bluuebunny/crossref_metadata_2025 huggingface dataset:
Asymmetric Synthesis of an Amino Acid Derivative from Achiral Aroyl Acrylamide by Reversible Michael Addition and Preferential Crystallization
Authors: Kaji Yuki , Uemura Naohiro , Kasashima Yoshio , Ishikawa Hiroki , Yoshida Yasushi , Mino Takashi , Sakamoto Masami
Published: September 2016

Single‐handed α‐amino acid derivatives were generated from achiral precursors without an external chiral source. Conjugate addition of phenethylamine to an achiral aroyl acrylamide under homogeneous conditions gave the α‐amino amides in quantitative yields, which crystallized as a conglomerate of a P21 crystal system. Dynamic preferential crystallization or attrition‐enhanced deracemization resulted in the formation of enantiomorphic crystals of 99 % ee.
ChemInform Abstract: Enclathration of X@La4 Tetrahedra in Channels of Zn—P Frameworks in La3Zn4P6X (X: Cl, Br).
Authors: Wang Jian , Kaseman Derrick , Lee Kathleen , Sen Sabyasachi , Kovnir Kirill
Published: September 2016

Phase‐pure polycrystalline La3Zn4P6Cl (I) and La3Zn4P6.6Br0.8 (II) are prepared by solid state reactions of stoichiometric amounts of La, Zn, red P, and anhydrous ZnCl2 (ZnBr2) (glassy carbon crucibles in evacuated silica tubes, 1073 K, 6 d).
ChemInform Abstract: A Deep‐Ultraviolet Nonlinear Optical Crystal: Strontium Beryllium Borate Fluoride with Planar Be(O/F)3 Groups.
Authors: Yu Na , Wang Shichao , Ye Ning , Liang Fei , Lin Zheshuai , Luo Min , Poeppelmeier Kenneth R.
Published: September 2016

Single crystals of Sr3 [(Be0.3B0.7)3B3O10] [Be(O0.7F0.3)3] (I) are grown by spontaneous crystallization of a molten SrO/B2O3/LiF flux using a 3:1:3:5 molar mixture of SrCO3, BeO, B2O3, and LiF (Pt crucible, 950 °C; rapid cooling to 800 °C at a rate of 50 °C/h and further cooling to 700 °C at a rate of 3 °C/h).
ChemInform Abstract: Structural, Magnetic and Theoretical Investigations on the Magnetocaloric Properties of La0.7Sr0.25K0.05MnO3 Perovskite.
Authors: El Kossi S. , Dhahri J. , Hlil E. K.
Published: September 2016

The title compound is synthesized by solid state reaction of La2O3, SrCO3, K2CO3, and MnO2 (calcination at 900—1100 °C, sintering at 1200 °C for 24 h).
ChemInform Abstract: Lithiation‐Driven Structural Transition of VO2F into Disordered Rock‐Salt LixVO2F.
Authors: Chen Ruiyong , Maawad Emad , Knapp Michael , Ren Shuhua , Beran Premysl , Witter Raiker , Hempelmann Rolf
Published: September 2016

Rhombohedral VO2F (space group R$\bar 3$c) is synthesized as a new high capacity/energy density cathode material for rechargeable Li‐batteries by ball‐milling of stoichiometric mixtures of VOF3 and V2O5.
ChemInform Abstract: Visible‐Light‐Responsive CuLi1/3Ti2/3O2 Powders Prepared by a Molten CuCl Treatment of Li2TiO3 for Photocatalytic H2 Evolution and Z‐Schematic Water Splitting.
Authors: Iwashina Katsuya , Iwase Akihide , Nozawa Shunsuke , Adachi Shin‐ichi , Kudo Akihiko
Published: September 2016

CuLi1/3Ti2/3O2 powders with hexagonal and trigonal delafossite structures are prepared by treating cubic Li2TiO3 and monoclinic Li2TiO3 with molten CuCl, resp.
ChemInform Abstract: Nature‐Inspired Design of Artificial Solar‐to‐Fuel Conversion Systems Based on Copper Phosphate Microflowers.
Authors: Wang Jing , Zhu Ting , Ho Ghim Wei
Published: September 2016

Copper phosphate micrometer‐scale flower structures are generated on copper foils by corrosion with phosphoric acid and used as templates for deposition of TiO2 nanoparticles.
ChemInform Abstract: Controllable Doping of Nitrogen and Tetravalent Niobium Affords Yellow and Black Calcium Niobate Nanosheets for Enhanced Photocatalytic Hydrogen Evolution.
Authors: Zhou Yannan , Wen Ting , Guo Yanzhen , Yang Baocheng , Wang Yonggang
Published: September 2016

Yellow N‐doped and black N‐/Nb4+‐doped KCa2Nb3O10 nanosheets with molecular thickness are prepared by liquid exfoliation of layered KCa2Nb3O10 with controllable nitrogen and tetravalent niobium doping.
ChemInform Abstract: Compositional and Structural Versatility in an Unusual Family of anti‐Perovskite Fluorides: [Cu(H2O)4]3 [(MF6)(M′F6)].
Authors: Felder Justin B. , Yeon Jeongho , Smith Mark D. , zur Loye Hans‐Conrad
Published: September 2016

Crystals of the anti‐Perovskites (III), (V), (VIII), (IX), and (X) are hydrothermally prepared with yields greater than 90% and characterized by single crystal XRD, UV/VIS spectroscopy, and magnetic measurements.
ChemInform Abstract: A Theophylline Based Copper N‐Heterocyclic Carbene Complex: Synthesis and Activity Studies in Green Media.
Authors: Szadkowska Anna , Staszko Sebastian , Zaorska Ewelina , Pawlowski Robert
Published: September 2016

The new catalyst is found to be active in alkyne‐azide cycloaddition reactions (CuAAC) leading to compound (III) and Glaser homo‐coupling reactions leading to compound (V) in aqueous media at room temperature.
ChemInform Abstract: Regioselective Intermolecular Diamination and Aminooxygenation of Alkenes with Saccharin.
Authors: Martinez Claudio , Perez Edwin G. , Iglesias Alvaro , Escudero‐Adan Eduardo C. , Muniz Kilian
Published: September 2016

Newly synthesized bissaccharido palladium complexes are investigated as catalysts in the vicinal difunctionalization of terminal alkenes.
ChemInform Abstract: Dodecanoyl Thiosemicarbazide Derivatives as Useful Synthons in the Synthesis of 1,2,4‐Triazole, 1,3,4‐Thiadiazole, and 1,3‐Benzothiazole Derivatives.
Authors: Hemdan Magdy M. , Abou Elmagd Wael S. I. , Samy Sandy S. , Youssef Ahmed S. A.
Published: September 2016

