bluuebunny/crossref_metadata_2025 huggingface dataset:
The Trend of Interpersonal Violence Mortality at National and Provincial Levels in Iran From 1990 to 2015
Authors: Amanat Man , Naghdi Khatereh , Saeedi Moghaddam Sahar , Ahmadi Naser , Rezaei Nazila , Saadat Soheil , Salehi Mona , Mehdipour Parinaz , Khosravi Sepehr , Kianian Farzaneh , Forootan Elmira , Hosseini Elnaz , Ghodsi Zahra , Sadeghian Farideh , Sharif-Alhoseini Mahdi , Jazayeri Seyed Behzad , Derakhshan Pegah , Amirzade-Iranaq Mohammad Hosein , Salamati Payman , Mokdad Ali H. , O’Reilly Gerard , Moradi-Lakeh Maziar , Rahimi-Movaghar Vafa
Published: October 2019

Interpersonal violence (IPV) is a major public health concern with a significant impact on physical and mental health. This study was designed to evaluate age–sex-specific IPV mortality trends and the assault mechanisms (firearm, sharp objects, and other means), at national and provincial levels, in Iran. We used the Iranian Death Registration System (DRS) and the population and housing censuses in this analysis. Spatio-temporal and Gaussian Process Regression methods were used to adjust for inconsistencies at the provincial level and to integrate data from various sources. After assessing their validity, all records were reclassified according to the International Classification of Diseases, 10th Revision (ICD-10). All ICD-10 codes were then mapped to Global Burden of Disease (GBD) 2013 coding. More than 700 individuals died due to IPV in 1990 and more than twice this number in 2015. The IPV mortality age-standardized rate, per 100,000, increased from 1.62 (95% Uncertainty Interval [UI] = [0.96, 2.75]) in 1990 to 1.81 [1.15, 2.89] in 2015. Among females, the age-standardized mortality rate at national level per 100,000 due to IPV was 1.27 [0.66, 2.43] in 1990 and decreased to 1.08 [0.60, 1.96] in 2015. Among males, the age-standardized mortality rate was 1.96 [1.25, 3.09] in 1990 rising to 2.54 [1.70, 3.82] in 2015. Data from provinces revealed that during the period of our study, Hormozgan province had the largest increase of IPV among females, and Fars province had the largest increase of IPV among males. Conversely, the largest decrease was detected in West Azarbaijan and Qom provinces in females and males, respectively. This study showed a wide variation in the incidence and trends of IPV in Iran by age, sex, and location. The study has provided valuable information to reduce the burden of IPV in Iran and a means to monitor future progress through repeated analyses of the trends.
Nonlinear modeling and verification of an electromagnetic actuator with consideration of friction
Authors: Zuo Shuguang , Zhou Dawei , Hu Kun
Published: October 2019

To acquire a perfect vibration isolating performance in the active controlled mount system, a precise model for the actuator is required. In this study, we introduce a novel nonlinear lumped parameter model of the electromagnetic actuator for the engine’s idling or low-speed condition. The model considers not only the nonlinear characteristics caused by the reluctant force, cogging force, and magnetic saturation but also the friction between the mover and the supporting parts. The LuGre friction model is employed to describe the friction during the mover’s reciprocating motion. Then, the quasi-static actuator force of the electromagnetic actuator under constant currents is measured to identify the nonlinear parameters of the model, so is the nonstationary actuator force measured to identify the parameters of the LuGre friction model. Finally, a specific experimental scheme is proposed for validation, in which a suspended ring-shaped iron is added as the actuator’s load. This configuration limits the displacement of the mover effectively, allowing the actuator operate at a frequency of 20–50 Hz and at a peak actuator force of about 8 N, which is close to the actual working condition of the active controlled mount in the engine’s idling or low-speed condition. The results show that the proposed lumped parameter model is able to predict the dynamic characteristics of the actuator precisely. The root mean square errors of the current and actuator force are relatively 3% and 10%, respectively.
Characterization of drag reduction performance over rotating microgrooves with different cross-sections
Authors: Wen Suping , Wang Wenbo , Zhang Zhixuan
Published: October 2019

This paper presents a study of cross-sectional parameters and optimal drag reduction performance specifically for drag reduction in rotating microgroove applications. Rotating triangular microgrooves with nine asymmetrical and symmetrical cross-sections were numerically studied. In addition, a representative symmetrical rotating microgroove was experimentally tested. Positive asymmetrical microgrooves (including symmetrical microgrooves) were found to be sensitive to rotating Reynolds numbers and produced more significant drag reduction. Compared with a dimensioned asymmetry variable and other dimensionless parameters, the dimensionless asymmetry variable i+ could be used to describe drag reduction performance, which captured both the influence of microgroove cross-sectional asymmetry and turbulence intensity. A maximum drag reduction of up to 8.9% was obtained at 9.2 i+. With the exception of the torque, the velocity shift obtained from dimensionless velocity profiles could also be used to predict drag reduction performance, which has the potential for wider and more comprehensive application for any drag reduction technology.
Sigmund Freud and Martin Pappenheim
Authors: Jevremović Petar
Published: October 2019

