bluuebunny/crossref_metadata_2025 huggingface dataset:
Análise dos métodos de avaliação geométrica de via permanente para monitoramento de via férrea no Brasil
Authors: Junqueira Angelo Samuel , Dos Santos Motta Rosângela , Oliveira Luciano
Published: April 2023

As ferrovias desempenham um papel importante na logística global, sendo utilizadas como um dos meios básicos e eficientes de transporte de mercadorias nas principais economias mundiais (ANTF, 2022b). A vias precisam ser monitoradas para garantir a segurança nas operações e economia na manutenção. Atualmente as inspeções são realizadas de maneira automática, conduzidas geralmente por carro-controle, que mensuram os parâmetros geométricos, a partir dos quais utiliza-se um índice para representála numericamente. Diversos índices de qualidade foram propostos em diferentes agências regulamentadoras, como European Railway Agency e Federal Railway Administration (FRA). Para as ferrovias brasileiras, não existe método normatizado de índice de qualidade da via próprio. Deste modo, o trabalho buscou entender e aplicar os métodos de avaliação geométrica da via permanente a partir de dados levantados em duas ferrovias brasileiras utilizando o equipamento de inspeção carro-controle, em vista da necessidade de entender os índices aplicados em ferrovias de outros países. Foram avaliados Track Quality Index (TQI) FRA, Standard Deviation (SD), índice TQI China, Coeficiente J e Combined Standard Deviation (CoSD). Além de verificar e discutir as metodologias aplicadas pelas ferrovias, será proposta uma metodologia existente única a ser aplicada em ferrovias no Brasil mediante a realização de um estudo de caso. A utilização de índice adequado pode favorecer a definição de um planejamento efetivo pela gerência de manutenção ferroviária, viabilizando um melhor controle da vida útil dos ativos, e por conseguinte, otimização no emprego de recursos. Portanto, foram avaliados para duas ferrovias, um trecho amostral, com suas respectivas classificações e os níveis de qualidade conforme os diferentes métodos disponíveis na literatura, a fim de aferir qual metodologia representou melhor a condição real da linha férrea destas ferrovias. Com isto foi possível obter um melhor entendimento do comportamento dos parâmetros que envolvem as ferrovias, além da compreensão, comparação e aplicabilidade dos diferentes métodos utilizando um mesmo conjunto de informações proveniente das inspeções realizadas pelo carro-controle. O trabalho sugere o emprego do método CoSD considerando os quatro parâmetros de geometria de via descritos em normativa técnica (NBR 16387, 2020) até a elaboração de um método adequado.
ENTERTAINMENT MEDIA AND THE CRISIS OF COMMUNICATION ETHICS IN AMBIGUOUS PHENOMENA (CASE STUDY OF PUBLIC FIGURE FEUD)
Authors: Parmadie Aliffarazzi Syaqki , Parmadie Baarrafizki Dilkindi
Published: April 2023

Purpose: The thing that is of concern here is that the feud that the public figure is showing then propagates to television as the mass media, while there is a possibility that the spectacle of this feud contains bad values that are not good for society. Cases that occur are also considered contrary to existing communication ethics. Another unfortunate thing is the reason why several public figures are competing with each other to take action like this so that it becomes a trend, and this is directly proportional to the interest of the Indonesian people to see this feud. The feud was also considered as entertainment for the community. According to data, internet users in Indonesia have reached 212 million in January 2023. This means that around 77% of Indonesia's population has used the internet.
Research methods: In this study the descriptive analytical method of phenomena was used to study an object in the context of people's behavior, conditions, systems of thought, and events at the present time. The approach method is a case study to reveal and describe the phenomenon of the subject and object of research on entertainment media and the crisis of communication ethics in the ambiguous phenomenon of public figure feud.
Findings: Public figures should be able to realize that they are in the spotlight in public spaces. Their communication in public spaces should be able to display self-control abilities, maturity in attitude, and responsibility in speech and behavior.
Implications: On the other hand, good understanding and awareness is needed by the public so that they are wiser in using the mass media. That way, there will be no shift in people's behavior in viewing communication ethics. Because, if we think about culture in Indonesia, it actually teaches good ways of communicating with others, without hurting or harming other parties.
Estudio sobre el consumo de alcohol en estudiantes universitarios
Authors:   Universidad Nacional de Córdoba, Carrazana Rivera Andrea , Zygadlo Andrea ,   Universidad Nacional de Córdoba
Published: April 2023

