bluuebunny/crossref_metadata_2025 huggingface dataset:
Extraction of Ursolic Acid from Apple Peel with Hydrophobic Deep Eutectic Solvents: Comparison between Response Surface Methodology and Artificial Neural Networks
Authors: Li Haiyan , Liu Yugang , Guo Shiyin , Shi Meng , Qin Si , Zeng Chaoxi
Published: January 2023

Extracting ursolic acid (UA) from plant resources using organic solvents is incompatible with food applications. To address this, in this study, 15 edible hydrophobic deep eutectic solvents (HDESs) were prepared to extract UA from apple peel, the extraction conditions were optimized, and the optimization strategies were compared. It was found that the solubility of UA in the HDESs can be 9 times higher than the traditional solvent such as ethanol. The response surface optimization concluded that temperature had the greatest effect on the extraction and the optimized test conditions obtained as follows: temperature of 49 °C, time of 32 min, solid–liquid ratio of 1:16.5 g/mL, respectively. Comparing the response surface methodology (RSM) and artificial neural networks (ANN), it was concluded that ANN has more accurate prediction ability than RSM. Overall, the HDESs are more effective and environmentally friendly than conventional organic solvents to extract UA. The results of this study will facilitate the further exploration of HDES in various food and pharmaceutical applications.
Non-Periodicity of Complex Caputo Like Fractional Differences
Authors: Fečkan Michal , Danca Marius-F.
Published: January 2023

Aspects related to non-periodicity of a class of complex maps defined in the sense of Caputo like fractional differences and to the asymptotical stability of fixed points are considered. As example the Mandelbrot map of fractional order is considered.
LFM Signal Parameter Estimation via FTD-FRFT in Impulse Noise
Authors: Liu Xuelian , Li Xuemei , Xiao Bo , Wang Chunyang , Ma Bo
Published: January 2023

LFM signals are widely applied in radar, communication, sonar and many other fields. LFM signals received by these systems contain a lot of noise and outliers. In order to suppress the interference of strong impulse noise on target signals and realize the accurate estimation of LFM signal parameters, the impulse noise of echo signals need to be filtered. In this paper, to solve the problem of poor performance of LFM signal parameter estimation based on fractional Fourier transform in impulse noise, alpha stable distribution is used to establish the mathematical model of impulse noise. The proposed fastest tracking differentiator with an adaptive tracking factor is used to suppress the strong impulse noise, and fractional Fourier transform is used to estimate the parameter of the LFM signals. The experimental results show that the proposed fastest tracking differentiator with an adaptive tracking factor has a good filtering performance. It can effectively filter the impulse noise in the echo signal and allows the FrFT method to accurate estimate the parameters of the LFM signals in strong impulse noise.
The Influence of Emulsifiers on the Physiochemical Behavior of Soy Wax/Rice Bran Oil-Based Oleogels and Their Application in Nutraceutical Delivery
Authors: Dhal Somali , Alhamidi Abdullah , Al-Zahrani Saeed M. , Anis Arfat , Pal Kunal
Published: January 2023

This research evaluated the influence of stearic acid, sunflower lecithin, and sorbitan monooleate on soy wax (SYW)/rice bran oil (RBO)-based oleogels. The physiochemical behavior of oleogel samples was evaluated using colorimetry, microscopy, FTIR, mechanical, crystallization kinetics, X-ray diffraction, and a drug release investigation. The prepared oleogels were light yellow, and adding emulsifiers did not change their appearance. All oleogels showed an oil binding capacity of >98%, independent of emulsifier treatment. The surface topography revealed that emulsifiers smoothed the surface of the oleogels. Bright-field and polarized micrographs showed the presence of wax grains and needles. FTIR spectra indicated that oleogel samples had the same functional group diversity as the raw materials. The oleogel samples lacked a hydrogen-bonding peak. Hence, we postulated that non-covalent interactions were involved in the oleogel preparation. According to stress relaxation studies, the firmness and elastic component of oleogels were unaffected by emulsifiers. However, EML3 (oleogel containing sorbitan monooleate) showed lower relaxing characteristics than the others. EML3 exhibited the slowest crystallization profile. Due to its low d-spacing, EML3 was found to have densely packed crystal molecules and the largest crystallite size. The in vitro drug release studies showed that emulsifier-containing oleogels dramatically affected curcumin release. These results may help customize oleogels properties to adjust bioactive component release in the food and pharmaceutical industries.
Development of Composite Edible Coating from Gelatin-Pectin Incorporated Garlic Essential Oil on Physicochemical Characteristics of Red Chili (Capsicum annnum L.)
Authors: Heristika Windy , Ningrum Andriati , Supriyadi Supriyadi , Munawaroh Heli Siti Helimatul , Show Pau Loke
Published: January 2023

