bluuebunny/crossref_metadata_2025 huggingface dataset:
Aflatoxin B1-DNA adducts modify the effects of post-operative adjuvant transarterial chemoembolization improving hepatocellular carcinoma prognosis
Authors: Huang Liyan , Long Qinqin , Su Qunying , Zhu Xiaoying , Long Xidai
Published: September 2023

Aim: In renal cell carcinoma (RCC), tumor heterogeneity generated challenges to biomarker development and therapeutic management, often becoming responsible for primary and acquired drug resistance. This study aimed to assess the inter-tumoral, intra-tumoral, and intra-lesional heterogeneity of known druggable targets in metastatic RCC (mRCC).
Methods: The RIVELATOR study was a monocenter retrospective analysis of biological samples from 25 cases of primary RCC and their paired pulmonary metastases. The biomarkers analyzed included MET, mTOR, PD-1/PD-L1 pathways and the immune context.
Results: High multi-level heterogeneity was demonstrated. MET was the most reliable biomarker, with the lowest intratumor heterogeneity: the positive mutual correlation between MET expression in primary tumors and their metastases had a significantly proportional intensity (P = 0.038). The intratumor heterogeneity grade was significantly higher for the mTOR pathway proteins. Combined immunophenotypical expression patterns and their correlations with the immune context were uncovered [i.e., mTOR expression in the metastases positively correlated with PD-L1 expression in tumor-infiltrating lymphocytes (TILs), P = 0.019; MET expression was related to PD-1 expression on TILs (P = 0.041, ρ = 0.41) and peritumoral lymphocytes (RILs; P = 0.013, ρ = 0.49)], suggesting the possibility of predicting drug response or resistance to tyrosine kinase, mTOR, or immune checkpoint inhibitors.
Conclusions: In mRCC, multiple and multi-level assays of potentially predictive biomarkers are needed for their reliable translation into clinical practice. The easy-to-use immunohistochemical method of the present study allowed the identification of different combined expression patterns, providing cues for planning the management of systemic treatment combinations and sequences in an mRCC patient population. The quantitative heterogeneity of the investigated biomarkers suggests that multiple intralesional assays are needed to consider the assessment reliable for clinical considerations.
On the Need for a Unified Concept of the Share from the Standpoint of Legal and Individual Regulation of Legal Relations of Common Ownership
Authors:   Twenty-First Arbitration Court of Appeal, Sevastopol, Russia, Zarubin Aleksey V.
Published: September 2023

One of the most complex civil law relations are the relations of common shared ownership, which is due to the presence of such an object as a share in them. The integrity of the relations of common shared ownership should be ensured by a common understanding of the share in the law and judicial practice, without which a harmonious combination of legal and individual regulation of these relations is impossible. The purpose of the study is to find out whether the share is equally understood in law and judicial practice, and whether there is a need to develop a unified concept of the share from the standpoint of individual and legal regulation of legal relations of common ownership. To achieve this goal, a number of tasks have been solved: the current civil legislation in the part containing the definition of the share has been analyzed; judicial practice has been summarized in the same part and the scientific literature has been reviewed. Accordingly, methods of analysis, synthesis, generalization, induction, and comparison were used. In conclusion, it is concluded that the law and judicial practice understand the share in the right of common ownership differently. The law establishes that the share is part of the right, but at the same time indicates the share as an ideal part of the thing. Judicial practice adds that a share can be a thing (a real part of a thing) or a part of the value. This state of affairs testifies to the discord between the legal and individual regulation of the studied relations, which is theoretically unacceptable and practically counterproductive. In this regard, the science of civil law has a task: to develop a unified concept of a share that would not relate to the concept of a “share in the right”, “a real or ideal part of a thing”, as well as a “share in value”, since they have not fulfilled their task of creating a coherent structure of shared ownership relations.
Reasonable Risk and the Exercise of Professional Functions as Circumstances Precluding the Criminality of an Act: Characteristics of Similarities and Differences, Features of Interaction
Authors:   Russian State University of Justice, Moscow, Russia, Talaev Ilya V.
Published: September 2023

The article presents a comparative characteristic of the circumstance fixed in Article 41 of the Criminal Code of the Russian Federation, excluding the criminality of the act: “reasonable risk”, and the circumstance existing in the theory of criminal law, excluding the criminality of the act: “causing harm in the exercise of professional functions”. The specifics of their interaction in the conditions of military service are also considered. The conclusion is made about the close relationship of these circumstances, which can be characterized as intersecting Euler circles.
Features of Consideration of Disputes on Value Added Tax in Bankruptcy Legal Relations
Authors:   Volga Branch, Russian State University of Justice, Nizhny Novgorod, Russia, Popkova Zhanna G. , Rashidov Omar Sh.
Published: September 2023

In historical retrospect, the article examines some aspects of the regulation of the payment of value added tax by entities recognized as bankrupt, taking into account the practice of the highest judicial authorities, as well as in terms of the reaction of the legislator to these legal problems. Conclusions are drawn that the studied issues allow us to see the competition of opposing values expressed, on the one hand, in national legal acts on taxes; and, on the other hand, in national legal acts on bankruptcy. The legislator as a result from January 1, 2021 chose the path of complete exclusion of value-added tax on any assets sold by a bankrupt.
Exclusive Right in the Theory of Absolute Subjective Civil Rights
Authors:   Peoples' Friendship University of Russia, Moscow, Russia, Petkilev Pеtr I.
Published: September 2023

Exclusive rights to various objects of intellectual property rights differ significantly from each other, which allows us to talk about their diversity. The research is aimed at studying the legal nature of exclusive rights. In particular, attention is paid to the attribute of the absoluteness of exclusive rights. The paper consistently argues for the need to rethink the sign of absoluteness of exclusive rights. The author comes to the conclusion that not all exclusive rights are absolute. This conclusion determines the need to formulate new classifications of subjective civil rights. Keywords: exclusive rights, subjective law, absolute law, dichotomy of law
Contract for the Manufacture of Medicines
Authors:   Russian State University of Justice, Moscow, Russia, Sheludyaev Vladislav V.
Published: September 2023

