bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of “Glass Curtain” Systems to Improve the Energy Efficiency and Thermal Comfort of Dwellings in a Warm Semi-Arid Mediterranean Climate
Authors: Pérez-Carramiñana Carlos , Sabatell-Canales Samuel , González-Avilés Ángel Benigno , Galiano-Garrigós Antonio
Published: December 2023

The dry Mediterranean climate (BShs) within a warm semi-arid climate (BSh) is the zone in Europe with the most annual hours of sunlight, and it has a smaller annual temperature variation than most climates. This allows the greenhouse effect caused by windows to be used to heat dwellings in winter. Balcony frameless retractable glazing systems known as “glass curtain” systems offer the highest proportion of glass and maximum openness in the façade, allowing for maximum sunlight and ventilation. This work studies a glazed terrace with a “glass curtain” in a dwelling on the Spanish Mediterranean coastline. The objective is to quantitatively determine the enhancement of the thermal comfort and energy efficiency of a dwelling using “glass curtain” systems. The modification of several design parameters of the glazed terrace is also analysed. The novelty of this study lies in demonstrating that the use and optimised design of “glass curtain” systems allows us to obtain nearly zero-energy buildings (nZEBs) and thermally comfortable dwellings all year round. The research methods include a comparison of the current thermal performance of the dwelling with and without a “glass curtain” system via on-site measurements. The study also evaluates the influence of modifying design parameters using computer simulations. The results show that “glass curtain” systems increase the indoor temperatures inside the dwelling by about 4 °C in winter and reduce the annual indoor thermal oscillation from more than 16 °C to only 10 °C. Consequently, such systems reduce heating energy needs by almost 60%. Glazed terraces using the proposed design parameters show further improvement regarding thermal comfort and practically eliminate heating and cooling needs.
Environmental and Genetic Traffic in the Journey from Sperm to Offspring
Authors: Sengupta Pallav , Dutta Sulagna , Liew Fong Fong , Dhawan Vidhu , Das Biprojit , Mottola Filomena , Slama Petr , Rocco Lucia , Roychoudhury Shubhadeep
Published: December 2023

Recent advancements in the understanding of how sperm develop into offspring have shown complex interactions between environmental influences and genetic factors. The past decade, marked by a research surge, has not only highlighted the profound impact of paternal contributions on fertility and reproductive outcomes but also revolutionized our comprehension by unveiling how parental factors sculpt traits in successive generations through mechanisms that extend beyond traditional inheritance patterns. Studies have shown that offspring are more susceptible to environmental factors, especially during critical phases of growth. While these factors are broadly detrimental to health, their effects are especially acute during these periods. Moving beyond the immutable nature of the genome, the epigenetic profile of cells emerges as a dynamic architecture. This flexibility renders it susceptible to environmental disruptions. The primary objective of this review is to shed light on the diverse processes through which environmental agents affect male reproductive capacity. Additionally, it explores the consequences of paternal environmental interactions, demonstrating how interactions can reverberate in the offspring. It encompasses direct genetic changes as well as a broad spectrum of epigenetic adaptations. By consolidating current empirically supported research, it offers an exhaustive perspective on the interwoven trajectories of the environment, genetics, and epigenetics in the elaborate transition from sperm to offspring.
Genomics for Emerging Pathogen Identification and Monitoring: Prospects and Obstacles
Authors: Vashisht Vishakha , Vashisht Ashutosh , Mondal Ashis K. , Farmaha Jaspreet , Alptekin Ahmet , Singh Harmanpreet , Ahluwalia Pankaj , Srinivas Anaka , Kolhe Ravindra
Published: December 2023

Emerging infectious diseases (EIDs) pose an increasingly significant global burden, driven by urbanization, population explosion, global travel, changes in human behavior, and inadequate public health systems. The recent SARS-CoV-2 pandemic highlights the urgent need for innovative and robust technologies to effectively monitor newly emerging pathogens. Rapid identification, epidemiological surveillance, and transmission mitigation are crucial challenges for ensuring public health safety. Genomics has emerged as a pivotal tool in public health during pandemics, enabling the diagnosis, management, and prediction of infections, as well as the analysis and identification of cross-species interactions and the categorization of infectious agents. Recent advancements in high-throughput DNA sequencing tools have facilitated rapid and precise identification and characterization of emerging pathogens. This review article provides insights into the latest advances in various genomic techniques for pathogen detection and tracking and their applications in global outbreak surveillance. We assess methods that leverage pathogen sequences and explore the role of genomic analysis in understanding the epidemiology of newly emerged infectious diseases. Additionally, we address technical challenges and limitations, ethical and legal considerations, and highlight opportunities for integrating genomics with other surveillance approaches. By delving into the prospects and obstacles of genomics, we can gain valuable insights into its role in mitigating the threats posed by emerging pathogens and improving global preparedness in the face of future outbreaks.
Cerebellum’s Contribution to Attention, Executive Functions and Timing: Psychophysiological Evidence from Event-Related Potentials
Authors: Mannarelli Daniela , Pauletti Caterina , Missori Paolo , Trompetto Carlo , Cotellessa Filippo , Fattapposta Francesco , Currà Antonio
Published: December 2023

