bluuebunny/crossref_metadata_2025 huggingface dataset:
Nucleus incertus provides eye velocity and position signals to the vestibulo-ocular cerebellum: a new perspective of the brainstem–cerebellum–hippocampus network
Authors: Cheron Guy , Ris Laurence , Cebolla Ana Maria
Published: May 2023

The network formed by the brainstem, cerebellum, and hippocampus occupies a central position to achieve navigation. Multiple physiological functions are implicated in this complex behavior. Among these, control of the eye–head and body movements is crucial. The gaze-holding system realized by the brainstem oculomotor neural integrator (ONI) situated in the nucleus prepositus hypoglossi and fine-tuned by the contribution of different regions of the cerebellum assumes the stability of the image on the fovea. This function helps in the recognition of environmental targets and defining appropriate navigational pathways further elaborated by the entorhinal cortex and hippocampus. In this context, an enigmatic brainstem area situated in front of the ONI, the nucleus incertus (NIC), is implicated in the dynamics of brainstem–hippocampus theta oscillation and contains a group of neurons projecting to the cerebellum. These neurons are characterized by burst tonic behavior similar to the burst tonic neurons in the ONI that convey eye velocity-position signals to the cerebellar flocculus. Faced with these forgotten cerebellar projections of the NIC, the present perspective discusses the possibility that, in addition to the already described pathways linking the cerebellum and the hippocampus via the medial septum, these NIC signals related to the vestibulo-ocular reflex and gaze holding could participate in the hippocampal control of navigation.
Prognosis of resectable colorectal liver metastases after surgery associated with pathological features of primary tumor
Authors: Chen Dawei , Li Qingshan , Yu Haibo
Published: May 2023

Background

Surgery is an important means for patients with colorectal liver metastases (CRLM) to improve their long-term survival, and accurate screening of high-risk factors is crucial to guiding postoperative monitoring and treatment. With this in mind, the aim of this study was to investigate the expression levels and prognostic roles of Mismatch Repair (MMR), Ki67, and Lymphovascular invasion(LVI) in the tumor tissues of colorectal of CRLM.

Methods

85 Patients with CRLM who received surgical treatment for liver metastases after colorectal cancer resection from June, 2017 and Jan, 2020 were included in this study. Independent risk factors affecting the survival of patients with CRLM were investigated using a Cox regression model and the Kaplan-Meier method, and a nomogram for predicting the OS of patients with CRLM was established according to a Cox multivariate regression model. Calibration plots and Kaplan-Meier curves were used to assess the performance of the nomogram.

Results

The median survival time was 39 months (95% CI: 32.05-45.950), and MMR, Ki67 and LVI were significantly correlated with prognosis. Univariate analysis indicated that larger metastasis size (p=0.028), more than one liver metastases (p=0.001),higher serum CA199 (p<0.001), N1-2 stage (p<0.001), the presence of LVI (p=0.001), higher Ki67 (p<0.001), and pMMR predicted worse OS. In addition, synchronous liver metastasis (p = 0.008), larger metastasis size (p=0.02), more than one liver metastases (p<0.001),higher serum CA199 (p<0.001), the presence of LVI (p=0.001), nerve invasion (p=0.042) higher Ki67 (p=0.014), and pMMR (p=0.038) were each associated with worse DFS. Multivariate analysis indicated that higher serum CA199 (HR = 2.275, 95%CI: 1.302-3.975 p=0.004), N1-2 stage(HR = 2.232, 95%CI: 1.239-4.020 p=0.008), the presence of LVI (HR = 1.793, 95%CI: 1.030-3.121 p=0.039), higher Ki67 (HR = 2.700, 95%CI: 1.388-5.253\ p=0.003), and pMMR (HR = 2.213, 95%CI: 1.181-4.993 p=0.046) all predicted worse OS. Finally, synchronous liver metastasis (HR = 2.059, 95%CI: 1.087-3.901 p=0.027), more than one liver metastases ((HR =2.025, 95%CI: 1.120-3.662 p=0.020),higher serum CA199 (HR =2.914, 95%CI: 1.497-5.674 p=0.002), present LVI (HR = 2.055, 95%CI: 1.183-4.299 p=0.001), higher Ki67 (HR = 3.190, 95%CI: 1.648-6.175 p=0.001) and pMMR(HR = 1.676, 95%CI: 1.772-3.637 p=0.047) predicted worse DFS, and the nomogram achieved an effective level of predictive ability.

Conclusion

This study showed that MMR, Ki67, and Lymphovascular invasion were independent risk factors for the postoperative survival of CRLM patients, and a nomogram model was constructed to predict the OS of these patients after liver metastasis surgery. These results can help surgeons and patients to develop more accurate and individualized follow-up strategies and treatment plans after this surgery.
Research progress of targeted therapy combined with immunotherapy for hepatocellular carcinoma
Authors: Xie Shuqi , Wang Mengchao , Zeng Chuanxiu , Ou Yan , Zhao Lu , Wang Dong , Chen Liwei , Kong Fanming , Yi Dan
Published: May 2023

