bluuebunny/crossref_metadata_2025 huggingface dataset:
A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation
Authors: Cayla Mathieu , Matthews Keith R. , Ivens Alasdair C.
Published: November 2020

Background: Low-complexity regions (LCRs) on proteins have attracted increasing attention recently due to their role in the assembly of membraneless organelles or granules by liquid-liquid phase separation. Several examples of such granules have been shown to sequester RNA and proteins in an inactive state, providing an important mechanism for dynamic post-transcriptional gene regulation. In trypanosome parasites, post-transcriptional control overwhelmingly dominates gene regulation due to the organisation of their genome into polycistronic transcription units. The purpose of the current study was to generate a substantially more comprehensive genome-wide survey of LCRs on trypanosome proteins than currently available .

Methods: Using the Shannon’s entropy method, provided in the R package ‘entropy’, we identified LCRs in the proteome of Trypanosoma brucei. Our analysis predicts LCRs and their positional enrichment in distinct protein cohorts and superimposes on this a range of post-translational modifications derived from available experimental datasets.

Results: We have identified 8162 LCRs present on 4914 proteins, representing 42% of the proteome, placing Trypanosoma brucei among the eukaryotes with the highest percentage of LCRs. Our results highlight the enrichment of LCRs in the C-terminal region of predicted nucleic acid binding proteins, these acting as favoured sites for potential phosphorylation. Phosphorylation represents 51% of the post-translational modifications present on LCRs compared to 16% on the rest of the proteome.

Conclusions: The post-translational modifications of LCRs, and in particular phosphorylation events, could contribute to post-transcriptional gene expression control and the dynamics of protein targeting to membraneless organelles in kinetoplastid parasites.
Data-Driven Optimization of Reward-Risk Ratio Measures
Authors: Ji Ran , Lejeune Miguel A.
Published: November 2020

We investigate a class of fractional distributionally robust optimization problems with uncertain probabilities. They consist in the maximization of ambiguous fractional functions representing reward-risk ratios and have a semi-infinite programming epigraphic formulation. We derive a new fully parameterized closed-form to compute a new bound on the size of the Wasserstein ambiguity ball. We design a data-driven reformulation and solution framework. The reformulation phase involves the derivation of the support function of the ambiguity set and the concave conjugate of the ratio function. We design modular bisection algorithms which enjoy the finite convergence property. This class of problems has wide applicability in finance, and we specify new ambiguous portfolio optimization models for the Sharpe and Omega ratios. The computational study shows the applicability and scalability of the framework to solve quickly large, industry-relevant-size problems, which cannot be solved in one day with state-of-the-art mixed-integer nonlinear programming (MINLP) solvers.
Gender-Sternchen, Binnen-I oder generisches Maskulinum, … (Akademische) Textstile der Personenreferenz als Registrierungen?
Authors: Kotthoff Helga
Published: November 2020

For more than 40 years, a debate on gender-related person references has been taking place in the German-speaking world. My contribution starts with a differentiation of four registers, which are currently practiced in writing and have developed specific reasoning discourses and specific social contexts of usage, as I try to show. I am going to examine these four styles of gendered person reference as “registers” in the sense of anthropological linguistics (Agha 2007). This concept of “enregisterment” implies that the producers connect themselves to a socio-symbolic cosmos and can be perceived with cultural evaluations (in production and re­ception), for example, as conservative, feminist, queer, liberal (Kotthoff 2017). Here I shall explore their (socio)linguistic underpinnings within conceptions of language ideology in order to grasp the communication-reflexive charges of these discourses.
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Authors: Krug Maximilian
Published: November 2020

Narrating is a crucial activity in theatre rehearsals. Through this activity, narratives are performed, expanded, reinterpreted, or even completely improvised. The communicative practices used by theatre professionals to develop a play as a theatrical narrative have rarely been researched, both in linguistics and theatre studies. Therefore, this paper addresses how actors, directors, and other members of a theatre production collectively develop monologues as self-contained narratives within a play. The research focuses on how narrators and listeners, as an interactional ensemble, use multimodal actions to realize such monologues. Surprisingly, the co-narrators don’t appear to imagine their future audience but construct the narrations in situ with and for the present members. This observation especially becomes evident when mobile eye-tracking glasses measure the co-narrators’ gaze behavior. It shows that members of a theatre rehearsal perform different activities (e. g., improvising, reading, prompting, instructing, discussing, monitoring) with regard to local interactional requirements. This paper illustrates the procedures with which theatre-makers produce monologues as multimodal narratives and highlights the differences that distinguish such narratives in theatre from spontaneous everyday storytellings.
Modulation format identification in fiber communications using single dynamical node-based photonic reservoir computing
Authors: Cai Qiang , Guo Ya , Li Pu , Bogris Adonis , Shore K. Alan , Zhang Yamei , Wang Yuncai
Published: November 2020

We present a simple approach based on photonic reservoir computing (P-RC) for modulation format identification (MFI) in optical fiber communications. Here an optically injected semiconductor laser with self-delay feedback is trained with the representative features from the asynchronous amplitude histograms of modulation signals. Numerical simulations are conducted for three widely used modulation formats (on–off keying, differential phase-shift keying, and quadrature amplitude modulation) for various transmission situations where the optical signal-to-noise ratio varies from 12 to 26 dB, the chromatic dispersion varies from

