bluuebunny/crossref_metadata_2025 huggingface dataset:
КОНЦЕПТУАЛІЗАЦІЯ ЕКОНОМІЧНОЇ ПОЛІТИКИ ПІДТРИМКИ ІНВЕСТИЦІЙНО-ІННОВАЦІЙНОГО РОЗВИТКУ ПІДПРИЄМНИЦТВА
Authors: Гринів В. Б.
Published: April 2024

Статтю присвячено актуальному питанню визначення тенденцій розвитку інноваційного підприємництва в інноваційній екосистемі. Розглянуто інструменти економічної політики України військового часу, зокрема дієвість державних програм релокації бізнесу, розміщення держзамовлень на продукцію військового чи подвійного призначення, а також ухвалені рішення щодо дерегуляції бізнесу. Виявлено, що підприємництво потребує інституційної підтримки, яку запропоновано орієнтувати на забезпечення трансформаційної мети інноваційного розвитку економіки, спрямовуючи інновації у соціально-економічне відродження. Визначено інституціональні межі втручання держави у процеси інвестиційно-інноваційної активності підприємництва, зокрема лібералізацію підприємництва, активізацію міждержавної взаємодії, прискорення діджиталізації та створення інноваційних ринків. Запропоновано формування цілей впливу обґрунтовувати результатами загальної динаміки інвестиційно-інноваційної активності підприємництва, оскільки цільова функція інвестиційної діяльності реалізується за рахунок зміцнення конкурентних позицій та зниження вразливості до несприятливих фінансових факторів. Це дозволить активізувати інвестиційні процеси в економіці для поєднання процесів післявоєнного відновлення зі структурною трансформацією галузей за рахунок розвитку наукомісткого виробництва. Інвестиційними цілями є модернізація управління економічними процесами і розвиток галузей, здатних функціонувати в умовах глобального конкурентного середовища у поєднанні з розробкою інструментів протидії наявним викликам і загрозам, заходи регулювання пропонується індикативно оцінювати з позиції результативності. Запропонована концептуальна схема економічної політики стимулювання інвестиційно-інноваційної активності підприємництва гнучко поєднує адміністративні та економічні важелі регулювання. Завдання ефективного відновлення української економіки потребує вирішення довгострокових структурних проблем, що зумовлює необхідність подальших розвідок у сфері інноваційно-інвестиційної підтримки розвитку вітчизняного підприємництва.
СТАНОВЛЕННЯ ІСНУЮЧОЇ МОДЕЛІ РИНКУ ЕЛЕКТРИЧНОЇ ЕНЕРГІЇ В УКРАЇНІ
Authors: Шашков С. В.
Published: April 2024

Всі процеси, пов’язані з купівлею та продажем електричної енергії в Україні, регулюються вимогами та правилами функціонуючого в даній сфері ринку. В статті досліджено основні моделі існуючих ринків електричної енергії: модель вертикально інтегрованого ринку, трьохетапну модель Єдиного покупця, модель із дерегульованою оптовою торгівлею електричною енергією та як їх еволюції модель із дерегульованою оптовою та роздрібною торгівлею. Досліджено етапи становлення вітчизняного ринку електричної енергії за період із 1991 по 2019 рік, узагальнено та відображено основні події, мету та результати, кінцевим із яких був поетапний перехід до моделі ринку двосторонніх договорів та балансуючого ринку. Розглянуто недоліки, які зумовили до переходу від моделі Єдиного покупця, а також причини, які стали передумовою для переходу до існуючої моделі. Окрему увагу приділено ряду документів, що було розроблено, ухвалено та затверджено з метою впровадження конкурентних механізмів функціонування ринку електричної енергії, а також його інтеграції до нормативів ЄС, і як кінцеву мету розглянуто організацію роботи нової моделі ринку електричної енергії. Визначено ряд принципово нових складових та сегментів впровадженої в 2019 році моделі ринку електричної енергії, зокрема: за двосторонніми договорами, “на добу наперед”, внутрішньодобовий та балансуючий ринки. Окрему увагу в статті приділено комплексу існуючих проблемних питань, які на сьогоднішній день мають місце під час функціонування існуючої моделі ринку електричної енергії та є перешкодою для подальшого успішного розвитку вітчизняної електроенергетики, зокрема: обмежена конкуренція, коливання в сегменті ринку “на добу наперед”; перехресне субсидіювання; перекладання тарифів; недостатня фінансова спроможність учасників ринку, недостатність системного моніторингу та ін. Визначено необхідність проведення подальших досліджень у напрямку розробки дієвих організаційно-економічних механізмів функціонування всіх сегментів ринку електричної енергії.
IMPACT OF PREGNANT MARE SERUM GONADOTROPIN (PMSG)INJECTION ON SOME HISTOLOGICAL AND PHYSIOLOGICALPROPERTIES OF AGED JAPANESE QUAIL OVARIES AND TESTES.
Authors: الصالحي خالد جلاب كريدي
Published: April 2024

The present study was conducted at Agriculture and Experimental Research station- Agriculture College - Basrah University to investigate the effect of PMSG administration on some histological and physiological traits of aged Japanese quail (Coturnix japonica). Seventy- two, 10 months old birds of Japanese quail were divided into 3 treatment groups with 2 replicates (6 females and 6 males in each replicate). birds of 1st group were injected once with 100 IU while 2nd group were given 50 IU /bird and 3rd group was considered as control (without injection) , Results revealed that 1st and 2nd groups had a significant (p< 0.05) improvement in histological and physiological characteristics of both ovaries and testes . Ovarian weights of treated groups were significantly (p<0.05) higher than those of 3rd group, while no such differences were exist between relative weight of testes of studied groups. From the present study, it can be concluded that PMSG hormone injection (in both treated groups), improved the histological and physiological characteristics of Japanese quail ovaries and testes.
Chemical Content and Antibacterial Activity of Some Extracts of Anastatica hierochuntica leaves
Authors: AL-Saeed Arwa
Published: April 2024

