bluuebunny/crossref_metadata_2025 huggingface dataset:
Thoracic aortic aneurysm is an independent factor associated with diffuse idiopathic skeletal hyperostosis
Authors: Uehara M. , Takahashi J. , Ikegami S. , Kuraishi S. , Fukui D. , Imamura H. , Okada K. , Kato H.
Published: April 2018

Aims

Although we often encounter patients with an aortic aneurysm who also have diffuse idiopathic skeletal hyperostosis (DISH), there are no reports to date of an association between these two conditions and the pathogenesis of DISH remains unknown. This study therefore evaluated the prevalence of DISH in patients with a thoracic aortic aneurysm (AA).

Patients and Methods

The medical records of 298 patients who underwent CT scans for a diagnosis of an AA or following high-energy trauma were retrospectively examined. A total of 204 patients underwent surgery for an AA and 94 had a high-energy injury and formed the non-AA group. The prevalence of DISH was assessed on CT scans of the chest and abdomen and the relationship between DISH and AA by comparison between the AA and non-AA groups.

Results

The prevalence of DISH in the AA group (114/204; 55.9%) was higher than that in the non-AA group (31/94; 33.0%). On multivariate analysis, the factors of AA, male gender, and ageing were independent predictors of the existence of DISH, with odds ratios of 2.9, 1.9, and 1.03, respectively.

Conclusion

This study revealed that the prevalence of DISH is higher in patients with an AA than in those without an AA, and that the presence of an AA significantly influenced the prevalence of DISH. Cite this article: Bone Joint J 2018;100-B:617–21.
In defence of the posterior malleolus
Authors: White T. O.
Published: April 2018

The posterior malleolus of the ankle is the object of increasing attention, with considerable enthusiasm for CT scanning and surgical fixation, as expressed in a recent annotation in The Bone & Joint Journal. Undoubtedly, fractures with a large posterior malleolar fragment that allow posterior talar subluxation from the mortise are served better by fixation. However, in all other situations, the existing literature does not support this widespread change in practice. The available biomechanical evidence shows that the posterior malleolus has little part to play in the stability or contact stresses of the ankle joint. Radiographic studies have not shown that CT scanning offers helpful information on pathoanatomical classification, case selection, or prognosis, or that scanning improves the likelihood of an adequate surgical reduction. Clinical studies have not shown any improvement in patient outcome after surgical fixation, and have confirmed that the inevitable consequence of increased intervention is an increased rate of complications. A careful and thoughtful evaluation of indications, risks, and benefits of this fashionable concept is required to ensure that we are deploying valuable resources with efficacy, and that we do no harm.

Cite this article: Bone Joint J 2018;100-B:566–9.
Surgical experts and litigation
Authors: Alderson Derek
Published: April 2018

Have we had enough of experts?
The technologist: How self-driving cars could help transform healthcare.
Authors: Kerstein Ryan
Published: April 2018

How self-driving cars could help transform healthcare.
The doctor drought
Authors: Thomas J Meirion
Published: April 2018

With nearly half of new doctors having trained abroad, what does the future hold for our homegrown medical talent?
Outcomes of general paediatric surgery undertaken by urologists in regional centres
Authors: Teichmann DA , Prieto MC Hart , Jones P
Published: April 2018

How local centres can help train consultants with little experience in this area.
Treasures from the Collections
Authors: Simpson Bruce
Published: April 2018

Henry Weekes’ statue of John Hunter
Organización espacial de la pesca comercial ribereña en el Área de Protección de Flora y Fauna Laguna de Términos, México
Authors: Campos Flores Giselle Jazmín , Crespo Guerrero José Manuel
Published: April 2018

Uno de los grandes problemas ambientales que afecta el futuro socioeconómico de las comunidades que viven de los recursos del mar es el manejo pesquero inadecuado, a la par de ser una de las consecuencias del deterioro del mar, así lo puso de manifiesto la primera conferencia de Naciones Unidas sobre los Océanos (FAO, 2017). Las áreas naturales protegidas que permiten actividades extractivas como la haliéutica, a priori, disponen de herramientas de ordenación y gestión para alcanzar el desarrollo económico sin poner en riesgo sus ecosistemas. El Área de Protección de Flora y Fauna Laguna de Términos, península de Yucatán, tiene clara vocación pesquera tanto en sus aguas dulces como en las pertenecientes al Golfo de México. Allí, la pesca se ha enfrentado a importantes dificultades derivadas de la actividad de Petróleos Mexicanos (PEMEX) en la Sonda de Campeche. A pesar de disponer el espacio protegido de una herramienta de gestión, la configuración espacial de la pesca comercial ribereña presenta disfunciones. La investigación se interesa en revelar el sistema organizativo de la pesca bajo la teoría de la organización espacial de la economía. Tras la revisión bibliográfica, el trabajo de campo y la triangulación de datos cuantitativos y cualitativos, se concluye que en algunas localidades pesqueras, predominan esquemas artesanales y faltan infraestructuras para almacenar y transportar el producto. En otras, las unidades económicas se han dinamizado y orientado hacia especies de medio y alto valor comercial, han invertido en infraestructuras y encontrado canales de comercialización de mayor alcance, produciendo una mayor derrama económica.
Philosophie des HipHop
Authors: Manemann Jürgen , Brock Eike
Published: April 2018

