bluuebunny/crossref_metadata_2025 huggingface dataset:
HOMENS AO PÚBLICO, MULHERES AO PRIVADO
Authors: Carvalho George Araújo , Pantoja Vanda
Published: September 2022

O presente artigo visa analisar a relação entre religão e política no engedramento do Plano Municipal de Educação (PME) da cidade de Imperatriz, no Sudoeste Maranhense. Esse engendramento resultou na “supressão”, no PME, de termos como “relações de gênero”, “identidade de gênero” e “diversidade sexual”. A metodologia se baseou em análise de documentos e legislações sobre educação básica, além de bibliografia sobre a relação entre agentes religiosos e políticos. Os resultados nos mostram que é possível afirmar a relação de interferência dos setores religiosos e políticos na esfera da educação, em especial, quando ela trata de questões sobre diversidade sexual, relações de gênero e identidade de gênero.
Współpraca gminy Uniejów i parafialnego stowarzyszenia „Spycimierskie Boże Ciało” z włoskim stowarzyszeniem „InfiorItalia” i jej znaczenie w kontekście spycimierskiej drogi do UNESCO
Authors: Owczarek Agnieszka
Published: September 2022

Koniec roku 2021 zapisał się w sposób szczególny w historii Spycimierza – 16 grudnia w Paryżu spycimierskie i opolskie kwietne dywany, układane na procesję Bożego Ciała, zostały oficjalnie wpisane na Listę reprezentatywną niematerialnego dziedzictwa kulturowego ludzkości UNESCO. Istotną rolę na drodze tych starań odegrało włoskie Stowarzyszenie „InfiorItalia”, z którym Spycimierz współpracuje od blisko dekady. Okoliczność wpisu na światową listę oraz jubileusz 20-lecia „InfiorItalii” przypadający na rok 2022 skłaniają do opisania współpracy między gminą Uniejów, stowarzyszeniem spycimierskim i „IniorItalią”, którą dziś można nazwać przyjaźnią, a także do scharakteryzowania po krótce obszaru działalności włoskiego stowarzyszenia oraz roli, jaką ono odegrało w kontekście spycimierskiej drogi do wpisu na listę niematerialnego dziedzictwa UNESCO.
Serum levels of VEGF-A, sVEGFR-2 and galectin-3 do not correlate with clinical stage, tumor size,
or effectiveness of perioperative chemotherapy in patients with non-metastatic breast cancer
Authors: Grochoła-Małecka Iga , Czajka-Francuz Paulina , Owczarek Aleksander , Wojnar Jerzy , Handzlik Gabriela , Francuz Tomasz , Chudek Jerzy
Published: September 2022

Wstęp

Angiogeneza nowotworowa jest procesem regulowanym przez wiele cytokin i czynników wzrostu, spośród których znaczącą rolę odgrywają czynnik wzrostu śródbłonka naczyń (vascular endothelial growth factor – VEGF), drugi rozpuszczalny receptor dla śródbłonkowego czynnika wzrostu (soluble vascular endothelial growth factor receptor 2 – sVEGFR-2) i galektyna-3. Dane literaturowe dotyczące oceny zmian stężenia VEGF, sVEGFR-2 oraz galektyny-3 w trakcie chemioterapii (chemotherapy – CTH) raka piersi (breast cancer – BC) są niejednoznaczne. Celem niniejszej pracy była analiza stężenia VEGF-A, sVEGFR-2 oraz galektyny-3 w surowicy pacjentek z rakiem piersi, rozpoczynających adjuwantową i neoadjuwantową chemioterapię oraz ocena zmian stężenia tych cytokin w trakcie leczenia.

Materiał i metody

Jednoośrodkowe badanie objęło 98 pacjentek z miejscowo zaawansowanym rakiem piersi, w tym 56 poddanych adjuwantowej i 42 neoadjuwantowej terapii. Stężenie VEGF-A, sVEGFR-2 i galektyny-3 w surowicy krwi oceniono na początku leczenia oraz po 2 miesiącach terapii.

Wyniki

Nie stwierdzono istotnych różnic pomiędzy stężeniami VEGF-A, sVEGFR-2 oraz galektyny-3 w surowicy pacjentek poddanych adjuwantowej i neoadjuwantowej chemioterapii. Nie wykazano również zależności między stężeniem tych cytokin w surowicy a stopniem zaawansowania klinicznego raka piersi. W trakcie przedoperacyjnej chemioterapii odnotowano znaczące zwiększenie stężenia VEGF-A, sVEGFR-2 i galektyny-3, jednakże zarówno wyjściowe stężenia cytokin, jak i zmiany w czasie nie miały znaczenia predykcyjnego dla uzyskania całkowitej odpowiedzi patologicznej.

