bluuebunny/crossref_metadata_2025 huggingface dataset:
ЭРИТРОЦИТЫ ЛЫЖНИКОВ-ГОНЩИКОВ МУЖЧИН И ЖЕНЩИН В ГОДОВОМ ЦИКЛЕ
Authors: Mongalev Nikolay Petrovich , Rubtsova Lidiya Yurevna , Potolitsyna Natalya Nikolaevna
Published: December 2019

Цель. Определение гендерных особенностей морфофункционального состояния красной крови у спортсменов в течение 10 месяцев годового мониторинга.Материалы и методы исследования. Морфофункциональный состав красной крови изучали у спортсменов высокой квалификации от первого разряда до мастеров спорта по лыжным гонкам, участников сборных команд Республики Коми – мужчин (n=87) в возрасте 23,1±0,57 и женщин (n=62) 20,9±0,61 лет в течение 10 месяцев годового цикла. Исследование проведено согласно протоколу, утвержденному локальным комитетом по биоэтике Федерального исследовательского центра «Коми научного цента УрО РАН». У спортсменов утром натощак производили фоновый забор крови из локтевой вены в вакутайнеры (Англия). На мазках крови, окрашенных по Романовскому-Гимза (Vital-Development), бриллиантовым крезиловым синим (Россия) измеряли диаметр по 50 эритроцитов и ретикулоцитов с помощью микроскопа МБ с масляной иммерсией, увеличение об. 100х ок. с градуированной шкалой 12х. Определение гематокрита проводили с помощью центрифуги MPW-310 (Poland), гемоглобина унифицированным гемиглобинцианидным методом (REF) (Россия), количество эритроцитов подсчитывали с помощью камеры Горяева в соответствии с требованиями клинико-гематологического обследования. Обработку результатов осуществляли методами параметрической статистики с использованием прикладных лицензионных программ Excel и Statistica for Windows 6.0., которые представлены в виде среднего арифметического (M), ошибки средней (m). Для сравнения различий применяли t-критерий Стьюдента с уровнем значимости от 0,05 до 0,001.Результаты. Показано наличие статистически значимых различий у спортсменов высокой квалификации между показателями мужчин и женщин в годовом цикле по уровню гематокрита, гемоглобина, количеству эритроцитов, объёму, диаметру эритроцитов и их поверхности, в том числе в литре крови (p<0,001). Выявлены гендерные особенности в характере изменения клеточного состава красной крови по величине эритроцитов окрашенных in vitro витальными красителями (p<0,05), диаметру и количеству ретикулоцитов, концентрации гемоглобина в эритроците (p<0,001).Заключение. Мониторинг обследования лыжников-гонщиков по половым признакам показал сохранение существующих различий в морфофункциональном состоянии красной крови у мужчин и женщин в годовом цикле, что может свидетельствовать об адекватном процессе подготовки спортсменов до уровня высокой квалификации.
ИНТЕРВЕНЦИОННЫЕ МЕТОДЫ ЛЕЧЕНИЯ ВЕРТЕБРОГЕННОЙ БОЛИ: ОБЗОР ЛИТЕРАТУРЫ И СОБСТВЕННЫЙ ОПЫТ
Authors: Yarikov Anton Viktorovich , Morev Anton Vladimirovich , Khasyanov Marat Kasimovich , Zemlyanin Konstantin Olegovich , Naumov Aleksey Konstantinovich , Ponomareva Aleksandra Ivanovna , Stolyarov Sergey Igorevich , Slipenko Elena Viktorovna , Zhukova Yuliya Aleksandrovna
Published: December 2019

Работа посвящена рассмотрению вариантов лечения вертеброгенного болевого синдрома. Частая встречаемость его связана с изменениями условий жизни и работы в современном мире. Длительные осевые нагрузки на позвоночник, гиподинамия, повышенная масса тела негативно влияют на баланс позвоночного столба, что на начальном этапе выражается в появлении болевого синдрома. Авторы, в своей работе, выделяют основные виды блокад в зависимости от их цели. Отдельно подчеркнуты современные технологические средства для верификации анатомических структур, позволяющие таргетированно воздействовать на источник боли. Описаны различные методы проведения блокад такие как эпидуральная, каудальная, трaнсфoрaминальная эпидурaльнaя, миoфaсциальная, блокада крестцово-подвздошного сочленения, межпозвонковых суставов и грушевидной мышцы. Выделены показания к их применению, а также важные тактические нюансы. Проведен анализ возможностей применения различных лекарственных препаратов в купировании вертеброгенной боли. Указаны вероятные риски их применения. В заключении авторы подчеркивают важность малоинвазивных интервенционных вмешательств в комплексном лечении вертеброгенного болевого синдрома.
ВЛИЯНИЕ СОЦИАЛЬНО-ЭКОНОМИЧЕСКИХ ФАКТОРОВ НА КАЧЕСТВО ЖИЗНИ БОЛЬНЫХ ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНЬЮ ЛЕГКИХ В УСЛОВИЯХ КОМОРБИДНОСТИ
Authors: Kozlov Evgeny Vyacheslavovich , Derevyannich Evgeny Valeryevich , Balashova Natalia Arlenovna , Yaskevich Roman Anatolyevich , Moskalenko Olga Leonidovna
Published: December 2019

