bluuebunny/crossref_metadata_2025 huggingface dataset:
A critical review of antecedents of psychological measurement: Is it necessary to revisit or reorganized the foundations Psychometry?
Authors: Martínez-Guerreroa José I.
Published: July 2021

The purpose of present essay was revisited and supplemented antecedents on psychological measurement and analyzed his foundations in a scientific perspective. This review includes since early great pioneers of measurement at the beginning of nineteen century to the principal contributions of psychometrics in the middle of twenty century. The researcher’ knowledge on the Science History in general and the analysis of theories and methodological antecedents of their discipline are very important to an integral scientific’ formation. The problems and challenges of science are showed an interdisciplinary approach that permits the comprehension of scientific concepts and methods, to improve and reorganized each discipline with a broad and new perspective. The roots of Psychometry included pioneers and contributors in Mathematical, Statistical, and Experimental Sciences, who’s had persisted with creativity in the development of theories, methods, models, technics and procedures to construct psychological measurements in social and behavioral sciences. Since the Rasch’ Model and the Item Response Theory, among others advances in multivariate statistics, the modern Psychometry have theories, models, applied strategies and methods to document validity and reliability evidence. Psychometrics today, counts with standards to guide best practices in test development and validation in behavioral sciences.
Conscientious objection
Authors: Pacheco-Gómez Alejandro
Published: July 2021

Conscientious objection is a means of exercising freedom of belief, conscience and ethical convictions in the face of legal orders that could collide with their principles by excessively invading their autonomy. Although this right corresponds to every person, the health field is one of the most frequent to invoke it, generating bioethical dilemmas at the time of its exercise.
Educational interventions for malnutrition in Mexican children
Authors: Beltrán Rodríguez María Guadalupe
Published: July 2021

INTRODUCTION: Malnutrition is the leading cause of infant morbidity and mortality worldwide. In 2019, 21% of children living in rural areas have chronic malnutrition and 24% of children under 12 years of age in the country are overweight or obese. MATERIAL AND METHOD: The objective of this article was to know the characteristics of the educational treaties for malnutrition. The search for articles and documents made in PUBMED, EBSCO, GOOGLE SCHOOLAR and government and international pages. RESULTS: 28 nutritional educational interventions were analysed. 21.4% of the studies carried out were in the state of Sonora, almost 57% of the studies were of a quasi-experimental type. The most used strategies in complications include Exhibition of theoretical and practical content; use of games (table, crossword puzzles, memoramas, etc.); physical activity and use of audiovisual media. 96% of the studies carried out had statistically affected differences with p values ​​from .05 to .000. CONCLUSIONS: The educational practices must be carried out in a holistic way determined by the following aspects: Elements of knowledge and food practices; Psycho-emotional elements; Sociocultural elements and economic elements.
Las redes sociales en la educación
Authors: Jaimes-Barrera Sandra Alejandra , Ramírez-Aguilar Paola Viridiana , Quijano-Luna Brenda Margarita , De León-Vazquez Irma Isabel , Flores-Jiménez Ivette , Tapia-Castillo Delia Iliana
Published: July 2021

El auge y la propagación de las redes sociales ha alcanzado niveles impensados. Gracias a los aportes de la Web 2.0 las redes sociales están ganando terreno frente a otras alternativas de comunicación. Una red social es una estructura social compuesta de personas, las cuales están conectadas por uno o varios tipos de relaciones, tales como amistad, parentesco, intereses comunes, intercambios económicos, o que comparten creencias o conocimiento.

Como lo menciona el autor “Levis, Diego” Las redes sociales tienen un enorme atractivo en el aspecto personal y de relación por parte del que las usa. Por este motivo, cuanto mayor sea el número de los participantes más atracción genera en los alumnos.

