bluuebunny/crossref_metadata_2025 huggingface dataset:
Chlorinated Narrow Bandgap Polymer Suppresses Non‐Radiative Recombination Energy Loss Enabling Perylene Diimides‐Based Organic Solar Cells Exceeding 10% Efficiency
Authors: Gao Xiang , Tong Xinzhu , Xu Meichen , Zhang Linhua , Wang Yinuo , Liu Zhihao , Yang Lvpeng , Gao Jianhong , Shao Ming , Liu Zhitian
Published: April 2023

The scarcity of narrow bandgap donor polymers matched with perylene diimides (PDI)‐based nonfullerene acceptors (NFAs) hinders improvement of the power conversion efficiency (PCE) value of organic solar cells (OSCs). Here, it is reported that a narrow bandgap donor polymer PDX, the chlorinated derivative of the famous polymer donor PTB7‐Th, blended with PDI‐based NFA boosts the PCE value exceeding 10%. The electroluminescent quantum efficiency of PDX‐based OSCs is two orders of magnitude higher than that of PTB7‐Th‐based OSCs;therefore, the nonradiative energy loss is 0.103 eV lower. This is the highest PCE value for OSCs with the lowest energy loss using the blend of PTB7‐Th derivatives and PDI‐based NFAs as the active layer. Besides, PDX‐based devices showed larger phase separation, faster charge mobilities, higher exciton dissociation probability, suppressed charge recombination, elevated charge transfer state, and decreased energetic disorder compared with the PTB7‐Th‐based OSCs. All these factors contribute to the simultaneously improved short circuit current density, open circuit voltage, and fill factor, thus significantly improving PCE. These results prove that chlorinated conjugated side thienyl groups can efficiently suppress the non‐radiative energy loss and highlight the importance of fine‐modifying or developing novel narrow bandgap polymers to further elevate the PCE value of PDI‐based OSCs.
Regional Planning and Optimization of Renewable Energy Sources for Improved Rural Electrification
Authors: Shahrom Sarah Farhana , Aviso Kathleen B. , Tan Raymond R. , Saleem Nor Nazeelah , Ng Denny K. S. , Andiappan Viknesh
Published: April 2023

Over 13% of the global population (most of which are rural communities) still lack access to electricity. A typical resolution to this would be to generate more electricity from existing power generation infrastructure. However, the urgency to meet net-zero global greenhouse gas emissions means that this resolution may not be the way forward. Instead, policymakers must consider decarbonization strategies such as renewable energy systems to generate more electricity in rural communities. As policymakers aim to encourage renewable energy generation, existing power plant operators may not share the same perspective. Operators typically wish to ensure profit margins in their operations as decarbonization efforts may be costly and reduce the profit. A balance must be struck between both parties so that the energy sector can continue to meet rising energy demands and decarbonization needs. This is a classic leader–follower situation where it involves the interplay between policymaker (as energy sector regulator) and industry (as energy sector investor). This work presents a bi-level optimization model to address the leader–follower interactions between policymakers and industry operators. The proposed model considers factors such as total investment, co-firing opportunities, incentives, disincentives, carbon emissions, scale, cost, and efficiency to meet electricity demands. To demonstrate the model, two Malaysian case studies were evaluated and presented. The first optimized networks is developed based on different energy demands. Results showed that when cost was minimized, the production capacity of the existing power plants was increased and renewable energy systems were not be selected. The second case study used bi-level optimization to determine an optimal trade-off $ 1.4 million in incentives per year, which serves as a monetary sum needed by policymakers to encourage industry operators to decarbonize their operations. Results from the second case were then compared to the ones in the first.
Deciphering the roles of ammonium doping for lead-free (NH4)xCs3−xCu2I5 perovskites to regulate the photoelectronic properties
Authors: Xu Zeyao , Jiang Linqin , Xiong Hao , Wen Jiansen , Li Ping , Lin Lingyan , Wu Bo , Yang Aijun , Qiu Yu
Published: April 2023

Stable NH4+-doped (NH4)xCs3−xCu2I5 perovskites were successfully synthesized via the eco-friendly ball milling method and exhibit high deep-blue PLQYs. Their pc-LEDs show improved and tunable emission spectra.
Knotted Stent—Emphasizing the Need of Radiology Assistance in Urology
Authors: Dhangar Sanjay P.
Published: April 2023

Ureteral double-J stents have become a part and parcel in contemporary urologic practice. As the use of stents is increasing, the complications are also increasing. Knot formation in the double-J stent is rare phenomenon. Twenty-seven cases have been reported till now. This case would be the 28th case to be reported, in a young male with solitary left kidney and who was on regular periodic stent substitution.
Nicotinamide-N-methyltransferase regulates lipid metabolism via SAM and 1-methylnicotinamide in the AML12 hepatocyte cell line
Authors: Yoda Mayuko , Mizuno Rin , Izumi Yoshihiro , Takahashi Masatomo , Bamba Takeshi , Kawaoka Shinpei
Published: April 2023