The article is devoted to determining the place of the contract for the manufacture of medicines in the civil contract system. For these purposes, the author has studied the signs of a contract for the manufacture of medicines, according to the totality of which, the author comes to the conclusion that the contract must be qualified as a household contract. The author considers the specifics of the legal regulation of the contract for the manufacture of medicines due to the specifics of the object of the contract – medicines. The result of such legal regulation is the impossibility of the parties to the contract to implement a whole group of rights.
About the Justice of Modern Justice
Authors:   Central Branch, Russian State University of Justice, Voronezh, Russia, Kombarova Elena L.
Published: September 2023

The article analyzes the problems of justice of modern criminal justice. Various interpretations of the category “justice” are considered. The conclusion is formulated about the need to form a new methodological concept that develops algorithms for analyzing judicial activity in the field of criminal proceedings from the standpoint of criminology based on an integrative approach. Situational analysis of judicial evidence will allow to form effective methodological and tactical recommendations that contribute to improving the quality of epistemological research by a judge of the actual circumstances of a criminal event, increasing the level of public confidence in the judicial system, assessing justice as fair. The article also reflects the author’s vision of the impact of the informatization process on judicial activity. The thesis has been formed that online justice is a utopia, virtual technologies hinder the knowledge of objective truth, reduce the degree of justice.
Pemberdayaan Guru dan Orang Tua tentang Penanganan Kegawatdaruratan Rongga Mulut Anak Pra Sekolah
Authors: Putranto Ricky Anggara , Theresia Tiarma Talenta , Budiman Johan Arief , Suwartini Tien , Pakpahan Alfred
Published: September 2023

Oral emergencies are trauma involving the teeth and the supporting structures of the teeth. This trauma can be in the form of open wounds, broken teeth and loose teeth. During the COVID-19 pandemic, mothers had more time to spend with their children, so they were expected to be able to provide quick and appropriate action if their children experienced trauma to their teeth. This empowerment activity aims to increase knowledge and skills in handling oral emergencies. This Community Service activity was carried out by the Trisakti University Faculty of Dentistry Team for Teachers and Parents of Kindergarten Al Hidayah 2 Kelapa Gading on December 1, 2022. Counseling and training were carried out offline using presentations on open wounds, broken teeth loose teeth, and first aid that can be done at home. Training and counseling was carried out to 46 participants for 60 minutes. Participants' knowledge was assessed by pre-test and post-test using Google Form. From the results obtained, it was seen that there was an increase in the knowledge of the counseling participants by 13.5% (mean pre-test score was 28.9 ± 14.6 and mean post-test score was 68 ± 15.3).
Peningkatan Pengetahuan dan Ketrampilan Ibu Menyusui dengan Simulasi Modelling Digital Kontrasepsi Suntik di Klinik Permata Hati Karanganyar
Authors: Wati Erna , Eka Widyastuti Deny , Umarianti Tresia , Rohmatika Dheny
Published: September 2023

Breastfeeding is natural process that is not easy. The coverage of exclusive breastfeeding cannot be separated from the problems that occur in the breastfeeding process, including the wrong assumption that little milk comes out or breast milk not sufficient for the baby's needs. This condition is caused by several factors, including the food and drink consumed by the mother, psychological or emotional condition of the mother, and abnormal breast shape. A new method introduced to prevent and overcome this problem Digital Modeling Simulation of Injecting Contraception at the Permata Hati Clinic in Karanganyar. Purpose To find Injecting Contraceptive Digital Modeling Simulation at Permata Hati Clinic Karanganyar. The result of community service is that breastfeeding mothers at the Permata Hati Karanganyar clinic have increased the knowledge and skills of breastfeeding mothers with digital modeling simulations for injecting contraceptives at the Permata Hati Karanganyar Clinic. Increased knowledge 2 through digital modeling simulations, which initially was 13.6 increased to 15.6 and there was increased in breastfeeding. Based on the implementation of community service, it can concluded that there is an increase in the behavior of postpartum mothers in the use of contraceptives and the breastfeeding process.
Active seniors participating in Pilates Exploring leisure savoring beliefs, Ways of Savoring, and meaning of life
Authors:   Korean Society for Leisure Scie, Lim Yoon-Kyung , Kang Hyun-Wook
Published: September 2023

The purpose of this paper was to explore the leisure enjoyment beliefs, enjoyment methods, and meaning of life of active seniors participating in Pilates. A grounded theory approach was used as a research method. The subjects were 8 people who participated in Pilates for more than 2 years in Seoul and Gyeonggi-do. After collecting the enjoyment beliefs and enjoyment methods of the active seniors, the study subjects, the data from the in-depth interviews were continuously analyzed according to the procedures of open coding, axial coding, and selective coding using the grounded theory approach. Therefore, it was confirmed that active senior women participating in Pilates lead a satisfactory life through their own healthy activities before entering middle age or old age, and expand the meaning of life by harmonizing their beliefs and ways of enjoying physically and mentally.
Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells
Authors: Wu Ying , Yin Ai-Hong , Sun Jun-Tao , Xu Wei-Hua , Zhang Chun-Qing
Published: September 2023

Delayed passage of meconium or constipation during the perinatal period is traditionally regarded as a signal to initiate further work up to evaluate for serious diagnoses such as Hirschsprung’s disease (HD), meconium ileus due to Cystic Fibrosis, etc. The diagnosis of HD particularly warrants invasive testing to confirm the diagnosis, such as anorectal manometry or rectal suction biopsy. What if there was another etiology of perinatal constipation, that is far lesser known? Cow’s milk protein allergy (CMPA) is often diagnosed in infants within the first few weeks of life, however, there are studies that show that the CMPA allergen can be passed from mother to an infant in-utero, therefore allowing symptoms to show as early as day one of life. The presentation is more atypical, with perinatal constipation rather than with bloody stools, diarrhea, and vomiting. The diagnosis and management would be avoidance of cow's milk protein within the diet, with results and symptom improvement in patients immediately. Therefore, we discuss whether an alternative pathway to address perinatal constipation should be further discussed and implemented to potentially avoid invasive techniques in patients. This entails first ruling out CMPA with safe, noninvasive techniques with diet modification, and if unsuccessful, then moving forward with further diagnostic modalities.
Carcinoid syndrome caused by a pulmonary carcinoid mimics intestinal manifestations of ulcerative colitis: A case report
Authors: Reyes Carmen Mota , Klein Henriette , Stögbauer Fabian , Einwächter Henrik , Boxberg Melanie , Schirren Moritz , Safi Seyer , Hoffmann Hans
Published: September 2023

