bluuebunny/crossref_metadata_2025 huggingface dataset:
The Cultural Ecohydrogeology of Mediterranean-Climate Springs: A Global Review with Case Studies
Authors: Pascual Roger , Piana Lucia , Bhat Sami Ullah , Castro Pedro Fidel , Corbera Jordi , Cummings Dion , Delgado Núñez Cristina , Eades Eugene , Fensham Roderick J. , Fernández-Martínez Marcos , Ferreira Verónica , Filippini Maria , García Guillermo , Gargini Alessandro , Hopper Stephen D. , Knapp Lynette , Lewis Ian D. , Peñuelas Josep , Preece Catherine , Resh Vincent H. , Romero Estela , Samraoui Boudjéma , Samraoui Farrah , Segadelli Stefano , Seiler Hallie , Skoulikidis Nikolaos Th. , Solak Cüneyt N. , Herce Jaume Solé , Villholth Karen G. , Wani Huma Khurshid , Cantonati Marco , Stevens Lawrence E.
Published: January 2024

Cultures in Mediterranean climate zones (MCZs) around the world have long been reliant on groundwater and springs as freshwater sources. While their ecology and cultural sustainability are recognized as critically important, inter-relationships between springs and culture in MCZs has received little attention. Here we augmented a global literature review with case studies in MCZ cultural landscapes to examine the intensity of cultural and socio-economic impacts on springs ecohydrogeology. MCZs are often oriented on the west and southern coasts in tectonically active landscapes, which control aquifer structure, the prevalence of westerly winds, and aridity, and generally expose associated habitats to harsh, afternoon sunlight. Cultural appreciation and appropriation of springs ranges widely, from their use as subsitence supplies to profound traditions, such as Greco-Roman nymphs, and Asian and Abrahamic spiritual cleansing and baptism. Commoditization of water resources for agriculture, industry (e.g., mining, water bottling, geothermal resorts), and urban needs is placing ever-increasing, non-sustainable demands on aquifers and springs. When economic values approach or exceed cultural values, these irreplaceable aquatic resources are degraded and lost. Sustainable stewardship of springs and the aquifers that support them are a little-recognized, but central conservation challenge for modern society facing global climate changes.
Research Progress of Atomically Dispersed Fe–N–C Catalysts towards Oxygen Reduction Reaction
Authors: Lian Yuebin , Xu Jinnan , Zhou Wangkai , Lin Yao , Bai Jirong
Published: January 2024

The efficiency and performance of Proton Exchange Membrane Fuel Cells (PEMFCs) are primarily influenced by ORR electrocatalysts. In recent years, atomically dispersed met-al-nitrogen-carbon (M-N-C) catalysts have gained significant attention due to their high active center density, high atomic utilization, and high activity. These catalysts are now considered the preferred alternative to traditional noble metal electrocatalysts. The unique properties of M-N-C catalysts are anticipated to enhance the energy conversion efficiency and lower the manufac-turing cost of the entire system, thereby facilitating the commercialization and widespread ap-plication of fuel cell technology. This article initially delves into the origin of performance and degradation mechanisms of Fe-N-C catalysts from both experimental and theoretical perspectives. Building on this foundation, the focus shifts to strategies aimed at enhancing the activity and durability of atomically dispersed Fe-N-C catalysts. These strategies encompass the use of bi-metallic atoms, atomic clusters, heteroatoms (B, S, and P), and morphology regulation to optimize catalytic active sites. The article concludes by detailing the current challenges and future pro-spects of atomically dispersed Fe-N-C catalysts.
Long-Term Quality of Life after COVID-19 Infection: A Cross-Sectional Study of Health Care Workers
Authors: Moussa Antar , Hansjoerg Ullerich , Andreas Zaruchas , Torsten Meier , Ricarda Diller , Ulrich Pannewick , Sameer Dhayat A.
Published: January 2024

Abstract: (1) Background: Post-COVID syndrome is defined as symptoms that occur simultane-ously with or after COVID-19 infection, last for 12 weeks, and are not due to another diagnosis. Limited data are available on people’s long-term quality of life (QoL) following COVID-19 infection. The aim of this cross-sectional study was to investigate long-term QoL after COVID-19 among employees of the St. Josef Hospital in Paderborn, Germany, and to identify risk factors. (2) Methods: A monocentric, cross-sectional study was conducted using the validated and digitized WHOQOL-BREF questionnaire via Netigate® between 10/2022 and 02/2023. Data on QoL and global health status were collected in the following four domains: physical health, mental health, social relationships, and environment. (3) Results: The response rate was 73.84% (923/1250). Furthermore, 63.45% of hospital staff respondents reported at least one persistent symptom after COVID-19 infection, leading to significant differences in QoL. Pre-existing conditions, persistent symptoms, and disability after COVID-19 infection, as well as high BMI, no partnership, and low educational level were found to significantly contribute to long-term low QoL. (4) Conclusions: Obesity, lack of partnership, and a low level of education were independent risk factors for lower QoL post-COVID-19 infection in this cohort of hospital staff. Further multicenter studies are re-quired to validate the incidence and their suitability as independent risk factors for post-COVID syndrome.
Increasing Household Income from Vegetable Farming through Mobile and Smartphones Apps
Authors: Hadiarto Agus , Firdaus Muhammad , Harianto Harianto , Novianti Tanti
Published: January 2024