Nicotinamide-N-methyltransferase (NNMT) is an enzyme that consumes S-adenosyl-methionine (SAM) and nicotinamide (NAM) to produce S-adenosyl-homocysteine (SAH) and 1-methylnicotinamide (MNAM). How much NNMT contributes to the quantity regulation of these four metabolites depends on whether NNMT is a major consumer or producer of these metabolites, which varies among various cellular contexts. Yet, whether NNMT critically regulates these metabolites in the AML12 hepatocyte cell line has been unexplored. To address this, we knockdown Nnmt in AML12 cells and investigate the effects of Nnmt RNAi on metabolism and gene expression. We find that Nnmt RNAi accumulates SAM and SAH, whereas it reduces MNAM with NAM being unaltered. These results indicate that NNMT is a significant consumer of SAM and critical for MNAM production in this cell line. Moreover, transcriptome analyses reveal that altered SAM and MNAM homeostasis is accompanied by various detrimental molecular phenotypes, as exemplified by the down-regulations of lipogenic genes, such as Srebf1. Consistent with this, oil-red O-staining experiments demonstrate the decrease of total neutral lipids upon Nnmt RNAi. Treating Nnmt RNAi AML12 cells with cycloleucine, an inhibitor of SAM biogenesis suppresses SAM accumulation and rescues the decrease of neutral lipids. MNAM also shows activity to elevate neutral lipids. These results suggest that NNMT contributes to lipid metabolism by maintaining proper SAM and MNAM homeostasis. This study provides an additional example where NNMT plays a critical role in regulating SAM and MNAM metabolism.
Ambivalent role of FasL in murine acute graft-versus-host-disease
Authors: Bernard-Bloch Robin , Lebrault Eden , Li Xiaofan , Sutra Del Galy Aurélien , Garcia Arlette , Doliger Christelle , Parietti Véronique , Legembre Patrick , Socié Gérard , Karray Saoussen
Published: April 2023

Fas ligand is increased in several immune-mediated diseases, including acute graft-versus-host disease, a donor cell–mediated disorder post–hematopoietic stem cell transplantation. In this disease, Fas ligand is involved in T-cell–mediated damage to host tissues. However, the role of its expression on donor non–T cells has, so far, never been addressed. Using a well-established CD4- and CD8-mediated graft-versus-host disease murine model, we found that precocious gut damage and mice mortality are increased with a graft of donor T- and B-depleted bone marrow cells devoid of Fas ligand as compared with their wild-type counterparts. Interestingly, serum levels of both soluble Fas ligand and IL-18 are drastically reduced in the recipients of Fas ligand–deficient grafts, indicating that soluble Fas ligand stems from donor bone marrow–derived cells. In addition, the correlation between the concentrations of these 2 cytokines suggests that IL-18 production arises through a soluble Fas ligand–driven mechanism. These data highlight the importance of Fas ligand–dependent production in IL-18 production and in mitigating acute graft-versus-host disease. Overall, our data reveal the functional duality of Fas ligand according to its source.
Real-World Effectiveness of Gelatin-Thrombin Matrix Sealant on Blood Loss in Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion
Authors: Mimura Tetsuhiko , Ikegami Shota , Uehara Masashi , Oba Hiroki , Hatakenaka Terue , Kamanaka Takayuki , Miyaoka Yoshinari , Kurogochi Daisuke , Fukuzawa Takuma , Koseki Michihiko , Takahashi Jun
Published: April 2023

Study Design.

Retrospective cohort study with interrupted time series analysis.

Objective.

To examine the clinical effectiveness of gelatin-thrombin matrix sealant (GTMS) on blood loss reduction after adolescent idiopathic scoliosis (AIS) surgery.

Summary of Background Data.

The real-world effectiveness of GTMS on blood loss reduction in AIS surgery has not been determined.

Patients and Methods.

The medical records of patients receiving AIS surgery were retrospectively collected during a period before GTMS approval at our institution (January 22, 2010–January 21, 2015) as well as during a postintroduction period (January 22, 2015–January 22, 2020). The primary outcomes were intraoperative blood loss, drain output over 24 hours, and total blood loss (intraoperative blood loss + drain output over 24 h). Interrupted time series analysis using a segmented linear regression model was used to estimate the effect of GTMS on blood loss reduction.

Results.

A total of 179 AIS patients [mean age (range): 15.4 (11–30) yr; 159 females and 20 males; 63 preintroduction patients and 116 postintroduction patients] were included. After its introduction, GTMS was used in 40% of cases. Interrupted time series analysis revealed changes of −340 mL (95% CI: −649 to −31, P = 0.03) for intraoperative blood loss, −35 mL (95% CI: −124 to 55, P = 0.44) for drain output over 24 hours, and −375 mL (95% CI: −698 to −51, P = 0.02) for total blood loss.

