bluuebunny/crossref_metadata_2025 huggingface dataset:
Experiences and perceptions of conditional cash incentive provision and cessation among people with HIV for care engagement: A qualitative study
Authors: Giordano Julia , Lewis-Kulzer Jayne , Montoya Lina , Akama Eliud , Adhiambo Harriet Fridah , Nyadieka Everlyne , Iguna Sarah , Bukusi Elizabeth A. , Odeny Thomas , Camlin Carol S. , Thirumurthy Harsha , Petersen Maya , Geng Elvin H.
Published: February 2024

Background
Consistent engagement in HIV treatment is needed for healthy outcomes, yet substantial loss-to-follow up persists, leading to increased morbidity, mortality and onward transmission risk. Although conditional cash transfers (CCTs) address structural barriers, recent findings suggest that incentive effects are time-limited, with cessation resulting in HIV care engagement deterioration. We explored incentive experiences, perceptions, and effects after cessation to investigate potential mechanisms of this observation.
Methods
This qualitative study was nested within a larger trial, AdaPT-R (NCT02338739), focused on HIV care engagement in western Kenya. A subset of participants were purposively sampled from AdaPT-R participants: adults with HIV who had recently started ART, received CCTs for one year, completed one year of follow-up without missing a clinic visit, and were randomized to either continue or discontinue CCTs for one more year of follow-up. In-depth interviews were conducted by an experienced qualitative researcher using a semi-structed guide within a month of randomization. Interviews were conducted in the participants’ preferred language (Dholuo, Kiswahili, English). Data on patient characteristics, randomization dates, and clinic visit dates to determine care lapses were extracted from the AdaPT-R database. A codebook was developed deductively based on the guide and inductively refined based on initial transcripts. Transcripts were coded using Dedoose software, and thematic saturation was identified.
Results
Of 38 participants, 15 (39%) continued receiving incentives, while 23 (61%) were discontinued from receiving incentives. Half were female (N = 19), median age was 30 years (range: 19–48), and about three-quarters were married or living with partners. Both groups expressed high intrinsic motivation to engage in care, prioritized clinic attendance regardless of CCTs and felt the incentives expanded their decision-making options. Despite high motivation, some participants reported that cessation of the CCTs affected their ability to access care, especially those with constrained financial situations. Participants also expressed concerns that incentives might foster dependency.
Conclusions
This study helps us better understand the durability of financial incentives for HIV care engagement, including when incentives end. Together with the quantitative findings in the parent AdaPT-R study, these results support the idea that careful consideration be exercised when implementing incentives for sustainable engagement effects.
MiR-129-5p inhibits the proliferation, migration, and invasion of U87 glioblastoma cells by targeting CaMK IV via the MAPK signaling pathway
Authors: Gong Haidong , Yu Tao , Jin Lijiao , Zheng Fakang , Wang Weining , Lv Bo , Zhao Qiwen , Liu Danian
Published: February 2024

Objective
The purpose was to investigate the expression of CaMK IV in glioblastoma (GBM) and its specific role in GBM cell proliferation, invasion, migration, and other malignant phenotypes. Furthermore, this study aimed to validate the functional relationship between miR-129-5p and CaMK IV, then explore the underlying molecular mechanisms involved.
Results
Bioinformatics analysis revealed that CaMK IV was expressed at higher levels in normal brain tissues than in GBM tissues. qRT-PCR demonstrated significantly lower expression of CaMK IV in GBM cell samples than in the control tissue. CCK-8 assays indicated that overexpression of CaMK IV significantly inhibited the activity and proliferation of U87 GBM cells, while knockdown of CaMK IV had the opposite effect. Similarly, the introduction of miR-129-5p mimics inhibited the activity and proliferation of U87 GBM cells, while the use of a miR-129-5p inhibitor yielded the opposite results. The scratch assay revealed that, compared with control treatment, CaMK IV overexpression led to larger scratch areas at 12 and 24 hours, indicating that CaMK IV has an inhibitory effect on the migration ability of the GBM cell line U87. Conversely, knockdown of CaMK IV had the opposite effect. Moreover, Transwell assays demonstrated that the overexpression of CaMK IV resulted in significantly fewer penetrating cells than was observed in the control group, suggesting that CaMK IV has an inhibitory effect on the invasion ability of U87 GBM cells. Again, knockdown of CaMK IV yielded the opposite results. Western blot analysis revealed that the overexpression of CaMK IV significantly suppressed the expression of proliferation-related proteins while promoting the activity of apoptosis-related proteins in the U87 GBM cell line. Moreover, overexpression of CaMK IV inhibited the phosphorylation of the MAPK pathway-related proteins JNK and P38, indicating CaMK IV has an inhibitory effect on GBM cells via the MAPK signaling pathway.
Conclusion
MiR-129-5p selectively inhibits the proliferation, migration, and invasion of U87 cells by targeting CaMK IV via the MAPK signaling pathway. MiR-129-5p and CaMK IV play an important inhibitory roles in GBM and may serve as potential therapeutic targets for GBM treatment.
Evaluating the impact of point-of-care electroencephalography on length of stay in intensive care unit: Sub analysis of SAFER Trial
Authors: Desai Masoom , Aparicio Mariel , Sheikh Irfan , Cormier Justine , Gallagher Kaileigh , Hussein Omar , Cespedes Jorge , Hirsch Lawrence J , Westover Brandon , Struck Aaron
Published: February 2024

