bluuebunny/crossref_metadata_2025 huggingface dataset:
PLATELETS FUNCTIONS, ORGANIZATION, AND THEIR ASSOCIATED DISEASES: A BRIEF REVIEW
Authors: Agarwal Dr. Arpit
Published: January 2024

In healthy hemostasis and pathological states like thrombosis, inflammation, and cancer, platelets a varied small nucleate blood cell types play a crucial role. New, vital information regarding platelet biology and platelet responses to different pathogenic pathways has been provided by recent advances in proteomic studies. Given their ubiquitous distribution and relative ease of isolation from human samples, platelets provide a prime candidate for proteomic analysis, which holds great promise for unraveling the intricate roles played by platelets in health and illness, identifying and evaluating prospective protein molecules derived from platelets as biomarkers, and developing new antiplatelet therapeutic targets. This review provides up-to-date information on platelet organization, platelet-related disorders, stimulation heterogeneity and its effects on diverse platelet functions, and numerous therapeutic targeting efforts involving platelets.
INTRICACIES OF VAGINAL MICROBIOME IN HUMAN FEMALE HEALTH: A LITERATURE REVIEW
Authors: Wasim Dr. Saeeda
Published: January 2024

The vaginal microbiome profoundly impacts women's reproductive health. This review examines its significance, exploring microbial diversity, imbalances, infections, and preventive strategies. Imbalances, triggered by various factors, lead to infections such as bacterial vaginosis, yeast infections, and urinary tract infections. Research into personalized interventions, including probiotics tailored to individual microbial compositions, shows promise. Novel therapeutics targeting dysbiosis and disease prevention strategies, alongside technological advancements in diagnostics, highlight the future of healthcare. Understanding microbiome-associated reproductive outcomes and identifying microbial biomarkers for diseases beyond infections are emerging frontiers. Integrating findings into clinical practice and public education enhances vaginal health practices. This comprehensive overview underscores the need for continued research to develop precise interventions supporting a balanced vaginal microbiome and enhancing women's reproductive well-being. The evolving understanding of the vaginal microbiome holds vast potential to revolutionize healthcare, aiming for personalized, preventive, and effective interventions.
NEUROENDOCRINE TUMOR PRESENTING AS PERITONEAL MASSDIAGNOSTIC DILEMMA
Authors: Tandon Dr. Nishi
Published: January 2024

Neuroendocrine tumours (NET) are found to be aggressive and extremely rare tumour. Its annual incidence is approximately 2.5-5.0 per 100,000. NET which are arise from cells of the nervous and endocrine systems. Majority of NET are seen within the GIT(55%) and respiratory system(30%). Most common site are mainly 45% of small intestine,followed by 20% of rectum , 17% of appendix, 11% of colon and then 7% of stomach. Cancer of this type is highly aggressive, and can occur in younger patients.MRI – the best method to achieve because it provides precise information and clear images regarding their location, size and complexity of mass. Small cell NET is associated with thier early metastases to lymph nodes and liver and poor prognosis. Treatment for localized small cell NE carcinoma are done by mainly postoperative chemotherapy or radiation therapy with surgical excision. This type of tumor are characterized or identified by their aggressive behavior, natural history and often have widespread metastatic nature on presentation.
OBSTETRIC CHOLESTASIS IN FIRST TRIMESTER-UNUSUAL PRESENTATION OF THE DISEASE: CASE REPORT
Authors: Nishad Dr. Suman
Published: January 2024

Obstetric cholestasis (OC) presents mainly in the third trimester and uncommonly in the second trimester of pregnancy. It is characterised by pruritus, abnormal liver enzymes and raised total serum bile acids (TSBA). Cholestasis resolves after delivery. OC presenting in first trimester is rare, therefore the management guidelines are unclear. The present case is being reported as a case of first trimester OC, unresponsive to common treatment modalities. The patient was diagnosed with OC at 12 weeks. She didn't respond to the therapeutic doses of ursodeoxycholic acid (UDCA) and cholestyramine. Finally, rifampicin was added, which gave clinical relief, improved liver enzyme levels and allowed the pregnancy to continue till 32 weeks.
Preparation of a recombinant ribonuclease inhibitor in E. coli for use in mRNA synthesis in vitro
Authors: Zakharova MV , Zagoskin AA , Ivanov RA , Nagornykh MO
Published: January 2024

Technologies underlying the production of synthetic mRNAs in vitro have significantly expanded the possibilities for research and therapeutic use of this class of molecules. The flagship application area has been the niche of mRNA vaccines, but this class of therapeutic molecules has the potential to be applied in a much broader range of situations. The process of in vitro production of artificial RNA molecules is based on an enzymatic synthesis reaction, one of the components of which is a ribonuclease inhibitor. This protein protects synthesized RNA from attacks by ribonucleases and prevents degradation of the molecules, which is critically important for RNA. Eukaryotic ribonuclease inhibitor synthesized as a recombinant protein in the cells of E. coli bacteria is the most common choice. However, the structure of this protein makes it a difficult product to make in bacteria. This study aimed to test the production of a recombinant ribonuclease inhibitor in various strains of E. coli, and to show the effect that helper polypeptides and cellular chaperones have on this process. Using genetic engineering approaches, we constructed plasmids, from which chimeric ribonuclease inhibitor molecules and helper polypeptides were produced. The influence of various components on solubility of the target recombinant protein was assessed with the help of densitometry, to which we have subjected products of the PAGE electrophoresis. It was determined that combinations of a vector with a strong promoter for the expression of the RNH1 ribonuclease inhibitor gene and helper polypeptides MBP and TIG against the background of increased expression of cellular chaperones dnaK, dnaJ, grpE give the target product yield of 45 mg/l and 60 mg/l, respectively. The selected conditions allow large-scale production of this protein for further use in in vitro RNA synthesis in the context of production of medicines.
Tekhnologiya mikrohirurgicheskoj rekonstrukcii fovea pri makulyarnyh razryvah
Authors: Тахчиди Х. П.
Published: January 2024