Wnioski

Stężenia VEGF-A, sVEGFR-2 oraz galektyny-3 w surowicy nie korelują ze stopniem zaawansowania klinicznego ani masą nowotworu u pacjentek z miejscowo zaawansowanym rakiem piersi. Wyjściowe stężenia VEGF-A, sVEGFR-2 i galektyny-3 oraz zaobserwowany wzrost stężeń tych cytokin w surowicy w trakcie chemioterapii nie mają wartości predykcyjnej dla jej skuteczności.
ОЦЕНКА ЗАПАСА ДРЕВОСТОЕВ НА ЗЕМЛЯХ ЛЕСНОГО ФОНДА С УЧЕТОМ АНТРОПОГЕННЫХ РИСКОВ: ПРОГРАММНО-МЕТОДИЧЕСКОЕ ОБЕСПЕЧЕНИЕ
Authors: Лепихина Ольга Юрьевна , Демидова Полина Михайловна , Колесник Ольга Александровна , Ковязин Василий Фёдорович , Гурьева Ольга Сергеевна , Басова Лидия Алексеевна
Published: September 2022

Актуальность. Задача обеспечения автоматизированного учета, оценки и прогноза запаса лесных ресурсов является одной из важнейших направлений государственной стратегии развития лесного комплекса. Создание автоматизированной информационной системы по геодезическим данным, способной реализовывать качественный и полноценный информационный процесс по сбору, обработке, анализу, моделированию, прогнозу и визуализации пространственно-временных данных о состоянии лесных ресурсов с учетом основных рисков лесного хозяйства, является одним из важных механизмов повышения эффективности лесопользования. Цель: создание методического и программного обеспечения оценки запаса древесных ресурсов на землях лесного фонда с учетом антропогенных рисков. Объекты: лесные насаждения Чернореченского участкового лесничества Всеволожского лесничества Ленинградской области. Методы. На основе применения методов регрессионного моделирования получены математические модели зависимости запаса насаждений различных древесных пород от среднего возраста древостоя в лесном выделе; в основу разработанного программного обеспечения заложены авторские методические решения по оценке и прогнозу запаса древесины. Результаты. Применение полученных зависимостей для Чернореченского лесничества Всеволожского района Ленинградской области позволило рассчитать значения запаса древесины по состоянию на 2011 и 2021 гг., а также спрогнозировать его значения на 2031 г. Предложена методика оценки ущерба пожара на землях лесного фонда на основе интегрального показателя риска. Автоматизация расчета данного показателя в созданной программе позволила осуществить дифференциацию земель лесничества по трем классам риска пожаров. Сформирована карта зонирования территории объекта исследования по риску сплошных и самовольных рубок леса. Созданное программно-методическое обеспечение может служить основой для реализации одного из главных направлений стратегии развития лесного комплекса России в части создания единой федерально-информационной системы учета и прогноза текущего прироста запаса древесных ресурсов лесного фонда.
​Physiological and Biochemical Characters of Blackgram as Influenced by Liquid Rhizobium with Organic Biostimulants
Authors: Ajaykumar R. , Harishankar K. , Chandrasekaran P. , Kumaresan P. , Sivasabari K. , Rajeshkumar P. , Kumaresan S.
Published: September 2022

Background: The productivity of blackgram is not adequate to meet the domestic demand of the growing Indian population. Consequently, there is an urgent need for enhancement of productivity through proper management practices. With this background, a research experiment was conducted to investigate the effect of liquid rhizobium with organic bio-stimulants on physiological and biochemical characters, antioxidant enzymes and yield of blackgram. Methods: A field experiment was laid out in randomized block design with three replications during 2021 (Kharif and Rabi) season. The treatments include 100% recommended dose of NPK along with foliar application of dasagavya, liquid rhizobium, fish amino acid, panchagavya, pink pigmented facultative methylotrophs (PPFM) and Sea weed extract with different concentration (1% and 3%, respectively) in addition to control. Organic bio stimulants were sprayed at 30 and 45 days after the sowing of blackgram. Result: The experiment results revealed that the application of 100% RDF+Liquid Rhizobium @ 1% registered maximum physiological and biochemical characters viz., CGR, total chlorophyll content, soluble protein content, nitrate reductase activity, catalase activity, peroxidase activity and number of root nodules plant-1, yield attributes viz., number of pods plant-1, number of seeds pod-1, grain yield (kg ha-1), haulm yield (kg ha-1). Correlation and Regression analysis also indicated that the yield attributes had a positive impact on the grain yield.
Viruela en Colombia
Authors: Villamil Jiménez Luis Carlos , Sotomayor Tribín Hugo , Esparza José
Published: September 2022

Los hechos y personajes que lideraron la lucha contra la viruela en Colombia constituyen el aspecto central de este escrito. Temas como el cordón sanitario, el degredo, la variolización y la vacunación brazo a brazo, que se practicó desde 1804 con la llegada de la vacuna al país, son medidas que proceden de España; luego, se habla de la producción de la vacuna colombiana preparada en terneras en el laboratorio central, denominado Parque de Vacunación, donde además de eliminar los efectos adversos del brazo a brazo y se inició el desarrollo de protocolos que permitieron la obtención de una excelente vacuna, que sería utilizada en la prevención, el control y la erradicación temprana de la viruela en nuestro país.
Resignificar la educación
Authors: Vásquez Arreaga Jorge Daniel
Published: September 2022

