bluuebunny/crossref_metadata_2025 huggingface dataset:
СHESS DEVELOPMENT MANAGEMENT
Authors: Shmygol N.M.  , Yelisieiev Ye.Yu .
Published: June 2023

Objective. The objective of the present article is to study the definition of chess as a special kind of sport, research on the development of chess sport in Ukraine and the world, analysis of the management organization of chess sport in Ukraine, evaluation of the management quality of the Dnipropetrovsk Regional Chess Federation for the development of chess sport.

Methods. In the course of the research a set of scientific methods was used: methods of scientific generalization, comparison, method of expert evaluations; graphic and tabular techniques. used information and analytical products.

Results. Theoretical aspects of the essence of the concept of sports management, the specifics of chess as a sport, it is argued that chess is a specific type, which is carried out in the form of intellectual martial arts and belongs to the fifth group of sports: abstract games. The system of chess training should consist of physical, technical, tactical, psychological, informational, and intellectual training. The development of chess is closely linked to the development of IT technologies, which makes learning chess more convenient and more effective. A personal computer with installed chess information retrieval systems, programs, electronic databases and Internet resources has the functions of an artificial assistant coach. After studying the essence of the concept of sports management, it was found that it is both a field of human knowledge, and the field of management decision-making, and the category of people united in an economically competitive system for managing a sports organization. Sports management in the context of globalization is aimed at team sports work, requires athletes to coordinate actions and cooperation and is implemented depending on the differential problems of sport.
EUROPEAN EXPERIENCE OF TOURIST SERVICES MARKET DEVELOPMENT IN THE POST-PANDEMIC PERIOD: TRADITIONS AND INNOVATIONS
Authors: Barabanova V. V. , Bohatyryova G. A.
Published: June 2023

Objective. The objective of the present article is to study the possibilities of implementing European experience in the tourist services market development in the post-pandemic period to increase the potential of the tourism industry of Ukraine.

Methods. The theoretical and methodological basis of the study is the position of modern economic theory, management theory, scientific works of domestic and foreign scientists in the field of tourism market development. The methods of comparison, abstraction, analysis and generalization, as well as tabular and graphic modeling, the method of modeling complex systems were used in the research

Results. Authors have studied the main challenges of the development of the tourist services market for the EU countries, determined the peculiarities of the functioning of the European tourist services market, studied the experience of its development in European countries as an important component of the state tourism policy; analysed growth rates of international tourist arrivals in the pandemic and post-pandemic period of 2019-2020. Much attention is paid to the search for strategic alternatives for the development of the tourism industry in EU countries in the post-pandemic period and the peculiarities of their implementation in the national tourism industry through changes in tourism products and consumer needs.

The factors of the tourist services market development in the EU countries are identified, the development and creation of the latest types of tourism, digital transformation of the tourism sector, active use of augmented and virtual reality applications in the tourist services market, activation of online presence, etc. are included. Conclusions were made regarding the importance of implementing the European experience in the development of the tourist services market to increase the potential of the tourism industry of Ukraine.
FORMATION OF THE WORLD INDUSTRIAL TOURISM SERVICES MARKET MECHANISM STRUCTURE AND FUNCTIONING
Authors: Koshel V. O.
Published: June 2023

Objective. The objective of the research is to form the structure and functioning mechanism of the world industrial tourism services market.

Methods. To achieve this goal, a set of general scientific and special methods of analysis is used, namely: theoretical generalization, analysis and synthesis (to investigate the essence of the industrial tourism services market and its components); abstract-logical (to determine approaches to the formation of the industrial tourism services market structure), system-structural and grouping, modeling (to compile the structure and mechanism of the world industrial tourism services market).
CURRENT TRENDS AND PROSPECTS OF RETAIL DEVELOPMENT iN UKRAINE
Authors: Nikolaichuk О.А. , Kostakova Lina
Published: June 2023

Objective. The objective of the study is to analyze the main trends in the development of domestic retail trade and identify prospects for its further development.

Methods. The research methods are the dialectical method of scientific cognition, general scientific methods: analysis, synthesis, systematization, comparison, grouping, method of relative quantities, abstract-logical method (for formulating conclusions).

Results. The indicators of retail trade of Ukraine during 2017–2020 are analyzed. The growth of the physical volume of retail trade turnover and the predominance in its structure of trade in non-food products are established. Significant differentiation of regional development by retail trade turnover is revealed. It is highlighted that higher positions in the regional structure are traditionally occupied by regions with higher indicators of socio-economic development and regions with a tourist orientation. Analysis of the dynamics of development of domestic retail chain points on the transformation processes in 208-2019, manifested in the reduction of the number and area of ​​hypermarkets, increasing the role of stores format "near the house". Estimation of financial results of retail trade enterprises in 2017-2020 indicates their instability. As a result of the COVID pandemic, the trends of digitalization of retail trade have intensified, consumer behaviour has changed, which has led to the choice of home stores, increased online shopping, shopping with mobile devices, development of delivery services and self-pickup points, rapid development of marketplaces, active use of IT solutions level and quality of trade services, greening, increased attention to health and well-being. For the effective functioning of domestic retail trade it is necessary to introduce innovations, use updated tools of interaction with the consumer, integration and automation.
EFFICIENCY OF ENTERPRISE MANAGEMENT: CONCEPTUAL APPROACHES TO DEFINITION AND MEASUREMENT
Authors: Pryimak N. S. , Кулієв К.С. , Baditsa А. V.
Published: June 2023

Objective. The objective of the article is to form a concept for determining the effectiveness of enterprise management in a competitive environment in accordance with the strategic goals of enterprise management.

