bluuebunny/crossref_metadata_2025 huggingface dataset:
SMOKING: A RISK FACTOR AFFECTING CHOROIDAL THICKNE
Authors: Kapad Pooja , Karhana Ekta , Arora Vanshika , Singh Jaishree
Published: November 2024

Background: The tobacco epidemic is one of the biggest public health threats the world has ever faced, killing over 8
million people a year around the world. As a highly modifiable environmental factor, smoking was reported to be
associated with kinds of ocular disorders, including age-related macular degeneration (AMD), glaucoma, ischemic
optic neuropathy,and retinal vein occlusion.Methodology: This cross sectional study was performed in department of
ophthalmology of government medical college, kota after taking informed consent from all the participants.The study
was approved by the institutional review board. 25 healthy smokers (study group) and 25 non-smokers (control group)
were enrolled. All patients were seen and examined in OPD of Ophthalmology Department. Enhanced depth imaging
optical coherence tomography (EDI) using SD-OCT was performed. Results: A history of smoking was significantly
associated with a thinner choroid across all patients via logistic regression (P=0.003).Mean macular choroidal thickness
was thinner for smokers (145±62 m) than for nonsmokers (185±60 m) among all diagnosis categories (P=0.004).
Study also revealed an association between increased pack-years of smoking and a thin choroid across all patients
(P<0.001). Conclusion: In conclusion, significant effect of cigarette smoking on retinal or choroidal thickness change
was detected. Choroidal thickness was found reduced in smokers. For smoking-related chorioretinal diseases, the
conclusions of this research provides ideas for follow-up studies. In addition, future research on this interesting and
meaningful point would help in the prevention and treatment of smoking-associated disorder
A CLINICOMYCOLOGICAL STUDY ON DERMATOPHYTOSIS AND ANTIFUNGAL DRUG SENSITIVITY BY DISC DIFFUSION METHOD
Authors: Maharshi Aradhana , Kothiwala Rajkumar , Kumar Gulshan
Published: November 2024

Background: Dermatophytosis is the most common superficial fungal infection across India and worldwide.
Dermatophytoses refer to superficial fungal infection of keratinized tissues caused by keratinophilic dermatophytes.
Recently there is a shift in epidemiology from T.rubrum to T.mentagrophytes and antifungal resistance is increasing
alarmingly. Objective: To assess the clinical profile of dermatophytosis and to identify the prevalent species and
antifungal sensitivity pattern. Methods:100 newly clinically diagnosed cases of dermatophytosis who were not under
any topical treatment for the past 1 month were enrolled. Direct microscopy and culture followed by antifungal
susceptibility was done in each case.Results: The most common clinical diagnosis was Tinea corporis et cruris (35%)
followed by Tinea crusis (18%).Direct Microscopy( KOH )and culture showed positivity in 61% and 64% of samples
respectively .Trichophyton mentagrophytes was the predominant dermatophyte isolate in 42 % followed by T.rubrum in
12%. Voriconazole was the most sensitive drug with sensitivity of 75% -100% followed by Itraconazole 66.7%-
100%.Fluconazole was least sensitive drug 0%-66.7% followed by Terbinafine 25%-33.3 %. Conclusion: This study
concluded that the causative agent for the dermatophytosis was changing in India and in our area Trichophyton
mentagrophytes has replaced Trichophyton rubrum as the predominant species causing dermatophytosis .
Voriconazole and Itraconazole were the most effective drugs and Fluconazole and Terbinafine were least effective .
CLINICORADIOLOGICAL PROFILE OF POSTTUBERCULOSIS LUNG DISEASE: AN OBSERVATIONAL STUDY IN PATIENTS AT A TERTIARY CARE HOSPITAL IN INDORE, MADHYA PRADESH
Authors: Salam V. A Halma , Avashia Sanjay , Tripathi P. S
Published: November 2024

Aims And Background: Tuberculosis, caused by Mycobacterium tuberculosis remains a major global health
challenge,particularly in Southeast Asia and sub-Saharan Africa. Post-tubercular lung disease (PTLD) is characterized
by chronic respiratory abnormalities linked to previous tuberculosis leading to structural and functional impairments in
the lungs.Historically,PTLD has been underestimated as a cause of chronic lung illness.However, recent data highlight
the significant burden and long-term health challenges faced by TB survivors,including increased mortality rates.This
study examines the clinic-radiological aspects of PTLD in a high TB burden country like India.Materials And Methods:
It was a single centre observational study at a tertiary care centre in Indore, Madhya Pradesh. After applying the
inclusion criteria and obtaining informed consent data was collected from 120 patients including demographics,clinical
symptoms, comorbidities, and radiological changes. Dyspnoea severity was assessed with the mMRC scale, and
functional impairment was measured using the 6-minute walk test. Results: Out of the 120 cohort mean age was 47.4
years with 55.8% male. Common symptoms included cough (86.7%) and shortness of breath (80%) followed by
haemoptysis and chest pain. Most common radiological changes were fibrosis (90%) and bronchiectasis (60%),
cicatrisation/volume loss (55.8%) and calcifications (43.3%). Moderate to severe PH was linked to higher dyspnoea
scores and significant desaturation post-6MWT. Conclusion: Research on post-tubercular lung disease (PTLD) is vital
due to its lasting impact,causing chronic respiratory issues,lung damage,and decreased quality of life.Understanding
PTLD aids in improving rehabilitation,treatment protocols,and public health policies to mitigate TB's long-term effects.
A RARE CASE OF PARA TESTICULAR FIBROUS PSEUDOTUMOR
Authors: Mali Paresh , Taral Sandip , Singh Shubham
Published: November 2024

