bluuebunny/crossref_metadata_2025 huggingface dataset:
In silico and in vitro potentials of crocin and amphotericin B on Leishmania major: Multiple synergistic mechanisms of actions
Authors: Salarkia Ehsan , Sharifi Iraj , Keyhani Alireza , Tavakoli Oliaee Razieh , Khosravi Ahmad , Sharifi Fatemeh , Bamorovat Mehdi , Babaei Zahra
Published: September 2023

A significant barrier to optimal antileishmanial treatment is low efficacy and the emergence of drug resistance. Multiple approaches were used to monitor and assess crocin (a central component of saffron) mixed with amphotericin B (AmpB) potential in silico and in vitro consequences. The binding behavior of crocin and iNOS was the purpose of molecular docking. The results showed that crocin coupled with AmpB demonstrated a safe combination, extremely antileishmanial, suppressed Leishmania arginase absorption, and increased parasite death. This natural flower component is a robust antioxidant, significantly promoting the expression of the Th1-connected cytokines (IL12p40, IFN-γ, and TNF- α), iNOS, and transcription factors (Elk-1, c-Fos, and STAT-1). In comparison, the expression of the Th2-associated phenotypes (IL-10, IL-4, and TGF-β) was significantly reduced. The leishmanicidal effect of this combination was also mediated through programmed cell death (PCD), as confirmed by the manifestation of phosphatidylserine and cell cycle detention at the sub-GO/G1 phase. In conclusion, crocin with AmpB synergistically exerted in vitro antileishmanial action, generated nitric oxide and reactive oxygen species, modulated Th1, and Th2 phenotypes and transfer factors, enhanced PCD profile and arrested the cell cycle of Leishmania major promastigotes. The main action of crocin and AmpB involved wide-ranging mechanistic insights for conducting other clinical settings as promising drug candidates for cutaneous leishmaniasis. Therefore, this combination could be esteemed as a basis for a potential bioactive component and a logical source for leishmanicidal drug development against CL in future advanced clinical settings.
Habitual behavior of household food expenditure by store type in the United States
Authors: Lee Keehyun , Capps Oral
Published: September 2023

We examine how socio-demographic factors, spending habits, and characteristics of the retail food environment affect household expenditure across all food and beverage categories by store outlet in the United States. The six outlets considered are grocery stores, convenience stores, discount stores, club stores, drug stores, and dollar stores. The source of data for this analysis is the Nielsen Homescan Panel over the period between 2011 and 2015. We employ a dynamic correlated random effect Tobit model to incorporate habitual purchasing behavior as well as a novel method to deal with zero observations using the inverse hyperbolic sine transformation. The results suggest that habitual spending behavior undoubtedly is a key factor in affecting food and beverage expenditures across all store outlets. Additionally, household size, age, urbanization, education, race, ethnicity, and region are drivers of household food and beverage expenditures across the six store outlets.
The role of infectious disease consultations in the management of patients with fever in a long-term care facility
Authors: Moon Soo-youn , Lim Kyoung Ree , Son Jun Seong
Published: September 2023

Background

Infectious disease (ID) clinicians can provide essential services for febrile patients in tertiary hospitals. The aim of this study was to evaluate the role of ID consultations (IDC) in managing hospitalized patients with infections in an oriental medical hospital (OMH), which serves as a long-term care facility. To our knowledge, this is the first study on the role of IDCs in managing patients in an OMH.

Methods

This retrospective study was conducted in an OMH in Seoul, Korea, from June 2006 to June 2013.

Results

Among the 465 cases of hospital-acquired fever, 141 (30.3%) were referred for ID. The most common cause of fever was infection in both groups. The peak body temperature of the patient was higher in IDC group (38.8±0.6°C vs. 38.6±0.5°C, p<0.001). Crude mortality at 30 days (14.6% vs. 7.8%, p = 0.043) and infection-attributable mortality (15.3% vs. 6.7%, p = 0.039) were higher in the No-IDC group. Multivariable analysis showed that infection as the focus of fever (adjusted Odd ratio [aOR] 3.49, 95% confidence interval (CI) 1.64–7.44), underlying cancer (aOR 10.32, 95% CI 4.34–24.51,), and multiorgan dysfunction syndrome (aOR 15.68, 95% CI 2.06–119.08) were associated with increased 30-day mortality. Multivariate analysis showed that in patients with infectious fever, appropriate antibiotic therapy (aOR 0.19, 95% CI 0.05–0.76) was the only factor associated with decreased infection-attributable mortality while underlying cancer (aOR 7.80, 95% CI 2.555–23.807) and severe sepsis or septic shock at the onset of fever (aOR 10.15, 95% CI 1.00–102.85) were associated with increased infection-attributable mortality.

Conclusion

Infection was the most common cause of fever in patients hospitalized for OMH. Infection as the focus of fever, underlying cancer, and MODS was associated with increased 30-day mortality in patients with nosocomial fever. Appropriate antibiotic therapy was associated with decreased infection-attributable mortality in patients with infectious fever.
A class of singularly perturbed Robin boundary value problems in critical case
Authors: Zhang Hao , Wang Na
Published: September 2023

This paper discusses a class of nonlinear singular perturbation problems with Robin boundary values in critical cases. By using the boundary layer function method and successive approximation theory, the corresponding asymptotic expansions of small parameters are constructed, and the existence of uniformly efficient smooth solutions is proved. Meanwhile, we give a concrete example to prove the validity of our results.
Infinite memory effects on the stabilization of a biharmonic Schrödinger equation
Authors: de A. Capistrano-Filho Roberto , de Jesus Isadora , Gonzalez Martinez Victor Hugo
Published: September 2023

