bluuebunny/crossref_metadata_2025 huggingface dataset:
MicroRNA ame-let-7 targets Amdop2 to increase sucrose sensitivity in honey bees (Apis mellifera)
Authors: Liu Fang , Zhao Hongxia , Li Qiang , Wu Lixian , Cao Dainan , Zhang Yuan , Huang Zachary Y.
Published: December 2023

Background

As an important catecholamine neurotransmitter in invertebrates and vertebrates, dopamine plays multiple roles in the life of the honey bee. Dopamine receptors (DA), which specifically bind to dopamine to activate downstream cascades, have been reported to be involved in honey bee reproduction, division of labour, as well as learning and motor behaviour. However, how dopamine receptors regulate honey bee behavior remains uninvestigated.

Results

The expression level of Amdop2 in the brain increased with the age of worker bees, which was just the opposite trend of ame-let-7. Inhibition of ame-let-7 through feeding an inhibitor upregulated Amdop2 expression; conversely, overexpression of ame-let-7 through a mimic downregulated Amdop2. Moreover, knockdown of Amdop2 in forager brain led to significantly higher sucrose responsiveness, which is similar to the phenotype of overexpression of ame-let-7. Finally, we confirmed that ame-let-7 directly targets Amdop2 in vitro by a luciferase reporter assay.

Conclusions

ame-let-7 is involved in the dopamine receptor signaling pathway to modulate the sucrose sensitivity in honey bees. Specifically, it down-regulates Amdop2, which then induces higher responses to sucrose. These results further unraveled the diverse mechanisms of the dopamine pathway in the regulation of insect behavior.
Smoother: a unified and modular framework for incorporating structural dependency in spatial omics data
Authors: Su Jiayu , Reynier Jean-Baptiste , Fu Xi , Zhong Guojie , Jiang Jiahao , Escalante Rydberg Supo , Wang Yiping , Aparicio Luis , Izar Benjamin , Knowles David A. , Rabadan Raul
Published: December 2023

Spatial omics technologies can help identify spatially organized biological processes, but existing computational approaches often overlook structural dependencies in the data. Here, we introduce Smoother, a unified framework that integrates positional information into non-spatial models via modular priors and losses. In simulated and real datasets, Smoother enables accurate data imputation, cell-type deconvolution, and dimensionality reduction with remarkable efficiency. In colorectal cancer, Smoother-guided deconvolution reveals plasma cell and fibroblast subtype localizations linked to tumor microenvironment restructuring. Additionally, joint modeling of spatial and single-cell human prostate data with Smoother allows for spatial mapping of reference populations with significantly reduced ambiguity.
Comparative proteomic analysis of wall-forming bodies and oocyst wall reveals the molecular basis underlying oocyst wall formation in Eimeria necatrix
Authors: Wang Lele , Liu Dandan , Zhu Yu , Wang Feiyan , Cai Weimin , Feng Qianqian , Su Shijie , Hou Zhaofeng , Xu Jinjun , Hu Junjie , Tao Jianping
Published: December 2023

Background

The durable oocyst wall formed from the contents of wall-forming bodies (WFBs) protects Eimeria parasites from harsh conditions and enhances parasite transmission. Comprehending the contents of WFBs and proteins involved in oocyst wall formation is pivotal to understanding the mechanism of the oocyst wall formation and the search for novel targets to disrupt parasite transmission.

Methods

Total proteins extracted from WFBs and the oocyst wall of Eimeria necatrix were subjected to comparative proteomic analysis using tandem mass tag in conjunction with liquid chromatography tandem-mass spectrometry techniques. After functional clustering analysis of the identified proteins, three proteins, including E. necatrix disulfide isomerase (EnPDI), thioredoxin (EnTrx) and phosphoglycerate kinase (EnPGK), were selected for further study to confirm their potential roles in oocyst wall formation.

Results

A total of 3009 and 2973 proteins were identified from WFBs and the oocyst wall of E. necatrix, respectively. Among these proteins, 1102 were identified as differentially expressed proteins, of which 506 were upregulated and 596 downregulated in the oocyst wall compared to the WFBs. A total of 108 proteins, including compositional proteins of the oocyst wall, proteases, oxidoreductases, proteins involved in glycosylation, proteins involved in synthesis of the acid-fast lipid layer and proteins related to transport, were proposed to be involved in oocyst wall formation. The approximate molecular sizes of native EnPDI, EnTrx and EnPGK proteins were 55, 50 and 45 kDa, respectively. EnPDI was present in both type 1 and type 2 WFBs, EnTrx was present only in type 2 WFB2 and EnPGK was present only in type 1 WFBs, whereas all of them were localized to the outer layer of the oocyst wall, indicating that all of them participate in the formation of the oocyst wall.

Conclusions

To the best of our knowledge, this is the first report on the proteomes of WFBs and the oocyst wall of E. necatrix. The data obtained from this study form a basis for deciphering the molecular mechanisms underlying oocyst wall formation of Eimeria parasites. They also provide valuable resources for future studies on the development of novel therapeutic agents and vaccines aimed at combating coccidian transmission.

Graphical Abstract
[18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma
Authors: Iversen Peter , Kramer Stine , Ebbehoj Andreas , Søndergaard Esben , Stochholm Kirstine , Poulsen Per Løgstrup , Hjorthaug Karin
Published: December 2023

Background

Both [18F]FDOPA (FDOPA) and [68Ga]DOTATOC PET/CT (DOTATOC) are widely used for detection of pheochromocytomas/paraganglioma (PPGL). However, direct comparisons of the performance of the two tracers are only available in small series. We conducted a retrospective comparative analysis of FDOPA and DOTATOC to assess their sensitivity and accuracy in detecting PPGL when administered based on suspicion of PPGL. We consecutively included patients referred on suspicion of PPGL or PPGL recurrence who were scanned with both FDOPA and DOTATOC. Both scans were reviewed retrospectively by two experienced observers, who were blinded to the final diagnosis. The assessment was made both visually and quantitatively. The final diagnosis was primarily based on pathology.