Conclusions.

The availability of GTMS was significantly associated with reduced intraoperative and total blood loss in AIS surgery. GTMS use as needed is recommended to control intraoperative bleeding in the setting of AIS surgery.

Level of Evidence.

3.
DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection
Authors: Wegman Adam D. , Waldran Mitchell J. , Bahr Lauren E. , Lu Joseph Q. , Baxter Kristen E. , Thomas Stephen J , Waickman Adam T.
Published: April 2023

Dengue represents a growing public health burden worldwide, accounting for approximately 100 million symptomatic cases and tens of thousands of fatalities yearly. Prior infection with one serotype of dengue virus (DENV) is the greatest known risk factor for severe disease upon secondary infection with a heterologous serotype, a risk which increases as serotypes co-circulate in endemic regions. This disease risk is thought to be mediated by IgG-isotype antibodies raised during a primary infection, which poorly neutralize heterologous DENV serotypes and instead opsonize virions for uptake by FcγR-bearing cells. This antibody-dependent enhancement (ADE) of infection leads to a larger proportion of susceptible cells infected, higher viremia and greater immunopathology. We have previously characterized the induction of a serum IgA response, along with the typical IgM and IgG responses, during dengue infection, and have shown that DENV-reactive IgA can neutralize DENV and competitively antagonize IgG-mediated ADE. Here, we evaluate the potential for IgA itself to cause ADE. We show that IgG, but not IgA, mediated ADE of infection in cells expressing both FcαR and FcγRs. IgG-mediated ADE stimulated significantly higher pro-inflammatory cytokine production by primary human macrophages, while IgA did not affect, or slightly suppressed, this production. Mechanistically, we show that DENV/IgG immune complexes bind susceptible cells significantly more efficiently than DENV/IgA complexes or virus alone. Finally, we show that over the course of primary dengue infection, the expression of FcγRI (CD64) increases during the period of acute viremia, while FcγRIIa (CD32) and FcαR (CD89) expression decreases, thereby further limiting the ability of IgA to facilitate ADE in the presence of DENV. Overall, these data illustrate the distinct protective role of IgA during ADE of dengue infection and highlight the potential therapeutic and prognostic value of DENV-specific IgA.
IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1β secretion
Authors: Dinarello Alberto , May Makenna , Amo-Aparicio Jesus , Azam Tania , Gaballa Joseph M , Marchetti Carlo , Tesoriere Annachiara , Ghirardo Rachele , Redzic Jasmina S , Webber William , Atif Shaikh M , Li Suzhao , Eisenmesser Elan Z , de Graaf Dennis M , Dinarello Charles A
Published: April 2023

The IL-1 Family member IL-38 has been characterized primarily as an anti-inflammatory cytokine in human and mouse models of systemic diseases. Here, we examined the role of IL-38 in the murine small intestine (SI). Immunostaining of SI revealed that IL-38 expression partially confines to intestinal stem cells. Cultures of intestinal organoids reveal IL-38 functions as a growth factor by increasing organoid size via inducing WNT3a. In contrast, organoids from IL-38 deficient mice develop more slowly. This reduction in size is likely due to downregulation of intestinal stemness markers (i.e.,Fzd5,Ephb2,Olfm4) expression compared with wild type organoids. IL-38 binding to IL-1R6 is postulated to recruit the co-receptor IL-1R9. Therefore, to analyze the molecular mechanisms of IL-38 signaling, we also examined organoids from IL-1R9 deficient mice. Unexpectedly, these organoids, although significantly smaller than wild type, respond to IL-38, suggesting that IL-1R9 is not involved in IL-38 signaling in the stem cell crypt. Nevertheless, silencing of IL-1R6 disabled the organoid response to the growth property of IL-38, thus suggesting IL-1R6 as the main receptor used by IL-38 in the crypt compartment. In organoids from wild type mice, IL-38 stimulation induced low concentrations of IL-1β which contribute to organoid growth. However, high concentrations of IL-1β have detrimental effects on the cultures that were prevented by treatment with recombinant IL-38. Overall, our data demonstrate an important regulatory function of IL-38 as a growth factor, and as an anti-inflammatory molecule in the SI, maintaining homeostasis.

