bluuebunny/crossref_metadata_2025 huggingface dataset:
Studi Potensi Interaksi Antibiotik Dengan Obat Lain Pada Peresepan Pasien Pneumonia Di Intensive Care Unit
Authors: Farida Yeni
Published: May 2022

Pneumonia adalah salah satu infeksi saluran nafas bawah akut yang banyak menyebabkan morbiditas dan mortalitas. Antibiotik merupakan terapi utama yang digunakan pada kasus infeksi bakteri. Penggunaan bersamaan dengan obat lain memungkinkan terjadinya interaksi yang merugikan. Penelitian ini bertujuan untuk mengetahui antibiotik yang berpotensi interaksi obat dan pengaruhnya terhadap kondisi pasien berdasarkan data klinis maupun laboratorium.

Penelitian deskriptif non eksperimental dilakukan dengan pendekatan pengambilan data secara retrospektif di ICU, NICU dan PICU. Data diperoleh dari rekam medik pasien pneumonia tahun 2016 yang memenuhi kriteria yaitu pasien yang didiagnosis pneumonia dengan penyakit penyerta, mendapatkan terapi antibiotik minimal 3 hari, dan memiliki data kultur bakteri. Interaksi obat dianalisis menggunakan Stockley’s Drug Interaction, Drug Interaction Fact, dan Medscape lalu dihitung persentase potensi interkasi, fase dan signifikansi interaksinya. 

Hasil penelitian menunjukkan bahwa diantara 28 pasien terdapat 17 jenis obat yang berpotensi menyebabkan interaksi obat pada pasien pneumonia berdasarkan literatur. Persentase interaksi obat pada fase farmakokinetika 80% dan farmakodinamika 20%. Potensi interaksi obat fase farmakokinetik terbagi menjadi 2 fase yaitu metabolisme 44%; ekskresi 36%. Signifikasi interaksi obat yaitu mayor (10%), moderate (80%) dan minor  (10%). Sebagian besar obat berpotensi berinteraksi pada fase metabolisme dengan signifikasi moderate. Potensi interaksi obat dengan persentase paling tinggi yaitu gentamycin dengan furosemide dengan signifikansi moderate sebesar 16%.
Aktivitas Analgetik dan Antiinflamasi Fraksi Daun Ashitaba (Angelica keiskei (Miq.) Koidz.) Pada Tikus Jantan Galur Wistar dan Keamanannya Terhadap Lambung
Authors: ROCHMA EKA NDHARI
Published: May 2022

Ashitaba (Angelica keiskei (Miq.) Koidz.) merupakan salah satu tanaman yang memiliki aktivitas sebagai analgetik dan antiinflamasi. Kandungan senyawa yang diduga berkhasiat adalah flavonoid, saponin, alkaloid, dan tanin. Tujuan dari penelitian ini adalah mengetahui ekstrak dan fraksi memiliki aktivitas analgetik dengan metode hot plate dan tail flick, aktivitas antiinflamasi dengan metode randall-selitto dan pembentukan udema, keamanan terhadap lambung serta mengetahui fraksi yang memberikan aktivitas paling kuat dan aman terhadap lambung tikus.

Ekstrak etanol daun ashitaba difraksinasi dengan pelarut n-heksan, etil asetat, dan air. Uji analgetik dilakukan dengan metode hot plate dan tail flick, uji antiinflamasi dilakukan dengan metode randall-selitto dan pembentukan udema kemudian dilakukan pengamatan keamanan lambung tikus secara makroskopis dan mikroskopis. Dosis ekstrak dan fraksi daun ashitaba berturut-turut yaitu ekstrak 300mg/kgBB, fraksi n-heksan 120,7mg/kgBB, fraksi etil asetat 20,6mg/kgBB, fraksi air 158,65mg/kgBB, kontrol negatif Na CMC 1%, dan asam mefenamat 500mg/kgBB.

Hasil penelitian menunjukkan ekstrak etanol, fraksi n-heksan, fraksi etil asetat, dan fraksi air daun ashitaba memiliki aktivitas sebagai analgetik dan antiinflamasi. Ekstrak 300mg/kgBB dan fraksi n-heksan 120,7mg/kgBB menunjukkan aktivitas analgetik dan antiinflamasi yang setara dengan asam mefenamat dan menunjukkan keamanan pada lambung setara dengan kontrol negatif.
Unmet Need: Evaluating Pell as a Lever for Equitable Dual Enrollment Participation and Outcomes
Authors: Bettinger Eric P. , Lu Amanda , Matheny Kaylee T. , Kienzl Gregory S.
Published: May 2022

Dual enrollment is an increasingly popular avenue for high school students to earn college credit. However, low-income students are underrepresented among dual enrollment participants. In this study, we use a difference-in-differences design to evaluate a unique federal pilot program that allowed high school students to access Pell Grants to fund their dual enrollment. Generally, we find a negative effect of the pilot program on dual enrollment participation, with no effect on subsequent college attendance. Our qualitative analysis suggests this initiative did not sufficiently meet students’ specific needs, required strong partnerships with high schools to ensure high school counselors informed students about the program, and involved substantial financial and administrative burden for participating institutions.
Association between Triglycerides to High-Density Lipoprotein Cholesterol Ratio and Death Risk in Diabetic Patients with New-Onset Acute Coronary Syndrome: A Retrospective Cohort Study in the Han Chinese Population
Authors: Shi Dongdong , Wang Le , Cong Hongliang
Published: May 2022