Hepatocellular carcinoma is a common gastrointestinal malignancy with a high mortality rate and limited treatment options. Molecularly targeted drugs combined with immune checkpoint inhibitors have shown unique advantages over single-agent applications, significantly prolonging patient survival. This paper reviews the research progress of molecular-targeted drugs combined with immune checkpoint inhibitors in the treatment of hepatocellular carcinoma and discusses the effectiveness and safety of the combination of the two drugs to provide a reference for the further application of molecular-targeted drugs combined with immune checkpoint inhibitors in clinical practice.
Genome-wide identification of the WRKY gene family in Camellia oleifera and expression analysis under phosphorus deficiency
Authors: Su Wenjuan , Zhou Zengliang , Zeng Jin , Cao Ruilan , Zhang Yunyu , Hu Dongnan , Liu Juan
Published: May 2023

Camellia oleifera Abel. is an economically important woody edible-oil species that is mainly cultivated in hilly areas of South China. The phosphorus (P) deficiency in the acidic soils poses severe challenges for the growth and productivity of C. oleifera. WRKY transcription factors (TFs) have been proven to play important roles in biological processes and plant responses to various biotic/abiotic stresses, including P deficiency tolerance. In this study, 89 WRKY proteins with conserved domain were identified from the C. oleifera diploid genome and divided into three groups, with group II further classified into five subgroups based on the phylogenetic relationships. WRKY variants and mutations were detected in the gene structure and conserved motifs of CoWRKYs. Segmental duplication events were considered as the primary driver in the expanding process of WRKY gene family in C. oleifera. Based on transcriptomic analysis of two C. oleifera varieties characterized with different P deficiency tolerances, 32 CoWRKY genes exhibited divergent expression patterns in response to P deficiency stress. qRT-PCR analysis demonstrated that CoWRKY11, -14, -20, -29 and -56 had higher positive impact on P-efficient CL40 variety compared with P-inefficient CL3 variety. Similar expression trends of these CoWRKY genes were further observed under P deficiency with longer treatment period of 120d. The result indicated the expression sensitivity of CoWRKYs on the P-efficient variety and the C. oleifera cultivar specificity on the P deficiency tolerance. Tissue expression difference showed CoWRKYs may play a crucial role in the transportation and recycling P in leaves by affecting diverse metabolic pathways. The available evidences in the study conclusively shed light on the evolution of the CoWRKY genes in C. oleifera genome and provided a valuable resource for further investigation of functional characterization of WRKY genes involved to enhance the P deficiency tolerance in C. oleifera.
Conversational pragmatics: memory reporting strategies in different social contexts
Authors: Martín-Luengo Beatriz , Luna Karlos , Shtyrov Yury
Published: May 2023

Previous studies in conversational pragmatics have showed that the information people share with others heavily depends on the confidence they have in the correctness of a candidate answer. At the same time, different social contexts prompt different incentive structures, which set a higher or lower confidence criterion to determine which potential answer to report. In this study, we investigated how the different incentive structures of several types of social contexts and how different levels of knowledge affect the amount of information we are willing to share. Participants answered easy, intermediate, and difficult general-knowledge questions and decided whether they would report or withhold their selected answer in different social contexts: formal vs. informal, that could be either constrained (a context that promotes providing only responses we are certain about) or loose (with an incentive structure that maximizes providing any type of answer). Overall, our results confirmed that social contexts are associated with different incentive structures which affects memory reporting strategies. We also found that the difficulty of the questions is an important factor in conversational pragmatics. Our results highlight the relevance of studying different incentive structures of social contexts to understand the underlying processes of conversational pragmatics, and stress the importance of considering metamemory theories of memory reporting.
Mixed comparison of interventions for different exercise types on students with Internet addiction: a network meta-analysis
Authors: Zhang Yihan , Li Geng , Liu Chengzhen , Chen Huohong , Guo Jianping , Shi Zifu
Published: May 2023

Background

Internet addiction (IA) has a significant negative impact on students. The condition of students with IA can be improved by exercise, which has been identified as an effective intervention strategy. However, the relative effectiveness of different exercise types and the most effective ones remains unknown. This study presents a network meta-analysis to compare six exercise types (team sport, double sport, single sport, team + double sport, team + single sport, and team + double + single sport) based on their effectiveness in reducing Internet addiction and maintaining mental health.

Methods

Systematic searches were conducted in PubMed, EMBASE, Cochrane Library, CNKI, Wan Fang, CQVIP, Web of Science, CBM, EBSCO, APA PsycNet, and Scopus, and all relevant studies from the beginning to 15 July 2022 were included on. According to the Cochrane Handbook 5.1.0 Methodological Quality Evaluation Criteria, the listed studies' bias risk was assessed, while the network meta-analysis was performed using STATA 16.0.

Results

A total of 39 randomized controlled trials that met all inclusion criteria including 2,408 students with IA were examined. The meta-analysis results showed that compared with the control group, exercising significantly improved loneliness, anxiety, depression, and interpersonal sensitivity (p < 0.05). Specifically, the network meta-analysis discovered that the single sport, team sport, double sport, team + double sport, and team + double + single sport had significant effects on improving Internet addiction as compared to the respective control group (p < 0.05); the single sport, team sport, and double sport tend to be effective compared with controls in improving mental health (p < 0.05). Compared with the other five types of sports, the double sport was ranked first and showed the greatest potential to be the best choice (cluster ranking value = 3699.73) in improving Internet addiction (SUCRA = 85.5) and mental health (SUCRA = 93.1).

