bluuebunny/crossref_metadata_2025 huggingface dataset:
Enumerating Indigenous Arbuscular Mycorrhizal Fungi (AMF) Associated with Three Permanent Preservation Plots of Tropical Forests in Bangalore, Karnataka, India
Authors: Boya Saritha , Puttaswamy Poorvashree , Mahadevappa Nethravathi , Sharma Balasubramanya , Othumbamkat Remadevi
Published: March 2023

The establishment of Permanent Preservation Plots (PPPs) in natural forests has a signifi-cant role in assessing the impact of climate change on forests. To pursue long-term studies on cli-mate change, PPPs were established during the year 2016 in two major forest areas in Bangalore to conduct ecological studies to monitor the vegetation changes. One of the objectives of the study was to understand the drivers of diversity, such as soils, in terms of nutrients and physical and biological properties. The native tropical forest of Bangalore, which houses Bannerghatta National Park (BNP) on the outskirts, is relatively underexplored in terms of its microflora, particularly arbuscular my-corrhizal fungi (AMF). Hence, the present study was aimed at the quantitative estimation of arbus-cular mycorrhizal fungi (AMF) in the three 1-ha PPPs which were established in Bannerughatta National Park (BNP) and Doresanipalya Reserve Forest (DRF) as per the Centre for Tropical Forest Sciences (CTFS) protocol. In BNP, two plots were established, one in the Thalewood house area (mixed, moist, deciduous type) and the other in the Bugurikallu area (dry, deciduous type). In DRF, one plot was established in dry, deciduous vegetation. Each one-hectare plot (100 m × 100 m) was subdivided into twenty-five sub-plots (20 m × 20 m). Composite soil samples were collected during two seasons (dry and wet) and analyzed for AMF spore and available phosphorus (P) content. The results revealed the presence of AMF in all the three plots. Doresanipalya plo had the highest spore number, followed by the Bugurikallu plot and Thalewood house plot. The available phosphorous and AMF spore numbers showed correlations in all the three plots. Among the AMF spores, the Glomus species was found to dominate in all the three plots. The study shows that the dry, decidu-ous forests accommodated more AMF spores than the mixed, moist forests.
Big Data in Chronic Kidney Disease: Evolution or Revolution?
Authors: Kitcher Abbie , Ding UZhe , Wu Henry H. L. , Chinnadurai Rajkumar
Published: March 2023

Digital information storage capacity and biomedical technology advancements in recent decades have stimulated the maturity and popularization of “big data” in medicine. The value of utilizing big data as a diagnostic and prognostic tool has continued to rise given its potential to provide accurate and insightful predictions of future health events and probable outcomes for individuals and populations, which may aid early identification of disease and timely treatment interventions. Whilst the implementation of big data methods for this purpose is more well-established in specialties such as oncology, cardiology, ophthalmology, and dermatology, big data use in nephrology and specifically chronic kidney disease (CKD) remains relatively novel at present. Nevertheless, increased efforts in the application of big data in CKD have been observed over recent years, with aims to achieve a more personalized approach to treatment for individuals and improved CKD screening strategies for the general population. Considering recent developments, we provide a focused perspective on the current state of big data and its application in CKD and nephrology, with hope that its ongoing evolution and revolution will gradually identify more solutions to improve strategies for CKD prevention and optimize the care of patients with CKD.
Structural Analysis of Interactions between Epidermal Growth Factor Receptor (EGFR) Mutants and Their Inhibitors
Authors: Guo Yingzhe , Du Zeqian , Shi Ting
Published: March 2023

People’s lives and health are gravely threatened by non-small-cell lung cancer (NSCLC). Mutations in epidermal growth factor receptor (EGFR), a transmembrane receptor tyrosine kinase, are considered one of the causes of NSCLC. Tyrosine kinase inhibitors (TKIs) are typically used to treat patients with EGFR mutations. In this study, Gefitinib, a member of the first generation of TKIs, was used to treat an EGFR single-point mutation (single mutant, SM). Patients harboring additional T790M mutations in the kinase domain of the EGFR were resistant to Gefitinib. Then, the L858R/T790M double mutation (double mutant, DM) was treated with the second generation of TKIs, such as Afatinib. Here, we constructed four computational models to uncover the structural basis between EGFR mutants (SM and DM) and corresponding inhibitors (Gefitinib and Afatinib). The binding energy in the G-SM (representing Gefitinib in complex with SM) system was larger than that in the G-DM (Representing Gefitinib in complex with DM) system. Gefitinib’s affinity with L792 and M793 was drastically reduced by the longer side chain of M790 in the G-DM system, which pushed Gefitinib outside of the pocket. Additionally, the A-DM system’s binding energy was higher than the G-DM system’s. Afatinib, unlike Gefitinib, induced the P-loop region to move downwards to decrease the pocket entrance size to accommodate Afatinib properly and stably in the A-DM (Afatinib in complex with DM) system. These results uncover the details of interactions between EGFR and its inhibitors and shed light on the design of new tyrosine kinase inhibitors.
Research Progress of Tungsten Oxide-Based Catalysts in Photocatalytic Reactions
Authors: Ni Zenan , Wang Qiuwen , Guo Yuxin , Liu Huimin , Zhang Qijian
Published: March 2023

