bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a management protocol for internal carotid artery injury during endoscopic surgery: A modified Delphi method and single-center multidisciplinary working group
Authors: Hamour Amr F. , Laliberte Frederick , Padhye Vikram , Monteiro Eric , Agid Ronit , Lee John M. , Witterick Ian J. , Vescan Allan D.
Published: July 2022

Background

Intra-operative internal carotid artery (ICA) injury during transnasal endoscopic surgery is a potentially catastrophic event. Such an injury is life-threatening in the immediate setting, with a reported peri-operative mortality rate of 10%. Nasal packing, muscle patches, direct vessel closure, and endovascular techniques have been described as useful strategies for managing ICA bleeds. The objective of this study was to develop a formalized management protocol for intra-operative ICA injury through engagement with a multi-disciplinary panel.

Methods

A modified Delphi method including literature review, iterative rounds of stakeholder feedback, and expert panel discussions was used to develop a management protocol for ICA injury during transnasal endoscopic surgery. The 10-person multi-disciplinary panel included otolaryngologists, neurosurgeons, interventional neuroradiologists, anesthesiologists, and operating room nursing staff.

Results

After three rounds of stakeholder engagement with the expert panel, consensus was reached on important elements to include within the protocol. The protocol was divided in three categories: Alert, Control, and Transfer. ‘Alert’ focusses on early communication with anesthesia and nursing staff. ‘Control’ focusses on techniques to expose the injury and obtain hemostasis or adequate tamponade. Lastly, ‘Transfer’ describes the process of contacting neuro-interventional radiology and safely transferring the patient. A one-page handout of the protocol was developed for placement in operating theatres.

Conclusion

Due to the life-threatening nature of ICA injury, it is imperative that endoscopic sinus and skull base surgeons are prepared to manage this complication. Using a modified Delphi method with a multidisciplinary expert panel, a protocol for management of intra-operative ICA injury was developed.

Graphical Abstract
Russian speakers’ media engagement and acculturation in Finland and Latvia
Authors: Khalimzoda Ilkhom , Siitonen Marko
Published: July 2022

This comparative study looks into Russian speakers’ acculturation in Finland and Latvia by contrasting their cultural involvement and cultural preference Carlson and Güler (J Int Migr Integr 19:625–647, 2018. 10.1007/s12134-018-0554-4) with their self-reported news media use. Drawing on survey data collected from both countries (N = 224), the findings show that participants in both countries scored closer to biculturalism than monoculturalism. Majority of the respondents report predominantly engaging with non-Russian news media sources. However, regardless of the societal context, respondents who were more engaged with Russian news media sources also scored higher on cultural preference (towards Russian culture of origin). Further significant differences and implications are discussed.
Current distribution and disease association of Ixodidae (hard ticks) in Nigeria
Authors: Kyari Stephen , Ogwiji Matthew , Igah Olanrewaju Eyitayo , Orakpogheno Ochuko , Gasaliyu Khadijat Abidemi
Published: July 2022

Background

This review documents the hard tick species that have been reported in Nigeria, their distribution, pathogens transmitted and disease they cause in Nigeria; the literature review considered studies that were conducted between 2000 and 2021.

Main body

The hard tick (Ixodidae) species widely present in the country are those of the genera; Amblyomma, Rhipicephalus/Boophilus, Hyalomma, Ixodes, Dermacentor and Haemaphysalis among which, Amblyomma sp, Hyalomma sp and Rhipicephalus sp. were most widely reported. Ticks cause serious economic losses to the livestock industry via their negative impact on animal health in general and possible transmission of zoonotic pathogens by some species. Ticks’ distribution is favoured by factors which include uncontrolled cross-border movement of animals, lack of strict quarantine measures, extensive animal grazing and suitable climatic condition. Tick-borne diseases commonly reported included Babesiosis, Anaplasmosis, Theileriosis and Ehrlichiosis, while diseases such as Crimean-Congo Haemorrhagic Fever and Africa tick bite fever are under-reported. Also, there is paucity of information on the economic impact of these diseases. Measures that have been implemented in the control of ticks included the use of acaricides and to some extent vaccines.

Conclusions

Ticks and tick-borne diseases constitute serious economic important and studies to fully ascertain these at the national level is recommended. Also, there is need for identification of other species of ticks and under-reported tick-borne diseases to develop more integrated control measures.
Building urban resilience through sustainability-oriented small- and medium-sized enterprises
Authors: Burch Sarah , DiBella Jose , Wiek Arnim , Schaltegger Stefan , Stubbs Wendy , Farrelly Megan , Ness Barry , McCormick Kes
Published: July 2022

The unfolding COVID-19 pandemic, and the unprecedented social and economic costs it has inflicted, provide an important opportunity to scrutinize the interplay between the resilience of small and medium-sized enterprises (SMEs) and the resilience of the communities they are embedded in. In this article, we articulate the specific ways that SMEs play a crucial, and underappreciated role in building resilience to human and natural hazards, and provide new opportunities to accelerate the adoption of sustainability practices through the configuration of ‘enabling ecosystems’ geared towards promoting sustainability in the private sector. We argue that capacity-building and experimentation are not only required within companies, but also throughout this emerging supportive ecosystem of policies, resources (i.e. finance, materials, skills), governance actors, and intermediaries to adequately focus investment, technical capabilities and innovation. Ultimately, we call for a new transdisciplinary action research agenda that centers on SMEs as pivotal actors and amplifiers of community resilience; while recognizing that these firms are themselves in need of support to secure their own capacity to respond to, and transform in light of, crises. This research program calls for recognizing and applying the lessons that the pandemic presents to the urgent need for accelerated climate action. This will be enabled by developing more targeted approaches to collaborative capacity-building activities in SMEs that feed into experimentation and allow for the accelerated adoption of deliberate and strategic resilient business practices and models.
The role of chronic physical illness and job dissatisfaction on burnout’s risk among medical interns in Oman: a study of prevalence and determinants
Authors: Al-Mahrouqi Tamadhir , Al-Sinawi Hamed , Al-Ghailani Abdullah , Al-Balushi Naser , Jose Sachin , Al-Alawi Mohammed
Published: July 2022

Background

Medical interns are at risk of burnout due to several organizational and individual factors. There is scarcity of studies exploring the role of chronic physical illness and job dissatisfaction on burnout experience among medical interns. This study examined the prevalence of burnout syndrome and explored whether chronic physical illness and job dissatisfaction could independently predict burnout syndrome among medical interns in Oman. This cross-sectional study was conducted among a random sample of medical interns enrolled in the Omani internship program. One-hundred and eighty interns participated in this study and filled in a self-reported questionnaire that included Maslach Burnout Inventory (MBI), Job Satisfaction Survey (JSS), and data related to physical illness.