Conclusion

Exercise could be suggested as the best alternative when treating IA in students, based on the extensive positive effects of exercise on IA, anxiety, depression, interpersonal sensitivity, loneliness, and mental health in IA students. Double sport may be the best type of exercise for Internet-addicted students. However, to further examine the benefits of exercise for IA students, more research is required.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=377035, identifier: CRD42022377035.
Motivating factors and barriers to help-seeking for casino gamblers: results from a survey in Swiss casinos
Authors: Lischer Suzanne , Schwarz Jürg , Wallimann Hannes , Jeannot Emilien , Mathys Jacqueline
Published: May 2023

Introduction

Gambling can have serious consequences for many aspects of a person’s life. Yet relatively few people with gambling problems seek help. This study examines the extent to which exclusion from casino venues among other factors may act as a motivator for further help-seeking among casino gamblers (both landbased and remote) with at-risk or disordered gambling behavior. In addition, the barriers that prevent gamblers from accepting help are examined.

Methods

Gamblers from Swiss casinos completed a written questionnaire twice, at 6-month intervals. The questions included whether they had sought help in the past 6 months.

Results

For those with a SOGS-R rating of 1 or over (n = 173) at the second survey point, a difference in help-seeking was found between the excluded and non-excluded gamblers (p < .001), suggesting that exclusion may be a motivator for help-seeking. Reported differences in levels of debt (p = .006), recognition of gambling problems (p = .010) and severity of gambling-related problems (p = .004) can be taken to suggest that other motivating factors may also influence help-seeking behavior. With regard to the support sought, the most frequently used forms of support were specialized addiction counseling centers (39.5%), followed by self-help groups (21.1%) and remote counseling centers (10.5%). In terms of barriers, reasons relating to attitude, such as denial, appear to pose greater barriers than treatment-related concerns.

Discussion

From a public health perspective, an overarching strategy is required to increase the share of help-seekers among casino gamblers through targeted measures.
Altered gut microbiota profile in patients with perimenopausal panic disorder
Authors: Lin Shen , Wang Hongjin , Qiu Jingjing , Li Minghong , Gao Ebin , Wu Xiaofeng , Xu Yunxiang , Chen Guizhen
Published: May 2023

Introduction

Females in the perimenopausal period are susceptible to mood disorders. Perimenopausal panic disorder (PPD) is characterized by repeated and unpredictable panic attacks during perimenopause, and it impacts the patient's physical and mental health and social function. Pharmacotherapy is limited in the clinic, and its pathological mechanism is unclear. Recent studies have demonstrated that gut microbiota is strongly linked to emotion; however, the relation between PPD and microbiota is limitedly known.

Methods

This study aimed to discover specific microbiota in PPD patients and the intrinsic connection between them. Gut microbiota was analyzed in PPD patients (n = 40) and healthy controls (n = 40) by 16S rRNA sequencing.

Results

The results showed reduced α-diversity (richness) in the gut microbiota of PPD patients. β-diversity indicated that PPD and healthy controls had different intestinal microbiota compositions. At the genus level, 30 species of microbiota abundance had significantly different between the PPD and healthy controls. In addition, HAMA, PDSS, and PASS scales were collected in two groups. It was found that Bacteroides and Alistipes were positively correlated with PASS, PDSS, and HAMA.

Discussion

Bacteroides and Alistipes dysbiosis dominate imbalanced microbiota in PPD patients. This microbial alteration may be a potential pathogenesis and physio-pathological feature of PPD. The distinct gut microbiota can be a potential diagnostic marker and a new therapeutic target for PPD.
Usability and acceptability testing of a Plan of Safe Care in a mobile health platform
Authors: Isaacs Krystyna R. , Bajracharya Elina , Taylor Shantae , Chang Katie , Washio Yukiko , Parker Trenee , Paul David A. , Ma Tony X.
Published: May 2023

Purpose

Women who are pregnant or parenting while recovering from substance use disorder (SUD) are at risk for insufficient recovery support. With the federal mandate, implementation has been left to each state for the Plan of Safe Care (POSC), leading to challenges in providing comprehensive care coordination and meeting federal reporting requirements.

Methods

This research tests the usability and acceptability of a POSC platform, called SAFE4BOTH, which combines a mobile health (mHealth) app for use by mothers with substance use disorder (MSUD) with a web-based case management system for use by stakeholders to reduce the issue of fragmented postnatal maternal and infant care. The platform was designed to enable access to services, improve reporting task workflow, and assist in improving interactions between mothers and service providers.

After applying a user-centered design approach, the usability and acceptability of the SAFE4BOTH platform were evaluated using focus groups, interviews, and a System Usability Scale (SUS). The evaluation involved four staff members from a Medication for Addiction Treatment clinic (comprising of three case management workers and one peer counselor), four state employees of the Delaware Division of Family Services, and 20 mothers with MSUD who had delivered infants in need of a POSC.

Features tested in the SAFE4BOTH platform included a secure, web-based POSC, a contingency management-based reward system, a micro-learning library, a resources locator, a chat messaging and videoconferencing system, a directory for contact management, a QR code reader, use of an appointment compliance system engaging geofencing, and an enhanced calendar. Family services and treatment center staff accessed SAFE4BOTH from their laptops or tablets, and MSUD accessed SAFE4BOTH from their phones.

