bluuebunny/crossref_metadata_2025 huggingface dataset:
The essence and content of climate financing
Authors:   SESE “The Academy of Financial Management”, Shcherbakova Olena
Published: December 2024

Introduction. The present day is characterized by the destructive consequences of climate change, such as rising temperatures, prolonged droughts, melting glaciers, sea-level rise, catastrophic floods, extreme weather events, and emergencies; biodiversity loss; increasing forest fire risks; declining land productivity; crop failures; reduced eco-friendliness of agricultural products; degradation of fish stocks; increased morbidity and mortality; limited tourism; migration, and humanitarian issues such as loss of property and livelihoods. It can be stated that there is a triple planetary crisis: climate change, biodiversity loss, and environmental pollution. Consequently, the global community's agenda includes counteracting these negative consequences for humanity – not only minimizing the negative impact but also restoring ecosystems.

Problem Statement. Achieving these goals is impossible without proper financial support, which is feasible primarily through a clear understanding of the essence, content, and functions of climate financing, identifying its directions and types, and developing a conceptual model for climate financing.

Objective. To define the essence and content of climate financing.

Methods. A systematic approach, monographic and historical methods, methods of generalization, comparative and expert analysis were used.

Results. Approaches to interpreting climate financing have been clarified, its significance, essence, and content have been identified. The authors present definitions of the terms «climate finance» and «climate financing», a classification of its types, and directions of climate financing.

Conclusions. Taking into account such components of climate financing as funding for public climate, environmental, industrial, and energy policies that promote the implementation of projects for prevention / mitigation / adaptation to climate change / restoration / transformation; financing public / private / mixed climate investments; and elements of the financial system related to climate finance will enable the effectiveness of measures in combating the negative consequences of climate change.
Comparative analysis of visual function indicators in schoolchildren with partial optic nerve atrophy and amblyopia
Authors: Rychkova S. I. , Laver A. B. , Kurysheva N. I.
Published: December 2024

Introduction. Visual impairments present significant challenges for learning in school, limit career choice, and restrict participation in sports. Therefore, the developing a comprehensive diagnostic system for assessing visual functions in children with functional and organic ophthalmopathology is a pressing tasks in modern ophthalmology. The aim is to further advance effective treatments and medical-pedagogical support for such children. Purpose: to conduct a comparative analysis of visual function indicators in schoolchildren with partial optic nerve atrophy (PONA) and amblyopia in order to create an effective diagnostic system for detecting monocular and binocular visual function disorders. Materials and methods. The study observed 120 school-age children with PONA, of whom 85 had strabismus and 35 did not. The group of schoolchildren with amblyopia consisted of 98 children (40 with dysbinocular amblyopia and 58 with refractive amblyopia). The control group included 67 children without ophthalmopathology. In addition to standard ophthalmological examinations, electrophysiological parameters (electrical sensitivity threshold and electrical lability), fusion amplitude, binocular and stereovision presence, stereokinetic effect, and visual memory indicators were assessed. Results. The study revealed that, along with organic causes of visual impairment (such as significant decreases in visual acuity, narrowing of visual fields, and worsening electrophysiological parameters), children with PONA also exhibited binocular visual function disorders. These included reduced fusion amplitude, absence of binocular and stereovision, and dominance of monocular spatial perception mechanisms. Binocular disorders were observed in children both with and without strabismus, while among children with amblyopia, these disorders are mainly associated with the dysbinocular form. A decrease in visual memory indicators was identified in both children with PONA and those with amblyopia. Conclusion. Binocular vision disorders and reduced visual memory were observed in schoolchildren with both partial optic nerve atrophy and amblyopia. However, binocular visual function disorders in children with PONA were identified both in the presence of strabismus and orthotropy, unlike children with amblyopia, who primarily exhibited binocular disorders in the presence of strabismus. The inclusion of visual memory and spatial perception indicators in the diagnosis and monitoring of visual functions supports a more individualized approach to the medical and pedagogical care of children with ophthalmopathology.
Determinantes de la internacionalización empresarial en el sector G46 de Ecuador (2018-2021)
Authors: Ortega-Orellana María-José , Pinos Luzuriaga Luis Gabriel , Abad Merchán Matías , Torres Dávila Antonio Fabián
Published: December 2024

Este estudio examina los determinantes de la internacionalización de las empresas ecuatorianas del sector G46 (comercio al por mayor, excepto vehículos automotores y motocicletas) durante el período 2018-2021. Utilizando datos de la Encuesta Estructural Empresarial (ENESEM) y aplicando un modelo logit a una muestra de 1492 empresas, se identificaron tres factores clave que influyen en la probabilidad de exportación: el capital extranjero, el tamaño de la empresa y la antigüedad. Los resultados indican que las empresas con capital extranjero son 2,83 veces más propensas a exportar que aquellas sin este tipo de capital. El tamaño de la empresa, medido por el logaritmo de los ingresos operacionales, también mostró una relación positiva con la probabilidad de exportación. En contraste, se encontró una relación inversa entre la antigüedad de la empresa y su propensión a exportar. Estos hallazgos proporcionan una comprensión más profunda de los factores que impulsan la internacionalización en este sector clave de la economía ecuatoriana y ofrecen valiosas implicaciones para las empresas que buscan expandirse hacia mercados internacionales, así como para los formuladores de políticas públicas enfocadas en promover la internacionalización empresarial.
Como transitar de changarro a franquicia: diseño de un modelo de negocio para una empresa que elabora comida típica mexicana
Authors: Arellano-González Alejandro , Carballo-Mendívil Blanca , Ríos-Vázquez Nidia Josefina , Lizardi-Duarte María del Pilar
Published: December 2024

