bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Walking Quality Variables between End-Stage Osteonecrosis of Femoral Head Patients and Healthy Subjects by a Footscan Plantar Pressure System
Authors: Wang Zehua , Mao Xingjia , Guo Zijian , Zhao Ruipeng , Feng Tengda , Xiang Chuan
Published: December 2022

Background and Objectives: Osteonecrosis of the femoral head (ONFH) is a progressive disease with a complex etiology and unknown pathogenesis. Gait analysis can objectively assess the functional behavior of the foot, thus revealing essential aspects and influencing factors of gait abnormalities. The aim of this study was to evaluate the differences in spatiotemporal parameters, static and dynamic plantar pressure parameters, and symmetry indices between patients with ONFH and healthy subjects. Materials and Methods: The study population consisted of 31 ONFH patients and 31 healthy volunteers. Gait parameters were obtained from the plantar pressure analysis system for both the ONFH and healthy groups. The symmetry index was calculated according to a formula, including spatiotemporal parameters, static and dynamic plantar pressure distribution, percentage of regional impulse, and percentage of the restricted contact area. Results: Compared with healthy controls, patients with ONFH had slower walking speed, shorter step length and stride length, and increased stride time, stance time, and percentage of stance. patients with ONFH had lower plantar static pressure on the affected side and higher contralateral plantar static pressure during stance than controls. During walking, the peak pressures in all regions on the affected side and the peak pressure in the toe 1 and metatarsal 3 regions on the healthy side were lower in ONFH patients than in controls. The percentage of contact area and regional impulse in the heel of both limbs were higher in ONFH patients than in the control group. The symmetry indexes of stride time, stance time, step length, maximum force, impulse and contacted area were significantly increased in ONFH patients compared to controls, with decreased symmetry. Conclusions: Osteonecrosis of the femoral head leads to characteristic changes in plantar pressure distribution. These changes may be interpreted as an attempt by patients with ONFH to reduce the load on the affected limb. Plantar pressure analysis may assist in the diagnosis of ONFH and can provide an objective quantitative indicator for the assessment of subsequent treatment outcomes.
Respiratory Failure during BIS-Guided Sedation in a Patient with Relapsing Polychondritis: A Case Report
Authors: Lee Jaesang , Moon Hosik , Hong Sungjin , Chon Jinyoung , Kwon Hyejin , Park Hunwoo , Lee Jiyung
Published: December 2022

Relapsing polychondritis (RP) is a rare autoimmune disorder that causes inflammation and deterioration of cartilaginous structures such as the ears, nose, joints and laryngotracheobronchial tree. A 42-year-old man receiving treatment for RP underwent open reduction and internal fixation of a femur fracture under spinal anesthesia and with sedation by propofol and remifentanil. The level of sedation was monitored via a bispectral index (BIS), and maintained at between 60 and 80. At the end of the operation, he lost consciousness and displayed weak respiratory effort. During mask ventilation, the patient was judged to have respiratory failure due to high end-tidal CO2 (EtCO2) concentration and respiratory acidosis in an arterial-blood-gas analysis (ABGA). Ventilation through a properly inserted laryngeal-mask-airway or endotracheal intubation were impossible; instead, a surgical tracheotomy was performed. After recovering from respiratory failure with ventilatory support in the intensive care unit (ICU), he experienced the same symptoms three more times, requiring ventilatory support. He was discharged with bilevel positive-airway-pressure (BiPAP), after successful adaptation.
Is There a Risk of Misinterpretation of Potassium Concentration from Undetectable Hemolysis Using a POCT Blood Gas Analyzer in the Emergency Department?
Authors: Nigro Marianna , Valli Gabriele , Marchionne Maria Luisa , Sattarinia Dario , Silvestrini Fabiana , De Pietro Daniele , Fazzini Simone , Roselli Giorgia , Spallino Andrea , Praticò Valentina , Mirante Enrico , Castaldo Ersilia , Pugliese Francesco Rocco , Cicchini Claudia , Ancona Carlo , De Marco Francesca , Ruggieri Maria Pia , Di Somma Salvatore
Published: December 2022

Background and Objectives: Hemolysis is reported to be present in up to 10% of blood gas specimens in the central lab; however, few data on the incidence of hemolysis using a point-of-care testing (POCT) blood gas analysis are available in the setting of the emergency department. The aims of this study were: (1) to analyze the prevalence of hemolysis in blood gas samples collected in the ED using a POCT device; and (2) to evaluate the impact of hemolysis on blood sample results and its clinical consequences. Materials and Methods: We collected 525 consecutive POCT arterial blood gas samples using syringes with electrolyte-balanced heparin within 3 different EDs in the metropolitan area of Rome. Immediately after the collection, the blood samples were checked for the presence of hemolysis with a POCT instrument (i.e., HEMCHECK, H-10 ®). The samples were then subsequently processed for blood gasses, and an electrolytes analysis by a second operator blinded for the hemolysis results. A venous blood sample was simultaneously collected, analyzed for it’s potassium value, and used as a reference. Results: Of the samples, 472 were considered for the statistics, while 53 were excluded due to the high percentage of hemolysis due to operator fault in carrying out the measurement. The final mean hemolysis per operator was 12% (±13% SD), and the total final hemolysis was 14.4%.Potassium (K+) was significantly higher in the hemolyzed group compared with the non-hemolyzed sample (4.60 ± 0.11 vs. 3.99 ± 0.03 mEq/L; p < 0.001), and there were differences between arterial potassium versus venous potassium (D(a-v) K+, 0.29 ± 0.06 vs.−0.19 ± 0.02 mEq/L, p < 0.01). A Bland–Altman analysis confirmed that hemolysis significantly overestimated blood potassium level. Conclusion: Almost 12% of POCT blood gas analysis samples performed in the ED could be hemolyzed, and the presence of this hemolysis is not routinely detected. This could cause an error in the interpretation of the results, leading to the consideration of potassium concentrations being below the lower limit within the normal limits and also leading to the diagnosis of false hyperkalemia, which would have potential clinical consequences in therapeutic decision-making in the ED. The routine use of a POCT hemolysis detector could help prevent any misdiagnoses.
Leadless Pacemaker Implantation in the Emergency Bradyarrhythmia Setting: Results from a Multicenter European Registry
Authors: Schiavone Marco , Filtz Annalisa , Gasperetti Alessio , Breitenstein Alexander , Palmisano Pietro , Mitacchione Gianfranco , Gulletta Simone , Chierchia Gian Battista , Montemerlo Elisabetta , Statuto Giovanni , Russo Giulia , Casella Michela , Vitali Francesco , Mazzone Patrizio , Hofer Daniel , Arabia Gianmarco , Tundo Fabrizio , Ruggiero Diego , Fierro Nicolai , Moltrasio Massimo , Bertini Matteo , Dello Russo Antonio , Pisanò Ennio C. L. , Della Bella Paolo , Rovaris Giovanni , de Asmundis Carlo , Biffi Mauro , Curnis Antonio , Tondo Claudio , Saguner Ardan M. , Forleo Giovanni B.
Published: December 2022