Results

Family services staff, treatment center staff, and MSUD participants rated SAFE4BOTH as usable and acceptable with average System Usability Scale scores of 68.1 (SD 8.5), 92.5 (SD 11.73), and 78.4 (SD 12.5) (respectively).

Conclusion

The platform was judged both usable and acceptable by all three target populations (family services staff, treatment center staff, and MSUD). Further studies are planned to explore the efficacy of longitudinally supporting the mother’s recovery and the infant’s healthy development.
Association between metabolically healthy obesity and kidney stones: results from the 2011–2018 National Health and Nutrition Examination Survey
Authors: Chen Weinan , Man Sailimai , Hong Yang , Kadeerhan Gaohaer , Chen Liang , Xu Qingquan , Xiong Liulin , Xu Tao , Wang Bo , Huang Xiaobo
Published: May 2023

Introduction

The risk of kidney stones in metabolically healthy obesity (MHO) individuals is largely unexplored. This study using percent body fat (%BF) to categorize obesity, to investigate the association between MHO as well as other metabolic syndrome-obesity combined phenotypes and kidney stones in a national representative population.

Materials and methods

This cross-sectional study included 4,287 participants in the National Health and Nutrition Examination Survey from 2011 to 2018. Metabolically healthy status was defined as not having any component of metabolic syndrome or insulin resistance. Obesity was identified by %BF, which was measured and assessed by dual-energy x-ray absorptiometry (DXA) scan. Participants were cross-classified by metabolic health and obesity status. The outcome was self-report kidney stones. Multivariable logistic regression model was used to examine the association between MHO and kidney stones.

Results

A total of 358 participants had kidney stones [weighted prevalence (SE): 8.61% (0.56%)]. The weighted prevalence (SE) of kidney stones in MHN, MHOW, and MHO groups was 3.13% (1.10%), 4.97% (1.36%), and 8.55% (2.09%), respectively. After adjusting for age, sex, race and ethnicity, education level, smoking status, alcohol consumption, physical activity, daily water intake, CKD stage 3–5, and hyperuricemia, MHO individuals (OR: 2.90, 95% CI: 1.18, 7.0) had a significantly higher risk of kidney stones than those with metabolically healthy normal weight. In metabolically healthy participants, a 5% increment in %BF was associated with a significantly higher risk of kidney stones (OR: 1.60, 95% CI: 1.20, 2.14). Furthermore, a nonlinear dose–response relationship between %BF and the kidney stones was observed in metabolically healthy participants (P for non-linearity = 0.046).

Conclusion

Using %BF to define obesity, MHO phenotype was significantly associated with higher risks of kidney stones, suggesting that obesity can independently contribute to kidney stones in the absence of metabolic abnormalities and insulin resistance. Regarding kidney stones prevention, MHO individuals might still benefit from lifestyle interventions aimed at healthy body composition maintenance.
Critical air pollutant assessments and health effects attributed to PM2.5 during and after COVID-19 lockdowns in Iran: application of AirQ+ models
Authors: Ghobakhloo Safiye , Khoshakhlagh Amir Hossein , Mostafaii Gholam Reza , Chuang Kai-Jen , Gruszecka-Kosowska Agnieszka , Hosseinnia Pariya
Published: May 2023

Objectives

The aim of this study was to evaluate changes in air quality index (AQI) values before, during, and after lockdown, as well as to evaluate the number of hospitalizations due to respiratory and cardiovascular diseases attributed to atmospheric PM2.5 pollution in Semnan, Iran in the period from 2019 to 2021 during the COVID-19 pandemic.

Methods

Daily air quality records were obtained from the global air quality index project and the US Environmental Protection Administration (EPA). In this research, the AirQ+ model was used to quantify health consequences attributed to particulate matter with an aerodynamic diameter of <2.5 μm (PM2.5).

Results

The results of this study showed positive correlations between air pollution levels and reductions in pollutant levels during and after the lockdown. PM2.5 was the critical pollutant for most days of the year, as its AQI was the highest among the four investigated pollutants on most days. Mortality rates from chronic obstructive pulmonary disease (COPD) attributed to PM2.5 in 2019–2021 were 25.18% in 2019, 22.55% in 2020, and 22.12% in 2021. Mortality rates and hospital admissions due to cardiovascular and respiratory diseases decreased during the lockdown. The results showed a significant decrease in the percentage of days with unhealthy air quality in short-term lockdowns in Semnan, Iran with moderate air pollution. Natural mortality (due to all-natural causes) and other mortalities related to COPD, ischemic heart disease (IHD), lung cancer (LC), and stroke attributed to PM2.5 in 2019–2021 decreased.