Background and Aims: The incidence of diabetes mellitus has reached an alarming level. Cardiovascular disease (CVD) is the leading cause of mortality in diabetic patients. However, the association between ratio and survival outcomes in patients with diabetes mellitus (DM) and new-onset acute coronary syndrome (ACS) remains unknown. This study aimed to assess the association between the TG/HDLC ratio and the risk of death in diabetic patients with new-onset acute coronary syndrome in the Han Chinese population. Methods: Data in this study were retrospectively collected from January 2016 to December 2016 from patients with type 2 diabetes mellitus (T2DM) and new-onset ACS in Tianjin Chest Hospital. Patients were classified according to the baseline TG/HDLC ratio. Kaplan-Meier survival curves were used to demonstrate survival outcomes. Univariate and multivariate Cox proportional risk regression analyses were used to evaluate the hazard ratios and 95% confidence intervals (CIs) for the risk of death. Subgroup analysis was used to determine the presence of any interaction. Results: In total, 152 patients died, 98 of them from heart disease. The Kaplan-Meier survival curve showed that there were no significant differences for both all-cause and cardiac mortality between Median 1 and Median 2 in log-rank test. Multivariate Cox regression analyses revealed that the adjusted hazard ratio increased significantly (p < 0.05) with increasing median TG/HDLC for not only all-cause mortality and cardiac death, but also nonfatal stroke, fatal stroke and fatal MI. The association between the TG/HDLC ratio and the risks of all-cause mortality and cardiac death in diabetic patients with new-onset ACS was similar among subgroups (p > 0.05). Conclusions: An elevated TG/HDLC ratio (TG/HDLC >1.522) is associated with an increased risk of all-cause and cardiac death risks in diabetic patients with new-onset ACS. Therefore, TG/HDLC ratio may be a beneficial parameter to evaluate the prognosis of this high-risk population.
Fabry Disease Cardiomyopathy: A Review of the Role of Cardiac Imaging from Diagnosis to Treatment
Authors: Fuertes Kenneally Laura , García-Álvarez María Isabel , Feliu Rey Eloísa , García Barrios Ana , Climent-Payá Vicente
Published: May 2022

Fabry disease is a rare X-linked inherited lysosomal storage disorder caused by the absence or reduction of alfa-galactosidase A activity in lysosomes, resulting in accumulation of glycosphingolipids in various tissues. The main organ affected is the heart, which frequently manifests as left ventricular hypertrophy and can ultimately lead to cardiac fibrosis, heart failure, valve disease, cardiac conduction abnormalities and sudden cardiac death. Today we know that myocyte damage starts before these signs and symptoms are detectable on routine studies, during the designated pre-clinical phase of Fabry disease. The initiation of specific therapy for Fabry disease during the early stages of the disease has a great impact on the prognosis of these patients avoiding progression to irreversible fibrosis and preventing cardiovascular complications. Cardiac imaging has become an essential tool in the management of Fabry disease as it can help physicians suspect the disorder, diagnose patients in the early stages and improve outcomes. The recent development of novel imaging techniques makes necessary an update on the subject. This review discusses the role of multimodal imaging in the diagnosis, staging, patient selection for treatment and prognosis of Fabry disease and discusses recent advances in imaging techniques that provide new insights into the pathogenesis of the disorder and the possibility of novel treatment targets.
ILMU POLITIK
Authors: Pitriyani
Published: May 2022

Ilmu politik adalah disiplin ilmu klasik yang mempelajari tentang fenomena politik. Tujuannya adalah untuk memperdalam pemahaman manusia tentang bentuk dan sifat tindakan politik dan untuk mengembangkan alat teoritis untuk menafsirkan fenomena yang bermakna secara politik
A single nucleotide variant on chromosome 12 residing within CAND1 distinguishes patients with luminal B breast cancer (II).
Authors: Mamoor Shahan
Published: May 2022

Molecular subtypes including luminal subtypes A and B drive patient outcomes in human breast cancer but the biological basis for this is not completely understood (1-4). We mined published microarray data (5, 6) to discover in an unbiased fashion the most distinguishing genetic and transcriptional features of tumors of each breast cancer molecular subtype. We identified a single nucleotide polymorphism, rs7976686, residing within CAND1, as among the most significant genetic differences in the tumors of patients with luminal B breast cancer. In a separate cohort of patients with luminal B subtype breast cancer, we observed transcriptome-wide differential expression of a CAND1 transcript. Sequence variation in the CAND1 gene may be important in understanding differences in genetic background that favor development of luminal B subtype human breast cancer.
kelembagaan dan identitas koperasi
Authors: Aulya Winda
Published: May 2022

Koperasi merupakan bagian dari tata susunan ekonomi, hal ini berarti bahwa dalam kegiatannya koperasi turut mengambil bagian bagi tercapainya kehidupan ekonomi yang sejahtera, bagi orang-orang yang menjadi anggota perkumpulan itusendiri maupun untuk masyarakat disekitarnya.
EKSISTENSI PELAKSANAAN SUPPORT SISTEM
Authors: Wijayanto Adi
Published: May 2022

