bluuebunny/crossref_metadata_2025 huggingface dataset:
Inhibitory Signaling to Ion Channels in Hippocampal Neurons Is Differentially Regulated by Alternative Macromolecular Complexes of RGS7
Authors: Ostrovskaya Olga I. , Orlandi Cesare , Fajardo-Serrano Ana , Young Samuel M. , Lujan Rafael , Martemyanov Kirill A.
Published: October 2018

The neuromodulatory effects of GABA on pyramidal neurons are mediated by GABABreceptors (GABABRs) that signal via a conserved G-protein-coupled pathway. Two prominent effectors regulated by GABABRs include G-protein inwardly rectifying K+(GIRK) and P/Q/N type voltage-gated Ca2+(CaV2) ion channels that control excitability and synaptic output of these neurons, respectively. Regulator of G-protein signaling 7 (RGS7) has been shown to control GABABeffects, yet the specificity of its impacts on effector channels and underlying molecular mechanisms is poorly understood. In this study, we show that hippocampal RGS7 forms two distinct complexes with alternative subunit configuration bound to either membrane protein R7BP (RGS7 binding protein) or orphan receptor GPR158. Quantitative biochemical experiments show that both complexes account for targeting nearly the entire pool of RGS7 to the plasma membrane. We analyzed the effect of genetic elimination in mice of both sexes and overexpression of various components of RGS7 complex by patch-clamp electrophysiology in cultured neurons and brain slices. We report that RGS7 prominently regulates GABABR signaling to CaV2, in addition to its known involvement in modulating GIRK. Strikingly, only complexes containing R7BP, but not GPR158, accelerated the kinetics of both GIRK and CaV2 modulation by GABABRs. In contrast, GPR158 overexpression exerted the opposite effect and inhibited RGS7-assisted temporal modulation of GIRK and CaV2 by GABA. Collectively, our data reveal mechanisms by which distinctly composed macromolecular complexes modulate the activity of key ion channels that mediate the inhibitory effects of GABA on hippocampal CA1 pyramidal neurons.

SIGNIFICANCE STATEMENTThis study identifies the contributions of distinct macromolecular complexes containing a major G-protein regulator to controlling key ion channel function in hippocampal neurons with implications for understanding molecular mechanisms underlying synaptic plasticity, learning, and memory.
Species-specific mechanisms of tumor suppression are fundamental drivers of vertebrate speciation: critical implications for the ‘war on cancer’
Authors: Nyce Jonathan W
Published: October 2018

We recently reported our detection of an anthropoid primate-specific, ‘kill switch’ tumor suppression system that reached its greatest expression in humans, but that is fully functional only during the first twenty-five years of life, corresponding to the primitive human lifespan that has characterized the majority of our species' existence. This tumor suppression system is based upon the kill switch being triggered in cells in which p53 has been inactivated; such kill switch consisting of a rapid, catastrophic increase in ROS caused by the induction of irreversible uncompetitive inhibition of glucose-6- phosphate dehydrogenase (G6PD), which requires high concentrations of both inhibitor (DHEA) and G6P substrate. While high concentrations of intracellular DHEA are readily available in primates from the importation and subsequent de-sulfation of circulating DHEAS into p53-affected cells, both an anthropoid primate-specific sequence motif (GAAT) in the glucose-6-phosphatase (G6PC) promoter, and primate-specific inactivation of de novo synthesis of vitamin C by deletion of gulonolactone oxidase (GLO) were required to enable accumulation of G6P to levels sufficient to enable irreversible uncompetitive inhibition of G6PD. Malignant transformation acts as a counterforce opposing vertebrate speciation, particularly increases in body size and lifespan that enable optimized exploitation of particular niches. Unique mechanisms of tumor suppression that evolved to enable niche exploitation distinguish vertebrate species, and prevent one vertebrate species from serving as a valid model system for another. This here-to-fore unrecognized element of speciation undermines decades of cancer research data, using murine species, which presumed universal mechanisms of tumor suppression, independent of species. Despite this setback, the potential for pharmacological reconstitution of the kill switch tumor suppression system that distinguishes our species suggests that ‘normalization’ of human cancer risk, from its current 40% to the 4% of virtually all other large, long-lived species, represents a realistic near-term goal.
How does chemotherapy treatment damage the prepubertal testis?
Authors: Allen Caroline M , Lopes Federica , Mitchell Rod T , Spears Norah
Published: October 2018

Chemotherapy treatment is a mainstay of anticancer regimens, significantly contributing to the recent increase in childhood cancer survival rates. Conventional cancer therapy targets not only malignant but also healthy cells resulting in side effects including infertility. For prepubertal boys, there are currently no fertility preservation strategies in use, although several potential methods are under investigation. Most of the current knowledge in relation to prepubertal gonadotoxicity has been deduced from adult studies; however, the prepubertal testis is relatively quiescent in comparison to the adult. This review provides an overview of research to date in humans and animals describing chemotherapy-induced prepubertal gonadotoxicity, focusing on direct gonadal damage. Testicular damage is dependent upon the agent, dosage, administration schedule and age/pubertal status at time of treatment. The chemotherapy agents investigated so far target the germ cell population activating apoptotic pathways and may also impair Sertoli cell function. Due to use of combined chemotherapy agents for patients, the impact of individual drugs is hard to define, however, use of in vivo and in vitro animal models can overcome this problem. Furthering our understanding of how chemotherapy agents target the prepubertal testis will provide clarity to patients on the gonadotoxicity of different drugs and aid in the development of cytoprotective agents.
Treupflichten beim grenzüberschreitenden Konsortialkredit
Authors: Renner Moritz
Published: October 2018

