bluuebunny/crossref_metadata_2025 huggingface dataset:
Cultural Algorithms as a Framework for the Design of Trustable Evolutionary Algorithms
Authors: Al-Tirawi Anas , Reynolds Robert G.
Published: April 2022

One of the major challenges facing Artificial Intelligence in the future is the design of trustworthy algorithms. The development of trustworthy algorithms will be a key challenge in Artificial Intelligence for years to come. Cultural Algorithms (CAs) are viewed as one framework that can be employed to produce a trustable evolutionary algorithm. They contain features to support both sustainable and explainable computation that satisfy requirements for trustworthy algorithms proposed by Cox [Nine experts on the single biggest obstacle facing AI and algorithms in the next five years, Emerging Tech Brew, January 22, 2021]. Here, two different configurations of CAs are described and compared in terms of their ability to support sustainable solutions over the complete range of dynamic environments, from static to linear to nonlinear and finally chaotic. The Wisdom of the Crowds method was selected for the one configuration since it has been observed to work in both simple and complex environments and requires little long-term memory. The Common Value Auction (CVA) configuration was selected to represent those mechanisms that were more data centric and required more long-term memory content.

Both approaches were found to provide sustainable performance across all the dynamic environments tested from static to chaotic. Based upon the information collected in the Belief Space, they produced this behavior in different ways. First, the topologies that they employed differed in terms of the “in degree” for different complexities. The CVA approach tended to favor reduced “indegree/outdegree”, while the WM exhibited a higher indegree/outdegree in the best topology for a given environment. These differences reflected the fact the CVA had more information available for the agents about the network in the Belief Space, whereas the agents in the WM had access to less available knowledge. It therefore needed to spread the knowledge that it currently had more widely throughout the population.
Characteristics and Scoring Model of COVID-19 Severity Predictor in Obstetric and Gynecology Doctors in Indonesia
Authors: Sutrisno Sutrisno , Hapsari Wening
Published: April 2022

Background: Obstetrician and gynecologist are one of the contributors in patient care who are susceptible to contracting coronavirus-19 infection. Emergency measures for maternal field are high, while gold standard examination for COVID-19 takes long time with false negative rate. The case fatality rate of COVID-19 among health workers in Indonesia is reported to be high. We want to know epidemiological, clinical, and occupational characteristics of various degrees of COVID-19 severity and create scoring model to predict COVID-19 severity in ob/gyn doctors in Indonesia.

Method: This is a descriptive analytic study using a cross-sectional approach. Consecutive sampling was taken from ob/gyn doctors infected with COVID-19 and analyses used were Chi-Square and Mann-Whitney U tests. A scoring model is created and using receiver operating characteristic (ROC) curves, to determine the predictive ability of the scoring model and the cutoff value to COVID-19 severity, then tested for sensitivity and specificity.

Result: The mean age of the respondents was 38.2 ± 9.8 and 48.7% were male. Sixty-one percent respondents experienced mild symptoms, infected while on duty (46.1%), and 59% had nuclear family member infected with COVID-19. Age group ([Formula: see text] = 0.000), number of infection ([Formula: see text] = 0.000), vaccination status ([Formula: see text] = 0.010), comorbidities ([Formula: see text] = 0.023), and working hours ([Formula: see text] = 0.002) were significantly different on the COVID-19 severity. Area-under-curve of scoring model was 75.2% and 93.4%. The cutoff value was 10.5 points for between asymptomatic and mild degree (sensitivity 54.2% and specificity 77.8%) and 12.5 points between mild and moderate degree (sensitivity 83.3% and specificity 95.8%) respectively.

Conclusion: The developed scoring model can facilitate prediction of COVID-19 severity in ob/gyn doctors, with asymptomatic (score of < 10.5 points), mild degree (score of 10.5–12.5 points), and moderate degree (score of > 12.5 points).
A Case of 47, XXX Presenting as Secondary Amenorrhea
Authors: Kaur Harpreet , Rao Kamini A.
Published: April 2022

Objective: 47,XXX is a form of sex chromosome anomaly with an extra copy of X chromosome. It can have a varying presentation ranging from a few physical characteristics to intellectual and learning disabilities to primary ovarian insufficiency (POI). Although for most triple X syndrome patients, sexual development and fertility are normal, a few may present with amenorrhea and POI. We are presenting a case of triple X patient who presented with POI at 23 years of age. The relatively rare occurrence of this entity prompted us to report this case.

Case Presentation: Index case was presented to us at 23 years of age with secondary amenorrhea and desire for conception. Secondary sex characteristics were normal except for axillary hair that was scanty. Workup revealed a 47, XXX karyotype and a diagnosis of POI was made. We are presenting this case to highlight this important entity as a differential in cases of amenorrhea and to discuss the fertility options available in such cases.

