bluuebunny/crossref_metadata_2025 huggingface dataset:
Makna dan Nilai Kearifan Lokal Pada Tradisi Mallasuang Manu’ Masyarakat Mandar di Kabupaten Kotabaru
Authors: Izzah Nurul , Budhi Setia
Published: April 2024

Mallasuang Manu tradition is a ceremony of releasing a pair of chickens to be fought over by the community as a gratitude for the abundance of sea and land products which has a purpose as a ritual for local young people as a form of request to God Almighty to get a mate. The purpose of this research is to reveal the meaning in the mallasuang manu tradition. This research uses a qualitative approach. The data collection process was carried out by means of field research through participant observation, in-depth interviews and documentation. Data analysis was conducted using an interactive model, which consists of data collection, data reduction, data presentation and conclusion drawing/verification. The theory used is Herbert Blumer's symbolic interactionism. The results showed that the Mallasuang Manu' tradition is a tradition that is full of meaning. The meaning in this tradition is formed through a series of social interaction processes and meaning adjustments so that it can form a set of values, norms, rules and beliefs. The Mallasuang Manu' tradition is a local wisdom culture typical of the Mandar tribe as a result of the creation, taste and culture of the Mandar people. As local wisdom, the mallassuang manu tradition has values that contain philosophical meanings of the way of life. The meaning of morality of relationships between people manifested in mutual cooperation, the meaning of gratitude to God Almighty manifested in spiritual values, obedience, harmony, unity and unity manifested in cultural values. The conclusion is that the mallasuang manu tradition is a tradition that has been carried out for generations and is a condition of local wisdom that continues to be preserved by the people of Teluk Aru Village. It is hoped that this tradition can be further developed and managed properly as a traditional tourism asset of Kotabaru Regency, especially Teluk Aru Village.
Self-Presenting Pada Instagram Dalam Perspektif Dramaturgi di Kalangan Mahasiswa Universitas Lambung Mangkurat
Authors: Azhari Muhammad , Khairussalam
Published: April 2024

Students use Instagram as the main stage to represent themselves, build identity, and interact with followers through visual features. This study aims to explore how students present themselves on Instagram social media. The approach used is descriptive qualitative, adopting Erving Goffman's dramaturgy theory. Data were obtained through observation, interviews, and documentation. The data analysis technique follows the steps of Miles and Huberman, with the stages of data reduction, data presentation, and conclusion drawing. The results revealed that students build their image as motivators on Instagram through two approaches, namely verbal and non-verbal. Verbal motivators include the use of words, such as quotes from scripture, figures, or personal expressions. Meanwhile, non-verbal motivators are related to expressions and body language that express motivation without using words. Dramaturgical analysis identifies that the front stage is where students play a social role in front of the public, trying to maintain a positive image. While the back stage is used to hide information that may be undesirable. Students use impression management techniques in their content to shape the desired image to be accepted by others. This research provides an in-depth insight into the strategies and techniques used by university students in building an image as a motivator in cyberspace, focusing on verbal and non-verbal communication through the Instagram platform. The findings stimulate further understanding of how individuals use social media to represent themselves and build identity in the context of Goffman's dramaturgy.
Livelihood Strategy Masyarakat Pasca Banjir di Desa Bincau Muara Kecamatan Kabupaten Banjar
Authors: Werdana Aulia Rahman , Damaiyanti Varinia Pura
Published: April 2024

Bincau Muara Village, Banjar Regency, is one of the villages most severely affected by flooding in late 2020 to early 2021. This research aims to find out how the community's livelihood strategy in maintaining its sustainability after the flood in Bincau Muara Village. This research uses a qualitative approach. The informants consisted of ten people who were obtained using the snowball technique. The results showed social action (value and instrumental rationality) from the community, namely preparing at least one canoe per house for flood preparedness and taking directed steps from Village officials who must take into account the situation before the flood occurs. Then the livelihood strategy is carried out through a pentagonal asset approach, namely: 1) human capital through increased ability in economic activities that are adaptive to flooding; 2) natural capital through the utilisation of situations and conditions when flooding is occurring; 3) financial capital through strategies to fulfil economic needs after flooding that occurs for the long term; 4) social capital through optimising the function of GAPOKTAN (Gabungan Kelompok Tani) to facilitate farmer groups in terms of assistance for the continuity of their work; and, 5) physical capital through the provision of basic infrastructure and facilities in Bincau Muara Village to support the community's livelihood process. Furthermore, Gemmeinschft and Gesselschft as a support for social conditions among various social factors and livelihood strategies carried out collectively.
Drug utilization of N-Acetylcysteine in COVID-19 inpatients at Santa Elisabeth Hospital, Purwokerto
Authors: Ekowati Heny , Nadzif Faradina Qorina , Suryoputri Masita Wulandari
Published: April 2024