The easily accessible thiosemicarbazide (IIIa) proves to be a useful building block for the synthesis of a variety of heterocycles.
ChemInform Abstract: A Highly Efficient Magnetic Solid Acid Nanocatalyst for the Synthesis of New Bulky Heterocyclic Compounds.
Authors: Nasr‐Esfahani Masoud , Rafiee Zahra , Montazerozohori Morteza , Kashi Hassan
Published: September 2016

Some new bulky heterocycles such as bis(imidazole), bis(pyridine), bis(xanthene), and bis(acridine) are prepared using non‐toxic and environmentally friendly Fe3O4 nanoparticles coated with maleic anhydride‐functionalized aminopropyltriethoxysilane as catalyst.
ChemInform Abstract: Chiral Ferrocene‐Based P,S Ligands for Ir‐Catalyzed Hydrogenation of Minimally Functionalized Olefins. Scope and Limitations.
Authors: Biosca Maria , Coll Merce , Lagarde Florian , Bremond Emma , Routaboul Lucie , Manoury Eric , Pamies Oscar , Poli Rinaldo , Dieguez Montserrat
Published: September 2016

Twelve iridium complexes with planar chiral ferrocenes, e.g. TBSF and DMPF, are prepared and tested as catalysts for the asymmetric hydrogenation of different alkenes.
ChemInform Abstract: Copper‐Catalyzed Aerobic Oxidation of Azinylmethanes for Access to Trifluoromethylazinylols.
Authors: Zheng Gang , Liu Hao , Wang Mang
Published: September 2016

A copper‐catalyzed protocol is presented without the addition of ligands or additives to give aldehydes or trifluoromethylazinylols.
ChemInform Abstract: Highly Active and Robust Metalloporphyrin Catalysts for the Synthesis of Cyclic Carbonates from a Broad Range of Epoxides and Carbon Dioxide.
Authors: Maeda Chihiro , Shimonishi Junta , Miyazaki Ray , Hasegawa Jun‐ya , Ema Tadashi
Published: September 2016

The title reaction is successfully applied to mono‐ and 1,1‐ as well as 1,2‐disubstituted terminal and internal epoxides as well as diepoxides.
ChemInform Abstract: Nickel Boride Mediated Cleavage of 1,3‐Oxathiolanes: A Convenient Approach to Deprotection and Reduction.
Authors: Khurana Jitender M. , Magoo Devanshi , Dawra Kiran
Published: September 2016

A combination of NiCl2 and NaBH4 allows the convenient and efficient deprotection of oxathiolanes to restore the corresponding carbonyl compounds.
ChemInform Abstract: Catalytic Enantioselective Dihalogenation and the Selective Synthesis of (‐)‐Deschloromytilipin A and (‐)‐Danicalipin A.
Authors: Landry Matthew L. , Hu Dennis X. , McKenna Grace M. , Burns Noah Z.
Published: September 2016

A titanium‐based catalytic enantioselective dichlorination of simple allylic alcohols is described.
ChemInform Abstract: Enantioselective Synthesis of syn‐2‐Amino‐1,3‐diols via Organocatalytic Sequential oxa‐Michael/α‐Amination Reactions of α,β‐Unsaturated Aldehydes.
Authors: Weng Jiang , Huang Lin‐Jie , Long Liang , Xu Ling‐Yi , Lu Gui
Published: September 2016

A one‐pot sequential oxa‐Michael/α‐amination reaction through combining iminium and enamine activation of α,β‐unsaturated aldehydes is reported.
ChemInform Abstract: Organocatalytic Enantioselective Transfer Hydrogenation of β‐Amino Nitroolefins.
Authors: Ferraro Antonino , Bernardi Luca , Fochi Mariafrancesca
Published: September 2016

The asymmetric organocatalytic transfer hydrogenation of β‐acetylamino and β‐Boc‐amino nitroolefins is realized in high yields and enantioselectivities using a thiourea catalyst and a Hantzsch ester as hydrogen source.
ChemInform Abstract: Selective Monoarylation of Primary Anilines Catalyzed by Pd(dippf) and Its Application in OLED Component Synthesis.
Authors: Gruenberg Matthias F. , Jia Fan , Rivas‐Nass Andreas , Goossen Lukas J.
Published: September 2016

Pd(dippf) complexes (PDM) are found to promote the monoarylation of primary anilines (I) with unprecedented selectivity.
ChemInform Abstract: Gold Nanoparticles Supported on Polyacrylamide Containing a Phosphorus Ligand as an Efficient Heterogeneous Catalyst for Three‐Component Synthesis of Propargylamines in Water.
Authors: Gholinejad Mohammad , Hamed Fatemeh , Najera Carmen
Published: September 2016

Propargylamines are prepared by three‐component coupling of amines, aldehydes, and phenylacetylene in high yields.
ChemInform Abstract: A Chemoselective ipso‐Hydroxylation of Arylboronic Acids Using Urea‐Hydrogen Peroxide under Catalyst Free Condition.
Authors: Gupta Surabhi , Chaudhary Priyanka , Srivastava Vandana , Kandasamy Jeyakumar
Published: September 2016

Sensitive functional groups such as olefin, aldehyde, alcohol, ketone as well as heterocycles are tolerated under the standard conditions.
ChemInform Abstract: Solvent‐Free Aminocarbonylation of Iodobenzene in the Presence of SILP‐Palladium Catalysts.
Authors: Papp M. , Szabo P. , Sranko D. , Skoda‐Foeldes R.
Published: September 2016

Heterogeneous palladium catalysts prepared by immobilization of palladium on supported ionic liquid phases are effectively used as reusable catalyst for the synthesis of carboxylic amides.
ChemInform Abstract: Chromatography‐Free Esterification Reactions Using a Bifunctional Polymer.
Authors: Ma Shuang , Toy Patrick H.
Published: September 2016

Esterification reactions between alcohols and carboxylic acids are carried out using linear polystyrene functionalized with both nucleophilic DMAP groups and tertiary amine groups as catalyst.
ChemInform Abstract: The First Example of Catalytic Synthesis of N‐Aryl‐Substituted Tetraoxazaspiroalkanes.
Authors: Makhmudiyarova Nataliya N. , Khatmullina Guzeliya M. , Rakhimov Rustem Sh. , Meshcheryakova Ekaterina S. , Ibragimov Askhat G. , Dzhemilev Usein M.
Published: September 2016