This study aims to determine the impact of the type of ICT usage on household income from main vegetables, agriculture (including main vegetables), and total income. This study is based on surveys and interviews with vegetable farmers using structured questionnaires conducted in three villages in Indonesia, including Cianjur, Sleman, and Malang in West Java, Yogyakarta, and East Java, respectively. The data were collected from 375 respondents selected in each region from November 2021 to March 2022. An econometric model called the multivariate linear regression (MLR) model is used to assess heterogeneous factors that influence the possibility of increasing the income of vegetable farmers. The study found that variables that use ICT as a primary variable, household, marketing, geographical characteristics, and immediate source information in agriculture have a significant impact on household income (P < 0.01) from primary vegetables, agriculture, and total income, with multiple R squares of 70.5, 72.0, 73.7% and F statistics of 28.48, 30.66, and 33.34, respectively. In summary, this novel study shows that the five categories of information technology used in farming and selling of harvest have a positive impact on household incomes
A WKNN Indoor Fingerprint Localization Technique Based on Improved FD’s Discrimination Capability to PD
Authors: Wang Baofeng , Li Qinghai , Liu Jia , Wang Zumin , Yu Qiudong , Liang Rui
Published: January 2024

The weighted K-nearest neighbors (WKNN) algorithm has been widely used in indoor fingerprint localization, which utilizes fingerprint distance (FD) of pairwise positions to discriminate the physical distance (PD) between them. However, due to the varied states of different wireless access points (APs), their contribution to FD discrimination capability varies. In our study, we analyzed several critical causes that affect APs’ contribution, including AP’s health state, the distance, and the direction between APs and position pairs. Inspired by these insights, a threshold was set for all sample RSS to eliminate the impact of abnormal APs on FD, and a correction quantity for each RSS was provided by the distance between APs and sample positions to reduce the strong signal influence on FD. Furthermore, a priority weight was designed by RSS differences (RSSD) to further optimize FD’s capability to discriminate PD. Integrating the above policies, a new indoor fingerprint localization technique is redefined, referred to FD’s discrimination capability improvement WKNN (FDDC-WKNN), which is suitable for indoor scenes with a large number of APs that are not uniformly managed. Our simulation results show that the correlation and consistency between FD and PD are well improved, with strong correlation increasing from 0 to 76% and high consistency increasing from 26% to 99%, which confirms that the proposed policies can greatly enhance FD’s discrimination capabilities to PD, and we also found that abnormal APs can cause significant impact on FDs’ discrimination Capability. Further, by implementing the FDDC-WKNN algorithm in experiments, we obtained the optimal K value in both the simulation scene and real library scene, under which the average localization errors have been reduced from 2.2732m to 1.2183m and from 3.4295m to 2.2068m, respectively. In addition, compared to not using the FDDC-WKNN, the cumulative distribution function (CDF) of the localization errors curve converged faster and the errors fluctuation is smaller, which demonstrate FDDC-WKNN having stronger robustness and more stable localization performance to the state of APs in indoor environments.
Generating non-verbal responses in virtual agent with use of LSTM network
Authors: Koren Leon , Stipancic Tomislav
Published: January 2024

This paper investigates nonverbal communication in human interactions, with a specific focus on facial expressions. Employing a Long Short-Term Memory (LSTM) architecture and a custom-ized facial expression framework, our approach aims to improve virtual agent interactions by incorporating subtle nonverbal cues. The paper contributes to the emerging field of facial expres-sion generation, addressing gaps in current research and presenting a novel framework within Unreal Engine 5. The model's architecture, trained on the CANDOR corpus, captures temporal dynamics, and refines hyperparameters for optimal performance. During testing, the trained model showed a cosine similarity of -0.95. This enables the algorithm to accurately respond to non-verbal cues and interact with humans in a way that is comparable to human-human interac-tion. Unlike other approaches in the field of facial expression generation, the presented method is more comprehensive and enables the integration of a multi-modal approach for generating facial expressions. Future work involves integrating blendshape generation, real-world testing, and the inclusion of additional modalities to create a comprehensive framework for seamless hu-man-agent interactions beyond facial expressions.
STensoRRF:Tensorial able Relighting Radiance Field for Single-Tensor Scene Representation
Authors: Chen Xinlei , Zheng JunHong , He Lili
Published: January 2024

Reconstructing a 3D model of a scene from a set of multiple views poses a significant challenge in the field of computer vision. The advent of NeRF has marked a major breakthrough in this domain. However, there is a need to extend the capabilities of the NeRF model to enable editing tasks such as relighting and deformation, as well as to enhance its training efficiency. Neural reflectance fields introduce the concept of the reflectance equation into the NeRF framework to achieve relighting of the NeRF model. We leverage the TensoRF approach, which incorporates tensor decomposition and employs multiple tensors to store features, to expedite the training process of the NeRF model. Our novel method, called StensorR, combines the reflectance equation and tensor decomposition within the radiation field model framework. Differing from previous approaches, we employ a single tensor to store scene features and render the surface color of our scene using a simplified reflectance equation. This approach accelerates model convergence and enables relighting of the NeRF model. Experimental results demonstrate that our method achieves a 50% faster convergence rate compared to existing relighting radiation field models, while successfully enabling relighting and improving the quality of synthesized images from new viewpoints.
Clinicopathological Assessment of Thyroid Cancer Patients Re-ferred to Imam Khomeini Hospital of Sari from Early March 2014 to Late March 2021
Authors: Zaboli Ehsan , Ghaffari hamedani Seyed Mohammad Mahdi , Movahedirad , Seyedeh Marziye , Naghshvar Farshad , Ebrahimi Pouria , Ebrahimi Safieh , Babaeian Mahasti , Rezaei Saman , Hedayatizadeh Omran Akbar , Alizadeh Navaei Reza
Published: January 2024