During World War I, Martin Pappenheim, as a young doctor in the field of neurology and psychiatry, studied various possible consequences of war traumas, perhaps as part of a wider project of the Austro-Hungarian monarchy’s army. He visited military hospitals, sanatoriums and prisons, and between February and June 1916, while residing in Terezin, he had several opportunities to talk with Gavrilo Princip, who was imprisoned there. Princip was a young Bosnian Serb who had assassinated Archduke Franz Ferdinand of Austria and his wife, Sophie, in Sarajevo on 28 June 1914. There is written evidence of Pappenheim’s conversations with Princip; they were first published in Vienna 1926. My article is concerned with the possibility of Pappenheim’s influence on the later development of Freud’s theory.
Type I interferon gene signature test–low and –high patients with systemic lupus erythematosus have distinct gene expression signatures
Authors: Brohawn PZ , Streicher K , Higgs B W , Morehouse C , Liu H , Illei G , Ranade K
Published: October 2019

Objectives

Type I interferon (IFN) is implicated in systemic lupus erythematosus (SLE) pathogenesis. We aimed to identify type I IFN signaling-dependent and -independent molecular pathways in a large population of patients with SLE.

Methods

Baseline blood samples from adult patients with moderate to severe SLE from two Phase IIb studies (NCT01438489, n = 265; NCT01283139, n = 416) were profiled using whole transcriptome array analyses. Type I IFN gene signature (IFNGS) test status (high or low) was determined using a validated qualitative polymerase chain reaction–based test. IFN-type-specific signatures were developed by stimulating healthy blood with IFN-β, IFN-γ, IFN-λ, IFN-ω, or pooled IFN-α. These, and multiple literature-derived cell type and cytokine pathway signatures, were evaluated in individual and pooled study populations. A Fisher’s exact test was used for associations, adjusted for false discovery rate.

Results

Whole blood samples from IFNGS test–high patients were enriched versus IFNGS test–low patients for CD40L signaling ( Q < 0.001), CXC cytokine ( Q < 0.001), TLR8-mediated monocyte activation ( Q < 0.001), IgG ( Q < 0.001), major histocompatibility complex class I ( Q < 0.001), and plasma cell ( Q < 0.001) gene expression signatures. IFNGS test–low patients had significant enrichment of eosinophil ( Q < 0.001), IFN-γ-specific ( Q = 0.005), and T-cell or B-cell ( Q < 0.001) signatures. Similar enrichment profiles were demonstrated in patients with primary Sjögren’s syndrome, systemic sclerosis, and dermatomyositis.

Conclusions

IFNGS test–high patients overexpressed many gene signatures associated with SLE pathogenesis compared with IFNGS test–low patients, reflecting broad immune activation. These results provide new insights into the molecular heterogeneity underlying SLE pathogenesis, highlighting shared mechanisms beyond type I IFN, across several autoimmune diseases.

Trial registration

Clinicaltrials.gov: NCT01438489 and NCT01283139.
But Can They Write? Television News Industry Assessment of the Skills of Broadcast Journalism Students and Recent Graduates
Authors: Eschenfelder Christine C.
Published: October 2019

Broadcast journalism writing and reporting classes are designed to help students develop writing skills for multiple platforms, but many television news professionals think student writing and other necessary skills for the industry need improvement. Television news anchors, reporters, producers, and news directors who completed an online survey found many students need improvement in areas including writing skills, finding story ideas, storytelling, and writing to deadline. Survey participants also identified the need for robust internships and instructors with relevant skills and training. The purpose of this essay is to explore the survey comments which offer suggestions for both the academy and industry to improve multimedia student outcomes.
Intra- and inter-rater reliability in the cross-sectional area of feline lumbar epaxial musculature evaluated via abdominal CT scan
Authors: Rayhel Laura H , Quimby Jessica M , Green Eric M , Parker Valerie J , Bai Shasha
Published: October 2019

Objectives

The aim of this study was to evaluate the intra- and inter-rater reliability of epaxial muscle cross-sectional area measurement on feline CT images and to determine the relationship between normalized epaxial muscle area (EMA) and subjective muscle condition score (MCS).

Methods

Feline transverse CT images including the junction of the 13th thoracic vertebrae/13th rib head were retrospectively reviewed. Right and left epaxial muscle circumference and vertebral body height were measured and an average normalized EMA (ratio of epaxial area:vertebral height) was calculated for each image. Measurements were performed by three individuals blinded to the clinical data and were repeated 1 month later. Intra- and inter-rater reliability of EMA was assessed with concordance correlation coefficient (CCC), and Bland–Altman analysis was performed to assess bias and limits of agreement (LoA) between and within observers at different time points. In cats for which MCS data were available, EMA was compared between differing MCSs via the Kruskal–Wallis test, with Bonferroni-corrected Wilcoxon rank-sum post-hoc analysis.