Delayed passage of meconium or constipation during the perinatal period is traditionally regarded as a signal to initiate further work up to evaluate for serious diagnoses such as Hirschsprung’s disease (HD), meconium ileus due to Cystic Fibrosis, etc. The diagnosis of HD particularly warrants invasive testing to confirm the diagnosis, such as anorectal manometry or rectal suction biopsy. What if there was another etiology of perinatal constipation, that is far lesser known? Cow’s milk protein allergy (CMPA) is often diagnosed in infants within the first few weeks of life, however, there are studies that show that the CMPA allergen can be passed from mother to an infant in-utero, therefore allowing symptoms to show as early as day one of life. The presentation is more atypical, with perinatal constipation rather than with bloody stools, diarrhea, and vomiting. The diagnosis and management would be avoidance of cow's milk protein within the diet, with results and symptom improvement in patients immediately. Therefore, we discuss whether an alternative pathway to address perinatal constipation should be further discussed and implemented to potentially avoid invasive techniques in patients. This entails first ruling out CMPA with safe, noninvasive techniques with diet modification, and if unsuccessful, then moving forward with further diagnostic modalities.
RANCANG BANGUN PENJADWALAN JASA MAKEUP ARTIST (MUA) BERBASIS WEB MENGGUNAKAN ALGORITMA GENETIKA (AG) PADA KLABERSMUA
Authors: Anatasya A.Edeth Fuari
Published: September 2023

ABSTRAK

KlabersMUA merupakan salah satu penyedia layanan jasa Makeup. Layanan jasa makeup pada KlaberMUA masih menggunakan sms dan telepon sebagai media komunikasi antara pelanggan dan perias, masalah lain yang di rasakan MUA yaitu pengaturan jadwal yang menumpuk karena banyak pelanggan yang meminta pada jadwal yang sama sehingga tidak jarang terjadinya jadwal bertabrakan[1][2]. MUA juga seringkali harus melayani pelanggan yang terlanjur datang ke lokasi lebih dari target yang seharusnya. Tujuan dari penelitian ini adalah untuk merancang Sistem Penjadwalan Jasa MakeUp Artis menggunakan Algoritma Genetika. Algoritma yang digunakan dalam menyelesaiakan permasalahan tersebut adalah Algoritma Genetika. Untuk desain penelitian yang digunakan adalah UML yang terdiri dari Usecase Diagram, Activity Diagram, Sequence Diagram, sedangkan Bahasa Pemrograman yang digunakan dalam membangun sistem ini adalah Bahasa Pemrograman PHP dan MySql untuk pengolahan database[3][4]. Hasil penelitian ini adalah sistem mampu membantu pelanggan dalam melakukan pemesanan jasa makeup dan juga membantu KlaberMUA dalam mengatur jadwal makeup. Berdasarkan hasil pengujian sistem dengan kuesioner kepada beberapa pengguna sistem, di hasilkan 85% sangat layak dalam kemudahan akses, 77,5 % sangat layak dalam kesesuaian output, 67,5 % layak dalam proses pengolahan data, 82,5% sangat layak dalam kemudahan pemesanan dan 82,5% sangat layak dalam menghindari terjadinya jadwal pelanggan yang bertabrakan .
SISTEM INFORMASI PEMESANAN BAJU CAP KARUNG PADA TOKO PASHA PUSAT NIAGA PALOPO
Authors: Mukarramah Andhini Rezki , Laswi Aishiyah Saputri , Muhallim Muhlis
Published: September 2023

Sistem informasi pemesanan baju cap karung merupakan sebuah sistem yang memberikan pelayanan dalam pemesanan baju bekas atau yang selama ini disebut dengan baju cak karung. Baju cap karung merupakan baju bekas yang didatangkan dari luar negeri menggunakan karung cukup diminati warga palopo. Tujuan penelitian ini adalah membuat sebuah aplikasi toko online berbasis android agar dapat membantu mempromosikan produk yang ada pada Toko Pasha, metode pengembangan yang digunakan adalah dengan menggunakan metode waterfall, lalu hasil dari penelitian ini adalah berhasil membuat sebuah aplikasi toko online untuk mempermudah para pelaku usaha untuk mempromosikan produknya dan untuk mempermudah konsumen dalam melakukan pemenasan tanpa harus datang langsung ketempatnya, aplikasi yang dibuat sudah di uji menggunakan metode blackbox testing sehingga aplikasi yang dibuat sudah tidak ada lagi kesalahan fungsi sistem, Hasil pengujian usability yang dilakukan responden yang berjumlah 15 orang pembeli dan membagikan kuesioner dengan skor 81,11% sangat setuju dalam mempermudah dalam pemesanan.
Penerapan Profesionalisme Prinsip-Prinsip MSDM Dan Pemasaran Untuk Peningkatan Mutu Sekolah Yayasan Satiahardja Kota Bogor
Authors: Sujana Sujana , Zuhdi Saefudin , Nurjanah Yayuk
Published: September 2023

Tujuan penyelenggaraan kegiatan Penerapan Profesionalisme Prinsip-Prinsip MSDM dan Pemasaran Demi Mutu Sekolah Yayasan Satiahardja Kota Bogor, Membuat, mengedit, brainstorming, menerapkan dan mengevaluasi pedoman (1) kerja kebijakan dan prosedur kesiswaan (2) kerja kebijakan dan prosedur organisasi (3) kerja kebijakan dan prosedur kepegawaian Sekolah Kemuning. Diharapkan hasil PKM ini dapat dijadikan sebagai acuan dan pedoman bagi kepala sekolah, guru-guru dan tenaga kependidikan pada institusi ini. Keberhasilan dari naskah dokumen harus diketahui dan dipahami oleh seluruh pegawai, untuk itu masing-masing unit melakukan sosialisasi atau pembahasan, secara rutin dan bertahap. Kinerja pengabdian kepada masyarakat (PKM) untuk output yang dihasilkan proyek ini sebesar 94,87%, merupakan angka rasio antara harapan dan kinerja.

