bluuebunny/crossref_metadata_2025 huggingface dataset:
Automatic quantitative measurement of left atrial pressure using mitral regurgitation spectrum: clinical study on comparison with floating catheter
Authors: Jin Yan , Wen Chao-yang , Yue Fengjie , Wang Huishan , Yin Liancheng , Zhao Yang , Mao Keming , Xin Fangran
Published: October 2022

Introduction

To explore how to measure LAPEq accurately and quantitatively, that is, the left atrial pressure (LAP) measured and calculated by equation method using mitral regurgitation spectrum.

Methods

The mitral regurgitation spectrum, pulmonary arteriolar wedge pressure (PAWP) and invasive arterial systolic pressure of radial artery of 28 patients were collected simultaneously, including 3 patients with rheumatic heart disease, 15 patients with mitral valve prolapse and 10 patients with coronary artery bypass grafting, patients with moderate or above aortic stenosis were excluded. LAPBp (Doppler sphygmomanometer method), LAPEq (Equation method) and LAPC (Catheter method) were measured synchronously, and the measurement results of the three methods were compared and analyzed. A special intelligent Doppler spectrum analysis software was self-designed to accurately measure LAPEq. This study had been approved by the ethics committee of the Northern Theater General Hospital (K-2019-17), and applied for clinical trial (No. Chictr 190023812).

Results

It was found that there was no significant statistical difference between the measurement results of LAPC and LAPEq (t = 0.954, P = 0.348), and significant correlation between the two methods [r = 0.908(0.844, 0.964), P < 0.001]. Although the measurement results of LAPC and LAPBP are consistent in the condition of non-severe eccentric mitral regurgitation, there are significant differences in the overall case and weak correlation between the two methods [r = 0.210, (−0.101, 0.510), P = 0.090]. In MVP patients with P1 or P3 prolapse, the peak pressure difference of MR was underestimated due to the serious eccentricity of MR, which affected the accuracy of LAPBP measurement.

Conclusions

It was shown that there is a good correlation between LAPEq and LAPC, which verifies that the non-invasive and direct quantitative measurement of left atrial pressure based on mitral regurgitation spectrum is feasible and has a good application prospect.
Navigating pregnancy and early motherhood in prison: a thematic analysis of mothers’ experiences
Authors: Sapkota Diksha , Dennison Susan , Allen Jyai , Gamble Jenny , Williams Corrie , Malope-Rwodzi Nomxolisi , Baar Laura , Ransley Janet , Renae McGee Tara
Published: October 2022

Background

Maternal imprisonment negatively impacts mothers and their children and is likely to have lifelong and intergenerational sequelae. In many jurisdictions nationally and internationally, young children (usually those less than 5 years) can reside with their mothers in prison. However, there is considerable debate regarding the impact of prison environments on incarcerated mothers and their children who are born, and/or raised in prison. Research to date on the pregnancy and mothering experiences of imprisoned mothers and their preferences for care arrangements for their babies and young children is limited.

Methods

This study was part of the Transforming Corrections to Transform Lives project, in which workshops were conducted with imprisoned mothers to understand their needs while in custody and post-release, and the kind of supports and system changes that are required to meet those needs. Incarcerated mothers (n = 75) participated in seven workshops conducted across four Queensland prisons. Themes were generated through reflexive thematic analysis.

Results

Three themes characterised mothers’ experiences of being pregnant and undertaking a mothering role of a young child while in prison. First, for most mothers, imprisonment adds vulnerability and isolation during pregnancy and childbirth. Second, although mothers felt that residing together with their children in prison motivated them to change for a better future, they were concerned about the potential negative impact of the prison environment on the child’s development. Lastly, most mothers voiced losing autonomy and agency to practice motherhood independently within custodial settings. Mothers expressed a need for the correctional system to be adapted, so it is better equipped to address the unique and additional needs of mothers with young children.

Conclusion

Mothers’ experiences indicated that the correctional system and policies, which were predominantly designed for men, do not adequately address the varied and complex needs of pregnant women, mothers, and their young children. Imprisonment of pregnant women and mothers with young children should be the last resort, and they should be provided with holistic, individually tailored support, most preferably in community settings, to address their multiple intersecting needs.
Bridging the gap between healthcare professions’ regulation and practice: the “lived experience” of community pharmacists in Ireland following regulatory change
Authors: Lynch Matthew , Kodate Naonori , Hickey Conor , O’Leary Aisling C.
Published: October 2022

Background

Reforms to models of health and care regulation internationally have adapted to address the challenges associated with regulating healthcare professionals. Pharmacists in Ireland entered a new era of regulation with the enactment of the Pharmacy Act in 2007 which significantly updated the law regulating pharmacy in Ireland and expanded the regulatory scope considerably. An earlier study in 2017 examined the experiences of 20 community pharmacists of the Act. This follow-up study aimed to expand the scope of the original study to all community pharmacists in Ireland, to report their “lived experience” of the regulatory model introduced by the Act, assessing its impact on their professional practice using the principles of “better regulation”.

