bluuebunny/crossref_metadata_2025 huggingface dataset:
Resolution of the National interdisciplinary expert council «The use of high-dose vitamin D for the prevention and treatment of vitamin D deficiency, including in comorbid patients, in the use of endocrinologists, rheumatologists, gerontologists and internists/GPS»
Authors: Belaya Zh. E. , Pigarova E. A. , Rozhinskaya L. Ya. , Arutyunov G. P. , Gilyarevsky S. R. , Dudinskaya E. N. , Markina N. V. , Melnichenko G. A. , Petunina N. A. , Skripnikova I. A. , Tkacheva O. N. , Shestakova M. V.
Published: August 2024

We present a consensus on high dose cholecalciferol (Devilam 5000 IU and 50000IU) prescription in clinical settings. There was a expert committee meeting to reach a consensus on the recommendations for endorcrinologists, primary care physicians and primary care specialists to prevent and treat vitamin D deficiency in various groups of patients. The expert committee reached a consensus on prescribing prophylactic doses of vitamin D in daily, weekly and monthly regimes to prevent vitamin D deficiency without vitamin D measurements. A single dose of cholecalciferol 50 000 IU should be prescribed to patients with low traumatic fractures and/or requiring antiresorptive treatment for osteoporosis when vitamin D measurement is not available. Treatment doses (50 000 IU per week) of vitamin D should be reserved for patients with established vitamin D deficiency (< 30ng/ml). Considering the prevalence of vitamin D deficiency in Russia, the expert committee suggested that all people require prophylactic doses of vitamin D from November to April, whereas the elderly (65+) benefit from whole year vitamin D supplementation. There is a group of people with vitamin D metabolism abnormalities associated with hypercalcemia (genetic or granulomatosis disorders) who should avoid vitamin D. On the other hand, patients with obesity, malabsorption and osteomalacia require higher doses of vitamin D for longer periods of time. High-dose vitamin D formulation in matrix form (50,000 IU, 5,000 IU) is a high-dose vitamin D preparation within the framework of the registered instructions for the prevention (in intermittent dosing mostly) and treatment of vitamin D deficiency/insufficiency. Taking into account the rapid achievement of a therapeutic effect, good tolerability, safety of the drug and the convenience of intermittent administration to achieve greater patient compliance with the treatment, the expert committee has come to the conclusion that high-dose vitamin D formulation in matrix form should be recommended in different group of people to be given according to this consensus.
Spinal column injuries: from the very beginning
Authors: Mikhaylovskiy M. V.
Published: August 2024

The history of medicine is interesting and instructive. In each of the many branches of medical science, the specificity of pathology determines diagnosis and treatment. These processes inevitably continue in time and space in accordance with the conditions existingin a given place and in a given period of time. Spine injury is one of the most striking examples of the longevity and duration of this process.Humanity relatively recently discovered what diabetes is and how it should be treated, but this branch of medicine also has its own history, although not a very long one. Spinal injuries have accompanied man and his predecessors almost always, disrupting the usual rhythmof life, and therefore they have been required to be treated since time immemorial. A true professional is always interested in the history of his specialty. Spine surgeons are no exception. What we managed to collect bit by bit, of course, is not everything, but it is impossible to grasp the immense, and it is necessary to know the past in order to better understand the present and the future.
Los incumplimientos graves del empresario como causa genérica de resolución indemnizada del contrato de trabajo
Authors: Nieves Nieto Nuria de
Published: August 2024

Los incumplimientos graves del empresario constituyen una causa justa que permite al trabajador fundamentar la solicitud de extinción indemnizada del contrato de trabajo. Esta escueta formulación plantea muchos interrogantes ¿a qué incumplimientos se refiere? ¿cuándo estos pueden considerarse suficientemente graves? ¿es necesario que el empresario sea culpable? ¿debe el trabajador forzosamente requerir la resolución o puede poner fin, por sí mismo, al contrato?... La interpretación de esta cláusula resolutoria viene dando lugar, desde hace más de cuatro décadas, a innumerables esfuerzos doctrinales y judiciales. Para dar respuesta a esas y otras cuestiones se ha de acudir no solo a lo dispuesto por el legislador en el artículo 50.1.c) del Estatuto de los Trabajadores sino también, necesariamente, a lo señalado por la jurisprudencia. La confluencia de ambas fuentes de conocimiento jurídico ha permitido proponer ciertos elementos estructurales integradores de la vía genérica de resolución causal indemnizada. Sin embargo, la alta indeterminación del enunciado normativo aconseja revisar estas notas a fin de constatar la vigencia y el alcance actuales de cada una de ellas. Ciertamente, la fórmula resolutiva abierta utilizada por la ley tiene vocación de acoger una variada casuística que no puede abordarse completamente, pero sí es posible reconducir, sistemáticamente, a dos grandes esferas: la primera incluye los supuestos de incumplimientos empresariales conexos con las causas expresamente contempladas en el artículo 50.1 del ET pero no subsumibles en ellas, y la segunda comprende aquellos que han ido surgiendo de la aplicación judicial, algunos ya consolidados y otros de reciente incorporación.
Virtual Screening of Syzygium cumini (L.) Skeels Flavonoid Compounds as SARS-CoV-2 Main Protease Therapy Candidates
Authors: Hidayah Himyatul , Ruswanto Ruswanto , Lestari Desri , Amal Surya , Gunarti Neni Sri
Published: August 2024