In Gesprächen, mit Texten, Songs, Kommentaren und durch spontane Assoziationen loten Philosoph*innen und Rapper*innen (Megaloh, Sookee, Spax u.a.) miteinander aus, was Philosophie des HipHop heißt. Dabei geht es um lebendiges Philosophieren. Philosophieren im Sinne des HipHop verlangt, sich selbst aktiv einzubringen. Eigene Gedanken blitzen auf in der Konfrontation mit den Gedanken anderer. Authentizität bzw. Realness und Kreativität: das sind die Leitwerte des HipHop. Philosophie des HipHop bedeutet nicht talking philosophy, sondern doing philosophy, und zwar in der Auseinandersetzung mit den Herausforderungen der Gegenwart. Philosophie des HipHop heißt: Performen, was an der Zeit ist.
The investigation of process of teaching function concept in an Adidactic learning environment
Authors: Dikkartin Övez Filiz Tuba , Akar Nazlı
Published: April 2018

This study investigates the learning of the concept of functions in an adidactic learning environment, explains the five phases of the adidactic learning environments defined in the Didactic Situation Theory and their interactions with the milieu generated within the given problem state of the students. It was carried out with 33 ninth grade students from an Anatolian high school in Balıkesir. This qualitative study was designed as a case study. Descriptive analysis was used to analyze the data from students’ worksheets, and the transcriptions of video records in order to investigate the outcomes of an adidactic learning environment in detail. Students’ performances in the teaching process were evaluated with a checklist for problem-solving, construction of function knowledge and interaction with the milieu. The results showed that the basic conditions of an adidactic learning environment were provided, the students with a high interaction with the milieu constructed function knowledge by completing each stage. The students’ display rates for the indicators on the checklist were 70.90 % for problem-solving, 77.77% for construction of function knowledge, and 80.00% for interaction with the milieu.
Finding creative processes in learning design patterns
Authors: Philip Robyn Louise
Published: April 2018

Bridging the gap between theory and practice in higher education continues to be problematic for educators. One potential means of addressing this problem and moving practice forward is to articulate and share learning designs created from the work of exemplary practitioners. This study offers a new representation of learning design which foregrounds creative processes. The learning design patterns are in text and visual format, and they reveal where creative processes reside in the learning process. The patterns are complemented by case study narratives, so there is an opportunity to bring significant insight to pedagogical practice. The designs were derived from an in-depth, qualitative study of exemplary practitioners who teach creatively and foster student creativity within either the creative industries or social sciences. Constructivist, informed grounded theory methods were used for the case study data collection and analysis that led to the construction of the patterns. The two case study examples chosen for discussion in this paper were distilled from blended learning units where online and face-to-face learning technologies were utilised. The learning designs discussed represent an original contribution to the field and have potential to be adapted to other disciplines, beyond those from which they originated.
Some More Notes on Siderits and Katsura’s Translation of Nāgārjuna’s Mūlamadhyamakakārikā
Authors: Ferraro Giuseppe
Published: April 2018

In my recent translation (Ferraro 2016) from Sanskrit to Portuguese of Nāgārjuna’s Mūlamadhyamakakārikā I have frequently consulted, among many others, Mark Siderits and Shōryū Katsura’s English version (Siderits / Katsura 2013) of the same work. In this review article I present some places where my understanding of Nāgārjuna’s words more markedly diverges from their translation. Regarding the ideal of “an English-speaking Nāgārjuna” as a work-in-progress which could be constantly improved, my observations aim to continue the list of remarks presented by Anne MacDonald in her review article (MacDonald 2015) of Siderits and Katsura’s work.
HCV core antigen comes of age: a new opportunity for the diagnosis of hepatitis C virus infection
Authors: Galli Claudio , Julicher Paul , Plebani Mario
Published: April 2018

The diagnosis of hepatitis C virus (HCV) infection has been traditionally based on the detection of the host antibody response. Although antibody assays are available in different formats and are fairly accurate, they cannot distinguish between an ongoing infection with HCV replicative activity and a past infection where HCV has been cleared, spontaneously or after a successful therapy. As a chronic infection is mostly asymptomatic until the late clinical stages, there is a compelling need to detect active HCV infection by simple and reproducible methods. On this purpose, the clinical guidelines have suggested to search for the HCV ribonucleic acid (HCV-RNA) after anti-HCV has been detected, but this second step carries several limitations especially for population screening. The availability of fast and automated serological assays for the hepatitis C core antigen (HCVAg) has prompted an update of the guidelines that now encompass the use of HCVAg as a practical alternative to HCV-RNA, both for screening and monitoring purposes. In this paper, we summarize the features, benefits and limitations of HCVAg testing and provide an updated compendium of the evidences on its clinical utility and on the indications for use.
Azocalix[4]arene with three distal ethyl ester residues as a highly selective chromogenic sensor for Ca2+ ions
Authors: Wang Jie , Guan Hongyu , Ge Chunhua , Fan Ping , Xing Xijuan , Shang Yunshan
Published: April 2018

Three azocalix[4]arenes with distal ethyl ester residues, 5-phenylazo-25,26,27-tris[(ethoxycarbonyl)methoxy]-28-hydroxycalix[4]arene (2), 5-(o-methylphenyl)azo-25,26,27-tris[(ethoxycarbonyl)methoxy]-28-hydroxycalix[4]arene (3), 5-(p-Methylphenyl)azo-25,26,27-tris[(ethoxycarbonyl)methoxy]-28-hydroxycalix[4]arene (4), were synthesized and their binding properties with metal ions were investigated by ultraviolet (UV)/visible spectroscopy. The chromogenic behavior of these compounds upon metal ion complexation indicates a specific selectivity toward Ca2+ ion in the presence of other cations tested. The stoichiometry of 3 to Ca2+ ion in the complex is 1:1 and the stability constant of the complex is 1.28×104
m
−1.
Strategies of involvement and moral detachment inHouse of Cards
Authors: Sorlin Sandrine
Published: April 2018

