bluuebunny/crossref_metadata_2025 huggingface dataset:
Credit Risk and Profitability of Banking Sector in Sri Lanka
Authors: Bandara Herath Mudiyanselage Kasun Salitha , Jameel Ahamed Lebbe Mohamed , Athambawa Haleem
Published: June 2021

This paper aims to investigate the impact of credit risk on the profitability of the banking sector in Sri Lanka. The profitability is measured with and Return on Assets. At the same time, credit risk is quantified with four indicators: Non-performing loan Ratio (NPLR), Loan to Deposit Ratio (LDR), Net Charge off Ratio (NCOR), and Capital Adequacy Ratio (CAR). Data from thirteen banks over eight years from 2010 to 2017 was analyzed using panel data regression analysis. The finding shows that the Profitability of the Banking Sector in Sri Lanka has been determined by important determinants such as credit risk. The study further finds that non-performing loans have negative and significant return on assets. However, the net charge-off ratio and the loan to deposit ratio are not important variables for expanding the bank's profitability. On the other hand, the CAR positively impacts returns on assets. The study suggested the need to strengthen the management of credit risk in order to preserve Sri Lankan banks' current profitability.
Female Economic Participation and Economic Growth: An Empirical Evaluation of the Nexus for sub-Saharan African Region
Authors: Jemiluyi Olufunmilayo Olayemi , Yinusa Dauda Olalekan
Published: June 2021

More recently, there has been increasing recognition of gender perspective to achieve economic growth and sustainable development. Although the nexus between gender equality and economic growth has enjoyed sizeable consideration in the literature, empirical evaluation of the economic growth effect of female economic participation is few. Hence, this study seeks to examine the relationship between female economic participation and the economic growth process of the sub-Saharan African region. In particular, the study tests whether there is an economic growth premium due to female participation in economic activities using data for a sample of 35 sub-Saharan African economies. Employing the Prais-Winsten regression, the findings suggest the existence of a significant positive effect of female economic participation on economic growth in the region. Specifically, a per cent increase in female employment rate and female labour force participation leads to a 0.028 per cent and 0.021 per cent increase in economic growth. Also, the share of working population, domestic credit to the private sector and urbanization rate are positively correlated with economic growth during the study period. The findings imply that female economic empowerment is important for achieving economic growth in the region; hence empowerment of women and girls should be made focal in national and regional development plans as stipulated in goal 5 of the Sustainable Development Goals (SDG) plan.
LARVICIDAL EFFICACY OF LEAF EXTRACTS FROM THREE ASTERACEOUS PLANT AGAINST MOSQUITO (Culex quinquefasciatus)
Authors: Ojianwuna C. C. , Ilondu Ebele Martina , Enwemime V. N.
Published: June 2021

It is well known that the mosquito, Culex quinquefasciatus, badly affect individuals in endemic setting, causing filariasis. Intervention targeting the vector larva has not been given much priority. Therefore, the efficacy of ethanolic extract of Ageratum conyzoides, Bidens pilosa L. and Spilanthes filicaulis and a mixture of these plants in equal proportion was evaluated for larvicidal activities against filarial mosquito Culex quinquefasciantus. Phytochemical screening of the extracts was done by dissolving 5g each of plants in 30ml ethanol and water separately to obtain plant extracts. Samples were qualitatively screened following standard methodology for phytochemicals. Mortality of mosquito larva was examined after 12hrs, 24hr, 36hrs, and 48hrs treatment. Probit analysis for 50% Lethal Concentration was done using GraphPad Prism 9. Phytochemical screening of the plants revealed that Bidens pilos, Spilanthes filicaulis and Ageratum conyzoides contained moderated concentrations of Anthraquinones and Cardiac glycosids, Tannins, and Alkaloids respectively. Complete mortality was recorded with 0.60ml of Bidens pilosa, and Spilanthes filicaulis at 48hours and 36 hours respectively. More so, complete mortality was recorded with 0.40 and 0.60ml of the three plants in mixed proportion at 36 hours and 24 hours respectively. Larval mortality and time mortality were significantly (p<0.05) different. 50%Lethal Concentration for Ageratum conyzoides L, Bidens pilosa L, Spilanthes filicaulis, and mixture of the three plants in equal proportion are 0.33ml, 0.25ml, 0.08ml, and 0.06ml respectively. Results showed that these plant materials exhibit significant activity and could be considered as potent natural larvicidal agent.
PRODUK MAKANAN UBAH SUAI GENETIK (GMF) DALAM PERSPEKTIF KONSEP HALALAN TOYYIBAN BERDASARKAN PENILAIAN MAQASID HIFZ AN NAFS
Authors: Mohd Fadzli Siti Dzil Nataqhain , Wan Harun Mohammad Amir , Baharuddin Ahmad Syukran , Reza Adnan Muhammad Reza Amin
Published: June 2021

Abstract in English:
Nowadays, research and production of new food products based on genetic engineering technology are carried out to give benefit to the community. However, the production of food products through this technology has raised concerns in the determination of the legal status and the safety of the food products to be eaten by the consumer. Therefore, this article discusses genetically modified food (GMF) in the concept of halalan toyyiban based on the evaluation of maqasid hifz an nafs. This article uses qualitative design through the documentation study method by comparing and analyzing important information from selected sources such as al-Quran, fiqh books, scientific articles, fatwas, and journals from previous research. The results obtained showed that the GMF products are considered to meet the halalan toyyiban concept if the products follow the six principles in the concept which are halal, healthy, accepted by fitrah, safe, clean, and free from syubhah. This study also found that GMF products can be evaluated through three main maslahah (benefit) in maqasid syariah which is dharuriyyat (necessity), hajiyyat (will), and tahsiniyyat (perfection).
 
