bluuebunny/crossref_metadata_2025 huggingface dataset:
In-chip critical plasma seeds for laser writing of reconfigurable silicon photonics systems
Authors: Grojo David , Wang Andong , Das Amlan , Fedorov Vladimir , Sopeña Pol , Tzortzakis Stelios
Published: July 2024

Ultrafast laser three-dimensional (3D) writing has made breakthrough in manufacturing processes with for instance the advent of super-resolution 3D printing and perennial optical memory technologies. However, similar precision applications were inaccessible for silicon and other semiconductor technologies due to a lack of in-chip controllability of intense infrared beams caused by strong propagation nonlinearities. To solve this problem, plasma-optics concepts are promising since a single ultrashort laser pulse, even if inappropriate for direct writing, can readily inject high-density free-carriers inside semiconductors. To achieve highly localized and reliable processing, we create plasma seeds with tightly focused pre-ionizing femtosecond pulses. We show how critical density conditions can be found under damage threshold inside silicon. This is used for extremely confined energy deposition with a synchronized writing irradiation creating isotropic modifications with sub-diffraction-limit size for the first time. Drastic improvement is also found on the material change controllability leading to unique demonstrations including rewritable optical memories (>100 writing/erasure cycles) and graded-index functionalities. By solving its controllability issues with critical plasma seeds, ultrafast laser writing is poised to offer its full potential for flexible fabrication of reconfigurable monolithic silicon-based devices.
Community knowledge, attitudes, and practices on the use of plants to control mosquitoes: the case of Arjo Gudatu District, East Wollega Zone, Oromia Regional State, Ethiopia
Authors: Tesfaye Lensa , Aklilu Esayas , Tolossa Ketema , Animut Abebe
Published: July 2024

Background
Mosquitoes in the genera Anopheles and Aedes transmit human malaria and several viral diseases, respectively. Insecticide-based mosquito control, most notably indoor residual insecticide spraying and long-lasting insecticide-treated mosquito net use, has been proven to effectively reduce malaria incidence and prevalence. However, its effectiveness is being threatened due to the resistance of its vectors to insecticides. Furthermore, synthetic insecticides have adverse impacts on the environment, ecological balance, and human health. To address these and the increasing threat of mosquito-transmitted diseases, safe, effective, and locally available control strategies are needed.
Objective
The knowledge, attitudes, and practices of the inhabitants of Arjo Gudatu District on the use of plants to control mosquitoes were assessed.
Materials and Method
A descriptive cross-sectional study was carried out among the residents of Mada Jalala, Karsa Dako, and Lalisa Dimtu kebeles (the lowest level of administrative structure) in Arjo Gudatu District, Oromia Regional State, Ethiopia. Households were selected through systematic random sampling and interviewed using a questionnaire developed for this purpose. The data were collected through house-to-house interviews, checked for completeness and consistency, subsequently entered into SPSS version 25, cleaned, and analyzed.
Results
Among the 398 household representatives who participated in the interviews, 63.5% (253/398) perceived that plants are used to control mosquitoes. Approximately 75% (190/253) used plants to control mosquitoes, and 79% (200/253) had good attitudes toward the plants. Plant smoking was the most commonly cited practice for killing and repelling adult mosquitoes. Securidaea longes pedunculate 31/253 (12%) was the most frequently cited plant to have repellent, adulticidal and larvicidal activities, followed by Echinops sphaerocephalus L 28/253 (11%) and Millettia ferruginea (Hochst. ex nees) tender 9/253(3.5).
Conclusion
Millettia ferruginea (Hochst. ex nees) tander, Securidaea longe pedunculate, and Echinops sphaerocephalus L. are the plants most commonly used for the control of mosquitoes. The plants were treated with adulticides, larvicides, and repellents in the traditional control of mosquitoes.
Recent Atlantic overturning inferred from air-sea heat fluxes dominated by decadal variability rather than trend
Authors: Terhaar Jens , Vogt Linus , Foukal Nicholas
Published: July 2024

The evolution of the Atlantic Meridional Overturning Circulation (AMOC) is crucial for global ocean carbon and heat uptake, and controls the climate around the North Atlantic. Despite its importance, quantifying the AMOC’s past changes and assessing its vulnerability to climate change remains highly uncertain. Understanding past AMOC changes has relied on proxies, most notably sea surface temperature anomalies over the subpolar North Atlantic. Here, we use 24 Earth System Models from CMIP6 to demonstrate that these temperature anomalies cannot reconstruct the AMOC. Instead, we find that air-sea heat flux anomalies north of any given latitude in the North Atlantic between 26.5°N and 50°N are tightly linked to the AMOC anomaly at that latitude on decadal and centennial timescales. On these timescales, air-sea heat flux anomalies are strongly linked to AMOC-driven northward heat flux anomalies through the conservation of energy. On annual timescales, however, air-sea heat flux anomalies are mostly altered by atmospheric variability and less by AMOC anomalies. Based on the here identified relationship and observation-based estimates of the past air-sea heat flux in the North Atlantic from reanalysis products, the decadal averaged AMOC at 26.5°N has not weakened from 1963 to 2017 although substantial variability exists at all latitudes.
Regional Industrial Structure Upgrading, Labor Heterogeneity and the Cost of Living in China
Authors: Wang Weijia , Xing Zhengzheng
Published: July 2024

