bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparaison de diverses préparations industrielles de bactéries lactiques réactivees pour stimuler la fermentation malolactique
Authors: Joyeux Annick , Lonvaud-Funel Aline
Published: September 2016

La réactivation préalable des bactéries lactiques est indispensable avant l'inoculation des vins. Le mode opératoire est précisé : le milieu optimum est à base de jus de raisin.

Différentes préparations industrielles ont été testées au laboratoire. Celles de Leuconostoc œnos ont donné de bons résultats. L'une d'entre elles a été utilisée dans la pratique au cours des deux dernières campagnes de vinification. Les succès obtenus, surtout en 1984 dans des cas particulièrement difficiles montrent bien l'efficacité de ce procédé pour le déclenchement de la fermentation malolactique.

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The previous reactivation of lactic acid bacteria is essential before the inoculation of the wine. The method is specified: the optimium media is made with grape must.

Several industrial preparations of bacteria were tried; those constituted with Leuconostoc oenos gave good results. One of them was utilized in practice during the two last vinification campaigns. The success obtained, especially in 1984 in particular difficult cases give proof of the efficiency of this process to start the malolactic fermentation.
Etude comparée de dix-huit plaques filtrantes de différentes origines
Authors: Serrano Michel , Pricart Jean-Philippe , Ribéreau-Gayon Pascal
Published: September 2016

Les auteurs montrent que la préparation industrielle des vins en vue de l'embouteillage par filtration sur précouche de diatomées est aujourd'hui supérieure à ce qu'elle était il y a une dizaine d'années.

Ils comparent ensuite au laboratoire, sous une pression constante de 0,5 bar, dix-huit plaques filtrantes de neuf fabricants. Les résultats montrent que toutes les plaques permettent d'obtenir des débits supérieurs à ceux recommandés par les fabricants. L'utilisation des plaques testées diminuent de façon notable les indices de colmatage des vins. Six des neuf fabrications assurent une qualité de filtration tout à fait satisfaisante ; les autres sont moins efficaces.

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Today the preparation of wines for bottling by filtration with kieselguhr is of superior quality than it was about ten years ago.

Eighteen sheets from nine manufactors were compared, under a constant pressure of 0.5 bar, at the laboratory. The results showed that for all the sheets the flow rate may be higher than those of the manufactors. The use of the tested sheets decreases notably the wine blocking index. Six from the nine manufactures ensured a satisfying filtration quality; the others were less effective.
Prevalence of overweihgt, obesity, abdominal-obesity and short stature of adult population of Rosario, Argentina
Authors: Zapata María Elisa
Published: September 2016

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Intra-Articular Cellular Therapy for Osteoarthritis and Focal Cartilage Defects of the Knee
Authors: Chahla Jorge , Piuzzi Nicolas S. , Mitchell Justin J. , Dean Chase S. , Pascual-Garrido Cecilia , LaPrade Robert F. , Muschler George F.
Published: September 2016

Background:

Intra-articular cellular therapy injections constitute an appealing strategy that may modify the intra-articular milieu or regenerate cartilage in the settings of osteoarthritis and focal cartilage defects. However, little consensus exists regarding the indications for cellular therapies, optimal cell sources, methods of preparation and delivery, or means by which outcomes should be reported.

Methods:

We present a systematic review of the current literature regarding the safety and efficacy of cellular therapy delivered by intra-articular injection in the knee that provided a Level of Evidence of III or higher. A total of 420 papers were screened. Methodological quality was assessed using a modified Coleman methodology score.

Results:

Only 6 studies (4 Level II and 2 Level III) met the criteria to be included in this review; 3 studies were on treatment of osteoarthritis and 3 were on treatment of focal cartilage defects. These included 4 randomized controlled studies without blinding, 1 prospective cohort study, and 1 retrospective therapeutic case-control study. The studies varied widely with respect to cell sources, cell characterization, adjuvant therapies, and assessment of outcomes. Outcome was reported in a total of 300 knees (124 in the osteoarthritis studies and 176 in the cartilage defect studies). Mean follow-up was 21.0 months (range, 12 to 36 months). All studies reported improved outcomes with intra-articular cellular therapy and no major adverse events. The mean modified Coleman methodology score was 59.1 ± 16 (range, 32 to 82).

Conclusions:

The studies of intra-articular cellular therapy injections for osteoarthritis and focal cartilage defects in the human knee suggested positive results with respect to clinical improvement and safety. However, the improvement was modest and a placebo effect cannot be disregarded. The overall quality of the literature was poor, and the methodological quality was fair, even among Level-II and III studies. Effective clinical assessment and optimization of injection therapies will demand greater attention to study methodology, including blinding; standardized quantitative methods for cell harvesting, processing, characterization, and delivery; and standardized reporting of clinical and structural outcomes.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Return to Work and Sport Following High Tibial Osteotomy
Authors: Ekhtiari Seper , Haldane Chloe E. , de SA Darren , Simunovic Nicole , Musahl Volker , Ayeni Olufemi R.
Published: September 2016

Background:

The purpose of this study was to examine (1) timelines for return to sport and work following high tibial osteotomy (HTO), and (2) whether patients return to sport and work at levels similar to preoperative levels.

Methods:

A systematic search was conducted across 3 databases (MEDLINE, Embase, and PubMed). Two reviewers independently screened the results for relevant articles. Data regarding patient demographics, indications, surgical technique, return to work and sport, and complication and failure rates were abstracted from eligible studies.

