bluuebunny/crossref_metadata_2025 huggingface dataset:
Zoledronate combined metal-organic frameworks for bone-targeting and drugs deliveries
Authors: Pan Yixiao , Wang Jiahao , Jiang Zichao , Guo Qi , Zhang Zhen , Li Jingyi , Hu Yihe , Wang Long
Published: July 2022

Medicine treatments for bone-related diseases such as osteoporosis, bone metastasis, osteomyelitis, and osteolysis are often limited by insufficient drug concentration at the lesion sites owing to the low perfusion of bone tissue. A carrier that can deliver multiple bone destruction site-targeting drugs is required to address this limitation. Here, we reported a novel bone-targeting nano-drug delivery platform formed by the integration of zoledronate (ZOL) and zeolitic imidazolate framework-8 (ZIF-8) nanoparticles. The ZOL mixed zeolitic imidazolate framework (ZZF) nanoparticles were synthesized in water at room temperature (25 °C), where many biomacromolecules could maintain their activity. This allowed the ZZF nanoparticles to adapt the encapsulation ability and pH response release property from ZIF-8 and the excellent bone targeting performance of ZOL simultaneously. Considering the ease of preparation and biomacromolecule-friendly drug delivery of this nano platform, it may be useful in treating bone-related diseases.
Bio-inspired contour extraction via EM-driven deformable and rotatable directivity-probing mask
Authors: Wang Jung-Hua , Huang Ren-Jie , Wang Ting-Yuan
Published: July 2022

This paper presents a novel bio-inspired edge-oriented approach to perceptual contour extraction. Our method does not rely on segmentation and can unsupervised learn to identify edge points that are readily grouped, without invoking any connecting mechanism, into object boundaries as perceived by human. This goal is achieved by using a dynamic mask to statistically assess the inter-edge relations and probe the principal direction that acts as an edge-grouping cue. The novelty of this work is that the mask, centered at a target pixel and driven by EM algorithm, can iteratively deform and rotate until it covers pixels that best fit the Bayesian likelihood of the binary class w.r.t a target pixel. By creating an effect of enlarging receptive field, contiguous edges of the same object can be identified while suppressing noise and textures, the resulting contour is in good agreement with gestalt laws of continuity, similarity and proximity. All theoretical derivations and parameters updates are conducted under the framework of EM-based Bayesian inference. Issues of stability and parameter uncertainty are addressed. Both qualitative and quantitative comparison with existing approaches proves the superiority of the proposed method in terms of tracking curved contours, noises/texture resilience, and detection of low-contrast contours.
Automatic parameter selection for electron ptychography via Bayesian optimization
Authors: Cao Michael C. , Chen Zhen , Jiang Yi , Han Yimo
Published: July 2022

Electron ptychography provides new opportunities to resolve atomic structures with deep sub-angstrom spatial resolution and to study electron-beam sensitive materials with high dose efficiency. In practice, obtaining accurate ptychography images requires simultaneously optimizing multiple parameters that are often selected based on trial-and-error, resulting in low-throughput experiments and preventing wider adoption. Here, we develop an automatic parameter selection framework to circumvent this problem using Bayesian optimization with Gaussian processes. With minimal prior knowledge, the workflow efficiently produces ptychographic reconstructions that are superior to those processed by experienced experts. The method also facilitates better experimental designs by exploring optimized experimental parameters from simulated data.
Neglected prognostic importance of ileal resection in patients with peritoneal metastasis
Authors: Bisgin Tayfun , Sokmen Selman , Manoglu Berke , Ozkardesler Sevda , Sarioglu Sulen , Ellidokuz Hulya
Published: July 2022

We aimed to determine the prognostic role of ileal resection on postoperative complications and the final oncological results of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) treatment in patients with peritoneal metastasis (PM). Patients with PM who underwent CRS and HIPEC between 2007 and 2020 were analyzed retrospectively. Ileal resection was defined as the resection of the ileum at 100 cm or below. Patients were divided into ileal-resection and non-ileal resection groups. Besides clinico-pathological variables, peritoneal cancer index (PCI), completeness of cytoreduction (CC-0-1-2), (neo)adjuvant chemotherapy, operative time, need for surgical intensive care unit, and usage of blood products were all evaluated. The data of 664 patients was analyzed. Ileal resection was performed in 346(52.1%) patients. The median follow-up period was 27 months. The ileal resection group had significantly lower 3-and 5-year survival rates (55% and 43% vs. 69% and 52, p = .005, respectively). High PCI score (p < .001), more CC-1-2 cytoreductions (p < .001), more anastomoses (p < .001), prolonged operative time (p < .001), more ostomy creation (p = .001), increased morbidity (p < .001), and more infectious complications (p < .001) were all significantly associated with ileal resection. The loss of ileal function has a potential prognostic role in increased post-operative complications and worsened overall survival in patients with PMs.
Large-scale changes in marine and terrestrial environments drive the population dynamics of long-tailed ducks breeding in Siberia
Authors: Rintala J. , Hario M. , Laursen K. , Møller A. P.
Published: July 2022

Migratory animals experience very different environmental conditions at different times of the year,i.e., at the breeding grounds, during migration, and in winter. The long-tailed duckClangula hyemalisbreeds in the Arctic regions of the northern hemisphere and migrates to temperate climate zones, where it winters in marine environments. The breeding success of the long-tailed duck is affected by the abundances of predators and their main prey species, lemmingsLemmus sibiricusandDicrostonyx torquatus, whose population fluctuation is subject to climate change. In the winter quarters, long-tailed ducks mainly eat the blue musselMytilus edulis. We examined how North-west Siberian lemming dynamics, assumed as a proxy for predation pressure, affect long-tailed duck breeding success and how nutrient availability in the Baltic Sea influences long-tailed duck population size via mussel biomass and quality. Evidence suggests that the long-tailed duck population dynamics was predator-driven on the breeding grounds and resource-driven on the wintering grounds. Nutrients from fertilizer runoff from farmland stimulate mussel stocks and quality, supporting high long-tailed duck population sizes. The applied hierarchical analysis combining several trophic levels can be used for evaluating large-scale environmental factors that affect the population dynamics and abundance of migrants from one environment to another.
Treatment resistance of rheumatoid arthritis relates to infection of periodontal pathogenic bacteria: a case–control cross-sectional study
Authors: Takeuchi-Hatanaka Kazu , Koyama Yoshinobu , Okamoto Kentaro , Sakaida Kyosuke , Yamamoto Tadashi , Takashiba Shogo
Published: July 2022

