bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the cytotoxic effects and apoptosis inducing of Cuscuta epithymum extract on esophageal squamous cell carcinoma
Authors: Hashemi M. , Panahi A. , Nosrati R. , Oranj G. D. , Jafari-Shakib R.
Published: September 2024

Background. Esophageal cancer is the eighth most common cancer in the world. The antitumor effects of medicinal plants have been shown as a therapeutic strategy to treat esophageal cancer. This study aimed to evaluate in vitro effects of Cuscuta epithymum extract on the survival and apoptosis of esophageal cancer cell line. Material and Methods. Here, the hydroalcoholic Soxhlet extract of C. epithymum plant was prepared. The cell viability of esophageal cancer cell line KYSE-30 was evaluated by MTT assay after 24 h treatment with concentrations of 50, 100, 200, 400, 600, 800 and 1000 μg/ml of the extract. Then, the apoptotic effect of extract was evaluated by flow cytometry using Propidium Iodide (PI) staining and sub-G1 peak analysis, and Annexin V-FITC/PI staining in cells treated with concentrations of 125, 250, 500 and 750 μg/ml as well as morphological change of healthy cells to apoptotic and necrotic form. Results. The hydroalcoholic extract of C. epithymum decreases the viability of KYSE-30 cells in a dose-dependent manner with an IC50 of 646 µg/ ml at 24 h. A significant increase was observed in the percentage of sub-G1 phase in cells treated with 500, 750, and 1000 μg/ml of C. epithymum extract for 24 h compared to the control group (p<0.01 and p<0.001). The results also showed a significantly enhanced the percentage of primary and secondary apoptotic cells compared to untreated cells. At concentrations of 250, 500, and 750 µg/ml, approximately 17, 33 and 45 % of cells was apoptotic. The apoptotic and necrotic cells morphology after treatment with 250 and 500 µg/ml of the extract was also confirmed by fluorescence microscopy. Conclusion. The findings showed the apoptotic effect of the hydroalcoholic extract of C. epithymum on KYSE-30 cells in vitro. The effect of this extract on the genes involved in apoptosis as well as the mechanism of action of this extract are recommended.
OTO-IVM is a method of fertility preservation for patients with ovarian tumors
Authors: Lavrinovich O. E. , Tatischeva Yu. A. , Berlev I. V. , Yakovleva M. G. , Karitski A. P. , Kalugina A. S.
Published: September 2024

Introduction. An increasing number of patients of reproductive age get cancer and are highly interested in preserving fertility. Survival rates for cancer patients are improving. Methods of reproductive technologies are being improved to preserve the ability to bear children. Rehabilitation aimed to ensure a satisfactory quality of life takes on a new meaning, and with the development of new technologies, the level of possible assistance also changes. Today, rehabilitation measures for cancer patients of reproductive age should undoubtedly include all possible ways to preserve and restore fertility. Aim: preservation of fertility in patients with ovarian tumors. Material and Methods. After ovariectomy, the ovaries were transported to the embryology laboratory, where oocyte-cumulus complexes were extracted and subsequently matured using the OTO-IVM (ovarian tissue oocyte in vitro maturation) method. The resulting mature oocytes (Metaphase II) were cryopreserved by vitrification or, if a partner was available, fertilized by ICSI (intracytoplasmic sperm injection), the embryos were cultured to the blastocyst stage and also cryopreserved by vitrification. Cryopreserved oocytes and embryos can be used by patients after cancer treatment in assisted reproductive technology programs. Results. A total of 218 OCCs were recovered, 29.8 % were degraded oocytes (n=65). The proportion of OCC suitable for ripening was 153 (70.2 %). After 36 or 48 hours, 65 oocytes matured in 13 patients, which amounted to 42.5 % of oocytes without signs of degradation. In 11 patients the OCC was removed from the tumor-affected ovary. 149 oocytes were obtained, of which 50 (33.6 %) were oocytes with signs of degradation. The remaining 99 (66.4 %) of OCCs had satisfactory quality; after maturation, the Metaphase II stage reached in 49 (49.5 %) of oocytes. As a result, biological material was cryopreserved in 13 of 15 patients: 5 embryos and 60 oocytes.
Adiabatic gauge potential and integrability breaking with free fermions
Authors: Pozsgay Balázs , Sharipov Rustem , Tiutiakina Anastasiia , Vona István
Published: September 2024

We revisit the problem of integrability breaking in free fermionic quantum spin chains. We investigate the so-called adiabatic gauge potential (AGP), which was recently proposed as an accurate probe of quantum chaos. We also study the so-called weak integrability breaking, which occurs if the dynamical effects of the perturbation do not appear at leading order in the perturbing parameter. A recent statement in the literature claimed that integrability breaking should generally lead to an exponential growth of the AGP norm with respect to the volume. However, afterwards it was found that weak integrability breaking is a counter-example, leading to a cross-over between polynomial and exponential growth. Here we show that in free fermionic systems the AGP norm always grows polynomially, if the perturbation is local with respect to the fermions, even if the perturbation strongly breaks integrability. As a by-product of our computations we also find, that in free fermionic spin chains there are operators which weakly break integrability, but which are not associated with known long range deformations.
Does Terrorism Still Spread Fear to ASEAN’s Financial Market?
Authors: Johan Suwinto
Published: September 2024

