bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of Apriori Algorithm Data Mining for Increase Sales
Authors: Alfianzah Reza , Handayani Rani Irma , Murniyati Murniyati
Published: October 2020

Any company or organization that wants to survive needs to determine the right business strategy. The product sales data carried out by Lakoe Dessert Pondok Kacang will eventually result in a pile of data, so it is unfortunate if it is not re-analyzed. The products offered vary with a wide variety of products as many as 45 products, to find out the products with the most sales and the relationship between one product and another, one of the algorithms is needed in the data mining algorithm, namely the a priori algorithm to find out, and with the help of the Rapidminer 5 application, with a support value 2,4% and a confidence value 50%, products that customers often buy or are interested in can be found. This study used sales data for March 2020, which amounted to 209 transaction data. From the research, it was found that the item with the name Pudding Strawberry and Pudding Vanilla was the product most purchased by consumers. With knowledge of the most sold products and the patterns of purchasing goods by consumers, Lakoe Dessert Pondok Kacang can develop marketing strategies to market other products by analyzing the profits from selling the most sold products and anticipating running out or empty of stock or materials at a later date.
Expert System for Diagnosing Pregnancy Complaints by Forward Chaining
Authors: Wati Embun Fajar , Puspitasari Anggi
Published: October 2020

Limited time in consulting becomes an obstacle for midwives in diagnosing complaints in pregnant women, especially those who are already in the III trimester and approaching the labor process. Misdiagnosis results in inaccuracies in the provision of solutions and actions. Initial treatment that corresponds to the complaints of pregnant women especially the third trimester is expected to reduce mortality rates in the mother and fetus. Expert System can be a timely solution with not too long so as to improve the quality of examination on midwives. The methods used are identification, primary and secondary data collection, forward chaining data analysis combined with bayesian, and evaluation with the calculation of the percentage of system success. Samples taken by 20 patients and 4 patients were declared unsyed because they had only one complaint. Meanwhile, 16 patients had some complaints that complied with the Rules. A total of 11 out of 16 patients or about 70% had valid results between the diagnosis of experts/midwives with the system. It can be concluded that the system works well to diagnose complaints in patients with a third trimester gestational age so that midwives can provide appropriate initial solutions and treatment in reducing maternal and infant mortality.
Design of an Automatic Water Pump on a Traditional Boat
Authors: Ihsan Ihsan , Ilham Dirja Nur , Candra Rudi Arif , Yunan Amsar , Hardisal Hardisal
Published: October 2020

Draining traditional boat water efficiently is sometimes considered to be of little importance to most fishermen. Because it is considered a normal thing without realizing it can be detrimental, both in terms of time and work. One of the things that often makes the use of draining water less efficient is that the draining of boat water is still done manually with human intervention. So that fishermen are preoccupied with removing puddles of boats and hindering their work. Based on the above problems, this study aims to make a traditional boat water drain control system automatically. This tool functions to control the volume of water in the boat as well as turn on and turn off the water pump engine automatically. This tool is able to remove puddles that enter the fishing boat automatically. The working principle of this tool, if the water hits the sensor ≥ 5 cm, the pump and buzzer will start and if the water doesn't hit the sensor, the pump and buzzer will automatically shut down.
Proposta de melhoria da qualidade com a implantação da metodologia Seis Sigma
Authors: Pinho Flávio Costa , Vilela Allan dos Santos , Barros José Glenio Medeiros de , Almeida Maria da Glória Diniz de , Sampaio Nilo Antonio de Souza , Silva José Wilson de Jesus
Published: October 2020

Este artigo tem como objetivo explorar, através de uma pesquisa bibliográfica de natureza qualitativa, os benefícios trazidos pela implantação da metodologia Seis Sigma que, por sua vez, tem como objetivo utilizar técnicas e ferramentas eficazes e eficientes para aprimorar melhorias em qualquer tipo de processo dentro de uma empresa. O Seis Sigma pode ser definido como uma estratégia gerencial disciplinada e altamente quantitativa com objetivo de aumentar drasticamente a lucratividade das empresas, por meio de melhoria da qualidade de produtos e processos e do aumento da satisfação de clientes e consumidores. Com a implantação da metodologia Seis Sigma a empresa consegue reconhecer, identificar oportunidades e problemas ligados com a estratégia corporativa que ajudem a reduzir custos, aumentar a produtividade e atacar questões para aumentar a eficiência de todas áreas, ou seja, todo processo pelo qual o produto fabricado passa até a etapa final.
Mental health of Brazilian physicians during the COVID-19 pandemic
Authors: Pimentel Déborah , Figueiredo Daniel Lima , Mattos Roberta Machado Pimentel Rebello de , Barreto Ikaro Daniel de Carvalho
Published: October 2020