Welche ungeschriebenen Treupflichten bestehen zwischen den Mitgliedern eines Kreditgeber-Konsortiums? Wie vertragen sich derartige Treupflichten mit den im internationalen Konsortialkreditgeschäft üblichen Musterverträgen? Der Beitrag untersucht diese Fragen mit Blick auf das englische und das deutsche Recht. Er vertritt die These, dass für eine richterliche Vertragsergänzung durch ungeschriebe Treupflichten bei branchenweit akzeptierten Musterverträgen kein Raum bleibt.
ISOLATION, IDENTIFICATION AND SUBSTRATE SPECIFICITY OF A NITRILASE PRODUCING BACTERIA, Acidovorax sp. SK1
Authors: Koippully Soumya , Swaraj Pattnaik Subha , Busi Siddhardha
Published: October 2018

The process of biocatalysis or biotransformation remains the core of industrial biotechnology owing to its importance in the synthesis of high-value products in a cost effective manner. Nitrile biotransformation has also achieved considerable attention in last few decades due to its widespread biotechnological and industrial applications. In the present study, a versatile, potent nitrile-degrading bacterium, Acidovorax sp. SK1 was isolated from the cracker waste dumping site of Sivakasi, Tamilnadu and characterized for its biocatalytic potential, nitrilase production and enzyme activity. A pH sensitive indicator-based assay was performed to identify the nitrile degrading ability of the isolated samples. Semi quantitative High performance thin layer chromatographic (HPTLC) method was performed for quantitative measurement of mandelic acid produced from degradation of nitrile compound, mandelonitrile. The optimization of medium and nutritional parameters were studied for the improvement of nitrilase activity, which indicated that maximum nitrilase activity was observed at an optimum pH of 7.0, agitation at 100 rpm, glucose as best carbon source (10 g/L) and yeast extract (0.1 g/L) as principal nitrogen source. Biomass is also a critical parameter in the biocatalysis of mandelonitrile to mandelic acid and at a biomass of 100 mg/L, maximum nitrilase activity of 0.026 I.U was observed. The versatility of Acidovorax sp. in the hydrolysis of mandelonitrile to pharmaceutically valuable mandelic acid makes it a potential biocatalyst in organic synthesis. The present work demonstrates the production of nitrilase and the biotransformation of mandelonitrile to mandelic acid using the newly isolated strain of Acidovorax sp. SK1 and also suggests that this strain open avenues for biotechnological application as an effective green catalyst.
EFFECT OF ADDED RAPE HONEY ON CHOSEN PHYSICOCHEMICAL AND TEXTURAL PROPERTIES AND ANTIOXIDANT ACTIVITY OF YOGURTS DURING STORAGE
Authors: Remeňová Zuzana , Čanigová Margita , Kročko Miroslav , Ducková Viera
Published: October 2018

This study evaluated chosen physicochemical properties, antioxidant activity and textural properties of yogurts during refrigerated storage. The yogurts were divided into four groups as follows: control group without any additions of honey (K) and yogurts samples with the different addition 1, 3 and 5 % (w/v) of rape honey (A, B and C). These samples were analysed during fourteen days of storage at cooling temperature (6 ±1 °C). Yogurt samples were analyzed for dry matter content, fat content, pH values, lactic acid percentage, antioxidant activity and textural properties (firmness and cohesiveness). Dry matter content increased gradually with increased addition of honey. On the contrary, the rising addition of honey caused a decrease of fat content. The pH values of yogurt samples decreased during storage. The lowest firmness and cohesiveness was observed in the sample with highest addition of rape honey.
ANTIBACTERIAL ACTIVITY AND TOXICITY OF THE ETHANOLIC EXTRACT OF EUGENIA UNIFLORA L. LEAVES ON PSEUDOMONAS AERUGINOSA
Authors: J. Bobadilla Fernando , G. Novosak Marina , L. Winnik Daniana , V. Kachuk AnalÃ­a , E. Laczeski Margarita , I. Quiroga Marina
Published: October 2018

Pseudomonas aeruginosa is one of the main causes of nosocomial infections worldwide, with great potential for multi-resistance development. The World Health Organization (WHO) considers the antimicrobial resistance as an emerging public health problem that makes new therapies an extremely urgent issue. The aim of this work was to study the antibacterial capacity of the ethanolic extract of Eugenia uniflora L. leaves on Pseudomonas aeruginosa, its possible synergistic action with commercial antibiotics and to carry out general toxicity tests using the crustacean Artemia salina. The extract had a Minimum Inhibitory Dose (MID) of 0.5 mg.disc-1. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericide Concentration (MBC) for P. aeruginosa PAO1 were 1.33 mg.ml-1 and 13.33 mg.ml-1. For the clinical isolations were 0.83 mg.ml-1 and 8.33 mg.ml-1. The MBC/MIC ratio (MICI) qualified the action of the extract as bacteriostatic. The Time-killing curve showed that the total loss of viability of the bacteria occurs at 24 h to 16 mg.ml-1 and at 8 h to 32 mg.ml-1. The combination of meropenem with the extract results in a decrease in its inhibitory action on P. aeruginosa PAO1. Meanwhile, the combination with piperacycline or ceftazidime produces a synergistic action. For ciprofloxacin, amicacin and colistin the combination is indifferent. The LC50 obtained using A. salina was 0.61 mg.ml-1; indicating that the extract has a moderate toxicity. These results suggest that this species would be a potential source of antimicrobial agents to be applied in the treatment of infections caused by P. aeruginosa.
EFFECTS OF TWO ROOTSTOCKS (PISTACIA VERA L. AND PISTACIA ATLANTICA DESF.) ON THE YIELD, MORPHOLOGY, CHEMICAL COMPOSITION, AND FUNCTIONAL PROPERTIES OF TWO PISTACHIO VARIETIES (“MATEUR” AND “ACHOURY”)
Authors: Ouni Samiha , Chelli Chaabouni Azza , Noguera-Artiaga Luis , Hernández Francisca , Ben Hamda Hmida , Ouerghui Imen , A. Carbonell-Barrachina Ãngel , Rhouma Ali
Published: October 2018