Background: Electroencephalography (EEG) is needed to diagnose nonconvulsive seizures (NCS). Prolonged NCSs are associated with neuronal injuries and deleterious clinical outcomes.
However, it is uncertain whether the rapid identification of these seizures using point-of-care EEG (POC-EEG) can have a positive impact on clinical outcomes.
Methods: In a retrospective cohort sub-analysis of the recently completed multicenter SAFER-EEG trial, we compared intensive care unit length of stay (ICU LOS), poor functional outcome (modified Rankin score (mRS) ≥ 4), and time to EEG between adult patients receiving an FDA-cleared POC-EEG (Ceribell, Inc) and those receiving conventional EEG (convEEG). Patient records from January 2018 to June 2022 at three different academic centers were reviewed focusing on EEG timing and clinical outcomes. Propensity score matching was applied utilizing key clinical covariates to control for confounders. Medians and quartiles (25th and 75th) were calculated for descriptive statistics. Non-parametric tests (Mann-Whitney U) were used for the continuous variables, and Chi-square test for the proportions.
Results: A total of 283 ICU patients (62 convEEG, 221 POC-EEG) were included. The two populations were matched using demographic and clinical characteristics. We found that the ICU LOS was significantly shorter in the POC-EEG cohort compared to convEEG cohort (3.9 (IQR: 1.9-8.8) vs. 8.0 (3.0-16.0) days, p = 0.003). Moreover, mRS functional outcomes were also different between the two EEG cohort groups (p =0.047*).
Conclusion: This study reveals a significant association between early POC-EEG detection of NCSs and decreased ICU-LOS. The POC-EEG differed from conv-EEG demonstrating better functional outcomes compared to the latter in a matched analysis. These findings corroborate previous research advocating the benefit of early diagnosis of NCS. Causal relationship between type of EEG and metrics of interest such as ICU-LOS, functional/clinical outcomes need to be confirmed in future prospective randomized studies.
Influence of grafting materials on free gingival graft survival and alveolar ridge maintenance in socket seal procedures: a randomized controlled clinical trial
Authors: Kusuvan Pitcha , Leepong Narit , Suttapreyasri Srisurang
Published: February 2024

Purpose
This study aimed to investigate the viability of free gingival grafts (FGG) and assess clinical and radiographic changes in the alveolar ridge following socket seal surgery with or without bone graft.
Materials and methods
Twenty-eight anterior and premolar tooth extractions were randomly allocated to 2 groups: socket graft of freeze-dried bone allograft (FDBA) sealed with FGG (n = 15) and control with empty sockets sealed solely with FGG (n = 13). Photographs taken at 3, 7, 14, and 30 days post-surgery assessed FGG viability. Alveolar ridge volume was clinically evaluated via intraoral scanners before surgery and at 1 and 3 months post-surgery. CBCT scans taken immediately post-surgery and 3 months later assessed alveolar ridge dimensions.
Results
FGG viability in both groups increased from day 3 and reached the maximum score on day 14. Alveolar ridge volume reduction at 3 months in the FDBA group was comparable to the control group. Buccal alveolar bone height reduction was significantly higher in the FDBA group than the control group, while palatal alveolar bone height was comparable. Alveolar bone width reduction was evident but not statistically significant between the groups. The FDBA group exhibited a significant alteration in bone volume compared to the control group.
Conclusion
Viability of FGG was not affected by graft filling materials. Sealing the socket with FGG effectively preserved socket integrity and ridge volume in minor socket defects using either graft filling material or not. This study was registered on 4 January 2021 on Thai Clinical Trials Registry (TCTR20210104001).
Balanced Butterfly Counting in Bipartite-Network
Authors: Das Apurba , Abidi Aman , Kiran Mekala , Shingane Ajinkya
Published: February 2024

Bipartite graphs offer a powerful framework for modeling complex relationshipsbetween two distinct types of vertices, incorporating probabilistic, temporal, andrating-based information. While the research community has extensively exploredvarious types of bipartite relationships, there has been a notable gap in studyingSigned Bipartite Graphs, which capture liking/ disliking interactions in real-worldnetworks such as customer-rating-product and senator-vote-bill. Balance but-terflies, representing 2 × 2 bicliques, provide crucial insights into antagonisticgroups, balance theory, and fraud detection by leveraging the signed information.However, such applications require counting balance butterflies which remainsunexplored. In this paper, we propose a new problem: counting balance butterfliesin a signed bipartite graph. To address this problem, we adapt state-of-the-artalgorithms for butterfly counting, establishing a smart baseline that reduces thetime complexity for solving our specific problem. We further introduce a novelbucket approach specifically designed to count balanced butterflies efficiently. Wepropose a parallelized version of the bucketing approach to enhance performance.Extensive experimental studies on nine real-world datasets demonstrate that ourproposed bucket-based algorithm is up to 120x faster over the baseline, and theparallel implementation of the bucket-based algorithm is up to 45x faster over thesingle core execution. Moreover, a real-world case study showcases the practicalapplication and relevance of counting balanced butterflies.
Systemic immune inflammation index is a valuable marker for predicting hemodialysis patients with depression: a cross-sectional study
Authors: han xixi , 张 慧莹 , Kong Jing-wen , Liu Yu-xin , Zhang Ke-ren , Ren Wenying
Published: February 2024

