bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional Annotation Of Hypothetical Proteins From The Bacillus Paralicheniformis Strain Bac84 Reveals Proteins with Biotechnological Potentials – an In Silico Approach
Authors: Rahman Md Atikur , Heme Uzma Habiba , Parvez Md. Anowar Khasru
Published: July 2022

A significant number of proteins in the genome of the Bacillus paralicheniformis strain Bac84 are annotated as functionally uncharacterized hypothetical proteins. Investigating these proteins' functions may help us to find novel targets for biotechnological applications. Therefore, the purpose of our research was to functionally annotate the hypothetical proteins from its genome. We employed a structured in-silico approach incorporating numerous bioinformatics tools and databases for functional annotation and characterization. Sequences of 414 hypothetical proteins were evaluated and we were able to successfully attribute a function to 37 hypothetical proteins. Moreover, we performed receiver operating characteristic analysis to assess the performance of various tools. Eight proteins were predicted with biotechnological potentials such as coenzyme A biosynthesis, phenylalanine biosynthesis, antibiotic biosynthesis, and others. Evaluation of the performance of the tools showed an accuracy of 98% which represented the rationality of the tools used. This work shows that this annotation strategy will make the functional characterization of unknown proteins easier and can find the target for further investigation.
The role of mechanosensitive TRPV4 channels in the regulation of myometrium spontaneous and oxytocin- induced contractility under normal and pathophysiologically relevant conditions
Authors: Moroz Olesia F. , Drozd Oksana O. , Lavryk Roman T. , Lazorenko Iryna O. , Zholos Alexander V.
Published: July 2022

Pharmacological modulators of TRPV4 activity were examined in the rat and human myometrial tissue as the potential drugs with the perspective of attenuation of premature uterine contractions or for strengthening them in case of their insufficiency. Changes in myometrium contractility under hypotonic stress, which often occurs in patients with preeclampsia, hypertension and diabetes and may lead to the activation of mechanosensitive TRPV4 channels were explored. Using the tissue bath system with force transducers for recording of isometric contraction of isolated human and rat pregnant myometrium strips, the amplitude of contraction, duration of contraction at 50% of maximal peak amplitude (T1/2) and integral force of contractions were measured and analyzed. Pharmacological activation of TRPV4 ion channels by its selective agonist GSK1016790A (0.3 µМ) caused an increase of the tone of human myometrium strips at term that was abolished by the TRPV4 selective antagonist HC067047 (1 µM). Under hypotonic stress the amplitude of force significantly decreased for human strips (p < 0.05) but in rat myometrium it was up to 60% higher (p < 0.05). During oxytocin-stimulated myometrium contractions TRPV4 channels were found to play the role of a limiting factor likely contributing to the reduction of excitability of uterine myocytes. We propose that the effect of activation of TRPV4 channels depends on both certain species-specific features, as well as the functional state of the myometrium. The effect of TRPV4 agonist in the presence of oxytocin opens new avenues to look for similar patterns and interactions in the regulation of uterine contractility.
Circular RNA hsa_circ_0006421 inhibits hepatocellular carcinoma by acting as a ceRNA targeting miR-134-5p/CELF2 pathway
Authors: Deng Yibin , Zhou Lv , Chen Xiaohao , Pu Junxia , Shi Junhao
Published: July 2022

Background: Hepatocellular carcinoma (HCC) has ranked sixth most common cancer in number of malignancies in the worldwide. There is plenty of evidence indicated that circular RNAs (circRNAs) exert vitally important roles in the progression of many malignancies. Nevertheless, the molecular mechanism and role of hsa_circ_0006421 in HCC are still unclear. The aim of our research is to verify the molecular mechanism and effects of hsa_circ_0006421 in HCC.Methods: First, we collected 34 paired HCC tissues and paraneoplastic tissues surgically resected from patients and analyzed the expression of hsa_circ_0006421 in HCC tissues and its relationship with clinicopathological characteristics. Then, CCK8, colony formation, cell migration assay, transwell invasion assay and Annexin-V/PI staining were used to assess the effects of hsa_circ_0006421 on the growth, migration, invasion and apoptosis of HCC cells. Next, quantitative real-time PCR (qRT-PCR) and Western blots were used to detect the expression of miR-134-5p, CELF2 and hsa_circ_0006421. In the end, the targeting interactions of miR-134-5p and hsa_circ_0006421，CELF2 and miR-134-5p were explored by the dual-luciferase reporter assay.Results: Hsa_circ_0006421 was diminished in HCC tissues and its down-regulation was related to cirrhosis history. Knocking down hsa_circ_0006421 promoted HCC cells growth, migration, invasion and inhibited apoptosis, whereas overexpressing hsa_circ_0006421 had the opposite effects. Moreover, hsa_circ_0006421 served as the competing endogenous RNA of miR-134-5p. Subsequently, there was a reciprocal relationship between CELF2 and miR-134-5p. Hsa_circ_0006421 could positively regulate the protein level of CELF2 in HCC. Conclusion: hsa_circ_0006421 inhibits liver cancer by regulating miR-134-5p/CELF2 axis.
DIGITAL FINANCIAL SERVICES AS THE MAIN PRODUCT OF FINTECH COMPANIES
Authors: Semenog A.
Published: July 2022

