bluuebunny/crossref_metadata_2025 huggingface dataset:
Can trainability constrain physical fitness adaptations to small-sided games and high-intensity interval training in young male basketball players? a prospective cohort study
Authors: Wei LiXin , Zheng YaFei
Published: December 2024

Introduction

Research on the effects of training programs involving small-sided games (SSG) versus high-intensity interval training (HIIT) has been increasing in recent years. However, there is limited understanding of how an individual's initial physical fitness level might influence the extent of adaptations achieved through these programs. This study aimed to compare the impacts of SSG and HIIT on male soccer players, while also considering the players' athleticism, categorized into lower and higher total athleticism score (TSA).

Methods

A prospective cohort study was conducted over a 6-week pre-season training period, involving 43 male soccer players from regional-level teams (average age 16.5 ± 0.7 years). Players were evaluated at the start and after the 6-week period. One team incorporated SSG as a core component of their aerobic-based training, while the other team used HIIT. Evaluations included a countermovement jump (CMJ) test, a 30-meter linear sprint test, and the 30–15 intermittent fitness test (30–15 IFT). TSA was calculated to assess each player's overall athleticism level (classifying them as fit and non-fit).

Results

Results revealed that non-fit players showed significantly greater CMJ improvements (mean difference: 3.0 cm; p < 0.005) and VIFT improvements (mean difference: 0.682 km/h; p = 0.002) in SSG compared to fit players. In the HIIT group, non-fit players also revealed greater improvements than fit players in CMJ (mean difference: 2.5 cm; p < 0.005) and peak speed in sprint (mean difference: 0.706 km/h; p = 0.002). No significant differences were found between groups regarding the observed improvements.

Discussion

In conclusion, this study suggests that the initial level of physical fitness significantly influences the magnitude of adaptations. Specifically, players with lower fitness levels appear to benefit more from training interventions. Improvements in CMJ and aerobic capacity in SSG seem to depend on players’ fitness levels, and a similar trend is observed in HIIT for CMJ and peak speed. Individualizing training programs is recommended, with a focus on providing greater or different stimuli to more well-prepared players to ensure their continued development.
Melatonin as a multifunctional modulator: emerging insights into its role in health, reproductive efficiency, and productive performance in livestock
Authors: Afzal Ali
Published: December 2024

Melatonin, a pleiotropic hormone plays a vital role in enhancing livestock performance not only by regulating circadian rhythms but also by exhibiting antioxidant, immunomodulatory, and metabolic regulatory effects that collectively improve resilience, fertility, and productivity. Melatonin’s synthesis is predominantly influenced by light exposure, with increased production in darkness; however, factors such as diet and health status further modulate its levels. By helping animals adapt to environmental stressors, melatonin boosts immune responses, mitigates chronic illnesses, and optimizes production efficiency. Its regulatory influence extends to the hypothalamic-pituitary-gonadal (HPG) axis, enhancing hormone secretion, synchronizing estrous cycles, and improving embryo viability. This results in improved reproductive outcomes through the protection of gametes, increased sperm motility, and enhanced oocyte quality, all of which benefit the fertilization process. Additionally, melatonin positively impacts productive performance, promoting muscle growth, development, and optimizing milk yield and composition through its interaction with metabolic and endocrine systems. As ongoing research continues to uncover its broader physiological effects, melatonin supplementation emerges as a promising approach to improving livestock welfare, productivity, and sustainability in modern animal husbandry.
Impact of an early educational protocol on the oral language of children born preterm exhibiting phonological fragility: a multicenter randomized clinical trial
Authors: Charollais Aude , Laudenbach Vincent , Stumpf Marie-Hélène , Delaporte Benoît , Datin-Dorriere Valérie , Debillon Thierry , De Barace Claire , Flechelles Olivier , Farmer Marie
Published: December 2024

We conducted a six-center, prospective, randomized, open-label trial to assess whether an early standardized educational protocol provided from 42 to 48 months of age improved the progression of oral language and phonological development in children born preterm. A total of 552 children with phonological fragility were included in this study. The children were randomized to receive the educational protocol (guided arm, n = 87) or not (non-guided arm, n = 78). In the guided arm, the oral language development used a short “say and do” type educational protocol designed to maintain visual attention and train the developmental phonology/lexicon/morphosyntax structural links. In contrast, a conservative approach was used in the non-guided arm. A total of 70 guided and 73 non-guided children completed the study. After 6 months, the educated children showed a non-significant increase in their phonology score (p = 0.37), while the variations in the scores of the expressive lexicon (secondary endpoints) were significantly improved (p = 0.0008). We conclude that the short, standardized stimulation of the sensorimotor aspects of language in children born very preterm increased the expressive lexicon. This protocol improved the language of the premature children, especially those with minimal motor skills, with more significant improvement in the phonological scores.