This paper applies Chinese provincial panel data from 2001–2015 to conduct an empirical study to investigate the differential impact of China's regional industrial structure upgrading on labor force heterogeneity by constructing a task-theoretic model, and the results show that regional industrial structure upgrading exhibits a significant growth trend in the demand for the senior labor force, whereas the demand for the intermediate and junior labor force demonstrates a certain negative impact. To further analyze the influence path and take into account regional heterogeneity in China, especially in the eastern coastal region, the cost of living variable is further introduced as a cross-multiplier term for the analysis due to the higher cost of living in the region, and the results show that the increase in the cost of living reduces the overall demand for the labor force, which not only is not conducive to the optimization and upgrading of the local industrial structure but also impedes the sustained development of the economy. Based on this, this study proposes corresponding policy recommendations: by upgrading the education and skill levels of the primary labor force, the demand for labor can be effectively increased, thus solving the structural contradiction of employment in China; at the same time, by lowering the cost of living and providing subsidies for renting or purchasing houses, more talent can be attracted to provide solid human resource support for the upgrading of the regional industrial structure.
Congenital Aortic Arch Abnormality in Tetralogy of Fallot: A Rare Case Report
Authors: Shetty Rakshand , S Madhu C , Uppin Akash , Sachdev Rupali
Published: July 2024

A 4-year-old male child was referred to the paediatrics department of our hospital from an Anganwadi with complaints of easy fatiguability compared to peers, dyspnea on normal exertion and refusal to feed for 10 days. There was no history of palpitation, bluish discolouration, pedal edema, abdominal distention, cough, or orthopnoea. On auscultation, a grade 2 end systolic murmur was heard. Full blood count revealed a Hb 10 g/dl, MCV 67.2 fL, MCH 20.9, and HCT 32.1%. Liver and kidney function tests were within normal limits. However, the Total T3 (2.85 nmol/L) and TSH were elevated (9.30 mmol/L).
Chest X-ray indicated cardiomegaly with right ventricular enlargement with clear lung fields and pleural spaces. ECG further showed right axis deviation and enlargement of the right ventricle. He was diagnosed with Tetralogy of Fallot on 2D Echo, having confluent good-sized pulmonary arteries (Macgoon’s ratio: 1:4), large malaligned VSD with BD shunt, severe valvular and sub-pulmonary annular stenosis. These findings were further confirmed on MDCT Chest with Pulmonary Angiography. Furthermore, Bilateral anomalous origin of both right and left vertebral arteries from the arch of aorta was also observed. Later the patient was scheduled for elective surgical repair. Sauvage patch closure of VSD was done with 5-O continuous prolene sutures followed by reconstruction of the RVOT by augmenting it with a pericardial patch.
The postoperative course was uneventful with minimal drainage. The patient was discharged on Injection Ceftumand Injection Lefoflox with infective endocarditis prophylaxis.
In this case, we aimed to discuss the diagnostic implications of variations in the aortic arch with a special focus on the imaging and approach to the management.
Eugen Helmlé, 1927–2000
Authors: Gipper Andreas
Published: July 2024

Eugen Helmlé (1927–2000) war einer der verwegensten und besessensten Übersetzer seiner Zunft, der an die 150 Bücher übersetzt hat und in ganz besonderer Weise Georges Perec verbunden war, dem herausragenden französischen Autor des 1960 gegründeten Oulipo-Kreises, der gemeinsam mit seinem Übersetzer Helmlé neue formale Wege der Literaturproduktion beschritt.
Die Wirkung drei neuer Substanzen auf mesenchymale Stamm-/ Stromazellen in der lokalen und systemischen Inflammation
Authors:   , Kállai Malin Sophie
Published: July 2024

In Deutschland leidet ca. jeder zehnte Mensch über 40 Jahren an einer chronischen Einschränkung seiner Nierenfunktion. Nicht wenige davon sind im Laufe der Erkrankung auf eine Nierenersatztherapie angewiesen. Die Ursachen für eine Nierenschädigung sind vielfältig. Als neuartiger und vielversprechender Therapieansatz werden aktuell Mesenchymale Stamm-/Stromazellen (MSC) als Therapeutikum für diverse Nierenerkrankungen getestet. Erste Ergebnisse klinischer Phase-I-Studien zeigen, dass MSC sicher als Immunsuppressivum nach Nierentransplantation angewendet werden können. Auch für weitere Erkrankungen der Niere sind erste klinische Studien am Laufen. MSC gelten als regenerativ, immunsupprimierend und antientzündlich. Dennoch gibt es noch einige Limitationen. Nach der Transplantation der Zellen ist das Wachstum der Zellen oft eingeschränkt und es kommt zur vermehrten Apoptose. Auch wird immer wieder ein paradoxes und entzündungsförderndes Verhalten der MSC am Wirkort beobachtet. Ein wichtiger Lösungsansatz ist eine in vitro Vorbehandlung der MSC zur Modulierung der zellulären Eigenschaften. In dieser Arbeit wurden drei Substanzen und Arzneimittel auf ihre Fähigkeit untersucht, die entzündungshemmenden Eigenschaften der MSC zu verbessern und die entzündungsfördernden zu unterdrücken. Der Fokus lag hierbei auf dem Arzneimittel Niclosamid und den beiden bisher noch nicht zugelassenen Substanzen Berberin und Gedunin, die alle in vitro und in vivo bereits erste vielversprechende antientzündliche Wirkungen bewiesen haben. Für diese Arbeit wurden MSC aus Fettgewebe isoliert (ASC) und mit LPS oder einem Cytokin-Mix (Mischung aus TNF-α, IFN-γ und IL-1β) sowie den drei Substanzen stimuliert. Untersucht wurden im Anschluss die mRNA-Expressionen der gängigsten proinflammatorischen (TNF-α, IL-6, TLR-4, ICAM-1, HLA-DR) und antiinflammatorischen Marker (IDO, IL-10), sowie mittels ELISA die Protein-Freisetzung von IL-6 und IL-8. Die vielversprechendsten Ergebnisse ließen sich durch Berberin hervorrufen. Hier zeigte sich eine deutliche Senkung der IL-8-Konzentration im ELISA. Die Anwendung des Gedunin hatte keine signifikante Wirkung auf die ASC. Niclosamid hingegen scheint widererwarten sogar entzündungsfördernd zu wirken, in dem es die IL-6-, ICAM-1-mRNA-Expression steigerte und die IDO-mRNA-Expression absenkte. Unter den drei getesteten Subtanzen hat Berberin die beste Wirkung bewiesen. Nach weiterer Testung könnte eine Anwendung mit Berberin als in vitro Präkonditionierung von MSC vielversprechend sein. Die Verwendung von Niclosamid hingegen sollte vermieden werden, die Wirkung von Gedunin müsste genauer untersucht werden.
Untersuchung zur Wirkung von Tregalizumab auf die allergeninduzierte Atemwegsentzündung bei Patienten mit Hausstaubmilbenallergie
Authors:   , Schließmeyer Julia
Published: July 2024

