bluuebunny/crossref_metadata_2025 huggingface dataset:
Review of Spider Silk Applications in Biomedical and Tissue Engineering
Authors: Branković Marija , Zivic Fatima , Grujovic Nenad , Stojadinovic Ivan , Milenkovic Strahinja , Kotorcevic Nikola
Published: March 2024

This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems. Silk is one of the toughest natural materials, with high strain at failure and mechanical strength. Novel biomaterials with silk fibroin can mimic the tissue structure and promote regeneration and new tissue growth. Silk proteins are important in designing tissue-on-chip or organ-on-chip technologies and micro devices for the precise engineering of artificial tissues and organs, disease modeling, and the further selection of adequate medical treatments. Recent research indicates that silk (films, hydrogels, capsules, or liposomes coated with silk proteins) has the potential to provide controlled drug release at the target destination. However, even with clear advantages, there are still challenges that need further research, including clinical trials.
A Three-Dimensional Seismic Damage Assessment Method for RC Structures Based on Multi-Mode Damage Model
Authors: Guo Xiang , Liu Shuo , Wang Xiang , Yang Fujian , Zhang Yantai
Published: March 2024

To rationally evaluate the seismic damage of RC structures comprehensively and multi-dimensionally, a damage index calculation method is proposed. This is a macroscopic global seismic damage model that considers torsional damage, damage in two perpendicular horizontal directions, as well as the overall damage, based on the modal characteristics of the three-dimensional structure and the multi-mode damage model. Formulas are derived, and the steps for damage evaluation are summarized. To better illustrate the results of the proposed method, an example of an asymmetric 6-story frame-shear wall structure is built using the OpenSees program. Thirteen ground motions are selected for incremental dynamic analysis. The structure’s damage indexes are evaluated according to the proposed method and compared with the corresponding structural responses, He et al.’s index, and the Final Softening index. The results demonstrate that the proposed method can fully reflect the macroscopic damage state of the structure from different perspectives. Additionally, the results show that, despite the ground motion only acting in the y-direction, the structure exhibits responses and damage in both the x-direction and the torsional direction. The overall damage to the structure is primarily controlled by the torsional damage, attributed to the asymmetric arrangement of shear walls. The torsional effect is the key factor leading to the failure of asymmetric structures during earthquakes. Therefore, ensuring the torsional strength of the structure is crucial during the structural design process.
Development of a BIM Platform for the Design of Single-Story Steel Structure Factories
Authors: Wang Dejiang , Lu Haojie
Published: March 2024

Traditional design methods for single-story steel structure factories are characterized by low levels of digitalization and high error rates. To deal with these problems, a building information modeling (BIM) platform for the design of single-story steel structure factories was developed in this paper, which aimed to improve the design process for such structures. Firstly, the components of the factory were categorized, and the Revit API was employed to automate the generation of the BIM model. Load applications and combinations were then established using the Revit API, which relied on a set of predefined parameters. Secondly, this paper proposed the creation of a dedicated database for data exchange between BIM software and finite element analysis software. Additionally, the SAP2000 Open Application Programming Interface (OAPI) was employed for the automated construction and analysis of the SAP2000 structural model. Finally, the innovative use of Dynamo–Revit API hybrid programming allowed for the visualization of internal forces directly within the Revit environment, significantly diminishing the dependency on standalone FEA software. The application results obtained on a project demonstrated that the developed platform markedly improves the efficiency of design single-story steel structure factories and ensures the accuracy of the structural analysis. This confirms that the developed platform can transform the traditional design process by integrating advanced digital tools, thereby providing a novel approach to the design of single-story steel structure factories.
Why Should We Pay Attention to Working Capital Management? A Case of Ghana
Authors: Baafi Joseph Antwi , Sarkodie Eric Effah , Duodu John Kwame , Kumah Seyram Pearl
Published: March 2024

The paper examines the nexus between working capital management (WCM) and financial performance of listed non-financial firms in Ghana. An unbalanced panel data for the period 2008 to 2021 was used for the study. It is observed that the residual terms of the models were cross-sectionally independent and all the series were first-differenced stationary and cointegrated in the long term The elasticities of the predictors were explored via the Fully Modified Ordinary Least Squares (FMOLS) and the Dynamic Ordinary Least Squares (DOLS) techniques. The findings of the study indicate that WCM proxied by accounts receivable period (ACP), accounts payment period (APP), and inventory turnover period (ITP) have significant positive effect on firms’ financial performance measured by return on assets (ROA), return on equity (ROE), and return on capital employed (ROCE). This suggests that the working capital management practices of non-financial firms in Ghana improve their financial performance. Also, firm size and asset growth improve firm financial performance. On the causalities between the variables, bidirectional causalities between ACP, APP, ITP, size, and thecompanies’ ROA, ROE, and ROCE are disclosed. Finally, causality from growth to the ROA, ROE, and ROCE of the firms are unraveled. It is recommended that policy makers of non-financial firms in Ghana should not overlook WCM practices in their financial decisions, since ignoring them could seriously compromise the firms’ short- and long-term sustainability.
CuSnBi Catalyst Grown on Copper Foam by Co-Electrodeposition for Efficient Electrochemical Reduction of CO2 to Formate
Authors: Xie Hangxin , Lv Li , Sun Yuan , Wang Chunlai , Xu Jialin , Tang Min
Published: March 2024