Among endocrine cancers, thyroid carcinoma is the most prevalent type of cancer. It's prevalence has been increased throughout the world during the last decades, which shows great regional variations. Considering the increasing prevalence and occurrence of thyroid cancer cases, in this study we: Among endocrine cancers, thyroid carcinoma is the most prevalent type of cancer. It's prevalence has been increased throughout the world during the last decades, which shows great regional variations. Considering the increasing prevalence and occurrence of thyroid cancer cases, in this study we decided to evaluate the clinical and pathological charactristics of this endocrine system cancer in the population of thyroid cancer patients reffered to imam Khomeini Hospital in Sari between March 2014 and March 2021. decided to evaluate the clinical and pathological charactristics of this endocrine system cancer in the population of thyroid cancer patients reffered to imam Khomeini Hospital in Sari between March 2014 and March 2021.
Engineered Chimera Protein Constructs to Facilitate the Production of Heterologous Transmembrane Proteins in E. coli
Authors: Ogunbowale Adeyemi , Georgieva Elka R.
Published: January 2024

To delve into the structure-function relationship of transmembrane proteins (TMPs), robust protocols are needed to produce them in a pure, stable, and functional state. Among all hosts that express heterologous TMPs, E. coli has the lowest cost and fastest turnover. However, many of the expressed in E. coli TMPs are misfolded. Several strategies have been developed to either direct the foreign TMPs to E. coli’s membrane or retain them in a cytosolic soluble form to overcome this deficiency. Here, we summarize protein engineering methods to produce chimera constructs of the desired TMPs fused to either signal peptide or precursor maltose binding protein (pMBP) to direct the entire construct to the periplasm, therefore depositing the fused TMP in the plasma membrane. We further describe strategies to produce TMPs in soluble form by utilizing N-terminally fused MBP without signal peptide. Depending on its N- or C-terminus location, a fusion to apolipoprotein A-I can either direct the TMP to the membrane or shield the hydrophobic regions of the TMP, maintaining the soluble form. Strategies to produce G-protein coupled receptors, TMPs of Mycobacterium tuberculosis, HIV-1 Vpu, and other TMPs are discussed. This knowledge could increase the scope of TMPs’ expression in E. coli.
Solar Photovoltaic Cooker or Heater With No Electronics or Battery
Authors: Lecuona-Neumann Antonio , Nogueira-Goriba José I. , Famiglietti Antonio , Rodríguez-Hidalgo MariadelCarmen , Boubour Jean
Published: January 2024

he paper offers an innovative cooking utensil design for remote, isolated, and even peri-urban communities at a low price, with high reliability and simple construction. It can alleviate energy poverty and improve food security. This utensil uses only local solar energy directly and allows comfortable indoor cooking. This paper provides the design principles of a solar cooker/frying pan or generic heater, based on a PV panel or a plurality of them, which are directly connected to a plurality of Positive Thermal Coefficient (PTC) resistors to match the power. PTCs are nowadays produced in massive quantities and are widely available at low cost. The proposed device does not require an electronic controller or a battery for its operation. The aim is for family use, although the design can be easily scaled to a larger size or power, maintaining its simplicity. Electric heating inside or attached to the cooking pot, plus the temperature self-limiting effect of PTCs, allows for thermally insulating the cooking pot from its outside using ordinary materials. Insulation en-hances energy efficiency during cooking and keeps cooked food warm for a long time. Clean development would receive a significant impulse with its application. A simple mathematical model describes its functioning and states guidelines for adequate design. The results indicate a successful proof of concept and high efficiency both for water and oil as representatives of cooking.
Impact of COVID-19 Pandemic on Cardiovascular Healthcare in Croatia: A Comprehensive Nationwide Survey
Authors: Lukenda Josip , Borovac Josip Andelo
Published: January 2024

The impact of COVID-19 pandemic on the cardiovascular healthcare services in Croatia has not been systematically examined. In this study, we compared utilization and provision of cardiovascular services in Croatia during the pre-pandemic period (2017 to end of 2019) and pandemic period (2020 to end of 2021) by using large nationwide data from the Croatian Health Insurance Fund, an institution covering 95% of all insurance claims in Croatia. We report that the use of advanced heart failure treatment modalities increased while the number of coronary angiographies decreased while the number of performed percutaneous coronary interventions remained similar, even increasing in the setting of acute myocardial infarction, comparing pandemic to pre-pandemic period. Similarly, the number of transcatheter aortic valve implantations increased significantly during the pandemic era. There was a significant increase in laboratory diagnostic testing with troponin and natriuretic peptide assays during the pandemic period while the use of most cardiovascular services remained stable or only slightly decreased, compared to pre-pandemic period. These data suggest that Croatian cardiovascular healthcare services during COVID-19 pandemic showed resilience and managed to maintain or even increase the number of various diagnostic and interventional procedures despite the widespread societal and logistical challenges encountered during pandemic.
SSE-YOLO: Efficient UAV Target Detection With Less Parameters and High Accuracy
Authors: Lu Yong , Sun Minghao
Published: January 2024