This paper deals with the stabilization of the linear biharmonic Schrödinger equation in an $n$-dimensional open bounded domain under Dirichlet–Neumann boundary conditions considering three infinite memory terms as damping mechanisms. We show that depending on the smoothness of initial data and the arbitrary growth at infinity of the kernel function, this class of solution goes to zero with a polynomial decay rate like

t

−
n

depending on assumptions about the kernel function associated with the infinite memory terms.
Qualitative analysis on the diffusive Holling–Tanner predator–prey model
Authors: Zhao Xu , Zhou Wenshu
Published: September 2023

We consider the diffusive Holling–Tanner predator–prey model subject to the homogeneous Neumann boundary condition. We first apply Lyapunov function method to prove some global stability results of the unique positive constant steady-state. And then, we derive a non-existence result of positive non-constant steady-states by a novel approach that can also be applied to the classical Sel'kov model to obtain the non-existence of positive non-constant steady-states if
0
<
p
≤
1
.
Public opinion evaluation on social media platforms: a case study of High Speed 2 (HS2) rail infrastructure project
Authors: Yao Ruiqiu , Gillen Andrew
Published: September 2023

Public opinion evaluation is becoming increasingly significant in infrastructure project assessment. The inefficiencies of conventional evaluation approaches can be improved with social media analysis. Posts about infrastructure projects on social media provide a large amount of data for assessing public opinion. This study proposed a hybrid model which combines pre-trained RoBERTa and gated recurrent units for sentiment analysis. We selected the United Kingdom railway project, High Speed 2 (HS2), as the case study. The sentiment analysis showed the proposed hybrid model has good performance in classifying social media sentiment. Furthermore, the study applies latent Dirichlet allocation topic modelling to identify key themes within the tweet corpus, providing deeper insights into the prominent topics surrounding the HS2 project. The findings from this case study serve as the basis for a comprehensive public opinion evaluation framework driven by social media data. This framework offers policymakers a valuable tool to effectively assess and analyse public sentiment.
Estudo de lexicografia da macroestrutura e microestrutura dos dicionários de línguas de sinais de diferentes seis países como base
Authors: Boldo Jaqueline , Stumpf Marianne Rossi
Published: September 2023

O presente artigo tem como tema o estudo de dicionários de línguas de sinais de diferentes países como base de investigação. Apresentamos como fundamentos teóricos os conceitos das ciências da Lexicografia, Metalexicografia, discorrendo sobre macroestrutura e microestrutura com destaque para os estudos de dicionários e a sistematização desses estudos, e conceitos que se referem aos aspectos educacionais e linguísticos. Apresentamos uma descrição dos elementos composicionais da estrutura textual dos seguintes dicionários de línguas de sinais publicados em diferentes países: Gebärden-Lexikon Grundgebarden (Maisch; Wiscr, 1990); Dicionário Bilíngue Elementare della Lingua Italiana dei Segni (Radutzky, 1992); American Sign Language Dictionary (Sternberg, 1998); Diccionario de la Lengua de Signos Española (Pinedo Peydró, 2005); Dicionário Prático de Língua Gestual Guineense (Martins; Morgado, 2017) e Dicionário da Língua de Sinais do Brasil (Capovilla; Raphael, 2001). Ademais, abordamos os aspectos educacionais e linguísticos nos campos da Lexicografia e da Metalexicografia, priorizando autores como Barbosa (1995); Welker (2004); Costa e Nascimento (2015); Henriques (2018); Durão (2018); Durão, Boldo, Lohn e Vieira (2018); Martin, Stumpf e Martin (2018); Tuxi e Felten (2018). As pesquisas realizadas no âmbito dos estudos que analisam materiais lexicográficos, sua macroestrutura e sua microestrutura, podemos destacar o enfoque nos dicionários e seus aspectos relevantes, a produtividade nas línguas em relação às questões culturais, de uso do léxico e de expressões marcadas culturalmente. Ao analisar os dados de unidades da organização em dicionários de língua de sinais em diferentes países, acreditamos que, além de registrar as produções nas línguas selecionadas, também colaboram para que consulentes surdos e ouvintes possam compreender melhor as possibilidades das línguas em uso.
IBN THUFAIL'S PHILOSOPHICAL THOUGHTS IN THE STORY OF HAYY BIN YAQDZON
Authors: Iqbal Moch , Mukaromah Melisa
Published: September 2023

Abstract

 

The purpose of this study is to examine and explain and convey his philosophical thoughts in various aspects through the story of Hayy bin Yaqdzon. Therefore researchers are interested in conducting in-depth research on how the philosophical thoughts of Ibn Thufail are contained in the story of Hayy bin Yaqdzon. This research uses the Library Research method (literature study) with qualitative descriptive. As a result of this research, the researcher concludes that the philosophical thoughts of Ibn Thufail contained in the story of Hayy bin Yaqdzon include ontological aspects regarding nature and being (Hayy bin Yaqdzon's origins, matter and form as well as arguments proving the existence of God), epistemological aspects regarding sources of knowledge (mind). , five senses and revelation) as well as axiological aspects including ethics (towards God, environment and social).