Цель. Изучение влияния социально-экономических факторов на качество жизни у больных хронической обструктивной болезнью легких (ХОБЛ) в условиях коморбидности с артериальной гипертонией (АГ).Материалы и методы. В исследование было включено 136 пациентов мужского пола, средний возраст 61 лет. Из них пациентов с ХОБЛ в сочетании с АГ–- 63 человека, пациентов с ХОБЛ без АГ 29 человек. Группу сравнения составили 44 пациента с АГ без ХОБЛ. Исследование качества жизни проводилось методом самоанкетирования с использованием общего вопросника MOS SF-36, так же учитывали социально-экономический статус пациентов.Результаты. В ходе проведенного исследования выявлено снижение КЖ по всем параметрам у пациентов с ХОБЛ и в большей степени у лиц при коморбидности ХОБЛ и АГ, что вероятнее всего связано с прогрессированием и большей выраженностью клинической симптоматики. Наиболее значимой сферой отношений на всех стадиях является социально-экономический статус, значимость которого увеличивается по мере нарастания тяжести болезни. Более низкие значения по шкалам, характеризующим как физический, так и психосоциальный статус респондентов, регистрировались у неработающих лиц. КЖ прямо пропорционально снижалось (р<0,05), при наличии группы инвалидности, при чем более выраженно у пациентов при коморбидности ХОБЛ и АГ. Рассматривая влияние среднего прожиточного минимума, из расчета на одного члена семьи, на уровень КЖ, статистически значимые внутригрупповые отличия были получены среди пациентов с изолированной ХОБЛ по шкалам общего здоровья и физического функционирования (p<0,05).Заключение. Социально-экономический статус оказывает существенное влияние на КЖ респондентов, при чем как в целом, так и на отдельно составляющие его части.
БРОНХИАЛЬНАЯ АСТМА: МОНИТОРИРОВАНИЕ КАЧЕСТВА ДИСПАНСЕРИЗАЦИИ БОЛЬНЫХ ВРАЧОМ АЛЛЕРГОЛОГОМ-ИММУНОЛОГОМ
Authors: Gantseva Khalida Khanafievna , Khanova Ayritta Karimovna , Yavgildina Alfiya Mustamirovna
Published: December 2019

Статья посвящена мониторированию качества диспанцеризации больных с бронхиальной астмой.Цель. Разработка объективного длительного мониторирования пациентов, оценка качества проведения образовательных программ, страдающих бронхиальной астмой в процессе диспансерного наблюдения.Материалы и методы. Для комплексной оценки динамического этапного мониторирования пациентов с диагнозом «Бронхиальная астма» использованы анкеты из трех блоков вопросов, а также анализ оценок в рамках клинических примеров с целенаправленным повторным анкетированием пациентов. Первый этап оценки проводился перед началом реализации образовательной программы. Второй этап оценки – после завершения учебного процесса по той же анкете, с целью выявления конечного уровня их знаний для коррекции процесса обучения при реализации последующей цепочки образовательных программ. Третий этап проводится через 1 год, на повторном тестировании и для обеспечения дифференцированной тактики дальнейшего ведения пациентов.Результаты. На клиническом примере пациентки с бронхиальной астмой проведен расчет результатов анкетирования на первом, втором и третьем этапах исследования у пациента с исходно низким уровнем подготовленности по всем трем блокам знаний, умении, оценки качества жизни, с достижением высокого уровня компетентности в результате курса обучения, пациентка признана не нуждающейся в повторном обучении, и ей было предложено продолжение только диспансерного наблюдения.Заключение. Технический результат при использовании методики – улучшение уровня качества жизни пациентов с бронхиальной астмой. Поэтапное анкетирование пациентов по выявлению уровня их информированности позволяет выстроить стройную дифференцированную систему их обучения в «Астме-школе», которая не осуществима другими способами диагностики.
ДИАГНОСТИКА КАЧЕСТВА ОБУЧЕНИЯ БОЛЬНЫХ БРОНХИАЛЬНОЙ АСТМОЙ В ПРОФЕССИОНАЛЬНОЙ ДЕЯТЕЛЬНОСТИ ВРАЧА АЛЛЕРГОЛОГА-ИММУНОЛОГА
Authors: Gantseva Khalida Khanafievna , Khanova Ayritta Karimovna , Yavgildina Alfiya Mustamirovna
Published: December 2019

Статья посвящена диагностике качества обучения пациентов с бронхиальной астмой.Цель. Разработка объективного способа оценки качества проведения образовательных программ для пациентов с бронхиальной астмой к обеспечению процедур самоконтроля и комплаенса с лечащим врачом.Материалы и методы. Данное исследование проводилось на территории Республики Башкортостан с разрешения этического комитета ФГБОУ ВО БГМУ Минздрава РФ. Каждый участник перед началом исследования подписал форму информированного согласия на обследование.Анкетным методом, включающим 140 признаков, отражающих владения теоретическими знаниями и владение практическими умениями, требуемых к завершению обучения в «Астме-школе», где каждый показатель оценивается в баллах, и совокупный их уровень дает итоговый, заключающий оценочный уровень с интерпретацией 3 блоков вопросов.Результаты. Вопросы первого блока имеют градации: хорошее знание, удовлетворительное знание, незнание: второго блока – хорошее владение навыком, удовлетворительное, отсутствие навыка; в третьем блоке – оценка клинических проявлений заболевания, используемых в совокупности самооценки пациентом качества жизни как высокая, средняя и низкая. Суммируя полученные баллы от каждого из 140 использованных в исследовании признаков, при количестве баллов от 40 до 66, оценивали уровень знаний, навыков пациентов как низкий, 67–93 – как средний, 94–120 – как высокий. Приведены 2 клинических примера из практики их использования в реальной ситуации.Заключение. Предлагаемая методика оценки качества обучения пациентов «Астма-школы» позволяет объективизировать результаты образовательного процесса относительно пациентов и модернизировать, повысить эффективность работы врача с пациентами бронхиальной астмой.
Diagnostic Accuracy of Procalcitonin and C-reactive Protein Is Insufficient to Predict Proven Infection: A Retrospective Cohort Study in Critically Ill Patients Fulfilling the Sepsis-3 Criteria
Authors: van Oers Jos A H , de Jong Evelien , Kemperman Hans , Girbes Armand R J , de Lange Dylan W
Published: December 2019

Background

New Sepsis-3 definitions facilitate early recognition of patients with sepsis. In this study we investigated whether a single initial determination of procalcitonin (PCT) or C-reactive protein (CRP) in plasma can predict proven sepsis in Sepsis-3 criteria-positive critically ill patients. We also investigated whether a decline in serial PCT or CRP can predict outcome in 28-day mortality.

