bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPAIRED CARBOHYDRATE METABOLISM IN KYRGYZ POPULATION: CASE REPORT
Authors: Rysbekova Gulnar , Mamatova Sabirakhan , Musaeva Begayim , Esengeldi kyzy Aizhamal , Shadab Azhar
Published: June 2024

Relevance. This case report presents a comprehensive analysis of impaired carbohydrate metabolism prevalence among Asian individuals in Kyrgyzstan. A dataset encompassing 223 patients aged between 25 and 73 years was scrutinized, revealing noteworthy insights into gender distribution, family history of diabetes mellitus, age demographics, body mass index (BMI) metrics, waist circumference, blood pressure readings, fasting glucose levels, and postprandial glucose concentrations. The findings underscore the imperative for targeted interventions and scientific strategies to tackle the escalating burden of impaired carbohydrate metabolism within this demographic.
Interval-Based Multi-Objective Planning for 5G Base Stations in Virtual Power Systems
Authors: Yuan Zhang
Published: June 2024

This article proposes a multi-objective interval collaborative planning method for virtual power plants and distribution networks. On the basis of in-depth analysis of the operational characteristics and communication load transmission characteristics of the base station, a virtual power plant 5G base station participating in the cellular respiration demand response model was constructed. A multi-objective interval optimization model for collaborative planning of virtual power plants and distribution networks has been established. The calculation results have verified the effectiveness of the method.
BUCCAL MUCOADHESIVE SYSTEM FORMED BY LIQUID CRYSTALS OF RASAGILINE MESYLATE FOR NON- ORAL PARKINSON TREATMENT
Authors: Güneş Meliha , Turan Gökçe , Masalcı Özgür , Özer Kevser Özgen , Karavana Sinem Yaprak
Published: June 2024

BUCCAL MUCOADHESIVE SYSTEM FORMED BY LIQUID CRYSTALS OF RASAGILINE MESYLATE FOR NON- ORAL PARKINSON TREATMENT
Meliha GÜNEŞ1, Gökçe TURAN1, Özgür MASALCI2, Özgen ÖZER1, Sinem Yaprak KARAVANA1*
ABSTRACT
The morning "off period" in individuals with Parkinson's disease (PD), characterized by challenges in receiving the appropriate dose for sleep, insufficient drug levels in the blood, and gastrointestinal issues, poses a significant challenge that impacts the overall quality of life for these patients. Based on research findings, these issues can be successfully addressed using non-oral treatments exclusively. Numerous mucoadhesive systems, such as lyotropic liquid crystals (LCs), have been identified. These systems can form an oblique connection with the buccal mucosa, thereby extending the residence time and optimizing drug bioavailability. The objective of this study is to prepare RM glyceryl monooleate/poloxamer 188 liquid crystal matrices (GMO/Plx188 LCs) to improve the bioavailability of RM. The structures of the prepared formulations were examined by polarized light microscopy and SAXS analyzed. These formulations were also evaluated for several parameter such as appearance, visualization, content uniformity, homogenity, viscosity, mucoadhesion. Obtained results demonstrates the prospective of liquid crytals as a viable and alternative approach for effective rasagiline mesylate buccal delivery.

KEYWORDS: Liquid Crystals, Rasagiline mesylate, Glyceryl Monooleate, Parkinson, Buccal delivery
Doğal Afet Riski Taşıyan Bölgelerde İşletme Yer Seçiminde Dikkat Edilmesi Gereken Faktörlere Dair Literatür İncelemesi
Authors: Kaya Akçaoğlu Neslihan , Tatlı Yasemin
Published: June 2024

İşletmelerin faaliyetlerini sürdürdüğü coğrafi yeri ifade eden kuruluş yeri bir işletmenin ayakta kalması ve sürdürülebilirliği için kritik öneme sahiptir. Sanayi tesisleri sadece kurucuların değil aynı zamanda ekonominin ve ülke refahının ana unsurlarındandır. Bu açıdan bakıldığında sanayi tesisleri sadece İşletme disiplininin değil ekonomik coğrafyanın da önde gelen inceleme alanları arasındadır. Ekonomi ve coğrafya açısından bakıldığında kuruluş yeri seçerken doğal afetler üzerinde durulması da önem arz etmektedir. Doğal afetlerin insanlar ve onların kurduğu yapılara etkisi insanın yeryüzündeki yaşam yolculuğu ile başlar. Tabii ki oluşum ve etkileri oluştuğu coğrafya ve zamana göre değişiklik göstermektedir. Dünyada olduğu gibi ülkemizde de afet riski taşıyan bölgelerde sanayi tesislerinin kurulacağı yerin neresi olacağı önemli bir karardır. Çünkü oluşabilecek afet tıpkı insanların yaşadığı konutları etkilediği gibi sanayi kuruluşlarının iş operasyonlarını ve varlıklarını ciddi şekilde etkileme potansiyeline sahiptir. Afet riski yüksek olan bölgelerde kuruluş yeri seçerken; bölgedeki jeolojik ve sismik riskler, iklimsel tehditler, mevcut su kaynakları ve sel riskleri, yangın riski, toprak kaymaları ve heyelanlar, tsunami riski, fırtına ve hortumlar, bölgenin altyapısı ve ulaşım imkânları, sigorta ve acil durum planları, yerel yönetmelikler ve izinler ve topluluk ilişkileri dikkate alınması gereken faktörler arasındadır. Çalışmada afet riski yüksek olan bölgelerde yer seçimi yaparken hangi faktörlere dikkat edilmesi gerektiği ve iyi uygulama örneklerine değinilecektir.
SYNTHESIS/SYNLETT Best Paper Awards 2023
Authors: Mukherjee Santanu , Sato Takaaki
Published: June 2024

Thieme Chemistry and the editors of SYNTHESIS and SYNLETT present the "[SYNTHESIS/SYNLETT Best Paper Awards](https://www.thieme.de/de/thieme-chemistry/journals-synthesis-synlett-best-paper-awards-72162.htm)" to honor outstanding research in chemical synthesis. In this Thieme Cheminar, our speakers will present their research related to their award-winning articles which can be read [here](https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1941-8680) and [here](https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1912-3216).