Einleitung: Allergisches Asthma bronchiale ist eine chronische Atemwegserkrankung, deren Prävalenz zunimmt. Angesichts der immensen gesellschaftlichen und individuellen Belastung durch Asthma ist es dringend erforderlich, neue Strategien zur Behandlung der Krankheit zu entwickeln. Immunologisch ist allergisches Asthma durch ein Ungleichgewicht zwischen TH2-Zellen und TH1-Zellen gekennzeichnet, das durch regulatorische T-Zellen (Tregs) reguliert wird. Tregalizumab ist ein monoklonaler IgG-Antikörper, der Tregs selektiv aktiviert. Ziel der vorliegenden Arbeit war es daher, die Wirkung von Tregalizumab auf die allergeninduzierte allergische Entzündung bei Patienten mit Hausstaubmilbenallergie anhand eines bronchialen Provokationsmodells zu untersuchen. Methoden: In einer prospektiven, randomisierten, doppelblinden und placebokontrollierten Studie wurden 42 Probanden mit allergischem Asthma und Hausstaubmilbenallergie zwölf Wochen lang mit Tregalizumab 100 mg oder Placebo behandelt. Bronchiale Provokation mit HSM wurde vor (V4) und nach (V17) Tregalizumab-Gabe durchgeführt. Induziertes Sputum (Visite V5, V16, V18) und peripheres Blut (Visite V4, V5, V18) wurden entnommen und Zelldifferenzierung, Zytokine und Transkriptionsfaktoren wurden durch Mikroskopie, Durchflusszytometrie bzw. RT-PCR bewertet. Ergebnisse: Sowohl in der Verum- als auch in der Placebogruppe zeigte sich zwischen Visite V5 (24 Stunden nach Provokation) und vier Wochen nach Provokation bei Visite V16 (p<0,05) ein signifikanter Rückgang des Anteils eosinophiler Granulozyten (wie auch des ECP-Levels). Interessanterweise konnte bei V18 (24 Stunden nach Provokation) nur in der Placebogruppe ein signifikanter Anstieg beobachtet werden (p<0,01). Die Konzentration des TH-2-Zytokins IL-5 nahm zwischen V5 und V16 in der Verumgruppe signifikant ab (p<0,05). Zwischen V16 und V18 konnte wiederum nur in der Placebogruppe ein signifikanter Anstieg festgestellt werden (p<0,01). Dieser spätere Effekt wurde auch auf Protein- und Transkriptionsebene und im peripheren Blut sowie bei der Expression des Transkriptionsfaktors FoxP3 gefunden. Auf der Ebene der TH-1-Zytokine konnten keine signifikanten Veränderungen festgestellt werden. Diskussion: Der Anteil eosinophiler Granulozyten, die Konzentration von IL-5 in Blut und Sputum sowie die Konzentration von ECP im Sputum haben sich als gute Parameter zur Beurteilung der Entzündungsreaktion bei unseren Studienteilnehmern erwiesen. Wir haben gezeigt, dass allergische Entzündungen, die durch das Provokationsmodell verursacht wurden, durch die analysierten Parameter im Sputum, aber auch im Blut gut überwacht werden konnten. Ein klinischer Effekt von Tregalizumab konnte in dieser Studie jedoch nicht festgestellt werden und dieses Ergebnis stimmt gut mit der Analyse der Entzündungsparameter im induzierten Sputum überein.
APPLICATION OF INNOVATIVE VIRTUAL REALITY TECHNOLOGY AS A MEANS OF PSYCHOLOGICAL MOTIVATION OF STUDENTS' COMMUNICATION SKILLS DURING TRAINING
Authors: Kurbanova Olha
Published: July 2024

The purpose of the article is to study the effectiveness of using virtual reality as an element of students' psychological motivation to communicate in the educational process. The article analyzes the problem of using immersive technologies as an element of psychological motivation to learn new vocabulary items and increase concentration while immersed in the English-speaking environment. The main focus is on the analysis of various VR practices that affect the emotional state of students, as well as on the study of the potential advantages and limitations of these elements in the learning process.
TWO VARIATIONS ON THE TOPIC OF ST. YUR’S CATHEDRAL IN LVIV (O. NOVAKIVSKYI – I. KALYNETS – M. SOSENKO)
Authors: Savchuk Hryhoriy
Published: July 2024

