bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDY OF THE ANTIDEPRESSANT ACTIVITY OF THE ETHANOLIC EXTRACT OF THE LEAVES OF MORINGA OLEIFERA L. (EEMO) ON ALBINO MICE
Authors: KAUSHIK SHIPRA , KAUSHIK SHOBHIT , RAI JAYANT
Published: February 2023

Objectives: The aim of the study is to evaluate the antidepressant activity of the ethanolic extract of the leaves of Moringa oleifera L. (EEMO) on albino mice.
Methods: The anti-depressant activity was evaluated using forced swimming test (FST) and tail suspension test (TST). Healthy albino mice were individually forced to swim inside a vertical glass cylinder. Climbing, swimming, and immobility were tested and recorded. In TST, mice were suspended on a string held by a metal stand, and immobility time was recorded.
Results: In both FST and TST, it was seen that immobility time decreased with increase in the dose of EEMO.
Conclusion: Ethanolic extract of M. oleifera possess anti-depressant activity in a dose dependent manner.
BICKERSTAFF BRAINSTEM ENCEPHALITIS AND MILLER FISHER SYNDROME – VARIANT OF GUILLAIN-BARRÉ SYNDROME A SPECTRUM OF CLINICAL MANIFESTATION OF SAME DISEASE
Authors: KULSHRESTHA MANISH , KULSHRESTHA ANJALI
Published: February 2023

Guillain-Barré syndrome (GBS) and its variants are parainfectious (2/3 cases) neurological illness involving the lower motor neuron but they can also involve central nervous system (CNS). Bickerstaff brainstem encephalitis (BBE) and Miller Fisher syndrome (MFS) are the two variants of GBS with CNS involvement. The present case series highlights the variable presentation and laboratory findings in BBE and MFS, which may help clinicians in early recognition and timely management of the condition.
A inovação em serviços de informação nas bibliotecas: o TikTok como proposta de posicionamento digital
Authors: Fonseca Diego Leonardo de Souza , Fonseca Maria Gabriella Flores Severo
Published: February 2023

El objetivo de este estudio es proponer estrategias de uso para lograr un mayor compromiso de las bibliotecas en la red social TikTok, observando esta plataforma como una herramienta potencialmente innovadora. Se trata de un estudio basado en una investigación descriptiva y exploratoria con un enfoque cualitativo, realizándose un sondeo de informes de investigación y experiencias en bases de datos científicas sobre el uso de TikTok en bibliotecas, así como la recopilación de perfiles en la propia red social. Los resultados observados identificaron un escenario aún en expansión de las bibliotecas en el uso estratégico de TikTok específicamente dirigido al marketing y al posicionamiento digital. Dicho esto, se elaboró una propuesta de planificación para el uso estratégico de TikTok enfocada a la mejora del posicionamiento digital de las bibliotecas en la red social, basada en tres aspectos: buenas prácticas de uso, tácticas de marketing de influencia y herramientas de apoyo digital. Se concluyó que TikTok ofrece un abanico de posibilidades para la innovación en los medios sociales, siendo necesario que las bibliotecas comiencen a utilizar esta plataforma como recurso para la optimización de su posicionamiento digital en relación con el usuario, especialmente ante los cambios sociales y tecnológicos que se están remodelando a partir de la pandemia del Covid-19.
Current State of the Muslim Ummah of the Chechen Republic
Authors: Osmaev A. D.
Published: February 2023

Chechens are the largest population in the North Caucasus and the sixth largest in the Russian Federation (right after Russians, Ukrainians, Tatars, Bashkirs, Chuvashs). According to official data, there are currently 1,516,387 people living in the republic, of whom 1,206,551 are Chechens. A large number of Chechens live in European countries. Although there are no exact official figures, various researchers place the figure between 150,000 and 300,000, with most Chechens living in France, Belgium, Norway, Austria, Poland, and Germany. The Middle Eastern and Turkish diasporas of Chechens are not so numerous, but they have a longer period of residence there, as they mostly consist of the descendants of immigrants from the second half of the 19th century. Chechens are Sunni of Shafi‘i Madhab, adhere to the Naqshbandi and Qadiri tariqats, which are divided into fraternities called virds, and according to various estimates, there are up to 34 of them in the republic. The Nogays and Kumyks living in the Chechen Republic belong to the Hanafi madhab, while the Avars (Chamalals) of the mountain village of Kenkhi (population over 1500) belong to the Shafi‘i madhab.
Hanafi Mazhab: the History of Formation, Classifi cation, and Review of the Main Sources
Authors: Gaynutdin R. I. , Baishev R. I.
Published: February 2023

This publication describes the history of the formation and development of the Hanafi theological and legal school. It analyzes the influence of the companions of the Prophet Muhammad on the development of basic methodological principles by the eponym of this school — Abu Hanifa. The paper presents the generally accepted classification of the jurists of this madhhab, describes their role in the formation of the Hanafi tradition. It also provides a brief overview of the main classical and modern works on Hanafi law, including domestic theologians — Sh. Marjani, A. Kursavi, G. Barudi and A.-H. Maksudi, as well as translations of classical works into Russian.
Translations of the Qurʼān into Chinese: Peculiarities of the Names of Suras
Authors: Bernikova O. A. , Nikitina E. A.
Published: February 2023