Results

The prevalence of burnout syndrome was 15%. Having a physical illness (OR = 7.285, 95% CI = 1.976–26.857, P = 0.003) and job dissatisfaction (OR = 16.488, 95% CI = 5.371–50.614, P = 0.0001) was significant independent predictors of high levels of the EE subscale. In addition, having a physical illness (OR = 4.678, 95% CI = 1.498–14.608, P = 0.008) and being dissatisfied (OR = 2.900, 95% CI = 11.159–7.257, P = 0.023) were significant independent predictors of the high DP subscale. Having physical illness was independent predictors of the low personal accomplishment subscale (OR = 0.258, 95% CI = 0.088–0.759, P = 0.014).

Conclusions

Burnout syndrome is prevalent among medical interns in Oman. Job dissatisfaction and chronic physical illness are risk factors for burnout syndrome. Internship programs should consider these factors when designing burnout mitigative strategies.
Depression, anxiety, substance misuse and self-harm in children and young people with rare chronic liver disease
Authors: Chang Wai Hoong , Foster Graham R. , Kelly Deirdre A. , Lai Alvina G.
Published: July 2022

The burden of mental illness in young people with chronic liver disease is not known. In this population cohort study in England, we identified 358 individuals (aged ≤25 years) diagnosed with autoimmune hepatitis or liver disease related to cystic fibrosis and 1541 propensity-score-matched controls. By the first year of follow-up, the cumulative burden of psychiatric events in participants with liver disease was high compared with controls: anxiety disorder (6.87 per 100 individuals [95% CI 4.00–9.73] v. 2.22 [95% CI 1.37–3.07]), depression (5.10 [95% CI 2.83–7.37] v. 0.86 [95% CI 0.53–1.19]), substance misuse (10.61 [95% CI 9.50–11.73] v. 1.23 [95% CI 0.71–1.75]) and self-harm (3.09 [95% CI 1.12–5.05] v. 0.20 [95% CI 0.07–0.33]). Participants with liver disease had a 2-fold increase (OR = 1.94, 95% CI 1.45–2.58), a 2.5-fold increase (OR = 2.59, 95% CI 1.91–3.50) and 4.4-fold increase (OR = 4.44; 95% CI 3.46–5.71) in the risk of anxiety, depression and substance misuse, respectively. These findings highlight the need for effective intervention in psychiatric disorders in young people with rare liver disease.
Comparing personalized brain-based and genetic risk scores for major depressive disorder in large population samples of adults and adolescents
Authors: Thng Gladi , Shen Xueyi , Stolicyn Aleks , Harris Mathew A. , Adams Mark J. , Barbu Miruna C. , Kwong Alex S. F. , Frangou Sophia , Lawrie Stephen M. , McIntosh Andrew M. , Romaniuk Liana , Whalley Heather C.
Published: July 2022

Background

Major depressive disorder (MDD) is a polygenic disorder associated with brain alterations but until recently, there have been no brain-based metrics to quantify individual-level variation in brain morphology. Here, we evaluated and compared the performance of a new brain-based ‘Regional Vulnerability Index’ (RVI) with polygenic risk scores (PRS), in the context of MDD. We assessed associations with syndromal MDD in an adult sample (N = 702, age = 59 ± 10) and with subclinical depressive symptoms in a longitudinal adolescent sample (baseline N = 3,825, age = 10 ± 1; 2-year follow-up N = 2,081, age = 12 ± 1).

Methods

MDD-RVIs quantify the correlation of the individual’s corresponding brain metric with the expected pattern for MDD derived in an independent sample. Using the same methodology across samples, subject-specific MDD-PRS and six MDD-RVIs based on different brain modalities (subcortical volume, cortical thickness, cortical surface area, mean diffusivity, fractional anisotropy, and multimodal) were computed.

Results

In adults, MDD-RVIs (based on white matter and multimodal measures) were more strongly associated with MDD (β = 0.099–0.281, PFDR = 0.001–0.043) than MDD-PRS (β = 0.056–0.152, PFDR = 0.140–0.140). In adolescents, depressive symptoms were associated with MDD-PRS at baseline and follow-up (β = 0.084–0.086, p = 1.38 × 10−4−4.77 × 10−4) but not with any MDD-RVIs (β < 0.05, p > 0.05).

Conclusions

Our results potentially indicate the ability of brain-based risk scores to capture a broader range of risk exposures than genetic risk scores in adults and are also useful in helping us to understand the temporal origins of depression-related brain features. Longitudinal data, specific to the developmental period and on white matter measures, will be useful in informing risk for subsequent psychiatric illness.
Revisiting Pituitary Apoplexy
Authors: Donegan Diane , Erickson Dana
Published: July 2022

Pituitary apoplexy (PA) is a rare clinical syndrome due to pituitary hemorrhage or infarction. It is characterized by the sudden onset of one or more of the following: severe headache, visual disturbance, nausea/vomiting, and or altered mental status. Most commonly, PA occurs in an underlying pituitary adenoma. The pathophysiology is not fully understood, but it is thought to involve elements of increased metabolic demand and/or compromise to the vasculature of the pituitary or pituitary tumor. Several risk factors have been described. Stabilization of the patient on presentation, replacement of hormonal deficiencies, and reversal of electrolyte abnormalities are the recommended initial steps in the management of patients with PA. Surgical decompression of the mass effect had been the recommended treatment for patients with PA; however, retrospective studies of patients with PA have demonstrated similar outcomes when a conservative approach is applied. This suggests that in highly selected clinical scenarios (mild visual deficit and improving symptoms), conservative management is possible. Further studies, however, are necessary to better stratify patients but are limited by the rarity of the condition and the acuity.
Transformista, Travesti, Transgénero
Authors: Santana M. Myrta Leslie
Published: July 2022

