bluuebunny/crossref_metadata_2025 huggingface dataset:
Interdependence between erythrocytes homeostasis indices and structural and functional heart parameters in hypertensive encephalopathy patients
Authors: Ruzov V. I. , Krestjyaninov M. V. , Gavrilova M. S. , Gorbunov V. I. , Mashin Ye. V. , Melnikova M. A. , Skvortcov D. Yu. , Halaf H.
Published: June 2020

Investigation aim is to expose sex features of interdependence between erythrocytes homeostasis indices and heart remodeling in essential hypertension (EH) and hypertensive encephalopathy (HE) patients. 168 patients (110 men) with EH 2th staid, 2th degree and HE 1—2th staid were enrolled. It was executed blood test, echocardiography by standard method. In men erythrocytes homeostasis indices correlated with structural and functional alterations. In women erythrocytes homeostasis indices correlated with diastolic function. There were exposed sex-specific interdependence between erythrocytes homeostasis indices and heart remodeling.
Multiple sclerosis prevalence and risk factors among the Altai Region population
Authors: Smagina I. V. , Ignatova Yu. N. , Yelchaninova S. A. , Fedyanin A. S.
Published: June 2020

In Altai Region, Russian Federation, multiple sclerosis (MS) prevalence is found in 39,9 cases of 100000 with wide variation in certain areas of the territory and ethnic corridor widening. Genotypes HLA-DRBI (13/15, 15/15, 15/3, 3/other) are associated with MS risk factors; recent illnesses (before 15 years old), such as chickenpox, rubella, herpes, chronic tonsillitis, and also head trauma before the illness debut are not associated with MS hazard.
Evaluation of life quality in patients with hereditary neuropathy Charcot—Marie—Tooth in the Krasnoyarsk Region
Authors: Shnayder N. A. , Gluschenko Ye. V. , Kozulina Ye. A.
Published: June 2020

To assess the life quality in patients with hereditary neuropathy Charcot—Marie—Tooth in the Krasnoyarsk Region. Life quality was assessed in 28 patients with confirmed diagnosis of hereditary neuropathy Charcot—Marie—Tooth, using the «EuroQuality of Life — 5 Dimention», Rankin scale. A significant decline in the quality of life in patients with hereditary neuropathy Charcot—Marie—Tooth suggests the need to develop strategies for their physical, medical and social rehabilitation.
Magnetic resonance imaging in diagnosis of thoracic disc herniations: correlation of radiological and clinical symptoms
Authors: Krotenkov P. V. , Kiselyov A. M. , Kotov S. V. , Krotenkova O. V.
Published: June 2020

Magnetic resonance imaging (MRI) was used for diagnosis of thoracic disc herniations and for management strategy determination. 24 symptomatic patients underwent MRI using sagittal T1 and T2-weighted spine echo and axial multiplanar gradient refocused images. Disc herniations were classified according to their size, location in the spinal canal and to the extent of cord compromise. MRI data correlated with the neurological status in all cases and assisted in the management strategy determination. 10 (41,7%) patients with small disc herniations and compression of subarachnoid space demonstrated pseudoradicular syndrome and were managed conservatively. 14 (58,3%) patients with medium or large disc herniations and compression of the cord demonstrated myelopathy or radicularpathy syndrome and were managed surgically. Our results show that MRI is a useful diagnostic tool for diagnosis, management strategy determination and assessment of treatment results.
Clinical efficacy of long-term treatment in patients with vascular dementia
Authors: Suvorova I. A.
Published: June 2020

To study efficacy and safety of prolonged course of cerebrolysin therapy in vascular dementia, 48 patients, aged from 59—77 years, with mild and moderate dementia have been studied. A potential of 3-years course of cerebrolysin therapy to slow down the progression of cognitive impairment in patients with vascular dementia has been studied in the open study. Efficacy and safety of cerebrolysin were assessed clinically and with a battery of widespread scales and neuropsychological tests. The improvement of cognitive, functional and motor activities in patients with mild and moderate dementia indicate the high effectiveness of cerebrolysin. A prolonged therapy allows to prevent the progression of cognitive impairment and development of vascular dementia.
Sensory structures of lungs and airways
Authors: Filippova L. V. , Nozdrachev A. D.
Published: June 2020

The оptimum realization to respiratory function depends on varied sensory feedbacks from ensemble of the sources of the body. Pulmonary sensory receptors are the initiating sites for lung reflexes. The information arriving from lungs and airways information is one of the most important feedbacks that provide the adaptation of the respiratory centre for producing of the pattern optimal in terms of work and force of breathing. In article the review of currently existing data about morphology and functional characteristics of sensitive pulmonary structures is presented: slowly adapting stretch receptors, rapidly adapting receptors, C-fiber receptors and neuroepithelial bodies.
Parathyroid glands autotransplantation in the postoperative hypoparathyroidism prevention
Authors: Popov O. S. , Logvinov S. V. , Lyan N. I. , Larionov M. M. , Galyan A. N. , Gasparyan S. N. , Geydarov R. Ya. , Galyan Ye. V. , Baikov A. N. , Udut V. V.
Published: June 2020

The surgery results analysis of 615 patients with various thyroid disorders was carried out. The percentage of postoperative hypoparathyroidism amounted 1,14%. In order to prevent postoperative hypoparathyroidism in the course of experiment, the method of endovascular autotransplantation of accidentally removed or deprived of supply parathyroid glands was developed.
Opisthorchosis liver abscesses
Authors: Tskhai V F. , Brazhnikova N. A. , Merzlikin N. V. , Maksimov M. A. , Saipov M. B. , Yeskov I. M. , Khlebnikova Yu. A.
Published: June 2020