The paper discusses some peculiarities of translating the names of suras of the Qurʼān into Chinese based on the study of the most common Chinese translation made in the second half of the last century by the Muslim intellectual Muhammad Ma Jian. The work examines suras possessing the most significant discrepancies between the original Arabic names and the corresponding Chinese equivalents. The study is accompanied by commentary on the potential reasons for these variations while taking into account factors of an ethnocultural and linguistic nature. In a number of cases, comparisons with translations of the Qurʼān into Russian are also provided. The interdisciplinary nature of the work is manifested in the application of methods of source study, historical and philological, and comparative analysis. Having researched the main milestones in the history of translations of the Qurʼān into Chinese in the context of the spread of Islam in China, the authors come to the conclusion that the peculiarities of the translation of the names of suras into Chinese are largely due to the history of their occurrence and the variability of the original names since the written record of the Holy Text. At the same time, Muhammad Ma Jian’s belonging to the Hui community and Chinese traditions and customs also influenced the process of choosing equivalents. Obviously, the search for correspondences relied on the synthesis of methods based on the analysis of different variants of the names of suras and the need for ethnocultural adaptation of individual concepts in order to ensure the adequate perception of certain concepts by the inhabitants of the China. The problems of translating the Qurʼān into Chinese are largely related to the typological difference between the two linguistic systems. In this regard, the analysis of the translations of the names of suras of the Qurʼān into Chinese seems to be the most optimal starting point for the study of this topic.
Muslim Employees of Posolskĳ Prikaz: Between Islam and Christian Orthodoxy
Authors: Belyakov A. V.
Published: February 2023

Due to the necessity for continuous contacts between the Russian principalities, the Golden Horde khans, and the khan’s administration, in the 13th century specific structures designed to serve them were created. They partly survived even after the Moscow principality gained independence and were engaged in organizing diplomatic missions with neighboring states. The most stable element of these services were the Tatar servicemen of the Grand Prince. In the earliest period they were called Ordyncy [members of the Horde] and Delyus. With the creation of the Posolskĳ Prikaz, they become servant Tatars and Cossack inhabitants of a stanitsas of the Foreign Ministry and initially interpreters and translators from oriental languages were recruited among them. The status of the Ordyncy as personal servants of the Grand Prince allowed them to enjoy certain privileges, in particular, they had mosques in the places of their concentrated residing. Archival documents contain sporadic mentions of their imams. At first, the number of such Tatars could reach several hundreds. However, their number gradually decreased. Tatars lost the privilege to be the interpreters and translators of the Foreign Ministry, although descendants of the translators of the Posolskĳ Prikaz, who in some cases remained Muslims, continued to serve in the Collegium and the Ministry of Foreign Affairs. At the same time one can trace their mosque in the Zamoskvorechye District of Moscow as far back as the 18th century.
How resilience innovations in food supply chains are revolutionizing logistics, wholesale trade, and farm services in developing countries
Authors: Reardon Thomas , Vos Rob
Published: February 2023

Developing country food supply chains have been pummeled by a series (and often a confluence) of shocks over the past several decades, including the Russia-Ukraine war, COVID-19, climate shocks from hurricanes to floods to droughts, animal and plant diseases, an intensification of road banditry and local conflicts, and overlaying all these, deep transformation in markets themselves with new requirements for quality and food safety. Yet supply chains have been largely resilient, adapting and bouncing back in surprising ways. We show that this has often involves deep ‘pivoting’ by one segment or one value chain, and ‘co-pivoting’ by another to facilitate the former’s pivot. We present a conceptual framework and then illustrate with a variety of examples from Africa and Asia, such as pivoting toward e-commerce by Asian retailers and co-pivoting by delivery intermediaries; pivoting toward quality horticultural production by African and Asian farmers and co-pivoting by mobile outsource services for farming and marketing; and building of redundant ports to protect rice milling operations from climate shocks in Asia by agribusiness and logistic firms. The paper provides implications for policy to facilitate these adaptions and for resilience strategies of agribusiness firms.
Differential expression of type I interferon and inflammatory genes in SARS-CoV-2 infected patients treated with monoclonal antibodies
Authors: Ceccarelli Giancarlo , Maddaloni Luca , Santinelli Letizia , Bugani Ginevra , Cacciola Elio Gentilini , Lazzaro Alessandro , Lofaro Chiara M. , Caiazzo Sara , Frasca Federica , Fracella Matteo , Ajassa Camilla , Leanza Cristiana , Napoli Anna , Cinti Lilia , Gaeta Aurelia , Antonelli Guido , Mastroianni Claudio , scagnolari carolina , D'Ettorre Gabriella
Published: February 2023

Considering the efficacy of monoclonal antibodies (mAbs) directed
against the Spike (S) protein of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) in reducing disease severity, the aim of this
study was to investigate the innate immune response before and after
mAbs treatment in 72 vaccinated and 31 unvaccinated SARS-CoV-2 patients.
Type I interferon (IFN-I) signature and cytokines genes were evaluated
by real time RT-PCR. The vaccinated patients had increased negative rate
of SARS-CoV-2 RT/real-time PCR tests as compared to unvaccinated ones
after mAbs treatment. Unvaccinated patients but also those that resulted
negative for serum anti-S antibodies despite vaccination had lower IFN-I
and higher IFN-I related genes and cytokines mRNAs levels as compared to
vaccinated individuals before mAbs. In addition, patients with low
anti-S antibody titer showed immune genes expression levels between
those found in negative and patients with high titer of anti-S
antibodies. Changes in IFN-I pathway and cytokines levels were observed
in unvaccinated patients after mAbs treatment, while the expression of
most of the type I IFN genes and cytokines analysed, except for ISGs and
IL-10 mRNAs, remained unchanged vaccinated patients. These data suggest
that mAbs treatment is associated to a different virological and
immunological response in SARS-CoV-2 infected patients according to
their vaccination status and related anti-S antibodies titers.
Trilobatin attenuates cerebral ischemia/reperfusion-induced blood-brain-barrier dysfunction by targeting MMP9: The legend of a food additive
Authors: Feng Linying , Li Yeli , Lin Mu , Xie Dianyou , Luo Yunmei , He Zhi-Xu , Gong Qihai , yizhun zhu , Gao Jianmei
Published: February 2023

