bluuebunny/crossref_metadata_2025 huggingface dataset:
Nutritional Optimization of Muffins using Wheat, Bean and Quinoa Flour: A Strategy for Enhancing Protein Quality and Healthy Benefits
Authors: Bassett María Natalia , Acuña María Elina , Corral Lucrecia , Moreno Elvecia Carmen , Fernández Noelia Natalia , Rossi Analia Mabel , Marigliano Ana Clelia Gómez , Tereschuk María Laura
Published: November 2024

The objective of the present study was to elaborate muffins optimizing nutritional quality using protein complementation, with regionally produced underutilized ingredients. The theoretical protein quality of various mixtures was assessed using the "digestible essential amino acid score" (DIAAS) method, using the FAO standard requirements as a reference protein. A muffin was subsequently designed, formulated, and produced using the optimal ratio of wheat, bean, and quinoa flour mixture, and compared to a control made with 100% wheat flour. The proteins, fats, dietary fibre, ashes, and moisture were determined using AOAC methods. Height, texture, and colour were evaluated using a Vernier calliper, a TA-XT 2 plus Texturometer, and a Colour Quest XE spectrophotometer. Antioxidant activity was determined using the DPPH radical decolouration method, and total phenolic compounds were quantified using the Folin-Ciocalteu method. The sensory characteristics and global acceptability were also performed. Results showed that the moisture, protein, fat, fibre content, hardness, colour and the total phenol content (p < 0,05) of muffins are significantly different from each other. The partial replacement of wheat flour with quinoa and bean flours caused a decrease in muffin height while increasing hardness, total phenol content, protein and dietary fibre content. The elaborated muffin showed good sensory acceptance, scoring 6.4 on a 9-point hedonic scale, and achieved an acceptability index of 71%. Formulating this muffin with a good nutritional balance offers an effective way to incorporate beans and quinoa into regular diets, helping to prevent chronic non-communicable and deficiency diseases in vulnerable populations.
Design and Analysis of a Small Size Printed UWB Monopole Antenna with Quad Band Notch functionality using Dual Number of TVDS EBG Cell
Authors: Samanta Aditya Kumar , Mandal Tapan , Dey Rajesh , Singh Monika , Mahajan Rupali Atul
Published: November 2024

A small size microstrip fed ultra-wide bandwidth (UWB) antenna with quad band notch characteristics has been described in this paper. Band notch characteristics are achieved by loading dual number of two via double-slot type electromagnetic band gap (TVDS EBG) structures. The size of TVDS - EBG structure is less compared to other conventional EBG cells. Detailed parametric study, surface current distributions, input impedance and equivalent circuit model has been conducted to elucidate the operational mechanisms underlying notch band in the proposed antenna. The proposed antenna design has been put into practical use and measurement outcomes are portrayed to compare against simulation results that notable align well. Proposed design provides impedance matching from 2.91 to 11.62 GHz (for 2 ≤ VSWR) with successful suppression of WiMAX (3.300–3.700 GHz), WLAN (4.910–5.350 GHz, and 5.630–5.820 GHz) and X-band ITU (8.03–8.50 GHz). The measured far-field radiation patterns are stable and group delay is almost constant in the whole operating frequency band. Thus the compact antenna might be an excellent candidate for UWB utilization..
Quinoa Protein Hydrolysate as Potential Immunomodulators: Effects on Cytokine Production and Macrophage Activation
Authors: Rueda Julio , Lobo Manuel Oscar , Galdeano Carolina Maldonado , Samman Norma Cristina
Published: November 2024

The increasing demand for plant-based proteins, particularly quinoa (Chenopodium quinoa Willd.), has spotlighted its potential as a functional food ingredient due to its high-quality protein content and bioactive compounds and a range of health-promoting properties, including antioxidant, anti-inflammatory, and immunomodulatory effects. This study investigates the immunomodulatory potential of quinoa protein concentrate (QPC), quinoa protein hydrolysate (QPH), and a quinoa peptide fraction (QPF < 3kDa) in regulating cytokine production and activating macrophages. QPH was prepared via QPC alcalase hydrolysis, followed by ultrafiltration (QPF < 3 kDa). In vitro and ex vivo assays on BALB/c mice peritoneal and spleen macrophages were conducted to evaluate cytotoxicity, cytokine profiles induced (Interleukin (IL)-6, IL-10, Tumor Necrosis Factor (TNF)-α, Interferon (IFN)-γ), and phagocytic activity of macrophages. Results indicated that QPC and QPH showed no cytotoxic effects at protein concentrations ≤ 1000 µg/mL. QPH at1000 µg/mL increased the production of IFN-γ and TNF-α, while increasing IL-10 release, suggesting a balanced pro- and anti-inflammatory response. Furthermore, QPF significantly enhanced phagocytic activity in spleen macrophages, underscoring its role in systemic immune activation. These findings suggest quinoa-derived proteins and peptides hold promise as functional ingredients for immune health applications.
Early developmental milestones associated with tics and psychopathological comorbidity : An EMTICS study
Authors: Steinberg Tamar , Feldman-Sadeh Dana , Apter Alan , Bronstein Yael , Elfer Noa , Carmel Miri , Michaelovsky Elena , Weizman Avi , Nahon Matan , Horesh Danny , Morer Astrid , Delgar Blanca Garcia , Schrag Anette , Fennig Silvana , Hoekstra Pieter J. , Dietrich Andrea , Benaroya-Milshtein Noa
Published: November 2024

