bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of NALCN-Encoded Na+Leak Currents on the Repetitive Firing Properties of SCN Neurons Depend on K+-Driven Rhythmic Changes in Input Resistance
Authors: Yang Nien-Du , Mellor Rebecca L. , Hermanstyne Tracey O. , Nerbonne Jeanne M.
Published: June 2023

Neurons in the suprachiasmatic nucleus (SCN) generate circadian changes in the rates of spontaneous action potential firing that regulate and synchronize daily rhythms in physiology and behavior. Considerable evidence suggests that daily rhythms in the repetitive firing rates (higher during the day than at night) of SCN neurons are mediated by changes in subthreshold potassium (K+) conductance(s). An alternative “bicycle” model for circadian regulation of membrane excitability in clock neurons, however, suggests that an increase in NALCN-encoded sodium (Na+) leak conductance underlies daytime increases in firing rates. The experiments reported here explored the role of Na+leak currents in regulating daytime and nighttime repetitive firing rates in identified adult male and female mouse SCN neurons: vasoactive intestinal peptide-expressing (VIP+), neuromedin S-expressing (NMS+) and gastrin-releasing peptide-expressing (GRP+) cells. Whole-cell recordings from VIP+, NMS+, and GRP+neurons in acute SCN slices revealed that Na+leak current amplitudes/densities are similar during the day and at night, but have a larger impact on membrane potentials in daytime neurons. Additional experiments, using anin vivoconditional knockout approach, demonstrated that NALCN-encoded Na+currents selectively regulate daytime repetitive firing rates of adult SCN neurons. Dynamic clamp-mediated manipulation revealed that the effects of NALCN-encoded Na+currents on the repetitive firing rates of SCN neurons depend on K+current-driven changes in input resistances. Together, these findings demonstrate that NALCN-encoded Na+leak channels contribute to regulating daily rhythms in the excitability of SCN neurons by a mechanism that depends on K+current-mediated rhythmic changes in intrinsic membrane properties.

SIGNIFICANCE STATEMENTElucidating the ionic mechanisms responsible for generating daily rhythms in the rates of spontaneous action potential firing of neurons in the suprachiasmatic nucleus (SCN), the master circadian pacemaker in mammals, is an important step toward understanding how the molecular clock controls circadian rhythms in physiology and behavior. While numerous studies have focused on identifying subthreshold K+channel(s) that mediate day-night changes in the firing rates of SCN neurons, a role for Na+leak currents has also been suggested. The results of the experiments presented here demonstrate that NALCN-encoded Na+leak currents differentially modulate daily rhythms in the daytime/nighttime repetitive firing rates of SCN neurons as a consequence of rhythmic changes in subthreshold K+currents.
MUJERES DE COIMBRA EN LOS MERCADOS, TALLERES Y SERVICIOS PÚBLICOS (1500-1834)
Authors: Lopes Maria Antónia
Published: June 2023

Este artículo estudia las actividades económicas desarrolladas por las mujeres en una ciudad portuguesa, Coimbra, durante la edad moderna, valorando su importancia numérica, su protagonismo y su capacidad de decisión en la vida socioeconómica de la urbe. Se trataba de una ciudad de tamaño mediano, sede episcopal y universitaria, pero bajo esta imagen de ciudad tradicional, tenía una intensa actividad económica que era gestionada y vigilada por la Cámara Municipal, en especial lo referente al suministro diario. Después de aclarar la situación jurídica de las mujeres portuguesas en términos de propiedad y de trabajo —que todavía es objeto de malentendidos—, se subraya que el estado civil no fue determinante para el ejercicio de profesiones autónomas. Utilizando fuentes administrativas y un tratamiento cuantitativo, el artículo se centra en las mujeres que trabajaban por cuenta propia y no en las asalariadas. Se concluye que las mujeres aparecen en múltiples actividades (cerca de cien profesiones diferentes); que eran dos tercios de los comerciantes autónomos, tanto a mediados del siglo XVII como a principios del XIX; que la mayoría de las actividades comerciales no estaban segregadas por género, y hombres y mujeres las realizaban en competencia; que en los siglos XVI y XVII, las mujeres obtenían cartas de examen y estaban integradas en los gremios de una decena de oficios, ya que el cierre de los gremios a las mujeres solo se dio durante el siglo XVIII; y que, si bien las actividades económicas estaban intensamente reguladas y supervisadas por las autoridades municipales, las mujeres a menudo ofrecían resistencia, pasiva o activa a esa regulación.
Monumentalidad en madera: una aproximación preliminar a los círculos de madera de la Prehistoria Tardía en el Sur de Portugal
Authors: Carlos Valera António
Published: June 2023

