bluuebunny/crossref_metadata_2025 huggingface dataset:
Contrast-enhanced ultrasound of adrenal hemorrhage: a helpful problem solving tool
Authors: Piskunowicz Maciej , Stefanowicz Joanna , Batko Tomasz , Hwang Misun , Świętoń Dominik , Szarmach Arkadiusz , Back Susan , Kosiak Wojciech
Published: March 2022

Aims: A focal lesion in the region of the adrenal gland in a newborn often requires further assessment. Ultrasound (US) is the initial imaging method of choice in young children as it does not use radiation or require sedation and it has excellent spatial resolution. In this case series, we present contrast-enhanced ultrasound (CEUS) as a problem-solving tool in the evaluation of neonatal adrenal lesions.Material and methods: The imaging and medical records of five patients with adrenal lesions were retrospectively reviewed. All patients underwent US as an initial examination and all had US follow-up. Additionally, two patients had MRI examinations. CEUS was performed in all patients as a follow up examination. The enhancement characteristics of the adrenal masses on CEUS were analyzed with the use of VueBox software. In addition, qualitative analysis of the cine loops for the presence of vascularization within the lesions was performed by consensus between two radiologists.Results: The presence of an adrenal hematoma was correctly detected and characterized by CEUS in all five cases using VueBox perfusion analysis. Adrenal hematomas had no internal perfusion and flat time intensity curves.Conclusion: The quantitative and qualitative CEUS assessment of the mass can distinguish hemorrhage from a malignant lesion. Based on our findings, CEUS could serve as an alternative diagnostic tool to magnetic resonance imaging in the diagnosis of slowly resolving NAH lesions.
An unusual complication of myocardial infarction
Authors: Mada Cristina , Mada Razvan Olimpiu , Stef Adrian , Molnar Adrian , Rosianu Horia Stefan
Published: March 2022

Despite medical and interventional advances, the mechanical complications of acute myocardial infarction are associated with high mortality. Timely surgical therapy requires a prompt and accurate diagnosis. Multimodality imaging has become the standard of care in modern cardiology. Despite the widespread use and cost-effectiveness of cardiac ultrasound in the acute setting, the method is highly user-dependent. In complex cases a second imaging technique is often required. The case presents the key role of multimodal imaging in the evaluation of a patient with a very rare complication of an acute myocardial infarction, a pseudoaneurysm of the interventricular septum respectively. In addition to confirming the diagnosis assumed by echocardiography, cardiac computed tomography provides additional structural and functional information essential to proper management.
The added value of CEUS and ultrasound-guided biopsy in diagnosing an aggressive desmoplastic small round cell tumour of peritoneum in a young male. A case report
Authors: Sparchez Mihaela , Mocan Tudor , Caraiani Cosmin , Rusu Ioana , Sparchez Zeno Adrian
Published: March 2022

Desmoplastic small round cell tumour (DSRCT) is a rare and highly aggressive mesenchymal neoplasm with poor prognosis that develops in male adolescents and young adults. We report the case of a 32-year-old male admitted with abdominal distension and ascites. An ultrasonography (US) scan showed multiple peritoneal masses with large ascites. The dominant mass had a hypervascular homogenous aspect at contrast-enhanced ultrasound with wash-out in the venous phase. Thoracoabdominal CT, performed for staging the disease, confirmed the US aspect. The US-guided percutaneous biopsy revealed DSRCT of the peritoneum. Chemotherapy was then started with minimal clinical improvement, increase in tumoral burden and death after three months. US and US-guided biopsy played an essential role in diagnosing this case. The aggressive course of the disease and seeding at paracentesis sites are the particularities of the presented case.
Food and foodways narratives: recipes of social memory
Authors:   Universidade Federal do Estado do Rio de Janeiro (Unirio), Amon Denise , Menasche Renata
Published: March 2022

In this paper, the authors address the cultural dimension of food brought out through social action. Building their reflection on experiences lived by a Sephardi Jewish family established in Brazil and reviewing recipes of some daily dishes, the authors discuss how a community may manifest emotions, systems of relevance, meanings, social relationships and collective identity through its food. They analyze the recipes and suggest that food and foodways can constitute themselves as narrative of a community’s social memory arguing that these food narratives also build communities. In this paper, a personal and singular story is told, yet it introduces many others. As proposed by anthropology, it shows that a specific research territory can create questionings and open the way for more comprehensive analyses and interpretations. This pathway implies framing by the contextual and socio-historical influences, different from what is usual in other social sciences, where the individual instance is chosen because of its representativeness according to pre-existing criteria, serving as an illustration of analytical categories established at the formulation of an initial problem. The story told is not detached from a collective cultural symbolic system; rather, it is embedded in the social fabric of the symbolic products built and negotiated in culture and social milieus.
Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones
Authors: Basarab Gregory S. , Ghorpade Sandeep , Gibhard Liezl , Mueller Rudolf , Njoroge Mathew , Peton Nashied , Govender Preshendren , Massoudi Lisa M. , Robertson Gregory Thomas , Lenaerts Anne J. , Boshoff Helena Ingrid , Joerss Douglas , Parish Tanya , Durand-Reville Thomas F. , Perros Manos , Singh Vinayak , Chibale Kelly
Published: March 2022

Described here is a series of spiropyrimidinetrione (SPT) compounds with activity against
Mycobacterium tuberculosis
through inhibition of DNA gyrase. The SPT class operates via a novel mode of inhibition, which involves Mg
2+
-independent stabilization of the DNA cleavage complex with DNA gyrase and is thereby not cross-resistant with other DNA gyrase-inhibiting antibacterials, including fluoroquinolones.
Kinetic Equations of Physicochemical Processes with Allowance for Multi-Particle Effects in the Lattice Gas Model
Authors: Tovbin Yu. K.
Published: March 2022

