bluuebunny/crossref_metadata_2025 huggingface dataset:
A Salutogenic Approach to Understanding the Potential of Green Programs for the Rehabilitation of Young Employees With Burnout: Protocol for a Mixed Method Study on Effectiveness and Effective Elements
Authors: Pijpker Roald , Vaandrager Lenneke , Veen Esther J , Koelen Maria A
Published: October 2019

Background

Burnout is the leading cause of absenteeism in the Netherlands, with associated sick leave costs amounting to around €1.8 billion. Studies have indicated that burnout complaints increased from almost 14.4% in 2014 to 17.3% in 2018, especially among employees between the ages of 18 and 35 years, and further increases are expected. Although there are many published articles on burnout, not much is known about what constitutes effective rehabilitation (ie, the reduction of burnout complaints and the facilitation of returning to work). At the same time, multiple pilot studies have indicated that green programs are effective in both reducing burnout complaints and facilitating return to work. Green programs have been developed by professionals experienced in using the natural environment to facilitate rehabilitation (eg, through green exercise and healing gardens). The literature nevertheless lacks comprehensive and contextual insight into what works and why.

Objective

The overarching aim of this study is to explore the potential of green programs for young employees with burnout. We present the study protocol from an ongoing research project consisting of 2 phases, each composed of 2 research objectives that sequentially build upon each other.

Methods

The study is based on a sequential design with 4 research objectives, using both qualitative and quantitative research methods. In the first phase, a systematic literature review (research objective 1) and in-depth interviews (research objective 2) will be used to explore mechanisms underlying the rehabilitation of young employees with burnout. In the second phase, a multicase study will be conducted to examine the extent to which green programs are built on mechanisms identified in the first phase (research objective 3). By employing a pretest and posttest design, a specific green program that captures most of those mechanisms will then be evaluated on its effect and process with regard to the rehabilitation of young employees with burnout (research objective 4). The project started in June 2018 and will continue through June 2022.

Results

The first phase (research objectives 1 and 2) is intended to generate information on the mechanisms underlying the rehabilitation of young employees with burnout. The second phase (research objectives 3 and 4) is designed to demonstrate the extent to which and how the selected green program facilitates the rehabilitation of young employees with burnout.

Conclusions

Understanding how green programs can facilitate the rehabilitation of young employees with burnout complaints can help to address this societal issue.

International Registered Report Identifier (IRRID)

DERR1-10.2196/15303
Effect of Online Health Information Seeking on Anxiety in Hospitalized Pregnant Women: Cohort Study (Preprint)
Authors: Coglianese Fabiana , Beltrame Vriz Giulia , Soriani Nicola , Piras Gianluca Niccolò , Comoretto Rosanna Irene , Clemente Laura , Fasan Jessica , Cristiano Lucia , Schiavinato Valentina , Adamo Valter , Marchesoni Diego , Gregori Dario
Published: October 2019

BACKGROUND

There are approximately 1,000,000 pregnant women at high risk for obstetric complications per year, more than half of whom require hospitalization.

OBJECTIVE

The aim of this study was to determine the relation between online health information seeking and anxiety levels in a sample of hospitalized woman with pregnancy-related complications.

METHODS

A sample of 105 pregnant women hospitalized in northern Italy, all with an obstetric complication diagnosis, completed different questionnaires: Use of Internet Health-information (UIH) questionnaire about use of the internet, EuroQOL 5 dimensions (EQ-5D) questionnaire on quality of life, State-Trait Anxiety Inventory (STAI) questionnaire measuring general anxiety levels, and a questionnaire about critical events occurring during hospitalization.

RESULTS

Overall, 98/105 (93.3%) of the women used the internet at home to obtain nonspecific information about health in general and 95/105 (90.5%) of the women used the internet to specifically search for information related to their obstetric disease. Online health information-seeking behavior substantially decreased the self-reported anxiety levels (P=.008).

CONCLUSIONS

Web browsing for health information was associated with anxiety reduction, suggesting that the internet can be a useful instrument in supporting professional intervention to control and possibly reduce discomfort and anxiety for women during complicated pregnancies.
24-Month Outcomes of Primary Care Web-Based Depression Prevention Intervention in Adolescents: Randomized Clinical Trial (Preprint)
Authors: Van Voorhees Benjamin , Gladstone Tracy R G , Sobowale Kunmi , Brown C Hendricks , Aaby David A , Terrizzi Daniela A , Canel Jason , Ching Eumene , Berry Anita D , Cantorna James , Eder Milton , Beardslee William , Fitzgibbon Marian , Marko-Holguin Monika , Schiffer Linda , Lee Miae , de Forest Sarah A , Sykes Emily E , Suor Jennifer H , Crawford Theodore J , Burkhouse Katie L , Goodwin Brady C , Bell Carl
Published: October 2019

BACKGROUND

Adolescent depression carries a high burden of disease worldwide, but access to care for this population is limited. Prevention is one solution to curtail the negative consequences of adolescent depression. Internet interventions to prevent adolescent depression can overcome barriers to access, but few studies examine long-term outcomes.

OBJECTIVE

This study compares CATCH-IT (Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training), an internet-based intervention, to a general health education active control for depression onset at 12 and 24 months in adolescents presenting to primary care settings.