Despite the widespread use of the category “digital financial services” and its apparent importance in financial relations in the formation of the digital economy, the theoretical nature of digital financial services remains insufficiently disclosed and proven. In addition, the understanding of digital financial services is too narrow, given the growing trend of their use in the world as the main product of fintech companies. The article aims to analyze and compare existing approaches to understanding the essence of digital financial services and justify our own approach considering the trends caused by the activities of fintech companies in the digital economy. In this context, the paper finds that most scholars and experts view digital financial services in the context of financial inclusion and low-cost access to financial services in developing countries, identifying this category with mobile money or mobile financial services as a process of using mobile phones to access to financial services and basic financial transactions. The bibliometric analysis of scientific works devoted to studying the category “digital financial services” allowed to identify four clusters of scientific publications that identify critical features of digital financial services, characterizing them as an integral part of the digital economy. There are three groups of components: finance, the digital economy, and people’s needs. Also, the author’s definition and graphic substantiation of the essence of digital financial services are offered in work. The analysis proves that digital financial services are part of finance and fintech products of the financial sector, provided within various forms of e-commerce using current information and digital technologies to meet the needs and values of different gender components, financial security, place of residence, social status, and type of employment of different categories of people. The comparative characteristics of traditional and digital financial services are presented. Several advantages of digital financial services for meeting the needs of consumers are emphasized. It is determined that the success of digital financial services depends on the combination of digital technologies and business innovations chosen by the fintech company within a specific fintech area, which includes the areas of payments, digital banking, lending, insurance, and capital management.
Formação Continuada: Percepções Docentes sobre as Contribuições de Processos Formativos Contínuos
Authors: Braz Carlan Rodrigues Carolina , Mendonça Menezes Karla , Candito Vanessa
Published: July 2022

Este estudo analisou a percepção de docentes sobre as contribuições de processos contínuos de formação nas suas práticas pedagógicas, em uma escola estadual de Santa Maria – RS. Um grupo de pesquisadores está inserido na instituição escolar desde 2011, na qual realiza processos formativos contínuos, partindo de distintas temáticas de acordo com a demanda local. Ao analisar conjuntamente esse processo, 20 representantes do corpo docente, estiveram presentes em uma entrevista semiestruturada, que contemplou questionamentos sobre os processos formativos e suas práticas pedagógicas. Para a apreciação das repostas, utilizou-se a Análise de Conteúdo, emergindo categorias conforme a frequência do que fora exposto pelas docentes. Os resultados demonstraram mudanças substanciais nas práticas pedagógicas, pois possibilitaram a articulação do trabalho coletivo por meio da dialogicidade, interdisciplinaridade e planejamento conjunto, resultando em uma prática pedagógica reflexiva, e também um maior envolvimento dos estudantes nas propostas desenvolvidas. Sobretudo ocorreu a contextualização de situações significantes relacionadas à comunidade com os conhecimentos específicos, assim como foram abordados e trabalhados nas formações. Por fim, observou-se que o empenho do grupo de pesquisa juntamente com as docentes, favoreceu com que novas propostas e estratégias metodológicas fossem utilizadas, assim como a consolidação da relação escola-universidade ao longo dos anos.
“Cuidado, não voa tão perto do sol”: considerações para trabalhar projeto de vida com juventudes brasileiras
Authors: Pessanha Corrêa Giovanna , de Oliveira Euclides Rebeca , Colmenero Cunha Thiago
Published: July 2022

O Novo Ensino Médio institui o Projeto de Vida como obrigatório no currículo escolar, através de oficinas ou aulas onde educadores e jovens debatem sobre questões de âmbito profissional, social, físico e emocional a partir da reflexão sobre tomada de decisões e resolução de problemas. Trabalhar Projeto de Vida demanda levar em consideração as noções de possibilidades para cada indivíduo, que é singular e atravessado pelo lugar que ocupa em sociedade, e que deve ser analisado pelo docente em sua prática. A partir do alargamento dos conceitos de adolescência, juventudes e produção de subjetividade, apresenta-se  a prática da Análise do Vocacional, realizada no projeto de extensão “Construindo Um Processo De Escolhas Mesmo Quando ‘escolher’ Não É Um Verbo Disponível”, vinculado ao Instituto de Psicologia da Universidade Federal do Rio de Janeiro, como uma forma responsável de trabalhar Projeto de Vida, considerando necessariamente a pluralidade de possibilidades interseccionais e potências das juventudes, abarcando raça, classe, gênero, sexualidade, territórios, entendendo que toda vida é feita de múltiplos fatores que precisam ser escutadas pela escola contemporânea - e não tentando adequar diversas formas de ser jovem em projetos de vida irreais ou intangíveis para determinadas classes e formas de ser.
A produção científica sobre a análise do comportamento e a educação: Uma revisão sistemática de literatura
Authors: Gonçalves Arantes Gennari Ana Paula , Bazan Blanco Marília , Negrão de Araújo Roberta
Published: July 2022