Aim: To identify the profile of Brazilian doctors and the prevalence of mental suffering during the COVID-19 pandemic. Methods: This is a cross-sectional, exploratory quantitative study, performed between April and May 2020, using a sociodemographic questionnaire and a specific tool for tracking non-psychotic mental disorders: the Self Report Questionnaire. Results: Participant profile: women (68.1%), between 31 and 40 years old (39.9%), married or with partners (59.9%), without children (53.3%), with up to five years of graduation (30.9%), and working in public service (40.7%). The doctors (49.79%) show strong signs of mental suffering, with impaired sleep, headache, and psychotropic drug use. Many of them feel easily tired and have difficulty in satisfactorily carrying out daily activities. Many are tense, nervous or worried (77.4%); feel sad and are crying more than usual. Among them, 34.8% are losing interest in things, 14.6% feel they are useless, and 4.3% have suicidal thoughts. Conclusions: Almost half of the Brazilian doctors (49.79%) show strong signs of mental suffering, with a level of tension, nervousness and worry that affects more than half of the professionals. Ongoing programs for the prevention of mental disorders and suicide during and after the COVID-19 pandemic are required.
Influência da comunicação por meio de mensagens de texto na colaboração de pacientes jovens nas fases iniciais do tratamento ortodôntico
Authors: Costa Pedro Augusto , Conti Ana Cláudia de Castro Ferreira , Almeida-Pedrin Renata Rodrigues de , Volpato Graziela Hernandes , Ladewig Victor Miranda , Didier Victor França , Valarelli Danilo Pinelli
Published: October 2020

Objetivo: Avaliar a influência do envio de mensagens de texto via aplicativo de comunicação na colaboração de pacientes jovens com o tratamento ortodôntico. Uma amostra composta por 54 pacientes jovens em tratamento ortodôntico com média de idade de 14,7 anos, foi dividida em dois grupos de 27 pacientes sendo um grupo experimental (15,11 anos de idade +-2,69 anos) e outro controle (15,44 anos de idade +-2,69 anos). Mensagens semanais foram enviadas via aplicativo de comunicação WhatsApp, durante quatro meses, diretamente aos celulares dos pacientes do grupo experimental, incentivando-os a evitar descolagens de braquetes e tubos na fase inicial do tratamento ortodôntico. Ao final dos quatro meses, os grupos foram comparados quanto ao número de descolagens. Para comparação do número de pacientes que descolaram algum tubo ou braquete foi utilizado o teste exato de Fisher. Para a avaliação quanto ao número de descolagens, foi utilizado o teste do qui-quadrado. Adotou-se nível de significância de 5% (p<0,05). Resultados: Não houve diferença estatística significante entre os grupos, embora o número de descolagens tenha sido maior no grupo controle. Conclusão: o envio de mensagens via aplicativo não foi capaz de influenciar no número de descolagens quando comparados os grupos experimental e controle.
Distribuição vertical de fósforo no solo proveniente do superfosfato triplo
Authors: Rossi Ana Carolina Marinho , Kusano Daniel Makoto , Lopes Fernando de Souza , Silva Marcos Antonio Camacho da
Published: October 2020

O objetivo do presente trabalho foi estimar a taxa de movimentação vertical do fósforo proveniente do superfosfato triplo para solos de texturas arenosa, média e argilosa. O trabalho foi conduzido em vasos, irrigados diariamente com água destilada, dos quais 10 vasos foram preenchidos com solo de textura arenosa (Neossolo Quartzarênico), 10 com o de textura média (Latossolo Vermelho Distrófico) e 10 com o de textura argilosa (Argissolo Vermelho), em que, para cada grupo de dez vasos, 5 foram adubados com superfosfato triplo e 5 foram utilizados para controle (sem adubação). Estes vasos foram montados com canos de PVC de 150 mm, cortados a uma altura de 2 cm cada anel, cada vaso era composto de 10 anéis colados por fita adesiva. Para as análises foram utilizadas 300 amostras retiradas do centro de cada anel, que foram secas, cachimbadas e submetidas à análise de P pelo método Melich-1. O solo que teve melhor resposta à adubação foi o argiloso, enquanto que o arenoso e o de textura média mostraram pouca mobilidade do fósforo e, consequentemente, sua maior retenção nas camadas mais superficiais.
Profile of hypertensive and / or diabetic patients of a Basic Health Unit in Maranhão, Brazil
Authors: Costa Gabriela Oliveira Parentes da , Ribeiro Aclênia Maria Nascimento , Fernandes Catiane Raquel Sousa , Vieira Maria Clara Costa , Araújo Camilo José Soares , Santos Adriana de Medeiros , Oliveira Francisca das Chagas de Jesus Soares , Jansen Ricardo Clayton Silva , Lopes Michelle Kerin , Baldoino Luciana Stanford , Araujo Raquel Vilanova , Araújo Ana Danúsia Izidório Rodrigues de
Published: October 2020

Objective: to know the profile of hypertensive and / or diabetic patients treated at a basic health unit in Maranhão. Method: This is a descriptive, retrospective study with a quantitative approach, performed in April 2018, with data from medical records of 137 patients enrolled in the HIPERDIA program. Data were collected through a structured script and tabulated using the SPSS SamplePower Software. Results: in the researched unit there were 195 registered patients, hypertensive and / or diabetic. A higher number of female hypertensive and / or diabetic patients was observed, with a higher prevalence of these pathologies in individuals between 60 and 69 years, followed by those aged between 50 and 59. The predominant weight among participants was between 60 and 69kg. The main blood pressure values ​​found were <120/80 (45.99%) and with 140-159 / 90-99 (22.63%). Conclusion: weight gain is related to older age and it would be interesting to follow a nutritionist and a physical educator within the multiprofessional team in the basic health units, since both pathologies need weight control so that the rates remain stable. When prescribing medications, attention should be paid to protocols regarding the risks of drug interaction that exist among some antihypertensives.
Mortalidade materna: recorte temporal em um estado na Amazônia
Authors: Alberto Diovana de Sena , Maués Silvia Claudia Cunha , Cardoso Rosilene Ferreira , Meireles Antônio Alexandre Valente , Abreu Adalton da Costa , Silva Sandro Rogério Mendes da
Published: October 2020