The present study was undertaken to study the chemical content and antibacterial activity of Anastatica hierochuntica leaves by preparation extracts (n-hexan, ethanolic 70% and aqueous) and tested against Grampositive bacteria (Streptococcus pyogens and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Proteus vulgaris). The results of chemical analysis showed that hexan extract contains phenols , terpenes and sterols only, while extracts (ethanolic 70% and aqueous) contain carbohydrates , phenols , flavonoids , tannins , saponins and alkaloids also observed contained this plant on minerals (Cu, Zn and Fe ) in concentrations (8.65±0.30, 47.51±1.31, 169.48±7.11) ppm respectively.The antibacterial activity of the preparation extracts was evaluated using agar well-diffusion method, the results indicated that plant extracts were more active against Gram-negative bacteria than Gram-positive  bacteria, alcoholic extract has antibacterial activity stronger than hexan and aqueous extracts. From this results we concluded that Anastatica hierochuntica leaves can used in treatment of various disorders by havea number of active components and antibacterial activity.
Anti-inflammatory and antibacterial activities of Lippia nodiflora and its effect on blood clotting time
Authors: Al-Snafi Ali Esmail
Published: April 2024

Aqueous extract of Lippia nodiflora possessed anti-inflammatory activity in Carrageenan induced mice paw edema in both doses 100 and 200 mg /kg bw (P< 0.01). However, the ethanolic extracts didn’t induced anti-inflammatory effects in both doses. Aqueous extract of Lippia nodiflora exerted a concentration – dependent antibacterial activity against E.coli but not effective against Staphylococcus aureus and Pseudomonas aeruginosa. Ethanolic extract possessed antibacterial activity against gram positive (Staphylococcus aureus) and gram negative (E. coli) but not effective against Pseudomonas aeruginosa. Ethanolic extract of Lippia nodiflora significantly hasten blood clotting when used in a dose of 100 mg/kg (P< 0.05) and 200 mg /kg (P< 0.01). The effect of the ethanolic extract appeared dose dependent. However, aqueous extract didn’t exerted significant effects on blood clotting time in both doses used in this sTUDY
Highly active antiretroviral therapy and sexual risk behavior: a meta-analytic review
Authors: Crepaz Nicole , Hart Trevor , Marks Gary
Published: April 2024

[para. 1]: “Highly Active Antiretroviral Therapy (HAART) became available in the United States and other developed countriesin1996. Although HAART regimens may not be effective for all infected persons due to drug-resistant strains of human immune deficiency virus (HIV) and unmanageable adverse effects, many HIV-positive persons receiving HAART have substantially lowered their HIV RNA levels (ie, viral load) through strict adherence to treatment regimens. Consequently, the incidence of AIDS and deaths due to AIDS have decreased considerably in countries in which HAART has been widely available.”
Cognitive-Behavioral Erectile Dysfunction Treatment for Gay Men
Authors: Hart Trevor , Schwartz Danielle R.
Published: April 2024

  

The purpose of the present paper is to assist cognitive-behavioral therapists who are treating erectile dysfunction among gay men. Little information is available to cognitive-behavioral therapists about the psychological and social effects of erectile dysfunction in this population, or how to incorporate the concerns of gay men with erectile dysfunction into a case conceptualization and treatment plan. The present paper provides an overview of the extant research on erectile dysfunction and of its treatment among gay men. The application of clinical research on erectile dysfunction to treatment for gay men will be illustrated using two case examples.
Need for improved access to HIV prevention programmes
Authors: Hart Trevor
Published: April 2024

HIV prevalence continues to grow worldwide. The United Nations Programme on AIDS (UNAIDS) estimates that there are 33.4 million people living with HIV, a total that is more than 20 per cent higher than in 2000. India accounts for half of Asia’s HIV prevalence, with approximately 2,270,000 persons living with HIV in India in 2008. Like many Asian countries, India has a concentrated epidemic, in which three high risk groups, female sex workers (FSWs), men who have sex with men (MSM), and injection drug users (IDUs) have HIV prevalences that are 10 - 20 times more than the prevalence found among women presenting at antenatal clinics. Migrant workers and truckers are also viewed at higher risk, as potential bridge populations between these high risk groups and the general population.
The Impact of Stressful Life Events on Unprotected Anal Intercourse Among Gay and Bisexual Men
Authors: M. Calzavara Liviana , Burchell Ann N. , Lebovic Gerald , Myers Ted , S. Remis Robert , Raboud Janet , Corey Paul , Swantee Carol , Hart Trevor
Published: April 2024

We investigated the hypothesis that gay and bisexual men experiencing stressful life events are more likely to engage in risky sexual behavior. Data were from a cohort study of 155 HIV-positive and 207 HIV-negative men in Ontario, Canada (1998-2007). We quantified the relation between stressful life events and unprotected anal intercourse with a non-regular partner. In the past 6 months, 19% reported unprotected intercourse (HIV+: 28%; HIV-: 13%) and 58% reported one or more stressful life events (HIV+: 64%; HIV-: 55%). Among HIV-negative men, the odds of unprotected intercourse increased by 1.15 for each additional event (95%CI 1.06, 1.24). Among HIV-positive men, those who reported the event "problems due to alcohol or drugs" were 1.80 (95%CI 1.27, 2.56) times more likely to report unprotected intercourse. Interventions to assist men to cope with stress may help to prevent population spread of HIV and improve overall health.
Protective and risk factors associated with stigma in a population of older adults living with HIV in Ontario, Canada
Authors: Emlet Charles A , Brennan David J. , Brennenstuhl Sarah , Rueda Sergio , Hart Trevor , B. Rourke Sean , The OHTN Cohort Study Research Team
Published: April 2024