Results:

Nineteen studies were included, involving 1,189 patients (64% male, 21% female, 15% unspecified) and 1,224 knees. Mean age was 46.2 years (range, 16 to 80 years). Opening-wedge HTO was most commonly used, followed by closing-wedge HTO and hemicallotasis. Mean follow-up was 65.4 months (range, 8 to 253 months). Overall, 87.2% of patients returned to sport postoperatively, and 78.6% returned at an equal or greater level. Among competitive athletes, 54% returned to competition. Overall, 84.5% of patients returned to work postoperatively, and 65.5% returned at an equal or greater level. Approximately 90% of patients who returned to work or sport did so within 1 year. The complication rate was 5.8%, with infection being the most common complication; 7.0% of patients progressed to a total knee arthroplasty at a mean of 6.7 years (range, 0.8 to 15 years) following HTO.

Conclusions:

The majority of patients undergoing HTO return to sport and work, and most return within 1 year of the operation. Most patients return to sport at a level equal to or greater than the preoperative level. Approximately two-thirds of patients return to an equal or greater level of physical work.

Level of Evidence:

TherapeuticLevel IV. See Instructions for Authors for a complete description of levels of evidence.
Existence of Severe Slugging in Toe-Up Horizontal Gas Wells
Authors: Brito R.. , Pereyra E.. , Sarica C..
Published: September 2016

A systematic experimental study on two-phase air-water was carried out to evaluate the existence of severe slugging in toe-up gas wells. Experiments were conducted in a facility with a 2-in. ID and 62.6-ft. long lateral section and a 41-ft. vertical section. The lateral section was inclined −1° with respect to the horizontal to mimic a toe-up well. In addition, different flow conditions were considered to simulate the well production as the reservoir pressure depletes. The existence of severe slugging was evaluated by measuring pressure fluctuations and visual flow observation. Moreover, transient simulations in OLGA were performed to evaluate the possibility of severe slugging in toe-up gas wells. Experimentally, severe slugging was observed for the toe-up configuration and extremely low gas flow rates. Under this condition, significant fluctuations in pressure, gas and liquid flow rates are observed. However, experimental results did not conclude with certainty whether the severe slugging phenomenon can occur in a real gas well.
Design of Plunger Lift for Gas Wells
Authors: Hashmi G. M. , Hasan A. R. , Kabir C. S.
Published: September 2016

Liquid loading has been an issue for mature gas wells due to declining reservoir energy. In mature fields, one of the methods used to mitigate this problem is plunger lift. However, the design of plunger lift may still question the premise of optimization. This paper presents a new model for the design of plunger lift for wells in gas reservoirs with significant water production. The proposed model allows for an efficient design of plunger lift by incorporating physics of fluid flow in the wellbore.

The wellbore/reservoir model presupposes presence of some liquid in the tubing and in the tubing/casing annulus, but most of the tubing and annular space is assumed to be filled with gas. Closure of the tubinghead valve initiates recuperation of reservoir energy, thereby allowing fluid influx to occur in the tubing and annulus. Eventually, accumulation of sufficient pressurized gas in the annulus lifts the plunger along with the liquid and gas on top of it. The model accounts for the pressure-volume (pV) work done by the pressurized gas in the annulus, including the energy needed to lift the liquid and gas on top of the plunger, and friction during the plunger movement. Because the dimensions and trajectory of the wellbore have such profound impact on the operability of plunger lift, operators can use this model by just providing the known input parameters to determine the design variables, target casing pressure and duration for the plunger cycle.
A Novel Analysis to Detect When and Where Liquid Loading Occurs in Horizontal Gas Wells - Case Studies
Authors: Brito R.. , Pereyra E.. , Sarica C..
Published: September 2016

This paper presents the development, validation, and application of a novel methodology to detect when and where liquid loading occurs in horizontal gas wells. Proposed liquid loading onset model is based on two possible mechanisms, namely, liquid film reversal (Barnea 1986) and liquid wave growth (Taitel 1976). Additionally, the liquid entrainment in the gas core and the effect of deviation angle on the liquid distribution along the pipe circumference were considered (Brito 2015). Furthermore, a liquid loading onset detection methodology and software were developed to predict the critical gas velocity along the well trajectory as function of the expected gas and liquid production decline. This facilitates the determination of the time and location (when and where) liquid loading starts and what gas flow rates are required to avoid liquid accumulation at different points along the well. Several case studies, based on data from actual gas wells, are presented to demonstrate the proposed methodology applicability for determining effect of well trajectory, completion, liquid flow rate, operating conditions, and tubing location on liquid loading along the well.
Artificial Lift System for Horizontal Wells and Other Wells with Problematic Lift Conditions
Authors: Mazzanti Daryl , Dixon Danny
Published: September 2016

Artificial lift methods and devices have been a boon to the oil industry since the early days of the industry; however, conventional artificial lift that was designed to be placed in the vertical section is not adequate for wells with significant deviations from vertical. Placing rod pumps and other artificial lift methods in deviated sections are problematic resulting in high operating costs due to down hole failures, high back pressure on the reservoir, and poor liquid lift efficiencies due to gas interference in the down-hole pumps.