Recent studies have shown that periodontitis is associated with rheumatoid arthritis (RA) and periodontal bacteria, such as Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) are involved in the pathogenesis of RA via citrullinated proteins. Smoking has also been shown to be involved in the pathogenesis of RA; however, the extent of this involvement is still poorly understood. In addition, RA and polymyalgia rheumatica (PMR) are sometimes difficult to differentiate; however, the relationship between PMR and the factors from smoking and periodontal bacteria is unclear. The aim of this study was to clarify the relationship between periodontal pathogenic bacterial infections and smoking in patients with RA or PMR. This case–control study included 142 patients with untreated RA or PMR. This study evaluated the serum antibody titers against periodontal pathogenic bacterial antigens and an anti-citrullinated peptide antibody (ACPA). In patients with RA, the relationship between antibody titers and disease activity of RA and response after 3 months of treatment was also investigated. Additionally, the effects of smoking were evaluated. Although there was no significant difference in serum antibody titer against periodontal pathogenic bacteria between the ACPA-positive RA group and the ACPA-negative PMR group, we found an association between the elevated antibody titer against Pg and the degree of ACPA value, especially between negative group and high-value positive group (≥ 100 U/mL). The antibody titers against Aa and Pg did not differ depending on disease activity score 28 (DAS28) at baseline; however, patients with high antibody titers had poor RA therapeutic response as judged by DAS28 after 3 months. We could not find any association between smoking and any of these parameters. Periodontal pathogenic bacteria, especially Pg, are associated with elevated ACPA levels. Our findings suggest that Pg and Aa infections interfere with the therapeutic response of RA.
Allogeneic MHC-matched T-cell receptor α/β-depleted bone marrow transplants in SHIV-infected, ART-suppressed Mauritian cynomolgus macaques
Authors: Weinfurter Jason T. , D’Souza Saritha S. , Matschke Lea M. , Bennett Sarah , Kelnhofer-Millevolte Laurel E. , Suknuntha Kran , Kumar Akhilesh , Coonen Jennifer , Capitini Christian M. , Hematti Peiman , Golos Thaddeus G. , Slukvin Igor I. , Reynolds Matthew R.
Published: July 2022

Allogeneic hematopoietic stem cell transplants (allo-HSCTs) dramatically reduce HIV reservoirs in antiretroviral therapy (ART) suppressed individuals. However, the mechanism(s) responsible for these post-transplant viral reservoir declines are not fully understood. Therefore, we modeled allo-HSCT in ART-suppressed simian-human immunodeficiency virus (SHIV)-infected Mauritian cynomolgus macaques (MCMs) to illuminate factors contributing to transplant-induced viral reservoir decay. Thus, we infected four MCMs with CCR5-tropic SHIV162P3 and started them on ART 6–16 weeks post-infection (p.i.), maintaining continuous ART during myeloablative conditioning. To prevent graft-versus-host disease (GvHD), we transplanted allogeneic MHC-matched α/β T cell-depleted bone marrow cells and prophylactically treated the MCMs with cyclophosphamide and tacrolimus. The transplants produced ~ 85% whole blood donor chimerism without causing high-grade GvHD. Consequently, three MCMs had undetectable SHIV DNA in their blood post-transplant. However, SHIV-harboring cells persisted in various tissues, with detectable viral DNA in lymph nodes and tissues between 38 and 62 days post-transplant. Further, removing one MCM from ART at 63 days post-transplant resulted in SHIV rapidly rebounding within 7 days of treatment withdrawal. In conclusion, transplanting SHIV-infected MCMs with allogeneic MHC-matched α/β T cell-depleted bone marrow cells prevented high-grade GvHD and decreased SHIV-harboring cells in the blood post-transplant but did not eliminate viral reservoirs in tissues.
Hypertension and diabetes including their earlier stage are associated with increased risk of sudden cardiac arrest
Authors: Kim Yun Gi , Roh Seung Young , Han Kyung-Do , Jeong Joo Hee , Choi Yun Young , Min Kyongjin , Shim Jaemin , Choi Jong-Il , Kim Young-Hoon
Published: July 2022

Sudden cardiac arrest (SCA) is a medical disaster for both the victim and the society. Despite intrinsic limitations in the management of SCA, primary prevention has been overlooked and risk factors for SCA are not fully understood. We aimed to evaluate whether hypertension and diabetes mellitus (DM), including pre-hypertension and impaired fasting glucose (IFG), are associated with increased risk of SCA. We performed a nationwide population-based analysis using the Korean National Health Insurance Service. People who underwent a national health check-up in 2009 were enrolled. The risk of SCA was evaluated in people with hypertension and DM with a clinical follow-up through December 2018. A total of 4,056,423 people with 33,345,378 person-years of follow-up and 16,352 SCA events were examined. People with hypertension had 65.4% increased risk of SCA (adjusted hazard ratio [HR] = 1.654 [1.572–1.739]; p < 0.001). Pre-hypertension was also associated with 21.3% increased risk of SCA (adjusted HR = 1.213 [1.158–1.272]; p < 0.001). People who had IFG and DM showed 7.5% (adjusted HR = 1.075 [1.035–1.117]; p < 0.001) and 80.1% (adjusted HR = 1.801 [1.731–1.875]; p < 0.001) increased risk of SCA, respectively. People with DM who took anti-diabetic medication showed significantly lower risk of SCA compared with uncontrolled DM patients (fasting glucose ≥ 200 mg/dL) (adjusted HR = 0.625 [0.533–0.733]; p < 0.001). Coexistence of hypertension and DM was associated with an even higher risk of SCA (adjusted HR = 3.078 [2.877–3.293]; p < 0.001). In conclusion, the risk of SCA is significantly higher in people with hypertension and DM, including pre-hypertension and IFG. Adequate control of blood pressure and serum glucose can have a profound impact for the primary prevention of SCA in the general population.
Examining the COVID-19 case growth rate due to visitor vs. local mobility in the United States using machine learning
Authors: Katragadda Satya , Bhupatiraju Ravi Teja , Raghavan Vijay , Ashkar Ziad , Gottumukkala Raju
Published: July 2022