Abstract in Bahasa Malaysia:
Pada masa kini, penyelidikan serta penghasilan produk makanan baru yang berasaskan teknologi kejuruteraan genetik dilaksanakan bagi memberi manfaat kepada masyarakat. Namun, penghasilan makanan melalui teknologi ini secara tidak langsung telah menimbulkan kemusykilan dalam penentuan status hukum dan keselamatan produk makanan yang akan dimakan oleh pengguna. Oleh itu, artikel ini membincangkan mengenai produk makanan ubah suai genetik (GMF) dalam konsep halalan toyyiban berlandaskan penilaian maqasid hifz an nafs. Artikel ini menggunakan reka bentuk kualitatif iaitu melalui kaedah kajian dokumentasi dengan membandingkan serta menganalisis maklumat penting daripada sumber yang dipilih seperti kitab suci al-Quran, kitab-kitab fiqh, artikel-artikel ilmiah, fatwa-fatwa serta jurnal dari penyelidikan terdahulu. Hasil kajian yang diperolehi menunjukkan produk GMF dianggap menepati konsep halalan toyyiban sekiranya ia mengikut keenam-enam prinsip konsep tersebut iaitu prinsip halal, berkhasiat, diterima fitrah jiwa sejahtera, selamat, bersih dan bebas syubhah. Kajian ini juga mendapati bahawa produk GMF dapat dinilai melalui tiga maslahah utama dalam maqasid syariah iaitu dharuriyyat (keperluan), hajiyyat(kehendak) dan tahsiniyyat (kesempurnaan).
A REVIEW OF CLINICAL LEGAL EDUCATION’S (CLE) EXPERIENCE IN UNIVERSITI SAINS ISLAM MALAYSIA
Authors: Che Musa Norsuhaida , Nawi Nor Fadzlina
Published: June 2021

Various research has given valuable insights into the positive role of Clinical Legal Education (CLE). However, there is a dearth of empirical data reviewing the set-up of CLE in public law schools in Malaysia and assessing its role as a teaching and learning strategy in legal education. This paper summarises the development and structure of the Faculty of Syariah and Law's Legal Clinic pilot initiative at the Universiti Sains Islam Malaysia (USIM). It assesses the impacts of the initiative on students' learning experience. The assessment involved a content analysis of written feedback given by a batch of pioneer students selected to join the FSU Legal Clinics pilot project in 2019. The findings indicated that the students believe exposure to the legal clinic increases their comprehension of the law's application and provides awareness of the professional skills and values involved in the legal profession. The sample is small, and the findings are preliminary. However, it is hoped that the results will inform legal curriculum developers of the benefits that law students derived from their clinical experience and provide a basis for further research into formally including clinical legal education in the FSU legal curriculum. This paper also advocates that although setting up, planning and organising activities for a successful legal clinic involved a great deal of preparation, it would benefit students and be integral to teaching and learning strategy in legal education in FSU USIM.
Şah İsmail Dönemi Safevî-Portekiz Siyasi İlişkileri
Authors: HAZRATİ Hasan , NAMLI Adem
Published: June 2021

Avrupalı devletlerin Doğu devletleri ile siyasi ve iktisadi çıkarları için ittifak kurma çabaları Akkoyunlulara hatta İlhanlılara kadar uzanmaktadır. Osmanlı Devleti’nin ilerleyişini durdurmak isteyen Venedik ve Trabzon Rum İmparatorluğu Akkoyunlu Devleti Hükümdarı Uzun Hasan’a elçiler göndermiş ve Osmanlı’ya karşı ittifak teklifinde bulunmuşlardır. XVI. yüzyıla gelindiğinde yine aynı politikanın devam ettiği görülmektedir. Bu yüzyılın başında kurulan Safevî Devleti, Avrupalı devletlerin Osmanlı karşısında ittifak yapabilecekleri siyasi ve ticari çıkarlar elde edebilecekleri stratejik bir konuma sahipti. Safevî Devleti’nin hem coğrafi konumu hem Şii mezhebini devletin resmi dini olarak kabul etmesi Osmanlı Devleti’ni kıskaca almak isteyen Avrupalı devletler için eşsiz bir fırsat sunmuştur. Aynı şekilde etrafını çevreleyen Sünni Müslüman devletler arasında sıkışan ve İslam’ın liderliği iddiasında bulunan Şii Safevî Devleti için Avrupalı devletlerle ilişki kurmak kaçınılmaz olmuştur. Safevî Devleti’nin mezhebi, siyasi ve iktisadi bakımdan en büyük rakibi olarak gördüğü Osmanlı Devleti’ne karşı tek başına mücadele etmesi mümkün değildi. Osmanlı Devleti’ne karşı üstünlük elde etmeye çalışan Safevî Devleti, bu gerçeklik doğrultusunda emperyalist hedeflerle İran sularına gelen Portekiz ile iş birliği yapmayı bir strateji olarak belirlemiştir. Bu makalede tamamıyla Farsça kaynaklar dikkate alınarak Safevî Devleti’nin siyasi ve iktisadi çıkarları için Portekiz ile ilişki kurmasını başlatan süreç, Safevî Devleti’nin takip ettiği strateji ele alınırken aynı zamanda Portekiz’in emperyalist hedeflerle hareket ederek bölge devletlerine karşı uyguladığı politika gözler önüne serilmeye çalışılmıştır.
Başlangıcından Günümüze Şiî Politik Düşüncesi
Authors: KABULANTOK Nursima
Published: June 2021

Bu çalışmada Mazlum Uyar’ın “Başlangıcından Günümüze Şiî Politik Düşüncesi” adlı eseri tanıtılmaya çalışılmıştır. Eserde, nass ile tayin edilen imamın siyasî makamını işgal eden bütün idarecileri “gâsıp ve zâlim” olarak nitelendiren Şiî-İmâmî ulemâyı, 1979’da İran İslam Cumhuriyeti’nin kuruluşuyla bizzat “velâyet-i fakîh” noktasına taşıyan sürecin izi sürülmektedir. Müellif, Şiî-usûlî ulemânın yaptığı yorumlarla yetki alanını genişletme sürecini eleştirel bir tarzda aktarmaktadır. Humeynî, İran İslâm Devrimi ve velâyet-i fakîh doktrini hakkında birçok akademik çalışma yapılmıştır. Uyar’ın bu eseri de alana, ulemâ-umerâ ilişkisi açısından katkı sağlayacaktır.
Система комплексного еко-енерго-економічного моніторингу для оптимізації управлінських рішень (області, району та міста)
Authors: Сліпченко В.Г. , Полягушко Л.Г. , Круш О.Є.
Published: June 2021

