUH PERBEDAAN BUDAYA DAN POLITIK TERHADAP DINAMIKA PERSAINGAN KEKUATAN EKONOMI AUSTRALIA DAN CHINA DI KAWASAN ASIA PASIFIK
Authors: Saradewa Zet , Sunarti Sunarti , Maulana Ireng
Published: December 2019

Australia dan China adalah dua negara di Asia Pasifik yang pertumbuhan ekonominya cukup tinggi di dunia, dengan atmosfer ekonomi kapitalis yang sangat berpengaruh terhadap siklus perekonomian di kawasan Asia Pasifik. Perbedaan nilai-nilai budaya dan sosial antara dua negara ini memberikan corak yang berbeda dalam kekuatan ekonomi masing-masing negara, yaitu Australia yang barat dan China yang timur. Perbedaan tersebut ditambah dengan kekuatan dua ideologi yang berbeda yang ada di belakang keduanya, yaitu Australia yang liberal dan China yang komunis. Tulisan ini ingin menjawab bagaimana perbandingan kekuatan antara Australia dan China yang berbeda budaya dan sosial dalam bidang ekonomi di Asia Pasifik. Dalam tulisan ini, penulis menggunakan teori rivalitas dalam interdepensi. Tulisan ini menggunakan metode deskriptif dengan pendekatan kualitatif. Data yang digunakan dalam penelitian ini adalah data yang terdiri dari buku, jurnal, dan data dari situs website tepercaya yang mendukung penjelasan akhir dari artikel ini. Hasil dari tulisan ini menunjukkan bahwa pertumbuhan ekonomi Australia ditopang oleh layanan keuangan dan asuransi, yang merupakan imbas dari kesadaran masyarakat yang cukup tinggi yang terdapat di negara maju. Sedangkan pertumbuhan ekonomi China ditopang oleh investasi infrastruktur, yang merupakan bagian dari proses industrialisasi di negara berkembang. Dalam rangka menggerakkan kawasan Asia Pasifik dalam bidang ekonomi, China dan Australia melakukan kerja sama dengan negara-negara Asia Pasifik dengan masuk dalam keangotaan Asia-Pacific Economic Community (APEC) dan Regional Comprehensive Economic Partnership (RCEP).
JAPAN AS AN ECONOMIC MODEL: IS IT STILL RELEVANT?
Authors: Nangoi Ronald
Published: December 2019

Japanâ€™s dominant position in world economy has currently been replaced by China. Yet, Indonesia which has close relationship with Japan could still learn from this country in its economic and business development.  The study perceived from both macro-economic and micro-business perspectives is to affirm that itâ€™s still relevant for Japan to be an economic model due to its  past contribution to the rise of Asian and world economy and its long experience in manufacturing and management, its reliance on quality and productivity, and its business ethics as well. 

Key words: Asian and world economy, competitive manufacturing, management system, cultural values, JIEPA 

 Abstrak

Dewasa ini posisi dominan Jepang pada ekonomi dunia telah digeser oleh Tiongkok.  Namun, Indonesia yang memiliki hubungan erat dengan Jepang sebenarnya masih bisa belajar dari negara dalam pembangunan ekonomi dan bisnis.  Studi yang ditinjau dari sudut pandang makro-ekonomi dan mikro-bisnis dimaksudkan untuk mempertegas bahwa masih relevan bagi Jepang untuk menjadi model ekonomi sehubungan dengan sumbangsih Jepang di masa lalu bagi bangkitnya ekonomi Asia dan dunia serta pengalaman Jepang dalam manufakturing dan manajemen, pengandalan Jepang atas mutu dan produktivitas, dan juga etika bisnis.

Kata kunci: ekonomi Asia dan dunia, manufakturing yang berdaya saing, sistem manajemen, nilai-nilai budaya, JIEPA
Free hemoglobin and sepsis
Authors: Orlov Yu. P. , Govorova N. V. , Khramykh T. P. , Glushchenko A. V. , Nochnaya Yu. А.
Published: December 2019

Purpose of Research:to determine whether we can use free hemoglobin concentration as early prognostic marker and a predictor of mortality in sepsis.