Red chili is a climacteric fruit that still undergoes respiration after harvest. During storage, it is susceptible to mechanical, physical, and physiological damage and decay incidence, therefore a method is needed to protect it so that the quality losses can be minimized. One way this can be achieved is by applying edible coatings that can be made from hydrocolloids, lipids, or composites of both, in addition to antimicrobial agents that can also be added to inhibit microbial growth. In this study, we detail the application of an edible coating made of gelatin composite from tilapia fish skin, which has a transparent color and good barrier properties against O2, CO2, and lipids. To increase its physicochemical and functional qualities, it must be modified by adding composite elements such as pectin as well as hydrophobic ingredients such as garlic essential oil. This study was conducted to determine the effect of a gelatin–pectin composite edible coating (75:25, 50:50, 25:75), which was incorporated with garlic essential oil (2% and 3%) on the physicochemical properties of red chili at room temperature (±29 °C), RH ± 69%) for 14 days. The best treatment was the 50–50% pectin–gelatin composite, which was incorporated with garlic essential oil with a concentration of 2 and 3%. This treatment provided a protective effect against changes in several physicochemical properties: inhibiting weight loss of 36.36 and 37.03%, softening of texture by 0.547 and 0.539 kg/84 mm2, maintaining acidity of 0.0087 and 0.0081%, maintaining vitamin C content of 2.237 and 2.349 mg/gr, anti-oxidant activity (IC50) 546.587 and 524.907; it also provided a protective effect on chili colors changing to red, and retains better total dissolved solid values.
Emulsion Gels Formed by Electrostatic Interaction of Gelatine and Modified Corn Starch via pH Adjustments: Potential Fat Replacers in Meat Products
Authors: Asyrul-Izhar Abu Bakar , Bakar Jamilah , Sazili Awis Qurni , Goh Yong Meng , Ismail-Fitry Mohammad Rashedi
Published: January 2023

The application of emulsion gels as animal fat replacers in meat products has been focused on due to their unique physicochemical properties. The electrostatic interaction between proteins and polysaccharides could influence emulsion gel stability. This study aimed to evaluate the physicochemical properties of emulsion gels using starch and gelatin as stabilizers, promoting electrostatic attraction via pH adjustment. Three systems were studied: emulsion gel A (EGA) and emulsion gel B (EGB), which have positive and negative net charges that promote electrostatic interaction, and emulsion gel C (EGC), whose charge equals the isoelectric point and does not promote electrostatic interactions. There was no significant difference in proximate analysis, syneresis and thermal stability between samples, while EGA and EGB had higher pH values than EGC. The lightness (L*) value was higher in EGA and EGB, while the yellowness (b*) value was the highest in EGC. The smaller particle size (p < 0.05) in EGA and EGB also resulted in higher gel strength, hardness and oxidative stability. Microscopic images showed that EGA and EGB had a more uniform matrix structure. X-ray diffraction demonstrated that all the emulsion gels crystallized in a β′ polymorph form. Differential scanning calorimetry (DSC) revealed a single characteristic peak was detected in both the melting and cooling curves for all the emulsion gels, which indicated that the fat exists in a single polymorphic state. All emulsion gels presented a high amount of unsaturated fatty acids and reduced saturated fat by up to 11%. Therefore, the emulsion gels (EGA and EGB) that favored the electrostatic protein-polysaccharide interactions are suitable to be used as fat replacers in meat products.
Electron Beam Irradiation Cross-Linked Hydrogel Patches Loaded with Red Onion Peel Extract for Transdermal Drug Delivery: Formulation, Characterization, Cytocompatibility, and Skin Permeation
Authors: Uttayarat Pimpon , Chiangnoon Rattanakorn , Thongnopkoon Thanu , Noiruksa Kesinee , Trakanrungsie Jirachaya , Phattanaphakdee Wattanaporn , Chittasupho Chuda , Athikomkulchai Sirivan
Published: January 2023

The use of bioactive molecules derived from medicinal plants in wound healing has recently attracted considerable attention in both research and public interest. In this work, we demonstrated the first attempt to incorporate the extract from Thai red onion skins in hydrogel patches intended for transdermal delivery. The red onion skin extract (ROSE) was first prepared and evaluated for cytotoxicity by MTT assay with both L929 and human dermal fibroblast cells. Hydrogel patches with porous microstructure and high water content were fabricated from polyvinyl alcohol (PVA) by electron beam irradiation and characterized for their physical, mechanical, morphological, and cytocompatible properties prior to the loading of ROSE. After decontamination by electron beam irradiation, the in vitro release profile exhibited the burst release of extract from ROSE-coated hydrogel patches within 5 h, followed by the sustained release up to 48 h. Finally, evaluation of skin permeation using Franz cell setup with a newborn pig skin model showed that the permeation of ROSE from the hydrogel patch increased with time and reached the maximum of 262 µg/cm2, which was well below the cytotoxicity threshold, at 24 h. These results demonstrated that our ROSE-coated hydrogel patches could potentially be used in transdermal delivery.
Complete Mitochondrial Genome of Scolytoplatypodini Species (Coleoptera: Curculionidae: Scolytinae) and Phylogenetic Implications
Authors: Yu Guangyu , Lai Shengchang , Liao Song , Cao Yufeng , Li Weijun , Long Chengpeng , Tarno Hagus , Wang Jianguo
Published: January 2023

