bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-term safety and activity of NY-ESO-1 SPEAR T cells after autologous stem cell transplant for myeloma
Authors: Stadtmauer Edward A. , Faitg Thomas H. , Lowther Daniel E. , Badros Ashraf Z. , Chagin Karen , Dengel Karen , Iyengar Malini , Melchiori Luca , Navenot Jean-Marc , Norry Elliot , Trivedi Trupti , Wang Ruoxi , Binder Gwendolyn K. , Amado Rafael , Rapoport Aaron P.
Published: July 2019

This study in patients with relapsed, refractory, or high-risk multiple myeloma (MM) evaluated the safety and activity of autologous T cells engineered to express an affinity-enhanced T-cell receptor (TCR) that recognizes a peptide shared by cancer antigens New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and L-antigen family member 1 (LAGE-1) and presented by HLA-A*02:01. T cells collected from 25 HLA-A*02:01-positive patients with MM expressing NY-ESO-1 and/or LAGE-1 were activated, transduced with self-inactivating lentiviral vector encoding the NY-ESO-1c259TCR, and expanded in culture. After myeloablation and autologous stem cell transplant (ASCT), all 25 patients received an infusion of up to 1 × 1010 NY-ESO-1 specific peptide enhanced affinity receptor (SPEAR) T cells. Objective response rate (International Myeloma Working Group consensus criteria) was 80% at day 42 (95% confidence interval [CI], 0.59-0.93), 76% at day 100 (95% CI, 0.55-0.91), and 44% at 1 year (95% CI, 0.24-0.65). At year 1, 13/25 patients were disease progression-free (52%); 11 were responders (1 stringent complete response, 1 complete response, 8 very good partial response, 1 partial response). Three patients remained disease progression-free at 38.6, 59.2, and 60.6 months post-NY-ESO-1 SPEAR T-cell infusion. Median progression-free survival was 13.5 months (range, 3.2-60.6 months); median overall survival was 35.1 months (range, 6.4-66.7 months). Infusions were well tolerated; cytokine release syndrome was not reported. No fatal serious adverse events occurred during study conduct. NY-ESO-1 SPEAR T cells expanded in vivo, trafficked to bone marrow, demonstrated persistence, and exhibited tumor antigen-directed functionality. In this MM patient population, NY-ESO-1 SPEAR T-cell therapy in the context of ASCT was associated with antitumor activity. This trial was registered at www.clinicaltrials.gov as #NCT01352286.
Three-dimensional radiologic–pathologic correlation of medication-related osteonecrosis of the jaw using 3D bone SPECT/CT imaging
Authors: Miyashita Hidetaka , Kameyama Kaori , Morita Mayu , Nakagawa Taneaki , Nakahara Tadaki
Published: July 2019

Objectives:

The aim of this study was to assess a three-dimensional (3D) correlation between preoperative 3D bone single photon emission CT (SPECT)/CT, which allows the visualization of radiotracer uptake on 3D volume-rendered CT images, and histopathological characteristics in the medication-related osteonecrosis of the jaw (MRONJ).

Methods:

We conducted a full histopathological assessment of the resected jaws in four patients with Stage 2 or 3 MRONJ. The pathologic results were classified as follows: necrosis without any tissue vascularity (N + V-), necrosis with both vascularity and acute inflammatory cell infiltration due to bacterial infection (N + V+I+), necrosis with regenerative vasculature but no inflammatory cell infiltration (N + V+I-), and chronic inflammation without massive necrosis (N-V +I+). These classifications were correlated with imaging results.

Results:

The N + V- areas visually represented the area of necrotic bone exposed to the oral cavity and were consistent with defect area of radioisotope uptake in SPECT/CT. The N + V- areas were surrounded by the N + V+I + areas where increased radiotracer uptake was clearly seen. Also, abnormal uptake was found in both of the N + V+I- and N-V +I+ areas. The extensive surgical resections from necrotic core to bloody viable margins were performed in all cases, although one had the recurrence of MRONJ at the margin showing abnormal uptake that histologically represented the N + V+I- area.

Conclusions:

Radiologic–pathologic correlation of MRONJ could be achieved using 3D SPECT/CT. The presence of regenerative vascularity with necrosis or inflammation seemed to determine bone metabolism in MRONJ. The recurrence of MRONJ was observed in one case, and 3D SPECT/CT had preoperatively depicted the recurrence site.
Απόψεις εκπαιδευτικών πρωτοβάθμιας εκπαίδευσης για τον σχολικό εκφοβισμό και για τον ρόλο του διευθυντή στη διαχείρισή του
Authors: Χριστακοπούλου Αικατερίνη Αθανάσιος , Αλεξανδρόπουλος Γεώργιος
Published: July 2019