In December 2019, the first COVID-19 cases were in Wuhan, China. This case is a global concern and a threat to public health. Based on previous research using molecular docking methods, it was found that flavonoids exhibit strong inhibitory activity in SARS-CoV-2 main proteases. The study aims to determine the flavonoid compound Syzygium cumini (L.) Skeels can interact with the SARS-CoV-2 main protease receptor and can be used as a candidate for COVID-19 therapy with virtual screening. Myricetin 4”-O-acetyl-2-O-gallate has the lowest Gibbs free energy (ΔG) of -9.82 kcal/mol. The molecular dynamics of the best compound, Myrcetin 4-O-acetyl-2-O-gallate, RMSD, and RSMF values are quite stable. As a result of pharmacokinetic prediction and toxicity, the best compounds have a relatively good pharmacokinetic profile and are non-toxic. Thus, it can be concluded that the compound Myricetin 4”-O-acetyl-2-o-gallate in the Syzygium cumini (L.) Skeels is predicted to interact with the SARS-CoV-2 main protease receptor (7C6S) as a potential drug candidate for COVID-19 therapy.
Comparative study of plant diversity around water towers in hyper-arid areas (Adrar, Algeria)
Authors: Souddi Mohammed , Bouallala M’hammed
Published: August 2024

Water is a vital compound that determines the life of all organisms, but is often deficient, especially in hyper-arid areas. The rapid development and expansion of modern irrigation systems in these areas has created favourable environments for many plant species adapted to extreme aridity. In this study, to compare plant diversity in the vicinity of 6 water towers in hyper-arid areas, at each site we conducted 5 floristic surveys on the basis of subjective sampling. The floristic data were analysed using biodiversity and statistical parameters. We recorded there 43 species of 22 families, with a good representation of the Poaceae (18.6%) and Asteraceae (14.0%). According to Raunkiaer’s classification, the plant cover is mainly composed of therophytes (41.8%), i.e. annual species that complete their development cycle within one growing season. The spectrum of various types of dispersal shows the dominance of flora by anemochorous species (70.7%). A chorological analysis of the vegetation in the area revealed the importance of the Saharo-Arabian element (41.9%), which confirms its adaptation to the environment of the hyper-arid zones of the Sahara. The analysis of abundance classes revealed the existence of 10 rare species (18.1%), 3 very rare species (4.9%), and one fairly rare species (1.3%). In conclusion, the environments surrounding water towers in hyper-arid areas require adequate management measures to preserve biodiversity in Saharan environments.
Intermittent mechanical loading on mouse tibia accelerates longitudinal bone growth by inducing PTHrP expression in the female tibial growth plate
Authors: McGarry Sarah , Kover Karen , Heruth Daniel P. , Dallas Mark , Jin Xinxin , Wu Shufang , De Luca Francesco
Published: August 2024

It is not clear as to whether weight bearing and ambulation may affect bone growth. Our goal was to study the role of mechanical loading (one of the components of ambulation) on endochondral ossification and longitudinal bone growth. Thus, we applied cyclical, biologically relevant strains for a prolonged time period (4 weeks) to one tibia of juvenile mice, while using the contralateral one as an internal control. By the end of the 4‐week loading period, the mean tibial growth of the loaded tibiae was significantly greater than that of the unloaded tibiae. The mean height and the mean area of the loaded tibial growth plates were greater than those of the unloaded tibiae. In addition, in female mice we found a greater expression of PTHrP in the loaded tibial growth plates than in the unloaded ones. Lastly, microCT analysis revealed no difference between loaded and unloaded tibiae with respect to the fraction of bone volume relative to the total volume of the region of interest or the tibial trabecular bone volume. Thus, our findings suggest that intermittent compressive forces applied on tibiae at mild–moderate strain magnitude induce a significant and persistent longitudinal bone growth. PTHrP expressed in the growth plate appears to be one growth factor responsible for stimulating endochondral ossification and bone growth in female mice.
Relationship between fatigue crack threshold K
max,th and K
1SCC
Authors: Vasudevan Asuri K. , Kujawski Daniel , Latanision Ronald M.
Published: August 2024

This article describes the relationship that relates the static threshold parameter of K
1SCC (at ∼10−10  m/s) to ΔK
th and K
max,th (at ∼10−10 m/cycle) under fatigue load at high R-ratio like R = 0.85. At these high R-ratios (>0.75), applied K
max > K
1SCC and the fracture path has a larger component of static fracture. 5083 Al alloy is adapted as an example to demonstrate this relationship at room temperature their relationship with and without GB-β anodic precipitates in inert and a 3.5 % NaCl solution environments. We are interested in the mechanical cyclic ΔK
th and K
max,th and quasi-static K
ISCC driving forces affecting the damage in the presence of a chemical environment due to anodic dissolution of the GB-β precipitates. Detailed discussions involve how these parameters are interrelated.
A property of the free Gaussian distribution
Authors: Fakhfakh Raouf , Alshahrani Fatimah
Published: August 2024

Let

𝒦
+

⁢

(
σ
)

=

{

ℙ

(
ϑ
,
σ
)

⁢

(

d
⁢
ζ

)

:

ϑ
∈

(
0
,

ϑ
+

⁢

(
σ
)

)

}

{{\mathcal{K}_{+}}(\sigma)=\{\mathbb{P}_{(\vartheta,\sigma)}(d\zeta):\vartheta%
\in(0,\vartheta_{+}(\sigma))\}}

be the Cauchy–Stieltjes Kernel (CSK) family generated by a probability measure σ which is non degenerate and has support bounded from above. Consider the concept of

V
a

{V_{a}}

-transformation of measures introduced in [A. D. Krystek and L. J. Wojakowski,
Associative convolutions arising from conditionally free convolution,
Infin. Dimens. Anal. Quantum Probab. Relat. Top. 8 2005, 3, 515–545] for

a
∈
ℝ

{a\in\mathbb{R}}

. We prove that

V
a

⁢

(

ℙ

(
ϑ
,
σ
)

)

∈

𝒦
+

⁢

(
σ
)

