bluuebunny/crossref_metadata_2025 huggingface dataset:
PEDAGOJİK SEVGİ EĞİLİMLERİ ÖLÇEĞİNİN UYARLANMASI: GEÇERLİK VE GÜVENİRLİK ÇALIŞMASI
Authors: Eroğlu Mehmet , Donmuş Kaya Vildan
Published: June 2021

Bu araştırmanın amacı Yin ve arkadaşları (2019) tarafından geliştirilen pedagojik sevgi eğilimleri ölçeğinin Türk kültürüne uyarlanmasıdır. Orijinal formu 6 boyut ve 29 madde olan ölçeğin uyarlama çalışmalarının ilk aşamasında dilsel eşdeğerlik çalışması yapılmıştır. Araştırmanın verilerini toplamak için Fırat Üniversitesi Bilimsel Araştırma ve Yayın Etiği Kurulu’ndan etik uygunluk raporu (Tarih: 29/12/2020, Sayı: 432967) alınmıştır. Ölçeğin geçerlik ve güvenirlik çalışmaları için 291 sınıf öğretmeninden veri toplanmıştır. Yapılan açımlayıcı faktör analizinde, 7 madde elenerek toplam varyansın %67,71’ ini açıklayan 6 boyutlu ölçek elde edilmiştir. Yapılan doğrulayıcı faktör analizinde iyi ve mükemmel uyumu gösteren (ꭓ 2 /sd = 1.77, CFI= .95, TLI= .95, RMSEA= .050, RMR= .017, SRMR= .049 uyum indeksi değerleri elde edilmiştir. Oluşan faktörler ölçeğin orijinal hali dikkate alınarak bağ ve adanmışlık, çeşitliliğin kabulü, samimiyet, empati, sınıf topluluğunun kabulü ve nezaket, bağışlama olarak adlandırılmıştır. Bu sonuçlar ölçme aracının yapısal geçerliğinin olduğunu ortaya koymuştur. Ölçeğin güvenirlik analizleri için Cronbach Alpha iç tutarlılık katsayısı hesaplanmıştır. Cronbach Alpha iç tutarlılık katsayıları, bağ ve adanmışlık boyutu için .85, çeşitliliğin kabulü boyutu için .73, samimiyet boyutu için .85, empati boyutu için .92, sınıf topluluğunun kabulü ve nezaket boyutu için .83, bağışlama için .75, ölçeğin geneli için ise . 92 olarak hesaplanmıştır. Araştırma sonuçları uyarlanan pedagojik sevgi eğilimleri ölçeğinin öğretmenlerin pedagojik sevgi düzeylerini ölçebilecek geçerli ve güvenilir bir ölçme aracı olduğunu göstermektedir.
Relationship Of Knowledge, Attitude, And Perception Of Disease With The Utilization Of Health Services For Non-Convertive Diseases In Rsud Haji Makassar
Authors: Et. al. Muh. Yusri Abadi,
Published: June 2021

Currently, the health challenge in Indonesia is the epidemiological transition, which is known as three disease burdens, namely the high prevalence of infectious diseases, the increase in non-communicable diseases and diseases that should have been resolved before but have re-emerged. Non-communicable diseases require more attention, as the productive age increases in Indonesia, several factors such as lifestyle, diet, and others make non-communicable diseases increase, so health needs to receive attention in increasing the degree of public health, one of which is health services. This study aims to determine the relationship between knowledge, attitudes, and perceptions of pain with the utilization of health services for patients with non-communicable diseases at Regional General Hospital (RSUD) Haji Makassar. This research is a quantitative study with an observational approach using a cross sectional design. The population in this study were 1037 patients with non-communicable diseases at Haji Makassar Hospital. The sample selection used accidental sampling technique, in order to obtain a sample of 87 people. Data analysis used univariate and bivariate analysis. The results of this study indicate that knowledge of non-communicable diseases (ρ = 0.000), attitude of officers (ρ = 0.100), and perception of pain (ρ = 0.016). Suggestions to the hospital to make improvements regarding the condition of the hospital, the availability of facilities, types, or variations of health services that are more complete. Doctors, nurses or officers give more special attention to the patient's condition when providing services and further explain the patient's health condition.
Pengaruh Penambahan Garam pada Perubahan Karakteristik Kimia dan Pertumbuhan Bakteri pada Ikan Sepat Rawa (Trichogaster trichopterus)
Authors: Puspitasari Findya , Aisyah Siti , Agustiana Wilianti Siti , Syech Albarah Kemas , Adawyah Rabiatul
Published: June 2021

Penelitian ini bertujuan untuk mengetahui pengaruh penggaraman dengan konsentrasi yang berbeda terhadap karakteristik kimia dan pertumbuhan bakteri pada ikan sepat rawa (Trichogaster trichopterus). Perlakuan yang diberikan adalah tanpa penambahan garam (A) sebagai kontrol, garam 5% (B), garam 10% (C) dan garam 15% (D). Analisis kadar air menggunakan metode pengeringan, analisis kadar protein menggunakan metode Kjeldahl, analisis asam amino menggunakan high performance liquid chromatography (HPLC) dan analisis pertumbuhan mikroba menggunakan metode angka lempeng total (ALT). Perlakuan terbaik adalah perlakuan D penambahan garam dengan konsentrasi 15% menghasilkan kadar air ikan sepat rawa sebesar 61,35%, kadar protein 31,61%, dan ALT 5,87 log10 CFU/mL. Profil asam amino esensial yang tertinggi pada perlakuan B yaitu lisina sebesar 2,20% dan asam amino non esensial yang tertinggi pada perlakuan B yaitu asam glutamat 4,34%.
Pengaruh Perbedaan Konsentrasi Garam terhadap Asam Glutamat Terasi Udang Rebon (Acetes sp.)
Authors: Wisnu Murti Rizki , Sumardianto Sumardianto , Purnamayati Lukita
Published: June 2021

