bluuebunny/crossref_metadata_2025 huggingface dataset:
Вирусный гепатит С: современные возможности диагностики (клиническая лекция)
Authors: Duda O.K. , Boiko V.O. , Ahafonkina I.M. , Yakovlieva A.V.
Published: January 2022

Рассмотрен вопрос современной диагностики вирусного гепатита С, что определяет тактику дальнейшего ведения и лечения таких больных. Представлены современные серологические и молекулярно-биологические методы обследования больного на вирусный гепатит С.
200 Years since the Greek Revolution: HUMANISTIC PHILHELLENISM and Its Main Characteristics in the Visual Arts (1821-2021)
Authors: Tsichla Dr Markella-Elpida
Published: January 2022

Philhellenism was a movement, its origins dating back to ancient times, that played a key role in the 19th century and the outbreak of the Greek Revolution in 1821. The contribution of military philhellenism to the liberation struggle of the Greeks is well known, but equally important was the humanitarian philhellenism, manifested in the arts, literature and science and influenced the public opinion of Europe and America, preparing the ground for the perception of this Struggle as a Sacred Struggle against oppression and barbarism. The images painted by famous and anonymous artists back then reflect the atmosphere of that time and the feeling that this uneven battle of the Greeks against the Ottoman Turks was a symbol of the fight against all barbaric behavior, such as oppression, lack of freedom, the rise of the slaveholders, and questioning religious faith. These are images that generally express the desire of European public opinion, in accordance with the teachings of the Enlightenment, to defend human rights with the necessary respect for secularism and ethnic origin. At the same time, the dominant spirit of the time highlights the connection between Greece and Antiquity, as classical culture had a great influence on the artists and intellectuals of the time. As a result, the images with reference to the Greek Revolution and its protagonists have many characteristics that take the form of symbols either of the conflict between different cultures with reference to religious differences or the connection of modern and classical Greece. Undoubtedly, the artistic movement of Romanticism played a key role to all this and Eugene Delacroix emerged as the embodiment of this perception.
Almidón resistente como prebiótico y sus beneficios en el organismo humano
Authors: Olayo-Contreras Victoria Montserrat , Alemán-Castillo San Juana , Rodríguez-Castillejos Guadalupe , Castillo-Ruiz Octelina
Published: January 2022

Los almidones resistentes están formados por dos polímeros, amilosa y amilopectina con capacidad de resistir la digestión y mantenerse intactos en el intestino; se han relacionado con la prevención y control de enfermedades como la obesidad, la diabetes mellitus, las enfermedades cardiovasculares y el cáncer. De acuerdo con diversas investigaciones, se determinó que el almidón resistente cumple con las características necesarias para ser catalogado como prebiótico. El consumo adecuado de estas fibras que se encuentran en los cereales, las leguminosas y los tubérculos, ayudarían a reducir las comorbilidades provocadas por las enfermedades antes mencionadas. El objetivo de este trabajo de revisión fue recopilar información sobre los beneficios del almidón resistente y su relación con la salud.
Working Analysis of Multistage Cloud Security Algorithms
Authors: Kumar Pradumn
Published: January 2022

Abstract: The security of Cloud computing has been a quickly developing administration which has numerous highlighted services over internet which reduces the cost and operating expenses. The greatest favorable position of cloud administrations is that one can work online in the cloud, whenever the term online comes it automatically concerns about data security. Cloud security gives better approaches for conveying security arrangements till now. In cloud storage we require security for the data so we will encrypt our data into cipher text before uploading and whenever we want access just decrypt cipher text with security policies. In this paper we are analyzing the symmetric encryption algorithm with asymmetric algorithm like DES, RSA and AES, IDEA, Blowfish etc to provide security to cloud data from attackers. By this encryption technique economically allows cloud access. Keywords: AES, 3DES, RSA, DES, BLOWFISH, IDEA, CRYPTOGRAPHY
Recent Overview on Synthesis of 2-Mercaptobenzimidazole Derivatives and its Activities
Authors: Devi Poonam , Shahnaz Mohammad , Prasad D.N.
Published: January 2022

A novel series 2-(1H-benzimidazol-2-ylsulfanyl) -N-(4-oxo-2-phenyl-thiazolidin-3yl) Various aldehydes and 2-acetamides have been used to synthesise -acetamide 5a–j (5-phenyl-[1,3,4]-oxadiazol-2-ylmethylsulfanyl) - 1H-benzimidazole 6a–j derived from a variety of benzoic acids. These compounds were tested in vitro for antibacterial activity against Gram positive bacteria Staphylococcus aureus and Enterococcus faecalis, Gram negative bacteria Klebsiella pneumoniae and Escherichia coli, and antifungal activity against Aspergillus fumigatus and Candida albicans. The in vitro cytotoxic properties of brine shrimp were investigated using a bioassay. Compounds 5b, 5d, 5g, 5i, 6b, 6e, 6f, and 6i demonstrated excellent activity against a panel of microorganisms, according to the results. 5b, 5g, 5i, 6b, 6f, 6h, and 6i were found to have good cytotoxic activities. Elements, IR, 1H-NMR, 13C-NMR, and MS were used to characterise all of the newly synthesised compounds.