Las pequeñas empresas que logran sobrevivir más de cinco años se pueden posicionar en el mercado y obtener una ventaja comparativa que les permite operar con márgenes de ganancia aceptables. Un ejemplo es una pequeña empresa alimentaria que, tras 35 años, ha mantenido su presencia en un mercado muy competido, sin embargo, no ha crecido ni avanzado al siguiente nivel de madurez empresarial, funcionando aún como un “changarro” con una estructura y procesos informales, reflejando una administración empírica y poco eficiente. Ante esta situación, surge la siguiente pregunta de investigación: ¿Cómo puede una empresa de comida típica mexicana evolucionar de ser un changarro a una entidad formalmente establecida con potencial para convertirse en franquicia? Para responder a esta pregunta, se aplica la metodología de diseño de sistemas organizacionales en sus fases de análisis y diseño, considerando el enfoque de sistemas y los aspectos teóricos de la teoría de la ventaja competitiva de Michael Porter que permiten a la empresa crear valor para sus clientes. El modelo propuesto se apoya en los fundamentos teóricos planteados por Osterwalder en la metodología Canvas, con un planteamiento estratégico y de negocios que define las decisiones agregadas para construir el modelo de valor. Al final, se realiza una representación esquemática del modelo de negocio para resaltar sus principales características técnicas. El alcance de esta propuesta es solo el diseño del modelo de negocio ecléctico a primer nivel de detalle en una representación esquemática. Se concluye que, técnicamente, es sencillo construir un modelo de negocio; lo complicado es el cambio organizacional que debe ser impulsado por el fundador de la empresa y la inversión requerida para hacerlo.
Fatty Acids of Erythrocyte Membranes and Blood Serum as Biomarkers for Detection of Steatohepatitis in Patients with Alcoholic Fatty Liver Disease
Authors:   Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Kruchinina M.V. ,   Novosibirsk State Medical University, Osipenko M.F. , Parulikova M.V. , Gromov A.A. , Kruchinina E.V.
Published: December 2024

The aim of the work was to study the features of fatty acids of erythrocyte membranes and blood serum in patients with alcoholic fatty liver disease (AFLD) with different necroinflammatory activity to identify biomarkers of steatohepatitis.
Material and methods. 43 men (48.5 ± 8.1 years) with AFLD with different degrees of necroinflammatory activity according to the AshTest test were examined: Group 1 (n = 23) with minimal activity of A0–1 (steatosis), Group 2 (n = 20) – with pronounced activity of A2–3 (steatohepatitis). The study of the composition of fatty acids (FAs) of erythrocyte membranes and blood serum was carried out using gas chromatography/mass spectrometry (Agilent 7000B, USA).
Results. The levels of arachidonic acid C20:4n-6 (p = 0.000018), total content (C20:5n-3+ C22:6n-3) (p = 0.0027), total content of all omega-3 polyunsaturated fatty acids (PUFA) (p = 0.003), levels of docosahexaenoic acid C22:6n-3 (p = 0.0046), docosapentaenoic acid C22:5n-3 (p = 0.0054), docosatetraenoic acid C22:4n-6 (p = 0.01), eicosapentaenoic acid C20:5n-3 (p = 0.048) in erythrocyte membranes and the same acid in blood serum (p = 0.0015) were statistically significantly higher in patients with alcoholic steatohepatitis. In contrast, the concentrations of α-linolenic acid C18:3n-3 (p = 0.0032), hexadecadienoic acid C16:2 n-6 (p = 0.026), palmitoleic acid C16:1;9 (p = 0.033), pentadecanoic acid C15:0 (p = 0.04), the SFA/PUFA ratios (p = 0.017), SFA/UFA (p=0.029) were lower in patients with alcoholic steatohepatitis compared to steatosis. The use of levels of individual FAs or their total content in erythrocyte membranes provided sufficient levels of diagnostic accuracy in distinguishing the degree of necroinflammatory activity in patients with AFLD: arachidonic acid – AUC 0.940, sensitivity 85.7%, specificity 84.6%; total PUFA content – AUC 0.874, sensitivity 78.6%, specificity 84.6%; docosapentaenoic acid – AUC 0.876, sensitivity 78.6%, specificity 76.9%; sum content (C20:5n-3 + C22:6n-3) – AUC 0.863, sensitivity 71.5%, specificity 84.6%. The combined ᾽panel᾽, including a minimum amount of FAs of erythrocyte membranes – C20:4n-6, C18:3n-3, SFA/PUFA, provided the highest levels of diagnostic accuracy – AUC 0.954; 95% CI 0.8-1.0, sensitivity 92.7%, specificity 90.3%.
Conclusion. FAs of erythrocyte membranes, blood serum should be considered as promising pathogenetically substantiated biomarkers for identifying patients with steatohepatitis in AFLD.
Eosinophilic Esophagitis: Modern Ideas about the Disease, Own Clinical Observations
Authors:   Immanuel Kant Baltic Federal University, Kaliningrad, Shchelochenkov S.V. ,   Omsk State Medical University,   A.S. Loginov Moscow Clinical Scientific Center, Bordin D.S. , Shchelochenkova T.D. , Livzan M.A. , Guskova O.N. ,   Russian University of Medicine, Moscow,   Tver State Medical University
Published: December 2024