Results

In total, 101 CT scans met the inclusion criteria for reliability analysis, 29 of which had muscle condition information available for analysis. Intra-rater EMA CCC ranged from 0.84 to 0.99 with minimal bias (range –0.16 to 0.08) and narrow LoA. Inter-rater EMA CCC ranged from 0.87 to 0.94, bias was larger (range –0.46 to 0.66) and LoA were wider when assessed between observers. Median EMA was significantly lower in cats with severe muscle atrophy (2.76, range 1.28–3.96) than in all other MCS groups ( P <0.0001 for all comparisons).

Conclusions and relevance

Measurement of EMA on CT showed strong intra-rater reliability, and median EMA measurements were significantly lower in cats with severe muscle wasting, as assessed on physical examination. Further studies correlating EMA to lean muscle mass in cats are needed to determine whether this method may be useful to quantify muscle mass in patients undergoing a CT scan.
Collaborative institutional work to generate alternative food systems
Authors: Michel Sophie
Published: October 2019

Recently, there has been a proliferation of alternatives to the global food system. Yet, there is still an ongoing debate on their potential to transform the food system and challenge its globalization. This research introduces institutional analysis to the food system literature in order to comprehend actors’ efforts to scale up alternatives and transform the food system at the local level. Such efforts are explored from an inductive research of the organization called M-Local Food Project, which gathers a range of diverse actors to work on expanding alternative food and transforming the food system in eastern France. Based on this organization’s analysis and its collaborative institutional work, this research highlights how to organize collective agency from the collaboration of multiple actors to co-build an alternative food system and extends the debate on alternative food potential to challenge the dominant global food system. It also provides an emerging model of collaborative institutional work that enriches the institutional analysis on the coalition for institutional changes and offers practical advice on tensions for alternative organizations that cannot be overcome.
Banishing dominance in Europe: The case for regional cosmopolitanism
Authors: Eriksen Erik O
Published: October 2019

How is arbitrary rule – dominance – to be avoided when political differentiation is on the rise in the multilevel constellation that makes up the European Union? The EU is a power-wielding entity, that, due to its democratic deficits, is an instance of arbitrary rule, which differentiation only serves to exacerbate. This article discusses which political framework prevents dominance under conditions of asymmetric and complex interdependence, and economic integration in Europe. Under these conditions, the framework of international law is deficient, as the agreements with the associated non-members – the European Economic Area Agreement (EEA) and Switzerland – document. Here dominance appears to be self-incurred but nevertheless in breach with political freedom. Another is the framework suggested by Jürgen Habermas, of a pouvoir constituant mixte. Also, this framework raises the danger of arbitrary rule, as there is a risk that the autonomy of citizens would be pre-empted by the sovereignty of their states. The article holds the framework of a regional cosmopolitan federation – a rights-based polity with a distinct territorial reach – as more promising.
Can you tell by their English if they can speak Welsh? Accent perception in a language contact situation
Authors: Mayr Robert , Roberts Llian , Morris Jonathan
Published: October 2019

Aims:

The purpose of this research was to gain a better understanding of accent perception in language contact situations in which monolingual speakers of a contact variety and bilinguals live in the same community.

Design:

We investigated the English accents of monolinguals and bilinguals from the same area in South-West Wales, and listeners’ perceptions thereof, in three inter-related studies.

Data:

In Study 1, an accent perception experiment, participants from four different listener groups were asked to differentiate English monolinguals and Welsh–English bilinguals on the basis of short English speech samples. In Study 2, the same participants’ views about differences between the accentual features of monolinguals and bilinguals were examined in individual structured interviews. Finally, in Study 3, the speech samples from the accent perception experiment were analysed phonetically based on the accentual features mentioned in Study 2.

Findings:

Study 1 revealed that monolinguals and bilinguals can be identified above chance based on their English accent, but performance was unexceptional. Identification was better with greater accent familiarity, but unrelated to the listener’s ability to speak Welsh. Study 2 revealed the specific segmental and suprasegmental features that the listeners considered indicative of monolingual and bilingual speakers’ English accents, while Study 3 showed that only some of the listeners’ views are consistent with the production data from Study 1.

Originality:

This paper is the first to examine whether monolinguals and bilinguals from a bilingual area with historical language contact can be identified on the basis of their majority language accent, and on what grounds these identifications are made.

Implications:

This research shows that settings in which minority-language features originate from both historical language contact and individual bilingualism yield subtle accentual differences in the majority language between monolinguals and bilinguals to which even listeners from the same accent background may not be responsive.
Intergroup relational identity: Development and validation of a scale and construct
Authors: Rast David E. , van Knippenberg Daan , Hogg Michael A.
Published: October 2019

