bluuebunny/crossref_metadata_2025 huggingface dataset:
Xenobots: Applications in Drug Discovery
Authors: Solanki Nilay , Mahant Sagar , Patel Swayamprakash , Patel Mehul , Shah Umang , Patel Alkesh , Koria Hardik , Patel Ashish
Published: May 2022

This review work discusses the applications of xenobots in drug discovery. These are the
world's first tiny robots that are living. Robots are built of metals and other things that benefit humans
to solve various issues; however, in this case, small xenobots were built utilizing Xenopus
laevis, frog embryonic stem cells in the blastocyte stage. Xenobots were created by combining bioscience,
artificial intelligence, and computer science. Artificial intelligence constructs several forms
of design in an in vitro, In-silico model, after which software analyzes the structure; the most substantial
and most noticeable forms are filtered out. Later in vivo development create the design of the
Petri plate using the MMR solution and makes the same form as the in silico approach. Ultimately
evaluation done based on the behavior, movement, function, and features of xenobots. Xenobots are
employed in medical research, pharmaceutical research to evaluate novel dosage forms, also useful
for biotechnological and environmental research. Xenobots can be utilized to cure neurodegenerative
disorders such as Alzheimer's, Parkinson's disease, and cancer-related issues because of their selfrepairing
properties, which allow them to repair normal damaged cells, and convey drugs to their
specific target, and reduce cytotoxicity in mostly malignancy circumstances. In the future, new approaches
will be employed to treat chronic illnesses and their complications.
Molecular Mechanism of Qingchang Suppository in the Treatment of Ulcerative
Colitis Based on Network Pharmacology
Authors: Zhu Lingyu , Lin Zhancheng , Lu Lu
Published: May 2022

Objective:

The study aims to explore the mechanism of Qingchang Suppository in the treatment
of ulcerative colitis from the perspective of network pharmacology.

Methods:

The TCM Pharmacology database and analysis platform (TCMSP) were used to determine the
effective components and related target information of the Qingchang Suppository. The main objective is
to search the target genes related to ulcerative colitis using the GeneCards database. The target abbreviation
is transformed into gene number by Perl language. The Kyoto Encyclopedia of Genes and Genomes
(KEGG) pathway was analyzed by R language. The pharmacological mechanism of Qingchang supply
was discussed, laying the foundation for the next experiment.

Results:

869 indexes of Qingchang Suppository were determined. 368 targets of ulcerative colitis were
obtained. Qingchang Suppository and ulcerative colitis were compared, and 141 overlapping targets were
extracted. The "active ingredient target" network of Qingchang Suppository was constructed. The interaction
between the effective components of Qingchang Suppository and the target of ulcerative colitis was
revealed. The overlapping targets were analyzed for the KEGG pathway and function enrichment to explore
the mechanism of Qingchang Suppository in the treatment of ulcerative colitis.

Conclusion:

Qingchang Suppository has the characteristics of multi-component, multi-target and multichannel,
which provide a new idea and basis for further study on the mechanism of Qingchang Suppository
in the treatment of ulcerative colitis.
The Metabolic Syndrome Puzzles; Possible Pathogenesis and Management
Authors: Marzoog Basheer Abdullah
Published: May 2022

Background and Aims:

Metabolic syndrome is a multifactorial pathophysiological process
with complicated homeostatic disorders that arise from various systematic metabolic defects.
Various theories underlie the development of metabolic syndrome but are fully not understood.

Methods:

Revising PubMed and Scopus literature data on metabolic syndrome pathogenesis and
management.

Results:

The most accepted hypothesis is that a cluster of risk factors combined to obtain a truly
metabolic syndrome. The pathophysiology of the metabolic syndrome depends on the underlying
development path due to insulin resistance or chronic inflammation and is usually combined with
neurohormonal disturbance. Meanwhile, these defects can be inherited via loss of function of certain
genes that lead to severe obesity, early diabetes, or severe insulin resistance (with or without
lipodystrophy). Chronic inflammation is also a driver of metabolic syndrome. Lifestyle is still the
therapy of choice in managing metabolic syndrome, but unfortunately, during the lockdown, most
people could not reserve a healthy regime; therefore, it can also be referred to as a pandemic with
COVID-19.

Conclusions:

This powerful illustration shows how defects in specific encoded proteins located
predominantly in the brain, pancreatic beta-cell, muscle, or fat give rise to these distinct components
of the metabolic syndrome. Primarily, obesity and its sequela are the initiators of metabolic
syndrome. The presence of metabolic syndrome increases the risk and severity of other pathologies'
emergence, even in non-related metabolic syndrome diseases such as COVID-19. The article
provides new insights into the pathogeneses and management of the metabolic syndrome.
Venetoclax in Acute Myeloid Leukemia
Authors: Mihăilă Romeo G.
Published: May 2022

Background:

Substantial progress in the therapeutic arsenal used to treat acute myeloid leukemia became possible in the last decade, as a result of advances in gene editing and descriptive and functional genomics.

Objective:

The aim of this study is to analyze the efficacy and safety of venetoclax in the treatment of acute myeloid leukemia.

Methods:

A mini-review was achieved using the articles published in PubMed and Web of Science in the last year, prior to 05.05.2021, which were searched using the terms “acute myeloid leukemia” and ”venetoclax” and the new patents published in this field.