Keywords: Antibacterial, Antifungal, 4-Thiazolidinone,1,3,4-Oxadiazole, Cytotoxicity.
Investigation of Proapoptotic Potential of Ipomoea carnea Leaf Extract on Breast Cancer Cell Line
Authors: Dubey Anubhav , Yadav Priyanka , Peeyush , , Verma Preeti , Kumar Roshan
Published: January 2022

Cancer remains to be a major global healthcare burden as 18.1 million new cases and 96 million death occurred 2018 on the basis of report from the international agency for research on cancer Breast cancer is the most common cancer diagnosed in women causing the highest morbidity. Ipomoea carnea leaf extracts have been used as a chemotherapeutic agent due to their antioxidant, anti-inflammatory, anti-bacterial, and anti-tumor effect. The aim of the study is to evaluate the proapoptotic potential of Ipomoea carnea leaf extract on breast cancer cell lines (MCF-7). The proapoptotic potential of Ipomoea carnea leaf extract was assessed using an MTT assay. The cell morphological changes in Ipomoea carnea leaf extract-treated cells were observed under a phase-contrast microscope. The proapoptotic effect of Ipomoea carnea leaf extract was examined using DAPI staining. The MTT assay results showed a significant reduction in the viability of breast cancer cells after treatment with different concentrations of Ipomoea carnea leaf extract (5-80 µg/ml) for 24h. We observed the inhibitory concentration at 20 μg/ml. Morphological changes such as reduction in the number of cells, cell shrinkage, and cytoplasmic membrane blebbing indicate the hallmark features of apoptosis were observed in Ipomoea carnea leaf extract-treated cells. DAPI staining results showed that apoptotic nuclei are stained intensely, fragmented, and have condensation chromatin in treated cells. Therefore it can be concluded that Ipomoea carnea leaf extracts have a pro-apoptotic potential in the breast cell cancer lines (MCF-7).

Keywords: Ipomoea carnea, Breast cancer, MCF-7, Apoptosis
In-silico ADMET profile of Ellagic Acid from Syzygium cumini: A Natural Biaryl Polyphenol with Therapeutic Potential to Overcome Diabetic Associated Vascular Complications
Authors: Ramya S. , Murugan M. , Krishnaveni K. , Sabitha M. , Kandeepan C. , Jayakumararaj R.
Published: January 2022

Plant Based Natural Products (PBNPs) are the primary source of natural antioxidants capable of neutralizing or eliminating harmful Reactive Oxygen Species (ROS). Oxidative stress contributes not only to the pathogenesis of type 2 diabetes (T2DM) but also to diabetic related vascular complications by lipid peroxidation. Oxidation induced DNA and protein damage leads to development of vascular complications like coronary heart disease, CVD, stroke, neuropathy, retinopathy, nephropathy, CKD, and other long term complications associated with diabetics. Likewise Multidrug resistance (MDR) is one of the major clinical challenges in cancer treatment and compromises the effectiveness of conventional anticancer chemotherapeutics. P-glycoprotein (P-gp) has been characterized as a major mechanism of MDR. Ellagic acid (EA) is a bioactive secondary metabolite widely distributed in vegetables and fruits (Strawberry, Grapes, Blackberry, Raspberry, Plums etc.) Chemically, EA is 2,3,7,8-tetrahydroxychromeno [5,4, -cde] chromene-5, 10-dione, a heterotetracyclic dimer of Gallic Acid (GA) molecules formed by oxidative aromatic coupling involving intramolecular lactonization. EA is associated with pharmacological activities such as anti-inflammatory, neuroprotective, cardio-protective, antioxidant, anti-mutagenic, multidrug resistance etc. EA has been marketed as a dietary supplement with claimed benefits against cancer, CVD, CKD and other metabolic disorders. However, pharmacological limitation of EA is attributed to its low solubility in water and reduced bioavailability. In the present study, bimolecular potential of EA has been bioprospected in the revised framework of ADMET pharmacoinformatics to further widen its biomedical applications.

Keywords: ADMET; Pharmacoinformatics; Ellagic Acid; Gallic Acid; Syzygium cumini; Alagarkovil Reserve Forest (ARF); Reactive Oxygen Species (ROS)
Antioxidant and Antidiabetic activity of hydroalcoholic flower extract of Woodfordia fruticosa (L.) Kurz
Authors: Giri Simran , Dey Ganesh , Dua Tarun Kumar
Published: January 2022

Woodfordia fruticosa (L.) Kurz, (W. fruticosa) a member of the Lythraceae family, commonly known as dhaiphul, has been used in traditional medicine to cure common illnesses since ancient times. The most effective part of this plant is the flower which has a high demand in the national as well as the international market of the eastern south part of Asian countries. The present study focuses on exploring the presence of phytochemicals, antioxidants, and antidiabetic potential of hydroalcoholic extract of flower of W. fruticosa. Phytochemical test showed the presence of saponin, flavonoid, carbohydrates, alkaloids, tannin, anthraquinone, and triterpenoids in the extract, and it showed an effective result of total phenolic content, total flavonoid Content with the value of 371.96 ± 2.86 mg of gallic acid equivalent per gram of the extract and 113.82 ± 0.178 mg of quercetin equivalent per gram of dry weight. In vitro antioxidant assay, for the DPPH assay, the IC50 values were found 30.85 ± 0.36 μg/ml and 22.35 ± 0.54 μg/ml for the extract of W. fruticosa flower and ascorbic acid respectively and for the FRAP Assay, the reducing power assay of plant extract is lesser than standard  (Ascorbic acid). W. fruticosa also showed significant hyperglycemic activity. In accordance with results, we can conclude that plant consists of a high polyphenolic and flavonoid group which help in antioxidant activity as well as the hydroalcoholic extract shows mild activity against diabetes.

