bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic transformation of Datura stramonium for the production of tropane alkaloids in hairy root cultures
Authors:   , Ally Farnaaz
Published: June 2022

Datura stramonium is well known for its tropane alkaloid content, specifically atropine and scopolamine. With the demand of tropane alkaloids in the pharmaceutical sector, as anti cholinergic agents, anesthetic or its use in transdermal patches, an alternate method to obtain higher yields is required. In addition, much interest has been developed around the plant for its potential biological profile due to its use in traditional medicine. This study investigated the potential production of tropane alkaloids in plant tissue cultures and the biological activity in crude extracts of D. stramonium. Elicited hairy root cultures had displayed the highest atropine and scopolamine content as compared to in vitro leaf and callus culture extracts. The concentrations of atropine and scopolamine was 5.2 µg.mL-1 and 5.01 µg.mL-1 respectively. This was an increase of 1.57 and 1.21 fold respectively as compared to wild plant extracts. The biological profile of D. stramonium was investigated by determining its antimicrobial activity and anti-oxidant activity. The anti bacterial activity wsas investigated by the Kirby-Bauer disc diffusion assay. Root extracts displayed a broader spectrum of bactericidal activity (7 mm – 33 mm) as compared to leaf extracts. No fungicidal activity was displayed by both extracts. The anti oxidant activity was investigated using 2-diphenyl-1-picrylhydrazyl (DPPH) photometric assay. The activity displayed was dose dependant, i.e.; as the extract concentration increased, so did the anti oxidant activity. At a concentration of 1 µg.mL-1 , the radical scavenging capacity of root and leaf extracts was 64.4% and 31.7% respectively whereas, at the highest concentration of 1000 µg.mL-1 , the radical scavenging capacity of root extracts and leaf extracts was 98.4% and 45.8% respectively. The biosafety evaluation of leaf and root extract demonstrated a linear relationship between the concentration of extracts and percentage toxicity. As the concentration and exposure period of the extracts increased, the toxicity towards A. salina had also increased. These results indicated the potential of plant, cell and tissue culture systems of D. stramonium to produce higher yields of atropine and scopolamine through optimization, and the potential of anti oxidant and anti bacterial components present in its leaf and root.
The primary caregiver’s stress: its correlation with the chronological and diagnostic age of children with autism spectrum disorder
Authors: Aslam Zeenaf , Ghani Mansoor , Manzoor Samina , Rahman Saeed Ur , Aslam Asdia , Sumreen Anila , Naz Afshan Mehvish , Batool Asma
Published: June 2022

Background and Objective: Autism is a neurodevelopmental and heterogeneous disorder that affects people of all ages; also known as autism spectrum disorder (ASD). Nurturing these children puts a tremendous burden on the primary caregivers. It may be due to some compelling reasons, including existential concerns to unknown etiology of autism and lack of understanding of its nature. The aim of the study was to evaluate the stress level in the primary caregivers and its relationship with child’s chronological and diagnosis age.

Methods: This cross-sectional study included 96 primary caregivers (mothers, fathers, siblings, and grandparents) of children diagnosed with ASD reporting at government and non-government institutes of Lahore city. The childhood autism rating scale was used to confirm the diagnosis of autistic children. The parent stress scale was used to evaluate stress levels in primary caregivers.
Results: The mean age of the autistic children was 5.1 ± 2.5 years, while the mean age at the time of diagnosis was 3.2 ± 1.1 years. The mean stress score was recorded as 52.3 ± 7.3, with the range of 36.0-70.0. No correlation (r = 0.015) was observed between stress score of primary caregivers and duration after diagnosis of autism in these children. However, negative associations (r = -0.044) were seen between primary caregiver’s stress and child’s chronological age.
Conclusion: The majority of primary caregivers indicated bearing a significant level of stress, especially in managing the child in earlier years after diagnosis. Appropriate education, counseling, and rehabilitation services may play an important role in reducing the anxiety and stress over time in caregivers as the child’s age increases.
Antibiotics prescribing practices for sore throat in a sub-urban primary care clinic
Authors: Naveed Babra , Arif Khadija Amna , Jawaid Hina , Zia-ul-Hassan
Published: June 2022

Background and Objective: Antimicrobial resistance (AMR) is one of the serious health problems in Pakistan. Excessive use of antibiotics during pandemics has aggravated AMR; hence, rational use in the future is even more important to consider and implement. Clinical audits on antibiotic prescribing in general practice can help improve antimicrobial stewardship. This study was designed as an audit to evaluate if the antibiotics prescribed for Streptococcus pharyngitis at a sub-urban primary care center in Pakistan were in line with the standard and latest guidelines.
Methods: A retrospective audit was carried out at the primary care center located at Nainsukh, Lahore, Pakistan during 1 month period. Both adult and pediatric patients (above 3 years of age) presenting with upper respiratory tract infections were included in the study. A total of 48 consultation cards were identified using International Classification of Diseases 10 coding. The antibiotic prescribing practice of primary care physicians was evaluated against the Modified Centor Criteria (MCC) which was used as a standard. A score of ≤3 required no antibiotic whereas a score of ≥ 3 needed a same-day antibiotic prescription for sore throat.
Results: There were 28 (58.3%) patients presenting with MCC of ≤3 and were not given antibiotics. Antibiotic prescriptions issued on the day of presentation were n = 20; however, only n = 7 (35%) met the standard criteria, i.e., MCC score of ≥3 and among these patients, penicillin remained the first choice with 71% patients receiving amoxicillin, while 28% received co-amoxiclav.
Conclusion: Antibiotic stewardship is lacking among general physicians working at the sub-urban primary health care center in Lahore city. Clinical audits, as a part of clinical governance, may help improving the quality of care provided to the community by the regional primary health care physicians.
Will men tie their violet ribbons? Testicular cancer and testicular self-examination
Authors: Qadri Haseeb Mehmood , Qayyum Fahad
Published: June 2022

