bluuebunny/crossref_metadata_2025 huggingface dataset:
AREA OPTIMALIZATION WITH SYSTEMATIC LAYOUT PLANNING AND CLASS BASED STORAGE METHODS TO INCREASE STORAGE CAPACITY
Authors: Merjani Abdullah , Mulyadi Dede
Published: December 2023

PT Simatelex Manufactory Batam (SMB) is engaged in Coffee Maker and Pizza Maker. In the manufacture of these products, they are divided into several buildings in the Batamindo Industrial Park area, the products produced are made based on orders from customers. The products produced by the company are mostly marketed abroad (exports).

In the production of Coffee Maker which is located on Jl. Beringin Muka Kuning, Lot 003, Batamindo Industrial Park Area, Batam. Finished products are then stored in the warehouse area on the ground floor of the building (Ground) which has an area capacity of 60%, so that all finished goods cannot be stored, in addition to using an area of 60%, another cause of finished goods not being able to be stored is all mismatched placement. finished goods include Finished Goods Fresh from the production line and Finished Goods to Shipping, so that there are no finished goods to shipping sequences that are not in accordance with CO (Create Order) and there is a buildup of products in the finished goods area.

Therefore, the authors are interested in conducting research by anticipating these conditions so that it is necessary to optimize the storage of the finished goods. Improvements made in the form of changes to the flow of finished goods moving, re-layout the optimal warehouse stock level using the Systematic Layout Planning method, and making verbal control monitoring in the warehouse using the Class Based Storage method. From these improvements, the results obtained are an increase in area use by 60% to 80%, and also ensure that the area capacity can meet the company's needs.
PERANCANGAN MESIN ES BALOK BERSUMBER LISTRIK TENAGA MATAHARI DI DESA MUNTAI KABUPATEN BENGKALIS
Authors: Hasibuan Fardin , Wajhi Akramunnas Bastul , Widagdo Trijaya
Published: December 2023

fish is a food necessity as a source of protein for human life. Muntai Village in the Bantan District of Bengkalis Regency, Riau Province, is an area located on the Malacca Strait coast. Most of the village's population work as fishermen, both in saltwater and freshwater fishing. The primary production of fishermen is fish caught from the sea. The production of sea fish catches in the Bantan District in 2021 was 101 tons. Ice blocks are one of the components needed by the fishermen in Muntai Village. The distance from the village to the town, which takes around 1 to 1.5 hours, is a constraint in providing ice blocks for the fishermen in the village. The lack of electricity installation reaching the coastal area where the fishermen dock their boats is also one of the obstacles in providing ice blocks. The plan to create a solar-powered ice block machine is one of the alternative solutions to address the ice block supply issue for the fishermen in Muntai Village. The design of the ice block machine has a capacity of 3 tons per 24 hours with a power requirement of 13 kW and is sourced from solar panels with a specific number of solar cell modules. The investment cost required is Rp 833,051,670.00
ANALISA KETINGGIAN AIR PADA TANGKI BLOWDOWN MENGGUNAKAN METODE ZIEGLER – NICHOLS DI PT MITRA ENERGI BATAM
Authors: Irsyam Muhammad , Algusri Missyamsu , Mubarok Barep Sopan
Published: December 2023

The control system is the treatment that is carried out so that the system can run as it should. The aim of this control system is to achieve optimal, effective and efficient working conditions in a system. One example of a control system that is widely used today in industry is PID (Proportional, Integral and Derivative) control. Until now, some control system designers still have difficulty setting PID controller parameters. In this research, the author wants to know the differences between PID controllers using the Ziegler-Nichols tuning method. From the simulation results above using the Ziegler-Nichols method using the reaction curve method, the values Kp = 6.07, Ki = 1.37, and Kd = 6.67 were obtained with less than optimal signal response results where there was still an overshoot of 9.2% so that the Kp, Ki values were repeated. , and Kd using the second simulation method to obtain optimal signal response results with an overshoot of 0.49%, with values of Kp = 10.87, Ki = 1.42 and Kd = 6.83. And this research is to carry out a simulation to get a signal response using Matlab 2017b simulation on Simulink. Which can make it easier for us to create a PID controller block diagram.
PENGARUH U-TURN TERHADAP KINERJA LALU LINTAS PADA RUAS JALAN GAJAH MADA DEPAN SIMPANG SEKOLAH KEMILAU BANGSA KOTA BATAM
Authors: Kurniawan Harry , Anwar M. Khairi
Published: December 2023

Peningkatan volume kendaraan pada ruas jalan gajah mada depan simpang Sekolah Kemilau Bangsa Kota Batam terjadi di pagi hari jam 07.00 – 09.00 dan pada sore dari jam 16.00 – 18.00. Ruas jalan Gajah Mada merupakan jalan utama di tiban ke pusat kota Batam. Kawasan ini merupakan kawasan sekolah, perkantoran, pertokoan, pom bensin dan Restaurant. pengguna jalan baik yang searah maupun berlawanan arah. Kendaraan yang melewati ruas jalan ini khususnya di titik persimpangan sekolah kemilau bangsa dan kawasan SPBU tiban tiga ini mengalami kecepatan relatif rendah. Berdasarkan observasi penulis pada ruas jalan ini terlihat adanya perlambatan bagi kendaraan yang melintas dikarenakan kendaraan yang melakukan putar balik arah tidak dapat melakukan gerakan dengan lancar yang menimbulkan hambatan lalu lintas pada ruas jalan Gajah Mada khususnya di depan persimpangan sekolah kemilau bangsa tiban. Berdasarkan permasalahan tersebut, maka penelitian ini bertujuan untuk mengetahui kinerja pelayanan ruas jalan dan mengetahui waktu tempuh rata–rata kecepatan kendaraan pada saat melakukan U-Turn, panjang antrian dan pengaruh U-Turn pada kinerja ruas jalan Gajah Mada depan sekolah kemilau bangsa kota Batam. hasil penelitian arus volume kendaraan tertinggi pada hari jumat dengan skr/jam 4781,1 kearah barat dan kearah timur 4498,7 dengan kategori tingkat pelayanan jalan (D). Penelitian pada lokasi studi diperoleh hasil kelas hambatan samping masuk dalam katagori sangat tinggi, kecepatan arus bebas sebesar 50,61 km/jam dan kapasitas sebesar 6072 skr/jam. Hasil pengaruh fasilitas U-Turn menujukan perubahan pada lokasi studi. Pada lokasi U-Turn ke arah Barat diperoleh perubahan derajat kejenuhan dari 0,79 menjadi 0,81 dan keaarah Timur diperoleh 0,74 menjadi 0,71 dan waktu tempuh rata-rata kendaran melakukan gerak U-Turn dari Baran sebesar 45,63 dtk/jam dan ke arah Timur 42,30 dtk/jam dengan antrian kendaraan sepanjang 54 meter.
ALAT MONITORING PENGUKURAN TEKANAN DARAH PORTABLE DENGAN OUTPUT SUARA BERBASIS IoT
Authors: Wardhani Aditya , Anggraini Tisa , Yultrisna Yultrisna , Hendri Zulka , Nandika Reza
Published: December 2023