Effective electrochemical reduction of carbon dioxide to formate under mild conditions helps mitigate the energy crisis but requires the use of high-performance catalysts. The addition of a third metal to the binary metal catalyst may further promote the electrochemical reduction of carbon dioxide to formate. Herein, we provided a co-electrodeposition method to grow CuSnBi catalysts on pretreated copper foam and discussed the effects of both pH value and molar ratio of metal ions (Cu2+, Sn2+, and Bi3+) in the electrodeposition solution on the electrocatalytic performance of CO2 to HCOO−. When the pH value of the electrodeposition solution was 8.5 and the molar ratio of Cu2+, Sn2+, and Bi3+ was 1:1:1, the electrode showed the highest FEHCOO− of 91.79% and the formate partial current density of 36.6 mA·cm−2 at −1.12 VRHE. Furthermore, the electrode kept stable for 20 h at −1.12 VRHE, and FEHCOO− was always beyond 85% during the electrolysis process, which is excellent compared to the previously reported ternary metal catalytic electrodes. This work highlights the vital impact of changes (pH value and molar ratio of metal ions) in electrodeposition liquid on catalytic electrodes and their catalytic performance, and refreshing the electrolyte is essential to maintain the activity and selectivity during the electrochemical reduction of CO2 to HCOO−.
Piezo1 and Its Function in Different Blood Cell Lineages
Authors: Karkempetzaki Anastasia Iris , Ravid Katya
Published: March 2024

Mechanosensation is a fundamental function through which cells sense mechanical stimuli by initiating intracellular ion currents. Ion channels play a pivotal role in this process by orchestrating a cascade of events leading to the activation of downstream signaling pathways in response to particular stimuli. Piezo1 is a cation channel that reacts with Ca2+ influx in response to pressure sensation evoked by tension on the cell lipid membrane, originating from cell–cell, cell–matrix, or hydrostatic pressure forces, such as laminar flow and shear stress. The application of such forces takes place in normal physiological processes of the cell, but also in the context of different diseases, where microenvironment stiffness or excessive/irregular hydrostatic pressure dysregulates the normal expression and/or activation of Piezo1. Since Piezo1 is expressed in several blood cell lineages and mutations of the channel have been associated with blood cell disorders, studies have focused on its role in the development and function of blood cells. Here, we review the function of Piezo1 in different blood cell lineages and related diseases, with a focus on megakaryocytes and platelets.
CD74 Promotes Cyst Growth and Renal Fibrosis in Autosomal Dominant Polycystic Kidney Disease
Authors: Zhou Julie Xia , Cheng Alice Shasha , Chen Li , Li Linda Xiaoyan , Agborbesong Ewud , Torres Vicente E. , Harris Peter C. , Li Xiaogang
Published: March 2024

The progression of autosomal dominant polycystic kidney disease (ADPKD), an inherited kidney disease, is associated with renal interstitial inflammation and fibrosis. CD74 has been known not only as a receptor of macrophage migration inhibitory factor (MIF) it can also have MIF independent functions. In this study, we report unknown roles and function of CD74 in ADPKD. We show that knockout of CD74 delays cyst growth in Pkd1 mutant kidneys. Knockout and knockdown of CD74 (1) normalize PKD associated signaling pathways, including ERK, mTOR and Rb to decrease Pkd1 mutant renal epithelial cell proliferation, (2) decrease the activation of NF-κB and the expression of MCP-1 and TNF-alpha (TNF-α) which decreases the recruitment of macrophages in Pkd1 mutant kidneys, and (3) decrease renal fibrosis in Pkd1 mutant kidneys. We show for the first time that CD74 functions as a transcriptional factor to regulate the expression of fibrotic markers, including collagen I (Col I), fibronectin, and α-smooth muscle actin (α-SMA), through binding on their promoters. Interestingly, CD74 also regulates the transcription of MIF to form a positive feedback loop in that MIF binds with its receptor CD74 to regulate the activity of intracellular signaling pathways and CD74 increases the expression of MIF in ADPKD kidneys during cyst progression. We further show that knockout of MIF and targeting MIF with its inhibitor ISO-1 not only delay cyst growth but also ameliorate renal fibrosis through blocking the activation of renal fibroblasts and CD74 mediated the activation of TGF-β-Smad3 signaling, supporting the idea that CD74 is a key and novel upstream regulator of cyst growth and interstitial fibrosis. Thus, targeting MIF-CD74 axis is a novel therapeutic strategy for ADPKD treatment.
HDAC6 Enhances Endoglin Expression through Deacetylation of Transcription Factor SP1, Potentiating BMP9-Induced Angiogenesis
Authors: Sun Chen , Xie Kuifang , Yang Lejie , Cai Shengyang , Wang Mingjie , Zhu Yizhun , Tao Beibei , Zhu Yichun
Published: March 2024

