bluuebunny/crossref_metadata_2025 huggingface dataset:
Forearm Endothelial Response in Smokeless Tobacco Users Compared with Cigarette Smokers and Nonusers of Tobacco
Authors: Granberry Mark C. , Smith Eugene S. , Troillett Rhonda D. , Eidt John F.
Published: May 2004

Study Objective. To compare brachial artery flow‐mediated dilation (FMD) in subjects who use smokeless tobacco, smoke cigarettes, or do not use any tobacco product.

Design. Cross‐sectional study.

Setting. University‐affiliated outpatient clinic.

Subjects. Seventeen apparently healthy volunteers who for more than 1 year smoked at least 10 cigarettes/day, used at least two containers of smokeless tobacco/week, or did not use any tobacco product.

Measurements and Main Results. Baseline characteristics of subjects were similar among the three groups except for mean age and serum cotinine level. Baseline brachial artery diameter, endothelium‐dependent FMD induced by reactive hyperemia, and endothelium‐independent dilation induced by administration of sublingual nitroglycerin were measured. Mean FMD over baseline was 4.1% ± 0.7% in subjects who used smokeless tobacco, 3.9% ± 5.1% in cigarettes smokers, and 12.2% ± 5.7% in nonusers of tobacco (p=0.01). Endothelium‐independent dilation induced by nitroglycerin was not statistically different among the three groups.

Conclusion. Brachial artery FMD, a surrogate for endothelial dysfunction, was significantly impaired in smokeless tobacco users and cigarette smokers compared with nonusers of tobacco.
Pharmacokinetics of Meropenem 0.5 and 2 g Every 8 Hours as a 3‐Hour Infusion
Authors: Dandekar Prachi K. , Maglio Dana , Sutherland Christina A. , Nightingale Charles H. , Nicolau David P.
Published: May 2004

Study Objective. To assess the pharmacokinetics of meropenem administered as a 3‐hour infusion.

Design. Randomized, crossover, open‐label study.

Setting. Clinical research center.

Subjects. Six healthy adult male volunteers.

Intervention. Each subject received meropenem 0.5 or 2 g every 8 hours as a 3‐hour infusion for three doses and then crossed over to the other dosage regimen.

Measurement and Main Results. Pharmacokinetic parameters of both regimens were compared, and no significant differences between 0.5‐ and 2‐g doses for the dose‐independent parameters (half‐life, clearance, and volume of distribution at steady state) were observed. The regimens displayed dose proportionality and were consistent with that of a traditional 0.5‐hour infusion. The 3‐hour infusion optimized the pharmacodynamic profile of meropenem and worked within the constraints of stability at room temperature stability.

Conclusion. Prolonging the percentage of time above the minimum inhibitory concentration is a feasible option with meropenem; however, further studies are needed to quantify how this increase translates to efficacy.
Compound heterozygous mutations of cytochrome P450 oxidoreductase gene (POR) in two patients with Antley–Bixler syndrome
Authors: Adachi Masanori , Tachibana Katsuhiko , Asakura Yumi , Yamamoto Toshiyuki , Hanaki Keiichi , Oka Akira
Published: May 2004

Antley–Bixler syndrome (ABS) is characterized by skeletal defects including craniosynostosis and radiohumeral synostosis. Although mutations in the FGFR2 gene have been found in some patients called ABS, genetic heterogeneity of this syndrome has been proposed. We have previously reported three ABS patients with unique abnormalities in steroidogenesis (apparent decreased activity of 17α‐hydroxylase, 17,20‐lyase, and 21‐hydroxylase). Decreased activity of lanosterol 14α‐demethylase has also been described in an ABS patient. Since all these enzymes require cytochrome P450 oxidoreductase (encoded by POR) as an electron donor, we studied POR in two unrelated ABS patients with abnormal steroidogenesis. Direct sequencing of POR revealed that both patients had compound heterozygous mutations (1329insC and R454H in a male patient, 1698insC and R454H in a female patient). The two insertional mutations were assumed to generate truncated and unstable mRNAs. The R454H mutation was assumed to be deleterious because the R454 resides in the FAD‐binding domain and is highly conserved among diverse species. Our results demonstrate that mutations in POR cause the ABS phenotype with autosomal recessive inheritance and with characteristic abnormalities in steroidogenesis. © 2004 Wiley‐Liss, Inc.
Validation of urinary cortisol as an indicator of hypothalamic‐pituitary‐adrenal function in the bearded emperor tamarin (Saguinus imperator subgrisescens)
Authors: McCallister Josephine M. , Smith Tessa E. , Elwood Robert W.
Published: May 2004

The use of cortisol levels as a measure of stress is often complicated by the use of invasive techniques that may increase hypothalamic‐pituitary‐adrenal (HPA) axis activity during sample collection. The goal of this study was to collect samples noninvasively and validate an enzyme‐immunoassay (EIA) for the measurement of cortisol in urine to quantify HPA axis activity in the bearded emperor tamarin (Saguinus imperator subgrisescens). Urine samples were collected from trained subjects between 0700 and 0730 hr during a 1‐month period, and were pooled for immunological validation. We validated the assay immunologically by demonstrating specificity, accuracy, precision, and sensitivity. For biological validation of the assay, we showed that levels of urinary cortisol (in samples collected between 0700 and 1700 hr) varied significantly across the day. Cortisol concentration was lowest at 0700 hr, increased to a mid‐morning peak (0900 hr), and declined across the remainder of the day in a typical mammalian circadian pattern. We thus demonstrate that urinary cortisol can be used to quantify HPA activity in S.i. subgrisescens. Am. J. Primatol. 63:17‐23, 2004. © 2004 Wiley‐Liss, Inc.
Test of revised method of age estimation from the auricular surface of the ilium
Authors: Mulhern Dawn M. , Jones Erica B.
Published: May 2004

