bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Developments in Medicinal Chemistry of Allosteric Activators of Human Glucokinase for Type 2 Diabetes Mellitus Therapeutics
Authors: Grewal Ajmer S. , Lather Viney , Charaya Neha , Sharma Neelam , Singh Sukhbir , Kairys Visvaldas
Published: April 2020

Background:

Glucokinase (GK), a cytoplasmic enzyme catalyzes the metabolism of glucose to glucose- 6-phosphate with the help of ATP and aids in the controlling of blood glucose levels within the normal range in humans. In pancreatic β-cells, it plays a chief role by controlling the glucose-stimulated secretion of insulin and in liver hepatocyte cells, it controls the metabolism of carbohydrates. GK acts as a promising drug target for the pharmacological treatment of patients with type 2 diabetes mellitus (T2DM) as it plays an important role in the control of carbohydrate metabolism.

Methods:

Data used for this review was based on the search from several science databases as well as various patent databases. The main data search terms used were allosteric GK activators, diabetes mellitus, type 2 diabetes, glucokinase, glucokinase activators and human glucokinase.

Results:

This article discusses an overview of T2DM, the biology of GK, the role of GK in T2DM, recent updates in the development of small molecule GK activators reported in recent literature, mechanism of action of GK activators and their clinical status.

Conclusion:

GK activators are the novel class of pharmacological agents that enhance the catalytic activity of GK enzyme and display their antihyperglycemic effects. Broad diversity of chemical entities including benzamide analogues, carboxamides, acrylamides, benzimidazoles, quinazolines, thiazoles, pyrimidines, pyridines, orotic acid amides, amino acid derivatives, amino phosphates and urea derivatives have been synthesized in past two decades as potent allosteric activators of GK. Presently, the pharmaceutical companies and researchers are focusing on the design and development of liver-selective GK activators for preventing the possible adverse effects associated with GK activators for the long-term treatment of T2DM.
Recent Advances in Liposomal Drug Delivery System of Quercetin for Cancer Targeting: A Mechanistic Approach
Authors: Das Sabya S. , Hussain Afzal , Verma Priya R. Prasad , Imam Syed S. , Altamimi Mohammad A. , Alshehri Sultan , Singh Sandeep Kumar
Published: April 2020

Quercetin (QT, 3,3′,4′,5,7-pentahydroxyflavone), is a natural flavonoid with nutritional value
and acts as a potential free-radical scavenger (antioxidant). QT has also been explored for its anti-cancer
as well as anti-proliferative activities against numerous cancerous cells. Moreover, QT exhibits significant
pro-apoptotic activity against tumor cells and is well established to control the growth of different
carcinoma cells at various phases of the cell cycle. Hence, it can reduce the burden of human solid cancer
and metastasis. Both these activities have been established in a diverse class of human cell lines in-vitro
as well as in animal models (in-vivo). Apart from the promising therapeutic activities of QT molecule,
their applications have been limited due to some major concerns, including low oral bioavailability
and poor aqueous solubility. Also, rapid gastrointestinal digestion of QT seems to be a key barrier for its
clinical translations for oral drug delivery in conventional dosage form. Henceforth, to overcome these
drawbacks, QT is loaded with liposomal systems, which exhibit promising outcomes in the upregulation
of QT by the epithelial system and also improved its targeting at the site of action. Furthermore,
Liposomes based Drug Delivery Systems (LDDS) have showed significant therapeutic activity with
conjugated drug moiety and exhibit safety, biocompatibility, biodegradability, and mitigated toxicity
despite having certain limitations associated with physiological and biological barriers. Herein, in this
review, we have focused on the mechanism related with the chemotherapeutic activity of QT and also
discussed the promising activity of QT-loaded LDDS as a potent chemotherapeutic agent for cancer
therapy.
Synthesis of Spiro1,4–Dihydropyridines: A Review
Authors: Sadri Zahra , Behbahani Farahnaz K.
Published: April 2020

The preparation of medicinally promising spiro1,4–dihydropyridines accompanied by their
applications in biological and pharmaceutical activities is presented. Spiro1,4–dihydropyridines were
synthesized using numerous reported methods including bronested acids such as p-TSA, AcOH, nano-ranged
calix[4]arene tetracarboxylic acid, sulfamic acid, PEG-OSO3H, tetramethylguanidinium triflate; lewis acids
including Zn(OTf)2, FeCl3, copper, alum, aluminosilicate nanoparticles, MnFe2O4 nanoparticles, manganese
ferrite nanoparticles, BF3OEt2; under alkaline conditions such as Et3N and piperidine; ionic liquids such as
[KAl(SO4)2·12H2O] and [Bmim]PF6, [MIM(CH2)4SO3H][HSO4]; and other miscellaneous procedures, for
example, microwave-assisted catalyst and solvent-free conditions, using iodine, PEG-400, and NaCl.
Preparation and Evaluation of Gliptin Liposomes for Targetting Ocular Region in Neurodegeneration
Authors: Sharma Deepika , Raj Swarna , Singhal Manmohan , Kumar Bhavna
Published: April 2020

Background:

Neurodegeneration shows the distressing effects of miscommunications
between brain cells. Insulin signaling dysregulation and small vessel disease in the base of diabetes
may be important contributing factors in Alzheimer’s disease and vascular dementia. Gliptins play
a role in neurodegeneration due to its neuroprotective effects. Eye is an extension of the brain.
Ocular route reduces drug’s adverse effects offering an advantage in minimizing risk by targeted
delivery to the brain. Conventional ophthalmic formulations exhibit poor bioavailability. Liposomes
serve as promising active carriers of drugs to posterior segment eye disorders due to improvement
in intravitreal half-life and targeted sustained drug delivery to the retina. Liposomes act
as drug carriers for entrapment of hydrophilic and hydrophobic drugs.