 

Keywords: Philosophical Thought, Ibn Thufail, Acts, Hayy bin Yaqdzon.
Producción científica en Colombia relacionada con ciencia abierta, métricas de nueva generación y métricas responsables en el contexto de Publindex y SCIENTI. Algunas características y perspectivas para apoyar una Política NacionalProducción científica en Colombia relacionada con ciencia abierta, métricas de nueva generación y métricas responsables en el contexto de Publindex y SCIENTI
Authors: Uribe-Tirado Alejandro , Vélez-Cuartas Gabriel-Jaime , Pallares-Delgado Cesar-Orlando
Published: September 2023

Este artículo presenta una revisión del tema sobre la publicación de autores colombianos durante los últimos años (2000-2020) en relación con la ciencia abierta, las métricas de nueva generación (altmetrics) y las métricas responsables, en interrelación contextual con las prácticas de evaluación y medición de revistas científicas (Publindex) y de grupos de investigación e investigadores (SCIENTI) en el país, considerando los cambios que implica la reciente aprobación de la Política Nacional de Ciencia Abierta. El listado de textos, seleccionados mediante un análisis cualitativo, es un insumo importante en las discusiones y nuevas construcciones en torno a dicha Política Nacional, para que la valoración, el reconocimiento y la evaluación de las actividades de ciencia, tecnología e innovación del país incluyan métricas responsables e indicadores alternativos de ciencia abierta centrados en valorar la diversidad de los productos y los procesos adelantados, así como los diferentes impactos económicos, sociales y territoriales generados por estas prácticas.
Studi Kasus: Pertolongan Pertama Kegawatdaruratan pada Suspek Hipernatremia di Rumah
Authors: Poespodiwirjo Nur Hafizhah
Published: September 2023

Hipernatremia dapat menyebabkan kematian akibat gangguan cairan tubuh sehingga menimbulkan rusaknya sel-sel otak. Penelitian terkait penggunaan kalium dalam manajemen hipernatremia dan tatalaksana kasus hipernatremia pasien hipersensitif obat masih terbatas. Penelitian ini bertujuan untuk mendeskripsikan tindakan pertolongan pertama pada suspek hipernatremia yang hipersensitif obat. Studi kualitatif ini adalah studi kasus di bidang kesehatan (case report) yang merupakan bagian dari studi kasus tunggal. Partisipan dalam studi ini adalah seorang partisipan yang menjalani homecare. Adapun data dikumpulkan dengan melakukan anamnesis kepada partisipan dan menginterpretasikan tanda klinis yang muncul terkait hipernatremia. Data dianalisis menggunakan five analytic techniques. Seorang wanita berusia 48 tahun mengeluhkan sesak napas dan palpitasi setelah mengonsumsi jus celery untuk mengendalikan kadar kolesterol darahnya. Partisipan juga mengeluhkan adanya kelelahan yang juga merupakan tanda dari hipernatremia.  Partisipan diberikan oksigen 3 liter per menit per nasal kanul, larutan gula hangat, air putih dan tiga butir kurma. Setelah dilakukan intervensi, partisipan menunjukkan perbaikan kondisi berupa sesak napas dan dada berdebar-debar menurun. Hal ini menunjukkan kurma dapat dijadikan pertimbangan untuk pertolongan pertama pada hipernatremia di rumah sebelum partisipan mendapatkan penanganan lanjutan di rumah sakit. Penelitian selanjutnya diperlukan untuk menguji jumlah makanan tinggi kalium yang harus dikonsumsi secara tepat.
Manajemen Perioperatif pada Pasien Hipertensi Pulmonal Akibat Kelainan Jantung Kiri yang Menjalani Operasi Bedah Jantung
Authors: Nur Rifdhani Fakhrudin , Kurniawaty Juni , Pratomo Bhirowo Yudo
Published: September 2023

Hipertensi pulmonal akibat kelainan jantung kiri (PH-LHD) pada pasien yang menjalani bedah jantung dihubungkan dengan tingginya komplikasi, peningkatan risiko luaran buruk, dan kenaikan mortalitas perioperatif. Manajemen praoperatif pada pasien PH-LHD meliputi anamnesis, pemeriksaan fisik, pemeriksaan penunjang, serta kateterisasi jantung kanan untuk menegakkan diagnosis definitif. Optimalisasi praoperatif dilakukan dengan memastikan kondisi euvolemik, meneruskan pengobatan sebelumnya, sampai memberikan perawatan intensif pada kondisi gagal jantung dekompensasi akut. Selain pemantauan invasif standar, pemantauan transesophageal echocardiography intraoperatif digunakan untuk menganalisis PH dan mengenali kelainan jantung kiri yang menyebabkan PH. Induksi anestesi dilakukan dengan teknik anestesi balans antara opioid dan agen inhalasi dosis rendah. Pada PH-LHD yang disebabkan lesi katup, target hemodinamik disesuaikan dengan jenis kelainan katupnya. Target manajemen pascaoperatif adalah menghindari dan mengobati gagal ventrikel kanan dengan mengatasi aritmia, melakukan strategi ventilasi mekanik pelindung ventrikel kanan, memastikan keseimbangan cairan, dan memberikan dukungan obat vasoaktif jika diperlukan.
Tatalaksana Anestesi pada Ebstein’s Anomaly yang menjalani Cone Procedure
Authors: Lopulalan Mahendra Dwi Aditya , Nugroho Budi
Published: September 2023