The objective of this paper is to test a revised method of age estimation based on the morphology of the auricular surface recently proposed by Buckberry and Chamberlain ([2002] Am. J. Phys. Anthropol. 119:231–239). The study sample consists of 309 individuals of known sex, age, and race from the Terry and Huntington Collections. Auricular surfaces were scored using the revised technique to determine whether it is equally applicable to both sexes as well as blacks and whites. The auricular surfaces of the same individuals were also scored using the original method of auricular surface scoring developed by Lovejoy et al. ([1985] Am. J. Phys. Anthropol. 68:15–28) to determine whether the revised technique is comparable to the original method in terms of accuracy. Results show that the revised method is equally applicable to males and females as well as blacks and whites. The revised method is less accurate than the original method for individuals between 20–49 years of age, but more accurate for individuals between 50–69 years of age. Am J Phys Anthropol, 2004. © 2004 Wiley‐Liss, Inc.
Possible influence of BCHE locus of butyrylcholinesterase on stature and body mass index
Authors: Souza Ricardo L.R. , Fadel‐Picheth Cyntia , Allebrandt Karla V. , Furtado Lupe , Chautard‐Freire‐Maia Eleidi A.
Published: May 2004

Butyrylcholinesterase activity has been shown to be positively associated with weight and body mass index (BMI). The present study was carried out to search for an association between variants of the BCHE gene and weight, stature, and BMI on the basis of means and variances compared between nonusual variants and their respective usual controls. Individuals bearing the atypical mutation (N = 52) did not differ from their usual phenotype controls (N = 104) in these parameters. The BCHE*U/BCHE*K individuals (N = 222) presented a significantly higher BMI variance than their BCHE*U/BCHE*U controls (N = 222, F = 1.40, P = 0.012). This higher BMI variance does not seem to be an isolated effect of the K mutation, but appears to be the result of an interaction between the K allele and the usual allele, since no such difference in variance was detected between BCHE*K/BCHE*K individuals (N = 23) and their BCHE*U/BCHE*U (N = 23) controls. These data may suggest a relation between variability in the BCHE locus itself and BMI. Individuals with the BCHE UF phenotype (N = 45) showed a significantly higher mean stature (about 3 cm more; P = 0.02) than their controls with the usual phenotype (N = 135). A role in cell proliferation has been proposed for BCHE, and since growth depends on the number of mitoses, it is not unexpected that variants of this enzyme may influence body stature in different ways. This study reports the first data on the relation of BCHE alleles to anthropometric characters. Am J Phys Anthropol, 2004. © 2004 Wiley‐Liss, Inc.
Mechanical significance of femoral head trabecular bone structure inLorisandGalagoevaluated using micromechanical finite element models
Authors: Ryan Timothy M. , van Rietbergen Bert
Published: May 2004

Work on the interspecific and intraspecific variation of trabecular bone in the proximal femur of primates demonstrates important architectural variation between animals with different locomotor behaviors. This variation is thought to be related to the processes of bone adaptation whereby bone structure is optimized to the mechanical environment. Micromechanical finite element models were created for the proximal femur of the leapingGalago senegalensisand the climbing and quadrupedalLoris tardigradusby converting bone voxels from high‐resolution X‐ray computed tomography scans of the femoral head to eight‐noded brick elements. The resulting models had approximately 1.8 million elements each. Loading conditions representing takeoff phase of a leap and more generalized load orientations were applied to the models, and the models were solved using the iterative “row‐by‐row” matrix‐vector multiplication algorithm. The principal strain and Von Mises stress results for the leaping model were similar for both species at each load orientation. Similar hip joint reaction forces in the range of 4.9 × to 12 × body weight were calculated for both species under each loading condition, but the hip reaction values estimated forLoriswere higher than predicted based on locomotor behavior. These results suggest that functional adaptation to hip joint loading may not fully explain the differences in femoral head trabecular bone structure inGalagoandLoris. The finite element method represents a unique and useful tool for analyzing the functional adaptation of trabecular bone in a diversity of animals and for reconstructing locomotor behavior in extinct taxa. Am J Phys Anthropol, 2004. © 2004 Wiley‐Liss, Inc.
Chemisch katalysierte asymmetrische Cyanhydrinsynthesen
Authors: Brunel Jean‐Michel , Holmes Ian P.
Published: May 2004

In den letzten 20 Jahren wurden bemerkenswerte Fortschritte bei der Entwicklung chemisch katalysierter asymmetrischer Cyanhydrinsynthesen erzielt. Klassische, meist stöchiometrische Syntheseverfahren mit hoher Substratspezifität sind durch eine neue Generation von Katalysatoren revolutioniert worden. Die heute verfügbaren Methoden konkurrieren mit enzymatischen Verfahren und übertreffen diese in vielen Fällen hinsichtlich Anwendungsbreite und Enantioselektivität. Insbesondere in der Synthese von biologisch wichtigen Naturstoffen und therapeutisch relevanten synthetischen Verbindungen finden chemisch katalysierte asymmetrische Cyanhydrinsynthesen vermehrt Anwendung.
Chemically Catalyzed Asymmetric Cyanohydrin Syntheses
Authors: Brunel Jean‐Michel , Holmes Ian P.
Published: May 2004

Over the past two decades, significant advances have been made towards developing chemically catalyzed asymmetric cyanohydrin syntheses. Preparations that were classically highly substrate specific, often using stoichiometric quantities of reagents, have been revolutionized by a new generation of catalysts. Methods currently available rival, and in many cases surpass, enzymatic procedures in terms of synthetic utility, generic applicability, and enantioselectivity. Such protocols are increasingly finding application in the syntheses of both biologically active natural products and therapeutically important synthetic compounds.
The influence of waterlogging and variations in pedology and ignition upon resultant susceptibilities: a series of laboratory reconstructions
Authors: Weston D. G.
Published: May 2004

Magnetic survey techniques, such as fluxgate gradiometry, depend greatly on bodies of soil developing enhanced magnetic susceptibilities. Coarse mineral soils, especially those subject to a high groundwater table, often fail to develop enhanced susceptibilities and gradiometry. An example of this is Easingwold, in the Vale of York, UK. Gradiometry detected very little, however, subsequent excavation uncovered a complex of features suggesting multiphase activity and evidence for industry. This non‐detection is attributed to the coarse mineral soils and the high watertable. Several laboratory reconstructions were made to investigate the influence of specific characteristics of soil and ignition episode upon susceptibility. It was found that variations in soil texture had marked impacts on the levels of susceptibility attained, as did waterlogging. Leaching had a limited effect upon soil magnetic susceptibility, but there was variation according to texture. Copyright © 2004 John Wiley & Sons, Ltd.
A new parametric model for the assessment and calibration of medium‐range ensemble temperature forecasts
Authors: Jewson Stephen , Brix Anders , Ziehmann Christine
Published: May 2004