Eksistensi support system dalam kehidupan sangat perlu dibahas dari berbagai sudut pandang ditengah pandemi covid-19 akan mengalami berbagai kendala dan kesulitan. Banyak permasalahan-permasalahan yang timbul sehingga perlu solusi untuk pemecahan masalah yangdihadapi. Perlakuan terhadap potensi individu sebagai makhluk sosial merupakan salah satu bentuk yang harus dipicu dan dipacu oleh setiap orang agar bisa mengatasi permasalahan dan terlebih lagi bisa bermanfaat baik padamasa pandemic ataupun masa normal baru.Buku Eksistensi Pelaksanaan Support Sistem ini sangatlah tepat di tengah kondisi pandemi Covid-19 varian baru. Semoga tulisan ringan dengan berbagai topik yang menarik disampaikan penulis, memberi manfaat bagi para pembaca, pemangku kebijakan dan masyarakat umum secara luas sehingga dapat memberikan solusi solusi atas permasalahan yang terjadi
SISTEM MANAJEMEN OPERASIONAL PADA PERUSAHAAN MANUFAKTUR CV.KEMASINDO CEMERLANG DALAM MENINGKATKAN KUALITAS PRODUKSI
Authors: Pratiwi Diana eka , Kurniawan Rachmad Risqy
Published: May 2022

This study aims to determine the operation of the operational management system in the manufacturing company CV. Kemasindo Brilliant. Based on these objectives, the researcher used a qualitative descriptive method. In obtaining the data needed in this study by using the interview method. From the results of the research conducted, it can be concluded that, in running its business, CV Kemasindo Cemerlang has carried out its management functions in the production and operational divisions well. Based on the results of the analysis of the internal and external environment at CV Kemasindo Cemerlang, it can be concluded that the regulation of the production process refers to the Standard Operating Procedure (SOP) and working instructions as well as the large number of suppliers in obtaining good product quality. Therefore, the recommended strategy for CV. Kemasindo Cemerlang is a cost leadership strategy by reducing the selling price of products so that consumers do not easily switch to other companies. This is done by providing attractive packaging while maintaining the quality of existing products.
Essai Kaitan Pembelajaran Bahasa Indonesia dengan Lingkungan
Authors: Feronika Niken Oktri
Published: May 2022

Lingkungan memiliki peran yang sangat penting bagi kehidupan. Untuk dapat menjaga lingkungan kita membutuhkan pemahaman dan pengetahuan tentang lingkungan. Menurut Ramadhan et.al (2019) di Indonesia pendidikan lingkungan bukanlah pelajaran wajib di sekolah. Oleh karena itu, pendidikan lingkungan dapat diintegrasikan ke dalam mata pelajaran lain, salah satunya adalah pembelajaran bahasa.
UAS ILMU POLITIK NAZLATUSYIFA RISWANDA
Authors: Riswanda Nazlatusyifa
Published: May 2022

1.Mengapa kekuasaan diperlukan untuk mempengaruhi kebijakan politik. Uraikan bagaimana pendapat Anda.2.Jelaskan menurut pandangan anda tentang perkembangan Dinamika Demokrasi yang ada di Indonesia. 3.Uraikan bagaimana hubungan antara politik dengan pendidikan.4.SIlakan pilih 1 tulisan di google scholar MZA Anis Anis dan Muhammad Adhitya Hidayat Putra, kemudian kutip dan korelasikan dengan materi politik disertakan contoh konkrit!5.Sebutkan dan Jelaskan Bentuk-bentuk negara yang ada di dunia.
Investigating the Presence of Neg-First Biases in Learning and Communication
Authors: Burgess Danielle
Published: May 2022

While an apparent tendency for negative markers to appear before the verb has been observed in typology, language acquisition, and language emergence, it remains uncertain what factors may motivate such a preference. The present study uses an artificial language learning paradigm to test the existence of learning asymmetries consistent with Neg-First preferences in English speakers. The study further incorporates a dyadic interaction task to investigate proposals that the Neg-First tendency is driven by communicative factors. Results show that learners overall produced more preverbal negation than was found in the input language, consistent with a Neg-First bias. However, interaction only induced greater preverbal negation use when preverbal negation was the majority word order in the input language. This does not support the proposal that communication generally promotes a Neg-First bias, but is suggestive of greater regularization when a production bias is aligned with a bias to eliminate variability during communication.
GAGASAN DAN IDE SUPPORT SISTEM
Authors: Wijayanto Adi
Published: May 2022

Makna strategis banyak dibahas dalam buku ini. Tema yang dibidik pun juga diteropong secara komprehensif. Bahasa yang digunakan pun juga ringan dan mudah dipahami. Topik yang ditulis dalam buku ini pada akhirnya menjadi menarik dan penting untuk dibaca dan dikaji kembali di tengah dinamika ilmu pengetahuan yang begitu cepat. Pada sektor kehidupan tersebut banyak mengalami permasalahan-permasalahan yang timbul sehingga perlu solusi untuk pemecahan masalah yang dihadapi. Perlakuan terhadap potensi individu secara sosial dengan baik dan benar serta sumbangsih keilmuan merupakan salah satu bentuk yang harus dipicu dan dipacu agar bisa mengatasipermasalahan.
UAS Ilmu Politik dan PIPS Jainap
Authors: Jainap
Published: May 2022