Background. Data on leadless pacemaker (LPM) implantation in an emergency setting are currently lacking. Objective. We aimed to investigate the feasibility of LPM implantation for emergency bradyarrhythmia, in patients referred for urgent PM implantation, in a large, multicenter, real-world cohort of LPM recipients. Methods. Two cohorts of LPM patients, stratified according to the LPM implantation scenario (patients admitted from the emergency department (ED+) vs. elective patients (ED−)) were retrieved from the iLEAPER registry. The primary outcome of the study was a comparison of the peri-procedural complications between the groups. The rates of peri-procedural characteristics (overall procedural and fluoroscopic duration) were deemed secondary outcomes. Results. A total of 1154 patients were enrolled in this project, with patients implanted due to an urgent bradyarrhythmia (ED+) representing 6.2% of the entire cohort. Slow atrial fibrillation and complete + advanced atrioventricular blocks were more frequent in the ED+ cohort (76.3% for ED+ vs. 49.7% for ED−, p = 0.025; 37.5% vs. 27.3%, p = 0.027, respectively). The overall procedural times were longer in the ED+ cohort (60 (45–80) mins vs. 50 (40–65) mins, p < 0.001), showing higher rates of temporary pacing (94.4% for ED+ vs. 28.9% for ED−, p < 0.001). Emergency LPM implantation was not correlated with an increase in the rate of major complications compared to the control group (6.9% ED+ vs. 4.2% ED−, p = 0.244). Conclusion. LPM implantation is a feasible procedure for the treatment of severe bradyarrhythmia in an urgent setting. Urgent LPM implantation was not correlated with an increase in the rate of major complications compared to the control group, but it was associated with longer procedural times.
A Deeper Insight into the Interfacial Behavior and Structural Properties of Mixed DPPC/POPC Monolayers: Implications for Respiratory Health
Authors: Geng Yingxue , Cao Yan , Li Yingjie , Zhao Qun , Liu Dan , Fan Ge , Tian Senlin
Published: December 2022

1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1-palmitoyl-2-oleyl-sn-glycerol-3-phosphorcholine (POPC) are important components in pulmonary surfactants (PSs), of which the relative content is related to lung compliance. Herein, the phase behavior and thermodynamic structure of mixed DPPC/POPC monolayers were studied to elucidate the intermolecular interaction between DPPC and POPC molecules. Surface pressure–molecular area isotherms demonstrated that POPC significantly affected the phase behavior of the lipid domain structure as a function of its concentration. The compression modulus of the mixed monolayers reduced with the increase in POPC proportion, which can be attributed to the intermolecular repulsion between DPPC and POPC. Brewster angle microscopy analysis showed that the ordered structure of the monolayers trended toward fluidization in the presence of POPC. Raman spectroscopy results revealed that the change in C–C skeleton stretching vibration was the main cause of the decrease in the monolayer packing density. These findings provide new insights into the role of different phospholipid components in the function of PS film at a molecular level, which can help us to understand the synergy effects of the proportional relationship between DPPC and POPC on the formation and progression of lung disease and provide some references for the synthesis of lung surfactants.
Interactions of Mycotoxin Alternariol with Cytochrome P450 Enzymes and OATP Transporters
Authors: Fliszár-Nyúl Eszter , Ungvári Orsolya , Dombi Ágnes , Özvegy-Laczka Csilla , Poór Miklós
Published: December 2022

Alternariol (AOH) is an emerging mycotoxin produced by Alternaria strains. The acute toxicity of the mycotoxin is low; however, chronic exposure to AOH may result in the development of endocrine disruptor and/or carcinogenic effects. The toxicokinetic properties of AOH have barely been characterized. Therefore, in this study, we aimed to investigate its interactions with CYP (1A2, 2C9, 2C19, 2D6, and 3A4) enzymes and OATP (1A2, 1B1, 1B3, and 2B1) transporters employing in vitro enzyme assays and OATP overexpressing cells, respectively. Our results demonstrated that AOH is a strong inhibitor of CYP1A2 (IC50 = 0.15 μM) and CYP2C9 (IC50 = 7.4 μM). Based on the AOH depletion assays in the presence of CYP enzymes, CYP1A2 is mainly involved, while CYP2C19 is moderately involved in the CYP-catalyzed biotransformation of the mycotoxin. AOH proved to be a strong inhibitor of each OATP transporter examined (IC50 = 1.9 to 5.4 μM). In addition, both direct and indirect assays suggest the involvement of OATP1B1 in the cellular uptake of the mycotoxin. These findings promote the deeper understanding of certain toxicokinetic interactions of AOH.
Curcumin and Vitamin C Attenuate Gentamicin-Induced Nephrotoxicity by Modulating Distinctive Reactive Species
Authors: Tomşa Anamaria Magdalena , Răchişan Andreea Liana , Pandrea Stanca Lucia , Benea Andreea , Uifălean Ana , Toma Corina , Popa Roxana , Pârvu Alina Elena , Junie Lia Monica
Published: December 2022