Background
Chronic Tic disorders (CTD) including Tourette Syndrome (TS), are associated with psychopathological comorbidities. Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and other comorbidities have been linked to delays in early developmental milestones. Few studies have investigated the relationship between early developmental milestones, tic severity, and related comorbidities.
Methods
383 participants aged 3–16 years (76.8%, n = 294 boys) with CTD from the baseline assessment of the European Multicenter Tics in Children Study (EMTICS), were evaluated for early developmental milestones (sitting, walking, first words, complete a sentence, bladder and bowel control), tic severity, tic-related functional impairment, obsessive-compulsive disorder (OCD), ADHD, oppositional defiant disorder (ODD) and suspected ASD. Data was collected using gold-standard self and clinician reporting instruments. Analyses included Pearson correlations and logistic regressions.
Results
Correlations between the acquisition of developmental milestones and tic severity or impairment were significant with small effect sizes (severity of motor tics and tic impairment were correlated with walking (r = .11), while vocal tics were correlated with first words (r = .12)). Logistic regression revealed that delayed acquisition of first words was significantly associated with ADHD, ODD and suspected ASD (Odds Ratio (ROR): 1-1.13, 1.05–1.21, 1.01–1.16, 1.04–1.22, respectively), while delayed walking acquisition was associated with OCD (ROR: 1.01–1.27).
Discussion
This study highlights the association between early developmental milestones and later psychopathological comorbidities in CTD patients. These findings emphasize the need for further research to distinguish between children with only tics and those with tics and psychopathological comorbidities, to improve early detection of individuals at risk.
Faecalibacterium Prausnitzii Extracellular Vesicles Regulating Macrophage Differentiation via Homologous Recombination Repair in Inflammatory Bowel Disease
Authors: Pan Yinya , Zhao Xinlu , Chen Qiongyun , Zhao Tao , Ma Yichun , Wu Hai , Xiang Ying , Jiang Ping , Li Wenjun , Yan Qiong , Mao Shangtao , Tao Yufei , wang Lei , Zhu Yun , Xu Guifang
Published: November 2024

Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation influenced by the depletion of beneficial gut microbiota, a critical factor in disease onset and progression. This study investigates the therapeutic potential of extracellular vesicles (EVs) derived from Faecalibacterium prausnitzii (F.p EVs), a commensal bacterium whose reduction is linked to IBD. Our research demonstrates that F.p EVs are preferentially taken up by macrophages, where they exert their anti-inflammatory effects through the enhancement of homologous recombination (HR) repair mechanisms. Specifically, F.p EVs upregulate the expression of key proteins involved in HR repair, such as BRCA1 and BRCA2, thereby reducing DNA damage and inhibiting the cGAS-STING pathway, which is central to the inflammatory response. This modulation of macrophage function results in decreased pro-inflammatory cytokine production and enhanced intestinal barrier integrity. By elucidating these mechanisms, our study provides a clear understanding of how F.p EVs can be used to target fundamental aspects of IBD pathology, laying the groundwork for the development of more effective and targeted therapies.
Decomposing the net fiscal position of migrants in Europe
Authors: Boffi Giacomo , Suari-Andreu Eduard , Vliet Olaf van
Published: November 2024

In this study, we are the first to employ the Oaxaca-Blinder decomposition to analyse the difference between the net fiscal positions of migrants and native-born individuals in 15 EU countries from 2007 to 2018. We combine EU-SILC cross-sectional data on individual background characteristics, personal income, and welfare benefits with OECD information on personal income taxes and social security contributions. Our findings reveal crucial determinants of the direct fiscal gap between migrants and natives. To varying degrees, age, education, and country effects are the largest contributors to the observed differential between the net fiscal positions of natives (more negative) and migrants (more positive). We observe important differences between intra-EU and extra-EU migrants. More specifically, education has a significant positive effect on the net fiscal position of intra-EU migrants, while it is nearly irrelevant for extra-EU migrants. By shedding light on the factors explaining differences in the net fiscal impact, our study offers valuable insights for policymakers aiming to design interventions to foster inclusivity and reduce inequality between migrants and natives in Europe.
Repurposing Doxycycline for the Inhibition of Monkeypox Virus DNA Polymerase: A Comprehensive Computational Study
Authors: Yousaf Muhammad Abrar , Michel Maurice , Khan Abeedha Tu-Allah , Noreen Misbah , Bano Saddia
Published: November 2024

The global spread of monkeypox, caused by the double-stranded DNA monkeypox virus (MPXV), has underscored the urgent need for effective antiviral treatments. In this study, we aim to identify a potent inhibitor for MPXV DNA polymerase (DNAP), a critical enzyme in the virus replication process. Using a computational drug repurposing approach, we performed a virtual screening of 1,615 FDA-approved drugs based on drug-likeness and molecular docking against DNAP. Among these, 1,430 compounds met Lipinski's rule of five for drug-likeness, with Doxycycline emerging as the most promising competitive inhibitor, binding strongly to the DNAP active site with a binding affinity of − 9.3 kcal/mol. This interaction involved significant hydrogen bonds, electrostatic interactions, and hydrophobic contacts, with Doxycycline demonstrating a stronger affinity than established antivirals for smallpox, including Cidofovir, Brincidofovir, and Tecovirimat. Stability and flexibility analyses through a 200 ns molecular dynamics simulation and normal mode analysis confirmed the robustness of Doxycycline binding to DNAP. Overall, our results suggest Doxycycline as a promising candidate for monkeypox treatment, though additional experimental and clinical studies are needed to confirm its therapeutic potential and clinical utility.
Lymphocyte levels in Crohn's disease patients in clinical remission are significantly lower than normal people
Authors: He Asi , Hu Tulan , Li Linzhen
Published: November 2024