{V_{a}(\mathbb{P}_{(\vartheta,\sigma)})\in{\mathcal{K}_{+}}(\sigma)}

for all

a
∈

ℝ
∖

{
0
}

{a\in\mathbb{R}\setminus\{0\}}

if and only if the measure σ is of the free Gaussian (semicircle) type law up to affinity.
Triple weak solution for p(x)-Laplacian like problem involving no flux boundary condition
Authors: Kefi Khaled , Chung Nguyen Thanh , Abdelfattah Walid
Published: August 2024

In this paper, we consider a class of

p
⁢

(
x
)

{p(x)}

-Laplacian like problems with indefinite weight involving no flux boundary condition. Using variational techniques and the critical point theorem of Bonanno and Marano [4], we prove the existence of at least three weak solutions to the problem in Sobolev variable exponent spaces.
Study of a boundary value problem governed by the general elasticity system with a new boundary conditions in a thin domain
Authors: Boulaouad Abla , Djenaihi Youcef , Boulaaras Salah , Benseridi Hamid , Dilmi Mourad
Published: August 2024

The aim of this work is the study of a nonlinear boundary value problem which theoretically generalizes the Lamé system with disturbance in a thin 3D domain with friction and a generalized boundary condition. For the resolution of the considered problem and after the variational formulation, we construct an operator from the variational problem. Then we prove that this operator has certain properties which allows us to apply the theorem of existence and uniqueness of the solution of variational inequalities of the 2nd kind. Finally, using a change of scale, we transport the variational problem to an equivalent problem defined on a domain independent of the parameter

ζ

{{\zeta}}

and subsequently we obtain the limit problem and the generalized weak equations of the initial problem.
Some classification of affine homothetical surfaces of finite type in 𝕀
Authors: Senoussi Bendehiba
Published: August 2024

A Euclidean submanifold is said to be of Chen finite type if its coordinate functions are a finite sum of eigenfunctions of its Laplacian Δ.
In this paper, we classify two types of affine homothetical surfaces of finite type in isotropic 3-space

𝕀
3

{\mathbb{I}^{3}}

under the condition

Δ
⁢

r
i

=

λ
i

⁢

r
i

{\Delta r_{i}=\lambda_{i}r_{i}}

, where

(

r
i

)

{(r_{i})}

is the i-component function of the position vector r (

i
=

1
,
2
,
3

{i=1,2,3}

),

λ
i

∈
ℝ

{\lambda_{i}\in\mathbb{R}}

and Δ denotes the
Laplace operator.
On the stability of a double porous elastic system with visco-porous damping
Authors: Nemsi Aicha , Keddi Ahmed , Fareh Abdelfeteh
Published: August 2024

In this paper, we focused on a one-dimensional elastic system with a double porosity structure and frictional damping acting on both porous equations. We introduce two stability numbers

χ
0

{\chi_{0}}

and

χ
1

{\chi_{1}}

and prove that the solution of the system decays exponentially provided that

χ
0

=
0

{\chi_{0}=0}

and

χ
1

≠
0

{\chi_{1}\neq 0}

. Otherwise, we prove the absence of exponential decay. Our results improve the results of [N. Bazarra, J. R. Fernández, M. C. Leseduarte, A. Magaña and R. Quintanilla,
On the thermoelasticity with two porosities: Asymptotic behaviour,
Math. Mech. Solids 24 2019, 9, 2713–2725] and [A. Nemsi and A. Fareh,
Exponential decay of the solution of a double porous elastic system,
Politehn. Univ. Bucharest Sci. Bull. Ser. A Appl. Math. Phys. 83 2021, 1, 41–50].
Do body esteem and quality of life scores change with puberty signs or precocious puberty treatment?
Authors: Koca Serkan Bilge , Büyükyılmaz Gönül , Taş Demet
Published: August 2024

Objectives

Body esteem (BE) and quality of life (QOL) of girls aged 9–11 years may change depending on their puberty. We aimed to examine The Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) and the Body Esteem for Adolescents and Adults Scale (BESAA) for children.

Methods

The groups were determined as those whose puberty signs had not yet started (Group 1), those having with breast development stage 3 and/or larger (Group 2), and those who had received gonadotropin-releasing hormone agonist (GnRHa) treatment for at least 6 months (Group 3).

Results

A total of 145 girls (Group 1: 41, Group 2: 56, Group 3: 48), were included. The PedsQL scores of the Group 1 was higher than Group 2 (78.5 ± 10.3 vs. 70.1 ± 14.2; p=0.008). The PedsQL scores of the Group 1 was higher but not statistically different from Group 3 (78.5 ± 10.3 vs. 74.2 ± 14.3; p=0.401). The PedsQL scores of Group 2 was not statistically different from Group 3 (p=0.354). There was no statistical difference in BESAA scores between groups (p=0.291). Group 1’s PedsQL Health and Activity subscale score was higher than Group 2 (p=0.002).

Conclusion

The QOL of the girls with PP was found to be lower than their healthy peers. Health and Activity-related QOL scores were found to be lower in the untreated group, indicating that girls with PP were probably significantly disturbed by their puberty-related physical development at the onset of the disease.
A novel portfolio optimization method and its application to the hedging problem
Authors: Halidias Nikolaos
Published: August 2024

In this article we will propose a novel, self-financing, dynamic and path dependent portfolio trading strategy
which is based on the well known principle “sell high – buy
low”. Trading strategies are important also for the hedging
problem selling/buying an option. The main problem of the writer
of an option is how to invest the amount that she has received
selling the option therefore the proposed trading strategy play an
important role here. We will see that the hedging problem reduces
to an optimization one and therefore the portfolio optimization
and the hedging problem are closely related. We will also propose
a deterministic portfolio selection method (i.e., without making
any assumption-guess about the assets) and a notion of a
deterministic fair price of an option.
Optimal oversampling ratio in two-step simulation
Authors: Naidu Srinath R. , Venkiteswaran Gopalakrishnan
Published: August 2024