Keywords: Woodfordia fruticosa, phytochemical, hydroalchoholic, antioxidants, antidiabetic, DPPH.
The Relationship between Antipsychotic Drug Use and Liver Enzyme Levels in People with Mental Disorders
Authors: Meiyanti Meiyanti , Mulia Lyfanni Fiesa , Pusparini Mulia,
Published: January 2022

The long-term use of some drugs causes side effects in the form of elevated liver enzyme levels. Meanwhile, antipsychotic drug therapy in people with mental disorders induces liver injury which leads to an elevation in serum glutamic oxaloacetic and pyruvic transaminases. Therefore, this study aims to analyze the relationship between the uses of antipsychotic drugs with elevated liver enzymes in people with mental disorders. This observational study used a cross-sectional design that included 69 people with mental disorders. The respondents were selected based on consecutive non-random sampling, while the data were collected using a questionnaire to obtain the universal characteristics of the subjects, therapy duration, and antipsychotic type, as well as an examination of AST and ALT levels using the ultraviolet test method. Furthermore, data analysis was conducted using the chi-Square test with a significance level of p<0.05. The results showed that thirty-two among the respondents or 46.4% used atypical antipsychotics, while 37 or 73.0% received the drugs for 1-6 months. In the subjects receiving typical antipsychotics, 10 or 55.6% had a significant elevation in liver enzymes compared to others receiving atypical antipsychotics namely 6 (18.8%) or a combination of both drugs namely 6 (31.6%). Therefore, the type of antipsychotic used in therapy has a significant relationship with elevated liver enzymes in people with mental disorders (p=0.028).

Keywords: antipsychotics, drugs, elevated
Analysis of animal models based on pre-clinical symptoms of gout
Authors: Singh Yogendra , Mishra Pankaj , Kannojia Pushpendra
Published: January 2022

Gout is a type of arthritis, which is a group of related disorders caused by episodes of abnormal inflammation in the joints. It is a metabolic disease characterized by high levels of uric acid in the blood. Uric acid is the end product of purine metabolism and hyperuricemia is caused by abnormalities of purine metabolism. Hyperuricemia is a risk factor for gout, heart disease, high blood pressure (hypertension), diabetes, and acute and chronic kidney disease. This research may attract widespread interest to researchers focusing on the different types of crystalline arthritis. There are over 100 types of arthritis. The most common forms are osteoarthritis (degenerative joint disease), rheumatoid arthritis, gout and pseudo-gout, septic arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, still's disease etc.

Many animal models are available to get rid of gout, mainly the hyperuricemia animal model, monosodium urate air pouch gout model, Intra-articular gout in rat, Paw edema, Gouty Arthritis Model, and Gouty nephropathy model. Various investigations have created a reliable and economical animal model for arthritis in a relatively short brief timeframe, manifested by long-term gross and behavioral abnormalities along with intra-articular monosodium urate deposition and tophi formation.

Lately years, hyperuricemia disease has gradually increased in the world. There are many updates that can be made by taking the arthritis model. If such a situation prevails, then in a few years, the patients of gout can increase in great quantity and there is some treatment for this disease. In any case, further review is really needed to focus on its particular pathogenesis and drugs.

Keywords: Gout, Arthritis, Gout Animal Model, Inflammation, Hyperuricemia, monosodium urate, crystalline arthritis.
Knowledge, Attitude and Practice of Testicular Self Examination among Male Undergraduate Students of University of Nigeria Enugu Campus
Authors: Ilo Ijeoma Judith , Omeye Oluchi Blessing , Ede Stephen Sunday , Chijioke Veronica , Okoh Chisom Favour
Published: January 2022

Background: Testicular cancer (TC) is the most common cancer in males between the age of 15 and 34 years with an incidence rates for new cases rising on an average of 0.8% each year over the last 10 years. Testicular self-examination (TSE) is the recommended preventive approach to reduce testicular Cancer (TC) mortality and morbidity.

Objectives: This study examines the knowledge, attitude and practice of TSE among male undergraduate students.

Methods: A descriptive research design with a sample of 343 students was recruited for the study. The students were stratified based on their faculties and convenient sampling was used to select the respondents. A self-structured questionnaire was used for data collection.

Result: The findings showed that more than average (57.7%) have heard about TSE, but the level of knowledge is poor, as only (35%) have good knowledge. Their attitude is poor as (83.8%) feels it is embarrassing to touch their scrotum. Due to the poor knowledge and attitude, the majority of the respondents 133 (69.43%) did not practice TSE. Of those 59 (30.7%) that practiced, only 20 (33.9%) respondents carried it out monthly as recommended. Chi-square analysis revealed a significant relationship between their knowledge of TSE and TSE practices (p = 0.006). Conclusion: This suggests that information should be provided to the public especially; young men through television, billboard, and other media on the need for regular TSE and TSE should be integrated into the secondary school curriculum.