En la arquitectura monumental y ceremonial de la Prehistoria Reciente peninsular, la madera ha sido considerada fundamentalmente como una materia prima accesoria para la construcción. Este texto presenta dos contextos (Outeiro Alto 2 y Perdigões, sur de Portugal) que, por primera vez, muestran la presencia de monumentos de madera. Se trata de círculos concéntricos de postes y empalizadas de madera, exclusivos en la Península, y que encuentran los paralelos más estrechos en el norte y centro de Europa. Se presentan los datos contextuales y las cronologías disponibles, desarrollando un primer conjunto de consideraciones sobre la importancia que este tipo de arquitectura monumental pudo haber tenido en el contexto de las trayectorias de complejidad social en la segunda mitad del IV y III milenio antes de Cristo.
The Photonegatives of the Ancient Egypt Collection of the Taras Shevchenko Central Hstorical Museum: Review on the Monography by O. O. Romanova and H. O. Stanytsina. Ancient Egypt in Kyiv: Mirrored on Glass (the Glass Photonegatives Collection of the Scie
Authors:   PhD, Senior Research Fellow, the M. S. Hrushevskyi Institute of Ukrainian Archeography and Source Studies of the National Academy of Sciences of Ukraine, the Department of Source Studies of the Modern History of Ukraine, Sebta Tetiana , Tarasenko Mykola ,   DSc., Leading Research Fellow, the A. Yu. Krymskyi Institute of Oriental Studies of the National Academy of Sciences of Ukraine, the Department of the Near and Middle East; Research Fellow, the Faculty of Asian and Middle Eastern Studies, the University of Oxford, Sorokina Svitlana ,   Chief of the Sector “Archaeology of Paleolithic-Bronze Age”, the National Museum of History of Ukraine, the Department of Archaeology
Published: June 2023

The article reviews the monograph-catalogue O. O. Romanova and H. O. Stanytsina Ancient Egypt in Kyiv: mirrored on Glass (the Glass Photonegatives Collection of the Scientific Archive of the Institute of Archaeology of the National Academy of Sciences of Ukraine). This book is dedicated to the introduction into academic circulation of a collection of glass photonegatives depicting ancient Egyptian objects from the Scientific Archive of the Institute of Archaeology of the National Academy of Sciences of Ukraine. 143 negatives and photographs of ancient Egyptian items were collected; they were published and provided with catalogue data and comments. Significant work has been done on the attribution of objects depicted on the negatives. Noting the importance of visual material introduced, the research part of the monograph, however, contains significant intentional or unintentional lacunae regarding the existing base of Ukrainian researches on the topic. The Egyptological part of the work has also a certain number of completely or partially erroneous attributions and statements and ignores existing academic publications on the subject. The reviewers came to somewhat different conclusions regarding the reason for the formation of the discussed collection of negatives, specified the circumstances, time and place of their creation, differently defined individual ancient Egyptian objects and the provenance of some of them (for example, the “shabti-box” on the photonegatives (now lost) is actually a canopic box). Documents from the Scientific Archive of the National Museum of the History of Ukraine are of great importance for revising the conclusions of the monograph. An excerpt from the inventory book of negatives is published, which demonstrates that the collection was created at the Taras Shevchenko National Historical Museum in the process of preparing an exhibition of ancient Egyptian artefacts.
Pemberdayaan Ekonomi Masyarakat Melalui Home Industry
Authors: Sari Puji Maya , Rahmawaty Indira Sabeth
Published: June 2023

This study aims to analyze the community economic empowerment program through the implementation program and the results of community economic empowerment through the tulangsapi craft home industry in Pasirtukul Village. This research method is a qualitative research using descriptive method. Data collection techniques used, interviews, and documentation. Data analysis was carried out through a logical interpretation that spread with the context of Community Economic Empowerment. The results of the study showed that the Community Economic Empowerment program through the home of Cattle Bone craft industry was an activity used to provide information. Build with manufacturers for craftsmen with the aim of improving the economy of the craftsmen. In addition, from this activity the community is given craft tools and procedures for managing production results. The process carried out by agricultural training consists of several stages, namely the pre-implementation stage, the manufacturing process, the process and the discussion. the community is clearer in managing handicrafts; the craftsman community finds more in the home industry; The economic control of the community through industrial houses, cow bone crafts, produces relations and network links for craftsmen to improve their handicrafts
Peran Komunitas Islam dalam Menyemangati Keagamaan para Pemuda
Authors: Utami Istiqomah Bekthi , Safei Agus Ahmad
Published: June 2023

This study aims to find out how the work program, the constraints, the role, the success rate, and the implementation of the program conducted by Pesantren Yatim Al-Hilal in empowering orphaned resources by building the community's caring participation for abandoned orphans. Place research conducted by the author that is in Pesantren Yatim Al-Hilal Village Rancapanggung Kec. Cililin Kab. West Bandung. The method used in this research is descriptive method. Based on the results of research conducted on this Pesantren Yatim Al-Hilal, the authors found out that empowerment of orphans conducted by Al-Hilal pesantren by providing human resource development by improving both social and religious knowledge, by meeting the needs of life for orphans as the realization of the success of orphans in achieving their goals and can be useful for the nation, and the country.
Strategi PT. Holcim Indonesia, Tbk dalam Pemberdayaan Masyarakat Islam
Authors: Hastuti Nuning Widya , Kuswana Dadang , Rahmawaty Indira Sabet
Published: June 2023