Our line-up:

- Takaaki Sato (Japan) – “Total Synthesis and Anti-inflammatory Activity of Stemoamide-Type Alkaloids”
- Santanu Mukherjee (India) – “Breaking Symmetry: Reaction Development Application to Complex Targets”

Don't miss this opportunity to gain insights from leading scientists and learn about the latest advances in synthetic chemistry. RSVP above to save your spot!

Breaking Symmetry: Reaction Development & Application to Complex Targets

Human minds are fascinated by symmetrical objects, and we admire the challenges in constructing them. In contrast to the physical world, we live in, creating symmetry in the molecular world is a relatively simple task. It is the daunting asymmetry in molecules that often challenges the chemists.

Breaking symmetry to generate asymmetry, known as desymmetrization, is a remarkably powerful strategy for building molecular complexity. Successful implementation holds the potential to forge multiple stereogenic centers, even away from the reaction site, in a single step.

During the past few years, we have developed a number of organocatalytic enantioselective desymmetrization reactions, including a formal C-H alkylation. This talk will be primarily confined to the enantioselective formal C-H alkylation and its applications to the synthesis of complex targets.

Total Synthesis and Anti-inflammatory Activity of Stemoamide-Type Alkaloids

The stemoamide-type alkaloids have received considerable attention due to recent biological studies involving anti-inflammatory effects such as LPS-induced acute lung injury in mice. However, the structural complexity including pentacyclic scaffold prevents demonstration of the structural activity relationship. We achieve the collective total synthesis of the stemoamide-type alkaloids based on three key methods: 1) chemoselective assembly of five-membered rings, 2) stereodivergent construction of totally-substituted butenolides, and 3) direct oxidation of pyrrolidines. These methods enabled us to determine the systematic SAR, revealing that the pentacyclic framework including the totally substituted butenolide is crucial for anti-inflammatory activities.
Outcome Comparison between Carpometacarpal Arthroplasty and Trapeziectomy in Patients with Carpometacarpal Osteoarthritis: A Systematic review
Authors: Hidajat Nucki Nursjamsi , Aditya Rio , Arsa Widya , Malik Realita
Published: June 2024

Background

Osteoarthritis of the carpometacarpal (CMC) is considered a common musculoskeletal disorder. The treatment of carpometacarpal osteoarthritis could be either by conservative or surgical methods. surgical treatment, there are various alternatives, including trapeziectomy and arthroplasty. This study aims to perform a systematic review of the literature to determine the functional outcomes associated with trapeziectomy and arthroplasty in CMC arthritis.

Objectives

To determine the functional outcomes associated with trapeziectomy and arthroplasty in CMC arthritis patients.

Methods

A systematic review was conducted according to PRISMA guidelines and performed on August 2022 by one independent reviewer (author) using PubMed database, EBSCO Host, EMBASE, and ScienceDirect. The literature search will be based on Patients, Intervention, Control, and Outcome (PICO) criteria, as mentioned in the following: Patients with any carpometacarpal arthritis; with the intervention of using carpometacarpal arthroplasty as their method of surgery; control with trapeziectomy and primary outcome of functional outcome. Clinical outcomes using patient-reported outcome measures and complications were included. The quality of the included studies was evaluated with Cochrane risk-of-bias assessment tools. Quantitative analysis was performed by Review Manager 5.4.

Results

Three studies met the inclusion criteria for the systematic review. Both treatments resulted in significant improvements in functional scores. When matching patients according to preoperative function, patients receiving arthroplasty had better postoperative function (Quick DASH: trapeziectomy = 25.1, ARPE = 16.8).

Conclusion

This study showed that variable results of clinical outcomes improved after trapezeictomy and arthroplasty in patients with CMC arthritis. Evidence showed that arthroplasty allows for a better improvement in functional outcome.
Femorotibial angle on short knee radiographs fails to accurately predict the lower limb mechanical alignment. A systematic review and meta-analysis on different femorotibial angle definitions and short knee radiograph types
Authors: Giurazza Giancarlo , Perricone Giovanni , Franceschetti Edoardo , Campi Stefano , Gregori Pietro , Zampogna Biagio , Cardile Umberto Gabriele , Papalia Giuseppe Francesco , Papalia Rocco
Published: June 2024

Introduction

Hip-knee-ankle angle (HKA) on Full Limb Radiographs (FLRs) is the gold standard for coronal knee alignment assessment. Despite the widespread utilization of the more convenient femorotibial angle (FTA) on either antero-posterior (AP) or postero-anterior (PA) short knee radiographs (SKRs), its definition and correlation with HKA remains controversial. This review is the first to systematically investigate FTA-HKA correlation and the effect of different FTA methods and SKRs.

Methods

Systematic literature search (Pubmed, Scopus, Cochrane Library) followed PRISMA guidelines, to evaluate studies examining the FTA-HKA correlation. Meta-analyses compared the 3 most common FTA methods, knee center determination method and SKR types.

