bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional investigation of a highly conserved aspartate residue in the anti -cancer drug efflux transport protein MRP1
Authors: Mullins Graeme
Published: April 2021

Multidrug Resistant Protein 1 (MRP1 or ABCC1) belongs to a subclass of ATP-binding cassette (ABC) transporters that export a wide range of metabolites and xenobiotics across the plasma membrane. Increased expression of MRP1 in cancer cells enhances efflux of many anti-cancer agents, giving rise to multidrug resistant tumours. The purpose of this study was to investigate the function of an aspartate (Asp) amino acid that is highly conserved in all MRP-related proteins by mutating it and determining the consequences of doing so. Asp430 lies at the interface of the cytoplasm and a transmembrane helix in the first membrane-spanning domain of MRP1. Previous studies have shown that when Asp430 is mutated, the protein becomes unstable and is degraded.Because this Asp430 is highly conserved in many MRP-related ABC transporters and because structural homology models of human MRP1 predict that Asp430 is in close proximity to Arg433, we hypothesized that a salt bridge between these two a mino acids could be essential for proper folding and stability of the protein during its biosynthesis. Using site -directed mutagenesis, these two amino acids were interchanged to probe the existence of such an interaction. Thus a double mutant where Asp430 was mutated to Arg, and Arg433 was mutated to Asp was created, and the resultant mutant protein (D430R/R433D) was tested for its ability to be detected in mammalian

cells by gel electrophoresis and immunoblotting. Our results show differences between the migration patterns of double and single mutants that are compatible with differences in the

glycosylation levels of MRP1. However the fact that D430R and the R433D mutants don’t share the same migration pattern, together with the variation in migration bet

ween D430 wild type and Supported by CIHR MOP-10519the double mutant D430R/R433D indicate that the possibility of a salt bridge can be discarded.Supported by CIHR MOP-10519
The Evaluation of Heavy Metal Accumulation in Whiting Fish (Merlanguis merlangus euxinus Nordmann, 1840), a Local and Economic Species of the Central Black Sea Region
Authors: Baki Oylum Gökkurt
Published: April 2021

The present study aimed to determine the heavy metal cadmium (Cd), chromium (Cr), nickel (Ni), lead (Pb) and mercury (Hg) accumulations in muscle tissues, gills, gonads, liver, and other visceral organs (liver) of whiting fish (Merlanguis merlangus euxinus Nordmann, 1840) samples obtained by hunting from the Sinop (Black Sea) coasts. The mean cadmium value in muscle tissue, which concerns public health, was found to be 1.07±0.02 Âµg.kg-1, the chromium value was found to be 1.48±0.07 Âµg.kg-1, the nickel value was found to be 1.77±0.14 Âµg.kg-1, the lead value was found to be 5.38±0.29 Âµg.kg-1 while the mercury value was determined only in the gill and could not be determined in organs, and since it was below the limit values declared by international organizations for all metals, it was determined that it would not create adverse effects for human consumption. Also, examining the order of accumulation of heavy metals in tissues and organs from highest to lowest, it was sorted as liver> visceral organ> gill> muscle> gonad for cadmium; visceral organ> gill> muscle> liver> gonad for chromium; visceral organ> gill> liver> muscle> gonad for nickel; gill> visceral organ> liver> muscle> gonad for lead, while the mercury accumulation was detected only in the gill. Also, the data obtained as a result of the analyses made in the gonad is an important determination in terms of the effects of heavy metals on the reproduction of the species, as well as on the continuity of the population. Since the values determined in the other analyzed tissues were below the limit values reported by international organizations, the results showed that they do not pose any threat to human health in terms of workplace and time, type, and determined heavy metals.
The Bifunctional Catalase-Phenol Oxidase of Mycothermus Thermophilum (MtCATPO) Increases the Antioxidant Capacities of its Ortho-Diphenolic Substrates and of Green and Black Tea Extracts
Authors: Söyler Betül , Ögel Zümrüt Begüm
Published: April 2021

Catalase from the thermophilic fungus Mycothermus thermophilus is a bifunctional enzyme with a secondary phenol oxidase activity (CATPO). MtCATPO catalyses the oxidation of catechol, chlorogenic acid, caffeic acid and (+)-catechin to yield mainly dimers, and higher molecular weight oligomers and polymers. The role of this phenol oxidase activity is not known. Here, the antioxidant capacities (AC) of the phenolic substrates in the absence and presence of MtCATPO were compared. The oxidized products displayed enhanced AC reaching a maximum of 2.4-fold with catechol. Other phenol oxidases (laccase and tyrosinase) did not yield AC enhancement to the same extent. MtCATPO-treatment increased AC of green and black tea infusions, as well as water extracts of samples collected from a black tea production line up to 28%. The bifunctional MtCATPO appears to be an important antioxidant enzyme with a wide range of potential applications in the food, neutraceuticals and pharmaceuticals industry.
The Effects of Grape Seed Extract on Insulin, Adiponectin and Resistin Levels in Diabetic Rats
Authors: Söğütlü İnci , Mert Nihat , Mert Handan , Mis Leyla , Yılmaz Halil Cumhur , İrak Kıvanç
Published: April 2021

