bluuebunny/crossref_metadata_2025 huggingface dataset:
Thermo-oxidative Oligomerization of Aromatic Diamine
Authors: Zaitsev B. А. , Kleptsova L. G. , Shvabskaya I. D. , Bursian А.E.
Published: February 2022

Molecular spectroscopy (electronic, FT-IR, NMR), methods of thermal and elemental analysis were used for the first time to describe the process of thermo-oxidative oligomerization of 1,3-bis-(4-aminophenoxy)benzene. Introduction of this monomer into linear and network copolymers makes it possible to improve processability, mechanical strength and heat resistance of materials. The structures of copolymers obtained by thermo-oxidation of the diamine in various thermal regimes were studied. It was demonstrated that during prolonged heating of this diamine in air in the temperature range from 220 to 320°C, oligomeric aromatic diamines were formed; these products contained fragments of benzenoid and quinoid types.
Penguatan Kapasitas UMKM di Tingkat Kalurahan: Pemberdayaan Masyarakat dengan Pengolahan Daun Kelor untuk Peningkatan Ekonomi Daerah
Authors: Insani Dian Aurelia Pramudita
Published: February 2022

Permasalahan yang melatar belakangi penelitian ini adalah berkaitan dengan minimnya pemanfaatan potensi alam berupa daun kelor di Kalurahan Pilangrejo, Kabupaten Gunungkidul, Daerah Istimewa Yogyakarta. Berangkat dari kondisi tersebut Unit Kegiatan Mahasiswa (UKM) Kelompok Penelitian Mahasiswa (KPM) Universitas Muhammadiyah Yogyakarta (UMY) mengagas sebuah program Argoindustri Kelor Terintegrasi Berbasis Supply Chain Management (SCM). Kegiatan tersebut merupakan aktualisasi dari Program Holistik Pembinaan dan Pemberdayaan Desa (PHP2D) yang diselenggarakan oleh Direktorat Jenderal Pendidikan Tinggi (Ditjen Dikti), Kementerian Pendidikan dan Kebudayaan (Kemendikbud). Tujuan dari penelitian ini adalah mengkaji terkait proses pemberdayaan melalui program Agroindustri Kelor Terintegrasi Berbasis SCM yang dilakukan oleh UKM-KPM UMY terhadap UMKM di Kalurahan Pilangrejo dengan menggunakan konsep Green Economy. Selanjutnya, metode yang digunakan dalam penelitian ini adalah kualitatif dengan pendekatan studi kasus. Berkaitan dengan analisis data dalam penelitian ini menggunakan teknik interaktif model yang meliputi pengumpulan data, reduksi data, peyajian data, dan penarikan kesimpulan. Hasil dari penelitian ini menunjukkan bahwa pemberdayaan masyarakat melalui UMKM Agroindustri Handayani Kelor menciptakan suatu investasi serta peluang kerja dalam bidang ekonomi daerah yang berdampak pada meningkatnya Gross Domestic Product (GDP) melalui pemasaran produk hasil olahan daun kelor.
Sosialisasi Strategi Pemasaran pada Pemilik UMKM Desa Kaliabu Caruban Kabupaten Madiun
Authors: Sulistyowati Nur Wahyuning , Luchindawati Diza Satrina , Munawaroh Titin Ervita
Published: February 2022

Promosi dari mulut ke mulut, papan nama, label merupakan strategi pemesaran yang sudah dilakukan pemilik UMKM Desa Kaliabu Caruban Kabupaten Madiun. Namun dengan berkembangnya teknologi, promosi dapat dilakukan melalui media sosial. Hal ini yang melatarbelakangi tim pengabdian kepada masyarakat untuk melaksanakan Sosialisasi Strategi Pemasaran Pada Pemilik UMKM Desa Kaliabu Caruban Kabupaten Madiun dengan tujuan memperluas pangsa pasar ke manca negara untuk mempromosikan produk UMKM Desa Kaliabu baik promosi secara offline maupun online yang dapat dilakukan melalui media sosial antara lain meliputi twitter, Instagram, facebook, whatsapp, dan lain sebagainya. Metode pelaksanaan pengabdian masyarakat ini dilaksanakan dengan memberikan Sosialisasi Strategi Pemasaran yang dihadiri oleh bapak dan ibu pemilik UMKM desa Kaliabu Caruban Kabupaten Madiun berjumlah 19 peserta. Setelah selesai penjelasan materi dilanjutkan dengan tanya jawab dan sharing. Hasil pengabdian menunjukkan bahwa pemilik UMKM Desa Kaliabu Caruban Kabupaten Madiun sudah melakukan promosi dengan offline. Pentingnya daripada program pengabdian ini yaitu pemilik UMKM telah mengembangkan promosi baik dengan offline maupun digital online, saling bekerjasama antar pemilik UMKM dengan produk yang sama untuk memenuhi kebutuhan permintaan ekspor produk UMKM, menjadi sentra brem Desa Kaliabu Caruban Kabupaten Madiun.
Pendampingan UKM Tahu Kampung Trunan Magelang Melalui Strategi Pemasaran POSM dan WOM
Authors: Achsa Andhatu , Verawati Dian Marlina , Novitaningtyas Ivo
Published: February 2022

Program pengabdian ini dilatarbelakangi oleh permasalahan mitra yaitu menurunnya volume penjualan. Tujuan dari program ini adalah meningkatkan pemahaman dan kemampuan mitra terhadap strategi pemasaran POSM dan WOM. Program dilaksanakan menggunakan metode sosialisasi dan pelatihan kepada 20 UKM tahu sebagai sasaran program. Hasil pelaksanaan program menunjukkan bahwa terdapat peningkatan pemahaman mitra terhadap strategi POSM dan WOM dalam rangka meningkatkan minat beli konsumen, serta peningkatan keterampilan mitra dalam membuat material pendukung POSM untuk menarik minat beli konsumen. Melalui pelaksanaan program ini diharapkan agar minat beli konsumen terhadap produk UKM tahu meningkat sehingga berdampak pada peningkatan volume penjualan dan menjadi solusi bagi permasalahan mitra.
Pelatihan Diversifikasi Produk nntuk Peningkatan Produktivitas Pelaku UKM Tahu
Authors: Islami Fitrah Sari , Destiningsih Rian , Achsa Andhatu
Published: February 2022

