bluuebunny/crossref_metadata_2025 huggingface dataset:
FEATURES OF THE ANALYSIS OF FINANCIAL RESULTS OF THE ENTERPRISE ACTIVITIES IN MODERN CONDITIONS
Authors: N. Kuprina , O. Volodina , Yu. Zavatska
Published: October 2019

The article examines the approaches to the methodology of conducting financial results of theenterprise in scientific works and papers that have a practical focus, as well as in accordance with nationaland international Accounting Regulations (standards), which control the order of their formation andreflection in the financial statements.The financial results of the activity of the enterprise according to the materials of the financialstatements of the food industry enterprise for three years have been analyzed with the factor analysis ofthe financial results using the additive model. The application of the complex methodical approach to theanalysis of financial results of the enterprise activity, which covers the analysis of the composition,structure, dynamics of incomes and expenses of the enterprise, the analysis of the formation, structureand dynamics of changes in the financial results of the enterprise, both in general and by individual types,the factor analysis of the financial results formation with the use of the additive model, taking into accountthe factors of the first, second and third order, the analysis of profitability (products, prodaction, capital) ofthe company, allowing to develop increase of positive trends as fo its financial results, have been offered.
УПРАВЛІННЯ ЛОГІСТИЧНИМИ ЛАНЦЮГАМИ ПІДПРИЄМСТВ
Authors: Д. Седіков В.
Published: October 2019

Досліджуються особливості управління логістичними ланцюгами та основні напрями розвитку,роль і місце вантажного транспорту в логістичному ланцюгу руху зернових вантажів. Сформульованотенденції розвитку вантажоперевезень автомобільним транспортом зернових вантажів. Представленіосновні провайдери логістичних послуг в умовах розвитку інтеграційних процесів. Аналіз цілей і за-вдань учасників логістичного ланцюга руху зернових вантажів виявив роз’єднаність їх економічних ін-тересів та суперечності, що виникають у ході їх взаємодії. Передбачається, що реалізація запропоно-ваних напрямів з консолідації дій учасників логістичного ланцюга та використання IT-технологій вуправлінні бізнес-процесами підприємств дозволить отримати конкурентні переваги від послуг, що на-даються, підвищити їх якість, оптимізувати витрати, знизити собівартість перевезень.
CHALLENGES AND PROSPECTS FOR THE DEVELOPMENT OF SELF-GOVERNMENTS IN POST- SOVIET REPUBLICS
Authors: Chichinadze B
Published: October 2019

The article analyzes the situation with local self-government in the former Soviet republics, the path that they followed after gaining independence, information has been given on the socio-economic situation in local governments. The activities and plans of the central authorities of these countries for the nearest future have also been given. The implemented effective policy should guarantee the real development of local selfgovernment of the former Soviet republics.  After the collapse of the Soviet Union, one of the most acute problems in the post-socialist republics was the formation and strengthening of local self-government.The situation in the former Soviet states , from the point of view of the development of local self-government, is almost identical (except are the Baltic republics).
Demand relaxation in supplier selection processes
Authors: Vizzoto Felipe , Caixeta Filho José Vicente
Published: October 2019

Abstract Supplier selection processes generally evaluate several criteria in order to fulfill a demand. But, what if the demand itself could be rethought, spreading the possibilities of acquisition? What are the impacts in cost and utility of buying objectives instead of pre-determined materials? This work tries to expand this discussion with a mathematical programming approach to selecting suppliers with demand relaxation. The requirements for the framework development and application in purchasing departments are also pointed out. Its adoption in association with combinatorial auctions concepts in a hypothetical but realistic context suggests a high potential to cost reduction with no significant utility decrease.
Agreement between two Meal Quality Indexes adapted to evaluate food consumption of institutionalized elderly
Authors: GERMOGLIO Rebecca Garcia , LIMA Severina Carla Vieira Cunha , LIBERALINO Laura Camila Pereira , CABRAL Natália Louise de Araújo , LIMA Kenio Costa de , LYRA Clélia de Oliveira
Published: October 2019

ABSTRACT Objective To assess agreement between two meal quality indexes adapted for elderly people, evidencing their similarities and differences Methods Agreement study with 322 institutionalized elderly individuals. Food consumption data were collected by the method of weighted food record, in two nonconsecutive days. The Meal Quality Index and the Main Meal Quality Index of each older adult were calculated for the lunch meal. Agreement between methods was tested by cross-classification in quartiles and weighted kappa (Kw), and the difference between medians by the Wilcoxon test. Results The Meal Quality Index median was 54.67 points and the Main Meal Quality Index 53.51 points (p=0.723). When the components of each index were assessed, those associated to the consumption of carbohydrates, total fat and saturated fat were similar. The consumption of fruits separated from vegetables in the Main MealQuality Index evidenced low consumption of vegetables by the elderly. Cross-classification by quartiles showed good agreement; the exact one being 48.8% and the disagreement 3.4% (Kw=0,447). The proportion of elderlyindividuals in the same exact or adjacent quartile was greater than 85.0%. Agreement was higher in males (89.4%, Kw=0.475); in the age range of 70 to 79 years (91.1%; Kw=0.562) and in non-profit nursing homes(96.7%; Kw=0.622). Conclusion The two indexes reviewed show a good agreement between them and common characteristics. The number of components is higher in the MMQI and may represent a more detailed assessment of meal quality.
Fatores relacionados ao consumo do narguilé entre estudantes de medicina
Authors: Araújo Roseliane de Souza , Milhomem Yves de Oliveira , Pereira Henrique Falcão Silva , Silva Junior José Laerte Rodrigues da
Published: October 2019

