bluuebunny/crossref_metadata_2025 huggingface dataset:
Metformin sensitizes therapeutic agents and improves outcome in pre-clinical and clinical diffuse large B-cell lymphoma
Authors: Singh Anil R. , Gu Juan J. , Zhang Qunling , Torka Pallawi , Sundaram Suchitra , Mavis Cory , Hernandez-Ilizaliturri Francisco J.
Published: July 2020

Background

The treatment of diffuse large B-cell lymphoma (DLBCL) is limited by the development of resistance to therapy, and there is a need to develop novel therapeutic strategies for relapsed and refractory aggressive lymphoma. Metformin is an oral agent for type 2 diabetes that has been shown to decrease cancer risk and lower mortality in other types of cancer.

Methods

We performed a retrospective analysis of the RPCCC database looking at patients with DLBCL treated with front-line chemotherapy. We also performed pre-clinical studies looking at the effect of metformin on cell viability, cell number, Ki67, ATP production, apoptosis, ROS production, mitochondrial membrane potential, cell cycle, effect with chemotherapeutic agents, and rituximab. Finally, we studied mouse models to see the anti-tumor effect of metformin.

Results

Among diabetic patients, metformin use was associated with improved progression-free survival (PFS) and overall survival (OS) compared to diabetic patients not on metformin. Our pre-clinical studies showed metformin is itself capable of anti-tumor effects and causes cell cycle arrest in the G1 phase. Metformin induces apoptosis, ROS production, and increased mitochondrial membrane permeability. Metformin exhibited additive/synergistic effects when combined with traditional chemotherapy or rituximab in vitro. In vivo, metformin in combination with rituximab showed improved survival compared with rituximab monotherapy.

Conclusions

Our retrospective analysis showed that metformin with front-line chemotherapy in diabetic patients resulted in improved PFS and OS. Our pre-clinical studies demonstrate metformin has potential to re-sensitize resistant lymphoma to the chemo-immunotherapy and allow us to develop a hypothesis as to its activity in DLBCL.
Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells
Authors: Kawashima Masahiro , Bensaad Karim , Zois Christos E. , Barberis Alessandro , Bridges Esther , Wigfield Simon , Lagerholm Christoffer , Dmitriev Ruslan I. , Tokiwa Mariko , Toi Masakazu , Papkovsky Dmitri B. , Buffa Francesca M. , Harris Adrian L.
Published: July 2020

Background

Humans produce heat through non-shivering thermogenesis, a metabolic process that occurs in inducible beige adipocytes expressing uncoupling protein 1 (UCP1). UCP1 dissipates the proton gradient of the mitochondrial inner membrane and converts that energy into heat. It is unclear whether cancer cells can exhibit autonomous thermogenesis. Previously, we found that the knockdown of hypoxia-inducible fatty acid binding protein 7 (FABP7) increased reactive oxygen species (ROS) in breast cancer cells. ROS are known to induce beige adipocyte differentiation.

Methods

We investigated the association of tumor hypoxia, FABP7, and UCP1 across breast cancer patients using METABRIC and TCGA data sets. Furthermore, using a breast cancer cell line, HCC1806, we tested the effect of FABP7 knockdown on cellular physiology including thermogenesis.

Results

We found a strong mutual exclusivity of FABP7 and UCP1 expression both in METABRIC and in TCGA, indicating major metabolic phenotypic differences. FABP7 was preferentially distributed in poorly differentiated-, estrogen receptor (ER) negative tumors. In contrast, UCP1 was highly expressed in normal ducts and well-differentiated-, ER positive-, less hypoxic tumors. In the cell line-based experiments, UCP1 and its transcriptional regulators were upregulated upon FABP7 knockdown. UCP1 was induced in about 20% of cancer cells, and the effect was increased further in hypoxia. UCP1 depolarized mitochondrial membranes at the site of expression. UCP1 induction was associated with the increase in proton leak, glycolysis, and maximal respiration, mimicking the typical energy profile of beige adipocytes. Most importantly, UCP1 induction elevated cancer cell temperature associated with increased vulnerability to hypoxia and γ-irradiation.

Conclusions

We demonstrated that breast cancer cells can undergo thermogenesis through UCP1 induction. Disrupting FABP7-mediated fatty acid metabolism can unlock UCP1-mediated thermogenesis, potentially making it possible to develop therapies to target thermogenesis. Further study would be warranted to investigate the effect of rise in temperature of cancer cells on patients’ outcomes and the relationship to other metabolic pathways.
The deterioration process of limestone in the Anahita Temple of Kangavar (West Iran)
Authors: Barnoos Vahid , Oudbashi Omid , Shekofteh Atefeh
Published: July 2020

The well-known archaeological site of Anahita Temple at Kangavar is one of the most important Iranian stone monuments. It has been dated by various authors in an interval extended from Achaemenid to Sasanian Persian Empires (sixth century BCE to seventh century AD). Significant weathering has been occurred in various stone blocks used in the construction of this monument. The aim of this research is to study the deterioration process of the stone blocks used in the Temple. It includes chemical and mineralogical analysis of stones, characterization of deterioration patterns and processes, and identification of factors influenced the process. Results have been obtained by on-site and laboratory studies, including optical microscopy, petrography, X-ray fluorescence, X-ray diffraction and scanning electron microscopy coupled with energy dispersive X-ray spectroscopy methods. They showed that low-porosity limestone and dolomitic limestone have been used in the construction of the Temple, which have a compact micritic structure with variable size calcite veins (sparite) and clay veins. According to the on-site and laboratory studies, the deterioration patterns are partially similar in majority of the stone blocks and include different types of detachments as well as biological colonisations. The multianalytical results proved that the deterioration process is mainly of physical weathering type, due to structural and chemical characteristics of the limestone as well as climate factors, temperature fluctuations in particular. It turned out that limestone characteristics (including presence of clay veins as well as heterogeneity of calcitic matrix (micrite and sparite)) can affect the behaviour of stone blocks against climate factors; helping us to find reasons behind physical weathering of limestone in the cultural/historical sites and monuments.
Fast and simple selenium speciation by solid phase extraction and laser-induced breakdown spectroscopy
Authors: Lee Seon Hwa , Kwon Seul-Woo , Lee Yonghoon , Nam Sang-Ho
Published: July 2020