This essay considers the stories of Blaccucini and Ángel Daniel, two Black transgender drag performers from Cuba, and dwells on the relationship they imagine between their work as performers and their subjectivities as trans people. The author situates these narratives within queer Cuban and Caribbean studies, noticing the ways they push back against renderings of gender and sexuality as inherently distinct categories. Instead, for these artist-thinkers, trans subjectivity is informed by various experiences related to gender, sexuality, race, class, and geography. The essay offers some possibilities for greater nuance in accounts of sexual subjectivity in Cuba and the Caribbean and locates the stakes of these discussions in broader transnational LGBT rights discourses.
Drosophila CTP synthase regulates collective cell migration by controlling the polarized endocytic cycle
Authors: Wang Pei-Yu , Chakraborty Archan , Ma Hsin-Ju , Wu Jhen-Wei , Jang Anna C.-C. , Lin Wei-Cheng , Pi Hai-Wei , Yeh Chau-Ting , Cheng Mei-Ling , Yu Jau-Song , Pai Li-Mei
Published: July 2022

Phosphatidylinositol (PI) 4,5-bisphosphate (PIP2) is involved in many biological functions. However, the mechanisms of PIP2 in collective cell migration remain elusive. This study highlights the regulatory role of cytidine triphosphate synthase (CTPsyn) in collective border cell migration through regulating the asymmetrical distribution of PIP2. We demonstrated that border cell clusters containing mutant CTPsyn cells suppressed migration. CTPsyn was co-enriched with Actin at the leading edge of the Drosophila border cell cluster where PIP2 was enriched, and this enrichment depended on the CTPsyn activity. Genetic interactions of border cell migration were found between CTPsyn mutant and genes in PI biosynthesis. The CTPsyn reduction resulted in loss of the asymmetric activity of endocytosis recycling. Also, genetic interactions were revealed between components of the exocyst complex and CTPsyn mutant, indicating that CTPsyn activity regulates the PIP2-related asymmetrical exocytosis activity. Furthermore, CTPsyn activity is essential for RTK-polarized distribution in the border cell cluster. We propose a model in which CTPsyn activity is required for the asymmetrical generation of PIP2 to enrich RTK signaling through endocytic recycling in collective cell migration.
Microgel culture and spatial identity mapping elucidate the signalling requirements for primate epiblast and amnion formation
Authors: Munger Clara , Kohler Timo N. , Slatery Erin , Ellermann Anna L. , Bergmann Sophie , Penfold Christopher A. , Ampartzidis Ioakeim , Chen Yutong , Hollfelder Florian , Boroviak Thorsten E.
Published: July 2022

The early specification and rapid growth of extraembryonic membranes are distinctive hallmarks of primate embryogenesis. These complex tasks are resolved through an intricate combination of signals controlling the induction of extraembryonic lineages and, at the same time, safeguarding the pluripotent epiblast. Here, we delineate the signals orchestrating primate epiblast and amnion identity. We encapsulated marmoset pluripotent stem cells into agarose microgels and identified culture conditions for the development of epiblast- and amnion-spheroids. Spatial identity mapping authenticated spheroids generated in vitro by comparison with marmoset embryos in vivo. We leveraged the microgel system to functionally interrogate the signalling environment of the post-implantation primate embryo. Single-cell profiling of the resulting spheroids demonstrated that activin/nodal signalling is required for embryonic lineage identity. BMP4 promoted amnion formation and maturation, which was counteracted by FGF signalling. Our combination of microgel culture, single-cell profiling and spatial identity mapping provides a powerful approach to decipher the essential cues for embryonic and extraembryonic lineage formation in primate embryogenesis.
BRAVO self-confined expression through WOX5 in the Arabidopsis root stem-cell niche
Authors: Mercadal Josep , Betegón-Putze Isabel , Bosch Nadja , Caño-Delgado Ana I. , Ibañes Marta
Published: July 2022

In animals and plants, stem-cell niches are local microenvironments that are tightly regulated to preserve their unique identity while communicating with adjacent cells that will give rise to specialized cell types. In the primary root of Arabidopsis thaliana, two transcription factors, BRAVO and WOX5, among others, are expressed in the stem-cell niche. Intriguingly, BRAVO, a repressor of quiescent center divisions, confines its own gene expression to the stem-cell niche, as evidenced in a bravo mutant background. Here, we propose through mathematical modeling that BRAVO confines its own expression domain to the stem-cell niche by attenuating a WOX5-dependent diffusible activator of BRAVO. This negative feedback drives WOX5 activity to be spatially restricted as well. The results show that WOX5 diffusion and sequestration by binding to BRAVO are sufficient to drive the experimentally observed confined BRAVO expression at the stem-cell niche. We propose that the attenuation of a diffusible activator can be a general mechanism acting at other stem-cell niches to spatially confine genetic activity to a small region while maintaining signaling within them and with the surrounding cells.
Ocean acidification impacts sperm swimming performance and pHi in the New Zealand sea urchin Evechinus chloroticus
Authors: Hudson Michael E. , Sewell Mary A.
Published: July 2022

In sea urchins, spermatozoa are stored in the gonads in hypercapnic conditions (pH<7.0). During spawning, sperm are diluted in seawater of pH>8.0, and there is an alkalinization of the sperm's internal pH (pHi) through the release of CO2 and H+. Previous research has shown that when pHi is above 7.2–7.3, the dynein ATPase flagellar motors are activated, and the sperm become motile. It has been hypothesized that ocean acidification (OA), which decreases the pH of seawater, may have a narcotic effect on sea urchin sperm by impairing the ability to regulate pHi, resulting in decreased motility and swimming speed. Here, we used data collected from the same individuals to test the relationship between pHi and sperm motility/performance in the New Zealand sea urchin Evechinus chloroticus under near-future (2100) and far-future (2150) atmospheric PCO2 conditions (RCP 8.5: pH 7.77, 7.51). Decreasing seawater pH significantly negatively impacted the proportion of motile sperm, and four of the six computer-assisted sperm analysis (CASA) sperm performance measures. In control conditions, sperm had an activated pHi of 7.52. Evechinus chloroticus sperm could not defend pHi in future OA conditions; there was a stepped decrease in the pHi at pH 7.77, with no significant difference in mean pHi between pH 7.77 and 7.51. Paired measurements in the same males showed a positive relationship between pHi and sperm motility, but with a significant difference in the response between males. Differences in motility and sperm performance in OA conditions may impact fertilization success in a future ocean.
O novo papel do vendedor
Authors: Rodrigues Wagner Torres , Do Prado Lucas Sciencia , Zamith Brito Eliane Pereira
Published: July 2022