Según datos de la Encuesta Nacional de Factores de Riesgo (ENFR) 2013, los jóvenes de 18 a 24 años presentan las prevalencias más elevadas de consumo de alcohol, mostrando que los patrones de consumo riesgosos no afectan de la misma manera a todos los segmentos de la población a pesar de estar enfrentando al mismo mercado y las mismas regulaciones. La disponibilidad de datos comparables internacionalmente y la información detallada sobre el fenómeno a prevenir es crucial para el diseño de políticas públicas. Este trabajo tiene como objetivo realizar un análisis descriptivo preliminar sobre el consumo de alcohol en la población estudiantil de la Universidad Nacional de Cuyo y la Universidad Nacional de Córdoba. Los datos provienen de la Encuesta de Hábitos de Consumo realizada en agosto de 2019 (Obs. = 1397). Las estadísticas descriptivas generales muestran información sobre los hábitos de consumo, la propensión y acceso al alcohol y otras sustancias, la influencia de la conducta de pares y familiares en cuanto al consumo de alcohol y otras sustancias, el riesgo que perciben por el consumo propio de alcohol y por el consumo de las personas de su entorno, además de indicadores socioeconómicos y demográficos. Estimamos un modelo probit para la prevalencia mensual de consumo de alcohol, en el marco de la teoría de la adicción racional. Identificamos variables que se asocian con el consumo de alcohol: consumir alcohol en un contexto social y cooperativo, el consumo combinado de alcohol con otras sustancias y el con- sumo de tabaco. La edad de inicio de consumo no es importante para el consumo de alcohol de los hombres, mientras que entre las mujeres existe una relación significativa inversa. Las mujeres presentan mayor probabilidad de beber cuando sus pares lo hacen frecuentemente; el consumo de alcohol entre los hombres es menos probable cuando tienen algún familiar que se emborracha frecuentemente; a mayor riesgo percibido por el consumo individual mayor probabilidad de consumir alcohol y a mayor es el riesgo percibido por el consumo de alcohol de otras personas, menor es la probabilidad de beber. Un mayor nivel de educación del padre se asocia con una mayor probabilidad de consumir alcohol. Estas relaciones no son causales, sin embargo, representan un avance importante en cuanto a la comprensión de la problemática del alcohol en jóvenes universitarios argentinos. Los resultados hallados son útiles para marcar las pautas para profundizar en el desarrollo de modelos explicativos, siendo esta la tarea que sigue luego de haber presentado estos resultados preliminares, con el objetivo final de identificar aspectos cruciales para la elaboración de políticas públicas específicas.
Tácticas usadas en la violencia en el noviazgo en estudiantes universitarios: una revisión integrativa
Authors: Ramírez Chavarría Yerlin , Rodríguez Bonilla Carolina , Guerrero Ramírez Adriana María , Muñoz Rojas Derby
Published: April 2023

Introducción: el fenómeno de la violencia está presente en relaciones de noviazgo; conlleva diversos tipos de manifestaciones y consecuencias, así como distintas formas de ejercerla, presentándose esta de manera directa o indirecta y sutil; por lo que también acarrea múltiples consecuencias en diferentes ámbitos, no solo afectando la integridad de una persona, sino también a nivel de la sociedad en general. Sin embargo, en muchas ocasiones se invisibiliza el fenómeno generando cierta normalización dentro de las relaciones románticas. Objetivo: identificar las tácticas de la violencia en el noviazgo en estudiantes universitarios. Metodología: se realizó una revisión integrativa siguiendo la metodología de Whittemore y Knafl estructurada en etapas, donde se identifica el problema, se realiza una búsqueda de la literatura en bases de datos, tanto en idioma inglés como español; posteriormente, se lleva a cabo una exhaustiva evaluación y de esta se encontraron 21 artículos con enfoques cualitativos y cuantitativos. Finalmente, los documentos fueron evaluados y se realizó una sinopsis. Resultados: los datos recolectados permitieron analizar los resultados para, posteriormente, organizarlos en categorías, etiquetarlos y definirlos de acuerdo con sus características. Las mismas categorías se clasificaron en psicológicas, físicas, sociales y sexuales. Conclusión: existen diversas maneras en las que se ejerce la violencia, van más allá de hechos tangibles o visibles y muchas veces normalizados, lo que puede ocasionar que su detección sea difícil.
Programa de enfermería de autogestión para fortalecer las habilidades de autorregulación en personas trabajadoras
Authors: Ortiz Ramírez Stefany , Hidalgo Araya Mariangel
Published: April 2023

Introducción: las personas pasan gran parte de su tiempo en los lugares de trabajo, por eso son espacios idóneos para la educación en conductas que promuevan la salud. La autogestión corresponde al fenómeno por el cual las personas controlan y son responsables del manejo de los comportamientos en salud. Por su parte, la autorregulación es un proceso integral para comprometerse con estos comportamientos de autogestión. Objetivo: desarrollar un programa de enfermería de autogestión que fortalezca las habilidades de autorregulación en las personas trabajadoras. Metodología: se realizó un reporte de caso grupal virtual utilizando la Teoría de Enfermería de Autogestión Individual y Familiar de Ryan y Sawin, siguiendo las fases de la modalidad de práctica dirigida en conjunto con las etapas del proceso de enfermería, se utilizó la taxonomía NANDA-NOC-NIC. La valoración se realizó a través de un grupo focal y de la aplicación del cuestionario Estilo de Vida II y el Índex de Autorregulación. Se desarrollaron seis sesiones virtuales de una hora cada una. Resultados: los diagnósticos prioritarios que se abordaron en el programa giran en torno a la disposición para mejorar la toma de decisiones, el poder, la resiliencia, la nutrición y el autocuidado, así como el manejo del estrés por sobrecarga y el afrontamiento ineficaz. Conclusión: se observó un fortalecimiento en las habilidades de autorregulación. Dichas habilidades son cruciales para la futura adopción de comportamientos de autogestión que darán como resultado un mejoramiento en la salud integral de las personas trabajadoras.
Programa de telenfermería: utilizando estrategias de afrontamiento al estrés dirigido a personas trabajadoras
Authors: Vargas Gamboa María Alejandra , Nuñez Barboza Enrique
Published: April 2023