The chemical properties including toxicity of selenium depend on the concentration and chemical structure present in the natural environment. Inorganic selenium is more toxic than organic selenium; thus, the accurate determination of inorganic selenium in various sample has been needed. HG-AAS, HPLC-ICP-MS, and GC-MS are the current methods for the determination of inorganic selenium. However, these methods have the disadvantage of expensive equipment, complicated sample preparation, and long analysis time. LIBS coupled with ion exchange membrane was used for the determination of inorganic selenium. The detection limit of inorganic selenium by the analytical method was 11.21 mg/kg, and the recoveries of 50 and 100 mg/kg Se(VI) were 98.5 % and 101.80 %, respectively. The speciation method is cost-effective, simple, and not labor intensive for the quantitation of inorganic selenium.
Speaking up: a model of self-advocacy for STEM undergraduates with ADHD and/or specific learning disabilities
Authors: Pfeifer Mariel A. , Reiter Eve Melanie , Hendrickson McKenna , Stanton Julie Dangremond
Published: July 2020

Background

Students with disabilities are underrepresented in undergraduate science, technology, engineering, and mathematics (STEM) courses. Students with disabilities who engage in self-advocacy earn higher GPAs and are more likely to graduate from college compared to students with disabilities who do not engage in self-advocacy. We utilized Test’s conceptual framework of self-advocacy, which breaks self-advocacy into four components: knowledge of self, knowledge of rights, communication, and leadership to investigate how students with invisible disabilities practice self-advocacy in undergraduate STEM courses. Through a partnership with a disability resource center (DRC), we recruited and interviewed 25 STEM majors who received accommodations for attention-deficit/hyperactivity disorder (ADHD) and/or a specific learning disorder (SLD). Data were collected using semi-structured interviews and analyzed using content analysis.

Results

We found evidence of all components of Test’s conceptual framework of self-advocacy and operationalize each based on our participants’ experiences. We identified novel components of self-advocacy for students with ADHD/SLD in undergraduate STEM courses, including knowledge of STEM learning contexts and knowledge of accommodations and the process to obtain them, as well as, a novel self-advocacy behavior, filling gaps. Filling gaps involved participants taking action to mitigate a perceived limitation in either their formal accommodations from the DRC or a perceived limitation in the instructional practices used in a STEM course. We also identified beliefs, such as view of disability and agency, which influenced the self-advocacy of our participants. We incorporated the emergent forms of self-advocacy into Test’s conceptual framework to propose a revised model of self-advocacy for students with ADHD/SLD in undergraduate STEM courses.

Conclusions

We developed a revised conceptual model of self-advocacy for students with ADHD/SLD in undergraduate STEM courses. This conceptual model provides a foundation for researchers who wish to study self-advocacy in undergraduate STEM courses for students with ADHD/SLD in the future. It also offers insights for STEM instructors and service providers about the self-advocacy experiences of students with ADHD/SLD in undergraduate STEM courses. We propose hypotheses for additional study based on our conceptual model of self-advocacy. Implications for research and teaching are discussed.
Approaching community priorities in youth sports injury prevention research
Authors: Kerr Zachary Y. , Gildner Paula , Nedimyer Aliza K. , Chandran Avinash , Kay Melissa C. , Byrd K. Hunter , Register-Mihalik Johna K.
Published: July 2020

Background

Research in youth sports is often complex. As interest in youth sports injury prevention grows, scientists should consider community priorities beyond a specific research study.

Main text

This commentary discusses the authors’ personal experiences researching concussion prevention in middle school sports, as the overarching community faced multiple challenges. These challenges included a series of weather-related emergencies that resulted in a shift in the community’s priorities, multi-day school closures, and cancellations of sports activities and meetings. We discuss the importance of considering community priorities and providing support as scientists, colleagues, and members of the communities in which we conduct research.

Conclusion

Scientists should consider the changing circumstances and dynamics surrounding community priorities in order to help drive their research-based decisions and ensure successful and respectful applications of research based on community values and priorities.
Between fragmentation and institutionalisation: the rise of migration studies as a research field
Authors: Levy Nathan , Pisarevskaya Asya , Scholten Peter
Published: July 2020

It is clear that the field of migration studies has grown significantly over the past decades. What is less known is how this growth has taken place. This article combines bibliometric metadata with expert interviews to analyse the institutionalisation of the field in terms of self-referentiality, internationalisation, and epistemic communities. Self-referentiality in migration studies has gradually increased as the field has grown, until recently. The field has internationalised in terms of international co-authorships but has done so unevenly. Finally, we find that epistemic communities in migration studies, based largely on disciplines, increasingly refer to one another and are increasingly interdisciplinary.
Best practice for the nuclear medicine technologist in CT-based attenuation correction and calcium score for nuclear cardiology
Authors: Camoni Luca , Santos Andrea , Attard Marieclaire , Mada Marius Ovidiu , Pietrzak Agata Karolina , Rac Sonja , Rep Sebastijan , Terwinghe Christelle , Fragoso Costa Pedro ,   on behalf of the Technologist Committee of the European Association of Nuclear Medicine (EANM)
Published: July 2020