Latar belakang kegiatan pengabdian  adalah menurunnya kesejahteraan mitra dari sisi penjualan. Hal ini disebabkan oleh lemahnya pemasaran produk dan kurangnya inovasi dalam produk usaha. Pengabdian dilakukan dengan tujuan untuk meningkatkan kemampuan mitra dalam melakukan diversifikasi, inovasi dan pemasaran produk untuk peningkatan produktivitas mitra. Mitra dalam kegiatan pengabdian ini adalah para pelaku UKM Tahu yang terdiri dari 20 pengusahan UKM Tahu. Pengabdian dilaksanakan dengan menggunakan metode ceramah, tutorial pembuatan diversifikasi produk dan kegiatan diskusi. Hasil kegiatan pengabdian menunjukkan peningkatan pemahaman pelaku usaha dalam berbagai variasi produk, peningkatan kemampuan pelaku usaha dalam membuat ragam variasi produk salah satunya “tahu walik” dan pengetahuan mengenai strategi dalam pemasaran produk saat ini. Dari pelaksanaan kegiatan ini, para pelaku UKM Tahu tertarik untuk membuat tahu walik. Melalui pelaksanaan kegiatan pengabdian ini, diharapkan dapat meningkatkan kesejahteraan usaha para pelaku UKM Tahu.
Pengaruh Media Video Edukasi terhadap Peningkatan Pengetahuan Anemia pada Remaja Putri
Authors: Fadhilah Tri Marta , Qinthara Ferar Zidni , Pramudiya Faiz , Nurrohmah Firdha Safinah , Nurlaelani Haliza Putri , Maylina Nita , Alfiraizy Nuke
Published: February 2022

Remaja yaitu penduduk yang masih tergolong dalam rentan usia 10-19 tahun. Anemia adalah suatu keadaan dimana kadar hemoglobin (Hb) dalam darah kurang dari normal. Keadaan social ekonomi rendah seperti Pendidikan orang tua dan penghasilan yang rendahserta Kesehatan lingkungan yang buruk merupakan factor yang mempengaruhi tingginya prevalensi anemia gizi besi di Inodesia. Pemberian edukasi pendidikan gizi ini dilakukan secara online pada bulan Desember 2020. Sasaran kegiatan edukasi pendidikan gizi ini adalah Remaja Putri dengan membagikan media berupa video edukasi yang berisi beberapa cuplikan dengan instrumen powtoon. Metode yang digunakan dalam penyuluhan ini yaitu menggunakan metode video terkait anemia dengan instrumen powtoon dan kuesioner. Kegiatan pemberian edukasi gizi ini diawali dengan penyebaran flyer yang mencantumkan link kuesioner pre-test (Sebelum menonton video) dan link kuesioner post-test (Setelah menonton video). Pendidikan edukasi gizi ini bertujuan untuk meningkatkan pengetahuan remaja putri terkait Anemia dan pentingnya mencegah Anemia. Hasil data umur responden paling banyak pada kelompok Remaja Akhir (Usia 18 - 21 tahun) yaitu 47 orang (61%). Sedangkan data asal provinsi lebih banyak pada Jawa barat yaitu 48 orang (62%). Hasil dari perhitungan statistika, data pengetahuan Anemia terhadap remaja putri menunjukan peningkatan yang signifikan dengan nilai p-value <0,05. Kesimpulan kegiatan ini adalah terdapat pengaruh peningkatan antara sebelum dan setelah diberikan pendidikan gizi melalui video pengetahuan anemia pada remaja putri.
REALITAS SOSIAL DALAM WAYANG DURANGPO KARYA SUJIWO TEJO PADA HARIAN JAWA POS
Authors: Shofiani Arisni Kholifatu
Published: February 2022

Wayang adalah sebuah wiracarita yang pada intinya mengisahkan kepahlawanan para tokoh yang berwatak baik menghadapi dan menumpas tokoh yang berwatak jahat. Wayang yang telah melewati berbagai peristiwa sejarah, dari generasi, menunjukkan betapa budaya pewayangan telah melekat dan menjadi bagian hidup Bangsa Indonesia, khususnya Jawa. Usia yang demekian panjang dan kenyataan bahwa hinga dewasa ini masih banyak orang yang menggemarinya menunjukkan betapa tinggi bilai dan berartinya wayang bagi kehiduipan masyarakat. Sumber data artikel ini adalah Wayang Durangpo karya Sujowo Tejo yang terbit di Jawa Pos pada setiap hari minggu. Landasan teori yang digunakan dalam penelitian ini kajian sosiologi sastra dengan fokus realitas sosial. Metode penelitian menggunakan pendekatan penelitian kualitatif lebih menitik beratkan pada kaitan karya sastra itu sendiri, yaitu aspek sosial. Teknik pengumpulan data ini mengguinakan teknik pustaka atau dokumnentasi yang memanfaatkan sumber-sumber data yaitu Wayang Durangpo dalam rubrik  harian koran Jawa Pos. Peneliti menggunakan teknik analisis isi dengan menganalisis dokumen untuk mengetahui isi dan maknanya. Penelitian ini banyak mengungkap  realitas sosial yang tejadi pada masyarakat, yaitu realitas tentang pendidikan, deskriminsai, kebudayaan,kepribadian seseorang, sifat seseorang,  dan kepemimpinan
KEADILAN SOSIAL BAGI SELURUH RAKYAT INDONESIA PADA CERITA RAKYAT DARI DESA-DESA DI SIDOARJO
Authors: Susilo Joko , Junaedi Muhammad , Tirtoni Feri , Sarika Septi Budi , Astuti Cindy Cahyaning , Fediyanto Niko
Published: February 2022

