bluuebunny/crossref_metadata_2025 huggingface dataset:
El río Los Patos no se toca. Reflexiones sobre igualdad, libre determinación y autonomía de los pueblos en contextos extractivistas
Authors:   Eda-UNCA, Fernández Luciana
Published: August 2023

En el siguiente texto abordaremos el avance del extractivismo sobre los salares altoandinos, integrantes del “triángulo del litio”, intentando comprender los impactos socioambientales a partir de las perspectivas de las comunidades locales. Por otra parte se intentará profundizar en las estrategias que los pueblos llevan adelante para la defensa de sus territorios, teniendo en cuenta que el cuidado del agua pasa a ser una cuestión fundamental. En este caso, la defensa del río Los Patos (Antofagasta de la Sierra, Catamarca), moviliza a los habitantes de la puna catamarqueña, que van tejiendo alianzas con otros colectivos, para fortalecerse. El motivo es frenar el avance de las empresas litíferas sobre el río, como elemento vital fundamental, como garante de la vida, y en este sentido, como ser con agencia que es parte y a la vez sostén del mundo puneño, trama de la red de relaciones que sostienen el mundo en el Salar del Hombre Muerto.
Organizaciones comunitarias que suministran agua, legado del buen vivir en contraste con la normatividad colombiana
Authors:   Universidad Nacional de Colombia, Quintana-Ramírez Ana Patricia , Bernal Pedraza Andrea
Published: August 2023

Las organizaciones comunitarias proveen agua a cerca de 20.000 comunidades en Colombia, que se rige por un marco normativo e institucional orientado bajo las premisas del desarrollo sostenible y la gestión empresarial. Esto entraña una fuerte contradicción entre los sentidos comunitarios y del buen vivir que devienen de una historia común de esfuerzo colectivo para abastecer con agua a gran parte de la población rural-urbana en Colombia. Las investigadoras presentan una revisión documental de la evolución histórica y de la normativa aplicable a estas organizaciones comunitarias, y posteriormente desde la escucha de las voces de los lideres y lideresas de organizaciones comunitarias afiliadas a la Confederación de Organizaciones Comunitarias de Servicios de Agua y Saneamiento de Colombia [COCSASCOL] con presencia en los departamentos del Valle del Cauca, Cauca, Risaralda y Cundinamarca, se caracterizan las contradicciones que se viven en el territorio frente al marco normativo.
Qualidade da prescrição de terapêutica de alívio na asma em cuidados de saúde primários
Authors:   Unidade de Saúde Familiar São Martinho de Alcabideche, ACeS Cascais, Portugal, Pires João , Leite Raquel ,   Unidade de Saúde Familiar São Martinho de Alcabideche, ACeS Cascais, Portugal, Moita Catarina ,   Unidade de Saúde Familiar São Martinho de Alcabideche, ACeS Cascais, Portugal, Silva Ana ,   Unidade de Saúde Familiar São Martinho de Alcabideche, ACeS Cascais, Portugal, Florova Violeta ,   Unidade de Saúde Familiar São Martinho de Alcabideche, ACeS Cascais, Portugal
Published: August 2023

A atualização de 2020 da Global Initiative for Asthma (GINA) trouxe mudanças relativamente à gestão farmacológica dos doentes asmáticos, que perduram até à atualidade. Destaca-se a recomendação universal, em indivíduos com idade superior a 12 anos, da utilização de corticosteroide inalado (ICS) como terapêutica de controlo para uma redução do risco de agudizações, bem como a advertência para os riscos inerentes à utilização isolada de agonista beta2 de curta ação de duração (SABA) como terapêutica de alívio, sendo fortemente aconselhada a sua substituição ou associação com ICS desde os estádios mais precoces de doença. Objetivos: Avaliar a qualidade da prescrição de terapêutica de alívio na asma ligeira-moderada numa unidade de cuidados de saúde primários (CSP). Paralelamente, procedeu-se à análise demográfica dos fatores de risco e provas de função respiratória nestes doentes. Métodos: Estudo transversal descritivo que incluiu todos os utentes inscritos com seguimento na unidade de estudo, com idade igual ou superior a 12 anos, codificados com asma como problema ativo e com terapêutica inalatória de alívio prescrita nos dois anos prévios. Resultados: Foram incluídos 271 utentes depois de aplicados os critérios mencionados. A maioria não tinha ICS incluído na terapêutica de alívio (72,5%), estando 87,9% medicados apenas com SABA. Não havia registo de qualquer espirometria em 45,8% dos doentes. Os fatores de risco mais prevalentes eram a rinite alérgica, obesidade e tabagismo. Conclusões: A prescrição de terapêutica de alívio da maioria dos utentes não vai ao encontro das recomendações internacionais atuais, aumentando o risco de agudizações, hospitalizações e mortalidade associadas à asma. Também foi possível aferir a reduzida codificação de asma, a escassa avaliação e/ou reavaliação da função pulmonar com espirometria e a elevada prevalência de fatores de risco modificáveis bem conhecidos, onde a intervenção médica precoce tem um papel preponderante.
Evaluation of organo-mineral qualities of combusted compost floor litters in Achalla forest reserve on early growth responses of Dacryodes edulis H. J. Lam
Authors: Egwunatum Anselm Enwelem , Emilimor Patience Ndidi , Emma-Otum Nneka Sophia , Doreen Alukwe
Published: August 2023