Background：Maintenance hemodialysis(MHD) patients suffer from enormous physical, mental stress and poor quality of life, so an increasing number of patients are in a long-term state of depression. A prominent feature of MHD patients is chronic persistent inflammation, which is also an important mechanism for the onset of depression. Therefore, finding economically convenient inflammatory markers to predict and diagnose the onset of depression in MHD patients is of great value. As a novel inflammatory marker, systemic immune inflammation index(SII) can more comprehensively reflect the inflammation and immunity level of patients. This study aims to explore the relationship between SII and depressive symptoms in MHD patients.
Methods：A cross-sectional study was conducted on 208 MHD patients from three dialysis centers. Based on the Hospital Anxiety and Depression Scale(HADS) scores, patients were divided into non-depression and depression groups. Inter group comparison and multivariate logistic regression analysis were performed to determine whether SII is an independent risk factor for depression in MHD patients. Receiver operating characteristic(ROC) curve was used to evaluate the predictive value of SII on depression symptoms in MHD patients.
Results：38.83% of the included patients were in a state of depression. After adjusting for all confounding factors, MHD patients with SII>963.93 had a 4.709 times higher risk of depression than those with SII≤478.32 (OR=4.709, 95% CI 1.821-12.178, P<0.01). ROC analysis showed that SII>685.11 was the best cutoff value for MHD depression patients, and the area under the curve (AUC) was 0.681.
Conclusions：High SII is an independent risk factor for depressed MHD patients and an ideal inflammatory marker for predicting and identifying depression in MHD patients.
Study on vibration characteristics of suspension frame system for high temperature superconducting flux pinned maglev train under track irregularity harmonic excitation
Authors: Zhang Mingliang , Liu Liru , Shen Yongjun , Cui Kai
Published: February 2024

In order to avoid the abnormal vibration behavior of the high temperature superconducting flux pinned maglev train at high velocity (about 500 km/h to 600 km/h) due to the external interference from the suspension frame system, the vibration characteristics of suspension frame system under track irregularity harmonic excitation are studied. Firstly, the levitation force between the high temperature superconductor combination and the permanent magnet guideway (PMG) is measured by way of the quasi-static test platform, and the empirical formula of levitation force is obtained. Then, the nonlinear vibration differential equation of the suspension frame system under the track irregularity harmonic excitation is established. The first approximate solution is obtained based on the multi-scale method, which is verified by way of the numerical solution. Finally, the amplitude-frequency response equation of the suspension frame system under the primary resonance is derived, thus the influence of running velocity, track irregularity wavelength and amplitude on the steady-state amplitude is studied. An analytical method for determining the feasible domain of track irregularity parameters under different running velocity is proposed based on the safety standard of maglev train. The effective domain of track irregularity parameters can be obtained. The methodology and results of this manuscript provide a theoretical foundation for designing PMG for high temperature superconducting flux pinned maglev train.
Identification of PLMS Sleep Disorder using EEG Signal feature-based classification by Machine Learning Techniques
Authors: Tiwari Shivam , Arora Deepak , Nagar Vishal , Srivast Durgesh , Ahmed Suhaib , Das Jadav Chandra , Mallik Saurav , Shah Mohd Asif
Published: February 2024

It has been demonstrated that periodic leg movements during sleep (PLMS) are connected to alterations in features of EEG signal. Data mining evaluates hemispheric/cortical activity-related hemodynamic changes. We used data mining and machine learning to examine whether there are changes in brain hemodynamics associated with PLMS. Nighttime EEG recordings were made while brain activity was monitored in PLMS patients. Scores from EEG feature data were examined to find relevant differences. PLMS were consistently accompanied by variations in brain activity that increased in magnitude when related to changes in EEG and persisted even in the absence of any arousal that could be seen visually in the EEG. This study is the first to show PLMS-related alterations in brain activity. Clinical relevance of these observations has yet to be established. We have used wavelet decomposition with or without it to complete the aforementioned classification tasks. For binary disease to identify tasks employing the sleep stage of N3, we have achieved classification accuracy ranging between 92% and 96% and AUC ranging between 0.85 and 0.89. But, as the use of the suggested wavelet-based features is performed, a superior classification accuracy is achieved, with an AUC of 0.99 and a range of 94–98%. This is because the best wavelet-based features have a high degree of discrimination.
Perception and attitude of second-year medical and dental students at Gandaki Medical College regarding the use of a problem-based learning approach in basic medical sciences
Authors: Bista Soni , Paudel Sabita , Shrestha Bijayata , Subedi Nuwadatta , Basnyat Rupesh Shingh , Chettri Pradip
Published: February 2024

Background Problem-based learning (PBL) is a learner-centered pedagogical approach in which a person learns about a subject by working in groups to solve an open-ended problem. The objective of the present study was to assess students' perceptions and attitudes toward PBL and the role of tutors in PBL.Methods This quantitative study was conducted among second-year medical and dental undergraduate students from November 2022 to November 2023. The students were divided into eight groups, and each group was facilitated by tutors. A PBL tutor guide, with a case on the topic of diarrhea/dysentery, was designed as a module with six triggers and given to the groups. At the end of nine days of PBL sessions, feedback from students on the process of PBL and tutors was received using the 'Dolmans and Schmidt' and 'Dolmans and Ginns' questionnaires, respectively. The level of attitude of the students based on their feedback toward the PBL process and the tutors were also assessed. The data were entered into Microsoft Excel, and descriptive analysis was performed using the Statistical Package for Social Sciences (SPSS), version 21.Results Among the 79 responses received, 72 (92.4%) students gave a good rating of the process of PBL, indicating a favorable attitude. The participants agreed with the themes based on the influence of discussion, content tested, course objectives, lectures, tutors, and reference literature. Similarly, 63 (81%) students gave a good rating of the tutorials’ performance, suggesting a favorable attitude. They agreed that tutors facilitated active, self-directed, contextual, and collaborative learning.Conclusions This study revealed the positive perceptions and attitudes of medical and dental undergraduate students regarding the PBL process and the role of tutors in PBL. The outcomes of this study have provided a foundation for implementing PBL in Nepal's medical and dental undergraduate curricula.
Prognostic significance of low HER2 expression in gastric cancer: a retrospective, single-center analysis
Authors: Gokon Yusuke , Nakashima Yuka , Ohki Yusuke , Ogino Takahiro , Hatoyama Keiichiro , Shimizu Kenji , Kashiwadate Toshiaki , Katsura Kazunori , Abe Takayuki , Sato Koichiro
Published: February 2024

