bluuebunny/crossref_metadata_2025 huggingface dataset:
Essere esseri umani. Il coraggio di Mariasilvia Spolato
Authors: Focardi Giovanni , Da Lio Nicolò , Mansi Adriano
Published: November 2024

Mariasilvia Spolato nasce nel 1935 e muore il 31 ottobre 2018. Pochi giorni dopo, sui mass media, alcuni articoli ne ricordano la vita, il ruolo da protagonista nel nascente movimento omosessuale italiano e il successivo oblio. Ancora oggi (giugno 2021) alcune pagine web dedicate a lei e alla sua vita, contengono diverse informazioni sbagliate e lacunose, così come alcuni video che circolano in rete sono punteggiati da altrettanti errori o ricostruzioni agiografiche. Con questo articolo ci proponiamo due obiettivi: 1) descrivere con maggior precisione e completezza tutte le fasi della vita di Spolato, sulla scorta di un’ampia quanto variegata documentazione (tratta da archivi, stampa, testimonianze orali) intrecciandole con le trasformazioni sociali e culturali della storia dell’Italia; 2) riflettere sulle narrazioni scaturite dopo la notizia della sua scomparsa.
Le politiche monetarie del fascismo in Somalia dall’assimilazione alla caduta dell’impero (1925-1941)
Authors: Sessa Claudio
Published: November 2024

Il 1925 rappresentò per l’Italia l’inizio di una nuova fase storico-politica con la definitiva fascistizzazione delle istituzioni e della società. Sul piano coloniale la Somalia italiana fu interessata da un’intensa attività di riforma che coinvolse tanto l’ambito politico-militare quanto quello economico-finanziario. In modo particolare il settore monetario subì i più profondi cambiamenti che ebbero importanti ricadute sugli equilibri finanziari della colonia stessa.
La narrazione storica nei videogiochi: il caso di Sid Meier’s Civilization
Authors: Lapsus Laboratorio
Published: November 2024

La ricezione delle concezioni e dei messaggi insiti nei videogiochi nonché il loro impiego nella didattica, hanno già rappresentato un terreno di indagine in diverse discipline delle scienze sociali. Tuttavia, il medium videoludico sconta ancora una scarsa considerazione da parte degli storici e fatica ad accreditarsi come vero e proprio oggetto di indagine, sebbene esistano molti titoli a tema storico. In tale margine non presidiato, stereotipi, falsi storici e narrazioni distorte hanno potenziale spazio per proliferare. Il contributo intende analizzare le eredità e gli immaginari della saga Civilization di Sid Meier, considerato uno dei videogiochi di strategia a tema storico più celebri nel mondo.
Storia in gioco? Uno studio di Total War: Attila
Authors: Gonzato Gian Luca , De Marchi Lorenzo
Published: November 2024

Lo scopo dell’articolo è di condurre un’analisi critica del videogioco Total War: Attila. L’historical game sarà qui considerato come un’interpretazione del passato, sulla quale è possibile sviluppare diverse critiche su molteplici livelli. Dopo aver analizzato il contenuto del titolo videoludico, si osserverà in che modo Total War: Attila si possa porre quale strumento autonomo di esplorazione del passato. Infine, il videogioco sarà studiato in un’ottica di Digital Public History. Con l’analisi della pratica del modding e attraverso lo spoglio di un forum di una singola mod total conversion – la Medieval Kingdom 1212 A.D. – si osserverà come in rete avvenga il contatto tra videogiocatori e storia.
Aportes históricos al campo de la museología argentina
Authors: González Virginia Fernanda
Published: November 2024

El presente trabajo pretende esbozar qué sucedió con la museología entre 1950 y 1980 en Argentina, específicamente en Buenos Aires, donde el contexto político y social fue de agitación e inestabilidad. Allí, los museos jugaron un papel fundamental en la estructuración de la búsqueda de una identidad nacional, ya que fueron las entidades que respaldaron los discursos políticos de cada momento, ayudaron a transformar la disciplina y sostuvieron a las figuras que conformaron el campo. A consecuencia de todo esto, surgió la disciplina museológica como una necesidad de dar respuesta al complejo funcionamiento de la gran cantidad de museos que se fueron creando.
Museología y (mito)poética: Revisando los debates del ICOFOM con nuevas contribuciones teóricas y prácticas
Authors: Melo Diogo Jorge de , Teixeira do Carmo Lopes Isabel Cristina , Barroso Gisele Nascimento , Souza dos Santos Cássio Alexandre
Published: November 2024

Este trabajo revisa las concepciones sobre la relación entre museología y poética a partir de los debates del ICOFOM y realiza una discusión sobre el concepto de mitopoética. También presenta un estudio de caso del Museo Virtual Surrupira de Encantarias Amazónicas, que se desarrolla como un experimento museístico y se apoya en el concepto de mitopoética. Se aborda así una lectura crítica de las producciones del ICOFOM, principalmente de ICOFOM Study Series 46 de 2018. En este se presentaron los resultados del Simposio del ICOFOM 2017, organizado en Cuba, con el tema “Política y Poética de la Museología.” Con esta discusión y aportes decoloniales, el artículo busca resaltar la importancia de lo imaginario y la mitopoética en el contexto de los museos y la museología, demarcando avances transformadores basados en los devaneos, los sueños, las locuras y las artes.
The legacy of Santiago de Chile in ICOM publications
Authors: Galassini Anna-Lou , Bergeron Yves , Duarte Cândido Manuelina Maria
Published: November 2024