Com as compras cada vez mais automatizadas, há uma mudança de foco na força de vendas para uma abordagem mais especializada, planejada e de longo prazo.
O que mudou no trabalho do CEO
Authors: Silveira de Almeida João Mendes
Published: July 2022

Quem ocupa o topo das organizações precisa estar em constante aprendizado para poder guiar (sem cartilha) os negócios nesse período de grande transformação pelo qual estamos passando.
Liderança a distância
Authors: Dos Santos Vanessa Martins , Saraiva Guilherme
Published: July 2022

Como os gestores podem melhorar a comunicação remota e não perder a conexão com a equipe.
Ferramentas para empreender
Authors: Sarfati Gilberto
Published: July 2022

O ideia ao negócio é um modelo gratuito gestado na fgv eaesp para impulsionar a criação de startups e constitui uma contribuição brasileira ao movimento lean startup.
O dia a dia na pandemia: trabalho escola e família
Authors: Braga Beatriz Maria
Published: July 2022

A pandemia trouxe mudanças significativas em todos os campos, mas o que de fato aprendemos em relação à vida e ao trabalho nesse período?
Μοντέλα κινδύνου έναντι κατολισθήσεων με χρήση μεθόδων και τεχνικών εξόρυξης γνώσης
Authors: Ντελής Γεώργιος
Published: July 2022

Η ολοένα συχνότερη εμφάνιση ακραίων φυσικών καταστροφών συνιστά μια πραγματικότητα με την οποία ερχόμαστε πλέον αντιμέτωποι όλοι οι άνθρωποι στην πλειοψηφία μας και η οποία δεν δύναται επ' ουδενί λόγω να παραβλεφθεί τόσο ως προς την εντατικοποίησή της όσο και ως προς την γενικότερη έκταση που τα φαινόμενα αυτά λαμβάνουν. Ειδικότερα, η εκδήλωση γεωλογικών μετακινήσεων, και δη των κατολισθητικών γεγονότων, αποτελούν έναν κίνδυνο ο οποίος συναντά δυσκολίες αφενός μεν σε σχέση με τον χωρικό και τον χρονικό προσδιορισμό του, αφετέρου δε σε ότι αφορά την ποσοτική του προσέγγιση. Συνεπώς, τα τρία μείζονα ερωτήματα που γεννώνται είναι το πού, το πότε και το πόσο. Τρία απλά και μονολεκτικά ερωτήματα, όμως ταυτόχρονα με δυσθεώρητο περιεχόμενο και πληθώρα απαντήσεων όπου αναμφίβολα εμπεριέχεται αβεβαιότητα. Ο μηχανισμός των κατολισθήσεων, από τη γενεσιουργό αιτία η οποία μπορεί να είναι μία ή ακόμη και περισσότερες, μέχρι το έναυσμα καθώς και το τελικό στάδιο της εκδήλωσης του φαινομένου, συγκροτεί μέρος μίας διαδικασίας η οποία κρίνεται ως εκ των ων ουκ άνευ προαπαιτούμενο στάδιο στο γενικότερο πλαίσιο που στοχεύει στον επακριβέστερο προσδιορισμό του εν λόγω κινδύνου. Έτσι, λογίζεται ως αδήριτη ανάγκη η ενδελεχής διερεύνηση του προαναφερθέντα μηχανισμού, με απώτερο στόχο την πληρέστερη ερμηνεία και εν τέλει την αποκωδικοποίηση των γεωλογικών αστοχιών. Ωστόσο, δεν πρέπει σε καμία περίπτωση να παραβλέπεται το γεγονός ότι η εκάστοτε περιοχή και τα ιδιαίτερα χαρακτηριστικά - γνωρίσματά της, είναι αυτά που επιπλέον συνθέτουν το "παζλ" της πολυπλοκότητας των κατολισθητικών συμβάντων, με αποτέλεσμα κάθε περίπτωση να είναι ξεχωριστή και να διακρίνεται από μοναδικότητα, αφού συνυπολογίζονται διαφορετικοί συντελεστές συναρτήσει των παραμέτρων βαρύνουσας σημασίας και της κρίσεως του ερευνητή. Στην παρούσα διδακτορική διατριβή διερευνώνται οι παράγοντες εκείνοι οι οποίοι δρουν αιτιωδώς στην εκδήλωση των κατολισθητικών κινήσεων επηρεάζοντας την εμφάνισή τους είτε μεμονωμένα είτε και συνδυαστικά. Επισημαίνεται δε, ότι η επιλογή των παραγόντων αυτών, πραγματοποιήθηκε έπειτα από συλλογή προγενέστερων μελετών και δημοσιεύσεων που αφορούν την υπό εξέταση περιοχή αξιολογώντας σε κάθε περίπτωση τα στοιχεία καθώς και τα προκύπτοντα αποτελέσματα. Ακολούθως αποτυπώνεται συνοπτικά το περιεχόμενο κάθε κεφαλαίου χωριστά αναδεικνύοντας έτσι ουσιαστικά την προσεγγιστική μέθοδο που ακολουθήθηκε για την κατολισθητική εκτίμηση.
Essays on the hellenic energy exchange
Authors: Ιωαννίδης Φίλιππος
Published: July 2022