Histone deacetylase 6 (HDAC6) plays a crucial role in the acetylation of non-histone proteins and is notably implicated in angiogenesis, though its underlying mechanisms were previously not fully understood. This study conducted transcriptomic and proteomic analyses on vascular endothelial cells with HDAC6 knockdown, identifying endoglin (ENG) as a key downstream protein regulated by HDAC6. This protein is vital for maintaining vascular integrity and plays a complex role in angiogenesis, particularly in its interaction with bone morphogenetic protein 9 (BMP9). In experiments using human umbilical vein endothelial cells (HUVECs), the pro-angiogenic effects of BMP9 were observed, which diminished following the knockdown of HDAC6 and ENG. Western blot analysis revealed that BMP9 treatment increased SMAD1/5/9 phosphorylation, a process hindered by HDAC6 knockdown, correlating with reduced ENG expression. Mechanistically, our study indicates that HDAC6 modulates ENG transcription by influencing promoter activity, leading to increased acetylation of transcription factor SP1 and consequently altering its transcriptional activity. Additionally, the study delves into the structural role of HDAC6, particularly its CD2 domain, in regulating SP1 acetylation and subsequently ENG expression. In conclusion, the present study underscores the critical function of HDAC6 in modulating SP1 acetylation and ENG expression, thereby significantly affecting BMP9-mediated angiogenesis. This finding highlights the potential of HDAC6 as a therapeutic target in angiogenesis-related processes.
Flourishing and Functional Difficulties among Autistic Youth: A Confirmatory Factor Analysis
Authors: Little Lauren M. , Schwefel Laura-Lee
Published: March 2024

The International Classification of Functioning, Disability, and Health for Children and Youth outlines body structures and functions and activities and participation to fully describe elements that support or detract from participation. While flourishing has gained attention in recent literature, research also points to the role of functional difficulties among autistic youth in influencing participation. Clearly, function is a multi-dimensional and complex construct and likely consists of both indicators of flourishing and functional difficulties. We used data from the National Survey of Children’s Health (NSCH) from 2016 to 2020 to identify aspects of flourishing functional difficulties to achieve the following aims: (1) Investigate the factor structure of flourishing and functional difficulties among autistic youth ages 10–17 years; and (2) examine the extent to which child variables (i.e., sex, age, race, ethnicity, autism severity, poverty) are associated with flourishing and functional difficulties. Autistic children (n = 2960) between the ages of 10 and 17 years were included. We used confirmatory factor analysis followed by a multivariate general linear model (GLM) to examine the association between child variables and factors. Results indicated a six-factor structure (medical conditions, instrumental activities of daily living, activities of daily living, social competence, behavioral control, and school motivation) with good model fit (root mean square error of approximation = 0.08 [p = 0.926], comparative fit index = 0.94, Tucker–Lewis index = 0.91). Multivariate GLM showed that child factors were differentially and significantly associated with factors of functional difficulties and flourishing. Current findings suggest that 16 items measured by the NSCH result in a six-factor structure of flourishing and functional difficulties among autistic youth. A comprehensive approach to capture function among autistic youth must assess aspects of flourishing and difficulties.
Did Inequalities in Mothers’ and Children’s Health and Well-Being in Japan Increase through the Pandemic? Evidence from Nationwide Surveys and Routinely Collected Data
Authors: Takeuchi Hajime , Satoh Yoichi , Raman Shanti , Spencer Nick
Published: March 2024

Marginalised families faced significant challenges during the COVID-19 pandemic. This study explores inequalities in Japanese mothers’ and children’s health and well-being and family economic stability before and during the pandemic. Data sources were as follows: nationwide surveys in 2019 and 2021 of families with children using medical institutions across Japan; infant mortality and adolescent suicide rates between 2018 and 2021 from publicly available sources. Outcomes by poor and non-poor families were compared for 2019 and 2021 using simple descriptive statistics. Poor mothers’ part-time working increased from 41% to 61% and regular employment was reduced by two thirds. The well-being of poor mothers worsened from 39% to 55%. Employment opportunities and well-being did not change for non-poor mothers. School subsidies among poor families increased from 23% to 55%. The infant mortality rate (IMR) among unemployed families increased significantly from 12.9/1000 to 18.2/1000 between 2018 and 2021 compared with a decreasing overall IMR from 1.9/1000 to 1.7/1000. Suicide rates in 10–19-year-olds increased over the same period although no socio-economic indicators were available. Inequalities in mothers’ and children’s health and well-being indicators and family economics increased between 2019 to 2021 in Japan. This study cannot attribute causes but suggests a possible role of the pandemic.
Caregivers’ Experience with Lip Taping as a Presurgical Orthopedic Treatment for Cleft Lip and Palate Defects
Authors: Thair Athar , Abid Mushriq , Dziedzic Arkadiusz
Published: March 2024

