bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of aluminum concentration on growth and secondary metabolites production in three chemotypes of Cunila galioides Benth. medicinal plant
Authors: Mossi AJ. , Pauletti GF. , Rota L. , Echeverrigaray S. , Barros IBI. , Oliveira JV. , Paroul N. , Cansian RL.
Published: February 2015

Medicine plants play an important role in public health, especially in developing countries, and among them Cunila galioides Benth. is a naturally occurring medicinal and aromatic plant native from south Brazil. Flavonoids, present in significant amounts in some species of Cunila sp., possess several properties and its content may be affected by aluminum stress. In this context, the aim of this work was to assess the influence of different levels of aluminum in nutrient solution on the growth and content of essential oils and flavonoids in three chemotypes of Cunila galioides. The plant parameters evaluated were aerial dry matter, dry root matter, root length, root score, calcium and aluminum concentrations in the vegetable tissue, flavonoids content as well as essential oil yield and its major components concentration. Results showed that the addition of 30.0 mg.L--1 of Al3+ to the nutrient solution leads to a decrease of all agronomic parameters evaluated with losses in the cultivation yield for the greatest concentration studied. The André da Rocha population was found to be the most tolerant to aluminum while Bom Jardim da Serra was the most sensitive. The aluminum concentration did not influence the extraction yield as well as the content of major components in the oils. The concentration of flavonoids increased significantly for the populations tolerant to aluminum concentration in the nutrient solution, thus indicating a relationship between tolerance and flavonoids production, which may be an interesting characteristic from the medicinal point of view.
An interactive tutorial of molecular modelling
Authors: Silveira C. H. , Jacchieri S.
Published: February 2015

Abstract of the panel presented at the event ( attached) .
Relationship between sponsor and students
Authors: Fonseca et al. L.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attached).
Software: oxygen consumption by isolated mitochondria
Authors: Kubo R. T. , Galembeck E. , Macedo D. V. , Torres Bayardo Baptista
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see the attachment).
Metabolism and problem based learning an integrated proposal of basic and clinical sciences
Authors: Vargas L. H.M. , Ribeiro M. L.L.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see Attachment).
Nutriton - An interactive approach to food metabolism
Authors: Yokaichiya D. K. , Torres Bayardo Baptista , Galembeck Eduardo
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see Attachment).
A laboratory exercise illustrating metabolic regulation: induction, repression and inactivation of a yeast sugar transporter
Authors: Stambuk B. U.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
Learning Biochemistry by teaching
Authors: Sakabe N. J.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
High school Biochemistry under the chemical spotligth
Authors: Marson G. A. , Nóbrega O. S.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
The role of Biochemistry on Pharmacy postgraduation program at Federal University of Santa Catarina (PPGFAR/ UFSC)
Authors: Falkenberg M. , Machado M. J.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
A new educational software on ion exchange chromatograph technique
Authors: Marson G. A. , Torres Bayardo Baptista
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
The protein folder: a kit for building topological models of proteins: an evaluation
Authors: Santos et al. N. F.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
The transfer of Molecular Biology and Genetic engineerings knowlodge to high school: problems and solutions
Authors: Ometto-Nascimento T. A. , Turcinelli E. R. , De Meis L. , Lannes D. , Arruda P.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
Biochemistry teaching by using theater play as a pedagogical tool
Authors: Almeida et al. M. R.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
Internet distance educacion courses: how can it be?
Authors: Yokaichiya D. K. , Galembeck E. , Torres Bayardo Baptista
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
The Brazilian Genetic human resources scientific productivity and graduation
Authors: Turcinelli S. R. , Arruda P.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
Molecular game: an easy way to learn DNA cloning
Authors: Silva-Silva et al. A. M.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
A software introducing plant photosynthesis
Authors: Silveira R. V.M. , Torres Bayardo Baptista
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament)
A practical exercise in Digestive P\Physiology for Biology students
Authors: Jordão Beatriz Pacheco
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
Acetylcholinesterase response to salts in teaching the validation of toxicity bioindicatiors
Authors: Silva Filho M. V. , Bastos J. Cunha , Faria M. V. Csatro
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
Insulin-Leptin game: a new approach to teach hormonal signalling
Authors: Araujo D. R. , Silva J. A. , Galembeck E.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
Teaching Biochemistry in the pharmacy course using clinical cases
Authors: Miyagui et al. D. T.
Published: February 2015

Abstract of the panel presented at the SBBq annual meeting (see attachament).
Karyotype Learning Center: A Software For Teaching And Learning Cytogenetics
Authors: De Mesquita Joelma Freire , Dos Santos Suely R. , Paiva Carmen Lucia A.
Published: February 2015