Gentamicin remains widely used in all age groups despite its well-documented nephrotoxicity; however, no adjuvant therapies have been established to counteract this side effect. Our study aimed to experimentally determine whether curcumin and vitamin C have nephroprotective effects and whether certain reactive species could be used as markers of early gentamicin nephrotoxicity. Wistar adult male rats were evenly distributed into four groups: control, gentamicin, curcumin and gentamicin, vitamin C and gentamicin (gentamicin: 60 mg/kg/day, intraperitoneally, 7 days). We determined renal function (urea, creatinine), oxidative stress (malondialdehyde, nitric oxide, 3-nitrotyrosine, total oxidative stress), and antioxidant and anti-inflammatory status (thiols, total antioxidant capacity, interleukin-10). Nephrotoxicity was successfully induced, as shown by the elevated creatinine levels in the gentamicin group. In contrast, supplementation with curcumin and vitamin C prevented an increase in urea levels while decreasing total oxidative stress levels compared to the gentamicin group. Moreover, vitamin C and curcumin distinctively modulate the levels of nitric oxide and malondialdehyde. Histological analysis showed more discrete lesions in rats that received vitamin C compared to the curcumin group.
“Silicon-On-Insulator”-Based Biosensor for the Detection of MicroRNA Markers of Ovarian Cancer
Authors: Ivanov Yuri D. , Kapustina Svetlana I. , Malsagova Kristina A. , Goldaeva Kristina V. , Pleshakova Tatyana O. , Galiullin Rafael A. , Shumov Ivan D. , Kozlov Andrey F. , Glukhov Alexander V. , Grabezhova Victoria K. , Popov Vladimir P. , Petrov Oleg F. , Ziborov Vadim S. , Kushlinskii Nikolay E. , Alferov Alexander A. , Konev Vladimir A. , Kovalev Oleg B. , Uchaikin Vasiliy F. , Archakov Alexander I.
Published: December 2022

Ovarian cancer is a gynecological cancer characterized by a high mortality rate and tumor heterogeneity. Its early detection and primary prophylaxis are difficult to perform. Detecting biomarkers for ovarian cancer plays a pivotal role in therapy effectiveness and affects patients’ survival. This study demonstrates the detection of microRNAs (miRNAs), which were reported to be associated with ovarian cancer tumorigenesis, with a nanowire biosensor based on silicon-on-insulator structures (SOI-NW biosensor). The advantages of the method proposed for miRNA detection using the SOI-NW biosensor are as follows: (1) no need for additional labeling or amplification reaction during sample preparation, and (2) real-time detection of target biomolecules. The detecting component of the biosensor is a chip with an array of 3 µm wide, 10 µm long silicon nanowires on its surface. The SOI-NW chip was fabricated using the “top-down” method, which is compatible with large-scale CMOS technology. Oligonucleotide probes (oDNA probes) carrying sequences complementary to the target miRNAs were covalently immobilized on the nanowire surface to ensure high-sensitivity biospecific sensing of the target biomolecules. The study involved two experimental series. Detection of model DNA oligonucleotides being synthetic analogs of the target miRNAs was carried out to assess the method’s sensitivity. The lowest concentration of the target oligonucleotides detectable in buffer solution was 1.1 × 10−16 M. In the second experimental series, detection of miRNAs (miRNA-21, miRNA-141, and miRNA-200a) isolated from blood plasma samples collected from patients having a verified diagnosis of ovarian cancer was performed. The results of our present study represent a step towards the development of novel highly sensitive diagnostic systems for the early revelation of ovarian cancer in women.
Numerical Study on the Evaporation of a Non-Spherical Sessile Droplet
Authors: Cui Wenbin , Cao Yang , Wang Shoupei , Zhang Tianci , Ma Hongbin , Chang Chao , Liang Dalong , Dong Jingming
Published: December 2022

To better understand the evaporation of a non-spherical droplet, a two-dimensional simulation was conducted to investigate the evaporation on the asymmetric cross-section of non-spherical sessile droplets, which are characterized by two curvatures with two different contact angles on both sides. The temperature distribution, internal flow, and evaporation flux distribution at a quasi-steady state were revealed to be different from the spherical droplets. When heated from the substrate, the lowest surface temperature moves to the side of higher curvature or larger contact angle, forming a single vortex in the droplet. This single-vortex formation continues to be enhanced by enlarging the contact angle discrepancy. Unlike spherical droplets, the smaller curvature side of a non-spherical sessile droplet will release more evaporation flux. In addition, it is found that the non-spherical sessile droplets could surpass the spherical sessile droplets in evaporation flux.
The Transformation of Hg2+ during Anaerobic S0 Reduction by an AMD Environmental Enrichment Culture
Authors: Zhou Yuhang , Liu Yue , Liu Hongchang , Nie Zhenyuan , Wang Yirong , Chen Lu
Published: December 2022