Retomando lo escrito por el autor “Juan José del Haro” Es indudable que la información se mueve a través de la tecnología y hay que saber sacarle provecho; en donde comenta que la educación ha cambiado de manera rápida en la actualidad, los maestros ya no son la única fuente de información a la que los alumnos pueden acudir ya que  gracias a este acceso universal, encontramos alumnos que son “expertos” en determinadas áreas del conocimiento que son de su interés y son capaces de aprender de forma autónoma.

El autor “Irene Garrigós” nos dice que las redes sociales y el uso de la tecnología en la docencia va en auge ya que estas son muy útiles creando una comunicación más estrecha entre los alumnos y el profesor.

Artero (2011) dice que en el manejo de una red social en el aula puede suponer un acercamiento entre el docente y el alumno. Los profesores dejan de ser comunicadores o transmisores de conocimiento para ser tutores que guían a los alumnos a través del proceso educativo intentando potenciar la participación de los mismos.
Negotiating the Futures of Nature and Cultures: Perspectives from Indigenous Peoples and Local Communities about the Post-2020 Global Biodiversity Framework
Authors: Cariño Joji , Ferrari Maurizio Farhan
Published: July 2021

A post-2020 Global Biodiversity Framework is currently under negotiation under the auspices of the Convention on Biological Diversity (CBD). This framework seeks to transform human-nature relationships towards its 2050 vision of “societies living in harmony with nature.” Global reports published to inform these negotiations include the second edition of Local Biodiversity Outlooks (LBO-2). In the context of ethnobiology, LBO-2 is particularly relevant because it features perspectives, experiences, and stories as told by Indigenous Peoples and local communities (IPLC) about the global biodiversity crisis. Based on these perspectives, LBO-2 identifies six areas in need of urgent transformation (i.e., in culture, land, food, economies, governance, and financial incentives), analyzing how these relate to ongoing negotiations of the post-2020 Global Biodiversity Framework. In this article, we consider these transitions, as well as recommendations made by the International Indigenous Forum on Biodiversity, and reveal critical weaknesses in the ways the Global Biodiversity Framework addresses the views and perspectives of IPLC. Such shortcomings include separation of nature and cultures in the framework's goals and targets, and failure to recognize and embed customary land tenure and territorial management as vital for biodiversity conservation, sustainable use, and benefit-sharing. We make a series of recommendations to mainstream and prioritize support for the rights and collective actions of IPLC throughout the post-2020 Global Biodiversity Framework.
Penerapan Navmesh Dengan Algoritma A Star Pathfinding Pada Game Edukasi 3d Go Green
Authors: Safira Linda , Harsadi Paulus , Harjanto Sri
Published: July 2021

Cleanliness is one of the requirements to create a healthy living environment. But in reality, not everyone have a concern for environmental hygiene and health. For this reason, learning about the importance of caring for environmental cleanliness must be instilled early on. One interesting method to provide learning about environmental cleanliness can be through games. With the 3D visualization of this environmental cleanliness game, it is an effort to raise awareness of the importance of environmental hygiene and health in the community. The location used in making this game is Campus 1 Poltekkes Surakarta. The purpose of this study is implementation of Navmesh with the A Star (A*) Pathfinding Algorithm on the characters so that players can find the trash location point and the location point of the tree with the shortest route. Making this game uses the GDLC (Game Development Life Cycle) method with stages of Initiation, Pre Production, Production, Testing, Beta and Release. This game can be played on desktop and mobile devices. The results of the research that has been done are seen from the algorithm simulation testing is the nodes that are passed by as many as 50 nodes, where there are duplicate data as many as 7 nodes due to real time systems that read nodes over and over. Thus, the application accuracy rate reaches 86%.Keywords: Educational Games, A * Pathfinding, Navmesh
Prediksi Penjualan Kertas Menggunakan Metode Double Exponential Smoothing
Authors: Putro Erinsyah Aditya Nugroho , Rimawati Elistya , Vulandari Retno Tri
Published: July 2021