Keywords: Testicular Self-Examination, Testicular Cancer, Nurses, Undergraduate, Enugu
Phytochemical and Antimicrobial Activity of Ocimum suave Against Selected Human Pathogenic Bacteria
Authors: Habyarimana Thierry , Cyuzuzo Parfait , Yamukujije Clémentine , Yadufashije Callixte , Niyonzima François N.
Published: January 2022

Worldwide, the use of antibiotics is losing effectiveness due to the substantial resistance to the antimicrobial developed by many pathogenic bacteria. African populations including Rwanda, use frequently traditional medicine for primary care. This study aimed to determine the phytochemicals and the antimicrobial activity of Ocimum. suave (O. suave) against selected human pathogenic bacteria (two strains of S. aureus, P. aeruginosa, two strains of E. coli, S. pneumonia, S. pyogene, K. oxytoca, H. influenza, S. sonei). The leaf and stem extracts were prepared using maceration technique. The antimicrobial activities of extracts were evaluated using the impregnated disc and agar well diffusion methods. The tests revealed the presence of phytochemical substances such as tannins, flavonoids, saponins, steroids alkaloids and phenolics in leaves and only saponins in stem. S. aureus ATCC 43300 was the most sensitive while H. influenza was the most resistant among the microorganisms tested. Aqueous and methanolic crude extract of O. suave displayed maximum diameter of inhibition zone against bacteria (9-26.5 mm and 9-23.5 respectively) and Two-way ANOVA showed statistical significance difference between their means. T-test was used in comparison with standards antibiotics and showed that the distilled water extracts exhibited much higher activity against all tested organisms than activity of streptomycin. Combination of distilled water and methanol extracts with streptomycin revealed synergistic activity against E. coli ATCC 25922 and S. pneumonia ATCC 49618. The leaves of O. suave have a great potential antibacterial activity and should be fully explored for future treatment.

Keywords: phytochemical; antimicrobial activity; Ocimum suave, Rwanda
Is There a Correspondence Between “Orientalism” and The Orient? – Said, Dyson and Sen
Authors: Gupta Amitabha
Published: January 2022

The study of cultural encounters has thrown up many important methodological and theoretical issues. Besides, these studies often rely on certain underlying socio-political and economic theories too. The objective of this paper is to unravel some of these issues and theories which underscore a very important area of cultural study, namely, the study of West’s cultural encounter of the Orient and the Western characterization of the Orient. Some of the cultural studies of this genre are obdurate and provocative, that is, the views of William Jones or Edward Said’s Orientalism. The paper (a) first states Said’s views. (b) then attempts to posit an alternative to Said’s Orientalism (i) implicit in Dyson’s book A Various Universe and (ii) inherent in the issues raised by Amartya Sen. The paper finally demonstrates that Said’s Orientalism is based on inappropriate methodological and theoretical assumptions and incongruous theories in the light of the studies outlined in (b).
Pecan plantation age influences the structures, ecological networks and functions of soil microbial communities
Authors: Liu Junping , Tang Yujie , Bao Jiashu , Wang Hankun , Peng Fangren , Chen Mengyun , Tan Pengpeng
Published: January 2022

Understanding the changes in microbial communities with increasing
plantation age will benefit the maintenance of forest health and
productivity and the sustainable development of forest ecosystems. Based
on MiSeq sequencing, we carried out the first study on the effects of
stand age on microbial communities in rhizosphere and bulk soils of
pecan plantation. The results suggested that soil bacterial alpha
diversity increased significantly with plantation age, while fungal
alpha diversity was less influenced. Bacterial and fungal biomarkers
differed by age group. The fungal community composition was
significantly altered by plantation age as reflected by the increase and
decrease in the relative abundances of Basidiomycetes and Ascomycota,
respectively. The pH and AP and TK contents drove microbial community
structure and composition. The bacterial network was more complex than
the fungal network, and simpler and more stable microbial network
structures occurred in the rhizosphere soil than in the bulk soil. With
increasing plantation age, the risk from plant pathogenic fungi
increased, and the functional profile of the microbial community shifted
from the nitrogen cycle to carbon utilization.
G6PD deficiency in Hansen’s disease: A preventable peril!
Authors: Ghorui Arnab , Patra Pratap
Published: January 2022

Although under-reported, hemolytic anemia is common with dapsone
therapy. However, it is prudent to screen underlying G6PD deficiency to
prevent potentially life-threatening episode of intravascular hemolysis
in leprosy.
The misplaced management of bees
Authors: Geslin Benoit , Ropars Lise , Zakardjian Marie , Flacher Floriane
Published: January 2022

Problem statement: To halt global biodiversity decline, many
conservation measures are set up by citizens, companies, or
stakeholders. However, even if originally well-intentioned, some of
these actions could have direct or indirect negative effects on
biodiversity when ecology is not accounted for. The management of bees
is a good example of such misplaced conservation practices. We
identified three successive errors in the management of bees which can
disrupt the focus on real conservation issues: the multiplication of
honey bee hives, the installation of insect hotels, the trade of
solitary bee cocoons for release into the wild. To help the bees, as
well as biodiversity in general, we must consider prioritizing efficient
conservation measures which consider more broadly the complexity of
ecosystems.
Optimal ambulatory vital sign targets in pulmonary hypertension pregnant women via time-dependent survival analysis
Authors: liu renhuai , zheng ziyu , su binxiao
Published: January 2022