Objetivo: O presente estudo objetiva analisar o perfil da mortalidade materna no estado do Amapá durante os anos de 2012 a 2016. Métodos: Trata-se de estudo descritivo com análise de dados a partir do Sistema de Informação sobre Mortalidade e Sistema de Informação sobre Nascidos Vivos, realizando-se cálculo da Razão de Mortalidade Materna (RMM). Resultados: No período, houve variação da RMM de 49 para 111 mortes por 100.000 nascidos vivos. Observou-se que 52,8% dos óbitos foram no puerpério; 100% foram classificados como evitáveis; no hospital (90,7%). Predominou-se a faixa etária de 30 a 39 anos, 43,1%; mulheres com ensino médio completo, 34,0%; solteiras, 53,4%; e da cor parda, 67,2%. Conclusão: Conclui-se que a mortalidade materna apresenta perfil crescente no estado, evidenciado por melhores pardas, entre 30 a 39 anos, solteiras, com ensino médio completo, cuja morte foi de causa evitável e direta, em parto cesáreo, no hospital. O perfil permite a orientação dos trabalhos da gestão, o cuidado dos profissionais da saúde e as ações da sociedade civil.
Nα-lauroyl-l-arginine ethyl ester monohydrochloride, an antimicrobial agent and its use: a review
Authors: Motta Joyce Fagundes Gomes , Ribeiro-Santos Regiane , Guimarães Maria Clara , Moura Lívia de Aquino Garcia , Vitorazi Letícia , Melo Nathália Ramos de
Published: October 2020

Growing demand for safe foods coupled with the intent to reduce food waste, seeing as much of it is lost through contamination by spoilage microorganisms, leads to research on antimicrobial agents such as LAE (Nα-lauroyl-L-arginine ethyl ester monohydrochloride). This compound has great antimicrobial potential against a range of microorganisms and, therefore, its use may be of extreme importance for the food industry in the search for antimicrobial agents with a broad spectrum of action. Thus, the objective of this article is to review the research involving LAE, when studied in vitro, in vivo and in the incorporation in different packaging in order to be released in a controlled manner for food products. In conclusion, despite the fact that it has a strong antimicrobial activity, it is still little known and is not accepted in all countries, including Brazil. With greater insight into this antimicrobial agent, more countries could use it, supporting worldwide in food preservation.
O câncer do colo uterino e o impacto psicossocial da radioterapia pélvica: revisão integrativa
Authors: Pimentel Natalia Beatriz Lima , Modesto Felipe Cardoso , Lima Vivian Cristina Gama Souza , Andrade Karla Biancha Silva de , Oliveira Adriana Maria de , Fuly Patrícia dos Santos Claro , Santos Mauro Leonardo Salvador Caldeira dos
Published: October 2020

Objetivo: Analisar as publicações a respeito do impacto psicossocial da radioterapia pélvica como modalidade de tratamento para o com câncer do colo uterino. Métodos: Revisão integrativa da literatura realizada nas bases de dados LILACS, Web of Science, MEDLINE/PubMed, CINAHL e Scopus através do cruzamento dos descritores: Neoplasias do Colo Uterino, radioterapia, impacto psicossocial, psico-oncologia, psicologia e seus respectivos sinônimos interligados pelo Operador Booleano AND, com recorte temporal dos últimos cinco anos. Resultados: Após a análise e síntese dos dados encontrados emergiram três categorias de significados: Qualidade de vida pós-radioterapia para o câncer de colo uterino; Disfunção sexual relacionada a radioterapia pélvica feminina e O Impacto do linfedema de membros inferiores no cotidiano da mulher. Considerações finais: O estudo demonstrou que o câncer de colo uterino afeta negativamente a qualidade de vida das mulheres, tanto no aspecto físico quanto emocional, na qual a disfunção sexual e o linfedema parecem estar atrelados.
Combining love and knowledge to heal the ocean
Authors: Lotze HK
Published: October 2020

Despite decades of management and conservation efforts, we have seen only limited success in rebuilding marine life and restoring ocean ecosystems from human-inflicted damage on a global scale. I suggest that we need to harness both our emotional (love) and rational (knowledge) sides to create a more powerful movement to heal the ocean and rebuild its abundance and diversity. Love and compassion fuel our desire and urge for change and provide a compass that can guide our actions. Science and knowledge provide ways for collecting and interpreting data and information that can enhance our understanding and support our decisions and actions. Combining our emotional and rational sides can inspire our thinking and transform our actions in new, creative ways. In order to affect wide-ranging and long-lasting change, love and knowledge need to work together to transform our collective relationship with the ocean.
Comparison of mesozooplankton production estimates from Saanich Inlet (British Columbia, Canada) using the chitobiase and biomass size spectra approaches
Authors: Kwong LE , Suchy KD , Sastri AR , Dower JF , Pakhomov EA
Published: October 2020