Background: COVID-19 is associated to an oxidant-antioxidant imbalance, which leads to inflammation and tissue damage. N-Acetylcysteine (NAC), in addition to being a mucolytic, has been shown to be an effective antioxidant in the therapy of COVID-19.
Objective: The purpose of this study is to evaluate at the NAC usage profile in COVID-19 inpatients at Santa Elisabeth Hospital in Purwokerto.
Methods: A descriptive observational design was used to perform the study. Retrospective data were obtained from medical records from July 2020 to July 2021. All patients who met the inclusion criteria were sampled using the total sampling technique.
Results: NAC was commonly administered to COVID-19 inpatients who have a mild illness of the disease. The most common symptoms were cough and fever. Patients with mild and moderate severity were given NAC orally (600 mg 3 times a day) and intravenously (5 gram/day), respectively. The duration of NAC administration was in the range of 8-14 days.
Conclusion: NAC was one of the therapies used at Santa Elisabeth Hospital Purwokerto for COVID-19 inpatients.
Optimizing effervescent granules of butterfly pea (Clitoria ternatea L) flower ethanol extract as antioxidant
Authors: Suhesti Tuti Sri , Warsinah Warsinah , Wulandari Pitra
Published: April 2024

Background: Butterfly pea (Clitoria ternatea) contains secondary metabolites, including flavonoids, saponins, terpenoids, tannins, and anthocyanins which have antioxidant activity. 
Objective: This research aims to produce the effervescent granule preparations of the butterfly pea flower ethanol extract with the optimal concentrations of citric acid and tartaric acid. 
Methods: Butterfly pea flower was extracted using 70% ethanol. Effervescent granules were made using the wet granulation method in eight formulas containing citric acid and tartaric acid. The physical properties of granules were evaluated, including extract quality, flow rate, dissolution time, and pH. 
Results: The concentration of the mixed components of citric acid 48.65 mg and tartaric acid 576.30 mg was the most optimal combination of acid sources for effervescent granules of butterfly pea flower extract with a desirability value of 1,000.                                                                                  
Conclusion: The variation in the concentration of citric acid and tartaric acid affected flow rate, dissolution time, and pH of the effervescent granule preparation.
Selection of semiempirical calculation methods for insecticide development
Authors: Iswanto Ponco , Delsy Eva Vaulina Yulistia , Setiawan Ely , Ekowati Heny
Published: April 2024

Background: Insecticides are substances used to control, repel, or eradicate troublesome organisms, particularly insect-based plant pests. The discovery of new insecticide compounds fuels the ongoing development of insecticides. The integration of computational chemistry into the development of insecticidal chemicals was beneficial.
Objective: This study aims to identify the most suitable method among 12 available semiempirical calculation methods in the Hyperchem application.
Methods: The selection process involved comparing experimental data of the infra-red spectrum of chlorpyrifos with corresponding calculation data.
Results: The largest Predicted Residual of Sum Squares (PRESS) value was observed in the INDO method of 55466.3856. Conversely, the smallest PRESS value was observed in the AM1, measuring 3242.6549. The AM1 semiempirical method yields the smallest value.
Conclusion: The results indicated that the calculation chosen was the AM1 semiempirical method.
Authors: Mutiar Sri , Yusmita Lisa , Kasim Anwar
Published: April 2024

Lead time merupakan salah satu metode yang digunakan untuk menghilangkan aktivitas-aktivitas yang tidak memberikan nilai tambah pada suatu proses produksi. Proses penyamakan kulit pada umumnya merupakan rangkaian proses yang sangat panjang dengan jumlah bahan kimia yang sangat banyak.  Proses penyamakan pada umumnya dimulai dari kulit mentah, buang bulu, buang lemah, netralisasi, pikel, penyamakan mineral, penyamakan nabati, penyamakan ulang, dan finisihing. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh waktu penyamakan terhadap karakteristik kulit tersamak yang dihasilkan. Bahan yang digunakan dalam percobaan ini menggunakan kulit kambing. Percobaaan penyamakan kulit dengan berbagai waktu penyamakan 3 jam, 6 jam, 12 jam dan 24 jam.  bahan penyamak mimosa, quebraco dan ektrak kulit kayu Acacia mangium melalui penyamakan tunggal. Analisis kualitas kulit tersamak ditentukan dari karakteristik kulit tersamak secara kimia, pengukuran sifat fisik dan organoleptis kulit tersamak. Analisis data menggunakan T test untuk melihat pengaruh perbedaan waktu. Hasil penelitian menunjukkan bahwa untuk menghasilkan kulit kambing tersamak yang memenuhi standar penggunaan waktu penyamakan ≥ 12 jam.
Relationship of Problematic Internet Use, Fear of Missing Out, Loneliness and Nomophobia among Filipino Nursing Students
Authors: Hoseña Megumi Ayagail , Mallorca Pamela Remle Irish , Muyot Yvanna Monique , Tan Iris Nicole , Calong Calong Kathyrine , Soriano Gil P
Published: April 2024

The dominance of technology use has brought growing concerns regarding its influence on human living phenomena such as problematic Internet use, fear of missing out, and nomophobia. Hence, the study aimed to determine the relationship between problematic use of the Internet, fear of missing out, loneliness, and nomophobia among nursing students. A descriptive-correlational research design was conducted with 117 nursing students selected through purposive sampling. Data were collected using an online questionnaire consisting of the Generalized Problematic Internet Use Scale 2, Fear of Missing Out Scale, Nomophobia Questionnaire, and the UCLA Loneliness Scale. Data were analyzed using frequency distribution and percentages, means, standard deviations, and Pearson’s r correlation. Results showed that problematic internet use significantly correlated with fear of missing out (r=0.223, p=0.015) and loneliness (r=0.289, p=0.002). In contrast, fear of missing out was revealed to have a significant negative relationship with nomophobia (r= -0.233, p=0.011). Despite the rise in digital activities among distance learning nursing students, loneliness and fear of missing out scores are low. However, higher nomophobia scores and strong relationships between concepts necessitate being alert to potential issues, keeping an eye on things, and adopting safety measures.
Translation, Adaptation, and Psychometric Validation of the Indonesia Version of Job Diagnostic Survey: Hospital Nurse Setting
Authors: Aungsuroch Yupin , Fisher Mary L. , Juanamasta I Gede , Wati Ni Made Nopita , Lestari R. Tri Rahyuning
Published: April 2024

