bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Psychological and Physical Aggression In Relationship Reconciliation
Authors: Dailey René M. , Hazlett Abigail D. , Brass-Rosenfield Chelsea
Published: January 2022

Previous research has established a link between aggression and relationship cycling (i.e., multiple breakups and renewals with the same romantic partner). Couples who have experienced breakups and renewals are up to twice as likely to have experienced psychological and physical aggression in their relationships. Partners who return to previous relationships are also more susceptible to greater violence. To explore this link further, we employed longitudinal data from 179 individuals who had recently experienced a breakup. We assessed post-dissolution closeness and self-concept clarity as mediators of the association between a history of aggression while dating and reconciliation within 6 months. We also assessed the directional nature of aggression (unidirectional or bidirectional) as a potential moderator. Logistic regressions as well as moderating mediating analyses (using Hayes’ PROCESS) showed that both psychological and physical aggression were linked to reconciliation. Additionally, closeness mediated this association, but only for those who reported undirectional aggression. Specifically, aggression prior to breakups was associated with feeling closer with the ex-partner, which set the stage for reconciliation, primarily for those who reported one-sided aggression in their relationships. The findings offer insights on identifying those who are more susceptible to revictimization as well as why partners return to previously aggressive relationships. The results suggest additional research examining the causal linkages between cycling and aggression is warranted.
“People don’t come in Asking for the Gospel, They come in for a Pregnancy Test!” Feminizing Evangelism in Crisis Pregnancy Centers
Authors: Hutchens Kendra
Published: January 2022

Led by women, faith-based pregnancy centers constitute the largest segment of the movement to oppose abortion in the United States. These centers provide services for women (e.g., options counseling and ultrasounds) but face criticism for offering assistance motivated and shaped by conservative religious views. In this article, I explore how evangelical staff at two faith-based centers in the western United States conceptualize their work as religious practice and reimagine “doing” evangelism. I draw upon observational, interview, and textual data to show how gender shapes the definition, expression, and affective nature of evangelism. In “feminizing evangelism,” the centers challenge established evangelical practice to “share the gospel,” which necessitates spiritual regulation, a distinct form of emotional labor. In highlighting the emotional complexity of gendering religious practices, this article contributes to scholarly conversations at the intersection of gender, religion, and emotion.
Simulation of flow-field and debris temperature analysis in micro-electrical discharge milling using slotted tools
Authors: Mullya Satish , Karthikeyan Ganesh , Ganachari Vaibhav
Published: January 2022

In micro-electrical discharge milling (μED-milling), the rotation and forward feed motion of the tool is the key element responsible for evacuation of the debris particles. The inability to eliminate debris from the interelectrode gap (IEG) causes secondary discharge, short-circuit, and hampers removal rate. This problem is predominant in electrical discharge machining (EDM) where the tool is stationary. Various methods have been devised in the literature to boost debris removal from the IEG. In this paper, the use of a slotted tool with different cross-sections is proposed. The dielectric flow-field, debris trajectory, and cooling rate are calculated using computational fluid dynamics (CFD). Effect of different parameters such as tool rotation, gap size, jet velocity, the shape of slots on the dielectric flow is determined. The slots on the tool create turbulence which enhances the debris removal from the IEG. It also provides the space to accumulate the debris particles, thereby increasing the removal rate. The variation in the dielectric flow-field greatly affects the debris flushing from the IEG. The trajectory of the debris particles depends on their initial position in the IEG and they cool rapidly, which is validated using simulation and mathematical approach.
Prejudice in “inclusive” spaces: Cisgenderist collusion in the interview context
Authors: Knott-Fayle Gabriel , Peel Elizabeth , Witcomb Gemma L.
Published: January 2022

Feminist reflexivity aims to (re)consider and challenge power differentials that exist in the research process. This activity is well represented in, for example, research into heterosexism. In this article we expand feminist reflexive practice in relation to cisgenderism through a (re)examination of interview transcripts conducted by a cisgender researcher on the topic of cisgenderism in media representations of trans and intersex sportspeople. Drawing on interviews with 18 cisgender and trans and non-binary participants, we analyse three forms of researcher collusion in cisgenderism, namely: 1) perpetuating cisgenderism in the selection of media materials; 2) assuming trans women are the referent; and 3) disunifying assumptions about trans sportspeople. This reflexive analysis is discussed with regard to how analytical insights can be generated into the operation and functioning of prejudice. In so doing, we further the conception of prejudice as a ubiquitous and latent activity in research practices.
Effects of real-ambient PM2.5 exposure plus lipopolysaccharide on multiple organ damage in mice
Authors: Chen Wenqi , Chen Shanshan , Zhao Lifang , Zhang Mei , Geng Hong , Dong Chuan , Li Ruijin
Published: January 2022