The research aimed to examine the financial markets’ responses to terrorist attacks in Southeast Asia. Market reactions were a reflection of public sentiment. The market reaction was calculated using the stock index indicator and the currency exchange rate of the country relative to the US Dollar. The research employed a paired test to compare the period prior to and following the terrorist attack. The research used Wilcoxon Test to examine 38 terrorist attacks across four Southeast Asian nations: Indonesia, Thailand, Philippines, and Malaysia. The research concludes that the stock index exhibits both normal and abnormal returns between pre-incident and post-incident periods. Post-incident returns are higher than pre-incident returns. Stockholders are not required to sell their existing holdings in response to a terrorist attack. Between pre-incident and post-incident investors who do not invest in the capital or money markets, the foreign exchange market does not exhibit significant changes. Investors can profit by purchasing stock or foreign currency on the day of the incident or one day afterwards and selling it three days later.
SUSTENTABILIDADE E ODS NAS PÁGINAS: UMA ANÁLISE DE CONTEÚDO DOS LIVROS DIDÁTICOS DO PNLD 2021 NO CONTEXTO DA QUÍMICA
Authors: P. Silva Iasmyn , M. L. Ferreira Kleber , S. Pinto Paula , T. da Cunha Tamyris
Published: September 2024

SUSTAINABILITY AND SDGS ON THE PAGES: A CONTENT ANALYSIS OF PNLD 2021 TEXTBOOKS IN THE CONTEXT OF CHEMISTRY. Sustainability and Sustainable Development Goals (SDGs) have gained prominence in contemporary discourse, driven by the urgency of addressing climate change and demand for transformative actions for planet preservation. Recognized by global entities such as the United Nations and the Brazilian Chemical Society, Basic Education is crucial for instigating societal change. In the context of the diverse Brazilian classrooms, textbooks stand out as a common resource for educators and students, so how would the terms sustainability and SDGs be used in textbooks? Are these terms covered in the context of chemistry? This article utilizes Bardin’s content analysis to approach the terms sustainability and SDGs in National Textbook Program (PNLD) materials for Natural Sciences area, focusing on chemistry. The analysis of PNLD collections revealed that “sustainability” is broadly defined, but lacks specific contextualization within chemistry. SDGs, on the other hand, are mentioned cursorily, serving more as historical markers than engaging in meaningful discourse. Consequently, this article emphasizes the need for greater involvement of the chemistry community in shaping decisions related to textbooks. It calls for a concerted effort by chemistry Educators and Society to actively contribute to educational material discussions, fostering a more comprehensive integration of sustainability and SDGs within Chemistry Education.
Pancasilais Sufi: Kiai Asrori as a Portrait of Nationalist and Moderate Figure in Disruption Era
Authors: Shobah Muhammad Nurush , Setiyani Wiwik , Yaqin Ainul , Hakim Lukman
Published: September 2024

The relationship between Islam and the state is still debatable in Indonesia. Pancasila, as the foundation of the state, is also often contested, even though it was formulated by the Indonesian founding fathers through a very serious academic debate. This study will examine the role of K.H. Ahmad Asrori Al-Ishaqi (hereafter Kiai Asrori) Kedinding Surabaya as a Pancasilaist Sufi. This is qualitative-based research, where the data were collected from Kiai Asrori's works and his lectures uploaded on YouTube, observations, and direct and indirect interviews. The findings show that Kiai Asrori is a Sufi who is able to demonstrate that there are similarities between the teachings of Sufism and nationalism, especially with Pancasila. Both even have a symbiotic association. Kiai Asrori is an ulama and a Sufi who upholds the values of nationalism and democracy, which are reflected in the Majelis Lima Pilar (Five Pillars Assembly) he established. This assembly was built on two foundations, namely the practice and teachings of Sufism and nationalism and democratic values.Contribution: This study will provide new insights into Sufi practices and teachings that align with Pancasila values reflected in the figure of Kiai Asrori.
Digital Media Impact on Sufi Practices: Analyzing Ijāza Wirid Dhikr
Authors: Rizki Ahmad , Rusdi Hasan
Published: September 2024

This article discusses the impact of digital media on Sufi practices, specifically in the context of conducting ijāza (authorization) for wird dhikr rituals through digital platforms. Traditionally, Sufi practices such as the ijāza involve direct teaching from teacher to student. However, with the rapid development of digital media, the ijāza process has undergone significant changes. This study adopts an eclectic approach, which combines digital ethnography to study online participant engagement and a comprehensive literature review to track and measure the transformation of ijāza through digital media. Data were gathered from various sources, including books, scholarly journals, and relevant digital content related to the research topic. The findings show that the evolution of digital media has transformed the implementation of ijāza for wird dhikr from direct (traditional) to indirect transmission through online media, and it is considered valid. Yet, ijāza is not merely dealing with the process of authorization but also the transmission of blessings and spiritual knowledge from the teacher to the student, which needs close engagement and relationships that can only be achieved with direct interaction.Contribution: This article provides an understanding of the impact and validity of ijāza conducted through digital media compared to traditional methods yet considered valid.
Mastering by Students of the Secondary Vocational Education System of the Main Section “Information Modeling” of the Discipline Program “Informatics” on the Basis of the Mental Approach
Authors: Timofeeva K. E.
Published: September 2024