Resignificar la educación constituye una propuesta que en este libro está articulada de tres maneras: epistemológica, cultural y política-pedagógica. En esta obra se desarrollan en el plano netamente conceptual, por cuanto se asume que hacer teoría es una forma de acción. La separación entre teoría y práctica se la dejamos a los que aún asumen que el dualismo es el trascendental filosófico desde el cual se comprenden todas los emprendimientos humanos. ¿Acaso es posible hablar de comunicación sin asumirse como sujeto de koiné ¿Es posible pensar la comunicación abstrayéndonos de nuestro ser-en-diálogo? Se parte de una respuesta negativa a estas preguntas para asumir la crítica en el plano conceptual, como un proceso que desencadena reflexiones que se extienden prolongadamente hasta el infinito o el ciberespacio. En las tres secciones de este libro se hallarán interlocutores distintos. En la primera están más presentes los que se podrían denominar teóricos y divulgadores del nuevo paradigma científico; en la segunda, los que se podrían denominar críticos del presente, y en la tercera, los que se podrían identificar como filósofos de la sociedad alternativa. El desafío es no entender los aportes como piezas superpuestas, sino como los hilos de un mismo tejido, lo cual, a su vez, significa que la tarea de hilvanar los tres hilos no es una operación acabada, sino que implica la voluntad de quien se acerca al texto con la pretensión de encontrar una experiencia compartida.
Guía para prácticas experimentales de física
Authors: Varela Muñoz Daniel Abdón , Bustamante Lozano Álvaro Mauricio , Dueñas Suaterna Jorge Alberto , Vinasco Téllez Mauricio
Published: September 2022

La presente guía recoge más de cuarenta años de experiencia en la enseñanza de la física dentro del contexto experimental universitario, cuyos propósitos y tendencias pedagógicas han evolucionado a la par con los avances tecnológicos en la medición y la computación. Por tal razón, las metas generales del texto son aproximar al estudiante a la praxis experimental en el ámbito de la física y reproducir dentro del proceso mismo de la mediación educativa una actitud similar a la manera rigurosa y exhaustiva con la cual un investigador profesional, ya en el campo de la ciencia, ejecuta su labor de indagación y generación de conocimiento, por supuesto, en su justa proporción.
Práctica y experiencia
Authors: Páez Martínez Ruth Milena
Published: September 2022

Dos motivos impulsaron este libro: 1. los maestros dedican poco tiempo a reflexionar y organizar sistemáticamente su misma experiencia pedagógica, a leer a otros colegas, a escribir, lo cual hace que pierdan posibilidades valiosas para crear nuevas formas de enseñanza y aprendizaje. 2. La necesidad de aportar dentro y fuera de la universidad un material que pueda ser referente en el trabajo pedagógico de las carreras de pregrado relacionadas con la educación, que favorezca ese diálogo de saberes entre maestros y maestros-estudiantes, y que brinde la posibilidad de leer-se-nos. En suma, esta publicación abre otro camino a la comprensión, a la reflexión y a la acción sobre la práctica y la experiencia pedagógicas como claves del saber pedagógico.
Families with high school children: the need for social assistance
Authors: Korchagina Irina , Prokofieva Lidia
Published: September 2022

Families with children in Russia have a high risk of poverty. Often mothers do not work in these families, and the income of working family members together with social support measures are not sufficient. In recent years, support for families with children has been priority of social policy. At the same time, the State social assistance depends on the age of a child, and as the child is growing older the social assistance is decreasing. Until 2021 the whole variety of monetary payments to children was limited to the age category of 7 years (for all families) and up to 17 years (for single-parent families). These age limits put other children at a disadvantage as compared to children receiving assistance. That's why in March 2022 the Government announced a monthly cash payment for all children living in low-income families aged from 8 to 17 years. The next age limit for children in low-income families getting social support leaves without benefits children aged 17-18 years. Usually they do not have their own income, but they require not less, but more family expenses for their maintenance. The main goal of the study was to show that families with children aged 16-17 bear the same expenses as families with children under 16 years of age, but they have no additional sources of income. The study was based on the data from a population survey (Household Budget Survey-2019) and a longitudinal survey of families with school-age children (Russian Longitudinal Monitoring Survey of HSE2018-2019). The study emphasized the need of social support for families with senior school-age children.
Features of population settlement in Orenburg oblast in the Ural River basin
Authors: Chibilyov Alexander , Meleshkin Dmitry , Grigorevsky Dmitry , Chibilyov Alexander
Published: September 2022

One of the most topical problems of economic and geographical study of the regions of the Steppe belt in Russia is the development of a network of rural settlements. The territory of the Ural River basin within Orenburg oblast, where more than 75% of the region's population lives, was chosen by the authors as a model to assess the transformation of the population settlement system in the Steppe zone in recent decades. The paper gives municipal and territorial characteristics of the region, identifies specifics of the current system of population settlement, and classifies rural localities depending on the population and spatial distribution over the studied territory. The main areas of population concentration along transport, communication and landscape axes are identified and considered. About 20% of settlements are concentrated along 5 major highways; more than 30% of localities are confined to the valleys of 7 major rivers. Engel and Goltz coefficients, population concentration indices are calculated for municipalities, and indicators of the potential of the settlement field are identified for their centers. A cartographic diagram reflecting the spatial distribution of rural localities, the dynamics of rural population density and the level of transport development of municipalities, is constructed. In the territory under consideration, there has been a decrease in the density of the rural population by 4% for the past 10 years. The following large rural localities have the maximal potential of the fields of settlement: Saraktash, Akbulak, Novoorsk, Ilek, Sakmara, Oktyabrskoye and Tyulgan. Along with the compression of space and its polarization, the population continues to decline in urbanized areas too. The population decreased by almost 60 thousand inhabitants in seven cities. Conclusions and proposals on the sustainable development of the settlement network in close cooperation between the development of the supporting and natural-ecological frameworks are formulated.
Associations and Statistical Inferences to the Productive Environment of the Oil Market: Analysis of the World’s Largest Producers from 1993 to 2020
Authors: Ferreira Rafael Henrique Mainardes , Rubbo Priscila , Picinin Claudia Tania
Published: September 2022