Peristiwa Jum`at Kelabu di Banjarmasin Peristiwa ini diperingati sebagai peristiwa Jumat Kelabu, karena peristiwa ini terjadi bertepatan dengan hari Jum`at, 23 Mei 1997. Menjelang pemilu partai politik yang di antaranya adalah PPP (Partai Persatuan Pembangunan), PDI (Partai Demokrat Indonesia) dan Golkar (Golongan Karya) yang sedang menggelar sebuah kampanye. Perkampungan dilakukan selama 3 hari. Golkar mendapat jatah berkampanye pada hari jumat dan bertepatan dengan ibadah salat jumat (Soenarto, 2008:166). Sebelum terlaksananya pemilu tahun 1997, beberapa pemicu keresahan masyarakat Banjar telah muncul. Kelayakan struktural yang tercermin dalam perolehan sumber daya alam oleh kelompok tertentu menjadi semakin ketat. Anda juga dapat melihat bahwa pendirian alun-alun, pusat perbelanjaan, supermarket dan hotel menyebabkan tingginya pengangguran, kejahatan dan dampak pembangunan perkotaan. Hal ini menyebabkan ketimpangan sosial dan kecemburuan ekonomi yang terus memburuk hingga kerusuhan terjadi (Salim & Achdian, 1997: 2831).
UAS ILMU POLITIK DAN PENDIDIKAN IPS
Authors: Nurhalizah Siti
Published: May 2022

1.Mengapa kekuasaan diperlukan untuk mempengaruhi kebijakan politik. Uraikan bagaimana pendapat Anda.2.Jelaskan menurut pandangan anda tentang perkembangan Dinamika Demokrasi yang ada di Indonesia. 3.Uraikan bagaimana hubungan antara politik dengan pendidikan.4.SIlakan pilih 1 tulisan di google scholar MZA Anis Anis dan Muhammad Adhitya Hidayat Putra, kemudian kutip dan korelasikan dengan materi politik disertakan contoh konkrit!5.Sebutkan dan Jelaskan Bentuk-bentuk negara yang ada di dunia.
To trust or not to Trust? Face and voice modulation of virtual avatars
Authors: Siehl Sebastian , Kammler-Sücker Kornelius , Guldner Stella , Zohair Rabia , Janvier Yannick , Nees Frauke
Published: May 2022

Objective: This study explores the graduation of social traits in virtual characters by experimental manipulation of perceived trustworthiness with the aim to validate an existing predictive model in animated whole-body avatars.Method: We created a set of 210 animated virtual characters, for which facial features were generated according to a predictive statistical model originally developed for 2D faces. In a first online study, participants (N=34) rated mute video clips of the characters on the dimensions of trustworthiness, dominance, valence, and arousal. In a second study (N=49), vocal expressions were added to the avatars, with voice recordings manipulated on the dimension of trustworthiness by their speakers. Results: In study one, as predicted, we found a significant positive linear (t(7071)=47.67, p<.001) as well as quadratic (t(7071)=-4.76, p<.001) trend in trustworthiness ratings. We found a significant negative correlation between mean trustworthiness and arousal (=-.37, p<.001), and a positive correlation with valence (=.88, p<.001). In study two, we found a significant linear (t(4465.96)=33.91, p<.001), quadratic (t(4465.96)=-10.05, p<.001), cubic (t(4465.96)=-5.90, p<.001), quartic (t(4465.96)=4.88, p<.001) and quintic (t(4465.96)=3.20, p=.001) trend in trustworthiness ratings. Similarly to study one, we found a significant negative correlation between mean trustworthiness and arousal (=-.42, p<.001) and a positive correlation with valence (=.76, p<.001).Conclusion: We successfully showed that a multisensory graduation of social traits, originally developed for 2D stimuli, can be applied to virtually animated characters, to create a battery of animated virtual humanoid male characters. These virtual avatars have a higher ecological validity in comparison to their 2D counterparts and allow for a targeted experimental manipulation of perceived trustworthiness. The stimuli could be used for social cognition research in neurotypical and psychiatric populations.
Understanding Cultural Information Flow: A Qualitative study of a small social group
Authors: Papa Aliki , Cristea Mioara , McGuigan Nicola , Tamariz Monica
Published: May 2022

This study uses qualitative data to explore closely adoption and onward transmission. Interview data were collected in relation to housework regarding the perceived behaviour of participants’ parents, of themselves, and of their (grand)children (N=14). Observational data was also collected from the members of one of the families for triangulation purposes. Following the six-phase process of thematic analysis, we extracted three main themes: individual learning, horizontal transmission, and vertical transmission. While only few instances were categorised as ‘individual learning’, the instances of horizontal and vertical transmission were numerous, and included the transmission of dichotomous traits. Thus, we explored why some cultural variants outcompete others and how certain learning and teaching mechanisms lead to increased stability and longevity. Vertical congruence was observed during the transmission of a dichotomous cultural trait: transmitters who acquired two variants of the same trait (one horizontally and one vertically) chose to vertically transmit onward to learners – i.e., their (grand)children – the variant which they had previously acquired vertically (i.e., from their own parents or grandparents), even if they exhibited both variants themselves. Horizontal congruence was observed even in sibling-to-sibling transmission, as the transmitter (older sibling) transmitted onward to the learner (younger sibling) the cultural variants which he/she had previously acquired from a peer (even if these were in competition with vertically acquired alternatives). Finally, we discuss the effects of the mother/wife-transmitter, who can weaken the effects of the vertical-congruence effect in the case of her spouse and enhance them in the case of their children.
How Effective Are Interventions Against Misinformation?
Authors: Altay Sacha
Published: May 2022