Background: The toxicological effects of fine particulate matter (PM2.5) on the cardiopulmonary and nervous systems have been studied widely, whereas the study of PM2.5 on systemic toxicity is not in-depth enough. Lipopolysaccharide (LPS) can cause multiple organ damage. The combined effects of co-exposure of PM2.5 plus LPS on the stomach, spleen, intestine, and kidney are still unclear. Purpose: This study was aimed to explore the toxicological effects of co-exposure of PM2.5 and LPS on the different organs of mice. Research Design and Study Sample Using a real-ambient PM2.5 exposure system and an intraperitoneal LPS injection mouse model, we investigated multiple organ damage effects on male BALB/c mice after co-exposure of PM2.5 plus LPS for 23 weeks in Linfen, a city with a high PM2.5 concentration in China. Data Collection: Eosin-hematoxylin staining, ELISA and the biochemical assay analysed the toxicological effects. Results: The pathological tissue injury on the four organs above appeared in mice co-exposed to PM2.5 plus LPS, accompanied by the body weight and stomach organ coefficient abnormality, and significant elevation of pro-inflammatory cytokines levels, oxidative stress in the spleen and kidney, and levels of kidney injury molecule (KIM-1) increase in the kidney. There were tissue differences in the pathological damage and toxicological effects on mice after co-exposure, in which the spleen and kidney were more sensitive to pollutants. In the PM2.5 + LPS group, the superoxide dismutase inhibition and catalase (CAT) activity promotion in the kidney or spleen of mice were significant relative to the PM2.5 group; the CAT and interleukin-6 (IL-6) levels in the spleen were raised considerably compared with the LPS group. Conclusions: These findings suggested the severity and sensitivity of multiple organ injuries in mice in response to PM2.5 plus LPS.
Cytochrome P450 3A5 polymorphism affects the metabolism of sorafenib and its toxicity for hepatocellular carcinoma cells in vitro
Authors: Song Hong-yan , Xia Jing-sheng , Chen Yong-gang , Chen Ling
Published: January 2022

Objective

Cytochrome P450 3A5 ( CYP3A5) is a highly polymorphic gene and the encoded protein variants differ in catalytic activity, leading to inter-individual variation in metabolic ability. The aim of the current study was to investigate the effects of seven allelic variants on the ability of CYP3A5 to metabolize sorafenib in vitro and further explore the impacts of CYP3A5 polymorphism on the proliferation and apoptosis of hepatocellular carcinoma cell line (HepG2) induced by sorafenib.

Methods

Wild-type and variant CYP3A5 enzymes were expressed in Spodoptera frugiperda insect cells using a baculovirus dual-expression system, and protein expression was checked by western blot. The enzymes were incubated with sorafenib at 37°C for 30 min, and formation of the major metabolite sorafenib N-oxide was assayed using ultra-performance liquid chromatography and tandem mass spectrometry. Intrinsic clearance values (V max/ K m) were calculated for each enzyme. Additionally, recombinant HepG2 cells transfecting with CYP3A5 variants were used to investigate the effects of sorafenib on the proliferation of HepG2 cells.

Results

Intrinsic clearance of the six variants CYP3A5*2, CYP3A5*3A, CYP3A5*3C, CYP3A5*4, CYP3A5*5, and CYP3A5*7 was 26.41–71.04% of the wild-type ( CYP3A5*1) value. In contrast, the clearance value of the variant CYP3A5*6 was significantly higher (174.74%). Additionally, the decreased ATP levels and cell viability and the increased cell apoptosis in HepG2 cells transfected with CYP3A5*2, CYP3A5*3A, CYP3A5*3C, CYP3A5*4, CYP3A5*5, and CYP3A5*7 were observed, whereas, the increased ATP levels and cell viability and the reduced cell apoptosis in HepG2 cells transfected with CYP3A5*6 were also investigated when compared to CYP3A5*1.

Conclusion

Our results suggest that CYP3A5 polymorphism influences sorafenib metabolism and pharmacotherapeutic effect in hepatic carcinomas . These data may help explain differential response to drug therapy for hepatocellular carcinoma, and they support the need for individualized treatment.
Conflicts between parents and clinicians: Tracheotomy decisions and clinical bioethics consultation
Authors: Klee Kristi , Wilfond Benjamin , Thomas Karen , Ridling Debra
Published: January 2022

Background:

The parent of a child with profound cognitive disability will have complex decisions to consider throughout the life of their child. An especially complex decision is whether to place a tracheotomy to support the child’s airway. The decision may involve the parent wanting a tracheotomy and the clinician advising against this intervention or the clinician recommending a tracheotomy while the parent is opposed to the intervention. This conflict over what is best for the child may lead to a bioethics consult.

Objective:

The study explores the conflicts that may arise around tracheotomy placements.

Research design:

This study is a retrospective cohort study of pediatric patients for whom a tracheotomy decision required a bioethics consult.

Participants and research context:

Pediatric patients aged birth to 18 years old with a bioethics consult for a tracheotomy decision conflict between April 2010 and December 2016. A standardized data collection tool was used to review notes entered by the palliative care team, social workers, primary clinical team interim summaries, and the bioethics consult service.

Ethical considerations:

The study was reviewed and approved by the medical center’s institutional review board.

Results:

There were 248 clinical bioethics consults during the identified study period. There were 31 consults involving 21 children where the word tracheotomy was mentioned in the consult, and 13 of the 21 consults were for children with profound cognitive disability.