The research as a purpose to know and analyzed the strategy and program was made by PT. Holcim Indonesia, Tbk for empowering the Islamic community. And know the implementation fund CSR PT. Holcim Indonesia, Tbk for society. This research form qualitative research used descriptive method. Technique collecting data used observation, interview, and documentation. The analysis data used by logic interpreter connected with the development of Islamic society context. The results of the research that strategy and program PT. Holcim Indonesia, Tbk make 5 pillars to develop of Islamic society that is economy, area, training and education, infrastructure and social, distribution implementation funds CSR take a procedure that is social mapping, organize media communication of society as transparency, the annual budget, make a program appropriate from each village, implementation of program and Monitoring and evaluation. The result of implementation and CSR PT. Holcim Indonesia, Tbk the society explain that satisfied till increase self-confidence to explain aspiration and able to compete, increasing public awareness to create the village economy environment.
Pemberdayaan Lansia Melalui UPTD Panti Sosial Rehabilitasi Lansia Jawa Barat
Authors: Marudi Anggita Ghaidhasani , Sumpena Deden , Herdiana Dedi
Published: June 2023

Increased AHH accompanied by an increase in the elderly population. It is feared to bring impact on socio-economic conditions of the country. The phenomenon must look for a solution, the one with the empowerment program for seniors. UNIT for The Social Rehabilitation and Elderly West Java is one of the Government agencies that become facilitators in the empowerment of the elderly. The goal in this research to know the process of empowerment and continuity in the program of empowerment. Peneltian is done based on the qualitative method through a descriptive approach. The theory in this research is the theory of Hogan that saw that the process of empowerment is a process that goes on all human life derived from individual experience, instead of a process that stops at a time only. The results in this study is granting the empowerment program in the form of skills training where in the process conducted during twice a week and training conducted by a competent instructor, it is aimed so that the creation of the elderly independent work, and quality.
Pemberdayaan Perempuan melalui Perempuan Kepala Keluarga dalam Meningkatkan Ekonomi Keluarga
Authors: Nurgina Siti , Kuswana Dadang , Rahmawaty Indira Sabet
Published: June 2023

This study aims to find out the background of the PEKKA program, the implementation of the program and the results of the PEKKA program on improving the family economy. The research method used is a qualitative method with descriptive research. The results showed that the background of the PEKKA program in the city of Sukabumi began with the adoption of the National Women's Commission program. However, in the City of Sukabumi, this program is aimed at women who want to try and develop to help with income in the family, whether women are widowed or who still have a husband with certain conditions. Implementation of activities in the form of trainings aimed at improving the family's economy. And the results of the PEKKA program on improving family economics are improving living standards, building critical awareness, and meeting family needs.
Peran Komunitas Tjimahi Heritage dalam Melestarikan Warisan Budaya
Authors: Alparisi Muhamad Rajib , Nuraeni Heny Gustini
Published: June 2023

The purpose of this research is to find out how the Tjimahi Heritage community effort in empowering the community through preservation of cultural heritage, how the Tjimahi Heritage community program in empowering the community through preservation of cultural heritage, and the results of community empowerment through preservation of cultural heritage. This research method use qualitative research methods with a descriptive approach. The results of this study indicate that the Tjimahi Heritage community seeks to educate and make people aware through the preservation of cultural heritage. Various programs carried out by the Tjimahi Heritage community to empower people through the preservation of cultural heritage by discussion, exploring, and becoming partners of activities related to history and preservation of cultural heritage. The results obtained are that the community understands the history of their area and creates a senses of concern and love for their region. From the side of the Government of the City of Cimahi began developing military historical tourism which is an asset owned by the City of Cimahi.
DAMPAK PEMBERDAYAAN DESA WISATA HALAL
Authors: Ridwan Rahmat , Dewi Ratna
Published: June 2023

A tourist village is a rural area that offers authenticity both in terms of socio-culture, customs, everyday life, traditional architecture and village spatial structure. The purpose of this study is to find out government policies, changes in people's attitudes and the impact felt on community empowerment. The method used in this research is a qualitative research with descriptive method. The results of the study show that first, the village government's policy towards community empowerment is carried out in the form of empowerment programs such as halal tourism villages, sheep manure management, bamboo management, plastic waste management. Second, the change in attitude that occurred in the community after the existence of the Cibuntu halal tourism village program, the community learned to maintain local culture and wisdom so that it became an attraction for tourists, so that changes in community behavior appeared in a more positive direction such as mutual cooperation, courtesy, hospitality, extra care cleanliness and become more religious than before. Third, the impact felt by the community is very positive, especially towards improving the economy and the community taking part in the empowerment process and management
Pemberdayaan Ibu Rumah Tangga melalui KWT dalam Meningkatkan Kesejahteraan Keluarga
Authors: Khoirunnisa Dinda Citra , Sumpena Deden , Dewi Ratna
Published: June 2023