Latar Belakang: Ebstein’s anomaly adalah kelainan kongenital yang ditandai dengan malformasi dan perpindahan apikal dari daun katup trikuspid. Pasien datang dengan rentang umur yang luas dari neonatus hingga dewasa dengan berbagai presentasi klinis mulai dari asimtomatik hingga gagal jantung, sianosis, dan aritmia paroksismal. Anomali ini kompleks dan bervariasi yang dapat dikelola dengan berbagai teknik koreksi bedah.Kasus: Seorang wanita berusia 30 tahun datang ke rumah sakit dengan keluhan mudah lelah dan pingsan sejak kecil. Dari pemeriksaan ekokardiografi ditemukan trikuspid regurgitasi berat yang sesuai dengan Ebstein’s anomaly dan atrial septal defect (ASD). Pasien dinilai dengan status fisik ASA 4 dan dilakukan cone procedure.Diskusi: Konsekuensi hemodinamik dan implikasi anestesi pada koreksi Ebstein’s anomaly sangat menantang. Manajemen anestesi yang komprehensif diperlukan untuk, mengatasi masalah yang disebabkan oleh trikuspid regurgitasi, atrialisasi ventrikel kanan, atrial septal defek, gangguan jalur konduksi, dan pada sebagian pasien disfungsi ventrikel kiri akibat geometri yang abnormal.Kesimpulan: Ahli anestesiologi harus merencanakan strategi perioperatif yang tepat untuk mendapatkan hemodinamik yang optimal selama prosedur perbaikan Ebstein’s anomaly dan memfasilitasi pemulihan untuk mengurangi morbiditas dan mortalitas.
Managing Diversity Through Human Resource Management: A USA Perspective and Conceptual Framework
Authors: Hossain Mohammad Ikbal
Published: September 2023

This research paper explores the dynamic landscape of managing diversity through Human Resource Management (HRM), focusing on the United States context. Evolving from a compliance concern to a strategic imperative, diversity plays a pivotal role in enhancing innovation, creativity, and problem-solving in contemporary workplaces. By aligning HRM practices with diversity initiatives, organizations can leverage the strengths of a heterogeneous workforce. The challenges posed by communication barriers, stereotypes, and resistance to change necessitate a strategic HRM approach. Tailored recruitment, training, performance management, and leadership development are key elements of this approach. Creating an inclusive organizational culture, facilitated by HRM through leadership commitment, anti-discrimination policies, and open communication, is pivotal. Legal and ethical considerations provide a foundation for this journey. The potential long-term benefits of effective diversity management include improved performance, innovation, talent attraction, and social responsibility. This paper underscores the importance of managing diversity through HRM as an investment in organizational success and a more inclusive society.
Bridging the Gap or Widening the Divide? The Role of Technology in Global Economic Inequality
Authors: Eshehri Abdulrhman , Alsoaery Abdulrhman
Published: September 2023

This article explores the relationship between technological advancements, transnational capitalism, and the growing divide in global economic inequality. It analyzes how developed nations' dominance in technology research and innovation has contributed to the disproportionate distribution of wealth, productivity, and economic development. By examining data such as G7 countries' investments in research and development, accounting for over 88% of global expenditure, and their holding of over 90% of patents filed in 2014, the article highlights the intricate links between multinational corporations, technological diffusion, and global inequality. The findings reveal that the concentration of technological advancements in a few developed countries not only fuels global capitalism but also exacerbates the economic disparities between rich and poor nations. The article calls for a more equitable approach to technological development and diffusion to bridge this widening gap.
Die Ambiguität von begrifflichen und gegenständlichen Merkmalen in der theoretischen Philosophie Kants
Authors: Grohmann Till
Published: September 2023

This paper deals with the concept of ‘mark’ (or character, in German Merkmal) in Kant’s theoretical philosophy. It examines the question of what marks are for Kant: Are they marks of things or of our thinking? Are they ontic object marks or conceptual marks? Are marks ontological or logical in nature? We will see that in Kant’s philosophy, as well as in the thought of his rationalist predecessors, the concept of the mark is embedded in a peculiar ambiguity in that it stands for both objective qualities and conceptual representations. – In a first step we will trace the ambiguity of the mark in Kant’s predecessors and contemporaries (especially in Meier, Wolff and Leibniz). In a second step, we will show that Kant retains the aforementioned ambiguity in terms of wording but overcomes it in terms of content.
„Ein unbegreiflich zahlreiches Sternenheer“ – Eine Kupfertafel, ergänzend zu Kants Maupertuis-Rezeption in der NTH (1755)
Authors: Walter Martin
Published: September 2023

In his Treatise on the Figure of the Stars (1732), Maupertuis described bright and elliptic phenomena in the night sky. Based on Maupertuis’s account of these astronomical observations, Kant developed an explanation of his own in his early book on the Universal Natural History and Theory of the Heavens (1755). For him, these figures were seemingly stars, suns and even whole galaxies, subsystems orbiting a central body or a central sun, held by Kant to be the middle of the universe and a whole, an immense and immeasurable system of many uncountable solar systems. Since Kant did not read Maupertuis’s treatise, he derived his knowledge from a review of the Collected Essays of Maupertuis, in which the Treatise was published (1744). This review appeared in the Nova Acta Eruditorum in April 1745. Alongside this known source, another possible and complementary source on Maupertuis’s theory may have influenced Kant in his thinking: Gottsched’s philosophical textbook First Elements of all Philosophical Disciplines (5th edition, Theoretical part, Vol. I, 1748). The plate beneath the front matter of this book shows a picture of many solar systems. It depicts in detail, and according to Maupertuis’s account, comets signifying the center of different solar systems by the alignment of their tails, pointing in the opposite direction of the center. Gottsched’s book was known to Kant, who mentioned it in at least three lectures on logic. In addition, it was widely read in Königsberg’s intellectual and academic circles, since Gottsched was born not far from Königsberg and was a friend of Knutzen, Flottwell, Scheffner, the Imperial Countess of Keyserlingk, and others.
An Eye for Physics
Authors: Acarlı Dilek Sultan
Published: September 2023