Methods

Survey methodology was used to assess the perception of all community pharmacists registered with the Pharmaceutical Society of Ireland of the Act, as implemented, on their practice using an experimental design based on the seven principles of “Better Regulation”. Descriptive statistics analyzed quantitative responses while answers from open-ended questions were analyzed using a combination of a modified framework analysis and a qualitative content analysis.

Results

Respondents agreed that the Act was necessary, although its implementation by the regulator was largely not viewed as fulfilling the remaining “Better Regulation” principles of being effective, proportional, consistent, agile, accountable and transparent. In particular, its proportionality was questioned. This resulted in pharmacists perceiving that their professional competency to act in the best interests of their patients was not appropriately acknowledged by the regulator, which in turn compromised their ability to provide optimal care for their patients.

Conclusion

While healthcare professional regulation must primarily be concerned with public protection, it must also have regard to its impact on those delivering healthcare services. The findings highlight the challenge internationally of balancing rigidity and flexibility in professional health and care regulation, and the importance of a regulatory conversation occurring between those regulating and those regulated. This would serve to promote mutual learning and understanding to create a responsive approach to regulation, underpinned by mutual trust, effective risk assessment and adherence to the principles of “Better Regulation”.
Impact of university students’ awareness and attitudes on vaccination practices for human papillomavirus, and perception on self-sampling for cervical cancer screening
Authors: Fahrni Mathumalar Loganathan , Azni Muhamad Zabidi , Rusdi Nurhani Syafiqah Mohd , Choo Chee-Yan , Isa Khairil Anuar Md , Babar Zaheer-Ud-Din
Published: October 2022

Background

The burden of Human Papilloma Virus (HPV)-associated cancer remains high in developing nations.

Aims

To assess the impact of self-reported awareness and attitudes on vaccination practices, and the perception on self-sampling for cervical cancer screening.

Methods

A 12-month survey using purposive sampling of females attending an urban public university was conducted. SPSS version 25 was used to compare the responses for students enrolled in health vs non-health related programmes.

Results

Of the 290 questionnaires distributed, 240 were returned (response rate = 83%) in approximately equal proportion from the faculties of Health Science and Pharmacy (n = 127), and from the Hotel and Tourism, Business Management, and Art and Design (n = 113) faculties. About one-third (28.8%) had completed 3 shots, 19.6% received the first shot, 11.4% had scheduled appointments for first shots while 40.2% were both unvaccinated and had not scheduled any appointment. Most (71%) were aware of the HPV vaccines while 50.5% were unaware that HPV vaccines were also available for men. Students enrolled in health-related programmes were 3.2 times more perceptive to the benefits of vaccination particularly in preventing spread to their partners (OR 3.2, 95% CI 1.3–3.41, p = 0.006) than their counterparts. A weak-positive correlation was observed between knowledge and vaccination practices (r = 0.2, p = 0.001). The level of knowledge on HPV and its vaccine was greater for health-related (Mdn = 6.5) than for students of non-health related (Mdn = 1.5) programmes (U = 2790.5, p-value = 0.00). Attitudes towards immunisation were influenced by perceived benefits versus risks for side effects, cost barriers, and influences of primarily their doctors and parents. The study was limited in that relationship statuses were used to estimate sexual history as direct questions were unanswered in the pilot survey.

Conclusion

HPV vaccine uptake for an immunisation-targeted young female population is low despite moderate knowledge levels. It is plausible that the low rates among females enrolled in particularly the non-health programmes were impacted by misperceived vaccine-associated risks, and misconception that testing and vaccination for HPV and cervical cancer were for those married or sexually active. Self-sampling could offer a potential alternative to sampling via pelvic examination, particularly for societies where premarital sex is seen as a taboo.
Role of primary care pharmacists in the post-hospital discharge care of patients: a scoping review protocol
Authors: Yahya Faiza , Nazar Hamde , Hadi Muhammad Abdul
Published: October 2022

Background

Evidence has shown that there is a significant problem with medication safety when patients are transferred between settings. The role of community pharmacists and hospital pharmacists in facilitating transition of care has been well-researched. However, with the developing role of pharmacists in general practice as part of a multi-disciplinary team, little is known about their role in improving transition of care when patients move from secondary to primary care. The key objective of this scoping review is to understand the nature and extent of the role of primary care pharmacists for patients recently discharged from secondary care.

Methods

This scoping review will follow the Joanna Briggs Institute (JBI) methodology for scoping review underpinned by the Arksey and O’Malley methodology and reported in accordance with the Preferred Reporting Items for Systematic Reviews Extension for Scoping Reviews (PRISMA-ScR) guidelines. The following electronic databases will be systematically searched: MEDLINE, EMBASE, PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science and NICE Evidence. Reference lists of included full texts will be searched for relevant papers, in addition to grey literature which includes websites of relevant professional organisations. Primary studies, published in the English language that involved a primary care pharmacist-led intervention post-hospital discharge will be included. Two independent reviewers will screen studies against eligibility criteria and use a piloted data extraction form to extract data related to the review questions. The data will be presented in tabular form and assessed for key themes to identify gaps and inform future research.