Udang rebon pada umumnya digunakan sebagai bahan baku produk produk penyedap rasa, antara lain terasi udang, petis, dan diolah menjadi rebon kering. Udang rebon memiliki rasa yang gurih. Fermentasi secara sederhana menghasilkan berbagai produk, salah satunya terasi. Fermentasi garam akan menimbulkan rasa gurih, karena komponen pada udang rebon mengalami pemecahan akibat aktivitas enzim protease. Tujuan penelitian ini adalah untuk menentukan karakteristik terasi berdasarkan perbedaan konsentrasi garam dan menentukan konsentrasi garam terbaik. Metode penelitian menggunakan rancangan acak lengkap. Perlakuan pada penelitian adalah perbedaan konsentrasi garam dengan konsentrasi 2, 8, dan 14%. Parameter yang diamati adalah TPC BAL, pH, aw, kadar garam, asam glutamat, kadar air, dan organoleptik. Data parametrik dianalisis dengan uji ANOVA dan dilanjutkan uji BNJ, sedangkan data non-parametrik dianalisis dengan Kruskal-Wallis dan dilanjutkan dengan uji lanjut Mann-Whitney. Hasil penelitian menunjukkan bahwa terasi udang rebon dengan konsentrasi garam 2, 8, dan 14% mempunyai perbedaan yang nyata (p<5%) terhadap kadar garam, asam glutamat dan kadar air namun tidak mempunyai perbedaan yang nyata (p>5%) terhadap pH dan aw. Formulasi terasi udang rebon terbaik pada penelitian ini dengan penambahan garam 2% dinilai dari asam glutamat 13,68%±0,10 dan uji organoleptik dengan selang kepercayaan 8,61<μ<8,81.
Sahabat Alam berkolaborasi dengan nelayan Kondang Merak mengelola wisata alam berbasis konservasi di Desa Sumberbening Kecamatan Bantur Kabupaten Malang
Authors: Septyawati Iis Tri , Sukamto Sukamto , Ruja I Nyoman , Eskasasnanda I Dewa Putu
Published: June 2021

The research aims to describe (1) the historical pioneering journey of Sahabat Alam at Kondang Merak Beach, (2) the characteristics of Sahabat Alam, (3) an overview of conservation-based nature tourism at Kondang Merak Beach, (4) the role of Sahabat Alam in collaborating with Kondang fishermen. Peacock through conservation-based nature tourism through empowerment. The approach and type of research in this research is descriptive qualitative. The results of this study are that the role of Sahabat Alam in collaborating and implementing the empowerment of Kondang Merak fishermen through conservation-based nature tourism, namely opening new jobs for fishermen as local guides, providing new income allocations through natural tourism package services such as providers of mangrove tree seedlings, providers of reef media. reef and boat rental services. In addition, Sahabat Alam plays a role in providing education and various trainings on conservation and tourism.

Penelitian memiliki tujuan untuk mendeskripsikan (1) perjalanan rintisan sejarah Sahabat Alam di Pantai Kondang Merak, (2) karakteristik Sahabat Alam, (3) gambaran umum wisata alam berbasis konservasi di Pantai Kondang Merak, (4) peran Sahabat Alam dalam berkolaborasi dengan nelayan Kondang Merak melalui wisata alam berbasis konservasi melalui pemberdayaan. Pendekatan dan jenis penelitian dalam penelitian ini yaitu kualitatif deskriptif. Hasil penelitian ini adalah bahwa peran Sahabat Alam dalam berkolaborasi dan pelaksanaan pemberdayaan nelayan Kondang Merak melalui wisata alam berbasis konservasi yaitu membuka lapangan pekerjaan baru bagi nelayan sebagai local guide, menyediakan alokasi pendapatan baru melalui jasa paket wisata alam seperti penyedia bibit pohon mangrove, penyedia media terumbu karang dan jasa sewa perahu. Selain itu Sahabat Alam berperan dalam memberikan edukasi dan berbagai pelatihan tentang konservasi dan wisata.
Model problem based learning dengan geospatial information: Implementasi dalam pembelajaran Geografi dengan untuk kemampuan spatial thinking
Authors: Dewi Yuni Kartika Sita , Handoyo Budi , Purwanto Purwanto
Published: June 2021

Berpikir spasial lekat dengan geografi karena salah satu pendekatan geografi merupakan pendekatan keruangan (spasial). Kemampuan berpikir spasial menjadi penting karena setiap fenomena geografi yang dikaji mencakup suatu ruang yang mempengaruhi ruang lainnya. Kegiatan pembelajaran yang dapat membangun kemampuan berpikir spasial yaitu menggunakan model Problem Based Learning menggunakan informasi geospasial sebagai media. Penelitian ini bertujuan untuk mengetahui pengaruh model Problem Based learning menggunakan informasi geospasial terhadap kemampuan berpikir spasial siswa kelas X IIS di SMAN Bandarkedungmulyo Jombang. Rancangan penelitian ini menggunakan eksperimen semu pretest postest. Penelitian ini menggunakan instrumen berupa soal essaisebanyak 8 butir untuk mengukur kemampuan berpikir spasial. Hasil penelitian menunjukkan bahwa model Problem Based Learning menggunakan media informasi geospasial berpengaruh terhadap kemampuan berpikir spasial.
Akulturasi budaya Tembang Lir-ilir sebagai media dakwah Sunan Kalijaga
Authors: Rumpaka Rori Amelya , Ayundasari Lutfiah
Published: June 2021

Islam is mostly embraced by Indonesians. The majority of Indonesians adhere to the largest religion in the world. Islam entered the archipelago through peaceful channels in accordance with the religious mission, namely rahmatan li al-'ālamīn. Which is Islam as a religion that embraces or protects all people and other things. Likewise with the culture in Indonesia. Indonesian culture has existed since time immemorial. Various cultures passed on from their ancestors to their successors. Indonesia has a variety of cultural features that need to be preserved and maintained. This is what makes Indonesian society thick with culture. Islam entering Indonesian territory is not easy. Because the majority of people still adhere to and are thick with culture. Therefore, the figures who spread the religion of Islam must know the character of Indonesian society. Using the method of acculturating existing cultures in Indonesia with Islamic religious values is the right way to spread Islam.