A job diagnostic survey is used to measure work or job characteristics. However, there is limited study exploring the psychometric properties of the Indonesian version. This study aimed to validate the Indonesian version of the Hack and Oldham Job Diagnostic Survey.

Cronbach's alpha coefficient value showed a significant value for all evaluated dimensions. As for concurrent validity, a significant correlation was discovered between all dimensions. Construct validity for job characteristics, experienced psychological states, and affective responses to the job were significant. Cronbach's alpha coefficient value was ≥0.825 for all evaluated dimensions. As for concurrent validity, a significant correlation was found between all dimensions (r = 0.357- 0.752). Construct validity for job characteristics, experienced psychological states, and affective responses to the job were significant (χ2 = 0.00, CFI = 0.99, GFI = 0.91, RMSEA = 0.06 and SRMSR = 0.05). The Job Diagnostic Survey Indonesian version (JDS-I) has been validated, exhibits good psychometric properties, and retains the original features of the instrument.
Approximate Solution to the Schrödinger Equation of Exotic Doubly Muonic Helium-like Systems Using Hydrogenic-based Matrix Mechanics
Authors: Pingak Redi Kristian , Jacob Johanes Eliaser , Bernandus Bernandus , Johannes Albert Zicko , Setiawan Ely
Published: April 2024

The approximate solution to the Schrödinger equation of exotic doubly muonic helium-like systems has been obtained using a simple matrix method based on hydrogenic s-states. Each system considered consists of a positively charged nucleus surrounded by 2 negatively charged muons XZ+μ-μ- (2 Z 36). The present work aims to obtain approximate ground-state energies of the systems and to decompose the energies in terms of the basis states used. Here, the wave function was expressed as a linear combination of 15 eigenfunctions, each written as the product of two hydrogenic s-states. The elements of the Hamiltonian matrix were calculated and finally, the energy eigenvalue equation was numerically solved to obtain the ground-state energies of the systems with their corresponding eigenvectors. From the results, ground-state energies of all systems were in agreement with others from the literature, with percentage differences between 0.03% and 2.05%. The analysis of the probability amplitudes from the eigenvectors showed that the 1s1s state made the largest contribution to the ground state energies of the systems, approaching 90.99%, 96.98% and  98.54% for He2+μ-μ- , Li3+μ-μ- , and Be4+μ-μ- , respectively.

 

Keywords: Doubly muonic helium-like systems, ground state energy, hydrogenic basis states, matrix mechanics, Schrödinger equation
Bioactivity of Papua Red Fruit Extract (Pandanus conoideus L.) Against Superoxide dismutase, Malondialdehyde and Blood Glucose of Rat (Rattus norvegicus L.) Hyperglycemia
Authors: Mokosuli Yermia Semuel , Migau Natalina , Wurarah Masje
Published: April 2024

Red fruit (Pandanus conodus L.) is a plant native to Papua, ethnomedical used as a traditional medicine with a wide spectrum of pharmacological effects. However, research on the bioactivity of red fruit is still very poorly reported. The aim of this study was to characterize the bioactive content, antioxidant bioactivity and the effect of lowering blood glucose in hyperglycemic rats. Red fruit has extracted used the maceration method with 95% ethanol. Analysis of active compound content using Gas Chromatography Mass Spectrophotometry (GC MS). Analysis of Malondialdehyde (MDA), Superoxide dismutase (SOD) and blood glucose levels was carried out using the in vivo method using white rats. The research results showed that red fruit ethanol extract contained 173 compounds from six main groups of compounds. Red fruit extract has effective in reducing MDA levels in hyperglycemic mice. K4 and K5 treatments were the best treatments for reducing MDA. Red fruit extract affects the duration of induction of increased SOD in hyperglycemic rats. Treatments K4 and K5 were the best treatments for SOD induction. Red fruit extract affects reducing blood glucose in hyperglycemic mice. Red fruit extract has antioxidant activity and lowers blood glucose. Red fruit extract has the potential to be developed as a source of bioactive antioxidants and antidiabetics.