Discussion

This scoping review will map current evidence surrounding the role of primary care pharmacists in the post-hospital discharge care of patients. Findings will inform ongoing research to support safer transfer-of-care post-hospital discharge and identify ways in which collaboration between healthcare professionals can be improved. This review anticipates guiding the inclusion of patient and public involvement (PPI) at the consultation stage to validate and build on the findings.
Genetic engineering and raising temperature enhance recombinant protein production with the cdna1 promoter in Trichoderma reesei
Authors: Jiang Shanshan , Wang Yue , Liu Qin , Zhao Qinqin , Gao Liwei , Song Xin , Li Xuezhi , Qu Yinbo , Liu Guodong
Published: October 2022

The fungus Trichoderma reesei is a powerful host for secreted production of proteins. The promoter of cdna1 gene, which encodes a small basic protein of unknown function and high expression, is commonly used for constitutive protein production in T. reesei. Nevertheless, the production level of proteins driven by this promoter still needs to be improved. Here, we identified that the region 600- to 700-bp upstream of the start codon is critical for the efficiency of the cdna1 promoter. Increasing the copy number of this region to three improved the production of a heterologous β-mannanase by 37.5%. Screening of several stressful conditions revealed that the cdna1 promoter is heat inducible. Cultivation at 37 °C significantly enhanced the production of β-mannanase as well as a polygalacturonase with the cdna1 promoter compared with those at 30 °C. Combing the strategies of promoter engineering, multi-copy gene insertion, and control of cultivation temperature, β-mannanase of 199.85 U/mL and relatively high purity was produced in shake flask, which was 6.6 times higher than that before optimization. Taken together, the results advance the understanding of the widely used cdna1 promoter and provide effective strategies for enhancing the production of recombinant proteins in T. reesei.

Graphical Abstract
Metal contamination in a sediment core from Osaka Bay during the last 400 years
Authors: Nitzsche Kai Nils , Yoshimura Toshihiro , Ishikawa Naoto F. , Kajita Hiroto , Kawahata Hodaka , Ogawa Nanako O. , Suzuki Katsuhiko , Yokoyama Yusuke , Ohkouchi Naohiko
Published: October 2022

Osaka Bay adjacent to the Kyoto–Osaka–Kobe metropolitan area was affected by severe metal pollution during the twentieth century; yet little is known about the trace metal sources and pre-industrial human activities. We have determined the elemental concentrations and zinc stable isotope ratios (δ66Zn) in bulk sediments and the trace metal concentrations in chemical fractions of a 9-m-long sediment core from Osaka Bay. Our goals were (1) to reconstruct the historical trace metal contamination, and (2) to identify anthropogenic Zn sources and the solid phases of anthropogenic trace metals. The core provided a continuous environmental record of the last 2300 years based on radiocarbon dating of molluscan shells. Copper, Zn, and Pb showed an initial enrichment from the 1670s AD, which could be caused by human activities due to an increasing population. In agreement with previous findings, the trace metal concentrations slightly increased from the 1870s, strongly increased from the beginning of the twentieth century, and peaked around 1960 before environmental pollution control laws were enacted. Increasing trace metal concentrations in the acid-labile and reducible fractions obtained by the Community Bureau of Reference (BCR) sequential extraction procedure toward the surface indicate carbonates and Mn oxyhydroxides were the primary fractions for anthropogenic trace metals. The δ66Zn values (1) were constant until the 1940s, suggesting that the average δ66Zn of industrial sources was indistinguishable from that value of the natural background, (2) showed a slight decrease from the 1950s and remained constant until the present, and (3) fell in a binary mixing process between a lithogenic (~ + 0.27‰) and an anthropogenic endmember (~ + 0.17‰), the latter likely representing a mixture of various Zn sources such as road dust, tire wear, industrial effluents, and effluents from wastewater treatment plants. We conclude the combination of Zn stable isotopes together with chemical fractions obtained by the BCR method represents a promising approach to assess the trace metal sources and their potential mobility in sediment cores from anthropogenically affected coastal areas.
Shortened duration whole body 18F-FDG PET Patlak imaging on the Biograph Vision Quadra PET/CT using a population-averaged input function
Authors: van Sluis Joyce , van Snick Johannes H. , Brouwers Adrienne H. , Noordzij Walter , Dierckx Rudi A. J. O. , Borra Ronald J. H. , Lammertsma Adriaan A. , Glaudemans Andor W. J. M. , Slart Riemer H. J. A. , Yaqub Maqsood , Tsoumpas Charalampos , Boellaard Ronald
Published: October 2022

Background

Excellent performance characteristics of the Vision Quadra PET/CT, e.g. a substantial increase in sensitivity, allow for precise measurements of image-derived input functions (IDIF) and tissue time activity curves. Previously we have proposed a method for a reduced 30 min (as opposed to 60 min) whole body 18F-FDG Patlak PET imaging procedure using a previously published population-averaged input function (PIF) scaled to IDIF values at 30–60 min post-injection (p.i.). The aim of the present study was to apply this method using the Vision Quadra PET/CT, including the use of a PIF to allow for shortened scan durations.