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus that requires lifelong therapy and monitoring. The diagnosis is established on the basis of an endoscopic examination of the esophagus with a multifocal biopsy of the mucous membrane and the detection of at least 15 eosinophils in the field of view (≈ 60 eosinophils/mm2) at high magnification. The incidence and prevalence of EoE have increased significantly in recent decades, with an average delay in diagnosis of EoE of 4–6 years in both children and adults. Early detection of EoE depends on recognition of the initial clinical manifestations, which vary significantly between children and adults, as well as among patients of the same age. Approaches to the treatment of EoE have not been fully developed and include dietary recommendations, medications, and endoscopic methods at the stage of formation of esophageal strictures. This article reviews the epidemiological, clinical, endoscopic and morphological features of the disease, as well as therapeutic options for EoE, and presents clinical observations.
The Fixed Combination of Metformin and Sitagliptin: Additivity of the Effects for Successful Management of Glycaemia and Cardiovascular Risks in Patients with Type 2 Diabetes Mellitus
Authors:   Siberian State Medical University, Arkharova P.S. , Saprina T.V.
Published: December 2024

Various classes of drugs are used for the treatment of type 2 diabetes mellitus, both in monotherapy and in combination. In elderly patients, people at high risk of hypoglycaemia and at the onset of the disease it is recommended to prescribe a combination of metformin and dipeptidyl peptidase 4 inhibitors (glyptins). This article reviews the mechanisms of hypoglycaemic action of drugs, pleiotropic effects of metformin and sitagliptin, and the efficacy of the combination of these drugs against type 2 diabetes mellitus, lipid metabolism disorders and oxidative stress.
Evaluation of the Effectiveness of Zoledronic Acid Preparations for Parenteral Use
Authors:   Clinics of Samara State Medical University, Shafieva I.A. , Bulgakova S.V. , Kurmaev D.P. , Treneva E.V. ,   Samara State Medical University,   Ministry of Health of the Samara region
Published: December 2024

Bisphosphonates are one of the main drugs for the treatment of postmenopausal osteoporosis. This group of drugs includes zoledronic acid (zoledronate), used for intravenous administration. Zoledronic acid has an antiresorptive effect and is used to treat various bone diseases, including osteoporosis. Currently, generic preparations of zoledronic acid, including Osteostatics, have become widespread.
Aim – to compare the effectiveness of the generic preparation of zoledronic acid 5 mg (Osteostatics) with the original preparation of zoledronic acid 5 mg (Aclasta) in postmenopausal osteoporosis.
Material and methods. During 2021–2022, we examined 139 patients with postmenopausal osteoporosis. The patients were divided into two groups. The first group (69 people) received a generic drug (generic) of zoledronic acid Osteostatics. The second group (70 people) is the original preparation of zoledronic acid Aclasta. All patients additionally received 1000 mg of calcium carbonate and 2000 IU of vitamin D daily.
Patients of both groups repeated measurement of bone mineral density (BMD) 6 and 12 months after infusion of zoledronic acid.
Results. After 6 months and 12 months after treatment, both groups showed a statistically significant increase in BMD in both the lumbar spine and hip neck, compared with the baseline level. At the same time, there were no differences between the increase in BMD between the two groups of patients receiving Osteostatics and Aclasta. The dynamics of the increase in BMD after 6 months and 12 months after the infusion of zoledronic acid indicates a similar effectiveness of the original and generic drugs.
Conclusion. Effectiveness of the generic preparation of zoledronic acid Osteostatics at a dose of 5 mg is comparable to the original preparation Aclasta.
A estatueta da tumba de Nakht (TT 52): o achado, o hino e as formas de Rê
Authors: Canto Núñez Pedro Hugo
Published: December 2024

A estátua de Nakht estava localizada em um nicho próprio na câmara interna da tumba de um escriba e astrônomo do deus Âmon, situada na margem ocidental de Tebas, atual Luxor. Essa estátua é um dos objetos encontrados na tumba, tinha 40cm de altura, com um homem ajoelhado segurando uma estela. Ao categorizarmos esse objeto, vemos que ele pertence ao tipo stelophor, que é baseado em uma conjuntura religiosa que une as concepções de estátua, estela e porta falsa. Nesse artigo temos o intuito de analisar a estátua de Nakht a partir da Teoria do Engajamento Material, proposta por Lambros Malafouris, elucidando a sua posição na tumba, a sua forma e o texto, de modo que possamos construir uma ideia do que esse objeto podia simbolizar dentro da crença egípcia.
Horus Niño en el mundo de los muertos. El mito en la literatura funeraria, desde el Reino Antiguo al Reino Nuevo
Authors: Hofman Bárbara
Published: December 2024

En el presente trabajo analizaremos la incorporación del relato mítico del nacimiento y primeros momentos de vida del dios-rey Horus en la literatura funeraria desde el Reino Antiguo al Reino Nuevo. Ponderaremos las formas en las que fue narrado, los grupos sociales que hicieron uso de éste y los rasgos generales de los contextos históricos en los que fue puesto en circulación. El análisis de los procesos de edición, apropiación y adaptación del episodio constituye una vía para la identifica-ción de los cambios en las concepciones simbólicas y las prácticas sociopolíticas que experimentó la sociedad egipcia en el curso de su historia. Asimismo, el uso del relato debió constituir un elemento fundamental del discurso legitimador del orden vigente en cada uno de los períodos considerados.
Hacia una teoría del arte egipcio pre-canónico
Authors: Maydana Sebastián F.
Published: December 2024