Odnoj iz vedushchih vitreoretinal'nyh patologij, privodyashchih k znachitel'nomu uhudsheniyu zritel'nyh funkcij, yavlyaetsya makulyarnyj razryv. V poslednie gody v hirurgii makulyarnyh razryvov perspektivno ispol'zovanie autoplazmy krovi s povyshennym soderzhaniem trombocitov. No, nesmotrya na vysokij procent zakrytiya makulyarnyh razryvov (78–96%), na segodnyashnij den' aktual'nym voprosom ostaetsya razrabotka novyh tekhnologij, napravlennyh na vosstanovlenie mikroarhitektoniki foveolyarnoj oblasti i povysheniya zritel'nyh funkcij. Cel'yu issledovaniya bylo razrabotat' novuyu tekhnologiyu rekonstrukcii foveolyarnoj oblasti pri makulyarnyh razryvah s ispol'zovaniem autologichnoj kondicionirovannoj plazmy. V predstavlennuyu rabotu voshli 9 pacientov (10 glaz) s idiopaticheskim skvoznym makulyarnym razryvom, kotorym byla vypolnena standartnaya trekhportovaya 27G-vitrektomiya s primeneniem autologichnoj kondicionirovannoj plazmy po razrabotannoj tekhnologii. V rezul'tate hirurgicheskogo lecheniya predlagaemaya tekhnologiya pozvolyaet poluchit' vysokie kliniko-funkcional'nye rezul'taty, a takzhe obespechivaet optimal'nuyu i bolee upravlyaemuyu rekonstrukciyu mikroarhitektoniku fovea.
Exploration de l’association entre la proximité et la densité des détaillants de produits IQOS autour des écoles et l’utilisation de produits de tabac chauffé chez les adolescents : données de l’étude COMPASS 2020-2021
Authors: Mott Hunter , Leatherdale Scott T. , Cole Adam G.
Published: January 2024

Introduction

Les produits de tabac chauffé sont de nouveaux produits du tabac susceptibles d’attirer les jeunes. Cette étude visait à explorer, dans quatre provinces canadiennes, si la proximité et la densité des détaillants de produits de tabac chauffé autour des écoles secondaires étaient associées à une utilisation de ces produits chez les adolescents.

Méthodologie

Une recherche menée en ligne entre novembre 2020 et mars 2021 a permis de repérer les détaillants qui vendaient des dispositifs IQOS et des bâtonnets HEETS (conçus pour les dispositifs IQOS) dans des zones tampons circulaires de 500 m, 1 000 m et 1 500 m autour de 120 écoles secondaires ayant participé à l’étude COMPASS 2020-2021. Les données sur la proximité et la densité des détaillants ont été liées à des données transversales sur les élèves (N = 40 636), et des modèles de régression multiniveaux ont été utilisés pour explorer l’association entre, d’une part, la proximité et la densité des détaillants de produits de tabac chauffé et, d’autre part, l’utilisation de produits de tabac chauffé, après ajustement pour les covariables pertinentes.

Résultats

Si seulement 10,0 % des écoles étaient situées à moins de 1 000 m d’au moins un détaillant vendant des dispositifs IQOS, 65,0 % d’entre elles étaient situées à proximité d’au moins un détaillant vendant des bâtonnets HEETS. L’école fréquentée par l’élève était responsable de 23,7 % de la variabilité de la probabilité d’utilisation de produits de tabac chauffé. Toutefois, la proximité et la densité des détaillants de produits de tabac chauffé autour des écoles n’ont présenté aucune association significative avec la probabilité d’utilisation de ces produits chez les élèves.

Conclusion

Bien que l’école fréquentée par l’élève soit responsable d’une part importante de la variabilité de l’utilisation de produits de tabac chauffé, ces résultats laissent penser que les élèves pourraient obtenir des produits de tabac chauffé par des sources autres que les commerces de détail. Il faut continuer de surveiller la situation, car l’utilisation des produits de tabac chauffé chez les adolescents est susceptible d’évoluer.
Obstacles en matière de soins de santé et santé mentale perçue chez les adultes au Canada pendant la pandémie de COVID-19 : étude transversale fondée sur la population
Authors: Shiraz Mehrunnisa , Capaldi Colin A. , Ooi Laura L. , Roberts Karen C.
Published: January 2024

Introduction

La santé mentale perçue des personnes au Canada ayant rencontré des obstacles en matière de soins de santé pendant la pandémie de COVID-19 est sous-explorée.

Méthodologie

Nous avons analysé les données collectées entre mars et juin 2021 sur les adultes ayant déclaré avoir eu besoin de services de santé au cours des 12 derniers mois dans le cadre de l’Enquête sur l’accès aux soins de santé et aux produits pharmaceutiques pendant la pandémie. Des analyses de régression logistique non ajustées et ajustées ont été menées pour explorer les associations entre les obstacles en matière de soins de santé (problèmes liés à la prise de rendez-vous, report de la communication avec un professionnel de la santé) et un niveau élevé de santé mentale autoévaluée ainsi que la perception d’une détérioration de la santé mentale par rapport à la période précédant la pandémie, de façon globale et avec stratification en fonction du sexe, du groupe d’âge, du nombre de problèmes de santé chroniques et du tertile de revenu du ménage.