Despite UAV multi-target detection exhibits considerable developmental potential worldwide, it suffers distinct challenges compared with traditional tasks in this field. These challenges include insufficient feature extraction capabilities for small targets, limited capabilities for multi-dimensional feature fusion, as well as constraints on hardware computation parameters. Especially in mission scenarios such as disaster detection, these challenges will be further amplified. Consequently, this paper introduces SSE-YOLO, an innovative YOLO framework algorithm specially designed to address these challenges. To enhance the model's feature extraction capability, we employ the SPDConv module to replace the original Conv in the backbone section, utilizing depth-separable convolution instead of traditional convolution pooling. Concurrently, we eliminate the SPPF module at the bottom and address a new Separate Kernel Attention Pyramid Pooling (SKAPP) module, substantially enhancing the feature fusion capability at the model's core. Moreover, to address the challenge of multi-dimensional feature fusion, we replace the Concat module of the neck and head with E-BiFPN, transmitting feature information from the backbone to the lower network through four CBS blocks, which effectively resolves the issue of lost contextual information in the model. Meanwhile, SSE-YOLO undergoes ablation experiments on the VisDrone2019 dataset to evaluate its effectiveness against alternative methods, and experimental results illustrate the model's exceptional precision in detecting UAV targets. In comparison to models with comparable experimental accuracy, SSE-YOLO requires remarkably fewer parameters. On the VisDrone2019-DET-test-dev dataset, SSE-YOLO enhances mAP by 17.3%, with a 42.5% reduction in the parameter amounts. Therefore, the proposed method effectively tackles the challenge of reconciling low parameters and high accuracy, presenting a novel pathway for deep learning-based UAV multi-target detection.
Impact of Patient Blood Management on Red Blood Cell Utilization in an Urban Community Teaching Hospital: A Seven-Year Retrospective Study
Authors: Wu Ding Wen , Friedman Mark T , Lombardi Daniel , Hwang Richard , Sender Joel , Cobaj Valdet , Niazi Masooma , Li Yanhua , Karpinos Robert
Published: January 2024

The study aimed to showcase how implementing a patient blood management (PBM) program effectively cut unnecessary red blood cell (RBC) transfusions in a New York City urban community teaching hospital. Analyzing seven years from 2013 to 2019, a retrospective review of RBC transfusions was conducted. Following PBM introduction, considerable improvements were observed annually. These included a drop in mean pretransfusion hemoglobin levels from 7.26g/dL (2013) to 6.58g/dL (2019), a 34% reduction in yearly RBC unit transfusions, and fewer units given to patients with pre-Hgb levels ≥7g/dL (1210 units in 2013 to 310 units in 2019). Furthermore, the study noted a decline in two-unit RBC orders when Hgb levels were ≥7g/dL from 65 orders in 2013 to merely 3 in 2019. The estimated total cost-savings attributed to the six-year PBM program duration after full implementation in 2014 amounted to $2.1 million US dollars. Overall, PBM implementation significantly decreased RBC transfusions and enhanced transfusion practices. The findings emphasize that successful PBM strategies don't always necessitate extensive resources or increased budgets but instead rely on the application of intuitive methods, as evidenced by this study.
Addressing Thalassaemia Management from a Patients’ Perspective: an International Collaborative Assessment
Authors: Economidou Eleftheria C. , Angastiniotis Michael , Avraam Demetris , Soteriades Elpidoforos S. , Eleftheriou Androulla
Published: January 2024

Background and objectives: Effective management for chronic diseases, hereditary and rare diseases and Thalassaemia in particular constitutes an important indicator for the quality of healthcare systems. We aimed at assessing healthcare services in different countries by using publicly available health indicators and by surveying Thalassaemia patients and their caregivers. Materials and Methods: We reviewed official worldwide databases from the WHO, World Bank, and scientific resources and also used a structured patient tailored self-completed questionnaire to survey Thalassaemia patients and their caregivers in 2023. Results: A total of 2,082 participants were surveyed (mean age 27 years, males 42%). About 1 in 4 respondents had less than high school education, while 24% had a bachelor degree. About a third of respondents were married and had either full- or part-time employment. The vast majority (~80%) had initiated transfusion therapy between 1 – 4 years of age. Only 42% reported no delays in receiving blood transfusion, while 47% reported occasional delays and 8% serious delays. About half of patients reported being very satisfied (11%) or satisfied (38%) with the quality of provided services, while 1 in 3 patients reported being unsatisfied or very unsatisfied, and their access to treatment was difficult or very difficult due to traveling expenses and high cost of treatment. Conclusion: Important improvements in the care of Thalassaemia patients have been documented during the past decades. Nevertheless, our recent survey reveals many unmet needs where additional focus is required through national healthcare systems in order to address them effectively and achieve satisfactory patient outcomes.
Usage Patterns of Traditional Chinese Medicine for Patients With Bipolar Disorder: A Population-Based Study in Taiwan
Authors: Chen Shu-ping , Yang Su-Tso , Hu Kai-Chieh , Satyanarayanan Senthil Kumaran , Su Kuan-Pin
Published: January 2024

