bluuebunny/crossref_metadata_2025 huggingface dataset:
Agricultura y Deforestación en la Amazonía Peruana: Una Revisión Bibliométrica
Authors: La Rosa Salazar Miguel Angel
Published: September 2024

The study presents a comprehensive bibliometric review of the literature that explores the vital connection between agriculture and deforestation in the Peruvian Amazon. The review included a systematic search of the Scopus, SciELO, and Dialnet databases, as well as Google Scholar, resulting in 1064 records, with 64 selected for the review. The documents were obtained from various sources and involved 161 contributing authors, mainly affiliated with institutions in Peru and focused on agricultural sciences. The collected documents spanned a wide time frame from 1940 to the present, covering 11 departments and utilizing both qualitative and quantitative research methods, with a notable emphasis on Geographic Information Systems (GIS). However, the review identified a significant concentration in certain variables, such as 93.8% of the documents being from Scopus and Google Scholar. It is worth noting that Google Scholar substantially increased the size of the document corpus. The review also highlighted a predominant focus on Ucayali (23) and Loreto (15) and the twenty-first century. Recommendations include (i) giving priority to the use of Google Scholar in future reviews, (ii) conducting further studies in less-studied Amazon departments, particularly those experiencing significant deforestation such as Huánuco and San Martín, and (iii) delving into the historical perspective to facilitate discussions regarding the relevance for the Peruvian Amazon of impactful events concerning the national agricultural sector.
Avances en los estudios económicos sobre recursos naturales en el Perú durante el periodo 2016-2021
Authors: Orihuela Carlos
Published: September 2024

This review contains several economic investigations on natural resources from 2016-2021. Most of these researchers relate this research biodiversity and ecosystem services. In the latter case, most of it comes from a thesis. A lot of studies come from public universities, which is an encouraging detail; however, less than half of such studies have managed to be published in a scientific journal. These results show the growing interest of academics in several topics, such as the environmental management of natural resources.
Sleep Disturbances and Depression Levels among General Indonesian Population: A National Survey
Authors: Alfian Sofa D. , Thurfah Jihan N. , Griselda Meliana , Puspitasari Irma M.
Published: September 2024

Background

The correlation between sleep disturbance and depression is widely recognized in developed countries but relevant evidence is lacking in developing countries.

Objective

This study aims to assess the correlation between sleep disturbance and depression levels among the general Indonesian population.

Methods

This national cross-sectional survey was conducted using the Indonesian Family Life Survey. Sleep disturbance was assessed based on the questions related to sleeping experience. Depression levels were assessed with a modified Center for Epidemiologic Studies-Depression scale. Sociodemographic factors as confounders were obtained from the self-reported data. Logistic regression was performed after adjusting for confounders.

Results

A total of 22,024 respondents were included. Respondents with severe, moderate, and mild sleep disturbance were associated with depression compared to those with none or slight sleep disturbance.

Conclusions

Respondents with sleep disturbance had a higher possibility of experiencing depression. Screening of sleep quality among the general population is important to reduce the risk of depression.
TRIM65 Promotes Osteogenic Differentiation by Regulating the PI3K/AKT Signaling Pathway
Authors: Li Hong-Pu , Zeng Ting-Ting , Zhou Zhi-Xiang , Xiao Xiang , Liang An-Yu , Liu Yi-Fan , Wang Ming , Luo Yong-Jian , Xiao Jian , Xiao Jun
Published: September 2024

Introduction

Tripartite motif 65 (TRIM65) is a crucial regulator of cell differentiation, proliferation, migration, invasion, and carcinogenesis. However, its role in osteoporosis (OP) remains unclear. In this study, we evaluated the role of TRIM65 in regulating osteoblast differentiation and calcification.

Materials and Methods

The role of TRIM65 during the osteogenic differentiation of MC3T3-E1 cells was evaluated. The expression of COL1A1, RUNX2, and OCN was examined using western blot analysis and immunofluorescence staining. The formation of calcium nodules was evaluated using alizarin red staining. Alkaline phosphatase activity was evaluated using ALP staining.

Results

TRIM65 expression was significantly elevated during the osteogenic differentiation of bone marrow mesenchymal stem and MC3T3-E1 cells. We demonstrated that TRIM65 overexpression enhanced osteogenic differentiation and promoted bone formation in the MC3T3-E1 cells. Conversely, TRIM65 inhibited the osteogenic differentiation and bone formation of the MC3T3-E1 cells. Mechanistically, we found that TRIM65 knockdown in MC3T3-E1 cells up-regulated the phosphorylated protein expression of PI3K and AKT, which was contrary to the results of the TRIM65-overexpression group.

Conclusion

Our research suggests that TRIM65 is an important osteogenic differentiation and bone formation regulator and offers a therapeutic application for OP.
Parameter Optimization of Single-Stage Isolated Bidirectional DC/AC Converters based on Ant Lion Optimizer
Authors: Li Xinhao , Miao Yu , Fu Yu , Li Dewei , Yang Nuo , Zhao Xiaojun , Wang Haoming
Published: September 2024

Background:

The extensive utilization of the dual active bridge (DAB) topology in the
domain of power electronics has led to the prevalence of DC/AC converters based on DAB that
adopt two-stage conversion and phase-shifting control strategies in their design. This has resulted
in an increase in losses and complexity in practice.

Objective:

The objective of this study is to propose a parameter optimization method for a singlestage
isolated bidirectional DC/AC converter, utilizing a hybrid control method of variable frequency
and phase shift control to enhance the efficiency of the converter.