Introducción: la salud mental está cobrando más relevancia en los escenarios laborales y, por supuesto, la pandemia por COVID-19. Dentro de las temáticas de la salud mental, el manejo del estrés es una de las que más se debe priorizar, ya que, se puede minimizar el impacto que tienen los estresores sobre las personas trabajadoras, y aquí la teleenfermería funge como una herramienta fundamental para abordar estas problemáticas de una manera segura. Objetivo: desarrollar un programa educativo de teleenfermería para fortalecer el afrontamiento del estrés mediante técnicas de promoción de la salud dirigidas a los trabajadores de una institución de enseñanza. Metodología: para el planeamiento y ejecución del programa educativo, se siguió el proceso de atención de enfermería como eje del aprendizaje. Se valoraron las necesidades utilizando el cuestionario CoPsoQ-istas21 y el Cuestionario de Afrontamiento al Estrés, con lo que se evaluaron los conocimientos previos y los obtenidos al final de la intervención de enfermería. Basados en la información recopilada, se trabajó con el diagnóstico de enfermería Disposición para mejorar el afrontamiento (Código 00158). Resultados: se detallan áreas de desarrollo desde la enfermería en el ambiente laboral, al determinar necesidades en las dimensiones de riesgo psicosocial mayormente afectadas, para así dirigir de manera efectiva un programa educativo. Conclusiones: el afrontamiento al estrés es una temática de gran importancia para la población laboralmente activa, y a través de programas educativos, desde enfermería, se pueden generar conductas promotoras de la salud, que benecien a los trabajadores y a sus familias.
Advances in Oral Cancer Diagnosis: is AI the Magic Tool?
Authors: Chater Amir
Published: April 2023

The application of artificial intelligence (AI) in oral care diagnosis has gained significant momentum in recent years. This review article aims to provide an overview of the latest advances in AI-based techniques for oral care diagnosis, highlighting the methods, challenges, and future directions. The article also discusses the potential of AI in revolutionizing the field of oral care and improving patient outcomes.
Nutritional Imbalance Can Affect the Human Body in Different Ways
Authors: Franjić Siniša
Published: April 2023

An imbalanced nutrition is a common occurrence today. Fast pace, stress, and little time for meal preparation leads to a lack of necessary substances in the body. In the case of an imbalanced nutrition, the body starts giving clear and loud signals. There are certain types of food that contribute to better physical and mental health. Nutritional imbalance can affect the human body in different ways and generate certain health disorders that can become serious and even cause diseases.
Transport permeability of borders
Authors: Tarkhov S.A.
Published: April 2023

The geographic differences in the transport permeability of the borders of 137 countries and 84 administrative-territorial units of the 1st level of the hierarchy of 6 countries are analyzed. It is measured by the indicator K by dividing the border perimeter (km) by the number of transport crossings (entrances) of the border. There are 10 groups of countries of the world according to the size of their territory. According to the peculiarities of the transport and geographical position in relation to the seas and land, all countries are divided into 13 types. The values of the total transport permeability index vary from 6.4 km (Switzerland) to 3391.3 km (Greenland). Its geographic differences in parts of the world are revealed: the countries of Europe on average have K = 52.6 km, the countries of Asia –

145.2 km, Africa – 177.8 km, America – 206.5 km, Australia and Oceania – 271.0 km. 6 subgroups of countries have been identified according to variations in K values: 1) fully open (the most permeable); 2) relatively open (permeable); 3) semi-open (relatively permeable); 4) semi-closed (medium permeable); 5) relatively closed (little permeable); 6) the most closed (almost impermeable). The values of transport permeability of the borders of 18 provinces of China, 20 states of the USA, 36 regions of Russia, 10 lands of Germany, 2 regions of Canada were calculated. The types of correlation between land and sea transport permeability of the borders are revealed.
Functional-time variability of the boundary (case of Kaliningrad oblast borders)
Authors: Gumenyuk L.G.
Published: April 2023

In various geographical approaches to the study of boundaries, one of the main ones is the functional approach, in which it is customary to single out the barrier and contact functions of the boundary. Depending on the balance of these two functions, a certain type of cross-border cooperation is formed and, as a result, the type of border regions. From this point of view, the author proposes to distinguish five theoretical types of border regions. At the same time, this typology can be applied both in the territorial and temporal aspects. Using a comparative geographical and analytical method of research, a functional-temporal typology of the Russian-Polish and Russian-Lithuanian state borders was carried out from the moment of their formation to the present. Time stages were identified, in which a certain balance of the contact and barrier functions of the border was established. The results of the study show that the Russian-Polish border changed the balance of contact and barrier functions more often than the Russian-Lithuanian one, and these changes were multidirectional. The Russian-Lithuanian border changed in one direction, towards the gradual growth of its barrier function.
Potential for settlement developing: concept, subject matter, composition
Authors: Baklanov P.Ya.
Published: April 2023

The idea of a potential for the development of a settlement as its integral property to maintain and increase the level of its socio-economic development, is given. The settlement potential is determined by the level of development of the components of its internal and external structure, their interconnectedness and interdependence. The author defines the permanent components of the internal structure, forming functional blocks like population, social and industrial infrastructure, service sector, as well as natural resource ones, including the territory and components of the natural environment. All these components and their functional blocks are necessary and mandatory for any settlement. The components of the economic sector are required for the settlement, but they are variable and different in distinct settlements. The population consisting of various sex and age groups is the central block. To assess the development potential of a settlement, it is necessary to structure it and weigh the connectivity and interdependence of the components of various blocks, their level of development and elasticity. The second part of the potential is formed by the external structural links of the settlement, which constitute the territorial socio-economic system defined for the central settlement. This system includes all neighboring settlements and nature management structures that are directly tied with the central settlement by a transport network. The generalized schemes of the invariant functional structure of a settlement as well as the estimates of the connectivity and interdependence of the components of various functional blocks are given. Concenters of connectedness and interdependence of blocks directed from the population are distinguished.
Machine Learning Algorithms for Healthcare Sector: A Survey
Authors:   Department of Computer Science and Applications, Khalsa College, Amritsar, India., Kaur Sukhwinder , Arora Mani , Kaur Anureet
Published: April 2023