Objective:

The study aimed to formulate and evaluate sitagliptin liposomal formulation for sustained
effect in individuals suffering from neurodegeneration owing to high patient compliance,
especially in geriatric patients.

Methods:

Sitagliptin liposomes were prepared by the ethanol injection method and were evaluated
for various physicochemical properties such as visual appearance, particle size distribution, zeta
potential, % drug entrapment efficiency, % drug loading capacity and in vitro drug release studies.

Results:

The optimized formulation (L-3) showed round-shaped distinct particles with good stability.
The L-3 shows average diameter (281.9 nm); zeta potential (-11.9 mV); % entrapment efficiency
(82.7 ± 0.89%); % drug loading (33.11 ± 0.67%). L-3 followed Korsmeyer- Peppas model
with fickian diffusion transport of drug release giving n’ (0.3094), r2 (0.9753), with 83.78 ± 0.97%
of sustained drug release. The L-3 passes the sterility test indicating its safe use in ophthalmic purposes.

Conclusion:

Thus, liposomal drug delivery is a highly effective approach for sustained drug delivery
and minimizing the side effects of gliptins for effective therapy in neurodegeneration.
Support for working with the ALSA sound subsystem in a binary compiler of application level x86→«Elbrus»
Authors: Noskova E. S. , Rozhin A. F.
Published: April 2020

The success of a hardware platform is mainly determined by the software available for it. That is why the problem of enlarging the number of applications launched on the «Elbrus» platform is very acute. One of its possible solutions is the usage of binary compilation technology. The work of many modern applications is somehow related to sound processing. One of the most popular modern libraries for working with sound devices in Linux operating systems is the ALSA library. Its functionality is based on the set of ioctl system call commands. They were not supported in the x86→«Elbrus» binary compiler until recently. Therefore, occurred the issue of implementing support for ALSA-ioctl commands in binary compiler. In order to solve this problem, it was necessary to study the Linux kernel implementation of this technology. The gained knowledge was used to develop proprietary tools for the binary compiler making it possible to use the ALSA in applications translated under the «Elbrus» architecture.
Estimation of the probabilistic characteristics of the majority method for processing short segments of a pseudo-random sequence
Authors: Podoltsev V. V.
Published: April 2020

Simulation modeling of the processing method for pseudo-random sequence (PRS) short segments based on the majority tests gives the probability characteristics that are different from the results of a calculation using the Gaussian approximation. The simulation modeling shows that the probability of bit error decoding is changed discretely with the explicit minima and maxima for the length of the processed segment of the PRS. This is due to the fact that the decoder always uses a fixed test sequence, which is determined by the initial phase of the analyzer. Thus, the distribution of these checks determines the dependence of the bit error probability. On this basis, the paper conducts a theoretical study of the probability characteristics synchronization method based on the majority tests, taking into account the specifics of the PRS analyzer. The article formulates and solves the task of analyzing probabilistic characteristics of the majority method of processing short segments of the PRS, which required finding the probability of bit error of decoding. The analytical relations for the probability of bit error of decoding are obtained. The calculations and systematic analysis of the results are performed. It is shown that: with the increase in the length of the processed segment or the length of the valid section N the probability of error can be greater than the probability of destructive errors; the method based on the majority tests with a high probability of destructive errors has a significant advantage in the average code search time over the Ward’s method. Based on the obtained results a modification of the method that will provide the optimal choice of the length of the processed segment of PRS N will be offered in further studies.
WALKABILITY FACTORS FOR A CAMPUS STREET
Authors: Harun Nor Zalina , Nashar Amanina , Bachok Syahriah
Published: April 2020

It has been reported that translating walkability is complicated, particularly the execution of its theory in planning practices. This study untangled the queries by presenting factors that makes campus interesting, walkable, and more importantly to be characterised as ‘pedestrian friendly campus’. For this purpose, campus street walkability factors were analysed using factor analysis to find out the most significant measures of street walkability in the campus and its underlying items. All data has been run through SPSS beforehand and have met the assumption required for factor analysis that were formulated with the sample size of 500 respondents. The result from the study reveals that walkability factors of the campus were gratified from four significant factors that are classified as comfort, connectivity, safety and accessibility. The study reveals that proper streetscape design uncovers various potentials of the streets in forming part of a successful campus open space in the future. Moreover, the empirical findings in this research have provided a new understanding of the street function. Aside from functioning as space connectors, the streets offer broader opportunities for various pedestrian activities, which consists of passive and active activities that would contribute to the students’ social and physical enhancement.
LAND USE CHANGES IN RURAL TOWN: A CASE STUDY OF KUALA NERANG, KEDAH
Authors: Othman Abdul Ghapar , Jizan Nurul Hanisah
Published: April 2020