Ο σχολικός εκφοβισμός είναι ένα παγκόσμιο κοινωνικό φαινόμενο, το οποίο αυξάνεται τα τελευταία χρόνια. Η έρευνα που παρουσιάζεται στο παρόν άρθρο αναλύει τις απόψεις των εκπαιδευτικών και των διευθυντών σχετικά με τον ρόλο που θα πρέπει να διαδραματίσουν οι διευθυντές σχολικών μονάδων, καθώς και ποιες θεωρούνται ότι είναι οι κατάλληλες ενέργειες, προκειμένου να αντιμετωπιστεί. Για τη μελέτη του συγκεκριμένου θέματος ακολουθήθηκε η ποσοτική προσέγγιση. Το δείγμα αποτέλεσαν 108 εκπαιδευτικοί και 42 διευθυντές πρωτοβάθμιας εκπαίδευσης, που εργάζονταν σε σχολικές μονάδες του Δήμου Πάτρας. Εργαλείο συλλογής των δεδομένων ήταν το ανώνυμο ερωτηματολόγιο, ενώ κατά τη στατιστική επεξεργασία αξιοποιήθηκαν τα ακόλουθα κριτήρια: Mann Whitney, Kruskal - Wallis, X2 και Spearman’s rho. Από την ανάλυση των δεδομένων προέκυψε η σπουδαιότητα του ρόλου του διευθυντή για την αντιμετώπιση των περιστατικών σχολικού εκφοβισμού. Επιπλέον, αναδείχθηκε η αναγκαιότητα κατάλληλης εκπαίδευσης και συνεχούς επιμόρφωσης των εκπαιδευτικών σχετικά με το συγκεκριμένο κοινωνικό φαινόμενο. Τέλος, διαπιστώθηκαν σημαντικές διαφορές στα ευρήματα ανάλογα με το εργασιακό καθεστώς των ερωτώμενων, την ειδικότητα και τη θέση στην εκπαίδευση.
Totalitarian Aesthetics of Mass Bodily Display During the 1930s
Authors: Toepfer Karl
Published: July 2019

It is a widespread belief that totalitarian societies signify their ‘total unity’ through spectacles involving the display of large, sectored masses of bodies and the levelling off of differences between individual bodies by exalting the uniformity and mechanized synchronization of dynamic, interconnected groups. This belief owes much to fragmentary images of Nazi rallies in the 1930s. But a closer examination of mass spectacles in totalitarian societies of the 1930s reveals considerable differences in their approaches to the mass display of bodies, and these differences result from the unique goals motivating the totalitarian organization of a society. This article compares strategies of mass display of bodies to create a ‘total unity’ of society in relation to the Ku Klux Klan, Japanese imperialism, Italian Fascism, Communism and Nazi Germany.
Sensitivity Study of a Nonlinear Semi-Active Suspension System
Authors: Hajdu Flóra
Published: July 2019

In this paper the OAT (one-at-a-time) sensitivity analysis of a nonlinear semi-active suspension system is carried out with numerical simulation. A specific property of the system is chosen for measure sensitivity, which can be calculated with numerical simulations easily. Both the sensitivity of the system and the input parameters were examined. The degree of sensitivity was measured with a sensitivity index and based on it sensitivity Fuzzy-sets were established. A simple method to reduce sensitivity of a certain parameter is also proposed.
Crystal structure of (μ2-oxido)-bis(N,N′-o-phenylenebis(salicylideneiminato))diiron(III) — N,N′-dimethylformamide, C47H43Fe2N4O9
Authors: Ya Li , Xiangqing Fang , Junyi Liu , Chi Dong , Liguo Yang
Published: July 2019

C47H43Fe2N4O9, orthorhombic, Pbca (no. 61), a = 24.6961(8) Å, b = 14.0952(5) Å, c = 24.696(3) Å, V = 8596.6(4) Å3, Z = 8, R
gt(F) = 0.0374, wR
ref(F
2) = 0.1209, T = 296(2) K [1–3].
Evaluation of the adhesion performance of latex-starch mixtures to calcium carbonate surfaces
Authors: Hashemi Najafi Seyyed Mohammad , Bousfield Douglas W. , Tajvidi Mehdi
Published: July 2019

A number of studies have reported on the mechanical properties of paper coatings and the influence of various parameters on cracking at the fold. Failure at the pigment-binder interface is important to understand because it likely controls how coating layers fail or crack in different applications and processes. In this study, a model system of a calcium carbonate surface in contact with latex and starch binders was used to evaluate the interfacial bonding performance affecting failure in tensile mode. Samples of calcium carbonate marbles with binder films between them were tested in tensile tests and the results were compared with those of pure binder films. In addition, contact angles of calcium carbonate, latex and starch were measured. The failed surfaces were analyzed using Raman spectroscopy and scanning electron microscopy (SEM). All sample involving the calcium carbonate surface failed at a maximum stress of around 25 % compared to that of pure films. Samples that contained starch exhibited larger maximum stress values than pure latex system. The strain at failure for these samples did not depend on the starch content to a large extent. While Raman results did not indicate any residual latex particles on the adhesively failed surfaces, SEM microscopy confirmed that at least part of the failure was still cohesive because regions of binder were present on the surface.
Penerapan Fungsi Actuating Pesantren dalam Upaya Pembinaan Tahfidz
Authors: Sakinah Nur
Published: July 2019