RESUMO Objetivo Avaliar o nível de conhecimento sobre os malefícios do narguilé, a frequência e os fatores psicossociais envolvidos na sua utilização entre os estudantes de Medicina de dois diferentes períodos e sua relação com a intenção de parar de utilizar. Métodos Foram avaliados alunos do 1o e do 6o ano do curso de Medicina. Regressão logística multivariada foi utilizada para avaliar a associação entre o uso de narguilé nos últimos 30 dias com os dados demográficos, psicossociais e com o nível de conhecimento sobre seus malefícios. Resultados A taxa de experimentação e do uso atual de narguilé foi elevada (59,6% e 27,7% respectivamente), sem diferença entre os grupos. O nível de conhecimento dos alunos do 6o ano acerca dos malefícios do uso de narguilé foi maior em relação aos alunos do 1o ano (p<0,0001), e não houve relação do consumo de narguilé nos últimos 30 dias com o nível de conhecimento. O tabagismo de cigarros e o uso de bebida alcoólica estavam associados ao uso de narguilé nos últimos 30 dias. Odds Ratio não ajustada de 11,3; IC95% 4,62-27,7; p<0,0001 e OR 8,74; IC95% 3,78-20,2; p<0,0001; respectivamente. Conclusões Há uma elevada experimentação, uso atual de narguilé e de cigarros entre os estudantes de Medicina, que possuem maior conhecimento sobre o malefício do uso no 6° ano do curso. Não foi observada relação entre o conhecimento sobre o malefício do uso e o consumo. O tabagismo e o uso de bebidas alcoólicas são preditores independentes de uso de narguilé.
Pontos de corte da função pulmonar e capacidade funcional determinantes para sarcopenia e dinapenia em pacientes com DPOC
Authors: Mansour Kamila Mohammad Kamal , Goulart Cássia da Luz , Carvalho-Junior Luiz Carlos Soares de , Trimer Renata , Borghi-Silva Audrey , Silva Andréa Lúcia Gonçalves da
Published: October 2019

RESUMO Objetivo Estabelecer ponto de corte entre as variáveis clínicas e funcionais para avaliar a prevalência de sarcopenia e dinapenia em pacientes com Doença Pulmonar Obstrutiva Crônica (DPOC), além de analisar o impacto da Disfunção Muscular Esquelética (DME) nestas variáveis. Métodos Realizado estudo transversal com pacientes diagnosticados com DPOC para determinar sarcopenia ou dinapenia por meio do índice de baixa massa muscular e Força de Preensão Palmar (FPP). Avaliadas a função pulmonar, força muscular respiratória e capacidade funcional (CF). A precisão das variáveis na determinação dos pontos de corte previstos para as doenças em questão foi obtida a partir da curva Receiver Operating Characteristic (ROC) e de uma análise bidirecional da variância. Resultados Ao final da análise, obtiveram-se 20 pacientes com DPOC estratificados por sarcopenia (n = 11) e dinapenia (n = 07). O grupo com sarcopenia apresentou menor massa magra e menor pressão inspiratória máxima (PImáx), diminuição da Força de Preensão Palmar (FPP) e redução da CF (p<0,050). O grupo com dinapenia apresentou redução da PImáx, menor FPP e menor distância percorrida no teste Incremental Shuttle Walk (ISWT) (p<0,050). Foram encontrados pontos de corte no Volume Expiratório Forçado (VEF1) durante o primeiro segundo na PImáx, na Pressão Expiratória Máxima (PEmáx) e no ISWT, o que possibilitou identificar sarcopenia ou dinapenia nestes pacientes. A partir destes resultados, foi possível encontrar coexistência das condições (efeito DME) na DPOC: redução da distância no ISWT (p = 0,002) e % ISWT (p = 0,017). Conclusões Em pacientes com DPOC moderada a muito grave, a sarcopenia pode ser prevista pelo VEF1 (% previsto) <52, PImáx <73 cm H2O, PEmáx <126 cm H2O e distância percorrida de <295 metros no ISWT. Já a dinapenia pode ser prevista pelo VEF1 <40%, PImáx <71 cm H2O, PEmáx <110 cm H2O e distância de <230 metros percorrida no ISWT.
Determination of heart rate threshold from heart rate kinetics during maximal graded exercise in soccer players
Authors: Marques Neto Silvio Rodrigues , Lattari Eduardo , Gurgel Alexandre , Faleiro Viviane , Machado Sérgio , Farinatti Paulo , Maranhão Neto Geraldo
Published: October 2019

Abstract The main of the present study was to identify the heart rate threshold based on heart rate kinetics during graded maximal exercise in football players. Twenty-six male football players performed a maximal exercise test (Bruce protocol) on a motor-driven treadmill. Oxygen uptake (VO2) and heart rate (HR) were monitored, recorded and resampled at 3.5Hz. The ventilatory threshold (VT), and respiratory compensation (RC), heart rate deflection points (HRDP1 and HRDP2) and heart rate kinetics threshold (HRT) were determined by computerized methods. The heart rate variability (HRV) was assessed in the frequency domain. The HRT averaged 89.9 ± 1.2 % of the VO2 peak. The HRT showed poor correlations and significant differences compared with HRDP1 (r = 0.46) and VT (r = 0.51), but was not different from, and highly correlated with, HRDP2 (0.98) and RC (0.90). Bland Altman plots showed all athletes into 95% of limits of agreement, and intraclass correlation coefficient showed good agreements between points obtained from HRT compared with HRDP2 (0.96) and RC (0.98). The HRT was highly correlated with HRDP2 and RC, suggesting it could be a marker for cardiorespiratory fatigue.
Sorption and Desorption of Tembotrione and its Metabolite AE 1417268 in Soils with Different Attributes
Authors: FARIA A.T. , FIALHO C.A. , SOUZA M.F. , FREITAS N.M. , SILVA A.A.
Published: October 2019