Embora a Análise do Comportamento tenha se destacado em diversas áreas, vem sendo bastante criticada no âmbito educacional, entendida como reducionista e com pouca contribuição para a área. A partir do exposto, surgiu a indagação: “o que tem sido produzido em Análise do Comportamento para a Educação no Brasil?”. Logo, definiu-se como objetivo geral da presente Revisão Sistemática de Literatura: analisar os trabalhos científicos que usam os pressupostos da Análise do Comportamento voltados à Educação. Enquanto resultados, destacam-se os seguintes temas: ensino de pessoas com necessidades especiais, o ensino de leitura e Matemática, ensino de Psicologia e de Análise do Comportamento, formação de professores sob o enfoque da AC, o uso das Tecnologias Digitais e a Educação a Distância.
Harnessing the Power of Labour Law and Social Security Law to Achieve the Goal of Formalizing Labour Markets in the BRICS Countries
Authors: Guseva T. , Klepalova Ju.
Published: July 2022

The Declaration by the Labour and Employment Ministers of the BRICS countries, “Quality Jobs and Inclusive Employment Policies,” guarantees that formalization of labor markets is a global priority for the BRICS countries, as informal employment hampers productivity, potential economic growth and efforts to improve the welfare of populations worldwide. Taking into account this strategic goal, the authors analyze the informal employment processes in the BRICS countries and speculate on the transition from informal to formal employment. The article addresses the issues of inhomogeneous notional ranges used to define informal employment and recommends that the possibilities provided by labor legislation and government employment policy (such as increasing the number of formal working places and dynamic development of labor legislation directed at regulation of new employment forms) be used to tackle these issues. The potential of the social security right for achieving the goals of transition to a formal economy and social security coverage is characterized in detail; various legal forms of social security (for example, government social security, social insurance (mandatory as well as voluntary) and social support) are analyzed; and the possibilities of their application to informal workers in the BRICS countries are defined.
A IMPORTÂNCIA DA PUBLICAÇÃO DE LIVROS DE ENGENHARIA PARA A FORMAÇÃO DE NOSSOS PROFISSIONAIS
Authors: Rocha Ednardo Pereira
Published: July 2022

A educação é o principal meio de desenvolvimento social. Economia, saúde, meio ambiente, política e outros temas relevantes convergem para a educação como caminho para o avanço. Durante os primeiros anos da carreira de um docente fica bastante perceptível que o principal compromisso no trabalho não é apenas ensinar, tornando predominante a noção do papel da universidade pública no processo de transformação social.
Heat Transfer Problems with Phase Change and Their Applications
Authors: Ahmed S. G.
Published: July 2022

The present chapter mainly focuses on the definition of phase change
problems and is the entrance for both free and moving boundary problems and their
practical applications. In this chapter, we will start from the fundamentals,
definitions, and formulations; an overview of the phase change problem in both one,
two, and three dimensions is developed with physical and mathematical
formulations.
Boundary Element Methods for Heat Transfer with Phase Change Problems: Theory and Application
Authors: Ahmed S.G.
Published: July 2022

The mathematical modelling of free and moving boundary problems are an important topic in engineering, industry, technology and theoretical sciences. These models allow us to make calculations involved in phase change transitions of materials due to heat transfer. Boundary layer applications are widespread in research and industry.

Boundary Element Methods for Heat Transfer with Phase Change Problems: Theory and Application equips the reader with information about heat transfer problems occurring during phase changes. The book covers several boundary element methods, including methods for phase changes, fixed and moving domains and new approaches. The contents are rounded off with chapters on numerical results and industrial applications.

Key features:

- Simple, didactic presentation of boundary layer problems for heat transfer problems

- Covers a wide range of boundary element methods

- Includes methods for fixed and moving domains

- Explains industrial applications of the methods

- Includes solutions to numerical problems

The book serves as a textbook for students of advanced mathematics and engineering. It is also a handbook for researchers working on numerical analysis, who require a focused volume on boundary element methods for heat transfer applications.
Immunogenicity of SARS CoV-2 Vaccine
Authors: Prabha B. , Kalaiarasi G. , Keerthana B.
Published: July 2022

At present, we are in a crucial situation to find out and understand the
immune response for severe acute respiratory syndrome coronavirus inside of human
body systems. The novel coronavirus (SARS cov-2) has to cause 35 million infections
and more than 1 million deaths worldwide as on October, 2020, according to the WHO
dashboard. The explosive unfolds of SARS-CoV-2 indicate that a vaccine could be
required to cease this global pandemic. Progress in SARS-CoV-2 vaccine improvement
thus far has been faster than for some other pathogen in history. There were 42
vaccines in clinical research, and nearly 150 vaccines are in preclinical study. The
immunogenicity alone data will help to attain a goal of design and development of
good and safe vaccine averse to SARS CoV-2 infections in many countries and it also
helps to predict the efficacy of the COVID-19 vaccine. Still now, we do not have a
particular vaccine for COVID-19 infections, only we boost up our immune system to
reduce the Covid-19 infections. So, we must know about our immune systems as well
as the immunogenicity of the bio-active compounds for the prediction of the valuable
and most powerful vaccine. A vaccine against SARS CoV-2 must control the infection
and be capable of controlling the disease or transmission. For these reasons, we can
detail explaining about fundamentals and application of Immunogenicity and also
discuss its application to find out the potent SARS CoV-2-vaccine in this present study.
A study on the Chinese poetry and national enlightenment consciousness of Sofa(小坡) Oh Hyo-won(吳孝媛)during the Japanese colonial period
Authors:   The Association of DaeDong-Hanmun, Shin Doo-hwan
Published: July 2022