In their theory of intergroup leadership, Hogg, van Knippenberg, and Rast proposed the novel concept of intergroup relational identity. An intergroup relational identity (IRI) refers to a form of social identity that is defined in terms of the cooperative and mutually promotive relationship between subgroups. This article outlines the development of a five-item scale to measure IRI. We conducted five studies with over 1,700 participants from different countries. The unidimensional factor structure of the five-item scale replicated across studies, and the latter three studies provided evidence of construct (convergent and discriminant) and criterion-related validity. Intergroup relations are often overlooked in organizational behavior and management research. However, our results support the idea that IRI affects intergroup or inter-team cooperation and collaboration, as well as leadership effectiveness—enhanced perceptions of an IRI is a promising way to reduce conflict between subgroups within a larger collective. To date, no measure of IRI has been published. These studies present the first empirical test of and support for the newly developed IRI measure, and provide evidence demonstrating the benefit of promoting an IRI for both leadership and intergroup relations more broadly.
Estimation of extremes of non-Gaussian wind pressure on building roof: Sampling error in moment-based translation process model with no monotonic limit
Authors: Wu Fengbo , Liu Min , Yang Qingshan , Peng Liuliu
Published: October 2019

Estimation of extremes of non-Gaussian wind pressure on building roof is necessary for cladding design. When limited length of non-Gaussian wind pressure is used for calculation, the estimated extreme involves sampling error. The moment-based Hermite polynomial model is extensively applied for estimation of extreme wind pressure due to the straightforwardness and accuracy, however, Hermite polynomial model has a monotonic limit resulting in a restricted application region of skewness and kurtosis combination. However, another two moment-based translation process models with no monotonic limit including Johnson transformation model and piecewise Hermite polynomial model have attracted some attention as these two models can be applied to a broader region of skewness and kurtosis combination. The sampling error in estimation of extremes of non-Gaussian wind pressure on building roof by Hermite polynomial model is proposed in the literature recently. Nevertheless, the sampling errors in Johnson transformation model and piecewise Hermite polynomial model have not been addressed. In this study, sampling errors in estimation of extremes of non-Gaussian wind pressures by Johnson transformation model are investigated. Formulations for estimating sampling errors of newly defined statistical moments and subsequent extremes in piecewise Hermite polynomial model are presented. The performance of sampling errors in Hermite polynomial model, Johnson transformation model, and piecewise Hermite polynomial model are finally compared with each other. Based on very long wind pressures from wind tunnel tests, it is shown that the sampling error of minimum wind pressure (suction) in Hermite polynomial model is generally the smallest compared to Johnson transformation model and piecewise Hermite polynomial model, while that of maximum wind pressure in piecewise Hermite polynomial model seems to be the smallest.
An evidence-based strategy to achieve equivalency and interoperability for social-behavioral determinants of health assessment, storage, exchange, and use
Authors: Wetta Ruth E , Severin Roberta D , Gruhler Heidi
Published: October 2019

The interoperable exchange of social-behavioral determinants of health data is challenging due to complex factors including multiple recommendations, multiple tools with varying domains, scoring, and cutpoints, and lack of terminology code sets for storing assessments and findings. This article describes a strategy that permits scoring by social-behavioral determinants of health domain to create interoperability and equivalency across tools, settings, and populations. The three-tier scoring strategy converts social-behavioral determinants of health data to (1) be used immediately at point of care by identifying social needs or social risk factors, (2) be consumed within analytics and algorithms and for secondary analysis, and (3) produce total scores that reflect social determinant burden and behavioral determinant burden across populations and settings within a healthcare system. The strategy supports the six uses recommended by the National Academy of Medicine, provides flexibility in choice of social-behavioral determinants of health tool, and leverages the power of social-behavioral determinants of health data in healthcare delivery.
A new institution on the block: On platform urbanism and Airbnb citizenship
Authors: van Doorn Niels
Published: October 2019

This article argues that Airbnb should be understood as a new urban institution that is transforming relations between market, state, and civil society actors. Taking the Airbnb Citizen advocacy initiative as my case, I examine how this transnational “home sharing” platform achieves such transformations, which in turn requires an investigation into the specific nature of Airbnb as an institutional form. Assuming the agenda-setting role of the urban “regulatory entrepreneur,” Airbnb aims to co-shape the terms of current and future policy debates pertaining not just to home sharing/short-term rental but also to the very fabric of city life. It pursues this mode of “platform urbanism” by mobilizing its user base, which it frames as a community of entrepreneurial middle-class citizens looking to supplement their income in a climate of economic insecurity and tech-enabled opportunity. Yet, who is the “Airbnb Citizen” and what are the opportunities and risks associated with platform-mediated citizenship?
An intelligent diagnostic and prognostic framework for large-scale rotating machinery in the presence of scarce failure data
Authors: Li Xiaochuan , Yang Xiaoyu , Yang Yingjie , Bennett Ian , Mba David
Published: October 2019