Methodology. In the process of research, a set of general scientific methods and research techniques is used: analysis, synthesis, generalization, induction, deduction, the method of analogies. The theoretical and methodological base of the study the provisions of the theory of strategic management, strategic analysis, economic diagnostics, as well as the theory of systems efficiency. To systematize and generalize the numerical material in the study, the methods of tabular and graphical analysis are applied.

Results. In the article, based on the study of the main approaches of scientists to the interpretation of the category "efficiency of enterprise management", it is determined that it should be understood as the effectiveness of the functioning of the current management system, determined by comparing the volumes of resources (costs) consumed in the process of achieving goals with the results obtained. Based on the development of the concept of a two-level environment of enterprise activity, it is proposed to determine the efficiency of enterprise management in terms of external efficiency (as the basis of business competitiveness in market conditions) and internal efficiency (determined on the basis of a cumulative analysis of the economic efficiency of management, financial efficiency and efficiency of potential management based on the resource approach formation). The approbation of the proposed approach to assessing the effectiveness of management is carried out on the materials of PJSC "TsGOK" and proved its viability. The developed concept for determining the effectiveness of management involves the implementation of a number of diagnostic stages: setting research goals, defining its key objectives; assessment of the results of the enterprise in the main key areas: production, use of fixed assets, current assets, personnel, materials, etc .; assessment of the external environment, competitive conditions of activity and the strategic position of the enterprise in the market; analysis of indicators by groups: assets; efficient resource management; monetary results of activities; liquidity and financial strength; generalization of the results of the analysis of management efficiency, identification of the strengths and weaknesses of the management process; identification of existing reserves; development of measures to improve the efficiency of enterprise management and build up competitive advantages.
SERVICES OF LOCAL PRODUCERS AS A PARAMETER OF QUALITY OF LIFE OF THE POPULATION OF KRYVYI RIH
Authors: Hladkova I. O.
Published: June 2023

Objective. The objective of the article is to study the problem of providing services to the population in the regional dimension.

Methods. The theoretical basis of the study are the achievements of foreign and domestic scientists in management decisions and their justification. To achieve this goal, the following research methods are used: analysis of statistical data, analysis of marketing research "The state of the service market in Kryvyi Rih."

Results. The presented article brings about the issue of the quality of human life in the modern world on the basis of such an important parameter as the provision of various social services. This survey is devoted to the study of social services provided to residents of the city of Kryvyi Rih, Dnipropetrovsk region during 2020. Analyzing previous publications on the topic, the author testifies to the fact that there is a wide range of services in the field of public administration and the emphasis on social services in the context of social protection and decentralization of power. The purpose of the presented study is to study the problem of providing services to the population in the regional dimension.

The reconnaissance is written on the materials prepared, processed and stored in the archives of the municipal enterprise "Institute of Development of the City of Kryvyi Rih". This article has scientific novelty, because it contains previously unused content, in particular, the final results of representative sociological surveys according to the method of questionnaires, which were conducted among the residents of Kryvyi Rih. The subject of the author's research are the services most in demand by ordinary citizens, such as: hairdressing, individual tailoring or repair of clothing and footwear, catering, leisure, care for the elderly and more. The central aspect of the study is the problem of availability and quality of medical services, which is especially relevant in a pandemic.
MARKETING ASPECTS OF GOODS COMPETITIVE ADVANTAGES FORMATION ON THE MARKET OF UKRAINE
Authors: Barabanova V. V. , Bohatyryova H. A. , Popova Y. S.
Published: June 2023

Objective. The objective of the article is to substantiate the innovative marketing approach to the formation of competitive advantages of goods on the market of Ukraine, its focus on customer needs, to improve management through the use of innovative marketing instruments that will ensure the competitiveness of goods on the market of Ukraine.

Methods. The theoretical and methodological basis of the study is the set of modern economic theory, management theory, scientific works of domestic and foreign scientists in the field of marketing. The following methods are used to ensure logical essence in the study - the dialectical method of scientific knowledge, the method of system-structural analysis, the method of modeling complex systems.

Results. In the article the authors consider the features of innovative marketing approach to the formation of competitive advantages of goods in the market, the ability to offer and sell competitive goods with the acquisition of additional services for better customer service. The importance of individual marketing for the sale of goods and services for each individual consumer based on constant contact with customers, marketing awareness of the product is justified.

The essence of the marketing approach to the formation of competitive advantages on the example of the market of cosmetic products with the use of innovative approach to marketing decisions, brand loyalty, creative advertising etc. is researched.

The authors develop a structural and functional model of the formation of competitive advantages of goods on the basis of innovative marketing approach as consumer-oriented marketing, the development of new types of goods that consumers need and want to get.