Efforts to combat misinformation have intensified in recent years. In parallel, our scientific understanding of misinformation and of our information ecosystem has improved. Here, I propose ways to improve interventions against misinformation based on this growing body of knowledge. First, because misinformation consumption is minimal and news consumption is low, more interventions should aim at increasing the uptake of reliable information. Second, because most people distrust unreliable sources but fail to sufficiently trust reliable sources, there is more room to improve trust in reliable sources than to reduce trust in unreliable sources. Third, because misinformation is largely a symptom of deeper socio-political problems, interventions should try to address these root causes, such as by reducing partisan animosity. Fourth, because a small number of powerful individuals give misinformation most of its visibility, interventions should try to target these ‘superspreaders’. Fifth, because false information is not necessarily harmful and true information can be used in misleading ways, misleadingness should take precedence over veracity in defining misinformation. Policymakers, journalists, and researchers would benefit from considering these arguments when thinking about the problem of misinformation and how to tackle it.
Qualitative Analysis Report On How Perceptual Stimuli May Affect Young Students' Metamemory
Authors: Yang Xiaoyu , Morrow Lorna
Published: May 2022

This dissertation used focus groups as qualitative research methods to collect data and analyzed the collected data under the IPA frame to explore how individuals know about memory in their daily life. This dissertation recruited 20 young adults from different countries and regions as focus group participants through academic forums and other methods to explore 1) How do young people know about memory, and 2) What elements do young adults think may affect memory? After analyzing the collected data by interpretive phenomenological analysis (IPA), the results showed that 1) Memory is the storage of individuals' subjective interpretations of external information through perceptual stimuli. 2) Individuals' subjective interpretation of external stimuli could further affect individuals' marks and encoding of objective information, thereby affecting their meta-memory. 3) Due to the lack of a comprehensive perceptual stimulus, compared with three-dimensional education, students can acquire information from two-dimensional education online to memory is limited.
Getting to know them: The influence of familiarity on the production of singular specific they
Authors: Kramer Mathew Alex , Boland Julie , Queen Robin
Published: May 2022

While the use of they as a singular pronoun with an indefinite antecedent has been available for centuries, singular they is increasingly being used to refer to specific individuals. Here, we present two experiments investigating the factors underlying oral and written production of this newer usage. We asked participants to create narratives about different individuals of varying gender presentation. The presence of a description containing a pronoun—they, she, or he—was also varied. We examined the role of familiarity with individuals whose personal pronoun is they and with LGBTQ+ communities broadly in the production of singular they. We found that familiarity was a better predictor of variation than age or gender, two variables traditionally associated with language change. Furthermore, modeling the use of they significantly increased its production. Thus, singular specific they can be—and is—acquired both through familiarity with LGBTQ+ individuals, as well as through direct exposure to a textual prompt.
Reviewing Theoretical and Generalizable Text Network Analysis: Forma Mentis Networks in Cognitive Science
Authors: Poquet Oleksandra , Stella Massimo
Published: May 2022

Recommendations for network studies in learning analytics (LA) emphasize that network construction requires careful definitions of nodes, relationships between them, and network boundaries. Thus far, LA researchers have discussed how to operationalizeinterpersonal networks in learning settings. Analytical choices used in constructing networks of text have not been examined as much. By reviewing examples of text network analysis in LA, we demonstrate that convenience-based decisions for network construction are common, particularly when the ties in the text networks are defined as the co-occurrences of words or ideas. We argue that such an approach is limited in its potential to contribute to theory or generalize across studies. This submission presents an alternative approach to network representations of the text in learning settings, using the concept of Forma Mentis Networks (FMN). As reported in previous studies, FMNs are network representations either (1) elicited from individuals through free association tasks that capture valence or (2) constructed by analysts creating shared mental maps derived from text. FMN is a theory-based and scalable approach complementary to the existing set of tools available for the analysis of teaching and learning.
Competitive Dynamics of Physician Referrals in the Era of Accountable Care Organizations
Authors: Park Sohyun , Funk Russell , Karaca-Mandic Pinar , Zaheer Aks
Published: May 2022

Advocates of healthcare reform are hopeful that accountable care organizations (ACOs) will not only help to bend the healthcare spending curve, but also lead to better quality, through reduced care fragmentation, enhanced care coordination, and overall improved collaboration among providers. In this paper, we propose an alternative view to evaluating ACO outcomes: examining how ACOs may affect care spending and quality through changes in market structure and concentration of referrals between healthcare providers. Such a perspective promises to provide fresh insights on unpacking the extent to which ACOs have fulfilled the expectations that predicated their creation. We approach this question by creating a novel, referral-based measure of market concentration. We combine several datasets, including patient referral data, data on ACOs in the Medicare Shared Savings Program, and data on regional healthcare markets. We find a complex, contingent relationship between ACO entry and referralbased market concentration. Whereas increases in the number of ACOs is negatively associated with concentration, the percentage of local providers participating in ACOs mitigates such association, suggesting that the competitive implications of ACOs depend on the nature of ACO entry. Our results also point to market structure as an important mechanism through which ACOs affect healthcare spending. Further, while referral-based market concentration is negatively associated with healthcare spending, the negative association is mitigated by the nature of ACO entry. In addition, the association between the percentage of local providers in ACOs and healthcare spending also depends on the number of ACOs established.
Soal dan Jawaban UAS POLITIK
Authors: Hidayati Helma
Published: May 2022