Clinical trial registration

clinicaltrials.gov, identifier NCT01426659
Evaluating walkability across age groups and flooring materials using IMU sensors
Authors: Jo Daehwi , Kim Hyunsoo
Published: December 2024

This study presents a novel approach to quantitatively assess the impact of flooring materials on walkability using Inertial Measurement Unit (IMU) sensors and Dynamic Time Warping (DTW) algorithm. Four common pavement materials (wood, asphalt, concrete block, and cement) were evaluated across five age groups (20–30, 30–40, 40–50, 50–60, and over 60 years) with 80 participants walking 1,200 m on each surface. IMU sensors attached to the lumbar region recorded acceleration and gyroscope data, which were then analyzed using DTW to quantify gait stability. Results showed significant differences in DTW values among materials, with wood exhibiting the lowest average DTW value (12.99 ± 3.05) indicating the most stable walking environment, while cement showed the highest (39.14 ± 9.74). In addition, age-related analysis revealed increasing DTW values with age across all materials, with the most pronounced effect in the older adult group. The methodology presented offers sensor-based approach for evaluating and optimizing pedestrian infrastructure in smart city development.
Evolution of scientific productivity in dentistry: tracking postgraduate publications at a Peruvian university
Authors: Rojas-Senador Cesar D. , Garcés-Elías María Claudia , León-Manco Roberto A.
Published: December 2024

Introduction

Scientific production indicators help universities quantitatively and qualitatively assess postgraduate students’ publications and contribute to the optimization of research processes. This study aimed to determine the frequency of publication in scientific journals of the documents submitted by postgraduate dentistry students to obtain a second professional specialty title and master's and doctoral degrees at a private Peruvian university over seven years.

Materials and methods

A cross-sectional study was conducted, considering the population and the records of documents submitted to obtain the second professional specialty title and the master's and doctoral degrees in dentistry at a private Peruvian university, published in its institutional repository from 2017 to 2023. The primary outcome was publication in scientific journals, and the covariates were the year of formal submission of the document, postgraduate level, modality of document preparation, area of dentistry specialty according to the American Dental Association, year of publication, international indexing, impact factor (IF), and quartile. A descriptive analysis was performed to obtain absolute and relative frequencies.

Results

Between 2017 and 2023, out of 322 documents submitted to receive the second professional specialty title and the master's and doctoral degrees published in the institutional repository, 72 were published in scientific journals. Of these, 81.94% (n = 59) were published in an internationally indexed scientific journal, with 13.56% (n = 8) published in a journal with an IF≥2 and 10.18% (n = 6) in a Q1 category journal.

Discussion

In low-income countries, the nexus between education and scientific output is multifaceted. While education serves as a critical catalyst, numerous challenges constrain the expansion of research. These nations contribute a mere 2% of global scientific production, despite confronting significant public health issues, underscoring a notable discrepancy between educational attainment and research productivity. The disparities in scientific output across universities in Latin America, Asia, and Europe are shaped by a confluence of cultural and economic determinants. In conclusion, 22.36% of the documents submitted to obtain the second professional specialty title and the master's and doctoral degrees by postgraduate dentistry students at a private Peruvian university over seven years were published in scientific journals.
Affects as affordances: disability and the genres of the actionable
Authors: Hiskes Andries
Published: December 2024

Prominent theorists such as Tobin Siebers, Ato Quayson, and Martha Stoddard Holmes have proposed that disability may not only elicit different affects, such as fear, admiration, or disgust, but have also envisioned different ways in which the relationship between affect and disability is becoming a central concern in considering how disability is ultimately lived through and experienced in social life. This paper supplements the conceptualization of the affect–disability relationship with the conceptual apparatuses of affordances and genre, to offer an account of the actionable. The actionable is proposed as a form of socio-cultural negotiation of the body and the environment out of which opportunities for action—or affordances— arise. Thomas Stoffregen has proposed affordances as being relational-emergent in nature, meaning that affordances refer to the possibilities for action within a particular constellation of elements, while simultaneously not being reducible to the properties of the individual elements. This paper proposes that affect, understood as the bodily capacities to act and be acted upon, may be understood as evoking affordances—opportunities to act or be acted upon. Additionally, the notions of impairment and disability suggest that capacities and the possibilities of action may vary across different bodies. I connect this to the work by Lauren Berlant on genre, who suggests that modes of responsivity to being affected are rooted in generic thinking. Genres act as structuring and historical forms that embed affect in appropriate modes of responsivity within genre conventions. Affordances are subsequently linked to what is deemed a fitting action within a genre. By invoking Berlant’s work, this paper proposes that the actionable opportunities afforded by bodies are preemptively inscribed in genre conventions, and that the concept of the actionable enables an analysis of which actions are deemed appropriate within genres. Because impaired and disabled bodies have a variety of capacities, these bodies may therefore also hold the capacity to disrupt generic expectations and therefore further emphasize the normativity of the presupposed appropriateness of actions.
Development and validation of animal variant classification guidelines to objectively evaluate genetic variant pathogenicity in domestic animals
Authors: Boeykens Fréderique , Abitbol Marie , Anderson Heidi , Casselman Iris , de Citres Caroline Dufaure , Hayward Jessica J. , Häggström Jens , Kittleson Mark D. , Lepri Elvio , Ljungvall Ingrid , Longeri Maria , Lyons Leslie A. , Ohlsson Åsa , Peelman Luc , Smets Pascale , Vezzosi Tommaso , van Steenbeek Frank G. , Broeckx Bart J.G.
Published: December 2024