Agama Islam dianut sebagian besar oleh masyarakat Indonesia. Mayoritas masyarakat Indonesia menganut agama yang dianut terbesar di dunia ini. Islam masuk ke wilayah Nusantara melalui jalur damai sesuai dengan misi agama yakni rahmatan li al-‘ālamīn. Yang mana Islam sebagai agama yang merangkul atau mengayomi semua umat dan hal lainnya. Begitu pula dengan kebudayaan yang ada di Indonesia. Kebudayaan Indonesia sudah ada sejak dahulu kala. Beragam kebudayaan diwariskan para leluhur kepada penerusnya. Indonesia memiliki beragam corak kebudayaan yang perlu dilestarikan dan dijaga keberadaannya. Hal tersebut yang menjadikan masyarakat Indonesia kental akan budaya. Agama Islam masuk ke wilayah Indonesia tidak mudah. Dikarenakan mayoritas masyarakat masih menganut dan kental akan budaya. Maka dari itu, para tokoh penyebar agama Islam harus mengetahui karakter masyarakat Indonesia. Menggunakan cara mengakulturasi budaya yang ada di Indonesia dengan nilai-nilai agama Islam merupakan cara yang tepat untuk penyebaran agama Islam.
Parameter Tuning of Brushless DC Motor for Improving Control Effect with Worm Algorithm
Authors: Qin Jianhua , Wang Wenrong , Liu Xiao
Published: June 2021

Aiming at the problem of low control precision and small applicable scope caused by adjusting control parameters in Ziegler-Nichols (ZN) method, a parameter tuning method based on Worm algorithm (WOA) is proposed for Brushless DC motor. Firstly, the model of speed control is established by proportional integral method for Brushless DC motor with two - phase conduction and three - phase full bridge drive. Then the fitness function of the controller is constructed by the Integral Absolute Error (IAE). Finally, the early optimization process, the later movement rule and the peak extraction rule are determined for WOA, and the controller parameter tuning process is designed. Simulation results under constant and sinusoidal conditions show the effectiveness of the proposed method. WOA was compared with ZN, genetic algorithm (GA), differential evolution algorithm (DE) and particle swarm optimization algorithm (PSO) in the experiment. The experimental results show that the control effect (CE) of WOA under uniform speed has been improved by 2.56% on average, and has been improved by 16.93% on average under sinusoidal speed. Compared with previous methods, this method can be used for parameter adjustment of complex control with higher control precision.
SARS-CoV-2-related Multisystem Inflammatory Syndrome in Children
Authors: Al Maskari Nawal , Al Mukhaini Kholoud , Al Abrawi Safiya , Al Reesi Mohammed , Al Abulsalam Juhaina , Elsidig Nagi
Published: June 2021

On 27 April 2020, the National Health Service England issued an emergency alert for a new condition owing to the observation of an increasing number of cases of a COVID-19-related hyperinflammatory syndrome termed multisystem inflammatory syndrome in children (MIS-C). Some of the presenting symptoms appeared similar to the Kawasaki disease and toxic shock syndrome. We report the cases of six children fitting the criteria of MIS-C, admitted to Royal Hospital and Sohar Hospital, Oman, between the months of June and July in 2020. Four of these patients required admission at the paediatric intensive care unit for inotropic support while two were admitted to the paediatric ward on suspicion of appendicitis. MIS-C has been reported in a small number of individuals below the age of 21 years with a median age of 9–10 years. Five of the current patients were aged less than the median age reported in the existing literature. All of the patients showed complete recovery with supportive management, intravenous immunoglobulin and steroids, with one patient requiring interleukin-6 inhibitor (tocilizumab).

Keywords: COVID-19; SARS-CoV-2; Kawasaki Disease; Multisystem Inflammatory Syndrome in Children; Toxic Shock Syndrome; Case Report; Oman.
Outcomes of Infants Undergoing Modified Blalock-Taussig Shunt Procedures in Oman
Authors: Shaikh Samiuddin , Al-Mukhaini Khaloud S , Al-Rawahi Abdul Hakeem , Al-Dafie Omer
Published: June 2021

Objectives: A modified Blalock-Taussig (mBT) shunt procedure is a common palliative surgery used to treat infants and children with cyanotic congenital heart disease (CCHD). This study aimed to report the outcomes of infants and children undergoing mBT shunt procedures in Oman. In addition, risk factors associated with early mortality, inter-stage mortality and reintervention were assessed. Methods: This retrospective cohort study was conducted from January 2016 to December 2018 at the National Heart Centre, Muscat, Oman. All paediatric patients with CCHD undergoing mBT shunt procedures as a primary palliative procedure during this period were included. Data were retrieved from electronic hospital records. Kaplan-Meier survival curves were used to describe overall survival. Results: A total of 50 infants and children were included in the study. The in-hospital mortality and inter-stage mortality rates were 10% and 6.7%, respectively. Preoperative mechanical ventilation (odds ratio [OR]: 3.00, 95% confidence interval [CI]: 1.98–4.76; P = 0.007) and cardiopulmonary bypass (OR: 4.09, 95% CI: 2.44–6.85; P = 0.002) were significant risk factors for early mortality. In-hospital and interval surgical reintervention rates were 12% and 13.3%, respectively. Following the primary shunt procedure, the median time to second-stage surgery was 15.5 months (range: 5.0–34.0 months). Conclusion: The findings of this study support those reported in international research regarding the risks associated with mBT shunt surgeries. In particular, preoperative mechanical ventilation and cardiopulmonary bypass were significant risk factors for early mortality.