Résultats

Les personnes ayant subi des changements de rendez-vous en raison de la pandémie ou dont le rendez-vous n’avait pas encore été fixé étaient moins susceptibles d’avoir un niveau élevé de santé mentale autoévaluée (RCa = 0,81 et 0,64 respectivement) et plus susceptibles de percevoir une détérioration de leur santé mentale (RCa = 1,50 et 1,94 respectivement) que les personnes sans problème lié aux rendez-vous. Les personnes ayant tardé à communiquer avec un professionnel de la santé en raison de la pandémie (par exemple parce qu’elles craignaient d’être infectées) ou pour d’autres raisons étaient moins susceptibles d’avoir un niveau élevé de santé mentale autoévaluée (RCa = 0,52 et 0,45 respectivement) et plus susceptibles de percevoir une détérioration de leur santé mentale (RCa = 2,31 et 2,43 respectivement) que les personnes qui n’avaient pas tardé à communiquer avec un professionnel de la santé. Le report de la communication avec un professionnel de la santé pour des raisons liées à la pandémie était associé à une perception moins favorable de la santé mentale dans tous les sousgroupes, tandis que l’association entre la santé mentale perçue et les changements de rendez-vous liés à la pandémie était importante dans certains groupes seulement.

Conclusion

Les obstacles en matière de soins de santé pendant la pandémie ont été associés à une perception moins favorable de la santé mentale. Ces résultats pourraient orienter l’affectation des ressources en soins de santé et les messages de santé publique.
Luggage The Luggage Product Design with Electric Drive Concept
Authors: Adrianto Yosef
Published: January 2024

Pro D.I.Y is a combination of Pro (professional) and Do It Yourself (modify or make things yourself) to carry clothes, laptops, skincare, or other loads practically and efficiently. This product will be aimed at influencers/celebs who complain about carrying work items simultaneously but using various sizes of bags. This makes the celebgrams need a personal assistant to help carry the bags. This Portable Bag uses the concept of electric drive which is more efficient to use luggage electrically. This product uses materials that have waterproof properties when exposed to water spills including synthetic leather, aluminum, and parachute cloth. In addition to focusing on the functional side, researchers also focus on design and aesthetic models, to support this, researchers will conduct several data collection techniques so that the resulting product is maximized.
Potensi Penggunaan Selulosa Kelapa Sawit Sebagai Bahan Sneakers
Authors: Wiguna Sherrine
Published: January 2024

The solution to the problem of environmental sustainability is increasingly urgent due to the growing number of consumers which is exacerbated by the use of raw materials for the manufacture of products that are not environmentally friendly. Therefore, the demand for environmentally friendly products or bioproducts has recently become increasingly popular and has become a challenge for manufacturers to increase production and innovation, especially in the footwear sector. One of the innovations that can be used to support the bioproduct mission is the use of material fiber derived from plant waste in the form of cellulose from empty palm oil bunches which has characteristics resembling synthetic leather. The research is supported by the results of a literature study that has been carried out as well as observations in the form of experiments testing several upper materials for resistance and moisture to testing cellulose materials in the sneaker product section. The experimental results show that cellulose materials can support the application of several anatomical parts of upper sneakers with supports in the form of a combination of materials such as cowhide, synthetic materials and corduroy fabrics as supports for cellulose materials. The results of the research are expected to raise awareness among users about the use of sustainable and recyclable materials that can be applied to fashion styles that can compete with non-bioproducts.
EFEKTIFITAS PERATURAN DAERAH KOTA PALU NOMOR 6 TAHUN 2012 TENTANG PENERTIBAN TERNAK
Authors: Muhajir  , M. Taufan B  , Besse Tenriabeng Mursyid
Published: January 2024

Regional Regulations (Perda) are the main pillar that covers the realization of regional autonomy. The existence of Palu City Regional Regulation Number 6 of 2012 concerning Livestock Control does not make Palu City more orderly because, in fact, livestock such as cows and goats can be found roaming freely on the streets of Palu City, especially in West Palu District. This problem makes transroad users anxious, especially two-wheelers and the local community. This research starts with the problem, namely, how effective Palu City Regional Regulation Number 6 of 2012 concerning livestock control is, and what are the factors that influence the effectiveness of Palu City Regional Regulation Number 6 of 2012 concerning livestock control? The approach used in this research is an interdisciplinary approach, which is an approach to solving a problem by using a review of various points of view. In this research, empirical legal research is used, a research method that reviews the function of a law or rule in terms of its application within the scope of society. This research method is also called sociological legal research. The results of the research show that there are several factors that are weaknesses in the Regional Regulations regarding the control of livestock animals, namely, 1) lack of public awareness 2) lack of government outreach 3) lack of supervision and firmness 4) inadequate facilities and infrastructure, and 5) community culture.