Background and purpose
Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory bowel disease caused by multiple causes. Lymphocytes migration is involved in the pathogenesis of IBD. The purpose of this study was to evaluate whether there were differences in blood lymphocytes levels between IBD patients in clinical remission and normal people.
Patients and Methods:
A total of 94 Crohn's disease (CD) and 20 ulcerative colitis (UC) patients were included in this study. Ninety-four people who underwent physical examination in our hospital were randomly selected as controls. We analyzed whether there were differences in white blood cell count, neutrophil count, neutrophil percentage, lymphocyte count, lymphocyte percentage between CD patients, UC patients and normal people.
Results
There were significant differences in lymphocyte count (P<0.001), lymphocyte percentage (P<0.001) and neutrophil count (P = 0.038), neutrophil percentage (P<0.001) between CD patients and normal people, but no statistically significant differences in sex (P = 0.216), age (P = 0.745) and white blood cell count (P = 0.757). UC patients had significant differences in white blood cell count (P = 0.005), lymphocyte count (P = 0.010) and neutrophil count (P = 0.023), but no difference in lymphocyte percentage (P = 0.968) and neutrophil percentage (P = 0.461).
Conclusions
The white blood cell count of CD patients was not significantly different from that of normal people, but the lymphocyte count and lymphocyte percentage were significantly different from that of normal people. Similar results were not found in UC patients.
Posterior Alien Hand Syndrome in a Patient with Parieto-Occipital Infarction: A Rare Presentation Mimicking Anterior Variant Features
Authors: Elhaj Ammar , Abdalla Hadeel A.S , Elhassan Islam , Elhassan Mohamed , Mohamed Saga
Published: November 2024

Background
Alien hand syndrome (AHS) is a rare condition characterized by involuntary movements of a limb that the patient perceives as alien and is usually associated with anterior or posterior brain lesions. This case involved a unique posterior AHS overlapping with the anterior form.
Case Presentation:
A 76-year-old male patient presented to the emergency department with confusion agitation and involuntary movement of the right arm subsequent to a fall. His medical history included recurrent pulmonary embolism treated with edoxaban, diabetes, and hypertension. Initial CT imaging indicated chronic changes; nevertheless, within 24 hours, his symptoms intensified, and subsequent imaging demonstrated a left posterior circulation infarct (PCA). His uncontrollable arm movements resulted in a diagnosis of posterior alien hand syndrome (AHS).
Management and outcome:
Management involved the use of aspirin, temporary cessation of edoxaban, and agitation management with quetiapine. After confirming the stability of the infarction, edoxaban was reintroduced. This case underscores the difficulties in treating AHS and anticoagulation in a complicated stroke scenario.
Conclusion
This case underscores the varied manifestations of AHS variations, indicating a complicated interaction among anatomical regions. A multidisciplinary approach is crucial for the management of AHS, especially in instances with overlapping features.
Analysis of production well construction features in permafrost conditions
Authors: Zaitsev V. I. , Karpikov A. V.
Published: November 2024

The purpose of the research is to present the analysis results of construction and operation features of oil and gas wells in permafrost conditions. Considering the materials relevant to this topic, the method of comparative analysis is applied. The object of the research is technologies and equipment used for high-quality and fast construction of deep wells in permafrost conditions. As a result, complications and accidents occur due to the collapse of well walls, occurrence of caverns, stuck pipes, casing deformation and subsidence of wellhead equipment. It is noticed that the most unstable rocks in permafrost sections are located in the range of 0–200 m. The effect of temperature on thermal interaction intensity in the ”flushing agent – wellhead – drill (production) string” system is analyzed. It is found out that maintaining negative temperature of well walls is the main way to prevent complications while drilling in permafrost. The use of thermally insulating casing pipes to form a well conductor string is considered. The rotary method is specified as the main drilling method in the cryolithozone while auger without flushing is relevant for drilling for shaft direction. It is determined that drilling with the use of drilling fluids has to solve the problem of solution freezing prevention when flushing has been stopped continuously. Taking into account that the permafrost zone, as a rule, consists of loose, unstable rocks, the great importance is given to the duration of drilling under the conductor, which should last not more than 3 days. During this time, almost no complications occur when using high-quality clay mud with the temperature in the range from 0.5 to 2.5 °C. The real possibility of using a drilling fluid with a negative temperature as a cleaning agent, as well as the same with a positive temperature, but with the use of additional special technologies, is investigated. The use of drilling fluids with a negative temperature is recornized to be not economical. It is specified that prevention of permafrost rock thawing requires not only pre-cooling of the circulating solution but also selection of increased values of the rotation frequency and axial load on the bottomhole with a simultaneous change in the amount of fluid supplied to the well when designing the drilling mode. Consideration is given to the implementation options of the drilling technology based on increasing mineralization degree of drilling fluids. A conclusion is drawn that “well – rock” system is in isotonic equilibrium if the mineralization degree of drilling fluids and pore water of permafrost rocks is the same.
Current state of subglacial rock core drilling technologies
Authors: Shadrin V. S. , Klimov V. Ya. , Bolshunov A. V.
Published: November 2024