Assessing the pathogenicity of a disease-associated genetic variant in animals accurately is vital, both on a population and individual scale. At the population level, breeding decisions based on invalid DNA tests can lead to the incorrect inclusion or exclusion of animals and compromise the long-term health of a population, and at the level of the individual animal, lead to incorrect treatment and even life-ending decisions. Criteria to determine pathogenicity are not standardized, i.e., no guidelines for animal variants are available. Here, we aimed to develop and validate guidelines to be used by the community for Mendelian disorders in domestic animals to classify variants in categories based on standardized criteria. These so-called animal variant classification guidelines (AVCG) were based on those developed for humans by The American College of Medical Genetics and Genomics (ACMG). In a direct comparison, 83% of the pathogenic variants were correctly classified with ACMG, while this increased to 92% with AVCG. We described methods to develop datasets for benchmarking the criteria and identified the most optimal in silico variant effect predictor tools. As the reproducibility was high, we classified 72 known disease-associated variants in cats and 40 other disease-associated variants in eight additional species.
Novel Aspects of Immunogenetics and Post-Transplant Events in Kidney Transplantation
Authors: Helanterä Ilkka , Markkinen Salla , Partanen Jukka , Hyvärinen Kati
Published: December 2024

HLA typing and matching have been crucial in kidney transplantation, but methods for assessing tissue histocompatibility have advanced significantly. While serological-level HLA typing remains common, it captures only a small fraction of true HLA variation, and molecular matching is already replacing traditional HLA matching. Recent studies have expanded our understanding of genetic tissue compatibility beyond HLA loci. Candidate gene analyses and genome-wide association studies (GWAS) have identified genetic factors linked to post-transplant complications, though replication of these findings is challenging. An alternative approach involves genome-wide matching of genes or genetic variations. This method has shown promise in hematopoietic stem cell and kidney transplantation. For instance, homozygous gene deletions in LIMS1 or complement factor H (CFH) genes have been associated with acute rejection risk. This may be due to alloimmune responses against proteins absent in the patient but present in the graft, or due to the missing protein’s function. Genetic studies in clinical medicine face challenges due to the interplay of genetic and environmental factors, necessitating large datasets for meaningful associations. International collaboration and large consortia, like iGeneTRAin, are essential for validating findings and advancing the field. This review highlights recent advancements in immunogenetics and tissue histocompatibility, emphasizing future research directions.
An In Vitro Evaluation of Robin’s Pincushion Extract as a Novel Bioactive-Based Antistaphylococcal Agent—Comparison to Rosehip and Black Rosehip
Authors: Šovljanski Olja , Aćimović Milica , Cvanić Teodora , Travičić Vanja , Popović Aleksandra , Vulić Jelena , Ćetković Gordana , Ranitović Aleksandra , Tomić Ana
Published: December 2024

Introduction: This study explores the bioactive properties of extracts obtained from Robin’s pincushion (Diplolepis rosae) collected in Sokobanja, Serbia. Results: Comprehensive in vitro assessments reveal high concentrations of total phenolics (186.37 mg GAE/g), along with significant levels of carotenoids (44.10 μg β-car/g). Robin’s pincushion exhibited superior antioxidant capacities across DPPH, ABTS, and reducing power assays, significantly outperforming comparable extracts from rosehip (Rosa canina) and black rosehip (Rosa spinosissima) in these activities. Additionally, high inhibitory effects were observed in antimicrobial assays, with the extract demonstrating minimal inhibitory concentrations (MIC) as low as 1.56 mg/mL against the Staphylococcus species. Notably, the extract achieved full bactericidal effect within 24 h in time-kill kinetic studies which additionally highlight its potent antistaphylococcal potential. Materials and methods: Analyzing their phytochemical profiles and evaluating their potential as antioxidant, anti-inflammatory, antihyperglycemic, and antimicrobial agents, wide-ranging evaluation of bioactivity of Robin’s pincushion was conducted. Conclusions: These findings highlight Robin’s pincushion as a promising natural source of bioactive compounds with potential applications in traditional and modern medicine for managing oxidative stress, inflammation, hyperglycemia, and microbial infections.
Application of Pathomic Features for Differentiating Dysplastic Cells in Patients with Myelodysplastic Syndrome
Authors: Hong Youngtaek , Jeong Seri , Park Min-Jeong , Song Wonkeun , Lee Nuri
Published: December 2024