Purpose. The purpose of the article is to substantiate the use of the mental approach in the system of secondary vocational education when students master the main section “Information Modeling” of the discipline “Informatics”.Research methodology. The idea of the study is related to the implementation of the mental approach in the system of secondary vocational education when students master one of the main sections of the sample work program of the general educational discipline “Informatics”, compiled by the authors of the Federal State Budgetary Educational Institution of Additional Professional Education “Institute for the Development of Professional Education”. The use of the mental approach in studying the section devoted to information modeling is implemented on the basis of its two stages: at the first stage, connections are formed between the areas of the sensory zone and their model representations, at the second stage of training, the acquired intuitive experience is systematized using the concepts and terms of the subject area “Informatics”, as well as the section “Information Modeling”. To implement the mental approach, mental electronic textbooks are used, which make it possible to present and interpret the educational material of the section in the form of three levels: figurative-visual, model and theoretical-conceptual form. To implement the form of electronic textbooks, the development of N. Pak and N. Amangazy ugly was taken as a basis, demonstrating the transformation of educational resources in favor of transformer textbooks, adapted to the needs of the secondary vocational education system.Results. Based on the application of the mental approach in the system of secondary vocational education, the content and structure of the transformer textbook for the section “Information Modeling” of the discipline “Informatics” were developed, mental schemes of the module were compiled, an approximate content of question blocks for mastering the program module was proposed.Conclusions. The application of the mental approach to the system of secondary vocational education in the mastering by students of the main section of the discipline “Informatics” “Information Modeling” contributes to increased interactivity in lectures and practical classes, the organization of control and self-control of students’ knowledge.
Prováveis híbridos de saíra-ferrugem, Hemithraupis ruficapilla, e saíra-de-papo-preto, Hemithraupis guira, no estado de Santa Catarina, Sul do Brasil
Authors: Douglas Meyer
Published: September 2024

Por meio de observações ocasionais entre os anos de 2020 e 2024, foram registrados nove prováveis híbridos entre os pássaros saíra-ferrugem, Hemithraupis ruficapilla, e saíra-de-papo-preto, Hemithraupis guira, na região que divide os planaltos do Vale do Itajaí, na vertente atlântica do estado de Santa Catarina. Tal fato pode indicar que essa região seja uma zona de hibridação entre as espécies.
A New Route for the Synthesis of Trichloromethyl-1H-Benzo[d]imidazole and (1,2,3- Triazol)-1H-Benzo[d]imidazole Derivatives via Copper-catalyzed N-Arylation and Huisgen Reactions
Authors: Nematpour Manijeh
Published: September 2024

In this study, functionalized 2-(trichloromethyl)-1H-benzo[d]imidazole derivative
with good yields was synthesized using a copper-catalyzed N-arylation reaction of 2-
iodoaniline and trichloroacetonitrile. This reaction was performed by employing the catalytic
value of copper (I) and 1,10-phenanthroline as the ligand in tetrahydrofuran solvent at
23°C. In the following, the reaction of the final product with phenylacetylene and sodium
azide (Huisgen reaction) using the copper catalyst in water solvent at 23°C led to the synthesis
of new (1,2,3-triazol)-1H-benzo[d]imidazole derivatives with the principles of green
chemistry and suitable efficiency. The availability of raw materials and suitable catalysts,
mild reaction conditions, and easy purification are among the advantages of this method for
the synthesis of various multi-substituted benzo[d]imidazole and 1,2,3-triazole derivatives.
Bioactive Compounds Derived from Marine Sources for Cancer Therapy and Chemoprevention
Authors: Indumathy Ramasamy , Kamatchi Thangavel Sathiya , Kalaiaras Giriraj Usha
Published: September 2024

The relatively unexplored marine environment is a rich resource of novel
bioactive candidates that may be beneficial for human beings. Since the marine
environment is complex in nature, living organisms produce secondary metabolites
with unique biological properties that could find applications in health care systems.
This chapter gives an overview of marine-based anticancer drugs that are FDAapproved and bioactive components that are under preclinical and clinical trials. It also
provides insight into marine-based nutraceuticals, their sources, and their usefulness for
various human health concerns. Therefore, exploring the marine environment through
collaborative research work both by academia and industries could lead to significant
contributions to humanity.
Inhibition of Nitric Oxide and Free Radical Production by Leaf and Stem Extracts of Psychotria nilgiriensis
Authors: Thangaraj Parimelazhagan , John Pezzuto M. , Kondratyuk Tamara P. , Park Eun-Jung , Rajan Murugan , Kotchoni Simeon O.
Published: September 2024

Psychotria nilgiriensis was used in traditional medicine as to cure chronic
inflammatory diseases. Therefore, the evaluation of different combination of solventbased fractions from stem and leaves of P. nilgiriensis for free radical scavenging
activity, inhibitory potential against nitric oxide radicals, and tentative identification of
active metabolites were carried out. The antioxidant activity of solvent extracts was
determined by DPPH·
scavenging, TAC, and ORAC assays using spectrophotometer
analysis. Further, nitric oxide production inhibition was studied in lipopolysaccharide
(LPS)-activated macrophages RAW 264.7 cells. Fraction-based bioactive chemical
compound identification was performed using an LC-MS metabolomics approach.
With each of the assays, activity was observed with various extracts derived from both
the stem and the leaf. The two active extracts, one obtained with Psychotria nilgiriensis
leaf ethyl acetate: methanol (PLEM, 40/60 v/v), and another one obtained with P.
nilgiriensis stem chloroform: ethyl acetate (PSCE, 70/30 v/v), about 10-15% of the
chemical components were identified. With PLEM, N,N-bis(2-ethylhexyl)hydroxylamine was higher in concentration, whereas PSCE, N,N-dioctylhydroxylamine was
higher in concentration compared to other metabolites. Thus, the present findings
suggest that the P. nilgiriensis leaf and stem could have medicinal value as an
antioxidant for the treatment of inflammatory diseases. Some of the chemical
constituents such as hydroxylamine derivatives could also be of value.
Effect of Internal Control and Earnings Management on Tax Accounting Aggressiveness
Authors: Nugrahini Erdini , Hariadi Bambang
Published: September 2024