Machine learning algorithms are used in numerous real- world applications. In Healthcare, Artificial intelligence and machine learning is implemented to improve diagnostic systems. Since the healthcare industry handles a lot of data, including patient information, these large amounts of records are challenging for an individual to keep and analyse. Machine learning systems developed a way around this by automatically identifying patterns and projecting outcomes based on data. Machine learning algorithms can effectively handle the enormous amount of medical data. The rapid growth of machine learning, and big data has facilitated the deployment of machine intelligence algorithms in healthcare applications like precise disease diagnosis, novel methods of treatment, remote healthcare monitoring, drug discovery etc. In this review paper, we review several ML algorithms and their applications in the healthcare sector. Key Word : Machine Learning, Support vector machine, Artificial Neural Network, Decision Tree, Naive Bayes
Climate Change and Food Security
Authors: Datta M , Singh N.P.
Published: April 2023

The book "Climate Change and Greenhouse Gas Emission" in Agriculture presents the principles, practices along with key messages on different relevant issues on climate change and greenhouse gases (GHGs) emissions in agriculture. Chapters also contain probable questions and few solved problems. It is primarily intended for use as text book at undergraduate and postgraduate levels, but it can also be used by researchers of environmental sciences and allied disciplines. The other important feature of the book is that techniques of GHGs measurements at field level with examples are presented which could be useful for practical studies. The book should give students a good foundation in climate change studies and inspire them to take up further studies in the advanced area of environmental sciences.
Diagnosis of severe anaemia and positive antibody screening as consequences of pre-analytical error
Authors: Krygowska-Okrój Marta , Kurpierz Katarzyna , Ćwiklińska Agnieszka
Published: April 2023

The pre-analytical phase is the principal source of errors in laboratory medicine and continues to pose a challenge to laboratory professionals. We present the case of a 73-yearold female patient with a very low hemoglobin level (69 g/L) and positive indirect antiglobulin test result that indicates the key role of phlebotomy as an important error-prone process in which mistakes can have serious consequences for the patient's diagnosis and treatment. We conclude that there is still an urgent and continuous need to provide educational activities for healthcare professionals involved in blood collection, improve blood collection guideline adherence, and eliminate the errors which can affect diagnosis and treatment, thus jeopardising patient safety.
The Continuity Principles of Music Theatre through Mozart's Opera Buffa
Authors:   Art·Design Research Institute of Kyung-Hee University, Lee Eun Hye , Kim Hak Min
Published: April 2023

The purpose of this study is to examine the continuity and separation principles of music theatre and music through Mozart's opera. Mozart wanted to overcome the separation of plays and music that occurs when scripts and music that occur in musical plays are unfolded continuously. Dimensions of have been accepted. Second, the active recitative acampagnato was emphasized with colorful orchestral accompaniment, and this musical effect heightened the dramatic tension by highlighting the lines and emotions. Third, it greatly contributed to the development of the play by emphasizing the characters through arias and duets and depicting important moments and conflicts between characters in the development of the play. This in turn alleviated the clash between music and play, song and script. Finally, through the dramatic use of the ensemble, various events of various characters were woven together to maintain unity in a single musical composition, and through the development of actions through songs, it contributed to resolving the conflict between music and play. The formal songs, recitativo, and dramatic functions of the ensemble that Mozart attempted in the opera are clues that deeply affect the principle of musical songs, which are representative musical theatre today.
The Study on Effect of UX Design on Exercise Motivation of MZ ╶ Focusing on the function of Apple's 'Fitness' app╶
Authors:   Art·Design Research Institute of Kyung-Hee University, Kwon SharonKyuhee , Kim Sun Chul
Published: April 2023

This study aims to study the usability of the exercise motivation function of Apple Watch's exercise application 'Fitness' targeting MZ generation in wearable devices.
The prolinged COVID-19 has increased individual interest in healthcare, which has led to an increase in demand for wearable device that can easily monitor individual health. Wearable devices with the function of recording exercise help users manage their health by inducing exercise in various ways. Accodingly, it is intended to analyze the function of effectively inducing exercise motivation to the MZ generation in wearable devices and present the direction one by one.
A Study on the Direction of the UI Design of Mobile Devices ╶ Focusing on Android’s Minimal App Icon Design╶
Authors:   Art·Design Research Institute of Kyung-Hee University, Park Seo Ryeong , Lee Dong Min
Published: April 2023

Despite the recent development of displays, people's attention is focused on the importance of UI design, and various studies have been conducted, it is difficult to find studies related to the problems of excessive minimalism that currently appear everywhere. Therefore, this study starts with the question of the present time when the design between the app GUI elements lacks differentiation, each individuality disappears, and the boundaries between the elements become ambiguous.
Minimalist UI design has become one of the most important design systems of modern times. Previous scuremorphism designs consumed more pixels than needed for real-life metaphor representation at limited display sizes. This has become a very fatal drawback in small displays such as mobile devices, and it can be seen that a change to a simple design that consumes fewer pixels is inevitable as mobile devices become popular. However, these minimalist designs are being abused and misused, reducing user usability and intuition, and making individuality between each element disappear.
Therefore, in this study, we will look at the design trends and reasons for changes in the UI so far and derive problems with the current UI design, away from ambiguity in the future. After that, we seek the elements that UI design must have to escape from excessive minimalism. Finally, I would like to study the direction in which each element can have differentiation and move toward various design directions.
Determination of genetic fidelity of Micropropagated plants of Zingiber officinale cv-Majhauley of Sikkim Himalaya using RAPD markers
Authors: Sushen Pradhan  , Bharat C. Basistha  , Pratap J. Handique
Published: April 2023