This study evaluated the potential of compost-combusted forest litters as alternative sources of ex-situ organo-mineral products to the direct use of controlled fire for enhanced soil nutrients in forest stands. Floor litters from six (6) delineated standing forest patches of Pterocarpus erinaceus, Gmelina arborea, Tectona grandis, Bambusa vulgaris, Ceiba pentandra and Mangifera indica were characterized for N, K, P, Ca and Mg;  composted for 3, 6, 9 and 12 days and then uniformly combusted to produce organo-minerals for early growth response of Dacryodes edulis in a 6 x 4 split-plot factorial experiment. Analysis of variance was conducted for litter characteristics, calorific values, moisture, ash contents, and germination and growth variables of Dacryodes edulis while significant means were separated with DMRT (p ≥ 0.05). Results showed that Mangifera had the highest P (0.68%) and K (1.15%); Bamboo had the highest N (1.92%). Germination was 6>9>12> 3 days with Bamboo > Ceiba > Teak > Mangifera > Gmelina > Pterocarpus for  6 days organo-minerals, but the highest height (21.56 ± 6.77 cm) by Pterocarpus to implicate litters under microbe-thermal mediation as sustainable organo-mineral ex-situ products to combat incidence of forest fire for fertile forest soil. Thus, in-situ controlled fire in standing forests is no longer needed for nutrient-rich forest-agriculture.
Int. J. Agril. Res. Innov. Tech. 13(1): 31-37, June 2023
Evaluation of irrigated rice (Oryza sativa L.) varieties under irrigation condition at Dasenech Distinct, South Omo Zone
Authors: Tadesse Awoke , Jerjero Temesgen
Published: August 2023

Rice crop is essential in a country. Still, the production and productivity are low due to uncovering a suitable area for rice production and the shortage of improved and unedited well-adapted variety. To solve this problem, the study was conducted in Dasenech district during (2020/21 and 2021/22) cropping seasons to select well-adapted varieties. The study contains 6 varieties (Gode, Shebele, Chewaqa, Kallafo, Nerica-15, and Pawe-2). For this study used a randomized complete block design with three replications. Yield and other trait data were collected and subjected to analysis of variance. The result of the analysis of variance showed that all parameters were significantly affected among tested rice varieties. The Pawe-2 variety gave the highest grain production (6284.7 kg ha-1) among the tested varieties.  Based on the study result, it can be suggested that variety Pawe-2 perform well and is suitable for agro-pastoral in the Dasenech area under irrigation condition and its similar agro-ecology.
Int. J. Agril. Res. Innov. Tech. 13(1): 38-41, June 2023
PERBANDINGAN KINERJA REKSA DANA SYARI’AH DAN REKSA DANA KONVENSIONAL YANG TERCATAT DI IPOT FUND PERIODE 2018-2020
Authors: Amar Reza Nurul Amar , Kamaludin  , Kananlua Paulus Sulluk Kananlua
Published: August 2023

Abstract :

This research aims to analyze the performance comparison between conventional mutual funds and shariah mutual funds listed in Ipot fund periods 2018-2020. Variables that are used in this research are mutual funds net asset value and Sharpe ratio. By using purposive sampling method there are 69 conventional equity funds, 14 sharia equity funds, 39 conventional fix income and 7 sharia fix income. This research used the difference the average yield of mutual funds to analyze performance between conventional and sharia mutual fund. The result showed that the average conventional and sharia mutual funds do not have significantly different performance. The sharpe ratio average value showed that sharia mutual funds have higher return than conventional mutual funds.

 

Keywords :  Mutual Funds Performance, Net asset value, Sharpe and Ipot Fund.

 

Abstrak :

Penelitian ini bertujuan untuk menganalisis perbandingan kinerja reksa dana konvensional dengan reksa dana syariah yang terdaftar di Ipot fund periode 2018-2020. Variabel yang digunakan dalam penelitian ini adalah nilai aktiva bersih reksa dana dan rasio Sharpe. Dengan menggunakan metode purposive sampling terdapat 69 reksa dana saham konvensional, 14 reksa dana saham syariah, 39 pendapatan tetap konvensional dan 7 pendapatan tetap syariah. Penelitian ini menggunakan perbedaan rata-rata yield reksa dana untuk menganalisis kinerja reksa dana konvensional dan syariah. Hasil penelitian menunjukkan bahwa rata-rata reksa dana konvensional dan syariah tidak memiliki perbedaan kinerja yang signifikan. Nilai rata-rata sharpe ratio menunjukkan bahwa reksa dana syariah memiliki return yang lebih tinggi dibandingkan reksa dana konvensional.

 

Kata Kunci : Kinerja Reksa Dana, Nilai Aktiva Bersih, Sharpe dan Ipot Fund.
Human Resources Management System At Police Resort Bengkulu Utara
Authors: Jufri Jufri , Widodo Slamet , Pareke Fachrudin Js
Published: August 2023

The purpose of the research was to describe how to arrange the police management system of human resource in the reformation era. Specifically, the study examined the aspects of the fulfillment and the reform of the police human resource management system. The Police officers who worked at the police headquarters in North Bengkulu Regency, termed Polres, treated as the sample in this study. The study employed a descriptive qualitative approach and used a survey questionnaire to collect the main data. The returned questionnaires that were filled out by 241 police, were then analysed using descriptive statistics of mean, percentage, and frequency. The results of the study show that in general the arrangement of the human resource management system has been going well. Of the six assessments on the fulfillment aspect, namely planning for personnel needs, patterns of mutation, personnel development, setting individual performance standards, enforcement of discipline, and personnel information systems, are in accordance with the Decree of the Chief of Police and ministerial regulations. However, from the aspect of reform, one out of three punishments, namely disciplinary violations, has not shown a significant reduction. Even though within the Polri organization there is an element of oversight, the control mechanism through SiPropam faces dilemmatic situations and conditions due to the influence of a sense of corps, seniority relations, and an excessive sense of loyalty to friends which makes it weak in its implementation. Likewise Kompolnas, which should be in Law Number 2 of 2002 concerning the Police to be formed as an external supervisor, in fact it is only formulated as an "advisor" to the president in the field of police and the people who receive complaints, which are injured by members of the National Police..
 