Telah dilakukan pembuatan alat monitoring pengukuran tekanan darah portable dengan output suara berbasis IoT yang didasarkan perawatan pasien dengan pendekatan berorientasi pasien. Dalam pendekatan ini pasien dilengkapi dengan pengetahuan dan informasi untuk lebih aktif dalam mendiagnosa penyakit dan melakukan tindakan pencegahan salah satunya pengukuran tekanan darah. Sasaran penelitian ini, yaitu (a) membuat sebuah prototipe sistem monitoring pengukuran tekanan darah portable dengan output suara berbasis IoT berbasis IoT, (b) mengukur kinerja sistem. Metode penelitian dimulai dari pembuatan prototipe, dan pengukuran kinerja sistem. Hasil pengukuran kinerja sistem, rata-rata erorr pada pembacaan nilai tekanan darah sebesar 2,49% untuk pembacaan tekanan darah sistolik dan 2,79% untuk pembacaan tekanan darah diastolic. Nilai erorr tersebut diperoleh dari 30 orang responden. Sistem dapat untuk pemantauan pembacaan data dari sensor MPX5050DP dengan penggunaan NodeMCU ESP8266 pada web server Thinkspeak melalui layar smartphone. Secara keseluruhan alat dapat berfungsi dengan baik.
Quantitative study of the use of psychotropic medications dispensed in a public pharmacy in the city of São Miguel do Iguaçu, Paraná
Authors: Santos Ariane Rodrigues dos , Colacite Jean , Souza Layse Fernanda Antônio de
Published: December 2023

Introduction: Access to medicines necessary for health recovery is a guaranteed right in most countries, but currently a third of the world's population does not have access to benefits that can be provided by essential pharmacological treatment. In Brazil, the population has easy access to free medicines, provided by the SUS (Unified Health System), for various diseases. Currently, the country is experiencing alarmingly growing numbers of cases of illnesses such as depression and anxiety, and the population is resorting to controlled medications in search of treatment or stability of the disease. Objective: Therefore, the present work proposes the main theme of pointing out the quantities of psychotropic medications dispensed annually to the population of São Miguel during five years, among them, one year presented was due to the Covid-19 pandemic. Materials and methods: this research was based on collecting data indicating the number of psychotropic medications dispensed by medication class, in the form of tablets, which were dispensed by the municipal basic pharmacy of São Miguel do Iguaçu, Paraná, from 2017 to 2021. Results and discussion: the municipality has high dispensing rates of controlled medications, although the population is less than 30 thousand inhabitants, mainly antidepressants, anticonvulsants, antipsychotics and benzodiazepines. Conclusion: the alarming numbers of dispensing in some years, in certain classes, were evident, raising awareness of the excessive consumption of controlled medications today, which has only been growing over the years, in all age groups.
Percepção dos acadêmicos de enfermagem referente ao transtorno de personalidade borderline
Authors: Lima Lucas Luvizutti , Neponuceno Náthally Silva , Osses Ingrid Solange Evans
Published: December 2023

O objetivo do trabalho consistiu em avaliar o conhecimento dos estudantes de enfermagem referente ao transtorno de personalidade borderline. Este estudo foi realizado através de uma pesquisa online disponibilizada pela plataforma “Google Forms”, aos estudantes de um Centro Universitário particular de Curitiba. Participaram 27 estudantes de enfermagem a partir do 7° período, durante o mês de outubro de 2023. Como resultados observamos que a maioria dos estudantes entrevistados relataram conhecer o transtorno de personalidade borderline e afirmaram ter tido ou estar tendo matérias destinadas à área da saúde mental. Sobre as causas, consequências e manifestações do transtorno, a maioria não soube responder pontualmente, além de não conseguir sondar ou detalhar mais precisamente suas respostas. Podemos concluir que o transtorno de personalidade borderline se faz presente, mas os conhecimentos dos estudantes sobre tal ainda não são devidamente satisfatórios. Portanto, se observa como necessidade aprofundar o tema em salas de aula, estágios acadêmicos, ampliando o conhecimento científico e promovendo o aperfeiçoamento e a capacitação dos profissionais na área.  Com isso os estudantes poderão se tornar aptos para acolher e lidar frente a condição social, patológica, ambiental e ao meio em que seu paciente está inserido.
Regularização fundiária no Piauí: Análise do Programa Regularizar na efetivação do direito à moradia
Authors: Macedo Kelvianny Daielly da Silva , Carvalho George Barbosa Jales de
Published: December 2023

