bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifying Offspring Sex Ratio Skews in Zoological Facilities Using Large Historical Datasets
Authors: Machado Julia M. , Miller Lance J.
Published: November 2023

The Fisher principle states that species should produce offspring at a ratio of 1:1 unless there are sex-specific differences in rearing costs. Research conducted across taxa has found that animals will vary the sex ratio of their offspring so as to maximize personal fitness in response to various ecological and biological variables. This phenomenon has been especially well studied within the Avian class. Professionally managed populations provide a useful framework within which to study the impacts of numerous variables on sex allocation strategies. Zoological facilities may be especially motivated to investigate this phenomenon due to corresponding conservation and welfare implications. We analyzed a large dataset containing the demographic data of over 1 million zoo-housed birds for species-specific offspring sex ratio biases. The offspring sex ratios of 19,867 zoo-hatched dams were calculated, and the median offspring sex ratio of 277 species from 25 orders was calculated across two 20-year time periods. We used a Wilcoxon signed rank tests with a Holm Bonferroni alpha criterion in order to determine if species medians differed from parity. Only one species in one time period displayed a significant species median offspring sex ratio. The limits of our dataset are discussed. We propose that future research should further explore the determinants of sex allocation strategies for species held within zoological facilities.
Multimodal Ophthalmic Imaging in Spinocerebellar Ataxia Type 7
Authors: Ciancimino Chiara , Di Pippo Mariachiara , Manco Gregorio Antonio , Romano Silvia , Ristori Giovanni , Scuderi Gianluca , Abdolrahimzadeh Solmaz
Published: November 2023

The aim of this case series and narrative literature review is to highlight the importance of multimodal imaging in the ophthalmological examination of patients with spinocerebellar ataxia type 7 and provide a summary of the most relevant imaging techniques. Three patients with SCA7 were included in this case series. A literature review revealed twenty-one publications regarding ocular manifestations of SCA7, and the most relevant aspects are summarized. The role of different imaging techniques in the follow-up of SCA7 patients is analyzed, including color vision testing, corneal endothelial topography, color fundus photography (CFP) and autofluorescence, near infrared reflectance imaging, spectral domain optical coherence tomography (SDOCT), visual field examination, and electrophysiological tests. SDOCT provides a rapid and non-invasive imaging evaluation of disease progression over time. Additional examination including NIR imaging can provide further information on photoreceptor alteration and subtle disruption of the RPE, which are not evident with CFP at an early stage. Electrophysiological tests provide essential results on the state of cone and rod dystrophy, which could be paramount in guiding future genetic therapies. Multimodal imaging is a valuable addition to comprehensive ophthalmological examination in the diagnosis and management of patients with SCA7.
Obesity and Bone Mineral Density Protection Paradox in Chronic Kidney Disease: Secreted Protein Acidic and Rich in Cysteine as a Piece of the Puzzle?
Authors: Ghanemi Abdelaziz , Mac-Way Fabrice
Published: November 2023

Obesity is a health condition that represents a risk factor for numerous diseases and complications. However, obesity might also have—to some extent—some “benefits” in certain situations. This includes potential bone protection in patients suffering from chronic kidney disease. In an attempt to explain such a paradox, we highlight secreted protein acidic and rich in cysteine (SPARC) as a hypothetical mediator of this protection. Indeed, SPARC properties provide a logical rationale to describe such bone protection via its overexpression combined with its calcium-binding and collagen-binding properties. We believe that exploring such hypotheses could open new doors to elucidate unknown pathways towards developing a new generation of molecular therapies.
Dynamic Capabilities and Digital Transformation in the COVID-19 Era: Implications from Driving Schools
Authors: Kitsios Fotis , Nousopoulou Evangelia , Kamariotou Maria
Published: November 2023

Background: The COVID-19 pandemic is a worldwide threat that has positioned micro-enterprises under enormous tension to persevere. As a result, these businesses are obligated to respond to the epidemic in an efficacious manner. In order to weather this economic storm, micro-enterprises have implemented a variety of digital technologies. Methods: The research investigates the connection between the communications technology of driving schools and the public crisis responses of those driving schools using a data set obtained from a survey administered to those schools. Results: The quantitative findings demonstrate that digitalization has made it possible for driving schools to efficiently and successfully respond to the public dilemma by utilizing their resilient functionality. In addition, digitalization can greatly enhance driving schools’ performance. Conclusions: This paper provides drawings for digitalization and crisis responses for driving schools.
Enhancing the Performance of Rapeseed Oil Lubricant for Machinery Component Applications through Hybrid Blends of Nanoadditives
Authors: Nassef Belal G. , Pape Florian , Poll Gerhard
Published: November 2023