The complete mitochondrial genomes (mitogenomes) of beetles in the tribe Scolytoplatypodini (genus Scolytoplatypus) were sequenced and annotated. These included Scolytoplatypus raja (15,324 bp), Scolytoplatypus sinensis (15,394 bp), Scolytoplatypus skyliuae (15,167 bp), and Scolytoplatypus wugongshanensis (15,267 bp). The four mitogenomes contained 37 typical genes, including 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), and 2 ribosomal RNA genes (rRNAs). The gene orientation and arrangement of the four mitogenomes were similar to other Coleoptera mitogenomes. PCGs mostly started with ATN and terminated with TAA. The Ka/Ks ratio of 13 PCGs in the four species revealed that cox1 had the slowest evolutionary rate and atp8 and nad6 had a higher evolutionary rate. All tRNAs had typical cloverleaf secondary structures, but trnS1 lacked dihydrouridine arm. Partial tRNAs lost the discriminator nucleotide. The trnY did not possess the discriminator nucleotide and also lost three bases, showing a special amino-acyl arm. Bayesian inference (BI) and maximum likelihood (ML) methods were conducted for phylogenetic analyses using 13 PCGs. Scolytoplatypodini was clustered with Hylurgini and Hylastini, and the monophyly of Scolytoplatypodini was supported. The four newly sequenced mitogenomes increase understanding of the evolutionary relationships of Scolytoplatypodini and other Scolytinae species.
Genomic Regions Associated with Wool, Growth and Reproduction Traits in Uruguayan Merino Sheep
Authors: Ramos Zully , Garrick Dorian J. , Blair Hugh T. , Vera Brenda , Ciappesoni Gabriel , Kenyon Paul R.
Published: January 2023

The aim of this study was to identify genomic regions and genes associated with the fiber diameter (FD), clean fleece weight (CFW), live weight (LW), body condition score (BCS), pregnancy rate (PR) and lambing potential (LP) of Uruguayan Merino sheep. Phenotypic records of approximately 2000 mixed-age ewes were obtained from a Merino nucleus flock. Genome-wide association studies were performed utilizing single-step Bayesian analysis. For wool traits, a total of 35 genomic windows surpassed the significance threshold (PVE ≥ 0.25%). The proportion of the total additive genetic variance explained by those windows was 4.85 and 9.06% for FD and CFW, respectively. There were 42 windows significantly associated with LWM, which collectively explained 43.2% of the additive genetic variance. For BCS, 22 relevant windows accounted for more than 40% of the additive genetic variance, whereas for the reproduction traits, 53 genomic windows (24 and 29 for PR and LP, respectively) reached the suggestive threshold of 0.25% of the PVE. Within the top 10 windows for each trait, we identified several genes showing potential associations with the wool (e.g., IGF-1, TGFB2R, PRKCA), live weight (e.g., CAST, LAP3, MED28, HERC6), body condition score (e.g., CDH10, TMC2, SIRPA, CPXM1) or reproduction traits (e.g., ADCY1, LEPR, GHR, LPAR2) of the mixed-age ewes.
Gathering the Stakeholder’s Perspective: Experiences and Opportunities in Rare Genetic Disease Research
Authors: White Lauren K. , Crowley T. Blaine , Finucane Brenda , McClellan Emily J. , Donoghue Sarah , Garcia-Minaur Sixto , Repetto Gabriela M. , Fischer Matthias , Jacquemont Sebastien , Gur Raquel E. , Maillard Anne M. , Donald Kirsten A. , Bassett Anne S. , Swillen Ann , McDonald-McGinn Donna M.
Published: January 2023

Background: Research participant feedback is rarely collected; therefore, investigators have limited understanding regarding stakeholders’ (affected individuals/caregivers) motivation to participate. Members of the Genes to Mental Health Network (G2MH) surveyed stakeholders affected by copy number variants (CNVs) regarding perceived incentives for study participation, opinions concerning research priorities, and the necessity for future funding. Respondents were also asked about feelings of preparedness, research burden, and satisfaction with research study participation. Methods: Modified validated surveys were used to assess stakeholders´ views across three domains: (1) Research Study Enrollment, Retainment, Withdrawal, and Future Participation; (2) Overall Research Experience, Burden, and Preparedness; (3) Research Priorities and Obstacles. Top box score analyses were performed. Results: A total of 704 stakeholders´ responded from 29 countries representing 55 CNVs. The top reasons for initial participation in the research included reasons related to education and altruism. The top reasons for leaving a research study included treatment risks and side effects. The importance of sharing research findings and laboratory results with stakeholders was underscored by participants. Most stakeholders reported positive research experiences. Conclusions: This study provides important insight into how individuals and families affected with a rare CNV feel toward research participation and their overall experience in rare disease research. There are clear targets for areas of improvement for study teams, although many stakeholders reported positive research experiences. Key findings from this international survey may help advance collaborative research and improve the experience of participants, investigators, and other stakeholders moving forward.
Association between Genetic Variants and Peripheral Neuropathy in Patients with NSCLC Treated with First-Line Platinum-Based Therapy
Authors: de Jong Corine , Herder Gerarda J. M. , van Haarlem Simone W. A. , van der Meer Femke S. , van Lindert Anne S. R. , ten Heuvel Alexandra , Brouwer Jan , Egberts Toine C. G. , Deneer Vera H. M.
Published: January 2023