The purpose of the article is to analyse Ihor Kalynets’s reception of paintings by Lviv artists Oleksa Novakivskyi ‘Yur. The Poem of the World War’ and Modest Sosenko’s ‘St. Yur’s (George’s) Church in Lviv’. The paintings of both artists and their perception by Ihor Kalynets (poems «‘Yur’ by O. Novakivskyi» and «’Yur’ by M. Sosenko») have a lot in common. The painters’ gaze is directed from the bottom up, into the distance, into the future, which is due to the location of the buildings and the angle of observation. However, summarising the observations on Ihor Kalynets’s variations on the topic of the most famous church in Lviv, we should note the prevalence of the distinctive over the common. Oleksa Novakivskyi’s painting provoked the poet’s reflections, which are dominated by the motifs of purity, aspiration and steadfastness, struggle and victory, while Modest Sosenko’s painting evoked a sense of sadness, melancholy and autumnal transparency. The canvas of Lviv artists depict the same object from the same angle, but in different moods. Considering the multivariate artistic perception of the artists, in his works Ihor Kalynets conveys the ‘impression of impressions’ that the artists had while contemplating the majestic building, so these poems contain the features of impressionism. On the other hand, in his ekphrase poems, the poet accumulates the ideological and artistic achievements of three types of art at once: painting (in particular, iconography), literature and architecture. The interaction of these art forms can be summarized on the basis of receptive ‘heredity’, so to speak, the passing of a receptive ‘baton’: the icon of St. Yuriy (George) the Serpent and the architectural masterpiece St. Yur’s Cathedral in Lviv → reception of the cathedral by Oleksa Novakivskyi and Modest Sosenko → the paintings by Oleksa Novakivskyi and Modest Sosenko → reception of those paintings by Ihor Kalynets → the poems «‘Yur’ by O. Novakivskyi» and «’Yur’ by M. Sosenko» → the reader’s reception of the poems. If we take into account that the first mentioning of the cathedral dates back to the thirteenth century (though since then the church has been destroyed and rebuilt), and the reception of the analysed poems continues in the twenty-first century, we have a receptive history of eight centuries.
Yağmur Suyu Hasadı Hesabı: Çorum İli Örneği
Authors: Dağ Murat , Ay Murat
Published: July 2024

Bu çalışma, hidrolojik bir değişken olan yağmur suyunun hasadının önemini, hâlihazırdaki su kaynaklarına alternatif olarak kullanılabileceği ve kuraklığa karşı depolama fonksiyonu ile yağmur suyunun getireceği faydaların ve zararların irdelenmesini içermektedir. Bu kapsamda, Çorum İli Merkez ilçesinde yer alan AHL Park Alışveriş merkezinin yaklaşık 27000 m2 olan çatısında toplanabilecek yağmur suyu potansiyelinin hesaplanması, günümüz ekonomik koşullarında maliyetinin değerlendirilmesi ve öneriler yapılmıştır. İlk yatırım ve işçilik maliyetlerinin yüksek olması, sistemin amortisman süresinin uzun süreler olması (50-100 yıl) ve inşaatı biten bu gibi binalarda sistemin yapım işinin zahmetli, masraflı ve riskli olması sebepleri düşünüldüğünde sistemin uygulanma olasılığının ülkemizde düşük olasılıkta olduğu görülmüştür. Ancak, bu gibi sebeplerin canlıları tehdit eden kuraklık tehlikesi ve kaliteli su sıkıntısı gibi risklere karşı daha zayıf sebepler olduğu söylenebilir. Diğer taraftan, daha verimli ve ekonomik başka alternatif depolama sistemleri geliştirilebilir ve yağmur suyu hasadı sistemleri farklı su hasadı sistemleri (örneğin yeraltı suyu) ile bütünleştirilebilir. Ülkemizde yağmur suyu hasadı ile ilgili daha ayrıntılı bir yönetmeliğe ihtiyaç olup şimdilik bir hesap ve öngörü oluşması için Almanya ve İngiltere gibi ülkelerinin yönetmeliklerinin kullanılması tavsiye edilmektedir.
Uzaktan Algılama ve Coğrafi Bilgi Sistemleri Kullanılarak Yangın Hasarının ve Yangına Duyarlı Alanların Belirlenmesi: Aydıncık (Mersin) İlçesi Örneği, Türkiye
Authors: Ocak Fatih , Cesur Feride , Ismail Amira , Keklik Sevim
Published: July 2024

Akdeniz iklim kuşağında yer alan bir ülke olması sebebiyle Türkiye’de her yıl yüzlerce orman yangını meydana gelmekte ve bu yangınlar birçok zarara sebep olmaktadır. Bu zararın azaltılmasında orman yangınlarını önlemek ne kadar önemliyse yangın tahribatının azaltılması da o denli önemlidir. Dolayısıyla muhtemel bir yangın öncesinde hem erken yangın tespiti ve erken müdahale hem de tahribatın azaltılmasında orman yangınına duyarlı alanlar belirlenmelidir. Bu bağlamda Mersin’in Aydıncık ilçesinde 2021 Temmuz ayında meydana gelen orman yangınının oluşturduğu hasarı tespit etmek ve yangına duyarlı alanları belirlemek için bu çalışma gerçekleştirilmiştir. Çalışmanın ilk bölümünde Uzaktan Algılama (UA) teknikleri ile yangın öncesi-sonrası arasındaki farkı belirlemek için Landsat 8 OLI/TIRS uydu görüntüleri kullanılarak NDVI (Normalize Edilmiş Bitki Örtüsü İndeksi), NBR (Normalize Edilmiş Yanma Şiddeti) ve dNBR (Fark Normalize Edilmiş Yanma Şiddeti) indeksleri hesaplanmıştır. Çalışmanın ikinci bölümünde ise orman yangınına duyarlı alanlar belirlenerek Aydıncık ilçesinin Coğrafi Bilgi Sistemleri (CBS) destekli orman yangını duyarlılık haritası oluşturulmuştur. NDVI indeksine göre 2020 yılında %13,43 olan çıplak arazi ve yerleşmelerin 2021 yılında %23,02’ye yükseldiği, farklı orman yoğunluklarının olduğu alanlarda ise azalma olduğu tespit edilmiştir. dNBR indeks sonuçlarına göre; %27,67’lik bir alanın (12.153,83 ha) yangından orta-yüksek derecede hasar gördüğü ve farklı bitki yoğunluğundaki alanlarda kayıplar olduğu belirlenmiştir. Ayrıca, orman yangını duyarlılık analizine göre sahanın %7,82 çok düşük, %22,46 düşük, %28,65 orta, %28,56 yüksek ve %12,50 oranında çok yüksek duyarlılık gösterdiği tespit edilmiştir.
Decorated defect construction of gapless-SPT states
Authors: Li Linhao , Oshikawa Masaki , Zheng Yunqin
Published: July 2024

