bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanism of Infrared-Laser Engraving for Polycarbonate-Based Films
Authors: Gu Xi Guang , Qian Bin , Yu Li Yin , Wang Jun Hua , Wang Yuan Zhen
Published: July 2020

The work aim to the reaction mechanism of laser engraving polycarbonate (PC)-based films. The calculation of infrared-laser acting on the PC films, was carried out by using one-dimensional heat conduction model. The power density of laser device required for laser engraving polycarbonate-based films was determined to be 4.86~7.73×104 W/cm2. Characterized by the FTIR spectra, SEM, DSC and TGA, the reaction mechanism was studied. The results show that the light-sensitive particles in the PC films absorb the laser energy with wavelength of 1064nm. After reaching the temperature of 509°C, the main chain of PC molecule opened due to the breakage of C-O bond in PC molecular terminal group and C-O bond between PC monomers. As the energy continues to be absorbed, the temperature reach to 610°C, the decomposition products decomposed into carbon black, which can form a black carbon spot.
Lumen Maintenance of Ternary Ag-Alloy Wire Bonded LED Package after Reliability Tests
Authors: Yuan Jui Hung , Chuang Tung Han , Chuang Ju Hui
Published: July 2020

In this investigation, ternary Ag-alloy wires were doped with different Pd and Au concentrations, and each wire was encapsulated in an LED package. The static and dynamic reliability were tested, and the lumen maintenance performance was examined. The static reliability tests included the sulfur test, LTSL, HTSL, and WHTSL. According to the sulfur test data, higher Pd and Au contents led to better lumen maintenance. Furthermore, the bonding wire of the LED with better lumen maintenance in the sulfur test had higher electrical resistance. The brightness decay rate of the white light LEDs was low in low-and high-temperature environments, but it was significantly higher after the WHTSL test. The dynamic reliability test after 1,000 hours of HTOL and WHTOL showed that the lumen maintenance improved with higher Pd and Au contents, indicating that doping Ag-alloy wires with sufficient amounts of Pd and Au can retard degradation due to thermal and humidity aging and oxidation reaction. Therefore, ternary Ag-Pd-Au alloy wires produced with specific drawing and annealing processes are suitable for application to mid-power white light LEDs.
Study on the Precipitation Behavior of Precipitates of 7075 Aluminum Alloy Friction Stir Welding Joint
Authors: Zhu Hao , Dong Shao Kang , Ma Ze Ming , Wang Jun
Published: July 2020

In this work, the microhardness of 7075 aluminum alloy friction stir welding (FSW) joint was measured by a micro vickers hardness tester, the microstructure of the joints was characterised by microscope, the precipitated phases among the welding nugget zone (WNZ), thermal mechanical affected zone (TMAZ), heat affected zone (HAZ) were affirmed by X-ray diffractometer (XRD) and the lattice fringe of transmission electron microscopy (TEM) high resolution image. Based on this, the precipition behavior of precipitated phases was studied. The results show that the microhardness distribution of the 7075 aluminium alloy FSW joints is heterogeneous in comparison with the base metal (BM). The precipitates in the joint mainly include MgZn rod shape and AlCuMg in elliptical shape. In the WNZ, the main precipitate is AlCuMg, and the fine grain strengthening effect is better, so the microhardness in this zone is relatively high. In the TMAZ, the quantity of AlCuMg decreased while the MgZn2 increased relatively in comparison with the WNZ. At the same time, the effect of the fine grain strengthening was weakened, though the strain hardening increased. Therefore, the microhardness in the TMAZ still decreased. In the HAZ, the quantity of MgZn2 increased furtherly, and there is no strain hardening and fine grain strengthening, so the microhardness of the HAZ was the lowest among the FSW joints. Besides, through comparative tests, the optimal process parameters of friction stir welding of 7075 aluminum alloy were obtained.
The effect of inter-personal trusts on transaction costs of owner-managed small enterprises in Sri Lanka
Authors: Priyanath H. M. S. , Premaratne S. P.
Published: July 2020

The study explores how inter-personal trusts between the Owners of Small Enterprises (OSEs) and their exchange partners affect the mitigation of Transaction Costs (TC) of Small Enterprises (SEs) in Sri Lanka. Data were collected from 373 SEs located in nine Districts representing all Provinces in Sri Lanka, by conducting face to face personal interviews with the respondents. The data were analyzed using Partial Least Squares-Structural Equation Modelling. Results revealed that inter-personal trust between the OSEs and exchange partners has negatively affected firm TC, providing sufficient evidence to conclude that inter-personal trust has a significant impact on mitigating TC of SEs and providing important insights for policy makers to focus their strategies on new direction on focus their strategies conventional approaches to support SEs.
Volatility spillovers between south Asian stock markets: evidence from Sri Lanka, India and Pakistan
Authors: Withanage Yeshan , Jayasinghe Prabhath
Published: July 2020

This study examines the existence, magnitude and direction of volatility spillovers between the Sri Lankan stock market and two other major stock markets in the South Asian region: India and Pakistan. Main stock indices of Sri Lanka, India, and Pakistan are employed as proxies to represent stock markets of each country. Daily data over the period 2nd January 2004 to 23rd September 2014 is used for estimations. Volatility spillovers are modeled through a trivariate BEKK – GARCH (1, 1) model to capture the cross-market effects. There exist bilateral intraday volatility spillovers between Sri Lanka and both markets. It is evident that the intraday effect from Pakistan to Sri Lanka is stronger than the same effect from India to Sri Lanka. However, with respect to overnight volatility spillovers, there is only a unilateral spillover effect from Sri Lanka to India. Evidence for the presence of volatility spillovers between these three South Asian economies makes the tasks of monetary policy makers, investors and fund managers more complicated than they would otherwise have been.
Myeloid Cell–Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions
Authors: Yan Jie , Hedl Matija , Abraham Clara
Published: July 2020

