bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulation and Verification of Vertical Heterogeneity Spectral Response of Winter Wheat Based on the mSCOPE Model
Authors: Huang Linsheng , Zhang Yuanyuan , Yang Guijun , Liang Dong , Li Heli , Li Zhenhai , Yang Xiaodong
Published: August 2020

Vertical heterogeneity of the biochemical characteristics of crop canopy is important in diagnosing and monitoring nutrition, disease, and crop yield via remote sensing. However, the research on vertical isomerism was not comprehensive. Experiments were carried out from the two levels of simulation and verification to analyze the applicability of this recently development model. Effects of winter wheat on spectrum were studied when input different structure parameters (e.g., leaf area index (LAI)) and physicochemical parameters (e.g., chlorophyll content (Chla+b) and water content (Cw)) to the mSCOPE (Soil Canopy Observation, Photochemistry, and Energy fluxes) model. The maximum operating efficiency was 127.43, when the winter wheat was stratified into three layers. Meanwhile, the simulation results also proved that: the vertical profile of LAI had an influence on canopy reflectance in almost all bands; the vertical profile of Chla+b mainly affected the reflectivity of visible region; the vertical profile of Cw only affected the near-infrared reflectance. The verification results showed that the vegetation indexes (VIs) selected of different bands were strongly correlated with the parameters of the canopy. LAI, Chla+b and Cw affected VIs estimation related to LAI, Chla+b and Cw respectively. The Root Mean Square Error (RMSE) of the new-proposed NDVIgreen was the smallest, which was 0.05. Sensitivity analysis showed that the spectrum was more sensitive to changes in upper layer parameters, which verified the rationality of mSCOPE model in explaining the law that light penetration in vertical nonuniform canopy gradually decreases with the increase of layers.
Exploring the Application of the FOX Model to Foster Pro-Environmental Behaviours in Smart Environments
Authors: Irizar-Arrieta Ane , Casado-Mansilla Diego , Retegi Aiur , Laschke Matthias , López-de-Ipiña Diego
Published: August 2020

The heterogeneity and dynamism of people make addressing user diversity and its categorisation critical factors, which should be carefully considered when developing pro-environmental strategies and interventions. Nevertheless, the complexities of individuals complicates the creation of modelling and classification systems. The aforementioned issue opens a research opportunity, which should be tackled to improve the development of human-centric systems and processes. Throughout the present piece of research, our objective is to bridge that gap by extracting knowledge and insights relating to how to address user diversity when designing technologies considering sustainable behaviour. For this, we explore the possibilities of the FOX model—an early meta-model to approach the diversity of individuals when addressing pro-environmental behaviour—to classify and understand individuals while taking their heterogeneity into account. After introducing the model, a qualitative survey of eight experts is conducted. From this study, relevant findings are analysed and exposed. Taking into account the gathered knowledge, three user profiles are developed, based on the dimensions proposed by the model. Furthermore, scenarios are created for each profile, presenting three case studies where different application modes of the model are described (personalised interventions, prediction and forecasting, and individual and collective interventions). Finally, the extracted findings are analysed, discussing the main issues related to the development of pro-environmental technologies and systems.
A Procedure for Complete Census Estimation of Rooftop Photovoltaic Potential in Urban Areas
Authors: Pinna Andrea , Massidda Luca
Published: August 2020

Rooftop photovoltaic solar systems can be an essential tool to support the energy transition of Europe. The assessment of solar power generation potential in urban areas, necessary for smart grid planning, requires the processing of data of different types, such as building cadastral information, a detailed description of available roof areas, and solar irradiation data. We introduce an algorithm for the fast calculation of the building’s shadows and a procedure for the integration of solar irradiation in time. We therefore develop a methodology that allows a fast evaluation with minimal computational resources, and we apply it to an urban scenario of a medium-sized European city obtaining an estimate of the complete census PV power generation potential, with a spatial resolution of 1 m. We validate the results by comparison with a reference procedure, obtaining minimal deviation with a much lower demand for computational resources.
Transnational Advocacy Networks of Migrants and Asylum Seekers’ Human Rights: The San Diego—Tijuana Border in the Trump Era
Authors: Stoesslé Philippe , Patiño Díaz Valeria , Rosales Martínez Yetzi
Published: August 2020

How do advocacy organizations from the San Diego—Tijuana area contest and resist Trump’s immigration policies? What resources and tactics do they use to externalize their demands at the local and international levels? Based on semi-structured interviews with eight advocacy organizations—with a local, binational, and international presence—that have mobilized to externalize their demands on different local and international arenas, this research aims to answer these questions by applying the transnational advocacy networks literature to the mentioned case study. Our main findings show that transnational relations between advocacy organizations represent a counterbalance to Trump’s immigration policies. Some organizations have adapted to react to a set of new policies implemented by the administration, and, at the same time, they have diffused information, values, and ideas as part of their resistance tactics. Through transnational advocacy networks, local organizations have accomplished international relevance, turning into key players of advocacy in the region. These networks demonstrate that, despite Trump’s restricting immigration policies, transnational channels between these actors remain open for collective action.
Sanctuary Cities: What Global Migration Means for Local Governments
Authors: Manfredi-Sánchez Juan Luis
Published: August 2020