Significance

The IL-1 family member IL-38 has been characterized primarily as an anti-inflammatory cytokine for systemic diseases. Here we describe a fundamental role of IL-38 in driving intestinal stem cell differentiation through the upregulation of WNT3a and IL-1β. Our findings reveal a dual role of IL-38 in regulating intestinal functions; (a) in resting conditions IL-38 maintains intestinal homeostasis, driving WNT3a production and organoid budding, whereas (b) in highly inflamed conditions, IL-38 contributes to proper recovery, by exerting anti-inflammatory activities. Thus, we demonstrate a pivotal role of IL-38 in driving tissue turnover and maintenance of homeostasis in intestinal health.
Carbon toolmaking: responding to multiple interacting logics in carbon management
Authors: Bui Binh , Wang Zichao (Alex) , Tekathen Matthäus
Published: April 2023

Purpose

This study examines how carbon tools, including carbon accounting and management tools, can be created, used, modified and linked with other traditional management controls to materialise and effectuate organisations’ response strategies to multiple interacting logics in carbon management and the role of sustainability managers in these processes.

Design/methodology/approach

This study utilises the construct of accounting toolmaking, which refers to practices of adopting, adjusting and reconfiguring accounting tools to unfold how carbon tools are used as means to materialise responses to multiple interacting carbon management logics. It embraces a field study approach, whereby 38 sustainability managers and staff from 30 organisations in New Zealand were interviewed.

Findings

This study finds that carbon toolmaking is an important means to materialise and effectuate organisations’ response strategies to multiple interacting carbon management logics. Four response strategies are identified: separation, selective coupling, combination and hybridisation. Adopting activity involves considering the additionality, detailing, localising and cascading of carbon measures and targets and their linkage to the broader carbon management programme. In adjusting carbon tools, organisations adapt the frequency and orientation of carbon reporting, intensity of carbon monitoring and breadth of carbon information sharing. Through focusing on either procedural sequencing, assimilating, equating or integrating, toolmaking reconfigures the relationship between carbon tools and traditional management control systems. Together, these three toolmaking activities can be configured differently to construct carbon tools that are fit for purpose for each response strategy. These activities also enact certain roles on sustainability managers in the process of representing, communicating and/or transferring carbon information knowledge, which also facilitate different response strategies.

Practical implications

The study demonstrates the various carbon toolmaking practices that allow organisations to handle the multiple interacting logics in carbon management. The findings provide suggestions for organisations on how to adopt, adjust and reconfigure carbon tools to better embed the ecological logic in organisations’ strategies and operations.

Originality/value

The authors identify how carbon toolmaking materialises and effectuates organisations’ responses to multiple interacting logics in carbon management.
Social media, echo chambers and contingency: a system theoretical approach about communication in the digital space
Authors: Rodrigues da Cunha Palmieri Emerson
Published: April 2023

Purpose

There is a growing worry about people possibly isolating themselves in online bubbles and avoiding contact with ideas that differ from their beliefs, creating a scenario of ideological polarization. To investigate into this matter, this work aims for a reflection about the contingency of communication in social media. Does social media make the experience of communication in the digital space more contingent (providing it with more possibilities, with people accessing different contents and ideas) or less contingent (reducing the available possibilities, making people isolate themselves)?

Design/methodology/approach

This is a theoretical work, constructed through bibliographical reviews. To reflect about the question that are posed, the author selected Niklas Luhmann's social systems theory to approach the concept of contingency. In addition to that, the author presented the main arguments of the debates about echo chambers and online bubbles. In the end, the author combined the two reviews together using elements of the Luhmannian theory and drew some conclusions about the initial question.

Findings

The study concluded that social media have an ambivalent potential regarding contingency in the digital space: it can both expand or reduce the available possibilities of communication, depending on criteria like topic, potential of diffusion and focus of attention. There is no one-side effect.

Research limitations/implications

The approach at echo chambers does not reflect “the” form of contingency in social media, but “a” form. Therefore, the study cannot provide any general conclusions about the relation between contingency and social media. The digital space is a large one, and more studies are required to achieve more substantial propositions.

Originality/value

The research has an originality value both for systems theory and social media studies. First, because, as far as the author knows, no other system-theoretical argument has taken the connection between contingency and social media as a primary analysis object. Second, because of a theoretical interpretation effort, the studies of echo chambers indicate mixed results about the phenomenon of online isolation, but no attempt was made to make sense of these mixed results from a specific sociological theory. The author did that by using Luhmann's theoretical framework, which proved to be a good tool for explaining and unifying these different results on a more abstract level.
Orbit equivalence rigidity of irreducible actions of right-angled Artin groups
Authors: Horbez Camille , Huang Jingyin , Ioana Adrian
Published: April 2023