Mercury (Hg) is a highly toxic and persistent heavy metal pollutant. The acid mine drainage (AMD) environment in sulfide-mining areas is a typical Hg pollution source. In this paper, the transformation of Hg2+ during anaerobic S0 reduction by an AMD environmental enrichment culture was studied by multiple spectroscopic and microscopic techniques. The experimental results showed that the microbial S0 reduction of the AMD enrichment culture was significantly inhibited in the presence of Hg2+. The results of cell surface morphology and composition analysis showed that there was obvious aggregation of flocculent particles on the cell surface in the presence of Hg2+, and the components of extracellular polymeric substances on the cell surface changed significantly. The results of surface morphology and C/S/Hg speciation transformation analyses of the solid particulate showed that Hg2+ gradually transformed to mercuric sulfide and Hg0 under anaerobic S0 reduction by the AMD enrichment culture. The microbial community structure results showed that Hg2+ significantly changed the enrichment community structure by decreasing their evenness. The dominant microorganisms with S0 reduction functions are closely related to mercury transformation and are the key driving force for the transformation of substrate solid particulate and cellular substances, as well as the fixation of Hg2+.
A New Kayfunavirus-like Escherichia Phage vB_EcoP-Ro45lw with Antimicrobial Potential of Shiga Toxin-Producing Escherichia coli O45 Strain
Authors: Sun Xincheng , Liao Yen-Te , Zhang Yujie , Salvador Alexandra , Ho Kan-Ju , Wu Vivian C. H.
Published: December 2022

Lytic bacteriophages are re-considered as a solution to resolve antibiotic-resistant rampage. Despite frequent foodborne outbreaks caused by the top six non-O157 Shiga-toxin-producing Escherichia coli (STEC), the current interventions are not sufficiently effective against each serogroup, particularly O45. Therefore, this study aimed to characterize a new short-tailed phage, vB_EcoP-Ro45lw (or Ro45lw), as an alternative antimicrobial agent for STEC O45 strains. Phage Ro45lw belongs to the Kayfunavirus genus within the Autographiviridae family and shares no close evolutionary relationship with any reference phages. Ro45lw contains a tail structure composed of a unique tail fiber and tail tubular proteins A and B, likely to produce enzymatic activity against the target bacterial cells besides structural function. Additionally, the phage genome does not contain virulent, antibiotic-resistant, or lysogenic genes. The phage has a latent period of 15 min with an estimated burst size of 55 PFU/CFU and is stable at a wide range of pH (pH4 to pH11) and temperatures (30 °C to 60 °C). Regardless of the MOIs (MOI = 0.1, 1, and 10) used, Ro45lw has a strong antimicrobial activity against both environmental (E. coli O45:H-) and clinical (E. coli O45:H2) strains at 25 °C. These findings indicate that phage Ro45lw has antimicrobial potential in mitigating pathogenic STEC O45 strains.
Gram-Negative Endogenous Endophthalmitis: A Systematic Review
Authors: Tiecco Giorgio , Laurenda Davide , Mulè Alice , Arsuffi Stefania , Storti Samuele , Migliorati Manuela , Boldini Alessandro , Signorini Liana , Castelli Francesco , Quiros-Roldan Eugenia
Published: December 2022

Background: Gram-negative bacteria are causative agents of endogenous endophthalmitis (EBE). We aim to systematically review the current literature to assess the aetiologies, risk factors, and early ocular lesions in cases of Gram-negative EBE. Methods: All peer-reviewed articles between January 2002 and August 2022 regarding Gram-negative EBE were included. We conducted a literature search on PubMed and Cochrane Controlled Trials. Results: A total of 115 studies and 591 patients were included, prevalently Asian (98; 81.7%) and male (302; 62.9%). The most common comorbidity was diabetes (231; 55%). The main aetiologies were Klebsiella pneumoniae (510; 66.1%), Pseudomonas aeruginosa (111; 14.4%), and Escherichia coli (60; 7.8%). Liver abscesses (266; 54.5%) were the predominant source of infection. The most frequent ocular lesions were vitreal opacity (134; 49.6%) and hypopyon (95; 35.2%). Ceftriaxone (76; 30.9%), fluoroquinolones (14; 14.4%), and ceftazidime (213; 78.0%) were the most widely used as systemic, topical, and intravitreal anti-Gram-negative agents, respectively. The most reported surgical approaches were vitrectomy (130; 24.1%) and evisceration/exenteration (60; 11.1%). Frequently, visual acuity at discharge was no light perception (301; 55.2%). Conclusions: Gram-negative EBEs are associated with poor outcomes. Our systematic review is mainly based on case reports and case series with significant heterogeneity. The main strength is the large sample spanning over 20 years. Our findings underscore the importance of considering ocular involvement in Gram-negative infections.
Epidemiology of Fungal Periprosthetic Joint Infection: A Systematic Review of the Literature
Authors: Sambri Andrea , Zunarelli Renato , Fiore Michele , Bortoli Marta , Paolucci Azzurra , Filippini Matteo , Zamparini Eleonora , Tedeschi Sara , Viale Pierluigi , De Paolis Massimiliano
Published: December 2022