Results

In total, 113 patients were included (97 suspected of primary PPGL and 16 suspected of recurrence). Of the 97 patients, 51 had pheochromocytomas (PCC) (in total 55 lesions) and 6 had paragangliomas (PGL) (in total 7 lesions). FDOPA detected and correctly localized all 55 PCC, while DOTATOC only detected 25 (sensitivity 100% vs. 49%, p < 0.0001; specificity 95% vs. 98%, p = 1.00). The negative predictive value (100% vs. 63%, p < 0.001) and diagnostic accuracy (98% vs. 70%, p < 0.01) were higher for FDOPA compared to DOTATOC. FDOPA identified 6 of 6 patients with hormone producing PGL, of which one was negative on DOTATOC. Diagnostic performances of FDOPA and DOTATOC were similar in the 16 patients with previous PPGL suspected of recurrence.

Conclusions

FDOPA is superior to DOTATOC for localization of PCC. In contrast to DOTATOC, FDOPA also identified all PGL but with a limited number of patient cases.
Reduction of the toxin microcystin-LR with different types of sediments
Authors: Herrera Natalia , Florez Maria Teresa , Echeverri Fernando
Published: December 2023

Microcystis aeruginosa blooms in water bodies, evidencing a high risk of exposure to human health due to the release of toxins, which affects water quality. Implementing physical, chemical, and microbial control methods requires an integrated understanding of cyanotoxin dynamics, especially their relationship with sediments. Consequently, sediment obtained from three stations of the Riogrande II reservoir (Antioquia, Colombia) was analyzed to determine the adsorption and removal capacity of the microcystin-LR (MC-LR). For this purpose, the sediment was subjected to different treatments to select the one with the highest MC-LR removal capacity. Furthermore, the effectiveness and stability of adsorption removal process were evaluated by analyzing mechanical processes such as aeration, sonication, and agitation. The dried sediment showed the highest reduction in toxin concentration (93%) after 24 h, followed by washed sediment (91%) and sterilized sediment (81%).

On the other hand, the sediment was fractionated into silts and clays; the latter was the least effective. Finally, the fine and half silts were better adsorbents of the toxin, acting similarly over time. Initially, the utilization of sediment that has been dried by sunlight could be a complementary alternative to reinforce MC-LR control methodologies in water bodies.

On the one hand, MC-LR desorption assays showed that aeration of the sediment for 30 min caused a release of up to 96% of the adsorbed compound. At the same time, the effect of sonication and agitation was less intense. However, the absorption process must be fast to avoid efficiency losses due to desorption since a high percentage of the toxin was spontaneously desorbed from the sediment in two days.
Impact of depression and the potential effect of its treatment on semen parameters
Authors: El-Khateeb Ekramy A. , Mohamed Nada M. S. , Ghobrial Phoebe F. , El-Husseiny Rania M.
Published: December 2023

Background

Up to 30% of male infertility may be idiopathic. Researchers are looking into psychological problems, particularly depression, as possible risk factors for such idiopathic etiology. We aimed to assess how depression affects Egyptian patients’ semen parameters and its indicators for male fertility and to evaluate the potential positive influence of improving the score of depression on these parameters. A prospective observational pilot clinical study included twenty-one male patients with moderate, severe, or very severe depression. They were subjected to baseline semen analysis. All patients were treated by serotonin and norepinephrine reuptake inhibitors (SNRIs). Those who showed improvement in their depression, within the following 6 months, were eligible for a second evaluation of their semen. We compared baseline semen parameters of all patients to 2021-WHO lower normal limit as well as post-improvement values.

Results

Only 16 patients showed improvement in their depression after treatment with SNRIs and were candidates for the 2nd assessment of semen analysis. No significant improvements could be detected except for volume. Yet, on repeating the comparisons including only patients with abnormal baseline semen parameters, significant improvements were observed in most semen parameters, including semen volume, sperm count per ejaculate, and percentage of sperm motility either progressive or total.

Conclusion

The results addressed the potential impact of depression on male fertility in a sample of Egyptian patients through a negative effect on semen parameters. This effect is neither sole nor direct and may require either predisposed individuals or the existence of other co-factors to be manifested. However, the appropriate treatment of depression may reverse such effects and help in the management of male infertility.
Stay Black and Die
Authors: Durham I. Augustus
Published: December 2023

In Stay Black and Die, I. Augustus Durham examines melancholy and genius in black culture, letters, and media from the nineteenth century to the contemporary moment. Drawing on psychoanalysis, affect theory, and black studies, Durham explores the black mother as both a lost object and a found subject often obscured when constituting a cultural legacy of genius across history. He analyzes the works of Frederick Douglass, Ralph Ellison, Marvin Gaye, Octavia E. Butler, and Kendrick Lamar to show how black cultural practices and aesthetics abstract and reveal the lost mother through performance. Whether attributing Douglass's intellect to his matrilineage, reading Gaye's falsetto singing voice as a move to interpolate black female vocality, or examining the women in Ellison's life who encouraged his aesthetic interests, Durham demonstrates that melancholy becomes the catalyst for genius and genius in turn is a signifier of the maternal. Using psychoanalysis to develop a theory of racial melancholy while “playing” with affect theory to investigate racial aesthetics, Durham theorizes the role of the feminine, especially the black maternal, in the production of black masculinist genius.
Investimento em startup de inovação científica oriunda da academia
Authors: Santos Levindo
Published: December 2023

Caso de ensino sobre uma das primeiras startups brasileiras de base científica, oriunda da academia. A empresa dedica-se à produção de filmes finos nanoestruturados (coatings) destinados ao tratamento de distintos materiais, com potencial de aplicação em variados segmentos da indústria. O caso transcorre durante a primeira década deste século, quando a Nanox se preparava para receber um aporte de capital de um fundo de VC de capital semente. O objetivo central do caso é discutir os riscos e as articularidades envolvidas no desenvolvimento de empresas inovadoras oriundas da academia, sob a perspectiva tanto dos empreendedores quanto dos investidores financeiros.
Συγκεντρωτικά στοιχεία για τη φοίτηση μαθητών στα τμήματα ένταξης της πρωτοβάθμιας και δευτεροβάθμιας εκπαίδευσης μεταξύ των ετών 2017-2021
Authors: Παπαδημητρίου Βασίλειος
Published: December 2023