Kekuasaan menjadi pusat perhatian utama dalam studi ilmu politik. Dikatakan demikian karena didasari delapan alasan. Pertama, studi politik itu boleh dikatakan berurusan dengan "pengaruh dan yang berpengaruh" atau penggunaan kekuasaan, peraturan atau wewenang.
Concentration Analysis of Pb and Cd in Water and Blood Shells (Anadara granosa) in Rupat Strait Water
Authors: Sari Lita , Nasution Syafruddin , Nedi Syahril
Published: May 2022

Water pollution occurs due to waste from various community activities that produce liquid, solid, and gas waste.  One of the wastes produced is heavy metals that are harmful to organisms and humans. The research was conducted in December 2020-March 2021 in the Waters of Rupat Strait of Riau Province. This study aims to analyze the concentration of Pb and Cd metals in water and blood shells (Anadara granosa), know the relationship of Pb and Cd metal concentrations to morphometric blood shells (A. granosa), and know the relationship of Pb and Cd metal content in water and blood shells (A.granosa). The method used in the research is the survey method. The results showed that the concentration value of heavy metals in seawater in the Rupat Strait Waters (Cd 0.11mg/L), (Pb 0.86 mg/L). Concentrations of heavy metals in blood shells (A. granosa) in rupat strait waters ranged Cd (0.04 mg/kg), Pb (0.03-0.06 mg/kg). Based on these results, pb and cd metal in the sea pair in the strait has passed the quality standard set while the Metal Pb and Cd on blood shells are still below the quality standard which means it is still safe to be consumed
“Dendeng Healthy” Olahan Vegetarian Daun Singkong oleh Mahasiswa Kukerta Desa Lipatkain Selatan
Authors: Alfaruqi Ahmad , Rahman Akmal Taufiki , Alni Azzahra Dwi , Amalia Dina Indika , Junia Ellara Dwi , Fadillah Guntur haryo Imran , Arwandi Indah Putri , Yurbi Lia , Khairani Novera Mawaddah , Pradita Tri Susan
Published: May 2022

Vegetarian adalah istilah untuk orang yang makan sayur setiap hari. Orang vegetarian tidak dianjurkan untuk mengkonsumsi berbagai jenis daging. Namun, kenikmatan dendeng sapi tetap bisa mereka rasakan dengan mengolah daun singkong menjadi dendeng dari sayuran sehat. Daun singkong (Manihot utilisssima) memiliki banyak kandungan gizi mulai dari mikro dan makro. Makronutrien dalam daun singkong antara lain karbohidrat, protein, dan serat. Zat gizi mikro yang terkandung dalam daun singkong adalah vitamin A, vitamin B1, vitamin C, fosfor, kalsium, zat besi, kalium, tembaga, seng, magnesium, dan mangan. Penderita hipertensi juga bisa mengonsumsi dendeng sehat ini karena kandungan nutrisi dalam daun singkong dapat mencegah naiknya tekanan darah tinggi. Tujuan dari penelitian ini adalah agar masyarakat mampu memahami cara membuat Dendeng Sehat. Metode dalam penelitian ini menggunakan metode observasi, penulis mengumpulkan data dengan melakukan observasi langsung pada pembuatan dendeng sehat dari daun singkong. Hasil penelitian ini menemukan bahwa daun singkong dapat diolah menjadi dendeng yang sehat dan enak tanpa mengurangi khasiat dari daun singkong tersebut
Impact of Covid-19 pandemic on Hospices (ICoH): Patient Cohort Report
Authors: MacArtney John I. , Fleming Joanna , Eccles Abi , Grimley Catherine , Wesson Helen , Mayland Catriona , Mitchell Sarah , van Langen-Datta Shalene , Driscoll Ruth , Almack Kathryn , Dale Jeremy , Tatnell Lynn , Roberts Lesley
Published: May 2022

This report describes the diversity of experiences of people with life-limiting illnesses who were supported by hospices in the West Midlands during the pandemic. It is one of four cohort reports – the others focus on carers, frontline hospice staff, and senior managers respectively – that form the evidence base for a Policy Report into the impact of Covid-19 on hospices. In these reports we address the nine key themes that were identified as potentially important in our previous collaborative knowledge synthesis (MacArtney et al., 2021) and seek to address some of the policy gaps we identified in our review of recommendations for hospice practice and policy (Langen-Datta et al., 2022). Together these outputs are the result of an Economic and Social Research Council funded study (grant number: ES/W001837/1) that is one of the first studies to contribute an in-depth exploration of hospice-based experiences of the pandemic to the growing body of knowledge about the effectiveness and effects of changes to hospice services, at regional and national levels in response to Covid-19. The aim of this report is therefore to explore experiences of those with life-limiting conditions the effects of the Covid-19 pandemic on the care and support to identify recommendations for clinical practice and healthcare policy. Drawing on these findings, this report offers recommendations for hospices and clinicians who continue to provide care and support for people with life limiting conditions during the ongoing pandemic. These recommendations will also be of interest to local commissioners who will need to work with hospices in their region to ensure people with life-limiting conditions receive the support they need, and national policymakers who will need to ensure the necessary resources and guidance are available.
Study on Time Overrun related to Construction Projects in Sri Lanka
Authors: Arulvel Yathupriyan , Widisinghe Sankha
Published: May 2022