У статті розглянуто питання розробки системи комплексного еко-енерго-економічного моніторингу для ефективного прийняття управлінських рішень для забезпечення високої якості життя та здоров’я населення. Система дозволяє проводити моніторинг області, району та міста експертами різного профілю, а саме, еколог, енергетик, економіст, лікар, юрист та аналітик. Такий набір експертів охоплює всі важливі аспекти екологічного, економічного та соціального розвитку населення. Запропонована модульна архітектура системи є універсальною та легкою для модернізації, при додаванні нових функціональних можливостей не вимагає перероблення усього комплексу, а лише одного модуля – розрахункового, інші модулі потребують мінімальних змін або взагалі не змінюються.Отримані результати знайшли своє практичне та наукове застосування під час проведення наукових досліджень та підготовки спеціалістів по комп’ютерним наукам та інформаційним технологіям, а також фахівців по екологічній безпеці.
Modeling of the electric drive of the main motion of the rolling cage as a multi-mass electromechanical system
Authors: Шевченко І.С. , Руднєв Є.С. , Романченко Ю.А.
Published: June 2021

The model of rolling stand of a thick-plate rolling mill 3000 has been designed in the work in order to determine the oscillations frequencies that occur during operation, the effect of their amplitude on the dynamic deviations of the speed of the working body from the specified one.Presented results of the research dynamic to rolling cage 3000 at presentation her as seven masses electromechanic system. Shown influence clearance in mechanical issue on dynamic of the mechanism.The research by the method of mathematical modeling in the design and operation of mechanical equipment is substantiated.The design diagram of mechanical part of the electromechanical system is presented.Using the simulation results it was confirmed that the influence of internal viscous friction in shafting on the oscillation damping is not significant in relation to the damping properties of electric drive.Therefore, in the first approximation, it can be ignored. The electric drive of the rolling stand was considered as a TP-D system with speed and current regulators at their standard settings to the modular optimum. To reduce the magnitude of the elastic moments in the kinematic chain of the stand the armature current intensity generator in the electric drive is used.Simulation of the processes was carried out in Simulink of the MATLAB package.Thestand model is designed according to design scheme and reflects the branching into two channels with their combination through an elastic element – the material that is rolled.Based on real geometry and taking into account the properties of material the stiffness of shafts of mechanical transmissions were calculated.The model was set to a rolling program with a variable speed – in order to compensate the thickness difference, which corresponds to modern technological trends.Comparing the simulation results, it was found that the presence of a gap provokes the appearance of self-oscillations, the damping of which in a real mechanical system will occur due to damping properties of the shafts.The damping of oscillations takes place due to the damping properties of the electric drive. The appearance of a gap in the spindles leads to an increase in the system vibration frequency (70-80 Hz).
State and regional policy on industrial waste management: the EU experience for Ukraine
Authors: Pokataiev P , Garkavyy I , Koltun V , Shamrai N , Kramarenko K
Published: June 2021

Purpose. To identify the main trends caused by the divergence of the policy of Ukraine and the EU in the formation and accumulation of waste and threats to the environment. Methodology. Using the methods of content analysis, quantitative and qualitative comparison, EU policy on waste management is analyzed and logical generalization is used to establish the features of waste management financing for industries and regions. Findings. Regional irregularities of industrial waste accumulation, including hazardous waste, trends of their change are revealed. The reasons for regional peculiarities of waste management in the EU and Ukraine are established. It is established that the distribution of capital investments both in environmental protection in general and in waste management in particular does not always coincide with the leading regions of accumulation. It is established that limitation of financial instruments for waste management only by budgetary resources leads to a reduction in capital investment. A comparison of trends in environmental spending and waste management indicated a significant difference. Analysis of environmental investment by polluting industries, which are unevenly represented in different regions, revealed a significant difference between them. Originality. Regions that are the main polluters have been identified. The discrepancy between trends of capital investments in environmental protection and waste management was revealed. It is established that the list of leading regions in terms of capital investments in environmental protection does not correlate with the list of leading regions of waste accumulation. It is pointed out that uneven investment creates risks of increasing the rate of waste accumulation, in particular hazardous waste. Forecasting of indicators of waste management of the following periods is carried out. Practical value. There are risks of increasing the rate of waste accumulation, especially hazardous waste, both in Ukraine in general and in some regions, inequalities in some areas in the amount of capital investment into environmental protection, which will form an effective waste management policy. Identifying common features and differences in waste management in the EU and Ukraine will allow implementing effective environmental protection tools, reducing risks in industrial waste management.
Evaluation of ultrasonic cleaning process
Authors: Morkun V , Kravchenko O
Published: June 2021