A way of deriving kinetic equations of physicochemical processes in dense phases is developed on the basis of the discrete–continuous description of the spatial distribution of components in the lattice gas model (LGM), with allowance for multi-particle effects. The emergence of multi-particle effects is associated with the simultaneous influence of all neighbors on the rate of the elementary stage with the participation of a given particle. They include multi-particle potentials of interaction, including quantum–chemical energy calculations, the effect the configurations of neighboring molecules have on the internal motion of the central particle, and the effects of the indirect correlation of interacting particles that occurs for any potential of pair interaction, assuming the internal motions of particles do not depend on the local configurations of neighbors. Multi-particle effects take models beyond the quasi-chemical approximation, which reflects direct correlations of interacting particles through pair distribution functions, and require the use of correlation functions for a larger number of particles in describing their kinetics. The rates of elementary one- and two-node stages are calculated within the theory of absolute rates of reactions in non-ideal reaction systems. Ways of calculating approximate rates of the elementary stages of mono- and bimolecular processes are discussed, along with the possibilities of generalizing the derived equations.
Effects of FeNiN phases on the corrosion behavior in 2205 duplex steels
Authors: Li Taotao , Ma Shijie , Feng Shixin , Ren Ruxin , Zhang Li , Lu Huihu , Li Guoping , Zhang Yaohui , Fan Wei , Liu Chengzhi , Zhou Diaoyu
Published: March 2022

Corrosion resistance is of practical importance for the application of 2205 duplex steels in chemical industries. For taking an insight into pitting corrosion behavior, electrolysis was employed to distinguish the 2205 duplex steel samples. In the following, X-ray diffraction, scanning electron microscopy and electron backscattering diffraction are used to characterize the regions with superior and inferior corrosion performance, thus constructing the relationship between the microstructure and their corrosion behavior.
Study of weld formation characteristics in laser-arc hybrid welding
Authors: Sun Hongwei , Yang Zhidong , Fang Chenfu , Chen Yuntao , Zhang Yongshun , Shi Mingxiao
Published: March 2022

The laser-arc hybrid welding was carried out on the marine-use steel, and the effects of primary parameters on weld behavior were investigated. The results show that the weld penetration increased gradually with the increase of laser power. Meanwhile, superior weld formation, penetration and reinforcement were achieved when laser and wire distance was 2 mm. The weld width, penetration and reinforcement were increased with the increase of current, while they were decreased with the increase of welding speed. The influence of laser power on the generated microstructure was analyzed by the observation in junction of weld and heat affected zone (HAZ). The microstructure of HAZ coarsened with the increase of laser power, which is consistent with the hardness distribution trend in HAZ.
Influence of SiC nanowires on the microstructures and properties of Ag–Cu–Ti filler metals and brazed joints
Authors: Zhang Liang , Long Wei-Min , Jiang Nan , Xu Kai-Kai , Li Mu-Lan , Li Zhi-Hao
Published: March 2022

Ag–26.7Cu–4.5Ti filler metals with different contents of SiC nanowires were prepared to analyze the effect of SiC nanowires on the microstructures, melting temperature, wettability, shear strength and fracture morphology of brazed joints. The results indicate that a small amount of SiC nanowires ([Formula: see text]0.1%) can refine the matrix microstructure and reduce the Cu–Ti intermetallic compounds, which can induce the increase of shear strength of brazed joints with 46.7% maximum amplitude, the ductile pattern is the main fracture mode for Ag–Cu–Ti–1.0 SiC brazed joints. Moreover, the SiC nanowires can improve the spreading are of Ag–Cu–Ti filler metals on steel substrate with a 9.4% increase amplitude, when the content of SiC nanowires is more than 0.1%, the wettability can be reduced obviously. The addition of SiC nanowires can show little effect on the melting temperature, which results in the same brazing temperature for Ag–Cu–Ti–[Formula: see text]SiC filler metals. With the optimization content of SiC nanowires, the optimal content of SiC is 0.05–0.1%, excessive SiC addition with agglomeration can decrease the wettability and shear strength.
Local and 2-local derivations on octonion algebras
Authors: Ayupov Shavkat , Kudaybergenov Karimbergen , Allambergenov Allayar
Published: March 2022

This paper is devoted to study of local and 2-local derivations on octonion algebras. We shall give a general form of local derivations on the real octonion algebra [Formula: see text]. This description implies that the space of all local derivations on [Formula: see text] when equipped with Lie bracket is isomorphic to the Lie algebra [Formula: see text] of all real skew-symmetric [Formula: see text]-matrices. We also consider [Formula: see text]-local derivations on an octonion algebra [Formula: see text] over an algebraically closed field [Formula: see text] of characteristic zero and prove that every [Formula: see text]-local derivation on [Formula: see text] is a derivation. Further, we apply these results to similar problems for the simple seven-dimensional Malcev algebra. As a corollary, we obtain that the real octonion algebra [Formula: see text] and Malcev algebra [Formula: see text] are simple non-associative algebras which admit pure local derivations, that is, local derivations which are not derivation.
Trace elements in pyrite from five different gold ore deposit classes: a review and meta-analysis
Authors: Babedi Lebogang , von der Heyden Bjorn P. , Tadie Margreth , Mayne Matthew
Published: March 2022