The time overrun in construction projects is a common issue around the world and no exception in Sri Lankan construction industry. The aims are to identify the causes and their significance to the project time overrun as well as to provide suggestions for those identified causes. Totally 39 significant factors were identified as relevant to Sri Lankan construction industry through a literature survey. Then a quantitative questionnaire approach was conducted to identify the significance of factors from industry professionals (civil engineers, quantity surveyors, technical officers, supervisors & directors, and the persons with minimum qualification and experience in the construction industry) working as stakeholders such as clients, consultants, and contractors without considering the project type. The previously identified 39 factors were found to be applicable to the Sri Lankan construction industry with survey results. Through the survey, 33 responses were collected and analyzed based on the relative important index of the results. Highly weighted 15 project time overrun factors were analyzed in detail. Mainly, three factors of time overrun in construction projects were identified by ranking based on overall responses; i) contractor’s improper planning, ii) mistakes during construction by contractors, and iii) delay in preparation and approval of drawings. At the same time, social and cultural factors and disputes with surroundings or neighbours got the least significance based on ranking. The relationship between the significance of factors and relevance to the construction party (contractor, consultant) is also identified in this study. From questionnaire responses, the political influence, material theft, labor attitudes and motivation, and unexpected material cost increase than the total budget was selected for the further discussion. Finally, recommendations are provided for future development projects such as the contractor’s proper planning. As well as experienced and well knowledge professional to be appointed as a project manager by contracting firm.
IMPROVING THE BENEFITS OF SELF-REGULATION OF THE PSYCHOLOGICAL STATE OF STUDENTS-HOCKEY PLAYERS DURING THE HOUR OF PLAYING ACTIVITY
Authors: Luskan O. , Kuzmenko N. , Zhuravlov S.
Published: May 2022

The article summarizes the theoretical data and further develops the methodological foundations of self-regulation of the psychological state of hockey students. It is revealed that the conditions for improving the means of self-regulation of the psychological state of hockey students in the process of their playing activities. The peculiarities of self-regulation of the psychological state of hockey students depending on the game role, which is steadily manifested in the game activity, are determined. The results of the study allow to expand the approaches to the problem of managing the psychological state of hockey athletes in the course of their playing activities. Modern science actively uses the methods of mathematical statistics to establish the degree of objectivity and reliability of life processes and ongoing scientific research. This circumstance, to a certain extent, can be attributed to the field of sports. The activities of athletes, sports teams, and the entire field of sports are based on many indicators that require an objective analysis and then adequately made decisions.

The tasks that professional activity sets for a future specialist in the field of physical culture and sports are basically related to the analysis of the influence of random factors and require decision-making under risk, choice and uncertainty based on the possession of mathematical knowledge and skills. An important role in the structure of professional knowledge of a future coach and teacher is played by the identification, forecast, prevention of crisis situations both in the personal formation of an athlete and in the development of communications in a sports team based on metrological data, the use of stochastic analysis methods and the study of probabilistic models of real processes and phenomena.
Peculiarities of training and official activity in the context of special training of future women officers of the National Police of Ukraine
Authors: Dominyuk M.
Published: May 2022

The article examines the peculiarities of professional training and service activities of future female officers for units of the National Police of Ukraine in higher education institutions with specific training conditions of the Ministry of Internal Affairs, and how specific training conditions for cadets are related to their special training. Research methods: theoretical analysis and generalization of educational and methodical recommendations, Internet resources on research topics, documentary method, method of comparison.

It was found that the high level of physical fitness, which is a component of special training, future female officers of the National Police is closely related to the efficiency of service and success of cadets in higher education with specific training conditions of the Ministry of Internal Affairs. The results of the study indicate the need to increase the level of physical fitness of future female officers during training in higher education institutions of the Ministry of Internal Affairs of Ukraine, which will increase the level of special training of cadets, the quality of education and performance.
Sports life in Kyiv and provinces under the hetmanate of the Ukrainian state
Authors: Martsincovskiy Igor
Published: May 2022

According to the Renaissance newspaper, despite the significant economic difficulties associated with the First World War, sports life in the newly formed Ukrainian Empire in the ruins of the Russian Empire developed, continuing the traditions of previous years and gaining new prospects in its development. Under the Hetmanate, the government paid considerable attention to national education, including sports. At that time, sports associations, both Ukrainian and national minorities, functioned in Kyiv and provincial cities and towns, involving citizens in various sports. The state trained teachers in physical education. The sports movement and the development of sports in the Ukrainian state actively involved not only various social groups, especially the military, but also women who took an active part in sports clubs, competitions, children's playgrounds in the country. The material of the article partially fills the information gap in the history of the development of Ukrainian sports and the training of specialists in physical education for the Ukrainian People's Republic in the Dnieper Ukraine.
Сonditions for the introduction of physical culture and health classes with elements of basketball for older preschool children
Authors: Sotnyk O. V. , Romanova V. I. , Sotnyk Z. G.
Published: May 2022

Organizational and methodological conditions for the introduction of physical culture and health classes with elements of basketball in preschool institutions are considered. The content, forms of implementation, tasks, general structure of the annual cycle of physical culture and health-improving classes for preschool children with the use of basketball are determined. The tasks and content of the preparatory, main and final stages of the annual basketball program are indicated. The peculiarities of the structure of the lesson with elements of basketball are highlighted. The effectiveness of programs of physical culture and health classes with elements of basketball will depend on the material and technical equipment, staffing and physical condition of preschool children. The program will help to improve the level of physical health, physical fitness, improve motor skills.
Analysis of the leaders of the cycling tours of the first category of difficulty in the territory of Europe
Authors: Ban Zh. , Prudnikova M.
Published: May 2022