 

Keywords: Glucose, hyperglycemia, malondialdehyde, superoxide dismutase
The Sesquiterpenoids from the Stem Bark of Dysoxylum excelsum and Their Cytotoxic Activities against HeLa Cancer Cell Lines
Authors: Supratman Unang , Kautsari Arsi , Naini Al Arofatus , Riyadi Sandra Amalia , Mayanti Tri , Harizon Harizon , Fajriah Sofa
Published: April 2024

Sesquiterpenoids belong to a group of terpenoid compounds with interesting structures that are abundant in natural products especially in higher plants. Sesquiterpenoids have a wide variety of bioactivities with great potential cytotoxic activity. The species Dysoxylum excelsum belongs to the Meliaceae family known as higher plant, but only a few sesquiterpenoids have been reported particularly for their cytotoxic activity. Therefore, this research aims to isolate and elucidate the sesquiterpenoids structure from D. excelsum stem bark and examines their cytotoxicity against HeLa cervical cancer cells. Through various column chromatography separations, four known sesquiterpenes namely β-caryophyllene oxide (1), caryophyllenol II (2), humulene dioxide A (3), and guai-6-en-10β-ol (4) were acquired from the n-hexane extract. Compounds 1-4 were isolated for the first time from D. excelsum species. The sesquiterpenoid structures were elucidated according to Nuclear Magnetic Resonance, Infrared, and HR-TOF-MS analysis. The cytotoxicity compounds 1-4 was determined against HeLa cervical cancer cells by examination with the PrestoBlue method and compound 3 exhibited the most potent cytotoxicity with an IC50 value of 160.74 µM.

 

Keywords: cytotoxic activity, Dysoxylum excelsum, HeLa, Meliaceae, sesquiterpenoid.
Predictive model for cesarean section following labor induction at full-term pregnancy
Authors:   S.D.Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan, Sultanmuratova D.D. ,   Kazakhstan Medical University “Higher School of Public Health”, Almaty, Republic of Kazakhstan, Issenova S.Sh. ,   S.D.Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan, Kazybayeva A.S. ,   S.D.Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan, Nurbayeva T.Yu. ,   S.D.Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan, Nakhanova Zh.K. ,   Kazakhstan Medical University “Higher School of Public Health”, Almaty, Republic of Kazakhstan
Published: April 2024

Objective. To develop a predictive model for cesarean section following labor induction with low-dose oral misoprostol in women with unfavorable cervical condition at full-term gestation considering clinical and anamnestic factors. Patients and methods. A retrospective cohort study was conducted based on the analysis of labor induction histories between January 2021 and December 2022. A binomial logistic regression including important independent variables was used to develop a predictive model. Results. According to the results of multiple logistic regression, the risk of cesarean section after labor induction was significantly associated with the following variables: age (AOR: 0.91; [0.85–0.97], p = 0.004), gestational age (AOR: 0.78; [0.64–0.97], p = 0.022), Bishop score (AOR: 0.29; [0.20–0.44], p < 0.001), BMI (AOR: 1.15; [1.06–1.26], p < 0.001). Conclusion. The proposed model can be used as an objective tool to assess the risk of cesarean section in women with unfavorable cervical condition who underwent labor induction with low-dose oral misoprostol. This will allow to stratify the risks in this category of pregnant women and choose the optimal mode of delivery considering their individual characteristics. Further, it is planned to develop a convenient calculator for practical application. Key words: labor induction, misoprostol, unfavorable cervical condition, predictive model, Bishop scale
Genitourinary syndrome of menopause: possibilities of local combination therapy
Authors:   Far Eastern State Medical University, Khabarovsk, Russian Federation, Pestrikova T.Yu. , Shveeva M.A. ,   Far Eastern State Medical University, Khabarovsk, Russian Federation, Yurasova E.A. ,   Far Eastern State Medical University, Khabarovsk, Russian Federation, Veselkova E.G. ,   Far Eastern State Medical University, Khabarovsk, Russian Federation
Published: April 2024

Genitourinary syndrome of menopause (GSM) is the second most common marker of the onset of menopause, with early symptoms that can occur during perimenopause. Objective. To study the dynamics of clinical symptoms of the disease and characteristics of the vaginal microbiota in patients with GSM receiving local therapy with the medication containing Lactobacillus acidophilus and estriol. Patients and methods. The study included 62 patients with postmenopausal atrophic vaginitis. Diagnosis verification consisted of clinical examination (general and gynecological) and laboratory tests (microscopy and molecular biology testing by real-time polymerase chain reaction, determination of vaginal pH). Results. Local therapy with the medication containing Lactobacillus acidophilus and estriol in patients with postmenopausal atrophic vaginitis allowed to restore the vaginal microbiota and eliminate the symptoms of this nosological form of the disease with a statistically significant efficacy. Conclusion. The study of the vaginal microbiota showed that the type of bacterial community in women with menopause for up to 10 years or more without systemic hormone therapy was associated with the absence of Lactobacilli. Therefore, when verifying the diagnosis of atrophic vulvovaginitis, it is necessary to consider not only the presence of clinical symptoms, but also the characteristics of the vaginal microbiota, which will enable the specialists to personalize the management strategies for postmenopausal patients. Key words: atrophic vulvovaginitis, postmenopause, vaginal microbiota, vaginal tablet containing Lactobacillus acidophilus and estriol
Prenatal ultrasound diagnosis of Schaaf–Young syndrome
Authors:   Medical Center “MedGarant” LLC, Bronnitsy, Russian Federation, Grigorchuk S.E. , Turkina O.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Chekmareva N.Yu. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: April 2024