ABSTRACT: Tembotrione is registered in Brazil for maize and is used in large areas of the country in each harvest. In recent years, producers have reported carryover effects of this herbicide in succeeding crops to maize. This fact can be attributed to tembotrione recommendations without knowing their interactions with tropical soils colloids. In this study, using high-performance liquid chromatography, it was possible to evaluate the influence of chemical and physical attributes on the sorption and desorption of tembotrione, as well as its metabolite AE 1417268, on seven soils from different regions of Brazil. The coefficients referring to sorption and desorption, as well as the hysteresis index (Kf, 1/n and H) of tembotrione and its metabolite were influenced by pH, clay content and organic matter. In soil samples with low levels of clay and organic matter, values of sorption coefficients were reduced as pH increased. The desorption of tembotrione and its metabolite in all soils were low, mainly in the clayey ones and in soils with higher organic matter content. The sorption of tembotrione and its metabolites varies with the attributes of soil, presenting a direct relation with clay and organic matter contents and an inverse one with soil pH. The desorption of tembotrione and its metabolite decreased with the increase in clay and organic matter contents in the evaluated soils.
Chemical Management of Broadleaf Buttonweed and Brazilian Pusley in Different Application Methods
Authors: GALLON M. , TREZZI M.M. , PAGNONCELLI JR F.B. , PASINI R. , VIECELLI M. , CAVALHEIRO B.M.
Published: October 2019

ABSTRACT: Increased use of glyphosate in transgenic soybean areas has selected resistant and tolerant weed species. The aim of this study was to evaluate chemical management strategies for controlling Borreria latifolia and Richardia brasiliensis at pre-emergence (Pre), early post-emergence (Poste) and late post-emergence (Postl). Six experiments were carried out in a completely randomized design with four replicates per treatment in the Pre experiments and three in the Poste and Postl experiments, for each of the species. In the Pre experiments, tests were performed with herbicides imazethapyr, sulfentrazone, chlorimuron, diclosulam, S-metolachlor and saflufenacil. In the Poste experiments, seedlings were sprayed with herbicides bentazon, fomesafen, lactofen, flumioxazin and glyphosate. In Postl experiments, adult plants received glyphosate application associated with herbicides 2,4-D, carfentrazone, imazethapyr, flumiclorac, flumioxazin, sulfentrazone, chlorimuron, saflufenacil and glufosinate, plus three sequential applications with glyphosate only and paraquat/diuron. In the experiments, there was a control treatment without application of herbicides. In the Pre experiments, the plants established at 14 and 28 days after application (DAA) were evaluated. In the Poste and Postl experiments, shoot dry matter evaluation and visual control were performed at 14 and 28 DAA. The herbicides sulfentrazone, S-metolachlor and saflufenacil suppressed the emergence of both B. latifolia as R. brasiliensis; chlorimuron-ethyl and diclosulam were effective only on R. brasiliensis. In Poste, fomesafen, lactofen and flumioxazin reached levels of control over 90% of plants of both species. In Postl, glyphosate associated with carfentrazone, flumiclorac, flumioxazin, chlorimuron-ethyl, saflufenacil, glufosinate, and sequential applications of glyphosate/glyphosate, glyphosate/paraquat+diuron, glyphosate+2,4-D/paraquat+diuron reached levels control higher than 95%.
Weed Phytosociology in Cassava Cultivation in Two Periods in Southwestern Bahia, Brazil
Authors: PRATES C.J.N. , VIANA A.E.S. , CARDOSO A.D. , SÃO JOSÉ A.R. , VIANA B.A.R. , DUTRA F.V.
Published: October 2019

ABSTRACT: Knowing the most important species in the weed community is necessary to decide the best weed control method to be used. Thus, a phytosociological survey was carried out on cassava cultivation areas located in five rural properties of Cândido Sales, BA, Brazil, one of the state’s largest cassava producers. Two collections were carried out in each property in February (summer) and August (winter) 2016. A square metal frame with 0.25 m2 was randomly placed in each area, zigzagging, and establishing a proportion of 25 castings per hectare, with a sampling area of 6.25 m2 in each area. Weeds were identified and quantified, and then phytosociological parameters of frequency, density, abundance, relative frequency, relative density, relative abundance, and importance value index were determined. The analysis of the similarity between populations of the areas and periods was determined by the Sorensen similarity index. A variation of weed community composition was observed between cassava and harvest periods, with a higher infestation in the summer. A similarity was observed between cassava cultivation areas.
Control of ALS- and EPSPS-Resistant Amaranthus palmeri by Alternative Herbicides Applied in PRE- and POST-Emergence
Authors: GONÇALVES NETTO A. , NICOLAI M. , CARVALHO S.J.P. , MALARDO M.R. , LÓPEZ-OVEJERO R.F. , CHRISTOFFOLETI P.J.
Published: October 2019

ABSTRACT: The emergence of resistant biotypes of the Amaranthus palmeri species in cotton production areas of the state of Mato Grosso, Brazil, generated the need for correct identification of this species and information on viable herbicidal tools for their management. Thus, greenhouse experiments were conducted to evaluate the efficacy of alternative herbicides applied to A. palmeri in pre and post emergence. A randomized block design with four replications was used. The efficacy of herbicides applied in pre emergence was evaluate in two experiments, one in a clayey and other in a sandy soil; 9 herbicide treatments (8 with herbicide application and a control without application) were applied on each soil. Subsequently, two experiments with different populations of A. palmeri were conducted, using a 13 x 2 factorial arrangement, to evaluate the efficacy of herbicides applied in post emergence. The factors consisted of 13 herbicide treatments (12 with herbicide application and a control without application) and two weed development stages (2-4 and 6-8 leaves). Pre-emergence application of the flumioxazin, S-metolachlor, isoxaflutole, and trifluralin herbicides controlled the weed satisfactorily in both evaluated soils. The sulfentrazone and metribuzin herbicides were effective in the sandy soil, and diuron was effective in the clayey soil. The clomazone herbicide did not successfully controlled the A. palmeri plants in any of the soils. All post-emergence herbicide treatments were effective for the management of A. palmeri plants, when they were applied at the 2-4 leaf stage.
A prática de ensino supervisionada em Portugal: vozes e posicionamentos do(as) estudantes-estagiários(as)
Authors: Gonçalves Carolina , Tomás Catarina
Published: October 2019