Zooplankton production estimates are necessary to understand the availability and transfer of energy to higher trophic levels in marine food webs. Methods have been developed to quantify zooplankton production; however, they are difficult to compare as they focus on single species, groups, stages, or size classes of zooplankton. We compared 2 methods for estimating crustacean production: the chitobiase method (based on a crustacean moulting enzyme), and 3 empirical growth rate models (Huntley-Lopez, Hirst-Lampitt, and Hirst-Bunker) applied to optically resolved mesozooplankton normalized biomass size spectra (NBSS). Mesozooplankton net samples were collected between March and August of 2010 and 2011 in Saanich Inlet (British Columbia, Canada) and analyzed in the laboratory using microscopy and a bench-top laser optical particle counter (lab-LOPC). Microscope and lab-LOPC estimates of abundance and biomass were in close agreement. Crustacean production estimates were highest using Huntley-Lopez (0.20-185.3 mg C m-3 d-1), followed by Hirst-Bunker (0 .01-18.3 mg C m-3 d-1), chitobiase (0.05-15.6 mg C m-3 d-1), and Hirst-Lampitt (0.03-14.3 mg C m-3 d-1). Hirst-Lampitt-, Hirst-Bunker-, and chitobiase-based estimates of crustacean production and trophic transfer efficiency (TTE) yielded similar patterns/magnitude, while the Huntley-Lopez model was more variable. Estimates showed stronger agreement in 2011 than in 2010, attributed to the shift from El Niño to La Niña conditions. We highlight similarities/differences associated with these techniques and suggest that Hirst-Bunker estimates of production and TTE are most consistent with chitobiase-based values.
PEMERIKSAAN RADIOLOGIS URETEROPELVIC JUNCTION OBSTRUCTION PADA ANAK
Authors: Muchtar Yarmaniani Miliati , Soeprijanto Bambang , Normahayu Indrastuti , Violetta Lenny
Published: October 2020

Ureteropelvic junction obstruction ( UPJO ) is the most common cause of hydronephrosis in children. Hydronephrosis caused by prolongedUPJO will damaged the kidneys. Early detection needed to avoid the complication. In fact, there are cases which is discovered in older child.Therefore it is necessary to carry out appropriate diagnostic steps and support the management of patients. Radiological examination usingvarious modalities can help diagnose UPJO.
PNEUMOTORAKS SPONTAN BILATERAL PADA PENYAKIT KISTA PARU
Authors: Tripriyanggara Ardhi , Harijanto Agus , Violetta Lenny , Soeprijanto Bambang
Published: October 2020

Diffuse Cystic Lung Disease (CLD) is rare and its etiology is unclear. This disease is more progressive if occurs in children. The frequent complications are pneumonia and pneumothorax. The management and prognosis of CLD is varied and difficult to predict. We report a caseof CLD in a child who had pneumonia and spontaneous pneumothorax. Although clinically improved after treatment and subsequentlytreated as outpatient, but bilateral pneumothorax is still present and chest tube is still inserted.
PEMERIKSAAN STATIC FLUID MAGNETIC RESONANCE UROGRAPHY PADA ANAK DENGAN DUGAAN OBSTRUKSI TRAKTUS URINARIUS
Authors: Rusli Nydia , Soeprijanto Bambang , Normahayu Indrastuti
Published: October 2020

Background : Static fluid Magnetic Resonance Urography (MRU) treats the urinary tract as a static column of fluid, using one of a variety of T2-weighted sequences that exploit the long T2 relaxation time of urine. It does not require the excretion of contrast material and is therefore useful for demonstrating the collecting system and ureter of an obstructed urinary tract. Static fluid MRU provides good morphology visualization and multiplanar three-dimensional reconstruction capability.

Aim of study : To display the excellence of static fluid MRU in visualization of dilatated urinary tract segments in pediatric cases with suspectedurinary obstruction.

Methods : Nine pediatric patients with suspected obstructive uropathy (as suggested by ultrasound) were included in this case study. The examinations were performed with 1.5T MR scanners using static fluid T2-weighted MRU sequence. Ultrasound examinations were done forall patients. Voiding cystourethrogram was done for 3 patients.

Results : Eight studied patients had dilated collecting systems. Static fluid MRU can provide detailed structural assessment of dilatatedcollecting systems. It was superior to ultrasound in evaluation of obstructive double collecting system, ureteral ectopia, ureteral obstructionand massive hydroureteronephrosis.
YOLK SAC TUMOR OVARIUM
Authors: Treswari Galuh Ayu , Soeprijanto Bambang , Normahayu Indrastuti , Violetta Lenny
Published: October 2020

Yolk sac tumor called endodermal sinus tumor, is a rare and very malignant germ cell tumor. The second largest ovarian germ cell tumor after dysgerminoma, with an incidence of 1% of ovarian malignancies. Tumors usually appear as fast-growing masses in young women. The radiological imaging of this tumor is seen as a large dense cystic mass with heterogeneous enhancement, a component of dilated intratumoralblood vessels accompanied by an intralesional hemorrhagic focus. The best radiological modality is CT scan or MRI. CT imaging useful for distinguishing yolk sac tumors from other ovarian tumors. In this article was reported a case of ovarial york sac tumor in 7 years old girl. USGand CT scan examination showed solid with cystic mass in the pelvic cavity. Histologically was malignant germ cell as york sac tumor.
TRAUMA GINJAL
Authors: Sulistia Noflih , Soeprijanto Bambang , Normahayu Indrastuti , Violetta Lenny
Published: October 2020

Renal trauma in children is more common than in adults. Clinically in pediatric patients with renal trauma do not always describe the degreeof trauma. Radiological examination, especially abdominal CT-scan with contrast, can help evaluate the damage to the kidneys so that it candetermine the degree of trauma.
The Reconstruction of The Corruption Eradication System in The Perspective of The Criminal Law in Indonesia
Authors: Cahyani Tinuk Dwi , Aunuh Nu'man
Published: October 2020