Schaaf–Yang syndrome is a rare neurodevelopmental disorder caused by pathogenic variants in the MAGEL2 gene. It is characterized by distal joint contractures, muscular hypotonia, swallowing and respiratory difficulties, and developmental delay. Prenatally, the disease manifests as abnormalities of the feet and hands, fetal hypokinesia, and polyhydramnios due to fetal swallowing difficulties. Diagnosis of Schaaf–Yang syndrome is usually made in the postnatal period. There are few publications on prenatal diagnosis of this syndrome since its ultrasonographic features are non-specific and common to many other pathological conditions. This article presents a clinical case of prenatal diagnosis and ultrasound monitoring of the fetus with feet and hand abnormalities and hypokinesia in pregnancy with severe polyhydramnios. Schaaf–Young syndrome was diagnosed postnatally by whole genome sequencing. Key words: camptodactyly, sandal gap deformity, Schaaf-Young syndrome, screening test, ultrasound diagnosis
Cervical pregnancy. Long-term outcomes of fertility-preserving hysteroscopic treatment
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Gasratova A.A. , Davydov A.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ignatko I.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Bakhtiyarov K.R. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Lebedev V.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Pashkov V.M. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Chilova R.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Shakhlamova M.N. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Rubina E.V. ,   D.D.Pletnev City Clinical Hospital, Moscow, Russian Federation
Published: April 2024

Cervical pregnancy is a rare type of ectopic pregnancy, with an incidence of 1% in relation to other types of ectopic pregnancy and one case per 18,000 of all pregnancies. Objective. To study the long-term outcomes of the treatment of patients with cervical pregnancy who underwent operative hysteroscopy with fertility preservation. Patients and methods. This prospective and retrospective open-label clinical study included 46 patients with cervical pregnancy. Patients were divided into two groups: the retrospective group (n = 29) and the prospective group (n = 17). In all cases, treatment was performed by operative hysteroscopy. Results. After hysteroscopic treatment, an intended pregnancy occurred in all women who did not use contraceptive methods. The rate of natural pregnancy was 41.3% and the rate of pregnancy following ART was 32.6% (at baseline, 36.9% of patients had ectopic pregnancy after ART procedures). A total of 39.1% of patients gave birth; no cases of ante-, intra-, or postnatal fetal death were registered during labor. The cesarean section rate was 51.8%. Conclusion. Operative hysteroscopy should be considered as the method of choice in the treatment of patients with cervical pregnancy with gestational age up to 7 weeks (in case of advanced pregnancy – up to 8 weeks), chorion localization within ½ cervical muscle thickness and absence of severe bleeding with signs of hemorrhagic shock. Key words: cervical pregnancy, operative hysteroscopy, reproductive outcomes
Investigating the influence of anatomical placental location on the complications of third stage of labor: a cross-sectional prospective study
Authors:   Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan, Memon S.G. , Ahmed S. ,   Liaquat University Hospital Hyderabad, Jamshoro, Sindh, Pakistan, Shaikh P. ,   Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan, Khaskheli L.B. ,   Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan, Bano S. ,   Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan
Published: April 2024

Objective. To investigate the influence of anatomical placental location (PL) on the duration and complications of the third stage of labor (TSL). Patients and methods. In this cross-sectional prospective study, 208 pregnant women were prospectively followed and determined at the delivery time at Tertiary Health Care Hospital Jamshoro from March 2021 to March 2022. The position of the placenta within the uterus was determined during obstetric examination by ultrasonography. The largest mass was identified by placing an ultrasonography probe at the center of the uterus and examining it through a sagittal view. Based on the placental location mass, participants were categorized into three groups: group A – anterior, group P – posterior, and group F – fundal. Results. The study found that among the 208 cases, the placenta was located in the anterior uterine wall in 54.81% (n = 114), in the posterior in 36.54% (n = 76), and in the fundal in 8.65% (n = 18). The duration of TSL was recorded in minutes in the anterior (6.31 ± 2.98), posterior (6.50 ± 3.49), and fundal (7.39 ± 3.27) placental groups, with a p-value of 0.06, indicating the non-significant difference. The placenta was separated peripherally in 25% (n = 52) of the subjects in each group and centrally in 75% (n = 176). Additionally, the delta-hematocrit value was determined in the anterior group (3.01 ± 4.28), the posterior group (3.23 ± 5.23), and the fundal group (2.81 ± 3.15); p = 0.96, indicating no significant difference. Conclusion. This research exhibited that PL did not affect the dynamics of TSL. Key words: anatomical placental location, complications, third stage of labor
Chronic sterile inflammation in the pathogenesis of benign myometrial diseases
Authors:   Patrice Lumumba Peoples’ Friendship University of Russia (RUDN), Moscow, Russian Federation, Dubinskaya E.D. , Kolesnikova S.N. ,   Medical University “Reaviz”, Moscow, Russian Federation, Aleshkina E.V. ,   Patrice Lumumba Peoples’ Friendship University of Russia (RUDN), Moscow, Russian Federation, Gasparov A.S. ,   Patrice Lumumba Peoples’ Friendship University of Russia (RUDN), Moscow, Russian Federation
Published: April 2024