The aim of this paper is to evince the reasons why the viewers tend to ‘root for the bad guy’ inHouse of Cardsin spite of his amoral undertakings. It delves into the linguistic, pragmatic and cognitive strategies employed by the protagonist, Frank Underwood, to ‘transport’ the audience in the narrative while distancing them from moral judgment. It is shown that the ‘Para-Social Relationship’ he constructs with the audience invites them to adapt to his goals and perspective, guiding their emotions and reactions, distracting them from ethical matters through generalised impersonalised aphorisms and transgressive humour. Lastly it proposes a three-level model of producing/viewing processes that are specific toHouse of Cards, highlighting the way the protagonist’s manipulation of audience involvement breaks apart in the last seasons, as the production crew alters the Frank-audience relationship.
Disjointed sum of products by a novel technique of orthogonalizing ORing
Authors: Can Yavuz
Published: April 2018

This work presents a novel combining method called ‘orthogonalizing ORing◯∨$\bigcirc\!\!\!\!\!\!\vee $’ which enables the building of the union of two conjunctions whereby the result consists of disjointed conjunctions. The advantage of this novel technique is that the results are already presented in an orthogonal form which has a significant advantage for further calculations as the Boolean Differential Calculus. By orthogonalizing ORing two calculation steps - building the disjunction and the subsequent orthogonalization of two conjunctions - are performed in one step. Postulates, axioms and rules for this linking technique are also defined which have to be considered getting correct results. Additionally, a novel equation, based on orthogonalizing ORing, is set up for orthogonalization of every Boolean function of disjunctive form. Thus, disjointed Sum of Products can be easily calculated in a mathematical way by this equation.
Generalizations of Steffensen’s inequality via the extension of Montgomery identity
Authors: Aljinović Andrea Aglić , Pečarić Josip , Pribanić Anamarija Perušić
Published: April 2018

In this paper, we obtained new generalizations of Steffensen’s inequality for n-convex functions by using extension of Montgomery identity via Taylor’s formula. Since 1-convex functions are nondecreasing functions, new inequalities generalize Stefensen’s inequality. Related Ostrowski type inequalities are also provided. Bounds for the reminders in new identities are given by using the Chebyshev and Grüss type inequalities.
Welfare und Ernährungssicherheit: Die Unterstützungsprogramme der Amministrazione per gli aiuti internazionali (Aai) von der Nachkriegszeit bis in die 60er Jahre
Authors: Inaudi Silvia
Published: April 2018

Riassunto

:L’articolo propone una panoramica critica degli interventi socio-assistenziali posti in essere dal dopoguerra alla prima meta degli anni Sessanta dall’Amministrazione per gli aiuti internazionali (Aai): organismo singolare nel panorama assistenziale italiano per le sue caratteristiche di autonomia all’interno del complesso statuale e per la fitta rete di rapporti intessuti a livello internazionale. Sotto la guida del democristiano Lodovico Montini, l’Aai si fece portatrice di istanze di modernizzazione nell’ambito di una visione che intendeva coniugare la tradizione del cattolicesimo sociale con la moderna cultura anglosassone dell’auto-aiuto, e di un modello di Welfare promanante dallo Stato ma rispettoso dell’iniziativa privata. L’attuazione dei suoi programmi, nei quali rilevante fu la focalizzazione sull’infanzia e la gioventu e l’enfasi sull’aspetto pedagogico-formativo, si accompagno al costante supporto della professionalizzazione del personale preposto ai servizi socio-assistenziali. Per il ruolo del tutto peculiare che l’Aai ebbe nel panorama dell’assistenza pubblica italiana, analizzarne la genesi e l’operato significa anche riflettere sulle contraddittorie scelte in materia di intervento sociale da parte del governo italiano nel piu ampio contesto delle intersezioni fra welfare e guerra fredda.
Le case tributarie nelle leggi e nei documenti longobardi
Authors: Carminati Fabio , Mariani Andrea
Published: April 2018

In einigen Dokumenten aus der Zeit des Langobardenreiches (7.-8. Jh.) werden spezifische Landstucke erwahnt, case tributarie genannt. Einige von diesen waren Teil der Curtis Regia (bzw. der Fiscus), wahrend andere moglicherweise in Privatbesitz waren. Alle verschwanden nach dem Niedergang des langobardischen Konigreiches. Ihre Eigenschaften wurden bislang noch nicht naher untersucht: fur gewohnlich werden die case tributarie als Aquivalent der case massaricie betrachtet, das heist als Zentren landwirtschaftlicher Produktion, welche von Siedlern bewirtschaftet wurden. Eine solche Hypothese stimmt mit den jungsten Forschungsergebnissen uberein, welche jedoch die Existenz der generellen Besteuerung im langobardischen Konigreich ausklammert, obwohl die Quellen einen anderen Zusammenhang andeuten. Durch die Analyse dieser Quellen ist es moglich hilfreiche Informationen zu erlangen, um sowohl die Funktion als auch die Hauptmerkmale der case tributarie zu interpretieren und um einige besondere Charakteristiken der langobardischen Administration aufzuzeigen. Hierfur werden wir zuerst die wenigen uberlieferten Dokumente mit Verweisen auf die case tributarie sowie einige ihrer Hauptmerkmale und Problemstellen vorstellen. In einem weiteren Schritt werden wir die bisherige historiographische Interpretation erortern. Schlieslich schlagen wir ein anderes Modell und seine Umsetzung in einer speziellen Fallstudie vor.
Zwischen München und Rom
Authors: Ferber Magnus Ulrich
Published: April 2018