This paper analyses a novel two-step Monte Carlo simulation algorithm to estimate the weighted volume of a polytope of the form

A
⁢
z

≤
T

{Az\leq T}

. The essential idea is to partition the columns of A into two categories – a lightweight category and a heavyweight category. Simulation is done in a two-step manner where, for every sample of the lightweight category variables we use multiple samples of the heavyweight category variables. Thus, the heavyweight category variables are oversampled with respect to the lightweight category variables and increasing samples of the heavyweight variables at the expense of the lightweight variables will lead to a more efficient Monte Carlo method. In this paper we present a fast heuristic approximate for estimating the optimal oversampling ratio and substantiate with experimental results which confirm the effectiveness of the method.
Optional strong semimartingale inequalities for the strong Snell envelopes
Authors: Haddadi Mouna , Ouknine Youssef
Published: August 2024

On finite time interval

[
0
,
T
]

{[0,T]}

, let X be an optional semimartingale of class

(
D
)

{(D)}

, and Z its strong Snell envelope, which is the smallest optional strong
supermartingale bounding X above (except on evanescent set). In this article, we provide the several characterizations of strong Snell envelopes to establish the main result which is the following inequality:

∥

Z
1

-

Z
2

∥

ℍ
p

≤

C
p

⁢

∥

X
1

-

X
2

∥

ℍ
p

,

\|Z^{1}-Z^{2}\|_{\mathbb{H}^{p}}\leq C_{p}\|X^{1}-X^{2}\|_{\mathbb{H}^{p}},

where

X
1

{X^{1}}

and

X
2

{X^{2}}

are two optional semimartingales of class

(
D
)

{(D)}

belonging to the space

ℍ
p

{\mathbb{H}^{p}}

(

p
>
1

{p>1}

),

Z
1

{Z^{1}}

and

Z
2

{Z^{2}}

are their Snell envelopes,

C
p

{C_{p}}

is an absolute constant.
New sites and challenges in prehistoric archaeology of Uruguay: recurrent occupations in caves, rockshelters and earthen mounds
Authors: Suárez Rafael , Melián Julia , Barceló Flavia , Volarich Jenny , Lugo Ismael , Rey Federico
Published: August 2024

Systematic investigation of caves and rockshelters in Uruguay is revealing the archaeological importance of these sites and their association with earthen mounds. Multiple periods of human occupation at Tamanduá rockshelter are revealed through stratigraphic analysis, and radiocarbon dates suggest recurrent occupation from the Early Holocene up to the historic period.
Bases antropológicas e expressões mundanas da busca patrimonial: memória, tradição e identidade
Authors: Candau Joël
Published: August 2024

Bases antropológicas e expressões mundanas da busca patrimonial: memória, tradição e identidade
Uma alma provida de janelas: O Teatro da Memória através de um itinerário imaginário a L‘idea del teatro de Giulio Camillo
Authors: Bussoletti Denise Marco
Published: August 2024

Uma alma provida de janelas: O Teatro da Memória através de um itinerário imaginário a L‘idea del teatro de Giulio Camillo
PROSPECTS OF THE LUBLIN TRIANGLE AFTER THE GRAIN DEAL FAILURE
Authors: Matyukhin Denis ,   Diplomatic Academy of the Ministry of Foreign Affairs of the Russian Federation, Klepatskii Lev ,   Diplomatic Academy of the Ministry of Foreign Affairs of the Russian Federation
Published: August 2024

The article analyses the current state of the Lublin Triangle with the forum facing a serious challenge of stability and unity for the first time after Russia’s withdrawal from the grain deal. The study focuses on both some statements of the Polish, Lithuanian and Ukrainian presidents within the framework of the Lublin Triangle and a number of trilateral declarations that have been adopted since the establishment of the format on July 28, 2020. The study points out the history of the Lublin Triangle development, as well as the ideological motives that prompted the Polish leadership to take the initiative to convene the forum. The article underlines that the Lublin Triangle status against the backdrop of the armed conflict in Ukraine was noticeably undermined after the Black Sea Grain Initiative failure, which, among other things, has already escalated tensions between Poland and Ukraine. The study concludes that the grain deal cancellation exposed the longstanding contradictions of the Lublin Triangle members, demonstrated Poland’s unwillingness to harm its own economic interests for the sake of supporting Ukraine and proved that the forum transformation into a unified and mutually beneficial union from a political, financial and cultural point of view is unlikely even in the distant future.
A novel splicing variant in ABCA1 in the first reported Hong Kong Chinese patient with high-density lipoprotein deficiency
Authors: Wong Cheuk Lik , Hung Ling Yin , Siu Wai Kwan Carol , Tam Vicki Ho Kee , Mak Chloe Miu
Published: August 2024

Low high-density lipoprotein cholesterol (HDL-C) is a risk factor for cardiovascular disease. Very low HDL-C levels (less than 20 mg/dL), however, were uncommonly seen and can be due to genetic defects involving the metabolic pathway of high-density lipoprotein (HDL). We encountered a 50-year-old Chinese man who was only noticed to have extremely low HDL-C levels after surviving recurrent episodes of myocardial infarction. Further workup revealed the undetectable level of apolipoprotein A-I, the absence of HDL on gel electrophoresis, and a novel heterozygous splicing variant in the ABCA1 gene, which was predicted to be pathogenic by in silico analysis. To the best of our knowledge, this is the first reported Hong Kong Chinese with ABCA1 deficiency and probable Tangier disease. The association of ABCA1 deficiency/Tangier disease and accelerated atherosclerosis is discussed.

Learning points

Clinicians should be aware of the differential diagnoses of very low HDL-C, which could be divided into genetic and acquired causes.

Genetic low HDL syndromes include apoA-I deficiency, Tangier disease, and familial LCAT deficiency, each of which has characteristic clinical features and can be differentiated from the other further by apoA-I measurement, lipoprotein analysis, and genetic testing.