Conclusion: Women with triple X syndrome have varying phenotypic presentations. Those presenting with POI will need hormone replacement therapy, psychological support and counselling for fertility options.
Regression Coefficient Derivation via Fractional Calculus Framework
Authors: Awadalla Muath , Noupoue Yves Yannick Yameni , Tandogdu Yucel , Abuasbeh Kinda
Published: April 2022

This study focuses on deriving coefficients of a simple linear regression model and a quadratic regression model using fractional calculus. The work has proven that there is a smooth connection between fractional operators and classical operators. Moreover, it has also been shown that the least squares method is classically used to obtain coefficients of linear and quadratic models that are viewed as special cases of the more general fractional derivative approach which is proposed.
Floor Disturbance and Failure Characteristics of Super-Large Mining Height Working Face
Authors: Lu Cunjin , Xu Jinpeng , Zhao Hui , Zhang Heng , Zhang Yian , Chen Mingyue
Published: April 2022

The failure depth of the working face floor caused by mining is a key parameter to predict water inrush from the working face floor. Extensive research has been conducted on the floor failure zone of the working face. However, in recent years, there have been few studies on the floor failure law of the working face with a super-large mining height (over 20 m) in the western mining area of China. In this paper, the working face with a super-large mining height of 24 m in Longwanggou Coal Mine was studied. Electrical monitoring and numerical simulation of the working face floor were carried out. The measured floor failure depth of the working face is 15 m while the average numerical simulation result is 11 m. When compared with the calculation results of the statistical analysis formulas, the floor failure depth of the working face with a super large mining height obtained from field measurement and numerical simulation is smaller. The reason for the smaller failure zone of the floor of the super large mining height working face is that the falling roof inhibits the pressure relief of the floor, the large mining height reduces the advance pressure, and the shear stress of the floor decreases. The research methods and findings are of great significance to the prediction of floor failure and water inrush in working face with a super-large mining height, the prevention and control of water disasters in coal seam roof and the monitoring of mine pressure.
Overexpression of Aquaporin-3 Alleviates Hyperosmolarity-Induced Nucleus Pulposus Cell Apoptosis via Regulating the ERK1/2 Pathway
Authors: Zhang Zetong , Zhao Chen , Zhang Ruijie , Wang Yiyang , Hu Yanzhu , Zhou Qiang , Li Pei
Published: April 2022

Intervertebral disc degeneration (IDD) is closely related to osmolarity, which fluctuates with daily activities, and hyperosmolarity may be a contributor to nucleus pulposus (NP) cells apoptosis. Aquaporin-3 (AQP-3) belongs to the family of aquaporins and mainly transports water and other small molecular proteins, which is reduced with the aging of the intervertebral disc. ERK1/2 pathway is one type of mitogen-activated protein kinase (MAPK) and is associated with cellular apoptosis. This study was aimed to investigate the effects of AQP-3 on NP cells apoptosis induced by a hyperosmolarity and focused on the role of the ERK1/2 signaling pathway. We found that NP apoptosis could be induced by hyperosmolarity (550 mOsm/kg), and downregulation of AQP-3 and inhibition of ERK1/2 could be simultaneously observed. Therefore, lentivirus was used to enhance the expression of AQP-3 to compare apoptosis between AQP-3-overexpressed NP cells and the control NP cells. The results showed that apoptosis could be alleviated by overexpression of AQP-3 and the activity of ERK1/2 could also be promoted. Furthermore, we found that the inhibitor U0126 could partly aggravate apoptosis of the AQP-3-overexpressed NP cells. In summary, our results suggested that overexpression of AQP-3 could protect against hyperosmolarity-induced NP cell apoptosis via promoting the activity of the ERK1/2 pathway. This study may shed light on a better understanding of the pathologic mechanism of IDD and bring AQP-3 into the therapeutic approaches for IDD treatment.
Design and Analysis of Clothing Catwalks Taking into Account Unity's Immersive Virtual Reality in an Artificial Intelligence Environment
Authors: Hong Yu , Ge Yuemeng
Published: April 2022

In the context of the rapid development of AI area, VR technology is raising the public and researchers’ attention. This study constructs a VR clothing catwalk based on the Unity 3D game engine in the AI background. This article focuses on the study of Unity 3D to construct the scenes and costumes of the clothing catwalk and then combine the immersive experience of VR to achieve the feeling of VR. Therefore, this article designs the scenes and model costumes of the VR clothing show by analyzing the VR technology in the context of the AI environment, combined with the Unity 3D game engine. It optimizes the VR clothing show based on Unity 3D game engine designed in this paper through design performance test experiment and visual positioning comparison experiment and then investigates and analyzes the optimized VR clothing show. Based on user feedback, this article completes the function of VR clothing show and compares it with the traditional online clothing show. The experimental results show that the sensory evaluation given by users is 22.02% higher than that of users of traditional online clothing shows. In the clothing catwalk based on Unity immersive VR, the user's rating for the fluency of watching is 10.99% higher than that of the traditional online clothing catwalk.
Study of Nursing Models by Machine Learning in Children with Congenital Esophageal Atresia
Authors: Zhang Yu , Sun Xueqiang , Shi Jingyun , Xiao Zhenjuan
Published: April 2022