There are studied frequency of abscesses of a liver at chronic opistorchosis; the reasons of cases; features of clinic, diagnostics, treatment. Laboratory, morphological, instrumental and clinical methods were applied. From 1 170 patients operated concerning complications chronic opistorchosis, liver abscesses are taped at 31 (2,6%) with a long and massive invasion. In 90,5% of cases they were cholangiogenes. The clinic was charactericed by a septic condition. At ultrasonography it is taped two types of the image: corresponding stages of infiltration and a parenchyma destruction. Surgical tactics is individual: at 6 patients — transcutaneum drainage, at 12 — drainage by Melnicov, at 13 — a liver resection. Necessarily external drainage of biliar ducts. 4 persons were died. Features: 1) abscesses in most cases are plural; 2) good effect from concervative treatment at the kept passage of bile; 3) propensity to relapse.
The etno-population features of IL-1 β gene polimorfism distribution at Helicobacter pylori-associated gastroduodenal pathology
Authors: Ageeva E. S. , Shtygasheva O. V. , Ryazantseva N. V. , Kharkov V. N. , Stepanov V. A.
Published: June 2020

The aim of this study was to reveal the features of association polymorphisms of interleukin-1 IL-1 and the antagonist of receptor for interleukin-1 IL-1Ra gene polymorphism in Mongoloids and Caucasoid from Khakassia with HP-associated gastroduodenal pathology (chronic gastritis and gastric ulcer). It was revealed that among Khakasses the most widespread genotypes among Khakasses are СС IL-1β and R4R4 IL-1Ra. The association of СС +3953 and R2R3 genotypes with GU risk in Caucasoids was found.
Magnetic-lazer modulation of specific humoral immunity in pregnant women with anemia
Authors: Yuriyev S. Yu. , Aristova I. V. , Levitsky Ye. F. , Shakhova S. S. , Krotov S. A.
Published: June 2020

This article presents the comparative analysis of humoral and cellular immunity indicators under the influence of magneticlaser effect in 2 frequency ranges (150—1 5000 Hz) for treatment of pregnant women with mild anemia against the background of chronic gastritis, associated with contamination gastrointestinal tract Helicobacter pylori. The application of magnetic-laser effect in frequency 150 Hz allows to raise of hemoglobin lowers the titre of antibodies to Helicobacter pylori. The moderate stimulation of Th1 link withoit activation of humoral immunity is optimal in treatment of benign anemia of pregnancy.
Influence of individual behavioral risk factors (smoking, drinking) on mortality in the population cohort of adult people 20—59 years old in Tomsk (17-year prospective study)
Authors: Seryakova V. A. , Dolgalyov I. V. , Obraztsov V. V. , Tsimbalyuk I. V. , Karpov R. S.
Published: June 2020

In 17-year prospective cohort study, we analyzed the influence of smoking and drinking on the formation of cardiovascular and general mortality of adult people in Tomsk. The cohort included 1 546 people (630 men and 916 women) aged 20—59 years. It has been found that due to smoking the 17-year risk of death by any cause increases 2.4 times among men and 2.7 times among women. The increase in the frequency of drinking in the male population increase the risk of death by any cause 1.6 times (for men drinking once a month or more rarely), 2.4 times (for men drinking once a week and more rarely, but more often than once a month), and 3.8 times (for men drinking more often than once a week). The risk of death by cardiovascular diseases increases 1.7, 2.9, and 4.9 times, respectively.
Analysis of the combined effect of polymorphisms interferon genes OAS1, OAS3, PKR, IFNA17 and IFNG in susceptibility to chronic viral hepatitis C
Authors: Bychkov V. A. , Ryazantseva N. V. , Novitsky V. V.
Published: June 2020

Interferon system plays a key role in the antiviral response. Based on data from the literature, the most dangerous for the development of infectious diseases is the combination of risk alleles of several genes. This study focuses on the analysis of the combined effect of single nucleotide polymorphisms of interferon system genes OAS1, OAS3, PKR, IFNA17 and IFNG in the predisposition to chronic viral hepatitis C. It has been shown that the accounting of several risk genes improves the prediction of development of this disease.
The regulation mechanisms of contractile activity of smooth muscle cells: reactive oxygen species role
Authors: Gusakova S. V. , Baskakov M. B. , Kovalev I. V. , Zheludeva A. S. , Smagly L. V. , Medvedev M. A. , Orlov S. N.
Published: June 2020

The effect of modulation of hydrogen peroxide, nitric oxide and hydrogen sulfide on contractile reactions of smooth muscle cells caused by depolarization, phenylephrine and solutions with altered osmolarity has been investigated by the mechanographical method. The new data of the fundamental nature of the role of reactive oxygen species in the operation of calcium and cGMP-mediated intracellular signaling systems, as well as in volume-dependent regulation of smooth muscle contraction.
Spectrum of intraarticular structures’s changes in patients with hemophilic artropathy by magnetic resonance imaging
Authors: Zavadovskaya V. D. , Ogorodova L. M. , Zhogina T. V. , Mayevskaya Z. A. , Remzantseva I. S. , Borodin O. Yu. , Shakhova I. V.
Published: June 2020