Discussion and conclusion:

Clinicians need to be aware of their own biases when discussing a child’s prognosis and treatment options while also understanding the parents’ values and what the parent might consider to be burdensome in the care of their child and the acceptable burden for the child to experience.
Type A thymoma in a pet rabbit
Authors: Robson Halley R. , Yanez Ryan A. , Magestro Leanne M. , French Stephanie J. , Kiupel Matti
Published: January 2022

A 4-y-old, spayed female, mixed-breed domesticated rabbit ( Oryctolagus cuniculus domesticus) was presented because of progressive bilateral exophthalmos, with a large mediastinal mass in the cranial thorax. Palliative radiation therapy was elected, and 4 fractions of 5 Gy were delivered twice weekly under general anesthesia using 3-dimensional conformal radiation therapy for a total dose of 20 Gy, guided by an on-board cone beam CT scan. Quality-of-life and respiratory rate improved before sudden death that followed an episode of dyspnea. The overall survival time following initial diagnosis was 93 d, with 68 d after the first dose of radiation. An autopsy was performed, and the mass was diagnosed as a type A thymoma. The diagnosis was confirmed with positive immunohistochemical labeling of the neoplastic cells for cytokeratin 5/6 and cytokeratin 7.
Advancing Theory and Practice on Managing Dysfunctional Turnover: Developing an Improved Measure of Turnover Reasons
Authors: Maertz Carl P. , Keith Melissa G. , Raghuram Sumita , Porter Caitlin M. , Dalton Glenn L.
Published: January 2022

We examine turnover reasons for dysfunctional (i.e., high-performing or high-competency) leavers versus functional (i.e., low-performing or low-competency) leavers. In a United States retail bank, high performers reported wanting better advancement or development opportunities as their top turnover reason, whereas low performers mentioned wanting different job tasks, job insecurity, work stress, problems with coworkers, and generic problems with management more frequently than high performers. In an Indian IT consultancy firm, job performance and competency level were positively related to reporting problems with leadership/upper management, whereas performance was negatively related to reporting a specific alternative job offer. Through these studies, we develop a novel turnover reason measure for scholars and practitioners that assesses reason importance, enables the vital accumulation of data across studies, and increases diagnostic potential in exit or stay interviews/surveys. Finally, we offer directions for building theory and improving the management of high-performer turnover.
Giant Cell Tumor of Bone Versus Tenosynovial Giant Cell Tumor – Similarities and Differences
Authors: Kropivšek Luka , Pižem Jože , Mavčič Blaž
Published: January 2022

Giant cell tumor of bone (GCTB) and tenosynovial giant cell tumor (TGCT) share misleadingly similar names, soft texture and brown color macroscopically, osteoclast-like multinucleated giant cells microscopically and localisation in the musculoskeletal system. However, these two tumor types are biologically and clinically two distinct entities with different natural courses of progression and considerably different modes of surgical and medical treatment. In this article, we provide a detailed update on the similarities and the differences between both tumor types.

GCTB is a locally aggressive osteolytic bone tumor, commonly seen in patients in their third decade of life. It usually occurs as a solitary lesion in the meta-epiphyseal region of long bones. It can be diagnosed using plain radiographic imaging, CT radiography or MRI to estimate the tumor extent, soft tissue and joint involvement. GCTB is usually treated with intralesional excision by curettage. Systemically, it can be treated with bisphosphonates and denosumab or radiotherapy.

TGCT is a rare, slowly progressing tumor of synovial tissue, affecting the joint, tendon sheath or bursa, mostly seen in middle-aged patients. TGCT is usually not visible on radiographs and MRI is mostly used to enable assessment of potential bone involvement and distinguishing between two TGCT types. Localised TGCT is mostly treated with marginal surgical resection, while diffuse TGCT is optimally treated with total synovectomy and is more difficult to remove. Additionally, radiotherapy, intraarticular injection of radioactive isotopes, anti-TNF-α antibodies and targeted medications may be used.
Creators of the Vocabulary of Anglophone Psychology and Their Relationships
Authors: Benjafield John G.
Published: January 2022

The vocabulary of anglophone psychology largely developed during the 19th and early 20th centuries. The creators of this vocabulary include such well-known names as William James, Joan Riviere, E. L. Thorndike, and James Strachey. Along with others, they invented many new words and word meanings for psychology. The more a psychologist responded to the need for new vocabulary the more likely were they to be mentioned in publications. Moreover, linguistically creative psychologists occurred together in publications to a greater extent than less linguistically creative psychologists, with William James having the most co-occurrences. A network is presented that links each member of a sample of 59 linguistically creative psychologists to the other member of the sample with whom they most frequently co-occur (e.g., E. L. Thorndike co-occurs most frequently with William James). For each pair, we provide brief descriptions of their similarities and/or differences. There is also a cluster of translators who created new English words and word meanings in order to capture the meanings of words in other languages that had no satisfactory equivalents in English. Generally speaking, the more success psychologists have had in filling the lacunae in psychology’s vocabulary, the more they have been recognized by others.
Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes
Authors: Ramia Paul , Bodgi Larry , Mahmoud Dima , Mohammad Mohammad A , Youssef Bassem , Kopek Neil , Al-Shamsi Humaid , Dagher Mona , Abu-Gheida Ibrahim
Published: January 2022