Cities have become active participants in implementing migration policies, thereby expanding the meaning of the word “global” with regard to the activity of local governments. International movement tends to flow toward and converge on metropolitan areas. This paper discusses the role of cities in immigration policy by taking into consideration legitimacy, authority, and public governance. Under Donald Trump’s crackdown on sanctuary cities, this study sheds light on implementation policies worldwide, and on the role of social demands in opening cities to migrants. Finally, the sovereignty-free approach explains why cities like San Francisco and Barcelona have opposed national foreign policy.
Safety Attitude as a Predictor of the Sense of Threat in the Workplace, Using the Example of Airport Ground Staff
Authors: Dobrowolska Małgorzata , Stasiła-Sieradzka Marta , Kozuba Jarosław
Published: August 2020

In its development, air transport is obliged to take into account guidelines related to its sustainability. An important element thereof consists of making sure that the working conditions for all the workers employed in this sector are safe and healthy. The aim of this research was to analyze the relationship between the attitude towards safety and the perceived feeling of threat in the workplace among respondents belonging to the airport ground staff occupational group. The research verified the following: 1. whether a relationship exists between the safety attitude (in the following dimensions: affective, cognitive, and behavioral) and the feeling of threat in the workplace (in the following dimensions: internal discomfort related to the fear of potential threats, the fear of current threats, and seeking to avoid threats); 2. whether attitudes towards safety act as predictors of the feeling of threat in the workplace. A total of 299 individuals took part in the research. Purposive sampling was used, based on criteria related to the respondents being members of airport ground staff. The Safety Attitudes Questionnaire by M. Znajmiecka-Sikora was used in the research. The feeling of threat was assessed using Feeling of Threat at Work Questionnaire by Mamcarz. The results obtained confirmed the assumed negative correlation between the main variables, and at the same time they revealed that among the studied safety attitude components, only the affective component makes it possible to predict the general feeling of threat, being its negative predictor (β = −0.14; s.e. = 0.33; t = −2.27; p = 0.024). The affective component of the safety attitude also constituted a negative predictor of one of the dimensions of the studied feeling of threat, namely seeking to avoid threats (β = −0.22; s.e. = 0.17; t = −3.66; p < 0.001).
Development of Flood Risk and Hazard Maps for the Lower Course of the Siret River, Romania
Authors: Arseni Maxim , Rosu Adrian , Calmuc Madalina , Calmuc Valentina Andreea , Iticescu Catalina , Georgescu Lucian Puiu
Published: August 2020

The Siret River is one of the most important tributaries of the Danube River in the Romanian territory. With a total length of 596 km in this territory, the confluence section of the Siret River with the Danube represents an area where major floods have occurred over time. In the last 50 years, over 20 floods have been recorded in the lower area of the Siret River; and the most recent important flood, which happened in 2010, had a negative impact on the local population, the environment, and the economy. Although it is a buffer zone, the Danube River has a significant impact on the discharge rate of the Siret River. Since few studies have been conducted on the prediction of flooding in the lower area of the Siret River, the present study aims at presenting the most important steps to be taken for designing risk and hazard maps for floods, which could be further applied to other rivers. The confluence of the Siret River with the Danube, a distance of 35 km upstream, was chosen as a study area. Techniques of topographic and bathymetric measurements were combined in order to design the risk and hazard maps for floods in this area and to improve the digital terrain model of the minor riverbed for the studied river area. The 1D hydrodynamic model of the HEC-RAS software was used in this research for developing the flood risk and flood hazard maps. The hazard and risk maps were generated based on 10%, 5%, and 1% flood scenarios, which are in accordance with Floods Directive 2007/60/EC; no historical data were available for the 0.1% scenarios. Thus, in a flood scenario that can occur every 100 years, about 9500 inhabitants are vulnerable at a medium flood risk. In this scenario, over 19.5 km of road infrastructure, about 16.5 km of railways, eight cultural heritage indicators, and three environmental indicators may be affected.
Does Servant Leadership Moderate the Relationship between Job Stress and Physical Health?
Authors: Dooley Larry M. , Alizadeh Amin , Qiu Shaoping , Wu Hongchao
Published: August 2020

High school teachers experience high levels of job stress, which could lead to serious health problems. This study focused on Chinese high school teachers, as they have to manage negative stress and health issues. The research aimed to: (1) investigate the relationship between hindrance job stress, depersonalization, and physical health; (2) investigate if servant leadership, in fact moderates the relationship between hindrance job stress and depersonalization, as well as physical health. The study desisgn was cross-sectional and data analyses were conducted by using SPSS 21 and Mplus 7. The sample consisted of 857 high school teachers across Southern China. The results showed that hindrance stress is related to depersonalization among high school teachers (β = 0.63, p < 0.01). Both hindrance job stress (β = 0.32, p < 0.01) and depersonalization (β = 0.16, p < 0.01) are positively related to physical health. In addition, servant leadership moderates the relationship between hindrance job stress and physical health among the Chinese high school teachers (β = −0.09, p < 0.01). However, the results did not find that the effect of hindrance job stress on depersonalization is moderated by servant leadership (β = 0.02, p = 0.53). It is suggested that Chinese high schools recruit and train leaders in servant leadership, relieve teachers’ stress, and promote their health to ensure the sustainable development of schools.
Effect of Viewing Real Forest Landscapes on Brain Activity
Authors: Song Chorong , Ikei Harumi , Kagawa Takahide , Miyazaki Yoshifumi
Published: August 2020