Photocatalysis technology is a potential solution to solve the problem of environmental pollution and energy shortage, but its wide application is limited by the low efficiency of solar energy conversion. As a non-toxic and inexpensive n-type semiconductor, WO3 can absorb approximately 12% of sunlight which is considered one of the most attractive photocatalytic candidates. However, the narrow light absorption range and the high recombination rate of photogenerated electrons and holes restrict the further development of WO3-based catalysts. Herein, the studies on preparation and modification methods such as doping element, regulating defects and constructing heterojunctions to enlarge the range of excitation light to the visible region and slow down the recombination of carriers on WO3-based catalysts so as to improve their photocatalytic performance are reviewed. The mechanism and application of WO3-based catalysts in the dissociation of water, the degradation of organic pollutants, as well as the hydrogen reduction of N2 and CO2 are emphatically investigated and discussed. It is clear that WO3-based catalysts will play a positive role in the field of future photocatalysis. This paper could also provide guidance for the rational design of other metallic oxide (MOx) catalysts for the increasing conversion efficiency of solar energy.
Renal Cell Carcinoma Unclassified with Medullary Phenotype in a Patient with Neurofibromatosis Type 2
Authors: Sarkar Sanila , Throckmorton Whitney , Bingham Racheal , Msaouel Pavlos , Genovese Giannicola , Slopis John , Rao Priya , Sadighi Zsila , Herzog Cynthia E.
Published: March 2023

We present, to our knowledge, the first reported case of germline neurofibromatosis Type 2 (NF2) associated with renal cell carcinoma unclassified with medullary phenotype (RCCU-MP) with somatic loss by immunohistochemistry of the SMARCB1 tumor suppressor gene located centromeric to NF2 on chromosome 22q. Our patient is a 15-year-old with germline neurofibromatosis Type 2 (NF2) confirmed by pathogenic mutation of c.-854-??46+??deletion. Her NF2 history is positive for a right optic nerve sheath meningioma, CNIII schwannoma requiring radiation therapy and post gross total resection of right frontotemporal anaplastic meningioma followed by radiation. At age 15 she developed new onset weight loss and abdominal pain due to RCCU-MP. Hemoglobin electrophoresis was negative for sickle hemoglobinopathy. Chemotherapy (cisplatin, gemcitabine and paclitaxel) was initiated followed by radical resection. Given the unique renal pathology of a high grade malignancy with loss of SMARCB1 expression via immunohistochemistry, and history of meningioma with MLH1 loss of expression and retained expression of PMS2, MSH2 and MSH6, further germline genetic testing was sent for SMARCB1 and mismatch repair syndromes. Germline testing was negative for mutation in SMARCB1. Therefore, this is the first reported case of RCCU-MP associated with germline NF2 mutation. This suggests the importance of closer surveillance in the adolescent and young adult population with NF2 with any suspicious findings of malignancy outside of the usual scope of practice with NF2.
Persisting Deficits in Health-Related Quality of Life of Colorectal Cancer Survivors 14–24 Years Post-Diagnosis: A Population-Based Study
Authors: Thong Melissa S. Y. , Doege Daniela , Weißer Linda , Koch-Gallenkamp Lena , Jansen Lina , Bertram Heike , Eberle Andrea , Holleczek Bernd , Nennecke Alice , Waldmann Annika , Zeissig Sylke Ruth , Brenner Hermann , Arndt Volker
Published: March 2023

(1) Background: The health-related quality of life (HRQOL) of colorectal cancer (CRC) survivors >10 years post-diagnosis is understudied. We aimed to compare the HRQOL of CRC survivors 14–24 years post-diagnosis to that of age- and sex-matched non-cancer controls, stratified by demographic and clinical factors. (2) Methods: We used data from 506 long-term CRC survivors and 1489 controls recruited from German population-based multi-regional studies. HRQOL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Core-30 (EORTC QLQ-C30) questionnaire. We estimated differences in the HRQOL of CRC survivors and controls with multiple regression, adjusted for age at survey, sex, and education, where appropriate. (3) Results: CRC survivors reported poorer social functioning but better health status/QOL than controls. CRC survivors, in general, had higher levels of symptom burden, and in particular diarrhea and constipation, regardless of demographic or clinical factors. In stratified analyses, HRQOL differed by age, sex, cancer type, and having a permanent stoma. (4) Conclusions: Although CRC survivors may have a comparable health status/QOL to controls 14–24 years after diagnosis, they still live with persistent bowel dysfunction that can negatively impact aspects of functioning. Healthcare providers should provide timely and adapted follow-up care to ameliorate potential long-term suffering.
Fault-Tolerant Control for Carrier-Based UAV Based on Sliding Mode Method
Authors: Yao Zhuoer , Kan Zi , Zhen Chong , Shao Haoyuan , Li Daochun
Published: March 2023