Background and Purpose: Blood-brain barrier (BBB) breakdown is one of
the most crucial pathological changes of cerebral ischemia-reperfusion
(I/R) injury. Trilobatin (TLB), a naturally occurring food additive,
exerts neuroprotective effect against cerebral I/R injury as
demonstrated in our previous study. This study was designed to
investigate the effect of TLB on disruption of BBB after cerebral I/R
injury. Experimental Approach: Rats with focal cerebral ischemia caused
by transient middle cerebral artery occlusion (MCAO) and brain
microvascular endothelial cells along with human astrocytes to mimic
blood brain barrier (BBB) injury caused by oxygen and glucose
deprivation (OGD) followed by reoxygenation (OGD/R). Key results: The
results showed that TLB effectively maintained the integrity of BBB and
inhibited neuronal loss following cerebral I/R challenge. Furthermore,
TLB dramatically increased tight junction proteins including ZO-1,
occludin and claudin 5, as well as decreased the levels of
apolipoprotein E (APOE) 4, cyclophilin A (CypA), and phosphorylated
nuclear factor kappa B (NF-κB), thereby reduced proinflammatory
cytokines. In addition, TLB also decreased Bax/Bcl-2 ratio and
cleaved-caspase 3 level along with reduced the number of apoptotic
neurons. Intriguingly, molecular docking and transcriptomics predicted
MMP9 was a prominent gene evoked by TLB treatment. Furthermore, the
protective effect of TLB on OGD/R-induced the loss of BBB integrity in
human brain microvascular endothelial cell and astrocyte co-cultures in
vitro was markedly reinforced by knockdown of MMP9. Conclusions and
implications: Our findings reveal a novel property of TLB: saving BBB
disruption following cerebral I/R via targeting MMP9 and inhibiting
APOE4/CypA/NF-κB axis.
Loganin exerts antidepressant-like effects via Sigma-1R- and BDNF-dependent mechanisms
Authors: Xia Cong-Yuan , Wang Yu-Ming , Wang Man-Ni , Guo Yu-Xuan , Lian Wen-Wen , Yan Yu , Ma Bing-Zhi , Xu Jie-Kun , He Jun , Zhang Weiku
Published: February 2023

BACKGROUND AND PURPOSE Sigma-1 receptor (Sigma-1R), a chaperone protein
with the ability to activate brain-derived neurotrophic factor (BDNF)
signaling, has been connected with antidepressant action. Our previous
study indicated that loganin has antidepressant-like effects. This study
aimed to investigate whether loganin exerts antidepressant-like effects
via Sigma-1R/BDNF signaling. EXPERIMENTAL APPROACH We established rat
model of depression using chronic unpredictable stress (CUS). Sucrose
preference test (SPT) and open field test (OFT) were used to evaluate
the antidepressant-like effects of loganin. Then, we assessed the
changes of BDNF signaling, synaptic plasticity and neurogenesis in
hippocampus using western blot and immunohistochemical analysis. To
confirm the role of Sigma-1R and BDNF in loganin-induced
antidepressant-like effects, BD1047 and ANA-12 were used to block
Sigma-1R and BDNF, respectively. KEY RESULTS Loganin improved
depressive-like behaviors of rats in the SPT and OFT.
Antidepressant-like effects of loganin in the SPT occur at day 6, which
was faster than fluoxetine. Mechanismly, loganin effectively restored
CUS-induced decrease in BDNF, pERK/1/2, PSD-95 and DCX in the
hippocampus. Blockage of BDNF signaling with ANA-12 reversed the
antidepressant-like effects of loganin. Moreover, loganin exhibited a
binding affinity with Sigma-1R, as indicated by molecular docking.
Importantly, BD1047 diminished loganin-induced improvement of rat
behaviors as well as activation of hippocampal BDNF signaling.
CONCLUSIONS AND IMPLICATIONS In conclusion, loganin exerts
antidepressant-like effects by improving synaptic plasticity and
neurogenesis in the hippocampus dependent on Sigma-1R/BDNF signaling.
Awareness and acceptance of HPV vaccine for condyloma acuminata (CA) among college students without sexual experience ——Vaccine prevention of CA before happen
Authors: Xuqi-Ren * , Peng Min , Shao Qingjing , Ke Wujian , Zou Huachun , Sang Hong
Published: February 2023

Background. Sexual transmission of human papillomavirus (HPV)
types 6 and 11 causes 90% of condyloma acuminata (CA) and the
prevalence of CA in the younger generation is not low. Human
papillomavirus vaccines containing types 6 and 11 are highly effective
in preventing condyloma acuminatum transmission. By getting immunized
promptly, college students who have not had sexual experience as a
catch-up group can minimize the potential emotional and financial stress
of CA. However, no comprehensive research has been undertaken on the
views of this population about the CA vaccination. Methods.
This study aimed to examine HPV knowledge and CA vaccination acceptance
among college students without sexual experience in Guangdong, China. We
used WeChat web-based questionnaires to conduct a cross-sectional survey
of respondents. College students identified as having never had sexual
relations were maintained, and 2,139 valid questionnaires were
ultimately collected. Results. Knowledge of CA (26.2%) and HPV
(18.8%) was poor among college students who had never engaged in sexual
activity, as was the vaccination rate (2.9%). However, acceptance of
the vaccine was relatively high (54.8%). More respondents received the
CA vaccine if they were full-time students (OR = 1.962), had heard of CA
(OR = 1.505), had actively learned about CA (OR = 1.812), considered the
vaccine safe (OR = 2.310), and believed it was successful in preventing
CA (OR = 3.925). Conclusions. Overall, this population has
limited knowledge about the CA and HPV vaccines. To protect young
people’s health and lessen the disease burden, society should pay more
attention to CA and HPV vaccination education.
Pet Dogs Succeed Where Human Companions Fail: The Presence of Pet Dogs Reduces Pain
Authors: Mauersberger Heidi , Springer Anne , Fotopoulou Aikaterini , Blaison Christophe , Hess Ursula
Published: February 2023