Benefits related to health promotion by getting closer to forests have received increasing attention in modern stressful society; however, evidence-based research about how our brain activity changes when we stay in a forest environment is limited. Thus, the goal of this study was to evaluate the influence of viewing real forest landscapes on the activity in the prefrontal cortex area of young women’s brains. The experiment included 29 women (age: 21.0 ± 1.4 years) and was executed in five forest and five urban areas. The participants stayed in the forest and urban areas and viewed each view for 15 min. While viewing scenery, they had the oxyhemoglobin (oxy-Hb) concentrations in the left and right areas of their prefrontal cortexes measured continuously. Viewing real forest landscapes was associated with a significantly lower oxy-Hb concentration in the right area of the prefrontal cortex than when seeing urban areas. In conclusion, viewing real forest landscapes substantially diminished oxy-Hb concentrations in the right area of the prefrontal cortex, which is linked to physiological relaxation.
Black-Hole Models in Loop Quantum Gravity
Authors: Bojowald Martin
Published: August 2020

Dynamical black-hole scenarios have been developed in loop quantum gravity in various ways, combining results from mini and midisuperspace models. In the past, the underlying geometry of space-time has often been expressed in terms of line elements with metric components that differ from the classical solutions of general relativity, motivated by modified equations of motion and constraints. However, recent results have shown by explicit calculations that most of these constructions violate general covariance and slicing independence. The proposed line elements and black-hole models are therefore ruled out. The only known possibility to escape this sentence is to derive not only modified metric components but also a new space-time structure which is covariant in a generalized sense. Formally, such a derivation is made available by an analysis of the constraints of canonical gravity, which generate deformations of hypersurfaces in space-time, or generalized versions if the constraints are consistently modified. A generic consequence of consistent modifications in effective theories suggested by loop quantum gravity is signature change at high density. Signature change is an important ingredient in long-term models of black holes that aim to determine what might happen after a black hole has evaporated. Because this effect changes the causal structure of space-time, it has crucial implications for black-hole models that have been missed in several older constructions, for instance in models based on bouncing black-hole interiors. Such models are ruled out by signature change even if their underlying space-times are made consistent using generalized covariance. The causal nature of signature change brings in a new internal consistency condition, given by the requirement of deterministic behavior at low curvature. Even a causally disconnected interior transition, opening back up into the former exterior as some kind of astrophysical white hole, is then ruled out. New versions consistent with both generalized covariance and low-curvature determinism are introduced here, showing a remarkable similarity with models developed in other approaches, such as the final-state proposal or the no-transition principle obtained from the gauge-gravity correspondence.
Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review
Authors: Nicolai Michele , Lassandro Nicola , Franceschi Alessandro , Rosati Alessandro , De Turris Serena , Pelliccioni Paolo , Pirani Vittorio , Mariotti Cesare
Published: August 2020

Silicone oil represents the main choice for intraocular tamponade in cases of complicated retinal detachment surgery. The intraocular pressure of an eye filled with silicone oil could increase, driven by a variety of different forces, according to several mechanisms. Two main conditions have been highlighted, depending on the onset: early hypertension or late glaucoma. The different types of silicone oils and their physico-chemical properties are varied and may play a role in the determination of intraocular pressure rise. The current body of literature allows for the illustration and categorization of the incidence and risk factors, as well as the pathogenesis and the management of the early postoperative hypertension subtended by an open- and closed-angle, along with the late onset silicone oil-induced glaucoma. Understanding the leading actors on the stage of ocular pressure elevation concurrently with silicone oil application for retinal surgery could help in guiding the timely and appropriate course of treatment.
Нормативно-правова регламентація обмеження свободи пересування в умовах надзвичайної ситуації в Україні
Authors: Славна О.
Published: August 2020

Стаття присвячена дослідженню чинного законодавства України в межах запровадження надзвичайної ситуації, яка передбачає введення карантинних заходів і як наслідок тимчасово обмежує право на свободу пересування. Обґрунтовано позицію, що право на свободу пересування не є абсолютним і може бути обмежене за умови закріплення таких обмежень у відповідному законі. В рамках аналізу нормативно-правових актів, зроблений висновок, щодо відсутності виключного переліку випадків обмеження свободи пересування, що може призвести до нівелювання сутності та змісту фундаментального конституційного права людини на свободу пересування.
Режим – це не «порядок виконання і відбування покарання», а програма соціальної допомоги при поводженні з ув’язненими
Authors: Степанюк А.
Published: August 2020