In this study, the effects of grape seed extract on insulin, adiponectin and resistin levels in diabetic rats were aimed to investigate. Weight of about 300-350g 7-8 weeks 32 female Wistar Albino rats were used. Weight of about 300-350g 7-8 weeks 32 female Wistar Albino rats randomly divided into four groups of eight each: control group (C), group with diabetes (DM), grape seed extract group (GSE), diabetes mellitus and grape seed extract group (DM+GSE). The diabetic group 45 mg/kg single dose of streptozotocin was administered intraperitoneally, and the grape seed extract groups (DM+GSE and GSE) grape seed extract was given orally every day with an intragastric tube for 20 days (0.6 ml/rat). Blood samples were taken from the hearts of rat‘s end of the experiment. The sera obtained were used for insulin, adiponectin and resistin analysis measured via ELISA with commercial kits. The insulin and adiponectin levels of the rats in the diabetes + grape seed extract group were found to be higher than those in the diabetes group. There was no significant change in the resistin level differences between the groups. As a result; It is possible to say that grape seed extract has an increasing effect on insulin level and adiponectin levels of diabetic rats are decreased due to diabetes and it has no significant effect on resistin levels. Detected by the positive effects of grape seed extracts, it may be useful to use for the regulating of the diabetes in human.
Effect of Different Inorganic Substrates on Growth Performance of African Catfish (Clarias gariepinus, Burchell 1822) and Lettuce (Lactuca sativa L.)
Authors: Yeşiltaş Murat , Koçer Mehmet Ali Turan , Sevgili Hüseyin , Koru Edis
Published: April 2021

Lettuce (Lactuca sativa L.) and African catfish (Clarias gariepinus) were preferred to grow in aquaponics due to their high and fast productivity growth. However, limited research was conducted on the impact on different inorganic substrates‘ growth performance in aquaponics. In this study, lettuce‘s growth performance was determined in four different kinds of inorganic substrates in Nutrient Film Technique (NFT) aquaponics by measuring final weight, daily growth rate, stem diameter, plant and root lengths, leaf number per plant and shoot/root ratio. Polyester fiber, rock wool, zeolite, and gravel were used as inorganic substrate materials. A constant flow rate of 0.3 L/min was maintained using with a submersible pump motor. At the end of the study, the African catfish‘s feed conversion ratio was estimated to be 0.66, while the specific growth rate (SGR) was 2.3%. Total lettuce yields for polyester fiber, rock wool, zeolite and gravel were obtained as 5.072,22 kg/m2, 4.934,03 kg/m2, 6.067 kg/m2, and 5.382,64 kg/m2 respectively. There were statistically significant differences for daily growth rate between the inorganic substrates that the significantly highest values were recorded in the zeolite. The results revealed that initial plant length and shoot/root ratio were the significant factors on the growth performance for lettuce in aquaponic system tested. The best lettuce yield performance was observed in zeolite substrate but, economically available option was found as gravel for hydroponic troughs.
Physical, Bioactive and Textural Properties of Oleaster (Elaeagnus angustifolia L.) Fruit from Different Locations in Turkey
Authors: Simsek Meric , Sufer Özge
Published: April 2021

The objective of this study was to evaluate the physical, bioactive and textural properties of oleaster fruits grown in different locations of Turkey. The oleaster fruits were obtained from Aksaray, Niğde and İzmir cities and their crumb and crust parts were analyzed individually and freshly. In terms of color, the crust and crumb of oleaster fruits from İzmir had the darkest color with L* values of 46.81 ± 4.06 and 78.91 ± 4.97 among all tested fruits from different locations, respectively. Total of phenolic (TP), flavonoid (TF) and tannin (TT) content (C) and as well antioxidant activities (AA) of oleaster fruits were determined for the crust and crumb of oleaster fruits. The highest TPC (22.30±1.75 mg gallic acid equivalent/g DM), TFC (16.24±1.49 mg catechin equivalent/g DM) and AA (14.05±0.55 Î¼mol trolox equivalent/g DM) by DPPH were found in the crust of Aksaray oleaster fruits. In addition, the crumb of Aksaray oleaster fruit had the highest TPC (16.44±1.67 mg gallic acid equivalent/g DM) among the crumbs of oleaster fruits from different locations. Furthermore, there was no significant difference among the texture of crust and crumb of oleaster fruits obtained from different locations. Results showed the growing location of oleaster fruits had a significant influence on the physical and bioactive properties of fruits. Also, this study indicated that oleaster fruits were rich in bioactive compounds; therefore, they could be incorporated into foods to design functional foods.
Conselho municipal de educação: análise do princípio da gestão democrática nas legislações do município de São José de Ribamar/MA
Authors: Gomes Brenda Cristina Ferreira , Pimenta Janaina de Araujo , Cardozo Maria José Pires Barros
Published: April 2021

O presente artigo tem por objetivo analisar o quadro normativo relativo à gestão democrática da educação. Para tanto, realizou-se pesquisa bibliográfica, a partir da leitura de autores como Bordignon (2009), Cury (2002; 2000) e Peroni (2008), seguida de pesquisa documental com base na análise das legislações do município de São José de Ribamar - MA. Constatou-se que, embora o princípio de gestão democrática seja preconizado como fundamento que sustenta a organização da educação na esfera local, esse tipo de gestão depara-se com dificuldades para ser materializado. O limite que se impõe para a concretização ocorre por meio das normas que não reconhecem os princípios democráticos e não mencionam mecanismos que facilitem ações voltadas para a efetivação da gestão democrática.
Oportunidades e desafios no ensino superior: experiências de universitários de camadas populares da Universidade Federal de Ouro Preto
Authors: Pena Mariza Aparecida Costa , Coutrim Rosa Maria da Exaltação , Matos Daniel Abud Seabra
Published: April 2021