Method:

The use of a single-stage topology eliminates the DC link composed of decoupling capacitors
in the middle. Subsequently, the equal power method was employed to facilitate frequency
conversion and phase shift control. Furthermore, the LC parameters of the converter were optimized
based on the multi-objective ant lion optimizer.

Results:

A simulation model was constructed based on a single-stage grid-connected system. In
comparison to the multi-objective particle swarm optimization algorithm and the multi-objective
sparrow algorithm, the LC parameters optimized by the multi-objective ant lion algorithm demonstrated
a reduction in the THD of grid-connected current by 27% and 66%, respectively. The optimized
parameters result in a reduction in the harmonic distortion rate of the grid-connected current
to 1.3% and an improvement in efficiency to 90%.

Conclusion:

The simulation results have demonstrated the efficacy and precision of the parameter
optimization strategy, and the proposed optimization strategy has the potential to enhance the performance
of grid-connected systems.
Geometric study of two dimension honeycomb reentrant auxetic structures to transformable architecture
Authors: Álvarez Elipe Mª Dolores
Published: September 2024

Introduction:

Transformable architecture heavily depends on grasping geometry. Some
natural materials possess geometric traits leading to similar structural responses when their size
changes, resulting in diverse spatial shapes. Auxetic materials demonstrate a negative Poisson's
ratio, enabling them to shift from lines to surfaces, and from surfaces to volumes or spatial
frameworks. The background of this research focuses on evaluating and establishing honeycomb
reentrant auxetic geometries to craft innovative architectural spaces capable of transformation. By
methodically examining the geometric attributes of these structures at both molecular and macroscopic
levels, they could play a crucial role in architectural development.

Method:

The method of this investigation entails a comparative Computer-Aided Design (CAD)
study of 2D honeycomb reentrant auxetic patterns. The objective is to employ CAD to gain deeper
insights into these patterns for architectural applications.

Result:

As a result, the study evaluates the geometric performance of various 2D honeycomb
reentrant auxetic patterns, systematically comparing them based on criteria such as the maximum
achievable area reductions relative to the total length of the structure's bars.

Conclusion:

The conclusion is to ascertain a growth factor for these structures.
New data in stroke patient’s rehabilitation
Authors: Tsigaras Georgios , Chalkia Anna , Kallistratos Ilias , Vargiami Efthimia , Katsantoni Dimitra , Giannakopoulos Fanis
Published: September 2024

Stroke has a special place in clinical neurology as the brain is the center of the nervous system. They require immediate treatment as the time burden can dramatically worsen their development. The distinction of stroke it is done in the form of damage. 80-88% are ischemic strokes and 12-20% are hemorrhagic strokes. The clinical manifestations of cerebrovascular attacks depend on the location of the damage in the brain parenchyma and specifically in the affected vessel. The separation of cerebral ischemia and hemorrhage syndromes follows anatomical criteria because it depends on the arterial branch that is damaged. The factors that favor stroke with the main causes being hypertension, atherosclerotic plaque rupture, heart diseases as well as people's lifestyle, are a large part of nursing for their prevention in the general population. The global knowledge of the brain (anatomy and physiology) and the understanding of the functioning of strokes helps us as nurses to enrich our knowledge and have a general picture of the patient, without focusing only on the treatment. The treatment requires very good medical and nursing staff and their cooperation with physiotherapists, speech therapists, and other health scientists, who will plan the treatment.
Toxic masculinity dan tantangan kaum lelaki dalam masyarakat Indonesia modern
Authors: Hermawan Irfan , Hidayah Nur
Published: September 2024

Fenomena toxic masculinity menggambarkan sikap dan perilaku laki-laki yang merugikan diri sendiri, orang lain, dan masyarakat secara umum. Dengan menggunakan pendekatan fenomenologi berdasarkan data kualitatif hasil wawancara dengan beberapa laki-laki di Yogyakarta, kami mendalami toxic masculinity terutama dampaknya pada kehidupan sehari-hari. Hasil penelitian menemukan adanya berbagai macam motif atau bentuk-bentuk dari perilaku toxic masculinity seperti tabu menggunakan skincare, tidak boleh menangis, harus selalu kuat, tidak mengalami pelecehan seksual, dan lain sebagainya yang tentu saja merugikan kaum laki-laki. Selain itu hasil penelitian ini mengidentifikasi tekanan psikologis, intimidasi dan pengucilan, serta bullying sebagai bagian dari fenomena ini yang mempengaruhi kehidupan kaum laki-laki dalam masyarakat modern Indonesia.
Resiko dan dampak sosial judi dan pinjaman online pada remaja
Authors: Rohmah Yusriyyatur , Khodijah K
Published: September 2024

Penelitian mengeksplorasi tren judi online dan pinjaman online pada kelompok remaja dengan mendalam pendorong dan resiko serta dampak sosial yang ditimbulkannya. Judli online termasuk yang dilarang di Indonesia mempertimbangkan berbagai dampak dan resiko sosialnya. Dengan melakukan kajian literatur yang relevan, beberapa aspek terkait pendorong, resiko dan dampak sosial judi online dan pinjaman online dieksplorasi dan didalami dengan seksama. Hasilnya, penelitian menyetakan bahwa faktor penyebab dari judi online dan juga  pinjaman online yang mayoritas berasal dari iklan-iklan yang ada di sebuah situs Internet ataupun media sosial. Dengan masih rendahnya pemahaman remaja tentang judi online ini, mereka menjadi kelompok yang sangat rentan mengalami dampak sosial pabila terjerat di dalamnya.The research explores the trend of online gambling and online loans among teenagers in depth on the drivers, risks and social impacts it causes. Online gambling is prohibited in Indonesia considering the various social impacts and risks. By conducting a review of relevant literature, several aspects related to the drivers, risks and social impacts of online gambling are explored and studied carefully. As a result, research states that the majority of factors causing online gambling and online loans come from advertisements on internet sites or social media. With teenagers' low level of understanding about online gambling, they are a group that is very vulnerable to experiencing social impacts if they are entangled in it.
Semua adalah masyarakat: intervensi paradigma monadologi Gabriel Tarde untuk radikalisasi Sosiologi
Authors: Rafiq Devananta
Published: September 2024