Let $G_\Gamma \curvearrowright X$ and $G_\Lambda \curvearrowright Y$ be two free measure-preserving actions of one-ended right-angled Artin groups with trivial center on standard probability spaces. Assume they are irreducible, i.e. every element from a standard generating set acts ergodically. We prove that if the two actions are stably orbit equivalent (or merely stably $W^*$-equivalent), then they are automatically conjugate through a group isomorphism between $G_\Gamma$ and $G_\Lambda$. Through work of Monod and Shalom, we derive a superrigidity statement: if the action $G_\Gamma \curvearrowright X$ is stably orbit equivalent (or merely stably $W^*$-equivalent) to a free, measure-preserving, mildly mixing action of a countable group, then the two actions are virtually conjugate. We also use the works of Popa and Ioana, Popa and Vaes to establish the $W^*$-superrigidity of Bernoulli actions of all infinite conjugacy classes groups having a finite generating set made of infinite-order elements where two consecutive elements commute, and one has a nonamenable centralizer: these include one-ended nonabelian right-angled Artin groups, but also many other Artin groups and most mapping class groups of finite-type surfaces.
Figure S2 from Modeling High-Grade Serous Ovarian Carcinoma Using a Combination of In Vivo Fallopian Tube Electroporation and CRISPR-Cas9–Mediated Genome Editing
Authors: Teng Katie , Ford Matthew J. , Harwalkar Keerthana , Li YuQi , Pacis Alain S. , Farnell David , Yamanaka Nobuko , Wang Yu-Chang , Badescu Dunarel , Ton Nu Tuyet Nhung , Ragoussis Jiannis , Huntsman David G. , Arseneau Jocelyne , Yamanaka Yojiro
Published: April 2023

Summary of tumour genotyping
Supplementary Data from AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis
Authors: Sun Yu , Li Xin , Yin Chengqian , Zhang Judy , Liang Ershang , Wu Xianfang , Ni Ying , Arbesman Joshua , Goding Colin R. , Chen Shuyang
Published: April 2023

Figure S1-S5
Supplementary Dataset 4 from SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
Authors: Chambers Courtney , Cermakova Katerina , Chan Yuen San , Kurtz Kristen , Wohlan Katharina , Lewis Andrew Henry , Wang Christiana , Pham Anh , Dejmek Milan , Sala Michal , Loeza Cabrera Mario , Aguilar Rogelio , Nencka Radim , Lacorazza H. Daniel , Rau Rachel E. , Hodges H. Courtney
Published: April 2023

Complete blood counts
Supplementary Dataset 3 from SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
Authors: Chambers Courtney , Cermakova Katerina , Chan Yuen San , Kurtz Kristen , Wohlan Katharina , Lewis Andrew Henry , Wang Christiana , Pham Anh , Dejmek Milan , Sala Michal , Loeza Cabrera Mario , Aguilar Rogelio , Nencka Radim , Lacorazza H. Daniel , Rau Rachel E. , Hodges H. Courtney
Published: April 2023

Motif profiling
Table ST4 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

Table ST4: Table of the 15 most informative proteins upregulated in MEK inhibitor-sensitive cell culture (ranked by log2 fold-change).
Table ST1 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

Table ST1: Summary of growth inhibitory IC50 values (including the corresponding 95% confident intervals (C.I.95%) conducted for neocuproine or MEKi (binimetinib) and primary human cell lines. The table includes the confirmed oncogenic mutation as well as the ratio of neocuproine normalized to the MEKi response.
Suppl. Figure S8 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

S8: Lipidomics
Suppl. Figure S3 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

S3: Correlation between MEKi responsiveness and sensitivity to nNeocuproine
Suppl. Figure S13 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

S13: Immunohistochemical analysis of CyTof biomarker panel.
Suppl Figure S4 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

S4: Neocuproine is a copper-dependent ROS inducer
Suppl Figure S11 from ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
Authors: Eichhoff Ossia M. , Stoffel Corinne I. , Käsler Jan , Briker Luzia , Turko Patrick , Karsai Gergely , Zila Nina , Paulitschke Verena , Cheng Phil F. , Leitner Alexander , Bileck Andrea , Zamboni Nicola , Irmisch Anja , Balazs Zsolt , Tastanova Aizhan , Pascoal Susana , Johansen Pål , Wegmann Rebekka , Mena Julien , Othman Alaa , Viswanathan Vasanthi S. , Wenzina Judith , Aloia Andrea , Saltari Annalisa , Dzung Andreas , Krauthammer Michael , Schreiber Stuart L. , Hornemann Thorsten , Distel Martin , Snijder Berend , Dummer Reinhard , Levesque Mitchell P.
Published: April 2023

S11: Immunohistological analysis of orthologic slice cultures.
Supplementary Table S7 from PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma
Authors: Zhao Mengjie , Li Yanhui , Lu Chenfei , Ding Fangshu , Xu Miao , Ge Xin , Li Mengdie , Wang Zhen , Yin Jianxing , Zhang Junxia , Wang Xiefeng , Ge Zehe , Xiao Hong , Xiao Yong , Liu Hongyi , Liu Wentao , Cao Yuandong , Wang Qianghu , You Yongping , Wang Xiuxing , Yang Kun , Shi Zhumei , Qian Xu
Published: April 2023