Background: Patients with bipolar disorder (BD) receive traditional Chinese Medicine (TCM) for unmet clinical needs with psychotropic medications. However, the clinical characteristics of practices and outcomes of TCM in BD are not fully understood. This cohort study investigated the clinical characteristics, principal diagnoses, TCM interventions, and TCM prescriptions in patients with BD. Methods: 12,113 patients with BD were withdrawn from Taiwan's longitudinal health insurance database 2000 (LHID 2000) between 1996 and 2013. Chi-squared test for categorical variables and independent t-test for continuous variables. A p-value less than 0.05 indicated significance. Results: One-thousand and three hundred nineteen patients who visited TCM clinics after the diagnosis of BD were in the TCM group, while those who never visited TCM were in the non-TCM group (N= 1,053). Compared to the non-TCM group, patients in the TCM group had younger average age, a higher percentage of female individuals, more comorbidities of anxiety and alcohol use disorders, and higher mood stabilizer usage rates. The TCM group exhibited pain-related indications, including joint pain, myalgia, myositis, headache, and sleep disturbances. Corydalis yanhusuo and Shu-Jing-Huo-Xue-Tang were the most useful single herb and herbal formulas. Conclusions: Physicians need to be aware of the use of TCM in Patients with BD.
Research on Distributed Photovoltaic Grid-Connected Fault Diagnosis Methods: A Review
Authors: Wan Qingzhu , Zhang Yu
Published: January 2024

Power grid fault diagnosis technology has been widely used at home and abroad. With the access of distributed power sources and diversified loads, the distribution network has changed from a passive network to an active network, and the current has changed from "one-way" to "two-way". The structure of distribution network, equipment environment and operating conditions are becoming more and more complex, and the fault diagnosis and localization of active distribution network is becoming more and more difficult. With the rapid development of artificial intelligence, power grid fault diagnosis based on intelligence is unprecedented. This paper introduces the research status of distributed photovoltaic grid-connected fault diagnosis technology, and expounds the history of fault diagnosis technology, which mainly includes expert system, artificial neural network, Bayesian network, fuzzy set theory, rough set theory, Petri net analytical model and multi-source information fusion, etc. The applicability and characteristics of these diagnoses are described, and the existing defects and the overall direction of improvement are briefly described Finally, the key technical problems and future directions in the field of power system fault diagnosis are pointed out by combining theory with practice, so as to promote the further development of this field.
Intracellular “In Silico Microscopes” – Fully 3D Spatio-Temporal Virus Replication Model Simulations
Authors: Knodel Markus M. , Nägel Arne , Herrmann Eva , Wittum Gabriel
Published: January 2024

Despite being small and simple structured in comparison to their victims, virus particles have the potential to harm severly and even kill highly developed species such as humans. To face upcoming virus pandemics, detailed quantitative biophysical understanding of intracellular virus replication mechanisms is inevitable. Unveiling the relationship of form and function might allow to determine putative attack points relevant for the systematic development of direct antiviral agents (DAA) and potent vaccines. Biophysical investigations of spatio-temporal dynamics of intracellular virus replication so far are rare. We are developing a framework to allow for fully spatio-temporal resolved virus replication dynamics simulations based on partial differential equations models (PDE) and evaluated with advanced numerical mathematical methods on leading supercomputers. This study presents an advanced highly nonlinear model of the genome replication cycle of a specific RNA virus, the Hepatitis C virus (HCV). The diffusion-reaction model mimics the interplay of the major components of the viral RNA (vRNA) cycle, namely non structural viral proteins (NSP), vRNA and a generic host factor. Technically, we couple surface PDEs (sufPDEs) on the 3D embedded 2D Endoplasmatic Reticulum (ER) manifold with PDEs in the 3D membranous web (MW) and cytosol volume. (The MWs are the replication factories growing on the ER induced by NSPs.) The sufPDE/PDE model is evaluated at realistic reconstructed cell geometries which are based on experimental data. The simulations couple the effects of NSPs which are restricted to the ER surface with effects appearing in the volume. The volume effects include the host factor supply from the cytosol and the MW dynamics. Special emphasis is put to the exchange of components between ER surface, MWs and cytosol volume. As the vRNA spatial properties are not fully understood so far in experiment, the model allows for vRNA both restricted to the ER and moving in the cytosol. The visualization of the simulation resembles a look into some sort of fully 3D resolved “in silico microscopes” to mirror and complement in vitro / in vivo experiments for the intracellular vRNA cycle dynamics. The output data are quantitatively consistent with experimental data and provoke advanced experimental studies to validate the model.
In memoriam: Professor Natalya V. Perova (12.08.1939 — 20.12.2023)
Authors: Editorial Article
Published: January 2024

