bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Diffrence of Completeness of Reporting and Documentation of Laboratory Critical Values Pre and Post-Intervention in Bona Ward Dr. Soetomo Hospital Surabaya
Authors: Zubir Zubir , Kahar Hartono , Fuadi M. Robiul , Sulistyani Elly , Yustiawan Tito
Published: January 2020

Completeness of laboratory critical values reporting and documentation in medical records is important for patient safety, hospital accreditation, and legality. Preliminary study in Dr. Soetomo Hospital's ward showed the laboratory critical value report and documentation was 0% complete, 4% incomplete, and 96% undocumented. This was a quasi experimental study with one group pretest and posttest design. Technical guidance of laboratory critical values reporting and documentation in medical records and supervision were given to 26 doctors. The results evaluated were doctor knowledge and attitude towards critical value reporting, completeness of documentation in medical records, and turn around time (TAT). Reporting critical values samples number was 72 before and after the intervention. The critical values samples taken by purposive sampling. The data was analyzed using Mann-Whitney test. There were significant differences in the level of knowledge, doctor's attitudes, and completeness of critical values documentation before and after the intervention. Doctors with good knowledge increased from 3.85% to 92.31%. The attitude to complete critical values documentation improved from 0% to 76%. Completeness of critical values documentation in medical records improved from 100% undocumented to 19.44% undocumented, 11.11% incomplete, and 69.45% complete. There were no significant differences of TAT before and after the intervention, all of TAT were less than 30 minutes and meeting the TAT category. The intervention succeeded in increasing doctor knowledge, attitude, and completeness of the laboratory critical values reporting and documentation in the patient's medical record. Keywords: Laboratory critical value, medical record, turn around time.
C-Reactive Protein Levels of Sepsis Patients: A Comparison of Three Immunoassay Methods
Authors: Rahmadhona Devi , Aryati Aryati , Hardiono Hardiono
Published: January 2020

Quick Sequential Organ Failure Assessment (qSOFA) is a modification of the SOFA score that replaces the Systemic Inflammatory Response Syndrome (SIRS) criteria for sepsis diagnosis. C-reactive protein (CRP) is a marker to help diagnose sepsis. There are not many studies about comparison of CRP level with a variety of instruments and methods, currently. This study aimed to analyze differences in CRP results with particle enhanced turbidimetric immunoassay (PETIA), sandwich immunodetection and reflectometry-immunoassay patients. The study used samples of sepsis patients who were treated in emergency care unit, intensive observation rooms, Intensive Care Unit (ICU) and internal medicine wards of the Dr. Soetomo Hospital Surabaya in May-September 2018. A total of 65 sampels of sepsis patient fulfilled the qSOFA criteria. The CRP examination with the three methods were conducted on all study samples. There were significant differences in CRP levels in the sepsis group using the PETIA and Reflectometry immunoassay methods (p = 0.003), thus both of methods cannot be replace each other. There was no significant difference between CRP levels with PETIA and Sandwich Immunodetection (p=0.172) as well as Reflectometry immunoassay and Sandwich Immunodetection (p=0.251). The selection of instruments and methods for CRP examination is adjusted to laboratory needs and facilities.
Correlation of Vitamin D and Calcium Levels in Children in New Diagnosed Epilepsy and Minimal 6 Months After Therapy
Authors: Suwasanti Niluh , Aryati Aryati , Saharso Darto , Marpaung Ferdy Royland
Published: January 2020

INTRODUCTION. Children with epilepsy should take long-term anti-epileptic drugs. Long-term use of anti-epileptic drugs can reduce vitamin D levels. Low vitamin D will lead to low blood calcium levels. This study aims to analyze the relationship between vitamin D and calcium levels in newly diagnosed epileptic children and â‰¥6 months after therapy. METHOD. These was an analytical observational study with cross sectional research design. The vitamin D examination instrument uses the ELFA method (enzyme linked fluorescent assay) with the Vidas instrument from bioMerieux. Samples were collected during June - August 2018 from Inpatient and Outpatient Clinics. The samples were divided into new diagnosis of epilepsy group and 6 months after therapy group. Each group was measured for vitamin D and serum calcium levels. The relationship between the two parameters were analyzed using T-Test independent. RESULTS. From the 19 new diagnosis of epilepsy, there were 57.9% low vitamin D and 10.5% low calcium levels. From the 20 subjects 6 months after therapy, 70% low vitamin D and 25% low calcium levels. There were a relationship between vitamin D and calcium levels in patients with newly diagnosed and â‰¥6 months after therapy. DISCUSSION. Low vitamin D and low calcium levels were found more in the anti-epileptic therapy group than the new diagnosis group of epilepsy. Low vitamin D levels can be caused by the use of long-term antiepileptic drugs that will affect serum calcium levels. CONCLUSION. This study showed a significant relationship between vitamin D and serum calcium levels in patients with newly diagnosed epilepsy and 6 months after therapy. Vitamin D and calsium serum examination should be done in every patient who gets long term therapy of antiepileptic drugs. KEY WORDS. Vitamin D, calcium, epilepsy, ELFA.
Correlation between Changes of NT-Pro BNP and HS-Troponin I Level with Cardiotoxicity in Locally Advanced Breast Cancer After Three Cycles of Neoadjuvant CAF Chemotherapy
Authors: Indriaty Cicilia , Anniwati Leonita , Putranto J.Nugroho Eko , Suprabawati Desak Gede Agung
Published: January 2020