Results

17 studies (2597 patients, 3234 knees) were included. The strongest correlation with HKA (r = 0.78) was found for FTA Method 1 (angle formed by lines drawn from the midpoint of tibial spines to points 10 cm above and below the joint line). No significant differences were observed when grouping the FTA methods by knee center assessment (Group I, r = 0.78; Group II, r = 0.77). AP SKRs showed a trend towards stronger FTA-HKA correlation compared to PA SKRs, in both Method 1 (r = 0.79 vs 0.75) and Method 3 (r = 0.80 vs 0.66).

Conclusion

Irrespective of its definition or type of SKR used, FTA lacks reliable accuracy in predicting the HKA in most knees. FLRs should be used whenever precise estimation of the patient’s alignment is necessary. Caution is warranted in interpreting studies investigating knee alignment or knee arthroplasty outcomes based on FTA.
Healthcare Workers Knowledge and Practice about Adverse Drug Reaction Reporting and Pharmacovigilance in Zaria, North-West Nigeria
Authors:   Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Benin, Benin City, Edo State, Nigeria, Odiba O. , Aghahowa S. E. ,   Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Edo State, Nigeria, Aghahowa M. E. ,   Department of Surgery, Asokoro District Hospital, Abuja Nigeria
Published: June 2024

Background: Pharmacotherapy aims to optimize patient care by increasing drug efficacy and reducing drug toxicity. However, this goal is not always achieved particularly when adverse drug reaction (ADR) occurs. Globally, knowledge and practice of pharmacovigilance has enhanced health-care systems in recent times. Despite this, there are limitations in some regions. Objectives: The study aimed to investigate the knowledge and practice about adverse drug reaction reporting and pharmacovigilance among health workers in healthcare facilities in Zaria, North-west Nigeria Methods: A descriptive cross-sectional survey was conducted using structured questionnaires. These were distributed among 453 health workers in two tertiary hospitals, two secondary hospital, twelve primary health-care centers and twenty-three community pharmacies. The results were analyzed using descriptive and inferential statistical analysis. Results: Of the 453 respondents, male/female ratio was 1:1.1, 62% had heard of pharmacovigilance though only 29% correctly defined it. Participants were mainly Nurses (39.5%) and Doctors (25%). About 75% knew the meaning of ADR reporting, 54% knew about existence of pharmacovigilance in Nigeria and 35.32% agreed that all workers should report ADRs. Only 40% agreed that there was an existing reporting system and 65% send reports to pharmacists. A significant difference in knowledge and level of practice of ADR reporting (P = 0.0001) exists. Ignorance (63%) and negative perception (46%) by the professionals were the main reasons for low ADR reporting. Conclusion: The results showed that an appreciable number of respondents had sufficient knowledge and practice of pharmacovigilance. The study recommends that stakeholders should intensify efforts in strengthening pharmacovigilance practice.
Original method for evaluating the microcirculatory bed of the peripapillary optic nerve head in primary open-angle glaucoma
Authors: Fomin N. E. , Kuroyedov A. V. , Arkharov M. A. , Prokhorenko V. V.
Published: June 2024

PURPOSE. To study the state of microcirculation in the peripapillary region of the optic nerve head (ONH) using an original method of objective assessment in the absence of the necessary licensed software.

METHODS. A total of 30 patients (30 eyes) were included. The main group consisted of patients with early (subgroup 1, 10 eyes) and advanced (subgroup 2, 10 eyes) stages of primary open-angle glaucoma (POAG), the control group — individuals without history of ophthalmic complications (10 eyes). The peripapillary region of the ONH was examined using optical coherence tomography angiography (OCT-A). An original script was written in Python language for assessment of the prevalence of the vascular bed on the scans, analyzing an array of elements with brightness data.

RESULTS. Subgroup 2 differed most from subgroup 1 in capillary deficiency in the superficial layer. Differences between the groups were found in the capillary network density in the superficial and deep vascular plexuses, in the superficial layer they were statistically significant (subgroup 1 — 27444.5±1372.2; subgroup 2 — 14126.5±706.3; control group — 45198.5±2259.9). Correlation analysis in advanced glaucoma confirmed almost complete atrophy of the superficial layer, which became almost "transparent" to the device.

CONCLUSION. The developed method, based on the capabilities of OCT-A and additional machine analysis, can be used in the complex diagnostics of POAG both to confirm the stage of the pathological process and to assess the effectiveness of the ongoing therapeutic measures.
BORSA İSTANBUL’DA İŞLEM GÖREN SPOR KULÜPLERİNİN FİNANSAL PERFORMANSLARININ GRİ İLİŞKİSEL ANALİZ YÖNTEMİYLE İNCELENMESİ
Authors: Balçıklı Soner , Kocabıyık Turan
Published: June 2024

Bu çalışmanın amacı Borsa İstanbul’da işlem gören spor kulüplerinin ilişkili olduğu sportif şirketlerin finansal performanslarının incelenmesidir. İnsanların boş vakitlerini değerlendirmesi için yapılan hareketleri ifade eden spor günümüzde büyüyen ekonomi boyutu ile de ön plana çıkmaktadır. Spor ekonomisinin büyümesi spor kulüplerine de etki etmiştir. Çalışmada Türkiye liglerinde bulunan kulüplerden Borsa İstanbul’da işlem gören Beşiktaş, Fenerbahçe, Galatasaray ve Trabzonspor kulüplerinin 2016 – 2020, yıllık mali tabloları ile piyasa verileri finansal performans kapsamında analiz edilmiştir. Finansal verilerden hesaplanan finansal oranlar ve yatırım şirketlerinden alınan piyasa oranları Critic modeli ile ağırlıklandırılmış Gri İlişkisel Analiz yöntemi ile incelenmiştir. Çalışma sonucunda kulüplerin finansal performans sıralaması Fenerbahçe, Galatasaray, Trabzonspor ve Beşiktaş şeklinde oluşmuştur.
THE POLITICS OF BUILDING CIVIL SOCIETY IN THE SOUTH CAUCASUS: A HISTORICAL OVERVIEW OF GEORGIA AND ARMENIA
Authors: Doğan Muharrem , Sırmalı Gökhan
Published: June 2024