The use of hybrid systems is increasingly growing in Europe and this is progressively important for the final result of diagnostic tests. As an integral part of the hybrid imaging system, computed tomography (CT) plays a crucial role in myocardial perfusion imaging diagnostics. Throughout Europe, a variety of equipment is available and also different university curricula of the nuclear medicine technologist are observed. Hence, the Technologist Committee of the European Association of Nuclear Medicine proposes to identify, through a bibliographic review, the recommendations for best practice in computed tomography applied to attenuation correction and calcium score in myocardial perfusion imaging, which courses in the set of knowledge, skills, and competencies for nuclear medicine technologists. This document aims at providing recommendations for CT acquisition protocols and CT image optimization in nuclear cardiology.
Study protocol of a pilot study on sirolimus-coated balloon angioplasty in salvaging clotted arteriovenous graft
Authors: Tan Ru Yu , Tan Chee Wooi , Pang Suh Chien , Foo Marjorie Wai Yin , Tang Tjun Yip , Gogna Apoorva , Chong Tze Tec , Tan Chieh Suai
Published: July 2020

Background

In arteriovenous graft (AVG) for haemodialysis, the primary cause of failure is venous stenosis of the graft-vein junction from neointimal hyperplasia (NIH), resulting in thrombosis. While interventions to salvage clotted AVG are known to have high clinical success rates, long-term patency rates have been suboptimal. Drug-coated balloon (DCB) has been used to treat stenosed arteriovenous access in recent years with encouraging results but data on its effect in clotted AVG is unavailable.

Methods

This is an investigator-initiated, single-center, single-arm prospective pilot study to determine the safety and outcome of the sirolimus-coated balloon (SCB) in the salvage of thrombosed AVG. Twenty patients who undergo successful percutaneous thrombectomy will receive treatment with SCB at the graft vein junction. The patients will be followed-up for 6-months. The primary endpoint is the patency rates at 3-month while the secondary endpoints are the patency rates and the number of interventions needed to maintain patency at 6-month.

Discussion

Unremitting efforts have been made to prolong the patency of AV accesses over the years. DCB angioplasty combines mechanical and biological treatment for vascular stenosis. Sirolimus, being a cystostatic anti-proliferative agent, has been successfully used in coronary artery interventions. As the primary pathology of vascular stenosis in the dialysis circuit is neointimal hyperplasia, the use of sirolimus in balloon angioplasty may be effective. With this prospective study, we evaluate the efficacy and safety of SCB in patients with clotted AVG.

Trial registration

ClinicalTrials.gov Identifier: NCT03666208 on 11 September 2018.
Anthropometric and metabolic pattern in obese Egyptian children: its association with C-reactive protein
Authors: Mohamed Nageh S. , Maher Sheren Esam , Abozaid Samah M. M. , Moenes Hend M.
Published: July 2020

Background

Obesity is the most common chronic metabolic disease in children. The global prevalence of obesity has doubled from 1990 to 2015. Worryingly, the increase is more in children than adults. It has reached epidemic ranges and is a significant global problem. High-sensitivity C-reactive protein (hs-CRP) is a parameter that is used to assess inflammation and risk factor for cardiovascular events. Some reports describe an association between hs-CRP and obesity. The objective of the study is to evaluate anthropometric and metabolic parameters in obese Egyptian children and correlate them with hs-CRP level.

Results

For anthropometric variables, they were significantly higher in obese group than normal weight except for height (Pvalue 0.001). A significant difference was reported for all lipid profile parameters between obese and normal-weight groups (Pvalue 0.001). Also, CRP showed a positive correlation with both BMI as well as total cholesterol, while no correlation was observed with other parameters of obesity (r: 0.41, 0.29 respectively).

Conclusion

Elevated CRP may have a role in predicting altered lipid metabolism in obese children and this raises the possibility of cardiovascular diseases. Hence, preventive measures to control obesity is necessary.
Reducing childhood obesity: evaluation of an Early Years Nutrition programme in a deprived London borough
Authors: Patil Priyanka , Alexander Emma C. , Cupp Meghan , Lakhanpaul Monica , Peachey Meradin , Light Alexander , Manikam Logan
Published: July 2020

Background:Childhood obesity is a growing global health concern, with far-reaching implications on health in childhood and in later life. Early intervention strategies are key to reducing childhood obesity. This study aims to evaluate the implementation of an Early Years Nutrition programme in the London Borough of Newham’s children’s centres.

Methods:A service evaluation of the Early Years Nutrition programme was conducted at children’s centres within the borough. Information was collected on the sessions provided to parents by staff, breastfeeding promotion and nutritional topics the centres were displaying. Nutritional activities in each centre were assessed for compliance with the National Institute for Health and Care Excellence (NICE) guidelines.

Results: Eight out of eleven (72.7%) centres participated. Parent sessions focused mostly on oral health (n=4/8, 50.0%). Display board topics most commonly related to generic health and wellbeing (n=4/8, 50.0%). All centres displayed the UNICEF breastfeeding logo and complied with the NICE guidelines for nutritional activities.