Bio-lubricants have demonstrated promising tribological and physical properties, suggesting their potential advantages in the lubrication of critical machinery components. This study investigates the impact of using blended individual and hybrid nanoadditives, such as graphene nanoplatelets, ZnO, and an ionic liquid (IL) of Trihexyltetradecylphosphonium bis(2,4,4-trimethylpentyl)phosphinate, on the rheological, tribological, and physical characteristics of rapeseed oil. A commercial cutting fluid (BLASER Vasco 6000) (VB 6000) is used for comparison. The results revealed a substantial improvement in viscosity index (VI) values for mixtures containing graphene nanoplatelets, reaching up to 150%, as compared to VB 6000. Regarding the tribological behavior, the friction coefficient achieved a reduction of up to 20% at room temperature (RT) and 26% at 60 °C for the hybrid containing all three nanoadditives (H3), outperforming the commercial fluid. Moreover, H3 demonstrated the most substantial reductions in wear volume (84%) and surface roughness (60%). The wettability of H3 benefited from the combined mechanisms of the applied nanoadditives; its application the contact angle decreased by 63%, revealing its outstanding spreadability. The results reveal the high potential of the H3 hybrid as a competitive and green metal working fluid that can replace hostile and toxic ones in industrial applications.
The Influence of Acid Casein on the Selected Properties of Lime–Metakaolin Mortars
Authors: Brzyski Przemysław , Boris Renata
Published: November 2023

One of the ways to modify selected parameters of lime mortars is the use of biopolymers of animal origin, such as bone glue, skin glue, bovine blood, eggs, and casein. These are protein-based biopolymers. Casein is an example of an organic polymer produced from cow’s milk. The aim of the work was to investigate the possibilities of improving selected properties of mortars based on hydrated lime and metakaolin. The mixture was modified with powdered technical casein in amounts of 0.5%, 1.5%, 1%, 1.5%, and 2% as a partial mass replacement for the binding mixture. Additionally, the influence of increasing the amount of water on the properties of the mortar with a casein admixture of 2% was checked. This study examined consistency, shrinkage, water absorption, capillary action, porosity, flexural, compressive strength, and Young’s modulus. The admixture of casein influenced the properties of the mortar, but not in all cases, and it was possible to determine a clear trend related to the variable amount of casein. Strength properties deteriorated as the amount of casein increased. When air bubbles were introduced into the mortar after the casein was dissolved, the porosity increased as the amount of admixture increased. The moisture properties improved; namely, casein led to a reduction in water absorption and water absorption caused by capillary action. No relationship was observed between the amount of casein and the drying shrinkage. Increasing the amount of water in the mixture led to the expected effects, i.e., an increase in porosity, shrinkage, and water absorption, and a decrease in mechanical strength.
Critical Review on Magnetically Impelled Arc Butt Welding: Challenges, Perspectives and Industrial Applications
Authors: Chaturvedi Mukti , Vendan Subbiah Arungalai , Simion George , Rusu Carmen Catalina , Scutelnicu Elena
Published: November 2023

Magnetically Impelled Arc Butt (MIAB) welding is a cutting-edge joining method that replaces the conventional welding procedures such as resistance, friction, flash and butt welding. It is a solid-state process that uses a rotating arc to heat up the butt ends of tubes, being followed by a forging process that completes the joining of the workpieces The magnetic flux density and the current interact to develop the Lorentz force that impels the arc along the faying surfaces. This process is found to produce high tensile strength and defect-free welds in ferrous materials and for this reason, it is predominantly employed in automobile applications for joining metallic tubes. Also, this joining procedure can be applied in the fabrication of boilers, heat exchangers, furnace piping in petrochemical industry and other safety-critical high-pressure machinery parts. The MIAB method has several advantages such as a shorter welding cycle, lower input energy requirement and lower loss of material. Compared to other solid-state welding processes, the MIAB welding has an important advantage in terms of cost-efficient welds with better control and reliability. Moreover, there are researchers who have investigated the joining of non-ferrous dissimilar materials using this welding procedure. The studies have been focused on process parametric analysis that involves optimizing and forecasting the magnetic field and thermal profile distribution. This review article provides competitive insights into various design features, computational methods, tests and material characterization, technical issues and workarounds, as well as automation aspects related to the MIAB-welding process. This work will prove to be a quick reference for researchers, useful to identify the research gaps and conflicting ideas that can be further explored for advancements in joining the similar and dissimilar materials.
The Microstructures and Deformation Mechanism of Hetero-Structured Pure Ti under High Strain Rates
Authors: Wang Shuaizhuo , Yan Haotian , Zhang Dongmei , Hu Jiajun , Li Yusheng
Published: November 2023

This study investigates the microstructures and deformation mechanism of hetero-structured pure Ti under different high strain rates (500 s−1, 1000 s−1, 2000 s−1). It has been observed that, in samples subjected to deformation, the changes in texture are minimal and the rise in temperature is relatively low. Therefore, the influence of these two factors on the deformation mechanism can be disregarded. As the strain rate increases, the dominance of dislocation slip decreases while deformation twinning becomes more prominent. Notably, at a strain rate of 2000 s−1, nanoscale twin lamellae are activated within the grain with a size of 500 nm, which is a rarely observed phenomenon in pure Ti. Additionally, martensitic phase transformation has also been identified. In order to establish a correlation between the stress required for twinning and the grain size, a modified Hall–Petch model is proposed, with the obtained value of Ktwin serving as an effective metric for this relationship. These findings greatly enhance our understanding of the mechanical responses of Ti and broaden the potential applications of Ti in dynamic deformation scenarios.
Higher Order Sliding Mode Control of MIMO Induction Motors: A New Adaptive Approach
Authors: Karami-Mollaee Ali , Barambones Oscar
Published: November 2023