Corruption is a crime, just like all other crimes which has existed since a long time ago. The problem is that corruption is like a virus in the society which may spread very quickly. It is difficult to eradicate. The efforts to eradicate corruption has been carried out, but the reality shows that it keeps on increasing along with the increasing welfare, technologies, and development. On 2018, Indonesia stood in the 89th place of the world corruption rank. Thus, there needs to be a reconstruction to the forms of the main and the additional punishments in Indonesia’s positive law, so that it is clear that corruption is a terrible crime which must be fought using extraordinary methods. In Indonesia’s constitution of Corruption Eradication Article 2 clause 2 of the constitution No. 31 of 1999 it states that, “In the case of the crime of corruption as meant in clause (1), when carried out under certain conditions, death penalty may be imposed.” From the explanation of that article, and also from the Constitution No. 31 of 1999 it can be concluded that the forms of existing main punishments are: Imprisonment for some time or life sentence, death sentence, or fine. Meanwhile, the forms of additional punishments are: The revocation of certain rights, the deprivation of certain items, the announcement of the judge’s verdict, the deprivation of tangible movable properties (unmovable and intangible) which are used or are obtained from corruption, the payment of replacement money according to the amount obtained from corruption, the closing of some businesses for the maximum period of one year, and the revocation of all or some rights (the elimination of some privileges.

Keywords: reconstruction; corruption; criminal law
Wind Turbulence Statistics of the Atmospheric Inertial Sublayer under Near-Neutral Conditions
Authors: Lotfy Eslam Reda , Harun Zambri
Published: October 2020

The inertial sublayer comprises a considerable and critical portion of the turbulent atmospheric boundary layer. The mean windward velocity profile is described comprehensively by the Monin–Obukhov similarity theory, which is equivalent to the logarithmic law of the wall in the wind tunnel boundary layer. Similar logarithmic relations have been recently proposed to correlate turbulent velocity variances with height based on Townsend’s attached-eddy theory. The theory is particularly valid for high Reynolds-number flows, for example, atmospheric flow. However, the correlations have not been thoroughly examined, and a well-established model cannot be reached for all turbulent variances similar to the law of the wall of the mean-velocity. Moreover, the effect of atmospheric thermal condition on Townsend’s model has not been determined. In this research, we examined a dataset of free wind flow under a near-neutral range of atmospheric stability conditions. The results of the mean velocity reproduce the law of the wall with a slope of 2.45 and intercept of −13.5. The turbulent velocity variances were fitted by logarithmic profiles consistent with those in the literature. The windward and crosswind velocity variances obtained the average slopes of −1.3 and −1.7, respectively. The slopes and intercepts generally increased away from the neutral state. Meanwhile, the vertical velocity and temperature variances reached the ground-level values of 1.6 and 7.8, respectively, under the neutral condition. The authors expect this article to be a groundwork for a general model on the vertical profiles of turbulent statistics under all atmospheric stability conditions.
Preliminary Study on β3-Adrenoreceptor as Predictor Marker of Relapse in Ewing Sarcoma Patients
Authors: Calvani Maura , Vignoli Marina , Beltrami Giovanni , Pasha Amada , Scalini Perla , Mannurita Sara Ciullini , Cardellicchio Stefania , Coccoli Luca , Cecchi Cecilia , De Marco Emanuela , Luti Laura , Bernasconi Sayla , Filippi Luca , Casazza Gabriella , Tamburini Angela , Favre Claudio
Published: October 2020

Ewing sarcoma (EWS) is a paediatric aggressive malignant tumour of bones and soft tissues. Multidisciplinary chemotherapies, surgical resection, and radiation represent the only strategies counteracting the disease, however spreading and relapse of disease still remain a clinical issue. Circulating tumour cells (CTCs) are an important feature of EWS but the prognostic significance has not been, yet, clarified. CTCs have been found both in patients with localized disease and in those who recur or metastasize. The identification of markers that can detect recurrences and metastasis remains an important challenge for research. Unfortunately, even most of patients with localized cancer relapsed and the reason has not yet been fully understood. In this clinical study on EWS patients, we evaluated the expression of CD99 antigen and beta-3 adrenergic receptor (β3-AR) on CTCs and bioptic derived cells by flow cytometry. The preliminary data revealed a higher β3-AR expression on cells derived from metastatic or relapsed patients, suggesting a role for the β3-AR as a possible predictive maker of disease recurrence in both patients with metastatic and localized disease.
Genetic Alterations of Metastatic Colorectal Cancer
Authors: Testa Ugo , Castelli Germana , Pelosi Elvira
Published: October 2020

Genome sequencing studies have characterized the genetic alterations of different tumor types, highlighting the diversity of the molecular processes driving tumor development. Comprehensive sequencing studies have defined molecular subtypes of colorectal cancers (CRCs) through the identification of genetic events associated with microsatellite stability (MSS), microsatellite-instability-high (MSI-H), and hypermutation. Most of these studies characterized primary tumors. Only recent studies have addressed the characterization of the genetic and clinical heterogeneity of metastatic CRC. Metastatic CRC genomes were found to be not fundamentally different from primary CRCs in terms of the mutational landscape or of genes that drive tumorigenesis, and a genomic heterogeneity associated with tumor location of primary tumors helps to define different clinical behaviors of metastatic CRCs. Although CRC metastatic spreading was traditionally seen as a late-occurring event, growing evidence suggests that this process can begin early during tumor development and the clonal architecture of these tumors is consistently influenced by cancer treatment. Although the survival rate of patients with metastatic CRC patients improved in the last years, the response to current treatments and prognosis of many of these patients remain still poor, indicating the need to discover new improvements for therapeutic vulnerabilities and to formulate a rational prospective of personalized therapies.
Biomimetic Aspects of Oral and Dentofacial Regeneration
Authors: Upadhyay Akshaya , Pillai Sangeeth , Khayambashi Parisa , Sabri Hisham , Lee Kyungjun T. , Tarar Maryam , Zhou Stephanie , Harb Ingrid , Tran Simon D.
Published: October 2020