We present a new method for the assessment and calibration of medium‐range ensemble temperature forecasts. The method is based on maximizing the likelihood of a simple parametric model for the temperature distribution, and leads to some new insights into the predictability of uncertainty. Copyright © 2004 Royal Meteorological Society
Theoretical Search for Very Short Metal—Actinide Bonds: NUIr and Isoelectronic Systems.
Authors: Gagliardi Laura , Pyykkoe Pekka
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Charge Transfer in the Electron Donor—Acceptor Complex BH3NH3
Authors: Mo Yirong , Song Lingchun , Wu Wei , Zhang Qianer
Published: May 2004

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Ternary Rare Earth Metal Silicides Ln2Ln′3Si4 with Orthorhombic Sm5Ge4 or Tetragonal Zr5Si4 Type Structure.
Authors: Rodewald Ute Ch. , Heying Birgit , Johrendt Dirk , Hoffmann Rolf‐Dieter , Poettgen Rainer
Published: May 2004

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Synthesis and Structural Relationship of the Ternary Indides Sc3Ni2.10(5)In3.60(5), Sc3Ni2.14(2)In3.76(2), ScPd0.981(2)In and Sc3Rh1.594(9)In4.
Authors: Lukachuk Mar'yana , Zaremba Vasyl' I. , Hoffmann Rolf‐Dieter , Poettgen Rainer
Published: May 2004

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X‐Ray Absorption Spectroscopy Study of Cu0.25V2O5 and Zn0.25V2O5 Aerogel‐Like Cathodes for Lithium Batteries.
Authors: Frabetti Elisa , Deluga Gregg A. , Smyrl William H. , Giorgetti Marco , Berrettoni Mario
Published: May 2004

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Temperature Dependent X‐Ray Diffraction Study on Gd5Sn4 Compound.
Authors: Yang H. F. , Rao G. H. , Liu G. Y. , Ouyang Z. W. , Liu W. F. , Feng X. M. , Chu W. G. , Liang J. K.
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Crystal Structure of Rhombohedral λ‐AlFeSi.
Authors: Sugiyama Kazumasa , Kaji Nobutaka , Hiraga Kenji
Published: May 2004

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Calcium and Strontium Hexaluminates: NMR Evidence that “Pentacoordinate” Cation Sites Are Four‐Coordinated.
Authors: Du Lin‐Shu , Stebbins Jonathan F.
Published: May 2004

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Synthesis and Magnetic Properties of Single‐Crystals of MnFe2O4 Nanorods.
Authors: Wang Jun , Chen Qianwang , Hou Binyang , Peng Zhenmeng
Published: May 2004

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Exchange‐Coupled Soft Magnetic FeNi—SiO2 Nanocomposite.
Authors: Zhao Yuwen , Ni Chaoying , Kruczynski David , Zhang Xiaokai , Xiao John Q.
Published: May 2004

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A Magnetic Study of USn2‐xGex Alloys
Authors: Manfrinetti P. , Palenzona A. , Dhar S. K. , Kulkarni R.
Published: May 2004

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Investigation of the Al—Pd—Fe Phase Diagram Between 50 and 100 at.% Al: Ternary Phases.
Authors: Balanetskyy S. , Grushko B. , Velikanova T. Ya. , Urban K.
Published: May 2004

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The Solid‐State Lanthanoid‐Assisted Hydrolysis of the Solvolytically “Inert” [AsF6]‐ Ion.
Authors: Ponikvar Maja , Sedej Borka , Liebman Joel F.
Published: May 2004

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Flashing Carbon on Cold Surfaces.
Authors: Wakabayashi Tomonari , Ong Aik‐Loong , Strelnikov Dmitry , Kraetschmer Wolfgang
Published: May 2004

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Low‐Temperature Cluster Catalysis.
Authors: Judai Ken , Abbet Stephane , Woerz Anke S. , Heiz Ulrich , Henry Claude R.
Published: May 2004

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Simple Hydrothermal Synthesis of Nanostructured and Nanorod Zn—Al Complex Oxides as Novel Nanocatalysts.
Authors: Shen Shoucang , Hidajat Kus , Yu Liya E. , Kawi Sibudjing
Published: May 2004

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High‐Pressure Synthesis, Crystal Structure, and Properties of the New Orthorhombic Rare‐Earth meta‐Oxoborates Ln(BO2)3 (Ln: Dy—Lu).
Authors: Emme Holger , Nikelski Tanja , Schleid Thomas , Poettgen Rainer , Moeller Manfred Heinrich , Huppertz Hubert
Published: May 2004

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Crystal Structure, Polymorphism, and Properties of the New Vanadyl Phosphate Na4VO(PO4)2.
Authors: Panin Rodion V. , Shpanchenko Roman V. , Mironov Andrei V. , Velikodny Yuri A. , Antipov Evgeny V. , Hadermann Joke , Tarnopolsky Vasily A. , Yaroslavtsev Andrei B. , Kaul Enrique E. , Geibel Christoph
Published: May 2004

For Abstract see ChemInform Abstract in Full Text.
Efficient Asymmetric Transfer Hydrogenation of Activated Olefins Catalyzed by Ruthenium Amido Complexes.
Authors: Chen Ying‐Chun , Xue Dong , Deng Jin‐Gen , Cui Xin , Zhu Jin , Jiang Yao‐Zhong
Published: May 2004

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Catalytic Asymmetric Carbohydroxylation of Alkenes by a Tandem Diboration/Suzuki Cross‐Coupling/Oxidation Reaction.
Authors: Miller Steven P. , Morgan Jeremy B. , Nepveux Felix J. V , Morken James P.
Published: May 2004

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Asymmetric Hydrocyanation of Hydrazones Catalyzed by Lanthanide‐PYBOX Complexes.
Authors: Keith John M. , Jacobsen Eric N.
Published: May 2004

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Application of Phosphinous Amide Ligands in Palladium Complex‐Catalyzed Asymmetric Allylic Alkylation: Influence of Steric Effects on Enantioselectivity.
Authors: Chen Xuanhua , Guo Rongwei , Li Yueming , Chen Gang , Yeung Chi‐Hung , Chan Albert S. C.
Published: May 2004