The purpose of the study is to make an overview of subglacial rock core drilling projects on Arctic and Antarctic islands, which have been carried out by the experts from Russia, the United States of America, Denmark and China. By analyzing the outcomes of Russian and international projects, it was possible to pinpoint the technical and geological aspects of subglacial core drilling, as well as the benefits and drawbacks of the various technologies employed. Additionally, it was possible to identify the best kind of rock-cutting tool and identify a potential direction for further advancement of currently available technologies.The authors propose to consider a method for drilling basal ice and subglacial rocks, which is based on the principle of reciprocating rotary motion of the rock-cutting tool. The first evaluation test of the method under discussion was carried out more than ten years ago at Saint Petersburg Mining University and the results were encouraging. However, the researches dealt mainly with the processes occurring in the electromechanical drive rather than rock drilling modes. The authors of the article intend to carry out a series of studies with the goal of developing a core drilling method based on the reciprocating rotary motion of the rock-cutting tool for wells in subglacial rocks.
3d gravity from Virasoro TQFT: Holography, wormholes and knots
Authors: Collier Scott , Eberhardt Lorenz , Zhang Mengyang
Published: November 2024

We further develop the description of three-dimensional quantum gravity with negative cosmological constant in terms of Virasoro TQFT formulated in our previous paper [SciPost Phys. 15, 151 (2023)]. We compare the partition functions computed in the Virasoro TQFT formalism to the semiclassical evaluation of Euclidean gravity partition functions. This matching is highly non-trivial, but can be checked directly in some examples. We then showcase the formalism in action, by computing the gravity partition functions of many relevant topologies. For holographic applications, we focus on the partition functions of Euclidean multi-boundary wormholes with three-punctured spheres as boundaries. This precisely quantifies the higher moments of the structure constants in the proposed ensemble boundary dual and subjects the proposal to thorough checks. Finally, we investigate in detail the example of the figure eight knot complement as a hyperbolic 3-manifold. We show that the Virasoro TQFT partition function is identical to the partition function computed in Teichmüller theory, thus giving strong evidence for the equivalence of these TQFTs. We also show how to produce a large class of manifolds via Dehn surgery on the figure eight knot.
Analyzing the impact of viral marketing on brand equity dimensions in Egypt’s home appliances sector: A customer and legal perspective
Authors: Awad Abdelrehim , Moustafa Aldabousi Ahmed
Published: November 2024

In the digital age, viral marketing has emerged as a key driver in shaping brand equity, particularly in the highly competitive Egyptian home appliances sector. Traditional marketing strategies have proven insufficient in reaching consumers with the same efficacy as viral campaigns, which leverage digital platforms and consumer networks. This study examines the influence of viral marketing on brand equity dimensions – brand awareness, perceived quality, brand loyalty, and brand association – through the lens of both customer perception and legal frameworks Using a quantitative research design, data were collected from 270 respondents across 389 companies, with a response rate of approximately 70% of the total population in Egypt’s home appliances sector, with simple linear regression analysis employed to assess the relationships. The results indicate a strong positive effect of viral marketing on brand equity. Specifically, viral marketing accounts for 27.2% of the variance in brand awareness (R² = 0.272, p < 0.001), 28.1% in perceived quality (R² = 0.281, p < 0.01), 13.6% in brand loyalty (R² = 0.136, p < 0.05), and 40.9% in brand association (R² = 0.409, p < 0.001). Furthermore, the study finds that regulatory compliance plays a moderating role, ensuring that viral marketing campaigns remain within ethical and legal bounds, thereby enhancing consumer trust and the long-term impact of marketing efforts.These findings highlight the strategic value of integrating viral marketing with a firm understanding of legal frameworks to optimize brand equity in Egypt’s home appliances industry. This research provides actionable insights for brand managers and marketers looking to maximize the efficacy of their viral campaigns while maintaining brand integrity.
AcknowledgmentThe authors are thankful to the Deanship of Graduate Studies and Scientific Research at University of Bisha for supporting this work through the Fast-Track Research Support Program.
The evaluation of the effectiveness of bacterial lysate in preoperative preparation of children with adenotonsillar pathology
Authors: Drozdova M. V. , Larionova S. N. , Shapovalov L. E.
Published: November 2024

In childhood, the occurrence and steady growth of diseases of the nasopharyngeal tonsils, often acquiring a chronic course and occurring with exacerbations and complications, is facilitated by a number of factors. Etiological factors of adenotonsillar diseases in children are both bacterial and viral pathogens, among which respiratory viruses are among the most significant. Herpes virus infections (HVI) play an important role in the development of chronic upper respiratory tract pathology, especially in the cohort of frequently ill children. Representatives of the herpes virus family are characterized by lymphotropic action, long-term persistence in the body, and a tendency to reproduce in cells, leading to a violation of the immune status. The incidence of relapses in the postoperative period during surgical interventions in the ENT organs in children remains high. Herpesvirus etiology of recurrent infectious and inflammatory diseases of the URT (upper respiratory tract) is the leading factor in the ineffectiveness of tonsillotomy, adenotomy, and repeated proliferation of lymphoid tissue in the postoperative period in preschool children. The use of a drug from the group of bacterial lysates before surgery is justified in the treatment of frequently and long-term ill children with adenotonsillar hypertrophy.
Use of blue laser in a patient with postop restenosis of the choana after multiple surgical interventions for congenital choanal atresia
Authors: Asmanov A. I. , Pivneva N. D.
Published: November 2024