Με γνώμονα την απελευθέρωση της αγοράς ενέργειας που ξεκίνησε τη δεκαετία του 1990, η Ευρωπαϊκή Ένωση στοχεύει στην ενοποίηση της εσωτερικής της αγοράς και στην επίτευξη σύγκλισης των τιμών ανάμεσα στις Ευρωπαϊκές Οικονομίες. Η πλειονότητα των Ευρωπαϊκών χωρών έχει εγκαθιδρύσει με επιτυχία Χρηματιστήρια Ενέργειας, με στόχο τη διενέργεια διασυνοριακών συναλλαγών με διαφανή και αξιόπιστο τρόπο. Αρχικά, η παρούσα διατριβή παρέχει μια ολοκληρωμένη επισκόπηση της υπάρχουσας βιβλιογραφίας αναφορικά με τον σχεδιασμό της αγοράς των Ευρωπαϊκών Χρηματιστηρίων Ηλεκτρικής Ενέργειας. Στη συνέχεια, επισημαίνονται οι πρόσφατες εξελίξεις στην αγορά ηλεκτρικής ενέργειας της Ελλάδας, συνοδευόμενες από τον σχεδιασμό της αγοράς του Ελληνικού Χρηματιστηρίου Ενέργειας και τις νεοεισαχθείσες αγορές. Το Χρηματιστήριο Ενέργειας αναμένεται να διευκολύνει την ενοποίηση της Ελλάδας με τις υπόλοιπες αγορές ηλεκτρικής ενέργειας της Νοτιοανατολικής Ευρώπης και να αυξήσει την κοινωνική ευημερία. Στο πλαίσιο αυτό, το Μοντέλο-Στόχος (Target Model) στοχεύει στην ολοκλήρωση της Ευρωπαϊκής αγοράς ενέργειας με την άρση των εμποδίων στο εμπόριο και την ευθυγράμμιση των αγορών. Το Target Model αποσκοπεί στην παροχή σταθερών τιμών, στην ενίσχυση της ρευστότητας, στην υποστήριξη των διασυνοριακών συναλλαγών, στη διευκόλυνση των διασυνδέσεων και στο συντονισμό της χρήσης της ισχύος του συστήματος μεταφοράς. Στη συνέχεια, το τρίτο κεφάλαιο εξετάζει την εφαρμογή του Target Model στη χονδρεμπορική αγορά ηλεκτρικής ενέργειας της Ελλάδας και τον αντίκτυπό του στις τιμές της ηλεκτρικής ενέργειας. Το μέρος αυτό διερευνά τη χρονική περίοδο πριν από την εφαρμογή του Target Model, η οποία πραγματοποιήθηκε τον Νοέμβριο του 2020, και επικεντρώνεται στους πρώτους εννέα μήνες της εφαρμογής του. Με βάση την υπάρχουσα εμπειρία από οι υπόλοιπες Ευρωπαϊκές χώρες, η μεταβατική αυτή χρονική περίοδος θεωρείται κρίσιμη, κατά την οποία λαμβάνουν χώρα πολλές στρεβλώσεις και ανήθικες συμπεριφορές. Τα εμπειρικά ευρήματα αποτυπώνουν μια σχετικά επιτυχημένη εφαρμογή του Target Model στην Ελλάδα, με τις διαταραχές των τιμών να παρατηρούνται κυρίως στην Αγορά Εξισορρόπησης. Τέλος, στο τελευταίο μέρος της παρούσας διατριβής παρουσιάζεται μια εκτενής σύγκριση μεταξύ δημόσιων και ιδιωτικών μονάδων φυσικού αερίου στην Ελλάδα. Και οι δύο πλευρές επιδιώκουν να μεγιστοποιήσουν τα κέρδη τους διαχειριζόμενες το “Πρόβλημα Ένταξης των Μονάδων, Unit Commitment Problem” στο πλαίσιο της ελληνικής αγοράς ηλεκτρικής ενέργειας. Με τη χρησιμοποίηση μίας μοναδικής βάσης ωριαίων δεδομένων από το 2015-2019, η εμπειρική προσέγγιση χρησιμοποιεί σταθμισμένες ως προς τον κίνδυνο μετρήσεις επιδόσεων - ταμειακές ροές σε κίνδυνο και σταθμισμένη ως προς τον κίνδυνο απόδοση - για την αξιολόγηση των επιδόσεων μεταξύ των δημόσιων και ιδιωτικών μονάδων. Τα εμπειρικά ευρήματα αποδεικνύουν ότι οι δημόσιες μονάδες φυσικού αερίου υπερτερούν των ιδιωτικών μονάδων όσον αφορά τη λειτουργική απόδοση, ωστόσο η απόδοση των ιδιωτικών μονάδων φυσικού αερίου αυξάνεται με ταχύτερο ρυθμό και αναμένεται να ξεπεράσει την απόδοση των δημόσιων μονάδων εντός 2-3 ετών.
Translation and psychometric evaluation of the Greek version of the Body Image Guilt and Shame Scale
Authors: Togas Constantinos , Alexias George
Published: July 2022

This study examined the psychometric properties of the Greek version of the Body Image Guilt and Shame Scale (BIGSS) in a community sample (N = 2867) of both genders. A set of questionnaires was administered. It included demographic data, Body Mass Index, the Body Image Guilt and Shame Scale (BIGSS), the Body Appreciation Scale, the Other as Shamer and the Experience of Shame Scale. The best solution for the BIGSS (according to exploratory factor analysis) supported a two-factor structure, similar to that found in the original validation. These two factors reflect body guilt and body shame. One more factor was derived, which corresponds to no body image guilt and shame, and its items serve as fillers in the 15 scenarios of the BIGSS. Cronbach’s α value was .90 for Body Image Shame and .85 for the Body Image Guilt subscales. There was a significant positive correlation of both the Body Image Guilt and the Body Image Shame subscales with the Other as Shamer and the Experience of Shame Scale and a negative one with the Body Appreciation Scale. Gender and BMI significantly predicted the score on the Body Image Guilt and the Body Image Shame subscales and age on the Body Image Guilt subscale. In conclusion, the Greek version of the BIGSS has adequate internal consistency, reliability and construct validity, and it is suitable for research and clinical use.
Διδακτικές αναλογίες και εννοιολογική αλλαγή: ο ρόλος της προϋπάρχουσας γνώσης στην κατανόηση αντι-διαισθητικών επιστημονικών εξηγήσεων μέσα από τη χρήση διδακτικών αναλογιών
Authors: Σκοπελίτη Ειρήνη , Βοσνιάδου Στέλλα
Published: July 2022