−
500

to 500 ps/nm, and the differential group delay varies from 0 to 20 ps. Under these situations, final simulation results demonstrate that this technique can efficiently identify all those modulation formats with an accuracy of

>
95
%

after optimizing the control parameters of the P-RC layer such as the injection strength, feedback strength, bias current, and frequency detuning. The proposed technique utilizes very simple devices and thus offers a resource-efficient alternative approach to MFI.
Spatial analysis of COVID-19 spread in Iran: Insights into geographical and structural transmission determinants at a province level
Authors: Ramírez-Aldana Ricardo , Gomez-Verjan Juan Carlos , Bello-Chavolla Omar Yaxmehen
Published: November 2020

The Islamic Republic of Iran reported its first COVID-19 cases by 19thFebruary 2020, since then it has become one of the most affected countries, with more than 73,000 cases and 4,585 deaths to this date. Spatial modeling could be used to approach an understanding of structural and sociodemographic factors that have impacted COVID-19 spread at a province-level in Iran. Therefore, in the present paper, we developed a spatial statistical approach to describe how COVID-19 cases are spatially distributed and to identify significant spatial clusters of cases and how socioeconomic and climatic features of Iranian provinces might predict the number of cases. The analyses are applied to cumulative cases of the disease from February 19thto March 18th. They correspond to obtaining maps associated with quartiles for rates of COVID-19 cases smoothed through a Bayesian technique and relative risks, the calculation of global (Moran’s I) and local indicators of spatial autocorrelation (LISA), both univariate and bivariate, to derive significant clustering, and the fit of a multivariate spatial lag model considering a set of variables potentially affecting the presence of the disease. We identified a cluster of provinces with significantly higher rates of COVID-19 cases around Tehran (p-value< 0.05), indicating that the COVID-19 spread within Iran was spatially correlated. Urbanized, highly connected provinces with older population structures and higher average temperatures were the most susceptible to present a higher number of COVID-19 cases (p-value < 0.05). Interestingly, literacy is a factor that is associated with a decrease in the number of cases (p-value < 0.05), which might be directly related to health literacy and compliance with public health measures. These features indicate that social distancing, protecting older adults, and vulnerable populations, as well as promoting health literacy, might be useful to reduce SARS-CoV-2 spread in Iran. One limitation of our analysis is that the most updated information we found concerning socioeconomic and climatic features is not for 2020, or even for a same year, so that the obtained associations should be interpreted with caution. Our approach could be applied to model COVID-19 outbreaks in other countries with similar characteristics or in case of an upturn in COVID-19 within Iran.
A decentralized framework for cultivating research lifecycle transparency
Authors: Jeng Wei , Wang Shih-Hung , Chen Hung-Wei , Huang Po-Wei , Chen Yu-Jen , Hsiao Hsu-Chun
Published: November 2020

Research transparency has been advocated as a key means of addressing the current crisis of reproducibility. This article proposes an enhanced form of research transparency, termed lifecycle transparency. Over the entire lifecycle of a research effort, this approach captures the syntactical contexts of artifacts and stakeholders, such as timestamps, agreements, and/or dependency requirements for completing each research phase. For example, such contexts might include when, where, and from whom patients’ consent and institutional review board approvals were received before a clinical trial was carried out. However, as existing open-science tools are often dedicated to certain research phases or disciplines, and thus insufficient to support lifecycle transparency, we propose a novel decentralized framework to serve as a common medium for interaction among open-science tools, and produces irrefutable and immutable proofs of progress that can be verified automatically.
Effect of long-term methylene blue treatment on the composition of mouse gut microbiome and its relationship with the cognitive abilities of mice
Authors: Gureev Artem P. , Syromyatnikov Mikhail Yu. , Ignatyeva Daria A. , Valuyskikh Valeria V. , Solodskikh Sergey A. , Panevina Anna V. , Gryaznova Maria V. , Kokina Anastasia V. , Popov Vasily N.
Published: November 2020

In recent years, methylene blue (MB) has attracted considerable interest as a potential drug for the treatment of methemoglobinemia and neurodegenerative diseases. MB is active against microorganisms from various taxonomic groups. However, no studies have yet been conducted on the effect of MB on the intestinal microbiome of model animals. The aim of this work was to study the effect of different concentrations of MB on the mouse gut microbiome and its relationship with the cognitive abilities of mice. We showed that a low MB concentration (15 mg/kg/day) did not cause significant changes in the microbiome composition. The Bacteroidetes/Firmicutes ratio decreased relative to the control on the 2nd and 3rd weeks. A slight decrease in the levels Actinobacteria was detected on the 3rd week of the experiment. Changes in the content of Delta, Gamma, and Epsilonproteobacteria have been also observed. We did not find significant alterations in the composition of intestinal microbiome, which could be an indication of the development of dysbiosis or other gut dysfunction. At the same time, a high concentration of MB (50 mg/kg/day) led to pronounced changes, primarily an increase in the levels of Delta, Gamma and Epsilonproteobacteria. Over 4 weeks of therapy, the treatment with high MB concentration has led to an increase in the median content of Proteobacteria to 7.49% vs. 1.61% in the control group. Finally, we found that MB at a concentration of 15 mg/kg/day improved the cognitive abilities of mice, while negative correlation between the content of Deferribacteres and cognitive parameters was revealed. Our data expand the understanding of the relationship between MB, cognitive abilities, and gut microbiome in respect to the antibacterial properties of MB.
Non-invasive fibrosis algorithms are clinically useful for excluding cirrhosis in prisoners living with hepatitis C
Authors: Papaluca Timothy , Craigie Anne , McDonald Lucy , Edwards Amy , MacIsaac Michael , Holmes Jacinta A. , Jarman Matthew , Lee Tanya , Huang Hannah , Chan Andrew , Lai Mark , Sundararajan Vijaya , Doyle Joseph S. , Hellard Margaret , Stoove Mark , Howell Jessica , Desmond Paul , Iser David , Thompson Alexander J.
Published: November 2020