Results:

BCL-2 inhibitors administered in monotherapy are active against acute myeloid leukemia cells, but their efficacy is partially limited because they do not target other antiapoptotic proteins and venetoclax induced overexpression of the other antiapoptotic molecules. Venetoclax-based combina-tions (including those with hypomethylating agents) were able to improve outcomes for older patients with acute myeloid leukemia, including both remission rates and overall survival. Other drugs used in combination with venetoclax include: FLT3 inhibitors, IDH2 inhibitors, chidamide, ibrutinib, lapa-tinib, mivebresib, triptolide, metabolic inhibitors, nucleoside analogs, and classical chemotherapeu-tics. Both the mechanisms of venetoclax resistance and the ways to overcome it, as well as the adverse effects of venetoclax are analyzed.

Conclusion:

The management of unfit and older patients with acute myeloid leukemia should be personalized and be the result of evaluating patient- and disease-specific factors that are essential to their care. Combinations that include venetoclax are an increasingly well-documented option for many of them.
Biomedical Applications of Polyurethane Hydrogels, Polyurethane Aerogels,
and Polyurethane-graphene Nanocomposite Materials
Authors: Saganuwan Saganuwan Alhaji
Published: May 2022

Background:

The emergence of new diseases poses therapeutic challenges in modern
medicine. Polyurethane hydrogels that comprise polyol, copolymer and extender could be prepared
from diverse chemical compounds with adjuvants such as ascorbic acid and sorbitol, among
others. Their mechano-physicochemical properties are functions of their biological activities.
Therefore, there is a need to assess their therapeutic potentials.

Methods:

Relevant literature on the synthesis and medical uses of polyurethane-hydrogels, polyurethane-
aerogels, and polyurethane-graphene nanocomposite materials was searched in order to
identify their sources, synthesis, mechanical and physiochemical properties, biomedical applications,
chirality, and the relevance of Lipinski's rule of five in the synthesis of oral polyurethane
nanocomposite materials.

Results:

The prepared hydrogels and aerogels could be used as polymer carriers for intradermal,
cutaneous, and intranasal drugs. They can be fabricated and used as prosthetics. In addition, the
strength modulus (tensile stress-tensile strain ratio), biodegradability, biocompatibility, and nontoxic
effects of the polyurethane hydrogels and aerogels are highly desirable properties. However,
body and environmental temperatures may contribute to their instability; hence, there is need to
improve the synthesis of aerogels and hydrogels of polyurethane in order to ensure that they can
last for many years. Alcoholism, diabetes, pyrogenic diseases, mechanical and physical forces, and
physiological variability may also reduce the life span of polyurethane aerogels and hydrogels.

Conclusion:

Synthesis of polyurethane hydrogel-aerogel complex that can be used in complex, rare
biomedical cases is of paramount importance. These hydrogels and aerogels may be hydrophobic,
hydrophilic, aerophobic-aerophilic or amphiphilic, and sometimes lipophilic, depending on
structural components and the intended biomedical uses. Polyurethane graphene nanocomposite
materials are used in the treatment of a myriad of diseases, including cancer and bacterial infection.
Inter/Transgenerational Effects of Drugs of Abuse: A Scoping Review
Authors: Zarrindast Mohammad-Reza , Sadat-Shirazi Mitra-Sadat , Sadeghi-Adl Mahsa , Akbarabadi Ardeshir , Ashabi Ghorbangol , Mokri Azarakhsh
Published: May 2022

Drug addiction is a chronic relapsing disorder that makes it a global problem. Genetics and
environmental factors are the two most important factors that make someone vulnerable to drug addiction.
Investigations in the past decade highlighted the role of epigenetics in the inter/transgenerational
inheritance of drug addiction. A growing body of evidence showed that parental (paternal, maternal,
and biparental) drug exposure before conception changes the phenotype of the offspring, which is correlated
with neurochemical and neurostructural changes in the brain. The current paper reviews the effects
of parental (maternal, paternal, and biparental) exposure to drugs of abuse (opioids, cocaine, nicotine,
alcohol, and cannabis) before gestation in animal models.
Design and Molecular Docking Studies of N-Mannich Base Derivatives of
Primaquine Bearing Isatin on the Targets involved in the Pathophysiology
of Cerebral Malaria
Authors: Purohit Deepika , Dutt Rohit , Kumar Pawan , Kumar Sahil , Kumar Ajit
Published: May 2022

Background::

Malaria is considered one of the life-threatening mosquito-borne infectious
diseases responsible for approximately more than 4,00,000 deaths every year all over the world. Plasmodium
falciparum and Plasmodium vivax are widespread species, but infections caused by the former
are of great concern.

Objective:

Among the various forms of infections associated with Plasmodium falciparum, cerebral
malaria (CM) is the most severe neurological complication, accounting for almost 13% of all malariarelated
mortality. The development of effective therapeutics is urgently needed to overcome the fatality
of this dreadful disease.

Methods:

The present work attempted to design and virtually screen a chemical library of 75 molecules
(N-Mannich base derivatives of primaquine bearing isatin moiety as heterocyclic) by molecular
docking studies against anti-malarial target proteins-Cystein Protease Falcipain-2; Dipeptidyl Aminopeptidase-
1; Dipeptidyl Aminopeptidase-3 and Glycogen synthase Kinase-3β receptors, for evaluating
their anti-malarial potential. Among all studied anti-malarial target receptors, the designed molecules
showed an overall higher affinity for Dipeptidyl Aminopeptidase-3. Furthermore, the molecules
were analyzed for binding affinity and drug-like properties using Lipinski rules, and 30 best hits were
shortlisted and analyzed for the pharmacokinetic profile.