Symmetry protected topological (SPT) phases are one of the simplest, yet nontrivial, gapped systems that go beyond the Landau paradigm. In this work, we study an extension of the notion of SPT for gapless systems, namely, gapless symmetry protected topological states. We construct several simple gapless-SPT models using the decorated defect construction, which allow analytical understanding of non-trivial topological features including the symmetry charge under twisted boundary conditions, and boundary (quasi)-degeneracy under open boundary conditions. We also comment on the stability of the gapless-SPT models under symmetric perturbations, and apply small-scale exact diagonalization when direct analytic understanding is not available.
“My mother is schizophrenic.” A collaborative autoethnography of a daughter experiencing a mother with schizophrenia
Authors: An So-young , Kim Myeung-Chan
Published: July 2024

Objectives: First, this study aimed to empathize with and understand family members other than patients with schizophrenia and mental disabilities. Second, this study aimed to help those who work in mental health professions by emphasizing the importance of an empathetic and supportive attitude. Finally, this study confirms the importance of healing relationships between family members, further promoting a social understanding of schizophrenia. Methods: A collaborative autoethnography research method was used. The researcher's memory data, professor interviews, website articles, family interviews, the mother's diary, and the researcher’s diary were collected, analyzed, and classified. Results: Results of qualitative data analysis found the top three categories identified were “mother's schizophrenia begins”, “standing at the edge of a cliff”, and “mother and I facing a field”, along with seven sub-categories. Conclusions: Emotional and psychological pain were explored by describing the personal experiences of a researcher with a mother with the mental disorder schizophrenia from the perspective of an insider. Beyond personal problems, it was resolved reflectively while looking at the of whole of society through a lens of socio-cultural vulnerability and problem consciousness. The study discusses the implications in terms of the process and socio-cultural meaning.
Excellence or perfection: Examining work performance mediated through employee engagement in India
Authors: Kohli Kanika , Tyagi Archana , Khurana Poonam , Prabhu Nandan
Published: July 2024

The model of excellencism and perfectionism (MEP) theorizes that the attitude toward goals as characterized in excellencism is desirable over perfectionism. Using the self-determination theory (SDT), this study aims to investigate the varying effects of perfectionism and excellencism on work engagement and performance. The study used a time-lagged multi-phase, multi-source, and cross-sectional online survey to collect responses from 360 corporate employees of Indian companies in the services industry. The results indicate that while both perfectionism and excellencism entail pursuing high standards, they relate differently with performance and work engagement. Interestingly, excellencism and work engagement were significantly associated with performance (p < .001); however, perfectionism was insignificant (p = .989). Perfectionism strengthens work engagement (β = 0.112; p = .013), while excellencism has an insignificant effect (β = 0.035; p = .537). Work engagement fully mediates the perfectionism-performance relationship. This demonstrates that striving for excellence alone is sufficient to achieve positive performance, challenging the traditional belief that one must focus on perfection. Furthermore, perfectionism is positively associated with performance only when employees are engaged and have positive motivation toward work.
Prediction of Sudden Cardiac Death with Feature Selection Using Particle Swarm Optimization
Authors: David David , Muhamad Isa Sani
Published: July 2024

The heart, a vital organ responsible for pumping oxygenated blood through blood vessels, is susceptible to disturbances in heart rate that can have adverse effects. According to data from the World Health Organization (WHO) since 2000, this disease has experienced the most significant increase in fatalities, rising from over 2 million to 8.9 million deaths. The prediction of Sudden Cardiac Death (SCD) continues to gain attention as a promising approach to saving millions of lives threatened by the occurrence of the disease. In this study, we propose the utilization of Particle Swarm Optimization (PSO) as a feature selection method to train the Support Vector Machine (SVM) and Logistic Regression. By employing the proposed algorithm, SCD can be predicted up to 30 minutes before the onset with an accuracy of 92.5%, by using PSO and SVM. Features are extracted from Heart Rate Variability (HRV) analysis and Discrete Wavelet Transform (DWT) obtained from ECG records of MIT-BIH normal sinus rhythm database & MIT-BIH Sudden Cardiac Death Holter database dataset. This paper also compares feature selection algorithm of PSO and Analysis of Variance (ANOVA) and found that PSO is better in accuracy, recall, and F1-score.
Influence of Character Image to Word-of-Mouth Through Gamer Satisfaction of Impulse Spending in the Genshin Impact Mobile Game
Authors: Reynaldo Kevin , Salehudin Imam
Published: July 2024