Methods

Twelve patients with suspected lung malignancy were included and received a weight-based injection of 18F-FDG. Patients underwent a 65-min dynamic PET acquisition which were reconstructed using European Association of Nuclear Medicine Research Ltd. (EARL) standards 2 reconstruction settings. A volume of interest (VOI) was placed in the ascending aorta (AA) to obtain the IDIF. An external PIF was scaled to IDIF values at 30–60, 40–60, and 50–60 min p.i., respectively, and parametric 18F-FDG influx rate constant (Ki) images were generated using a t* of 30, 40 or 50 min, respectively. Herein, tumour lesions as well as healthy tissues, i.e. liver, muscle tissue, spleen and grey matter, were segmented.

Results

Good agreement between the IDIF and corresponding PIF scaled to 30–60 min p.i. and 40–60 min p.i. was obtained with 7.38% deviation in Ki. Bland–Altman plots showed excellent agreement in Ki obtained using the PIF scaled to the IDIF at 30–60 min p.i. and at 40–60 min p.i. as all data points were within the limits of agreement (LOA) (− 0.004–0.002, bias: − 0.001); for the 50–60 min p.i. Ki, all except one data point fell in between the LOA (− 0.021–0.012, bias: − 0.005).

Conclusions

Parametric whole body 18F-FDG Patlak Ki images can be generated non-invasively on a Vision Quadra PET/CT system. In addition, using a scaled PIF allows for a substantial (factor 2 to 3) reduction in scan time without substantial loss of accuracy (7.38% bias) and precision (image quality and noise interference).
Clinical Outcome Following Concussion Among College Athletes with a History of Prior Concussion: A Systematic Review
Authors: Gaudet Charles E. , Iverson Grant L. , Kissinger-Knox Alicia , Van Patten Ryan , Cook Nathan E.
Published: October 2022

Background

There is long-standing interest in, and concern about, whether collegiate athletes with a history of concussion will experience worse clinical outcomes, or prolonged recovery, should they sustain a subsequent concussion.

Objectives

This systematic review examined the association between prior concussion history and clinical outcomes following a subsequent sport-related concussion among college-age student athletes.

Study Design

Systematic review.

Methods

We screened 5,118 abstracts and 619 full-text articles that were appraised to determine whether they met inclusion criteria. We utilized a likelihood heuristic to assess the probability of observing a specific number of statistically significant and nonsignificant studies reporting an association between concussion history and clinical outcomes. We conducted a narrative synthesis of the study findings.

Results

Sixteen studies met the inclusion criteria. Thirteen studies reported the number of participants with a history of prior concussions (≥ 1), which totaled 1690 of 4573 total participants (on average 37.0% of study participants; median = 46.0%, range 5.6–63.8%). On the Newcastle–Ottawa Quality Assessment Scale, the risk of bias ratings ranged from 3 to 9 (mean = 5.4, SD = 1.4). Across all studies, 43.8% (k = 7/16) reported at least one statistically significant result among primary analyses showing an association between concussion history and worse clinical outcome. A minority of studies reporting on symptom duration (4/13, 30.8%) and time to return to play (2/7, 28.6%) found an association between concussion history and worse outcome. Studies included in the review reported limited information pertaining to the characteristics of prior concussions, such as presence or duration of loss of consciousness or posttraumatic amnesia, age at first lifetime concussion, time since most recent past concussion, or length of recovery from prior concussions.

Conclusion

The question of whether college athletes with a prior history of concussion have worse clinical outcome from their next sport-related concussion remains unresolved. The published results are mixed and in aggregate show modest evidence for an association. Many studies have small samples, and only three studies were designed specifically to address this research question. Important outcomes, such as time to return to academics, have not been adequately studied. Larger hypothesis-driven studies considering the number of prior concussions (e.g., 3 or more) are needed.

Trial registration: PROSPERO CRD42016041479, CRD42019128300.
Failed spinal anesthesia due to accidental dural puncture: a case report
Authors: Honda Jun , Yamazaki Yuki , Yakushiji Tatsumi , Hirata Hinako , Inoue Satoki
Published: October 2022

Background

We present a case of inadequate spinal anesthesia possibly due to cerebrospinal fluid (CSF) leakage into the epidural space caused by accidental dural puncture (ADP).

Case presentation

A 28-year-old woman with twin pregnancy underwent a cesarean section. She was scheduled to undergo combined spinal-epidural anesthesia (CSEA). Hyperbaric bupivacaine 9 mg with fentanyl 15 μg, with an additional bupivacaine 5 mg was administered from the L3/4 interspace for spinal anesthesia after repeated ADP at T12/L1; however, analgesia level was only up to T12. Insufficient analgesia level would be attributed to leakage of bupivacaine into the epidural space with the CSF via the injured dura. Planned surgery was performed under general anesthesia and completed uneventfully.