Myelodysplastic syndromes (MDSs) are a group of hematologic neoplasms accompanied by dysplasia of bone marrow (BM) hematopoietic cells with cytopenia. Recently, digitalized pathology and pathomics using computerized feature analysis have been actively researched for classifying and predicting prognosis in various tumors of hematopoietic tissues. This study analyzed the pathomic features of hematopoietic cells in BM aspiration smears of patients with MDS according to each hematopoietic cell lineage and dysplasia. We included 24 patients with an MDS and 21 with normal BM. The 12,360 hematopoietic cells utilized were to be classified into seven types: normal erythrocytes, normal granulocytes, normal megakaryocytes, dysplastic erythrocytes, dysplastic granulocytes, dysplastic megakaryocytes, and others. Four hundred seventy-six pathomic features quantifying cell intensity, shape, and texture were extracted from each segmented cell. After comparing the combination of feature selection and machine learning classifier methods using 5-fold cross-validation area under the receiver operating characteristic curve (AUROC), the quadratic discriminant analysis (QDA) with gradient boosting decision tree (AUROC = 0.63) and QDA with eXtreme gradient boosting (XGB) (AUROC = 0.64) showed a high AUROC combination. Through a feature selection process, 30 characteristics were further analyzed. Dysplastic erythrocytes and granulocytes showed lower median values on heatmap analysis compared to that of normal erythrocytes and granulocytes. The data suggest that pathomic features could be applied to cell differentiation in hematologic malignancies. It could be used as a new biomarker with an auxiliary role for more accurate diagnosis. Further studies including prediction survival and prognosis with larger cohort of patients are needed.
Multimodality Fusion Aspects of Medical Diagnosis: A Comprehensive Review
Authors: Kumar Sachin , Rani Sita , Sharma Shivani , Min Hong
Published: December 2024

Utilizing information from multiple sources is a preferred and more precise method for medical experts to confirm a diagnosis. Each source provides critical information about the disease that might otherwise be absent in other modalities. Combining information from various medical sources boosts confidence in the diagnosis process, enabling the creation of an effective treatment plan for the patient. The scarcity of medical experts to diagnose diseases motivates the development of automatic diagnoses relying on multimodal data. With the progress in artificial intelligence technology, automated diagnosis using multimodal fusion techniques is now possible. Nevertheless, the concept of multimodal medical diagnosis is still new and requires an understanding of the diverse aspects of multimodal data and its related challenges. This review article examines the various aspects of multimodal medical diagnosis to equip readers, academicians, and researchers with necessary knowledge to advance multimodal medical research. The chosen articles in the study underwent thorough screening from reputable journals and publishers to offer high-quality content to readers, who can then apply the knowledge to produce quality research. Besides, the need for multimodal information and the associated challenges are discussed with solutions. Additionally, ethical issues of using artificial intelligence in medical diagnosis is also discussed.
Effectiveness of Bobath Therapy vs. Conventional Medical Gymnastics in Psycho-Social and Cognitive Status Improvement in Children with Mild Neurodevelopmental Delay: A Randomized Double-Blinded Prospective Cohort Study
Authors: Djukić Koroljević Zrinka , Bulić Luka , Brenner Eva , Bračić Matea , Brlek Petar , Primorac Dragan
Published: December 2024

Background/Objectives: The main objective of this research was to compare the Bobath concept and conventional medical gymnastics in psycho-social and cognitive habilitation of infants with mild neurodevelopmental delay, and determine whether there is a difference in their effectiveness. Methods: The study included 100 children up to 3 months of age who were diagnosed with a mild neuromotor disorder based on clinical examination, the Münich Functional Developmental Diagnostic Test for the first year of life, and the Ages and Stages questionnaire. The respondents were randomized into two groups, habilitated according to the Bobath concept or conventional medical gymnastics. The observed parameters were problem-solving skills, communication skills, and the infants’ psycho-social status. Results: The Ages and Stages questionnaire revealed no significant differences between the two concepts. The Munich Diagnostic Test revealed different starting values in speech and socialization delay, but the treatment outcomes showed significant improvement in both cohorts. There were also no significant differences in the guardians’ opinions on therapeutic effectiveness. Conclusions: This study demonstrated that there is no difference in effectiveness between the two tested habilitation programs in mild neurodevelopmental delay treatment in infants after six months of therapy, laying the foundation for a professional consensus.
Level of Agreement Between Plaque Detection with Clinical Assessment and Assessment on Intraoral Scanner
Authors: Gkavela Grigoria , Nørrisgaard Pia Elisabeth , Rahiotis Christos
Published: December 2024

Background/Objectives: The aim was to evaluate the agreement between plaque detection with an intraoral scanner system (IOS) and a conventional clinical method and to evaluate the inter-rater reliability for scoring 3D models with and without a disclosing agent. Methods: A total of 14 participants were recruited from the Department of Operative Dentistry, School of Dentistry, National and Kapodistrian University of Athens. Participants eligible for inclusion were adults with good general health and a minimum of 20 teeth. Participants were clinically examined with plaque assessment according to the modified Quigley–Hein plaque index before and after using a disclosing agent (GC-Tri Plaque ID-Gel, GC, Europe N.V). Before and after the application of the disclosing agent, all study participants were scanned using the IOS (TRIOS5, 3Shape TRIOS A/S). The clinical examiner and three additional examiners blinded to the clinical examination assessed plaque status on the acquired 3D models with and without disclosing agent using the same index to evaluate the inter-rater agreement. Intraclass coefficient correlation, one sample t-test, and Cronbach’s α for inter-rater reliability were calculated. Results: All methods showed moderate to strong correlations (Spearman’s rho ranging from 0.527 to 0.618), and Cronbach’s α ranged from 0.551 to 0.766. Conclusions: The level of agreement between conventional clinical registration and registration from 3D models was acceptable overall.
Fostering Organizational Sustainability Through Employee Collaboration: An Integrative Approach to Environmental, Social, and Economic Dimensions
Authors: Ispiryan Audrone , Pakeltiene Rasa , Ispiryan Olympia , Giedraitis Algirdas
Published: December 2024