One of the important thing in business is the inventory of goods and services. Business goal can be reached when business owner know how the number of their inventory. Printing business is using forecasting model in their purchasing raw materials to estimate and calculate their selling prediction. That model is used to minimize economic losses when the costumer canceled order because paper was ran out and to prevent paper damage does not occur date to storage that to long. Double Exponential Smoothing method is used in this research to predict the sales of Paper A and HVS A3+ paper and calculates the prediction error with MAPE (Mean Absolute Percentage Error). This study aims to make an accurate forecasting application. The prediction results from application are in the form of prediction calculations for sales in the following month which will be used to optimize the purchase of paper to be sold. In applying the research results of Paper A and HVS A3 +, the best alpha was obtained in the 12th period, namely 0.3 and 0.6 with a MAPE error of 12% and 18% and an accuracy rate of 88% and 82% where the alpha was used to predict period 13 and produces a forecast value of 446 for Paper A and 474 for HVS A3 +
Gli Studi Iberici: passato, presente, futuro
Authors: Pérez Isasi Santiago
Published: July 2021

This article intents to offer a panoramic view of the field of Iberian Studies, a fairly young academic field devoted to the study of Iberian literatures and cultures, which has gained some level of recognition and visibility in recent years. I will present its multiple genealogy, its different origins and theoretical foundations in diverse geographical and academic spaces; its current state, with a quantitative and qualitative analysis of its publications and of its level of institutionalization, and  some proposals for its future development, based on the most recent debates and criticisms about this discipline. I will try to show that, without any intention of becoming homogenic or hegemonic, Iberian Studies have promoted new ways of studying Iberian cultures superseding linguistic, political or academic barriers.
Legge di Taso sugli onori ai caduti in guerra e alle loro famiglie
Authors: Giannotti Andrea , Proietti Giorgia
Published: July 2021

The stele, to be displayed in the civic prytaneion, preserves a public decree concerning honours for the war dead, norms and limitations to their public mourning, as well as provisions for the fallen’s fathers and sons. The decree, dated to mid-4th century B.C. on a paleographical basis, has been recently connected with the war the Thasians fought against the Thracians to protect their colony Datos/Krenides between 360 and 356 B.C. The first section (ll. 4-14) concerns public honours for the war dead, while the second section (ll. 14-49) deals with public provisions for the war dead’s fathers and sons. Concerning both the special treatment of the war dead and the welfare in favour of the war orphans, a useful comparison can be drawn from the analogue Athenian practice in Classical times.
Proskynema of the Achaean Theodotos for Ptolemy XII
Authors: Rossini Alessandro
Published: July 2021

A proskynema by an Achaian, at Philae, for Ptolemy XII and his children, is usually dated to the king’s widowhood. The death of Cleopatra Tryphaena, Ptolemy XII’s only known official wife, has been placed in 69-68 BC, while his youngest child was born in 59 to an unknown woman. Ptolemy died in 51. The inscription was dated 59/58-52/51. But traces of the reappearance of Tryphaena during the kings’s exile (58-55) – together with Berenice, the only legitimate daughter – implies that Tryphaena was deposed and subjected to abolitio memoriae, and that Ptolemy got involved in relationships illegitimate to Greek eyes. The absence of any queen in the proskynema could derive from their unimportance from a Greek point of view, and the epigraph could be, at least, ten years older.
PERENCANAAN PEMBANGUNAN PLTS HYBRID DI PONDOK PESANTREN AL-ANWAR 4 SERANG, KABUPATEN REMBANG, PROVINSI JAWA TENGAH
Authors: Ariawan Andrian Mayka , Sinaga Nazaruddin
Published: July 2021