Paratesticular pseudotumors are rare benign lesions that can mimic malignancies in clinical presentation. They are often
confused with malignant tumors due to the lack of distinctive symptoms and imaging findings. Accurate diagnosis relies
on histopathological examination after surgical excision. This case report discusses a rare presentation of a
paratesticular pseudotumor in a 22-year-old male who presented with an asymptomatic scrotal mass with normal blood
investigation and tumor marker. USG and MRI reveal paratesticular fibrous pseudotumor. High inguinal orchidectomy
done in view of size and non-separable from testis underscoring the importance of considering pseudotumors in
differential diagnoses of scrotal masses. The findings in this report highlight the clinical, diagnostic, and management
aspects of paratesticular pseudotumors.
A preregistered meta-meta-analysis on the global distribution of Hepatotropic Viruses
Authors: Adeiza Shuaibu Suleiman , Islam Md. Aminul , Mungadi Hauwa’u Umar , Shuaibu Abdulmalik Bello , Sah Ranjit
Published: November 2024

Introduction. Hepatotropic viruses (HAV, HBV, HCV, HDV, and HEV) significantly impact global health, with varying prevalence across regions.
Objective. This study aims to systematically consolidate data from diverse meta-analyses to provide a contemporary reference on virus distribution and prevalence.
Materials and methods. Adhering to PRISMA guidelines, the study utilized a mixed effects model for data integration. Quality evaluation was carried out with QUOROM and AMSTAR tools, with heterogeneity assessed via the Higgins I2 statistic, Q-statistic and Tau squared (τ2) values.
Results. The study analyzed 86 meta-analyses from 56 studies (2017–2022) with minimal overlap. Prevalence rates by region were as follows: MENA – 29.2%, Afghanistan – 9.14%, Africa – 8.10%. Prevalence rates by virus type: HAV – 82.5%, HBV – 8.6%, HCV – 15.1%, HDV – 8.9%, HEV – 13.9%, dual HBV-HCV coinfection – 2.2%. Prevalence rates by risk groups: general population – 8.3%, healthcare workers – 4.0%. Continent-specific HBV-HCV prevalence rates: Africa – 9.2%, China – 6.9%, others. HCVprevalence rates among at-risk groups: healthcare workers – 5.58%, hemodialysis patients – 34.8%. Regional HCV rates: Africa – 7.42%, Middle East – 25.30%.
Conclusion. Diverse global hepatotropic virus prevalence patterns are influenced by multifaceted factors. MENA faces higher rates due to healthcare challenges, while Africa struggles with limited resources. Tailored public health strategies, including vaccination and awareness campaigns, are essential to alleviate burdens and enhance global health. This consolidated data serves as a valuable resource for informed decision-making.
Mutations in human cytymegalovirus (Orthoherpesviridae: Herpesvirales: Cytomegalovirus: Cytomegalovirus humanbeta 5) UL97 gene lead to increase in viremia duration and poor antiviral response in recipients of allogeneic hematopoietic stem cells
Authors: Tikhomirov Dmitriy S. , Demin Mikhail V. , Serikova Anastasia A. , Biderman Bella V. , Sudarikov Andrey B. , Filatov Felix P. , Tupoleva Tatiana A.
Published: November 2024

Introduction. Human cytomegalovirus (Orthoherpesviridae: Herpesvirales: Cytomegalovirus: Cytomegalovirus humanbeta 5) (HCMV) is one of the most commonly detected viruses in recipients of allogeneic hematopoietic stem cell (allo-HSCT) transplants. However, the emergence of resistance to antiviral drugs such as ganciclovir (GCV) poses a challenge in managing these patients.
This study aims to investigate the prevalence and impact of mutations in the HCMV UL97 gene associated with resistance to GCV on the course of infection among allo-HSCT patients.
Materials and methods. The study examined the association between UL97 mutations and the clinical course of HCMV infection in allo-HSCT patients. Genetic sequencing was performed to identify mutations, and their impact on viral replication and resistance to GCV was assessed.
Results and discussion. Six mutations were identified (D490A, T502A, C592G, C592F, E596G, C603W). C592G, C592F, E596G, and C603W are associated with resistance to antiviral drugs, while D490A and T502A described for the first time. When comparing patients with wild-type and those carrying the mutant variant, several parameters of peripheral blood were significantly lower in the former group. The median time to peak viral load following allo-HSCT, duration of viremia, and rate of virological response to high-dose therapy also differed significantly between the two groups.
Conclusion. It was shown that approximately one third (4 out of 14) of allogeneic stem cell transplant recipients had mutations associated with resistance to GCV. Patients carrying the mutant variant of HCMV had longer viremia and took longer to achieve a negative virological test result after starting high-dose therapy. Performing genotyping may help make more evidence-based therapeutic decisions.
Defective HIV proviruses: possible involvement in the HIV infection pathogenesis
Authors: Bobkova Marina R.
Published: November 2024

This review article analyzes information obtained from a literature search on defective HIV genomes (HIV-1, Human Immunodeficiency Virus, Lentivirus, Orthoretrovirinae, Retroviridae). It discusses the origins of defective HIV genomes, their potential for transcription and translation, and the role of defective RNA and proteins in stimulating both innate and adaptive immunity. The article also explores their contribution to HIV pathogenesis, immune system hyperactivation despite successful antiretroviral therapy (ART), and the evolutionary processes in HIV proviral populations under ART. Additionally, it addresses challenges in reservoir elimination and HIV eradication that arise from the existence of defective HIV viruses.
Comparative analysis of whole-genome sequences of African swine fever virus (Asfarviridae: Asfivirus) isolates сollected on the territory of the left bank of the Dnieper River in 2023
Authors: Chernyshev Roman S. , Igolkin Alexey S. , Zinyakov Nikolay G. , Chvala Ilya A.
Published: November 2024