Esse artigo apresenta resultados de entrevistas com universitários cotistas, de baixa renda, ingressantes no início de 2013 em cursos prestigiosos da Universidade Federal de Ouro Preto. Para as entrevistas foram selecionados seis estudantes de baixa renda, pertencentes aos cursos de Medicina, Direito e Engenharia Civil. À luz da Sociologia da Educação, buscou-se nos relatos, compreender as condições de acesso e permanência, e conhecer as experiências, oportunidades e desafios dos cotistas de baixa renda na graduação. Os depoimentos revelaram que, embora enfrentem dificuldades financeiras, acadêmicas e de sociabilidade principalmente no início do curso, esses jovens apresentam disposições que culminam em oportunidades de crescimentos acadêmico, pessoal e profissional.
Valorizando a manifestação político-religiosa e cultural da Associação Terno do Congo Nossa Senhora do Rosário em Areado-MG
Authors: Silva Natalino Neves da , Costa Ana Márcia da Silva
Published: April 2021

Este texto é resultado de uma pesquisa de Iniciação Científica que integrou o projeto UBUNTU/NUPEAAs – Núcleo de Estudos Africanos, Afro-brasileiros e da Diáspora – da Secretaria de Estado de Educação de Minas Gerais (SEE-MG), realizada no ensino médio em uma escola estadual, localizada no município de Areado, no Sul de Minas Gerais. Buscou-se investigar como a história e cultura da população negra na região são valorizadas por meio do trabalho realizado pela Associação Terno do Congo Nossa Senhora do Rosário. A perspectiva da abordagem da história oral norteou a realização metodológica do estudo. Os resultados alcançados revelam à importância de se trabalhar a valorização da cultura afro-brasileira com os(as) estudantes inseridos nesse nível de ensino.
Using oral food challenges to provide clarity and confidence when diagnosing food allergies
Authors: Greiwe Justin
Published: April 2021

A verified food allergy can be an impactful life event that leads to increased anxiety and measurable effects on quality of life. Allergists play a key role in framing this discussion and can help alleviate underlying fears by promoting confidence and clarifying safety concerns. Correctly
diagnosing a patient with an immunoglobulin E (IgE) mediated food allergy remains a nuanced process fraught with the potential for error and confusion. This is especially true in situations in which the clinical history is not classic, and allergists rely too heavily on food allergy testing
to provide a confirmatory diagnosis. A comprehensive medical history is critical in the diagnosis of food allergy and should be used to determine subsequent testing and interpretation of the results. Oral food challenge (OFC) is a critical procedure to identify patients with an IgE-mediated
food allergy when the history and testing are not specific enough to confirm the diagnosis and can be a powerful teaching tool regardless of outcome. Although the safety and feasibility of performing OFC in a busy allergy office have always been a concern, in the hands of an experienced and
trained provider, OFC is a safe and reliable procedure for patients of any age. With food allergy rates increasing and analysis of recent data that suggests that allergists across the United States are not providing this resource consistently to their patients, more emphasis needs to be placed
on food challenge education and hands-on experience. The demand for OFCs will only continue to increase, especially with the growing popularity of oral immunotherapy programs; therefore, it is essential that allergists become familiar with the merits and limitations of current testing modalities
and open their doors to using OFCs in the office.
Learning early about peanut-triggered food protein‐induced enterocolitis syndrome
Authors: Freeman Catherine M. , Murillo Juan Carlos , Hines Brittany T. , Wright Benjamin L. , Schroeder Shauna R. , Bauer Cindy S.
Published: April 2021

Background: Food protein‐induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E mediated food allergy that typically presents with repetitive emesis and may be associated with lethargy, marked pallor, hypotension, hypothermia, and/or diarrhea. Although many
foods are known to cause FPIES, peanut-triggered FPIES is emerging due to changes in the feeding practice guidelines, which recommends early peanut introduction in infants. Objective: We aimed to characterize peanut-triggered acute FPIES cases in our pediatric population
and to describe their attributes, treatment, and outcomes. We hypothesized that increases in the incidence of peanut-triggered FPIES coincided with implementation of the guidelines for early peanut introduction. Methods: A retrospective chart review was conducted of pediatric
patients who presented to Phoenix Children’s Hospital Emergency Department and subspecialty clinics during a 6-year period (January 2013 to September 2019). Results: Thirty-three cases of patients with acute FPIES were identified, five of which were peanut triggered.
In those patients with peanut-triggered FPIES, the median age for peanut introduction was 7 months (range, 5‐24 months). Two patients had positive peanut skin-prick test results. All five cases were identified in the past 2 years (2018 to 2019). No peanut-triggered reactions were documented
in the preceding 4-year period (2013 to 2017). Conclusion: Peanut may be an emerging trigger of acute FPIES, coinciding with an earlier introduction of peanut in the infant diet after implementation of the new addendum guidelines for the prevention of peanut allergy. Oats
and rice were the most common triggers of acute FPIES in our cohort. Further study will help clarify the significance and reproducibility of these findings.
Adverse reactions to food additives
Authors: Babbel Justin , Ramos Courtney , Wangberg Hannah , Luskin Kate , Simon Ronald
Published: April 2021