Este estudo aborda a regularização fundiária no Piauí, enfocando a eficácia do Programa Regularizar na garantia do direito à moradia. A pesquisa tem como objetivo investigar os mecanismos jurídicos e operacionais adotados pelo programa, e é fundamentada em uma abordagem bibliográfica. A pesquisa se propõe a responder à questão central: quais mecanismos são empregados pelo Programa Regularizar do Estado do Piauí para a efetivação do direito fundamental à moradia? Para tanto, o trabalho é dividido em três capítulos que abordam desde marcos jurídicos e principiologicos até uma análise aprofundada do referido programa. A urgência do tema reside na constante violação de direitos fundamentais em assentamentos irregulares e na necessidade de reformulações legislativas e estratégicas que possam mitigar essa problemática. Os resultados visam fornecer subsídios para futuras iniciativas legislativas e políticas, dada a violação recorrente de direitos em assentamentos irregulares. Os resultados apontam que, apesar de avanços jurídicos, ainda existem desafios normativos e estruturais a serem superados.
KNOWLEDGE, ATTITUDES AND PRACTICES OF COMMUNITY PHARMACISTS ABOUT PROTON PUMP INHIBITORS
Authors: ALBAYRAK Aslınur , YILDIZ İrem
Published: December 2023

Objective: This study aimed to evaluate the knowledge, attitudes, and practices of community pharmacists about proton pump inhibitors (PPIs).
Material and Method: The study was a cross-sectional online survey study It was conducted with community pharmacists in Türkiye between 1 November 2022 and 15 April 2023. The survey questions were created by revising the previous study and consisted of 32 questions. Of these, 4 were about demographic information, 16 were about knowledge, 6 were about attitude, and 6 were about practices.
Result and Discussion: The vast majority of pharmacists who participated into the study (97.6%) knew that drugs such as pantoprazole, omeprazole, etc. were PPIs, and a majority of pharmacists (84.5%) knew that PPIs were inactive pro-drugs. 63.1% of the pharmacists answered correctly that omeprazole had the most individual variability. The vast majority (93.5%) of pharmacists believed that PPIs were overused in Türkiye. 86.3% of pharmacists believed that excessive consumption of PPIs resulted in increased costs and adverse drug reactions. 46 pharmacists (27.38%) declared that they have used PPIs in the last 1 year. Pantoprazole (15.5%) and lansoprazole (7.7%) were the most commonly used PPIs, respectively. According to our study, although pharmacists' knowledge, attitudes, and practices about PPIs were generally good, there were also some deficiencies in their knowledge. Therefore, pharmacists need to update themselves and be supported by interdisciplinary continuous educations.
Analisis Performansi Codec G.711 Dan G.729 Berbasis Issabel Menggunakan Metode MOS E-Model
Authors: Panca Aji , Rustam Rushendra
Published: December 2023

Komunikasi telah menjadi komponen penting dalam menjalankan bisnis, terutama dalam bisnis layanan terpadu (call center) di mana mungkin diperlukan untuk melakukan panggilan ke ribuan klien dalam satu hari karena kemajuan sistem telekomunikasi. Dalam kasus jaringan yang menangani transmisi VoIP, memastikan kualitas panggilan yang sesuai sangatlah penting. Penelitian ini bertujuan untuk mencari referensi codec audio terbaik untuk kebutuhan komunikasi suara sistem VoIP berbasis Issabel Server. Antara call codec G.729 dan G.711 dilakukan analisis mean opinion score dengan menggunakan teknik MOS E-MODEL (ITU-T G.107) menggunakan skenario call dengan durasi 30 detik, 60 detik, dan 120 detik dari ekstensi lokal ke jaringan PSTN. Codec G.729 dan G.711 memiliki nilai MOS 4.25061 pada waktu panggilan 30 detik. Codec G.711 bekerja lebih baik daripada codec G.729 dengan durasi panggilan 60 detik, dengan selisih persentase 0,153% (nilai MOS 4,24739) dibandingkan dengan nilai MOS codec G.729 sebesar 4,24087. Codec G.711 bekerja lebih baik daripada codec G.729 pada durasi panggilan 120 detik, dengan selisih persentase 0,018% (nilai MOS 4,24866) dibandingkan dengan nilai MOS codec G.729 sebesar 4,24787. Codec G.711 memiliki kualitas panggilan yang superior dibandingkan dengan codec G.729. Codec G.729 menggunakan sumber daya lebih efektif daripada codec G.711 meskipun kualitas panggilannya serupa dengan codec G.711.Kata kunci: MOS, G.711, G.729, Issabel, VoIP
Sistem Automasi Zero Touch Provisioning Routerboard Berbasis GraphQL API
Authors: Krisnayuda P Leonardus Daniel , Suni Eugenius Kau
Published: December 2023

Dalam sistem perangkat jaringan modern, idealnya sebuah perangkat jaringan memiliki manajemen sistem yang terpusat. Sistem manajemen terpusat yang baik memiliki kemampuan tidak sekedar monitoring, melainkan juga provisioning dan kegiatan administratif lain. Permasalahan yang dihadapi yakni perangkat jaringan routerboard tidak mampu melakukan provisioning secara mandiri dan otomatis. Untuk mengatasi masalah tersebut, perlu adanya sebuah sistem manajemen modern yang mampu melakukan provisioning secara otomatis, monitoring, dan juga administrasi konfigurasi secara massal. Dengan melakukan observasi dan studi literatur diketahui penggunaan routerboard dapat dimaksimalkan dengan fitur command line berupa HTTP request dan pemanfaatan arsitektur API. Penelitian ini mampu membuat sistem automasi zero touch provisioning routerboard, dengan menggunakan framework PHP Laravel dan GraphQL API. Hasil penelitian membuktikan bahwa sistem automasi mampu melakukan zero touch provisioning dengan memanfaatkan command line HTTP request untuk routerboard berkomunikasi ke server controller. Sedangkan untuk administrasi konfigurasi antara server controller ke routerboard, dilakukan melalui proses pemanggilan API. Pengujian yang dilakukan menunjukkan bahwa rata-rata durasi yang dibutuhkan dalam proses zero touch provisioning routerboard yakni 8.851ms.
Pengembangan Sistem Pendukung Keputusan Pemilihan Jurusan Menggunakan Metode Profile Matching di SMAN 4 Bangkalan
Authors: Faqih Fauziah Nur , Cahyani Laili
Published: December 2023

