bluuebunny/crossref_metadata_2025 huggingface dataset:
One‐year followup of patients with osteoarthritis of the knee who participated in a program of supervised fitness walking and supportive patient education
Authors: Sullivan Theresa , Allegrante John P. , Peterson Margaret G. E. , Kovar Pamela A. , MacKenzie C. Ronald
Published: February 2007

Objective. To determine whether gains in functioning observed immediately following participation in an 8‐week program of supervised fitness walking for patients with knee osteoarthritis were sustained at 1‐year followup.

Methods. Twenty‐nine (61.1%) of 47 original intervention program patients and 23 (51.1%) of 45 original control patients were interviewed by telephone at 1‐year followup. Patients completed the Arthritis Impact Measurement Scales physical activity, arthritis impact, pain, medication use, and general health perceptions subscales, as well as a separate visual analog pain scale and measures of perceived self‐efficacy to cope with arthritis pain and other symptoms.

Results. Adherence to walking was low, and there were no statistically significant differences between intervention and control patients at one year.

Conclusions. The failure of intervention patients to maintain regular walking resulted in loss of functional benefits that were observed at 8 weeks in the original study. Long‐term adherence to walking is critical to maintenance of initial gains in functional outcomes.
What do self‐administered joint counts tell us about patients with rheumatoid arthritis?
Authors: Escalante Agustín
Published: February 2007

Objective. This report presents data from two sources showing that a self‐administered joint count (SAJC) suitable for use in clinical settings provides information comparable with that of observerassessed joint counts.

Methods. Patients were tested with a 1‐page form containing a 40‐joint mannequin on which they could mark their painful or swollen joints. The first sample of 110 patients was used to compare the SAJC with the tender or swollen joint counts (TJC or SJC) performed by a rheumatologist and to a battery of clinical and laboratory measurements. The second sample consisted of 240 rheumatoid arthritis (RA) patients enrolled in a cohort study of RA outcomes, in whom the relationship between the SAJC and health‐related quality of life measures was examined.

Results. Test‐retest reliability of the SAJC was excellent (ri = 0.89), as was its agreement with the observer‐assessed TJC (ri = 0.78). The SAJC was significantly correlated (P ≤ 0.01) to pain on a 10‐point scale (r = 0.33), the McGill Pain Questionnaire (r = 0.27), the pain subscale of the Arthritis Impact Measurement Scales (AIMS) (r = 0.32), the duration of morning stiffness (r = 0.27), and to the AIMS subscales of physical function (r = 0.20), impact (r = 0.31), and global health (r = 0.29). The SAJC was inversely related to formal education (r = −0.32), but did not correlate significantly with the modified Health Assessment Questionnaire, walking velocity, grip strength, or erythrocyte sedimentation rate. The responsiveness of the SAJC was comparable with that of other measures commonly employed to assess RA outcomes. Either the SAJC or the TJC could be included alternatively in multivariate models to explain 7 of the 8 subscales of the Medical Outcomes Study Short Form‐36 (SF‐36) questionnaire.

Conclusion. The SAJC is a reliable and responsive measure that agrees highly with the observer‐assessed TJC and is significantly associated to the health‐related quality of life of patients with RA. Given its low cost and ease of administration, it is suggested that SAJC be included in future studies of RA outcome in routine clinical practice.
The economic cost of musculoskeletal disorders in Canada
Authors: Coyte Peter C. , Asche Carl V. , Croxford Ruth , Chan Ben
Published: February 2007

Objective. This study estimated the total cost of musculoskeletal disorders for Canadians in 1994 and assessed the sensitivity of these cost estimates to variations in the definition of musculoskeletal disorders.

Methods. Disease‐related costs, from a societal perspective, were measured using a prevalencebased analysis. First, direct treatment costs, including expenditures on hospitals and other institutions, physicians and other health professionals, drugs, research, and other items were assessed. Second, indirect costs associated with lost (or foregone) productivity due to disability and premature mortality were evaluated using the human capital approach.

Results. The total cost of musculoskeletal disorders in Canada was $25.6 billion (in 1994 Canadian dollars, $1.00 CDN ≈ $0.75 US) or 3.4% of the gross domestic product. Direct and indirect costs were estimated at $7.5 billion and $18.1 billion, respectively. Lower and upper bound estimates of the total cost of musculoskeletal disorders, derived from the sensitivity analysis, were $19.9 billion and $30.8 billion, respectively. Wide variations were reported in the total cost of various musculoskeletal disorder subcategories, with the highest costs reported for injuries ($10.7 billion), back and spine disorders ($8.1 billion), and arthritis and rheumatism ($5.9 billion).