Οι μαθητές που φοιτούν στα τμήματα ένταξης κατά κύριο λόγο συνεργάζονται με ειδικές παιδαγωγούς που εφαρμόζουν προγράμματα παρέμβασης μέχρι 15 ώρες την εβδομάδα (κοινό και εξειδικευμένο πρόγραμμα) σε αίθουσα εκτός της γενικής τάξης, ενώ ένα μικρό ποσοστό υποστηρίζεται περισσότερες από 15 ώρες εβδομαδιαίως (πρόγραμμα διευρυμένου ωραρίου). Ο τύπος του προγράμματος καθορίζεται από τον επίσημο κρατικό φορέα που πραγματοποιεί τη διάγνωση. Επιπλέον, η ισχύουσα νομοθεσία επιτρέπει να εγγράφονται στα τμήματα ένταξης και μαθητές χωρίς επίσημη διάγνωση (Νόμος 3699/2008). Η εργασία αυτή αρχικά μελέτησε τον αριθμό των μαθητών με ή χωρίς διάγνωση στα τμήματα ένταξης των δύο βαθμίδων εκπαίδευσης τα σχολικά έτη 2017-2021. Έπειτα εξέτασε τον αριθμό των μαθητών με ή χωρίς διάγνωση που παρακολουθούσαν είτε κοινό και εξειδικευμένο πρόγραμμα είτε πρόγραμμα διευρυμένου ωραρίου. Όλα τα ποσοτικά δεδομένα χορηγήθηκαν από το Υπουργείο Παιδείας και Θρησκευμάτων. Τα αποτελέσματα κατέδειξαν και στις δύο βαθμίδες σημαντική μείωση τη διετία 2019-2021 στον συνολικό αριθμό (με ή χωρίς διάγνωση) όσων παρακολουθούσαν τα τμήματα ένταξης αλλά και στον αριθμό των μαθητών που παρακολουθούσαν κοινό και εξειδικευμένο πρόγραμμα. Τέλος, όσον αφορά τα προγράμματα διευρυμένου ωραρίου, στην πρωτοβάθμια εκπαίδευση υπήρξε σημαντική μείωση τη διετία 2019-2021, ενώ στη δευτεροβάθμια εκπαίδευση παρατηρήθηκε διακύμανση στη διάρκεια της τετραετίας. Τα ευρήματα εγείρουν προβληματισμό για την εξέλιξη των τμημάτων ένταξης που έχουν εσφαλμένα χαρακτηριστεί βασικός πυλώνας της ενταξιακής εκπαιδευτικής πολιτικής στην Ελλάδα.
Μεταβάσεις της πρωτοσχολικής ηλικίας στην ψηφιακή εποχή: Συνέχειες και ασυνέχειες στις πρακτικές γραμματισμού
Authors: Αποστόλου Ζωή
Published: December 2023

Η παρούσα εργασία παρουσιάζει τα αποτελέσματα έρευνας που αφορά τις δυνατότητες και τις προοπτικές του ψηφιακού μαθησιακού περιβάλλοντος για τη διασφάλιση της εκπαιδευτικής και μαθησιακής συνέχειας. Συγκεκριμένα, μελετώνται οι απόψεις των εκπαιδευτικών πρωτοσχολικής ηλικίας για τις πρακτικές γραμματισμού που έλαβαν χώρα στην προσχολική εκπαίδευση κατά τη διάρκεια της πανδημίας στο πλαίσιο των ψηφιακών τάξεων. Οι απόψεις για τις πρακτικές αυτές ιδωμένες στο συγκείμενο διασφάλισης των συνθηκών συνέχειας των προγραμμάτων για την ομαλή μετάβαση των παιδιών από το νηπιαγωγείο στο δημοτικό σχολείο διερευνώνται με τη χρήση της ποιοτικής μεθόδου έρευνας, με ημιδομημένες συνεντεύξεις σε νηπιαγωγούς και δασκάλους της πρώτης τάξης του δημοτικού σχολείου. Τα αποτελέσματα της έρευνας έδειξαν ότι νηπιαγωγοί και δάσκαλοι συγκλίνουν ως προς την άποψη ότι η συνέχεια του προγράμματος νηπιαγωγείου και δημοτικού σχολείου δε φαίνεται να μπόρεσε να υποστηριχτεί από τις νηπιαγωγούς την περίοδο της εξ αποστάσεως εκπαίδευσης. Αν και οι νηπιαγωγοί, αποπειρώμενες να προσεγγίσουν ισόρροπα διάφορες εμπειρίες προφορικού λόγου, ανάγνωσης και γραφής, με πρακτικές ικανές να διατηρήσουν το νήμα της συνέχειας από τη μια βαθμίδα στην άλλη, δε φαίνεται να είχαν τα προσδοκώμενα αποτελέσματα στο πλαίσιο της ψηφιακής τάξης. Τέλος, τα ευρήματα της παρούσας εργασίας υποδεικνύουν την ανάγκη διεύρυνσης της έρευνας, προκειμένου να αναδειχθούν πρακτικές ενίσχυσης του γραμματισμού στην κρίσιμη πρωτοσχολική ηλικία και δη στο πλαίσιο ιδιαίτερων εκπαιδευτικών συνθηκών, όπως είναι αυτή της ψηφιακής εποχής που διαμορφώθηκε εξαιτίας της πανδημίας Covid-19.
Αποτελεί η αυτοαξιολόγηση των σχολικών μονάδων το όχημα για την επαγγελματική ευημερία των νηπιαγωγών;: Απόψεις εκπαιδευτικών
Authors: Κουντζόγλου Άννα-Σπυριδούλα , Κακανά Δόμνα-Μίκα
Published: December 2023