Conclusion

Our results support the general finding that anthropogenic activities cause significant health threats, which were paradoxically revealed during a global health crisis/challenge.
Understanding the system dynamics of obesity-related behaviours in 10- to 14-year-old adolescents in Amsterdam from a multi-actor perspective
Authors: Luna Pinzon Angie , Stronks Karien , Emke Helga , van den Eynde Emma , Altenburg Teatske , Dijkstra S. Coosje , Renders Carry M. , Hermans Roel , Busch Vincent , Chinapaw Mai J. M. , Kremers Stef P. J. , Waterlander Wilma
Published: May 2023

Introduction and Methods

To develop an understanding of the dynamics driving obesity-related behaviours in adolescents, we conducted systems-based analysis on a causal loop diagram (CLD) created from a multi-actor perspective, including academic researchers, adolescents and local stakeholders.

Results

The CLD contained 121 factors and 31 feedback loops. We identified six subsystems with their goals: (1) interaction between adolescents and the food environment, with profit maximisation as goal, (2) interaction between adolescents and the physical activity environment, with utility maximisation of outdoor spaces as goal, (3) interaction between adolescents and the online environment, with profit maximisation from technology use as goal, (4) interaction between adolescents, parenting and the wider socioeconomic environment, with a goal focused on individual parental responsibility, (5) interaction between healthcare professionals and families, with the goal resulting in treating obesity as an isolated problem, and (6) transition from childhood to adolescence, with the goal centring around adolescents’ susceptibility to an environment that stimulates obesity-related behaviours.

Discussion

Analysis showed that inclusion of the researchers’ and stakeholders’ perspectives contributed to an understanding of how the system structure of an environment works. Integration of the adolescents’ perspective enriched insights on how adolescents interact with that environment. The analysis further showed that the dynamics driving obesity-related behaviours are geared towards further reinforcing such behaviours.
Toward urban-rural linkage development: contribution of climate-adaptive agroecology in the lower Chao Phraya River Basin, Thailand
Authors: Hongsprabhas Parichat
Published: May 2023

This case study proposed a hypothesis on initiating urban-rural co-development using food as a medium to drive the transformation of the food systems and sustainable consumption. The guiding principles of the United Nations Habitat to the water-retention areas under the nature-based solution (NBS) for flood mitigation in Thailand's central region, the main rice-growing area, were applied. This study reviewed the partnerships of primary institutions, namely public, private, and universities, supporting and intertwining with civil society through Thai cultural and social norms after the 1997 economic crisis. The critical aspects included the sufficiency economy (SE) philosophy at the household level as a foundation of national policies. Recent policies and measures on food and nutrition security, alternative farming practices, and incentives to increase sustainable agroecology were prioritized post-COVID-19. This research suggests additional measures enabling agroecology and landscape improvement in rural areas connecting the cities of Ayutthaya and Bangkok to enhance market access for small producers and consumers in rural and urban areas with limited resources. A better community-based adaptation, ecological outcomes, and sustainable social inclusion in flood-prone lowlands could support Thailand's food sovereignty and capacity-building as one of the world's major food exporters under climate extremes.
Patient characteristics, symptoms, and urodynamic parameters associated with detrusor contraction duration in women
Authors: Wang Connie N. , Ha Albert , Chung Doreen E.
Published: May 2023

Background

There is a lack of understanding of the clinical significance of detrusor contraction duration (DCD) measured on urodynamic studies (UDS). We aimed to identify patient characteristics, presenting symptoms and urodynamic parameters associated with DCD in women.

Methods

Using a single-institution database of UDS (2015-2019), 405 female patients with measurable detrusor contractions were identified. Baseline characteristics, presenting symptoms and UDS parameters were analyzed. Bladder outlet obstruction (BOO) was characterized using the Blaivas-Groutz nomogram. Wilcox Rank Sum Tests were used for descriptive statistics, and a univariable generalized linear model conforming to a gamma distribution was used.

Results

Median age was 65 years (IQR 52-75), BMI was 27.5 kg/m2 (IQR 23.9-31.1) and DCD was 90 seconds (IQR 57-124). On univariable analysis, degenerative disc disease (β = -17.9, p = 0.02), pelvic radiation (β = -31.91, p = 0.04), and stress incontinence (β = -14.11, p = 0.03) were associated with reduced DCD. Black race was associated with longer DCD (β = 22.92, p = 0.01). Analysis of UDS parameters revealed a significant increase in DCD per unit increase of bladder capacity (β = 0.08, p<0.001), detrusor pressure (Pdet) at maximum flow (Qmax) (β = 0.96, p<0.001), and maximum Pdet (β = 1.2, p<0.001). In contrast, a significant decrease in DCD was noted per unit increase in Qmax (β = -1.43, p<0.001). Finally, mild (β = 34.4, p<0.001), moderate (β = 72.52, p<0.001), and severe (β = 64.6, p<0.001) BOO were all associated with increased DCD.