This study discusses the development of civil society in Georgia and Armenia after the collapse of the USSR. Both countries in the South Caucasus have unique achievements in civil society activism, but in some ways, they share the same patterns. International donors and foreign assistance have played a crucial role in the development of civil society in both countries. International actors have tried to support civil society activism in these ex-Soviet countries to strengthen democratic values, beliefs, and institutions. While the Georgian ruling elites opened a new dimension of civil society, the Armenian elites did not respond in a way that created space for the development of civil society. One of the main reasons for this is that Armenian civil society has been characterised by the Karabakh issue and the Armenian diaspora has controlled civil society activism for many years. In contrast, relations with the West have become inherent in Georgia, opening up new avenues for the development of civil society.
TÜRKİYE’DE KONUT SATIŞLARINI ETKİLEYEN FAKTÖRLERİN YERLİ VE YABANCILAR AÇISINDAN İNCELENMESİ
Authors: Ünlü Mustafa
Published: June 2024

Kişilerin konut taleplerini oluşturan iki temel etkenin barınma ihtiyacı ve yatırım olduğu bilinmektedir. Barınma ihtiyacını gerçekleştirmek için yapılan konut alımları da aslında bir yatırım olarak değerlendirilebilir. Buna ek olarak yatırımcılar da yerli ve yabancı olmak üzere iki kategoriye ayrılabilir. Ekonominin genel durumunda meydana gelen değişimler, bu yatırımcı grupları arasında farklı etkiler yaratabilir. Çalışma kapsamında yerli ve yabancılara yapılan konut satışlarını etkileyen faktörler ayrı modellerle incelenmiştir. 2013 Ocak ve 2023 Haziran dönemi aylık verileri kullanılarak gerçekleştirilen analizlerde yabancıların konut alımlarını etkileyen faktörler tüketici fiyat endeksi, TL/Dolar kuru ve gram altın TL fiyatları olarak belirlenmişken; yerliler için bu faktörlere ek olarak konut kredisi faiz oranları da ilgili modele dahil edilmiştir. Eşbütünleşme ilişkisinin varlığı otoregresif dağıtılmış gecikme (ARDL) modeli kullanılarak analiz edilmiştir. Elde edilen sonuçlara göre her iki model de eşbütünleşme ilişkisinin var olduğu tespit edilmiştir. Hem yerli hem de yabancılar için tüketici fiyat endeksinin konut alımı üzerinde negatif etkisinin olduğu, yine her iki modelde de dolar kurunun konut alımını artırdığı görülmüştür.
TÜRKİYE’DE REEL DÖVİZ KURU İLE EKONOMİK BÜYÜME İLİŞKİSİ
Authors: Kofoğlu İsmail Hakkı , Alaca Zühal
Published: June 2024

Bu araştırmada Türkiye’de reel döviz kuru ile ekonomik büyüme ilişkisi, 2006Q1- 2023Q2 dönemi için üç aylık verilerle araştırılmıştır. Araştırmada reel döviz kurunu temsilen Reel Efektif Döviz Kuru Endeksleri ve büyümeyi temsilen 1998 sabit fiyatlı Gayri Safi Yurtiçi Hasıla değerleri kullanılmıştır. Araştırmada uzun dönemli ilişkiler Gecikmesi Dağıtılmış Oto Regressif eşbütünleşme yöntemiyle ve kısa dönemli ilişkiler Hata Düzeltme yöntemiyle belirlenmiştir. Eşbütünleşme analizine göre değişkenler eşbütünleşik belirlenmiş ancak, uzun dönem katsayıları istatistiksel olarak anlamsız bulunmuştur. Hata düzeltme modeli bulgularına göre tüm değişkenlerden büyümeye doğru nedensellik belirlenmiş ancak kısa dönem katsayıları işaret olarak değişkenlik göstermiştir. Reel efektif döviz kuru endeksleri ile ekonomik büyüme uzun dönemde eşbütünleşik ancak, uzun dönem katsayısı istatistiki olarak anlamsız çıkmıştır. Kısa dönem ilişkisinde reel efektif döviz kuru endeksleri ile büyüme arasında negatif yani ters yönlü bir nedensellik ilişkisi belirlenmiştir. Özel olarak ifade etmek gerekirse, reel efektif döviz kuru endeksleri yükseldiğinde yani Türk Lirası değer kazandığında ekonomik büyüme olumsuz etkilenmekte, buna karşılık reel efektif döviz kuru endeksleri düştüğünde yani Türk Lirası değer kaybettiğinde ekonomik büyüme olumlu etkilenmektedir. İstatistiki olarak uzun dönemde yüzde beş anlamlılık düzeyinde reel döviz kuru büyümenin doğrudan belirleyicisi değildir. Kısa dönemde ise büyüme ile reel efektif döviz kuru endeksleri arasında yüzde on anlamlılık düzeyinde endeks değerlerinden büyümeye doğru tek yönlü nedensellik tespit edilmiştir. Buna göre kısa dönemde reel döviz kuru büyümeyi etkilemesi zayıf derecede olmaktadır. Bu sonuçlara göre reel döviz kurunun büyümeye olumlu katkısının olabilmesi için dış ticarette ihracatı artıran, ithalatı azaltan ve doğrudan yabancı sermaye girişlerini teşvik eden rekabetçi bir kur politikası izlenmelidir.
PERAN KELOMPOK TANI DALAM MENINGKATKAN PRODUKTIVITAS USAHA TANI PADI SAWAH DI DESA RANOIAPO
Authors: Kairupan Alin Juliana , Taroreh Johny , Rattu Febriyanti
Published: June 2024