One of the most common complications following surgical interventions in nasal cavity is synechiae and scarring, which often leads to restenosis, particularly in cases of choanal atresia. Laser technologies, especially blue laser (wavelength 445 nm), represent a promising opportunity in rhinology for addressing these complications. Objective: to study the effectiveness and safety of blue laser for nasal synechiae and stenosis surgery in patients with congenital choanal atresia after multiple surgical interventions. In ENT department of Veltishev Institute 4 children have undergone choanal reconstruction following multiple attempts of choanoplasty. A clinical case of a 6-year-old girl diagnosed with bilateral complete choanal atresia, who underwent six surgical interventions within two years and was admitted with complete choanal restenosis is presented. The most common cause of restenosis after surgery for hoan atresia is the formation of synechiae in the surgical area. Traditional dissection of the synechiae in most cases leads to repeated stenosis. To reduce the recurrence rate in the patient, the authors used a blue laser. The blue laser demonstrated high effectiveness in the surgical treatment of postop restenosis, minimizing surgical trauma, preventing recurrences, and improving the patient’s quality of life. The results confirm the feasibility of using lasers in rhinology as a preferred method for treating restenosis and enhancing respiratory function.
Features of management of patients with seasonal allergic rhinitis
Authors: Vladimirova T. Yu. , Martynova A. B.
Published: November 2024

Introduction. Seasonal allergic rhinitis continues to be one of the most common chronic diseases, affecting up to 24% of the adult population of the Russian Federation.

Aim. To evaluate the effectiveness of the drug mometasone furoate (Nozefrin Allergy) in patients with seasonal allergic rhinitis in outpatient practice.

Materials and methods. The study was conducted in a group of 42 patients aged 18 to 73 years (average age 39.0 ± 15.5 years) diagnosed with seasonal allergic rhinitis. All patients received monotherapy with Nozefrin Allergy, 2 injections (50 mcg of mometasone furoate each) into each nostril once a day for 30 days. The effectiveness of the treatment was determined on the 7th, 14th, 30th day of treatment and on the 60th day.

Results and discussion. During the use of the drug Nozefrin Allergy, by the 7th day there was a significant decrease in complaints of impaired smell by 3.6 times, sneezing by 2.4 times, discharge from the nasal cavity decreased by 2.3 times, and nasal congestion by 2.3 times. 2.1 times. After 14 days, nasal congestion disappeared in 64.3%, nasal discharge and itching in the nasal cavity were absent in 69.0% and 88.1% of patients. According to the SST-12 test, already by the 7th day of using the drug Nozefrin Allergy, there was an increase in the average total score to 10.1 ± 1.9 points, which corresponds to normosmia. At days 14, 30, and 60, the mean total SST-12 score remained stable at 10.6 ± 0.9 points, 10.9 ± 1.1 points, and 11.1 ± 0.5 points, respectively. The dynamics of respiratory function at the end of the course of treatment was characterized by an improvement

in the total volumetric flow to 783.4 ± 162.7 cm3/s and a decrease in nasal resistance to 0.2 ± 0.1 cPa/ml. The total rTNSS scale score by the 7th day decreased to 9.1 ± 0.4 points, the severity of the assessed complaints was moderate.

Conclusion. The data obtained indicate the effectiveness of using the drug Nozefrin Allergy in patients with seasonal allergic rhinitis in outpatient clinical practice.
Pediatric masks of obstructive sleep apnea syndrome
Authors: Isachenko V. S. , Shapovalov L. E. , Drozdova M. V. , Larionova S. N.
Published: November 2024

A number of factors contribute to the occurrence of chronic otolaryngological diseases in children at an early age, which often acquire a long, undulating course with exacerbations, relapses and complications. The increasing aggressiveness of environmental factors, the growth of allergization of the population, the formation of strains of microorganisms resistant to the action of medicines, lead to a steady increase in diseases of the nasopharyngeal tonsils and a worsening of their course, especially among children, both in our country and abroad. At the same time, the adenotonsillar problem has long gone beyond ENT pathology and attracts the attention of a wide range of medical resea. The aim of the work: to analyze the literature data on clinical manifestations, laboratory and instrumental diagnostic methods and the prevalence of OSA in children. The analysis of publications using PubMed, EMBASE and Web of Science search engines in the period from January 1970 to March 2024 related to research on epidemiological, pathogenetic, clinical and laboratory aspects of OSA in children and adults was carried out. rchers. Sleep respiratory disorder is a term covering various clinical diagnoses from primary snoring to obstructive sleep apnea. This clinical symptom is registered in at least one in nine children, which makes it one of the most frequently diagnosed sleep disorders and puts it in the category of serious social problems. The most compelling evidence relates to hyperactivity, inattention, and social problems: decreased social competence, increased problematic behavior, and decreased memory scores. Despite the growing body of evidence suggesting cognitive impairment in children with snoring, many results have been contradictory. The availability of pediatric sleep laboratories, even in countries with advanced health systems, is limited, which encourages the search for less complex and more convenient testing methods. Timely detection of the development of the disease allows you to prevent complications and improve the quality of life. The article also describes clinical cases of late diagnosis of obstructive sleep apnea in children.
Acute purulent otitis media: key features of pathogenetic therapy
Authors: Gurov A. V. , Muzhichkova A. V. , Yushkina M. A.
Published: November 2024