A Sm(NO3)3‐catalyzed ring transformation of pentaoxaspiroalkanes with aromatic amines provides N‐aryltetraoxazaspiroalkanes efficiently.
ChemInform Abstract: Syntheses, Structures and Optoelectronic Properties of Spiroconjugated Cyclic Ketones.
Authors: Wilbuer Jennifer , Schnakenburg Gregor , Esser Birgit
Published: September 2016

A short two‐step protocol is developed for the synthesis of spiro‐tetraketone (IV).
ChemInform Abstract: Stereoselective Monoamine Oxidase‐Catalyzed Oxidative Aza‐Friedel—Crafts Reactions of meso‐Pyrrolidines in Aqueous Buffer.
Authors: de Graaff Corien , Oppelaar Barry , Peruch Olivier , Vande Velde Christophe M. L. , Bechi Beatrice , Turner Nicholas J. , Ruijter Eelco , Orru Romano V. A.
Published: September 2016

An one‐pot chemoenzymatic oxidative aza‐Friedel—Crafts reaction for the direct α‐functionalization of pyrrolidines including both secondary as well as tertiary amines is developed.
ChemInform Abstract: An Aged Precatalyst Solution Leads to High Catalytic Activity: Oxidative Cyclization of 1,5‐Dienes Using ppm Amounts of Ruthenium.
Authors: Adrian Juliane , Roth Stefanie , Stark Christian B. W.
Published: September 2016

Tetrahydrofuran diols are diastereoselectively prepared by highly efficient oxidative cyclization from simple achiral 1,5‐dienes using an aged aqueous solution of ruthenium(III) chloride.
ChemInform Abstract: A New Method for C—H Functionalization of Aliphatic Compounds by an Unusual Photochemical Reaction of Diazoketones Without Elimination of Nitrogen.
Authors: Rodina Liudmila L. , Galkina Olesia S. , Maas Gerhard , Platz Matthew S. , Nikolaev Valerij A.
Published: September 2016

Benzophenone‐sensitized reactions of diazotetrahydrofuranones with H‐donors like tetrahydrofuran, dioxane, cyclohexane, and diethyl ether, occur without elimination of nitrogen and give rise to the formation of N‐substituted hydrazones or bis‐hydrazonoethanes, due to a formal insertion of the terminal N‐atom of the diazo group into α‐C‐H bonds of ethers and aliphatic hydrocarbons.
ChemInform Abstract: Enantioselective Rhodium‐Catalyzed Cycloisomerization of (E)‐1,6‐Enynes.
Authors: Deng Xu , Ni Shao‐Fei , Han Zheng‐Yu , Guan Yu‐Qing , Lv Hui , Dang Li , Zhang Xu‐Mu
Published: September 2016

A Rh(I)‐catalyzed asymmetric cycloisomerization of (E)‐1,6‐enynes is developed to afford various highly functionalized five‐membered cycles.
ChemInform Abstract: N‐Vinyl‐2‐(trifluoroacetylethynyl)pyrroles and E‐2‐(1‐Bromo‐2‐trifluoroacetylethenyl)pyrroles: Cross‐Coupling vs. Addition During C—H‐Functionalization of Pyrroles with Bromotrifluoroacetylacetylene in Solid Al2O3 Medium. H‐Bonding Control.
Authors: Tomilin Denis N. , Gotsko Maxim D. , Sobenina Lyubov N. , Ushakov Igor A. , Afonin Andrey V. , Soshnikov Dmitri Yu. , Trofimov Alexander B. , Koldobsky Andrey B. , Trofimov Boris A.
Published: September 2016

Depending on the substituent character at the nitrogen atom, pyrroles react acetylene (II) in two different directions.
ChemInform Abstract: Palladium—Polypyrrole Nanocomposites Pd@PPy for Direct C—H Functionalization of Pyrroles and Imidazoles with Bromoarenes.
Authors: Bizouard Pierre , Testa Christelle , Zinovyeva Veronika A. , Roger Julien , Hierso Jean‐Cyrille
Published: September 2016

The direct arylation of substituted pyrroles and imidazoles is presented.
ChemInform Abstract: Organocatalytic Enantioselective Alkylation of Pyrazol‐3‐ones with Isatin‐Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters.
Authors: Amr Fares Ibrahim , Vila Carlos , Blay Gonzalo , Munoz M. Carmen , Pedro Jose R.
Published: September 2016

The title reaction is efficiently catalyzed by a quinine‐derived thiourea, providing a variety of aminooxindole‐pyrazolone adducts containing congested vicinal tetrasubstituted stereocenters with high diastereoselectivity.
ChemInform Abstract: Efficient Ecofriendly Synthesis of Pyrazole Acryloyl Analogues by Amino Acid Catalysis.
Authors: Chaudhry Faryal , Asif Nadia , Shafqat Syed Salman , Khan Amir Azam , Munawar Munawar Ali , Khan Misbahul Ain
Published: September 2016

Glycine is successfully employed as a proper catalyst for the Knoevenagel condensation of pyrazole‐4‐carbaldehydes (I) with active methylene compounds such as (II), (IV) and (VI) to yield pyrazole acryloyl analogues efficiently.
ChemInform Abstract: Catalytic Performance of Hydrophobic Sulfonated Nanocatalysts CMK‐5‐SO3H and SBA‐15‐Ph‐PrSO3H for Ecofriendly Synthesis of 2‐Substituted Benzimidazoles in Water.
Authors: Zareyee Daryoush , Tuyehdarvary Sakineh Rostamian , Allahgholipour Leila , Hossaini Zinatossadat , Khalilzadeh Mohammad A.
Published: September 2016

The title benzimidazoles are prepared from various aldehydes and benzenediamine under green reaction conditions.
ChemInform Abstract: Quickly FeCl3‐Catalyzed Highly Chemo‐ and Stereo‐Selective [3 + 2] Dipolar Cycloaddition of Aziridines with Isothiocyanates
Authors: Gao Lingfeng , Fu Kai , Zheng Gengxiu
Published: September 2016

affording a wide range of thiazolidinylideneanilines in two up to five minutes
ChemInform Abstract: Palladium‐Catalyzed Arylations in 4‐Pyrone Systems: 2,6‐Diaryl‐3,5‐dibromo‐4‐pyrones and Kojic Acid.
Authors: Ghasemi Zarrin , Poorhossain Mejarshin Fatemeh , Fathi Zahra , Shahrisa Aziz
Published: September 2016