Riassunto

Il carteggio del gesuita Matthaus Rader, nato nella Germania meridionale, rappresenta non solo una fonte importante per lo studio della storia culturale bavarese, ma offre anche un’importante testimonianza per il transfer culturale tra l’Italia e la Germania all’inizio del XVII secolo. I suoi progetti editoriali sia filologici che storici spesso necessitavano, nel contesto delle procedure di censura interne all’ordine, dell’approvazione da parte della curia generalizia. Da cio derivava un regolare scambio epistolare con la Citta eterna che apriva a Rader l’accesso a manoscritti rari, conservati a Roma, e lo metteva in contatto con i bibliotecari locali. Tali rapporti facevano di lui un importante interlocutore per viaggiatori diretti da Roma verso la Baviera, ad esempio Leone Allacci, il quale nel 1623 avrebbe dovuto trasferire i fondi della Palatina in Italia. La posizione di Rader come storiografo ufficiale della corte bavarese comportava che egli propagasse a Roma la visione storica del suo committente, il duca Massimiliano I. Il contrasto provocato da Abraham Bzowski con Massimiliano per la rappresentazione dell’imperatore Ludovico IV nei suoi Annales ecclesiastici porto Rader sull’orlo di un conflitto con il preposito generale dei gesuiti, Vitelleschi; in tale cornice si concepi piuttosto come attore sullo sfondo della politica culturale bavarese.
Radioiodinated celiprolol as a new highly selective radiotracer for β1-adrenoceptor-myocardial perfusion imaging
Authors: Sanad M. H. , Talaat H. M. , Ibrahim I. T. , Saleh G. M. , Abouzeid L. A.
Published: April 2018

The present study was oriented to synthesis radioiodinated celiprolol (Cel) for a potential cardiac imaging. Celiprolol has been labeled using 125I with chloramine-T (Ch-T) as an oxidizing agent. The key effective factors such as amount of oxidizing agent, amount of substrate, pH, reaction temperature and reaction time, have been systematically studied to optimize the iodination. The biological distribution indicates the suitability of radioiodinated Cel as a novel tracer to image heart.
The Photoelectrochemistry of Assemblies of Semiconductor Nanoparticles at Interfaces
Authors: Hickey Stephen G.
Published: April 2018

The application of photoelectrochemical methods presents the researcher with a powerful set of versatile tools by which photoactive materials, such as semiconductor quantum dots, at conductive interfaces may be interrogated. While the range of photoelectrochemical techniques available is quite large, it is surprising that very few have found their way into common usage within the nanoparticle community. Here a number of photoelectrochemical techniques and the principles upon which they are based are introduced. A short discussion on the criticality of ensuring the nanoparticles are reliably anchored to the substrate is followed by an introduction to the basic set of equipment required in order to enable the investigator to undertake such experiments. Subsequently the four techniques of transient photocurrent response to square wave illumination, photocurrent spectroscopy, intensity modulated photocurrent spectroscopy and intensity modulated photovoltage spectroscopy are introduced. Finally, the information that can be acquired using such techniques is provided with emphasis being placed on a number of case studies exemplifying the application of photoelectrochemical techniques to nanoparticles at interfaces, in particular optically transparent electrodes.
New Tool to Control and Monitor Weighted Vest Training Load for Sprinting and Jumping in Soccer
Authors: Carlos-Vivas Jorge , Freitas Tomás T. , Cuesta Miguel , Perez-Gomez Jorge , De Hoyo Moisés , Alcaraz Pedro E.
Published: April 2018

Carlos-Vivas, J, Freitas, TT, Cuesta, M, Perez-Gomez, J, De Hoyo, M, and Alcaraz, PE. New tool to control and monitor weighted vest training load for sprinting and jumping in soccer. J Strength Cond Res 33(11): 3030–3038, 2019—The purpose of this study was to develop 2 regression equations that accurately describe the relationship between weighted vest loads and performance indicators in sprinting (i.e., maximum velocity, Vmax) and jumping (i.e., maximum height, Hmax). Also, this study aimed to investigate the effects of increasing the load on spatio-temporal variables and power development in soccer players and to determine the “optimal load” for sprinting and jumping. Twenty-five semiprofessional soccer players performed the sprint test, whereas a total of 46 completed the vertical jump test. Two different regression equations were developed for calculating the load for each exercise. The following equations were obtained: % body mass (BM) = −2.0762·%Vmax + 207.99 for the sprint and % BM = −0.7156·%Hmax + 71.588 for the vertical jump. For both sprinting and jumping, when the load increased, Vmax and Hmax decreased. The “optimal load” for resisted training using weighted vest was unclear for sprinting and close to BM for vertical jump. This study presents a new tool to individualize the training load for resisted sprinting and jumping using weighted vest in soccer players and to develop the whole force-velocity spectrum according to the objectives of the different periods of the season.
Drift in Neural Population Activity Causes Working Memory to Deteriorate Over Time
Authors: Schneegans Sebastian , Bays Paul M.
Published: April 2018