Προηγούμενες έρευνες έδειξαν ότι οι αναλογίες που χρησιμοποιούνται σε κείμενα για την διδασκαλία αντι-διαισθητικών επιστημονικών εξηγήσεων, που έρχονται δηλαδή σε πλήρη αντίθεση με τα αισθητηριακά δεδομένα, μπορούν να έχουν θετικές επιδράσεις στη μάθηση. Υποστηρίχθηκε ότι υπάρχει ισχυρή συσχέτιση ανάμεσα στην προϋπάρχουσα γνώση των μαθητών και τα οφέλη που προκύπτουν από τις αναλογίες, αφού συμμετέχοντες με προχωρημένη προϋπάρχουσα γνώση κατανόησαν καλύτερα τις αναλογίες και στον μεταέλεγχο έδωσαν απαντήσεις που ήταν πιο κοντά στην επιστημονική. Παραδόξως όμως, στις έρευνες αυτές υπήρξαν συμμετέχοντες με αφελή προϋπάρχουσα γνώση, που κατανόησαν τις αναλογίες, αλλά και συμμετέχοντες που ενώ κατανόησαν τις αναλογίες, δεν βελτίωσαν τις εξηγήσεις τους στον μεταέλεγχο. Τα ευρήματα αυτά οδήγησαν στη διεξαγωγή έρευνας που στόχο είχε να διερευνήσει περαιτέρω μέσω συνεντεύξεων τη σχέση μεταξύ προϋπάρχουσας γνώσης, κατανόησης της αναλογίας και αποδοχής της επιστημονικής εξήγησης, όταν αυτή δίνεται μέσα από κείμενα που είτε χρησιμοποιούν είτε όχι διδακτικές αναλογίες. Στην έρευνα συμμετείχαν μαθητές της 3ης και 5ης δημοτικού. Χρησιμοποιήσαμε ένα ανοικτού τύπου ερωτηματολόγιο για τη διερεύνηση των γνώσεων των μαθητών σχετικά με τη Γη και την εναλλαγή μέρας/νύχτας και δύο επεξηγηματικά κείμενα. Το ένα εξηγούσε την εναλλαγή μέρας/νύχτας χρησιμοποιώντας μία αναλογία, ενώ το άλλο έδινε την ίδια εξήγηση χωρίς αναλογία. Τα αποτελέσματα έδειξαν ότι για την κατανόηση της επιστημονικής εξήγησης και της αναλογίας προαπαιτείται η κατανόηση της έννοιας της Γης ως ένα σφαιρικό αστρονομικό σώμα που περιλαμβάνει προχωρημένες οντολογικές και αναπαραστασιακές πεποιθήσεις σχετικά με τη Γη. Επιπλέον φάνηκε ότι, ακόμη και αν γίνει κατανοητή η επιστημονική εξήγηση για την εναλλαγή μέρας/νύχτας -κάτι το οποίο διευκολύνεται με τη χρήση διδακτικών αναλογιών-  είναι εξαιρετικά δύσκολο για τους μαθητές να αποδεκτούν μία επιστημονική αντι-διαισθητική εξήγηση, εφόσον οι επιστημολογικές τους πεποιθήσεις δεν είναι προωθημένες, ώστε να τους επιτρέπουν να κατανοήσουν ότι τα πράγματα δεν είναι πάντα όπως τα βλέπουμε με τα μάτια μας. Ως εκ τούτου φαίνεται να απαιτείται η χρήση επιπλέον διδακτικών μεθόδων που θα μπορέσουν να ενισχύσουν τα οφέλη των αναλογιών στη μάθηση.
Μάθηση αντι-διαισθητικών εξηγήσεων υπό το πρίσμα της Θεωρίας Πλαισίου για την εννοιολογική αλλαγή
Authors: Βοσνιάδου Στέλλα
Published: July 2022

Το Ειδικό Αφιέρωμα παρουσιάζει πέντε εργασίες που επεκτείνουν την προσέγγιση της Θεωρίας Πλαισίου για την εννοιολογική αλλαγή σε τομείς που δεν είχαν μελετηθεί έως σήμερα. Οι εργασίες αυτές επίσης αναδεικνύουν τις δυνατότητες της θεωρίας να προβλέψει και να εξηγήσει τις δυσκολίες που έχουν οι μαθητές να κατανοήσουν ορισμένες αντι-διαισθητικές επιστημονικές και μαθηματικές έννοιες και εξηγήσεις και να οδηγήσει σε νέες προσεγγίσεις στη διδασκαλία. Παρόλο που κινούνται στην ίδια γραμμή έρευνας η καθεμία από τις εργασίες έχει τη σημαντική δική της καινοτόμο συνεισφορά.
Εννοιολογική αλλαγή και διδασκαλία υπό το πρίσμα της Θεωρίας Πλαισίου
Authors: Πνευματικός Δημήτρης
Published: July 2022

βοηθά να κατανοήσουμε τους γνωστικούς μηχανισμούς που εμπλέκονται στην οικοδόμηση των νοητικών αναπαραστάσεων και στη νοηματοδότηση της πραγματικότητας. Ιδιαίτερα, βοηθά στην κατανόηση των δυσκολιών που αντιμετωπίζουν τα παιδιά και οι αρχάριοι σε έναν επιστημονικό τομέα στη διαδικασία οικοδόμησης της επιστημονικής γνώσης. Η προϋπάρχουσα γνώση σε κάποιον τομέα που τα άτομα κρίνουν σχετικό με την νέα γνώση ενίοτε εμποδίζει παρά διευκολύνει την απόκτηση της επιστημονικής γνώσης. Η κατανόηση του γνωστικού μηχανισμού, που ενεργοποιείται κατά τον μετασχηματισμό της προϋπάρχουσας διαισθητικής γνώσης σε επιστημονική, επιτρέπει την κατανόηση της δημιουργίας των παρανοήσεων. Ακριβώς αυτή η κατανόηση είναι που τοποθετεί την Θεωρία Πλαισίου στον πυρήνα της Γνωσιακής Επιστήμης και, ταυτόχρονα, ένα ισχυρό εργαλείο για τον σχεδιασμό αποτελεσματικών διδακτικών παρεμβάσεων.
Patient and public involvement in stroke research: a scoping review protocol
Authors: Hall Patricia , Kroll Thilo , Hickey Julianne , Stokes Diarmuid , Lennon Olive
Published: July 2022

Background: Growing consensus supports public and patient involvement (PPI) in research as the lived experience of patients, family carers and users of health and social care services bring unique insights to healthcare research. The impact and burden of stroke present ongoing challenges for those living with its consequences and could potentially limit PPI activity. This review aims to explore PPI in published stroke research to identify and describe the extent, nature and design of PPI activities, the type/s of studies involved and the profile of PPI participants engaged in stroke research.