A new artificial lift method is presented herein that allows a rod pump, or other applicable pump, to be placed significantly above a deviated section while also providing lift for liquids located significantly below the pump. Additionally, the new method provides an improved down-hole gas separator which utilizes a packer type separator system that solves gas interference in wells that have small casing diameters, conventional tubing anchors, high liquid levels, or high gas to liquid ratios. Since reservoir fluids that may contain solids are introduced in the casing annulus above the packer, a specially designed device called a packer shield is installed above the packer to prevent solids from falling on top of the packer and subsequently sticking it in place. All versions of the new method contain a velocity string that extends below the rod pump to improve lift from below the pump to above the pump. One version, designed for wells with sufficient reservoir energy, uses only the velocity string to naturally lift liquids up the velocity string to the pump, while a second version provides relatively low pressure, low volume gas injection to assist in lifting liquids up the velocity string to the pump.
Field Trial of a Novel Self-Reciprocating Hydraulic Pump for Deliquification
Authors: Romer M. C. , Brown M.. , Ainsworth N.. , Rundberg O.. , Bolt D. J. , Bolt T.. , Tolman R. C.
Published: September 2016

A novel hydraulically-powered, Self-Reciprocating Valve Pump (SRVP) was piloted in a Western Colorado gas well for deliquification operations. The objective was to pump fluids from a deep gas well and later retrieve and redeploy the SRVP without a workover rig. This paper will describe the SRVP technology, areas of applicability, and pilot program, including the completion design, deployment/retrieval workovers, performance, teardowns, learnings, and future plans.

Gas production wells tend to load up with produced or condensed liquids that create an impediment to flow and reduce or stop gas production. Pumps are typically used when the reservoir pressure is too low for less intrusive artificial lift methods or when significant amounts of fluid must be removed. Pumps can suffer from reliability issues and considerable installation/deployment costs because a workover rig is typically required for intervention. Unfavorable producing conditions and tortuous wellbore trajectories further tend to decrease run lives. These issues can make economical hydrocarbon production impossible. The SRVP was developed to overcome these challenges.

The SRVP is installed downhole inside a concentric tubing string and is powered by injecting a high pressure fluid. The injected (power) fluid causes the SRVP to reciprocate, driving a piston pump to produce formation liquids and power fluid back to surface up the concentric string by production tubing annulus. Removal of the produced fluids decreases backpressure on the formation, enabling gas production up the casing. Because there is no mechanical linkage to surface for pump operation, the SRVP can be deployed in highly-deviated and/or small-diameter wells that standard artificial lift methods would struggle with. Additionally, the SRVP is designed to be pumped into and out of the well following initial installation, greatly reducing deployment costs.

Three industry-first SRVPs were installed consecutively in a concentric flush-joint tubing string and were powered with a compact surface pumping unit. The SRVP proved the ability to lift 20 to 40 BFPD net fluids up the concentric string by production tubing annulus from more than 12,000 ft vertical depth while gas was produced up the casing. The SRVP was retrieved and redeployed several times either hydraulically and/or with slickline. System design, operation, and performance were continuously improved through the duration of the pilot program. Run life steadily increased to 50+ days with the third installation.
A Methodology of End of Tubing EOT Location Optimization for Horizontal Shale Gas Wells with and without Deliquification
Authors: Dinata Randy Chandrana , Sarica Cem , Pereyra Eduardo
Published: September 2016

Methodologies to predict the optimum End of Tubing (EOT) location with and without artificial lift using steady-state simulation approach are proposed. The optimum EOT location methodology without artificial lift is validated with 2-in. flow loop data and applied to synthetic field-scale cases. This methodology postulates the minimum Δptotal, defined as the difference between toe and wellhead pressure, should determine the optimum EOT location. The methodology is extended to incorporate reservoir coupling and liquid loading analysis to produce a more comprehensive EOT analysis. Liquid loading evaluation is necessary as the optimum EOT methodology may not indicate the liquid loading potential in the well. In the case where reservoir potential is integrated into the methodology, maximizing the well's gas flow rates is used as the optimization criterion. The modification of the methodology to determine the optimum EOT location with installed gas lift or Electrical Submersible Pump (ESP) system is demonstrated. Gas lift can be used to reduce the Δptotal or increase the in-situ gas velocity to avoid liquid loading. In ESP systems, EOT location plays a role in preventing gas lock from occurring in the ESP by utilizing the natural separation of liquid and gas at an appropriate EOT location.
Inhibition kinetics and granular sludge in an ANAMMOX reactor treating mature landfill leachate
Authors: Yun Li , Zhaoming Zheng , Jun Li , Baihang Zhao , Wei Bian , Yanzhuo Zhang , Xiujie Wang
Published: September 2016

The present study reports the inhibition kinetics and granular sludge in an anaerobic ammonium oxidation (ANAMMOX) – up-flow anaerobic sludge blanket reactor fed with diluted mature landfill leachate. The activity of ANAMMOX bacteria was inhibited by addition of mature landfill leachate, but gradually adapted to the leachate. The system achieved efficient nitrogen removal during 65–75 d and the average removal efficiencies for NH4+-N, NO2−-N and total nitrogen (TN) were 96%, 95% and 87%, respectively. ANAMMOX was the main pathway of nitrogen removal in the system, and heterotrophic denitrification occurred simultaneously. In addition, aerobic ammonia oxidation and aerobic nitrite oxidation were active in this system. Inhibition kinetic experiments showed that the NH4+-N and NO2−-N inhibition concentration threshold of ANAMMOX were 489.03 mg/L and 192.36 mg/L, respectively. ANAMMOX was significantly inhibited by mature landfill leachate, and was completely inhibited when the leachate concentration was 1,450.69 mg/L (calculated in chemical oxygen demand). Thus, the inhibition concentration of substrate and landfill leachate should be considered when applying the ANAMMOX process to landfill leachate. The color of granular sludge ANAMMOX changed from brick-red into a reddish-brown. The particle size increased from small to large, with evident granulation of the ANAMMOX sludge.
Abordagem analítica e computacional do teste drawdown
Authors: Garuzzi Ricardo Pessoti , Romero Oldrich Joel
Published: September 2016