Artikel ini merupakan upaya memperkenalkan kembali gagasan sosiolog Gabriel Tarde melalui kajian kualitatif yang dilakukan dengan metode penggalian data studi pustaka. Dari hasil penelusuran ditemukan bahwa Tarde melalui teorisasi ‘monadologi’ berhasil memperluas cakupan definisi masyarakat pada segala hal yang ada (‘everything is society’). Dari situ, artikel ini berusaha berargumen bahwa pemikiran Tarde ini menandai peralihan secara radikal diskursus sosiologi dari yang sekadar dimaknai sebagai ‘ilmu mengenai masyarakat’ (science about the society) menjadi ‘ilmunya masyarakat’ (the science of society). Jenis pemerian monadologi ini kemudian bisa secara praktis dipergunakan pada paradigma ‘actor-network theory’ (ANT) yang banyak dikembangkan oleh Bruno Latour untuk mendorong semakin terlibatnya sosiolog dengan kenyataan sosial yang ditelitinya.This article aims to reintroduce the ideas of sociologist Gabriel Tarde with a research that is conducted through a qualitative study using literature studies. From the research, it was found that through his theorization of ‘monadology’, Tarde managed to expand the scope of society’s definition to include everything that exists (thus: ‘everything is society’). From there, this article argues that Tarde’s thinking marks a radical shift in sociological discourse: from being simply interpreted as ‘the science about the society’ to ‘the science of society’. This type of monadological explication can then be used in the ‘actor-network theory’ (ANT) paradigm that has been developed by Bruno Latour to encourage sociologists to become more involved with the social reality they study.
Sosiabilitas Lapo tuak dalam pendampingan mayasrakat Batak Toba
Authors: Simatupang Andreas Fredriko , Tampake Tony
Published: September 2024

Lapo tuak merupakan bagian penting dalam fasilitasi dan sosialisasi dalam masyarakat Batak Toba di Sumatera Utara. Anggota masyarakat bertemu, berkumpul, bercengkarama dan seringkali membahas berbagai masalah dan pencarian solusinya dalam kehidupan sehari-hari di lingkungannya. Penelitian kualitatif ini berupaya mendalami potensi dan fasilitasi Lapo tuak sebagai wahana pemberdayaan dan pembimbingan kehidupan sosial kemasyarakatan. Hasil penelitian menunjukkan bahwa interaksi sosial di lapo tuak melibatkan berbagai aspek seperti tempat pertemuan sosial, pengembangan potensi diri, keterbukaan, keramahan, pola komunikasi, pertunjukan budaya, norma sosial, serta pemeliharaan hubungan keluarga. Pendampingan masyarakat di lapo tuak membantu pengembangan potensi diri, pencarian makna hidup, kerja sama, kolaborasi, dan pengembangan keterampilan kepemimpinan, yang mencerminkan nilai-nilai budaya dan solidaritas komunitas masyarakat Batak Toba.Lapo tuak plays a significant role in facilitating social interactions within the Batak Toba community in North Sumatra. Members come together at Lapo tuak to socialize, engage in discussions, and seek solutions to everyday challenges. This qualitative research aims to investigate the potential of Lapo tuak as a tool for empowerment and social guidance within the community. The study's findings reveal that social interactions at Lapo tuak encompass various aspects, including acting as meeting places, fostering self-development, promoting openness and friendliness, shaping communication patterns, showcasing cultural performances, upholding social norms, and strengthening family ties. Community involvement at Lapo tuak contributes to the development of individuals' potential, the quest for life's purpose, cooperation, collaboration, and the enhancement of leadership skills. These outcomes reflect the cultural values and solidarity within the Batak Toba community.
Jaringan dan kepercayaan: modal sosial pemasaran industri rumah tangga kerupuk sagu di Pamekasan
Authors: Arifin Zainol , Rosyadi Khoirul
Published: September 2024

Upaya meningkatkan pendapatan industri skala kecil-menengah tingkat rumah tangga tidak lepas dari keberhasilan membangun dan memelihara modal social terkait. Sebagaimana ditunjukkan dalam industri rumah tangga kerupuk sagu, peran jaringan dan kepercayaan pihak-pihak terkait sangat penting. Dengan menggunakan metode kualitatif melibatkan para pelaku usaha kerupuk sagu di Bulay, Pamekasan, Madura, penelitian menelaahnya dengan menggunakan teori modal sosial. Hasil penelitian ini menunjukan bahwa modal sosial memiliki peranan penting dalam meningkatkan pemasaran industri rumah tangga kerupuk sagu dalam segi pendapatan dan perluasan pemasaran kerupuk sagu. Jaringan sosial dalam pemasaran melalui jaringan sesama produsen industri rumah tangga kerupuk sagu, jaringan pertemanan dan keluarga, jaringan dengan pedagang, jaringan dengan pengelola wisata di sekitar wilayahnya dan jaringan dengan pemasok bahan baku. Kepercayaan dalam pemasaran industri rumah tangga kerupuk sagu melalui konsumen, pedagang, dan pengelola wisata di wilayah Pamekasan.The success of small and medium-sized household industries in increasing their income relies heavily on the development and maintenance of social capital. The sago cracker household industry serves as an example where the role of networks and trust among relevant parties is crucial. This study, based on qualitative methods involving sago cracker business actors in Bulay, Pamekasan, Madura, utilized social capital theory to examine the phenomenon. The findings of the study highlight the significant role of social capital in enhancing the marketing and expanding the income of sago cracker household industries. This includes social networks established with fellow sago cracker producers, friends and family, traders, local tourism managers, and raw material suppliers. Trust also plays a critical role in marketing sago cracker household industries, particularly in relationships with consumers, traders, and tourism managers in the Pamekasan area.
Theoretical Underpinning of Groundwater situation in India: Search for Efficient Policy Mechanism
Authors: Banerjee Alik , Parikh Alka , Gupta Aahwani Kumar
Published: September 2024