The low diversification of rootstocks can be a problem in reducing the adaptation of pistachio to the Tunisian climatic and soil conditions. Nowadays, the most used rootstock is Pistacia vera; however, the autochthonous Pistacia atlantica could be a good alternative. The aim of this work was to study the effect of two different rootstocks Pistacia vera and Pistacia atlantica on the quality and functionality of two pistachio cultivars (the local variety “Mateur” and the Syrian one “Achoury”). The different parameters studied were: morphological (size, weight), chemical (minerals and fatty acids) and functional (total phenolic content, and antioxidant activity: ABTS+, DPPH•, and FRAP). The pistachios are a good source of minerals (especially Ca and K 19.9 and 9.8 g kg-1, respectively, and Fe 54.5 mg kg-1), polyunsaturated fatty acids (oleic and linoleic acids), and phenolic compounds (16.0 g GAE kg-1). The combination P. atlantica and variety “Mateur” led to proper values of tree yield, nut dehiscence, morphology (length and width), and oleic acid content. Thus, it can be concluded that the use of the local rootstock P. atlantica led to promising results and can be a good option due to its higher adaptation to the local climatic and soil conditions.
Charlemagne’s road, God’s threshing floor; comprehending the role of Hungary in the first crusade
Authors: Plumtree James
Published: October 2018

The violence that occurred in the medieval Kingdom of Hungary at the start of the First Crusade in the medieval Kingdom of Hungary appears in several of the works produced in the outpouring of literature that followed the capture of Jerusalem. Examination of these writings reveals ecclesiastic authors inserting exegesis, exempla, allusion, and aff abulation into their retellings. These inclusions countered criticism of those who fled, stressed communal Benedictine values, and crafted an understanding of the events and the new Crusade movement. Study of these depictions of the chaotic events in the semi-Christianized territory on the periphery of the Latin West reveals the development in presentation and reception of the crusade.
Ein moderner lügenbaron und sein biograf. über Mac Eck’s Sonderbare Reisen zwischen Konstantinopel und San Francisco (1901)
Authors: Hárs Endre
Published: October 2018

Der Wiener Feuilletonist Ludwig Hevesi (1843–1910) hat im Band Mac Eck’s Sonderbare Reisen zwischen Konstantinopel und San Francisco (1901) die Reiseerlebnisse des Wiener Fabrikanten und Privatgelehrten Friedrich Eckstein (1861–1939) veröffentlicht bzw. nacherzählt. Die Besonderheit der Sammlung besteht in der doppelten Autorschaft, die sich aus der Verquickung der narrativen Stimmen des mündlich berichtenden Eckstein und des protokollierenden Hevesi ergibt. „Mac Ecks“ Berichte über die USA dokumentieren den touristischen Erfahrungshorizont der Gründerzeit und die Auseinandersetzung Wiener Intellektueller mit dem Amerikanismus.
The body of history on Parallel Stories, the novel by Péter Nádas
Authors: Görözdi Judit
Published: October 2018

Péter Nádas’s novel published in the Hungarian language in 2005 deals with both European and Hungarian history, and validates a very specific view on history. The purpose of this paper is to reflect upon the question of relevance to the text concerning the body/body ideology aspects of Nádas’s historical approach. Differing representations of our sensuality in addition to placing the issue into a new context is one of the substantial undertakings of Parallel Stories, which in my opinion is worth approaching in the interrelationship of body – sensuality – body ideologies – history – power – novel structure. In my study, I start out from K. Theweleit’s theory, which combines the forceful exercise of power with the ideology of male camaraderie, I then analyse how this approach appears in different text levels, motifs, scenes of Nádas’s novel, up to the composition following the “chaos structure”.
Fascination with uniform? Choosing between military and civil careers in the eighteenth-century Habsburg Monarchy
Authors: Khavanova Olga
Published: October 2018

The article deals with the phenomenon of popularity of military service in the eighteenth-century Habsburg Monarchy. It exemplarily examines cases of entering and quitting the army in a wider context of belated career-start or switch in profession. Most typical models under scrutiny are disillusioned officers losing hope of promotion, ex-Jesuits who had joined the army to compensate the consequences of the dissolution of the Society of Jesus, retired army officers using the patronage networks to get admitted to the administrative elites, and retired Hungarian guardsmen who had chosen administrative career. The study is based primarily on ego documents, such as petitions and private letters, which are supplemented (where available) by the minutes and resolutions of respective administrative bodies. Successful, or unsuccessful, case-studies under scrutiny let describing society of the Habsburg Monarchy as horizontally mobile and highly motivated to reach social ascend through flexibility in the occupations-choice.
The impact of self-control cues on subsequent monetary risk-taking
Authors: Brevers Damien , Foucart Jennifer , Turel Ofir , Bertrand Anais , Alaerts Mikael , Verbanck Paul , Kornreich Charles , Bechara Antoine
Published: October 2018

Background and aims

The “process-model” of self-control proposes that the ego-depletion effect is better explained by a switch between interest in “have-to” labor and cognitive “want-to” leisure, rather than being mainly due to a decrease in cognitive resources, as advanced by the “strength-model” of self-control. However, it is currently difficult to disentangle the “process-model” from the “strength-model” of self-control. Here, we employed a stepwise approach, featuring three studies, for testing the process model of self-control.

Methods

In Study 1, we created a list of 30 self-control events for characterizing “have-to” conducts in the daily life. In Study 2, mental visualization of effortful self-control events (“have-to”) and monetary risk-taking (“want-to”) were employed for testing the strength-model of self-control. In Study 3, to test the process-model of self-control, participants were simply required to read self-control (or neutral) sentences.

Results

Study 1 provided evidence regarding external validly for the list of self-control events. Study 2 showed that mental visualization of effortful self-control events increases subsequent monetary risk-taking. Study 3 highlighted that the brief apparition of a self-control-related sentence was sufficient for increasing risk-taking. These patterns were evidenced in the trial with the less advantageous gain/loss ratio.