Patients with ABCA1 deficiency and Tangier disease are at risk of premature coronary artery disease and should be aggressively screened and treated for cardiovascular risk factors and established cardiovascular diseases.

Revascularization strategy and indications for coronary artery bypass grafting in patients with Tangier disease and coronary artery disease follow that as for patients without Tangier disease.
REPRODUCTIVE AGEING: BGP-15 mitigates adverse impacts of aging on sperm quality, fertility, and offspring health in male mice
Authors: Gonzalez Macarena B , Campugan Carl A , Connaughton Haley S , Andreas Eryk , Winstanley Yasmyn E , Williams Elisha J , Dorian Camilla L , Robertson Sarah A , Shoubridge Cheryl , Robker Rebecca L
Published: August 2024

In Brief

Aging in men is associated with diminished sperm quality and a higher incidence of altered fetal development and miscarriage in resultant pregnancies. This study in mice identifies a therapeutic compound that, when administered to aged males, improves sperm quality, subsequent embryo development and post-natal offspring health.

Aging in men is associated with diminished sperm quality and a higher incidence of altered fetal development and miscarriage in resultant pregnancies. We used a mouse model of advanced paternal age to characterize embryonic development in older male mice and tested whether pre-conception treatment with the mitochondrial activator BGP-15 improves reproductive outcomes in old males. Like older men, reproductively old male mice had higher levels of sperm DNA damage and delayed pre-implantation development, associated with a reduced fetal weight and placental weight. Analysis of neonatal outcomes of in vivo-conceived offspring found that pups sired by old males were smaller, had delayed locomotor development, and increased mortality. BGP-15 treatment for 5 days prior to conception reduced sperm DNA oxidation levels and improved on-time embryo development after IVF and pup survival. BGP-15 treatment for 3 weeks prior to conception improved on-time pre-implantation embryo development and fetal viability and increased fetal size in pregnancies sired by old males. These results validate that ageing negatively affects male fertility and offspring physiology and indicates that pre-conception treatment with BGP-15 has the potential to improve sperm quality as well as early embryo development and post-natal health.
Perspectivas en prótesis oculares
Authors: D’Antone Valeria Andrea , Márquez Martha Lucila
Published: August 2024

La pérdida de uno o ambos de los globos oculares, representa un desafío significativo para la calidad de vida y el bienestar psicosocial de millones de personas en todo el mundo. En este contexto, la tecnología de las prótesis oculares ha emergido como un campo de investigación y desarrollo crucial, ofreciendo soluciones innovadoras para aquellos que han perdido su capacidad visual. Este working paper, resultado del trabajo del diplomado de prótesis oculares ofrecido en 2023 por la Facultad de Optometría de la Universidad Santo Tomás. Este diplomado responde a las necesidades del contexto social colombiano teniendo en cuenta inexistente oferta de formación en esta area. Por esta razón l diplomado propone brindar pautas para la valoración integral de la cavidad y la funcionalidad tanto de los párpados como de los anexos oculares, sensibilizar a los profesionales de la salud visual sobre la importancia del abordaje psicológico en la etapa inicial de manejo de un paciente con anoftalmia y de esta manera aumentar las de una adaptación exitosa.
Uses and Appropriation of Technologies in Initial Teacher Training Centers: A Comparative Study in Uruguay and Chile
Authors: Questa-Torterolo Mariela , Tejera-Techera Andrea , Cabrera-Borges Claudia
Published: August 2024

Objective. This article aims to compare the use and appropriation of digital technologies (ICT) by faculty in initial teacher training centers in Uruguay and Chile. Methodology. This research employed a mixed, sequential exploratory, quantitative-qualitative approach and data analysis, including two stages: (I) an online questionnaire administered to directors of centers in Uruguay and Chile; (II) interviews and discussion groups with members of selected centers in each country. Results. Results show that Chilean teachers most frequently use laptops, followed by cell phones. In Uruguay, the order is reversed. Concerning the use of ICT for pedagogical or professional development purposes, including videoconferencing, the creation of professional learning communities, and content creation, Chile is better positioned. Nonetheless, because of the pandemic and the adoption of other techniques, Uruguay has begun to increase its use of ICT for pedagogical purposes. Likewise, teachers have been identified both as facilitators of digital inclusion, thanks to their motivation, and as obstacles, due to fears, advanced age, and training. Conclusions. These findings show the relevance to keep intervening at the level of teacher education as a key focus to improve digital inclusion for pedagogical and professional development purposes.
E-commerce como estrategia comercial en micro y pequeñas empresas de calzado en El Porvenir, Perú
Authors: Coronado Salazar José Augusto
Published: August 2024

Objetivo: Determinar la relación que existe entre la adopción y el desarrollo del comercio virtual como estrategia comercial en el sector calzado del distrito El Porvenir (región La Libertad, Perú) durante el 2020. Métodos: El enfoque de la investigación fue cuantitativa, de tipo correlacional, con diseño no experimental a través de la aplicación de una encuesta como técnica y la elaboración de un instrumento para la recolección de datos, la cual fua validada a través del alfa de Cronbach; y posteriormente aplicada a una muestra de 286 fabricantes de calzados, y con la utilización de análisis de frecuencias, tablas cruzadas, coeficiente de correlación de Spearman, y el estadístico Chi-cuadrado. Resultados: El 56 % de los encuestados coincidió en reconocer la importancia de implementar una página web que le permitiera ampliar sus canales de ventas para mejorar sus ingresos entre un 60 % y 70 %. Conclusión: Los fabricantes que implementaron el e-commerce mejoraron su penetración de mercado positivamente, obteniendo un aumento significativo sobre sus ventas e ingresos.
Comparing signs and symptoms of dry eye treated with organic versus conventional lubricant eye drops
Authors: Friederich Dan
Published: August 2024