Acute purulent otitis media is an inflammation of the mucous membrane of the middle ear, a disease often encountered both in pediatric practice and in adult patients. The prerequisite for the development of this pathology is a violation of the function of the auditory tube, often occurring in inflammatory diseases of the upper respiratory tract, as well as in conditions of hypertrophy of the pharyngeal tonsil. Bacterial microflora, represented in most clinical cases by S. pneumoniae and H. influenzae, traditionally acts as an etiological factor of acute purulent otitis media. The authors of the article discuss the features of the clinical course of the disease, the causes of frequent recurrent course and the risk of developing purulent complications. The article highlights current problems of diagnosis and treatment of acute otitis media at different stages, including rational and justified use of antibacterial drugs. The authors consider the possibility of using topical anti-inflammatory and analgesic drugs as an alternative to the systemic use of non-steroidal anti-inflammatory drugs (NSAIDs) for rapid relief of the main symptoms of the disease. The authors conclude that ear drops containing lidocaine and phenazone, due to their combined action, are effective as a symptomatic treatment for acute otitis media, including its recurrent course, help reduce the frequency of prescribing antibacterial drugs, effectively relieve pain, reduce the duration of the disease and significantly improve the patient’s quality of life. Due to the high safety profile and the possibility of using ear drops with phenazone and lidocaine from birth, this dosage form finds its successful application in pediatric practice.
Estudo Prospectivo sobre Biomassa Algal: Identificação de Oportunidades para Fortalecimento da Bioeconomia Brasileira
Authors: Anjos Sérgio Saraiva Nazareno dos , Viana Natália Moreno , Mendonça Simone , Cançado Letícia Jungmann , Damaso Mônica Caramez Triches
Published: November 2024

As microalgas e as cianobactérias são versáteis para diversos segmentos industriais, sendo insumos importantes para o fortalecimento da bioeconomia e para garantir a sustentabilidade de processos agroindustriais ao promover o uso racional do capital natural. A grande diversidade de mercados que podem ser contemplados pela exploração de microalgas e cianobactérias sinaliza a necessidade de investigar aspectos positivos e negativos do mercado brasileiro para impulsionar o mercado. O objetivo deste trabalho foi, pela aplicação do método Delphi de consulta a especialistas, identificar oportunidades científicas e tecnológicas para exploração de microalgas e cianobactérias no Brasil nos próximos dez anos. Segundo os especialistas consultados, os gêneros de maior destaque são Arthrospira sp., Chlorella sp., e Dunaliella sp. para os mercados farmacêutico/cosmético e de alimentação e suplementação animal. O Brasil tem grande potencial para se destacar no mercado de microalgas e cianobactérias, conforme já existe para outros microrganismos. No entanto, há empecilhos para explorar o potencial industrial das microalgas e cianobactérias para incluir o Brasil no mercado internacional a preços competitivos, dentre eles a baixa disponibilidade de recursos financeiros para investimentos em pesquisa, desenvolvimento e inovação e a escassez de profissionais para escalonamento de cultivo para oferta de biomassa.
Descarte Industrial e Domiciliar de Fármacos: Uma Revisão dos Impactos Socioambientais e Bases Legais Brasileiras
Authors: Lourencetti Cleonice , Dias Lucas Danilo
Published: November 2024

O descarte de fármacos pelas indústrias farmacêuticas e pela sociedade é considerado um problema sanitário, gerador de um enorme custo financeiro aos setores públicos e privados, bem como é responsável por diversos danos ambientes. Este estudo revisa criticamente a literatura recente sobre o descarte inadequado de medicamentos, com foco nos impactos ambientais e sociais, causas, abordagem legal e práticas mitigadoras. Neste sentido, foi realizada uma revisão narrativa da literatura,através de pesquisas bibliográficas e documental de leis, regulamentações e normas relativas à gestão de medicamentos, bem como da análise de estudos em forma de artigos publicados em periódicos acadêmicos. Enfatizamos a necessidade de conscientização e práticas sustentáveis. Através dos dados obtidos e analisados, destacamos a importância da conscientização, da implementação efetiva da logística reversa e do aprimoramento da legislação para mitigar os impactos socioambientais do descarte inadequado de medicamentos.
Coleta Seletiva em Frutal-MG: Analise da Atuação da Ascafru, Catadores e Moradores
Authors: Tomaz Rogério Fontes , Costa Gustavo Henrique Gravatim
Published: November 2024

A coleta seletiva é essencial para a preservação do meio ambiente, reduzindo a quantidade de resíduos destinados aos aterros sanitários, promovendo a reciclagem de materiais e contribuindo para a economia circular. Ao separar e destinar corretamente os resíduos, evita-se danos ambientais, reduz-se a extração de recursos naturais, gera-se empregos na cadeia de reciclagem, além de promover a sustentabilidade. O trabalho realizado teve como objetivo analisar a dinâmica da coleta seletiva e gestão de resíduos sólidos em Frutal-MG, com foco na atuação da Associação dos Catadores de Recicláveis do Município de Frutal (ASCAFRU), dos catadores associados e dos moradores do Bairro Princesa Isabel I. A pesquisa ocorreu em 2023, envolvendo gestores da associação, catadores e moradores. A coleta de dados foi realizada através de entrevistas e questionários estruturados. Os principais resultados indicaram a eficácia da coleta seletiva setorizada pela ASCAFRU, destacando a comercialização de materiais como metal, vidros, papelão e isopor. Os catadores, em sua maioria do gênero feminino e com baixa escolaridade, expressaram necessidade de capacitação digital e melhorias nas condições de trabalho. Já os moradores apresentaram parcial separação de resíduos e indicaram a falta de um cronograma eficaz de coleta como desafio. A interação entre catadores, moradores e órgãos públicos foi destacada como essencial para fortalecer a sustentabilidade ambiental e promover uma cultura de reciclagem. Reconhecendo o papel dos catadores, promovendo a educação ambiental e facilitando a separação de recicláveis, é possível fortalecer a prática da reciclagem na região.
A Pegada Ecológica como Instrumento para Análise do Perfil Ambiental de Alunos do Curso de especialização em Engenharia Sanitária Ambiental
Authors: Dias Isabela Alves , Lamim-Guedes Valdir , Mol Marcos Paulo  Gomes
Published: November 2024

