bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the effectiveness of using remote monitoring of blood pressure in the dispensary observation of patients with arterial hypertension
Authors:   Tyumen State Medical University, Reshetnikova I. S. , Brynza N. S. ,   Tyumen State Medical University, Nemkov A. G. ,   Department of Health of the Tyumen Region,   Tyumen State Medical University, Kurmangulov A. A. ,   Tyumen State Medical University, Kononykhin A. A. ,   Tyumen State Medical University
Published: June 2023

Arterial hypertension (AH) is by far the most important risk factor for cardiovascular disease. An effective method of dealing with high blood pressure (BP) is dispensary observation. Of particular relevance is the search for new tools to improve the dispensary observation of patients with hypertension, one of which may be remote monitoring of blood pressure, as an option for providing medical care using telemedicine technologies. Purpose of study – Analysis of the effectiveness of using remote monitoring of blood pressure in the dispensary observation of patients with hypertension. Methods. A non-randomised, open-label, generalized, single-centre, retrospective, longitudinal, parallel, applied study included 78 patients who completed a remote blood pressure monitoring program who were subsequently divided into 2 groups depending on the degree of achievement of target values of blood pressure (<135/85 mm Hg). Results. During the observation period, all patients (n=78) experienced a decrease in SBP by 8.2 mmHg, DBP at 3.8 mmHg. Group 1 consisted of 35 patients who reached target levels of blood pressure, group 2 included 43 patients who did not reach target levels of blood pressure. Initially, the groups did not differ in sex and age, while in the second group, the initial values of SBP and DBP were higher. The study found that the degree of achievement of target levels of blood pressure is influenced by the following factors: the level of SBP and DBP at the beginning of observation, the proportion of extraordinary measurements with blood pressure levels above 135/85 mmHg during the observation period, the proportion of missed blood pressure measurements during the observation period, as well as the duration of remote monitoring. Conclusions. Remote monitoring of blood pressure is an effective tool for improving the dispensary observation of patients with arterial hypertension and can improve the availability and quality of medical care.
Aspects of the quality of the life of persons of working age with chronic noncommunicable diseases of the respiratory organs
Authors:   FSBEI HE “Privolzhsky Research Medical University” of Ministry of Health of the Russian Federation, Sheyykhova S. S. , Pozdeeva T. V. ,   FSBEI HE “Privolzhsky Research Medical University” of Ministry of Health of the Russian Federation, Kotova N. V. ,   FSBEI HE “Privolzhsky Research Medical University” of Ministry of Health of the Russian Federation
Published: June 2023

Chronic noncommunicable diseases (NCD) are widespread and affect people of different age groups in all countries. The fight against this group of diseases is one of the priorities of the modern health care. Non-infectious diseases of the respiratory system as well as other diseases, affect social, physical and mental components of well-being. The qualitative assessment of their influence helps to assess the study of the quality of life. P u r p o s e : to assess the quality of life of the working-age population of the Nizhny Novgorod region and to develop measures to reduce the risk factors for chronic non-infectious diseases of the respiratory system in these cohorts. M a t e r i a l s a n d m e t h o d s . A one-stage comparative study was carried out using the method of standardized interviewing using the SF‑36 questionnaire. The quality of life of people of various age-gender groups with chronic non-infectious diseases of the respiratory system was assessed. All respondents were stratified into groups by pathology and age. R e s u l t s . The scientific article reflects the results of the study of assessing the quality of life of working-age patients with the chronic respiratory system pathology. The analysis of the data revealed statistically significant differences in age, gender and groups of pathologies among the respondents. Differences in indicators reflecting emotional states were revealed among men and women of the working age. Age-related changes in indicators of physical and psychological components of health and on all scales of the quality of life were presented. The obtained values of patient indicators show the need to develop specific measures to reduce behavioral risk factors for chronic non-infectious respiratory diseases of the population of the Nizhny Novgorod region. Findings. The comparative analysis of the results of the scales of the quality of life and health components reflects the age-related changes in indicators. The people of the older age group of the working age demonstrate significantly low results. The indicators of physical functioning are statistically significantly different in different pathologies of the respiratory system. Chronic obstructive pulmonary disease (COPD) restricts the physical activity of patients more strongly than other pathologies. Low values of the quality of life reflect the need to develop the measures to reduce the risk factors for chronic non-infectious diseases for the population of the Nizhny Novgorod region.
Investigating Minimum Exposure Time Requirements of Diquat for Flowering Rush (Butomus umbellatus) Control
Authors: Sartain Bradley T. , Getsinger Kurt D.
Published: June 2023

The purpose of this study was to investigate the minimum exposure time requirements for submersed treatments of diquat to effectively control flowering rush (Butomus umbellatus L.). Identifying these parameters will provide critical information for the operational management of this species in high water exchange scenarios.
French Version of the Musculoskeletal Pain Intensity and Interference Questionnaire for Professional Orchestra Musicians (MPIIQM-F): Cross-Cultural Adaptation and Preliminary Validation
Authors: Roos Marianne , Dubé Marc-Olivier , Dupuis Frédérique , Lamontagne Marie-Eve , Roy Jean-Sébastien
Published: June 2023