Conclusions:The programme is consistent with NICE guidelines in the centres evaluated; however, further acquisition of data on obesity-associated factors specific to communities and preventive measures for reducing childhood obesity, such as increased parental and community engagement, promotion of breastfeeding and improved staff training, will help tailor similar programmes elsewhere with higher social and cultural acceptance.
ФОРМИРОВАНИЕ ВЫЧИСЛИТЕЛЬНОГО МЫШЛЕНИЯ В ПРОЦЕССЕ ОБУЧЕНИЯ СТУДЕНТОВ ВУЗА
Authors: Berman N. D.
Published: July 2020

Внедрение информационных и коммуникационных технологий изменяет все сферы жизни человека. Умение использовать возможности компьютера для решения проблем становится необходимым условием для формирования общекультурных и профессиональных компетенций студентов вуза. Рассматривается значимость развития навыков вычислительного мышления в процессе обучения студентов по дисциплине «Информатика».
ЗАКРЕПЛЕНИЕ УЧЕБНОГО МАТЕРИАЛА НА ДВУХ УРОВНЯХ УСВОЕНИЯ В ПРОЦЕССЕ ОБУЧЕНИЯ МАТЕМАТИКЕ
Authors: Kiselnikov I. V.
Published: July 2020

В статье отражены особенности организации закрепления учебного материала в процессе обучения математике в школе. Указаны условия создания положительной мотивации к обучению на уроках математики. Выделены отдельные типы заданий для закрепления учебного материала.
ИСПОЛЬЗОВАНИЕ ВЕБ-СЕРВИСОВ ДЛЯ СОЗДАНИЯ ОНЛАЙН ВИКТОРИН В ОБРАЗОВАНИИ
Authors: Korotkova M. Y.
Published: July 2020

В статье представлен обзор веб-сервисов для создания интерактивных тестов, викторин, опросов. Выявлена актуальность использования мобильных технологий и веб-сервисов. Проанализированы популярные сервисы, выявлены их отличия и сходства, выделены преимущества использования для учащихся и педагогов.
ИНТЕРАКТИВНЫЕ МЕТОДЫ ОБУЧЕНИЯ КАК СРЕДСТВО ФОРМИРОВАНИЯ ПРОФЕССИОНАЛЬНЫХ КОМПЕТЕНЦИЙ СТУДЕНТОВ ВЫСШИХ УЧЕБНЫХ ЗАВЕДЕНИЙ ПРИ ОВЛАДЕНИИ КУРСОМ «АЛГЕБРА И АНАЛИТИЧЕСКАЯ ГЕОМЕТРИЯ»
Authors: Richter T. V.
Published: July 2020

В статье выявлены интерактивные методы обучения, влияющие на формирование профессиональных компетенций студентов вузов при овладении курсом «Алгебра и аналитическая геометрия».
ФОРМИРОВАНИЕ УМЕНИЙ В ТЕХНИКЕ ВЫПУКЛОЙ ГРАВЮРЫ У УЧАЩИХСЯ ДХШ
Authors: Romanova O. A.
Published: July 2020

В данной статье рассматривается проблема недостаточного обеспечения конкретными методическими разработками по обучению выпуклой гравюры учащихся детских художественных школ. Целью является выявление особенностей техники выпуклой гравюры для определения методики формирования умений у обучаемых. В статье приведены базовые и специальные упражнения, способствующие эффективному освоению учащимися техники выпуклой гравюры.Методом проведения работы является изучение, анализ, обобщение научных источников и учебных программ дополнительного образования по рассматриваемой проблеме. Также проводятся блоки упражнений на получение знаний, умений и навыков по изучаемому разделу.Результаты работы: выполнен отбор содержания учебного материала на освоение техники выпуклой гравюры, разработаны блоки базовых и специальных упражнений для эффективного усвоения учащимися дошкольного образования названной техники.Область применения результатов: сфера дополнительного художественного образования.Предлагаемая методика по формированию умений при выполнении системы упражнений позволяет учащимся освоить приемы (упражнения) смешанной техники для упрощения процесса создания творческой работы.
COGNITIVE SPHERE DIAGNOSTICS IN VISUALLY IMPAIRED STUDENTS
Authors: Kokhan S. T. , Vinogradova N. I. , Grabovskaya Ya. I.
Published: July 2020

В своей статье авторы акцентировали внимание на необходимость выявления индивидуальных особенностей когнитивной сферы среди студентов с глубокими нарушениями зрения, являющиеся поздно-ослепшей категорией лиц. Кумуляция необходимой информации о специфики выстраивания реальной действительности в сознании слепого человека, позволяет специалистам расширять познавательные траектории возможностей у студентов данной категории при обучении в вузе.
ОСОБЕННОСТИ ЛИЧНОСТНОГО АДАПТАЦИОННОГО ПОТЕНЦИАЛА У ЛИЦ СРЕДНЕГО ВОЗРАСТА В УСЛОВИЯХ СОЦИАЛЬНОЙ ИЗОЛЯЦИИ, СОВЕРШИВШИХ ПРЕСТУПЛЕНИЕ ПРОТИВ ЛИЧНОСТИ
Authors: Bogdanova E. A. , Gubin V. A.
Published: July 2020

В статье рассматриваются теоретические и прикладные вопросы изучения адаптационного потенциала у лиц среднего возраста, находящихся в условиях социальной изоляции.
ВЛИЯНИЕ ТИПА ДЕТСКО-РОДИТЕЛЬСКИХ ОТНОШЕНИЙ НА ВОЗНИКНОВЕНИЕ СТРАХОВ В ПРОЦЕССЕ СОЦИАЛИЗАЦИИ ДЕТЕЙ СТАРШЕГО ДОШКОЛЬНОГО ВОЗРАСТА
Authors: Koltsova I. V. , Dolganina V. V.
Published: July 2020