Testes de pressão em poços de petróleo refere-se a uma técnica que visa determinar parâmetros do sistema poço/reservatório através da medição da pressão no fundo do poço e do fluxo em superfície. Os parâmetros a serem calculados/estimados são diversos, para exemplificar cita-se pressão inicial do reservatório, potencial de produção, permeabilidade, dano de formação, dentre outros. Quanto aos testes mais conhecidos tem-se o drawdown, buildup, flow-after flow, etc.. A técnica é fundamentada na solução transiente da equação da difusividade em meios porosos, desta forma procedimentos analíticos foram muito utilizados no passado recente, e ainda são, entretanto estão sendo aprimorados mediante desenvolvimento de softwares específicos que estão no centro da moderna metodologia e são, naturalmente, o caminho padrão de evolução. Nesse contexto, o objetivo principal desse trabalho é a comparação dos resultados obtidos utilizando o software F.A.S.T. WellTestTM, com os obtidos pelo modelo analítico de Lee (1984). O software utiliza técnicas consagradas na literatura para interpretar e obter informações importantes da formação produtora, enquanto que o trabalho do Professor Lee é referência na área de teste de poços. Será aplicada o método da derivada da pressão de Bourdet na análise do teste drawdown determinando assim a permeabilidade e o fator de película do sistema poço/reservatório.
Flow Characteristics of a Low Reynolds Number Jet in Crossflow with an Obstacle Block
Authors: Chang Jianlong , Shao Xudong , Hu Xiao , Zhang Shuangbiao
Published: September 2016

The jet in crossflow at very low Reynolds number (Re=100) with and without block is performed by means of large eddy simulation for the jet-to-crossflow velocity ratios (r) ranging from 1 to 3, and the corresponding flow characteristics are compared. The results show that the time-averaged particle trajectories of the jet are slightly changed if a block is presented, and the mixed vortices are weakened. The existence of the block also can accelerate the formation of stable counter-rotating vortex pair. At lower velocity ratio (r=1), the block has little effect on the jet in crossflow with a symmetrically positive and negative kidney shaped vortices. As the velocity ratio increases, the effect of block not only can generate an asymmetry of positive and negative kidney shaped vortices, but also it can reinforce the interaction between the positive and negative vortices in the jet in crossflow. The effect of block on the temperature field is also analyzed in detail.
Кальцифікація й апоптоз клітин крові як маркер наявності, тяжкості і прогресування ішемічної хвороби серця у поєднанні з цукровим діабетом 2-го типу: ультраструктурні та цитологічні дослідження
Authors: Kyiiak Yu.H. , Kohut M.A. , Andrushevska O. Yu. , Kohut L.M. , Kyiiak H. Yu. , Barnett O. Yu.
Published: September 2016

Актуальність. Збільшення внутрішньоклітинного вмісту Са2+ призводить до запуску процесів апоптозу і кальцифікації клітин крові та серцево-судинної системи. Тісний зв’язок між апоптозом клітин крові та їх кальцифікацією дає підстави вважати кальцій важливим маркером та ініціатором цього процесу. Мета роботи — дослідити ультраструктурні зміни та стан клітинного імунітету у пацієнтів з гострим коронарним синдромом (ГКС) і цукровим діабетом (ЦД) 2-го типу і виявити асоціацію між збільшенням внутрішньоклітинного кальцію в еритроцитах та кальцифікацією вінцевих артерій. Матеріали та методи. Обстежені 20 пацієнтів із ГКС у поєднанні з ЦД 2-го типу. Контрольну групу становили 10 осіб. Середній вік пацієнтів — 65,0 ± 5,6 року. Було проведено: мультиспіральну комп’ютерну томографію; цитологічне визначення солей кальцію в еритроцитах за методом Мак-Гі-Рассела; імунологічні дослідження апоптозу лейкоцитів за допомогою набору ApoLect; електронну мікроскопію для виявлення ультраструктурних ознак апоптозу клітин крові. Результати. У пацієнтів з високим і дуже високим індексом кальцифікації вінцевих артерій цитологічно спостерігається наявність в еритроцитах гранул кальцію різної величини і форми, фіолетово-синього забарвлення, анізо- та пойкілоцитоз еритроцитів; імунологічно — збільшення кількості апоптотично змінених і поява некротично змінених клітин крові; характерні також класичні ультраструктурні ознаки апоптозу лейкоцитів. Висновки. Наявність ГКС у пацієнтів із ЦД 2-го типу супроводжується активацією процесів апоптозу лейкоцитів, накопиченням іонів кальцію в еритроцитах, що асоціюється з високим і дуже високим індексом кальцифікації вінцевих артерій. Виявлення таких змін при дослідженні периферичної крові пацієнтів дає можливість вчасно запідозрити загрозу виникнення ішемічної хвороби серця й запобігти розвитку її тяжких ускладнень.
Аутоиммунные нарушения при эндокринной патологии. Новый взгляд на диагностику и менеджмент. По материалам 18th European Congress of Endocrinology (Munich, May 2016)
Authors: Komissarenko Yu.I. , Bobryk M.I.
Published: September 2016