Abstrak

Peraturan Daerah (Perda) merupakan pilar utama yang memayungi realisasi otonomi daerah. Keberadaan Peraturan Daerah Kota Palu Nomor 6 tahun 2012 tentang Penertiban Ternak tidak menjadikan Kota Palu menjadi lebih tertib karena pada faktannya hewan ternak seperti sapi, dan kambing dapat dijumpai bebas berkeliaran dijalan Kota Palu, khususnya di Kecamatan Palu Barat. Persoalan tersebut membuat resah para pengguna jalan trans, khususnya roda dua dan masyarakat setempat. Penelitian ini berangkat dari masalah yaitu, Bagaimanakah Efektivitas Peraturan Daerah Kota Palu Nomor 6 Tahun 2012 tentang Penertiban Ternak dan Apakah Faktor yang Memengaruhi Efektivitas Peraturan Daerah Kota Palu Nomor 6 Tahun 2012 tentang Penertiban Ternak. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan interdisipliner, (interdisciplinary approach) ialah pendekatan dalam pemecahan suatu masalah dengan menggunakan tinjauan berbagai sudut pandang. Pada penelitian ini menggunakan penelitian hukum empiris adalah metode penelitian yang meninjau fungsi dari suatu hukum atau aturan dalam hal penerapannya di ruang lingkup masyarakat. Metode penelitian ini disebut juga dengan penelitian hukum sosiologis. Hasil penelitian yang menunjukan bahwa terdapat beberapa faktor-faktor yang menjadi kelemahan dalam Peraturan Daerah tentang penertiban hewan ternak tersebut yaitu, 1) kurangnnya kesadaran masyarakat 2) kurangnnya sosialisasi pemerintah 3) tidak adannya pengawasan dan ketegasaan 4) sarana dan prasarana yang tidak memedai serta 5) budaya masyarakat.
La literatura de no ficción en México: Asesinato, de Vicente Leñero
Authors:   , Allende Ortega Jesús Iván
Published: January 2024

Abordar el tema de literatura de no ficción resulta relevante tanto para el estudio de la literatura como para el del periodismo, ya que es dentro de estas dos áreas donde este género encuentra sus fronteras. Existen diversos artículos e investigaciones que se han encargado de estudiar el tema, en la mayoría de los casos estos estudios parten de las obras fundacionales de la no ficción. Entre ellas se encuentran: Operación Masacre (1957) de Rodolfo Walsh, A sangre fría (1966) de Truman Capote y Los ejércitos de la noche (1968) de Norman Mailer. Sin embargo, son pocas las investigaciones que se han encargado del estudió de la no ficción en México, su surgimiento y obras fundacionales. Por este motivo, en la siguiente investigación se analizará el cuarto capítulo de la novela Asesinato (1985) del escritor Vicente Leñero. En esta novela es donde se pueden observar con mayor claridad los elementos propios de la no ficción, así como el estilo dado por Leñero a este género. Elementos que lo vuelven uno de los fundadores de este género en la narrativa mexicana del siglo XX. Para sustentar teóricamente el análisis de este texto se retomarán las ideas expuestas por Tom Wolf y Jonh Hollowell, respecto al tema del llamado “Nuevo periodismo” o Literatura de no ficción. Finalmente, para entender el término “nuevo periodismo” en la narrativa mexicana es necesario revisar de forma general la evolución del periodismo en México, ya que éste sentó las bases para la creación de la no ficción. Son las técnicas de representación de la no ficción las que permiten observar la evolución del periodismo. La información ya no está delimitada a la transmisión llana del hecho. Ahora la voz de los sujetos implicados, así como la del periodista son tan importantes como la acción misma. Lo imparcial adquiere un tono personal.
Vivir en el exilio entre trompetas y mariachis: La Ciudad de México como espacio de (re)encuentro en Mis voces cantando de Antonio Marimón
Authors:   , Salazar Ortiz David
Published: January 2024

La palabra “exilio” tiene su origen en el verbo latino exsilere, cuyo significado engloba tanto el acto de salir de un lugar como de abandonar un espacio por otro. Hoy en día, este término alude al destierro de una persona o grupo a causa de la violencia. Voluntaria e involuntariamente el exilio quebranta el espíritu de los sujetos; los despoja de su familia, de la escuela, así como de los centros de trabajo. Durante los años setenta, casi todos los países de América Latina estuvieron sumergidos en dictaduras militares. En todos los casos los gobiernos de facto crearon un sistema “político” basado en la represión y el terror estatal. El modus operandi consistía en la desaparición forzada de opositores al régimen, allanamiento de morada, secuestro y tortura. Países como Argentina, Uruguay y Chile son un ejemplo claro de la brutalidad ejercida por el Estado opresor. Un gran número de latinoamericanos encontraron asilo político en México. Para algunos fue sólo un lugar de paso; para otros se convirtió en su hogar permanente. Un claro ejemplo de ello lo podemos encontrar en la figura de Antonio Marimón, escritor y periodista exiliado en México durante la década de los sesenta. El objetivo principal de este trabajo consiste en analizar los elementos narrativos que permiten restituir la identidad escondida del autor dentro de la novela Mis voces cantando. Por medio de un interesante ejercicio memorístico desplegado en el personaje de Rubén Muñiz — alter ego de Antonio Marimón —, el “yo” autorial recupera fragmentos de su vida antes, durante y después del exilio. Apoyado de diferentes géneros textuales y formas discursivas, verbaliza la experiencia de vivir despojado de su patria y de su lengua.
Driving the future: Leveraging digital transformation for sustainable transportation
Authors: Alanazi Fayez , Alenezi Mamdouh
Published: January 2024

The transportation sector is currently experiencing a significant transformation due to the influence of digital technologies, which are revolutionizing travel, goods transportation, and interactions with transportation systems. This study delves into the possibilities and obstacles presented by digital transformation in the realm of sustainable transportation. Moreover, it identifies the most effective methods for implementing digital transformation in this sector. Furthermore, our analysis sheds light on the potential impacts of digital transformation on sustainable development and environmental performance indicators within transportation systems. We discover that digital transformation can contribute to reduced greenhouse gas emissions, improved air quality, and increased resource efficiency, among other benefits. Nevertheless, we emphasize the potential risks and uncertainties associated with digital transformation, including concerns regarding data privacy, security, and ethics. Collectively, our research provides valuable insights into the opportunities and challenges presented by digital transformation in sustainable transportation. It also identifies best practices for successfully implementing digital transformation in this sector. The implications of our findings are significant for policymakers, businesses, and other stakeholders who aspire to drive the future of sustainable transportation through digital transformation.
Una amabilidad incómoda
Authors: Delos Dela
Published: January 2024