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, disabling side effect in non-small cell lung cancer (NSCLC) patients treated with platinum-based therapy. There is increasing evidence for associations between genetic variants and susceptibility to CIPN. The aim of this study was to further explore genetic risk factors for CIPN by investigating previously reported genetic associations. Methods: A multicenter prospective follow-up study (PGxLUNG, NTR NL5373610015) in NSCLC patients (stage II-IV) treated with first-line platinum-based (cisplatin or carboplatin) chemotherapy was conducted. Clinical evaluation of neuropathy (CTCAE v4.03) was performed at baseline and before each cycle (four cycles, every three weeks) of chemotherapy and at three and six months after treatment initiation. The relationship between 34 single nucleotide polymorphisms (SNPs) in 26 genes and any grade (grade ≥ 1) and severe (grade ≥ 2) CIPN was assessed by using univariate and multivariate logistic regression modelling. Results: In total, 320 patients were included of which 26.3% (n = 84) and 8.1% (n = 26) experienced any grade and severe CIPN, respectively. The GG-genotype (rs879207, A > G) of TRPV1, a gene expressed in peripheral sensory neurons, was observed in 11.3% (n = 36) of the patients and associated with an increased risk of severe neuropathy (OR 5.2, 95%CI 2.1–12.8, adjusted p-value 0.012). A quarter (25%, n = 9/36) of the patients with the GG-genotype developed severe neuropathy compared to 6% (n = 17/282) of the patients with the AG- or AA-genotype. Multivariate logistic regression analysis showed statistically significant associations between the GG-genotype (ORadj 4.7, 95%CI 1.8–12.3) and between concomitant use of paclitaxel (ORadj 7.2, 95%CI 2.5–21.1) and severe CIPN. Conclusions: Patients with the GG-genotype (rs879207) of TRPV1 have an almost 5-fold higher risk of developing severe neuropathy when treated with platinum-based therapy. Future studies should aim to validate these findings in an independent cohort and to further investigated the individualization of platinum-based chemotherapy in clinical practice.
Functional Characterization of a Phf8 Processed Pseudogene in the Mouse Genome
Authors: St-Germain Joannie , Khan Muhammad Riaz , Bavykina Viktoriia , Desmarais Rebecka , Scott Micah , Boissonneault Guylain , Brunet Marie A. , Laurent Benoit
Published: January 2023

Most pseudogenes are generated when an RNA transcript is reverse-transcribed and integrated into the genome at a new location. Pseudogenes are often considered as an imperfect and silent copy of a functional gene because of the accumulation of numerous mutations in their sequence. Here we report the presence of Pfh8-ps, a Phf8 retrotransposed pseudogene in the mouse genome, which has no disruptions in its coding sequence. We show that this pseudogene is mainly transcribed in testis and can produce a PHF8-PS protein in vivo. As the PHF8-PS protein has a well-conserved JmjC domain, we characterized its enzymatic activity and show that PHF8-PS does not have the intrinsic capability to demethylate H3K9me2 in vitro compared to the parental PHF8 protein. Surprisingly, PHF8-PS does not localize in the nucleus like PHF8, but rather is mostly located at the cytoplasm. Finally, our proteomic analysis of PHF8-PS-associated proteins revealed that PHF8-PS interacts not only with mitochondrial proteins, but also with prefoldin subunits (PFDN proteins) that deliver unfolded proteins to the cytosolic chaperonin complex implicated in the folding of cytosolic proteins. Together, our findings highlighted PHF8-PS as a new pseudogene-derived protein with distinct molecular functions from PHF8.
Strength and Bioelectrical Activity of the Pelvic Floor Muscles and Sexual Function in Women with and without Stress Urinary Incontinence: An Observational Cross-Sectional Study
Authors: Ferreira Clicia Raiane Galvão , Soares Wenderk Martins , da Costa Priante Caren Heloise , de Souza Duarte Natália , Soares Cleuma Oliveira , Bittencourt Kayonne Campos , Melo Giovana Salomão , Nunes Erica Feio Carneiro , de Campos Gomes Fabiana , De Melo Neto João Simão , Rodrigues Cibele Nazaré Câmara
Published: January 2023

Stress urinary incontinence (SUI) results from an increase in intravesical pressure, which exceeds the pressure at which the urethra remains closed. Symptoms cause social and sexual intercourse discomfort directly or indirectly, which affect health-related quality of life and are associated with pelvic floor muscle (PFM) dysfunction. We aimed to verify the variation in strength and PFM bioelectrical activity and sexual function in women with SUI. Additionally, we analyzed the impact of this dysfunction on quality of life. This was an observational cross-sectional study. Women aged 25–55 years with frequent sexual intercourse were included. Women with SUI were included in a study group (G2, n = 17), and those without any type of incontinence were included in a control group (G1, n = 16). Primary outcomes were level of strength and PFM bioelectrical activity and sexual function as determinants of worse SUI in the control group. Secondary outcomes were associated between the primary outcomes and severity of urinary loss, impact on daily life, and quality of life in women with SUI. In the domains evaluated in the Female Sexual Function Index (FSFI), only sexual desire was lower in women with SUI (G2) than in the controls (p = 0.033). During analysis of G1 variables, a positive and moderate correlation was observed between power/myoeletric activation and maximum voluntary contraction (MVC) (p < 0.01), peak (p < 0.01), and mean amplitudes (p = 0.017). There was a high positive correlation between sexual arousal and other variables, including vaginal lubrication, sexual orgasm, and total FSFI value (p < 0.001 for all analyses). During evaluation of G2 variables, the MVC was positively correlated with the peak and mean amplitudes (p < 0.0001). Additionally, there was a high and positive correlation between the mean amplitudes (%MVC) and personal relationships (KHQ) (p = 0.001); the same was observed between the total (ICIQ) and activities of daily living (ICIQ) (p < 0.0001). Therefore, women with SUI presented with lower sexual desire and bioelectric activity but were not related to PFM strength. Additionally, the domains of sexual function and certain variables of quality of life are aggravated by SUI.
Association between GHQ-12, Duke-UNC-11, Physical Activity, and Self-Perceived Health in Spanish Adults with Cancerous Tumours: A Cross-Sectional Study
Authors: Franco-García Juan Manuel , Denche-Zamorano Ángel , Pereira-Payo Damián , Rodríguez-Redondo Yeray , Carlos-Vivas Jorge , Castillo-Paredes Antonio , García-Gordillo Miguel Ángel , Muñoz-Bermejo Laura
Published: January 2023