 

Kata Kunci:  Brainstorming, Kebijakan, Prosedur dan Kinerja
PKM Penyuluhan Tren UMKM di Era Industri 4.0
Authors: Satria Wahyu Indra , Zulkarnain Pingky Dezar , Effendy Marwan
Published: September 2023

Usaha mikro, kecil, dan menengah menjadi salah satu hal penting dalam aspek pertumbuhan ekonomi Indonesia. Pemerintah Indonesia selaku pengatur resmi regulator usaha mikro, kecil, dan menengah, berperan aktif dalam membantu memajukan UMKM di Negara Indonesia. Kemajuan teknologi informasi yang berkembang diera indstri 4.0 sekarang, juga menjadi salah satu komponen penting bagi tren perkembangan UMKM di Indonesia. Adapun pengaruh dari teknologi informasi pada tren keberlangsungan keadaan UMKM di Indonesia tersebut, dapat berupa dampak positif dan negatif dari era industri 4.0. Mengacu pada keadaan tersebut, maka pentingnya memberikan penyuluhan edukasi, sosialisasi dan knolwdge terbarukan kepada masyarakat, mengenai tren keadaan keberlangsungan UMKM Indonesia di era industri 4.0 saat ini, untuk membantu keberlangsungan UMKM Indonesia. Dengan penyuluhan berdasarkan 5 (Lima) pilar utama dalam industri 4.0 yang dikombinasikan dengan GE Matriks, diharapkan dapat membantu Tim Abdi Masyarakat memberikan signifikansi edukasi, sosialisasi beserta knowledge terbarukan bagi masyarakat, dalam menghadapi juga membantu tren keberlangsungan keadaan UMKM di Indonesia.

 

Kata Kunci : UMKM, Industri 4.0., GE Matrix.
Sosialisasi Pengenalan Instrumen Investasi Reksa Dana Kepada Pegawai PT. Reasuransi Nasional Indonesia
Authors: Alamsyah Richad , Srihandoko Wimpi , Taqyuddin Yudin
Published: September 2023

Ditengah krisis pandemi covid-19 pengenalan serta edukasi pasar modal sebagai salah satu faktor penting dalam berinvestasi bagi pegawai PT. Reasuransi Nasional Indonesia yang  bertujuan mengedukasi pegawai agar lebih mengenal instrumen serta literasi investasi khususnya reksa dana, sehingga diharapkan pegawai dapat tertarik mengikuti edukasi literasi investasi pasar modal dan berminat untuk memulai investasi ditengah kondisi pandemi yang selanjutnya dapat diaplikasikan dalam kehidupan sehari-hari dalam mengatur keuangan masing-masing pegawai.

   Metode pelaksanaan kegiatan pengabdian dilakukan dengan aplikasi zoom atau online yaitu pegawai diberikan pembelajaran pengenalan investasi pasar modal khususnya reksa dana, literasi keuangan, dan perlunya memulai investasi sesegera mungkin, diskusi dan tanya jawab mengenai literasi investasi reksa dana serta evaluasi kegiatan.

Hasil kegiatan pengabdian, adanya peningkatan pengetahuan dan pemahaman literasi investasi reksa dana dikalangan pegawai PT. Reasuransi Nasional Indonesia baik usia milenial maupun non milenial dan permintaan pendampingan pemahaman lebih lanjut mengenai literasi dan cara berinvestasi di reksadana.   

 

Kata Kunci : Investasi Reksa Dana, Pasar Modal, Pegawai
Pemanfaatan Digital Marketing UMKM Berbasis Kearifan Lokal Batik Bogor Melalui Media Sosial
Authors: Cahyani Nani
Published: September 2023

Program pengembangan UMKM yang diuusulkan dengan mengusung tema pemanfaatan digital marketing UMKM berbasis kearifal lokal batik Bogor melalui media sosial untuk para pelaku usaha dan pengrajin batik yang berada di Kampung Batik Cibuluh memiliki potensi yang luar biasa tinggi dan dapat dikembangkan menjadi suatu produk kerajinan berbasis kearifal local Bogor  dan destinasi wisata kota Bogor. Program ini diusulkan berdasarkan adanya permasalahan para pelaku usaha batik yang tergabung dalam komunitas kampung batik Bogor mempunyai pengetahuan dan skills yang kurang memadai terhadap digital marketing sebagai sarana dalam memasarkan produk mereka, sehingga sulit untuk meningkatkan omzet penjualannya.  Sementara digital marketing saat ini bisa dikatakan  sebagai sarana yang paling utama dalam proses mempromosikan produk. Tujuan dari program kegiatan PKM ini adalah untuk memberikan solusi terhadap  permasalahan turunnya omzet di kalangan pelaku usaha batik, melalui pelatihan pemanfaatan digital marketing maka diharapkan  para pelaku usaha mampu untuk meningkatkan pemahaman dan ketrampilannya  dalam memasarkan produk dan meningkatkan omzet penjualan secara efektif dan efisien, disamping itu kegiatan ini mampu menghasilkan luaran PKM yang dapat digunakan dalam meningkatkan kompetensi dosen dan mahasiswa dalam proses belajar mengajar serta berkontribusi secara langsung dalam pembangunan masyarakat Kota Bogor.
PKM PENDAMPINGAN PENGENDALIAN INTERNAL PIUTANG MENGURANGI PIUTANG TAK TERTAGIH BAGI KARYAWAN PT ENSEVAL PUTERA MEGATRADING CABANG BOGOR
Authors: Rachman Rachmawaty
Published: September 2023

In facing competition and wanting to increase the number of sales, companies can sell their goods by credit to their customers. The existence of this credit sale will give rise to receivables (receivables), which will receive payment at maturity. The longer or longer the period for payment of receivables, will increase the period for collection of these receivables. Receivables are elements of working capital that are always rotating continuously, in which only one step is receivables turning into cash. The problem of accounts receivable is considered important in relation to the company, because the company must determine what the optimal amount of receivables is. Receivables must also manage efficiently related profits or additional profits obtained by changes in sales policies with expenses incurred due to receivables. Internal control systems include the organizational structure, and all coordinated methods and tools used within the company with the aim of maintaining the security of company assets, checking the accuracy and correctness of accounting data, promoting efficiency in operations and helping to maintain the management policies that have been adhered to previously set. .