Innovative marketing instruments that will promote the formation of competitive advantages of goods on the market of Ukraine are proposed
Управління розвитком економічного середовища в умовах глобальних трансформацій: колективна монографія
Authors:   Українська інженерно-педагогічна академія, Прохорова В. В.
Published: June 2023

В колективній монографії розглядаються питання трансформації сучасної економіки в умовах макроекономічної стабілізації, сучасного управлінського інструментарію розвитку в умовах інноваційної економіки, інтелектуалізації управління стійким розвитком в умовах соціально-орієнтованої економіки, стратегії формування сучасних напрямів розвитку економічних систем, інноваційні практики цифровізації бізнес середовища. Колективна монографія розрахована на фахівців, науковців, викладачів, аспірантів і здобувачів економічних спеціальностей. Опубліковані матеріали відображають власну думку авторів, яка може не збігатися з позицією редакції та носити дискусійний характер. За зміст матеріалів відповідальність несуть автори.
NARASI OBJEKTIVASI PEREMPUAN DALAM NOVEL PEREMPUAN BATIH KARYA A.R. RIZAL
Authors: Bahiyah Kholidatul
Published: June 2023

Women with various problems are very interesting to be discussed in studying a topic of discussion, because women are often marginalized. This becomes the cause and effect of the occurrence of various forms of a woman's struggle to maintain her existence and attracts it to become a topic of discussion. There are three scopes of aspects that are the focus of research related to the objectivation narrative of women in the novel Batih Women by A.R. Rizal, namely: (1) The objectivation narrative of women's existence in the novel Perempuan Batih by A.R. Rizal, (2) The objectivation narrative of women's position in the novel Perempuan Batih by A.R. Rizal, and (3) The objectivation narrative of the role of women in the novel Perempuan Batih by A.R. Rizal. This study aims to describe the objectivation narrative of women's existence in the novel Perempuan Batih by A.R. Rizal, describes the objectivation narrative of women's position in the novel Perempuan Batih by A.R. Rizal, and describes the objectivation narrative of the role of women in the novel Perempuan Batih by A.R. Rizal. Based on the results of the research, it shows that the objectivation narratives of women are divided into, 1) the objectivation narratives of women's existence which consist of views on the differences in women's positions, women's violence in terms of service in marriage, and women as men's subordinates. 2) narrative objectivation of women's position which consists of position as an individual, position in the family sphere, and position in the community sphere. 3) objectivation narratives of women's roles consisting of women's roles from a biological or environmental tradition and women's roles from their position as individuals and not as husband's assistants.
Metode AHP dalam Sistem Pendukung Keputusan pada Pemilihan Website Penerbangan Online
Authors: Maysaroh Maysaroh , Fahmi Muhammad , Destiana Henny , Maulana Yana Iqbal , Komarudin Ishak
Published: June 2023

Jasa transportasi saat ini banyak dibutuhkan baik itu transportasi darat, laut ataupun udara. Didukung dengan Information Technology menambah persaingan antar perusahaan jasa penjualan tiket online dalam melakukan promosi penjualannya. Bisnis jasa transportasi dituntut untuk mampu memberikan pelayanan, penawaran, dan promosi sebaik mungkin agar dapat bersaing dengan biro jasa transportasi online lain dalam menarik konsumen. Persaingan antar perusahaan online atau travel agent sangat kompetetif, dengan adanya persaingan maka dibuatlah penelitan untuk menguji website website penerbangan online mana yang paling diminati oleh konsumen saat ini, 4 website penerbangan online yang diambil untuk penelitian ini yaitu Tiket.com, Traveloka, Pegi-pegi.com dan Nusatrip. Dengan menggunakan metode Analytical Hierarchy Process atau yang lebih dikenal dengan AHP. Metode AHP dipilih karena dapat menyeleksi alternatif terbaik dari sejumlah alternatif pilihan berdasarkan kriteria yang telah ditentukan. sehingga nantinya penelitian ini memudahkan konsumen untuk memutuskan dalam memilih website website penerbangan online yang terbaik atau yang paling banyak diminati. Selain itu Metode AHP merupakan salah  satu metode yang paling relevan dan memiliki perhitungan nilai konsistensi dalam menentukan tingkat prioritas kriteria pemilihan. Dari hasil  pengujian maka didapatkan hasil bahwa website Traveloka merupakan yang sangat tinggi nilainya dengan nilai Traveloka (0,49), Tiket.com (0,22),  Pegipegi.com (0,19), dan Nusatrip (0,11).
Pelaksanaan Administrasi Penjualan Barang Pada PT Sinar Bangkit Jayalabel
Authors: Lestari Nurlaela Eva Puji , Agustina Teni , Zahro Nurus , Andriani Ria
Published: June 2023

Pelaksanaan Administrasi Penjualan Barang pada PT Sinar Bangkit Jayalabel, merupakan kegiatan yang berkaitan dengan kegiatan catat, mencatat, menghimpun, mengelola, mengirim, dan menyimpan. Administrasi adalah suatu bagian yang terpenting dalam mengelola suatu usaha atau bisnis. Selain itu fungsi administrasi juga memberikan laporan kepada pemangku kepentingan data khususnya laporan strategi bagi manajemen untuk memantau perkembangan perusahaan untuk mengambil keputusan. PT Sinar Bangkit Jayalabel merupakan perusahaan yang bergerak di Aksesoris Garment. PT Sinar Bangkit Jayalabel sebagian besar melakukan kegiatan penjualan produk, sehingga dalam pelaksanannya diperlukan kegiatan adminstrasi penjualan untuk menunjang kegiatan penjualannya. Metode penelitian ini menggunakan metode analisis Kualitatif. Hasil pada penelitian ini dapat disimpulkan bahwa proses alur pelaksanaan administrasi penjualan pada PT Sinar Bangkit Jayalabel dimulai dari customer service menerima orderan sampai dengan finance menerima laporan barang yang sudah dibayar. Dokumen yang dibutuhkan yaitu surat jalan, Surat Purchase Order, dan Invoice.
Strategi Dalam Peningkatan Olahan Pastry Dan Bakery Di Hotel Best Western Premier The Hive Cawang Jakarta Timur
Authors: Purwanto Eko Obi , Anggraeni Jesica Yopi , Candrasari Ati , Puspita Ratna , Putra Nova Yudha Andriansyah
Published: June 2023