Short-term memories are thought to be maintained in the form of sustained spiking activity in neural populations. Decreases in recall precision observed with increasing number of memorized items can be accounted for by a limit on total spiking activity, resulting in fewer spikes contributing to the representation of each individual item. Longer retention intervals likewise reduce recall precision, but it is unknown what changes in population activity produce this effect. One possibility is that spiking activity becomes attenuated over time, such that the same mechanism accounts for both effects of set size and retention duration. Alternatively, reduced performance may be caused by drift in the encoded value over time, without a decrease in overall spiking activity. Human participants of either sex performed a variable-delay cued recall task with a saccadic response, providing a precise measure of recall latency. Based on a spike integration model of decision making, if the effects of set size and retention duration are both caused by decreased spiking activity, we would predict a fixed relationship between recall precision and response latency across conditions. In contrast, the drift hypothesis predicts no systematic changes in latency with increasing delays. Our results show both an increase in latency with set size, and a decrease in response precision with longer delays within each set size, but no systematic increase in latency for increasing delay durations. These results were quantitatively reproduced by a model based on a limited neural resource in which working memories drift rather than decay with time.

SIGNIFICANCE STATEMENTRapid deterioration over seconds is a defining feature of short-term memory, but what mechanism drives this degradation of internal representations? Here, we extend a successful population coding model of working memory by introducing possible mechanisms of delay effects. We show that a decay in neural signal over time predicts that the time required for memory retrieval will increase with delay, whereas a random drift in the stored value predicts no effect of delay on retrieval time. Testing these predictions in a multi-item memory task with an eye movement response, we identified drift as a key mechanism of memory decline. These results provide evidence for a dynamic spiking basis for working memory, in contrast to recent proposals of activity-silent storage.
Rapid-onset diabetic ketoacidosis secondary to nivolumab therapy
Authors: Lee Senhong , Morgan Aparna , Shah Sonali , Ebeling Peter R
Published: April 2018

We report a case of a 67-year-old man with type 2 diabetes presented with diabetic ketoacidosis, two weeks after his first dose of nivolumab therapy for non–small-cell lung carcinoma. He was started on empagliflozin two days prior in the setting of hyperglycaemia after the initiation of nivolumab therapy. Laboratory evaluation revealed an undetectable C-peptide and a positive anti-glutamic acid decarboxylase (GAD) antibody. He was treated with intravenous fluids and insulin infusion and was subsequently transitioned to subcutaneous insulin and discharged home. He subsequently has developed likely autoimmune thyroiditis and autoimmune encephalitis.

Learning points:

Glycemic surveillance in patients receiving immune checkpoint inhibitors is recommended.

Early glycemic surveillance after commencement of anti-programmed cell death-1 (PD-1) inhibitors may be indicated in selected populations, including patients with underlying type 2 diabetes mellitus and positive anti-glutamic acid decarboxylase (GAD) antibody.

Sodium-glucose co transporter-2 (SGLT2) inhibitors should be used with caution in patients on immunotherapy.
TIRADS score is of limited clinical value for risk stratification of indeterminate cytological results
Authors: Chaigneau E , Russ G , Royer B , Bigorgne C , Bienvenu-Perrard M , Rouxel A , Leenhardt L , Belin L , Buffet C
Published: April 2018

Context

Thyroid nodules with cytological indeterminate results represent a daily and recurrent issue for patient management.

Objective

The primary aim of our study was to determine if TIRADS (Thyroid Imaging Reporting and Data System) could be used to stratify the malignancy risk of these nodules and to help in their clinical management. Secondary objective was to estimate if this risk stratification would change after reclassification of encapsulated non-invasive follicular variant of papillary carcinomas (FVPTC) as non-invasive follicular thyroid neoplasm (NIFTP).

Patients and methods

Single-center retrospective study of a cohort of 602 patients who were referred for ultrasound-guided fine-needle aspiration from January 2010 to December 2016 with an indeterminate cytological result and in whom histological results after surgery were available. TIRADS score was prospectively determined for all patients included. Nodules that had been classified as FVPTC were submitted to a rereading of histological report and reclassified as NIFTP when judged relevant. A table of malignancy risk crossing Bethesda and TIRADS results was built before and after this reclassification.

Results

The study included 602 cytologically indeterminate nodules. TIRADS score was positively correlated with the malignancy rate (P < 0.0001). Risk stratification with TIRADS was significant only in Bethesda V nodules (P = 0.0004). However, the risk of malignancy in this Bethesda V category was always above 45%, whatever the TIRADS score.