Discussion

Altogether these findings support the process-model of self-control in showing that triggering the semantic content of a “have-to” conduct, without its actual execution, is sufficient for modulating subsequent “want-to” activity.

Conclusion

These findings could contribute to advancing current knowledge on how the high availability of ready-to-consume rewards in modern environments is redefining humans’ self-control ability.
EKOLOJİK SİSTEMLER KURAMI ÇERÇEVESİNDE GÖÇMEN ÇOCUKLAR VE OYUNLARI ÜZERİNE BİR DERLEME
Authors: Eslek Duygu , Yılmaz Irmak Türkan
Published: October 2018

Göç kişinin çevresinde oluşturduğu değişimler nedeniyle
insan gelişimi için önem taşıyan bir olgudur. Bu derleme çalışmasında göç
olgusu Bronfenbrenner’ın Ekolojik Sistemler Kuramı’na göre değerlendirilmektedir.
Göç sonucu mikrosistem, mezosistem, ekzosistem ve makrosistemde değişimler
ortaya çıkar ve bu değişimlerle birlikte sistemler arası etkileşimler göçmen
çocuğun gelişimini bazen olumlu bazen de olumsuz etkilemektedir. Çocuk
gelişimini incelemek için önemli alanlardan biri de çocuk oyunlarıdır. Göç deneyiminin
çocuklar üzerindeki etkilerini ve çocukların göç deneyiminin oluşturduğu
değişimin yarattığı stres ile baş etme biçimlerini değerlendirmek için çocuk
oyunlarının incelenmesi önemlidir. Oyunlar, çocukların göç olgusuna açıklama getirmelerini
ve olay üzerinde kontrol sahibi hissederek kaygılarını azaltmalarını sağlar. Literatürde
göç deneyiminin çocuk gelişimi üzerindeki etkisini inceleyen çalışmalar sınırlı
olmakla birlikte göç sonrası çocuk gelişimini değerlendirmek amacıyla çocuk
oyunlarını inceleyen çalışmalar yok denecek kadar azdır. Bu derleme
çalışmasında göç eden çocukların oyunlarını inceleyen çalışmalar gözden
geçirilerek ilerideki araştırmalar için öneriler sunulmaktadır.
FÜZYONUNU TAMAMLAMAMIŞ BİR METOPİK SÜTÜR ÖRNEĞİ
Authors: GÖKSAL Nevin
Published: October 2018

İnsan beyni 45-50 yaşlarına kadar büyür ve dolayısıyla kafatasını genişletme ihtiyacı vardır. Kraniofasial kemiklerinin her biri komşuluk ettiği kemikle düz bir dikiş ile bağlanır. Kafatasında, parietal kemikleri birbirine bağlayan sütürler belli yaş aralıklarında kapanır. Bu çalışmanın temel amacı, Van ili civarında Babacan kırsalında yapılan kaçak kazılardan elde edilen 20-30 yaşında yetişkin bir kadın kafatasında tespit edilen metopik sütürün, ayrıntılı morfolojisini incelemektir. Ayrıca, metopik sütürün füzyonunu gerçekleştirememesinin olası nedenlerini ortaya koymakta bu çalışmayla mümkün olabilecektir. Metopik sütürün şekil boyut açısından dikiş desenini analiz etmek ve morfolojik karakterini belirlemek için makroskopik ve tomografik değerlendirmeler yapılmıştır. Metopik sütür, iki frontal kemiği gelişim aşamasında birleştirir. Bu iki kemik genellikle altı yaşında kapanır. Bazen metopik sütür erişkinlerde gözlenir ve kalıcı metopik sütür adını alır. Kalıcı metopik sütür; kranial kemiklerin anormal büyümesi, büyümenin durması, kalıtım, hormonal etki, atavizm, kraniyal malformasyonlar ve hidrosefali gibi çeşitli nedenlere bağlı olabilmektedir. Son yıllarda kafatası sütürlerinin çeşitleri, antropoloji ve adli tıp alanındaki önemi nedeniyle sıkça incelenmektedir. Metopizm kadınlar arasında erkeklerden daha sık görülmektedir ve ortalama yaşam süresinin düşük olduğu toplumlarda daha sık metopik sütüre rastlanılmaktadır. İncelenen bireyin ortalama yaşam süresinin düşük olması ve metopik sütür olgusuna kadın bireyde rastlanılması şimdiye kadar yapılan literatür sonuçlarını destekler niteliktedir. İncelemelerimiz sonucu, kafatasının genel morfolojik yapısındaki farklılık ve metopik sütürün füzyonunu tamamlayamaması bize bireyin gelişimsel bir hastalığa sahip olduğunu düşündürmektedir.
PALEOANTROPOLOJİ ALANINDA GÜNCEL GELİŞMELER
Authors: GÖKSAL Nevin , YILMAZ Hakan , ÖZBULUT Zehra
Published: October 2018

Son
yıllarda yapılan keşifler ve analizler atalarımızın evrimi hakkında şimdiye
kadar bildiğimiz her şeyin yanlış olabileceğini gösterir niteliktedir.
Çalışmamızda, 2015-2017 yılları arasında "Nature" ve
"Science" gibi önemli bilimsel dergilerde yayınlanan makaleler
derlenerek, insan evrimiyle ilgili yeni tarihlendirmeler, erken modern insan
kalıntıları üzerinde yapılmış analizler ve fosil primat kalıntılarından arkaik
insan türlerine kadar yeni teoriler ele alınmıştır. İnsan evriminde soyut
düşüncenin somut imgelere dönüştüğü mağara resimlerinden, ilk tarım
toplumlarının yeni tarihlendirmelerine kadar sunulmuş çalışmalar da göz önüne
alınmış ve değerlendirilmiştir. 
Australopithecus türlerinden erken Homo kalıntılarına, Neandertallerden
Denisovalılara, erken modern insandan modern insana kadar yayınlanmış makaleler
bir araya getirilmiştir. Bu çalışmanın paleoantropolojiyle uğraşan/ilgilenen
bilim insanları ve öğrenciler için de yararlı bir kaynak olabileceği
öngörülmüştür.
S1File_FullQuestionnaire v1
Authors: Englert Chris , Koroma Dennis , Bertrams Alex , Martarelli Corinna
Published: October 2018