Keywords: Management System, Human Resources Management, Police, Reform
Effect of Social Media Marketing Variables on Marketing Performance of MSMEs in Indonesia
Authors: Nauli Arthika , Anggarawati Sularsih , Abdillah Willy
Published: August 2023

The purpose of this study is to find out the effect of social media marketing variables on MSME marketing performance in Indonesia. The type of this research is descriptive research with a quantitative approach. The type of data used is primary data obtained through the distribution of questionnaires. The respondents of this research are MSME actors in Indonesia who use social media in product marketing, the total number of respondents is 205 people. Respondents were taken by non probability sampling and were obtained by distributing online questionnaires. The data analysis methods used are  descriptive analysis and multiple regression analysis. Based on field research, the results show that: (1) The variable of content in social media marketing activities have a positive and significant influences on the marketing performance of MSMEs in Indonesia. Therefore, if the information presented in social media marketing is getting better, then the marketing performance of MSMEs will increased; (2) The context variable in social media marketing activities has a positive and significant impact on the marketing performance of MSMEs in Indonesia. Therefore, if the information is presented in the right context on social media marketing, then the marketing performance of MSMEs will increased; and (3) The connection variable in social media marketing activities has a positive and significant impact on the marketing performance of MSMEs in Indonesia. Therefore, if the social media used by MSMEs is well connected with other sites, the MSME marketing performance will increased.

 

Keywords:  Content, Context, Connection and Marketing Performance
Effects Of Discounts, Brand Image And In-Store Display Against Impulsive Buying In Fashion Products At Matahari Department Store Bengkulu
Authors: Janur NZ. Annisa , Salim Muhartini , Anggarawati Sularsih
Published: August 2023

The purpose of this study is to analyze the effect of the discount, brand image and in-store display toward impulsive buying at the Matahari Department Store in the Bengkulu City. The data used in this research is the primary data obtained from the questionnaire to the dissemination of the results of the customers of the Matahari Department Store in the Bengkulu City. The sample used in the analysis was 185 respondents. Data analysis method used is descriptive analysis and multiple linear regression analysis. From hypothesis testing retrieved results: first, the discount variable has a positive significant effect on impulsive buying.  Its means are, if the discount is good, will be increasing of customers to impulsive buying. Second, the brand image variable has positive and significant effect on impulsive buying. Its means are, if the brand image is good, will be increasing of customers to impulsive buying. Third the in-store display variable has positive and significant effect on impulsive buying. Its means are, if the in-store is good, will be increasing of customers to impulsive buying.

Keywords: Discount, Brand image, In-store display and Impulsive buying
Triagem de sarcopenia em idosos hospitalizados pelos métodos SARC-F e SARC-CALF e fatores associados
Authors: Pita Dhaiane Alves Araujo , Martinelli Martha de Oliveira , Fogaça Leidiane Lacerda , Caires Vitória Santos , Oliveira Araceles Barbosa , França Vivian Francielle , Cardoso Luiz Gustavo Vieira
Published: August 2023

Objetivo: rastrear o risco de sarcopenia e fatores associados em idosos hospitalizados, aplicando os métodos de triagem SARC-F e SARC-CALF. Metodologia: trata-se de um estudo transversal realizado entre maio e outubro de 2022 em idosos internados na emergência de um hospital público. As informações referentes à idade, sexo, diagnóstico e comorbidades foram coletadas em prontuário. Os dados socioeconômicos foram obtidos por meio de questionário. Realizou-se triagem do risco nutricional, avaliação antropométrica e aplicação das ferramentas de triagem SARC-F e SARC-CALF. A associação entre o risco de sarcopenia e variáveis independentes foi obtida através de regressão logística binária, utilizando odds ratio (OR) e intervalo de confiança de 95%. Foram consideradas associadas às variáveis que apresentaram nível de significância de 5%. Resultados: foram avaliados 225 idosos, 53,3% apresentaram risco de sarcopenia de acordo com o SARC-F e 49,8% segundo o SARC-CALF. Ambas as ferramentas se mostraram associados ao sexo feminino, idade maior ou igual a 80 anos, risco de desnutrição e desnutrição de acordo com a MAN. Somente o SARC-F associou a doenças pregressas. Apenas o SARC-CALF associou a escolaridade, estado nutricional e depleção da espessura do músculo adutor do polegar. Conclusão: ambas as ferramentas se mostraram como métodos viáveis, de baixo custo e fácil aplicação. Observou-se que o número de idosos admitidos na unidade hospitalar com risco de sarcopenia é elevado. Assim, é de extrema importância inserir a aplicação das triagens de sarcopenia na rotina admissional, para nortear os profissionais de saúde e proporcionar intervenção visando à prevenção e recuperação desses indivíduos.
Internações e mortes por fratura de fêmur no Brasil com ênfase no Estado do Pará entre os anos 2010 e 2020
Authors: Silva Vilmar Carneiro da , Silveira Geison Victor Gonçalves , Rodrigues Diego Romani da Costa , Bandeira Maria Jose da Silva , Souza Adão Ferreira de , Campos Davi Gonçalves , Siqueira Neto Antônio Carmo da Costa , Maciel Rodrigo Tavares , Cardoza Yuri Antônio Fonseca , Sousa Ingrid Vitória Genú Mendes de
Published: August 2023