The results of joints's magnetic resonance imaging of 10 patients with severe form of hemophilic artropathy are discussing in this article. The purpose of research was to study the state of soft tissue and bone intraarticulare's structures in present group of patients. The form of bones, condition of an articulate cartilage, the joint’s tendons and ligaments, synovium, presence of an intraarticulate exudate, presence and extent of adjournment haemosiderin, and also signal characteristics of a marrow were estimated.
Effect of alloxan on glutathione system and oxidative protein modification in adipocytes of rats at experimental diabetes
Authors: Ivanov V. V. , Shakhristova Ye. V. , Stepovaya Ye. A. , Novitsky V. V.
Published: June 2020

There was carried out a research of the development of oxidative stress, the condition of glutathione dependant system of antioxidant protection in adipocytes of epididymal adipose tissue of rats when injecting alloxan. The development of oxidative stress in adipocytes was characterized by the increase of lipids hydroperoxide concentration, products reacting with thiobarbituric acid, and the increase of carbonylderived protein. Redox-condition in adipocytes was considerably changing that was specified by the decrease of the content of the reduced form of glutathione and tendency to the increase of glutathione disulfide content, decrease of ratio between reduced and oxidized forms of threepeptide. Damage of protein molecule at oxidative stress may lead to the abnormality of transduction of insulinic signal and appearance of insulin resistance in adipose tissue.
The influence of physical, chemical and biological manipulations on surface potential of calcium phosphate coatings on metal substrates
Authors: Khlusov I. A. , Pichugin V. F. , Gostischev E. A. , Sharkeyev Yu. P. , Surmenev R. A. , Surmeneva M. A. , Legostayeva Ye. V. , Chaikina M. V. , Dvornichenko M. V. , Morozova N. S.
Published: June 2020

The electret voltage indices of artificial surfaces are dependent on coatings formation technology and may be regulated by means of change in their physical-chemical parameters. Chemical modification of radio frequency magnetron calcium phosphate coatings (RFMCPC) by means of silicious incorporation led to an augmentation of pieces’ electrostatic potential. A complication of RFMCPC relief that was fixed by roughness index Ra is accompanied by increase in electret voltage index of artificial surface and its statistical deviation. Bone marrow cells suspension in model biological electrolyte populated RFMCPC dimples. In this manner it modulated the amplitude and leveled out the differences of surface electrostatic potential.
Effect of nettle, burdock, dandelion and galega water extracts on postprandial hyperglycemia and hyperlipidemia in experimental type 2 diabetes mellitus
Authors: Nasanova O. N.
Published: June 2020

In experimental type 2 diabetes mellitus, caused in rats with streptozotocine intraperitoneal injection, the nettle and galega water extracts decrease, burdock extract increases the postprandial triglycerides level, nettle extract decrease the summary blood content of very low density and low density lipoproteins. The dandelion extract doesn’t change the disturbed blood glucose and lipid content.
The treatment of the chronic cardiac failure in patients with type 2 diabetes mellitus in clinical practice
Authors: Lityaeva T. Yu.
Published: June 2020

Ethnofactors of chronic cardiac failure (CCF) include type 2 diabetes (D-2). The treatment of patients with diabetes and chronic cardiac failure is very problematic. The aim is to reveal the CCF prevalence rate among D-2 patients in a representative sample of respondents in Orenburg and to assess their treatment. Two groups of D-2 patients were analyzed: the first group consisted of unorganized urban population patients, and the second group consisted of hospital patients. The CCF prevalence rate in patients of the second group (78%) was quite comparable with that in the first group (82%). The analysis of efficiency of CCF treatment in the representative sample has shown that drug treatment was not sufficient from the cardiologist’s point of view. CCF complicates D-2 in most patients. The current therapy aimed at the correction of cardiovascular disorders in patients with diabetes and cardiac failure calls for optimization in accordance with national recommendations.
Implant of porous titanium nickelide impregnated with autologous blood monocytes for the formation of orbital stump in the experiment
Authors: Gorbunova Ye. A. , Krivosheina O. I. , Zapuskalov I. V.
Published: June 2020

In the experiment in vivo we studied the regenerative course after intraorbital implantation of porous titanium nickelide impregnated with autologous blood monocytes and without them after evisceroenucleation. It was revealed that introduction of autologous blood monocytes stimulates the growth of collagen fibers and new vessels, accelerates the process of regeneration and formation of orbital stump.
Using the method of laser spectroscopy in the evaluation of the therapy effectiveness in patients with severe bronchial asthma
Authors: Krasnobayeva L. A. , Selivanova P. A. , Starovoitova Ye. A. , Kulikov Ye. S. , Kirillova N. A. , Kistenyov Yu. V. , Ogorodova L. M. , Nikiforova O. Yu. , Fokin V. A. , Mochula A. V. , Mochula O. V.
Published: June 2020

Because of the shortcomings of existing methods of assessment of inflammation activity in the airways, the method of laser optic-acoustic spectroscopy of patients expired air considered using for this purpose. This method can be used to indirectly evaluate the activity of inflammation in the airways and as an additional criterion for the effectiveness of basic treatment in patients with asthma.
Clinical and functional results of the retinal detachment treatment by combined pneumoretinopexy
Authors: Dashko I. A. , Krivosheina O. I. , Khoroshikh Yu. I.
Published: June 2020

The article contain the results of retinal detachment surgical treatment with help of the new method, lie on pneumoretinopexy with epiretinal introduction of the collalisinum and the transscleral removal of subretinal liquid into retrobulbar space. There is shown that, the introduced method in comparison with traditional extrasclearal operations, is defined less traumatic, makes for stable clinical and functional results in the postoperational period and permits to reduce the number of complications, including the retinal detachment relapse.
The efficiency of surgical and laser treatment of the age-related macular degeneration wet form
Authors: Khoroshikh Yu. I. , Krivosheina O. I. , Zapuskalov I. V.
Published: June 2020