The American Association for Cancer Research has declared the month of April as the global awareness month of Testicular Cancer (TC). Worldwide, TC is the most frequently reported malignancy in males aged 20 – 40 years. Testicular Cancer and Testicular Self Examination awareness should be started at home. This clinical poster is an easy approach to making the general public attending the outpatient department, understand the very basics of TC & TSE.
Agonists and antagonists of the orexinergic system: therapeutic molecules of the future - a narrative review
Authors: Akram Zunaira , Ghafoor Sarah
Published: June 2022

The orexinergic system involves orexin (OX) neurons, OX peptides, and OX receptors. OX neurons are located throughout the central nervous tissue (including many nuclei) and the peripheral nervous tissue and organs. These neurons are critically involved in the sleepwake transition, cardiorespiratory, and autonomic regulations. OX antagonists include selective OX type 1 receptor (OX1R) antagonists, selective OX type 2 receptor (OX2R) antagonists, and dual OX1/2R antagonists. Similarly, OX agonists include dual OX1/2R agonists and selective OX1R or OX2R agonists. Recent understandings of the therapeutic mechanism of OX have led to possible therapeutic options in diseases such as insomnia, narcolepsy, psychiatric disorders, and neurodegenerative diseases. This review focuses on the therapeutic roles of OXs as agonists or antagonists in animal models and human patients, which can lead to possible avenues related to their application in health and disease.
Ketogenic diet: knowledge, awareness, and perception among university students in Saudi Arabia
Authors: Alshaikh Nahla Ali
Published: June 2022

Background and Objective: Ketogenic diet (KD) has gained a high popularity recently. It is extensively used for weight reduction besides its therapeutic use in some diseases. The aim of this study was to determine the awareness, knowledge, and perception about KD, its therapeutic uses, and side effects among university students in Saudi Arabia.
Methods: This survey-based study was conducted at Jazan University, Jazan, Saudi Arabia, during the month of December, 2021. A validated and pretested questionnaire was electronically distributed via a Google Drive link to collect data from the students enrolled in the study. Data were computed using correlation statistics.
Results: A total of 701 students completed the questionnaire. Among all students, 64% were females and 64.6% were studying in non-health related specialties. Majority of the students (84.8%) had heard about KD at the time of survey administration and 70.6% knew someone who were using KD. More than half (69.5%) of the students reported weight loss as the purpose of KD use. Most of the participants did not know about the therapeutic use of KD for diabetes and epilepsy (58.9% and 81%, respectively). Majority of the students did not know about most of the adverse effects of KD; however, 87.2%, 79.7%, and 80.9% of the participants had a perception that everyone cannot follow KD, it is not safe to follow KD lifelong, and the diet has to be recommended and supervised by a physician, respectively.
Conclusion: The study shows that students had low knowledge about KD’s therapeutic uses and side effects. Weight loss was considered as the main purpose for using KD. Most of the students rightfully perceived the importance of consulting a physician before adopting this diet plan.
Persepsi Pemangku Kepentingan terhadap Partisipasi Masyarakat dalam Pembangunan Desa Sekitar Tambang
Authors: Ihsan Mattalitti Muhammad
Published: June 2022

This study aims to present the results of a case study on stakeholders' perceptions of community participation in village development activities around mining area in a village in Central Sulawesi. Data were collected from 12 participants through in-depth interviews. Using content analysis and community participation in development as analytical framework, the results of data analysis depict that the community acknowledges the village government’s various efforts to encourage community participation through community development and community involvement in village development. However, the community involvement in village development is still lacking due to limited villagers’ participation. One of the reliant factors for the low participation is because most of the residents are mining workers.
The use of Functional Resonance Analysis Method (FRAM) to model an emergency response plan
Authors: Bouasla Seif El Islam , Zennir Youcef , EL-Arkam MECHHOUD
Published: June 2022

Accident models, analysis methods and emergency response plans affect what accident investigators and emergency response leaders look for, which contributing factors are found, and which recommendations are issued. This paper contrasts the Functional Resonance Analysis Method (FRAM) for an emergency response plan. FRAM illustrates the dynamic interactions within socio-technical systems and lets the analyst understand the how and why by describing non-linear dependencies, performance conditions, variability, and their resonance across functions. So, it defines a systemic framework to model complex systems from the perspective of function and views accidents and emergency response strategies as emergent phenomenon of function’s variability, It is playing an increasingly significant role in the development of systemic emergency response plan.
Safety Integrity Evaluation of crude oil heater According to IEC 61508 Standard
Authors: DIB KHAWLA , ZENNIR YOUCEF , BOUNEZOUR HICHEM , BOUASLA SEIF EL ISLAM
Published: June 2022

the main object of this paper is to evaluate safety barriers intervening against overpressure implemented on a crude oil heater using layers of protection analysis approach suggested in IEC 61508 (International Electrotechnical Commission) Standard for the determination of safety requirements are illustrated. Accident scenarios are pre-identified using Hazard an Operability approach, Fault tree approach is required for an effective risk assessment process. In order to better appreciate accident scenarios, PHAST (Process Hazard Analysis Software Tool) is utilized to simulate them.
Transient Simulation of an Industrial Steam Boiler
Authors: Deghal Cheridi Amina Lyria , Dadda Amel , Bouam Abdellah , Dahia Ahmed
Published: June 2022