In this paper the objective is to force the outputs of nonlinear nonaffine multi-input multi-output (MIMO) systems to track those of a linear system with the desired properties. The approach is based on designing higher order sliding mode controller (HOSMC) with the definition of a new proportional-integral (PI) sliding surface. To this end, a linear state feedback with an adaptive switching gain (ASG) is applied to the nonlinear MIMO systems. Therefore, the switching gain can increase or decrease based on the system conditions. Then, the chattering is completely removed using a combination of HOSMC and ASG. Moreover, the proposed procedure is independent from the upper bound of the matched uncertainty, which is in the direction of system inputs. The finite time convergence to the sliding surface is also proved, which provides an invariance property in finite time. Note that invariance is the most important property of SMC. Finally, the general model of MIMO induction motors (IM) is used to address and to verify the proposed controller.
An Integrated Model of Deep Learning and Heuristic Algorithm for Load Forecasting in Smart Grid
Authors: Alghamdi Hisham , Hafeez Ghulam , Ali Sajjad , Ullah Safeer , Khan Muhammad Iftikhar , Murawwat Sadia , Hua Lyu-Guang
Published: November 2023

Accurate load forecasting plays a crucial role in the effective energy management of smart cities. However, the smart cities’ residents’ load profile is nonlinear, having high volatility, uncertainty, and randomness. Forecasting such nonlinear profiles requires accurate and stable prediction models. On this note, a prediction model has been developed by combining feature preprocessing, a multilayer perceptron, and a genetic wind-driven optimization algorithm, namely FPP-MLP-GWDO. The developed hybrid model has three parts: (i) feature preprocessing (FPP), (ii) a multilayer perceptron (MLP), and (iii) a genetic wind-driven optimization (GWDO) algorithm. The MLP is the key part of the developed model, which uses a multivariate autoregressive algorithm and rectified linear unit (ReLU) for network training. The developed hybrid model known as FPP-MLP-GWDO is evaluated using Dayton Ohio grid load data regarding aspects of accuracy (the mean absolute percentage error (MAPE), Theil’s inequality coefficient (TIC), and the correlation coefficient (CC)) and convergence speed (computational time (CT) and convergence rate (CR)). The findings endorsed the validity and applicability of the developed model compared to other literature models such as the feature selection–support vector machine–modified enhanced differential evolution (FS-SVM-mEDE) model, the feature selection–artificial neural network (FS-ANN) model, the support vector machine–differential evolution algorithm (SVM-DEA) model, and the autoregressive (AR) model regarding aspects of accuracy and convergence speed. The findings confirm that the developed FPP-MLP-GWDO model achieved an accuracy of 98.9%, thus surpassing benchmark models such as the FS-ANN (96.5%), FS-SVM-mEDE (97.9%), SVM-DEA (97.5%), and AR (95.7%). Furthermore, the FPP-MLP-GWDO significantly reduced the CT (299s) compared to the FS-SVM-mEDE (350s), SVM-DEA (240s), FS-ANN (159s), and AR (132s) models.
The Field Technician Scheduling Problem with Experience-Dependent Service Times
Authors: Yu Vincent F. , Lin Yueh-Sheng , Jodiawan Panca , Lin Shih-Wei , Lai Yu-Chi
Published: November 2023

This research studies the Field Technician Scheduling Problem with Experience-Dependent Service Times (FTSP–EDST), involving three main features: matching maintenance tasks with available technicians, sequencing the tasks, and considering the experience-dependent service times. Given a limited number of technicians, the objective is to maximize the collected profit for servicing tasks. This study formulates the problem as a mixed-integer linear programming model and proposes a Modified Iterated Local Search (MILS) to solve the benchmark problem instances of various sizes. A set of FTSP–EDST instances is generated based on existing publicly accessible data, and MILS is utilized to solve these newly generated instances. Computational results confirm the effectiveness of MILS in solving FTSP–EDST.
Giant Mandibular Ameloblastoma with Rare Hypercalcemia: A Case Report and Literature Review
Authors: Shen Wenyi , Xu Chenlu , Wang Pan , Chen Junpeng , Yu Dan , Zhu Huiyong
Published: November 2023

Ameloblastoma is the most common benign odontogenic tumor with local invasion and high recurrence, which generally occurs in the jaw bones. Hypercalcemia is a common paraneoplastic syndrome that is commonly observed in patients with malignancies but rarely encountered in patients with benign tumors. Thus far, not many cases of ameloblastoma with hypercalcemia have been reported, and the pathogenic mechanism has not been studied in depth. This paper presents a case report of a 26-year-old male diagnosed with giant ameloblastoma of the mandible, accompanied by rare hypercalcemia. Additionally, a review of the relevant literature is conducted. This patient initially underwent marsupialization, yet this treatment was not effective, which indicated that the selection of the appropriate operation is of prime importance for improving the prognosis of patients with ameloblastoma. The tumor not only failed to shrink but gradually increased in size, accompanied by multiple complications including hypercalcemia, renal dysfunction, anemia, and cachexia. Due to the contradiction between the necessity of tumor resection and the patient’s poor systemic condition, we implemented a multi-disciplinary team (MDT) meeting to better evaluate this patient’s condition and design an individualized treatment strategy. The patient subsequently received a variety of interventions to improve the general conditions until he could tolerate surgery, and finally underwent the successful resection of giant ameloblastoma and reconstruction with vascularized fibular flap. No tumor recurrence or distance metastasis was observed during 5 years of follow-up. Additionally, the absence of hypercalcemia recurrence was also noted.
Diaporthe Species on Palms: Molecular Re-Assessment and Species Boundaries Delimitation in the D. arecae Species Complex
Authors: Pereira Diana S. , Hilário Sandra , Gonçalves Micael F. M. , Phillips Alan J. L.
Published: November 2023