В статье представлены актуальные данные о влиянии наличия аутоантител на тактику ведения аутоиммунных заболеваний: аутоиммунного тиреоидита, сахарного диабета, состояния носительства антитиреоидных и диабетассоциированных аутоантител, приведен алгоритм ведения беременных с наличием антител к тиреопероксидазе за 2016 год, подходы к оценке иммунного статуса у больных сахарным диабетом с наличием дефицита витамина D, описано влияние коррекции D-дефицита на иммунный статус при сочетанной эндокринной патологии.
У фокусі глімепірид: деякі аспекти використання оригінальних та відтворених препаратів
Authors: Protsiuk O.V.
Published: September 2016

На прикладі перорального цукрознижувального засобу глімепіриду в огляді літератури розглянуті відмінності оригінальних та генеричних лікарських засобів.
Недостаточность лютеиновой фазы: лабораторные аспекты диагностики. Мнение практического комитета Американского общества репродуктивной медицины (American Society for Reproduction Medicine)
Authors: Rykova O.V.
Published: September 2016

В статье освещены вопросы возможностей лабораторной диагностики недостаточности лютеиновой фазы в соответствии с документом Американского общества репродуктивной медицины «Current clinical irrelevance of luteal phase deficiency: a committee opinion», Practice Committee of the American Society for Reproductive Medicine (Fertil. Steril. 2015; 103: e27-e32. 2015 by American Society for Reproductive Medicine).
Клинико-гормональная характеристика больных с гигантскими образованиями хиазмально-селлярной области
Authors: Alimova K.B. , Urmanova Yu.M.
Published: September 2016

Цель исследования: изучить клинико-гормональную характеристику пациентов с гигантскими образованиями хиазмально-селлярной области. Материал и методы. За период с 2015 по 2016 г. обследовано 35 взрослых больных с макроаденомами гипофиза, из них 48,6 % мужчин. Средний возраст мужчин составил 37,12 года, женщин — 38,15 года. Давность заболевания колебалась в пределах от 2 месяцев до 25 лет. Результаты. Распределение больных по топографо-анатомической классификации стороны роста аденомы гипофиза показало, что наиболее часто наблюдались аденомы гипофиза с тотальным вариантом роста (51,4 %). У больных с гигантскими аденомами гипофиза наиболее часто встречались пангипопитуитаризм (44,4 %), а также битемпоральная гемианопсия (61,1 %) и вторичная аменорея (33,3 %). Такие нарушения, как вторичная остеопения, эндокринная энцефалопатия, задержка физического и полового развития, были выявлены только в этой группе больных. Кроме того, достоверное снижение средних значений базальных уровней тропных гормонов гипофиза (соматотропный гормон (СТГ), лютеинизирующий гормон (ЛГ), фолликулостимулирующий гормон (ФСГ), адренокортикотропный гормон) было зафиксировано у пациентов с гигантскими аденомами гипофиза. Выводы. У больных с гигантскими аденомами гипофиза в первую очередь отмечается снижение уровня СТГ, ФСГ, ЛГ. Наиболее выраженные нейроэндокринные и офтальмологические нарушения встречаются у больных с гигантскими аденомами гипофиза.
Синдром Нельсона: питання та відповіді (клінічний випадок)
Authors: Nizhinska-Astapenko Z.P. , Vlasenko M.V. , Hurina N.I.
Published: September 2016

Даний клінічний випадок відображає варіабельність перебігу хронічної наднирникової недостатності після проведеної двобічної адреналектомії з приводу хвороби Іценка — Кушинга, розвиток і ріст аденоми гіпофіза, що може призвести до геморагічного інсульту в самій рецидивуючій пухлині гіпофіза. Метою патогенетичних методів лікування є зниження секреції адренокортикотропного гормону, відновлення нормальної секреції тропних гормонів гіпофіза, а також запобігання подальшому росту пухлини гіпофіза й адекватна компенсація наднирникової недостатності. Випадок показує лабільний перебіг післяопераційної наднирникової недостатності та, відповідно, різні підходи до діагностики і потреби у замісній терапії на різних етапах захворювання.
Деякі питання контролю артеріального тиску. За матеріалами науково-практичної конференції «Медично-соціальні проблеми артеріальної гіпертензії в Україні» (25-27 травня 2016 р., м. Дніпро, Україна)
Authors: Kuprinenko N.
Published: September 2016

В статті наведений огляд деяких доповідей, що були представлені на науково-практичній конференції «Медично-соціальні проблеми артеріальної гіпертензії в Україні» 25-27 травня в м. Дніпро (Україна). В них зроблено акцент на призначенні багатокомпонентних схем лікування артеріальної гіпертензії.
Телмісартан проявляє органопротекцію і зменшує частоту несприятливих серцево-судинних наслідків на додаток до антигіпертензивної дії
Authors: Savustyanenko A.V.
Published: September 2016