Introduction: Mutated human epidermal growth factor receptor 2 (HER2) is an oncogene with critical pathogenic roles in breast cancer. HER2-low-positive breast cancer is a recently described subtype. We aimed to explore the clinical and molecular characteristics of gastric cancer with low HER2expression, drawing on recent developments in breast cancer subtypes.
Material and methods: This retrospective study involved 135 patients with HER2-non-amplified gastric cancer treated in Iwate Prefectural Iwai Hospital from 2013 to 2018. HER2 evaluation was performed per the 2013 American Society of Clinical Oncology/College of American Pathologists guidelines, and tumors were classified as HER2-null or low-positive based on immunohistochemistry score 0 or 1+ or 2+ with HER2 negativity in situ hybridization, respectively. Statistical analyses, including Kaplan–Meier analyses and Cox proportional hazards model were conducted.
Results:Low HER2 expression was present in 25% (34/135) of the patients. Clinicopathological characteristics were not significantly different between the HER2-low and null groups. Kaplan–Meier analysis of overall survival was significantly longer in the HER2-low group than in the HER2-null group (P = 0.01). In multivariate Cox regression analysis, HER2-null status was associated with worse survival (hazard ratio 2.92; 95% confidence interval 1.24–6.86; and P = 0.01).
Conclusion: This study highlights the prognostic importance of low HER2 expression in gastric cancer, similar to that observed in HER2-low-positive breast cancer, and suggests reclassification of gastric cancer to improve personalized treatment. Future studies should elucidate the molecular underpinnings of low HER2 expression in gastric cancer to guide novel therapeutic strategies and improve outcomes.
Dynamic change characteristics of wetlands in Hefei and their driving factors along the urban–rural gradient
Authors: Zhang Hui , Li Chuntao , Zhang Yichen , Zhang Lang
Published: February 2024

Context
Wetlands persistently diminish due to their own vulnerability, along with the combined impact of changes in the ecological surroundings and interference from anthropogenic interventions. Comprehending the driving mechanisms of wetland changes is crucial for wetland conservation.
Objectives
This research seeks to analyze the dynamic change characteristics of wetlands in Hefei. The objective is to establish a framework for urban-rural gradient analysis, exploring the impact of ecological surroundings and anthropogenic interventions factors, as well as their interactions, on wetland dynamics across different urban-rural gradient regions.
Methods In this research, an urban-rural gradient was defined utilizing a clustering indicator derived from the composition and configuration of land use. The optimal parameters-based geographical detector (OPGD) performed a quantitative statistical analysis of the driving forces behind wetland changes under different urban–rural gradients.
Results
The results indicate that: (1) From 1990 to 2020, wetland area exhibited an ongoing diminishing tendency. (2) The urban–rural gradient can be classified into four categories: urban, agricultural village, semi-ecological village, and ecological village. (3) The driving factors of wetland changes vary across different types of urban–rural gradient regions. The most significant factors influencing wetland changes in each type of gradient region during different periods are the cropland proportion, impervious surface, OC, silt, and GDP. (4) Interactions among driving factors generally exhibit stronger explanatory power.
Conclusions
The research results reveal the driving mechanisms that underlie wetland dynamics in different urban–rural gradient regions. This information supports the development of more targeted wetland restoration and protection plans, contributing to improved synergy between urban and rural development and ecological conservation efforts.
Experimental and Theoretical Study of Hybrid Dihydrogen Phosphate System: Insights into Bulk Growth, Chemical Etching, Non-Linear Optical Properties, and Antimicrobial Activity
Authors: Rafik Abdellatif , Lakhdar Fatima , Zouihri Hafid , Guedira Taoufiq , Acharjee Nivedita , Islam Mohammad Shahidul , Salah Mohammed , Zeroual Abdellah
Published: February 2024

The controlled slow evaporation process conducted at room temperature has yielded a novel hybrid material designated as (2-hydroxyethyl) trimethylammonium dihydrogen phosphate [2-HDETDHP] (C5H14NO+, H2PO4−), cultivated through the solution growth method. X-ray crystallography analysis indicates that the material adopts a triclinic structure with a filling rate of P\(\stackrel{-}{1}\)and a Z value of 2. This hybrid material exhibits significant absorption characteristics in the middle and far ultraviolet regions, UV-visible spectroscopy revealed that it remained transparent in the visible and near-visible ultraviolet domains. The various vibration modes were examined using FT-IR spectroscopy, and their relationships with the functional groups of the related structure were determined. Two- and three-dimensional fingerprint maps, along with three-dimensional using crystal Structures through Hirshfeld Surface Analysis, elucidate that O•••H and H•••H interactions dominate the structure, constituting the major proportions of 49.40% and 50.40%, respectively. Hirshfeld surfaces were employed to investigate intermolecular hydrogen bonding specifically within single phosphate groups. Fingerprint plots derived from the Hirshfeld surface were utilized to assess the pertinent percentages of hydrogen bonding interactions, with 80.6% of them being attributed to a fragment patch. This discovery holds potential implications for the future design and synthesis of large nonlinear optical (NLO) hybrid crystals.
Improved YOLOv7 Algorithm for Floating Waste Detection Based on GFPN and Long-Range Attention Mechanism
Authors: Peng Cheng , He Bing , Xi Wenqiang , Lin Guancheng
Published: February 2024