Radiotherapy-related fibrosis remains one of the most challenging treatment related side effects encountered by patients with head and neck cancer. Several established and ongoing novel therapies have been studied with paucity of data in how to best treat these patients. This review aims to provide researchers and health care providers with a comprehensive review on the presentation, etiology, and therapeutic options for this serious condition.
Investigating the steady state characteristics of noncircular journal bearings lubricated with ferrofluid under concentric finite wire magnetic field
Authors: Rahmatabadi A. D. , Rashidi Meybodi R. , Zare Mehrjardi M. , Ghayoumizade F.
Published: January 2022

The aim of the present work is to investigate the steady state performance of noncircular hydrodynamic two, three and four lobe journal bearings, lubricated with ferrofluid under concentric finite wire magnetic field. Applying momentum and continuity equation, for ferrofluid under the applied magnetic field, modified Reynolds equation is obtained. Assuming linear behaviour for the magnetic material of the ferrofluid, the Reynolds equation is solved, using finite element technique to obtain pressure distribution then applied to study the effect of magnetic lubricant on various bearing performance characteristics such as load capacity, attitude angle, friction coefficient, friction force and side leakage flow. The results indicate with increasing magnetic force coefficient, side leakage in noncircular bearings and friction coefficient is significantly reduced and improvement in load bearing capacity can be seen at the most values of eccentricity ratio, especially in two lobe noncircular bearing. The results also show that the eccentricity ratio has an effective influence on bearing performance characteristics, if the magnetic field and geometric configuration are selected properly.
L2 Spanish vocabulary teaching in US universities: Instructors’ beliefs and reported practices
Authors: Sánchez-Gutiérrez Claudia H. , Robles-García Pablo , Serrano Mercedes Pérez
Published: January 2022

Studies on teachers’ beliefs about vocabulary learning and teaching have focused, so far, on English as a second language (L2), or foreign language (FL), in different contexts but little attention has been given to other L2s and FLs. In this study, 15 Spanish L2 instructors at large universities were interviewed in order to better understand where they stand when it comes to (1) the importance they give to vocabulary, as compared to grammar, in their classes, (2) how they decide which words to teach, and (3) how they assess students’ word knowledge. These interviews were subsequently analysed following Grounded Theory. Most instructors declared favoring grammar over vocabulary in their courses because the former is seen as more challenging and useful than the latter and because institutional practices and materials also present such a preference. When it comes to vocabulary selection, most of them declared feeling insecure in their decisions due to lack of access to useful resources and to vocabulary goals not being stated clearly anywhere in the syllabi. This lack of clarity when it comes to vocabulary learning goals also results in doubts about the usefulness of even evaluating word learning at all and an overreliance on informal assessments.
Feminized need and racialized danger: Punitive therapeutics and historical addict tropes in a Midwestern drug court
Authors: Horowitz Veronica , Gowan Teresa
Published: January 2022

Drug courts are widely praised as a therapeutic alternative to mass incarceration. Using ethnographic discourse analysis, our intersectional comparison of a Midwestern court demonstrates how gender and race create differentiated and unequal rehabilitative projects. Striking differences in treatment, sanctions, and requirements demonstrate the lasting power of long-standing historical addiction tropes. Our primarily white and African-American site re-inscribed the historical polarization between “white slaves” and “drug zombies”, between the (traumatized female) “involuntary addict” and the dangerous agency of the (racialized) male “criminal addict”. The explicit gender differentiation between therapy for women and work for men was thus cross-cut by race, with talk therapy for white women and neuro-scientific medicalization for white men set against deep racio-cultural reform for African-Americans. While Black women were encouraged to take on intensive mothering, Black men were subjected to the highest surveillance and suspicion, their struggles in the labor and housing markets misrecognized as cultural deficiency.
‘Pay close attention to what my eyes are saying without having to spell it out’: Heterosexual relations and discourses of sexual communication in #MeToo commentaries
Authors: Waling Andrea
Published: January 2022

This paper explores how concepts of sexual communication and sex are discussed in #MeToo commentaries. Previous research has focused primarily on questions of consent, gendered power relations and sexual violence against women. Drawing from work that has called for more reflexive considerations of desire and pleasure in #MeToo, I undertake a critical feminist discourse analysis of over 163 traditional news, online magazine and social news articles commenting on #MeToo, sexual communication, dating and heterosexual relations between men and women. The findings of this analysis note discourses underpinning tensions between what constitutes ideal or appropriate forms of sexual communication, uncertainties as to what effectively makes sex ‘good’ or ‘bad’, moralisations regarding how ‘good’ and ‘bad’ sex are possible, and contradicting accounts of women’s capacity for sexual empowerment. Through highlighting the incongruities in expectations as to how individuals should proceed sexually and romantically in a #MeToo era, I conclude with a discussion on how we can think about such relations within a consideration of a ‘self-in-process’ and ‘subject-act-ivity’ framework.
Complication rates in operatively managed ankle fracture/dislocations: The effect of pre-reduction imaging and compliance with British Orthopaedic Association Standards for Trauma 12 guidance
Authors: O'Dowd Dominic , Ward Alex , Phoon Kar , Pitcher Feargus , Amos Lucy , Butler Jennifer , Brewer Paul , Davies Mark , Chadwick Carolyn , Davies Howard , Blundell Chris
Published: January 2022

Introduction

The British Orthopaedic Association Standards for Trauma (BOAST 12) guidelines for the management of ankle fractures aims to optimize recovery and reduce complications. Within the emergency department (ED), they advised urgent reduction of clinically deformed ankles, with radiographs prior only if this would not cause an unacceptable delay. The primary aim of this study was to assess the effect of time to acceptable reduction on the risk of complications and time to definitive reduction.