This thesis studies the modern enlightenment consciousness that appeared in the Chinese poem of Sofa Oh Hyo-won, a female poet who lived in Japanese colonial era. He is a female poet who was born as a woman at the end of the Joseon Dynasty and lived a strange life with a strange fate, leaving 474 poems. Most of his poems express Japanese colonial era's feminine daily life with affection, so if you look at the trajectory of life along his poems, Japanese colonial era is vividly depicted and revealed.
His poems reveal an enlightenment consciousness and advanced worldview to emphasize the need for modern women's education and establish a women's school by enlightening the Confucian feudal society of the Southern Journey to Korea. In particular, he looked back at Japanese colonial era Japan and was able to see the perception of women's education and modern civilization in poems. In addition, he moved to China, looked at the process of modernization of China, and returned after recognizing the East Asian modern era during the transition period through exchanges with Chinese celebrities. His poems written at this time have a small amount of poetry, but some poems reveal the characteristics of resistance literature, which implies nationalist literary tendencies and patriotic fighting spirit during the Japanese colonial period.
The consciousness of modern enlightenment that appears in his poems contains the awakening of the ego toward our people. The theme consciousness of his poems reveals anti-feudal, ethnic, and popular movement tendencies, and contains a spirit of desperate patriotic enlightenment aimed at excitement and education. It was only at this time that I could see the buds of true national literature and realism literature. Oh Hyo-won's Chinese poem is the Unique style of Joseon Women's History.
Moveable book untuk menanamkan karakter peduli lingkungan dan minat membaca siswa
Authors: Hidayatuloh Adil , Wangid Muhammad Nur
Published: July 2022

Penelitian ini bertujuan mengembangkan movable book berbasis pendidikan karakter yang layak dan efektif untuk menanamkan karakter peduli lingkungan dan meningkatkan minat membaca siswa. Pengumpulan data dilakukan melalui observasi, wawancara, dan angket. Validasi produk yang dikembangkan dilakukan oleh ahli bahan ajar, ahli materi, respon siswa, dan guru. Teknik analisis data menggunakan uji statistik dan uji manova. Hasil penelitian berupa movable book berbasis pendidikan karakter dinyatakan valid digunakan berdasarkan validasi ahli dan dan uji coba pada siswa.  Kevalidan pada espek bahan ajar memperoleh skor 79 dengan katagori “sangat baik”, aspek materi memperoleh skor 39 dengan kategori “sangat baik”, respon guru memperoleh skor 36 dengan kategori “sangat baik”, dan respon siswa memeperoleh skor 160 dengan kategori “baik”. Movable book yang dikembangkan efektif meningkatkan karakter penduli lingkungan dan minat membaca siswa. Hasil dari uji coba MANOVA pada data uji coba operasional menunjukan taraf signifikansi 0,002 yang berarti 0,05. Hasil ini menunjukkan bahwa terdapat perbedaan signifikan karakter peduli lingkungan dan minat membaca siswa kelas II SD.AbstractThis study aims to develop a movable book based on character education that is feasible and effective to inculcate the characters of environmental care and increase students' reading interest. This research is development research that uses a model from Borg Gall. The data collection is through observation, interviews, and questionnaires. The validation of the developed product is carried out by teaching material experts, material experts, student responses, and teachers. The data analysis used statistical tests and MANOVA test. The result of the study in the form of a movable book based on character education, which is valid based on expert validation and trials on students. The validity of the teaching material specs scored 79 with the "very good" category, the material aspect gave a score of 39, in the "very good" category, the teacher gave a score of 36, in the "very good" category, and the students gave a score of 160, in the "good" category. The developed movable book is effective in improving the students’ character of environmental care and reading interest. The results of MANOVA trials on operational trial data show a significance level of 0.002 which means 0.05. The results show that there are significant differences in the environmental care character and reading interest of grade II students.
EDUCATION FOUNDATION: HISTORY (HISTORY AS THE BASIS OF EDUCATION)
Authors: Riberu Kristianus , Rosvita Laurentia Angela
Published: July 2022

Pendidikan merupakan pengalaman belajar yang berlangsung dalam lingkungan sepanjang hidup sebagai usaha sadar yang dilakukan oleh keluarga sebagai pusat utama, masyarakat dan pemerintah melalui kegiatan bimbingan baik secara formal maupun nonformal, guna mencapai pribadi yang integral dan utuh. Sejarah telah menjadi salah satu landasan dari pendidikan di Indonesia dan dunia. Perubahan tujuan dan motif pendidikan dari masa ke masa menandakan adanya pengaruh sejarah dalam usaha menjadikan pendidikan dihari esok lebih baik lagi. Tujuan dari penelitian ini adalah mengkaji sejarah pendidikan dunia dan Indonesia serta mengetahui implikasi sejarah terhadap pendidikan. Metode penelitian ini menggunakan studi literatur. Hasil dari penelitian adalah sejarah berimplikasi pada  tujuan, proses, maupun inovasi dalam pendidikan.AbstractEducation is an experience that lasts a lifetime of a conscious effort by the family as the primary center, society, and government through tutoring activities both formal and nonformal, in order to achieve an integral and intact person. History has become one of the foundations of education in Indonesia and the world. The changes of course and motives of education overtime suggest historical influences in efforts to make tomorrow's education even better. The purpose of this study is to review the history of Indonesia and the world’s education and to know the historical implications of education. This research method using the literature study method. The result of this study is that history has implications for educational goals, processes, and innovations.
Merdeka belajar dalam pandemi: Persepsi mahasiswa terhadap pembelajaran jarak jauh berbasis mobile
Authors: Widodo Arif , Nursaptini Nursaptini
Published: July 2022