Table S7. Clinical information of 95 GBM patients
S3 from TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis
Authors: Anstine Lindsey J. , Majmudar Parth R. , Aponte Amy , Singh Salendra , Zhao Ran , Weber-Bonk Kristen L. , Abdul-Karim Fadi W. , Valentine Mitchell , Seachrist Darcie D. , Grennel-Nickelson Katelyn E. , Cuellar-Vite Leslie , Sizemore Gina M. , Sizemore Steven T. , Webb Bryan M. , Thompson Cheryl L. , Keri Ruth A.
Published: April 2023

Supplemental Figure 3
Supplementary Table3 from USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
Authors: Ren Yidan , Feng Maoxiao , Hao Xiaodong , Liu Xiaoyan , Li Juan , Li Peilong , Gao Jie , Qi Qiuchen , Du Lutao , Wang Chuanxin , Wang Qin , Wang Yunshan
Published: April 2023

Supplementary Table3
Supplementary Table1 from USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
Authors: Ren Yidan , Feng Maoxiao , Hao Xiaodong , Liu Xiaoyan , Li Juan , Li Peilong , Gao Jie , Qi Qiuchen , Du Lutao , Wang Chuanxin , Wang Qin , Wang Yunshan
Published: April 2023

Supplementary Table1
Supplementary Figures from Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer
Authors: Malier Marie , Gharzeddine Khaldoun , Laverriere Marie-Hélène , Marsili Sabrina , Thomas Fabienne , Court Magali , Decaens Thomas , Roth Gael , Millet Arnaud
Published: April 2023

Supplementary figures S1 to S7
Data from Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer
Authors: Malier Marie , Gharzeddine Khaldoun , Laverriere Marie-Hélène , Marsili Sabrina , Thomas Fabienne , Court Magali , Decaens Thomas , Roth Gael , Millet Arnaud
Published: April 2023

Abstract
Colorectal adenocarcinoma is a leading cause of death worldwide, and immune infiltration in colorectal tumors has been recognized recently as an important pathophysiologic event. In this context, tumor-associated macrophages (TAM) have been related to chemoresistance to 5-fluorouracil (5-FU), the first-line chemotherapeutic agent used in treating colorectal cancers. Nevertheless, the details of this chemoresistance mechanism are still poorly elucidated. In the current study, we report that macrophages specifically overexpress dihydropyrimidine dehydrogenase (DPD) in hypoxia, leading to macrophage-induced chemoresistance to 5-FU via inactivation of the drug. Hypoxia-induced macrophage DPD expression was controlled by HIF2α. TAMs constituted the main contributors to DPD activity in human colorectal primary or secondary tumors, while cancer cells did not express significant levels of DPD. In addition, contrary to humans, macrophages in mice do not express DPD. Together, these findings shed light on the role of TAMs in promoting chemoresistance in colorectal cancers and identify potential new therapeutic targets.
Significance:
Hypoxia induces HIF2α-mediated overexpression of dihydropyrimidine dehydrogenase in TAMs, leading to chemoresistance to 5-FU in colon cancers.
Table S2A from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk
Authors: Lou Makayla W.C. , Drummond Ann E. , Swain Christopher T.V. , Milne Roger L. , English Dallas R. , Brown Kristy A. , van Roekel Eline H. , Skinner Tina L. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Table 2A presents the study characteristics of the Mendelian randomization studies
Figure S4C from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk
Authors: Lou Makayla W.C. , Drummond Ann E. , Swain Christopher T.V. , Milne Roger L. , English Dallas R. , Brown Kristy A. , van Roekel Eline H. , Skinner Tina L. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Figure 4C presents dose-response curves for leptin and breast cancer risk, by menopausal status
Figure S4A from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk
Authors: Lou Makayla W.C. , Drummond Ann E. , Swain Christopher T.V. , Milne Roger L. , English Dallas R. , Brown Kristy A. , van Roekel Eline H. , Skinner Tina L. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Figure 4A presents forest plots for leptin and breast cancer risk, by menopausal status
Figure S3B from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk
Authors: Lou Makayla W.C. , Drummond Ann E. , Swain Christopher T.V. , Milne Roger L. , English Dallas R. , Brown Kristy A. , van Roekel Eline H. , Skinner Tina L. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Figure 3B presents the funnel plot from the meta-analysis of IL-6 and breast cancer risk
Figure S3A from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk
Authors: Lou Makayla W.C. , Drummond Ann E. , Swain Christopher T.V. , Milne Roger L. , English Dallas R. , Brown Kristy A. , van Roekel Eline H. , Skinner Tina L. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Figure 3A presents forest plots for IL-6 and breast cancer risk, by menopausal status
Figure S2B from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk
Authors: Lou Makayla W.C. , Drummond Ann E. , Swain Christopher T.V. , Milne Roger L. , English Dallas R. , Brown Kristy A. , van Roekel Eline H. , Skinner Tina L. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Figure 2B presents forest plots for TNF-alpha and breast cancer risk, excluding studies where exogenous hormone use status was unknown
Figure S1E from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk
Authors: Lou Makayla W.C. , Drummond Ann E. , Swain Christopher T.V. , Milne Roger L. , English Dallas R. , Brown Kristy A. , van Roekel Eline H. , Skinner Tina L. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Figure 1E presents the funnel plot from the meta-analysis of CRP and breast cancer risk
Table S2 from High-Throughput Peptide Arrays Identify Potential Diagnostic Autoantibody Signatures in Early-Stage Lung Adenocarcinoma
Authors: Luo Rongrong , Zhong Pei , Li Xiying , Cai Juan , Tao Yimin , Xiong Bangzhu , Zheng Hancheng , Zhang Zhishang , Tang Le , Yao Jiarui , Li Yingrui , Shi Yuankai , Han Xiaohong
Published: April 2023