Food additives are naturally occurring or synthetic substances that are added to food to modify the color, taste, texture, stability, or other characteristics of foods. These additives are ubiquitous in the food that we consume on a daily basis and, therefore, have been the subject
of much scrutiny about possible reactions. Despite these concerns, the overall prevalence of food additive reactions is 1‐2%, with a minority of the wide variety of symptoms attributed to food-additive exposure being reproduced by double-blind placebo controlled challenges. Reactions
can be broadly classified into either immunoglobulin E (IgE)- and non‐IgE-mediated reactions, with natural additives accounting for most IgE-mediated reactions, and both natural and synthetic additives being implicated in the non‐IgE-mediated reactions. Reactions that include
asthma exacerbations, urticaria and/or angioedema, or anaphylaxis with ingestion of a food additive are most deserving of further allergy evaluation. In this article, we discussed the different types of adverse reactions that have been described to various food additives. We also reviewed
the specifics of how to evaluate and diagnose a food additive allergy in a clinic setting.
Intervenções farmacêuticas e seus desfechos em portadores de HIV/AIDS em atendimento de média complexidade
Authors: Chaves Jorgete Carneiro , Lo Prete Ana Cristina , Soler Orenzio , Ribeiro Carolina Heitmann Mares Azevedo
Published: April 2021

Objetivo: Investigar evidências sobre tipos de intervenções, dando ênfase às intervenções farmacêuticas, e seus respectivos desfechos clínicos, epidemiológicos, de acesso, humanístico e econômicos em portadores de HIV/Aids em atendimento de média complexidade. Métodos: Revisão sistemática com estratégia de busca nos estudos publicados nas bases Cochrane Library, Epistemonikos, Health Evidence, Health Systems Evidence, Biblioteca Virtual de Saúde e Google Scholar; incluindo Medical Subject Headings (MeSH) e Descritores em Ciências da Saúde (DeCS), incluindo os domínios “Pharmaceutical attention”, “Pharmaceutical Care”, “Pharmaceutical Interventions”, “Pharmaceutical Services”, “HIV/AIDS”, “Medium Complexity Attention” e “Medium Complexity Care”, sendo adaptada para as distintas bases eletrônicas, utilizando-se dos operadores booleanos OR e AND. Resultados: Há evidências de que as intervenções farmacêuticas profissionais, financeiras, governamentais e multifacetadas, melhoram os desfechos clínicos, epidemiológicos, de acesso e equidade, humanístico e econômicos em portadores de HIV/Aids em atendimento de média complexidade. Considerações finais: Diversas intervenções farmacêuticas ao portador de HIV/Aids se mostraram importantes na melhora de desfechos clínicos, epidemiológicos, humanísticos e de acesso e equidade, tendo assim o cuidado farmacêutico se mostrado importante para fortalecer as estratégias do uso racional de medicamentos e promovendo a melhoria da qualidade de vida do paciente.
Diferentes protocolos de desinfecção do alginato contaminado com C. albicans
Authors: Gomes Aghata Kelma Palacio , Garcia Camila Alves , Juca Hellen Martins , Santos Steffani Vasconcelos , Pontes Karina Matthes de Freitas , Carvalho Bruna Marjorie Dias Frota de
Published: April 2021

Objetivo: Avaliar a eficácia de diferentes métodos de desinfecção de alginato contaminado com Candida albicans (C. albicans) através do uso de ácido peracético 0,2%, alecrim-pimenta (Lippiasidoides cham.), digluconato de clorexidina 2% e hipoclorito de sódio 1%. Métodos: Biofilmes de C. albicans ATCC 10231 foram desenvolvidos por 48 h. Na sequência, discos de alginato (Hydrogum 5) foram contaminados com C. albicans por 3 minutos sendo submetidos à desinfecção por pulverização (spray) por 10 min, exceto pelos discos dos grupos controle (apenas contaminação) ou de lavagem inicial. A quantificação celular foi realizada após o tempo de contaminação imediata e após 5 dias. Os dados foram submetidos à análise de variância (ANOVA) seguido do teste de Tukey (α=0,05). Resultados: Os discos apenas contaminados apresentaram o maior crescimento de C. albicans na análise imediata e tardia (p<0,05). Os discos apenas com lavagem inicial apresentaram maior crescimento de microrganismos em relação aos que foram desinfetados, independente do tempo de análise (p<0,05). Quanto aos discos desinfetados, não houve crescimento de microrganismos, independente do agente utilizado e tempo de análise (p>0,05). Conclusão: O sprayde ácido peracético, alecrim-pimenta, digluconato de clorexidina e hipoclorito de sódio apresentaram, portanto, poder fungicida na desinfecção de moldes de alginato.
Câncer de colo uterino e a infecção pelo HPV: consequências da não adesão aos métodos de prevenção
Authors: Rodrigues Laís Guedes , Santos Karine Brito Matos , Martins Ana Carolina da Silva Soares , Fagundes Bruna Lorena Silva , Oliveira Valeska Cardoso , Gomes Maria Cecília Ataíde , Sousa Ravena Cristina Silva de
Published: April 2021

Objetivo: Identificar se a vacinação contra o HPV é acessível para o público-alvo e avaliar se os métodos para diagnóstico precoce se aplicam à realidade da população. Métodos: A pesquisa caracteriza-se como uma revisão integrativa de literatura que utilizou como ferramentas de busca as seguintes bases de dados: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), ScientificElectronic Library Online (SCIELO) e Medical Literature Analysis and Retrieval System Online (MEDLINE). Os Descritores em Ciências da Saúde (DECS) utilizados para busca foram: “câncer de colo uterino, Papilomavírus humano, infecção e vacinação”. Resultados: Observou-se que o câncer cervical é o terceiro mais frequente na população feminina e quarta causa mais comum de morte entre as mulheres no Brasil. A infecção pelo HPV acontece principalmente em jovens após o início da vida sexual e estima-se que 660 milhões de pessoas no mundo já tiveram contato com o vírus. Considerações finais: Este estudo é de fundamental importância, pois irá garantir embasamento para a comunidade científica e acadêmica acerca da falta de adesão das mulheres na realização de exames preventivos e falta de informação quanto à importância da vacinação contra o HPV para a prevenção do câncer, o que diminui a taxa de vacinação.
PENGARUH ARUS KAS OPERASI DAN LABA BERSIH TERHADAP HARGA SAHAM SYARIAH PADA PERUSAHAAN YANG TERDAFTAR DI JAKARTA ISLAMIC INDEX PERIODE 2017-2019
Authors: Nenden Ratna Ayu  , Wirman
Published: April 2021