Although the deleterious effects of HIV stigma are well documented, less is known about how various types of stigma impact older adults living with HIV disease and what factors exacerbate or lessen the effects of HIV stigma. Using cross-sectional data from the OHTN cohort study (OCS), we undertook multiple linear regression to determine the predictors of overall HIV stigma, and enacted, anticipated, and internalized stigma subscales in a sample of OCS participants age 50 and over (n = 378). Being female, heterosexual, engaging in maladaptive coping, and having poor self-rated health were associated with greater overall stigma while being older, having greater mastery, increased emotional-informational social support, and a longer time since HIV diagnosis were associated with lower levels of stigma. The final model accounted for 31% of the variance in overall stigma. Differences in these findings by subscale and implications for practice are discussed.
Substance Use, Violence, and Antiretroviral Adherence: A Latent Class Analysis of Women Living with HIV in Canada
Authors: Hart Trevor , Carter Allison , Roth Eric Abella , Ding Erin , Milloy M-J , Kestler Mary , Jabbari Shahab , Webster Kath , de Pokomandy Alexandra , R. Loutfy Mona , Kaida Angela , Team CHIWOS Research
Published: April 2024

We used latent class analysis to identify substance use patterns for 1363 women living with HIV in Canada and assessed associations with socio-economic marginalization, violence, and sub-optimal adherence to combination antiretroviral therapy (cART). A six-class model was identified consisting of: abstainers (26.3%), Tobacco Users (8.81%), Alcohol Users (31.9%), 'Socially Acceptable' Poly-substance Users (13.9%), Illicit Poly-substance Users (9.81%) and Illicit Poly-substance Users of All Types (9.27%). Multinomial logistic regression showed that women experiencing recent violence had significantly higher odds of membership in all substance use latent classes, relative to Abstainers, while those reporting sub-optimal cART adherence had higher odds of being members of the poly-substance use classes only. Factors significantly associated with Illicit Poly-substance Users of All Types were sexual minority status, lower income, and lower resiliency. Findings underline a need for increased social and structural supports for women who use substances to support them in leading safe and healthy lives with HIV.
Interplay of abiotic, biotic, and individual factors in shaping individual growth and demography in a high-elevation common toad population
Authors: Lenzi Omar , Grossenbacher Kurt , Zumbach Silvia , Lüscher Beatrice , Althaus Sarah , Thoma Marco , Schmocker Daniela , Recher Helmut , Ozgul Arpat , Schmidt Benedikt
Published: April 2024

1. Vital rates of individuals in natural populations, such as survival and breeding probabilities, can be affected by abiotic (i.e. environmental conditions), biotic (e.g. population density), and individual factors (i.e. individual traits). Many studies often consider the direct effects of one or two of these sources of vital-rate variations, but taking them all into account might reveal important relationships, including indirect trait-mediated effects. 2. We estimated survival and breeding probability in a high-elevation population of an ectotherm species while accounting for the effects of these three types of factors: abiotic (in the form of the length of the active season and temperature at emergence from hibernation), biotic (population size), and individual factors (body size). We expect this population living at the extreme range of the species’ distribution to be affected mainly by abiotic factors, given the harsh environmental conditions experienced. 3. Using 28 years of capture-mark-recapture data and individual body size measurements on an alpine population of the common toad (Bufo bufo), we estimated male survival probability with a Bayesian Cormack-Jolly-Seber model, female survival and female breeding probability with a Bayesian multistate model, and we estimated sex-specific growth curves. 4. Our findings reveal significant negative impacts of all three factor types on survival. Moreover, breeding probability exhibited a Markovian pattern, notably breeding biennially, with temperature at hibernation emergence, an abiotic factor, affecting the probability of skipping a breeding season, and population density, a biotic factor, influencing the resuming of breeding. We also found indication for the presence of indirect effects, with both abiotic and biotic factors potentially affecting asymptotic growth, and thus by extension, survival through changes in body size. 5. Our study reveals interesting and novel results for a population in a context seldom studied. It also highlights the complexity of factors affecting vital rates directly and indirectly, as well as the importance of long-term studies, especially in understudied habitats and taxa.
EXPLORING THE MILLENNIALS PREFERENCES IN MOISTURIZER PRODUCT USING MIX METHOD APPROACH
Authors: Jannah Hannifah Miftakhul , Hakim Muhammad Saiful , Hakim Nabila Silmina
Published: April 2024

In recent years, we have witnessed the growing interest from millennials to preserve their skin health. In order to maintain their skin health, they consume a variety of skincare products. One of the essential products for them is moisturizer product. This research objective is to explore the critical moisturizer product features for customer purchase decision. This research employs mixed method that consists of descriptive study and interview to millennials. The result of descriptive study indicates that price of the product is important cue for quality, therefore, consumer is preferring to select product with middle range prices. Descriptive analysis also reveals that consumer has weighted their decision based on the product composition and product efficacy. In addition, the analysis shows that consumer prefer small size product so it will be more practical to keep in carry on container. The interview gives us detailed information regarding the purchase decision process. The analysis of interview uncovers that beauty vlogger with honest review is more credible for purchase behavior compared with well-known brand ambassadors.
THE DEVELOPMENT OF ENTREPRENEURIAL INTENTION AMONG STUDENTS
Authors: Ilhami Susanti Dwi , Rikah Damayanti Rumaji
Published: April 2024