25 de enero - 22 de febrero 2018 Sala de exposiciones de la Facultad de Bellas Artes de Málaga
The Force Requirements for Tooth Movement Part II: Uprighting and Root Torque
Authors: Lee Brian W.
Published: January 2024

In orthodontic treatment tooth root movement is essential, not only to ohtain mesio-distal paralleling of individual tooth roots, but also to achieve correct axial inclinations in relation to hasal bones and inter-incisal angles in the anterior segments. This article describes a pilot study in which paired teeth on opposite sides of the mouth and which required root paralleling as a part of orthodontic treatment, were subjected to known, moments of force. The forces were exerted using helical torsion springs of predetermined load-deflection characteristics. Average weekly moments of force were related to the weekly rates of angular movement of eight teeth in a group of four patients. The experiments lasted for up to seven weeks and were designed so that the movement of the paired teeth in each patient were concurrent.
PERANCANGAN SOLAR IRRIGATION PUMP DENGAN SISTEM SOLAR TRACKER DI SUBAK MALIKODA
Authors: Windradharama W. A.A. G. Guna , Satya Kumara I Nyoman , Setiawan I Nyoman
Published: January 2024

Water is a fundamental necessity for agricultural land and can be obtained from various sources depending on its geographical location. The Keliki Village Farmers Group in Subak Malikoda faces the challenge of drought, leading to a shortage of water supply during the dry season. In this research, the Solar Irrigation Pump (SIP) is designed with a solar tracker system to pump groundwater with the aim of enhancing irrigation water supply for Subak Malikoda during the dry season. The design of the solar-powered irrigation pump system consists of an 18.5 kW submersible pump coupled with a 23.1 kWp PV system using 60 monocrystalline solar modules equipped with a solar tracker and utilizing a 30 kW inverter. Based on the conducted analysis, the PVSyst results show that the SIP without a solar tracker can operate for 6,067 hours with an average water discharge of 274.9 m3/day, based on the received global effective irradiation of 1765.1 kWh/m2 in one year. However, with the use of the solar tracker system, the pump can operate for 6,933 hours with a water discharge of 305.2 m3/day and global effective irradiation of 1963.8 kWh/m2 in one year. The results of the analysis conclude that the SIP with a solar tracker system is capable of operating optimally and meeting the water discharge requirements of Subak Malikoda. This positions the solar tracker system as an effective solution in enhancing the water supply for Subak Malikoda during the dry season.
ANALISIS RE-SETTING DISTANCE RELAY MENGGUNAKAN METODE ARTIFICIAL NEURAL NETWORK PADA SALURAN TRANSMISI SISTEM 150 KV GARDU INDUK BANGIL – GARDU INDUK PIER
Authors: Adi Prasetyo Wibisono , Karim Mewal Karel A , Sianturi Roni , Mataram I Made , Indra Partha Cok. Gede
Published: January 2024

The results of conducting impedance measurements at the Bangil - PIER Substation using the Omicron CPC100 tool show the difference in the results with the factory specification impedance value which exceeds the tolerance limit of 5% of the test results. Re-setting the distance relay is needed so that the relay is able to properly secure the transmission line. In this study, the Artificial Neural Network model was used to re-setting the distance relay. Re-setting was carried out using Analysis Software Based on Modeling and Visualization showed that the relay worked very well in responding to disturbances without overlapping it ranges. The results of calculation using ANN showing a very high level of accuracy of 99.88% and an error rate of 0.00113. Other data analysis indicators used produce the following values: MSE = 0,00002, RMSE = 0,0047 , MAD = 0,00361 , and MAPE = 0,163% which indicates that the Neural Network model that has been made is feasible to use.
SIMULASI INTERKONEKSI PLTS APUNG DI DANAU BATUR DENGAN PENYULANG KINTAMANI
Authors: Jaya Kusuma I Kadek Bagus , Satya Kumara I Nyoman , Setiawan I Nyoman
Published: January 2024

Lake Batur has the potential to build a floating solar power plant to improve voltage drop disturbances. The author uses three scenarios using power flow analysis and transient analysis for each scenario in Kintamani. Scenario 1 with a floating solar power plant capacity of 10 MW has a positive impact by increasing the busbar voltage value but there are reverse power conditions that can disrupt the power system at the Payangan Substation. Scenario 2 with a floating PLTS capacity of 1.2 MW has a positive impact by increasing the voltage value and does not cause reverse power at Payangan Substation. Scenario 3 with a floating PLTS capacity of 3 MW has a positive impact by being able to increase the voltage value and does not result in reverse power at Payangan GI. When the floating solar power plant loses power production, it causes a decrease in voltage value, then the system stabilizes again.
Digital Marketing Perusahaan Ritel Indonesia Membangun Brand Image Fashion Footwear (Studi Kasus terhadap Onitsuka Tiger)
Authors: Ignabertha Janice Joceline , Loisa Riris
Published: January 2024