В статье рассматриваются актуальная для современного общества проблема социализации детей, типы детско-родительских отношений и страхи детей, которые позволяют прогнозировать позитивную и негативную социализацию детей старшего дошкольного возраста. В своей работе авторы описывают влияние детско-родительских отношений на возникновение страхов у детей.
ОДАРЕННОСТЬ КАК ФАКТОР ВЫСОКИХ ЗНАЧЕНИЙ ПОКАЗАТЕЛЕЙ УЧЕБНОЙ УСПЕШНОСТИ СТУДЕНТОВ ВУЗА
Authors: Ledovskaya T. V.
Published: July 2020

В статье раскрываются понятия «способности», «одаренность», определены два основания для выделения психологических типов студентов: структурный и результативный показатель успешности учебной деятельности. Произведен анализ индивидуально-типологического состава студентов с разным типом успешности учебной деятельности и готовности к обучению.
О НЕКОТОРЫХ ХАРАКТЕРИСТИКАХ КОНФЛИКТОВ В ОРГАНИЗАЦИЯХ
Authors: Preobrazhenskiy A. P. , Choporov O. N.
Published: July 2020

В данной работе проведен анализ особенностей характеристик конфликтов, которые могут возникать в организациях. Обсуждаются возможные подходы для описания конфликтов.
ABILITY TO DIAGNOSE AS A PROFESSIONAL COMPETENCE OF A PEDAGOGUE-PSYCHOLOGIST IN THE TASKS OF COGNITIVE EFFECTIVENESS OF LEARNING SUPPORT1
Authors: Elshansky S. P. , Efimova O. S.
Published: July 2020

Цель. Целью работы было: определить уровень исследованности способности к диагностике как профессиональной компетенции педагога-психолога в различных профессиональных задачах, особенно в задачах обеспечения когнитивной эффективности обучения, показать необходимость научных исследований в обозначенной области, показать необходимость формирования диагностической компетенции педагогов-психологов в рамках университетского образования.Материалы и методы. Исследования и анализ источников проводилось по ключевым словам «диагностическая компетенция», «диагностическая способность как компетенция», «компетентностный подход»; были проанализированы стандарты высшего профессионального образования, принятые сегодня в России в сфере подготовки по направлениям «Психолого-педагогическое образование» и «Психология» для уровней «Бакалавр» и «Магистр».Результаты. Диагностическая способность однозначно является базовой профессиональной компетенцией педагога-психолога. Однако, пока еще нет точного понимания и согласия по поводу того, что именно работающий в школе специалист-психолог должен знать и уметь в отношении этой компетенции, особенно в сфере обеспечения когнитивной эффективности обучения. В статье также обсуждаются вопросы профессиональной диагностической компетенции в рамках компетентностного подхода в образовании, недостаточность исследованности и представленности диагностической компетенции в стандартах высшего профессионального образования, отношения мышления и понимания к диагностике, диагностика для обеспечения когнитивной эффективности обучения.Выводы. Сделаны выводы о том, что эффективная реализация компетентностного подхода не будет возможной без специальных исследований, нацеленных на изучение содержания, возможностей и методологии формирования профессиональных диагностических компетенций. Рассмотрение диагностики в аспектах понимания и диагностического мышления может помочь также показать необходимость профессиональных компетенций, формирование и развитие которых является задачей современного образования. Формирование диагностической компетенции сегодня находится в фокусе внимания современных ученых, однако эффективной методологии для формирования диагностических способностей пока нет.
ДУХОВНОСТЬ, ТВОРЧЕСТВО И ДУХОВНО-НРАВСТВЕННОЕ ВОСПИТАНИЕ
Authors: Zotova O. A.
Published: July 2020

Рассматриваются понятия духовность, духовно-нравственное воспитание. Анализируется влияние творчества на духовно-нравственное развитие личности.
ВОСПИТАНИЕ И ОБУЧЕНИЕ ДЕТЕЙ В ЭПОХУ НОВЫХ ТЕХНОЛОГИЙ
Authors: Nekrasova I. V.
Published: July 2020

Все это вопросы, которые нужно обсуждать. Цифровой мир уже вокруг нас, и он останется с нами. Началась новая эпоха. Перед нами стоит трудная задача: выработать принципы воспитания детей в эпоху интернета. Нам нужно все обдумать и сформулировать ряд четких правил, которые помогут в воспитании детей, а также обеспечат их безопасность и здоровье.Если хотите чему-то научить ребенка, вы должны освоить это сами. Лишь многолетний родительский опыт позволил мне понять мудрость такого подхода. Мы открываем для них мир. Поэтому мы должны сами разобраться и вникнуть, прежде чем учить своих детей.
ПРОБЛЕМЫ ИСПОЛЬЗОВАНИЯ КОМПЕТЕНТНОСТНОГО ОБУЧЕНИЯ
Authors: Preobrazhenskiy A. P. , Choporov O. N.
Published: July 2020

В данной работе проведено рассмотрение возможностей применения технологий комптентностного обучения. Приведены примеры, на что будут влиять подобные подходы.
ЭЛЕКТРОННЫЙ ТЕСТОВЫЙ МЕТОД КОНТРОЛЯ НА ЭТАПЕ ФРОНТАЛЬНОГО ОПРОСА НА УРОКАХ ИНФОРМАТИКИ У УЧАЩИХСЯ СРЕДНЕЙ ШКОЛЕ
Authors: Stolyarova I. V.
Published: July 2020