This article presents an analysis of current literary sources on the role of chronic sterile inflammation in the development of proliferative diseases of the myometrium (adenomyosis, uterine fibroids). DAMPs (damage-associated molecular patterns) are considered as a significant marker of inflammation severity in these diseases. The pathogenesis of both uterine fibroids and adenomyosis is based on similar mechanisms related to chronic sterile inflammation in response to abnormal cell division. Neoangiogenesis, neoneurogenesis and fibrosis are likely to be the result of inflammation and contribute to the progression of pathological process, as well as determine its clinical manifestations (pain, heavy menstrual bleeding, infertility, miscarriage, etc.). The development of a particular pattern of pathological processes (uterine fibroids or adenomyosis) is determined by genetic and epigenetic mechanisms. Further studies of proliferative diseases of the myometrium should examine in more detail the systemic immune profile and cellular composition of the myometrium, uterine fibroids and adenomyosis to better understand the role of chronic inflammatory processes in the pathogenesis of myometrial proliferative diseases. Key words: chronic sterile inflammation, DAMPs, adenomyosis, uterine fibroids, fibrosis
Evidence-based pharmacotherapy in cardiology. National guideline
Authors: Martsevich S. Yu. , Kutishenko N. P. , Lukina Yu. V. , Yakusevich V. V. , Tolpygina S. N. , Samorodskaya I. V. , Lukyanov M. M. , Zagrebelny A. V. , Metelskaya V. A. , Poddubskaya E. A. , Drapkina O. M.
Published: April 2024

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Assessment and correction of the risk of cardiac complications during non-cardiac surgery
Authors: Sumin A. N.
Published: April 2024

About 300 million non-cardiac operations are performed annually worldwide. In developed countries, an increasing number of such operations are performed in older patients with comorbid cardiac pathology. The leading cause of perioperative mortality is cardiovascular complications. The national and international guidelines published in the last year on cardiovascular assessment and correction of the risk of cardiac complications during non-cardiac operations contain several contradictory provisions. First of all, this refers to the methods of preoperative risk assessment: which is better — to base on scales, functional status assessment or biomarkers (BNP/ NT-pro-BNP) determination? Questions remain about the most appropriate algorithm for preoperative evaluation of patients with suspected cardiac pathology (the need for preoperative non-invasive tests or limited to biomarkers evaluation), some of these algorithms have been validated in recent studies. Several publications address the problem of drug therapy in non-cardiac surgery, both previously studied drugs (statins, beta-blockers) and new ones (colchicine, nicorandil). Perioperative myocardial injury syndrome and its possible drug prevention continue to be studied. This review considers recent publications on this topic, which have not yet been reflected in the guidelines and may influence their correction in the future. The article also discusses the problems of implementing existing guidelines in clinical practice. The publications of the last year presented in the review help researchers and practitioners to form their views on existing controversial issues. Ultimately, this will promote the use of an individualized approach in the management of this category of patients.
Effectiveness of different treatment regimens of enhanced external counterpulsation in patients with stable coronary artery disease complicated by heart failure
Authors: Lishuta A. S. , Slepova O. A. , Nikolaeva N. A. , Khabarova N. V. , Privalova E. V. , Belenkov Yu. N.
Published: April 2024

Aim. To study the effect of various therapy regimens with enhanced external counterpulsation (EECP) on exercise tolerance, quality of life, indices of structural and functional state of cardiovascular system in patients with stable coronary artery disease (CAD) complicated by chronic heart failure (CHF).

Material and methods. The study included patients with stable CAD complicated by CHF with reduced and intermediate left ventricular ejection fraction (LVEF) from the randomized EXCEL trial (NCT05913778; n=120) and additionally patients with similar inclusion and exclusion criteria (n=90) who were randomized into groups with different EECP treatment regimens for 12 months: Group 1 (n=40): course of 35 hour-long procedures; Group 2 (n=40): course of 35 hourlong procedures every 6 months; Group 3 (n=30): course of 20 hour-long procedures then constantly 1 hour per week; Group 4 (n=30): constantly 2 hours per week; Group 5 (n=30): course of 20 hour-long procedures then constantly 2 hours per week; Group 0 (placebo ; n=40): course of 35 hour-long procedures with compression pressure 80 mm Hg. All patients at baseline and after 12 months were assessed for clinical status, quality of life (MLHFQ, SF-36), NT-proBNP levels, LVEF, as well as exercise tolerance (6-minute walk test; 6MWT) initially, after 3, 6, 9 and 12 months. Correlation analysis and risk assessment of adverse events (combined endpoint — combination of cases of adverse cardiovascular events, deaths, hospitalizations for CHF, new-onset of atrial fibrillation, diabetes, decreased renal function) was performed.

Results. Treatment effectiveness had positive correlation with EECP duration (r(S)=0,670; p<0,001) and treatment regimen (r(S)=0,620; p<0,001). The maximum effect (changes in NT-proBNP levels, LVEF, clinical status, quality of life) was noted in the combined and constant regimen groups (5, 4, 2). The increase of 6WMTdistance was 6,6% in group 0, 24,9% in group 1, 44,5% in group 2, 31,8% in group 3, 49,1% in group 4, 58,6% in group 5. The proportion of patients with an increase in 6WMT-distance >20% after 12 months was 7,7%, 72,5%, 97,5%, 76,7%, 90%, 100%, respectively. Cumulative event-free survival was highest in groups 5, 4, and 2 (0,97, 0,93, and 0,86, respectively), and the risk of developing combined endpoint in these groups was minimal (0,035, 0,075, and 0,150, respectively).