Η παρούσα εργασία έχει σκοπό να διερευνήσει τις απόψεις των νηπιαγωγών αναφορικά με τη διαδικασία της αυτοαξιολόγησης των σχολικών μονάδων και τη σύνδεσή της με την επαγγελματική τους ευημερία. Η συγκεκριμένη θεματική περιοχή αξίζει ερευνητικής δραστηριότητας αφού πρόκειται για ένα εξαιρετικά επίκαιρο θέμα για την ελληνική εκπαίδευση αλλά κι ένα πεδίο το οποίο δεν έχει μελετηθεί επαρκώς στην Ελλάδα, ειδικά για την προσχολική εκπαίδευση. Με τη χρήση ημι-δομημένων συνεντεύξεων αντλήθηκαν οι απόψεις νηπιαγωγών για το θέμα. Οι νηπιαγωγοί του δείγματος ήταν 15, προερχόμενοι από διαφορετικές περιοχές της Ελλάδας. Προκειμένου να αναλυθούν τα δεδομένα χρησιμοποιήθηκε η μέθοδος της θεματικής ανάλυσης. Τα αποτελέσματα έδειξαν ότι οι περισσότεροι εκπαιδευτικοί τάσσονται υπέρ της αυτοαξιολόγησης των σχολικών μονάδων, αναφερόμενοι σε πολλές από τις διαστάσεις που χρήζουν αξιολόγησης. Σύμφωνα με τις νηπιαγωγούς του δείγματος, τα άτομα που θα πρέπει να εμπλέκονται σε αυτή τη διαδικασία είναι κυρίως οι ίδιοι οι εκπαιδευτικοί, η σχολική ηγεσία, καθώς και οι γονείς. Εντόπισαν επίσης αρκετά οφέλη της αυτοαξιολόγησης τόσο στους ίδιους όσο και στη σχολική μονάδα. Τέλος, το σύνολο των νηπιαγωγών ανέφερε την συνεργασία και την επικοινωνία με τους/τις συναδέλφους/-ισες ως τον πιο σημαντικό παράγοντα που επιδρά στην επαγγελματική τους ευημερία και μπορεί να επηρεαστεί από την αυτοαξιολόγηση της σχολικής τους μονάδας.
Πατέρες παιδιών με εγκεφαλική παράλυση και οικογενειακή λειτουργία
Authors: Τσιμπιδάκη Ασημίνα
Published: December 2023

Η εργασία πραγματεύεται την οικογενειακή λειτουργία όπως την αξιολογούν οι πατέρες που μεγαλώνουν ένα παιδί με εγκεφαλική παράλυση (ΕΠ) στην Ελλάδα και την Ιταλία. Ειδικότερα, εξετάζει το πώς νοηματοδοτούν την ΕΠ και την πατρότητα καθώς και τα χαρακτηριστικά και τις βασικές παραμέτρους (συνοχή, προσαρμοστικότητα, τύπος οικογένειας) της οικογενειακής λειτουργίας. Συμμετείχαν συνολικά 60 πατέρες (30 Έλληνες και 30 Ιταλοί) ηλικίας 28 έως 59 ετών. Για τη συλλογή των δεδομένων χορηγήθηκαν ένα Ερωτηματολόγιο Κοινωνικό-δημογραφικών Στοιχείων, η Κλίμακα Εκτίμησης Προσαρμοστικότητας και Συνοχής στην Οικογένεια και μια Ημι-δομημένη Συνέντευξη. Τα αποτελέσματα ανέδειξαν ότι οι πατέρες στην Ελλάδα και την Ιταλία είχαν ποικίλες νοηματοδοτήσεις για την ΕΠ, με κυρίαρχη αυτήν που τη θεωρεί ένα ιατρικό πρόβλημα, το οποίο επηρεάζει όλη την οικογένεια. Οι πατέρες παρουσίασαν κοινά βιώματα και εμπειρίες για τη λειτουργία της οικογένειας και ανέφεραν θετικά και αρνητικά χαρακτηριστικά της οικογενειακής λειτουργίας. Η πλειονότητα των πατέρων βρέθηκε να αξιολογεί και να επιθυμεί έναν ισορροπημένο τύπο οικογένειας και αυτό ανήκει στην υγιή οικογενειακή λειτουργία, σύμφωνα με την αναθεωρημένη έκδοση του Μοντέλου Κυκλικής Συνθετότητας. H μελέτη διαπιστώνει ότι οι πατέρες είχαν μεν ποικίλες και διακριτές νοηματοδοτήσεις για την ΕΠ και την οικογενειακή λειτουργία, ωστόσο, οι νοηματοδοτήσεις αυτές αξιολογούνται ως λειτουργικές και αυτό συνιστά έναν προστατευτικό παράγοντα για όλο το οικογενειακό σύστημα.
Protocol and statistical analysis plan for a randomized controlled trial of the effect of intravenous iron on anemia in Malawian pregnant women in their third trimester (REVAMP – TT)
Authors: Harding Rebecca , Moya Ernest , Ataíde Ricardo , Truwah Zinenani , Mzembe Glory , Mhango Gomezgani , Demir Ayşe V. , Stones William , Randall Louise , Seal Marc , Johnson Katherine , Bode Stefan , Mwangi Martin N. , Pasricha Sant-Rayn , Braat Sabine , Phiri Kamija S.
Published: December 2023

Background Anemia affects 40% of pregnant women globally, leading to maternal mortality, premature birth, low birth weight, and poor baby development. Iron deficiency causes over 40% of anemia cases in Africa. Oral iron supplementation is insufficient for Low-and-Middle-Income-Countries (LMICs) to meet current WHO targets. We hypothesized that a single intravenous dose of Ferric Carboxymaltose (FCM) may be more effective than oral iron treatment for anemia recovery, particularly in these settings where women present late for antenatal care. Methods This is a two-arm parallel open-label individual-randomized controlled trial in third trimester, in malaria Rapid Diagnostic Test-negative pregnant women with moderate or severe anemia - capillary hemoglobin <10 g/dL – who are randomized to receive either parenteral iron – with FCM – or standard-of-care oral iron for the remainder of pregnancy. This is the sister trial to the second-trimester REVAMP trial, funded by the Bill and Melinda Gates Foundation (trial registration ACTRN12618001268235, Gates Grant number INV-010612). In REVAMP-TT, recruitment and treatment are performed within primary health centers. The trial will recruit 590 women across Zomba district, Malawi. The primary outcome is the proportion of anemic women - venous hemoglobin <11 g/dL - at 36 weeks’ gestation or delivery (whichever occurs first). Other pre-specified key secondary clinical and safety outcomes include maternal iron-status and hypophosphatemia, neonate birth weight, infant growth and infant iron and hematological parameters. Discussion This study will determine whether FCM, delivered within primary health centers, is effective, safe and feasible for treating moderate to severe anemia in third-trimester pregnant Malawian women. This intervention could have long-term benefits for maternal and child health, resulting in improved survival and child development.
HANDWRITTEN SIGNATURE RECOGNITION USING NEURAL NETWORKS
Authors: Pyataeva Anna V. , Merko Mikhail A. , Zhukovskaya Vladislava A. , Pinchuk Ivan A. , Eliseeva Maria S.
Published: December 2023