The purpose of this research is to find out how the implementation of actuating function in the effort of fostering tahfidz in Pesantren Bina Insan Mulia Al-Mawahib. The method used in this research is descriptive method. The data collection technique is through obsevation, interview and documentation study. From this research, it is found that actuating process conducted by Pesantren Bina Insan Mulia Al Mawahib: that is holding recruitment of santri before entering pesantren, implementation of coordination, mobilization and resource allocation, giving motivation, addition of rote, division of tahfidz santri group, giving sanction for santri who do not reach the target, the targeting of memorization, the supervision of tahfidz development, the tahfidz superior program in pesantren, the determination of the target number of memorization in every semester, the supervision of the tahfidz coach towards the students and the development of tahfidz's guidance to the students, the excellent program in memorizing the Quran. the existence of constraints tahfidz builder, supporting factors or supporting santri in memorizing the Quran. Further Efforts made in Pesantren Bina Insan Mulia Al Mawahib in coaching tahfidz against santri for the implementation of tahfidz coaching goes well. The effort always strives to foster tahfidz while maintaining the quality and quantity as well as the method of fostering tahfidz such as (1) Ngaji together, (2) sualan, (3) sima'an (4) tasmi and (5)talaqqi. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana penerapan fungsi actuating dalam upaya  pembinaan tahfidz di Pesantren Bina Insan Mulia Al-Mawahib. Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Adapun teknik pengumpulan datanya adalah melalui kegiatan obsevasi, wawancara dan studi dokumentasi. Dari penelitian ini diperoleh informasi bahwa proses actuating yang dilakukan  pesantren Bina Insan Mulia Al Mawahib: yaitu mengadakan perekrutan  santri  sebelum masuk ke pesantren, pelaksanaan koordinasi, mobilisasi dan alokasi sumber daya,  pemberian motivasi, penambahan hafalan, pembagian kelompok santri tahfidz, pemberian sanksi bagi santri yang tidak mencapai target,  penentuan target hafalan, pengawasan pembinaan tahfidz, program unggulan tahfidz di pesantren, penentuan jumlah target hafalan dalam setiap semester, pengawasan  dari Pembina tahfidz terhadap santri dan pengembangan pembinaan tahfidz terhadap santri, program unggulan dalam menghafal Al Quran. adanya kendala pembina tahfidz,  faktor pendukung  atau penunjang santri dalam menghafal Al Quran. Selanjutnya Upaya-upaya yang dilakukan di Pesantren Bina Insan Mulia Al Mawahib dalam pembinaan tahfidz terhadap santri agar pelaksanaan pembinaan tahfidz berjalan dengan baik. Upaya tersebut senantiasa berupaya untuk  membina tahfidz dengan tetap menjaga kualitas dan kuantitas juga metode dalam pembinaan tahfidz seperti (1) ngaji bersama,(2) sualan,(3)sima’an(4) tasmi dan(5) talaqqi.
Effect of Water Extract Originated from Different Part of Russian Knapweed (Acroptilon repens L.) on Growth of Purslane (Portulaca oleracea L.)
Authors: PIRZAD Alireza , JAMALI Mousa , ZAREH Mohammad Amin , SHOKRANI Fahime
Published: July 2019

To evaluate probable allelopathic effect of water extract originated from different parts of russian knapweed (Acroptilon repens L.) on growth of purslane (Portulaca oleracea L.), a factorial experiment was conducted based on randomized complete block design with three replications at greenhouse condition in 2011. Treatments were water extract concentrations (0, 5, 10, 15 and 20 percent) obtained from different part of russian knapweed (aerial part, flower and root). Results showed the significant effect of extract type on seedling length, and extract concentration on shoot length, root length and seedling length. Interaction effect between extract type and concentration on the ratio of root/shoot length, seedling fresh weight, seedling dry weight and germination percentage was significant, too. Means comparison indicated that the longest root (3.55 cm), shoot (4.65 cm) and seedling (8.20 cm) were obtained from control treatment, reducing with higher concentration of extract. The longest shoot (6.95 cm) belonged to extract originated from russian knapweed flowers. The highest ratio of root/shoot length (0.73), seedling fresh weight (0.61g) and seedling dry weight (0.044 g) belonged to control treatment. In general, increasing of extract concentration caused in reduction of germination and seedling traits. Meanwhile, extracts of aerial part had more sever reducing effect than root and flower extracts.
Molecular Identification and Phylogenetic Relationships of Threadfin Breams (Family: Nemipteridae) Using mtDNA Marker
Authors: RAVITCHANDIRANE Vaithilingam , GEETHA Vaithianathan , RAMYA Vijayan , JANIFER Bilavendiran , THANGARAJ Muthusamy , SUBBURAJ Jayachandran , RAMANADEVI Vellaichamy , GANESAN Takshnamurthy
Published: July 2019

Cytochrome c oxidase-1 gene sequences of mitochondrial genome were analyzed for species identification and phylogenetic relationship among the commercially important Nemipterus species. Sequence analysis of COI gene clearly indicated that all the nine fish species fell into distinct clads, which are genetically distant from each other and exhibited identical phylogenetic reservation. All the COI gene sequences provide sufficient phylogenetic information and evolutionary relationship to distinguish the nine Nemipterus species unambiguously. As per the neighbour-joining (NJ) and maximum likelihood (ML) trees, all the nine species are genetically distant from each other and exhibited identical phylogenetic reservation. Based on the NJ and ML phylogenetic trees N. mesoprion, N. zysron, N. hexodon, N. nematophorus, N. virgatus and N. bipunctatus were closely related with high bootstrap value (97). The overall mean Kimura two parameter (K2P) distances between the nine species was 0.109. The intra species K2P distance was high in N. japonicus (0.069) followed by N. peronii (0.050) and N. mesoprion (0.002). This study proves the use of mtDNA COI gene sequence based approach is an alternative tool for identifying fish species at a faster pace.
RETROSPECTIVE 6 YEARS STUDY OF MATERNAL OUTCOME AFTER CAESAREAN HYSTERECTOMY IN SULAIMANI MATERNITY TEACHING HOSPITAL
Authors: Fattah Chro , Mohamed Shanyar
Published: July 2019

Background 

Caesarean hysterectomy is one of the surgical procedures that performed as a last choice for saving mothers life challenging all obstetricians about the exact management between saving life or saving the fertility with the available resources. 

Objectives 

This study was conducted to determine incidence, associated factors and maternal morbidity and mortality after cesarean hysterectomy.

Patients and Methods

It is a descriptive retrospective study conducted over 6 years from 2012 to 2017 included all caesarean (peripartum) hysterectomies performed in Sulaimani maternity teaching hospital beyond 24 week gestation. File records was used to determine the data regarding the research. We used “IBM SPSS Statistics version 20” for the analysis of the data.