In recent years, the Round Table of Santiago de Chile has been mentioned a lot, particularly in light of its 50th anniversary in 2022. These multiple celebrations might suggest that its values have been in the international spotlight since its promulgation in 1972. However, the lively debates in Kyoto in 2019 over the proposed modification of the definition of the term “museum” suggest the opposite, demonstrating a less-than-unanimous acceptance of the Round Table’s values and almost suggesting its late arrival on the international scene. To gain a better understanding of the impregnation of its values, we have carried out the exercise of counting mentions of the Santiago Round Table within ICOM publications. This work provides a partial but revealing overview of the phenomenon and demonstrates that that the statements formulated at the Santiago Round Table seem to be gradually being largely integrated into the field of museology.
Developing museological methodologies for unpacking colonial legacies in Barbados
Authors: McGuire Natalie A.
Published: November 2024

Recent discussions in museology highlight the need for museums to move beyond neutrality and actively engage in shaping social ideologies and addressing contentious histories. This paper focuses on the Anglophone Caribbean, where museums have traditionally followed chronological and reductive interpretive models, often overlooking critical discussions on race and colonialism. Using the Barbados Museum & Historical Society as a case study, it explores the evolution of museology in the region and the challenges in addressing colonial legacies, particularly regarding the Afro-Caribbean experience. By unpacking colonial frameworks in curatorship and promoting decolonial/anticolonial content, this paper advocates for a more profound analysis of historical narratives and a shift towards reparative dialogue within the Anglophone Caribbean museological landscape. It underscores the ongoing anticolonial journey and the importance of community-led initiatives in challenging entrenched colonial ideologies.
Abusive Work Environment Effect on Female Entrepreneurs' Emotional Wellbeing by Mediation of Social and Moral Values in the Horn of Africa
Authors: Adula Metasebia , Kant Shashi , Badi Sofi , Kumari Mona
Published: November 2024

This chapter investigates the impact of an abusive work environment on the emotional well-being of female entrepreneurs in the Horn of Africa, with a focus on the mediating role of moral and social values. Using a sample of 400 female entrepreneurs, the study assesses whether the dataset is suitable for factor analysis using the Kaiser-Meyer-Olkin (KMO) measure. An exploratory factor analysis (EFA) is used to identify key ideas related to workplace mistreatment, moral and social values, and mental wellness. Next, the factor structure is confirmed and the reliability of the measuring devices is confirmed using Confirmatory Factor Analysis (CFA). Next, using structural equation modeling (SEM), the relationships between these variables are investigated, with an emphasis on the effects of an abusive work environment on emotional well-being and the findings indicate that abusive work conditions have a detrimental effect on the mental health of female entrepreneurs, but that these impacts can be mitigated by strong moral and social values.
Deceleration of denervated facial muscle atrophy through functional electrical stimulation: a sonographic quantification in patients with facial nerve paralysis
Authors: Meincke Gabriel , Krauß Johannes , Geitner Maren , Kuttenreich Anna-Maria , Arnold Dirk , Ballmaier Jonas , Lehmann Thomas , Mayr Winfried , Guntinas-Lichius Orlando , Volk Gerd Fabian
Published: November 2024

Functional Electrical Stimulation (FES) is an established intervention for a range of muscular and neurological disorders that has already been studied in numerous publications. However, its application to Peripheral Facial nerve Paralysis (PFP) still needs to be sufficiently investigated. As the first approach known to the authors, this study examines the effect of FES on the facial muscles in complete PFP using ultrasonography as a means of observation. In a prospective single-center observational pilot study, ten patients with complete PFP, confirmed by needle-electromyography (EMG), performed FES of the affected lateral mouth region at home twice daily for 20 minutes. The facial muscles’ Cross-Sectional Area (CSA) was regularly assessed using sonographic quantification. While the CSA of most non-stimulated muscles decreased considerably during ongoing paralysis, a significant CSA increase of the Zygomaticus Muscle (ZYG), which was regularly subjected to FES, could be demonstrated. FES can halt the atrophy of denervated ZYG and potentially other facial muscles. Further investigations with a more significant patient collective are recommended. From now on, FES could be established as an additive method in the non-invasive treatment of PFP.
Intimate Partner Violence among Female Spouses of Men with Alcohol Dependence Syndrome: A Cross-sectional Study
Authors: Periyasamy Chinnadurai , Narayanan Gitanjali , Kandasamy Arun , Ezhumalai Sinu , Shanmugam Backiyaraj
Published: November 2024

Background:

Worldwide, intimate partner violence (IPV) is a serious public health threat to women’s mental health. Female spouses of men with alcohol dependence often face various forms of abuse. IPV is widely prevalent among women who are married to men with alcohol dependence. However, the prevalence of IPV among female spouses of men seeking treatment for their alcohol dependence is unclear.

Methods:

A cross-sectional study design was used. A total of 110 female spouses of men with alcohol dependence syndrome were selected using purposive sampling from the Centre for Addiction Medicine, National Institute of Mental Health and Neurosciences, Bengaluru, India. A Composite Abuse Scale-Short Form was used to assess the prevalence and pattern of IPV. The interview method was used to collect the data. Independent sample ‛t՚ test and logistic regression analysis were used to analyze the data.

Results:

The mean age of participants is 33 years (±6.34). Most (85.5%) participants experienced different forms of IPV. Prevalence for physical violence was 82.7%, followed by psychological violence (76.4%). Nearly, one-third of the participants (30%) reported sexual violence, and similarly, close to one-third (30%) experienced all forms of IPV. Men who were involved in gambling had significantly higher IPV toward their wives than nongamblers. The employment status among female spouses and urban domicile strongly predicted IPV.