Social support from family and friends, albeit associated with
beneficial health effects, does not always help to cope with pain. This
may be because humans elicit mixed expectations of social support and
evaluative judgment. The present studies aimed to test whether pet dogs
are a more beneficial source of support in a painful situation than
human companions, because they are not evaluative. For this, 74 and then
50 women completed a cold-pressor task either in the presence of their
own or an unfamiliar pet dog, a friend or an unknown human companion, or
alone. In both studies, participants reported less pain and exhibited
less pain behavior in dogs’ compared to human companions’ presence.
Furthermore, reactions to pain were moderated by attitudes towards dogs
in study 2. This suggests that pet dogs may help individuals to cope
with painful situations, especially if the individual in pain generally
feels affectionate towards dogs.
Coronary Artery Bypass Grafting complicated by post-operative coronavirus infection – two similar presentations with dissimilar outcomes
Authors:   University of Louisville School of Medicine, Louisville, KY, USA, Redding Alexis , Samanapally Harideep ,   Division of Infectious Diseases, University of Louisville, Louisville, KY, USA, Udoh Mike O. ,   University of Louisville School of Medicine, Louisville, KY, USA
Published: February 2023

Patients diagnosed with COVID-19 infection undergoing surgical procedures have been reported to have increased post-operative complications and mortality. These findings are important when considering cardiac surgical procedures, specifically coronary artery bypass grafting (CABG) during this pandemic, since the Society of Thoracic Surgeons (STS) describes most of these operations as ‘urgent’. In addition, the majority of cardiac surgical patients are at increased risk of infection and death with COVID-19, as they are frequently of old age, obese, hypertensive, and diabetic, with severe cardiac or pulmonary diseases. This case series describes the clinical course following a CABG procedure in two patients that went on to develop COVID-19 infection post-operatively. We aim to illustrate the similarities in clinical presentation, but differences in eventual outcomes for both patients and hypothesize the reasons for the differences.
A Review of Literature and Experimental Evidence on Fraud Motivation: Differentiating Incentive and Pressure
Authors: Knisley Robert J. , Lin Hui
Published: February 2023

This study reviews academic and professional literature on the two types of fraud motivation: incentive and pressure, and provides an in-depth analysis to investigate and differentiate incentive and pressure. The evolution of the professional standards on fraud reveals the need to differentiate incentive and pressure to mitigate fraud. A comprehensive review of academic research uncovers a plethora of fraud research that has studied incentive and pressure either discretely or without differentiation. Few studies have focused on examining and comparing them simultaneously. Theoretically grounded in the fraud triangle and motivation literature, this study synthesizes prior research on incentive and pressure, analyzes the differences by levels of autonomy and regulation. An experiment was conducted and results reveal that incentive and pressure differ in their role in influencing fraudulent intention. Incentive appears to be stronger in influencing fraud intention than pressure. We present the research implications and outline an agenda for future research.
Proinsulin–to–C-Peptide Ratio as a Marker of β-Cell Function in African American and European American Adults
Authors: Couch Catharine A. , Piccinini Francesca , Fowler Lauren A. , Garvey W. Timothy , Gower Barbara A.
Published: February 2023

OBJECTIVE

The primary purpose of the current study was to test the hypothesis that the proinsulin–to–C-peptide (PI-to-CP) ratio, as an index of proinsulin secretion, would be higher and associated with indices of β-cell function in African American adults relative to European American adults without type 2 diabetes.

RESEARCH DESIGN AND METHODS

Participants were 114 African American and European American adult men and women. A 2-h oral glucose tolerance test was conducted to measure glucose, insulin, C-peptide, and proinsulin and derive indices of β-cell response to glucose. The Matsuda index was calculated as a measure of insulin sensitivity. The disposition index (DI), the product of insulin sensitivity and β-cell response, was calculated for each phase of β-cell responsivity. Pearson correlations were used to investigate the relationship of the PI-to-CP ratio with each phase of β-cell response (basal, Φb; dynamic, Φd; static, Φs; total, Φtot), disposition indices (DId, DIs, DItot), and insulin sensitivity. Multiple linear regression analysis was used to evaluate independent contributions of race, BMI, and glucose tolerance status on PI-to-CP levels before and after adjustment for insulin sensitivity.

RESULTS

African American participants had higher fasting and 2-h PI-to-CP ratios. The fasting PI-to-CP ratio was positively associated with Φb, and the fasting PI-to-CP ratio and 2-h PI-to-CP ratio were inversely associated with DId and insulin sensitivity only in African American participants.

CONCLUSIONS

The PI-to-CP ratio could be useful in identifying African American individuals at highest risk for β-cell dysfunction and ultimately type 2 diabetes.
Safety and Efficacy of the Omnipod 5 Automated Insulin Delivery System in Adults With Type 2 Diabetes: From Injections to Hybrid Closed-Loop Therapy
Authors: Davis Georgia M. , Peters Anne L. , Bode Bruce W. , Carlson Anders L. , Dumais Bonnie , Vienneau Todd E. , Huyett Lauren M. , Ly Trang T.
Published: February 2023

OBJECTIVE

Automated insulin delivery (AID) has rarely been studied in adults with type 2 diabetes. We tested the feasibility of using AID for type 2 diabetes with the Omnipod 5 System in a multicenter outpatient trial.