Common IRF5 genetic risk variants associated with multiple immune-mediated diseases are a major determinant of interindividual variability in pattern-recognition receptor (PRR)–induced cytokines in myeloid cells. However, how myeloid cell–intrinsic IRF5 regulates the multiple distinct checkpoints mediating T cell outcomes in vivo and IRF5-dependent mechanisms contributing to these distinct checkpoints are not well defined. Using an in vivo Ag-specific adoptive T cell transfer approach into Irf5−/− mice, we found that T cell–extrinsic IRF5 regulated T cell outcomes at multiple critical checkpoints, including chemokine-mediated T cell trafficking into lymph nodes and PDK1-dependent soluble Ag uptake, costimulatory molecule upregulation, and secretion of Th1 (IL-12)– and Th17 (IL-23, IL-1β, and IL-6)–conditioning cytokines by myeloid cells, which then cross-regulated Th2 and regulatory T cells. IRF5 was required for PRR-induced MAPK and NF-κB activation, which, in turn, regulated these key outcomes in myeloid cells. Importantly, mice with IRF5 deleted from myeloid cells demonstrated T cell outcomes similar to those observed in Irf5−/− mice. Complementation of IL-12 and IL-23 was able to restore T cell differentiation both in vitro and in vivo in the context of myeloid cell–deficient IRF5. Finally, human monocyte-derived dendritic cells from IRF5 disease-associated genetic risk carriers leading to increased IRF5 expression demonstrated increased Ag uptake and increased PRR-induced costimulatory molecule expression and chemokine and cytokine secretion compared with monocyte-derived dendritic cells from low-expressing IRF5 genetic variant carriers. These data establish that myeloid cell–intrinsic IRF5 regulates multiple distinct checkpoints in T cell activation and differentiation and that these are modulated by IRF5 disease risk variants.
Osteal Tissue Macrophages Are Involved in Endplate Osteosclerosis through the OSM-STAT3/YAP1 Signaling Axis in Modic Changes
Authors: Wang Jiasheng , Zheng Zeyu , Huang Bao , Wu Hao , Zhang Xuyang , Chen Yilei , Liu Junhui , Shan Zhi , Fan Shunwu , Chen Jian , Zhao Fengdong
Published: July 2020

Modic changes (MCs) are radiographic manifestations of lumbar degenerative diseases. Various types of MCs are often associated with endplate osteosclerosis. Osteal tissue macrophages (Osteomacs) were reported to be crucial for bone homeostasis and bone repair, but whether osteomacs participate in the endplate osteosclerosis in MCs remained unclear. In this study, we tried to explore the critical role of osteomacs in regulating osteogenesis in MCs. We collected MCs from patient samples and developed a Propionibacterium acnes–induced rat MCs model, using microcomputed tomography and immunohistochemistry to detect the endplate bone mass and distribution of osteomacs. In patients' MCs, osteomacs increased in endplate subchondral bone, especially in Modic type II. Endplate in Modic type III presented a stable osteosclerosis. In rat MCs model, osteomacs increased in the bone hyperplasia area but not in the inflammation area of the endplate region, whereas the distribution of osteomacs was consistent with the area of osteosclerosis. To further explore the functions of osteomacs in vitro, we isolated osteomacs using MACS technology and found osteomacs secreted oncostatin M (OSM) and strongly promoted osteoblast differentiation rather than osteoclast through the mechanism of OSM-mediated tyrosine phosphorylation and interaction of STAT3 and Yes-associated protein 1 (YAP1). STAT3 phosphorylation inhibition or YAP1 knockdown attenuated OSM-mediated osteoblast differentiation. Finally, we confirmed that blockade of OSM in vivo using anti-OSM–neutralizing Ab prevented endplate osteosclerosis in rat MCs model. Taken together, these findings confirmed that endplate osteosclerosis in MCs was accompanied by an increased number of osteomacs, which regulated osteogenesis via the OSM-STAT3/YAP1 signaling axis.
IFNs Drive Development of Novel IL-15–Responsive Macrophages
Authors: Gordon Scott M. , Nishiguchi Mailyn A. , Chase Julie M. , Mani Sneha , Mainigi Monica A. , Behrens Edward M.
Published: July 2020

Disruption in homeostasis of IL-15 is linked to poor maternal and fetal outcomes during pregnancy. The only cells described to respond to IL-15 at the early maternal–fetal interface have been NK cells. We now show a novel population of macrophages, evident in several organs but enriched in the uterus of mice and humans, expressing the β-chain of the IL-15R complex (CD122) and responding to IL-15. CD122+ macrophages (CD122+Macs) are morphologic, phenotypic, and transcriptomic macrophages that can derive from bone marrow monocytes. CD122+Macs develop in the uterus and placenta with kinetics that mirror IFN activity at the maternal–fetal interface. M-CSF permits macrophages to express CD122, and IFNs are sufficient to drive expression of CD122 on macrophages. Neither type I nor type II IFNs are required to generate CD122+Macs, however. In response to IL-15, CD122+Macs activate the ERK signaling cascade and enhance production of proinflammatory cytokines after stimulation with the TLR9 agonist CpG. Finally, we provide evidence of human cells that phenocopy murine CD122+Macs in secretory phase endometrium during the implantation window and in first-trimester uterine decidua. Our data support a model wherein IFNs local to the maternal–fetal interface direct novel IL-15–responsive macrophages with the potential to mediate IL-15 signals critical for optimal outcomes of pregnancy.
NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy
Authors: Ogawa Tatsuya , Ishitsuka Yosuke , Nakamura Yoshiyuki , Kubota Noriko , Saito Akimasa , Fujisawa Yasuhiro , Watanabe Rei , Okiyama Naoko , Suga Yasushi , Roop Dennis R. , Fujimoto Manabu
Published: July 2020