This research aims to understand the influence of character image (symbolic representation and self-image congruence) on impulse buying and satisfaction in word-of-mouth recommendations for the game Genshin Impact in Indonesia. Hence, the study explored the potential of character image by spreading online survey to gen Z Genshin Impact gamers in Indonesia. The hypotheses in this study were tested using Structural Equation Modelling (SEM) with Lisrel 8.8. The significant results of this study to show character image have positive influence between impulse buying, satisfaction, and word-of-mouth. Character image is one of the important factors in increasing revenue for game companies, as seen in Genshin Impact, where the selling point of sales come from in-game character that make the company’s revenue increase.
ÜNİVERSİTE ÖĞRENCİLERİNİN KARŞILAŞTIĞI SORUNLAR VE ÜNİVERSİTE SOSYAL HİZMETİ UYGULAMASI ÜZERİNE BİR DEĞERLENDİRME
Authors: Yelboğa Nurullah
Published: July 2024

İnsanlar yaşamlarının her döneminde çeşitli güçlüklerle karşı karşıya kalmaktadır. Üniversite öğrencilerinin önemli gelişimsel bir dönemde olmaları, rutinlerin değiştiği bir süreç olarak üniversitede olmaları ve içinde bulundukları diğer bazı koşullar onları birçok sorunla karşı karşıya bırakabilmektedir. Literatürde öğrencilerin maddenin kötüye kullanımı, intihar eğilimi, zorbalık, saldırganlık, cinsiyet eşitsizliği, ayrımcılık, obezite, sosyal medya bağımlılığı, uyum sorunları, evsizlik, psikososyal sorunlar, finansal sorunlar, beslenme sorunları, akademik sorunlar başta olmak üzere birçok sorun yaşadıkları belirtilmektedir. Bu çalışma, üniversite öğrencilerinin karşılaştıkları sorunları daha görünür kılmayı ve söz konusu sorunları sosyal hizmet perspektifiyle değerlendirmeyi amaçlamaktadır. Bu bakışla üniversite sosyal hizmeti ve danışmanlık birimleri üzerinden tartışma sürdürülerek üniversite sosyal hizmetinin gerekliliğine vurgu yapılmıştır. Sosyal hizmetin her geçen gün genişleyen bilgi yelpazesi ve çalışma alanları olmakla birlikte ülkemizde bazı alanlar literatürde yeterince ele alınmamıştır. Üniversite sosyal hizmeti de yeni bir tartışma alanı olarak henüz sağlam bir zeminde irdelenmiş ve tartışılmış değildir. Bu çalışmanın söz konusu alan için tartışma kapısını aralaması ve alana zenginlik katması amaçlanmaktadır.
CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF EXTRACTS AND ISOLATED COMPOUNDS FROM THE ROOTS OF Bowdichia virgilioides (Fabaceae)
Authors: Cardoso Klauber , dos Santos Darlan , David Jorge Mauricio
Published: July 2024

This study describes the chemical composition and biological activities of extracts and compounds obtained from the roots of Bowdichia virgilioides (Fabaceae). A mixture of very long-chain free fatty acids (VLFAs) and pure compounds, namely isocordoin, cordoin, lupeol, lupenone, β-sitosterol, stigmasterol, and sitostenone, were isolated from the soluble fraction of the methanol extract by using sequential column chromatography procedures. The molecular structures of the compounds were determined using infrared (IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS) techniques. Notably, this is the first report of the occurrence of both chalcones within this plant genus. Besides, the VLFAs were identified by electrospray ionization mass spectrometry (ESIMS) and the presence of these compounds in roots is suggested to be an adaptive response to environmental stress, which exhibited moderate antioxidant properties when tested against the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and in the β-carotene/linolenic acid auto-oxidation assay. However, the MeOH soluble fraction demonstrated significant toxicity in the brine shrimp lethality assay.
Secure metric dimension of new classes of graphs
Authors: Batiha Iqbal M. , Mohamed Basma , Jebril Iqbal H.
Published: July 2024

The metric representation of a vertex v of a graph G is a finite vector representing distances of v with respect to vertices of some ordered subset S⊆V (G). If no suitable subset of S provides separate representations for each vertex of V(G), then the set S is referred to as a minimal resolving set. The metric dimension of G is the cardinality of the smallest (with respect to its cardinality) minimal resolving set. A resolving set S is secure if for any v∈V–S, there exists x∈S such that (S–{x})∪{v} is a resolving set. For various classes of graphs, the value of the secure resolving number is determined and defined. The secure metric dimension of the graph classes is being studied in this work. The results show that different graph families have different metric dimensions.
Value Preferences in Civil Servant Career: Kazakhstan and Russia
Authors: Lazarenko Dmitriy , Antilogova Larisa
Published: July 2024

Changes affect people’s lives and their attitude to work, including civil service. Civil servants represent the interests of citizens. The quality of public service depends on the professionalism of civil servants, their competencies, and psychological profile, e.g., values. One’s system of values determines one’s attitude to work and life, e.g., professional motivation and career path. The research objective was to describe the effect of personal values on career preferences in civil servants. It revealed a certain correlation between the value system and career orientations. Civil servants should develop their talents to build an individual career path. At the state level, both Russia and Kazakhstan take a number of measures to manage the career of civil servants by developing their talents and value preferences, which should be determined in early stages. The article also contains some practical value-oriented recommendations for career development of civil servants.
Advocates in China: History and modernity
Authors: Troshchinskiy Pavel V. ,   Institute of China and Contemporary Asia of the Russian Academy of Sciences
Published: July 2024