Scientific studies that use pyrite trace element signatures to facilitate interpretations of the geological history of hydrothermal gold deposits are becoming more common. Given this rise in popularity in pyrite trace element chemistry studies, a review of trace element incorporation in pyrite from various gold deposit classes is highly timely. We provide a global compilation of over 20 000 chemical data points resulting from over 5520 spot measurements of pyrites from five separate ore deposit classes, each of which is known to have high gold concentrations. The ore deposit classes considered here include orogenic gold deposits, Carlin-type gold deposits, high- and low-sulfidation gold deposits, and Au-bearing porphyry systems, whereas the pyrite minor- and trace elements that we consider include Au, As, Bi, Co, Cu, Ni, Pb, Sb, Se, Te, Tl and Zn. Meta-analyses of these data suggest that, on a global scale, both existing pyrite trace element chemistry discrimination tools and the newly-established principal component analysis (PCA) approach have a relatively low efficacy in correctly predicting the metallogenic setting in which the pyrite formed. At a deposit scale, however, pyrite trace element chemistry continues to be a useful tool for understanding Au mineralizing processes, especially when coupled with additional analytical techniques or lines of geological evidence. Further meta-analysis of the data tentatively suggests the solubility limits for the various trace elements in pyrite mineral structure and reveals that the correlations between temperature and trace element incorporation (i.e. pyrite geothermometry) are complex. The study highlights that pyrite, by virtue of its mineralogy and propensity for element substitutions, remains an important repository of chemical information related to the evolution of hydrothermal gold mineralizing systems. In as much as this repository is now readily accessed utilizing modern analytical techniques (e.g. routine LA-ICP-MS mapping of trace element distributions at ppb concentrations; mapping element distributions at the nanoscale using atom probe tomography), its full value will only be realized through continued study into the kinetics and mechanisms of trace element incorporation into pyrite structure at conditions relevant to ore-forming processes.
Multi-label Deep Convolutional Transform Learning for Non-intrusive Load Monitoring
Authors: Singh Shikha , Chouzenoux Emilie , Chierchia Giovanni , Majumdar Angshul
Published: March 2022

The objective of this letter is to propose a novel computational method to learn the state of an appliance (ON / OFF) given the aggregate power consumption recorded by the smart-meter. We formulate a multi-label classification problem where the classes correspond to the appliances. The proposed approach is based on our recently introduced framework of convolutional transform learning. We propose a deep supervised version of it relying on an original multi-label cost. Comparisons with state-of-the-art techniques show that our proposed method improves over the benchmarks on popular non-intrusive load monitoring datasets.
Online Scalable Streaming Feature Selection via Dynamic Decision
Authors: Zhou Peng , Zhao Shu , Yan Yuanting , Wu Xindong
Published: March 2022

Feature selection is one of the core concepts in machine learning, which hugely impacts the model’s performance. For some real-world applications, features may exist in a stream mode that arrives one by one over time, while we cannot know the exact number of features before learning. Online streaming feature selection aims at selecting optimal stream features at each timestamp on the fly. Without the global information of the entire feature space, most of the existing methods select stream features in terms of individual feature information or the comparison of features in pairs. This article proposes a new online scalable streaming feature selection framework from the dynamic decision perspective that is scalable on running time and selected features by dynamic threshold adjustment. Regarding the philosophy of “Thinking-in-Threes”, we classify each new arrival feature as selecting, discarding, or delaying, aiming at minimizing the overall decision risks. With the dynamic updating of global statistical information, we add the selecting features into the candidate feature subset, ignore the discarding features, cache the delaying features into the undetermined feature subset, and wait for more information. Meanwhile, we perform the redundancy analysis for the candidate features and uncertainty analysis for the undetermined features. Extensive experiments on eleven real-world datasets demonstrate the efficiency and scalability of our new framework compared with state-of-the-art algorithms.
Microbial metabolites: cause or consequence in gastrointestinal disease?
Authors: Fobofou Serge Alain , Savidge Tor
Published: March 2022

Systems biology studies have established that changes in gastrointestinal microbiome composition and function can adversely impact host physiology. Notable diseases synonymously associated with dysbiosis include inflammatory bowel diseases, cancer, metabolic disorders, and opportunistic and recurrent pathogen infections. However, there is a scarcity of mechanistic data that advances our understanding of taxonomic correlations with pathophysiological host-microbiome interactions. Generally, to survive a hostile gut environment, microbes are highly metabolically active and produce trans-kingdom signaling molecules to interact with competing microorganisms and the host. These specialized metabolites likely play important homeostatic roles, and identifying disease-specific taxa and their effector pathways can provide better strategies for diagnosis, treatment, and prevention, as well as the discovery of innovative therapeutics. The signaling role of microbial biotransformation products such as bile acids, short-chain fatty acids, polysaccharides, and dietary tryptophan is increasingly recognized, but little is known about the identity and function of metabolites that are synthesized by microbial biosynthetic gene clusters, including ribosomally synthesized and posttranslationally modified peptides (RiPPs), nonribosomal peptides (NRPs), polyketides (PKs), PK-NRP hybrids, and terpenes. Here we consider how bioactive natural products directly encoded by the human microbiome can contribute to the pathophysiology of gastrointestinal disease, cancer, autoimmune, antimicrobial-resistant bacterial and viral infections (including COVID-19). We also present strategies used to discover these compounds and the biological activities they exhibit, with consideration of therapeutic interventions that could emerge from understanding molecular causation in gut microbiome research.
Sirtuin deficiency and the adverse effects of fructose and uric acid synthesis
Authors: Rodriguez-Iturbe Bernardo , Johnson Richard J. , Lanaspa Miguel A. , Nakagawa Takahiko , Garcia-Arroyo Fernando E. , Sánchez-Lozada Laura G.
Published: March 2022