Results:

Two of these hits were found to be more toxic than primaquine, hence were omitted in further
analysis. Later, these 28 hits were docked against two target proteins, (a) Plasmodium falciparum
erythrocyte membrane protein-1 and (b) Intracellular adhesion molecule-1, to determine their efficiency
against cerebral malaria, and the results were recorded. Analysis of docking results led to the identification
of the 8 studied molecules as lead molecules which were selected for chemical synthesis,
in vivo studies, and further preclinical evaluation.

Conclusion:

The molecule DSR 11 was predicted as the most appropriate lead molecule for anti-CM
activity in the present investigation apart from the other seven molecules (DSR4, DSR26, DSR38,
DSR40, DSR49, DSR56, and DSR70).
Microbiome and Development of Ovarian Cancer
Authors: Dhingra Aditi , Sharma Divyani , Kumar Anuj , Singh Shalini , Kumar Pramod
Published: May 2022

Cancer of the female reproductive system involves abnormal cell growth that can potentially
invade the peritoneal cavity resulting in malignancy and disease severity. Ovarian cancer
is the most common type of gynecological cancer, which often remains undiagnosed until the
later stages of the disease or until cancer has metastasized towards the peritoneum and omentum,
compelling it to be a deadly disease complicating the prognosis and therapeutics. Environmental,
genetics and microbial factors are the common mainsprings to the disease. Moreover, human
beings harbor rich microbial diversity in various organs (gut, respiratory tract, reproductive tract,
etc.) as a microbiome, crucially impacting health. Any dysbiosis in the microbial diversity or
richness of the reproductive tract and gut can contribute to preconditions to develop/progress
various diseases, including ovarian carcinoma. The microbiome may have a casual or associate
role in ovarian cancer development, with Proteobacteria being the most dominant taxa in cancer
patients and Firmicutes being the most dominant in a normal healthy adult female. A healthy
estrogen-gut axis has an essential role in estrogen metabolism and utilization. However, estrobolome
(Bacteriodete, Firmicutes, Actinobacteria, and Proteobacteria) dysbiosis has an indirect
association with ovarian carcinoma. Microbes associated with sexually transmitted diseases also
impact the induction and progression of ovarian malignancies. Altogether, the microbes and their
metabolites are incidental to the risk of developing ovarian carcinoma.
Comparison of HPLC and ATR-FTIR Methods for the Determination of
Rosmarinic Acid in Aqueous Leaf Extract of Orthosiphon stamineus.
Authors: Akowuah Gabriel Akyirem , Chen Chow Jie
Published: May 2022

Background:

Rosmarinic acid (RA) is an important natural bioactive compound widely distributed in food plants. ATR-FTIR and HPLC methods for comparative determination of RA in aqueous methanolic extracts of Orthosiphon stamineus leaf samples are described.

Method:

The quantitative determination of RA was performed by using HPLC with UV detection at 340 nm and ATR-FTIR based on peak height location at 1712.29 cm-1.

Results:

The mean recovery of RA was 99.54 ± 1.23% by the HPLC method and 105.48 ± 2.76 by the ATR-IR method. The relative standard deviation for the intra-day and inter-day precision were less than 5% for the HPLC method and less than 8% for the ATR-FTIR method. The limit of detection and limit of quantification values for the HPLC method were 2 ng/ml and 10 ng/ml, respectively. The limit of detection and limit of quantification values for the ATR-FTIR method were 0.14% and 0.83% w/w, respectively. The validated methods were used for the quantification of RA in leaf samples of O. staminues. The results of HPLC and ATR-FTIR methods were comparable.

Conclusion:

ATR-FTIR method is suitable for the routine determination of RA in herbal medicinal products of O. stamineus.
Exploring the Patent Landscape and Innovation of Hydrogel-based Bioinks
Used for 3D Bioprinting
Authors: Fatimi Ahmed
Published: May 2022

Background:

This paper provides a comprehensive overview of the patent situation for hydrogel-
based bioinks used for 3D bioprinting globally. It encapsulates information which could be
used as a reference by researchers in the fields of 3D bioprinting, biomaterials, tissue engineering, and
biomedical engineering, as well as those interested in biomaterials, especially in the formulation of
hydrogels. It can also inform policy discussions, strategic research planning, or technology transfer in
this area. The findings presented hereinafter are considered novel research aspects regarding the used
hydrogels, their preparation methods, and their formulations, as well as the 3D bioprinting process using
hydrogels. Furthermore, the novel part, synthesized patents, is regarded as a breakthrough in hydrogel-
based bioinks.

Methods:

The following research aspects of this study are based on data collection from selected patent
databases. The search results are then analyzed according to publication years, classification, inventors,
applicants, and owners, as well as jurisdictions.

Results:

Based on the earliest priority date, it is possible to precisely assume that 2004 is considered
the starting year of patenting of hydrogel-based bioinks. Furthermore, 2020 was the year with the most
patent documents. According to the findings, the United States, China, and the Republic of Korea are
the most prolific countries in terms of patenting on hydrogel-based bioinks. The most prolific patenting
companies are from the United States, Sweden, and Australia, while universities from the Republic
of Korea and the United States are the academic institutions leading the way. Most inventions of hydrogel-
based bioinks intended for hydrogels or hydrocolloids used as materials for prostheses or for
coating prostheses are characterized by their function or physical properties.