Travel patterns and mobility affect the spread of infectious diseases like COVID-19. However, we do not know to what extent local vs. visitor mobility affects the growth in the number of cases. This study evaluates the impact of state-level local vs. visitor mobility in understanding the growth with respect to the number of cases for COVID spread in the United States between March 1, 2020, and December 31, 2020. Two metrics, namely local and visitor transmission risk, were extracted from mobility data to capture the transmission potential of COVID-19 through mobility. A combination of the three factors: the current number of cases, local transmission risk, and the visitor transmission risk, are used to model the future number of cases using various machine learning models. The factors that contribute to better forecast performance are the ones that impact the number of cases. The statistical significance of the forecasts is also evaluated using the Diebold–Mariano test. Finally, the performance of models is compared for three waves across all 50 states. The results show that visitor mobility significantly impacts the case growth by improving the prediction accuracy by 33.78%. We also observe that the impact of visitor mobility is more pronounced during the first peak, i.e., March–June 2020.
Analysis of mutations in DNA damage repair pathway gene in Chinese patients with hepatocellular carcinoma
Authors: Li Jiarong , Li Nianfeng , Azhar Muhammad Salman , Liu Ling , Wang Liheng , Zhang Qi , Sheng Langqing , Wang Jianhua , Feng Sijia , Qiu Qixuan , Xiao Yao
Published: July 2022

The incidence of hepatocellular carcinoma (HCC) has increased in these years. DNA damage repair (DDR) pathway is required in response to DNA damage Gene mutations in DDR pathway play an important role in different stages of tumorigenesis and development. Based on the importance of DDR pathway in precision therapy of multiple cancers, we analyzed DDR gene mutations in Chinese patients with HCC. The results showed that (tumor mutation burden) TMB was significantly higher in HCC patients who carried somatic mutations in DDR than in non-carriers, and TMB in patients with DS, MMR mutations and DDR genes mutations such as RAD50, MLH1, MSH2, CHEK2 was significantly higher than that in wild-type patients. Based on the results of next-generation sequencing (NGS) testing, we are trying to provide clues for targeted therapy and provide feasible basis for PD-1/PD-L1 immune checkpoint inhibitor therapy.
Unencapsulated and washable two-dimensional material electronic-textile for NO2 sensing in ambient air
Authors: Oluwasanya Pelumi W. , Carey Tian , Samad Yarjan Abdul , Occhipinti Luigi G.
Published: July 2022

Materials adopted in electronic gas sensors, such as chemiresistive-based NO2sensors, for integration in clothing fail to survive standard wash cycles due to the combined effect of aggressive chemicals in washing liquids and mechanical abrasion. Device failure can be mitigated by using encapsulation materials, which, however, reduces the sensor performance in terms of sensitivity, selectivity, and therefore utility. A highly sensitive NO2electronic textile (e-textile) sensor was fabricated on Nylon fabric, which is resistant to standard washing cycles, by coating Graphene Oxide (GO), and GO/Molybdenum disulfide (GO/MoS2) and carrying out in situ reduction of the GO to Reduced Graphene Oxide (RGO). The GO/MoS2e-textile was selective to NO2and showed sensitivity to 20 ppb NO2in dry air (0.05%/ppb) and 100 ppb NO2in humid air (60% RH) with a limit of detection (LOD) of ~ 7.3 ppb. The selectivity and low LOD is achieved with the sensor operating at ambient temperatures (~ 20 °C). The sensor maintained its functionality after undergoing 100 cycles of standardised washing with no encapsulation. The relationship between temperature, humidity and sensor response was investigated. The e-textile sensor was embedded with a microcontroller system, enabling wireless transmission of the measurement data to a mobile phone. These results show the potential for integrating air quality sensors on washable clothing for high spatial resolution (< 25 cm2)—on-body personal exposure monitoring.
Xanthine oxidoreductase activity is correlated with hepatic steatosis
Authors: Yagi Chisako , Kusunoki Yoshiki , Tsunoda Taku , Murase Takayo , Nakamura Takashi , Osugi Keiko , Ohigashi Mana , Morimoto Akiko , Miyoshi Akio , Kakutani-Hatayama Miki , Kosaka-Hamamoto Kae , Kadoya Manabu , Konishi Kosuke , Shoji Takuhito , Koyama Hidenori
Published: July 2022

The enzyme xanthine oxidoreductase (XOR) catalyzes the synthesis of uric acid (UA) from hypoxanthine and xanthine, which are products of purine metabolism starting from ribose-5-phosphate. Several studies suggested a relationship between hyperuricemia and hepatic steatosis; however, few previous studies have directly examined the relationship between XOR activity and hepatic steatosis. A total of 223 subjects with one or more cardiovascular risk factors were enrolled. The liver-to-spleen (L/S) ratio on computed tomography and the hepatic steatosis index (HSI) were used to assess hepatic steatosis. We used a newly developed highly sensitive assay based on [13C2,15N2] xanthine and liquid chromatography/triple quadrupole mass spectrometry to measure plasma XOR activity. Subjects with the L/S ratio of < 1.1 and the HSI of < 36 had increased XOR activity and serum UA levels. Independent of insulin resistance and serum UA levels, multivariate logistic regression analysis revealed that plasma XOR activity was associated with the risk of hepatic steatosis as assessed by the L/S ratio and HSI. According to the findings of this study, plasma XOR activity is associated with hepatic steatosis independent of insulin resistance and serum UA levels.
A retrospective observational study of serum uric acid and in-hospital mortality in acute type A aortic dissection
Authors: Yang Guifang , Chai Xiangping , Ding Ning , Yang Donghua , Ding Qiong
Published: July 2022