The present investigation was carried out for the determination of genetic conformity of micropropagated plants of Zingiberofficinale cv Majhauley using Random amplified polymorphic DNA (RAPD) technique.Total fifteen different arbitrarydecamers were used as primers to amplify DNA from in vitro plant material to assess the genetic fidelity of 18 months old invitro cultured plantlets. Total 38 amplified reproducible bands were produced from 10 primers with an average of 3.8 perRAPD primer, amplified bands were ranging from 150-950 base pair, the highest seven number of bands found in primerCLT53 (50-875 bp) and lowest one band in CLT 112 (575 bp) and CLT 192 (650 bp) primers. All the primers were found to bemonomorphic and no genetic variation was detected within the micropropagated plants. Present protocol may be used fortesting of ginger propagules to ensure mass production of disease free planting materials
Phytochemical Analysis and Antioxidant potential of Piper species and its Molecular Characterization by RAPD Markers
Authors: Prasad M. P  , Sushant Shekhar  , Babhulkar Amit
Published: April 2023

BACKGROUD & OBJECTIVE: Piper, the pepper plants or pepper vines, are the genus of the Piperaceae family and areimportant economically and ecologically. It contains more than 1,000 species of shrubs, herbs and lianas, many of which arekeystone species in their native habitat. The diversification of this taxon is of interest to understand the evolution of plants. Inthe scope of bioactive compounds, Piper species (P. nigrum, P. retrofractum and P. longum) were screened forphytochemicals. METHODOLOGY: Phytochemical analysis of these plants showed presence of phenolic compounds,anthraquinones, terpenoids, flavinoids and lignin. Also, the methanolic extracts of these plants were tested for their antioxidantpotential by free radical scavenging activity by DPPH assay. All the tested plants showed antioxidant potential and the overallantioxidant activity of P. nigrum was found to be highest. Genomic DNA was extracted from the fresh leaves of selectedcultivars and PCR was performed by using RAPD primers to check the genetic diversity among these cultivars. From the PCRgenerated fingerprint, dendrogram was plotted by cluster analysis of similarity matrix. RESULTS: Dendrogram constructed bycluster analysis of RAPD markers showed that Piper nigrum and Piper retrofractum are closely related. Since morphologicaldifferences among these species are indistinctive, RAPD characterization can be helpful in their Discrimination.CONCLUSION: This finding can be used as prerequisite for plant breeding activities as well as for conservation of geneticresources.
Elucidating the precise interaction of reduced and oxidized states of Neuroglobin with Ubc12 and Cop9 using molecular mechanics studies
Authors: Charu Suri  , Pradeep Kumar Naik
Published: April 2023

BACKGROUD & OBJECTIVE: Neuroglobin is an oxygen binding globin protein highly expressed in neurons. Itis an iron containing heme protein, that exist in both ferrous and ferric form. Recent studies have indicated its role asan endogenous neuroprotective molecule. It is proposed that neuroglobin undergoes post-translational modificationby the process of neddylation and deneddylation. Hence in this study an attempt was made to investigate the modeand mechanism of interaction of ferrous and ferric forms of neuroglobin with Ubc12 and op9, proteins involved inregulation of neddylation and deneddylation respectively, utilizing molecular modelling calculations.METHODOLOGY: In this study, the mode of interactions of Ubc12 and Cop9 with the reduced (Fe2+) and oxidizedstate (Fe3+) of neuroglobin was carried out using ZDock. The top scoring poses for each complex were subjected toenergy minimization using CHARMM Polar H force field in RDock to obtain the binding affinities. RESULTS: Thebinding affinities between of ferrous and ferric forms of neuroglobin with Ubc12 and Cop9 were calculated.CONCLUSION: Results obtained strongly indicate that both Ubc12 and Cop9 interacts with neuroglobin inregulation of neddylation and deneddylation process. Furthermore these results guided us in precisely designingexperiments for biological evaluations.
Analysis Of Microbial Flora In Patients With Chronic Sinusitis Under Going Functional Endoscopic Sinus Surgery (FESS): A Cross-Sectional Study
Authors: Sanam Jindal  , M. Panduranga Kamath
Published: April 2023