Conclusion:

The state has been reviewed by introducing what has been patented concerning hydrogelbased
bioinks. Knowledge clusters and expert driving factors indicate that the research based on biomaterials,
tissue engineering, and biofabrication is concentrated in the most common patent documents.
Finally, this paper, which gives a competitive analysis of the past, present, and future trends in
hydrogel-based bioinks, leads to various recommendations that could help one to plan and innovate
research strategies.
PERSEROAN PERORANGAN PASCA UU CIPTA KERJA:PERUBAHAN PARADIGMA PERSEROAN TERBATAS SEBAGAI ASOSIASI MODAL
Authors: Kasih Desak
Published: May 2022

The study aimed to analyze the concept of a Limited Liability Company after the enactment of Law Number 11 of 2020 concerning Job Creation, especially concerning the concept of capital association paradigm. This normative legal research uses a statutory, conceptual and comparative approach. The results shows that after the enactment of the Job Creation Law, there is a new form of legal entity, namely an Private Company which is specifically for MSE actors with the aim of facilitating business development for MSE actors by being able to form a legal entity with only one person as the founder/shareholder. This has indicated a change in the paradigm of Limited Liability Companies as a capital association. It is in the form of expansion of the concept of a Limited Liability Company where the establishment of a Private Company for MSEs was founded by 1 (one) person. This is nothing new considering Article 7 paragraph 5 and paragraph (7) of the Company Law that a company can be established only by one shareholder as in the establishment of BUMN and BUMD which is also regulated in the BUMN Law and PP. 45 of 2005 which allows the shares of Persero to be wholly owned by the state.
CRIMINAL ACCOUNTABILITY OF STATE OFFICIALS COMMITTING POLITICAL CORRUPTION IN INDONESIA
Authors: Yuliana Yuliana , Prasetyo Mujiono
Published: May 2022

Political corruption is a form of violation of people’s human rights and is a worrying phenomenon because it is dominated by state officials who have superior positions. This article aims to find out how the reality of law enforcement against corruption is carried out by state officials and how the criminal responsibility of state officials who commit political corruption in Indonesia. This article uses a normative juridical method. The results shows that law enforcement against state officials who commit political corruption has not been carried out optimally. The low demands of prosecutors followed by judges’ verdicts against state officials who commit corruption are the cause of the difficulty of eradicating this crime. The imposition of a maximum criminal threat or life imprisonment for perpetrators of political corruption is something that should be done to create a deterrent effect for the perpetrators or the public who see it. In this case, law enforcement officers must have the courage, integrity, and high morale to be indiscriminate in eradicating political crimes in Indonesia.
ANALYSIS OF THE EU CYBERSECURITY ACT UNDER THE THEORY OF NEOLIBERAL INSTITUTIONALISM
Authors: Ananda Safrida , Putranti Ika , Dir Andi
Published: May 2022

Wannacry Ransomware epidemics have attacked several high-profile companies in European Union creating an EU-wide cybersecurity crisis in the digital economy and social order. In response, European Union established an appropriate regulation in cybercrime namely The Cybersecurity Act. The Act as an international regime does not only gives a permanent mandate that strengthens European Union Agency for Network and Information Security (ENISA) but also establishes The EU Cybersecurity Certification Scheme in order to increase cybersecurity and build cyber resilience in the European Union Digital Single Market. This paper investigates how does the Cybersecurity Act as a business law in maintaining cybersecurity aspect on the European Union Digital Single Market through the theory of neoliberal institutionalism as a framework of thinking. After a series of conduction of literature reviews, this research argues that The Cybersecurity Act would be an appropriate regulation in dealing with the cybersecurity crisis in the digitalized market order. The standardization in The EU Cybersecurity Certification Scheme regulated by The Cybersecurity Act would improve cybersecurity and build cyber resilience in the European Union Digital Single Market.
WILLINGNESS TO PAY (WTP) MAHASISWA EKONOMI UNTUK MENGURANGI TINGKAT KRIMINALITAS DI KAMPUS FE UNY
Authors: Suprayitno Bambang , Nurseto Tejo , Ngadiyono Ngadiyono
Published: May 2022