Conclusion:

The prevalence of IPV among female spouses of men with alcohol dependence is 85.5%. Evidence-based psychiatric social work interventions need to be provided to address IPV among wives of persons with alcohol dependence in routine clinical practice at de-addiction centers.
Comparative Efficacy of Intracanal Medicaments in Healing Apical Periodontitis: Insights from a Comprehensive Clinical Study
Authors: Johnson G. Priya , Kataria Shruti , Penumaka Sravana Laxmi , Ameer Bilal , Mohammed Abdul Sattar , Murugesan Sabari
Published: November 2024

ABSTRACT

Background:

Apical periodontitis is a prevalent condition that necessitates effective intracanal medicaments for successful endodontic therapy.

Materials and Methods:

A randomized controlled clinical trial was conducted on 120 patients diagnosed with apical periodontitis. The patients were randomly assigned to three groups, Group A (calcium hydroxide), Group B (triple antibiotic paste), and Group C (chlorhexidine gel), with 40 patients in each group. Each medicament was placed in the root canal after standard endodontic procedures, and the patients were evaluated at 1, 3, and 6 months using radiographic assessment and clinical examination. The primary outcome measure was the reduction in lesion size, and secondary outcomes included pain relief and healing time.

Results:

After 6 months, Group B (triple antibiotic paste) showed the highest reduction in lesion size, with an average decrease of 75%, followed by Group C (chlorhexidine gel), with a 60% reduction, and Group A (calcium hydroxide), with a 50% reduction. Pain relief was observed in 85% of patients in Group B, 75% in Group C, and 65% in Group A. The average healing time was the shortest in Group B (4 months), compared to Group C (5 months) and Group A (6 months).

Conclusion:

Triple antibiotic paste demonstrated superior efficacy in healing apical periodontitis compared to calcium hydroxide and chlorhexidine gel.
Effectiveness of PRP in Reduction of Localized Alveolitis in Young Adult Patients
Authors: Deshpande Archana D. , Dubey Vertika , Venkateshwar Gokul , Ponnamma  , Maghu Sahil , Rahman Sadaf
Published: November 2024

ABSTRACT

Background:

Localized alveolitis, commonly known as dry socket, is a painful post-extraction complication that occurs when the blood clot at the site of the tooth extraction disintegrates. Platelet-rich plasma (PRP), an autologous concentration of platelets in plasma, has been proposed to enhance wound healing and reduce the incidence of alveolitis.

Materials and Methods:

This randomized controlled trial included 100 young adult patients aged 18-35 undergoing mandibular third molar extractions. The patients were randomly assigned to the PRP group (n = 50) or the control group (n = 50). In the PRP group, PRP was prepared from the patient’s blood and applied to the extraction site immediately after tooth removal. In the control group, no additional treatment was applied. The primary outcome was the incidence of localized alveolitis within 7 days post-extraction. Secondary outcomes included pain levels assessed using a visual analog scale (VAS) and wound healing evaluated clinically.

Results:

The incidence of localized alveolitis was significantly lower in the PRP group (6%) compared to the control group (20%) (P < 0.05). Patients in the PRP group reported lower pain scores on the VAS at 3 and 7 days post-extraction, with mean scores of 2.5 and 1.2, respectively, compared to 4.0 and 2.8 in the control group. Clinical evaluation showed enhanced wound healing in the PRP group, with fewer signs of inflammation and better epithelialization.

Conclusion:

The application of PRP significantly reduces the incidence of localized alveolitis and accelerates wound healing in young adult patients following mandibular third molar extractions. PRP is a promising adjunctive treatment that enhances postoperative recovery and patient comfort.
Comparison of Intrusive Effects and Amount of Root Resorption in Maxillary Incisors Using Two Conventional Intrusion Arches and Mini-Implants
Authors: Vinu Shilpa , Vadher Virendra , Nair Arvind , Baxi Shalabh , Singh Shweta , Barapatre Chhaya
Published: November 2024

ABSTRACT

Aim and Objective:

This study aimed to compare the amount of maxillary incisor intrusion and root resorption using three methods: mini-implants, utility arches, and Connecticut intrusion arches.

Materials and Methods:

Eighteen patients aged 15 to 25 years with deep bite were divided into three groups: 10 patients each for mini-implant, utility arch, and Connecticut intrusion arch groups. Bilateral mini-implants were used in Group 1, while utility and Connecticut arches were used in Groups 2 and 3, respectively. Intrusion was performed over four months. Lateral cephalograms and orthopantomograms were taken at the start (T1) and after four months (T2).

Results:

The mean incisor intrusion measured by U1-PP was 2.08 mm in Group 1, 1.55 mm in Group 2, and 1.75 mm in Group 3 (P < 0.05). CR-PP measurements showed 1.91 mm in Group 1, 1.56 mm in Group 2, and 1.66 mm in Group 3 (P < 0.05). Incisors in Group 1 showed minimal protrusion compared to significant protrusion in Groups 2 and 3 (P < 0.05). Maxillary molars showed no significant changes in Group 1 but distal tipping in Groups 2 and 3 (P < 0.05). No root resorption was observed in any group.