Since 1998, when Schmahmann first proposed the concept of the “cognitive affective syndrome” that linked cerebellar damage to cognitive and emotional impairments, a substantial body of literature has emerged. Anatomical, neurophysiological, and functional neuroimaging data suggest that the cerebellum contributes to cognitive functions through specific cerebral–cerebellar connections organized in a series of parallel loops. The aim of this paper is to review the current findings on the involvement of the cerebellum in selective cognitive functions, using a psychophysiological perspective with event-related potentials (ERPs), alone or in combination with non-invasive brain stimulation techniques. ERPs represent a very informative method of monitoring cognitive functioning online and have the potential to serve as valuable biomarkers of brain dysfunction that is undetected by other traditional clinical tools. This review will focus on the data on attention, executive functions, and time processing obtained in healthy subjects and patients with varying clinical conditions, thus confirming the role of ERPs in understanding the role of the cerebellum in cognition and exploring the potential diagnostic and therapeutic implications of ERP-based assessments in patients.
Robot- and Technology-Boosting Neuroplasticity-Dependent Motor-Cognitive Functional Recovery: Looking towards the Future of Neurorehabilitation
Authors: Morone Giovanni , Iosa Marco , Calabrò Rocco Salvatore , Cerasa Antonio , Paolucci Stefano , Antonucci Gabriella , Ciancarelli Irene
Published: December 2023

The sequelae of neurological disorders are the leading causes of disability in all industrialized countries [...]
Image Findings as Predictors of Fall Risk in Patients with Cerebrovascular Disease
Authors: Tomita Tatsuya , Yuminaga Hisanori , Takashima Hideki , Masuda Takashi , Mano Tomoo
Published: December 2023

This study examined computed tomography findings in patients with cerebrovascular disease and determined predictors for falls. Images of the head were divided into 13 regions, and the relationships between computed tomography findings and the presence or absence of falls were investigated. A total of 138 patients with cerebrovascular disease (66% men, aged 73.8 ± 9.6 years) were included. A comparison between the fall and non-fall groups revealed a significant difference in the total functional independence measure scores and imaging findings at admission. Logistic regression analysis showed that the thalamus (p < 0.001), periventricular lucency (p < 0.001), lateral hemisphere room enlargement (p < 0.05), and age (p < 0.05) were related to the presence or absence of falls. For the 42 patients with cerebral hemorrhage, the thalamus (p < 0.01), periventricular lucency (p < 0.05), lateral ventricle vicinity (p < 0.05), and posterior limb of the internal capsule (p < 0.05) were extracted as factors related to the presence or absence of falls. For the 96 patients with cerebral infarction, the thalamus (p < 0.001), periventricular lucency (p < 0.01), and anterior limb of the internal capsule (p < 0.05) were extracted as factors related to the presence or absence of falls. This study found a relationship between the thalamus, lateral ventricle enlargement, periventricular lucency, and falls. Fall prognosis can potentially be predicted from computed tomography findings at admission.
What’s in a Name? Chronic Vestibular Migraine or Persistent Postural Perceptual Dizziness?
Authors: Tarnutzer Alexander A. , Kaski Diego
Published: December 2023

Current consensus diagnostic criteria for vestibular migraine (VM) describes this as an episodic disorder. However, a minority of patients report prolonged (>72 h duration) or even persistent VM symptoms, prompting whether a chronic variant of vestibular migraine (CVM) should be introduced to the current classification and how best to define it. Here we summarize current evidence of such a potential chronic variant of VM and critically review proposed definitions for CVM. Potential approaches to establish a diagnostic framework for CVM include (a) following the distinction between episodic and chronic migraine headaches, namely, frequent and/or prolonged episodes of VM (but not persistent vertigo or dizziness) in the context of chronic migraine headaches or (b) daily dizzy spells over more than 6 months that responded well to prophylactic anti-migraine therapy. A key challenge when defining diagnostic criteria for CVM is how to distinguish it from other chronic vestibular syndromes such as motion sickness, persistent postural-perceptual dizziness (PPPD), and mal de débarquement syndrome. Indeed, more than 50% of patients with PPPD and up to 46% with mal de débarquement syndrome fulfil diagnostic criteria for episodic migraine headaches, suggesting these disorders may all lie along a spectrum. We propose that when VM becomes persistent, it is best classified as PPPD but that VM and PPPD are not mutually exclusive, such that patients with PPPD need not have features of VM, and the triggering event for persistent dizziness may be independent of migraine. However, further research is needed to better characterize the spectrum of clinical phenotypes in patients with chronic dizziness, migraine headaches and anxiety, to define whether a chronic variant of VM sufficiently differs from current persistent dizziness definitions.
Exposure to the Death of Others during the COVID-19 Pandemic: Growing Mistrust in Medical Institutions as a Result of Personal Loss
Authors: Gully Brian J. , Padovano Hayley Treloar , Clark Samantha E. , Muro Gabriel J. , Monnig Mollie A.
Published: December 2023