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C2‐Symmetric Chiral Bis(thiazoline) and Bis(oxazoline) Ligands and Their Application in the Catalytic Asymmetric Allylic Alkylation.
Authors: Fu Bin , Du Da‐Ming , Xia Qing
Published: May 2004

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Construction of Arene‐Fused‐Piperidine Motifs by Asymmetric Addition of 2‐Trityloxymethylaryllithiums to Nitroalkenes: The Asymmetric Synthesis of a Dopamine D1 Full Agonist, A‐86929.
Authors: Yamashita Mitsuaki , Yamada Ken‐ichi , Tomioka Kiyoshi
Published: May 2004

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Unusual Reversal of Regioselectivity in Antibody‐Mediated Aldol Additions with Unsymmetrical Methyl Ketones.
Authors: Maggiotti V. , Bahmanyar S. , Reiter M. , Resmini M. , Houk K. N. , Gouverneur V.
Published: May 2004

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Preparation Asymmetric Reduction of Ketones in a Biphasic Medium with an (S)‐Alcohol Dehydrogenase under in situ‐Cofactor‐Recycling with a Formate Dehydrogenase.
Authors: Groeger Harald , Hummel Werner , Rollmann Claudia , Chamouleau Francoise , Huesken Hendrik , Werner Helge , Wunderlich Christine , Abokitse Kofi , Drauz Karlheinz , Buchholz Stefan
Published: May 2004

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Novel Vanadium‐Catalyzed Oxidation of Alcohols to Aldehydes and Ketones under Atmospheric Oxygen.
Authors: Velusamy Subbarayan , Punniyamurthy T.
Published: May 2004

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A Sulfoxide‐Promoted, Catalytic Method for the Regioselective Synthesis of Allylic Acetates from Monosubstituted Olefins via C—H Oxidation.
Authors: Chen Mark S. , White M. Christina
Published: May 2004

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Fluorous Osmium Tetraoxide (FOsO4): A Recoverable and Reusable Catalyst for Dihydroxylation of Olefins.
Authors: Huang Yangen , Meng Wei‐Dong , Qing Feng‐Ling
Published: May 2004

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A Mild, Efficient and Environmentally Friendly Method for the Regio‐ and Chemoselective Synthesis of Enaminones Using Bi(TFA)3 as a Reusable Catalyst in Aqueous Media.
Authors: Khosropour Ahmad R. , Khodaei Mohammad M. , Kookhazadeh Mehdi
Published: May 2004

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Mild and Efficient Silylcyanation of Ketones Catalyzed by N‐Methylmorpholine N‐Oxide.
Authors: Kim Sung Soo , Kim Dong Won , Rajagopal Gurusamy
Published: May 2004

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Use of Diamines Containing the α‐Phenylethyl Group as Chiral Ligands in the Asymmetric Hydrosilylation of Prochiral Ketones.
Authors: Mastranzo Virginia M. , Quintero Leticia , Anaya de Parrodi Cecilia , Juaristi Eusebio , Walsh Patrick J.
Published: May 2004

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Arylation of Heterocycles via Rhodium‐Catalyzed C—H Bond Functionalization.
Authors: Lewis Jared C. , Wiedemann Sean H. , Bergman Robert G. , Ellman Jonathan A.
Published: May 2004

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A 1,3‐Lithium Shift of Propargylic/Allenylic Lithium and the Subsequent Transmetalation Coupling Reaction with Aryl Halides.
Authors: Ma Shengming , He Qiwen
Published: May 2004

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Suzuki Cross‐Couplings of Unactivated Secondary Alkyl Bromides and Iodides.
Authors: Zhou Jianrong , Fu Gregory C.
Published: May 2004

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Highly Active Trialkoxymolybdenum(VI) Alkylidyne Catalysts Synthesized by a Reductive Recycle Strategy.
Authors: Zhang Wei , Kraft Stefan , Moore Jeffrey S.
Published: May 2004

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A Convenient Protocol for the Esterification of Carboxylic Acids with Alcohols in the Presence of di‐t‐Butyl Dicarbonate.
Authors: Goossen Lukas J. , Doehring Arno
Published: May 2004

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Synthesis and Protection of Aryl Sulfates Using the 2,2,2‐Trichloroethyl Moiety.
Authors: Liu Yong , Lien I‐Feh Felicia , Ruttgaizer Scott , Dove Peter , Taylor Scott D.
Published: May 2004

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Highly Substituted Pyrrolidinones and Pyridones by 4‐CR/2‐CR Sequence.
Authors: Beck Barbara , Picard Anne , Herdtweck Eberhardt , Doemling Alexander
Published: May 2004

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Silyl Group Deprotection by Pd/C/H2. A Facile and Selective Method.
Authors: Kim Seongjin , Jacobo Sheila Marie , Chang Chih‐Tsung , Bellone Sophie , Powell William S. , Rokach Joshua
Published: May 2004

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First Carbamates Conversion to Amides by Simple Alkyl Group Transfer from Trialkylalanes.
Authors: El Kaim Laurent , Grimaud Laurence , Lee Anabelle , Perroux Yannick , Tirla Cornelia
Published: May 2004

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Expanded Chemistry of Formamidine Ureas.
Authors: Diaz David D. , Finn M. G.
Published: May 2004

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Diastereoselective Electrochemical Carboxylation of Chiral α‐Bromocarboxylic Acid Derivatives: An Easy Access to Unsymmetrical Alkylmalonic Ester Derivatives.
Authors: Feroci Marta , Orsini Monica , Palombi Laura , Sotgiu Giovanni , Colapietro Marcello , Inesi Achille
Published: May 2004

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Stereoselective Syntheses of the Methyl Esters of (E)‐ and (Z)‐2‐Methyl‐6‐oxohept‐2‐enoic Acid.
Authors: Banwell Martin G. , Jury Jasmine C.
Published: May 2004

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Oxidation of Thiols with Dinitrogen Tetroxide.
Authors: Kramer Thomas , Roeder Thorsten
Published: May 2004

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Copper‐Mediated Synthesis of N‐Acyl Vinylogous Carbamic Acids and Derivatives: Synthesis of the Antibiotic CJ‐15,801.
Authors: Han Chong , Shen Ruichao , Su Shun , Porco John A. Jr.
Published: May 2004