Background: This study aimed to assess caregivers’ experiences and perceptions of applying lip taping as presurgical orthopedic therapy (PSO) for infants with a cleft lip and palate. Methods: A retrospective survey was conducted, inviting parents to respond to a series of structured questions between September 2022 and June 2023. The questionnaire focused on evaluating parents’ experience with lip taping, a crucial component of PSO. Descriptive statistics and the Chi-square test were employed to analyze relationships between categorical variables. Results: Of the 157 participants, overall, 122 completed the survey, forming the dataset for analysis. A majority (90.0%) reported sufficient experience in using lip taping and no major difficulties with lip taping application. Caregivers with higher education levels exhibited a significantly positive correlation (p = 0.015). Additionally, 93.4% confirmed the efficacy of lip taping for premaxillary segment retraction, with this outcome being correlated with caregivers’ knowledge and education (p = 0.008). Interestingly, caregivers’ age also demonstrated a substantial association (p = 0.020). Conclusions: While a vast majority expressed positive experiences with lip taping as a presurgical treatment, continuous, tailored education on cleft lip and palate is imperative. This education should be directed towards caregivers and individuals offering direct support to parents of children with CLP, ensuring optimal care and preparation for surgical treatment.
Alterations of Nutritional Status in Children and Adolescents with Acute Lymphoblastic Leukemia
Authors: Kranjčec Izabela , Pranjić Ines , Roganović Jelena , Pavlović Maja , Rajačić Nada , Sila Sara
Published: March 2024

Malnutrition is often observed in pediatric cancer patients and has been recognized as a risk factor for relapse and survival. Maintaining an appropriate nutritional status during anticancer treatment has, therefore, been more and more frequently perceived as an additional requirement for optimal therapy outcomes. The aim of our study was to establish alterations of nutritional status in 26 children and adolescents treated for acute lymphoblastic leukemia (ALL) at the Children’s Hospital in Zagreb, Croatia, between 2016 and 2021, by using anthropometric measures and serum albumin levels. The majority of patients (53.8% female, median 4 years, 52.2% intermediate-risk leukemia group) had normal weight at the beginning of chemotherapy. The percentage of overweight/obese patients increased from 4.2% at diagnosis to 37.5% at the end of intensive therapy. Apart from a significant increase in body weight (BW) and body mass index (BMI) for age, a notable decline in body height/body length (BH/BL) for age in the observed period was recorded, especially in high-risk leukemia patients. The alterations in serum albumin values were not significant, nor was their correlation with BMI. Dietary consultation was offered to all patients, while children with a decline in BMI and BH/BL received additional nutritional support.
The Beneficial Role of Lactobacillus paracasei subsp. paracasei NTU 101 in the Prevention of Atopic Dermatitis
Authors: Liu Chin-Feng , Shih Tsung-Wei , Lee Chun-Lin , Pan Tzu-Ming
Published: March 2024

Atopic dermatitis (AD) is a recurrent allergic disease characterized by symptoms such as itching, redness, swelling, dryness, scaling skin, inflammation, and tissue damage. The underlying pathogenesis of AD remains unclear. Steroid drugs are commonly used in the clinical treatment of AD; however, their long-term use may lead to associated complications. Numerous studies have indicated that probiotics could modulate the immune system, enhance immune function, or suppress excessive immune responses. In this study, Lactobacillus paracasei subsp. paracasei NTU 101 (NTU 101) was orally administered for a duration of 4 weeks, followed by the induction of AD using ovalbumin (OVA) in a mouse model. The skin condition of the stimulated site was observed during the induction period. Subsequently, the serum immunoglobulin E (IgE) content, splenocyte T cell typing, and skin histological interpretation were examined to evaluate the efficacy of NTU 101 in alleviating AD symptoms in allergen-exposed animals. The findings indicated that administering NTU 101 beforehand effectively alleviated skin symptoms in animals with AD. It reduced the infiltration of inflammatory cells in skin tissue sections, and compared to the OVA group, there was a significant reduction in the thickening of the epidermal cell layer (decreased from 89.0 ± 20.2 µM to 48.6 ± 16.0 µM) and dermis layer (decreased from 310.3 ± 69.0 µM to 209.7 ± 55.5 µM). Moreover, the proportion of regulatory T (Treg) cells and T helper 2 (Th2) cells in splenocytes significantly increased, while the proportions of T helper 1 (Th1) and T helper 17 (Th17) cells did not differ. It is speculated that the potential mechanism by which NTU 101 prevents AD involves increasing the expression of Forkhead box protein P3 (FOXP3) and promoting Treg cell maturation, thereby alleviating allergic reaction symptoms associated with AD.
A Bee Trp-Arg Dense Peptide with Antiproliferation Efficacy against the Prostate Cancer Cell Line DU145
Authors: Kim Ye-eun , Kim Ki-Young
Published: March 2024

Prostate cancer accounts for 14% of male cancer-related fatalities in the UK. Given the challenges associated with hormone-based therapies in the context of androgen-independent prostate cancer, there is an imperative need for research into anticancer drugs. N0821, a peptide belonging to the Trp-Arg dense region and derived from the homologous region of various bee species, shows substantial potential for an anticancer effect. Both MTT assays and 3D spheroid assays were conducted to substantiate its antiproliferation potential and strongly indicated the antiproliferation effect of N0820 (WWWWRWWRKI) and N0821 (YWWWWRWWRKI). Notably, the mechanism underlying this effect is related to the downregulation of CCNA2 and the upregulation of CCNE1. Cell cycle arrest results from the reduction of CCNA2 in the S/G2 phase, leading to the accumulation of CCNE1. Our peptides were predicted to make an α-helix structure. This can act as an ion channel in the cell membrane. Therefore, we analyzed genes implicated in the influx of calcium ions into the mitochondria. Trp-Arg dense-region peptides are known for their antibacterial properties in targeting cell membranes, making the development of resistance less likely. Hence, further research in this area is essential and promising.
Unveiling the Ovarian Cell Characteristics and Molecular Mechanism of Prolificacy in Goats via Single-Nucleus Transcriptomics Data Analysis
Authors: Zhang Sanbao , Wei Yirong , Gao Xiaotong , Song Ying , Huang Yanna , Jiang Qinyang
Published: March 2024