Resumo Neste artigo, propõe-se analisar as concepções de 115 estudantes que frequentam os mestrados de formação de educadores(as) de infância e professores(as) do 1° e do 2° ciclo do ensino básico, em Portugal continental, procurando perceber o que pensam e como se posicionam em relação à prática de ensino supervisionada (PES). Metodologicamente, o inquérito por questionário aplicado é a referência empírica central e os resultados permitem identificar seis dimensões relativamente à PES: i) os significados atribuídos; ii) os modelos pedagógicos ou curriculares privilegiados; iii) as áreas científicas e referenciais de suporte; iv) as reflexões escritas; v) os pontos fortes e pontos fracos; e vi) as propostas de alteração à PES no atual plano de estudos. Os resultados possibilitam desenhar um retrato que é simultaneamente marcado pela cristalização – no que diz respeito aos referenciais teóricos mobilizados pelos(as) estudantes nas suas reflexões sobre a PES, à coexistência de modelos pedagógicos ou curriculares híbridos, inexistentes ou desvalorizados e à permanência do duo psicologia e pedagogia, na sua versão clássica, sem que se mobilizem outra áreas de conhecimento – e pela descristalização – no que diz respeito ao reconhecimento do lugar central que a PES ocupa na sua formação profissional, pela mobilização da fundamentação teórica que a maioria dos(as) estudantes afirma convocar aquando da realização das reflexões escritas e a estarem conscientes acerca do que precisam para um desenvolvimento efetivo da profissionalidade docente.
Criterios asumidos por profesores cuando argumentan sobre la creatividad matemática
Authors: Seckel María José , Breda Adriana , Sánchez Alicia , Font Vicenç
Published: October 2019

Resumen El propósito de este estudio fue identificar cuáles son los criterios asumidos por profesores en ejercicio cuando argumentan sobre el desarrollo de la creatividad en los procesos de enseñanza y aprendizaje de las matemáticas. Para ello, se analizó el discurso de 35 profesores estudiantes de másters en Educación Matemática de tres universidades chilenas. Los datos, con enfoque metodológico mixto, se recogieron a partir de un cuestionario de preguntas cerradas y abiertas. Las preguntas cerradas se enfocaron en cuatro ámbitos: 1) creatividad matemática y procesos creativos; 2) creatividad en el ámbito profesional; 3) creatividad en las matemáticas; y 4) promoción de la creatividad en la enseñanza y aprendizaje de la matemática. Para el análisis de preguntas abiertas, donde los profesores presentaron un ejemplo de actividad matemática creativa y destacaron lo creativo de ella, se consideraron como categorías de análisis los Criterios de Idoneidad Didáctica (CI) propuestos en el Enfoque Ontosemiótico de la Instrucción y Cognición matemática (EOS). Los resultados muestran, entre otros aspectos, que los profesores tienen una visión dual respecto a la creatividad matemática (por una parte, es innata y, por otra parte, puede ser enseñada) y que, cuando argumentan sobre ella, utilizan de manera implícita criterios epistémicos, mediacionales, emocionales y ecológicos.
Intensified Liquid-Liquid Extraction Technologies in Small Channels: A Review
Authors: Angeli Panagiota , Ortega Eduardo Garciadiego , Tsaoulidis Dimitrios , Earle Martyn
Published: October 2019

Solvent extraction is a key separation process in several industries. Mixer-settlers and agitated or pulsed columns are mainly used as liquid-liquid contactors. However, these units require large solvent inventories and long residence times, while flow fields are often not uniform and mixing is poor. These drawbacks can be overcome with process intensification approaches where small channel extractors are used instead. The reduced volumes of small units in association with the increased efficiencies facilitate the use of novel, often expensive, but more efficient and environmentally friendly solvents, such as ionic liquids. The small throughputs of intensified contactors, however, can limit their full usage in industrial applications, thus robust scale-up strategies need to be developed. This paper reviews promising intensified technologies for liquid-liquid extractions based on small channels. In particular, extractions in single channels and in confined impinging jets are considered. The increase in throughput via scale-out approaches with appropriate manifolds is discussed, based on the use of many channels in parallel. The combination of small channels and centrifugal forces is exploited in counter-current chromatography (CCC) systems where many mixing and settling steps are combined within the contactors. Scale up is possible via centrifugal partition chromatography (CPC) configurations.
Treatment of Pediatric Glioblastoma with Combination Olaparib and Temozolomide Demonstrates 2-Year Durable Response
Authors: Valiakhmetova Andge , Gorelyshev Sergey , Konovalov Alexander , Trunin Yuri , Savateev Alexander , Kram David E. , Severson Eric , Hemmerich Amanda , Edgerly Claire , Duncan Daniel , Britt Nicholas , Huang Richard S.P. , Elvin Julia , Miller Vincent , Ross Jeffrey S. , Gay Laurie , McCorkle Joshua , Rankin Andrew , Erlich Rachel L. , Chudnovsky Yakov , Ramkissoon Shakti H.
Published: October 2019

For pediatric patients with high-grade gliomas, standard-of-care treatment includes surgery, chemotherapy, and radiation therapy; however, most patients ultimately succumb to their disease. With advances in genomic characterization of pediatric high-grade gliomas, the use of targeted therapies in combination with current treatment modalities offer the potential to improve survival in this patient population. In this report, we present the case of a 3-year-old girl with glioblastoma who continues to experience an exceptional and durable response (>2 years) to the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib. Our patient presented with persistent and progressive seizure activity that upon workup was the result of a large heterogeneously enhancing, mixed cystic and solid mass in the left frontal-parietal-temporal region. Histopathologic analysis of resected tumor tissue confirmed the diagnosis of glioblastoma, and comprehensive genomic profiling demonstrated absence of any BRAF or H3F3A mutations. Genomic profiling, however, did reveal a probable germline heterozygous BRCA2 Lys3326Ter (K3226*) nonsense variant. After debulking surgery, the patient received standard-of-care treatment with radiation and temozolomide. Nine months later the PARP inhibitor olaparib was administered in combination with temozolomide for 16 cycles. This regimen was well tolerated by the patient and serial imaging showed reduction in tumor size. Since completion of the regimen, the patient remains neurologically intact with no evidence of tumor recurrence. To our knowledge, this represents the first case of a pediatric glioblastoma that maintains a durable response to a therapeutic strategy that included the PARP inhibitor olaparib and more generally highlights the potential clinical utility of incorporating these agents into the treatment of pediatric high-grade gliomas.