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A mathematical model for assessing the contribution of viral hepatitis to the formation of infectious penitentiary syndrome.
Authors:   Pskov State University, Averyanova E.L. , Mikhaylova Yu.V. ,   Russian Research Institute of Health, Ponomarev S.B. ,   Research Institute of the Federal Penitentiary Service of Russia, Sterlikov S.A. ,   Research Institute of Health, Popova N.M. ,   Izhevsk State Medical Academy, Mikhaylov A.Yu. ,   Research Institute of Health, Pankova Ya.Yu. ,   Research Institute of Health
Published: January 2024

P u r p o s e : to study the role of viral hepatitis in the development and course of comorbid infection (disease caused by HIV, tuberculosis and parenteral viral hepatitis) in persons serving the penalty of deprivation of liberty. M e t h o d s . The indicators reflecting the epidemic situation of tuberculosis, HIV infection and parenteral viral hepatitis in institutions of the Russian penal system were analyzed. Correlation analysis and multiple regression analysis were conducted, followed by an analysis of the quality of the obtained regression models (calculation of the coefficient of determination). R e s u l t s . The following parameters have the maximum correlation between the predictors and the response function in this group of observations, with the subsequent exclusion of factors whose correlation with the variables involved in the calculations was higher than the correlation of these indicators with the response function: the incidence of hepatitis B per 100 thousand people (r = 0,86) [X1], the number of newly diagnosed hepatitis C patients in 2021 (r = 0,85) [X2], the proportion of newly diagnosed HIV-infected people in combination with tuberculosis and viral hepatitis (B, C, B+D), % (r = 0,85) [X3], the number of HIV patients receiving ART (r = 0,85) [X4], the incidence of tuberculosis in Pre-trial detention center (PTDC), per 100 thousand people (r=0,41) [X5], the number of newly arrested tuberculosis patients identified during the initial examination (r = 0,41) [X6]. The model was obtained: simulated mortality from HIV = –6,7 + 0,48 * X1 + 0,39 * X3 – 0,07 * X5 (R2 = 0,86). A similar model was obtained for the absolute values of the number of deaths; it involved the following parameters: the number of newly diagnosed patients with viral hepatitis B [X1], the number of newly diagnosed patients with viral hepatitis C [X2], the number of newly diagnosed HIV patients in combination with tuberculosis [X3], the number of patients burdened by premorbid background (injecting drug users) [X4]: The number of deaths from HIV= –0,36 + 0,06 * X1 + 0.02 * X2 + 0.36 * X3 + 0,03 * X4 (R2 = 0.91). C o n c l u s i o n . The association of HIV mortality rate with viral hepatitis and tuberculosis incidence is shown and estimated. HIV mortality can be considered as a function of the following factors: 1) the incidence of hepatitis B, 2) the proportion of first-time detected persons with HIV-tuberculosis-viral hepatitis coinfection, and 3) the incidence of tuberculosis in pre-trial detention centers.
Morbidity of adolescents and some aspects of the relevance of medical and professional consultation of adolescents aged 15–17 years.
Authors:   Federal State Budgetary Educational Institution of Higher Education «Orenburg State Medical University» of the Ministry of Health of the Russian Federation, Bulycheva E. V.
Published: January 2024

Currently, conducting medical and professional consultations and medical professional orientation remains relevant against the background of the current situation of high morbidity of adolescents, inadequate choice of the direction of vocational training and uncontrolled employment, which requires the development and implementation of effective methodological approaches to the organization of professional orientation, taking into account the modern requirements of the labor market. The aim of the study is to assess the health status of adolescents, the professional orientation of adolescents and the leading occupational health risk factors. Research methods. On the example of Orenburg, an analysis of the morbidity of adolescents aged 15–17 years according to official statistics was carried out; a characteristic of the safety of workplaces at industrial enterprises of the Orenburg region was given; an assessment of the professional preferences of adolescents according to the method of I. L. Solomin was carried out in conjunction with the performance indicators determined by the method of «Landolt Rings». The results of the study. It is shown that adolescents aged 15–17 years have higher morbidity rates compared to the adult population of the Orenburg region by 8–29.1%, while every second teenager has a disease for the first time. The leading nosological forms in the structure of morbidity of adolescents were diseases of the musculoskeletal system and connective tissue, diseases of the organ of vision and its accessory apparatus and diseases of the genitourinary system. Common inconsistencies with sanitary standards in the workplaces of industrial enterprises of the region were indicators of vibration, microclimate and illumination. Every third teenager had professional preferences in the field of «man-man», which actualizes the problems of professional orientation, taking into account psychophysiological features, which have significant differences depending on the inclination to a particular profession. Conclusion. Medical professional orientation and medical and professional consultation for adolescents are an important area of work in the structure of primary health care for the adolescent population, contributing to the prevention of the progression of pathologies as a result of the adverse effects of production factors, the prevention of disability and increased productivity.
Digital information support of patients in medical organizations.
Authors:   State Autonomous Healthcare Institution «Republican Medical Information and Analytical Center», Ganeev K. A.
Published: January 2024