Background: In Spain, people who have overcome some type of cancer have significantly worse self-perceived health (SPH) and higher rates of depression than people who have never suffered any type of cancer. Objective: to explore the relationships among physical activity levels (PAL), perceived social support (PSS), and SPH in terms of mental health and its dimensions in Spanish adults with cancerous tumours. Methods: A correlational study rooted in the National Health Survey 2017 for adults was carried out, including 627 Spanish residents who reported having malignant tumours. Results: A dependent association was found between PAL and SPH (p < 0.001). The mental health mean score decreased as PAL increased for the total sample and for both sexes, separately (p < 0.001). Low reverse associations were also observed between PAL and mental health (rho: −0.274; p < 0.001), successful coping (rho: −0.239; p < 0.001) and self-confidence (rho: −0.264; p <0.001). Moreover, PSS weakly and inversely correlates with mental health (r: −0.225; p < 0.001), successful coping (r: −0.218; p < 0.001) and self-confidence (r: −0.231; p < 0.001). A binary logistic model showed that active and very active people presented less threat of poor SPH, as did people with higher PSS (p < 0.001). Conclusions: Greater levels of physical activity are associated with larger mean scores in the three dimensions of mental health, perceived social support and self-perceived health in people with cancerous tumours.
Outcome Assessment after Reconstruction of Tumor-Related Mandibular Defects Using Free Vascularized Fibular Flap—A Clinical Study
Authors: Qayyum Zahid , Khan Zafar Ali , Maqsood Afsheen , Prabhu Namdeo , Saad Alqarni Mohammed , Bader Alzarea K. , Issrani Rakhi , Abbasi Maria Shakoor , Ahmed Naseer , Sghaireen Mohammed Ghazi , Heboyan Artak
Published: January 2023

The objective of this study was to analyze the outcomes of the free vascularized fibular flap in the reconstruction of mandibular defects, and to assess the oral health impact profile of these patients before surgery and after oral rehabilitation. Patients requiring reconstruction of defects greater than 6 cm were selected for this study. The defect size and type, the size of the required skin paddle, the need for second flaps, the intraoperative complications, and the type of closure were documented. Patients were evaluated postoperatively for function, aesthetics, and donor- or reconstruction-site complications. The validated oral health impact profile (OHIP-14) questionnaires were filled before and after surgery and after dental rehabilitation. This study included 11 cases of squamous-cell carcinomas, 2 cases of malignant nerve sheath tumors, and 1 case each of malignant melanoma, ameloblastoma, giant-cell tumor, osteosarcoma, and chondrosarcoma. The analysis revealed a significant association (p = 0.030) of gender with free vascular flap complications, while no significant association (p > 0.05) was found when donor- and recipient- site complications, as well as the type of resection (Brown’s classification), were compared with free vascular flaps. Moreover, the total OHIP-14 scores for patients before surgery, after surgery, and after dental rehabilitation were 12.03 ± 1.34, 10.66 ± 1.41, and 08.33 ± 0.62, respectively. The oral health-related quality of life was markedly improved after the reconstruction of the mandibular defects with free vascularized fibular flap and dental rehabilitation. The overall success rate of fibular flap in our study was 72.2%, which is lower than that reported in the literature. This may be attributed to the fact that almost all of our cases included large segmental defects that extended across the midline of the mandible.
The Evaluation of Clinical Signs and Symptoms of Malignant Tumors Involving the Maxillary Sinus: Recommendation of an Examination Sieve and Risk Alarm Score
Authors: Bashir Atif , Khan Zafar Ali , Maqsood Afsheen , Prabhu Namdeo , Saleem Muhammad Mudassar , Alzarea Bader K. , Issrani Rakhi , Khan Shammas Raza , Ahmed Naseer , Abbasi Maria Shakoor , Marya Anand , Sghaireen Mohammed Ghazi , Heboyan Artak
Published: January 2023

This observational study was conducted to evaluate the clinical signs and symptoms of maxillary sinus tumors and to propose a clinical examination sieve and a unique risk alarm score to be used for timely patient referral and vigilance. The study consisted of 70 patients between 20 to 82 years of age from both sexes. The clinical information gained was collected from the upper dentoalveolar segment, orbit, and nasal sites. Regarding the early clinical sign and symptoms of patients, nasal obstruction was found in 67 patients (95.7%), facial swelling in 69 patients (98.6%), paresthesia in 41 patients (58.6%), and epistaxis in 50 patients (71.4%). Furthermore, in terms of the late signs and symptoms, a palpable mass in buccal sulcus was observed in 65 (92.9%) of the patients, lymphadenopathy in 24 (34.3%), paresthesia in 38 (54.3%), and diplopia in 22 (31.4%). Furthermore, general sign and symptoms like exophthalmos was present in 35 patients (50%), anosmia was observed in 37 patients (52.9%), and oroantral fistula was noted in 37 patients (55.9%). Additionally, 67 (95.7%) of the patients complained of nasal obstruction. Similarly, facial asymmetry was observed in 69 (98.6%) of the patients and double vision was observed in 24 (34.4%). Tumors of the maxillary sinus have a very insidious course of spread and uncertain clinical signs and symptoms. What makes diagnosis worse is the fact that the symptoms of these tumors are so well hidden in the sponge-like nature of the midfacial region that they are easily misinterpreted by patients. Therefore, diagnoses must be made early, dentists must be vigilant, and patients must be fully investigated at the slightest suspicion of a tumor, albeit benign.
Global and Dimensions of Mental Health in Arthritis Patients
Authors: Kang Weixi
Published: January 2023