To enable a carrier-based unmanned aerial vehicle (UAV) to track the desired glide trajectory and safely land on the deck with the presence of system faults, this paper proposes a neural network-based adaptive sliding mode fault-tolerant control (NASFTC) method. Firstly, the dynamic model of the carrier -based UAV, the actuator fault model, the additional unknown fault model, and the control framework of the automatic carrier landing system (ACLS) were developed. Subsequently, controllers for both longitudinal and lateral channels were designed by using the NASFTC method. The controller consists of three parts: the adaptive laws for compensating the actuator faults, the RBF neural network for compensating the additional unknown faults, and the sliding mode method for ensuring overall trajectory tracking. Then, the Lyapunov function theorem was applied to carry out the stability analysis. Finally, comparative simulations under three different scenarios were conducted. The comparative results show the effectiveness of the proposed NASFTC method, which has fault-tolerant ability and can successfully control the aircraft to execute carrier landing task regardless of the actuator partial loss fault and the additional unknown fault.
Optomechanics-Based Quantum Estimation Theory for Collapse Models
Authors: Marchese Marta Maria , Belenchia Alessio , Paternostro Mauro
Published: March 2023

We make use of the powerful formalism of quantum parameter estimation to assess the characteristic rates of a continuous spontaneous localization (CSL) model affecting the motion of a massive mechanical system. We show that a study performed in non-equilibrium conditions unveils the advantages provided by the use of genuinely quantum resources—such as quantum correlations—in estimating the CSL-induced diffusion rate. In stationary conditions, instead, the gap between quantum performance and a classical scheme disappears. Our investigation contributes to the ongoing effort aimed at identifying suitable conditions for the experimental assessment of collapse models.
Evaluating the Effect of the Communication Link of the Relays on the Operation Time of the Protection System
Authors: Azari Aliakbar , Noghabi Abass Saberi , Zishan Farhad , Montoya Oscar Danilo , Molina-Cabrera Alexander
Published: March 2023

In case of an error in the power system, it is the duty of the protection relays to isolate the faulty part from the rest of the system as soon as possible. Overcurrent and distance relays are usually used to protect the transmission and super distribution systems. The optimum coordination of these relays is very important. In this article, communication links are used to improve the optimal coordination of overcurrent and distance relays. In the proposed plan, the overcurrent relays on both sides of the line are equipped with a communication link for immediate action in the event of an error. Using this communication link, the complete coverage of the line is also provided by distance relays. The number and place of installation of the communication link greatly affect the operation time of overcurrent relays and the distance and coordination between them. The coordination problem is formulated by considering the location and number of communication links, and to solve it, the combined optimization algorithm of genetics and linear programming will be used. With the help of the genetic algorithm, the location and setting of the second zone of the distance relay, and by using the linear programming algorithm, the setting of the overcurrent relays is determined. The proposed method has been tested on the IEEE 14-bus (the simulation in MATLAB software) network and its results examined, and it will be seen how much the existence of a communication link can improve the performance time of the protection system.
A Physics-Based Modelling and Control of Greenhouse System Air Temperature Aided by IoT Technology
Authors: Faniyi Beatrice , Luo Zhenhua
Published: March 2023

The need to reduce energy consumption in greenhouse production has grown. Thermal heating demand alone accounts for 80% of conventional greenhouse energy consumption; this significantly reduces production profit. Since microclimate affects crop metabolic processes and output, it is essential to monitor and control it to achieve both quantity and quality production with minimum energy consumption for maximum profit. The Internet of Things (IoT) is an evolving technology for monitoring and controlling environments that have recently been adopted to boost greenhouse efficiency in many applications by integrating hardware and software solutions; therefore, its adoption is thus critical in enabling greenhouse energy consumption minimisation. The first objective of this study is to improve and validate a greenhouse dynamic air temperature model required to simulate or predict indoor temperature. To achieve the first objective, therefore, an existing model was enhanced and a closed loop test experimental data from the IoT cloud-based control system platform deployed in the prototype greenhouse built in Cranfield University was used to validate the model using an optimisation-based model fitting approach. The second goal is to control the greenhouse air temperature in simulation using relatively simple PI and on-off control strategies to maintain the grower’s desired setpoint irrespective of the inevitable disturbances and to verify the potential of the controllers in minimising the total energy input to the greenhouse. For the second objective, the simulation results showed that the two controllers maintained the desired setpoint; however, the on-off strategy retained a sustainable oscillation, and the tuned PI effectively maintained the desired temperature, although the average energy used by the controllers is the same.
Creation, Analysis and Evaluation of AnnoMI, a Dataset of Expert-Annotated Counselling Dialogues
Authors: Wu Zixiu , Balloccu Simone , Kumar Vivek , Helaoui Rim , Reforgiato Recupero Diego , Riboni Daniele
Published: March 2023

Research on the analysis of counselling conversations through natural language processing methods has seen remarkable growth in recent years. However, the potential of this field is still greatly limited by the lack of access to publicly available therapy dialogues, especially those with expert annotations, but it has been alleviated thanks to the recent release of AnnoMI, the first publicly and freely available conversation dataset of 133 faithfully transcribed and expert-annotated demonstrations of high- and low-quality motivational interviewing (MI)—an effective therapy strategy that evokes client motivation for positive change. In this work, we introduce new expert-annotated utterance attributes to AnnoMI and describe the entire data collection process in more detail, including dialogue source selection, transcription, annotation, and post-processing. Based on the expert annotations on key MI aspects, we carry out thorough analyses of AnnoMI with respect to counselling-related properties on the utterance, conversation, and corpus levels. Furthermore, we introduce utterance-level prediction tasks with potential real-world impacts and build baseline models. Finally, we examine the performance of the models on dialogues of different topics and probe the generalisability of the models to unseen topics.
Numerical Study of the Effects of Surface Tension and Initial Volume Fraction on Gas-Liquid-Foam Three-Phase Flow Separation Process
Authors: Tan TianTian , Zhang Jiaqing , Hu Junjie , Zhang Jianghong , Sun Gang , Li Bo , Guo Yi
Published: March 2023