At the outset of the 21st century, water scarcity and water insecurity became inextricable in almost every world region. India, being a subcontinent, is not an exception because of its diverse geographical conditions. The paucity of water is severely impairing India's sectoral prosperity. Like many other natural resources, we have taken the availability of water for granted; we continue to expect bounty as soon as we turn on the tap. However, the recent dearth has raised a few questions, not on the right, instead of on the legal responsibility. The quest for an answer, thus, brings us to the polemics of economics, where anything scarce and demanding high needs a price. Effective water pricing policy brings an appropriate incentive to ensure enough clean water for all stakeholders who demand it and secures financial sustainability for urban water services providers to supply it. Water scarcity and its price mechanism can be addressed by refining ways, means, and models and considering the water sector's institutional structure. Since it is crucial to comprehend the issue of water shortage, the policy's goal should be to raise public awareness of the state of affairs and provide a framework of institutions and regulations that will allow the state to implement its policies in a coordinated way.
Crecimiento de clones de Hevea brasiliensis (Willd. ex A.Juss.) Müll.Arg. en etapa juvenil establecidos en campos clonales, Meta, Colombia.
Authors: Castañeda-Garzón Sandra Liliana , Rivano Franck , Mora Garcés Argenis Antonio
Published: September 2024

Hevea brasiliensis es la mayor fuente de caucho natural y materia prima en la manufactura de diversos productos industriales, en Colombia se ha establecido comercialmente en cinco núcleos productivos. Sin embargo, la base genética es reducida y enfermedades foliares han comprometido el desarrollo y la producción. En el Centro de Investigación La Libertad (Villavicencio) y la Finca Experimental Taluma (Puerto López) de la Corporación Colombiana de Investigación Agropecuaria – AGROSAVIA, se establecieron campos clonales a pequeña y gran escala para la evaluación del desempeño asociado al crecimiento de siete clones de la colección CIRAD-Michelin Selection de las series CDC, FDR, MDF y PMB, junto a FX 3864 y RRIM 600. En etapa juvenil se midió semestralmente la circunferencia del tronco (CIRC) y se calculó el incremento medio anual de esta variable (IMA-CIRC), se realizó análisis de varianza y comparación de medias. A edad de ocho años el clon FDR 5788 presentó un IMA-CIRC de 8,20 cm año-1 y 6,87 cm año-1 en La Libertad y Taluma respectivamente; se observó crecimiento diferencial entre clones. En Piedemonte llanero (La Libertad) se destacaron por su crecimiento los clones FDR 5788 y RRIM 600, mientras que en Altillanura (Taluma) fueron PMB 1 y FDR 5788. En La Libertad los clones FDR 5788, RRIM 600 y CDC 312 superaron 50 cm de CIRC al sexto año, a diferencia de Taluma, donde esto sucedió al séptimo año para PMB 1 y FDR 5788.
Respuestas fisiológicas y productivas de plantas de remolacha tratadas con una solución de aminoácidos
Authors: Peña Calzada Kolima , Calero Hurtado Alexander , Peistrup Victoria , Mühlmann Isabel , Rodríguez Miranda Danieya , Rodríguez Coca Liuder I. , Rodríguez González Manuel , Rodríguez Fernández Juan C.
Published: September 2024

El crecimiento exponencial de la población mundial hace necesario buscar alternativas para incrementar la producción de alimentos. Los aminoácidos se utilizan ampliamente para mejorar la productividad de los cultivos, sin embargo, en el cultivo de la remolacha roja no está generalizado su uso. Por lo que el objetivo de la investigación fue evaluar el efecto de la aplicación foliar de una solución de aminoácidos en los índices fisiológicos y la producción de la remolacha roja. Se diseñó un experimento en bloques al azar con cinco tratamientos y seis réplicas. Fueron evaluadas cuatro concentraciones de la solución de aminoácidos VA1 (0,3 ml L-1), VA2(0,6 ml L-1), VA3(0,9 ml L-1), VA4(1,2 ml L-1) y un tratamiento control VA0 (0). Se evaluó la biomasa seca de las plantas, área foliar, tasas de crecimiento, contenido de clorofilas totales, temperatura de las hojas, contenido relativo de agua y el rendimiento agrícola. Los resultados mostraron menor crecimiento y producción cuando no se usó la solución de aminoácidos y un incremento significativo de la biomasa seca de las plantas cuando se usó la solución en todas sus variantes. Las tasas de crecimiento, el contenido de clorofilas, así como la temperatura de las hojas, también fueron beneficiadas por los aminoácidos. La mayor eficiencia productiva se obtuvo con 0,6; 0,9 y 1,2 ml L-1 y la mejor respuesta en el rendimiento fue de la dosis 1,2 ml L-1. Por lo que la aplicación foliar de aminoácidos es una alternativa para incrementar el crecimiento y la producción de remolacha roja.
Implementation of the primary health care system in various countries: a systematic review
Authors: Setya Budi Rocky , Adisasmito Wiku Bakti Bawono
Published: September 2024