Urbanization is the process of transforming a characteristically rural society into an urban one. The urban population is growing at an increasing rate while the rural population is declining, giving rise to imbalances in the development between urban and rural areas. The government’s strategy is to distribute the development to the major settlement centres in the rural areas, which are experiencing the same effects of urbanization as the urban areas in terms of changes to the use of land, especially the reduction of agricultural land and the increase in built-up areas. This study used the method of overlay in GIS applications to investigate land use changes, the speed of urban expansion and direction of development that has taken place from the period 2001 to 2018 in the town of Kuala Nerang, Kedah. This town has undergone a change in its status from a main settlement centre to a district administrative centre. Agricultural lands, which were targeted for development in the rural areas, have been converted into built-up areas. The speed of urban expansion has been slow, although some areas have recorded a higher rate. The development is moving towards the west along the main road connecting the major towns in this part of the state. The functions of the district administrative centre have influenced land use changes.
Participación, empoderamiento, identidad y creatividad en tres buenas prácticas de arte
Authors: Serra Sangüesa Laia , Alonso Martínez Héctor , Paczkowski María , Aragay Borràs Josep María
Published: April 2020

Objetivos. Reflexionar sobre tres buenas prácticas donde el arte, la educación y la acción social están especialmente presentes: Riborquestra, Basket Beat y Espacio Mestizo. El objetivo principal es formular un discurso reflexivo que ayude a construir una mirada transferible del proceso artístico comunitario de estas propuestas.Metodología. La metodología utilizada es el Estudio de Caso. Analizando tres casos paradigmáticos donde el uso del arte resulta significante, siguiendo técnicas cualitativas, se incorpora la voz de sus creadores para analizarlas desde las cuatro dimensiones relevantes: participación, empoderamiento, identidad y creatividad.Resultados. Se presentan las descripciones de cada una de dichas prácticas artísticas, sus orígenes, su contexto, sus objetivos específicos con respecto al arte y a la acción socioeducativa, implementación, alcance de usuarios a los que atiende. Además, se presenta transversalmente el análisis reflexivo, a partir de estudiarlas desde las dimensiones: participación, empoderamiento, identidad y creatividad para su comprensión y transferencia en el entorno social.Conclusiones. El paradigma cualitativo en el cual están inmersas devela las enormes posibilidades discursivas que cada una de ellas puede generar en torno al arte, el arte comunitario (AC) y el desarrollo cultural comunitario (DCC). Las dimensiones empoderamiento, participación, creatividad y construcción de identidad, no solamente indican aspectos que les unen, sino que hacen evidente un discurso particular dentro de la similar horizontalidad de cada autodefinición específica. Lo interesante de investigar y reflexionar sobre arte, a partir de prácticas educativas y artísticas reales, brinda la posibilidad de sugerir, además, puntos de anclaje donde encontrar diferentes pistas susceptibles para la transferencia en el medio social educacional. Pistas que podrían resultar relevantes para su proyección en diferentes contextos educacionales, participativos y culturales.
O serviço social face às potencialidades e ambiguidades da política social contemporânea: Contributos para a reflexão sobre o contexto português e brasileiro
Authors: Pinto Albuquerque Cristina Maria , Brito Arcoverde Ana Cristina
Published: April 2020

Na presente comunicação pretendemos evidenciar as potencialidades e paradoxos subjacentes às políticas sociais atuais, emergentes em contextos de aumento da exclusão e de austeridade do Estado Social, bem como os respetivos impactos nas práticas e orientações do Serviço Social português e brasileiro. Para tal, começaremos por referenciar criticamente os grandes princípios da nova geração de políticas sociais, com enfoque nas chamadas políticas de ativação, em Portugal e no Brasil, para, de seguida, refletirmos sobre as readaptações da intervenção social delas decorrentes e os possíveis efeitos que tais readaptações poderão comportar. De hecho, el proceso de reconfiguración de las políticas sociales ha dado lugar, en Portugal y en Brasil –dos países con profundas desigualdades estructurales y los estados de bienestar limitados y tardíos– a una acción pública en el contexto de las políticas sociales, y más personalizadora y activa; una acción (o inacción) que exige nuevas capacidades de los trabajadores sociales. Na verdade, o processo de reconfiguração das políticas sociais tem dado origem, quer em Portugal, quer no Brasil - dois países com desigualdades estruturais profundas e Estados-Providência limitados e tardios - a uma ação pública, no âmbito das políticas sociais, mais personalizante e ativadora; uma ação (ou inação) que apela a novas competências dos profissionais sociais. Deste modo, como argumentaremos, a dimensão teleológica do Serviço Social começa a transformar-se. Cada vez mais o objetivo dos profissionais do social, em determinados contextos, é estar presente para gerir, em permanência, a não integração. Assim, o acompanhamento social pode tornar-se uma sucessão, ininterrupta, de pequenos passos; no limite, uma estratégia de aceitação e de contenção do que existe ou uma forma de psicologização das desigualdades sociais, analisadas doravante sob o ângulo das experiências singulares de desprezo social. Se assim for a intervenção social reduz-se a um papel paliativo e em muitos casos neopaternalista, logo, neutralizador de uma lógica de cidadania social, historicamente conquistada.
Actitudes hacia personas en situación de calle en hombres y mujeres del norte de México
Authors: Partida-Bautista Valeria , Esquer-Soto Lucila-Alejandra , Barrera-Hernández Laura-Fernanda
Published: April 2020