METHODS

A 2-site randomized trial, blinded to the principal investigators and assessors, was conducted comparing Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training to health education to prevent depressive episodes in 369 adolescents (193 youths were randomly assigned to Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training and 176 to health education) with subthreshold depressive symptoms or prior depressive episodes. Participants were recruited from primary care settings in the United States. The primary outcome was the occurrence of a depressive episode, determined by the Depression Symptom Rating. The secondary outcome was functioning, measured by the Global Assessment Scale.

RESULTS

In intention-to-treat analyses, the adjusted hazard ratio favoring Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training for first depressive episode was not statistically significant at 12 months (hazard ratio 0.77, 95% CI 0.42-1.40, P=.39) and 24 months (hazard ratio 0.87, 95% CI 0.52-1.47, P=.61). Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training provided preventive benefit for first depressive episode for those with mild hopelessness or at least moderate paternal monitoring at baseline. Global Assessment Scale scores improved comparably in both groups (intention-to-treat).

CONCLUSIONS

A technology-based intervention for adolescent depression prevention implemented in primary care did not have additional benefit at 12 or 24 months. Further research is necessary to determine whether internet interventions have long-term benefit.

CLINICALTRIAL

ClinicalTrials.gov NCT01893749; http://clinicaltrials.gov/ct2/show/NCT01893749.
Removing Ethylene by Adsorption using Cobalt Oxide-Loaded Nanoporous Carbon
Authors: Prasetyo Imam , Mukti Nur Indah Fajar , Fahrurrozi Moh , Ariyanto Teguh
Published: October 2019

Ethylene is naturally generated by climacteric fruits and can promote the ripening process faster. For effective long-distance transport and subsequent storage, removing ethylene from the storage environment has been of interest to suppress its undesirable effect. In this study, ethylene removal by an adsorptive method using cobalt-loaded nanoporous carbon is studied. Cobalt oxide-loaded carbon was prepared by incipient wetness method followed by calcination process at 200 °C under inert flow. Ethylene adsorption test was performed at 20, 30, and 40 °C using a static volumetric test. The results showed that cobalt oxide/carbon system has significant ethylene adsorption capacity up to 3.5 times higher compared to blank carbon. A higher temperature adsorption is more favorable for this chemisorption process. Ethylene uptake increases from 100 to 150 mL g-1adsorbent STP by increasing cobalt oxide loading on carbon from 10 to 30 wt.% Co. The highest uptake capacity of 6 mmol ethylene per gram adsorbent was obtained using 30 wt.% cobalt oxide. Therefore, ethylene adsorption by cobalt-loaded nanoporous carbon may represent a potential method in ethylene removal and it could serve as a basis for development of ethylene scavenging material.
Comparison of Thermal Properties of PCB Photoresist Films Cured by Different Techniques
Authors: Wattanachai Piyachat , Antonio Christian , Roces Susan
Published: October 2019

The possibility of implementing microwave technology to photoresist film curing which is a major process in the production of electronic printed circuit boards (PCB) was investigated and compared with a conventional curing method, e.g. UV lithography. Since both techniques involved irradiation, hot plate curing which relies on thermal conduction was undertaken to study the effect of a heat transfer approach. Two film thicknesses were studied, i.e. 0.0012 and 0.002 inch, and the effects of curing power and time were investigated. Thermal properties, i.e. percent cure, glass transition temperature (Tg), composition and degradation temperature (Td), were evaluated using a Differential Scanning Calorimeter (DSC) and Thermogravimetric Analysis (TGA) and it was found that the commercial UV irradiation was sufficient to completely cure the thin film but only reached 76% cure for the thicker film, resulting in a lower Tg. The results show that the required processing conditions using a conventional household microwave to obtain almost complete curing were 1,000 Watts and 10 minutes curing time. In addition, improved curing was achieved in the thicker film because microwave can transmit into polar materials whereas UV cannot penetrate very far into the material. The hot plate curing was observed to produce a higher degree of curing and Tg, however, the uniformity of heating was found to be a major limiting factor of this technique. Slight differences in decomposition profiles of the films cured by different techniques implied slight differences in molecular structures. Compared to UV and hot plate curing, microwave technology was demonstrated as a potential curing technique in the production of PCBs due to its ability to efficiently cure thick films resulting in a strong material with high Tg. To apply the technique to other processes, optimal conditions, i.e. power and time, should be further investigated as well as the prevention of hot spots.
Use of a Novel Algorithm to Determine Cyclic Steady State
Authors: Razon Luis E
Published: October 2019

A simple algorithm originally proposed by Choong, Paterson and Scott (2002) was tested on a model of an isothermal controlled-cycled stirred tank reactor with substrate inhibition kinetics, (r = 1 ~c). In previous work, this reacting system had been shown to exhibit steady-state multiplicity. The transition period of this system to the stable steady state is sometimes characterized by very slow change followed by a very rapid convergence to the stable steady state. Tests of the Choong-Paterson-Scott algorithm showed that the feature, which prevents premature termination of the calculations prior to reaching the true steady state, is very useful for this system. However, tests of the stopping criterion showed that the other feature of reducing the computing time was not realized in this system.
Приемные устройства для ВОЛС: способы приема и обработки сигналов различных типов
Authors: Варава Н. , Пронин С. , Никаноров Н.
Published: October 2019