The in vitro cultivation of human cells is an essential part of the work of every diagnostic cytoge-netics laboratory. Almost all human cytogenetic studies involve the examination of dividing bloodcell population by blocking cell division at metaphase with subsequent processing and staining bybanding techniques. The chromosome constitution is described as Karyotype that states the totalnumber of chromosomes and the sex chromosome constitution. Karyotypes are prepared by cuttingup a photograph of the spread metaphase chromosomes, matching up homologous chromosomes andsticking them back down on a card or nowadays more often by getting an image analysis computerto do the job. Chromosomes are identied by their size, centromere position and banding pattern.Teaching a student how to detect and interpret even the most common chromosome abnormaliti-es is a major challenge: mainly, in a developing country where the laboratorial facilities are notalways available for a big number of students. Therefore, in this work we present an educationalsoftware for teaching undergraduate students of Medical and Life Sciences Courses how to arrangenormal and abnormal chromosomes in the form of karyotype. The user, using drag-and-drop, is da-red to match up homologous chromosome. For that, we have developed a free full access web site(http://www.biomol.net/cariotipo/) for hosting the software. The latter has proved to be light andfast even under slow dial-up connections. This web site also oers a theoretical introductory sectionwith basic concepts about karyotype. Up to now the software has been successfully applied to un-dergraduate courses at the University of Rio de Janeiro (UNIRIO). The students have approved thesoftware; to them the similarities with the well-known game solitaire turns the exercise more excitingand provides additional stimulus to learn and understand karyotype. Professors have also used thesoftware as complementary material in their regular classes. Based on their testimonies the softwarewas a helpful tool for explaining the karyotype assembly.
BUILDING THE LIFE MOLECULES: DNA AND RNA
Authors: Beltramini L.M. , De Ara A.P.U. , Abel L.D.S. , Carvalho J.C.Q. , Ramos O.H.P. , Oliveira T.H.G. , Moron F. , Dos Santos N.F.
Published: February 2015

The dissemination area of the Centro de Biotecnologia Molecular Estrutural (CBME) have beendeveloping a program of new tools to help teaching and learning of structural molecular biology areaat all levels, from elementary to graduate schools. In this way, we have developed a kit denotedBuilding the life molecules: DNA and RNA. The kit is composed by: (1) an interactive software calledThe Virtual Cells, used to facilitate the comprehension of the structures and functions of dierent typesof cells; (2) several small plastic elements with proper exibility that allows building DNA and RNAstructure models; (3)an Amino Acid Disk, with the amino acids structures, their abbreviation and thegenetic code; (4) a folder containing a historical about events on DNA discovery and instruction toused the tools. These tools contribute to the understanding of the cell structure, its dierent organellesand functions, specially the organization of the nucleus, nucleic acids and genetic code. The plasticelements and Amino Acid Disk permit the students to understand DNA and RNA molecule structure,as well as the semi conservative duplication of DNA, the transcription and translation processes.Such plastic components emphasize chemical connections and respect the real molecular structureparameters keeping size proportionality. The Amino Acid Disk is composed by superposed rotatingdisks, with openings allowing information on the amino acids can be observed. In the opposite facecontents a genetic code table. With this tool, teachers and students are able to simulate the synthesisof a given protein, after assembling the structure of RNAm and perceiving the molecular dynamic.The historical about events on DNA discovery helps one to better understand the development ofscience. We have evaluated this kit and its usefulness in learning. The data demonstrated it has highdidactic potential since of its easy handling. The development of this kit is part of a broad diusionproject of scientic knowledge, which CBME performs with the purpose of providing, in a playful way,the comprehension of the structure-function paradigm of biological macromolecules.
A biochemistry discipline designed for the nutrition course
Authors: Bianco A.A.G. , Torres B.B.
Published: February 2015

Biochemistry is widely considered an essential background in a Nutrition Course framework. At theFaculdade de Saude Publica, USP, it is a direct requirement to eight disciplines of the syllabus and anindirect requirement to another nine disciplines. Nevertheless, a previous interview study involvingNutrition students and Nutritionists revealed a contradictory image of Biochemistry. Although stu-dents and Nutritionists admitted the important role played by Biochemistry, most of the respondentsdeclared that they could not foresee any application of Biochemical contents in their professional life.Aiming to change this situation, a deep intervention in the Biochemistry discipline was carried on.The discipline was planned in such a way that all the contents to be taught was directly derived fromsubjects or situations matching the interests of nutrition students. Instead of a classical lecture basedcourse, collaborative learning was the methodological choice, taking advantage of practical activitiesinvolving educational software and laboratory work as well. The course was carried on in 180 hoursand a variety of strategies were employed, especially small group discussion and problem solving. Thestudents were given a booklet containing all the exercises and problems, which acted as course guide.At the end of the course, an evaluation survey was carried out. It is noticeable that, according tostudents answers: 100% agreed that Biochemistry was intimately linked to Nutrition; 83% appreciatedthe didactical methodologies employed; 89% would like to continue studying Biochemistry in a furtherdiscipline; 96% declared that the discipline has raised their interest in Biochemistry. In respect tothe assessment of the students, these results are in accordance with the opinion of teachers and TAsengaged in restructuring Biochemistry courses.
Beyond desertification: new paradigms for dryland landscapes
Authors: Peters Debra PC , Havstad Kris M , Archer Steven R , Sala Osvaldo E
Published: February 2015