The attention control video has been frequently applied to test the ego depletion effect. However, its validity has never been tested, a shortcoming we address in this preregistered study. In the first task, self-control strength was temporarily depleted in the depletion condition (n = 56) but remained intact in the control condition (n = 56). The attention control video served as the secondary task, and we assumed that the depletion condition would perform significantly worse compared to the control condition. Attention regulation was measured with an eye-tracking device. The results revealed that the gaze behavior in the two conditions differed statistically significantly; however, the actual difference was small, indicating that the attention control video may not be an optimal measure of self-control.
DAMPAK PERTUMBUHAN PENDUDUK TERHADAP PERKEMBANGAN RUANG KOTA SANGATTA
Authors: Subki Raksa Maulana
Published: October 2018

Kabupaten Kutai Timur sebagai daerah otonom yang juga menjadi salah satu wilayah penghasil batubara terbesar di Indonesia, menjadi daya tarik bagi para imigran untuk dapat bekerja di perusahaan-perusahaan tambang yang ada di wilayah Kota Sangatta dan sekitarnya, sehingga perkembangan kotanya sangat signifikan dikaitkan persentasi pertumbuhan penduduk yang mencapai 104,55% dalam 10 tahun terakhir. Perkembangan kotanya berkembang lebih cepat dari kebijakan-kebijakan yang dikeluarkan pemerintah daerah setempat, seperti RTRW dan RDTR, sehingga didalam perkembangannya kemudian banyak yang tidak sesuai dengan tata ruang wilayah maupun perencanaan kotanya. Banyak wilayah permukiman terbentuk namun tidak tertata dengan baik, karena dalam wilayah tersebut memiliki lebih dari 1 (satu) fungsi peruntukan yang masuk dalam kategori zona campuran. Dengan kondisi tersebut, maka diperlukan adanya langkah dan pemikiran dalam menyikapi permasalah-permasalah yang muncul sebagai sebuah solusi dalam menciptakan ruang kota yang lebih nyaman dan aman bagi masyarakat Kota Sangatta.
POLA PERMUKIMAN PESISIR PANTAI Studi Kasus: Desa Talaga 1 dan Desa Talaga 2 Kecamatan Talaga Raya Kabupaten Buton Tengah
Authors: Sarman Sufrin , Wijaya Karto
Published: October 2018

The pattern of fish settlements in this region is an island located in Southeast Sulawesi. This study aims to determine the environmental patterns of fishermen settlements in Talaga Kelurahan and Talaga two subdistricts Talaga Raya Central Buton District Southeast Sulawesi. Analysis of electricity village and village Talaga two subdistricts Talaga Raya Central Buton regency of Southeast Sulawesi, lift berdasar from the data in the settlement. Analytical techniques used are qualitative analysis and analysis and analysis of data source of settlement environment pattern in Talaga Satu and Talaga Dua Village, Talaga Raya Sub-district, Central Buton Regency of Southeast Sulawesi. Evacuation on islands and villages in Talaga village one and the condition of poles of fishermen settlement in the village in Talaga Village two.
PENGARUH MORFOLOGI KOTA TERHADAP EKOLOGI PERKAMPUNGAN TRADISIONAL DI KOTA BANDA ACEH, INDONESIA
Authors: Wulandari Elysa , Aulia Fahmi
Published: October 2018

Sejarah kota Banda Aceh berkembang dari kumpulan perkampungan tradisional yang unik secara ekologi, salah satunya Gampong Lamseupeung sebagai kampung tepi sungai. Ketika bencana tsunami 2004 merusak kota, kampung tersebut tidak terkena, tapi mengalami dampak ketika kota Banda Aceh dirancang kembali dengan pendekatan kebencanaan, yang mengembangkan infrastruktur jalan evakuasi melintasi beberapa perkampungan tradisional. Hal ini menyebabkan perubahan fisikal kampung tradisional, dan karakter masyarakat setempat. Tulisan ini mengkaji perubahan ekologi perkampungan tradisional tepi sungai sebagai akibat morfologi kota Banda Aceh. Kajian ini dianggap penting karena sejalan dengan Agenda pembangunan dunia tahun 2015 hingga 2030, melihat bagaimana pembangunan perkotaan yang inklusif, aman, berketahanan dan berkelanjutan, dan memperhatikan karakter masyarakat lokal. Pendekatan penelitian secara fenomenologi melihat rekam jejak perubahan fisik kampung dengan metoda kualitatif diskriptif, terkait dua hal, yaitu: i) aspek struktur lingkungan perkampungannya dan sumber daya kampung; ii) aspek dinamika kehidupan sosial budaya dan ekonomi masyarakat. Hasil penelitian tampak perubahan pola, orientasi dan pergeseran kepadatan kampung ke arah jalan arteri dan  perubahan masyarakat berkarakter urban. Hal ini memperlemah ikatan budaya pada lahan dan ikatan sosial budaya masyarakat. Kesimpulan penelitian menunjukkan, keberadaan perkampungan tradisional perlu dipertimbangkan dalam pembangunan kota modern untuk kota kecil-sedang. Pada dasarnya mereka yang membentuk karakter khusus suatu kota.
Synergetic Control System of Hybrid Power Plant
Authors: Kolesnikov A. A. , Kaliy S. D. , Radionov I. A. , Yakimenko O. I.
Published: October 2018