Los dos desarrollos más importantes de las últimas décadas en el campo del arte egipcio fueron la idea de canon (desarrollada por Whitney Davis) y la de decorum (término de John Baines). Tanto Baines como Davis insisten en que el estilo de figuración tan particular de los egipcios obedece a elecciones conscientes de artistas dentro de un marco cultural específico. Como parte de mi propuesta señalo que el arte del período Predinástico (ca. 3900-3200 a.C.) no cuenta con un canon, pero sí con un decoro que es propio del período, es decir, pre-canónico. Debido a la especificidad del arte del Predinástico, cuando no había en Egipto escritura, un canon estético definido ni una unidad política territorial, es necesario desarrollar una teoría del arte egipcio pre-canónico que permita abordarlo en sí mismo y no en función de los desarrollos posteriores. Esto es, no como su “fase formativa” sino como una forma particular del mismo. Propongo aquí desarrollar un herramental teórico y metodológico que nos permita ubicar las figuraciones del período Predinástico dentro de la historia del período. Me interesa llegar a construir una teoría del arte egipcio pre-canónico que sirva de plataforma a ulteriores estudios, propios y de otros investigadores del área.
Origen y materialidad de la escritura en Israel y el antiguo Egipto. Filología y arqueología en diálogo
Authors: Salvador Adriana Noemí
Published: December 2024

El contexto material donde vemos emerger los jeroglíficos egipcios y el protosinaítico alfabético que se inspira en ellos, ambos en la tierra de Egipto, se pone en relación con la materialidad fonética orgánica que tienen en común redactores y receptores del texto, como posible vía de acceso para una construcción identitaria. El contacto permanente con elementos divinizantes en las minas del Sinaí, lugar de origen para el protosinaítico, coincide con el entorno vinculado a la resurrección y vida en el Más Allá de la tumba material donde encontramos la emergencia de los jeroglíficos en el valle del Nilo. A pesar de tratarse de una lengua alfabética lineal, vemos que el corpus delimitado y autónomo del hebreo bíblico mantiene la misma versatilidad y poder creativo de los jeroglíficos. Estas convergencias son ilustradas con tres ejemplos para concluir sugiriendo la posibilidad de estudiar los orígenes e identidad de Israel tomando en consideración la creación de la escritura.
An Optimized Method for Single Cell Cloning of Human CAR-T Cells based on FBS-coated Plates
Authors: Jafari Mahdie , Abdoli Shahriyar , Moghaddam Pour Masoud , Shokrgozar Mohammad Ali , Sharifzadeh Zahra
Published: December 2024

T cell-based immunotherapy, especially chimeric antigen receptor (CAR)-T cells, has emerged as an appropriate approach for treating hematologic malignancies and is currently under investigation in clinical trials for solid tumors. Despite significant improvements in CAR-T cell production processes, the isolation and expansion of CAR-engineered T cells continue to pose significant challenges. The aim of this research is to provide a simple and cost-effective method for the isolation and expansion of human CAR-T cells. This novel concept applies coated FBS culture plates and focuses on enhancing viability and functionality to improve the adherence of suspended T cells. Methods: This study evaluated a two-dimensional (2D) culture technique for isolating the CAR-T cells that target prostate-specific membrane antigen (PSMA) utilizing matrices pre-coated with 0.2% glutaraldehyde and FBS. Jurkat cells were transduced with a lentiviral vector encoding the anti-PSMA CAR construct. FBS-coated and commercialized Matrigel-coated matrices were used for single-cell isolation and clonal expansion. Functional tests were conducted to assess the activation and proliferation of CAR-T cells and the IFN-γ release assay subsequent to cloning and expansion. Results: Transfection efficiency markedly improved, with 88.4% of Lenti-X 293T cells demonstrating GFP expression. Among the Jurkat cells, 57.1% showed GFP expression post-transduction, of which 34.1% showed surface expression of anti-PSMA CAR. Clonal expansion on the FBS-coated matrix proved effective, yielding 92.1% GFP-positive isolated cells. Functional assays demonstrated that CAR-T cells co-cultured with LNCaP cells exhibited significantly enhanced proliferation, activation (as indicated by CD69 and CD25 expression), and cytokine release assay (IFN-γ) compared with those co-cultured with DU 145 and mock cells. Conclusion: This new approach is efficient, economical, and scalable for isolating specific homogenous T cells and promoting their clonal proliferation and expansion. Future research should concentrate on optimizing culture conditions and testing this method in preclinical animal models to ensure its clinical applicability and efficacy.
Are Burned Babies and Mass Graves a Global Health Crisis? What Does Decolonization Got to Do With It? Comment on "The Rhetoric of Decolonizing Global Health Fails to Address the Reality of Settler Colonialism: Gaza as a Case in Point?"
Authors: Anonymous Anonymous
Published: December 2024