ABSTRAK
Penelitian ini bertujuan untuk mengetahui bagaimana peranan kelompok tani dalam peningkatan produktivitas usaha tani padi seta apa saja hambatan kelompok tani dalam peningkatan produktivitas usaha tani padi sawah di Desa Ranoiapo. Metode penelitian ini menggunakan metode kualitatif dengan instrument penelitian seperti wawancara, adapun yang menjadi objek dalam penelitian ini adalah Kelompok tani dan para Petani di Desa Ranoiapo. Hasil penelitian menunjukkan bahwa penting Peran kelompok tani di Desa Ranoiapo dapat tergambarkan dari produktivitas usaha tani yang meningkat, hadirnya kelompok tani juga dapat dijadikan sebagai mitra para petani untuk saling bertukar informasi dan belajar terkait pertanian, disisi lain terdapat beberapa hambatan yang dihadapi oleh kelompok tani seperti permasalahan pasokan pupuk dan benih yang sering terjadi yaitu kurangnya dan keterlambatan pasokan pupuk dan benih dari para mitra kelompok tani selain permasalaha pupuk dan benih modal juga menjadi masalah yang sering dihadapi oleh para petani.
Kata Kunci: Peranan, Kelompok Tani, Produktivitas Usaha Tani.
 
 
 
 
 
ABSTRACT
This research aims to find out the role of farmer groups in increasing the productivity of rice farming and what obstacles farmer groups have in increasing the productivity of rice farming in Ranoiapo Village. This research method uses qualitative methods with research instruments such as interviews. The objects of this research are farmer groups and farmers in Ranoiapo Village. The results of the research show that the important role of farmer groups in Ranoiapo Village can be illustrated by the increased productivity of farming businesses, the presence of farmer groups can also be used as partners for farmers to exchange information and learn related to agriculture, on the other hand there are several obstacles faced by farmer groups such as Fertilizer and seed supply problems that often occur, namely the lack and delay in the supply of fertilizer and seeds from farmer group partners, apart from capital fertilizer and seed problems, are also problems often faced by farmers.
Keywords: Roles, Farmer Groups, Farming Business Productivity
PENGARUH KOMPETENSI MENGAJAR GURU DAN MOTIVASI BELAJAR TERHADAP KEMAMPUAN BELAJAR SISWA SMA NEGERI 1 MODOINDING
Authors: Tamboto Henry
Published: June 2024

Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh  kompetensi guru dan motivasi belajar  siswa terhadap  kemampuan belajar siswa SMA Negeri 1 Modoinding. Sampel dalam penelitian berjumlah 49 siswa.  Hasil analisis data menunjukkan bahwa berdasarkan hasil komputasi data dietmui bahwa koefisien korelasi berada diatas sebesar 0,220. Dalam menentukan koefisien determinan dilakukan untuk menentukan besar kontribusi Kompetensi  guru dan motivasi belajar siswa terhadap Kemampuan belajar siswa dengan menggunakan rumus KD = r2 x 100% = 0,220 x 100% = 22,0 % dengan demikian besar kontribusi kompetensi  guru dan motivasi belajar siswa terhadap kemampuan belajar siswa adalah 22,0%. Berdasarkan hasil uji diatas, dapat dilihat f hitung sebesar 6,701 > f tabel sebesar 3,200 dengan demikian Kompetensi guru dan motivasi belajar siswa terhadap Kemampuan belajar siswa secara simultan berpengaruh terhadap Kemampuan belajar siswa.
Kata Kunci : Kompetensi Mengajar guru, Motivasi Belajar,  Kemampuan Belajar Siswa
EFFECTS OF SOIL pH AND ORGANIC MATTER ON THE ACCUMULATION OF CADMIUM IN THE GRAINS OF SALT TOLERANT RICE GENOTYPES GROWN IN Cd CONTAMINATED SOIL
Authors: Hossain Mohammad Zaber , Islam Md. Azharul , Kibria Khondokar Qudrata , Md Atikul Islam
Published: June 2024

Cadmium (Cd) poses a serious threat to the environment and its concentration in rice grain causes significant dangers to people’s health. However, the effects of soil pH and organic matter (OM) on the accumulation of Cd in salt-tolerant rice genotypes under Cd stress remain unknown. In this study, separate pot experiments were conducted under Cd stressed soil (5 mg kg-1) with variations in soil pH and OM for the growth of rice plants. The study includes three pH (4, 7 and 9) and OM levels (1%, 2% and 3%). Under these conditions, the bioavailability of Cd in soil and its subsequent entry into the grain of rice genotypes were examined. Cd translocation from soil to the grain was compared among non-salt tolerant varieties (BRRI 28 and Heera) and salt-tolerant varieties (BRRI 67 and BRRI 47). The associated health risk assessment was also undertaken. All rice genotypes absorbed more Cd from soil and accumulated it in their grain when grown under low pH soil conditions. With increasing soil pH, grain Cd deposition declined significantly (p ≤0.05) in the order of Heera, BRRI 28, BRRI 67 and BRRI 47. Among the varieties a marked variation was obtained in the Cd absorption by each plant. OM addition in soil at a rate of 2% greatly reduced Cd accumulation in the grain of rice genotypes. A noticeable reduction was found in non-salt tolerant varieties over salt-tolerant genotypes. The hazard quotient (HQ) of Cd for both adults and children revealed the highest values at low soil pH conditions. Significant reductions in HQ values occurred in grain grown with OM only in non-salt-tolerant varieties. The result means that lower soil pH favors the accumulation of Cd in rice. Furthermore, grain Cd in rice genotypes can be reduced thorough the modification in soil bioavailable Cd and OM application in soil.
PLANT GROWTH, FRUIT YIELD, AND QUALITY OF CAPSICUM (CAPSICUM ANNUM L.) AS AFFECTED BY NITROGEN LEVELS IN THE COASTAL SOIL OF BANGLADESH
Authors: Nahida Nusrat , Khan Shamim Ahmed Kamal Uddin , Díaz-Pérez Juan C. , Kabir Md. Yamin
Published: June 2024