Methods

This was a retrospective observational study of patients presenting with ankle fracture dislocations between 2013 and 2017. Patients were divided into two groups with and without radiographs prior to reduction of their injury.

Results

A total of 242 patients were identified. The time taken from arrival to achieving an acceptable reduction was significantly longer in patients who received pre-reduction radiographs versus patients who did not (184.5 min vs 82, p < .00). The key finding of this follow-up study was that the overall risk of complications and soft tissue complications was not associated with an increased time to reduction ( p = .62). Time to definitive operative management was similar between the two sub-groups (immediate reduction 1 day vs 2, p = .72).

Conclusion

This study has shown that the use of pre-reduction radiographs in the management of ankle fracture dislocations significantly increases the time to reduction. However, this is not associated with an increased risk of complications or a longer time to definitive management. Further research is needed into the prognostic effect of prolonged ankle dislocation on soft tissues and long-term functional outcome.
Seeking anonymity on the Internet: The knowledge accumulation process and global usage of the Tor network
Authors: Chen Zhicong , Jardine Eric , Fan Liu Xiao , Zhu Jonathan J. H.
Published: January 2022

The Onion Router (Tor) network is one of the most prominent technologies for accessing online resources while preserving anonymity. Effectively employing the technology is not a trivial process and involves the following steps: (1) motivated by needs, (2) becoming aware of and learning the technology, and (3) realizing desired purposes by usage. Using country-level panel data, this study examines the knowledge accumulation process through which motivated users eventually employ Tor. The results suggest that Tor is often searched in less free countries for censorship circumvention, while it is employed for Dark Web activities in more free countries. There is also an indirect relationship between being aware of the technology and its usage through how-to knowledge accumulation. This study is the first attempt to understand the role of knowledge accumulation in the global usage of Tor. The findings provide insights into the worldwide concerns of online privacy and Dark Web regulation.
Influence of heat treatment on the suitability for clinching of the aluminium casting alloy AlSi9
Authors: Neuser M. , Böhnke M. , Grydin O. , Bobbert M. , Schaper M. , Meschut G.
Published: January 2022

In many manufacturing areas, multi-material designs are implemented in which individual components are joined together to form complex structures with numerous joints. For example, in the automotive sector, cast components are used at the junctions of the body and joined with different types of sheet metal and extruded profiles. To be able to join structures consisting of different materials, alternative joining technologies have emerged in recent years. This includes clinching, which allows assembling of two or more thin sheet metal and casting parts by solely cold forming the material. Clinching the brittle and usually less ductile cast aluminium alloys remains a challenge because the brittle character of the cast aluminium alloys can cause cracks during the forming of the clinched joint. In this study, the influence of the heat treatment time of an aluminium casting alloy AlSi9 on the joinability in the clinching process is investigated. Specific heat treatment of the naturally hard AlSi9 leads to a modification of the eutectic microstructure, which can increase ductility. Based on this, it will be examined if specific clinching die geometries can be used, which achieve an optimized geometrical formation of the clinched joint. The load-bearing capacities of the clinched joints are determined and compared by shear tensile and head tensile tests. Furthermore, the joints are examined microscopically to investigate the influence of the heat treatment on the failure behaviour during the load-bearing tests as well as crack initiation within the joining process.
The Chinese Herbal Formula Ruyan Neixiao Cream Inhibits Angiogenesis of Precancerous Breast Lesions via Regulation of Ras/Raf/MEK/ERK Signaling Pathway
Authors: Lin Shujun , Jiang Xuefeng , Zhang Guijuan , Xiao Xinqin , Ma Xinyi , Wu Jieyan , Qiu Dan , Li Xinyuan , Yan Xianxin , Ma Min
Published: January 2022

Ruyan Neixiao Cream (RUc) is a traditional Chinese herbal formula which can effectively inhibit the angiogenesis of breast precancerous lesions. In order to reveal the specific mechanism, we carried out experiments in vitro and in vivo. We found that the conditioned medium of MCF-10AT cells treated with RUc transdermal solution (RUt) could significantly inhibit the proliferation, migration, invasion, tube formation of HUVECs and the capillary formation of rat aortic rings. RUt may down-regulate the expression of VEGF, MMP2, and MMP9 in MCF-10AT medium by down-regulating miR-21 and up-regulating TIMP-3 and RECK. We further confirmed in rats that the microvascular density of precancerous lesions decreased significantly after external use of RUc, which may be related to the inhibition of Ras/Raf/MEK/ERK signaling pathway related proteins. Presumptively, RUc may inhibit the angiogenesis of breast precancerous lesions by inhibiting Ras/Raf/MEK/ERK signaling pathway, thus relieving the inhibition of miR-21 on TIMP-3 and RECK, then down-regulating the secretion of angiogenic factors.
Cooperative NOMA system with incremental relaying over Nakagami-m fading channels
Authors: Wang Zhenling , Qiao Dawei
Published: January 2022