This study aims to find out about the empowerment program carried out by the Malati Asih Farmer Women's Group, the empowerment process, and the results obtained from the Malati Asih Women's Farmer's Group in Cinanjung Tanjungsari Village, Sumedang Regency. The method used in this study used qualitative and descriptive research methods with data collection through interviews, observation, and documentation studies. The results of research conducted at KWT Malati Asih include: There are two empowerment programs implemented, namely the KRPL program which focuses on managing agriculture in the yard of the house, and the Savings and Loans Cooperative which aims to provide capital for member businesses. The empowerment process is carried out in four stages, namely identifying and assessing regional potential, problems, and opportunities; preparing group activity plans; implementing the activity/implementation plan; and monitoring/supervision. the presence of housewives' products; add insight into the world of agriculture; have skills and can help the family economy and family welfare.
Pemberdayaan Ekonomi Masyarakat oleh Pengusaha
Authors: Nurhadiasari Maudi , Safei Agus Ahmad , Herdiana Dedi
Published: June 2023

This study aims to determine the work steps, obstacles and results of Community Economic Empowerment in PD. Ar-Rahmah. This study uses a qualitative approach with the method used is descriptive method. The results of the study show the work steps for empowering the community's economy carried out by PD. Ar-Rahmah, namely by providing motivation to work and providing directions for work steps to be more independent, as well as providing many new innovations for the progress of the PD tea leaf factory. Ar-Rahmah. Opening employment opportunities, and holding such as a savings and loan cooperative system without interest, and how to pay in salary deductions, or in installments, or due to obstacles Obstacles in empowering the community's economy at PD Ar-Rahmah, namely from an internal and external perspective and the results of the empowerment community economy in PD. Ar-Rahmah is quite well felt by employees and the surrounding community. With the existence of jobs around the place of residence it is not difficult for the community to have to migrate and leave their families
Peran Usaha Kecil dan Menengah (UKM) dalam Meningkatkan Kesejahteraan Masyarakat
Authors: Syaifudin Roy , Shodiqin Asep , Nase Nase
Published: June 2023

The economic problems felt by the lower class of society who then run Small and Medium Enterprises (SMEs) independently, and this in Indonesia is a phenomenon that has indicators of rapid growth. The purpose of this study is to find out how the role and results of the implementation of small and medium enterprises in order to improve community welfare. Qualitative research methods. As for the results obtained, the Role of Small and Medium Enterprises in Prospering the Economy of Village Communities, namely as a seller of Fried Chicken or you could say fried chicken, must be familiar to the Indonesian people. The results of the research show that there are several indicators of successful community development through Fried Chicken fast food, including: a) The emergence of public awareness in increasing and developing potential as fast food entrepreneurs, b) The community also gets increased income from the fast food sector, c) The number of enthusiasts to open this small and medium business by producing Fried Chicken fast food
Pemberdayaan Perempuan Korban Kekerasan Seksual
Authors: Rosjayani Annisa Pratiwi , Solahudin Dindin , Kurniawan Muh Idham
Published: June 2023

Sexual violence against women is a social problem that cannot be avoided. The policy of UPT PPA as a provider of protection services for women victims of sexual violence and empowerment carried out by UPT PPA Makassar is through training. This paper aims to identify forms of sexual violence against women, describe the implementation of women's empowerment for victims of sexual violence and measure the success rate of women's empowerment programs. This study uses a qualitative method with a descriptive approach, the data used in the form of empirical data and obtained through observations and interviews and accompanied by the results of documentation. The results showed that victims of sexual violence against women there were forms of violence, namely rape and sexual harassment. Therefore, the efforts made by UPT PPA Makassar help victims so that they gradually recover and improve psychologically. Victims of sexual violence after receiving recovery can be empowered with sewing training and show their identity as women and can change economic conditions so that women can empower themselves and be more independent.
Deep Learning TCP for Mitigating NLoS Impairments in 5G mmWave
Authors: Poorzare Reza , Calveras Anna
Published: June 2023

5G and beyond 5G are revolutionizing cellular and ubiquitous networks with new features and capabilities. The new millimeter-wave frequency band can provide high data rates for the new generations of mobile networks but suffers from NLoS caused by obstacles, which causes packet drops that mislead TCP because the protocol interprets all drops as an indication of network congestion. The principal flaw of TCP in such networks is that the root for packet drops is not distinguishable for TCP, and the protocol takes it for granted that all losses are due to congestion. This paper presents a new TCP based on deep learning that can outperform other common TCPs in terms of throughput, RTT, and congestion window fluctuation. The primary contribution of deep learning is providing the ability to distinguish various conditions in the network. The simulation results revealed that the proposed protocol could outperform conventional TCPs such as Cubic, NewReno, Highspeed, and BBR.
A deep reinforcement learning-based optimization method for long-running applications container deployment
Authors: Deng Lei , Wang Zhaoyang , Sun Haoyang , Li Bo , Yang Xiao
Published: June 2023