Background and aims

Prison-based HCV treatment rates remain low due to multiple barriers, including accessing transient elastography for cirrhosis determination. The AST-to-platelet ratio index (APRI) and FIB-4 scores have excellent negative predictive value (NPV) in hospital cohorts to exclude cirrhosis. We investigated their performance in a large cohort of prisoners with HCV infection.

Methods

This was a retrospective cohort study of participants assessed by a prison-based hepatitis program. The sensitivity, specificity, NPV and positive predictive value (PPV) of APRI and FIB-4 for cirrhosis were then analysed, with transient elastography as the reference standard. The utility of age thresholds as a trigger for transient elastography was also explored.

Results

Data from 1007 prisoners were included. The median age was 41, 89% were male, and 12% had cirrhosis. An APRI cut-off of 1.0 and FIB-4 cut-off of 1.45 had NPVs for cirrhosis of 96.1% and 96.6%, respectively, and if used to triage prisoners for transient elastography, could reduce the need for this investigation by 71%. The PPVs of APRI and FIB-4 for cirrhosis at these cut-offs were low. Age ≤35 years alone had a NPV for cirrhosis of 96.5%. In those >35 years, the APRI cut-off of 1.0 alone had a high NPV >95%.

Conclusion

APRI and FIB-4 scores can reliably exclude cirrhosis in prisoners and reduce requirement for transient elastography. This finding will simplify the cascade of care for prisoners living with hepatitis C.
The metabotyping of an East African cassava diversity panel: A core collection for developing biotic stress tolerance in cassava
Authors: Perez-Fons Laura , Ovalle Tatiana M. , Maruthi M. N. , Colvin John , Lopez-Lavalle Luis Augusto Becerra , Fraser Paul D.
Published: November 2020

Cassava will have a vital role to play, if food security is to be achieved in Sub-Saharan Africa, especially Central and East Africa. The whitefly Bemisia tabaci poses a major threat to cassava production by small holder farmers in part due to their role as a vector of cassava mosaic begomoviruses (CMBs) and cassava brown streak ipomoviruses (CBSIs). In the present study untargeted metabolomics has been used as a tool to assess natural variation, similarities and attempts to identify trait differentiators among an East African cassava diversity panel that displayed tolerance/resistance to the effects of Bemisia tabaci infestation. The metabolome captured, was represented by 1529 unique chemical features per accession. Principal component analysis (PCA) identified a 23% variation across the panel, with geographical origin/adaption the most influential classification factors. Separation based on resistance and susceptible traits to Bemisia tabaci could also be observed within the data and was corroborated by genotyping data. Thus the metabolomics pipeline represented an effective metabotyping approach. Agglomerative Hierarchical Clustering Analysis (HCA) of both the metabolomics and genotyping data was performed and revealed a high level of similarity between accessions. Specific differentiating features/metabolites were identified, including those potentially conferring vigour to whitefly tolerance on a constitutive manner. The implications of using these cassava varieties as parental breeding material and the future potential of incorporating more exotic donor material is discussed.
La “ventaja del síndrome de Down” en la calidad de vida de jóvenes con discapacidad intelectual
Authors: Berástegui Ana , Corral Sara
Published: November 2020

El objetivo del estudio fue examinar el fenómeno descrito en la literatura como la “ventaja del síndrome de Down” en la calidad de vida familiar e individual de jóvenes con discapacidad intelectual (DI). La muestra la formaron 84 jóvenes con DI (Edad media 21,41 años; DT = 2,87), de los que 20 tenían síndrome de Down (SD) (23,81 %). Los instrumentos utilizados fueron la Escala de Calidad de Vida Familiar (CVF) y la Escala INICO-FEAPS, en su versión informada por otros (CVI-H) y autoinforme (CVI-A). Los resultados reflejan mayores puntuaciones en CVF y CVI-H en las familias de los jóvenes con SD y menores en CVI-A que en los jóvenes sin SD. Ni la edad de los padres ni el nivel de ingresos se relacionaron con estas variables. Que las diferencias en calidad de vida familiar e individual se den cuando informan los progenitores, pero se inviertan en la versión autoinformada, sugiere una explicación del fenómeno no causal sino relacionada con las expectativas familiares y su acceso a recursos y apoyos, y nos impulsa a dar importancia a la visión de la persona en la evaluación de la calidad de vida de los jóvenes con DI.
METHODS OF ENDURANCE DEVELOPMENT GIRLS 16–17 YEARS OLD
Authors: Kuzntsova Elena Valerievna , Kovyazina Galina Viktorovna
Published: November 2020