Conclusions. The economic cost of musculoskeletal disorders was substantial and was sensitive to the definition of musculoskeletal disorders and other underlying assumptions. The hallmark of this study was the variation between subcategories in their cost, pattern of health resource use, and sequelae. The cost estimates may provide guidance in setting priorities for research and prevention activities.
The effects of social support and education on health care costs after three years
Authors: Cronan Terry A. , Hay Meghan , Groess Erik , Bigatti Silvia , Gallagher Ruth , Tomita Mitsuo
Published: February 2007

Objective. To determine whether experimentally developed social support, education about appropriate use of the health care system, and their combination are effective in reducing health care costs for people with osteoarthritis at a 3‐year followup assessment.

Method. Three hundred sixty‐three health maintenance organization members with osteoarthritis were randomly assigned to 1 of 3 intervention groups or to a control group. Two hundred fifty‐six participants completed the 3‐year assessment. Health status and health care use were assessed upon entering the study, and after 1, 2, and 3 years.

Results. Health care costs in the combined experimental groups were lower than those in the control group by $1,279/participant/year in year 3. There were no significant changes in health status between participants' entry into the study and the year 3 assessment. The 3 interventions had nearly equal effects on health status and health care costs. Implementation costs were least for the social support intervention, but the group that combined education and social support had less attrition and greater persistence.

Conclusion. Interventions that target appropriate use of the health care system can be highly costeffective without adversely affecting health status.
Cross‐cultural adaptation and validation of an argentine Spanish version of the Stanford childhood health assessment questionnaire
Authors: Moroldo Marta B. , Cunto Carmen De , Hübscher Osvaldo , Liberatore Diana , Palermo Rosa , Russo Ricardo , Giannini Edward H.
Published: February 2007

Objectives. To translate into Argentine Spanish and cross‐culturally adapt the Childhood Health Assessment Questionnaire (CHAQ) and validate the adapted instrument in Argentine patients with juvenile rheumatoid arthritis (JRA).

Methods. Five bilingual Argentine pediatric rheumatologists translated into Argentine Spanish and cross‐culturally adapted the United States English CHAQ. Pretesting was done in a sample of 23 parents using a probe question technique. Parents of 70 patients with JRA and 21 healthy children (controls) participated in the validation phase. All were from Argentina.

Results. The mean disability index (DI) scores for patients with systemic, polyarticular, or pauciarticular onset JRA were 0.64, 0.32, and 0.1, respectively. Healthy controls averaged 0.2. Intercomponent correlations were between 0.4 and 0.9, suggesting internal consistency, but also some redundancy. Test‐retest reliability, studied at a 1‐week interval, was moderate (mean DI 0.44 [in clinic] and 0.29 [one week later], Pearson's correlation = 0.82). We compared CHAQ scores from 15 parents with those of their children >10 years of age. Significantly higher DI scores were given by patients than their respective parents (P > 0.019), but the pairwise scores (parent–patient) were highly correlated (r = 0.986).

Conclusions. Cross‐cultural adaptation of the US CHAQ to Argentina required few changes. Although DI scores for all patient subgroups were higher than for controls subjects, the scores were low, particularly for those with pauciarticular disease. Prospective studies designed to examine the sensitivity to change and predictive validity will help to assess further the usefulness of the adapted CHAQ in the Argentine population.
Substance use among adolescents with juvenile rheumatoid arthritis
Authors: Nash Alisa A. , Britt Maria T. , Lovell Daniel J. , Passo Murray H. , Rosenthal Susan L.
Published: February 2007

Objective. To determine the prevalence of substance use among adolescents with juvenile rheumatoid arthritis and to assess available opportunities for rheumatologists to identify high risk teens.

Methods. Fifty‐two teens (mean age 13.9 years, 86% female) completed questionnaires regarding substance use (alcohol, tobacco, marijuana, and other illicit substances), functional disability, and frequency of health care contacts.

Results. Alcohol use was reported by 30.7% of teens, including 23.5% of those for whom methotrexate was prescribed; 15.4% reported tobacco use in the last year, and 13.4% reported other illicit substance use in their lifetime, although most use was experimental. No teen reported marijuana use. The majority reported regular contact with their rheumatologist but only 26.9% were ever interviewed alone.

Conclusion. Many teens with juvenile rheumatoid arthritis, including those prescribed methotrexate, used substances, especially alcohol. When rheumatologists see adolescents, particularly in situations where methotrexate may be prescribed, a clinical setting conducive to confidentiality, physician comfort in asking about sensitive topics such as substance abuse, and referral relationships with skilled adolescent health and substance abuse counseling providers are essential.
Differential responses by psychosocial subgroups of fibromyalgia syndrome patients to an interdisciplinary treatment
Authors: Turk Dennis C. , Okifuji Akiko , Sinclair J. David , Starz Terence W.
Published: February 2007

Objectives. To evaluate differential treatment responses among 3 empirically derived, psychosocial subgroups of patients with fibromyalgia syndrome to a standard interdisciplinary treatment program.