Unlike the short execution cycles of batch jobs, intelligent algorithmic applications typically run in long-cycle containers in the cloud(Long-Running Applications, LRA). Both need to meet strict SLO (service level objective) requirements, consider performance scaling to cope with peak load demands, and face issues such as I/O dependencies and resource contention and interference from coexisting containers. The above greatly complicates container deployment and can easily lead to performance bottlenecks. Therefore, the optimization of LRA-like container deployment is one of the key issues that cannot be avoided and needs to be addressed in the cloud computing model. This research uses deep reinforcement learning (DRL) to optimize the deployment of LRAs class containers. The proposed non-generic model is able to customize a dedicated model for each container group, providing high-quality placement and low training complexity; meanwhile, the proposed batch deployment scheme is able to optimize various scheduling objectives that are not directly supported by existing constraint-based schedulers, such as minimizing SLO violations. The experimental results show that the performance of the DRL deployment algorithm improves by 56.2% compared to the average RPS of the baseline, indicating that the manual deployment scheme can only meet the basic requirements but cannot cover the complex interactions between containers under constraints from a global perspective. This limitation severely limits the performance of the whole pod. Meanwhile, based on previous experience, the time consumption of a single deployment scheme is about 1 hour, while the time consumption of the DRL deployment algorithm may be less than 7.5 minutes.
FABRICATION OF REALISTIC TRANSPARENT POROUS MEDIA FOR 3D OBSERVATION OF INTERNAL MASS TRANSPORT
Authors: Gyotoku Taiki , Iwaguchi Tatsuki , Hanya Shigeto , Harada Shusaku , Tanaka Yohsuke , Yamamoto Yasufumi
Published: June 2023

A new experimental system was developed to observe the migration of colloidal particles in saturated porous media in 3D, which is important in engineering processes such as contaminant migration and filtration. The system enables the observation of internal migration that is invisible from the outside by fabricating a porous body using a transparent material and a 3D printer. Non-artificial media with arbitrarily controlled internal pore sizes were fabricated by designing the porous media based on the results of numerical analysis on phase-separation phenomena. The refractive indices of the porous media and the interstitial liquid were matched, and a laser sheet was used to extract cross sections of the media. By reconstructing multiple cross-sectional images, it was possible to visualize the 3D migration of suspended particles. The developed system was then applied to the collective gravitational settling of fine particles in saturated porous media. The results showed that the particles selectively settled in the pore networks while repeatedly branching in the lateral direction.
A BRIEF STUDY OF IMBIBITION PHENOMENON IN FLUID FLOW THROUGH STRONGLY-WET CRACKED POROUS MEDIA
Authors: Kesarwani Juhi
Published: June 2023

In this research, we constructed an analytical model to investigate the two-phase fluid flow during the forced and
spontaneous imbibition phenomenon in a water-wet cracked porous material. The major goal of our work is to demonstrate how the cracked porous medium and porous matrix behave differently in terms of the recovery process during the forced and spontaneous imbibition phenomenon. In addition, we investigate the impact of inclined planes, wettability, viscosity ratio, capillary pressure, and capillary pressure on the recovery process via the imbibition phenomenon in a water-wet cracked porous medium.
Linking park utilisation and place attachment: towards liveable neighbourhoods
Authors: Moulay Amine , Ujang Norsidah , Maulan Suhardi , Abu Bakar Nor Azlina , Ahmad Nobaya
Published: June 2023

This study investigates the impact of place attachment on park utilisation through interaction of residents. The correlation between attributes of place attachment (functional, emotional and social attachment) and social interaction (engagement patterns and levels of interaction) is tested within Malaysian neighbourhood parks. Findings are based on systematic field observation and a questionnaire survey carried out with 387 residents in three Malaysian neighbourhoods. The results demonstrate a strong correlation between attributes of place attachment and resident engagement with parks, thereby increasing the potential for social interactions. The level of functional attachment is strongly linked to both passive and active interactions. Hence, environmental planning researchers should further focus on the psychological attachment process of park users to provide more responsive and inclusive parks. As functional attachment was found to be the key for promoting park use and social interaction, this study argues that devoting further attention to functional needs of residents will help mitigate the issue of underutilised parks and enhance liveability of neighbourhoods. As the relationships between park utilisation and the influences of characteristics of place attachment remain poorly understood, providing insight on how to include attributes of place attachment in the design process of parks will enhance responsiveness of parks.
Introduction
Authors: Schneider Magnus Tessing , Wagner Meike
Published: June 2023

What can artists learn from theatre scholars when performing historical works on stage today? And what can theatre scholars learn from today’s artists when striving to understanding the works and practices of the past? How are we affected by attending performances in historic theatres? And how, aesthetically, do we experience the reconstruction of productions from the remote past? Through a combination of academic and artistic research, the following essays try to answer these questions, presenting a variety of angles on today’s performances in historic theatres and on today’s attempts to revive theatrical practices of the past.
Deliberative Qualities of Online Abortion Discourse: Incivility and Intolerance in the American and Irish Abortion Discussions on Twitter
Authors: Oh Dayei , Elayan Suzanne , Sykora Martin
Published: June 2023