Results

The prevalence of cesarean hysterectomy was 0.56/1000 total deliveries. The ages were between 35-40 years, risk factors of last pregnancy were obesity, grand multiparity, and previous C\S were found in 55%, 65%, and 65% respectively. For antepartum and intrapartum risk factor antepartum hemorrhage and postpartum hemorrhage represented 20% and 30% respectively. Most of their pervious pregnancies delivered by (C/S) and 20% had history of 3 previous C/S, and 25% their pregnancy was complicated by gestational diabetes mellitus. Regarding intraoperative management blood product, B- Lynch suture, internal iliac artery ligation, intrauterine balloon, and recombinant factor 7 used in almost all cases. In follow up cases for 1 year chronic pelvic pain was most frequent complaint in 20% and ovarian cyst was also found in about 25%. 

Conclusion

Prevalence of cesarean hysterectomy incidence was 0.56/1000 total deliveries. The significant risk factors were obesity, grand multiparity, and history of previous C\S sections. Regarding maternal age is not far from the international age related to cesarean hysterectomy.
ACUTE RADIOTHERAPY-INDUCED SKIN REACTIONS: THREE MONTHS CLINICAL OBSERVATION AT A SINGLE INSTITUTE IN KURDISTAN–IRAQ
Authors: Kareem Ranjdar , Saeed Mohammed , Mula-Hussain Layth
Published: July 2019

Background 

Radiotherapy Induced Skin Reactions (RISR) are common side effects of external-beam radiotherapy (EBRT). They can be acute or chronic and may require special attention by the care givers. It is not yet studied in our region. 

Objectives

To observe the clinical manifestations of randomly collected patients, whom will take RT in a single radiation oncology center, over a period of three months post the first RT fraction.

Methods 

Fifty patients with different types of cancers participated, whom have been treated with EBRT for different intentions. Ten sessions of clinical observation applied, started before the 1st EBRT dose and extended to 12th week, using Skin Toxicity Assessment Tool (STAT).

Results

It involved 35 females and 15 males. Full assessment was amenable for 49 patients. Breast cancer patients were half of the cohort. Seventy percent of participants received a total dose of 4001-6000 centyGray (cGy). Ninety four percent got at least one of RISRs ranging from faint erythema 94%, itching 82%, hyperpigmentation 78%, dry desquamation 74%, burning 66%, bright erythema 62%, wet desquamation 58%, tenderness 30%, and ulceration 6%.

Conclusion

Acute RISR is a very common side effect of EBRT in our population. Erythema was the most frequent, while ulceration was the lowest. Total dose was directly proportional to the severity of damage.
COMPARING CORONARY ANGIOGRAPHIC FINDINGS AMONG DIABETIC AND NON-DIABETIC PATIENTS
Authors: Mahwi Taha , Mirza Aram , Abdalwahid Redwan
Published: July 2019

Background 

Diabetes mellitus is worldwide metabolic and vascular problem characterized by hyperglycemia. People with diabetes have a 4-fold-greater risk for having a cardiovascular disease than people without diabetes.

Objectives 

To look at the effect of diabetes mellitus on the number of the coronary vessels involved and the extent of coronary artery disease and the association of different socio-demographic characteristics in respect to diabetic and non-diabetic patients.

Patients and Methods

A cross-sectional observational study was conducted on two hundred patients who were admitted to Sulaimani Cardiac Teaching Hospital between March and September 2018. Half of the cases were diabetic and the other half were non-diabetic.

Results

Among the total of 200 patients involved in the study, 59% were males and 41% were females. Mean age was 60.98±10.60. Average HbA1c% value for DM patients was 8.46±2.10. Coronary angiography results in diabetic patients were positive for more multi vessel disease than non-diabetic patients (53% vs. 39%) (p value = 0.005). Diabetic patients were more likely to be hypertensive than non-diabetic patients (59% vs. 40%) (p value=0.001).

Conclusion

Diabetes mellitus is a risk factor for coronary artery disease and diabetic patients had more extensive CAD, which is comparable to other studies done in different countries.
Мода как механизм формирования социокультурных образцов и стилей поведения. Концепция Г. Блумера
Authors: Сапожникова Виктория Станиславовна
Published: July 2019

В статье показано, что теоретические работы, рассматривающие моду классового общества конца ХIХ — ХХ в., составили научную базу для становления и формирования научной мысли о моде. Автор прослеживает тенденции развития моды и их отражение в культурфилософской и социологической литературе, доказывает, что мода выступает как мощный фактор формирования и трансляции социокультурных образцов.

Значительное внимание в статье уделяется взглядам П. Бурдье, Ж.-Г. Тарда, Э. С. Богардуса, А. Ленгле. Особое значение автор придает работам известного американского социолога Г. Блумера, который в значительной степени пересматривает подход Г. Зиммеля к феномену моды и расширяет трактовку моды как явления, распространяемого на все сферы человеческой деятельности — поведение, искусство, науку. Автор показывает современность взглядов Г. Блумера, который, отказавшись от трактовки моды как механизма классовой дифференциации, сосредоточивается на ее способности выступать в качестве механизма коллективного отбора. Концептуальное положение исследователя о том, что мода формируется не только естественным путем, но и создается искусственно, позволяет автору рассмотреть ряд тенденций в сфере военно-патриотического воспитания, усиливающих патриотические настроения.

В качестве примера разбираются тенденции развития модной одежды в стиле милитари, представленные отечественными торговыми марками и разработанные одним из представителей российской моды — дизайнером В. Юдашкиным. Введение новой военной формы, соответствующей и технологически, и эстетически современным тенденциям, а также представление этой коллекции Верховному главнокомандующему в 2008 г., состоявшей примерно из 70 моделей, привело к подъему патриотических настроений в обществе и существенному улучшению имиджа Российской армии.
Развитие идей о способности субъекта к самостоятельному выбору и современная дискуссия о социальной субъектности
Authors: Дарган Анна Александровна
Published: July 2019

В данной статье осуществляется анализ теоретических концепций социологов Запада и России, посвященных социальной субъектности. Доминантой, определяющей различия данных концепций, является рассмотрение социальной субъектности как качества личности или качества субъекта.