Though capsicum (Capsicum annum L.) is a high-value crop in Bangladesh, limited cultivation is reported in the coastal zone of Khulna. Moreover, the nitrogen (N) requirement of capsicum for this zone needs to be evaluated. An experiment was administered at the Agrotechnology Field Laboratory of Khulna University, Bangladesh, from 1st December 2020 to 25th March 2021 with the variety ‘California Wonder’ to evaluate the effect of nitrogen on plant growth, fruit yield, and the quality attributes of capsicum. The experiment was fixed following Randomized Complete Block statistical design with five levels of nitrogen (0, 58, 87, 116, and 145 kg N ha-1) and replicated four times. The recommended dose (116 kg N) and the highest dose (145 kg) of N resulted in statistically similar stem diameter, leaf number, leaf chlorophyll index (SPAD readings), yield, fruit diameter and length, vitamin C, and total soluble solid (TSS). Only plant height was statistically higher with the highest N level compared to the recommended level of N. However, numerically higher leaf number, chlorophyll index, yield and vitamin C content were recorded from the recommended dose of N and importantly, the recommended level of N resulted in 12% higher yield compared to the highest dose of N. Therefore, the application of 116 kg N ha-1 can achieve the optimum yield of capsicum in the Khulna region, and excessive N application did not increase the yield of bell pepper. However, more experiments should be conducted to recommend the optimal nitrogen dose for capsicum cultivation in the Khulna region of Bangladesh.
Janus Kinases and Autoimmunity: Bridging Pathways to Therapy
Authors: Wei Yazi , Zhang Tiantai
Published: June 2024

Review
Janus Kinases and Autoimmunity: Bridging Pathways to Therapy

Yazi Wei 1, and Tiantai Zhang 1,*

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China
* Correspondence: ttzhang@imm.ac.cn
 
Received: 7 February 2024; Revised: 1 March 2024; Accepted: 1 March 2024; Published: 5 June 2024
 
Abstract: Janus kinase (JAK) is a family of intracellular non-receptor tyrosine kinases with four members (JAK1, JAK2, JAK3, and Tyk2). The JAK-STAT (signal transducer and activator of transcription) pathway is an evolutionary conserved mechanism of transmembrane signal transduction relaying over 50 cytokines signals to regulate the proliferation, immune response, inflammation, and malignancy. The dysfunction of JAK-STAT signaling pathway is directly associated with the pathogenesis of inflammatory and autoimmune disorders, as well as tumor progression. Studies have shown that targeting the JAK family with small-molecule inhibitors can treat inflammatory and autoimmune diseases and myeloproliferative neoplasms. In this review, we discuss the current understanding of the JAK-STAT signaling and approved JAK inhibitors.
Integrins as Drug Targets in Vascular and Related Diseases
Authors: Meredith Emily , A. Schwartz Martin
Published: June 2024

Review
Integrins as Drug Targets in Vascular and Related Diseases

Emily Meredith 1,*, and Martin A. Schwartz 1,2,3
1  Yale Cardiovascular Research Center, Department of Internal Medicine (Cardiology), Yale University School of Medicine, New Haven, CT 06511, USA, martin.schwartz@yale.edu
2  Department of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.
3  Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
* Correspondence: Emily.meredith@yale.edu

Received: 6 April 2024; Revised: 28 May 2024; Accepted: 29 May 2024; Published: 21 June 2024

Abstract: Integrins are transmembrane receptors that, as critical participants in a vast range of pathological processes, are potential therapeutic targets. However, in only a few cases has the promise been realized by drug approval. In this review, we briefly review basic integrin biology and participation in disease, challenges in the development of safe, effective integrin-targeted therapies, and recent advances that may lead to progress.
UNet and Variants for Medical Image Segmentation
Authors: Ehab Walid , Huang Lina , Li Yongmin
Published: June 2024

Article
UNet and Variants for Medical Image Segmentation

Walid Ehab, Lina Huang, and Yongmin Li *

Department of Computer Science, Brunel University London, Uxbridge, UB8 3PH, United Kingdom
* Correspondence: yongmin.li@brunel.ac.uk
 
 
Received: 22 September 2023
Accepted: 25 December 2023
Published: 26 June 2024
 

Abstract: Medical imaging plays a crucial role in modern healthcare by providing non-invasive visualisation of internal structures and abnormalities, enabling early disease detection, accurate diagnosis, and treatment planning. This study aims to explore the application of deep learning models, particularly focusing on the UNet architecture and its variants, in medical image segmentation. We seek to evaluate the performance of these models across various challenging medical image segmentation tasks, addressing issues such as image normalization, resizing, architecture choices, loss function design, and hyperparameter tuning. The findings reveal that the standard UNet, when extended with a deep network layer, is a proficient medical image segmentation model, while the Res-UNet and Attention Res-UNet architectures demonstrate smoother convergence and superior performance, particularly when handling fine image details. The study also addresses the challenge of high class imbalance through careful preprocessing and loss function definitions. We anticipate that the results of this study will provide useful insights for researchers seeking to apply these models to new medical imaging problems and offer guidance and best practices for their implementation.
Time Perspective-Enhanced Suicidal Ideation Detection Using Multi-Task Learning
Authors: Yang Qianyi , Zhou Jing , Wei Zheng
Published: June 2024