Penelitian ini bertujuan untuk mengetahui pengaruh arus kas operasi dan laba bersih terhadap harga saham syariah pada perusahaan yang terdaftar di Jakarta Islamic Index periode 2017-2019. Jenis penelitian yang digunakan yaitu penelitian kuantitatif. Metode analisis yang digunakan pada penelitian ini yaitu analisis regresi linier berganda. Hasil penelitian secara parsial hanya laba bersih yang berpengaruh terhadap harga saham syariah sedangkan arus kas operasi tidak berpengaruh terhadap harga saham syariah pada perusahaan yang terdaftar di Jakarta Islamic Index (JII) periode 2017-2019. Secara simultan arus kas operasi dan laba bersih berpengaruh terhadap harga saham syariah pada perusahaan yang terdaftar di Jakarta Islamic Index (JII) periode 2017-2019.
Literasi Digital Bagi Siswa Sekolah Menengah Pertama Aisyiyah Muhammadiyah 3 Malang
Authors: Qur'ani Hidayah Budi , Anggraini Purwati
Published: April 2021

Masa remaja merupakan masa peralihan dari masa kanak-kanak hingga dewasa. Masa remaja biasanya diikuti dengan proses penemuan diri. Dalam hal ini, biasanya remaja ingin mencari tahu sesuatu yang tidak mereka ketahui, ingin keberadaannya diperhatikan, dan cenderung lebih bergaul dengan teman sebayanya. Perkembangan teknologi saat ini juga sangat mempengaruhi perkembangan remaja. Setiap siswa memiliki satu perangkat yang dapat digunakan untuk berkomunikasi dan mengakses berbagai informasi yang dapat mendukung pembelajarannya. Oleh karena itu, diperlukan bantuan literasi digital bagi siswa sekolah menengah pertama.  Pengabdian ini dilakukan melalui tiga tahapan, diantaranya tahap persiapan, tahap pelaksanaan, dan tahap refleksi. Pada tahap persiapan terdiri dari koordinasi dengan pihak sekolah dan koordinasi dengan pendamping siswa. Tahap pelaksanaan terdiri dari pemberian materi, diskusi, pendampingan siswa, dan produk siswa. Kemudian tahap refleksi terdiri dari hal-hal yang dapat diambil dari kegitan pendampingan literasi digital. Kegiatan pengabdian ini dilaksanakan di SMP Aisyiyah Muhammadiyah 3 Malang dengan melibatkan 12 siswa kelas 7 dan 8. Karena kondisi masih pademi Covid-19, sehingga metode pada pengabdian ini dilakukan secara daring melalui Whatsapp grup dan pembimbingan melalui video call. Penggunaan aplikasi Whatsapp dipilih karena siswa tidak mengalami kesulitan dan sinyal dapat stabil. Setelah siswa diberi bimbingan, siswa dapat membuat postingan pada media sosial dengan kreatif dengan memanfaatkan media yang ada.
Pelatihan TPACK (Technological, Pedagogical, Content Knowledge) Bagi Guru Bahasa Inggris di Kabupaten Karawang Jawa Barat
Authors: Pahlevi Muhammad Reza , Ridwan Iwan , Kamil Acep Bahrum
Published: April 2021

Isu penggunaan teknologi dalam bidang pendidikan khususnya pengajaran tidak dapat dihindari apalagi dalam masa Pandemi Covid-19 dimana pembelajaran dilaksanakan secara daring. Bagaimanapun pembelajaran daring masih dipahami dan dilaksanakan dengan menekankan penggunaan platform tanpa diintegrasikan sisi pedagogi dan materi ajarnya. Sehingga kegiatan pembelajaran daring belum melibatkan siswa secara aktif dalam pembelajaran daring yang berisi teknologi, pedagogi serta materi ajar (TPACK). Oleh karena itu, pengabdian kepada masyarakat ini bertujuan untuk membantu guru-guru bahasa Inggris dalam mengintegrasikan penggunaan teknologi, pedagogi serta materi ajarnya. Partisapan pengabdian ini adalah guru bahasa Inggris di Karawang. Pelaksaaan pelatihan ini dilakukan dengan memberikan pelatihan terkait integrasi TPACK yang terdiri dari 3 materi yaitu integrasi TPACK dalam lesson plan, TELL in language learning & teaching, dan reflective practice and exploratory practice within Tesol teachers. Setelah mengikuti pelatihan para guru bahasa Inggris dapat membuat RPP dengan integrasi TPACK, mampu mempraktikan TPACK dalam pembelajaran serta melakukan refleksi setelah pembelajaran. Dapat disimpulkan bahwa pelatihan TPACK membantu guru mengintegrasikan baik penggunaan teknologi, pengajaran serta materi ajar dalam pembelajaran.
Workshop Peran E-Commerce Terhadap UMKM di Purbalingga
Authors: Subagio Indra Sukma , Saraswati Esti , Chandra Sari Kartika Dwi
Published: April 2021