Introdução: O fêmur é o osso mais longo e volumoso do corpo humano, localizado na coxa. Sua extremidade superior se articula com a bacia, formando a articulação do quadril, permitindo assim movimentos de extensão, flexão e rotação. A região proximal do fêmur é particularmente suscetível a fraturas, sendo considerada uma das áreas mais comuns para esse tipo de lesão óssea. Objetivo: Este estudo buscou conhecer o caráter epidemiológico das internações dessa fratura na população brasileira com ênfase no Estado do Pará. Este estudo é um estudo ecológico que utilizou dados do Sistema de Informações Hospitalares (SIH/SUS) para analisar indivíduos que foram internados no Sistema Único de Saúde (SUS) no Brasil por causa de fratura de fêmur entre janeiro de 2010 e dezembro de 2020. Resultados: O Pará possui o maior número de internações e mortes decorrentes de fraturas de fêmur. A Região Metropolitana I, composta por Belém e Ananindeua, concentra a maior parte das internações e óbitos relacionados a esse tipo de fratura. A faixa etária com maior número de internações e óbitos é acima de 80 anos. A internação é mais frequente entre homens, mas o maior número de óbitos ocorre na proporção 1:1. Além disso, o município de Ananindeua apresenta o maior número de óbitos, seguido por Belém. Conclusão: conclui-se que é crucial programar medidas efetivas de prevenção de quedas a fim de reduzir o número de internações e óbitos por fratura de fêmur no Estado do Pará.
Documentation in Continuous Software Development
Authors:   , Theunissen Theodorus Anthonius Maria
Published: August 2023

With the introduction of the Agile Manifesto, Lean Software Development, and Dev-Ops, documentation has become lower in quality and lesser in quantity leading to knowledge evaporation.
The Agile Manifesto values working software over comprehensive documentation, and Lean Software Development considers everything that does not contribute to customer value as waste. In Dev-Ops, documentation is primarily found in infrastructure-as-code to keep up with continuously changing legislation and demands for fast time-to-market.
Next to the developments above, another issue causing knowledge evaporation concerns the reluctance of software developers to write down information about a software product. In general, software developers and other stakeholders dislike reading documentation; in short, TL;DR.
New team members must invest substantial time in comprehending the intentions behind the source code, particularly understanding the reasons for its functioning and extracting insights into how it operates, all directly from the source code itself.
The source code alone cannot reveal design decisions or their rationale. Consequently, preserving knowledge necessitates primarily capturing design decisions, rationale, architecture and justification.

To mitigate knowledge loss, we formulated three primary research questions that subsequently informed the development of a framework consisting of three approaches and their corresponding artifacts. The first question poses challenges due to culture, loss of focus, and a wide array of tools and processes. The second question examines the characteristics of gls{csd}, including cultural traits defined by values, principles, practices, and processes, life cycle attributes of constant change, systematic challenges like lack of control, and the impact of bugs and new features. The third research question proposes a framework with approaches and artifacts.

The approaches in the framework are `Just Enough Upfront', ‘Executable Documentation', and ‘Automatic Text Analysis'. ‘Just Enough Upfront' advocates informal whiteboard sketches to communicate the main objectives between stakeholders, a strictly codified interface description between (sub)systems, and a plan of approach. Afterward, developers document design decisions to incorporate progressive insights and deviations from the initially planned objectives. The characteristics of `Executable Documentation' pertain to human-readable requirements and specifications that can be executed. This approach is typically in use when specifications are clearly defined. With ‘Automatic Text Analysis', machine learning with neural networks is used to identify causal relations in text, especially Git comments, for revealing design decisions. As such, this approach assists in retrieving knowledge.
The End of History in EU Law and Politics? Challenging Founding Narratives with a New Research Agenda
Authors: Cheruvu Sivaram , Pavone Tommaso
Published: August 2023

We reassess two foundational narratives of European legal integration that appeared to corroborate “end of history” claims in post-Cold War international and comparative politics research. The first narrative asserts that EU law was locked-in by a virtuous cycle of cooperative national courts applying international rules and governments increasingly deferring to judges. The second narrative posits that the enlargement of the EU bolstered states’ commitment to the rule of law and the European Commission’s resolve to act as “Guardian of the Treaties.” Drawing on dozens of recent studies and novel data, we demonstrate that judicial and political conflicts continue to destabilize the EU legal order and that the on-the-ground authority of EU law has become more uneven over time. To overcome teleological theories of a more institutionalized and law-abiding EU, we propose a new agenda anchored in the concept of “intercurrence:” the overlapping and often conflictual operation of politically-embedded legal orders.
Electoral predictors of polling errors
Authors: Chen Sina , Körtner John , Selb Peter , Wiederspohn Jens
Published: August 2023

Case studies of polling failures focus on within-election differences in poll accuracy. The crucial question of why polls fail in one election but not in others often remains a matter of speculation. To develop a contextual understanding, we review and unify theories of election features suspected of encouraging polling errors, including mobilization, candidacies, polarization, and electoral conduct. We extend a Bayesian hierarchical modeling approach that separates poll bias and variance at the election level and links error components to electoral predictors. Investigating 9,298 pre-election polls across 367 U.S. Senate elections, 1990-2022, we find an overall trend toward smaller but more uniform errors. Poll variance is negatively associated with mobilization and polarization. Until 2004, frontrunners and incumbents were overestimated, but there is little evidence that polls are biased for female or minority candidates. Finally, Republicans in states with lower levels of state democracy have been underestimated in recent years.
Implementasi Ekstraksi Fitur GLCM dengan Klasifikasi Algoritma C5.0 Pada Data Computerized Tomography Scan Covid-19
Authors: ROFIQ MUHAMMAD , Saragih Triando Hamonangan , Nugrahadi Dodon Turianto
Published: August 2023