Since it is low in cost and low in toxicity and has good biodegradability, gas-liquid-foam three-phase flow has been widely used in industrial fire protection. Due to the different characteristics of gas, liquid, and foam, liquid precipitation is liable to occur under static conditions, resulting in unstable performance of the mixture. To improve fire extinguishing efficiency, it is of great significance to study the separation process of gas-liquid-foam. In the present study, the effects of the surface tension (range from 0.04 to 0.07) and initial liquid volume fraction (range from 0.2 to 0.5) on the gas-liquid-foam separation process are investigated with the numerical tool Fluent. The liquid volume fraction is mainly influenced by two inverse effects: (a) the transformation of liquid into foam, and (b) the liquid drainage and bursting of foam. In the separation process, the volume fraction of small foam decreases monotonically while the volume fraction of medium and large foam increases slightly. Since the volume fraction of small foam is much greater than medium and large foam and its bursting process is dominant, the liquid volume fraction presents a monotonic increasing trend. The volume of the separated liquid increases almost linearly with time at various surface tensions and initial volume fractions, and the increase rate is about 0.004. In the range of the surface tension examined, the separation process is insensitive to the surface tension, resulting in almost the same drainage time. On the other hand, the separation process depends on the initial liquid volume fraction non-monotonically; namely, when the initial volume fraction is small, with the increase of the initial volume fraction, the liquid is more easily separated from the mixture, and when the initial volume fraction is over a critical value (about 0.4), the separation process is decelerated.
Mechanism for the Magnetorheological Effect of Nanocomposite Hydrogels with Magnetite Microparticles
Authors: Selzer Lukas , Odenbach Stefan
Published: March 2023

In a previous study, we presented an empirical law for the magnetorheological effect of nanocomposite hydrogels with magnetite microparticles derived from rheological data. In order to understand the underlying processes, we employ computed tomography for structure analysis. This allows the evaluation of the translational and rotational movement of the magnetic particles. Gels with 10% and 3.0% magnetic particle mass content are investigated at three degrees of swelling and at different magnetic flux densities in steady states by means of computed tomography. Since a temperature-controlled sample-chamber is difficult to implement in a tomographic setup, salt is used to deswell the gels instead. Based on the findings of the particle movement, we propose a mechanism using an energy-based approach. This leads to a theoretical law that shows the same scaling behavior as the previously found empirical law.
The Development of a Polysaccharide-Based Hydrogel Encapsulating Tobramycin-Loaded Gelatine Microspheres as an Antibacterial System
Authors: Shi Mingsheng , Xu Yongmeng , Li Shuai , Wang Lifeng , Gu Junyao , Zhang Yi-Xuan
Published: March 2023

Bacterial infection contributes to the bioburden of wounds, which is an essential factor in determining whether a wound can heal. Wound dressings with antibacterial properties that can promote wound-healing are highly desired for the treatment of chronic wound infections. Herein, we fabricated a simple polysaccharide-based hydrogel dressing encapsulating tobramycin-loaded gelatine microspheres with good antibacterial activity and biocompatibility. We first synthesised long-chain quaternary ammonium salts (QAS) by the reaction of tertiary amines with epichlorohydrin. The amino groups of carboxymethyl chitosan were then conjugated with QAS through the ring-opening reaction and QAS-modified chitosan (CMCS) was obtained. The antibacterial analysis showed that both QAS and CMCS could kill E. coli and S. aureus at relatively low concentrations. QAS with 16 carbon atoms has a MIC of 16 μg/mL for E. coli and 2 μg/mL for S. aureus. A series of formulations of tobramycin-loaded gelatine microspheres (TOB-G) were generated and the best formulation was selected by comparing the characters of the microspheres. The microsphere fabricated by 0.1 mL GTA was selected as the optimal candidate. We then used CMCS, TOB-G, and sodium alginate (SA) to prepare physically crosslinking hydrogels using CaCl2 and investigated the mechanical properties, antibacterial activity, and biocompatibility of the hydrogels. In summary, the hydrogel dressing we produced can be used as an ideal alternative for the management of bacteria-infected wounds.
The Perspective of mHealth in the Self-Assessment of the Parkinson’s Disease. Comment on Kalafati et al. Testing of Motor Coordination in Degenerative Neurological Diseases. Healthcare 2022, 10, 1948
Authors: Giansanti Daniele
Published: March 2023

Regarding the research article “Maria Kalafati, Athanasios Kakarountas and Elisabeth Chroni, Testing of Motor Coordination in Degenerative Neurological Diseases”, published in Healthcare [...]
Quantitative Evaluation of Spatial Accessibility of Various Urban Medical Services Based on Big Data of Outpatient Appointments
Authors: Sui Jinling , Zhang Guoqin , Lin Tao , Hamm Nicholas A. S. , Li Chunlin , Wu Xian , Hu Kaiqun
Published: March 2023