BACKGROUND: The Musculoskeletal Pain Intensity and Interference Questionnaire for Professional Orchestra Musicians (MPIIQM) is a prominent patient-reported outcome measure (PROM) in the musicians’ health literature. It has been published in at least four languages, but not in
French. AIMS: To cross-culturally adapt the MPIIQM into French and establish the preliminary psychometric properties (validity, reliability, and responsiveness) of the MPIIQM-F. METHODS: Standardized cross-cultural adaptation methods included forward translations, an expert committee, and
verbal field tests in the target population. Psychometric properties were assessed in a population of French-speaking professional orchestra musicians who participated in three evaluation sessions. Evaluated properties include content, face, structural and construct validity, reliability (internal
consistency, test-retest reliability, minimal detectable change [MDC], measurement error), and responsiveness (effect size and standardized response means [SRM]). RESULTS: Sixty-one French-speaking orchestra musicians participated in the psychometric validation. Exploratory factor analysis
revealed a two-factor solution equivalent to previous versions, confirming the Pain Intensity and Interference subscales. Spearman correlations for construct validity were as hypothesized for four of six hypotheses (minor deviances for the other two hypotheses) using the Brief Pain Inventory,
Disability of the Arm, Shoulder and Hand Performing Arts Module, and PROMIS Global Health Scale as comparators. Reliability results demonstrated high internal consistency (Cronbach’s a=0.84–0.89), excellent test-retest reliability (intraclass correlation coefficient = 0.91–0.97),
and small measurement error with MDC for the overall scale <10%. Responsiveness resulted in moderate to large effect sizes and SRM (0.54–0.87). CONCLUSIONS: Preliminary validation of the MPIIQM-F suggests good validity, reliability, and responsiveness, indicating its suitability for
use in French-speaking orchestra musicians.
A ROWELLELLA (LINGULATA, BRACHIOPODA) NESTLER IN A TRYPANITES BORING FROM THE MIDDLE ORDOVICIAN OF ESTONIA: AN EARLY COLONIZER OF HARD SUBSTRATE BORINGS
Authors: VINN OLEV, , HOLMER LARS E., , WILSON MARK A., , ISAKAR MARE, , TOOM URSULA,
Published: June 2023

A steinkern of an endoceratid nautiloid siphuncle contains a Trypanites sozialis boring with a lingulate brachiopod Rowellella sp. shell inside. The steinkern of this endoceratid formed during early lithification of the sediment on the seafloor. The lithified steinkern of this siphuncle was either initially partially exposed to the seawater or was exhumed and stayed exposed on the seafloor, where it was colonized by boring organisms. This bioerosion resulted in numerous Trypanites borings in the siphuncle. After the death or exit of the Trypanites trace maker, a vacant boring was colonized by a small lingulate nestler Rowellella sp. This lingulate was likely preadapted to life in hard substrate borings when it first found its way into borings in living substrates in the Late Ordovician. The increased availability of hard substrate borings, combined with the increased predation pressure due to the GOBE, enhanced the colonization of hard substrate borings by lingulate brachiopods.
Pengaruh Eq, Iklim, dan Kepemimpinan Kepala Madrasah terhadap Kinerja Guru
Authors: Savitri Diva , Elfi Yuliani Rochmah  , Andhita Dessy Wulansari  , Ahmadi Ahmadi
Published: June 2023

This research is motivated by the teacher performance issue at MI Plus Al-Islam Dagangan Madiun. This issue is indicated by the fact that there are still approximately 35% of teachers who are incapable of properly controlling the class, as well as the lack of teacher sensitivity and commitment to students during the teaching and learning process. In addition, in terms of preparing lesson plans, several teachers have not fully prepared the lesson plans properly. This study aims to find out the significance of the influence of the Madrasah Principal's leadership, madrasah climate, and teacher’s Emotional Intelligence on teachers' performance in MI Plus Al-Islam Dagangan Madiun for the 2022/2023 Academic Year. This study uses a quantitative approach with ex post facto methods. The population is all teachers at MI Plus Al-Islam Dagangan Madiun, totaling 80 people. The sampling technique used is saturated samples. Meanwhile, the data analysis technique uses simple and multiple linear regression analysis. The results of the analysis show: the leadership of the Madrasah Principal, the climate of the madrasah, and the teacher's Emotional Intelligence have a significant effect on teachers' performance in MI Plus Al-Islam Dagangan Madiun for the 2022/2023 Academic Year, with around 55.1%.
Perempuan dan Akses Ekonomi: Menelaah Program MAMPU di Indonesia
Authors: Khasanah Uswatul
Published: June 2023

Gender menjadi masalah apabila terjadi perbedaan (diskriminasi) perlakuan dalam akses, partisipasi, kontrol dalam menikmati hasil pembangunan antara laki-laki dan perempuan. Perbedaan antara laki-laki dan perempuan dalam hal gender menyebabkan ketidakadilan gender yang mayoritas menimpa kaum perempuan. Salah satu ketidakadilan gender ini termanifestasi dalam bentuk marginalisasi. Marginalisasi yaitu proses peminggiran atau pemiskinan perempuan yang mengakibatkan kemiskinan. Sebagai upaya menghadapi kemiskinan, Indonesia bekerjasama dengan Australia membuat program MAMPU. Program ini dilaksanakan oleh mitra mampu yaitu ILO dibantu oleh YASANTI sebagai organisasi mitra di tingkat wilayah. Dalam melaksanakan program haruslah mengedepankan kesetaraan dan keadilan gender, yang dalam hal ini disebut dengan pengarusutamaan gender. Pengarusutamaan gender telah diatur dalam Instruksi Presiden Nomor 9 Tahun 2000. Selanjutnya penelitian ini bertujuan untuk menelaah program MAMPU yang telah dilaksanakan YASANTI di Kabupaten Bantul, Kulon Progo dan Sleman perspektif evaluasi yang merupakan salah satu aspek pengarusuatamaan gender. Penulisan artikel ini menggunakan metode kepustakaan. Dengan sumber data berupa buku, laporan penelitian, peraturan perundang-undangan dan website resmi yang membahas program MAMPU. Hasil penelitian ini menunjukkan bahwa program MAMPU yang dilaksanakan oleh YASANTI telah menunjukkan keberhasilan, hal itu terlihat dari hasil evaluasi program, evaluasi hasil, dan evaluasi dampak. Namun, dalam evaluasi proses, variabel budaya menjadi penghambat keberhasilan program ini.
INOVASI PRODUK PUDING DURIAN UNTUK MENINGKATKAN INCOME PERKAPITA MASYARAKAT DESA GAMBIRAN,TULUNGAGUNG
Authors: Rosyida Fatia Ainur , Ahmadi Ahmadi
Published: June 2023