Food and Beverage produk merupakan salah satu departmen di hotel yang mengatur semua makanan dengan skala yang cukup besar, yang mempunyai tanggung jawab khusus karena sebuah departemen yang ada di bawah naungan suatu hotel dalam penghidangan atau pengelolahan makanan serta minuman yang memiliki tanggung jawab mengelolah bahan makanan yang dikreasikan sehingga menciptakan berbagai jenis olahan makanan dengan rasa yang bisa di nikmati. Dari latar belakang diatas maka peneliti  tertarik untuk mengambil judul “ Strategi dalam Peningkatan olahan Pastry dan Bakery di Hotel Best Western Premier The Hive Cawang, Jakarta Timur”.
Rancang bangun sistem pengaman rumah dengan aplikasi android berbasis motion detection dan QR code
Authors: Wirayoga Septriandi , Imammuddien Azam Muzakhim , Wahyuningsih Fama Dwi , Harismawati Secondamega
Published: June 2023

Pada rumah yang terdapat di perkotaan sering kali terjadi pencurian barang atau kendaraan. Pada saat bepergian pemilik rumah akan merasa tidak aman jika meninggalkan rumah tanpa pengawasan. Alat yang dibuat pada penelitian ini bertujuan untuk membuat pengamanan rumah pada saat pemililik rumah sedang bepergian dan membuat alat untuk mengurangi tingkat pencurian terutama di daerah perkotaan. Pada prototype sistem keamanan rumah ini membutuhkan aplikasi android yang dirancang pada kodular, kodular merupakan layanan berbasis web yang digunakan dalam hal pemograman untuk merancang dan membuat suatu aplikasi android kemudian membutuhkan firebase untuk menyimpan data. Sensor PIR (Passive Infra Red) HC-SR501 yang digunakan pada alat ini dapat mendeteksi pergerakan seseorang dengan jarak maksimal 400 cm. Sensor proximity E18-D80NK yang digunakan pada alat ini dapat mendeteksi pergerakan objek dengan jarak maksimal 60 cm.

 

ABSTRACTIn houses located in urban areas, theft of goods or vehicles is often the case. When traveling, homeowners will feel unsafe if they leave the house unattended. The tool made in this study aims to make home security when the homeowner is traveling and make tools to reduce the theft rate, especially in urban areas. The prototype of this home security system requires an android application designed on modular, modular is a web-based service that is used in programming to design and create an android application then requires firebase to store data. The HC-SR501 PIR (Passive Infra Red) sensor used in this tool can detect the movement of a person with a maximum distance of 400 cm. The E18-D80NK proximity sensor used in this tool can detect the movement of objects with a maximum distance of 60 cm.
Propuesta de nuevo modelo de caracterización de adopción de TIC en pymes argentinas:
Authors: Tricoci Guillermo-Alberto , Oriolo María-Cecilia , Stefanoff Germán
Published: June 2023

El objetivo del presente trabajo consiste en la generación de un modelo conceptual para el análisis y evaluación del proceso de adopción de TIC en el ámbito de las pymes argentinas considerando cuatro entornos y factores asociados a los mismos. Este modelo conceptual será aplicado a un futuro trabajo de campo, para la realización de un proceso de calibración y propuesta de una nueva versión del modelo presentado. La mayor diferencia de los modelos previos tiene que ver con una visión actualizada de los modelos de negocios y mercados, producto fundamentalmente de la evolución de la conectividad.
Suicide Phenomenon Among Students During the COVID-19 Pandemic
Authors: Siburian Donny Paskah Martianus
Published: June 2023

Abstract
This article discusses the impact of the COVID-19 pandemic on human life, particularly in the field of education. In an effort to address the pandemic, the government has implemented Distance Learning Education (PJJ) as a relevant solution, but it has resulted in unintended consequences, including increased stress and suicide among students. This research uses a qualitative method with a case study and sociological analysis using Emile Durkheim's theory of suicide. The analysis results show that suicidal behavior among students occurs due to social symptoms, especially in facing rapid changes and social isolation caused by the COVID-19 pandemic. Students face greater pressure to adapt to these changes, both in their education and social environment. Therefore, appropriate and comprehensive prevention and intervention efforts need to be taken to address this problem and prevent suicide among students.
Keywords: Suicide; Online Learning; Stress; Emile Durkheim
A convolutional neural network to characterize mouse hindlimb foot strikes during voluntary wheel running
Authors: Huber Phillipe , Ausk Brandon J. , Tukei K. Lionel , Bain Steven D. , Gross Ted S. , Srinivasan Sundar
Published: June 2023