Increases in litter size, which are influenced by ovulation, are responsible for between 74% and 96% of the economic value of genetic progress, which influences selection. For the selection and breeding of highly prolific goats, genetic mechanisms underlying variations in litter size should be elucidated. Here, we used single-nucleus RNA sequencing to analyze 44,605 single nuclei from the ovaries of polytocous and monotocous goats during the follicular phase. Utilizing known reference marker genes, we identified 10 ovarian cell types characterized by distinct gene expression profiles, transcription factor networks, and reciprocal interaction signatures. An in-depth analysis of the granulosa cells revealed three subtypes exhibiting distinct gene expression patterns and dynamic regulatory mechanisms. Further investigation of cell-type-specific prolificacy-associated transcriptional changes elucidated that “downregulation of apoptosis”, “increased anabolism”, and “upstream responsiveness to hormonal stimulation” are associated with prolificacy. This study provides a comprehensive understanding of the cell-type-specific mechanisms and regulatory networks in the goat ovary, providing insights into the molecular mechanisms underlying goat prolificacy. These findings establish a vital foundation for furthering understanding of the molecular mechanisms governing folliculogenesis and for improving the litter size in goats via molecular design breeding.
Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases
Authors: Morshed Md. Niaj , Akter Reshmi , Karim Md. Rezaul , Iqbal Safia , Kang Se Chan , Yang Deok Chun
Published: March 2024

Rare ginsenoside compound K (CK) is an intestinal microbial metabolite with a low natural abundance that is primarily produced by physicochemical processing, side chain modification, or metabolic transformation in the gut. Moreover, CK exhibits potent biological activity compared to primary ginsenosides, which has raised concerns in the field of ginseng research and development, as well as ginsenoside-related dietary supplements and natural products. Ginsenosides Rb1, Rb2, and Rc are generally used as a substrate to generate CK via several bioconversion processes. Current research shows that CK has a wide range of pharmacological actions, including boosting osteogenesis, lipid and glucose metabolism, lipid oxidation, insulin resistance, and anti-inflammatory and anti-apoptosis properties. Further research on the bioavailability and toxicology of CK can advance its medicinal application. The purpose of this review is to lay the groundwork for future clinical studies and the development of CK as a therapy for metabolic disorders. Furthermore, the toxicology and pharmacology of CK are investigated as well in this review. The findings indicate that CK primarily modulates signaling pathways associated with AMPK, SIRT1, PPARs, WNTs, and NF-kB. It also demonstrates a positive therapeutic effect of CK on non-alcoholic fatty liver disease (NAFLD), obesity, hyperlipidemia, diabetes, and its complications, as well as osteoporosis. Additionally, the analogues of CK showed more bioavailability, less toxicity, and more efficacy against disease states. Enhancing bioavailability and regulating hazardous variables are crucial for its use in clinical trials.
Effects of Laser Remelting on Frictional Properties of Supersonic Flame-Sprayed Coatings
Authors: Li Fengbo , Zhang Conghui , Li Yan , Pang Qingtao
Published: March 2024

In this study, Cr3C2-Al2O3-NiCr coatings were prepared on INCONEL 600 alloy surfaces using the supersonic flame spraying technique, followed by a laser remelting treatment. In this way, this study further explored what impacts laser remelting has on coating performance. To this end, optical microscopy (OM), scanning electron microscopy (SEM), and electron backscatter diffraction (EBSD) were employed to carry out microstructural characterization. Energy-dispersive X-ray spectroscopy (EDS) was applied to conduct an analysis of the coatings’ elemental distribution while X-ray diffraction (XRD) was used to determine the coating phases. To measure the microhardness of the coatings, a microhardness tester was applied. In addition, the study investigated the samples’ electrochemical corrosion resistance and friction-wear performance under different surface conditions. According to the results, laser remelting enhanced the coating density, improved metallurgical bonding with the substrate, and optimized the carbide distribution, thereby enhancing corrosion and wear resistance in both air and corrosive media. However, excessive laser power hinders Cr3C2 nucleation, leading to diminished coating hardness and wear resistance in Cr7C3 formation.
Study on Friction and Wear Characteristics of Axial Piston Pump Valve Plate Pairs Modified with Different Surface Energies
Authors: Liang Yingna , Wang Wei , Shen Miaomiao , Zhang Zhepeng , Xing Hao , Wang Cunyuan , Gao Dianrong
Published: March 2024