The traditional desertification paradigm focuses on the losses of ecosystem services that typically occur when grasslands transition to systems dominated by bare (unvegetated) ground or by woody plants that are unpalatable to domestic livestock. However, recent studies reveal complex transitions across a range of environmental conditions and socioeconomic contexts. The papers in this Special Issue illustrate how an improved understanding of these dynamics is generating more robust paradigms, where state changes and regime shifts occurring within the context of changes in land use and climate are modified by landform and antecedent conditions. New and emerging technologies are being used to characterize and evaluate processes and outcomes across various scales and levels of organization. At the same time, developments in education are taking advantage of these new perspectives to improve the ecological literacy of future generations, and to better inform land‐management decisions. A framework that integrates these perspectives provides a more comprehensive approach for understanding and predicting dryland dynamics.
Patterns of Aggressive Behaviour and Victimization in Adolescents
Authors: Farnicka Marzanna , Grzegorzewska Iwona
Published: February 2015

The objective of the presented research was to find the family determinants for undertaking the aggressor or victim role. The obtained results enabled the description of environmental (family-related) and developmental factors that have a bearing on the formation of perpetrator or victim identity. For that purpose, two groups of variables were identified. The first group included child-independent variables shaping the socio-economic status of the family (parents’ education, material status, number of siblings), while the second group pertained to the patterns of attachment to each parent. The sample consisted of 120 adolescents aged 13 to 20. The research tools were Mini – DIA, the Inventory of Parent and Peer Attachment – IPPA, and Buss-Perry aggression questionnaire. The results revealed a number of determinants for persons involved in perpetration or victimization, such as the type of relationship with parents (secure or insecure pattern), personal experience of being in the victim or aggressor role, and the level of hostility. The resulting “determinant bundles” may inform professionals in their work with adolescents in the field of prevention or therapy.
Domestic Consequences of US Counter-Terrorism Efforts: Making it Harder to Prevent Homegrown Terrorism
Authors: LoCicero Alice
Published: February 2015

This paper begins by recounting concerns, raised by various American psychologists regarding psychological consequences of US counterterrorism policies following the attacks of September 11, 2001 (9/11.) Predictions made by a task force created by the American Psychological Association to consider the likely social effects of US counterterrorism policies have proved accurate. These include not only fear, but widespread crippling panic resulting from vague warnings and lack of suggested actions; discrimination, resulting from increased emphasis on in-group vs. out-group identities; hate crimes against those perceived as members of out-groups, and lack of tolerance for antiwar perspectives. Recent, increasingly radical, changes in policy, such as widespread surveillance of US citizens’ actions and communications by various US agencies, have led to more dire consequences, with many now concerned that the US is at risk of becoming a police state. The combined and interactive effects of earlier and more recent changes in US counterterrorism policies have caused serious, sometimes terrible, consequences. This paper explains how these consequences have become part of a vicious circle: frightened, passive, and unable to collaborate in rational attempts to manage the threat of terrorism, citizens have not begun to consider how to prevent future instances of homegrown terrorism.
Performance evaluation of Kogi State Agricultural Development Programme since the withdrawal of World Bank’s assistance to Nigeria
Authors: Agbamu Joseph
Published: February 2015

This study evaluated the performance of Kogi State Agricultural Development
Programme (KADP) during World Bank?s assistance period (1991 to 1995) and
after World Bank?s assistance period (2009 to 2013). Data were collected
through the use of questionnaire and interviews of 120 farmers and 60 staff
members of KADP and through various secondary sources of information. It was
found that during World Bank?s assistance, KADP received N2.25 billion, while
it received N928.9 million after cessation of the assistance. From 1991 to
1995, KADP received 72.6% of its funding from the World Bank and
International Fund for Agricultural Development. From 2009 to 2013, KADP
received 83.1% of its funding from international organizations. KADP had a
high degree of dependency on temporary international assistance. Analysis of
19 performance indicators showed that a significant difference exists in
KADP?s performance between before and after World Bank?s assistance, with
better performance during the period of World Bank?s assistance, 1991?1995.
This study discussed the effects of World Bank?s withdrawal and the measures
taken by KADP to strengthen itself.
Synthesis of modified pyridine and bipyridine substituted coumarins as potent antimicrobial agents
Authors: Lad Hemali , Giri Rakesh , Chovatiya Yogita , Brahmbhatt Dinkar
Published: February 2015

In search for new antimicrobial agents a series of new modified pyridine and
bipyridine substituted coumarins 5a-y was designed and synthesized by
adopting molecular hybridization strategy. All the synthesized compounds were
evaluated for their in vitro antimicrobial activity using broth dilution
method against selected bacterial (Gram-positive and Gram-negative) and
fungal strains. Compounds 5a, 5f, 5g, 5n, 5r, 5t, 5w, 5x and 5y demonstrated
promising antibacterial activity while other derivatives showed comparable
activity to standard drugs used as reference.
Non-chromatographic methods focused on speciation of arsenic and selenium in food and environmental samples
Authors: Rezende Helen C. , Almeida Ione L. S. , Coelho Luciana M. , Coelho Nívia M. M. , Marques Thiago L.
Published: February 2015

