bluuebunny/crossref_metadata_2025 huggingface dataset:
The Construction of a Multidomain Risk Model of Alzheimer’s Disease and Related Dementias
Authors: Akushevich Igor , Yashkin Arseniy , Ukraintseva Svetlana , Yashin Anatoliy I. , Kravchenko Julia
Published: October 2023

Background: Alzheimer’s disease (AD) and related dementia (ADRD) risk is affected by multiple dependent risk factors; however, there is no consensus about their relative impact in the development of these disorders. Objective: To rank the effects of potentially dependent risk factors and identify an optimal parsimonious set of measures for predicting AD/ADRD risk from a larger pool of potentially correlated predictors. Methods: We used diagnosis record, survey, and genetic data from the Health and Retirement Study to assess the relative predictive strength of AD/ADRD risk factors spanning several domains: comorbidities, demographics/socioeconomics, health-related behavior, genetics, and environmental exposure. A modified stepwise-AIC-best-subset blanket algorithm was then used to select an optimal set of predictors. Results: The final predictive model was reduced to 10 features for AD and 19 for ADRD; concordance statistics were about 0.85 for one-year and 0.70 for ten-year follow-up. Depression, arterial hypertension, traumatic brain injury, cerebrovascular diseases, and the APOE4 proxy SNP rs769449 had the strongest individual associations with AD/ADRD risk. AD/ADRD risk-related co-morbidities provide predictive power on par with key genetic vulnerabilities. Conclusion: Results confirm the consensus that circulatory diseases are the main comorbidities associated with AD/ADRD risk and show that clinical diagnosis records outperform comparable self-reported measures in predicting AD/ADRD risk. Model construction algorithms combined with modern data allows researchers to conserve power (especially in the study of disparities where disadvantaged groups are often grossly underrepresented) while accounting for a high proportion of AD/ADRD-risk-related population heterogeneity stemming from multiple domains.
Family History of Dementia in Old-Age Participants with Subjective Memory Complaints Predicts Own Risk for Dementia in a Longitudinal Multi-Center Cohort Study
Authors: Heser Kathrin , Kleineidam Luca , Wagner Michael , Luppa Melanie , Löbner Margrit , Wiese Birgitt , Oey Anke , König Hans-Helmut , Brettschneider Christian , van der Leeden Carolin , van den Bussche Hendrik , Fuchs Angela , Pentzek Michael , Weyerer Siegfried , Werle Jochen , Bickel Horst , Scherer Martin , Maier Wolfgang , Ramirez Alfredo , Riedel-Heller Steffi G.
Published: October 2023

Background: Subjective memory complaints and family history of dementia are possibly intertwined risk factors for the own subsequent dementia risk and Alzheimer’s disease. However, their interaction has rarely been studied. Objective: To study the association between subjective memory complaints and family history of dementia with regard to the own subsequent risk of dementia. Methods: Cross-sectional and longitudinal analyses over a follow-up period of up to 13 years were conducted in a population sample of participants without dementia at baseline (n = 3,256, mean age = 79.62 years), using group comparisons and Cox proportional hazards models. Results: Cross-sectionally, participants with subjective memory complaints were significantly more likely to report family history of dementia. Longitudinally, family history of dementia (FH) was significantly associated with subsequent dementia in the subjective memory complaints (SMC) group, but not in those without SMC. A relative excess risk due to interaction analysis confirmed a significant FHxSMC-interaction. Conclusions: Family history of dementia was a predictor of incident dementia in those with SMC, which can serve as an additional, clinically relevant criterion to gauge the risk of dementia in older-aged subjects with SMC with and without objective cognitive impairment.
Protective Effects of Rivaroxaban on White Matter Integrity and Remyelination in a Mouse Model of Alzheimer’s Disease Combined with Cerebral Hypoperfusion
Authors: Bian Zhihong , Hu Xinran , Liu Xia , Yu Haibo , Bian Yuting , Sun Hongming , Fukui Yusuke , Morihara Ryuta , Ishiura Hiroyuki , Yamashita Toru
Published: October 2023

Background: Alzheimer’s disease (AD) is characterized by cognitive dysfunction and memory loss that is accompanied by pathological changes to white matter. Some clinical and animal research revealed that AD combined with chronic cerebral hypoperfusion (CCH) exacerbates AD progression by inducing blood-brain barrier dysfunction and fibrinogen deposition. Rivaroxaban, an anticoagulant, has been shown to reduce the rates of dementia in atrial fibrillation patients, but its effects on white matter and the underlying mechanisms are unclear. Objective: The main purpose of this study was to explore the therapeutic effect of rivaroxaban on the white matter of AD+CCH mice. Methods: In this study, the therapeutic effects of rivaroxaban on white matter in a mouse AD+CCH model were investigated to explore the potential mechanisms involving fibrinogen deposition, inflammation, and oxidative stress on remyelination in white matter. Results: The results indicate that rivaroxaban significantly attenuated fibrinogen deposition, fibrinogen-related microglia activation, oxidative stress, and enhanced demyelination in AD+CCH mice, leading to improved white matter integrity, reduced axonal damage, and restored myelin loss. Conclusions: These findings suggest that long-term administration of rivaroxaban might reduce the risk of dementia.
Body Mass Index Decrease Has a Distinct Association with Alzheimer’s Disease Pathophysiology in APOE ɛ4 Carriers and Non-Carriers
Authors: Li Anqi ,   for the Alzheimer’s Disease Neuroimaging Initiative, Du Jing , Cai Yue , Chen Xuhui , Sun Kun , Guo Tengfei
Published: October 2023