Purpose. To establish relationship between intensity of ultrasonic cleaning and an ultrasonic response fixed at a set point. To determine the influence of liquid contamination on this signal. To specify parameters of an ultrasonic signal to evaluate the course of cleaning a preset section of a body. To define limiting values indicating efficiency of ceasing the cleaning process. Methodology. The research is based on simulation of ultrasonic wave propagation in the heterogeneous environment and subsequent analysis of the signals by using software. Findings. Dependences are established to form evaluation of the course of the cleaning process by parameters of the ultrasonic response. It is found that both the bodys state and that of the liquid affect the ultrasonic response obtained by the sensor at the set point during ultrasonic cleaning. With high contamination (>30%) the state of the liquid becomes a critical factor for forming the signal of the ultrasonic response. With that, there is an abrupt reduction of threshold signal arrival time and increase in the main amplitude, which is to be one of indicators of ceasing the cleaning process in case of its inefficiency. With lower contamination, suspended contaminant particles only correct the signal to some extent without distorting it. There is a relationship between reduction of contamination, the arrival time of threshold signal, on the one hand, and the value of the main amplitude and the 2nd and 3rd-order nonlinearity coefficients, on the other hand. The arrival of the threshold value of the signal is the major parameter determining intensity of cleaning, i.e. reduction of contaminant thickness, which is determined by the value of the main amplitude of the signal and the 2nd and 3rd-order nonlinearity coefficients. Originality. For the first time, methods for evaluating the course of the ultrasonic cleaning process by analyzing ultrasonic responses at a specified point have been developed. Practical value. To consider spatial distribution of the ultrasonic cleaning process, its control is to be based on evaluating the bodys contamination in several preset points. To implement this, the character of dependences between changes in contamination of the body section and parameters of the fixed ultrasonic response is determined. Impacts are considered of suspended contaminant particles in the liquid on the signal analyzed. The observed relationship will provide the basis for building the spatially distributed control over ultrasonic cleaning considering the cleaned bodys state.
Organizational culture in cooperation of business and education in Ukraine
Authors: Tepliuk M , Shkoda T , Kukoba V , Chebakova T , Petrovska S
Published: June 2021

Purpose. To improve a method of organizational culture assessment for making management decisions in cooperation of business and education. Methodology. The study is based on the data of the leading enterprises producing plastics in Ukraine over the period of 20152019. Through the method of binary logic for the purposes of assessing the proposed components of organizational culture of enterprises (intellectual, technical-technological, social, legal and regulatory, professional, communicative, informational), the levels of this culture in plastics manufacturers are determined in mathematical terms. Findings. Based on the generalization of the results of theoretical research on the economic essence of the organizational culture of the enterprise, its key components and the main parameters characterizing them are identified. Public JSC Ukrplastic is identified as the leading company producing plastic products in Ukraine with the highest performance in organizational culture by individual components of the enterprise. The other analyzed companies have medium level of organizational culture indicators. Originality. The research is conducive to the studies on organizational culture, especially the perspective of its usage as a tool of cooperation between Ukrainian plastic producers as the business representatives and educational sector. Practical value. The results of the study can be used by practitioners, scientists, government officials (Ministry of Education and Science of Ukraine and its structural departments, local governments in the fields of education and science) to monitor the development of the information economy.
La construcción del conocimiento de la Educación Inclusiva
Authors: Ocampo González Aldo
Published: June 2021

Este artículo explora los mecanismos de construcción del conocimiento de la educación inclusiva. La inclusión no se limita a ningún campo en específico, no así, la educación inclusiva. Lo inclusivo en el mundo contemporáneo desborda los significantes canónicos sobre los que se erige la función edipizante del calificativo a la fuerza subordinante, dominadora y normativa de lo especial. Nada comparte en su genealógica, función, alcance y naturaleza la educación inclusiva con la educación especial, si este error de proximidad objetual ha sido establecido, se debe, en parte, a la incapacidad de comprender la diversidad de objetos que en él participan, así como, las debilidades de comprensión del término. El trabajo analiza las designaciones que impone su naturaleza epistemológica ‘post-disciplinar’  traza un signo supra-disciplinar y una fuerza generadora de orden diaspórica y nomadista, mecanismos sustentados en lo no-lineal –manifestación incardinada en lo rizomático–, la des-familiarización y producción de otros recursos heurísticos. El trabajo concluye analizando que la educación inclusiva construye una epistemología neo-materialista, una afirmación crítica con el presente.
Manejo sostenible de residuos sólidos domiciliarios: recolección y transporte al relleno sanitario. Caso cantón Naranjal
Authors: Araujo Antonio , Delgado Omar
Published: June 2021

Las rutas de recolección de residuos sólidos domiciliarios en el cantón Naranjal se han creado de manera intuitiva y no responden a un análisis técnico. En este estudio se evaluó las rutas actuales de recolección y se diseñó nuevas rutas optimizadas, mediante el uso de Sistema de Información Geográfica (SIG), con la finalidad de minimizar la distancia recorrida y aumentar la cobertura de recolección. Para la optimización de las rutas se utilizó el software ArcGis 10.3 y se aplicó la herramienta Network Analyst. Los resultados de la investigación permitieron reducir las rutas de 24 existentes a 20 rutas de recolección diferenciadas (10 en la cabecera cantonal y 10 en el área rural de Naranjal), se aumentó la cobertura de recolección e incrementó la frecuencia en el área rural.

Palabras clave: Recolección de desechos, residuos sólidos domiciliarios (RSD), optimización de rutas, ArcGis10.3, Network Analyst.

AbstractIn Naranjal, domestic solid waste collection routes have been created intuitively and do not respond to a technical analysis. The present study evaluated the current collection routes to design new optimized routes, through the use of Geographic Information Systems (GIS), in order to minimize the distance traveled and increase collection coverage. ArcGis 10.3 software was used for route optimization and the Network Analyst tool was applied. The results of the research made it possible to reduce the existing routes from 24 to 20 diferentiated collection routes (10 in the cantonal head and 10 in the rural area of Naranjal) increasing the collection coverage and the frequency in the rural area was also increased.