In this work, a novel diagnostic and prognostic framework is proposed to detect faults and predict remaining service life of large-scale rotating machinery in the presence of scarce failure data. In the proposed framework, a canonical variate residuals–based diagnostic method is developed to facilitate remaining service life prediction by continuously implementing detection of the prediction start time. A novel two-step prognostic feature exploring approach that involves fault identification, feature extraction, feature selection and multi-feature fusion is put forward. Most existing prognostic methods lack a fault-identification module to automatically identify the fault root-cause variables required in the subsequent prognostic analysis and decision-making process. The proposed prognostic feature exploring method overcomes this challenge by introducing a canonical variate residuals–based fault-identification method. With this method, the most representative degradation features are extracted from only the fault root-cause variables, thereby facilitating machinery prognostics by ensuring accurate estimates. Its effectiveness is demonstrated for slow involving faults in two case studies of an operational industrial centrifugal pump. Moreover, an enhanced grey model approach is developed for remaining useful life prediction. In particular, the empirical Bayesian algorithm is employed to improve the traditional grey forecasting model in terms of quantifying the uncertainty of remaining service life in a probabilistic form and improving its prediction accuracy. To demonstrate the superiority of empirical Bayesian–grey model, existing prognostic methods such as grey model, particle filter–grey model and empirical Bayesian–exponential regression are also utilized to realize machinery remaining service life prediction, and the results are compared with that of the proposed method. The achieved predictive accuracy shows that the proposed approach outperforms its counterparts and is highly applicable in fault prognostics of industrial rotating machinery. The use of in-service data in a practical scenario shows that the proposed prognostic approach is a promising tool for online health monitoring.
Community-Based Social Marketing—Creating Lasting, Sustainable, Environmental Change: Case Study of a Household Stormwater Management Program in the Region of Waterloo, Ontario
Authors: Smith Lauren Keira Marie , Lynes Jennifer Kristin , Wolfe S. E.
Published: October 2019

With increased frequency of extreme weather events due to climate change, there is growing need for urban, small-scale adaptation and preventative measures such as stormwater management to reduce the risk of flooding. Homeowners are often reluctant to adopt preventative stormwater measures without tangible benefits or direct experience with the flooding risks or other negative externalities. Using community-based social marketing (CBSM) as a framework, we investigated how to more effectively encourage stormwater management at the household level. In collaboration with the Canadian non-profit organization, Reep Green Solutions (Region of Waterloo, Ontario), we focused on an existing program, the RAIN Home Visit (RHV), which was designed to increase engagement in pro-environmental stormwater management behaviors. Reports from the RHV were assessed, and past program participants were interviewed using a semi-structured question set to identify barriers encountered in enacting these behaviors and to assess the program for inclusion of CBSM principles and tools. Surveys were used to collect demographic data from participants. We found that while preferred behaviors were explained and incentives were provided, more thorough, clear explanation was needed for homeowners as well as incentives of suitable size and value to effectively motivate homeowners to change. Key features that should be included in future RHV programs are public commitments, follow-up, and reminders. Further research should consider risk perception impacts with CBSM, to determine how these can work together and, perhaps, which precedes the other. Some people may be more influenced by social norms to act and others by risk perception.
Different Sameness: Queer Autoethnography and Coalition Politics
Authors: Spieldenner Andrew R. , Eguchi Shinsuke
Published: October 2019

As a method, we use autoethnography to explore coalition politics from our positions in academia. We use autoethnography to examine how similar identity categories presume sameness and can lead to conflict within institutions. This autoethnography looks at how coalitional politics were learned, as well as how coalitional politics are practiced within the institutional spaces of the university and academic discipline. In particular, we examine how we have experienced conflict and competition, as well as ways that we continue to build coalitional spaces. Through this, we place autoethnography as an explicitly political methodology.
Effect of Chinese Herbal Medicine on the Survival of Colorectal Cancer Patients With Liver-Limited Metastases: A Retrospective Cohort Study, 2008 to 2017
Authors: Shao Cui , Zuo Qian , Lin Jietao , Yu Rong Jian , Fu Yuanfeng , Xiao Min , Sun Ling Ling , Lin Lizhu
Published: October 2019

Background: Colorectal cancer (CRC) remains one of the leading contributors to cancer-related mortality and morbidity worldwide. Traditional Chinese medicines have been widely employed to treat various types of cancer in China. This investigation aims to determine the association between Chinese herbal medicine (CHM) therapy and survival outcomes in CRC patients with liver-limited metastases. Methods: A retrospective cohort study was performed among patients with colorectal liver metastases at the First Affiliated Hospital of Guangzhou University of Chinese Medicine in Guangzhou, China. Data from a series of consecutive patients were collected via an electronic medical record system or telephone follow-up. We defined high exposure as a period of CHM therapy lasting more than 6 months. The primary outcome was overall survival. Results: The study included the data of 191 patients from January 2008 to December 2017; 126 patients (65.97%) met the inclusion criteria of high exposure to CHM. Multivariate analyses revealed that high exposure to CHM was associated with better overall survival (hazard ratio = 0.444, 95% confidence interval = [0.213, 0.926], P = .030). The association was further confirmed by a subgroup exploratory analysis. Conclusion: Long-term CHM therapy is correlated with improved survival outcomes in CRC patients with liver-limited metastases.
Cognitive–Motor Impairment in Manual Tasks in Adults With Type 2 Diabetes
Authors: Gorniak Stacey L. , Ray Haley , Lee Beom-Chan , Wang Jing
Published: October 2019