In this article, a guide is presented to help biology teachers so that they can process the subject of the eye and eye defects with an interdisciplinary approach. The guide, which was created by considering the stages of a lesson plan, includes content information, suggestions, and various directions that can help the teacher at every stage. The presented content is arranged to guide students from time to time to remind them of some concepts and subjects they learned in physics lessons while processing the structure of the eye and eye defects. In this way, it is aimed that the students can perceive the information they learned in physics and biology lessons holistically and see the relationships and connections more easily. Thus, it is thought that this situation will also benefit their meaningful learning and the permanence of knowledge.
A Profound Edge
Authors: Sheppard Samantha N.
Published: September 2023

This essay examines the New Negress Film Society, a collective of Black women and non-binary filmmakers who create community, spaces, and films that reimagine cultural productions that have traditionally exploited Black communities. Founded in 2013, the genesis and evolution of the New Negress Film Society reveals the individual, institutional, and industrial challenges that impact Black women’s filmmaking as well as the ways in which black feminist community engenders collectivizing. Samantha Sheppard considers broader traditions of formal and informal black feminist social movements and film collective practice while drawing attention to how New Negress Film Society operates deliberately on the margins and counter to industry-focused and mainstream routes for black cinema.
Bodies that Persist
Authors: Ramírez-Soto Elizabeth
Published: September 2023

This essay by Elizabeth Ramírez-Soto, co-editor of the Special Focus section “Chilean Film and Media: Fifty Years Later (1973/2023),” discusses the nonfiction responses to the 2019 estallido social (social uprising) as part of a longer history of documentary resistance. Ramírez-Soto argues postdictatorship Chilean documentary oscillates between an emphasis on the bodies of the direct victims of state-sanctioned violence and an emphasis on the bodies of the films themselves as haptic images. Focusing on the work of the anonymous group Colectivo Cinematográfico Pedro Chaskel (CCPCH), one of the many collectives that took to the streets to document the popular revolt in 2019, Ramírez-Soto reveals how through the recycling of militant documentaries, these films establish a link with the past and with its images of resistance.
He Insists! From Apprentice Editor to Elder Statesman of the Black Documentary Tradition
Authors: Luckett Josslyn
Published: September 2023

FQ contributing editor Josslyn Luckett speaks with Sam Pollard about his long career, which spans collaborations as an editor with Spike Lee to producing and directing his own documentaries, histories of black independent media, and his most recent film Max Roach: The Drum Also Waltzes.
Aesthetic Wit(h)nessing in Anti-lynching Songs by Silvestre Revueltas and Carlos Chávez
Authors: Stallings Stephanie N.
Published: September 2023

Mexican composers Silvestre Revueltas and Carlos Chávez each wrote one song that execrates the lynching-murder of Black persons in the United States. In them, the composers pit a Mexican aesthetics of death against violent spectacle and social inequities to assert a universal dignity of life and to situate an antiracist position within the context of a broader international class struggle. In the process of airing fresh interpretations of the songs, I imply that the composers’ divergent experiences in the United States—Chávez’s relative proximity to establishment structures of power and Revueltas’s intimacy with working-class struggle and race-based discrimination—informed their translation of Black suffering into the (differently historically colonized) context of Mexico. Both composers effected an artful indirection: a displaced deictic center from which to mediate their social thought concerning Mexico’s own problems of penal excess and extrajudicial lynching. Bracha Ettinger’s aesthetically activated Matrixial dimension sets a theoretical and analytical stage for an exploration of these anti-lynching songs and offers a way of understanding aesthetic expressions of allyship in a transhistorical mode.
Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins
Authors: Sigrist Stephan J , Haucke Volker
Published: September 2023

Compartmentalization by membranes is a common feature of eukaryotic cells and serves to spatiotemporally confine biochemical reactions to control physiology. Membrane‐bound organelles such as the endoplasmic reticulum (ER), the Golgi complex, endosomes and lysosomes, and the plasma membrane, continuously exchange material via vesicular carriers. In addition to vesicular trafficking entailing budding, fission, and fusion processes, organelles can form membrane contact sites (MCSs) that enable the nonvesicular exchange of lipids, ions, and metabolites, or the secretion of neurotransmitters via subsequent membrane fusion. Recent data suggest that biomolecule and information transfer via vesicular carriers and via MCSs share common organizational principles and are often mediated by proteins with intrinsically disordered regions (IDRs). Intrinsically disordered proteins (IDPs) can assemble via low‐affinity, multivalent interactions to facilitate membrane tethering, deformation, fission, or fusion. Here, we review our current understanding of how IDPs drive the formation of multivalent protein assemblies and protein condensates to orchestrate vesicular and nonvesicular transport with a special focus on presynaptic neurotransmission. We further discuss how dysfunction of IDPs causes disease and outline perspectives for future research.
Ultrasound measurement of vastus lateralis and vastus medialis muscle parameters to identify chronic thyrotoxic myopathy
Authors: Fu Shi-en , Wang Rou-mei , Liang Xing-huan , Xian Jing , Pan Jie , Chen Xue-lan , Qiu Cheng-cheng , Tang Zhi-ping , Qin Ying-fen , Yang Hai-yan , Huang Li-li , Kuang Ya-qi , Ma Yan , Luo Zuo-jie
Published: September 2023

Introduction

Chronic thyrotoxic myopathy (CTM) is a common, easily neglected complication of hyperthyroidism. There are currently no standard diagnostic criteria for CTM, and the ultrasonic characteristics of CTM-affected skeletal muscle remain unclear. Herein, we aimed to evaluate hyperthyroid patients for CTM by ultrasound and identify ultrasonic muscle parameter cutoffs for CTM diagnosis.