Objective To investigate the safe range of vital signs of pregnant women
pulmonary hypertension (PH). Study design Retrospective study. Setting
The largest First-class Hospital at grade 3 in Northwestern China
Population pregnant women with PH in Intensive care unit (ICU). Methods
This of consecutive obstetric patients with PH admitted to ICU of the
First Affiliated Hospital of Air Force Military Medical University of
China, from January 2011 to May 2020, consisted of 92 cases analyzed
using time-dependent Cox regression to consider the dynamic features of
vital signs. Main outcome measures Maternal mortality Results 7/92
maternal deaths occurred. Three vital signs were identified as risk
factors in the maternal in-hospital mortality model via backward
selection: SpO2（HR，0.93；95%CI，0.88-0.97；P=0.003）, heart
rate（HR，0.94；95%CI，0.90-0.99；P=0.027）, and mean arterial pressure
(MAP) （HR，1.09；95%CI，1.00-1.18；P=0.045）. The optimal range of
SpO2 <73%, MAP was 65–95 mmHg, and heart rate was 59–125
beats per minute (bpm). Further exploration showed that the cumulative
and the longest consecutive time of abnormal vital signs also affect the
outcome. For example, SpO2<73% accumulated for 5 h or
continuously up to 2 h increases mortality. Conclusions: Maintaining
SpO2>73%, MAP at 65–95mmHg, and heart rate at 59–125 bpm
can significantly reduce in-hospital maternal mortality. The effects of
the abnormal SpO2, heart rate, and MAP on in-hospital maternal mortality
should be combined with the cumulative time and the longest duration.
Funding Dr. Binxiao Su is supported by the National Institutes of Health
(NIH) grant 81870961
Long-distance dispersal by a male sub-adult tiger in a human-dominated landscape
Authors: Hussain Zehidul , Ghaskadbi Pallavi , Panchbhai Pramod , Govekar Ravikiran , Nigam Parag , Habib Bilal
Published: January 2022

Conservation of wide-ranging species is a challenge owing to their
movement in an increasingly fragmented world. Long-distance dispersal
has significant implications for ecosystem functioning, and such
movement becomes challenging while navigating through a heterogeneous
and human-dominated landscape. Here, we describe one of the longest
dispersal journey by a sub-adult male tiger through GPS telemetry in
Central India. We analyzed movement metrics, directionality, and space
use during three behavioural stages of dispersal. We also used the
clustering method to identify resting and kill sites (n = 89). T1-C1
dispersed a straight-line distance of 315 km over 225 days, moving an
average 8.4 km/day and covering a cumulative displacement of~̵̴ 3000 km.
Movement during post-dispersal was higher (mean = 465.6 m/h) than those
during dispersal (mean = 376.6 m/h) and pre-dispersal (mean = 132.2
m/h), respectively. Moreover, movement during the night was
significantly faster than during the day in all three phases. Likewise,
during dispersal, the movement was faster (mean = 518.2 m/h) and more
directional (knight = 0.19) at night than day. The average size of
clusters was 1.68 ha and primarily away from human habitation (mean =
1875.6 m). The mean cluster duration (46.31 hr) was higher in the
non-forested area but was smaller in size than inside the forest
(p< 0.05). The individual crossed roads faster (mean= 1880.9
m/hr) than it travelled during other times. During the post-dispersal
phase, T1-C1 established its home range with an area of 319.48 sq. km.
(95% dBBMM). The dispersal event highlights the long-distance and
multiscale movement behaviour in a heterogeneous landscape. Moreover,
small forest patches play a key role in maintaining large carnivore
connectivity while dispersing through a human-dominated landscape. Our
study underlines how documenting the long-distance movement and
integrating it with modern technology can improve conservation
management decisions.
Adipocyte-Specific Modulation of KLF14 Expression in Mice Leads to Sex-Dependent Impacts on Adiposity and Lipid Metabolism
Authors: Yang Qianyi , Hinkle Jameson , Reed Jordan N. , Aherrahrou Redouane , Xu Zhiwen , Harris Thurl E. , Stephenson Erin J. , Musunuru Kiran , Keller Susanna R. , Civelek Mete
Published: January 2022

Genome-wide association studies identified single nucleotide polymorphisms on chromosome 7 upstream of KLF14 to be associated with metabolic syndrome traits and increased risk for type 2 diabetes (T2D). The associations were more significant in women than in men. The risk allele carriers expressed lower levels of the transcription factor KLF14 in adipose tissues than nonrisk allele carriers. To investigate how adipocyte KLF14 regulates metabolic traits in a sex-dependent manner, we characterized high-fat diet–fed male and female mice with adipocyte-specific Klf14 deletion or overexpression. Klf14 deletion resulted in increased fat mass in female mice and decreased fat mass in male mice. Female Klf14-deficient mice had overall smaller adipocytes in subcutaneous fat depots but larger adipocytes in parametrial depots, indicating a shift in lipid storage from subcutaneous to visceral fat depots. They had reduced metabolic rates and increased respiratory exchange ratios consistent with increased use of carbohydrates as an energy source. Fasting- and isoproterenol-induced adipocyte lipolysis was defective in female Klf14-deficient mice, and concomitantly, adipocyte triglycerides lipase mRNA levels were downregulated. Female Klf14-deficient mice cleared blood triglyceride and nonesterified fatty acid less efficiently than wild-type. Finally, adipocyte-specific overexpression of Klf14 resulted in lower total body fat in female but not male mice. Taken together, consistent with human studies, adipocyte KLF14 deficiency in female but not in male mice causes increased adiposity and redistribution of lipid storage from subcutaneous to visceral adipose tissues. Increasing KLF14 abundance in adipocytes of females with obesity and T2D may provide a novel treatment option to alleviate metabolic abnormalities.
Accessibility of islands: towards a new geography based on transportation modes and choices
Authors: Karampela Sofia , Kizos Thanasis , Spilanis Ioannis
Published: January 2022