Introduction. The lack of data on the whole-genome sequences of African swine fever virus (ASFV) variants circulating on the territory of the left bank of the Dnieper River complicates the understanding of the molecular evolution of the virus and the character of the epidemic process development in Russia and Ukraine. Understanding the genetic divergence and phylogenetic relatedness of isolates can largely adjust the strategy of general and specific prevention of the disease.
The aim of the study – search and description of unique mutations (deletions/insertions/substitutions) in isolates collected from domestic pigs in Donetsk, Luhansk and Zaporozhye regions in 2023; determination of relatedness and level of homology with reference strains of ASFV genotype II; sub-genotyping and clustering of isolates based on whole-genome analysis.
Materials and methods. The samples used were a culture suspension of porcine bone marrow (PBM) cells containing ASFV isolates obtained from pathologic material from domestic pig carcasses. Genomic DNA was prepared by purification and concentration of virus followed by phenol-chloroform extraction of total nucleic acid. The high-throughput sequencing process was performed using MGI technology. Consensus sequences were assembled by mapping reads to the reference genome of strain Georgia 2007/1.
Results. All isolates are assigned to genotype II, have a monophyletic origin, are phylogenetically close to the clusters «Europe» (4/5) and «Bryansk 2021» (1/5), and are divergent from the original parental genetic variants that make up the enlarged clades. In addition, numerous substitutions in the loci of the multigene family MGF 110, 505, and 360, encoding virulence proteins, were detected in 4 isolates from Donetsk and Zaporozhye regions.
Conclusion. The phylogeny of the genotype II ASFV, which originated from the reference strain Georgia 2007/1, is shown to be sufficient for isolate differentiation. The presented data are of theoretical and practical importance for domestic and international ASFV surveillance.
How European consumers value wine credence attributes: a cross-country comparison of France, Greece and Italy
Authors: Zanchini Raffaele , Blanc Simone , Theodorakis Stefanos , Di Vita Giuseppe , Merlino Valentina Maria , Brun Filippo , Massaglia Stefano
Published: November 2024

Several attributes can be used to differentiate wine products to meet consumer interest and thus increase producer visibility, attractiveness and revenues. The perception towards the same attribute may depend on various factors that characterise the subjects, such as individual, behavioural and situational characteristics, like their country of origin. This study aims to identify which credence attributes and related levels motivate consumers the most to buying wine, by comparing the results obtained in three different European countries: France, Greece and Italy.
A conjoint experiment based on linear assumption was administered using price, production method, geographical indication and wine origin as product attributes. The conjoint data were analysed in three steps: performing a model with the whole sample; performing three models using national data to compare results between the countries; performing a cluster analysis using the Ward method to associate consumer characteristics with product attributes.
 Results show that origin is the most valued attribute for choosing wine, followed by the production method. Cross-country evaluation reveals several significant differences among the attributes of the production method, geographical indication and origin. The cluster analysis identified three groups named: High price and national wine seekers; Certification seekers and Price-sensitive seekers.
This paper provides several implications for both academicians and enterprises. Indeed, it is the first evaluation comparing the role given by consumers to biodynamic certification in a cross-country evaluation. Several indications are also provided for producers who can help differentiate better wine production by earning a higher income.
A Lean Six Sigma, Industry 4.0 and Circular Economy-driven methodology for wine supply chain process improvement
Authors: Zironi Alessandro , Danese Pamela , Romano Pietro , Zironi Roberto
Published: November 2024

Scientific literature recognizes that Lean Six Sigma (LSS), Industry 4.0 (I4.0) and Circular Economy (CE) offer significant opportunities to improve operational performance and decrease the environmental impact. Wine supply chains represent a strategic asset for the world economy and an ideal setting for the implementation of LSS, I4.0 and CE, but studies that integrate these three approaches to improve wine supply chain processes are lacking. The present research intends to demonstrate how wine supply chain processes (SCPs) can be improved by deploying the synergies between LSS, I4.0 and CE, so as to face the quality, efficiency and sustainability challenges modern competition poses to wine companies. To this aim, this study proposes an original methodology that adopts a step-by-step procedure inspired by the Define-Measure-Analyze-Improve-Control (DMAIC) cycle to systematically improve SCPs throughout the different phases of wine supply chains (i.e., vineyard, cellar, distribution). The methodology has been conceptualized starting from three sources - review of scientific literature, interviews with experts and personal contribution – and assembles in an original way some concepts and tools referring to different bodies of literature such as strategic decision making, data-driven process improvement, lean management, industry 4.0 and circular economy. The methodology has been tested in a real case to evaluate its utility for practice and relevance.
Examining the impact of wine influencers’ characteristics on consumer attitudes, purchase intention, and actual wine purchase
Authors: Piramanayagam Senthilkumaran , Mallya Jyothi , Kelkar Vageesh Neelavar
Published: November 2024

Wine influencers have emerged as one of the crucial elements in shaping consumer perceptions and behaviours. However, the specific characteristics of these influencers that effectively influence consumer attitudes, purchase intentions, and actual buying decisions remain inadequately understood. Therefore, using the Elaboration Likelihood Model, this study examines the impact of wine influencers’ characteristics on consumers’ attitudes, purchase intentions, and actual buying behaviour. A survey of 404 social media users was conducted using a structured questionnaire. The structural equation modelling analysis found that perceived credibility impacts attitudes toward influencers but not recommended brands. However, perceived expertise and trust strongly predict attitudes toward influencers and brands. Congruence has no significant impact. Attitudes toward influencers and brands positively correlate with purchase intention, which, in turn, leads to actual purchases. These insights offer marketers a roadmap for leveraging wine influencers’ characteristics to impact consumer behaviour effectively.
Wine law, sustainable innovation and the emergence of a wine constitution
Authors: Reinhardt Tilman , Ambrogio Yasmine , Springer Laura , Tafel Maximilian
Published: November 2024