There is currently insufficient evidence of correlation between on-admission serum uric acid and in-hospital mortality of patients with acute type A aortic dissection. Thus, this study analysed the relation between serum uric acid and in-hospital deaths in patients with acute type A aortic dissection. A total of 1048 patients with acute type A aortic dissection participated in this study between January 2010 and December 2018. The independent variable was on-admission serum uric acid, whilst the dependent variable was in-hospital deaths. The covariates of the study included patient age, gender, body mass index, smoking status, hypertension, diabetes, Marfan syndrome, bicuspid aortic valve, chronic renal insufficiency, stroke, atherosclerosis, time to presentation, systolic blood pressure, diastolic blood pressure, aortic diameter, aortic regurgitation, abdominal vessel involvement, arch vessel involvement, ejection fraction value, laboratory parameters, symptom, coronary malperfusion, mesenteric malperfusion, cerebral malperfusion, hypotension/shock, cardiac tamponade and operation status. The mean age of the sample was 50.17 ± 11.47 years, with approximately 24.24% of the participants being female. After analysis, it was found that the admission serum uric acid of patients with acute type A aortic dissection was positively correlated with in-hospital death (OR = 1.04, 95% CI 1.02–1.06). Subsequently, a non-linear relationship was determined between admission serum uric acid (point 260 µmol/L) and in-hospital mortality for patients with acute type A aortic dissection. The effect sizes and confidence intervals of the right (serum uric acid > 260 µmol/L) and left (serum uric acid ≤ 260 µmol/L) aspects of the inflection point were 1.04 (1.02–1.05) and 1.00 (0.99–1.02), respectively. Furthermore, subgroup analysis indicated a stable relationship between serum uric acid and in-hospital mortality, whilst an insignificant difference was found for the interactions between different subgroups. Overall, a non-linear correlation was determined between admission serum uric acid and in-hospital mortality of patients with acute type A aortic dissection. When serum uric acid > 260 µmol/L, it showed a positive correlation with in-hospital mortality.
Comparison of three imaging and navigation systems regarding accuracy of pedicle screw placement in a sawbone model
Authors: Beisemann Nils , Gierse Jula , Mandelka Eric , Hassel Frank , Grützner Paul A. , Franke Jochen , Vetter Sven Y.
Published: July 2022

3D-navigated pedicle screw placement is increasingly performed as the accuracy has been shown to be considerably higher compared to fluoroscopy-guidance. While different imaging and navigation devices can be used, there are few studies comparing these under similar conditions. Thus, the objective of this study was to compare the accuracy of two combinations most used in the literature for spinal navigation and a recently approved combination of imaging device and navigation system. With each combination of imaging system and navigation interface, 160 navigated screws were placed percutaneously in spine levels T11-S1 in ten artificial spine models. 470 screws were included in the final evaluation. Two blinded observers classified screw placement according to the Gertzbein Robbins grading system. Grades A and B were considered acceptable and Grades C-E unacceptable. Weighted kappa was used to calculate reliability between the observers. Mean accuracy was 94.9% (149/157) for iCT/Curve, 97.5% (154/158) for C-arm CBCT/Pulse and 89.0% for CBCT/StealthStation (138/155). The differences between the different combinations were not statistically significant except for the comparison of C-arm CBCT/Pulse and CBCT/StealthStation (p = 0.003). Relevant perforations of the medial pedicle wall were only seen in the CBCT group. Weighted interrater reliability was found to be 0.896 for iCT, 0.424 for C-arm CBCT and 0.709 for CBCT. Under quasi-identical conditions, higher screw accuracy was achieved with the combinations iCT/Curve and C-arm CBCT/Pulse compared with CBCT/StealthStation. However, the exact reasons for the difference in accuracy remain unclear. Weighted interrater reliability for Gertzbein Robbins grading was moderate for C-arm CBCT, substantial for CBCT and almost perfect for iCT.
Flexible battery-less wireless glucose monitoring system
Authors: Banerjee Saikat , Slaughter Gymama
Published: July 2022

In this work, a low power microcontroller-based near field communication (NFC) interfaced with a flexible abiotic glucose hybrid fuel cell is designed to function as a battery-less glucose sensor. The abiotic glucose fuel cell is fabricated by depositing colloidal platinum (co–Pt) on the anodic region and silver oxide nanoparticles-multiwalled carbon nanotubes (Ag2O-MWCNTs) composite on the cathodic region. The electrochemical behavior is characterized using cyclic voltammetry and chronoamperometry. This glucose hybrid fuel cell generated an open circuit voltage of 0.46 V, short circuit current density of 0.444 mA/cm2, and maximum power density of 0.062 mW/cm2 at 0.26 V in the presence of 7 mM physiologic glucose. Upon device integration of the abiotic glucose hybrid fuel cell with the NFC module, the data from the glucose monitoring system is successfully transmitted to an android application for visualization at the user interface. The cell voltage correlated (r2 = 0.989) with glucose concentration (up to 19 mM) with a sensitivity of 13.9 mV/mM•cm2.
Efficacy of salmeterol and magnesium isoglycyrrhizinate combination treatment in rats with chronic obstructive pulmonary disease
Authors: Yang Ye , Huang Lei , Tian Chongchong , Qian Bingjun
Published: July 2022