The safety analysis of an industrial installation is extensively based on modeling and simulation. However, the analysis of simulation using realistic computer codes like RELAP5/Mod3.2 will help understand thermal-hydraulic behavior of an installation during normal and accidental conditions. In a steam boiler operation, it is very important to evaluate numerous accident scenarios under real plant conditions. One of the main accidental transients is tube rupture of steam boiler. The main objective of this study consists toinvestigate the behavior of an industrial steam boiler installed in the complex of natural gas liquefaction (LNG) at Skikda in Algeria during feed water line break accident. A RELAP5 model was set up to simulate the entire system, the model represents all steam boiler components to be suitable for the analysis of the several accidents. The control and regulation systems are also considered. The model was qualified against the steam boiler data at steady-state conditions. As seen from the results, a good agreement was obtained. The transient simulation results show that the thermal-hydraulic code correctly predicts the behavior of the main steam boiler parameters and how the control system, when required, can successfully mitigate the accident.
ДИФЕРЕНЦІАЦІЯ УМОВ ІНКЛЮЗИВНОГО РОЗВИТКУ СІЛЬСЬКИХ ГРОМАД
Authors: Павлик Володимир
Published: June 2022

Викладено нормативні документи, які зазначають актуальність виявлення відмінностей в інклюзивному розвитку територіальних громад. Запропоновано інноваційне рішення щодо вирівнювання, вимірювання показників, які характеризують диференціальні соціальні, економічні, політичні умови розвитку територіальних громад.
COGNITIVE APPROACH IN TEACHING READING OF FOREIGN MEDICAL STUDENTS
Authors: Senik L. , Ragrina Z.
Published: June 2022

The article is devoted to the one of important problems of modern pedagogics such as teaching of professional reading of foreign medical students. The main mental operations are highlighted. The types of reading are discussed. The main characteristics of operations are determined.
RECEPTION OF TRYPILLIA HERITAGE IN NATIVE FAITH MOVEMENT OF UKRAINE IN THE CONTEXT OF ETHNO-CONFESSIONAL IDENTITY
Authors: Bazyk Dmytro , Zavalii Alexander
Published: June 2022

One of the topical issues in modern religious studies, requiring a proper coverage, is the study of the Trypillia spiritual heritage perception by representatives of modern neo-pagan religious organizations (usually called in Ukraine as native faith or native beliefs, originally "ridnovirski" from the Ukrainian words "native" and "believe" that identification clearly indicating the autochthonous characteristics of beliefs, customs and rites represented by a particular confession). Today in Ukraine there exist a number of different religious confessions and several communities, which differ significantly from each other in their beliefs and religious practices. Despite the fact that the vast majority of native faith communities in Ukraine are patriotic and nationally oriented, historically there is a certain "chronological paradox", in that the first mention of the name "Ukraine" appears in the Kyiv chronicle in 1187, while officially the process of Ukrainian lands (that time called "Rus") christianization began in 988. Such dissonance naturally actualizes the issue of searching for an alternative ethno-confessional identity in the native faith environment, as the vector of modern native believers religious activity targets at reviving autochthonous pre-Christian beliefs and spiritual values, that is, towards an older chronological retrospective, among which objects quite often there appear the Trypillia spiritual heritage. Trypillia culture (also called Cucuteni-Trypillya) – is a Neolithic–Eneolithic archaeological culture, whose name comes from the name of the village of Trypillya in Kyiv region, it flourished between 5500 and 2750 BCE, was located between the Carpathians and the Dnieper in modern Ukraine, Moldova and Romania (Trypilian culture). The novelty of this work is that for the first time in this research perspective, the issues of both the reception of the spiritual heritage of ancient Trypillia by modern natives of Ukraine and the problem of ethno-confessional identity in the Ukrainian native movement are considered. The methodological basis of our study relays upon the conceptual work of the French philosopher Vincent Decombe (Decombe, 2015, 281 р.). In particular, the concept of "ethno-confessional identity" is a component of the collective identities concept developed by the researcher, i.e. those that formulate answers to the question: "Who are we?". At the same time, this term represents the situation of ethnic and confessional identities integration, which in the context of understanding the religious processes of the native-faith movement in Ukraine do appear as an actual phenomenon of religious life in its inseparable integrity. The research publication highlights the problem through the prism of the most prominent religious confessions and communities in the religious field of Ukraine, which render certain visions regarding their own reception of the ancient Trypillians spiritual heritage.
СОЦИАЛЬНОЕ КОНСТРУИРОВАНИЕ СЕМЬИ И БРАКА В СССР В 20-Е ГОДЫ ХХ ВЕКА
Authors: Белова Наталья
Published: June 2022

В целом дискурс в отношении семьи и брака Советского государства 20-х годов XX в. распадается на два больших пласта: гендерный дискурс и дискурс брака. Анализируя гендерный дискурс в СССР 20-х годов можно проследить за тем, как идеология, и другие социокультурные факторы влияют на представления населения о гендерных ролях мужчин и женщин. В рамках данного дискурса оформлены понятия и категории («семья», «брак», мужчина», «женщина»), которые хотя и не достигли определенного абстрактного уровня отражения своего предметного поля, но выражают значения, позволяющие проводить анализ идеологических оснований семейно-брачных отношений и социального конструирование семьи и брака в СССР 20-х годов прошлого века.
МУЗИЧНЕ МИСТЕЦТВО І ВІЙНА (ВІД ПОЧАТКУ ХХ СТ. ДО СЬОГОДЕННЯ): НА ПРИКЛАДІ СПОГАДІВ ОСИПА ЗАЛЕСЬКОГО
Authors: Білінська Ольга
Published: June 2022