Teknologi pencitraan digital telah banyak digunakan dalam bidang medis dalam diagnosis data citra biologis untuk memandu dokter untuk mengetahui kondisi pasien. Salah satu teknik pencitraan medis yang dapat menggambarkan kondisi di dalam tubuh manusia adalah Computed Tomography (CT). Penelitian ini menggunakan dataset citra CT scan dada berjumlah 625 data CT. Ekstraksi fitur yang digunakan untuk mendapatkan beberapa fitur statistik tentang citra adalah GLCM (Gray Level Co-Occurrence Matrix). Dalam GLCM Jarak direpresentasikan sebagai piksel sedangkan orientasi direpresentasikan dalam derajat. Orientasi terbentuk dari empat arah sudut dengan interval 0°, 45°, 90°, dan 135°. Sedangkan jarak antar piksel biasanya ditetapkan sebesar 1 piksel. Setelah dilakukan ektraksi fitur akan dilakukan klasifikasi dengan menggunakan metode algoritma C5.0 Hasil akurasi dari metode klasifikasi C5.0 menggunakan ektraksi fitur GLCM mendapatkan hasil akurasi sebesar 87% pada sudut 90°, 84% pada sudut 45°, 83% pada sudut 135°, dan 82% pada sudut 0°.
SISTEM PREDIKSI PENJUALAN MENGGUNAKAN METODE WEIGHTED MOVING AVERAGE DAN ECONOMIC ORDER
Authors: Erdianita Davila , Mumpuni Retno , Aditiawan Firza Prima
Published: August 2023

Toko Mariah merupakan sebuah toko yang menjual beraneka ragam barang kebutuhan sehari – hari. Pada Toko Mariah masih menggunakan perkiraan dalam menetapkan jumlah persediaan barang yang dibutuhkan untuk bulan selanjutnya, hal ini menyebabkan permasalahan yaitu kekurangan persediaan barang dan penumpukan barang. Selain itu, permasalahan yang muncul di Toko Mariah yaitu permintaan pelanggan yang tidak dapat terpenuhi karena barang yang dibutuhkan belum tersedia yang berdampak pada penurunan keuntungan. Untuk menyelesaikan permasalahan yang ditemukan, Toko Mariah memerlukan suatu sistem prediksi penjualan dan persediaan barang. Penelitian ini menggunakan metode Weighted Moving Average yang digunakan untuk memprediksi penjualan pada periode mendatang dan Economic Order Quantity yang digunakan untuk menentukan pemesanan barang yang optimal agar dapat meminimalkan biaya serta tidak terjadinya penumpukan dan kekurangan persediaan barang. Pengujian akurasi hasil prediksi pada penelitian ini menggunakan MAPE, MAD dan MSE. Nilai rata – rata hasil uji akurasi  prediksi dengan menggunakan MAD, MSE dan MAPE untuk 5 data prediksi penjualan barang adalah 5,16, 39,97 dan 13,45%.
ANALISIS SENTIMEN BRAND AMBASSADOR BTS TERHADAP TOKOPEDIA MENGGUNAKAN KLASIFIKASI BAYESIAN NETWORK DENGAN EKSTRAKSI FITUR TF-IDF
Authors: Regina  , Saragih Triando Hamonangan , Kartini Dwi
Published: August 2023

BTS (Bangtan Boys) adalah salah satu boy grup asal korea selatan yang ditunjuk oleh Tokopedia untuk menjadi brand ambassador Tokopedia di Indonesia, BTS merupakan salah satu boy grup yang sangat mendunia dalam bidang musik dan Tokopedia merupakan salah satu E-commerce terkenal yang banyak digunakan oleh masyarakat indonesia untuk melakukan jual beli online. Kerjasama ini tentu saja memberikan pengaruh terhadap Tokopedia serta memperoleh banyak respon berupa opini masyarakat terutama pada media sosial twitter, karena hal tersebut maka dilakukan penelitian analisis sentiment. Data yang digunakan yaitu 900 data tweet dan terbagi menjadi 3 kelas yaitu positif, negatif, dan netral. Tahapan penilitian terdiri dari pengambilan dan pengumpulan data, preprocessing data, ekstraksi fitur dengan Term Frequency - Inverse Document Frequency (TF-IDF), klasifikasi dengan Bayesian network, evaluasi kinerja menggunakan K-fold cross validation (K-10) dan confution matrix. Perbandingan terjadi pada tahap preprocessing data, yaitu saat menggunakan normalisasi data dan tidak menggunakan normalisasi data, dari hasil perbandingan tersebut diperoleh nilai akurasi jika tidak menggunakan normalisasi data sebesar 66,6667%, presisi sebesar 68,1%, dan recall sebesar 66,7%. Sedangkan hasil akurasi dengan menggunakan normalisasi data sebesar 76,5556%, presisi sebesar 77,4%, dan recall sebesar 76,6%. Selisih nilai akurasi dari kedua percobaan sebesar 9,8889 %, hal ini membuktikan bahwa menggunakan normalisasi data lebih baik.
The anti-photoaging effect of C-phycocyanin on ultraviolet B-irradiated BALB/c-nu mouse skin
Authors: Zhou Yali , Bai Renao , Huang Yifeng , Li Weina , Chen Jiana , Cheng Zhiyun , Wu Xunxun , Diao Yong
Published: August 2023

Introduction: C-phycocyanin (C-PC), a photosynthetic protein obtained from Spirulina, is regarded a highly promising commercially available biochemical. Numerous in vitro and in vivo studies have provided evidence of C-PC’s ability to mitigate the inflammatory response, alleviate oxidative stress, and facilitate wound healing. However, despite the existing knowledge regarding C-PC’s protective mechanism against cellular apoptosis induced by ultraviolet B (UVB) radiation, further in vivo experiments are needed to explore its anti-photoaging mechanism.