The research has been purposed to describe the correlation of entrepreneurial self-efficacy and also entrepreneurial education on entrepreneurial intention by mediating the entrepreneurial mindset of students from Universitas YPPI Rembang. Students who have overtaken the Entrepreneurial Skills course become respondents to the research. A saturated sampling approach was taken in the study using 83 respondents. Data collection was obtained by distributing questionnaires. The PLS-SEM analysis method is used by researchers in answering the proposed hypothesis. The research results showed that the entrepreneurial mindset could not act as a mediating variable on the correlation of entrepreneurial self-efficacy and also entrepreneurial education on entrepreneurial intention. The findings have implications for Universitas YPPI Rembang to increase entrepreneurship education activities which are more varied so that students are more interested in building a business. Preparing a more up-to-date entrepreneurship curriculum and guest lectures by inviting more practitioners so that the business tips provided can spur the entrepreneurial intention of Universitas YPPI Rembang students.
THE ROLE OF THE INDEPENDENT LEARNING PROGRAM ON CAMPUS IN SHAPING THE ENTREPRENEURIAL ECOSYSTEM IN UNIVERSITIES
Authors: Prabawanti Benedicta Evienia , Tarigan Thia Margaretha
Published: April 2024

In 2020, the Indonesian minister of education, Nadiem Makarim, launched the MBKM (Merdeka Learn Campus Merdeka) program to prepare higher education graduates who are demanding to face change. Through the MBKM Program, students have the opportunity for one semester or the equivalent of twenty credits to study outside the study program at the same University and a maximum of two semesters or the equivalent of forty credits of studying in the same study program at different universities, looking in various study programs at multiple universities, and learning outside the university. To give birth to prospective entrepreneurs, universities must create a conducive entrepreneurial ecosystem for students (Mack & Mayer, 2016). The role of each component in the ecosystem, such as faculty, according to Hayter (2016), is needed in adding to the social network of prospective entrepreneurs. Autio et al. (2014) revealed that policymakers are a more dominant factor in creating an entrepreneurial ecosystem. Mueller and Toutain (2015) explain that schools are the right environment to foster cultural creativity, self-confidence, and development freedom. Various internal and external elements must be involved in forming an entrepreneurial ecosystem in higher education. This research is an early stage of research to identify multiple inputs owned by universities in shaping their entrepreneurial ecosystem through the MBKM Entrepreneurship program. The method used in this study is a qualitative method using a participatory action research (PAR) approach. The research results are expected to help universities map the factors that can support the formation of an entrepreneurial ecosystem through the MBKM program carried out by universities.
THE URGENCY OF STANDARDIZING THE OPEN APPLICATION PROGRAMMING INTERFACE IN IMPLEMENTATION OF OPEN BANKING FOR CUSTOMER PROTECTION
Authors: Sakti Muthia , Utami Kery , Sulastri
Published: April 2024

Open banking with Open Application Programming Interface (open API) technology is an initiative aimed at streamlining the payment system in Indonesia. The open API allows banks to integrate their systems with digital financial service providers (fintech) and bold trade (e-commerce) providers by disclosing customer transaction data. This study investigates the urgency of open API standardization in implementing open banking in Indonesia. This study uses a normative juridical approach to secondary data. The data includes primary, secondary, and tertiary legal materials. In addition, it also uses qualitative normative data analysis methods. It was concluded that before the National Open API Payment Standard (SNAP) stipulation, the process of sharing data between banks and fintech and/or e-commerce still needed to be standardized but was only based on an agreement between the parties. Banking in Indonesia has various open API standards that can affect the protection of customer data. According to the Financial Services Authority Regulation Number 12/POJK.03/2018, the relationship between banks, fintech, and/or e-commerce in providing digital banking services based on agreements between parties needs to be stronger. OJK is indeed present as a supervisory agency. However, the parties will eventually come back to a deal between themselves. Unlike the Regulations of the Financial Services Authority, the Regulations of the Members of the Board of Governors, which form the legal basis for SNAP, provide standards that must be complied with by both service providers and service users. However, implementing SNAP-based open APIs still requires personal data protection regulations.
FROM THE ELIMINATION OF SEXUAL VIOLENCE DRAFT BILL TO THE SEXUAL VIOLENCE CRIME : CONFLICT OF IDEOLOGY FEMINIST AND RELIGIOUS IDEOLOGY RELATED TO SEXUAL CONSENT
Authors: Ulul albab Wildan , Evasolina Lubis  , Brian Khukuh Wijaya  , I Nyoman Gian Erlangga  , Khairiah Aziz  , Salisa
Published: April 2024

The Sexual Violence Crime Law (UU TPKS) was passed in 2022. However, the TPKS Law cannot be separated from various incidents, this is also the background for the TPKS Law taking a long time to be ratified. One of the controversial ones is related to the sexual consent paradigm which is often the reason for rejection of the TPKS Bill. This research uses the library study method, namely the author collects data by searching for data and information through books, journals, documents, articles, news and other library sources. The author will collect library data, record and analyze discourse related to sexual consent in the TPKS Bill, both within the DPR and external parties, namely community organizations. The Prosperous Justice Party (PKS), Islamic Defenders Front (FPI) and several other organizations use religious ideology in rejecting the TPKS Bill, while KUPI, Komnas Perempuan, Gusdurian, and other women's activist groups try to remember the mindset of the initial purpose of the TPKS Bill which was formed in basically departs from feminist ideology.
JUDICIAL ANALYSIS OF PROVIDING LEGAL ASSISTANCE TO THE POOR IN REALIZING ACCESS TO JUSTICE
Authors: Zulfa Majida Andi , Sururi  , Itmam Aulia Rakhman
Published: April 2024