Innovation is essential for addressing the current challenges of the wine sector and ensuring its sustainable future. Law plays a pivotal role in fostering and disseminating innovation. At the same time, innovations can present legislators with significant challenges and cause legal disruption. This paper evaluates the innovativeness of European Wine Law in light of the ongoing sustainability transformation. The focus of EU regulations is wine quality and authenticity, mainly through the protection of Geographical Indications (GIs). In Regulation (EU) 2021/2117, the EU legislator recently introduced new rules on fungus-resistant grape varieties, de-alcoholised products, and digital labelling. We describe the effects of these rules on the respective innovation systems and assess how, vice versa, these innovations exert disruptive pressure on wine law. While the legal framework shows remarkable flexibility, a reconfiguration seems necessary at the level of GIs. The sustainability transformation implies an openness to innovation even for traditional producers. Regulatory Sandboxes in GI product specifications could allow for more experimentation without compromising heritage. A wine constitution could guide the transformation towards a more resilient and sustainable wine system.
Exploring blockchain adoption in the italian wine industry: insights from a multiple case study
Authors: Cricelli Livio , Mauriello Roberto , Strazzullo Serena
Published: November 2024

Modern blockchain-based product tracking systems have the potential to revolutionize the agrifood industry, ensuring transparency and accountability. The need to comply with stringent regulations and contrast frauds makes applications in the wine industry particularly relevant. However, recent studies suggest that the adoption of blockchain in the wine industry presents unique complexities and opportunities. Adopting a multiple case study approach, this paper uses data from 16 SMEs in the Italian wine industry to provide a comprehensive overview of the drivers and challenges of blockchain adoption in the wine industry. Furthermore, this study extends the literature by identifying the key requirements of a blockchain system that meets the needs of SMEs in the wine industry. This study contributes to the literature through the identification of 8 fundamental challenges and drivers of blockchain adoption in the wine industry, including companies’ lack of familiarity with the technology, lack of technological skills, the importance of management vision and partnerships with technology providers. The results also clearly highlight the need to develop blockchain systems combining supply chain management and marketing objectives. Finally, this study provides useful practical implications, which can guide wineries and governments to promote the adoption of blockchain in the wine industry.
TRAUMATISMO CRANIOENCEFÁLICO NO BRASIL: UMA ANÁLISE EPIDEMIOLÓGICA
Authors: Oliveira Araújo Lara Vitória , Araújo dos Santos Rickelven , Medeiros de Sousa Ferreira Lais Helena , Povoa Ferreira Gilcimara , Sousa Araújo Maurício Wesley , Moraes de Sousa Larissa , Vieira de Carvalho Ana Paula , Do Lago Brandão Lorena Caroline , Araújo dos Santos Aline Keuly , De Sousa Costa Delciane , Reis Holanda João Vitor , Nonato da Cunha Santos Charlles
Published: November 2024

Este artigo tem por objetivo analisar e sintetizar os dados epidemiológicos relacionados ao Traumatismo Cranioencefálico (TCE), abordando as tendências de incidência, prevalência, fatores de risco. Foram utilizados como motores de busca os indexados Biblioteca Virtual em Saúde (BVS) com as seguintes bases de dados: Literatura Latino-Americana em Ciências da Saúde (LILACS), Base de Dados em Enfermagem (BDENF), Medical Literature Analysis and Retrieval System Online (Medline) para seleção dos artigos, através dos unitermos “Traumatismo Craniocerebral, Epidemiologia e Saúde”. Conclui-se a importância de políticas públicas abrangentes e ações preventivas para reduzir a incidência de TCE e melhorar o suporte pós-tratamento para minimizar as graves consequências desta condição para a saúde pública.
EFICÁCIA DA LIPOASPIRAÇÃO MECÂNICA COMPARADA COM A ENZIMÁTICA DA PAPADA: REVISÃO DE LITERATURA
Authors: Silva Elioenay Inácia da , LIRA RAYANNE , Andrade Taysnara Ismaely de
Published: November 2024

A odontologia contemporânea tem desbravado diversas atuações, uma delas é a harmonização orofacial, que é reconhecida como uma especialidade que atua com um conjunto de procedimentos, na área que compete exclusivamente ao cirurgião dentista, sua formação atenuada em cabeça e pescoço, não se restringe somente a dentes mas toda estrutura orofacial. A procura pela estética facial tem aumentado cada vez mais. Um dos procedimentos mais requisitados melhora o contorno facial, que é a cirurgia de lipoaspiração de papada mecânica, saindo a frente dos resultados obtidos positivamente em relação a lipoaspiração de papada enzimática. Cada uma tendo suas indicações e abordagens, sendo necessário uma avaliação individualizada, levando em consideração a queixa principal e a expectativa do paciente; esclarecendo as informações, orientações pós-operatórias e os riscos que podem ser acometidos.
PERFIL DE RESISTÊNCIA ANTIMICROBIANA: RESULTADO DA VIGILÂNCIA EPIDEMIOLÓGICA DAS INFECÇÕES RELACIONADAS Á ASSISTÊNCIA A SAÚDE-IRAS DE UTI´S DE UM HOSPITAL DE REFERENCIA EM INFECTOLOGIA DE MANAUS
Authors: PORTELA DE AZEVEDO ARIMATÉIA , LEANDRO DOS SANTOS MIQUÉIAS LEANDRO , EVANGELISTA DE MOURA BLENDA
Published: November 2024