This research paper elucidates the clinical effect of an integrated nursing model of medical care and patient in the diagnosis and treatment of congenital esophageal atresia (CEA). For this purpose, a total of 120 children with CEA were selected as study subjects who were admitted to our hospital (January 2017 to April 2020). They were randomly divided into the control group and observation group. Each group had 60 cases. The control group was given routine nursing, while the observation group adopted the integrated nursing model of medical care. The integrated nursing model had the characteristics of recognizing and managing the CEA quickly and efficiently. Thus, it can help increase the survival rate of infants. This model works along with the parents to provide specialized services to the child. They were tasked to carefully observe the infants as well as calm the parents. They were also given the additional task of keeping track of patients who were currently admitted in the hospital and those who were already discharged. The tracking and communication were done with the help of a communication platform which is WeChat. The rehospitalization rate, 1-hour visit rate, accuracy rate of children with suspected postoperative complications, psychological status of children’s parents, medical compliance, and satisfaction were compared between the two groups. The rehospitalization rate in the observation group was lower than that in the control group (

P
<
0.05

). The 1-hour visit rate and accuracy of children with suspected postoperative complications in the observation group were higher than those in the control group (

P
<
0.05

). The anxiety and depression scores of the parents in the observation group were lower than those in the control group (

P
<
0.05

). The compliance and satisfaction of parents in the observation group were higher than those in the control group (

P
<
0.05

). The clinical effect of the integrated nursing model of medical care and patient in CEA was highly satisfactory. It reduces the rehospitalization rate and enables timely diagnosis and treatment of suspicious complications effectively. It also improved parents’ negative psychological emotions, compliance, and satisfaction.
Development and Validation of Ultrahigh-Performance Liquid Chromatography Coupled with Triple Quadrupole Mass Spectrometry Method for Quantitative Determination of Ten Active Compounds in Ge-Gen-Jiao-Tai-Wan
Authors: Wang Wenbo , Zhu Shuangquan , Chen Hao , Wu Ning , Chen Han , Wang Dongsheng
Published: April 2022

A rapid, accurate, and sensitive method for the simultaneous determination of 10 main components, namely puerarin, daidzin, coptisine, epiberberine, jatrorrhizine, berberine, palmatine, coumarin, daidzein, and cinnamic acid in Ge-Gen-Jiao-Tai-Wan, was developed based on ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry. Analysis was performed on an Agilent 1290 Infinity II series UHPLC system, equipped with a Waters ACQUITY UPLC HSS T3 column (100 × 2.1 mm, 1.8 μm) by using (A) 0.1% acetic acid and (B) methanol as mobile phase. The flow rate was 0.3 mL/min, and the injection volume was 1 μL. Mass spectrometry was operated in multiple reaction monitoring mode using an Agilent 6460 triple quadrupole mass spectrometer equipped with an AJS-ESI ion source. Agilent Mass Hunter Work Station Software was employed for data acquisition and processing. All calibration curves showed excellent linear regressions (R2 > 0.9992). The precision, repeatability, and stability of the ten compounds were below 4.56% in terms of relative standard deviation. The average extraction recovery ranged from 96.53% to 102.69% with a relative standard deviation of 1.14–3.78% for all samples. This study potently contributes to the quantitative evaluation of Ge-Gen-Jiao-Tai-Wan, thereby providing a scientific basis for further studies and clinical application of Ge-Gen-Jiao-Tai-Wan.
New Exact Solutions of Burgers’ Equation Using Power Index Method
Authors: Ahmad Khalil , Bibi Khudija
Published: April 2022

In this article, we focus on the new exact solutions of Burger’s equation by using a new technique which is known as the power index method (PIM). In this method, we choose suitable indexes of independent variables and similarity transformation so that the partial differential equation may be converted into ODE. We have obtained analytic solution of the ODE by using symbolic package Maple. We have got exact solution of Burgers’ equation by using analytic solution of ODE and similarity transformation. The proposed method has been effectively employed to find new exact solutions for the nonlinear Burgers’ equation. Finally, the proposed resulting answers are compared with the homotopy perturbation, decomposition, and variational iteration solutions.
Estimated Failure to Report Unsuccessful Quit Attempts by Type of Cessation Aid: A Population Survey of Smokers in England
Authors: Perski Olga , West Robert , Brown Jamie , Mohamed Haniki
Published: April 2022

Introduction. It has been estimated that smokers tend to fail to report unsuccessful quit attempts that lasted a short time and occurred a longer time ago. However, it is unclear whether the failure to report unsuccessful quit attempts varies by the type of cessation aid used. Methods. A total of 5,892 smokers aged 16+ years who had made 1+ quit attempts in the past year were surveyed between January 2014 and December 2020 as part of the Smoking Toolkit Study. Respondents indicated when their most recent quit attempt started, how long it lasted, and which cessation aid(s) were used (e.g., unaided, varenicline, and behavioural support). The percentage failure to report for each cessation aid and 95% bootstrap confidence intervals (CIs) were estimated with an established method. Test for equality of proportions was performed to examine whether quit attempts lasting between one day and one week and that started >6 months ago failed to be reported at a different rate depending on the cessation aid used. Results. We estimated that after three months, 97% (95% CI = 96%-98%) of unaided quit attempts lasting less than one day, 80% (95% CI = 79%-81%) of those lasting between one day and one week, and 60% (95% CI = 59%-61%) of those lasting between one week and one month fail to be reported. Compared with unaided attempts, the estimated percentage failure to report quit attempts that lasted between one day and one week and that started >6 months ago was significantly lower for attempts involving behavioural support (92% of unaided attempts vs. 75% of attempts involving behavioural support, <mml:math xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mnf="http://cambridge.org/core/manifest" xmlns:cup="http://contentservices.cambridge.org" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:m="http://cambridge.org/core/metadata" xmlns:core="http://cambridge.org/core" xmlns:c="http://cambridge.org/core/content" id="M4">χ21=9.29, p = 0.002). No other significant differences were detected. Conclusions. Smokers in England appear to fail to report a substantial proportion of unsuccessful quit attempts. This failure appears particularly prominent for attempts that last a short time or occurred longer ago and appears lower for attempts involving behavioural support compared with unaided attempts.
An Operational Matrix Technique Based on Chebyshev Polynomials for Solving Mixed Volterra-Fredholm Delay Integro-Differential Equations of Variable-Order
Authors: Raslan Kamal R. , Ali Khalid K. , Mohamed Emad M. H. , Younis Jihad A. , Abd El salam Mohamed A.
Published: April 2022