Key Points

Germline mutations detected in pediatric gliomas may represent a cancer predisposition syndrome. Integrating molecular testing into routine clinical care for pediatric patients with glioma is critical to identify therapeutic targets and patients with a cancer predisposition syndrome. Patients with glioma with defects in DNA repair pathway components (e.g., BRCA1/2) may show increased responsiveness to poly (ADP-ribose) polymerase (PARP) inhibitors. Combining PARP inhibitors with temozolomide (standard-of-care treatment) revealed no adverse events or toxicities over the course of 18 months.
Tackling the energy efficiency gap in the Irish residential sector
Authors: O'Callaghan Andrew , Purcell Karl , Hemmingway Phil
Published: October 2019

The residential sector holds significant potential for improvements in energy efficiency in Ireland. Retrofit activity, however, can be difficult to instigate despite the presence of government incentives and cost-effective investment opportunities. The failure of individuals and organisations to invest in cost-effective energy efficiency measures is often referred to as ‘the energy efficiency gap’. Here, two separate, but not mutually exclusive, potential contributing factors for this phenomenon are discussed in detail: behavioural anomalies and modelling miscalculations. The relevance of these factors in the context of the Irish residential sector is introduced, and this is followed by a review of intervention literature seeking to increase energy efficiency programme adoption rates by addressing behavioural failures. An examination of domestic and international evidence shows a consistent overestimation by ex-ante models of energy-saving benefits. The paper concludes that addressing behavioural and informational factors can have a positive influence on energy efficiency adoption, but this needs to be complemented with additional policy measures to sufficiently rectify current low rates of uptake in the Irish residential sector. Simultaneously, further action will be needed to better calibrate engineering models using data gathered from ex-post field experiments.
Repensando o direito autoral: o compartilhamento de arquivos online como direito de acesso à cultura
Authors: Oliveira Amanda Muniz , Rodrigues Horácio Wanderlei , Silva Ricardo Rovilson da
Published: October 2019

O compartilhamento de arquivos online, de forma gratuita e ilimitada, é, por vezes, cerceado em razão das legislações referentes aos Direitos do Autor. Uma vez que esta prática é utilizada – sobretudo - para disseminação cultural, indaga-se se tal compartilhamento não seria uma manifestação do Direito de Acesso à Cultura. Para tanto, analisar-se-á o conceito de cultura, bem como as legislações que a definem como direito humano e lhe garantem acesso; em contrapartida, procurar-se-á demonstrar que o compartilhamento gratuito de arquivos não gera prejuízo ao Autor da obra, podendo, inclusive, lhe trazer benefícios.
Avanços da comunidade européia no direito de propriedade intelectual e indústria 4.0: extraterritorialidade e aplicabilidade do direito comparado no Brasil
Authors: Soares Marcelo Negri , Kauffman Marcos Eduardo , Sales Gabriel Mendes de Catunda
Published: October 2019

O artigo visa fornecer uma avaliação crítica sobre direito intelectual e Indústria 4.0, problematizando como a adoção generalizada de novas tecnologias digitais (Big Data Analytics, Internet of Things, sistemas robóticos, inteligência artificial e etc.) pode afetar a formulação do direito e resultar em novos entendimentos, sobretudo com relação à tutela de direitos de propriedade intelectual. Adota-se a metodologia hipotético-dedutiva a partir de pesquisa bibliográfica e do acórdão da Corte de Apelação do Reino Unido (caso nº B2/2013/1812), sobretudo no sentido de analisar os avanços na Europa e no sistema inglês, que demonstram uma maior velocidade de resposta para novos problemas na proteção de dados, sugerindo-se, ao final, a aplicação do direito comparado no Brasil em situações de omissão legislativa, enquanto não haja legislação específica, com base nos usos e costumes globalizados.
Migração, cidadania e direitos fundamentais na tríplice fronteira
Authors: Cardozo Oliveira Francisco , Biacchi Gomes Eduardo , Brandalise Gonçalves Ane Elise
Published: October 2019

O presente trabalho visa ao estudo das migrações e dos correlatos direitos fundamentais devidos sob o olhar da Tríplice Fronteira e de sua vivacidade em termos de cultura e identidade. Para tanto, duas ideias centrais são explanadas no artigo, quais sejam: (a) a normatividade dos direitos de cidadania na região da Triplice Fronteira deve considerar os desdobramentos da realidade socioeconômica, das relações sociais no território, do encontro com o outro e da interação de culturas, sem que a fusão, a mistura de relações, de visões e de sinais seja visto como algo negativo; (b) a proteção dos direitos de cidadania das pessoas na Triplice Fronteira se desdobra a partir da configuração material dos conflitos em torno da luta por reconhecimento de direitos de migrantes. Para tanto, o artigo apresenta, em um primeiro instante, a questão de territórios e fronteiras; a realidade socioeconômica da região da Tríplice Fronteira e, por fim, estuda o reconhecimento dos direitos fundamentais aos migrantes da região. O trabalho utilizou-se de um método multidisciplinar, cunhado não só pelo Direito, mas também por meio de outras áreas do saber (com destaque para Antropologia, Economia e Relações Internacionais).
Ideación suicida y estrategias de afrontamiento frente al embarazo precoz en un hospital de Lima Metropolitana
Authors: Hilaquita Cruz Gerson , Palacios Ponce de León Yomira , Herrera Blancas Rocío Evelin
Published: October 2019