Penelitian ini bertujuan untuk mengembangkan sebuah Sistem Pendukung Keputusan (SPK) yang membantu siswa-siswi SMA Negeri 4 Bangkalan dalam memilih jurusan yang sesuai dengan minat dan potensi mereka. Dalam pengembangan SPK ini, peneliti menggunakan dua metode yang berbeda, yaitu metode Waterfall untuk pembangunan website dan metode Profile matching dalam pembangunan algoritma untuk menganalisis profil siswa. Metode Waterfall digunakan sebagai pendekatan linear dan sekuensial dalam pembangunan website, meliputi tahap analisis kebutuhan, desain, implementasi, dan pengujian. Website ini berfungsi sebagai platform utama dalam sistem pendukung keputusan. Sementara itu, metode Profile matching digunakan untuk mencocokkan profil siswa dengan kriteria tertentu guna memberikan rekomendasi jurusan yang sesuai. Data profil siswa yang mencakup minat bakat, prestasi akademik, dan aspek lainnya diintegrasikan dalam proses analisis untuk menentukan jurusan yang paling sesuai bagi masing-masing siswa. Hasil pengujian menunjukkan bahwa sistem yang dikembangkan memiliki akurasi 100% untuk semua skenario pengujian. Hal ini menandakan bahwa sistem memberikan rekomendasi jurusan dengan tingkat akurasi yang tinggi dan konsisten sesuai dengan data siswa. Uji coba pengguna juga menunjukkan respon positif dari pihak administrasi SMAN 4 Bangkalan terhadap sistem yang dibangun dengan hasil rata-rata 94,75%.
Implementasi Metode Convolutional Neural Network Untuk Deteksi Kematangan Buah Pisang Menggunakan Inception V3
Authors: Wulansari Novia Wahyu , Muslih Muslih
Published: December 2023

Pisang merupakan komoditi ekspor yang perlu diperhatikan kualitasnya. Salah satu cara mengetahui kualitasnya dapat dilihat dari tingkat kematangannya. Tingkat kematangan buah pisang tersebut dapat diklasifikasikan dan diidentifikasi oleh mata manusia secara langsung, tetapi dengan jumlah panen yang berlimpah akan memunculkan permasalahahan berhubungan dengan keputusan yang diambil secara cepat bahwa pisang tersebut disimpulkan mentah, matang atau busuk, maka diperlukan cara untuk mengklasifikasikan tingkat kematangan buah pisang dengan bantuan teknologi. Penelitian ini berfokus pada pengklasifikasian tingkat kematangan buah pisang dengan menggunakan arsitektur inception V3 yang merupakan pengembangan dari metode convolutional neural network. Model yang telah dikembangkan dapat menghasilkan akurasi 95% pada proses training dan pada proses evaluasi dengan menggunakan confusion matrix menghasilkan nilai precision sebesar 93%, nilai recall 94% dan nilai akurasi sebesar 94%.
Perbandingan Metode Peramalan ARIMA dan Single Exponential Smoothing pada Kasus Kejadian Demam Berdarah Dengue di Kota Semarang
Authors: Fahmi Amiq , Maurensa Giacinta , Hadi Heru Pramono , Hindarto Aris Nur , Wibowo Sasono , Sugiarto Edi
Published: December 2023

Demam berdarah dengue (DBD) merupakan masalah kesehatan yang signifikan di Indonesia, khususnya di Kota Semarang. Setiap tahunnya, terdapat tren peningkatan penderita demam berdarah. Jika pemangku kepentingan tidak melakukan tindakan dan kebijakan preventif, hal ini akan berdampak buruk pada kesehatan dan kesejahteraan masyarakat. Peramalan kasus di masa yang akan datang merupakan salah satu upaya pencegahan dan pengendalian penyakit DBD. Penelitian ini menggunakan teknik peramalan ARIMA dan Single Smoothing Exponential. Data time series yang digunakan adalah bulan Januari sampai dengan Desember 2022 berdasarkan kasus kejadian di tingkat kecamatan Kota Semarang. Hasil percobaan kedua metode tersebut kemudian dibandingkan untuk mencari hasil terbaik dalam memprediksi jumlah kasus DBD di Kota Semarang. Hasil penelitian menunjukkan bahwa metode ARIMA memberikan hasil terbaik, dengan nilai MSE dan MAE yang lebih kecil.
En sammanfattning av hur man hittar forskningsdata och var LiU-forskares forskningsdata finns
Authors: Hoshi Larsson Kaori
Published: December 2023

Denna rapport fokuserar på två huvudfrågor: Hur man hittar dataset och var forskare från Linköpings universitet (LiU) deponerar sina forskningsdata. Forskningsdata utgör grunden för vetenskapliga analyser och resultatvalidering. Dessutom förbättrar återanvändningen av forskningsdata forskningens effektivitet och påskyndar utvecklingen av vetenskaplig kunskap. Publicering av forskningsdata har blivit allt viktigare för forskare idag och att genom att publicera sina forskningsdata visa på sina vetenskapliga framsteg. Rapporten inleds med en översikt över forskningsdatalandskapet som betonar vikten av tillgänglighet och sökbarhet genom att följa FAIR-principerna (Findable, Accessible, Interoperable, Reusable) och konkreta rekommendationer för att hitta dataset ges. Sedan undersöks både generella och ämnesspecifika repositorier, och sökmotorer för dataset. Genom en metodologisk analys identifierades över 350 dataset från LiU-forskare, främst deponerade i Figshare, Zenodo och Dryad. Fördelningen av forskarnas institutionella affiliering har identifierats och anlyserats. Rapporten lyfter fram behovet av tydliga riktlinjer för LiU-forskare om datasetdeponering och betonar fortsatt arbete för att övervinna utmaningar i det fragmenterade forskningsdatalandskapet.
Facial mask for prevention of allergic rhinitis symptoms
Authors: Oğuz Oğuzhan , Manole Felicia , Bayar Muluk Nuray , Cingi Cemal
Published: December 2023

Objectives

We reviewed the role of facial masks in preventing allergic rhinitis (AR) symptoms.