In our article, we apply incremental relay to the cooperative non-orthogonal multiple access network, in which the incremental relay employs amplify and forward protocol. The main communication process of the system is that one base station transmits messages to multiple non-orthogonal multiple access users with the assistance of incremental relay. In addition, we deeply analyze the outage behavior of the incremental cooperative non-orthogonal multiple access system over Nakagami- m fading channels. Specifically, the exact and asymptotic closed-form expressions of outage probabilities are all derived for paired users u n and u f, which are nearby and distant user, respectively. On this basis, the diversity orders of the paired users u n and u f are also acquired, which are μ ( n+ f+1) and μ( f+1). We also investigate the conventional cooperative non-orthogonal multiple access system, which serves as a benchmark of the incremental cooperative non-orthogonal network. Through the proof, we can conclude that the outage behavior of the distant u f has been improved by adopting incremental relay. Finally, the performance of the system is simulated. The following conclusions can be drawn from the numerical simulation results: (1) the outage performance and throughput of the system have been significantly improved by using the incremental relay protocol; (2) as the multipath fading [Formula: see text] increases, the outage performance of the system becomes better; and (3) the greater the difference in channel gain between paired users, the incremental cooperative non-orthogonal system can achieve better outage performance.
Web-Based Intravenous Fluid Treatment Monitoring Platform in Nursing Station
Authors: Kim Yoonji , Seol Jaehwang , Lee Hyomin , Lee Jaekyeong , Park Jeongyun , Kim Kwang Gi
Published: January 2022

Background

Intravenous fluid treatment is the most common way to take care of inpatients. Because of the global pandemic, the number of inpatients is increasing rapidly, leading to constant demand in the contactless system.

Purpose

In this article, we suggest a web-based intravenous fluid treatment monitoring platform in the nursing station to unburden the medical staff’s workload.
Campus Sexual Harassment, Other Violence, and Racism, Oh my! Evidence From Black Women Undergraduates for a Culturally Competent University Approach to Title IX
Authors: Gómez Jennifer M.
Published: January 2022

Relevant for Title IX federal legislation, the purpose of the current study is to examine cultural betrayal (within-group perpetrator) and sexual harassment (SH) with other violence and racial discrimination on Black women undergraduates’ mental health. In a 60-minute online study ( N = 162), over 50% experienced campus SH and other violence and/or racial discrimination, with multi-victimization being related to anxiety and other mental health outcomes. Cultural betrayal SH did not predict mental health when controlling for between-group SH. Implications include the 2019 Critical-Interdisciplinary Sexual Violence Research Summit’s comprehensive research agenda: Intersectional Approaches, Perpetration, Communications, Beyond Policy, and Sexual Violence and Equity.
Prognostic impact of pretreatment serum superoxide dismutase activity in patients with locoregionally advanced nasopharyngeal carcinoma
Authors: Qiu Wenze , Jiang Jiali , Zhan Zejiang , Huang Laiji , Deng Jin , Ye Jiacai , Li Guo , Liao Kai , Zhang Huanhuan , Ding Yan , Yuan Yawei , Zheng Ronghui
Published: January 2022

Purpose

To evaluate the prognostic effect of pretreatment serum superoxide dismutase (SOD) activity in locoregionally advanced nasopharyngeal carcinoma.

Methods

A total of 498 patients diagnosed with stage III–IVA nasopharyngeal carcinoma between January 2013 and December 2016 were involved in this study. The X-tile program was used to determine the cut-off value of pretreatment serum SOD activity based on disease-free survival. Kaplan–Meier methods and Cox proportional hazards models were used to evaluate the impact of serum SOD levels on survival outcomes. The receiver operating characteristic (ROC) curve analysis was used to compare the prognostic value of clinical stage, pretreatment serum SOD level, and the combination of them regarding disease-free survival.

Results

Based on the X-tile plot, the optimal cutoff value of pretreatment serum SOD activity for disease-free survival was 146.0U/mL. As a dichotomous variable, SOD was significantly higher in non-keratinizing differentiated disease ( P = 0.027) and early T stage ( P = 0.011). Compared with the lower subset, higher SOD activity predicted an inferior 3-year rates of overall survival (84.6 vs. 94.7%, P < 0.001), distant metastasis-free survival (78.3 vs. 92.8%, P < 0.001) and disease-free survival (78.2 vs. 92.8%, P < 0.001). Multivariate analysis verified that the SOD activity was an independent prognostic indicator to predict distant metastasis, disease progression, and death. The area under the ROC curve (AUC) of the combination was superior to that of clinical stage or SOD alone for disease-free survival (both P < 0.01).