Voluntary wheel running (VWR) is widely used to study how exercise impacts a variety of physiologies and pathologies in rodents. The primary activity readout of VWR is aggregated wheel turns over a given time interval (most often, days). Given the typical running frequency of mice (∼4 Hz) and the intermittency of voluntary running, aggregate wheel turn counts, therefore, provide minimal insight into the heterogeneity of voluntary activity. To overcome this limitation, we developed a six-layer convolutional neural network (CNN) to determine the hindlimb foot strike frequency of mice exposed to VWR. Aged female C57BL/6 mice (22 months, n = 6) were first exposed to wireless angled running wheels for 2 h/d, 5 days/wk for 3 weeks with all VWR activities recorded at 30 frames/s. To validate the CNN, we manually classified foot strikes within 4800 1-s videos (800 randomly chosen for each mouse) and converted those values to frequency. Upon iterative optimization of model architecture and training on a subset of classified videos (4400), the CNN model achieved an overall training set accuracy of 94%. Once trained, the CNN was validated on the remaining 400 videos (accuracy: 81%). We then applied transfer learning to the CNN to predict the foot strike frequency of young adult female C57BL6 mice (4 months, n = 6) whose activity and gait differed from old mice during VWR (accuracy: 68%). In summary, we have developed a novel quantitative tool that non-invasively characterizes VWR activity at a much greater resolution than was previously accessible. This enhanced resolution holds potential to overcome a primary barrier to relating intermittent and heterogeneous VWR activity to induced physiological responses.
Environmental distribution and seasonal dynamics of Marteilia refringens and Bonamia ostreae, two protozoan parasites of the European flat oyster, Ostrea edulis
Authors: Mérou Nicolas , Lecadet Cyrielle , Ubertini Martin , Pouvreau Stéphane , Arzul Isabelle
Published: June 2023

Introduction

Marteilia refringens and Bonamia ostreae are protozoan parasites responsible for mortalities of farmed and wild flat oysters Ostrea edulis in Europe since 1968 and 1979, respectively. Despite almost 40 years of research, the life-cycle of these parasites is still poorly known, especially regarding their environmental distribution.

Methods

We carried out an integrated field study to investigate the dynamics of M. refringens and B. ostreae in Rade of Brest, where both parasites are known to be present. We used real-time PCR to monitor seasonally over four years the presence of both parasites in flat oysters. In addition, we used previously developed eDNA based-approaches to detect parasites in planktonic and benthic compartments for the last two years of the survey.

Results

M. refringens was detected in flat oysters over the whole sampling period, sometimes with a prevalence exceeding 90%. It was also detected in all the sampled environmental compartments, suggesting their involvement in parasite transmission and overwintering. In contrast, B. ostreae prevalence in flat oysters was low and the parasite was almost never detected in planktonic and benthic compartments. Finally, the analysis of environmental data allowed describing the seasonal dynamics of both parasites in Rade of Brest: M. refringens was more detected in summer and fall than in winter and spring, contrary to B. ostreae which showed higher prevalence in winter and spring.

Discussion

The present study emphasizes the difference between M. refringens and B. ostreae ecology, the former presenting a wider environmental distribution than the latter, which seems closely associated to flat oysters. Our findings highlight the key role of planktonic and benthic compartments in M. refringens transmission and storage or potential overwintering, respectively. More generally, we provide here a method that could be useful not only to further investigate non cultivable pathogens life-cycle, but also to support the design of more integrated surveillance programs.
Cardamom agro-environmental interrelationships analysis in Indian cardamom hills
Authors: Murugan Muthusamy , Kuruvila Anil , Anandhi Aavudai , Pooja A. , Ashokkumar Kaliyaperumal , Dhanya M. K. , Subbiah A. , Alagupalamuthirsolai M. , Sritharan N.
Published: June 2023

The rainfall pattern seen in the Indian Cardamom Hills (ICH) has been extremely variable and complicated, with El Niño-Southern Oscillation (ENSO) playing a crucial role in shaping this pattern. In light of this, more investigation is required through improved statistical analysis. During the study period, there was greater variability in rainfall and the frequency of rainy days. About 2,730 mm of rainfall was reported in 2018, while the lowest amount (1168.3 mm) was registered for 2016. The largest decrease in decadal rainfall (>65 mm) was given by the decade 1960–1969, followed by 1980–1989 (>40 mm) and 2010–2019 (>10 mm). In the last 60 years of study, there has been a reduction of rainy days by 5 days in the last decade (2000–2009), but in the following decade (2010–2019), it registered an increasing trend, which is only slightly <2 days. The highest increase in decadal rainy days was observed for the 1970–1979 period. The smallest decadal increase was reported for the last decade (2010–2019). Total sunshine hours were the highest (1527.47) for the lowest rainfall year of 2016, while the lowest value (1,279) was recorded for the highest rainfall year (2021). The rainfall characteristics of ICH are highly influenced by the global ENSO phenomenon, both positively and negatively, depending on the global El Nino and La Nina conditions. Correspondingly, below and above-average rainfall was recorded consecutively for 1963–1973, 2003–2016, and 1970–2002. Higher bright forenoon sun hours occurred only during SWM months, which also reported maximum disease intensity on cardamom. The year 2016 was regarded as a poorly distributed year, with the lowest rainfall and the highest bright afternoon sun hours during the winter and summer months (January-May). Over the last three decades, the production and productivity of cardamom have shown a steady increase along with the ongoing local climatic change. Many of our statistical tests resulted in important information in support of temporal climatic change and variability. Maintaining shade levels is essential to address the adverse effects of increasing surface air temperature coupled with the downward trend of the number of rainy days and elevated soil temperature levels.
The first clinical data of the SAPIEN 3 aortic valve in the treatment of aortic stenosis in China
Authors: Shang Xiaoke , Pan Xiangbin , Zhang Gejun , Jiang Zhengming , Liu Xianbao , Song Guangyuan , Li Yi , Wang Yan , Luo Jianfang , Tang Yida , Yuan Yiqiang , Wu Yongjian , Ma Xiang , Zhu Dan , Zhong Yucheng , Zhang Changdong , Dong Nianguo
Published: June 2023