Keywords: waste collection, domestic solid waste (DSW), route optimization, ArcGis 10.3, Network Analyst.
Perlakuan Akuntansi Zakat sebagai Salah Satu Elemen dalam Laporan Keuangan: Suatu Introduksi Akuntansi Baru dalam Financial Statement
Authors: Budiman Ahmad
Published: June 2021

Zakat merupakan salah satu rukun Islam, bahkan merupakan rukun kemasyarakatan yang paling tampak di antara sekian rukun-rukun Islam. Banyak upaya yang dilakukan oleh masyarakat untuk meningkatkan peran zakat, yang salah satunya melalui pendirian BAZIS. BAZIS melaporkan dana zakat yang dihimpun dari masyarakat setiap tahun sebagai bentuk pertanggungjawaban kepada muzakki, munfiq, mushaddiq, dewan penasihat, dan Allah SWT, akan tetapi banyak laporan keuangan yang diterbitkan oleh BAZIS yang masih kurang sesuai dengan ketetapan syariah Islam. Berdasarkan berbagai kekurangan yang telah ada, maka solusi pelaporan atas laporan keuangan LAZIS Masjid Raden Patah Universitas Brawijaya  seharusnya berupa neraca,  Zakat Funds Statement, dan Infaq and Shadaqah Funds Statement sebagai pengganti laporan laba rugi serta laporan perubahan modal.
Interpretasi Agama, Budaya Organisasi dan Individualisme terhadap Etos Kerja Muslim: Studi pada Rumah Sakit Islam Gondanglegi
Authors: Munawir Munawir
Published: June 2021

Penelitian ini bertujuan untuk melihat apakah pengaruh interpretasi agama (Islam), budaya organisasi dan individualism berpengaruh pada kualitas etos kerja muslim. Berdasarkan hasil analisis, maka dapat ditarik kesimpulan sebagai jawaban atas permasalahan dan tujuan yang telah ditetapkan: Berdasarkan hasil analisis regresi parsial dihasilkan temuan jika ketiga variabel bebas secara sendiri-sendiri (parsial) tidak berpengaruh signifikan terhadap etos kerja Muslim. Berdasarkan hasil uji analisis regresi diketahui jika variabel bebas yang mempunyai pengaruh dominan pada etos kerja Muslim adalah variabel bebas budaya organisasi. Namun, dengan besarnya pengaruh semua variabel bebas yang tidak sampai satu persen (0,8%), maka dominasi variabel budaya organisasi tidaklah berpengaruh. Etos kerja Islam tidaklah serendah pandangan para peneliti etos kerja terdahulu, khususnya dalam usaha membandingkan dengan etos kerja Protestan. Etos kerja Islam juga menekankan perlunya suatu perubahan, ditandai dengan tingginya respons terhadap indikator-indikator yang merupakan unsur-unsur penting dalam suatu perubahan seperti kedisiplinan, jiwa wiraswasta, semangat belajar dan kreativitas.
Prevenzione delle infezioni catetere venoso centrale correlate (CRBSI)
Authors: Cornacchiari Marina , Gallieni Maurizio , Stasi Antonella , Ponticelli Maria Giuseppina , Gidaro Barbara , Guastoni Carlo
Published: June 2021

L'uso dei cateteri venosi centrali (CVC) temporanei o permanenti è in costante aumento tra i pazienti emodializzati, ma questi dispositivi sono gravati da numerose complicanze, potenzialmente anche gravi. Tra queste, sicuramente le infezioni sono quelle con un maggiore impatto su morbilità e mortalità. Le infezioni correlate al CVC possono interessare il sito di emergenza del catetere e il tratto sottocutaneo dei cateteri tunnellizzati o, nei casi più gravi, possono determinare batteriemie e/o setticemie (CRBSI, catheter related blood-stream infections). Importante è la loro prevenzione attraverso l'educazione del personale sanitario che gestisce tali dispositivi, associata a un buon protocollo di utilizzo degli stessi. Infatti, è dimostrato che, con un adeguato protocollo di inserimento e di gestione dei CVC, le CRBSI possono essere significativamente ridotte, al di sotto di 1 episodio ogni 1000 giorni-catetere.
Kaji Banding Pertumbuhan dan Kadar Hara N,P dan K Tanaman Jagung (Zea mays L). pada Tiga Macam Pupuk Organik Berbeda Kualitas
Authors: Romadhoni M.Rizky , Sholihah Anis , Nurhidayati N.
Published: June 2021

Jagung (Zea mays L.) merupakan komoditas tanaman pangan yang berperan penting dan strategis dalam pembangunan nasional. Penelitian ini bertujuan untuk mengetahui pertumbuhan dan kadar hara N,P,K akibat interaksi macam pupuk organik dengan dosis aplikasinya. Penelitian ini merupakan percobaan pot yang menggunakan Rancangan Acak Kelompok (RAK) Faktorial dengan Kontrol, faktor pertama adalah macam pupuk organik (vermikompos, pupuk kotoran sapi dan kompos seresah daun bambu) dan faktor kedua adalah dosis aplikasinya (5, 10, 15 dan 20 ton.ha-1).  Dari dua faktor tersebut diperoleh 12 kombinasi perlakuan dan ditambah satu perlakuan kontrol. Tiap-tiap perlakuan diulang 3 kali. Ada dua variabel pengamatan yang dilakukan yaitu variabel tumbuh dan variabel kadar hara. Data yang diamati dianalisis dengan uji F pada taraf 5%. Jika terdapat pengaruh nyata maka dilanjut dengan uji BNJ 5% dan uji Dunnet pada taraf 5%. Dilakukan uji regresi untuk menentukan dosis optimum masing-masing pupuk organik. Hasil penelitian menunjukkan bahwa pertumbuhan tanaman terbaik adalah aplikasi vermikompos dengan dosis 15-20 ton.ha-1 dan pupuk kotoran sapi 10-20 ton.ha-1. Sedangkan perlakuan yang memberikan kadar hara tertinggi adalah aplikasi vermikompos dengan dosis 20 ton.ha-1. Keywords: Jagung, Vermikompos, Pupuk Kotoran Sapi, Kompos Daun Bambu
Pengaruh Macam Komposisi Media Tanam dan Dosis Vermikompos Cair terhadap Pertumbuhan dan Hasil Tanaman Selada ( Lactuca sativa L.) Secara Hidroganik
Authors: Aziz Muhammad Fikri , Murwani Indiyah , Nurhidayati N
Published: June 2021