This study focuses on the implementation of free legal services for individuals by the Legal Aid Office (LBS) and the Ministry of Justice, in accordance with Law No. 16 of 2011 on Legal Aid. According to Article 1 paragraph 3 of the Law, the Legal Aid Office is a legal entity or a community organization that provides legal services. The aim of this study is to understand the function and role of the Human Rights Commission as law enforcement officers and to comprehend issues related to the implementation of legal services. The research method employed in this study is normative legal research, utilizing primary and secondary legal sources. Material analysis in this research involves committee work that systematically categorizes legal materials to facilitate the analysis of the research work. The study reveals that the primary authority for legal services lies with LBS/Orkemas, which is authorized to verify and accredit the Human Rights Commission as a legal service provider. Furthermore, the study emphasizes the importance of understanding the function and role of the Human Rights Commission as law enforcement officers and underscores their crucial involvement in the implementation of legal services. The research also highlights that the main authority for legal services is vested in LBS/Orkemas, which has been verified and accredited by the Human Rights Commission as a legal service provider.
Menggali Disiplin Diri Lewat Praktikum Kimia Pengalaman Laboratorium yang Membentuk Sikap Positif
Authors: Ikha Islahul Hasanah  , Frisila Apriliana Putri  , Erya Kamajaya Sang Adil Suryo Illahi Joyodilogo  , Raina Zhafira Ruliandi  , Rheiza Setiawan Putra Pratama  , Muhammad Hanif Firmansyah  , Mochamad Whilky Rizkyanfi
Published: April 2024

Praktikum kimia merupakan praktikum yang penting untuk berbagai aspek kehidupan. praktikum kimia tidak hanya digunakan untuk kepentingan laboratorium atau akademik saja, namun hasilnya bisa digunakan untuk kehidupan sehari-hari. Dalam praktikum kimia dibutuhkan ketelitian yang sangat tinggi karena satu faktor kesalahan saja dapat membuat seluruh praktikum kimia gagal. Dibutuhkan ketelitian dan kedisiplinan dalam praktikum kimia agar seluruh praktikum kimia berjalan dengan lancar dan didapatkan hasil yang maksimal. Kedisiplinan dalam praktikum kimia ini sejalan dengan fokus penelitian ini adalah untuk mengobservasi tingkat kedisiplinan setiap orang yang merupakan siswa SMK dan mahasiswa dengan jurusan yang berfokus pada kimia. Penelitian ini menggunakan metode pendekatan kualitatif dengan jenis penelitian deskriptif kuantitatif. Penelitian ini menyasar kepada responden yang merupakan siswa SMK dan mahasiswa dengan jurusan yang berfokus di kimia. Disajikan beberapa pertanyaan mengenai kedisiplinan dalam praktikum kimia untuk responden dan hampir semua responden menjawab bahwa para responden melakukan praktikum dengan baik dan disiplin.
THE APPLICATION OF TORT LAW IN ADDRESSING ISSUES IN HALAL PHARMACEUTICAL PRODUCTS: SAFEGUARDING CONSUMER RIGHTS
Authors: Naimat Nasihah , Ahmad Mustafa Mimi Sofiah , Hilmy Nasrijal Nasreen Miza , Mahat Ida Rahayu
Published: April 2024

The demand for Halal pharmaceutical products in Malaysia has been on the rise, but this positive trend is accompanied by concerning issues such as the use of fake Halal logos and the inclusion of non-Halal ingredients in pharmaceutical products, which present risks to consumers and undermine trust in the industry. Accordingly, tort law emerges as one of the legal mechanisms for consumers seeking redress in cases involving fake Halal logos and non-Halal ingredients. With the application of a doctrinal method based on qualitative legal research methodology, this article analyses the remedies under tort law. The study investigates the effectiveness of remedies provided by tort law in dealing with these issues. Findings reveal that the existing remedies under tort law do not entirely safeguard consumers’ apprehensions related to fake Halal logos and non-Halal ingredients. Therefore, there is a need for a comprehensive review of existing laws to ensure that they provide complete protection for consumers and help to promote the continuous growth of the Halal pharmaceutical industry in Malaysia.
The library information resources of the Scientific Library of Yanka Kupala State University of Grodno
Authors: Misyukevich S. M.
Published: April 2024

The author examines the experience of Yanka Kupala State University Library (Grodno, Belarus) in providing digital document resources to its users. The proprietary information resources are reviewed; the selection principles for library Internet-resources are specified; user awareness services are described. The library organizes information educational workshops intended for the faculty, though it experiences some problems in disseminating information on library services and resources, in particular, students’ low interest in information literacy and lacking teaching hours for library courses. The author suggests several possible solutions and prospective vectors for the academic library, i. e. development of proprietary resources, corporate collaboration, improvement, development and introduction of new methods of user services. The author emphasizes the importance of improving librarians’ professional competences in providing reliable and enhanced information.
New strategy for the development of the digital integrated system of the National Library of the Republic of Sakha (Yakutia)
Authors: Maksimova S. V.
Published: April 2024

The author analyzes the processes of modernization of digital resources of the National Library of the Republic of Sakha (Yakutia). She also substantiates the need for integrated systems for data multi-purpose parallel use. The partners of expanding cataloging objects are the Ministry of Culture and Spiritual Development of the Republic of Sakha (Yakutia), Republican House of Folk Art and Socio- Cultural Technologies – in building the Electronic Catalog of Intangible Cultural Heritage “Cultural Code of Yakutia”; and the Academy of Sciences of the Republic of Sakha (Yakutia) – in acquiring the Electronic Encyclopedia and the National Database “Science of Yakutia”. The national database “Science of Yakutia“ is discussed in great detail; it comprises scientific works, findings of fundamental and applied scientific research submitted on the basis of an agreement between the author (researcher) / scientific organization and the library. The author discusses the experience of acquiring the database based on authors’ territorial affiliation – regardless the content and place of publishing; publications by indigenous Yakutian authors; publications by Yakutian residents; authors related to Yakutia professionally. The author also reviews the issues of database modernization, application of scientometric technologies in information support of regional science and education, and the projected new information platform OPENScienceSakha (repository) comprising bibliographic information on scientific publications and citation of publications based on the methodology of polythematic international databases of scientific citation
Reviews by A. I. Zemskov and V. A. Tsvetkova of the textbook by V. N. Gureev and N. A. Mazov “Information resources and tools for researchers” [Informatsionniye resursy i instrumenty v rabote issledovatelya] (Moscow : INFRA-M, 2024. 191 p. doi: 10.12737/1989238. ISBN 978-5-16-018378-7 (Print); ISBN 978-5-16-111400-1 (Online))
Authors: Zemskov A. I. , Tsvetkova V. A.
Published: April 2024