The most classic treatment recommended in the current chronic obstructive pulmonary disease (COPD) guidelines is glucocorticoid and β2 receptor agonist combination, such as salmeterol xinafoate and fluticasone propionate (Sal/Flu), causing many adverse reactions due to hormones. Magnesium isoglycyrrhizinate (MgIG) is an anti-inflammatory glycyrrhizic acid preparation for treating chronic inflammation, contributing to its structure is similar to steroidal anti-inflammatory drugs. In this study, we successfully established COPD rat model by endotracheal-atomized lipopolysaccharide exposure and cigarette smoke induction, as characterized by lung function decline. We discovered that salmeterol xinafoate/MgIG combination could alleviated lung inflammation infiltration, airway wall thickness (AWT) and the secretion of bronchial mucin MUC5AC of COPD rats more than salmeterol xinafoate, MgIG, or salmeterol xinafoate and fluticasone propionate treatment did, as well as reduced inflammatory cells (white blood cells, neutrophils and lymphocytes) accumulation in bronchoalveolar lavage fluid and decreased TNF-α, IL-6 and IL-1β production in the serum of COPD rats. Finally, we found that Moreover, the mechanism involved might be related to the suppression of JAK/STAT signaling pathway. Overall, our studies suggested that MgIG might be a potential alternative adjuvant drug for fluticasone propionate for the clinical treatment of patients with COPD.
Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers
Authors: Alblihy Adel , Ali Reem , Algethami Mashael , Shoqafi Ahmed , Toss Michael S. , Brownlie Juliette , Tatum Natalie J. , Hickson Ian , Moran Paloma Ordonez , Grabowska Anna , Jeyapalan Jennie N. , Mongan Nigel P. , Rakha Emad A. , Madhusudan Srinivasan
Published: July 2022

Platinum resistance is a clinical challenge in ovarian cancer. Platinating agents induce DNA damage which activate Mre11 nuclease directed DNA damage signalling and response (DDR). Upregulation of DDR may promote chemotherapy resistance. Here we have comprehensively evaluated Mre11 in epithelial ovarian cancers. In clinical cohort that received platinum- based chemotherapy (n = 331), Mre11 protein overexpression was associated with aggressive phenotype and poor progression free survival (PFS) (p = 0.002). In the ovarian cancer genome atlas (TCGA) cohort (n = 498), Mre11 gene amplification was observed in a subset of serous tumours (5%) which correlated highly with Mre11 mRNA levels (p < 0.0001). Altered Mre11 levels was linked with genome wide alterations that can influence platinum sensitivity. At the transcriptomic level (n = 1259), Mre11 overexpression was associated with poor PFS (p = 0.003). ROC analysis showed an area under the curve (AUC) of 0.642 for response to platinum-based chemotherapy. Pre-clinically, Mre11 depletion by gene knock down or blockade by small molecule inhibitor (Mirin) reversed platinum resistance in ovarian cancer cells and in 3D spheroid models. Importantly, Mre11 inhibition was synthetically lethal in platinum sensitive XRCC1 deficient ovarian cancer cells and 3D-spheroids. Selective cytotoxicity was associated with DNA double strand break (DSB) accumulation, S-phase cell cycle arrest and increased apoptosis. We conclude that pharmaceutical development of Mre11 inhibitors is a viable clinical strategy for platinum sensitization and synthetic lethality in ovarian cancer.
Intelligent evaluation of free amino acid and crude protein content in raw peanut seed kernels using NIR spectroscopy paired with multivariable calibration
Authors: Haruna Suleiman A. , Li Huanhuan , Wei Wenya , Geng Wenhui , Yao-Say Solomon Adade Selorm , Zareef Muhammad , Ivane Ngouana Moffo A. , Chen Quansheng
Published: July 2022

Given the nutritional importance of peanuts, this study examined the free amino acid (FAA) and crude protein (CP) content in raw peanut seeds.
A highly selective molecularly imprinted electrochemical sensor with anti-interference based on GO/ZIF-67/AgNPs for the detection of p-cresol in a water environment
Authors: Han Shuang , Sun Ruonan , Teng Fu , Wang Yuan , Chu Hongtao , Zong Wei , Chen Yao , Sun Zhonghui
Published: July 2022

In this study, a novel molecularly imprinted electrochemical sensor for p-cresol detection was constructed by combining GO/ZIF-67/AgNPs with molecular imprinting technology.
An AIE photosensitizer with unquenched fluorescence based on nitrobenzoic acid for tumor-targeting and image-guided photodynamic therapy
Authors: Wang Yaqi , Pan Xiaohong , Dai Tao , Wang Le , Shi Haixing , Wang Huanhuan , Chen Zhuo
Published: July 2022

The nitrobenzoic acid group is an excellent building block for constructing tumor-targeting photosensitizers with strong fluorescence and reactive oxygen species (ROS) generation abilities.
A painless and flexible bi-directional blood glucose-regulating system inspired by an inverter air conditioner
Authors: Dong Lina , Ren Yingzi , Zhang Wei , Liu Yu , Liu Mingzhuo , Hong Can , Wang ManYu , Zhan Bowen , Ding Xingwei , Wang Xiaolei
Published: July 2022

A painless, and real-time bi-directional blood glucose regulating drug delivery system was proposed by NIR-defined insulin release and pressure-responsive glucose release.
Synthesis of stack plate covalent organic framework nanotubes using a self-assembled acid as a soft template
Authors: Wu Dan , Han Dandan , Zhou Yong , Zhang Zhen , Qian Hang , Zhou Qian , Zhang Yongsheng , Khodakov Andrei Y. , Ordomsky Vitaly V.
Published: July 2022

COF nanotubes in the form of a stack of plates with a hollow channel have been synthesized using trimesic acid rods as soft templates.
Precise design and preparation of two 3D organic–inorganic perovskite ferroelectrics (1,5-diazabicyclo[3.2.2]nonane)RbX3 (X = Br, I)
Authors: Han Keke , Zhang Mengxia , Wei Zhenhong , Ye Xing , Rao Wenjun , Zhang Haina , Cai Hu
Published: July 2022