Keywords: Pediatrics; Heart Diseases, congenital; Cardiovascular Surgical Procedures; Modified Blalock-Taussig Procedure; Patient Outcome Assessment; Hospital Mortality; Risk Factors; Oman.
Otel İşletmelerinde Bilgi/Deneyim Paylaşım Süreci: Bir Ölçek Geliştirme Çalışması
Authors: TÜRKAY Oğuz , KABADAYI Melih
Published: June 2021

Bu çalışmanın amacı, otel işletmelerinde örgütsel hafıza ve örgütsel öğrenme olgularının gelişiminde önemli bir role sahip olan, bilgi/deneyim paylaşımı ile ilgili geçerli ve güvenilir bir ölçek geliştirmektir. Deneyim paylaşım sürecinin ne, neden ve nasıl’ına yanıt üretecek şekilde deneyim paylaşım güdüleri, deneyim paylaşım kanalları ve paylaşılan deneyim türlerini kapsayan 30 ifadenin tutarlı bütünselliği, 2015-2016 yıllarında 333 otel çalışanından elde edilen veri üzerinden değerlendirilmiştir. Ölçeğin kapsam geçerliği uzman görüşleri aracılığıyla, yapı geçerliği ise Açımlayıcı Faktör Analizi (AFA) ve Doğrulayıcı Faktör Analizi (DFA) kullanılarak değerlendirilmiştir. Güvenirliğin belirlenmesinde ise Cronbach Alpha, Rho-A ve Composite Reliability ve Fornell-Larcker Criterion değerleri incelenmiştir. Gerçekleştirilen analizler sonucunda ölçülen yapının geçerli ve güvenilir bir ölçme aracı olduğu tespit edilmiştir.
İş Stresinin Örgüt İçi Çatışmaya Etkisi: Sivil Havacılık Çalışanları Üzerine Bir Araştırma
Authors: KAYNAK İnan
Published: June 2021

Bu araştırma iş yerindeki stresin çatışmaya olan etkisini ölçmek için yapılmıştır. Araştırma için 2 boyut ve 8 maddeden oluşan çatışma ölçeği ile iki boyut ve 9 maddeden oluşan iş stresi ölçeği kullanılmıştır. Bu kapsamda İstanbul Hava Limanında görevli yolcu hizmetleri memurları ile anket çalışması yapılmıştır. 416 kişiden alınan cevaplarla veri seti oluşturulmuştur ve veriler SPSS 25.0 programında analiz edilmiştir. Çalışma sonuçlarına göre, iş stresinin alt boyutlarından zaman stresinin görev çatışmasını etkilediği fakat ilişki çatışmasını etkilemediği anlaşılmıştır. Yine iş stresinin alt boyutlarında zaman stresi ve iş kaygısının, çatışmanın alt boyutları olan görev ve ilişki çatışmasını pozitif yönde etkilediği sonucuna varılmıştır. Çalışma neticesinde ulaştığımız sonuçlar, literatürle uyumlu bir şekilde stresin çatışmayı etkilediğini ortaya koymuştur.
Applying joint theoretical experimental research to aptamer modeling
Authors:   Federal Research Center ”Krasnoyarsk Science Center SB RAS", Shchugoreva I.A. , Artyushenko P.V. ,   Federal Research Center ”Krasnoyarsk Science Center SB RAS", Tomilin F.N. ,   Siberian Federal University, Morozov D.I. ,   University of Jyväskylä, Mironov V.A. ,   Lomonosov Moscow State University, Moryachkov R.V. ,   Federal Research Center ”Krasnoyarsk Science Center SB RAS", Kichkailo A.S. ,   Federal Research Center ”Krasnoyarsk Science Center SB RAS"
Published: June 2021

The aim of the research. In this work we studied the structure of LC-18 DNA aptamer, which exhibits specifi c binding to lung adenocarcinoma cells. Obtaining the 3D structure of the aptamer is necessary for understanding the mechanism of binding of the aptamer to the target. Th erefore, the aim of the research was modeling of the LC-18 aptamer spatial structure using combination of theoretical methods: DNA folding tools, quantum-chemical calculations and molecular dynamic simulations. Material and methods. Th e secondary structure of the LC-18 aptamer was predicted by using OligoAnalyzer and MFold online soft ware under the conditions typical small-angle X-ray scattering (SAXS) experiment. Th e molecular modeling of the aptamer was carried out using the Avogadro program. For prediction of the structure two computational methods were used: quantum-mechanical method with third-order density-functional tight-binding (DFTB3) and molecular dynamics (MD) with force fi elds. Results. In this paper it was shown that molecular simulations can predict structures from the SAXS experiments. OligoAnalyzer and MFold web servers have been used to generate a set of several likely models. However, more accurate calculations have showed that these models do not predict the relative importance of isomers. Meanwhile, application of quantum-chemical and molecular dynamics calculations have showed reliable molecular structures which have a small deviations from the experimental SAXS curves. Conclusion. Th is study demonstrates the approach for modeling 3D structures of DNA-aptamers in solution using both experimental and theoretical methods. It could be very helpful in designing more effi cient aptamers based on results obtained from molecular simulations.
Optimalisasi Financial Teknologi (Fintech) terhadap Peningkatan Literasi dan Inklusi Keuangan Usaha Menengah Purwokerto
Authors: Mulasiwi Cut Misni , Julialevi Karina Odia
Published: June 2021