In this commentary, the author situates the article of Engebretsen and Baker in the larger history of exceptionalizing and evading Palestine in the global health literature. The political root causes for ill health in Palestine such as settler colonization, apartheid and racism are evaded and deemed "too political" and Palestinian health is flattened to the humanitarian realm, thus reinforcing Palestinian dependency on humanitarian aid, rather than subjects of Israeli necropolitics. The commentary focuses on this moment of genocide in Gaza and the importance of shifting the narrative on Palestinian health and global health more generally to focus on current imperialism, wars and settler colonialism. The commentary highlights the importance of showing moral clarity at this moment and center the Gaza Genocide in classrooms, publications and conferences rather than avoiding "controversy" and developing a moral outrage when it is no longer useful and after the smell of death has dissipated.
Political Considerations When Monitoring the Commercial Determinants of Health Comment on "National Public Health Surveillance of Corporations in Key Unhealthy Commodity Industries – A Scoping Review and Framework Synthesis"
Authors: Lacy-Nichols Jennifer , Jones Alexandra , Cullerton Katherine
Published: December 2024

Better intelligence about how commercial actors influence health and equity is crucial to advance public health policies that prioritise people over profits. The "template surveillance system" proposed by Bennett and colleagues presents a useful step towards increasing our knowledge about the practices of commercial actors and monitoring potentially harmful activities. Yet practical considerations around what sectors or commercial practices are prioritised, how we gather this intelligence, and who "owns" or funds surveillance initiatives bring to the fore political challenges with this work. Here, we reflect on our own experience researching corporate political activities (such as lobbying) to present recommendations for advancing the "template surveillance system" proposed by Bennett and colleagues.
Comparative study of intrathecal bupivacaine in combination with nalbuphine and bupivacaine for subarachnoid block in a tertiary care hospital
Authors: Bachula Lavanya , Rahul Dev Nallolla , Shiva P.V. , Cherukuri Sunil Kumar
Published: December 2024

Introduction: Various adjuvant therapies have been developed to prolong intra and postoperative analgesia. A comparative study was conducted to evaluate the onset, maximum level, and duration of motor and sensory block, as well as the duration of analgesia, side effects like hypotension, bradycardia, sedation, and respiratory depression in patients undergoing elective lower segment caesarean section (LSCS). Methods: The study included 60 patients, divided in to two groups to receive intrathecal hyperbaric bupivacaine (0.5%) in combination with nalbuphine (0.8 mg) (group A) and intrathecal hyperbaric bupivacaine alone (group B). Demographic data, onset of sensory and motor block, regression of motor block, duration of analgesia, hemodynamic changes, and side effects during the procedure were recorded. Results: A statistically significant difference was observed in time of onset of sensory and motor block, and maximum percentage of sensory block was attained in group B (bupivacaine) with 90% of patients. Mean duration of sensory regression to S1 was attained at 120.16 minutes in group A (bupivacaine+nalbuphine). Mean duration of analgesia was attained at 203.33 minutes in group A, and haemodynamic parameters have remained below the baseline value in both the groups. Side effects during the surgery were statistically insignificant. Conclusion: Intrathecal nalbuphine (0.8 mg) is an effective adjuvant to 0.5% hyperbaric bupivacaine in subarachnoid block for patients undergoing elective LSCS. It provides prolonged postoperative analgesia without much side effects and may be used as a better alternative over other opioids.
ASSESSMENT OF AGRO-INDUSTRIAL COMPLEX DEVELOPMENT IN THE SYSTEM OF SOCIO-ECONOMIC RELATIONS OF THE MUNICIPAL DISTRICT
Authors: Podmolodina Irina , Davydenko I.
Published: December 2024

The article presents an approach to assessing the development of agro-industrial complex in the system of socio-economic relations of a municipal district on the example of Khokholsky municipal district of the Voronezh region. The agro-industrial complex can act as a system-forming factor of the municipal territory and have a direct impact on the solution of socio-economic problems by activating the economic activity of the population. An important condition is the balance of such a relationship.
TRENDS AND DEVELOPMENT PROSPECTS OF THE BIOFERTILIZER MARKET IN RUSSIA
Authors: Kolesnichenko Elena , Momot Raisa
Published: December 2024

The article examines the possibilities of the prospect of meeting the increasing demand for biofertilizers. It is determined that the trend of transition to a healthy lifestyle can cause an increase in demand for organic fertilizers and organic farming in general. The authors have suggested that sewage sludge may be a source of production of organic biofertilizers. As part of the confirmation of the hypothesis put forward, the authors carried out a chemical analysis of sewage sludge, the task of which was to identify the possibility of its processing and obtaining organic fertilizers. As part of the analysis, the nature of the effect of the fertilizers obtained on agricultural crops was revealed, which, first of all, allowed us to confirm the hypothesis put forward, and secondly, to calculate the financial parameters of the project for the production of organic fertilizers from sewage sludge to justify the economic feasibility of its implementation. The basis of the economic justification was the determination of the amount of costs necessary for the implementation of each stage of the project (the preparatory stage, including the formation of sets of documentation characterizing both the design parameters of the installation and the results of a comprehensive preliminary assessment of biofertilizer; the main production stage, including the approbation of the pilot drying instance and the formation of a set of documentation for the launch of a pilot production line) with production volumes 2.5 tons / day and a sales period of 24 months. As a result, it was concluded that the developed composition of the fertilizer complies with SanPiN 1.2.3685-21 "Hygienic standards and requirements for ensuring the safety and (or) harmlessness of environmental factors for humans." The production of biofertilizer from sewage sludge can be quite successful, which was confirmed by the calculation of the economic indicators of the project (weighted average cost of capital, internal rate of return, discounted payback period, capital expenditures of the company.
DEVELOPMENT OF ORGANIC FARMING AND GREEN TECHNOLOGIES OF GRAIN PRODUCTION AS PRIORITIES FOR RUSSIA AND SIBERIAN REGIONS IN MODERN ECONOMIC CONDITIONS
Authors: Tyu L. , Shchetinina I , Edrenkina N , Shapovalov D.
Published: December 2024