Introdução: As bactérias multirresistentes são aquelas que se tornam resistentes à ação de vários antibióticos por meio de mutações. A forma mais eficiente de quebrar a cadeia de tranmissão dessas bacterias em ambiente hospitalar é a higiene das mãos. Objetivo: Descrever o perfil de crescimento de cepas multirresistentes nas UTI´s de um hospital de referência em doenças tropicais de Manaus no período de janeiro a dezembro de 2023. Metodologia: Trata-se de um levantamento de informações secundarias existentes no banco de dados da CCIH da Fundação de Medicina Tropical Dr. Heitor Vieira Dourado-FMT/HVD. Resultados: De janeiro a dezembro de 2023 foram notificadas 60 Infecções Relacionadas a Assistência a Saude-IRAS, destas, 32 (53,3% eram Pneumonias Relacionadas a Ventilação Mecânica-PAVM, 21casos (35%) Infecção Primarias da Corrente Sanguínea relacionada ao cateter Central-IPCS E 7 (11,7%) Infecções do trato urinário Relacionadas ao Cateter vesical de demora-ITU. Quanto ao perfil de resistência, os microrganismos mais frequentes foram os Staphylococcus aureus sensível a vancomicina e oxacilina (33,3%) E Klebsiella aerogenes resistentes para carbapenêmicos (13,7%) Escherichia coli resistente a carbapenêmicos (13,7). Quanto ao perfil patológico, 45,8% dos pacientes que desenvolveram IRAS nas UTI´s eram portadores de SIDA. Conclusão: A análise do perfil microbiológico de um hospital, bem como do perfil de resistência dos microrganismos, é uma ferramenta de extrema utilidade na prevenção e combate de infecções relacionadas à assistência à saúde (IRAS).
COMPLICAÇÕES DE HIDROPSIA FETAL ASSOCIADA AO CITOMEGALOVÍRUS
Authors: MALVEZZI MARIANA , SOUZA DACROCE VICTOR , ENRIQUE GIMENES DA SILVA RICARDO , BOITO DE OLIVEIRA GIULIA , ROBERTA PEREIRA GIULIA , SOARES DE ANDRADE NICOLAU MYLENA , ALBERTO CALDEIRA BRANT CARLOS , SANDES GROSSI HELOISA , MALTA MASCARENHAS NAYANDRA , CANO LAVERDE LARYSSA , MASSI BATISTA EDUARDA , PIOLI GUARINI RHAREZA , LOPACINSKI WATANABE HELOÍSA , MORETI ANA BEATRIZ , BOITO DE OLIVEIRA MARINA , FATIMA KROKOSCZ MARTIGNON LUIZA , BOM-AMI BARROS MEES MARIA LUIZA , RUDY FERRARINI KELSON , DE ALMEIDA KULEVICZ JÉSSICA , DE PÁDUA ANA RAFAELLA , PRIETO PEREIRA MARIÉLEN EDUARDA
Published: November 2024

O citomegalovírus humano (HCMV) é um importante causador de infecções congênitas e perinatais identificadas globalmente, sendo a infecção viral transmitida intraútero mais frequente e grave entre os recém-nascidos (RN). Os achados clínicos em neonatos sintomáticos são inespecíficos, podendo cursar com petéquias e hidropisia fetal. Este trabalho tem por objetivo realizar um relato de caso clínico evidenciando um RN masculino que, ao nascimento, não chorou e não apresentou tônus muscular. O paciente apresentava cianose, mecônio, frequência cardíaca menor do que 100 bpm e, mesmo após os primeiros cuidados, não obteve melhora clínica, sendo necessário seu encaminhamento para a UTI. No oitavo dia, surgiram petéquias, e os exames laboratoriais identificaram a presença de HCMV por meio do PCR de urina. O tratamento realizado com Ganciclovir permitiu a alta UTI após 21 dias de uso. Conclui-se que a atenção aos sinais de alarme, diagnóstico precoce, manejo adequado das complicações e a aplicação oportuna do tratamento correto são fundamentais para garantir uma evolução favorável do paciente.
ANÁLISE SOBRE A COMPREENSÃO DOS PACIENTES DE UMA INSTITUIÇÃO DE ENSINO SOBRE HALITOSE
Authors: Dos Santos Corrêa Clelia Suele , Scarton Owens Sofie , Piardi Rafaela , Galafassi Daniel , Pereira Butze Juliane
Published: November 2024

Objetivos: verificar o conhecimento sobre halitose dos pacientes atendidos no Curso de Odontologia do Centro Universitário da Serra Gaúcha – FSG. Métodos: os pacientes foram avaliados através de um questionário com perguntas objetivas acerca do assunto. A análise dos dados foi realizada de forma descritiva, através de números absolutos e percentuais.  Resultados: A amostra foi composta por 81 pacientes, na sua grande maioria do gênero feminino (63%) com idade média de 50,7 anos, onde maior parte dos estudados possuem somente o ensino médio completo (32,5%). Quanto à causa do mau hálito, praticamente, metade dos entrevistados acreditam ser de origem bucal (48%) e a outra metade de origem estomacal (44%), 95% acreditam em tratamento para halitose e 58% que este deva ser realizado pelo Cirurgião-Dentista. A maioria dos pacientes acredita que a escovação dentária seja o melhor tratamento para a halitose, bem como sua higiene bucal deficiente seria sua principal causa. Conclusão:  a falta de conhecimento da população sobre a halitose é um problema significativo. Muitas pessoas não compreendem as causas, consequências e tratamentos disponíveis. O papel do Cirurgião-Dentista na informação e educação sobre halitose é fundamental, não apenas tratando a condição, mas também atuando como educadores, ajudando os pacientes a entenderem as causas e a importância de uma boa higiene bucal. Objetivos: verificar o conhecimento sobre halitose dos pacientes atendidos no Curso de Odontologia do Centro Universitário da Serra Gaúcha – FSG. Métodos: os pacientes foram avaliados através de um questionário com perguntas objetivas acerca do assunto. A análise dos dados foi realizada de forma descritiva, através de números absolutos e percentuais.  Resultados: A amostra foi composta por 81 pacientes, na sua grande maioria do gênero feminino (63%) com idade média de 50,7 anos, onde maior parte dos estudados possuem somente o ensino médio completo (32,5%). Quanto à causa do mau hálito, praticamente, metade dos entrevistados acreditam ser de origem bucal (48%) e a outra metade de origem estomacal (44%), 95% acreditam em tratamento para halitose e 58% que este deva ser realizado pelo Cirurgião-Dentista. A maioria dos pacientes acredita que a escovação dentária seja o melhor tratamento para a halitose, bem como sua higiene bucal deficiente seria sua principal causa. Conclusão:  a falta de conhecimento da população sobre a halitose é um problema significativo. Muitas pessoas não compreendem as causas, consequências e tratamentos disponíveis. O papel do Cirurgião-Dentista na informação e educação sobre halitose é fundamental, não apenas tratando a condição, mas também atuando como educadores, ajudando os pacientes a entenderem as causas e a importância de uma boa higiene bucal.
Inovasi Peningkatan Produksi Konten Media di Klik Madura
Authors: Zawiyah Sofiyatus , Qodriyah Lailatul , Walid Miftahul
Published: November 2024