Fructose metabolism and hyperuricemia have been shown to drive insulin resistance, metabolic syndrome, hepatic steatosis, hypertension, inflammation, and innate immune reactivity in experimental studies. We suggest that these adverse effects are at least in part the result of suppressed activity of sirtuins, particularly Sirtuin1. Deficiency of sirtuin deacetylations is a consequence of reduced bioavailability of its cofactor nicotinamide adenine dinucleotide (NAD+). Uric acid-induced inflammation and oxidative stress consume NAD+ and activation of the polyol pathway of fructose and uric acid synthesis also reduces the NAD+-to-NADH ratio. Variability in the compensatory regeneration of NAD+ could result in variable recovery of sirtuin activity that may explain the inconsistent benefits of treatments directed to reduce uric acid in clinical trials. Here, we review the pathogenesis of the metabolic dysregulation driven by hyperuricemia and their potential relationship with sirtuin deficiency. In addition, we discuss therapeutic options directed to increase NAD+ and sirtuins activity that may improve the adverse effects resulting from fructose and uric acid synthesis.
Research on Automatic Error Correction Method in English Writing Based on Deep Neural Network
Authors: Cheng Lanzhi , Ben Peiyun , Qiao Yuchen
Published: March 2022

As one of the most widely used languages in the world, English plays a vital role in the communication between China and the world. However, grammar learning in English is a difficult and long process for English learners. Especially in English writing, English learners will inevitably make various grammatical writing errors. Therefore, it is extremely important to develop a model for correcting various writing errors in English writing. This can not only be used for automatic inspection and proofreading of English texts but also enable students to achieve the purpose of autonomous practice. This paper constructs an English writing error correction model and applies it to the actual system to realize automatic checking and correction of writing errors in English composition. This paper uses the deep learning model of Seq2Seq_Attention model and transformer model to eliminate deep-level errors. Statistical learning is combined with deep learning and adopted a model integration method. The output of each model is sent to the n-gram language model for scoring, and the highest score is selected as output.
Baseball Related Injuries: A Case Report on Acute Compartment Syndrome of the Forearm
Authors: Pasque Charles B. , Hendrix Christopher
Published: March 2022

Acute compartment syndrome is a difficult diagnosis to make due to its wide range of clinical presentations. Delay or misdiagnosis can cause devastating consequences such as Volkmann’s ischemic contracture, permanent nerve damage, amputation, and death. Lower extremity compartment syndrome is more common than upper extremity compartment syndrome, with the forearm being the most common location for upper extremity compartment syndrome. Acute compartment syndrome is most caused by acute fracture trauma but can also be due to soft tissue crush injuries or vascular problems. We report a unique case of a male umpire being struck on the forearm by a baseball with subsequent progression to an acute compartment syndrome that required emergent fasciotomies. The patient made a full recovery with no known long-term sequelae.
Green Synthesis of Iron Oxide Nanoparticles Using Hibiscus rosa sinensis Flowers and Their Antibacterial Activity
Authors: Buarki F. , AbuHassan H. , Al Hannan F. , Henari F. Z.
Published: March 2022

Iron oxide nanoparticles (α- Fe2O3) were synthesized using an unconventional, eco-friendly technique utilizing a Hibiscus rosa sinensis flower (common name, China rose) extract as a reducer and stabilizer agent. The microwave method was successfully used for the synthesis of iron oxide nanoparticles. Various volume ratios of iron chloride tetrahydrate to the extract were taken and heated by the microwave oven for different periods to optimize iron oxide nanoparticle production. The synthesized iron oxide nanoparticles were characterized using the ultraviolet-visible spectrometer (UV-Vis), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and X-ray diffraction (XRD). X-ray diffraction confirmed the formation of α- Fe2O3 nanoparticles (hematite). The average size of iron oxide nanoparticles was found to be 51 nm. The antibacterial activity of the synthesized iron nanoparticles was investigated against different bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, and Escherichia coli. The results showed that the synthesized iron nanoparticles exhibited an inhabitation effect on all studied bacteria.
Web Simplification Prototype for Cognitive Disabled Users
Authors: Kamran Maira , Malik Marium , Iqbal Muhammad Waseem , Anwar Muhammad , Aqeel Muhammad , Ahmad Sana
Published: March 2022

Information and communication technology (ICT) and World Wide Web (WWW) are increasingly being used in daily life and becoming important in community, business, personal performance, and improvement of livelihood. people with disabilities (PWDs) can easily perform many tasks using WWW which might be difficult or impossible for them. However, many websites applications such as e-learning, e-commerce, and e-government are not specifically designed keeping in view PWD users. Through the web accessibility guidelines, web developers can build a web program accessible to PWDs. In this paper, we have investigated the issues related to website design that make it unavailable for PWDs. Keeping in view these issues, we have built a framework to make the web easier for PWDs. In addition, these issues are assessed using the GTmetrix, Netcraft, and WAVE accessibility tools and the results are generated using Google Analytics. Based on these results, we have proposed a simplified web version to improve website access for people with disabilities. The proposed prototype is also implemented on a website called Easywebcare by incorporating our recommendations for resolving the investigated issues. Analytics shows that the proposed type surpasses all existing activities in improving website accessibility for people with disabilities.
Taking 200 mg Vitamin C Three Times per Day Improved Extraction Socket Wound Healing Parameters: A Randomized Clinical Trial
Authors: Pisalsitsakul Nanthanut , Pinnoi Chaiwat , Sutanthavibul Narueporn , Kamolratanakul Paksinee
Published: March 2022