The article deals with the modern problem of developing the endurance of girls aged16–17 years by means of fitness, the feasibility of using fitness as a modern type of physical activity.Endurance is one of the most important physical qualities needed in the rapidly changing realities ofmodern life-in physical and psychological aspects. Endurance is a multifunctional property of thehuman body and integrates a large number of processes that occur at various levels: from the cellularto the whole organism. The leading role in the manifestation of endurance belongs to the factors ofenergy metabolism and the vegetative systems that provide it, namely, the cardiovascular, respiratory,and Central nervous system. Endurance training has a beneficial effect on a person”s mental stability.It educates moral and volitional qualities, and especially forms patience and the preservation ofpsychological stability to the effects of external factors. In the modern world, these advantagesare especially important, because life activity in conditions of constant stress, the requirementsof accelerated adaptation, reaction, and the influence of external stimuli becomes difficult for aperson, sometimes unbearable and leads to” emotional burnout “and Manager”s syndrome”. Thehealth of the nation and future generations is largely determined by the health of women. Womenare a large and active part of the population of our country, performing both reproductive anda number of important social functions. Their high-quality performance requires a high level ofmental and General physical stability, namely endurance. Fitness is a progressive trend that integratesphysical activity, proper nutrition, adherence to healthy lifestyle, and is also interesting to younggirls as a modern youth direction of physical activity. The age of 16–17 years is part of the sensitiveperiod of girls “endurance development. A comprehensive assessment of the method of endurancedevelopment is based on changes in the level of General, coordination, strength and psychologicalendurance, changes in the indicators of the cardio-respiratory system and the psychological and emotional component. In order to test the working hypothesis, a natural open parallel pedagogicalexperiment was conducted. The method of endurance development based on a combination ofmeans and methods of classical aerobics, power aerobics, functional, jumping-running and recoveryexercises, combined in qualitative and quantitative composition, with a clear pattern of alternatingtypes of fitness classes and regular use of developed sets of exercises created for girls of high schoolage. According to the results of the experiment, it was found that the functional state of the subjectsimproved, and the necessary training and psychological effect was achieved. The presented analysisof the research results proves the effectiveness of the developed methodology for the developmentof endurance.
Vocabulário escrito de estudantes e de materiais didáticos do Ensino Fundamental nas redes públicas municipal e estadual de educação
Authors: Silva Bruna Rodrigues
Published: November 2020

Este artigo relata o primeiro estudo piloto de pesquisa de mestrado na área dos estudos do léxico, e se dedica a identificar o perfil de vocabulário escrito de estudantes do Ensino Fundamental. O objetivo é descrever, de maneira inicial, o vocabulário de alunos do Ensino Fundamental nas redes públicas municipal e estadual de educação. O vocabulário dos estudantes é examinado conforme manifestado em suas produções escritas e é contrastado com o de textos de materiais didáticos por eles utilizados. Com o apoio da estatística linguística (BIDERMAN, 1978, 1998) e da Linguística de Corpus (BERBER SARDINHA, 2004), a ideia é gerar contrastes e diferenciações entre esses dois universos. Foram examinados oito textos de alunos, dois textos de livros didáticos, além de um texto de apoio, utilizado junto com a proposta de produção textual. Os elementos observados, nas três fontes textuais, foram o número de tokens e de types, a frequência das palavras, a diferença entre as ocorrências de palavras lexicais e gramaticais, o hapax legomena e a riqueza vocabular. Os resultados indicam que a riqueza vocabular dos textos dos alunos não varia entre as duas escolas e que não há diversidade de palavras. Ao analisar as vinte palavras mais frequentes, nota-se que as que mais aparecem também estão presentes no texto de apoio, contudo, o repertório vocabular dos textos dos livros didáticos não é utilizado pelos estudantes. O estudo evidencia a necessidade de maior ponderação quanto ao número de textos a serem observados nos diferentes segmentos do corpus sob exame.
El diccionario (semi)bilingüe como obra lexicográfica contrastiva y pedagógica
Authors: Bueno Rejane
Published: November 2020

Los repertorios lexicográficos (semi)bilingües fueron constantemente reinterpretados en la Metalexicografía porque presentan características de obras monolingües y, a la vez, bilingües, configurándose como repertorios lexicográficos de difícil concepción debido a su carácter lingüístico y lexicográfico híbrido. A través de un recorrido por los aportes de la Lingüística contrastiva, la Lexicografía bilingüe contrastiva y la Lexicografía pedagógica, el objetivo de este artículo es suscitar algunas reflexiones en el entorno de los diccionarios (semi)bilingües ampliando su concepción tradicional y caracterizándolos desde la perspectiva teórica y práctica como obras lexicográficas bilingües contrastivas que puedan utilizarse en la enseñanza de lenguas.
Structure of differed Marandu palisade grass with variables nitrogen doses and heights
Authors: Soares Flávia , Miranda da Fonseca Dilermando , Moraes de Oliveira Davi , Carla Adorno Lorena , Barcelos Gois Kimberly , Segatto Borges Gustavo , Rozalino Santos Manoel Eduardo
Published: November 2020