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Samarium Diiodide Mediated 6‐exo Cyclizations of Methylenecyclopropyl Ketones.
Authors: Underwood Jonathan J. , Hollingworth Gregory J. , Horton Peter N. , Hursthouse Michael B. , Kilburn Jeremy D.
Published: May 2004

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Transition‐Metal‐Catalyzed Formation of trans Alkenes via Coupling of Aldehydes.
Authors: Zhu Shifa , Liao Yuanxi , Zhu Shizheng
Published: May 2004

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4‐Substituted Anilides as Selective Melatonin MT2 Receptor Agonists.
Authors: Epperson James R. , Deskus Jeffrey A. , Gentile Anthony J. , Iben Lawrence G. , Ryan Elaine , Sarbin Nathan S.
Published: May 2004

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New Chiral Bis(oxazoline) Rh(I)‐, Ir(I)‐ and Ru(II)‐Complexes for Asymmetric Transfer Hydrogenations of Ketones.
Authors: Debono Nathalie , Besson Michele , Pinel Catherine , Djakovitch Laurent
Published: May 2004

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Allylation of Aldehydes, Aldimines and Ring Opening of Terminal Aromatic Epoxides by Scandium Triflate Using Polyethylene Glycol (PEG) as an Efficient Recyclable Medium.
Authors: Choudary Boyapati M. , Jyothi Karangula , Madhi Sateesh , Kantam Mannepalli L.
Published: May 2004

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Facile O‐Arylation of Phenols and Carboxylic Acids.
Authors: Liu Zhijian , Larock Richard C.
Published: May 2004

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An Ionic Liquid Based on a Cyclic Guanidinium Cation is an Efficient Medium for the Selective Oxidation of Benzyl Alcohols.
Authors: Xie Haibo , Zhang Suobo , Duan Haifeng
Published: May 2004

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Environmentally Friendly and Efficient Process for the Preparation of β‐Hydroxyl Ketones.
Authors: Wang Guan‐Wu , Zhang Ze , Dong Ya‐Wei
Published: May 2004

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Evaluation of Loxoprofen and Its Alcohol Metabolites for Potency and Selectivity of Inhibition of Cyclooxygenase‐2.
Authors: Riendeau Denis , Salem Myriam , Styhler Angela , Ouellet Marc , Mancini Joseph A. , Li Chun Sing
Published: May 2004

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Inhibition of Estrone Sulfatase (ES) by Alkyl and Cycloalkyl Ester Derivatives of 4‐[(Aminosulfonyl)oxy] Benzoic Acid.
Authors: Patel Chirag K. , Owen Caroline P. , Ahmed Sabbir
Published: May 2004

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Novel Arylsulfonamides Possessing Sub‐Picomolar HIV Protease Activities and Potent anti‐HIV Activity against Wild‐Type and Drug‐Resistant Viral Strains.
Authors: Miller John F. , Furfine Eric S. , Hanlon Mary H. , Hazen Richard J. , Ray John A. , Robinson Laurence , Samano Vicente , Spaltenstein Andrew
Published: May 2004

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Direct Synthesis of Sulfonamides and Activated Sulfonate Esters from Sulfonic Acids.
Authors: Caddick Stephen , Wilden Jonathan D. , Judd Duncan B.
Published: May 2004

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Inhibition of α‐Chymotrypsin with Thiol‐Bearing Substrate Analogues in the Presence of Zinc Ion.
Authors: Han Min Su , Oh Dong Ju , Kim Dong H.
Published: May 2004

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Cu(II)‐Catalyzed Enantioselective Aldol Condensation Between Malonic Acid Hemithioesters and Aldehydes.
Authors: Orlandi Simonetta , Benaglia Maurizio , Cozzi Franco
Published: May 2004

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A Selective, Convenient, and Efficient Conversion of Sulfides to Sulfoxides.
Authors: Xu Wei Liang , Li Yun Zheng , Zhang Qing Shan , Zhu He Sun
Published: May 2004

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Synthesis and Antifungal Activities of Phenylenedithioureas.
Authors: Phuong Truong , Khac‐Minh Thai , Ha Nguyen Thi Van , Phuong Huynh Thi Ngoc
Published: May 2004

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A Novel Class of Amide‐Derived Air‐Stable P,O‐Ligands for Suzuki Cross‐Coupling at Low Catalyst Loading.
Authors: Dai Wei‐Min , Li Yannain , Zhang Ye , Lai Kwong Wah , Wu Jinlong
Published: May 2004

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Facile Synthesis of Symmetrical Functionalized Biaryls from Aryl Halides Catalyzed by Commercial Zinc Dust Using Ammonium Formate.
Authors: Abiraj K. , Srinivasa G. R. , Gowda D. Channe
Published: May 2004

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Synthesis of 1,1‐Diarylethylenes from an α‐Stannyl β‐Silylstyrene.
Authors: Belema Makonen , Nguyen Van N. , Zusi F. Christopher
Published: May 2004

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Decarbonylative Heck Olefination of Enol Esters: Salt‐Free and Environmentally Friendly Access to Vinyl Arenes.
Authors: Goossen Lukas J. , Paetzold Jens
Published: May 2004

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Synthesis of 1‐Indanones by Intramolecular Friedel—Crafts Reaction of 3‐Arylpropionic Acids Catalyzed by Tb(OTf)3.
Authors: Cui Dong‐Mei , Zhang Chen , Kawamura Masato , Shimada Shigeru
Published: May 2004

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Synthesis and Antitumor Activity of 10‐Substituted Benzylidene Anthrone.
Authors: Hu Weixiao , Zhou Wei
Published: May 2004

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Evidence for the in situ Formation of Copper Acetylides During Pd/Cu Catalyzed Synthesis of Enynes: A New Synthesis of Allenynols.
Authors: Bertus Philippe , Fecourt Fabien , Bauder Claude , Pale Patrick
Published: May 2004

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A Readily Synthesized and Highly Active Epoxide Carbonylation Catalyst Based on a Chromium Porphyrin Framework: Expanding the Range of Available β‐Lactones.
Authors: Schmidt Joseph A. R. , Mahadevan Viswanath , Getzler Yutan D. Y. L. , Coates Geoffrey W.
Published: May 2004