Methods

Patients, ≥18 years of age, at the intensive care unit with a suspected infection, a Sequential Organ Failure Assessment (SOFA) score of ≥2 points, and an index test PCT and CRP at admission were selected from a prospectively collected cohort. PCT and CRP were studied retrospectively with the Mann–Whitney U-test and ROC analysis.

Results

In total, 157 patients were selected; 63 of the 157 had proven sepsis, and sepsis could not be detected in 94 of the 157. Neither a single PCT nor CRP at admission was able to discriminate proven sepsis from nonproven sepsis (PCT, 1.8 μg/L and 1.5 μg/L, respectively, P = 0.25; CRP, 198 mg/L and 186 mg/L, respectively, P = 0.53). Area under the curve for both PCT and CRP for detecting proven sepsis was low (0.55 and 0.53). Furthermore, neither a decline from baseline to day 5 PCT nor CRP could predict 28-day mortality (PCT, 50% vs 46%, P = 0.83; CRP, 30% vs 40%, P = 0.51).

Conclusion

PCT and CRP at admission were not able to discern patients with proven sepsis in Sepsis-3 criteria-positive critically ill patients. A decline of PCT and CRP in 5 days was not able to predict 28-day mortality.
Consultative Interpretation for Lupus Anticoagulant by Expert Pathologist Reduces False-Positive Rates in the Era of Direct Oral Anticoagulants
Authors: Vivero Angelica , Kitahara Sumire , Runge Alice , Volod Oksana
Published: December 2019

Background

The diagnosis of antiphospholipid syndrome requires detection of antiphospholipid antibodies (aPL). A retrospective review of our testing practices revealed that societal recommendations for lupus anticoagulant (LA) testing as part of aPL testing are largely not followed by clinicians, and there was a high proportion of positive LA results. Increasing direct oral anticoagulant (DOAC) usage creates additional challenges in identifying LA. This prompted us to establish an order set with pathologist consultation (“LA panel”) and testing algorithm to reduce false-positive LA and to ensure optimal LA identification and best practices for interpretation and follow-up.

Methods

The laboratory database was reviewed to determine the number of LA tests ordered and rate of LA positivity before and after the LA panel was instituted. We assessed the impact of pathologist consultation to minimize false-positive findings and on following diagnostic guidelines.

Results

LA panels were ordered for 1146 patients. LA was detected in 10% (111 of 1146) by dilute Russel viper venom time (dRVVT) normalized ratio [includes dRVVT screen (dRVVTs) positive/lupus-sensitive partial thromboplastin time (PTT-LA) positive and dRVVTs positive/PTT-LA negative] and 20% (228 of 1146) by Staclot-LA (includes dRVVTs negative/PTT-LA positive and dRVVTs positive/confirm negative). There was a reduction of false-positive LA by Staclot-LA; previously, 48% positive. We saw increased cancellation of LA testing for interfering anticoagulants [6.8% (16 of 236) vs 14.4% (55 of 383); P = 0.0061]. There was also increased adherence to follow-up LA testing [3% (8 of 236) vs 13.8% (53 of 383); P ≤ 0.001].

Conclusions

Creating a predetermined order set and testing algorithm with pathologist consultation improved LA testing interpretation and diagnostic follow-up testing.
Bad Tests Die Slowly: The Myelin Basic Protein Example
Authors: Johnson Lisa M , White Sandra K , Greene Dina N , Schmidt Robert L
Published: December 2019

Background

Our national reference laboratory sought to improve stewardship for multiple sclerosis (MS) testing, which included orders for myelin basic protein (MBP) and oligoclonal bands (OCB). From 2011 to 2012, we performed 2 interventions for MS testing: one gentle-strength intervention of a publication designed to educate others about the lack of utility for MBP results and a second medium-strength intervention that included removal of MBP from the panel of MS tests. The ordering trends and practice variation were examined for OCB and MBP to retrospectively observe the effect of the interventions.

Methods

Data from clients within academic and community hospitals were examined (n = 1710 clients). Ordering patterns for OCB and MBP were investigated from 2008 to 2018 by calculating the %OCB: %OCB = (OCB)/(OCB + MBP). Practice variation was examined by comparing the distribution of clients with different %OCB statistics before and after the interventions in 5-year blocks (2008–2012 vs 2014–2018).

Results

From 2000 to 2011, the %OCB was approximately 50%, but gradually increased to 67% in 2018. For practice variation, analysis of the distribution of clients by %OCB also demonstrated a shift toward clients favoring OCB alone vs OCB + MBP for MS testing for the later time period of 2014–2018.

Conclusion

Our 2 interventions had a measurable, beneficial effect on ordering trends for MS testing over a 10-year period at a single reference laboratory. However, given that MBP has questionable clinical utility, stronger interventions are likely needed to bring about larger changes in ordering behavior.
Coprological detection of equine nematodes among slaughtered donkeys (Equus asinus) in Kaltungo, Nigeria
Authors: Egbe-Nwiyi Tobias Nnia , Paul Bura Thlama , Cornelius Ajuji Chungsyn
Published: December 2019

Aim: This study aimed to investigate the prevalence and intensity of nematode infection among slaughtered donkeys in Kaltungo, Nigeria.

Materials and Methods: A total of 72 fecal samples were examined by salt flotation and the modified McMaster fecal egg count technique to morphologically identify nematodes eggs and determine their egg per gram (EPG) outputs.