Methods: This systematic scoping review, guided by the Arksey & O’Malley five step framework, will be reported according to the PRISMA-ScR reporting guidelines. PPI is embedded at each stage of this proposed scoping review from conceptualisation, participation, contribution and collaboration. The Population, Concept, Context (PCC) structure defines the research question which asks - How is PPI in stroke research currently being conducted and how do the study authors report their PPI activities and its impact? A comprehensive range of electronic databases including PubMed, CINAHL, EMBASE, PsychINFO and the Cochrane Database of Systematic Reviews will generate a broad range of studies. Grey literature (e.g. OpenGrey, Lenus) and internationally recognised stroke organisation websites will be searched for additional research reports. Data extraction will adhere to the Joanna Briggs Institute guidelines, with results collated and mapped to the research cycle stage/s.

Conclusions: The outlined scoping review protocol will comprehensively identify and map the existing scientific literature that reports PPI in stroke research. Findings will be presented in relation to PPI conceptualisation, participant profiles and activities in stroke research, volume, type and range of approaches. Knowledge gaps may be identified thereby offering opportunities and recommendations for future priorities for PPI in stroke research.
E-learning English textbook on the topic "Infectious diseases, viruses"
Authors: Musina O.R. , Timeeva L.V. , Yarunina I.V.
Published: July 2022

The authors of this e-learning resource have developed a system of exercises aimed at mastering of professional medical vocabulary and developing skills of working with authentic texts on the topic ""Infectious diseases, viruses"". Each section contains an authentic text that allows students to get aware and to memorize corresponding terminology. The peculiar feature of this e-learning resource is that after each text there is a series of exercises presented to develop skills of working with medical vocabulary. In addition, each section contains a glossary which includes lexical units for the studied topic. The structure of the electronic educational resource allows to fulfill the tasks of mastering medical professional vocabulary and oral speech skills. This e-learning resource consists of 12 sections united by one topic. The e-learning resource offers learners to study both in the classroom and at home to enhance the professional language.
The Backhaul Profit Maximization Problem: Optimization Models and Solution Procedures
Authors: Dong Yuanyuan , Bai Yulan , Olinick Eli , Yu Andrew Junfang
Published: July 2022

We present a compact mixed integer program (MIP) for the backhaul profit maximization problem in which a freight carrier seeks to generate profit from an empty delivery vehicle’s backhaul trip from its last scheduled delivery to its depot by allowing it to deviate from the least expensive (or fastest) route to accept pickup-and-delivery requests between various points on the route as allowed by its capacity and required return time. The MIP is inspired by a novel representation of multicommodity flow that significantly reduces the size of the constraint matrix compared with a formulation based on the classical node-arc representation. This, in turn, leads to faster solution times when using a state-of-the-art MIP solver. In an empirical study of both formulations, problem instances with 10 potential pickup/drop-off locations and up to 72 pickup-and-delivery requests were solved an average 1.44 times faster in real time with our formulation, whereas instances with 20 locations and up to 332 pickup-and-delivery requests were solved an average of 11.88 times faster. The largest instances in the comparative study had 60 locations and up to 3,267 pickup-and-delivery requests; these instances required an average of more than 54 hours of real time to solve with the node-arc–based formulation but were solved in an average of under two hours of real time using our compact formulation. We also present a heuristic algorithm based on our compact formulation that finds near optimal solutions to each of the 60-location instances within 22 minutes of real time and near optimal solutions to instances with up to 80 locations within four and a half hours of real time.
PRAKTIK HYGIENE SANITASI PEMERAH SAPI DENGAN ANCAMAN YANG DITIMBULKAN OLEH C. albicans DI DUSUN GONDANG SLEMAN YOGYAKARTA
Authors: Maulana Muchsin
Published: July 2022

Latar Belakang: Lokasi pemerah sapi di dapati beberapa tempat proses pemerahan susu berada di sebelah kandang sapi, dimana lingkungan kandang tersebut terlihat tidak higienis dengan kotoran sapi terlihat menumpuk di dalam dan diluar kandang, serta di beberapa peternakan sapi fasilitas sanitasi untuk cuci tangan tidak dilengkapi sabun. Peneliti mendapati beberapa tempat proses pemerahan susu berada di sebelah kandang sapi, dimana lingkungan kandang tersebut terlihat tidak higienis dengan kotoran sapi terlihat menumpuk di dalam dan diluar kandang, serta di beberapa peternakan sapi fasilitas sanitasi untuk cuci tangan tidak dilengkapi sabun. Para pemerah susu sapi memiliki kebiasaan atau perilaku tidak menggunakan alat pelindung diri (APD) dengan lengkap seperti sarung tangan, masker, baju khusus dan tutup kepala pada saat melakukan pemerahan, tidak mencuci tangan memakai sabun, serta jarang memandikan sapi sesaat sebelum diperah. Sehingga beberapa masalah tersebut dapat berimplikasi pada kemungkinan terjadinya kontaminasi bakteri pada saat memerah susu.Metode: Jenis penelitian yang digunakan adalah analitik observasional. Jenis rancangan penelitian adalah cross sectional. Varibel bebas dalam penelitian ini adalah tingkat pendidikan, tingkat pengetahuan tentang C.Albicans, tingkat pengetahuan tentang sanitasi, lama beternak, sedangkan variabel terikatnya adalah praktik hygiene sanitasi pemerah sapi.Hasil: Tidak Ada Hubungan antara Tingkat Pendidikan dengan Praktik Hygine Sanitasi Pemerah Sapi di Dusun Gondang, Sleman, Yogyakarta. Tidak Ada Hubungan antara Lama Beternak dengan Praktik Hygine Sanitasi Pemerah Sapi di Dusun Gondang, Sleman, Yogyakarta. Tidak Ada Hubungan antara Tingkat Pengetahuan dengan Praktik Hygine Sanitasi Pemerah Sapi di Dusun Gondang, Sleman, Yogyakarta
HUBUNGAN PENGETAHUAN DAN SIKAP IBU RUMAH TANGGA DENGAN PERILAKU PENGGUNAAN BOTOL MINUMAN PLASTIK SEKALI PAKAI DI DUSUN SOCO KECAMATAN SALAMAN KABUPATEN MAGELANG
Authors: Pinastiti Raras , Mulasari Surahma Asti
Published: July 2022