Salah satu masalah yang dialami penggiat UMKM di RKB Purbalingga adalah pemasaran produk yang kurang maksimal. Banyak dari mereka sudah menggunakan e-commerce, namun tidak serta merta membuat penjualan meningkat. Tujuan pengabdian masyarakat adalah untuk meningkatkan pengetahuan penggiat UMKM RKB Purbalingga tentang peran e-commerce dalam meningkatkan kinerja. Metode pengabdian yang dilakukan adalah dengan melakukan workshop tentang peran e-commerce terhadap kinerja UMKM. Kegiatan pengabdian masyarakat ini dilaksanakan pada hari Selasa 29 Desember 2020 pukul 09.00-01.00 WIB. Penggunaan pretest dan posttest dilakukan untuk mengukur keberhasilan dari kegiatan ini. Terdapat peningkatan pemahaman sebesar 28% setelah dilakukan perbandingan antara pretest dan posttest, yang berarti bahwa penggiat UMKM di Purbalingga semakin memahami bagaimana e-commerce dapat meningkatkan omzet usaha mereka.
PKM Penanggulangan Hama Kutu Kebul Pada Cabai Rawit Menggunakan Perangkap Likat Kuning di Desa Ayuhula Kabupaten Gorontalo
Authors: Sirajuddin Zulham , Adriani Evie
Published: April 2021

Hama kutu kebul merupakan salah satu persoalan yang cukup sering terjadi di Kabupaten Gorontalo. Minimnya pengetahuan petani cabai rawit mengenai hama kutu kebul merupakan salah satu sebab banyaknya hama kutu kebul yang menyerang tanaman cabai rawit maupun hortikultura lainnya. Fokus utama kegiatan ini adalah menjawab persoalan kutu kebul pada cabai rawit melalui pemantauan secara partisipatif melalui pendekatan citizen science. Tujuannya adalah untuk meningkatkan skill dan pengetahuan petani mengenai pemantauan, pencegahan, serta pengendalian hama kutu kebul pada cabai rawit. Kegiatan ini menggabungkan dua aspek, dimana aspek pertama adalah kegiatan peningkatan kemampuan petani dalam pemantauan, pencegahan, dan pengendalian hama kutu kebul, dan aspek kedua yaitu pemantauan partisipatif berbasis citizen science. Kegiatan ini terlaksana dalam bentuk pelatihan tiga sesi, dimana sesi-1 yaitu mengenai pengenalan hama kutu kebul termasuk ciri-ciri serta penanggulangannya. Lalu pada sesi-2, yaitu praktek pembuatan dan pemasangan alat perangkap yellow sticky trap, dimana petani mempelajari cara membuat perangkap hama kutu kebul. Kemudian pada sesi-3, peserta belajar mengenai prosedur field work, yakni pengamatan, pencatatan, serta input data. Kegiatan ini memberikan pemahaman kepada petani mengenai pentingnya penggunaan perangkap kuning, serta keterampilan kepada petani agar dapat membuat dan menggunakan perangkap kuning sehingga mengurangi serangan hama. Sebelum kegiatan, petani belum mengetahui bahwa mereka dapat membuat sendiri perangkap sederhana dengan menggunakan bahan yang mudah ditemukan disekitar dan memberikan dampak yang baik bagi tanaman mereka. Setelah kegiatan ini, petani menyadari pentingnya pemantauan hama dan juga memahami cara pembuatan perangkap untuk menanggulangi hama kutu kebul sehingga hasil panen dapat dimaksimalkan.
Pembelajaran Edukatif yang Asyik di Masa Pandemi
Authors: Sumarni Ria Asep , Kumala Siti Ayu , Widiyatun Fita -
Published: April 2021

Permainan edukatif yang asyik salah satunya adalah kartu domino dan Uno Stacko. Kedua permainan ini merupakan permainan yang sangat mudah untuk dipelajari dan dimainkan. Pada umumnya, kartu domino berisikan dua bagian yang dipisahkan oleh garis tengah dan mempunyai beberapa jumlah lingkaran yang menunjukkan angka pada kartu tersebut. Tujuan dari pengabdian masyarakat ini adalah mengenalkan permainan kartu domino dan Uno Stacko dengan materi fisika. Di setiap kartu domino mempunyai pasangan yang berisi tentang materi pelajaran, dalam permainan ini kita bermain untuk mencari pasangan dengan materi yang sama. Sedangkan pada Uno Stacko dilengkapi dengan pertanyaan materi pelajaran, dimana saat kita memainkannya kita harus menjawab pertanyaan pada balok Uno Stacko tersebut. Metode Pengabdian masyarakat ini adalah memberi pelatihan pengenalan, pembuatan dan cara menggunakan permainan edukatif melalui webinar kepada MGMP Fisika Kabupaten Lebak. Hasil dari pengabdian kepada masyarakat ini adalah para peserta webinar pelatihan dapat membuat sendiri dan memberikan pengalaman permainan edukatif kepada para siswa meskipun dalam situasi pandemi Covid 19 yang mengharuskan pembelajaran secara daring. Adanya permainan edukatif yang asyik ini bisa dilakukan di rumah dengan bermain sambil belajar. Sehingga pembelajaran akan lebih menarik dan tidak membosankan.
SEPARATION AGREEMENT ASSET FOR INDONESIAN CITIZENS MARRIED ABROAD
Authors: Arwinilita Bella , Anggraini Siti , Wardana Dwi Wisnu , Hermawan Asep , Widiyoko Setiawan
Published: April 2021