Materials and Methods.In a retrospective study in 60 patients aged 47.6 ± 7.2 years with sepsis (30.4 ± 2.1 points on the Mannheim’s scale for evaluation of the severity of peritonitis) modern methods of statistics (ROC-analysis) hypothesis was tested, whether level of free hemoglobin in the first 24 hours from the moment of admission can be used as a biomarker for diagnosis and prognosis for severe sepsis. Informative criterion was compared with the information of the procalcitonin test.

Results.The present study had shown that the above average free hemoglobin concentration, measured on the first day of the heavy flow of sepsis, is directly connected with increased 30-days mortality, and the level of free hemoglobin in a first day of the disease has high sensitivity, specificity, and can determine the outcome of sepsis with accuracy up to 96.7 %.

Conclusion.Free hemoglobin concentration above medium size identified on the first day of the currents of severe sepsis, is directly related to increased 30-day mortality, and researched level of free hemoglobin in day 1 of the disease has a high proportion of sensitivity and specificity. Level of free hemoglobin is predictor outcome of sepsis in the first 24 hours after the start of therapy, but the results did not rule out the need to use the necessary test from septic patients, but rather the feasibility of combining the two dictates the criteria to assess the outcome of severe septic process that requires further research.
Comorbid pathology and patient reported outcomes in psoriatic arthritis: literature review
Authors: Fairushina I. F. , Abdulganieva D. I. , Mukhametshina E. I.
Published: December 2019

Psoriatic arthritis forms part of thespondyloarthritisspectrum and is characterized by heterogeneity of clinical picture. According to epidemiological studies, patients with psoriatic arthritis often suffer from numerous comorbidities, which affect the quality of life, impact on the response to therapy and are the main cause of increasing mortality. The studies assessing the relation between psoriatic arthritis course and comorbidity are in interest nowadays, because this issue has not been studied enough in comparison with other chronic inflammatory arthritis. Comorbidity includes cardiovascular diseases, diabetes mellitus, obesity, metabolic syndrome, osteoporosis, liver diseases, inflammatory bowel disease, depression, etc. Timely diagnosis and control of comorbidity will reduce the development of complications and improve clinical outcome.
Safety of infliximab in real clinical practice
Authors: Aronova E. S. , Lukina G. V.
Published: December 2019

A wide range of highly effective genetically engineered biological preparations introduced into clinical rheumatology in recent years causes a special interest in their safety.

Purpose of the study. Evaluation of the safety of infliximab therapy in patients with rheumatoid arthritis.

Materials and methods. The authors' own data, which analyzed the undesirable effects of infliximab in 135 patients with rheumatoid arthritis in actual clinical practice, are presented. A case report of the adverse reaction of combination therapy with leflunomide and infliximab is presented.

Results and its discussion. The overall tolerability of infliximab was satisfactory. Adverse events were observed in 28.1 % of cases, including 19.1 % of patients (14.1 %) had serious side effects that required discontinuation of the drug.

Findings. In most cases, infliximab is safe for use in actual clinical practice. Patients should be informed about the risks of undesirable effects and the need for a rheumatologist's examination before each infliximab administration before prescribing therapy.
Modern approach to diagnosis of idiopathic lobular panniculitis (Weber‑Christian disease)
Authors: Egorova O. N. , Belov B. S. , Radenska-Lopovok S. G.
Published: December 2019

Idiopathic lobular panniculitis (ILP or Weber‑Christian disease) is the least studied disease in the group of systemic connective tissue lesions and is characterized by systemic lesions of subcutaneous fat. The examination of 67 patients (9 men and 58 women aged 20 to 76 years) with a verified diagnosis of ILP allowed to identify the main clinical and laboratory signs of ILP.
Pathogenetic aspects in treatment of chronic generalized parodontitis in adolescents with idiopathic scoliosis
Authors: Galkinа O. P. , Zhadko S. I. , Kushnir K. G.
Published: December 2019