Conclusion:

Mini-screws demonstrated the most effective maxillary incisor intrusion with minimal side effects compared to utility and Connecticut intrusion arches.
Evaluation of Propolis, Aloe Vera Gel, Noni, Pomegranate Juice Natural Storage Medium for Management of Avulsed Teeth
Authors: Sahoo Sanjit Kumar , Vempalli Swetha , Awinashe Minal , Shah Shahzad Ali , Salama Mohamed Tharwat , Abraham Sajith , Shetty Mukul , Ghosh Shaili
Published: November 2024

ABSTRACT

Objectives:

To ascertain the effectiveness of propolis, aloe vera gel, noni, and pomegranate juice natural storage solution in preserving the vitality of avulsed teeth PDL cells.

Materials and Methods:

Forty recently extracted human premolars that were recommended for orthodontic purposes were used in the current investigation. Each of the four storage medium groups (N = 10)—Group A: propolis, Group B: pomegranate juice, Group C: aloe vera, and Group D: noni—was assigned to them at random. The teeth were immersed in one of the three experimental media for forty minutes after being dried for twenty-five minutes at room temperature. Each tooth’s root surface was treated with an enzymatic solution containing 1 mL of Collagenase Type II and Dispase Type I in phosphate buffer saline following drying and soaking. Following the application of 0.4% Trypan blue labeling, the cells were counted using a hemocytometer under a 10x light microscope magnification. The obtained data was statistically analyzed.

Results:

The samples placed in propolis indicated the maximum number of viable PDL cells subsequently pomegranate juice, aloe vera gel, and noni. There was considerable disparity in the amount of viable PDL cells among the groups.

Conclusion:

The current research findings suggest that propolis, pomegranate juice, aloe vera gel, and non-natural media can be employed to preserve the viability of PDL cells in avulsed teeth.
Assessment of Serum Adiponectin and Leptin in Chronic Periodontitis Over Healthy Individuals
Authors: Preethanath Reghunathan S. , Chandy Swaroop , Syed Nubesh Khan , Shankar Bugude Shiva , Seshadri Pavithra Rangarajan , Narayane R , Bai P. K. Saraswathi
Published: November 2024

ABSTRACT

Objective:

The objective of the research was to ascertain whether serum levels of the biochemical markers adiponectin and leptin are related to clinical periodontal characteristics.

Materials and Method:

For the study, 20 people with chronic periodontitis (Group A) and 20 healthy people (Group B) were enrolled. Assessments were conducted on periodontal markers, including bleeding on probing (POP), gingival index (GI), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL). An enzyme-linked immunosorbent assay (ELISA) test was used to assess the levels of adiponectin and leptin in serum samples.

Result:

There was significant elevation in average level of leptin in chronic periodontitis in association to that in healthy group. On the other hand, there was considerable decrease in serum adiponectin in group A in association to healthy group. The ratio of leptin\adiponectin was appreciably greater amongst periodontitis group compared to healthy group.

Conclusion:

The current investigation leads us to the conclusion that the pathophysiology of periodontitis is significantly influenced by serum levels of adiponectin and leptin.
Novel Techniques to Manage Temporomandibular Disorders – A Multidisciplinary Approach
Authors: Shah Mehul A. , Deshmukh Kunal Shankarrao , Dash Kabir Suman , Agrawal Shafali , Mishra Ankita , Kamath Vignesh
Published: November 2024

ABSTRACT

Temporomandibular joint is a compound, bilateral, ginglymoarthroidal joint articulating the condyle to temporal glenoid fossa. TMDs often project a constellation of signs and symptoms. Therefore, the treatment plan for TMD’s should be more holistic. Current literature supports the interrelationship between chronic pain and behavioral, psychological, and psychosocial factors. This review elicits various treatment strategies for TMD’s and emphasizes combination of various therapies in resolution of pain and discomfort in patients with such disorders.
The Impact of Sira Vedha (Phlebotomy) at the Right Elbow Joint in the Treatment of Non-Alcoholic Fatty Liver Disease - A Research Report
Authors: Sawarkar Gaurav , Sawarkar Punam
Published: November 2024

ABSTRACT

Non-alcoholic fatty liver disease (NAFLD) affects 9%–53% of the Indian population. No Indian studies have examined Sira Vedha (phlebotomy) for NAFLD, although it has been studied for other conditions. Sushruta recommended Sira Vedha at the right elbow joint for liver diseases, but clinical evidence for its efficacy in NAFLD is lacking. This clinical trial aimed to generate evidence for Sira Vedha in NAFLD patients. One hundred eleven patients with Grade I/II NAFLD were randomly assigned to either a control group (diet and exercise) or an intervention group (Sira Vedha, diet, and exercise). Blood samples were collected for lipid profile and liver function tests before and after treatment. Results showed significant improvements in SGOT, SGPT, cholesterol, HDL, and triglyceride levels in the intervention group compared to the control group, supporting the efficacy of Sira Vedha in NAFLD treatment. This study highlights the need for clinical evidence to confirm traditional Ayurvedic practices.
Ayurvedic Approaches to Holistic Management of Polycystic Ovary Syndrome (PCOS)
Authors: Pardhekar Ashvini D. , Waskar Rohit , Pardhekar Abhilash , Deshpande Mayuri
Published: November 2024