With decreasing the area of productive agricultural land, soilless cultivation is greatly needed to develop healthier vegetables cultivation. This study aimed to determine the effect of the kind of composition of the growing medium and liquid vermicompost dosage on the growth and yield of lettuce (Lactuca sativa L.) which growing hidroganically. This study was a pot experiment using Factorial Randomized Block Design (RBD). The first factor was the kind of media composition consisting of two levels, namely: M1 = cocopeat (55%), zeolite (15%), and sand (30%), M2 = cocopeat (55%), zeolite (30%), sand 0.14 (15%). The second factor was vermicompost dosage consisting of five levels: V1 = 50 g/pot, V2 = 100 g/pot, V3 = 150 g/pot, V4 = 200 g/pot, V5 = 250 g/pot. Each treatment had thre replications with five plants samples. The results showed that the two factors tested did not show significant interaction. Separately, the kinds of media composition did not have a significant effect. While the treatment of vermicompost dosages had a significant effect, where  overall the dosage of V4-V5 (200-250 g/pot) gave the highest yield of lettuce. The average fresh weight of total biomass at these doses ranged from 158.92-163.33 g/plant. Keywords: Composition of growing media, Lettuce, Hydroganic, Vermicompost
PENGARUH METODE DAN DOSIS APLIKASI VERMIKOMPOS TERHADAP PERTUMBUHAN DAN HASIL TANAMAN TOMAT (Lycopersicum Esculentum Miil) HIDROGANIK
Authors: Filardi Ahmad , Djuhari D , Nurhidayati N
Published: June 2021

The soilless culture system now developed rapidly in line with the decrease of the area ofproductive farmland as well as to meet healthy food needs and nutritious high. Thisresearch developed a soilles culture by using vermicompost organic fertilizers.This studyaimed to test influence of application methods and doses vermicompost on the growthand yield of tomato grown in hidroganic system. This experiment used a FactorialRandomized Block Design. The first factor : application methods of vermicompostconsisting of three levels namely M1 = solid vermicompost, M2 = combination of solid andliquid vermicompost, M3 = liquid vermicompost. The second factor : doses ofvermicompost consisting of five levels namely V1 = 150 grams, V2 = 300 grams , V3 = 450grams , V4 = 600 grams and V5 = 750 grams per polibag, plus control treatment usinginorganic fertilizer. The research results showed that interaction between applicationmethods and vermicompost doses had a significant effect on the growth and yield oftomato plants. The best combination of treatment was solid vermicompost at a dose of600 g/polybag gave a growth of plant height of 78.50 cm, leaf number of 205.33, leaf area of 4516.75 cm2 and flower number 24.78. This treatment had the best yield parametersby the fruit number of 24,33, fruit set of 98,20% and total weight of fruit 447,22 g/plant.Based on the regresion analysis showed that the optimum dose of vermicompost for solidvermicompost was 709.50 g/plant and the maximum yield was 494.70 g/plant. This resultsuggests that the solid vermicompost application can be recommended for hidroganicculture of tomato.Keyword : Tomato, Soilless Culture, Vermicompost, Growth, Yield
PENGARUH PEMBERIAN PROBIOTIK Bacillus subtilis DAN Saccharomyces cerevisiae PADA PRODUKSI LAYER UMUR 24 MINGGU
Authors: Saputro Nanang Agus , Lisnanti E. F. , Rudiono D.
Published: June 2021

700 ekor Isa Brown digunakan untuk menentukan efek dari bakteri  Bacillus subtilis dan Saccharomyces cerevisiae yang 'siap dicampur dalam bentuk probiotik pakan' untuk menghasilkan kinerja pada layer usia 24 minggu. Evaluasi dilakukan selama 4 minggu di kandang Bapak Kholil, yang terletak di Kecamatan Kademangan Desa Dawuhan, Kabupaten Blitar. Perlakuan pakan dibagi menjadi dua kelompok, yaitu: PO (45% jagung + 13,5% merek beras + 7% tepung tulang daging + 23% tepung kedelai + 1,5% premix + 1% tepung batu) dan P1 ( 45% jagung + 13,5% merek beras + 7% tepung tulang daging + 23% tepung kedelai + 1,5% premix + 1% tepung batu + 0,1 probiotik); untuk analisis menggunakan uji t. Parameter dimasukkan: Konsumsi Pakan (g / ekor / hari); FCR; berat telur (g); Produksi Hen Day (%); Massa Telur (g); dan Penghasilan dari Biaya Pakan (Rp / hari). Hasil penelitian menunjukkan bahwa tidak ada pengaruh yang signifikan (P> 0,05) pada konsumsi pakan (103,52 vs 103,66 g / ayam), berat telur (56,94 vs 57,57 g / telur), namun, ada pengaruh yang signifikan (P <0,05) pada ayam produksi hari (36,45 vs 47,42%), massa telur (20,78 vs 2,29 g), rasio konversi pakan (6,28 vs 4,40), pendapatan atas biaya pakan masing-masing (-121,96 vs -8, Rp. 72 / ayam). Kesimpulan   dari penelitian   ini   adalah   penambahan   bakteri   Bacillus   subtilis   dan Saccharomyces cerevisiae ke dalam pakan sendiri dapat mempengaruhi konsumsi pakan, produksi hari ayam, tingkat konversi pakan dan pendapatan dari biaya pakan untuk ayam petelur pada 24 minggu usia, tetapi tidak berpengaruh pada berat telur.
FREKUENSI PENYIRAMAN PUPUK ORGANIK CAIR TERHADAP PERSENTASE PERKECAMBAHAN DAN PERSENTASE KECAMBAH NORMAL HIDROPONIK FODDER GANDUM
Authors: Kustyorini Tri Ida Wahyu , Puriastuti Dimas Pratidina , Bandung Febronius
Published: June 2021