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The Mechanism of Nucleophilic Substitution of 1‐Alkyl‐2‐(tosyloxymethyl)aziridines.
Authors: D'hooghe Matthias , De Kimpe Norbert
Published: May 2004

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A Concise Route to 2‐Amino‐2‐aryl‐3H‐benzofurans and Their Use as Precursors to 3‐Aryl‐3H‐benzofuran‐2‐one and 1H‐Benzofuro[2,3‐b]pyridin‐2‐one Derivatives
Authors: Gerster Michele , Wicki Reto
Published: May 2004

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Discovery of Thiophene‐2‐carboxylic Acids as Potent Inhibitors of HCV NS5B Polymerase and HCV Subgenomic RNA Replication. Part 1. Sulfonamides.
Authors: Chan Laval , et al. et al.
Published: May 2004

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Microwave‐Assisted Paal—Knorr Reaction. A Rapid Approach to Substituted Pyrroles and Furans.
Authors: Minetto Giacomo , Raveglia Luca F. , Taddei Maurizio
Published: May 2004

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A General Synthesis of Substituted Indoles from Cyclic Enol Ethers and Enol Lactones.
Authors: Campos Kevin R. , Woo Jacqueline C. S. , Lee Sandra , Tillyer Richard D.
Published: May 2004

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Facile Preparation of 2,3‐Disubstituted Indole Derivatives Through Low‐Valent Titanium Induced Intramolecular Reductive Coupling Reactions of Acylamido‐Carbonyl Compounds.
Authors: Fan Xuesen , Zhang Xinying
Published: May 2004

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Synthesis of Cyclopenta[b]indol‐1‐ones and Carbazol‐4‐ones from N‐(2‐Halophenyl)‐Substituted Enaminones by Intramolecular Heck Reaction.
Authors: Soerensen Ulrik S. , Pombo‐Villar Esteban
Published: May 2004

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3‐Trifluoromethyl‐4‐nitro‐5‐arylpyrazoles Are Novel KATP Channel Agonists.
Authors: Peat Andrew J. , Townsend Claire , McKay M. Craig , Garrido Dulce , Terry Christopher M. , Wilson Jayme L. R. , Thomson Stephen A.
Published: May 2004

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Facile Synthesis of 3‐Trimethylsilylindazoles by [3 + 2]Cycloaddition Reaction of Lithium Trimethylsilyldiazomethane with Benzynes.
Authors: Shoji Yoshimichi , Hari Yoshiyuki , Aoyama Toyohiko
Published: May 2004

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N‐[1‐Aryl‐2‐(1‐imidazolo)ethyl]‐guanidine Derivatives as Potent Inhibitors of the Bovine Mitochondrial F1F0 ATP Hydrolase.
Authors: Atwal Karnail S. , et al. et al.
Published: May 2004

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5H‐Oxazol‐4‐ones as Building Blocks for Asymmetric Synthesis of α‐Hydroxycarboxylic Acid Derivatives.
Authors: Trost Barry M. , Dogra Kalindi , Franzini Maurizio
Published: May 2004

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Synthesis and SAR Evaluation of 1,2,4‐Triazoles as A2A Receptor Antagonists.
Authors: Alanine Alexander , Anselm Lilli , Steward Lucinda , Thomi Stefan , Vifian Walter , Groaning Michael D.
Published: May 2004

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Synthesis of Optically Active α,β‐Unsaturated Triazolyl Alcohols via Chiral Auxiliary‐Modified NaBH4 Reduction of the Corresponding Ketones.
Authors: Zhou Zhenghong , Tang Yilong , Wang Lixin , Zhao Guofeng , Zhou Qilin , Tang Chuchi
Published: May 2004

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Oxidative Cyclization of β‐Hydroxyenones with Palladium(II): A Novel Entry to 2,3‐Dihydro‐4H‐pyran‐4‐ones.
Authors: Reiter Maud , Ropp Sandrine , Gouverneur Veronique
Published: May 2004

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Synthesis and Biological Evaluation of Novel Coumarin Derivatives with a 7‐Azomethine Linkage.
Authors: Kontogiorgis Christos A. , Hadjipavlou‐Litina Dimitra J.
Published: May 2004

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Microwave‐Induced in situ Wittig Reaction of Salicylaldehydes with Ethyl Chloroacetate and Triphenylphosphine in Solventless System.
Authors: Valizadeh H. , Shockravi A. , Heravi M. M. , Ghadim H. Abbasi
Published: May 2004

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Thiazoles and Thiopyridines: Novel Series of High Affinity h5HT7 Ligands.
Authors: Thomson Christopher G. , Beer Margaret S. , Curtis Neil R. , Diggle Helen J. , Handford Emma , Kulagowski Janusz J.
Published: May 2004

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An Easy Preparation of Pyridinium N‐Heteroarylaminides.
Authors: Reyes M. Jose , Burgos Carolina , Izquierdo M. Luisa , Alvarez‐Builla Julio
Published: May 2004

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Direct Vinylogous Mannich‐Type Reactions via Ring Opening and Rearrangement of Vinyloxiranes.
Authors: Lautens Mark , Tayama Eiji , Nguyen Duy
Published: May 2004

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New Reactivity of Hydroxyallylpyridyl Derivatives as C‐3 Carbon Nucleophiles.
Authors: Giomi Donatella , Piacenti Michela , Brandi Alberto
Published: May 2004

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Synthesis and Antimicrobial Activity of the Dithiocarbamates of Anabasine, Piperidine and Morpholine.
Authors: Baikenova G. G. , Abdulina G. A. , Gazaliev A. M. , Fazylov S. D. , Kudaibergenova S. Zh.
Published: May 2004

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Synthesis of New Terpyridines under Solventless Conditions Using Alumina.
Authors: Husson Jerome , Migianu Evelyne , Beley Marc , Kirsch Gilbert
Published: May 2004

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Subtype Selective NMDA Receptor Antagonists: Evaluation of Some Novel Alkynyl Analogues.
Authors: Kornberg Brian E. , Nikam Sham S. , Wright Jon L. , Kesten Suzanne R. , Meltzer Leonard T. , Coughenour Linda , Barr Bridget , Serpa Kevin A. , McCormick Julie
Published: May 2004