Methods: In this study, a UVB-induced skin photoaging model was established using BALB/c-nu mice, and the potential protective effects of topically administered c-PC were investigated by various molecular biology tools. In addition, a novel delivery system, C-PC nanodispersion, was developed to facilitate the transdermal delivery of C-PC.

Results: C- PC demonstrated significant anti-photoaging activities in the UVB-induced skin. The application of C-PC to the dorsal skin of the mice resulted in improved macroscopic characteristics, such as reduced sagging and coarse wrinkling, under UVB irradiation Histological analyses showed that C-PC treatment significantly decreased the symptoms of epidermal thickening, prevented dermal collagen fiber loosening, increased the hydroxyproline (Hyp) content and activities of antioxidant enzymes (such as superoxide dismutase, catalase, and glutathione peroxidase) in mouse skin, decreased malondialdehyde levels and expressions of inflammatory factors (interleukin-1α [IL-1α], IL-1β, IL-6, and tumor necrosis factor-α), reduced matrix metalloproteinase [MMP-3 and MMP-9] expressions, and inhibited the phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase, and p38 proteins in the mitogen-activated protein kinase family.

Discussion: By analyzing the results of the study, a new drug delivery system, C-PC nano-dispersion, was proposed, and the anti-photoaging effect of C-PC and its mechanism were investigated.
Microbial signatures of neonatal bacterial meningitis from multiple body sites
Authors: Hou Yuyang , Zhang Meng , Jiang Qiannan , Yang Yuping , Liu Jiang , Yuan Ke , Sun Zheng , Liu Xiuxiang
Published: August 2023

As a common central nervous system infection in newborns, neonatal bacterial meningitis (NBM) can seriously affect their health and growth. However, although metagenomic approaches are being applied in clinical diagnostic practice, there are some limitations for whole metagenome sequencing and amplicon sequencing in handling low microbial biomass samples. Through a newly developed ultra-sensitive metagenomic sequencing method named 2bRAD-M, we investigated the microbial signatures of central nervous system infections in neonates admitted to the neonatal intensive care unit. Particularly, we recruited a total of 23 neonates suspected of having NBM and collected their blood, cerebrospinal fluid, and skin samples for 2bRAD-M sequencing. Then we developed a novel decontamination method (Reads Level Decontamination, RLD) for 2bRAD-M by which we efficiently denoised the sequencing data and found some potential biomarkers that have significantly different relative abundance between 12 patients that were diagnosed as NBM and 11 Non-NBM based on their cerebrospinal fluid (CSF) examination results. Specifically, we discovered 11 and 8 potential biomarkers for NBM in blood and CSF separately and further identified 16 and 35 microbial species that highly correlated with the physiological indicators in blood and CSF. Our study not only provide microbiological evidence to aid in the diagnosis of NBM but also demonstrated the application of an ultra-sensitive metagenomic sequencing method in pathogenesis study.
Utility of clinical metagenomics in diagnosing malignancies in a cohort of patients with Epstein-Barr virus positivity
Authors: Song Jieyu , Zhu Kun , Wang Xiaojia , Yang Qingluan , Yu Shenglei , Zhang Yi , Fu Zhangfan , Wang Hongyu , Zhao Yuanhan , Lin Ke , Yuan Guanmin , Guo Jingxin , Shi Yingqi , Liu Chao , Ai Jingwen , Zhang Haocheng , Zhang Wenhong
Published: August 2023

Backgrounds

Differentiation between benign and malignant diseases in EBV-positive patients poses a significant challenge due to the lack of efficient diagnostic tools. Metagenomic Next-Generation Sequencing (mNGS) is commonly used to identify pathogens of patients with fevers of unknown-origin (FUO). Recent studies have extended the application of Next-Generation Sequencing (NGS) in identifying tumors in body fluids and cerebrospinal fluids. In light of these, we conducted this study to develop and apply metagenomic methods to validate their role in identifying EBV-associated malignant disease.

Methods

We enrolled 29 patients with positive EBV results in the cohort of FUO in the Department of Infectious Diseases of Huashan Hospital affiliated with Fudan University from 2018 to 2019. Upon enrollment, these patients were grouped for benign diseases, CAEBV, and malignant diseases according to their final diagnosis, and CNV analysis was retrospectively performed in 2022 using samples from 2018 to 2019.

Results

Among the 29 patients. 16 of them were diagnosed with benign diseases, 3 patients were diagnosed with CAEBV and 10 patients were with malignant diseases. 29 blood samples from 29 patients were tested for mNGS. Among all 10 patients with malignant diagnosis, CNV analysis suggested neoplasms in 9 patients. Of all 19 patients with benign or CAEBV diagnosis, 2 patients showed abnormal CNV results. The sensitivity and specificity of CNV analysis for the identification for tumors were 90% and 89.5%, separately.