This paper provides a big-data-scale assessment of the deliberative qualities of online abortion discussions on Twitter in the United States (2020) and Ireland (2018) by specifically focusing on two standards: civility and tolerance for constructive disagreements. Using diverse computational methods and classification, our regression analysis provides mixed evaluations. We find that incivility and intolerance are uncommon behaviours in American and Irish abortion discourse on Twitter, but we also find that these anti-deliberative behaviours are (a) generating more engagements and thereby distorting the overall discussion atmosphere; (b) largely coming from the pro-life tweets; (c) dominated by a small set of hyperactive participants; and that (d) intolerant users tend to communicate within homogeneous echo chambers. Our results indicate that it is crucial for online deliberation to curtail the capabilities of these superparticipants distorting and radicalising the overall online political discourse. By studying two national contexts, our results provide comparability of our findings and insights that can improve our understanding of other contentious and polarised issues more broadly.
Aspirin for primary prevention of cardiovascular events in patients with chronic kidney disease: an updated meta-analysis v1
Authors: Bellos Ioannis
Published: June 2023

The present meta-analysis aims to evaluate the role of aspirin for the primary prevention of cardiovascular disease among patients with chronic kidney disease. A systematic literature search will be conducted and all studies (randomized controlled trials and cohorts) evaluating the efficacy and safety of aspirin will be evaluated. The quality of evidence will be critically assessed following the GRADE approach,
High Efficiency Yeast Library Transformation v1
Authors: Bolognesi Benedetta
Published: June 2023

This is a protocol to achieve high-efficiency (10^6 transformants/replicate) when transforming yeast cells with mutational libraries.
Stochastic Modeling of the Epidemic Process Based On a Stage-Dependent Model with Non-Markov Constraints for Individuals
Authors: Pertsev N. , Topchii V. , Loginov K.
Published: June 2023

A continuous-discrete stochastic model of the epidemic process is presented. The model takes into account several stages of the development of an infectious disease, as well as the distributions of the durations of stay of individuals in these stages. The variables of the model are integer random variables that denote the quantity of individuals in cohorts, and sets of unique types of individuals that take into account the current state and history of stay of individuals in the stages of development of an infectious disease, distributions of durations of these stages are different from exponential or geometric. The results of an analytical and numerical research of the dynamics of the epidemic process are presented. The probabilities of infection eradication during a finite period of time are examined, depending on the numerical values of the infection spread coefficient and the distributions of the durations of the latent stage of the disease and the stage of preservation of immunity to infection.
QUALITY PERFORMANCE OF DURUM WHEAT (Triticum durum L.) GERMPLASM UNDER RAINFED AND IRRIGATED FIELD CONDITIONS
Authors: DEMİREL Ufuk , KÖKEN İbrahim , CALİSKAN Mehmet , ÖZKAN Hakan
Published: June 2023

Wheat is usually grown as a rainfed crop and no irrigation is applied in most production fields. This study was undertaken to evaluate the quality characteristics of durum wheat germplasm in under rainfed and irrigated field conditions during 2019-2020 and 2021-2022 growing seasons. The experiments were laid out in 12x12 alpha lattice block design with two replicates for rainfed and irrigated experiments. Grain protein content, starch content, wet gluten content and test weight were examined for 125 genotypes which consisted of fifty local cultivars, nineteen foreign cultivars used in Turkey, forty two gene bank landraces (ex situ) and fourteen local landraces (in situ). Supplemental irrigation resulted in a decrease in grain protein content and wet gluten content but an increase in starch content. Ex situ landraces (17.48%) and in situ landraces (16.62%) had higher grain protein content mean values under both rainfed and irrigated conditions. The correlation coefficient was 0.82 between grain protein content-wet gluten content whereas it was -0.77 and -0.65 between grain protein content-starch content and wet gluten content-starch content, respectively. The decrease in protein and gluten content in local and foreign cultivars was more dramatic in both years compared to landraces. Our results indicated that ex situ landraces have a great potential in terms of grain quality characteristics. The high genotypic diversity and improved quality characteristics in landraces provided extensive insights for future studies to improve crop quality in areas with limited irrigation opportunities.
Anishinaabe Law at the Margins: Treaty Law in Northern Ontario, Canada, as Colonial Expansion
Authors: Brown Tenille E.
Published: June 2023

In 1850, 17 years before the Dominion of Canada was created, colonial officers in representation of Her Majesty the Queen, concluded Treaty Numbers 60 and 61 with the Anishinaabe Nation of Northern Ontario. The Robinson Treaties—so named after William Benjamin Robinson, a government official—include land cessions made by the Anishinaabe communities in return for ongoing financial support and protection of hunting rights. The land areas included in the treaty are vast territories that surround two of Canada’s great lakes: Lake Superior and Lake Huron. These lands were important for colonial expansion as settlements began to move west across North America. The treaties promised increased annual annuity payments “if and when” the treaty territory produced profits that enabled “the Government of this Province, without incurring loss, to increase the annuity hereby secured to them.” This amount has not been increased in 150 years. This article reviews Restoule v. Canada, a recent Ontario decision brought by Anishinaabe Treaty beneficiaries who seek to affirm these treaty rights. A reading of the Robinson Treaties that implements the original treaty promise and increases annuity payments would be a hopeful outcome of the Restoule v. Canada decision for it would be the implementation of reconciliation. In addition, the Restoule decision has important insights to offer about how Indigenous law can guide modern‐day treaty interpretation just as it guided the adoption of the treaty in 1850. The Robinson Treaties are important for the implementation of treaty promises through Indigenous law and an opportunity to develop a Canada in which Indigenous peoples are true partners in the development and management of natural resources.
Indigenous Emancipation: The Fight Against Marginalisation, Criminalisation, and Oppression
Authors: O’Brien Grace , Pan Pey‐Chun , Sheikh Mustapha , Prideaux Simon
Published: June 2023