Fungal prosthetic joint infection (fPJI) is a rare complication; nonetheless, it represents a significant diagnostic and therapeutic challenge. There are no official guidelines on the most effective approach to identify and treat fPJIs. This systematic review aims to review the current literature on fPJI management and provide a comprehensive overview of this topic, especially from an epidemiologic point of view. Studies eligible for this systematic review were identified through an electronic systematic search of PubMed, Scopus, and Web of Science until 30 September 2022. Further references were obtained by cross-referencing. Sixty-three studies met the inclusion criteria, reporting on 372 cases of fPJI; such cases were described mostly in case reports and small case series with only a few larger cohort studies. Diagnosis of fPJI is challenging because of its chronic and indolent clinical course; it is further complicated by the technical difficulty of harvesting fungal cultures. A two-stage revision was the primary procedure in 239 (64.2%) patients whereas DAIR and one-stage approaches were reported in 30 (8.0%) and 18 (4.8 %) cases. In conclusion, our study highlights the heterogeneity of the reported treatments of fPJI, particularly in terms of medical management. With concern to a surgical approach, a two-stage revision arthroplasty is generally suggested, considering fPJI a delayed or late infection. The need for multicenter, prospective studies to provide standardized protocols and improve the treatment of fungal PJI clearly emerges.
Provenance of Ordovician Malieziken Group, Southwest Tarim and Its Implication on the Paleo-Position of Tarim Block in East Gondwana
Authors: Chang Zhe , Gao Zhiqian , Zhang Liangliang , Fan Tailiang , Wei Duan , Wang Jingbin
Published: December 2022

Tarim is inferred to have a close connection with East Gondwana during the Ordovician, but the position in East Gondwana remains controversial. In this study, we report 316 detrital zircons U-Pb data from three samples of Ordovician Malieziken Group sedimentary rocks, collected in the Qiate Section, Southwest Tarim, provided new insight into the position of Tarim in East Gondwana. Detrital zircons data indicated the maximum depositional age for the three samples is 489.5 Ma, 478.1 Ma, and 465 Ma, respectively, indicating the Qiate and Kandilike Formation of the Malieziken Group was deposited in Early—Middle Ordovician. The detrital zircons are characterized by two main peaks at ~490 Ma and ~1100 Ma, and three subordinate peaks at ~880 Ma, ~1400 Ma, and ~1650 Ma, suggesting most of the detritus of Malieziken Group from the South Kunlun Terrane (SKT) itself. However, the source of the ~1650 Ma peak is not found in the Tarim block, and the ~1400 Ma and the ~1650 Ma peak are absent in the middle of the three samples, which implied that there is an exotic source. The Paleoproterozoic sediment strata in the Albany–Fraser belt shows dominant peaks at ~1400 Ma and ~1650 Ma may have been transported to SKT and redeposited in the Malieziken Group during the Ordovician. The Malieziken Group shows detrital zircon age patterns resembling those of East Sumatra, Lhasa, and Western Australia which, in combination with the Albany–Fraser belt provenance, enables us to propose that the Tarim block has a close linkage with Western Australia, East Sumatra, and Lhasa in East Gondwana.
Detrital Zircon Geochronology and Tectonic Evolution Implication of the Middle Jurassic Zhiluo Formation, Southern Ordos Basin, China
Authors: Cui Liwei , Peng Nan , Liu Yongqing , Qiao Dawei , Liu Yanxue
Published: December 2022

The Ordos Basin’s southern part is a composite zone made up of numerous continental blocks and has long been influenced by surrounding tectonism. However, only a few studies have investigated the existence of southern provenance supply and the basin’s southern boundary in the Middle Jurassic Zhiluo Formation. Based on sandstone detrital zircon U-Pb dating and zircon rare earth element analyses, net-sand ratio maps, paleocurrent direction and the field outcrop survey, this study establishes the source area and boundary of the Zhiluo Formation in the southern basin, and discusses the tectonic events. The study shows that the four main age peaks in the detrital spectra occurs at 2283 Ma, 1788 Ma, 432.5 Ma and 218.7 Ma, with a few of the zircons dated at 794.5–1235.2 Ma. The North Qilian orogenic belt (N-QLOB), the western part of the North Qinling orogenic belt (NQOB), and the southern margin of the North China Block (SNCB) contributed to the provenance. According to an integrated analysis of the provenance and tectonic background of continental blocks in the basin’s southern margin, the boundary of the basin in the depositional period of the Zhiluo Formation should reach the N-QLOB in the southwest, the NQOB in the south, and the Sanmenxia–Lushan fault belt in the southeast. On the basis of the aforementioned findings, the tectonic evolution of the continental blocks at the southern periphery of the Ordos Basin was restored.
Editorial for Special Issue “Alkali Activated Cements and Concretes”
Authors: Kearsley Elsabé
Published: December 2022

Concrete consisting of sand, stone, water and Portland cement is the most widely used material in the construction of modern infrastructure [...]
A Study on the Imaging Method for the Channel Wave Dispersion Curve Variability Function
Authors: Wang Wei , Gao Xing , Wu Yanhui
Published: December 2022

When the channel wave passes through the abnormal body, the dispersion curve appears interval, dislocation, and discontinuity, resulting in the non-standard and large error of the “velocity-frequency” pickup result of the transmitted channel wave dispersion curve, which directly leads to the inaccurate tomography. Therefore, aiming at this problem, the imaging method of dispersion curve variability function is proposed: (1) count the breakpoints of dispersion curve according to three types; (2) set the weighting factor for the breakpoint according to the spectrum curve; (3) the variability function is constructed for the dispersion curve, and the corresponding variation value is obtained; and (4) the variability value is back projected into the imaging grid space to obtain the abnormal body information in the detection area. The example verification results show that the imaging results of this method are accurate and stable, and non-convergence is caused by cyclic iteration, which provides a new imaging mode for the detection of complex structures in coal seams.
Optimization of Photovoltaic Performance of Pb-Free Perovskite Solar Cells via Numerical Simulation
Authors: Alsalme Ali , Altowairqi Malak Faisal , Alhamed Afnan Abdullah , Khan Rais Ahmad
Published: December 2022