Chemotherapy with cyclophosphamide, adriamycin, and fluorouracil (CAF) regiment in patients with locally advanced breast cancer have a risk of cardiotoxicity. Cardiotoxicity examination standards using left ventricular ejection fraction (LVEF) by echocardiography are considered insensitive for detection of subclinical ventricular dysfunction. NT-pro BNP and Hs-Troponin I (hs-TnI) as cardiac biomarkers are expected to help detect early cardiotoxicity. This study intended to analyze the correlation between changes of NT-pro BNP and hs-TnI levels with cardiotoxicity in breast cancer after three cycles of chemotherapy.This was a cross-sectional observational study, conducted at the Dr. Soetomo General Hospital Surabaya. The subjects consisted of 23 breast cancer patients who underwent chemotherapy with CAF regiment. NT-proBNP and hs-TnI examination used CLIA methods (Immulite 1000, ADVIA Centaur TnI-Ultra). Cardiotoxicity based on decreased  LVEF to more than 10% of the initial LVEF value using echocardiography. Significant increases in NT pro BNP and hs-TnI levels were obtained before and after treatment (p=0.000, p=0.002). A significant decrease in LVEF was obtained before and after treatment (p=0.000), but only 2 patients (8.7%) showed cardiotoxicity. There was no correlation between changes in NT-pro BNP and hs-TnI levels with changes in LVEF before and after chemotherapy (p=0.666 and r=0.095; p=0.254 and r=-0.28). There was no correlation between changes in NT-pro BNP and hs-TnI levels with cardiotoxicity, which was assessed based on LVEF reduction, in locally advanced breast cancer after three-cycles of chemotherapy with CAF regiment.
Platelet Count and Platelet Index as Prognosis Markers in Adult Septic Patients
Authors: Tiro Steven , Samad Raehana , Bahrun Uleng
Published: January 2020

Sepsis is a major health problem with recent increase of incidence. One of life-threatening complications of sepsis isDisseminated Intravascular Coagulation (DIC). DIC in sepsis can trigger an increase of platelet destruction which can beassessed by platelet count and platelet index. Hence, this research aimed to analyze the correlation of platelet count andplatelet index to the prognosis of adult septic patients. This research was then performed with a retrospective longitudinalstudy design. This research used the medical record data of adult septic patients at the Dr. Wahidin Sudirohusodo GeneralHospital in Makassar. The data of platelet count and platelet index were collected from routine blood of the patients for thefirst time they were diagnosed with sepsis. In total, this research was performed on 100 adult sepstic patients. Fifty of thosepatients had a good prognosis (cured), while the other fifty patients had a poor prognosis (died). Statistical results showedthat the platelet count in the adult sepsis patients with a poor prognosis was significantly lower than those in patients with agood prognosis with median/minimum-maximum of 157,000/12,000-626,000 and 329,000/96,000-801,000, respectively(p=0.00). It was also known that there was no significant difference of MPV values between patients with poor prognosis andpatients with good prognosis with Mean±SD of 9.54±1.44 and 10.08±2.09, respectively (p=0.138). Unlike MPV values, PDWvalues in patients with poor prognosis were significantly higher than those in patients with good prognosis with Mean±SDof 16.7±6.26 and 11.25±2.13, respectively (p=0.00). Thus, it can be concluded that there was an inverse correlation betweenplatelet count and PDW value (r = -0.58). PDW value, as a result, could be used as a prognosis marker for adult septicpatients. However, it was recommended to perform further research as a prospective study by removing the possibility ofbias.
Evaluation of Pleura Efusion Determination by Light's and Heffner's Cciteria
Authors: Ali Nor Jannah , Kartini Ani , Effendi Darmawaty
Published: January 2020

EVALUATION OF  PLEURA EFUSION DETERMINATION BY LIGHT'S DAN HEFFNER'S CRITERIANordjannah1, Ani Kartini2, Darmawaty ER 31 Medical Doctor Specialist Education Programe of Clinical Pathology, Faculty of Medicine Hasanuddin University/dr.Wahidin Sudirohusodo Hospital, Makassar2  Department of Clinical Pathology Faculty of Medicine, Hasanuddin University/ Labuang Baji Hospital  Makassar3 Department of Clinical Pathology Faculty of Medicine, Hasanuddin University/ Hospital Islam Faisal Hospital  Makassar  ABSTRACT Background : Pleural effusion is a condition of abnormal pleural fluid accumulation in the pleural cavity due to excessive transudation or exudation. Light's criteria is used as the standard method to distinguish between exudates and transudates. Some recent studies reported misclassifications so several alternative criteria are developed, one of which is Heffner's criteria. The purpose of this study was to determine the sensitivity and specificity of Heffner's criteria in determining the type of pleural effusion.Methods : An observational study with cross sectional method using a pleural effusion fluid sample of patients examined at the Clinical Pathology Laboratory Instalation at Wahidin Sudirohusodo Hospital on July 2018. Total protein, LDH and cholesterol levels were examined in all samples that met the inclusion and exclusion criteria.Results : There were 45 samples of pleural effusion, 30 of which classified as transudate and 15 samples as exudates. Based on clinical diagnosis, the Light's criteria obtained 3 misclassifications and Heffner's criteria obtained 2 misclassifications. Based on the data above, the statistical data showed that Light's criteria has sensitivity of 96,7 % and specificity of 86,7 %. Heffner's criteria has sensitivity of 100 % and specificity of 86,7 %.  Conclusion : Heffner's criteria offers better sensitivity and specificity than Light's criteria. Heffner's criteria can be used as an alternative in determining the type of pleural effusion Keywords: Heffner's criteria, Light's criteria, transudate, exudate, pleural effusion
Differences of Vitamin D Levels in Controlled and Uncontrolled Type 2 Diabetes Mellitus Patients
Authors: Azlin Adhisti , Ganie Ratna Akbari , Syafril Santi
Published: January 2020