The purpose of this study is to explain the effect of fintech-based financial services on financial literacy and financial inclusion on Medium Enterprises in Purwokerto. To test the empirical model, Structural Equation Modeling (SEM) analysis was used. Other analysis tools used included AMOS 21.0, SPSS 16.0 and Microsoft Excel 2010. The number of samples in this study was 108 micro business owners. The results of this study indicate that fintech-based financial services have a positive influence on financial literacy and micro-business financial inclusion in Purwokerto.
ANALISA ORGANOLEPTIK DAN MIKROBIOLOGI AMDK DAN AMIU YANG DIJUAL SEKITAR KAMPUS UMKU
Authors: Rusidah Yunita , Farikhah Lailatul
Published: June 2021

This study is intended to find the quality of bottled drinking water (AMDK) and drinking water (AMIU) sold around University of Muhammadiyah Kudus, in terms of organoleptic and microbiological parameters in drinking water according to SNI 01-3554-2006 and PMK No. 492 of  2010. The test is carried out using 10 sample of drinking water. They are 7 sample of AMDK (Ades, Airmu, Aqua, Cleo, Crystalin, Le mineral and Vit) and 3 sample of AMIU (Pasuruhan, Prambatan and Purwosari depots). The research consists of organoleptic and  mikrobiologi (TPC, presence of E. coli and total coliform). The results of research shows that the organoleptik of all samples is in normal condition. Whereas, microbiologically, the TPC results before dilution were only Cleo and Ades which were suitable for consumption because they were absent from bacterial contamination. While the TPC results after dilution, testing the difference between E. Coli and Total coliform resulted in 7 samples of bottled drinking water which were safe and feasible as drinking water according to SNI 01-3553-2006 and 3 samples AMIU does not fulfil PMK No. 492/2010, as drinking water requirements.
High Fructose Consumption: More Pain Than Gain to Human Health
Authors: Isaiah Simon , Olanrewaju Oluwaseyi , Sholeye Abisola , Ayilara Modupe
Published: June 2021

An imbalance in any metabolic system can be traced to its homeostasis. When homeostatic environment is not attainable then there will be a response from the body. A new shift has emerged, “the negative feedback effect of high fructose consumption;” more pain than gain. The human metabolic system daily combat fructose sugar metabolism which emanates from high consumption. This inadvently lead to a chronological series of complications arising from the feedback. These feedbacks play pivotal roles in skeletal muscle damage and other body frameworks, it also fosters toxic advanced glycation end products (AGEs), factors that impose and inflict damaging effects to the body`s energy currency and serious threat to health. These damages are missed or overlooked because of early nonspecific physiological symptoms. High level of fructose has both long- and short-term effects on human metabolic processes. These effects which are majorly through the production of reactive oxygen species (ROS) and other free radicals, are felt in the disruption of biomolecules such as causing DNA mutation, lipid peroxidation etc. these effects in turn lead to various diseases such as cancer, diabetes, atherosclerosis, and other health issues. In this review, we will focus on the damaging effects this sugar has on human health and the present solutions being applied. We will also look at the next step in combatting and controlling these negative feedbacks.
What Membrane Capacitance?
Authors: Delalande Bernard , Tamagawa Hirohisa , Matveev Vladimir
Published: June 2021

The most common and taught membrane theory assumes that the membrane behaves as a kind of electrical capacitance that is exposed to an electrical current generated by an ionic flow. If this statement is verifiable, it can be confirmed by the laws of physics, mathematics and in particular electricity. We will demonstrate that this hypothesis is not verified and that it is necessary to modify biophysics according to already established and experimentally verified principles of physics.
High Mortality and Graft Loss After Infective Endocarditis in Kidney Transplant Recipients: A Case-Controlled Study From Two Centers
Authors: Tamzali Yanis , Danthu Clément , Aubry Alexandra , Faucher Jean-François , El Ouafi Zhour , Rufat Pierre , Essig Marie , Barrou Benoît , Touré Fatouma , Tourret Jerome
Published: June 2021

Purpose: Kidney Transplant Recipients (KTRs) tend to develop infections with characteristic epidemiology, presentation and outcome. While infective endocarditis (IE) is among such complications in KTRs, literature is scarce. We describe the presentation, epidemiology, and factors associated with IE in KTRs. Methods: We performed a retrospective case/control study which included patients from two centers. First episodes of definite or possible IE (Duke criteria), in adult KTRs from January 2007 to December 2018 were included, as well as two controls per case, and followed until December 31 2019. Clinical, biological, and microbiological data and the outcome were collected. Survival was studied using the Kaplan-Meier method. Finally, we searched for factors associated with the onset of IE in KTRs by the comparison of cases and controls. Results: Seventeen cases and 34 controls were included. IE was diagnosed after a mean delay of 78 months after KT, mostly on native valves of the left heart only. Pathogens of digestive origin were most frequently involved (six Enterococcus spp, three Streptococcus gallolyticus and one Escherichia coli), followed by Staphylococci (three cases of S. aureus and S. epidermidis each). Among the risk factors evaluated only age was significantly associated with the occurrence of IE in our study (63.8 years for cases vs. 55.6 years for controls, P=0.03) Patient and death-censored graft survival were greatly diminished five years after IE compared to controls being 50.3% vs. 80.6% (p<0.003) and 29.7% vs. 87.5% (p<0.002), respectively. Conclusion: IE in KTRs is a disease that carries significant risks both for the survival of the patient and the transplant.
Bending Analysis of Isotropic Rectangular Kirchhoff Plates Subjected to a Thermal Gradient Using the Fourier Transform Method
Authors: Fogang Valentin
Published: June 2021