Keywords: Receivables, Internal Control
PSICOTERAPIA EMBALADA PELO CONTEXTO PSICOLÓGICO: INFLUÊNCIAS DA EVOLUÇÃO TECNOLÓGICA NA COMPOSIÇÃO MENTAL E NAS ESTRATÉGIAS PSICOTERAPÊUTICAS
Authors: Gomes Caio Cesar Piffero
Published: September 2023

Este artigo investiga a ação do contexto social na composição mental por influência do avanço tecnológico, levando em consideração o acompanhamento de pacientes em psicoterapia em consultório privado. Com o imprescindível avanço tecnológico da psicoterapia, a mesma objetiva relacionar o uso de tecnologias avançadas, como as utilizadas na comunicação virtual e no trabalho remoto, enquanto estratégia usada por psicólogas(os), para o tratamento da saúde mental, considerando que diferentes demandas de saúde mental têm adentrado aos consultórios, supostamente, decorrentes de influências dos referidos instrumentos. Constata que o contexto social permeado por tecnologias de estrema complexidade, na proporção em que estão massivamente disponibilizadas à população, estimula rápidas alterações na composição mental, na medida em que atravessa diversas áreas de convívio em sociedade. A utilização de tais instrumentos tem sido inevitável, porque eles estão presentes nos afazeres contemporâneos e, para utilizá-los são necessárias constantes e novas aprendizagens, desencadeando possibilidades de estresse, inquietações e desconfortos psicológicos, capazes de provocar desadaptações mentais. O psicoterapeuta, inserido no mesmo contexto, fica obrigado a utilizar os mesmos instrumentos e tecnologias, tanto para a sua adaptação social como para obter bom desempenho profissional. O contexto contemporâneo caracterizado por rápidas mudanças, favorece que as pessoas tendam acompanhar o ritmo das inovações, notado pelas substituições de um aparelho novo por outro ainda mais moderno, com novidades operacionais mais sofisticadas do que as existentes no anterior. A utilização de estratégias e de técnicas psicoterápicas variam entre uma época e outra e, com o passar do tempo, podem não mais ter a eficiência desejada, pois com a atualização dos canais de comunicação, a capacidade de entendimento entre os interlocutores – pacientes e psicoterapeutas –, pode ser comprometida. Podem ter sido eficazes em época anterior, apresentar problemas no presente, assim como não ter mais o mesmo desempenho, em época futura. Averígua-se, como possíveis instrumentos psicoterápicos auxiliares do psicoterapeuta, o uso colaborativo de recursos tecnológicos como os algorítmicos e a inteligência artificial.
DESEMPENHO REPRODUTIVO DE LEITOAS DE ORIGEM QUARTO SÍTIO ALOJADAS EM SISTEMA ELECTRONIC SOW FEEDING
Authors: Erbes Laura Camila , Rossi Carlos Augusto , Rodrigues João Victor Facchini , Erbes André Rogério , Wilsmann César Gustavo , Ditadi Cassiane Turchetto
Published: September 2023

As leitoas de reposição compõem uma categoria de fundamental importância e representam entre 17 a 21% do grupo de parição. O presente trabalho objetivou avaliar o desempenho reprodutivo de leitoas de reposição origem quarto sítio e alojadas em sistema Electronic Sow Feeding, a ocorrência de mumificação fetal em leitegadas maiores que 12 leitões, o status de treinamento e alojamento, e a influência da máquina de alimentação tonta ou eletrônica sobre a mumificação fetal. Foram utilizadas 158 fêmeas gestantes da genética Camborough® inseminadas em quarto Sítio e transferidas para a Unidade de Produção de Desmamados (UPD) com 36±1 dias de gestação. As leitoas apresentaram em média 15,45±3 leitões, sendo 14,18±3 leitões nascidos vivos, 0,54±0,79 leitões natimortos e 0,74±1,49 leitões mumificados. Observou-se diferença estatística (P<0,05) entre a quantidade de leitões mumificados nas matrizes com leitegadas maiores que 12 leitões, ocorrendo em 35% das leitoas. Em relação ao treinamento das fêmeas, 97,5% foram consideradas treinadas. Além do status de treinamento, 94,80% das matrizes treinadas foram alojadas em ESF, 2,5% foram alojadas em celas individuais, 1,9% vieram a óbito e 3,20% foram retiradas das baias por alterações do aparelho locomotor. Não houve diferenças (P>0,05) entre o efeito das máquinas de tratamento eletrônica e tonta sobre a quantidade de leitões mumificados. A mumificação fetal não pode ser relacionada apenas às estações de alimentação, visto que o sistema ESF tem como intuito proporcionar maior liberdade as matrizes frente a necessidade de alimentação, além de facilitar o arraçoamento dos animais.
DESENVOLVIMENTO ECONÔMICO: REGULAÇÃO COMO INSTRUMENTO DE ORDENAÇÃO DO MERCADO BRASILEIRO
Authors: OLIVEIRA Jeferson S , CARDOSO Carlos Henrique Baptista , OLIVEIRA Cristiano de
Published: September 2023

Ante o fortalecimento do mercado com o despontar da globalização, definir os limites da atuação dos agentes econômicos se tornou uma necessidade a fim de impedir a ocorrência de abusos ao poder econômico e garantir o desenvolvimento do Estado a partir do mercado. Assim, presente trabalho almeja tratar da importância da atividade regulatória para a ordenação do mercado, haja vista sua essencialidade para o desenvolvimento do Estado em meio à globalização. Para tanto, vale-se do método hipotético-dedutivo, a partir de revisão bibliográfica e análise legislativa.
PRESSUPOSTOS BÁSICOS DA TERAPIA COGNITIVO-COMPORTAMENTAL NA PRÁTICA CLÍNICA
Authors: POISK Camilla Casotti , RAMOS Djonathan Felipe , AMARAL Edina
Published: September 2023