To explore the friction and wear performance of the valve pair with different wetting combinations under various working conditions in hydraulic oil lubrication, a low surface energy modification method was adopted in this paper to improve the surface wettability of the upper sample composed of SAF2507 and the lower sample composed of CFRPEEK, and to prepare valve plate pairs with different wetting combinations. The MMU-5G friction and wear testing machine was used to investigate its friction and wear characteristics under hydraulic oil lubrication. The results show that the surface free energy of SAF2507 and CFRPEEK decreased significantly after the treatment with a low surface energy solution, and the surface free energy of the upper and lower samples decreased by 41.9% and 42.2%, respectively. The oil contact angle of samples remained lipophilic, but the oil contact angle increased significantly. Under the working condition of low speed (800 r/min), the surface wettability of the valve plate pair has a great influence on its friction and wear characteristics. When operating at high speed (1200 r/min), the surface wettability of the valve plate pair has little influence on its friction and wear characteristics.
Study of Nd-NiMoO4 Nanocomposites Prepared by Sol–Gel Method and Their Capacitive Properties
Authors: An Lijuan , Ma Tenghao , Nie Yiran , Wang Jing
Published: March 2024

In this paper, NiMoO4 electrode materials doped with different concentrations of Nd rare earth metals were prepared by sol–gel method. Its morphology, structure, and spectral analysis were characterized by different scanning instruments, and the experimental results show that the NiMoO4 electrode material after adding 0.5% Nd doping showed excellent capacitance performance, with a specific capacity of 2182 F/g at a current density of 1 A/g. The capacitance retention was still 98.5% after 10,000 cycles at a current density of 5 A/g, which has a better electrochemical performance compared with the NiMoO4 material with superior electrochemical performance. In addition, an asymmetric capacitor device was prepared using 0.5% Nd-NiMoO4 material and CNTs as positive and negative electrodes, respectively, and the device showed a high energy density of 73.5 Wh/kg. In addition, the capacitor device still had a capacitance retention of 91.9% after 10,000 cycles. This paper provides an effective reference route for the preparation of rare-earth-doped bimetallic oxide electrode materials.
Rapid Experimental Protocol for PMSM via MBD: Modeling, Simulation, and Experiment
Authors: Hu Mingyuan , Ahn Hyeongki , Kang Hyein , Chung Yoonuh , You Kwanho
Published: March 2024

As control algorithms evolve, their enhanced performance is often accompanied by increased complexity, reaching a point where practical experimentation becomes unfeasible. This situation has led to many theoretical studies relying solely on simulations without experimental verification. To address this gap, this study introduces a rapid experimentation protocol (REP) for applying field-oriented control (FOC) strategies to permanent magnet synchronous motors (PMSMs) based on model-based design (MBD) and automated code generation. REP is designed to be user-friendly and straightforward, offering a less complex and more accessible alternative to DSP toolboxes. Its excellent hardware compatibility is conducive to code porting and development. With this protocol, users can quickly conduct FOC strategy experiments with reduced dependency on the complex automated code generation tools often associated with toolboxes. Centered around the PMSM model, this method utilizes only the fundamental modules of MATLAB2023b/Simulink, greatly simplifying the user experience. To demonstrate the feasibility and efficiency of the protocol, models for both sensor-based and sensorless control are developed. The practicality of REP, including sensor-based and sensorless experiments, is successfully validated on an arm-cortex-M4-based GD32 microcontroller.
Intelligent Traffic Engineering for 6G Heterogeneous Transport Networks
Authors: Hisyam Ng Hibatul Azizi , Mahmoodi Toktam
Published: March 2024

Novel architectures incorporating transport networks and artificial intelligence (AI) are currently being developed for beyond 5G and 6G technologies. Given that the interfacing mobile and transport network nodes deliver high transactional packet volume in downlink and uplink streams, 6G networks envision adopting diverse transport networks, including non-terrestrial types of transport networks such as the satellite network, High-Altitude Platform Systems (HAPS), and DOCSIS cable TV. Hence, there is a need to match the traffic to the transport network. This paper focuses on such a matching problem and defines a method that leverages machine learning and mixed-integer linear programming. Consequently, the proposed scheme in this paper is to develop a traffic steering capability based on types of transport networks, namely, optical, satellite, and DOCSIS cable. Novel findings demonstrate a more than 90% accuracy of steered traffic to respective types of transport networks for dedicated transport network resources.
Synthesis of BaZrS3 and BaS3 Thin Films: High and Low Temperature Approaches
Authors: Freund Tim , Jamshaid Sumbal , Monavvar Milad , Wellmann Peter
Published: March 2024

Current research efforts in the field of the semiconducting chalcogenide perovskites are directed towards the fabrication of thin films and subsequently determine their performance in the photovoltaic application. These efforts are motivated by the outstanding properties of this class of materials in terms of stability, high absorption coefficient near the band edge and no significant health concerns compared to their halide counterparts. The approach followed here is to use stacked precursor layers and is adopted from other chalcogenide photovoltaic materials like the kesterites and chalcopyrites. The successful synthesis of BaZrS3 from stacked layers of BaS and Zr and annealing at high temperatures (~1100 °C) with the addition of elemental sulfur is demonstrated. However, the film shows the presence of secondary phases and a flawed surface. As an alternative to this, BaS3 could be used as precursor due to its low melting point of 554 °C. Previously, the fabrication of BaS3 films was demonstrated, but in order to utilize them in the fabrication of BaZrS3 thin films, their microstructure and processing are further improved in this work by reducing the synthesis temperature to 300 °C, resulting in a smoother surface. This work lays the groundwork for future research in the fabrication of chalcogenide perovskites utilizing stacked layers and BaS3.
Effect of Traps on the UV Sensitivity of Gallium Oxide-Based Structures
Authors: Kalygina Vera M. , Tsymbalov Alexander V. , Korusenko Petr M. , Koroleva Aleksandra V. , Zhizhin Evgeniy V.
Published: March 2024