Este artigo descreve a aplicação da Pegada Ecológica, no contexto de estudantes de um curso de pós-graduação lato sensu em Engenharia Sanitária Ambiental, entre 2017 e 2018, de uma instituição privada localizada em Belo Horizonte, Minas Gerais. Cada um dos 21 alunos participantes calculou a sua pegada ecológica e identificou qual hábito estava interferindo mais no valor encontrado, discutindo em sala os resultados. A pesquisa verificou a média do grupo (2,5 planetas necessários). O resultado do grupo ficou abaixo da média brasileira de 2,7, em 2007, e de algumas grandes cidades do país. Os indicadores que mais influenciaram foram a alimentação (39,2%) e o transporte (20,2%). Verificou-se a importância da aplicação desse método em sala de aula, em particular em uma disciplina de Educação Ambiental, que permitiu a sensibilização dos participantes, bem como a indicação de uma ferramenta importante para a conscientização das pessoas visando modificar seus hábitos de consumo.
O Papel do Artesanato Sustentável na Promoção do Desenvolvimento Socioeconômico em Comunidades Locais Brasileiras: Desafios Enfrentados pelos Artesãos
Authors: Cordeiro Eliete de Castro , Vigário Patrícia dos Santos
Published: November 2024

O presente levantamento bibliográfico teve como objetivo analisar o papel do artesanato sustentável na promoção do desenvolvimento socioeconômico em comunidades locais brasileiras. Para tal, foram consultadas as bases de dados Scientific Electronic Library Online (Scielo), Domínio Público, Periódicos CAPES e Google Acadêmico, utilizando as seguintes palavras-chave em uma busca avançada: “artesanato sustentável”, “artesãos” e “desenvolvimento sustentável”. Como resultados, constatou-se que os desafios a serem superados pelos artesãos de comunidades locais brasileiras para que o desempenho de seus ofícios se dê de forma sustentável com vistas ao desenvolvimento socioeconômico são muitos, e incluem a falta de incentivo governamental, a necessidade de fortalecimento das políticas públicas, e a ausência de comprometimento da coletividade no trato com a produção artesanal. Dessa forma, os resultados aqui encontrados podem contribuir para discussões e reflexões acerca das políticas públicas atuais, assim como o desenvolvimento de práticas que promovam o equilíbrio entre crescimento econômico, bem-estar social e sustentabilidade ambiental nas comunidades locais brasileiras. Por fim, é oportuno destacar que este tema está relacionado direta e indiretamente aos Objetivos de Desenvolvimento Sustentável (ODS) números 1, 8, 11, 12, 15 e 17 da Agenda 2030 das Nações Unidas (ONU) em prol de um mundo mais justo e sustentável.
Associação de Valeriana officinalis L. E Passiflora incarnata L. para Tratamento da Ansiedade ao Tratamento Odontológico
Authors: Deus Lara Borges de , Ribeiro Thaynara Liss Costa , Farias Ana Clara Lima de , Paz e Silva Andressa Cavalcante , Reis Liliane Braga Monteiro dos , Mariano Júnior Wilson José , Rosseto Lucimar Pinheiro
Published: November 2024

Procedimentos odontológicos podem provocar ansiedade, nervosismo e medo. Assim, é crescente a prescrição de medicamentos que atuam no controle da ansiedade pelos cirurgiões-dentistas. As plantas medicinais, tais como, Valeriana officinalis L. e a Passiflora incarnata L., são conhecidas por possuírem propriedades ansiolíticas e sedativas, no entanto, observa-se, na literatura, uma escassez de estudos clínicos sobre o uso de fitoterápicos na área da Odontologia. Neste sentido, esta pesquisa tem como objetivo verificar a eficácia da utilização de V. officinalis L. e P. incarnata L. (associadas) para a redução da ansiedade em pacientes odontofóbicos. Trata-se de um ensaio clínico prospectivo, randomizado e duplo cego. A escala Dental Anxiety Scale (DAS), de Corah, foi utilizada para identificar os pacientes com medo e ansiedade ao tratamento odontológico. Os pacientes classificados como moderadamente ou extremamente ansiosos ingeriram uma cápsula da associação de Passiflora [300 mg]/Valeriana [100mg] ou placebo (grupo controle), uma hora antes de serem submetidos ao procedimento odontológico. Também, aplicou-se um questionário socioeconômico, e foram aferidas a frequência cardíaca, pressão arterial e saturação de oxigênio dos participantes. De 146 pacientes, 65,1% eram mulheres e 34,9% homens. A prevalência de ansiedade nas mulheres foi maior que nos homens. Na comparação do escore de ansiedade antes e depois do tratamento odontológico, houve diferença estatisticamente significativa para aqueles que utilizaram os fitoterápicos quando comparados aos que receberam placebo. O uso associado de Valeriana officinalis L. e Passiflora incarnata L. foi eficaz em pacientes avaliados com grau moderado e severo de ansiedade, sendo, também, uma opção terapêutica aos benzodiazepínicos, comumente utilizados.
Indigenous Knowledge and Sustainable Resource Management - A Bibliometric Review
Authors: Borolla Fridolin Vrosansen , Rahmayanti Henita , Hidayat Otib Satibi , Abdullah Khairul Hafezad
Published: November 2024