Abstrak: Besaran Willingness to Pay (WTP) berguna untuk dijadikan pertimbangan bagi pengambil kebijakan. Penelitian ini ditujukan untuk mendapatkan WTP mahasiwa FE UNY dalam rangka mengurangi tindak kejahatan berupa apakah itu berupa property crime maupun non-property crime di kampus serta untuk mengeksplorasi keamanan di kampus dari 300 sampel mahasiswa diperoleh dengan purposive proportional sampling di Kampus FE UNY Karang Malang. Dengan Contingent Valuation Method, penelitian ini berusaha mendapatkan kemampuan membayar para responden. Metode yang digunakan dengan pendekatan ekonometrika serta analisis statistik deskriptif. Hasil penelitian menunjukkan bahwa WTP mahasiswa FE UNY secara rata-rata sebesar Rp106.4rb, di mana WTP mahasiwa prodi P.ADP adalah yang terbesar. Berbagai faktor yang mempengaruhi WTP adalah pendapatan keluarga dan tingkat pendidikan kepala keluarga, status sebagai korban dan pelaku kriminalitas jika dilakukan oleh pegawai, kerusakan fisik, serta tingkat ketaatan ketika biaya kriminalitas menjadi pajak serta tindakan nyata untuk mengantisipasi kejahatan. Artinya mahasiswa mempunyai komitmen yang tinggi dalam menanggung biaya agar kriminalitas berkurang di FE UNY.Abstract: The amount of Willingness to Pay (WTP) is useful as a consideration for policy decision. This study aims to obtain WTP of Faculty of Economics’s students for reducing property crime and non-property crime on campus and to explore campus security from 300 student samples through purposive proportional sampling in Universitas Negeri Yogyakarta (UNY) campus. Utilizing Contingent Valuation Method, this research is carried out to obtain the ability to pay the respondents. The econometric approach and descriptive statistical analysis is carried out to achieve the purpose. On the average, the student’s WTP is Rp106,400 where the students of the P.ADP study program has the largest one. Various factors that influence the level of WTP are family income and education level of the head of the family, the status of victims and criminals if carried out by employees, physical damage, and the level of obedience when the costs of crime become tax and concrete actions to anticipate crime. This means that students have a high commitment to provide the fund for reducing the crime in UNY campus.
UPAYA PERTAHANAN KEBERLANGSUNGAN INDUSTRI KERAJINAN ONIX DAN MARMER KABUPATEN TULUNGAGUNG
Authors: Aris Suseno Wahyu Rizki
Published: May 2022

Abstrak: Penulisan artikel ini bertujuan untuk memberikan analisis mengenai upaya yang dilakukan oleh pelaku usaha kerajinan onix dan marmer dalam mempertahankan keberlangsungan industri yang dimilikinya meliputi pengembangan produk, pengembangan pasar, pengelolaan keuangan dan pendidikan ekonomi keluarga. Penulisan penelitian ini menggunakan pendekatan kualitatif serta jenis metode penelitian fenomenologi. Yang menjadi subyek adalah pelaku usaha kerajinan  onix dan marmer di Kecamatan Campurdarat. Teknik yang digunakan adalah teknik pengambilan data berupa observasi, dokumentasi, wawancara mendalam serta triangulasi. Penelitian ini memperoleh hasil yaitu: (1) pengembangan produk yang digunakan yaitu dengan melakukan modifikasi produk yang sudah ada sebelumnya (2) Pengembangan pasar ini dilakukan dengan memasarkan produk yang sudah diproduksi tidak hanya melalui offline namun juga secara online, seperti media sosial maupun market place, (3) pengelolaan keuangan, sebagian pemilik industri sudah melakukan perencanaan dengan baik terhadap keuangan (4) Pendidikan ekonomi keluarga juga diterapkan oleh pemilik industri sebagai upaya untuk mempertahankan perusahaan yang mereka dirikan.Abstract: The writing of this article aims to provide an analysis of the efforts made by Onix and marble handicraft businesses in maintaining the sustainability of their industries including product development, market development, financial management, and family economic education. The writing of this research used a qualitative approach as well as a phenomenological research method. The subject is the handicraft and marble business actors in the Campurdarat District. The technique used is data collection techniques in the form of observation, documentation, interviews, and triangulation. This research obtained the results, namely: (1) product development used, namely by modifying existing products (2) Market development is carried out by marketing products that have been produced not only through offline but also online, such as social media and market places. (3) financial management, some industrial owners have planned well on finances. (4) Industry owners also apply for family economic education in an effort to maintain the companies they have founded.
BACK MATTER (Publication Ethics, Author Index, Subject Index, Author Biography, Acknowledgment, Template, Author Guidelines)
Authors: - -
Published: May 2022

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FRONT MATTER (Cover, Editorial Team, Focus & Scope, Table of Contents)
Authors: - -
Published: May 2022

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Pengembangan perangkat pembelajaran statistika dan peluang untuk mengembangkan statistical literacy siswa SMP
Authors: Hariyanti Firda , Wutsqa Dhoriva Urwatul
Published: May 2022