Социальная субъектность как качество личности рассматривается через обладание личностью совокупности социально-психологических характеристик, которые определяют ее способность осуществлять сознательный самостоятельный выбор в поле социальных отношений, выстраивать ценностное отношение к важнейшим сторонам общественной жизни и планировать свою жизненную траекторию (С. И. Григорьев, Л. Д. Демина, Е. Ю. Леонова, О. Ф. Ларионова). Рассмотрение социальной субъектности как качества личности делает возможным его двухуровневую дифференциацию, а также открывает перспективы изучения механизмов формирования определенного типа социальной субъектности. Ведь при таком подходе социальная субъектность может иметь определенное значение как для самого индивида, так и для общества в зависимости от того, какой он сделал ценностный выбор жизненной стратегии самореализации.

Социальная субъектность как качество субъекта имеет другое определение: это способность субъекта быть творцом социальной реальности, выражающаяся в его способности сделать выбор и далее реализовать его в поле социальных отношений (Вал. А. Луков, Ю. А. Зубок, В. И. Чупров, Г. З. Нафикова). В рамках данного подхода социальная субъектность может быть рассмотрена на двух уровнях: индивидуально-личностном уровне и групповом уровне, когда субъектом выступает не отдельный человек, а социальная группа.  В этом случае социальная субъектность определяется двумя детерминантами: внутренними факторами, качествами субъекта, определяющими его способность сделать выбор в поле социальных отношений; внешними условиями, которые позволяют ему реализовать данный выбор.
Polymorphism of genes controlling low level of linolenic acid in lines from VIR flax genetic collection
Authors: Porokhovinova Elizaveta A. , Shelenga Tatyana V. , Matveeva Tatyana V. , Pavlov Andrey V. , Grigorieva Elizaveta A. , Brutch Nina B.
Published: July 2019

Background. Linseed solin varieties were created for nutrition, but the effect of oil fatty acid (FA) composition on other characters is not clear.
Materials and methods. Using 6 inbreeding generations from 26 heterogeneous flax accessions were generated 19 high (HL), 7 medium (ML) and 14 low linolenic (LL) lines. For each lines contents of 5 basic FA: palmitic, stearic, oleic (OLE), linoleic (LIO) and linolenic (LIN); the ratio LIO/LIN, oil iodine number, vegetative period (VP) phases and plants size were evaluated. Development of CAPS marker for LuFAD3A gene was performed using idtdna.com. Sequencing of LIN genes sites was done in the Centre MCT SPBGU and Eurogen.
Results. ANOVA showed significant differences HL, ML and LL groups for PAL, OLE, LIO, LIN, LIO/LIN, IOD. Considerable decrease of LIN, causes asymmetric changes in FA ratio and correlations between them and other traits. Factor analysis revealed the influence of two factors. The first one divided lines according to their LIN level and characters associated with it, the second one according to the VP and OLE. LIN synthesis is controlled by two complementary genes LuFAD3A and LuFAD3B. Sequencing of LuFAD3A gene 1 exon of 6 lines revealed a mutation (G255 A255), resulting in formation of stop codon. Developed developed CAPS-marker confirmed the homozygosity of hybrids between LL (gc-391) and HL lines (gc-65, 109, 121). Descendants of hybrid between gc-109 and gc-391 ripened 8-10 days earlier than gc-391. CAPS markers of LuFAD3B gene revealed differences between HL, ML, LL lines. Sequencing of this gene first exon and the beginning of the second one in 3 lines (1HL, 2LL) showed that this method reveals a mutation in the second restriction site, located in the 2 exon (C6 T6), and causing the replacement Hys Tyr.
Conclusion. Lines from GC have wide variability of FA and other agronomic characters, combination of which will expand the cultivation of solin.
O USO DO FUTEBOL COMO ESTRATÉGIA DE CONTROLE * THE USE OF FOOTBALL AS A CONTROL STRATEGY
Authors: Kupper Agnaldo
Published: July 2019

O caso do futebol é emblemático. Faz-se necessário entender como o brasileiro se apropriou do esporte, como que o tomando das camadas mais abastadas que o introduziram no país. Mesmo com as tentativas de coibição da prática, a apropriação se deu. Nas primeiras décadas do século XX, o movimento operário brasileiro postou-se de forma ruidosa. Apesar da ação repressiva governamental, a nascente burguesia industrial brasileira, inquieta diante das mobilizações sindicais proletárias, teria feito uso de mecanismos menos duros como apoiar e financiar o esporte que caíra nas graças operárias: o futebol.*The case of football is emblematic. It is necessary to understand how the Brazilian took possession of the sport, as if taking it from the more affluent layers that introduced it in the country. Even with attempts to curb practice, appropriation has taken place. In the first decades of the twentieth century, the Brazilian labor movement was noisy. Despite the government's repressive action, the nascent Brazilian industrial bourgeoisie, worried about the proletarian trade union mobilizations, would have made use of less harsh mechanisms such as supporting and financing the sport that had fallen into the workers' graces: soccer.
Synthetic leu-enkefalin analogue prevents activation of neutrophils induced by a bacterial component
Authors: Grebenchikov O. A. , Shabanov A. K. , Kosov A. A. , Skripkin Yu. V. , Yavorovsky A. G. , Likhvantsev V. V.
Published: July 2019

Background: Neutrophil activation is a  mandatory stage and a  sensitive marker of systemic inflammatory response. The development of this condition is associated with subsequent multiple organ failure which is the main indication for the patients stay in the intensive care unit. The search for drugs that could prevent the development of systemic inflammatory response and reduce mortality remains an urgent task of anesthesiology/resuscitation.