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Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Authors: Bray Freddie , Laversanne Mathieu , Sung Hyuna , Ferlay Jacques , Siegel Rebecca L. , Soerjomataram Isabelle , Jemal Ahmedin
Published: April 2024

This article presents global cancer statistics by world region for the year 2022 based on updated estimates from the International Agency for Research on Cancer (IARC). There were close to 20 million new cases of cancer in the year 2022 (including nonmelanoma skin cancers [NMSCs]) alongside 9.7 million deaths from cancer (including NMSC). The estimates suggest that approximately one in five men or women develop cancer in a lifetime, whereas around one in nine men and one in 12 women die from it. Lung cancer was the most frequently diagnosed cancer in 2022, responsible for almost 2.5 million new cases, or one in eight cancers worldwide (12.4% of all cancers globally), followed by cancers of the female breast (11.6%), colorectum (9.6%), prostate (7.3%), and stomach (4.9%). Lung cancer was also the leading cause of cancer death, with an estimated 1.8 million deaths (18.7%), followed by colorectal (9.3%), liver (7.8%), female breast (6.9%), and stomach (6.8%) cancers. Breast cancer and lung cancer were the most frequent cancers in women and men, respectively (both cases and deaths). Incidence rates (including NMSC) varied from four‐fold to five‐fold across world regions, from over 500 in Australia/New Zealand (507.9 per 100,000) to under 100 in Western Africa (97.1 per 100,000) among men, and from over 400 in Australia/New Zealand (410.5 per 100,000) to close to 100 in South‐Central Asia (103.3 per 100,000) among women. The authors examine the geographic variability across 20 world regions for the 10 leading cancer types, discussing recent trends, the underlying determinants, and the prospects for global cancer prevention and control. With demographics‐based predictions indicating that the number of new cases of cancer will reach 35 million by 2050, investments in prevention, including the targeting of key risk factors for cancer (including smoking, overweight and obesity, and infection), could avert millions of future cancer diagnoses and save many lives worldwide, bringing huge economic as well as societal dividends to countries over the forthcoming decades.
Soluble B-cell maturation antigen in lacrimal fluid as a potential biomarker and mediator of keratopathy in multiple myeloma
Authors: Munawar Umair , Theuersbacher Johanna , Steinhardt Maximilian J. , Zhou Xiang , Han Seungbin , Nerreter Silvia , Vogt Cornelia , Kurian Shilpa , Keller Thorsten , Regensburger Ann-Katrin , Teufel Eva , Mersi Julia , Bittrich Max , Seifert Franziska , Haider Malik S. , Rasche Leo , Hillenkamp Jost , Einsele Hermann , Kampik Daniel , Kortüm K. Martin , Waldschmidt Johannes M.
Published: April 2024

Belantamab mafodotin (belantamab) is a first-in-class anti-BCMA antibody-drug conjugate approved for the treatment of triple-class refractory multiple myeloma. It provides a unique therapeutic option for patients ineligible for CAR-T and bispecific antibody therapy, and/or patients progressing on anti-CD38 treatment where CAR-T and bispecifics might be kept in reserve.
Wider use of the drug can be challenged by its distinct ocular side effect profile, including corneal microcysts and keratopathy. While dose reduction has been the most effective way to reduce these toxicities, the underlying mechanism of this BCMA off-target effect remains to be characterized. In this study, we provide the first evidence for soluble BCMA (sBCMA) in lacrimal fluid and report on its correlation with tumor burden in myeloma patients. We confirm that corneal cells do not express BCMA, and show that sBCMA-belantamab complexes may rather be internalized by corneal epithelial cells through receptor-ligand independent pinocytosis. Using an hTcEpi corneal cell-line model, we show that the pinocytosis inhibitor EIPA significantly reduces belantamab-specific cell killing. As a proof of concept, we provide detailed patient profiles demonstrating that, after belantamab-induced cell killing, sBCMA is released into circulation, followed by a delayed increase of sBCMA in the tear fluid and subsequent onset of keratopathy.
Based on the proposed mechanism, pinocytosis-induced keratopathy can be prevented by lowering the entry of sBCMA into the lacrimal fluid. Future therapeutic concepts may therefore consist of belantamab-free debulking therapy prior to belantamab consolidation and/or concomitant use of gamma-secretase inhibition as currently evaluated for belantamab and nirogacestat in ongoing studies.
Deprem yaşayan bireylerde travma sonrası stres bozukluğu ile yaşam anlamı arasındaki ilişkide umut duygusunun aracı rolü
Authors: Eren İlke , Akoğlu Bahar
Published: April 2024