Materials and methods

Each participant underwent ultrasonography. The original (muscle thickness (MT), pennation angle (PA), and cross-sectional area (CSA)) and corrected (MT/height (HT), MT/body mass index (BMI), CSA/HT, and CSA/BMI) parameters of the vastus lateralis and vastus medialis (VM) were evaluated. The diagnostic effectiveness of ultrasound for predicting CTM was determined using receiver operating characteristic (ROC) curve analysis. Our study included 203 participants: 67 CTM patients (18 males, 49 females), 67 non-CTM patients (28 males, 39 females) and 69 healthy controls (20 males, 49 females).

Results

The CTM group had lower muscular ultrasonic and anthropometric parameters, higher thyroid hormone and thyroid-stimulating hormone receptor antibody (TRAb) levels, and a longer duration of hyperthyroidism than the non-CTM group (P < 0.05). The VM-PA, VM-CSA, VM-CSA/HT, and VM-CSA/BMI were lower in females than in males (P < 0.05). Free thyroxine (FT4) and TRAb both showed significant negative correlations with VM-MT, VM-MT/HT, VM-CSA, and VM-CSA/HT (P < 0.05). VM-MT/BMI and VM-CSA/HT, respectively, best predicted male and female CTM (AUC = 0.84, 0.85; cutoff ≤ 0.07, < 4.01).

Conclusion

Ultrasound measurement of muscular parameters, especially in the VM, is a valid and feasible way of diagnosing and characterizing possible CTM in hyperthyroidism.
Enseñanza exploratoria de la geometría con software de geometría dinámica y el aprendizaje del profesorado de matemáticas: Una revisión sistemática
Authors: Gutiérrez-Araujo Rafael Enrique , Pazuch Vinícius
Published: September 2023

[Objetivo] Este artículo analiza la bibliografía relacionada con la investigación de los procesos de formación continua de profesorado de matemáticas, que asume como objeto el aprendizaje docente, el estudio de prácticas de enseñanza exploratoria o los vínculos entre el uso de software de geometría dinámica (SGD) y la formación profesional. [Metodología] Se realizó una metaetnografía de 18 estudios publicados en el período 2001-2021, localizados mediante búsquedas en bases de datos y revistas de educación matemática. El análisis siguió tres etapas: producción de síntesis interpretativas de cada estudio; elaboración de síntesis integradoras, mediante el reconocimiento de convergencias y divergencias, y producción de síntesis finales. [Resultados] En líneas generales, la revisión revela que: (a) la concepción de aprendizaje docente predominante es aquella relacionada con la participación de profesorado en comunidades de práctica; (b) la enseñanza exploratoria es compatible con el uso de SGD, y su promoción en procesos formativos suele tener en cuenta el diálogo entre actividades teóricas y prácticas; y (c) el profesorado que comienza a integrar SGD en el aula tiende a desaprovechar las potencialidades de este artefacto para la enseñanza, debido al surgimiento de situaciones contingentes en el transcurso de la clase o a sus convicciones acerca del uso pedagógico de tecnologías digitales. [Conclusiones] Entre las conclusiones, se tiene que la integración de SGD en el aula puede lograrse significativamente a través de la toma de conciencia progresiva y crítica del profesorado, sobre los saberes pedagógicos que están detrás de la enseñanza exploratoria en tanto práctica docente.
Taller de resolución de problemas no rutinarios para estudiantes de 8 a 9 años: un estudio de caso
Authors: Rodríguez Jara Miguel , Vergara-Gómez Andrea , Mondaca-Saavedra Alejandra , Gregori Huerta Pablo
Published: September 2023

[Objetivo] Caracterizar las heurísticas utilizadas por estudiantes de entre 8 y 9 años, al enfrentar cuatro problemas no rutinarios que promueven el desarrollo del pensamiento aritmético desde dos perspectivas: la distribución de números bajo una condición gráfica y el uso de operaciones aritméticas en el sistema decimal posicional. [Metodología] El análisis incluyó la elaboración de categorías que permitieron caracterizar a priori las heurísticas que podrían surgir en la resolución de los distintos problemas. Estas categorías fueron utilizadas para implementar un enfoque metodológico mixto, con un alcance exploratorio y descriptivo. El análisis cualitativo se realiza través de un estudio de caso que permite identificar desempeños claves a partir de las producciones escritas de los estudiantes. El análisis cuantitativo se realiza a través de un análisis implicativo, que incluye un árbol de similaridad y la identificación de clases significativas. [Resultados] Se evidencia que el uso de heurísticas simples en la resolución de problemas aritméticos no rutinarios favorece la búsqueda de soluciones parciales y se confirma la presencia persistente de algunas características del razonamiento heurístico, como la atención, la reducción y el cambio de supuestos. Además, se identifican relaciones implicativas entre algunas heurísticas que comparten características comunes, según el tipo de problema. [Conclusiones] Los alcances de este estudio ponen de manifiesto que, incluso en respuestas erróneas o incompletas, es posible reconocer procesos lógicos de elaboración de respuestas parciales y acercamientos intuitivos, que resultan consistentes con la acción de simplificar o facilitar la búsqueda de una solución.
Sensibilidad de Hydra attenuata e Hydra viridis a los plaguicidas diuron y etoprofos, Costa Rica
Authors: Jones Caroline , Ugalde María Del Rocío , Jiménez Katherine , Mena Freylan , Vargas Seiling
Published: September 2023