Background and aims: The prominence of death during the COVID-19 pandemic was heightened by the potential of personally knowing someone who lost their life to the virus. The terror management theory (TMT) suggests that the salient presence of death has a pronounced effect on behavior and may result in the ossification of beliefs and actions aligned with one’s worldview (i.e., the mortality salience hypothesis). In this study, we evaluated how death exposure early in the COVID-19 pandemic could enact the process of firming up held beliefs and attitudes related to health and safety. Specifically, we tested the hypothesis that exposure to a personal loss during the pandemic would strengthen participants’ baseline attitudes and behaviors regarding COVID-19 safety guidelines. Method: Data were analyzed from a prospective, regional survey administered at two time points during the pandemic, June–July 2020 and May 2021, in five United States northeastern states. Baseline and follow-up surveys were administered approximately 12 months apart, with adherence to public guidance and death exposure measured at both timepoints and other safety measures at follow-up only. Findings: Our results indicated that there were significant main effects of death exposure on guideline adherence and support for COVID-related public policy. Contrary to the mortality salience hypothesis, death exposures after baseline were related to higher medical mistrust at follow-up for those high in adherence at baseline, rather than those with low adherence. Conclusion: Our results offer some conflicting evidence to the mortality salience hypothesis. Rather than entrench people in their worldviews, death in the context of the COVID-19 pandemic appeared to sway people away from their initial stances. This finding has important implications for TMT literature and for the COVID-19 pandemic response.
Left-Behind Experiences and Cyberbullying Behavior in Chinese College Students: The Mediation of Sense of Security and the Moderation of Gender
Authors: Wang Haiying , Wu Shuang , Wang Weichen , Xiao Yuming
Published: December 2023

Left-behind children seem to be more sensitive in interpersonal communication, find it more difficult to establish a stable, safe relationship with surrounding people, and have fewer positive coping styles when encountering problems, thus the aim of the present study was to explore the association between left-behind experiences and cyberbullying behavior among Chinese college students through the mediation of sense of security and the moderation of gender. A questionnaire survey comprised 553 college students with left-behind experiences and 526 college students without such experiences. The results showed that, firstly, cyberbullying behavior was significantly higher in college students with left-behind experiences than those without such experiences; secondly, left-behind experiences and cyberbullying behavior in college students was partially mediated by a sense of security; and finally, that gender moderated the mediation of the sense of security between left-behind experiences and cyberbullying behavior. This study suggests the family environment is important for individual growth and illustrates how the influence of childhood left-behind experience persists in individuals.
Depression and Anxiety among Undergraduate Health Science Students: A Scoping Review of the Literature
Authors: Agyapong-Opoku Gerald , Agyapong Belinda , Obuobi-Donkor Gloria , Eboreime Ejemai
Published: December 2023

Background: Health science students in post-secondary institutions experience high levels of depression and anxiety due to increased stress levels, workload, low socioeconomic status, and history of family mental illness, among other factors. Given the significant negative impact that depression and anxiety can have on undergraduate health science students, it is essential to understand the prevalence and correlation of these conditions in this population. In light of this, this scoping review aims to identify, document, and analyze the literature on the prevalence and determinants of anxiety and depression among undergraduate health sciences students and identify gaps in knowledge for future research. Methods: This scoping review was planned and executed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for the Scoping Reviews statement. A comprehensive and systematic search was carried out for five databases, namely MEDLINE, Scopus, EMBASE, CINAHL, and PubMed. Results: From the literature identified by our search strategy, the lowest prevalence for anxiety was 5.8%, and the highest was 82.6%, with a median of 44.25%. The prevalence of depression ranged from a high of 88.8% to a low of 2.1%, with a median value of 34.8%. Our analysis revealed that correlates of anxiety and depression among health science students include sociodemographic factors such as age, sex, gender, relationships, ethnicity, and family history, personal health conditions, and academic and socioeconomic issues. Conclusions: With the high incidence of anxiety and depression among health science students, there is an increasing need to find practical remedies to support these students. It is also essential for policymakers and university authorities to implement interventions such as supportive text messages and other strategies geared toward providing support and improving the psychological well-being of health science students.
Natural Killer T Cell Diversity and Immunotherapy
Authors: Tognarelli Eduardo I. , Gutiérrez-Vera Cristián , Palacios Pablo A. , Pasten-Ferrada Ignacio A. , Aguirre-Muñoz Fernanda , Cornejo Daniel A. , González Pablo A. , Carreño Leandro J.
Published: December 2023

Invariant natural killer T cells (iNKTs), a type of unconventional T cells, share features with NK cells and have an invariant T cell receptor (TCR), which recognizes lipid antigens loaded on CD1d molecules, a major histocompatibility complex class I (MHC-I)-like protein. This interaction produces the secretion of a wide array of cytokines by these cells, including interferon gamma (IFN-γ) and interleukin 4 (IL-4), allowing iNKTs to link innate with adaptive responses. Interestingly, molecules that bind CD1d have been identified that enable the modulation of these cells, highlighting their potential pro-inflammatory and immunosuppressive capacities, as required in different clinical settings. In this review, we summarize key features of iNKTs and current understandings of modulatory α-galactosylceramide (α-GalCer) variants, a model iNKT cell activator that can shift the outcome of adaptive immune responses. Furthermore, we discuss advances in the development of strategies that modulate these cells to target pathologies that are considerable healthcare burdens. Finally, we recapitulate findings supporting a role for iNKTs in infectious diseases and tumor immunotherapy.
Allogeneic Stem Cell Transplantation in Multiple Myeloma: Risk Factors and Outcomes in the Era of New Therapeutic Options—A Single-Center Experience
Authors: Strassl Irene , Nikoloudis Alexander , Machherndl-Spandl Sigrid , Buxhofer-Ausch Veronika , Binder Michaela , Wipplinger Dagmar , Stiefel Olga , Kaynak Emine , Milanov Robert , Aichinger Christoph , Nocker Stefanie , Bauer Thomas , Kreissl Stefanie , Girschikofsky Michael , Petzer Andreas , Weltermann Ansgar , Clausen Johannes
Published: December 2023