Objetivo: El objetivo de esta investigación fue medir las actitudes hacia las personas en situación de calle, y comparar los puntajes de hombres y mujeres de una ciudad al norte de México. Método: La investigación es un estudio descriptivo-comparativo de corte transversal. Participaron 100 personas con edades entre 18 y 66 años con una media de 23.27 años (DE=6.66). Resultados: Entre los resultados destaca que las personas poseen una actitud neutral hacia las personas en situación de calle, los ítems con los que las personas estuvieron más de acuerdo, consistieron en que las personas en situación de calle se aprovechan de su condición para pedir dinero, no quieren trabajar, y que las personas compran dulces que venden los indigentes. Por otra parte, en la comparación de sexos se observaron diferencias significativas, donde las mujeres presentaron actitudes más positivas que los hombres. Conclusiones: Los hallazgos coinciden con los resultados de otras investigaciones que señalan actitudes neutrales o encontradas respecto a las personas en situación de calle.
Pobreza en la producción de conocimiento y la formación Profesional del Trabajo Social en Brasil
Authors: Da-silva Eliana-Andrade
Published: April 2020

Objetivo. El presente artículo tiene la intención de problematizar el debate sobre la categoría pobreza en la producción de conocimiento y en la formación profesional del Trabajador Social. Método. Este artículo fue elaborado a partir de una investigación documentaria y bibliográfica. Resultados. Los resultados apuntan al predominio de abordajes teóricos sobre la categoría pobreza en el ámbito de Trabajo Social a partir de un prisma de totalidad, en el cual las relaciones vigentes de la sociedad desencadenan un proceso de desigualdades sociales donde conviven contradictoriamente abundancia y miseria. En este sentido, la investigación indica la existencia de algunos consensos y disensos entre los autores con respecto a la necesidad de insertar en la formación profesional del Trabajador Social el análisis sobre los orígenes y expresiones del fenómeno pobreza. Conclusiones. Se concluye que, aunque haya en el ámbito de formación profesional el predominio de concepciones de pobreza afiliadas a la tradición marxista, coexisten concepciones de pobreza vinculadas a las matrices teórico-metodológicas oponentes, las cuales traen críticas a la perspectiva crítico-dialéctica. Así, se configura un cuadro analítico marcado por polémicas y embates teórico metodológicas relevantes, resultando en la producción de nuevos estudios e investigaciones en el área de Trabajo Social.
Reacción Patriarcal contra los Avances en Materia de Violencia Machista
Authors: Canet-Benavent Encarna , Martínez-Martínez Lucia
Published: April 2020

La violencia que se ejerce contra las mujeres es una violación de los derechos humanos muy extendida, y, en gran parte, impune en todo el mundo. Cuando parecía que existía un consenso en el abordaje de la violencia machista, actualmente nos enfrentamos a una amenaza de retroceso, que intenta poner en cuestión, incluso, el concepto acordado por Naciones Unidas (1979), OMS (2002), el Convenio de Estambul (2011) y la Ley Orgánica 1/2004, de 28 de diciembre, de Medidas de Protección Integral contra la violencia de género en el caso del Estado español. Este artículo es una reflexión, basada en la idea de que las sociedades democráticas tenemos la obligación de blindar la defensa de los derechos de las mujeres, y enfrentar las mentiras de las ideologías negacionistas de la violencia de género de la extrema derecha, que campan impunemente por el mundo. Consideramos que —atacando las medidas contra la violencia de género y los avances de los movimientos feministas— nos están agrediendo a más de la mitad de la población mundial. Y eso es violencia machista y destrucción de los derechos humanos. Por tanto, el Feminismo es la mejor herramienta para luchar contra los retrocesos que pretende imponer la extrema derecha.
Desigualdad en los Derechos Humanos de las mujeres mayores: caso estado de Zacatecas
Authors: Bañuelos-García Víctor-Hugo , García-Martínez Flor-de-María , Hernández-Ponce José-Rogelio
Published: April 2020

De acuerdo con la Organización Mundial de la Salud (OMS), 2015, entre 2000 y 2050, a nivel mundial, la población de adultos mayores de 60 años pasará del 11% al 22%. En México, de acuerdo con el Consejo Nacional de Población (CONAPO), 2019, alcanzará cerca de 34%. Referente al Estado de Zacatecas, México, se estima que irá del 11.08% en 2015 al 14.5% en 2030. Este fenómeno significará un problema social que implica pobreza, discapacidad, abandono y enfermedades, entre otras condiciones, que, de no considerarse, se verán violentados los Derechos Humanos de sus habitantes. El objetivo del presente estudio consistió en evaluar y determinar la desigualdad de los Derechos Humanos que viven las mujeres mayores, en el Estado de Zacatecas, México, para lo cual se utilizó un cuestionario aplicado a 2.566 personas. Se hizo un análisis factorial exploratorio, en el que se encontraron tres factores: el primero de ellos denominado apoyo familiar, el segundo abuso físico y psicológico, el tercero, dependencia física y servicios. Además, mediante la Chi Cuadrada de Pearson, se encontraron relaciones estadísticamente significativas entre ser mujer y desigualdad económica, laboral y discapacidad. Por tanto, se concluye que, en el caso del Estado de Zacatecas, existe una transgresión de los Derechos Humanos de la Mujeres Mayores.
Diversity analysis of Rhacophorus margaritifer (Schlegel, 1837) in Baturraden based on RAPD markers
Authors: Sulistyahadi Fajar Nur , Puspitasari I Gusti Agung Ayu Ratna , Nuryanto Agus
Published: April 2020