Atopic dermatitis is a chronic form of allergic contact dermatitis that is closely associated with a compromised epidermal barrier. Immunogenicity of a given electrophilic hapten after penetration of this barrier depends directly on biochemical reactions in the thiol-rich layer in the stratum granulosum. In response to electrophilic hapten, NF-erythroid 2–related factor 2 (NRF2) in keratinocytes efficiently induces the production of antioxidants. In this study, we show that the immunogenicity of a given hapten depends directly on the extent to which it induces antioxidant host defenses within the epidermal tissue. We found that allergic contact dermatitis did not develop in NRF2-deficient mice because of compromise of the epidermal innate immune responses that upregulate IL-1α. We also analyzed epidermal NRF2 in association with congenital disorders with features similar to atopic dermatitis in humans. Epidermal samples from patients with Netherton syndrome and peeling skin syndrome exhibited elevated levels of NRF2 and also elevated levels of its downstream target, small proline-rich protein 2. Taken together, these results suggest that the thiol-mediated biochemical responses in the stratum granulosum provide a critical link between defective epidermal barrier function and the development of atopy. Likewise, our results suggested that NRF2 may have a profound impact on the generation of cutaneous immunological memory.
Long Noncoding RNA AW112010 Promotes the Differentiation of Inflammatory T Cells by Suppressing IL-10 Expression through Histone Demethylation
Authors: Yang Xiaoming , Bam Marpe , Becker William , Nagarkatti Prakash S. , Nagarkatti Mitzi
Published: July 2020

Long noncoding RNAs (lncRNAs) have been demonstrated to play important regulatory roles in gene expression, from histone modification to protein stability. However, the functions of most identified lncRNAs are not known. In this study, we investigated the role of an lncRNA called AW112010. The expression of AW112010 was significantly increased in CD4+ T cells from C57BL/6J mice activated in vivo with myelin oligodendrocyte glycoprotein, Staphylococcal enterotoxin B, or in vitro with anti-CD3 anti-CD28 mAbs, thereby demonstrating that activation of T cells leads to induction of AW112010. In contrast, anti-inflammatory cannabinoids such as cannabidiol or δ-9-tetrahydrocannabinol decreased the expression of AW112010 in T cells. Interestingly, the expression of AW112010 was high in in vitro–polarized Th1 and Th17 cells but low in Th2 cells, suggesting that this lncRNA may regulate inflammation. To identify genes that might be regulated by AW112010, we used chromatin isolation by RNA purification, followed by sequencing. This approach demonstrated that AW112010 regulated the transcription of IL-10. Additionally, the level of IL-10 in activated T cells was low when the expression of AW112010 was increased. Use of small interfering RNA to knock down AW112010 expression in activated T cells led to increased IL-10 expression and a decrease in the expression of IFN-γ. Further studies showed that AW112010 interacted with histone demethylase KDM5A, which led to decreased H3K4 methylation in IL-10 gene locus. Together, these studies demonstrate that lncRNA AW112010 promotes the differentiation of inflammatory T cells by suppressing IL-10 expression through histone demethylation.
Human Hepatitis B Viral Infection Outcomes Are Linked to Naturally Occurring Variants of HLA-DOA That Have Altered Function
Authors: Graves Austin M. , Virdis Francesca , Morrison Eliot , Álvaro-Benito Miguel , Khan Aly A. , Freund Christian , Golovkina Tatyana V. , Denzin Lisa K.
Published: July 2020

HLA molecules of the MHC class II (MHCII) bind and present pathogen-derived peptides for CD4 T cell activation. Peptide loading of MHCII in the endosomes of cells is controlled by the interplay of the nonclassical MHCII molecules, HLA-DM (DM) and HLA-DO (DO). DM catalyzes peptide loading, whereas DO, an MHCII substrate mimic, prevents DM from interacting with MHCII, resulting in an altered MHCII–peptide repertoire and increased MHCII–CLIP. Although the two genes encoding DO (DOA and DOB) are considered nonpolymorphic, there are rare natural variants. Our previous work identified DOB variants that altered DO function. In this study, we show that natural variation in the DOA gene also impacts DO function. Using the 1000 Genomes Project database, we show that ∼98% of individuals express the canonical DOA*0101 allele, and the remaining individuals mostly express DOA*0102, which we found was a gain-of-function allele. Analysis of 25 natural occurring DOα variants, which included the common alleles, identified three null variants and one variant with reduced and nine with increased ability to modulate DM activity. Unexpectedly, several of the variants produced reduced DO protein levels yet efficiently inhibited DM activity. Finally, analysis of associated single-nucleotide polymorphisms genetically linked the DOA*0102 common allele, a gain-of-function variant, with human hepatitis B viral persistence. In contrast, we found that the DOα F114L null allele was linked with viral clearance. Collectively, these studies show that natural variation occurring in the human DOA gene impacts DO function and can be linked to specific outcomes of viral infections.
Estimation and analysis of the effective rainfall In Tabuk area – Saudi Arabia
Authors: د. فهدة فلاح بن حشر د. فهدة فلاح بن حشر
Published: July 2020

this study examined the effective rainfall in Tabuk area by applying the Lang rainfall factor, De Martonne Index and the (UNEP) arid index. The study methodology was based on a statistical tests using the Normality test (Shapiro-Wilk), the Homogeneity test (Leven test), the ANOVA (LSD test) of the monthly mean of rainfall, the daily maximum rainfall and the total number of rainfall days. The multiple comparison (Tehmane’s Test) had been applied between the studied stations. The results of the Shapiro-Wilk test shows that the distribution of monthly rainfall averages follows normal distribution in all stations except stations Tabuk and Al Bad’ and that the maximum daily rainfall distribution at Duba, Shuw?q, Al Kurr stations is also normal distribution. The Leven test results showed that the significance level was greater than 0.05 and the Leven Test was greater than 0.05 for the average monthly precipitation, for the daily maximum rainfall and for the number of rain days and it indicates the homogeneity of the rainfall variances in the studied stations.The ANOVA analysis of the averages and maximum daily rainfall, shows that the significance level is greater than 0.05 and the LSD test is greater than 0.05 indicating that the differences are not significant. While the LSD was greater than 0.05 for the number of rain days, indicating that the differences between the number of rain days and their distribution at the studied stations are statistically significant differences, and therefore there is no homogeneity in their differences. The results of the Tamhane’s Test of multiple comparison confirmed that the mean level of monthly mean rainfall and daily maximum rainfall is greater than 0.05 indicates that the differences between the monthly rain averages of and the daily maximum rainfall amounts are not significant for 22.2% of total comparisons.The effective rainfall estimate of Lang’s rainfall index shows that the threshold of effective mean rainfall is between 1.3 and 27.4 mm and that the threshold of maximum daily rainfall is 154.1 mm at the station (Al Bad’). Also, the effective rainfall estimate by the DeMartonne index shows that the threshold of average effective rainfall is between 1.2 and 15.2 mm and that the threshold of maximum daily rainfall is 80.4 mm at the station (Al Bad’). Therefore, the effective rainfall estimate by the UNEP index shows that the threshold of average effective rainfall is between 1.8 and 30.3 mm and that the threshold of maximum daily rainfall is 130.5 mm at the station (Al Bad’). Finally, the effective rainfall estimate by the difference between the rainfall and Pan Class“A” Evaporation shows that the threshold of average effective rainfall is between 1.2 and 25.8 mm and that the threshold of maximum daily rainfall is 137.1 mm at the station (Al Bad’).- Key Words:Effective rainfall average, Effective maximum daily rainfall , Number of rainy days, Statistical tests, Lang rainfall factor, DeMartonne index, UNEP arid index, Tabuk area, Saudi Arabia.
General Supervisor at the National Institute for Educational Professional Development (NIEPD)
Authors: د. إلهام إبراهيم فوزان الفوزان د. إلهام إبراهيم فوزان الفوزان
Published: July 2020