The reaction of commercially available kojic acid with aryl bromides (II) under catalysis of a Pd—NHC complex results in the C‐6 arylated products (III) in moderate yields, whereas the coupling of imidazole and benzimidazole with 2,6‐diaryl‐3,5‐dibromo‐4‐pyrones (IV) produces C‐3 monosubstituted products under similar conditions.
ChemInform Abstract: Trifluoroacetic Acid Catalyzed Highly Regioselective Bromocyclization of Styrene‐Type Carboxylic Acid.
Authors: Chen Tao , Yeung Ying‐Yeung
Published: September 2016

A trifluoroacetic acid catalyzed highly 6‐endo regioselective bromocyclization of styrene‐type carboxylic acid is developed to synthesize 3,4‐dihydroisocoumarine derivatives.
ChemInform Abstract: A First Example of Cobalt‐Catalyzed Remote C—H Functionalization of 8‐Aminoquinolines Operating Through a Single Electron Transfer Mechanism.
Authors: Whiteoak Christopher J. , Planas Oriol , Company Anna , Ribas Xavi
Published: September 2016

A novel Co‐catalyzed remote nitration protocol for the preparation of 5‐ and 7‐nitro‐8‐aminoquinolines using installable and removable ancillary groups is described.
ChemInform Abstract: (Pentamethylcyclopentadienyl)cobalt(III)‐Catalyzed Oxidative [4 + 2] Annulation of N—H Imines with Alkynes: Straightforward Synthesis of Multisubstituted Isoquinolines.
Authors: Zhang Shang‐Shi , Liu Xu‐Ge , Chen Shi‐Yong , Tan Dong‐Hang , Jiang Chun‐Yong , Wu Jia‐Qiang , Li Qingjiang , Wang Honggen
Published: September 2016

The title reaction shows broad substrate scope, high functional group tolerance, and generally good yields.
ChemInform Abstract: Rhodium‐Catalyzed Tandem Annulation Reactions of 7‐Azaindoles with Electron‐Deficient Olefins via Double C—H Activation.
Authors: Li Shuai‐Shuai , Lin Hui , Liu Chen‐Fei , Xia Ying‐Qi , Zhang Xiao‐Mei , Dong Lin
Published: September 2016

An tandem annulation reaction using 7‐azaindole as the directing group is described.
ChemInform Abstract: Silver(I)‐Catalyzed Tandem Sigamatropic Rearrangement/1,3‐H Shift/6π Aza‐Electrocyclization of N‐Propargylic Hydrazones: A Mild Synthetic Route to 1,6‐Dihydropyridazines.
Authors: Ding Zong‐Cang , Ju Lu‐Chuan , Yang Ying , An Xiao‐Ming , Zhou Yun‐Bing , Li Ren‐Hao , Tang Hai‐Tao , Ding Cheng‐Ke , Zhan Zhuang‐Ping
Published: September 2016

A highly efficient [3,3] sigmatropic rearrangement/1,3‐H shift/6π aza‐electrocyclization cascade reaction of N‐propargylic hydrazones leads to functionalized 1,6‐dihydropyridazines.
ChemInform Abstract: DABCO‐Based Ionic Liquids: Green and Recyclable Catalysts for the Synthesis of Barbituric and Thiobarbituric Acid Derivatives in Aqueous Media.
Authors: Seyyedi Narges , Shirini Farhad , Nikoo Langarudi Mohaddeseh Safarpoor
Published: September 2016

Arylidine barbituric and thiobarbituric acids are prepared by reaction of barbituric acid and its thio‐analogue with various aldehydes under green reaction conditions.
ChemInform Abstract: Direct Regioselective C(sp2)—H Trifluoromethylation of Pyrimidinones and Pyridinones.
Authors: Zhang Pei‐Zhi , Li Cheng‐Kun , Zhang Guo‐Yu , Zhang Ling , Jiang Yao‐Jia , Zou Jian‐Ping
Published: September 2016

Steric hindrance due to bulky groups adjacent to the position of attack by the trifluoromethyl radical decreases the yields.
ChemInform Abstract: Synthesis of Antitumor 3,4,6,7‐Tetrahydro‐2H‐pyrimido[1,6‐c]quinazolin‐2‐imine Derivatives via Reductive Dearomatization‐Initiated Intramolecular Cyclization.
Authors: Zheng Canhui , et al.
Published: September 2016

The title compounds show good inhibitory activity against specific kinases and human cancer cell lines.
ChemInform Abstract: Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones.
Authors: Hsieh Sheng‐Ying , Bode Jeffrey W.
Published: September 2016

Various silicon amines undergo photocatalytic cross‐coupling with a wide range of aromatic, heteroaromatic, and aliphatic aldehydes to give piperazine derivatives.
ChemInform Abstract: Palladium‐Catalyzed Tandem‐Cyclization of Functionalized Ynamides: An Approach to Benzosultams.
Authors: Siva Reddy Alla , Siva Kumari A. Leela , Saha Soumen , Kumara Swamy K. C.
Published: September 2016

A novel synthetic strategy for a wide range of pharmaceutically attractive benzosultams by Pd‐catalyzed nucleophilic attack on functionalized ynamides is reported.
ChemInform Abstract: Facile, Odorless, Quantitative Synthesis of 3‐Hydroxy‐3,4‐dihydro‐2H‐1,4‐thiazines.
Authors: Mari Giacomo , Favi Gianfranco , Crescentini Lucia De , Santeusanio Stefania , Attanasi Orazio A. , Mantellini Fabio
Published: September 2016

A sulfa‐Michael addition/formal [3+3] annulation cascade reaction between diazadienes and dithianediol by a one‐pot base‐promoted strategy provides a metal‐free and facile approach to thiazines in total atom economy and quantitative yields.
ChemInform Abstract: Silver‐Promoted Cinnamamidyl Radical‐Mediated Oxidative Cascade Cyclization: Highly Regioselective Synthesis of Phosphorylated Azaspiro[4.5]decenones.
Authors: Zhou Zhao‐Zhao , Zheng Lan , Yan Xiao‐Biao , Jin Dong‐Po , He Yu‐Tao , Liang Yong‐Min
Published: September 2016