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A Novel Class of Apical Sodium‐Dependent Bile Acid Transporter Inhibitors: The Amphiphilic 4‐Oxo‐1‐phenyl‐1,4‐dihydroquinoline Derivatives.
Authors: Kurata Hitoshi , Suzuki Sayaka , Ohhata Yasuo , Ikeda Takuya , Hasegawa Toru , Kitayama Ken , Inaba Toshimori , Kono Keita , Kohama Takafumi
Published: May 2004

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Fluorinated Dihydroquinolines as Potent n‐NOS Inhibitors.
Authors: Jaroch Stefan , Rehwinkel Hartmut , Hoelscher Peter , Suelzle Detlev , Burton Gerardine , Hillmann Margit , McDonald Fiona M. , Miklautz Heribert
Published: May 2004

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Synthesis of Polysubstituted 4,5,6,7‐Tetrahydrofuro[2,3‐c]pyridines by a Novel Multicomponent Reaction.
Authors: Fayol Aude , Zhu Jieping
Published: May 2004

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An Efficient One‐Pot Synthesis of Annulated Pyridines Utilizing a Directed ortho‐Metalation/Transmetalation Approach.
Authors: Davies Antony J. , Brands Karel M. J. , Cowden Cameron J. , Dolling Ulf‐H. , Lieberman David R.
Published: May 2004

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Discovery and in vitro Evaluation of Potent TrkA Kinase Inhibitors: Oxindole and Aza‐Oxindoles.
Authors: Wood Edgar R. , Kuyper Lee , Petrov Kimberly G. , Hunter Robert N. III , Harris Philip A. , Lackey Karen
Published: May 2004

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An Elegant Synthetic Route to 3‐Cyano‐5,6‐dihydro‐2‐ethoxy‐4‐phenyl‐pyrido[2,3‐a]carbazoles.
Authors: Danish Isravel A. , Prasad Karnam J. R.
Published: May 2004

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Synthesis of Carbazoles by a Balanced Four Component Condensation.
Authors: Cochard Fabien , Laronze Marie , Sigaut Philippe , Sapi Janos , Laronze Jean‐Yves
Published: May 2004

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Cycloadditions of o‐Quinone Dimethides with p‐Quinol Derivatives: Regiocontrolled Formation of Anthracyclic Ring Systems.
Authors: Wang Junhua , Pettus Liping H. , Pettus Thomas R. R.
Published: May 2004

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A Novel Cu‐Catalyzed Three‐Component One‐Pot Synthesis of Dihydropyrimidin‐2(1H)‐ones Using Microwaves under Solvent‐Free Conditions.
Authors: Gohain Mukut , Prajapati Dipak , Sandhu Jagir S.
Published: May 2004

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Efficient One‐Pot Synthesis of 2‐Oxo‐1,9a‐dihydro‐2H‐pyrido[1,2‐a]pyrimidine Derivatives.
Authors: Adib Mehdi , Yavari Hossine , Mollahosseini Mehdi
Published: May 2004

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Facile Route to 3,5‐Disubstituted Morpholines: Enantioselective Synthesis of O‐Protected trans‐3,5‐Bis(hydroxymethyl)morpholines.
Authors: Dave Rajesh , Sasaki N. Andre
Published: May 2004

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Benzodiazepine‐Based Selective Inhibitors of Mitochondrial F1F0 ATP Hydrolase.
Authors: Hamann Lawrence G. , Ding Charles Z. , Miller Arthur V. , Madsen Cort S. , Wang Paulina , Stein Philip D. , Pudzianowski Andrew T. , Green David W. , Monshizadegan Hossain , Atwal Karnail S.
Published: May 2004

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1,3‐Dipolar Cycloadditions of Azomethine Ylides to Alkenylboronic Esters. Access to Substituted Boron Analogues of β‐Proline and 3‐Hydroxypyrrolidines.
Authors: Belfaitah Ali , Isly Muriel , Carboni Bertrand
Published: May 2004

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Direct Electrophilic Silylation of Terminal Alkynes.
Authors: Andreev Aleksey A. , Konshin Valeri V. , Komarov Nikolai V. , Rubin Michael , Brouwer Chad , Gevorgyan Vladimir
Published: May 2004

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The Development of Potent Non‐Peptidic PTP‐1B Inhibitors.
Authors: Dufresne Claude , et al. et al.
Published: May 2004

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(2,7‐Disubstituted‐1,8‐biphenylenedioxy)bis(dimethylaluminum) as Bidentate Organoaluminum Lewis Acids: Elucidation and Synthetic Utility of the Double Electrophilic Activation Phenomenon.
Authors: Ooi Takashi , Takahashi Makoto , Yamada Masao , Tayama Eiji , Omoto Kiyoyuki , Maruoka Keiji
Published: May 2004

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C—H Bond Activation of Hydrocarbons by an Imidozirconocene Complex.
Authors: Hoyt Helen M. , Michael Forrest E. , Bergman Robert G.
Published: May 2004

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A Novel Metabolite from the Hybrid Soft Coral Sinularia maxima x Sinularia polydactyla: A Biosynthetically Mixed Skeleton Linking Cembrane and Africanane Terpenoids.
Authors: Kamel Haidy Nasr , Fronczek Frank R. , Fischer Nikolaus H. , Slattery Marc
Published: May 2004

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Rapid Assembly of Polycyclic Substances by a Multicomponent Cascade [4 + 2]—[2 + 2] Cycloadditions: Total Synthesis of the Proposed Structure of Paesslerin A.
Authors: Inanaga Kazato , Takasu Kiyosei , Ihara Masataka
Published: May 2004

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Total Synthesis of (.+‐.)‐Herbertenolide by Stereospecific Formation of Vicinal Quaternary Centers in a Crystalline Ketone.
Authors: Ng Danny , Yang Zhe , Garcia‐Garibay Miguel A.
Published: May 2004

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Bile Acid Amides Derived from Chiral Amino Alcohols: Novel Antimicrobials and Antifungals.
Authors: Hazra Braja G. , Pore Vandana S. , Dey Sanjeev Kumar , Datta Suchitra , Darokar Mahendra P. , Saikia Dharmendra , Khanuja S. P. S. , Thakur Anup P.
Published: May 2004

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Design of Small Molecule Ketoamide‐Based Inhibitors of Cathepsin K.
Authors: Catalano John G. , Deaton David N. , Long Stacey T. , McFadyen Robert B. , Miller Larry R. , Payne J. Alan , Wells‐Knecht Kevin J. , Wright Lois L.
Published: May 2004