Potensi yang terdapat di desa Gambiran,Kecamatan Pagerwojo,Kabupaten Tulungagung termasuk banyak sekali, salah satunya adalah buah durian yang pohonnya berada di sekitar rumah warga. Ketika musim panen telah tiba, para masyarakat lebih memilih untuk menjualnya saja dan tidak ada ide pengolahan dengan inovasi lain karena mayoritas warga Gambiran juga memiliki sapi perah yang dianggap lebih banyak menghasilkan keuntungan. Berdasarkan permasalahan tersebut, maka tim dari peserta pengabdian berinisiatif untuk mengadakan inovasi pengolahan buah durian menjadi pudding durian dengan menggunakan metode ABCD (Asset Based Community Development). Adapun proses pendampingan dilaksanakan mulai dari sosialisasi pemberian materi tentang kewirausahaan, sosialisasi produk, sosialisasi pengemasan dan sosialisasi pemasaran produk pudding durian. Kegiatan ini berlangsung dengan lancar dan diharapkan dapat memberi pemahaman tentang berwirausaha yang luas, dapat dijadikan sebagai peluang untuk usaha bagi masyarakat, dapat menambah rasa ketertarikan masyarakat untuk menjadikan produk karya desa dengan pemasaran yang tepat sehingga dapat mengembangkan berbagai inovasi serta kreativitas masyarakat dengan pendapatan yang meningkat
PENDAMPINGAN MELALUI PELATIHAN SEKOLAH RAMAH ANAK DI SD KARAKTER GENIUS ISLAMIC SCHOOL
Authors: Susanto Susanto
Published: June 2023

Seiring dengan tingginya kasus pelanggaran terhadap anak di satuan pendidikan, model sekolah ramah anak merupakan solusi untuk pencegahan segala bentuk pelanggaran terhadap anak. SD Karakter Genius Islamic School Kota Depok memiliki beragam potensi yang memadai yang dapat dikembangkan untuk penerapan model sekolah ramah anak. Pemilihan sekolah ini berdasarkan pertimbangan sebagai berikut; pertama, komitmen kepemimpinan yang memadahi dan inovatif; kedua, kompetensi pendidik dan tenaga kependidikan sangat mendukung; ketiga, nilai-nilai dan kultur sekolah berbasis karakter, sehingga relevan dengan penerapan model sekolah ramah anak. Pengabdian ini menggunakan pendekatan Asset Based Community Development (ABCD). Adapun langkah-langkah pendampingan program ini meliputi: 1) observasi lingkungan sekolah, 2) koordinasi pimpinan sekolah, 3) pelatihan penerapan model sekolah ramah anak, 4) pelaksanaan program, dan 5) monitoring dan evaluasi. Sedangkan penerapan model sekolah ramah anak mengacu pada 6 (enam) indikator yaitu aspek kebijakan, pendidik dan tenaga kependidikan, proses pembelajaran, partisipasi anak, sarana dan prasarana serta partisipasi orangtua.
PENINGKATAN MANAJEMEN PENGAJARAN DI TPQ ROUDLOTUL MUHAJIRIN DESA WRINGINANOM KECAMATAN SAMBIT KABUPATEN PONOROGO
Authors: Agnibaya Rangga , Agustina Nur Arista Melanoi , Rosida Rifqia Kholifatu
Published: June 2023

Taman Pendidikan Al-Qur’an (TPQ) Roudlotul Jannah berada di Dusun Nambang, Desa Wringinanom, Kecamatan Sambit, Kabupaten Ponorogo. Keberadaan TPQ ini memberikan dampak yang baik untuk masyarakat sekitar, di mana dampak positif ini juga dipengaruhi oleh sistem pengajaran yang diterapkan. Menyadari akan banyaknya pendidik dan juga siswa-siswinya, pengabdi berpandangan betapa besar potensi yang dapat diberikan oleh TPQ Roudlotul Jannah kepada masyarakat Dusun Nambang. Akan tetapi, pengabdi menemukan adanya pengelolaan manajemen kelas yang belum maksimal dan juga dari hasil pengamatan pengabdi, ditemukan bahwa cara atau metode pengajaran para pengajar kurang maksimal. Kekurangan tersebut terkait metode pendekatan pendidik kepada peserta didik. Pada dasarnya, cara pengajar dalam melakukan pendekatan kepada peserta didik itu penting dilakukan guna menunjang keberhasilan dalam penyampaian materi dan juga tujuan yang indin dicapai lembaga. Melihat kanyataan seperti ini, pengabdi berinisiatif untuk melaksanakan program dalam rangka peningkatan kemampuan mendidik dan manajemen pengelolaan kelas. Program tersebut terimplementasikan dalam wujud seminar yang ditujukan untuk pengajar di TPQ Roudlotul Muhajirin. Dengan adanya program yang diinisiasi oleh pengabdi, diharapkan proses pengajaran di TPQ akan berjalan maksimal dan terorganisir dengan baik, sehingga hal ini akan memberikan kebermanfaatan yang lebih terhadap Dusun Nambang.
Bi, Python and Low Code Applications to Accelerate Digital Transformation
Authors: Heine S. , Castillo O. A. , Palacios M. R. , López C. , Castello M. E. , Albarracín H. , Serrano G. D.
Published: June 2023