In this work, an algorithm for finding numerical solutions of linear fractional delay-integro-differential equations (LFDIDEs) of variable-order (VO) is introduced. The operational matrices are used as discretization technique based on shifted Chebyshev polynomials (SCPs) of the first kind with the spectral collocation method. The proposed VO-LFDIDEs have multiterms of integer, fractional-order derivatives for delayed or nondelayed and mixed Volterra-Fredholm integral terms. The introduced model is a more general form of linear fractional VO pantograph, neutral, and mixed Fredholm–Volterra integro-differential equations with delay arguments. Caputo’s VO fractional derivative operator is used to generate the matrices of the derivative. Operational matrices are presented for all terms. The reliability and efficiency of the proposed scheme are demonstrated by some numerical experiments. Also, some examples are included to improve the validity and applicability of the techniques. Finally, comparisons between the proposed method and other methods were used to solve this kind of equation.
Traumatic Metachronous Penile Fracture to the Contralateral Corpora
Authors: Papaioannou Christos , Omorphos Savvas
Published: April 2022

Penile fracture is an uncommon condition in day-to-day urological practice. Though most cases of penile fracture are traumatic in nature, these are typically unilateral. Synchronous bilateral cases have been rarely reported. We present the third case recorded to date, to the best of our knowledge, of a metachronous penile fracture to the contralateral corpora due to trauma related to sexual intercourse. The first presentation demonstrated a significant tear to the left corporal body at surgical exploration that was repaired. There was no postoperative complications or erectile dysfunction on outpatient follow-up. Six months thereafter, the patient had another similar presentation and demonstrated a right corporal body fracture which was repaired surgically on an urgent basis. Prompt diagnosis and low threshold for surgical intervention are essential to reduce morbidity and prevent long-term complications.
Teledentistry in the Management of Patients with Dental and Temporomandibular Disorders
Authors: Minervini Giuseppe , Russo Diana , Herford Alan Scott , Gorassini Francesca , Meto Aida , D’Amico Cesare , Cervino Gabriele , Cicciù Marco , Fiorillo Luca
Published: April 2022

Telemedicine is a subunit of telehealth, and it uses telecommunication technology, video, digital images, and electronic medical records to allow the exchange of clinical information and images over remote distances for dental consultation, diagnosis, and treatment planning. Dental clinical practice requires face‐to‐face interaction with the patients, and therefore, during the COVID‐19 pandemic, it has mostly been suspended. In this view, teledentistry offers the opportunity to continue dental practice, avoiding the face‐to‐face examination that put patients and healthcare professionals at infection risk. Teledentistry encompasses several subunits such as teleconsultation, telediagnosis, telemonitoring, and teletriage. To date, there are several experiences described in literature that suggest that teledentistry could be applied to support traditional care of different oral diseases. However, there are some issues that need to be addressed. Reimbursement concerns, costs, license regulations, limits in physical examinations, and expert equipment are principal issues that should be overcome in telemedicine and in teledentistry. In this narrative review, we provide an overview of the different teledentistry approaches in the care of patients with dental and temporomandibular disorders, as well as discussing the issues that need to be addressed to implement this approach in clinical practice.
Pulmonary Manifestations of Primary Humoral Deficiencies
Authors: Casal Ana , Riveiro Vanessa , Suárez-Antelo Juan , Ferreiro Lucía , Rodríguez-Núñez Nuria , Lama Adriana , Toubes María Elena , Valdés Luis
Published: April 2022

Primary immunodeficiencies are a group of conditions characterized by developmental or functional alterations in the immune system caused by hereditary genetic defects. Primary immunodeficiencies may affect either the innate or the adaptive (humoral and cellular) immune system. Pulmonary complications in primary humoral deficiencies are frequent and varied and are associated with high morbidity and mortality rates. The types of complications include bronchiectasis secondary to recurrent respiratory infections and interstitial pulmonary involvement, which can be associated with autoimmune cytopenias, lymphoproliferation, and a range of immunological manifestations. Early detection is key to timely management. Immunoglobulin replacement therapy reduces the severity of disease, the frequency of exacerbations, and hospital admissions in some primary humoral deficiencies. Therefore, the presence of pulmonary disease with concomitant infectious and/or autoimmune complications should raise suspicion of primary humoral deficiencies and warrants a request for immunoglobulin determination in blood. Once diagnosis is confirmed; early immunoglobulin replacement therapy will improve the course of the disease. Further studies are needed to better understand the pathogenesis of pulmonary disease related to primary humoral deficiencies and favor the development of targeted therapies that improve the prognosis of patients.
PTPN11 Gene Mutations and Its Association with the Risk of Congenital Heart Disease
Authors: Xu Zi-qing , Chen Wei-cheng , Li Yu-jie , Suo Mei-jiao , Tian Gui-xiang , Sheng Wei , Huang Guo-ying
Published: April 2022