Background: Body mass index (BMI) changes may be related to Alzheimer’s disease (AD) alterations, but it is unclear how the apolipoprotein E ɛ4 (APOE ɛ4) allele affects their association. Objective: To explore the association of BMI changes with AD pathologies in APOE ɛ4 carriers and non-carriers. Methods: In 862 non-demented ADNI participants with≥2 BMI measurements, we investigated the relationships between BMI slopes and longitudinal changes in amyloid-β (Aβ) accumulation, neurodegeneration and cognition, and follow-up tau deposition in different Aβ and APOE ɛ4 statuses. Results: In Aβ+ APOE ɛ4 non-carriers, faster BMI declines were associated with faster rates of Aβ accumulation (standardized β (βstd) = –0.29, p = 0.001), AD meta regions of interest (metaROI) hypometabolism (βstd = 0.23, p = 0.026), memory declines (βstd = 0.17, p = 0.029), executive function declines (βstd = 0.19, p = 0.011), and marginally faster Temporal-metaROI cortical thinning (βstd = 0.15, p = 0.067) and higher follow-up Temporal-metaROI tau deposition (βstd = –0.17, p = 0.059). Among Aβ- individuals, faster BMI decreases were related to faster Aβ accumulation (βstd = –0.25, p = 0.023) in APOE ɛ4 carriers, whereas predicted faster declines in memory and executive function in both APOE ɛ4 carriers (βstd = 0.25, p = 0.008; βstd = 0.32, p = 0.001) and APOE ɛ4 non-carriers (βstd = 0.11, p = 0.030; βstd = 0.12, p = 0.026). Conclusions: This study highlights the significance of tracking BMI data in older adults by providing novel insights into how body weight fluctuations and APOE ɛ4 interact with AD pathology and cognitive decline.
Chain Mediation Analysis of the Effects of Nutrition and Cognition on the Association of Apolipoprotein E ɛ4 with Neuropsychiatric Symptoms in Alzheimer’s Disease
Authors: Jiang Jiwei , Hong Yin , Li Wenyi , Wang Anxin , Jiang Shirui , Jiang Tianlin , Wang Yanli , Wang Linlin , Yang Shiyi , Ren Qiwei , Zou Xinying , Xu Jun
Published: October 2023

Background: Apolipoprotein E (APOE) is the most recognized risk gene for cognitive decline and clinical progression of late-onset Alzheimer’s disease (AD); nonetheless, its association with neuropsychiatric symptoms (NPSs) remains inconclusive. Objective: To investigate the association of APOE ɛ4 with NPSs and explore nutritional status and cognition as joint mediators of this association. Methods: Between June 2021 and October 2022, patients with amnestic mild cognitive impairment (aMCI) or AD were recruited from the Chinese Imaging, Biomarkers, and Lifestyle Study. NPSs were assessed using the Neuropsychiatric Inventory, while global cognition and nutritional status were evaluated using the Mini-Mental State Examination (MMSE) and Mini-Nutritional Assessment (MNA), respectively. Simple mediation and multiple chain mediation models were developed to examine the mediating effects of the MNA and MMSE scores on the relationship between APOE ɛ4 and specific neuropsychiatric symptom. Results: Among 310 patients, 229 (73.87%) had NPSs, and 110 (35.48%) carried APOE ɛ4. Patients with APOE ɛ4 were more likely to have hallucinations (p = 0.014), apathy (p = 0.008), and aberrant motor activity (p = 0.018). MNA and MMSE scores mediated the association between APOE ɛ4 and hallucinations (17.97% and 37.13%, respectively), APOE ɛ4 and apathy (30.73% and 57.72%, respectively), and APOE ɛ4 and aberrant motor activity (17.82% and 34.24%), respectively. Chain-mediating effects of MNA and MMSE scores on the association of APOE ɛ4 with hallucinations, apathy, and aberrant motor activity after adjusting for confounding factors were 6.84%, 11.54%, and 6.19%, respectively. Conclusion: Nutritional status and cognition jointly mediate the association between APOE ɛ4 and neuropsychiatric symptoms in patients with aMCI or AD.
Multi-Site Cross-Site Inter-Rater and Test-Retest Reliability and Construct Validity of the MarkVCID White Matter Hyperintensity Growth and Regression Protocol
Authors: Bahrani Ahmed A. , Abner Erin L. , DeCarli Charles S. , Barber Justin M. , Sutton Abigail C. , Maillard Pauline , Sandoval Francisco , Arfanakis Konstantinos , Yang Yung-Chuan , Evia Arnold M. , Schneider Julie A. , Habes Mohamad , Franklin Crystal G. , Seshadri Sudha , Satizabal Claudia L. , Caprihan Arvind , Thompson Jeffrey F. , Rosenberg Gary A. , Wang Danny J.J. , Jann Kay , Zhao Chenyang , Lu Hanzhang , Rosenberg Paul B. , Albert Marilyn S. , Ali Doaa G. , Singh Herpreet , Schwab Kristin , Greenberg Steven M. , Helmer Karl G. , Powel David K. , Gold Brian T. , Goldstein Larry B. , Wilcock Donna M. , Jicha Gregory A.
Published: October 2023