Purpose: This study aimed to investigate and compare changes in symptoms, signs, and clinical tests between two different lubricant eye drop treatments in patients with dry eye secondary to Meibomian gland dysfunction (MGD). Methods: This prospective clinical study included 20 symptomatic patients with MGD-induced dry eye. Participants who were diagnosed with dry eye were treated with either a certified organic artificial tear (AT) (O group) or a non-organic AT (C group) for 4 weeks and re-evaluated. Both treatments consisted of the same active ingredient, glycerin. The findings from the first and second visit were assessed. Differences between the effect of each treatment on signs and symptoms were analyzed. Dry eye symptoms, subjective wellness, tear break-up time (TBUT), tear osmolarity, and lid margin assessment were the variables evaluated. Results: Both treatment groups demonstrated improvements in objective tests, symptoms, and wellness. A larger percentage of patients in the C group reported symptomatic improvement, which was greater than in the O group. The O group exhibited a higher average improvement in wellness as well as greater improvement in TBUT and tear osmolarity than the C group. Conclusion: Conventional and organic lubricant eye drops both achieved clinical improvements in the signs and symptoms of MGD-induced Evaporative dry eye (EDE). Organic eye drops demonstrated a greater effect on overall wellness, TBUT, and tear osmolarity.
Evisceration of the small bowel through the perineal hernia
Authors: Edgar Patricio,1 Ramírez Morales , Carlos Emmanuel Xicohténcatl Xicohténcatl , Natalie Signoret Limiñana , Armando Mansilla Alba , Elias Gallardo Navarro , Jorge Fernández Álvarez
Published: August 2024

Introduction: Perineal hernias are an uncommon pathology, occurring mainly in women, it is also a result after abdominoperineal resection for rectal cancer occurring in less than 1 % or in pelvic exenteration in less than 10 %. Case report: 93-year-old female, with a history of abdominoperineal resection, presented to the emergency department for small bowel evisceration with intestinal ischemia secondary to perineal hernia, with abdominal repair of the pelvic floor and the use of mesh. Discussion: The diagnosis is clinical, but we can rely on diagnostic images, such as computed tomography or magnetic resonance imaging. Conclusion: It is important to know the probable root cause and its therapeutic options, taking into account the surgical technique that can be coupled to the surgeon's individual experience.
ПРИРОДНО-РЕСУРСНІ АКТИВИ ЯК ФАКТОР ЗАБЕЗПЕЧЕННЯ ЯКОСТІ ЖИТТЯ НАСЕЛЕННЯ ТЕРИТОРІАЛЬНИХ УТВОРЕНЬ
Authors: БИСТРЯКОВ Ігор , КЛИНОВИЙ Дмитро , КОРЖУНОВА Наталія
Published: August 2024

Визначено поняття природно-ресурсного активу як інституціоналізовану в господарський процес і уречевлену в матеріальній та нематеріальній формах складову природного багатства, яка несе в собі мінову і споживну вартість і в результаті залучення якої суб’єктами господарювання в економічну діяльність створюється додана вартість і одержуються потоки вигод від використання природних ресурсів як товарів, засобів і факторів виробництва.
Встановлено, що будь-якому природно-ресурсному активу одночасно притаманні дві групи ознак, з яких перша є характерною для нього як для капіталу природного походження, а друга – як для активу. На цій основі запропоновано узагальнену класифікацію природно-ресурсних активів. Їх ідентифіковано як капітал, що проявляє дуалістичну вартість використання / невикористання, бере учать у реконструктивному розвитку, з одного боку, як компонент довкілля і фактор формування середовища життєдіяльності людини, а з іншого – як ресурс і фактор резильєнтного розвитку територіальних утворень. Розкрито сутнісні ознаки резильєнтності господарських систем, за якими передбачено досягнення гомеостатичної рівноваги після порушення їх нормального функціонування і вихід на траєкторію зростання, що супроводжуватиметься розширенням і підвищенням якості компетенцій, результативності територіальної економіки за участі природно-ресурсних активів.
Охарактеризовано природно-ресурсні активи як інструменти просторового розвитку, які відграють у системі суспільного виробництва одночасно три ролі – сировинно-енергетичних ресурсів, засобів і факторів розвитку виробництва і товарно-ринкових відносин, а також  чинників якості життя. Ідентифіковано потенційні позитивні ефекти впливу інтеграції природно-ресурсних активів у господарський обіг на якість життя населення, у тому числі на посилення екологічної безпеки господарювання, формування привабливих умов для економічної діяльності й проживання населення, що сприятиме нормалізації демографічної ситуації в країні.
De las luchas por la memoria a la política de Estado. La democratización de la memoria
Authors: Suárez Andrés-Fernando
Published: August 2024

Este artículo pretende explicar cómo fue posible el tránsito de las luchas sociales por la memoria a su reconocimiento como una política de Estado. Para ello se entiende el Estado no como un aparato ni como una entidad inmutable y compacta sino como un campo de fuerzas y de lucha entre grupos dominantes y subordinados que cuando cambia provoca su reconfiguración. Se propone analizar las condiciones sociales y políticas entre la Ley 975 de 2005 (Ley de Justicia y Paz) y la Ley de Víctimas (Ley 1448 de 2011) como un proceso social y político, altamente contencioso, que condujo a la institucionalización de la política pública de memoria en Colombia como un deber del Estado basado en la democratización de la memoria.
Simulación Energética de un Sistema Termosolar de Torre Central para Magdalena, Colombia
Authors: Torres Suarez Evellyn Tatiana , Solís Chaves Juan Sebastián , Rodríguez Muñoz Andrea del Pilar
Published: August 2024