The object of this paper is the bending analysis of isotropic rectangular Kirchhoff plates subjected to a thermal gradient (TG) using the Fourier transform method. The bottom and top surfaces of the plate are assumed to have different changes in temperature, whereas the change in temperature of the mid-surface is zero. According to classical plate theory, the governing equation of the plate contains second derivatives of the TG; these derivatives are zero by constant value of the TG, which leads to the absence of the TG in the governing equation. This paper presented an approach by which Fourier sine transform was utilized to describe the TG, while the double trigonometric series of Navier and the simple trigonometric series of Lévy were utilized to describe the deflection. Thus, the TG appeared in the governing equation, which simplified the analysis. Rectangular plates simply supported along all edges were analyzed, bending moments, twisting moments, and deflections being determined. In addition, rectangular plates simply supported along two opposite edges were analyzed, the other edges having various support conditions (free, simply supported, and fixed).
The Oxygen Transport Triad in High Altitude Pulmonary Edema: a Perspective from the High Andes
Authors: Zubieta-Calleja Gustavo , Zubieta-DeUrioste Natalia
Published: June 2021

Acute high altitude illnesses are of great concern for physicians and people traveling to high altitude. High Altitude Pulmonary Edema (HAPE) can be better understood through the Oxygen Transport Triad which involves the Pneumo-Dynamic Pump (Ventilation), the Hemo-Dynamic Pump (Heart and circulation), and Hemoglobin. The two pumps are the first physiologic response upon initial exposure to hypobaric hypoxia. Hemoglobin is the balancing energy-saving time-evolving equilibrating factor. The increased hemoglobin at high altitude reduces the percentage of dissolved oxygen in the arterial oxygen content with respect to sea level. At high altitude, the acid-base balance must be adequately interpreted using the high altitude Van-Slyke correction factors. Pulse-oximetry measurements during breath-holding at high altitude allow for the evaluation of high altitude diseases. The Tolerance to Hypoxia Formula shows that, paradoxically, the higher the altitude the more tolerance to hypoxia. All organisms adapt physiologically and optimally to a high-altitude environment to survive. Reduction of pulmonary hypertension in HAPE through oxygen administration results in a favorable outcome.
Strengths and Weaknesses of Semi-Structured Interviews in Qualitative Research: A Critical Essay
Authors: Kakilla Charles
Published: June 2021

A semi-structured interview (SSI) is one of the essential tools in conduction qualitative research. This essay draws upon the pros and cons of applying semi-structured interviews (SSI) in the qualitative research method. Moreover, the challenges of SSI during the coronavirus pandemic are critically discussed to provide plausible recommendations.
Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer
Authors: Huang Ching-Wen , Chen Yen-Cheng , Yin Tzu-Chieh , Chen Po-Jung , Chang Tsung-Kun , Su Wei-Chih , Ma Cheng-Jen , Li Ching-Chun , Tsai Hsiang-Lin , Wang Jaw-Yuan
Published: June 2021

This study investigated the roles of low-molecular-weight fucoidan (LMWF) in enhancing the anti-cancer effects of fluoropyrimidine-based chemotherapy. HCT116 and Caco-2 cells were treated with LMWF and 5-FU. Cell viability, cell cycle, apoptosis, and migration were analyzed in both cell types. Potential mechanisms underlying how LMWF enhances the anti-cancer effects of fluoropyrimidine-based chemotherapy were also explored. The cell viability of HCT116 and Caco-2 cells was significantly reduced after treatment with a LMWF-5-FU combination. In HCT116 cells, LMWF enhanced the suppressive effects of 5-FU on cell viability through the 1) induction of cell cycle arrest in the S phase and 2) late apoptosis mediated by the Jun-N-terminal kinase (JNK) signaling pathway. In Caco-2 cells, LMWF enhanced the suppressive effects of 5-FU on cell viability through both c-mesenchymal–epithelial transition (MET)/ Kirsten Rat Sarcoma virus (KRAS)/ extracellular signal-regulated kinase (ERK) and c-MET/ phosphatidyl-inositol 3-kinases (PI3K)/ protein kinase B (AKT) signaling pathways. Moreover, LMWF enhanced the suppressive effects of 5-FU on tumor cell migration through the c-MET/ matrix metalloproteinase (MMP)-2 signaling pathway in both HCT116 and Caco-2 cells. Our results demonstrated that LMWF is a potential complementary therapy for enhancing the efficacies of fluoropyrimidine-based chemotherapy in colorectal cancers (CRCs) with the wild-type or mutated KRAS gene through different mechanisms. However, in vivo studies and in clinical trials are required to validate the results of the present study.
Recent Progress Regarding the Evolution and Molecular Aspect of Insect Gall Formation
Authors: Guiget Antoine , Takeda Seiji , Hirano Tomoko , Issei Ohishima , Sato Masa H.
Published: June 2021

Galls are characteristic plant structures formed by hypertrophy (excessive increase in cell size) and/or hyperplasia (cell proliferation) induced by parasitic or pathogenic organisms. Insects are a major inducer of galls, and insect galls can occur on plant leaves, stems, floral buds, flowers, fruits, or roots. Many of these exhibit unique shapes, providing shelter and nutrients to the insects. To form unique gall structures, all-inducing insects are believed to secrete certain effector molecules and hijack host developmental programs. However, the molecular mechanisms of insect gall induction and development is still largely unknown because of the difficulty of studying non-model plants in the wild. Recent progress in next-generation sequencing has allowed us to determine the structure of biological processes in non-model organisms, including gall-inducing insects and their host plants. In this review, we first summarize the evolutionary aspects of gall-inducing life histories and their adaptive significance for insects and plants. Then, we briefly summarize recent progress regarding the molecular aspects of insect gall formation.
Application of Graph Theory Features towards EEG Data Classification Models for Working Memory and The Emotional States
Authors: Prakash Bhargav , Kumar Baboo Gautam , Baths Veeky
Published: June 2021