Equity of urban medical services affects human health and well-being in cities and is important in building ‘just’ cities. We carried out a quantitative analysis of the spatial accessibility of medical services considering the diverse demands of people of different ages, using outpatient appointment big data and refining the two-step floating catchment area (2SFCA) method. We used the traditional 2SFCA method to evaluate the overall spatial accessibility of medical services of 504 communities in Xiamen city, considering the total population and the supply of medical resources. Approximately half the communities had good access to medical services. The communities with high accessibility were mainly on Xiamen Island, and those with low accessibility were further from the central city. The refined 2SFCA method showed a more diverse and complex spatial distribution of accessibility to medical services. Overall, 209 communities had high accessibility to internal medicine services, 133 to surgery services, 50 to gynecology and obstetrics services, and 18 to pediatric services. The traditional method may over-evaluate or under-evaluate the accessibility of different types of medical services for most communities compared with the refined evaluation method. Our study can provide more precise information on urban medical service spatial accessibility to support just city development and design.
The Role of Traffic Volume on Sound Pressure Level Reduction before and during COVID-19 Lockdown Measures—A Case Study in Bochum, Germany
Authors: Hemker Falk , Haselhoff Timo , Brunner Susanne , Lawrence Bryce T. , Ickstadt Katja , Moebus Susanne
Published: March 2023

During the SARS-CoV-2 pandemic, sound pressure levels (SPL) decreased because of lockdown measures all over the world. This study aims to describe SPL changes over varying lockdown measure timeframes and estimate the role of traffic on SPL variations. To account for different COVID-19 lockdown measures, the timeframe during the pandemic was segmented into four phases. To analyze the association between a-weighted decibels (dB(A)) and lockdown phases relative to the pre-lockdown timeframe, we calculated a linear mixed model, using 36,710 h of recording time. Regression coefficients depicting SPL changes were compared, while the model was subsequently adjusted for wind speed, rainfall, and traffic volume. The relative adjusted reduction of during pandemic phases to pre-pandemic levels ranged from −0.99 dB(A) (CI: −1.45; −0.53) to −0.25 dB(A) (CI: −0.96; 0.46). After controlling for traffic volume, we observed little to no reduction (−0.16 dB(A) (CI: −0.77; 0.45)) and even an increase of 0.75 dB(A) (CI: 0.18; 1.31) during the different lockdown phases. These results showcase the major role of traffic regarding the observed reduction. The findings can be useful in assessing measures to decrease noise pollution for necessary future population-based prevention.
Vitality Revisited: The Evolving Concept of Flourishing and Its Relevance to Personal and Public Health
Authors: Logan Alan C. , Berman Brian M. , Prescott Susan L.
Published: March 2023

Human flourishing, the state of optimal functioning and well-being across all aspects of an individual’s life, has been a topic of philosophical and theological discussion for centuries. In the mid-20th century, social psychologists and health scientists began exploring the concept of flourishing in the context of health and high-level wellness. However, it is only in recent years, in part due to the USD 43 million Global Flourishing Study including 22 countries, that flourishing has entered the mainstream discourse. Here, we explore this history and the rapid acceleration of research into human flourishing, defined as “the relative attainment of a state in which all aspects of a person’s life are good” by the Harvard University’s Flourishing Program. We also explore the construct of “vitality”, which refers to a sense of aliveness, energy, and motivation; we contend that this has been neglected in the flourishing movement. We explore why incorporating measures of vitality, together with a broader biopsychosocial approach, considers all dimensions of the environment across time (the total exposome), which will greatly advance research, policies, and actions to achieve human flourishing.
Effect of Gliding Arc Plasma Jet on the Mycobiota and Deoxynivalenol Levels in Naturally Contaminated Barley Grains
Authors: Chiappim William , de Paula Bernardes Vanessa , Almeida Naara Aparecida , Pereira Viviane Lopes , Bragotto Adriana Pavesi Arisseto , Cerqueira Maristela Barnes Rodrigues , Furlong Eliana Badiale , Pessoa Rodrigo , Rocha Liliana Oliveira
Published: March 2023

Fusarium graminearum and Fusarium meridionale are primary contaminants of barley, capable of producing several mycotoxins, mainly type B trichothecenes and zearalenone. Cold plasma decontamination has been gaining prominence, seeking to control the fungal and mycotoxin contamination of food and feed and to improve product quality. To reach this objective, the present study was divided into two parts. In the first part, F. meridionale and F. graminearum strains were exposed to gliding arc plasma jet (GAPJ). Cell viability tests showed the inactivation of F. meridionale after 15-min treatment, whereas F. graminearum showed to be resistant. In the second part, barley grains were treated by GAPJ for 10, 20, and 30 min, demonstrating a reduction of about 2 log CFU/g of the barley’s mycobiota, composed of yeasts, strains belonging to the F. graminearum species complex, Alternaria, and Aspergillus. A decrease in DON levels (up to 89%) was observed after exposure for 20 min. However, an increase in the toxin Deoxynivalenol-3-glucoside (D3G) was observed in barley grains, indicating a conversion of DON to D3G.
Recruitment of Adolescent Young Carers to a Psychosocial Support Intervention Study in Six European Countries: Lessons Learned from the ME-WE Project
Authors: Barbabella Francesco , Magnusson Lennart , Boccaletti Licia , Casu Giulia , Hlebec Valentina , Bolko Irena , Lewis Feylyn , Hoefman Renske , Brolin Rosita , Santini Sara , Socci Marco , D’Amen Barbara , de Jong Yvonne , Bouwman Tamara , de Jong Nynke , Leu Agnes , Phelps Daniel , Guggiari Elena , Wirth Alexandra , Morgan Vicky , Becker Saul , Hanson Elizabeth
Published: March 2023