Article
Time Perspective-Enhanced Suicidal Ideation Detection Using Multi-Task Learning

Qianyi Yang 1, Jing Zhou 1,*, and Zheng Wei 2

1 School of Computer and Cyber Sciences, Communication University of China, Beijing 100024, China
2 Zhongxing Telecommunication Equipment Corporation, Shenzhen 518057, China
* Correspondence: zhoujing@cuc.edu.cn
 
 
Received: 25 October 2023
Accepted: 5 March 2024
Published: 26 June 2024
 

Abstract: Suicide notes are written documents left behind by suicide victims, either on paper or on social media, and can help us understand the mentality and thought processes of those struggling with suicidal thoughts. In our preliminary work, we have proposed the use of Time Perspective (TP), which takes into consideration how people think of or appraise their past, present, or future life would shape their behavior, in suicide tendency detection based on suicide notes. The detection result is highly dependent upon a ternary classification task that groups any suicide tendency into one of the three pre-defined types. In this work, we define the suicidal emotion trajectory, a concept that is based on TP and used for depicting the dynamic evolution of an individual's emotional state over time, and this trajectory serve as an auxiliary task to the primary ternary classification task for a multi-task learning model, i.e. TP-MultiBert. The model features Bidirectional Encoder Representation from Transformer (BERT) components, replacing its counterpart, i.e., GloVe, in the previous model. Thanks to its desirable capability of understanding word contextual relationships, as well as multi-task learning capability of leveraging complementary information from various tasks, BERT shows promissing results in further improving the performance of suicide ideation detection.
“A Meditation Among Drums”: A Black Archive of Wandering at the Milford Graves: Fundamental Frequency Exhibit
Authors: Alonge Kehinde
Published: June 2024

This article follows my firsthand encounter with the Ars Nova Workshop and Artist Space's collaborative exhibit, Milford Graves: Fundamental Frequency, to fully engage with the question of how one might construct, or perhaps, more appropriately, deconstruct, an archive away from its typical neoliberal function to allow the propagation of “Black wandering” (explicitly thinking with and through Sarah Cervenak's use of the term “wandering”), whereby unrelenting subjectivity and disjunctive practices in temporality persist. As I navigated the visual and aural rubbings produced by the trove of Graves's life's ephemera, audio recordings, interviews with Marvin X, and heart monitor research, it remains clear that both his life and his music's experiential qualities, steeped in disorientation and dispersal, exceed the hold of the mediums that contain them, as they still exude a capacity in their arranged juxtapositions to produce what Baraka calls free jazz's “new thing.” Therefore, this article contends Graves's archive maintains a space by which, even in his passing, his sound and being can “reemerge as a new thing,” thus offering him futurity not predicated upon a corrected closure in the gap between the past and present but rather one forged by the disjunctive synthesis of moments that encourages those wandering amid its sonorous space to improvise their listening practices alongside Graves's unceasing improvisation, in indeterminate directions.
A Study on Classification of Business Types for Public Design Promotion
Authors:   Korea Society of Public Design, Seol Yeong-dong , Jang Young-ho
Published: June 2024

Today, it is difficult to think of the public sphere, daily life, and community life without thinking of public design. As public design is actively linked and grafted with various fields, it is spreading to all phenomena of public policy and society, expanding the scope of new business opportunities. Therefore, this study aims to present a typology of public design projects by examining the terrain of public design projects from a multidimensional perspective, which is a collection of processes and outcomes carried out for the purpose of individual and social needs, and ultimately accepted by the public as a socio-cultural experience. In line with the purpose of the study, the need for research on public design project types was confirmed through a review of previous studies and literature, and project types were categorized through case analysis of projects by the Ministry of Culture, Sports and Tourism and Seoul Metropolitan Government. As a result, four types of public design projects are proposed based on the orientation of thematic and practical methods: value creation, culture diffusion, capacity building, and foundation creation. At a time when a way of understanding public design projects that can be shared by various actors in implementation, participation, and cooperation needs to be established, the more comprehensive conceptualization of project types presented in this study is expected to provide direction in planning and implementing policies and projects, as it can be combined and linked to various areas such as culture, tourism, welfare, pedestrianism, safety, and health, as well as the design field.
A Study on the Design of AR-HUD(Head-up display) Interface Based on Situation Awareness
Authors:   Korea Society of Public Design, Wu Zhuo-Xun , Song Ji-Sung
Published: June 2024

With the development of intelligentization of the vehicle industry, cars are no longer just means of transportation, and various sensors and virtual entertainment systems have begun to be applied for autonomous vehicles and smart cars. Rise of in-vehicle information required by the new intelligent interaction method for information processing theory, this study has see car - human interaction interface based on AR technology introducing, driving experience and can improve the driving safety is studied interface design. To this end, literature research, case comparative analysis, and surveys were conducted, and comparative analysis was conducted on Tesla HUD and Huawei AR-HUD. In addition, through in-depth investigation of contextual user demands, it analyzed existing problems and proposed optimization of AR-HUD interface design based on situational awareness from three aspects of function, interaction and vision. Study driver's driving experience, improve driving stability, AR - propulsion, smart and personalization of HUD interface design intelligent vehicles and vehicles of the self-driving car and future improvement and theoretical foundation for design of an interface by providing drivers contributing to meet demand.
A Study on the Generation of Visual Images for Mythological Legends Using AI Generated Content(AIGC): Focusing on the Chinese Mythology Collection “Classic of Mountains and Seas” with ChatGPT and Midjourney
Authors:   Korea Society of Public Design, Zhao Zi-Yun , Song Ji-Sung
Published: June 2024