Method. Patients were classified into 1 of 3 psychosocial groups on the basis of their responses to the Multidimensional Pain Inventory. Forty‐eight patients completed a 6 one–half‐day outpatient treatment program consisting of medical, physical, occupational, and psychological therapies spaced over a period of 4 weeks (3 sessions the first week followed by 1 session per week for the next 3 consecutive weeks).

Results. Statistically significant reductions were observed in pain, affective distress, perceived disability, and perceived interference of pain in the patients characterized by poor coping and high level of pain (“dysfunctional” group). In contrast, individuals who were characterized by interpersonal difficulties (“interpersonally distressed” group) exhibited poor responses to the treatment. “Adaptive copers,” the third group, revealed significant improvements in pain but due to low pretreatment levels of affective distress and disability showed little improvement on these outcomes.

Conclusions. The results provided support for the hypothesis that customizing treatment based on patients' psychosocial needs will lead to enhanced treatment efficacy. They also emphasize the importance of using appropriate outcome criteria, as low levels of problems at baseline are not likely to show significant changes following any treatment.
Use of alternative therapies by patients with rheumatic disease in Guadalajara, Mexico: Prevalence, beliefs, and expectations
Authors: Ramos‐Remus Cesar , Gamez‐Nava Jorge I. , Gonzalez‐Lopez Laura , Skeith Kenneth J. , Perla‐Navarro Ana V. , Galvan‐Villegas Federico , Suarez‐Almazor Maria E.
Published: February 2007

Objective. To assess the prevalence, practices, beliefs, and expectations of patients with rheumatic diseases in relation to the use of alternative therapies.

Methods. We conducted a cross‐sectional survey of 300 consecutive patients with rheumatic diseases at 3 outpatient rheumatic disease clinics in Guadalajara, Mexico to evaluate the use of alternative therapies. A face‐to‐face structured interview was administered by a trained assistant to evaluate the prevalence of use and patient beliefs, perceptions, and expectations in relation to alternative therapies.

Results. Two hundred fifty patients (83%) had used a total of 1,386 alternative therapies (range 1–19); 203 (68%) patients had used alternative therapy in the previous 12 months. Sixty‐one percent received at least one alternative treatment before the first rheumatology consultation, but an additional 18% initiated these therapies after their initial contact with a rheumatologist at our clinics. Only 66 (26%) of the patients using alternative therapy notified their rheumatologist about their use. Thirty‐six patients (14%) discontinued formal treatment at least on one occasion in order to receive alternative therapies, and only 8 (22%) notified their rheumatologist. Alternative therapy practitioners recommended discontinuation of conventional therapy on 57% of the occasions when formal treatments were discontinued. Mean expenditures per patient for fees to alternative therapy providers were equivalent to 28 days of the official minimum daily wage, and per patient costs for the remedies themselves were equivalent to 13 days of the official minimum daily wage.

Patients who used alternative therapy in the past 12 months had lower education (7 versus 10 years, P > 0.001) and were slightly more disabled (1.7 versus 1.5, modified Health Assessment Questionnaire, P > 0.01).

Conclusions. In this survey most patients used alternative therapies for the treatment of their rheumatic disease. Alternative therapies were costly and appeared to decrease adherence to conventional therapy. Health care providers should openly discuss the use of alternative therapy in patients with rheumatic diseases.
Phosphorylation‐Induced Conformational Changes in Short Peptides Probed by Fluorescence Resonance Energy Transfer in the 10 Å Domain
Authors: Sahoo Harekrushna , Nau Werner M.
Published: February 2007

Phosphorylation‐induced conformational changes in short polypeptides were probed by a fluorescence resonance energy transfer (FRET) method by employing a short‐distance FRET pair (R0≈10 Å) based on tryptophan as natural donor and a 2,3‐diazabicyclo[2.2.2]oct‐2‐ene‐labeled asparagine (Dbo) as synthetic acceptor. Two substrates for kinases, LeuArgArgTrpSerLeuGly‐Dbo (peptide I) and TrpLysArgThrLeuArgArg‐Dbo (peptide II), were investigated, with serine and threonine, respectively, as phosphorylation sites. Steady‐state and time‐resolved fluorescence experiments in H2O revealed a decrease in FRET efficiency for peptide I and an increase for peptide II; this suggested that the effective distances between donor and acceptor increased and decreased, respectively. The same trends and similar absolute variations in effective donor–acceptor distances were observed in propylene glycol, a less polar and highly viscous solvent; this suggested that the variations are due to intrinsic structural preferences. Fitting of the time‐resolved decay traces according to a distribution function model (Gaussian distribution) provided the mean donor–acceptor distances, which showed an increase upon phosphorylation for peptide I (from 9.7 to 10.5 Å) and a decrease for peptide II (from 10.9 to 9.3 Å) in H2O. The broadness (half‐width) of the distributions, which provides a measure of the rigidity of the peptides, remained similar upon phosphorylation of peptide I (3.0 versus 3.1 Å), but decreased for peptide II (from 3.1 to 0.73 Å in H2O); this suggests a more compact, structured conformation upon phosphorylation of the latter peptide. The elongation of the peptide backbone (by ca. 0.7 Å) for peptide I is attributed to an increase in steric demand upon phosphorylation, which favors an extended conformation. The contraction (by ca. 1.4 Å) and structural rigidification of peptide II is attributed to attractive Coulombic interactions and hydrogen bonding between the phosphate group and the arginine residues.
Twisting of Conjugated Oligomers and Polymers: Case Study of Oligo‐ and Polythiophene
Authors: Zade Sanjio S. , Bendikov Michael
Published: February 2007