Two 3D organic–inorganic hybrid perovskite ferroelectrics [3.2.2-dabcn]RbX3 (X = Br for 1; X = I for 2) with Curie temperatures at 342 K and 293 K were designed and prepared by reaction of 1,5-diazabicyclo[3.2.2]nonane with RbX.
Heavier N-heterocyclic half-sandwich tetrylenes
Authors: Bischoff Inga-Alexandra , Morgenstern Bernd , Schäfer André
Published: July 2022

The best of both worlds: Lewis amphiphilic N-heterocyclic half-sandwich tetrylenes are reported, which combine structural features of di-N-heterocyclic tetrylenes and tetrelocenes.
Synthesis of the two isomers of heteroleptic Rh12L6L′6metal–organic polyhedra by screening of complementary linkers
Authors: Broto-Ribas Anna , Gutiérrez María Susana , Imaz Inhar , Carné-Sánchez Arnau , Gándara Felipe , Juanhuix Judith , Maspoch Daniel
Published: July 2022

A series of porous, heteroleptic, rhodium-based trigonal antiprismatic metal–organic polyhedral was assembled, from which both possible isomers were identifiedviascreening of complementary linkers.
Actinide arene-metalates: 2. A neutral uranium bis(anthracenide) sandwich complex and elucidation of its electronic structure
Authors: Murillo Jesse , Bhowmick Rina , Harriman Katie L. M. , Gomez-Torres Alejandra , Wright Joshua , Miró Pere , Metta-Magaña Alejandro , Murugesu Muralee , Vlaisavljevich Bess , Fortier Skye
Published: July 2022

Reaction of [UI2(HMPA)4]I with potassium anthracenide gives the unprecedented arenide-sandwich complex U(η6-C14H10)(η4-C14H10)(HMPA)2. CASSCF calculations indicate the U–C bonding to solely consist of π-interactions.
Design and applications of water irradiation devoid RF pulses for ultra-high field biomolecular NMR spectroscopy
Authors: Manu V. S. , Olivieri Cristina , Pavuluri KowsalyaDevi , Veglia Gianluigi
Published: July 2022

Water devoid RF pulses designed by an evolutionary algorithm and AI improve solvent suppression and increase the NMR spectra sensitivity.
Excited state dynamics of a spontaneously generated TTF radical cation inside a water-soluble nanocage
Authors: Paul Sunandita , Voora Vamsee K. , Dasgupta Jyotishman
Published: July 2022

Facile generation and inter-conversion between different molecular redox states can drive multi-electron catalysis. Here we generate a stable TTF radical cation inside a cavity, and enumerate its ultrafast dynamics after photoexcitation.
Step-by-step from amorphous phosphate to nano-structured calcium hydroxyapatite: monitoring by solid-state 1H and 31P NMR and spin dynamics
Authors: Klimavicius Vytautas , Maršalka Arūnas , Kizalaite Agne , Zarkov Aleksej , Kareiva Aivaras , Aidas Kęstutis , Hirschinger Jérôme , Balevicius Vytautas
Published: July 2022

Structural and dynamical evolution in a series of samples including amorphous phosphate, composite, and nano-structured calcium hydroxyapatite is probed by NMR cross-polarization kinetics.
Atomically thin 2D photocatalysts for boosted H2 production from the perspective of transient absorption spectroscopy
Authors: Goswami Tanmay , Bhatt Himanshu , Yadav Dharmendra Kumar , Ghosh Hirendra N.
Published: July 2022

The efficiency of a 2D photocatalyst is largely dependent on the excited state charge carrier behavior at short time scale, which can be accessed and used for the betterment of the photocatalyst via only transient absorption spectroscopy.
Electrochemical impedance and X-ray absorption spectroscopy analyses of degradation in dye-sensitized solar cells containing cobalt tris(bipyridine) redox shuttles
Authors: Gao Jiajia , Tot Aleksandar , Tian Haining , Gardner James M. , Phuyal Dibya , Kloo Lars
Published: July 2022

Electrochemical impedance spectroscopy (EIS) is a commonly used steady-state technique to examine the internal resistance of electron-transfer processes in solar cell devices, and the results are directly related to the photovoltaic performance.
Biaxial stress and functional groups (T = O, F, and Cl) tuning the structural, mechanical, and electronic properties of monolayer molybdenum carbide
Authors: Kotmool Komsilp , Kaewmaraya Thanayut , Hussain Tanveer , Ahuja Rajeev , Luo Wei , Bovornratanaraks Thiti
Published: July 2022

This work reports the ab initio study of the crystal energetics, electronic properties, mechanical properties, and the impacts of strain on electronic properties of Mo2CT2 (T = O, F, and Cl).
Correction: Transfer learned potential energy surfaces: accurate anharmonic vibrational dynamics and dissociation energies for the formic acid monomer and dimer
Authors: Käser Silvan , Meuwly Markus
Published: July 2022

Correction for ‘Transfer learned potential energy surfaces: accurate anharmonic vibrational dynamics and dissociation energies for the formic acid monomer and dimer’ by Silvan Käser et al., Phys. Chem. Chem. Phys., 2022, 24, 5269–5281, https://doi.org/10.1039/D1CP04393E.
Water as a solvent: transition metal catalyzed dehydrogenation of alcohols going green
Authors: Borthakur Ishani , Kumari Saloni , Kundu Sabuj
Published: July 2022

This review highlights the advances in transition metal-catalysed dehydrogenative functionalization of alcohols using water as a solvent.
Acridine based metal–organic framework host–guest featuring efficient photoelectrochemical-type photodetector and white LED
Authors: Wang Hua-Rui , Tian Xu-Ke , Zhang Ji-Rui , Wen Meng-Yao , Yang Xiao-Gang
Published: July 2022