У кримінально-виконавчому праві України усталеною є думка, що режим у виправних і виховних колоніях – це є порядок виконання і відбування покарання. Таке розуміння режиму має свої історичні корені у радянському гулагівському минулому. Саме з 30-х років минулого сторіччя за наказами й інструкціями НКВС режим для засуджених став втіленням порядку виконання і відбування позбавлення волі на підставі їх ізоляції. З того часу і по сьогоднішній день забезпечення ізоляції засуджених розглядається як основна вимога режиму. У радянському виправно-трудовому праві виходили з того, що ізоляція уособлює в собі обмеження прав і свобод притаманних позбавленню волі, тобто кару. Режим вимагає здійснювати нагляд за позбавленими волі шляхом цілодобового і постійного контролю в місцях їх проживання і праці. Засобами забезпечення режиму є обшуки засуджених та приміщень, в яких вони знаходяться, огляд території колонії; застосування до позбавлених волі заходів фізичного впливу, спеціальних засобів і зброї. На відміну від такого розуміння режиму, Європейські тюремні правила (ЄТП) розрізняють ув’язнення і позбавлення волі і виходять з того, що ув’язнення і позбавлення волі є покаранням вже самі по собі і тому режим для засуджених ув’язнених не повинен збільшувати страждання, заподіяні ув’язненням. Режим за ЄТП складається зі збалансованої програми консультацій, піклування, турботи і допомоги, спрямованої на полегшення реінтеграції ув’язнених у вільне суспільство після закінчення їхнього строку ув’язнення. Режим передбачає надання можливості отримання освіти, професійної підготовки , заняття спортом, організації відпочинку. ЄТП далекі від того, щоб розглядати режим як порядок виконання і відбування покарання. За ЄТП режим є правилами поводження з ув’язненими, саме так має тлумачитися режим і у кримінально-виконавчому праві України. Актуальність дослідження даного аспекту режиму зумовлена необхідністю розробки пропозицій у галузі кримінально-виконавчого права, які б відповідали законодавству Європейського Союзу, що передбачено Концепцією реформування (розвитку) пенітенціарної системи України.
Історико-правове дослідження міліції України передвоєнного десятиліття (1931–1941 роки)
Authors: Кириченко В.
Published: August 2020

Рецензія на книгу: Бандурка О. М., Греченко В. А. Міліція в Україні в період посилення тоталітарного режиму (1931–1941 рр.): історико-правове дослідження: [монографія]. Харків : Золота миля; Панов, 2020. 444 с.
ANALISIS PENERAPAN PMK NO.136/PMK.03/2012 TENTANG PENUNJUKAN BUMN SEBAGAI WAPU PPN (Studi Pada PT. Pertamina Geothermal Energi Area Kamojang)
Authors: Saadah Kamalah , Wati Norma Etika
Published: August 2020

This study aims to determine the description and analysis of the application of PMK No.136 / PMK.03 / 2012 which includes payment, deposit and reporting procedures for Value Added Tax at PT Pertamina Geothermal Energy (PGE) Kamojang Area. The method used in this research is descriptive qualitative method with data collection techniques by observation, interview and documentation. Data sources used in this study are primary and secondary data. This study produces a description that the obligations of PT PGE Kamojang Area as a Value Added Tax Taxpayer have been carried out properly in accordance with PMK No.136 / PMK.03 / 2012, but at the time of its implementation found errors from partner companies which resulted in delays. Further impacts will lead to the imposition of administrative fines for both parties. This research is expected to contribute input regarding Value Added Tax for PT PGE Kamojang Area to become a more orderly company in tax administration. The observations that have been made show that there are some discrepancies in the implementation of the Value Added Tax payment procedure. As a result, if it is not met, there will be sanctions for the delay in depositing and reporting the tax.
miR-515-5p and Notch1 as New Diagnostic Markers of Hepatocellular Carcinoma
Authors: Asefy Zahra , Hoseinnejhad Sirus , Dolati Sanam , Ceferov Zaker , Hasanzadeh Amir , Azergun Robab , Nouri Mohammad
Published: August 2020

Background: Modifications of miRNA expression have been related to various types of cancers including hepatocellular carcinoma (HCC). miRNAs directly act as repressors of gene expression, as they reside in fragile sites, as well as cancer-related genomic regions. Notch signaling is a conserved evolutionary pathway that controls cell functions. The dysregulation of this pathway leads to different diseases such as cancer. Objectives: This study aimed to investigate the role of miR-515-5p and Notch1 as new diagnostic markers in HCC. Methods: Forty formalin fixed paraffin embedded (FFPE) autopsy blocks and 40 FFPE normal liver tissues were selected from the archives of the pathology of Imam Reza hospital, Tabriz, Iran. Real-time polymerase chain reaction (PCR) was used for gene expression. Immune histochemistry method was used for detecting notch1 in normal and cancer FFPE tissues. Hematoxylin and eosin staining was also used for the diagnosis of normal and cancerous tissues. Results: miR-515-5P showed higher expression in the cancer group compared to the normal group (4.7 fold). Hematoxylin and eosin staining of HCC tissues showed significant color intensity than that of normal tissues. Immune histochemistry results revealed significant Ag-Ab reaction in the cancer group. In this study, we analyzed miRNA gene expression and notch 1 level in HCC patients. miRNA dysregulation has been found in a large variety of HCCs. Hepatocarcinogenesis was associated with the expression level of miR-515-5p with carcinogenesis. Moreover, notch1 was a key protein in liver cell fate and a progressive molecule in HCC. Conclusion: Our study demonstrated the main role of miR-515-5p in the pathogenesis of HCC. Likewise, it disclosed the expression of these genes could be utilized in HCC prognosis.
Role of Pre-molten Globule Structure in Protein Amyloid Fibril Formation
Authors: Es-haghi Ali , Jahedi Moghaddam Mahsa , Shahpasand Koorosh
Published: August 2020