Conclusions

The application of mNGS could assist in the identification of microbial infection and malignancies in EBV-related diseases. Our results demonstrate that CNV detection through mNGS is faster compared to conventional oncology tests. Moreover, the convenient collection of peripheral blood samples adds to the advantages of this approach.
A nuclear orthologue of the dNTP triphosphohydrolase SAMHD1 controls dNTP homeostasis and genomic stability in Trypanosoma brucei
Authors: Antequera-Parrilla Pablo , Castillo-Acosta Víctor M. , Bosch-Navarrete Cristina , Ruiz-Pérez Luis Miguel , González-Pacanowska Dolores
Published: August 2023

Maintenance of dNTPs pools in Trypanosoma brucei is dependent on both biosynthetic and degradation pathways that together ensure correct cellular homeostasis throughout the cell cycle which is essential for the preservation of genomic stability. Both the salvage and de novo pathways participate in the provision of pyrimidine dNTPs while purine dNTPs are made available solely through salvage. In order to identify enzymes involved in degradation here we have characterized the role of a trypanosomal SAMHD1 orthologue denominated TbHD82. Our results show that TbHD82 is a nuclear enzyme in both procyclic and bloodstream forms of T. brucei. Knockout forms exhibit a hypermutator phenotype, cell cycle perturbations and an activation of the DNA repair response. Furthermore, dNTP quantification of TbHD82 null mutant cells revealed perturbations in nucleotide metabolism with a substantial accumulation of dATP, dCTP and dTTP. We propose that this HD domain-containing protein present in kinetoplastids plays an essential role acting as a sentinel of genomic fidelity by modulating the unnecessary and detrimental accumulation of dNTPs.
Association between serum uric acid levels and peripheral artery disease in Chinese adults with hypertension
Authors: Han Fengyu , Yu Chao , Hu Feng , Zhou Wei , Wang Tao , Zhu Linjuan , Huang Xiao , Bao Huihui , Cheng Xiaoshu
Published: August 2023

Background

Higher serum uric acid (SUA) can cause gout, which is principally characterized by arthritis due to monosodium urate crystal deposition in the lower extremities. High levels of SUA have been linked to endothelial dysfunction, oxidative stress, and inflammation, all of which are involved in the pathogenesis of peripheral artery disease(PAD). To date, the relationship between SUA levels and PAD is still poorly understood.

Method

An analysis of 9,839 Chinese adults with essential hypertension from the ongoing China H-type Hypertension Registry Study was conducted in this cross-sectional study. Patients with an ABI ≤0.9 was diagnosed with PAD. Hyperuricemia was defined as SUA levels >420 mol/L in men and >360 mol/L in women. The association between SUA levels and PAD was evaluated using multivariable logistic regression models based on odds ratios (ORs) and their 95% confidence intervals (CIs).

Results

The enrolled subjects ranged in age from 27 to 93 years, with a mean age of 63.14 ± 8.99 years. The proportion of male patients was 46.22%, and the prevalence of hyperuricemia was 50.72%. In males, hyperuricemia was positively associated with the risk of PAD (adjusted OR per SD increase: 1.72, 95% CI 1.17 to 2.53, P =0.006). Males in the highest SUA tertile were significantly more likely to have PAD (adjusted OR: 2.63, 95% CI 1.42 to 4.86, P = 0.002; P for trend = 0.001). However, this positive relationship was not observed in females (adjusted OR: 1.29, 95% CI 0.77 to 2.17, P = 0.327; P for trend = 0.347).

Conclusion

According to this cross-sectional study, higher SUA levels were positively associated with PAD in male hypertensive patients, while this positive relationship disappeared in female participants.
Exploring stakeholders’ ecosystem services perceptions across Massachusetts Bays using deliberative valuation
Authors: Lyon-Mackie Jennifer , Vella Prassede , DiBona Pamela A. , Shehab-Sehovic Noora , Roche Samantha B. , Kreiley Allison I. , Mavrommati Georgia
Published: August 2023

Deliberative methods to assess ecosystem services values formalize community members’ and stakeholders’ involvement in decision-making related to natural resources management. This paper presents the methodological design and the application of a deliberative multicriteria evaluation (DMCE) method that combines the advantages of deliberation with structured decision-making to assess community-based values of four coastal ecosystem services (valued by indicators such as Total Nitrogen, Blue Carbon, Scallop Landings, Fish Abundance) and explore the spatial variability of group values along the Massachusetts coastline. We implemented four virtual deliberative workshops consisting of stakeholders from four Massachusetts Bays (MassBays) estuarine categorizations to collect quantitative and qualitative data. Quantitative data came from individual survey results and group preferences, while qualitative data were derived through the analysis of video recordings and transcripts of deliberations. Compared to previous studies, we combined quantitative and qualitative data by using applied thematic and co-occurrence analysis to identify themes of discussion during the deliberative process. Our results show that coastal stakeholders place a particular emphasis on access to clean water and services that directly support human wellbeing and provide direct economic benefits. Differences in the quantitative and qualitative results of these deliberative tasks between groups provide insight into the need for localized policymaking instead of solely regional or statewide management. Environmental managers and policymakers will utilize these insights to address local values and priorities as they work towards implementing habitat restoration efforts.
The dual role of cannabidiol on monocyte-derived dendritic cell differentiation and maturation
Authors: Pénzes Zsófia , Alimohammadi Shahrzad , Horváth Dorottya , Oláh Attila , Tóth Balázs István , Bácsi Attila , Szöllősi Attila Gábor
Published: August 2023

Introduction

Extracts and compounds isolated from hemp (Cannabis sativa) are increasingly gaining popularity in the treatment of a number of diseases, with topical formulations for dermatological conditions leading the way. Phytocannabinoids such as ( )-cannabidiol, ( )-cannabinol and ( )-Δ9-tetrahydrocannabivarin (CBD, CBN, and THCV, respectively), are present in variable amounts in the plant, and have been shown to have mostly anti-inflammatory effects both in vitro and in vivo, albeit dominantly in murine models. The role of phytocannabinoids in regulating responses of dendritic cells (DCs) remains unclear.

Methods

Our research aimed to investigate the effects of CBD, CBN, and THCV on human DCs differentiated from monocytes (moDCs). moDCs were treated with up to 10 μM of each phytocannabinoid, and their effects on viability, differentiation, and maturation were assessed both alone, and in conjunction with TLR agonists. The effects of CBD on cytokine production, T cell activation and polarization as well as the transcriptome of moDCs was also determined.