Comparisons of positive rate between differential autoantibody signatures and tumor biomarkers in Early-LUAD.
Figure S6 from High-Throughput Peptide Arrays Identify Potential Diagnostic Autoantibody Signatures in Early-Stage Lung Adenocarcinoma
Authors: Luo Rongrong , Zhong Pei , Li Xiying , Cai Juan , Tao Yimin , Xiong Bangzhu , Zheng Hancheng , Zhang Zhishang , Tang Le , Yao Jiarui , Li Yingrui , Shi Yuankai , Han Xiaohong
Published: April 2023

Random forest model and GO enrichment. a, Schematic plot of random forest; b, GO terms enriched by the matched proteins of differential peptide probes.
Figure S4 from High-Throughput Peptide Arrays Identify Potential Diagnostic Autoantibody Signatures in Early-Stage Lung Adenocarcinoma
Authors: Luo Rongrong , Zhong Pei , Li Xiying , Cai Juan , Tao Yimin , Xiong Bangzhu , Zheng Hancheng , Zhang Zhishang , Tang Le , Yao Jiarui , Li Yingrui , Shi Yuankai , Han Xiaohong
Published: April 2023

Figure S4. Autoantibodies differentially expressed in plasma samples from patients with Early-LUAD versus BLD. Each boxplot represents an individual peptide signature in the two sample sets.
Table S3 from Deep Transcriptome Profiling of Multiple Myeloma Using Quantitative Phenotypes
Authors: Griffin Rosalie , Hanson Heidi A. , Avery Brian J. , Madsen Michael J. , Sborov Douglas W. , Camp Nicola J.
Published: April 2023

Progression free survival covariates and added predictive values.
Supplemental Figure S7 from Deep Transcriptome Profiling of Multiple Myeloma Using Quantitative Phenotypes
Authors: Griffin Rosalie , Hanson Heidi A. , Avery Brian J. , Madsen Michael J. , Sborov Douglas W. , Camp Nicola J.
Published: April 2023

CoMMpass spectra Hallmark pathway GSEA summary. Gene Set Enrichment Analysis (GSEA) results for all spectra using the Hallmark pathway set from MSigDB v7.4. Only pathways with a significant enrichment (p<0.000025) with at least one spectrum shown. The significance level (intensity) and direction of each enrichment are indicated: green negative normalized enrichment score (NES), purple positive NES. The Hallmark Process Category (Liberzon et al., 2015) for each gene set is shown far left.
Supplemental Figure S6 from Deep Transcriptome Profiling of Multiple Myeloma Using Quantitative Phenotypes
Authors: Griffin Rosalie , Hanson Heidi A. , Avery Brian J. , Madsen Michael J. , Sborov Douglas W. , Camp Nicola J.
Published: April 2023

Time to first line treatment failure spectra score. A) Quantile-quantile plot. B) Gaussian mixture modeling to identify patients at high and low risk of early treatment failure. C) Patients in the spectra high-risk TTF (n = 31, 25 events) had median TTF of 9.2 months compared to low-risk patients (n = 736, 344 events) with median TTF of 32.8 months.
Supplemental Figure S5 from Deep Transcriptome Profiling of Multiple Myeloma Using Quantitative Phenotypes
Authors: Griffin Rosalie , Hanson Heidi A. , Avery Brian J. , Madsen Michael J. , Sborov Douglas W. , Camp Nicola J.
Published: April 2023

Progression free survival spectra score. A) Quantile-quantile plot. B) Gaussian mixture modeling to identify patients at high and low risk of progression. C) PFS high-risk patients (n = 60, 50 events) had median survival of 9.7 months. PFS low-risk patients (n = 707, 342 events) had median survival of 35.7 months.
Supplemental Figure S3 from Deep Transcriptome Profiling of Multiple Myeloma Using Quantitative Phenotypes
Authors: Griffin Rosalie , Hanson Heidi A. , Avery Brian J. , Madsen Michael J. , Sborov Douglas W. , Camp Nicola J.
Published: April 2023