Background: White matter hyperintensities (WMH) that occur in the setting of vascular cognitive impairment and dementia (VCID) may be dynamic increasing or decreasing volumes or stable over time. Quantifying such changes may prove useful as a biomarker for clinical trials designed to address vascular cognitive-impairment and dementia and Alzheimer’s Disease. Objective: Conducting multi-site cross-site inter-rater and test-retest reliability of the MarkVCID white matter hyperintensity growth and regression protocol. Methods: The NINDS-supported MarkVCID Consortium evaluated a neuroimaging biomarker developed to track WMH change. Test-retest and cross-site inter-rater reliability of the protocol were assessed. Cognitive test scores were analyzed in relation to WMH changes to explore its construct validity. Results: ICC values for test-retest reliability of WMH growth and regression were 0.969 and 0.937 respectively, while for cross-site inter-rater ICC values for WMH growth and regression were 0.995 and 0.990 respectively. Word list long-delay free-recall was negatively associated with WMH growth (p < 0.028) but was not associated with WMH regression. Conclusions: The present data demonstrate robust ICC validity of a WMH growth/regression protocol over a one-year period as measured by cross-site inter-rater and test-retest reliability. These data suggest that this approach may serve an important role in clinical trials of disease-modifying agents for VCID that may preferentially affect WMH growth, stability, or regression.
The association of subacute thyroiditis with viral diseases: a comprehensive review of literature
Authors: Rafiei N. , Masoudi M. , Jadidi H. , Ghaedi A. , Jahani N. , Ebrahimi S. , Gharei F. , Amirhoushangi H. , Bayat M. , Ansari A. , Hamedanchi N. F. , Hosseini P. , Elmi S. , Garousi S. , Mottahedi M. , Ghasemi M. , Alizadeh A. , Deravi N.
Published: October 2023

INTRODUCTION. Subacute thyroiditis (SAT), also known as de Quatrain’s thyroiditis or granulomatous thyroiditis, is an inflammatory disease of the thyroid. Most of the time, it manifests in the thirties to fifties and is more common in women. SAT can have either viral or post-viral origin. Some viruses, like influenza, COVID-19, Epstein–Barr virus, cytomegalovirus, hepatitis, coxsackievirus 16, and mumps virus, have been linked to SAT development. The COVID-19 pandemic has affected people’s lives all around the world and has changed our attitude toward the treatment of many diseases. It has also made us look deeper into the subject in a way that we would be able to treat this sort of disease with a newer insight.
OBJECTIVE. Regarding the importance of this issue, we decided to summarize our extensive searches from online databases, including PubMed, Google Scholar, Medline, Web of Science, and Scopus until February 2023, which we found effective in elucidating the association of subacute thyroiditis and viral diseases.
METHOD. Different online databases were searched for narrative review articles, systemic review articles, and original articles, which were published until February 2023.
RESULT. According to the included studies, we found that there is a correlation between SAT and several viruses such as Epstein-Barr virus, influenza virus, human immunodeficiency virus, cytomegalovirus, oral and cervical virus, hepatitis, dengue virus, and SARS-COV-2. The effect of each of the viral diseases mentioned in the SAT is given in the text.
CONCLUSIONS. According to the results mentioned in the text, because SAT may be challenging for early diagnosis, due to the potential of classic symptoms as well as the interference of similar clinical symptoms between thyrotoxicosis and viral reactions, the correlation between SAT and viral diseases should be considered so that we can avoid misdiagnosis and lateness.
ANALISIS PENINGKATAN MUTU LEMBAGA PENDIDIKAN PESANTREN MELALUI MANAJEMEN HUMAS
Authors: Inayati Mahfida , Mulyadi Mulyadi , Nurhadi Ali
Published: October 2023

Improving the quality of pesantren educational institutions through public relations management can be done by developing and applying appropriate public relations techniques. Pesantren educational institutions are traditional educational institutions that have their own management but do not deny changes in the current digital era. Public relations has a very important role in the relationship between two parties both from internal and external segments which aims to improve the quality of pesantren educational institutions. So to create a good communication, a good relationship is also needed by making an institution have solid management in the field of public relations. the application of public relations techniques according to Jefrerson and DeRoche theories where the techniques developed are written, oral, demonstration and electronic techniques. Public relations techniques can combine electronic techniques with written, oral or other techniques. This can make it easier for the wider community to get information, ideas or activity reports that can integrate between the institution and the wider community.
Motivasi Kerja dan Sikap Inovatif Guru Fiqh di MAN Insan Cendekia Aceh Timur
Authors: Basri Basri
Published: October 2023

Tujuan daripenelitianiniadalahuntukmengetahuibagaimanatingkatmotivasikerja guru dan sikapinovatif di MAN InsanCendikia Aceh timur. Penelitianinimerupakanpenelitiankualitatifdeskriptif. Data dikumpulkanmelaluiwawancara, observasi, dan dokumentasi. Subject penelitianiniadalah guru fiqh dan Kepalasekolah. Guru merupakan salah satufaktorpenting yang harusdiperhatikan oleh pihaksekolah  dalamrangkamencapaitujuanpembelajaran. Berdasarkan data, banyakpendidik yang tidakprofesionalketikamenjalankantanggungjawabnya. Anggapanbahwamengajarhanyalahsekedarmentrasferpengetahuankepada murid. Pemikirin yang demikianakanmenjadiancaman yang sangat mengkhawatirkandalam dunia pendidikan di Indonesia. Sehinggabanyak guru yang tidakmenunjukkanetoskerja yang maksimaldalamtugasnya. Misalnya: pembelajaran yang statis dan terkesanmonotone, kurangnyakeuletandalammelaksanakantugas dan tanggungjawabnya. Kurangnyamotivasi guru dalammengajarmenjadikansiswacepatbosandalambelajar. Karena tidakadainisiatifuntukmelakukanhalbaru yang unik demi membangkitkansemangatbelajarsiswa. Kurangnyamotivasi guru dalammengajarberkaitandengantidakadanyasikapinovatifdalamdiri guru tersebut. Hasil penelitianmenyimpulkanbahwapengajar MAN Cendikia Aceh Timur memilikimotivasicukuptinggi, mulaidaripengaruhlingkunganataupunadanyaintensif, pujian dan juga perhatian.
Determinants of Employee Performance PT. Perkebunan Nusantara in North Sumatra
Authors: Chandra Dody Salden , Nainggolan Edisah Putra , Hidayat Rahmat
Published: October 2023