RESEARCH DESIGN AND METHODS

Participants previously were using either basal-only or basal-bolus insulin injections, with or without the use of a continuous glucose monitor (CGM), and had a baseline HbA1c ≥8% (≥64 mmol/mol). Participants completed 2 weeks of CGM sensor data collection (blinded for those not previously using CGM) with their standard therapy (ST), then transitioned to 8 weeks of AID. Participants who previously used basal-only injections used the AID system in manual mode for 2 weeks before starting AID. Antihyperglycemic agents were continued at clinician discretion. Primary safety outcomes were percentage of time with sensor glucose ≥250 mg/dL and <54 mg/dL during AID. Additional outcomes included HbA1c and time in target range (TIR) (70–180 mg/dL).

RESULTS

Participants (N = 24) had a mean (± SD) age of 61 ± 8 years, baseline HbA1c of 9.4% ± 0.9% (79 ± 10 mmol/mol), and diabetes duration of 19 ± 9 years. Percentage of time with sensor glucose ≥250 mg/dL decreased with AID by 16.9% ± 16.2% (P < 0.0001), whereas percentage of time at <54 mg/dL remained low during both ST and AID (median [interquartile range] 0.0% [0.00%, 0.06%] vs. 0.00% [0.00%, 0.03%]; P = 0.4543). HbA1c (± SD) decreased by 1.3% ± 0.7% (14 ± 8 mmol/mol; P < 0.0001) and TIR increased by 21.9% ± 15.2% (P < 0.0001) without a significant change in total daily insulin or BMI with AID.

CONCLUSIONS

Findings from this feasibility trial of AID in adults with type 2 diabetes with suboptimal glycemic outcomes justify further evaluation of this technology in this population.
Glomerular Hyperfiltration Predicts Kidney Function Decline and Mortality in Type 1 and Type 2 Diabetes: A 21-Year Longitudinal Study
Authors: Moriconi Diego , Sacchetta Luca , Chiriacò Martina , Nesti Lorenzo , Forotti Giovanna , Natali Andrea , Solini Anna , Tricò Domenico
Published: February 2023

OBJECTIVE

To evaluate the prognostic value of glomerular hyperfiltration on long-term kidney-related outcomes and mortality in patients with diabetes.

RESEARCH DESIGN AND METHODS

We retrospectively analyzed 21-year longitudinal data from 314 patients with long-standing type 1 or type 2 diabetes. Glomerular hyperfiltration was identified based on the age- and sex-specific distribution of measured glomerular filtration rate (mGFR) by 99mTc-DTPA dynamic renal scintigraphy. The primary outcome was a composite of doubling of serum creatinine, end-stage kidney disease (ESKD), or cardiorenal death. The kidney-specific outcome was a composite of doubling of serum creatinine, ESKD, or renal death.

RESULTS

Over a median of 21.0 years, the primary composite outcome occurred in 25 (39.7%), 24 (38.1%), and 46 (24.5%) participants with high mGFR (H-mGFR) (n = 63), low mGFR (L-mGFR) (n = 63), or normal mGFR (N-mGFR) (n = 188), respectively. Compared with N-mGFR, the hazard ratio (HR) for the primary composite outcome was 2.09 (95% CI 1.25–3.49) in H-mGFR and 1.81 (1.05–3.16) in L-mGFR. The HR for the kidney-specific composite outcome was 4.95 (2.21–11.09) in H-mGFR and 3.81 (1.70–8.56) in L-mGFR. The HRs for doubling of serum creatinine and cardiorenal death were 4.86 (2.18–10.90) and 2.18 (1.24–3.83) in H-mGFR and 4.04 (1.77–9.20) and 2.26 (1.27–4.01) in L-mGFR, respectively.

CONCLUSIONS

Glomerular hyperfiltration, similar to hypofiltration, increases the combined risk of worsening kidney function and mortality from cardiovascular or renal causes in patients with diabetes. These findings encourage the active screening of these patients to optimize risk stratification and treatment of subclinical kidney disease.
Effects of Intensive Systolic Blood Pressure Lowering on End-Stage Kidney Disease and Kidney Function Decline in Adults With Type 2 Diabetes Mellitus and Cardiovascular Risk Factors: A Post Hoc Analysis of ACCORD-BP and SPRINT
Authors: Tawfik Yahya M.K. , Van Tassell Benjamin W. , Dixon Dave L. , Baker William L. , Fanikos John , Buckley Leo F.
Published: February 2023

OBJECTIVE

To determine the effects of intensive systolic blood pressure (SBP) lowering on the risk of major adverse kidney outcomes in people with type 2 diabetes mellitus (T2DM) and/or prediabetes and cardiovascular risk factors.

RESEARCH DESIGN AND METHODS

This post hoc ACCORD-BP subgroup analysis included participants in the standard glucose-lowering arm with cardiovascular risk factors required for SPRINT eligibility. Cox proportional hazards regression models compared the hazard for the composite of dialysis, kidney transplant, sustained estimated glomerular filtration rate (eGFR) <15 mL/min/1.73 m2, serum creatinine >3.3 mg/dL, or a sustained eGFR decline ≥57% between the intensive (<120 mmHg) and standard (<140 mmHg) SBP-lowering arms.

RESULTS

The study cohort included 1,966 SPRINT-eligible ACCORD-BP participants (40% women) with a mean age of 63 years. The mean SBP achieved after randomization was 120 ± 14 and 134 ± 15 mmHg in the intensive and standard arms, respectively. The kidney composite outcome occurred at a rate of 9.5 and 7.2 events per 1,000 person-years in the intensive and standard BP arms (hazard ratio [HR] 1.35 [95% CI 0.85–2.14]; P = 0.20). Intensive SBP lowering did not affect the risk of moderately (HR 0.96 [95% CI 0.76–1.20]) or severely (HR 0.92 [95% CI 0.66–1.28]) increased albuminuria. Including SPRINT participants with prediabetes in the cohort did not change the overall results.