У статті розглядається музичне мистецтво як своєрідний фронт боротьби, розкриваються окремі факти привласнення росією української культурної спадщини й постаті композиторів, музикантів – інструменталістів, вокалістів, які обороняють територіальну цілісність України в сучасній війні. Також описано спогади музикознавця, композитора і безпосереднього учасника воєнних дій (1916-1920) Осипа Залеського, які дають змогу порівняти воєнну толерантність російських солдат на протязі століття.
ТЕХНОЛОГІЧНІ РОЗРАХУНКИ ДІЛЬНИЦІ ВІДГОДІВЛІ СВИНЕЙ НА ПРОМИСЛОВОМУ КОМПЛЕКСІ
Authors: Нагорний Сергій , Криворучко Юрій , Чалий Олександр , Чалая Ольга , Косенко Світлана
Published: June 2022

статті наведено результати хронометражних спостережень за виконанням всіх технологічних процесів і операцій на дільниці відгодівлі свиней, обробка і аналіз отриманих результатів в порівнянні з діючими в свинарстві нормами і вимогами промислового виробництва свинини, обгрунтовано технологічні регламенти, наведено технологічні розрахунки та рішення з розробки технологічних нормативів процесу відгодівлі свиней на комплексі промислового типу
SPHERICAL SHELL VIBRATIONS WITH A HOLE-TYPE DAMAGE
Authors: Fursina Anna , Kruzhnova Svitlana
Published: June 2022

The present article addresses free axisymmetric vibrations of a shallow spherical shell with a hole in the center under different boundary conditions. By using the boundary conditions for the shell with a hole, we obtain transcendent equations for determining the natural frequencies. By changing the parameter  in equations, we get a possibility of determining the frequencies at the various hole sizes. We conclude that the hole makes a very low impact on the natural vibration frequencies.
ВАРІАНТИ ВІДНОВЛЕННЯ НИЖНЬОЇ РАМИ ДУМПКАРА (ВАГОНА-САМОСКИДА) З МЕТОЮ ПОДАЛЬШОЇ МОЖЛИВОСТІ ПРОДОВЖЕННЯ ТЕРМІНУ ЕКСПЛУАТАЦІЇ
Authors: Кошель Олексій
Published: June 2022

В статті проведено дослідження стосовно можливих варіантів відновлення несівної спроможності нижньої рами думпкарів (вагонів-самоскидів) на основі розроблених розрахункових моделей у комп’ютерному комплексі SOLIDWorks. Отримані результати дали змогу вибрати оптимальний варіантів усунення типових дефектів та покращення міцнісних характеристик нижньої рами думпкарів (вагонів-самоскидів).
Manhajīyyah Tanzīl al-Aḥkām ‘alā al-Nawāzil al-Mu’āṣirah naḥw Taṭbīq Rasyīd li al-Aḥkām al-Syar’īyyah
Authors: Saputra Refki
Published: June 2022

تقع في حياة الناس نوازل ووقائع مستجدة بشكل مستمر لم تكن عند أسلافهم، فقام العلماء بدراستها وتقرير أحكامها عملا بمهمة دينية من التبليغ والبيان، واستجابة لحاجات الناس إلى معرفة توصيفها الشرعي. الاجتهاد في النوازل وتقرير أحكامها هو تنزيل أحكام الشريعة وتطبيقها على تلك النازلة، حيث رأى الفقهاء أنها محلا لتلك الأحكام، ويترتب على تنزيل الأحكام عليها حصول المصالح التي يقصدها الشارع من تشريع الأحكام. والبحث يسلط الضوء على منهجية علمية لعملية اجتهادية في تنزيل الأحكام الشرعية على النوازل والقضايا المستجدة، التي تضمن صحة التنزيل، وإصابة المجتهد عند وضع الحكم في محله، وتحقق المقاصد والمصالح الشرعية. صحة الفهم والاستنباط لم يكن مجديا إن كان التنزيل غير مصيب وغير محقق للمقاصد. ويعتمد البحث على المنهج الاستقرائي والتحليلي ويرجع إلى المصادر المعتمدة في دراسة الموضوع. ويكشف البحث أن عملية تنزيل الأحكام على النوازل لا بد أن تخضع لجملة من القواعد والأسس والمباديء التي ترسم منهجية النظر في النوازل ودراستها، وصياغة التكييف الفقهي لها، وتنزيل الأحكام الشرعية عليها.
Islamic Boarding Schools As A Basis For Character Education In The Industrial Revolution Era 4.0
Authors: Zaki Ulien Nuha  , Ahmad Afandi
Published: June 2022

Pesantren have been the initiators of institutions that provide religious education, especially Islam in the archipelago, especially when Islamic da'wah developed in the 13th century. The distinctive pattern of education with the presence of a mosque, a kiai, books, lodges, and students makes it the only original education in the archipelago. The advantage of pesantren compared to other educational institutions is its emphasis on the education of noble moral character compared to the cognitive side. This paper employed the library research method. The data were collected by analyzing/exploring some journals, books, both printed and electronic documents, and other source information that relates to the research. Pesantren have their strategies and methods when dealing with human moral education. Not only as an institution for producing virtuous people, but Islamic boarding schools also have an important role in the social dimension of society and even become a cadre institution for future leaders as a consequence of their regular forging and training for santri regarding superior individual personalities. However, currently, the capability of pesantren with its success in educating moral character is being tested in the era of high technology development known as the Industrial Revolution 4.0. A term that describes the characteristics and characteristics of the community or generation in it which is certainly different from previous generations.
Menyiapkan Khotbah Berpedoman Bahasa Asli
Authors: Wau Hasanema
Published: June 2022