При работе волоконно-оптических линий связи с сигналами определенной формы требуется согласование приемных и передающих модулей по динамическому диапазону оптических сигналов, рабочей длине волны, типам волокна и оптических разъемов. Чтобы удовлетворить столь многообразные требования к ВОЛС для эксплуатации в условиях климатических, механических и электромагнитных воздействий разработаны комплекты функционально законченных модулей. Представлены оптические приемные устройства для различных применений, в том числе – для систем управления и запуска устройств, коммутирующих значительные мощности.
Александр Степанович Попов – триумф и трагедия ученого. Часть 1.
Authors: Борисова Н.
Published: October 2019

В связи с 160-летием со дня рождения изобретателя радио в Центральном музее связи им. А.С.Попова в марте-апреле 2019 года работала выставка "Триумф и трагедия ученого". Александр Степанович Попов не увидел своего триумфа по-настоящему, а трагические коллизии начала 20 века, особенно 1905 года, закончились для него преждевременным уходом из жизни.
Iskratel: от координатного искателя до безопасного города.
Authors: Попов С.
Published: October 2019

С апреля 2019 года Группа компаний Iskratel, представленная в России АО "ИскраУралТЕЛ", перешла на новую организационную структуру, которая отразила новый этап в диверсификации бизнеса этого известного поставщика телекоммуникационных и ИТ-решений с присутствием в примерно 50 странах мира.
La democracia continua, un contrasentido que hace sentido
Authors: Rousseau Dominique
Published: October 2019

En la teoría de la democracia, para diferenciar la forma política de producción de la voluntad general sin control de constitucionalidad de la forma política con control de constitucionalidad, se propuse que la primera se llame «democracia electoral» porque su principio activo es la elección, y la segunda «democracia continua» porque el control del juez constitucional respecto de la producción de la ley es el principio activo entre dos momentos electorales. Así, dos principios activos diferentes y, por lo tanto, dos denominaciones diferentes. Evidentemente esta propuesta ha dado y da pie al debate sobre dos puntos principales: la posibilidad de hacer de la democracia un objeto de la constitución y la pertinencia de llamar «democracia» a una configuración política en la que un juez participa en la fabricación de la voluntad general.
Faktor Risiko Tuberkulosis Paru pada Masyarakat di Wilayah Kerja Puskesmas Bambu Apus Kota Tangerang Selatan
Authors: Alnur Rony Darmawansyah , Pangestika Rismawati
Published: October 2019

ABSTRACT

Pulmonary tuberculosis is a contagious disease that is still a problem in the world of health until now. Pulmonary tuberculosis attacks the lungs caused by Mycrobacterium tuberculosis. Indonesia is included in a country with a high burden of tuberculosis, ranking 4th as a contributor to tuberculosis after India, China and South Africa.This study aims to determine internal risk factors that can cause pulmonary tuberculosis in the Dhuafa population.

This type of research is analytical with a case control Study. The sample study was divided into case and control samples totaling 30 people with pulmonary tuberculosis and 30 people non-pulmonary tuberculosis. Univariate data were analyzed descriptively and bivariate data were analyzed by Chi-Square test with a 95% confidence level.

The results of this studied showed that the risk factors that was the caused of the incidence of pulmonary tuberculosis in the work area of ​​Bambu Apus Health Center were a household contact with patient pulmonary tuberculosis. (OR: 3.5; 95% CI: 1.112-11,017; p = 0.028) and habit of smoking family at home (OR: 4,333; 95% CI: 1,203-15,605; p = 0,020). The education level and occupancy density were variables that have no relationship with the incidence of pulmonary tuberculosis in the work area of ​​Bambu Apus Health Center.

Keywords: Pulmonary Tuberculosis, Risk Factors, Dhuafa
Assessment of Health Related Quality of Life in Patients with Epilepsy
Authors: Jauhari Reenoo , Sati Aarti , Aqeel Nuvera
Published: October 2019

Background: Estimation of Quality of life is a useful outcome measure to know about epilepsy care from patient’s perspective. Assessing QOL of epileptic patients is important so as to manage the epilepsy and to implement some interventional programs in order to improve the quality of life of these patients. The study aims to find out the impact of epilepsy on quality of life of epileptic patients

Material and method: This was a cross-sectional, questionnaire-based study, conducted from March to August 2019 for a period of 6 months, after approval from Institutional Ethics Committee. Data was analyzed using Statistical Package for Social Sciences (SPSS) version 25. The quality of life in epilepsy (QOLIE-31) was used for collecting data on health-related QOL.

Result: The study group consisted of 65 patients of whom 48 were males (73.84%) and 17 were females (26.15%). Their ages ranged from 19 to 60 years. (mean age: 35.65). Majority of the patients were in the age range of 30-41 (40%). 50.8% participants were from nuclear family and 49.2% were from joint family system. Most of the patients had lower class socioeconomic status (61.5%). As regard to the employment status, 38.4% of patients were full time employed, 13.8% were part time employed. 29.2% were unemployed and 9.23% were retired and 9.23% were students.  The medication analysis revealed that 30.6% of the participants were on monotherapy whereas 69.0% were on polytherapy. The mean total QOLIE-31 score was 39.12 (SD-5.00).

Conclusion: Epileptic patients had poor QOL with low total QOLIE-31 score, unemployment, use of combination therapy and people belonging to lower class were associated with lower quality of life in individuals with epilepsy.