Conclusion. The effect of EECP treatment in patients with coronary artery disease complicated by CHF depended on the EECP hours and regimen. Alternative EECP regimens (with more treatments spread evenly over the year) in addition to optimal medical therapy may improve the management of these patients.
THE ROLE OF BUSINESS MODEL CANVAS (BMC) IN DIGITAL ENTREPRENEURSHIP ON STUDENTS' INTEREST IN INDONESIA
Authors: Rizan Mohamad , Sumastuti Efriyani , Prabowo Heri , Kresnamurti Agung , Chalida Hanoum Farah
Published: April 2024

Unemployment of the productive age population is a big challenge for Indonesia entering the era of free markets and global competition. Creating young entrepreneurs is a solution that can be done to strengthen economic growth. Indonesia produces 700 thousand graduates annually, but many Indonesian students show limited interest in entrepreneurship. A lack of understanding of entrepreneurship makes students more likely to find jobs than create jobs. This research aims to provide an understanding to students regarding the importance of entrepreneurship and stimulate the growth of an entrepreneurial mindset among them. This is achieved by introducing and understanding in depth the Business Model Canvas (BMC), so that students can start and run businesses, so as to be able to transform them into job creators. The research method used is a causal / explanatory survey, using primary data collected through participatory observation, interviews, and questionnaires distributed to selected public and private universities in Indonesia using convenience / accidental sampling techniques. The questionnaire was distributed to a total of 200 respondents, in accordance with the minimum sample size requirements for the Structural Equation Modeling (SEM) analysis technique, using LISREL software version 8.8. The findings of this study show that customer segments, value proportions, channels, customer relationships, revenue streams, key resources, key activities, key partnerships, and cost structures are able to increase entrepreneurial interest. Business Model Canvas (BMC) effectively increases students' understanding of entrepreneurship. BMC's simplicity in mapping and presenting business models makes it an effective tool to deepen business understanding. However, BMC is not an instant tool that can necessarily improve students' entrepreneurial mindset. Understanding BMC is the same as other sciences that cannot be taught in a short time and requires a process to learn it. The timeframe available in the study was very short and did not meet the requirements to cultivate a mindset that was truly expected to prepare students to engage fully as entrepreneurs.
Measuring Critical Thinking Skills through Performance Assessment: The Profile of EFL Students’ Critical Thinking Skills
Authors: Jumariati Jumariati , Asrimawati Inayati Fitriyah , Mulya Jauza Naja , Taka Deo Deo Laki
Published: April 2024

This study tries to find the profiles of EFL students' critical thinking skills in writing problem-solution expository essays within wetland themes. It employs a quantitative descriptive design by utilizing a validated writing test. The subjects of the study were 40 students of the English Language Education Study Program of the University of Lambung Mangkurat, Indonesia, who were enrolled in the Academic Writing courses. The essay produced by each student was measured based on the depth of cause-and-effect analysis, the logic of the argument given, the viability of the solution, and the validity of evidence used to support the argument. The findings reveal that the subjects’ critical thinking skill is categorized as medium since the mean score on the test of critical thinking is 11.38. Particularly, they have a high level of critical thinking in the aspects of analyzing the issue (3.03) and providing viable solutions (3.18). It indicates that they are able to distinguish the cause of a problem and the consequences as well and consider the causes and consequences when they propose a solution. However, their skill in providing argument is medium (2.85) whereas their skill in providing the evidence is low (2.33). These findings suggest that the subjects need to be trained in providing arguments and sufficient evidence through leading questions, discussion, and reading relevant sources. It implies that the study program needs to develop a teaching model that facilitates the students to practice their critical thinking skills.
Equinor Leads Project To Turn Ubiquitous Drill Cuttings Into Precious PVT Samples
Authors: Jacobs Trent
Published: April 2024

They were told it wouldn’t work.

But in a new study, experts at Equinor and Applied Petroleum Technology (APT) suggest they are on the brink of using contaminated drill cuttings to predict critical reservoir fluid properties.

The two Norwegian firms believe their project will soon make it possible to treat cuttings, collected from each well, as if they were pressure/volume/temperature (PVT) samples, which are collected from a significantly smaller share of wells due to the risks and high cost of doing so.

Since its inception in 1972, Equinor has drilled over 5,000 offshore wells, from which just over 2,000 PVT samples have been gathered.

Given that only two or three good samples are taken from most wells—almost always exploration wells—a significant data gap exists for the remainder, most of which are the subsequent development wells. And each year, Equinor drills around 20 to 25 new wells, mostly near existing platforms.

If oil and gas firms could obtain PVT-like results from cuttings alone, they would presumably gain more precise guidance on where to place new wells along with insights on facility/topside design, reservoir management, and eventually on the plugging and abandonment phase.

The big obstacle Equinor and APT are trying to surmount centers on how rock cuttings are soaked in oil-based muds (OBMs) as they circulate up the wellbore before being collected from a shale shaker. The oil ends up masking the reservoir’s hydrocarbons, rendering traditional geochemistry methods ineffective.

What Equinor has shown in its study is that problem can be circumvented to obtain reliable estimates of API gravity and viscosity, two defining aspects of reservoir fluid quality and flow potential. Several more outputs are in the works.

Tao Yang, an industry-recognized reservoir expert and chief professional at Equinor, said when he spoke with geochemists in the company about the project nearly 2 years ago, they were decidedly dubious.

“They gave us a warning at the beginning and said that this was a very difficult area, that the cuttings were too dirty, and that we probably wouldn’t get anything out of them,” he said.