this study aimed to recognize the reality of the re-engineering of administrative processes in the offices of education In Riyadh city and the obstacles which prevent their real application and to find statistically significant differences between the average responses of the sample of the study . The researchers used the descriptive survey approach in their study and applied the study to all the directors and assistants of the offices of education for girls in Riyadh, and a random sample of the heads of units and educational supervisors. The number of members of the sample of the study were (236) from the original society. The researchers used the questionnaire as the tool of collecting data. The study had a number of results which were: The reality of re-engineering administrative processes in the dimensions (planning, organization, guidance, control) achieved to a medium degree with the arithmetic mean at (2.85), and the obstacles to the re-engineering of administrative processes achieved to a high degree with the arithmetic mean at (3.81), there were no statistically significant differences between the responses of the sample study to the reality of re-engineering administrative processes and the obstacles that limit their application due to the different scientific qualifications but there were statistically significant differences between the responses of the sample study to the re-engineering of administrative processes and the obstacles that limit their application due to different job and years of experience.
Effect of Entada africana Guill. er Perr. (Mimosaceae) extracts on some symptoms of estrogen deficiency in ovariectomized Wistar rats
Authors: Mvondo Marie Alfrede , Saah Namekong Harding , Minko Essono Stéphane , Awounfack Charline Florence , Njamen Dieudonné
Published: July 2020

No Abstract.
Study on establishing a mining group of deposit and an exploration grid pattern for lead - zinc ore in Ban Lim area, Cao Bang province
Authors: Luong Khang Quang , Khuong Hung The , Nguyen Tuong Van , Le Thu Thi ,   Faculty of Geosciences and Geoengineering, Hanoi University of Mining and Geology, Vietnam
 Dong Bac Geological Division, Cach Mang Thang Tam road, Thai Nguyen City, Thai Nguyen, Vietnam
Published: July 2020

Ban Lim area in Cao Bang province has proposed a high potential of lead-zinc resources, which have occurred in different rocks of geological formation. The paper-based on collecting, synthesizing, and geological processing data. In addition, mathematical methods were also applied to recognize studied objects of the exploration process using a quantitative description. The results how that the lead-zinc orebodies in Ban Lim area mainly occurred in lens-shaped and distributed in layered surfaces of the dolomitized limestone of Coc Xo formation. The average lead-zinc content of the orebodies is in a range from 3.27% to 8.33%; its coefficient of variation (Vc) is in a range from 13.71% (evenly) to 137.92% (very unevenly). Generally, the lead-zinc contents of the orebodies in Ban Lim area mainly comply with the standard normal distribution. The average thicknesses of the orebodies are in a range from 0.92 m to 6.48 m, its coefficient of variation (Vm) is in the range from 8.7% (stable) to 132.95% (very unstable). Quantitative calculation results have shown that Ban Lim lead-zinc deposit belongs to group III of deposits. For the exploration of this type of minerals, it is recommended to use a linear grid pattern. Appropriate exploration grid pattern for the 122 category reserve is (60÷80) m × (30÷40) m. These calculated results are well- documented foundations that allow suggesting a mining group of deposit and an exploration grid pattern for lead-zinc ore in Ban Lim area and other lead-zinc deposits occurring in similar geological settings.
A 2-D numerical model of the mechanical behavior of the textile-reinforced concrete composite material: effect of textile reinforcement ratio
Authors: Tran Tien Manh , Do Tu Ngoc , Dinh Ha Thu Thi , Vu Hong Xuan , Ferrier Emmanuel ,   Department of Mechanisms of Materials, Hanoi University of Mining and Geology, Vietnam
 Université de LYON, Université Claude Bernard LYON ; Laboratoire des Matériaux Composites pour la Construction LMC, France
Published: July 2020

The textile-reinforced concrete composite material (TRC) consists of a mortar/concrete matrix and reinforced by multi-axial textiles (carbon fiber, glass fiber, basalt fiber, etc.). This material has been used widely and increasingly to reinforce and/or strengthen the structural elements of old civil engineering structures thanks to its advantages. This paper presents a numerical approach at the mesoscale for the mechanical behavior of TRC composite under tensile loading. A 2-D finite element model was constructed in ANSYS MECHANICAL software by using the codes. The experimental results on basalt TRC composite from the literature were used as input data in the numerical model. As numerical results, the basalt TRC provides a strain-hardening behavior with three phases, depending on the number of basalt textile layers. In comparison with the experimental results, it could be found an interesting agreement between both results. A parametric study shows the significant influence of the reinforcement ratio on the ultimate strength of the TRC composite. The successful finite element modeling of TRC specimens provides an economical and alternative solution to expensive experimental investigations.
El Patronato de san Isidoro sobre la ciudad de Sevilla y su archidiócesis. Una aproximación histórica y devocional
Authors: Gámez Martín José
Published: July 2020