The aim of the study was the increase of the effectiveness of treatment and preventive measures in adolescents with generalized parodontitis of mild severity, suffering from idiopathic scoliosis with varying degrees of spinal deformity. The scheme of dental assistance, due to peculiarities of the underlying disease is unified. As a pathogenetic component of the systemic treatment of parodontitis, the antihomotoxic preparation Osteobios has been proposed and tested. Using ultrasound osteodensitometry, we analyzed the indicators of the structural and functional properties of bone tissue before and after treatment of parodontitis. The correcting effect of the preparation Osteobios of metabolic disorders in bones tissues in the near term of observation was established.
Analysis of dentists’ awareness practicing dental implantation in relation anatomical structures of upper and lower jaws
Authors: Avanesov A. M. , Sergeev N. I. , Nudnov N. V. , Sedov Yu. G.
Published: December 2019

Conduction of any surgical operation requires the knowledge of anatomy of this area, the installation of dental implants can cause some complications, including sensorineural disorders and bleeding. One of the causes for this is the lack of awareness of dentists regarding clinically significant structures. The aim of this work was to analyze the awareness of dentists regarding anatomical risk factors.
Planning of treatment in patients with orthodontic profile with registration of topography of key teeth
Authors: Shkarin V. V. , Lepilin A. V. , Fomin I. V. , Domenyuk D. A. , Dmitrienko S. V.
Published: December 2019

Aim. Determination of the position of the central point and canines in patients with anomalies in the shape and size of dental arches. Materials and methods. The materials of the research were the results of measurements of diagnostic gypsum models of dental rows of 63 people of the first period of adulthood with a full set of permanent teeth, physiological occlusion and 59 people with shape anomalies, the size of dental arches of the same age period. The width of the crowns of the teeth was measured in the mesial-distal direction. The width of the dental arch was determined between the points located on the vestibular distal tubercles near the occlusal contour of the crowns. The frontal-distal and canine diagonal was measured from the central point located between the medial incisors near the cutting edge to the points located on the molars and canines, respectively. The depth of the dental arch was determined from the central intercellular point to the line joining the antimers, in particular canines and molars. Results. Taking into account morphological, clinical studies and mathematical modeling, an algorithm for examining patients with anomalies in the shape and size of dental arches has been developed, which makes it possible to reveal the position of the central (inter cut) point. The basis of the algorithm is the measurement of the width of the dental arch between the second molars and the value of the front-distal diagonal, defined as the ratio of the half sum of 14 teeth to the coefficient of 1.04. It is established that the location of the canines is determined from the size of the frontal canine diagonal calculated as the ratio of the diagonal of the dental arch to the ratio of the length of the dental arch to the sum of the width of the crowns of six anterior teeth and using a correction factor of 0.1. Conclusion. Improving the methods of diagnosis of dentoalveolar anomalies allows not only minimizing errors associated with instrumental measurement techniques, but, due to the predictability of orthodontic treatment, to achieve optimal functional and aesthetic results. The introduction of the algorithm will, with a high degree of certainty, establish the position of the central point and key teeth. The use of these guidelines in patients with anomalies in the shape, size of the dental arches, due to a reasoned choice of tactics and the volume of manipulations conducted, will reduce the time spent in the diagnostic phase.
Nab-paclitaxel in Treatment of Metastatic Breast Cancer
Authors: Kovalenko E. I. , Artamonova E. V.
Published: December 2019