This study aims to evaluate the effects of height (15 and 30 cm)and nitrogen dose (N, 40, 80, and 120 kg ha-1) at the beginning of thestockpiling period on the structural characteristics of the Urochloabrizantha cv. Marandu (Marandu palisade grass) during winter. Thefalling index of the plant did not vary with the factors under scrutiny(P>0,10). The number of basal tillers was higher (P<0,10) in the 15-cmdeferred canopy than in the 30-cm canopy only when the highest N dosewas used. Under conditions of application of 0 or 80 kg ha-1 of N, the 30-cmstockpiled canopies showed a higher (P<0,10) forage mass than the 15-cmones. Associated with reduced canopy height at the beginning ofstockpiling period, nitrogen fertilization improves the morphologicalcomposition of Marandu palisade grass. To maximize the forage mass inthe dry season, the canopies of Marandu palisade grass can be deferredeither at 15 cm (fertilized with about 100 kg ha-1 of N) or at 30 cm (with nonitrogen fertilization) at the beginning of the stockpiling period.
Inaugurated Hyperspace
Authors: Page Ben
Published: November 2020

Several philosophers of religion have used contemporary work on the metaphysics of space to dismantle objections to Christian doctrine. In this paper I shall also make use of work in the metaphysics of space to explore a topic in Christian thought that has received little attention by philosophers, namely inaugurated eschatology. My aim will be to take the conclusions of some biblical scholars who have written on this topic, and then begin to provide some metaphysical models of this doctrine, so as to overcome objections against inaugurated eschatology based on metaphysical concerns.
Factors Influencing Digital Reading Behaviour of Students
Authors: Haneefa K Mohamed , P Divya
Published: November 2020

The main aim of the study was to explore the factors influencing digital reading behavior of students. A survey with stratified random sample of 588 postgraduate students from the teaching departments of the universities in Kerala was used to conduct the study. The analysis revealed that majority of the students opined that with the availability of laptop, mobile phone and the Internet, their digital reading increases. There exists significant gender difference in the opinion of the students about the features like save, download, search, find and bookmark that helped them to read digitally. About half of the students mentioned that the factors like font size, text layout, type face and background colour are highly influencing while reading digitally. The students also responded that digital reading increases their selective reading, superficial reading, interactive reading, and decreases their in-depth reading, concentrated reading and sustained attention. Male students have significantly higher influence of e-resources on their reading practices than those of female students. This study is useful for professionals who are developing e-contents, e-resources and different types of e-learning interfaces
Revealing Chemopreventive Potential of Active Constituents from Medicinal Herbs Used in Indonesia for (Metastatic) Breast Cancer with Particular Molecular Targets
Authors: Indrasetiawan Puguh , Haryanti Sari , Meiyanto Edy
Published: November 2020

Breast cancer remains as one of the highest causes of cancer-related deaths in the world, including Indonesia. In spite of following the standard protocol therapy, some patients in developing countries consume medicinal herbs as an alternative, complementary, as well as supportive therapies. Several herbs have been recognized to be used for this purpose. Annona muricata, Curcuma longa, Curcuma zanthorrhiza, Curcuma zedoaria, Phyllanthus urinaria, Gynura procumbens, Garcinia mangostana, Morinda citrifolia, and Nigella sativa are some of the plants used as chemopreventive agents with several formulas. Various types of extracts of Annona muricata show anticancer activities in vitro and in vivo. Curcumin, obtained from Curcuma longa and Curcuma zanthorrhiza, acts as p53 regulator and pro-oxidant in MCF-7 cells and also acts as a fatty acid synthase inhibitor in MDA-MB-231 cells. Xanthorrhizol from Curcuma zanthorrhiza has pro-apoptotic activity via modulation of Bcl-2, p53, and PARP-1 protein levels. Curcuma zedoaria contains curcumenone, curcumenol and curdion, which show pro-apoptotic activity in various cell lines and a cancer-induced mouse model. Corilagin and geraniin from Phyllanthus urinaria have different pro-apoptotic effects, in which, the corilagin-caused apoptotic effect is mediated by extrinsic and mitochondrial pathways, whereas geraniin induces apoptosis via ROS-mediated stimulation, both in MCF-7 cells. Thymoquinone from Nigella sativa has been extensively studied for its anticancer activities in recent years. Plants are cultivated, collected and mixed depending on the use as herbal medicines. Active compounds might be formulated if deemed possible. The development of more potential derivatives is also necessary to produce more optimum anti-cancer agents. In conclusion, Indonesian plants and their active constituents show potential activities to be developed as chemopreventive agents.Keywords: Indonesian medicinal herbs, breast cancer, active constituents, molecular targets
Exploring foreign entrepreneurial ecosystems through virtual exchange
Authors: Cheikhrouhou Nadia , Marchewka Małgorzata
Published: November 2020

This case study reports a Virtual Exchange (VE) between students at Cracow University of Economics (Poland) enrolled in business courses and students from the High Institute of Technological Studies of Béja (Tunisia) enrolled in an entrepreneurship course. The main aim of the project was to enhance students’ awareness of similarities and differences between the Polish and the Tunisian entrepreneurial ecosystems. The goals also included improving language skills, Information and Communication Technology (ICT) literacy, teamwork, and increasing their self-confidence. The chapter describes the schedule of the project, tasks that students accomplished, and the technological and communication tools that were used. Finally, the study includes conclusions and suggestions for future initiatives.
Communication across cultures: when the virtual meets the classroom
Authors: Giralt Marta
Published: November 2020