В статье рассматривается проблема современного контроля знаний в образовательных учреждениях. Представлены виды контроля, их недостатки и возможности. Особое внимание уделено фронтальному опросу, который осуществляется при помощи компьютерного тестирования.
ПРОПЕДЕВТИКА ФИЗИКИ В НАЧАЛЬНОМ КУРСЕ МАТЕМАТИКИ
Authors: Aslanyan I. V. , Toropilkina V. D.
Published: July 2020

Статья посвящена актуальной проблеме пропедевтики физики в начальном курсе математики. Рассмотрены задания, связанные с физическими понятиями и явлениями, которые можно предложить младшим школьникам с учетом характерных для них психологических особенностей.Подробно проанализированы несколько комплектов учебников математики для начальной школы на предмет отражения в них физической составляющей. Кроме этого, рассмотрены публикации по данному вопросу и на основании всего изложенного сделаны выводы, в том числе и о спиралеобразной форме пропедевтики физики в начальной школе.
Building a bond despite the trauma — the use of Multi-Family Therapy (MFT) in adoptive families
Authors: Ulasińska Roma , Lelek Agnieszka , Kozik-Merino Agnieszka , Ślęczek Katarzyna
Published: July 2020

Celem niniejszego artykułu jest prezentacja autorskiego programu, udział w którym ma poszerzać kompetencje rodziców adopcyjnych w zakresie wychowania dzieci z zaburzeniami emocjonalnymi i lękowymi i pomocy im. Kluczowym problemem, wokół którego został zbudowany program, były trudności z tworzeniem więzi w tych rodzinach . W opisywanym projekcie terapeutycznym wzięło udział 8 rodzin adopcyjnych: 15 osób dorosłych oraz 12 dzieci w wieku od 5,5–10 lat. Przygotowując projekt powoływaliśmy się na doświadczenia terapeutów stosujących metodę terapii wielorodzinnej (MFT). Dodatkowym elementem programu był wideotrening VIT. Większość uczestników pozytywnie oceniła udział w programie. Rodzice podkreślali korzyści wynikające z umożliwienia im wymiany doświadczeń, uzyskania wsparcia i zniwelowania poczucia winy. Zaangażowanie dzieci w proces terapeutyczny (MFT) pozwoliło również na poszerzenie perspektyw rozumienia ich postaw i zachowań. Tworzenie się bezpiecznej więzi w rodzinach adopcyjnych jest trudnym procesem, jednakże niezbędnym do dalszego funkcjonowania rodziny. Dlatego ważne jest, aby rodziny po adopcji mogły korzystać ze specjalistycznych oddziaływań terapeutycznych w programach ukierunkowanych na wspieranie tego procesu.
Zapiski psychoterapeuty z czasu izolacji
Authors: Maślankowski Jacek
Published: July 2020

Zapiski stanowią próbę uchwycenia w wymiarze osobistym i zawodowym, doświadczeń psychoterapeuty/superwizora w pierwszych dwóch tygodniach od ogłoszenia stanu zagrożenia epidemiologicznego. Przyjęto formę narracyjną dziennika, która pomieszcza w sobie ulotne stany emocjonalne autora i równoległe zastanowienia merytoryczne z obszaru psychoterapii. Autor zaczyna prowadzić psychoterapię indywidualną i grupową online oraz organizuje sesje superwizji grupowej również online - to wszystko w kontekście powszechnego przymusu izolacji, rodzi wyzwania wobec utrzymania settingu oraz powstrzymania pojawiających się zakłóceń w funkcji kontenerowania. Autor przygląda się jakie elementy settingu powinny zostać skorygowane a jaka część otoczenia psychoterapii powinna być kontynuowana bez naruszeń. Pojawiają się nowe elementy, które mogą utrudniać przebieg procesu ale równolegle również stanowić dodatkowy materiał interpretacyjny. Znaczącą częścią tekstu jest opis osobistego przeżycia przez psychoterapeutę stanu izolacji. Odkrywane przez terapeutę własne niewidziane miejsca lub uznane za bezpieczne nabierają nowego wymiaru i mogą uczestniczyć w przeciwprzeniesieniowych nie jasnościach. Odzyskiwanie funkcji kontenerowania zarówno w procesie psychoterapii jak i superwizji przywraca możliwość efektywnego pomagania.
Modified Langenskiöld procedure for chronic, recurrent, and congenital patellar dislocation
Authors: Ramos Omar , Burke Corey , Lewis Molly , Morrison Martin J. , Paley Dror , Nelson Scott C.
Published: July 2020

Purpose

Langenskiöld described a reconstructive soft-tissue procedure for irreducible lateral congenital patellar dislocations. Paley further detailed the technique in the surgical management of congenital femoral deficiency. The aim of this study was to evaluate the outcomes of patients with congenital, chronic and recurrent patellar dislocations treated with the modified Langenskiöld procedure.

Methods

This is a retrospective case series. Between 2011 and 2018, 18 knees in 13 patients (mean age 15.8 years (sd 4.4; 12 to 29.9), nine female) with diagnoses of recurrent (six patients, eight knees), chronic (four patients, six knees) and congenital (three patients, four knees) patellar dislocations were treated with the modified Langenskiöld procedure.

Results

There were no recurrent lateral dislocations in the congenital or recurrent groups. One of the patients in the congenital group had an overcorrection with some medial patellar maltracking but until this time has not required any further surgery. In the chronic group two of the six knees developed further dislocations; these were both on the same patient, who had no dislocations until one year after surgery. Mean Kujala score was 83.7 (sd 17; 47 to 100) for all groups. In spite of preoperative knee flexion contractures of up to 30° in three patients (six knees), all patients had full extension postoperatively. Eight patients reported being satisfied with their outcome, one was somewhat satisfied, two were very dissatisfied, and two did not respond.