Aim: To study the anti-inflammatory effect of dalargin, a synthetic analogue of lei-enkephalin, on human neutrophils in vitro.

Materials and methods: The study was performed on blood neutrophils isolated from 5 healthy donors. A proportion of neutrophils were activated by 10 mkM formil-Met-Leu-Pro (fMLP) and 100 ng/mL lipopolysaccharide (LPS) with subsequent assessment of their activity by fluorescent antibodies to the degranulation markers CD11b and CD66b. Thereafter intact and activated neutrophils were treated with dalargin solution at concentrations of 50 and 100 mcg/mL.

Results: Dalargin at 100 mcg/mL reduced the expression of CD11b molecules on the surface of intact neutrophils by 5.5-fold (p=0.008). On the contrary, LPS at a  dose of 100  ng/mL increased the expression of the same molecules by 46% (p=0.08). The addition of dalargin at 50 mcg/mL to LPS-activated neutrophils reduced the expression of CD11b molecules (p=0.016). The addition of dalargin at 50  mcg/mL to fMLP-activated neutrophils significantly (p=0.008) reduced the expression of CD11b molecules and reversed their expression virtually to the level of the control. The addition of dalargin at 100  mcg/mL to neutrophils activated by fMLP at 10 mkM reduced the expression of CD11b on their surface to a level below the control by 23% (p=0.08).

Conclusion: Dalargin at the studied concentrations has an anti-inflammatory effect on both intact and pre-activated bacterial components of neutrophils, thus inhibiting the process of activation and degranulation in a dose-dependent manner.
Prevention of epileptogenesis as a future strategy for the treatment of epilepsy
Authors: Bragin A. G.
Published: July 2019

Epilepsy affects more than 70  million people worldwide. From 30 to 40%  of the patients are resistant to existing medication. This paper describes the current state of the treatment of epilepsy and proposes a  future approach to preventative treatment at earlier stages of epileptogenesis. For preventative treatment biomarkers are needed that predict the development of epilepsy at its earlier stages. Pathological high frequency oscillations are the only acceptable biomarker of epileptogenesis. However, the main limitation of this biomarker is the necessity of implanting of recording electrodes. The search for noninvasive biomarkers of epileptogenesis is one of the hot topics in epilepsy research. There are two potentially interesting directions in this area: search for inflammatory biomarkers in the peripheral blood and analysis of different parameters of imaging methods. In this paper we present approaches for identification of potential epileptogenesis biomarkers by magnetic resonance imaging. Some of magnetic resonance imaging parameters correlate with the existence of pathological high frequency oscillations, may indirectly reflect ongoing inflammation process in the brain and be potential biomarkers of epileptogenesis.
The microvine, a model to study the effect of temperature on grapevine latent bud development and fruitfulness
Authors: Dias Frederico Alcântara Novelli , Torregrosa Laurent , Luchaire Nathalie , Houel Clea , Pellegrino Anne
Published: July 2019

Aim: The success of inflorescence primordia initiation and differentiation within latent buds (i.e. bud fruitfulness) is a critical issue for grapevine yield sustainability under climate change. The aim of the present study was to track the timing and rate of inflorescence development in latent buds along the cane and to quantify their responses to elevated day/night (D/N) temperatures.Methods and Results: The experiments were conducted under controlled conditions, using the microvine model, which is suitable for establishment in small areas. Two imagery methods for analyzing bud anatomy were assessed: light microscopy and x-ray microtomography. Light microscopy was laborious, but it was the most accurate method for investigating organogenesis in the primordial shoot of the latent bud. In plants grown in a greenhouse (D/N, 25°C/15°C), the number of phytomer primordia in latent buds increased linearly from the apical to the basal buds on the cane. A maximum of six phytomers and two inflorescence primordia were observed beneath the 20th bud position that is, slightly fewer than usually reported with macrovines. The first and second inflorescences started to differentiate at the 14th and 18th bud position, respectively. Temperature increases in the growth chamber (D/N, 20–30°C/15–25°C) only slightly changed the final number of preformed phytomers and the probability of inflorescence primordia differentiation per bud. However, elevated temperature sharply accelerated and thereby shortened development of the latent bud primordial shoot, resulting in differentiation of the first inflorescence primordia straight from the fifth bud position. Based on the spatiotemporal conversion of bud position into thermal time, the first inflorescence started to differentiate 332 growing degree days (°Cd) (or 41 days) after bud emergence at D/N 20°C/15°C, and only 98°Cd (or 5 days) after bud emergence at D/N 35°C/25°C. Finally, the number of preformed phytomers was shown to correlate with primary bud length and cane diameter, independent of temperature. These easily measured variables may be used as indicators of bud developmental stage and potential bud fruitfulness in further studies using the microvine.Conclusions: The microvine appears to be suitable for parameterizing a developmental model of grapevine latent buds under controlled environmental conditions and when evaluating the response to elevated D/N temperatures.Significance and impact of the study: The precise description of the timing and rate of differentiation of phytomers and inflorescences opens new perspectives for understanding the molecular processes underlying the response of bud fruitfulness to environmental constraints.
The Effectiveness of Problem-Based Learning on the Hoax Informations to Improve Students’ Critical Thinking Skills (Related to Some Foods and Beverages)
Authors: Apriyani Tri Dewi , Fadiawati Noor , Syamsuri M. Mahfudz Fauzi
Published: July 2019