Tax aggressiveness is one of the measures taken by companies by which they aggressively reduce their tax payable by exploiting gray areas in tax regulations. This research attempts to identify the effects of internal control and earnings management on tax aggressiveness using multiple regression analyses performed in SPSS version 24. The research population is food-and-beverage manufacturing companies. The use of the purposive sampling technique and the research period of 2019-2021 resulted in 27 sample companies and 81 observation data. This study finds that internal control and earnings management do not significantly influence tax aggressiveness. The cause of this insignificance might be inefficient internal controls and manager-overriding practices. This study suggests future researchers examine other factors that strongly affect tax aggressiveness. Investors can use the findings of this research to help them determine companies that are suitable for their investing criteria. The government is advised to be more cautious with tax-aggressive actions that might be done by companies that are more difficult to detect.
Abstrak
Agresivitas pajak adalah suatu tindakan perusahaan yang secara agresif mengurangi pajak terutang dengan memanfaatkan area abu-abu peraturan pajak. Penelitian ini berupaya untuk mengetahui pengaruh pengendalian internal dan manajemen laba terhadap agresivitas pajak.  Penelitian ini menggunakan metode analisis regresi berganda dan dianalisis dengan software SPSS versi 24. Adapun populasi penelitian ini adalah perusahaan manufaktur yang terdaftar pada subsector makanan dan minuman tahun 2019-2021 dan sampel diambil menggunakan teknik purposive sampling dengan total akhir sampel berjumlah 27 perusahaan dengan total observasi sejumlah 81 data. Penelitian ini menemukan bahwa pengendalian internal dan manajemen laba tidak berpengaruh secara signifikan terhadap agresifitas pajak. Penyebab dari ketidaksignifikan hipotesis mungkin disebabkan. oleh ketidak efisiensian pengendalian internal dan praktik manager overriding. Implikasi penelitian ini ditujukan kepada tiga peran. Bagi peneliti selanjutnya ialah dapat mengkaji faktor-faktor lain yang lebih mempengaruhi agresivitas pajak, Implikasi bagi investor sebagai referensi dalam menentukan perusahaan mana yang sesuai dengan kriteria mereka, dan bagi pemerintah ialah tetap mewaspadai agresivitas pajak perusahaan yang semakin sulit untuk dideteksi.
Agile-Scrum Implementation in The Development of Kampus Merdeka Information System
Authors:   Del Institute of Technology, Aruan Nenni Mona , Nainggolan Albet Matthew Best , Sipahutar Timothy ,   Del Institute of Technology,   Del Institute of Technology
Published: September 2024

Merdeka Belajar Kampus Merdeka (MBKM) program is a program initiated by the Minister of Education and Culture to encourage students to master various disciplines for their preparation in the job market. At the Institut Teknologi Del, the MBKM program is also offered to students. However, its implementation is not yet fully automated and utilizes various different platforms. This research aims to design and develop the Independent Internship & Study Implementation Information System in the Merdeka Campus at the Institut Teknologi Del using the Agile-Scrum approach. The Scrum method is an iterative software development approach that is flexible to changes. The implementation of Agile-Scrum in the development of the MBKM information system helps achieve goals and automate existing systems. This research involves Scrum activities such as sprint planning, daily scrum, sprint review, and sprint retrospective to produce an information system that meets the requirements. The Scrum product backlog is used as a reference during system development throughout the sprint. The development of the information system through agile-scrum has received feedback during the sprint review and has been functionally tested using several testing methods.
Device-based circumcision: advantages, choice of device and surgical technique
Authors: Kotov S. V. , Pavlov I. S. , Korochkin N. D. , Alekberov E. M.
Published: September 2024

Introduction. Circumcision is one of the most common surgical procedures for men. WHO programs aimed at reducing HIV transmission have led to the development of various circumcision devices designed to standardize surgical techniques, reduce operating time and the number of complications.

Objective. To examine available data on the efficacy and safety of different methods of device-based circumcision.

Materials & methods. The results of a search in scientific databases such as eLibrary and PubMed were analyzed using the keywords: "circumcision", "circumcision device", and "phimosis". The search was conducted without regard to date or language of publication. After reviewing the literature, 25 articles were selected that best reflect the topic of device-assisted circumcision for further analysis.

Results. Device-based circumcision can significantly reduce surgical time, regardless of the type of device used. Device-based circumcision is the safe treatment method; however, it may have a higher incidence of adverse events compared to the standard circumcision technique. The use of self-suturing devices is preferred over ring devices due to fewer complications, better cosmetic results, and greater patient satisfaction. The article is supplemented with a description of the surgical technique of various options for device-based circumcision.