Today, digital transformation in the communication of an organization with its customers is more a necessity than a trend. It has penetrated into all spheres of life of modern society, including medical. However, only a small proportion of medical organizations (MO) understand this and are ready to switch their organizational systems and processes of communicating with patients to «digital». Based on the low level of awareness about digital information support tools and the willingness to allocate the organization’s budget for this, it is advisable at the beginning to focus on optimizing those tools that the Ministry already has and can improve. Thus, an effectively implemented strategy of using digital communication tools will allow the Ministry of Health to attract the attention of potential patients and significantly reduce the cost of existing tools, as well as increasing the effect of it. T h e p u r p o s e o f t h e s t u d y : to study the use of modern digital technologies for patient information support and develop proposals for their implementation and improvement in medical organizations M e t h o d s . The study used a descriptive method, questionnaire, analysis, comparison. Based on the results of the survey, a SWOT analysis was compiled. R e s u l t s . A survey was conducted among 100 patients of two medical organizations, which showed that digital information support for patients is poorly developed. Attention should be paid to the development and improvement of existing tools such as the website, messengers, social networks and chatbots of medical organizations. C o n c l u s i o n s . The introduction by medical organizations of new and improvement of old tools for digital information support of patients has a positive effect on the exchange of information with them. However, there is a clear link between the patient’s age and his desire to use digital means of communication. Based on this, the heads of the Ministry of Health should regularly conduct research on the quantitative and qualitative composition of their patients and, based on them, develop the necessary tools for digital information support.
Main indicators of obstetric care in the region of Central Russia.
Authors:   N. A. Semashko National Research Institute of Public Health, Mingazova E. N. , Zhelezova P. V. ,   N. A. Semashko National Research Institute of Public Health, Khabriev R. U. ,   N. A. Semashko National Research Institute of Public Health
Published: January 2024

The article presents an analysis of the main indicators of obstetric care in the region of the Central Federal District – Kostroma Region. Despite the identified positive trends in the reproductive and demographic process in the Kostroma region, a number of significant problems remain (exceeding the Russian average for the number of complications in labor, termination of pregnancy, infant mortality, etc.) that require management decisions in improving the obstetric care system and ensuring the proper level of medical care mother and child. This direction of improving the activities of the healthcare system of the Kostroma region is of paramount importance in conditions of reduced population reproduction
Incidence of acute coronary syndrome in the Russian Federation and in the Republic of Bashkortostan.
Authors:   LLC «Oktyabrsky Vascular Center», Republic of Bashkortostan, Topalyan K. V. , Kalinskaya A. A. ,   FGBI “National Research Institute of Public Health named after N. A. Semashko»
Published: January 2024

Purpose of the study. Based on an analysis of the medical and demographic situation and the incidence of acute coronary syndrome in the Russian Federation, in the federal districts and constituent entities of the Russian Federation, as well as in the pilot territory of the Republic of Bashkortostan, proposals are given for the development of management decisions at the regional and federal levels. Materials and methods: statistical, analytical. We used statistical materials of the Federal State Statistics Service (2014–2021), statistical materials: M., TsNIIOIZ of the Ministry of Health of the Russian Federation (2023) and the Republic of Bashkortostan MIAC, Ufa (2022). Results. The leading cause of mortality in the Republic of Belarus, as well as in the Russian Federation as a whole, is diseases of the circulatory system (CVD). In 2022, the mortality rate of the population from CVD in the Republic of Belarus was 459,5 per 100 thousand population, in the Russian Federation the figure was higher – 560,8‰oo. Fluctuations in indicators in the constituent entities of the Russian Federation are 7,6 times. The primary morbidity rate of the adult population in the Republic of Bashkortostan was BSK (2022) 4948,6‰oo. Acute coronary syndrome (ACS) is a group of clinical symptoms or signs suggestive of acute myocardial infarction (MI) or unstable angina (UA). The primary incidence rate of the adult population of the Republic of Belarus with unstable angina pectoris was (2022) 113,8‰oo, acute myocardial infarction – 97,7‰oo, in the Russian Federation the figures are higher – 106,7 and 140,8‰oo, respectively. The difference in the incidence of myocardial infarction among the adult population in the constituent entities of the Russian Federation is 9,3 times; the difference in unstable angina is huge – 54 times, which to a certain extent indicates the ambiguity of the coding of unstable angina. The study indicates the need for an in-depth analysis of the incidence of acute coronary syndrome in the constituent entities of the Russian Federation. Conclusions. It is necessary to develop management decisions, including improving the accessibility and quality of cardiac care to thepopulation, including patients with acute coronary syndrome, at the regional and federal levels.
Technology for data import to Interin PROMIS Alpha PG.
Authors:   Federal Ailamazyan А. К. Program Systems Institute of Russian Academy of Sciences, Belyshev D. V.
Published: January 2024

The key step in launching an information system is the legacy data transfer. There are many tools and techniques to help us solve this problem in terms of special features of software products and projects. The article studies the methodology and means of migrating data when implementing the Interin PROMIS Alpha PG medical information system.
Cash Holding em Governos Locais Brasileiros
Authors: Cabello Otavio Gomes , Rocha de Azevedo Ricardo , Dario Capitani Daniel Henrique
Published: January 2024

Objetivo da pesquisa - A pesquisa teve como objetivo examinar os determinantes de retenção de caixa dos governos locais brasileiros.

Enquadramento teórico – Este trabalho se apoia na teoria de finanças da preferência pela liquidez.

Metodologia – trata-se de pesquisa econométrica desenvolvida com dados econômico-financeiros dos anos de 2017 a 2021 dos municípios brasileiros, utilizando o modelo de regressão linear com dados em painel, efeitos fixos.