Background: Despite major treatment advances, multiple myeloma remains incurable. The outcome of patients who are refractory to immunomodulatory agents, proteasome inhibitors, and anti-CD38 monoclonal antibodies is poor, and improved treatment strategies for this difficult-to-treat patient population are an unmet medical need. Methods: This retrospective, unicentric analysis included 38 patients with relapsed/refractory multiple myeloma or plasma cell leukemia who underwent allogeneic stem cell transplantation (allo-HSCT) between 2013 and 2022. Survival outcomes, relapse incidence, and non-relapse mortality were calculated according to remission status, date of allo-HSCT, cytogenetic risk status, timing, and number of previous autologous HSCTs. Results: The median PFS was 13.6 months (95% CI, 7.7–30.4) and the median OS was 51.4 months (95% CI, 23.5–NA) in the overall cohort. The cumulative incidence of relapse at 3 years was 57%, and non-relapse mortality was 16%. The median PFS and OS were significantly longer in patients with very good partial remission (VGPR) or better compared to patients with less than VGPR at the time of allo-HSCT (mPFS 29.7 months (95% CI, 13.7–NA) vs. 6.5 months (95% CI, 2.6–17.0); p = 0.009 and mOS not reached vs. 18.6 months (95% CI, 7.0–NA); p = 0.006). Conclusion: For selected patients, allo-HSCT may result in favorable overall survival, in part by providing an appropriate hemato-immunological basis for subsequent therapies.
Validation of Claims Data for Absorbing Pads as a Measure for Urinary Incontinence after Radical Prostatectomy, a National Cross-Sectional Analysis
Authors: Baas Diederik J. H. , Reitsma Jan , Gerwen Lieke van , Vleghaar Jaron , Gehlen Jolanda M. L. G. , Ziedses des Plantes Cathelijne M. P. , van Basten Jean Paul A. , van den Bergh Roderick C. N. , Bruins H. Max , Collette Eelco R. P. , Hoekstra Robert J. , Knipscheer Ben C. , van Leeuwen Pim J. , Luijendijk-de Bruin Daphne , van Roermund Joep G. H. , Sedelaar J. P. Michiel , Speel Tommy G. W. , Stomps Saskia P. , Wijburg Carl J. , Wijn Rob P. W. F. , de Jong Igle Jan , Somford Diederik M.
Published: December 2023

The use of healthcare insurance claims data for urinary incontinence (UI) pads has the potential to serve as an objective measure for assessing post-radical prostatectomy UI rates, but its validity for this purpose has not been established. The aim of this study is to correlate claims data with Patient Reported Outcome Measures (PROMs) for UI pad use. Patients who underwent RP in the Netherlands between September 2019 and February 2020 were included. Incontinence was defined as the daily use of ≥1 pad(s). Claims data for UI pads at 12–15 months after RP were extracted from a nationwide healthcare insurance database in the Netherlands. Participating hospitals provided PROMS data. In total, 1624 patients underwent RP. Corresponding data of 845 patients was provided by nine participating hospitals, of which 416 patients were matched with complete PROMs data. Claims data and PROMs showed 31% and 45% post-RP UI (≥1 pads). UI according to claims data compared with PROMs had a sensitivity of 62%, specificity of 96%, PPV of 92%, NPV of 75% and accuracy of 81%. The agreement between both methods was moderate (κ = 0.60). Claims data for pads moderately align with PROMs in assessing post-prostatectomy urinary incontinence and could be considered as a conservative quality indicator.
Biodiesel from Waste Cooking Oil: Highly Efficient Homogeneous Iron(III) Molecular Catalysts
Authors: Langellotti Vincenzo , Melchiorre Massimo , Cucciolito Maria Elena , Esposito Roberto , Grieco Domenico , Pinto Gabriella , Ruffo Francesco
Published: December 2023

This article presents an efficient iron(III) molecular catalyst for the production of biodiesel from waste vegetable oils. The approach involved an initial screening of eight salophen complexes with various substituents on the arene rings, leading to the selection of the simplest unsubstituted species as the most active catalyst. Under optimized conditions, this catalyst demonstrated the capability to achieve complete conversion of the oil at a low catalyst loading (0.10% mol/mol) and convenient conditions (160 °C, 20/1 MeOH/oil ratio).
Single-Cell Radiation Response Scoring with the Deep Learning Algorithm CeCILE 2.0
Authors: Rudigkeit Sarah , Reindl Judith
Published: December 2023