This work is devoted to solving the problem of signature recognition using neural networks. The authors proposed the use of convolutional neural networks to determine the signature class. Signatures play an important role in financial, commercial and legal transactions, their recognition guarantees the security of not only information, but the whole person. The use of neural networks for signature recognition allows you to reliably identify a user in an automated mode. The authors have developed a convolutional neural network, and also proposed an algorithm that consists of image preprocessing, including background segmentation, noise reduction, and image normalization. Image preprocessing improves the quality of the network. Next, feature extraction is performed, which consists of global features, such as the ratio of the height to width of the signature, the maximum horizontal histogram and the maximum vertical histogram, the horizontal center and the vertical center of the signature, the endpoints of the signature, the signature area, training a neural network with extracted features, recognition the owner of the handwritten signature and then predicting the class of the signature.

Purpose – development of a handwritten signature recognition algorithm using neural networks.

Methodology: the methods of computer vision were used in the work; deep learning methods, as well as object-oriented programming methods.

Results: developed a handwritten signature recognition algorithm using a neural network.

Practical implications: the application of the results obtained is useful in forensic analysis of documents, since a person uses a signature on a regular basis to sign checks, legal documents, contracts and other paper media that need protection. Therefore, when someone tries to copy a signature, a problem arises that can lead to undesirable consequences in the form of theft and further use of both personal data and other valuable secret information.
MODEL FOR CALCULATING THE OPTIMAL OCCUPANCY OF CONTAINER TRAINS IN TWENTY-FOOT EQUIVALENT
Authors: Sheverdova Maria V. , Poliektov Dmitry A. , Yazev Denis V. , Smirnov Sergey S.
Published: December 2023

Objective: to develop a mathematical model for calculating the normative, actual and deficit values in twenty–foot equivalent (hereinafter referred to as DFE) in a given container train (hereinafter referred to as KP), to formulate an algorithm for calculating DFE in KP.

Methods: calculations using the Excel software environment were used in the segment of calculating the occupancy rate of a container train in the TEU, the percentage of occupancy compared to the standard value of the TEU.

Research results: based on the results of the work, a methodology for calculating the DFE in the KP was formulated, a mathematical model for calculating the twenty-foot equivalent of a given container train was developed.

Practical significance: it has been revealed that a new element in the calculations of the container train parameter should be considered the automatic calculation of the values of DFE (normative, actual, deficit values) for the entire container train (and not on a separate platform car) with the display of such important parameters as the number of wagons in the composition, the total number of containers loaded on wagons. A step-by-step description of the processes of calculating the DFE of a given composition of KP is performed. As a result of the research, a software product for calculating KP occupancy rates is proposed.
METHODOLOGY OF EMPIRICAL RESEARCH OF SOCIAL RESPONSIBILITY AND VALUE ORIENTATIONS OF STUDENTS
Authors: Kokurina Olga Yu. , Burov Alexander S.
Published: December 2023

The empirical study is aimed at determining the life values and goals of Russian students in the context of solving the problem of ensuring national sovereignty as a sphere of responsibility of the state and a factor in the formation of a new world order. This empirical study is a structural part of the study “Sovereignty and responsibility of the Russian state in the context of the formation of a new world order”, as well as a continuation of the studies “Political and legal mechanisms for ensuring the sustainability of socio-political systems” and “Factors of sustainable development of Russian statehood in the context of modern global challenges” .
Nobel Laureates in Economics in the 21st century: in 3 volumes.
Authors: Hudokormov Aleksandr , Sadygova N.K. , Vereshko Anna , Islamova Ya.A. , Maslov G.A. , Kruk N.A. , Hrabrovskaya Valeriya , Vasilyuk Aleksandr , Naumkin V.A. , Timerbulatova Kamilla
Published: December 2023

Volume 2 includes articles dedicated to the laureates of the Nobel Prize in Economics for 2008-2016: P. Krugman, E. Ostrom, P. Diamond, K. Pissarides, T. Sargent, K. Sims, L. Shepley, E. Roth, Y. Fama, L.P. Hansen, R. Shiller, J. Tyrol, A. Deaton, O. Hart and B. Holstrom. The biographies of scientists, their main ideas are considered, and their contribution to the development of economic theory is evaluated.
For students of economic universities and anyone interested in economic theory and the history of economic thought.
The Role of Non-Financial Reporting in Economic Decision-Making
Authors: Bychkova Svetlana , Mal'ceva E.
Published: December 2023

An important aspect of making an economic decision is the disclosure of both financial and non-financial information. Non-financial reporting is the main tool for obtaining the necessary information for stakeholders. Th e purpose of this work is to study the role of non-financial reporting in economic decision-making. The main stakeholders of the information presented in non-financial reporting have been identified. Th e analysis of the impact of non-financial reporting on economic decision-making by both internal and external users is carried out.
Using clustering methods to analyze sales of auto parts at a truck service station
Authors: Evdokimova Svetlana , Novikova Tatyana , Novikov Arthur
Published: December 2023

Clustering methods are widely used to divide goods into groups depending on sales volumes in order to build an optimal purchasing planning and inventory management strategy. Cluster analysis methods do not provide an unambiguous partition of the original set of objects, therefore, in the work, existing clustering methods were analyzed to study sales of auto parts at truck service stations. To solve the problem, the following methods were chosen: k-means, hierarchical agglomerative clustering and DBSCAN. Before using the k-means method, the elbow method found the optimal number of clusters. The DBSCAN method is based on object density and automatically determines the number of clusters. The initial data for cluster analysis was information on sales of spare parts at truck service stations for 3 years; clustering was applied to data by year. The DBSCAN algorithm showed unsatisfactory results, since most of the goods (86%) were identified in one cluster, while others contained units of goods. The k-means method gave the best partitioning result, each group has a different volume. The distribution of goods in clusters changes over three years, so managers should study the change in the affiliation of goods to one group or another. The obtained clustering results will help determine the real needs of spare parts at truck service stations and build an optimal procurement strategy.
Methodology and algorithm for calculating of local pressure losses in pipelines
Authors: Akimenko Andrey , Anikeev Evgeniy , Medvedev Roman
Published: December 2023