Due to cryptic diversification, phenotypic plasticity and host associations, multilocus phylogenetic analyses have become the most important tool in accurately identifying and circumscribing species in the Diaporthe genus. However, the application of the genealogical concordance criterion has often been overlooked, ultimately leading to an exponential increase in novel Diaporthe spp. Due to the large number of species, many lineages remain poorly understood under the so-called species complexes. For this reason, a robust delimitation of the species boundaries in Diaporthe is still an ongoing challenge. Therefore, the present study aimed to resolve the species boundaries of the Diaporthe arecae species complex (DASC) by implementing an integrative taxonomic approach. The Genealogical Phylogenetic Species Recognition (GCPSR) principle revealed incongruences between the individual gene genealogies. Moreover, the Poisson Tree Processes’ (PTPs) coalescent-based species delimitation models identified three well-delimited subclades represented by the species D. arecae, D. chiangmaiensis and D. smilacicola. These results evidence that all species previously described in the D. arecae subclade are conspecific, which is coherent with the morphological indistinctiveness observed and the absence of reproductive isolation and barriers to gene flow. Thus, 52 Diaporthe spp. are reduced to synonymy under D. arecae. Recent population expansion and the possibility of incomplete lineage sorting suggested that the D. arecae subclade may be considered as ongoing evolving lineages under active divergence and speciation. Hence, the genetic diversity and intraspecific variability of D. arecae in the context of current global climate change and the role of D. arecae as a pathogen on palm trees and other hosts are also discussed. This study illustrates that species in Diaporthe are highly overestimated, and highlights the relevance of applying an integrative taxonomic approach to accurately circumscribe the species boundaries in the genus Diaporthe.
Fertility Indicators for Porphyry-Cu-Au+Pd±Pt Deposits: Evidence from Skouries, Chalkidiki Peninsula, Greece, and Comparison with Worldwide Mineralizations
Authors: Economou-Eliopoulos Maria , Zaccarini Federica , Garuti Giorgio
Published: November 2023

The research interest for many authors has been focused on the origin, recovery, and exploration of critical metals, including platinum-group elements (PGEs), with the aim of finding new potential sources. Many giant porphyry Cu deposits are well known around the Pacific Rim, in the Balkan–Carpathian system, Himalayas, China, and Malaysia. However, only certain porphyry Cu-Au deposits are characterized by the presence of significant Pd and Pt contents (up to 20 ppm). This contribution provides new analytical data on porphyry-Cu-Au±Pd±Pt deposits from the Chalkidiki Peninsula and an overview of the existing geochemical characteristics of selected porphyry-Cu deposits worldwide in order to define significant differences between PGE-fertile and PGE-poor porphyry-Cu intrusions. The larger Mg, Cr, Ni, Co, and Re contents and smaller LILE elements (Ba and Sr) in fertile porphyry-Cu-Au-(PGE) reflect the larger contribution from the mantle to the parent magmas. In contrast, the smaller Mg, Cr, Ni, Co, and Re contents and larger Ba and Sr in PGE-poor porphyry-Cu-Mo deposits from the Chalkidiki Peninsula (Vathi, Pontokerasia, and Gerakario) and Russia–Mongolia suggest the presence of parent magmas with a more crustal contribution. Although there is an overlap in the plots of those elements, probably due to the evolution of the ore-forming system, consideration of the maximum contents of Mg, Cr, Ni, and Co is proposed. Magnetite which separated from the mineralized Skouries porphyry of Greece showed small negative Eu anomalies (Eu/Eu* ≥ 0.55), reflecting a relatively high oxidation state during the cooling of the ore-forming system. The relatively high, up to 6 ppm (Pd+Pt), and low Cr content towards the transition from the porphyry to epithermal environment, coupled with the occurrence of Pd, Te, and Se minerals (merenskyite, clausthalite), and tetrahedrite–tennantite in fertile porphyry Cu deposits (Elatsite deposit, Bulgaria), reflect a highly fractionated ore-forming system. Thus, in addition to the crustal and mantle recycling, metasomatism, high oxidation state, and abundant magmatic water, other factors required for the origin of fertile porphyry-Cu deposits are the critical degree of mantle melting to release Pt and Pd in the ore-forming fluids and the degree of fractionation, as reflected in the mineral chemistry and geochemical data.
Occurrence Characteristics of Lead–Zinc Mine and Low-Flying Aeromagnetic Prospecting in a Forested Region of Yichun City
Authors: Ji Naixuan , Qin Xiaoxiao , Wu Heyu , Wang Zi , Du Wei , Liu Yun , Zhang Tiehan , Zhang Shengze , Shi Qiaomu
Published: November 2023