Background

Data on outcomes following transcatheter aortic valve replacement with SAPIEN 3 in China is limited as it was approved by the National Medical Products since 2020. The present study was designed to collect clinical data on the SAPIEN 3 aortic valve in Chinese patients with bicuspid aortic valve and tricuspid aortic valve stenosis.

Methods

We analyzed the patient characteristics, procedural features and procedural outcomes of the first 438 patients (223 for bicuspid aortic valve and 215 tricuspid aortic valve) from 21 provinces in 74 sites treated with the SAPIEN 3 valve system for transcatheter aortic valve replacement between September 2020 and May 2022.

Results

Procedural mortality was 0.7%. 5 cases during the operation were converted to surgery. Among 438 cases, permanent pacemaker implantation was performed in a total of 12 cases (2.7%). The patient had severe leaflet calcification of the aortic valve, with moderate and severe calcification reaching 39.7% and 35.2% respectively. The size of the implanted valves was predominantly 26 mm and 23 mm, reaching 42.5% and 39.5% respectively. The incidence of moderate or severe perivalvular leak in the postoperative period was 0.5%, with a predominance of 90/10 and 80/20 valve deployment height. There was a significant difference in the deployment height of the valve between bicuspid aortic valve and tricuspid aortic valve, with the bicuspid aortic valve having a more deployment height of 90/10. Annulus size in bicuspid aortic valve group was significantly larger than tricuspid aortic valve group. Valve sizing for oversized, within size, and undersized were different between bicuspid aortic valve and tricuspid aortic valve.

Conclusions

Procedural success rates were high, with similar and good results for bicuspid aortic valve and tricuspid aortic valve, low perivalvular leak for both valve types, and low permanent pacemaker implantation rates for both valve types. Annulus size, valve sizing and coronary artery height were significantly different in the BAV and TAV group.
Left atrial appendage occlusion in the absence of intraprocedural product specialist monitoring: is it time to proceed alone? Results from a multicenter real-world experience
Authors: Margonato Davide , Rizza Vincenzo , Ingallina Giacomo , Preda Alberto , Ancona Francesco , Belli Martina , Godino Cosmo , Agricola Eustachio , Della Bella Paolo , Grasso Carmelo , Contarini Marco , Mazzone Patrizio
Published: June 2023

Background

Percutaneous left atrial appendage occlusion (LAAO) presents many technical complex features, and it is often performed under the intraprocedural surveillance of a product specialist (PS). Our aim is to assess whether LAAO is equally safe and effective when performed in high-volume centers without PS support.

Methods

Intraprocedural results and long-term outcome were retrospectively assessed in 247 patients who underwent LAAO without intraprocedural PS monitoring between January 2013 and January 2022 at three different hospitals. This cohort was then matched to a population who underwent LAAO with PS surveillance. The primary end point was all-cause mortality at 1 year. The secondary end point was a composite of cardiovascular mortality plus nonfatal ischemic stroke occurrence at 1 year.

Results

Of the 247 study patients, procedural success was achieved in 243 patients (98.4%), with only 1 (0.4%) intraprocedural death. After matching, we did not identify any significant difference between the two groups in terms of procedural time (70 ± 19 min vs. 81 ± 30 min, p = 0.106), procedural success (98.4% vs. 96.7%, p = 0.242), and procedure-related ischemic stroke (0.8% vs. 1.2%, p = 0.653). Compared to the matched cohort, a significant higher dosage of contrast was used during procedures without specialist supervision (98 ± 19 vs. 43 ± 21, p < 0.001), but this was not associated with a higher postprocedural acute kidney injury occurrence (0.8% vs. 0.4%, p = 0.56). At 1 year, the primary and the secondary endpoints occurred in 21 (9%) and 11 (4%) of our cohort, respectively. Kaplan–Meier curves showed no significant difference in both primary (p = 0.85) and secondary (p = 0.74) endpoint occurrence according to intraprocedural PS monitoring.