Speciation is a promising and essential tool in the evaluation of the contamination of metals in food and environmental samples. In this context, information about the species of these elements is important considering that toxic effects are directly related to their chemical forms. The enormous progress in combining separation and detection techniques has enabled the effective chemical speciation. However, a possible source of error in studies of speciation occurs during sample preparation. Appropriate treatment of samples is necessary in order to ensure that interconversion between the species does not occur during the experimental procedure prior to the final analysis. In this review, methods of sample preparation for the determination of arsenic and selenium in food and environmental samples are discussed. We decided to focus on these elements since they account for around 50% of all speciation studies. Procedures including conventional extraction, microwave-assisted extraction and sonolysis are discussed as simple ways to ensure species selectivity. The main purpose of this review is to provide an update on the recent literature concerning the strategies for arsenic and selenium speciation and to critically discuss their advantages and weaknesses compared with the commonly accepted approach of combining non-chromatographic and spectroscopic techniques. The problems focused on involve sampling, sample preparation and storage, as well as changes in ‘species information’ that occur during the use of various separation technologies. These difficulties are described along with recent developments aimed at overcoming these potential issues.
Speckle reduction in double-pass retinal images using variable-focus lenses
Authors: García-Guerra C. E. , Aldaba M. , Arjona M. , Pujol J.
Published: February 2015

Speckle arises in double-pass images when coherent light is scattered by the retina. Since this noise degrades the images that are used to characterize the eye, there is special attention in reducing speckle when working with instruments based on retina reflections. In this work, we present a method for speckle reduction in double-pass retinal images by producing minor periodic variations in the vergence of the beam entering the eye with a variable-focus lens during image recording. Measurements in an artificial and a real eye following the implementation of the method corroborate the speckle reduction.
A Process-Based Approach to Estimate Chinese Fir (Cunninghamia lanceolata) Distribution and Productivity in Southern China under Climate Change
Authors: Lu Yuhao , Coops Nicholas , Wang Tongli , Wang Guangyu
Published: February 2015

Understanding the distribution and productivity of Chinese fir (Cunninghamia lanceolata) under climate change is critical given the ecological and economic importance of the species. Recently, process-based growth models have grown in their popularity given their simplicity and data availability, and they are increasingly being used to map the distribution and productivity of tree species. In this paper, we study the extent of variation of the current range shift and the productivity of the species under a changing climate. We used the Physiological Principles in Predicting Growth (3-PG) model, which calculates the extent to which climatic variables affect photosynthesis and growth of a species. These variables were then used in a decision-tree model to develop rules to provide a basis for predicting the distribution of the species under current climatic conditions. Once the distribution model was developed the productivity of the species was then assessed. Using climate projections we then simulated the growth and distribution into the future. Results indicate a northward shift from the current range. The growth model also indicates minor increases in productivity in some of the existing distribution areas, principally in central China with limited productivity predicted in newly emerged stands. We conclude that this dual modeling approach has potential to quantify impacts of climate change on selected species and examining differences in climate projections on range and productivity estimation.
Thermodynamic Relations for the Entropy and Temperature of Multi-Horizon Black Holes
Authors: Xu Wei , Wang Jia , Meng Xin-he
Published: February 2015

We present some entropy and temperature relations of multi-horizons, even including the “virtual” horizon. These relations are related to the product, division and sum of the entropy and temperature of multi-horizons. We obtain the additional thermodynamic relations of both static and rotating black holes in three- and four-dimensional (A)dS spacetime. Especially, a new dimensionless, charge-independence and T+S+ = T_S_-like relation is presented. This relation does not depend on the mass, electric charge, angular momentum and cosmological constant, as it is always a constant. These relations lead us to obtaining some interesting thermodynamic bounds of entropy and temperature, including the Penrose inequality, which is the first geometrical inequality of black holes. Besides, based on these new relations, one can obtain the first law of thermodynamics and the Smarr relation for all horizons of a black hole.
Assessment of Spatial Interpolation Methods to Map the Bathymetry of an Amazonian Hydroelectric Reservoir to Aid in Decision Making for Water Management
Authors: Curtarelli Marcelo , Leão Joaquim , Ogashawara Igor , Lorenzzetti João , Stech José
Published: February 2015

The generation of reliable information for improving the understanding of hydroelectric reservoir dynamics is fundamental for guiding decision-makers to implement best management practices. In this way, we assessed the performance of different interpolation algorithms to map the bathymetry of the Tucuruí hydroelectric reservoir, located in the Brazilian Amazon, as an aid to manage and operate Amazonian reservoirs. We evaluated three different deterministic and one geostatistical algorithms. The performance of the algorithms was assessed through cross-validation and Monte Carlo Simulation. Finally, operational information was derived from the bathymetric grid with the best performance. The results showed that all interpolation methods were able to map important bathymetric features. The best performance was obtained with the geostatistical method (RMSE = 0.92 m). The information derived from the bathymetric map (e.g., the level-area and level-volume diagram and the three-dimensional grid) will allow for optimization of operational monitoring of the Tucuruí hydroelectric reservoir as well as the development of three-dimensional modeling studies.
A New Ni-Based Metallic Glass with High Thermal Stability and Hardness
Authors: Hitit Aytekin , Şahin Hakan , Öztürk Pelin , Aşgın Ahmet
Published: February 2015