The conversion of a protein from its native conformation to the pathogenic form is a critical event in the pathogenesis of several neurodegenerative disorders such as Alzheimer’s (AD), Parkinson’s, and Huntington’s diseases, along with type II diabetic mellitus. Although there are several reports on the mechanism of protein aggregation, the actual conformation playing a part in the pathogenicity is yet unclear. Accordingly, the present study summarizes the early pathogenic conformation resulting in several protein aggregations. It is well-documented that a pre-molten globule (MG) structure appears at the early stages of some proteins. Pre-MG is one of the intermediate structures, which is formed during some protein unfolding processes. In addition, it is shown that the pre-molten structure is more flexible than the mature MG one and thus, protein easily rearranges to form amyloid fibrils in this conformation. Therefore, protein aggregation is halted by preventing the pre-MG structure. The strategy of protein aggregation prevention has profound implications in fighting the devastating disorder.
Assessment of Iron Metabolism-Related Parameters in Obese Children
Authors: Donma Mustafa Metin , Güngör Zeynep Ersöz , Yılmaz Ahsen , Guzel Savas , Donma Orkide
Published: August 2020

Objectives: The aim of the study was to assess the possible associations among biochemical parameters that may be correlated with the possible mechanisms of iron metabolism in healthy children with normal body mass index (BMI), along with morbid obese (MO) children with and without metabolic syndrome (MetS). Methods: To this end, children aged 6-18 years with no history of any acute or chronic diseases were selected as the population of this prospective case-control study. Thirty MO children (with BMI higher than 99th percentile and without MetS findings), 28 MO children (with BMI higher than 99th percentile and with MetS), and 30 healthy children (with BMI values between 15th and 85th percentiles) participated in the study. Then, anthropometric measurements were recorded, followed by performing the complete blood count and serum iron profile. In addition, ferritin, transferrin, hepcidin, irisin, ferroportin, brain-derived neurotrophic factor (BDNF), WISP1, and PTP1/fortilin levels were measured using ELISA. Finally, statistical analyses were performed and P<0.05 was considered as the level of statistical significance. Results: Significant differences were obtained among the groups regarding anthropometric measurements, blood pressures, triacylglycerols, and high-density lipoprotein cholesterol levels. Further, there was a tendency toward an iron deficiency in both MO groups while an increase in ferritin levels was significant in the MetS group. However, BDNF, hepcidin, and ferroportin demonstrated no significant difference among the groups. Eventually, although the above-mentioned parameters were statistically insignificant, fortilin levels indicated a gradual decrease whereas irisin levels represented an increase from control group toward morbid obesity and MetS. Conclusion: In our study, obesity severity and the tendency toward iron deficiency were in accordance with each other. Particularly, different WISP-1 levels in the groups may help predict future complications, along with its use in diagnosing obesity.
Effect of 8-Week Interval Training on Protein Tyrosine Phosphatase 1B Expression in Gastrocnemius Muscle and Insulin Resistance in Rats with Type 2 Diabetes
Authors: Eizadi Mojtaba , Mirakhori Zahra , Farajtabar Behrestaq Saqqa
Published: August 2020

Background: Insulin resistance induced by genetic and metabolic disorders is the main cause of the prevalence or severity of type 2 diabetes (T2D). Protein tyrosine phosphatase 1B (PTP1B) plays a key role in regulating glucose homeostasis as a negative regulator of insulin signaling pathway. Objectives: This study aimed to assess the effect of interval training on PTP1B expression in gastrocnemius muscle and insulin resistance in male rats with T2D. Methods: T2D was induced by high fat diet (HFD) and intraperitoneal injection of STZ in 14 male Wistar rats and then they were divided randomly into exercise (n=7) or control (n=7) groups. Exercise rats completed an 8 weeks interval training (5 days/week) and control rats remained without training. Fasting glucose, serum insulin, and PTP1B expression in gastrocnemius muscle were measured 48 hours after the last exercise session. Insulin resistance was assessed using homeostasis model assessment of insulin resistance (HOMA-IR) formula based on fasting insulin and glucose levels. An independent t test was used to compare each parameter between 2 groups. A P value less than 0.05 was considered statistically significant. Results: Interval training resulted in a significant decrease in fasting glucose level (P<0.0001) and insulin resistance (P=0.018) as well as an increase in serum insulin level (P<0.0001). PTP1B expression in gastrocnemius muscle decreased significantly compared with control rats (P=0.003) Conclusion: Interval training can improve insulin resistance in T2D rats. This improvement may be attributed to the decrease in PTP1B expression in gastrocnemius muscle by interval training.
Diabetes and Collagen: Interrelations
Authors: Bondarenko Larysa Borysivna
Published: August 2020

This review summarizes information on interrelations between diabetes development and collagen metabolism and structure. The growing global problem of diabetes requires the search for new strategies of its complications correction. Among them collagen structure violations and/or its impaired metabolism most often lead to profound disability. Even after several decades of intense studies, pathophysiological mechanisms underlying collagen changes in diabetes mellitus are still not well clear. The main complication is that not only diabetes cause changes in collagen metabolism and structure. Collagens via some mechanisms also may regulate glucose homeostasis, both directly and indirectly. The author also presented the results of own studies on bone and skin type I collagen amino acid composition changes with diabetes. Deepening our understanding of collagen metabolism and diabetes interrelations allows us to optimize approaches to overcome the collagen-mediated consequences of this disease. Recently, it has been clearly demonstrated that use of only antidiabetic agents cannot fully correct such violations. Preparations on the base of flavonoids, collagens and amino acids could be considered as perspective directions in this area of drug development.
MicroRNA-155-5p Diminishes in Vitro Ovarian Cancer Cell Viability by Targeting HIF1α Expression
Authors: Ysrafil Ysrafil , Astuti Indwiani , Anwar Sumadi Lukman , Martien Ronny , Sumadi Firasti Agung Nugrahening , Wardhana Tirta , Haryana Sofia Mubarika
Published: August 2020