Legal protection in agreements on the separation of assets in marriage between Indonesian citizens and foreign citizens as well as analyzing the authority of a notary in making an agreement on the separation of assets in marriage between Indonesian citizens. and foreign nationals. This research uses empirical normative research. The approach method used is a statutory approach, conceptual approach and case approach. Based on the research results, it can be concluded that the making of a marriage contract can provide legal protection for the party who made it. The agreement deed made in the notary can be used as written evidence in court in case of problems at a later date. Based on Article 1868 of the Civil Code and notary authority in Article 15 of the notary office law, it is stated that notaries have the authority to make authentic deeds related to all agreements. Notaries must be able to provide legal certainty in people's lives because in the deed there is evidence that clearly determines a person's rights and obligations as a legal subject in society. Notary Deed as deed which has perfect evidentiary power makes the position of Notary Deed as the first and main evidence in civil evidentiary law.
LEGAL RESPONSIBILITY OF NOTARY DEEDS FOR ELECTRONIC ARCHIVES
Authors: Syuaib Ani Muhammad , Utama Imam Abdi , Sumartono Teresa Irene , Haryono Haryono , Mucharoroh Mucharoroh
Published: April 2021

Deeds made by notaries as public officials are authentic deeds in accordance with the formulation of Article 1 point (7) of the Law on Notary Office, that notary deeds are authentic deeds made by or before a notary according to the form and procedure stipulated by law. The approach method in this research is juridical normative. Based on the results of data analysis, it can be concluded that the use of electronic archives at least notary deeds has not yet obtained a strong legal basis, so it does not guarantee legal certainty. Legal certainty can be achieved, if there are no provisions that conflict between one law and another. The legal substance in the use of electronic records, at least notary deeds, has not been fully accommodated in the notary office law with the obligation to read the deed in front of witnesses and not meeting these requirements will result in legal sanctions for notaries. the law on information and electronic transactions which is the legal basis for notaries also does not provide an opportunity for electronic deeds by providing limits on notary deeds that are not included in electronic documents / information, so that they cannot be used as valid evidence.
THE NARCOTICS ABUSE TERM WEAKNESSES IN CRIMINAL LAW ENFORCEMENT OF INDONESIA
Authors: Elpina Elpina , Purba Mariah Sonanggok
Published: April 2021

A crime of narcotics abuse has experienced an alarming development, one of which is the increasing factor of narcotics abuse, one of which is the legal vacuum in law enforcement against drug abuse. The approach method used uses a normative juridical approach, the research results obtained are the weaknesses of narcotics criminal law enforcement include: (a) in the formulation of criminal sanctions, namely most of the criminal sanctions in Act No. 35 of 2009 are formulated cumutatively, in the formulation of the most cumulations are between imprisonment and sufficient fines. large, there are no special rules for corporations that do not pay fines, and no specific types of sanctions (criminal / action) are seen for corporations (b) related to the issue of criminal threats, namely: there are offenses that are given a special minimum criminal threat which is If there is a deviation from the Criminal Code system, there are no specific guidelines or regulations for the application of minimum penalties, and there are no specific criminal rules to implement the minimal system can be a problem if there is participation, trial, discourse, recidive, criminal mitigation, expiration, and so on.
NOTARY RESPONSIBILITY FOR ELECTRONIC STORAGE OF NOTARY PROTOCOLS
Authors: Ngadino Ngadino
Published: April 2021

The notary protocol is a state archive that must be kept and guarded by a notary public. Due to security concerns, maintenance costs and the size of space required further electronic storage of notary protocols can be carried out. This legal research uses a normative juridical approach as a result of the absence of norms. The technique of using legal materials used is the card system technique. The results show that the notary protocol that is stored electronically is important to do considering the duties of a notary as a public official who has the task of searching for the public in the field of civil cases so that the state must make rules regarding the storage of notary electronic protocols in its arrangement with Cyber Notary. The mechanism is to use the transfer media in digital form or scanning. The strength of notary protocol evidence stored in the field of civil law only functions as a backup, not as an electronic one which has binding power because it does not meet the requirements for document authenticity as regulated in Article 1 paragraph. 7 of the Amendments to the Law on Notaries and Article 1868 of the Civil Code and in the field of criminal procedural law, namely that it can be evidence to show evidence that shows other evidence.
THE LEGAL PROTECTION WEAKNESSES ON COSTUMERS OF ONLINE SHOP TRANSACTIONS
Authors: Tukinah Ukie
Published: April 2021

Electronic transactions that are practiced in online transactions create unequal bargaining power between businesses and customers. Business actors often use the weak position of customers to get the maximum benefit from customers. This study uses a normative juridical approach. The research results obtained include the weaknesses of law enforcement, both from the Customer Protection Agency and the Indonesian Customers Foundation, arguing that there are factors that cause customer protection conditions in Indonesia to be so alarming: First, there is still an asymmetrical relationship between producers and customers. Second, customers generally do not meet sufficient bargaining power against business actors. Third, the Government in general tends to side with business actors. Fourth, there is no sense of concern from existing law enforcement institutions, both from the Police, Attorney General's Office, and the Court.
SOME NOTES ON A GENERALIZED VERSION OF PYTHAGOREAN TRIPLES
Authors: Casinillo Leomarich F , Casinillo Emily L
Published: April 2021

A Pythagorean triple is a set of three positive integers a, b and c that satisfy the Diophantine equation a^2+b^2=c^2. The triple is said to be primitive if gcd(a, b, c)=1 and each pair of integers and  are relatively prime, otherwise known as non-primitive. In this paper, the generalized version of the formula that generates primitive and non-primitive Pythagorean triples that depends on two positive integers  k and n, that is, P_T=(a(k, n), b(k, n), c(k, n)) were constructed. Further, we determined the values of  k and n that generates primitive Pythagorean triples and give some important results.
Spatial Analysis of Erosion Danger Level at Rambut Watershed Area Tegal District
Authors: Sugiarto Totok Wiji , Wulandari Dyah Ari , Atmojo Pratono Samto
Published: April 2021