La energía solar de concentración ofrece una solución prometedora hacia una transición energética sostenible, ya que permite reducir el impacto de las emisiones de carbón en los procesos de generación de electricidad. Por tal razón, este estudio se orientó en evaluar la factibilidad técnica y energética para un sistema termosolar de torre central, cuya principal función sea la generación de energía eléctrica con una potencia total instalada de 88 MWe, en el norte del departamento de Magdalena, Colombia. En cuanto a la metodología aplicada, se empleó el software de simulación de desempeño System Advisor Model (SAM) que permitió evaluar la energía generada por el sistema bajo las condiciones meteorológicas del lugar. Los resultados encontrados señalan un rendimiento positivo que alcanzó 210,8GWh de energía eléctrica para un año, con un factor de capacidad del 30%, lo que permite concluir que la adopción de esta tecnología en Colombia sería promisoria para la diversificación de la matriz energética y la reducción de la dependencia de los combustibles fósiles usados en las plantas termoeléctricas.
Análisis tecnológico de la aviación para la transición energética
Authors: Ramirez Gonzalez Omar , Fula Rojas Manuel Alejandro
Published: August 2024

La transición energética global requiere un análisis del consumo de combustible líquido. Este estudio se enfoca en algunos aviones utilizados en Colombia, evaluando el consumo de combustible y las emisiones de CO2 por persona en los trayectos Bogotá-Medellín y Bogotá-San Andrés para un solo vuelo. Se analizan las diferencias estructurales y térmicas en la termodinámica interna de los motores turbofán y turboprop a través de la literatura. Se presentan figuras y tablas comparativas del consumo de combustible y generación de CO2 por persona para los aviones ATR72, A320 y A321. Se realizan entrevistas a expertos relacionados con el tema de la aeronáutica. Con lo anterior se explica por qué los vuelos regionales se benefician del uso de turboprop, mientras que los trayectos más largos prefieren turbofanes. Este análisis es relevante para la toma de decisiones en la industria aeronáutica de Colombia y en la lucha contra el cambio climático global.
Żelazne akinakesy ze zbiorów Muzeum Narodowego Ziemi Przemyskiej
Authors: Krzemińska Magdalena ,   Muzeum Narodowe Ziemi Przemyskiej, Burghardt Marcin ,   Muzeum w Jarosławiu Kamienica Orsettich
Published: August 2024

The National Museum of Przemyśl District houses three iron acinaces of unknown origin. The very good state of preservation of all three items allowed for a full formal and typological analysis. It was revealed that all three specimens represent forms that are dated to the 7 th –6 th centuries BC. Although these objects come from unknown contexts, they expand the source base of Scythian military artefacts, making them an excellent source for further detailed morphological and technological analyses of Scythian swords and daggers.
DESENVOLVIMENTO DE UM MODELO PARA ROTEIRO DE PRÁTICA LABORATORIAL PADRONIZADO:
Authors: Silva da Trindade Rayssa , De Lima Miranda Ruth , Nunes de Almeida Prado Rafael
Published: August 2024

Este artigo propõe-se a desenvolver um modelo padronizado de roteiros de práticas laboratoriais que possa atender a práticas de diferentes cursos em áreas distintas. Inicialmente, foi aplicado à disciplina de circuitos elétricos do Curso Técnico em Eletrotécnica do IFRN, motivo seria esse curso ser ofertada em quatro diferentes Campi do Instituto. Visto que também a disciplina é difundida e presente na maioria dos cursos técnicos e superiores da área de engenharia. Nas avaliações de curso do MEC, os avaliadores veem com bons olhos quando em cada laboratório se encontram presentes ou afixadas os respectivos roteiros de práticas desses laboratórios.  Visto que não estão presentes nestes espaços do campus central, surgiu a demanda de obter um modelo de experimento de laboratório para ser afixado e que deva auxiliar os docentes no planejamento pedagógico. O trabalho foi desenvolvido realizando-se uma pequena revisão bibliográfica dentre roteiros de prática, livros de práticas e materiais institucionais sobre o assunto, de modo a se fundamentar e verificar os elementos em comum e diferentes entre estes modelos. Partindo desse conhecimento o modelo de roteiro de laboratorial contém os elementos básicos obrigatórios e opcionais.
Prevalencia de consumo de sustancias psicoactivas en hombres que tienen relaciones sexuales con hombres, Colombia
Authors: Bedoya Mejia Sebastián , Cardona Arango Doris , Agudelo Cifuentes Maite Catalina , Ramos-Jaraba Sara Milena , Matagira-Rondón Giselly , Segura-Cardona Ángela M , Berbesí-Fernández Dedsy Yajaira
Published: August 2024