Results: Out of a total of 72 (100%) donkeys sampled, 36 (50%) tested positive, but the prevalence of nematodes was independent of the age, sex, and breed of donkeys (p>0.05). Among the four species of nematodes identified in single and mixed infections, Strongylus spp. (27.8%) and Dictyocaulus arnfieldi (13.9%) were the most prevalent followed by Strongyloides westeri (5.6%) and Trichonema spp. (5.6%). Infected donkeys had moderate overall mean EPG (801.39±611.3) with no statistical differences between age groups and sexes (p>0.05), but means of EPG were significantly higher (p<0.05) in Duni (1026.92±719.55) than Idabari (673.91±514.75). Light EPG count was recorded among 63.9% of infected donkeys, while 16.7% and 19.4% had moderate and severe infections, respectively.

Conclusion: The prevalence and importance of equine nematodes were discussed in connection to their epidemiology and control. Furthermore, the preponderance of light infection may suggest that donkeys in this environment developed resistance to nematode infection and are potential reservoirs for other equines.
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Authors: Szécsényi Tibor , Kovács Viktória , Bús Ivett Virág
Published: December 2019

A tanulmány a Maleczki (1995)-ben a főnévi kifejezések interpretációjának le­írásánál használt félhálós strukturált modellt terjeszti ki a személyes névmások interpretációjának leírására. Megállapítja, hogy a különböző személyes névmá­sok által referált atomi és plurális entitások a teljes interpretációs félháló hierar­chikusan elhelyezkedő részfélhálóit alkotják, illetve hogy a tegező és a magázó formák, illetve az az/azok mutató névmások nem illeszthetők be szervesen ebbe a struktúrába. A tanulmány második részében az interpretációs félhálók homo­morf egyszerűsített változatával a magyar alanyi egyeztetési jelenségeket ma­gyarázza, kitérve a vegyes szám- és személyjegyű koordinációk egyeztetési tulajdonságaira, illetve a visszaható névmások és azok antecedensei közötti egyeztetési jelenségeket írja le. A vegyes koordináció során kialakuló alanyi egyeztetési jegy, illetve a visszaható névmási alak meghatározásához ezekben az egyeztetési félhálókban a legkisebb felső korlát félhálóműveletet alkalmazza.
Az örömtől, örömből, örömében
Authors: Viszket Anita , Dóla Mónika
Published: December 2019

Tanulmányunkban a mentális állapotot mint okot megjelenítő konstrukció ([Nmental-state.case]cause) három ragos névszói változatát elemezzük hasonlósá­gaik és különbségeik szempontjából. A szerkezeteket korpuszvezérelt kvali­tatív eljárással elemezzük: egy, a testvér-konstrukciók jelentésére és haszná­latára kiterjedő vizsgálattal, valamint szintaktikailag, különös tekintettel arra, hogy a névelő megléte vagy hiánya hogyan befolyásolja a DP projekció felvé­telét és a referenciális viszonyokat. Azt állítjuk, hogy csak a három konstruk­ció összehasonlító elemzésével lehet releváns következtetéseket levonni az egyes változatok szerkezetére vonatkozóan. Kutatásunk eredménye, hogy a három konstrukció az oksági viszonyt eltérő jelentésmozzanattal reprezentálja (kiváltó–előidéző ok; késztetés–motiváció; háttér–hatás), és ennek következ­ménye, hogy ugyan mindhárom tartalmaz egy meghatározott thematikus szerepű „alanyt”, amelynek az oksági összefüggés miatt a tagmondatban kell megtalálnia az antecedensét, a három konstrukció „alanyára” és a bennfog­laló mondat igéjére azonban az eltérő jelentésmozzanat más-más restrikciót ír elő. Ha a szerkezetben van birtokos személyrag is, akkor az antecendensre nemcsak szemantikai, hanem morfoszintaktikai megkötések is vonatkoznak.
Egzisztenciális predikáció és térbeli lokalizáció a magyarban
Authors: Gécseg Zsuzsanna
Published: December 2019

A tanulmány arra a kérdésre keresi a választ, hogy milyen szintaktikai, sze­mantikai és pragmatikai tényezők befolyásolják a térbeli lokalizációt jelölő összetevő jelenlétét és az alanyhoz viszonyított helyzetét a magyar egziszten­ciális szerkezetekben. A vizsgálat egy 205 egzisztenciális megnyilatkozást tartalmazó 'pilot' korpusz elemzésén alapul. A vizsgált tényezők: az alany szintaktikai pozíciója és referenciális tulajdonságai (puszta köznév vs. néve­lős köznév), valamint a megnyilatkozás kontextuális jellemzői.
A magyar morfológia elsajátításának kezdetei
Authors: Gervain Judit
Published: December 2019

Pszicholingvisztikai szempontból igen jelentős, és máig vitatott kérdés, ho­gyan dolgozzák fel a beszélők a morfológiailag komplex szóalakokat: egész­legesen, elemeikre bontva vagy a két stratégiát flexibilisen használva. Még kevésbé ismert, hogyan sajátítható el a magyar és a hozzá hasonló nyelvek komplex agglutináló morfológiája. A magyar morfológia elsajátítását óvodás korú és annál nagyobb gyermekek beszédében az elmúlt évtizedekben nagy részletességgel feltárták. Sokkal kevesebbet tudunk azonban e tanulási folyamat kezdeteiről. A jelen tanulmány néhány újabb kutatást foglal össze, amelyek magyar csecsemők beszédészlelésében és nyelvfeldolgozásában vizsgálják az alaktan kibontakozásának kezdeteit, különösképpen a magán­hangzó-harmónia és a morfológiai dekompozíció megjelenését.
Két magyar kérdő konstrukció interpretációjához
Authors: Gyuris Beáta
Published: December 2019