The results of comparative analysis of the efficiency between different sorts of the age-related macular degeneration treatment wet form has been presented in the article. There was demonstrated that choosing the treatment tactics in such pathology patients used to consider the clinical form and the stage of the disease. The wet form needs pneumoretinopexy with following of retina laser coagulation. The subretinal fibrovascular membrane is indications for transcilliary vitrectomy with removal of proliferate tissue. The traditional medical treatment of wet form of age-related macular degeneration does not ensure stable clinical and functional results.
Medical and social aspects of aged population mortality in the Omsk Region
Authors: Erofeyev Yu. V. , Migunova O. V.
Published: June 2020

Problems of aged population mortality lead to massive increase in total expenses on health service. Stability of mortality rate was primary cause of population type in Omsk Region was estimated as regressive. It was high level of demographic old age in the region, death rate at the age of 60—70 remain high. Record of tendencies of mortality is one of the most important tasks of social policy.
Medical aid arrangements for arterial hypertension patients in the areas of Irkutsk Region which were characterized by low accessibility of specialized medical aid
Authors: Sinkov A. V. , Sinkova G. M.
Published: June 2020

The complex of medical aid arrangements for arterial hypertension patients in the rural and farthest areas of Irkutsk Region which were characterized by low accessibility of specialized medical aid was developed. The complex make possible to improve awareness, treatment and control of arterial hypertension.
Subpopulation structure of regulatory Т-cells of blood in patients with multiple drugresistant pulmonary tuberculosis
Authors: Churina Ye. G. , Novitsky V. V. , Urazova O. I. , Voronkova O. V. , Kolobovnikova Yu. V.
Published: June 2020

Subpopulation structure of regulatory T-cells of peripheral blood in patients with newly diagnosed pulmonary tuberculosis depending on the clinical form of disease and sensitivity of Mycobacterium tuberculosis to anti-tuberculosis drugs have been analyzed in this work. It has been shown that in formation immune suppression at infiltrative, dissemination and fibrosis-cavity pulmonary tuberculosis the leading part play natural regulatory CD4+ CD25+ Foxр3+ -T-lymphocytes. Thus increase of their number in blood at drug-resistance and drugsusceptible patients. It has been demonstrated that in patients with fibro-cavernous and infiltrative form of the disease and drug-resistance pulmonary tuberculosis the number of CD4+ CD25- Foxр3+ -regulatory T-cells were increasing.
Comparative analysis of the EEG components and heart rate variability during biofeedback training, depending on the serotonin serum level at girls 15—17 years
Authors: Krivonogova Ye. V. , Poskotinova L. V. , Dyomin D. B.
Published: June 2020

The aim is analysis of EEG-rhythms spectral capacity during biofeedback session by heart rhythm variability (HRV) parameters in dependence from serum serotonin level. The were surveyed 53 girls 15—17 years of Arkhangelsk. The girls with a deficit of serotonin to achieve positive results biofeedback-training is accompanied by desynchronization EEG components, which results in reduced spectral power of EEG α-, β- and θ-activity. At the level of serotonin in the blood serum in the normal range for girls is an increase in spectral power of α-activity in thethe anterior parts of of the brain.
Influence of blood autologous mononuclear on regenerative processes at stromal corneal damages to experiment
Authors: Levchenko N. A. , Krivosheina O. I.
Published: June 2020

In experiment in vivo laws of regeneration of damages of a cornea on background intrastromal introductions of autologus mononuclear blood are studied. It is proved, that local application of mononuclear cells significantly reduces the duration and expressiveness of inflammatory process and as consequence, is accelerated process of regeneration of the damaged corneal tissue.
Association of insertion deletion polymorphism of the ACE gene with factors of circulating rennin-angiotensin-aldosterone system and endothelial function of skin microvassals in preeclampsia
Authors: Radkov O. V. , Kalinkin M. N. , Zavarin V. V.
Published: June 2020

The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with plasma ACE, renin activity and endothelial function of skin microvassals were studied. Preeclamptic patients with the DD genotype of ACE I/D gene polymorphism have lowest plasma renin activity level and endothelium-dependent vasodilatation, D allele carriers have highest plasma ACE activity.
Vascularisation of the ileocecal valve
Authors: Sotnikov A. A. , Kazantsev I. B.
Published: June 2020

Knowledge of the ileocecal anastomosis of the intestine are of great practical importance. Therefore, the aim of our study was to examine circulation ileocecal obturator apparatus. The study was conducted on 30 samples of ileocecal angle by a liqueur a. ileocolica 3% solution of gelatin with black ink, and further dissection artery and its branches. Anastomoses mesenteric arteries were studied using the technique transillumination under a beam of directed light. Artery ileocecal valve were studied using mikropreparovki with forehead binocular microscope with an increase in x3. The study identified an additional anastomoses with the anterior cecal artery, and also showed that blood flow to the lips bauginievoy damper is closed around the ostium ileocecale arterial ring.
Chronic osteomyelitis in children: prognosis of the current and ways of patients’ rehabilitation
Authors: Fedotov V. K.
Published: June 2020

For improvement results of the treatment of children with chronic osteomyelitis author offers to put into practice more frequent control examinations of patients and definition direction of the current of local pathological process with help elaborated the prognostic table. At the same time are recommended different variants of treatment and rehabilitation until the patient be under observation.
New presentation about functional biomehanic of ileocecal valve
Authors: Kazantsev I. B.
Published: June 2020