This study aims to analyze the determinants of factors that influence the performance of employees of PT. Nusantara Plantations in North Sumatra. Employee Performance is influenced by several factors including Compensation, Authentic Leadership Style, and Intrinsic Motivation. The population in this study is PT. Perkebunan Nusantara in North Sumatra and taking samples in Medan City, namely PTPN II, and PTPN III. This study used a quantitative approach, the data were analyzed using multiple linear regression analysis techniques. The results of the study show that partially and simultaneously compensation, authentic leadership style, and intrinsic motivation have a positive and significant effect on employee performance.
APPLICATION OF ALTERNATIVE PUNISHMENTS (IN DIFFERENT COUNTRIES OF THE WORLD)
Authors:   Territorially Separated Branch “Khmelnytskyi Branch of the Academy of the State Penitentiary Service”,  Khmelnytskyi, Ukraine, Lorens D.V. , Shtykun O.V. ,   Territorially Separated Branch “Khmelnytskyi Branch of the Academy of the State Penitentiary Service”,  Khmelnytskyi, Ukraine, Kemeniash A.A. ,   Territorially Separated Branch “Khmelnytskyi Branch of the Academy of the State Penitentiary Service”,  Khmelnytskyi, Ukraine
Published: October 2023

The article examines the legal systems of European countries in terms of alternative punishments to deprivation of liberty. Legal systems of serving sentences mainly consist of criminal, criminal executive and penitentiary codes. It is they who determine the very system of punishments of the country, the procedure for serving punishments and the possibility of an alternative when choosing a punishment. Alternative punishments should be considered to be those that can replace imprisonment or restriction of liberty. An alternative such as probation is associated with restriction of freedom in Ukraine. Among the alternatives in other countries, fines are the most common. Fines are imposed for crimes for which damages can be compensated in monetary terms. But not all such consequences of criminal offenses can be changed to monetary compensation: this should be provided for in the criminal code. In addition, a widespread punishment abroad is the establishment of supervision in the form of probation. Such type of punishment as installation of electronic surveillance is widespread. The punishment consists in installing a means of electronic monitoring on the suspect’s body for a period of up to one year. Other types of punishments include: probation, other types of supervision, conditional sentence, conditional release from serving the sentence, treatment for alcohol or drug addiction, treatment of mental disorder. One of the similar Ukrainian punishments is community service, which is actively used as an alternative to imprisonment in Estonia and France. The author also points out the current problems associated with the implementation of the European alternative experience. Among them are martial law, the economic crisis, the workload of law enforcement officers, the presence of Soviet elements in certain types of punishments. Key words: alternative punishment, electronic control, electronic surveillance, supervision, deprivation of liberty, probation, fine.
POPULATION GROUPS WITH LOW MOBILITY: INTERNATIONAL AND NATIONAL ASPECTS OF LEGAL REGULATION
Authors:   Chernihiv Polytechnic National Academy, Chernihiv, Ukraine, Puzyrna N.S.
Published: October 2023

The article examines the essence of the category of population groups with low mobility in terms of legal regulation at the international and national level. It was noted that depending on age and health status, any person at different periods of his/her life can be classified as a low-mobility population group. Therefore, one of the urgent problems of today is the problem of creating equal opportunities for all members of society in all spheres of social life. The main problems with regard to the population groups with low mobility are emphasized as the imperfection of the legislative and normative regulation of issues of providing an accessible environment for the population groups with low mobility; the issue of creating conditions for the formation of an accessible living environment for such groups; lack or ineffectiveness of coordination and interaction of state authorities, local self-government bodies, businesses and public organizations in the field of creating an accessible environment. International standards do not contain the concept of “population groups with low mobility” and the list of persons belonging to this category. However, the creation of a real barrier-free space for groups with limited mobility is one of the primary requirements in connection with the ratification of the European Social Charter (revised), the Convention on the Elimination of All Forms of Discrimination against Women, the Convention on the Rights of Persons with Disabilities and the Association Agreement between Ukraine, on the one hand, and the European Union, the European Atomic Energy Community and their member states, on the other. In Ukraine, the legal basis for the definition of the concept of “population groups with low mobility” and the list of persons belonging to them is the Law of Ukraine “On Regulation of Urban Development Activities”, the National Strategy for the Creation of a Barrier-Free Space in Ukraine for the Period up to 2030, State Building Regulations and other normative and legal acts. Key words: population groups with low mobility, international standards, barrier-free space, normative and legal acts.
УПРАВЛІННЯ РИЗИКАМИ ДІЯЛЬНОСТІ СТРАХОВИХ КОМПАНІЙ В КОНТЕКСТІ ФІНАНСОВОЇ БЕЗПЕКИ
Authors: Глухова Валентина , Крот Людмила
Published: October 2023