An oxidative cyclization of N‐anisylsulfonylated propynamides with phosphites leads to oxoazaspiro[4.5]decenephosponates through a cascade phosphorylation/1,5‐aryl migration/desulfonylation/dearomatization sequence.
ChemInform Abstract: Remote Functionalization in Nicholas Reactions of Vinylogous γ‐Carbonyl Cations.
Authors: Mahmood Aqsa , Ngenzi Rebecca , Penner Page M. , Green James R.
Published: September 2016

Nicholas reactions of enynoate‐Co2(CO)6 complexes are demonstrated to give ε‐functionalized carbonyl compounds with high selectivity.
ChemInform Abstract: Astraeusins A—L, Lanostane Triterpenoids from the Edible Mushroom Astraeus odoratus
Authors: Isaka Masahiko , Palasarn Somporn , Srikitikulchai Prasert , Vichai Vanicha , Komwijit Somjit
Published: September 2016

examples shown
ChemInform Abstract: A Depsidone and Six Triterpenoids from the Bark of Garcinia celebica.
Authors: Bui Thai Q. , Bui An T. , Nguyen Kien T. , Nguyen Vy T. , Trinh Binh T.D. , Nguyen Lien‐Hoa D.
Published: September 2016

The new depsidone, garcinisidone H (I), and six novel triterpenoids (II‐VII) are isolated from the bark of Garcinia celebica along with twelve known compounds.
ChemInform Abstract: Doped or Not Doped: Ionic Impurities for Influencing the Phase and Growth of Semiconductor Nanocrystals
Authors: Guria Amit K. , Pradhan Narayan
Published: September 2016

Review: 140 refs.
ChemInform Abstract: Recent Trends in Nucleotide Synthesis
Authors: Roy Beatrice , Depaix Anais , Perigaud Christian , Peyrottes Suzanne
Published: September 2016

Review: 270 refs.
ChemInform Abstract: Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products
Authors: Hu Dennis X. , Withall David M. , Challis Gregory L. , Thomson Regan J.
Published: September 2016

Review: 158 refs.
ChemInform Abstract: Pillar‐Shaped Macrocyclic Hosts Pillar[n]arenes: New Key Players for Supramolecular Chemistry
Authors: Ogoshi Tomoki , Yamagishi Tada‐aki , Nakamoto Yoshiaki
Published: September 2016

Review: 291 refs.
ChemInform Abstract: Catalytic Reduction of CO2 by Renewable Organo‐Hydrides
Authors: Lim Chern‐Hooi , Holder Aaron M. , Hynes James T. , Musgrave Charles B.
Published: September 2016

Review: 42 refs.
ChemInform Abstract: Enhanced Catalytic Performance of Bimetallic Nickel‐Cobalt Loaded Low‐Content Au Catalyst Toward Ethanol Electro‐Oxidation
Authors: Yu Cheng , Yan Zhaoxiong , Zhu Lihong , Wen Juan , Wang Hongqiang , Xu Zhihua
Published: September 2016

Review: 42 refs.
ChemInform Abstract: Epoxidation of Olefins with Molecular Catalysts in Ionic Liquids
Authors: Muenchmeyer Christian J. , Graser Lilian R. , Markovits Iulius I. E. , Cokoja Mirza , Kuehn Fritz E.
Published: September 2016

Review: 98 refs.
ChemInform Abstract: Pd/Norbornene: A Winning Combination for Selective Aromatic Functionalization via C—H Bond Activation
Authors: Della Ca Nicola , Fontana Marco , Motti Elena , Catellani Marta
Published: September 2016

Review: 71 refs.
ChemInform Abstract: Chemistry of the Redox Series from Hexahydroxybenzene to Cyclohexanehexanone
Authors: Hettegger Hubert , Hosoya Takashi , Rosenau Thomas
Published: September 2016

Review: 86 refs.
ChemInform Abstract: Minor Enantiomer Recycling ‐ A Strategy to Improve Enantioselectivity
Authors: Moberg Christina
Published: September 2016

Review: 35 refs.
ChemInform Abstract: Metal‐Catalyzed Oxidation of C—X (X: S, O) in Ionic Liquids
Authors: Rosatella Andreia A. , Afonso Carlos A. M.
Published: September 2016

Review: 46 refs.
ChemInform Abstract: Functionalized Benzimidazole Scaffolds: Privileged Heterocycle for Drug Design in Therapeutic Medicine
Authors: Ajani Olayinka O. , Aderohunmu Damilola V. , Ikpo Chinwe O. , Adedapo Adebusayo E. , Olanrewaju Ifedolapo O.
Published: September 2016

Review: [270 refs.
ChemInform Abstract: Covalent EGFR Inhibitors: Binding Mechanisms, Synthetic Approaches, and Clinical Profiles
Authors: Hossam Monia , Lasheen Deena S. , Abouzid Khaled A. M.
Published: September 2016

Review: 100 refs.
ChemInform Abstract: Challenges in the Heterologous Production of Antibiotics in Streptomyces
Authors: Bekiesch Paulina , Basitta Patrick , Apel Alexander K.
Published: September 2016

Review: 62 refs.
ChemInform Abstract: Supramolecular Antibiotic Switches: A Potential Strategy for Combating Drug Resistance
Authors: Bai Haotian , Lv Fengting , Liu Libing , Wang Shu
Published: September 2016

Review: 52 refs.
ChemInform Abstract: Some of Tomorrow′s Catalysts for Processing Renewable and Non‐Renewable Feedstocks, Diminishing Anthropogenic Carbon Dioxide and Increasing the Production of Energy
Authors: Thomas John Meurig , Harris Kenneth D. M.
Published: September 2016

Review: 144 refs.
On the morphology of BaMoO4 crystals: A theoretical and experimental approach
Authors: Oliveira Marisa C. , Gracia Lourdes , Nogueira Içamira C. , Gurgel Maria Fernanda C. , Mercury Jose Manuel R. , Longo Elson , Andrés Juan
Published: September 2016