This study aims to develop a multifaceted conceptual basis for employee collaboration with regard to promoting organizational sustainability, which encompasses environmental, social, and economic dimensions. Employing a mixed-methods framework, the study integrates a thorough literature review with a qualitative content analysis. A distinctive feature of this investigation is its emphasis on incorporating collaborative methodologies into sustainability strategies across various organizational frameworks, illustrating how collaboration can be refined through adaptive leadership, interdisciplinary teams, and digital technologies. The results indicate that organizations characterized by a robust collaborative culture demonstrate greater success in fostering sustainable innovations, minimizing environmental repercussions, and enhancing employee engagement. Furthermore, the study introduces a novel model that correlates collaboration with operational sustainability, taking into account diverse levels of resource sharing, leadership engagement, and employee empowerment. By focusing on actionable strategies, this research provides novel insights into how adaptive leadership, digital tools, and shared responsibility can transform collaboration into a driver of sustainability. This research enriches the existing body of literature by presenting an evidence-based framework for cultivating sustainable organizational cultures and provides valuable insights for prospective research on harnessing collaboration to attain long-term sustainability goals.
Mixed Strains of Bacillus velezensis PBS-17, Lactiplantibacillus plantarum J-135, and Saccharomyces cerevisiae DAE-4 Increase the Storage Capacity of Fermented Feed and Silage
Authors: Park Eun-Jae , Kim Moon Joo , Lee Bori , Jang Hyun-Jae , Lee Seung Woong
Published: December 2024

In this study, we investigated whether three microbial strains, Lactiplantibacillus plantarum J-135, Saccharomyces cerevisiae DAE-4, and Bacillus velezensis PBS-17, could be used to reduce mold growth and spoilage during the production of fermented feed. These microorganisms were isolated and characterized via an evaluation of their antibacterial activity, enzymatic activity, bile acid resistance, and acid tolerance. L. plantarum J-135 and S. cerevisiae DAE-4 demonstrated excellent acid tolerance and bile acid resistance, and L. plantarum J-135 exhibited antibacterial activity against Salmonella species. B. velezensis PBS-17 showed the greatest protease, cellulase, α-amylase, and phytase enzymatic activities, and displayed antibacterial activity against Fusarium solani, Aspergillus flavus, Penicillium sp., and Fusarium oxysporum. The three isolated strains were diluted to the same concentration (1:1:1) to create a culture solution, which was added to a standard feed (experimental group) to prepare fermented feed. This was compared with feed treated with a commercially available single probiotic preparation (control group 1) or a mixed microbial preparation that was composed of multiple strains, including B. subtilis. The feed treated with the single probiotic preparation spoiled after 21 days due to insufficient lactic acid bacteria growth, whereas the feed treated with the mixed microbial preparation exhibited mold growth after 14 days. The bacteria and fungi that cause spoilage during fermented feed production were effectively controlled in feed treated with L. plantarum J-135, S. cerevisiae DAE-4, and B. velezensis PBS-17. Therefore, the mixture of these three microbial strains may reduce the risk of spoilage during fermented silage and feed processing, thereby improving storage properties and stability.
Optimization of Ultraviolet-B Treatment for Enrichment of Total Flavonoids in Buckwheat Sprouts Using Response Surface Methodology and Study on Its Metabolic Mechanism
Authors: Xue Jiyuan , Hu Meixia , Yang Jia , Fang Weiming , Yin Yongqi
Published: December 2024

Buckwheat possesses significant nutritional content and contains different bioactive compounds, such as total flavonoids, which enhance its appeal to consumers. This study employed single-factor experiments and the response surface methodology to identify the optimal germination conditions for enhancing the total flavonoid content in buckwheat sprouts through ultraviolet-B treatment. The research showed that buckwheat sprouts germinated for 3 days at a temperature of 28.7 °C while being exposed to ultraviolet-B radiation at an intensity of 30.0 μmol·m−2·s−1 for 7.6 h per day during the germination period resulted in the highest total flavonoid content of 1872.84 μg/g fresh weight. Under these specified conditions, ultraviolet-B treatment significantly elevated the activity and gene expression levels of enzymes related to the phenylpropanoid metabolic pathway, including phenylalanine ammonia-lyase, cinnamic acid 4-hydroxylase, 4-coumarate coenzyme A ligase, and chalcone isomerase. Ultraviolet-B treatment caused oxidative damage to buckwheat sprouts and inhibited their growth, but ultraviolet-B treatment also enhanced the activity of key enzymes in the antioxidant system, such as catalase, peroxidase, superoxide dismutase, and ascorbate peroxidase. This research provided a technical reference and theoretical support for enhancing the isoflavone content in buckwheat sprouts through ultraviolet-B treatment.
Heat Treatment of Hazelnut Allergens Monitored by Polyclonal Sera and Epitope Fingerprinting
Authors: Kern Karolin , Santa-Ardharnpreecha Suttinee , Delaroque Nicolas , Dölle-Bierke Sabine , Treudler Regina , Ehrentreich-Förster Eva , Rothkopf Isabell , Worm Margitta , Szardenings Michael
Published: December 2024