Floating wastes in rivers possess characteristics including small scale, low pixel density and complex backgrounds, which makes it prone to false and missed detection during image analysis, thus resulting in a degradation of detection performance. In order to tackle these challenges, a floating waste detection algorithm based on YOLOv7 is proposed, which combines the improved GFPN and long-range attention mechanism. Firstly, we import the improved GFPN to replace the Neck of YOLOv7, thus providing more effective information transmission that can scale into deeper networks. Secondly, the convolution-based and hardware-friendly long-range attention mechanism is introduced, allowing the algorithm to rapidly generate attention map with a global receptive field. Finally, the algorithm adopts the WiseIoU optimization loss function to achieve adaptive gradient gain allocation and alleviate the negative impact of low-quality samples on the gradient. The simulation results reveal that the proposed algorithm has achieved a favorable average accuracy of 86.3\% in real-time scene detection tasks. This marks a significant enhancement of 6.3\% compared to the baseline, indicating the algorithm's good performance for floating waste detection.
Comparative Analysis of Symmetry Parameters in the E2 inner core of the pyruvate dehydrogenase complex
Authors: Kim Han-ul , Jeong Myeong Seon , An Mi Young , Park Yoon Ho , Park Sun Hee , Chung Sang J. , Yi Yoon-Sun , Jun Sangmi , Jung Hyun Suk
Published: February 2024

Recent advancements in cryo-electron microscopy (cryo-EM) have greatly facilitated the high-resolution structural determination of macromolecular complexes in their native states. The resultant deeper understanding of the structural mechanisms of protein complexes has improved our accessibility, not only to the field of structural biology but also to various biological phenomena. The structural analysis of proteins using cryo-EM, particularly single-particle analysis (SPA), entails the reconstruction of protein maps, which relies on the symmetry parameters of these proteins to obtain a more accurate map with the aid of image processing. In this paper, we present in the case of strong icosahedral symmetric complex, dihydrolipoyl acetyltransferase (E2) inner core complex of the pyruvate dehydrogenase complex (PDC) and obtain the reconstruction of identical 3D maps using five different symmetry parameters, including C1 without symmetric restraints to examine the impact of symmetry parameters for detailed structural analysis with a higher resolution. The results shows that the reconstructions using inappropriate symmetric parameters produce structurally identical 3D models even at the near-atomic level. Our findings convey a crucial message that should not be disregarded by researchers delving into SPA using relatively user-friendly and convenient image processing software for improved 3D model.
HDZ-740, a Potent FLT3 Inhibitor to Overcome FLT3 Mutations of Acute Myeloid Leukemia
Authors: Qiu Peiju , Yang Ting , Bi Shijie , Gao Yan , Wang Liping , Chu Yanyan , Yu Rilei , Yang Jinbo , Zhu Weiming , Chen Linmeng
Published: February 2024

Acute myeloid leukemia (AML) is a life-threatening cancer characterized by a five-year survival rate of less than 30%. A pivotal target for AML therapy is an activating mutation in Fms-like tyrosine kinase 3 (FLT3), known as FLT3-ITD, which has been identified as a critical factor in disease progression. Despite the clinical development of three FLT3 inhibitors, resistance to these drugs often emerges, leading to relapse in patients. In this context, we have developed a novel marine-derived compound, namely HDZ-740, which has demonstrated a specific ability to inhibit the proliferation of AML cells carrying the FLT3-ITD mutation. Furthermore, HDZ-740 markedly impeded the growth of BaF3 cells expressing FLT3-ITD-TKD mutations, including D835V, D835Y, Y842C, Y842H, F691L, N676K, as well as AML blasts from patients with FLT3-ITD mutations. HDZ-740 has also shown inhibitory effects in environments conducive to drug resistance, such as under the protection of stromal cells. In vivo, HDZ-740 effectively hindered the expansion of AML cells with the FLT3-ITD mutation. Collectively, these findings underscore the potential of HDZ-740 as an effective therapeutic agent for treating AML patients harboring diverse FLT3-ITD and FLT3-TKD mutations and highlight its capability to circumvent mechanisms of drug resistance.
The Effects of Microburst Varying Loads on Aircraft Using a Multi-Point Approach
Authors: Pourmoradi Ali , Sabzehparvar Mehdi
Published: February 2024