[Objetivo] El objetivo fue determinar cuál de las dos especies de hidras (Hydra attenuata o Hydra viridis) resultaba más sensible a dos plaguicidas, para luego usarla como parte de la batería de organismos de prueba del Laboratorio de Estudios Ecotoxicológicos (ECOTOX). [Metodología] Para esto se utilizaron diluciones de dos de los plaguicidas más comúnmente usados en el cultivo de piña en Costa Rica y detectados en muestras de agua: el herbicida diuron y el insecticida etoprofos. Se realizaron bioensayos de toxicidad con cada una de estas sustancias y con una mezcla de estas. Se registró el estado morfológico de las hidras. Además, se evaluaron la concentración de efecto medio (EC50), la concentración letal media (LC50), y las interacciones de toxicidad según tres posibilidades: antagónica, aditiva o sinérgica. [Resultados] La H. attenuata fue la especie más sensible a ambos plaguicidas, con LC50s de 16,84 mg/L y 103,01 mg/L; y EC50s de 4,24 mg/L y 23,74 mg/L para diuron y etoprofos, respectivamente. Mientras tanto la H. viridis tuvo LC50s de 36,94 mg/L y 103,01 mg/L, con EC50s de 13,64 mg/L y 53,12 mg/L, también para diuron y etoprofos, respectivamente. La exposición a la mezcla de plaguicidas solo causó mortalidad a la H. viridis y tuvo efecto sinérgico en ambas especies. [Conclusiones] Estos resultados sugieren que la H. attenuata es la especie más apropiada para la evaluación de efectos de plaguicidas, pero se deben realizar más estudios sobre las interacciones de los contaminantes en mezclas, porque estas pueden modificar su toxicidad para diferentes especies.
Resistencia antimicrobiana en los principales recursos acuícolas de los departamentos de Tumbes, Piura, San Martin y Puno
Authors: Calizaya Carla D , Reátegui Erick H , Silva José C , Velazco Rodolfo , Rodríguez Liliana , Angulo Derly R , Llontop Carlos A , Salcedo Luis A , Villena Carla A
Published: September 2023

[Objetivo] El objetivo fue analizar la resistencia antimicrobiana en la acuicultura peruana. [Metodología] Se realizó un estudio observacional, descriptivo. Se incluyeron muestras de las especies Argopecten purpuratus, Oncorhynchus mykiss, Oreochromis niloticus y Litopenaeus vannamei. Se aislaron bacterias del género Enterococcus spp., Salmonella spp. y Aeromonas spp., y especies de Escherichia coli, Vibrio parahaemolyticus, y Flavobacterium psychrophilum. La resistencia antimicrobiana fue evaluada mediante antibiograma y las muestras resistentes fueron secuenciadas para identificar genes de resistencia antimicrobiana. Se calculó la frecuencia absoluta y porcentual, además, se estimaron los intervalos de confianza de Wald, de Clopper-Pearson, y prevalencia agrupada. [Resultados] Respecto a A. purpuratus, el 22,2 % (IC95%:2,81-60,00) de las muestras de E. coli fueron resistentes a oxitetraciclina. Estas pertenecían al 4,44 % (n=2) de los centros de producción acuícola (CPA). En O. mykiss, el 88,89% (IC95%:51,16-99,72) de las muestras de Enterococcus spp. fueron resistentes a fosfomicina y oxitetraciclina. Estas pertenecían al 12,96 % de los CPA (n=7). En referencia a O. niloticus, el 47,31 % (IC95%: 37,16-57,46) de las muestras de E. coli fueron resistentes oxitetraciclina>ampicilina>cloranfenicol>fosfomicina y azitromicina. Estas pertenecían al 50 % de los CPA (n=19). Además, 89, 36% (IC95 %:80,55-98,18) de las muestras de Enterococcus spp. fueron resistentes a fosfomicina>cloranfenicol y colistina>oxitetraciclina>azitromicina>ampicilina; estas pertenecían al 36,84 % de los CPA (n=14). En L. vannamei, el 87,11 % (IC95%:83,00-91,21) de las muestras de Enterococcus spp. fueron resistentes a fosfomicina>colistina>oxitetraciclina>azitromicina>eritromicina>enrofloxacino> ampicilina>cloranfenicol y estas pertenecían al 100 % de los CPA (n=33). Asimismo, 35,05 % (IC95%: 29,74-40,23) de las muestras de V. parahaemolyticus fueron resistentes a ampicilina>fosfomicina>colistina>oxitetraciclina>azitromicina. Estas pertenecían al 78,79 % (n=26) de los CPA. [Conclusiones] El porcentaje de CPA de O. niloticus y L. vannamei, mostraron mayor resistencia antimicrobiana del estudio.
Improvement of thermal stability and flame retardancy of beech wood fibers using steam explosion and phosphorylation reaction
Authors: Cheng Liangsong , Zhan Tianyi , Vahabi Henri , Ziegler-Devin Isabelle , Antoun Karina , Ju Zehui , Chrusciel Laurent , Lu Xiaoning , Brosse Nicolas
Published: September 2023

An environmentally friendly approach was studied for improving the fire retardancy of beech wood using a steam explosion process coupled with a phosphorylation reaction. Raw beech, steam-exploded, or bleached wood was subjected to phosphorylation employing etidronic acid (HEDP) and urea, and the resulting chemical composition and thermal behavior were analyzed using techniques such as elemental analysis, Fourier transform infrared spectroscopy, ionic chromatography, and pyrolysis combustion flow calorimetry. The thermal performance of beech wood underwent significant enhancements after the steam explosion treatment combined with soda impregnation. It resulted in a striking reduction in heat release rates (HRR), especially its peak (pHRR) and time-to-pHRR (TpHRR) values (from 139.5 W/g and 365 °C to 40 W/g and 247 °C) and an increase in residue from 10.5% to 41.3%. The results demonstrate that the process created a self-extinguishing and non-flammable material that exhibited noteworthy flame retardancy improvement.
Huellas prehistóricas y nuevas pinturas rupestres de embarcaciones en Jimena de la Frontera (Cádiz, España)
Authors: Mendoza Álvarez David
Published: September 2023