The energy matrix worldwide has been going through difficulties in its discussions - such as irregular exploration, inefficient public policies, and arbitrariness concerning diplomatic and political definitions of those involved in this market. This work's general objective consists in analyzing associations and statistical inferences of the largest world oil producers, assimilating the contributions and singularities of this market from 1993 to 2020. Based on the Organization of the Petroleum Exporting Countries (OPEC), it was possible to identify the possible inferences and contributions of the ten largest oil producers in the world in more than two decades using statistical analysis through correlation, regression, and statistical analysis of variables. According to the research and the literature on the area, the oil market proposes support to its discussions, mainly in its productive approaches. It is possible to identify this market as a solid link to geopolitical actions, distributing the possibilities through economic bias and socio-cultural and historical factors on a global level.
Seismic Signatures and Site Characterization of an Intermittent Stream in Dry and Flood Conditions: An Implication for Soil Losses and Landslide Triggering
Authors: Hussain Yawar Hussain , Seivane Helena , Qiangshan Gao , Maciel Susanne , Hamza Omar , Uagoda Rogério , Borges Welitom Rodrigues
Published: September 2022

The seasonal soil losses and frequent shallow landslides in the Cerrado region of Brazil have high destructive potential with social, economic, and climatic implications. As fluvial systems substantially drive such environmental threats; therefore, it is essential to conduct geological site characterization and continuously monitor the seasonal erosive potentials of the rivers and streams. However, in such unstable and sensitive conditions, traditional intrusive investigation approaches may not be safe; therefore, the geophysical investigation might offer a good alternative. For the present study, a geophysical approach (particularly the seismic method) was adopted to examine the seismic footprints and GPR site characterization of a seasonal stream in the Rua do Matto, Brasilia, Brazil. The monitoring was conducted (at a safe distance) on the intermittent stream over several durations of dry (no rain) and rainy (flood) conditions. After pre-processing the raw data, the power spectral density (PSDs) was computed as a function of several variables (wind speed), time-frequency spectrograms, ambient noise displacement root mean square (RMS), the single station horizontal-to-vertical spectral ratio (HVSR) curves. In addition, change-point analysis was used for comparing the ambient noise with wind speed (both were well correlated). The GPR amplitude and waveform variation features were attributed to the subsurface material and the presence of boulders in the floodplain as well as regions (low coherence value) susceptible to erosion (weak spots). The river flows were evident on the mean probabilistic PSD values, spectrograms, HVSR curves and different patterns of RMS displacements (at selective ranges of frequency). The multi-peaks emerged on the HVSR curve are further analyzed for changes in amplitude, width and troughs possibly related to river activities and soil moisture due to rain. The approach provides the basis for non-destructive monitoring tools enabling the detection of 'seismic signatures' and weak spots of the fluvial channels for improving their environmental management.
Nonlocality or Superposition? The Source of Quantum Contextuality
Authors: Mardari Ghenadie
Published: September 2022

Euclidean theorems are indisputable in flat spaces, but do not hold in curved spaces. Likewise, Bell’s Theorem is true for jointly distributed variables in Kolmogorov probability spaces. Yet, quantum spin variables are not jointly distributed and cannot coexist in Kolmogorov spaces. They have different qualities and operate by different rules. Therefore, Bell’s Theorem does not entail that quantum theory is non-local. The question remains: what is the origin of quantum contextuality? Other theories (not quantum theory) need nonlocality or super-determinism to make similar predictions, because they cannot violate Bell-type inequalities, but why is quantum theory different? The answer is found in the analysis of quantum superposition, in the context of a much older debate about the ontology of linear wave superposition.
The Commitment to Reducing Inequality Index 2022
Authors: Walker Jo , Martin Matthew , Seery Emma , Abdo Nabil , Kamande Anthony , Lawson Max
Published: September 2022

The 2022 Commitment to Reducing Inequality (CRI) Index is the first detailed analysis published looking at governments’ policies and actions to fight inequality during the first two years of the pandemic. This fourth edition of the CRI Index reviews the spending, tax and labour policies and actions of 161 governments during 2020–2022. COVID-19 has increased inequality worldwide, as the poorest people were hit hardest by both the disease and its profound economic impacts. Yet the CRI 2022 Index shows clearly that most of the world’s governments failed to mitigate this dangerous rise in inequality. Despite the biggest global health emergency in a century, half of low-and lower-middle-income countries saw the share of health spending fall during the pandemic, half of the countries tracked by the CRI Index cut the share of social protection spending, 70% cut the share of education spending, while two-thirds of countries failed to increase their minimum wage in line with gross domestic product (GDP). Ninety-five percent of countries failed to increase taxation of the richest people and corporations. At the same time, a small group of governments from across the world bucked this trend, taking clear actions to combat inequality, putting the rest of the world to shame. See also the CRI Index website: www.inequalityindex.org
A long time follow-up of the expanding bilateral sphenoid sinus plasty application in the treatment of refractory sphenoid sinusitis
Authors: Xue Fei , Yu Xiang , Cheng You , Wu Minghai , Ji Junfeng , Wang Zhiyi , Xu Li , Wang Rui
Published: September 2022