The article examines the historical development of advocacy in China and the role of lawyers in Chinese society, spanning from ancient times to the present day. Traditional Chinese society held a negative perception of legal processes and positive law. It was widely believed that individual interests should be subordinated to collective interests and seeking legal redress in court was seen as conflicting with the moral norms of “li”. Chinese officials typically sought to avoid resolving disputes through the judicial system, instead promoting mediation and pretrial dispute resolution. This negative perception of legal processes led to resistance against the activities of lawyers, with the profession being viewed disrespectfully by officials. Over time, a prevailing sentiment emerged among the public that advocates were more inclined to support the guilty party rather than defend the innocent. The advocate was widely seen as being biased, protecting criminals, and enabling them to avoid just punishment. Lawyers faced numerous obstacles in participating in legal proceedings and often encountered hindrances in providing advice to defendants, including instances of physical harm. After the establishment of the People’s Republic of China in 1949, the perception of advocates remained largely unchanged. The Chinese legal profession was effectively dismantled during the destructive political campaigns from 1958 to 1966 and began to reemerge only after the implementation of the “reform and openness” policy in 1978. Initially, lawyers were appointed as civil servants, but this status was later revoked. Despite long-standing skepticism towards advocates, the legal profession in modern China is gradually gaining popularity, although progress is slow and the overall number of advocates in China remains relatively small. They still hold a formal role in criminal proceedings, while the majority of cases seeking legal assistance from advocates are primarily related to civil proceedings. Even though the need for the existence of the advocacy is no longer denied, its significant role in modern China is still not fully recognized.
Application and theoretical development of artificial intelligence in civil proceedings
Authors: Gong Nan ,   Heilongjiang University, Dong Dongxue ,   Northeast Agricultural University
Published: July 2024

With the development of artificial intelligence technology, the scope of application of artificial intelligence in the judicial field continues to expand, and the intelligent auxiliary system of decision-making has taken root in courts throughout China, which not only greatly alleviates the problem of “the existence of a large number of cases and a small number of people” and increases judicial efficiency, but also, by assisting judges in considering cases, also contributes to the uniform application of laws and the normalization of norms for exercise of discretionary powers. A prerequisite for the judicial application of artificial intelligence is the construction of a map of legal knowledge, as well as the typification and elementalization of the rules of litigation. The theory of justice by legal compositions in legal proceedings and the law of the formation of the use of artificial intelligence in justice are inherently compatible, and can be used as an advanced and basic theory for deep neural network learning, setting up word segmentation and designing a knowledge map. The specific application pathway is to continuously perform hierarchical deconstruction in accordance with the theory of justice by legal compositions, deconstruct the establishment of the existence of facts and apply deconstruction regulations to different levels of elements, and their hierarchical and step-by-step marking by legal experts to form a big data map of legal knowledge, marked by elements, for machine learning. To this end, the theoretical tool of the intelligent assistive decision-making system model should implement the transition from “legal logic + artificial intelligence” to “legal logic + philosophy of procedural law + artificial intelligence” so that intelligent auxiliary litigation can truly be integrated into judicial practice.
The system of legal regulation of state control in the People’s Republic of China
Authors: Trofimov Albert А. ,   St. Petersburg State University
Published: July 2024

In light of the ongoing reform of control and supervisory activities in Russia, it is of interest to study the current legal regulation of state control in historically related legal orders, in particular, in the PRC. Although China does not have a single normative act dedicated to the procedure, grounds and methods of exercising state control, its norms are systematically included in various sectoral normative acts. Among others, various types of state control in China can be distinguished: sectoral, central and local, departmental and interdepartmental. The state directs controlling bodies to apply advanced information technologies, scientifically-based methods of planning and implementation of control measures, as well as the implementation of a risk management system. It can be argued that there is a whole system of norms dedicated to state control in China at the current stage of development of Chinese legislation, which is not a complete legal institution. This article considers on the example of individual administrative legal norms how the Chinese legislator approaches the issue of finding a balance between public and private interests in the implementation of state control of private entities through the normative consolidation of specific guarantees of the rights and legitimate interests of controlled persons and specification of powers of controlling bodies, which still remain in many cases broad and not fully defined.
Unfair competition and antitrust regulation in the field of Internet financial platforms in China
Authors: Wang Guanglong ,   Kutafin Moscow State Law University
Published: July 2024

The presented article analyzes unfair competition in the field of China’s Internet financial platforms, which is mainly reflected in three aspects such as resistance and rejection by traditional financial platforms in relation to developing Internet financial platforms; resistance and rejection between Internet financial platforms; monopoly problems that the platform itself may face. The paper notes that large-scale platform complexes use the advantages of platforms, data, algorithms and users for random expansion into various industries and penetration into financial markets in order to form a monopoly of the platform-financial complex. This has caused widespread damage to competition, innovation, consumer rights and interests, as well as the stability of the financial system. Therefore, it is urgently necessary to create and improve the management system of the platform economy for its regulation and management. According to the author, the typed means of suppressing anticompetitive behavior in the field of Internet financial platforms should be manifested in such aspects as the construction of a mechanism for antimonopoly supervision of Internet financial platforms; improvement of the mechanism for the examination of regulatory measures in the field of Internet finance; creation and improvement of the mechanism of public supervision.
Soft sensor for substrate characterization through the reverse application of the ADM1 model for anaerobic digestion plant operations
Authors: Zorrilla Fernando , Sadino-Riquelme Ma. Constanza , Hansen Felipe , Donoso-Bravo Andrés
Published: July 2024

Accurately characterizing the substrate used in anaerobic digestion is crucial for predicting the biogas plant's performance. This issue makes particularly challenging the application of modeling in codigestion plants. In this work, a novel methodology called substrate prediction module (SPM) has been developed and tested, using virtual codigestion data. The SPM aims to estimate the inlet properties of the substrate based on the reverse application of the anaerobic digestion model n1 (ADM1). The results show that, while the SPM can estimate some properties of the substrate based on certain output parameters, there are limitations in accurately determining all required variables.
A RELAÇÃO UNIVERSIDADE-EMPRESA-GOVERNO EM PARQUES TECNOLÓGICOS BRASILEIROS EM DESENVOLVIMENTO
Authors: Garcia Arcentales John Jairo , Ferreira de Araujo Ronaldo , Sousa de Araujo Eliete
Published: July 2024