This thematic issue addresses the challenges faced by Indigenous peoples in protecting their rights and maintaining their unique cultures and ways of life. Despite residing on all continents and possessing distinct social, cultural, economic, and political characteristics, Indigenous peoples have historically faced oppression and violation of their rights. Measures to protect Indigenous rights are gradually being recognized by the international community, but ongoing issues such as illegal deforestation, mining, and land clearances continue to desecrate sacred sites and oppress Indigenous peoples. Indigenous women and youth are particularly vulnerable, facing higher levels of gender‐based violence and overrepresentation in judicial sentencing statistics. Land rights continue to be threatened by natural resource extraction, infrastructure projects, large‐scale agricultural expansion, and conservation orders. There is also a heightened risk of statelessness for Indigenous peoples whose traditional lands cross national borders, leading to displacement, attacks, killings, and criminalization.
Dear Reviewer n: An Open Letter on Academic Culture, Structural Racism, and the Place of Indigenous Knowledges, With a Question From One Indigenous Academic to the Decolonising Academics Who Are Not
Authors: Avery Scott
Published: June 2023

This is an open letter on academic culture, structural racism, and the place of Indigenous knowledges.
Wedding Rituals of Chernihiv Oblast as a Promising Direction for the Development of Festival Tourism in Domestic Open-air Museums and Rural Estates
Authors:   Taras Shevchenko national University of Kyiv, Bondarenko Kateryna , Kazmyrchuk Mariia ,   Taras Shevchenko national University of Kyiv
Published: June 2023

Today, there is a considerable amount of scientific literature, which states that festival tourism is a promising type of tourism. The largest places for holding ethnic-style festivals are open-air museums (open-air museums), as well as smaller, but quite popular among fans of traditional cultural ceremonies, rural estates. Among the rich program offers, native manors offer visitors the organization of wedding events with Ukrainian traditional rites to order, and, larger in scale, foreign and domestic scanens hold annual wedding festivals. Wedding festivals have gained special development in the Kyiv region. However, other regions of Ukraine also have a rich cultural wedding ritual, which can be used to create new interesting mass tourist events in open-air museums and rural estates. Among such regions is Chernihiv Oblast, which has a rich historical and cultural heritage, including a unique wedding ceremony. Conventionally, it can be divided into several stages – pre-wedding, wedding and post-wedding.The pre-wedding cycle includes rites related to the consent of young people and their families for marriage: matchmaking or engagements. The actual wedding ritual also contains many interesting elements, for example, baking a korovai and «cones» decorating a «vil’tse» (wedding tree decorated with ribbons). These traditions still followed in the village of Stavyske in Chernihiv Oblast, and the natives of this village willingly return there to perform wedding in the traditional style, as their ancestors once did. Using open-air museums and village estates in ethno-festival tourism of wedding traditions and ceremonies of Chernihiv Oblast can attract tourists, popularize the cultural heritage of the Ukrainian people, and contribute to the economic revival of Ukrainian villages.
Assessment of CLOs, PLOs, ILOs, SLOs: An academic programme for educational theatre as a model
Authors: Zaghloul H. S.
Published: June 2023

Introduction. Educational theatre combines integrated opportunities and forms of education using theatrical arts. It develops in students the ability to use their proactive experiences into absorbing and challenge social reality. The educational value of theatre and performing arts is widely recognised, leading to the integration of theater programmes into the curriculum of universities globally. These programmes are overseen by specialised departments, and universities have established resources for instruction and training.

   Aim. The present research aims to evaluate the educational outcomes of the Academic Programme for Educational Theatre at the Faculty of Specific Education at Mansoura University in Egypt to ensure that the graduates are ready for the changing conditions of the economy and the needs of the labour market. Concerning the same, the adoption of educational theatre as a model had not been evaluated in the country.

   Methodology and research methods. The current study finds the role of SLOs, CLOs, PLOs, and ILOs as measures to examine the impact of the educational theatre model. Using a mixed method with the survey of 50 students and interviews of 20 faculty members of the Academic Programme for Educational Theatre, the identification of educational theatre’s impact on the learning outcomes of students is determined.

   Results. The results show that academic educational programmes depend on the performing arts and the participation of the learner in vocal performance, acting, and movement, activate the learning process and make the educational environment more effectively and greatly improve the learning and practice process. The results also emphasised the significance of educational institutions, particularly universities, in adopting academic programmes that incorporate practical experience, training, hands-on activities, and utilising appropriate evaluation methods.

   Scientific novelty. These academic educational models help engage students to create a positive emotional state, drive curiosity, strive to excel, build national character, focus on social issues, and believe in their capabilities.