Microburst is an atmospheric phenomenon that poses a dangerous and unavoidable threat to flying aircraft during takeoff and landing. The dynamic response of the aircraft encountered to the microburst was studied. Research on the interaction between microburst and aircraft motion is needed to assess the effects of aerodynamic forces and momentum. Unlike recent studies using conventional integrated aerodynamic models, the multi-point loading approach allows microburst wind loading at any point on the wing and tail combination. In this method, a general reconstruction of aerodynamic forces and moments is calculated by microburst integration with different non-uniformly distributed loads functions on each surface of the aircraft. This algorithm solves the nonlinear equations of motion of a plane with six degrees of freedom and updates the plane's dynamic parameters as input to calculate time- and space-varying microburst effects for each element. The computational complexity of this method is therefore much reduced compared to CFD analysis and at the same time the details of the flight characteristics are taken into account without simplification in the simulation, which takes about 90 seconds of simulation time. We simulate and compare the results of a new and existing micro-race modeling approach. Comparing the two models shows significant differences in flight conditions such as aircraft flight path, angle of attack and angular velocity.
Effects of Lupeol On Experimental Testicular Ischemia/Reperfusion Damage in Rats
Authors: Azzam Abdurrahman , Karabulut Ramazan , Kaya Cem , Eryilmaz Sibel , Kapisiz Alparslan , Turkyilmaz Zafer , Inan Mehmet Arda , Aydin Gizem Yaz , Sonmez Kaan
Published: February 2024

Objective Infertility and organ loss are possible outcomes of testicular torsion, a urological emergency. We sought to demonstrate the impact of lupeol on testicular ischemia reperfusion damage in this investigation.Methods 30 adult male Spraque Dawley rats were randomized and divided as Control(C), Lupeol(L), Ischemia(I), Treatment 1(T1) and Treatment 2(T2) groups. In the study groups, detorsion was applied to the left testicles by creating 720 degree testicular torsion for 2 hours. While 100 mg/kg Lupeol was injected intraperitoneally in the T1 and T2 groups 30 min. before and immediately after testicular detorsion. At the sixth hour, samples of blood and testicular tissue were obtained from every rat. Measurements were taken of serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) tissue glutathione (GSH), malondialdehyde (MDA), and caspase 3. Histopathological analysis was used to evaluate the Johnsen Tubular Biopsy Score (JTBS).Results It was observed that Caspase 3, MDA, IL-6 and TNF-ɑ values, which increased in Group I compared to the Group C, decreased more significantly in both treatment groups and especially in the GroupT1 group (p = 0.001, only p = 0.768 for TNF-ɑ). GSH levels was decreased in Group I, increased more significantly in both treatment groups and especially in the GroupT1 group. JTBS improvement was observed in both treatment groups (p = 0.001).Conclusion In this study, where Lupeol was used for the first time in an experimental testicular torsion model, its antioxidant, anti-inflammatory and anti-apoptotic effects, as well as its histopathological damage-reducing and protective effects, were demonstrated.
Blow up Analysis of Constraint Minimizers for a Class of Elliptic Equations with Bi-nonlocal Terms
Authors: Zhu Xincai , Zhu Yajie
Published: February 2024

This paper is devoted to studying a class of elliptic equations with bi-nonlocal terms. Using the methods of constrained variation and energy estimation, we analyze the existence, non-existence and blow-up behavior of constraint minimizers for the related minimization problem. Our work extend and enrich the results of [7,40], which mainly involve bi-nonlocal problems.
2020 MSC: 32J20; 35J60; 35Q40; 46N50
Exploring stress corrosion cracking in 2205 duplex stainless steel across varied stress thresholds
Authors: Zhao Shuai , Wen Shaomu , Guo Xiaoxiong , Qin Lin , Lin Dong , Liao Kexi
Published: February 2024

Reboilers are pivotal in the process of condensate oil stabilization, playing a significant role in reducing the vapor pressure to ensure product stability. The operational milieu of reboiler tube bundles is marked by extremities—high temperatures, elevated salinity, and the presence of dissolved oxygen—rendering them vulnerable to stress corrosion cracking. Such conditions can precipitate untimely degradation and disrupt production schedules. Addressing this, our research employed electrochemical noise measurement techniques to perform a statistical examination of the morphological characteristics of noise peaks, alongside time and frequency domain analyses for 2205 Duplex Stainless Steel(DSS), under an array of stress levels, ranging from 60%σs to 90%σs. Complementary Scanning Electron Microscopy analysis was utilized to discern microscopic changes pre- and post-corrosion exposure. Findings have demonstrated pronounced localized corrosion at each measured stress level, with localized corrosion index values spanning from 0.4290 to 0.9993. The presence of chloride ions was found to penetrate the passive film, selectively targeting the ferrite phase for pitting. Furthermore, the confluence of mechanical stress and corrosive elements facilitated the nucleation of crack tips, with oxygen and chloride ions synergistically escalating crack propagation. Our study concludes that the SCC of 2205 DSS follows a dual path: anodic dissolution alongside hydrogen embrittlement, culminating in surface pitting and intergranular cracking.
Investigation of the heat resistance of a metal-glass composite material based on iron
Authors: Getmanovskiy Yuriy , Maltsev Ilya
Published: February 2024

The article presents a study aimed at obtaining a composite antifriction material. The structure and properties of a metal-glass material based on iron, represented by VK-1 powder, were researched. The relationship between the content of the reinforcing glass filler, represented by the shards of container glass, and the heat resistance of the resulting composite was revealed. It was revealed that with an increase in the content of glass filler up to 15% of the volume, the heat resistance increases.
Potential Assessment of Chrysanthemum Cultivars as Source of Natural antioxidants and Bioactive Compounds
Authors: Patil Savita A. , Kulkarni Asmita J. , Jadhav Pritam R. , Yadav Rahul S. , Pagariya Madhuri C. , Saha Tarak Nath , Shabeer TP Ahammed , Sharma Ajay K. , Prasad K.V. , Kawar Prashant G.
Published: February 2024