BACKGROUND & OBJECTIVE : The purpose of this study is to analyze microbial flora of paranasal sinuses of patientswith chronic sinusitis undergoing functional endoscopic sinus surgery (FESS). METHODOLOGY: This cross sectional studyincludes 60 patients who were diagnosed as chronic sinusitis (male:female ratio is 1:1 mean age: 41 yrs). Computedtomography (CT) imaging of the paranasal sinuses and nasal endoscopic examinations were performed for each patient.Patients were sampled during FESS for microbiological analysis and culture. RESULTS: 56 (93.3%) out of 60 patients werepositive for pathogenic organisms. Staphylococcus aureus and members of the family Enterobacteriaceae were the mostfrequent classical pathogens isolated. Out of the total, 50 patients are positive for aerobic organisms where Staphylococcusaureus was present in 30 (60%), MRSA (Methicillin resistant Staphylococcus aureus) was positive in 8 (16%), followed byStreptococcus isolated in 6 (12%) samples. Other organisms found were Enterobacter 2 (4%), Actimycetes 2 (4%),Acinobacter 2 (4%), Pseudomonas 2 (4%) and Klebsiella 2 (4%). Co-infections with multiple organisms were found in fewpatients. CONCLUSION: The study supports the hypothesis that bacterial infection is the predominant etiology, but not theonly cause of chronic sinusitis. Fungal and allegic etiology was found in few patients in the study. Staphylococcus aureus ismost commonly isolated organism in patients with chronic sinusitis.
The Prediction of Nanoscale Drug Molecular Structure and Acid Dissociation Constants of 5-Fluorouracil in Aqueous Solution Using DFT Methods
Authors: Fardad Koohyar  , Farhoush Kiani  , Mehran Abbaszadeh  , Mohammad Pousti  , Seyed Mohammad Seyed Baghery  , Hassan Godarzi
Published: April 2023

Background and Objective : In this work, dissociation of nano drug 5-Fluorouracil derivatives was studied theoretically.Methodology : For this purpose, Gibbs free energy values for neutral and deprotonated forms of 5-Fluorouracil were calculated atgas and aqueous phases by using density functional theory (DFT) method. Solvent effects are taken into account by means ofpolarizable continuum model (PCM). Result : It was shown that, theoretically calculated pKa values are in good agreement withthe existing experimental pKa values, which are determined from capillary electrophoresis, potentiometric titration and UV–visiblespectrophotometric measurements. Conclusion : In summary, cluster continuum method with implicit-explicit solvent moleculeswas used for calculation of pKa values. Total energies and molecular parameters were obtained for 5-FUra nanoscale drug systems,at B3LYP/6-31G(d) level of theory for the anion, cation, and neutral species.
Flow Modeling in a Porous Cylinder with Regressing Walls Using Semi Analytical Approach
Authors: Mohammadreza Azimi  , Ali Montazeri Hedesh  , Saeed Karimian
Published: April 2023

In this paper, the mathematical modeling of the flow in a porous cylinder with a focus on applications to solid rocketmotors is presented. As usual, the cylindrical propellant grain of a solid rocket motor is modeled as a long tube withone end closed at the headwall, while the other remains open. The cylindrical wall is assumed to be permeable so asto simulate the propellant burning and normal gas injection. At first, the problem description and formulation areconsidered. The Navier-Stokes equations for the viscous flow in a porous cylinder with regressing walls are reducedto a nonlinear ODE by using a similarity transformation in time and space. Application of Differential TransformationMethod (DTM) as an approximate analytical method has been successfully applied. Finally the results have beenpresented for various cases.
Study of Heavy metal uptake by Bacillus sp and E. coli
Authors: Chandrareddy Vijayadeep  , Pothukuchi Subrahmanya Sastry  , Marigowda Jayaramu
Published: April 2023

Background: Over the past century, unrestricted mining, extensive industrialization, modern agricultural practices and faultywaste disposal methods have resulted in the release of unprecedented levels of toxic heavy metals like Cd, Hg, Ag, Sn, Pb, Cu, Co,Mn, Zn, etc into the environment. Many metals are essential for microbial growth in less concentration, yet are toxic in higherconcentrations. Various methods are available for the removal and management of heavy metals: Conventional physico-chemicalmethods and emerging biosorption methods. Biosorption is an attractive alternative approach which involves the binding oradsorption of heavy metals to living or dead cells. Many microbes have the ability to selectively accumulate metals. Aim: Thepresent study was intended to analyze the uptake systems of Bacillus and E. coli against different concentration of heavy metalslike Zn, Cu, Cd, and Hg in their salt form incorporated into nutrient broth medium observed over a regular interval of time.Methodology: Analysis was based on how much of the metal from the original concentration used was left behind in the mediaafter the rest being up taken by the organism. This was done using Atomic Absorption Spectrophotometry (AAS) which wasindirectly the representation of percent uptake of heavy metal by the respective organism. Results: The study showed that Gram –ve organisms like E.coli exhibited more resistance to metals like Zn, Cu and Hg in relative comparison with Gram +ve organismslike Bacillus. Conclusion: Bacillus sps was less sensitive to effect of Cd than in E. coli
Floristic composition and ecological assessment of tree species diversity in tropical forests of Srikakulam and Vizianagaram districts of Andhra Pradesh, India
Authors: Duvvada Srinivasa Rao  , Prayaga Murty Pragad  , Owk Aniel Kumar
Published: April 2023

Background and Aim: Phytosociological investigation of vegetation serves as a pre-requisite for investigating the details of theprimary productivity of an ecosystem. The present study deals with Environmental Statistics and Ecological Assessment of treespecies diversity in Srikakulam and Vizianagaram districts of Andhra Pradesh, India. Methods: The present investigation dealswith the comparison of species diversity indices of plant species i.e., Simpson’s index, Shannon –wiener index, species richnesswith other counter parts. Importance Value Index = Relative density + Relative frequency + Relative dominance Based on thefrequency classes of tree species were determined. According to Raunkiaer classify to There are 5 frequency classes, i.e. 'A' classwith the species of frequency ranging from 1-20%; 'B' class 21- 40%; 'C' class 41-60%; 'D' class 61-80% and 'E' class 81- 100%based on the frequency pattern of the community, the homogeneity and heterogeneity of the vegetation. Results: The studyresulted in documentation of total 165 tree species, belonging to 119 genera and 50 families were recorded, and 160 are dicots and5 are monocots. The ecological studies have taken up to visualize the positive impact of protection on tree diversity. Conclusion:An understanding of the distribution of tree species and their assemblages must play an important role in elucidating the largerpatterns of distribution of diversity. The quantitative inventory of tree species diversity revealed a considerable variation in thecomposition of dominant species and density in various forest areas and the estimations of IVI have helped to understanding theecological significance of the species, present in different communities.
Evaluation of biodiesel production from microalgae collected from fresh water habitat
Authors: Sudip Shah  , Prakash Lokesh
Published: April 2023