Methods

The literature survey was performed in PubMed, EBSCO, UpToDate, and Proquest Central databases of Kırıkkale University and Google and Google Scholar databases.

Results

Aeroallergens are microscopic airborne particles that trigger AR symptoms. In sensitive people, the type 1 hypersensitivity reaction against these allergens occurs when these microparticles enter the nasal mucosa via inhalation. Pollens, molds, dust mites, and animal dander are only some of the allergens suspected of contributing to AR symptoms. The treatment guidelines for AR extensively encompass allergy avoidance and environmental management as the first-line treatment. It is recommended that those who experience seasonal symptoms try to avoid their triggers whenever possible. While medical masks filter out particles larger than 3 μm, FFP2 masks are effective against particles as small as 0.004 μm. Since both mask types are effective in filtering pollen larger than 5 μm in size, they can be used to prevent pollen exposure. The “antiviral protection” provided by medical and FFP2 masks to hospital employees is roughly equivalent. Thus, both should be effective against direct local (eye) or indirect inhaled (nose, bronchial) pollen exposure. For the masks to do their job, they need to fit correctly.

Conclusion

Face mask affects AR patients' quality of life and reduces AR symptoms' severity.
Is wing morphology across birds associated with life history and sociality?
Authors: Beauchamp Guy
Published: December 2023

Wings in birds vary tremendously in size and shape across species. Ecological needs are thought to shape variation across species in wing morphology over evolutionary times. For instance, demands for energetic efficiency in species that fly long distances have produced long and narrow wings with a high aspect ratio. Demand for maneuverability in cluttered habitats or to escape predators more easily have favored wings with large areas relative to body size producing a low wing loading. The association between ecological needs and wing morphology is complex, however, and could involve other ecological variables. Here, I draw attention to two ecological factors that have received little attention, namely, life history and sociality. Species at the slow end of the life history continuum emphasize adult survival over reproduction and are considered risk averse. I predicted that such species would benefit from low wing loading and low aspect ratio to increase maneuverability and the ability to escape predators. More solitary species cannot rely on others in their groups to decrease predation risk. I predicted that such species should also benefit from low wing loading and low aspect ratio. Using data from the literature on wing loading and aspect ratio in a large number of species, I examined these predictions in a phylogenetic framework including several potentially confounding ecological variables that have been previously linked to wing morphology such as habitat, lifestyle, and migration. As predicted, more solitary species tended to have low wing loading and low aspect ratio. Low wing loading was also more common in species at the slow end of the life history continuum, but aspect ratio was higher than predicted. Overall, the results support the idea that life history and sociality can predict variation across species in wing morphology and highlight the effect of predation risk on the evolution of wing morphology in birds.
Technology engagement is associated with higher perceived physical well-being in stroke patients prescribed smartwatches for atrial fibrillation detection
Authors: Mensah Otabil Edith , Dai Qiying , Anzenberg Paula , Filippaios Andreas , Ding Eric , Mehawej Jordy , Mathew Joanne E. , Lessard Darleen , Wang Ziyue , Noorishirazi Kamran , Hamel Alexander , Paul Tenes , DiMezza Danielle , Han Dong , Mohagheghian Fahimeh , Soni Apurv , Lin Honghuang , Barton Bruce , Saczynski Jane , Chon Ki H. , Tran Khanh-Van , McManus David D.
Published: December 2023

Background

Increasing ownership of smartphones among Americans provides an opportunity to use these technologies to manage medical conditions. We examine the influence of baseline smartwatch ownership on changes in self-reported anxiety, patient engagement, and health-related quality of life when prescribed smartwatch for AF detection.

Method

We performed a post-hoc secondary analysis of the Pulsewatch study (NCT03761394), a clinical trial in which 120 participants were randomized to receive a smartwatch-smartphone app dyad and ECG patch monitor compared to an ECG patch monitor alone to establish the accuracy of the smartwatch-smartphone app dyad for detection of AF. At baseline, 14 days, and 44 days, participants completed the Generalized Anxiety Disorder-7 survey, the Health Survey SF-12, and the Consumer Health Activation Index. Mixed-effects linear regression models using repeated measures with anxiety, patient activation, physical and mental health status as outcomes were used to examine their association with smartwatch ownership at baseline.

Results

Ninety-six participants, primarily White with high income and tertiary education, were randomized to receive a study smartwatch-smartphone dyad. Twenty-four (25%) participants previously owned a smartwatch. Compared to those who did not previously own a smartwatch, smartwatch owners reported significant greater increase in their self-reported physical health (β = 5.07, P < 0.05), no differences in anxiety (β = 0.92, P = 0.33), mental health (β = −2.42, P = 0.16), or patient activation (β = 1.86, P = 0.54).

Conclusions

Participants who own a smartwatch at baseline reported a greater positive change in self-reported physical health, but not in anxiety, patient activation, or self-reported mental health over the study period.
Expression of neuroendocrine markers predicts increased survival in triple-negative breast cancer patients
Authors: Xia Chuan , Shen Songjie , Pang Junyi , Chen Longyun , Yan Jie , Liang Zhiyong , Ren Xinyu
Published: December 2023

Background

The significance of neuroendocrine (NE) markers in triple-negative breast cancer (TNBC) patients has not been investigated. This study aims to clarify the incidence and prognostic significance of NE marker expression in TNBC, determine its association with other clinicopathological parameters, and further explore the pathological features and potential treatment options for TNBC patients expressing NE markers.