Accessibility is a multifaceted concept that expresses the case of access between two points in space. For islands, accessibility is a key quality, since isolation and small size considered as inherent characteristics of “islandness”. In this paper, we discuss differences between geographical distance and accessibility potential in the Greek Aegean, combining different transportation modal choice (ferries and airplanes) with the use of an accessibility index that incorporates modes and frequency of connection and data of actual usage. The findings indicate that geographical distance is not determining accessibility and new geographies emerge based more on the availability of transport modal choices.
Development of a behavioural framework for analyzing employment mobility decisions in island areas: the case of the Aegean Islands, Greece
Authors: Kitrinou Eleni
Published: January 2022

This paper proposes a theoretical framework to model employment mobility in island areas. It aims at identifying the critical factors affecting the decision of the employees to relocate their workplace to an island area, given a possible residential relocation. Emphasis is given to the role of transport and telecommunications systems on the region’s connectivity and accessibility. Discrete choice models are developed, using both observed and latent variables for the workplace relocation decision to the Aegean island area in Greece. Data was collected in the year 2012 from 518 Greek employees. Findings indicate the importance of the role of transport and telecommunications systems for employment mobility in island areas. The estimated choice models identified profiles of the employees who are prone to: a) keep their current workplace; b) relocate their workplace to the island area; c) change occupation after residential relocation. Finally, the sample enumeration method integrates the models’ results across all Greek employees.
Changes In Intracranial Pressure in Patients with External Ventricular Drainage of CSF During Nursing Interventions
Authors: Črnila Nives
Published: January 2022

Introduction. When managing intracranial pressure (ICP)
disorders, that is, deviations from the normal value (5 - 15 mmHg), it helps to
understand the variability of cerebral blood volume and cerebrospinal fluid.

Aim. To explore from a series of cases the impact of nursing
interventions on the increase of intracranial pressure and the possibility of
preventive action on possible oscillations of measured pressure values by modifying
sedation and analgesia in order to avoid potentially negative effects on brain
injury.

Methods. The study included six patients, with the average
age of 59 years, hospitalized between December 2018 and May 2019, on whom
measurements were performed before, immediately after and 30 minutes after the
end of a particular intervention using an external drainage and monitoring
system. Intracranial pressures of patients in an induced coma were compared
with those who were in a natural coma.

Results. During morning nursing care and aspiration of
secretions, an increase in the mean value of ICP was observed immediately after
the intervention, but the t-test for dependent samples showed that it was not
statistically significant, while in massaging patients with turning it to the side
it was statistically significant. Combining all interventions into one, without
categorization, there was also a statistically significant increase in
intracranial pressure immediately upon completion of morning nursing care.
After 30 minutes, the pressure values in all interventions approach the initial
value and remain within the deviation of 1 mmHg.

Conclusion. Most nursing interventions are associated with a
slight increase in ICP that is not statistically significant. Greater
oscillations were observed in patients in an induced coma than in those in a
natural coma, which could probably have been avoided by even stricter titration
of analgosedation immediately before and during nursing interventions.
Health communication patterns of clean and healthy behavior in islamic Boarding School
Authors: Wahyudin Uud , Karimah Kismiyati El
Published: January 2022

The information received by Santries from various sources regarding infectious diseases in Pondok Pesantren’s environment is still confusing, which causes the Santries to be confused about finding reliable sources of information for their own health. They have sought this information through various sources. The purpose of this study is to determine who is the primary source of dissemination of health communication information related to Clean and Healthy Behavior and the health communication process within the Islamic boarding school in Sukabumi Regency, West Java, Indonesia. This study used a qualitative research method; then, the final results presented the health communication pattern among Islamic Boarding School in Sukabumi Regency. A case study approach was used in this study. The unavailability of updated, relevant data shows that the Central Government is still not actively moving towards the success of the PHBS Program at the national level in general and the education level of Islamic boarding schools in general. The difference between the provisions of the central government and the teachings of the Islamic religion that is applied in the Islamic Boarding School environment is one of the obstacles to implementing PHBS at the education level. The health information available in the mass media cannot be used by Santries to obtain information related to health. This research concludes that health information from Kyai’s teachings are the primary sources of health information in the Pesantren environment, supported by health information written in the Al- Quran and Al-Hadiths. Santries can receive health information outside the Pesantren environment through medical personnel, mass media, and information from the school. Suggestions from this research are  PHBS counseling for Kyai and Santries according to national health standards under the guidance and supervision of the Ministry of Health.
The Effect of Reciting the Holy Qur’an to the Speaking Ability and Spirituality Level of Stroke Patient with Motor Aphasia
Authors: Purnomo Slamet , Jenie Ikhlas Muhammad
Published: January 2022