Glass forming ability (GFA), thermal stability and microhardness of Ni51−xCuxW31.6B17.4 (x = 0, 5) metallic glasses have been investigated. For each alloy, thin sheets of samples having thickness of 20 µm and 100 µm were synthesized by piston and anvil method in a vacuum arc furnace. Also, 400 µm thick samples of the alloys were synthesized by suction casting method. The samples were investigated by X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). Crystallization temperature of the base alloy, Ni51W31.6B17.4, is found to be 996 K and 5 at.% copper substitution for nickel increases the crystallization temperature to 1063 K, which is the highest value reported for Ni-based metallic glasses up to the present. In addition, critical casting thickness of alloy Ni51W31.6B17.4 is 100 µm and copper substitution does not have any effect on critical casting thickness of the alloys. Also, microhardness of the alloys are found to be around 1200 Hv, which is one of the highest microhardness values reported for a Ni-based metallic glass until now.
Carrier multiplication in silicon nanocrystals: ab initio results
Authors: Marri Ivan , Govoni Marco , Ossicini Stefano
Published: February 2015

One of the most important goals in the field of renewable energy is the development of original solar cell schemes employing new materials to overcome the performance limitations of traditional solar cell devices. Among such innovative materials, nanostructures have emerged as an important class of materials that can be used to realize efficient photovoltaic devices. When these systems are implemented into solar cells, new effects can be exploited to maximize the harvest of solar radiation and to minimize the loss factors. In this context, carrier multiplication seems one promising way to minimize the effects induced by thermalization loss processes thereby significantly increasing the solar cell power conversion. In this work we analyze and quantify different types of carrier multiplication decay dynamics by analyzing systems of isolated and coupled silicon nanocrystals. The effects on carrier multiplication dynamics by energy and charge transfer processes are also discussed.
Antivirals against Enteroviruses: A Critical Review from a Public-Health Perspective
Authors: Benschop Kimberley SM , Van Der Avoort Harrie GAM , Duizer Erwin , Koopmans Marion PG
Published: February 2015

The enteroviruses (EVs) of the Picornaviridae family are the most common viral pathogens known. Most EV infections are mild and self-limiting but manifestations can be severe in children and immunodeficient individuals. Antiviral development is actively pursued to benefit these high-risk patients and, given the alarming problem of antimicrobial drug resistance, antiviral drug resistance is a public-health concern. Picornavirus antivirals can be used off-label or as part of outbreak control measures. They may be used in the final stages of poliovirus eradication and to mitigate EV-A71 outbreaks. We review the potential emergence of drug-resistant strains and their impact on EV transmission and endemic circulation. We include non-picornavirus antivirals that inhibit EV replication, for example, ribavirin, a treatment for infection with HCV, and amantadine, a treatment for influenza A. They may have spurred resistance emergence in HCV or influenza A patients who are unknowingly coinfected with EV. The public-health challenge is always to find a balance between individual benefit and the long-term health of the larger population.
Abatacept in the Treatment of Severe, Longstanding, and Refractory Uveitis Associated with Juvenile Idiopathic Arthritis
Authors: Tappeiner Christoph , Miserocchi Elisabetta , Bodaghi Bahram , Kotaniemi Kaisu , Mackensen Friederike , Gerloni Valeria , Quartier Pierre , Lutz Thomas , Heiligenhaus Arnd
Published: February 2015

Objective.

Abatacept (ABA), a selective T cell costimulation modulator that binds to CD80 and CD86 on antigen-presenting cells, was investigated for its antiinflammatory effect in treating severe chronic uveitis associated with juvenile idiopathic arthritis (JIA).

Methods.

Our retrospective study was conducted by members of the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC). Patients with JIA who are receiving ABA treatment for active uveitis were included. In all patients, uveitis had been refractory to previous topical and systemic corticosteroids, immunosuppressives, and at least 1 tumor necrosis factor–α inhibitor. A standardized protocol was used to document uveitis (MIWGUC) and arthritis. Baseline visit and visits at 3, 6, 9, and 12 months before and after ABA start were evaluated. Primary outcome measure was defined as achievement of uveitis inactivity; secondary outcome measures were tapering of corticosteroid and/or immunosuppressive treatment, and occurrence of complications.

Results.

In all, 21 patients (16 female) with active uveitis (n = 21) and arthritis (n = 18) were included (mean age 11.8 ± 3.6 yrs). In 7 of 18 patients with active arthritis at baseline, inactivity was achieved following ABA treatment. Uveitis inactivity was achieved in 11 patients, but recurred later in 8 of them, and remained active in another 10 cases. Systemic corticosteroids or immunosuppression were tapered in 3 patients, but uveitis recurred in all of them during further followup. Ocular complications secondary to uveitis were present in 17 patients at baseline, while 3 patients developed new ocular complications during followup.

Conclusion.

A sustained response to ABA was uncommon in patients with severe and refractory uveitis.
Assessment of Risks of Pulmonary Infection During 12 Months Following Immunosuppressive Treatment for Active Connective Tissue Diseases: A Large-scale Prospective Cohort Study
Authors: Yamazaki Hayato , Sakai Ryoko , Koike Ryuji , Miyazaki Yasunari , Tanaka Michi , Nanki Toshihiro , Watanabe Kaori , Yasuda Shinsuke , Kurita Takashi , Kaneko Yuko , Tanaka Yoshiya , Nishioka Yasuhiko , Takasaki Yoshinari , Nagasaka Kenji , Nagasawa Hayato , Tohma Shigeto , Dohi Makoto , Sugihara Takahiko , Sugiyama Haruhito , Kawaguchi Yasushi , Inase Naohiko , Ochi Sae , Hagiyama Hiroyuki , Kohsaka Hitoshi , Miyasaka Nobuyuki , Harigai Masayoshi
Published: February 2015

Objective.