A petición del cardenal De la Lastra en 1868 el beato Pío IX firmó un breve pontificio por el que se nombraba a san Isidoro Patrón de la ciudad de Sevilla, llegando así el Doctor de las Españas al lugar que le correspondía como una de las figuras más señeras e importantes del catolicismo hispano. Su celebración litúrgica tiene el rango de solemnidad cada 26 de abril y sigue viva su devoción en los muros de la catedral hispalense. Casi un siglo después fue Pío XII mediante la bula Quam Fervida del 15 de agosto de 1946 el que nombra a Nuestra Señora de los Reyes Patrona Principal de la ciudad y archidiócesis por el ferviente deseo de toda Sevilla representada en su pastor el cardenal Segura.
A vueltas con lo de siempre: deporte y modo de vida
Authors: Puig Nuria
Published: July 2020

El presente artículo forma parte de la sección de debate "Deporte y COVID-19" del Volumen 1, Número 1, de Sociología del Deporte (SD).
Ejercicio físico en tiempos de aislamiento social
Authors: Mateu Pau , Rodrigues Marques Renato Francisco
Published: July 2020

Desde su reciente aparición y su rápida difusión mundial, la pandemia de la COVID-19 ha derivado en una crisis sanitaria y social sin precedentes. Millones de personas han visto interrumpidas sus vidas cotidianas y han tenido que confinarse durante varias semanas con el objetivo de reducir la curva de contagios e impedir el colapso de los sistemas sanitarios. Conscientes de los riesgos para la salud física y mental que se derivan de la vida sedentaria, los poderes públicos han tratado de fomentar un estilo de vida activo mediante la realización de ejercicio físico en el hogar. A partir de algunas de las categorías sociológicas establecidas por Pierre Bourdieu, este artículo reflexivo se propone discutir la realización (o no), por parte de diferentes sectores poblacionales, de ejercicio físico en el hogar en el actual contexto de confinamiento domiciliario. Nuestra posición es que, en las estructuras sociales desiguales, típicas de los Estados neoliberales, los sectores más desfavorecidos no pueden ni siquiera plantearse realizar ejercicio físico. Las estrategias que se centran en la motivación individual no solo no pueden ser efectivas, sino que, además, culpabilizan a quienes no poseen capitales ni disposiciones para entrenar en sus hogares.
Redes sociales en tiempos del COVID-19
Authors: Joaquín Piedra
Published: July 2020

El presente artículo forma parte de la sección de debate "Deporte y COVID-19" del Volumen 1, Número 1, de Sociología del Deporte (SD).
El contexto del deporte en España durante la crisis sanitaria de la COVID-19
Authors: Moscoso-Sánchez David
Published: July 2020

El presente artículo forma parte de la sección de debate "Deporte y COVID-19" del Volumen 1, Número 1, de Sociología del Deporte (SD).
Educación física post COVID-19 ¿Evolución o deriva?
Authors: Martínez Egea Bienvenido
Published: July 2020

El presente artículo forma parte de la sección de debate "Deporte y COVID-19" del Volumen 1, Número 1, de Sociología del Deporte (SD).
Covid-19, Exercise and bodily self-control
Authors: Malcolm Dominic , Velija Philippa
Published: July 2020

This article is part of the discussion section "Sport and COVID-19" of Volume 1, Number 1, of Sports Sociology (SD).
Chẩn đoán đột biến di truyền đơn gen giai đoạn phôi tiền làm tổ (PGT-M) trong loại trừ gen bệnh thalassemia: báo cáo loạt ca
Authors: Dang Quang Vinh , Nguyen Minh Tuan , Luu Thi Minh Tam , Pham Thieu Quan , Tran Tu Cam , Huynh Gia Bao , Ho Manh Tuong
Published: July 2020

Đặt vấn đề: Thiếu máu tán huyết di truyền (thalassemia) là một bệnh lý huyết học đơn gen. Bệnh nhân cần được điều trị suốt đời và có thể tử vong nếu không tuân thủ điều trị Tại Việt Nam, ước tính hiện nay có khoảng 20.000 người bị thalassemia thể nặng, mỗi năm có thêm khoảng 10 triệu người mang gen bệnh và hàng năm, có thêm trên 2.000 trẻ bị bệnh thalassemia chào đời. Kỹ thuật chẩn đoán đột biến di truyền đơn gen giai đoạn phôi tiền làm tổ (Preimplantation Genetic Testing for Monogenic disorders - PGT-M) ra đời, cho phép các cặp vợ chồng sau khi có phôi từ thụ tinh trong ống nghiệm (TTTON), lựa chọn những phôi không có đột biến gen gây bệnh để chuyển vào buồng tử cung người vợ giúp có thể sinh con không mang bệnh.

Mục tiêu: Đánh giá hiệu quả của chuyển phôi sau PGT-M trên bệnh nhân vô sinh mang gen bệnh thalassemia.

Phương pháp: Đây là một báo cáo loạt ca, thực hiện trong thời gian từ tháng 02/2017 đến tháng 05/2018 tại Đơn vị Hỗ trợ sinh sản Mỹ Đức (IVFMD), bệnh viện Mỹ Đức. Đối tượng bệnh nhân là những cặp vợ chồng có chỉ định làm TTTON và quá trình sàng lọc cho thấy cả hai có mang gen bệnh. Phôi ngày 5, hình thành sau TTTON, được tiến hành sinh thiết để lấy khoảng 5 tế bào lá nuôi. Các tế bào được gửi phân tích di truyền bằng công nghệ giải trình tự thế hệ mới (Next Generation Sequencing – NGS) qua hai giai đoạn, (1) xác định tình trạng lệch bội và (2) chẩn đoán bất thường đơn gen trên các phôi không lệch bội. Phôi được đông lạnh sau khi sinh thiết và những phôi nào không mang gen bệnh hay ở dạng dị hợp tử mới được sử dụng để chuyển vào buồng tử cung của người vợ. Yếu tố đánh giá kết quả chính là tỷ lệ sinh sống sau một chu kỳ chuyển phôi.

Kết quả: Trong thời gian nghiên cứu, có 17 cặp bệnh nhân thỏa tiêu chuẩn nhận loại. Số noãn chọc hút trung bình là 16,7 ± 8,5, với số phôi ngày 5 trung bình là 6,8 ± 4,6. Trong số 79 phôi được sinh thiết, có 50 (63,3%) phôi không bị lệch bội. Trong 50 phôi này, tỷ lệ phôi không mang gen đột biến hay ở dạng dị hợp tử lần lượt là 36% và 56%. Hiện có 7 trường hợp sinh sống được ghi nhận và 1 trường hợp có thai đang ở tuổi thai 33 4/7 tuần.