Vitamin D as an immunomodulator, plays an important role in controlling glycemic levels and decreasing diabetes complications. HbA1c is a marker of glycemic control which is known to have association with vitamin D. This study aims to see the differences in vitamin D serum levels and glycemic index in patients with type 2 DM.The design of this study is cross-sectional study and it was performed in RSUP HAM in December 2017 until March 2018. DM type 2 patients were classified based on HbA1c <7% controlled and â‰¥ 7% uncontrolled. Vitamin D serum levels were examined using the Enzyme-Linked Fluourescent Assay (ELFA) method., differences in vitamin D levels among controlled and uncontrolled type 2 diabetes mellitus were assessed by using independent t-test, and the differences of HbA1c level were assessed using Mann-Whitney-U test.45 patients with type 2 DM were divided into controlled (HbA1c <7%) and uncontrolled patients (HbA1c â‰¥ 7%). There was no difference in vitamin D serum levels between controlled and uncontrolled DM Type 2 patients (p = 0,310).
Comparison of Lipid Fractions of Icteric Sample by Using Three Devices
Authors: Khair Ummul , Nurulita Asvin , Muhadi Darwati
Published: January 2020

COMPARISON OF LIPID FRACTIONS OF ICTERIC SAMPLE BY USING THREE DEVICES Ummul Khair1, Asvin Nurulita2,3, Darwati Muhadi2,31                      Specialist Doctoral Education Program of Clinical Pathology Science, Faculty of Medicine, Hasanuddin University/RSUP Dr. Wahidin Sudirohusodo, Makassar 2                      Department of Clinical Pathology Science, Faculty of Medicine, Hasanuddin University/RSUP Dr. Wahidin Sudirohusodo, Makassar3RSUP Dr. Wahidin Sudirohusodo, Makassar                                                                                ABSTRACTIntroductionLipid fraction assessment in laboratory includes cholesterol, HDL, LDL, Triglycerides. The icteric sample is characterized by elevated levels of bilirubin and darkness yellow sample color. This research was to determine the comparison of lipid fraction of icteric sample by using three devices.MethodCross-sectional study at Clinical Pathology Laboratory of Dr. Wahidin Sudirohusodo of Makassar. Comparison of lipid fraction of icteric samples against 3 (three) devices (Pentra, Biomajesty, Conelab) in period April - June 2018. Statistical analysis using SPSS program.Result and Discussions Total sample of 50 indicated that cholesterol level by Biomajesty was lower than Pentra400 (p < 0.001), while the cholesterol level by Conelab was significantly lower than Pentra400 (p > 0.001), but not significantly different with Biomajesty (p < 0.05). HDL level by Biomajesty did not differ significantly with Pentra400 (p > 0.05). HDL level by Conelab were significantly lower than Pentra400 (p < 0.001) and Biomajesty (p < 0.01). HDL level by Biomajesty was smallest than Pentra and Conelab. LDL level by Biomajesty did not differ significantly with Pentra400 (p > 0.05) while LDL level by Conelab was significantly lower than Pentra400 (p < 0.001) and Biomajesty (p < 0.001). It can be seen that the range of TG by Biomajesty is smallest (more accurate) than Pentra400 and Conelab. TG level by Biomajesty was significantly lower than Pentra400 (p < 0.01) while TG level by Conelab was not significantly different than Pentra400 (p > 0.05), but it was significantly higher than Biomajesty (p < 0.001).Conclusion and RecommendationThe research shows that Biomajesty is an accurate device for the measurements of HDL, LDL, and TG of icteric samples, whereas Conelab is an accurate device for cholesterol measurement of icteric samples.KeywordsLipid fraction, icteric sample, Pentra, Biomajesty, Conelab
Quality Improvement Efforts in Pre-Analytical Phase
Authors: Sianipar Osman
Published: January 2020

In a clinical laboratory services pre-analytical phase has plays an important role in term of quality and patient safety. Pre-analytical phase is a phase before analyzing sample in laboratory which  includes  patient preparation, sampling, labeling, sample transportation, sample storage,  and preservation of samples that might influence the laboratory results. In this phase it involves interaction between patient, doctor, laboratory personels, and other staff outside the laboratory. Therefore, it could be assumed that in this phase many sample are collected, many laboratory tests are requested, many individuals are involved and therefore laboratory errors might be occured. Laboratory errors can occur either in pre-analytical, analytical, or post analytical phases but the most frequently errors occur in pre-analytical phase. In this article, quality improvement efforts in pre-analytical phase will be discussed in order to minimize pre-analytical error.
Gestational Trophoblastic Neoplasia with Hyperthyroidism
Authors: Rahmadhona Devi , Tambunan Betty Agustina
Published: January 2020