Kajian ini merupakan penerapan dan praktik bagi dosen dan mahasiswa untuk menggali kearifan lokan dengan turun langsung ke 3 desa berkarakter budaya yang ada di Sidoarjo.  Desa-desa di Sidoarjo mempunyai cerita rakyat atau kisah asal-usul yang diceritakan secara lisan secara turun-temurun ke tiap generasi. Cerita rakyat tersebut memiliki konsep kearifan yang layak dikaji sebagai solusi alternatif untuk praktik merdeka belajar. Penelitian ini bertujuan untuk mengkaji kembali cerita rakyat dari desa-desa di Sidoarjo selanjutnya dilakukan pembacaan secara hermeneutik untuk menemukan kandungan makna atau nilai-nilai filosofi tentang keadilan soasial. Diharapkan konsep keadilan tersebut bisa digunakan sebagai referensi keadilan sosial bagi seluruh rakyat lndonesia seperti pada sila kelima Pancasila. Desa-desa yang akan digunakan sebagai objek penelitian adalah desa Kalisogo, desa Tambakoso, dan desa Terung.
POLA PEMBELAJARAN TA’LIM MUTA’ALLIM DAN IMPLEMENTASI NILAI-NILAI ETIKA BELAJAR DI PESANTREN DARUT TAUHID DUSUN ULU SUNGGAI
Authors: Urrahim Kholil
Published: February 2022

Model atau pola pembelajaran merupakan suatu perencanaan atau suatu pola yang digunakan sebagai pedoman dalam merencanakan pelajaran dikelas atau pembelajaran dalam tutolial. Model pembelajaran mengaju pada pendekatan pembelajaran yang akan digunakan, termasuk di dalamnya tujuan-tujuan pengajaran, tahap-tahap dalam kegiatan pembelajaran, lingkungan pembeljaran. Dan pengelolahan kelas Arends. Hal ini sesuai dengan pendapat joyce bahwa” Each Model Guide Us As We Design Instruction To Help Students Achieve Varios Objective”. Maksud kutipan tersebut adalah bahwa setiap model mengarahkan kita dalam merancang pembelajaran untuk membantu peserta didik mencapai tujuan pembelajaran. Sedangkan ta’limul muta’allim merupakan kitab yang mengajarkan tentang adab terhadap guru, dan dalam menuntut ilmu, serta mengamalkannya itu, menjadi kunci utama para santri menuju sukses. Implementasi adalah tindakan tindakan yang dilakukan oleh individu atau pejabat pejabat, kelompok kelompok pemerintah atau swasta yang diarahkan pada terciptanya tujuan tujuan yang telah digariskan dalam keputusan kebijakan. Etika dan moral merupakan dua istilah yang sejak dulu kala hingga sekarang terus diperbincangkan oleh para ahli, terutama di dunia filsafat dan pendidikan. Kedua istilah ini cukup menarik untuk dikaji mengingat keduanya berbicara tentang baik dan buruk, benar dan salah, atau yang seharusnya dilakukan dan yang seharusnya ditinggalkan. Etika dan moral selalu menghiasi kehidupan manusia dalam segala aspek kehidupannya.
DAMPAK MITOS MENSTRUASI TERHADAP KEHIDUPAN SOSIAL MASYARAKAT KABUPATEN PROBOLINGGO
Authors: Rahmawati Shofi , Andalas Eggy
Published: February 2022

Mitos menjadi salah satu fenomena yang kehadirannya tak dapat dihindari meski bangsa ini telah mengalami perkembangan teknologi dan juga informasi. Mitos menjadi suatu hal yang berkembang dalam ruang lingkup masyarakat dan sebagian besar sudah menjadi kepercayaan tersendiri pada setiap daerah. Penelitian berjudul “Dampak Mitos Menstruasi terhadap Kehidupan Sosial Masyarakat Kabupaten Probolinggo” ini bertujuan untuk mendeskripsikan dampak adanya mitos menstruasi dalam kehidupan sosial masyarakat Kabupaten Probolinggo. Penelitian ini merupakan penelitian kualitatif-deskriptif menggunakan pendekatan sosiologi sastra dengan sudut pandang pembaca, yang dalam penelitian ini adalah masyarakat. Data penelitian berupa hasil wawancara terhadap masyarakat Kabupaten Probolinggo yang mengetahui maupun mempercayai mengenai mitos menstruasi. Prosedur pengumpulan data dilakukan dengan (1) penentuan informan, (2) wawancara online, (3) pencatatan isi wawancara online, dan (4) perekapan hasil wawancara yang telah dilakukan. Hasil penelitian menunjukkan bahwa dampak adanya mitos menstruasi dalam kehidupan sosial mempengaruhi ketidakbebasan remaja putri dan pembatasan tingkah laku dalam melakukan kegiatan yang dilakukannya dalam kehidupan bermasyarakat. Adanya mitos menstruasi ini menjadikan remaja putri tidak leluasa dalam melakukan hal yang diinginkannya.
Crosstalk among COVID-19, STRA6, Retinol, and G protein-coupled receptor may explain the novel hypothesis of Retinol depletion and retinoid signaling disorder of COVID-19 pathogenesis
Authors: Elkazzaz mahmoud , Hayadara Tamer , Abo-Amer Yousry Esam-Eldin , Shamkh Israa M , Magd Mohammed .F. Abo El
Published: February 2022

More than two years have passed since the pandemic and despite all the efforts of researchers, the pathogenesis of COVID-19 has not yet been resolved. Multisystem involvement, neuroendocrine involvement, and pathophysiological changes caused by SARS-CoV-2 in peripheral organs have been shown in many studies. However, the molecular mechanism of these pathophysiological changes caused by COVID-19 has not been elucidated. The frequent mutations of SARS-CoV-2 and the change in the interaction of the virus with host cells have further complicated the pathogenetic mechanism in COVID-19. Unfortunately, the mechanism determined at the beginning of the pandemic and based on the single receptor tropism of ACE2 was insufficient to explain the pathogenesis of COVID-19. It is known that SARS-CoV-2 causes retinoid signaling defects and chemosensory receptor disorders and exerts its pathogenic effects through these mechanisms. Multisystem involvement and different clinical presentations in COVID-19 suggest that virus-host interaction develops through multiple receptors and signaling pathways. The previous mechanism described via ACE2, based on single-receptor tropism, was insufficient to elucidate the pathogenesis of COVID-19 due to the absence of ACE2 receptors in most of the affected organs. In addition, there is no satisfactory explanation for the mechanism by which ACE2-free organs are affected in COVID-19. In this regard, we think that ACE2 is not a true binding receptor for the SARS-CoV-2 spike protein. With our recent molecular docking studies, STRA6 and its GPCRs were identified as new binding receptors of the SARS-CoV-2 spike protein. These studies have brought a multi-receptor mechanism to the pathogenesis of COVID-19. The multi-receptor mechanism clearly illuminates the complex pathogenesis of retinoid signaling disorder, systemic organ involvement, neuroendocrine involvement, loss of smell and taste, and many other peripheral symptoms and signs, which are considered an enigma in the pathogenesis of COVID-19. Therefore, we suggest retinoid signaling defect as the main pathogenetic disorder in COVID-19 and STRA6 and GPCRs as the main binding receptors of SARS-CoV-2 spike protein. This new mechanism also clarifies the changing symptoms and findings in COVID-19 with each new variant. Moreover, these studies have explained the novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder and have revealed new drug targets for the treatment and prophylaxis of COVID-19.
Multi-receptor mechanism and retinoid signaling disorder in the pathogenesis of COVID-19
Authors: elkazzaz mahmoud ramadan
Published: February 2022