In spite of the fact that at present exists quite a few operative methodses, directed on reconstruction of insolvency lieocecal valve, united opinion, for functions given division of the bowels no. The aim of our study was to examine the biomechanics of the closer abilities of ileocecal valve, according to deep study of the anatomical forming the area ileocecal junction. In the course of studies was installed that in rate deskside ileocecal junction, external ligaments, pleats of the wall of the caecum, original musclearchitectonic, as well as geometry of the lips Bauhin’s dampers, play the important role in mechanism of the closing ileocecal valve.
Metabolic effects of nettle extract in diabetes mellitus
Authors: Yakimova T. V. , Nasanova O. N. , Meleshko M. V. , Burkova V. N.
Published: June 2020

The blood level of glucose, glycosylated hemoglobin, triglycerides, total cholesterol, summary content of very low density and low density lipoproteins, high density lipoproteins glycosylation's degree had been decreased with the nettle (Urtica dioica) extract in experimental diabetes mellitus type II in rats that was being caused with streptozotocine intraperitoneal injection and high-fat diet. The effect did not depend on food regimen during the therapy. The cholesterol atherogenic index has been decreased and the sensitivity to insulin has been recovered with the nettle extract when high-fat diet only. The level of blood glucose and glycosylated hemoglobin has been decreased with metformin when usual food regimen during the therapy. The lipid content and cholesterol atherogenic index has been normalized with metformin when both variant of diet.
Elaboration the project of officinal article on the substance of brown sphagnum (Sphagnum fuscum L.)
Authors: Kelus N. V. , Sheykin V. V. , Gundareva A. K. , Kaidash O. A.
Published: June 2020

Having purposed to find efficient vegetable sorbents, adsorptive qualities of solid raw materials of 3 sorts of wide-spread in West Siberia sphagnous mosses (S. fuscum, S. balticum, S. fallax) was learnt. The largest values of adsorptive activities accor ding to markers (model substances) from them are typical to species of S. fuscum. Physical-chemical and technological qualities of substances of this species brought in project of officinal article are learnt.
Elaboration of technology and comparative research of pellets of tamsulosin the modified liberation
Authors: Blynskaya Ye. V. , Uvarov N. A. , Lazareva Ye. Ye. , Alexeyev V. K.
Published: June 2020

The work purpose consisted in elaboration of technology of reception pellets of tamsulosin with the modified liberation, and also an estimation of their comparative bioequivalence with a comparison preparation. Their bioequivalence judged by results of treatment of rats with experimental good-quality hyperplasia of prostatic glands. By results of researches the structure and technology pellets of tamsulosin are proved, their bioequivalence with a comparison preparation is proved.
Voltammetry application for quantitative definition of L-Thyroxine
Authors: Dome S. V. , Ivanovskaya Ye. A.
Published: June 2020

The technique of quantitative determination of L-thyroxin in a model solution and an individual preparation with the aid of inversion voltammetry is developed. For this purpose, it is necessary to study working conditions of the voltammetric behavior of L-thyroxin, namely, to estimate the influence of different factors (accumulation potential, accumulation time, scanning rate, nature of background electrolyte) on the potential and current of thyroxin recovery. The object of study is L-thyroxin (Sigma, USA). As a result, working characteristics of quantitative determination of L thyroxin in a model solution and monopreparation are determined.
The methodic of approach to optimization of drugs list served of private citizens
Authors: Dzhuparova I. A. , Borisova O. A.
Published: June 2020

It was developed the methodic of approach to the drug's position served of private citizens; it was make up the matrix the position and maps of perception of drugs.
Risk management role in system of Republic Sakha (Yakutia) medicinal maintenance
Authors: Tarabukina S. M. , Moshkovа L. V.
Published: June 2020

With application of expert estimations the most significant factors causing risk for medicinal maintenance of the population, living in certain territorial zones Republics Sakhas (Yakutia) are revealed. The complex of actions for decrease and management of risks in system of medicinal maintenance of republic are scientifically proved and developed. The differentiated approach to formation of trading extra charges on preparations is offered. The design procedure of the size of subventions is developed at preferential medicinal maintenance of the citizens living in remote and sparsely populated areas of republic.
Application of neuroprotectors in severe brain injuries
Authors: Vaizova O. Ye. , Zautner N. A. , Alifirova V. M. , Kolmakov D. V. , Golovina Ye. L. , Molodykh A. S.
Published: June 2020

Blood concentration of protein S100 was been decreased with choline-liked neuroprotectors citicoline and choline alfoscerate in clinical trial 52 patients in early day after stroke. Concentration of neuron-specific enolase was been decreased with three month mildronat therapy in blood of 16 patients with traumatic brain injury. Neuroprotective therapy has stabilization of blood-brain barrier as result.
The comparative anatomic morphological study of Bidens L. species
Authors: Isaykina N. V. , Andreyeva V. Yu.
Published: June 2020

The purpose of research is to learn morphological and anatomical structure of Bidens L. types for elaboration of normative documentation's project of the herb bur-marigold. Morphological and anatomical features of production samples formal raw-materials and other Bidens L. types were explored by methods of pharmacopeia. There were revealed essential differences of these types' morphological features and conformity of their anatomical structure.
Phytoestrogens are the correctors of vasomotor and psychoemotional reactions after experimental ovariectomy
Authors: Plotnikova T. M. , Vasiliyeva N. V. , Anishchenko A. M.
Published: June 2020