Purpose
: Ovarian cancer is the most lethal of gynecological malignancies. Recently, the development of microRNA (miRNA) -based therapeutics that could impact broad cellular programs, leading to inhibition of cancer cell viability, is gaining attention in the therapeutic landscape. The therapy is based on the presence of aberrant expressions of miRNA in cancer cells. Decreasing of tumor suppressor miRNA expression causes upregulation of oncoprotein, which worsens the prognosis of the ovarian cancer. Methods: miR-155-5p mimics were carried by chitosan nanoparticles using new nanotechnology methods. Cellular uptake of miRNA was assessed by fluorescence microscope while MTT and qPCR assay were used to determine miRNA profile and the effect of CS-NP/miRNA on SKOV3 cells. Results: Results of profiling validated using quantitative realtime-polymerase chain reaction (PCR) found one of the most altered tumor suppressor miRNAs, miR-155-5p was downregulated 892.15-fold. According to bioinformatic analysis we identified the miRNA could recognize and regulate HIF1α expression. Transfection of mimics for miR-155-5p showed significantly increased miR-155-5p endogen SKOV3 expression level compared to the control group. We found differences after transfection mimics for miR-155-5p 31.5 and 63 nanoMolar. Increasing of miR-155-5p endogen lead to diminished SKOV3 viability (by 30%; <0.05 at concentration 80 nanoMolar). These mimics may cause an increase in upregulated miR-155-5p endogen that can reduce HIF1α expression. Here we found 2-fold and 2.8-fold reduction of HIF1α expression level after transfection compared to the control group. Conclusion: According to these findings, the mimics miR-155-5p can inhibit ovarian cancer cell proliferation by regulating HIF1α expression.
Transcriptome Changes in Colorectal Cancer Cells upon Treatment with Avicequinone B
Authors: Ocampo Yanet , Caro Daneiva , Rivera David , Piermattey Jhoan , Gaitán Ricardo , Franco Luis A.
Published: August 2020

Purpose:
Naphtho[2,3-b]furan-4,9-dione (Avicequinone B), a natural naphthoquinone isolated from the mangrove tree Avicennia alba, is recognized as a valuable synthetic precursor with anti-proliferative effect. However, the molecular mechanism involved in its bioactivity has not been investigated. This study aimed to determine the selectivity of avicequinone B against cancer cells and the transcriptomic changes induced in colorectal cancer (CRC). Methods: The cytotoxic effect against adenocarcinoma-derived cells or fibroblasts was evaluated using MTT assay. In addition, CRC cells were treated with avicequinone B in different settings to evaluate colony-forming ability, cell cycle progression, apoptosis/necrosis induction, and transcriptome response by RNA-seq. Results: Avicequinone B effectively reduced the viability of breast, colorectal, and lung adenocarcinoma cells with IC50 lower than 10 μM, while fibroblasts were less affected. The induction of G2/M arrest and necrosis-like cell death were observed in avicequinone B-treated HT-29 cells. Furthermore, RNA-seq revealed 490 differentially expressed genes, highlighting the reduction of interferon stimulated genes and proliferative signaling pathways (JAK-STAT, MAPK, and PI3K-AKT), as well as the induction of ferroptosis and miR-21 expression. Conclusion: In short, these results demonstrated the therapeutic potential of avicequinone B and paved the foundation for elucidating its mechanisms in the context of CRC.
PENGARUH CORPORATE SOCIAL RESPONSIBILITY DAN CITRA PERUSAHAAN TERHADAP LOYALITAS PELANGGAN PT ABC PRESIDENT INDONESIA
Authors: Saragih, MM. Bongsu
Published: August 2020

The purpose of this study was to determine the effect of corporate social responsibility and corporate image on customer loyalty in the company PT ABC President Indonesia. The research method used is quantitative research and explains each variable used. The population and sample in this study are customers who incidentally were taken when shopping for 100 respondents. The results of the research analysis say that corporate social responsibility and corporate image simultaneously have a positive effect on customer loyalty.
PERBANDINGAN PREDIKSI KEBANGKRUTAN MENGGUNAKAN MODEL ALTMAN MODIFIKASI, SPRINGATE, ZMIJEWSKI DAN GROVER PT RATU PRABU ENERGI TBK
Authors: Suparningsih Budhi , Chaeriah Ella Siti
Published: August 2020