Conclusion

For a clinician facing an indeterminate cytological result for a thyroid nodule, return to TIRADS score is of limited value in most conditions to rule in or rule out malignancy and to guide subsequent management of patients.
The kinetics of adsorption binding of Ba2+ ions by trimethylsilylated silica
Authors: Myronyuk I. F. , Vasylyeva H. V. , Mandzyuk V. I. , Bezruka N. A. , Dmytrotsa T. V.
Published: April 2018

It was established that incomplete substitution of free silanols of fumed silica surface on (CH3)3Si-groups leads to an increase in the ability of modified SiO2 to adsorb Ba2+ cations from an electrolyte solution. Silica with 48.3% of trimethylsilyl (TMS) groups adsorbs 1.8 mmol·g-1 of Ba2+ cations from 0.01 M BaCl2 solution, that in 3 times more than the adsorption of these cations by unmodified silica. It was found that the adsorption of cations by basic and modified silica is well described by the pseudo-second order Lagergren equation. The high adsorption activity of silica with chemisorbed TMS-groups is due to the formation of local regions with relatively large values of negative and positive electrostatic potentials in the vicinity of grafted TMS-groups.
Dynamics of morphological and biochemical indicators of blood of sucking piglets at different levels of iodine citrate in sows rations
Authors: Hunchak R. V. , Sedilo H. M.
Published: April 2018

The article presents the results of experimental studies on the determination of the influence of iodine citrate on hematological and biochemical parameters of blood of sucking piglets. It was established that hemopoiesis and metabolic reactions in pigs depend on the level of Iodine in the sows, and in the later period (the 10th day) and from the receipt of the biometal as part of the prestarter. Iodine, in nanocitate form, at the expense of high bioavailability and chemical activity, provided the need for thyroid gland in it in much less quantities than the amounts recommended for pregnant and lactating sows in the form of potassium iodide. It has been established that at the admission to the body of a sow 0.095–0.19 mg/kg of feeding of iodine in a nanocyte form (1/4–1/2 of the recommended amount of iodine in the form of CI), its positive effect on hemopoiesis and metabolic processes in newborn piglets is peculiar (increased number of red blood cells, hemoglobin content, high percentage of lymphocytes, increases in the concentration of total protein and in particular albumin, against the backdrop of growth in blood plasma levels of CSF, the concentration of hormones T3 and T4 is quite stable. A higher dose in the premix of iodine citrate (1 : 1) is irrational and most likely undesirable, since against the background of inhibition of this group of erythropoiesis, eosinophilia and lymphopenia, the protein synthesis function decreases and the activity of AlAT, AsAT increases. Hematological and biochemical parameters of blood of piglets obtained from sows, which received a minimum amount of iodine in the form of citrate (0.1 : 1) with premix, did not undergo significant changes, were within the limits of physiological values, although in comparison with the animals of the control group, and particularly, the piglets of the group D2 and D3 tended to decrease (growth). Consequently, iodine citrate as a source of iodine for pregnant and subsistence sows can be recommended in the amounts: 0.095–0.19 mg/kg and 0.125–0.25 mg/kg feed.
Effect of aquacitrate of micro elements on indices of nonspecific resistance and cellular immunity in chicken broilers
Authors: Medvid S. M.
Published: April 2018

The article presents data on the influence of the complex of micro elements (Fe, Cu, Zn, Co, Mn) in the form of aquacitrate on the indices of non-specific and cellular immunity in chicken broilers. The poultry received a fodder, balanced by nutrients, according to its type, age and productivity. Control group of chickens were added standard mineral premix (SP) from inorganic compounds of bioelements. Broilers of experimental groups were given water with a complex mineral additive of aquacitrates. In particular, the chickens of the first experimental group – in the amount corresponding to their content in the standard premix (SP), and the 2nd, 3rd, 4th and 5th experimental groups – in the amount equal to 3/4, 1/2, 1/4 and 1/10 of the content of mineral elements in the standard premix. It was found that bactericidal and lysozyme activity of blood serum (BASB and LASB) were the highest in broiler chickens of the third and fourth experimental groups and exceeded the control values by 5.7 and 5.3%, respectively. In the bird of the second and fifth groups, the studied indicators were closer to the ones in control. However, in the chickens of the group D1, giving them the highest studied dose of aquacitrate of micor elements, the values of BASB and LASB tended to decrease. Concerning the level of CIC in serum, it was the highest in the chickens of the second, third and fourth groups, the lowest in the group D1. A similar pattern is also characteristic for phagocytic activity of pseudoiesinophils (PhA). The bite of half and even the quaternary amount of citrates of micro elements, compared with the amount of bioelements in inorganic form, provided an increase, compared to control, of PhA. At such a dose of micro elements in the nanoform in the blood of broilers, the number of T-total and T-active lymphocytes increased, including T-heeler cells and decreased the relative number of T-suppressors. The bird of the first experimental group was characterized by a decrease in the percentage of T-heeler against the background of a slight increase of T-suppressors. Thus, the results of studies of indices of nonspecific and cellular immunity suggest that micor elements in the nanodisperse form, due to better bioavailability and high bioactivity, have a positive effect on the formation and development of the immune system in broiler chickens at a dose corresponding to 25 and 50%, from recommended quantity of biometals in the standard premix.
Productive qualities of ducklings with different normalization methods trace elements in the diet
Authors: Ibatullin I. I. , Holubiev M. I. , Otchenashko V. V. , Makhno K. I.
Published: April 2018