This chapter showcases the implementation of an E+VE (Erasmus+ Virtual Exchange) project in a ‘broadening module’ (elective content-specific modules offered across the university curricula) at the University of Limerick (UL), entitled ‘Communication Across Cultures’. The pedagogical approach follows a blended learning model where face-to-face lectures are combined with the Cultural Encounters programme series of iOOCs (interactive Open Online Courses) offered by E+VE. This pedagogical practice has received positive feedback due to the practical appropriateness and effectiveness of the VE to the module, and has also been successful in terms of intercultural awareness and learning, in addition to the development of intercultural competence and communication skills.
A review on thermo-physical properties of bio, non-bio and hybrid nanofluids
Authors: Chen James Lau Tze , Oumer Ahmed N. , A. A. Azizuddin
Published: November 2020

The pressure drop and thermal performance of various nanofluids can be affected by their thermo-physical properties. However, there are many different parameters that need to be considered when determining the thermo-physical properties of nanofluids. This paper highlights a detail reviews on the thermo-physical properties of nanofluids with different material type and effect of some process parameters (such as material type, temperature and concentration) on the thermo-physical properties of nanofluids. Four thermo-physical properties mainly density, viscosity, thermal conductivity and specific heat capacity from different literatures were summarized, discussed and presented. The lowest viscosity value of nanofluids in literature was mango bark water-based nanofluid (0.81cP). On the other hand, the maximum thermal conductivity value of nanofluids in the literature was GNP-Ag water-based nanofluid (0.69W/mK). The density and specific heat capacity are strongly dependent on the material type. Meanwhile, the viscosity and thermal conductivity are greatly affected by temperature and concentration. The most influential parameters on thermo-physical properties of nanofluids are material type followed by temperature. Most of the literatures confirmed bio nanofluids have low viscosity value and hybrid have high thermal conductivity values.
Investigación e innovación en educación en ingeniería
Authors: Cristian Alexander Vega Mosquera , Camilo Alejandro Corchuelo Rodriguez , Luz Marina Paez
Published: November 2020

Este informe de entrega una consulta del estado de las patentes del tema “Investigación e innovación en educación en ingeniería” de forma general. Se presenta la publicación y presentación por año, las palabras con mayor concurrencia, información de asignación por solicitantes y caracterización por industria y países. Este es un insumo para la comunidad académica USTA cuyo objetivo es potenciar la trasferencia de conocimiento y tecnología al sector productivo del país.
Age-related changes of some chemical components in the leaves of sweet chestnut (Castanea sativa Mill.)
Authors: Turfan Nezahat , Ayan Sezgin , Yer Çelik Esra Nurten , Ozel Halil Baris , Onat Saadettin Murat
Published: November 2020

The aim of this study was to investigate the developmental physiology of sweet chestnut trees (Castanea sativa Mill.) of different age groups (≥ 25, ≥ 50, ≥ 100, ≥ 200, and ≥ 400) in the Catalzeytin district of Kastamonu, Turkey. For this purpose, photosynthetic pigments, proline, total soluble protein, glucose, sucrose, total soluble carbohydrate and starch values, malondialdehyde (MDA) and hydrogen peroxide (H2O2) concentration, and also ascorbate peroxidase (APX), catalase (CAT), and superoxide dismutase (SOD) activities were measured in leaf samples. Hence, significant differences were found in the amounts and concentrations of all types of chlorophyll, carotenoid, proline, total soluble protein, glucose, sucrose, total soluble carbohydrate, starches, MDA, H2O2, APX, CAT, and SOD among the trees of different age groups. While the chlorophyll a value was low in young trees, the chlorophyll b value was low in older trees. It was determined that the MDA content was high in old trees, whereas it was low in young trees. While the amounts of glucose, sucrose, total soluble carbohydrate, and starch were highest in ≥ 400-year-old trees, they were lowest in the young trees. Both APX and CAT activities were high in young trees, whereas SOD activity was lowest in ≥ 400-year-old trees.
Comparison of internet-based versus paper-and-pencil administered assessment of positive development indicators in adolescents' sample
Authors: Vosylis Rimantas , Žukauskienė Rita , Malinauskienė Oksana
Published: November 2020

The aim of this study was to evaluate the use of the online data collection method to survey adolescents about their psychological characteristics in a follow up-longitudinal study on positive youth development in order to test the psychometric equivalence of two assessment methods. 1030 participants (17–19 years old) completed paper-and-pencil questionnaires in schools (505 boys and 525 girls), 132 (28 boys and 104 girls) completed Internet-based questionnaires, and 47 (15 boys 32 girls) completed both, measuring positive development indicators. The findings suggest that adolescents report less socially desirable behaviour and active citizenship in Internet-based questionnaires, but generally Internet-based administration does not have any differences in the means values of positive development indicators as compared to paper-and-pencil administration. Internet-based questionnaires have higher or similar internal consistencies as compared with paper-and-pencil questionnaires and are highly correlated with each other when administered using Internet-based and paper-and-pencil assessment. There is no interaction effect of the Internet versus paper-and-pencil assessment and the sex of adolescents on the positive development indicators. Limitations of this study are discussed.
The types of suicide process among psychoactive substance users
Authors: Rimkevičienė Jurgita , Gailienė Danutė
Published: November 2020