Rhacophorus margaritifer is an endemic species of arboreal frog in Java. Previous studies found this frog in several locations of Baturraden, namely in primary forest of Ketenger area, along Pancuran Pitu tourism track, and Baturraden Botanical Garden. There were still limited studies of molecular diversity of R. margaritifer and no prior data from population in the southern slope of Mount Slamet. This study aimed to look at the genetic polymorphism and determine the locus diversity of R.margaritifer population in Baturraden by using the PCR-RAPD technique.  Frog tissue samples were taken from three populations in Kalipagu hiking trail (HPK 01), Baturraden hiking trail (HPK 02), and Baturraden Botanical Garden (KRB). DNA was extracted using the Chelex method. Molecular characterization was performed based on RAPD markers. The RAPD marker band pattern was changed to binary data 0-1 and analysed using Arlequin software ver.3.5. A total of 19 frog individuals were obtained during sampling at three locations. High genetic diversity had been observed in all populations with gene diversity range from 0.9643 in HPK 01 population to 1.0000 in both KRB and HPK 02 populations. A high locus variation was also observed for all populations with values of 0.159524 in KRB; 0.165816 in HPK 01; 0.192857 in HPK 02, respectively. AMOVA indicated no genetic difference among populations of R. margaritifer (p=0.50244).
Understanding Immigration Today: The Importance of Religious Literacy on Immigration and Refugee Crisis
Authors: Mendoza Cristian J.
Published: April 2020

This paper deals with the concept of immigrants and refugees when defining public policy. Public understanding of immigrants and refugees comes from political definitions and from secular and faith-based organizations. Most political definitions regarding immigrants and refugees are found in public policies: opening or closing borders, visa regulations, etc. These definitions include concepts regarding people who are object of the legislation under the mindset of people writing it. Sometimes the legislators don’t understand the world vision of immigrants and refugees. And those who respect the law don’t always know the mindset and motivations of the legislators. So a sort of common literacy is needed. This literacy is an essential part of this study. The objective of this paper is twofold. First, it aims to identify some of the general areas lacking research to adequately address the Refugee Crisis. Second, it aims to look forward for future research with representatives of key international entities helping immigrants and refugees. Its contents are organized in three parts: outlining the basic understanding of immigrants and refugees as it is found in contemporary academic literature, showing that without common concepts it is hard to reach agreements for social collaboration. making a call to action.
The Copyrightability of Tattoos: A Practical Examination of Law Cases
Authors: Gourgoulianni Sofia
Published: April 2020

In the recent years, tattoo has become a trend and, as each subject which becomes a mass product, it has begun concerning areas of science. One of the major areas it is being linked to, is law science and more precisely intellectual property rights. It concerns intellectual property because each tattoo design can be considered as an original work of art protected by law. The major concern of law protection arises from the fact that the tattoos are depicted in other cases for commercial reasons. In this paper we will examine the basic legal dispute as to whether the tattoos can be considered as works of art and as to whether the intellectual property rules can be applied in their case.
FACEBOOK AS LOGISTIC SUPPORT TO LINGUISTIC INTERACTION
Authors: Pavlović Dragana , Momčilović Nikoleta , Petrović Dina
Published: April 2020

New technologies provide significant logistical support to contemporary learning process, particularly in the field of university education. Students, as part of the youth population in the process of education, use new media technologies daily, among which an important place belongs to Facebook. Although Facebook is not characterised as a technology through which one learns, and is primarily used for communication and exchange of information, a number of research point to the importance of Facebook as a logistic support to the learning process. The main objective of the research was to determine students' attitudes about the use of Facebook in learning and sharing information important to learn the German language in the process of university studying. The study included 120 students of Faculty of Philosophy, who learn German as a second foreign language. Data obtained from the research confirmed that students use Facebook to share information related to exams, to exchange translation and other specialised texts in German. As for study purposes, the results of the research show that students mostly use Facebook for information sharing in the field of experience exchange with older colleagues, and least for the exchange of scientific articles. Research findings indicate that more than half of the surveyed students recognised Facebook as a significant support in learning the German language. As a recommendation, the need for greater use of new media for learning and for providing adequate logistics of the learning process stands out, which is particularly important in the current reform of higher education.
Chemical composition of rainwater collected from 2006 to 2009 in Mexico City and at a rural site at Morelos State, south central Mexico
Authors: García-Martínez Rocío , Carrillo-Chavez Alejandro , Torres-Jardón Ricardo , Ramirez-Guzmán Alejandro , López-Carrasco Moisés
Published: April 2020