This study examines comparative analysis to predict bankruptcy using the modified Altman, Springate, Zmijewski and Grover models at PT. Ratu Prabu Energi, Tbk. which is engaged in the mining sector. This study aims to predict bankruptcy at PT. Ratu Prabu Energi, Tbk. and to evaluate whether the predictions match the actual conditions of the company. The type of research applied is a case study at PT. Ratu Prabu Energi, Tbk. during 2009 until 2018. Data were analyzed using qualitative descriptive analysis techniques. The results of the analysis of the four bankruptcy models have different results, although there are some in the position of the Safe Zone but the value is very small and almost close to the Distress Zone, so the company seems to have unfavorable financial conditions as indicated by the low weighting value of the four bankruptcy models . From the beginning this condition has been seen from the ratios represented in each bankruptcy model. Of the four bankruptcy models, this gives a fairly high value deviation in the Altman Z-Score Modification model rather than using the Springate, Zmijewski and Grofer bankruptcy models.
PENGARUH IMPLEMENTASI TRISILA TNI AL TERHADAP SEMANGAT PENGABDIAN PRAJURIT PANGKALAN TNI AL
Authors: Kurniawan Eko Arie , Sudardi Sudardi
Published: August 2020

Trisila TNI AL is a guidance for every naval soldiers as codes of conduct to perform in their office and their environment. The implementation of this codes of conduct is required to keep and enhance the spirit and dedication of the "A" naval  base's personnel in order to keep up  with the new status as a main naval base. The aim of the journal is to analyze the influence of the Trisila TNI AL's implementation as firstorder and its influences on the soldiers' spirit and dedication as second order. This journal based on research to 75 respondents of the total population 297 soldiers in "A" naval base. This questionnaire in which is qualitative method mixed with the quantitative method that utilize the linear regression analysis. The result of this research shows that there are positive influences and significant effects of the implementation of trisila TNI AL, wheter as partial variables or simultaneous variables.
PENGARUH DUKUNGAN PEMBEKALAN PANGKALAN TNI ANGKATAN LAUT TERHADAP OPERASI PENGAMANAN PERBATASAN
Authors: Rusmaji Constantius , Suhardono Edi
Published: August 2020

This study explains the support variables for Naval Base supplies for border security operations. The research method used is a quantitative method by distributing questionnaire.The number of samples taken was 80 samples from the total population of 371 persons. The research was carried out starting from the classification of samples respondents based on gender, age, education and years of service. The research variables in this study are supporting variables in the supply as independent variables (X) and border security operations variables as cooperation variables (Y). Indicators for variable X include: personnel involved in the supply, infrastructure for the supply of equipment, supporting facilities for the supplies and types of supplies that can be supported. While indicators on the Y variables include: personnel involved in the operation, operating facilities, area of operation and duration of operation. The data analysis process is carried out with several tests, among others: validity test, namely testing the data analysis process to determine whether the research instrument is valid or not. The next test is the reliability test, the data analysis process to answer the accuracy of the research instruments. The normality of the trial is tested. The next data analysis process is the hypothesis test in the regression test. Regression test is a process of analyzing data to study the influence between research variables. The regression test conducted in this study is a partial regression test because the independent variable used is one variable. After it was implemented, everything was proven. Supports provisioning variables. Naval Base determines positive and significant impact on border security operations.
KINERJA PORTOFOLIO DENGAN METODE SHARP, JENSEN DAN TREYNOR PADA SAHAM INDUSTRI TEKSTIL DI BURSA EFEK INDONESIA
Authors: Sodiqin, SE., MM. Dr. Ahmad
Published: August 2020

This study aims to determine portfolio performance using the methods of Sharp, Jensen and Treynor. The companies involved in this study were 18 companies in the industry group of textile which were listed on the Indonesia Stock Exchange in 2016. Data were taken monthly for 12 months. The data is then analyzed to determine the elements needed in the analysis namely market profits, standard deviation of profits (total risk), beta (systematic risk) and risk free profits (risk free).  Based on data analysis, it is known that portfolio performance is calculated using 3 methods, namely Sharp, Treynor and Jensen methods in the textile industry stock which includes 18 companies which are mostly negative. However, if it is classified according to non-negative values, then the performance according to the Treynor and Jensen methods can be used as a reference because all of the items that are compared have positive values.  According to the Treynor Index shares that can be used as a reference for entry in investments are CNTB, CNTX, ERTX, HDTX and ARGO shares. Meanwhile, according to Jensen's index of shares that can be included in the investment are SSTM, STAR, MYTX and POLY.
PENGARUH CITRA MEREK DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN MOBIL HONDA JAZZ
Authors: Sudrajat, SE., MM. Ajat , Nuraini Nuraini , Hamidi Muhammad Jazim
Published: August 2020

The purpose of this study to obtain the empirical evidence and to find clarity of phenomena and conclusions about the influence of these two variables above on Car Buying Honda Jazz Decision to consumers Honda Jazz in Karawang. Samples were collected by using Purposive Sampling with a sample of 100 respondents. Data analysis techniques used are Scale Range Analysis and Path Analysis with the help of Method of Successive Interval (MSI), Microsoft Excel 2010 and SPSS 21 computer programs. From the analysis of research data, obtained some conclusions are follows: Honda Jazz Car Image of 393.6 is on criteria Agreed. Quality of Honda Jazz Car Product of 382.2 is on criteria Agreed. Car Buying Honda Jazz decision of 398.53 is on criteria Agreed. There is a partial influence between Brand Image and Product Quality of 0.651. This shows a strong and undirectional relationship because it has a positive value. There is partial influence between Brand Image to Purchase Decision equal to 38.3% and there is partial influence between Product Quality to Purchase Decision equal to 47.3%. There is simultaneous influence between Brand Image and Product Quality on Car Buying Decision of Honda Jazz to consumers in Karawang equal to 60.3%, while the rest are other factors not examined equal to 39.7%.
PENGARUH PENGEMBANGAN KARIR DAN MOTIVASI KERJA TERHADAP KINERJA KARYAWAN PT. WISC INDONESIA
Authors: Islamiati Annisa , Razak Ismail , Susanto Putri Herlaines
Published: August 2020