The article is devoted to the hydraulic calculation of pipelines. For the storage of liquid products used in the national economy, there are tanks, which are usually combined into tank farms. Equipment for transporting liquids within the tank farm includes pumping units, pipelines, shut-off and control devices, etc. The growing needs of the economy create the necessity of build new and expand existing storage facilities for liquid products at industrial and transport objects. Hydraulic calculation is an important part of the tank farms pipeline systems design. This paper presents a methodology and algorithm for determining of local fluid pressure losses in pipelines. The calculation is based on the characteristics of pipeline system sections in which local hydraulic resistance occurs: a change in the diameter or direction of the pipeline, installation locations of auxiliary devices, etc. The Weisbach formula is used to calculate the local pressure losses. This takes into account the values of the local resistances coefficients and average flow velocities in the respective sections. The average flow velocities are determined by the given values of the flow rates and flow profiles on the sections. The local losses coefficients, depending on the type of resistance, are also found according to the calculation formulas, or are set as the initial values. Local pressure losses are calculated for curved sections of pipelines, conical transitions (confusers and diffusers), inlet and outlet sections, shut-off, control and safety valves, instrumentation, branches.
Los procedimientos de impugnación de altas médicas en procesos de incapacidad temporal
Authors: Lozano Lares Francisco
Published: December 2023

El alta médica determina la extinción de la situación de incapacidad temporal, lo que lleva aparejado unos significativos efectos laborales y de seguridad social, puesto que implica la finalización del derecho a prestación económica por incapacidad temporal y la necesaria incorporación de la persona trabajadora a su puesto de trabajo. El parte de alta médica puede ser expedida desde diversas instancias, como el médico del servicio público de salud, el servicio médico de las mutuas colaboradoras con la seguridad social o la inspección médica del Instituto Nacional de Seguridad Social, por lo que se han implementado varios procedimientos de impugnación de altas médicas que es necesario conocer en profundidad para que las personas trabajadores no queden indefensas ante las altas médicas injustificadas que podrían afectar a su derecho fundamental a la salud y a su proceso de recuperación personal y profesional.
La mediación y el arbitraje laboral en el Procedimiento concursal: regulación y dificultades aplicativas.
Authors: Dormido Abril Julia
Published: December 2023

La declaración de concurso de una empresa no solo va a afectar al deudor concursado, pues tal calificación también tiene un efecto directo sobre los trabajadores. Sobre todo, si en el seno de un procedimiento concursal, para salvar la continuidad de la actividad empresarial, se decide adoptar alguna medida de reestructuración, tal y como pueden ser las modificaciones sustanciales de las condiciones de trabajo, el traslado, el despido, la suspensión de contratos o la reducción de jornada por causas económicas, técnicas, organizativas o de producción. Las decisiones que sobre cualquier de éstas se tomen pueden dar lugar a conflictos que tienen que solucionarse mientras el proceso judicial sigue su curso. Por ello, el legislador ha incorporado la mediación y el arbitraje en la norma mercantil como vías de solución extrajudicial de tales conflictos. Se trata de una fórmula jurídica no exenta de interrogantes, relacionados en este caso con aspectos como, la norma aplicable a tales mecanismos de solución extrajudicial, la incorporación de la solución al auto o el modo en el que impugnar el acuerdo o el laudo en materia laboral.
Potrzebne państwu polskiemu: Nauczycielki w systemie publicznych szkół powszechnych Drugiej Rzeczypospolitej (1918-1939)
Authors: Piotrowska-Marchewa Monika
Published: December 2023

uma opisanych w książce zagadnień, składających się łącznie na fenomen kobiecych doświadczeń zawodowych na polu oświaty powszechnej, przekracza – wskutek istnienia odrębnej od męskiej historii kobiet – tradycyjne cezury chronologiczne nie tylko historii politycznej, ale także klasycznie rozumianej historii oświaty, a nawet historii instytucji szkoły powszechnej jako takiej. [… ] Uwzględniać za to trzeba cezury dotyczące dziejów emancypacji i feminizmu, żeńskiego modelu socjalizacji, ewolucji praw kobiet, rozwoju ustawodawstwa cywilnego i wreszcie „prawodawstwa celibatowego”, którego emblematycznym przykładem w Polsce międzywojennej pozostaje obowiązująca lokalnie ustawa Sejmu Śląskiego z 1926 roku. [… ] Pomocnym zabiegiem okazało się prześledzenie procesu wchodzenia kobiet do zawodu nauczycielskiego, począwszy od XIX wieku, analiza ich ówczesnej sytuacji na tle realiów oświatowych trzech państw zaborczych, a także zarysowanie kobiecych przekonań na temat samego zawodu, swojej własnej w nim roli. [… ] Pozostają one komplementarne wobec zasadniczego zakresu chronologicznego prezentowanej książki, dla którego podstawową i wiążącą cezurę stanowią lata 1918-1939. Najważniejszą przesłanką pozostaje fakt budowy przez Drugą Rzeczpospolitą po dekadach zaborów własnego systemu polskiej oświaty. fragment Wprowadzenia
CONVERSAÇÕES EM AULA: UMA ANÁLISE DAS DINÂMICAS CONVERSACIONAIS DE AULAS REMOTAS
Authors: Pimentel Mariano , Carvalho Felipe
Published: December 2023