Citizen developer teams can be a valuable asset to any organization as they can help drive innovation and increase efficiency by quickly building custom solutions to meet specific business needs. They can also help bridge the gap between IT and business teams, allowing for more collaboration and better alignment of technology with business goals.

Overall, citizen developer teams are a way for organizations to tap into the collective knowledge and expertise of their employees, empower them to drive digital transformation and improve business processes.

This presentation aims to illustrate the importance of having such hybrid teams in any organization. By empowering non-technical employees to create custom software solutions, organizations can access a diverse range of knowledge and expertise to meet the needs of all stakeholders. DataGMA exemplifies this approach, having successfully improved data-driven processes at YPF Upstream NOC through the development and implementation of short-term Digital Solutions. By utilizing microservice principles and agile methodologies, DataGMA has made a significant impact on the organization, fostering a culture of data-driven decision making and improving various business processes.

Specifically, DataGMA is a YPF Upstream NOC multidisciplinary team that combines geoscientists with technical support to deliver short-term solutions using Python and Low Code Platforms.

While IT manages main and corporate applications according to corporate priorities and scope, DataGMA can take on new challenges and provide targeted solutions for short-term needs.

Historical data was officially safeguarded and made available through new workflows, via optimized formats. Many manual tasks were replaced by automatic processes and many Python applications were created to optimize the interpretations of physical phenomena, with minimal cost. Finally, work methodologies and reporting of various disciplines were optimized through a combination of dashboards and low code application building.

Throughout 3 years, DataGMA has improved many business processes by tackling non-governed data and building data awareness. This has radically improved engagement around the data life cycle and reduced time of no valuable work, such as repetitive or inefficient tasks. With a dynamic approach, the team was able to solve, not only recurrent business problems but new challenging ones, which has helped with digital transformation transition. DataGMA is an example of how a group of citizen Developers, included in a team with access to digital technologies, can achieve a direct impact on business performance.
Determination of Rock Compressibility in Unconsolidated Sand in Heavy and Extra-Heavy Oil Fields in Mexico
Authors: Fragoso A. , Aguilera R. , Cinco-Ley H.
Published: June 2023

Unconsolidated sands in heavy and extra-heavy oil fields in Mexico have significant potential that has not been fully evaluated yet. Thus, this paper examines petrophysics and geomechanical aspects with a view to estimating rock compressibility. This is important since determining this parameter from cores has proved to be difficult many times as the samples tend to collapse easily during laboratory experiments.

The proposed method uses an empirical correlation for estimating Biot coefficient (Li et al., 2020) and more established geomechanical equations written in such a way as to allow the estimation of several types of compressibilities including: bulk compressibility, uniaxial bulk compressibility, pore compressibility, uniaxial pore compressibility, and pore compressibility under hydrostatic load. The data are loaded on a Pickett plot (1966, 1973) to demonstrate the value of pattern recognition.

There are several intermediate results from calculations leading to the compressibilities mentioned above. These include process speed (ratio of permeability and porosity), pore throat aperture in microns at 35 percent cumulative pore volume (rp35), water saturation (Sw), mercury-air capillary pressure (pc), pore throat apertures (rp) at different water saturations, Biot coefficient (α), Poisson's ratio (PR), shear modulus (G), Young's modulus (YM), and fluid compressibility (cf).

An important observation is that although use of the equations presented in the paper are straight forward and lead to quick calculation of all parameters mentioned above, it is likely that calculations from well logs without using pattern recognition may lead to uncertain results.

The novelty of the paper is developing a methodology for calculating diverse types of rock compressibilities in unconsolidated sandstone reservoirs. Application of the methodology can lead to improved calculated recovery factors of unconsolidated sandstone reservoirs in heavy and extra-heavy oil fields in Mexico by at least 10%.
Fast Real-Time Production Optimization for Integrated Asset Modelling Using Mixed-Integer Non-Linear Programming in Julia Language
Authors: Canchucaja Ramiro
Published: June 2023

This study proposes a method for integrated asset modelling by using machine learning along with operations research algorithms to perform real-time constrained production optimization and maximize operational profit in a real-time basis.