The purpose of this study is to analyze the effect of career development and work motivation on the performance of employees of PT. WISC Indonesia. The data used are primary data through questionnaires to employees of PT. WISC Indonesia as respondent. The analytical method used is a simple and multiple linear regression analysis. The results indicated that career development and work motivation had a positive and significant effect on the performance of employees of PT. WISC Indonesia.
PENGARUH KEPERCAYAAN, KEAMANAN DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN
Authors: Mutiara Mutiara , Wibowo Imam
Published: August 2020

This research analyzes ecommerce on online purchasing decisions. The purpose of this study was to determine the influence of trust, safety, product quality on online purchasing decisions at shopee. The total population used was 1,200 taken from researchers' instagram followers and the number of samples used in this study were 92 respondents. This research is a quantitative study, using simple linear regression analysis and multiple linear regression. The results of this study were obtained simultaneously showing the positive influence of product safety and quality while trust has a negative influence on purchasing decisions. Partially, there is a positive and significant influence of trust, safety and product quality on purchasing decisions. And there is advice given, that shopee companies need to pay attention to consumer confidence and develop the quality of products that are needed and desired by consumers in shopping online.
PENGARUH KEPUASAAN KERJA DAN LOYALITAS KERJA TERHADAP KINERJA KARYAWAN PT BANK SAHABAT SAMPOERNA JAKARTA
Authors: Subagja, SE., MM. Iwan Kurniawan , Safrianto Arief Syah
Published: August 2020

This study aims to analyze 1) the effect of job satisfaction on employee performance at PT Bank Sahabat Sampoerna KCP Kelapa Gading, 2) the effect of work loyalty on employee performance at PT Bank Sahabat Sampoerna KCP Kelapa Gading, 3) the effect of job satisfaction and job loyalty towards employee performance at PT Bank Sahabat Sampoerna KCP Kelapa Gading. The data used in this study are primary data with a research instrument in the form of a questionnaire. The population in this study were employees at PT Bank Sahabat Sampoerna KCP Kelapa Gading. The sample is 48 respondents. The saturated sampling technique and the analytical tool used in this study is simple and multiple linear regression. The results showed: 1) job satisfaction affected the performance of employees at PT Bank Sahabat Sampoerna KCP Kelapa Gading, 2) work loyalty affected the performance of employees at PT Bank Sahabat Sampoerna KCP Kelapa Gading, 3) job satisfaction and work loyalty affected the performance of employees at PT Bank Sahabat Sampoerna KCP Kelapa Gading.
Konservasi Air Di Provinsi Kalimantan Utara (Studi Potensi Embung Di Kabupaten Bulungan)
Authors: Harviyanti Enny , Abidin Zainal , Nofrizal
Published: August 2020

Tujuan studi ini untuk menginventarisasi sungai-sungai yang potensial dijadikan lokasi embung untuk memenuhi kebutuhan air penduduk di sekitarnya dan mengetahui debit yang tersedia pada sungai tersebut. Metodologi yang digunakan adalah pengumpulan data dari instansi terkait, survai lapangan, pemilhan lokasi embung dan analisis kebutuhan & ketersediaan air di sungai. Berdasarkan kriteria pemilihan lokasi embung dengan ketigaaspek, nilai modifikasi bobot pertimbangan dan pertimbangan salah satu aspek saja maka disimpulkan nilai lokasi yang tertinggi adalah Embung Tanjung Palas. Neraca air Embung Tanjung Palas menunjukkan bagaimana kriteria dari aspek teknis dan non teknis memiliki rangking tertinggi.
Barriers to Diffusion in Cells: Visualization of Membraneless Particles in the Nucleus
Authors: Malacrida Leonel , Hedde Per Niklas , Torrado Belen , Gratton Enrico
Published: August 2020

Transient barriers are fundamental to cell supramolecular organization and assembly. Discontinuities between spaces can be generated by a physical barrier but also by thermodynamic barriers achieved by phase separation of molecules. However, because of the transient nature and the lack of a visible barrier, the existence of phase separation is difficult to demonstrate experimentally. We describe an approach based on the 2-dimensional pair correlation function (2D-pCF) analysis of the spatial connectivity in a cell. The educational aim of the article is to present both a model suitable for explaining diffusion barrier measurements to a broad range of courses and examples of biological situations. If there are no barriers to diffusion, particles could diffuse equally in all directions. In this situation the pair correlation function introduced in this article is independent of the direction and is uniform in all directions. However, in the presence of obstacles, the shape of the 2D-pCF is distorted to reflect how the obstacle position and orientation change the flow of molecules. In the example shown in this article, measurements of diffusion of enhanced green fluorescent protein moving in live cells show the lack of connectivity at the nucleolus surface for shorter distances. We also observe a gradual increase in the connectivity for longer distances or times, presumably because of molecular trajectories around the nucleolus.