Vitamin C is essential for wound healing. However, there are no reports concerning the effect of a different dose of vitamin C on extraction wound size clinically. Therefore, the aim of this study was to investigate the effect of different oral vitamin C doses on extraction wound healing. A split-mouth, double-blind randomized clinical trial was performed in 42 patients who underwent symmetric bilateral noninfected premolar extraction. The patients were randomly divided into 3 groups, namely, P/600, P/1,500, and 600/1,500 (14 patients for each group); P/600: placebo vs. 600 mg vitamin C/d, P/1,500: placebo vs. 1,500 mg vitamin C/d, and 600/1,500: 600 mg vitamin C/d vs. 1,500 mg vitamin C/d. Patients were prescribed placebo or/and vitamin C three times a day for 10 days after each tooth extraction. Extraction wound size and pain score were evaluated. The wound assessment was performed on day 0, 7, and 21; and then the tooth on the other side was extracted using the same protocol. Pain score was recorded on the first three days after extraction. The reduced size of mesiodistal extraction wound in percentage reduction between day 0 and 7 of teeth receiving vitamin C 600 mg/d was more than that in placebo (

P
<
0.05

). Pain scores on day 1–3 of teeth receiving vitamin C 600 mg/d were significantly lower than the placebo side (

P
<
0.05

). Taking oral vitamin C 600 mg/d over three doses for 10 days after tooth extraction enhances extraction wound healing by reducing mesiodistal extraction wound and reduces postoperative pain.
Electroacupuncture Alters BCI-Based Brain Network in Stroke Patients
Authors: Song Zuoting , Zhan Gege , Lin Yifang , Fang Tao , Niu Lan , Zhang Xueze , Wang Hongbo , Zhang Lihua , Jia Jie , Kang Xiaoyang
Published: March 2022

Goal. Stroke patients are usually accompanied by motor dysfunction, which greatly affects daily life. Electroacupuncture is a kind of nondrug therapy that can effectively improve motor function. However, the effect of electroacupuncture is hard to be measured immediately in clinic. This paper is aimed to reveal the instant changes in brain activity of three groups of stroke patients before, during, and after the electroacupuncture treatment by the EEG analysis in the alpha band and beta band. Methods. Seven different functional connectivity indicators including Pearson correlation coefficient, spectral coherence, mutual information, phase locking value, phase lag index, partial directed coherence, and directed transfer function were used to build the BCI-based brain network in stroke patients. Results and Conclusion. The results showed that the brain activity based on the alpha band of EEG decreased after the electroacupuncture treatment, while in the beta band of EEG, the brain activity decreased only in the first two groups. Significance. This method could be used to evaluate the effect of electroacupuncture instantly and quantitatively. The study will hopefully provide some neurophysiological evidence of the relationship between changes in brain activity and the effects of electroacupuncture. The study of BCI-based brain network changes in the alpha and beta bands before, during, and after electroacupuncture in stroke patients of different periods is helpful in adjusting and selecting the electroacupuncture regimens for different patients. The trial was registered on the Chinese clinical trial registry (ChiCTR2000036959).
Stimulating the Professional and Personal Self-Development of Future Teachers in the Context of Value-Semantic Orientation
Authors: Madin Zhilgildinova , Aizhana Abibulayeva , Nurgul Sultanova , Alma Yedigenova , Nursultan Seksenbayev , Al Ayub Ahmed Alim , Mengesha Robso Wodajo
Published: March 2022

The actualization of value-based approaches to vocational education is determined by the presence of several contradictions, among which it is necessary to name the following: the need for educational practice in more productive means; the implementation of a humanistic educational paradigm and the unpreparedness of teachers to use them; the need for teachers with formed attitudes towards value attitudes towards themselves, their professional activities, education, self-development, to the people around them, and the lack of an effective system of pedagogical tools for solving the abovementioned problem in the process of professional training of future teachers; and the particular importance of the axiological component of the content of vocational education and its insignificant component at the level of the educational process. The article deals with the essence of professional thinking of the teacher, ways and means to develop its value-semantic component in the process of learning pedagogy, problematic dialogue, analysis of texts, promotion, and other professional reflection.
Short-Term Adverse Pregnancy Outcomes in Women with Subclinical Hypothyroidism: A Comparative Approach of Iranian and American Guidelines
Authors: Mir Farahnaz , Chiti Hossein , Mazloomzadeh Saeideh
Published: March 2022

Introduction. Subclinical hypothyroidism during pregnancy can be associated with numerous adverse outcomes. The purpose of this study was to compare short-term adverse pregnancy outcomes in treated versus nontreated patients who fall within the numerical range of thyroid-stimulating hormone (TSH) between the Iranian and American reference ranges. Materials and Methods. Eighty pregnant women with a known level of antithyroid peroxidase (anti-TPO) and TSH levels of 2.5–3.9 mIu/L in the first trimester and 3–4.1 mIu/L in the second and third trimesters were enrolled in the study and randomly assigned into two groups including 41 patients in the intervention group and 39 in the control group. The intervention group was treated with levothyroxine at least 50 μg/day and the control group received no treatment. The data were analyzed by SPSS software version 23. Results. The only significant findings were a correlation between pregnancy loss frequency (p − 0.011) and/or increased TSH level in the follow-up period (p = 0.008) with anti-TPO antibody positivity. Forty-four percent of mothers with positive anti-TPO Ab needed treatment initiation with levothyroxine, based on Iranian guidelines, due to increased TSH level during the follow-up period. Conclusion. Untreated pregnant women with subclinical hypothyroidism, who were placed in the intermediate range of TSH, recommended by Iranian and American guidelines, did not show any significant difference in short-term adverse pregnancy outcomes compared to the treated patients. Positive anti-TPO Ab may play a role in the development of short-term complications in mothers with subclinical hypothyroidism or it may increase the likelihood of an increase in TSH level during pregnancy.
Epidemiologia das fraturas do terço proximal do fêmur em pacientes atendidos no hospital geral de Nova Iguaçu – HGN1.
Authors: Rezende Rafael Torres , Medronho Junior Marco Antônio Joaquim , Andrade Filipe Moreira de
Published: March 2022