Despite the development of new systems for the treatment of metastatic breast cancer (mBC), chemotherapy remains an integral and significant stage of treatment for any molecular tumor subtype. In accordance with modern concepts, the optimal strategy of therapy in the vast majority of cases of mBC is the sequential administration of cytostatics in mono modes. This approach allows long-term control of tumor growth, translating pathology into a chronic discharge and maintaining a high quality of life. The emergence of new drugs or innovative dosage forms of existing cytostatics expands the possibilities of treatment of this chronic disease and allows long-term control over the disease. One of such new options was nab-paclitaxel, nano-dispersed paclitaxel stabilized with albumin. This dosage form provides active transport of the drug through the vascular endothelium with the creation of its high concentration in the tumor tissue. Clinical studies comparing nab-paclitaxel with traditional taxanes (paclitaxel and docetaxel) demonstrated high efficacy and safety of the drug both in a wide population of patients and in individual subgroups, including patients previously treated with anthracycline taxane, cases with aggressive disease, lesions of visceral organs, elderly patients and others. In addition, due to its unique formula, the drug does not cause hypersensitivity reactions, differing from traditional These taxanes are easy to use and safe. The lack of need for premedication with dexamethasone allows it to be prescribed for such comorbidities as severe hypertension, diabetes mellitus, stomach ulcer and duodenal ulcer, etc., and also successfully combine it with inhibitors of control points of the immune response, which confidently removes the drug on arena of immuno-oncology.
Modern ideas about cluster headache. Literature review
Authors: Savitskaya A. , Filatova E. G.
Published: December 2019

The article presents a review of the literature where, starting with the publication of Ekbom K. (1947), the history of the allocation of cluster headache into a separate form of primary head pain is described, modern diagnostic criteria are presented, the pathogenesis, clinical features of the disease are described. It is shown that due to the rarity of this type of headache and low awareness of doctors, the delay in diagnosis is on average 6–7 years. Patients are prescribed a lot of unnecessary examinations and expert consultations: oculists, ENT doctors, neurosurgeons, psychiatrists, etc. Favorite incorrect diagnoses are migraine and trigeminal neuralgia. The evidence of the leading role of the hypothalamus in the pathogenesis of cluster headache is presented. The principles of therapy are discussed: for the relief of acute attacks, triptans are used as in migraine, the leader of prophylactic therapy is a calcium channel blocker verapamil. In chronic forms and attacks resistant to pharmacological treatment, neurostimulation methods are used.
Effectiveness of UVB-therapy with 311 nm wave-length and tacrolimus in treatment of psoriasis in children
Authors: Turovskaya S. N. , Matushevskaya E. V.
Published: December 2019

Relevance. Of particular relevance in recent years has become the problem of psoriasis in children, it is noted an increase in cases of severe psoriasis refractory to traditional drug therapy, which together with a high incidence raises the questions of optimization of therapeutic interventions in this category of patients in the category of social.

The purpose of the study. To study the efficacy and safety of UVB-phototherapy 311 nm, tacrolimus from pediatric patients with psoriasis.

Material and methods. Under supervision there were 26 patients from 5 to 16 years old. All patients received UVB 311 nm phototherapy. The effectiveness evaluated in accordance with the dynamics of the indexes PASI, BSA, Quality of Life.

Results. As a result of the course of UVB-therapy with 311 nm wave-length the number of patients with PASI 100 was 69 %, PASI 90 was 23 %, PASI 75 was 8 %. Index BSA were thus reduced to 81.5 %, DIKE improved by 65.3 %. The tolerance to UVB 311 nm was evaluated as very good. Adverse reactions such as transient erythema was observed in 11.5 % of patients, xerosis in 19.2 %.

Conclusion. UVB 311 nm phototherapy is a highly effective and safe method of therapy of medium-severe psoriasis in children.
New horizons in systemic therapy of acne
Authors: Kruglova L. S. , Gryazeva N. V. , Nazarenko A. R.
Published: December 2019

According to some authors, systemic corticosteroids can be used at the beginning of the course of treatment, which helps to accelerate the achievement of a significant effect and reduces the severity of side effects of retinoids. However, many issues of the combined use of isotretinoin and systemic corticosteroids in terms of the methodological approach remain unclear, which determined the purpose of this research.