Conclusion

The modified Langenskiöld reconstruction provides a powerful correction for challenging cases of congenital and recurrent patellar dislocations. Re-dislocation as well as overcorrection can occasionally occur.

Level of Evidence

Level IV
The experience of qualitative research with young fathers: considerations of gender, class and reflexive practice
Authors: Davies Laura , Hanna Esmée
Published: July 2020

Qualitative research into the lives and experiences of young fathers has seen some increased interest in recent years, yet comprehensive understandings of the ‘doing’ of such research remain absent from the literature. The small existing literature positions young men who are fathers as potentially difficult to research, in terms of access and encounters. This article draws on experiences and reflections from two UK-based research projects with young men who are fathers to explore the practice of qualitative work with this particular group of participants. Beyond the choice of methodology, there appear to be several elements pertaining to the practice of researching the lives of young men who are fathers that may require consideration. Through discussion of gender, class, context, authenticity and rapport, the article argues that researching young men is not inherently problematic but is a practice which requires consideration and substantial reflexion in order to produce fruitful research encounters for both parties. This article therefore seeks to add nuance and insight into the experience of researching with young men who are fathers, and in doing so, adds sophistication to our limited understandings of qualitative encounters with this group.
The New Left at Work
Authors: Antaya Sean
Published: July 2020

This article examines rank-and-file organizing in Windsor’s automobile factories during the 1970s. In particular, I look at the history of two organizations: Workers’ Unity and the New Tendency’s Auto Worker Group. I demonstrate how these groups were part of the North American New Left’s broader turn toward Marxism and the working class that contributed to the emergence of radical rank-and-file movements that challenged both management and bureaucratized trade union leaders. In Windsor, New Left auto workers embraced forms of autonomist Marxist politics concerned primarily with working-class self-activity at the point of production, and these activists formed connections with influential theorists and organizations in Detroit and Italy. Putting these intellectual exchanges into action, the rank-and-file organizations in Windsor used direct action in an attempt to improve working conditions and develop a radical culture of democracy on the shop floor. Although these groups were relatively short lived, their history tells us much about the trajectory of the New Left in Canada and the ways that former student activists grappled with the radical potential of 1970s working-class militancy.

 

Cet article examine l’organisation de base dans les usines automobiles de Windsor au cours des années 1970. En particulier, je prends en considération l’histoire de deux organisations: Workers’ Unity et le New Tendency’s Auto Worker Group. Je démontre comment ces groupes faisaient partie du virage plus large de la Nouvelle gauche nord-américaine vers le marxisme et la classe ouvrière qui a contribué à l’émergence de mouvements radicaux de base qui ont défié à la fois la direction et les dirigeants syndicaux bureaucratisés. À Windsor, les travailleurs de l’automobile de la Nouvelle Gauche ont adopté des formes de politique marxiste autonomiste principalement préoccupées par l’auto-activité de la classe ouvrière au point de production, et ces activistes ont établi des liens avec des organisations et théoriciens influents à Détroit et en Italie. Pour mettre ces échanges intellectuels en action, les organisations de base de Windsor ont utilisé l’action directe pour tenter d’améliorer les conditions de travail et de développer une culture radicale de la démocratie dans les ateliers. Bien que ces groupes aient été de courte durée, leur histoire nous en dit beaucoup sur la trajectoire de la Nouvelle Gauche au Canada et sur la manière dont les anciens activistes étudiants ont lutté avec le potentiel radical du militantisme ouvrier des années 1970.
Work Incentives for “Welfare Mothers” in 1970s Ontario
Authors: McKeen Wendy
Published: July 2020

This article analyzes the politics surrounding the 1970s/early 1980s introduction of work-incentive measures for “welfare mothers” in Ontario. It uses governance and assemblage theory to analyze the substance and dynamics of the debates in this area as they involved state officials, social policy and social welfare advocates, and welfare mother activists. Using a wide array of archival documents and media accounts, the article uncovers the discursive and other kinds of practices that government officials used in seeking to contain the debate and foreclose more radical possibilities, as well as the role that progressive groups sometimes played in reinforcing official expertise. The article concludes that the work incentives for welfare mothers measures were not just benign policy but mechanisms that screened out the political and, ultimately, further disempowered and marginalized welfare mothers. Such programs operate to this day to reinforce a worldview that ignores structural oppression and inequality.

 

Cet article analyse la politique entourant l’introduction des mesures d’incitation au travail pour les «mères aidantes» en Ontario dans les années 1970 et au début des années 1980. Il utilise la théorie de la gouvernance et de l’assemblage pour analyser la substance et la dynamique des débats dans ce domaine, car ils impliquaient des représentants de l’État, des défenseurs de la politique sociale et de la protection sociale et des mères activistes. À l’aide d’un large éventail de documents d’archives et de comptes rendus des médias, l’article révèle les pratiques discursives et autres que les fonctionnaires ont utilisées pour contenir le débat et exclure des possibilités plus radicales, ainsi que le rôle que les groupes progressistes ont parfois joué dans le renforcement de la compétence officielle. L’article conclut que les mesures d’incitation au travail pour les mères aidantes n’étaient pas seulement des politiques bénignes mais des mécanismes qui filtraient le politique et, en fin de compte, rendaient les mères aidantes encore plus démunies et marginalisées. De tels programmes fonctionnent à ce jour pour renforcer une vision du monde qui ignore l’oppression structurelle et l’inégalité.
Trajectories of Union Renewal
Authors: Stevens Andrew
Published: July 2020

Western Canada’s oil-exporting economies have come to rely on migrant labour as a cornerstone of economic development. A global division of labour intersecting with the constellation of Canada’s migrant worker programs has shaped the contemporary political-economic character of many Canadian provinces, including Saskatchewan. These programs have worked to construct bifurcated labour markets for growing low-wage industries that exist alongside high-wage resource-sector employment. Although a majority of these migrant workers end up employed in non-unionized workplaces, foreign workers who secure occupations in health care, construction, warehousing, and manufacturing are often represented by a union. The study explores union attitudes and union-member engagement among migrant labour through the lens of union revitalization, in an attempt to confront claims that migrant workers are without an affinity to organized labour and avoid participating in union business and the collective-bargaining process.