Chrysanthemum blossoms, renowned for their aesthetic appeal, have gained recognition as potential contributors to nutraceuticals, cosmeceuticals, and pharmaceuticals, thereby impacting human health. Phytochemical composition and antioxidative properties of 22 distinct Indian chrysanthemum cultivars was studied. The cultivars viz., Bidhan Protima, Mauve Sarah, Silk Brocate, Diamond Jubilee, and Mahatma Gandhi displayed remarkable levels of phenolic compounds, tannins, saponins, and carotenoids, emphasizing their superior antioxidant capacity. This study also presents the first quantitative determination of total saponin content in Chrysanthemum morifolium. Hierarchical analysis categorized cultivars into three groups based on their phytochemical profiles. Correlation analysis underscored the importance of anthocyanins and phenolic compounds in antioxidative attributes. Additionally, variations in carotenoid content unveiled astaxanthin, zeaxanthin, mutatochrome, canthaxanthin, neoxanthin, violaxanthin, and auroxanthin as potential biomarkers in differentiating cultivars. The research elucidates the rich phytochemical diversity of Indian chrysanthemum cultivars, positioning them as invaluable resources for nutraceuticals and pharmaceuticals, with potential benefits for human well-being.
Impact of the Behavior Modulated LEACH System
Authors: Korteby Amine , Gal Zoltan
Published: February 2024

Wireless Sensor Networks (WSNs) have made significant strides in recent years owing to their growth in terms of equipment and cost reduction. Several services have been designed, based on the application and network architecture. The LEACH (Low Energy Adaptive Clustering Hierarchy) mechanism is one of the most considerable energy protecting solutions in WSN environments. This hierarchical protocol aggregates and forwards data from cluster members to a fixed Sink node using the cluster head feature of the nodes. We developed a new set of routing mechanisms called CB-LEACH by introducing movement possibility to the Sink node and balancing the cluster head election decision taking into consideration not just the distances between the nodes but the residual energy of the potential cluster head candidates, as well. In this paper, we modulate the balance factor of the cluster head election to conform to different rules and we analyzed the behaviour of the new system and its most important features.
Irrigation Water productivity in Rice Crop through Alternate Wetting and Drying method
Authors: Gautam Anand , Kendra Krishi Vigyan
Published: February 2024

The demonstrations on alternate wetting and drying (AWD) in rice crop were conducted by KVK Ferozepur, Punjab during Kharif 2019-21 at 25 locations in 5villages of district. The selected study locale was characterized by well drained sandy loam with medium soil fertility status. The three plots of 0.4 ha size each was selected for the two treatments i.e. alternate wetting and drying and continuous submergence (farmer practice) at each of 25 locations. The rice grain yields increased by 1.18 per cent under AWD compared to the continuous submergence (71.4 q/ha). The irrigation water productivity (IWP) was higher by 18.36 per cent under AWD compared to that in continuous submergence. Ricecrop under AWD required 30 cm smaller amount of irrigation water during its whole growing season compared to the continuous submergence. The AWD technique holds great promise as water-saving technology that can help to address water scarcity in the rice growing areas of food basket bowl of India. Therefore, the AWD method could enhance yield and save irrigation water by 18–20 percent in rice crop.
Nonlinear relationship between platelet count and 30-day in-hospital mortality in ICU acute respiratory failure patients: a multicenter retrospective cohort study
Authors: Zhou Pan , Guo Qin-qin , Wang Fang-xi , Zhou Li , Hu Hao-fei , Deng Zhe
Published: February 2024

Background
Limited evidence exists regarding the link between platelet count and 30-day in-hospital mortality in acute respiratory failure (ARF) patients. Thus, this study aims to investigate this association among ICU patients experiencing acute respiratory failure.
Methods
We conducted a retrospective cohort study across multiple centers, utilizing data from the US eICU-CRD v2.0 database covering 22,262 patients with ARF in the ICU from 2014 to 2015. Our aim was to investigate the correlation between platelet count and 30-day in-hospital mortality using binary logistic regression, subgroup analyses, and smooth curve fitting.
Results
The 30-day in-hospital mortality rate was 19.73% (4,393 out of 22,262), with a median platelet count of 213×109/L. After adjusting for covariates, our analysis revealed an inverse association between platelet count and 30-day in-hospital mortality (OR = 0.99, 95% CI: 0.99, 0.99). Subgroup analyses supported the robustness of these findings. Furthermore, a nonlinear relationship was identified between platelet count and 30-day in-hospital mortality, with the inflection point at 120×109/L. Below the inflection point, the effect size (OR) was 0.89 (0.87, 0.91), indicating a significant association. However, beyond this point, the relationship was not statistically significant.
Conclusion
This study establishes a clear negative association between platelet count and 30-day in-hospital mortality among ICU patients with ARF. Furthermore, we identified a nonlinear relationship with a saturation effect, indicating that maintaining the platelet count around 120×109/L can reduce 30-day in-hospital mortality in this patient group.
Ameliorative role of β-Caryophyllene on antioxidant biomarkers in Paroxetine induced erectile dysfunctional rats
Authors: Olopade Elijah Oluwatosin , Adefegha Stephen Adeniyi , Oboh Ganiyu , Adepoju Ayodeji Emmanuel , Fakayode Aderonke Elizabeth , Alao Jude Oluwapelumi
Published: February 2024