This study aims to utilize AIGC(AI Generated Content) technology, specifically employing ChatGPT-4 and Midjourney 6.0 as the primary tools, to design and generate visual images for the Chinese mythology collection “Classic of Mountains and Seas.” In the theoretical background section, the principles of AIGC and its service architecture are elaborated upon, with a detailed account of the development trajectories of ChatGPT and Midjourney. Subsequently, an analysis of the structural framework of “Classic of Mountains and Seas” and the basic characteristics of its mythological creatures provides the theoretical foundation for the experimental design. In the experimental design section, specific experimental steps are formulated by analyzing the advantages of ChatGPT and Midjourney. The processes of prompt input, image generation, and result evaluation are meticulously described. The experimental results indicate that ChatGPT-4 and Midjourney 6.0 can generate highly realistic and artistically rich visual images, effectively reproducing the classic imagery of the “Classic of Mountains and Seas.” However, challenges remain in handling complex mythological texts and intricate details, necessitating designer assistance to enhance accuracy. This study demonstrates the potential of AIGC in mythological art creation, paving a new path for the contemporary expression of traditional culture.
Psychometric properties of the Hikikomori Risk Inventory (HRI-24)in Turkish Pre-adolescents and Adolescents
Authors: ak Meryem , tl Hakan , an U , p Esra , Loscalzo Yura
Published: June 2024

Objective: Hikikomori, a severe social withdrawal condition, has become increasingly important in Western societies. The HRI-24 is a new tool for assessing Hikikomori risk in Eastern and Western samples with good psychometric properties. This study aimed to evaluate the psychometric properties of the Turkish version of the HRI-24 in pre-adolescents and adolescents.
Method: We recruited 600 pre-adolescents and adolescents (clinic sample = 265, community sample = 335) aged between 12 and 18 years. They filled the HRI-24, the Brief Sensation Seeking Scale (BSSS-4), and the Strengths and Difficulties Questionnaire (SDQ).
Results: Confirmatory factor analysis supported the five-factor model of the HRI-24 Turkish version. Moreover, the reliability analysis showed good internal consistency values for all the subscales and the total score. Finally, the HRI-24 total score was negatively and significantly correlated with BSSS-4 but positively and significantly correlated with SDQ, showing good convergent and divergent validity.
Conclusions: The HRI-24 scale is valid for screening Hikikomori risk in Turkish pre-adolescents and adolescents in both clinical and community samples. In addition, we provided first data about the Hikikomori profile of Turkish adolescents. Finally, this study also supported the cross-cultural validity of the Hikikomori construct and HRI-24.
Psychological Inflexibility in Spanish Adults: Characteristics of Emotional Eating and the Healthy Eating Index
Authors: Arbinaga F , Sierra Mar , Pedro Emilio
Published: June 2024

Objective: Eating disorders form a group of syndromes characterized by eating behaviors and psychological disturbances, accompanied by changes in weight and/or social alterations. These disturbances significantly influence social functioning and quality of life. The aim is to understand the relationship between psychological inflexibility, emotional eating, and the rate of healthy eating.
Methods: A total of 705 Spanish adults participated (65.2% women); the mean age was 27.21 years (SD = 10.67). The instruments used were Acceptance and Action Questionnaire, Eating and Appraisal Due to Emotions and Stress Questionnaire and the Healthy Eating Index for the Spanish population.
Results: The women showed significantly higher scores in psychological inflexibility than men (p < 0.001). No differences have been described in the Emotional Eating scale (p = 0.085) differences have been reported on the Self-efficacy in Emotion -and Stress-Related Eating subscale, where men do better at managing eating (p < 0.001). Females indicate better diet quality (p < 0.001). Those who show less psychological inflexibility obtain emotional eating scores indicative of less coping with emotions through food (p < 0.001). Groups formed according to psychological inflexibility do not differ in diet quality (p = 0.898).
Conclusion: The importance of psychological inflexibility is due to its role and strong association with a variety of problems related to eating behavior, but especially because it is a construct that can be intervened upon and modified.
РАСЧЕТ РЕКРЕАЦИОННОЙ НАГРУЗКИ И ЕМКОСТИ ПАРКА ИМЕНИ Т. САТЫЛГАНОВА
Authors: Абсатаров Р.Р. , Арынбаев Э.К. , Абылов Р.А.
Published: June 2024

В данной статье в качестве предмета исследования рассматривается рекреационная нагрузка и емкость парка имени Т. Сатылганова в городе Ош. Целью исследования был расчет рекреационных возможностей парка. Потому что сохранение парков города и оценка их экологического состояния решаются, прежде всего, путем определения максимально допустимого рекреационного потенциала парка. Рекреационная емкость парка определяется как сумма разрешенных рекреационных нагрузок и площадей отдельных участков на этой территории. В ходе исследования использовались методы полевых исследований и математические методы. Количество отдыхающих, одновременно посещающих парк, было принято за 10% населения, проживающего в доступной зоне города Ош. По результатам исследований рассчитана рекреационная нагрузка и емкость парка, а также оценена его функциональная зона путем анализа ее современного состояния. Определение рекреационной нагрузки городских парков имеет большое практическое значение в градостроительстве и управлении городской средой. Расчет этого параметра позволяет оценить спрос и загрузку парков горожанами, оптимизировать использование этих территорий, разработать меры по улучшению инфраструктуры и сервиса парков, а также принять решения о распределении ресурсов для удовлетворения потребности общества в зеленых зонах для отдыха и досуга.