A tanulmány a negatív választó kérdésnek (NVK) nevezett konstrukció (pl. Esik az eső vagy nem?) használati feltételeivel foglalkozik a magyarban. Áttekintjük az NVK-k szemantikai értékének meghatározására vonatkozó szakirodalmi javaslatokat, valamint azokat az elméleteket (pl. van Rooy–Šafářová (2003), Biezma (2009)), amelyek az angolban az inverziót tartalma­zó pozitív vagy negatív eldöntendő kérdések és az NVK-k közötti választás hátterét kívánják megadni egy adott szituációban. Azon kontextusok össze­hasonlítása nyomán, ahol az -e partikulás kérdő mondatok és az NVK-k meg­jelenhetnek a magyarban, azt állítjuk, hogy az utóbbi konstrukció akkor van engedélyezve, ha eleget tesz két, a diskurzusra vonatkozó feltétel legalább egyikének. Ezek közül az első diskurzuselőzményekkel, a második pedig a kontextusbeli evidenciákkal kapcsolatos.
Naiv szemantika
Authors: Kálmán László
Published: December 2019

A szerző amellett érvel, hogy a poszt-generatív nyelvészeti iskolák nagy részére (amelyeket összefoglaló néven "naiv nyelvtannak" nevez) az a vonás jellemző, hogy nem törekszenek arra, hogy a lehető legáltalánosabb formában fogalmazzák meg a szabályszerűségeket, és inkább hosszabb, bonyolultabb levezetéseket használjanak arra, hogy ezekből a konkrét jelenségeket levezessék. A cikk ennek az újdonságnak, különbségnek elsősorban azokra a következményeire összpontosít, amelyek a szorosabb értelemben vett nyelvtan és a jelentéstan kapcsolatát (így pl. az ún. kompozicionalitás elvét) érintik.
Percepções de alunos no processo de aprendizagem do desenvolvimento sustentável em cursos de graduação em administração e administração pública e social
Authors: Schiavi Cristiano Sordi , Trevisan Mario Luiz
Published: December 2019

Este artigo analisa a percepção de alunos no final dos cursos de graduação em Administração e Administração Pública Social com relação ao Desenvolvimento Sustentável, escolhendo como estudo de caso uma turma da disciplina de “Gestão Socioambiental nas Empresas” e uma turma da disciplina de “Gestão Socioambiental em Organizações Públicas e Sociais”, na Escola de Administração, da Universidade Federal do Rio Grande do Sul. Por meio da metodologia qualitativa, a coleta de dados foi realizada sob a forma de questionário no primeiro semestre de 2018, bem como foi feita a análise de conteúdo com a utilização do software Nvivo12®. Na análise das respostas dos alunos no final do curso, observou-se um olhar crítico com relação à sustentabilidade tanto no âmbito profissional quanto pessoal. Conclui-se que a educação ambiental torna-se cada vez mais fundamental na formação de profissionais e cidadãos críticos quanto à relação sociedade-natureza nos cursos de Administração, modificando as atitudes e comportamentos em prol do Desenvolvimento Sustentável.
Effects of sewage sludge on the growth of coffea arabica seedlings and cell cycle of Allium cepa
Authors: Gouvea Glaucia De Mello Cunha , Souza Victor Ventura de , Cunha Glaucio De Mello , Souza Tatiana Da Silva
Published: December 2019

Sewage sludge can contain toxic compounds and pathogens therefore it agronomic use must occur in a safer way to the population and environment. The objective of this study was to investigate the effects of substrates containing different proportions of sanitized sewage sludge in the growth of Coffea Arabica seedlings and to verify the cytogenotoxic potential of these substrates using the analysis of Allium cepa cell cycle. The substrate with the lowest proportion of sewage sludge (15%) was the one that obtained the greatest growth performance and did not present cytogenotoxic activity. Substrates with the highest concentrations of sanitized sewage sludge (30, 45 e 60%) were toxics. For coffee seedlings, all the growth variables decreased and the significant induction of aberrant meristematic cells in A. cepa was observed. However, the sewage toxicity was not related to the presence of metals, whose levels were within the maximum limits allowed by the Brazilian legislation, indicating that these biological tests are essential for the determination of the quality of sewages before their agricultural use.
METHODS OF IMPLEMENTATION OF BLOCKCHAIN TECHNOLOGIES ON THE BASIS OF CRYPTOGRAPHIC PROTECTION FOR THE DATA PROCESSING SYSTEM WITH CONSTRAINT AND LAGGING INTO ELECTRONIC DOCUMENT MANAGEMEN
Authors: Akhatov A. R. , Nazarov F. M.
Published: December 2019

The problem of application design by restriction and delay in ED (Electronic Document) management based on blockchain technologies to ensure a new level of security, reliability, transparency of data processing is considered. Increasing the reliability of information in systems by limiting and delaying ED management of enterprises and organizations during collecting, transmitting, storing and processing ED based on new, little-studied optimization technologies for processing blockchain-type data is a relevant and promising research topic. Important advantages of the potential use of transaction blocks built according to certain rules in systems by limiting and delaying ED are ensuring security by encrypting transactions for subsequent confirmation, the inability to make unauthorized changes due to the dependence of the current blockchain state on previous transactions, transparency and reliability of procedures due to public and distributed storage, as well as the interaction of a large number of users between without the use of “trusted intermediaries”. Studies show that when using existing algorithms for adding blocks in any system, it is possible to achieve the requirements of decentralization, openness of the entered data, the inability to change the data once entered into the system. However, mathematics-cryptographic information protection must be developed for each designed system separately. The task of providing and formulating the rules of data reliability control by limiting and delaying in ED circulation based on cryptographic methods of encrypting transaction blocks constituting the blockchain has been formulated. The approaches have been adopted as a methodology of support for systems by limiting and delaying electronic documents based on a new database architecture.
EFFICIENCY INCREASE OF MULTI-OBJECTIVE GENETIC ALGORITHMS USING THE CLUSTERIZATION OF A POPULATION IN THE VARIABLE SPACE
Authors: Kazakov P. V.
Published: December 2019