Gestational Trophoblastic Neoplasia (GTN) is a malignant lesion arising from placental villous and extra-villoustrophoblastand occurs in 1:40,000 pregnancies. Invasive mole and choriocarcinoma are the vast majority of GTN whichproduce substantial amounts of Human Chorionic Gonadotropin (hCG). Hyperthyroidism in GTN is due to the stimulation ofthe thyroid gland by hCG which has a similar structure with Thyroid-Stimulating Hormone (TSH). A 28-year-old female,suspected with choriocarcinoma and anemia, had a history of recurrent vaginal bleeding for eight months, accompaniedwith loss of appetite, weight loss, palpitation, and tremor. Physical examination such as pulse rate of 114x/minutes, the0 respiration rate of 26x/minutes, temperature 38 C, conjunctival anemia, and dyspnea were reported. In addition, laboratoryfindings such as anemia, leukocytosis, hypoalbuminemia, hypokalemia, increase of LDH, increase of hCG >1,500,000mIU/mL, T4 levels of 14.1 ug/dL (4.40-10.90 ug/dL), FT4 levels of 1.95 ng/dL (0.89-1.76 ng/dL), and decrease of TSH were alsoreported. Abdominal CT Scan suggested uterine mass suspected as malignancy infiltrating to the rectum with metastaticfeatures in the liver, base of left lung, spleen and left kidney. Increased CA-125, and metastatic features of lung rightparacardial and left suprahilar from Chest X-ray were found. Diagnostic criteria for gestational trophoblastic neoplasia are asfollows: increased hCG 4 x tests; increased hCG three weekly tests; histology diagnosis of choriocarcinoma; increased hCG> 20,000 more than four weeks post evacuation and the presence of metastasis. Hyperthyroidism in GTN is potentiallylife-threatening because of heart failure and thyroid storm. Hyperthyroidism increases morbidity and mortality in GTNpatient; therefore, periodic thyroid tests is essential to prevent further complication of hyperthyroidism.
Description of Fecal Culture Results in Diarrhea Patients Due To Antibiotic Use
Authors: Tresna Suci , Rejeki I.G.A.A Putri Sri , Wardhani Puspa
Published: January 2020

Diarrhea infection is common in developing countries and causes death of around 3 million people every year. Diarrheais also the second leading cause of death in infants. Riskesdas in 2013 showed 30,775 cases of diarrhea. Causes were such asbacterial infections Salmonella, Shigella, Vibrio, Entamoeba, and Yersinia. Other influences can occur due to viral andfungal infections. Diarrhea is a nosocomial infection that is common in hospitalized patients due to the long-term use ofantibiotics caused by Clostridium difficile. This study was a follow-up study of diarrhea patients who received antibiotictherapy for more than two days with the results of C.difficile negative toxin, then continued with fecal culture examination.This study aimed to look at the description causes of diarrhea other than C.difficile in patients who received long-termantibiotic therapy. This research is an observational study. Samples were taken from 30 diarrhea patients with 2 x 24 hours ofantibiotic use who were hospitalized in the ICU, Dr. Soetomo Hospital Surabaya from August 2017 to May 2018. Sampleswith negative C.difficiletoxin results were then followed by fecal culture examination using conventional methods. Theresults of culture examination from 30 samples showed three samples with positive culture results extended-spectrumÎ² lactamase producing E.coli, two samples positive culture just E.coli, and 25 other samples showed negative culture results.The results of the fecal culture examination showed a description of causes of diarrhea in patients who received antibiotictherapy was pathogenic E.coli (ESBL). The possibility of other causes that cannot be detected from the culture such as viraland fungal infections, still requires further research.
Seropositivity of Anti-Rubella Antibodies as A Marker for Rubella Infection in Infants at High Risk of Congenital Deafness
Authors: Purnami Nyilo , Etika Risa , Martono Martono , Wardhani Puspa
Published: January 2020

Hearing loss in newborns or congenital deafness can be caused by the development of several parts of the auditorysystem. Congenital deafness is often associated with infections, such as Toxoplasmosis, Rubella, Cytomegalovirus (CMV),and Herpes (TORCH). Deafness is very difficult to be early detected. Therefore, simple but fast methods are needed. Earlydetection is based on the Newborn Hearing Screening (NHS) program. Otoacoustic Emission (OAE) and AutomatedAuditory Brainstem Response (AABR) checks are raw materials for early detection. Congenital deafness often occurs withpregnancy infections with viruses such as Rubella. Rubella infection during pregnancy, especially during the first trimester,often causes Congenital Rubella Syndrome (CRS). Rubella infection often occurs with other causes, such as Toxoplasma,CMV, and Herpes. A Serological test can be used as one of the diagnostics of this infection. This study used single RubellaIgG and IgM antibodies and double antibodies test as a marker for the infection. The authors wanted to correlate theserological examination of this infection with the auditory function. Rubella infection was detected with single serologicalanti-Rubella IgG and IgM and double multiple Rubella and TORCH serological tests. Also, the auditory function wasassessed using the OAE and AABR test in this research. The result showed 35 (77.7%) patients with positive Rubellaserological tests among 45 NICU patients at Dr. Soetomo Hospital. There were number of patients was 12 (34.2%) patientswith a single positive serological test and 23 (65.7%) patients with positive multiple TORCH serological tests. The number ofpatients with Rubella negative infection was 10 (22.2%). There were 11 (31.4%) patients of positive Rubella infections withpositive hearing loss and 24 (68.6%) patients with negative hearing loss. From the results of the study, 35 patients were athigh risk of disturbance and the statistical analysis showed that there were no significant serological differences in Rubellapositive with hearing loss (p=0.087). Hearing loss in NICU infants has a high risk of factors causing Rubella infection andother related causes. In most Rubella positive serological tests IgG was found, which can be due to maternal factors.Serology tests need to be repeated for confirmation under the surveillance program. How to follow-up the patients anddefine the next laboratory test after six months remain a great challenge. The efforts need to be strengthened in surveillanceprograms.
Infection of Cytomegalovirus in Cholestasis Infant with Biliary Atresia
Authors: Situmorang Lasmauli , Setyoboedi Bagus , Arief Sjamsul , Mastutik Gondo
Published: January 2020