Keywords: Health Related Quality of life, Epilepsy, Quality of Life in Epilepsy (QOLIE-31) questionnaire
Long-term maintenance therapy with Cyclosporine A in adults with generalized pustular psoriasis
Authors: El-Reshaid Kamel , Shaima Al-Bader
Published: October 2019

Generalized pustular psoriasis (GPP) is a rare and serious immune-mediated skin disorder that is characterized by a widespread eruption of sterile and subcorneal pustules.  In the present study we investigated the efficacy of Cyclosporine A (Cy A) in treatment of 9 adults with drug-refractory GPP viz. topical Corticosteroids, retinoids, methotrexate and narrow-band ultraviolet light exposure (UVB).  Initially; they were resuscitated as burn patients. Cy A was administered on day 1 at a dose of 100 mg twice daily either in the form of syrup or Neoral capsules.  In most patients, skin lesions had healed by 6 weeks and the dose of Cy A was reduced to minimum to prevent further recurrence.  Seven patients had required 50 mg twice daily and 2 were controlled with 50 mg am and 25 mg pm.  On follow up, there was no serious relapse, liver and kidney disease.  Minor complications included; hirsutism and dark skin (n: 5) and gingival hyperplasia (n: 2). Trial to replace Cy A with Tacrolimus (Prograf) failed to maintain remission.  In conclusion; Cy A is a safe and effective treatment for GPP.

Keywords: Cyclosporin A, treatment, psoriasis, pustular.
Antioxidant and Antidiabetic Activities of Fresh Aqueous Pink Petals of Indian Lotus-Nelumbo nucifera Gaertn.
Authors: Saraswathi K , Sivaraj C , Fransila B , Arumugam P
Published: October 2019

The genus Nelumbo is endowed with a number of medicinally important activities antidiabetic, antipyretic, anti-inflammatory, anti-cancerous, antimicrobial, antiviral and anti-obesity properties. Furthermore, Nelumbo nucifera flowers are served as healthy beverages to treat hypertension, cancer, diarrhea, fever, weakness, infection and body heat imbalance. It has been widely used in folk medicine for the treatment of various inflammatory and infectious diseases. Current research studies were carried out for evaluating the antioxidant, antidiabetic and antibacterial activities of fresh aqueous pink petals of Nelumbo nucifera. Antioxidant activities such as DPPH˙ radical, Superoxide (O2.-) radical, ABTS●+ radical cation, phosphomolybdenum reduction and Fe3+ reduction were carried out for fresh aqueous pink petals of Nelumbo nucifera. The maximum DPPH˙ radical scavenging activity was 88.33±0.47% at 300 µg/mL concentration and the IC50 value was 131.68 µg/mL concentration. The maximum superoxide (O2.-) radical scavenging activity was 86.76±0.31% at 120 µg/mL concentration and the IC50 value was 21.31 µg/mL concentration. The maximum ABTS●+ radical cation scavenging activity was 69.55±0.26% at 30 µg/mL concentration and the IC50 value was 10.82 µg/mL concentration respectively. The maximum Mo6+ reduction was 84.54±0.21% at 45 µg/mL concentration and the RC50 value of Mo6+ reduction was 25.79 µg/mL concentration. The maximum Fe3+ reduction was 56.00±0.38% at 300 µg/mL concentration and the RC50 value of Fe3+ reduction was 177.30 µg/mL concentration respectively. The maximum alpha amylase enzyme inhibition was 66.37±0.10% at 300 µg/mL concentration and the IC50 value was 63.84 µg/mL concentration respectively. The antibacterial activity of fresh aqueous pink petals of Nelumbo nucifera showed maximum zone of inhibition of 14 mm for B. subtilis and minimum zone of inhibition of 10 mm for E. coli at 375 µg/mL concentration. 

Keywords: Antioxidant, Superoxide (O2.-) radical, ABTS●+ radical cation, Fe3+ reduction and alpha-amylase.
Phytochemical Analysis and Antioxidant Potential of Rhizome Extracts of Curcuma amada Roxb and Curcuma caesia Roxb
Authors: Yadav Mamta , Saravanan K. Kalyan
Published: October 2019

Plants have served human beings as a natural source for treatments and therapies from ancient times, amongst them medicinal herbs have gain attention because of its wide use and less side effects. In the recent years plant research has increased throughout the world and a huge amount of evidences have been collected to show immense potential of medicinal plants used in various traditional systems. Curcuma amada Roxb (C. amada, Zingiberaceae) is a perennial, rhizomatous, aromatic herb commonly known as Amada or Amahaldi or mango ginger due to the raw mango-like aroma of the rhizome. It is used medicinally as a coolant, astringent and to promote digestion. Curcuma caesia Roxb (C. caesia, Zingiberacea) is a perennial herb with bluish black rhizomes commonly known as black turmeric and are traditionally used in treatment of various ailments and metabolic disorders like leukoderma, asthma, tumours, piles, bronchitis, etc. in Indian system of medicine. The aim of the present study was to evaluate in vitro antioxidant activities and qualitative and quantitative phytochemical analysis of rhizome of C. amada and C. caesia collected from Bhopal region of Madhya Pradesh. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenolics and flavonoids were determined by the well-known test protocol available in the literature. The in vitro antioxidant activity of methanolic extract of the rhizome was assessed against DPPH assay method using standard protocols. Phytochemical analysis revealed the presence of phenols, flavonoids, tannins, saponins, alkaloids. The total flavonoids content of methanolic rhizomes extract of C. caesia and C. amada was found to be 2.752 and 2.920 mg/100mg respectively. The activities of methanolic rhizomes extract against DPPH assay method were concentration dependent with IC 50 values of ascorbic acid and extracts 14.11 and 170.81, 63.69μg/ml respectively. The diverse array of phytochemicals present in the plant thus suggests its therapeutic potentials which may be explored in drug manufacturing industry as well as in traditional medicine.