 

Les économies exportatrices de pétrole de l’Ouest du Canada comptent sur la main-d’œuvre migrante comme pierre angulaire du développement économique. Une division mondiale du travail qui recoupe la constellation des programmes de travailleurs migrants du Canada a façonné le caractère politico-économique contemporain de nombreuses provinces canadiennes, dont la Saskatchewan. Ces programmes ont permis de créer des marchés du travail bifurqués pour les industries à bas salaires en croissance qui coexistent avec les emplois à hauts salaires dans le secteur des ressources. Bien que la majorité de ces travailleurs migrants finissent par travailler dans des lieux de travail non syndiqués, les travailleurs étrangers qui occupent des postes dans les soins de santé, la construction, l’entreposage et la fabrication sont souvent représentés par un syndicat. L’étude explore les attitudes des syndicats et l’engagement des membres des syndicats parmi les travailleurs migrants à travers la lentille de la revitalisation syndicale, dans une tentative de confronter les affirmations selon lesquelles les travailleurs migrants n’ont aucune affinité avec le syndicalisme et évitent de participer aux affaires syndicales et au processus de négociation collective.
Exact calculation of conic constants and baffles for any two-mirror aplanatic telescope
Authors: Cordero Dávila Alberto , Rodríguez Cortés Andrea Paola , Montiel Sergio Vázquez Y
Published: July 2020

To calculate the conic constants of the primary and secondary mirrors of any aplanatic two-mirror telescope, nonexact equations have been used considering third-order approximations, although it was not considered that there is an infinite number of conic constants. In this paper, exact nonlinear equations are obtained; with them, the two conic constants of the mirrors are calculated without approximations. We also find that the conic constants depend on the position at the stop where the calculation is carried out, and there are always residual aberrations. In addition, a procedure is established for the exact calculation of the baffles. Finally, examples show the differences between exact and third-order calculations.
High-speed fiber-based spectrometer for plasma Thomson scattering
Authors: Elliott Drew B. , Gerakis Alexandros
Published: July 2020

We present a novel concept for a Thomson scattering diagnostic, based on a high-speed fiber optic spectrometer. The high-speed fiber optic spectrometer presented here translates a spectral measurement from the frequency domain into the time domain, thus requiring the use of only a single photodetector for spectral acquisition. The high temporal precision offered by the instrument gives rise to a number of advantages over traditional spectrometers, such as nearly background-free measurements and multiple uses of the same injected beam. Multiple uses of the same beam would enable greatly increased measurement rates, in the range of 10–100 MHz. The spectral range and resolution of the fiber spectrometer can be easily tailored to be optimized for the light source and experimental conditions by selecting different lengths of fiber, thus allowing for the proposed technique to exhibit high dynamic range when measuring many points simultaneously. Finally, due to the temporal separation of the background from the signal, these improvements are possible without the need for increased average input laser power.
Chaotic markers in dynamic diffraction
Authors: Magnes Jenny , Hastings Harold , Hulsey-Vincent Miranda , Congo Cheris , Raley-Susman Kathleen , Singhvi Anshul , Hatch Tyler , Szwed Erik
Published: July 2020

In a dynamic far-field diffraction experiment, we calculate the largest
Lyapunov exponent of a time series obtained from the optical
fluctuations in a dynamic diffraction pattern. The time series is used
to characterize the locomotory predictability of an oversampled
microscopic species. We use a live nematode, Caenorhabditis elegans, as a model organism to demonstrate
our method. The time series is derived from the intensity at one point
in the diffraction pattern. This single time series displays chaotic
markers in the locomotion of the Caenorhabditis
elegans by reconstructing the multidimensional phase space.
The average largest Lyapunov exponent (base e) associated with the
dynamic diffraction of 10 adult wildtype (N2) Caenorhabditis elegans is

1.27
±
0.03

s

−
1

.
Shear acoustic wave attenuation influence on acousto-optic diffraction in tellurium dioxide crystal
Authors: Mantsevich Sergey , Kostyleva Ekaterina
Published: July 2020

The slow shear acoustic wave attenuation in a tellurium dioxide crystal (

1

1
¯

0

) plane is examined. The measurements
were carried out for two crystal cutoff angles: 7° and 10.5° from the
[110] axis. The ultrasound attenuation was examined in the frequency
range of 80 to 300 MHz by the acousto-optic (AO) method. The
attenuation coefficients were determined for both acoustic wave
propagation directions for the frequency range of 200 to 300 MHz. The
influence of ultrasound attenuation on the AO cell transmission
functions was examined for the 10.5° AO cell both theoretically and
experimentally. It is shown that acoustic wave absorption affects
mainly the AO diffraction efficiency. The attenuation influence on the
AO cell transmission function shape and its half-width is not
significant.