Conclusion. Device-based circumcision is effective and safe treatment method on an outpatient basis, which successfully competes with conventional circumcision of the foreskin.
Replacement of extended ureteral strictures in children: a multicenter experience with appendicoplasty
Authors: Kagantsov I. M. , Pelikh K. I. , Dubrov V. I. , Sizonov V. V. , Shmyrov O. S. , Kontratyeva E. A.
Published: September 2024

Introduction. The first description of ureteral appendicoplasty was provided by the Italian surgeon Giannettasio in 1901, followed by two German surgeons, Franke and Rydygier. Their work was later included in a review by Melnikoff in 1912. However, it is Melnikoff who is often erroneously credited with performing the first appendicoplasty in the literature. The first ureteral appendicoplasty operation on a 1.5-year-old child in Russia was performed by Soloviev in 1976.

Objective. To report the results of performing operations on replacement of ureteral defects by ureteral appendicoplasty in children.

Materials & Methods. Between 2009 and 2023, a total of 11 surgeries were conducted to replace extended ureteral defects using the appendix technique in four clinics in Russia and the Republic of Belarus. The follow-up included six boys and five girls with an average age of 79 months (ranging from 18 months to 16 years). Six operations were performed by laparoscopic access (mean operative time 356 minutes). Five operations were performed by open access (mean operative time 257 minutes).

Results. Long-term results were assessed between 18 and 192 months in all patients. Urinary tract patency was evaluated based on the results of micturition cystography (in one case, vesicoureteral reflux was recorded) and intravenous urography (one case of stenosis of the distal anastomosis, which was corrected by endoscopic dissection of the stricture site using a fiberoureteroscope). In patients who underwent renoscintigraphy, no progression of renal function decline was observed. In all patients, long-term follow-up showed satisfactory urine passage.

Conclusion. The results of the surgical interventions performed by us are assessed as good. In all 11 cases, the replacement of the extended ureteral stricture using an appendix allowed for the restoration of urinary flow. Furthermore, any complications that arose did not necessitate repeated reconstruction of the urinary tract. Nevertheless, it is important to note that, in our opinion, this technique cannot be considered the method of choice. Rather, it represents a last resort for patients who have undergone multiple previous operations due to severe trauma or oncological diseases. In cases involving ureteral strictures, priority should always be given to an operation involving anastomosis with sufficient ureteral length and minimal tissue tension. We firmly believe that this approach offers the best chance for a successful outcome.
Oral donor site evaluation in the early and late postoperative periods for augmentation and replacement urethroplasty
Authors: Iritsyan M. M. , Klimenko A. A. , Mantsov A. A. , Suyundikov I.-N. K. , But A. P. , Rakhmatov R. A. , Prismakova M. V. , Alekberov E. M. , Kotov S. V.
Published: September 2024

Introduction. The use of oral mucosa in augmentation and replacement urethroplasty is the gold standard for several reasons. Most commonly, the mucous membrane of the cheek, the underside of the tongue or lip is employed. Assessing postoperative complications in the donor area is crucial as it impacts patients' quality of life.

Objective. To evaluate early and late postoperative changes in the donor area after oral graft extraction for urethroplasty

Materials & methods. A retrospective analysis of the results of surgical treatment using oral mucosa from 2017 to 2022 was carried out. The study included 65 patients. The intensity of pain syndrome in the graft sampling area was assessed by patients on a visual analog scale (VAS). The donor area was sutured only in the case of tongue and lip mucosa sampling.

Results. The mucous membrane of the oral cavity was harvested from different sites in 65 patients. Specifically, it was taken from the inside of the cheek in 49 patients (75.38%), from both inner sides of the cheeks in 13 (20.0%), the lower lip in two (3.07%) and the lower surface of the tongue in one (1.54%) patient, respectively. On the first day after surgery, the median pain level according to VAS was 4 points (range: 2 – 7), at the time of discharge — 3 points (1 – 6). After 120 days, a follow-up examination showed a regression of pain symptoms: the median was 0 points (0–1). In the late postoperative period, incomplete opening of the mouth was recorded in two patients (3.07%), cosmetic defect in the donor area in two (3.07%), discomfort during meals in six (9.23%), impaired sensitivity in the donor area in two (3.07%), exacerbation of chronic stomatitis and hypersalivation in two (3.07%) patients, respectively.

Conclusion. The incidence of complications in the donor area is low, but for some patients this can result in a reduced quality of life. Using proper technique when extracting oral mucosa grafts reduces pain and the likelihood of early- and late-stage postoperative complications in this area.
Lymphoblock surgical solution for the prevention of lymphogenic complications during robot-assisted radical prostatectomy and pelvic lymphadenectomy: first-use experience
Authors: Skrupskiy K. S. , Kolontarev K. B. , Govorov A. V. , Dyakov V. V. , Lukin A. M. , Dzhumabaev B. I. , Pushkar D. Yu.
Published: September 2024

Introduction. The clinical guidelines recommend performing extended pelvic lymph node dissection for patients with intermediateor high-risk cancer prostate. The incidence of lymphocele development reaches 10.3%.

Objective. The aim of this study was to evaluate the efficiency of the drug Lymphoblock after radical prostatectomy with pelvic lymphadenectomy.

Materials & methods. The study involved 79 patients with prostate cancer who underwent robot-assisted radical prostatectomy with pelvic lymphadenectomy, that were randomized into three treatment groups: 1. Patients with free peritoneal flap fixed to the pubic bone (n = 26); 2. Patients who received Lymphoblock: during the surgery (n = 26); 3. Control group (n = 27). The median follow-up was 180 d.