Congenital heart disease (CHD) is the most common congenital birth defect, with a prevalence of 8.98‰ of all live births in China. PTPN11 has been known to be closely involved in heart developments. In this research, we carried out whole-exome sequencing in nine CHD families and identified eight rare deleterious missense variants of PTPN11 gene in nine probands by stringently filtering criteria. Sanger sequencing of these probands and their unaffected familiar members revealed that six damaging variants were de novo in seven CHD families. Then, targeted sequencing was used to assess the PTPN11 exon variants in 672 sporadic CHD cases and 399 unrelated controls and identified 7 deleterious missense variants in 8 patients. Fisher’s exact test reveals a significant association of PTPN11 variations with CHD (

P
=
0.0289

). We observed the distribution of different subtypes in CHD patients with PTPN11 variants and found atrial septal defect (ASD) is a prominent phenotype (58.8%, 10/17). In vitro functional assays revealed that the predicted PTPN11 variants disturb RAS-mitogen-activated protein kinase signaling activity by influencing the phosphorylation level of pathway proteins and increasing the proliferation and migration abilities of cardiomyocytes to different extents. Our findings demonstrated that PTPN11 variants were associated with increased risk of CHD development and may be served as an important susceptible genetic event for CHD, especially the ASD subphenotype.
Dynamic Performance Analysis of STEP System in Internet of Vehicles Based on Queuing Theory
Authors: Li Huiyong , Wu Xiaofeng , Wang Yanhong
Published: April 2022

The Internet of vehicles (IoV) is an important research area of the intelligent transportation systems using Internet of things theory. The complex event processing technology is a basic issue for processing the data stream in IoV. In recent years, many researchers process the temporal and spatial data flow by complex event processing technology. Spatial Temporal Event Processing (STEP) is a complex event query language focusing on the temporal and spatial data flow in Internet of vehicles. There are four processing models of the event stream processing system based on the complex event query language: finite automata model, matching tree model, directed acyclic graph model, and Petri net model. In addition, the worst-case response time of the event stream processing system is an important indicator of evaluating the performance of the system. Firstly, this paper proposed a core algorithm of the temporal and spatial event stream processing program based on STEP by Petri net model. Secondly, we proposed a novel method to estimate the worst-case response time of the event stream processing system, which is based on stochastic Petri net and queuing theory. Finally, through the simulation experiment based on queuing theory, this paper proves that the data stream processing system based on STEP has good dynamic performance in processing the spatiotemporal data stream in Internet of vehicles.
SCU-Net: Semantic Segmentation Network for Learning Channel Information on Remote Sensing Images
Authors: Wang Wei , Kang Yuxi , Liu Guanqun , Wang Xin
Published: April 2022

Extracting detailed information from remote sensing images is an important direction in semantic segmentation. Not only the amounts of parameters and calculations of the network model in the learning process but also the prediction effect after learning must be considered. This paper designs a new module, the upsampling convolution-deconvolution module (CDeConv). On the basis of CDeConv, a convolutional neural network (CNN) with a channel attention mechanism for semantic segmentation is proposed as a channel upsampling network (SCU-Net). SCU-Net has been verified by experiments. The mean intersection-over-union (MIOU) of the SCU-Net-102-A model reaches 55.84%, the pixel accuracy is 91.53%, and the frequency weighted intersection-over-union (FWIU) is 85.83%. Compared with some of the state-of-the-art methods, SCU-Net can learn more detailed information in the channel and has better generalization capabilities.
The Use of Internet of Things and Cloud Computing Technology in the Performance Appraisal Management of Innovation Capability of University Scientific Research Team
Authors: Meng Siyu , Zhang Xue
Published: April 2022

This study aims to speed up the progress of scientific research projects in colleges and universities, continuously improve the innovation ability of scientific research teams in colleges and universities, and optimize the current management methods of performance appraisal of college innovation ability. Firstly, the needs of the innovation performance evaluation system are analyzed, and the corresponding innovation performance evaluation index system of scientific research team is constructed. Secondly, the Internet of Things (IoT) combines the Field Programmable Gate Array (FPGA) to build an innovation capability performance appraisal management terminal. Thirdly, the lightweight deep network has been built into the innovation ability performance assessment management network of university scientific research teams, which relates to the innovation performance assessment index system of scientific research teams. Finally, the system performance is tested. The results show that the proposed method has different degrees of compression for MobileNet, which can significantly reduce the network computation and retain the original recognition ability. Models whose Floating-Point Operations (FLOPs) are reduced by 70% to 90% have 3.6 to 14.3 times fewer parameters. Under different pruning rates, the proposed model has higher model compression rate and recognition accuracy than other models. The results also show that the output of the results is closely related to the interests of the research team. The academic influence score of Team 1 is 0.17, which is the highest among the six groups in this experimental study, indicating that Team 1 has the most significant academic influence. These results provide certain data support and method reference for evaluating the innovation ability of scientific research teams in colleges and universities and contribute to the comprehensive development of efficient scientific research teams.
Comparative Analysis of TOPSIS and TODIM for the Performance Evaluation of Foreign Players in Indian Premier League
Authors: Dutta Vaishnudebi , Haldar Subhomoy , Kaur Prabjot , Gajpal Yuvraj
Published: April 2022