Purpose: Primary health care (PHC) focuses on the community as individuals, families, and communities, which prioritizes health promotion and disease prevention over treatment, rehabilitation, and palliative care. PHC implementation often sacrificed the prevention approach because it was hampered by health medicalization.
Methods: This Systematic Review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The author searched five databases: EMBASE, ProQuest, ScienceDirect, Scopus, and PubMed, to discover the primary health care system implementation in various countries.
Result: Searches on the EMBASE database included 193 articles, ProQuest 347 articles, PubMed 589 articles, ScienceDirect 294 articles, and Scopus 293 articles. Reports were assessed for eligibility, the remaining 39 full-text articles were reviewed, and the authors chose ten relevant and suitable articles for further review.
Conclusions: The medicalization of health, a shortage of skilled health workers, poor services, a weak referral system, treatment that does not meet the needs of the community, a lack of public-private partnerships in the provision of health services, and a lack of stakeholder involvement in policy-making continues to impede PHC implementation. In the future, stakeholders should cover the gap between public health and primary care through integration.
Risk factors for neonatal death in Sleman Regency: analysis of Sleman HDSS data for 2015-2020
Authors: Yanti Windra , Wahab Abdul , Wahdi Amirah Ellyza
Published: September 2024

Purpose: This study aims to address the critical issue of neonatal mortality, which remains a significant public health concern, particularly in low and middle-income countries where 75% of neonatal deaths occur within the first week of life, and approximately one million newborns die within the first 24 hours, influenced by various maternal and neonatal risk factors.
Methods: This was an observational study that used a longitudinal design. The sample size was 824 respondents born and living in Sleman, DIY. The purpose of this study was to identify risk factors for neonatal death. Data analysis used descriptive analysis, bivariable, and multivariable.
Results: Multivariable analysis showed that the risk factors associated with the incidence of neonatal death were the mother's age (OR=143.4; CI: 16.92-1215.36), baby's weight (OR=15.24; CI: 1.8-112.92), and history of abortion (OR=9.27 CI; 1.7-50.33).
Conclusion: Based on the results of the study, maternal age is the most influential risk factor for the incidence of neonatal death in Sleman Regency. Mothers who are pregnant and give birth aged <18 years have a risk of 143.4 times higher for neonatal death compared to women who are pregnant and give birth aged 18-34 years. Therefore it is necessary to increase education and empower women to prevent early marriage.
Barriers and facilitators to improving routine vaccination coverage in East Aceh during the COVID-19 pandemic: a qualitative study
Authors: Okfriani Coraima , Martha Evi
Published: September 2024

Purpose: East Aceh is one of the districts in Aceh Province that has a low rate of routine vaccination of children, especially in a pandemic situation. It is essential to research to understand more about the challenges in providing vaccination services due to COVID-19.
Methods: This study used a qualitative approach with Rapid Assessment Procedure. Data was collected in three Puskesmas in East Aceh with the lowest vaccination coverage areas. The targeted participants in this study were: Caregivers, Health workers, Community cadres, Vaccine coordinators, and Vaccine advisors.
Result: The phenomenon of COVID-19 vaccine refusal influenced caregivers’ to also refuse routine vaccination. Husband or father had a big role in determining whether children could get vaccinated. Caregivers were also afraid of vaccine side effects and vaccination methods using syringes as they often heard negative rumors about it. The lack of influential figure support also affected communities' perception of vaccination. On the other hand, several things might influence caregivers to bring their children to get vaccinated. Regular reminders from village midwives might influence caregivers to visit posyandu to get their children vaccinated. Good knowledge of the benefits of immunization for children is also important to raise caregivers’ awareness.
Conclusion: This study recommends stakeholders and health professionals improve routine immunization programs, particularly in pandemic situations. The findings are anticipated to guide the creation of health campaign strategies encouraging caregivers to bring their children in for vaccinations.
Comparing cost-effectiveness of implant and IUD contraception in women: a systematic review
Authors: Amalia Silviatul , Nafisah Khilda Durrotun , Muliyani Navantri , Jusrawati  , Dary Sry Wulan , Sulistyaningsih  , Hafidz Firdaus
Published: September 2024

Purpose: The use of long-acting reversible contraception (LARC) methods, implants, and IUDs, are assessed for cost-effectiveness, which compares cost-effectiveness in technology, environment, and health. The aim is to critically evaluate the economic evaluation of IUDs and implants based on previous scientific evidence, with a review to discuss cost-effectiveness.
Methods: The literature review used was a systematic review, and PRISMA-SR 2020 was chosen as a reference for preparing the literature study. The authors used three databases, PubMed, Science Direct, and Wiley, to find scientific evidence of the cost-effectiveness of IUDs and implants.
Results: The search in Pubmed (n=119), ScienceDirect (n=1,228), and Wiley (n=83) databases included (n=1,510) articles. Eighty-two articles were assessed for eligibility, and only seven were eligible according to the inclusion criteria for further review.
Conclusion: IUDs and implants are two highly effective long-term contraceptive methods for preventing pregnancy, so using IUDs is more cost-effective than implant contraception based on scientific articles that meet the inclusion criteria.
The relationship between peer interaction and adolescent’s dating behavior aged 15 – 24 years in Indonesia (IDHS 2017 analysis)
Authors: Fahdilla Noviyanti , Wahab Abdul , Padmawati Retna Siwi
Published: September 2024