У раніше опублікованому огляді були описані унікальні антигіпертензивні і метаболічні властивості телмісартану. Даний препарат добре знижує артеріальний тиск у нічний час і в ранкові години. Для нього характерна висока гомогенність зниження тиску протягом доби, а випадковий пропуск прийому дози не призводить до серйозних наслідків. Було відзначено високе співвідношення ефективності/безпеки, у тому числі в порівнянні з іншими антигіпертензивними засобами. Крім того, телмісартан знижував вираженість порушень вуглеводного (інсулінорезистентність) і ліпідного обміну, зменшував системну запальну відповідь і схильність до тромбозу.У цьому огляді клінічних досліджень були підтверджені органопротективні (судини, серце, нирки) ефекти телмісартану і його здатність запобігати розвитку несприятливих серцево-судинних наслідків.Телмісартан покращував судинну функцію за рахунок зменшення ендотеліальної дисфункції, жорсткості артерій і товщини інтими-медії, збільшення кількості ендотеліальних клітин-попередників, зниження частоти рестенозу після стентування і стабілізації атеросклеротичних бляшок у коронарних судинах; покращував функцію серця завдяки зменшенню гіпертрофії лівого шлуночка, збільшення функції лівого шлуночка, зниження частоти рецидивів фібриляції передсердь; покращував функцію нирок за рахунок зменшення вираженості нефропатії; знижував ризик розвитку несприятливих серцево-судинних наслідків, таких як смерть від серцево-судинних причин, частоту нефатального інфаркту міокарда та нефатального інсульту, госпіталізації з приводу серцевої недостатності, загальну смертність.Телмісартан є єдиним представником блокаторів ангіотензинових рецепторів, рекомендованим для широкого кола пацієнтів із високим серцево-судинним ризиком.
Дозозалежний вплив азилсартану медоксомілу на офісний, добовий і центральний аортальний тиск у хворих на гіпертонічну хворобу першого та другого ступеня
Authors: Dobrokhod A.S. , Sirenko Yu.M.
Published: September 2016

Азилсартану медоксоміл (АЗЛ-М) — останній представник групи блокаторів рецепторів ангіотензину II, ефективність, безпечність і добра переносимість якого вже доведені. На сьогодні доцільними є подальші дослідження АЗЛ-М щодо особливостей його впливу на офісний, добовий і центральний аортальний тиск у різних режимах дозування в певних категоріях пацієнтів. Мета — оцінити дозозалежну ефективність азилсартану за результатами вимірювання офісного, середньодобового та центрального аортального тиску в пацієнтів із м’якою та помірною артеріальною гіпертензією. Матеріали та методи. У дослідження увійшли 37 пацієнтів із гіпертонічною хворобою I та II ступеня, яким призначалася монотерапія АЗЛ-М із поступовим підвищенням дози від 20 до 80 мг один раз на добу. Тривалість лікування становила 6 місяців. На кожному візиті (з інтервалом чотири тижні) проводили добовий моніторинг аортального тиску (ABPM, Meditech, Угорщина) та вимірювання офісного та центрального аортального тиску (SphygmoCor CVMS, Atcor, Австралія). Результати та обговорення. Офісний систолічний і діастолічний аортальний тиск знизився на 21,8 та 10,2 мм рт.ст. відповідно, p < 0,0001. До того ж підвищення дози призводило до посилення антигіпертензивного ефекту. Спостерігалося достовірне дозозалежне зниження середньодобових систолічного та діастолічного аортального тиску, різниця становила 14,3 ± 0,8 і 9,8 ± 0,4 мм рт.ст. відповідно, p < 0,0001. Також підтвердилася дозозалежна ефективність АЗЛ-М щодо зниження центрального аортального тиску, що зменшився порівняно з початковими цифрами на 18,00 ± 2,92 мм рт.ст., р < 0,005. Висновки. Отримані результати свідчать про дозозалежний характер впливу АЗЛ-М на офісний, середньодобовий аортальний тиск за результатами добового моніторингу аортального тиску та центральний аортальний тиск у хворих на гіпертонічну хворобу І і ІІ ступеня.
Ефективність і безпечність фіксованих комбінацій блокаторів повільних кальцієвих каналів, блокаторів рецепторів ангіотензину та тіазидних діуретиків у лікуванні артеріальної гіпертензії
Authors: Kupnovytska I.G. , Kutynska I.P. , Klymenko V.I. , Danyliuk O.I.
Published: September 2016

Наведено аналіз результатів дослідження ефективності й безпечності фіксованих комбінацій блокатора повільних кальцієвих каналів (БКК) амлодипіну й блокатора рецепторів ангіотензину (БРА) валсартану (Комбісарт) та амлодипіну, валсартану й тіазидного діуретика гідрохлортіазиду (Комбісарт Н) компанії ПАТ «Київський вітамінний завод» порівняно з препаратами Ексфорж й Ексфорж Н (Novartis Pharma, Швейцарія) у лікуванні хворих на артеріальну гіпертензію ІІ–ІІІ стадії. Установлена терапевтична еквівалентність Комбісарту і Комбісарту Н референтним — Ексфоржу й Ексфоржу Н. Продемонстрована ефективність досліджуваних препаратів щодо зниження артеріального тиску, покращення його контролю протягом доби при комбінації БРА і БКК із тіазидним діуретиком, добра переносимість Комбісарту і Комбісарту Н, що підвищує комплайєнтність пацієнтів до лікування артеріальної гіпертензії.
Exact solutions of time fractional heat-like and wave-like equations with variable coefficients
Authors: Zhang Sheng , Zhu Ran , Zhang Luyao
Published: September 2016