Preaching is an honor, but it is also a challenging responsibility. Why? Because when preaching, one is dealing with the words and thoughts of God! Therefore, it is important for a preacher to carefully examine what the author of the text really meant. It would be a disgrace to say out loud: According to the apostle Paul or to refer to other writers and it turns out that is not what is meant. To find out the meaning of the text towards the ideal, of course, by exploring the original language of the text. The availability of various versions of the actual translation makes it easy, but it must be remembered that when the translation process takes place, the aspect of real interpretation plays a role.
Academic Information System Management To Improve Service Quality To Students During The Covid-19 Pandemicat Universities In Jambi Province
Authors: Dioputra Sepryhatin , Wahidin Didin , Iriantara Yosal , Warta Waska
Published: June 2022

Universities that have good academic service management quality standards are the goal in every university's efforts. In Jambi Province in particular, good management applied to a university is one of the important factors to improve the quality of service both for students, the community or for the university itself. Not a few universities whose academic service quality still does not meet the satisfaction threshold in the assessment, one of which is offline-based services that will usually hinder the delivery of existing information. UNAMA colleges (Universitas Stikom Dinamika Bangsa) and IAI Tebo in Jambi Province are universities where each delivery of academic information focuses on the use of computers and technology, both of these universities have implemented academic information system management, but each of these universities has advantages and disadvantages in the information system that is run, so a study is needed to be able to combine each of the advantages and disadvantages found in the two universities. By applying qualitative methods, it is hoped that it will provide useful research results,the focus of this research is directed at (1). Planning, (2). Implementation, (3). Evaluation (4). Solutions or follow-ups in improving the quality of academic services at universitiesusing Deming's cycle management theory. OnThis study uses a descriptive method with a qualitative approach and data collection by conducting observations, interviews, and documentation studies.so from the results of this study can conclude a more complete management information system that can be applied to other universities, especially those that are still offline.
The Relationship Among Quality of Care, Government Social Protection Program and Quality of Life of People with Disability: Empirical Evidence from Dili Municipality
Authors: Muganga David , Saldanha Estanislau De Sousa , Muni Joao
Published: June 2022

This research investigates the indirect effect of government social protection program on the relationship between quality of care and the quality of life of the people with disability. In addition, the study also tests the direct effect of quality of care and government social protection program on the quality of life of people with disability. Through empirical analysis using SMART-PLS 3.0, we found that government social protection program has insignificant direct effect on the relationship between quality of care and quality of life of people with disability. In addition, both quality of care and government social protection program have direct significant effect on quality of life of people with disability. Our study enriches theoretical and empirical debates on quality of care, government social protection program and quality of life of people with disability. These findings provide managerial implications and research direction.
PROGRAMMATIC SYSTEM FOR INTERACTIVE REPRESENTATION OF SCIENTIFIC INSTITUTION RESULTS
Authors: Prykhodniuk V. V. , Nadutenko M. V. , Potapov H. M.
Published: June 2022

Our time is characterized by rapidly increased information quantity. The volumes of accumulated data become so large that the manual handling of this data by experts of certain subject areas becomes almost impossible. In such circumstances, it is extremely important to develop effective tools that could provide users the information, presented in the form of large arrays of spatially and thematically distributed information resources (documents). An example of an array of spatially and thematic distributed documents is the set of information that characterizes scientific achievements of the institutions of the National Academy of Sciences of Ukraine. Such information may be useful for a wide range of users, but can bring especially great benefits to young researchers — students, engaged in scientific and educational activities. The article proposes the approach to build the information and analytical system designed to provide the access to an array of information about the achievements of scientific institutions for young researchers. The system is characterized by flexible ontology driven architecture, which allows dynamical modifying of its composition and structure for the need of a particular user or project. The article describes the architecture of the ontology driven lexicographic system, based on which the system of interactive representation of achievements is constructed. In addition, the structure and interrelations of the software components that are part of the system are described. The software system is being developed within the framework of research “Interactive Base of Knowledge of Scientific Achievements of the Institutions of National Academy of Science of Ukraine” by the researchers of National Centre “Junior Academy of Sciences of Ukraine”.
Risk of Developing Asthma After Lower Respiratory Tract Infections with Respiratory Syncytial Virus During Childhood
Authors: Farid Eman , Al-Biltagi Mohammed , Abdulla Heba , Sridharan Kannan
Published: June 2022

Background: Recent studies indicate causal relationship between infection by respiratory syncytial virus (RSV) and bronchial asthma. We evaluated the incidence of bronchial asthma in children with RSV positive infection early in their childhood in a nation-wide cohort study.

Methods: Children (aged between one month and 15 years) were evaluated for the presence of RSV infection when they presented with one or more acute respiratory tract infection symptoms (fever, cough, cold and wheezing) in a major tertiary care hospital in the Kingdom of Bahrain during a period of seven years. RSV detection was done using nasopharyngeal secretion (NPS) samples by direct antigen detection immunofluorescence technique. Number of children who were later diagnosed with asthma was recorded. Serum IgE levels were estimated. Risk of developing bronchial asthma is represented using relative risk (RR) [95% CI]. Children with asthma without prior RSV infection from the same population formed the historical control.