Conclusions

Our results show that LAAO, despite the absence of intraprocedural PS monitoring, remains a long-term safe and effective procedure, when performed in high-volume centers.
Laboratory modeling of thermal and temporal cracking in swelling clays
Authors: Zhang Gang , Jaffar Syed Taseer Abbas , Israr Jahanzaib , Atta Muneeb , Jafri Turab
Published: June 2023

Crack development in a changing environment is the controlling factor for the stability and strength of expansive soils. Expansive soils exhibit large volumetric changes with changes in their moisture conditions that may occasionally lead to reduced bearing capacity and foundation failures. This study purports to model crack initiation and its spatial progression in relation to the moisture content and drying period, respectively. Volumetric soil shrinkage is determined using high-definition digital camera imaging and Vernier scale methods, while the soil settlement under vertical shrinkage deformation could be captured through a tensile stress model for soils. It was revealed that a small change in suction could trigger crack initiation, which would propagate further under different environmental conditions. Furthermore, it was observed that the crack volume increased rapidly at specific moisture content and could penetrate as deep as 1 m after nearly 1.5 months that is fully consistent with the current model predictions. A comparison between the performance of the model proposed in this study and that of two existing models shows that the former predicts the vertical shrinkage strain values in closer agreement with those observed experimentally and is less conservative than those predicted by both models. Nevertheless, the findings from this study could be used to quantify the detrimental behavior of expansive soil present in pavement subgrades and shallow foundations for lightweight structures.
Surviving the storm: manual vs. mechanical chest compressions onboard a lifeboat during bad weather conditions
Authors: Venema Allart M. , Sahinovic Marko M. , Absalom Anthony R. , Wietasch J. K. Götz
Published: June 2023

Objective

It is challenging for rescuers to perform cardiopulmonary resuscitation (CPR) onboard lifeboats, particularly during rough weather. A mechanical chest compression device (MCD) may provide better quality chest compressions. The aim of this study was to compare the quality of chest compressions performed by lifeboat-crewmembers with those of a MCD during rough-sea conditions.

Methods

Lifeboat-crewmembers were scheduled to provide compression-only CPR on a resuscitation-mannequin during two sets of five 6-min epochs on a lifeboat at sea in two different weather-conditions. Simultaneously a MCD was used for compression-only CPR on another mannequin onboard the lifeboat. On a third occasion compressions by MCD only were measured due to COVID-19 restrictions. The primary outcome variable was the quality of chest compression, evaluated using published variables and standards (mean compression depth and compression frequency, percentage correct compression depth, percentage of not leaning on the thorax, percentage of correct hand placement on the thorax, hands-off-time).

Results

Six male lifeboat-crewmembers (mean age 35 years) performed CPR during two different weather conditions. In weather-conditions one (wind ~6–7 Beaufort/wave-height: 100–150 cm) quality of manual compressions was significantly worse than mechanical compressions for mean compression depth (p < 0.05) and compression frequency (p < 0.05), percentage correct compression depth (p < 0.05), percentage of not leaning on the thorax (p < 0.05), and hands off time (p < 0.05). Crewmembers could only perform CPR for a limited time-period (sea-conditions/seasickness) and after one set of five epochs measurements were halted. In weather-condition two (wind ~9 Beaufort/wave-height ~200 cm) similar results were found during two epochs, after which measurements were halted (sea-conditions/seasickness). In weather-condition three (wind ~7 Beaufort/wave-height ~300–400 cm) MCD compressions were according to resuscitation-guidelines except for three epochs during which the MCD was displaced.

Conclusion

Crewmembers were only able to perform chest-compressions for a limited time because of the weather-conditions. The MCD was able to provide good quality chest compressions during all but three epochs during the study period. More research is needed to determine whether MCD-use in real-life circumstances improves outcome. Inclusion of data on use of a MCD on lifeboats should be considered in future revisions of the USFD and resuscitation guidelines.
Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors
Authors: Enguita Jose María , Díaz Ignacio , García Diego , Cubiella Tamara , Chiara María-Dolores , Valdés Nuria
Published: June 2023

Introduction

Paragangliomas (PGL), a type of neuroendocrine tumor, pose a significant diagnostic challenge due to their potential for unpredictable locations and asymptomatic presentation. Misdiagnosis of peripancreatic PGLs, particularly as pancreatic neuroendocrine tumors (PANNETs), is a pressing issue as it can negatively impact both pre- and post-treatment decision-making. The aim of our study was to identify microRNA markers for the reliable differential diagnosis of peripancreatic PGLs and PANNETs, addressing a crucial unmet need in the field and advancing the standard of care for these patients.

Methods

Morphing projections tool was used to analyze miRNA data from PGL and PANNET tumors present in the TCGA database. The findings were validated using two additional databases: GSE29742 and GSE73367.

Results

Our research uncovered substantial differences in the miRNA expression profiles of PGL and PANNET, leading to the identification of 6 key miRNAs (miR-10b-3p, miR-10b-5p, and the miRNA families miR-200c/141 and miR-194/192) that can effectively differentiate between the two types of tumors.

Discussion

These miRNA levels hold potential as biomarkers for improved diagnosis, offering a solution to the diagnostic challenge posed by these tumors and potentially improving the standard of care for patients.
The association between vitamin D supplementation and the long-term prognosis of differentiated thyroid cancer patients: a retrospective observational cohort study with propensity score matching
Authors: Ahn Jong-hyuk , Choi Hoonsung , Kim Su-jin , Cho Sun Wook , Lee Kyu Eun , Park Do Joon , Park Young Joo
Published: June 2023

Objective

Benefits of vitamin D in various cancers have been reported, but its effects on differentiated thyroid cancer (DTC) have not been established. We aimed to analyze the effect of vitamin D supplementation on the prognosis of DTC.