Fraturas do fêmur proximal e seu manejo continuam sendo um assunto de grande atenção para os médicos. A osteoporose e a alta incidência de comorbidades na população de idosos pode levar a um maior risco de complicações e mortalidade. O objetivo deste estudo é analisar o perfil epidemiológico das fraturas do terço proximal do fêmur em pacientes tratados no Departamento de Ortopedia do Hospital Geral de Nova Iguaçu. Foi realizado um estudo retrospectivo, analítico e observacional, desenvolvido no Hospital Geral de Nova Iguaçu. Os dados foram coletados mediante análise de 94 prontuários no período de julho de 2018 a setembro de 2018. Após organizadas em planilhas, as informações foram analisadas estatisticamente com o auxílio do software R-project, versão 3.5.3. O teste para verificar a associação entre as variáveis foi o teste de Qui-Quadrado de Pearson. Houve prevalência do sexo masculino, com 52,13% dos casos. Dos 94 pacientes, 87 tinham idade acima de 41 anos e 74,47% dos pacientes, chegaram ao hospital por meios próprios. A queda da própria altura foi o principal tipo de trauma com 86,18% e 53,20% dos pacientes foram diagnosticados com fratura transtrocanteriana. Este estudo reforça a importância social da fratura de fêmur em idosos e a necessidade de implementação de ações em saúde que reforcem a necessidade políticas públicas para que haja uma atenção específica para este grupo.
Em busca do melhor aproveitamento de bolsas de concentrado de hemácia de baixo volume
Authors: Estácio Adriana Guimarães , Brito Junior Lacy Cardoso de
Published: March 2022

INTRODUÇÃO. A produção de bolsas de sangue total com volume inferior ao esperado é prevista na Portaria de Consolidação no 05/2017, porém, a sua dispensação hoje leva em consideração apenas o teor de hemoglobinas e hematócrito da bolsa. OBJETIVO. Determinar, a partir dos parâmetros técnicos brasileiros existentes, os critérios para o melhor aproveitamento para bolsas de concentrados de hemácias de baixo volume (CHBV) produzidas na Fundação HEMOPA. MATERIAL E MÉTODOS. Foram analisados volume, teor de hemoglobina e hematócrito de 525 bolsas de CHBV provenientes de bolsas duplas sem adição de conservante; triplas convencional com adição de SAG-M (soro fisiológico, adenina, glicose e manitol); triplas top and bottom (TAB) com adição de SAG-M; e quádruplas TAB com filtro “in line” e adição de SAG-M. RESULTADOS. Foi observado que 71,43% (375/525) das bolsas de CHBV, independente do tipo da bolsa, apresentavam-se em conformidade para hematócrito e teor de hemoglobina em relação à legislação. As bolsas duplas e triplas convencionais apresentaram os maiores valores de teor de hemoglobina. Observou-se ainda que as bolsas de sangue total coletadas com volumes entre 350 e 404 ml geraram bolsas de CHBV com os menores índices de descarte. O maior descarte das bolsas de CHBV ocorreu quando o volume final £ 250 mL e hemoglobina £ 16 g/dL. Conclusão. Observou-se que o melhor aproveitamento das bolsas de CHBV ocorreu quando as bolsas de sangue total se encontravam com volumes entre 350 e 404 mL e as bolsas de CHBV apresentavam volume final ≥ 250 mL e hemoglobina ≥ 16g/dL.
Ejercicios físicos en los niveles de Síndrome de Burnout y la Variabilidad de la Frecuencia Cardíaca de estudiantes universitarios
Authors: Rosales-Ricardo Yury , Caiza Marco Vinicio , Sánchez-Cañizares Mauricio , Ferreira José Pedro
Published: March 2022

Los programas de intervención para prevenir o tratar el Síndrome de Burnout son esenciales para mejorar la salud de los estudiantes. Pero la mayoría de las investigaciones realizadas son intervenciones psicológicas y cognitivas.
Objetivo: Determinar los efectos de los ejercicios físicos en los niveles de Síndrome de Burnout y la Variabilidad de la Frecuencia Cardíaca en estudiantes universitarios.
Métodos: Estudio experimental con pre-test y post-test, con 2 grupos de intervención y un grupo de control.  La muestra fue probabilística y estratificada con participación proporcional. Instrumentos utilizados: Maslach Burnout Inventory Students Survey (MBI-SS) y Variabilidad de la Frecuencia Cardíaca (HRV): cálculo de la media RR, SDNN y RMSSD. Para el ejercicio físico, se aplicaron ejercicios aeróbicos y de fuerza durante 3 sesiones semanales de una hora, en días alternos, durante 16 semanas.
Resultados: El grupo de aeróbicos con Agotamiento MBI-SS fue mayor, reduciendo sus niveles en un 26,4% (d=0,532), en Cinismo (-21,06, d=0,252) y en Eficacia (-13,11, 0,397). Grupo de fuerza en Cinismo (-27,38, d=0,315), en Eficacia (-21,69, d=0,704), Agotamiento (-19,55, d=0,299). El grupo de control Agotamiento aumentó en un 10,26% (d=0,128). En la HVR, con el grupo aeróbico el SDNN tuvo el mayor cambio porcentual, con un aumento del 24,82 %, sobre la media RR y RMSSD (14,40 % y 16,45 %). En el grupo de fuerza y en el grupo de control (21,77%, 14,24%, 12,60%; y 12,59%, 4,97% y 4,99% respectivamente).  Hubo un cambio en el RR medio en los grupos aeróbico y de fuerza (d = 1,281 y 1,328).
Conclusiones: Efecto de reducción del síndrome de burnout y efecto contrario de incremento de valores del HRV.
Dermatite de contato agravada por outra sensibilidade em automedicação
Authors: Belluco Paulo Eduardo Silva , Azevedo Fabíola da Silva Maciel , Lima Cejana Rebouças Fernandes de , Belluco Rosana Zabulon Feijó , Reis Carmélia Matos Santiago
Published: March 2022