The problem of control of a hybrid power plant of a car consisting of an internal combustion engine, a synchronous electric motor with permanent magnets and a synchronous generator is considered. The formation of the control effect is carried out taking into account the connection of the above objects with each other with the help of planetary transmission. The mathematical models of the three listed engines are nonlinear with several control channels. In addition, the principle of the hybrid power plant requires the simultaneous operation of these engines and, accordingly, the construction of the necessary interrelated control actions. To synthesize the laws of vector control of a hybrid power plant, the method of analytical construction of aggregated regulators (ADAR) is used. Within the framework of this method, it is possible to work with a complete nonlinear control object model. Unlike the traditional approach of constructing a separate stabilizing control for each control channel, this method uses co-control over all variables to transfer the object to the desired state. In this case,for a number of variants of control algorithms, the communication between the control channels is carried out not indirectly, through the control object, but directly formed in the regulator. In addition, the control law takes into account unknown external disturbances, which were compensated using the principle of integral adaptation. In this paper, one of the modes of operation of a hybrid power plant is shown during the acceleration of the car. First, only the electric motor works, as the car accelerates, the internal combustion engine is connected, and at high speeds only the internal combustion engine works. This mode of operation of the hybrid power plant allows using both engines in the most convenient range of angular speeds, which leads to an economical fuel consumption and a charge of the storage batteries. In addition, the second electric motor operates in the generator mode and transfers a part of the mechanical moment to recharge the batteries.
Kinematic and Power Characteristics of the Active Frameless Aircraft Control Sidestick
Authors: Abdulin R. R. , Timofeev D. S. , Kravchenko A. A. , Krylov N. V. , Samsonovich S. L. , Rozhnin N. B. , Larin A. P. , Makarin M. A.
Published: October 2018

The article is devoted to the actual topic of a small-sized active aircraft control sidestick design and identification of parameters that influence its energy consumption characteristics. The analysis of structural regularities of active control sidestick kinematics design is carried out. The analysis demonstrates that the disadvantage of the known frame constructions, apart from the large dimensions, is the difference in the dynamic characteristics of the channels when using the same actuators, because the mass of a frame mounted actuator is the load for a fixed base mounted actuator. According to results of the analysis, a synthesis of the active control sidestick building based on using of kinematic pairs having one degree of motion was carried out. Hinged mechanisms were used that convert rotational motion of the input link (the actuator output shaft) to the swinging motion of the output link (the control sidestick handgrip) in a single plane. When using two such actuators, so that their links are located perpendicularly and connected to each other by a lever through one-degree-offreedom rotating pairs, a kinematic scheme with two degrees of motion is obtained. As a result the kinematic scheme of an active control sidestick which don’t use a frame is offered. The frameless scheme contains two identical actuators mounted on the fixed base, at that the interference of channels is excluded. The derivation of the actuator gear ratio between the rotation angle of the actuator output shaft and the handgrip deflection angle is given. It is shown that this dependence is of a sinusoidal type and that it is close to linear in the range of the handgrip operating angles. The given results of the parametric synthesis of the control sidestick electromechanical actuator allow to determine the electric motor minimum power and the gear ratio providing the required values of torque and speed at the actuator output link. In consequence of the research of the active control sidestick specific operation modes it is shown that the electric motor power depends on the required values of the maximum speed of the handgrip movement by a pilot and on the force applied to the handgrip, as well as on the handgrip inertia moment.
Factor Structure and Psychometric Properties of Perfectionism Inventory: Developing 3-Factor Version.
Authors: Garanyan N.G. , Kholmogorova A.B. , Yudeeva T.Y.
Published: October 2018

The paper presents the results of confirmatory factor analysis of the Perfectionism Inventory in the sample of 625 subjects (which included patients with affective spectrum disorders and healthy controls from the general population). Three factorial structure of the instrument has been identified: 1) perceived evaluations concerns along with unfavorable social comparisons; 2) high personal standards; 3) negative selectivity and imperfection concentration. The scales exhibit high internal con sistency. The results yield significant positive correlations between factors 1 and 3 and psychopathological symptoms (SCL-90-r). The Personal Standards subscale revealed no correlations with measures of psychopathological symptoms. Patients score higher on subscales 1 and 3 than the controls, whereas subscale 2 again didn’t show any differences. The results are discussed in the context of adaptive and maladaptive perfectionism dimensions.
The Generalized Problematic Internet Use Scale 3 Modified Version: Approbation and Validation on the Russian Sample
Authors: Gerasimova A.A. , Kholmogorova A.B.
Published: October 2018

The present study introduces the third version of the Generalized Problematic Internet Use Scale which takes into account the current tendencies in internet use and is based on the second revised version of the scale (GPIUS2, Caplan, 2010). The research was carried out online among Android OS users. The factor structure was verified on a sample of 204 persons (102 males and 102 females) aged from 14 to 21 years (M=17,34; SD=2). Convergent and intercorrelation validity was verified on samples of 1100 and 707 persons respectively, the majority of respondents were females. The factor structure of the scale was verified by means of confirmatory factor analysis. A relationship between problematic internet use with psychopathological symptoms and gender was found. Girls are more likely to prefer online communication and are more compulsive and cognitively preoccupied with life in the network compared to boys, but are less likely to use the network as a way of mood regulation. The overall results confirm that the scale is an adequate measure of problematic internet use among adolescents and young adults.
How Swiss primary students interpret a national monument
Authors: Mathis Christian , Gollin Kristine
Published: October 2018

Since historical monuments are often difficult to interpret, this study commences with the questions, how do students understand historical monuments and in what ways are they able to describe and interpret them? The focus of our paper is a monument showing Arnold Winkelried, a leading
Swiss national figure that nine Swiss students of Grades 5 and 6 studied. Winkelried is a legendary Swiss hero who sacrificed himself to bring about Swiss victory over the Austrian Habsburgs in the Battle of Sempach in 1386. As an iconic, symbolic source of Swiss national cultural heritage,
he is representative of the establishment of the young Swiss Federation's history culture in the second half of the nineteenth century. The study's mainly oral research data was collected by means of focus groups (Bohnsack, 2010). The discussions with the students were recorded, transcribed
and analysed using a documentary method (Straub, 1999), that is, we reconstructed typical patterns of description. The findings first indicated that students find it difficult to observe and describe such monuments appropriately. Indeed, the students tended to begin the process by guessing
what they were observing. Second, the findings show that through the interviewer's prompts – accurate observations and descriptions – during the focus group sessions, students can activate prior knowledge and thus engage with the historical topic.
El nacional-populismo y sus consecuencias en el orden internacional
Authors: Rayran Cortés Manuel Alejandro
Published: October 2018