Neste artigo, por meio de uma abordagem teórico-metodológica baseada na Análise da Conversação, analisamos quantitativamente as conversas realizadas por videoconferência em um curso remoto de formação continuada ofertado em 2022 em uma universidade federal. O corpus de análise desta pesquisa consistiu nos vídeos-registros dos 15 encontros remotos realizados em três turmas, totalizando 45 vídeos, cada um contendo aproximadamente o registro de duas horas de conversa. Analisamos alguns desses registros para compreender as dinâmicas de conversação empregadas em aulas remotas. Medimos o tempo de fala de cada participante, comparamos o tempo de fala do professor em relação ao tempo de fala das/os estudantes, e caracterizamos como os turnos ocorreram ao longo de sessões de aula remota. Analisamos a conversação em função de dois aspectos: se o professor falou muito mais que as/os cursistas, e se todas/os as/os cursistas participaram da conversa. Identificamos empiricamente, através de uma abordagem indutiva, a realização de quatro dinâmicas de conversação: conversação focada no/a professor/a, conversação livre, conversação em fila e conversação em grupo. Argumentamos, a partir das análises apresentadas, que a promoção ou inibição da conversação nas aulas é um projeto, pois depende principalmente da dinâmica conversacional empregada na situação didática proposta pelo/a professor/a.
EDUCAÇÃO DA ATENÇÃO E CAMINHAR UBÍQUO NAS FORMAÇÕES NA/DA/COM (A) CIBERCULTURA NOS COTIDIANOS
Authors: Dos Reis Leonardo Rangel
Published: December 2023

No presente ensaio, pretendemos enlaçar a educação da atenção com a educação online, com o fito de apontar que nunca podemos prescindir dos nossos corpos, sobretudo porque eles consistem em nossa ligação sensível e nossa pertença primeira e primária com o mundo. Problematizando essas questões, o texto de cunho teórico-experiencial, já que se trata de teoria encarnada tecida nos movimentos cotidianos, busca articular a relação mediada com os computadores conectados com alguns movimentos da educação da atenção, explicitando a importância das ambiências na nossa relação primeira com o mundo. Esperamos que tenhamos conseguido apontar que as potências dos diversos usos cotidianos das coisas não se deixam inscrever em nenhum dilema dicotômico, ao invés, nos lançam no mundo, nos encontros em contatos mediados e diretos com outros seres e coisas.
REFLEXÕES SOBRE SOCIABILIDADES MEDIADAS PELO DIGITAL EM REDE (RE)CONFIGURANDO NOSSAS RELAÇÕES
Authors: Velloso Luciana , De Santana Leila Santos , Santos Lucia Helena de Andrade , De São Thiago Ana Clara Frey
Published: December 2023

No presente artigo pretendemos abordar algumas questões que têm mobilizado as discussões realizadas no âmbito do Grupo de Pesquisa “XXX”1. Para tanto, trazemos autores como Bauman (2011), Simmel (1973) e Velho (2001) para pensarmos em como estamos mudando as relações, interagindo uns com os outros. Urry (2007, 2010) nos auxilia a pensar como os avanços tecnológicos têm imbricado novas maneiras de constituir e organizar identidades. Nesse sentido, apresentamos as vivências dos cotidianos das pesquisadoras no momento da pandemia SARS Cov-2, bem como alguns frutos das pesquisas realizadasnesse contexto mais amplo, por considerarmos que são emblemáticas de um contexto social mais amplo que necessitam de registros e trocas. Reforçamos aqui a importância de nos apropriar das experiências de educação e formação mediadas por dispositivos digitais em rede e para tanto trazemos autores como Santos E. (2019), Santaella (2013) e Macedo (2000, 2012, 2021). Focamos, ainda, no que se refere ao necessário investimento e outros pontos a se discutir, no que tange às sociabilidades e os processos formacionais no pós pandemia.1 O nome do grupo de pesquisa foi omitido para garantir a avaliação as cegas.
CIBERFREIREANA: ATRAVESSAMENTOS TECNOLÓGICOS NA EDUCAÇÃO
Authors: Berino Aristóteles de Paula , Cosme Priscilla Brito , Sandim Roberta
Published: December 2023

O artigo propõe pensar a acerca da comunicação e educação a partir dos estudos da cibercultura na perspectiva das obras freireanas. A intenção é atualizar os aportes teóricos-metodológicos para pensar a escola em espaços outros, inclinados para a construção da criticidade, do conhecimento transformador. Atravessado pelo audiovisual no contexto da conectividade no fomento e uso pedagógico, além da formação de professores. Como método, tomamos embasamento teórico e bibliográfico acerca da interface do audiovisual focada no diálogo através da comunicação popular. Assim, propomos retomar as obras de Paulo Freire e a contribuição do seu legado para diálogos possíveis, por meio das tecnologias digitais na contemporaneidade.
PROCESSOS FORMATIVOS E OS FAZERESSABERES DOCENTES: CAMINHOS ‘PENSADOSPOSSÍVEIS’ COM OS CURRÍCULOS NOS COTIDIANOS
Authors: Garcia Alexandra , Rejuany Nora Klein da Silva
Published: December 2023

O presente artigo busca trazer reflexões sobre os caminhos ‘pensadospossíveis’ para criar “Educações” no atual contexto em que o período que vivenciamos da pandemia da Covid-19 deixou marcas em todo o cenário educacional, marcas essas que também mobilizaram criações diante das contingências, pois, esse período também nos mostrou algumas potencialidades nos processos de ensino, aprendizagem e de formação. Partindo dessa premissa, nosso objetivo com esse texto é abordar alguns aspectos para pensar as relações entre os saberes que ao longo de nossas trajetórias vão sendo tecidos e que compõem as redes com as quais produzimos os currículos e as existências das escolas a cada dia. Partindo do campo das pesquisas com os cotidianos e do trabalho com narrativas docentes vamos provocar ponderações sobre como a incompletude do saber pode nos impulsionar a tecer novos saberes, perceber a potência das narrativas docentes e tecer algumas considerações a respeito dos processos que nos formam e o modo como nesses processos vamos tecendo as nossas redes de conhecimento. Dialogaremos entre outros, com contribuições de Certeau (2013) a respeito das táticas dos praticantes, Moreira (2015) no que se refere às narrativas docentes no processo de formação e Santos (2019, 2020) com conceitos relativos à justiça social, justiça cognitiva, ao saber e ao corazonar.  O artigo buscou refletir quanto aos saberes docentes em diálogo com  as narrativas em processos de pesquisa e formação para tecer redes de conhecimento e processos formativos de formas mais coletivas e partilhadas na docência e entre escolas-universidade. PALAVRAS-CHAVE: Processos formativos. Narrativas. Redes de saberes.
Segurança do paciente sob a ótica de enfermeiros da estratégia saúde da família
Authors: Mucelini Fernanda Cristina , Silva Lara Adrianne Garcia Paiano da , Borges Fabieli , Guedes Giovanna Carolina , Goes Herbert Leopoldo de Freitas , Mucelini Isabella
Published: December 2023