BaMoO4 crystals were obtained by a co‐precipitation method, and their structures were characterized by X‐ray diffraction and Rietveld refinement techniques. Field emission scanning electron microscopy was utilized to investigate the morphology of the as‐synthesized aggregates.‐ Through systematic first principle calculations within the density functional theory method at the B3LYP level, we investigated the structure; the surface stability of the (001), (101), (110), (100), (111), and (112) surfaces; and the morphological transformations of BaMoO4. The relative surfaces energies were further varied to predict a complete map of the available morphologies through a Wulff construction approach. This revealed that the obtained experimental and theoretical morphologies coincided when the surface energy values of the (001) surface decreased while those of the (100) and (101) facets increased simultaneously. Analysis of the surface structures showed that the electronic properties were associated with the presence of undercoordinated [BaOx] (x = 4, 5, and 6) and [MoOy] (y = 3) clusters. The presented results provide a comprehensive catalog of the morphologies most likely to be present under realistic conditions, and will serve as a starting point for future studies on the surface chemistry of BaMoO4 crystals.
Hydrogen Bonding and Stability of Hybrid Organic–Inorganic Perovskites
Authors: El‐Mellouhi Fedwa , Marzouk Asma , Bentria El Tayeb , Rashkeev Sergey N. , Kais Sabre , Alharbi Fahhad H.
Published: September 2016

In the past few years, the efficiency of solar cells based on hybrid organic–inorganic perovskites has exceeded the level needed for commercialization. However, existing perovskites solar cells (PSCs) suffer from several intrinsic instabilities, which prevent them from reaching industrial maturity, and stabilizing PSCs has become a critically important problem. Here we propose to stabilize PSCs chemically by strengthening the interactions between the organic cation and inorganic anion of the perovskite framework. In particular, we show that replacing the methylammonium cation with alternative protonated cations allows an increase in the stability of the perovskite by forming strong hydrogen bonds with the halide anions. This interaction also provides opportunities for tuning the electronic states near the bandgap. These mechanisms should have a universal character in different hybrid organic–inorganic framework materials that are widely used.
Evaluating potential trade‐offs among fuel treatment strategies in mixed‐conifer forests of the Sierra Nevada
Authors: Stevens Jens T. , Collins Brandon M. , Long Jonathan W. , North Malcolm P. , Prichard Susan J. , Tarnay Leland W. , White Angela M.
Published: September 2016

Fuel treatments in fire‐suppressed mixed‐conifer forests are designed to moderate potential wildfire behavior and effects. However, the objectives for modifying potential fire effects can vary widely, from improving fire suppression efforts and protecting infrastructure, to reintroducing low‐severity fire, to restoring and maintaining variable forest structure and wildlife habitat. In designing a fuel treatment, managers can alter the treatment's prescription, placement, and extent (collectively the “treatment strategy”) to optimally meet one objective. However, the potential for trade‐offs among different objectives is rarely tested systematically in fire‐prone landscapes. To evaluate trade‐offs in mechanical fuel treatment objectives related to fire severity, smoke production, forest heterogeneity, and avian wildlife habitat, we used a cross‐platform modeling approach based on spatially explicit modifications of forest structure data for a 7820‐ha landscape in the Lake Tahoe Basin, California. We examine whether (1) a more uniform treatment strategy aimed at fire hazard reduction (FHR) had negative effects on wildlife diversity, (2) a strategy focused on protecting the wildland–urban interface (WUI) left other portions of the landscape vulnerable to high‐severity fire, and (3) increasing the extent of fuel treatments across the landscape led to greater reductions in fire severity and smoke emissions. When approximately 13% of the landscape was treated, the proportion of the landscape vulnerable to high‐severity fire decreased by 13–44%, with the more uniform FHR strategy leading to greater reductions. Slight increases in predicted avian species richness that followed all treatment strategies were not closely linked to increases in canopy variability. TheWUIprotection strategy led to considerable reductions in fire severity at the landscape scale. Increasing the extent of treatments to 30% of the landscape did little to further reduce the area vulnerable to high‐severity fire, with additional reductions of 4–7% depending on the prescription. However, increasing the extent of treatments reduced the extent of harmful downwind smoke impacts, primarily by reducing rate of fire spread. Treatment strategies will depend on specific management objectives, but we illustrate that trade‐offs are not necessarily inherent in general outcomes of fuel treatments.
Prediction of output energies for broiler production using linear regression, ANN (MLP, RBF), and ANFIS models
Authors: Amid Sama , Mesri Gundoshmian Tarahom
Published: September 2016

In this study, artificial neural networks and fuzzy inference systems and the combination of these two are employed to develop predictive models to input and output parameters for broiler production. The data was randomly collected from 70 broiler farms in northwestern Iran. The energy used in broiler production was determined to be fuel, feed, and electricity; these were selected as input parameters for the models. The corresponding output energies (broilers and manure) were used as output variables. Linear regression, the multi‐layer perceptron and the radial basis function as the methods of artificial neural networks, and the adaptive neuro‐fuzzy inference system were simulated and compared for prediction of broiler and manure energy. A comparison of the results showed that radial basis function recorded higher coefficient of determination (0.996 and 0.995 for broiler and manure) and lower root mean square error (0.016 and 0.02 for broiler and manure) values to make it the best predictor of outputs. This was followed in order by the adaptive neuro‐fuzzy inference system, linear regression, and multi‐layer perceptron models. © 2016 American Institute of Chemical Engineers Environ Prog, 36: 577–585, 2017
Integrated Modelling System with Uncertainty Analysis for Reservoir Water Quality Management in a Reclamation River Basin
Authors: Ham Jonghwa , Hong Yoon‐Seok Timothy
Published: September 2016

A developed integrated modelling system with uncertainty analysis (Monte Carlo simulation and generalized likelihood uncertainty estimation) was used to evaluate the effect of uncertainty sources on long‐term water quality and develop river basin management measures to meet the specified water quality criteria based on the predicted probability of occurrence in the reclamation river basin. The results of the deterministic integrated modelling system without uncertainty analysis showed that the Hwaong Reservoir water quality for total phosphorus (T‐P) (0.094 mg l−1) in 2022 would meet the reservoir water quality standard (0.1 mg l−1). However, the water quality prediction for the Hwaong Reservoir in 2022 using the integrated modelling system with uncertainty analysis showed that only 28% would meet the T‐P water quality standard, indicating that to meet the water quality standard with a 90% level of confidence, further river basin management measures should be applied in addition to the construction of planned wastewater treatment plants and treatment wetlands. The developed integrated modelling system with uncertainty analysis was demonstrated to be advantageous because it can allow modellers to make useful decisions about whether a river basin management plan can meet specified water quality criteria based on the probability of occurrence. Copyright © 2016 John Wiley & Sons, Ltd.
Features selection, data mining and finacial risk classification: a comparative study
Authors: Lahmiri Salim
Published: September 2016