Functional Connectivity analysis using Electroencephalography signals is a common 2 practice. The EEG signals are converted to networks by transforming the signals into a correlation 3 matrix and analyzing the resulting networks. Here, four learning models, namely, Logistic Regres 4 sion, Random Forest, Support Vector Machine, and Recurrent Neural Networks, are implemented 5 on the correlation matrix data to classify them either on their psychometric assessment or the 6 effect of therapy. The classifications based on RNN provided higher accuracy( 74-88%) compared 7 to the other three models( 50-78%). The use of a correlation matrix, instead of using individual 8 graph features provides an initial test of the data. When compared with the time-resolved correlation 9 matrix it provided 4-5% higher accuracy.
COVID-19 and aspiration pneumonia: similar pulmonary findings with different diagnoses. A pitfall in [18F]FDG PET/CT.
Authors: Liberini Virginia , Grimaldi Serena , Huellner Martin W. , Giunta Francesca , Bachi Costanza , Dall’Armellina Sara , Onesti Federica , Ceci Francesco , Boccomini Carola , Icardi Massimiliano , Deandreis Désirée
Published: June 2021

Since December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a worldwide pandemic. Especially in the centers most affected by the pandemic, symptoms (such as fever, cough, myalgia, or fatigue) and/or radiological signs (such as ground-glass opacity) typically related to COVID-19 often diverted clinicians’ attention from other diseases. Despite the urgency to recognize and cure SARS-CoV-2 infection, a plethora of differential diagnoses must be considered, and other diseases must be equally and promptly treated, as described in this case report.
Mercury uptake by Paspalum distichum L. in relation to the mercury distribution pattern in rhizosphere soil
Authors: Xu Su , Gong Ping , Ding Wen , Wu Shengchun , Yu Xinwei , Liang Peng
Published: June 2021

Paspalum distichum L. was tested to evaluate their phytoremediation capacity for Hg contaminated soil through analyzing the dissipation of Hg in soil through a greenhouse study by using self-made rhizos box. Original soil samples were collected at Hg mining site with serious Hg contamination and a control site, respectively. Planting of P. distichum. L last for 60 days. Soil and plant samples were collected from four periods (0 d, 20 d, 40 d and 60 d) and soil samples were collected from five different rhizosphere distance in horizontal direction (0–2 cm, 2-4cm, 4-6cm, 6-8cm,8-10cm). The results showed that the presence of P. distichum. L significantly accelerated the Hg dissipation in soil compared with control. Hg concentration in the rhizospheric soil was affected by the plant growth period and the distance to the plant roots. The closer of soil to the root of P. distichum. L, the lower mercury concentration in soil. During the 60-day growing period, the concentrations of total Hg (THg) and methylmercury (MeHg) reduced by 45% and 64%, respectively, in the rhizosphere (0-2cm) of Hg contaminated soil. However, MeHg concentration was increased near the roots (0–4 cm) during the initial growing period (0–20 d), which may be attributed to the influence of root exudates. Root is the major part for Hg accumulation in P. distichum. L. The low ratio between Hg concentrations in underground and aboveground tissues indicated that it seemed difficult for Hg translocation from root to shoot. The highest THg (9.71 ± 3.09 µg·g− 1) and MeHg (26.97 ± 0.98 ng·g− 1) value in root of P. distichum. L were observed at the 20th day when P. distichum. L grown in Hg contaminated soil. The results of chemical fractions analyses showed that elemental Hg and residual Hg were the two major speciations followed by organic bound Hg in the Hg contaminated soil, which indicated the high bioavailability and ecological potential risk of Hg in Hg contaminated soil.
A Multiple-Bands Metamaterial Absorber Based in X, Ku and K-Band
Authors: Zafar Muhammad Fahim , Masud Usman
Published: June 2021

Developing a highly efficient and multiple-bands metamaterial absorber is a hot issue in recent era. In this paper, A multiple-bands metamaterial absorber has been presented which is based in X, Ku and K-band. Firstly, we have designed two single layer basic unit cell of X-shape and cross-shape, then they are arranged in the multi-layers structure form for the purpose of obtaining multiple- bands and wide band absorption. The proposed absorber is able to work in multiple bands because it has six peaks in the frequency range of 8–24 GHz with having near perfect absorption. Moreover, the sixth peak has a wideband absorption which is 2.93 GHz. Furthermore, the proposed absorber is also tested for polarization insensitivity and also for oblique incidence. Absorption was found polarization insensitive with almost perfect absorption.
Novel Superabsorbent Polymer Composites Based on α-Cellulose and Modified-Zeolite: Synthesis, Characterization, Water Absorbency and Water Retention Capacity
Authors: Fu Enfa , Zhang Sijia , Luan Yu , Zhang Yuting , Saghir Summaira , Xiao Zhanggang
Published: June 2021

Most superabsorbent polymers (SAP) are fully based on synthetic polymer (from petroleum resources) but costly, nondegradable, and environment-unfriendly. To overcome these disadvantages, biodegradable and renewable natural materials are suggested to be added into SAP. In this article, a new kind of SAP composites was synthesized by using AA, AM, α-cellulose, and modified-zeolite (MZE) as raw materials. The prepared novel SAP composite was analyzed by FTIR, XRD, SEM and TGA. Then, its water absorbency and water retention capacity were evaluated. The AA and AM were successfully grafted on α-cellulose chains and the introduction of MZE as an inorganic filler which is uniformly dispersed in the SAP composite matrix, both resulting in more undulant and coarser surface with abundant hydrophilic groups for novel SAP composites. By contrast with poly(AA-co-AM), the water absorbency of prepared novel SAP composites is increased by 93.88% in distilled water and 89.58% in 0.9 wt.% NaCl solution, respectively. Meanwhile, the retained water time of these SAP composites is 11.2 hs evaluated at 50 °C, increasing the water retention capacity by 71.79%. Moreover, both Tonset and Tpeak of prepared novel SAP composites are slightly increased compared with α-cellulose-poly(AA-co-AM), showing the introduction of MZE can slightly improve the thermal stability of novel SAP composites. The excellent water absorbency and retention capacity of novel SAP composites show it can be used as a water-keeping material for agricultural and horticulture applications.
Change Point Detection For Clustered Expression Data In Short Time Series.
Authors: Sieg Miriam , Sciesielski Lina Katrin , Kirschner Karin , Kruppa Jochen
Published: June 2021