Keywords: Curcuma amada, Curcuma caesia, Zingiberacea, Phytochemical analysis, Antioxidant
Educação integral em tempo integral: o bairro como território educativo
Authors: Rocha Daniel Rômulo de Carvalho , Souza Maria Celeste Reis Fernandes de
Published: October 2019

O artigo tem como cenário o debate da educação integral/tempo integral que convoca as escolas a uma maior abertura para a cidade e apresenta resultados de uma pesquisa que cartografa territórios educativos em um bairro da cidade de Governador Valadares. O aporte teórico se sustenta em autores que abordam a educação integral e nos estudos de Henri Lefebvre, Paul Claval e Michel de Certeau. Os dados foram coletados por meio de documentos e observação caminhante. Os resultados apontam um bairro com praças e ruas com pouca circulação de pessoas e de práticas cotidianas de moradores. As conclusões destacam a necessidade da garantia do direito à cidade e refletem sobre a importância de um maior diálogo entre a escola e o bairro, que pode se converter em território de aprendizagens cidadãs.
Implementing BIM and Finite Element Analysis in a Structural Integrity Investigation of Curtain Walls
Authors: Patil Gouree P. , Chen Don , Mayo Glenda , Smithwick Jake , Barclay Nicole
Published: October 2019

Evaluating the structural integrity of curtain walls during the life cycle of a building project can assist architects in developing better designs, help contractors establish better installation methods, and allow facility managers make informed maintenance decisions. This paper presents an effort to develop a process which combines three types of technologies: 3D laser scanning, Building Information Modeling (BIM), and Finite Element Analysis (FEA), to evaluate the structural integrity of a curtain wall. In a case study, a 3D laser scanner was used to scan the curtain wall, the resulting set of point clouds was used to create an actual as-built BIM model. This “as-is” BIM model is different than a construction as-built BIM model in that the former model captures existing deformations developed during construction, installation, and maintenance phases. Then further analysis was completed using simulation with FEA using the BIM model to potentially predict any future structural issues. Wind loads on the building façade and their effect on unintentional stresses built into the glass panel were studied. The final results inform of deformities in the curtain wall and show the amount of wind load the structure can support before there is a risk of structural damage. The contribution of this study is that the harmonious three-step technique quickens the entire process of identifying the risks to a building element. An additional use for these common software packages would be beneficial to all the stakeholders involved in the life cycle of the building, especially those concerned with the facilities management and the building life cycle.
Gambaran Pengetahuan, Sikap dan Tindakan Masyarakat pada Peningkatan Kasus Malaria di Kabupaten Purworejo Tahun 2015
Authors: Trapsilowati Wiwik , Pujiyanti Aryani , Wigati Wigati
Published: October 2019

There has been increased of malaria cases in Purworejo District, especially in Sendangsari Village, Bener District in 2015. The one influence factors of malaria transmission was behavior, it consist of knowledge, attitude and practice domains. The aims this study was described of the knowledge, attitudes and practices of the community and conduct interventions related to survey results. The research method were cross-sectional to collect data of the knowledge, attitudes and practices and one group pretest posttest design to measure the intervention. The number of samples obtained as many as 90 respondents. The results showed that there was a significant relationship between education and knowledge, as well as knowledge with attitude (p < 0.05). While variables relationship of knowledge with practice/action and attitude with practice/action showed an insignificant (p > 0,05). The result of the intervention by direct information showed that knowledge of the respondents between before and after intervention has increased significantly (p < 0,05). Based on these results, it was necessary to encourage local community leaders, both formal and non-formal, for cooperate with the community to protecting themselves and their environment so as not to be potential transmission of malaria
Coexistence of BRAFV600E mutation and EGFR overexpression is highly associated with adverse clinicopathological features of papillary thyroid carcinoma
Authors: Paunovic Ivan , Selemetjev Sonja , Isic-Dencic Tijana , Djoric Ilona , Jankovic-Miljus Jelena , Roncevic Jelena , Cvejic Dubravka
Published: October 2019

Papillary thyroid carcinoma (PTC) generally has a good prognosis, but in a subset of patients it progresses to aggressive forms. Analysis of molecular alterations in relation to clinical phenotype may help in risk stratification of patients by predicting tumor aggressiveness. We analyzed the expression profiles of epidermal growth factor receptor (EGFR) using immunohistochemistry and the presence of BRAF(V600E) mutation by mutant allele-specific PCR in PTC tissue samples (n=92) in relation to clinicopathological parameters. BRAFV600E was detected in 46.7% of patients and correlated with the presence of lymph node metastasis (LNM, p=0.035) and extrathyroid invasion (EI, p<0.0001). EGFR overexpression was detected in 52.2% of the patients and also correlated with LNM (p<0.0001) and EI (p=0.027). Among patients with a single alteration, the presence of BRAFV600E impacted EI, while EGFR overexpression alone had a greater impact on LNM. The strongest association with adverse features was found in PTC patients with coexisting BRAFV600E and EGFR overexpression (28.3%), among whom LNM and EI were evident in 73% and 69%, respectively (p<0.0001, for both). Thus, the coexistence of BRAFV600E mutation and EGFR overexpression identifies high-risk PTC patients, who should be considered for combined molecular therapy offering a better long-term therapeutic outcome.
Pengaruh Kompetensi, Time Budget Pressure, dan Kompleksitas Audit Terhadap Kualitas Audit dengan Pemahaman Sistem Informasi Sebagai Variabel Moderasi
Authors: Arisanti Lovilian Rayi , Susbiyani Arik , Martiana Nina
Published: October 2019