The aim of this paper is to compare several predictive models that combine features selection techniques with data mining classifiers in the context of credit risk assessment in terms of accuracy, sensitivity and specificity statistics. The t‐statistic, Battacharrayia statistic, the area between the receiver operating characteristic, Wilcoxon statistic, relative entropy, and genetic algorithms were used for the features selection task. The selected features are used to train the support vector machine (SVM) classifier, backpropagation neural network, radial basis function neural network, linear discriminant analysis and naive Bayes classifier. Results from three datasets using a 10‐fold cross‐validation technique showed that the SVM provides the best accuracy under all features selections techniques adopted in the study for all three datasets. Therefore, the SVM is an attractive classifier to be used in real applications for bankruptcy prediction in corporate finance and financial risk management in financial institutions. In addition, we found that our best results are superior to earlier studies on the same datasets.
Does the Harvesting Technique Affect the Properties of Adipose‐Derived Stem Cells?—The Comparative Biological Characterization
Authors: Bajek Anna , Gurtowska Natalia , Olkowska Joanna , Maj Małgorzata , Kaźmierski Łukasz , Bodnar Magdalena , Marszałek Andrzej , Dębski Robert , Drewa Tomasz
Published: September 2016

The objective of this study was to evaluate complex biological properties of human stem cells isolated from adipose tissue (ASCs) harvested utilizing different methods: surgical resection (R), power‐assisted liposuction (PAL), and laser‐assisted liposuction (LAL). ASCs were isolated from healthy donors, due to surgical resection, power‐, and laser‐assisted liposuction. Isolated cells were characterized by their clonogenicity, proliferation rate, doubling time, multilineage differentiation, and senescence potential. The average number of ASCs from 1g/1 ml of solid adipose tissue/lipoaspirate was 2.9 × 105 ± 2.4 × 105, 1.1 × 105 ± 0.8 × 105, and 1.2 × 105 ± 0.7 × 105, respectively, for ASCsR, ASCsPAL, and ASCsLAL. However, number of colonies formed by ASCsR and ASCsPAL was significantly higher compared to the average number of colonies formed by ASCsLAL. Also, in comparison to other analyzed cell groups, ASCsPAL obtained the highest proliferative activity. All analyzed cells were characterized by stable expression of CD90 and CD44 markers during prolonged culture. Expression of CD34 and CD45 markers was decreasing in subsequent passages. Presented study shows that different ASCs collection method affects some basic characteristics of these cells, such as number of isolated cells, clonogeneity, or doubling time. J. Cell. Biochem. 118: 1097–1107, 2017. © 2016 Wiley Periodicals, Inc.
IL‐15 and RANKL Play a Synergistically Important Role in Osteoclastogenesis
Authors: Okabe Iichiro , Kikuchi Takeshi , Mogi Makio , Takeda Hiroaki , Aino Makoto , Kamiya Yosuke , Fujimura Takeki , Goto Hisashi , Okada Kosuke , Hasegawa Yoshiaki , Noguchi Toshihide , Mitani Akio
Published: September 2016

Interleukin‐15 (IL‐15), a cytokine secreted by several cell types, has important physiological roles in the activity, proliferation, and viability of immune cells. It has both chemoattractant and proinflammatory properties, and may promote bone destruction. A previous study has shown that IL‐15 alone exerts no effect on osteoclastogenesis. Therefore, the current study addressed the synergistic effect of IL‐15 on osteoclast formation using RAW264.7 (RAW) cells by co‐stimulation with receptor activator of nuclear factor (NF)‐κB ligand (RANKL) that has a major role in osteoclastogenesis involving the pathogenesis of rheumatoid arthritis and periodontal disease. Co‐stimulation of RAW cells by IL‐15 and RANKL significantly increased the gene expression of osteoclast differentiation and osteoclastogenesis markers compared with stimulation by RANKL or IL‐15 independently as evaluated by tartrate‐resistant acid phosphate‐positive cell numbers, the fusion index, a pit formation assay with Alizarin red staining (calcification estimation), and quantitative polymerase chain reaction. Phosphorylation of extracellular signal‐regulated kinase (ERK), c‐jun N‐terminal kinase, p38 mitogen‐activated protein kinase, and NF‐κB was significantly increased by RANKL and IL‐15 (P < 0.05) compared with RANKL alone. In addition, these differentiation activities induced by RANKL and IL‐15 were comparatively suppressed by inhibition of ERK, suggesting that this synergistic effect on osteoclastogenesis is mainly mediated by ERK. Taken together, our results demonstrate that IL‐15 and RANKL induce osteoclastogenesis synergistically, and IL‐15 might play a novel and major role in destructive inflammatory bone diseases. J. Cell. Biochem. 118: 739–747, 2017. © 2016 Wiley Periodicals, Inc.
mTORC1 Signaling Promotes Limb Bud Cell Growth and Chondrogenesis
Authors: Jiang Ming , Fu Xuejie , Yang Huilin , Long Fanxin , Chen Jianquan
Published: September 2016

mTORC1 signaling has been shown to promote limb skeletal growth through stimulation of protein synthesis in chondrocytes. However, potential roles of mTORC1 in prechondrogenic mesenchyme have not been explored. In this study, we first deleted Raptor, a unique and essential component of mTORC1, in prechondrogenic limb mesenchymal cells. Deletion of Raptor reduced the size of limb bud cells, resulting in overall diminution of the limb bud without affecting skeletal patterning. We then examined the potential role of mTORC1 in chondrogenic differentiation in vitro. Both pharmacological and genetic disruption of mTORC1 significantly suppressed the number and size of cartilage nodules in micromass cultures of limb bud mesenchymal cells. Similarly, inhibition of mTORC1 signaling in chondrogenic ATDC5 cells greatly impaired cartilage nodule formation, and decreased the expression of the master transcriptional factor Sox9, along with the cartilage matrix genes Acan and Col2a1. Thus, we have identified an important role for mTORC1 signaling in promoting limb mesenchymal cell growth and chondrogenesis during embryonic development. J. Cell. Biochem. 118: 748–753, 2017. © 2016 Wiley Periodicals, Inc.
Allergen‐Specific IgE Measurement: Intermethod Comparison of Two Assay Systems in Diagnosing Clinical Allergy
Authors: Bulat Lokas Sandra , Plavec Davor , Rikić Pišković Josipa , Živković Jelena , Nogalo Boro , Turkalj Mirjana
Published: September 2016

Background

Our aim was to examine the performance of IMMULITE 2000 assay for specific IgE (sIgE) by comparing it with ImmunoCAP technology in light of a clinical background.