Sports officials, players, and fans are concerned about overseas player rankings for the IPL auction. These rankings are becoming progressively essential to investors when premium leagues are commercialized. The decision‐makers of the Indian Premier League choose cricketers based on their own experience in sports and based on performance statistics on several criteria. This paper presents a scientific way to rank the players. Our research examines and contrasts different multicriteria decision‐making algorithms for ranking foreign players under various criteria to assess their performance and efficiency. The paper uses three MCDM algorithms, TOPSIS, TODIM, and NR‐TOPSIS, for foreign players ranking in the Indian Premier League. Our analysis is limited to the batsmen and bowlers only. We perform the analysis using Python language, a popular high‐level programming language. Finally, we perform a sensitivity analysis to determine the stability of each method when the weights of the criterion or the value of a parameter was changed. Our analysis exhibits the superiority of TODIM over TOPSIS and NR‐TOPSIS.
The Genomic Landscape of Early-Stage Ovarian High-Grade Serous Carcinoma
Authors: Cheng Zhao , Mirza Hasan , Ennis Darren P. , Smith Philip , Morrill Gavarró Lena , Sokota Chishimba , Giannone Gaia , Goranova Theodora , Bradley Thomas , Piskorz Anna , Lockley Michelle ,   For the BriTROC-1 Investigators, Kaur Baljeet , Singh Naveena , Tookman Laura A. , Krell Jonathan , McDermott Jacqueline , Macintyre Geoffrey , Markowetz Florian , Brenton James D. , McNeish Iain A.
Published: April 2022

Purpose:

Ovarian high-grade serous carcinoma (HGSC) is usually diagnosed at late stage. We investigated whether late-stage HGSC has unique genomic characteristics consistent with acquisition of evolutionary advantage compared with early-stage tumors.

Experimental Design:

We performed targeted next-generation sequencing and shallow whole-genome sequencing (sWGS) on pretreatment samples from 43 patients with FIGO stage I–IIA HGSC to investigate somatic mutations and copy-number (CN) alterations (SCNA). We compared results to pretreatment samples from 52 patients with stage IIIC/IV HGSC from the BriTROC-1 study.

Results:

Age of diagnosis did not differ between early-stage and late-stage patients (median 61.3 years vs. 62.3 years, respectively). TP53 mutations were near-universal in both cohorts (89% early-stage, 100% late-stage), and there were no significant differences in the rates of other somatic mutations, including BRCA1 and BRCA2. We also did not observe cohort-specific focal SCNA that could explain biological behavior. However, ploidy was higher in late-stage (median, 3.0) than early-stage (median, 1.9) samples. CN signature exposures were significantly different between cohorts, with greater relative signature 3 exposure in early-stage and greater signature 4 in late-stage. Unsupervised clustering based on CN signatures identified three clusters that were prognostic.

Conclusions:

Early-stage and late-stage HGSCs have highly similar patterns of mutation and focal SCNA. However, CN signature analysis showed that late-stage disease has distinct signature exposures consistent with whole-genome duplication. Further analyses will be required to ascertain whether these differences reflect genuine biological differences between early-stage and late-stage or simply time-related markers of evolutionary fitness.

See related commentary by Yang et al., p. 2730
Oncogene Convergence in Extrachromosomal DNA Hubs
Authors: Weiser Natasha E. , Hung King L. , Chang Howard Y.
Published: April 2022

Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs—local congregations of ecDNAs in the nucleus—highlight unique features of ecDNA biology that may contribute to higher oncogene expression and rapid tumor evolution.
Revision of the Metallactus taeniatellus species group (Coleoptera: Chrysomelidae: Cryptocephalinae)
Authors: SASSI DAVIDE
Published: April 2022

The taeniatellus species group of Neotropical Metallactus Suffrian, 1866 of the subtribe Pachybrachina is defined and 10 species are revised and assigned to the group. Four of them already belonged to Metallactus. They are: Metallactus taeniatellus, Suffrian, 1866, M. insitivus, Suffrian, 1866, M. latiusculus, Suffrian, 1866, M. planipennis, Suffrian, 1866. Four additional species, formerly included in Griburius Haldemann, 1849 (= Scolochrus, Suffrian, 1852), are transferred to Metallactus and assigned to the M. taeniatellus species group: Metallactus cultus (Suffrian, 1866) comb. nov., M. quadrinus (Suffrian, 1866) comb. nov., M. superbiens (Suffrian, 1866) comb. nov. and M. multicolor (Jacoby, 1899) comb. nov. Two additional species are described as new to science: Metallactus geiseri sp. nov. and M. uncinatus sp. nov. Lectotypes are designated for Metallactus cultus, M. insitivus, M. latiusculus, M. multicolor, M. planipennis, M. quadrinus, M. superbiens, and M. taeniatellus. Description, figures, and range maps are given for each species. An identification key for the species in the taeniatellus species group is also provided.
A new species of planthopper in the genus Tico (Hemiptera: Auchenorrhyncha: Derbidae) on palms from lowland tropical rainforest in Costa Rica
Authors: BAHDER BRIAN W. , ECHAVARRIA MARCO A. ZUMBADO , BARRANTES EDWIN A. BARRANTES , HELMICK ERICKA E. , BARTLETT CHARLES R.
Published: April 2022