The centuries-old methods of Indigenous cultures can help us manage resources sustainably and live in harmony with the environment. This study aims to identify publication trends on Indigenous knowledge and sustainable resource management. The current bibliometric review employed Scopus and Web of Science (WoS) datasets and analysed using ScientoPy and VOSviewer to discover the publications’ trends. The results of this review identified that the evolution of publications fluctuated and that the initiative to increase the research on this topic is crucial. Based on keywords analysis, this study found that “Ethnobotany” and “Climate Change” are used differently, highlighting the growing importance of Indigenous viewpoints in tackling modern environmental concerns and reflecting the dynamic nature of research goals. The international network collaboration indicated that a four-country collaboration exist where Indonesia had a strong network with England and Finland. Future Indigenous knowledge and sustainable resource management research should examine contextual factors that affect publication patterns to build on these findings. The causes of the highest publishing years and database discrepancies may be examined. A detailed analysis of research activity changes can help explain this field’s research trend.
On the crossroads of faith: the catholic church and the Serbian Orthodox Church in the Kingdom of the Serbs, Croats and Slovenes/Yugoslavia through the eyes of US ministers and consuls in Belgrade and Zagreb
Authors: Jareb Mario
Published: November 2024

Data on religious life, that is, the activities of various religious communities and organizations/churches, were often mentioned and analyzed on the pages of dispatches and reports compiled by US ministers in Belgrade and consuls in Zagreb. They are available primarily among the documents of the National Archives and Records Administration (NARA), Record Group (RG) 84, Records of Foreign Service Posts, Diplomatic Posts, Yugoslavia, and on two microfilm publications published by NARA. Most attention in dispatches and reports was devoted to the Serbian Orthodox Church as a kind of state church of the Kingdom and to the Catholic Church, which at the same time represented the vast majority of Croats (and Slovenes).
The Late Medieval Zagreb County as the Part of Antemurale Christianitats. The Case Study of Zrin Estate
Authors: Kekez Hrvoje
Published: November 2024

Although Ottoman raids on parts of Medieval Slavonia, which is now Central Croatia, began in the early 15th century, it wasn't until the fall of the Medieval Kingdom of Bosnia into Ottoman hands in 1463 that the raids intensified and the Ottoman raiders continuously plundered areas of medieval Croatia and Slavonia. It was during the mid-15th century that Croatian lands started to be recognized as Antemurale Christianitatis, meaning they were seen as frontier states of Western Christendom, primarily serving as a defensive barrier against non-Christian peoples in the East. During this time, several important strongholds were established in the late medieval Zagreb County, particularly on the Zrin estate, to defend against the Ottomans. Feudal lords of medieval Croatia and Slavonia began organizing elaborate defensive systems on their estates, consisting of strategically positioned smaller and larger strongholds. The Zrin estate was one such example. This paper focuses on the defensive systems of the Zrin estate during the late 15th and first half of the 16th century. It examines the number, typology, and fortification features of the strongholds on the estate, as well as their strategic positions and defensive capabilities.
Historia dworu i zamku Berezowiec Kmitów Stretowiczów w świetle źródeł pisanych z XVI - pierwszej połowy XVII wieku i badań archeologicznych, część 2
Authors: Wawrzeniuk Joanna , Poczobut Natalia , Koledinskij Leonid
Published: November 2024

Na wschód od wsi Berezowiec (w rejonie korelickim, w obwodzie grodzieńskim na Białorusi), nad rzeką Serwecz, znajduje się wzgórze zamkowe wpisane do rejestru zabytków. Badania archeologiczne prowadzone w latach 2013-2015 ujawniły konstrukcję ceglaną z pierwszej połowy XVI wieku oraz zmiany w zabudowie dziedzińca zamkowego za czasów Radziwiłłów w pierwszej połowie XVII wieku. O elitarnej roli miejsca i jego mieszkańców świadczy również wyjątkowy materiał ruchomy: szczególnie srebrne monety, biżuteria, fragmenty odzieży i obuwia, broń, narzędzia i artykuły gospodarstwa domowego, kafle piecowe, naczynia szklane i szkło okienne, a także zabytki do zabaw i gier oraz importowane fragmenty naczyń i plomby ołowiane.
Menstrual Cycle Variations Observed in Obese and Normal-Weight Women
Authors: Desmawati Desmawati , Berliani Hasvia , Utama Bobby Indra
Published: November 2024

Obesity plays a significant role in estrogen production, which can lead to menstrual cycle disorders. This study aimed to determine differences in estrogen levels and menstrual cycles between obese and normal-weight female students at the Faculty of Medicine, Universitas Andalas. This study used the comparative cross-sectional design involving 32 obese respondents and 32 respondents with normal-weight status, selected through a systematic random sampling method. The study was conducted from November 2021 to July 2022. Estrogen levels were measured using the enzyme-linked immune assay (ELISA) method, and the menstrual cycle data were collected via interview. Statistical analysis was performed using an unpaired t-test and a Chi-square test. The results showed no significant difference in estrogen levels between the obese group (188.31±47.56 pg/mL) and the normal-weight group (181.76±51.06 pg/mL) (p > 0.05). However, abnormal menstrual cycles were more common in the obese group (29.7%) compared to the normal group (9.4%), with a p-value of 0.002. In conclusion, there are no differences in estrogen levels between the normal nutrition and obese groups; however, the menstrual cycles of these groups are different.