External stressors, such as ionizing radiation, have massive effects on life, survival, and the ability of mammalian cells to divide. Different types of radiation have different effects. In order to understand these in detail and the underlying mechanisms, it is essential to study the radiation response of each cell. This allows abnormalities to be characterized and laws to be derived. Tracking individual cells over several generations of division generates large amounts of data that can no longer be meaningfully analyzed by hand. In this study, we present a deep-learning-based algorithm, CeCILE (Cell classification and in vitro lifecycle evaluation) 2.0, that can localize, classify, and track cells in live cell phase-contrast videos. This allows conclusions to be drawn about the viability of the cells, the cell cycle, cell survival, and the influence of X-ray radiation on these. Furthermore, radiation-specific abnormalities during division could be characterized. In summary, CeCILE 2.0 is a powerful tool to characterize and quantify the cellular response to external stressors such as radiation and to put individual responses into a larger context. To the authors knowledge, this is the first algorithm with a fully integrated workflow that is able to do comprehensive single-cell and cell composite analysis, allowing them to draw conclusions on cellular radiation response.
Piezo1 Is Required for Myoblast Migration and Involves Polarized Clustering in Association with Cholesterol and GM1 Ganglioside
Authors: Vanderroost Juliette , Parpaite Thibaud , Avalosse Noémie , Henriet Patrick , Pierreux Christophe E. , Lorent Joseph H. , Gailly Philippe , Tyteca Donatienne
Published: December 2023

A specific plasma membrane distribution of the mechanosensitive ion channel Piezo1 is required for cell migration, but the mechanism remains elusive. Here, we addressed this question using WT and Piezo1-silenced C2C12 mouse myoblasts and WT and Piezo1-KO human kidney HEK293T cells. We showed that cell migration in a cell-free area and through a porous membrane decreased upon Piezo1 silencing or deletion, but increased upon Piezo1 activation by Yoda1, whereas migration towards a chemoattractant gradient was reduced by Yoda1. Piezo1 organized into clusters, which were preferentially enriched at the front. This polarization was stimulated by Yoda1, accompanied by Ca2+ polarization, and abrogated by partial cholesterol depletion. Piezo1 clusters partially colocalized with cholesterol- and GM1 ganglioside-enriched domains, the proportion of which was increased by Yoda1. Mechanistically, Piezo1 activation induced a differential mobile fraction of GM1 associated with domains and the bulk membrane. Conversely, cholesterol depletion abrogated the differential mobile fraction of Piezo1 associated with clusters and the bulk membrane. In conclusion, we revealed, for the first time, the differential implication of Piezo1 depending on the migration mode and the interplay between GM1/cholesterol-enriched domains at the front during migration in a cell-free area. These domains could provide the optimal biophysical properties for Piezo1 activity and/or spatial dissociation from the PMCA calcium efflux pump.
Therapeutic Consequences of Targeting the IGF-1/PI3K/AKT/FOXO3 Axis in Sarcopenia: A Narrative Review
Authors: Gellhaus Benjamin , Böker Kai O. , Schilling Arndt F. , Saul Dominik
Published: December 2023

The high prevalence of sarcopenia in an aging population has an underestimated impact on quality of life by increasing the risk of falls and subsequent hospitalization. Unfortunately, the application of the major established key therapeutic—physical activity—is challenging in the immobile and injured sarcopenic patient. Consequently, novel therapeutic directions are needed. The transcription factor Forkhead-Box-Protein O3 (FOXO3) may be an option, as it and its targets have been observed to be more highly expressed in sarcopenic muscle. In such catabolic situations, Foxo3 induces the expression of two muscle specific ubiquitin ligases (Atrogin-1 and Murf-1) via the PI3K/AKT pathway. In this review, we particularly evaluate the potential of Foxo3-targeted gene therapy. Foxo3 knockdown has been shown to lead to increased muscle cross sectional area, through both the AKT-dependent and -independent pathways and the reduced impact on the two major downstream targets Atrogin-1 and Murf-1. Moreover, a Foxo3 reduction suppresses apoptosis, activates satellite cells, and initiates their differentiation into muscle cells. While this indicates a critical role in muscle regeneration, this mechanism might exhaust the stem cell pool, limiting its clinical applicability. As systemic Foxo3 knockdown has also been associated with risks of inflammation and cancer progression, a muscle-specific approach would be necessary. In this review, we summarize the current knowledge on Foxo3 and conceptualize a specific and targeted therapy that may circumvent the drawbacks of systemic Foxo3 knockdown. This approach presumably would limit the side effects and enable an activity-independent positive impact on skeletal muscle.
Human Probiotic Lactobacillus paracasei-Derived Extracellular Vesicles Improve Tumor Necrosis Factor-α-Induced Inflammatory Phenotypes in Human Skin
Authors: Lee Kwang-Soo , Kim Yunsik , Lee Jin Hee , Shon Suji , Kim Aram , Pham An Vuong Quynh , Kim Chungho , Kim Dong Hyun , Kim Yoon-Keun , Cho Eun-Gyung
Published: December 2023