Objetivo: Determinar la relación entre ideación suicida y estrategias de afrontamiento frente al impacto del embarazo en adolescentes de un hospital nacional de Lima Metropolitana. Material y Métodos: Se utilizó un diseño no experimental, de corte transversal y alcance correlacional. Se llevó a cabo en un grupo de 140 adolescentes gestantes entre 13 y 18 años. Los instrumentos usados fueron la Escala de Ideación Suicida (SSI) de Beck, adaptada en el Perú por Eugenio y Zelada (2011) y la Escala de Afrontamiento para Adolescentes (ACS) de Frydenberg y Lewis (2000). Resultados: Los resultados obtenidos demuestran que existe una relación negativa altamente significativa entre ideación suicida y quince de las estrategias de afrontamiento (rho=-0.562**p<0.05). Conclusiones: Por lo tanto, se concluye que a mayor uso de las estrategias de afrontamiento, menor riesgo de ideación suicida y viceversa.
In vitro toxicity model: Upgrades to bridge the gap between preclinical and clinical research
Authors: Madorran Eneko , Stožer Andraž , Bevc Sebastjan , Maver Uroš
Published: October 2019

The Centers for Disease Control and Prevention (CDC) provides extensive data that indicate our need for drugs to maintain human population health. Despite the substantial availability of drugs on the market, many patients lack specific drugs. New drugs are required to tackle this issue. Moreover, we need more reliable models for testing drug toxicity, as too many drug approval failures occur with the current models. This article briefly describes various approaches of the currently used models for toxicity screening, to justify the selection of in vitro cell-based models. Cell-based toxicity models have the best potential to reliably predict drug toxicity in humans, as they are developed using the cells of the target organism. However, currently, a large gap exists between in vitro cell-based approach to toxicity testing and the clinical approach, which may be contributing to drug approval failures. We propose improvements to in vitro cell-based toxicity models, which is often an insight approach, to better match this approach with the clinical homeostatic approach. This should enable a more accurate comparison of data between the preclinical as well as clinical models and provide a more comprehensive understanding of human physiology and biological effects of drugs.
Проблемы создания государственных резервов в целях обеспечения продовольственной безопасности в переговорах ВТО
Authors: Цуканова Татьяна Владимировна
Published: October 2019

Анализируются различные вопросы многостороннего регулирования торговли сельскохозяйственными товарами: обязательства РФ в отношении сельскохозяйственных субсидий, текущее состояние и перспективы Дохинских переговоров по сельскому хозяйству, регулирование ВТО и вопросы продовольственной безопасности в развивающихся странах.
Программы РФ по поддержке промышленного экспорта: некоторые наблюдения
Authors: Полуэктов Александр Борисович
Published: October 2019

За последние несколько лет в России принято свыше 20 различных нормативных документов, нацеленных на развитие промышленного потенциала страны и диверсификацию ее экспорта. Среди этих документов Энергетическая стратегия до 2030 года, принятая в 2009 г., Стратегия развития черной металлургии, Стратегия развития цветной металлургии, Стратегия развития IT-отрасли, Транспортная стратегия, Стратегия развития пищевой и перерабатывающей промышленности.
Breast tumours dissociation v1
Authors: El Ghamrasni Samah
Published: October 2019

A protocol designed to dissociate fresh breast tissues (surgical specimens and biopsies) for single-cell RNAseq. The protocol has been demonstrated to work successfully with fresh and cryopreserved tissues.
Nuclei-seq v1
Authors: Xu Mandy , Ketela Troy
Published: October 2019

This protocol has been developed by the Princess Margaret Genomics Centre specifically for Nuc-Seq, both at the bulk and single-cell levels.
Fabrication of Microneedle Patches v2
Authors: Konstantinidi Stephania , Samet Hana
Published: October 2019

The goal is to create a microneedle. patch, which, by applying it on a leaf, will extract amplification-ready DNA. All MN patches used for DNA extraction were fabricated using polydimethylsiloxane molds. These molds were fabricated by laser ablation, and the dimension of each mold is approximately 10 mm × 10 mm, which has 15 × 15 arrays of microneedle conical cavities. The height of each cavity is 800 μm, and the diameters of the tip and base are 10 and 300 μm, respectively.
Golden Gate lvl 0 v1
Authors: Seiler Vinca , Inckemann René
Published: October 2019

Golden Gate reaction protocol for lvl 0
Production of Recombinant EnvA Rabies Virus v2
Authors: Institute for Brain Science Allen
Published: October 2019

This protocol is used for the large-scale production of EnvA-pseudotyped recombinant rabies virus.
Eğitim Kurumalarındaki Örgütsel Sinizmin Cinsiyet Açısından İncelenmesi: Bir Meta-Analiz Çalışması
Authors: ÇELİK Osman Tayyar , AKAR Hüseyin
Published: October 2019

Bu
çalışmanın amacı, Türkiye'deki eğitim örgütlerinde görev yapan eğitim
çalışanlarının yaşadığı örgütsel sinizmin cinsiyete göre
farklılaşıp/farklılaşmadığını meta-analiz yöntemiyle incelemektir. Bu kapsamda,
bazı anahtar kavramlar kullanılarak yapılan literatür taramasında; 2000-2018
yılları arasında Türkiye'deki eğitim örgütlerinde yapılmış olan ve örgütsel
sinizmi inceleyen 159 çalışmaya ulaşılmıştır. Bu çalışmalardan 42'si
araştırmacılar tarafından belirlenmiş olan dâhil edilme kriterlerine uygun olduğu
için araştırmaya dâhil edilmiştir. Yayın yanlılığı, Huni Grafiği, Duval ve
Tweedie'nin kırp ve doldur yöntemi ve Egger Testi ile incelenmiş ve yapılan
testler sonucunda yayın yanlılığın olmadığı anlaşılmıştır. Analizler rastgele
etkiler modeline göre yapılmış olup, etki büyüklükleri Cohen'nin d'sine göre
hesaplanmıştır. Yapılan analizler sonucunda eğitim çalışanlarının yaşadığı
örgütsel sinizmin cinsiyete göre etki büyüklüğünün önemsiz düzeyde ve anlamsız
olduğu sonucu elde edilmiştir [d=.028; p˃.05]. Moderatör analizi sonucunda;
yayın türü, araştırmanın yapıldığı bölge ve örneklem grubunun hesaplanan etki
büyüklüğü üzerinde moderatör etkiye sahip olmadığı görülmüştür.
Fermi's Paradox and Restraint Orders: Why does no one respond?
Authors: Serpa Nilo
Published: October 2019

The persistent silence of cosmic immensity despite our efforts to communicate with possible extraterrestrial intelligences has reaffirmed an intriguing paradox in face of the logically estimated chances of intelligent life outside Earth. However, this paradox may not be exactly a contradiction, but an appearance arising from the reality of our universe. Bearing in mind that skepticism is a fundamental element of the scientific purpose, this paper describes the system of reasons why extraterrestrial contacts are very unlikely, even though intelligent life may be a relatively common fact everywhere.