Organic production is a rapidly growing global trend in the development of agri-food systems associated with the solution of problems on preservation of ecology and public health. The purpose of the study is to develop proposals for the development of organic farming in the regions of Siberia based on the development of "green" technologies in the production of crop production. The article examines the current state and problems of the development of organic farming in Russia, including in the Siberian Federal District, identifies the opportunities for the development of organic farming and "green" technologies, proposes a system of measures for the development of these technologies, including the creation of agro-industrial clusters specializing in the production of organic products. Abstract-logical, economic-statistical, monographic methods were used in the study. The proposals prepared based on the results of the study are the basis for the development of organic farming and "green" technologies of grain production in the regions of Siberia.
Life Energy By Symmetric Quartic Power Curves
Authors: Maccone Claudio
Published: December 2024

Life of a living being is mathematically modelled as a Quartic Power Curve in the time. Then we compute the Energy of Life of such an individual as a Quintic in the time. More applications of this model to real life will follow in the future: now just the basic mathematics is described in this brand-new paper.
Pro-environmental behaviors and behavioral spillover among bicycle tourists
Authors: Soyalp Levent
Published: December 2024

This study investigates various pro-environmental behaviours and their relationships among bicycle tourists. These behaviours encompass preferences for cycling and walking, energy conservation, waste separation, and environmentally friendly tourism product purchases. Additionally, the study investigates past carbon emissions due to motorised transportation as bicycle tourists and their moderating effect on indicated behaviours. According to the results obtained from structural equation modelling, the adoption of carbon-free modes of transportation for environmental purposes is significantly related to segregation, conservation, and environmentally friendly tourism product purchases among bicycle tourists. The result shows evidence of behavioural spillover among bicycle tourists. Furthermore, the study reveals that the moderating effect of past motorised transportation usage is particularly pronounced in the case of segregation behaviour. Finally, the study calculated the minimum overall carbon emissions rate for an individual by transportation and discussed potential reasons.
The impact of human capital on the load capacity factor in the middle east and north Africa
Authors: Ben-Salha Ousama , Zmami Mourad
Published: December 2024

Although there has been a substantial body of research analysing the factors influencing environmental sustainability, the role of human capital has been relatively understudied. The objective of this research is to fill this gap by examining the impact of human capital on load capacity factor (LCF) across 14 MENA countries from 1990 to 2019. The empirical investigation employs the Method of Moments Quantile Regression (MMQR) alongside a variety of second-generation panel data techniques. The empirical analysis confirms the presence of a long-term linkage between human capital and environmental sustainability. Furthermore, the MMQR suggests a negative impact of human capital on LCF across all quantile orders, indicating that enhanced human capital reduces LCF and deteriorates environmental quality. Although the detrimental effects of human capital on the environment is observed in all countries, they are more pronounced in countries with good environmental performance. Additionally, the MMQR indicates the validity of the Load Capacity Curve hypothesis within MENA countries. Finally, economic globalisation and population have detrimental impacts on the environment, whereas clean energy consumption has a positive effect. This study emphasises the necessity of increasing public awareness of environmental challenges, as well as the implementation of strategies for mitigating climate change in the MENA region.
Длительный катамнез детей с идиопатической желудочковой экстрасистолией и манифестацией в раннем возрасте
Authors: Елисеева О.В. , Кульбачинская Е.К. , Конопыхина К.А. , Березницкая В.В.
Published: December 2024

Цель. Оценить прогноз течения заболевания в долгосрочном периоде у детей с манифестацией идиопатической желудочковой экстрасистолии (ИЖЭ) в возрасте до 5 лет. Материалы и методы. В исследование включено 50 детей (26 мальчиков и 24 девочки) с ИЖЭ, которая впервые выявлена в возрасте до 5 лет включительно. Использовались клинико-анамнестический метод, ЭКГ, 24-ХМ, эхокардиография (ЭхоКГ). Обследование проводилось с периодичностью 1 раз в 6–12 месяцев. Длительность наблюдения составила в среднем 12 лет. Результаты. ИЖЭ у детей с манифестацией в возрасте до 5 лет протекает бессимптомно и характеризуется относительно благоприятным прогнозом. По результатам обследования ни у одного пациента не было усугубления аритмии и признаков аритмогенной кардиомиопатии. Полное исчезновение ИЖЭ отмечалось у 39% пациентов, снижение представленности более чем вдвое наблюдалось в 52% случаев, сохранение исходных значений – у 9% пациентов. Вероятность снижения представленности ИЖЭ при длительном катамнезе не зависела от наличия медикаментозной терапии в анамнезе (p=0,49) и локализации эктопического очага (p=0,59). Наиболее частой локализацией была свободная стенка правого желудочка под трикуспидальным клапаном (40% пациентов). Заключение. ИЖЭ с манифестацией в младшем детском возрасте характеризуется благоприятным прогнозом и в большинстве случаев не требует назначения медикаментозной терапии.