The effects of Maackia amurensis extract (200 mg/kg, p.o. during the 14 days) on the vasomotor and psychoemotional reactions in rats after ovariectomy were investigated. The Maackia amurensis extract did not change the blood level of sex hormones, showed anxiolytic activity with the models of anxious disorders, did not influence considerably on the motor activity in «open field» test. Maackia amurensis extract reduced the pathological vasomotor reactions, showing by the change in vessels reactions on vasoactive agents and «hot flushes».
Determination of Hodgkin and non-Hodgkin lymphoma stage with combined positron-emission and computed tomography
Authors: Boikov I. V. , Trufanov G. Ye. , Ipatov V. V.
Published: June 2020

126 patients with histological diagnosis of Hodgkin and non-Hodgkin lymphoma were examined using combined positronemission and computed tomography with radiotracer 18F-deoxyglucose. For staging Ann Arbor classification (1971) with Costwolds modification (1989) was used. The combined positron-emission and computed tomography pattern of Hodgkin and non-Hodgkin lymphoma was established. Morphofunctional characteristics of lymphoma were determined in cases of lymph node, spleen, liver, kidneys, bones and lung lesion. Using combined positron-emission and computed tomography it can provide more accuracy in staging of Hodgkin and non-Hodgkin lymphoma.
Working out of telemedical consultations automated system
Authors: Syryamkin V. I. , Baikov A. N. , Bureyev A. Sh. , Zhdanov D. S. , Osipov A. V.
Published: June 2020

In the article problems of system engineering of telemedical consultations are considered, the analysis of world approaches to their construction is carried out. The group of authors represents the developed system of asynchronous telemedical consultations, its architecture and advantages before existing analogues.
Psychovegetative features at sick of the cirrhosis
Authors: Filippova L. P. , Beloborodova E. I. , Beloborodova Ye. V. , Alekseyeva A. S. , Shepeleva Ye. G.
Published: June 2020

Complex kliniko-tool, laboratory, psychovegetative investigation of 139 various aetiologies sick by a cirrhosis (virus, alcoholic, mixed) is carried and severity levels on Childs-Pugh. The comparison group has been presented by 104 sick chronic hepatitises virus, alcoholic and mixed aetiologies. The control group included 30 healthy the person comparable floor and age. At sick of a cirrhosis, also as at sick of a chronic hepatitis, emotionally-labile, neurotic lines and high personal uneasiness prevailed. The tendency to sympathicotonia depended on weight of defeat of a liver. Prevalence of a tone and reactance of sympathetic department of vegetative nervous system is a compensatory strengthening of adaptive mechanisms.
Experimental basis of surgical treatment for expiratory collapse of the trachea and main bronchial tubes
Authors: Dambayev G. Ts. , Topolnitskiy Ye. B. , Shefer N. A. , Khodorenko V. N. , Fomina T. I. , Baikov A. N. , Gyunther V. E.
Published: June 2020

Original surgical treatment for tracheobronchomalacia using external stabilization of movable segment with titanium nikelide implant has been developed. The experimental study was performed on 10 mongrels. Tracheomalacia was created by submucosal resection of tracheal cartilages. Efficacy of the method was tested using clinical, radiological, endoscopic and morphological examination. It is ascertained, that the technique permits to eliminate redundant mobility of tracheal segment simply and reliably.
Natural dynamics of hypertriglyceridemia: incidence, regression, mortality from cardiovascular diseases and all causes (according to the results of a 17-years prospective study)
Authors: Dolgalyov I. V. , Tsimbalyuk I. V. , Obraztsov V. V. , Seryakova V. A. , Konko T. Yu. , Trotsenko B. A. , Karpov R. S.
Published: June 2020

In 17-year nested prospective study, the natural dynamics of hypertriglyceridemia (HTG) (development of new cases, regress), cardiovascular mortality and other mortality of patients with HTG have been examined. The nest included 630 men and 916 women from 20 to 59 years old. The HTG incident in the nest was 8.24 cases per 1000 people*years of observation. Among people 20—29 years old, new HTG cases were observed more often in men, while in the age interval of 30—59 years, new cases were more often observed in women. For the period of observation, the HTG occurrence increased 1.6 times in men and 2.1 times in women. HTG is characterized by the low course stability, and the regress level is independent of sex. Among men and women, Among men and women with HTG, brain stroke and cardiovascular mortality is higher than that among people with the normal triglyceride (TG) level. The TG level did not affect the total men mortality.
Sanogenetic mechanisms of transplantation action of the whole cells and their nuclear fraction on experimental dislipoproteinemia model
Authors: Pivovarov Yu. I. , Kurilskaya T. Ye. , Sergeyeva A. S. , Babushkina I. V. , Baduyev B. K. , Borovsky G. B.
Published: June 2020

Research objective was to compare effects of transplantation of cells and their nucleus on model alimentary dislipoproteinemia. Experiment is executed on the rabbits containing on an atherogenous diet. In blood serum of animals studied changes of a lipide exchange, in a liver — level of stresses-proteins, morphological changes and the maintenance of markers of an apoptosis and a proliferation. Also estimated the area of atherogenous plaques and a thickness of intima of an aorta. It is shown that unlike cellular transplantation, introduction of nucleus led to more expressed therapeutic effect and inhibition of expansion of leading links of an atherogenesis.
Polymorphism of DNA repair genes XRCC1 280, XRCC1 194, XRCC1 339 and XPD 751 with stomach cancer
Authors: Rakitin S. S. , Dmitriyeva A. I. , Novitsky V. V. , Kuznetsova I. A. , Avkhimenko B. A.
Published: June 2020