The hoax informations that spread through social media had a negative impact on society. Therefore, research had been conducted in Gedongtataan Upper Secondary School No.1  to describe the effectiveness of problem-based learning model on hoax informations in improving students' critical thinking skills. This study was used the matching only pretest-posttest control group design. The sample in this study was the 11th grade of IPA 4 (experimental class) and the 11th grade of IPA 5 (control class) which was obtained by using purposive sampling technique. The results showed that the average n-gain in the experimental and control classes was 0.7 and 0.6, respectively. Based on this, it could be concluded that the problem based learning model on the hoax informations was effective in improving students' critical thinking skills. Keywords: critical thinking skills, hoax informations, problem-based learning.
VNIIMS standard base of in the field of measuring the amount and properties of substance – measurements in chemistry and biology
Authors: Kulyabina E. V. , Vikhrova S. V.
Published: July 2019

The issue of the role of VNIIMS as the leading scientific organization in the field of legal metrology and the leading scientific and practical centre for metrological support of various sectors of the national economy is considered. The paper provides information on the equipment of the institute with standards in the field of physical and chemical measurements. The characteristics of experimental sample of the State Primary Standard of the unit of catalytic activity – katal, characteristics and fields of application of state standards of units of the VNIIMS in the field of physical and chemical measurements are given. The describes the plans of VNNIMS in accordance with the List of Critical Technologies of the Russian Federation, state programs for the development of industries.
Developing a reference material set for the magnetic properties of NdFeB alloy-based hard magnetic materials
Authors: Volegova E. A. , Maslova T. I. , Vas’kovskiy V. O. , Volegov A. S.
Published: July 2019

Introduction The introduction indicates the need for the use of permanent magnets in various technology fields. The necessity of measuring the limit magnetic hysteresis loop for the correct calculation of magnetic system parameters is considered. The main sources of error when measuring boundary hysteresis loops are given. The practical impossibility of verifying blocks of magnetic measuring systems element-by-element is noted. This paper is devoted to the development of reference materials (RMs) for the magnetic properties of hard magnetic materials based on Nd2Fe14B, a highly anisotropic intermetallic compound.

Materials and measuring methods Nd-Fe-B permanent magnets were selected as the material for developing the RMs. RM certified values were established using a CYCLE‑3 apparatus included in the GET 198‑2017 State Primary Measurement Standard for units of magnetic loss power, magnetic induction of constant magnetic field in a range from 0.1 to 2.5 T and magnetic flux in a range from 1·10–5 to 3·10–2 Wb.

Results and its discussion Based on the experimentally obtained boundary hysteresis loops, the magnetic characteristics were evaluated, the interval of permitted certified values was set, the measurement result uncertainty of certified values was estimated, the RM validity period was established and the first RM batch was released.

Conclusion On the basis of conducted studies, the RM type for magnetic properties of NdFeB alloy-based hard magnetic materials was approved (MS NdFeB set). The developed RM set was registered under the numbers GSO 11059–2018 / GSO 11062–2018 in the State RM Register of the Russian Federation.
A method for estimating the certified value uncertainty of a multicomponent reference material
Authors: Migal P. V. , Medvedevskikh S. V. , Firsanov V. A.
Published: July 2019

This paper presents the results of a series of studies aimed at investigating the reference material (RM) of a multicomponent solution. An algorithm for estimating the uncertainty induced by the chemical element content in the RM is proposed taking into account the mass of the measurand in each component of the mixture. The results calculated according to the preparation procedure using the proposed algorithm were confirmed by the Monte Carlo method, while the elemental content in the mixture was confirmed via inductively coupled plasma optical emission spectroscopy. The applicability of weighted mean estimates for characterizing an RM of a multicomponent solution is shown.
Optimizing School Food Supply: Integrating Environmental, Health, Economic, and Cultural Dimensions of Diet Sustainability with Linear Programming
Authors: Eustachio Colombo Patricia , Patterson Emma , Schäfer Elinder Liselotte , Lindroos Anna Karin , Sonesson Ulf , Darmon Nicole , Parlesak Alexandr
Published: July 2019

There is great potential for reducing greenhouse gas emissions (GHGE) from public sector meals. This paper aimed to develop a strategy for reducing GHGE in the Swedish school food supply without compromising nutritional adequacy, affordability, and cultural acceptability. Amounts, prices and GHGE-values for all foods and drinks supplied to three schools over one year were gathered. The amounts were optimized by linear programming. Four nutritionally adequate models were developed: Model 1 minimized GHGE while constraining relative deviation (RD) from observed food supply; Model 2 minimized total RD while imposing stepwise GHGE reductions; Model 3 additionally constrained RD for individual foods to an upper and lower limit; and Model 4 further controlled how ratios between food groups could deviate. Models 1 and 2 reduced GHGE by up to 95% but omitted entire food categories or increased the supply of some individual foods by more than 800% and were deemed unfeasible. Model 3 reduced GHGE by up to 60%, excluded no foods, avoided high RDs of individual foods, but resulted in large changes in food group ratios. Model 4 limited changes in food group ratios but resulted in a higher number of foods deviating from the observed supply and limited the potential of reducing GHGE. Cost was reduced in almost all solutions. An omnivorous, nutritionally adequate, and affordable school food supply, with considerably lower GHGE is achievable with moderate changes to the observed food supply. Trade-offs will always have to be made between achieving GHGE reductions and preserving similarity to the current supply.
Noise Disturbances and Calls for Police Service in València (Spain): a Logistic Model with Spatial and Temporal Effects
Authors: Seguí Lia , Iftimi Adina , Briz-Redón Álvaro , Martínez-Garay Lucía , Montes Francisco
Published: July 2019