The paper introduces a new manner for improving of obtained by MOGA (Multi-Objective Genetic Algorithm) solutions. It is based on the concept of dividing the population into set of clusters according to solutions similarity. In different of most MOGA the clusterization of population is implemented in the variable space, enables to enhance diversity of population and to increase the number of non-dominated solutions. The special procedures for the clustering of current population and copying the clusters in the next population were developed. The dominance principal by fitness-value is used for clustering. The number of clusters depends on additional parameter the radius of cluster’s hypersphere that is determined experimentally. By the special rule the individuals corresponded to centroids of clusters are copied in the new population. The clusters are recalculated for every population. The influence of the radius cluster to the number of non-dominated solutions variation was studied. The cluster modification should be integrated into any multi-objective genetic algorithm. By the analytical evaluation has been studied, this MOGA modification has additional computationally complexity from linear to quadratic. In experiments it was tested with the evolutionary algorithms SPEA2, NSGA-II on the special benchmark problems (DTLZ) with a various number of criteria using the set of performance indices. The used clustering in the variable space algorithms were achieved a better distribution and convergence to the true Paretofront in some cases.
TECHNIQUE OF REDUCTION TRANSFORMATIONS FOR MINIMIZATION OF ANALYZED NUMBER OF PARALLEL PROGRAM VARIANTS
Authors: Dordopulo A. I.
Published: December 2019

Formulated several important conclusions of the basic theorems and the main principles of the reduction transformations’ technique. In comparison with automatic parallelizing, the proposed principles provide a considerable decrease in the number of steps required for the applications’ adaptation to architectures of reconfigurable computer systems. At the first stage, the reduction coefficient is factorized, and the rational values of different types of reduction coefficients (by the number of basic subgraphs, by the number of computational operations and by the digit capacity of data) are chosen from the multipliers. At the second stage, the reduction of basic subgraphs’ number is performed according to the coefficient chosen at the previous stage. At the third stage, the number of computational operations and the digit capacity of processed data are reduced to the limit values. The application of the reduction transformations’ technique allows for the integration of multiple variants of parallel program in one group and for the shortening of time needed for its adaptation to the architecture and configuration of a computer system. According to the estimations, the number of reduction transformation steps needed for the calculations’ scaling in reconfigurable computer systems is 26 steps and considerably less than the one for automatic parallelizing compilers.
Recovery of phosphates(V) from wastewaters of different chemical composition
Authors: Hutnik Nina , Stanclik Anna , Piotrowski Krzysztof , Matynia Andrzej
Published: December 2019

Phosphate(V) ions were recovered from wastewaters of different chemical compositions in a continuous reaction crystallization of struvite. Two real wastewaters were represented by an effluent sample from the phosphorus mineral fertilizer industry and by liquid manure derived from a cattle-breeding farm. Two other wastewaters were prepared under laboratory conditions. Impurities present in the wastewaters caused the precipitation of solid products of distinctly different quality. The mean size of struvite crystals varied fromca. 18 toca. 40 μm. Homogeneity within their populations, quantified by the coefficient of variationCV, varied from satisfactory (CV ca. 75%) to unfavorable (CV ca. 100%), which resulted in the elongation of necessary filtration time. Calcium ions in wastewater precipitated as amorphous hydrated calcium phosphates ACP. Their content in the products varied from 33.4 up to 73.1 mass %. Also 28.32 – 32.74 mass % of P2O5, 6.35 – 14.12 mass % of MgO and 4.35 – 16.94 mass % of CaO were confirmed in the products, together with hydroxides of some metals and salts of other impurities. Based on the chemical composition of the products derived from the investigated wastewaters, their application in agriculture as valuable mineral fertilizers is recommended.
Interleukin-4, hemopexin, and lipoprotein-associated phospholipase A2 are significantly increased in patients with unstable carotid plaque
Authors: Stefanic Peter , Sihotsky Vladimir , Hertelyova Zdenka , Kopolovets Ivan , Mathews Abraham John , Toth Stefan , Kubikova Maria , Svajdler Peter , Mucha Rastislav , Vasko Lukas , Virag Michal , Pribula Vit , Pella Dominik , Frankovicova Maria
Published: December 2019

Objective

This study aimed to compare the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2), hemopexin (Hpx), and interleukin-4 (IL-4) in patients with carotid artery atherosclerosis based on neurological symptoms and plaque histopathology and to find association between plaque stability and neurological symptoms. This single-center study included patients treated surgically for significant stenosis of the internal carotid artery. Serum levels of biomarkers were determined, and a histopathological analysis of the carotid plaques was performed. Within 70 patients, 40 asymptomatic and 30 symptomatic; 38 patients (54.3%) were diagnosed with unstable carotid plaque and 32 patients (45.7%) had a stable carotid plaque. Significantly higher incidence of unstable carotid plaque was detected in symptomatic patients (p <0.001). Compared to asymptomatic patients, higher expression of Lp-PLA2 (285.30 ± 2.05 μg/l), Hpx (0.38 ± 0.01 ng/l), and IL-4 (65.77 ± 3.78 ng/l) in plasma were detected in symptomatic patients. Subsequently, higher expression of Lp-PLA2 (297.34 ± 2.3 μg/l), Hpx (0.41 ± 0.02 ng/l), and IL-4 (64.74 ± 4.47 ng/l) in plasma was observed in patients with unstable plaques (n=38). Statistically significant (p <0.001) differences in expression of Lp-PLA2, Hpx, and IL-4 between patients with unstable and stable plaques were detected. Moreover, only the differences between symptomatic and asymptomatic patients in the expression of Lp-PLA2 and IL-4 in plasma were statistically significant (p <0.001). This study showed that Lp-PLA2, IL-4, and Hpx levels are significantly increased in patients with an unstable carotid plaque.
British Exceptionalism Causes Brexit Conundrum
Authors: Ryan John
Published: December 2019