CONCLUSIONS

This post hoc subgroup analysis suggests that intensive SBP lowering does not increase the risk of major adverse kidney events in individuals with T2DM and cardiovascular risk factors.
Investigating gene-diet interactions impacting the association between macronutrient intake and glycemic traits
Authors: Westerman Kenneth E. , Walker Maura E. , Gaynor Sheila M. , Wessel Jennifer , DiCorpo Daniel , Ma Jiantao , Alonso Alvaro , Aslibekyan Stella , Baldridge Abigail S. , Bertoni Alain G. , Biggs Mary L. , Brody Jennifer A. , Chen Yii-Der Ida , Dupuis Josee , Goodarzi Mark O. , Guo Xiuqing , Hasbani Natalie R. , Heath Adam , Hidalgo Bertha , Irvin Marguerite R. , Johnson W. Craig , Kalyani Rita R. , Lange Leslie , Lemaitre Rozenn N. , Liu Ching-Ti , Liu Simin , Moon Jee-Young , Nassir Rami , Pankow James S. , Pettinger Mary , Raffield Laura , Rasmussen-Torvik Laura J. , Selvin Elizabeth , Senn Mackenzie K. , Shadyab Aladdin H. , Smith Albert V. , Smith Nicholas L. , Steffen Lyn , Talegakwar Sameera , Taylor Kent D. , Vries Paul S. de , Wilson James G. , Wood Alexis C. , Yanek Lisa R. , Yao Jie , Zheng Yinan , Boerwinkle Eric , Morrison Alanna C. , Fornage Miriam , Russell Tracy P. , Psaty Bruce M. , Levy Daniel , Heard-Costa Nancy L. , Ramachandran Vasan S. , Mathias Rasika A. , Arnett Donna K. , Kaplan Robert , North Kari E. , Correa Adolfo , Carson April , Rotter Jerome I. , Rich Stephen S. , Manson JoAnn E. , Reiner Alexander P. , Kooperberg Charles , Florez Jose C. , Meigs James B. , Merino Jordi , Tobias Deirdre K. , Chen Han , Manning Alisa K.
Published: February 2023

Few studies have demonstrated reproducible gene-diet interactions (GDIs) impacting metabolic disease risk factors, likely due in part to measurement error in dietary intake estimation and insufficient capture of rare genetic variation. We aimed to identify GDIs across the genetic frequency spectrum impacting the macronutrient-glycemia relationship in genetically and culturally diverse cohorts. We analyzed N=33,187 diabetes-free participants from 10 NHLBI Trans-Omics for Precision Medicine (TOPMed) program cohorts with whole-genome sequencing, self-reported diet, and glycemic trait data. We fit cohort-specific, multivariable-adjusted linear mixed models for the effect of diet, modeled as an isocaloric substitution of carbohydrate for fat, and its interactions with common and rare variants genome-wide. In main effect meta-analyses, participants consuming more carbohydrate had modestly lower glycemic trait values (e.g. for hemoglobin A1c [HbA1c], -0.013 %HbA1c per 250 kcal substitution). In GDI meta-analyses, a common African ancestry-enriched variant (rs79762542) reached study-wide significance and replicated in the UK Biobank cohort, indicating a negative carbohydrate-HbA1c association among major allele homozygotes only. Simulations revealed that over 150,000 samples may be necessary to identify similar macronutrient GDIs under realistic assumptions about effect size and measurement error. These results generate hypotheses for further exploration of modifiable metabolic disease risk in additional cohorts with African ancestry.
Powder catchment efficiency in laser cladding (directed energy deposition). An investigation into standard laser cladding and the ABA cladding technique
Authors: Koti Daniel , Powell John , Naesstroem Himani , Voisey K. T.
Published: February 2023

This paper investigates the efficiency of powder catchment in blown powder laser cladding (a directed energy deposition technique). A comparison is made between standard “track by overlapping track” cladding (“AAA” cladding) and “ABA” cladding, where the gaps left between an initial set of widely spaced tracks (“A” tracks), are filled in by subsequent “B” tracks. In both these techniques, the melt pool surface is the collection area for the cladding powder, and the shape of this pool can be affected by several parameters including cladding speed, intertrack spacing, and type of cladding technique. The results presented here are derived from of an analysis of high-speed videos taken during processing and cross sections of the resultant clad tracks. The results show that the first track in AAA cladding has a different melt pool shape to subsequent tracks, and that the asymmetry of the subsequent track melt pools results in a reduction in the powder catchment efficiency. In contrast to this, the geometry of the “B” track melt pools between their adjacent “A” tracks results in an enhanced powder catchment efficiency.
Employer Brand Building Strategy in the Labour Market: Methodical Procedure for Companies from B2B and B2C Markets
Authors: Skýpalová Renata , Vencourová Monika , Hynková Vendula
Published: February 2023