The objective of the study was to evaluate the chemical composition of rainwater in urban and suburban areas of central Mexico to identify the possible sources of rainwater contamination. The rainwater was collected at Universidad Nacional Autónoma de Mexico, Campus Ciudad Universitaria (CU), in the southern part of Mexico City at 2200 meters above sea level (m a.s.l.). CU has many green areas with high to moderate traffic densities where air quality presents serious problems of pollution by particulate matter. The other sampling site is a forested rural area (Tlalnepantla), State of Morelos, Mexico, a suburban area 86 km to the south of Mexico City. A total of 145 rainwater samples were collected in the rain period from 2006 to 2009. The ions analyzed were the following: SO42-, NO3-, Cl-, HCO3-, Na+, K+, Ca2+, Mg2+, NH4+ and H+. Ammonium was the most abundant cation in both sites and is one of those responsible for the neutralization of acidic compounds in the atmosphere. The relative abundance of the inorganic anions present in the rainwater was in the following order: SO42- > NO3- > Cl-, for the alkaline metals the order was Ca2+ >Mg2+ > Na+ > K+ and Ca2+ >Mg2+ >K+ >Na+ for CU and Morelos, respectively. A correlation analysis shows a strong positive correlation among the ions, indicating that the most important source was anthropogenic. Air mass back trajectories were associated with the SO42-, Ca2+, Mg2+, NH4+ and H+ concentrations observed on each rainy day. Four factors were used in the statistic analysis and was weighted within each factor. Weights greater than 0.5 are considered to be significant components of each factor. The four factors explain 84.7 % of the total variance of all of the data for CU and 66.9 % for Morelos. All of these factors were associated with all of the analyzed ions. Air pollutant back trajectories were used to understand atmospheric transport and to identify the origins and pathways of air masses influencing the concentrations of the measured ions in rainwater.
Imprints of historical pollution and the 218-60 BCE tsunamigenic period in southwestern Spain
Authors: González-Regalado María Luz , Monge Guadalupe , Carretero María Isabel , Pozo Manuel , Rodríguez-Vidal Joaquín , Cáceres Luis Miguel , Abad Manuel , Campos Juan Manuel , Bermejo Javier , Tosquella Josep , Izquierdo Tatiana , Prudêncio Maria Isabel , Dias Maria Isabel , Marques Rosa , Gómez Paula , Toscano Antonio , Romero Verónica , Ruiz Francisco
Published: April 2020

The Doñana National Park is a Biosphere Reserve located within the estuary of the Guadalquivir River (SW Spain). It is mainly composed of extensive fluvio-tidal marshes partially protected by an elongated sandy spit. Three phases have been distinguished in the late Holocene evolution of this spit based on textural, geochemical, palaeontological and, chronological data recorded in a long core (31 m). Phase 1 (890 BCE-218 BCE) is characterized by the alternation of lagoonal silty sediments and slightly polluted marsh deposits, the latter with contamination from thousand-year-old mining. Phase 2 (218 BCE-90 CE) is characterized by several historical tsunamis, which caused the erosion of previous dune systems and the deposit of these sandy sediments on the adjacent bottom of the lagoon. Phase 3 (90 CE-Present) includes a regressive sequence (lagoonal bottom-marsh-dune system), with the pollution of lagoonal sediments due to Roman mining activities.
Enseñar química en un mundo complejo.
Authors: Ramos Mejía Aurora De los Ángeles
Published: April 2020

Para adecuarnos al panorama que presenta un mundo complejo y de incertidumbre, la enseñanza de la química debe contemplar su ejercicio desde la complejidad, centrándose en que el estudiante aprenda a resolver problemas químicos en contextos relevantes y complejos. Así, también debe utilizar la evaluación para desarrollar habilidades de pensamiento de orden superior, sobre todo, para fortalecer el tejido de una sociedad civil.
A NEW NON-ECLIPSING CV SDSSJ 122405.58+184102.7 - A PROBABLE MEMBER TO THE SW SEXTANTIS TYPE STARS
Authors: Avilés A. , Arias I. , Chávez C. E. , Pérez J. E. , Tamayo F. J. , Pérez-Tijerina E. G. , Aceves H.
Published: April 2020

We present observational evidence that helps classify the non-eclipsing binary system SDSSJ 122405.58+184102.7 as a new member of the SW Sextantis (SW Sex) class. First, from the analysis of the optical light curve, we identify the presence of two periodic signals that develop on different time scales. The first one is the orbital period of 0.167811(1) days (= 4.027464 (3) h) and the second one is the white dwarf spin period of 28.6 minutes. This second period is probably the first evidence for the presence of a magnetic white dwarf in the system. The second evidence is the presence of the HeII λ4886 emission line in its optical spectrum. In this work we interpret the detected periodicities within the context of a magnetic accretion model for SW Sex stars.
Proactive personality and innovative behavior: A moderated mediation model
Authors: Su Fangguo , Zhang Jin
Published: April 2020

A 2 time-point survey was used to examine the mediating mechanism and boundary conditions through which proactive personality affects graduate students' innovative behavior. Results revealed that a proactive personality positively affected the innovative behavior of the students; feedback
seeking mediated the influence of proactive personality on innovative behavior, and academic self-efficacy moderated the relationship between proactive personality and innovative behavior through feedback seeking. Namely, when graduate students' academic self-efficacy is high, for those with
a proactive personality there is a stronger positive influence on their innovative behavior through feedback seeking. When graduate students' academic self-efficacy is low, a proactive personality has a weaker positive impact on their innovative behavior through feedback seeking. In this study
we have, therefore, established a new mediating mechanism and boundary conditions through which proactive personality influences innovative behavior and have expanded existing innovation theory. Finally, we proposed management recommendations for ways to enhance and increase graduate students'
innovative behavior.
Effect of persuasion via social media on attitude toward elite sport policies
Authors: Lin Yi-Hsiu , Chen Chen-Yueh
Published: April 2020