In this paper, a variable-coefficient time fractional heat-like and wave-like
equation with initial and boundary conditions is solved by the use of
variable separation method and the properties of Mittag-Leffler function. As
a result, exact solutions are obtained, from which some known special
solutions are recovered. It is shown that the variable separation method can
also be used to solve some others time fractional heat-like and wave-like
equation in science and engineering.
Solving non-local fractical heat equations based on the reproducing kernel method
Authors: Li Xiuying , Wu Boying
Published: September 2016

In this paper, a numerical method is proposed for 1-D fractional heat
equations subject to non-local boundary conditions. The reproducing kernel
satisfying nonlocal conditions is constructed and reproducing kernel theory
is applied to solve the considered problem. A numerical example is given to
show the effectiveness of the method.
Exact solutions for the differential equations in fractal heat transfer
Authors: Yang Chun-Yu , Zhang Yu-Dong , Yang Xiao-Jun
Published: September 2016

In this article we consider the boundary value problems for differential
equations in fractal heat transfer. The exact solutions of non-differentiable
type are obtained by using the local fractional differential transform
method.
Characteristic equation method for fractal heat-transfer problem via local fractional calculus
Authors: Liu Geng-Yuan
Published: September 2016

In this paper the fractal heat-transfer problem described by the theory of
local fractional calculus is considered. The non-differentiable-type solution
of the heat-transfer equation is obtained. The characteristic equation method
is proposed as a powerful technology to illustrate the analytical solution of
the partial differential equation in fractal heat transfer.
A new computational method for fractal heat-diffusion via local fractional derivative
Authors: Liu Geng-Yuan
Published: September 2016

The fractal heat-conduction problem via local fractional derivative is
investigated in this paper. The solution of the fractal heat-diffusion
equation is obtained. The characteristic equation method is proposed to find
the analytical solution of the partial differential equation in fractal
heat-conduction problem.
Local fractional variational iteration algorithm iii for the diffusion model associated with non-differentiable heat transfer
Authors: Meng Zhi-Jun , Zhou Yao-Ming , Wang Huan-Qing
Published: September 2016

This paper addresses a new application of the local fractional variational
iteration algorithm III to solve the local fractional diffusion equation
defined on Cantor sets associated with non-differentiable heat transfer.
About local fractional three-dimensional compressible Navier-Stokes equations in Cantor-type cylindrical co-ordinate system
Authors: Gao Guo-Ping , Cattani Carlo , Yang Xiao-Jun
Published: September 2016

In this article, we investigate the local fractional 3-D compressible
Navier-Stokes equation via local fractional derivative. We use the
Cantor-type cylindrical co-ordinate method to transfer 3-D compressible
Navier-Stokes equation from the Cantorian co-ordinate system to the
Cantor-type cylindrical co-ordinate system.
The method of separation of variables for local fractional Korteweg-de Vries equation
Authors: Zhuang Jia-Yu , Qiao Peng , Li Zhe-Min
Published: September 2016

This paper presents the analytical solution of the local fractional linear
Korteweg-de Vries equation in (1 + 1) fractal dimensional space by using the
method of separation of variables.
Wellbore stability analysis in chemically active shale formations
Authors: Shi Xiang-Chao , Yang Xu , Meng Ying-Feng , Li Gao
Published: September 2016

Maintaining wellbore stability involves significant challenges when drilling
in low-permeability reactive shale formations. In the present study, a
non-linear thermo-chemo-poroelastic model is provided to investigate the
effect of chemical, thermal, and hydraulic gradients on pore pressure and
stress distributions near the wellbores. The analysis indicates that when the
solute concentration of the drilling mud is higher than that of the formation
fluid, the pore pressure and the effective radial and tangential stresses
decrease, and v. v. Cooling of the lower salinity formation decreases the
pore pressure, radial and tangential stresses. Hole enlargement is the
combined effect of shear and tensile failure when drilling in
high-temperature shale formations. The shear and tensile damage indexes
reveal that hole enlargement occurs in the vicinity of the wellbore at an
early stage of drilling. This study also demonstrates that shale wellbore
stability exhibits a time-delay effect due to changes in the pore pressure
and stress. The delay time computed with consideration of the strength
degradation is far less than that without strength degradation.
Pneumococcal meningitis associated with glomerulonephritis: A case report
Authors: Vuletic Biljana , Stojkovic Andjelka , Igrutinovic Zoran , Stankovic Lidija , Medovic Rasa , Dajic Katerina , Stojkovic Tanja , Jankovic Marijana , Jankovic Sveta , Vujic Ana
Published: September 2016

Introduction. Streptococcus pneumoniae is the second most common cause of meningitis in children, producing more serious complications than other bacteria. Streptococcus pneumoniae infections are a rare trigger of glomerulonephritis. We presented a case of glomerulonephritis developing concurrently with meningitis in a young male child. Case report. Gross haematuria, significant proteinuria, hypertension and decreased level of C3 alongside the signs of central nervous system involvement occurred in a male patient of 5 years and 3 months of age. Spontaneous resolution of renal affliction parameters followed the successful treatment of meningitis. The disease course was strongly suggestive of postinfectious glomerulonephritis, although it manifested at the same time as meningitis. The absence of the latent period might point to the development of IgA nephropathy, but since the renal function was stable, without any abnormalities in urine tests documented during follow-up, our opinion is that this was rather the case of postinfectious nephropathy. Conclusion. The presented case is a unique clinical form of postinfectious glomerulonephritis. An accurate diagnosis of this entity should ensure the adequate treatment and follow-up of these patients.
Complications of radical and partial nephrectomy for renal cell carcinoma up to 7 cm
Authors: Maric Predrag , Jovanovic Mirko , Milovic Novak , Stamenkovic Dusica , Kosevic Branko , Aleksic Predrag , Cerovic Snezana , Spasic Aleksandar , Simic Dejan , Raskovic Jelena
Published: September 2016