Methods

Measurements of sIgE were done in a selected patient group (N = 569; varied sample size for each allergen) and in a random sample group (N = 100; 8 allergens). sIgE results were correlated with skin‐prick test results (selected patients) and medical history (nonselected patients).

Results

We have detected fair to excellent correlation and agreement between the results of both assays, despite their methodological differences, both in selected and nonselected patient group (ρc = 0.431–0.976; ρc = 0.390–0.972, respectively). Associations of sIgE levels with skin‐prick test (SPT) levels and medical history have shown significant correlation for both assays for majority of tested allergens, where applicable (D. pteronyssinus, cat dander, egg white, milk, peanut, orchard grass, Alternaria tenuis, and common ragweed in selected patients; birch, cat dander, common ragweed, D. pteronyssinus, and orchard grass in nonselected; P < 0.05 for all).

Conclusions

Laboratory testing for sIgE can be successfully accomplished by IMMULITE 2000 immunoanalyzer at a diagnostic accuracy relative to SPT, comparable to the results acquired by CAP technology but not fully comparable on the level of an individual patient.
Experimental study for the establishment of an evaluation criterion for the image sticking effect in OLED TV panels
Authors: Jang Youn‐hee , Kim Ki‐tae , Lee Hye‐mi , Lee Jae‐eun , Kim Ji‐hoon , Oh Chang‐seok , Lee Duek‐jung , Jang Joong‐soon
Published: September 2016

The individual elements of organic light‐emitting diode (OLED) displays degrade at different rates, because each element emits light independently; the resulting luminance differences between individual elements cause image sticking—a phenomenon where a displayed text or pattern remains on the screen even after changing the image contents—and are therefore an important issue in OLED displays. However, the introduction of OLED technology into large TV displays is still recent, and no criterion for image sticking evaluation has yet been established. The keystone of a criterion for image sticking evaluation is the definition of the difference level between the luminance of individual elements at which the viewer feels that image sticking is present. Therefore, in this study, an image sticking perception experiment is carried out in accordance with statistically sound procedures for experimental design, using a comprehensive set of human subjects to evaluate the presence of image sticking in moving images. The obtained results are analyzed, and two criteria for image sticking evaluation are proposed.
Rate Coefficient for the Gas‐Phase OH + CHF=CF2 Reaction between 212 and 375 K
Authors: Baasandorj Munkhbayar , Burkholder James B.
Published: September 2016

Rate coefficients, k(T), for the OH + CHF=CF2 (trifluoroethylene, HFO‐1123) gas‐phase reaction were measured under pseudo–first‐order conditions using pulsed laser photolysis to produce OH radicals and pulsed laser induced fluorescence to measure the OH radical temporal profile. Rate coefficients were measured over the temperature range 212–375 K at total pressures between 20 and 500 Torr (He, N2 bath gas). The rate coefficient was found to be independent of pressure over this range of pressure with a temperature dependence that is described by the Arrhenius expression (3.04 ± 0.30) × 10–12 exp[(312 ± 25)/T] cm3 molecule–1 s–1 with k(296 K) measured to be (8.77 ± 0.80) × 10–12 cm3 molecule–1 s–1 (quoted uncertainties are 2σ and include estimated systematic errors). Rate coefficients for the reaction of CHF=CF2 with 18OH and OD were also measured as part of this study at 296 and 373 K and a total pressure of ∼25 Torr (He). The isotope measurements were used to evaluate the observed OH radical regeneration. CHF=CF2 is a very short‐lived substance with an atmospheric lifetime of ∼1 day with respect to OH reactive loss, whereas the actual lifetime of CHF=CF2 will depend on the time and location of its emission. The global warming potential for CHF=CF2 on the 100‐year time horizon (GWP100) was estimated using the present results and a lifetime correction factor to be 3.9 × 10−3.
In vivo tumor identification of colorectal liver metastases with diffuse reflectance and fluorescence spectroscopy
Authors: Tanis Erik , Evers Danny J. , Spliethoff Jarich W. , Pully Vishnu V. , Kuhlmann Koert , van Coevorden Frits , Hendriks Benno H.W. , Sanders Joyce , Prevoo Warner , Ruers Theo J.M.
Published: September 2016

Background and Objective

Over the last decade, an increasing effort has been put towards the implementation of optical guidance techniques to aid surgeons during cancer surgery. Diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS) are two of these new techniques. The objective of this study is to investigate whether in vivo optical spectroscopy is able to accurately discriminate colorectal liver metastases (CRLM) from normal liver tissue in vivo.

Materials and Methods

DRS and FS were incorporated at the tip of a needle and were used for in vivo tissue differentiation during resection of CRLM. Measurements were taken in and around the tumor lesions and measurement sites were marked and correlated to histology (i.e., normal liver tissue or tumor tissue). Patients with and without neoadjuvant systemic chemotherapy were included into the study.

Results

Four hundred and eighty‐four measurements were taken in and near 19 liver lesions prior to resection. Overall sensitivity and specificity for DRS was 95% and 92%, respectively. Bile was the most discriminative parameter. The addition of FS did not improve the overall accuracy. Sensitivity and specificity was not hampered by neo‐adjuvant chemotherapy; sensitivity and specificity after neo‐adjuvant chemotherapy were 92% and 100%, respectively.

Conclusion

We have successfully integrated spectroscopy technology into a disposable 15 Gauge optical needle and we have shown that DRS and FS can accurately discriminate CRLM from normal liver tissue in the in vivo setting regardless of whether the patient was pre‐treated with systemic therapy. This technique makes in vivo guidance accessible for common surgical practice. Lasers Surg. Med. 48:820–827, 2016. © 2016 Wiley Periodicals, Inc.
Reinforcing Lessons for Business from the Marketing Revolution in U.S. Presidential Politics: A Strategic Triad
Authors: Newman Bruce I.
Published: September 2016

The role of marketing in presidential politics in the United States has introduced lessons for marketing executives on how to more effectively build up brand loyalty and fend off competition. The same technological breakthroughs in marketing that have powered corporate America were used by the Obama presidential campaigns in both 2008 and 2012 to microtarget potential donors and voters, carry out massive fund‐raising campaigns, and energize a base of citizens through newly minted movements at a level of sophistication not witnessed previously in other sectors. The same techniques continued to be used in the 2016 presidential campaign, and the paradigm shift in marketing put forward in this article is represented with the introduction of a Strategic Triad that integrates the use of Big Data, microtargeting, and social media by organizations in the political, for‐profit, and nonprofit sectors.