Methods

Clinicopathological data were collected from 396 TNBC patients undergoing radical breast cancer surgery at Peking Union Medical College Hospital from January 2002 to December 2014, with a final follow-up in July 2019. Immunohistochemistry (IHC) staining was performed for NE markers including chromogranin A (CgA) and synaptophysin (Syn). For TNBC patients with positive NE marker expression, IHC staining was then performed for alpha-thalassemia/mental retardation X-linked (ATRX), O(6)-methylguanine-methyltransferase (MGMT), somatostatin receptor 2 (SSTR2), and programmed death receptor-ligand 1 (PD-L1). The chi-square or Fisher exact test was used to evaluate the correlations between NE marker expression and other parameters. Survival curves were plotted using the Kaplan-Meier (K-M) method to assess the prognostic significance of NE markers in TNBC.

Results

NE marker-positive staining was observed in 7.6% (30/396) of all TNBC cases. Only 0.5% (2/396) cases had ≥ 90% neoplastic cells expressing NE markers. Positive NE marker expression was associated with negative basal-like marker expression. K-M survival analysis showed that the NE marker-positive TNBC patients had higher disease-free survival (DFS) rates than the NE marker-negative patients at the same stage. Among the 30 NE marker-positive TNBC cases, 13.3% and 26.7% showed negative IHC staining for ATRX and MGMT, respectively, while 13.3% had a 3+ score for SSTR2 IHC staining. For PD-L1 IHC staining, 13.3% of the 30 TNBC cases were higher than 10 scores in Combined Positive Score (CPS), and 10.0% were higher than 10% in Tumor Cell Proportion Score (TPS).

Conclusion

There was a small proportion of TNBC patients expressing NE markers. TNBC patients with positive NE marker expression had a better prognosis than the negative group at the same stage. TNBC cases with positive NE marker expression may potentially benefit from immunotherapy or somatostatin analogue treatment.
Effect of beinaglutide combined with metformin versus aspart 30 with metformin on metabolic profiles and antidrug antibodies in patients with type 2 diabetes: a randomized clinical trial
Authors: Han Chen-Yu , Lu Jia-Ping , Ye Xiao-Mei , Jin Hai-Ying , Xu Wei-Wei , Wang Ping , Zhang Min
Published: December 2023

Objective

This prospective study aimed to evaluate the effect of beinaglutide combined with metformin versus aspart 30 with metformin on metabolic profiles and antidrug antibodies (ADAs) in patients with type 2 diabetes (T2D).

Methods

A total of 134 eligible participants were randomly assigned to the test group and the control group. Patients in the test group were treated with beinaglutide and metformin, whereas patients in the control group were randomly treated with aspart 30 and metformin, with a follow-up period of 6 months. The metabolic profiles and ADAs over 6 months were evaluated.

Results

After 6 months, 101 (75.37%) patients completed the study. Compared with the control group, the beinaglutide group had significant reductions in 2-h postprandial blood glucose (2hBG) and low blood glucose index (LBGI). Glycated hemoglobin (HbA1c) decreased in both groups relative to baseline. In the test group, one had treatment-emergent beinaglutide ADAs. Significant reductions in triglycerides (TG), non-fasting TG, weight, waist circumference (WC), and body mass index (BMI) were observed. The values of insulin sensitivity index (HOMA-IR) were decreased to a statistically higher degree with beinaglutide treatment.

Conclusion

Beinaglutide reduces metabolic dysfunction, LBGI, and weight in patients of T2D with a low risk of ADAs. Beinaglutide may offer the potential for a disease-modifying intervention in cardiovascular disease (CVD).

Clinical trial registration

www.chictr.org.cn, identifier ChiCTR2200061003.
Analysis of sub-synchronous oscillation characteristics of PMSGs based on transient energy
Authors: Yan Gangui , Wang Yupeng , Yang Cheng , Yue Lin
Published: December 2023

Faced with the problem of sub-synchronous oscillation (SSO) caused by the interaction between permanent magnetic synchronous generator (PMSG)-based wind farms and weak AC grids, we construct a transient energy function model that follows the structure of a PMSG. The transient energy composition of a PMSG is analyzed, and the dissipation energy expression that can intuitively reflect the development trend of SSO is derived, reflecting the damping level of a grid-connected wind power system. Furthermore, in response to the problem of mutual coupling between the control links of the PMSG during the SSO process, which hinders oscillation characteristic assessment, a method based on oscillation energy is proposed to analyze the oscillation characteristics. Considering the dynamic changes in the output of the phase-locked loop during sub-synchronous oscillation, the transient energy dominated by various control links is derived, and the effects of the phase-locked loop, current inner loop, and voltage outer loop on transient energy and oscillation characteristics are analyzed. The simulation verifies the effectiveness of the analysis of the transient energy model.
Identification of key genes modules linking diabetic retinopathy and circadian rhythm
Authors: Ling Feng , Zhang Caijie , Zhao Xin , Xin Xiangyang , Zhao Shaozhen
Published: December 2023

Background

Diabetic retinopathy (DR) is a leading cause of vision loss worldwide. Recent studies highlighted the crucial impact of circadian rhythms (CR) on normal retinopathy in response to the external light cues. However, the role of circadian rhythms in DR pathogenesis and potential investigational drugs remains unclear.

Methods

To investigate the weather CR affects DR, differential expression analysis was employed to identify differentially expressed genes (DEGs) from the GEO database (GSE160306). Functional enrichment analysis was conducted to identify relevant signaling pathways. LASSO regression was utilized to screen pivotal genes. Weighted gene co-expression network anlaysis (WGCNA) was applied to identify different modules. Additionally, we use the Comparative Toxicogenomics Database (CTD) database to search key genes related to drugs or molecular compounds. The diabetic mouse model received three consecutive intraperitoneal injections of streptozotocin (STZ) during 3 successive days.