Erosion is a series of sedimentation processes associated with weathering, releasing, transporting, and settling grains of earth or earth's crust. As a watershed, watersheds are very vulnerable to erosion and sedimentation problems. This research was aimed to predict the erosion danger level at Rambut Watershed Area based on the Universal Soil Loss Equation Formula, by applying a Geographical Information System analysis. Based on the formula, we used four types of maps, i.e. rainfall, soil, slope, and land cover map. On each map, classification was done to get four to five classes based on a specific factor standard. To get the final result from the erosion danger levels which is categorized into five classes, they are very light, light, moderate, heavy, and very heavy, it is necessary to overlay the four types of maps. The results showed that the erosion danger levels at Rambut watershed area ranged from very light to very heavy, with the percentages of the affected areas are 46.91%; 35.13%; 12.47%; 3.67%; and 1.82% respectively. The very heavy and heavy danger areas covered 356.02 ha. And 717.99 ha. respectively. The results are used as a database to make a good planning watershed area management.

Keywords: Erosion, GIS, overlay, USLE, watershed management, weathering
The Tomatoes and Chilies Type Classifications by Using Machine Learning Methods
Authors: Sabilla Irzal Ahmad , Fatichah Chastine
Published: April 2021

Vegetables are ingredients for flavoring, such as tomatoes and chilies. A Both of these ingredients are processed to accompany the people's staple food in the form of sauce and seasoning. In supermarkets, these vegetables can be found easily, but many people do not understand how to choose the type and quality of chilies and tomatoes. This study discusses the classification of types of cayenne, curly, green, red chilies, and tomatoes with good and bad conditions using machine learning and contrast enhancement techniques. The machine learning methods used are Support Vector Machine (SVM), K-Nearest Neighbor (K-NN), Linear Discriminant Analysis (LDA), and Random Forest (RF). The results of testing the best method are measured based on the value of accuracy. In addition to the accuracy of this study, it also measures the speed of computation so that the methods used are efficient.
Integrating Social Capital and Finansial Capital for Beef Cattle Farmers Economic Solutions in Kediri Regency, East Java Province, Indonesia
Authors: Linawati Linawati , Solikin Nur
Published: April 2021

The culture of mutual cooperation with rural communities is one of the social capital that is still ongoing, especially in running livestock businesses. This study aims to analyze the social capital and financial capital of beef cattle breeders. The research location was chosen in conjunction in Semen District, Kediri Regency. Interviewing and filling out questionnaires are instruments in this descriptive study. The results showed that the social capital of cattle breeders in the medium category, financial capital came from a joint venture (gaduhan system). The conclusion is that the existence of social and financial capital due to the gaduhan system is a solution to economic problems in rural areas. An increase in social capital may have an impact on increasing financial capital.
Increasing Complexity of Cryptographic Using Combination of Hill Cipher and Cipher Block Chaining
Authors: Fauzan Abd Charis , Mafula Veradella Yuelisa
Published: April 2021

Security and confidentiality of documents stored on a computer is an important aspect in the field of computer or information system security. Documents will no longer be useful if they are intercepted or hijacked by unauthorized people, they will even endanger the document owner, if documents containing important information are misused by irresponsible people. Therefore the documents on the computer must be preserved so that they are only accepted and used by interested persons. One of the solutions to prevent eavesdropping of documents is to use cryptography. This study aims to increase cryptographic complexity using a combination of hill cipher algorithms and block chaining cipher modes. The combination of the two methods is expected to be able to cover the shortcomings of each method so that the cryptographic complexity can be increased. The method in this study consists of two stages, namely the document encryption and document decryption stages. The encryption stage is to change the plaintext document into a ciphertext document, on the other hand, the decryption stage is to change the ciphertext document back into a plaintext document. The stages for document encryption include; 1) retrieve plain text messages in the document so that they can be processed by the system (parsing); 2) encryption to convert plaintext documents into ciphertext documents using the hill cipher algorithm; 3) encryption to convert plaintext documents into cipher text documents using cipher block chaining mode. While the methods for decryption are 1) taking the ciphertext message in the document so that it can be processed by the system (parsing); 2) decryption to convert ciphertext documents into plaintext documents using cipher block chaining mode; 3) decryption to convert ciphertext documents into plaintext documents using a hill cipher.
Teachers' Experience of Teaching and Online Learning Via WhatsApp as a Combination of Interactive English Learning media in the Covid-19 Pandemic Era of UNU Lab Elementary School Students in Blitar
Authors: Waluyo Bagus , Purwati Oikurema
Published: April 2021

English learning in elementary schools should be engaging, interactive and fun so that students have an interest and motivation for learning especially in the current Covid-19 pandemic, but in reality, the learning patterns in SD Lab Blitar UNU still do not apply English learning patterns that are interactive and fun online because teachers have not affected the learning model that suits students' needs. They find it difficult to determine the right online media as a learning medium due to locations that do not support using the full online facility. The purpose of this study is that the authors intend to provide solutions in formulating exciting and interactive patterns of English teaching to all teachers and students during the co-19 pandemic under online learning conditions. The author uses a qualitative approach through the case study application and applies self-selection to select audiences and conduct online interviews to retrieve all data in the completeness of the study. The results revealed that Teachers' Experience of Teaching and Online Learning Via WhatsApp could create Interactive English Learning in the Covid-19 Pandemic Era, and the Combination can attract students' interest in learning online.