Conclusion

In spinal anesthesia performed after ADP in pregnant women, the anesthesia level may not increase as expected if there is a large amount of CSF leakage.
“We start where we are”: a qualitative study of barriers and pragmatic solutions to the assessment and reporting of implementation strategy fidelity
Authors: Akiba Christopher F. , Powell Byron J. , Pence Brian W. , Muessig Kate , Golin Carol E. , Go Vivian
Published: October 2022

Background

Fidelity measurement of implementation strategies is underdeveloped and underreported, and the level of reporting is decreasing over time. Failing to properly measure the factors that affect the delivery of an implementation strategy may obscure the link between a strategy and its outcomes. Barriers to assessing and reporting implementation strategy fidelity among researchers are not well understood. The aims of this qualitative study were to identify barriers to fidelity measurement and pragmatic pathways towards improvement.

Methods

We conducted in-depth interviews among researchers conducting implementation trials. We utilized a theory-informed interview approach to elicit the barriers and possible solutions to implementation strategy fidelity assessment and reporting. Reflexive-thematic analysis guided coding and memo-writing to determine key themes regarding barriers and solutions.

Results

Twenty-two implementation researchers were interviewed. Participants agreed that implementation strategy fidelity was an essential element of implementation trials and that its assessment and reporting should improve. Key thematic barriers focused on (1) a current lack of validated fidelity tools with the need to assess fidelity in the short term, (2) the complex nature of some implementation strategies, (3) conceptual complications when assessing fidelity within mechanisms-focused implementation research, and (4) structural issues related to funding and publishing. Researchers also suggested pragmatic solutions to overcome each barrier. Respondents reported using specification and tracking data in the short term until validated tools become available. Participants suggested that researchers with strategy-specific content expertise lead the way in identifying core components and setting fidelity requirements for them. Addressing the third barrier, participants provided examples of what pragmatic prospective and retrospective fidelity assessments might look like along a mechanistic pathway. Finally, researchers described approaches to minimize costs of data collection, as well as more structural accountability like adopting and enforcing reporting guidelines or changing the structure of funding opportunities.

Discussion

We propose short- and long-term priorities for improving the assessment and reporting of implementation strategy fidelity and the quality of implementation research.

Conclusions

A better understanding of the barriers to implementation strategy fidelity assessment may pave the way towards pragmatic solutions.
Partial nasal bone reconstruction with acrylic bone cement: experimental study
Authors: Karataş Halil Altın , Karakoç Ömer , Ocal F. Ceyda Akın , Bınar Murat , Kılınç Melih
Published: October 2022

Background

The aim of this study was to evaluate the effectiveness of acrylic bone cement in partial nasal bone reconstruction.

Methods

This study was conducted using nine New Zealand rabbits. The left nasal bones of the rabbits were included in the experimental group, and the right nasal bones were evaluated as the control group. The partial bone segments on the bilateral nasal bones were marked and removed symmetrically. A synthetic graft material made of acrylic bone cement was placed in experimental group, and the partial bone segment removed from the right side was placed in control group as an autograft. All rabbits were sacrificed at the end of the 28th day. Samples were taken from the grafts and from the surrounding soft tissues for histopathological examination. Acute inflammation, chronic inflammation, vascularization, fibrosis, foreign body reaction, bone proliferation, and the presence of empty lacunae were evaluated under a light microscope for both groups.

Results

Surrounding soft tissue on synthetic and autograft were the same in terms of chronic inflammation. There was no statistically significant difference for vascularization, fibrosis, and foreign body reaction. Synthetic graft and autograft were the same in terms of chronic inflammation, fibrosis, and bone proliferation. There was no statistically significant difference for vascularization, foreign body reaction, and presence of empty lacunae (p > 0.05).

Conclusion

This study showed no significant differences between the use of acrylic bone and the use of an autograft for partial nasal bone reconstruction in terms of graft or tissue healing. Acrylic bone cement may therefore serve as a good alternative for nasal bone reconstruction.
Is Routine Omentectomy a Necessary Component of Cytoreductive Surgery and HIPEC?
Authors: Khan Sohini , Doan Nguyen-Huong , Hosseini Mojgan , Kelly Kaitlyn , Veerapong Jula , Lowy Andrew M. , Baumgartner Joel
Published: October 2022

Background

Cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases traditionally includes omentectomy, even in the absence of visible omental metastases. We sought to determine the rate of occult histologic omental metastasis (OHOM), evaluate morbidity with omentectomy, and examine the rate of omental recurrence among patients undergoing CRS-HIPEC.

Methods

All CRS-HIPEC procedures from August 2007 to August 2020 were included in this single-center, retrospective, cohort study. Procedures were divided into those that included greater omentectomy (OM) and those that did not (NOM). The incidence of OHOM was evaluated specifically among the OM group with a grossly normal omentum. Multivariate regression analyses were performed to evaluate return of bowel function, ileus, and morbidity in the OM and NOM groups.

Results

Among 683 CRS-HIPEC procedures, 578 (84.6%) included omentectomy and 105 (15.4%) did not. The OM group had higher operative time, blood loss, peritoneal cancer index, number of visceral resections, and length of stay. In the OM group, 72 (12.5%) patients had a grossly normal omentum, and 23 (31.9%) of these had OHOM. Risk-adjusted return of bowel function, ileus, and 60-day complications were no different in the OM and NOM groups. Among 43 patients with residual omentum, 24 (55.8%) recurred, including 9 (20.9%) with omental recurrence.