Purpose: This study aims to determine the relationship between peer interaction and risky dating style behavior in adolescents aged 15-24.
Methods: A quantitative method using secondary data from the Indonesia Demographic and Health Survey (IDHS) 2017 with a cross-sectional study design. The research sample population used in this study includes male and female adolescents aged 15-24 years in Indonesia who are unmarried and currently or have been in a relationship.
Results: The behavior of adolescent dating style in Indonesia is in the low-risk dating style category, including holding hands and hugging. Bivariate analysis showed that there was a relationship between risky peer interactions and high-risk adolescent dating behavior, including kissing, touching and being touched on sensitive body parts, and sexual intercourse (p<0.05 and OR=1.42). The multivariable results showed that no external variables interfere with the relationship between peer interactions and dating style in adolescents. 
Conclusion: Peer interaction in risky reproductive health issues is associated with high-risk adolescent dating behavior, including kissing, touching sensitive areas, and sexual intercourse. Promotion and increasing education for adolescents related to reproductive health issues need to be done to minimize the incidence of high-risk dating styles among adolescents.
Factors influencing microplastic contamination in bottled drinking water in Indonesia: a systematic review
Authors: Amir Rahmi
Published: September 2024

Purpose: This study aimed to determine the content of microplastics in Indonesia, the factors that influence them, and their impact on the human body.
Methods: This study uses a qualitative method with a systematic literature review approach by reviewing eight journals screened using the prism method according to the inclusion criteria with a database derived from Science Direct, PubMed, Google Scholar, and the Invivo application.
Results: The results showed that the concentration of microplastics in bottled water was 7,043 - 8,339 particles/L with sizes ranging from small to large (10-5000 µm). The dominant form of microplastics was fibers and fragments, primarily white, with the dominant composition being polypropylene (PP), polyethylene (PE), and polyethylene terephthalate (PET) polymers. Factors affecting microplastics in bottled drinking water include water sources, production processes, exposure to sunlight, and repeated use of bottles. Microplastics can cause hormonal imbalances, heart disease, infertility risk, digestive disorders, and growth inhibition. Ways to reduce MP particles in AMDK include traditional filtering of raw water, electrocoagulation, magnetic extraction, and membrane separation.
Conclusion: This systematic literature review found that bottled drinking water in Indonesia contains 7,043 - 8,339 microplastic particles/L, primarily composed of PP, PE, and PET polymers. Factors influencing contamination include untreated waste disposal, high pollution levels, production processes, sunlight exposure, and repeated bottle use. These microplastics pose significant health risks, making it crucial to address these factors to reduce contamination and protect public health.
Compliance in medication control of hypertension patients during the transition period of the COVID-19 pandemic
Authors: Priscilla Hilary , Semiarty Rima , Masnadi Nice Rachmawati , Abdiana  , Fadrian
Published: September 2024

Purpose: This study aims to determine the relationship between adherence to medication control and blood pressure in hypertensive patients at the Talawi Public Health Center, Sawahlunto, during the transition period of the COVID-19 pandemic.
Methods: This observational analytic study with a cross-sectional design was conducted from May to June 2023 at the Talawi Public Health Center, Sawahlunto, with 83 research subjects. The research instrument used primary data from the MMAS-8 questionnaire with short interviews and secondary data in medical records of hypertension patients at the Talawi Public Health Center, Sawahlunto, in 2021–2023. The research results were analyzed by chi-square test.
Results: The results of this study were that the majority of hypertensive patients were not compliant in controlling their medication (65.1%), and the majority of hypertensive patients had uncontrolled blood pressure (61.4%).
Conclusion: This study concludes a significant relationship between adherence to medication control and blood pressure in hypertensive patients at the Talawi Public Health Center, Sawahlunto (p=0.041).
Desain Gamifikasi sebagai Pelengkap Aplikasi Pembelajaran Sistem Pendukung Keputusan Klinis
Authors: Dhias Muhammad Naufal  , Adhistya Erna Permanasari Permanasari  , Paulus Insap Santosa  , Silmi Fauziati  , Indriana Hidayah
Published: September 2024

Pada proses pembelajaran, pemberian materi pada siswa didukung peranan media pembelajaran. Implementasi konsep gamifikasi memperkaya media dan dapat meningkatkan minat siswa dalam penggunaan aplikasi tersebut. Penelitian ini mengembangkan media pembelajaran elektronik pada pengenalan materi sistem pendukung keputusan klinis atau clinical decision support system (CDSS). Pada dunia medis konsep CDSS cukup dikenal, sehingga pembelajaran ini kemudian diadopsi ke proses pembelajaran dalam bentuk mata kuliah. CDSS adalah sistem komputer untuk mendukung pengambilan keputusan dalam diagnosis dan pengobatan penyakit. Pada domain pembelajaran, kuliah CDSS ditawarkan pada mahasiswa klinis ataupun nonklinis. Aplikasi dikembangkan dengan metode feature-driven development serta menerapkan elemen gamifikasi seperti reward, challenge, dan leaderboard menggunakan kerangka kerja MDA. Proses pengembangan dimulai dari desain keseluruhan aplikasi dan penentuan tujuan pembelajaran, dilanjutkan dengan mendesain elemen gamifikasi yang cocok ke dalam desain keseluruhan aplikasi. Aplikasi yang dibangun  meliputi desain aplikasi, elemen gamifikasi, pengujian fungsionalitas, kebergunaan, dan pengalaman pengguna. Hasil akhirnya berupa suatu aplikasi Android. Pengujian fungsionalitas menggunakan pengujian black box mencapai hasil 100% kesesuaian. Uji pengguna menggunakan kuesioner system usability scale (SUS) dan user experience questionnaire (UEQ). Hasil pengujian menunjukkan skor SUS rata-rata 74,9 yang bermakna good dan skor UEQ mendapat nilai “Excellent”. Hasil penelitian menunjukkan bahwa penerapan gamifikasi pada pembelajaran CDSS dapat memperkaya fitur pendukung aplikasi pembelajaran. Elemen gamifikasi seperti hadiah, tantangan, dan leaderboard diharapkan menarik minat peserta didik untuk mempelajari serta aktif berpartisipasi dalam proses belajar. Aplikasi pembelajaran CDSS berpotensi meningkatkan motivasi dan keterlibatan peserta didik serta menciptakan pengalaman pembelajaran yang menarik dan efektif untuk peserta didik dari berbagai latar belakang.
Analisis Emisi Konduksi Perangkat Kompor Induksi di Frekuensi 150 kHz-30 MHz
Authors: Budi Sudiarto  , Henny Tri Kurniawati
Published: September 2024