Biomimetic materials for hard and soft tissues have advanced in the fields of tissue engineering and regenerative medicine in dentistry. To examine these recent advances, we searched Medline (OVID) with the key terms “biomimetics”, “biomaterials”, and “biomimicry” combined with MeSH terms for “dentistry” and limited the date of publication between 2010–2020. Over 500 articles were obtained under clinical trials, randomized clinical trials, metanalysis, and systematic reviews developed in the past 10 years in three major areas of dentistry: restorative, orofacial surgery, and periodontics. Clinical studies and systematic reviews along with hand-searched preclinical studies as potential therapies have been included. They support the proof-of-concept that novel treatments are in the pipeline towards ground-breaking clinical therapies for orofacial bone regeneration, tooth regeneration, repair of the oral mucosa, periodontal tissue engineering, and dental implants. Biomimicry enhances the clinical outcomes and calls for an interdisciplinary approach integrating medicine, bioengineering, biotechnology, and computational sciences to advance the current research to clinics. We conclude that dentistry has come a long way apropos of regenerative medicine; still, there are vast avenues to endeavour, seeking inspiration from other facets in biomedical research.
Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans
Authors: Parker Clarissa C. , Lusk Ryan , Saba Laura M.
Published: October 2020

Alcohol use disorder (AUD) is a complex, chronic, relapsing disorder with multiple interacting genetic and environmental influences. Numerous studies have verified the influence of genetics on AUD, yet the underlying biological pathways remain unknown. One strategy to interrogate complex diseases is the use of endophenotypes, which deconstruct current diagnostic categories into component traits that may be more amenable to genetic research. In this review, we explore how an endophenotype such as sensitivity to alcohol can be used in conjunction with rodent models to provide mechanistic insights into AUD. We evaluate three alcohol sensitivity endophenotypes (stimulation, intoxication, and aversion) for their translatability across human and rodent research by examining the underlying neurobiology and its relationship to consumption and AUD. We show examples in which results gleaned from rodents are successfully integrated with information from human studies to gain insight in the genetic underpinnings of AUD and AUD-related endophenotypes. Finally, we identify areas for future translational research that could greatly expand our knowledge of the biological and molecular aspects of the transition to AUD with the broad hope of finding better ways to treat this devastating disorder.
Tracking Children’s Physical Activity Patterns across the School Year: A Mixed-Methods Longitudinal Case Study
Authors: Khawaja Irfan , Woodfield Lorayne , Collins Peter , Benkwitz Adam , Nevill Alan
Published: October 2020

Despite the breadth of health benefits associated with regular physical activity (PA), many children in the UK are not sufficiently active enough to meet health guidelines, and tend to become less active as they mature into and throughout adolescence. Research has indicated that children’s school, home and neighbourhood environments can all significantly influence their opportunities to engage in moderate-to-vigorous physical activity (MVPA). However, less is known about how children’s MVPA patterns within these key environments may change across the school year. The current mixed-methods case study aims to explore this issue by tracking key stage 2 (KS2) and key stage 3 (KS3) children’s MVPA patterns across the school year. Fifty-eight children (29 boys, 29 girls, KS2 = 34, KS3 = 24) wore an integrated global positioning systems (GPS) and heart rate (HR) monitor over four consecutive days in the first term of school (autumn), before these measurements were repeated in the two remaining school terms (winter–summer). A subsample of children (n = 6–8 per group) were invited to take part in one of six focus groups each term to further explore their PA behaviours and identify the barriers and facilitators to PA. The children’s MVPA was significantly lower (p = 0.046) in term 2 (winter/spring term) than during the warmer terms (autumn and summer). All the locations showed reductions in MVPA in term 2, except indoor MVPA, which increased, and MVPA on foot in the neighbourhood, which remained consistent. Focus groups revealed location, friends, and the variety of options to be associated with MVPA, and poor weather, parental permission, and time limitations to be barriers to MVPA. This mixed-methodological, repeated-measures design study highlights differences in the activity patterns and perceptions of children over the school year. Future studies should implement longitudinal, multi-method approaches to gain deeper insight into how children’s PA behaviours differ over time. Consequently, this can inform future health policies promoting children’s PA throughout the year.
Structural Variations in Manganese Halide Chain Compounds Mediated by Methylimidazolium Isomers
Authors: Han Ceng , Cordes David B. , Slawin Alexandra M. Z. , Lightfoot Philip
Published: October 2020

The structures of two new hybrid organic–inorganic manganese halide compounds [1MiH]MnCl3(H2O) and [4MiH]MnCl3(H2O) ([1MiH] = 1-methylimidazolium, [4MiH] = 4-methylimidazolium) have been determined by single crystal X-ray diffraction. Both are composed of one dimensional [MnCl3(H2O)]n− edge-sharing octahedral chains. The structures are compared to the previously reported isomeric analogue [2MiH]MnCl3(H2O) ([2MiH] = 2-methylimidazolium), and three closely related compounds. The variations in packing of the inorganic chains are shown to be influenced by hydrogen bonding abilities of the imidazolium or related moieties. Both new compounds show intense red luminescence at ambient temperature under UV irradiation.
Seascape Configuration and Fine-Scale Habitat Complexity Shape Parrotfish Distribution and Function across a Coral Reef Lagoon
Authors: Eggertsen Maria , Chacin Dinorah H , van Lier Joshua , Eggertsen Linda , Fulton Christopher J , Wilson Shaun , Halling Christina , Berkström Charlotte
Published: October 2020