Presentamos la descripción preliminar de un hallazgo casual realizado en Jimena de la Frontera (Cádiz, España), que demuestran la existencia de un hábitat costero humano. Gracias a los paralelos de las inmediaciones podemos determinar algunas hipótesis sobre la determinación de cada elemento de los que hablaremos. Nos llama   la atención la aparición de pinturas rupestres rojas y negras con representaciones de embarcaciones del tipo de Laja Alta, también un yacimiento localizado en Jimena de la Frontera, así como numerosas huellas humanas y animales fosilizadas en la roca, en las inmediaciones de un posible altar.
Militia amoris en la literatura acadia, grecolatina y sánscrita
Authors: Morales Harley Roberto
Published: September 2023

El artículo analiza el tópico de la militia amoris bajo sus variantes del amor como una guerra, el amor frente a la guerra y el triunfo del amor. Se trabaja con un corpus de 29 pasajes, extraídos de la poesía amorosa acadia (La amante fiel, ca. 2000-1500 a.e.c.), la elegía amorosa latina (Elegías de Tibulo, Elegías de Propercio, Amores de Ovidio; ca. 50-1 a.e.c.) y la lírica amorosa sánscrita (Centuria de amor de Bhartṛhari, ca. s. IV e.c.; Cien poemas de amor de Amaru, ca. s. VII e.c.; Los cincuenta poemas del amor furtivo de Bilhaṇa, ca. s. XI e.c.). En conclusión, se propone la posibilidad de una influencia acadia en la versión grecolatina del tópico, así como la posibilidad de una subsecuente influencia de la última en la poesía amorosa en lengua sánscrita.
vals de las fuentes históricas en España y Latinoamérica: una metodología en busca de la mujer masona
Authors: Hottinger-Craig Sylvia
Published: September 2023

La membresía masónica femenina, de ritos inclusivos o mixtos no son mencionadas de forma explícita y de ahí la dificultad en identificar las mujeres pertenecientes a dichas órdenes. Este trabajo describe los métodos y las fuentes que posibilitan seguirles la pista. Abarcamos desde las mujeres pertenecientes a las logias artesanales tempranas anteriores a las Constituciones de Anderson hasta las organizaciones más recientes en España y Latinoamérica. Incluimos el organigrama de distintos campos de estudios masónicos del Profesor Ferrer Benimeli para localizar la presencia, las actividades y las características masónicas, siendo una plantilla muy útil para la investigación de la masonería femenina.
Address terms by Singapore Chinese in a multilingual context
Authors: Lee Cher Leng
Published: September 2023

Address terms in the Chinese context have been examined by many researchers. This paper examines address terms used by ethnic Chinese people in the multilingual context of Singapore. This study uses a sociopragmatic approach to gain a broader understanding of how the ethnic Chinese population in Singapore chooses between different languages and terms of address in different settings. It seeks to understand the underlying factors that affect one’s decision given the complex linguistic environment. The findings show that there is a diglossia situation in Singapore – a distinction between formal and informal settings (Keshavarz, 2001). In formal settings, only English and Mandarin are used, while southern Chinese dialects are used in informal settings such as with family, friends or in coffee shops. Other factors that affect terms of address include Confucian ethics of showing respect for one’s elders and people of higher positions and status as seen in Gu (1990), and in gaining favour with addressees such as sellers appealing to their customers (Liu, 2009).
La autonomía de las confesiones religiosas. Aportes desde el derecho de la Unión Europea
Authors: Palomino-Lozano Rafael
Published: September 2023

Recientemente, la autonomía de los grupos religiosos se ha visto fuertemente contestada frente a los llamados derechos sexuales y frente a las exigencias de la igualdad y no discriminación. Esta circunstancia invita a un estudio acerca del significado, contenido y fundamento de la autonomía de los grupos religiosos, analizando su virtualidad en el derecho de la Unión Europea.
DCNN-based embedded models for parallel diagnosis of ocular diseases
Authors: Al Jbaar Mamoon A , Dawwd Shefa A.
Published: September 2023

An automated system for detecting ocular diseases with computer-aided tools is essential to identify different eye disorders through fundus pictures. This is because diagnosing ocular illnesses manually is a complicated, time-consuming, and error-prone process. In this research, two multi-label embedded architectures based on a deep learning strategy were proposed for ocular disease recognition and classification. The ODIR (Ocular Disease Intelligent Recognition) dataset was adopted for those models. The suggested designs were implemented as parallel systems. The first model was developed as a parallel embedded system that leverages transfer learning to implement its classifiers. The implementation of these classifiers utilized the deep learning network from VGG16, while the second model was introduced with a parallel architecture, and its classifiers were implemented based on newly proposed deep learning networks. These networks were notable for their small size, limited layers, speedy response, and accurate performance. Therefore, the new proposed design has several benefits, like a small classification network size (20 % of VGG16), enhanced speed, and reduced energy consumption, as well as the suitability for IoT applications that support smart systems like Raspberry Pi and Self-powered components, which possess the ability to function as long as a charged battery is available. The highest accuracy of 0.9974 and 0.96 has been obtained in both proposed models for Myopia ocular disease detection and classification. Compared to research that had been presented in the same field, the performance accuracy of each of the two models shown was high. The P3448-0000 Jetson Nano Developer Kit is used to implement both of the proposed embedded models