Penggunaan kompor induksi di masa yang akan datang diprediksikan akan dapat menggantikan kompor jenis konvensional karena faktor keuntungan dari sisi efisiensi dan ketahanan energinya. Usaha konservasi energi tersebut juga merupakan upaya pemerintah dalam mengurangi krisis energi terkait penyediaan pasokan liquified petroleum gas (LPG). Namun, perangkat rumah tangga termasuk kompor induksi yang menggunakan teknologi inverter berpotensi menimbulkan gangguan elektromagnetik (electromagnetic interference, EMI) berupa emisi konduksi yang dapat diinterpretasikan sebagai arus derau yang merambat pada jalur konduksi dan berpotensi mengganggu peralatan elektronik lainnya melalui sumber tegangan. Penelitian yang dilakukan memiliki tujuan untuk mengidentifikasi sebaran perangkat kompor induksi sebagai salah satu jenis perangkat rumah tangga yang beredar di masyarakat terkait persyaratan gangguan elektromagnetik, yaitu emisi konduksi sesuai Comité International Spécial des Perturbations Radioélectriques (CISPR) 14-1:2020. Pengukuran emisi konduksi dilakukan terhadap empat merek kompor induksi yang beredar di masyarakat, yaitu merek A, C, M, dan P, dalam berbagai mode memasak dan level daya di rentang frekuensi 150 kHz-30 MHz, tegangan listrik PLN sebesar 220 V dan frekuensi 50 Hz. Pengukuran dilakukan sejumlah sepuluh kali untuk masing-masing tahap dan diambil enam nilai emisi konduksi tertinggi. Berdasarkan pengukuran, diperoleh hasil bahwa tingkat emisi konduksi pada sebagian besar kompor induksi yang dipergunakan dalam penelitian ini melampaui nilai yang dipersyaratkan dalam standar CISPR 14-1:2020. Komponen kompor induksi ke depannya harus lebih memperhatikan peraturan terkait emisi konduksi agar perangkat rumah tangga ini semakin aman serta nyaman bagi lingkungan elektromagnetik.
A Self-Adaptive Routing Region in Wireless Sensor Network’s Heterogeneous Traffic
Authors: Muhammad Nur Rizal  , P. Delir Haghighi
Published: September 2024

The paper presents a new routing scheme using the information on the locations of nodes to create a routing region that controls the region of packet routing to achieve route optimization. The proposed scheme aimed to reduce the occurrence of packet detours or other routing overheads caused by the undirected packet transmission. The strength of this approach is that it can improve the lifetime of nodes in the network while decreasing the time taken for a packet to arrive at its destination or base station (BS). The proposed scheme used a self-adaptive algorithm that dynamically adjusted the routing region based on the BS’s calculation of the network layer parameters to achieve energy efficiency while satisfying data quality. The routing region limits the area of routing and restricts data flooding in the entire network, which potentially will waste resources and cause data redundancy. The simulation showed that the proposed scheme outperformed, the original fitness scheme and SPEED, according to energy consumption, transmission delay, throughput, and reliability (packet delivery ratio) under different congestion levels. The proposed scheme offered double the throughput and shortened packet delay by 20%. Furthermore, it had a longer lifetime, exceeding other schemes by approximately twofold when the traffic was not too congested. However, the gap decreases when the network becomes worse.
Research and Practice of Blended Teaching Mode Based on Network Teaching Platform—Taking Engine Principles as an Example
Authors: Lin Xiaodan , Zhang Bin , Ma Shaohui
Published: September 2024

With the development of Internet information technology, a new educational model of “Internet + education” has emerged[1],It has promoted the reform of the university teaching classroom, and the hybrid teaching mode based on the online teaching platform will also enter the university classroom. In this paper, taking the engine principle course as an example, combines the school situation, teaching situation and learning situation of our school, and builds a hybrid teaching mode based on the online teaching platform. The construction and implementation of blended teaching mode are completed through the analysis of teaching content, teaching environment, teaching situation and teaching evaluation. It breaks the traditional teaching mode of teacher’s one-man show, realizes the dominant role of students and the leading role of teachers, stimulates students’ interest in learning, improves their independent learning ability, and ensures the quality of teaching.
MOLECULAR DOCKING OF BIFLAVONOIDS FROM GENUS ARAUCARIA AS DENV NS5 RNA-DEPENDENT RNA POLYMERASE INHIBITOR USING YASARA AND PLANTS PROGRAMS
Authors: AMBARSARI LAKSMI , NUR NAJMA AULIA , RODOTUL ZANAH SYIFA SILFANI , KURNIAWANTI  , DIANHAR HANHAN , WARNASIH SITI , CAHYANING RAHAYU DYAH UTAMI , SUGITA PURWANTININGSIH
Published: September 2024