Kết luận: PGT-M có thể được áp dụng thường quy trên các cặp vợ chồng có mang gen gây bệnh thalassemia nhằm giúp có thể sinh con từ những phôi không mang gen bệnh, hạn chế các gánh nặng về kinh tế, tâm lý cho gia đình và xã hội.
Chẩn đoán trước sinh bệnh loạn dưỡng cơ Duchenne cho các thai phụ mang gen đột biến dị hợp tử bắt buộc bằng kỳ thuật Microsatellite
Authors: Dinh Thuy Linh , Tran Van Khanh , Tran Huy Thinh , Nguyen Duc Hinh
Published: July 2020

Loạn dưỡng cơ Duchenne (DMD) là bệnh lý di truyền thần kinh cơ hay gặp nhất trong nhóm bệnh lý loạn dưỡng cơ với tần suất 1/3500 trẻ trai. DMD là bệnh di truyền liên kết nhiễm sắc thể giới tính X, do đột biến gen Dystrophin. Do hiện nay chưa có phương pháp điều trị đặc hiệu, nên chẩn đoán trước sinh các trường hợp thai phụ là người mang gen bệnh sẽ giúp phát hiện các trường hợp thai mắc DMD, giảm tỷ lệ mắc bệnh trong cộng đồng. Mục tiêu: Mô tả kết quả chẩn đoán trước sinh bệnh DMD ở các thai phụ mang gen dị hợp tử bắt buộc bằng kỹ thuật Microsatellite. Phương pháp nghiên cứu: 12 thai phụ mang thai từ 17-22 tuần, được xác định là mang gen đột biến dị hợp tử bắt buộc; Sử dụng kỹ thuật Microsatellite chẩn đoán trước sinh bệnh DMD. Kết quả: 4/12 thai nhi được chẩn đoán là thai nhi bệnh lý, thai phụ đã được tư vấn và quyết định đình chỉ thai nghén. 8/12 thai nhi được chẩn đoán là bình thường, tiếp tục theo dõi thai kỳ. Kết luận: ứng dụng thành công các kỹ thuật Microsatellite trong chẩn đoán trước sinh bệnh DMD cho các thai phụ mang đột biến dị hợp tử bắt buộc.
Phân tích đột biến C677T và A1298C của gen MTHFR ở phụ nữ có tiền sử sẩy thai, thai chết lưu
Authors: Trinh Thi Que , Doan Thi Kim Phuong , Ta Thanh Van , Duong Thi Thu Hien , Hoang Thi Ngoc Lan , Pham Ba Nha
Published: July 2020

Mục tiêu: Đánh giá mối liên quan giữa kiểu gen MTHFR C677T và A1298C với tình trạng sảy thai, thai chết lưu. Đối tượng và phương pháp: Nghiên cứu bệnh chứng 118 người trong đó 35 người nhóm chứng và 83 người nhóm có sảy thai, thai chết lưu ít nhất 2 lần. Xác định kiểu gen MTHFR C677T và A1298C của nhóm nghiên cứu bằng kỹ thuật Realtime PCR. Kết quả: Tỷ lệ đột biển của MTHFR C677T lần lượt là 43,4% và 31,4% trong nhóm bệnh và nhóm chứng. Tỷ lệ đột biến của MTHFR A1298C trong nhóm bệnh và nhóm chứng lần lượt là 53% và 34,3%. Tổ hợp của 2 đột biến MTHFR C677T và A1298C ỏ nhóm bệnh cao hơn đáng kể so với nhóm chứng với p
Nghiên cứu các đặc điểm siêu âm và kết quả xử trí thai kỳ song thai một bánh nhau tại Bệnh viện Phụ sản Nhi Đà Nẵng
Authors: Ha Thi Tieu Di , Vo Ta Son , Le Duc Vinh
Published: July 2020

Mục tiêu: Nghiên cứu các đặc điểm siêu âm song thai một bánh nhau và kết quả xử trí.

Đối tượng và phương pháp nghiên cứu: Gồm 61 thai phụ được chẩn đoán song thai một bánh nhau từ tháng 8/2018 đến 3/2019 tại Bệnh viện Phụ sản - Nhi Đà Nẵng, được nghiên cứu cắt ngang mô tả và hồi cứu.

Kết quả: Thai phụ 25 - 34 tuổi tỉ lệ cao nhất 78,7%, trung bình 28,3 ± 4,2 tuổi. Nhóm thai phụ Đà Nẵng chiếm 50,8% và ngoại tỉnh 49,2%. Thai phụ là công nhân viên tỉ lệ cao nhất 36,0% (p > 0,05). Bản thân và gia đình không có tiền sử sinh song thai tỉ lệ 83,5%. Tất cả thai phụ phát hiện song thai một bánh nhau trong quí I. 8,2% trường hợp siêu âm 3 tháng đầu có chênh lệch khoảng mờ gáy (> bách phân vị 95) và chiều dài đầu - mông thai nhi. Song thai một nhau - hai ối chiếm 95,1%. Thai chậm tăng trưởng chọn lọc (sIUGR) chiếm tỉ lệ cao nhất 41%, type I:34,5%; hội chứng truyền máu cho nhận (TTTS) 11,5%. Chúng tôi giảm ối 3/7 trường hợp TTTS; 37,7% sIUGR được theo dõi đến lúc sinh, can thiệp bào thai: 1 trường hợp đốt laser (TTTS), 3 trường hợp hủy thai chọn lọc (3 TTTS kèm 2 sIUGR,). Tuổi thai lúc sinh 32 - 36 tuần tỉ lệ cao nhất 65,6%, trung bình 35,2 ± 2,5 tuần. Kết quả sau sinh: Cả 2 thai sinh ra sống tỉ lệ cao nhất 88,5%; Apgar < 7 điểm sau 1 phút: 26,3% - sau 5 phút: 19,3%; cân nặng trung bình 2211,5 ± 519,5g.