Structural complexity spanning fine to broad spatial scales can influence the distribution and activity of key organisms within marine ecosystems. However, the relative importance of hard (e.g., corals) and/or soft (e.g., macroalgae) structural complexity for marine organisms is often unclear. This study shows how both broad-scale (seascape configuration of coral structure) and fine-scale habitat complexity (structure height, number of holes, and presence of macroalgae) can influence the abundance and spatial ecology of reef fish. Underwater visual census of fish, surveys of habitats, remote underwater videos, and behavioral observations by following individual fish were used to quantify fine-scale habitat characteristics (e.g., complexity, coral structure height, macroalgae presence) and the abundance, size structure, and behavior (rates of herbivory, tortuosity ratios and total distance travelled) of abundant parrotfish. Both seascape configuration and macroalgae influenced the patterns of fish abundance and rates of herbivory. However, these relationships varied with trophic groups and ontogenetic stages. Abundance of adult and intermediate-phase parrotfishes was positively influenced by densely aggregated coral structures, whereas juvenile abundance was positively influenced by the presence of macroalgae. Foraging path and bite rates of an abundant parrotfish, Chlorurus spilurus, were not influenced by coral structure configuration or height, but the presence of macroalgae increased the bite rates of all juvenile parrotfish. Our results suggest that a combination of seascape configuration, fine-scale habitat complexity, and microhabitat selectivity influence reef fish community structure and foraging behavior, thus altering herbivory. However, these relationships can differ among functional groups of fish and life-history stages. Information on these fish–habitat interactions is critical for identifying habitats that facilitate ecological functions and ensures the successful management and conservation of essential habitats.
Definition of Core Bacterial Taxa in Different Root Compartments of Dactylis glomerata, Grown in Soil under Different Levels of Land Use Intensity
Authors: Estendorfer Jennifer , Stempfhuber Barbara , Vestergaard Gisle , Schulz Stefanie , Rillig Matthias , Joshi Jasmin , Schröder Peter , Schloter Michael
Published: October 2020

Plant-associated bacterial assemblages are critical for plant fitness. Thus, identifying a consistent plant-associated core microbiome is important for predicting community responses to environmental changes. Our target was to identify the core bacterial microbiome of orchard grass Dactylis glomerata L. and to assess the part that is most sensitive to land management. Dactylis glomerata L. samples were collected from grassland sites with contrasting land use intensities but comparable soil properties at three different timepoints. To assess the plant-associated bacterial community structure in the compartments rhizosphere, bulk soil and endosphere, a molecular barcoding approach based on high throughput 16S rRNA amplicon sequencing was used. A distinct composition of plant-associated core bacterial communities independent of land use intensity was identified. Pseudomonas, Rhizobium and Bradyrhizobium were ubiquitously found in the root bacterial core microbiome. In the rhizosphere, the majority of assigned genera were Rhodoplanes, Methylibium, Kaistobacter and Bradyrhizobium. Due to the frequent occurrence of plant-promoting abilities in the genera found in the plant-associated core bacterial communities, our study helps to identify “healthy” plant-associated bacterial core communities. The variable part of the plant-associated microbiome, represented by the fluctuation of taxa at the different sampling timepoints, was increased under low land use intensity. This higher compositional variation in samples from plots with low land use intensity indicates a more selective recruitment of bacteria with traits required at different timepoints of plant development compared to samples from plots with high land use intensity.
A Discussion Regarding the Measurement of Ventilation Rates Using Tracer Gas and Decay Technique
Authors: Almeida Ricardo M. S. F. , Barreira Eva , Moreira Pedro
Published: October 2020

The measurement of ventilation rates is crucial in understanding buildings’ performances, but can be a rather complex task due to the time-dependency of wind and buoyancy forces, which are responsible for the pressure differences that induce air movement across the envelope. Thus, assessing air change rate through one-time measurements during brief periods of time may not be a reliable indicator. In this paper, the variability in the measurement of ventilation rates using the decay technique was evaluated. To that end, two compartments of a typical single-family detached dwelling were selected as a case study and 132 tests were performed, considering two different boundary conditions (door closed and door open). This work allowed the large variability of the results to be highlighted, as the coefficient of variation ranged from 20% to 64%. Wind speed had a key effect on the results, especially because during the measurements indoor–outdoor temperature differences were not so significant. The possibility of using occupant-generated carbon dioxide as tracer gas was also analyzed, but problems of cross-contamination were identified.
Comparing the Postoperative Outcomes of Single-Incision Laparoscopic Appendectomy and Three Port Appendectomy With Enhanced Recovery After Surgery Protocol for Acute Appendicitis: A Propensity Score Matching Analysis
Authors: Kim Won Jong , Jin Hyeong Yong , Lee Hyojin , Bae Jung Hoon , Koh Wooree , Mun Ji Yeon , Kim Hee Ju , Lee In Kyu , Lee Yoon Suk , Lee Chul Seung
Published: October 2020