Erectile dysfunction is a leading cause of male infertility linked to oxidative stress. This study aimed to assess B-Caryophyllene (BCP) as an antioxidant on penile tissue in Paroxetine-induced rats. In vitro tests evaluated BCP's antioxidant properties, including ferric reduction, DPPH, ABTS, and hydroxyl radical scavenging, plus TBARs assays. Forty-five rats were divided into nine groups: Normal control (NC), BCP (10 mg/kg), BCP (20 mg/kg), Sildenafil citrate (SC) (20mg/kg), BCP + SC (20 mg/kg), Paroxetine (PD) (20 mg/kg), PD + BCP (10mg/kg), PD + BCP (20mg/kg), and PD + SC (20 mg/kg). PD was orally administered for seven days. BCP and SC treatments occurred from day 8 to 14. Enzyme activities (S.O.D., Catalase, G.S.T., and GPx) and TBARS were measured spectrophotometrically. PD caused erectile dysfunction, reducing mount latency (ML) and intromission latency (I.L.). BCP concentration-dependently enhanced reducing power, ABTS, OH scavenging, and % DPPH inhibition, significantly lowering %TBARS compared to sildenafil citrate. IC50 values for OH radical, DPPH, and Iron (II) ion chelation were 10.98 µg/mL, 59.14 µg/mL, and 17.36 µg/mL. In vivo, BCP significantly (p < 0.001) increased S.O.D., Catalase, and GPx activities. G.S.T. activity significantly (p < 0.01) increased with BCP (20 mg/kg). BCP (20 mg/kg) significantly (p < 0.001) lowered TBARS more effectively than SC. BCP, especially at 20 mg/kg, displayed potent antioxidative effects on penile tissue in Paroxetine-induced rats.
Analisis Pencapaian Implementasi Permakultur di SMK Suwakul Ungaran Menggunakan Balanced Scorecard
Authors: Handayani Susana Ayu , Wiyatiningsih
Published: February 2024

Title: Analysis of Achievement for Permaculture Implementation at Suwakul Vocational High School Ungaran Using Balanced Scorecard

The agricultural vocational school program hopes to increase human resources capable of cultivating land, managing horticultural crops, and producing agricultural products. Suwakul Ungaran Vocational School is one of the vocational schools in Semarang Regency that applies permaculture in its learning process. The permaculture principles applied at this school are capturing and storing energy, getting harvests, using and respecting resources, zero waste, and respecting diversity. Based on this background, this research focuses on learning outcomes through implementing permaculture with a sustainable agricultural system that includes the development of land processing based on natural ecosystems. The research aims to determine the ability of students at school to produce food and horticultural crops. This research applies a qualitative descriptive method to describe the results of permaculture implementation using Balanced Scorecard analysis, an evaluation strategy with four perspectives in improving an organization's goals. The research results show that learning through the implementation of permaculture at this Vocational School can improve students' abilities at school, as seen from fulfilling the perspective of the Balanced Scorecard. The study's results will be helpful for schools as a learning tool to improve students' abilities in producing agricultural products through the implementation of permaculture.
La interculturalidad como posibilidad para las pedagogías en América Latina
Authors: Saldaña Duque Reina
Published: February 2024

El artículo propone entender el lugar de las pedagogías en América Latina desde la interculturalidad, considerando los procesos educativos de algunos movimientos sociales a partir de cuatro momentos. Primero, los rasgos de la perspectiva intercultural en clave de la configuración de lo humano; segundo, el reconocimiento de las epistemes desde la interculturalidad; tercero, la emergencia de las pedagogías latinoamericanas a partir de las sociedades en movimiento; y cuarto, la comprensión de algunas consecuencias antropológicas y epistémicas que se desprenden de los movimientos analizados para restablecer las pedagogías latinoamericanas. El enfoque de la hermenéutica intercultural se diferencia por el valor antropológico, epistémico y ontológico, orientado hacia el reconocimiento de los logos que emergen en las culturas, enfatizando en significados y prácticas vividas. El método de revisión documental en fuentes de carácter teórico-académico y legal-normativa busca observar organizaciones, posturas políticas, sujetos y contextos. En las conclusiones, se presenta la tesis de la interculturalidad como condición de posibilidad para las pedagogías en América Latina, con base en un accionar que se mueve en los ritmos de las comunidades, donde se suscitan pedagogías desde las márgenes de las sociedades en movimiento en torno a dos miradas: la cultura política y la cultura vivida.
Tazkiyat Al-Nafs as Resilience Strategy to Deal with the Post-Pandemic Recession among Micro, Small, and Medium Enterprises (MSMEs) Actors
Authors: Adlina Atika Ulfia , Rahman Zaizul Abd , Sakdullah Muhammad , Aisyah Dewi , Al Amin Ferizka Rizky
Published: February 2024

This paper examines how resilience religiosity using the tazkiyat al-nafs technique is carried out by economic actors from the elements of Micro, Small, and Medium Enterprises (MSMEs) facing a post-pandemic recession. In-depth interviews were conducted with 27 MSME actors. The findings reveal that the pattern of tazkiyat al-nafs as a religiosity resilience used by economic actors from elements of Micro, Small, and Medium Enterprises (MSMEs) in facing the post-pandemic recession has succeeded in making it easier for them to adapt and create innovation and creativity to overcome post-pandemic recession conditions. On the other hand, MSME actors who are not in the tazkiyat al-nafs pattern have difficulty adjusting themselves in times of crisis.Contribution: The contribution of this paper is to provide a new understanding that maqāmāt can be used as a self-management technique when facing difficult times. In addition, maqāmāt can also be applied by ordinary people from Sufism teachings. Maqāmāt is a new way of religious resilience.