But what few in the upstream industry knew at the time is that there existed a technology that can overcome the contamination issue—and it has been around for decades. Invented in the 1960s, gel permeation chromatography (GPC) coupled with ultraviolet (UV) absorbance detection, or simply GPC-UV, is used primarily by the chemicals sector for polymer analysis.

The GPC aspect separates molecules based on their size as they flow through a gel-filled column. The smaller molecules take the longest to pass through while the larger molecules move more rapidly—the opposite of how most geochemistry assays work.

As the molecules move down the column, they are exposed to UV light. Depending on their chemical structure, each molecule will absorb light at varying intensities which in turn can be measured and used to detect the presence of various compounds, including those indicative of oil.
Efficient Plug Milling and Cleaning Solution with Customized Slim Hole Bottomhole Assembly for Recompleted Wells – A Case History
Authors: Unnikrishnan Vikram , Navin Guruswami
Published: April 2024

In North America, refracturing existing fracked shale wells, is carried out by installing smaller liners with the already proven success of using frac plugs for zonal isolation. Post stimulation, intervention operation is carried out to remove the plugs via milling on coiled tubing. Due to restricted Internal Diameter (ID) of the smaller liner, it was critical to deploy slim hole downhole tools which is fishable but still allows higher flow rate capacities with lowest pressure drops to maximize clean out efficiency.

Smaller casing/liner, smaller Coiled Tubing (CT) Outer Diameter (OD), higher wellhead pressures, higher circulating pressures, smaller OD Bottomhole Assembly/s (BHA), tougher frac plugs etc. make wellbore cleanout more challenging than a newly completed well. Under normal circumstances, a 2" OD CT in a smaller casing/liner ID, should be able to provide the desired Weight on Bit (WOB) for millout, however in this case based on modelling, it was determined that an extended reach tool would be required to achieve the objective.

This paper will discuss the steps incorporated to configure slim hole BHA at higher flow rates, which includes the workover motor and the extended reach tool, to successfully remove frac plugs inside refrac liner. Several dynamometer flow tests on the motors were conducted at higher than published design flow rate and post disassembly inspections were made to ensure the motor maintained full integrity and reliability at higher flow rates. The extended reach tool vendor modified the tool for higher flow rate capacity to provide maximum traction force.

This tailor-made approach eliminated the need for a diverter sub, historically used in these applications to achieve higher flow rates of ~2.6 Barrels Per Minute (BPM). Excluding the diverter sub, assured no compromise to the motor's power delivery, or the traction force of the extended reach tool. By maintaining 2.6 BPM, it increased annular velocities by 30% resulting in improved solid transport for efficient clean out in three wells each with ~ 16,500 ft Measured Depth (MD). This approach has resulted in an overall time saving of 65 hours to the operator compared to previous jobs allowing to save up to $130k USD in three well pad with average wellhead pressures of 4,000 psi inside 3-1/4" 7.9 lb/ft liner.
Development and Internal Validation of a Novel Pre-Transplant Biomarker Panel to Predict Post-Transplant Mortality in Liver Transplant Recipients
Authors: Panayotova Guergana G. , Simonishvili Sopio , Nguyen Duc T. , Graviss Edward A. , Aware Nikita , Manner Carl J. , Minze Laurie J. , Ayorinde Tumininu , Qin Yong , Jin Lianhua , Lemenze Alexander , Mysore Krupa R. , Moore Linda , Paterno Flavio , Saharia Ashish , Mobley Constance M. , Amin Arpit , Hobeika Mark J. , Pyrsopoulos Nikolaos , Li Xian C. , Guarrera James V. , Ghobrial R. Mark , Lunsford Keri E.
Published: April 2024

Background and Aims
Current scoring systems accurately predict risk of pre-liver transplant (LT) mortality but fall short in estimation of post-LT survival. This study seeks to identify biomarkers of pre-LT immune dysfunction that predict mortality following LT.
Methods
From 10/1/13 − 3/23/21, 279 cirrhotic patients underwent assessment of plasma biomarker (Luminex) and clinical variables immediately prior to LT (T0).
Results
Cox-proportional hazards modeling identified HCV IgG, Fractalkine, and MMP3 as multivariate predictors of 1-year mortality, with covariate selection by clinical importance and LASSO methodology. These were utilized to comprise the novel Liver Immune Frailty Index (LIFI), which stratifies recipients into -low, -moderate, and –high risk tertiles. One-year mortality was 1.4%, 12.7%, and 58.3% for LIFI-low, -moderate, and -high, respectively. Internal validation through bootstrap resampling with 2000 replicates demonstrates LIFI predicts early post-LT mortality with C-statistic = 0.84 and Brier score of 0.04. LIFI-high is not dependent upon HCV status. The relative contribution of the continuous variables in the LIFI calculation exceeded the discrete HCV IgG binary variable contribution. Stratification into either LIFI-high or moderate requires cumulative contribution of elevated MMP3 and Fractalkine levels. Excluding HCV IgG+ as a covariate similarly stratifies patients at high-, moderate-, and low-risk of early futility after LT based only on MMP3 and Fractalkine levels (C-statistic 0.83).
Conclusions
LIFI may identify patients at risk for persistent severe immune dysfunction and early mortality following LT.