Material and methods. We observed 84 patients with moderate to severe acne. Among them, 51 (60.7 %) women and 33 (39.3 %) men, the average age of the patients was 17.1 ± 1.8 years. Patients were divided into 2 groups: moderate severe course — 1 group (n = 40), severe acne — 2 group (n = 44). Within the groups, depending on the therapy, the patients were divided into 2 subgroups: A subgroup — received isotretinoin in standard dosages, B subgroup — received isotretinoin also in standard dosages, while the initiation of therapy was carried out while taking systemic corticosteroid (1 month dexamethasone was prescribed at a dose 1 mg / day in 1 dose (in the morning)).

The results of the study. The dynamics of the DICI index, the global IGA score, DICI showed comparable efficacy results in long-term follow-ups and early differences, an advantage was noted in the groups treated with dexetozone.

Findings. Systemic retinoid is effective in preventing the formation of post-acne scars, which allows us to recommend it as the first choice in patients with risk factors for scar development. Important factors in the effectiveness of isotretinoin and the prevention of relapse are individual dose selection, the total cumulative and single dose and the duration of therapy for at least 6 months. The data obtained showed that the administration of a systemic corticosteroid in low doses (1 mg / day of dexamethasone) for 1 month of taking isotretinoin improves the effectiveness of therapy in the early stages of therapy and reduces the frequency / severity of side effects of retinoids.
Algorithms for providing medical care to patients with acute respiratory viral infections
Authors: Nikiforov V. V. , Suranova T. G. , Orlova N. V. , Kardonova E. V. , Smetanina S. V.
Published: December 2019

Acute respiratory viral infections are of great socio-economic importance due to their high prevalence and severe consequences. The article presents recommendations for the treatment of various forms of influenza and other acute respiratory viral infections. Considered tactics of patient management, depending on the severity and the presence of complications, determined the indications for hospitalization, discussed the issues of pathogenetic and symptomatic therapy. Immunoprophylaxis is important in reducing the incidence and mortality from influenza. The article describes the indications for vaccination, risk groups, features of modern vaccines.
Psychoemotional stress in review of ESC/ESH recommendations for treatment of hypertension (2018) and clinical trial results
Authors: Orlova N. V. , Starokozheva A. Ya. , Тимощенко А. В.
Published: December 2019

Psychoemotional stress is a risk factor for cardiovascular disease. The ESC/ESH recommendations for the treatment of hypertension (2018) define psychological stress as a risk factor for hypertension. The basis of hypertension of the ‘white coat’ and masked hypertension are considered psychosocial factors. Stress causes early damage to target organs and uncontrolled blood pressure. The article discusses the mechanisms of formation of arterial hypertension under the influence of stress. On the example of clinical studies, the negative role of psycho-emotional stress in extreme professions is considered. The data of their own research on the effect of stress in locomotive drivers on the development of cardiovascular diseases are presented.
Design of method for detecting single nucleotide polymorphisms of DNA non-coding region rs17185536: potential diagnostic value
Authors: Gorbenko A. S. , Stolyar M. A. , Komarovsky Yu. Yu. , Mikhalev M. A. , Potylitsyna V. V. , Vasilyev E. V. , Olkhovsky I. A.
Published: December 2019

A large-scale study of DNA sequencing databases (Jorgenson E., et al., 2018) to search for hereditary susceptibility to early erectile dysfunction revealed an association with the rs17185536-T polymorphism regulating the expression of topologically associating domain, among which is the SIM1 gene, which plays an important role in maintaining mass body and sexual function. The proximity of the rs17185536 locus to the CCNC (cyclin C), PRDM13 (histone methyltransferase) and USP45 (ubiquitin-specific peptidase 45) genes suggests the possible involvement of this polymorphism in the pathogenesis and other diseases associated with impairments of these genes.