Arthritis is one of the main clusters of long-lasting musculoskeletal and joint disorders. Recently, there has been increasing interest in the impact of arthritis patients’ mental health, which has mainly focused on depression and anxiety in clinical samples. However, much less is known about how domains of mental health based on the widely used 12-item version of the general health survey (GHQ-12) are affected by arthritis. The current research answered this question using confirmatory factor analysis, general linear models, and one-sample t-tests on a nationally representative sample from the United Kingdom with 5588 arthritis patients and 8794 participants indicating that they were not clinically diagnosed with arthritis. The current study found that (1) a total of three factors of GHQ-12 that are labeled GHQ-12A (social dysfunction and anhedonia; six items), GHQ-12B (depression and anxiety; four items), and GHQ-12C (loss of confidence; two items), and (2) both the global mental health and dimensions of mental health are negatively affected by arthritis. Clinicians could use the results from the present study to make better treatment decisions for patients with arthritis.
Postpartum Depression and Anxiety among Lebanese Women: Correlates and Scales Psychometric Properties
Authors: Hobeika Eva , Malaeb Diana , Obeid Sahar , Salameh Pascale , Hobeika Elie , Outayek Miguella , Akel Marwan , Kheir Nelly , Sleiman Zaki , Barakat Habib , Hallit Souheil
Published: January 2023

Background: We found that it was important to fill a gap in the literature and check the psychometric properties of the Edinburgh Postnatal Depression Scale (EPDS) and Perinatal Anxiety Screening Scale (PASS) in the Arabic language and delineate factors associated with postnatal depression (PPD) and anxiety (PPA) among Lebanese women 4–6 weeks after delivery. Methods: This cross-sectional study carried out between July 2018 and March 2019 enrolled 295 participants who came for a postnatal checkup at four clinics. Results: The EPDS and PASS scales’ items converged over two- and four-factor solutions, explaining 62.51% and 53.33% of the variance, respectively (KMO EPDS = 0.816, αCronbach EPDS = 0.826; KMO PASS = 0.878, αCronbach PASS = 0.920; Bartlett’s test of sphericity p < 0.001). Higher postpartum anxiety (Beta = 0.256), higher postpartum insomnia (Beta = 0.079), having hypotension during pregnancy (Beta = 2.760), and having a second (Beta = 1.663) or a third baby or more (Beta = 2.470) compared with the first one were significantly associated with higher postpartum depression. Higher postpartum depression (Beta = 1.33) was significantly associated with higher postpartum anxiety, whereas having a baby through a planned pregnancy (Beta = −4.365) and having a baby who ate regularly (Beta = −3.639) were significantly associated with lower postpartum anxiety. Conclusion: Depression and anxiety prevalence rates in the Lebanese population were higher compared with other countries, which may be due in part to the differences in regional, social and environmental culture.
Transition from Natural to Early Synthetic Dyes in the Romanian Traditional Shirts Decoration
Authors: Petroviciu Irina , Teodorescu Iulia Claudia , Vasilca Silvana , Albu Florin
Published: January 2023

The traditional shirt (“ie”) is the most well-known element of Romanian anonymous textile art. Apart from aesthetic and utilitarian roles, it has strong symbolic significance, mainly through the colours used for decoration. Very recently, the traditional shirt with decoration over the shoulder (“ia cu altiță”) was introduced as a Romanian identity element as part of UNESCO heritage. Depending on the ethnographic area, the traditional shirt with decoration over the shoulder has acquired special expressive particularities over time. Particularly relevant is that from Valea Hârtibaciului, an area of Transylvania in the very centre of Romania. Although sober in appearance with large fields of white plain weave, it is discreetly decorated with elaborated embroidery on the sleeve bracelets, over the shoulders and neck. Even the colour range and decoration motifs remain unchanged in time, evolution in the materials used and a subtle transition from natural hues to more strident alternatives were observed in the late 19th and early 20th centuries. For the present study, samples were taken from representative objects in the collections of the ASTRA Museum, Sibiu and Ethnographical Museum, Brasov, documented as belonging to the area of Valea Hârtibaciului and dated in the museum archives as from the late 19th and early 20th century. The textile materials and the dyes used in the shirts’ embroidery were monitored. Fibre identification was made by optical microscopy and infrared spectroscopy (FTIR-ATR). Dye analysis was performed by liquid chromatography coupled with UV-Vis (diode array) detection, while some of the samples were also analysed by liquid chromatography coupled with mass spectrometric detection (LC-DAD-MS). Dyes were extracted from the fibres by acid hydrolysis. Identification was based on data collected on standards, dyes and dyed fibres. For the early synthetic dyes, a dedicated library of references was built, which includes information relative to the most relevant representatives used between 1850 and 1900, the ‘Helmut Schweppe list’. According to the study, in the last decades of the 19th century, natural dye sources such as dyer’s broom, madder, Mexican cochineal and indigoid dyes were gradually replaced by early synthetic dyes: fuchsine (1856), methyl violet (1861), synthetic alizarin (1871), brilliant green (1879), azo flavine 3R (1880), rhodamine B (1887) and others.
Modifying Walk-In Tunnels through Solar Energy, Fogging, and Evaporative Cooling to Mitigate Heat Stress on Tomato
Authors: Sharaf-Eldin Mohamed A. , Yaseen Zaher Mundher , Elmetwalli Adel H. , Elsayed Salah , Scholz Miklas , Al-Khafaji Zainab , Omar Genesia F.
Published: January 2023