The methodology, which is mainly about the transformation of field and well performance to equations, inequalities, and matrixes, was tested successfully in the operation of a gas condensate field where operational profit increased, in abnormal conditions when personnel normally act mostly based on experience, pre-conceived notion, or solutions to previously solved problems. The study provides a solution with full data-driven objectivity for decision-making using the results of a mixed integer non-linear programming problem.
Going from Days to Hours: A Digital Journey to Optimize Barrels and Improve Work-Life Balance
Authors: Batallas E. , Gallegos J. , Seadi G. Tagarot , Campana D. , Vargas A. , de la Bastida M. A. Hernandez , Florez F.
Published: June 2023

The Choke Model is an approach to determine well potential after considering all the production system constraints. It is designed to identify production losses, network bottlenecks, and optimization opportunities. This paper shares the digital generation of the Choke Model for a mature field. The core components of the model are production potential estimate; production accounting; shortfall accounting and opportunities materialization. The solution leverages the already deployed cloud systems to define the individual choke capacity —reservoir, well, plant, export and, commercial—. A combination of in-house coding and industry-standard software solutions set a new path to add value with digital capabilities and offers.

The solution automated the Asset's choke model using python codes, compiling results in an interactive dashboard with the most frequent —usually daily— updated production potential. The dashboard grouping and analytics allows quick visualization of opportunities, (i.e. workover candidates such as matrix stimulations, hydraulic fractures and reperforation jobs). The impact included rising awarness of capacity constraints along production system, prioritization based on feasible execution; and better work-life balance for team members; with the corresponding monetary surplus.
Friction and Casing Wear Factor Characterization
Authors: Barreto Jose Alberto , Grittini Santiago Javier , Zambetti Raffaello , Zara Emanuel Mariano , Tuckart Walter
Published: June 2023

Casing wear is a concern among O&G operators worldwide since it can lead to well integrity issues. Wear can appear on both elements, drill pipe and the external casing, resulting in the reduction of the tubular wall thickness affecting its performance. To address the topic, a tribometer was developed based on the standard API STD 7CW (2015), including a rotating element that slides against a fixed element while being exposed to drilling mud, leading to the obtention of coefficients of friction (CoF) and casing wear factors, for different combinations of Oil Country Tubular Goods (OCTG).

To estimate CoF and casing wear factors, more than 70 laboratory tests were performed combining steel grades under repetitive and consistent conditions. Contact force was fixed and maintained between both elements during test. CoF were calculated by direct torque measurement, while casing wear factors were indirectly defined by measuring the material loss volume.

Results obtained in CoF were in a range of 0.3 and 0.5, being higher than the values in open literature. They also showed a relation between drill element grades and higher values of CoF. Three zones were detected when evaluating CoF results together. Analyzing casing wear factors, the results obtained were in a range from 0.03 to 0.3 (1/psi E-09), this range is slightly lower than public data available. Different testing conditions such as torque and displacement were evaluated to assess the behavior of 28Cr alloy.
A controlled evaluation of social prescribing on loneliness for adults in Queensland: 8-week outcomes
Authors: Dingle Genevieve A. , Sharman Leah S. , Hayes Shaun , Haslam Catherine , Cruwys Tegan , Jetten Jolanda , Haslam S. Alexander , McNamara Niamh , Chua David , Baker J. R. , Johnson Tracey
Published: June 2023

Background
There have been few controlled evaluations of Social Prescribing (SP), in which link workers support lonely individuals to engage with community-based social activities. This study reports early outcomes of a trial comparing General Practitioner treatment-as-usual (TAU) with TAU combined with Social Prescribing (SP) in adults experiencing loneliness in Queensland.
Methods
114 individuals were non-randomly assigned to one of two conditions (SP, n = 63; TAU, n = 51) and assessed at baseline and 8 weeks, on primary outcomes (loneliness, well-being, health service use in past 2 months) and secondary outcomes (social anxiety, psychological distress, social trust).
Results
Retention was high (79.4%) in the SP condition. Time x condition interaction effects were found for loneliness and social trust, with improvement observed only in SP participants over the 8-week period. SP participants reported significant improvement on all other outcomes with small-to-moderate effect sizes (ULS-8 loneliness, wellbeing, psychological distress, social anxiety). However, interaction effects did not reach significance.
Discussion
Social prescribing effects were small to moderate at the 8-week follow up. Group-based activities are available in communities across Australia, with data here suggesting that they offer accessible and tailored solutions to meet individual psychosocial needs.
Trial registration
ANZCTR, Retrospectively registered 08/06/2022, https://www.anzctr.org.au/ACTRN12622000801718.aspx
Litter isopod mouthpart traits respond to a tropical forest recovery gradient
Authors: Ang Shawn B. H. , Lam Weng Ngai , Png G. Kenny , Tan Sylvia K. B. , Lee Benjamin P. Y-H. , Khoo Max , Luskin Matthew S. , Wardle David A. , Slade Eleanor M.
Published: June 2023