We examined the effect of different persuasion interventions in social media (central route vs. peripheral route vs. no persuasion) on attitude toward elite sport policies. We conducted 2 experimental studies with a college student sample (Study I) and a sample drawn from the general
public (nonstudent sample, Study II). Results indicated that in the student sample, attitude of the peripheral-route-persuasion group toward elite sport policies was significantly more positive than that of either the no-persuasion group or the central-route-persuasion group. However, results
from the nonstudent sample suggested that both the central-route-persuasion and peripheral-route-persuasion groups had more positive attitude toward elite sport policies than did the nopersuasion group. Involvement did not moderate the persuasion–attitude relationship in either the student
or nonstudent sample. The findings from this research indicate that a more concise way of communication (peripheral route) is more effective for persuading college students. Government agents may adopt the findings from this research to customize persuasion interventions to influence their
target audience effectively.
Linking perceived organizational support for strengths use to task performance
Authors: Ding He , Yu Enhai , Li Yanbin
Published: April 2020

We investigated the mediating effects of positive affect and strengths use in the relationship between perceived organizational support for strengths use (POSSU) and employees' task performance. Data were gathered at 2 time points, separated by a 2-week interval, from 157 employees
working in various Chinese enterprises. We applied structural equation modeling and PROCESS macro analysis to the data. The results indicate that POSSU was positively related to task performance and that this relationship was mediated by strengths use. In addition, positive affect and strengths
use played a sequential mediating role in the relationship between POSSU and task performance. However, positive affect was not a significant mediator in the POSSU–task performance relationship. Theoretical and managerial implications are discussed in the context of the literature on
POSSU and task performance.
Experimental prototype for visual support in the calibration of the precision indicator lights of approach slope, for a landing track using a drone
Authors: Herrera Rubio Jorge Enrique , Parra Prada Sergio Andrés
Published: April 2020

The use of calibration methods for visual aids systems in airports guarantees aviation safety with new alternatives and precision methods. The article shows the implementation of an experimental prototype for the support of visual aid in the calibration of precision indicator lights by means of a drone to improve the approach slopes of aircraft. In each of the experimental tests the following activities were developed: a) execute the program that contains the code to perform the process of emulation / calibration of the lights, b) connect the model of the lights to the Arduino and be connected to the portable equipment, c) perform the drone calibration process each time a flight plan is made, d) connect the mobile device to the drone’s remote control to integrate them into the wireless network (Wi-Fi), e) on the device mobile the application is executed to configure the flight plan and f) the emulation / calibration is performed with the model of the lights. Obtain the best visibility angles according to the effective percentages of experimentation that indicate the accuracy of the experimental system proposed through a mobile application. In addition, this article proposes a methodology for the calibration of the Precision Approach Path Indicator (PAPI) lights through wireless devices. The proposed methodology establishes the basic conditions for the development of the process of supervision, monitoring and calibration of the PAPI lighting system of any track in Colombia according to the regulations on luminous visual aids.
Liquid balance - steam for methanol mixing - Benzen using the Peng Robinson and Van-Laar models
Authors: Palencia Muñoz Miguel Fernando , Prieto-Jiménez Natalia , González Silva Germán
Published: April 2020

This paper is related to the procedure for calculating curves dew point and bubble point of a binary system, consisting of the methanol and benzene mixture to 45°C, using the Peng-Robinson cubic equation to calculate the fugacity coefficient of gas i in the mixture, and Van Laar model to calculate the activity coefficient of component i in the liquid mixture. Then a comparison between the theoretical data with the experimental data and later with the commercial simulator Hysys-Aspen, which applies the model of Wilson. The simulation was validated with experimental data,in addition to comparing the results with a commercial simulator.
Diversity of Kikuyu grass (Cenchrus clandestinus): A review
Authors: Arango Gaviria Juliana , Echeverri Zuluaga Julián , López Herrera Albeiro
Published: April 2020

Kikuyo is a perennial plant of rapid growth and high aggressiveness, which represents one of the most important resources for the development of the economy and for the support of specialized livestock in Colombia. It was introduced in the mid-30s, where it has spread thanks to its invasive nature; however, of the studies that have been carried out, few have focused on the genetic diversity and phenotypic variability within their populations, as well as the possible contributions that these can provide to sustainability in the agricultural sector. The objective of this revision is to explore previous information about some basic topics of this forage species and mainly about its diversity and genetic variability in different latitudes. A systematic search was made of scientific articles, indexed journals, books and documents that had as main axis information about basic grass topics and mainly about genetic variability and diversity. In other countries, several lines of Kikuyo grass have been registered, as well as some studies on genetic diversity that have been able to determine, in different populations, a large amount of genetic variation consistent with the wide morphological variability of pasture.
El mentefacto conceptual como estrategia de lectura en octavo grado
Authors: Monsalve Flórez Jhon Alexánder
Published: April 2020