Understanding the characteristics of lead–zinc mine occurrences and mastering effective investigative techniques are paramount in modern ore prospecting. This research focuses on the forested region of Yichun city in China, with a specific emphasis on the strategic mineral resource of a lead–zinc mine. The study examines the distribution patterns of this mineral and employs advanced aeromagnetic exploration methods. Firstly, we analyzed the geological structure and features of the region by leveraging the latest high-precision aeromagnetic data collected using dynamic delta wing technology. This analysis was complemented by an assessment of the geological conditions of the research area, existing lead–zinc deposits, ground magnetic surveys, and verification studies. With the goal of establishing a meaningful correlation between aeromagnetic anomalies and lead–zinc deposits, we employed various potential field conversion techniques, including the reduction to the pole, vertical derivatives, upward continuation, and residual anomaly analysis techniques. Secondly, we investigated the metallogenic sites within this region and provided a comprehensive summary of the metallogenic circumstances and characteristics related to aeromagnetic prospecting. Thirdly, we employed human–computer interaction fitting inversion techniques to predict the potential for lead–zinc mine prospecting in areas exhibiting aeromagnetic anomalies. The study underscores the significance of high-amplitude and large-scale aeromagnetic anomalies in the study area. Furthermore, we examined the interplay between intrusive rocks, strata, and structural elements within the region to identify favorable conditions for lead–zinc mineralization. As a result of our analysis and discussions, a location was predicted where a lead–zinc mine may exist. The research methodology outlined in this article provides valuable insights for future lead–zinc mine exploration efforts in areas characterized by similar geological conditions.
Tree Species Influence Nitrate and Nitrous Oxide Production in Forested Riparian Soils
Authors: Kelly Charlene N. , Matejczyk Elizabeth A. , Fox-Fogle Emma G. , Hubbart Jason A. , Driscoll Timothy P.
Published: November 2023

Abundance of soil microbial nitrogen (N) cycling genes responsible for nitrification, denitrification, and nitrous oxide reduction may vary with tree species and N inputs, and these variables may be used to predict or mediate nitrate (NO3−) and nitrous oxide (N2O) from soil. Nitrification and denitrification rates have also been linked to tree mycorrhizal associations, as soil beneath species associated with arbuscular mycorrhiza (AM) shows greater nitrification rates than species forming ectomycorrhizal (ECM) associations. In this study, we integrated N microbial functional gene abundance in the soil influenced by six tree species in two sub-catchments receiving either high or low N inputs. The soils beneath the two ECM-associated tree species and the four AM-associated tree species were analyzed for inorganic N content and potential N2O flux and microbial gene abundance (nirK and nosZ) was quantified using qPCR techniques. Other parameters measured include soil pH, moisture, and organic matter. We determined that tree species influence NO3− and N2O production in riparian soils, particularly under high N enrichment. The soil beneath black cherry had the lowest pH, NO3− concentration, potential N2O production, and OM, though this result did not occur in the low N catchment. The strongest predictors of soil NO3− and N2O across the study sites were N enrichment and pH, respectively. These results provide a framework for species selection in managed riparian zones to minimize NO3− and N2O production and improve riparian function.
Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review
Authors: Fardous Ali M. , Heydari Ahmad R.
Published: November 2023

This review delves into the intricate relationship between excess folate (vitamin B9) intake, especially its synthetic form, namely, folic acid, and its implications on health and disease. While folate plays a pivotal role in the one-carbon cycle, which is essential for DNA synthesis, repair, and methylation, concerns arise about its excessive intake. The literature underscores potential deleterious effects, such as an increased risk of carcinogenesis; disruption in DNA methylation; and impacts on embryogenesis, pregnancy outcomes, neurodevelopment, and disease risk. Notably, these consequences stretch beyond the immediate effects, potentially influencing future generations through epigenetic reprogramming. The molecular mechanisms underlying these effects were examined, including altered one-carbon metabolism, the accumulation of unmetabolized folic acid, vitamin-B12-dependent mechanisms, altered methylation patterns, and interactions with critical receptors and signaling pathways. Furthermore, differences in the effects and mechanisms mediated by folic acid compared with natural folate are highlighted. Given the widespread folic acid supplementation, it is imperative to further research its optimal intake levels and the molecular pathways impacted by its excessive intake, ensuring the health and well-being of the global population.
The Relationship between Vegetarian Diet and Sports Performance: A Systematic Review
Authors: Hernández-Lougedo Juan , Maté-Muñoz José Luis , García-Fernández Pablo , Úbeda-D’Ocasar Edurne , Hervás-Pérez Juan Pablo , Pedauyé-Rueda Blanca
Published: November 2023

Introduction: In recent years, the vegetarian diet has increased in popularity among athletes. The aim of this review is to ascertain the differences in variables related to performance, nutritional intake, and health in athletes according to whether they are omnivores or vegetarians. Methodology: A literature search was carried out in different databases: PubMed, Web of Science, Dialnet, and Cochrane. The keywords used were “vegetarian diet”, “vegan diet”, “exercise”, “sport”, and “performance”. After applying different inclusion criteria, six studies were included in the review. Results: No significant differences were obtained in variables related to physical performance (adherence exercise, Vo2Máx, muscle power, and sprint test) or health (body composition, psychological well-being, and social relationships), but dietary intake was significantly higher in carbohydrates and lower in proteins in vegetarian athletes (p < 0.05). Conclusions: It cannot be affirmed that vegetarian subjects have a higher sports performance, for which more research should be carried out.
Participation of Single-Nucleotide Variants in IFNAR1 and IFNAR2 in the Immune Response against SARS-CoV-2 Infection: A Systematic Review
Authors: López-Bielma María Fernanda , Falfán-Valencia Ramcés , Abarca-Rojano Edgar , Pérez-Rubio Gloria
Published: November 2023