Dalam menyikapi fenomena tingginya emisi karbon di dunia, Pemerintah Provinsi Jawa Tengah turut berkomitmen untuk meningkatkan rasio pemanfaatan energi baru dan terbarukan (EBT) dengan target sebesar 21,32% pada tahun 2025. Sampai dengan tahun 2020 realisasi bauran EBT di Jawa Tengah baru mencapai 11,89%, sehingga masih perlu peningkatan sebesar 9,43% dalam kurun waktu 5 (lima) tahun. Dalam rangka mencapai target tersebut Pemerintah Provinsi Jawa Tengah gencar melakukan pengembangan Pembangkit Listrik Tenaga Surya (PLTS), salah satunya melalui sosilaisasi kepada masyarakat dengan membangun PLTS pada lembaga yang memiliki nilai edukatif dan berperan membentuk karakter sumber daya manusia di masa yang akan datang seperti pondok pesantren. Pembangunan PLTS membutuhkan biaya investasi cukup tinggi, sehingga dibutuhkan perencanaan yang baik dari sisi kelayakan lokasi, desain engineering, perhitungan total kapasitas pembangkitan, dan jenis PLTS yang dibutuhkan agar dapat bermanfaat dengan optimal. Mendasari hal tersebut, tulisan ini akan membahas contoh perencanaan pembangunan PLTS di Pondok Pesantren Al-Anwar 4 Serang, Kabupaten Rembang, Provinsi Jawa Tengah. Rekomendasi desain PLTS yang dibangun pada area seluas 80 m2 adalah sistem PLTS hybrid yang dipasang membentuk kanopi dengan modul surya berkapasitas 340 Wp sebanyak 30 buah dengan total kapasitas 10,2 kWp dilengkapi dengan sistem backup baterai, rumah daya, dan penangkal petir. Berdasarkan hasil simulasi menggunakan software PV*SOL, PLTS tersebut dapat menghasilkan energi listrik hingga 38,49 kWh per hari atau setara dengan 14.052 kWh per tahun dengan performance ratio sebesar 81,9% sehingga dapat melakukan penghematan biaya listrik hingga Rp. 12.646.800,- per tahun atau setara dengan Rp. 1.053.900,- per bulan.Kata Kunci : PLTS, Hybrid, Modul Surya, Desain, Pondok Pesantren Al-Anwar 4
Results of Treatment of Patients with Ureterolithiasis by Extracorporal Shock Wave Lithotripsy on Siemens Modularis Uro
Authors: Vozianov Oleksandr
Published: July 2021

Extracorporeal shock wave lithotripsy (ESWL) has been used in the treatment of urolithiasis since 1980s. The method has proven to be effective and minimally invasive, but in last years the effectiveness of the method has decreased significantly from 90 % to 60 %. Studying of the causes of this phenomenon and methods of improving treatment outcomes are important problems of modern minimally invasive urology.

The objective: to evaluate the effectiveness of the application of ESWL on Siemens Modularis Uro in the treatment of patients with ureterolithiasis.

Materials and methods. ESWL was performed in 662 patients with ureteral stones ranging in size from 5 mm to 19 mm on Siemens Modularis Uro.

Results. In 95.01 % of cases, the urinary tract was free of stones by the method of ESWL, the removal of stones in 1 session occurred in 376 (56.8 %) patients, with repeated – in 253 (43.2 %) patients. In 33 (4.99 %) patients the result of ESWL was unsatisfactory, fragmentation or elimination of stone fragments did not occur and for these patients ureteroscopy (ureterolithotripsy) was performed as second stage of treatment. During endoscopic intervention in 78.8 % of patients the fragmentation was satisfactory (fragments were smaller than 4 mm), but the elimination of fragments did not occur due to changes of the wall of the ureter in the area of its primary location. The overall rate of stone fragmentation after ESWL sessions in the patients in the trial was 98.94 %. Conducting ESWL with the proposed parameters did not affect the effectiveness of the method (p>0.1), but allowed to significantly increase the life of medical equipment. No complications directly related to lithotripsy were detected.