Results

We initially identified six key genes associated with circadian rhythm in DR, including COL6A3, IGFBP2, IGHG4, KLHDC7A, RPL26P30, and MYL6P4. Compared to normal tissue, the expression levels of COL6A3 and IGFB2 were significantly increased in DR model. Furthermore, we identified several signaling pathways, including death domain binding, insulin-like growth factor I binding, and proteasome binding. We also observed that COL6A3 was positively correlated with macrophages (cor=0.628296895, p=9.96E-08) and Th17 cells (cor=0.665120835, p=9.14E-09), while IGFBP2 showed a negatively correlated with Tgd (cor=-0.459953045, p=0.000247284) and Th2 cells (cor=-0.442269719, p=0.000452875). Finally, we identified four drugs associated with key genes: Resveratrol, Vitamin E, Streptozocin, and Sulindac.

Conclusion

Our findings revealed several key genes related to circadian rhythms and several relevant drugs in DR, providing a novel insight into the mechanism of DR and potential implications for future DR treatment. This study contributes to a better understanding of CR in DR and its implications for future therapeutic interventions.
Combining CD4 count, CD8 count and CD4/CD8 ratio to predict risk of mortality among HIV-positive adults after therapy: a group-based multi-trajectory analysis
Authors: Ma Jing , Wang Guoyong , Zhu Xiaoyan , Li Ling , Wang Lin , Hao Lianzheng , Gao Lijie , Ma Wei , Zhang Na
Published: December 2023

Introduction

Previous studies have indicated different immunological recovery trajectories based on CD4 count or CD4/CD8 ratio. However, these immune indicators are interconnected, and relying solely on one indicator may lead to inaccurate estimates. Therefore, it is essential to develop a comprehensive trajectory model that integrates CD4 count, CD8 count and CD4/CD8 ratio.

Methods

We utilized a group-based multi-trajectory model to characterize the latent cluster of recovery based on measurements of CD4 count, CD8 count and CD4/CD8 ratio over a period of up to 96 months following ART initiation. Subsequently, we investigated the characteristics associated with trajectory groups, especially sex and age. Cox model and Kaplan-Meier survival curve were employed to assess differences in all-cause, AIDS-related and non-AIDS related mortality between trajectory groups.

Results

A total of 14,718 eligible individuals were followed for a median of 55 months. Longitudinal model identified four subgroups: group 1 (32.5%, low CD4 and CD4/CD8 inversion), group 2 (25.9%, high CD8 and CD4/CD8 inversion), group 3 (27.2%, slow recovery of CD4 and CD4/CD8 inversion) and group 4 (14.4%, rapid increase of CD4 and normal CD4/CD8). Immune recovery was slower in male than in female, and in elders than in youngers. Compared to group 2, group 1 (adjusted hazard ratio [aHR]=3.28; 95% CI 2.33-4.60) and group 3 (aHR=1.56; 95% CI 1.09-2.24) had increased risk of all-cause mortality after adjusting for other factors. Besides, group 1 (aHR=2.17) and group 3 (aHR=1.58) had higher risk of non-AIDS related mortality, and group 1 (aHR=5.92) had significantly increased risk of AIDS related mortality.

Conclusion

Longitudinal trajectory analysis of multiple immune indicators can be employed to guide targeted interventions among vulnerable populations in clinical practice.
Efficacy and safety of camrelizumab combined with albumin-bound paclitaxel as third- or later-line regimen in patients with advanced non-small cell lung cancer
Authors: Zhu Jianfeng , Yu Yanyan , Mei Jiaqi , Chen Shiyao , Li Jiufei , Jiang Sicong
Published: December 2023

Background

The clinical efficacy and safety of camrelizumab as a third- or later-line regimen in patients with advanced non-small cell lung cancer (NSCLC) have not been determined in large clinical trials.

Objective

This study aimed to evaluate the clinical efficacy and safety of camrelizumab in combination with albumin-bound paclitaxel as a third- or later-line treatment for patients with advanced NSCLC.

Methods

A total of 257 patients with advanced NSCLC who were histopathologically confirmed and failed in clinical second-line therapy regimens at Jiangxi Province Cancer hospital from January 2018 to December 2021 were retrospectively selected. Patients with advanced NSCLC were divided into the single treatment group (STG) of camrelizumab, and the combined treatment group (CTG) of camrelizumab in combination with albumin-bound paclitaxel according to the treatment regimen. The primary outcomes of interest were clinical efficacy[objective response rate (ORR) and disease control rate (DCR)], progression-free survival (PFS), and overall survival (OS). Survival data were analyzed using the Kaplan-Meier method, and the log-rank test was performed. Additionally, Cox proportional hazard regression was used to analyze the correlation of prognosis and baseline characteristics between subgroups, to identify the potential independent risk factors for PFS and OS. Furthermore, the occurrence of side effects was assessed according to the Common Terminology Criteria for Adverse Events (CTCAE 4.03).

Results

Of the 257 patients with advanced NSCLC included in the research, 135 patients received camrelizumab, and 122 patients received camrelizumab plus albumin-bound paclitaxel. The ORR of CTG and STG was 59.84% and 50.38%, and the DCR was 77.05% and 65.93%, respectively. The median PFS in CTG was higher than that in the STG (5.27 vs. 3.57 months, P = 0.0074), and the median OS was longer (7.09 vs. 6.47 months, P < 0.01). The lines of treatment, metastases, and PD-L1 expression levels were independent risk factors for the mPFS and mOS of patients with advanced NSCLC. The occurrence of adverse events was similar between camrelizumab and camrelizumab plus albumin-bound paclitaxel groups.