Conclusions

Histologically occult metastasis was present in one-third of patients undergoing omentectomy during CRS-HIPEC. Omentectomy did not increase the rate of overall morbidity, and one-fifth of patients with residual omentum later developed omental recurrence. Thus, omentectomy is warranted in the absence of gross metastases during CRS-HIPEC.
Legal and organizational aspects of the implementation of immunization in Poland after the COVID-19 pandemic
Authors: Kowalcze Karolina , Wolnowska Monika , Musiałowska Karolina , Staśkiewicz Wiktoria , Białek-Dratwa Agnieszka , Krysiak Robert , Stencel-Gabriel Krystyna
Published: October 2022

Introduction. Reducing the transmission of infectious diseases both among vaccinated individuals and the general population is only possible with the introduction of mandatory vaccination. The purpose of this article is to analyze the normative acts in force in the territory of the Republic of Poland, regulating mandatory and recommended immunizations. State of the art description. In Poland, immunization is mandatory and carried out in accordance with the Immunization Program for children and adolescents up to the age of 19, and persons particularly vulnerable to disease are published annually as a communiqué of the Chief Sanitary Inspector in the Official Journal of the Minister of Health. The issue of recommended immunizations is clarified by the Regulation of the Minister of Health of September 16, 2010, on the list of recommended immunizations and how to finance and document recommended immunizations required by international health regulations. According to Article 17(6) of the Law, vaccination may be performed by a doctor, feldsher, nurse, midwife, and school hygienist, as long as they have the appropriate qualifications. These qualifications are described in detail in the Ordinance of the Minister of Health of August 18, 2011, on mandatory immunization. According to Article 16 of the Law on Patient Rights and Patient Ombudsman, every patient has the right both to consent and to refuse certain health services. Conclusion. Immunization on the territory of the Republic of Poland is mandatory and is subject to legal regulation in the form of laws, regulations, and announcements, cited above. The exceptions are recommended vaccinations and COVID-19 vaccination, which are voluntary but are also legally normalized.
Barriers to and attitudes towards the use of safety engineered devices for paediatric cannulation in emergency care
Authors: Martinez Rachel
Published: October 2022

This article describes a report of the attitudes towards and barriers to the use of safety cannulas in paediatric patients. The evaluation was prompted by a lack of engagement from both doctors and nurses who continued to use non-safety-engineered devices (non-SEDs) after safety-engineered devices (SEDs) were introduced into a paediatric emergency department (ED). A survey was conducted among doctors and nurses working in the paediatric ED with questions focusing on the participants' clinical experience, views on safety, access to training and device preference, providing both quantitative and qualitative data. The findings highlighted several issues, including a difference in opinion between professional groups towards safe sharps. Significant differences in access to training and education between doctors and nurses were also identified; including those with up-to-date training appearing more likely to use a SED than those without. Recommendations including strategies for improving compliance have been proposed, with a plan to conduct a clinical audit to measure compliance at a later date.
The importance of security for the crypto industry
Authors: Wilczek Marc
Published: October 2022

Cyber attacks are becoming an increasingly important issue in the financial industry. The recent shutdown of the darknet marketplace ‘Hydra Markets’ in April 2022, firmly established cyberthreats as a critical topic within the world of finance. Hydra was a platform that had generated a revenue of €1.2bn by 2020 from illegal business on the Internet. So how strongly is the sensitive environment of the crypto industry affected by cyber attacks, especially DDoS?
"LUZ E SAPATOS" : O ENSINO INCLUSIVO À LUZ DOS "SAPATOS DO PAI"
Authors: Sales da Silva Beatriz
Published: October 2022

A proposição deste artigo objetivo-subjetivo propõe-se a argumentar que o ensino inclusivo não se restringe às paredes da escola. Adentra à literatura infantojuvenil. Para tanto, conforme D’Angelis, em vez de “que escola queremos?”, vamos além e partimos da premissa do “educador@ que precisamos”. Tudo começa no educador, na sua disposição de aprender o “ofício de sapateiro”, acolhendo os pés descalços das infâncias e juventudes, incluindo nesse processo o dele também. A arte de fabricar sapatos passa pela pedagogia da contação de histórias, do teatro, da arte – como se apresenta neste artigo. Incluir a todos, sem distinção, e perceber que os “guetos” não incluem ninguém, são traiçoeiros. O texto convida @ leitor@ a andar entre livros e considerar o ensino inclusivo!
EDUCAÇÃO INCLUSIVA E PRÁTICA PEDAGÓGICA: PROPOSIÇÕES DE UMA PESQUISA INSTITUCIONAL
Authors: Speglich de Amorim Carrico Janaina , Rebeca Ramos Campos de Oliveira  , Adele Guimaraes Ubarana Santos
Published: October 2022