Conclusion. The obtained results make possible to consider ESWL as a priority method of treatment for patients with ureteral stones up to 15 mm, taking into account the risk factors of inefficiency.
Influence of Radioactive Background on an Idiopathic Form of Infertility Incidence in Men from Different Regions of Ukraine
Authors: Gorpynchenko Ihor , Gurzhenko Yurii , Spyrydonenko Volodymyr , Lytvynets Yevhen
Published: July 2021

There are 143 men (group I) with idiopathic infertility in the form of asthenozoospermia of the II degree living in the territories of the Kiev region (Poles’ky, Chernobylsky, Ivan’kovsky, Borodyansky, Vyshgorodsky districts) were investigated in the Department of Sexual Pathology and Andrology of the SI «Institute of Urology of the National Academy of Medical Sciences of Ukraine» and exposed to ionizing radiation due to the Chernobyl accident in 1986. All individuals in the I group were born from parents who were in the accident at the Chernobyl nuclear power station in the area of radioactive contamination and permanently resided in areas with a high level of radioactivity. The control group was made up of persons born and living in the Ivano-Frankivsk region with a similar condition (group II, n=57). The mean age of the studied group I was 28,3±2,4 years, and persons of the II group were 30,1±2,8 years. Diagnosis of II was performed ambulatory in accordance with WHO and Ministry of Health of Ukraine standards. The study was to study and compare spermogram parameters in patients from both groups.

It has been established that the reproductive problems of men with idiopathic infertility living in radiation-polluted areas of the Kiev region of Ukraine consist in a significant violation of the quality indicators of ejaculate (mobility by the pool A+B is less than 1,6 times, p<0,05) correlating with modifications of physicochemicals (the average time of liquefaction is 1,4 times greater, p<0,05) and biochemical (decrease of levels of fructose by 2,2 times, citrate – by 1,6 times, p<0,01–0,05) data characterizing the effect of ionizing radiation, as one one of the leading factors of male genital function violation. The study found that the level of general indicators of spermogramm is significantly worse in the regions of Ukraine who were exposed to radioactive contamination due to the Chernobyl accident, in contrast to the indicators of persons from conditionally pure regions.
Efficacy of an Herbal Preparation Based on Lovage, Rosemary, and Centaury on Patients After Extracorporal Shockwave Lithotripsy
Authors: Vitkovskyy Volodymyr
Published: July 2021

Study objective: to study the effect of a herbal preparation containing a standardised BNO 1040 extract* (based on lovage root, rosemary leaves and aerial parts of centaury) on the extracorporeal shockwave lithotripsy (ESWL) results in patients with urolithiasis (UL).

Methodology. 150 patients with UL (aged 18–65 years) treated with ESWL method were divided into 2 equal groups. The main group (n = 75) received standard recommendations and herbal preparation (12 months). The control group (n = 75) received standard recommendations only. The following was evaluated: time and degree of elimination of fragments; the presence of pain and leukocyturia; recurrent stone formation.

Results. The elimination of fragments was observed up to 14 days in 94.7 % of patients in the main group versus 76 % of patients in the control group. Renal colic was observed in 6.7 % of patients in the main group versus 10.7 % of patients in the control group; cases of leukocyturia were observed within 14 days in 10.7 % versus 22.7 %, respectively. During the year, a recurrent lithiasis was diagnosed in 6.7% of patients in the main group and in 16 % of patients in the control group.

Conclusion. The use of BNO 1040 extract in combination with ESWL: contributes to more rapid and safe elimination of fragments of the calculi and reduces the risk of recurrent stone formation.
Place of Duloxetine in Concervative Treatment Women and Men with Stress Urinary Incontinence
Authors: Gorovyi Viktor , Litvinets Vladyslava , Gurzhenko Olena
Published: July 2021

History of introduction of duloxetine in medical practice, mechanism of action and using of duloxetine in concervative treatment women and men with stress urinary incontinence are shown. Modern structure of external urethral sphincter in women and men was shown with increasing of sphincter tone under duloxetine influence.