Mobile learning merupakan salah satu alternatif model pembelajaran jarak jauh (PJJ). Terlebih lagi dengan misi merdeka belajar dari pemerintah membuat mobile learning semakin dikedepankan. Hal ini tidak terlepas dari berbagai kemudahan yang ditawarkan dalam model mobile learning. Penelitian ini bertujuan untuk mendeskripsikan persepsi mahasiswa terhadap penggunaan mobile learning dalam perkuliahan. Penelitian menggunakan desain deskriptif kuantitatif. Pengumpulan data menggunakan survei. Instrumen yang digunakan berupa angket. Subjek penelitian mahasiswa PGSD Universitas Mataram. Jumlah responden yang terlibat dalam penelitian sejumlah 158 mahasiswa. Tahapan penelitian dimulai dari pembuatan instrumen, pengumpulan data, klasifikasi, tabulasi, penyajian, dan deskripsi kesimpulan. Data dianalisis dengan menggunakan statistik deskriptif. Masalah yang dikaji adalah apakah mahasiswa dapat merasakan berbagai kemudahan yang ditawarkan dalam pembelajaran berbasis mobile? Hasil survei dalam penelitian ini menunjukkan bahwa masih ada responden yang mengaku mengalami kesulitan dalam penggunaan mobile learning. Beberapa aspek kemudahan dalam pembelajaran berbasis mobile belum sepenuhnya dirasakan mahasiswa terutama terkait dengan fleksibilitas tempat dan kemudahan penguasaan materi kuliah. Dua aspek ini berkaitan erat dengan koneksi internet dan atmosfir akademik. Kemudahan yang telah dapat dirasakan adalah aspek komunikasi, informasi dan fleksibilitas waktu.AbstractMobile learning is an alternative model of distance learning (PJJ). What's more, with the government's mission to be independent of learning, mobile learning is being put forward. This is inseparable from the various conveniences offered in the mobile learning model. This study aims to describe students' perceptions regarding the use of mobile learning in lectures. The research used a quantitative descriptive design. Data collection using surveys. The instrument used was a questionnaire. The research subjects were PGSD students of Mataram University. The number of respondents involved in the study was 158 students. The research stages started with making instruments, collecting data, classifying, tabulating, presenting, and describing conclusions. Data were analyzed using descriptive statistics. The problem studied is whether students can feel the various facilities offered in mobile-based learning? The survey results in this study indicate that there are still respondents who claim to experience difficulties in using mobile learning. Some aspects of the convenience in mobile-based learning have not been fully felt by students, especially related to the flexibility of the place and the ease of mastering course material. These two aspects are closely related to the internet connection and the academic atmosphere. The ease that can be felt is the aspects of communication, information, and flexibility of time.
Cyberbullying pelajar SMA di media sosial: Prevalnsi dan rekomendasi
Authors: Efianingrum Ariefa , Dwiningrum Siti Irene Astuti , Nurhayati Riana
Published: July 2022

Di era digital saat ini, bullying ditengarai hadir di ruang online atau yang sering disebut cyberbullying. Penelitian ini mengkaji realitas cyberbullying di media sosial yang dialami pelajar SMA Indonesia. Penelitian menggunakan pendekatan kuantitatif deskriptif. Lokasi penelitian di enam wilayah di Indonesia meliputi Aceh, Medan, Jakarta, Yogyakarta, Makassar, dan Papua. Setiap wilayah diwakili 3 sekolah dengan jumlah responden 242 setiap wilayah. Responden dalam penelitian ini adalah siswa SMA semua tingkatan (kelas X, XI, dan XII) dengan jumlah total 1452 orang siswa SMA. Data penelitian bersifat kuantitatif dan dianalisis secara statistik deskriptif berupa persentase. Hasil penelitian menunjukkan bahwa cyberbullying merupakan salah satu bentuk bullying yang mulai banyak terjadi dan menunjukkan peningkatan seiring dengan semakin dominannya penggunaan media online dalam aktivitas pembelajaran maupun aktivitas sosial masyarakat. Angka cyberbullying di sekolah wilayah Indonesia yang terdiri dari daerah Aceh, Medan, Jakarta, Yogyakarta, Makassar, dan Papua berada pada kategori cukup tinggi dengan skor 69,64%. Cyberbullying merupakan keniscayaan yang terjadi di tengah saratnya penggunaan media sosial pada generasi muda. Sejumlah rekomendasi ditawarkan untuk mereduksi cyberbullying di kalangan pelajar, baik bersifat personal maupun institusional.High school student cyberbullying on social media: Prevalence and recommendations AbstractIn today's digital era, bullying occurs in the online space or what is often called cyberbullying. This study examines the reality of cyberbullying on social media experienced by Indonesian high school students. This research uses a descriptive quantitative approach. The research setting is in six regions in Indonesia include Aceh, Medan, Jakarta, Yogyakarta, Makassar, and Papua. Each region is represented with three schools by 242 respondents in each region. The Respondents in this study were high school students of all levels (class X, XI, and XII) with a number of 1452 high school students. The research data was quantitative and analyzed using descriptive statistics in the form of percentages. The results showed that cyberbullying is a form of bullying that has started to occur a lot and shows an increase in line with the increasingly dominant use of online media in learning and social activities. The cyberbullying rate in schools in the Indonesian region consisting of Aceh, Medan, Jakarta, Yogyakarta, Makassar, and Papua is at a high level, with a score of 69.64%. Cyberbullying occurs amid social media usage among the younger generation. Some recommendations are offered to reduce cyberbullying among students, both personal and institutional.
Pembelajaran ethnosciences di era revolusi industri 4.0 sebagai pemacu Higher Order Thinking Skills (HOTS)
Authors: Widyawati Ani , Dwiningrum Siti Irene Astuti , Rukiyati Rukiyati
Published: July 2022