Results. In postoperative period lymphocele was diagnosed in 8 (10.1%) patients: group 1 — 2 (7.7%) patients, group 2 — 1 (3.8%), group 3 — 5 (18.5%). Lymphocele had no clinical manifestation in group patients who received Lymphoblock.

Conclusions. Preliminary results of Lymphobloc use indicate that it can reduce the incidence of lymphogenic complications in the postoperative period in patients undergoing robot-assisted radical prostatectomy with pelvic lymphadenectomy.
The Impact of Air Pollution Information on Individuals’ Exercise Behavior: Empirical Study Using Wearable and Mobile Devices Data
Authors: Yang Yang , Goh Khim-Yong , Teo Hock Hai , Tan Sharon Swee-Lin
Published: September 2024

Background

Physical exercise and exposure to air pollution have counteracting effects on individuals’ health outcomes. Knowledge on individuals’ real-time exercise behavior response to different pollution information sources remains inadequate.

Objective

This study aims to examine the extent to which individuals avoid polluted air during exercise activities in response to different air pollution information sources.

Methods

We used data on individuals’ exercise behaviors captured by wearable and mobile devices in 83 Chinese cities over a 2-year time span. In our data set, 35.99% (5896/16,379) of individuals were female and 64% (10,483/16,379) were male, and their ages predominantly ranged from 18 to 50 years. We further augmented the exercise behavior data with air pollution information that included city-hourly level measures of the Air Quality Index and particulate matter 2.5 concentration (in µg/m3), and weather data that include city-hourly level measures of air temperature (ºC), dew point (ºC), wind speed (m/s), and wind direction (degrees). We used a linear panel fixed effect model to estimate individuals’ exercise-aversion behaviors (ie, running exercise distance at individual-hour, city-hour, or city-day levels) and conducted robustness checks using the endogenous treatment effect model and regression discontinuity method. We examined if alternative air pollution information sources could moderate (ie, substitute or complement) the role of mainstream air pollution indicators.

Results

Our results show that individuals exhibit a reduction of running exercise behaviors by about 0.50 km (or 7.5%; P<.001) during instances of moderate to severe air pollution, and there is no evidence of reduced distances in instances of light air pollution. Furthermore, individuals’ exercise-aversion behaviors in response to mainstream air pollution information are heightened by different alternative information sources, such as social connections and social media user-generated content about air pollution.

Conclusions

Our results highlight the complementary role of different alternative information sources of air pollution in inducing individuals’ aversion behaviors and the importance of using different information channels to increase public awareness beyond official air pollution alerts.
Digital Health Tool for Preventing Blindness from Diabetic Retinopathy: Protocol for a Qualitative Study (Preprint)
Authors: Frimpong Akua , Granados Alvaro , Chang Thomas , Fu Julia , Applebaum Serina S , Kaur Mahima , Adepoju Bolatito , Moore Shannan G , Hari Krishnan Vignesh , Levi Amanda , McCall Terika , Nwanyanwu Kristen Harris
Published: September 2024

BACKGROUND

Diabetic retinopathy (DR), a leading cause of preventable blindness among working-aged adults, leads to worse health outcomes among Black, Latine, and low-income individuals in comparison to other ethnic, racial, and socioeconomic groups in the United States.

OBJECTIVE

We aim to engage community members directly to identify barriers and facilitators of DR screening and co-design a digital health tool that is accessible, user-friendly, and community responsive.

METHODS

We conducted focus groups with individuals from the Greater New Haven, Connecticut area age 18 years and older and diagnosed with diabetes to (1) conduct a comprehensive disease-management needs assessment and (2) inform development of a community-responsive digital health tool to optimize DR education and to increase access to DR screening in high-risk populations. We transcribed the focus group interviews, used rapid qualitative analysis to generate themes, and completed affinity mapping to identify content and features for a digital health tool for preventing blindness from diabetic retinopathy.

RESULTS

As of December 2023, we completed 4 focus groups with 19 participants who have a diagnosis of diabetes.

CONCLUSIONS

We anticipate that the study will characterize the experiences of people living with a chronic disease such as diabetes. Using a community led approach, we will analyze the information which will generate insights regarding the key benefits that are most important for the creation of a digital health tool.
Optimizing the Color Shapes Task for Ambulatory Assessment and Computational Cognitive Feature Extraction via Drift Diffusion Modeling (Preprint)
Authors: Kim Sharon Haeun , Hakun Jonathan , Li Yanling , Harrington Karra D , Elbich Daniel B , Sliwinski Martin J , Vandekerckhove Joachim , Oravecz Zita
Published: September 2024

BACKGROUND

Recent advances in cognitive digital assessment methodology, including high-frequency, ambulatory assessments, have shown promise to improve the detection of subtle cognitive changes. The use of computational modeling approaches may further improve the sensitivity of the digital cognitive assessments to detect subtle cognitive changes by capturing features that reflect core cognitive processes from non-cognitive/non-decision-related processes.

OBJECTIVE

We explored the validity of a brief, smartphone-based adaptation of an associative visual working memory change detection task that has shown sensitivity in the early detection of preclinical AD-related cognitive impairment. We aimed to optimize the task for computational cognitive feature extraction with drift diffusion modeling.