Background: In longitudinal studies, observations are made over time. Hence, the single observations at each time point are dependent, making them a repeated measurement. In this work, we explore a different, counterintuitive setting: At each developmental time point, a lethal observation is performed on the pregnant or nursing mother. Therefore, the single time points are independent. Furthermore, the observation in the offspring at each time point is correlated with each other because each litter consists of several (genetically linked) littermates. In addition, the observed time series is short from a statistical perspective as animal ethics prevent killing more mother mice than absolutely necessary, and murine development is short anyway. We solve these challenges by using multiple contrast tests and visualizing the change point by the use of confidence intervals.Results: We used linear mixed models to model the variability of the mother. The estimates from the linear mixed model are then used in multiple contrast tests.There are a variety of contrasts and intuitively, we would use the Changepoint method. However, it does not deliver satisfying results. Interestingly, we found two other contrasts, both capable of answering different research questions in change point detection: i) Should a single point with change direction be found, or ii) Should the overall progression be determined? The Sequen contrast answers the first, the McDermott the second. Confidence intervals deliver effect estimates for the strength of the potential change point. Therefore, the scientist can define a biologically relevant limit of change depending on the research question.Conclusion: We present a solution with effect estimates for short independent time series with observations nested at a given time point. Multiple contrast tests produce confidence intervals, which allow determining the position of change points or to visualize the expression course over time. We suggest to use McDermott’s method to determine if there is an overall significant change within the time frame, while Sequen is better in determining specific change points. In addition, we offer a short formula for the estimation of the maximal length of the time series.
Trends In Frailty And Its Associated Factors In Community Dwelling Elderly Indian Population During COVID-19 Pandemic- A Prospective Analytical Study.
Authors: Gautam Karan , Krishnan Shyam , Kumar Vijaya , Nayak Megha
Published: June 2021

Background There is a scarcity of quality literature on the prevalence of frailty among community dwelling elderly in India. This study was originally planned to analyze the longitudinal trends in frailty status of community dwelling elderly in an Indian population as well to identify factors associated with frailty in the Indian context. However the recruitment phase of this study coincided with one of the largest lockdowns in history, associated with the COVID-19 Pandemic, and this gave us a unique opportunity to study the effects this pandemic enforced, absolutely necessary restrictions, had on the frailty status as well the factors affecting frailty in elderly.Methods A prospective observational study was designed and conducted amongst 19 community dwelling elderly of Dakshina Kannada District, in Karnataka India. Outcome variables of frailty(EPIF), Physical activity(PASE), functional mobility(TUG), gait speed(10 meter walk test), nutritional status(MNAT), body composition(BIA), and strength(dynamometry), were measured at baseline and on follow-up exactly after 3 months. The change occurring in these variables over the 3 month period was analyzed and the change in frailty was independently correlated with changes in each of the other outcomes.ResultsWe couldn’t identify any statistically significant difference in frailty over a period of 3 months. However there was a highly significant change in the physical activity status, lower extremity muscle strength, body composition, functional mobility, gait sped, and cognitive function in the same time period.Conclusion Though individual determinants of frailty in community dwelling changed over a 3 month period, these changes failed to produce any observable/measurable difference in frailty status.
The use of Early Warning System Scores in Pre-Hospital and Emergency Department Settings to Predict Clinical Deterioration: s Systematic Review and Meta-Analysis
Authors: Guan Gigi , Lee Crystal Man Ying , Begg Stephen , Crombie Angela , Mnatzaganian George
Published: June 2021

Background:
It is unclear which Early Warning System (EWS) score best predicts in-hospital deterioration when applied in the emergency department (ED) or pre-hospital setting.
Methods:
This systematic review and meta-analysis assessed the predictive abilities of five commonly used EWS scores: National Early Warning Score (NEWS) and its updated version NEWS2, Modified Early Warning Score (MEWS), Rapid Acute Physiological Score (RAPS) and Cardiac Arrest Risk Triage (CART). Outcomes of interest included admission to ICU, up-to-≥3-day and 30-day mortality. Pooled estimates were calculated using DerSimonian and Laird random-effects models, constructed by type of EWS score, cut-off points, outcomes, and study setting. Risk of bias was assessed using the Newcastle-Ottawa Scale. Meta-regressions investigated between study heterogeneity. Funnel plots tested for publication bias.
Results:
A total of 11,565 articles was identified, of which 15 were included. Eight and seven articles conducted in the ED and pre-hospital settings, respectively. In the ED, MEWS and NEWS at cut-off points of 3, 4, or 6 had similar pooled diagnostic odds ratios (DOR) to predict 30-day mortality, ranging from 4.05 (Confidence Interval (CI) 2.35–6.99) to 6.48 (95% CI 1.83–22.89), p = 0.757. The ability of MEWS (cut-off point ≥ 3) to predict ICU admission had a similar pooled DOR of 5.54 (95% CI 2.02–15.21). In the pre-hospital setting, EWS scores failed to predict 30-day mortality. Using high cut-off points of 5, 7, or 9, their predictability improved when assessing up-to-≥3-day mortality with DOR ranging from 11.60 (95%, CI 9.75–13.88) to 20.37 (95% CI 13.16–31.52).Publication bias was not detected. Participants’ age explained 92% of between-study variance.
Conclusion:
EWS scores’ predictability of clinical deterioration improves when applied on patient populations that are already in the ED or hospital. The high thresholds used and the scores’ failure to predict 30-day mortality make them less suited for use in the pre-hospital setting.