"Inovasi Produksi Konten dalam Media Sosial" membahas upaya perbaikan dan peningkatan daya saing KLIK MADURA sebagai mitra media cyber lokal. Fokus penelitian melibatkan beberapa permasalahan, seperti ketidakrutinan konten harian, dan rendahnya pengenalan media. Dalam menghadapi tantangan ini, penelitian mempertimbangkan pengabdian sebelumnya, menawarkan solusi dengan memproduksi konten dan menetapkan tujuan perbaikan yang melibatkan promosi digital, pembuatan artikel rutin, dan update konten media sosial. Langkah-langkah ini didasarkan pada pemahaman mendalam terhadap mitra dan melibatkan tindakan langsung seperti turun lapangan dan kegiatan liputan. Dengan demikian, penelitian ini bertujuan untuk meningkatkan kualitas dan visibilitas KLIK MADURA di ranah media social lokal, menggambarkan pendekatan holistik terhadap inovasi produksi konten.
THE PARTHO-ROMAN RELIEFS FROM TUR ABDIN: ROCK-CUT RELIEFS OF BEGANI
Authors: Bozkurttan Ramazan , Şan Mehmet
Published: November 2024

This paper analyses the Begani rock reliefs, a crucial body of works reflecting the complex cultural and artistic interactions of the Partho-Roman period in northern Mesopotamia. The study investigates the strong links between the reliefs and Parthian and Mesopotamian artistic traditions and focuses on the iconographic elements that characterise this period, such as clothing, postures, and weapons. The analyses indicate that the Begani reliefs have common features with sculptural works from prominent artistic centres such as Edessa, Hatra and Palmyra, pointing to a broader cultural network in the region. The synthesis of local traditions in the depicted garments, including tunics and trousers, demonstrates the widespread influence of these artistic expressions across different regions. Furthermore, the paper highlights the Adiabene kingdom's role as a major regional power, which probably influenced artistic production in neighbouring principalities by evaluating the reliefs in the context of the kingdom of Adiabene. The influence of the Parthian Empire and subsequent Roman control has been recognised as crucial in shaping the region's artistic landscape. Despite the difficulties posed by the damage the reliefs suffered, which made it challenging to identify the figures, the details provide insight into the artistic transformations of the period. The results emphasise the importance of further research into the iconography of the Begani reliefs and their relationship with other regional works. This approach aims to improve our understanding of the social and religious contexts of the sculptural traditions of northern Mesopotamia and their interrelationships within the framework of artistic production in the region.
Pengaruh Pupuk Organik Limbah Jamur Merang dan Pupuk Hayati Terhadap Pertumbuhan dan Hasil Tanaman Kedelai (Glycine max L. Merril) Varietas Grobogan
Authors: Pradana Haria , Subardja Vera Oktavia , Pirngadi Kasdi
Published: November 2024

The neednutrients in the soil isimportantfor the successful growth and yield of soybean. Organic fertilizer of merang mushroom waste and types of biological fertilizers are one of the efforts to improve soil fertility and provide sufficient nutrients in the soil. The purpose of this study was to determine the effect of the interaction between organic fertilizer of merang mushroom and type of biological fertilizers on the growth and yield of soybean plants (Glycine maxL. Merril) Grobogan Variety. This research was conducted at Experimental Farm of the Campus 1 Faculty of Agriculture, Singaperbangsa University of Karawang, located in Puseurjaya Village, East Telukjambe Subdistrict, Karawang Distric, West Januari. The experiment was conducted from Januari  to April 2024. The research method was used randomized block design (RBD), factorial with two factors. The first factor was the application of organic fertilizer of merang mushroom waste (M) with 3 levels, The second factor was the application of biological fertilizer (P) with 4 levels. There were 12 treatments that will be 3 replications, so there were 36 experimental units. Each unit has 3 sampleplants. The effect of treatment was analyzed by analyzed of variance and if the F test at 5% level was significant, then DMRT (Duncan Multiple Range Test). The results showed that there where interaction between organic fertilizer of merang mushroom waste and the type of biofertilizer on the parameters of plant height  14, 21, 28, 35 and 42 days after planting (dap), number of trifoliate leaves  21, 28, 35 and 42 dap, stem diameter 42 dap, root length, root nodules, number of pods,  the number of seeds, but they were not interaction on the parameters of root wet weight, root dry weight, seed weight per 100 grains and yield of seed weight. Keywords: soybean, nutrient, organic fertilizer, biofertilizer
Variabilitas Genetik pada Beberapa Varietas Unggul Baru Padi (Oryza sativa L.) Berdasarkan Penanda Morfologi Biji
Authors: Ardani Hanna Qotrunnada , Syafii Muhammad , Azizah Elia , Susanto Untung
Published: November 2024

Rice (Oryza sativa L.) is known to have a very diverse genetic diversity. The target of rice variety improvement is to produce new varieties that have superior traits in accordance with the development objectives in each typological region. This study aims to determine the level of similarity formed in a number of new superior varieties. The method used is descriptive experimental, with 51 treatments, namely new superior varieties, repeated 3 times so that there are 132 experimental units. Each agronomic character observation data was analyzed by clustering using the UPGMA method. The analysis used NTSYS 2.02i and 2.11a software. The results showed that the genetic variability of 51 new superior varieties of rice (Oryza sativa L.) has a similarity coefficient value of 0.81 based on clustering analysis. This shows a high level of similarity of genetic variability, however, the clustering results form 5 main groups with genetic distances ranging from 0.0000 - 0.5593.  Keywords: genetic variability, seed morphology, new improved varieties, clustering.
Respon Pertumbuhan Tanaman Pakcoy (Brassica rapa L.) Varietas Nauli F1 Melalui Pemberian Pupuk Kandang Sapi dan NPK 16-16-16
Authors: Hulu Nidar Mawati , Zulfida Ida , Dewi Dora Silvia
Published: November 2024