Methods

A retrospective observational cohort study was conducted on 9,739 DTC patients who underwent thyroidectomy from January 1997 to December 2016. Mortality was classified as all-cause, cancer-related, or thyroid cancer-related. Patients were divided into the “VD group” (supplemented with vitamin D) and the “control group” (without vitamin D supplementation). Propensity score matching was performed in a 1:1 ratio according to age, sex, tumor size, extrathyroidal extension (ETE), and lymph node metastasis (LNM) status, and 3,238 patients were assigned to each group. Kaplan-Meier curves, log-rank test and Cox proportional hazards regression analysis were performed.

Results

The follow-up period was 10.7 ± 4.2 years. Clinicopathological variables between two groups were similar except for all-cause (p<0.001) and total cancer death (p=0.001). From the Kaplan−Meier curve and log-rank test, “VD group” had significantly favorable all-cause (p<0.001) and total cancer mortality (p=0.003), but similar thyroid cancer mortality (p=0.23). In Cox regression, vitamin D intake reduced the risk of all-cause (hazard ratio [HR], 0.617, p=0.001) and total cancer mortality (HR, 0.668, p=0.016) but had no effect on thyroid cancer mortality.

Discussion/conclusion

Vitamin D supplementation was positively associated with all-cause and total cancer mortality in DTC and might be a modifiable prognostic factor for improved survival. Further research will be needed to clarify the effect of vitamin D supplementation on DTC.
A signature based on anoikis-related genes for the evaluation of prognosis, immunoinfiltration, mutation, and therapeutic response in ovarian cancer
Authors: Duan Yiqi , Xu Xiao
Published: June 2023

Background

Ovarian cancer (OC) is a highly lethal and aggressive gynecologic cancer, with an overall survival rate that has shown little improvement over the decades. Robust models are urgently needed to distinguish high-risk cases and predict reliable treatment options for OC. Although anoikis-related genes (ARGs) have been reported to contribute to tumor growth and metastasis, their prognostic value in OC remains unknown. The purpose of this study was to construct an ARG pair (ARGP)-based prognostic signature for patients with OC and elucidate the potential mechanism underlying the involvement of ARGs in OC progression.

Methods

The RNA-sequencing and clinical information data of OC patients were obtained from The Center Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. A novel algorithm based on pairwise comparison was utilized to select ARGPs, followed by the Least Absolute Shrinkage and Selection Operator Cox analysis to construct a prognostic signature. The predictive ability of the model was validated using an external dataset, a receiver operating characteristic curve, and stratification analysis. The immune microenvironment and the proportion of immune cells were analyzed in high- and low-risk OC cases using seven algorithms. Gene set enrichment analysis and weighted gene co-expression network analysis were performed to investigate the potential mechanisms of ARGs in OC occurrence and prognosis.

Results

The 19-ARGP signature was identified as an important prognostic predictor for 1-, 2-, and 3-year overall survival of patients with OC. Gene function enrichment analysis showed that the high-risk group was characterized by the infiltration of immunosuppressive cells and the enrichment of adherence-related signaling pathway, suggesting that ARGs were involved in OC progression by mediating immune escape and tumor metastasis.

Conclusion

We constructed a reliable ARGP prognostic signature of OC, and our findings suggested that ARGs exerted a vital interplay in OC immune microenvironment and therapeutic response. These insights provided valuable information regarding the molecular mechanisms underlying this disease and potential targeted therapies.
Performance of artificial intelligence in diabetic retinopathy screening: a systematic review and meta-analysis of prospective studies
Authors: Wang Zhibin , Li Zhaojin , Li Kunyue , Mu Siyuan , Zhou Xiaorui , Di Yu
Published: June 2023

Aims

To systematically evaluate the diagnostic value of an artificial intelligence (AI) algorithm model for various types of diabetic retinopathy (DR) in prospective studies over the previous five years, and to explore the factors affecting its diagnostic effectiveness.

Materials and methods

A search was conducted in Cochrane Library, Embase, Web of Science, PubMed, and IEEE databases to collect prospective studies on AI models for the diagnosis of DR from January 2017 to December 2022. We used QUADAS-2 to evaluate the risk of bias in the included studies. Meta-analysis was performed using MetaDiSc and STATA 14.0 software to calculate the combined sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of various types of DR. Diagnostic odds ratios, summary receiver operating characteristic (SROC) plots, coupled forest plots, and subgroup analysis were performed according to the DR categories, patient source, region of study, and quality of literature, image, and algorithm.

Results

Finally, 21 studies were included. Meta-analysis showed that the pooled sensitivity, specificity, pooled positive likelihood ratio, pooled negative likelihood ratio, area under the curve, Cochrane Q index, and pooled diagnostic odds ratio of AI model for the diagnosis of DR were 0.880 (0.875-0.884), 0.912 (0.99-0.913), 13.021 (10.738-15.789), 0.083 (0.061-0.112), 0.9798, 0.9388, and 206.80 (124.82-342.63), respectively. The DR categories, patient source, region of study, sample size, quality of literature, image, and algorithm may affect the diagnostic efficiency of AI for DR.

Conclusion

AI model has a clear diagnostic value for DR, but it is influenced by many factors that deserve further study.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, identifier CRD42023389687.