Стаття присвячена дослідженню теоретико-методичних підходів до управління ризиками діяльності страхових компаній в контексті фінансової безпеки. Здійснено класифікацію ризиків, пов’язаних із провадженням страхової діяльності, за видами, що дозволило виокремити напрями управління ризиками страхової компанії. Узагальнено теоретичні засади щодо сутності фінансового ризику страхової компанії, управління фінансовими ризиками та етапів ризик-менеджменту страхової компанії. Запропоновано класифікацію фінансових ризиків страхової компанії яка, в контексті фінансової безпеки, полегшує пошук можливих шляхів їх мінімізації. Охарактеризовано наслідки неефективного управління фінансовими ризиками та систематизовано рекомендації щодо їх мінімізації для забезпечення належного рівня фінансової безпеки страхової компанії. Зроблено висновки щодо важливості системи управління ризиками, як одного з невід'ємних елементів фінансової безпеки страхових компаній.
Pengaruh Pemanfaatan Teknologi Informasi, Dukungan Manajemen Puncak Dan Kemampuan Teknik Pemakai Sistem Informasi Akuntansi Terhadap Kinerja Individu Pada Karyawan LPD Di Kabupaten Badung
Authors: Antari Ni Putu Novi Ayu , Yuniasih Ni Wayan , Cita Ayu Putu
Published: October 2023

The purpose of this study is to investigate the connection between the usage of information technology, managerial support, and technical abilities of information system users and individual performance. This study's population consisted of 240 Badung Regency Local Police Department (LPD) employees. Multiple linear regression, the coefficient of determination, the F test, and the t-test are employed for data analysis in this study. The outcomes of the study reveal that the usage of information technology has a positive and statistically significant influence on individual performance, that managerial assistance positively affects individual performance, and that personal technical ability positively affects individual performance.
Independensi, Kompetensi Profesional dan Locus Of Control dalam Mempengaruhi Kualitas Audit Judgment
Authors: Apsari Putu Ariyati , Cita ayu Putu , Hutnaleontina Putu Nuniek
Published: October 2023

This study examines how independence, professional competence, and locus of control influence audit judgment (a case study of the Bali Province Financial Audit Board). The people in this study were the forty auditors who worked for the Audit Board of the Representatives of the Province of Bali. Forty people were chosen as samples for this study using the purposive sampling method, and the results were analyzed using multiple linear regression techniques. This study's findings demonstrate that independence positively influences audit judgment. Professional competence influences audit judgment positively; locus of control influences audit judgment positively. Based on the research results, it is hoped that in the future, the auditor will maintain a certain level of independence, use the skills they already have to form a reasonable and accurate audit opinion and learn more skills that can help them make a good audit judgment.
Pengaruh Kecanggihan Teknologi Informasi, Budaya Organisasi, Dan Kemampuan Teknik Personal Terhadap Efektivitas Sistem Informasi Akuntansi Pada Koperasi Serba Usaha Di Kecamatan Sukawati
Authors: Ari Ni Made Listya , Indraswarawati Sang Ayu Putu Arie , Putra Cokorde Gde Bayu
Published: October 2023

Information systems play an important role in accounting, because basically accounting must provide accurate information to decision makers. This study aims in this study to determine the effect of sophistication of information technology, organizational culture and personal technical capabilities on the effectiveness of accounting information systems. The population in this study were employees of the Multipurpose Cooperative in Sukawati District with the sample used as many as 95 respondents. The data analysis technique used in this research is multiple linear regression, coefficient of determination, F test and t test. Based on the results of the study, it can be seen that: (1) the sophistication of tax information technology has a positive and significant effect on the effectiveness of accounting information systems, where the regression coefficient is 0.460 and sig 0.000. (2) organizational culture has a significant positive effect on the effectiveness of accounting information systems, where the regression coefficient is 0.250 and sig 0.002. (3) the ability of personal techniques has a significant positive effect on the effectiveness of accounting information systems, where the regression coefficients are 0.231 and sig 0.003. The magnitude of the influence of independent variables on the effectiveness of accounting information systems is 60%. Suggestions that can be given by researchers are Multipurpose Cooperatives in Sukawati District in increasing the tendency of the effectiveness of accounting information systems to always increase the sophistication of information technology, organizational culture and personal technical abilities.Information Technology Sophistication
Editorial: The next phase of research in academia and industry
Authors: RAMKUMAR SESHADRI
Published: October 2023

The pulp, paper, and textile sectors have contributed to lifestyle improvements for people with the development and commercialization of products like toilet tissue, facial wipes, diapers, and feminine hygiene products, to name a few. Research and development (R&D) efforts in these sectors are critical now more than ever due to the need for healthcare and lifesaving products, as became evident with the COVID-19 pandemic. Additionally, the need to meet net-zero carbon goals and the necessity to revive manufacturing in developed economies clearly emphasize the requirement to examine the R&D landscape. Academia, industry, and governments have respective roles to play in this field.
Experimental pulping kinetics of Pinus radiata cultivated in Chile
Authors: FÜLLGRAFF GÜNTHER R. , MELO DIÓGENES L. , CANALES EDGARDO R.
Published: October 2023

We adapted the Purdue model for kraft pulping kinetics for Pinus radiata wood cultivated in Chile. We cooked P. radiata chips in a batch kraft reactor at three different bulk temperatures (150ºC, 160ºC, and 170ºC) and followed wood concentrations of lignin, cellulose, galactoglucomannans, and arabinoxylans along time for up to 3 h. We compared experimental data against the kinet-ic model and determined new optimal pre-exponential factors for each wood component at each temperature. The corrected kinetic model predicted experimental data fairly well for lignin, yield, cellulose, and galactoglucomannans but was less satisfactory for arabinoxylans. The modified pulping kinetics model is more suitable for describing kraft cooking of local P. radiata species and has been validated through successful simulation of an industrial Kamyr digester.
The hemicellulose composition of pulp fibers and their ability to endure mechanical treatment
Authors: BRÄNNVALL ELISABET , LINDSTRÖM MIKAEL E.
Published: October 2023