The technological parks have experienced growth in the country and have a rich ecosystem of innovation that brings together a variety of actors, highlighting research institutions, the private sector, and the government. The study aims to analyze the relationship between university, companies, and government in technological parks in the implementation phase in Brazil. Using documentary analysis and asymmetric observation, 82 documents from three poles were examined from the perspective of speech act theory. Seven units of analysis were established: introductory aspects, innovation, infrastructure, institutional feasibility, organizational identity, organizational environment, and local culture. The sample included the Technological Park of Brasília - BIOTIC in Brasília, the Technological Park Foundation of Santos, São Paulo State, and the Scientific and Technological Park of UFRGS, Porto Alegre. The results indicate that cooperation among these actors is essential for the development of technological parks, contributing to the creation of sources of knowledge, innovation, and entrepreneurship. BIOTIC and Zenit Park are initiatives born from the academic environment, contrasting with the technological parks of Santos, mainly driven by the government sector. This distinction highlights different models of development and support for technological parks in Brazil, reflected in their structures, operations, and regional impacts. The research concludes that the construction of the triple helix is catalyzed by the collaboration of these actors, especially regional governments interested in fostering the economy. Additionally, technological innovation in companies is strengthened by academic research, reinforcing National Innovation Systems (NIS).
Impact of Tyrosine Kinase Inhibitors (TKIs) on Growth in Children and Adolescents with Chronic Myeloid Leukemia: A Systematic Review
Authors: Katsarou Dimitra , Kotanidou Eleni P. , Tsinopoulou Vasiliki Rengina , Tragiannidis Athanasios , Hatzipantelis Emmanouil , Galli-Tsinopoulou Assimina
Published: July 2024

Background:

Chronic Myeloid Leukemia (CML) is a rare myeloproliferative disease in childhood.
Treatment in CML includes Tyrosine Kinase Inhibitors (TKIs), which inhibit the cytoplasmic kinase
BCR/ABL. Tyrosine kinases play a key role in the secretion of growth hormone and insulin-like growth factor
1 (IGF-1).

Objective:

The aim of this systematic review was to study the effect of TKIs on the growth of children and adolescents
with CML.

Methods:

English-language publications were searched in the PubMed/Cochrane library/Google Scholar
databases (2002-2023), and retrieved studies were assessed according to PRISMA-Statement and Newcastle-
Ottawa-scale.

Results:

The search strategy yielded 1066 articles. After applying the inclusion/exclusion criteria, 941 were excluded
based on title screening and 111 on abstract review. The systematic review included 14 articles (11 retrospective
observational studies/3 clinical trials). Twelve studies reported data on the prevalence of growth disorders
after the administration of 1st generation TKIs (imatinib). Two studies reported a negative effect of 2nd
generation TKIs (dasatinib/nilotinib) on physical growth. Four studies recorded a decrease in height z-score after
treatment compared to baseline. Two 1st-generation TKIs studies reported data on children's final height;
one reported restoration of final height to normal after the onset of puberty, despite initial slowing, and the final
height was lower than mid-parental target height. Serum IGF-1 levels were reported in 2 studies to be
within normal range, while in 3 studies, a significant decrease was documented. Considerable study heterogeneity
was observed related to dosage/duration of treatment/disease phase/stage of puberty/ethnicity.

Conclusion:

A negative effect of TKIs on the growth and final height of children was noted.
Antifungal Potential of Endophytic Metabolites Derived from
Staphylococcus: An In-Vitro and In-Silico Approach
Authors: Kumari Sudesh , Choudhary Pooja , Ahlawat Vaishali , Dangi Mehak , Chhillar Anil Kumar
Published: July 2024

Introduction:

Nature is full of surprises; it gives us problems along with solutions, but
the only condition is that it needs to be explored. The ability of endophytes to tackle pathogens is
one such example that falls within the context of the current work. In the current study, we have
assessed the antifungal potential of endophytic bacterial metabolites of medicinal importance
through in-vitro and in-silico studies.

Materials and Methods:

Bioactive metabolites from Staphylococcus species, an endophytic bacterium, were extracted to assess their antifungal potential through disc diffusion assays and minimum inhibitory concentration determination. Gas Chromatography-Mass Spectroscopy characterized the diverse composition of the endophytic extracts. The interactions between these metabolites and target proteins, such as CYP51B in Aspergillus fumigatus, were revealed by in-silico
studies, which included molecular docking and dynamics simulations. This provided a thorough
understanding of the antifungal qualities inherent in endophytic bacterial metabolites.

Results:

The research findings highlighted that the zone of inhibition (ZOI) exhibited by
the crude extract from Staphylococcus endophytes (23.6±1.24 mm) is comparable to that of
the control, Voriconazole (23±0.82 mm). Additionally, the minimum inhibitory concentration
of the crude extract (0.21±0.06 mg/ml) is lower than the control (0.33±0.11 mg/ml). Notably,
among the 45 identified endophytic metabolites, Pyrrolo [1,2-a]pyrazine-1,4-dione, hexahydro-3-
(phenylmethyl), demonstrated superior inhibition efficacy against CYP51B (PDB Id: 4UYM) of
Aspergillusfumigatusascompared to Voriconazole. These findings emphasized the potential of the
identified metabolite as a promising antifungal agent.

Conclusion:

The endophytic metabolite, Pyrrolo [1,2-a]pyrazine-1,4-dione, hexahydro-3-
(phenylmethyl), showcased significant antifungal potential as a therapeutic agent against fungal
infections.