Recently, the simulation of perovskite solar cells (PSCs) via SCAPS-1D has been widely reported. In this study, we adopted SCAPS-1D as a simulation tool for the numerical simulation of lead-free (Pb-free) PSCs. We used methyl ammonium germanium iodide (MAGeI3) as a light absorber, zinc oxysulphide (ZnOS) as an electron transport layer (ETL), and spiro-OMeTAD as a hole transport layer. Further, the thickness of the ZnOS, MAGeI3, and spiro-OMeTAD layers was optimized. The optimal thicknesses of the ZnOS, MAGeI3, and spiro-OMeTAD layers were found to be 100 nm, 550 nm, and 100 nm, respectively. The optimized MAGeI3-based PSCs exhibited excellent power conversion efficiency (PCE) of 21.62%, fill factor (FF) of 84.05%, and Jsc of 14.51 mA/cm2. A fantastic open circuit voltage of 1.77 V was also obtained using SCAPS-1D. We believe that these theoretically optimized parameters and conditions may help improve the experimental efficiency of MAGeI3-based PSCs in the future.
Structural and Electrochemical Properties of Li2O-V2O5-B2O3-Bi2O3 Glass and Glass-Ceramic Cathodes for Lithium-Ion Batteries
Authors: Chen Yuan , Zhao Yufei , Liu Feihong , Ding Mengdie , Wang Juan , Jiang Jiuxin , Boulet Pascal , Record Marie-Christine
Published: December 2022

In this study, 20Li2O-60V2O5-(20 − x)B2O3-xBi2O3 (x = 5, 7.5, 10 mol%) glass materials have been prepared by the melt-quenching method, and the structure and morphology of the glass materials have been characterized by XRD, FTIR, Raman, and FE-SEM. The results show that the disordered network of the glass is mainly composed of structural motifs, such as VO4, BO3, BiO3, and BiO6. The electrochemical properties of the glass cathode material have been investigated by the galvanostatic charge-discharge method and cyclic voltammetry, and the results show that with the increases of Bi2O3 molar content, the amount of the VO4 group increases, and the network structure of the glass becomes more stable. To further enhance the electrochemical properties, glass-ceramic materials have been obtained by heat treatment, and the effect of the heat treatment temperature on the structure and electrochemical properties of the glass has been studied. The results show that the initial discharge capacity of the glass-ceramic cathode obtained by heat treatment at 280 °C at a current density of 50 mA·g−1 is 333.4 mAh·g−1. In addition, after several cycles of charging and discharging at a high current density of 1000 mA·g−1 and then 10 cycles at 50 mA·g−1, its discharge capacity remains at approximately 300 mAh·g−1 with a capacity retention rate of approximately 90.0%. The results indicate that a proper heat treatment temperature is crucial to improving the electrochemical properties of glass materials. This study provides an approach for the development of new glass cathode materials for lithium-ion batteries.
Evaluation of Genotoxicity and Toxicity of Annona muricata L. Seeds and In Silico Studies
Authors: Ferreira Gleison Gonçalves , Quaresma Ana Carolina Sousa , Brandão Dayse Lúcia do Nascimento , Marinho Andrey Moacir do Rosario , Siqueira José Edson de Sousa , Correa Kamila Leal , Silva-Júnior José Otávio Carréra , Percario Sandro , Dolabela Maria Fâni
Published: December 2022

Cancer is a multifactorial organic dysfunction for which great efforts are being devoted in searching for new treatments and therapeutic adjuvants. Annona muricata is a fruit that has promising activity against several types of cancer, as it contains acetogenins, the metabolite group associated with this action. Thus, the objective of this study was to evaluate, in experimental models, the toxic behavior of an extract and fraction rich in acetogenins from A. muricata seeds and study the acetogenin, Annonacin, in silico. Phytochemical characterization was made by thin layer chromatography, spectroscopy in the infrared region and nuclear magnetic resonance. Toxicity was evaluated by tests of Allium cepa and Artemia salina, and in silico studies using the SwissDock servers DockThor, PharmMapper, ADMETLab, PreADME, Osiris and ProTox. The extract and fraction showed genotoxic activity against meristematic cells of A. cepa, reducing the mitotic index; however, the extract produced great deleterious effects on the system, even causing cell necrosis. In A. Saline, the extract was more toxic than the fraction, but both samples were considered toxic. Annonacin was effectively linked to complex I, and presented different activities regarding toxicity. Thus, the results of this study are promising, highlighting the anticancer potential of acetogenins.
Planar Elongated B12 Structure in M3B12 Clusters (M = Cu-Au)
Authors: Solar-Encinas José , Vásquez-Espinal Alejandro , Leyva-Parra Luis , Yañez Osvaldo , Inostroza Diego , Valenzuela Maria Luisa , Orellana Walter , Tiznado William
Published: December 2022

Here, it is shown that the M3B12 (M = Cu-Au) clusters’ global minima consist of an elongated planar B12 fragment connected by an in-plane linear M3 fragment. This result is striking since this B12 planar structure is not favored in the bare cluster, nor when one or two metals are added. The minimum energy structures were revealed by screening the potential energy surface using genetic algorithms and density functional theory calculations. Chemical bonding analysis shows that the strong electrostatic interactions with the metal compensate for the high energy spent in the M3 and B12 fragment distortion. Furthermore, metals participate in the delocalized π-bonds, which infers an aromatic character to these species.
Antimicrobial Activities Evaluation and Phytochemical Screening of Some Selected Plant Materials Used in Traditional Medicine
Authors: Stuper-Szablewska Kinga , Szablewski Tomasz , Przybylska-Balcerek Anna , Szwajkowska-Michałek Lidia , Krzyżaniak Michał , Świerk Dariusz , Cegielska-Radziejewska Renata , Krejpcio Zbigniew
Published: December 2022