Penelitian ini bertujuan untuk (1) menghasilkan perangkat pembelajaran statistika dan peluang untuk mengembangkan statistical literacy siswa SMP yang valid, praktis dan efektif; dan (2) mendeskripsikan karakteristik perangkat pembelajaran statistika dan peluang untuk mengembangkan statistical literacy siswa SMP. Jenis penelitian ini adalah penelitian pengembangan. Pengembangan perangkat pembelajaran menggunakan model Plomp yang terdiri dari tiga tahapan, yaitu analisis, perancangan dan pengembangan prototipe, dan evaluasi. Instrumen penelitian terdiri dari lembar validasi, lembar keterbacaan, lembar penilaian guru, lembar penilaian siswa, lembar observasi keterlaksanaan pembelajaran, dan instrumen tes statistical literacy. Penelitian ini menghasilkan perangkat pembelajaran statistika dan peluang untuk mengembangkan statistical literacy siswa SMP yang terdiri dari RPP dan LKS yang telah memenuhi kriteria valid, praktis, dan efektif. Karakteristik dari hasil pengembangan perangkat pembelajaran statistika dan peluang untuk mengembangkan statistical literacy siswa SMP, yaitu (1) menggunakan model guided discovery learning; (2) adanya kegiatan yang membimbing siswa untuk menginterpretasikan, menyimpulkan, dan mengevaluasi data; dan (3) menggunakan masalah-masalah kontekstual terkait dengan pribadi, sekolah, dan masyarakat. AbstractThe objectives of this study were to (1) produce a statistics and probability teaching kit to develop statistical literacy of junior secondary school students that was valid, practical, and effective; and (2) describe the characteristics of statistics and probability teaching kit to develop statistical literacy of junior secondary school students. This study was research and development. The development of a teaching kit was using Plomp’s model consisting of three stages. Those were analysis, design and development of the prototype, and evaluation. The research instruments consisted of a validation sheet, legibility sheet, teacher's assessment sheet, student’s assessment sheet, learning enforcement observation sheet, and statistical literacy test instruments. This research produced statistics and probability teaching kit to develop statistical literacy of junior secondary school students consisting of a lesson plan and student’s worksheet which have met the criteria valid, practical, and effective. The characteristics of development result from statistics and probability teaching kit to develop statistical literacy of junior secondary school students were (1) using guided discovery learning model; (2) there were activities guide students to interpret, infer, and evaluate data; and (3) using contextual problems related to personal, school, and public
Intervention Mapping of a Gamified Therapy Prescription App for Children With Disabilities: User-Centered Design Approach
Authors: Johnson Rowan W , White Becky K , Gucciardi Daniel F , Gibson Noula , Williams Sian A
Published: May 2022

Background

Mobile health (mHealth) apps for children are increasing in availability and scope. Therapy (physiotherapy, speech pathology, and occupational therapy) prescription apps to improve home or school program adherence work best when developed to be highly engaging for children and when they incorporate behavior change techniques (BCTs) within their design.

Objective

The aim of this study was to describe the development of a user-centered therapy prescription app for children (aged 6-12 years) with neurodevelopmental disabilities (eg, cerebral palsy, autism spectrum disorder, and intellectual disability) incorporating intervention mapping (IM) and gamified design.

Methods

We used an iterative, user-centered app development model incorporating the first 3 steps of IM. We conducted a needs analysis with user feedback from our previous mHealth app study, a literature review, and a market audit. Change objectives were then specified in alignment with the psychological needs of autonomy, competence, and relatedness identified in self-determination theory. From these objectives, we then selected BCTs, stipulating parameters for effectiveness and how each BCT would be operationalized. A gamification design was planned and implemented focusing on maximizing engagement in children. In total, 2 rounds of consultations with parents, teachers, and therapists and 1 round of prototype app testing with children were conducted to inform app development, with a final iteration developed for further testing.

Results

The IM process resulted in the specification of app elements, self-determination theory–informed BCTs, that were embedded into the app design. The gamification design yielded the selection of a digital pet avatar with a fantasy anime visual theme and multiple layers of incentives earned by completing prescribed therapy activities. Consultation groups with professionals working with children with disabilities (4 therapists and 3 teachers) and parents of children with disabilities (n=3) provided insights into the motivation of children and the pragmatics of implementing app-delivered therapy programs that informed the app development. User testing with children with disabilities (n=4) highlighted their enthusiasm for the app and the need for support in the initial phase of learning the app. App quality testing (Mobile Application Rating Scale-user version) with the children yielded means (out of 5) of 4.5 (SD 0.8) for engagement, 3.3 (SD 1.6) for function, 3.3 (SD 1.7) for aesthetics, and 4.3 (SD 1.1) for subjective quality.

Conclusions

mHealth apps designed for children can be greatly enhanced with a systematic yet flexible development process considering the specific contextual needs of the children with user-centered design, addressing the need for behavior change using the IM process, and maximizing engagement with gamification and strong visual design.
HITO – a Health IT Ontology: Using Linked Open Data to describe Libre/Free and Open Source Software (Preprint)
Authors: Jahn Franziska , Ammenwerth Elske , Dornauer Verena , Höffner Konrad , Bindel Michelle , Karopka Thomas , Winter Alfred
Published: May 2022

BACKGROUND

There is a variety of Libre/Free and Open Source Software (LIFOSS) products for medicine and healthcare. To support health care and IT professionals in selecting an appropriate software product for given tasks, several comparison studies and web platforms such as MEDFLOSS.org are available. However, due to the lack of a uniform terminology of health informatics, ambiguous or imprecise terms are used to describe functionalities of LIFOSS. This makes comparisons of LIFOSS difficult and may lead to inappropriate software selection decisions. Using Linked Open Data promises to address these challenges.

OBJECTIVE

We describe LIFOSS systematically with the help of an underlying health IT ontology (HITO). We publish HITO and HITO-based software product descriptions using Linked Open Data to obtain the following benefits: (1) Linking and reusing existing terminologies, and (2) using semantic web tools for viewing and querying the LIFOSS data in the world wide web.

METHODS

HITO is incrementally developed and implemented. First, classes for the description of software products in health IT evaluation studies were identified. Second, requirements for describing LIFOSS were elicited by interviewing the platform operators of the internet platform medfloss.org. Third, for describing domain-specific functionalities of software products, existing catalogues of features and enterprise functions were analyzed and integrated into the HITO knowledge base. Finally, to validate the resulting ontology and catalogues, HITO was used to describe 25 LIFOSS products.