Global warming is by far the most significant issue caused by climate change. Over the past few decades, heat stress has intensified into a serious issue that has a negative impact on crop production. Hence, it is crucial to modify cultivation systems to cope with this kind of stress, particularly in arid dry regions. In comparison to open-field cultivation, tomato production under protected cultivation techniques in walk-in tunnels that are suited for different farmers’ financial abilities was evaluated during the late summer season. The studied tunnels included a shaded net tunnel with natural ventilation, net tunnel with a fogging system and plastic tunnel with evaporative cooling (wet pad and fans). For the operation of fogging and evaporative cooling systems, solar energy was used as a sustainable, eco-friendly energy source. The results indicated that the solar energy system successfully operated the studied cooling systems. All studied protective cultivation techniques mitigated heat stress on tomato plant and improved the microclimate under walk-in tunnels. Moreover, evaporative cooling and fogging systems significantly increased plant leaf area, cell membrane efficiency and the contents of chlorophyll, relative water and proline compared to the net tunnel with natural ventilation. Furthermore, a marked reduction in physiological disorders was noticed. Improved physiological and biochemical parameters and limited physiological diseases led to higher fruit set, marketable fruit yield and total productivity. The percentage of marketable fruit yield increased by around 31.5% with an evaporative cooling system, 28.8% with a fogging system and 17% with a shaded net tunnel with no positive cooling as compared to an open field. However, the plants grown in open-field cultivation without protection significantly deteriorated from heat stress and had a high incidence of physiological disorders. The most incident physiological disorders were blossom-end rot, cracking, internal white tissues, sunscald, puffiness, blotchy ripening, cat face and exserted stigma. It is recommended to use a solar energy system to modify microclimate conditions through fogging or evaporative cooling under walk-in tunnels to ameliorate heat stress on grown tomato in the late summer season for higher fruit yield and fewer physiological disorders.
Microbial Control in Greenhouses by Spraying Slightly Acidic Electrolyzed Water
Authors: Bhakta Bubai , Yamane Shinzo , Bhakta Jatindra Nath , Ohnishi Kouhei
Published: January 2023

Slightly acidic electrolyzed water (SAEW) has strong bactericidal activity and is relatively safe compared to other disinfectants. In vitro exposure of Escherichia coli and Bacillus subtilis to SAEW at a chlorine concentration of more than 25 mg/L for 3 min completely killed bacterial cells. When SAEW was sprayed in a greenhouse at a chlorine concentration of around 30 mg/L, the viability of airborne microorganisms was significantly reduced. On the other hand, SAEW spray did not affect the growth of eggplant and cucumber plants in the greenhouse. SAEW spray did not influence microorganisms in the soil or the plant leaf surface. SAEW could be used as a substitute for tap water to increase the relative humidity during the daytime, which is expected to increase photosynthesis. SAEW spraying reduces airborne microorganisms and improves the environmental conditions in the greenhouse.
Shade-Induced Effects on Essential Oil Yield, Chemical Profiling, and Biological Activity in Some Lamiaceae Plants Cultivated in Serbia
Authors: Lalević Dragana , Ilić Zoran S. , Stanojević Ljiljana , Milenković Lidija , Šunić Ljubomir , Kovač Renata , Kovačević Dragan , Danilović Bojana , Milenković Aleksandra , Stanojević Jelena , Cvetković Dragan
Published: January 2023

Thyme, mint, and lemon balm were used to determine whether shading conditions could improve the yield, composition, antioxidant, and antimicrobial activity in plant essential oils (EOs) in comparison with non-shaded plants from an open field. The yield of the EOs of non-shaded thyme, mint, and lemon balm, was 3.44, 3.96, and 0.21 mL/100 g, respectively. Plants covered by nets produced different levels of EOs (3.46, 2.20, and 0.45 mL/100 g) after 120 min of hydrodistillation. The main components of the thyme essential oil are thymol (44.2–43.9%), γ-terpinene (18.3–16.8%), and p-cymene (16.5–17.4%). The predominant components of mint essential oil are piperitenone oxide (52.6–64.8%) and 1,8 cineole (25.9–16.3%), while lemon balm essential oil consists of the following main components: geranial (34.0–32.8%); neral (21.3–24.9%); and piperitenone oxide (17.2–16.7%). The EOs from non-shaded thyme and mint plants have the highest antioxidant activity (EC50 value 0.54 mg/mL and 3.03 mg/mL). However, shaded lemon balm showed a stronger antioxidant activity (EC50 3.43 mg/mL) than non-shaded plants (12.85 mg/mL) after 60 min of incubation. The EOs from all plants showed significant effects against Escherichia coli, Proteus vulgaris, Bacillus subtilis, Staphylococcus aureus, and Candida albicans. The most active EOs against most of the isolates originated from Thymus vulgaris L., plants. Adequate cultivation techniques, such as shading for Lamiaceae plants, has positive effects, especially in Melissa officinalis L. Shading can achieve a higher content and components in terms of the specific biological activity (antioxidant and microbial) of EOs.
Biogeography of Selected Spring Endemics in Texas Interglacial-Drought Refugia with Unexpected Insights from a Spring-Dependent Nematode Parasite
Authors: Worsham Mclean L. D. , Bond Alan , Gibson James Randy , Huffman David G.
Published: January 2023