This paper examines the shortcomings in the UK government’s Brexit negotiation strategy which reflected Prime Minister Theresa May’s weak political leadership which focused on securing the short-term political survival of her government amidst turbulent and fractious domestic politics, over negotiations with the EU27. Brexit negotiations were poorly planned, and the UK government was woefully unprepared. Brexit also threatened a serious re-opening of old wounds in Northern Ireland, as debate grows around the prospect of a united Ireland inside the EU. UK politics is in turmoil and in a chronic crisis. What route the Brexit saga takes next is uncertain. But the crossroads is approaching – either the UK leaves by 31 January 2020 with no deal or passes the deal the Boris Johnson has negotiated with the EU27. The Brexit process has revealed the weakness of Westminster’s insular politics seemingly incapable of running a modern economy and society. Westminster’s politics are becoming more not less dysfunctional. The phenomenon of British exceptionalism towards the EU is set to take a new dramatic turn, while the UK’s chaotic political divisions will not disappear any time in the foreseeable future. The result of the 12 December 2019 General Election may even complicate the Brexit Conundrum.
Cut-offs and co-occurring gestures: Similarities between speakers’ first and second languages
Authors: Lopez-Ozieblo Renia
Published: December 2019

This paper explores cut-offs in the oral narrations of Spanish native speakers in their mother tongue (L1), and in their language-under-study, English (L2). Fluency in the L2 varies with proficiency, and so cut-offs offer a possible means of evaluating this. However, there are certain aspects of fluency which might be common to the L1 and the L2, suggesting that the L1 and L2 share cognitive factors that lead to similar disfluency patterns. To determine if cut-offs are reliable markers of L2 fluency, independent of those occurring in the L1, we assessed the cut-off patterns in the L1 and L2 narrations of this group of speakers, following a multimodal approach.

We observed similarities in both languages, potentially indicating that speakers use comparable cut-off-gesture patterns in the L1 and L2. We conclude that using speakers’ cut-offs in an L2 to gauge proficiency is meaningful only if the L1 cut-off behaviour is known.
Defining Rome’s Pantheum
Authors: Siwicki Christopher
Published: December 2019

Writing in the early third century AD, Julius Africanus claimed to have built a library “in the Pantheon” in Rome, the exact location of which remains elusive. In considering the competing possibilities for the site of the library, this paper argues that the building we commonly refer to as the Pantheon does not correspond to the ancient understanding of what the Pantheum was. The case is made that it was not a single building, but instead comprised a larger complex, of which the still-standing structure was only one part. This interpretation allows for a number of details associated with the Pantheon to be rethought within a wider context and alternative proposals advanced regarding the forecourt in front of porch, the “arch” in the centre of this space, the location of the now lost caryatids and bronze columns, the little understood Severan restoration, and the meanings of the much-discussed inscriptions on the façade.
Seeing the Caesar in Germanicus: Reading Tacitus’ Annals with Lucan’s Bellum Civile
Authors: Daly Megan M.
Published: December 2019

The recognition of the similarities between Roman epic poetry and historiography have led to valuable studies such as Joseph’s analysis of the relationship between Lucan’s Bellum Civile and Tacitus’ Histories. Traces of Lucan’s Bellum Civile can also be observed in Tacitus’ Annals 1 and 2, causing the beginning of Tiberius’ reign to look like a civil war in the making. The charismatic Germanicus sits with a supportive army on the northern frontier, much like Caesar, causing fear for Tiberius at Rome. Germanicus denies his chance to become the next Caesar and march on the city, but he exhibits other similarities with Lucan’s Caesar, including an association with Alexander the Great. Although at some points Germanicus seems to be repeating the past and reliving episodes experienced by Caesar in Bellum Civile, he prevents himself from fully realizing a Caesarian fate and becoming Lucan’s bad tyrant. The similar images, events, and themes presented by both authors create messages that reflect experiences from the authors’ own lives during dangerous times.
Machine learning-based prediction of response to growth hormone treatment in Turner syndrome: the LG Growth Study
Authors: Jung Mo Kyung , Yu Jeesuk , Lee Ji-Eun , Kim Se Young , Kim Hae Soon , Yoo Eun-Gyong
Published: December 2019

Background

Growth hormone (GH) treatment has become a common practice in Turner syndrome (TS). However, there are only a few studies on the response to GH treatment in TS. The aim of this study is to predict the responsiveness to GH treatment and to suggest a prediction model of height outcome in TS.

Methods

The clinical parameters of 105 TS patients registered in the LG Growth Study (LGS) were retrospectively reviewed. The prognostic factors for the good responders were identified, and the prediction of height response was investigated by the random forest (RF) method, and also, multiple regression models were applied.

Results

In the RF method, the most important predictive variable for the increment of height standard deviation score (SDS) during the first year of GH treatment was chronologic age (CA) at start of GH treatment. The RF method also showed that the increment of height SDS during the first year was the most important predictor in the increment of height SDS after 3 years of treatment. In a prediction model by multiple regression, younger CA was the significant predictor of height SDS gain during the first year (32.4% of the variability). After 3 years of treatment, mid-parental height (MPH) and the increment of height SDS during the first year were identified as significant predictors (76.6% of the variability).