Lactic acid bacteria (LAB), a probiotic, provide various health benefits. We recently isolated a new Lactobacillus paracasei strain with strong anti-inflammatory effects under lipopolysaccharide-induced conditions and proposed a new mode of action—augmenting the endoplasmic reticulum stress pathway for anti-inflammatory functions in host cells. The beneficial effects of the L. paracasei strains on the skin have been described; however, the effects of L. paracasei-derived extracellular vesicles (LpEVs) on the skin are poorly understood. Herein, we investigated whether LpEVs can improve inflammation-mediated skin phenotypes by determining their effects on primary human skin cells and a three-dimensional (3D) full-thickness human skin equivalent under tumor necrosis factor (TNF)-α-challenged inflammatory conditions. LpEVs were efficiently taken up by the human skin cells and were much less cytotoxic to host cells than bacterial lysates. Furthermore, low LpEV concentrations efficiently restored TNF-α-induced cellular phenotypes, resulting in increased cell proliferation and collagen synthesis, but decreased inflammatory factor levels (matrix metalloproteinase 1, interleukin 6, and interleukin 8) in the human dermal fibroblasts, which was comparable to that of retinoic acid, a representative antiaging compound. The beneficial effects of LpEVs were validated in a 3D full-thickness human skin equivalent model. LpEV treatment remarkably restored the TNF-α-induced epidermal malformation, abnormal proliferation of keratinocytes in the basal layer, and reduction in dermal collagen synthesis. Additionally, LpEVs penetrated and reached the deepest dermal layer within 24 h when overlaid on top of a 3D full-thickness human skin equivalent. Furthermore, they possessed superior antioxidant capacity compared with the human cell-derived EVs. Taken together, the anti-inflammatory probiotic LpEVs can be attractive antiaging and antioxidant substances for improving inflammation-induced skin phenotypes and disorders.
Planetary Health Initiatives in Rural Education at a Riverside School in Southern Amazonas, Brazil
Authors: de Melo Paula Regina Humbelino , Alves Péricles Vale , de Camargo Tatiana Souza
Published: December 2023

Planetary Health is an expanding scientific field around the world, and actions in different areas are essential to minimize the environmental damage that compromises the future of humanity. This project report aims to describe the development of Planetary Health actions in a rural school in the Brazilian Amazon, to understand and raise awareness of themes related to Planetary Health. To implement the educational activities, a booklet entitled “Planetary Health: Guide for Rural Education” was created. Subsequently, didactic sequences were applied to 37 ninth-grade students in the first semester of 2023. The activities were diversified, including: (1) investigative activities (pre-tests, interviews with family members, ecological footprint adapted to the Amazonian riverside context), (2) interpretative activities (image reading, identification and problem-solving for Planetary Health stories in the Amazon, educational cartoons, and graphs of the sectors with the highest pollution in Brazil and diseases associated with climate change), (3) audiovisual activities (educational videos), (4) playful activities (educational games), (5) practical and field activities (forest tracking, planting seedlings, sanitation trail, construction of a school garden, preparation of a healthy school snack, greenhouse effect simulation, and basic analysis of lake water with a probe). The results of the educational actions allowed students to undergo new experiences on Planetary Health themes, as well as understand the centrality of the Amazon for the planet and how the environmental impacts in this biome are compromising the future of humanity. The experiences during the educational actions showed that young riverside residents are concerned about the future of the Amazon, especially given the environmental destruction that is frequently evident, such as deforestation, fires, illegal mining, and land grabbing. Inserting these themes into riverside education makes it possible to look at the Amazon in a resilient, responsible way and to discuss scientific and local knowledge so that students can develop initiatives to face environmental challenges in their community. We conclude that Planetary Health education needs to be an effective part of the school curriculum, prioritizing reviewing the documents that guide education to prioritize transdisciplinary actions with children and young people, as they are the voices of the future and future leaders in emerging causes. Educational actions in Planetary Health in the Amazon region are an example that can inspire actions in other places with similar characteristics.
Regional Wealth Data Acquisition and Modeling: Innovations Needed for Advancement in Sustainable Wealth in Energy-Rich Regions
Authors: Hubbart Jason A. , Ghadimi Hodjat
Published: December 2023

National-level studies present the development techniques and challenges of sustaining energy-rich economies, particularly those in the developing world. However, examples of the application and interpolation of these broad-scale analyses to the regional level are scarce. Conversely, methods used at national levels are often infeasible when using higher-resolution regional or local data. Ultimately, progress in developing, managing, and advancing regional wealth databases and models is significantly missing from the literature. Herein, proposed pathways and general development frameworks are presented based on the presumptive constancy of total capital stock. Processes are outlined for acquiring information (data) and developing models to serve as a basis for qualitative and quantitative analyses of sustainable development policymaking decisions. We present a discussion around the sustainable wealth of energy-rich regions, and we suggest potential workflow methods for developing regional wealth knowledge bases and regional wealth models (RWMs). Structural scaffolding opportunities are presented for the validation of RWMs using pilot studies, followed by the process of disseminating modeling outcomes. Finally, we offer recommendations and needed innovations to advance the development of RWMs. The objectives of this article are not to provide a comprehensive literature review or consider all potential perspectives but rather to identify tools and necessary enhancements to established methods for assessing and modeling regional wealth and provide an inroad for readers wishing to learn more. The increased awareness generated through this article will mobilize assistance and generate new information that will strengthen this emergent area of research to intensify regional wealth sustainability for future generations.
Pediatric Pain Management: The Time for Action Is Now
Authors: Vittori Alessandro
Published: December 2023