Background
The expanding bilateral sphenoid sinus plasty is an essential technique in the treatment of refractory sphenoid sinusitis. The aim of the present study was to explore the application of expanding bilateral sphenoid sinus plasty in the treatment of refractory sphenoid sinusitis.
Methods
Retrospective medical record review in a tertiary-care university hospital of 15 patients treated with the expanding bilateral sphenoid sinus plasty between December 2012 and December 2020. A follow-up of the surgical effect and complications were conducted. Primary outcomes evaluated were overall and disease-free survival. The end points assessed were presence of positive surgical margins, development of local, and regional recurrences.
Results
The patients were followed up for 12–73 months, with an average follow-up time of 28.5 ± 9.6 months. 15 cases of refractory sphenoid sinusitis were cured with well opened sphenoid sinus orifice and clean cavity. Of all the 15 cases, the symptoms were relieved after operation except preoperative hyposmia in 2 and impaired vision in one with no obvious improvement. No complications such as nasal bleeding, olfactory hypofunction and perforation of nasal septum occurred. Follow up revealed a better mucosal epithelization in all the patients within an average time of 8.6 weeks. Endoscopic sinus reexamination showed that the sphenoid sinus orifice was well opened, and no case of sphenoid sinus orifice closure was observed.
Conclusion
This study is a case series of a long time follow-up of the expanding bilateral sphenoid sinus plasty application in the treatment of refractory sphenoid sinusitis. With the advantages of easily intraoperative positioning, clearly exposed surgical field, full opening of sinus cavity, high surgical safety, short epithelialization time and intuitionistic postoperative follow-up, the expanding bilateral sphenoid sinus plasty is an improved way of treating refractory sphenoid sinusitis.
Implications:
This technique is worth being explored by surgeons for better surgical outcome.
Identification of Bactrian camel milk-related genes and regulatory networks in supplementation and grazing
Authors: Guo Lili , Lema Dao , Liu Bin , Dai Lingli , Wang Xue , Wang Xiaoshan , Cao Junwei , Zhang Wenguang
Published: September 2022

Using gene co-expression networks to understand dynamic characterizations in lactating animals becomes a common method. However, there are rarely reporters focusing on milk traits in Bactrian camel by high-throughput sequencing. We used RNA-seq to generate the camel transcriptome from the blood of 16 lactating Alxa Bactrian Camel in different feeding groups. In total, we obtained 1185 milk-related genes correlated with milk yield, milk protein, milk fat, and milk lactose across the WGCNA analysis. Moreover, 364 milk-related genes were differentially expressed between supplementation and grazing feeding groups. The DE-CMRGs in supplement directs an intensive gene co-expression network to improve milk performance in lactating camels. This study provides a non-invasive method to identify the camel milk-related genes in camel blood for four primary milk traits and valuable theoretical basis and research ideas for the study of the milk performance regulation mechanism of camelid animals.
AmPIF4 negatively regulates the blue light-induced synthesis of volatile terpenoids in snapdragon
Authors: Li Tong , Han Jianing , Wang Xuelian , Wu Jing , Leng Pingsheng , Hu Zenghui
Published: September 2022

Background
Floral secondary metabolites, especially terpenoids, play a key role in plant defense and reproduction. Terpenoids are the most abundant floral volatiles, and their synthesis and release are affected by light quality. Blue light can significantly enhance the emissions of terpenoids as well as the expression of biosynthesis-related genes in snapdragon. However, the regulatory mechanism of blue light-induced terpenoid biosynthesis remains unclear.
Results
In this study, the transcription factor (TF) PHYTOCHROME-INTERACTING FACTOR 4 (AmPIF4) was identified and found to be lowly expressed under blue light, which was in contrast to the expression of ocimene synthase (AmOCS) and myrcene synthase (AmMYS), 1-deoxy-D-xylulose 5-phosphate (DXP) synthase (AmDXS), and DXP reductoisomerase (AmDXR). AmOCS and AmMYS expression and the relative emissions of ocimene and myrcene were up-regulated in response to AmPIF4 silencing. Moreover, AmPIF4 negatively regulated terpenoid biosynthesis by binding to the promoters of biosynthesis-related genes. The transcriptional activation activity of AmPIF4 was increased in AmCRY1-silenced flowers. In addition, AmPIF4 interacted with AmCRYs (Cryptochromes) and AmCOP1 (CONSTITUTIVELY PHOTOMORPHOGENIC 1), which are key blue light signal receptors.
Conclusion
Overall, our results reveal a novel molecular mechanism involving AmPIF4 that contributes to the blue light-mediated regulation of terpenoid biosynthesis in snapdragon.
Haumanu Hauora: Refining public health institution policy to include Māori and climate change
Authors: Masters-Awatere Bridgette , Howard Darelle , Young Patricia
Published: September 2022