Host genetic factors significantly influence susceptibility to SARS-CoV-2 infection and COVID-19 severity. Among these genetic factors are single-nucleotide variants (SNVs). IFNAR2 and IFNAR1 genes have been associated with severe COVID-19 in populations from the United Kingdom, Africa, and Latin America. IFNAR1 and IFNAR2 are subunits forming the type I interferon receptor (IFNAR). SNVs in the IFNAR genes impact protein function, affecting antiviral response and disease phenotypes. This systematic review aimed to describe IFNAR1 and IFNAR2 variants associated with COVID-19 susceptibility and severity. Accordingly, the current review focused on IFNAR1 and IFNAR2 studies published between January 2021 and February 2023, utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol. The electronic search was conducted in PubMed databases using Boolean operators and inclusion and exclusion criteria. Of the 170 literature pieces, 11 studies were included. We include case reports of rare SNVs, defined by minor allele frequency (MAF) < 1%, and genome-wide associated studies (GWAS). Variants in IFNAR1 and IFNAR2 could potentially be new targets for therapies that limit the infection and the resulting inflammation by SARS-CoV-2 infection.
Role of T Cells in Microbial Pathogenesis
Authors: Wang Liqing , Song Jianxun
Published: November 2023

The immune system functions as a sophisticated defense mechanism, shielding the body from harmful pathogenic invaders [...]
Chitosan Nanoparticles for Enhanced Delivery of Sida cordifolia Extract: Formulation, Optimization and Bioactivity Assessment
Authors: Alam Perwez , Imran Mohd , Ahmed Shahnawaz , Majid Haya , Akhtar Ali
Published: November 2023

In a continuous search for an essential antidiabetic agent, Sida cordifolia hydroalcoholic (SCHA) extract-loaded chitosan nanoparticles (SCHA-CS-NP) were optimized. The Box–Behnken design (BBD Design-Expert software, version 14) with three parameters was used to optimize the nanoparticles after creating them using the ion gelation method. The chitosan and Tween 20 contents and the stirring speed were chosen as the independent variables, and their separate and combined effects on particle size (Y1), polydispersity index (Y2) and entrapment efficiency (Y3) were observed. The optimized formulation showed a particle size of 51 nm, an entrapment efficiency of 84.54% and a polydispersity index of 0.391. Physicochemical characterization, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), a drug release study, an ex vivo permeation study, and an antioxidant study were performed. Confocal laser scanning microscopy (CLSM) images demonstrated that chitosan nanoparticles loaded with rhodamine B-laden SCHA extract had superior penetration compared to the control (rhodamine B solution). Furthermore, compared to conventional ascorbic acid (IC50 = 45 µg/mL), a superior antioxidant activity was discovered for SCHA-CS-NPs (IC50 = 86.45 ± 2.24 µg/mL), while SCHA-CS-NPs also exhibited strong antidiabetic potential (IC50 = 93.71 ± 1.79 µg/mL) compared to standard acarbose (IC50 = 97.25 ± 1.43 µg/mL). The overall results demonstrated that SCHA-CS-NPs are a promising and efficient formulation for oral delivery.
Factors Influencing the Implementation of a New Pharmacist Prescribing Service in Community Pharmacies
Authors: Amador-Fernández Noelia , Matthey-de-l’Endroit Julie , Berger Jérôme
Published: November 2023

The pharmacist prescribing service was legally permitted in 2019 in Switzerland to face challenges in the health system; however, there has been a lack of implementation. The aims of this study were to identify implementation factors and to evaluate pharmacy association interventions that aim to support implementation. A qualitative study with two methods was carried out: (1) twelve semi-structured interviews with community pharmacists were recorded, transcribed, and a thematic analysis was carried out using the Consolidated Framework of Implementation Research (CFIR); (2) questionnaires were submitted to the six pharmacy associations of French-speaking Switzerland. The main barriers found were non-reimbursement by health insurance companies, medications’ lack of clinical relevance, a negative perception of GPs, and a lack of time. The main facilitators were the availability of service information, pharmacies belonging to chains/groups, a reduction in the medical consultation burden, and the accessibility of pharmacies. Five associations answered, revealing different initiatives supporting implementation, but none of them had strategies at the political level nor communication strategies aimed at patients or GPs. Based on the CFIR, the most frequent implementation factors were highlighted, and this classification facilitates the transposition of the results to other contexts. The results will allow the development of targeted strategies and add the role of the pharmacy associations, which should be considered in future studies.
Odd Magneto-Optical Linear Dichroism in a Magnetophotonic Crystal
Authors: Mikhailova Tatiana V. , Ignatyeva Daria O. , Lyashko Sergey D. , Berzhansky Vladimir N. , Belotelov Vladimir I.
Published: November 2023