PT Mitra Adiperkasa Tbk (MAP) is a retail company that sells clothing, footwear, accessories, bags and sports equipment. Onitsuka Tiger, as one of the brands shaded by MAP, must be able to build a brand image so that it can be accepted by the Indonesian market. The purpose of this study is to describe how digital marketing communications are carried out by retail companies in an effort to build a brand image for fashion footwear products using descriptive qualitative research methods. Data collection techniques through in-depth interviews with research subjects and observations, document studies for reference for researchers in conducting research. The results of the study show that digital marketing PT MAP conducts marketing communications through four digital media channels to market Onitsuka Tiger, namely Search Engine Marketing (SEM), Social Media Marketing, Interactive Advertising, and Online PR. With good marketing communications, PT MAP aims to build the Onitsuka Tiger brand image. Overall, this study states that the use of digital marketing concepts has succeeded in building a good brand image for Onitsuka Tiger products. The author hopes that there will be further research based on developments in information technology related to marketing communications, as well as for PT MAP, namely to develop image branding through increasing digital marketing activities by involving consumers and studying marketing communication strategies more deeply.
PT Mitra Adiperkasa Tbk (MAP) merupakan perusahaan ritel yang menjual pakaian, alas kaki, aksesoris, tas dan perlengkapan olahraga. Onitsuka Tiger, sebagai salah satu brand yang dinaungi oleh MAP harus mampu membangun brand image agar dapat diterima oleh pasar Indonesia. Tujuan penelitian ini untuk menggambarkan bagaimana komunikasi pemasaran digital yang dijalankan perusahaan ritel, sebagai upaya membangun brand image produk fashion footwear dengan penggunaan metode penelitian kualitatif deskriptif. Teknik pengumpulan data melalui in-depth interview terhadap subjek penelitian dan observasi, studi dokumen untuk referensi bagi peneliti dalam membuat penelitian. Hasil penelitian menunjukkan bahwa digital marketing PT MAP melakukan komunikasi pemasaran melalui empat saluran media digital untuk memasarkan Onitsuka Tiger, yaitu Search Engine Marketing (SEM), Social Media Marketing, Interactive Advertising, dan Online PR. Dengan komunikasi pemasaran yang baik, PT MAP bertujuan untuk membangun brand image Onitsuka Tiger. Secara keseluruhan penelitian ini menyatakan bahwa penggunaan konsep digital marketing berhasil membangun brand image yang baik untuk produk Onitsuka Tiger. Penulis berharap adanya penelitian selanjutnya berdasarkan perkembangan teknologi informasi yang berkaitan dengan komunikasi pemasaran, serta bagi PT MAP yaitu untuk mengembangkan image branding melalui memperbanyak aktivitas digital marketing dengan melibatkan konsumen dan mengkaji strategi komunikasi pemasaran lebih dalam.
Representasi Komunikasi Asertif Ayah dan Anak dalam Film Ngeri-Ngeri Sedap (Analisis Semiotika Pierce)
Authors: Leonardo Leonardo , Azeharie Suzy
Published: January 2024

Film is part of a form of mass communication. The author conducted research on the film Missing Home on Netflix to find out the representation of assertive communication between fathers and children. This film tells the story of a husband and wife, Mr. Domu and his wife who live in a city in North Sumatra which is thick with Bataknese values and their four children who have chosen a way of life that goes against their father's wishes. The signs and gestures of the father figure named Pak Domu will be analyzed based on the semiotics of Charles Sanders Pierce. In this study the authors use conflict theory, face negotiation, assertive communication and Charles Sanders Pierce's semiotics. This research approach is qualitative with descriptive method. The data in this study were obtained through observation of the film, interviews with informants who know Bataknese culture and literature. Seven scenes were selected from the film, which consist of scenes of conflict, negotiation and assertive forms of communication that appear in each scene. The results of the study show that in the film Ngeri- Ngeri Sedap there is a family conflict beginning with Mr. Domu's attitude who forces his will on his four children so that his children and his wife protest and leave the house, then Mr. Domu negotiates by trying to adjust to his children's choices and being open on the differences and assertive communication patterns used by Mr. Domu in resolving his family conflicts.
Film merupakan bagian dari bentuk komunikasi massa. Penulis melakukan penelitian pada film Ngeri-Ngeri Sedap di Netflix untuk mengetahui representasi komunikasi asertif antara ayah dan anak. Film ini menceritakan sepasang suami istri, Pak Domu dan istrinya yang tinggal di satu kota di Sumatera Utara yang kental dengan nilai dan adat istiadat Batak dan empat anaknya yang memiliki pilihan jalan hidup yang bertentangan dengan keinginan ayahnya. Tanda dan gestur tokoh ayah yang bernama pak Domu akan dianalisis berdasarkan semiotika Charles Sanders Pierce. Dalam penelitian ini penulis menggunakan teori konflik, negosiasi wajah, komunikasi asertif serta semiotika Charles Sanders Pierce. Pendekatan penelitian ini adalah kualitatif dengan metode deskriptif. Data dalam penelitian ini didapat melalui observasi pada film tersebut, wawancara dengan narasumber yang mengetahui adat istiadat Batak dan studi pustaka. Dari film Ngeri-Ngeri Sedap dipilih tujuh adegan yang terdiri dari adegan konflik, negosiasi dan bentuk komunikasi asertif yang muncul dalam setiap scenenya. Hasil penelitian menunjukan bahwa dalam film Ngeri-Ngeri Sedap terdapat konflik keluarga diawali dengan sikap pak Domu yang memaksakan kehendak kepada keempat anaknya sehingga anak anaknya juga istrinya protes dan meninggalkan rumah, lalu pak Domu melakukan negosiasi dengan mencoba menyesuaikan diri dengan pilihan anak anaknya serta bersikap terbuka pada perbedaan dan pola komunikasi asertif yang dilakukan pak Domu dalam menyelesaikan konflik keluarganya.
Analisis Motivasi Pecinta Budaya Jepang dalam Membeli Kaos Uniqlo X Jujutsu Kaisen
Authors: Marcella Marcella , Pandrianto Nigar
Published: January 2024