Recently, the genus Tico Bahder & Bartlett was described as part of ongoing research focused on planthopper diversity on palms in Costa Rica to accommodate two new species and the transfer of one species from Cenchrea Westwood. Herein, a new species of Tico is described from palms and Heliconia spp. at the La Selva Biological Station in Costa Rica. Placement of the novel taxon is supported by molecular analysis of the cytochrome c oxidase subunit I (COI) gene and 18S rRNA gene.
Spotted beauty—Gedanochila museisucini gen. et sp. nov.—a new Achilidae from Eocene Baltic amber (Hemiptera: Fulgoromorpha) and its relation to Achilini
Authors: BRYSZ ALICJA MAGDALENA , BOURGOIN THIERRY , SZWEDO JACEK
Published: April 2022

Gedanochila museisucini gen. et sp. nov. is described, based on inclusions in the Eocene Baltic amber. A morphological phylogenetic analysis supports the placement of Gedanochila gen. nov. into the tribe Achilini. Definition, content and subdivisions of the tribe as well as position of extinct taxa placed within are briefly discussed.
Descriptions of the mature larva and pupa of Pseudopyrochroa facialis (Fairmaire) from Southwest China (Coleoptera: Pyrochroidae: Pyrochroinae), with redescriptions of adult stages and notes on natural history
Authors: ZHAN ZHIHONG , LIU YANCHEN , YOUNG DANIEL K.
Published: April 2022

Larvae and pupae of Pseudopyrochroa facialis were collected beneath bark and in coarse, decaying woody debris of a standing, dead Cyclobalanopsis glauca tree in Guiyang City, Guizhou Province, China. The species association was confirmed by rearing both males and females to the adult stage. This represents the first record of a mainland Chinese species of Pseudopyrochroa to be reared in order to establish species association and identity. The mature larva and pupa are described and illustrated along with descriptions and illustrations of reared and additional adult males and females. Observations relating to the larval/pupal macro- and microhabitats and natural history are provided.
Identification and characterization of circular RNAs in association with the feed efficiency in Hu lambs
Authors: Zhang Deyin , Zhang Xiaoxue , Li Fadi , Li Xiaolong , Zhao Yuan , Zhang Yukun , Zhao Liming , Xu Dan , Wang Jianghui , Yang Xiaobin , Cui Panpan , Wang Weimin
Published: April 2022

Background

Circular RNA (circRNA), as a new members of noncoding RNA family, have vital functions in many biological processes by as microRNA sponges or competing endogenous RNAs (ceRNAs). However, little has been reported about the genetic mechanism of circRNAs regulation of feed efficiency in sheep.

Results

This study aimed to explore the expression of circRNAs in the liver of Hu sheep with High-RFI (High residual feed intake) and Low-RFI (Low residual feed intake) using transcriptome sequencing. A total of 20,729 circRNAs were identified in two groups, in which 219 circRNAs were found as significantly differentially expressed. Several circRNAs were validated by using RT-PCR, sanger sequencing and RT-qPCR methods. These results demonstrated that the RNA-seq result and expression level of circRNAs identified are reliable. Subsequently, GO and KEGG enrichment analysis of the parental genes of the differentially expressed (DE) circRNAs were mainly involved in immunity response and metabolic process. Finally, the ceRNA regulatory networks analysis showed that the target binding sites for miRNA such as novel_41, novel_115, novel_171 and oar-miR-485-3p in the identified DE cirRNAs. Importantly, two metabolic (SHISA3 and PLEKHH2) and four (RTP4, CD274, OAS1, and RFC3) immune-related target mRNAs were identified from 4 miRNAs. Association analysis showed that the polymorphism (RTP4 c.399 A > G) in the target gene RTP4 were significantly associated with RFI (P < 0.05).

Conclusions

Analysis of sequencing data showed some candidate ceRNAs that may play key roles in the feed efficiency in sheep by regulating animal immune and metabolic. These results provide the basis data for further study of the biological functions of circRNAs in regulating sheep feed efficiency.
Systematic reviews and meta-analysis published in indexed Portuguese medical journals: time trends and critical appraisal
Authors: Prada Luísa , Prada Ana , Antunes Miguel Marques , Fernandes Ricardo M. , Costa João , Ferreira Joaquim J. , Caldeira Daniel
Published: April 2022

Introduction

Over the last years, the number of systematic reviews published is steadily increasing due to the global interest in this type of evidence synthesis. However, little is known about the characteristics of this research published in Portuguese medical journals. This study aims to evaluate the publication trends and overall quality of these systematic reviews.