Biliary Atresia (BA) is extrahepatic cholestasis that results in death within the first two years if the diagnosis andintervention are delayed. The etiology and pathogenesis of BA are still undetermined. Viral infections, includingCytomegalovirus (CMV), are presumed to be one of the causes. Cytomegalovirus infection is more common in intrahepaticthan extrahepatic cholestasis such as BA. There are limited data about Cytomegalovirus infection in cholestatic infants withBA. This study compared the incidence of CMV infection in cholestatic infants with biliary atresia and non-biliary atresia.A cross-sectional study was performed in December 2017 - August 2018 in cholestatic infants aged 1-6 months. Liverbiopsy, histopathological examination followed by PCR CMV examination were performed on cholestatic infants. Theresults of the PCR examination were compared between BA and non-BA infants. Statistical analysis of Chi-Square, t-testindependent and Mann-Whitney U resulting in p<0.05 were stated as significant. Thirty-seven children were obtainedduring the study period, consisting of sixteen children with BA and twenty-one children with non-BA. Biliary atresia waspredominantly found in female than male children, despite no differences were found between the groups (p=0.163). Therewere differences in body weight (p=0.002) age (p=0.009), birth weight (p=0.02) and gestational age (p=0.03) betweenchildren with BA and non-BA. There was no significant difference in the incidence of CMV infection in cholestatic infants withBA and non-BA (p=0.338). Cytomegalovirus infection in cholestatic infants with BA was less than non-BA cholestatic infants.
Human Sperm Cells After Purification Using SCLB Can Be Stored at 4o, -20o, or -80oC Before Small RNA Isolation
Authors: Hamidah Berliana , Sa'adi Ashon , Yudiwati Rina
Published: January 2020

There have been many studies about pre-analysis for sperm RNA examination which compared sperm purificationmethods, RNA isolation methods, sequencing methods, and semen storage before analysis. However, there is a lack ofstudies that determine the ideal storage temperature after sperm cell purification before RNA analysis, especially small RNAanalysis. The aim of this study was to determine the preferred storage temperature for human sperm cells after spermpurification using Somatic Cell Lysis Buffer (SCLB) before sperm small ribonucleic acid (RNA) isolation and analysis. Thisstudy was a true laboratory experiment using the post-test only control group design. The samples were 13 fresh humansemen that has been purified using SCLB. The sperm cells were then diluted and divided into four aliquots with differenttreatments. The first aliquot that served as a control group was immediately purified while the other three aliquots were0 0 0 stored for seven days at different temperatures as follows: 4 C, -20 , and -80 C. After the small RNA isolation, RNA levelbetween each group was compared. Micro volume spectrophotometer measured RNA level. The median of small RNA6 yields of the control group was 49.8 (5.33-522.46) ng/10 sperm cells. There was no significant difference in median of smallRNA yields of the control group and that of other groups. The median of the other groups with storage temperature0 0 0 6 of 4 C, -20 , and -80 C was 41.09 (7.03-1448.31), 65.95 (7.99-301.16), and 76.42 (10.45-434.25) ng/10 sperm cells,respectively (p-value= 0.314; Î±=5%). This condition suggested that after purification using SCLB, human sperm cells can be0 0 0 stored at temperatures of 4 C, -20 , or -80 C for seven days, depending on each laboratory facility.
Analysis of Hematologic Parameters and Serum Bilirubin Levels in Complicated and Uncomplicated Acute Appendicitis Patients
Authors: Rahman Rini , Kartini Ani , Widaningsih Yuyun , Abdullah Agus Alim
Published: January 2020

Acute appendicitis is inflammation of the vermiformis appendix due to lumen obstruction followed by bacterial infection. Acute appendicitis is classified into two types of disease, namely complicated and uncomplicated. Acute inflammation of the appendix requires immediate surgical action to prevent complications; therefore, a further laboratory test is required. This study was retrospective research which analyzed several hematologic parameters (WBC, Neutrophils, NLR, RDW, PLTMPV, PDW) and serum bilirubin levels. Data were statistically analyzed using Independent-t and Mann-Whitney test. Univariate logistic regression test was used to evaluate the correlation of hematologic parameters and significant serum bilirubin levels with the diagnosis of complicated and uncomplicated appendicitis. The cut-off value and diagnosis value were measured using Receiver Operating Characteristic (ROC) curve analysis. This study involved 173 subjects categorized into 67 complicated and 106 uncomplicated acute appendicitis patients. Whole blood count and neutrophil counts were significantly higher in complicated acute appendicitis (p <0.05). Similarly, NLR and PLT were significantly higher in complicated acute appendicitis (p <0.001), p > 0.05 was obtained in RDW-CV, MPV and PDW values. The higher serum bilirubin levels were reported in patients with complicated acute appendicitis compared to uncomplicated acute appendicitis (p <0.001). Logistic regression test results showed significant PLT parameters with p <0.001, while there was no significance of hematologic parameters such as WBC, neutrophil, NLR, RDW-CV, MPV, PDW and bilirubin levels. Area under curve results on the ROC curve showed 74.4% PLT with sensitivity and specificity of 97.17% and 40.29%, respectively. From the analysis of hematologic parameters and measurement of serum bilirubin levels, only the PLT parameter can be used as one of the parameters for the diagnosis of complicated appendicitis with high sensitivity but low specificity. It was recommended to perform prospective studies with more subjects.
Penggunaan Pot Berbahan Dasar Organik untuk PembibitanGmelina arborea Roxb. di Persemaian
Authors: Budi Sri Wilarso , Sukendro Andi , Karlinasari Lina
Published: January 2020