Interring twisting (change in the dihedral angle between conjugated rings) of polythiophene was studied theoretically using periodic boundary conditions (PBC) at the B3LYP/6‐31G(d) level. We find that the band gap of polymers is strongly dependent on the interring twist angle; yet twisting requires very little energy. A twist of 30° increases the band gap by 0.75 eV in polythiophene, while requiring only 0.41 kcal mol−1 per monomer unit. Such a small energetic value is of the order of crystal packing or van der Waals forces. These results are compared with calculations performed on model oligomers. Sexithiophene, its radical cations, and its dication are optimized at 0–180° end‐to‐end twist angles (which correspond to 0–36° interring dihedral angles) using the B3LYP/6‐31G(d) method. The theoretical results suggest that the HOMO–LUMO gap, ionization potential, and charge distribution of oligomers are strongly dependent on twisting, whereas, similar to the case of polythiophene, twisting of neutral oligothiophenes costs very little energy. In the case of the radical cation, the lowest energy transition is shifted to a longer wavelength region on twisting, while the second‐lowest energy transition is shifted to a shorter wavelength region. This implies that twisted, doped conducting polymers (modeled here by an oligomer radical cation), in contrast to planar, doped polymers, should be transparent within a certain optical window (in the far‐visible region, at ≈1.5 eV). This observation is explained on the basis of changes in the shape and overlap of the frontier molecular orbitals.
Syntheses of Four‐Membered Metallacyclic Complexes with Nitrosylruthenium and Their Ring‐Opening upon HCl Addition
Authors: Arikawa Yasuhiro , Ikeda Kenta , Asayama Taiki , Nishimura Yoshimasa , Onishi Masayoshi
Published: February 2007