Tujuan dari penelitian ini adalah untuk menganalisis pengaruh persaingan, tekanan anggaran waktu, dan kompleksitas audit terhadap kualitas audit dengan menggunakan pemahaman sistem informasi sebagai variabel moderasi.Partisipan dalam penelitian ini adalah 50 auditor yang bekerja di Kantor Akuntan Publik di Malang. Teknik pengambilan sampel yang digunakan adalah dengan menggunakan teknik purposive sampling non probabilitas. Kuesioner disediakan sebagai pengumpulan data, dan analisis data yang digunakan adalah regresi linier berganda. Data sedang diproses dengan menggunakan perangkat lunak bernama Paket Statistik untuk Ilmu Sosial (SPSS) versi 23.Hasil penelitian menunjukkan bahwa persaingan memiliki dampak positif, tekanan anggaran waktu dan kompleksitas audit berdampak negatif terhadap kualitas audit. Pemahaman sistem informasi tidak memoderasi persaingan, tekanan waktu anggaran, dan kompleksitas audit dengan kualitas audit. Saran dari saya bagi auditor untuk menjaga kualitas audit dalam semua situasi, dan bagi peneliti selanjutnya adalah memiliki studi kasus di Kantor Akuntan Publik dengan menggunakan metode kualitatif dan wawancara.
The role of digital/online resources in the Jewish Diaspora communities
Authors: Winer Dov
Published: October 2019

Globalization, in its earlier stages, was expected to erode national and ethnic identities. In contrast, ethnicity and ethnic affiliations persisted, growing socially and politically. This paper examines the role of the globalizing new communications technologies on this process, focusing on Diasporas. The study of trans-state networks based on ethnic solidarity, connections and affinities in the framework of social and political science is quite recent. Following a clarification of the distinction between classical and modern Diasporas we analyse a particular case study, that of the Jewish Diaspora. This diaspora was an early adopter of computer-based communications and the Internet for a wide range of purposes. Early events are described including the diffusion of the Internet to Israel, the planning of a Global Jewish Information Network, Israel 2020 macro scenarios for Israel and the Jewish People and the decision on Jewish Peoplehood through communication technologies. A survey of historical systems (Responsa, BBS, and Usenet) follows by a description of the Jewish population and the wide variety of Jewish Web based activities today. These include the Institutional landscape; Jewish media — press, radio, video and blogs; the impact on Jewish religious observance; Jewish genealogy; Online dating; Social networks; Jewish education; Online learning; Jewish Studies and Digital Humanities; Jewish memory. Judaica Europeana supports the activities previously described by aggregating and facilitating the access and the re-use of Jewish digital culture. Europeana is the leading global digital library for cultural heritage as well as a lively eco-system for relevant stakeholders.
Risk factors for hypertension among Ghanaian: Evidence from Ghana demographic and health survey
Authors: Dzokoto Maxwell Kwame , Kpen Bruce , Adam Ibrahim , Baafi Anokye Akwasi
Published: October 2019

Background: Hypertension is considered an important challenge in public health due to its high risk of cardiovascular disease, kidney disease and death. Despite interventions aimed at reducing the prevalence of hypertension, it still remains the leading cause of stoke and other related diseases and it accounts for 12.8% of all deaths worldwide. The goal of this paper is to explore factors that influences hypertension among men in Ghana. Knowledge of these factors will help public health practitioners provide targeted interventions which will result in a significant reduction of hypertension among the population.Methods: Data source is a survey aimed at collecting data on the indicators of the millennium development goals. Hypertension was the main outcome. Socioeconomic status (primary exposure variable) as well as other potential determinants were assessed. Analytic techniques included multiple Poisson regression that assessed the effects of potential covariates on hypertension in a hierarchical manner. Crude and adjusted prevalent rate ratios are reported with their corresponding 95% confidence intervals at 5% level of significance.Results: The overall prevalence rate of hypertension among Ghanaian men is 8%. Age was found to be a significant predictor of hypertension. Wealth index is also a significant predictor of hypertension with men in levels 4 and 5 more likely to develop hypertension compared to those belonging to level one after adjusting for other covariates. Men with secondary education were 23% more likely to develop hypertension compared to those with higher education, however those with no formal education were 32% less likely to develop hypertension compared to those with higher education after adjusting for other covariates. After adjusting for other covariates, professionals/technical/managerial workers were 35% more likely to be hypertensive compared to those engaged in farming. Men who visited some health facility within the last six months preceding the study were more likely to be hypertensive against those who did not visit any health facility within the same period. Hypertension is more prevalent among parents who lost two or more children compared to parents who were not bereaved. After adjusting for confounders, men with two or more lifetime partners were 13% more likely to be hypertensive as against those with only one lifetime partners.Conclusion: The rate of hypertension in Ghana is high. Factors such as age, wealth index, occupation, bereavement and number of lifetime partners are significant predictors of hypertension after adjusting for potential covariates.
Energy Efficient Healthcare Monitoring System using 5G Task Offloading
Authors: Sigwele Tshiamo , Sigwele Tshiamo , Naveed Arjmand , Hu Yim-Fun , Ali Muhammad , Susanto Misfa
Published: October 2019