Pulmonary infections (PI) are leading causes of death in patients with connective tissue diseases (CTD). The PREVENT study (Pulmonary infections in patients REceiving immunosuppressiVE treatmeNT for CTD) assessed risk of PI in patients with active CTD in the contemporary era of advanced immunosuppressive therapy.

Methods.

In patients who started corticosteroids (n = 763), conventional immunosuppressants or biologics for active CTD were enrolled. Clinical and laboratory data, usage of drugs, and occurrence of PI were collected for 12 months. Baseline risk factors were investigated using Cox regression analysis. A nested case-control (NCC) study was performed with 1:2 matched case-control pairs to assess the risk for each drug category.

Results.

During the observation period, 32 patients died (4.2%) and 66 patients were lost to followup (8.6%). Patients with PI (n = 61, 8%) had a significantly worse accumulated survival rate than patients without (p < 0.01). Cox hazard regression analysis using baseline data showed that these factors were significantly associated with PI: age ≥ 65 years (HR 3.87, 95% CI 2.22–6.74), ≥ 20 pack-years of smoking (2.63, 1.37–5.04), higher serum creatinine level (1.21, 1.05–1.41 per 1.0 mg/dl increase), and maximum prednisolone (PSL) dose during the first 2 weeks of treatment (2.81, 1.35–5.86 per 1.0 mg/kg/day increase). Logistic regression analysis by an NCC study revealed that maximum PSL dose within 14 days before PI (OR 4.82, 95% CI 1.36–17.01 per 1.0 mg/dl increase; 2.57, 1.28–5.16 if ≥ 0.5 mg/kg/day) was significantly associated with the events, while other immunosuppressants were not.

Conclusion.

Physicians should be aware of the higher risks for corticosteroids of PI than other immunosuppressants and assess these risk factors before immunosuppressive treatment, to prevent PI.
Imaging as an Outcome Measure in Gout Studies: Report from the OMERACT Gout Working Group
Authors: Grainger Rebecca , Dalbeth Nicola , Keen Helen , Durcan Laura , Lawrence Edwards N. , Perez-Ruiz Fernando , Diaz-Torne Cesar , Singh Jasvinder A. , Khanna Dinesh , Simon Lee S. , Taylor William J.
Published: February 2015

Objective.

The gout working group at the Outcome Measures in Rheumatology (OMERACT) 12 meeting in 2014 aimed to determine which imaging modalities show the most promise for use as measurement instruments for outcomes in studies of people with chronic gout and to identify the key foci for future research about the performance of these imaging techniques with respect to the OMERACT filter 2.0.

Methods.

During the gout session, a systematic literature review of the data addressing imaging modalities including plain radiography (XR), conventional computed tomography (CT), dual-energy computed tomography (DECT), magnetic resonance imaging (MRI), and ultrasound (US) and the fulfillment of the OMERACT filter 2.0 was presented.

Results.

The working group identified 3 relevant domains for imaging in gout studies: urate deposition (tophus burden), joint inflammation, and structural joint damage.

Conclusion.

The working group prioritized gaps in the data and identified a research agenda.
Bill of Services (BOS)
Authors: Vitner Gad
Published: February 2015

Bill of Services (BOS) is a novel management tool designed to support service organizations in developing their services and planning resources to satisfy management's target service level. This paper presents a methodology for configuration of the BOS in a manner similar to configuration of the Bill of Materials (BOM) in a manufacturing organization. Definition of the BOS enables management to calculate the capacity of the resources needed to satisfy service demand and support the cost process of any service category in the organization. The BOS may also support management during the phase of negotiations with potential customers by testing various service alternatives. The BOS assists management in the day-to-day planning and control of activities, and facilitates a professional management infrastructure in service organizations. The paper presents a detailed example of a hotel BOS and elaborates the advantages of using this management tool.
Socio-Economic Correlates of Information Security Threats and Controls in Global Financial Services Industry
Authors: Ifinedo Princely
Published: February 2015

Threats to data and information assets of Global Financial Services Industry (GFSI) are ever-present; such problems, if not well understood, could lead to huge negative impact. To some extent, the environment where a business operates does matter for its success. This study presents information about the relationships between selected socio-economic factors and information security threats and controls in the financial services industry. Essentially, it seeks to enrich the information provided in the 2012 Deloitte Touche Tohmatsu Limited (DTTL) survey that dealt with about security threats in the industry. This study's findings indicated that contextual factors, such as national wealth, transparency levels, staff training, tertiary education enrolment, and buyer sophistication, do have positive associations with some information security threats and controls. Practitioners and academicians can benefit from this study's insights.
Bronchobiliary Fistula Localized by Cholescintigraphy with Single-Photon Emission Computed Tomography
Authors: Artunduaga Maddy , Patel Niraj , Wendt Julie , Guy Elizabeth , Nachiappan Arun
Published: February 2015