More than two years have passed since the pandemic and despite all the efforts of researchers, the pathogenesis of COVID-19 has not yet been resolved. Multisystem involvement, neuroendocrine involvement, and pathophysiological changes caused by SARS-CoV-2 in peripheral organs have been shown in many studies. However, the molecular mechanism of these pathophysiological changes caused by COVID-19 has not been elucidated. The frequent mutations of SARS-CoV-2 and the change in the interaction of the virus with host cells have further complicated the pathogenetic mechanism in COVID-19. Unfortunately, the mechanism determined at the beginning of the pandemic and based on the single receptor tropism of ACE2 was insufficient to explain the pathogenesis of COVID-19. It is known that SARS-CoV-2 causes retinoid signaling defects and chemosensory receptor disorders and exerts its pathogenic effects through these mechanisms. Multisystem involvement and different clinical presentations in COVID-19 suggest that virus-host interaction develops through multiple receptors and signaling pathways. The previous mechanism described via ACE2, based on single-receptor tropism, was insufficient to elucidate the pathogenesis of COVID-19 due to the absence of ACE2 receptors in most of the affected organs. In addition, there is no satisfactory explanation for the mechanism by which ACE2-free organs are affected in COVID-19. In this regard, we think that ACE2 is not a true binding receptor for the SARS-CoV-2 spike protein. With our recent molecular docking studies, STRA6 and its GPCRs were identified as new binding receptors of the SARS-CoV-2 spike protein. These studies have brought a multi-receptor mechanism to the pathogenesis of COVID-19. The multi-receptor mechanism clearly illuminates the complex pathogenesis of retinoid signaling disorder, systemic organ involvement, neuroendocrine involvement, loss of smell and taste, and many other peripheral symptoms and signs, which are considered an enigma in the pathogenesis of COVID-19. Therefore, we suggest retinoid signaling defect as the main pathogenetic disorder in COVID-19 and STRA6 and GPCRs as the main binding receptors of SARS-CoV-2 spike protein. This new mechanism also clarifies the changing symptoms and findings in COVID-19 with each new variant. In addition, these studies have revealed new signaling pathways and drug targets for the treatment and prophylaxis of COVID-19.
Uncertainty and sensitivity analysis for probabilistic weather and climate risk modelling: an implementation in CLIMADA v.3.1.
Authors: Kropf Chahan , Ciullo Alessio , Otth Laura , Meiler Simona , Rana Arun , Schmid Emanuel , McCaughey Jamie , Bresch David
Published: February 2022

Modelling the risk of natural hazards for society, ecosystems, and the economy is subject to strong uncertainties, even more so in the context of a changing climate, evolving societies, growing economies, and declining ecosystems. Here we present a new feature of the climate risk modelling platform CLIMADA which allows to carry out global uncertainty and sensitivity analysis. CLIMADA underpins the Economics of Climate Adaptation (ECA) methodology which provides decision makers with a fact-base to understand the impact of weather and climate on their economies, communities, and ecosystems, including appraisal of bespoke adaptation options today and in future. We apply the new feature to an ECA analysis of risk from tropical cyclone storm surge to people in Vietnam to showcase the comprehensive treatment of uncertainty and sensitivity of the model outputs, such as the spatial distribution of risk exceedance probabilities or the benefits of different adaptation options. We argue that broader application of uncertainty and sensitivity analyses will enhance transparency and inter-comparison of studies among climate risk modellers and help focus future research. For decision-makers and other users of climate risk modelling, uncertainty and sensitivity analysis has the potential to lead to better-informed decisions on climate adaptation. Beyond provision of uncertainty quantification, the presented approach does contextualise risk assessment and options appraisal, and might be used to inform the development of story-lines and climate adaptation narratives.
Vigilance: A Novel Conditioned Fear Response that Resists Extinction
Authors: Armstrong Thomas , Engel Mira , Dalmaijer Edwin S.
Published: February 2022

Attentional bias for threat is an adaptive feature of human psychology, but may become maladaptive in anxiety-related disorders, causing distress, distraction, and distorted perception of danger. Reaction time measures have revealed automatic, covert attention biases to threat, whereas eye tracking has revealed voluntary biases over a larger timescale, with monitoring or avoidance depending on context. Recently, attentional bias for threat has been studied as a conditioned fear response, providing new insight into how attentional biases are acquired and inhibited through learning experiences. However, very few studies have examined voluntary gaze biases during fear learning. In a novel eye tracking paradigm, we examine the overt components of attentional bias to threat and safety cues. We found that threat cues, but not safety cues, elicited an initial orienting bias, as well as sustained monitoring bias across 10-second trials. This collective “vigilance” response to threat cues was insensitive to extinction, whereas condition fear responding revealed by pupil size and self-report ratings showed marked extinction. Vigilance may be less prone to extinction, compared to autonomic arousal, because eye movements require less energy than preparing the body for defensive behavior. Implications for understanding vigilance in PTSD are considered.
Multifractal Mice: Operationalising Dimensions of Readiness-to-hand via a Feature of Hand Movement
Authors: Bennett Daniel Thomas , Roudaut Anne , Metatla Oussama
Published: February 2022