Pembelajaran di era industri 4.0 menuntut siswa agar mampu memiliki ketrampilan berpikir kritis, kreatif, komunikatif, dan kolaboratif dalam perilaku hidup sehari-hari. Keempat kemampuan tersebut membutuhkan proses berpikir tingkat tinggi (HOTS) yang menjadi bagian dari ketrampilan abad 21. Ketrampilan abad 21 ini membutuhkan adanya proses berlatih yang teratur dengan materi yang kontekstual. Pembelajaran yang mengajak siswa belajar dari kondisi real di lingkungan dan diajak untuk mampu menyelesaikan masalah yang terjadi. Penelitian ini bersifat library research dengan metode analisis kualitatif deskriptif. Tujuan penelitian ini untuk mengupas tentang pembelajaran etnosains dalam kaitannya untuk melatihkan ketrampilan berpikir tingkkat tinggi pada peserta didik. Hasil kajian literasi diperoleh bahwa etnosains sangat sesuai diterapkan di era revolusi industri 4.0 yang harus menghasilkan pembelajaran yang bermakna dan memfasilitasi siswa untuk mengkonstruksi pengetahuan mereka dengan tetap mengkaji budaya masyarakat yang bersifat ilmiah. Etnosains dapat meningkatkan ketrampilan berpikir tingkat tinggi untuk sukses menghadapi kemajuan dunia di abad 21.Ethnoscience learning in the era IR 4.0 enhancing Higher Order Thinking Skills (HOTS)AbstractLearning in the industrial era 4.0 requires students to be able to have critical, creative, communicative, and collaborative thinking skills in their daily life behavior. These four skills are skills that require Higher-Order Thinking Processes (HOTS) which are part of 21st-century skills. These 21st-century skills require regular practice processes with contextual material. Learning that invites students to learn from real conditions in the environment and is invited to be able to solve problems that occur. This research is library research with descriptive qualitative analysis method. The research stage begins with collecting relevant scientific articles based on the proximity of the topics published in the last ten years, which will then be studied and analyzed. The purpose of this study is to explore ethnoscience learning about practicing high-level thinking skills in students. The results of the literacy study show that ethnoscience is very suitable to be applied in the era of the industrial revolution 4.0, which must produce meaningful learning and facilitate students to construct their knowledge while still studying the scientific culture of society. Ethnoscience can improve higher-order thinking skills to successfully face the progress of the world in the 21st century.
Patient-centred Communication
Authors: Kondo Kayo
Published: July 2022

This book presents a comprehensive analysis of the use of patient-/person-centred communication in providing health care for ageing populations through an ethnographic approach to physician in-home medical consultations in Tokyo, Japan, alongside interviews with physicians.
From Food to Foot: The Energy and Carbon Flows of the Human Body at Walking and Cycling
Authors:   CIRED, Ecole des Ponts ParisTech, France, Leurent Fabien
Published: July 2022

The carbon footprint of motorized transport modes per unit length traveled encompasses the unit share of the vehicle lifetime emissions, that of the transport infrastructure, and those of the motor energy, considered both from “well to tank” and from “tank to wheel”. In the active modes of transport, i.e., walking and cycling, the counterpart of motor energy is human energy, which is associated with two kinds of carbon flows: the carbon footprint of food intake, – which we call the Food to Body component – and the carbon dioxide emissions of respiration – say the Body to Foot component. In this article, we provide a model in simple mathematical form to assess those carbon flows per unit length. It involves the modal speed in (i) the Metabolic Equivalent of the Task (MET) which gives rise to the energy and carbon flows, and (ii) the ratio of time spent to length travelled. The two influences of speed onto a modal carbon footprint combine in the net MET per unit length, with some compensation. The carbon footprint of food intake varies widely depending on the food diet of individuals. In a numerical study, the Food to Foot carbon emission of walking, cycling, e-scooter riding, and driving a car are estimated and compared to the rest of modal carbon footprint. Under conditions typical of France in the 2010s based on the average food diet and low carbon intensity of electricity, the inclusion of F2F in modal footprints changes the ranking of the modes according to the carbon footprint per unit length.
The Challenges Toward Real-world Implementation of Digital Health Design Approaches: Narrative Review
Authors: Duffy Anthony , Christie Gregory J , Moreno Sylvain
Published: July 2022

Background

Digital health represents an important strategy in the future of health care delivery. Over the past decade, mobile health has accelerated the agency of health care users. Despite prevailing excitement about the potential of digital health, questions remain on efficacy, uptake, usability, and patient outcome. This challenge is confounded by 2 industries, digital and health, which have vastly different approaches to research, design, testing, and implementation. In this regard, there is a need to examine prevailing design approaches, weigh their benefits and challenges toward implementation, and recommend a path forward that synthesizes the needs of this complex stakeholder group.