Adults with type 2 diabetes (T2D) experience decline in cognitive function compared with controls. Cognitive function is a major component in the performance of daily activities that involve motor components. The aim of this project was to evaluate working memory cognitive deficits and sensorimotor deficits in adults with T2D versus healthy participants. Ten community-dwelling persons with T2D and 10 age- and sex-matched healthy controls were recruited. Cognitive function, tactile function, motor function, and health state measures were evaluated. Reduced cognitive function, tactile function, and motor function were exhibited in the T2D group. Cognitive and motor functions remained impaired versus controls during tasks with both cognitive and motor components (dual tasks). Health state measures were found to covary with measures of interest. The conclusions of this article are as follows: (a) systemic deficits beyond tactile dysfunction contribute to reduced hand/finger function in T2D, and (b) participants with T2D demonstrate impairments in working memory, tactile function, and motor function.
Cognition in Stroke Rehabilitation and Recovery Research: Consensus-Based Core Recommendations From the Second Stroke Recovery and Rehabilitation Roundtable
Authors: McDonald Matthew W. , Black Sandra E. , Copland David A. , Corbett Dale , Dijkhuizen Rick M. , Farr Tracy D. , Jeffers Matthew S. , Kalaria Rajesh N. , Karayanidis Frini , Leff Alexander P. , Nithianantharajah Jess , Pendlebury Sarah , Quinn Terence J. , Clarkson Andrew N. , O’Sullivan Michael J.
Published: October 2019

Cognitive impairment is an important target for rehabilitation as it is common following stroke, is associated with reduced quality of life and interferes with motor and other types of recovery interventions. Cognitive function following stroke was identified as an important, but relatively neglected area during the first Stroke Recovery and Rehabilitation Roundtable (SRRR I), leading to a Cognition Working Group being convened as part of SRRR II. There is currently insufficient evidence to build consensus on specific approaches to cognitive rehabilitation. However, we present recommendations on the integration of cognitive assessments into stroke recovery studies generally and define priorities for ongoing and future research for stroke recovery and rehabilitation. A number of promising interventions are ready to be taken forward to trials to tackle the gap in evidence for cognitive rehabilitation. However, to accelerate progress requires that we coordinate efforts to tackle multiple gaps along the whole translational pathway.
A smart Internet of Things–based mechanism for wireless communications in NoC
Authors: Chi Tao , Chen Manman , Chen Ming , Yan Haowei
Published: October 2019

With the development of silicon integration technology, the network-on-chip (NoC) proposes a scalable communication architecture that can improve system performance. Future multi-core chips are expected to be heterogeneous and hierarchical in nature. Inter-frequency interference will occur between various 2.4-GHz wireless network communication cores integrated on the same chip, resulting in lower network throughput and higher communication latency. This article solves the problem of wireless co-channel mutual interference from the two aspects of time domain and frequency domain and designs a heterogeneous platform based on NoC architecture to achieve more stable parallel communication of multiple wireless co-frequency networks without mutual interference. When the system detects the interference, this article uses the chirped fractional Fourier transform to filter out the interference signal before the signal arrives and then spreads the frequency. According to the results, the method improves the anti-interference ability of the network and the utilization of spectrum resources. Compared with the traditional carrier sense multiple access method, the spectrum-aware channel cooperation method proposed in this article reduces the data average transmission delay by 0.02 s and the data packet reception rate is increased by about 30%, which provides a certain reference value for future wireless multi-core communication.
Inter-relationships of Metacarpals 1 to 5, Regarding Their Length, Metaphyseal Midshaft Width, Articular Surface Area of Head and Base, Age, and Sex: A Cadaveric Study
Authors: Sephien Andrew , Bethel Claire F. , Gulick Danielle , Nairn Christa , Ourn Felicia , Schwartz-Fernandes Francisco A.
Published: October 2019

Background: Metacarpal factures are common, comprising up to 50% of hand fractures. More work is needed to further our understanding of metacarpal anatomy to improve fixation techniques and reduce postoperative complications following surgical implants. The purpose of this anatomic study was to evaluate the length, midshaft metaphyseal width, and area of the articular surface of the head (AH) and base (AB) of metacarpals 1 to 5. Methods: This prospective study assessed measures from 17 cadavers at 1 institution’s anatomy lab. The anatomic dimensions of the metacarpals in both the right and left hands were measured. Epidemiological data including sex and age at death were also collected. Results: In all, 29 hands were dissected for metacarpal anatomic measurements, for a total of 145 metacarpals. The second metacarpal was longest, at 69.58 mm. Multivariate analysis of variance revealed a significant effect of sex overall, with greater metacarpal dimensions in men. Increasing age was associated with decreasing dimensions, except for AH of metacarpal 1 ( F = 3.43, P = .02) and AB of metacarpal 1 ( F = 11.54, P < .001) and 4 ( F = 4.21, P = .01). Multiple metacarpal dimensions were also significantly correlated with each other. Conclusion: Our data reveal further information regarding metacarpal dimensions of length, midshaft width, and AH and AB. The results allow for potential to improve surgical management through improving metacarpal implants, developing an optimal plate and screw design, techniques to better accommodate anatomical differences based on age and sex, reducing postoperative complications and improving the standard of care.
The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer
Authors: Liu Chang , Wang Rensheng
Published: October 2019