ABSTRACT

The female reproductive system relies on the intact uterine adnexa and the hypothalamic-pituitary-ovarian axis. An imbalance can lead to pathogenesis. PCOS is characterized by ovarian cysts, hyperandrogenism, and irregular ovulation. Over time, it can lead to symptoms such as changes in menstruation, obesity, infertility, depression, and increased risk of diabetes, cardiovascular disease, and endometrial cancer. In Ayurveda, PCOS is a condition affecting Rasa, Rakta, and Medas, the three Dhatus. Rakta, Rasa, and Artavavaha are the Srotas that are implicated in this illness. Symptoms that may appear include Anartava (amenorrhea), Vandhyatwa, Pushpagni, and Abeeja Rutuchakra (an ovular hemorrhage). A 23-year-old woman presented at the outpatient department with complaints of irregular menstruation and rapid weight gain. An ultrasound revealed left-sided polycystic ovary syndrome (PCOS). Palliative treatments such as Kaklarakshak Yog, Trikatu, and Triphala Churna were administered for 2 months. The patient experienced a significant reduction in symptoms and a return to a normal menstrual cycle within two months.
Ayurvedic Management of Kitibhakushta (Guttate Psoriasis) – A Case Report
Authors: Deshmukh Sourabh , Thakre Trupti , Naukarkar Pawan R. , Pardhekar Ashvini
Published: November 2024

ABSTRACT

The skin disease in Ayurveda has been classified under Kushta, which is classified as Maha Kushta and Kshudra Kushta. Kitibha Kushta is type of Khudra Kushta. A 26-year-old male patient having brown rough-to-touch hard and dry lesions on a lower limb with itching for 2 years has been treated with Shodhan, followed by Shaman treatment. Shamanchikitsa included Gandhakrasayan and Panchatikta Ghrita after Shodhanchikitsa for 15 days and for local application for 1 month. By using the Ayurvedic modalities, we can find better results in Kushta.
A Neurological Disease, Vathatvartma (Ptosis), Managed with Integrated Management of Modern Science and Ayurveda – A Case Report
Authors: Bhutada Roshna , Rathi Mitali S.
Published: November 2024

ABSTRACT

Introduction:

Ptosis is when the upper eyelid droops downward. However, a droopy eyelid can cover the pupil and reduce vision in some cases. Causative factors may be congenital, injury or stretching of eyelid muscles or ligaments damage to the nerve controlling the eyelid muscles, aging, a complication of eye surgery, a complication of Botox injections.

Aim and objectives:

To study case of ptosis with integrated treatment of neurologist along with Ayurveda treatment.

Methodology:

Case Description - This is a 34year old female patient complaining that she is unable to open her right eye since11 days. She visited to local ophthalmologist, then they have consulted neurologist, MRI done, treatment started, at the same time patient wants to take Ayurveda treatment also. After 7th day visit to neurologist, she has stopped his medicine and told to continue alternative treatment So she consulted at MGACH&RC Salod on 4/3/2022. Her V/A right eye after uplifting upper lid by doctors hand is 6/6 and lt eye v/A is 6/6. Fundus of both was within normal limit. No diplopia, Acute onset with fronto orbital pain, pupil NSRL, conjugate left downgaze movement restricted.

Result and Discussion:

treatment prescribedshirodhara with brahmi and til tail, netratarpan with triphalaghruta, Tab Palsineuron 2 bd, Tab Ekangvirras 2 bd. - vatashamak Chikitasa is done as ptosis is neurological disease.after 7th day visit to neurologist, he has stopped his medicine and told to continue alternative treatment.

Conclusion:

The results were enthusiastic photographic depiction were taken. This case may be fruitful for further research on Nimesh/ Ptosis.
Effect of Blended Learning Method (Flex Model) on Final-Year Students of BAMS to Learn Shalyatantra
Authors: Shrivastav Pooja , Ghewade Babaji , Parwe Shweta , Asutkar Sheetal
Published: November 2024

ABSTRACT

Background:

Blended learning is a blend of online and in-person instruction. This study was conducted to see its effect to learn Shalyatantra topic.

Methodology:

Final-year students (58) were equally in two groups. The topic was taught using a conventional technique in group A and a blended learning way in group B. Pre-test and post-test were conducted before and after the study, respectively. Students’ and teachers’ perceptions on Likert scale were also taken. Statistical analysis was done.

Observation and Results:

The mean post-test score of group B, i.e. blended learning group (18.37 ± 0.97), was more as compared to group A, i.e. conventional learning group (16.31 ± 1.53). Individually both groups were statistically significant.

Conclusion:

It can be concluded that blended learning helped in developing critical thinking, communication skill in students, and enhance the retention of course content.
Evaluation of Flexural Strength and Vickers Micro Hardness of Three Different Denture Base Resin Materials
Authors: Mathar Mohammed Ibrahim , Chadha Manish , Soliman AlMoataz Mohamed Amin , Alharbi Saif H. , Karthik R. Murali , Mustafa Mohammed Ziauddeen
Published: November 2024

ABSTRACT

Objectives:

To evaluate the Vickers hardness and flexural strength of computer-aided design/computer-aided manufacture (CAD/CAM) milled, 3D-printed, and traditional heat-polymerized denture base resins used in computer-aided design and manufacture.

Materials and Methods:

A total of 60 samples were fabricated from CAD/CAM milled resin (PMMA dental material-Ruthinium disc, Badia Polesine (Rovigo) Italy), CAD/CAM 3D-printed resin (NextDent Denture 3D+, Soesterberg, The Netherlands) and conventional heat-polymerized (HP) denture base resin (DBR) (Triplex hot Ivoclar-Vivadent, Liechtenstein). Based on the three different denture base resin materials (n = 10/material) (30/flexural strength and 30/microhardness), the samples were split into six groups. The 3-point bending test was used to assess flexural strength, while Vickers microhardness test was used to assess surface hardness. The acquired data was statistically assessed.