Objective

In this review, we aimed to study prominent digital health intervention design approaches that mediate the digital health space. In doing so, we sought to examine the origins, perceived benefits, contrasting nuances, challenges, and typical use-case scenarios of each methodology.

Methods

A narrative review of digital health design approaches was performed between September 2020 and April 2021 by referencing keywords such as “digital health design,” “mHealth design,” “e-Health design,” “agile health,” and “agile healthcare.” The studies selected after screening were those that discussed the design and implementation of digital health design approaches. A total of 120 studies were selected for full-text review, of which 62 (51.6%) were selected for inclusion in this review.

Results

A review identifying the 5 overarching digital health design approaches was compiled: user-centered design, person-based design, human-centered design, patient-centered design, and patient-led design. The findings were synthesized in a narrative structure discussing the origins, advantages, disadvantages, challenges, and potential use-case scenarios.

Conclusions

Digital health is experiencing the growing pains of rapid expansion. Currently, numerous design approaches are being implemented to harmonize the needs of a complex stakeholder group. Whether the end user is positioned as a person, patient, or user, the challenge to synthesize the constraints and affordances of both digital design and health care, built equally around user satisfaction and clinical efficacy, remains paramount. Further research that works toward a transdisciplinarity in digital health may help break down friction in this field. Until digital health is viewed as a hybridized industry with unique requirements rather than one with competing interests, the nuances that each design approach posits will be difficult to realize in a real-world context. We encourage the collaboration of digital and health experts within hybrid design teams, through all stages of intervention design, to create a better digital health culture and design ethos.
Efficacy of Group Exercise–Based Cancer Rehabilitation Delivered via Telehealth (TeleCaRe): Protocol for a Randomized Controlled Trial
Authors: Dennett Amy M , Harding Katherine E , Peiris Casey L , Shields Nora , Barton Christian , Lynch Lauren , Parente Phillip , Lim David , Taylor Nicholas F
Published: July 2022

Background

Access to rehabilitation to support cancer survivors to exercise is poor. Group exercise–based rehabilitation may be delivered remotely, but no trials have currently evaluated their efficacy.

Objective

We aimed to evaluate the efficacy of a group exercise–based cancer rehabilitation program delivered via telehealth compared to usual care for improving the quality of life of cancer survivors.

Methods

A parallel, assessor-blinded, pragmatic randomized controlled trial with embedded cost and qualitative analysis will be completed. In total, 116 cancer survivors will be recruited from a metropolitan health network in Melbourne, Victoria, Australia. The experimental group will attend an 8-week, twice-weekly, 60-minute exercise group session supervised via videoconferencing supplemented by a web-based home exercise program and information portal. The comparison group will receive usual care including standardized exercise advice and written information. Assessments will be completed at weeks 0 (baseline), 9 (post intervention), and 26 (follow-up). The primary outcome will be health-related quality of life measured using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire at week 9. Secondary measures include walking capacity (6-minute walk test), physical activity (activPAL accelerometer), self-efficacy (Health Action Process Approach Questionnaire), and adverse events. Health service data including hospital length of stay, hospital readmissions, and emergency department presentations will be recorded. Semistructured interviews will be completed within an interpretive description framework to explore the patient experience. The primary outcome will be analyzed using linear mixed effects models. A cost-effectiveness analysis will also be performed.

Results

The trial commenced in April 2022. As of June 2022, we enrolled 14 participants.

Conclusions

This trial will inform the future implementation of cancer rehabilitation by providing important data about efficacy, safety, cost, and patient experience.

Trial Registration

Australian New Zealand Clinical Trials Registry ACTRN12621001417875; https://tinyurl.com/yc5crwtr

International Registered Report Identifier (IRRID)

PRR1-10.2196/38553
Evaluation of a Text Message–Based COVID-19 Vaccine Outreach Program Among Older Patients: Cross-sectional Study (Preprint)
Authors: Ahmed Naheed , Boxley Christian , Dixit Ram , Krevat Seth , Fong Allan , Ratwani Raj M , Wesley Deliya B
Published: July 2022

BACKGROUND

COVID-19 vaccines are vital tools in the defense against infection and serious disease due to SARS-CoV-2. There are many challenges to implementing mass vaccination campaigns for large, diverse populations from crafting vaccine promotion messages to reaching individuals in a timely and effective manner. During this unprecedented period, with COVID-19 mass vaccination campaigns essential for protecting vulnerable patient populations and attaining herd immunity, health care systems were faced with the dual challenges of vaccine outreach and distribution.

OBJECTIVE

The aim of this cross-sectional study was to assess the effectiveness of a COVID-19 vaccine text outreach approach for patients aged 65 years and older. Our goal was to determine whether this approach was successful in scheduling patients for COVID-19 vaccine appointments.