This research is about a person’s desire to make a decision to buy merchandise. Popular Japanase culture entered Indonesia, including in the form of anime and manga. Making fans want to buy their favorite anime merchandise and make purchasing decisions. Motivation consists of intrinsic motivation. There are five stages of purchasing decisions starting form identification of needs, information search, evalution of alternatives, purchase decisions and post-purchase behavior. This study uses a qualitative methodology and case studies. The results of this study were to find out how motivated Jakarta Otaku are in purchasing decisions for Uniqlo X Jujutsu Kaisen T-Shirts. Purchase motivation can also be related to a person’s level of parasocial. The higher parasocial level, the more fans will want to buy merchandise. Uniqlo’s collaboration with Jujustu Kaisen in Indonesia can be said to have attracted the attention of Otaku. Evidenced by the fact that almost all Uniqlo outlets in Indonesia have run out of stock.
Penelitian ini mengkaji tentang keinginan seseorang dalam mengambil keputusan pembelian merchandise. Masuknya kebudayaan Jepang populer ke Indonesia di antaranya dalam bentuk anime dan manga membuat para penggemar ingin membeli merchandise anime favoritnya. Hal tersebut membuat adanya motivasi para penggemar untuk membeli merchandise dan membuat keputusan pembelian. Motivasi terdiri dari motivasi instrinsik dan motivasi ekstrinsik. Keputusan pembelian ada lima tahapan yang dimulai dari mengenali kebutuhan, pencarian informasi, evaluasi alternatif, keputusan pembelian dan perilaku pasca pembelian. Penelitian ini menggunakan pendekatan kualitatif dan metode studi kasus. Hasil penelitian ini adalah ingin mengetahui bagaimana motivasi otaku Jakarta dalam keputusan pembeliankaos Uniqlo X Jujutsu Kaisen. Motivasi pembelian juga dapat dikaitkan dengan tingkat interaksi parasosial seseorang. Semakin tinggi tingkat tingkat parasosial maka penggemar akan semakin ingin membeli merchandise. Kolaborasi Uniqlo dengan Jujutsu Kaisen di Indonesia bisa dikatakan banyak menarik perhatian otaku. Terbukti dengan habisnya persediaan hampir di seluruh gerai Uniqlo di Indonesia.
Dovetailing the human resource management with the cloud computing in the era of industry 4.0: A review
Authors: Sharma Dipanker , Salehi Waleed , Bhardwaj Bhawana , Chand Mohinder , Salihy Hasiba
Published: January 2024

The Current review evaluates the human side of Industrial Revolution which is blending the physical, biological, and digital worlds, erasing the borders between technology and human. The Current article examines the potential benefits of Cloud Computing (CC) in the area of HR, and their significant advantages in various HRM processes and highlights the development and trends in the industrial revolution. The 44 articles were retrieved from free search engines like Google scholar, Proquest, Research Gate and Google from (2010-2022). The articles selected through this process were carefully analyzed to synthesize existing knowledge. The findings emphasized that cloud based HRMS offers distinctive advantages to enhance efficiency and cost-effectiveness. The review surfaces that innovative programs have disrupted traditional HR management practices by transitioning the company's segregated in-house HRMS to the cloud. The organizations; implementing and practicing such technologies have gained competitive edge over their rivals. Additionally, cloud computing facilitates efficient resource utilization, seamless scalability, elimination of hardware and software maintenance requirements, and reliable data recovery capabilities. The study suggests strategies on how HR must create a digital workplace that can innovate, collaborate, and tackle business issues.
Piloted Simulation-Based Assessment of Simplified Vehicle Operations for Urban Air Mobility
Authors: Chakraborty Imon , Comer Anthony , Bhandari Rajan , Putra Stefanus Harris , Mishra Aashutosh Aman , Schaller Ross , Sizoo David , McGuire Robert
Published: January 2024

This work investigates the simplified vehicle operations paradigm, which seeks significant reductions in pilot workload and training requirements through the holistic design of flight control laws, control inceptors, and cockpit displays in the context of vertical takeoff and landing urban air mobility aircraft using piloted flight simulations. Two inceptor layouts, one similar to conventional fixed-wing aircraft and the other similar to conventional rotorcraft, differing in inceptor-to-command mappings, were incorporated into two research flight simulators. A lift-plus-cruise aircraft simulation model, a total energy control system–based fly-by-wire flight control architecture, and identical cockpit displays were used for both setups. Twenty-one participants, divided into three groups based on their prior piloting experience, were used to study pilot performance using representative handling qualities task elements. The piloted simulation data revealed that participants in each group were able to successfully perform the simulation tasks and allowed handling quality ratings to be calculated. They also highlighted instances of control coupling between inceptor axes in each setup for different tasks and the relative ease or difficulty of performing each task with the two inceptor designs.
Avoiding the Danger of Rising Resistance in Cutibacterium acnes: Criticality of Benzoyl Peroxide and Antibiotic Fixed Combinations
Authors: Ghannoum Mahmoud , Gamal Ahmed , Kadry Ahmed , Del Rosso James , Bunick Christopher , Stein Gold Linda , Kircik Leon , Harper Julie
Published: January 2024

Background: Antibiotic resistance is a global concern, with several countries reporting resistance in >50% of Cutibacterium acnes (C. acnes) strains. Combination formulations containing an antibiotic and the antimicrobial benzoyl peroxide (BPO) may reduce this resistance risk, especially with prolonged use. This four-part study tested susceptibility of 31 C. acnes clinical strains to antibiotics alone or in combination with BPO.