Young carers provide a substantial amount of care to family members and support to friends, yet their situation has not been actively addressed in research and policy in many European countries or indeed globally. Awareness of their situation by professionals and among children and young carers themselves remains low overall. Thus, young carers remain a largely hidden group within society. This study reports and analyses the recruitment process in a multi-centre intervention study offering psychosocial support to adolescent young carers (AYCs) aged 15–17 years. A cluster-randomised controlled trial was designed, with recruitment taking place in Italy, the Netherlands, Slovenia, Sweden, Switzerland and the United Kingdom exploiting various channels, including partnerships with schools, health and social services and carers organisations. In total, 478 AYCs were recruited and, after screening failures, withdrawals and initial dropouts, 217 were enrolled and started the intervention. Challenges encountered in reaching, recruiting and retaining AYCs included low levels of awareness among AYCs, a low willingness to participate in study activities, uncertainty about the prevalence of AYCs, a limited school capacity to support the recruitment; COVID-19 spreading in 2020–2021 and related restrictions. Based on this experience, recommendations are put forward for how to better engage AYCs in research.
COVID-19 Testing, Vaccine Perceptions, and Trust among Hispanics Residing in an Underserved Community
Authors: Frietze Gabriel A. , Mancera Bibiana M. , Kenney Michael J.
Published: March 2023

The Borderplex region has been profoundly impacted by the COVID-19 pandemic. Borderplex residents live in low socioeconomic (SES) neighborhoods and lack access to COVID-19 testing. The purpose of this study was two-fold: first, to implement a COVID-19 testing program in the Borderplex region to increase the number of residents tested for COVID-19, and second, to administer a community survey to identify trusted sources of COVID-19 information and factors associated with COVID-19 vaccine uptake. A total of 4071 community members were tested for COVID-19, and 502 participants completed the survey. COVID-19 testing resulted in 66.8% (n = 2718) positive cases. The community survey revealed that the most trusted sources of COVID-19 information were doctors or health care providers (67.7%), government websites (e.g., CDC, FDA, etc.) (41.8%), and the World Health Organization (37.8%). Logistic regression models revealed several statistically significant predictors of COVID-19 vaccine uptake such as having a trusted doctor or health care provider, perceiving the COVID-19 vaccine to be effective, and perceiving that the COVID-19 vaccine does not cause side-effects. Findings from the current study highlight the need for utilizing an integrated, multifactorial approach to increase COVID-19 testing and to identify factors associated with COVID-19 vaccine uptake in underserved communities.
Understanding Attentional Functioning in Adult Attention Deficit Hyperactivity Disorder—Could This Improve Diagnostic Specificity?
Authors: Babajanyan Diana , Freame Leanne , Steele Ray , Poulton Alison
Published: March 2023

The diagnostic criteria for attention deficit hyperactivity disorder (ADHD) reflect the behavioural and functional outcomes of cognitive processes. Historically they have been based on external observations and lack specificity: clinical cohorts of children meeting diagnostic criteria show that around 40% may also meet diagnostic criteria for oppositional defiant disorder (ODD). We have proposed a clinical model to explain this: the Mental Effort Reward Imbalances model of ADHD (MERIM). This model views the lower levels of task completion that underlie several of the diagnostic criteria for ADHD as being due to a summation of deficits in executive functioning and reward processing. The subjective experience of inadequate reward from task completion may explain the reduced motivation, negativity, and oppositional attitude associated with ODD. The hypothesis for this study is that descriptions of affected individuals’ attentional characteristics could be more specific for the executive functioning deficits associated with ADHD than the current symptom-based approaches. To test whether this might be usable in practice, we conducted a workshop that aimed to characterise in depth the patterns of attention experienced by adults with ADHD and how they impact functioning. Three main patterns were described: (1) complete lapses in attention; (2) partial attention to a task; (3) attending to multiple tasks and distractions, either simultaneously or in rapid sequence. All of these resulted in reduced productivity. They also described strategies for managing their attention deficits. Some people used distractions positively, to stimulate the mind to remain active and engaged rather than losing focus. Multi-tasking could also achieve this by providing higher levels of stimulation, however, the stimulation could itself become a distraction. Interest or stress might maintain engagement; extremes could sometimes lead to hyperfocusing, which was typically infrequent but could be highly productive. Focusing on executive functions may improve diagnostic sensitivity, as the current criteria fail to identify people who function adequately due to their use of strategies that mitigate the effects of their attentional deficits. Such people may present with secondary depression or anxiety rather than clear, behavioural symptoms of ADHD. With further development, the approach described in this paper may provide a more simple and fundamental way of recognising ADHD within the community. In the longer term, focusing more specifically on executive functions may provide cohorts with a ‘purer’ form of ADHD for scientific study.
Quality of Life, Physical and Mental Health, and Economic Evaluation of Family Caregivers of Chronic Dependent Children: INFAPRINT Cohort Study Protocol
Authors: León-Campos Álvaro , García-Mayor Silvia , Martí-García Celia , Morilla-Herrera Juan Carlos , Morales-Asencio José Miguel , Lupiáñez-Pérez Inmaculada , Pérez-Ardanaz Bibiana , Cuevas Fernandez-Gallego Magdalena
Published: March 2023