Pakcoy (Brassica rapa L.) is a type of vegetable plant that belongs to the Brassicaceae family. Pakcoy plants originate from China and have been cultivated since the 5th century widely in southern China and central China and Taiwan. The purpose of this study was to determine the response of growth and yield of pakcoy mustard plants (Brassica rapa L.) through the provision of organic fertilizer Cow Manure and Inorganic fertilizer NPK 16-16-16. This study used a Randomized Block Design (RAK), consisting of 2 factors and 4 levels with 3 Replications. Where the first factor is Cow Manure (P) with 4 levels, namely = P0 Control P1: (1 kg/plot), P2: (2 kg/plot), P3: (3 kg/plot). And the second factor is NPK 16-16-16 fertilizer with 4 levels, namely: N0: control, N1: (25 grams/plot), N2: (50 grams/plot), N3: (75 grams/plot). The parameters observed are: plant height (cm), number of leaves (strands). Analysis of variance with Analysis of variance (Anova), continued with DMRT test at 0.05% level if there is a real treatment. The average height of pak choy plants that gave the highest value was in treatment P2 = 19.15, N0 = 17.72 In the 28th observation hst, the number of leaves in treatment P1 = 114.21, N2 = 12.49. Keywords: pakcoy, cow manure, NPK 16-16-16.
Pengaruh Aplikasi Pupuk NPK Terhadap Pertumbuhan dan Produksi Tanaman Wortel (Daucus carota L.)
Authors: Giawa Yunus Yaaro , Zulfida Ida , Harahap Lutfi Henderlan
Published: November 2024

Indonesia is one of the tropical countries that has a variety of plants including vegetables and fruits. One that has the largest production is carrots (Daucus carota L.). Carrots are a type of shrub-shaped vegetable plant, which grows upright with a height of 30-100 cm or more. Carrots (Daucus carota L.) are a tuberous vegetable type plant that is usually reddish yellow or yellowish orange with a wood-like texture. The edible part of a carrot is the bulb or root. The plant stores food reserves in the bulb. The stem is short, has a taproot that changes its shape and function into a round and elongated tuber. The skin of carrot bulbs is thin and if eaten raw, it feels crunchy and slightly sweet. Here's a picture of a carrot plant. One way to increase the yield of carrot plants is by increasing soil productivity, using the addition of NPK fertilizer. This study used a factorial randomized group design (RAK). For accuracy in this study, it was repeated 3 times. namely: NPK fertilizer (N) with 3 levels, namely: N0 = Control, N1 = 15 g/plot, and N2 = 25 g/plot. From the ANOVA test results, the variance of treatments that have a significant effect is continued with the Duncan DMRT test at the 5% level. The results of the ANOVA test showed that the effect of NPK fertilizer treatment on plant height 21 hst and 28 hst, the number of leaves had no significant effect, but the observation of the diameter of the base of the tuber, the fresh weight of the plant per sample and the fresh weight of the plant per plot had a significant effect.  Keywords: NPK fertilizer, NPK dosage, and carrot plants
Respon Pertumbuhan dan Produksi Bawang Merah (Allium ascalonium L.) Terhadap Pupuk NPK
Authors: Laia Jeprianus , Harahap Rahmaniah , Miyarnis Miyarnis
Published: November 2024

North Sumatra is shallots. Shallot (Allium ascolonicum L.) is a horticulture that has many benefits for people's lives, both from economic value and nutritional content, so that shallot production increases every year and is proven based on BPS (Central Statistics Agency) for the last 5 years. The effort needed to meet the needs of shallot production is to increase soil productivity, using the addition of NPK fertilizer. This study used factorial randomized group design (RAK). For accuracy in this study, it was repeated 3 times. namely: NPK fertilizer (N) with 3 levels, namely: N0 = Control, N1 = 5 g/plant, and N2 = 10 g/plant. The results of the Anova Variance test showed that the response of NPK fertilizer treatment to plant height 3 mst, 4 mst, 5 mst, 6 mst and wet weight of tubers per plot (g) had a significant effect, but the observation of the number of tubers per sample plant (tubers), and the diameter of tubers per sample (mm) had no significant effect.  Keywords: NPK fertilizer, NPK dosage, and shallots
Supportive Strategies in Teaching Summary Writing to Secondary Level ESL/EFL Learners
Authors: Ali Shahid Mazhar , Hafiz Muhammad Suleman , Hussain Zahoor , Mohmed Ibrahim Abdelgawi Abdelsalam
Published: November 2024

The entire aim of writing this paper is to discuss and explore the effectiveness of various supporting strategies/ techniques in order to teach summary writing to secondary school students. As we know that English has gained a global position in terms of its usage therefore, the teaching methodology should also be simplified. In English language teaching, writing is considered as the toughest and hardest skill to overcome, as it is not an easy skill that could be learned without much practice and effort. Similarly, writing a summary is also a challenging task in written communication. A summary expresses an idea, feeling and opinion in writing, but in a concise form. Students are often confused as it is a hard task for them to write a summary of a given text in the class at high school level. They find teacher as an absolute and ultimate source to lead them to follow the path of summary writing. A teacher can provide them simple and easy strategies/techniques for summary writing. A teacher can introduce them different supportive, simple strategies to write a good summary e.g. 1. He may give his students a short text to read silently, 2. Teacher can explain an organizer for summarizing a text, 3. He can ask the students to make points for summary writing in their own words seeking help from the text and from the organizer, 4. Finally they can produce a summary with the help of these points. We can conclude that simple, clear and easy strategies /techniques in summary writing can help the students in improving their writing. These strategies may also prove helpful for teachers in the teaching of writing a summary effectively and efficiently.
Efektivitas Terapi Teh Daun Kelor dan Teh Hijau Terhadap Penurunan Kadar Gula Darah Sewaktu (GDS) pada Penderita Diabetes Melitus di Puskesmas Palimanan Kabupaten Cirebon
Authors: Rakhmawati Arifah , Sri Futriani Elfira
Published: November 2024