Objective: This study aimed to screen 23 biflavonoids (23 BF) from the Araucaria genus to identify the most promising compound for anti-dengue fever antivirus treatment using in silico techniques with yet another scientific artificial reality application (YASARA) Structure and the Protein-Ligand ANT System (PLANTS) programs.
Methods: Predictions of conserved amino acids and potential pockets of the virus dengue NS5 RNA-dependent RNA polymerase (DENV NS5 RdRp) (PDB ID: 5K5M) were examined, while co-crystal ligands were prepared along with 23 biflavonoids. Molecular docking of ligands on the target protein was carried out using the YASARA Structure and PLANTS programs. The interactions were visualized with LigPlot+, Pymol, and Discovery Studio 2021 Client in. pdb format.
Results: The results showed that based on the molecular docking of 23 biflavonoids from the Araucaria genus against the selected DENV NS5 RdRp, the top nine compounds with great potential as antiviral drug candidates were identified. Among these compounds, 7,4’,7’’-tri-O-methylagathisflavone (BF3) was distinct as the best choice based on the analysis conducted using the YASARA Structure and PLANTS programs. Other compounds, including 7,4',4'''-tri-O-methylamentoflavone (BF10), 4',4'''-di-O-methylamentoflavone (BF11), 7,4',7'',4'''-tetra-O-methylamentoflavone (BF12), 7''-O-methylamentoflavone (BF13), and 7,7''-di-O-methylamentoflavone (BF14), were selected through the YASARA Structure program, while 7,4',7'',4'''-tetra-O-methylagathisflavone (BF8) and 7''-O-methylrobustaflavone (BF23) were selected from the PLANTS program. All compounds had lower free energy (∆G), dissociation constant (Kd), and docking scores compared to the reference ligand, balapiravir. Hydrogen and hydrophobic bonds were formed with the protein through conserved amino acid residues, the N-pocket, and the catalytic Gly-Asp-Asp (GDD) site.
Conclusion: The algorithm differences between the YASARA Structure and PLANTS programs led to the selection of the best compound 7,4',7''-tri-O-methylagathisflavone (BF3) as a candidate antiviral drug for dengue hemorrhagic fever.
LEVERAGING THE SUCCESS OF MRNA LIPID NANOPARTICLE VACCINE IN COVID-19 TREATMENT: A NARRATIVE REVIEW ON ITS POTENTIAL APPLICATION IN MALARIA TREATMENT
Authors: IHEAGWAM FRANKLYN NONSO , ADEDOYIN ENIOLA DEBORAH
Published: September 2024

Malaria, which is caused by the Plasmodium parasite and transmitted by mosquitoes, continues to be a major global health issue. The worldwide health community continues to work toward finding a conclusive answer to the malaria problem, but it is still elusive. Developing a successful malaria vaccine has proven difficult due to the Plasmodium parasite’s complicated life cycle and ability to change and develop resistance to interventions rapidly. Amidst this backdrop, the advent of mRNA Lipid Nanoparticle (mRNA-LNP) vaccines, exemplified by their resounding success in mitigating the Coronavirus Disease 2019 (COVID-19) pandemic, has kindled newfound hope in vaccine development. This review examines the potential of leveraging mRNA technology to induce a robust immune response, thereby potentially revolutionising the landscape of malaria prevention through the development of breakthrough malaria vaccines. The intricate interplay between the efficacy of the mRNA-LNP vaccine against COVID-19 and its prospective utility in addressing malaria is also deliberated upon.
DEVELOPMENT AND VALIDATION OF A SPECIFIC AND UNIQUE DUAL POLARITY ESI-LC-MS/MS METHOD FOR SIMULTANEOUS DETERMINATION OF SEMAGLUTIDE AND DAPAGLIFLOZIN IN HUMAN PLASMA
Authors: VATSAVAYI JAGAPATHI RAJU , REVU NALANDA BABY
Published: September 2024

Objective: To develop a method capable of simultaneous quantification and estimation of semaglutide and dapagliflozin which are being studied as a prospective combination therapy for treating Diabetes.
Methods: An intricate protein precipitation extraction technique was employed using verapamil and tolbutamide as internal standards for semaglutide and dapagliflozin, respectively. The two compounds were separated on a Kinetex C18 (50 mm x 2.1 mm, 5 µ Particle size) column, with a dual polarity ionization Electro Spray Ionization (ESI) on a Liquid chromatograph Tandem Mass Spectrometry (LC-MS/MS) instrument. The detection was carried out with a Multiple Reaction Monitoring (MRM) method, and a gradient program utilizing Acetonitrile and water as mobile phases to achieve a separation in 3 min.
Results: The method established was proved linear over a working range of 1.00 ng/ml to 1000 ng/ml and 2.00 ng/ml to 2000 ng/ml for semaglutide (r2>0.98) and dapagliflozin (r2>0.98) respectively in human plasma. The accuracy, recovery, and matrix effects were within acceptable limits. The stability was also established under various conditions as necessitated by the International Council for Harmonisation of Technical Requirements of Pharmaceuticals for Human Use (ICH) M10 guideline on Bioanalytical method validation.
Conclusion: This highly selective and sensitive method where 1.00 ng/ml for semaglutide and 2.00 ng/ml for dapagliflozin as the Lower Limit of Quantification (LLOQ) can be utilized for estimation in human plasma will facilitate the further application to pharmacokinetic and bioequivalence studies for combination of these two drugs in pharmaceutical dosage forms.