METHODS

We analyzed data from a sample of 68 participants (69% women; 81% White; age range 24-80 years, mean 49 years, SD 14), who completed 60 trials for each of the 16 variations of a Visual Working Memory Binding task (‘Color Shapes’) on smartphones, over an 8-day period. A drift diffusion model was fit to Color Shapes response time and accuracy data to dissociate features of the decision-making process. We experimentally manipulated three properties of the Color Shapes task (study time, probability of change, choice urgency) to test how these constraints yield differences in key computational features (rate of evidence accumulation process, initial bias towards a response option, caution in decision making). We also evaluated how an additional task property, the test array size (whole display vs. single probe), impacted responses across all conditions.

RESULTS

Overall accuracy was high (>80%) and minimal missingness (1.3% of expected data) was observed. Three primary observations were made regarding the task property manipulations and drift diffusion model fit: (1) increasing the probability of change was associated with higher ‘initial bias’ toward a “different” response, (2) increasing the choice urgency during the test phase was associated with decreased caution in decision-making (‘boundary separation’), and (3) contrary to expectation, longer study times did not affect evidence accumulation rate (‘drift rate’). In addition, we observed that individual differences in evidence accumulation rate (drift rate) and caution (boundary separation) were associated with age.

CONCLUSIONS

We identified a version of the Color Shapes task that is ideal for smartphone-based, repeated cognitive assessments in real-world settings, especially when the resulting data are analyzed through computational cognitive modeling. Our proposed approach can advance the development of tools and programs for an efficient and effective early detection and monitoring of early risk for Alzheimer’s disease.

CLINICALTRIAL

N/A
Approaches to Mobile App-based Cardiac Rehabilitation: A Systematic Review (Preprint)
Authors: Witharana Pasan , Sherif Mohamed , Shafiq Umar , Wilkinson Chris , Athanasiou Thanos , Akowuah Enoch
Published: September 2024

BACKGROUND

The European Society of Cardiology recommends cardiac rehabilitation for all patients with acute coronary syndrome, which may be facilitated through mobile applications using physical activity monitoring and goal setting. This systematic review aims to identify and summarize which techniques are employed by mobile app-based cardiac rehabilitation programs.

OBJECTIVE

The aim of this systematic review is to identify and summarise the techniques that are used by mobile application based cardiac rehabilitation programmes and their effectiveness.

METHODS

We searched Embase, Medline and CINAHL from their inception to 15/5/2024 for articles describing the use of mobile apps within a cardiac rehabilitation programme.

RESULTS

24 articles were included, detailing the use of physical activity monitoring devices, goal setting, motivational messaging, phone and video calls, and web portals. Of these, 10 described physical activity monitoring devices, and 23 discussed goal setting. Several of these articles were small-scale feasibility studies. Home-based CR programmes offered greater patient choice and improved participation. These programmes often involved strategies such as activity tracking and goal-setting.

CONCLUSIONS

Home-based CR programmes delivered via mobile apps offer a convenient alternative for patients unable to attend hospital-based CR programmes. These apps personalize rehabilitation plans through features like activity tracking and custom goal setting, potentially improving engagement and adherence. Larger clinical trials with longer follow-up periods are needed to assess their full effectiveness.
Performance Analysis of Front-Line Demonstrations on Green Gram (Vigna Radiate l.) in Jodhpur District of Western Rajasthan
Authors: Puniya Manmohan , Choudhary Desh Raj
Published: September 2024

Pulses being rich in quality protein, minerals and vitamins are inseparable ingredients of diet of majority of indian population. Despite high nutritive value of pulses and their role in sustainable agriculture desired growth rate in production could not be witnessed. The domestic production of pulses is consistently below the targets and actual domestic requirements are also higher, due to this pulses are being imported. The Krishi Vigyan Kendra, Jodhpur-II (Phalodi) has carried out frontline demonstrations on greengram crop varieties GM-6 and IPM 205-7 covering an area of 30 ha of farmer's field to exhibit latest production technologies and compared it with farmer's practice. The study in total 50 frontline demonstrations were conducted on farmer's fields in villages viz. Kali-mali and Baori of Jodhpur district of Rajasthan state during 2020 and 2022, to demonstrate production potential and economic benefit of improved technologies comprising sowing method, nutrient management and chemical weed management and adoption of whole package of practices for crop. After sowing of seed, application of weedicide Imazethapyr 10SL as early post emergence at 50 gm a.i. per ha in 500 liters of water used for effective control of the weeds during kharif season in rainfed condition. The findings of the study revealed that the demonstrated technology recorded a mean yield of 687 kg/ha which was 23.7 % higher than obtained with farmers practices (555 kg/ha). Higher mean net income of Rs. 31285/ha with a Benefit:cost ratio of 3.05 was obtained with improved technologies in comparison to farmers practices (24710).The frontline demonstrations conducted on greengram crop at farmer’s field revealed that the adoption of improved technologies significantly increased the yield as well as yield attributing traits of crop and also the net neturns higher than the farmer’s practices. So, there is a need to disseminate the improved technologies among the farmers with effective extension methods like training and demonstrations. The farmers should be encouraged to adopt the recommended package of practices realizing for higher returns.
Rubén Darío y las textualidades católicas de El Tiempo Ilustrado
Authors: Reynolds Andrew
Published: September 2024