Hazelnuts are frequently involved in IgE-mediated reactions and are the main cause of nut allergies in Europe. Most food products are processed before human consumption. Food processing can modify the structure, properties, and function of proteins, and as a result, the IgE-binding capacity of allergens can be affected. In this study, we aimed to investigate epitope changes caused by the roasting of hazelnuts using epitope fingerprinting. Rabbit sera were raised against hazelnut proteins, and their epitopes were characterized. Immunoassays using specific polyclonal antibodies from rabbits targeting the main allergens in hazelnuts revealed marked reductions in the levels of Cor a 1 (PR-10), Cor a 11 (7S globulin), and Cor a 14 (2S albumin). However, rabbit antibodies can recognize different epitopes. Using antibodies that are different and characterized could help establish reliable methods for estimating the effects of treatments on the allergenicity of foods. In this work, we provide the first practical application that could lead to sets of peptide epitopes to compare and standardize immune diagnostics, even for complex protein preparations.
Potential Unlocking of Biological Activity of Caffeic Acid by Incorporation into Hydrophilic Gels
Authors: Jokubaite Monika , Ramanauskiene Kristina
Published: December 2024

Caffeic acid, a phenolic compound with antioxidant and antimicrobial properties, shows promise in the dermatological field. The research aimed to incorporate caffeic acid into hydrophilic gels based on poloxamer 407, carbomer 980, and their mixture in order to enhance its biological activity. Different gel formulations were prepared using different concentrations of these polymers to optimize caffeic acid release characteristics. The results showed that increasing the concentration of polymeric materials increased the viscosity and slowed down the release of caffeic acid. The antioxidant and antimicrobial activities of the gels were assessed. The results confirmed the potential of hydrophilic gels as delivery systems for caffeic acid, with formulations showing antimicrobial activity against Gram-positive Staphylococcus aureus bacteria and antifungal activity against Candida albicans fungus. This study provides a perception of the development of new semi-solid caffeic acid-based formulations for therapeutic and cosmetic applications.
Effect of Reformer Spring Resistance Modifications on Core Muscle Activity During Basic Core Muscle Exercises
Authors: Kim Hee-Jeong , Sung Jung-Ha , Ryu Jae-Kyun , Jung Hyun-Chul , Wang Junsig
Published: December 2024

Background: Core muscles serve as a central group within the functional kinetic chain, stabilizing the spine during movement. The Reformer is one of the most popular and primary pieces used in Pilates core exercises, requiring effective control of core muscles. The purpose of this study was to investigate the effect of Reformer spring resistance on core muscle activity. Method: 18 healthy adult females (age: 29.83 ± 4.22 years, body height: 164.98 ± 4.14 cm, body mass: 53.67 ± 5.32 kg) participated in this study. Surface electromyography was recorded from six muscles: rectus abdominis, internal oblique, erector spinae, multifidus, rectus femoris, and biceps femoris during core exercises. Participants performed three core exercises (hip roll, knee-off, and elephant) under three different Reformer spring conditions (fixed platform, platform connected to springs with moderate resistance, platform connected to springs with low resistance). Results: During the hip roll exercise, mean muscle activity of the rectus abdominis, erector spinae, multifidus, and biceps femoris was significantly increased on the low-resistance spring platform compared to the moderate-resistance platform and fixed platform conditions (p < 0.001). During the knee-off exercise, mean muscle activity of the rectus abdominis, internal oblique, erector spinae, and multifidus significantly increased on the low-resistance platform compared to the fixed platform (p < 0.001). Furthermore, during the elephant exercise, mean muscle activity of the rectus abdominis, internal oblique, and rectus femoris significantly increased on the low-resistance spring platform compared to the fixed platform (p < 0.001). Conclusions: These findings suggest the unstable platform caused by the Reformer spring modification impacts core muscle activity during basic core exercises. Therefore, when designing core exercise programs using the Reformer, platform instability should be considered a key factor for rehabilitation and core stability.
Farmhouses in the Mid-Adriatic: From Architectural Artifacts to Devices for the Landscape Development
Authors: Cipolletti Sara
Published: December 2024

Rural settlement in Central Italy represents one of the most original heritages for understanding the link between architectural principles and the environmental, economic, and social aspects of the cultivated land. The scattered farmhouses are the basis of a particular land management strategy, the Mezzadria (sharecropping), a contract between a landowner and a farmer. The structure of the architecture is always the same, with slight variations, and is characterized by an external staircase that is the prevailing distinctive element. However, the isolated buildings developed a complex system of relations in the territory, a cultural landscape process made up of physical and visual connections. This paper investigates the rural architecture of Central Italy, particularly in the mid-Adriatic area of southern Marche, renewing the knowledge of this peculiar heritage. The exploratory method considers different scales and is based both on the interpretation of hilly geography and on architectonic comparison between artifacts. Ruins in situ visual exploration, valuation of historical maps, and transcription of signs elaborated in drawings and photographs allow us for better identification of the open space relations and building characters. It is concluded that farmhouses are not only architectural objects with ‘honest functional logic’ but real devices for the creation of the hillside landscape, so they need broad investigations that start from solid scientific references to direct future trajectories.
Hydroponic Fiber Mats Altered Shoot Growth and Mineral Nutrient Composition of Five Herbal Microgreens
Authors: Li Tongyin , Arthur Jacob D. , Bi Guihong , White Shecoya
Published: December 2024