Conclusion

Serological SOD activity before treatment is an important prognostic indicator for patients with stage III–IV non-metastatic nasopharyngeal carcinoma undergoing chemoradiation therapy.
Gluten-free diet in postural orthostatic tachycardia syndrome (POTS)
Authors: Zha Kate , Brook Jill , McLaughlin Abigail , Blitshteyn Svetlana
Published: January 2022

Objectives

Postural orthostatic tachycardia syndrome (POTS) is a chronic disorder of the autonomic nervous system that is associated with orthostatic intolerance (OI) and gastrointestinal (GI) symptoms. We aimed to determine if a gluten-free diet (GFD) may be an effective treatment in patients with POTS.

Methods

Patients with confirmed POTS and without celiac disease who followed GFD for  4 weeks retrospectively completed pre- and post- GFD COMPASS-31 questionnaires. Paired-samples t-tests were conducted to compare COMPASS-31 scores before and after adopting GFD.

Results

All 20 patients (all females, age 16–62 years (mean age 33)), had POTS symptoms for 1–30 years (mean 10.8, SD  =  10.23 years). Eleven patients had co-morbid mast cell activation syndrome, and 8 had hypermobile Ehlers-Danlos syndrome. Pre-GFD COMPASS-31 scores (mean 57.8) were significantly higher than post-GFD scores (mean 38.2, t(19) = -8.92, p < 0.00001), with the largest improvement noted in the OI (p < 0.00001), vasomotor, (p  =  0.0034), and GI (p  =  0.0004) domains and with a mean reduction in total COMPASS-31 score by 33.9% after implementing GFD. All patients reported improved symptoms on GFD with mean self-assessed improvement of 50.5% (range 10-99%).

Discussion

GFD may be effective in reducing the symptom burden in patients with POTS, particularly in the OI, vasomotor, and GI symptom domains. Large prospective studies are necessary to confirm whether GFD is an effective long-term treatment option for patients.
Intimate partner violence and COVID-19 among reproductive age women: A community-based cross-sectional survey, Ethiopia
Authors: Shewangzaw Engda Abayneh , Dargie Wubetu Abate , Kasahun Amogne Fetene , Moltot Kitaw Tebabere
Published: January 2022

Introduction:

Intimate partner violence is one of the most common psychological, physical, and sexual assaults toward women which suit the entire life of women, and nowadays, the magnitude accelerates due to coronavirus pandemic. Hence, this study was aimed to examine the prevalence of intimate partner violence and predictors during coronavirus among childbearing-age residents in Debre Berhan.

Methods:

A community-based cross-sectional survey was employed from 1 May to 1 July 2020. Eight items of women abuse screening tool were used to estimate intimate partner violence. Trained data collectors directly interview randomly selected participants. The data were entered using Epi-info V. 7 and analyzed using SPSS V. 23. Descriptive statistics were used to determine the prevalence of intimate partner violence and the frequency distribution of other variables. During bivariate analysis, predictor variables with a p-value less than 0.25 were nominated to further analysis. An adjusted odds ratio with a 95% confidence interval was used and a p-value less than 0.05 was considered statistically significant.

Result:

A total of 700 participants were included with a response rate of 95.1%. The prevalence of intimate partner violence in the past single year was 19% with 95% confidence interval = 16.1–21.9. Besides, the prevalence of emotional (19.9%, 95% confidence interval = 16.9–22.8), sexual (10.9%, 95% confidence interval = 8.6–13.2) and physical (9.4%, 95% confidence interval = 7.3–11.6) violence was reported. Women with depressive symptoms, overweight, suicidal ideation, and body image disturbance were significantly associated with intimate partner violence, but not educational status, employment, income, stressful life events, lifetime alcohol use, suicidal attempt, and abortion.

Conclusion and recommendation:

Nearly one out of five interviewed participants had intimate partner violence. Being overweight, having poor body image, and having depression increase intimate partner violence. Special preventive measures and treatment, and other legal services should be taken to alleviate the predictor variables and intimate partner violence.
Diagnosing vascular cognitive impairment: Current challenges and future perspectives
Authors: Biesbroek J Matthijs , Biessels Geert Jan
Published: January 2022

Cerebrovascular disease is a major cause of cognitive decline and dementia. This is referred to as vascular cognitive impairment (VCI). Diagnosing VCI is important, among others to optimize treatment to prevent further vascular injury. This narrative review addresses challenges in current diagnostic approaches to VCI and potential future developments. First we summarize how diagnostic criteria for VCI evolved over time. We then highlight challenges in diagnosing VCI in clinical practice: assessment of severity of vascular brain injury on brain imaging is often imprecise and the relation between vascular lesion burden and cognitive functioning shows high intersubject variability. This can make it difficult to establish causality in individual patients. Moreover, because VCI is essentially an umbrella term, it lacks specificity on disease mechanisms, prognosis, and treatment. We see the need for a fundamentally different approach to diagnosing VCI, which should be more dimensional, including multimodal quantitative assessment of injury, with more accurate estimation of cognitive impact, and include biological definitions of disease that can support further development of targeted treatment. Recent developments in the field that can form the basis of such an approach are discussed.
Ethanol Extract of Elaeagnus glabra f. oxyphylla Branches Alleviates the Inflammatory Response Through Suppression of Cyclin D3/Cyclin-Dependent Kinase 11p58 Coupled to Lipopolysaccharide-Activated BV-2 Microglia
Authors: Lim Hye-Sun , Sohn Eunjin , Kim Yu Jin , Kim Bu-Yeo , Kim Joo-Hwan , Jeong Soo-Jin
Published: January 2022