Resultados - Os resultados apresentaram que as variações de despesa com pessoal e encargos, imprecisão da previsão das receitas correntes, dependência de receitas e população configuram como determinantes de cash holding em governos locais brasileiros.

Originalidade – Os resultados preenchem uma lacuna existente na literatura de finanças públicas sobre quais seriam os determinantes de retenção de caixa dos governos locais brasileiros.

Contribuições teóricas e práticas - Os resultados contribuem para uma discussão sobre políticas de retenção de caixa nos governos de países emergentes e contribuem com a literatura que discute o efeito flypaper, dado que o efeito pode ocorrer em exercícios seguintes ao ingresso da receita, não tratado pela literatura. Por fim, a pesquisa apresenta a imprecisão da previsão das receitas correntes como um novo determinante de cash holding nos governos locais.
Kesiapan dan Hambatan Guru dalam Mengimplementasikan Kurikulum Merdeka di Sekolah Dasar
Authors: Ardhani Kusuma , Tisngati Urip , Sugiyono
Published: January 2024

Penelitian ini bertujuan untuk mendeskripsikan: (1) implementasi kurikulum merdeka, (2) kesiapan guru dalam mengimplementasikan kurikulum merdeka, (3) hambatan guru dalam mengimplementasikan kurikulum merdeka di SD Negeri Ponggok. Penelitian ini menggunakan metode penelitian kualitatif dengan menggunakan pendekatan deskriptif. Subjek dalam penelitian ini adalah kepala sekolah dan guru SD Negeri Ponggok. Teknik pengumpulan data meliputi observasi, wawancara, dan dokumentasi. Analisis data menggunakan teknik deskriptif kualitatif. Hasil yang diperoleh dalam penelitian ini yaitu: 1) Implementasi kurikulum merdeka dalam pembelajaran dikategorikan sangat baik, yang mencakup persiapan pembelajaran, pelaksanaan pembelajaran, dan penilaian pembelajaran; 2) Kesiapan guru SD Negeri Ponggok dalam implementasi kurikulum merdeka dikategorikan sangat baik pada persiapan, pelaksanaan, hingga penilaian pembelajaran dan dari tiga karakteristik kurikulum merdeka yang ada pada lembar observasi dua diantaranya terpenuhi; 3) Hambatan yang dialami oleh guru SD Negeri Ponggok dalam mengimplementasikan kurikulum merdeka, yaitu sulitnya mengubah metode mengajar yang lama dan penerapan pembelajaran berdiferensiasi yang belum maksimal.
Media Buku Saku Bermuatan Keunggulan Seni Tari Lokal Kabupaten Pacitan untuk Meningkatkan Apresiasi Budaya pada Siswa SD
Authors: Saputra Muhammad Aji , Ardhyantama Vit , Tisngati Urip
Published: January 2024

Penelitian ini bertujuan untuk mendeskirpisikan: (1) prosedur pengembangan media buku saku; (2) kelayakan pengembangan media buku saku; (3) hasil pengembangan media buku saku untuk meningkatkan apresiasi budaya siswa. Jenis penelitian ini research and development (R&D) dengan model pengembangan 4D. Teknik pengumpulan data dengan menggunakan observasi, wawancara, angket, dan dokumentasi. Analisis data menggunkan teknik tingkat kevalidan produk dan analisis data uji coba. Hasil penelitian menunjukan bahwa: (1)  media buku saku untuk meningkatkan apresiasi budaya siswa telah dikembangkan dengan model pengembangan  4D dengan uji coba dan validasi ahli; (2) Media buku saku layak berdasarkan penilaian ahli materi dengan rata-rata sekor 4 “Valid”, penilaian ahli media dengan rata-rata skor 4,11“Vaild”, penilaian ahli bahasa dengan rata-rata skor 3 ‘‘ Cukup Valid’’, dan penilaian siswa dalam uji kelompok kecil dengan rata-rata 4 “Valid” (3) media dinyatakan efektif berdasarkan pencampaian aperesiasi budaya siswa  yang mencapai nilai sebesar 100%.
State-dependent auditory-reward brain network connectivity predicts degree of pleasure to music
Authors: Mori Kazuma , Zatorre Robert
Published: January 2024

Music can evoke pleasurable and rewarding experiences. Past studies that examined task-related brain activity revealed individual differences in musical reward sensitivity traits, and linked them to interactions between the auditory and reward systems. However, state-dependent fluctuations in spontaneous neural activity in relation to music-driven rewarding experiences have not been studied. Here, we used functional MRI (N=49) to examine whether the coupling of auditory-reward networks during a silent period immediately before music listening can predict the degree of musical rewarding experience. We used machine learning models and showed that the functional connectivity between auditory and reward networks, but not others, could robustly predict subjective, physiological, and neurobiological aspects of the strong musical reward of chills. Specifically, the right auditory cortex-striatum/orbitofrontal connections predicted the reported duration of chills and the activation level of NAcc and insula, whereas the auditory-amygdala connection was associated with psychophysiological arousal. Furthermore, the predictive model derived from the first sample of individuals was generalized in an independent dataset using different music samples. The current study reveals the critical role of sensory-reward connectivity in pre-task brain state in modulating subsequent rewarding experience.