Microgreens are nutrient-dense foods rich in mineral nutrients and health-benefiting phytochemicals. They are a popular specialty crop with a rapidly increasing industry in the United States (U.S.A.) and worldwide. However, there is a lack of research-based recommendations regarding the feasibility of using hydroponic fiber mats in the production of herbal microgreens and their effects on yield, quality, and nutritional composition. This study assessed shoot development, yield, visual quality, and mineral composition of five herbal microgreen species, including basil, chives, dill, leek, and parsley when grown with four types of hydroponic fiber mats (BioStrate, hemp, jute, and MicroMat) and affected by a single post-emergent fertigation in two experiments. The five microgreens varied in yield, quality, mineral nutrient composition, and their response to substrate type. Chives microgreens produced the highest fresh and dry shoot weights among species when grown with BioStrate, jute, and MicroMat in both experiments. The four substrate types resulted in similar fresh and dry shoot weights in leek and parsley microgreens in both experiments. However, BioStrate and MicroMat increased fresh and dry shoot weights in chives in December compared with hemp or jute mats. Jute resulted in higher fresh and dry shoot weights in basil in both experiments compared with MicroMat. The fiber mats altered mineral nutrient concentrations in tested microgreen species. Hemp mats increased potassium concentrations in basil and dill, while jute mats produced the highest Fe concentrations in the two species and the highest Mn concentration in basil in both experiments. A single post-emergent fertigation increased shoot height and increased concentrations of nitrogen, phosphorus, potassium, sulfur, iron, zinc, manganese, and boron in one or both experiments.
Emotional Distress and Cardiovascular Health in Young Adults with Type 1 Diabetes
Authors: Armentrout Bethany L. , Ahmed Bootan H. , Waraphok Sineenat , Huynh Johnathan , Griggs Stephanie
Published: December 2024

Type 1 diabetes (T1D) is a complex chronic condition that places young adults aged 18–31 years at high risk for general and diabetes-related distress and poor cardiovascular health. Both general and diabetes distress are linked to higher A1C, a known risk factor for cardiovascular disease (CVD). The purpose of this cross-sectional quantitative descriptive study was to examine the associations between distress symptoms (general and diabetes) and cardiovascular health while considering covariates in young adults ages 18–31 years with T1D. One-hundred and sixty-five young adults with T1D, recruited from specialty clinics through two major health systems and online platforms, completed a demographic and clinical survey along with the 8-item PROMIS Emotional Distress Scale and 17-item Diabetes Distress Scale. Higher diabetes distress and higher general emotional distress were associated with lower cardiovascular health scores. Associations remained statistically significant after adjusting for age, T1D duration, sex at birth, race, and continuous subcutaneous insulin infusion. In young adults with type 1 diabetes, addressing both diabetes and general emotional distress may be important to improve cardiovascular health. However, longitudinal and experimental studies are needed to clarify underlying mechanisms and evaluate the effectiveness of interventions like cognitive behavioral therapy.
Design Optimization of a Marine Propeller Shaft for Enhanced Fatigue Life: An Integrated Computational Approach
Authors: Tuninetti Víctor , Martínez Diego , Narayan Sunny , Menacer Brahim , Oñate Angelo
Published: December 2024

This study investigates the design and potential failure modes of a marine propeller shaft using computational and analytical methods. The aim is to assess the structural integrity of the existing design and propose modifications for improved reliability and service life. Analytical calculations based on classification society rules determined acceptable shaft diameter ranges, considering torsional shear stress limits for SAE 1030 steel. A Campbell diagram analysis identified potential resonance issues at propeller blade excitation frequencies, leading to a recommended operating speed reduction for a safety margin. Support spacing was determined using both the Ship Vibration Design Guide and an empirical method, with the former yielding more conservative results. Finite element analysis, focusing on the keyway area, revealed stress concentrations approaching the material’s ultimate strength. A mesh sensitivity analysis ensured accurate stress predictions. A round-ended rectangular key geometry modification showed a significant stress reduction. Fatigue life analysis using the Goodman equation, incorporating various factors, predicted infinite life under different loading conditions, but varying safety factors highlighted the impact of these conditions. The FEA revealed that the original keyway design led to stress concentrations exceeding allowable limits, correlating with potential shaft failure. The proposed round-ended rectangular key geometry significantly reduced stress, mitigating the risk of fatigue crack initiation. This research contributes to the development of more reliable marine propulsion systems by demonstrating the efficacy of integrating analytical methods, finite element simulations, and fatigue life predictions in the design process.
Atypical Linear Tectonic Block of the Intraplate Deformation Zone in the Central Indian Ocean Basin
Authors: Yutsis Vsevolod V. , Levchenko Oleg V. , Tevelev Alexander V. , Marinova Yulia G. , Veklich Ilia A. , Del Razo Gonzalez Abraham
Published: December 2024