Conclusions

Both the machine learning approach and the multiple regression model revealed that younger CA at the start of GH treatment was the most important factor related to height response in patients with TS.
The beneficial effect of psychological support on mothers with PKU children who suffer from social discrimination and damage of quality of life
Authors: Iakovou Kostas Konstantinos , Schulpis Kleopatra
Published: December 2019

Background

Phenylketonuria (PKU) is a metabolic disorder of phenylalanine (phe) metabolism caused by the liver enzyme phe hydroxylase deficiency resulting in mental retardation. The only treatment for this disorder is the lifelong restriction of natural protein supplemented with phe-free amino acid formula. The aim of this study was to demonstrate the beneficial effect of psychological support in relation to the educational status on mothers with PKU children, who suffered from social discrimination (SD) and damage of quality of life (QLD).

Methods

A total number of 42 mothers with PKU children with a mean age of 26.8 years took part in this study. According to their educational status, they were divided into three groups: group a, primary school (n = 13); group b, high school (n = 15) and group c, university degree (n = 14). Psychological support was given once per week for 1 year.

Results

University degree mothers achieved the best results in ameliorating their symptoms and signs. Mothers who had completed high school felt a moderate amelioration of their SD and QL, whereas those who had finished primary school only felt a mild reduction of their symptoms. Educational status of the affected mothers should be always taken into account for the classification of the affected mothers into therapeutic groups. Familial and professional environment are very important for the success of psychological support.

Conclusions

Overall, the psychological support related to symptoms and signs of this metabolic disorder is in comparison with that in diabetic patients.
Survey of alongside midwifery-led care in North Rhine-Westfalia, Germany
Authors: Merz Waltraut M. , Heep Andrea , Kandeepan Pirathayini , Tietjen Sophia L. , Kocks Andreas
Published: December 2019

Background

Alongside midwifery-led care (AMC) was introduced in Germany in 2003. The aim of our study was to collect data about the utilization of AMC within North Rhine-Westfalia (NRW), Germany’s most populous state, and to collect information regarding the approach used for implementation of AMC and providers’ experiences in day-to-day work.

Methods

Quantitative data were collected by questionnaire, telephone interview and comparative analysis of documents created for use in AMC. Qualitative data were compiled by questionnaire and workshop.

Results

Seven obstetric departments offer AMC in NRW. On average, 3.4% of women gave birth in these AMC units, corresponding to 0.3% of all births in NRW. For the establishment of AMC, institutional, organizational, professional and formal arrangements were undertaken. An eligibility and transfer checklist was agreed upon between midwives and obstetricians. Both professions were faced with skepticism. Daily work in AMC resulted in improved teamwork between the two professions and increased job satisfaction for midwives. Acquisition of manual skills and time constraints were the major challenges.

Conclusion

The low utilization of AMC is not due to the concept of care itself or difficulties with its implementation, nor to a lack of eligible women. Reasons may be insufficient awareness about AMC or a lack of interest in this type of care.
Correlation between aneuploidy pregnancy and the concentration of various hormones and vascular endothelial factor in follicular fluid as well as the number of acquired oocytes
Authors: Liang Lin , Zhao Xiao-Xi
Published: December 2019

Objective

To investigate the correlation between aneuploidy pregnancy and the concentration of various hormones and vascular endothelial factor in follicular fluid as well as the number of acquired oocytes and to provide a scientific basis for improving ovulation induction programs.

Methods

In total, we collected 277 follicular fluid specimens from patients undergoing in vitro fertilization (IVF) treatment in our hospital. Eighteen cases of aneuploidy embryos were identified. The follicular fluid of these aneuploidy embryos was used for the study. According to the case and control 1:5 paired design, we selected five age-matched controls with healthy births following IVF for each aneuploidy case. Concentrations of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2) and vascular endothelial growth factor (VEGF) in the follicular fluid were measured. Conditional logistic regression was used to analyze the relationship between aneuploidy pregnancy and the concentrations of various hormones and VEGF in the follicular fluid as well as the number of acquired oocytes.

Results

Multivariate conditional logistic regression showed that of all the factors analyzed, only FSH [odds ratio (OR) = 1.300, 95% confidence interval (CI), 1.091–1.548, P = 0.003] level in the follicular fluid and the number of acquired oocytes (OR = 1.179, 95% CI, 1.070–1.299, P = 0.001) were closely related to aneuploidy pregnancy. No other factors were found to be associated with aneuploidy pregnancy.

Conclusion

FSH concentrations in the follicular fluid are risk factors for aneuploidy pregnancies. The higher the number of eggs, the higher the risk of aneuploidy. These findings may help improve ovulation induction programs.
Route identification in the National Football League
Authors: Chu Dani , Reyers Matthew , Thomson James , Wu Lucas Yifan
Published: December 2019

Tracking data in the National Football League (NFL) is a sequence of spatial-temporal measurements that varies in length depending on the duration of the play. In this paper, we demonstrate how model-based curve clustering of observed player trajectories can be used to identify the routes run by eligible receivers on offensive passing plays. We use a Bernstein polynomial basis function to represent cluster centers, and the Expectation Maximization algorithm to learn the route labels for each of the 33,967 routes run on the 6963 passing plays in the data set. With few assumptions and no pre-existing labels, we are able to closely recreate the standard route tree from our algorithm. We go on to suggest ideas for new potential receiver metrics that account for receiver deployment and movement common throughout the league. The resulting route labels can also be paired with film to enable streamlined queries of game film.
Discovery of a new genus record for Paraguay, the Atlantic Forest endemic rodent Abrawayaomys (Cricetidae, Sigmodontinae)
Authors: de la Sancha Noé U. , Libardi Gustavo S. , Pardiñas Ulyses F.J.
Published: December 2019

The mammals of Paraguay are still poorly known. We report a new genus for the country, Abrawayaomys, a spiny cricetid rodent endemic for the Interior Atlantic Forest. This record extends the distribution of the genus approximately 100 km, and west of the Paraná River. This addition increases the number of mammals in Paraguay to 184 and verifies that rodents are the most diverse group of mammals in the country. We outline identifying morphological characters of Abrawayaomys and elaborate on the significance of this finding for conservation and biogeography in the region.