Results

Phytocannabinoids did not influence the viability of moDCs up to 10 μM, and only CBD had effects on maturational markers of moDCs, and neither compound influenced LPS-induced activation at 10 μM. Since only CBD had measurable effects on moDCs, in our subsequent experiments we tested the effect only of that pCB. On moDCs differentiated in the presence of CBD subsequent activation by LPS induced a markedly different, much more tolerogenic response. CBD-treated moDCs also produced significantly more interleukin (IL)-6, TNFα and, importantly, IL-10 in response to LPS, which shows a shift toward anti-inflammatory signaling, as well as a more robust secretory response in general. To rule out the possibility that these effects of CBD are specific to TLR4 signaling, we determined the effect of CBD on TLR7/8-induced maturation as well, and saw similar, although less marked responses. CBD-treated moDCs were also less efficient at activating naïve T cells after LPS stimulation, further supporting the tolerogenic effect of this phytocannabinoid on moDCs. Reactome pathway analysis showed an inflammatory response to LPS in moDCs, and to a lesser extent to CBD as well. In contrast CBD-treated moDCs responded to LPS with a shift towards a more tolerogenic phenotype, as IL-10 signaling was the most prominently induced pathway in this group.

Discussion

Our results show that CBD achieves an anti-inflammatory effect on adaptive immune responses only in the presence of an activating stimuli on moDCs by reprogramming cells during long-term treatment, and not through acute, short-term effects.
Eco-physiological response mechanism of Tamarix chinensis to soil water changes in coastal wetlands of the Yellow River Delta
Authors: Mao Peili , Lin Qingzhi , Pang Yuanxiang , Wang Kexin , Ni Ruiqiang , Han Xin , Cao Banghua
Published: August 2023

Elucidating the effect of soil moisture on the adaptation of dominant plants in coastal wetlands is important for predicting the evolution of vegetation in the region. In this paper, Tamarix chinensis, a dominant species in the Yellow River Delta, was used as the object to study the changes of its growth and physiological parameters with increasing soil salinity under different moisture conditions (normal watering, persistent drought and persistent waterlogging). Different salt stress (2‰, 5‰, 8‰, 12‰, 16‰, and 20‰) using pot experiments was also used to reveal the mechanism of soil moisture on its salt tolerance. The results showed that the relative growth rate between 5‰-8‰ soil salinity was the largest, and growth was significantly inhibited above 20‰. Among different moisture conditions, the difference in relative growth rate under normal watering and persistent drought were nonsignificant, while both were significantly lower than those under persistent waterlogging. With increasing soil salinity, relative water content and total chlorophyll content significantly decreased, and cell membrane permeability (malondialdehyde), sodium ion, osmoregulatory substances (proline, soluble protein), and protective enzyme activity (SOD) significantly increased, while changes in non-structural carbohydrates (NSC) were not significant. Compared with normal watering and persistent waterlogging, persistent drought had the lowest leaf relative water content, total chlorophyll content, and sodium ions, and the highest cell membrane permeability, osmoregulatory substances and protective enzyme activity. With increasing treatment time, the relative leaf water content and total chlorophyll content significantly decreased, and cell membrane permeability, osmoregulatory substances and protective enzyme activity increased more significantly than normal watering and persistent waterlogging. NSC increased under normal watering and persistent waterlogging, while significantly decreased under persistent drought. Correlation analysis showed that the relationships between sodium ions, total chlorophyll content and malondialdehyde were various under different moisture conditions. Under persistent drough, malondialdehyde was significantly positively correlated with relative conductivity, superoxide dismutase, proline, soluble protein and soluble sugar. Total chlorophyll content was the key indicator reflecting the salt and waterlogging tolerance of T. chinensis under normal watering and persistent waterlogging, while cell membrane damage was under persistent drought. In summary, T. chinensis has strong salt and waterlogging tolerance, but persistent drought with salt stress can have serious impacts on its growth and survival.
A new integrated framework for the identification of potential virus–drug associations
Authors: Qu Jia , Song Zihao , Cheng Xiaolong , Jiang Zhibin , Zhou Jie
Published: August 2023

Introduction

With the increasingly serious problem of antiviral drug resistance, drug repurposing offers a time-efficient and cost-effective way to find potential therapeutic agents for disease. Computational models have the ability to quickly predict potential reusable drug candidates to treat diseases.

Methods

In this study, two matrix decomposition-based methods, i.e., Matrix Decomposition with Heterogeneous Graph Inference (MDHGI) and Bounded Nuclear Norm Regularization (BNNR), were integrated to predict anti-viral drugs. Moreover, global leave-one-out cross-validation (LOOCV), local LOOCV, and 5-fold cross-validation were implemented to evaluate the performance of the proposed model based on datasets of DrugVirus that consist of 933 known associations between 175 drugs and 95 viruses.

Results

The results showed that the area under the receiver operating characteristics curve (AUC) of global LOOCV and local LOOCV are 0.9035 and 0.8786, respectively. The average AUC and the standard deviation of the 5-fold cross-validation for DrugVirus datasets are 0.8856 ± 0.0032. We further implemented cross-validation based on MDAD and aBiofilm, respectively, to evaluate the performance of the model. In particle, MDAD (aBiofilm) dataset contains 2,470 (2,884) known associations between 1,373 (1,470) drugs and 173 (140) microbes. In addition, two types of case studies were carried out further to verify the effectiveness of the model based on the DrugVirus and MDAD datasets. The results of the case studies supported the effectiveness of MHBVDA in identifying potential virus-drug associations as well as predicting potential drugs for new microbes.