Background: Algae are the fastest growing in the world. About 50% of their weight is oil. This lipid can be used to makebiodiesel for cars, trucks and airplanes. Algae will someday be competitive as a source of biofuel. Continuous use of petroleumsourced fuels is now widely recognized as unsustainable because of depleting supplies and the contribution of these fuels to theaccumulation of carbondioxide. Methodology: In this study, we tried to evaluate the physico-chemical properties of algal oil. Anaturally occurring algal sample was collected from Kommaghatta lake, Bangalore. Algae were identified as Spirogyra sps. Oilwas extracted from the dried algal samples using chloroform: methanol as a solvent system. Fatty acid analysis was done in IndianInstitute of Horticultural Research, Bangalore. Physico-chemical properties of algal oil such as density, lipid content, pH wereestimated. Results: Gas chromatographic analysis revealed higher percentage of methyl palmitate, methyl oleate, methyl linoleate.The physico-chemical properties of algal oil meet the properties of the standard fuel. Conclusion: It is concluded that the algal oilcan be used as a potential biofuel.
Abordaje de la dispepsia con Helicobacter pylori como causa
Authors: Durazo Mendez Esarely , Navarro Gastelum Dalia Lizbeth
Published: April 2023

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Lo invisible del maltrato infantil: ¿Puede modificar la expresión génica?
Authors: Hinojosa Pérez Botswana , Flores Díaz Andrea
Published: April 2023

El maltrato infantil es un problema de salud pública e incluye todos los tipos de maltrato, físico o psicológico, abuso sexual, desatención, negligencia y explotación comercial o de otro tipo que causen o puedan causar un daño a la salud, desarrollo o dignidad del niño. Los niños víctimas de maltrato presentan mayor riesgo de depresión, ansiedad, trastorno bipolar, síndrome de estrés postraumático, diabetes mellitus, hipertensión arterial, enfisema, enfermedad pulmonar obstructiva crónica, bronquitis crónica, migrañas, lumbalgia, problemas de visión, accidente cerebrovascular, neoplasias, tabaquismo, obesidad, desnutrición, síndrome de fatiga crónica en la edad adulta, artritis, enfermedad intestinal y otras enfermedades autoinmunes. Esto puede ser explicado en parte por alteraciones moleculares principalmente epigenéticas, específicamente por metilación en el ADN. La principal alteración molecular encontrada fue la metilación asociada a los genes relacionados con el eje hipotálamo-pituitaria-adrenal, vías de neurotransmisores, del sistema inmunológico, así como el acortamiento de los telómeros. En conclusión, se debe de trabajar en crear conciencia y, en consecuencia, estrategias específicas para respetar los derechos de los niños. La información disponible fue consultada mediante una búsqueda bibliográfica en español e inglés en las bases de datos PubMed, INEGI, Google Scholar y revistas como Lancet y Nature hasta el 7 de enero de 2022. Las palabras claves que se utilizaron para la búsqueda por separado y combinadas fueron “Violencia”, “epigenética”, “metilación”, “violencia intrafamiliar”, “abuso infantil”, “ADN”, “trastorno” “maltrato”.
Editorial
Authors: Alzúa Pichardo Eduardo
Published: April 2023

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Evaluación de la química hepática alterada
Authors: Mayon Flores Briana Arely
Published: April 2023

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Trastornos de la motilidad esofágica
Authors: Vazquez Medina Oswaldo Humberto
Published: April 2023

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Reposición de electrolitos y soluciones intravenosas: sodio
Authors: Ledesma-López Lorena , Silva-Rivera Maria Monserrath
Published: April 2023

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La casa-fábrica de obrar azulejos de Vicente Pedrón y Josefa María Casavall en València (1686-1778)
Authors: GONZALEZ TERUEL MERCEDES , GONZÁLEZ TERUEL MERCEDES
Published: April 2023

Las fábricas de azulejos en la ciudad de València del último cuarto del siglo XVII y principio del XVIII elaboraron una producción singular. La continuidad técnica facilitó la evolución estética consiguiendo colores y diseños innovadores de alto nivel cromático. Las noticias sobre la actividad de estos obradores, sus creaciones, y sus autores, no son abundantes y más cuando muchos edificios de la época en estudio repletos de azulejos, han ido desapareciendo con el tiempo. En esta ocasión, recurrimos a la información que proporcionan algunos pleitos generados en el entorno de dichas fábricas con el objetivo de identificar las características de las obras realizadas y los productos que generó la actividad cerámica en un segmento temporal, amenudo ignorado.
Joaquín Sorolla, ideólogo del museo de arte de Alicante. Historia y fortuna crítica de un proyecto para una ciudad
Authors: Sánchez Izquierdo Pablo
Published: April 2023