Symmetrically disubstituted bis(3‐hydroxyalkynyl) complex [TpRu{CCCPh2(OH)}2(NO)] (1) (Tp = BH(pyrazol‐1‐yl)3) and unsymmetrically mixed (arylalkynyl)(3‐hydroxyalkynyl) congener [TpRu(CCC6H4Me){CCCPh2(OH)}(NO)] (2) were newly prepared. Treatment of 1 or 2 with p‐toluenesulfonic acid monohydrate was carried out to give unusual four‐membered metallacyclic complexes [TpRu{C(CCPh2)C(O)C(CPh2)}(NO)] (3) and [TpRu{C(CCPh2)C(O)CH(C6H4Me)}(NO)] (5), respectively, as major products. Formation mechanism of 3 and 5 would involve insertion of the generated allenylidene group (RuCCCPh2) into the other RuC(alkynyl) bond, followed by hydration of the resulting α‐alkynylallenyl fragment. With regards to the chemical reactivity of their four‐membered metallacycles, treatment with aq. HCl in MeOH afforded the ring‐opened one‐HCl adducts, [TpRuCl{C(CCPh2)C(O)CHCPh2}(NO)] (7) and [TpRuCl{C(CCPh2)C(O)CH2(C6H4Me)}(NO)] (8). On the other hand, the use of CH2Cl2 and THF as the reaction solvent gave another type of one‐HCl adducts [TpRu{CH(C(Cl)CPh2)C(O)C(CPh2)}(NO)] (9 a/9 b) and [TpRu{CH(C(Cl)CPh2)C(O)CH(C6H4Me)}(NO)] (11 a/11 b) as diastereomeric pairs, still retaining the four‐membered ring structure. Moreover, their kinetically controlled products 9 b and 11 b were treated with aq. HCl to afford the ring‐opened two‐HCl adducts [TpRuCl{C(C(Cl)CPh2)(H)C(O)CHCPh2}(NO)] (10) and [TpRuCl{CH(C6H4Me)C(O)CH2(C(Cl)CPh2)}(NO)] (12), respectively. In 10 and 12, each one RuC bond is cleaved at mutually different positions in the ring. Protonation on the carbonyl group would trigger the formation of 7–12.
New Potential Materials for Infrared Nonlinear Optics. Preparation, Characterization and Optical Transparency of Monometallic and Bimetallic Iodates.
Authors: Phanon Delphine , Bentria Bachir , Benbertal Djamal , Mosset Alain , Gautier‐Luneau Isabelle
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Spinel Cobalt Oxides, Potential Conductive Additives for the Positive Electrode of Ni—MH Batteries.
Authors: Tronel Frederic , Guerlou‐Demourgues Liliane , Menetrier Michel , Croguennec Laurence , Goubault Lionel , Bernard Patrick , Delmas Claude
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrogen Silsesquioxane: A Molecular Precursor for Nanocrystalline Si—SiO2 Composites and Freestanding Hydride‐Surface‐Terminated Silicon Nanoparticles.
Authors: Hessel Colin M. , Henderson Eric J. , Veinot Jonathan G. C.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Syntheses, Structures, and Vibrational Spectroscopy of the Two‐Dimensional Iodates Ln(IO3)3 and Ln(IO3)3(H2O) (Ln: Yb, Lu).
Authors: Assefa Zerihun , Ling Jie , Haire Richard G. , Albrecht‐Schmitt Thomas E. , Sykora Richard E.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Triphasic Liquid Systems: Generation and Segregation of Catalytically Active Pd Nanoparticles in an Ammonium‐Based Catalyst‐Philic Phase.
Authors: Perosa Alvise , Tundo Pietro , Selva Maurizio , Canton Patrizia
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Induction in Copper(I)‐Catalyzed Intramolecular [2 + 2] Photocycloaddition: Synthesis of Enantiopure Cyclobutane Derivatives.
Authors: Sarkar Niladri , Ghosh Subrata
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tandem Semipinacol/Schmidt Reaction Leading to a Versatile and Efficient Approach to Azaquaternary Alkaloid Skeletons.
Authors: Gu Peiming , Zhao Yu‐Ming , Tu Yong Qiang , Ma Yufei , Zhang Fumin
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Microwave Assisted Syntheses of Unsubstituted Cyclic Imides.
Authors: Hijji Yousef M. , Benjamin Ellis
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Selective α‐Bromination of β‐Keto Esters in Reusable PEG‐400 under Mild and Catalyst‐Free Conditions.
Authors: Xie Ye‐Xiang , Tang Shi , Zhu Qi‐Ming , Yin Du‐Lin , Li Jin‐Heng
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dicyano‐Functionalized MCM‐41‐Supported Palladium Complex as an Efficient Catalyst for Allylation of Aldehydes and Ketones.
Authors: Zhao Hong , Cai Ming‐Zhong
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Phase‐Transfer Catalysis of Homo‐ and Heterochiral Quaternary Ammonium Salts: Development and Application of Conformationally Flexible Chiral Phase‐Transfer Catalysts.
Authors: Ooi Takashi , Uematsu Yukitaka , Kameda Minoru , Maruoka Keiji
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Active Carbene Ruthenium Catalyst for Metathesis of 1‐Hexene.
Authors: Bai Chen‐Xi , Zhang Zhi‐Qiang , Lue Xiao‐Bing , He Ren , Zhang Wen‐Zhen , Lu Shu‐Lai
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Molecular Tectonics on Surfaces: Bottom‐Up Fabrication of 1D Coordination Networks that Form 1D and 2D Arrays on Graphite
Authors: Surin Mathieu , Samori Paolo , Jouaiti Abdelaziz , Kyritsakas Nathalie , Hosseini Mir Wais
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of N,N‐Dimethylamines via Barbier—Grignard‐Type Electrophilic Amination.
Authors: Erdik Ender , Ates Selma
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dramatic Ligand Effect in Catalytic Asymmetric Reductive Aldol Reaction of Allenic Esters to Ketones.
Authors: Zhao Dongbo , Oisaki Kounosuke , Kanai Motomu , Shibasaki Masakatsu
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
1,5‐Diketone Synthesis Promoted by Barium Hydride or Barium Alkoxides.
Authors: Takahashi Hiroshi , Arai Takayoshi , Yanagisawa Akira
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Multicomponent Approach to Substituted Benzenes Involving Sequential Nickel‐Catalyzed Reactions.
Authors: ElDouhaibi Ahmad Samih , Lozanov Mario , Montgomery John
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Negishi Reaction for Sterically Hindered Couplings: Synthesis of Chiral Binaphthalenes.
Authors: Genov Miroslav , Fuentes Beatriz , Espinet Pablo , Pelaz Beatriz