Plant extracts are a source of valuable ingredients that can be used in many industries. This paper presents research on the content of selected bioactive compounds in extracts obtained from various plant materials. Raw materials have a documented use in traditional medicine not only in Poland. The tested plants were: bitter melon (fruit), elderberry (flowers, fruit, leaves), wild rose (fruit, flesh, seeds), mountain ash (fruit), guelder rose (fruit), and sea buckthorn (fruit, leaves, pomace). The main goal of these tests is to indicate the potential raw materials that may constitute an alternative source of bioactive compounds with antimicrobial activity. The plant material was tested for the content of bioactive antioxidant compounds and possible antimicrobial activity. The content of polyphenols (phenolic acids and flavonoids) was analyzed using UPLC/PDA, sterols, organic acids, and other bioactive compounds. The minimum inhibitory concentration (MIC) was determined. The total free phenolic acids (TPC) and total free flavonoids (TFC) of all plant raw materials was varied and ranged from 0.21 (mg RUTE/1 g of extract) to 38.30 mg RUTE/1 g of extract) for TFC. The concentration of sterols was, on average, about 10 mg/1 g of extract. The value of approx. 20 mg/1 g of the extract was recorded for bitter melon and beach rose. The content of organic acids was about 1.5 mg/1 g of the extract to even 13 mg/1 g of the extract for sea buckthorn berries. The most sensitive to the extracts’ activity were the following bacteria: M. luteus, P. mirabilis, P. fragii, S. enteritidis, and E. coli. The tested plant materials can be used in various industries as a source of bioactive compounds of an antibacterial nature.
Achieving Cycling Stability in Anode of Lithium-Ion Batteries with Silicon-Embedded Titanium Oxynitride Microsphere
Authors: Wang Sung Eun , Kim DoHoon , Kim Min Ji , Kim Jung Hyun , Kang Yun Chan , Roh Kwang Chul , Choi Junghyun , Lee Hyung Woo , Jung Dae Soo
Published: December 2022

Surface coating approaches for silicon (Si) have demonstrated potential for use as anodes in lithium-ion batteries (LIBs) to address the large volume change and low conductivity of Si. However, the practical application of these approaches remains a challenge because they do not effectively accommodate the pulverization of Si during cycling or require complex processes. Herein, Si-embedded titanium oxynitride (Si-TiON) was proposed and successfully fabricated using a spray-drying process. TiON can be uniformly coated on the Si surface via self-assembly, which can enhance the Si utilization and electrode stability. This is because TiON exhibits high mechanical strength and electrical conductivity, allowing it to act as a rigid and electrically conductive matrix. As a result, the Si-TiON electrodes delivered an initial reversible capacity of 1663 mA h g−1 with remarkably enhanced capacity retention and rate performance.
Evaporation Caused Invaginations of Acoustically Levitated Colloidal Droplets
Authors: Chen Hongyue , Zhang Yongjian , Wang Heyi , Dong Xin , Zang Duyang
Published: December 2022

Controlled buckling of colloidal droplets via acoustic levitation plays an important role in pharmaceutical, coating, and material self-assembly. In this study, the evaporation process of PTFE colloidal droplets with two particle concentrations (60 wt% and 20 wt%) was investigated under acoustic levitation. We report the occurrence of surface invagination caused by evaporation. For the high particle concentration droplet, the upper surface was invaginated, eventually forming a bowl-shaped structure. While for the low particle concentration droplet, both the upper and lower surfaces of the droplet were invaginated, resulting in a doughnut-like structure. For the acoustically levitated oblate spherical droplet, the dispersant loss at the equatorial area of the droplet is greater than that at the two poles. Therefore, the thickness of the solid shell on the surface of the droplet was not uniform, resulting in invagination at the weaker pole area. Moreover, once the droplet surface was buckling, the hollow cavity on the droplet surface would absorb the sound energy and results in strong positive acoustic radiation pressure at bottom of the invagination, thus further prompting the invagination process.
From Solid-State Cluster Compounds to Functional PMMA-Based Composites with UV and NIR Blocking Properties, and Tuned Hues
Authors: Amela-Cortes Maria , Wilmet Maxence , Le Person Samuel , Khlifi Soumaya , Lebastard Clément , Molard Yann , Cordier Stéphane
Published: December 2022

New nanocomposite materials with UV-NIR blocking properties and hues ranging from green to brown were prepared by integrating inorganic tantalum octahedral cluster building blocks prepared via solid-state chemistry in a PMMA matrix. After the synthesis by the solid-state chemical reaction of the K4[{Ta6Bri12}Bra6] ternary halide, built-up from [{Ta6Bri12}Bra6]4− anionic building blocks, and potassium cations, the potassium cations were replaced by functional organic cations (Kat+) bearing a methacrylate function. The resulting intermediate, (Kat)2[{Ta6Bri12}Bra6], was then incorporated homogeneously by copolymerization with MMA into transparent PMMA matrices to form a brown transparent hybrid composite Ta@PMMAbrown. The color of the composites was tuned by controlling the charge and consequently the oxidation state of the cluster building block. Ta@PMMAgreen was obtained through the two-electron reduction of the [{Ta6Bri12}Bra6]2− building blocks from Ta@PMMAbrown in solution. Indeed, the control of the oxidation state of the Ta6 cluster inorganic building blocks occurred inside the copolymer, which not only allowed the tuning of the optical properties of the composite in the visible region but also allowed the tuning of its UV and NIR blocking properties.
Novel Therapeutic Nutrients Molecules That Protect against Zika Virus Infection with a Special Note on Palmitoleate
Authors: Muthuraj Philma Glora , Krishnamoorthy Chandan , Anderson-Berry Ann , Hanson Corrine , Natarajan Sathish Kumar
Published: December 2022