We evaluated the frequency distribution of polymorphic variants in DNA repair genes XRCC1 280, XRCC1 194, XRCC1 399 and XPD 751 gastric cancer patients and healthy controls, leading to new fundamental knowledge and molecular genetic markers of gastric cancer. Statistically significant differences were identified in the two groups for the three excision repair gene XRCC1 280, XRCC1 399 and XPD 751, relative risks were calculated of gastric cancer in carriers of the minor variants of these genes.
Prevention of peritoneal adhesions using antioxidant complex in the experiment
Authors: Tikhonov V. I. , Plotnikov M. B. , Logvinov S. V. , Grishchenko M. Yu. , Shkatov D. A. , Semichev Ye. V.
Published: June 2020

In the analysis of known ways to prevent adhesions, by which the proposed alternative effects on the formation of adhesions in the abdominal cavity. We analyze the effect of antioxidant complex formation of adhesions in the experiment.
Morfoquantitative and ultrastructural analysis of blood and lymph vessels in the first molars and premolars periodontal ligament
Authors: Khertek M. V. , Logvinov S. V.
Published: June 2020

Morfoquantitative and ultrastructural analysis of the specific volumes of blood and lymph vessels in the periodontal first molars and premolars with different surfaces (medial, distal, buccal, and palatal) and at different levels of the roots are studied. It was noted that at physiological pressure on the molars and premolars, the specific volume of the investigated values are different. Throughout the root of the observed two zones of compression and expansion of periodontal. Depending on these areas of blood and lymphatic vessels was significantly different.
Mechanisms of lymphocyte apoptosis at tick-borne encephalitis
Authors: Chechina O. Ye. , Ryazantseva N. V. , Sazonova Ye. V. , Zhukova N. G. , Udintseva I. N. , Novitsky V. V.
Published: June 2020

Results of the complex research of apoptosis realization of lymphocytes at acute tick-born encephalitis and during long antigenemia condition has been presented in this article. The acceleration of apoptosis, tumor necrosis factor I presentation and the decrease in mitochondrial transmembrane potential of lymphocytes were determined at tick-born encephalitis. Uncovered changes are more appeared at acute neuroinfection.
Gnoseological prolegomena of capacity of knowledge in addiction psychiatry
Authors: Artemiyev I. A.
Published: June 2020

Mental and behavioral personality disorders provoked by substance use — alcohol and drug addictions — are similar in genesis and social consequences and this dictates necessity of gnoseological understanding of terminological apparatus of this phenomenon. Understanding of use of narcotics as a common criterion of gnoseology may testify that namely community comes forward as criterion of summarized data about considered addictions and capacity of knowledge allows considering drug and alcohol abuse as equivalent ones according to their social significance and pathogenetic patterns.
Current approaches to development of contrast agents for MRI diagnostics
Authors: Sorokina K. N. , Tulupov A. A. , Tolstikova T. G. , Ussov V. Yu.
Published: June 2020

Magnetic resonance imaging (MRI) is primarily used in medical imaging to visualize the structure and function of the body and essential tool for diagnostics of broad range of pathologies. But still in a growing number of cases there are indications to use contrast agent to delineate areas of interest and for more precise diagnosis definition. In a review the properties and clinical applications of most popular paramagnetic contrast agents based on Gd(III), Fe(II) и Mn(II) are discussed. It is also focused on discussion of modern experimental targeted contrast agents (conjugates of antibodies, nanoparticles and dendrimers) and advances of their application for early diagnostics of most common pathologies: cardiovascular, cancer and Alzheimer diseases.
EEG CHARACTERISTICS AND THYROID PROFILE RATIO IN ADOLESCENTS OF SUBPOLAR AND POLAR EUROPEAN NORTH AREAS
Authors: Demin D. B. , Poskotinova L. V. , Krivonogova Ye. V.
Published: June 2020

Features of brain bioelectric activity and thyroid system in adolescents living in Subpolar andPolar regionsof the North are considered. Hyperactivity of subcortical diencephalic brain structures in adolescents of the Polar region is revealed. Adolescents of Subpolar region have more intensive age optimization of neurodynamic processes. There are noted latitude distinctions of thyroid hormones role for age formation of brain bioelectric activity in adolescents.
THE STRUCTURE OF THE LIPID PHASE OF THE ERYTHROCYTE MEMBRANE IN PATIENTS WITH EXPRESSED HEMOLYSIS AFTER SURGERY WITH CARDIOPULMONARY BYPASS
Authors: Khokhlov O. A.
Published: June 2020

The composition of lipid phase of red-cell membrane in patients with ischemic heart disease (IHD) with pronounced postperfusion hemolysis (18 patients) before coronary artery bypass surgery and 1 hour after the completion of cardia bypass (CB) has been studied. It is shown that patients with IHD with pronounced hemolysis are characterized by the normal ratio of phospholipids (PL) fractions in red-cell membrane before surgery, which is connected with eth high content of young forms of red cells in blood at this stage. After surgery, the fraction of lysophosphatidylcholine and phosphatidic acid in red-cell membrane increases against the background of decrease of phosphatidylinositol  and phosphatidylcholine, which likely reflects the simultaneous activation of phospholipases of three classes (A, C, and D) in red cells during CB. Regardless of the phase of the study, the total content of PL in red-cell membrane of IHD patients with pronounced hemolysis is decrease at the high level of cholesterol (CS) and the CS/Pl ratio.
BIOFEEDBACK APPLICATION FOR PREGNANT WOMAN TRAINING UNDER MONITORING OF MOTHER – FETUS SYSTEM CONDITION
Authors: Khlopova A. A. , Pekker Ya. S. , Tolmachev I. V.
Published: June 2020