RESULTS

HITO provides a defined set of classes and their relationships to describe LIFOSS in medicine and healthcare. With the help of linked or integrated catalogues for languages, programming languages, licenses, features and enterprise functions, the functionalities of LIFOSS can be precisely described and compared. We publish HITO and the LIFOSS descriptions as Linked Open Data, they can therefore be queried and viewed using different semantic web tools such as an RDF browser, SPARQL queries and faceted search. The advantages of providing HITO as linked open data are demonstrated by practical examples.

CONCLUSIONS

HITO supports unambiguous communication among health IT professionals and researchers. Providing LIFOSS product information as linked open data enables barrier-free and easy access to data which is often hidden in user manuals of software products or even not available at all. Efforts of establishing a unique terminology of medical and health informatics should be further supported and continued.
“I haven’t been diagnosed, but I should be”: Insight into self-diagnoses of common mental health disorders (Preprint)
Authors: Rutter Lauren Alexandra , Howard Jacqueline , Lakhan Prabhvir , Valdez Danny , Bollen Johan , Lorenzo-Luaces Lorenzo
Published: May 2022

BACKGROUND

In recent years, social media has become a rich source of mental health data. However, there is a lack of research on the accuracy and validity of self-reported diagnostic information online.

OBJECTIVE

An analysis of the degree of correspondence between self-reported diagnoses and clinical indicators will afford researchers and clinicians higher levels of trust in social media analysis. We hypothesized that self-reported diagnoses would correspond to validated disorder-specific severity questionnaires across two large online samples.

METHODS

Study 1 participants were 1123 adults from a national Qualtrics panel (mean age= 34.65, SD= 12.56; 56.65% female). Study 2 participants were 2237 college students from a large university in the Midwest (mean age= 19.75, SD= 2.75; 75.25% female). All participants completed an online survey about their mental health, social media use, and demographic information. Additionally, participants reported on whether they had ever been diagnosed with a series of disorders, with the option of selecting “Yes”; “No, but I should be”; “I don’t know,” and “No” for each condition. We conducted a series of analysis of variance (ANOVA) tests to determine whether there were differences between each of the four diagnostic groups and used post-hoc Tukey tests to examine the nature of the differences.

RESULTS

In Study 1, for self-reported mania (F(3, 1097)=2.75,P=.04) somatic symptom disorder (F(3, 1060)=26.75,P< .001) and alcohol use disorder F(3, 1097)=77.73,P< .001), the pattern of mean differences did not suggest that individuals are accurate in their insight to diagnoses. In Study 2, for all disorders but bipolar disorder (F(3, 659)=1.43,P= .23), ANOVA results were consistent with our expectations. Across both studies and for most conditions assessed, individuals who say they have been diagnosed with a disorder had the highest severity scores on self-report questionnaires, but that is closely followed by individuals who have not been diagnosed but believe they should be diagnosed. This was especially true for depression, generalized anxiety, and insomnia. For mania and bipolar disorder, questionnaire scores did not differentiate individuals who had been diagnosed from those who had not.

CONCLUSIONS

In general, if an individual believes they should be diagnosed with a disorder, they are experiencing a degree of psychopathology similar to those who have already been diagnosed. Self-reported diagnoses correspond well with symptom severity on a continuum and can be trusted as clinical indicators, especially in common internalizing disorders like depression and generalized anxiety disorder. Researchers can put more faith into patient self-report, including those that occur in online experiments such as social media posts, when individuals report diagnoses of depression and anxiety disorders. Replication and further study is recommended.
Understanding preconception women’s needs and preferences for digital health resources using co-design (Preprint)
Authors: Walker Ruth Elizabeth , Quong Sara , Oliver Patrick , Wu Ling , Xie Jue , Boyle Jacqueline
Published: May 2022

BACKGROUND

Improving preconception health can benefit all women, their children and families, regardless of their individual pregnancy intentions.

OBJECTIVE

Explore how women engage with digital health resources and online platforms to inform the design and development of a digital health resource to support women to make positive behaviour change for their preconception health.

METHODS

This co-design research followed the Double Diamond process. Phase one, contextualisation and explorative processes to develop a design brief, was undertaken via a series of in-depth interviews with female participants (n = 12) aged 18-45 years over three months. Community advisors (n = 8) provided feedback throughout the process. Qualitative analyses of transcripts from interviews was undertaken by two researchers before a deductive process identified themes mapped to the COM-B framework.

RESULTS

Nine themes and eight sub-themes were identified. Participants were already engaging with a range of digital health resources and had high expectations of these. Digital health resources needed to be easy to access, make women’s busy lives easier, be evidence-based, and be reputable. Social connectedness was also highly important to our participants, with information and advice from peers with similar experiences being preferred over yet more online health information.

CONCLUSIONS

Co-designed digital health resources should be evidence-based, reputable and easy to access. Social connections were considered highly important to women and designers of digital health resources should consider how they can increase opportunities for women to connect and learn from each other to promote health behaviours.
A personified approach to the treatment of vegetative disorders in patients with prevential stomach conditions using Pure Purr complex
Authors: Mosyichuk L.M. , Zyhalo E.V. , Shevtsova O.M. , Serdiychenko O.M. , Petishko O.P.
Published: May 2022