Este artículo de reflexión presenta los resultados de una intervención didáctica consistente en la orientación del uso de mentefactos conceptuales como estrategia de lectura, mediante el modelo de Pedagogía Dialogante desarrollado por Julián de Zubiría Samper, con el fin de comprender las facilidades y dificultades de esta estrategia en una muestra de estudiantes de bachillerato. Para ello, se propone, a partir de una investigación-acción, una secuencia didáctica estructurada en cinco momentos, transversalizada por textos argumentativos alusivos a la Masacre de las Bananeras: 1) Prueba diagnóstica, centrada en presaberes en torno a la organización de mentefactos; 2) Orientación de reconocimiento macroproposicional, enfocado especialmente en la redacción de oraciones isoordinadas; 3) Mediación para la identificación de proposiciones excluyentes, a partir de las ideologías que se contraponen en los discursos argumentativos abordados en clase; 4) Comprensión de las supraordinaciones e ifraordinaciones en los textos y elaboración de diagramas mentefactuales; y 5) Evaluación por parte de los estudiantes sobre las dificultades y comprensiones durante el uso de esta estrategia. Luego de la intervención, se hace necesario replantear el camino para la identificación de proposiciones excluyentes que constituyen uno de los procesos más importantes en la elaboración de mentefactos
Dominio afectivo de los estudiantes de educación media hacia las matemáticas
Authors: Duarte Sepúlveda Lizeth Camila , Ricardo Quiñones Nataly , Santos López Laura Vanessa
Published: April 2020

Las matemáticas son fundamentales en el currículo escolar, siendo una materia obligatoria para todos los niveles educativos, que contribuye al desarrollo del pensamiento lógico y el pensamiento matemático de los estudiantes. Por esa razón, se plantea relacionar el dominio afectivo que tienen los estudiantes de educación media hacia las matemáticas con el rendimiento académico en el área. Para ello, primero se determina las creencias de los estudiantes de educación media hacía las matemáticas. Seguido de, describir las emociones que poseen los estudiantes de educación media hacia las matemáticas. Para finalmente, identificar las actitudes que presentan los estudiantes de educación media hacia las matemáticas. El trabajo se realiza en un tiempo de seis meses, en la Institución Educativa Misael Pastrana Borrero de Cúcuta, Norte de Santander. La investigación es de tipo correlativa. La población para desarrollar el proyecto se tuvo en cuenta los estudiantes del Colegio Misael Pastrana Borrero pertenecientes a la sede central, el cual ofrece el servicio educativo de sexto a undécimo grado en jornada única y está conformada por 800 estudiantes. En esta investigación la muestra será tomada por conveniencia, puesto que no se realiza un muestreo probabilístico sino, que será aplicada a todos los estudiantes de décimo y undécimo grado de la sede central Misael Pastrana Borrero. Se recolecta información a partir de un cuestionario sometido a juicio de expertos y adaptado al contexto para tal fin. Los datos son procesados a través de herramientas de Microsoft office y el programa SPSS. La información obtenida establece que el dominio afectivo que poseen los estudiantes hacia las matemáticas es positivo y su desempeño académico fue bueno, además se encuentra que existe una posible relación en algunos aspectos del dominio afectivo con el rendimiento académico de los estudiantes.
Gobernanza y participación para el desarrollo de estudiantes como sujetos políticos
Authors: Mendoza Montañez Edwin Fabian , Rumierk Bravo Juanita , Rincon Gallardo Maria Laura , Martinez Contreras Zuleyma
Published: April 2020

El presente texto se abordará en torno al ejercicio de la gobernanza y su uso como herramienta para el desarrollo de estudiantes como sujetos políticos, en donde se analizará de qué manera la participación contribuye al desarrollo de la gobernanza en los estudiantes, tomando parte de los diferentes postulados teóricos que permiten su abordaje, avanzando en la comprensión de esta en el contexto educativo colombiano, reconociendo la importancia de la escuela como formadora de competencias ciudadanas en los estudiantes y su participación política; en efecto, se realizó por medio del enfoque cualitativo, con nivel explicativo dado a que se busca responder a la causa de un fenómeno social empleando el método fenomenológico, pues este permite analizar el sujeto de estudio a partir de la realidad que este vive, tanto interna como externamente, pues dicha realidad radica su esencia en el modo como el sujeto vive y percibe el fenómeno; finalmente se comprenderá que el modelo de la gobernanza resulta importante para la formación política participativa en estudiantes desde la escuela, siendo está el primer contexto educativo en donde se forman las ideologías y subjetividades que regirán a las personas a lo largo de su vida.
Uso del video como estrategia pedagógica para el desarrollo de la competencia escritora en estudiantes de educación básica
Authors: Ortega González Irma María , Rincón Álvarez Gerson Adriano , Hernández Suárez César Augusto
Published: April 2020

El proyecto busca utilizar el video como una herramienta que potencie los procesos relacionados con las competencias escritora, a través del uso y estudio del contenido audiovisual en los estudiantes de educación básica en una institución educativa pública de la Ciudad de Cúcuta, Colombia. Se desarrolla bajo el enfoque cuantitativa y se enmarcó bajo un diseño cuasiexperimental con pretest - postest para un grupo experimental y un grupo control. Se realiza un diagnóstico (pretest) sobre las dificultades que presentan los estudiantes a nivel escritural; Posteriormente, se diseña y aplica la estrategia didáctica la cual consta de 4 intervenciones donde de forma progresiva se desarrollaron actividades escriturales apoyadas con videos; finalizada la implementación de la propuesta, se realiza el postest fundado en una rúbrica para evaluar las “características principales de la composición”. Como resultado se puede evidenciar que existen diferencias significativas en todas las características de la composición, lo que permite concluir que estas causan la mejora en la competencia escritora con la intermediación pedagógica del video y en orden de influencia se encuentra contenido, uso del lenguaje, organización, vocabulario gramático, y por último ortografía.