Tujuan penelitian ini adalah untuk mengetahui pengaruh frekuensi penyiraman pupuk organik cair terhadap persentase perkecambahan dan persentase kecambah normal  hidroponik fodder gandum. Materi yang digunakan dalam penelitian ini adalah biji gandum, POC dan air. Metode penelitian yang digunakan adalah percobaan lapang dengan menggunakan rancangan acak lengkap ( RAL ). Perlakuan penelitian yaitu frekuensi penyiraman dengan pupuk organik cair 10% dengan volume 100 ml/hari yaitu P1 : penyiraman 1 kali/sehari, P2 : Penyiraman 2 kali/sehari, P3 : Penyiraman 3 kali/sehari. Masing-masing perlakuan diulang sebanyak 5 kali. Variabel penelitian meliputi persentase perkecambahan dan persentase kecambah normal. Analisis statistik yang digunakan  adalah analisis varians. Jika terdapat pengaruh antar perlakuan, maka dilanjut dengan uji BNT. Berdasarkan hasil penelitian menunjukkan bahwa frekuensi penyiraman dengan menggunakan pupuk organik cair memberikan pengaruh yang sangat nyata (P< 0,01 ) terhadap persentase perkecambahan dan persentase kecambah normal. Nilai tertinggi persentase perkecambahan dan persentase kecambah normal dicapai pada perlakuan P2 yakni 87,11% dan 92,85%. Berdasarkan hasil penelitian dapat disimpulkan bahwa frekuensi penyiraman 2 kali sehari dengan pupuk organik cair memberikan hasil terbaik terhadap produktivitas fodder gandum dengan sistem hidroponik.
A Formação Continuada de Professores na perspectiva dos Conhecimentos Didáticos Matemáticos
Authors: Carpes Patricia Pujol Goulart , Bisognin Eleni
Published: June 2021

O presente estudo visa identificar e analisar as possíveis contribuições do sistema modular Conhecimentos Didáticos Matemáticos (CDM) em um curso formativo e investigativo com professores de Matemática. Para tal, organizou-se um curso na perspectiva do CDM para o ensino de números racionais no Ensino Fundamental. A pesquisa, de base qualitativa, teve seus dados analisados a partir do Guia de Avaliação da Idoneidade Didática de Processos de Instrução em Educação Matemática. Esse guia fornece componentes e indicadores para analisar e avaliar cursos de formação de professores por meio das dimensões do CDM. As atividades do curso foram construídas, desenvolvidas e registradas por meio de portfólios individuais e socializadas entre o grupo. Ao analisa-los aponta-se que serviram para orientar e organizar as atividades além de propiciar a reflexão sobre os conhecimentos mobilizados, principalmente epistêmicos e cognitivos.
Subcellular redistribution of trimeric G-proteins – potential mechanism of desensitization of hormone response; internalisation, solubilization, down-regulation
Authors: Drastichová Z , Bouřová L , Lisý V , Hejnová L , Rudajev V , Stohr J , Durchánková D , Ostašov P , Teisinger J , Soukup T , Novotný J , Svoboda P
Published: June 2021

Agonist-induced subcellular redistribution of G-protein coupled receptors (GPCR) and of trimeric guanine-nucleotide binding regulatory proteins (G-proteins) represent mechanisms of desensitization of hormone response, which have been studied in our laboratory since 1989. This review brings a short summary of these results and also presents information about related literature data covering at least small part of research carried out in this area. We have also mentioned sodium plus potassium dependent adenosine triphosphatase (Na, K-ATPase) and 3H-ouabain binding as useful reference standard of plasma membrane purity in the brain.
14-3-3 proteins: a family of versatile molecular regulators
Authors: Obšilová V , Šilhan J , Bouřa E , Teisinger J , Obšil T
Published: June 2021

The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase.
The role of spinal cord vanilloid (TRPV1) receptors in pain modulation
Authors: Špicarová D , Paleček J
Published: June 2021

Transient receptor potential vanilloid 1 (TRPV1) receptor is a nonselective cation channel activated by capsaicin, a pungent substance from chili peppers. It is considered to act as an integrator of various physical and chemical nociceptive stimuli, as it can be gated by noxious heat (>43 oC), low pH (protons) and also by recently described endogenous lipids. The structure and function of TRPV1 receptors was vigorously studied, especially since its cloning in 1997. However, most of the research was pointed towards the role of TRPV1 receptors in the peripheral tissues. Mounting evidence now suggests that TRPV1 receptors on the central branches of dorsal root ganglion neurons in the spinal cord may play an important role in modulation of pain and nociceptive transmission. The aim of this short review was to summarize the knowledge about TRPV1 receptors in the spinal cord dorsal horn, preferentially from morphological and electrophysiological studies on spinal cord slices and from in vivo experiments.
What is the role of neurotransmitter systems in cortical seizures?
Authors: Mareš P , Kubová H
Published: June 2021

Epileptic afterdischarges (ADs) elicited by electrical stimulation of sensorimotor cortical area were used as a model to study the role of neurotransmitter systems in cortical seizures in three age groups of developing rats. Drugs augmenting inhibition mediated by GABAA receptors were found to suppress ADs in all age groups, their activity was usually more marked in younger than in 25-day-old rat pups. Drugs potentiating GABAB receptors exhibit lower efficacy and more complicated developmental profile than GABAA-ergic drugs. Effects of an antagonist of GABAB receptor--marked prolongation of ADs in all three age groups--suggest an important role of GABAB receptors in arrest of cortical seizures. Drugs affecting glutamate receptors exhibit variable effects, usually better expressed in older animals than in 12-day-old ones. No specific role for ionotropic as well as metabotropic glutamate receptors could be predicted. Activation of adenosinergic inhibitory modulatory system also exhibited anticonvulsant action in the present model. All three neurotransmitter systems probably participate in mechanisms of generation, maintenance and arrest of cortical seizures.
Sosyal Bilimler Makale Özetlerinin Sözbilimsel Yapısı
Authors: ŞEN Ekin
Published: June 2021