Radiotherapy is an important treatment of cervical cancer, especially for advanced cervical cancer. According to research reports, Hedgehog signaling pathway plays an essential role in the growth, invasion, metastasis, recurrence, drug resistance, and radioresistance of cervical cancer. The components of Hedgehog signaling pathway could be biomarkers, related to progression and prognosis of cervical cancer. In addition, targeted therapy for Hedgehog signaling pathway is expected to become a new strategy for the treatment of radioresistant cervical cancer. This review summarizes the research status and progress of the relationship between radiation resistance and activation of Hedgehog signaling pathway in cervical cancer.
The effect of conditioned inhibitors and preexposed cues on the outcome-specific Pavlovian-to-instrumental transfer effect in humans
Authors: Alarcón Daniel E , Bonardi Charlotte
Published: October 2019

Using a human Pavlovian-to-instrumental transfer (PIT) task, Alarcón and Bonardi showed that the selective elevation of instrumental responding produced by excitatory transfer cues was reduced when these cues were presented with a conditioned inhibitor (CI), relative to a control cue that was simply preexposed. However, previous research has shown that preexposed cues might also acquire inhibitor-like properties. This study aimed to contrast the inhibitory properties of CIs and preexposed cues, using novel stimuli as controls, in summation and PIT tests. Participants were trained to perform two actions, each reinforced with a distinct outcome (O1 or O2). Two images were trained as CIs, each signalling the absence of one of the outcomes, by presenting them with a cue that was otherwise followed by that outcome (e.g., A→O1, AI→no O1). In contrast, the preexposed cues were simply presented in the absence of the outcomes. In the summation test, participants rated the likelihood of the outcomes in the presence of two independently trained excitatory cues, each presented with a CI, a preexposed cue, or a novel stimulus. Similarly, in the PIT test, participants performed both actions in the presence and absence of these compounds. In the summation test, the CIs and the preexposed cues reduced participants’ expectations of the outcomes more than the novel stimuli. However, in the PIT test, only the CIs reduced the selective elevation of responding produced by the transfer cues. These results might reflect distinct properties of stimuli trained as CIs and those simply preexposed.
Sorting through the impact of familiarity when processing vocal identity: Results from a voice sorting task
Authors: Stevenage Sarah V , Symons Ashley E , Fletcher Abi , Coen Chantelle
Published: October 2019

The present article reports on one experiment designed to examine the importance of familiarity when processing vocal identity. A voice sorting task was used with participants who were either personally familiar or unfamiliar with three speakers. The results suggested that familiarity supported both an ability to tell different instances of the same voice together, and to tell similar instances of different voices apart. In addition, the results suggested differences between the three speakers in terms of the extent to which they were confusable, underlining the importance of vocal characteristics and stimulus selection within behavioural tasks. The results are discussed with reference to existing debates regarding the nature of stored representations as familiarity develops, and the difficulty when processing voices over faces more generally.
Natural Language Processing and Futures Studies
Authors: Kehl Walter , Jackson Mike , Fergnani Alessandro
Published: October 2019

Because the input for Futures Studies is to a very high degree formulated as written words and texts, methods which automate the processing of texts can substantially help Futures Studies. At Shaping Tomorrow, we have developed a software system using Natural Language Processing (NLP), a subfield of Artificial Intelligence, which automatically analyzes publicly available texts and extracts future-relevant data from theses texts. This process can be used to study the futures. This article discusses this software system, explains how it works with a detailed example, and shows real-life applications and visualizations of the resulting data. The current state of this method is just the first step; a number of technological improvements and their possible benefits are explained. The implications of using this software system for the field of Futures Studies are mostly positive, but there are also a number of caveats.
Neurodevelopmental Outcomes Among Children With Congenital Heart Disease: At-Risk Populations and Modifiable Risk Factors
Authors: Ryan Kathleen R. , Jones Melissa B. , Allen Kiona Y. , Marino Bradley S. , Casey Frank , Wernovsky Gil , Lisanti Amy Jo
Published: October 2019

As survivable outcomes among patients with complex congenital heart disease (cCHD) have continued to improve over the last several decades, more attention is being dedicated to interventions that impact not just survival but quality of life among patients with cCHD. In particular, patients with cCHD are at risk for impaired neurodevelopmental outcomes. In this review summarizing select presentations given at the 14th Annual Pediatric Cardiac Intensive Care Society’s Annual Meeting in 2019, we discuss the neurodevelopmental phenotype of patients with cCHD, patients at greatest risk of impaired development, and three specific modifiable risk factors impacting development.
Incapacitated and Alone: Prevalence of Unbefriended Residents in Alberta Long-Term Care Homes
Authors: Chamberlain Stephanie A. , Duggleby Wendy , Fast Janet , Teaster Pamela B. , Estabrooks Carole A.
Published: October 2019