El nacional-populismo ha irrumpido el escenario internacional de manera sorpresiva. Sus representantes políticos han conquistado cargos de suma importancia, desde los cuales han tratado de modificar el actual orden mundial. Los detractores del populismo hallan su causa en los pensamientos malsanos de sus dirigentes, mientras que otros lo encuentran en los déficits de la democracia y los cambios estructurales de los asuntos económicos y sociales. Es así que este artículo busca explicar las causas del actual fenómeno y sus consecuencias en el orden internacional, estudiando el caso de Estados Unidos con el actual presidente Donald Trump.
Las ampliaciones de la Unión Europea hacia Europa del este: impacto político, económico y social y nuevos nacionalismos
Authors: Rodríguez Suárez Pedro Manuel , López Ángel Gustavo
Published: October 2018

Este artículo analiza el impacto que ha tenido la membresía de la UE en los países de Europa del Este. Las ampliaciones de la UE hacia Europa del Este, han transformado radicalmente a los países ex socialistas europeos. Asimismo, han contribuido a terminar con el orden europeo que fue establecido en el viejo continente, después de la segunda guerra mundial. Por otro lado, este ensayo efectúa un estudio comparativo en relación con el crecimiento y el desarrollo económico entre los países de Europa del este que actualmente forman parte de la UE y los países de la “nueva Europa del este”, que no son miembros de dicha organización. Aunado a lo anterior, evalúa los “nuevos nacionalismos” y el auge de los partidos políticos de ultra derecha en Europa. Desde la perspectiva teórica, este artículo se sustenta con la teoría de la Seguridad Compleja que postula Barry Buzan y Ole Waever.
La política exterior dependiente: el caso de Ecuador
Authors: Lapeña Sanz Ramiro , Czubala Ostapiuk Marcin Roman
Published: October 2018

La política exterior dependiente es un concepto que define la relación de un Estado con otras naciones. Dicha correlación, traducida en una estrecha vinculación de su economía frente a uno o varios países, puede ser ocasionada de manera voluntaria o contra el deseo del Estado en cuestión, incidiendo así en su política exterior. Partiendo de este supuesto, el objetivo principal del presente trabajo es analizar el caso particular de Ecuador mediante un examen en profundidad de su relación con Estados Unidos de América (EE.UU.) y República Popular China. Igualmente, el marco temporal de este artículo está centrado en el período 2007-2016, cubriendo así el mandato del presidente Rafael Correa. Para ello, en primer lugar, se expone el marco teórico y el estado de la cuestión. Posteriormente, se estudian los intercambios económicos de Ecuador con Estados Unidos de América y República Popular China, poniendo un especial énfasis en las relaciones comerciales, la inversión extranjera directa, la deuda y la ayuda oficial al desarrollo. Por último, se presentan las conclusiones obtenidas.
Análise Comparativa De Conversores Monofásicos Aplicados À Correção De Fator De Potência
Authors: Beltrame Fernando , Roggia Leandro , Schuch Luciano , Renes Pinheiro José
Published: October 2018

Esse trabalho apresenta um estudo comparativo entre conversores monofásicos aplicados à correção de fator de potência. Os conversores sob análise são o conversor boost, o conversor boost intercalado, e o conversor dual boost. Tais conversores são utilizados como estágio de entrada em fontes de equipamentos da tecnologia da informação. Nesta análise todos os conversores utilizam os mesmos parâmetros de projeto, e foram projetados para apresentarem a mesma taxa de distorção harmônica da corrente de entrada com o intuito de utilizarem o mesmo filtro de entrada. O sistema de controle utilizado é baseado em uma lei de controle de corrente preditiva e um algoritmo para detectar o modo de condução, uma vez que os conversores operam em modo de condução mista. Os parâmetros analisados para a comparação das topologias são: fator de potência, taxa de distorção harmônica da corrente de entrada, perdas nos dispositivos semicondutores e magnéticos, volume dos dissipadores e materiais magnéticos, interferência eletromagnética conduzida, eficiência e custos.
Frequency-domain Analysis Of Resonant Current Controllers For Active Power Filters
Authors: Rodrigues Limongi Leonardo , Roiu Daniel , Bojoi Radu , Tenconi Alberto
Published: October 2018

This paper performs a frequency-domain analysis of three different resonant current controllers for active power filters. Respect to previous papers, the novelty consists of a stability analysis of the closed loop system using the Nyquist criterion. To perform this analysis, the time delay introduced by the inverter and the sampling due to the digital control are taken into account in the current controller closed loop transfer function. This procedure demonstrates the importance and effectiveness of the delay compensation to maintain the whole system stability. Experimental results are presented for a 25 kVA shunt active power filter prototype to confirm the theoretical analysis.
AVANTE: An architecture of CORBA components and XML Metadata for Web Based Instruction
Authors: Bianchini Adelaide , Theoktisto Victor , Ruckhaus Edna
Published: October 2018

Most current solutions for Web Based Instruction (WBI) use a centralized management model and a proprietary internal representation. The AVANTE Architecture is a WBI environment assembled using CORBA distributed components, implementing core services such as course management, user authentication, collaborative work, database access, presentation, and others. The AVANTE components conform to a 4-tiered model, with Client, Presentation, Management, and Low-Level Services component sublayers. Emergent XML standards for WBI describe all metadata definitions. Components at the Management layer manipulate JDBC-SQL data from the Low- Level Services Layer, and combine it with corresponding XML Schemas, instantiating course objects as new XML descriptions and component services. A filter-mapping service in the Presentation layer produces the dynamic HTML web pages needed for user interaction, processing these XML descriptions by applying one or more previously defined XSL stylesheets. A similar mechanism implements interface customization and remote service administration. The developed WBI system was deployed with open source software. Adding CORBA components easily achieves on-demand scalability. Future services include auditing, adaptive interfaces, grading, content development, and integration with existing systems.
A Fuzzy Model for Function Point Analysis to Development and Enhancement Project Assessments
Authors: Lima Júnior Osias de Souza , Muniz Farias Pedro Porfírio , Dias Belchior Arnaldo
Published: October 2018