Two pulps of different hemicellulose content were subjected to high-intensity shear forces in a laboratory mixer to damage the fibers. The ability of the fibers to resist the mechanical treatment was evaluated by comparing their strength to that of undamaged pulps. The study showed that pulp produced at high hydroxide ion concentration, which resulted in lower xylan and higher glucomannan content, was sensitive to mechanical treatment. The pulp strength decreased, evaluated as tear versus tensile index and as rewetted zero-span tensile index. Pulp with a higher xylan and lower glucomannan content could be subjected to mechanical treatment without losing strength.
Abaca as a reinforcement fiber for softwood pulp
Authors: KARLSSON HANNA , BEGHELLO LUCIANO , NILSSON LARS , STOLPE LENNART
Published: October 2023

We investigated the affect on paper strength properties of adding a neutral sulfite abaca pulp to a softwood kraft pulp. Standard isotropic laboratory handsheets were made, and sheets were also made in a dynamic sheet former. The pure abaca pulp had higher tear and tensile indices for a given refining energy than the softwood pulp. The addition of abaca to the softwood pulp increased the tear strength, fracture toughness, and folding endurance for the isotropic sheets. The tensile stiffness of isotropic sheets was independent of the abaca content, but the tensile strength decreased slightly with increasing abaca content, perhaps because the addition of abaca led to a decrease in density. The anisotropic sheets showed the same trends as the isotropic sheets. Tearing resistance and fracture toughness increased with the addition of abaca. Tensile strength and tensile stiffness were only slightly affected by the addition of abaca, but the geometric mean values for the pure abaca sheets were slightly higher than those of the pure softwood sheets.
“La niña horrible” entre la apoteosis teatral y la subversión heteropatriarcal
Authors: Chamorro Salas Jessenia
Published: October 2023

La Compañía “La Niña Horrible” ha desplegado en sus obras una poética dramática que, por un lado, problematiza la normatividad heteropatriarcal, y por otro, reivindica la espectacularidad teatral. Por ello, el objetivo del presente artículo es analizar la propuesta poética de la Compañía de teatro “La niña horrible” desplegada en tres de sus obras más representativas a lo largo de su rayectoria: Sentimientos (2013), Trágica agonía de un pájaro azul (2017), y Los tristísimos veranos de la princesa Diana (2018), en las cuales se evidencia el interés por problematizar y subvertir las normas heteropatriarcales, así como también, un deseo por alcanzar la apoteósis teatral.
Cosmogonía hyliana: mitos creacionistas entre la literatura y el videojuego The Legend of Zelda
Authors: Garcia Hernandez Jose Alejandro
Published: October 2023

El Caos originario está presente en mitos que refieren el inicio de la vida por intervención divina. La Teogonía y el Popol Vuh coinciden con el “Génesis” bíblico al atribuir una fuerza superior que establece el orden del universo. Se parte de la convergencia conceptual de los tres textos que refieren, desde civilizaciones geográficamente distantes, la figura divina como creadora de vida.Se emplea la técnica transmedia, comparando los textos literarios con el videojuego, como método de ampliación del mito de la creación, la presencia del caos-orden, así como el papel de la humanidad en el conflicto entre el bien y el mal, evidentes en la literatura y el videojuego.The Legend of Zelda es un videojuego que describe dentro de su arco narrativo la pugna del bien contra el mal. La vida es otorgada por tres diosas que dieron fin al caos e introdujeron el orden. Surge también la encarnación del mal, personaje que en principio está conformado por la ambición primitiva y que gobierna mediante un nuevo caos.La figura protagónica del relato (jugador), desarrolla la habilidad para restaurar la armonía divina. De esta forma se otorga la oportunidad de retornar el orden propuesto por las divinidades.
Efectividad del tratamiento y manejo de la glomerulonefritis membranosa en pacientes adultos
Authors: Gahona Bravo Mónica Lizbeth , Santiago Bueno Andrés
Published: October 2023

Introducción. La Glomerulonefritis Membranosa (GNM) es una patología renal crónica que afecta a los glomérulos, que son las estructuras encargadas de filtrar la sangre en los riñones. El tratamiento oportuno y el manejo adecuado de la nefropatía membranosa en pacientes adultos es fundamental para mejorar la calidad de vida de los pacientes. Objetivo. Describir los enfoques terapéuticos más efectivos y los factores que pueden influir en la respuesta al tratamiento para un diagnóstico y manejo temprano de la glomerulonefritis membranosa. Metodología. Estudio descriptivo tipo narrativo realizado mediante la recopilación sistemática de datos, en el cual se seleccionó una muestra representativa de investigaciones científicas relevantes para el tratamiento y manejo de la enfermedad durante el periodo 2019 hasta 2023. Resultados. El tratamiento de la glomerulonefritis membranosa en pacientes de bajo riesgo se basa en la utilización de los ARA II o IECA para controlar la presión arterial y reducir la proteinuria con el objetivo de disminuir en un 20% la tasa de recaídas de la enfermedad, si no existe respuesta a la terapéutica se consideran opciones más agresivas como el tratamiento inmunosupresor mismo que aumenta la remisión total en un 73% y reduce el riesgo de presentar enfermedad renal terminal en un 22%. Conclusión. La eficacia de la terapéutica para la glomerulonefritis membranosa se basa en la combinación de una terapia inmunosupresora a base de esteroides más agentes alquilantes para evitar una mala tolerancia al tratamiento por parte del paciente nefrótico y disminuir las recaídas de la nefropatía membranosa. Área de estudio general: medicina. Área de estudio específica: medicina general.
Accuracy of Multi-Detector Computed Tomography In the Diagnoses of Adnexal Masses
Authors: Syeda Nurjahan Begum  , Most Razina Jubaida  , Nusrat Zahan  , Rubaiya Alam
Published: October 2023