In the article, results of researches on an establishment of an optimum source of Manganese, Zinc, Iron and Copper are resulted. Different source Manganese, Zinc, Iron and Copper was additionally added mixed fodder for ducklings grown for meat. Experimental studies conducted in terms of problem research laboratory of feed additives National University of Life and Environmental Sciences of Ukraine. Independent experiment was conducted with growing meat ducklings. We conducted a randomized block experiment with 5 treatments, each with 4 replicates of 25 growing ducks (1 to 42 d of age). A diet consisting of corn, soybean and sunflower meal, fish meal, premix (22.5% CP, 2.92 kcal of ME/g on 1 to 14 d of age, 18.5% CP, 2.90 kcal of ME/g on 15 to 42 d of age) having severally Manganese, Zinc, Iron, Copper at sulphate, glycinate and citrate. The premix was formulated to contain the requirements of trace elements in combination of either inorganic (sulphate form) or organic form (glycinate and citrate form). Diets were supplemented with the organic form of zinc, copper, manganese or iron at the rate of 100% or 75% of the total requirements of the elements. Diets and water were offered ad libitum. After 6 weeks of dietary treatments the growth performance (feed intake, body weight, daily gain, feed conversion, homogeneity of the poultry) were affected by dietary treatments. Results indicated that chicks fed diets containing 100% organic minerals (Mn, Zn, Fe, Cu) had significantly higher body weight, better feed conversion compared with those of inorganic control minerals treatment. Use of fodder for ducklings, which are grown for meat glycinate Mn, Zn, Fe, Cu versus sulfate improves their productive performance. The body weight of ducklings at 42 d of age is more by 1.6% (P < 0.05) and the conversion of feed is 1.0% higher. The conversion of feed from consumption was rather high (R2=0.84), which confirms the change in the productive indicators of duckling from the feed factor.
Productivity of growing rabbits at different levels of methionine in the diet
Authors: Sychov M. Yu. , Holubieva Т. А. , Pozniakovskyi Yu. V. , Andriienko L. M. , Holubiev M. I.
Published: April 2018

The article presents the results of experimental studies on the influence of various levels of methionine in feed on the productivity of growing rabbits. The research was conducted in the conditions of the problematic research laboratory of feed additives of the National University of Life and Environmental Sciences of Ukraine. Experiment was carried out on young rabbits HYLA hybrids of the French company EUROLAP, of which, on the principle of analogues, four groups were formed – control and 3 experimental, with 20 heads (10 females and 10 males) in each. The experiment lasted 42 days. Every week we conducted individual weighings of the experimental animals, calculation of weight gains and feed costs. For feeding of the experimental rabbits were used diets, which were balanced by energy and main nutritional elements, but differed in the content of methionine – the rabbits of the control group consumed feed containing methionine 0.29%, the second – 0.41%, the third – 0.54%, the fourth – 0.66%. Diet consisted of wheat bran, sunflower meal, sunflower hulls, alfalfa grass meal, premix and bone concentrate. At the 84th day of age, the largest body weight was in rabbits, which consumed feed containing methionine 0.41% – 3005.4 g, which is on 3.2% (P < 0.01) more than in the control. Over the entire period of the experiment largest absolute increase was observed in rabbits of second group (0.41% of methionine) and preponderated the indicator of animals of control group at 5.7% (P < 0.001). The average daily gain for the entire period of the experiment was the highest in rabbits of the second group, which was on 5.8% (P < 0.001) more than in control. Calculations of feed costs for the period of growth 42–84 days indicate that the rabbits that consumed a feed containing 0.66% methionine per 1 kg of body weight gain consumed it by 2.3% less than control, and those who consumed feed with contents 0.54% methionine – by 1.5% less, 0.41% methionine – by 1.2% less. According to experimental results, we can conclude that for maximum increases in body weight with moderate cost of feed per unit of weight must use diet containing methionine 0.41%.
Microsatellite diversity in the populations of Ukrainian local chicken breeds
Authors: Kulibaba R. O. , Liashenko Y. V.
Published: April 2018

The article considers the questions about microsatellite diversity in the populations of Birkivska Barvista (line A), White Plymouth Rock (line G-2), Poltava clay (line 14) and Rhode Island Red (line 38) chicken breeds. Using the classical PCR method, populations polymorphism was studied for 14 microsatellite loci (LEI0094, LEI0166, LEI0192, ADL0268, ADL0278, MCW0034, MCW0081, MCW0104, MCW0123, MCW0330, MCW0245, MCW0257, MCW0282, MCW0288). For all microsatellite loci 66 alleles were detected. For the population of White Plymouth Rock chicken breed, the number of individual alleles in all the loci was 64; for Birkivska Barvista – 50; for Rhode Island Red – 50; for Poltava clay – 52. By the values of the polymorphism information content (PIC), the number of highly informative markers was ~ 45% of the total. According to the results of the research, it was revealed that the biggest genetic differences were between the White Plymouth Rock and Rhode Island Red chicken breeds (65.9% of differences), the smallest were between White Plymouth Rock and Poltava clay chicken breeds (32.3%). Between lines 14 and 38 (the egg-meat direction of productivity), 35.9% of the differences were observed. By comparison of the population of Borkovskaya Barvistaya chicken breed (line A), the maximum differences were found with the Rhode Island Red (58.8%), while the G-2 and 14 lines showed similar differences (32.8 and 37.9%). According to Wright's F-statistics analysis, 19.5% of detected genetic variability was between populations that indicating a significant divergence of the experimental chicken lines. Among all studied loci, the average level of divergence (the value of Fst was within the range of 0.06–0.15) is characteristic for 29% of the total number of microsatellite markers; strongly expressed divergence (0.16–0.25) for 57% and very strong (> 0.25) for 14% (locus MCW0257 and MCW0288). By averaged values of Fis, negative values (excess of heterozygotes) were shown only for 3 from all studied loci. The average Fit value indicates a significant (27.5%) excess of homozygous individuals what indicates the high level of inbreeding in experimental chicken populations and reaches its maximum value in the MCW0245 and MCW0257 loci.
Resource-saving milk production technologies with use of easy-assembled premises and high-performance milking plants
Authors: Lutsenko M. M. , Galay O. Yu.
Published: April 2018