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Lysyl 4‐Aminobenzoic Acid Derivatives as Potent Small Molecule Mimetics of Plasminogen Kringle 5.
Authors: Sheppard George S. , Kawai Megumi , Craig Richard A. , Davidson Donald J. , Majest Sandra M. , Bell Randy L. , Henkin Jack
Published: May 2004

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Asymmetric Synthesis of N‐Protected Amino Acids by the Addition of Organolithium Carboxyl Synthons to ROPHy/SOPHy‐Derived Aldoximes and Ketoximes.
Authors: Cooper Tracey S. , Laurent Pierre , Moody Christopher J. , Takle Andrew K.
Published: May 2004

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Concise and Stereocontrolled Syntheses of Phosphonate C‐Glycoside Analogues of β‐D‐ManNAc and β‐D‐GlcNAc 1‐O‐Phosphates.
Authors: Wen Xianghui , Hultin Philip G.
Published: May 2004

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Synthesis of C1‐Alkyl‐ and Acylglycals from Glycals Using a B‐Alkyl Suzuki—Miyaura Cross Coupling Approach.
Authors: Potuzak Justin S. , Tan Derek S.
Published: May 2004

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Thioglycosynthases: Double Mutant Glycosidases that Serve as Scaffolds for Thioglycoside Synthesis.
Authors: Jahn Michael , Chen Hongming , Muellegger Johannes , Marles Jennifer , Warren R. Antony J. , Withers Stephen G.
Published: May 2004

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Stereoselective Palladium‐Catalyzed O‐Glycosylation Using Glycals.
Authors: Kim Hahn , Men Hongbin , Lee Chulbom
Published: May 2004

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Sc(OTf)3 as Efficient Catalyst for Aryl C‐Glycoside Synthesis.
Authors: Ben Akimi , Yamauchi Takahito , Matsumoto Takashi , Suzuki Keisuke
Published: May 2004

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The Caulindoles: Dimeric Prenylindoles from Isolona cauliflora.
Authors: Makangara John J. , Henry Leonia , Jonker Stephan A. , Nkunya Mayunga H. H.
Published: May 2004

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Synthesis of Barettin.
Authors: Johnson Ann‐Louise , Bergman Jan , Sjoegren Martin , Bohlin Lars
Published: May 2004

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Deacetylation of 2′‐O‐Ts‐3′,5′‐Di‐O‐acetylpurine Nucleosides via a Free Radical Reaction.
Authors: Liu Qi‐Bin , Feng Feng , Qu Gui‐Rong
Published: May 2004

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Rational Design of Azepane‐Glycoside Antibiotics Targeting the Bacterial Ribosome.
Authors: Hermann Thomas , et al. et al.
Published: May 2004

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First Synthesis of (.+‐.)‐Bis‐homosarkomycin Ethyl Ester.
Authors: Samarat Ali , Landais Yannick , Amri Hassen
Published: May 2004

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First Synthesis of Antimalarial Machaeriols A and B.
Authors: Chittiboyina Amar G. , Reddy Ch. Raji , Watkins E. Blake , Avery Mitchell A.
Published: May 2004

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Synthesis of Embellished Bicyclo[2.2.2]octenones and a Sigmatropic 1,2‐Acyl Shift in an Excited State: A Novel and Stereoselective Route to (.+‐.)‐Hirsutic Acid C and Complicatic Acid.
Authors: Singh Vishwakarma , Tosh Dilip K. , Mobin Shaikh M.
Published: May 2004

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Furanaphin: A Novel Naphtho[2,3‐c]furan‐4(1H)‐one Derivative from the Aphid Aphis spiraecola Patch.
Authors: Horikawa Mitsuyo , Noguchi Tadashi , Takaoka Shigeru , Kawase Masaki , Sato Masao , Tsunoda Tetsuto
Published: May 2004

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Hydroamination of Olefin in a Special Conjugated Spiroketal Enol Ether System, Diastereoselective Synthesis of Amino‐Containing Tonghaosu Analogues.
Authors: Yin Biao‐Lin , Hu Tai‐Shan , Wu Yu‐Lin
Published: May 2004

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Synthesis and Evaluation of Novel Bacterial rRNA‐Binding Benzimidazoles by Mass Spectrometry.
Authors: He Yun , et al. et al.
Published: May 2004

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Synthesis and Biological Evaluation of Piperazine‐Based Derivatives as Inhibitors of Plasminogen Activator Inhibitor‐1 (PAI‐1).
Authors: Ye Bin , et al. et al.
Published: May 2004

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Synthesis of Potassium Niobiate (KNbO3) Thin Films by Low‐Temperature Hydrothermal Epitaxy.
Authors: Suchanek Wojciech L.
Published: May 2004

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Pt Hollow Nanospheres: Facile Synthesis and Enhanced Electrocatalysts.
Authors: Liang Han‐Pu , Zhang Hui‐Min , Hu Jin‐Song , Guo Yu‐Guo , Wan Li‐Jun , Bai Chun‐Li
Published: May 2004

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The Design and Synthesis of Sulfonamides as Caspase‐1 Inhibitors.
Authors: Harter William G. , Albrecht Hans , Brady Kenneth , Caprathe Bradley , Dunbar James , Gilmore John , Hays Sheryl , Kostlan Catherine R. , Lunney Beth , Walker Nigel
Published: May 2004

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Synthesis of New Thiophene and Benzo[b]thiophene Hydrazide Derivatives as Human NPY Y5 Antagonists.
Authors: Galiano Silvia , Erviti Oihana , Perez Silvia , Moreno Antonio , Juanenea Laura , Aldana Ignacio , Monge Antonio
Published: May 2004

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Synthesis and Characterization of Phosphors for Flat‐Panel Displays
Authors: Rohwer Lauren E. Shea , Walko Robert J.
Published: May 2004

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Paradigms and Paradoxes: The Solubility of AgCl in Water: Some Thermochemical Issues of Aqueous Ag+ Ion
Authors: Liebman Joel F.
Published: May 2004

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Magnesium Manganese Oxide Nanoribbons: Synthesis, Characterization, and Catalytic Application
Authors: Saratovsky Ian , Hagerman Michael
Published: May 2004

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