The deepening climate crisis generates specific impacts that will exacerbate the already disproportionately negative health outcomes experienced by Indigenous. These disparate health outcomes have not spontaneously emerged, but rather have been foreshadowed by existing inequities. This article summarises a sample of the work undertaken as part of a two-year research project inNew Zealand to understand existing policy processes and ascertain the extent to which health institutions give serious consideration to climate change impacts on health vulnerabilities of Māori (Indigenous people). Speaking to tāngata whenua (Indigenous Māori), rangatahi (Indigenous Māori youth) and District Health Board (DHB) employees it was clear that processes were ad hoc and problematically silenced consistent Māori input. Research participants expressed their experiences of, and aspirations for, dealing with climate change. Their voices were not evident in DHB policy processes. The deficit in existing policy process shows a lack of preparedness in the face of climate change. Despite clear resilience and adaptation strategies, structural change is needed to address identified disadvantages. Through a co-designed a policy framework (“Haumanu Hauora”) we guide policy formation to mitigate climate change risk to Māori (and others). Central to the revised policy framework is the introduction of a commissioning, refining and monitoring stage. Alongside the policy framework intervention points provide guidance to the newly developed health institutions. Five intervention points reflect the substantial work needed to develop Māori responsive policy in anticipation of climate change impacts. Above all, we believe that strengthening health institution responsiveness to Māori health needs is essential.
Modelling of corrosion rate in the drinking water distribution network using Design Expert 13 software
Authors: Kumar Saurabh , Singh Reena , Maurya Nityanand Singh
Published: September 2022

This study focused on the modelling of corrosion rate of the water distribution network of Patna, (Bihar), India using Design Expert 13 software. A total of nine variables, including pH, temperature, total dissolved solid (TDS), alkalinity, calcium hardness, chloride, sulphate, dissolved oxygen (DO), and time, were considered for modelling. The physicochemical parameters were determined through regular monitoring of water samples. The corrosion rate was determined by direct monitoring of water distribution pipes using adjustments of seven GI coupons for 45, 90, 135, 180, 225, 270, and 315 days. Modelling was performed using the low level and high-level experimental range for pH, temperature, TDS, alkalinity, calcium hardness, chloride, sulphate, DO, and time were 7.28, 23, 430, 115, 24, 18, 10.94, 3.5, 0 and 7.86, 28, 704, 284, 180, 98, 38.7, 6.8, and 315, respectively. Using the Box-Behnken design (BBD), 160 runs were conducted, including ten replicates at the central point of each block. The results of ANOVA indicate that values of R2, adjusted R2, and predicted R2 are 0.9714, 0.9507, and 0.8941, respectively. The value of R2 (0.9714) was close to 1, which indicates a good fit. The adequate precision was found to be 30.8442, indicating a good signal. A coefficient of variance discusses reproducibility, and in this case, it was 9.90%. On the basis of the ANOVA result, the quadratic model is well-fit and can be accepted as a suitable model. A total of seven parameters such as chloride, sulphate, hardness, alkalinity, pH, calcium, and hardness were used for the design of the experimental corrosion rate (CR). These individual CR vs. synthetic aqueous solutions were used to validate the interaction of the response surface. It was found that the trend of individual corrosion rates in synthetic aqueous solutions and the interaction of composite variables with corrosion rates in a quadratic model of response surfaces were clearly correlated.
Contamination status of paralytic shellfish toxins in shellfish from Southeastern China in 2017–2021
Authors: Zheng Renjin , Yang Yafang , Zhang Wenting , Hua Yongyou
Published: September 2022

A total of 2,355 shellfish samples were analyzed by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to study the toxin profiles of the 10 paralytic shellfish toxins (PSTs) collected from the southeast coast of China from 2017 to 2021. From 2355 shellfish samples (10.91%), 257 were detected, with the highest value in samples of Perna viridis. Among the six source areas in China, the samples from Fujian recorded the highest detected rate (15.28%). PSTs were found in Fuzhou (FZ), Ningde (ND), Quanzhou (QZ), Putian (PT), Zhangzhou (ZZ), and Xiamen (XM), with QZ and FZ having the highest and lowest detection rates of 15.28% and 4.23%, respectively. Saxitoxin (STX), neosaxitoxin (neoSTX), gonyautoxin (GTX1, GTX2, GTX3, GTX4), N-sulfocarbamoyl toxin (GTX5), and decarbamoyl toxin (dcSTX, dcGTX2, dcGTX3) were detected, and GTX5 and dcGTX2 were dominant. In addition, the samples containing PSTs were mostly concentrated in May to August and occasionally detected in December. The findings of this study will serve as a solid foundation for detecting marine contaminants and preserving seafood consumers’ health.
A qualitative exploration of the experiences of peer leaders in an intervention to improve diabetes medication adherence in African Americans
Authors: Tarfa Adati , Nordin Jenna , Mott Mattigan , Maurer Martha , Shiyanbola Olayinka
Published: September 2022