Background/Aim. Renal cell carcinoma (RCC) is the third most frequent urological carcinoma. Radical nephrectomy (RN) is considered as the gold standard in the treatment of localized RCC, but recently the use of minimally invasive techniques are more frequently used. The aim of this study is to determine is there a difference in the incidence of complications in the group of patients treated by RN and partial nephrectomy (PN) for renal cell carcinoma up to 7 cm. Methods. The retrospective study included the analysis of the medical history of patients surgically treated in the six years period. The inclusion criteria were RCC size up to 7 cm and no detectable metastasis. The exclusion criterion was the presence of a bilateral tumor. Intraoperative and early postoperative complications were followed-up. The Clavien- Dindo grade system was used for classification of surgical complications. Results. In six years period 481 (76.35%) radical transperitoneal nephrectomies and 149 (23.65%) partial nephrectomies were performed. Bilateral RCCs were verified in 2.06% (13/630), an initial metastatic disease in 15.8% (100/630) and lymph node involvement in 7.14% (45/630) of the patients and their data were not included in analysis. Therefore, data from 120 patients with RN and 97 patients with PN who fulfill inclusion criteria were analyzed. Complications were recorded in 29.5% (64/217) of patients. Significantly less patients had complications in the RN group [22.5 % (27/120)] compared to the PN group [38.1% (37/97)] (p = 0.006). These complications were mostly grade I and II. Complications grade III and IV were only present in the group of patients treated by PN. Conclusion. Based on our data in selected patients with renal cell carcinoma in stage T1, PN is a proper and safe choice. The patient must be involved in making the definitive decision of modalities of surgical treatment.
Gifts from orthodontists to general dentists
Authors: Al-Mahdi Ammar , Firestone Allen R , Beck Frank , Fischbach Henry
Published: September 2016

Objectives: To determine how often general dentists receive gifts from orthodontists, the value and number of the gifts they receive, and how they perceive the motivation behind the gift.

Materials and Methods: This was a questionnaire-based study. A questionnaire was constructed and tested for validity and reliability. An electronic version of survey was sent via email to 1300 general dentists.

Results: The validity and reliability of the survey was confirmed. Two hundred fifty-four valid responses were received (20%). Eighty-five percent of responding general practitioners reported that they received gifts from an orthodontist. Almost 100% reported that they referred patients to orthodontists. About one-third of the responding general practitioners reported that their office provided orthodontic care. There were statistically significant correlations between the number of annual patient referrals the general practitioners reported making and the number and value of the gifts they received from the orthodontists. Female general practitioners reported receiving a higher number of gifts of greater total value than male practitioners. General practitioners who reported providing orthodontic treatment did not differ from those who did not in the number of referrals they made annually and the number and value of the gifts they received. Quality of care was the most common reason general practitioners reported for their referral to an orthodontist. Forty-four percent of the responders reported that they received discounted orthodontic treatment.

Conclusions: General practitioners refer patients to orthodontists and receive gifts from them. The number and value of the gifts reflects the number of referrals they make.
Laser synthesis of 2D heterostructures of transitional metal oxides for photo sensors with high sensitivity
Authors: Mulenko S. A. , Stefan N. , Miroiu F. , Mihailescu I. N. , Gorbachuk N. T. , Nikirin V. A.
Published: September 2016

Photons of a KrF laser (248 nm) were used for the synthesis of Cr3−XO3−Y/Fe2O3−X two dimensional (2D) multilayer heterostructures by reactive pulsed laser deposition. Each nanometric multilayer heterostructure with a definite number of layers of iron and chromium oxides was deposited in 2D form on ⟨100⟩ Si substrate at its temperature 293 or 800 K resulted in changing of 2D multilayer heterostructure thickness in the range of 25–85 nm. X-ray diffractometer analysis confirmed polycrystalline structure of these deposits. Element analysis was carried out by an energy dispersive x-ray spectroscopy. All synthesized 2D multilayer heterostructures demonstrated semiconductor temperature trend with variable equivalent energy band gap (Eg) in the range of 0.36–0.87 eV. The more substrate temperature was the more Eg value, and the more 2D multilayer heterostructure photosensitivity. Optimum experimental parameters were found out to obtain the highest photosensitivity of 2D multilayer heterostructure. Highest obtained photosensitivity was high as 420 VC/W at white light power density ∼6 × 10−3 W/cm2. VC is “chemical” photo electromotive force induced in the deposited 2D multilayer heterostructure while it irradiating with a white light, W is white light power. High photosensitivity nature of the 2D multilayer heterostructure synthesized on a heated substrate was explained. Therefore, such 2D multilayer heterostructures of iron and chromium oxides exhibiting high photosensitivity are exceptionally a strong candidate for effective photo sensors of white light.