Dermatite alérgica de contato é uma doença cutânea inflamatória, não infecciosa, cuja base do tratamento é a identificação e eliminação do agente causal. Cocoamidopropil betaína é um surfactante muito utilizado nos produtos de uso pessoal, notadamente de uso capilar. Essa substância não está presente na bateria padrão brasileira. Neomicina é um antibiótico usado em preparações tópicas. Objetivamos mostrar paciente que desenvolveu alergia no couro cabeludo e que fez erroneamente automedicação com produto que continha substância a qual era ainda mais sensível. O caso é de uma mulher, 36 anos, evoluindo há dois meses com eczema pruriginoso, em áreas de implantação capilar e nuca. Relatava progressiva piora. Diante da suspeita de dermatite de contato, foi realizado teste de contato, utilizando-se da bateria padrão Latino-Americana. Com 96 horas (D4) evidenciou-se positividade leve (+) para cocoamidopropil betaína e forte (++) para neomicina. O resultado positivo para a neomicina foi intrigante, uma vez que a observação do rótulo dos produtos de uso pessoal não a continha. Diante do resultado do teste, após ser questionada novamente, ela confirmou a omissão da automedicação diária com pomada de neomicina. Em conclusão, mostramos a alergia a produtos de uso capilar. Reforçamos a necessidade de se fazer um teste de contato com bateria padrão atualizada. Por fim, alertamos sobre o risco da automedicação.
Desempenho do escore prognóstico de Glasgow no câncer gástrico
Authors: Figueiredo Higino Felipe , Da Rosa Rosane Dias , Fujimoto Luciana Botinelly Mendonça , Pereira Renata Motoki Amorim , Westphal Fernando Luiz , Nakajima Gerson Suguiyama
Published: March 2022

A resposta inflamatória sistêmica e o déficit nutricional são características frequentes nos pacientes com câncer e o escore prognóstico de Glasgow tem se mostrado excelente valor prognóstico no câncer gastresofágico e ferramenta validada na avaliação clínica de pacientes com câncer. Assim, o presente estudo teve como objetivo analisar a associação do escore prognóstico de Glasgow com sobrevida de pacientes portadores de carcinoma gástrico, através de revisão sistemática e meta-análise. Foi seguida a metodologia Preferred Reporting Items for Systematic Reviews and Meta-Analyses-PRISMA, com pesquisa nas plataformas Medline, Web of Science e SCOPUS, utilizando descritores apropriados. Foram incluídos estudos clínicos e observacionais, publicados antes de 30.09.2017 e sem restrição de linguagem. Os critérios de inclusão foram a utilização do escore prognóstico de Glasgow como fator prognóstico em pacientes portadores de diagnóstico histológico de carcinoma gástrico; com idade superior a 18 anos; submetidos à quimioterapia, radioterapia ou cirurgia; com dosagem de Proteína C Reativa e albumina no pré-tratamento; e com dados referentes à sobrevida durante o estudo. A qualidade dos estudos foi avaliada com a Escala de Newcastle-Ottawa e o risco de viés com ferramenta da Cochrane Collaboration. Hazard-Ratio e Intervalo de Confiança de 95% foram extraídos dos estudos, e a significância estatística definida como p<0,05. Foram identificados 255 artigos, e por fim, analisados 15 estudos. A análise apresentou o escore prognóstico de Glasgow como fator de risco relacionado à sobrevida e considerado marcador prognóstico independente quando relacionado à sobrevida global dos pacientes com câncer gástrico que realizaram cirurgia e quimioterapia.
Infecção de loja de cardioversor-desfibrilador implantável (CDI) por klebsiella sp. Carbapenem-resistente
Authors: Gâmbaro Gustavo Aliano , Moura Rebecca Amaral Pires , Reis Gustavo Galli , Furtado Fabrício Nogueira
Published: March 2022

As infecções associadas aos Dispositivos Cardíacos Eletrônicos Implantáveis (DCEI) apresentam uma incidência de até 3,4% e notável impacto na morbidade e mortalidade dos pacientes. As bactérias Gram-positivas, especialmente do gênero Staphylococcus sp. representam 60-70% dos agentes isolados. Por sua vez, as Gram-negativas correspondem até 9% dos casos. Relatamos uma infecção de loja de gerador de Cardioversor-desfibrilador implantável (CDI) por uma Klebsiella sp. resistente aos carbapenêmicos, em um paciente masculino jovem, cujo desafiador diagnóstico de certeza desse caso somente foi possível após exploração cirúrgica e cultura do material da loja do CDI, haja vista a apresentação clínica oligossintomática. Embora já descritas, Klebsiella sp. são raras nesse contexto e em nosso conhecimento, esse é o primeiro relato de uma infecção de DCEI por uma enterobactéria resistente a carbapenêmico.
Perfil clínico e nutricional de crianças com alergia à proteína do leite de vaca
Authors: Jordani Maísa Tirintan , Guimarães Isabela Garcia da Cunha , Silva Taísa Alves , Alves Luciene , Braga Camila Bitu Moreno , Luz Sylvana de Araújo Barros
Published: March 2022