Background: African Americans chronically managing their diabetes benefit from receiving support from peers with shared experiences. Peer support is known to improve the well-being of individuals receiving support, however, there is limited literature on the experiences of those providing the support. The Peers Supporting Health Literacy, Self-efficacy, Self-Advocacy, and Adherence (Peers LEAD) program pairs Peer Ambassadors who are adherent to their diabetes medication, with Peer Buddies who need support with their medication adherence. Peer Ambassadors engage with Peer Buddies as they receive diabetes information, develop the skills and motivation to address identified psychosocial/sociocultural issues to enhance their diabetes medication adherence. This study qualitatively explores the experiences of African Americans who provided peer support in the Peers LEAD medication adherence intervention.
Methods: Two focus groups were conducted with twelve Peer Ambassadors to explore their experiences of providing peer support in the Peers LEAD medication adherence intervention. Qualitative content analysis was conducted using an inductive open coding approach.
Results: Emergent themes provided insight into Peer Ambassador’ rationale for providing peer support and the benefits and challenges they experienced in their roles. Themes regarding their rationale included: their desire to receive support for their diabetes self-management as well as to contribute to their communities in reducing the stigma associated with diabetes. The perceived benefits they gained centered on creating interpersonal connections, experiencing personal growth as they adapted to their roles, and experiencing opportunities to contribute to an intervention regardless of professional training. Peer Ambassadors reflected on the challenges which included difficulties on coming to terms with their role as Peer Ambassadors, seeing African Americans experience complications associated with diabetes, and navigating supporting Peer Buddies who are also burdened with the challenges their family members are experiencing with managing their diabetes.
Conclusions: This study provides unique insight to what motivates individuals to provide peer support and what they gain from these experiences despite challenges. Understanding the experiences of peers participating in such interventions may help inform the structure and content of programs that use peer support to focus on the benefits of and the motivation for participating in the program.
Multi-omics assisted breeding for biotic stress resistance in soybean
Authors: Bisht Ashita , Saini Dinesh Kumar , Kaur Baljeet , Batra Ritu , Kaur Sandeep , Kaur Ishveen , Jindal Suruchi , Malik Palvi , Sandhu Pawanjit Kaur , Kaur Amandeep , Gill Balwinder Singh , Wani Shabir Hussain , Kaur Balwinder , Mir Reyazul Rouf , Sandhu Karansher Singh , Siddique Kadambot H.M
Published: September 2022

Biotic stress is a critical factor limiting soybean growth and development. Soybean responses to biotic stresses such as insects, nematodes, and fungal, bacterial, and viral pathogens are governed by complex regulatory and defense mechanisms. Next-generation sequencing has availed research techniques and strategies in genomics and postgenomics. This review summarizes the available information on marker resources, quantitative trait loci, and marker trait associations involved in regulating biotic stress responses in soybean. We discuss the differential expression of related genes and proteins reported in different transcriptomics and proteomics studies and the role of signaling pathways and metabolites reported in metabolomic studies. Recent advances in omics technologies offer opportunities to reshape and improve biotic stress resistance in soybean by altering gene regulation and/or other regulatory networks. We recommend using ‘integrated omics’ to understand how soybean responds to different biotic stresses. We discuss the potential challenges of integrating multiomics for functional analysis of genes and their regulatory networks and the development of biotic stress-resistant cultivars. This review will help direct soybean breeding programs to develop resistance against different biotic stresses.
Application of IMMF-IHHT algorithm to suppressing random interference of geomagnetic sensors
Authors: zhang pingan , gao min , wang wei , wang yi , xujun su
Published: September 2022

Aiming at the problem that the geomagnetic sensor is vulnerable to external interference in the navigation process, this paper analyzes the frequency distribution range of geomagnetic signal and the noise characteristics in geomagnetic signal, and proposes an improved morphological filtering and Hilbert-Huang transform (IMMF-IHHT) algorithm to extract and recognize the features of geomagnetic measurement signal. To avoid frequency aliasing and distortion caused by empirical mode decomposition, an improved morphological filtering algorithm based on mean constraint is used to preprocess the measured signal. The Hilbert spectrum of the decomposed signal is solved, the signal components are discriminated by the similarity criterion, and the signal components in line with the frequency range of the geomagnetic signal are extracted and processed to reconstruct the geomagnetic measurement signal. Simulation and experiments show that the Signal-to-Noise Ratio (SNR) and Root Mean Square Error (RMSE) of IMMF-IHHT combination algorithm are better than MF-HHT combination algorithm and IHHT algorithm. This algorithm has good signal feature extraction and recognition ability.
Effects of Branched-Chain Amino Acids on Patients Undergoing Hepatic Intervention: A Meta-Analysis of Randomized Controlled Trials
Authors: Hsu Yan-Mei , Kuan Hui-Chung , Chen Yu-An , Chiu Ching-Wen , Chen Po-Cheng , Tam Ka-Wai
Published: September 2022

BACKGROUND: The benefits of branched-chain amino acid (BCAA) administration after hepatic intervention in patients with liver diseases remains unclear. We conducted a systematic review and meta-analysis to evaluate the effects of BCAA on patients undergoing hepatectomy, trans-arterial embolization, radiofrequency ablation.
METHODS: Relevant randomized controlled trials (RCTs) were obtained from PubMed, EMBASE, and Cochrane Library databases. A meta-analysis was performed to calculate the pooled effect size by using random-effects models. The primary outcomes were survival, hospital stay, nutrition status, and biochemistry profile. The secondary outcomes were the complication rate of liver treatment and adverse effect of BCAA supplementation.
RESULTS: In total, 11 RCTs involving 750 patients were included. Our meta-analysis showed no significant difference in the rates of tumorrecurrence and overall survival between the BCAA and control groups. However, the pooled estimate showed that BCAA supplementation in patients undergoing hepatic intervention significantly increased serum albumin (mean difference [MD]: 0.11 g/dL, 95% confidence interval [CI]: 0.02–0.20) at 6 months and cholinesterase level (MD: 50.00 U/L, 95% CI: 21.08–78.92) at 12 months, increased body weight (MD: 3.29 kg, 95% CI: 1.07–5.50) at 12 months, and reduced ascites incidence (risk ratio: 0.39, 95% CI: 0.21–0.71) compared with the control group. Additionally, BCAA administration shortened the hospital stay length (MD: −2.36 days, 95% CI: −4.78 to 0.07) compared with the control group.
CONCLUSION: BCAA supplementation significantly reduced postintervention complication and hospitalization duration and increased body weight. Thus, BCAA supplementation may benefit patients undergoing liver intervention.
Target selection for mid-high temperature geothermal exploration based on AHP and PCA: A case study of Jiangxi Province, China
Authors: LI Xuan , HUANG Changsheng , Chen Wei , Wang Xianguang , Bai Ximin , Yin Zhibin , Li Xiaozhe , Han Jihong
Published: September 2022