The host–guest interactions, charge transfer and photophysical performance of acridine based MOF were well studied, which can be applied as efficient photodetector and white LED.
Achieving visible and near-infrared dual-emitting mechanoluminescence in Mn2+ single-doped magnesium aluminate spinel
Authors: Wang Tianli , Liu Fei , Wang Ziqi , Zhang Jia , Yu Shuaishuai , Wu Junxiao , Huang Jiahao , Wang Wenjie , Zhao Lei
Published: July 2022

In this work, the self-recovered visible-NIR dual-emitting ML material MgAl2O4:Mn2+ was successfully developed. Thus, the application potential in electronic signature, multiple security and information encryption is improved.
Molecular precursor-mediated facile synthesis of photo-responsive stibnite Sb2S3 nanorods and tetrahedrite Cu12Sb4S13 nanocrystals
Authors: Thomas Agnes , Karmakar Gourab , Shah Alpa Y. , Lokhande Saili Vikram , Kulkarni Atharva Yeshwant , Tyagi Adish , Singh Chauhan Rohit , Kumar N. Naveen , Singh Avadhesh Pratap
Published: July 2022

A facile synthetic route to access phase pure Sb2S3 and Cu12Sb4S13 nanostructures from a new molecular precursor Sb(4,6-Me2pymS)3 has been established. These nanostructures demonstrate high photoresponsivity with fast switching characteristics.
IL-6/STAT3/Foxo1 axis as a target of lycopene ameliorates the atrazine-induced thymic mitophagy and pyroptosis cross-talk
Authors: Zhu Shi-Yong , Li Chen-Xi , Tong Yu-Xuan , Xu Ya-Ru , Wang Zhao-Yi , Li Jin-Long
Published: July 2022

The thymus is central architecture for lymphoid cells. Atrazine exposure induces thymic mitophagy and pyroptosis cross-talk. Lycopene has the potential role in prevention the atrazine's toxic effect by targeting the IL-6/STAT3/Foxo1 axis.
Morphology and carrier mobility of high-B-content BxAl1−xN ternary alloys from an ab initio global search
Authors: Qi Zhanbin , Shi Zhiming , Zang Hang , Ma Xiaobao , Yang Yuxin , Jia Yuping , Jiang Ke , Sun Xiaojuan , Li Dabing
Published: July 2022

An energetically favorable BxAl1−xN structure from wurtzite to hexagonal for the new B@50% polymorph is found with a space group of Ccm21.
A tight-binding model for the electronic structure of MXene monolayers
Authors: Mostafaei Alireza , Heidari Semiromi Ebrahim
Published: July 2022

We present a 13-band TB model with 20 Slater-Koster parameters for 2D MXenes. The obtained hopping parameters can be used to study the physical properties of MXene-based materials and nanostructures in the framework of the TB model.
Rationally designed nanoarray catalysts for boosted photothermal CO2 hydrogenation
Authors: Shen Xukai , Li Chaoran , Wu Zhiyi , Tang Rui , Shen Jiahui , Chu Mingyu , Xu Ao-Bo , Zhang Bingchang , He Le , Zhang Xiaohong
Published: July 2022

A combined structural engineering strategy and thinning strategy were used to optimize nanoarray-based photothermal catalysts, showing a high CO2 conversion rate of 1780 mmol gCo-1 h-1.
Dimensionality reduction boosts the peroxidase-like activity of bimetallic MOFs for enhanced multidrug-resistant bacteria eradication
Authors: Sun Hao , Dan Jie , Liang Yanmin , Li Min , Zhuo Junchen , Kang Yi , Su Zehui , Zhang Qiuping , Wang Jianlong , Zhang Wentao
Published: July 2022

A zero-dimensional bimetallic MOF-based nanozyme Co–Fe NDs with good antibacterial activity and biocompatibility was prepared by reducing the dimensionality. Meanwhile, the Km of Co–Fe NDs was almost triple that of the precursor Co–Fe NSs.
Cyclization/hydrolysis of 1,5-enenitriles initiated by sulfonyl radicals in the aqueous phase in the presence of the I2/TBHP system
Authors: Hu Sen-Jie , Jiang Li-Lin , Qiu Hui , Luo Chun-Mei , Guan Yu-Tao , Li Long , Dong Youren , Lei Ke-Wei , Wei Wen-Ting
Published: July 2022

A cyclization/hydrolysis of 1,5-enenitriles for the synthesis of valuable pyrrolidine-2,4-diones in the aqueous phase using I2 as the catalyst and tert-butyl hydroperoxide (TBHP) as the oxidant is reported.
Disarming the alkoxide trap to access a practical FeCl3 system for borrowing-hydrogen N-alkylation
Authors: Ye Zongren , Yang Zhenjie , Yang Chenhui , Huang Ming , Xu Xianfang , Ke Zhuofeng
Published: July 2022

Disarming the alkoxide trap using an in situ reduction strategy to access a practical FeCl3 and N-heterocyclic carbene system for borrowing-hydrogen N-alkylation.
Switchable synthesis of 1,4-bridged dihydroisoquinoline-3-ones and isoquinoline-1,3,4-triones through radical oxidation of isoquinolinium salts with phenyliodine(iii) diacetate
Authors: Lin Xiao-Long , Yu Yan , Zhang Liang , Leng Li-Jing , Xiao Dong-Rong , Cai Tian , Luo Qun-Li
Published: July 2022

A switchable synthesis of 1,4-bridged dihydroisoquinoline-3-ones and isoquinoline-1,3,4-triones is developed via radical oxidation of isoquinolinium salts with PhI(OAc)2.
Theoretical investigation of the optoelectronic response of highly correlated Cu3P photocatalyst
Authors: Ahmad Haseeb , Rauf Ali , Muhammad Shoaib
Published: July 2022

The optical absorption from BSE@PBE0 is in better agreement with the experiment than BSE@DFT+U. The electron–hole interaction and strong correlation between electrons play a vital role in the optoelectronic response of Cu3P.
Facile production of quercetin nanoparticles using 3D printed centrifugal flow reactors
Authors: De Grandi Davide , Meghdadi Alireza , LuTheryn Gareth , Carugo Dario
Published: July 2022