Background: Ovarian cancer is the 5th common cause of death in women. patients older than 30 years are high malignant potential group. The lifetime risk of dying from invasive ovarian cancer is about 1 in 95. Modern imaging techniques have demonstrated significant accuracy in the diagnosis and staging of adnexal masses that help the clinician in surgical and post-surgical treatment planning. Objective: To determine the accuracy of multidetector computed tomography (MDCT) in diagnoses of benign and malignant adnexal masses, compare it with histopathological diagnoses and find out the sensitivity, specificity, positive predictive value, negative predictive value of MDCT in diagnoses of benign and malignant adnexal masses. Materials and Methods: This cross-sectional observational study was carried out between January 2013 to December 2014 with 45 patients referred for an MDCT scan of the pelvic organ with a suspicion of adnexal mass in Dhaka Medical College, Dhaka. All the patients were evaluated by detailed history and clinical examination. CT scan of the pelvic organ was performed in all cases and the report was checked by the radiologists of DMCH. Operated patients were followed up after surgery up to histopathological diagnosis and correlated with CT scan findings. Results: CT diagnosis for evaluation of benign adnexal mass, sensitivity was 90.0%, specificity 92.0%, accuracy 91.1%, PPV was 90.0% and NPV 92.0%. In the case of malignant mass, sensitivity is 92.0%, specificity 90.0%, accuracy 91.1%, PPV 92.0% and NPV 90.0%. Conclusion: MDCT is a valuable modality in the diagnosis of benign and malignant adnexal masses.KYAMC Journal Vol. 14, No. 02, July 2023: 74-78.
IKLIM KOMUNIKASI ORGANISASI
Authors: Muspawi Mohamad , Mika Mika , Viola Mayshel Adinda , Karmila Karmila
Published: October 2023

This study discusses the organizational communication climate. The purpose of this study is to be able to find out what is included in the scope of organizational communiction climate, which wiil then be described and explained in more detail. The method used in this study is aqualitative method with a literature study approach, while the literature used is by utilizing digital litecary and other data that contains the objct under study. The results of the research show that the organization is so important for human life and civilization in living theirdaily lives for fulfill their needs and desires, therefore it is very impotant for us to understand the organizational communication climate, so that formation and implementation of the organization formed can be done as well as possible. Furthermore, the main topic discussion in this study is the definition and concept of organizational communication climate, factors that influence organizational communication climate, the impact of organizational communication climate on organizational performance, improving organizational communication climate, and case studies or examples. Key Words: Organizational, Communication, Climate
METODE MENINGKATKAN PRESTASI BELAJAR SISWA PADA MATA PELAJARAN BAHASA ARAB DI MAN 1 SUMBAWA BARAT
Authors: Larassati Minten Ayu
Published: October 2023

Abstract : This study aims to reduce learning barriers so that efforts are obtained to improve children's learning achievement. which is a case study research, data collection is carried out by interview and document methods.Data analysis techniques were performed with miles and huberman models. Based on the results of data analysis, it shows that the obstacles in learning Arabic at MAN 1 West Sumbawa are;(1) students have not mastered the basic language of Arabic (2)Low mastery of Arabic vocabulary. (3) low student interest in learning (4)Students are strongly influenced by the environment outside the school, so students do not focus on learning and are affected by activities that are not needed in order to achieve learning goals. Solutions in improving student learning achievement, namely (1) students who have not mastered the basic knowledge of Arabic, namely with the teacher providing very basic learning materials and providing additional tasks to practice basic Arabic language skills (2) the teacher uses the method of mastering Arabic vocabulary starting from easy to difficult (3) using the memorization method (4) To increase students' low interest in learning teachers approach students emotionally by giving advice and motivation. It can be concluded that students' Arabic learning outcomes can be improved by the use of appropriate and good learning methods by teachers in the learning process at school. Key Words: Methods, Learning Achievements, Language Arabic.
ELAKSANAAN PEMASARAN JASA PENDIDIKAN DI MADRASAH IBTIDAYAH KURNIA ILAHI PULAU HARAPAN-BANYUASIN
Authors: Niswah Choirun , Ibrahim Ibrahim , Adinda Diah
Published: October 2023

Abstract: This research is entitled "Implementation of Educational Services Marketing at Madrasah Ibtidayah Kurnia Divine Pulau Harapan Village". This study aims to determine the implementation of marketing of educational services in Madrasah Ibtidayah KurniaDivine Pulau Harapan Village. The type of research used in this research is descriptive qualitative research. The data that has been obtained and collected is through observation, interviews, and documentation. This type of research approach is descriptive qualitative. The techniques used in analyzing the data are as follows, namely data reduction, data presentation and conclusion drawing. To test the validity of the research data using data source triangulation, technical triangulation, and time triangulation. From the results of the research that has been carried out, it shows that to be able to find out how the implementation of marketing of educational services at Madrasah Ibtidayah Kurnia Ilahi Desa Pulau Harapan. Running effectively and efficiently. Providing the best service and marketing products by utilizing social media and outreach. Deepen religious knowledge such as worship and reading the Koran. Identify all objective facilities and obstacles. The supporting factors are human resources and costs. On the other hand, the inhibiting factors are product and promotion. In addition to these factors contained in this discussion there are also indicators which are one of the activities that take place in the marketing of educational services at madrasah ibtidayah kurnia ilahi devine pulau harapan village, namely education customer satisfaction, aducation customer loyalty, and finally, public opinion in image educational institutions.Keywords: Implemention, Service Marketing, Education
CHAMBER-INSTRUMENTAL CREATIVE WORKS OF UKRAINIAN COMPOSERS OF THE LATE 20TH AND EARLY 21ST CENTURIES: AN EXPERIMENTAL DISCOURSE
Authors: DRUZHHA IRYNA , MANDZIUK LIUBOV , NOVYTSKYI KOSTIANTYN , VODOLIEIEVA NATALIA , PANASIUK IVAN
Published: October 2023