Reading therapy is a stimulation effort to improve language function of a patient with motor aphasia. This study aim was to examine the effect of reading therapy using holy Qur’an to the speaking ability and spirituality level of stroke patient with aphasia. This experimental study used nonequivalent control group design with 20 persons as sample, divided to 10 persons as the intervention group and 10 persons in the control group used purposive sampling technique. Measurement of the speaking ability used Frenchay Aphasia Screening Test (FAST) questionnaire and spirituality level used Functional Assessment of Chronic Illness Therapy (FACIT) Sp 12 questionnaire. The Result was significant improvement of speaking ability in the intervention group with mean difference was mean±SD (1,60±1,075). Post-experimental difference test showed the difference of improvement of speaking ability between two groups, P=0,034. The spirituality level also significantly improved in the intervention group with mean difference was mean±SD (6,80±3,190). Post experimental difference test showed the improvement of spirituality level in both groups with P=0,005. This therapy can be used as a rehabilitation training activity independently at home to improve the speaking ability also as part of spiritual activity.
Symptom Burden’s Associated Factors among Hemodialysis Patients
Authors: Limbong Early Octavia , Pahria Tuti , Pratiwi Sri Hartati
Published: January 2022

Many patients with chronic kidney disease undergoing hemodialysis (CKD-HD) had a high symptom burden, which can worsen their health conditions and quality of life. The known factors associated to symptom burden were age, gender, hemodialysis (HD) session duration, post dialysis recovery time, hemoglobin level, nutrition status, physical activity, depression level and social support. The aim of this study was to analyze the most dominant factor associated to symptom burden among CKD-HD patients. Using a cross-sectional design, a convenience sample of eighty-five respondents were recruited from HD unit at Adventist Bandung Hospital, who underwent HD > 3 months, HD frequency 2-3 times a week, aged ≥ 18 years, able to communicate and speak Indonesian. Data were retrieved via seven self-reported questionnaires and health records, and the symptom burden was assessed using the validated Indonesian version of the CKD-Symptom Burden Index. The data was analysed with Spearman correlation test, Chi square test, and multivariate logistic regression. Based on quartile category, most of the respondents (50.6%) had a high symptom burden (33.56±12.23). The factors significantly associated to symptom burden were age (p=0.015), post-dialysis recovery time (p=0.007) and depression level (p=0.000). In the final model, duration of HD session (OR=5.27, 95% CI 1.50-18.49) and depression level (OR=8.84, 95% CI 2.57-30.36) were the factors associated to high symptom burden. Depression level was the most dominant factor associated to high symptom burden. CKD-HD patients with depression are more at risk of experiencing a high symptom burden. Thus, symptom management may consider to modify depression level factor by screening for depression, providing assistance and nursing interventions, or developing depression-related interventions to reduce symptom burden in CKD-HD patients.
The Effect of Using Simulation-based Learning on Nursing Performances of Early Postpartum Hemorrhage in Nursing Students
Authors: Pansuwan Kornkarn , Klankhajhon Sirikanok
Published: January 2022

Background: Early postpartum haemorrhage (PPH) is a crucial problem in maternal and newborn care. The simulation-based learning has an important role to improve knowledge, practical skills, and attitude in realistic case-based scenarios. This study aims to examine the effect on using simulated scenario in the simulation laboratory on nursing performance of early postpartum hemorrhage of nursing students.Methods: The quasi-experimental research, one group pretest-posttest design was used to study with the nursing students from the Faculty of Nursing, Naresuan University in Academic Year 2019 during the period of December 1, 2019 to January 31, 2020. The subjects of thirty nursing students were selected by purposive sampling. The instruments were the the ability in nursing of early postpartum hemorrhage through the questionnaires which consists of the performance test and satisfaction before and after the early PPH simulation program. The content of scenario consists of the definition, etiology, risk factors, signa and symptoms, treatment, holistic nursing care, and continuous care. The data were analysed as the descriptive: numbers, percentages, frequency, mean and standard deviation. The paired t-test was used to compare the outcome between pre-test and post-test.Results: The data were analysed by t-test. The results illustrated that the students who learned through simulated scenario on performance in nursing care of women with early postpartum hemorrhage had, after learning, higher performance in nursing care of women with early postpartum hemorrhage than that before learning at the .01 level of significance. The students were satisfied learning by using the simulation program in the high level (x̄ = 4.26, S.D. = 0.54).Conclusion: The simulation-based learning improves the core competencies and performances of nursing students for management women with early postpartum hemorrhage as knowledge, potential clinical care skills, and attitude. It will be useful to implement for nursing care women regarding early postpartum hemorrhage in the real situations.
Fear of Covid-19 Related Factors among Females in Indonesia: An Online Survey
Authors: Tumanggor Roxsana Devi , Imaroh Intan , Cashin Andrew
Published: January 2022