A Terapia Cognitivo-Comportamental é uma abordagem psicológica relativamente nova, constituída por Aaron Beck e embasada no princípio de que o pensamento é o cerne dos transtornos psicológicos, considerando que os pensamentos influenciam as emoções e os comportamentos. Logo, é necessária a modulação dos pensamentos disfuncionais para a conquista de mudanças emocionais e comportamentais duradouras, possibilitando a melhora e alívio dos sintomas. Tendo isso em vista, o presente artigo consiste em uma revisão bibliográfica que irá explanar acerca dos pressupostos teóricos, conceitos centrais e intervenções básicas da Terapia Cognitivo-Comportamental na prática clínica, que embora seja estruturada, preza pela empatia e calor humano da relação terapêutica para a promoção da qualidade de vida e bem-estar dos pacientes.
A TECNOLOGIA DA INFORMAÇÃO E COMUNICAÇÃO NO PROCESSO DE ENSINO DA MATEMÁTICA: REFLEXÕES TEÓRICAS
Authors: Braun Layane Caroline Silva Lima , Lopes Arleson Eduardo Monte Palma
Published: September 2023

Objetivo geral do artigo é propor uma reflexão teórica da contribuição do uso das Tecnologias de Informação e Comunicação no ensino de matemática, sendo norteado pelo seguinte questionamento: como o uso das TIC’s contribuem para o ensino da matemática? As TIC’s podem oferecer para o desenvolvimento das atividades cotidianas, tecnológicas e pedagógicas no ambiente escolar, ressaltando a importância e a utilidade que as TIC’s possuem no processo de ensino-aprendizagem em matemática, pois viabiliza a execução das informações e o conhecimento, gerando resultados no processo, na concepção, na interpretação e na investigação informacional, assim, colaborando para a construção do conhecimento do discente que acaba originando novas estratégias e possibilidades de solucionar soluções-problemas do seu dia a dia e da matemática e aos docentes mais uma ferramenta metodológica para o ensino da matemática.
Beneficios de la estimulación temprana en la prevención de alteraciones del neurodesarrollo en los primeros mil días: una revisión narrativa
Authors: Rios-Castillo Israel , Pineda A. Ana Karina
Published: September 2023

Las alteraciones del neurodesarrollo en la primera infancia tienen una alta prevalencia a nivel mundial, representando un desafío para los especialistas porque deben lograr minimizar alteraciones en el niño desde la etapa prenatal. El objetivo de esta revisión es realizar un análisis narrativo de la evidencia disponible sobre el neurodesarrollo y el impacto positivo que tiene la estimulación temprana, particularmente durante los primeros mil días de vida, en la prevención de alteraciones del neurodesarrollo. Existen diversas pruebas estandarizadas de cribado del desarrollo infantil, para identificar posibles signos de alarma en el neurodesarrollo como la BINS, PRUNAPE, ASQ-3, Test de Denver, entre otras. Una de las alternativas de tratamientos no invasivos para tratar y prevenir alteraciones en el niño es la estimulación temprana. A través de la intervención integral en el niño se logra adquirir, compensar y/o potencializar las habilidades del neurodesarrollo; dando como resultado un ser adaptado al medio que lo rodea. Es importante diseñar y validar una guía integral para la vigilancia del neurodesarrollo infantil, desde la etapa prenatal para la prevención de alteraciones o evitar secuelas en el niño; así como diseñar políticas públicas que promuevan una adecuada infancia.
Protective Effects of Melatonin in High-Fat Diet-Induced Hepatic Steatosis via Decreased Intestinal Lipid Absorption and Hepatic Cholesterol Synthesis
Authors: Ku Hyungjune , Kim Yeonji , Kim Alvin Lyle , Lee Garam , Choi Youngsik , Kim Bukyung
Published: September 2023

Background: The preventative effect of melatonin on the development of obesity and the progression of fatty liver under a high-fat diet (HFD) has been well elucidated through previous studies. We investigated the mechanism behind this effect regarding cholesterol biosynthesis and regulation of cholesterol levels.Methods: Mice were divided into three groups: normal chow diet (NCD); HFD; and HFD and melatonin administration group (HFD+M). We assessed the serum lipid profile, mRNA expression levels of proteins involved in cholesterol synthesis and reabsorption in the liver and nutrient transporters in the intestines, and cytokine levels. Additionally, an in vitro experiment using HepG2 cells was performed.Results: Expression of hepatic sterol regulatory element-binding protein 2 (SREBP-2), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), and low-density lipoprotein receptor (LDLR) demonstrated that melatonin administration significantly reduces hepatic cholesterol synthesis in mice fed an HFD. Expression of intestinal sodium-glucose transporter 1 (SGLT1), glucose transporter 2 (GLUT2), GLUT5, and Niemann-pick C1-like 1 (NPC1L1) demonstrated that melatonin administration significantly reduces intestinal carbohydrate and lipid absorption in mice fed an HFD. There were no differences in local and circulatory inflammatory cytokine levels among the NCD, HFD, and HFD+M group. HepG2 cells stimulated with palmitate showed reduced levels of SREBP, LDLR, and HMGCR indicating these results are due to the direct mechanistic effect of melatonin on hepatocytes.Conclusion: Collectively, these data indicate the mechanism behind the protective effects of melatonin from weight gain and liver steatosis under HFD is through a reduction in intestinal caloric absorption and hepatic cholesterol synthesis highlighting its potential in the treatment of obesity and fatty liver disease.
Hastanelerde Çalışan Hemşirelerin Atalet Durumlarının Kaçırılmış Hemşirelik Bakımı ile İlişkisi
Authors: UYURDAĞ Nermin , YILDIRIM Aytolan
Published: September 2023