Resistive metal/β-Ga2O3/metal structures with different interelectrode distances and electrode topologies were investigated. The oxide films were deposited by radio-frequency magnetron sputtering of a Ga2O3 (99.999%) target onto an unheated sapphire c-plane substrate (0001) in an Ar/O2 gas mixture. The films are sensitive to ultraviolet radiation with wavelength λ = 254. Structures with interdigital electrode topology have pronounced persistent conductivity. It is shown that the magnitude of responsivity, response time τr, and recovery time τd are determined by the concentration of free holes p involved in recombination processes. For the first time, it is proposed to consider hole trapping both by surface states Nts at the metal/Ga2O3 interface and by traps in the bulk of the film.
Evaluating Novel Biomarkers for Personalized Medicine
Authors: Drugan Tudor , Leucuța Daniel
Published: March 2024

Personalized medicine, sometimes referred to as precision medicine, is a paradigm shift in healthcare [...]
Relationship between Bilateral Landmarks of Facial Asymmetry in Skeletal Class II and Class III in Vertical Dimension: 3D Facial Scan and Cone-Beam Computed Tomography
Authors: Jearanai Tanapat , Samruajbenjakun Bancha , Chanmanee Pannapat
Published: March 2024

Significant facial asymmetry can lead to both functional and aesthetic issues. Often, such asymmetry originates from irregularities in the jaw structure. It is critical to recognize that asymmetries can be concealed by soft tissue, which may be overlooked. The aim of this study is to investigate the relationships between bilateral landmarks in the vertical dimension of facial asymmetry among individuals with skeletal Class II and Class III malocclusions. Fifty-two adult patients with a mean age of 24.4 ± 3.79 years with facial asymmetry who underwent orthodontic and orthognathic surgery were studied. Cone-beam computed tomography and facial scans were used to create 3D virtual head models which enhanced the accuracy in addressing facial asymmetry to ensure effective treatment planning. Each landmark was measured and digitized using the Dolphin Imaging program. The findings showed a correlation between gender and type of skeletal discrepancies with the menton deviation direction. In conclusion, the vertical discrepancy between bilateral landmarks was observable in both hard and soft tissues with more pronounced expression in soft tissues. This discrepancy was characterized by an elevation on the same side as the menton deviation, which was a feature observed in both skeletal Class II and Class III individuals.
Performance Assessment of Sysmex DI-60: Is Digital Morphology Analyzer Reliable for White Blood Cell Differentials in Body Fluids?
Authors: Shin Eunju , Hur Mina , Kim Hanah , Lee Gun-Hyuk , Hong Mi-Hyun , Nam Minjeong , Lee Seungho
Published: March 2024

Background: Few studies have evaluated digital morphology (DM) analyzers on body fluids (BF). We evaluated the performance of a DM analyzer, Sysmex DI-60 (Sysmex, Kobe, Japan) for white blood cell (WBC) differentials in BF samples. Methods: In five BF samples (two pleural fluids and three ascites) containing a single, dominant cell type (>80%, neutrophils, lymphocytes, macrophages, abnormal lymphocytes, and malignant cells in each sample), we evaluated the precision of the DI-60 and compared the WBC differentials and turnaround times (TAT) between DI-60 and manual counting. Results: The precision of the DI-60 pre-classification and verification was excellent (%CV, 0.01–3.16%). After verification, the DI-60 showed high sensitivity, specificity, and efficiency (ranges: 90.8–98.1%, 96.8–97.9%, and 92.5–98.0%, respectively) for the dominant cell types in neutrophil- and lymphocyte-dominant samples. For all samples, the DI-60 and manual counting showed high correlations for major cell types (neutrophils, lymphocytes, macrophages, and others, r = 0.72 to 0.94) after verification. The agreement between the pre-classification and verification of the DI-60 was strong in the neutrophil-dominant sample (κ = 0.81). The DI-60 showed a significantly longer TAT (min: s) than manual counting for all samples (median TAT/slide: 6:28 vs. 1:53, p < 0.0001), with remarkable differences in abnormal lymphocyte- and malignant cell-dominant samples (21:05 vs. 2:06; 12:34 vs. 2:25). Conclusions: The DI-60 may provide reliable data in neutrophil- and lymphocyte-dominant BF samples. However, it may require longer times and higher workloads for WBC differentials especially in BF samples containing atypical cells. Further improvement would be needed before applying DM analyzers for routine clinical practice in BF analysis.
Ultrasound during Advanced Life Support—Help or Harm?
Authors: Goudie Adrian , Blaivas Michael , Horn Rudolf , Lien Wan-Ching , Michels Guido , Wastl Daniel , Dietrich Christoph Frank
Published: March 2024