Pediatric anesthesia is a field of research and assistance in which more specialization needs are emerging [...]
Exosomal Cargo in Ovarian Cancer Dissemination
Authors: Dzhugashvili Ekaterina , Tamkovich Svetlana
Published: December 2023

Ovarian cancer (OC) has the highest mortality rate among all gynecologic cancers and is characterized by early peritoneal spread. The growth and development of OC are associated with the formation of ascitic fluid, creating a unique tumor microenvironment. Understanding the mechanisms of tumor progression is crucial in identifying new diagnostic biomarkers and developing novel therapeutic strategies. Exosomes, lipid bilayer vesicles measuring 30–150 nm in size, are known to establish a crucial link between malignant cells and their microenvironment. Additionally, the confirmed involvement of exosomes in carcinogenesis enables them to mediate the invasion, migration, metastasis, and angiogenesis of tumor cells. Functionally active non-coding RNAs (such as microRNAs, long non-coding RNAs, circRNAs), proteins, and lipid rafts transported within exosomes can activate numerous signaling pathways and modify gene expression. This review aims to expand our understanding of the role of exosomes and their contents in OC carcinogenesis processes such as epithelial-mesenchymal transition (EMT), angiogenesis, vasculogenic mimicry, tumor cell proliferation, and peritoneal spread. It also discusses the potential for utilizing exosomal cargo to develop novel “liquid biopsy” biomarkers for early OC diagnosis.
Surface Photovoltage Method for Photovoltaic Quality Control of GaAs-Based Solar Cells
Authors: Donchev Vesselin , Milanova Malina
Published: December 2023

In this paper, we demonstrate the potential of the contactless surface photovoltage (SPV) method for fast and reliable control of GaAs-based solar cells directly on epitaxial heterostructures before metallization and photolithography processes. The magnitude of the SPV corresponds to the generated photovoltage in the photoactive region, which is related to the open circuit voltage of the cell. The focus of this investigation is the potential of dilute nitride compounds grown by low-temperature liquid-phase epitaxy (LPE) for application as intermediate cells in multijunction solar cells. First, SPV spectroscopy is used to determine the photosensitivity spectral range and bandgap of the grown dilute nitride compound layers. Further, the photovoltaic quality of the grown solar cell heterostructures is evaluated by comparing the magnitude of their SPV signals with that of a reference GaAs solar cell. A drastic reduction in the measured SPV is observed for nitrogen-containing solar cell structures, which correlates with the lowering of solar cell open-circuit voltage values measured under standard test conditions. Finally, solar cell structures based on nitrogen-free GaAsSb compounds with the same long-wavelength photosensitivity limit as GaAsSbN are grown by LPE. They show one order of magnitude higher SPV signal and, therefore, have a great potential for solar cell application.
Titanium Carbide Coating for Hafnium Hydride Neutron Control Rods: In Situ X-ray Diffraction Study
Authors: Sidelev Dmitrii V. , Pirozhkov Alexey V. , Mishchenko Denis D. , Syrtanov Maxim S.
Published: December 2023

This article considers the possibility of using a magnetron-deposited coating for the protection of hafnium hydrides at high temperatures as a material for neutron control rods. We describe the role of TiC coating in the high-temperature behavior of hafnium hydrides in a vacuum. A 1 µm thick TiC coating was deposited through magnetron sputtering on the outer surface of disk HfHx samples, and then in situ X-ray diffraction (XRD) measurements of both the uncoated and TiC-coated HfHx samples were performed using synchrotron radiation (at a wavelength of 1.64 Å) during linear heating, the isothermal stage (700 and 900 °C), and cooling to room temperature. Quadrupole mass spectrometry was used to identify the hydrogen release from the uncoated and TiC-coated hafnium hydride samples during their heating. We found the decomposition of the HfH1.7 phase to HfH1.5 and Hf and following hafnium oxidation after the significant decrease in hydrogen flow in the uncoated HfHx samples. The TiC coating can be used as a protective layer for HfHx under certain conditions (up to 700 °C); however, the fast hydrogen release can occur in the case of a coating failure. This study shows the temperature range for the possible application of TiC coatings for the protection of hafnium hydride from hydrogen release.
A Systematic Review of Using Machine Learning and Natural Language Processing in Smart Policing
Authors: Sarzaeim Paria , Mahmoud Qusay H. , Azim Akramul , Bauer Gary , Bowles Ian
Published: December 2023

Smart policing refers to the use of advanced technologies such as artificial intelligence to enhance policing activities in terms of crime prevention or crime reduction. Artificial intelligence tools, including machine learning and natural language processing, have widespread applications across various fields, such as healthcare, business, and law enforcement. By means of these technologies, smart policing enables organizations to efficiently process and analyze large volumes of data. Some examples of smart policing applications are fingerprint detection, DNA matching, CCTV surveillance, and crime prediction. While artificial intelligence offers the potential to reduce human errors and biases, it is still essential to acknowledge that the algorithms reflect the data on which they are trained, which are inherently collected by human inputs. Considering the critical role of the police in ensuring public safety, the adoption of these algorithms demands careful and thoughtful implementation. This paper presents a systematic literature review focused on exploring the machine learning techniques employed by law enforcement agencies. It aims to shed light on the benefits and limitations of utilizing these techniques in smart policing and provide insights into the effectiveness and challenges associated with the integration of machine learning in law enforcement practices.
Influence of Si Addition on the Chemical and Tribological Performance of TiAlCrN Coating Deposited by Co-Sputtering
Authors: Ardila L. C. , Dueñas R. , Orozco G. , Olaya J. J. , Ordoñez A. F. , Moreno C. M. , Pineda Y.
Published: December 2023