Research regarding the role of psychoactive substance use in the process of suicide is lacking in current sui­cidology. In addition to this, evidence shows that im­pulsive suicide attempts are common among substance users. However there is no clear understanding of the impulsive suicide process. That makes it difficult to combine results of different studies and create clear guidelines for impulsive suicide risk evaluation. The purpose of this research is to depict the impulsive and non-impulsive process of suicide among psychoactive substance users.  The participants of the study were 15 psycho­active substance (10 – alcohol, 5 – drug) users, who had attempted suicide during the last year. 8 of them attempted once, 4 – two or three times, other 3 – more than 5 times. All participants – 4 women and 11 men were patients from Vilnius Centre for Addictive Disorders and Vilnius Mental Health Centre. Quali­tative interviews based on Suicide Intent Scale were conducted about the suicide attempt or attempts. A thematic analysis of the interviews was used to depict the process of suicide. This study led to distinguishing 3 different types of attempted suicide – planned, unplanned and suicide attempts during a “blackout” – which are typical for psychoactive substance users. Both unplanned suicide attempts and suicide attempts during a “blackout” can be called impulsive, though the latter diverged by their hastiness, aggressiveness, inability to control one’s behaviour, intensive feeling of anger, serious danger caused to health and wellbeing, as well as a follo­wing amnesia of a major part of the suicide attempt. Intensive emotions, especially anger and stressors in interpersonal relationships, had a major impact for the respondents in the process of suicide. According to the participants of the survey, substance use had intensified their suicidal crisis having a clear effect on their emotional, relationship and other difficulties. In addition, alcohol and drug use was considered as one of the suicide methods. Despite several restrictions of the research, the study results provide some valuable insight in the suicide risk evaluation among psycho­active substance users.
Nyitott hasi aortaaneurysma-műtétek patkóvese fennállása esetén
Authors: Bálint Sándor , Mihály Zsuzsanna , Oláh Zoltán , Sótonyi Péter
Published: November 2020

Összefoglaló. A patkóvese a vese leggyakrabban előforduló fejlődési
rendellenességeinek egyike. Hasi aortaaneurysmával való együttes előfordulása
kifejezetten ritka (a hasi aortaaneurysmás esetek 0,12%-a). Az első esetben egy
64 éves férfi akut alsó végtagi panaszokkal került felvételre. A CT-angiográfia
patkóvesét és thrombotizált infrarenalis aortaaneurysmát igazolt. Az akut műtét
során a hasi aortaaneurysma resectióját és aortobifemoralis bypassműtétet
végeztünk a patkóvese ishmusának megtartásával. A második esetben hasi
panaszokat okozó, mindkét arteria iliaca communisra ráterjedő infrarenalis
aortaaneurysma esetén végeztünk aortobiiliacalis rekonstrukciót. Az aneurysma
előtt elhelyezkedő isthmus tervezetten szétválasztásra került, a poláris
veseartériát visszaültettük. A tünetes hasi aortaaneurysma abszolút műtéti
indikációt képez. A preoperatív CT- vagy MR-angiográfia kulcsfontosságú mind a
műtéti indikáció felállítása, mind pedig a műtét megtervezése szempontjából. A
beavatkozás előtt pontos képet kell kapnia az érsebésznek az aorta anatómiája
mellett a patkóvese vérellátásáról és a húgyúti rendszerről. Az érsebészeti
rekonstrukció esetén a transperitonealis feltárás – főleg akut műtét esetén –
több előnnyel rendelkezik, mint a retroperitonealis feltárás. Orv Hetil. 2020;
161(46): 1966–1971.

Summary. Horseshoe kidney is one of the most common congenital
disorders of the kidney. The simultaneous incidence of horseshoe kidney and
abdominal aneurysm is very low (0.12% of all cases of abdominal aortic
aneurysm). In the first case, a 64-year-old male patient was admitted with acute
lower limb ischaemia. CT-angiography revealed an occluded aortic aneurysm.
During the emergency operation, the abdominal aneurysm was resected and an
aortobifemoral bypass procedure was performed sparing the kidney’s isthmus. In
the second case, the abdominal complaints were caused by an infrarenal abdominal
aneurysm that involved both common iliac arteries. Aortobiiliac reconstruction
was performed with planned separation of the kidney isthmus and reimplantation
of the accessory renal artery. Symptomatic abdominal aortic aneurysm is an
urgent indication for reconstruction. The preoperative CT- or MR-angiography
play a key role in the indication and planning of the reconstruction. It is
highly important for the vascular surgeon to have a clear picture of the blood
supply of the horseshoe kidney and the urinary tract along with the anatomy of
the aorta before the operation. The transperitoneal approach has several
advantages over the retroperitoneal approach during vascular reconstruction
surgery. Orv Hetil. 2020; 161(46): 1966–1971.
Role of ratio-based metrics in cardiology
Authors: Konradi A. O. , Maslyansky A. L. , Kolesova E. P. , Shlyakhto E. V. , Kerkhof P. L.M.
Published: November 2020

In cardiovascular studies, two related parameters that determine the same physical variable are often recorded. Interpretation of the calculated indicators presented in the form of ratios and differences is difficult, since they can be associated with several combinations of primary data giving the same value.

Aim.To find a way to overcome this limitation and take a more comprehensive approach.

Material and methods.We analyzed the data on left ventricular volume and blood pressure (BP) in 275 patients (women — 207), obtained using echocardiography and BP monitor. To calculate a lost companion (c) value based on a difference or dimensionless ratio, we applied the Pythagorean theorem. The lost companion is

defined as the hypotenuse in each study area. To calculate the pulse pressure companion (PP), the following formula was used: PP(c)=Ö(SBP2+SBP2). Similar methods were applied to ejection fraction (EF), augmentation pressure (AG) and AG/PP ratio, resulting in the ratio called augmentation index (AIx).