Amaç: Bu çalışmanın amacı hemşirelerin atalet ve karşılanamayan hemşirelik bakım düzeylerinin ve bu düzeyler arasındaki ilişkinin belirlenmesidir.
Yöntem: Tanımlayıcı ve ilişki arayıcı tarzda gerçekleştirilen bu çalışma Diyarbakır merkezdeki bir devlet üniversitesi, bir eğitim araştırma ve bir özel hastanede çalışan hemşireler (N=1694) içinden oransal tabakalı örneklem yöntemi ile belirlenen 413 hemşire ile gerçekleştirilmiştir. Veriler Tanıtıcı Bilgi Formu, Atalet Ölçeği ve Karşılanamayan Bakım Ölçeği ile Mart-Kasım 2020 tarihleri arasında toplanmıştır. Verilerin analizde, normallik testleri, güvenirlik analizleri, tanımlayıcı istatistiksel yöntemler, karşılaştırma ve korelasyon analizleri kullanılmıştır.
Bulgular: Hemşirelerin öğrenme ataleti 2,61±0,52; deneyim ataleti 3,28±0,57; toplam ataleti 2,97±0,45 bulunmuştur. Öğrenme ataletinin erkeklerde, 6-10 yıl mesleki deneyimi olanlarda ve mesleki bilimsel yayın takip etmeyenlerde yüksek olduğu görülmüştür. Karşılanamayan hemşirelik bakım gereksinimleri 2,54±0,84 bulunmuştur ve en yüksek düzeyin 36 ve üstü yaş grubunda, eğitim araştırma hastanesinde, 6-10 yıl çalışanlarda ve mesleki bir örgüte üye olmayanlarda olduğu görülmüştür. Karşılanamayan hemşirelik bakım hizmetlerinin iş gücü kaynakları nedenleri 1,81±0,93; iletişim/ekip çalışması nedenleri 2,15±0,86; malzeme kaynakları nedenleri 1,99±0,99 bulunmuştur. Atalet ile karşılanamayan hemşirelik bakım gereksinimleri ve nedenleri arasında anlamlı ilişki bulunmamıştır.
Sonuç: Araştırmanın sonucunda hemşirelerde orta düzeyde atalet bulundu. Karşılanamayan hemşirelik bakımının orta düzeyin üzerinde olduğu ve bunun en önemli nedenin iletişim/ekip çalışmasına ilişkin nedenler olduğu belirlendi. Atalet ile karşılanamayan bakım arasında ilişki bulunmadı. Hemşirelerde atalet gelişmesinin önlenmesi ve karşılanamayan bakım gereksinimlerinin azaltılması konusunda önerilerde bulunuldu.
Synonymization of two, monotypic black-coral-commensal scale worm genera, Antipathipolyeunoa Pettibone, 1991 and Parahololepidella Pettibone, 1969 (Polynoidae, Aphroditiformia)
Authors: Gonzalez Brett C. , Conde-Vela Victor M. , Osborn Karen J.
Published: September 2023

Parahololepidella Pettibone, 1969 is a polynoid genus commensal with the antipatharian genus Tanacetipathes Opresko, 2001. These scale worms are elongate with numerous segments and small elytra. To date, the only other known polynoid associated with Tanacetipathes is Antipathipolyeunoa Pettibone, 1991. By re-examining the holotype of Antipathipolyeunoa, we have identified several overlooked characters that no longer distinguish this genus from Parahololepidella. Based on the presence of chaetae on the tentacular segment and elytral irregularity on posterior segments, we propose synonymizing Antipathipolyeunoa with Parahololepidella.
The Prognostic Potential of End-Stage Knee Osteoarthritis and Its Components to Predict Knee Replacement: Data From the Osteoarthritis Initiative
Authors: Driban Jeffrey B. , Lu Bing , Flechsenhar Klaus , Lo Grace H. , McAlindon Timothy E.
Published: September 2023

Objective

We aimed to determine how 2 definitions of end-stage knee osteoarthritis (esKOA) and each component (knee symptoms, persistent knee pain, radiographic severity, and presence of limited mobility or instability) related to future knee replacement (KR).

Methods

We performed knee-based analyses of Osteoarthritis Initiative data from baseline to the first 4 annual follow-up visits, and data on KR from baseline until the fifth yearly contact. We calculated a base model using common risk factors for KR in logistic regression models with generalized estimating equations. We assessed model performance with area under the receiver-operating characteristic curve (AUC) and Hosmer-Lemeshow test. We then added esKOA or each component from the visit (< 12 months) before a KR and change in the year before a KR. We calculated the net reclassification improvement (NRI) index and the integrated discrimination improvement (IDI) index.

Results

Our sample was mostly female (58%), ≥ 65 years old, White (82%), and without radiographic knee osteoarthritis (50%). At the visit before a KR, Kellgren-Lawrence (KL) grades (ordinal scale; AUC 0.88, NRI 1.12, IDI 0.11), the alternate definition of esKOA (AUC 0.84, NRI 1.16, IDI 0.12), and a model with every component of esKOA (AUC 0.91, NRI 1.30, IDI 0.17) had the best performances. During the year before a KR, change in esKOA status (alternate definition) had the best performance (AUC 0.86, NRI 1.24, IDI 0.12).