Biliptysis is an important clinical feature to recognize as it is associated with bronchobiliary fistula, a rare entity. Bronchobiliary fistulas have been diagnosed with planar cholescintigraphy. However, cholescintigraphy with single-photon emission computed tomography (SPECT) can better spatially localize a bronchobiliary fistula as compared to planar cholescintigraphy alone, and is useful for preoperative planning if surgical treatment is required. Here, we present the case of a 23-year-old male who developed a bronchobiliary fistula in the setting of posttraumatic and postsurgical infection, which was diagnosed and localized by cholescintigraphy with SPECT.
Od najpomembnejših k najbolj ilustrativnim avtorjem: Théophile Gautier kot izhodišče za pouk o francoski romantični književnosti
Authors: Marinčič Katarina
Published: February 2015

Članek naniza nekaj predlogov za poučevanje književnosti in literarne zgodovine v obdobju interneta. Opozarja na dejstvo, da v dobi, ko primarni in sekundarni viri postajajo iz dneva v dan dostopnejši, učitelj v veliki meri izgublja vlogo posredovalca gradiv in osnovnih podatkov. Po drugi strani pa ga obilica informacij postavlja pred novo nalogo: učencu oziroma študentu mora pomagati pri časovni orientaciji in iskanju bistvenega. V tem kontekstu se zdi smiselno, da poleg avtorjev, ki sodijo v literarni kanon, pri pouku literarne zgodovine obravnavamo tudi (relativno) manj pomembne, a ilustrativne avtorje (kot primer iz francoske literarne zgodovine navajamo Théophila Gautiera).
Močne implementacije metode CLIL v osnovnih šolah v Sloveniji in na Škotskem z učiteljskega vidika
Authors: Ule Katarina
Published: February 2015

Članek povzema bistvene točke metodologije CLIL z namenom, da se ugotovi možne implementacije CLIL-a v slovenskih in škotskih osnovnih šolah z učiteljskega vidika. Pri tej metodi gre za vsebinsko usmerjen pristop k učenju tujih jezikov. Obe državi, Slovenija in Škotska, sta si pri izvajanju te metodologije podobni, čeprav je njun odnos do učenja tujih jezikov drugače pogojen, saj je slovenščina na svetovni lestvici eden izmed manjših jezikov, medtem ko je angleščina najbolj razširjen svetovni jezik. Za boljše razumevanje možnosti izvajanja CLIL-a je obdelan tudi slovenski in škotski učni načrt za poučevanje modernih tujih jezikov. Na koncu pa so predstavljeni še rezultati, pridobljeni z anketo, narejeno med slovenskimi in škotskimi učiteljicami o njihovem odnosu in mnenju o CLIL-u.
Med fonemsko, glasovno in grafično učno zmožnostjo
Authors: Vitez Primož
Published: February 2015

V jedru usvajanja materinščine je dejstvo, da je usvojitveni jezikovni material akustičen, se pravi govor. Zvoka in zvena materinščine je otrok deležen že v prednatalnih razvojnih fazah, tako da po rojstvu v mimetičnih procesih samo še izostruje in z izkušnjami nadgrajuje že zasnovano jezikovno zmožnost in občutljivost. Nasprotno je izhodiščni material pri šolskem usvajanju tujega jezika praviloma pisne narave, zato govorne vsebine pouka tujega jezika pogosto izhajajo iz pisnih predlog in so velikokrat reducirane na ta odnos. Govor je v tujem jeziku praviloma nadgradnja predvsem branja, pozneje tudi pisanja. Takšno razmerje med pisavo in govorom je pogojeno z naravo tujejezičnega učnega procesa, v katerem je pisava, podobno kot sam učni postopek, nujno favorizirana kot intelektualno središče pridobivanja jezikovne kompetence.
Neformalno učenje tujih jezikov v Sloveniji – posnetek iz zraka
Authors: Sešek Urška
Published: February 2015

Članek podaja osnovni pregled neformalnega učenja tujih jezikov v Sloveniji, saj je do sedaj objavljenih le malo virov s podatki o tej tematiki, čeprav bi bili pri odločanju o tujejezikovnem izobraževanju in jezikovni politiki vsekakor koristni. Pregled ločeno obravnava tri starostne skupine: predšolske otroke, šolsko mladino ter odrasle. Obseg in oblike neformalnega učenja tujih jezikov kot tudi nabor najpogostejših jezikov se med temi skupinami nekoliko razlikujejo. Prispevek črpa iz razpoložljivih podatkov, ki niso enako celostni in zanesljivi kot podatki o formalnem učenju tujih jezikov, vendar nakazujejo nekaj razmisleka vrednih trendov, na primer velik porast učenja tujih jezikov v predšolski in osnovnošolski dobi ter rastoče povpraševanje po nekaterih jezikih, ki so v formalnem izobraževanju zelo redko zastopani.
Stališča staršev na Notranjskem in poglavitni motivacijski dejavniki za vključitev otrok v programe zgodnjega učenja tujega jezika pred otrokovim devetim letom starosti
Authors: Premrl Darja
Published: February 2015