Methods: Part 1: C. acnes susceptibility to single-drug antibiotics was assessed via minimum inhibitory concentration (MIC) values obtained from epsilometer tests, with lower MIC indicating higher susceptibility. Part 2: Susceptibility to fixed-dose antibiotic/BPO combination products (branded/in-development) was determined by measuring zone of inhibition using agar diffusion method, with larger diameter indicating increased bacterial inhibition. Part 3: The effect (synergistic, additive, antagonistic, or neutral) of combining clindamycin with BPO on C. acnes inhibition was evaluated using a checkerboard assay, wherein two test compounds are combined in varying concentrations. Part 4: Development of resistance was assessed using serial passage of bacterial cultures in increasing concentrations of clindamycin alone or in combination with BPO.

Results: Part 1: All antibiotics tested—clindamycin, doxycycline, erythromycin, and minocycline—had similar activity. Susceptibility was highly strain dependent, as some C. acnes strains had elevated MIC—an indication of resistance—against different antibiotics. Part 2: For the 6 C. acnes strains that had no inhibitory zone (0 cm) with clindamycin alone, formulations with BPO enhanced activity against the same isolates (range: 0.8-2.2 cm with clindamycin phosphate 1.2%/adapalene 0.15%/BPO 3.1%, clindamycin phosphate 1.2%/BPO 5%, or clindamycin phosphate 1.2%/BPO 3.75%). Part 3: The combination of clindamycin and BPO resulted in an additive effect for 4 of the 7 acne-associated strains tested and was neutral for 3 strains. Part 4: Bacterial cultures repeatedly exposed to a combination of clindamycin and BPO did not develop resistance to C. acnes, which occurred with exposure to antibiotic alone.

Conclusions: Overall, antibiotic susceptibility was highly strain dependent and antibiotic formulations with BPO exhibited enhanced activity against less susceptible C. acnes strains. Fixed combinations of BPO with an antibiotic may improve antimicrobial activity and protect against resistance development.

 

Funding: Ortho Dermatologics.
Dampak Negatif Gadget pada Perilaku Agresif Anak Usia Dini
Authors: Iftaqul Janah Anwardiani , Diana Raden
Published: January 2024

Technology that is currently developing has an influence on aggressive behavior in children, so there needs to be prevention efforts in this deviant behavior. The purpose of this study was to determine the influence of gadgets and the factors that cause aggressive behavior, forms of aggressive behavior, the impact of aggressive behavior, and efforts to handle aggressive behavior in early childhood. The method used in this research is a case study which is presented with a qualitative descriptive research type by presenting the data in a narrative manner, as well as data obtained through observation. In this study, the subject is one girl who behaves aggressively aged 5-6 years because of the influence of unlimited gadgets. The results of the research obtained are the influence of the use of gadgets that are not restricted and supervised. This causes aggressive behavior in children who find it difficult to control their desire to convey messages, such as shouting, crying, and making physical contact when someone interferes with playing gadgets. The influence of gadgets on aggressive behavior in children requires serious efforts for parents or adults who are around children so that they do not have a negative impact on children's development in the future.
Baldwin and Whitehead’s Manzamine Alkaloids Biosynthesis Hy-pothesis Involves a Finely Tuned Reactivity of C3 Unit: a High-Throughput Experimentation Approach
Authors: Leblond Axel , Nguyen Alexandre , Alcover Charlotte , Leblanc Karine , Gallard Jean-François , Joseph Delphine , Poupon Erwan , Beniddir Mehdi
Published: January 2024

A rapid analysis of mass spectrometry data generated from 96 multicomponent reactions using a herein-provided chemoinformatic workflow, have pinpointed relevant conditions tuning the reactivity of acrolein to fulfill Baldwin and Whitehead’s manzamine alkaloids biosynthetic hypothesis. This strategy can become part of a general method for the analysis of information-rich high-throughput experiments of multicomponent reactions applied to natural product biosynthetic scenario
Advancing Material Property Prediction: Using Physics-Informed Machine Learning Models for Viscosity
Authors: Chew Alex K. , Sender Matthew , Kaplan Zachary , Chandrasekaran Anand , Chief Elk Jackson , Browning Andrea R. , Kwak H. Shaun , Halls Mathew D. , Afzal Mohammad Atif Faiz
Published: January 2024

In materials science, accurately computing properties like viscosity, melting point, and glass transition temperatures solely through physics-based models is challenging. Data-driven machine learning (ML) also poses challenges in constructing ML models, especially in the material science domain where data is limited. To address this, we integrate physics-informed descriptors from molecular dynamics (MD) simulations to enhance the accuracy and interpretability of ML models. Our current study focuses on accurately predicting viscosity in liquid systems using MD descriptors. In this work, we curated a comprehensive dataset of over 4,000 small organic molecules’ viscosities from scientific literature, publications, and online databases. This dataset enabled us to develop quantitative structure–property relationships (QSPR) consisting of descriptor-based and graph neural network models to predict temperature-dependent viscosities for a wide range of viscosities with considerable accuracy. The QSPR models reveal that including MD descriptors improves prediction accuracies of experimental viscosities, particularly at the small data set scale of fewer than a thousand data points. Furthermore, feature importance tools reveal that intermolecular interactions captured by MD descriptors are most important for accurate viscosity predictions. Finally, the QSPR models can accurately capture the inverse relationship between viscosity and temperature for six battery-relevant solvents, some of which were not included in the original data set. Our research highlights the effectiveness of incorporating MD descriptors into QSPR models, which leads to improved accuracy for properties that are difficult to predict when using physics-based models alone or when limited data is available.