Healthcare expenses can be significantly reduced, and lives saved by enabling the continuous monitoring of patient health remotely using Wireless Body Sensor Networks (WBSN). However, an energy efficient mobile gateway (e.g. 5G smartphone) is required which moves with the patient in real time to process the data from the bio sensors without depleting the battery. This paper proposes a 5G based healthcare cardiovascular disease REmote Monitoring system called 5GREM using Electrocardiogram (ECG) bio sensor as a BSN device. The aim is to monitor and analyse the patient’s heart rhythms and send emergency alerts during irregularities to the nearest caregivers, ambulance or physician to minimise heart attacks and heart failures while saving energy. Since ECG signal execution is computer intensive, requests from the ECG sensor are either executed locally on the gateway, offloaded to nearby mobile devices or to the 5G edge while considering the battery level, CPU level, transmission power, delays and task fail rate
Internal carotid and vertebral artery dissection: morphology, pathophysiology and provoking factors
Authors: Kalashnikova LA , Gulevskaya TS , Sakharova AV , Chaykovskaya RP , Gubanova MV , Danilova MS , Shabalina AA , Dobrynina LA
Published: October 2019

The causes of internal carotid artery (ICA) and vertebral artery (VA) dissection, as well as its provoking factors, remain understudied. The aim of this paper was to explore morphological changes in the ICA/VA walls, factors provoking dissection, clinical signs and biomarkers of connective tissue (CT) damage. A total of 271 patients were examined, of whom 54% were women. The mean age of the participants was 37.0 ± 10 years. Clinical signs and biomarkers of CT damage (matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1, hydroxyproline, sulphated glycosaminoglycans) were analyzed in 82 patients and 40 healthy volunteers. Histologic examination of dissected and seemingly intact arteries conducted in 5 cases revealed signs of arterial wall dysplasia similar to those characteristics of fibromuscular dysplasia: thinning and splitting of the internal elastic membrane, areas of fibrosis, irregular orientation of myocytes, and their necrosis in the tunica media. Clinical signs and biomarkers of CT dysplasia (CTD) were more pronounced in patients with arterial dissection than in the controls. The major provoking factors were head turns and physical activity (42%), minor head injury (10%), and acute respiratory infection in the month preceding arterial dissection (14%). We conclude that arterial wall dysplasia is a predisposing factor for ICA/VA dissection, both spontaneous and provoked. The analysis of CTD biomarkers and clinical signs suggests connective tissue pathology in patients with ICA/VA dissection.
CAR T-cell therapy of solid tumors: promising approaches to modulating antitumor activity of CAR T cells
Authors: Kiseleva Ya.Yu. , Shishkin A.M. , Ivanov A.V. , Kulinich T.M. , Bozhenko V.K.
Published: October 2019

Adoptive immunotherapy that makes use of genetically modified autologous T cells carrying a chimeric antigen receptor (CAR) with desired specificity is a promising approach to the treatment of advanced or relapsed solid tumors. However, there are a number of challenges facing the CAR T-cell therapy, including the ability of the tumor to silence the expression of target antigens in response to the selective pressure exerted by therapy and the dampening of the functional activity of CAR T cells by the immunosuppressive tumor microenvironment. This review discusses the existing gene-engineering approaches to the modification of CAR T-cell design for 1) creating universal “switchable” synthetic receptors capable of attacking a variety of target antigens; 2) enhancing the functional activity of CAR T cells in the immunosuppressive microenvironment of the tumor by silencing the expression of inhibiting receptors or by stimulating production of cytokines.
WHAT IS SO SCARY ABOUT LEARNING ENGLISH? INVESTIGATING LANGUAGE ANXIETY AMONG FILIPINO COLLEGE STUDENTS
Authors: Gatcho Al Ryanne Gabonada , HAJAN BONJOVI HASSAN
Published: October 2019

Learning English as a foreign/second language is never a straightforward process. Several constraints may come along the way that tend to hinder students’ learning. Studies have shown that the successes and failures of L2 learners in an English language classroom are dependent upon various psychological and social factors including anxiety. This study examined the English language learning anxiety of Filipino college students. The Foreign Language Classroom Anxiety survey adapted from Horwitz, Horwitz and Cope (1986) was administered to a group of 150 students randomly selected from 5 programs at a private university in the Philippines to identify students’ anxiety level in terms of fear of negative evaluation, communication apprehension, fear of test, and anxiety of English class and to determine which factor is most probable to cause anxiety among them.. The results indicated that the students expressed different levels of anxiety among the four factors as majority provided answers ranging from neutral to strongly agree. However, it was discovered that fear of negative evaluation and communication apprehension were the most probable to cause anxiety among them. The study offers practical implications as to how L2 teachers can help students overcome their English anxiety and thus be successful in the learning of the target language.
ANALISIS PERILAKU KOMPLAIN KONSUMEN ONLINE SHOPPING
Authors: Aisyiyah Nasyiatul , Hartoyo , , Krisnatuti Diah
Published: October 2019