Material and methods

This was a methodological study. We aimed the most visible Portuguese medical journals indexed in MEDLINE. Systematic reviews were identified through an electronic search (through PUBMED). We included systematic reviews published up to August 2020. Systematic reviews selection and data extraction were done independently by three authors. The overall quality critical appraisal using the A MeaSurement Tool to Assess systematic Reviews (AMSTAR-2) was independently assessed by three authors. Disagreements were solved by consensus.

Results

Sixty-six systematic reviews published in 5 Portuguese medical journals were included. Most (n = 53; 80.3%) were systematic reviews without meta-analysis. Up to 2010 there was a steady increase in the number of systematic reviews published, followed by a period of great variability of publication, ranging from 1 to 10 in a given year. According to the systematic reviews’ typology, most have been predominantly conducted to assess the effectiveness/efficacy of health interventions (n = 27; 40.9%). General and Internal Medicine (n = 20; 30.3%) was the most addressed field. Most systematic reviews (n = 46; 69.7%) were rated as being of “critically low-quality”.

Conclusions

There were consistent flaws in the methodological quality report of the systematic reviews included, particularly in establishing a prior protocol and not assessing the potential impact of the risk of bias on the results.

Through the years, the number of systematic reviews published increased, yet their quality is suboptimal. There is a need to improve the reporting of systematic reviews in Portuguese medical journals, which can be achieved by better adherence to quality checklists/tools.
Development and evaluation of a search filter to identify prognostic factor studies in Ovid MEDLINE
Authors: Stallings Elena , Gaetano-Gil Andrea , Alvarez-Diaz Noelia , Solà Ivan , López-Alcalde Jesús , Molano Daniel , Zamora Javier
Published: April 2022

Background

Systematic reviews (SRs) are valuable resources as they address specific clinical questions by summarizing all existing relevant studies. However, finding all information to include in systematic reviews can be challenging. Methodological search filters have been developed to find articles related to specific clinical questions. To our knowledge, no filter exists for finding studies on the role of prognostic factor (PF). We aimed to develop and evaluate a search filter to identify PF studies in Ovid MEDLINE that has maximum sensitivity.

Methods

We followed current recommendations for the development of a search filter by first identifying a reference set of PF studies included in relevant systematic reviews on the topic, and by selecting search terms using a word frequency analysis complemented with an expert panel discussion. We evaluated filter performance using the relative recall methodology.

Results

We constructed a reference set of 73 studies included in six systematic reviews from a larger sample. After completing a word frequency analysis using the reference set studies, we compiled a list of 80 of the frequent methodological terms. This list of terms was evaluated by the Delphi panel for inclusion in the filter, resulting in a final set of 8 appropriate terms. The consecutive connection of these terms with the Boolean operator OR produced the filter. We then evaluated the filter using the relative recall method against the reference set, comparing the references included in the SRs with our new search using the filter. The overall sensitivity of the filter was calculated to be 95%, while the overall specificity was 41%. The precision of the filter varied considerably, ranging from 0.36 to 17%. The NNR (number needed to read) value varied largely from 6 to 278. The time saved by using the filter ranged from 13–70%.

Conclusions

We developed a search filter for OVID-Medline with acceptable performance that could be used in systematic reviews of PF studies. Using this filter could save as much as 40% of the title and abstract screening task. The specificity of the filter could be improved by defining additional terms to be included, although it is important to evaluate any modification to guarantee the filter is still highly sensitive.
Comparison of reference distributions acquired by direct and indirect sampling techniques: exemplified with the Pediatric Reference Interval in China (PRINCE) study
Authors: Yan Ruohua , Li Kun , Lv Yaqi , Peng Yaguang , Van Halm-Lutterodt Nicholas , Song Wenqi , Peng Xiaoxia , Ni Xin
Published: April 2022

Background

Our study aimed to compare the reference distributions of serum creatinine and urea obtained by direct sampling technique and two indirect sampling techniques including the Gaussian Mixture Model (GMM) and the Self-Organizing Map (SOM) clustering based on clinical laboratory records, so that the feasibility as well as the potential limitations of indirect sampling techniques could be clarified.

Methods

The direct sampling technique was used in the Pediatric Reference Interval in China (PRINCE) study, in which 15,150 healthy volunteers aged 0 to 19 years were recruited from 11 provinces across China from January 2017 to December 2018. The indirect sampling techniques were used in the Laboratory Information System (LIS) database of Beijing Children’s Hospital, in which 164,710 outpatients were included for partitioning of potential healthy individuals by GMM or SOM from January to December 2016. The reference distributions of creatinine and urea that were established by the PRINCE study and the LIS database were compared.

Results

The density curves of creatinine and urea based on the PRINCE data and the GMM and SOM partitioned LIS data showed a large overlap. However, deviations were found in reference intervals among the three populations.

Conclusions

Both GMM and SOM can identify potential healthy individuals from the LIS data. The performance of GMM is consistent and stable. However, GMM relies on Gaussian fitting, and thus is not suitable for skewed data. SOM is applicable for high-dimensional data, and is adaptable to data distribution. But it is susceptible to sample size and outlier detection strategy.