Amaç: Araştırmada, deprem yaşayan bireylerde travma sonrası stres bozukluğu (TSSB) ile yaşam anlamı arasındaki ilişkide umut duygusunun aracı rolü incelenmiştir. Yöntem: Araştırmanın örneklemi uygun örnekleme yöntemi ile seçilen 06 Şubat 2023 tarihinde Türkiye’de gerçekleşen Kahramanmaraş merkezli depreme maruz kalmış 20-60 yaş aralığındaki 412 yetişkin (296 kadın, 116 erkek) katılımcıdan oluşmaktadır. Çalışmada veri toplama araçları olarak “Sosyo-demografik Bilgi Formu, DSM-5 için Travma Sonrası Stres Bozukluğu Kontrol Listesi, Yaşamda Anlam Ölçeği ve Sürekli Umut Ölçeği” kullanılmıştır.  Bulgular: Yaşamı ekonomik olarak olumsuz etkilenenlerin TSSB ve yaşamda anlam ölçeğinden, anlam arayışı alt ölçeği puanlarının, etkilenmeyenlere göre yüksek olduğu saptanmıştır. Enkaz altında kalanların TSSB puanlarının, kalmayanlara göre daha yüksek olduğu belirlenmiştir. Enkaz altında kalmayanların, kalanlara göre yaşamda anlam ölçeğinden, anlamın varlığı alt ölçeği puanlarının yüksek olduğu bulunmuştur. Depremde evi yıkılanların ve ağır hasarlı olanların TSSB puanlarının az hasarlı ya da sağlam kalanlara göre yüksek olduğu görülmüştür. Evi sağlam ya da az hasarlı olanların yaşam anlamı ve umut puanlarının evi yıkılanlara göre daha yüksek olduğu bulunmuştur. Sonuç: TSSB ile yaşam anlamı arasında ve umut duygusu arasında negatif yönde düşük düzeyde ve anlamlı bir ilişki saptanmıştır. Yaşam anlamı ile umut duygusu arasında pozitif yönde orta ve anlamlı bir ilişki bulunmuştur. TSSB ile yaşam anlamı arasındaki ilişkide aracılık etkisine bakıldığında ise bu ilişkide umut duygusunun kısmi aracı etkisinin olduğu görülmüştür.
Cerrahi duman: Ameliyathanede çalışan sağlık profesyonellerine etkisi ve alınan önlemlerin incelenmesi
Authors: Dikmen Aydın Yeşim , Gürkan Aysel , Kırtıl İnci
Published: April 2024

Amaç: Ameliyathanede çalışan sağlık profesyonellerine cerrahi dumanın etkilerini ve alınan koruyucu önlemleri belirlemektir. Yöntem: Tanımlayıcı türdeki çalışma 18 Şubat-18 Nisan 2019 tarihleri arasında İstanbul ilinde yedi eğitim ve araştırma hastanesinin ameliyathanelerinde çalışan 380 cerrah, hemşire ve anestezi uzmanı/anestezi teknisyeni ile yürütüldü. Veriler, katılımcıların bireysel ve mesleki özellikleri, cerrahi dumandan etkilenme durumları ve alınan koruyucu önlemleri belirlemeye yönelik literatüre dayalı oluşturulan veri toplama formu ile elde edildi. Verilerin değerlendirilmesinde tanımlayıcı istatistiksel yöntemler (sayı, yüzde, ortalama ve standart sapma) ve ki-kare testi kullanıldı.  Anlamlılık p˂0.05 olarak kabul edildi. Bulgular: Katılımcıların yaş ortalaması 31.41±8.03 (min.19-maks.65) yıl olup %51.8’i hemşire, %24.7’si cerrah, %23.5’i anestezi uzmanı/anestezi teknisyeniydi. Katılımcıların %95’inin cerrahi dumana maruz kaldığı, cerrahi dumana maruz kalma açısından meslek, çalışılan ameliyat odası ve ameliyathanede çalışma süresine göre anlamlı fark olduğu bulundu. Cerrahi dumanın solunmasına bağlı katılımcıların en fazla oranda (%20.6) baş ağrısı deneyimlediği ve cerrahi dumandan korunmaya yönelik önlemler arasında en fazla oranda cerrahi maskeyi (%90.2) kullandıkları belirlendi. Sonuç: Çalışma bulguları ameliyathanede çalışan sağlık profesyonellerinin yüksek oranda cerrahi dumana maruz kaldığını ve buna bağlı çeşitli semptomlar deneyimlediklerini, birimlerinde/kurumlarında cerrahi dumandan korunmaya yönelik önlemlerin yetersiz olduğunu gösterdi. Konuya ilişkin farkındalığın arttırılması için eğitim ve çalışmaların yapılması ve cerrahi dumandan korunmaya yönelik yönergelerin uygulanması önerilir.
Analisis Kesejahteraan Perspektif Ekonomi Islam Pada Jasa Penyeberangan Dampak Pembangunan Jembatan Bandar Ngalim Kediri
Authors: Setiawan Ficky Agung , Imron Ali
Published: April 2024