V prispevku predstavljamo stališča staršev na Notranjskem o sodobnih izhodiščih na področju zgodnjega učenja in poučevanja tujih jezikov in njihov vpliv na odločanje staršev za (ne)vključitev otrok v programe zgodnje poučevanje tujega jezika. Na eni strani ­ugotavljamo slabo seznanjenost staršev s strokovno literaturo in slabo poznavanje aktualnega stanja v Sloveniji in v tujini na področju zgodnjega poučevanja tujih jezikov. Na drugi strani pa njihova pozitivna stališča do zgodnjega učenja tujih jezikov, izjemen občutek za pravilen pristop k zgodnjemu učenju tujega jezika in predvsem njihovo veliko željo po boljšem poznavanju te teme.
Julijana Vučo: O učenju jezikov (pogled v zgodovino glotodidaktike: od pradavnine do druge svetovne vojne)
Authors: Kalenić Ramšak Branka
Published: February 2015

Vučo, Julijana (2012): O učenju jezikov: pogled v zgodovino glotodidaktike: od pradavnine do druge svetovne vojne (prevod Nada Colnar). Ljubljana: Znanstvena založba Filozofske fakultete. ISBN 978-961-237-522-5, mehka vezava, 295 strani, 27,90 EUR
Uvodnik
Authors: Lah Meta
Published: February 2015

Spoštovana bralka, cenjeni bralec,pred vami je četrta dvojna številka revije Vestnik za tuje jezike. Revija tokrat prinaša pester nabor člankov domačih in tujih avtorjev z različnih področij. Področja so dokaj enakomerno zastopana. Avtorji prihajajo z različnih fakultet, s slovenskih srednjih in osnovnih šol; objavljamo tudi prispevek Katarine Ule, ki je povzetek diplomske naloge na aktualno tematiko. Posebej nas veseli, da tokrat prvič lahko objavljamo tudi članka s področja jezika stroke: Nataša Gajšt in Nives Lenassi s svojima prispevkoma posegata na področje angleščine oziroma italijanščine.Številka prinaša večje število recenzij.Naj vas, cenjeni bralci, povabim še k sodelovanju: prispevke za naslednjo številko sprejemamo do 30. junija 2013.Prijetno in zlasti koristno branje vam želim,Meta Lah
Zdeňka Schejbalová: Česko-francouzský a francouzsko-český slovník základní terminologie speciální pedagogiky
Authors: Perko Gregor
Published: February 2015

Schejbalová, Zdeňka (2009): Česko-francouzský a francouzsko-český slovník základní terminologie speciální pedagogiky. Brno: Masarykova univerzita, Pedagogická fakulta. 196 pages, ISBN 80-210-5072-3 (+ CD-ROM), broché, 270 kč
Zdeňka Schejbalová: L‘évolution des fonctions de l‘article partitif en français
Authors: Perko Gregor
Published: February 2015

Schejbalová, Zdeňka (2003): L‘évolution des fonctions de l‘article partitif en français. Brno: Masarykova univerzita, Pedagogická fakulta. ISBN 80-210-3229-4, broché, 50 kč
Sonia Vaupot: Introduction à la civilisation française
Authors: Schlamberger Brezar Mojca
Published: February 2015

Vaupot, Sonia (2012): Introduction à la civilisation française. Ljubljana: Znanstvena založba Filozofske fakultete. ISBN 978-961-237-548-5, mehka vezava, 137 strani, 13,50 EUR
Transformation of Flaubert’s Free Indirect Speech in Film Adaptation Madame Bovary by Claude Chabrol
Authors: Gacoin Marks Florence
Published: February 2015

The paper deals with the transformation of Flaubert’s free indirect speech in the film Madame Bovary by Claude Chabrol. Conversion of free indirect speech into direct speech or into narration by an external narrator (voice-over) cannot be avoided, it does, however, pose many problems because of the potential ambiguousness (polyphony) of free indirect speech. In such cases, Chabrol often finds effective solutions which bring the film closer to Flaubert’s style. Nevertheless, it remains clear that film adaptations of literary masterpieces entail serious losses. Therefore teachers must convince students that film adaptations of high-quality literature can never replace literary works themselves. Literature and film are two different media, based on distinct types of artistic expression, and should be presented as such to students. As a consequence, film adaptations of literary masterpieces should not uncritically be considered as the most suitable material in all teaching contexts.Key words: Gustave Flaubert, Claude Chabrol, Madame Bovary, free indirect speech, literature and film
Interculturality and Social Awareness in a Spanish-as- a-Foreign-Language Classroom - a Solution to Conflicts Stemming From the Predomination of One Culture
Authors: Ramallo Cuesta Lucía
Published: February 2015

The society of today promotes intense intercultural contact due to factors such as globalization, trade or human migration. To overcome cultural conflicts and ensure that communication exchange is completely adequate to its context, it is imperative that foreign language learners develop intercultural competence. Through intercultural dialogue and the development of social consciousness we strive to disintegrate the injustices suffered by most deprived cultures. If we allow the dominance of one culture over the other, we are implicitly accomplices to negative consequences such as xenophobia or discrimination.If human beings have a great responsibility, greater still is our responsibility as educators, given the cultural character of our profession; teaching a foreign language must inevitably favor the development intercultural speakers.This article proposes solutions to put theory into practice in the classroom of Spanish as a foreign language.Key words: interculturality, intercultural skill, social consciousness, cultural shock, foreign language acquisition