The contribution of this study is the identification of dependencies and assumptions about the relationship of selected variables within the employer brand building process and the proposed methodological procedure for employer brand building (the EB Concept) that should contribute to easier implementation of the employer brand building strategy in the labour market. This methodological procedure is based on theoretical knowledge and the basis of available literature in the field of building the employer's brand and the practice of the authors. The methodological procedure can be applied to companies with different characteristics. They can be of different industry, different legal forms, number of employees, operating on the B2B and B2C market. The application of the methodological procedure requires support throughout the company. From the CEO, through top management, middle management to the employees themselves. The authors of the study used first the available literature and information on the process of employer brand building. This was followed by communication with four selected companies, where a unified scheme for introducing the employer brand concept was gradually set up. Two companies were SME, two large companies with more than 250 employees. At the same time, two companies operate in B2B and two in B2C markets. The proposed unified concept of introducing the employer brand is also usable in SMEs and large companies.
Modely analýzy obalu dat s fixním součtem výstupů
Authors: Jablonský Josef
Published: February 2023

raditional data envelopment analysis (DEA) models do not consider any relations with respect to the sum of values of outputs. In many real applications, the sum of outputs is predetermined and cannot be changed. In this paper, main models considering fixed-sum outputs are formulated and discussed their properties. They usually proceed in two steps. The first step consists in deriving a new efficient frontier, usually called equilibrium efficient frontier. This frontier is computed in such a way that the values offixed-sum outputs for all units are modified to reach maximum efficiency of all units. In the second step, the efficiency score of the original units is derived with respect to the new frontier. This characteristic allows complete ranking of the units. The results of the model are illustrated on the evaluation of efficiency ofcountries attending Winter Olympic Games 2022. They are compared with traditional DEA models.
Fenomenología y metodologías del arte, estudio de contraste
Authors: Delgado Coellar Alma Elisa , Velázquez Ruíz Daniela
Published: February 2023

El presente artículo describe dos enfoques paradigmáticos de la historia de la ciencia. Por un lado, las ciencias de la naturaleza, y por otro, las ciencias del espíritu. Esto funciona como un preámbulo hacia las metodologías del arte que inciden en un estudio profundo del proceso generador de la obra, no en miras de una evaluación de un producto final y/o terminado, sino por el contrario, la consideración de la serie de elementos que le configuran, desde su entorno ambiental, sus condiciones socio-político-culturales, las características de la tecnología de la cual se dispone para su creación, las cualidades de quien le produce, entre otros elementos, todos estos determinantes en un pensamiento fenomenológico integrador para la investigación de las artes.
Técnicas para darle forma a lo blando
Authors: Walerko Gabriela Victoria
Published: February 2023

Este trabajo reflexiona sobre aspectos que se despliegan al momento de pensar la comunicación estratégica del patrimonio artístico en organizaciones culturales, especialmente en museos. Se establecen algunas de las razones que dieron lugar a modificaciones institucionales, a partir de cambios operados en las condiciones de producción de las obras de arte y en los modos de circulación de los flujos de imágenes que se plantean en competencia con programas de comunicación institucional del arte en la actualidad. Reconoce también la necesidad de repensar alternativas éticas, que incluyan valores y ejes de articulación de contenidos conceptuales y tecnológicos, desde una mirada situada y respetuosa del universo cultural.
El archivo entre la obra y el documento
Authors: Colombo Georgina , Ramirez Casado Guillermina
Published: February 2023

El presente artículo propone reflexionar sobre la identidad de los archivos de arte y los documentos que comprenden. Partiendo de la pregunta sobre los límites entre obra y documento, analizaremos las maneras de organizar el contenido del Fondo Carlos Ginzburg del Archivo de Arte del Centro de Arte de la Universidad Nacional de La Plata y las mediaciones que atienden a presentar la densidad crítica y artística de las piezas conservadas.
¿Qué le hace la fotografía al cuerpo?
Authors: Cappannini Cecilia
Published: February 2023

En noviembre del 2021 nos encontramos en el Seminario de Historia de la Fotografía de la Facultad de Artes (FDA) de la Universidad Nacional de La Plata (UNLP) en una charla sobre las relaciones entre fotografía y cuerpo. Este trabajo retoma algunas de esas conversaciones y analiza los modos en los que la fotografía como dispositivo construye corporalidades en la experiencia de ser captados por la cámara y de mirar. Desde una perspectiva de género interseccional, indagamos los vínculos posibles al interior de un cuerpo de imágenes aún en formación: The Hidden Mother (2013) de Linda Fregni Nagler, 97 empleadas domésticas (2010) de Daniela Ortiz, y Semiotics of the Kitchen (1975), de Martha Rosler.
PENDIDIKAN AKHLAK MULIA MELALUI MAJLIS ZIKIR
Authors: Rahman Abd.
Published: February 2023

Pendidikan akhlak mulia terhadap manusia bukanlah pekerjaan ringan. Maka dari itu, majlis zikir perlu diperhatikan secara intensif dan harus diberikan waktu tertentu dan terpenting adalah aplikasinya. Adapun aplikasi zikir ada tiga yaitu: 1. Zikir Qalbiyah (hati) maksudnya adalah segalah sesuatu yang akan dilaksanakan harus berawal pada kesucian hati dan keikhlasan niat untuk Allah Swt. 2. Zikir Qauliyah (ucapan) maksudnya adalah segala ucapan yang akan dikeluakan pada lisan harus bermanfaat pada diri sendiri dan orang lain. 3. Zikir Fi’liyah (perbuatan) maksudnya adalah segala perbuatan dan pergaulan harus dijaga dalam kehidupan sehari-harinya.

 Akhlak mulia akan membawa manfaat pada Qalb (hati), agar tetap hidup bersih dan bercahaya. Sebab hati yang hidup dan bercahaya akan menjadi modal segala kebaikan, kesuksesan dan keselamatan hidup di dunia dan akhirat. Karena dasar segala kebaikan dan keselamatan khamba adalah hati yang bersih dan bercahaya, bahkan setiap makhluk hidup adalah kesempurnaan hidup dan cahayanya. Allah Swt telah menghimpun dua dasar yakni kehidupan dan cahaya. Hidup akan melahirkan kekuatan pendengaran, penglihatan, malu, keberanian, kesabaran dan segenap akhlak mulia lainnya.