Penelitian tentang dampak pembangunan jembatan Bandar Ngalim terhadap kesejahteraan jasa penyeberangan menjadi penting untuk memahami bagaimana infrastruktur baru dapat mempengaruhi kehidupan masyarakat dan ekonomi di wilayah tersebut. Dengan adanya jembatan, transportasi dan mobilitas di wilayah tersebut dapat meningkat. Penelitian ini dapat memperkirakan dampak positif atau negatif dari peningkatan efisiensi transportasi, termasuk penghematan waktu dan biaya perjalanan bagi penduduk dan pengguna jasa penyeberangan. Penelitian ini bertujuan untuk menganalisis dampak pembangunan jembatan Bandar Ngalim terhadap kesejahteraan jasa penyeberangan di Kota Kediri. Jembatan Bandar Ngalim merupakan proyek infrastruktur yang diharapkan dapat meningkatkan aksesibilitas dan konektivitas kota dengan daerah sekitarnya. Dalam rangka meningkatkan kesejahteraan jasa penyeberangan secara berkelanjutan, penelitian ini merekomendasikan langkah-langkah strategis, termasuk peningkatan manajemen dan pelayanan jasa penyeberangan, peningkatan kerjasama antara pemerintah dan pelaku industri, serta upaya mitigasi dampak lingkungan yang lebih efektif. Metode penelitian yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan mengumpulkan data melalui wawancara, observasi, dan studi dokumen. Responden penelitian meliputi pekerja jasa penyeberangan, pengusaha, dan masyarakat yang menggunakan jasa penyeberangan. Hasil penelitian menunjukkan bahwa pembangunan jembatan Bandar Ngalim telah membawa dampak signifikan terhadap kesejahteraan jasa penyeberangan di Kediri. Penyeberangan menjadi lebih efisien dan cepat sehingga menarik lebih banyak pengguna, meningkatkan pendapatan bagi pekerja jasa penyeberangan
Strategi Kemandirian Berwirausaha Santri Perspektif Etika Bisnis Islam
Authors: Tamalla Alyya Noor , Fauzi Ahmad
Published: April 2024

Kemandirian termasuk sebagai sumber tenaga kerja untuk menghasilkan produk yang berkualitas, baik berupa materi maupun barang dan jasa. Sebagai seorang individu, seorang wirausahawan juga harus mempunyai sesuatu hal yang utama mengenai perilaku, sikap dan kebiasaan yang tumbuh dan berkembang yang dapat dibentuk oleh suatu kondisi lingkungan maupun pengalaman dalam berwirausaha. Kegiatan berwirausaha di Pondok  Pesantren Darussalam Lirboyo meliputi koperasi, kantin, jual beli online. Penelitian ini menggunakan jenis penelitian kualitatif dengan pendekatan studi kasus. Objek dalam penelitian ini adalah kemandirian berwirausaha santri perspektif etika bisnis Islam studi kasus pondok pesantren Putri Unit Darussalam Lirboyo. Metode pengumpulan data yang digunakan dalam penelitian ini adalah dengan melakukan wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa Proses pelaksanaan kemandirian kewirausahaan yang terdapat di Pondok Pesantren Unit Darussalam Lirboyo Kota Kediri, hal ini dapat dibuktikan dengan dibentuknya usaha yang dijalankan. didalam pondok pesantren meliputi kantin, koperasi, dan kegiatan jual beli online. Pelaksanaan Kemandirian Berwirausaha Santri di Pondok Pesantren Putri Unit Darussalam Lirboyo Kediri Perspektif Etika Bisnis Islam. Dibuktikan dengan tetap memperhatikan Prinsip, Manajemen, Marketing, Harga yang digunakan sebagai panduan dalam menjalankan sebuah bisnis atau usahanya.
Entitas Pembiayaan Sindikasi (Al Tamwil Al Mashrifi Al Mujammaâ€™) Perbankan Syariah Berdasarkan Fatwa DSN-MUI Nomor 91/2014
Authors: Jamaluddin Jamaluddin
Published: April 2024

Perbankan Syariah merupakan unit sistem ekonomi Islam yang beroperasi dengan doktrin dan larangan terhadap praktik riba, yang memiliki peran strategis dalam meningkatkan kesejahteraan umat, melalui proses intermediasi kegiatan penghimpunan, penyaluran dana dan penyadiaan jasa keuangan lainnya, berdasarkan prinsip syariah.  Kemampuan survival perbankan syariah di era krisis, telah menarik banyak perhatian para banker konvensional yang kemudian membuka kantor-kantor cabang bank Islam, yang sekarang melebur (mager) menjadi satu bank, yang disebut Bank Syariah Indonesia (BSI). Pembiayaan sindikasi yang dilakukan antara Lembaga Keuangan Syariah (LKS) dengan Lembaga Keuangan Konvensional (LKK) dibolehkan dengan beberapa syarat rekening, dokumen kontrak dan dokumen-dokumen pendukung lainya harus di pisahkan dan tidak dapat disatukan dengan lembaga keuangan syariah, agar tidak tercampur antara yang halal dengan yang ribawi. Metode penelitian ini berdasarkan deskriptif kualitatif dengan pendekatan library research. Sumber penelitian ini hasil kajian buku-buku, jurnal penelitian, kitab kuning dan sumber lain. Teknik pengumpulan data referensi buku, dokumentasi dan literatur lain yang ada korelasinya dengan judul makalah jurnal ini. Berdasarkan hasil pengelolaan data, penelitian ini menunjukan bahwa pembiayaan sindikasi sesuai dengan Fatwa MUI Nomor 91/2014 tentang pembiayaan sindikasi (al-tamwil al-mashrifi al-mujammaâ€™) terhadap perjanjian bagi hasil proyek.
Pengentasan Ekonomi Single Parent Berbasis Pengelolaan Zakat
Authors: Alfan Aufa Muh. , Yustafad Muh. , Fatmah Fatmah
Published: April 2024

Penelitian ini dalam bingkai besar pengelolaan manajemen zakat. Manajemen pengelolaan zakat yang produktif dapat meningkatkan taraf hidup dan perekonomian perempuan single parent. Perempuan single parent banyak mengalami kendala perekonomian karena selama berkeluarga menggantungkan hidup pada hasil kerja pasangan. Penelitian ini dilakukan di Lazisnu Gondang Legi Plosoklaten Kediri yang telah berupaya melakukan pengelolaan zakat dengan orientasi  peningkatan prekonomian perempuan single parent. Penelitian ini adalah penelitian kualitatif dengan analisis pendekatan teori manajemen. Hasil penelitian menunjukkan bahwa pengelolaan zakat produktif di Lazisnu Gondang Legi Plosoklaten Kediri sudah menggunakan teori manajemen secara menyeluruh