Functional trait ecology has the potential to provide generalizable and mechanistic predictions of ecosystem function from data of species distributions and traits. The traits that are selected should both respond to environmental factors and influence ecosystem functioning. Invertebrate mouthpart traits fulfil these criteria, but are seldom collected, lack standardized measurement protocols, and have infrequently been investigated in response to environmental factors. We surveyed isopod species that consume plant detritus, and tree communities in 58 plots across primary and secondary forests in Singapore. We measured body dimensions (body size traits), pereopod and antennae lengths (locomotory traits), dimensions of mandible structures (morphological mouthpart traits), and mechanical advantages generated by mandible shape (mechanical mouthpart traits) for six isopod species found in these plots and investigated if these traits respond to changes in tree community composition, tree diversity, and forest structure. Morphological mouthpart traits responded to a tree compositional gradient reflecting forest recovery degree. Mouthpart features associated with greater consumption of litter (broader but less serrated/rugose lacinia mobilis [an important cutting and chewing structure on the mandible]) were most prevalent in abandoned plantation and young secondary forests containing disturbance-associated tree species. Feeding strategies associated with fungi grazing (narrower and more serrated/rugose lacinia mobilis) were most prevalent in late secondary forests containing later successional tree species. Since morphological mouthpart traits likely also predict consumption and excretion rates of isopods, these traits advance our understanding of environment–trait–ecosystem functioning relationships across contrasting tropical forest plots that vary in composition, disturbance history and post-disturbance recovery.
The “Look! - your baby is talking to you” intervention study aiming to reduce post-partum depressive symptoms among vulnerable mothers: A process evaluation.
Authors: Ejlertsen Camilla , Kristensen Ingeborg Hedegaard , Voltelen Barbara , Brødsgaard Anne
Published: June 2023

Background: A successful early parent-infant interaction may be threatened by maternal anxiety or depression. The obstetric department's healthcare professionals are in a unique position to initiate early intervention. Early interventions and short-term programmes aiming to improve mother-infant interaction have shown to be successful. This study aimed to evaluate the intervention study “Look! – Your baby is talking to you” with the primary aim of lowering maternal postnatal depression symptoms three months after birth. The intervention adopted a relationship-based approach in a family-oriented context and aimed to optimise transition to primary healthcare for vulnerable families. The intervention components included the Newborn Behavioral Observations System, family-focused nursing, and a systematic transition to primary healthcare.
Methods: By examining implementation, i.e., reach, dose, fidelity, and mechanisms of impact of the intervention "Look! – Your baby is talking to you", we evaluated the intervention study using the UK Medical Research Council process evaluation framework. The contextual considerations and adaptations made to ensure implementation were in focus of the evaluation.
Results: The intervention “Look! – your baby is talking to you” reached the intended target group of vulnerable mothers with previous or current depression and/or anxiety. In the intervention group, 47 women completed the follow-up questionnaires; in the non- intervention group, 51 women responded to the questionnaires. The intervention dose was delivered as intended with high fidelity, proving that the healthcare professionals increased knowledge, intention, skills, and self-efficacy in relation to postnatal care after Newborn behavioural observation training. Mechanisms of impact reflected mixed effect results. However, both the primary (maternal depressive symptoms) and the secondary outcomes (maternal stress, reflective function, and family function) tended to favour the intervention group.
Conclusion: Overall, the intervention was applicable to clinical practice. It was feasible and had high participation. Furthermore, the process evaluation revealed potential facilitators and barriers to the targeted processes, which is essential knowledge for future evaluation of the effects of the intervention.
Trial registration:
ClinicalTrials.gov ID: NCT04169334, Registered 19 November 2019.
Neurosyphilis presenting with Guillain-Barre Syndrome: A Case Report
Authors: Ung Hoameng , Ferrey Dominic
Published: June 2023

Background
Syphilis is associated with a wide variety of different systemic presentations, earning it the moniker “The great mimicker”. Neurosyphilis is classically associated with meningovasculitis in the acute-subacute stage and tabes dorsalis and dementia paralytica in later stages. However, one of the less well described presentations includes Guillain-Barre Syndrome. This case presents a patient with neurosyphilis who developed with an ascending polyneuropathy with electrodiagnostic testing consistent with demyelination, supporting a diagnosis of neurosyphilis associated Guillain-Barre Syndrome.
Case presentation
A 37-year-old female presented to the emergency department with a weakness and difficulty swallowing. She described a three-month history of symptoms, initially starting with a persistent headache followed by one month of a pruritic rash on her chest, palms, and soles. Two weeks ago, she developed weakness in her arms, numbness in her arms and chest, and for the last two days, difficulty swallowing. Neurological exam was notable for multiple cranial neuropathies, distal greater than proximal upper and lower extremity weakness, length-dependent sensory loss, and hyporeflexia. Investigation revealed a positive Venereal Disease Research Laboratory in her cerebrospinal fluid without pleocytosis, contrast enhancement in cranial nerve V, VII, and VIII on MRI, and a demyelinating polyneuropathy on electrodiagnostic testing. She was diagnosed with Guillain-Barre syndrome, secondary to neurosyphilis. The patient acutely declined and required intubation, and ultimately made a full recovery after treatment with plasmapheresis and penicillin.
Conclusions
This case describes a clinical entity of syphilitic Guillain-Barre Syndrome and highlights the importance of including syphilis in the differential of a patient presenting with ascending polyradiculopathy, especially given the resurgence of syphilis.
Metabolic composition of endophytes contributed to the effect of Brassica rapa L. in improving immunity
Authors: Wei Jie , Wu Jianyong , Wei Yurong , Yimiti Dlixiati , Mi Xiaoyun
Published: June 2023