Purpose. To evaluate the long-term prognosis of idiopathic ventricular extrasystoles (IVE) initially manifested in children before the age of 5 years. Materials and methods. The study included 50 children (26 boys and 24 girls) diagnosed with IVE before the age of 5 years. Clinical and anamnestic evaluations were conducted using electrocardiography, 24-hour Holter monitoring, and echocardiography. Patients were assessed once every 6–12 months over an average follow-up period of 12 years. Results. IVE in children manifesting before the age of 5 years is typically asymptomatic and associated with a favorable long-term prognosis. No patient developed worsening arrhythmia or signs of arrhythmogenic cardiomyopathy during follow-up. The complete resolution of IVE was observed in 39% of patients, while 52% showed more than a twofold reduction in ventricular extrasystoles prevalence. In 9% of cases, the initial prevalence of ventricular ectrasystoles remained unchanged. The odds of improvement was not significantly influenced by prior drug therapy (p=0.49) or the ectopic focus location (p=0.59). The most common ectopic focus location was the free wall of the right ventricle beneath the tricuspid valve (40% of patients). Conclusion. IVE manifesting in early childhood is characterized by a favorable prognosis and generally does not require pharmacological interventions in most cases.
Особенности клинического течения вентилятор-ассоциированной пневмонии, обусловленной различными бактериальными возбудителями, у недоношенных новорожденных детей
Authors: Кушнарева М.В. , Мархулия Х.М. , Кешишян Е.С.
Published: December 2024

Цель. Определить особенности клинического течения вентилятор-ассоциированной пневмонии у недоношенных новорожденных детей, обусловленной различными бактериальными возбудителями. Материалы и методы. Под наблюдением находилось 100 недоношенных новорожденных детей с вентилятор-ассоциированной пневмонией, которые были разделены на четыре группы с учетом возбудителей заболевания: Pseudomonas aeruginosa (I группа детей), Stenotrophomonas maltophilia (II группа), Klebsiella pneumoniae (III группа) и Staphylococcus epidermidis (IV группа). Результаты. Наиболее благоприятное течение имела пневмония, вызванная K. pneumoniae, наиболее тяжелое течение с высокой частотой осложнений – пневмонии, обусловленные Ps. aeruginosa и Sten. maltophilia. Осложнения были практически у всех детей в I и II группах, в то время как в III группе – у 4 (29%) и в IV – у 5 (33%) детей. Пневмоторакс и исход в сепсис наблюдались только в I и II группах. В этих же группах отмечена высокая частота бронхолегочной дисплазии (43%), тогда как в III группе – 14% и в IV – 13%. Ателектазы встречались в 3–5 раз чаще в I и II группах, чем в III и IV. Самая высокая летальность (по 28,6%) зафиксирована в I и II группах, самая низкая (14,3%) – в III группе. Летальность в IV группе составила 20%. Заключение. Проведение дополнительных диагностических и лечебных мероприятий с учетом этиологии пневмонии позволит повысить эффективность лечения и улучшить исход заболевания.

Purpose. To determine clinical features of ventilation-associated pneumonia in premature newborns caused by various bacterial pathogens. Materials and methods. A total of 100 premature newborns with ventilator-associated pneumonia were under observation; they were divided into four groups considering the causative agents: Pseudomonas aeruginosa (Group I), Stenotrophomonas maltophilia (Group II), Klebsiella pneumoniae (Group III), and Staphylococcus epidermidis (Group IV). Results. Ventilator-associated pneumonia caused by K. pneumoniae presented the most favorable course, while pneumonias caused by Ps. aeruginosa and Sten. maltophilia had the most severe courses with a high incidence of complications. Complications occurred almost in all infants in groups I and II, while in group III they were present in 4 (29%) and in group IV in 5 (33%) infants. Pneumothorax and sepsis outcomes occurred only in groups I and II. A high incidence of bronchopulmonary dysplasia (43%) was noted in the same groups, compared with 14% in group III and 13% in group IV. Atelectasis was 3–5 times more frequent in groups I and II compared to groups III and IV. The highest mortality rate (28.6% in each) was recorded in groups I and II, the lowest one (14.3%) was in group III. The mortality in group IV was 20%. Conclusion. Carrying out additional diagnostic and therapeutic measures taking into account the etiology of pneumonia will increase the treatment effectiveness and improve the disease outcomes.
The Effect of Local Wisdom Product Design and Product Quality on Increasing Product Competitiveness of Bengkalis Batik Weaving (Case Study on Customers of BUMDes Langgam Sako)
Authors: Nursyafrika Putri
Published: December 2024

This study aims to determine the influence and how much the effect of Local Wisdom Product Design and Product Quality to Increase Product Competitiveness of Bengkalis Batik Weaving (Case study at Customer BUMDes Langgam Sako). The variables used consist of 2 independent variables and 1 dependent variable. This study uses quantitative methods using non-probability sampling method with Snowball sampling. Data collection techniques were carried out using a questionnaire to 100 consumers who have worn Batik woven BUMDes Langgam Sako. Processing data using the SPSS IBM 27 application with multiple linear regression analysis testing which include validity test, reliability test, T test, F test, and coefficient of determination (R2). The results of simultaneous testing between all independent variables on the dependent variable, it can be concluded that a local wisdom product design and product quality simultaneously have a positive and significant effect on increasing product competitiveness of Bengkalis batik weaving, and with the calculation of the coefficient of determination (R2) of 54.2% is a value that can explain product competitiveness from two independent variables, namely local wisdom product design and product quality.
Augmented reality in the educational context for the digitalization of products and mathematical applications
Authors: Del Carmen-Morales Yucels Anaí , Del Carmen-Morales Heidi , Felipe-Redondo Ana María , Juárez-Castillo Efrén
Published: December 2024