Kết luận: Song thai là một thai nghén nguy cơ cao, đặc biệt song thai một bánh nhau có các biến chứng nguy hiểm tính mạng thai nhi. Vì vậy thai phụ cần khám thai và theo dõi chặt chẽ tại Bệnh viện chuyên khoa sâu sản - nhi đế phát hiện và xử trí kịp thời các biến chứng xảy ra.
Hội chứng chuyển hóa ở nam giới các cặp vợ chồng vô sinh
Authors: Le Minh Tam , Nguyen Thi Kieu , Tran Thi Nhu Quynh , Cao Ngoc Thanh
Published: July 2020

Đặt vấn đề: Vô sinh do nam giới chiếm khoảng 50% các cặp vợ chồng vô sinh và có thể do nhiều nguyên nhân khác nhau. Hội chứng chuyển hoá (HCCH) là một vấn đề toàn cầu phổ biến, bao gồm một tập hợp các yếu tố nguy cơ tim mạch như béo phì bụng, đề kháng insulin, rối loạn lipid máu, dung nạp glucose bất thường và tăng huyết áp. Các rối loạn này có thể liên quan đến khả năng sinh sản của nam giới gồm cả chức năng tình dục và chất lượng tinh trùng. Đề tài nghiên cứu nhằm khảo sát tình trạng rối loạn chuyển hoá ở nam giới các cặp vợ chồng vô sinh và tìm hiểu các yếu tố liên quan.

Phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 231 đối tượng nam giới của cặp vợ chồng vô sinh đang điều trị tại Trung tâm Nội tiết Sinh sản và Vô sinh, Bệnh viện Đại học Y Dược Huế (HUECREI) từ 18/5/2017 đến 12/1/2019. Đối tượng được khai thác đầy đủ thông tin về lối sống, đo huyết áp và các chỉ số nhân trắc học, xét nghiệm sinh hóa máu liên quan HCCH. Chẩn đoán HCCH theo tuyên bố đồng thuận của International Diabetes Federation (IDF), National Heart, Lung and Blood Insitute (NHLBI), American Heart Association (AHA), World Heart Federation (WHF), International Atherosclerosis Society (IAS), International Association for the Study of Obesity (IASO) năm 2009.

Kết quả: Tỷ lệ mắc HCCH ở nam giới trong nhóm nghiên cứu là 25.1%, nhóm 3 thành tố chiếm tỷ lệ cao nhất với 19,0%, nhóm 4 thành tố chiếm 3,9%, nhóm 5 thành tố chiếm 2,2%. Tỷ lệ đối tượng có tăng triglycerid cao nhất với 60,6%, theo sau đó là tăng glucose máu đói (35,1%), giảm HDL-C (28,1%), tăng vòng eo (24,2%), tăng huyết áp là 9,5%. Tuổi lớn (≥35 tuổi), BMI≥23 kg/m2, tỷ số vòng bụng/vòng mông > 0,9 là những yếu tố nguy cơ độc lập cho HCCH.

Kết luận: HCCH ở nam giới các cặp vợ chồng vô sinh chiếm tỷ lệ đáng kể. Chỉ số vòng bụng, vòng bụng/chiều cao, HDL-C có giá trị dự báo khá tốt khả năng mắc HCCH. Cần có chiến lược tiếp cận sớm để hạn chế ảnh hưởng của HCCH lên khả năng sinh sản của nam giới.
ANALISIS PENGARUH PROFITABILITAS, LEVERAGE, DAN UKURAN PERUSAHAAN TERHADAP KETEPATAN WAKTU PELAPORAN KEUANGAN
Authors: Kasin, Rizka Indri Arfianti Shinta
Published: July 2020

Timeliness of financial reporting aims to provide information on the financial position, performance, and changes in the company's financial position on time before losing its ability in economic decision-making. The information in the financial statements is said to be useful when available on time when needed. The purpose of this study is to determine the effect of profitability, leverage, and company size on timeliness. The research method used is logistic regression analysis method. The sampling technique used is purposive sampling method. The samples used are 87 manufacturing companies listed on the BEI in 2014-2016 with a total of 261 data. The analysis used in this study using SPSS version 20. The results showed that profitability had a significant positive effect on timeliness at α = 5% with p-value of 0.0275, leverage did not significantly influence p-value value 0.4995, and firm size also no significant effect on timeliness with p-value of 0.350. The conclusion of this study is that there is sufficient evidence that companies with high profitability tend to be timely in delivering financial statements and there is not enough evidence of companies that have low leverage and small company size tend to be timely in delivering financial statements. Keywords: Timeliness, Profitability, Leverage, Firm Size
KOMPARASI KUALITAS INFORMASI DAN ASIMETRI INFORMASI SEBELUM DAN SESUDAH ADOPSI IFRS DI INDONESIA
Authors: Suhartono, Yustina Triyani Sugi
Published: July 2020

This research aims to provide empirical evidence relating to information quality and information asymmetry before and after IFRS adoption. This study uses value relevance as a proxy of financial report information quality and bid ask spread as a proxy of information asymmetry. The sample in this study uses secondary data 372 companies listed in Indonesia Stock Exchange form 2008 to 2016. This study uses Multiple Linear Regression method, Chow Test and Paired-Sample t Test Difference Test. The results showed that after IFRS adoption there was an increase in the quality of financial report information and a decrease in information asymmetry.Keywords: IFRS, Quality of information, Information asymmetry
Pengaruh Tingkat Pemahaman Pajak, Kualitas Pelayanan Publik, Dan Sanksi Perpajakan Terhadap Kepatuhan Wajib Pajak Kendaraan Bermotor Roda Dua Di DKI Jakarta (Studi Kasus Pengendara Ojek Online)
Authors: Chandra, Rizka Indri Arfianti Cindy Apriani
Published: July 2020