The objective of this study was to assess the prevalence of residents who are incapacitated and have no surrogate decision maker, known as the “unbefriended” in Alberta long-term care (LTC) homes. Using cross-sectional online survey methods, data were collected from 123 staff (i.e., directors of care/nursing, administrators) from Alberta LTC homes. Information was collected on survey respondents’ demographic characteristics, number of unbefriended residents, and on organizational characteristics. The overall prevalence of unbefriended residents in LTC homes was 4.14% in Alberta ( SD = 6.28%, range: 0%-34.6%). Homes with the highest prevalence (nearly 15%) of unbefriended residents had >135 beds and were public not-for-profit and located in large urban centers. Fifty-three percent of unbefriended residents were male. The highest prevalence of unbefriended residents lived in homes located in large urban centers and public not-for-profit operators. Population level and LTC home level prevalence data are needed to assess the scope of unmet needs.
A roundtable discussion: Defining urban data science
Authors:   Organizers, Kang Wei , Oshan Taylor , Wolf Levi J ,   Discussants, Boeing Geoff , Frias-Martinez Vanessa , Gao Song , Poorthuis Ate , Xu Wenfei
Published: October 2019

The field of urban analytics and city science has seen significant growth and development in the past 20 years. The rise of data science, both in industry and academia, has put new pressures on urban research, but has also allowed for new analytical possibilities. Because of the rapid growth and change in the field, terminology in urban analytics can be vague and unclear. This paper, an abridged synthesis of a panel discussion among scholars in Urban Data Science held at the 2019 American Association of Geographers Conference in Washington, D.C., outlines one discussion seeking a better sense of the conceptual, terminological, social, and ethical challenges faced by researchers in this emergent field. The panel outlines the difficulties of defining what is or is not urban data science, finding that good urban data science must have an expansive role in a successful discipline of “city science.” It suggests that “data science” has value as a “signaling” term in industrial or popular science applications, but which may not necessarily be well-understood within purely academic circles. The panel also discusses the normative value of doing urban data science, linking successful practice back to urban life. Overall, this panel report contributes to the wider discussion around urban analytics and city science and about the role of data science in this domain.
Efficacy and safety of CAR19/22 T-cell cocktail therapy in patients with refractory/relapsed B-cell malignancies
Authors: Wang Na , Hu Xuelian , Cao Wenyue , Li Chunrui , Xiao Yi , Cao Yang , Gu Chaojiang , Zhang Shangkun , Chen Liting , Cheng Jiali , Wang Gaoxiang , Zhou Xiaoxi , Zheng Miao , Mao Xia , Jiang Lijun , Wang Di , Wang Qiuxiang , Lou Yaoyao , Cai Haodong , Yan Dandan , Zhang Yicheng , Zhang Tongcun , Zhou Jianfeng , Huang Liang
Published: October 2019

Relapse following chemeric antigen receptor (CAR) T-cell therapy can arise from progressive loss of the CAR T cells or from loss of the target antigen by tumor cells. Wang et al report that using a mix of CAR T cells targeting CD19 and CD22 reduces relapse with antigen-negative tumor cells. However, a lack of CAR T-cell persistence leads to increased relapse with antigen-positive cells.
Implicit gender bias among US resident physicians
Authors: Hansen Matt , Schoonover Amanda , Skarica Barbara , Harrod Tabria , Bahr Nathan , Guise Jeanne-Marie
Published: October 2019

Background

The purpose of this study was to characterize implicit gender bias among residents in US Emergency Medicine and OB/GYN residencies.

Methods

We conducted a survey of all allopathic Emergency Medicine and OB/GYN residency programs including questions about leadership as well as an implicit association test (IAT) for unconscious gender bias. We used descriptive statistics to analyze the Likert-type survey responses and used standard IAT analysis methods. We conducted univariate and multivariate analyses to identify factors that were associated with implicit bias. We conducted a subgroup analysis of study sites involved in a multi-site intervention study to determine if responses were different in this group.

Results

Overall, 74% of the programs had at least one respondent. Out of 14,234 eligible, 1634 respondents completed the survey (11.5%). Of the five sites enrolled in the intervention study, 244 of 359 eligible residents completed the survey (68%). Male residents had a mean IAT score of 0.31 (SD 0.23) and females 0.14 (SD 0.24), both favoring males in leadership roles and the difference was statistically significant (p < 0.01). IAT scores did not differ by postgraduate year (PGY). Multivariable analysis of IAT score and participant demographics confirmed a significant association between female gender and lower IAT score. Explicit bias favoring males in leadership roles was associated with increased implicit bias favoring males in leadership roles (r = 0.1 p < 0.001).

Conclusions

We found that gender bias is present among US residents favoring men in leadership positions, this bias differs between male and female residents, and is associated with discipline. Implicit bias did not differ across training years, and is associated with explicit bias.
Correction to: A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1
Authors: Xia Xin , Li Xixi , Li Fanying , Wu Xujia , Zhang Maolei , Zhou Huangkai , Huang Nunu , Yang Xuesong , Xiao Feizhe , Liu Dawei , Yang Lixuan , Zhang Nu
Published: October 2019

In the published article [1], an error was noticed in Fig. 6B. The western blot results were reversed between the overexpression group and the knockdown group of circ-AKT3. The corrected and updated Fig. 6 is provided below. This error does not affect the findings or conclusions of the article.