The purpose of this paper is to explore the presence of spatial and temporal effects on the calls for noise disturbance service reported to the Local Police of València (Spain) in the time period from 2014 to 2015, and investigate how some socio-demographic and environmental variables affect the noise phenomenon. The analysis is performed at the level of València's boroughs. It has been carried out using a logistic model after dichotomization of the noise incidents variable. The spatial effects consider first and second order neighbours. The temporal effects are included in the model by means of one and two weeks temporal lags. Our model confirms the presence of strong spatio-temporal effects. We also find significant associations between noise incidence and specific age groups, socio-economic status, land uses and recreational activities, among other variables. The results suggest that there is a problem of ``social'' noise in València that is not exclusively a consequence of coexistence between local residents. External factors such as the increasing number of people on the streets during weekend nights or during summer months increase severely the chances of expecting a noise incident.
Characterization and Water Content Estimation Method of Living Plant Leaves Using Terahertz Waves
Authors: Zahid Adnan , Abbas Hasan T. , Imran Muhammad A. , Qaraqe Khalid A. , Alomainy Akram , Cumming David R. S. , Abbasi Qammer H.
Published: July 2019

An increasing global aridification due to climate change has made the health monitoring of vegetation indispensable to maintaining the food supply chain. Cost-effective and smart irrigation systems are required not only to ensure the efficient distribution of water, but also to track the moisture of plant leaves, which is an important marker of the overall health of the plant. This paper presents a novel electromagnetic method to monitor the water content (WC) and characterization in plant leaves utilizing the absorption spectra of water molecules in the terahertz (THz) frequency for four consecutive days. We extracted the material properties of leaves of eight types of pot herbs from the scattering parameters, measured using a material characterization kit in the frequency range of 0.75 to 1.1 THz. From the computed permittivity, it is deduced that the leaf specimens increasingly become transparent to the THz waves as they dry out with the passage of days. Moreover, the loss in weight and thickness of leaves were observed due to the natural evaporation of leaf moisture cells and change occurred in the morphology of fresh and water-stressed leaves. It is also illustrated that loss observed in WC on day 1 was in the range of 5\% to 22\%, and increased from 83.12\% to 99.33\% on day 4. Furthermore, we observed an exponential decaying trend in the peaks of the real part of the permittivity from day 1 to 4, which was reminiscent of the trend observed in the weight of all leaves. Thus, results in paper demonstrated that timely detection of water stress in leaves can help to take proactive action in relation to plants health monitoring, and for precision agriculture applications, which is of high importance to improve the overall productivity.
El IMPACTO Y LOS EFECTOS LA ECONOMÍA COLABORATIVA Y DE PLATAFORMAS EN EL EMPLEO DEL SECTOR TURÍSTICO
Authors: RODRÍGUEZ CRESPO Mª JOSÉ
Published: July 2019

La incidencia económica del consumo colaborativo en los mercados turísticos viene acompañada por una transformación del trabajo que lo posiciona como una fuente potencial de empleo en los próximos años. La extensión de este modelo de negocio en el sector turístico afectará sin duda a todas las actividades que se engloban dentro del mismo: hostelería, restauración colectiva, agencias de viajes, actividades de ocio, etc.
Analizaremos en nuestro estudio las claves de este nuevo modelo de negocio y de las implicaciones que habrá de tener en el empleo en el sector de turismo, así como los desafíos a los que los trabajadores deberán afrontar para poder optar para insertarse en un mercado laboral caracterizado por su flexibilidad y por la exigencia de nuevas competencias y perfiles profesionales.
“What is the actual goal of the pathway?”: Examining emergency department clinicians’ perspectives on the implementation of a pediatric concussion pathway using the Theoretical Domains Framework
Authors: Ly Anh , Zemek Roger , Wright Bruce , Zwicker Jennifer , Schneider Kathryn , Mikrogianakis Angelo , Conradi Alf , Johnson David , Clark Brenda , Barlow Karen , Burey Joseph , Kolstad Ashley , Yeates Keith
Published: July 2019

Background

Multiple evidence-based clinical practice guidelines (CPGs) exist to guide the management of concussion in children, but few have been translated into clinical pathways (CP), which operationalize guidelines into accessible and actionable algorithms that can be more readily implemented by health care providers. This study aimed to identify the clinical behaviours, attitudinal factors, and environmental contexts that potentially influence the implementation of a clinical pathway for pediatric concussion.

Methods

Semi-structured interviews were conducted with 42 emergency department clinicians (17 physicians, 25 nurses) at five urban emergency departments in Alberta, Canada. A Theoretical Domains Framework (TDF)-informed interview guide contained open-ended questions intended to gather feedback on the proposed pathway developed for the study, as well as factors that could potentially influence its implementation.

Results

The original 14 domains of the TDF were collapsed into 6 clusters based on significant overlap between domains in the clinical behaviours, thematic areas, and other issues raised by clinicians: 1) knowledge, skills, and practice; 2) professional roles and identity; 3) attitudes, beliefs, and motivations; 4) goals and priorities; 5) local context and resources; and 6) engagement and collaboration. The 6 clusters identified in the interviews each reflect 2-4 predominant topics that can be condensed into six overarching themes regarding clinicians’ views on the implementation of a concussion CP: 1) standardization in the midst of evolving research; 2) clarifying and communicating goals; 3) knowledge dissemination and alignment of information; 4) a team-oriented approach; 5) site engagement; and 6) streamlining clinical processes.

Conclusion

Application of a comprehensive, evidence-based, and theory-driven framework in conjunction with an inductive thematic analysis approach enabled six themes to emerge as to how to best implement a concussion clinical pathway. These overarching themes must be addressed to successfully implement a CP for pediatric concussion.