The Central Indian Ocean Basin (CIOB) is distinguished by unusually high tectonic activity, setting it apart from all other passive oceanic basins. Within the interior of the Indo-Australian lithospheric plate lies a unique area of intraplate deformation. This region is characterized by the highest recorded intraplate oceanic seismicity, with earthquake magnitudes reaching up to M = 8, abnormally high heat flow—measured to be two to four times higher than background levels for the ancient oceanic lithosphere of the Cretaceous age—and, most notably, intense folding and faulting of sediments and the basement, which are typically associated only with boundary zones of lithospheric plates. This anomalously tectonically active intraplate area was studied during regular research cruises in the 1970s–1980s, after which new conclusions were mainly drawn from satellite data modeling. Substantially new geophysical data were obtained in 2017 after a long gap. Bathymetric surveys using multibeam echosounders during the 42nd cruise of the R/V (Research Vessel) Akademik Boris Petrov and the SO258/2 cruise of the R/V Sonne provided full coverage of a large portion of the intraplate deformation area in the CIOB. This confirmed the mosaic-block structure of the intraplate deformation zone in the Central Indian Ocean Basin, consisting of numerous isometrically deformed tectonic blocks. A linear block at 0.2–0.6° S, which has a branch-like shape in plain view, is morphologically distinct from these blocks. It represents a system of structural elements of different scales (folds, flexures, ruptures), which constitute a structural paragenesis formed in the mechanical environment of a dextral transpressive tectonic setting.
Analysis of Characteristics and Main Controlling Factors of Shallow Geological Hazards in the Zhongsha Islands Region of the South China Sea
Authors: Wang Rui , Wang Yang , Ye Qunfang , Zhang Yunzhong
Published: December 2024

This study utilized single-channel seismic, multi-channel seismic, and multibeam bathymetric data to examine the distribution and geomorphological background of geological hazards in the Zhongsha Islands region of the South China Sea. We elucidate the regional geological structure and its evolution while focusing on the types and characteristics of submarine hazards since the Quaternary Period. By integrating geomorphological, tectonic, and sedimentary factors, we analyzed the primary drivers of shallow geological hazards in the region. Our findings reveal that seabed topography, tectonic activity, and sedimentary processes critically influence hazard formation, particularly in geomorphic units prone to disasters, such as submarine slopes and canyons. Igneous rocks in the region display medium-acid to medium-basic compositions, with notable developmental stages during the Himalayan and Yanshan periods. From the Paleogene to the Middle Miocene, tectonic activity intensified, significantly thinning the lithosphere. By the Middle Miocene, the crust stabilized into its present configuration, marking the formation of key tectonic units in the region. Multiple phases of sedimentary evolution, influenced by the Cenozoic tectonic movements, further contribute to the region’s susceptibility to geological hazards.
Mapping Agricultural Greenhouse Gas Emissions via Multi-National Supply Chains: Evidence from Asia and the Pacific Countries
Authors: Song Zhouying , Guan Jing , Han Mengyao
Published: December 2024

The rapid increase in global agricultural trade has drawn increasing attention to greenhouse gas (GHG) emissions stemming from agricultural activities. Through the application of multi-regional input–output modeling and complex network analysis, this study links embodied GHG emissions with the agricultural trade network especially focusing on Asia and the Pacific countries. The results showed a consistent upward trend in the total amount of direct agricultural GHG emissions associated with both production and consumption activities. However, the embodied agricultural GHG emissions exhibited a larger scale and higher growth rate. Among them, the pathways from Brazil to China and the United States to China are the largest net emission flows within this area. Regional clusters were observed in North America, Western Europe, and Southeast Asia, and their agricultural GHG patterns showed evolutionary characteristics. By depicting embodied agricultural GHG emissions and identifying GHG emission transfer patterns, this study aimed to promote agricultural GHG emission reduction strategies, which attempt to promote sustainable development by encouraging the low-carbon agricultural industry.
Effect of Oil Film Radial Clearances on Dynamic Characteristics of Variable Speed Rotor with Non-Concentric SFD
Authors: Nie Weijian , Yang Xiaoguang , Tang Guang , Zhang Qicheng , Wang Ge
Published: December 2024

Variable-speed aircraft engines require the power turbine rotor to operate stably within a wide range of output speeds, posing a challenge for rotor vibration reduction design. Non-concentric squeeze film dampers (NCSFDs) have been widely used in rotor vibration reduction design due to their simple structure. However, comprehensive research on the matching and applicability of NCSFDs under varying operating speeds is lacking. Therefore, this paper investigates the influence of oil film radial clearances on the dynamic characteristics of a variable-speed rotor system with an NCSFD, examining its suitability across variable speeds. This study introduces the principle of equivalent rotor dynamics similarity design, demonstrating good consistency between simulated and real rotor dynamic characteristics, with a radial clearance of 0.10 mm being deemed optimal. The vibration response variation in the rotor at a fixed speed within the range of 0.51 n to 1.0 n does not exceed 4 μm, and the vibration acceleration variation does not exceed 0.04 g, indicating a wide, stable operating speed range. This study can be helpful for the engineering design and vibration reduction design of variable-speed rotors in aircraft engines.