High productivity of dairy cows in the conditions of new innovative technologies can not be obtained without providing comfortable conditions for their functioning.In this connection, the conditions for maintaining high-yielding cows in various types of livestock buildings are investigated: the traditional, 24.0 m wide and new unassembled, 32.5 m wide and 36.0 m in extreme periods of the year. The different width of the premises is due to the need to use different types of milking plants: MilkProud, Parallel, Carousel and robotic milking systems.Studies have established that volumetric-planning and technological solutions for easy-assembled premises increase the volume of space per head from 45.6 m3 to 96.3 m3 and 129.6 m3. It positively affects the conditions for the maintenance of highly productive cows. The presence in their design of side curtains and light-aeration ridge increases the speed of air in 3 times. This provides a reduction in the concentration of ammonia in 8 times, and bacterial pollution at 18.7 times compared with traditional barn.Increasing the volume of the room up to 129.6m³ per head reduces the bacterial air pollution in the winter period to a minimum value of 2.8 thousand/m³. New elements in the design of easy-assembled spaces provide resource-saving and organizing their lighting.According to the existing standards in Ukraine, the lighting in the feeding area should be at 52 lux. In traditional rooms, this level is achieved only by installing additional energy sources, which provide an increase in lighting from 31 lux to 52 lux. In new types of premises the required level of lighting is provided naturally, which leads to significant energy savings. It was established that technological solutions of easy-assembled premises provide comfortable conditions for recreation of high-yielding cows.In these types of rooms, the animals rest 12.4% and 20.0% more time compared to traditional rooms. Feeding of cows in easy-assembled premises from the stern table provides quick feeding of animals with feed. At the same time the time consumed for feed consumption in new types of barns is significantly less and is 252.0–246.0 min a day compared to 320.2 min in traditional premises where feeding is carried out from traditional feeding troughs.It is positive that in the new types of premises in animals there is a new important element of behavior – the movement, which they spend 8.6% and 9.9% of the time. New types of premises with resource-saving milk production technologies have a positive effect on the conditions for the maintenance of highly productive cows and can be widely implemented in Ukraine.
On uniqueness of a classical solution of the system of non-linear 1-D Saint Venant equations
Authors: Lai Hoang Van , Long Le Mau , Chung Mai Dinh
Published: April 2018

In this paper the theorem of uniqueness of a classical solution of the system of non-linear 1-D Saint Venant equations is proved. This uniqueness theorem is setup for the system of non-linear 1-D Saint Venant equations in canonical form under respective initial and boundary conditions.
On the element free Galerkin method in the static-analysis for the 2-D elastic-linear problem
Authors: Son Nguyen Hoai , Quang Nguyen The
Published: April 2018

The Element Free Galerkin (EFG) method is a mesh less method for solving partial differential equations in which the trial and test functions employed in the discretization process result from moving least square interpolations (weak form of the variation AL principle). In this paper, the EFG method for solving problems in least-statics {1-D, 2-D) is developed and numerically implemented. The present method is a mesh less method, as it does not need a "finite element mesh" and it is only composed by the particles with theirs "compact support" (the influence domain) in the whole domain. Specially, the shape functions are not satisfying the Kronecker delta property, therefore, in this paper, we must enforce the essential boundary conditions by the Lagrangian multipliers method. Finally, several numerical examples are presented to illustrate the performance of the EFG method. The results are compared with the other method (EFM) and also with the analytic solutions. It shows that the EFG method gives the good effectiveness of the proposed error estimator in the global energy norm and the high rates of convergence with the size of the "compact support".
Analysis of dynamics of automobile cranes with the account of the rope elasticity
Authors: Di Phan Nguyen , Gay Bui Khac
Published: April 2018

Up to now, there is still a little of attention paid on the dynamical analysis of automobile crane system and only simple dynamical models are used for the related studies. In this paper, a relatively comprehensive model describing the dynamics of automobile crane with only the body lifting mechanism taken into account is presented. The numerical solution has been derived, illustrated by graphics and assessed.
Numerical simulation of fluid mud layer in estuaries and coastal areas
Authors: Chung Dang Huu
Published: April 2018

In this paper the formation and development of fluid mud layer happening in estuaries and coastal areas are studied in detail through numerical simulation on the basis of the 2D shallow water equations for tidal flow, the advection-diffusion equation for cohesive sediment transport and the equations for fluid mud transport. Numerical solution of a special case for a part of the Severn estuary is obtained using the finite difference method as an illustration of the applicability of the model in practice. On the basis of the results, initial remarks and evaluation are given.
Stability of viscoelastic plates in shear
Authors: Doanh Pham Quoc , Tan To Van
Published: April 2018

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An equivalent linearization for the drag force in the Morison's equation using Hermite polynomial error sample function
Authors: Thinh N. H. , Anh N. D. , Cuong D. A.
Published: April 2018

Within the scope Gaussian equivalent linearization (GEL), a new mean square criterion based on Hermite polynomial error sample functions for determining the coefficients of the equivalent linearization is proposed to linearize non-linear functions of the zero mean Gaussian random process. Application to the Morison's equation for wave forces is presented that shows significant improvements over the corresponding accuracy of the classical GEL.