En 1919, el Ayuntamiento de Alicante, en reunión plenaria, admitió una propuesta través de la cual se exponía la idea de Joaquín Sorolla de crear un museo de arte para la ciudad. El proyecto, que fue acogido con gran entusiasmo, atravesó diferentes avatares que dificultaron su inauguración provocando el desánimo en la sociedad. Aun así, el pueblo alicantino no desistió en su empeño hasta pocos meses antes de la Guerra Civil y, gracias a distintas fuentes de archivos y hemerotecas, es posible reconstruir la historia y la fortuna crítica de esta iniciativa.
Artistas, marchantes y connoisseurs. Subasta del atrezo de Fortuny en Roma
Authors: Roca Cabrera María
Published: April 2023

El pintor Mariano Fortuny Marsal (1838-1874), reunió una magnífica colección de artes aplicadas que, tras su repentina muerte, fue subastada en Roma y París. En este articulo nos centraremos en desvelar los detalles de la venta romana, un acontecimiento que generó gran interés debido a la envergadura y singularidad del conjunto. El estudio exhaustivo de un catálogo de la subasta manuscrito con el nombre de los compradores y la transcripción de los lotes de atrezo adquiridos, nos permitirá realizar diversas aportaciones: identificación de las figuras de los compradores, el papel que desempeñaron en la red del coleccionismo decimonónico o su repercusión en la obra de algunos de estos artistas.
La fortuna “imperial” de las escaleras dobles en la España del siglo XVIII
Authors: Fernández-Santos Ortiz-Iribas Jorge Pablo , Walliser Martín María Luisa
Published: April 2023

La ingeniosa utilización de escaleras dobles en la España del siglo XVIII se remontaba a tres tipologías básicas desarrolladas a lo largo del siglo XVI para los alcázares regios de Madrid (B1) y Toledo (C1) y para el monasterio de El Escorial (D1). Este artículo se fija en sus derivaciones (denominadas B2, C2, D2, etcétera), deteniéndose en los ejemplos más espectaculares. Criterios formales como el orden y la simetría interactuaban con requisitos funcionales (acceso lateral o axial y flujo circulatorio o emplazamiento estratégico dentro del edificio) conformándose a su vez con nociones de decoro que, especialmente en lo tocante a la arquitectura civil, dependían del rango del comitente. La floración de magnificentes y a veces arriesgadas escaleras en la Andalucía barroca merece reconsiderarse. Tras 1734 la nueva dinastía borbónica promovió oficialmente el estilo áulico internacional del abate Filippo Juvarra. Su aprendiz, Ventura Rodríguez, diseñó escaleras dobles enraizadas en tipologías tradicionales e imbuidas de un sofisticado cosmopolitismo romano. Arquitectos como Juan Pedro Arnal, Ignacio Haan y Manuel Tolsà siguieron sus pasos con un depurado refinamiento neoclásico aliado a usos creativos de tipos legados por la tradición.
El pes de la tradició en la classificació verbal del català
Authors: Lloret Maria-Rosa
Published: April 2023

L’existència de submodels de conjugació amb increments a tots els dialectes i conjugacions del català, així com el nombre migrat de verbs que presenten, en conjunt, les conjugacions ii (batre, témer, poder, dir) i iiia (dormir), fan pensar que tan lícit és proposar subconjugacions regulars de flexió amb increments (velars i palatals), possibles a totes les conjugacions (en línia amb la proposta inicial de Viaplana 1984), com ho és limitar la flexió regular als únics patrons que són realment productius, això és, a la conjugació i (cantar) i, a molta distància, la conjugació iiib (servir) (en línia amb les observacions de Ferrater 1970). No sembla, en canvi, eficaç, ni per qüestions numèriques ni per motius dialectals, mantenir els models de conjugació regular proposats per la gramàtica tradicional (i: cantar; ii: batre o témer; iiia: dormir, iiib: servir). Amb aquests precedents, l’objectiu del present treball és, d’una banda, repassar els motius tradicionals i dialectològics que sostenen encara la classificació verbal habitual i, de l’altra, repensar els models de conjugació regular, tot considerant qüestions pràctiques relacionades amb l’ensenyament de la llengua.
L’acusatiu preposicional en català: d’on venim i cap a on anem?
Authors: Pineda Anna
Published: April 2023

En aquest treball analitzem l’acusatiu preposicional del català tant des del punt de vista de l’evolució diacrònica del fenomen com des de la perspectiva de l’abast que presenta en el conjunt dels dialectes catalans avui dia. Primer, a partir d’un exhaustiu estudi de corpus de la llengua antiga hem constatat que el fenomen ja existia en la llengua medieval (amb pronoms personals, noms propis i SN), de manera que, en aquest sentit, pot considerar-se un fenomen genuí. Ara bé, les dades diacròniques indiquen també diàfanament que a partir del segle XVI, quan la influència de l’espanyol esdevé una realitat cada cop més severa, el percentatge d’ús de la preposició a davant de CD augmenta exponencialment.
Si bé a inicis del segle XX la publicació de la normativa fabriana significà un abans i un després en l’aparició del fenomen en els textos escrits formals, el fet és que la comunitat catalanòfona no s’ha arribat a desprendre mai d’aquest recurs morfosintàctic, ans al contrari. Així ho confirmem a bastament a partir d’un estudi a gran escala sobre l’abast del fenomen en el conjunt dels dialectes catalans, basat en entrevistes individuals amb vora 400 parlants, que fan tasques tant de producció d’oracions com d’emissió de judicis de gramaticalitat.