The objectve of this research was to obtain the best materials composition and adhesive of organic pot for forest trees seedling production. Organic pot strength was evaluated by testing the strength of rupture elasticity and elasticity stiffness of each composition. The bioassay testing used Completely Randomized Design with factorial pattern, consisting of two factors, (1) basic raw materials of the pot (used newspaper, litter and compost) and (2) the type of adhesive (control, tanin and starch). The results showed that the adhesive starch gave higher strength, whereas adhesive tannin gave higher stiffness as compared to control. Results of bioassay showed that the mixture (50:50 v/v) of basic materials of used newspaper and compost (KKK) which were glued with tannin, produced the best results for height and diameter increament with the value of 35.85 cm, 0.31 cm respectively and biomass value of 0.99 g after 12 weeks of planting. The highest level of damage in organic pot with basic raw materials KKK without adhesive was 47.6%, whereas lowest level of damage in organic pot with basic raw material used newspaper (KK) with tannin addhesive was 2.0% after 12 weeks in the nursery.Keywords: adhesive, Gmelina arborea,organic pot, organic matter, nursery,
Towards the science of managing for innovation: conclusion & future research directions
Authors: Mention Anne-Laure , Pinto Ferreira João José , Torkkeli Marko
Published: January 2020

We initiated this series with a view to catalyse and extend the focus on conceptualisation and application of behavioural science methods for managing innovation, albeit from a whole human perspective. We started with the notion that how to increase individual (human) creativity, collaboration productivity and innovativeness in innovation projects is a common concern for most firms. After discussions on the brain-mind-behaviour triad in the beginning, the interim editorial highlighted behavioural experiments as one plausible method to further the science of managing for innovation. In this final piece on the series, we conclude with a caveat on using experimental methods in examining the human side of innovation (Salampasis and Mention 2017) and discuss avenues for future research in innovation management, which increasingly reflects a collaborative affair (Bogers et al., 2017; Heil and Bornemann 2018). (...)
The Importance of Taking a Process Perspective on the Use and Application of an Innovation Management Self-Assessment Audit
Authors: Blackbright Helena
Published: January 2020

Prior research on innovation management self-assessment audits (IMSA) has a strong focuson the assessment situation, primarily on what to assess. However, several additional tasks are necessary10 to make purposeful use of an IMSA. This study analyzes the undertaking of an IMSA from a processperspective to better understand IMSA’s utilization by looking at how people participate in the processand how the process is integrated in an organizational context. This study adopted an interactive researchapproach and collected data over a period of 27 months in 45 interviews, six workshops, and 10 meetingswith 42 different participants from three companies. Results show a fragmented participation, and that15 the process was only partly integrated into the organizational context, making it arbitrarily dependenton individual actors. This demonstrates the need to understand challenges related to IMSA use to enablea process that is integrated in the structures intended to be improved.
IMMOBILISASI SUSPENSI AKTIF PADA PELLET AMMONIA OXIDIZERS UNTUK PENGOLAHAN LIMBAH URIN KAMBING MENJADI PUPUK N
Authors: Tiara Atita Arli , Budiarsa Suyasa I Wayan , Kunti Sri Panca Dewi I Gusti Ayu
Published: January 2020

Livestock waste that is thrown away without being processed will cause environmental pollution, therefore an effort is needed to process the livestock waste is to be processed into organic fertilizer. The part of livestock waste that can be used as organic fertilizer is urine, in this study goat urine is used. This study aims to find the best nutrients for seeding active suspension, look for the optimal dosage and time for processing goat urine into N fertilizer. The method used in this study is to immobilized the active suspension into the ammonia oxidizers pellets for later used in the goat urine treatment process with an aeration system, so that a nitrification reaction occurs which results is decrease ammonia and nitrite levels and increase nitrate levels.  The results obtained in this study are the nutrients that are best used for seeding active suspension are media II that is 5 grams NPK fertilizer; 2,5 grams NH4Cl; and 5 grams glucose with MLVSS values ??of 9000 mg/L at 18 hours. The processing of goat urine obtained optimal results at pellet dosage of 20% (w/v) with optimal time at 18th hour. Ammonia level obtained was 5.6811 mg/L, nitrite levels of 2.3992 mg/L, and nitrate levels of 10.6618 mg/L. 

Keywords: Immobilization; active suspension; MLVSS; pellets; ammonia oxidizers; nitrification
PENGELOLAAN SAMPAH BERBASIS MASYARAKAT DI DESA PAKRAMAN PADANGTEGAL KECAMATAN UBUD KABUPATEN GIANYAR
Authors: Juniartha I Putu , Antara Made , Sudarma I Made
Published: January 2020