Scree plot of CoMMpass transcriptome dimensions. To limit overfitting in spectra derivation, we used dimension reduction to focus only on the first k spectra (largest k components of variation), selected using a scree test (Cattell, 1966).
Table S6B from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Authors: Swain Christopher T.V. , Drummond Ann E. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Lou Makayla W.C. , Boing Leonessa , Bageley Amy , Skinner Tina L. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Table 6B presents findings of individual randomised cross-over studies
Table S6A from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Authors: Swain Christopher T.V. , Drummond Ann E. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Lou Makayla W.C. , Boing Leonessa , Bageley Amy , Skinner Tina L. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Table 6A presents findings of individual parallel group RCTs
Table S5 from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Authors: Swain Christopher T.V. , Drummond Ann E. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Lou Makayla W.C. , Boing Leonessa , Bageley Amy , Skinner Tina L. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Table 5 presents the outcomes of the meta-regression analysis conducted for IL-6
Table S4 from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Authors: Swain Christopher T.V. , Drummond Ann E. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Lou Makayla W.C. , Boing Leonessa , Bageley Amy , Skinner Tina L. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Table 4 presents the outcomes of the meta-regression analysis conducted for CRP
Table S3C from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Authors: Swain Christopher T.V. , Drummond Ann E. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Lou Makayla W.C. , Boing Leonessa , Bageley Amy , Skinner Tina L. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Table 3C present the risk of bias for the prospective cohort study, using the ROBINS-E
Table S3A from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Authors: Swain Christopher T.V. , Drummond Ann E. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Lou Makayla W.C. , Boing Leonessa , Bageley Amy , Skinner Tina L. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Table 3A presents the risk of bias for randomised controlled and randomised cross-over trials, using the Cochrane Collaboration Tool
Table S2A from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Authors: Swain Christopher T.V. , Drummond Ann E. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Lou Makayla W.C. , Boing Leonessa , Bageley Amy , Skinner Tina L. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Table 2A presents the study characteristics for parallel group RCTs
Table S1 from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Authors: Swain Christopher T.V. , Drummond Ann E. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Lou Makayla W.C. , Boing Leonessa , Bageley Amy , Skinner Tina L. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Table 1 presents the search terminology used in the systematic review
Figure S3B from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Authors: Swain Christopher T.V. , Drummond Ann E. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Lou Makayla W.C. , Boing Leonessa , Bageley Amy , Skinner Tina L. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Figure 3B presents forest plots for physical activity and IL-6, by exercise type
Figure S2B from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Authors: Swain Christopher T.V. , Drummond Ann E. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Lou Makayla W.C. , Boing Leonessa , Bageley Amy , Skinner Tina L. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Figure 2B presents forest plots for physical activity and TNF-alpha, by exercise type
Figure S2A from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Authors: Swain Christopher T.V. , Drummond Ann E. , Milne Roger L. , English Dallas R. , Brown Kristy A. , Lou Makayla W.C. , Boing Leonessa , Bageley Amy , Skinner Tina L. , van Roekel Eline H. , Moore Melissa M. , Gaunt Tom R. , Martin Richard M. , Lewis Sarah J. , Lynch Brigid M.
Published: April 2023

Supplementary Figure 2A present forest plots for physical activity and TNF-alpha, by menopausal status
Table S5 from Diet Quality and All-Cause Mortality in Women with Breast Cancer from the Breast Cancer Family Registry
Authors: Haslam Danielle E. , John Esther M. , Knight Julia A. , Li Zhongyu , Buys Saundra S. , Andrulis Irene L. , Daly Mary B. , Genkinger Jeanine M. , Terry Mary Beth , Zhang Fang Fang
Published: April 2023

Table S5 Shows Hazard Ratios and 95% Confidence Intervals for All-Cause Mortality in Women Diagnosed with Breast Cancer According to DASH and HEI-2015, Stratified by Patient and Treatment Characteristics
Supplementary Table S2 from Neighborhood Socioeconomic Status and Racial and Ethnic Survival Disparities in Oral Cavity and Laryngeal Cancer
Authors: Liu Yupeng , Zhong Lydia , Puram Sidharth V. , Mazul Angela L.
Published: April 2023

Table summarizing 5-year overall survival rate of laryngeal cancer patients.
Supplementary Figure S2 from Neighborhood Socioeconomic Status and Racial and Ethnic Survival Disparities in Oral Cavity and Laryngeal Cancer
Authors: Liu Yupeng , Zhong Lydia , Puram Sidharth V. , Mazul Angela L.
Published: April 2023

KM curve depicting the 5-year overall survival of larynx cavity cancer patients.