Key words: Intelligent life, Fermi's Paradox, extraterrestrial contact

====================================================================

O persistente silêncio da imensidão cósmica a despeito dos nossos esforços de comunicação com possíveis inteligências extraterrestres tem reafirmado um intrigante paradoxo diante das chances logicamente estimadas de existência de vida inteligente fora da Terra. Entretanto, esse paradoxo pode não ser exatamente uma contradição, mas uma aparência decorrente da própria realidade do nosso universo. Tendo em mente que o ceticismo é um elemento fundamental da atitude científica, o presente artigo descreve o sistema de razões que tornam pouco provável um contato extraterrestre, mesmo que a vida inteligente seja um fato relativamente comum em toda parte.

Palavras-chave: Vida inteligente, Paradoxo de Fermi, contato extraterrestre

 
GENÇLİK ŞİDDETİ KONUSUNDA SON ON YILDA ÜLKEMİZDE YAPILMIŞ LİSANSÜSTÜ TEZLERİN TEMATİK AÇIDAN DEĞERLENDİRİLMESİ
Authors: Nair Güney
Published: October 2019

Toplumlar açısından gelecek
garantisi olan gençlik, dinamik iş gücünü, sürekliliği ve toplumsal
bütünleşmeyi temsil etmektedir. Ergenliği de içinde barındıran bu evrede genç
bilişsel, fiziksel ve duygusal bir değişim içindedir. Gençlik, insan yaşamında
çocukluk üzerinde şekillenir, yetişkinlik dönemi üzerinde iz bırakan bir sosyal
kategori, dinamik bir evredir. WHO tarafından dünya toplumlarının öncelikli
sorunları arasında gösterilen gençlik şiddeti geniş kitleleri etkilemekte, ağır
sosyo-ekonomik maliyetler yaratmakta ve biçimleri açısından giderek
çeşitlenmekte, farklı olaylarla dünya gündeminde yer etmektedir.

Şiddet
konusunda ülkemizde yapılan araştırmalar daha çok, aile içi, kadına yönelik,
çocuğa yönelik, çeşitli meslek gruplarına yönelik ya da sporda şiddet
konularında yoğunlaşmakta üniversite enstitülerimizin çeşitli ana bilim
dallarında farklı disiplinlerin bakış açısıyla irdelenmektedir. Türkiye’de
gençlik şiddeti konusunda yapılan akademik çalışmalar artış göstermekle
birlikte konunun yeterince ele alındığını söylemek güçtür.

Bu çalışmaya
ülkemiz üniversitelerinde gençlik şiddeti konusunda son on yılda (2008-2018)
yapılmış lisanüstü (tıpta uzmanlık, sanatta yeterlik, yüksek lisans, doktora)
araştırmalar konu edilmektedir. Araştırmada literatür taraması tekniği
kullanılarak, Yüksek Öğretim Kurulu’nun ulusal tez merkezinde kayıtlı “şiddet”
içerikli tezlere ulaşılmış, gerekli değerlendirme ve sınıflamalardan sonra
tematik incelemeyle elde edilen bulgular ortaya konarak, gelecekte yapılacak
araştırmalara yol gösterici olunması amaçlanmıştır.
NEOLİBERAL TEORİ EKSENİNDE KÜRESELLEŞMENİN TÜRKİYE’NİN ENERJİ POLİTİKALARI ÜZERİNDEKİ ETKİLERİ: ENERJİ TİCARETİ BOYUTU
Authors: Furuncu Yunus , Akbaş Zafer
Published: October 2019

Enerji kaynakları, dünya politikasına
yön veren, hatta ülke sınırlarının yeniden çizilmesinde ciddi rol oynayan
önemli bir güçtür. Çalışmada Neoliberal teori ekseninde küreselleşmenin
Türkiye’nin enerji politikalarının belirlemesine nasıl etkiler yaptığı üzerine
durulmuş ve Neoliberal teorinin uluslararası aktörler arasında ticaretin
öncelenmesi savının Türkiye özelinde enerji ticareti ekseninde ele alınması
küreselleşmenin etkisinin saptanması bakımından en önemli dayanak kabul
edilmiştir.

Çalışmada Türkiye’nin jeopolitik
konumundan hareketle, enerji ticareti alanında sözü sıklıkla dile getirilen
sadece bir köprü olmak değil, aynı zamanda “Merkezlerden Biri” olma ihtimalinin
bulunduğu iddia edilmiştir. Bunun dayanaklarının TANAP, Türk Akımı, Irak
petrollerinin Türkiye üzerinden dünya piyasalarına açılması, Türkiye’de enerji
borsasının oluşturulması gibi proje ve girişimler olduğu dile getirilmiştir.
Çalışmada Türkiye’nin enerji bağımlılığından kurtulmasıyla, ekonomik ve politik
bakımdan bölgesel güç olma yolunda büyük bir imkâna sahip olacağı; bunun
gerçekleşmesi halinde de bölgesel ve küresel barış ve istikrara büyük bir katkı
yapacağı sonucuna ulaşılmıştır.