Background: Caregivers for children with complex chronic illnesses may experience emotional and physical strain, especially as concerns attention overload and the perceptions of their own psychosocial situation. These concerns, together with the additional financial cost and the socioeconomic inequalities that arise from caregiving responsibilities, create major challenges to the health status of this population group. Methods: A prospective analytical longitudinal study will be conducted, based on an exposed cohort of adult caregivers (parents or guardians) for children with complex chronic processes, to evaluate the impact of caregiving responsibilities on the health status of this population group. Conclusions and implications: The practical implications of this study are of great significance for clinical practice. The results of this study have the potential to inform the decision-making process in the healthcare sector and guide future research initiatives. The findings of this study will provide crucial insights into the health-related quality of life of caregivers of children with complex chronic illnesses, which will be valuable in addressing the challenges faced by this population group. This information can be used to improve the availability and accessibility of appropriate health services and to facilitate the development of more equitable health outcomes for caregivers of children with complex chronic illnesses. By highlighting the extent to which this population is affected both physically and mentally, the study can contribute to the development of clinical practices that prioritize the health and well-being of caregivers in the care of children with complex chronic illnesses.
Clinical Features to Predict the Use of a sEMG Wearable Device (REMO®) for Hand Motor Training of Stroke Patients: A Cross-Sectional Cohort Study
Authors: Pregnolato Giorgia , Rimini Daniele , Baldan Francesca , Maistrello Lorenza , Salvalaggio Silvia , Celadon Nicolò , Ariano Paolo , Pirri Candido Fabrizio , Turolla Andrea
Published: March 2023

After stroke, upper limb motor impairment is one of the most common consequences that compromises the level of the autonomy of patients. In a neurorehabilitation setting, the implementation of wearable sensors provides new possibilities for enhancing hand motor recovery. In our study, we tested an innovative wearable (REMO®) that detected the residual surface-electromyography of forearm muscles to control a rehabilitative PC interface. The aim of this study was to define the clinical features of stroke survivors able to perform ten, five, or no hand movements for rehabilitation training. 117 stroke patients were tested: 65% of patients were able to control ten movements, 19% of patients could control nine to one movement, and 16% could control no movements. Results indicated that mild upper limb motor impairment (Fugl-Meyer Upper Extremity ≥ 18 points) predicted the control of ten movements and no flexor carpi muscle spasticity predicted the control of five movements. Finally, severe impairment of upper limb motor function (Fugl-Meyer Upper Extremity > 10 points) combined with no pain and no restrictions of upper limb joints predicted the control of at least one movement. In conclusion, the residual motor function, pain and joints restriction, and spasticity at the upper limb are the most important clinical features to use for a wearable REMO® for hand rehabilitation training.
“I Crave a Blunt, I Don’t Crave a Cigarillo”: A Focus Group Study on Perceptions of Nicotine and Addiction among US Adults Who Currently Smoke Little Cigars or Cigarillos
Authors: Hackworth Emily E. , Ntansah Charity A. , Henderson Katherine C. , Pei Di , Reynolds Reed M. , Duong Hue Trong , Yang Bo , Ashley David L. , Thrasher James F. , Popova Lucy
Published: March 2023

While the US Food and Drug Administration (FDA)’s proposal to reduce the nicotine content in cigarettes is gaining traction, it is still undetermined whether the policy will also include other combustible tobacco products, such as little cigars and cigarillos (LCCs), and how such a policy should be communicated given the patterns of use and perceptions around LCCs. This study examined perceptions of nicotine and addiction related to LCC use and involved data collection from eight semi-structured virtual focus groups conducted in Summer 2021 in the US. Participants were adults who reported past-30-day use of LCCs, consisting of African American males (n = 9), African American females (n = 9), white males (n = 14), and white females (n = 11). Participants discussed their perceptions of nicotine and addiction in general and in relation to LCC use. Inductive thematic analysis of transcripts was conducted. Differences across race and sex groups were examined. Participants did not consider nicotine to be a characterizing feature of LCCs; rather, they generally associated nicotine with cigarettes. Participants’ views of nicotine and addiction related to LCCs were discussed along four dimensions: context of use, frequency of use, the presence of cravings, and whether a product is modified (e.g., by adding marijuana). Social and infrequent use, a lack of cravings, and the use of LCCs for marijuana were considered indicative of a lack of addiction and reasons not to be concerned about nicotine in LCCs. Because perceptions of nicotine and addiction related to LCCs differ from those of cigarettes, communications about a reduced nicotine policy that includes LCCs should consider these differences to ensure the policy is understood by people who currently use LCCs and to prevent people who use cigarettes from switching to LCCs.
The Effect of Quinolones on Common Duckweed Lemna minor L., a Hydrophyte Bioindicator of Environmental Pollution
Authors: Sikorski Łukasz , Bęś Agnieszka , Warmiński Kazimierz
Published: March 2023