Conclusion

Camrelizumab combined with albumin-bound paclitaxel as the third- or later-line regimen greatly prolonged PFS and OS of advanced NSCLC patients. A prospective clinical trial is warranted.
Mouse models of diffuse large B cell lymphoma
Authors: Tabatabai Areya , Arora Aastha , Höfmann Svenja , Jauch Maximilian , von Tresckow Bastian , Hansen Julia , Flümann Ruth , Jachimowicz Ron D. , Klein Sebastian , Reinhardt Hans Christian , Knittel Gero
Published: December 2023

Diffuse large B cell lymphoma (DLBCL) is a genetically highly heterogeneous disease. Yet, to date, the vast majority of patients receive standardized frontline chemo-immune-therapy consisting of an anthracycline backbone. Using these regimens, approximately 65% of patients can be cured, whereas the remaining 35% of patients will face relapsed or refractory disease, which, even in the era of CAR-T cells, is difficult to treat. To systematically tackle this high medical need, it is important to design, generate and deploy suitable in vivo model systems that capture disease biology, heterogeneity and drug response. Recently published, large comprehensive genomic characterization studies, which defined molecular sub-groups of DLBCL, provide an ideal framework for the generation of autochthonous mouse models, as well as an ideal benchmark for cell line-derived or patient-derived mouse models of DLBCL. Here we discuss the current state of the art in the field of mouse modelling of human DLBCL, with a particular focus on disease biology and genetically defined molecular vulnerabilities, as well as potential targeting strategies.
The value of age IgG and IL6 in estimating time of viral clearance in asymptomatic or mild patients with COVID-19
Authors: Cao Xi , Xie Yong-Li , Zhou Chun-lei , Mu Hong
Published: December 2023

Background

The aim of this study was to investigate the relationship between Age, immunoglobin G (IgG), immunoglobin M (IgM), procalcitonin (PCT), and interleukin-6 (IL6), and the time to clear viral nucleic acids in asymptomatic and mild coronavirus disease 2019 (COVID-19) patients, as well as evaluated the predictive value of these biochemical indicators.

Methods

We performed a retrospective analysis on 1,570 individuals who were admitted to Tianjin First Central Hospital and diagnosed with asymptomatic or mild cases. Laboratory data were collected, including age, gender, levels of IgG, IgM, PCT and IL6, as well as results of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) nucleic acid test. These data were statistically analyzed using SPSS software, version 24.0.

Results

The results indicated that among mild patients, Age, IgG, and the time to clear viral nucleic acids were higher than asymptomatic patients (p < 0.05). And the time to clear viral nucleic acids was significantly correlated with Age, IgG, IgM, PCT, and IL6 (p < 0.05), IgG (r = −0.445, p < 0.001) showed moderate correlations. Using logistic regression analysis, we identified older age, high IL6 levels, and low IgG levels were risk factors for nucleic acid clearance exceeding 14 days (p < 0.05). When combining these three indicators to predict the probability of nucleic acid clearance exceeding 14 days in the 1,570 patients, the AUROC was found to be 0.727.

Conclusion

Age, IgG, and IL6 could potentially serve as useful predictors for nucleic acid clearance exceeding 14 days in asymptomatic and mild COVID-19 patients.
Global characteristics and trends in research on Candida auris
Authors: Wang Qihui , Cheng Shitong , Wang Yinling , Li Fushun , Chen Jingjing , Du Wei , Kang Hui , Wang Zhongqing
Published: December 2023

Introduction

Candida auris, a fungal pathogen first reported in 2009, has shown strong resistance to azole antifungal drugs and has caused severe nosocomial outbreaks. It can also form biofilms, which can colonize patients’ skin and transmit to others. Despite numerous reports of C. auris isolation in various countries, many studies have reported contradictory results.

Method

A bibliometric analysis was conducted using VOSviewer to summarize research trends and provide guidance for future research on controlling C. auris infection. The analysis revealed that the United States and the US CDC were the most influential countries and research institutions, respectively. For the researchers, Jacques F. Meis published the highest amount of related articles, and Anastasia P. Litvintseva’s articles with the highest average citation rate. The most cited publications focused on clade classification, accurate identification technologies, nosocomial outbreaks, drug resistance, and biofilm formation. Keyword co-occurrence analysis revealed that the top five highest frequencies were for ‘drug resistance,’ ‘antifungal susceptibility test,’ ‘infection,’ ‘Candida auris,’ and ‘identification.’ The high-frequency keywords clustered into four groups: rapid and precise identification, drug resistance research, pathogenicity, and nosocomial transmission epidemiology studies. These clusters represent different study fields and current research hotspots of C. auris.

Conclusion

The bibliometric analysis identified the most influential country, research institution, and researcher, indicating current research trends and hotspots for controlling C. auris.
Spatial adjustment of bioenergetics, a possible determinant of contractile adaptation and development of contractile failure
Authors: Szibor Marten , Mühlon Marie , Doenst Torsten , Pohjoismäki Jaakko L. O.
Published: December 2023

Cardiomyocytes depend on mitochondrial oxidative phosphorylation (OXPHOS) for energy metabolism, which is facilitated by the mitochondrial electron transfer system (ETS). In a series of thermogenic redox reactions, electrons are shuttled through the ETS to oxygen as the final electron acceptor. This electron transfer is coupled to proton translocation across the inner mitochondrial membrane, which itself is the main driving force for ATP production. Oxygen availability is thus a prerequisite for ATP production and consequently contractility. Notably, cardiomyocytes are exceptionally large cells and densely packed with contractile structures, which constrains intracellular oxygen distribution. Moreover, oxygen must pass through layers of actively respiring mitochondria to reach the ones located in the innermost contractile compartment. Indeed, uneven oxygen distribution was observed in cardiomyocytes, suggesting that local ATP supply may also vary according to oxygen availability. Here, we discuss how spatial adjustment of bioenergetics to intracellular oxygen fluctuations may underlie cardiac contractile adaptation and how this adaptation may pose a risk for the development of contractile failure.