The study is devoted to the analysis of modern Ukrainian banduristics on the base of instrumental and vocal-instrumental music for bandura of the late 20th -21st centuries in the context of the latest performing and expressive means and techniques. The authors claim that among the varieties of modern musical content, bandura creativity is one of the most active and intensively developing areas, in particular, due to changes in the design of the instrument. One of the key theses of the article is that the rapid development of bandura music creativity in the second half of the 20th - 21st centuries is connected not only with the improvement of traditional ways of playing, but also with the expansion of the sphere of expressive possibilities of bandura due to the emergence of new performance techniques and means. Using the example of the work of modern Ukrainian composers, it is shown that modified traditional and modern means of expression are a relevant topic of modern banduristics. Nowadays, a concert bandurist has a significant set of technical tools in his arsenal, which make it possible to solve the multi-component tasks of reading the author's idea of a work.
PUBLIC ADMINISTRATIVE MODEL OF THE STATE SECURITY ENSURING SYSTEM OF UKRAINE
Authors: ZIUZIA OLEKSANDR
Published: October 2023

Attention is focused on the conceptual uncertainty in the critical issue of what should be the most optimal public administrative model for ensuring the state security of Ukraine in the current realities of the development of the strategic security environment. The article analyzes the national scientific achievements in the development of state security ensuring system of Ukraine as a fundamental public administration system which comprehensively covers, among other things, the state security sphere. Research of theoretical general methodological approaches to improving existing and developing new forms and methods of ensuring state security of Ukraine is presented, highlighting promising scientific and academic experience that can be useful for the development and improvement of the optimal public administrative model of ensuring state security of Ukraine. Considering the national scientific discourse on the categorical concepts of “state security”, “national security”, and “national security system”, the article examines the characteristics which should be inherent in a perfect system of ensuring state security, that should be developed in the Ukrainian State. The authors’ definition of the generalized concept of Ukraine’s security ensuring system is presented, considering the above analysis, and the critical tasks of Ukraine’s security ensuring system are detailed. Characteristic features of the state security system of Ukraine are identified: the system has to be manageable, observable, and identifiable; the system may contain destabilizing elements of subsystems; it is necessary to distinguish security levels based on the principle of their relative independence (“strategic-tactical-operational” or, for example, “national-district-regional-local” or “functional-sectoral”). Methodological approaches to developing a complementary public administrative model for ensuring the state security of Ukraine are proposed, which is intended to serve as a reliable tool for solving organizational and administrative tasks in the sphere of ensuring the state security of Ukraine.
Lehetne jobban?! – A háziorvosi teljesítmény értékelésének módszertani továbbfejlesztése
Authors: Pálinkás Anita , Vincze Ferenc , Kovács Nóra , Sipos Valéria , Czifra Árpád , Kolozsvári László Róbert , Rurik Imre , Sándor János
Published: October 2023

Bevezetés – Az alapellátás hatékonyságát a háziorvos (HO) egyéni jellemzőin és a praxis sajátosságain túl, általa nem befolyásolható tényezők határozzák meg, melyek figyelembevétele a jelenlegi hazai teljesítményértékelési rendszerben nem hang súlyos. Célkitűzés – Vizsgálatunkkal szerettük volna demonstrálni, hogy milyen módon egészítené ki a HO-i teljesítmények praxisjellemzőkkel korrigált értékelése a jelenleg működő értékelési rendszert. Módszer – A Nemzeti Egészség biztosítási Alapkezelő (NEAK) 12 indikátorának 2012. és 2018. évi adatait elemeztük. A HO-k szakmai teljesítményének értékeléséhez az ellátottak szociodemográfiai összetételére és a praxis elhelyezkedésére korrigált indikátorokat fejlesztettünk, és vizsgáltuk, hogy a betegek ellátottsága milyen mértékben függ a HO teljesítményétől. Eredmények – A praxisjellemzőkre korrigált indikátorok szerint a NEAK által kiemelt praxisok 43,5%-ának, illetve 21,8%-ának volt kiemelkedő a szakmai teljesítménye, az átlagos teljesítmények 19,1%-a, illetve 32,1%-a kapott többletfinanszírozást, míg a kiemelkedő teljesítmények 15,3%-át, illetve 27,9%-át nem ismerte el a NEAK pontrendszere. Megbeszélés – A jelenlegi rendszer alkalmas a betegek ellátottságának monitorozására, azonban az indikátorok sok esetben csak a kedvező adottságokat tükrözik, alulértékelve a kedvezőtlen helyzetű praxisok teljesítményét. Következtetés – A nyers és praxisjellemzőkre korrigált indikátorok együttes alkalmazása megalapozhatná azt a teljesítményértékelést, amire hatékonyabb intervenciók és teljesítményösztönző finanszírozási rendszer lenne építhető.