Online business has a strong role to meet consumer need but this business still has limitation so cause increasing of complaint behavior. This study aims to analyze the influence of the quality of online product and service on consumer complaint behavior and its relation with consumer’s personality. The study used cross sectional desaign with online survey. Respondents were 161 college student of 17-22 years old and chosen by purposive sampling based on the criteria of having experienced dissatisfaction in online shopping in the past year. Data were analyzed descriptively and SEM (Structural Equation Modelling) with Smart-PLS software. The result show that consumer dissatisfaction is caused by product defect, delivery time, and product deliver failed. Fashion and cosmetic categories have the highest level of dissatisfaction. Online shopping consumers have various ways to respond to dissatisfaction including passive (34.0%), (voicer 40.0%), iratest (25.0%), and activists (1.0%). Consumer complaint behavior is positively and significantly influenced by perceived quality (product and service) and personality. It means that the higher level of defect in product and service perceived by customers, the higher level of complains that consumers will make. Furthermore, consumer personality characteristics of extraversion and openness to experience are more likely to complaint if there is an error in product or service.
Paternal Smoking May be Associated with Increased Risk of Miscarriage
Authors: Hassan Syed Zawahir , Saberian Chantal , Karrar Khan Sadaf , Salam Osama
Published: October 2019

This letter to editor discuss about Paternal Smoking and Increased Risk of Miscarriage
Linkage Between Serum Vitamin D and Precancerous Colon Polyps: Letter to Editor
Authors: Fatima Syeda Faryal , Hassan Syed Zawahir , Khan Sadaf Karrar , Bhali Atiqa
Published: October 2019

Colon cancer is the third most common type of cancer in the USA and accounts yearly for 11% of all cancer deaths (Center for Disease Control and American Cancer Society). Thus, identifying strategies that reduce its incidence is critically important. Calcitriol, the most active form of vitamin D, is a pleotropic hormone with a wide range of biological activities. Due to its ability to regulate calcium and phosphate metabolism, 1,25D3 plays a major role in bone health. In addition, 1,25D3 binds to the vitamin D receptor and thereby regulates the expression of a number of genes which control growth, differentiation and survival of cancer cells. Although a well-recognized physiological role of vitamin D is the regulation of calcium and phosphate metabolism, recent studies suggest a much broader range of biological functions of vitamin D, including potential anti-neoplastic effects. Garland et al. discovered in 1980 that colon cancer mortality rates in the U.S. were highest in places where populations were exposed to the least amount of sunlight, and proposed that vitamin D might be a protective factor against colon cancer. Since then, extensive studies have reported anti-neoplastic actions of vitamin D, particularly in colorectal cancer.
Anatomical characterization, histochemistry and crystal analysis of the leaf blade of Mangifera indica L.
Authors: Sá Rafaela Damasceno , Cavalcanti Girllene da Silva , Santos Deysielle Maria dos , Silva Adolfo Santos da , Padilha Rafael José Ribeiro , Alves Luiz Carlos , Randau Karina Perrelli
Published: October 2019

Mangifera indica L., popularly known as mangueira, is an important fruitful widely used in Brazilian traditional medicine for the treatment of diabetes, anemia, diarrhea, hemorrhoids, indigestion, asthma, bronchitis, flu, hypertension, rheumatism, disorders of the liver and for tumors. In order to expand the pharmacobotanical information about the species, this study aimed to perform the anatomical characterization, histochemistry and crystal analysis of the leaf blade of M. indica. For the anatomical characterization were used optical microscopy, polarization microscopy and scanning electron microscopy. Histochemical tests were performed to evidence the presence of metabolites and microchemical analyzes by dispersive energy spectroscopy were done to determine the elemental chemical composition of the crystals. The microscopic analysis allowed the identification of characters useful in the identification of the species, such as the presence of glandular trichomes in the leaf blade. Through histochemistry was evidenced the presence of phenolic compounds, lipophilic substances, lignin and starch in the leaf blade. The chemical nature of the crystals was determined to be calcium oxalate. The results contribute to the pharmacobotanical standardization of M. indica.
Logic of an Effectuating Hyperlocal
Authors: Tenor Carina
Published: October 2019

This article examines motivations, rewards and strategies in hyperlocal news entrepreneurship. The material is an interview study with eight entrepreneurs who independently own and manage hyperlocal news sites in Sweden. The conclusion is that the means of the hyperlocal entrepreneur both motivate and create an obstacle for growth. The findings of struggling business models, self-exploitation and civic motivations correspond with previous research in different countries, but alternative perspectives are suggested drawing from theories of entrepreneurial passion and processes. Civic motivations can be viewed as part of entrepreneurial passion, and the precarious nature as a low-risk effectuation process. The effectuator explores possible outcomes of given means and builds the business by controlling the affordable loss rather than calculating the possible return. Along with the obvious difficulty in finding a profitable business model when operating in a very small market, this implies a new perspective on failure and success in hyperlocal entrepreneurship, but also underlines that any measures of support for the sector need to be easily accessible for the individual entrepreneur.