Zika virus (ZIKV) is a Flavivirus from the Flaviviridae family and a positive-sense single strand RNA virus. ZIKV infection can cause a mild infection to the mother but can be vertically transmitted to the developing fetus, causing congenital anomalies. The prevalence of ZIKV infections was relatively insignificant with sporadic outbreaks in the Asian and African continents until 2006. However, recent epidemic in the Caribbean showed significant increased incidence of Congenital Zika Syndrome. ZIKV infection results in placental pathology which plays a crucial role in disease transmission from mother to fetus. Currently, there is no Food and Drug Administration (FDA) approved vaccine or therapeutic drug against ZIKV. This review article summarizes the recent advances on ZIKV transmission and diagnosis and reviews nutraceuticals which can protect against the ZIKV infection. Further, we have reviewed recent advances related to the novel therapeutic nutrient molecules that have been shown to possess activity against Zika virus infected cells. We also review the mechanism of ZIKV-induced endoplasmic reticulum and apoptosis and the protective role of palmitoleate (nutrient molecule) against ZIKV-induced ER stress and apoptosis in the placental trophoblasts.
Interaction of Passive Smoking and Diet Habits on Vitamin D Deficiency among Women of Reproductive Age in Rural Central China
Authors: Zhang Yuan , Lin Shiqi , Li Jiajia , Song Xinming , Chen Gong , Pei Lijun
Published: December 2022

Objective: Maternal dietary undernutrition is known to be associated with the risk of vitamin D (VD) deficiency. However, whether the risk of VD deficiency in women of reproductive age is influenced by the interaction between passive smoking and inadequate nutrition remains unknown. The aim of this study is to explore the interaction between passive smoking and dietary undernutrition on the risk of VD deficiency. Methods: A population-based case–control study including 1151 non-pregnant women of reproductive age between 18 and 40 years old was conducted in Henan Province, China from 2009 to 2010. Blood samples and information on exposure factors were collected. The prevalence of VD deficiency was estimated based on a result of serum 25-hydroxyvitamin D [25(OH)D] < 26.0 ng/mL. A multivariate logistic regression analysis was performed to explore the risk of VD deficiency. Results: The prevalence of VD deficiency was 61.5%. After adjusting for potential confounding factors, the interactions between passive smoking and no nutritional supplementation, passive smoking and insufficient egg intake, and passive smoking and insufficient milk dairy products intake were associated with the risk of VD deficiency, and the adjusted ORs were 3.40 (95% CI 2.26–5.13), 2.87 (95% CI 2.20–4.10), and 2.18 (95% CI 1.33–3.58), respectively. The interaction coefficients were calculated to be 2.35, 2.79, and 1.70, respectively, indicating there were significant interaction effects, as all of the coefficients were higher than 1. Conclusions: Our findings present that the risk of VD deficiency was potentially influenced by interactions between passive smoking and inadequate nutrition. Passive smoking might strengthen the effect of inadequate nutrition on the risk of VD deficiency among rural women of reproductive age. More attention should be paid to the health education and nutritional status improvement of women of reproductive age, especially in rural areas of developing countries.
L-Theanine Regulates the Abundance of Amino Acid Transporters in Mice Duodenum and Jejunum via the mTOR Signaling Pathway
Authors: Liu Kehong , Peng Yingqi , Lin Ling , Gong Zhihua , Xiao Wenjun , Li Yinhua
Published: December 2022

The intestine is a key organ for the absorption of amino acids. L-theanine (LTA) is a structural analog of glutamine and a characteristic non-protein amino acid found in tea (Camellia sinensis) that regulates lipid and protein metabolism. The present study explored the role of LTA in intestinal amino acid absorption, protein synthesis, and its mechanisms. Overall, our findings suggest that LTA supplementation not only affects serum alkaline phosphatase (AKP), total protein (TP), and urea nitrogen (BUN) levels, but it also upregulates the mRNA and protein expression of amino acid transporters (EAAT3, EAAT1, 4F2hc, y+LAT1, CAT1, ASCT2, and B0AT1), and activates the mTOR signaling pathway. The downstream S6 and S6K1 proteins are regulated, and the expression of amino acid transporters is regulated. These findings suggest that LTA increases intestinal AA absorption, promotes protein metabolism, and increases nitrogen utilization by upregulating AAT expression, activating the mTOR signaling pathway, and phosphorylating the mTOR downstream proteins S6 and S6K1.
Analysis of Global Search and Research Interests on Dentists Using Infoveillance and Bibliometric Approaches
Authors: Kanmodi Kehinde , Abolade Oluwafemi , Amzat Jimoh , Nnyanzi Lawrence
Published: December 2022

About half of the world’s population requires the services of a dentist. However, the in-depth understanding of the concerns and priorities of the global public and scientific communities concerning dentists is essential for the planning and development of sustainable strategies, interventions, and policies that will cater for the current global oral health needs. Therefore, this study investigated the global search and research interests on dentists using a hybrid research design—a combination of infoveillance and bibliometric research designs. The data analysed in this study were obtained from Google Trends and SCOPUS. The findings show that, over the years, there has been a significant growth in the volume of information search and research outputs on dentists with huge inequalities existing between the Global South and North. It is also notable that the COVID-19 pandemic played a significantly influential role in the global information search and dissemination trends on dentists. The knowledge and funding for dentist-related research flow significantly from the countries of the Global North. The review of the network visualisation of keyword co-occurrence revealed a misplaced priority in the global research interest areas on dentists and oral health. The obtained findings could help to shape the future of dental healthcare and policy.