Background. Indicators of heart rate variability are reliable and objective indicators of the tone of the autonomic nervous system (ANS), which reflects changes in the psycho-emotional state of man against the background of stress. Stress management programs include a variety of relaxation techniques and cognitive behavioral therapy. Therefore, the purpose of the study was to optimize the treatment of patients with chronic atrophic gastritis with autonomic disorders using software and hardware for parasympathetic activation of the ANS. Materials and methods. Indicators of heart rate variability were studied in 80 patients with chronic atrophic gastritis based on the results of PRECISE diagnostics, which allowed to identify patients with hypersympathicotonia and treat them with 10 sessions on Pure Purr software and hardware complex to assess the dynamics of heart rate variability. Results. 72.7% of patients with chronic atrophic gastritis, who showed a decrease in heart rate variability due to activation of the sympathetic tonic ANS and insufficient activity of its parasympathetic tonic, breakdown of adaptation, lack of stress and functional reserves of the body were treated with neurostimulation. After treatment, positive dynamics was determined in the form of a significant increase in heart rate variability by increasing its components due to the parasympathetic nervous system, which prevents increased sympathetic influences and improves disease and prognosis by normalizing adaptation, functional reserves and stress resistance. Conclusions. Treatment of patients with chronic atrophic gastritis with autonomic disorders should be comprehensive with the inclusion of hardware with neurostimulation software aimed at reducing hypersympathicotonia with increasing adaptive capacity of the body.
Possibilities of ultrasound diagnostics in inflammatory bowel diseases
Authors: Stoikevych M. , Fedorova N. , Nedzvetska N. , Konenko I.
Published: May 2022

The article deals with nosologies that are complex for diagnostic search and management of the patient— ulcerative colitis and Crohn’s disease. To date, the main diagnostic procedure for these diseases is endoscopy with biopsy and histology. However, there are limitations in their conduct and in the assessment of complications and proximal spread of CD. European guidelines for the diagnosis of UC and CD recommend additional imaging methods to diagnose and determine the location, degree and complications, namely ultrasound of the gastrointestinal tract. The article presents clinical cases of UC and CD, in patients who underwent ultrasound of the intestine and shows its high diagnostic value.
Jejak karbon pada tahap operasional agro-eduwisata kota mataram menggunakan pendekatan penilaian daur hidup
Authors: Adiansyah Joni Safaat
Published: May 2022

Climate change is one of the global issues that require the participation of all stakeholders for handling. In addition, the climate change issue is listed as one of the sustainable development goals (SDGs). The Government of Mataram city, as one of the stakeholders, has committed to involve the climate change consideration into its planned program, including the development of agro-edutourism facility. This study aims to calculate a carbon footprint of agroedutourism facility during the operational stage in order to implement the Greenhouse Gas (GHG) emission reduction strategy. The method used is a life cycle assessment approach with ReCiPe analysis, and the functional unit is an annual carbon footprint per m2 area of agro-edutourism. The study showed that the total carbon footprint per m2 was 2.88 KgCO2-e per annum with the primary environmental hotspot was fossil fuel utilization in energy source of agro-edutourism facility (Electricity State-own Company) and visitor vehicles. Therefore, some strategies could be applied for reducing the carbon footprint, such as increasing the utilization percentage of renewable energy (solar panel), using energy-saving bulbs, preparing the facilities for zero-emission vehicles, and applying the green building concept or design. Further research is required to assess the energy management concept from the technical feasibility aspect and economic aspect for complimenting this study.
A Few Words about Pornography
Authors: Franjic Sinisa
Published: May 2022

Pornography is an explicit depiction of sexual intercourse. Unlike erotica, pornography does not strive for artistic expression, but in a faithful way seeks to portray sexual intercourse, with the aim of arousing sexual arousal. In most countries, adult films are considered offensive and as such are subject to censorship. Pornographic content in the form of pictures, stories and personal ads, appear on the market in special magazines, which therefore pay sales tax. There are many websites on the Internet with movie porn and related content, which is the most accessible form of pornography today. It has become customary to label pornographic content as “XXX”.
STUDY OF GENERALISED ANXIETY DISORDER AND FACTORS AFFECTING IT DURING POSTNATAL PERIOD.
Authors: Manish Tiwari  , Pise Harshal N , Mahima Tiwari
Published: May 2022

ABSTRACT

 

Background: Anxiety disorders remain the commonest mental disorder in general population. Both these disorders are common in pregnant women and postpartum period and are underdiagnosed. There is a paucity of research on mental disorders and their risk factors among women during postnatal period in India. This study aims to estimate the incidence of generalised anxiety disorder (GAD) and depression and explore the common associated factors among postnatal women in India.

Aim: The present study aims to study the incidence and risk factors of generalised anxiety disorders among mothers attending the outpatient department clinic (OPD) for vaccination of their children or gynaecology OPD for follow up.

Methods: Total of 180 women of postpartum period, up to 6 months, was randomly selected and assessed using self-report questionnaire GAD-7 for GAD. General demographic details were obtained via a revalidated proforma. Incidence and risk factors for both these mental disorders were assessed.

Results: The incidence of GAD was found to be 31.11%. Primigravida mothers scored higher on GAD-7 score than multigravida mothers and incidence of GAD was also higher in primigravidas mothers (p=0.042). There was no significant association between age of mother, socioeconomic status of mother, and sex of the child born, with development of GAD in the postnatal period. Substance abuse in husband was significantly related to development of GAD in women in postnatal period.

Conclusion: A significant proportion of women had generalised anxiety disorder. Pregnancy for the first time was associated with increased risk of GAD. Substance abuse by husband is significantly associated with development of GAD and depression during postnatal period.