The philosophical construct readiness-to-hand describes focused, intuitive, tool use, and has been linked to tool-embodiment and immersion. The construct has been influential in HCI and design for decades, but researchers currently lack appropriate measures and tools to investigate it empirically. To support such empiricalwork we investigate the possibility of operationalising readinessto-hand in measurements of multfractality in movement, building on recent work in cognitive science. We conduct two experiments (N=44, N=30) investigating multifractality in mouse movements during a computer game, replicating prior results and contributing new findings. Our results show that multifractality correlates with dimensions associated with readiness-to-hand, including skill and task-engagement, during tool breakdown, task learning and normal play. We describe future possibilities for the application of these methods in HCI, supporting such work by sharing scripts and data (https://osf.io/2hm9u/), and introducing a new data-driven approach to parameter selection.
Capturing Within-Person Variability of Borderline Traits in Youth from A Developmentally Sensitive Situational Judgement Perspective
Authors: Franssens Raissa , Van Raemdonck Lisa , Abrahams Loes , Verbeke Lize , De Clercq Barbara
Published: February 2022

There is evidence on the significance of early maladaptive traits for understanding the roots of borderline personality pathology. Given the interpersonal nature of BPD and fluctuations in symptoms, the present study aims to test the assumption that a situation-contingent contextualized assessment of borderline traits is a viable avenue to capture the way underlying traits are reflected in socio-affective behavior that occurs in age-relevant situations. We aimed to explore the extent to which the variability on these responses represents a meaningful construct for understanding the clinical richness of BPD. Towards this end, a contextualized measure of DSM-5 BPD traits was developed along a situational judgement test format, allowing to explore both between-person and within-person variability in a more economic format than repeated measurement. Examination of the psychometric properties of the SJT revealed distinctive correlational patterns of the situation-based traits with symptom scales of a youth BPD measure, but also indicated that for certain traits consistency in trait-level across different situations is more maladaptive, whereas for other a greater degree of variability in trait expression is more maladaptive. Overall, the present work may set the stage for further research on the potential of SJTs for the assessment of personality pathology traits.
How Data Mining is useful in Ayurveda
Authors:   Assistant Professor, Department of Basic Principles, Faculty of Ayurveda, Parul University, Vadodara, Gujarat391760, India, Amin Hetal , Sharma Rohit ,   Assistant Professor, Department of RSBK, Abhilashi Ayurved institute and Research Centre, Abhilashi University, Mandi, Himachal Pradesh-175002, India
Published: February 2022

Data mining is a computational process of discovering patterns in large data sets involving methods at the intersection of artificial intelligence, machine learning, statistics and database systems. [1-3] The term data mining appeared around 1990 in the database community. Currently, data mining and knowledge discovery are used interchangeably.
Medicinal importance of Darbha- A review
Authors:   Assistant Professor, PG Department of Dravyaguna Vigyana, National Institute of Ayurveda, Jaipur, Rajasthan302002, India, Murthy A.Rama , Mahajon Bidhan ,   Ph.D. Scholar, PG Department of Dravyaguna Vigyana, National Institute of Ayurveda, Jaipur, Rajasthan-302002, India
Published: February 2022

Darbha is an important medicinal plant which has been used in Indian system of medicine since antiquity for the treatment of various ailments. There is enormous controversy between Kusha and Darbha in Ayurveda literature. Though the synonyms, actions and indications of Kusha, Darbha are mentioned together in different texts, the most of the Nighantus accepted both Kusha and Darbha as two different varieties and mentioned as synonyms for each other. Present study aimed to extensive review on the drug from Ayurveda as well as modern points of views. The review shows in spite of great controversy for botanical identity of this plant, most of the authors has considered Darbha as Imperata cylindrica Beauv., belongs to family Graminae. It contains various active principles like Cylindrine, Arundoin, Fermenol, Isoarborinol, Semiarenol, Cylindol A & B Gramenone A & B, Imperanene etc. On The basis of experimental and clinical studies conducted in various research centers, the drug possess various properties like diuretic, tonic, antipyretic, sedative, astringent, antiviral, vasodilator, vascular smooth muscle contraction inhibitory, plate late aggregation inhibitory properties and useful in hypertension, calculi, snake bite, thirst, gonorrhea, jaundice, diseases of blood, bladder and skin. Study may provide the scope of further research in different pharmacological area of this important medicinal plant.
Medicinal Plants and Tomorrow’s Pharmacy – Nigerian Experience
Authors:   Department of Plant Biology and Biotechnology, University of Benin, Benin City, PMB 1154, Edo State, Nigeria, MacDonald IDU
Published: February 2022

Plants are the core materials for medicines in traditional systems of healing and have been the source of creativity for numerous pharmaceutical drugs[1] . Pharmaceutical/ Synthetic drugs have gained acceptance against green remedies because of their fast-acting potency which are not without long-term side effects in most cases. However, medicinal plants work in an integrated or pro-biotic approach with little or no adverse effects on the body. For example, a steady consumption of garlic can control high cholesterol and high blood pressure within a modest period of time, but taking synthetic drugs might make an individual’s body system completely dependent on that particular medicine[2] . Interestingly, Medicinal Plants are still the backbone of 75 - 80% of the world population, predominantly in the developing countries, for primary health care[3] .
A comparative analytical study of Ashodhitha Kupilu (Strychnos nux-vomica Linn.) Shodhitha Kupilu and Vishamushti Vati.
Authors:   Final year PG Scholar, Department of Agada tantra, SDM College of Ayurveda, Kuthpady, Udupi, Karnataka574118, India, Manuprasad K.S , Honwad Sudheendra V. ,   Associate Professor & Head, Department of Agada tantra, SDM College of Ayurveda, Kuthpady, Udupi, Karnataka574118, India, swayamprabha Swapna ,   Associate Professor, Department of Agada tantra, SDM College of Ayurveda, Kuthpady, Udupi, Karnataka-574118, India, Kumar K. N Sunil ,   Senoir Research Officer, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka574118, India
Published: February 2022