Motor Vehicle Tax is a motor vehicle that can be used for two-wheeled motor vehicles or more. Based on data obtained from the DKI Jakarta Regional Tax and Retribution Agency, the plan for the acceptance of Vehicle Tax is expected to be higher every year, but at the time of the realization of the DKI Jakarta Provincial Motor Vehicle Tax receipts the discrepancy between the plan and the realization. The purpose of this research are To know if understanding of taxation, the quality of public tax, and tax penalties effects tax compliance of two-wheeled motor vehicle taxpayers. This research uses multiple regression analysis method. Data and information obtained from the questionnaires filled out by 100 respondents who works as ojek online driver in DKI Jakarta.  The test method is performed using Likert Scale; Software SPSS 20; Validity and Reliability Test; F Test; t Test; R2 Test and the classical Assumption Test. The results of this study indicate that (1) There is no enough evidence that the understanding of taxation effects tax compliance of two-wheeled motor vehicle taxpayers. (2) There is evidence that the quality of public tax services affects tax compliance of two-wheeled motor vehicle taxpayers. (3) There is no evidence tax penalties effects tax compliance of two-wheeled motor vehicle taxpayers.Keywords: Understanding of Taxation, The Quality of Public Tax Services, Tax Penalties, Tax Compliance
RELEVANSI NILAI INFORMASI AKUNTANSI TERHADAP HARGA SAHAM YANG DIMODERASI KONSERVATISME AKUNTANSI
Authors: Chaslim, Carmel Meiden Margareta
Published: July 2020

An information content of the published financial statements is said to have value relevance if it is able to revise investor beliefs as reflected in market reaction through stock price changes. Nevertheless, many issues suggest that the value relevance of accounting information has declined, mainly due to the increasing practices of conservatism. This research purpose is to know and  prove the value relevance of accounting information and the impact of conservatism on the value relevance of the manufacturing firms listing in the Indonesian Stock Exchange in the period of 2013-2016. The sample used amounted to 320 observations consisting of 80 companies each year. Based on data analysis techniques with multiple linear regression analysis, it was found that accounting information proved to have value relevance to the stock price, as well as accounting conservatism have a different effect on each accounting information.Keywords: Value relevance, accounting information, stock price, conservatism
Pathogenic Bacterial Flora of Raw Chicken Eggs Sold in Jos, Plateau State, Nigeria
Authors: Sar TT , Johnson EA , Gberikon MG
Published: July 2020

Eggs are an important component of the diets of increasing numbers of Nigerians and are used in a number of foods such as salad dressings and home-made creams. Jos, Plateau State, Nigeria is an important source of eggs consumed in Nigeria. However, most eggs in Jos are produced by subsistence poultry farmers with poor regard for hygienic practices. To determine the bacterial load and hence sanitary health quality of eggs sold and consumed, 100 eggs were randomly sampled from egg vendors in twenty locations of Jos North, Jos South and Jos East municipalities. Dilutions of egg shell washes and egg contents were cultured on Nutrient, and subcultured on McConkey agar and Xylose Lysine Desoxycholate (XLD) agar. All egg surfaces (shells) sampled had CFUs ranging between 1.0 x 106 - 1.1 x 108/mL in Jos East, 4.3 x 105 – 6.0 x 107/mL in Jos South and 3.4 x 105 – 1.1 x 108/mL in Jos North respectively. While ANOVA and t-test showed no statistically significant differences (p>0.05) in bacterial counts from within sample locations, Chi Square (χ2) showed association (p<0.05) between bacterial counts and sample locations; Mean counts 1.06 x 109, 1.32 x 108 and 5.11 x 107 per mL respectively in Jos North, Jos East and Jos South. Eggs with bacteria isolated from their contents constituted 8(8.0%), while bacteria isolated included E. coli 65 (65%), Shigella 25 (25%) and Salmonella spp. 4(4%). E. coli was the only bacterium isolated from within 8 (8%) the eggs. While no other bacteria were found in eggs contents, the pathogenic bacteria present on the eggs indicated that eggs could be potential sources of outbreaks of food-borne diseases. Regulations and awareness on sanitary quality of eggs are advocated to help safeguard the health of the egg consuming public from egg-borne food infections.
Assessment of Haemoparasites of Cattle slaughtered in Jos South Abattoir, Plateau State, Nigeria
Authors: Okeke IO , Olufu J , Onah IE , Bako D , Wang PM , Owobu JO , Muhammad AM , Kumkat HI , Daboer PD , John SM , Waziri GB , Gargadi SD , Ango Z
Published: July 2020

Haemoparasites are considered as the most important constraints to the health and improved productivity of cattle in sub-Saharan Africa. This study was aimed at determining their prevalence among cattle slaughtered at Jos South abattoir, Plateau state, Nigeria. A total of 200 blood samples were collected between April and May, 2018. Thin and thick blood films were made from the samples and stained with Giemsa and examined microscopically using X100 magnification. A total of 128(64%) cattle were positive for Babesia species. No other haemoparasite were detected. Blood sample of 190(95%) were collected from cattle that were 3 years and above and 10(5%) were from cattle below 3 years. Female and white Fulani cattle were 2 times (POR = 2.29; P < 0.01) and 3 times (POR = 3.19; p < 0.0001) respectively at the risk of a positive result of Babesia species infection, when compared to male cattle and Red Bororo by bivariate analysis. There was no significant difference in the prevalence of Babesia species with respect to age (p = 0.27) and source of cattle (p = 1.00, p =0.96 and p = 0.56) for animals from Plateau, Bauchi and Maiduguri respectively. This study showed a high prevalence of Babsia species infection amongst slaughtered cattle at Jos South abattoir. It confirms the presence of carrier populations of Babesia-infected cattle which both serve as a reservoir of infection for tickvectors, susceptible livestock and humans. Routine screening and treatment of animals to effectively reduce to the barest minimum the prevalence of Babesia species in the study areas is highly recommended.
Effectiveness and Application of Assisted Technology in Italian Special Psycho-Education: A Pilot Study
Authors: TOTO Giusi Antonia , LIMONE Pierpaolo
Published: July 2020

Assistive technology allows to remove a number of obstacles to the complex psycho-educational needs of students with disabilities. The purpose of this research is to collect information on the knowledge, skills and perceptions of assistive technology among teachers in the context of Foggia, as a pilot study for a wider national reflection. The data were collected through consultation of official databases and through a survey, submitting to a sample of teachers a questionnaire used in an international context, translated in Italian. The results suggested that teachers do not have an adequate level of knowledge and skills in the use of assistive technology and require pre-service and in-service training to increase their general knowledge on assistive technology implementation and to plan effective actions for students with disabilities.