Ultrasound is used in cardiopulmonary resuscitation (CPR) and advanced life support (ALS). However, there is divergence between the recommendations of many emergency and critical care societies who support its use and the recommendations of many international resuscitation organizations who either recommend against its use or recommend it only in limited circumstances. Ultrasound offers potential benefits of detecting reversable causes of cardiac arrest, allowing specific interventions. However, it also risks interfering with ALS protocols and increasing unhelpful interventions. As with many interventions in ALS, the evidence base for ultrasound use is weak, and well-designed randomized trials are needed. This paper reviews the current theory and evidence for harms and benefits.
Serum Pro-Inflammatory Cytokines and Leptin as Potential Biomarkers for Treatment Response and Toxicity in Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Authors: Alrehaili Amani A. , Gharib Amal F. , Bakhuraysah Maha M. , Alharthi Afaf , Alsalmi Ohud , Alsaeedi Fouzeyyah Ali , Alhakami Reem Ali , Alasmari Kamilah Ali , Mohammed Nuha , Elsawy Wael H.
Published: March 2024

Squamous cell carcinoma of the head and neck (HNSCC) is a globally prevalent form of cancer with significant morbidity and mortality rates. The present study examines the relationship of serum pro-inflammatory cytokines and leptin levels with the effectiveness of therapy in individuals with HNSCC and their potential role as biomarkers for treatment response and toxicity. Induction chemotherapy and concomitant chemoradiotherapy were evaluated for efficacy and safety in 52 individuals with HNSCC. Both response and toxicity were evaluated, and serum levels of pro-inflammatory cytokines Interlukin-1 beta (IL-1β), Interlukin-2 (IL-2), Interlukin-6 (IL-6), and Tumor Necrosis Factor-Alpha (TNF-α) and leptin were measured using enzyme-linked immunoassay before and after treatment. Before treatment, these measurements were made in comparison with a control group with 50 healthy people. The results showed that serum cytokines and leptin levels varied depending on the response to treatment, with patients who had a complete or partial response (PR) showing significant decreases in IL-1 β, IL-6, and TNF-α levels and significant increases in IL-2 and leptin levels after treatment, with an improvement in cachexia. These results imply that variations in serum pro-inflammatory cytokines and leptin levels are likely related to the therapeutic effectiveness in HNSCC and may act as biomarkers for treatment response.
Constrained Reweighting of Distributions: An Optimal Transport Approach
Authors: Chakraborty Abhisek , Bhattacharya Anirban , Pati Debdeep
Published: March 2024

We commonly encounter the problem of identifying an optimally weight-adjusted version of the empirical distribution of observed data, adhering to predefined constraints on the weights. Such constraints often manifest as restrictions on the moments, tail behavior, shapes, number of modes, etc., of the resulting weight-adjusted empirical distribution. In this article, we substantially enhance the flexibility of such a methodology by introducing a nonparametrically imbued distributional constraint on the weights and developing a general framework leveraging the maximum entropy principle and tools from optimal transport. The key idea is to ensure that the maximum entropy weight-adjusted empirical distribution of the observed data is close to a pre-specified probability distribution in terms of the optimal transport metric, while allowing for subtle departures. The proposed scheme for the re-weighting of observations subject to constraints is reminiscent of the empirical likelihood and related ideas, but offers greater flexibility in applications where parametric distribution-guided constraints arise naturally. The versatility of the proposed framework is demonstrated in the context of three disparate applications where data re-weighting is warranted to satisfy side constraints on the optimization problem at the heart of the statistical task—namely, portfolio allocation, semi-parametric inference for complex surveys, and ensuring algorithmic fairness in machine learning algorithms.
Musical Preferences among Students Aged 9–19: A Study on Musical Genres and Styles
Authors: Szabó Norbert , Földi Fanni , Oo Tun Zaw , Csizmadia Gábor , Józsa Krisztián
Published: March 2024

This study aimed to explore students’ musical genre preferences, exploring variations across gender and age groups in Hungary. Additionally, we investigated the relationships among the popularity of musical genres and connections between musical programs and related activities. With the help of stratified sampling, we examined the opinions of students aged 9–19 about each genre (N = 1159) using specific musical examples. In this study, musical genres were classified into four main types based on related music videos, including classical popular music (CPM), rock music (RM), classical art music (CAM), and folk music (FM). Different types of analyses, such as t-tests, one-way and two-way ANOVAs, and correlational analyses such as correlation coefficients (r), chi-square tests, and eta squares, were employed in this study. The results showed that the popularity of the four pieces of music classified as CPM, RM, CAM, and FM had a moderately strong correlation with each other. The correlations between FM, CPM, and RM did not differ from each other, but they showed significantly weaker correlation values than the correlation between FM and CAM. Moreover, significant differences were found in the students’ perceptions of the genres based on their gender and age groups. Among the four performances, the girls had a greater preference compared to the boys for each one, except for the folk music piece. The youngest age group (9–12) showed the highest preference for the CPM, although the difference compared to the oldest age group (17–19) was not statistically significant. Therefore, this study is beneficial for music education, focusing on students’ genre preferences, including CPM, RM, CAM, and FM.