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Synthesis of δ‐Heteroaryl Substituted β‐Hydroxy‐γ,δ‐unsaturated α‐Amino Acids.
Authors: Cremonesi Giuseppe , Dalla Croce Piero , Fontana Francesco , La Rosa Concetta
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Organocatalytic Epoxidation Using Hypervalent Iodine Reagents.
Authors: Lee Sandra , MacMillan David W. C.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regioselective Entry to Bromo‐γ‐hydroxybutenolides: Useful Building Blocks for Assemblying Natural Product‐Like Libraries.
Authors: Aquino M. , Bruno I. , Riccio R. , Gomez‐Paloma L.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Functionalization of Novel Tetrathia[7]helicenes as New Push—Pull Systems
Authors: Licandro Emanuela , Rigamonti Clara , Ticozzelli Maria Teresa , Monteforte Marco , Baldoli Clara , Giannini Clelia , Maiorana Stefano
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Substituted Dihydroindole Derivatives by Intermolecular Couplings of Samarium Ketyls and Indoles.
Authors: Blot Virginie , Reissig Hans‐Ulrich
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 3‐(Diarylmethylenyl)oxindole by a Palladium‐Catalyzed Domino Carbopalladation/C—H Activation/C—C Bond‐Forming Process.
Authors: Pinto Artur , Neuville Luc , Retailleau Pascal , Zhu Jieping
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Practical Method for the Synthesis of Indolylaryl‐ and Bisindolylmaleimides (V).
Authors: Roy Sudipta , Roy Sujata , Gribble Gordon W.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Unexpected Formation of 2‐Aryl‐3‐benzyl‐1,3‐thiazolidin‐4‐ones.
Authors: Cunico Wilson , Capri Liliane R. , Gomes Claudia R. B. , Sizilio Rosangela H. , Wardell Solange M. S. V.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Synthesis of Bis‐(1,2,4‐triazolyl)‐3‐disulfides
Authors: Liu Tian‐Bao , Jiang Wen‐Qing , Zou Jian‐Ping , Zeng Run‐Sheng
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Pd(II)‐Catalyzed Asymmetric Addition of Malonates to Dihydroisoquinolines.
Authors: Sasamoto Naoki , Dubs Christian , Hamashima Yoshitaka , Sodeoka Mikiko
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ionic Liquid Mediated Knoevenagel Condensation of Meldrum′s Acid and Aldehydes.
Authors: Darvatkar Nitin B. , Deorukhkar Amol R. , Bhilare Sachin V. , Salunkhe Manikrao M.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 6‐[4‐(Allyl/phenyl)‐5‐thioxo‐1,2,4‐triazol‐3‐yl]pyrimidine‐2,4‐diones (II) and Their Reaction with Electrophiles.
Authors: Mekuskiene G. , Vainilavicius P.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Antibacterial Activity of Nitroaryl Thiadiazole‐Levofloxacin Hybrids.
Authors: Foroumadi Alireza , Mansouri Shahla , Emami Saeed , Mirzaei Javad , Sorkhi Maedeh , Saeid‐Adeli Nosratollah , Shafiee Abbas
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Identification of a Novel Boron‐Containing Antibacterial Agent (AN0128) (I) with Antiinflammatory Activity, for the Potential Treatment of Cutaneous Diseases.
Authors: Baker Stephen J. , et al. et al.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Selective Approach to 1,1‐Bis(silyl)‐2‐arylethenes and 1,1‐Bis(silyl)‐1,3‐butadienes via Sequential Silylative Coupling—Heck Coupling Reactions.
Authors: Pawluc Piotr , Hreczycho Grzegorz , Marciniec Bogdan
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Domino Ring‐Closing Enyne‐Metathesis—Cross‐Metathesis Approach to 1‐Phosphonylated Benzazepines.
Authors: Dieltiens Nicolai , Stevens Christian V.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Organocatalytic Highly Enantioselective Synthesis of Secondary α‐Hydroxyphosphonates.
Authors: Dodda Rajasekhar , Zhao Cong‐Gui
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Synthesis of a Chiral Building Block for Cyclopentanoids: A Novel Enantioselective Synthesis of Preclavulone A.
Authors: Zanoni Giuseppe , Porta Alessio , Brunoldi Enrico , Vidari Giovanni
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Total Synthesis and Structure Determination of the Antiherpetic Anthrapyran Antibiotic AH‐1763 IIa.
Authors: Tietze Lutz F. , Gericke Kersten M. , Singidi Ramakrishna Reddy
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Potent Cytotoxic Rocaglamide Derivatives from the Fruits of Amoora cucullata.
Authors: Chumkaew Parinuch , Kato Shigeru , Chantrapromma Kan
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Al—Ni—Pt (Aluminum—Nickel—Platinum)
Authors: Raghavan V.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Al—Mn—Ni (Aluminum—Manganese—Nickel)
Authors: Raghavan V.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High‐Temperature Solid‐Oxide Fuel Cells — New Trends in Materials Research
Authors: Molenda Janina
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of Layered Double Hydroxides
Authors: He Jing , Wei Min , Li Bo , Kang Yu , Evans David G. , Duan Xue
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design and Synthesis of Phosphonodifluoromethyl Phenylalanine (F2Pmp): A Useful Phosphotyrosyl Mimetic
Authors: Burke Terrence R. Jr.
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structural Effects of the Cyclobutyl Group on Reactivity and Properties
Authors: Charton Marvin
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Results on A‐Ring Modification of 1α,25‐Dihydroxyvitamin D3: Design and Synthesis of VDR‐Agonists and Antagonists with High Biological Activity
Authors: Saito Nozomi , Honzawa Shinobu , Kittaka Atsushi
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hybrid Molecules Between Distamycin A and Active Moieties of Antitumor Agents
Authors: Baraldi Pier Giovanni , Preti Delia , Fruttarolo Francesca , Tabrizi Mojgan Aghazadeh , Romagnoli Romeo
Published: February 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Amniotic fluid can act as an appetitive unconditioned stimulus in preweanling rats
Authors: Arias Carlos , Chotro M.G.
Published: February 2007