Introducción: El uso de sustancias psicoactivas en la población es un problema actual, que afecta a una gran parte de la humanidad, con diversas consecuencias.   Objetivo: Analizar los factores asociados al consumo de sustancias psicoactivas en hombres que tienen sexo con otros hombres (HSH) en tres ciudades de Colombia.   Materiales y Métodos: Este estudio descriptivo transversal utilizó el método de muestreo respondent-driven sampling y logró una muestra de 1301 HSH. Se evaluó la asociación entre las características sociodemográficas y personales y el consumo de sustancias psicoactivas mediante la prueba chi-cuadrado. Las razones de prevalencia se calcularon con sus intervalos de confianza del 95%. En el análisis multivariado, se empleó una regresión de Poisson con enlace logarítmico y estimador robusto, para explorar los factores asociados con el uso de sustancias psicoactivas. Resultados: La prevalencia de consumo de sustancias psicoactivas en el último año fue del 87%, predominando el consumo de alcohol, marihuana y poppers. Tener parejas ocasionales (RP: 0,44; IC 95% 0,29-0,67), asistir a lugares públicos o establecimientos como bares y saunas (RP: 3,39; IC 95% 2,34 - 4,91), el trabajo sexual y no usar condón en la última relación sexual (RP: 2,10; IC 95%: 1,37 - 3,22) son factores asociados con el consumo de estas sustancias. Discusión: Se evidencia una alta prevalencia de consumo recreativo de sustancias psicoactivas, incluso superior a la encontrada en población general.   Conclusión: Se confirma una alta prevalencia y asociación con conductas sexuales de riesgo, lo que requiere acciones de promoción y prevención para reducir el uso de estas sustancias.
Como citar este artículo: Bedoya Mejia Sebastián, Cardona Arango Doris, Agudelo Cifuentes Maite Catalina, Ramos-Jaraba Sara Milena, Matagira-Rondón Giselly, Segura-Cardona Ángela M, Berbesí-Fernández Dedsy Yajaira. Prevalence of psychoactive substance use in men who have sexual relationships with men, Colombia. Revista Cuidarte. 2024;15(2):e3477. https://doi.org/10.15649/cuidarte.3477
ORTHOPEDIC INJURIES IN MEN’S PROFESSIONAL SOCCER DURING THE CORONAVIRUS DISEASE PANDEMIC
Authors: Arliani Gustavo Gonçalves , da Silva Eli Henrique Rodrigues , Fares Hussein , Lara Paulo Henrique Schmidt , Pagura Jorge Roberto , Cohen Moisés
Published: August 2024

ABSTRACT Objective: To assess the incidence and characteristics of injuries that occurred in the 2020 season of the Paulista Football Championship during the novel coronavirus disease pandemic. Methods: We conducted a prospective study using an electronic questionnaire developed by the Medical Committee of the Paulista Football Federation. Results were sent to the team doctors of series A1 and A2 after each round of the Paulista Football Championship. Results: Series A1 and A2 presented 12.17 and 15.6 injuries, respectively, per 1000 gaming hours. The strikers were the most affected, with muscle injuries being the most frequent and the lower limbs being the most affected. Most injuries occurred within 31-45 minutes of playing; only 4.5% of injuries required surgery. Conclusion: There was no statistical difference in the comparison between pre- and post-pandemic conditions. In relation to the variables studied, the most injuries occurred in the lower limbs; the most common type of injury was muscle strain, followed by sprain and contusion. The most requested exam was MRI; most injuries were classified as moderate (8-28 days). There was no difference between pre- and post-pandemic conditions. Level of Evidence IV, Case Series.
Densidad de Células Ganglionares y Perfil del Microbioma Colónico en Síndrome de Pseudoobstrucción: una Serie de Casos
Authors: De La Sota-Zubeleta Leonidas , Ascuña-Durand Kasandra , De La Sota-Vilca Leonell , Salazar-Sanchez Renzo
Published: August 2024

Antecedentes: Durante la práctica clínica se ha observado que los casos de vólvulo sigmoideo pueden tener complicaciones posteriores a su tratamiento correspondientes al síndrome de pseudoobstrucción colónica aguda (ACPO, por sus siglas en inglés) y crónica (CIPO, por sus siglas en inglés), siendo mucho más frecuente su forma aguda también llamado síndrome de Ogilvie. No se comprende completamente la causa y el mecanismo subyacente al desarrollo de estas condiciones. Aunque se han descrito posibles causas en otros estudios, la investigación enfocada en el estado de las células ganglionares y el microbioma del paciente es limitada. Este estudio tiene como objetivo aportar a la literatura médica el conteo de las células ganglionares y la diversidad microbiana de seis pacientes diagnosticados con pseudoobstrucción colónica aguda y crónica observada en pacientes de la zona altoandina del sur del Perú.
Presentación de caso: El antecedente común que caracteriza y agrupa a los casos reportados es la sigmoidectomía previa por vólvulo de sigmoides, junto con la presencia de signos y síntomas de un cuadro obstructivo funcional agudo y crónico. En todos los casos, el diagnóstico clínico posterior al tratamiento de vólvulo sigmoideo fue ACPO o CIPO. Estos diagnósticos fueron confirmados mediante radiografía de abdomen y tomografía. Se inició un tratamiento médico conservador con Neostigmina. La falta de respuesta al tratamiento conllevó a realizar diversas técnicas quirúrgicas.
Conclusión: Todos los pacientes mostraron hipoganglionosis. Según el análisis del microbioma, en cuatro de ellos, el filo predominante fue Firmicutes y el enterotipo predominante fue Prevotella. En los otros dos pacientes, se observó un porcentaje elevado de Proteobacterias, con Bacteroides como enterotipo predominante. La relación de Firmicutes/Bacteroidetes promedio fue de 4.9. Nuestro estudio muestra la existencia de disbiosis bacteriana en dos pacientes con hipoganglionosis colónica, que podría estar relacionada con la fisiopatología del ACPO y del CIPO. Adicionalmente, reportamos alteraciones en la frecuencia relativa de bacterias asociadas al metabolismo de flavonoides.
Antioxidant depletion from a 2 mm high-density polyethylene geomembrane used in brine containment
Authors: Awad R. , Rowe R. K.
Published: August 2024

The depletion of antioxidants from a 2 mm high-density polyethylene geomembrane immersed in brine at seven temperatures (95, 85, 75, 65, 55, 40, and 25°C) for 28 months is reported. An Arrhenius model is used to predict the performance of the geomembrane at low site-specific temperatures. The antioxidant depletion times are reported for temperatures between 20 and 95°C. The solubility of the antioxidant and stabilizer packages, the oxidation by-products, and their susceptibility to hydrolysis are discussed. After 28 months of incubation, no oxidative degradation was observed for samples in the full brine solution even at 95°C. Morphological changes reduced the stress-crack resistance to a stable representative value without a reduction in the tensile elongation at break. The effect of the brine solution concentration on the depletion of antioxidants and stabilizers was investigated at 85°C. It was found that the depletion rate decreases with the increasing brine concentration.