Background.
As a medicinal plant, Brassica rapa L. contains various valuable metabolites and endophytes, and has been widely used in Northwest China. However, the detailed contributions of endophytes to the mechanisms of Brassica rapa L. improving immunity were still unknown. Previously, we isolated four endophyte fungi from Brassica rapa L..
Methods.
In this study, we identified the effect of endophytes of metabolites of Brassica rapa L. and its extracts in improving immunity through triggering genes relevant to NF-kB and inflammatory pathways. Then, we performed GC-MS metabolomics to analyze the metabolic variations among these four endophytes.
Results.
The results showed that the metabolic compositions of PR10 significantly varied from other three endophytes. PR10 is rich in amino acids, which may affect amino acids compositions of Brassica rapa L.. And the PR10 extracts highly activated genes involved in NF-κB and inflammatory pathways, reaching a consensus with the effect of Brassica rapa L.. And the dominant metabolites of PR10 were also closely associate with various diseases, including pyruvate dehydrogenase deficiency, Heart failure and various Inflammatory diseases. Thus, Brassica rapa L. may improve the inflammatory-related diseases and immunity through its specific metabolic compositions associated with endophyte PR10. Typically, trehalose was the main metabolites that made contributions to the immune-promotion effects of PR10 and Brassica rapa L.. In conclusion, metabolites highly produced by PR10 explained the medicinal value of Brassica rapa L. in improving immunity.
Continuous nerve block versus thoracic epidural analgesia for post-operative pain of pectus excavatum repair: A systematic review and meta-analysis
Authors: Chen Li-Jung , Chen Shih-Hong , Hsieh Yung-Lin , Yu Po-Chuan
Published: June 2023

Surgery to repair pectus excavatum (PE) is often associated with severe postoperative pain, which can impact the length of hospital stay (LOS). While thoracic epidural analgesia (TEA) has traditionally been used for pain management in PE, its placement can sometimes result in severe neurological complications. Recently, paravertebral block (PVB) and erector spinae plane block (ESPB) have been recommended for many other chest and abdominal surgeries. However, due to the more severe and prolonged pain associated with PE repair, it is still unclear whether continuous administration of these blocks is as effective as TEA. Therefore, we conducted this systematic review and meta-analysis to demonstrate the equivalence of continuous PVB and ESPB to TEA.
Broadly neutralizing antibodies against Zika virus from dengue patients with prior exposure to Japanese encephalitis virus
Authors: Salem Gielenny , Galula Jedhan , Wu Shang-Rung , Liu Jyung , Chen Yen-Hsu , Wang Wen-Hung , Wang Sheng-Fan , Song Cheng-Sheng , Chen Fan-Chi , Wang Cheng-Yi , Chao Day-Yu
Published: June 2023

Exposure to multiple mosquito-borne flaviviruses within a lifetime is not uncommon; however, how sequential exposures to different flaviviruses shape the cross-reactive (CR) humoral response against an antigen from a different serocomplex has yet to be explored. Here, we report that dengue-infected individuals initially primed with the Japanese encephalitis virus (JEV) showed broadly highly neutralizing potencies against the Zika virus (ZIKV). We also identified a rare class of ZIKV CR human monoclonal antibodies (huMAbs) with increased somatic hypermutation and broad neutralization against multiple flaviviruses. One huMAb, K8b, binds quaternary epitopes with heavy and light chains separately interacting with overlapping E dimer units spanning domains I, II, and III through cryo-electron microscopy and structure-based mutagenesis. Using JEV virus-like particle (VLP) immunization in mice further confirmed that such CR antibodies, mainly IgG3 isotype, can be induced and proliferate through heterologous DENV-2 VLP stimulation. Our findings provide novel insights for future vaccination strategies.
H2A.X promotes endosperm-specific DNA methylation in Arabidopsis thaliana
Authors: Frost Jennifer M. , Lee Jaehoon , Hsieh Ping-Hung , Lin Samuel J. H. , Min Yunsook , Bauer Matthew , Runkel Anne M. , Cho Hyung-Taeg , Hsieh Tzung-Fu , Fischer Robert L. , Choi Yeonhee
Published: June 2023

Background
H2A.X is an H2A variant histone in eukaryotes, unique for its ability to respond to DNA damage, initiating the DNA repair pathway. H2A.X replacement within the histone octamer is mediated by the FAcilitates Chromatin Transactions (FACT) complex, a key chromatin remodeler. FACT is required for DEMETER (DME)-mediated DNA demethylation at certain loci in Arabidopsis thaliana female gametophytes during reproduction. Here, we sought to investigate whether H2A.X is involved in DME- and FACT-mediated DNA demethylation during reproduction.
Results
H2A.X is encoded by two genes in Arabidopsis genome, HTA3 and HTA5. We generated h2a.x double mutants, which displayed a normal growth profile, whereby flowering time, seed development, and root tip organization, S-phase progression and proliferation were all normal. However, h2a.x mutants were more sensitive to genotoxic stress, consistent with previous reports. H2A.X fused to Green Fluorescent Protein (GFP) under the H2A.X promoter was highly expressed especially in newly developing Arabidopsis tissues, including in male and female gametophytes, where DME is also expressed. We examined DNA methylation in h2a.x developing seeds and seedlings using whole genome bisulfite sequencing, and found that CG DNA methylation is decreased genome-wide in h2a.x mutant seeds. Hypomethylation was most striking in transposon bodies, and occurred on both parental alleles in the developing endosperm, but not the embryo or seedling. h2a.x-mediated hypomethylated sites overlapped DME targets, but also included other loci, predominately located in heterochromatic transposons and intergenic DNA.
Conclusions
Our genome-wide methylation analyses suggest that H2A.X could function in preventing access of the DME demethylase to non-canonical sites. Alternatively, H2A.X may be involved in recruiting methyltransferases to those sites. Overall, our data suggest that H2A.X is required to maintain DNA methylation homeostasis in the unique chromatin environment of the Arabidopsis endosperm.
Incorporating Metaheuristic Optimization Algorithm ABO for Improvement of LEACH Protocol in Wireless Sensor Networks
Authors: Malik Monika , Josh Alok , Sakya Gayatri
Published: June 2023