METHODS

We developed SMS text messages using the Tavoca platform. These messages informed patients of their vaccine eligibility and allowed them to indicate their interest in scheduling an appointment via a specific method (email or phone) or indicate their lack of interest in the vaccine. We tracked the status of these messages and how patients responded. Messages were sent to patients aged 65 years and older (N=30,826) at a nonprofit health care system in Washington, DC. Data were collected and examined from January 14 to May 10, 2021. Data were analyzed using multivariate multinomial and binary logistic regression models in SAS (version 9.4; SAS Institute Inc).

RESULTS

Approximately 57% of text messages were delivered to patients, but many messages received no response from patients (40%). Additionally, 42.1% (12,978/30,826) of messages were not delivered. Of the patients who expressed interest in the vaccine (2938/30,826, 9.5%), Black or African American patients preferred a phone call rather than an email for scheduling their appointment (odds ratio [OR] 1.69, 95% CI 1.29-2.21) compared to White patients. Patients aged 70-74 years were more likely to schedule an appointment (OR 1.38, 95% CI 1.01-1.89) than those aged 65-69 years, and Black or African American patients were more likely to schedule an appointment (OR 2.90, 95% CI 1.72-4.91) than White patients.

CONCLUSIONS

This study provides insights into some advantages and challenges of using a text messaging vaccine outreach for patients aged 65 years and older. Lessons learned from this vaccine campaign underscore the importance of using multiple outreach methods and sharing of patient vaccination status between health systems, along with a patient-centered approach to address vaccine hesitancy and access issues.
Efficacy of Group Exercise–Based Cancer Rehabilitation Delivered via Telehealth (TeleCaRe): Protocol for a Randomized Controlled Trial (Preprint)
Authors: Dennett Amy M , Harding Katherine E , Peiris Casey L , Shields Nora , Barton Christian , Lynch Lauren , Parente Phillip , Lim David , Taylor Nicholas F
Published: July 2022

BACKGROUND

Access to rehabilitation to support cancer survivors to exercise is poor. Group exercise–based rehabilitation may be delivered remotely, but no trials have currently evaluated their efficacy.

OBJECTIVE

We aimed to evaluate the efficacy of a group exercise–based cancer rehabilitation program delivered via telehealth compared to usual care for improving the quality of life of cancer survivors.

METHODS

A parallel, assessor-blinded, pragmatic randomized controlled trial with embedded cost and qualitative analysis will be completed. In total, 116 cancer survivors will be recruited from a metropolitan health network in Melbourne, Victoria, Australia. The experimental group will attend an 8-week, twice-weekly, 60-minute exercise group session supervised via videoconferencing supplemented by a web-based home exercise program and information portal. The comparison group will receive usual care including standardized exercise advice and written information. Assessments will be completed at weeks 0 (baseline), 9 (post intervention), and 26 (follow-up). The primary outcome will be health-related quality of life measured using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire at week 9. Secondary measures include walking capacity (6-minute walk test), physical activity (activPAL accelerometer), self-efficacy (Health Action Process Approach Questionnaire), and adverse events. Health service data including hospital length of stay, hospital readmissions, and emergency department presentations will be recorded. Semistructured interviews will be completed within an interpretive description framework to explore the patient experience. The primary outcome will be analyzed using linear mixed effects models. A cost-effectiveness analysis will also be performed.

RESULTS

The trial commenced in April 2022. As of June 2022, we enrolled 14 participants.

CONCLUSIONS

This trial will inform the future implementation of cancer rehabilitation by providing important data about efficacy, safety, cost, and patient experience.

CLINICALTRIAL

Australian New Zealand Clinical Trials Registry ACTRN12621001417875; https://tinyurl.com/yc5crwtr

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/38553
A REVIEW OF ADVANCED NANOTECHNOLOGIES AND DRUG DELIVERY SYSTEMS OF SALINOMYCIN AND THEIR ROLE IN TRIPLE-NEGATIVE BREAST CANCER
Authors: RAJ R. GOKUL , S. PREETHI , PATIL AMIT B. , JAIN VIKAS , AJMEER RAMKISHAN
Published: July 2022

Cancer cells spread to other tissues and organs when they divide incorrectly. Breast cancer (BC) is the main cause of cancer-related mortality globally. Some recent studies on cancer stem cells (CSCs), drug resistance, tumor recurrence and metastasis, and the significance of CD44+in targeted treatment for breast cancer are covered. Breast cancer stem cells (BCSCs) and bulk BC cells must be eliminated for the disease to be eliminated. Researchers have shown that Streptomyces Albus-derived monocarboxylic polyether antibiotic salinomycin kills human cancer stem cells (CSCs) and prevents the spread and growth of breast cancer cells. Several drug and apoptosis resistance mechanisms may also trigger apoptosis in breast cancer cells when salinomycin is used in combination with the treatment. Apoptosis-resistant cancer cells and cancer stem cells are both susceptible to the anticancer drug salinomycin. Salinomycin may be able to inhibit CSCs, as well as the source and structure modification of salinomycin analog exhibit potent anticancer activity, the effect of salinomycin on chemotherapeutic-resistant CSCs, and the various mechanisms by which salinomycin inhibits cancer stem cells in this study. Method and delivery technique for salinomycin Nano formulation in triple-negative breast cancer and also contains pharmacokinetics and toxicity of salinomycin. Salinomycin-based drug delivery system is the subject of the patent information. Tumor genesis, development, and invasion are all aided by salinomycin. It's possible to boost the effectiveness of cancer therapy by focusing on cancer stem cells (CSCs).