Purpose: The objective of this study was to compare the perioperative outcomes between single-incision laparoscopic appendectomy (SILA) and 3-port conventional laparoscopic appendectomy (CLA) in enhanced recovery after surgery (ERAS) protocol.Methods: Of 101 laparoscopic appendectomy with ERAS protocol cases for appendicitis from March 2019 to April 2020, 54 patients underwent SILA with multimodal analgesic approach (group 1) while 47 patients received CLA with multimodal analgesic approach (group 2). SILA and CLA were compared with the single institution’s ERAS protocol. To adjust for baseline differences and selection bias, operative outcomes and complications were compared after propensity score matching (PSM).Results: After 1:1 PSM, well-matched 35 patients in each group were evaluated. Postoperative hospital stays for patients in group 1 (1.2 ± 0.8 vs. 1.6 ± 0.8 days, P = 0.037) were significantly lesser than those for patients in group 2. However, opioid consumption (2.0 mg vs. 1.4 mg, P=0.1) and the postoperative scores of visual analogue scale for pain at 6 hours (2.4±1.9 vs. 2.8 ± 1.4, P = 0.260) and 12 hours (2.4 ± 2.0 vs. 2.9 ± 1.5, P = 0.257) did not show significant difference between the 2 groups.Conclusion: SILA resulted in shortening the length of hospitalization without increase in complications or readmission rates compared to CLA with ERAS protocol.
FEATURES OF CRISIS MANIFESTATIONS IN FOREST COMPLEX OF THE RUSSIAN FEDERATION
Authors: Panyavina Ekaterina
Published: October 2020

Development trends of forestry enterprises indicate the presence of problems in their activities. The analysis of the activities and development of forestry enterprises and the forest industry made it possible to formulate a list of key problems holding back the development of the forest complex of the Russian Federation. Part of the problems relating to the internal environment, enterprises are able to solve independently, using, inter alia, government support measures. However, the problems associated with the external environment, the enterprises of the forest complex of the Russian Federation can not solve on their own. It has been determined that the existing regulatory legal acts and measures to stimulate the development of industry enterprises do not fully ensure the development of the forest complex and require substantial revision. The imperfection of the existing mechanism of interaction between forestry and the forest industry is proved. The identified problems of the forest complex contribute to the development of crisis manifestations. To ensure the sustainability of the forestry enterprises, taking into account the features of their functioning, directions are proposed for developing an effective model of state management of the forestry complex.
Beginning teacher induction program for technology integration in CLIL
Authors: Kwangsawad Thooptong
Published: October 2020

Beginning teacher induction is a transition from pre-service teacher preparation to teaching professional which brings a shift in a role orientation and an epistemological move from knowing about teaching through formal study to knowing how to teach by facing daily teaching challenges. This paper deals with the implementation and evaluation of beginning teacher induction programs for technology integration in Content and Language Integrated Learning (CLIL) for 24 beginning teachers from the northeastern region in Thailand. Both quantitative and qualitative data were collected. Quantitative data were collected from the assessment of the lesson plans and implementation of the lesson plans then analyzed using mean and standard deviation. Qualitative data were collected from three sources: (1) written logs by the participants, (2) data from video observation by the researcher, and (3) field notes by the researcher. Findings from the assessment of the lesson plans and implementation of the lesson plans were at a low level. Almost all participants reported having difficulties in technology integration in CLIL.
Metodología SOSTAC, una herramienta para la panificación de ventas digital: caso empresa “Trazos y Siluetas”
Authors: Suntasig Tenesaca Mayra Alexandra
Published: October 2020

El marketing digital se ha convertido en una estrategia de innovación tecnológica para que las empresas sean sostenibles en el tiempo, aseguren su supervivencia y crecimiento en el mercado. El objetivo del presente trabajo de investigación fue presentar un plan de ventas digital para la empresa“Trazos y Siluetas” basado en la metodología SOSTAC, uno de los modelos más populares de marketing por su facilidad para estructurar las campañas. La investigación es de tipo descriptiva basada en fuente bibliográfica documental. Se utilizó una muestra de 80 clientes a quienes se les aplicó unaencuesta semiestructurada denotando el desconocimiento de productos o servicios que oferta la empresa. Como parte de las conclusiones del trabajo se pudo evidenciar que es muy importante la planificación mediante una herramienta metodológica que permita marcar los objetivos de las empresas para su sostenibilidad en el tiempo.
Desarrollo de un template responsive para publicidad bajo la tecnología Zurb Foundation
Authors: Chica Armijos Luis Roberto
Published: October 2020

La maquetación responsive de un boletín para campañas publicitarias resulta poco eficiente si se realiza con herramientas no estandarizadas o CMS (Sistemas de Gestor de contenido), estas son orientadas a usuarios sin conocimientos de html (HyperText Markup Language) y de uso libre limitado; o laboriosos si se utiliza en cambio lenguaje nativo html, lo cual aumenta la complejidad del desarrollo debido a la cantidad de etiquetas que se deben incluir en toda la estructura del código; todo ello sumado a las restricciones que presenta cada cliente de correo electrónico al renderizar en html, lo que ocasiona generalmente problemas en la visualización del boletín y aumento en la carga operativa del desarrollo.

Este trabajo propone utilizar la herramienta Zurb Foundation para el desarrollo de un template responsive, esto permite disminuir la carga operativa del desarrollador, facilitando la escritura de código y la visualización de los cambios en un navegador web en tiempo real, con la certeza de que el boletín se visualice correctamente en los principales dispositivos móviles y clientes de correo electrónico.