Dengan berakhlak mulia, manusia akan memperoleh beberapa manfaat dari akhlaknya yakni; a) agamanya semakin kuat, b) dimudahkan perhitungan amalnya pada yaumul hisab (hari perhitungan amal), c) Ketika mendapat kesulitan selalu juga mendapat solusi dari Allah Swt, d) dijamin keselamataanya disunia dan akhirat.
KONSEP KEPEMIMPINAN PENDIDIKAN DALAM MENGEMBANGKAN PRINSIP PEMBERDAYAAN MASYARAKAT
Authors: Marjuni H. Andi
Published: February 2023

Leadership is the process of inspiring others to work hard to achieve important work. Leadership builds commitment and enthusiasm for people to implement their talents to help achieve plans, oversight so as to make sure everything goes well. In its activities, the leader has the power to mobilize and influence his subordinates with respect to the tasks that must be carried out. At the stage of assigning tasks, the leader must provide clear direction and guidance, so that subordinates can carry out their duties easily and the results achieved are in accordance with the goals that have been set. Conceptually, the term empowerment has the basic word "daya" which means ability, strength, effort, ability to do business. Empowerment in education can be interpreted as a process of making human resources capable or strong in carrying out a business in a particular field in the field of education. , including reducing the effects of personal and social barriers to action
ANALISIS BUKU TEKS BAHASA ARAB MADRASAH ALIYAH KELAS XII TERBITAN KEMENTERIAN AGAMA	DAN ERLANGGA
Authors: . Mahfudz , Garancang Sabaruddin , . Haniah , Ima Nur
Published: February 2023

This study aims to analyze and compare the quality of MA Arabic textbooks for class XII published by the Ministry of Religion and Erlangga, based on BSNP standards, namely: content aspects, presentation aspects, language aspects and graphic aspects. This research using qualitative content analysis to analyze textbooks Arabic. The steps taken are the formulation of the analysis objectives,Data grouping, assessment of the percentage component items of each subcomponents and aspects of feasibility and data analysis. The results of the study are Arabic textbooks published by the Ministry of Religion from the content feasibility component have a very good category, in terms of the presentation component in the good category, the linguistic component in the good category and the last component in terms of the graphic of this book has a very good quality. Arabic text book published by PT. Erlangga seen from the four components of the BSNP standard has very good quality, in terms of content, presentation, language and graphics. Comparison between the two books, the Arabic textbook published by PT. Erlangga is superior to Arabic textbooks published by the Ministry of Religion in terms of presentation and linguistic aspects. In terms of content and graphic aspects, the two books have a balanced quality.
OPTIMALISASI PENDIDIKAN AL-QUR’AN DALAM PENGEMBANGAN PENDIDIKAN AGAMA ISLAM
Authors: . Rosmiyati , Abubakar Achmad , Abunawas Kamaluddin , Mas’ud Mukhtar
Published: February 2023

The basis for implementation Al-Qur'an education includes Government policies, financing, namely funding sources, education management functions in the implementation of Al-Qur'an education, utilization of human resources, and members as well as students. Implementation challenges of Al-Qur'an education, among others: the era of globalization, human moral decadence, and prioritizing world affairs that can provide something material and less inclined to pursue amaliyah for preparation and provision in the hereafter. Expectations in the implementation of Al-Qur'an education, among others: building believers and increasing intelligence in the field of religion, increasing friendship and Ukhuwah Islamiyah relations, and centers of knowledge in society, namely the implementation of Al-Qur'an education provides great hope for Muslims, namely the information center for the development of Islamic knowledge, the center for fostering Islamic knowledge, and the Islamic religious consultation center.
PENGARUH SELF-EFFICACY TERHADAP PRESTASI BELAJAR BAHASA ARAB PESERTA DIDIK DI MTS AL-IKHWAN BAUBAU
Authors: Najam Ahmad Fitratun , Usman Syahruddin , Kasim Amrah
Published: February 2023

This study aims to describe the self-efficacy and learning achievement of Arabic students at Mts Al-Ikhwan Baubau, as well as to examine the effect of self-efficacy on Arabic learning achievement of students at Mts Al-Ikhwan Baubau. This research uses quantitative method with causal associative type. The population of this study were all students at Mts Al-ikhwan Baubau who were in class VIII and IX as many as 46 students, the sample in this study were all members of the population. Data collection techniques were carried out using questionnaires and tests. The collected data were analyzed using descriptive analysis and inferential analysis. The results obtained: 1) self-efficacy and Arabic learning achievement of students at Mts Al-Ikhwan Baubau are in the medium category. 2) the results of inferential statistical calculations obtained p-value <α (0.008 <0.05) and the regression coefficient (b) of 0.224 so that H0 is rejected and H1 is accepted, this means that self-efficacy has a positive effect on participants' Arabic learning achievement educate.
Pengaruh Manajemen Waktu, Motivasi Kerja dan Kinerja Guru Terhadap Kompetensi Profesional Guru
Authors: Al Munawwarah Rofiqah , Bahri Jamal Bahri
Published: February 2023

This research was carried out by all State Vocational Schools in Soppeng Regency, South Sulawesi Province. In this study, the population is 57 teachers of State Vocational Schools in Kabupaten Soppeng. The sampling technique in this study using Simple random sampling is said to be simple (simple because sampling is done randomly without regard to the existing strata in the population. The data analysis tool used in this study is research with multiple linear regression. Based on the results of the research conducted, it shows that: Time Management has a positive and significant effect on teachers' Professionals in SMKN Kabupaten Soppeng, Teacher Motivation has a positive and significant effect on teacher Professionals in SMKN Kabupaten Soppeng District, Teacher Performance has a positive and significant effect on Professionals Teachers at SMKN Kabupaten Soppeng, Time Management, Work Motivation and Teacher Performance simultaneously had a positive and significant effect on teacher Professionals in SMKN Kabupaten Soppeng.