El artículo explora la relación entre el movimiento modernista —liderado por el poeta nicaragüense Rubén Darío— y la expresión católica en México a principios del siglo XX, a través de un análisis de El Tiempo Ilustrado, editado por Victoriano Agüeros. El Tiempo Ilustrado tenía como objetivo principal crear una publicación que registrara la cultura nacional mexicana, con marcada influencia de la Iglesia católica. No obstante, la autoridad estética del modernismo durante ese periodo y el prestigio de Darío permearon sus páginas, generando una negociación entre el movimiento secular cosmopolita y los propósitos religiosos de la revista. Este estudio examina cómo el catolicismo influyó en Darío y en el modernismo, al igual que en su expresión poética, y analiza de qué manera este movimiento estético intervino en la revista católica mexicana más popular de la época.
Literatura exiliada. Victoriano Salado Álvarez: centroamericanista
Authors: Shuttera Alejandro Sacbé , Weber Fonseca Albert
Published: September 2024

Este artículo tiene tres ejes fundamentales: 1) Esbozar una reflexión teórica sobre una posible “literatura del exilio” como género, a partir de distinguir sus definiciones, particularidades conceptuales y principales tipologías. 2) Presentar al escritor mexicano Victoriano Salado Álvarez como un “autor del exilio”, paradójicamente atado a fuertes vínculos de nacionalidad. 3) Narrar su experiencia en el exilio centroamericano durante la Revolución mexicana, y a la vez mostrar su legado en la cultura, las costumbres y, especialmente, en la historia política de esa región, con la convicción de ver en este autor a un notable centroamericanista, veta tan fascinante como poco estudiada no sólo en su extensa obra, sino en la historia de la literatura mexicana.
Umbrales de lo postsecular: ilustraciones de portada y narrativa española contemporánea
Authors: García Donoso Daniel
Published: September 2024

Este artículo propone un acercamiento intermedial a la configuración simbólica de lo postsecular, atendiendo al espacio de cruce entre el texto propiamente literario (novela-texto) y el texto visual de la ilustración de portada (novela-libro). En la medida en que existe una literatura postsecular en el contexto español, nos interesa adentrarnos en el análisis de cómo las imágenes que ilustran dichas publicaciones interactúan, por un lado, con ese mismo concepto de lo postsecular en la configuración de una imagen autónoma y, por otro, con un texto con el que la imagen establece una relación de interpretación mutua. Este análisis revela la función de estas representaciones visuales como portales de paso al complejo diálogo que existe entre temas religiosos y narrativas contemporáneas, y entre éstos y la cultura visual del momento. El análisis versará sobre tres obras narrativas publicadas en España desde finales del siglo XX hasta la actualidad, que tienen un particular encaje en la reflexión sobre lo religioso en el momento contemporáneo postsecular: El hereje (1998) de Miguel Delibes, Crematorio (2007) de Rafael Chirbes y Pasión del dios que quiso ser hombre (2014) de Rafael Argullol.
Research on the Simulation and Optimization of Wind Environment in School Canteen based on Airpak
Authors: Zan Guo
Published: September 2024

In order to explore the ventilation status of the school canteen, maintain the freshness of the air in the densely populated area, investigate the natural ventilation situation, formulate the corresponding natural ventilation strategy, and maintain a good ventilation effect, the simulation and optimization study of the canteen wind environment was carried out based on Airpak, and the simulation results were evaluated according to the analysis and evaluation of indoor wind environment parameters, and the ventilation strategy was optimized.
Perlindungan Hukum Terhadap Kerugian Konsumen Sebagai Akibat Kelalaian Perusahaan Daerah Air Minum
Authors: I Nyoman Bangkit Sugiarta  , I Nyoman Putu Budiartha  , Ni Made Puspasutari Ujianti
Published: September 2024

Perlindungan hukum yang diberikan oleh PDAM kepada konsumen sebagai pengguna barang dan jasa akibat keterbatasan pasokan air bersih. Untuk mengetahui bagaimana tanggung jawab PDAM dalam mengatasi kerugian yang dialami konsumen terhadap akibat yang timbul dari terbatasnya pasokan air bersih. Metode yang digunakan adalah yuridis empiris, Hasil penelitian menunjukkan bahwa Undang-Undang Nomor 8 Tahun 1999 tentang Perlindungan Konsumen merupakaan landasan hukum yang pertama dan utama dalam menyelesaikan permasalahan dan kasus konsumen yang mengalami kerugian akibat pelaku usaha yang kurang menyadari hak dan kewajibannya dalam menjalankan usaha. Berdasarkan peraturan perundang-undangan, PDAM bertanggung jawab atas kerugian yang diderita konsumen/pelanggan, yaitu mengganti kerugian dengan melakukan perbaikan kerusakan jaringan pipa yang dikelola oleh PDAM Denpasar yang mengakibatkan kerugian finansial bagi konsumen/pelanggan. Peraturan Daerah Kota Denpasar Nomor 3 Tahun 2009 tentang Perusahaan Daerah Air Minum Minim Kota Denpasar diatur dalam Pasal 2. Dengan pembahasan yang dipermasalahkan maka dapat disarankan bagi PDAM agar perlu membuat aturan yang jelas berkaitan dengan pemberian air bersih kepada konsumen apabila terjadi kekeringan yang mengakibatkan terbatasnya sumber air baku, sehingga masyarakat tidak Kekeurangan air bersih dan kepada konsumen , jika konsumen mendapatkan debit aliran air yang kecil maka konsumen langsung melakukan komplain ke PDAM, agar PDAM segera menindaklanjuti laporan konsumen.