Results: A total of 3782 children diagnosed with respiratory tract infection were recruited. We observed that RSV infection at younger age (during infancy) and severe infection were significantly associated with asthmatic episodes RR [95% CI]: 7 [5.5, 8.2]. Additionally, asthmatics with prior RSV infection had significantly higher total IgE levels (167 ± 37 IU/ml) compared to those without RSV infection (92 ±17 IU/ml). Mean (SD) age of children developing asthma with prior RSV infection was 0.7 (0.42) years compared to the historical control [6.8 (3.8) years] and was statistically significant.

Conclusion: Infants with RSV infection have an increased risk of developing bronchial asthma later in the childhood. The more severe the RSV infection, the greater is the severity of bronchial asthma as indicted by serum IgE levels. Asthma in children with RSV infection occurs at much younger age compared to those without RSV infection.
Academic Integrity in Pre-university Learning Environments During the COVID-19 Pandemic in the Countries of the Gulf Cooperation Council
Authors: Al-Jarrah Abdelnaser D. , Al-Jasim Fatima Ahmed Ali
Published: June 2022

Purpose: The study aimed to reveal the percentage of students’ behaviors violating academic integrity in the distance-learning period during the Covid19 pandemic from the point of view of students, teachers, and parents of students. Moreover, whether they differ between students, teachers, and parents. It also aimed to reveal the differences in these practices according to the student's gender and academic level. Method: To achieve the objectives of the study, the descriptive approach was used, the sample consisted of (745) participants in the Gulf Cooperation Council countries, distributed by gender variable (464) males, (281) females, including (330) male and female students, (259) parents, and (156) teachers. To achieve the objectives of the study, the Academic Integrity Scale was prepared, and it consists of three dimensions: attending classes, performing assignment, and submitting tests. Results: The results showed that the percentage of the prevalence of behavioral practices that violate academic integrity among students was 41.5%, among parents, it was 40.4%, and in the teachers, it was 57.2%. The results also showed that there were statistically significant differences in the sample estimates of the behavioral practices of the students, and the differences were in favor of the teachers. It also showed that there were differences due to the sex of the student, on the scale, and on the field of test performance, and the differences were in favor of females. The study made several recommendations, including raising awareness of the importance of academic integrity for the teaching and learning process for all members of society and its importance in creating a transparency society, and developing various electronic methods to limit practices of violating academic integrity. Conclusion: The results of the study constitute a concern that must be addressed in order to achieve greater academic integrity for pre-university learners. Teachers feel these violations of academic integrity more than others, and the behavioral practices of violating academic integrity among female students are more than that of male students, which needs further research and study. It also emphasizes activating the role of the academic advisor in the school to reduce this phenomenon as it represents self-deception for the student, and threatens the value system of society.
General overview on SARS-CoV-2 and potential role of natural compounds as antiviral drugs targeting SARS-CoV-2 proteins
Authors: Dassamiour Saliha , Ghebache Widad , Garbi Hala
Published: June 2022

Purpose: The novel coronavirus disease namely COVID-19 is a viral disease induced by severe acute respiratory syndrome coronavirus (SARS-CoV-2). The cases were first reported in Wuhan, China, by the end of 2019 and subsequently spread worldwide. The virus can be transferred through direct or indirect contact and leads to several manifestations; the most common are fever, dry cough, pneumonia, and acute respiratory distress syndrome (ARDS). COVID-19 has caused massive human and economic losses, posing an ongoing threat. Understanding the current situation and developing a treatment which can be both safe and effective has become essential. In this regard, natural products could be an important resource in the development of treatment for COVID-19, as they have contributed to the treatment of other viruses in the past. This review aims to understand the cellular machinery of SARS-CoV-2 and to identify its drug targets. Methods: Emphasis has been given on the literature survey based on in vitro, in vivo, and in silico studies of natural products as anti-SARS-CoV-2. The important role of these compounds in boosting the immune system was also highlighted. Results: It was found that some natural products showed prominent antiviral activity against coronaviruses through impeding the main machinery used in their pathogenesis and replication cycle. Based on in vitro, in vivo, and in silico investigations, several classes of secondary metabolites, particularly polyphenols, have the ability to disrupt the interaction between SARS-CoV-2 S protein and the ACE2 receptor, resulting in virus entry inhibition. As well as the ability to block the activity of several enzymes involved in the virus replication cycle, including, 3CLpro, PLpro and RdRp. On the other hand, several vitamins and minerals can improve the immune response and are useful for COVID-19 prevention. Essential oils also show the ability to disrupt the fluidity of the virus envelope.
Conclusion: Many phytonutrients are counted as bioactive components against SARS-CoV-2, phenolic compounds by their potent mechanisms of action via the immune system rank first. Group B vitamins, vitamins A, C and E as well as minerals such as zinc, selenium and magnesium also play an important role in in preventing the attack by this virus.
ATUAÇÃO DO FARMACEUTICO NA UTILIZAÇÃO DA TOXINA BOTULÍNICA FACIAL
Authors: Santos Roberta da Silva , Andrade Leandro Guimarães de
Published: June 2022