Plant growth and the development of morphological traits in plants are inhibited under exposure to pharmaceuticals that are present in soil and water. The present study revealed that moxifloxacin (MOXI), nalidixic acid (NAL), levofloxacin (LVF) and pefloxacin (PEF) at concentrations of >0.29, >0.48, >0.62 and >1.45 mg × L−1, respectively, inhibited the growth (Ir) of duckweed plants and decreased their yield (Iy). In the current study, none of the tested quinolones (QNs) at any of the examined concentrations were lethal for common duckweed plants. However, at the highest concentration (12.8 mg × L−1), LVF increased Ir and Iy values by 82% on average and increased the values of NAL, PEF and MOXI by 62% on average. All tested QNs led to the loss of assimilation pigments. In consequence, all QNs, except for LVF, induced changes in chlorophyll fluorescence (Fv/Fm), without any effect on phaeophytinization quotient (PQ) values. The uptake of NAL, MOXI, LVF by Lemna minor during the 7-day chronic toxicity test was directly proportional to drug concentrations in the growth medium. Nalidixic acid was absorbed in the largest quantities, whereas in the group of fluoroquinolones (FQNs), MOXI, LVF and PEF were less effectively absorbed by common duckweed. This study demonstrated that biosorption by L. minor occurs regardless of the plants’ condition. These findings indicate that L. minor can be used as an effective biological method to remove QNs from wastewater and water and that biosorption should be a mandatory process in conventional water and wastewater treatment.
Coupling Evaluation and Spatial–Temporal Evolution of Land Ecosystem Services and Economic–Social Development in a City Group: The Case Study of the Chengdu–Chongqing City Group
Authors: Zhong Qikang , Li Zhe , He Yujing
Published: March 2023

The Chengdu–Chongqing city group (CCCG) is one of the regions with acute human–land conflicts in China at present. The current rapid development of CCCG has caused a large negative impact on regional land ecosystem services. Land ecosystem is the basis of economic development. Reasonable economic development is also the inherent requirement of land ecosystem and an important support for land ecosystem protection. Promoting the coordinated development of the economy and land ecosystems is a prerequisite for this city group to achieve ecological protection and high-quality development. Taking CCCG as an example, this paper constructs a coupling evaluation model of economic–social development and land ecosystem service by using the entropy weight method, coupling coordination degree model, gravity center model, and standard deviation ellipse model, and explores the coupling coordination degree and spatial–temporal evolution rule of the above two systems. The study found that, from 2005 to 2020, the overall economic–social development of the CCCG showed an upward trend with a regular pattern of a ‘High in the east and west, low in the central’, and the ‘dual-core’ spatial structure with Chengdu and Chongqing as the core ; the overall performance of land ecosystem services had a gentle slope downward trend with a ‘U’-shaped spatial pattern of “high around and low in the middle”. The results also show that the coupling coordination degree of economic–social development and land ecosystem services in CCCG continues to rise steadily. Overall, the level of coupling coordination is low, and the type of coupling coordination has gradually evolved from severe and moderate imbalance to moderate coordination and mild imbalance. Therefore, the CCCG should make full use of the advantages of the “dual-core” cities to improve the level of peripheral economic linkage, increase investment in science and technology to enhance the endogenous power of economic development, establish cooperation mechanisms to narrow the urban gap, and integrate ecological resources to promote ecological industrialization to better realize the synergistic promotion of land ecological protection and high-quality economic development.
Pollution Risk Prediction for Cadmium in Soil from an Abandoned Mine Based on Random Forest Model
Authors: Cao Jie , Guo Zhaohui , Lv Yongjun , Xu Man , Huang Chiyue , Liang Huizhi
Published: March 2023

It is highly uncertain as to the potential risk of toxic metal(loid)s in abandoned mine soil. In this study, random forest was used to predict the risk of cadmium pollution in the soils of an abandoned lead/zinc mine. The results showed that the random forest model is stable and precise for the pollution risk prediction of toxic metal(loid)s. The mean of Cd, Cu, Tl, Zn, and Pb was 6.02, 1.30, 1.18, 2.03, and 2.08 times higher than the soil background values of China, respectively, and their coefficients of variation were above 30%. As a case study, cadmium in the mine soil had “slope” hazard characteristics while the ore sorting area was the major source area of cadmium. The theoretical values of the random forest model are similar to the practical values for the ore sorting area, metallogenic belt, riparian zone, smelting area, hazardous waste landfill, and mining area. The potential risk of soil Cd in the ore sorting area, metallogenic belt, and riparian zone are extremely high. The tendency of pollution risk migrates significantly both from the ore sorting area to the smelting area and the mining area, and to the hazardous waste landfill. The correlation of soil pollution risk is significant between the mining area, the smelting area, and the riparian zone. The results suggested that the random forest model can effectively evaluate and predict the potential risk of the spatial heterogeneity of toxic metal(loid)s in abandoned mine soils.