O presente artigo apresenta uma pesquisa institucional, desenvolvida no Núcleo de Educação da Infância da Universidade Federal do Rio Grande do Norte, NEI-CAp/UFRN. O referido trabalho tem um caráter propositivo, no que diz respeito às possibilidades de construção de práticas pedagógicas inclusivas. A investigação está sendo desenvolvida em um contexto de colaboração entre pares, no caso, entre os professores e as professoras de uma instituição que dialogam acerca de seus fazeres pedagógicos voltados ao atendimento a todas as crianças. Almeja-se mapear os processos colaborativos vividos por professores e professoras da instituição, entrelaçados no cotidiano da escola básica, ao buscarem a qualificação do próprio trabalho pedagógico inclusivo. A partir do estudo desses processos colaborativos entre os profissionais, se pretende construir uma cartografia de ações, estratégias e posicionamentos dos professores e professoras, no que diz respeito à constituição de parcerias de trabalho voltadas às práticas pedagógicas inclusivas.
SENTINDO O CAMINHO COM OS ACADÊMICOS CEGOS: UMA PESQUISA PLURAL SOBRE AS LINGUAGENS INVISIBILIZADAS
Authors: Colman Martins Simone de Fatima
Published: October 2022

Este artigo apresenta o relato de experiências vivenciadas por uma professora que se descobriu pesquisadora. As experiências aconteceram no decorrer de uma pesquisa de doutorado, a qual visou analisar o contexto das produções textuais na perspectiva de acadêmicos cegos ou com baixa visão da Associação de Pais e Amigos do Deficiente Visual em Ponta Grossa, doravante APADEVI/PG. Ao todo, o estudo contou com a participação de treze estudantes e a pesquisa qualitativa, com abordagem narrativa gerou dados através de: dez entrevistas de grupo focal, nove entrevistas individuais semiestruturadas, anotações de campo e vivências decorridas do estudo. Os relatos apresentados buscam ampliar o conhecimento sobre a realidade vivenciada diariamente pelos acadêmicos cegos/baixa visão e levam a reflexões sobre o quanto os videntes não entendem e não valorizam as experiências sensoriais e por consequência as Linguagens Sensoriais que são invisibilizadas por toda a sociedade.
A NECESSÁRIA RUPTURA COM O DIAGNÓSTICO MÉDICO NA ESCOLA PARA TODOS
Authors: Costa Renders Elizabete Cristina , De Lyra Luciana
Published: October 2022

Este artigo apresenta resultados de uma pesquisa que se pautou na questão: como uma sondagem pedagógica, baseada nos princípios do Design Universal para Aprendizagem (DUA), pode contribuir para a prática do professor, de forma que ele possa conhecer seus alunos, sem ficar fadado ao diagnóstico médico? Definiram-se como objetivos específicos: analisar o papel do professor e a importância do seu saber no contexto educacional, ponderando sobre as contribuições do diagnóstico para a prática pedagógica; verificar como a sondagem pedagógica pode contribuir para o planejamento das práticas educativas inclusivas e elaborar um instrumento de sondagem pedagógica baseado no DUA. O estudo contou com a participação de professoras que tiveram alunos encaminhados para avaliação interdisciplinar. Utilizou-se entrevista individual e rodas de conversa, oportunizando a escuta das professoras. Os resultados apontaram a necessidade de a escola afirmar seu papel pedagógico, validando o saber do professor por meio de abordagem curricular acessível. Insere-se no âmbito do projeto regular N. 2017/20862-8, FAPESP.
APRESENTAÇÃO
Authors: Costa Renders Elizabete Cristina , Egler Mantoan Maria Tereza
Published: October 2022

Apresentação do dossiê pelas organizadoras
Turning the political into ideology: The exorcizing of a metaphor in James Blish’s short story adaptation of a cold war Star Trek narrative
Authors: Urbańczyk Agnieszka
Published: October 2022

The article is a case study of James Blish’s short story adaptation of the Star Trek: The Original Series (TOS) episode ‘Balance of Terror’, originally a pacifist narrative focused on tragic choices forced upon individuals. The episode is notable not only for introducing Romulans to the franchise but also for painting them in an unexpectedly sympathetic light as the extratextual power struggle between the United States and the Soviet Union is criticized by means of cognitive estrangement. The hegemonic tenor of the submarine film subgenre the episode emulates becomes quickly subverted as both sides of the conflict are given a voice, and the eventual victory of Captain Kirk is painted almost as a moral defeat. Blish’s adaptation is a testimony to the misinterpretation of TOS. Blish did not translate an SF story into another medium but rewrote it into a war narrative while not changing any major events, taking the episode at face value and apparently not noticing the allegory on which it was founded. This case serves as an example of how easily a subversive narrative can be co-opted the moment genre is misidentified.
Nationalism or patriotism? The rhetorical genesis of a false dilemma
Authors: Ribeiro Henrique Jales
Published: October 2022

Starting from a recent ideological and political controversy regarding the devaluation of the concept of “nationalism” in relation to that of ‘patriotism”, the author – following his own years-long investigations on the subject – historically and philosophically reframes each of these concepts from the perspective of rhetoric and argumentation. It is shown, in this context, that the arguments in question are fallacious (and even, in some applications, clearly perverse) and a radical and provocative reformulation of the aforementioned concepts and the controversy involved is proposed – a reformulation which, eventually and at best, may give rise to a new historiography on the subject.
The Coimbra Jesuit Course in 18th-19th century Russia
Authors: Nikitenko Yulia
Published: October 2022