   Practical significance. Accreditation of academic programmes based on practice and training develops students psychologically and mentally and raises the level of academic achievement and professional and personal development. Therefore, the study recommended the adoption of educational theatre courses in Egypt to ensure that the students are prepared to adapt to the changes in the labour market.
Mutual Learning Community: Teachers’ Opinions about Their Learning Possibilities in Schools Implementing International Programmes
Authors: Rojek Marcin , Leek Joanna , Kosiorek Małgorzata , Dobińska Gabriela
Published: June 2023

The purpose of the study is to identify teachers’ opinions on their learning opportunities in schools implementing the following international programmes in Poland: International Baccalaureate (IB), Advanced Placement (AP), and International General Certificate of Secondary Education (IGCSE). The study was conducted using the diagnostic survey method on a group of 103 teachers. The theoretical basis was Wenger’s (1998) model of learning in communities of practice, which assumes that adult learning (in this case, teachers) can be analyzed in four areas: (1) Belonging, (2) Doing, (3) Becoming, and (4) Experiencing. Therefore, the socio-cultural situation of teachers and their common but specific educational practices conditioned by the specificity of international schools were adopted. The results show that teachers do not feel fully prepared to work after graduation, they use the knowledge and skills acquired in the workplace more often than that acquired during studies, and international programmes create favourable conditions for their learning and professional development. Teachers form a learning community at three levels: school, national, and international. Thus, they form a type of community of communities that Wenger calls a ‘constellation’.
Archaeological Implications of Koguryo’s Stone Chambered Tombs Excavated from the Central Korean Peninsula
Authors:   Korean Ancient Historical Society, Kang Hyunsook
Published: June 2023

Koguryo tomb is the empirical data that Koguryo occupied the central Korean Peninsula. The tomb of Koguryo's stone chamber excavated from the central Korean Peninsula, was left by Koguryo residents of the time. In that the central Korean Peninsula is the newly incorporated Koguryo territory, it was expected that stone chambered tombs hereand were possible other interpretation from Koguryo tombs in North Korea or northeastern China. So, this article tried to set the type of Koguryo stone chambered tombs in the central Korean Peninsula and find the archaeological implications inherent in the stone chambered tomb’s type. The types of Koguryo stone chambered tombs are divided based on the chamber planar plan and constructin skill. Since the rectangle tomb’s chamber was wide distribution in the central Korean Peninsula, it can be seen that information about the tomb’s chamber planr planar is shared among the inhabitants of the newly incorporated Koguryo realm. And the construction skill was divided into Koguryo style, localized Koguryo style, and non-Koguryo style, so it can be interpreted the difference of the groups that built tomb’s chambers. Therefore the diversity of tomb’s types suggests that the inhabitants of newly occupied Koguryo was diverse. From these, it can be seen that the spread of residents of Koguryo in the central Korean Peninsula took place in two steps proceeding. The first spread of southward took place between the end of the 4th century and the beginning of the 5th century, and the center of inhabitants was the Chuncheon area of the Bukhan River basin. The second was took place at the end of the 5th century following the invasion of Hanseong, and the descendants of the first Koguryo residents north of the Han River or the native incoporated Koguryo residents, spread along the Han River to various places. Therefore, judging from the aspects of Koguryo tomb’s types, the main bases of Koguryo's southern control can be said to be Chuncheon, Yongin in the southern inland of Gyeonggi-do, and Chungju in the Namhan River basin.
Hipertensión arterial renovascular en niños. Informe de tres casos
Authors: Gahona Villegas Junior R , Reyes Jurado Pamela , Ríos Méndez Raúl E
Published: June 2023

ANTECEDENTES: La hipertensión (HTA) renovascular es una patología poco frecuente en la edad pediátrica, existe compromiso del flujo sanguíneo renal por obstrucción de su arteria. La confirmación del diagnóstico se realiza mediante angiografía digital de substracción. La HTA debe ser controlada con terapia antihipertensiva. El tratamiento resolutivo es mediante angioplastia percutánea con balón o stent.
CASOS CLÍNICOS: Se presentan tres casos de niños de 1, 5 y 10 años con HTA a quienes se les realizó estudios de laboratorio e imagen no invasivos con resultados no concluyentes. Dada la alta sospecha de estenosis renal, se les realizó angiografía renal por cateterismo evidenciando estenosis de la arteria renal principal o de sus ramas, en el mismo acto se hizo angioplastia con balón en los 3 casos. Se logró disminuir y mantener la presión arterial inferior al p<95 sin medicación en dos de los casos. A los 3 años de seguimiento, solo uno de ellos mantiene medicación antihipertensiva y requiere nueva dilatación con balón y colocación de stent.
 
CONCLUSIONES: En esta serie los métodos de diagnóstico por imagen no invasivos no fueron concluyentes, informando solamente acerca de la asimetría renal. Niveles elevados de renina, aldosterona y alcalosis mixta generan alta sospecha para el diagnóstico. El tratamiento con IECA y ARA ll no tuvo repercusión en la función renal y podrían ser considerados como primera línea de tratamiento bajo monitoreo constante. La angiografía por cateterismo fue diagnóstica y terapéutica en el mismo acto.
 
PALABRAS CLAVE: hipertensión arterial, niños, estenosis arteria renal, angiografía renal, hiperreninemia