Kupilu (Strychnos nux- vomica Linn), is one of the widely used drug in the category of Upavisha. Vishamushti vati is one of the preparation in which Kuiplu is the main ingredient. Kupilu shows toxic symptoms, if it is consumed without proper Shodhana procedures. Strychnine is one of the main chemical constituent available in the Kupilu by which the chemical action of Kupilu is expected. So it is very much essential to study the concentration of Strychnine in raw, Shodhitha kupilu and Vishamushti vati by means of physico-chemical analysis. Physico chemical analysis reveals increased value in loss on drying, total ash, water soluble ash, alcohol soluble extraction, water soluble extraction in Vishamushti Vati and increased value in acid insoluble ash in Ashodhitha kupilu. It is observed that Shodhitha Kupilu was less acidic than other two samples. Strychnine percentage in Ashodhitha Kupilu was 0.44, Shodhitha Kupilu was 0.14 and that of Vishamushti vati was 0.17. Hence it is proved that Shodhitha Kupilu and Vishamushti vati are having less Strychnine percentage compare to Ashodhitha Kupilu.
Characterization of pharmacognostical and preliminary phytochemical features of seeds of a Folk Plant - Gnetum ula Brongn
Authors:   P.G. Scholar, Department of Dravyaguna, SDM College of Ayurveda, Kuthpady, Udupi- 574118 India, KV Ramya Krishna , Bairy T Shridhara ,   Professor and Head, Department of PG Studies in Dravyaguna, SDM College of Ayurveda, Kuthpady, Udupi574118 India, KN Sunil Kumar ,   Senior Research Officer, Department of Pharmacognosy and Phytochemistry, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi- 574118 India, Sudhakar  ,   Research Officer, Department of Pharmacognosy and Phytochemistry, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi- 574118 India
Published: February 2022

Ayurveda opines that every plant has its own medicinal values, but there are many less explored plants which are not popular though beneficial either as food or as medicine. But this knowledge is passed from tradition to tradition in folk lore practices but within a few groups of a society. One such plant from gymnosperm group is Gnetum ula Brongn. (Gnetaceae) found commonly in and around Udupi. Locally known as kumti beeja, the plant is dioecious, branched woody climber. Seeds are roasted or boiled and consumed as food and the seed oil is used in rheumatism by folk practitioners. On account of these utilities of this less explored plant material, a detailed pharmacognostical study including macro and microscopy. Seed is enclosed by 3 layer envelope, outer fleshy and fibrous sarcotesta, hard sclerotesta and inner endosperm with two cotyledons having an embryo. Inner cotyledon contained of large parenchyma cells containing aleurone grains and starch. Preliminary phytochemical study of the seed revealed the presence of alkaloids, saponins, tannins, resin etc. HPTLC photo documentation showed a single spot under short UV, 4 spots under long UV and 3 spots under white light after derivatisation with vanillin sulphuric acid reagent. Results of this study can be utilized for identification of the drug as well as systematic document on purity standards of this extra pharmacopoeial drug.
Role of Ghandhak Jarana in the prepration of Malla Sindura -A Kupi pakwa rasayan
Authors:   Ph.D Scholar, Department of Rasashastra and Bhaishajya Kalpana including Drug Research, Institute for Post Graduate Teaching & Research in Ayurveda (IPGT & RA), Gujarat Ayurved University (GAU), Jamnagar-361008, Gujarat, India, Kumar Vivek , Tyagi Vinayak ,   Assitant QC Manager, Deltas Pharma Pvt. Ltd., F-52, Industrial Area, Haridwar- 249401, Uttrakhand, India, Patgiri BJ ,   Professor & Head, Department of Rasashastra and Bhaishajya Kalpana including Drug Research, Institute for Post Graduate Teaching & Research in Ayurveda (IPGT & RA), Gujarat Ayurved University (GAU), Jamnagar-361008, Gujarat, India, Prajapati PK ,   Director, Institute for Post Graduate Teaching & Research in Ayurveda (IPGT & RA), Gujarat Ayurved University (GAU), Jamnagar-361008, Gujarat, India
Published: February 2022

Background: Mercurial preparations known by the name of Kupipakwa Rasayana are prepared in a glass bottle by adopting gradual temperature gradient. Aims and Objectives: To elucidate the jarana process (role of temperature and time) process in kuipakwa rasayan. Materials and Methods: Two sample of Malla Sindura was prepared by heating a mixture of Parada (mercury), Gandhaka (sulfur), and Malla (arsenic) in a Kupi (glass bottle covered with mud smeared cloth) placed in an electric muffle furnace at two different temperature and time duration ie 24 and 48 hrs. Final product deposited at the neck of bottle was collected as Malla Sindura. Results and Conclusion: Three batches of each sample of Malla Sindura was prepared by adopting gradient temperature pattern for 24 hrs and 48 hrs i.e., 8 h of mild (120-250°C), moderate (250-450°C) and strong heating (450-600°C) for SDMS and 18 hrs of mild (140-250°C), 22 hrs moderate (250-450°C) and 8 hrs strong heating (450-630°C) for LDMS each. Average yield of Malla Sindura in two samples is 151.33 g (37.83%) and 237.7 g (59.42%) using 400 g Kajjali in each batch respectively.
Evaluation of the antimalarial activity of Curcuma longa Linn., singly and in combination with Eupatorium odoratum Linn.
Authors:   Department of Biotechnology, Technological University, Kyauk-Se, Myanmar, Lwin Khin Myat , Mon Hla Myat ,   Departmentof Biotechnology, Mandalay Technological University, Patheingyi, Myanmar, Myint Khin Htay ,   Pharmaceutical Research, Technological University, Kyauk-Se, Myanmar
Published: February 2022