A toxina botulínica é produzida por uma bactéria chamada gram positiva Clostridium botulinum sendo liberada pela lise da  mesma. São resultados dessa lise oito tipos de sorotipos diferentes, como por exemplo, o tipo  A, sendo este o mais utilizado na estética. A toxina botulínica em tratamentos estéticos como opção para a ascensão  de contornos faciais de maneira mais simétrica e sua aplicação pode ser realizada pelo  farmacêutico esteta, sendo este um profissional devidamente habilitado na área. Essa pesquisa teve como objetivo relatar a eficácia da aplicação de toxina botulínica tipo A. Como  procedimento metodológico utilizamos o estudo de revisões bibliográficas. Com o presente estudo foi possível concluir que  o farmacêutico na estética está apto a trabalhar com TBA sendo ele capacitado para tal, sendo responsável pela conduta aplicada.
A IMPORTÂNCIA DA ACURÁCIA NO CONTROLE DE ESTOQUES
Authors: Covic Anderson , Santos Caique Gomes dos , Dias Paulo Henrique dos Santos , Bonini Luci Mendes de Melo , Nunes Samuel Fernandes
Published: June 2022

Estuda-se o processo de gerenciamento de estoques. Este estudo tem como objetivo estudar como os inventários e as novas tecnologias para gerenciamento de estoques podem auxiliar na garantia da acurácia nas informações dos estoques. Trata-se de pesquisa descritiva de abordagem qualitativa. Elaborou-se uma revisão narrativa de literatura e um levantamento de documentos existentes em empresas prestadoras de serviço de gerenciamento de estoques, disponíveis na web. Os resultados mostram que a falta de acurácia traz impactos para diferentes setores da empresa, tais como planejamento, produção, vendas e custos e que entre as soluções para aumentar a acuracidade são: o inventário físico, a metodologia Just-in-time, o Kanban, o Material Requirement Planning (MRP) e o código de barras, este último agiliza a identificação dos produtos e proporciona uma linguagem comum entre as transações sejam nacionais ou internacionais. Concluiu-se que a gestão de estoques vem crescendo em seus aspectos técnicos, práticos e tecnológicos. A tecnologia tem expandido seu olhar para a melhoria da acurácia, principalmente no sentido de desenvolver mecanismos de identificação de mercadorias no nível nacional e internacional, facilitando todos os setores da empresa e minimizando a margem de erro da acurácia.
REABILITAÇÃO VESTIBULAR EM PACIENTES IDOSOS
Authors: Silva Maicon Alves Diniz
Published: June 2022

Selecionou-se este tema onde se observa um grande índice de quedas na população idosa, com elas a taxa de internação e mortalidade se mostram extremamente elevadas. A postura corporal, bem como, o equilíbrio, são grande parte controlados pelo sistema vestibular em conjunto com o sistema visual e o somatossensorial. Os processos da senescência, causam efeitos na agilidade e na qualidade do tempo de respostas fisiológicas no âmbito intrínseco e extrínseco do indivíduo idoso. Contudo, a fim de amenizar os impactos causados pelas quedas na população idosa, a fisioterapia vestibular tem se mostrado promissora no alívio sintomatológico, simultaneamente aumentando a capacidade funcional e a qualidade de vida do indivíduo idoso.
O TRÁFICO DE DROGAS E A MARGINALIZAÇÃO DE ADOLESCENTES: FRONTEIRAS ENTRE SE TORNAR OU SER TORNADO/A MARGINAL
Authors: Quinelatto Rubia Fernanda , Campos Rafael Garcia
Published: June 2022

A presente pesquisa, resultado de uma tese, focaliza o olhar para a trajetória de vida adolescentes, especificamente 14 meninos e 01 menina, em cumprimento de medidas socioeducativas, residentes no interior de São Paulo-SP. Tratam-se de adolescentes marginalizados socialmente que questionam os estereótipos que lhe são impostos ao associar trajetórias de vidas, educação, tráfico de drogas e trabalho. O objetivo geral é compreender quais os significados que eles/a atribuem ao tráfico e o compromisso com a escola. A metodologia utilizada abarcou de modo articulado a História Oral de Vida e a História Oral Temática, destacando fragmentos das histórias dos/a adolescentes que interferem nas escolhas – ou ausência delas – ao longo da vida. As histórias de vida narradas foram transcritas na íntegra, textualizadas e, por fim, transcriadas, conforme decisão metodológica. Como principal resultado e discussão há o escopo de que o tráfico de drogas é entendido como trabalho informal, na visão de adolescentes em conflito com a lei, relatada nesta pesquisa.
DESAFIOS E PERPLEXIDADES NO ATENDIMENTO DE EMERGÊNCIA A QUEM TENTA SUICÍDIO
Authors: Pereira Wilma Suely Batista
Published: June 2022

Pesquisa qualitativa, de campo. Objetivo Geral: Analisar concepções mantidas pelos profissionais sobre o atendimento às pessoas em tentativas de suicídio. Específicos: Elencar sentimentos, opiniões e emoções manifestos pelos participantes em torno do atendimento de pessoas que tentaram suicídio; verificar as experiências narradas pelos participantes em relação atendimentos de pessoas em situação de tentativas e mortes por suicídio; levantar os procedimentos mais frequentemente utilizados nos atendimentos de pessoas que tentaram suicídio. Método: Dados coletados através da técnica “Bola de Neve”, com formulário online e analisadas a partir da Análise de Conteúdo. Resultados: As categorias analíticas foram: 1. Impacto; 2. Dialética dos motivos para tentar morrer; 3. Emergência Ilegítima; 4. O sofrimento de quem atende. Conclusão: ainda há estigmatização em relação à pessoa com comportamento suicida por parte dos profissionais A ausência de psicólogos na atenção básica impacta nos serviços de urgência/emergência. Conhecer as concepções dos profissionais de saúde é importante para a elaboração de políticas públicas de assistência à saúde mental da população, bem como reestruturar os serviços de urgência e emergência, com treinamentos para as equipes.
VIOLÊNCIA DE GÊNERO: INTERVENÇÕES DO SERVIÇO SOCIAL NA GARANTIA DE DIREITO ÀS MULHERES
Authors: Martins Luciana Gonçalves , Honorato Lorena Guimarães Ferreira
Published: June 2022