Neuroinflammation plays a pivotal role in the pathogenesis of neurodegenerative diseases and is characterized by microglial dysregulation. Here, we explored the beneficial effects of a leaf extract of Elaeagnus glabra f. oxyphylla (EGFO), a native medicinal plant to Korea, South China, Japan, and Taiwan, on neuroinflammation using lipopolysaccharide (LPS)-stimulated BV-2 microglia. Levels of the inflammatory mediators were determined by enzyme-linked immunosorbent assays and reverse transcription–polymerase chain reaction. The phospho levels of mitogen-activated protein kinases, which are key kinase molecules in the inflammatory signaling pathway in microglia, were analyzed by Western blotting. Treatment with EGFO significantly suppressed the LPS-mediated induction of nitric oxide and prostaglandin E2. Consistently, EGFO treatment in LPS-stimulated BV-2 cells markedly reduced the inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels. The best concentration of EGFO that could reduce TNF-α and IL-6 was 100 μg/mL. EGFO relatively reduced the messenger RNA expression of TNF-α and IL-6 by 0.36 and 0.32-fold ratio, respectively, compared to LPS treatment. Moreover, EGFO markedly reduced the phospho levels of p38 and the c-jun N-terminal kinase. Furthermore, antibody microarray and immunoblotting data revealed that the pharmacological mechanisms driving the antineuroinflammatory action of EGFO involve prevention of the cyclin D3/cyclin-dependent kinase 11p58 (CDK11p58) interaction. In conclusion, our results demonstrate that EGFO alleviates the inflammatory response through the suppression of cyclin D3/CDK11p58 coupling in LPS-activated BV-2 microglia. We propose the potential of EGFO as a novel drug candidate for neurodegenerative diseases by targeting neuroinflammation.
Towards a Renovation of the Laclauian Paradigm
Authors: Rueda Daniel
Published: January 2022

This article provides a renovation of Ernesto Laclau’s theories of political competition and collective identity-building for their better application at an empirical level. It does so not as a critique but as a way to make the Laclauian approach more operational and rigorous from a methodological perspective. The key goal is to make available a form of discourse analysis that centers on the political sphere and has two key characteristics. The first is an emphasis on the role of what Antonio Gramsci called “organic ideologies” in political identity-building. The second is the differentiation between a descriptive and a subjective level of analysis. The article intends to initiate a debate on the prospects of the Laclauian approach both with its advocates and its detractors.
Comparison Between Arthroscopic and Histological International Cartilage Repair Society Scoring Systems in Porcine Cartilage Repair Model
Authors: Puhakka Jani , Salonius Eve , Paatela Teemu , Muhonen Virpi , Meller Anna , Vasara Anna , Kautiainen Hannu , Kosola Jussi , Kiviranta Ilkka
Published: January 2022

Objective

The arthroscopic and histological International Cartilage Repair Society (ICRS) scores are designed to evaluate cartilage repair quality. Arthroscopic ICRS score can give a maximum score of 12 and the histological score can give values between 0% and 100% for each of its 14 subscores. This study compares these methods in an animal cartilage repair model. This study hypothesizes that there is a significant correlation between these methods.

Design

A chondral defect was made in the medial femoral condyle of 18 pigs. Five weeks later, 9 pigs were treated with a novel recombinant human type III collagen/polylactide scaffold and 9 were left untreated to heal spontaneously. After 4 months, the medial condyles were evaluated with a simulated arthroscopy using the ICRS scoring system followed by a histological ICRS scoring.

Results

This porcine cartilage repair model produced repaired cartilage tissue ranging from good to poor repair tissue quality. The mean arthroscopic ICRS total score was 6.8 (SD = 2.2). Histological ICRS overall assessment subscore was 38.2 (SD = 31.1) and histological ICRS average points were 60.5 (SD = 19.5). Arthroscopic ICRS compared with histological ICRS average points or its overall assessment subscore showed moderate correlation (r = 0.49 and r = 0.50, respectively). The interrater reliability with the intraclass correlation coefficients for arthroscopic ICRS total scores, histological ICRS overall assessment subscore, and ICRS average points showed moderate to excellent reliability.

Conclusions

Arthroscopic and histological ICRS scoring methods for repaired articular cartilage show a moderate correlation in the animal cartilage repair model.
Navigation in Contour-Drawn Scenes Using Augmented Reality
Authors: Sawada Tadamasa , Mendoza Arvizu Alejandro , Farshchi Maddex , Kiba Alexandra
Published: January 2022

The visual system can recover 3D information from many different types of visual information, e.g., contour-drawings. How well can people navigate in a real dynamic environment with contour-drawings? This question was addressed by developing an AR-device that could show a contour-drawing of a real scene in an immersive manner and by conducting an observational field study in which the two authors navigated in real environments wearing this AR-device. The navigation with contour-drawings was difficult in natural scenes but easy in urban scenes. This suggests that the visual information from natural and urban environments is sufficiently different and our visual system can accommodate to this difference of the visual information in different environments.