The phenomena of magneto-optical polarization rotation and circular magnetic dichroism are well known in the Faraday configuration. We present another effect, an odd magneto-optical linear dichroism, arising in nanostructures with polarization-dependent mode Q-factors and magneto-optical components. It reveals itself as the magneto-optical modulation of light intensity for the two opposite magnetization directions in the Faraday configuration. The effect was demonstrated on a magnetophotonic crystal with a cavity mode, the polarization-dependent Q-factor of which is due to oblique incidence. For a polarization angle of 60° (or 120°) and an angle of incidence around 60°, the magneto-optical intensity modulation maximizes and reaches 6%.
Bioactivity of Fractions and Pure Compounds from Jatropha cordata (Ortega) Müll. Arg. Bark Extracts
Authors: Jiménez-Nevárez Yazmín B. , Montes-Avila Julio , Angulo-Escalante Miguel Angel , Nolasco-Quintana Ninfa Yaret , González Christen Judith , Hurtado-Díaz Israel , Quintana-Obregón Eber Addí , Heredia J. Basilio , Valdez-Torres José Benigno , Alvarez Laura
Published: November 2023

Medicines for chronic inflammation can cause gastric ulcers and hepatic and renal issues. An alternative treatment for chronic inflammation is that of natural bioactive compounds, which present low side effects. Extracts of Jatropha cordata (Ortega) Müll. Arg. have been evaluated for their cytotoxicity and anti-inflammatory activity; however, testing pure compounds would be of greater interest. Campesteryl palmitate, n-heptyl ferulate, palmitic acid, and a mixture of sterols, i.e., brassicasterol, campesterol, β-sitosterol, and stigmasterol, were obtained from an ethyl acetate extract from J. cordata (Ortega) Müll. Arg. bark using column chromatography. The toxicity and in vitro anti-inflammatory activities were evaluated using RAW 264.7 murine macrophage cells. None of the products assessed exhibited toxicity. The sterol mixture exhibited greater anti-inflammatory activity than the positive control, and nitric oxide (NO) inhibition percentages were 37.97% and 41.68% at 22.5 μg/mL and 30 μg/mL, respectively. In addition, n-heptyl ferulate decreased NO by 30.61% at 30 μg/mL, while campesteryl palmitate did not show anti-inflammatory activity greater than the positive control. The mixture and n-heptyl ferulate showed NO inhibition; hence, we may conclude that these compounds have anti-inflammatory potential. Additionally, further research and clinical trials are needed to fully explore the therapeutic potential of these bioactive compounds and their efficacy in treating chronic inflammation.
From Petri Dish to Field: Plant Tissue Culture and Genetic Engineering of Oats for Improved Agricultural Outcomes
Authors: Pathi Krishna Mohan , Sprink Thorben
Published: November 2023

Oats (Avena sativa) hold immense economic and nutritional value as a versatile crop. They have long been recognized as an exceptional choice for human consumption and animal feed. Oats’ unique components, including proteins, starches, and β-glucans, have led to its widespread use in various food products such as bread, noodles, flakes, and milk. The popularity of oat milk as a vegan alternative to dairy milk has soared due to the increasing number of vegetarians/vegans and growing environmental awareness. Oat milk offers a sustainable option with reduced greenhouse gas emissions during its production, rendering it an appropriate choice for individuals who are lactose-intolerant or have dairy allergies. To ensure improved adaptability and enhanced nutrition, the development of new oat varieties is crucial, considering factors like cultivation, climate, and growing conditions. Plant cell culture plays a crucial role in both traditional and contemporary breeding methods. In classical breeding, plant cell culture facilitates the rapid production of double haploid plants, which can be employed to accelerate the breeding process. In modern breeding methods, it enables genetic manipulation and precise genome editing at the cellular level. This review delves into the importance of oats and their diverse applications, highlighting the advantages of plant cell culture in both classical and modern breeding methods. Specifically, it provides an overview of plant tissue culture, encompassing genetic transformation, haploid technology, protoplast technology, and genome editing.
Effect of Exogenous Calcium on Tolerance of Winter Wheat to Cold Stress during Stem Elongation Stage
Authors: Malko Maguje Masa , Peng Xinyue , Gao Xing , Cai Jian , Zhou Qin , Wang Xiao , Jiang Dong
Published: November 2023

Low-temperature stress during stem elongation is a major factor limiting wheat yield. While calcium (Ca2+) is known to enhance stress tolerance, it’s potential as an alternative to cold priming and the underlying mechanisms in wheat remains unclear. The current study assessed the effects of exogenous Ca2+ and calcium inhibitors on wheat growth and related physiology mechanisms under low-temperature stress. The results revealed that exogenous Ca2+ increased photosynthesis and antioxidant capacity, lowered cell membrane damage, and ultimately enhanced tolerance to low-temperature stress during the stem elongation stage, compared with the non-exogenous Ca2+ treatment. Moreover, exogenous Ca2+ induced endogenous Ca2+ content and triggered the upregulation of Ca2+ signaling and cold-responsive related genes. This study highlights the significance of exogenous Ca2+ in enhancing stress tolerance and contributing to wheat yield improvement under low-temperature stress.
Physiological, Cytological, and Transcriptomic Analysis of Magnesium Protoporphyrin IX Methyltransferase Mutant Reveal Complex Genetic Regulatory Network Linking Chlorophyll Synthesis and Chloroplast Development in Rice
Authors: Yao Youming , Zhang Hongyu , Guo Rong , Fan Jiangmin , Liu Siyi , Liao Jianglin , Huang Yingjin , Wang Zhaohai
Published: November 2023