O presente trabalho expõe acerca da “Violência de gênero: intervenções do Serviço Social na garantia de direito às mulheres". Tem por objetivo identificar os instrumentos de atuação do Serviço Social utilizados na garantia dos direitos das mulheres vítimas de violência de gênero. Além disso, visa esclarecer de que forma a intervenção profissional pode ser utilizada no enfrentamento da violência contra a mulher; identificar ar as políticas públicas voltadas à proteção das vítimas de abuso doméstico e familiar; conhecer as dificuldades da atuação do Assistente Social no combate à violência contra mulher. Utilizou-se como metodologia, a pesquisa bibliográfica em obras e publicações científicas sobre o tema. Verificou-se que a atuação do assistente social neste cenário é de fundamental importância, resgatando esta mulher deste quadro de sofrimento, oferecendo suporte para alcançar seus direitos sociais e jurídicos, através da articulação com os vários segmentos que fazem parte da rede de serviços de apoio à mulher, como as Delegacias Especializadas de Atendimento à Mulher, Polícia Militar, Abrigos e o Centro de Referência Maria do Pará, contribuindo para o empoderamento dessa mulher. Concluiu-se que o assistente social deve ser um profissional que irá mediar e articular esse processo de garantir às mulheres o acesso aos seus direitos, tão violados por seus companheiros, através de uma intervenção que direciona a prevenção e o enfrentamento à violência contra a mulher no Brasil.
A INSERÇÃO DO SERVIÇO SOCIAL NA EDUCAÇÃO BÁSICA: EXPERIÊNCIA DE UMA INSTITUIÇÃO DE ENSINO PRIVADA E FILANTRÓPICA DE SANTARÉM- PARÁ
Authors: Rabelo Beatriz Gomes , Honorato Lorena Guimarães Ferreira , Silva Ivone Domingos e
Published: June 2022

Esse artigo buscou analisar o assistente social inserido em uma instituição de ensino privada e filantrópica do município de Santarém- Pará, seus benefícios e desafios profissionais. Para entender este processo será realizada uma revisão bibliográfica das relações que o permeiam e dos indivíduos envolvidos, como a instituição familiar, que em conjunto com os alunos formam a comunidade escolar, além de um breve histórico acerca da evolução da área educacional. A metodologia de pesquisa abordou aspectos qualitativos e quantitativos, com a abordagem hipotético-dedutiva. Os dados citados no trabalho foram obtidos através de uma entrevista com a profissional de Serviço Social do Colégio Santa Clara, possibilitando identificar o seu perfil, suas principais contribuições e dificuldades, bem como a caracterização do público atendido, as maiores demandas e quantitativo de beneficiados com o programa de assistência estudantil. Tal experiência evidencia a importância e necessidade da presença do assistente social na escola, sendo uma das ferramentas que implicam diretamente no desenvolvimento do estudante.
AMBIENTES VIRTUAIS DE APRENDIZAGEM - CONCEPÇÕES DA LINGUÍSTICA, MULTILETRAMENTOS E MEMÉTICA: UMA PESQUISA EXPERIMENTAL
Authors: Moraes Isabella Tavares Sozza
Published: June 2022

Neste artigo, apresentamos as concepções a respeito dos ambientes virtuais de aprendizagem por óticas multidisciplinares. Sendo assim, questiona-se: como podemos possuir aprendizagem significativa por meio dos AVAs? Temos como hipótese a utilização dos AVAs e TDICs como meios de aprendizagem significativa, por meio de multiletramentos e gamificações.Temos como objetivos específicos: (i) verificar a importância dos AVAs; (ii) descrever as associações entre a linguística, educação e tecnologia nos AVAs como objetos principais deste estudo e (iii) implementar por meio das teorias estudadas, um AVA contextualizado. O corpus selecionado para este estudo, na área da linguística, foram recortes de interações verbais por meio dos AVAs, de forma polida e impolida. O que justifica a escolha do tema é o fato de atualmente haver o uso contante de TDICs, principalmente no contexto pandêmico. O arcabouço teórico que sustenta este trabalho são os estudos sobre Pragmática e Sociolinguística interacional de Brown & Levinson (1987),  Cabral & Albert (2017), Goffman (1967), Kerbrat-orecchioni (2005) e Spencer-Oatey (2000). Estudos sobre os AVAs de Moran (2002), Mondim (2013), Milligan (1999). Estudos sobre os multiletramentos de Cazden; Cope; Fairclogh et al (1996), Rojo (2008; 2010; 2013; 2017; 2021). Estudos sobre linguística e Filosofia da linguagem de Marchuschi (2008) e Barthes (1984). A metodologia utilizada na pesquisa é tipológica - Marinho e Vasconcelos (2011) -, sua abordagem é qualitativa, de natureza aplicada, de objetivo exploratório. Utilizou-se os procedimentos técnicos - bibliográfico e experimental. Os resultados alcançados confirmam que é preciso possuir o cuidado com a interação verbal e realçar conhecimentos significativos, por meio dos AVAs. Dessa forma, evidenciamos que os ambientes virtuais de aprendizagem visam a integração do conhecimento por meio da virtualização, por isso, as trocas conversacionais devem possuir o respeito à hierarquia e a interação visada sem ataque à face do outro.