Function Point Analysis (FPA) is among the most commonly used techniques to estimate the size of software system projects or software systems. During the point counting process that represents the dimension of a project or an application, each function is classified according to its relative functional complexity. Various studies already propose to extend FPA, mainly aimed at achieving greater precision in the point assessment of systems of greater algorithmic complexity. This work proposes the use of concepts and properties from fuzzy set theory to extend FPA to FFPA (Fuzzy Function Point Analysis). Fuzzy theory seeks to build a formal quantitative structure capable of emulating the imprecision of human knowledge. With the function points generated by FFPA, derived values such as costs and terms of development can be more precisely determined.
Diz artroskopisi ve inguinal herni cerrahisinde ünilateral ve bilateral spinal anestezi uygulamalarında QTc değişikliklerinin karşılaştırılması
Authors: TÜRK Fatoş İpek , ŞİMŞEK Tuncer , ERBAŞ Mesut
Published: October 2018

Amaç: Kardiyovasküler sistem üzerine etkileri ve düzeltilmiş QT değeri (QTc)
değişiklikleri açısından ünilateral ve bilateral spinal anestezi yöntemlerinin
hasta grupları üzerinde karşılaştırılması amaçlandı.

Gereç ve Yöntem:
Artroskopi ve inguinal herni cerrahilerinde
toplamda 40 hastaya rastgele geliş sırasına göre bilateral ve ünilateral spinal
anestezi uygulandı. Lokal anesteziğin intratekal olarak verilmesi sonrasındaki
1, 3, 5, ve 15. dakikalarda ve ardından cerrahi başladığından itibaren 1, 3, 5,
15.dk ve ardışık gelen 10 dakikalık sürelerde 30 saniye süren holter EKG kaydı
alındı. Hastaların hemodinamik parametreleri kaydedildi. Düzeltilmiş QT
değerleri hesaplandı. 

Bulgular: Kalp atım hızları 25. dakikada ve 35. dakikada bilateral spinal grupta
daha fazla olup gruplar karşılaştırıldığında anlamlı fark saptandı (p=0,046;
p=0,021). QTc değerlerinin, spinal anestezi ve cerrahi süre ölçümlerinde her
iki grupta da uzadığı görüldü. Bazzet’e göre QTc değerlerinin spinal
anestezinin 1., 3., 5. ve 15. dakikasında ve cerrahi süresinin 1., 3., 5., 15.,
25. ve 35. dakikasında bilateral grupta ünilateral gruba göre istatistiksel
anlamlı daha uzun olduğu tespit edildi (p<0,05). 

Sonuç: Ünilateral spinal anestezinin QTc uzamasına bağlı
kardiyovasküler komplikasyonları önleme açısından bilateral spinal anesteziye
göre daha üstün bir yöntem olduğu değerlendirilmektedir..
Posterior mediasten yerleşimli nörojenik tümörlerde spinal kanal invazyon insidansı ve cerrahi yaklaşımı
Authors: KANBUR METİN Serda , EVMAN Serdar
Published: October 2018

Amaç: Posterior mediastinal nörojenik tümörlerin yaklaşık %10’u spinal kanala
invazedir. İnvaze tümörlerin tek seansta güvenli bir şekilde spinal ve torasik
komponentinin birlikte çıkarılması gerekir. Bu lokalizasyondaki tümörlerin
spinal kanal invazyonunun olup olmadığının direkt ve indirekt bulguları,
ameliyat öncesi çektirilen bilgisayarlı tomografi (BT) ve manyetik rezonans
görüntülemesi (MRI) ile detaylı olarak değerlendirilmelidir. Çalışmamızda,
kliniğimizde opere ettiğimiz bu tür tümörlerdeki tanı ve yaklaşımımızın
sunulması amaçlanmıştır.Gereç ve Yöntem: Nörojenik tümör nedeni
ile opere ettiğimiz tüm hastaların klinik bilgileri retrospektif olarak analiz
edildi. Bulgular: Çalışmaya aldığımız 35 hastanın
19’u erkek 16’sı kadındı ve yaş ortalaması 40 yıldı (dağılım: 19-71). Hastaların
sadece 5’inde (%14) operasyon öncesi semptom mevcuttu. Tümör boyutları 2,1 cm ile 17 cm arasında (ortanca 6,2)
idi. Hastaların 7’sinde (%20) radyolojik olarak spinal kanal invazyonu olduğu
belirtildi. Laminektomi gerektiren dumbbell
tipteki 6 hasta ile birlikte hepsi komplet olarak rezeke edildi. İnvazyon
gösteren vakalardaki lezyonlar beyin ve sinir cerrahi uzmanı ile birlikte
yapıldı. Ortalama takip süresi 48 ay (3 ila 72 ay) idi. Bir hastada ameliyat
sırasında tamir edilen serebrospinal sıvı kaçağı ile postoperatif kalıcı
olmayan spinal hasar meydana geldi ve 4 ayda düzeldi. Mortalite gözlenmedi.

Sonuç: Ameliyat öncesinde, nörojenik dumbbell tümör teşhis edilmezse, sadece
intratorasik kısmının çıkarılması, kalıcı spinal hasara neden olabilir. Spinal kanalı
incelemek için MRI kritik öneme sahiptir. Preoperatif invazyon tespit
edildiğinde tek seansta sinir cerrahisi ekibi ile birlikte tümörün daha güvenli
rezeksiyonu mümkündür.