The results of this study indicate: (1) Characteristics of waste in Pakraman Padangtegal Village consisted of 83.88% organic waste, 7.24% plastic waste, 4.42% paper waste, 2.22% bottle waste, glass waste at 1.28% and metal waste at 0.96%; (2) public perception in waste management in Pakraman Village, Padangtegal that most of the people in Pakraman Village, Padangtegal, already know about the definition of waste and the danger of waste if it is not managed properly. Besides that the community also knows the difference between organic and inorganic waste so that the process of sorting waste in the place provided can run well, and the community's perception of waste management services has gone well with the transportation of waste twice a day; (3) the participation of the Pakraman Padangtegal Village community in waste management has played a role in various stages of waste management, starting from the sorting, garbage collection and garbage disposal, which complies with waste regulations and maintains the quality of the environment in Padangtegal Pakraman Village. The participation of the tourism industry in the process of waste management in Pakraman Village, Padangtegal, can be seen as being involved in the process of sorting waste and paying monthly fees and waste fees. The community participation in the waste management process is to help the government to socialize the waste management process by carrying out waste collection activities every week and provide a place for the waste management process. Suggestions in this study are that waste managers will immediately add facilities and infrastructure for waste transportation and accelerate the expansion of waste management in the village of Pakraman Padangtegal.

 

Keywords: Waste Management System, Pakraman Village
PEMETAAN HABITAT PERAIRAN DANGKAL DI KAWASAN PADAT WISATA TANJUNG BENOA BALI MENGGUNAKAN DATA REMOTE SENSING
Authors: Karang I Wayan Gede Astawa , Nagendra I Wayan Matsya Deva , Astaman I Dewa Made Khrisna Putra , Hendrawan I Gede
Published: January 2020

Tourism is a sector that is prioritized in various countries. Most of the tourist objects are distributed along the coast that intersects directly with those that result in the degradation of the ecosystem inside. The southern region of Bali is one of the regions that has experienced rapid development of tourism activities. The expansion of the tourism area in Tanjung Benoa occurs in coastal areas and directly contacts underwater ecosystems such as seagrass beds and coral reefs, which it have an impact on changes in the area of the ecosystem. Information about the form of distribution of underwater objects can be the first step in making ecological-based tourism policy. Satellite imagery can be used to detect shallow-water habitats. The purpose of this study was to determine the effectiveness of sentinel-2 A images to map shallow water habitat in densely packed tourist areas Tanjung Benoa. The results showed that there were three types of land cover in Tanjung Benoa area, such as seagrass, coral and sand, the accuracy results showed landsat 8 images had higher accuracy than Sentinel-2 A images with total accuracy of 74.83% and kappa accuracy of 46.59%. There are 8 types of seagrasses species in the coastal area of Tanjung Benoa, namely Cymodocea rotundata, Enhalus acoroides, Halodule pinifolia, Halodule uninervis, Halophila ovalis, Thalassia hemprichi Syringodium isoetifolium dan Thalassodendron Ciliatum.

Keywords: Remote Sensing; Shallow Water Habitat; Tanjung Benoa; Sentinel-2 A; Landsat 8
Food Shopping Behavior: A Long Way to Prevent Food Waste
Authors: Krisjanti Mahestu N , Quita Agnes Gracia
Published: January 2020

Food sustainability is becoming big concern these last couple years, due to the food scarcity issues in many countries.  However in contrary previous studies reported the food waste behavior is getting bigger at this moment because of over food preparation, food stocking, undesired food, and food packaging. Over all, most of these issues come from the food shopping behavior. People tend to buy more food products than what they need. Therefore, the determinant of food shopping behavior is urgently found in order to find the solution to drive people to have planned food buying behavior. This research elaborates how motivation to prevent food waste would affect food shopping behavior. The data collection through survey has been done in the young adult community. The finding indicates that having motivation to prevent food waste will contribute to well-planned food shopping behavior. Furthermore, the research also indicates that female shows higher motivation in preventing food waste as also reported in some previous studies that report similar result.
Tocilizumab treatment in juvenile idiopathic arthritis patients: A single center experience
Authors: Demir Selcan , Sönmez Hafize Emine , Arslanoğlu-Aydın Elif , Özen Seza , Bilginer Yelda
Published: January 2020

Tocilizumab is a monoclonal antibody against interleukin-6 that has recently emerged as an alternative treatment modality for juvenile idiopathic arthritis (JIA). In the present study, we aimed to discuss the clinical and laboratory findings and treatment response of JIA cases to tocilizumab therapy. This retrospective study included 20 JIA patients aged between 0-18 years who were followed up from 2014 to 2016 and received tocilizumab treatment in our clinic. Treatment response could be not evaluated in two patients since they developed anaphylactic reactions due to tocilizumab. Of the remaining 18 patients, seven of them (38.9%) had polyarticular JIA, and eleven (61.1%) had systemic JIA. Platelet counts, erythrocyte sedimentation rate and C-Reactive protein (CRP) levels, active joint counts, and Juvenile Arthritis Disease Activity Score 71 (JADAS71) were significantly decreased at the third month in both polyarticular and systemic JIA, while there were not any significant differences between the third and sixth months. All of the patients with polyarticular JIA had low disease activity at six months. Eight patients with systemic JIA had an inactive disease at six months, whereas the remaining three patients had high levels of CRP without presence of any clinical symptoms. Steroid treatment was terminated at the sixth month in all patients except for three patients who continued to receive 0.05-0.25 mg/kg steroid treatment. Two patients developed thrombocytopenia, one patient developed macrophage activation syndrome, and one patient had elevated transaminases due to tocilizumab treatment. Previous studies have shown that tocilizumab treatment is well-tolerated, effective, and safe for use in JIA patients. In the present study, we also demonstrated the efficacy of tocilizumab treatment in JIA patients from our clinic.
Evaluation of growth in children and adolescents after renal transplantation
Authors: Büyükkaragöz Bahar , Bakkaloğlu Sevcan Azime , Tuncel Ayşe Fitnat , Kadıoğlu-Yılmaz Banu , Karcaaltıncaba Deniz , Paşaoğlu Hatice
Published: January 2020