The principal application of Wireless Sensor Network (WSN) is to perform sensing and tracking in the scenarios where continuous monitoring is required. At the same time tiny sensor node consumes energy in performing these tasks resulting in reduced performance of WSN due to signal loss and packet transmission. Many techniques were developed to overcome the issues of high energy consumption nodes but still have a problem identifying cluster heads since packet loss and signal transmission occurs during transmission. . This paper integrates a metaheuristic optimization algorithm to improve the performance of WSN. The metaheuristic African Buffalo-based Energy Optimized LEACH Protocol (MABEOLP) is designed to enhance communication performance in WSN. The proposed scheme recognize the less energy and high energy consumption nodes at an earlier stage of the energy-aware phase and the high energy consumption nodes are neglected .At the same time a temporary route is developed to avoid sudden signal failure and packet drop. The optimized model is implemented in Matlab ,it is tested for maximum of 125 nodes and later the performance parameters energy consumption, delay, throughput, packet transmission rate, and packet loss are compare with the existing methods.
Linum usitatissimum oil Fraction Reverse Cardiac Remodeling at Molecular level: Suppressing miRNA-29b and miRNA 1 genes in Isoproterenol In vivo Model
Authors: Boshra Sylvia A , Nazeam Jilan A.
Published: June 2023

Linum usitatissimum (flaxseed) produce one of the oldest commercial oils which use traditionally as a functional food for lowering cholesterol level. Nevertheless, to date, there is no scientific evidence to assess the role of flaxseed oil in cardiac remodeling management. The study aimed to clarifying the underlying mechanism of standardized oil to restore cardiac remodeling in a heart toxicity rat model induced by isoproterenol (ISO). Oil fraction was purified, and major components were identified by gas-chromatography-mass spectrometry (GC-MS). The in vivo tests were conducted by ISO (85 mg/kg/ twice subcutaneously) with 24 hours between each dose. The rats were treated with flaxseed oil fraction (100 mg/kg orally) and the same dose was used for omega 3 as a positive control group. GC- MS revealed that α-linolenic acid (24.6%), oleic acid (10.5%), 6-octadecenoic acid (Z), 2,3 dihydroxypropyl ester (9.0%), 2,3-dihydroxypropyl elaidate (7.0%), n-propyl 9,12,15-octadecatrienoate (6.0%) are the major components. After 4 weeks of oil uptake, the results revealed an improvement in cardiac function, a decrease in apoptosis, and simultaneous prevention of myocardial fibrosis. The levels of BNP, NT-pro-BNP, endothelin-1, Lp-PLA2, and MMP2, and cTnI and cTn were significantly decreased, and a higher plasma level of Topo 2B was observed, moreover, miRNA − 1 and 29b were downregulated. Current evidence provide insight into the mechanism of flaxseed oil to restore cardiac remodeling, which supports its future application as cardioprotective against heart diseases.
Using the Community Perception Tracker to inform COVID-19 response in Lebanon and Zimbabwe: A qualitative methods evaluation
Authors: Majorin Fiona , Jain Anika , Haddad Christine El , Zinyandu Eddington , Gharzeddine Ghassan , Chitando Mutsawashe , Maalouf Aline , Sithole Ntandoyenkosi , Doumit Rita , Azzalini Raissa , Heath Thomas , Seeley Janet , White Sian
Published: June 2023

Background
Despite the recognized importance of community engagement during disease outbreaks, methods describing how to operationalise engagement are lacking. The Community Perception Tracker (CPT) was designed by Oxfam to systematically record real-time information on disease perceptions and outbreak response actions in order to adapt programmes.
Methods
We conducted a phased, qualitative methods, process evaluation in Zimbabwe and Lebanon to understand whether the CPT approach was a feasible way to incorporate community perceptions into COVID-19 response programming and whether this resulted in more relevant programming. We conducted 3 rounds of interviews with 15 staff using the CPT, analysed programmatic data, and conducted multiple rounds of phone-based interviews with outbreak-affected populations (50 participants per country). Qualitative data were thematically analysed and quantitative data descriptively summarized.
Results
Initially CPT implementing staff struggled to differentiate how the CPT differed from other monitoring tools that they were familiar with and felt that the training did not convey the full process and its value. However, with practise, collaboration and iterative improvements to the recommended CPT steps, staff found the process to be feasible and a significant value-add to their programming. Staff initially focused more on quantitively summarizing perceptions but eventually developed processes for maximizing the qualitative data on perceptions too. Trends emerging from the CPT led to frequent programmatic tweaks to COVID-19 messaging and product distributions. Emergent trends in perceptions also led staff to work cross-sectorally and advocate to other actors on behalf of populations. Outbreak-affected populations exposed to the programmes reported high levels of knowledge about COVID-19 and reported they practiced preventative behaviours, although this waned with time. Most population members also felt the COVID-19 programmes were relevant to their needs and said that non-government organisations were a trusted source of information.
Conclusions
The CPT appears to be a promising approach for ensuring that community engagement is undertaken systematically and that community perspectives are actively incorporated to improve programming. While crisis-affected populations generally found the programmes to be useful and relevant and to have influenced their knowledge and behaviours, it is not possible to attribute this to the CPT approach due to the study design.