Conclusion

Radiographic severity may be a screening tool to find a knee that will likely receive a KR. However, esKOA may be an ideal outcome in clinical trials because a change in esKOA state predicts future KR.
Qu’est-ce qu’une psychanalyste d’enfants ?
Authors: Jaccard Camille
Published: September 2023

L’émergence de la profession de psychanalyste d’enfants est étudiée à partir de l’exemple de l’Office médico-pédagogique vaudois qui emploie dès sa fondation en 1942 des assistantes-psychologues pour réaliser les examens psychologiques aux moyens de tests et effectuer des suivis psychothérapeutiques. Les parcours de formation et de carrière de ces professionnel·les sont essentiellement retracés à partir des archives institutionnelles du service. La grande majorité est composée de femmes, universitaires et expérimentées. Leur formation psychologique est souvent seconde et complétée par une psychanalyse didactique. Si une minorité d’entre elles accède au fonctionnariat et que d’autres sont appelées comme auxiliaires, leur implication au sein de l’Office varie, mais toutes font preuve d’autonomie dans leur travail. Leur statut et leur rémunération sont défendus auprès des autorités par le médecin-chef qui les considère comme indispensables au bon fonctionnement de la consultation. Elles contribuent au développement de réseaux médico-psycho-pédagogiques à l’échelle nationale et internationale, même si à partir des années 1950 le débat sur l’analyse profane questionne leur statut.
On the solutions of the dual matrix equation $ A^\top XA = B $
Authors: Zeng Min , Yuan Yongxin
Published: September 2023

Let $ \mathbb{D}^{m \times n} = \{A = A_{1}+\varepsilon A_{2}|A_{1}, A_{2}\in \mathbb{R}^{m \times n}\} $ be the set of all $ m\times n $ real dual matrices. In this paper, the following problems are considered. Problem I: Given dual matrices $ A = A_{1}+\varepsilon A_{2}\in \mathbb{D}^{m\times n} $ and $ B = B_{1}+\varepsilon B_{2}\in \mathbb{D}^{n\times n} $, find $ X\in S $ such that the dual matrix equation $ A^\top XA = B $ is satisfied, where $ S = \{X\in \mathbb{D}^{m \times m}|CX = D, C, D\in \mathbb{D}^{p \times m}\} $. Problem II: Given dual matrices $ A = A_{1}+\varepsilon A_{2}\in \mathbb{D}^{m\times n}, B = B_{1}+\varepsilon B_{2}\in \mathbb{D}^{n\times n} $ and $ \tilde{X} = \tilde{X}_{1}+\varepsilon \tilde{X}_{2}\in \mathbb{D}^{m\times m} $, with $ B_{i} = B^\top_{i}, i = 1, 2 $, find $ \hat{X}\in T $ such that $ \|\hat{X}-\tilde{X}\|_{{\rm D}} = \mathop{\min}\limits_{X\in T} \|X-\tilde{X}\|_{{\rm D}} = \mathop{\min}\limits_{X\in T}\sqrt{\Vert X_{1}-\tilde{X}_{1} \Vert^{2}+\Vert X_{2}-\tilde{X}_{2}\Vert^{2}} $, where $ T = \{X = X_{1}+\varepsilon X_{2}\in \mathbb{D}^{m \times m}|A^\top XA = B \ \ \mbox{s. t.} \ X_{i} = X^\top_{i}, i = 1, 2\} $. We derive the solvability conditions and the representation of the general solution of Problem I using the Moore-Penrose inverse. Also, we deduce the solvability conditions and the explicit formula of $ T $ and the unique approximation solution $ \hat{X} $ of Problem II by applying the Moore-Penrose inverse and Kronecker product of matrices. Finally, we give a numerical example to show the correctness of our result.
Spatial Effect of Green Economic Efficiency in China From the Perspective of Informatization
Authors: Tian Xinbao , Guo Qiang , Yu Chuanhao
Published: September 2023

Green economy has been paid more and more attention in the information age. Informatization plays an important role in the development of green economy by the transmission of industrial structure rationalization and upgrading. Because of the spatial mobility of information, it is necessary to study the spatial spillover effect of information on the efficiency of green economy. In this article, the non-radial directional distance function and the comprehensive index method are used to evaluate the efficiency of green economy and informatization respectively. On this basis, the spatial characteristics of the two are analyzed. Finally, the spatial econometric model is used to analyze the spatial impact of informatization on the efficiency of green economy. The authors find that: (i)The spatial distribution of the green economy efficiency and informatization are unbalanced; (ii) There is a significant spatial spillover effect in the efficiency of green economy; and (iii) The development of informatization plays an important impact on the efficiency of green economy.
A Coin-Shaped Polypropylene Bio-Carrier Fabricated Using a Filament-Based 3D Printer for Wastewater Treatment
Authors: Widjaya Revani , Faizal Ferry , Subhan Ujang , Hidayat Sahrul , Hermawan Wawan , Joni I Made , Panatarani Camellia
Published: September 2023

The utilization of the moving bed biofilm reactor (MBBR) has been identified as a promising technology for reducing water pollutants. This study focuses on designing a novel bio-carrier using 3D printing technology for use in an MBBR for wastewater treatment. The bio-carrier is made of polypropylene filament with four variations in specific surface area. The study investigates the relationship between the specific surface area and the amount of adhering biofilm on the bio-carrier. Results show that type-4 bio-carrier with a specific surface area of 1438.16 m2/m3 and a pore diameter of 1.8 mm to 4.9 mm has the highest mass of biofilm attachment at 2.598 grams. This research provides insights for designing bio-carriers with suitable pore diameters and specific surface areas for improved MBBR performance in wastewater treatment.
Growth responses of genetically diverse rice (Oryza sativa L.) cultivars to Arsenic stress
Authors: Manawasinghe Sammani , Rohana Chandrajith
Published: September 2023

Although arsenic (As) is a toxic element for plant growth, it can accumulate in rice plants to higher levels. A case-control experiment was carried out to investigate the impact of As in soil on rice plant growth. Nine (9) different native and improved rice cultivars were grown in soils with 10 mg/kg As. Total As content in grains was quantified using an ICP-MS. The mean As content in control samples was 15.8 µg/kg while As treatment samples showed 122 µg/kg. Grains of improved rice variety of Bg 300 showed the highest As accumulation. The chlorophyll content declined by 28% under As stress and 56% tiller losses were also observed. The significant reduction of plant growth has given an impaired grain yield under As-treated conditions. Soil arsenic also showed a significant impact on Ni, Rb, and Ba uptake and accumulation. This study showed that As accumulation in rice is cultivar-dependent and also indicated a drastic reduction of the yield under elevated As levels. The native cultivar, Kahawanu was shown the lowest As-accumulation (90.1 mg/kg) under elevated As within the nine rice cultivars. So it can be identified as the best resistance cultivar for the As stress. The results can be utilized for developing high-tolerance rice varieties using new breeding technologies.