Despite the advances in the last decades, it is well-known that optimal growth is usually not achieved in children with chronic kidney disease (CKD) even after successful renal transplantation (RTx). In this study, our aim was to evaluate growth patterns and factors affecting growth in pediatric and adolescent renal transplant recipients (RTR). Thirty-seven prevalent RTR with mean age of 17.0±2.9 years and mean post-RTx duration of 4.2±2.0 years were evaluated. Growth parameters, height velocities and factors affecting growth at the time of RTx (baseline) and in the post-RTx follow-up were also retrospectively assessed. Cumulative corticosteroid (CS) doses were calculated. Mean height and weight standard deviation score (SDS) values were negative (-1.4±1.1 and -1.2±1.5, respectively), whereas height SDS was positive in 16% of the patients. Mean weight, height, and BMI (body mass index) SDS of the RTR were significantly higher than the values at transplantation (p < 0.001 for weight and height SDS; p < 0.05 for BMI SDS). Height SDS was < -2.0 in 19% of the patients while 60% at the baseline. Main factors associated with post-RTx height SDS were pre-RTx height SDS (B: 0.448, p < 0.01) and CKD duration (B: -0.01, p < 0.05). Although it was much better than the pre-RTx period, the present study reveals that post- RTx growth was less than anticipated. As well as minimizing post-RTx CS doses and preserving graft function in the post-RTx follow-up, performing early transplantation and all efforts for minimizing pre-RTx growth deficit are crucial for an optimal post-RTx growth.
A rare chromosomal disorder in a newborn: Trisomy 3q
Authors: Kahvecioğlu Dilek , Tatar-Aksoy Hatice , Yıldız Eren , Bakır Abdullatif , Alioğlu Bülent
Published: January 2020

Trisomy 3q is a rare chromosomal disorder that leads to multiple congenital abnormalities. We hereby present a patient with chromosomal karyotype 46, XY, dup (3)(q23-29), which can be classified as pure 3q duplication and has thin sclera and iris dysgenesis, anterior and posterior segment dysgenesis besides the previously identified specific facial features. To the best of our knowledge only 12 cases have been reported with pure duplication in the literature. Our case is the 13th one reported and has noval findings concerning eye involvement. The ocular manifestations of the 3q duplication syndrome provide additional evidence of the involvement of genes which are responsible for eye development in this chromosomal region.
The structure of cardiac surgery and interventions in heart failure management in the Kyrgyz Republic: A retrospective analysis
Authors: Kudaiberdiev Taalaibek , Ashirov Kanat , Akhmedova Irina , Imanov Bakytbek , Zhooshev Akylbek , Abibillaev Damirbek
Published: January 2020

In this study, we retrospectively analyzed the cardiac surgical and interventional care of patients with chronic heart failure hospitalized in Scientific-Research Institute of Heart Surgery and Organs Transplantation (SRIHSOT) and Osh Interregional United Clinical Hospital (OIUCH).
Sosialisasi Dan Pelatihan Alih Media Kaba
Authors: Almos Rona , Hidayat Herry Nur , Wasana Wasana , Meigalia Meigalia
Published: January 2020

Dalam upaya mengenalkan dan melestarikan karya seni budaya tradisi kaba, adanya sebuah transformasi tersebut. transfromasi itu adalah perubahan menjadi bentuk komik sehingga diharapkan akan lebih mudah diterima oleh khalayak penikmat terutama remaja dan anak-anak. Kegiatan ini adalah wujud kelanjutan hasil penelitian terhadap kemungkinan transformasi cerita kaba menjadi cerita anak dan komik. Pelaksanaan kegiatan berisi diskusi dan pelatihan   alih media kaba menjadi carita anakdan komik. Oleh karenanya, kegiatan ini dilaksanakan dalam dua bagian, ceramah dan diskusi serta pelatihan singkat. Berdasarkan pengamatan terhadap kegiatan ini, diperoleh simpulan kurangnya materi dan bahan ajar muatan lokal yang lebih menarik dan diterima oleh siswa didik untuk peningkatan pengetahuan mereka terhadap muatan lokal keminangkabauan, terbatasnya pengembangan muatan keminangkabauan, penguasaan materi keminangkabauan yang tinggi tidak diimbangi dengan kreativitas pengolahannya menjadi bahan ajar yang lebih baik.
Christians and Jews: historical and theological perspectives of their relationship
Authors: Perzyński Andrzej Piotr
Published: January 2020

The article analyses the subject of Christian-Jewish relations in historical and theological terms. In the historical part the following periods are briefly discussed: New Testament, patristic, medieval, modern and contemporary. In the theological part, the common elements of Judaism and Christianity were first presented: - Jews and Christians identify their faith and action through the interrelations between justice and love; they base their beliefs on the common “scripture” (the “Old Testament”); they understand each other as the people of God; they profess the one God, the Creator and the Redeemer; they express their faith in worship, in which there are many similarities; Jews and Christians also live in the expectation for the common history of God with his people, whose fulfillment they expect. Distinctive elements (The divergence of the ways) are: the belief in Jesus, the Christ; the interpretation of the Scriptures; a different understanding of what God’s people are; different developed piety. In conclusion, it was said that the rediscovery of a positive relationship with Judaism facilitates a positive formation of Christian identity and memory.