Conclusions

Median DCD in women is 90 seconds. Longer DCD is associated with greater degree of BOO, higher maximum Pdet, Pdet at Qmax, and bladder capacity. Disc disease, irradiation and stress incontinence are associated with reduced DCD. Further studies are needed to evaluate the predictive value of DCD in women.
Women and cities. The conquest of urban space
Authors: Carrera Letizia , Castellaneta Marina
Published: May 2023

In the city of the Nineteenth-century, transformed by the values of the French revolution and by the modernity, women did not have yet full citizenship. The public space was still strongly a male space and women, still with a weak public subjectivity, remained the object of the male gaze. Women have begun a process of conquering urban space by claiming their right to the city, through their physical presence in the city itself. Through physical space, women have claimed their full symbolic citizenship. The project of an inclusive city takes shape from the public demands of women who, as Annie Hockshild wrote, gave birth to the most important revolution of the 20th century. However it is a stalled revolution that still today requires a legislative protection for the project of the substantial equality, which is still not fully achieved. In addition to the various national legislations, international legislation also recognizes the central objective of guaranteeing women's right to full citizenship. In the second part of the article, the focus is precisely on the normative content of this legislation and in particular on the objectives of the UN Agenda 2030.
Direct dotterising or angioplasty of acute stroke due to tandem atherosclerotic occlusions
Authors: Yeo Leonard L. L. , Simonato Davide , Bhogal Pervinder , Gopinathan Anil , Cunli Yang , Ong Samuel W. Q. , Jing Mingxue , Tan Benjamin Y. Q. , Sia Ching-Hui , Jia Tom , Cester Giacomo , Gabrieli Joseph-Domenico , Andersson Tommy
Published: May 2023

Background

Tandem occlusions cause 10–15% of LVO acute ischemic strokes but are difficult to treat endovascularly and frequently excluded from clinical trials. The optimum endovascular method is still debated, however going directly through the carotid occlusion can speed up the procedure and reduce procedural risk by eliminating an exchange maneuver.

Method

Using retrospective data from three centers, we compared treating atherosclerotic tandem occlusions using a 0.035'-guidewire and direct dotterisation or angioplasty with a peripheral vascular balloon suitable for the wire, vs. the usual technique of an 0.014'wire. We compared the successful recanalization (mTICI 2b-3) rates, 90 days' functional outcomes (mRS 0–2), and puncture-to-recanalization times between both procedures.

Results

Forty-two consecutive patients with atherosclerotic tandem occlusions were included; 25 were treated with the 0.014'wire technique and 17 with the 0.035'-guidewire and direct dotterisation or angioplasty with a peripheral vascular balloon technique. The direct technique achieved a higher rate of successful recanalization (100 vs. 72%, P = 0.018), better functional outcome (88.4 vs. 48.0%, P = 0.044), and faster procedure times (mean 65.1 mins vs. 114.8 mins, P < 0.001). The number of attempts was similar between both groups (median 2 vs 3 attempts, P = 0.101). There was no significant difference in the complication rate between both groups (5.9 vs. 12.0%, P = 0.462).

Conclusion

Compared to previous endovascular techniques for treating atherosclerotic tandem occlusions, the direct technique using standard 0.035' guidewires and dotterisation or a peripheral vascular balloon is significantly faster with better outcomes. However, this will require further external validation in larger cohorts.
Home garden interventions in crisis and emergency settings
Authors: Baliki Ghassan , Weiffen Dorothee , Moiles Gwendolyn , Brück Tilman
Published: May 2023

Homes gardens are a key source of food security and micronutrient-rich fruits and vegetables and are promoted by aid organizations to help households cope in humanitarian emergencies. However, there is a strong divide between the popularity of home gardens among practitioners and the academic evidence of its nutritional, economic, social and political outcomes. This review provides a comprehensive summary of the evidence about home garden interventions in crisis settings using a three-pronged approach, triangulating evidence from academic literature, expert discussion (World Café) and a practitioner survey. Our findings show a significant gap between existing research evidence on one hand, and the needs and current practices on the other, particularly where theories and impact pathways of home garden interventions might not hold in crises-affected settings.
A novel Laennec's capsule tunnel approach for pure laparoscopic left hemihepatectomy: a propensity score matching study
Authors: Lai Jianlin , Wu Junyi , Bai Yannan , Tian Yifeng , Wang Yaodong , Qiu Funan
Published: May 2023

Background

With the development of laparoscopic hepatectomy, there are different surgical approaches and pedicle anatomical methods for laparoscopic left hepatectomy. Combined with our practical experience, we proposed a method of transhepatic Laennec membrane tunnel for laparoscopic left hemihepatectomy (LT-LLH) and investigated the feasibility by comparison with the extrahepatic Glissonian approach for laparoscopic left hemihepatectomy (GA-LLH).

Patients and methods

The data of patients who underwent laparoscopic left hepatectomy in the Department of Hepatobiliary Pancreatic surgery of Fujian Provincial Hospital from December 2019 to March 2022 were analyzed retrospectively. Among them, 45 cases underwent laparoscopic left hemihepatectomy with an extrahepatic Glissonian approach, and 38 cases underwent laparoscopic left hemihepatectomy via transhepatic Laennec membrane tunnel approach. A 1:1 propensity score matching (PSM) method was performed to compare the perioperative indexes and long-term tumor prognosis between the two groups.

Results

After 1:1 PSM, 33 patients in each group were selected for further analysis. Compared with the GA-LLH group, the operation time of the LT-LLH group was shorter. There was no significant difference in the incidence of total complications between the two groups. Moreover, no statistical differences were found in disease-free survival and overall survival between the two groups.