Studies in humans and animals indicate that exposure to flavors in the amniotic fluid during the later gestational period may induce preferences for those flavors. Considering that during the last prenatal period the amniotic fluid contains substances that activate the opioid system, and that this system plays a critical role in the acquisition of olfactory preferences early in life, it has been hypothesized that the amniotic fluid may acquire appetitive unconditioned properties during this period. This has been tested in an experiment in which preweanling rats were exposed to alcohol odor (CS) paired or unpaired with the intraoral infusion of amniotic fluid (US) collected on gestational day 20. The pairing of these two stimuli induced an enhanced palatability of alcohol's flavor as well an increased intake of the drug. These results support the idea that amniotic fluid acquires appetitive unconditioned properties during the last days of gestation and suggest that associative mechanisms involving the amniotic fluid could be underlying odor and taste preferences acquired through fetal exposure. © 2007 Wiley Periodicals, Inc. Dev Psychobiol 49: 139–149, 2007.
The effect of repetition on imitation from television during infancy
Authors: Barr Rachel , Muentener Paul , Garcia Amaya , Fujimoto Melissa , Chávez Verónica
Published: February 2007

Although television exposure levels during infancy are high, the impact of such exposure on learning is relatively unknown. Initial studies have shown that infants imitate significantly fewer target actions from a televised demonstration than they imitate from a live demonstration. It was hypothesized that increasing the duration of exposure to the videotaped demonstration would increase learning from television. Independent groups of 12‐ to 21‐month‐olds were exposed to live or videotaped demonstrations of target actions, and imitation of the target actions was measured 24 hr later. The video segment duration was twice that of the live presentation. Doubling exposure increased levels of imitation performance in the video groups to that of the live groups, and both groups exceeded baseline performance. These results are consistent with the perceptual encoding impoverishment theory, and we conclude that repeated exposure enhances encoding of the target actions from a 2D television source. © 2007 Wiley Periodicals, Inc. Dev Psychobiol 49: 196–207, 2007.
JNK2 negatively regulates CD8+ T cell effector function and anti‐tumor immune response
Authors: Tao Jian , Gao Yunfei , Li Ming O. , He Weifeng , Chen Liang , Harvev Bohdan , Davis Roger J. , Flavell Richard A. , Yin Zhinan
Published: February 2007

JNK1 and JNK2 have distinct effects on activation, differentiation and function of CD8+ T cells. Our early studies demonstrated that JNK1 is required for CD8+ T cell‐mediated tumor immune surveillance. However, the role of JNK2 in CD8+ T cell response and effector functions, especially in anti‐tumor immune response, is unknown. To define the role of JNK2 in antigen‐specific immune response, we have investigated CD8+ T cells from OT‐1 CD8+ transgenic mice in response to either high‐ or low‐affinity peptides. JNK2–/– CD8+ T cells proliferated better in response to both peptides, with more cell division and less cell death. In addition, JNK2–/– CD8+ T cells produced higher levels of IFN‐γ, which is associated with increased expression of T‐bet and Eomesodermin (Eomes). Moreover, JNK2–/– CD8+ T cells expresses high levels of granzyme B and show increased CTL activity. Finally, the enhanced expansion and effector function of JNK2–/– CD8+ T cells was further evidenced by their capacity to delay tumor growth in vivo. In summary, our results demonstrate that JNK2 negatively regulates antigen‐specific CD8+ T cell expansion and effector function, and thus selectively blocking JNK2 in CD8+ T cells may potentially enhance anti‐tumor immune response.
A Theoretical Study of the Nearest Cu···Cu Antiferromagnetic Exchange Coupling Interactions in [LaCu6] and [YCu6]
Authors: Zhang Yi‐Quan , Luo Cheng‐Lin
Published: February 2007