Results.1. Mean blood pressure (MBP) acts as a surrogate for the PP companion (PPc) values (R=0,970, N=257). 2. We have identified correlations between PPc and pulse wave velocity (R=0,397, N=193), and AGc with AIx (75) (R=0,662, N=198). 3. EF has an inverse relationship with the end diastolic volume (EDV) (R=-0,559, N=187), and the ventricular-arterial coupling (VAC) correlates with ESV (r=-0,627, N=180). 4. Comparison of EDV and VACc revealed R of 0,949.

Conclusion.Companions calculated from the available data can have significant additional diagnostic value without the need for additional measurements. It is important to note that the combination of traditional ratio-based and suggested companions allows for more accurate data on individual patients.
The combination of left ventricular non-compaction and hypertrophic cardiomyopathy in one family with a pathogenic variant in the MYBPC3 gene (rs397516037)
Authors: Myasnikov R. P. , Kulikova A. V. , Meshkov A. N. , Mershina E. A. , Kiseleva A. V. , Klimushina M. V. , Divashuk M. G. , Kurilova O. V. , Pilyus P. S. , Kharlap M. S. , Koretsky S. N. , Larina O. M. , Sinitsyn V. E. , Gandaeva L. A. , Barsky V. I. , Basargina E. N. , Boytsov S. A. , Drapkina O. M.
Published: November 2020

The article presents the results of clinical, instrumental and molecular genetic tests of three generations of a family with inherited cardiomyopathy caused by a new variant in the MYBPC3 gene. A specific feature of this case is the phenotypic heterogeneity of the mutation — a combination of hypertrophic cardiomyopathy and left ventricular non-compaction in family members. Attention is drawn to the various severity of clinical manifestations in relatives of carriers of mutation: from asymptomatic to severe heart failure and acute cerebrovascular accident.
CLUBE DE CIÊNCIAS: DISCUTINDO GÊNERO, IDENTIDADE E A VALORIZAÇÃO-INSERÇÃO DE MENINAS NO CAMPO CIENTÍFICO
Authors: Silva Andrade Maria Estela , Hora da Silva Amanda Carolina , Teixeira Araújo Paula , De Bastos Vieira Rui Manoel , De Carvalho Piassi Luís Paulo
Published: November 2020

O presente artigo visa apresentar os resultados parciais de uma aplicação realizada no grupo/projeto L.I.R.A. sobre a percepção de um grupo de meninas a respeito do papel delas na sociedade e nas ciências, bem como refletir sobre como essa percepção, tanto de si quanto do outro, afeta a construção de suas identidades. A análise dos dados foi feita através de uma metodologia qualitativa com a aplicação de um grupo focal que teve como foco o discurso das participantes sobre o tema pesquisado. Os resultados parciais demonstraram que embora as meninas apresentem interesse por ciências e por algumas de suas áreas específicas: matemática, engenharia entre outras, sofrem preconceito de gênero por parte de amigos e familiares por esses não acreditarem em sua capacidade. Logo, a discussão sobre essa tema se mostrou de grande relevância não só para os objetivos da pesquisa, mas também para incentivar as meninas a pensarem sobre essa temática e se inserirem na área científica.
EDUCAÇÃO AMBIENTAL: PROCESSO DE AMBIENTALIZAÇÃO DE UNIVERSIDADES CATARINENSES
Authors: Lima Lucia Ceccato de , Pissetti Schayla Letyelle Costa , Vaz Mauricio Augusto de Farias
Published: November 2020

Esta pesquisa objetivou conhecer as ações ambientais que tem contribuído com o processo de ambientalização de universidades catarinenses como estratégia de educação ambiental no ensino superior. O referencial teórico que fundamentou a discussão a respeito da ambinetalização foi alicerçado em Kitzmann (2012) e Guerra e Figuiredo (2014). A ambientalização caracteriza-se pela inserção e discussão da dimensão ambiental onde ainda não acontece. A metodologia em uma abordagem qualitativa, realizou a coleta de dados por meio do preenchimento de um quadro de referência por representantes das universidades participantes do Projeto de Pesquisa: Ambientalização e Sustentabilidade na Educação Superior: Subsídios às Políticas Institucionais em Santa Catarina – Chamada Pública FAPESC nº 01/2014 – Programa Universal – 2014 a 2017. Como resultado obteve – se categorias com ocorrência nas quarto dimensões de ambientalização da universidade: ensino, pesquisa, extensão e gestão. São elas: Fortalecimento de Linhas de Pesquisa, realização de pesquisa, dissertações, iniciação a pesquisa e dissertações sobre o tema; Programa de Educação Ambiental; Inserção de disciplinas e ou conteúdo de Educação Ambiental; Divulgação de livro, artigos guias sobre o projeto; Realização e organização de palestras, eventos e Rede (RASES) sobre ambientalização; Regulamentação de políticas de ambientalização nas Universidades. Dessa forma, pode–se conhecer sobre a importância de projetos interinstitucionais e financiados para mobilizar a comunidade acadêmica e contribuir com a ambientalização institucional. Afinal, ambientalizar é levar a discussão do cuidado do ambiente para dentro das salas de aula, grupos de pesquisa, setores administrativos e comunidade externa. Reconhece–se que as categorias apresentadas representam inúmeras ações ambientais que tem contribuído com o processo de ambientalização de universidades catarinenses como estratégia de educação ambiental no ensino superior.