Functional defects in key genes for chlorophyll synthesis usually cause abnormal chloroplast development, but the genetic regulatory network for these key genes in regulating chloroplast development is still unclear. Magnesium protoporphyrin IX methyltransferase (ChlM) is a key rate-limiting enzyme in the process of chlorophyll synthesis. Physiological analysis showed that the chlorophyll and carotenoid contents were significantly decreased in the chlm mutant. Transmission electron microscopy demonstrated that the chloroplasts of the chlm mutant were not well developed, with poor, loose, and indistinct thylakoid membranes. Hormone content analysis found that jasmonic acid, salicylic acid, and auxin accumulated in the mutant. A comparative transcriptome profiling identified 1534 differentially expressed genes (DEGs) between chlm and the wild type, including 876 up-regulated genes and 658 down-regulated genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that these DEGs were highly involved in chlorophyll metabolism, chloroplast development, and photosynthesis. Protein−protein interaction network analysis found that protein translation played an essential role in the ChlM gene-regulated process. Specifically, 62 and 6 DEGs were annotated to regulate chlorophyll and carotenoid metabolism, respectively; 278 DEGs were predicted to be involved in regulating chloroplast development; 59 DEGs were found to regulate hormone regulatory pathways; 192 DEGs were annotated to regulate signal pathways; and 49 DEGs were putatively identified as transcription factors. Dozens of these genes have been well studied and reported to play essential roles in chlorophyll accumulation or chloroplast development, providing direct evidence for the reliability of the role of the identified DEGs. These findings suggest that chlorophyll synthesis and chloroplast development are actively regulated by the ChlM gene. And it is suggested that hormones, signal pathways, and transcription regulation were all involved in these regulation processes. The accuracy of transcriptome data was validated by quantitative real-time PCR (qRT-PCR) analysis. This study reveals a complex genetic regulatory network of the ChlM gene regulating chlorophyll synthesis and chloroplast development. The ChlM gene’s role in retrograde signaling was discussed. Jasmonic acid, salicylic acid, or their derivatives in a certain unknown state were proposed as retrograde signaling molecules in one of the signaling pathways from the chloroplast to nucleus.
Pineapple Peel Flours: Drying Kinetics, Thermodynamic Properties, and Physicochemical Characterization
Authors: Reis Carolaine Gomes dos , Figueirêdo Rossana Maria Feitosa de , Queiroz Alexandre José de Melo , Paiva Yaroslávia Ferreira , Amadeu Lumara Tatiely Santos , Santos Francislaine Suelia dos , Ferreira João Paulo de Lima , Lima Thalis Leandro Bezerra de , Andrade Fabrícia Santos , Gomes Josivanda Palmeira , Silva Wilton Pereira da , Santos Dyego da Costa
Published: November 2023

Pineapple is a widely cultivated, consumed, and processed fruit by the industry. However, only 22.5% of the whole fruit is used, which constitutes economic waste and environmental impact. The objective was to determine the drying kinetics and characterize the residual peel flours of two pineapple varieties at four drying temperatures. Jupi and Pérola pineapple peels were dried at temperatures of 50, 60, 70, and 80 °C in a thin layer. Ten mathematical models were adjusted to the experimental data to characterize the drying process. Fresh samples and flours were characterized according to their physicochemical properties (water content, ash, water activity, total sugars, reducers, pH, acidity, proteins, lipids, carbohydrates, and total energy value—TEV). The Midilli model was chosen because it best represents the drying process with high values of determination coefficients (R2) and low mean squared deviations (MSD), Chi-square (χ2), and estimated mean error (EME). The increase in temperature led to an increase in the effective diffusivity coefficient and consequent reduction in drying time. The activation energy obtained from the Arrhenius equation was 24.59 and 26.25 kJ/mol for Jupi and Pérola, respectively. Differences were reported in the enthalpy and entropy decrease with the increasing temperature, contrary to the Gibbs free energy. The flours produced had good characteristics for conservation, being acidic with low water content and low water activity. High levels of total and reducing sugars, carbohydrates, and total energy value were observed, in addition to good protein content.
Study of Recent Deformations in the Bogotá Savanna and the City of Bogotá (Colombia) Using Multi-Temporal Satellite Radar Interferometry
Authors: Tamayo Duque Juan S. , Ruiz-Armenteros Antonio Miguel , Ávila Álvarez Guillermo E. , Matiz Gustavo , Sousa Joaquim J.
Published: November 2023

Bogotá, the largest urban center and capital city of Colombia, is located within the Bogotá savanna, which originated as a lake in the central part of the Colombian Eastern Cordillera. Over time, the lake transformed into a gently undulating plain with horizontally deposited sediments that formed around five million years ago. Over the last few decades, the region has undergone significant population growth and rapid urban development, largely driven by migration from rural areas. This development has substantially impacted the subsidence observed in the city, primarily due to the extraction of groundwater. A previous study by the Servicio Geológico Colombiano (SGC) utilized data from GNSS stations and synthetic aperture radar interferometry (InSAR) with TerraSAR-X SAR between 2011 and 2017 to identify a subsidence pattern in the central region of Bogotá. The purpose of the study was to evaluate the risks and potential disasters associated with the subsidence phenomenon. Our study investigates both the subsidence in Bogotá, previously studied, as well as the rural savanna area, which is currently undergoing significant residential and industrial development. We utilized multi-temporal InSAR (MT-InSAR) techniques with Sentinel-1 SAR images from 2014 to 2021. The analysis results indicate that the outer regions of the city display the most significant subsidence, extending from the center to the north. The subsidence velocities in these areas reach approximately 5–6 cm/year.