Raining influence with biofeedback on system mother fetus was investigated. The technique of biofeedback training for the pregnant women was developed, which had main objective to control of parameters of vegetative nervous system by means of breath. The technique was tested on a group of pregnant wo men on term of a gestation of 32–35 weeks. It is established: change of a functional condition of mother influences level of sympathetic regulation of a heart rhythm of a fetus.
MOTOR REHABILITATION OF INVALIDS WITH INFRINGEMENT OF LOCOMOTOR FUNCTION DUE TO RESIDUAL PHENOMENA OF STROKE
Authors: Tsirkin G. M. , Jafarova O. A. , Voroninskiy V. A. , Shperling M. M.
Published: June 2020

This paper demonstrates the clinical efficacy of multiparametric biofeedback in patients aged 45 to 60 years with residual phenomena after stroke with 1 to 5 years prescription. Comparison was made according to the international scale. Patients in the control group and the main group were selected at random.It was shown that the use of multiparametric biofeedback allows to reduce spasticity, restore body image and improve hemodynamics, increase adaptive capacity of the body, improve coordination. At the sa me time, when compared with medical therapy of spasticity, this technology is an order higher cost-effective.
BIOBEHAVIORAL THERAPY OF RHEUMATOID ARTHRITIS
Authors: Shabanova N. A. , Shubina O. S. , Ukolova L. A. , Tov N. L.
Published: June 2020

The relevance of the study is connected with need to expand the arsenal of treatment methods patients with rheumatoid arthritis. The study examined the efficacy of biobehavioral therapy in a comprehensive program of treatment patients with rheumatoid arthritis (medical therapy in combination with biobehavioral therapy). It has been shown when compared with the control group (isolated drug therapy) maintaining  clinical  response  in  short-term  follow-up  study  in  the  intervention  group.  Statistically    significant relationship the volitional control of the alpha rhythm of EEG (increased power of the alpha rhythm) with a reduction in pain intensity in the in neurofeedback program and positive dynamics of the main characteristics of the alpha rhythm have been drmonstrated. Inclusion in the treatment program of arthritis biobehavioral approach has reduced the dose of pain medication, so reducing aggression of pharmacotherapy.
ASSESSMENT OF THE ADAPTIVE ABILITIES IN JUNIOR SCHOOL STUDENTS USING GAME BIOFEEDBACK TECHNOLOGY
Authors: Danilenko Ye. N. , Jafarova O. A. , Mazhirina K. G.
Published: June 2020

In this study we selected 3 basic types of the adaptive behavior of the junior school students (n = 80) using a comparative analysis of the psychological and psycho-physiological characteristics in the course of game biofeedback. As a result of training the emotional state of the students normalized and psycho   physiological tension decreased. The ADHD and frequently ill students also got a positive outcome after training.
NEUROFEEDBACK AND EMG TRAINING COMBINING EFFICIENCY STUDY IN 6–9 YEARS OLD ADHD CHILDREN
Authors: Sapina Ye. А.
Published: June 2020

The research goal was to study neurofeedback and EMG combining training efficiency in ADHD children.To achieve the goal three groups were compared before and after training and six months later. Experimental group included ADHD children 6–9 years old. It was divided into two: group A trained thetabeta ratio and muscle tension decrease simultaneously while group B trained only theta-beta ratio decrease. Control group included healthy children. The results showed significant effect of combined EEG and EMG training for self-control improvement, anxiety and muscle tension decrease in comparison with standard EEG training.
ELECTROENCEPHALOGRAPHIC BIOFEEDBACK IMPROVES FOCUSED ATTENTION IN ATTENTION DEFICIT/HYPERACTIVITY DISORDER
Authors: Sokhadze E. M. , Hillard B. , Eng M. , El-Baz A. S. , Tasman A. , Sears L.
Published: June 2020

EEG biofeedback (so called neurofeedback) is considered as an efficacious treatment for ADHD. We propose that operant conditioning of EEG in neurofeedback training mode, aimed to mitigate inattention and low arousal in ADHD, will be accompanied by changes in EEG bands' relative power. Patients were 18 children diagnosed with ADHD. The neurofeedback protocol (“Focus/Alertness” by Peak Achievement Trainer, Neurotek, KY) used to train patients has focused attention training procedure, which according to specifications, represents wide band EEG amplitude suppression training. Quantitative EEG analysis was completed on each of 25 min long twelve sessions to determine the relative power of each of the EEG bands of interest throughout each session, and from the first session to the last session. Additional statistical analysis was performed to determine significant changes in relative power within sessions (from minute 1 to minute 25), and between sessions (from session 1 to session 12) for an individual patient. We performed analysis of relative power of Theta, Alpha, Low and High Beta, Theta/Alpha, Theta/Beta, and Theta/Low Beta and Theta/High Beta ratios. We performed also analysis between the “Focus”measure and changes in relative power of above EEG rhythms and their ratios. Additional secondary measures of patients’ post-neurofeedback outcomes were assessed using an audio-visual selective attention test (IVA + Plus) and behavioral evaluation scores from Aberrant Behavior Checklist. We found that, as expected, Theta/Low Beta and Theta/Alpha ratios decreased significantly from Session 1 to Session 12 and from minute 1 to minute 25 within sessions. The ‘Focus” measure of protocol showed high negative correlation with both Theta/Alpha and Theta/Beta ratios. The findings regarding EEG changes resulting from self-regulation training along with behavioral evaluations will help in elucidation of neural mechanisms of neurofeedback aimed to improve focused attention and alertness in ADHD.