Results:

CAD/CAM milled resins showed appreciably greater values for both the flexural strength and surface hardness, followed by conventional HP denture base resin and CAD/CAM 3D-printed resin. Pairwise comparison for Flexural Strength and Vickers microhardness revealed significant differences between groups.

Conclusion:

CAD/CAM milled resins had the highest surface hardness and flexural strength compared to Conventional HP denture base resin and CAD/CAM 3D-printed resin.
Management of Spinocerebellar Ataxia through Ayurveda—A Case Report
Authors: Sawarkar Punam , Yadav Natasha , Sawarkar Gaurav
Published: November 2024

ABSTRACT

Spinocerebellar ataxias (SCA) are neurodegenerative disorders marked by progressive cerebellar ataxia, impacting balance, motor coordination, and ocular function due to degeneration. This study evaluated Shodhana Chikitsa and Shaman Chikitsa (purification and symptomatic treatments) for SCA. A 27-year-old man with SCA, showing symptoms like swaying, poor balance, and slurred speech, was referred to the Panchakarma OPD at Ayurveda Hospital, Salod, Wardha. He underwent a comprehensive regimen, including full-body massage with herbal poultices (Patrapottali and Shashtishali Swedana), nasal instillation with medicated oil (Marsha Nasya), and a medicated enema with decoctions and oil, along with oral medications, such as Yogaraja Guggulu, Rasnasaptaka Qwath, Cap Neuron Plus, Agnitundi Vati, and Mahavatavidhwansa Rasa, for two months. Panchtikta Ksheer Vasti (medicated milk enema) was given for eight days. Significant improvements in symptoms and the Scale for Assessment and Rating of Ataxia (SARA) score were observed, suggesting that Ayurvedic treatments may be effective for SCA, warranting further research.
Comparative Study of Implant Placement Techniques and Their Effect on Long-Term Success of Implant-Supported Restorations
Authors: Nagar Priya , Husain Zakir , Gupta Utkarsh , Sheth Malav , Mishra Rahul , Muthuraj HL
Published: November 2024

ABSTRACT

Background:

The long-term success of implant-supported restorations is influenced by various implant placement techniques.

Materials and Methods:

This randomized controlled trial involved 120 patients requiring dental implants, divided into three equal groups based on the implant placement technique: Group A (conventional submerged), Group B (one-stage non-submerged), and Group C (guided surgery). All participants were followed for three years. The primary outcomes measured were implant stability (using implant stability quotient (ISQ) values) and marginal bone loss (using radiographic analysis). Secondary outcomes included patient satisfaction and prosthetic complications.

Results:

The study results demonstrated significant differences among the implant placement techniques. Group C (guided surgery) exhibited the highest mean implant stability, with an ISQ value of 75.4, outperforming Group B (one-stage non-submerged) at 73.2 and Group A (conventional submerged) at 71.5. In terms of marginal bone loss, Group A demonstrated the greatest loss at 1.5 mm, whereas Group B and Group C experienced less bone loss, measuring 1.1 mm and 0.9 mm, respectively. Patient satisfaction scores were highest in Group C, with an average of 9.2 out of 10, followed by Group B at 8.7 and Group A at 8.3. Additionally, Group A recorded the highest incidence of prosthetic complications at 15%, compared to 10% in Group B and 5% in Group C, highlighting the superior performance of guided surgery in minimizing complications and enhancing overall outcomes.

Conclusion:

Guided implant surgery demonstrated superior outcomes in terms of implant stability, reduced marginal bone loss, and higher patient satisfaction compared to conventional submerged and one-stage techniques.
Exploring the Link between Periodontal Disease and Systemic Conditions: Implications for Alzheimer’s, Parkinson’s, and Rheumatoid Arthritis
Authors: Kanimozhi  , Aishwarya K. , Yadav Sweta , Chandy Ajith A. , Muralikrishna Ramyashri , Shinkre Rohan
Published: November 2024

ABSTRACT

Background:

There is a growing correlation between periodontal disease, a common inflammatory disorder that affects the tissues supporting the teeth, and several systemic diseases.

Materials and Methods:

Two hundred patients from a tertiary care hospital, ages 50–75, participated in this cross-sectional research. The subjects were split up into four groups: 50 individuals with rheumatoid arthritis, 50 with Alzheimer’s disease, 50 with Parkinson’s disease, and 50 with periodontal disease. To evaluate periodontal condition, including clinical attachment loss and pocket depth, thorough oral exams were performed. Measurements were made of serum biomarkers for inflammation, such as interleukin-6 (IL-6) and C-reactive protein (CRP). Multivariate regression models were used to examine correlations between the severity of periodontal disease and the underlying systemic diseases.

Results:

In all groups, there were significant relationships between higher levels of indicators of systemic inflammation and the severity of periodontal disease. In comparison to healthy controls (CRP mean value: 2.1 mg/L; IL-6 mean value: 6.4 pg/mL), participants with periodontal disease had higher mean levels of CRP (5.6 mg/L) and IL-6 (mean value: 12.8 pg/mL). Furthermore, compared to those with rheumatoid arthritis, those with Alzheimer’s and Parkinson’s disorders showed higher levels of pocket depth and periodontal attachment loss.