abstracâ€”Drinking water bottles are often being reused by people to be filled with refill drinking water, which has a high potential to cause cancer. Nearly 75% of women in Soco village, who are working as factory workers and traders, were often seen to use disposable mineral water bottles to place their water into. In other case, there were also women with different occupation who placed their daily drinking water stock in a disposable water bottles, and they often put them in a refrigerator. The purpose of this study was to determine the correlation of knowledge and the behavior of women/housewives in Soco village towards the usage of disposable water bottles as daily usage. Quantitative research with analytic survey methods, using cross sectional approach. The sample in this study amounted to 75 respondents. The sampling technique uses simple random sampling with research instrumentation. Data analysis using the Chi-Square test. The knowledge of women/housewivesâ€™s usage of disposable plastic drink bottles in Soco village is 56% good, and 44% are not good. Good attitude 77,3% and bad 22,7%. Good behavior 54,7% and bad 45,3%. The Chi-Square analysis showed that there was a correlations between the knowledge of housewives of Soco village and the behavior of disposable plastic drink bottles usage (p=0,034, RP=1,818 CI=1,093-3,023) and there was a correlation between women/housewives of Soco villageâ€™s attitudes with the behavior of the usage of disposable water bottles (p=0,008, RP=2,112 CI=1,372-3,252). There is a correlation between knowledge and the attitudes of women/housewives in Soco village and the behavior of disposable plastic bottles usage.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PHBS PADA MAHASISWA FAKULTAS KESEHATAN MASYARAKAT UNIVERSITAS AHMAD DAHLAN
Authors: Fadhila Nisa Alya , Rangkuti Ahmad Faizal
Published: July 2022

Health is a right for every human being. Maintaining, maintaining and improving is a way that health can benefit oneself, family and society. Health behavior can be achieved through awareness as in the application of clean and healthy living behavior (PHBS) where the principle of implementation is prevention is better than cure. The purpose of the study was to determine the factors associated with clean and healthy living behavior in FKM UAD students. This type of research uses quantitative research with analytical methods and cross sectional research design. The sample of this study was FKM UAD students with a total of 158 students who were carried out using a total sampling technique. The research instrument used was an online questionnaire which was distributed via google form. The data analysis used was univariate analysis and bivariate analysis with Chi Square statistical test. The results of the univariate analysis showed that as many as 127 (80.45%) students, the majority were female, 80 (50.6%) students had pocket money <Rp.1.360.000, as many as 155 (98.1%) students the majority have a positive attitude, and as many as 143 (90.5%) students behave well. While the results of the bivariate analysis obtained sex with clean and healthy living behavior p value = 0.176, pocket money with clean and healthy living behavior p value = 0.582, and attitudes with clean and healthy living behavior healthy p value = 0.260. There is no relationship between gender and clean and healthy living behavior, there is no relationship between pocket money and clean and healthy living behavior and clean and healthy living behavior, no there is a relationship between attitude and clean and healthy living behavior.
POSTER SEBAGAI MEDIA EDUKASI PENGGUNAAN MASKER PADA IBU-IBU PKK DI DUSUNDUSUN JAGALAN KLATEN
Authors: Jatmika Septian Emma Dwi , Siswanto Hilmi Amallia Putri
Published: July 2022

Based on interviews with PKK members, it was found that the health proto-col that the residents of Jagalan Hamlet often violated was the use of masks. One of the efforts to increase knowledge is to conduct health education using poster media. This study was conducted to determine the effect of providing education using poster media on PKK mothers' knowledge level. This research is a quasi-experimental research with one group pretest post-test design. The research sample was taken by purposive sampling with a total of 16 people who are members of the PKK. Research data were analy-zed using the Wil-Coxon test. The results showed a significant difference in the knowledge level before and after being given education using poster media (p-value = 0.000 <0.05). Health cadres can develop similar educational methods using poster media for other health education.
ECG of the month
Authors: Regan Martin
Published: July 2022

In this issue's ECG of the month, Martin Regan presents the case of a 32-year-old woman who presented to her GP after experiencing palpitations for 6 months.
An Integrated Mother-Child Health and Education Services Program in India: An Example of Informal Preschool Education
Authors: DEMİRTAŞ İLHAN Seden , TANTEKİN ERDEN Feyza , YALÇIN Fatma
Published: July 2022

Providing high quality and inclusive preschool education for children from families with low socio-economic status especially in developing countries remains a problem to be solved. Within this context, investigating good practices supporting children’s holistic development, well-being and academic success and discussing all aspects of these practices can provide examples for developing countries in making cultural adaptations to their local practices considering their new understanding. An alternative early childhood education program that addresses the needs of the population in its host, India, and introducing this program to field experts and educators was the focus of this current study. The Integrated Child Development Services (ICDS) was launched in 1975. It is a model that differs from other programs for child development and care because it offers the world’s largest mother-child health and education services together. ICDS, which is acknowledged as the flagship program of India, is a governmental program operated through Anganwadi Centers (AWC). The centers serve as an outpost for the first line of health, nutrition, and early learning services for disadvantaged groups including children aged 0 to 6 years, pregnant women, and lactating mothers. This study aims to introduce ICDS to early childhood education professionals, teachers, and policy makers.
A Study on Traffic Prediction for the Backbone of Korea’s Research and Science Network Using Machine Learning
Authors: Park Chanjin , Lee Wonhyuk , Kim Moon-Hyun , Kim Ung-Mo , Kim Taehong , Kim Seunghae
Published: July 2022

To fix network congestion resulting from the increase in high volume traffic in data-intensive science and the increase in internet traffic due to COVID-19, there has been a necessity of traffic engineering through traffic prediction. For this, there have been various attempts from a statistical method such as ARIMA to machine learning including LSTM and GRU. This study aimed to collect and learn KREOENT backbone and subscribers’ traffic volume through diverse machine learning techniques (e.g., SVR, LSTM, GRU, etc.) and predict maximum traffic on the following day.