Objetivo: identificar o conhecimento dos enfermeiros que atuam na Estratégia Saúde da Família quanto à segurança do paciente. Método: estudo qualitativo exploratório, descritivo, realizado com 20 enfermeiros da Estratégia Saúde da Família de um município paranaense. A coleta de dados foi realizada entre julho e dezembro de 2021 com entrevistas semiestruturadas. Os dados foram categorizados e analisados com auxílio do software Iramuteq. Resultados: os enfermeiros relataram dificuldades no processo de trabalho e aspectos que influenciavam nas ações relacionadas à segurança do paciente: falta de profissionais, sobrecarga de trabalho, falhas na comunicação, trabalho em equipe e processo de formação, impacto da pandemia contra COVID-19, eventos adversos e cultura de notificação. Considerações finais: o estudo demonstrou a fragilidade dos enfermeiros em relação à segurança do paciente na Atenção Primária à Saúde e a necessidade de o tema ser amplamente discutido entre todos os componentes das equipes da Estratégia Saúde da Família.
Percepções das mães que são profissionais de saúde sobre as relações na unidade neonatal
Authors: Villas Boas Allison Scholler de Castro , Corasini Isabela , Bonelli Maria Aparecida , Oliveira Ana Izaura Basso , Petruccelli Gabriele , Wernet Monika
Published: December 2023

Objetivo: discutir as percepções das mães que são profissionais de saúde sobre as relações na unidade neonatal. Método: estudo qualitativo, apoiado no Interacionismo Simbólico, com 11 mães de recém-nascidos pré-termo que são profissionais da saúde. Após aprovação pelo Comitê de Ética em Pesquisa, os dados foram coletados de maio a outubro de 2021, por meio de entrevistas individuais, e submetidos à análise de conteúdo temática. Resultados: apesar de as mães serem profissionais da saúde, as relações na unidade neonatal foram difíceis, sofridas, desconfortantes e restritivas ao processo de 'ser e tornar-se mãe'. Estas desvelaram sentimentos de não pertencimento ao cuidado e de afastamento de suas crianças. Conclusão: as relações entre mães e profissionais da saúde atuantes na unidade neonatal estiveram marcadas por sofrimentos, limitações e desconfortos, sendo lacunares em processos colaborativos, na contramão do Cuidado Centrado na Família.
O contexto vivido pelo familiar e pessoa em tratamento hemodialítico
Authors: Borges Bárbara Ebilizarda Coutinho , Oliveira Nathália Luiza Cândido de , Medeiros Marília Rute de Souto , Silva Jose Lenartte da , Silva Maria Leonor Paiva da , Vitor Allyne Fortes , Távora Rafaela Carolini de Oliveira
Published: December 2023

Objetivo: compreender o contexto vivido pelo familiar e pessoa em tratamento hemodialítico. Método: estudo descritivo exploratório, qualitativo e transversal, aprovado pelo comitê de ética em pesquisa, realizado com pacientes com doença renal crônica e seus familiares, em um munícipio do interior do estado do Rio Grande do Norte, entre junho e julho de 2019. Utilizada entrevista semiestruturada, com perguntas norteadoras para a composição estrutural do genograma e ecomapa. Posteriormente à transcrição das falas, seguiu-se a leitura e construção das categorias a partir das informações encontradas. Resultados: Foram realizadas 18 entrevistas, compondo nove famílias participantes, obtendo-se as categorias: Apoio da família, Apoio externo à família, Renúncia e Enfrentamento da doença. Conclusão: a maneira com que cada paciente e família irão vivenciar o estar doente e interpretar esse significado fará essa adaptação particular e pessoal, assim como o seu enfrentamento, particularmente ao considerar que, no núcleo familiar, ocorre uma reestruturação em meio às demandas de cuidado.
Plantas medicinais entre Agentes Comunitários de Saúde Ribeirinhos: conhecimento, uso, forma de preparação e indicação
Authors: Silva Mariana Paula da , Marcelino Rodrigo Silva , Guimarães Ananias Facundes , Silva Sulyane Ferreira da , Reis Marcelo Henrique da Silva , Portugal Jéssica Karoline Alves , Lima Paula Andreza Viana , Gama Abel Santiago Muri
Published: December 2023

Objetivo: descrever conhecimento, uso, forma de preparação, indicação para problemas de saúde de plantas medicinais entre Agentes Comunitários de Saúde ribeirinhos. Método: estudo descritivo, transversal, entre 117 Agentes Comunitários de Saúde Ribeirinhos, realizado entre agosto a novembro de 2018, sobre os hábitos de consumo de plantas medicinais, uso associado a medicamentos industrializados, aprendizado, parte utilizada, forma de preparação, indicação e problemas de saúde. O estudo foi aprovado pelo Comitê de Ética em Pesquisa. Resultados: as plantas medicinais mais utilizadas foram o Capim Santo (Cymbopogon citratus) (11,1%), Erva Cidreira (Melissa officinalis) (9,3%) e o Boldo (Vernonia condensata) (6,5%). Houve associação significativa entre consumo de plantas e faixa etária, escolaridade, problemas de saúde e plantas no quintal. Conclusão: o desenvolvimento de estratégias de promoção do conhecimento sobre plantas medicinais e seu uso adequado entre os ACS ribeirinhos, pode promover o autocuidado com a saúde nas áreas remotas da Amazônia brasileira.
Severe traumatic brain injury in adults: a review of critical care management
Authors: McLernon Siobhan
Published: December 2023

This second of a two-part review on traumatic brain injury (TBI) describes management for adult patients with a severe TBI (post-resuscitation Glasgow Coma Scale score ≤ 8) who require critical care based on evidence and recommendations. Evidence-based, standardised practice aims to limit secondary injury in patients with TBI. Critical care management is based on maintaining optimal physiology to minimise secondary injury in the early acute phase. The aim is to save lives and improve the quality of outcome for survivors.