A 3D printed reactor-in-a-centrifuge (RIAC) was developed to produce drug nanocrystals. Quercetin nanocrystals were manufactured at varying operational and formulation conditions, and had a small size (190–302 nm) and low size dispersity (PDI < 0.1).
Jahn-Teller distortion and dissociation of CCl4+ by transient X-ray spectroscopy simultaneously at the carbon K- and chlorine L-edge
Authors: Ross Andrew D. , Hait Diptarka , Scutelnic Valeriu , Haugen Eric A. , Ridente Enrico , Balkew Mikias B. , Neumark Daniel M. , Head-Gordon Martin , Leone Stephen R.
Published: July 2022

Dynamics of CCl4+ prepared by 800 nm strong-field ionization, as studied with X-ray transient absorption spectroscopy (XTAS) and quantum chemical calculations.
Activity mediated globule to coil transition of a flexible polymer in a poor solvent
Authors: Paul Subhajit , Majumder Suman , Janke Wolfhard
Published: July 2022

Understanding the role of self-propulsion on the properties of filamentous objects has relevance in biology. We show that such self-propulsion can induce a globule to coil transition of a flexible polymer under a poor solvent condition.
Study of failure modes in two sulphide-based solid electrolyte all-solid-state batteries via in situ SEM
Authors: Yadav Neelam Ghanshyam , Folastre Nicolas , Bolmont Mickael , Jamali Arash , Morcrette Mathieu , Davoisne Carine
Published: July 2022

A schematic representation of three interlinked broad failure modes observed.
A Cu-based nanoplatform for near-infrared light amplified multi-mode prostate cancer specific therapy
Authors: Xu Bo , Niu Rui , Tang Ying , Wang Chunxi , Jin Longhai , Wang Yinghui
Published: July 2022

We report that Cu-MNCS-AIPH@PAA with high biocompatibility can be used for highly efficient therapy of PCa through the cooperative effect of PTT, CDT, and alkyl radical generation triggered by the photothermal effect.
Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth
Authors: Kowash Hager M. , Potter Harry G. , Woods Rebecca M. , Ashton Nick , Hager Reinmar , Neill Joanna C. , Glazier Jocelyn D.
Published: July 2022

Maternal infection during pregnancy increases the offspring risk of developing a variety of neurodevelopmental disorders (NDDs), including schizophrenia. While the mechanisms remain unclear, dysregulation of placental function is implicated.

We hypothesised that maternal infection, leading to maternal immune activation and stimulated cytokine production, alters placental and yolk sac amino acid transport, affecting fetal brain development and thus NDD risk. Using a rat model of maternal immune activation induced by the viral mimetic polyinosinic:polycytidylic acid (poly(I:C)), we investigated placental and yolk sac expression of system L amino acid transporter subtypes which transport several essential amino acids including branched-chain amino acids (BCAA), maternal and fetal BCAA concentration, placental 14C-leucine transport activity and associated impacts on fetal growth and development.

Poly(I:C) treatment increased acutely maternal IL-6 and TNFα concentration, contrasting with IL-1β. Transcriptional responses for these pro-inflammatory cytokines were found in placenta and yolk sac following poly(I:C) treatment. Placental and yolk sac weights were reduced by poly(I:C) treatment, yet fetal body weight was unaffected, while fetal brain weight was increased. Maternal plasma BCAA concentration was reduced 24 h post-poly(I:C) treatment, yet placental, but not yolk sac, BCAA concentration was increased. Placental and yolk sac gene expression of Slc7a5, Slc7a8 and Slc43a2 encoding LAT1, LAT2 and LAT4 transporter subtypes, respectively, was altered by poly(I:C) treatment. Placental 14C-leucine transport was significantly reduced 24 h post-treatment, contrasting with a significant increase 6 days following poly(I:C) treatment.

Maternal immune activation induces dysregulated placental transport of amino acids affecting fetal brain development, and NDD risk potential in offspring.
Quality of Measurement in Core Lexicon Measures
Authors: Kim Hana , Schoemann Alexander M. , Wright Heather Harris
Published: July 2022

Purpose:

Core lexicon measures have received growing attention in research. They are intended to provide clinicians with a clinician-friendly means to quantify word retrieval ability in discourse based on normal expectations of discourse production for specific discourse elicitation tasks. To date, different criteria have been used to develop core lexicon measures by groups of researchers. The need for statistical guidance in pursuit of the psychologically robust measure has been recognized.

Aims:

This study was to investigate the best criterion for accurate measurement. Specifically, we focused on two criteria (
frequency
vs.
percentage
) that have previously been used for the development of core lexicon measures.

Method:

Core lexicon measures consisting of five different checklists by word class (verbs, nouns, adjectives, adverbs, and function words) and developed by the two criteria were applied to language samples produced by 470 cognitively healthy adults. Performance in word retrieval ability at the discourse level was modeled as a latent variable based on the observed proportions of the production of core lexicon items in two different sets of core lexicon measures using structural equation modeling.

Results:

Results indicated that both criterion for core lexicon measures capture word retrieval ability in discourse. Greater residual variances were found in the core lexicon measure established by the percentage criterion compared to the one established by the frequency criterion. This indicates that the measure based on the percentage criterion is more affected by measurement errors.

Conclusions:

The findings provide evidence that the frequency criterion is better to use for the development of core lexicon measures for core nouns, verbs, adjectives, and adverbs, but not for function words. However, our findings are limited to core lexicon measures based on language samples elicited by wordless picture books. This may not be easily applied to other core lexicon measures that use different discourse elicitation tasks due to the difference in quality and quantity of language samples. Ideally, the same approach should be replicated to evaluate the appropriateness of respective criteria in the development of core lexicon measures.

Supplemental Material:

https://doi.org/10.23641/asha.20304144