Conclusion

It is safe, faster, and convenient for selective appropriate cases to carry out laparoscopic left hemihepatectomy through the hepatic Laennec membrane tunnel, which is suitable for clinical promotion.
Intradiaphragmatic pulmonary sequestrations: a surgical challenge. Case series
Authors: Oreglio Chiara , Tocchioni Francesca , Ghionzoli Marco , Buccoliero Annamaria , Morabito Antonino , Morini Francesco
Published: May 2023

Bronchopulmonary sequestrations (BPSs) are rare congenital anomalies characterized by non-functioning embryonic lung tissue receiving anomalous blood supply. They are most commonly located within the thorax (supradiaphragmatic) or into the abdominal cavity (infradiaphragmatic). Intradiaphragmatic extralobar BPs (IDEPS) are an exceptionally rare finding, representing a diagnostic and operative challenge. We report three cases of IDEPS and their surgical management, describing our experience and approach to such rare clinical entities. From 2016 to 2022, we treated 3 cases of IDEPS. Surgical techniques, histopathological findings and clinical outcomes were retrospectively evaluated for each case and compared. Three different surgical techniques were used to approach each lesion, from open thoracotomy to a combined laparoscopic and thoracoscopic approach. Histopathological analysis of the specimens revealed hybrid pathological features, proper of both congenital pulmonary airway malformation (CPAM) and extralobar pulmonary sequestration. IDEPS represent a surgical challenge for pediatric surgeons, given their complex surgical planning. In our experience, the thoracoscopic approach is safe and feasible when performed by trained surgeons, even though a combined thoracoscopic-laparoscopic approach allows for optimal vessels control. The presence of CPAM elements within the lesions supports their surgical removal. Additional studies are required to better characterize IDEPS and their management.
Clonal relation between Salmonella enterica subspecies enterica serovar Dublin strains of bovine and food origin in Germany
Authors: Linde Jörg , Szabo Istvan , Tausch Simon H. , Deneke Carlus , Methner Ulrich
Published: May 2023

Salmonella enterica subspecies enterica serovar Dublin (S. Dublin) is a host-adapted serovar causing enteritis and/or systemic diseases in cattle. As the serovar is not host-restricted, it may cause infections in other animals, including humans with severe illness and higher mortality rates than other non-typhoidal serovars. As human infections are mainly caused by contaminated milk, milk products and beef, information on the genetic relationship of S. Dublin strains from cattle and food should be evaluated. Whole-genome sequencing (WGS) of 144 S. Dublin strains from cattle and 30 strains from food origin was performed. Multilocus sequence typing (MLST) revealed mostly sequence type ST-10 from both, cattle and food isolates. In total, 14 of 30 strains from food origin were clonally related to at least one strain from cattle, as detected by core-genome single nucleotide polymorphisms typing as well as core-genome MLST. The remaining 16 foodborne strains fit into the genome structure of S. Dublin in Germany without outliers. WGS proved to be a powerful tool not only to gain information on the epidemiology of Salmonella strains but also to detect clonal relations between organisms isolated from different stages of production. This study has shown a high genetic correlation between S. Dublin strains from cattle and food and, therefore, the potential to cause human infections. S. Dublin strains of both origins share an almost identical set of virulence factors, emphasizing their potential to cause severe clinical manifestations in animals, but also in humans and thus the need for effective control of S. Dublin in a farm-to-fork strategy.
Organ Donation in Croatia: The Importance of a National Champion, a Comprehensive Plan, and International Collaborations
Authors: Mah Jasmine , Johnston-Webber Charlotte , Prionas Apostolos , Bušić Mirela , Streit Simon , Wharton George , Mossialos Elias , Papalois Vassilios
Published: May 2023

The Republic of Croatia is a global leader in organ donation and transplantation despite having fewer resources and more modest healthcare expenditures than other countries in the European Union. The results of an extensive literature review were combined with expert input in an iterative multi-step data collection and evaluation process designed to assess trends in Croatian organ donation and transplantation and identify key elements, policy changes, and drivers of the system that have contributed to its success. Multiple sources of evidence were used in this study, including primary documents, national and international transplantation reports, and insights from critical informants and content experts. The results highlight several key organizational reforms that have substantially improved the performance of the Croatian transplant program. Our findings emphasize the importance of strong central governance led by an empowered national clinical leader acting under the direct auspices of the Ministry of Health and a comprehensive and progressive national plan. The Croatian transplant system is notable for its integrated approach and efficient manner of managing scarce health resources. Collectively, the results suggest that Croatia has become nearly self-sufficient due to its systematic implementation of the guiding principles for organ donation and transplantation.
Twenty-Years Journey of Sustainable Human Resource Management Research: A Bibliometric Analysis
Authors: Faisal Shaha
Published: May 2023

Sustainability is gaining acceptance worldwide, and HRM is also influenced by it. Researchers globally are also exploring sustainable human resource management which creates a direct link between HRM and sustainability. Bibliometric analysis examined 247 documents on sustainable human resource management from 2003 to 2022. This study aimed to analyze the research trend, global distribution, contributory journals, leading authors, and contributing nations in sustainable HRM. In this bibliometric analysis, 247 documents have been analyzed. The review revealed that sustainable HRM is still an emerging concept worldwide; more researchers from European and Asian countries dominate this field. The present review will be helpful for academicians, practitioners, and researchers in this field. The study also presents interesting results that could help line managers and top managers to formulate ideas for sustainable HRM practices in their own companies.
Improvement in Wheat Productivity with Integrated Management of Beneficial Microbes along with Organic and Inorganic Phosphorus Sources
Authors: Nadia  , Amanullah  , Arif Muhammad , Muhammad Dost
Published: May 2023