In this work, nanostructured TiAlCrN coatings were deposited on a WC-Co substrate using a co-sputtering process varying the silicon composition on the coatings. The influence of silicon content on the mechanical, chemical, and tribological performance of the coatings was studied. The hardness increases from 11 to 16 GPa with the Si content; also, Young’s modulus increases from 260 to 295 GPa. The H/E ratio, which is a measure of materials’ ability to take the strain before deformation, is also increased with the increase in Si content, suggesting increased toughness. XPS analysis reveals that the coatings present titanium, aluminum, chromium, and silicon nitrides. The tribological behavior of the coatings was conducted through ball-on-disc tests, in which the results show that the coefficients of friction range from 0.15 to 0.55, with the lowest for the samples with the highest Si content. This behavior is benefited by the formation of oxynitride species, identified by XPS, which acts as lubricating layers and diffusion barriers. TiAlCrSixN coating presents a potential application for severe wear owing to its tribological performance.
Not a Silent Invasion: The Reaction of European Naturalists to the Spread of Zebra Mussel (Dreissena polymorpha) in the 19th—Early 20th Century
Authors: Vinarski Maxim V.
Published: December 2023

The case of naturalization of the zebra mussel, Dreissena polymorpha (Pallas, 1771), in countries lying beyond its native Ponto–Caspian range is remarkable as one of the first instances when the scientific community as early as the mid-19th century was fully aware of the non-indigenous status of a particular species as well as of the need for the study and monitoring of this process. Based on a study of contemporary sources, I reconstruct the early response of European naturalists (including those who today would be called “citizen scientist”) to the invasion of Dreissena and describe their attitudes to the problem, including the divergence in opinion about the origin and the means of dispersal of this bivalve species. An analysis of papers published in English, French, German, and Russian between 1774 and 1920 showed that the invasion of D. polymorpha was by no means “silent”; quite the opposite, it provoked an immediate reaction from naturalists. The scientific agenda for the study of the new invader was proposed in England as early as 1838.
Techno-Economic Feasibility Study of a 1.5 MW Grid-Connected Solar Power Plant in Bangladesh
Authors: Ali Md. Feroz , Sarker Nitai Kumar , Hossain Md. Alamgir , Alam Md. Shafiul , Sanvi Ashraf Hossain , Syam Sifat Syed Ibn
Published: December 2023

This study addresses the pressing energy constraints in nations like Bangladesh by proposing the implementation of photovoltaic (PV) microgrids. Given concerns about environmental degradation, limited fossil fuel reserves, and volatile product costs, renewable energy sources are gaining momentum globally. Our research focuses on a grid-connected solar PV system model at Char Jazira, Lalpur, Natore, Rajshahi, Bangladesh. Through PVsyst 7.1 simulation software, we assess the performance ratio (PR) and system losses, revealing an annual solar energy potential of 3375 MWh at standard test condition (STC) efficiency. After considering losses, the system generates 2815.2 MWh annually, with 2774 MWh exported to the grid. We analyze an average PR of 78.63% and calculate a levelized cost of energy (LCOE) of 2.82 BDT/kWh [1 USD = 110 BDT]. The financial assessment indicates a cost-effective LCOE for the grid-connected PV system, with an annual gross income of 27,744 kBDT from selling energy to the grid and operating costs of 64,060.60 BDT/year. Remarkably, this initiative can prevent 37,647.82 tCO2 emissions over the project’s 25-year lifespan.
Male Breast: A Review of the Literature and Current State of the Art of Diagnostic Imaging Work-Up
Authors: D’Angelo Anna , Portaluri Antonio , Caprini Flavia , Sofia Carmelo , Ferrara Francesca , Condorelli Elvira , Iaccarino Ludovica , Catanzariti Francesca , Mancino Matteo , Trombadori Charlotte M. L. , Belli Paolo , Marino Maria Adele
Published: December 2023

Pathological conditions affecting the male breast (MB) share some similarities with those found in women, while others are specific to men. The first part of this review provides an overview of MB disorders, exploring the most common types of MB diseases. The second part then emphasizes the state-of-the-art approaches proposed in the literature for screening and follow-up with MB cancer patients, which highlights the importance of tailored strategies for diagnosis, follow-up, and identifying high-risk populations. Considering the increasing attention in recent years on the topic, transgender individuals are also included in this review. Together with the MB, it is an understudied category thus far. This review aims to raise awareness among radiologists that MBs should be approached differently from female breasts, contributing to the advancement of medical knowledge, improving patient outcomes, and promoting early detection of MB disorders. The review also provides an update on breast cancer and screening in the transgender population.