The contemporary distribution of crenobiontic endemics in central Texas is enigmatic because only some springs are occupied by crenobionts despite other unoccupied springs having seemingly suitable habitats. In the absence of complete paleo-records, a cohesive and widely accepted explanation for this biogeography has eluded researchers for many years. We suggest that data on contemporary species with obligate coevolution, such as parasites with multiple obligate hosts in their life cycles, can help to fill intervening gaps in the paleo-record because the contemporary distribution of such a parasite indicates that its hosts cohabitated without interruption since the arrival of the parasite. To test this conjecture, we studied one such parasite endemic to a select few central Texas springs, Huffmanela huffmani. By studying the distribution of the intermediate host, geologic and paleo-climatic records, performing lab experiments with live animals, and examining archived museum specimens of the definitive hosts from the 1950s, we were able to test multiple predictions about how the distribution of H. huffmani became what it is today. Our results corroborate a narrative suggesting that several severe droughts since the Wisconsin glaciations are responsible for having sculpted the present-day distribution of central Texas crenobionts.
Intercomparison of Automated Near-Real-Time Flood Mapping Algorithms Using Satellite Data and DEM-Based Methods: A Case Study of 2022 Madagascar Flood
Authors: Li Wenzhao , Li Dongfeng , Fang Zheng N.
Published: January 2023

Numerous algorithms have been developed to automate the process of delineating water surface maps for flood monitoring and mitigation purposes by using multiple sources such as satellite sensors and digital elevation model (DEM) data. To better understand the causes of inaccurate mapping information, we aim to demonstrate the advantages and limitations of these algorithms through a case study of the 2022 Madagascar flooding event. The HYDRAFloods toolbox was used to perform preprocessing, image correction, and automated flood water detection based on the state-of-the-art Edge Otsu, Bmax Otsu, and Fuzzy Otsu algorithms for the satellite images; the FwDET tool was deployed upon the cloud computing platform (Google Earth Engine) for rapid estimation of flood area/depth using the digital elevation model (DEM) data. Generated surface water maps from the respective techniques were evaluated qualitatively against each other and compared with a reference map produced by the European Union Copernicus Emergency Management Service (CEMS). The DEM-based maps show generally overestimated flood extents. The satellite-based maps show that Edge Otsu and Bmax Otsu methods are more likely to generate consistent results than those from Fuzzy Otsu. While the synthetic-aperture radar (SAR) data are typically favorable over the optical image under undesired weather conditions, maps generated based on SAR data tend to underestimate the flood extent as compared with reference maps. This study also suggests the newly launched Landsat-9 serves as an essential supplement to the rapid delineation of flood extents.
The Empirical Analysis of Environmental Regulation’s Spatial Spillover Effects on Green Technology Innovation in China
Authors: Wang Xinyu , Chai Yuanze , Wu Wensen , Khurshid Adnan
Published: January 2023

Green technology innovation is one of the driving forces of industrial structure upgrading. This innovation is thought to be related to environmental regulation. The study uses panel data for 30 Chinese provinces and cities from 2009 to 2020 and presents a comprehensive research-based explanation of how environmental regulations impact green innovation. This study employs the spatial Durbin model to analyze the spillover effect of the region. The results show that the total impact of environmental regulations is 0.223%, of which the direct effect is 0.099%. This impact includes the effects of both formal and informal environmental regulation. It indicates that ecological regulations significantly enhance green technology innovation. Furthermore, the spatial spillover effect is significantly positive at the 1% level with a coefficient of 0.124. Such spillover effects represent a learning effect of regional environmental regulation. Based on the results, the study suggests a few policy measures based on the detailed outcomes.
Using Sensor Data to Identify Factors Affecting Internal Air Quality within 279 Lower Income Households in Cornwall, South West of England
Authors: Johnes Christopher , Sharpe Richard A. , Menneer Tamaryn , Taylor Timothy , Nestel Penelope
Published: January 2023

(1) Background: Poor air quality affects health and causes premature death and disease. Outdoor air quality has received significant attention, but there has been less focus on indoor air quality and what drives levels of diverse pollutants in the home, such as particulate matter, and the impact this has on health; (2) Methods: This study conducts analysis of cross-sectional data from the Smartline project. Analyses of data from 279 social housing properties with indoor sensor data were used to assess multiple factors that could impact levels of particulate matter. T-Tests and Anova tests were used to explore associations between elevated PM2.5 and building, household and smoking and vaping characteristics. Binary logistic regression was used to test the association between elevated particulate matter and self-reported health; (3) Results: Of the multiple potential drivers of the particulate matter investigated, smoking and vaping were significantly associated with mean PM2.5. Following multivariate analysis, only smoking remained significantly associated with higher mean concentrations. Properties in which <15 cigarettes/day were smoked were predicted to have PM2.5 concentrations 9.06 µg/m3 higher (95% CI 6.4, 12.82, p ≤ 0.001) than those in which residents were non-smokers and 11.82 µg/m3 higher (95% CI 7.67, 18.19, p ≤ 0.001) where >15 cigarettes were smoked; (4) Conclusions: A total of 25% of social housing properties in this study experienced levels of indoor PM greater than WHO guideline levels for ambient air pollution. Although there are many factors that impact air quality, in this study the main driver was smoking. This highlights the importance of targeting smoking in indoor environments in future smoking cessation and control policy and practice and of understanding how pollutants interact in the home environment. There is also a need for further research into the impact on indoor air quality of vaping, particularly due to the rise in use and uncertainty of its long-term impact.