Phosphorus (P) unavailability in agricultural soils is a primary cause of the poor development and yield of field crops in arid and semiarid regions. The primary goal of this research project was to investigate the influence of integrated management of beneficial microbes or biofertilizers (BF), organic P-fertilizers, and inorganic P-fertilizers on wheat productivity in a wheat–maize cropping system. Field experiments were carried out during the two consecutive seasons of 2020/2021 (Y1) and 2021/2022 (Y2) according to the two-factorial randomized complete block design with three replications. Factor one consisted of twenty-one treatments of organic and inorganic P-fertilizer combinations, while factor two consisted of two different BF (PSB and Bioaab). One overall control where no P or BF was applied was also included in each replication for comparison. The experiment consisted of six treatments of sole P sources (sheep manure (SM), cattle manure (CM), legume residues (LR), non-legume residues (NLR), single super phosphate (SSP) and rock phosphate (RP)), each applied at a rate of 90 kg P ha−1. Different combinations of organic and inorganic P sources (giving 15 treatments) were applied at a rate of 50% P from each source (i.e., 45 kg P ha−1 applied from different sources in combination). The results revealed that the combined application of SSP+SM produced a significantly higher number of grains spike−1 (23.9%), spikes m−2 (4.5%), and grain yield (40.9%) over the control. Application of PSB produced the maximum number of grains spike−1 (23.9%), spikes m−2 (4.5%), thousand-grain weight (8.3%), grain yield (40.9%), and biological yield (17%) in the wheat crop as compared to Bioaab. It was concluded from the two-year study that integrated use of organic P-fertilizers (animal manures) plus inorganic P-fertilizer (SSP) along with PSB ranked first in terms of higher wheat productivity in a wheat–maize cropping system.
Induction of Polyploidy in Citrus Rootstocks through In Vitro Colchicine Treatment of Seed-Derived Explants
Authors: Narukulla Vijayakumari , Lahane Yogesh , Fiske Krutika , Pandey Shashi , Ziogas Vasileios
Published: May 2023

Polyploidy, frequently observed in citrus species, aids in achieving better adaptation to environmental stresses. In this context, the current work aims to develop stable tetraploids in citrus rootstock cultivars, viz., Rough lemon, Rangpur lime and Alemow, through in vitro colchicine treatments. Seed-derived explants were obtained by culturing sterile seeds on MS basal media. Seedlings with a size of 5–8 mm (hypocotyl) were exposed to colchicine treatment. After treatment, the surviving seedlings were minigrafted onto six-month-old rootstock for better growth. Colchicine concentrations of 0.1%, 0.2%, 0.3% and control for durations of 16 or 24 h were tested with respect to the induction of polyploidisation. Treatment with 0.1% colchicine for 24 h resulted in high rates of mutation for polyploidisation and showed the highest tetraploid induction percentage (18.3%) in all the rootstock cultivars. High colchicine concentration and long exposure time decreased the survival of the observed seedlings. Flow cytometry and cytological methods were used for confirmation of autotetraploidy in the analysed samples. The surviving seedlings were identified on the basis of morphological and cytological variables, such as leaf area and stomata size, which significantly increased with increasing ploidy level. The proposed method was found to be an effective way to induce the polyploidy in Rangpur lime, Rough lemon and Alemow rootstocks.
Genotypic Response of Finger Millet to Zinc and Iron Agronomic Biofortification, Location and Slope Position towards Yield
Authors: Teklu Demeke , Gashu Dawd , Joy Edward J. M. , Lark R. Murray , Bailey Elizabeth H. , Wilson Lolita , Amede Tilahun , Broadley Martin R.
Published: May 2023

The present study aimed to investigate the influence of genotypic differences on responses to zinc and iron agronomic biofortification among yields of finger millet. A field experiment was conducted over two seasons in farmers’ fields in Ethiopia (2019, 2020). The experimental design had 15 treatment combinations comprising three finger millet genotypes and the applications of different combinations of zinc and iron mineral fertilizers. Five soil-applied fertilizer treatments (20 kg h−1 FeSO4 + 25 kg h−1 ZnSO4 + NPKS, 25 kg ha−1 ZnSO4 + NPKS, 20 kg ha−1 FeSO4 + NPKS, NPKS, and 30% NPKS) at two locations (Gojjam and Arsi Negelle, Ethiopia) and using two slope positions (foot and hill) were replicated four times in a randomized complete block design. Grain yield and biomass were evaluated on a plot basis. Plant height, total and productive tiller number, finger length of the longest spike and number of fingers per main ear were measured at the maturity stage. The combined soil application of FeSO47H2O and ZnSO47H2O increased the yield of the Meba genotype by 51.6%. Additionally, ZnSO47H2O fertilizer application increased the yield of the Urji genotype by 27.6%. A yield enhancement of about 18.3% of the Diga-01 genotype was achieved due to the FeSO47H2O fertilizers’ application. The findings of the present study suggest that the influence of Zn and Fe agronomic biofortification on the yield of finger millet could be affected by genotype differences and environmental conditions.