Background: The COVID-19 pandemic is a highly infectious ﬂu outbreakwhich spread rapidly around the world. COVID-19 outbreak caused panicand is predicted to increase the prevalence of mental illnesses suchas depression and anxiety disorder . Along with increased anxiety anddecreased mood, increased fear has been detected.Purpose: To analyze the fear of COVID-19 related factors and measure thelevel of fear among women in Indonesia.Methods: This is a cross-sectional study with 242 women who wasimplemented using the fear of COVID-19 instrument. A convenience samplewas utilized and was recruited via an online WhatsApp through personaltext to the potential respondents. The respondents stated their agreement toparticipate on the Google form before proceeding to fll in the data and answerthe instrument items. The analysis was carried out to obtain the frequencydistribution, mean and P-value. The mean score of each instrument item andthe overall items were calculated and compared based on demographic datausing t-test for two variables and analysis of variance (ANOVA) for three ormore variables. Furthermore, the scores obtained were categorized into lowand high fear levels based on the overall mean, where scores from 0-17were categorized as low-level fear and 18-35 as high-level fear.Results: The results showed that 90.9% of the respondents were withinthe age range of 15–25 years, with the majority being students. Based onthe results of statistical tests, it was discovered that question 3 (Q3) andquestion 4 (Q4) were the two items that aﬀected the level of women’s fearto COVID-19. Furthermore, the results of statistical tests using ANOVAshowed that occupation (P-Value of 0.01) and age (P-Value of 0.004) has asignifcant eﬀect on the fear of COVID-19. In addition, based on the overallscore calculation showed that 72.3% samples have high-level fear and 27.7%has low-level fear. Based on the results of this study, it was discovered thatwomen’s age and occupation inﬂuence the level of fear to COVID-19.Conclusion: This study highlighted the signifcance of pandemic relatedfear and can inform the development of future women’s health studies.
IMAGO IURIS EN LA ALLEGORIE VAN JUSTITIA MET DOODZONDEN cultura visual del Derecho: La pictura del sistema inquisitivo europeo durante el S. XVI
Authors: Calvo González José
Published: January 2022

El texto ofrece el análisis visual de óleo sobre tabla, Justitia Zeven Hoofdzonden, obra de de Antoon Claeissens (ca. 1536-1613), datada a 1584, confrontando otras versiones cmo son aguafuerte Iusticia, de Luca Penni (ca. 1500-1504-1556), realizado por Léon Davent, grabador del mediados del s. XVI, y el también óleo sobre tabla de Pieter Claeissens de Oude (ca. 1499-1576) que lleva por título Justitia overwint de zeven hoofdzonden (1570- 1613). El A. sostiene que la raigambre medieval de la temática de estas tres obras, relacionada con la alegoría de los siete pecados capitales, posee una dimensión jurídico conectada reformas procesales emprendidas por Francisco I de Francia (1494-1547) para la transición del sistema acusatorio al inquisitivo por la Ordonnance Villers-Cotterets (Ordonnance sur le fait de la Justice, 1539). En ese sentido, introduce nuevas referencias visuales, como la estampa Iusticia, de Pieter Bruegel de Oude (1525- 1569), grabada (1559) por Philips Galle (1537- 1612), y destaca elementos funcionales específicos acerca de desconocimiento del acusado de los cargos formulados en su contra, y la efectiva práctica de la diligencia probatoria de tortura (tortura judicial). Se remarca de esta manera la fuerza explicativa de la cultura visual del Derecho que, en efecto, se situará como una verdadera alternativa al conocimiento jurídico exclusivamente derivado de lo textual. Obras como Praxis rerum criminalium elegantissimis iconibus ad Materiam accommodatis illustrata (1554) y el Enchiridion Rerum Criminalium (1554), del holandés Joos de Damhouder (1507-1581), y Praxis criminis persequendi, elegantibus aliquot figuris illustrata (1541), de Jean de Milles de Souvigny (1490?-1563), emplean en abundancia el recurso a imágenes (xilografías) para retratar las formas de conducción y trato del acusado. Aislados esos rasgos el A. concluye en que la nueva imaginería jurídico-moral de la Justicia a que la introducción del sistema inquisitivo da lugar en Europa durante el s. XVI se encuentra dotada de una plástica inquietante. Este trabajo, pues, proyecta desde la perspectiva cultura visual del Derecho un innovador enfoque para estudio de problemas jurídicos y su mejor comprensión.
OKUL ÖNCESİ ÖĞRETMENLERİNE YÖNELİK ÖZEL YETENEKLİ ÇOCUKLARLA İLGİLİ HİZMET İÇİ EĞİTİM PROGRAMI ETKİLİLİĞİ
Authors: BAYRAM Sevinç , ŞENTÜRK Şener
Published: January 2022

Bu araştırmada, okul öncesi öğretmenlerine yönelik, özel yetenekli çocuklarla ilgili eğitim programının etkililiğini ortaya koymak amaçlanmıştır. Araştırmada ön test – son test kontrol gruplu deneysel desen kullanılmıştır. Araştırmada çalışma grubunu, resmi ve özel okul öncesi eğitim kurumlarında görev yapan 58 okul öncesi öğretmeni oluşturmuştur. Çalışma verileri “Katılımcılara İlişkin Kişisel Bilgiler Formu”, “Özel Yetenekliler Başarı Testi” ve “Program Sonu Değerlendirme Formu” aracılığıyla elde edilmiştir. Deney grubundaki okul öncesi öğretmenlerine 3 gün 18 saatten oluşan, araştırmacının hazırladığı özel yeteneklilere ilişkin bilgi ve farkındalık düzeyini artırmayı temel alan eğitim programı uygulanmıştır. Verilerin analizinde parametrik testlerden T- testi ve Anova kullanılmıştır. Araştırma sonunda deney grubu öğretmenlerin öntest-sontest puan ortalamaları arasında son test lehine; deney ve kontrol grubu sontest puan ortalamaları arasında deney grubu lehine anlamlı fark çıkmıştır. Ayrıca program sonu değerlendirme görüşlerine göre de eğitim programının etkili olduğu görülmüştür.