Makale özetleri alanyazında makalenin tanıtılması ve okurları ana metni okumaya ikna etme işlevlerine sahip bir metin türü olarak tanımlanmaktadır. Bu çalışmanın amacı sosyal bilimler altında yer alan felsefe, psikoloji ve tarih alanlarındaki makale özetlerinde kullanılan sözbilimsel yapılanmayı belirlemek ve sosyal bilimler altındaki alanlar arasında bir karşılaştırma yapmaktır. Bu amaç için 2013-2017 yılları arasında bilimsel dergilerde Türkçe yayınlanmış makalelerin Türkçe özetlerinden her bir alandan 50 olmak üzere toplamda 150 metinden oluşan bir veritabanı oluşturulmuş ve bu veri tabanındaki özetler Hyland’ın (2004) alanyazına kazandırdığı makale özeti hamle sınıflandırmasına göre sınıflandırılmıştır. Çalışmada ortaya çıkan bulgular felsefe ve tarih özetlerinde giriş ve amaç (G ve A) hamlelerine yönelik bir eğilimi, psikoloji özetlerinde ise amaç, yöntem, bulgu ve sonuç (A-Y-B-S) hamleleri gibi makalenin temel bölümlerine gönderimde bulunan hamlelere yönelik bir eğilimi ortaya koymuştur. Bu bulgular ışığında sosyal bilimler altındaki alanların makale özeti oluştururken farklı motivasyonlara sahip olduğu, olası okurları için farklı türden bilgileri öncelediği, dolayısıyla okurlarını ana metni okumaya yönlendirme konusuna farklı bakış açılarıyla yaklaştıkları söylenebilir.
A Functional Variant Rs492554 Associated With Congenital Heart Defects Modulates SESN2 Expression Through POU2F1
Authors: Yang Wenke , Li Yi , Bai Jun , You Tao , Yi Kang , Xie Dingxiong , Zhang Xiaowei , Xie Xiaodong
Published: June 2021

Hypoxia exposure is responsible for the high incidence of congenital heart defects (CHDs) in high-altitude areas, which is nearly 20 times higher than that in low-altitude areas. However, the genetic factors involved are rarely reported. Sestrin2 (SESN2), a hypoxia stress-inducible gene, protects cardiomyocyte viability under stress; thus, SESN2 polymorphism may be a potential risk factor for CHD. We performed an association study of the SESN2 polymorphisms with CHD risk in two independent groups of the Han Chinese population from two different altitude areas. The allele-specific effects of lead single-nucleotide polymorphisms (SNPs) were assessed by expression quantitative trait locus, electrophoretic mobility shift, and luciferase reporter assays. The molecular mechanism of Sesn2 action against hypoxia-induced cell injury was investigated in embryonic rat-heart-derived H9c2 cells treated with or without hypoxia-mimetic cobalt chloride. SNP rs492554 was significantly associated with reduced CHD risk in the high-altitude population, but not in the low-altitude population. The protective T allele of rs492554 was correlated with higher SESN2 expression and showed a preferential binding affinity to POU2F1. We then identified SNP rs12406992 in strong linkage disequilibrium with rs492554 and mapped it within the binding motif of POU2F1. The T-C haplotype of rs492554-rs12406992 could increase luciferase expression, whereas POU2F1 knockdown effectively suppressed it. Mechanistically, increased Sesn2 protects against oxidative stress and cell apoptosis and maintains cell viability and proliferation. In summary, CHD-associated SNP rs492554 acts as an allele-specific distal enhancer to modulate SESN2 expression via interaction with POU2F1, which might provide new mechanistic insights into CHD pathogenesis.
Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks
Authors: Urrutia Guillermo , de Assuncao Thiago Milech , Mathison Angela J. , Salmonson Ann , Kerketta Romica , Zeighami Atefeh , Stodola Timothy J. , Adsay Volkan , Pehlivanoglu Burcin , Dwinell Michael B. , Zimmermann Michael T. , Iovanna Juan L. , Urrutia Raul , Lomberk Gwen
Published: June 2021

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, painful disease with a 5-year survival rate of only 9%. Recent evidence indicates that distinct epigenomic landscapes underlie PDAC progression, identifying the H3K9me pathway as important to its pathobiology. Here, we delineate the role of Euchromatic Histone-lysine N-Methyltransferase 2 (EHMT2), the enzyme that generates H3K9me, as a downstream effector of oncogenic KRAS during PDAC initiation and pancreatitis-associated promotion. EHMT2 inactivation in pancreatic cells reduces H3K9me2 and antagonizes KrasG12D-mediated acinar-to-ductal metaplasia (ADM) and Pancreatic Intraepithelial Neoplasia (PanIN) formation in both the Pdx1-Cre and P48Cre/+KrasG12D mouse models. Ex vivo acinar explants also show impaired EGFR-KRAS-MAPK pathway-mediated ADM upon EHMT2 deletion. Notably, KrasG12D increases EHMT2 protein levels and EHMT2-EHMT1-WIZ complex formation. Transcriptome analysis reveals that EHMT2 inactivation upregulates a cell cycle inhibitory gene expression network that converges on the Cdkn1a/p21-Chek2 pathway. Congruently, pancreas tissue from KrasG12D animals with EHMT2 inactivation have increased P21 protein levels and enhanced senescence. Furthermore, loss of EHMT2 reduces inflammatory cell infiltration typically induced during KrasG12D-mediated initiation. The inhibitory effect on KrasG12D-induced growth is maintained in the pancreatitis-accelerated model, while simultaneously modifying immunoregulatory gene networks that also contribute to carcinogenesis. This study outlines the existence of a novel KRAS-EHMT2 pathway that is critical for mediating the growth-promoting and immunoregulatory effects of this oncogene in vivo, extending human observations to support a pathophysiological role for the H3K9me pathway in PDAC.