OBJETIVO: Este estudo teve como objetivo identificar as principais características clínicas e nutricionais apresentadas pelas crianças com alergia à proteína do leite de vaca. MÉTODO: Tratou-se de um estudo observacional, transversal, quantitativo e correlacional, com amostra de conveniência, constituída por 22 crianças diagnosticados com alergia em diferentes estágios, na faixa etária de 6 meses a 6 anos, atendidas no ambulatório de Gastroenterologia Pediátrica do Hospital de Clínicas da Universidade Federal do Triângulo Mineiro. RESULTADOS: Evidenciou-se eutrofia em 81,8% das crianças, risco de sobrepeso em 4,5%, sobrepeso em 9,1% e obesidade em 4,5%. Nenhum dos pacientes apresentou diagnóstico nutricional de magreza. Os sintomas gastrointestinais (diarreia, vômito e sangue vivo nas fezes) foram os que mais acometeram os pacientes avaliados. Todos os pacientes (100%) com alergia em remissão e alergia resolvida mostraram nível de ferritina sérica normal, porém, 14,3% das crianças em alergia ativa estavam com esse valor abaixo do recomendado para idade. As crianças apresentam desmame precoce do leite materno, alimentação complementar dentro do que é indicado e o uso de fórmulas infantis corretas para atingir as recomendações nutricionais para a idade. CONCLUSÃO: Os achados indicam que o perfil clínico e nutricional de crianças com alergia está em conformidade com o esperado no que tange à escolha das fórmulas e desenvolvimento das crianças.
Tumor de Células Gigantes em porção anterolateral de costela
Authors: Santos Caique Rodrigues dos , Abreu Marcus Matta , Ferreira Juliana Dias Nascimento , Toledo Laura Melo Werneck de , Moreira Maria Luísa Bezerra , Rezende Sávio Mourão
Published: March 2022

O Tumor de Células Gigantes é uma neoplasia osteolítica benigna, porém agressiva, ricamente vascularizada e com numerosas células gigantes com atividade osteoclástica. Ocorre mais frequentemente nas epífises de ossos longos e raramente acomete as costelas (cerca de 1% dos casos). A apresentação deste tumor em porção anterolateral de arco costal é extremamente rara em comparação com a região posterior. O presente relato descreve o caso de uma paciente que apresentava uma tumoração dolorosa em parede torácica anterolateral esquerda, de crescimento insidioso. Exames de imagem revelaram uma lesão insuflativa em 10º arco costal esquerdo (4,2 x 3,5 cm), com áreas de calcificação interior. A paciente foi submetida a tratamento cirúrgico, com ressecção ampla do tumor, englobando 9º, 10º e 11º arcos costais e uma porção do diafragma. O diagnóstico definitivo de tumor de células gigantes se deu pela imunohistoquímica da peça cirúrgica. Este relato permite fornecer bases para o estudo das possibilidades terapêuticas desta patologia em localizações atípicas, reforçando que a exérese em bloco com margens amplas destes tumores promove uma menor chance de recidiva local.
Adesão à terapêutica medicamentosa e fatores associados em Diabetes Mellitus tipo 2.
Authors: Botrel Felipe Zacaroni , Faria Karine Joice , Silva Barbara Aléxia Batista e , Nascimento Gabriela Franco , Diniz Mariana Moreira , Morais Aisha Aguiar , Cortez Daniel  Nogueira
Published: March 2022

Introdução: o Diabetes Mellitus tipo 2 (DM2) é condição crônica que frequentemente cursa com baixa adesão ao tratamento. Objetivo: o presente estudo avaliou a prevalência de adesão à terapêutica medicamentosa e fatores associados em pessoas com DM2 assistidas pela Estratégia Saúde da Família (ESF). Método: trata-se de estudo observacional transversal realizado na ESF da zona urbana de um município de médio porte de Minas Gerais, com amostra randômica de 190 participantes. Foram utilizados dois instrumentos validados: Medida de Adesão ao Tratamento (MAT), que avalia o uso diário de medicamentos prescritos, e teste de Batalla, que avalia adesão através do conhecimento em DM2. O perfil socioeconômico e clínico foi coletado por questionário elaborado pelos autores. Principais resultados: a adesão avaliada pelo MAT (84,2%) se contrapôs àquela estimada pelo teste de Batalla (44,2%). Maiores valores apresentados pelo MAT obtiveram associação significativa com polifarmácia (OR=2,7; IC 95%=1,2-6,1). Melhor adesão pelo teste de Batalla obteve associação com idade abaixo de 60 anos (OR=3,7; IC 95%=1,9-7,1), presença de companheiro (OR=2,2; IC 95%=1,1-4,1), associação de antidiabético oral à insulina (OR=2,2; IC 95%=1,2-4,0) e cumprimento da meta de atividade física (OR=2,6; IC 95%=1,2-5,6). Conclusão: os índices de adesão ao uso diário de medicamentos e conhecimento em DM2 verificados pelo estudo são concordantes com a literatura. Piores resultados presentes na população idosa e sem companheiro evidenciam grupo vulnerável que deve receber especial atenção das equipes de saúde.