A density functional study of the exchange coupling interactions between the two nearest CuII centers in [LaCu6] and [YCu6] is presented. Two approaches show that the Cu···Cu antiferromagnetic interactions increase with a decrease of the ionic radius of the diamagnetic central LaIII and YIII ions. However, the influence of the central ions on the Cu···Cu interactions is small compared to that of their structures according to our calculations. We therefore conclude that the stronger antiferromagnetic interactions between the two nearest CuII centers in [LaCu6] than in [YCu6] are not a result of the central LaIII ion but the structure. The antiferromagnetic contributions of the direct overlap between the two nearest CuII magnetic orbitals also play a major role according to the calculations of the overlap integral Sij based on Kahn's theory.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Meroterpenoid Pigments from Albatrellus flettii (Basidiomycetes)
Authors: Koch Barbara , Steglich Wolfgang
Published: February 2007

The pigments responsible for the blue colour of the North American polypore Albatrellus flettii have been isolated and their structures elucidated by spectroscopic methods. Albatrellin, a dimeric meroterpenoid with a furylbenzoquinone chromophore, is accompanied by its 16‐hydroxy and 16‐oxo derivatives. The latter has recently been described as grifolone B from a Japanese collection of A. caeruleoporus. Based on the idea that albatrellin is formed in nature by oxidative coupling of a grifolinquinone with the furan derivative cristatin, the blue pigment was synthesized in vitro. The reaction could be applied to the synthesis of several analogues.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
A combined analytical approach reveals novel EXT1/2 gene mutations in a large cohort of Italian multiple osteochondromas patients
Authors: Signori Emanuela , Massi Emanuela , Matera Maria Giovanna , Poscente Monica , Gravina Carolina , Falcone Gianluca , Rosa Michele Attilio , Rinaldi Monica , Wuyts Wim , Seripa Davide , Dallapiccola Bruno , Fazio Vito Michele ,   Clinical reference groups
Published: February 2007

Multiple osteochondromas (MO), also known as hereditary multiple exostoses (HME), is one of the most common hereditary musculoskeletal diseases in Caucasians (1/50,000) with wide clinical variability and genetic heterogeneity. Two genes have thus far been identified as causing the disease, namely EXT1 and EXT2. Various methods to detect mutations in the EXT genes have been used. Here a cohort of 100 MO patients belonging to unrelated Italian families have been analyzed by single‐strand conformation polymorphism (SSCP) analysis or by denaturing high performance liquid chromatography (DHPLC). However, neither of these techniques can detect deletions or duplications of entire exons. Families that were negative at SSCP/DHPLC analysis underwent two‐color multiple ligation‐dependent probe amplification (MLPA) analysis. By these complementary techniques mutation detection was significantly improved and 26 novel mutations have been revealed as well as 18 previously described mutations to give a total of 44 different mutations. Thus we can conclude that combining MLPA with DHPLC in point‐mutations negative MO families, the detection of mutations in EXT genes can significantly improve the identification of both point‐mutations and mid‐size rearrangements. More important, we were able to characterize all those patients who were negative at the first PCR‐based method screening. © 2007 Wiley‐Liss, Inc.
The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT study
Authors: Bogner Hillary R. , Bruce Martha L. , Reynolds Charles F. , Mulsant Benoit H. , Cary Mark S. , Morales Knashawn , Alexopoulos George S.
Published: February 2007

Objective

To describe the influence of domains of cognition on remission and response of depression in an intervention trial among older primary care patients.

Methods

Twenty primary care practices were randomly assigned to Usual Care or to an Intervention consisting of a depression care manager offering algorithm‐based care for depression. In all, 599 adults 60 years and older with a depression diagnosis were included in these analyses. Depression severity and remission of depression were assessed by the 24‐item Hamilton Depression Rating Scale. The Mini‐Mental State Examination (MMSE) was our global measure of cognitive function. Verbal memory was assessed with the memory subscale of the Dementia Rating Scale. Attention was measured with the digit span from the Weschler Adult Intelligence Test. Response inhibition, one of the executive functions, was assessed with the Stroop Color‐Word test.

Results

The intervention was associated with improved remission and response rates regardless of cognitive impairment. Response inhibition as measured by the Stroop Color‐Word test appeared to significantly modify the intervention versus usual care difference in remission and response at 4 months. Patients in the poorest performance quartile at baseline on the Stroop Color‐Word test in the Intervention Condition were more likely to achieve remission of depression at 4 months than comparable patients in Usual Care [odds ratio (OR) = 17.76, 95% Confidence Interval (CI), 3.06, 103.1].

Conclusions

Depressed older adults in primary care with executive dysfunction have low remission and response rates when receiving usual care but benefit from depression care management. Copyright © 2007 John Wiley & Sons, Ltd.