Çalışmada Türkiye üzerinden boru
hatlarıyla geçerek dünya piyasalarında satışa sunulan petrol ve doğal gazın
Türkiye’ye getirisinin oldukça düşük olduğu görülmüştür. Bu yüzden Türkiye’nin
bu boru hatları projelerinde sadece geçiş ülkesi olmaması, aynı zamanda enerji
projelerinin büyük ortaklarından birisi olması sonucunda Türkiye’yi enerji üssü
haline geleceği; bölgesel enerji rolünü kuvvetlendireceği sonucuna varılmıştır.
TÜRKÇE ÖĞRETMENİ ADAYLARININ MOBİL İLETİŞİM ALIŞKANLIKLARI: WHATSAPP ÖRNEĞİ
Authors: Maden Aslı
Published: October 2019

Mobil
mesajlaşma uygulamalarından WhatsApp bugün yoğun biçimde kullanılmaktadır. Bu
durum bireylerin okuryazarlık becerilerini, yazarak ve konuşarak iletişim kurma
eylemlerini etkilemektedir. Dolayısıyla
dijital haberleşme araçları dil öğretimi için de önemli bir materyaldir.
Dijital araçları kullanabilme becerileri ise dil öğretiminde kazandırılmalıdır.
Fakat öncelikle Türkçe öğretmenleri ve adaylarının dijital iletişim alışkanlıklarının
istenilen düzeyde olması gerekir. Araştırmada, Türkçe öğretmeni adaylarının bir
mobil cihaz uygulaması olan WhatsApp aracılığıyla sergiledikleri iletişim
alışkanlıklarının tespit edilmesi amaçlanmaktadır. Araştırma, tarama modeline
göre yürütülmüştür. Araştırmanın örneklemi, bir devlet üniversitesinin eğitim
fakültesinde öğrenim gören Türkçe öğretmeni adayları (n=102) arasından belirlenmiştir.
Adayların WhatsApp üzerinden gerçekleştirdikleri iletişim alışkanlarını tespit
etmek için alanyazındaki ilgili araştırmalardan hareketle araştırmacı
tarafından geliştirilmiş olan yarı yapılandırılmış görüşme formu kullanılmıştır. Hazırlanan form araştırmacı
tarafından örneklemdeki adaylara elden ulaştırılmış ve yüz yüze görüşme yapılarak
toplanmıştır. Elde edilen veriler üzerinde nitel analiz teknikleri kullanılarak
bulgular yorumlanmıştır. Araştırma sonucunda; adayların tamamının mesajlaşmak
için kolaylık, kitlesel kullanımı, işlevsellik gibi gerekçelerle WhatsApp’ı
kullandığı, çoğu adayın mesajlaşırken hitap ifadesi ile başladığı; iyi
dilek/temenni ifadesi ile bitirdiği gibi sonuçlara ulaşılmıştır.
METAFİZİK ÂLEMDEN CİNLERLE İRTİBATIN İMKANI/ İMKANSIZLIĞI: ETİMOLOJİK VE EPİSTEMOLOJİK BİR ANALİZ
Authors: Erdoğan İbrahim Halil
Published: October 2019

Metafizik varlıklara karşı
insanoğlunun ilgisi yaratılışından gelen karakteristik bir özelliktir. Gizemli
oluşlarından dolayı ilgi duyulan bu varlıkların başında cinleri zikretmek
mümkündür. Bulunduğumuz asırda bazı kimselerin cin ve ruh çağırma seansları,
cincilik, büyücülük gibi hakikati tam olarak bilinmeyen faaliyetler içinde
olduğu görülmektedir. Bu kimseler gaipten haber verdiği, çalınanların yerini
bildiği, kişinin gelecekteki yaşamı ile ilgili hayati önem taşıyan durumlardan
haberdar oldukları iddiayla, eskiden olduğu gibi toplumun dikkatini çekmeye
devam etmektedir. Bu faaliyetlerin bazen dini istismar boyutuna vararak, İslam’ın
tevhid tasavvuruna aykırı sapkın boyutlara ulaştığı bir realitedir. Bunların
büyük çoğunluğu, bu faaliyetlerini cinlerle iletişim kurarak yaptığını iddia
etmektedirler. Kelâmî eserlerde cinlere iman edilmesinin gerekli olduğunun yanı
sıra onların özellikleri de net olarak ortaya konulmuştur. Tarihin her
döneminde olduğu gibi günümüzde de cinlerle iletişim kurularak bir takım gaybî
haberlerin alındığı, onların istihdam edildiği gibi iddialar bu batıl inancın mütemadiyen
gündemde kalmasını sağlamıştır. Bu anlamda ruhani bir varlık olan cinlerin
maddeye etkilerinin olup olmadığı, insanlarla diyaloga geçip geçemeyecekleri ve
fiziki bir cisme teşekkül edip edemeyecekleri gibi konular ayrı ayrı incelenmeye
ve ortaya somut bilgilerin konulmasına muhtaçtır. Cin ve şeytanın varlığına
olan inancın, bir takım kötü niyetli kimseler tarafından istismar edilmesi
meselenin vuzuha kavuşturulması açısından büyük önem arz etmektedir.
Beyond Earthworm: Keeping the Promise
Authors: Johnson Caryl Erin
Published: October 2019

The founding of the Advanced National Seismic System (ANSS) vision was originally presented in U.S. Geological Survey Circular 1188 (U.S. Geological Survey [USGS], 1999), after many years of discussions and workshops, described in detail by Filson and Arabasz (2016). Much has been accomplished in the ensuing two decades. Disparate and sometimes divergent developments that had been previously explored at individual private and public universities were finally centralized with increased efficiency and coherency of effort. The stated mission of the ANSS is to “… provide accurate and timely data and information products for seismic events, including their effects on buildings and structures, employing modern monitoring methods and technologies.” In this article, an approach (xQuake) is proposed that does not interfere in any way with the mission of the National Earthquake Information Center and ANSS but instead restores much of the community focus and international collaboration that has been lost over the past two decades. xQuake uses an executable graph framework in a pipeline architecture; this framework can be seamlessly integrated into current ANSS quake monitoring systems. This new approach incorporates modern approaches to computer analytics, including multitopic Kafka exchange rings, cloud computing, a self-configuring phase associator, and machine learning. The xGraph system is free for noncommercial use, open source, hardware agnostic (Windows, Linux, Mac), with no requirement for commercial datastores.