Jiangxi Province is located in the tropical zone of mid-high temperature geothermal resources along the southeastern coast of China. Geothermal geological surveys, the exposed natural hot springs, the explored geothermal walls and the reported geothermal research results related to the potential of geothermal energy indicate the abundant geothermal resources and the high formation potential of mid-high temperature geothermal resources in Jiangxi Province. However, the research level of geothermal resources in this area is relatively low, the distribution of geothermal hotspots is uneven, and the specific resource distribution, geothermal temperature, and resource quantity are not well understood, so it is difficult to systematically carry out the mid-high geothermal development in this province. Therefore, we collect the data of the study area, established a multi-index evaluation model combining experience and data, and carried out the evaluation of geothermal resources advantageous target areas and the analysis of geothermal impact indicators. The main purpose of this study is to use analytic hierarchy process (AHP) and principal component analysis (PCA) to qualitatively and quantitatively evaluate the mid-high temperature geothermal resources of the Jiangxi Province, and also to propose a dual-method comparative evaluation model for the study of the mid-high geothermal target area. Based on the quantitative data from geological, hydrological and geophysical sources and the extensive experience of regional workers and geologists, by using the AHP and PCA, we divide the study area into 7 geothermal resource potential zones and 38 geothermal optimal target areas. It is determined that deep large faults are the most critical indicators affecting the distribution of geothermal resources in the study area, followed by the heat storage value of the silicon enthalpy equation and the magmatic rocks. This study is of great significance for geothermal research in similar areas, multi-index and multi-data model analysis, and accurate positioning of high-quality geothermal resource target areas. It also has important guiding significance for the follow-up development planning of geothermal resources the research area or further research on the geothermal target area.
Heterogeneous changes of soil microclimate in high mountains and glacier forelands
Authors: Marta Silvio , Zimmer Anaïs , Caccianiga Marco , Gobbi Mauro , Ambrosini Roberto , Azzoni Roberto Sergio , Gili Fabrizio , Pittino Francesca , Thuiller Wilfried , Provenzale Antonello , Ficetola Gentile Francesco
Published: September 2022

Landscapes nearby glaciers are disproportionally affected by climate change, still we lack the information on microclimate variation that is required to understand impacts of climate change on these ecosystems and their biodiversity. Here we use near-subsurface soil temperatures in 175 stations from polar, equatorial and alpine glacier forelands to reconstruct temperatures at high resolution, assess spatial differences in microclimate change from 2001 to 2020, and estimate whether microclimate heterogeneity might buffer the severity of warming impacts on organisms. Temporal changes in microclimate are tightly linked to broad-scale trends, but the rate of global warming showed spatial heterogeneity, with faster warming nearby glaciers and during the warm season, and an extension of the snow-free season. Still, the fine-scale spatial variability of microclimate is one-to-ten times larger than the temporal change experienced, indicating the potential for microclimate to buffer climate change, possibly allowing organism to withstand, at least temporarily, the effects of warming.
Blockchain based robust Cooperative spectrum sensing
Authors: Ezhilarasi Evelyn , Clement Christopher , Thangavel Gunasekaran
Published: September 2022

The authors have requested that this preprint be removed from Research Square.
Three-dimensional Reverse Modeling and Hydraulic Analysis of the Intake Structure of Pumping Station on Sediment-laden Rivers
Authors: Xu Cundong , Tian Junjiao , Liu Zijin , Wang Rongrong , Wang Guoxia
Published: September 2022

For many pumping stations that draw water from sediment-laden rivers, the flow patterns in their intake structure are disordered due to sediment deposition, which seriously threatens the safe operation of projects. In order to accurately construct the complex and refined three-dimensional (3D) geometric model of the intake structure, and further explore the hydraulic characteristics of the water-sediment two-phase flow inside, this paper proposes a reverse modeling method and carries out numerical simulation. A typical forward intake structure in the arid region of Northwest China is selected as the research object. According to the point cloud data of the intake structure obtained by the 3D laser scanner, the curved surface models are rebuilt and imported into ICEM-CFD for improvement, thereby obtaining the 3D computational domain model of the actual intake structure; after lossless docking with FLUENT, the hydraulic characteristics are analyzed by applying the Realizable k-ε turbulence model coupled with the Mixture multiphase flow model considering interphase slip; finally, the reliability of the simulation is verified by in-situ flow measurements. Results demonstrate that the method can precisely reflect the actual geometric boundary and siltation of intake structure, and the numerical model can accurately identify the two-phase flow; the siltation improves the local flow field structure of the forebay to some extent, but cause the loss of the overall hydraulic performance of the intake structure. This study can provide a scientific reference for the geometric model construction and hydraulic analysis of intake structures with complex boundary and sediment deposition.