Following the observation of in vitro anti-malarial activity of the ethanolic extract of Curcuma longa Linn., the active compound was isolated from its rhizome and detected in vitro, the results showed that schizont suppression of 62.63% even at the lowest concentration 0.625 µg/ml on human malaria with IC50 values of <0.625ug/ml. Another test sample extract of Eupatorium odoratum Linn, revealed that the significant antimalarial activity with IC50 value of 0.8581 ug/ml. The combination of C. longa and E. odoratum was found to be IC50 of <0.625 µg/ml showing their probable synergistic effect on the human malaria parasite. The extract and isolated compound of C. longa was further tested for their antimalarial activity using Plasmodium berghei mouse model. The highest in vivo parasite suppression was found to be 67.9% and 72.97% at the dosage of 50 mg/kg body weight for C. longa extract and isolated compound respectively. Moreover, brine shrimp toxicity test and in vivo toxicity test in mice showed no lethal effect of both C. longa and E. odoratum at the tested concentration which is moderately high. The results showed that both plant samples are potentially safe and possess prospective anti-malarial activity. It can be used as a single or combination.
Pharmacognostic and preliminary physicochemical study of vidangadilouham- an ayurvedic antidiabetic herbomineral preparation
Authors:   Assistant Professor, Bengal Institute of Pharmaceutical Sciences, Kalyani, West Bengal- 741235, India, Debnath Monojit , Chaudhuri Samyak ,   B.Pharm (Ayur) Scholar, Bengal Institute of Pharmaceutical Sciences, Kalyani, West Bengal- 741235, India, Nanda Amalesh ,   B.Pharm (Ayur) Scholar, Bengal Institute of Pharmaceutical Sciences, Kalyani, West Bengal- 741235, India, Biswas Moulisha ,   Assistant Professor, Bengal Institute of Pharmaceutical Sciences, Kalyani, West Bengal- 741235, India, Haldar Pallab Kanti ,   Associate Professor, Bengal Institute of Pharmaceutical Sciences, Kalyani, West Bengal- 741235, India
Published: February 2022

Vidangadilouham is a very famous ayurvedic herbo-mineral compound formulation generally prescribed in powder form and directed to take with some vehicle like water, honey, jiggery, milk etc. It is indicated in various ayurvedic treatises for various disorders like prameha (diabetes), sotha (inflammation), pandu (anaemia), halimak (advanced or neglected stage of anemia), medoroga (hyperlipidaemia), kamla (jaundice) etc. The ingredients of vidangadilouham are vidanga (Embelia ribes), amla (Emblica officinalis), haritaki (Terminalia chebula), bahera (Terminalia bahera), krishnajeeraka (Nigella sativa), swetajiraka (Cuminum cyminum), sunthi (Zingiber officinale), mustaka (Cyperus rotundus), pippali (Piper longum) and Louhabhasma (Incinerated iron).In the present study the pharmacognostic and basic physicochemical study of the plant drugs including phytochemical screenings had been performed. The samples were collected from authentic suppliers in dried and crude form and the macroscopic study was performed first. Then these were subjected for powdering in pulveriser and sieved through 80 #. The powdered material was subjected for microscopic study and the identification characters for each sample were noted carefully with proper illustrations. All the powdered drugs were mixed carefully with louhabhasma and thoroughly triturated well. The microscopic study and physicochemical tests of the finished product was also carried out. The data obtained from this study further may be used as a source of standard monograph for vidangadilouham.
Quality assessment of an Ayurvedic formulation: Potaki Taila
Authors:   Senior Lecturer, Department of Prasutitantra Kaumarabhritya, Institute of Indigenous Medicine, University of Colombo, Sri Lanka, YAUD Karunarathne , Srivastav P ,   Associate Professor, Department of Biochemical Engineering, Banaras Hindu University, Varanasi, India, Chaudhary A ,   Associate Professor, Department of Rasa Shastra, Banaras Hindu University, Varanasi, India, Dwivedi M ,   Professor, Department of Prasuti Tantra, Banaras Hindu University, Varanasi, India, LDAM Arawwawala ,   Principal Research Scientist, Industrial Technology Institute, Bauddhaloka Mawatha, Colombo, Sri Lanka
Published: February 2022

Background: Quality assessment of herbal drugs is becoming very important in the world. Potaki Taila has mentioned for Sukha Prasava in Bhavaprakasha Yoni Roga Chikitsa. The main ingredients in Potaki Taila are roots of Basella alba and seed oil of Sesamum indicum. Quality assessment of Potaki Taila has not been done before. Objective and Methodology: The aim of the present study was to assess the quality of Potaki Taila by using standard protocols. Results: Average values of refractive index, viscosity, iodine value, saponification value, acid value, peroxide value, free fatty acid value and total fatty matter were noted as 1.471, 6.073 × 10- 4 sec, 43.0 g per 100 g, 149.2 mg/g, 1.1 mg KOH/g, 0.33 Meq/kg, 0.1 %, and 82.6 % respectively. Conclusion: Physico-chemical parameters of Potaki Taila were established for the first time and output of the present investigation may be used as reference standard for the Potaki Taila.
Alopecia areata (Indralupta): A case successfully treated with ayurvedic management
Authors:   Assistant Professor, Departemnt of Rasashastra and Bhaishajya Kalpana Including Drug Research, I.P.G.T. & R.A., G.A.U., Jamnagar, Gujarat-361008, India, Shingadiya Rahul , Bedarkar Prashant ,   Assistant Professor, Departemnt of Rasashastra and Bhaishajya Kalpana Including Drug Research, I.P.G.T. & R.A., G.A.U., Jamnagar, Gujarat-361008, India, Varsakiya Jitendra ,   Assistant Professor, Departemnt of Kaya Chikitsa, J S Ayurved Mahavidhyalaya, Nadiad, Gujarat-361008, India, Patgiri BJ ,   Professor and Head, Departemnt of Rasashastra and Bhaishajya Kalpana Including Drug Research, I.P.G.T. & R.A., G.A.U., Jamnagar, Gujarat-361008, India, Prajapati PK ,   Dean and Professor, Departemnt of Rasashastra and Bhaishajya Kalpana Including Drug Research, All India Institute of Ayurveda, New Delhi, Delhi- 110076, India
Published: February 2022