This article is aimed at examining the impact of Jesuit philosophical education, particularly the Cursus Conimbricensis, on the intellectual culture existing during the 18th and 19th centuries in the Slavic territories now part of Belarus, Russia, and Ukraine. We have sought to trace the movement of Coimbra Aristotelianism to the East and discern the most promising directions for further research. Although any direct references to the Coimbra Course made by Russian-speaking intellectuals of the period are hard to find, we propose an examination of the circulation and provenance of the actual volumes as a means of establishing the link between Slavic thought and Coimbra Jesuit Aristotelianism.
Forgetting the tragic
Authors: Roullière Yves
Published: October 2022

What Emmanuel Falque seems to achieve in this book is to make the "out of phenomenon" synonymous with the "tragic". Certainly, we see the heuristic interest in creating and cultivating the concept of "out of phenomenon". In Aeschylus' Agamemnon (a reference that runs throughout this book), the atrocious rubs shoulders with the filthy and can only test us, traumatize us, and, therefore, can only "modify" us in some way. If it is also true that the tragic, according to Kierkegaard in particular, can lead to despair, another attitude seems to be dodged and no less sketched by Falque, namely, under the influence of Nietzsche this time, the amor fati: "Learned in the War School of life: what does not kill me strengthens me." Falque does not refer to it explicitly, while the approach that consists in looking the trauma in the face, in having no fear of fixing it, of penetrating it, of inhabiting it, appears to stem from this love of fatum, of destiny "that falls on us", enough in any case for us to be modified in a sense as unexpected as irreparable. But isn't it also the definition and very role of tragic and/or catastrophic feelings?
Investigation of Bacterial Persistence and Filaments Formation in Clinical Klebsiella pneumoniae
Authors: Aziz Sarah N. , Al Marjani Mohammed F.
Published: October 2022

Bacterial persistence is recognized as a major cause of antibiotic therapy failure, causing biofilms, and chronic intractable infections. The emergence of persisters in Klebsiella pneumoniae isolates has become a worldwide public health concern. The goal of the present study is to investigate the formation of persister cells beside filaments in Iraqi K. pneumoniae isolates. A total of fifty clinical K. pneumoniae isolates were collected from different clinical specimens and identified using the genotypic identification by using specific primer (rpoB gene) from housekeeping genes. Persister cells investigation is performed by exposure of stationary phase K. pneumoniae isolates to a high concentration of ciprofloxacin (×10 MIC) and counting the number of viable persister cells by CFU counts. Bacterial filament formation is detected and measured by light microscope scanning electron microscope. The results show the  bility of these pathogenic bacteria to form persister cells to survive the bactericidal antibiotics and to cause chronic infection.Furthermore, persistent isolates have the ability to change in shape and size extensively, about 4 times increase in cell length than their normal length. These phenomena are possibly the initial stages of bacterial resistance prevalence.
Centering Love as the Foundation of a Racially Just and Decolonizing Student Affairs
Authors: Squire Dian , Blansett Rachael , Wright-Mair Raquel
Published: October 2022

In writings on humanizing pedagogy, the concept of love is often presented as the core principle grounding all action. However, love, as it is currently conceptualized, leaves much room for interpretation (hooks, 2000; Levinas, 1998; Matias & Allen, 2013). Therefore, it is critical as educators and Student Affairs professionals we challenge the idea of how we commonly think about love as an abstract notion (“fight hate with love”) and, rather, reimagine what love means within a movement that challenges oppressive structures within Student Affairs. By not recognizing or taking actions to correct higher education’s past acts of indifference (noting the gross injustices against Indigenous populations and the exploited labor and enslavement of Africans rooted within the history of college campuses), we are perpetuating the protection of a historical lie and continuing the legacy of settler colonialism and dehumanization within the profession. In this manuscript, we provide an overview of settler colonialism and its impact in Student Affairs, review how love is academically and culturally defined across fields, and present an alternative framework for building love as an actionable "skill set" that allows educators to move the field toward racial justice and humanization.
Análisis morfológicos y moleculares respaldan la identidad de Arenaria pycnophylloides (Caryophyllaceae, Arenarieae) y la exclusión del género Sabulina para la Flora Argentina
Authors: Zanotti Christian A. , Chiarini Franco E. , von Mering Sabine , Acosta Juan M.
Published: October 2022

Minuartia altoandina has been described as an endemic species for northwestern Argentina, and later transferred to the genus Sabulina. In this contribution and based on morphological observations and molecular data, Sabulina altoandina is proposed here as a heterotypic synonym of Arenaria pycnophylloides, a native species to the high Andean regions of Bolivia and northwestern Argentina; as a consequence, the genus Sabulina is excluded from the Argentinian Flora. On the other hand, A. pycnophylloides var. compacta is synonymized under A. pycnophylloides, and in addition, the name of this variety is lectotypified. A morphological description of A. pycnophylloides and a photographic plate of the taxon are provided to facilitate identification of the species. Additionally, a distribution map of the species is provided and is excluded from the Peruvian Flora.