This article presents an analysis of the reports of the leaders of bicycle hikes of the first category of complexity. The distance, duration, month, obstacles along the planned route of bicycle trails in Ukraine, Crimea, Germany, Italy, Norway, Poland, Serbia, Turkey and Portugal are disclosed. The purpose of the work was to study and analyze the specific conditions of 24 cycling hikes of the first category of complexity in different regions of the European part in the period from 2010- 2018. Result. It was determined according to the reports of the leaders of cycling tours of the first category of complexity in the period 2010-2018 that the planned route threads are 3-5 % less than the actual after passage, month of the route affects the weight of the luggage on the bike (more 1-3 kg in the spring, autumn, winter periods), different terrain (mountains, soil, sand) route requires participants to buy quality parts (brakes, tires, fork, switches, ropes, chain, ratchet).
THE ROLE OF LANGUAGE IN NEWS DISCOURSE
Authors: Mehriban Monsumova
Published: May 2022

In the article, first of all, the concepts of fact and accurate information are disclosed that make up the text of the news. Because an event worthy of news status should be taken as fact. Otherwise, high-quality media will refuse to distribute the material. In addition, it is very important to accurately convey the fact to the public. That is, the maximum proximity of the prepared material to the event accepted as fact increases the accuracy of the information. First of all, a journalist needs to have a perception of the event, to have sufficiently comprehensive information, to correctly understand reality, to have impartiality, objectivity and a sufficient lexical and grammatical base to express his formed opinion. The article also analyzes the important points to pay attention to in the choice of words and sentences in the preparation of news material, depending on the type of media. Thus, different ways of delivering information in different media also have an impact on news materials. For example, the simplicity and clarity of words, the size, and structure of sentences are approached differently, depending on whether the real audience is a reader, listener, or viewer.
THE HISTORICAL BACKGROUND TO THE DEMOCRACY OF MODERN GEORGIA
Authors: Lili Amashukeli  , Tamar Kiknadze
Published: May 2022

Georgia was a part of a totalitarian state for 70 years, but if we look back through its history, we find out that the conceptual foundations of the Georgian statehood had been prepared by the legacy of the public figures of previous epochs. The views of different historical periods and the legacy of the public figures conditioned the vector of the development of today's Georgia and the respect for the democratic values. The article is about historical experience of Georgia which has an influence on the political life of modern country.
Prognostic Factors of Early Death in Childhood Hemophagocytic Lymphohistiocytosis: Experience From A Single Tertiary Center in Thailand
Authors: Wangwarawut Kulisara , Chavananon Shevachut , Songthawee Natsaruth , Sripornsawan Pornpun , Rajborirug Songyos , Chotsampancharoen Thirachit
Published: May 2022

Objective: To establish the clinical profile, outcomes, and risk factors of mortality in pediatric hemophagocytic lymphohistiocytosis (HLH) patients admitted to a tertiary care hospital in the south of Thailand.Material and Methods: The medical records of HLH patients aged under 15 years were retrospectively reviewed. Survival times were estimated using the Kaplan-Meier estimator. Univariate associations between covariates and survival were visualized with graphs and compared using the log-rank test. Factors with statistical significance in the univariate analysis were included in a multivariate cox regression analysis.Results: A total of 24 childhood HLH cases were identified over the 20-year study period. Central nervous system (CNS) involvement at diagnosis (hazard ratio [HR]: 7.7, 95% CI: 1.2-51.2), absolute neutrophil count (ANC) <1,000.0 cells/μL (HR: 33.3, 95% CI: 2.7-39.8) and renal insufficiency (HR: 28.2, 95% CI: 2.1-373.8) were adverse risk factors. Forty-six percent of the children survived at least 30 days after diagnosis with a median survival time of 21 days. Conclusion: CNS involvement, low ANC and renal insufficiency at diagnosis were adverse risk factors for early death in HLH children.
Exploring Turkish special education teachers’ experiences of emergency remote teaching during the COVID-19 pandemic
Authors: KUZU DEMİR Elif Buğra , ÖZBEK Ahmet Bilal , DEMİR Kadir
Published: May 2022

Individuals with special needs are highly disadvantaged during the COVID-19 quarantine days, and families and children received limited support. Learning the experiences, problems and solution suggestions of teachers who are responsible for the education of children with special needs is of great importance in determining the plans to be made to provide the necessary support. The purpose of this study is to investigate in-service special education teachers’ experiences of emergency remote teaching and to seek to understand the essence of their lived experiences during the COVID-19 pandemic. This qualitative study employs a phenomenological design. This current interpretative phenomenological study consists of 21 special education teachers that meet predetermined criteria. Semi-structured interviews were used to collect the data. Five key questions and one closing question which were created by the researchers aligned with the purpose of the study were asked to the participants. As a result of the data obtained within the scope of the study, themes emerged according to special education teachers’ experiences such as technical infrastructure, ICT literacy, required technical support, transformations in performance tracking and assessment, learning resource, problem behaviors, goals and objectives, family engagement, person being supported, type of support provided and decision about sustainability.