Conclusion:

In conclusion, the results point to a possible connection between systemic diseases such rheumatoid arthritis, Parkinson’s disease, and Alzheimer’s.
Climatic and ecological factors responsible for distribution of Phlebotomine Sand flies and occurrence of Cutaneous Leishmaniasis, in Himachal Pradesh India
Authors: Lata Suman , Kumar Gaurav , Bhakuni Bharat , Kumari Sandhya , Dhiman Ramesh C
Published: November 2024

Background & objectives:

Subalpine valley along the Sutlej River has been identified as an endemic focus for Cutaneous Leishmaniasis (CL) in Himachal Pradesh (H.P.). The present study was undertaken with aim to find out the climatic and ecological determinants responsible for distribution of sand flies and occurrence of Cutaneous Leishmaniasis in Himachal Pradesh.

Methods:

Collections of sand flies were made in the Shimla, Kullu, and Nichar districts of H.P. during 2017 and 2019. The climatic data were procured from Indian Meteorological centre, Shimla (H.P). The satellite images (Indian remote sensing satellite (IRS)-Linear imaging self-scanner (LISS)-IV sensor multispectral data) having resolution of 5.8m were procured from National Remote Sensing Centre Hyderabad, India. The relationship between the incidence of CL and Land use was analysed.

Results:

A total of 332 sand flies were collected. The transmission of CL was favoured by temperatures exceeding 20°C over a period of six months, specifically from April to September. The valley with an elevation ranging between 1000 to 1250 meters reported 90% of the CL cases. The correlation between CL incidence and land use patterns revealed a notable rise in barren land (8%) and scrub land (5%) from 2013 to 2017.

Interpretation & conclusion:

The findings reveals that specific meteorological conditions and land cover play significant role in determining the presence of sand flies in Himachal Pradesh. To effectively control CL, it is recommended to implement control programs primarily between June and September, focusing particularly on regions with elevations ranging from 1000 to 1250 meters.
Grafts of hydrogel-embedded electrically stimulated subventricular stem cells into the stroke cavity improves functional recovery of mice
Authors: Cercel Andreea-Mihaela , Boboc Ianis KS , Surugiu Roxana , Doeppner Thorsten R. , Hermann Dirk M. , Catalin Bogdan , Gresita Andrei , Popa-Wagner Aurel
Published: November 2024

The major aim of stroke therapy is to stimulate brain repair and improve behavioral recovery after cerebral ischemia. One option is to stimulate endogenous neurogenesis in the subventricular zone and direct the newly formed neurons to the damaged area. However, only a small percentage of these neurons survive, and many do not reach the damaged area, possibly because the corpus callosum impedes the migration of subventricular zone-derived stem cells into the lesioned cortex. A second major obstacle to stem cell therapy is the strong inflammatory reaction induced by cerebral ischemia, whereby the associated phagocytic activity of brain macrophages removes both therapeutic cells and/ or cell-based drug carriers. To address these issues, neurogenesis was electrically stimulated in the subventricular zone, followed by isolation of proliferating cells, including newly formed neurons, which were subsequently mixed with a nutritional hydrogel. This mixture was then transferred to the stroke cavity of day 14 post-stroke mice. We found that the performance of the treated animals improved in behavioral tests, including novel object, open field, hole board, grooming, and “time-to-feel” adhesive tape tests. Furthermore, immunostaining revealed that the stem cell marker nestin, the neuroepithelial marker Mash1, and the immature neuronal marker doublecortin-positive cells survived in the transplanted area for 2 weeks, possibly due to reduced phagocytic activity and supportive angiogenesis. These results clearly indicate that the transplantation of committed subventricular zone stem cells combined with a protective nutritional gel directly into the infarct cavity after the peak of stroke-induced neuroinflammation represents a feasible approach to improve neurorestoration after cerebral ischemia.
Transplantation of human neural stem cells repairs neural circuits and restores neurological function in the stroke-injured brain
Authors: Wang Peipei , Liu Peng , Ding Yingying , Zhang Guirong , Wang Nan , Sun Xiaodong , Li Mingyue , Li Mo , Bao Xinjie , Chen Xiaowei
Published: November 2024

Exogenous neural stem cell (NSC) transplantation has become one of the most promising treatment methods for chronic stroke. Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury, which limits the ability to observe long-term behavioral recovery. Here, we used a severe stroke rat model with 150 minutes of ischemia, which produced severe behavioral deficiencies that persisted at 12 weeks, to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke. Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function, reduced infarction volume, long-term human neural stem cell survival, and improved local inflammatory environment and angiogenesis. We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo, formed stable functional synaptic connections with host neurons, and exhibited the electrophysiological properties of functional mature neurons, indicating that they replaced the damaged host neurons. The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke, which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.
Overexpression of the inwardly rectifying potassium channel Kir4.1 or Kir4.1 Tyr9 Asp in Müller cells exerts neuroprotective effects in an experimental glaucoma model
Authors: Li Fang , Li Zhen , Li Shuying , Zhou Hong , Guo Yunhui , Wang Yongchen , Lei Bo , Miao Yanying , Wang Zhongfeng
Published: November 2024

Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells, which is involved in retinal ganglion cell apoptosis in glaucoma. Modulation of Kir4.1 expression in Müller cells may therefore be a potential strategy for attenuating retinal ganglion cell damage in glaucoma. In this study, we identified seven predicted phosphorylation sites in Kir4.1 and constructed lentiviral expression systems expressing Kir4.1 mutated at each site to prevent phosphorylation. Following this, we treated Müller glial cells in vitro and in vivo with the mGluR I agonist DHPG to induce Kir4.1 or Kir4.1 Tyr9Asp overexpression. We found that both Kir4.1 and Kir4.1 Tyr9Asp overexpression inhibited activation of Müller glial cells. Subsequently, we established a rat model of chronic ocular hypertension by injecting microbeads into the anterior chamber and overexpressed Kir4.1 or Kir4.1 Tyr9Asp in the eye, and observed similar results in Müller cells in vivo as those seen in vitro. Both Kir4.1 and Kir4.1 Tyr9Asp overexpression inhibited Müller cell activation, regulated the balance of Bax/Bcl-2, and reduced the mRNA and protein levels of pro-inflammatory factors, including interleukin-1β and tumor necrosis factor-α. Furthermore, we investigated the regulatory effects of Kir4.1 and Kir4.1 Tyr9Asp overexpression on the release of pro-inflammatory factors in a co-culture system of Müller glial cells and microglia. In this co-culture system, we observed elevated adenosine triphosphate concentrations in activated Müller cells, increased levels of translocator protein (a marker of microglial activation), and elevated interleukin-1β mRNA and protein levels in microglia induced by activated Müller cells. These changes could be reversed by Kir4.1 and Kir4.1 Tyr9Asp overexpression in Müller cells. Kir4.1 overexpression, but not Kir4.1 Tyr9Asp overexpression, reduced the number of proliferative and migratory microglia induced by activated Müller cells. Collectively, these results suggest that the tyrosine residue at position nine in Kir4.1 may serve as a functional modulation site in the retina in an experimental model of glaucoma. Kir4.1 and Kir4.1 Tyr9Asp overexpression attenuated Müller cell activation, reduced ATP/P2X receptor-mediated interactions between glial cells, inhibited microglial activation, and decreased the synthesis and release of pro-inflammatory factors, consequently ameliorating retinal ganglion cell apoptosis in glaucoma.
Effectiveness of a tertiary specialist obsessive–compulsive disorder (OCD) service in improving clinical outcomes for patients with treatment-resistant/complex OCD
Authors: Pilunthanakul Thanita , Yim Jackki , Jayaraman Hariram , Lau Boon Jia , Ang Desmond , Wong Sheena , Gupta Bhanu
Published: November 2024

Introduction:

Obsessive-compulsive disorder (OCD) is a chronic condition that can result in significant distress and impaired quality of life (QoL). This retrospective cohort study investigated the effectiveness of individually tailored pharmacotherapy, exposure and response prevention (ERP), and socioeconomic and family interventions on clinical outcomes at a specialist clinic focused on treatment-resistant/complex OCD.

Methods:

Patients with treatment-resistant/complex OCD treated at the Institute of Mental Health OCD clinic, Singapore, between January 2015 and March 2019 were invited to participate in the study. The interventions included pharmacotherapy and 12–60 intensive cognitive behavioural therapy/ERP sessions, and targeted socio-occupational dysfunction and family accommodation. Yale–Brown obsessive–compulsive scale (Y-BOCS) and Quality-of-Life Enjoyment and Satisfaction Questionnaire Short Form (Q-LES-Q-SF) scales were administered pre- and post-treatment. Linear regression and one-way analysis of variance were used for data analysis.

Results:

Overall, there was a significant reduction in Y-BOCS score of 9.2 (P < 0.001) and an improvement in Q-LES-Q-SF score of 11.6 (P < 0.001). Of 70 participants, 35 (50%), 12 (17%), and 23 (33%) achieved full, partial, and no treatment response, respectively. Improvement in OCD symptoms was associated with lower baseline Y-BOCS scores and being married. Improvement in QoL was associated with higher baseline Q-LES-Q-SF scores.

Conclusion:

Interventions at the clinic improved OCD symptoms and QoL in patients with treatment-resistant/complex OCD, likely due to the simultaneous socio-occupational support services available.
Cytotoxic Drug Wastage Resulting during the Treatment of Head and Neck Cancers: The First Study Addressing the Quantity and Economic Implications
Authors: D’Souza Veena Reshma , Krishna Abhishek , Simon Paul , George Thomas , Palatty Princy Louis , Baliga Manjeshwar Shrinath
Published: November 2024

Background:

In the treatment of head and neck cancer (HNC), because the therapeutic index is narrow and the cytotoxic drug amount to be administered needs to be accurate and varies from person to person, a substantial amount of medicine can end up as leftover. This study analyzed this aspect from a financial viewpoint.

Materials and Methods:

This study recorded the prescribed dose, the chemotherapy regimens employed, the quantity utilized, and the leftover waste from the nurse’s log book, whereas the cost of the drugs was noted from the pharmacy bill and the inventory. The total and average drug costs were calculated based on each person’s actual drug wastage and pharmacy bill.

Results:

The results of the study revealed that a total of 120 HNC patients received treatment during the study period. Cisplatin, carboplatin, docetaxel, paclitaxel, and 5-fluorouracil were utilized to treat HNC and wasted medications totaled 14850 mg and accounted for 12% of reconstituted medications. Cisplatin, carboplatin, 5-fluorouracil, paclitaxel, and docetaxel had 3.15%, 14.53%, 16.675, 9.56%, and 15.10% wastage. The drug waste cost Rs. 254,421 and docetaxel had the highest wastage cost (Rs. 119,875) and cisplatin the lowest (Rs. 6414.47). Among the combination regimens, paclitaxel–carboplatin had the largest medication wastage of 425 ± 311 and 147.5 ± 101.9 mg, respectively.

Conclusion:

The results of this first-of-its-kind study on drug waste in HNC treatment indicate that the unnecessary disposal of valuable anticancer medications resulted in substantial financial losses. Efforts should be made to reduce waste and save money without risking the safety of patients by altering the treatment plans or the dosing schedules.