Diabetes melitus adalah kumpulan gangguan metabolik yang ditandai dengan peningkatan kadar gula darah (hiperglikemia) yang disebabkan oleh gangguan dalam sekresi insulin, fungsi insulin, atau keduanya. Penatalaksanaan diabetes melitus tidak hanya mencakup terapi farmakologi, tetapi juga melibatkan terapi non-farmakologi, termasuk terapi komplementer. Terapi komplementer yang dapat diberikan yaitu terapi teh daun kelor dan terapi teh hijau. Tujuan penelitian ini adalah untuk mengetahui efektivitas terapi teh daun kelor dan teh hijau terhadap penurunan kadar gula darah sewaktu (GDS) pada penderita diabetes melitus di Puskesmas Palimanan Kabupaten Cirebon tahun 2024. Penelitian ini menggunakan quasy experimental dengan Non Equivalent Control Group Design. Pengambilan sampel menggunakan purposive sampling dengan sampel 48 responden. Pengambilan data menggunakan lembar observasi dan kuesioner. Analisa data dilakukan dengan analisis univariat dan analisis bivariat menggunakan uji paired t-test dan uji independent t-test. Hasil penelitian menunjukkan rerata kadar gula darah sebelum diberikan teh 246.04 mg/dl, sesudah 188.50 mg/dl sedangkan pada teh hijau didapatkan rerata sebelum 247,92 mg/dl, sesudah 200.08 mg/dl. Hasil uji statistik sesudah intervensi menggunakan independet t-test menunjukkan nilai p = 0.004 (p<0.05). Kesimpulan penelitian ini adalah terdapat perbedaan efektifitas diantara keduanya, pemberian terapi teh daun kelor lebih efektif dibandingkan teh hijau dengan masing-masing rerata 57.542 dan 47.833.
Hubungan Paritas, Usia dan Pendidikan Ibu Hamil Trimester III dengan Tingkat Kecemasan dalam Menghadapi Masa Menjelang Persalinan di Puskesmas Petir Kabupaten Serang Tahun 2020
Authors: Hasrida  , Marina
Published: November 2024

Tujuan: Mengidentifikasi Kecemasan pada ibu hamil trimester III yang disebabkan oleh rasa takut menghadapi persalinan yang disebabkan oleh beberapa faktor antara lain paritas, umur dan pendidikan.  Untuk mengetahui hubungan paritas, umur dan pendidikan ibu hamil trimester III dengan tingkat kecemasan menghadapi masa menjelang persalinan di Puskesmas Petir Kabupaten Serang Tahun 2020. Metode: Artikel ini bersifat kuantitatif analitik dengan desain cross sectional. Sampel dalam penelitian ini adalah 55 responden ibu hamil trimester III dengan menggunakan teknik total sampling. Instrumen penelitian menggunakan kuesioner. Data primer dianalisis dengan menggunakan uji kuadrat. Hasil: Hasil analisis univariat menunjukkan mayoritas ibu hamil trimester III mempunyai paritas risiko rendah 65,5%, usia risiko rendah 67,3%, pendidikan rendah 63,6%, dan tingkat kecemasan sedang 60,0%. Hasil analisis bivariat menunjukkan terdapat hubungan yang signifikan antara paritas (p value = 0,018), umur (p value = 0,006) dan pendidikan (p value = 0,002) dengan tingkat kecemasan ibu hamil trimester III dalam menghadapi periode mendekati persalinan. Kesimpulan: paritas, umur dan pendidikan berhubungan dengan tingkat kecemasan ibu hamil trimester III dalam menghadapi masa mendekati persalinan. Ibu hamil diharapkan dapat memanfaatkan pelayanan kesehatan untuk mengurangi rasa cemas menjelang melahirkan, sehingga pada saat persalinan ibu akan lebih tenang.
Faktor yang Berhubungan dengan Kejadian Stunting pada Balita
Authors: Mariyani
Published: November 2024

Stunting merupakan penggambaran dari status gizi kurang yang bersifat kronik pada masa pertumbuhan dan perkembangan sejak awal kehidupan. Banyak faktor yang dapat menyebabkan terjadinya stunting pada balita seperti karakteristik balita maupun faktor sosial ekonomi. Tujuan dari penelitian ini adalah mengetahui faktor yang berhubungan dengan kejadian stunting pada balita. Penelitian ini merupakan penelitian observasional analitik dengan desain kasus kontrol yang dilakukan di wilayah kerja Puskesmas Tanah Kali Kedinding, Surabaya. Sampel yang diambil sebanyak 34 balita untuk masing-masing kelompok kasus maupun kontrol dengan teknik simple random sampling. Analisis data menggunakan uji Chi-Square dan Fisher Exact. Hasil penelitian menunjukkan bahwa panjang badan lahir yang rendah (OR=4,091; CI=1,162-14,397), balita yang tidak mendapatkan ASI Eksklusif (OR=4,643; CI=1,328-16,233), pendapatan keluarga yang rendah (OR=3,250; CI=1,150-9,187), pendidikan ibu yang rendah (OR=3,378; CI=1,246-9,157), dan pengetahuan gizi ibu yang kurang (OR=3,877; CI=1,410-10,658) merupakan faktor yang berhubungan dengan kejadian stunting pada balita. Terdapat hubungan antara panjang badan lahir balita, riwayat ASI eksklusif, pendapatan keluarga, pendidikan ibu dan pengetahuan gizi ibu terhadap kejadian stunting pada balita. Perlunya program yang terintegrasi dan multisektoral untuk meningkatkan pendapatan keluarga, pendidikan ibu, pengetahuan gizi ibu dan pemberian ASI eksklusif untuk mengurangi kejadian stunting.