Alopecia areata, an autoimmune disease characterised by hair loss can be correlated with Indralupta in Ayurveda. Due to side effects and limitation of the contemporary science, some harmless and effective medicines are expected from Alternative medical sciences. Ayurveda has great potential to treat such autoimmune diseases. Here a case of alopecia areata successfully treated with Ayurvedic management is recorded.
Review on Trisama- an unexplored ancient ayurvedic formulation
Authors:   Pharmacology Laboratory, Institute of Post Graduate Teaching & Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat-361008, India, Patel Amit G. , Nariya M.B. ,   Pharmacology Laboratory, Institute of Post Graduate Teaching & Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat-361008, India, Shukla V.J. ,   Pharmaceutical Chemistry Laboratory, Institute of Post Graduate Teaching & Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat-361008, India, Patel B.R. ,   Assistant Professor, Dept. of Dravyaguna, Institute of Post Graduate Teaching & Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat-361008, India
Published: February 2022

Indian system of medicine has a longstanding history of using medicinal plants for the prevention and treatment of various health ailments. Trisama is an ancient Ayurvedic preparation can be prescribed for a wide range of disorder but not popular as many other Ayurvedic herbal formulations. Trisama is preparing by mixing the Sunthi (Zingiber officinale Linn.), Haritaki (Terminalia chebula Retz.), and Guduchi (Tinospora cordifolia Willd Meirs) in equal proportion. It is credited with diverse beneficial therapeutic effects mainly as Shothhara and Amapachana and reported to possess many pharmacological properties due to its common Usna Virya and Madhur Vipaka of the individual ingredients. The reported pharmacological effects of its ingredients are anti-oxidant, anti-inflammatory, anti-pyretic, analgesic, antimicrobial, hypolipidemic, cardioprotective, gastroprotective, cytoprotective effects etc. The bioactive components responsible for these therapeutic potential are mainly due to the presence of major important phytoconstituents such as phenolics components like gingerols, gingerdiols and gingerdione, shogaols, zingiberine, giloin, berberine, tinosporin, tinosporin acid and gallic acid. The present review focuses on summarizing the formulation details by their Ayurvedic properties, phytoconstituents and pharmacological activity. The review suggests that, Trisama formulation is easily available, economical, palatable and more beneficial for human health.Hence, it may be popularize among general Practitioner as an important Ayurvedic medicine in the form of churna (powder) and kwatha (decoction) for the treatment of Sotha and metabolic disorders.
Gentiana lutea Linn. (Yellow Gentian): A comprehensive review
Authors:   Goel Institute of Pharmacy and Sciences, Faizabad Road, Lucknow, Uttar Pradesh - 226016, India, Prakash Om , Singh Ruchi ,   Goel Institute of Pharmacy and Sciences, Faizabad Road, Lucknow, Uttar Pradesh - 226016, India, Kumar Saroj ,   Goel Institute of Pharmacy and Sciences, Faizabad Road, Lucknow, Uttar Pradesh - 226016, India, Srivastava Shweta ,   Goel Institute of Pharmacy and Sciences, Faizabad Road, Lucknow, Uttar Pradesh - 226016, India, Ved Akash ,   Goel Institute of Pharmacy and Sciences, Faizabad Road, Lucknow, Uttar Pradesh - 226016, India
Published: February 2022

Gentiana lutea Lin. commonly known as yellow gentian, bitter root and bitterwort belonging to family Gentianaceae is a common traditional medicine freely available in hilly areas in Japan, Europe and adjoining continents, its medicinal properties are also mentioned in Ayurveda. The plant is reported to posse’s antioxidant, antifungal, anti-inflammatory, stomachic, appetizer and immunomodulatory properties etc.Gentiana lutea is an important source of bitter phytoconstituents such as amarogentin, gentiopicrinor gentiopicroside, gentiolutelin and its dimethyl acetal, gentioluteol, gentanine, amaroswerin, gentioside including a new iridoid named gentiolutelin. Traditionally the plant is used as stomachic tonic, bitter tonic, dyspepsia, gastric inefficiency in infants, digestive tonic, catarrhal diarrhoea, anaemia, malarial disease etc. The present review is an effort to generate an interest among the mosses regarding its immense potential in preventing and treating several diseases.
Significance of Puta in Bhasmikarana with special reference to Sankha Bhasma
Authors:   PG Scholar, Department of Rasashastra and Bhaishajya Kalpana, School of Ayurveda, Amrita University, Amritapuri, Kerala, India, V Sreeja Kaimal , Vineeth PK ,   Assistant Professor, Department of Rasashastra and Bhaishajya Kalpana, School of Ayurveda, Amrita University, Amritapuri, Kerala, India, Ramesh NV ,   Professor, Department of Rasashastra and Bhaishajya Kalpana, School of Ayurveda, Amrita University, Amritapuri, Kerala, India, Pillai K Unnikrishna ,   Professor, Department of Rasashastra and Bhaishajya Kalpana, School of Ayurveda, Amrita University, Amritapuri, Kerala, India
Published: February 2022

Rasashastra is the branch which deals with drugs of metals and mineral origin. According to Rasashsastra, procedures like shodhana and marana are employed to detoxify the metals and minerals. Traditionally Puta is used in the marana procedure used to obtain bhasma. Sankha is an animal product which is included in sudha varga. Main chemical constituent of sankha bhasma is calcium carbonate. Sankha bhasma is done usually through puta process which is the best method as per our Acharyas to enhance its therapeutic efficacy.
A review on pharmaceutically important medical plant: Plumbago zeylanica
Authors:   Plant Biotechnology Laboratory, Department of Biotechnology, Delhi Technological University, New Delhi-110042, India, Roy Arpita , Bharadvaja Navneeta ,   Plant Biotechnology Laboratory, Department of Biotechnology, Delhi Technological University, New Delhi-110042, India
Published: February 2022

Medicinal plants have been used as a source of medicine and they are in great demand worldwide. They have been used for many years to treat health disorders and prevent diseases. Plumbago zeylanica is one of the medicinal plants which are widely used for its therapeutic value. It contains several bioactive compounds like napthoquinones, flavonoids, alkaloids, glycosides, steroids, tri-terpenoids, tannins, fixed oils, fats, proteins, etc among all plumbagin is most important bioactive compounds. It possesses wide range of pharmaceutical activities such as anti-cancer, antidiabetic, anti-malarial, anti-microbial, etc. Several studies have been done in evaluation of its pharmaceutical activities. The aim of the present review is to provide a comprising knowledge related to the chemical composition and pharmaceutical activity of P. zeylanica.