Materials and methods. The study included a total of 280 people: 81 of which were healthy donors, 116 pregnant women, 25 patients with polycythemia vera, 29 with essential thrombocythemia, and 29 with primary myelofibrosis.

Results. Using the original method of determining the polymorphism rs17185536, the allele of specific PCR-RT showed that the prevalence of the T allele among all examined patients was 19 %, and variants of the genotypes: C/C with 73 %, C/T with 23 % and T/T with 4 %, which corresponds to Winkler e. a. data. The absence of statistically significant differences in the frequency of occurrence of this polymorphism in the pathology of pregnancy and in chronic myeloproliferative diseases indicates a low probability of involvement of rs17185536-T in the pathogenesis of these diseases. In the group of pregnant women, there is an association of the rs17185536-T allele with obesity, uterine fibroids and the development of preeclampsia.

Conclusions. For the first time, using the original method of analysis, it was confirmed that the Russian population has a comparable prevalence of the gene of hereditary susceptibility to impotence. Despite the topographic proximity of the rs17185536 locus to the genes regulating the repair and functioning of DNA, its polymorphisms do not affect the risk of chronic myeloproliferative diseases developing. The association of the rs17185536-T allele with the risk of developing a pregnancy pathology requires further study.
Possibility of determining patients with chronic obstructive pulmonary disease at ambulatory treatment by dentist
Authors: Kulbachinsky N. V. , Brailovskaya T. V. , Bart B. Ya.
Published: December 2019

Detection of persons suffering from chronic obstructive pulmonary disease was carried out among patients who received scheduled and urgent surgical dental care on an outpatient dental appointment. At the first stage, a questionnaire was conducted for patients with dentition defects that needed orthopedic treatment, and patients who planned surgical manipulations with subsequent planned prosthetics, including those based on intraosseous implants. Patients with previously verified COPD, clinical signs of the disease (respiratory symptoms) and a high probability of its presence were sent to the physician-therapist for targeted standardized screening and diagnosis clarification. 978 patients were questioned, 256 patients were identified, subject to targeted standardized screening. COPD was verified in 95 patients (n = 95), which was 9,7 % of the total number of questionnaires (n = 978) and 37 % of the number of patients who underwent targeted screening (n = 256).
Quality of life for women with endometriosis and communication strategy with them
Authors: Burchakov D. I. , Burchakova M. N. , Kuznetsova I. V.
Published: December 2019

Endometriosis is a chronic disease with a pronounced psychosomatic component. Women with endometriosis have their own characteristic portrait. The article discusses modern ideas about endometriosis as a factor affecting a woman’s personality, her family relationships, the quality of her sleep, and, finally, communication with a doctor. The approaches to building a productive dialogue with patients with endometriosis, methods of increasing adherence to therapy, the advantages of oral contraception with dienogest in the treatment of endometriosis are examined in detail.
Treatment and prevention of hand-foot skin reaction — dermatological adverse effect of regorafenib (literature review)
Authors: Shatokhina E. A. , Kruglova L. S. , Nosikova P. G.
Published: December 2019

Regorafenib is an agent of targeted cancer therapy, that is a multikinase inhibitor of angiogenesis, oncogenesis, microenvironment and tumor immune system. Due to the unique mechanism of action, regorafenib is highly effective in the treatment of various tumors. The most common adverse event associated with regorafenib, leading to a dose reduction or its cancellation, is a manifestation of skin toxicity — hand-foot skin reaction. The review compiles published data based on research and experience in managing this dermatological adverse event. Adequate staff and patient awareness, monitoring, prevention, and treatment are necessary to reduce the incidence, duration, and severity of hand-foot skin reaction associated with regorafenib. Determining the optimal management for patients with this complication becomes an essential component of the complex treatment of patients receiving regorafenib anti-tumor therapy, especially considering the fact that hand-foot skin reaction is a marker of its effectiveness.