The objective of this project was to develop an application using AR augmented reality technologies for the digitalization of products and learning in educational contexts. The extreme programming (XP) methodology was used for its development which comprises the stages: planning, design, coding, testing, launch. As a result integrating Vuforia into Unity enabled the creation of augmented reality (AR) applications for mobile devices in this project was used the operating system of Android, Tests were carried out to determine how Vuforia works in Unity using Image Targets and 3D Models, an installation manual was developed for beginners to integrate their knowledge, practical problem solving, Interactivity and meaningful learning.
Optimization of preventive maintenance in the design of photovoltaic plants
Authors: Chavira-Álvarez Alberto , Pérez-Ortega Eva Claudia , Esparza-Delgado María Del Carmen
Published: December 2024

Two of the biggest problems worldwide are electrical energy and water, in this context the use of photovoltaic systems for the generation of electrical energy is increasingly profitable due to the constant reduction of prices in terms of the dollar watt and that supports the solution to the problem of energy supply at increasingly affordable prices. In this same scenario we have a reduction in CO2 emissions, contributing to the reduction of greenhouse gases, supporting the Kyoto protocol and the Paris agreement. On the other hand, the incorporation of ionized air for cleaning the photovoltaic modules allows the use of natural and demineralized water to be reduced to levels of around 98%, which allows us to be on par in saving solutions for this vital liquid.
Financial transformation through Fintech in Mexico
Authors: Jiménez-Lozano Pilar Patricia , Medina-Mora Samuel , Peña-Alvarado Erika , Pérez-Castañeda Nancy Elizabeth
Published: December 2024

In the year 2024, Fintech in Mexico have experienced significant growth and have established themselves as
important players in the country's financial sector, these platforms to carry out financial transactions, manage their
personal finances and access alternative banking services; Fintech have expanded their service offering beyond
digital payments and transfers, now offering products such as loans, insurance, investments and financial advice,
covering a wide range of users' financial needs. This research aims to provide a general overview of the use of Fintech
currently in Mexico, as well as regulation, financing, strategies, transformation, and statistical data. The methodology
used in the research is mixed because it takes up characteristics of quantitative studies, through data obtained from
different and qualitative sources in accordance with the research to be carried out rationally in data theory. Greater
investment and financing since Fintech in Mexico has attracted significant investments from both national and
foreign capital, this has allowed Fintech companies to expand, improve their technologies and offer better services
to their users. It is important to recognize that Fintech in Mexico in 2024 is at a point of maturity and growth, offering
a wide variety of digital financial services and contributing to financial inclusion and the modernization of the sector
in the country
Hunger relief, economic feasibility to establish a healthy, sustainable and community kitchen
Authors: Peña-Montes De Oca Adriana Isela , Perez-Nuño Maricela , Robles-García Francisco J.
Published: December 2024

The purpose of this work is to develop a strategic model to establish a community kitchen as an
alternative to alleviate hunger in order to address one of the challenges proposed in the sustainable
development goals by the OCDE. A methodology was developed integrating tools such as Project
Plan and PMBOK methodology in order to establish responsibilities, scope, times and resources;
acquiring or adapting existing resources, combined with the economic feasibility study, through
the application of various financial and economic instruments for this purpose, such as the Net
Present Value (NPV), the Internal Rate of Return (IRR), the Minimum Acceptable Rate
Performance (TMAR), Cash Flows, among others. The results allowed a projection to ensure the
success of the company mediating educational systems and compliance with applicable
regulations among others, to reduce risks to the company or people. Future lines of research are
proposed to evaluate mechanisms of transparency, effective and relevant accountability,
measurement of the level of satisfaction, so as to allow the evolution of the community kitchen
in harmony with the development of continuous improvement, in order to avoid dependency of
social programs
Economic and financial challenges of micro, small and medium-sized enterprises in Mexico
Authors: Serrano-Torres Ma. Guadalupe , Ruiz-Esparza Sandra , Quezada-Flores Ma. de la Luz , Zambrano Valdivieso Oscar Javier
Published: December 2024

The objective of this research is to answer the research question: Why analyze the economic and financial challenges for micro, small and medium-sized enterprises in the city of León, Guanajuato, Mexico? The type of research is mixed because it is based on grounded theory and contrasts with findings from other national and international research that speak of the economic and financial challenges of MSMEs. For the quantitative analysis, 378 surveys were applied. The results obtained show: That the director of the MIPES has the challenge of properly managing his finances, knowing what he owes and what he has. It is concluded that one of the main economic and financial challenges is not to be financed mainly by its suppliers, but to use bank loans that charge a cheaper rate. Than the price increase made by their suppliers.
¿Evaluación clínica sin antropometría? Insuficiente para tomar decisiones eficaces en un paciente ambulatorio y hospitalizado
Authors: Benjumea Rincón Maria Victoria
Published: December 2024

Editorial "¿Evaluación clínica sin antropometría? Insuficiente para tomar decisiones eficaces en un paciente ambulatorio y hospitalizado"