Duloxetine recommended by International Continent Society for initial treatment women with stress urinary incontinence but this drug gives only improvement of urine continence and quality of life with side effects. Duloxetine with connection with pelvic floor muscle training gives better results than using separately duloxetine and pelvic floor muscle training. Nausuea is the most frequency side symptom after using duloxetine. Results of own investigations were shown and indications for using duloxetine in women with stress urinary incontinence were summed up. The most positive results were obtained after combination of duloxetine with pelvic floor muscle training and electrostimulation of urethral sphincter. Duloxetine for treatment men with stress urinary incontinence after radical prostatectomy is only clinical tested. Estimation of efficacy of duloxetine in treatment men with stress urinary incontinence after open prostatectomy due to benign prostatic hyperplasia is needed.
Dutasteride 5α-reductase Inhibitor in the Treatment of Benign Prostatic Hyperplasia: Systematic Review and Meta-analysis
Authors: Romaniuk Maksym , Aksonov Pavlo
Published: July 2021

Dutasteride is a competitive inhibitor of the enzyme 5-alpha-reductase and is commonly used to treat the symptoms of benign prostatic hyperplasia (BPH).

Objective: to determine the efficacy and safety of dutasteride in terms of indicators that are important in clinical practice.

Data sources. The literature was searched using the search terms «prostate hyperplasia», «prostate hypertrophy», «dutasteride», «quality of life», and «adverse drug reaction». Articles were obtained from Embase, PubMed, the Kokhranov Central Register of Controlled Trials, with a search till December 2020.

Study selection and data recovery. Randomized controlled trials, quasi-randomized trials, and systematic reviews evaluating the efficacy of dutasteride, both in monotherapy and in combination with alpha-blockers for the treatment of men with BPH were included in the analysis. Indicators were the need for prostate surgery, episodes of acute urinary retention, discontinuation of therapy due to side effects, the number of patients who had serious side effects, mortality and sexual dysfunction.

Data analysis. Four studies involving 1,879 patients were evaluated. All studies have shown significant clinical efficacy of dutasteride to the need for prostate surgery, with episodes of acute urinary retention that was higher than finasteride with equal safety profiles.

Conclusion. No statistically significant differences between the two 5AR inhibitors finasteride and dutasteride in terms of safety profile were found, based on the studies included in this system review. This determines the best clinical efficacy of dutasteride in terms of the number of cases of acute urinary retention and the need for surgery.
Dexibuprofen in the Practice of a Family Doctor
Authors: Shurpyak Serhii , Holota Liubov , Solomko Oleh
Published: July 2021

Pain is an unpleasant sensory and emotional sensation associated with tissue damage or described in terms of such damage. Pain of different localization is one of the most common symptoms in modern clinical practice and one of the most common reasons for seeking medical care at the outpatient stage.
One of the most promising and effective pathogenetic means of protection of peripheral pain receptors (nociceptors) are nonsteroidal anti-inflammatory drugs (NSAIDs). Every day, more than 30 million people in the world take NSAIDs, more than 300 million a year, and only a third of them take nonsteroidal anti-inflammatory drugs as prescribed by a doctor. However, patients taking various drugs today are considered as possible etiological and provoking factors in the development of a number of diseases of various organs and systems. All this determines the importance of selecting the optimal drug from the group of nonsteroidal anti-inflammatory drugs both from the standpoint of effectiveness and from the standpoint of safety in real clinical practice and including at the outpatient stage of providing medical care to the patient.
One of the latest developments in this direction is dexibuprofen, the right-handed active isomer of ibuprofen, which according to numerous studies can be used as a symptomatic therapy of pain of mild to moderate intensity of various origins: toothache, back pain, joints, muscles, rheumatic pain, dysmenorrhea, and feel free to recommend it to a wide range of patients, as it has the optimal combination of efficacy and safety profile.
The Outcomes of an Improved Treatment of Patients with Type 2 Diabetes and Non-alcoholic Fatty Liver Disease
Authors: Mykhalchyshyn Halyna
Published: July 2021

Nowadays we notice the increase of cases that combine type two diabetes mellitus, and nonalcoholic fatty liver disease. As a result, the course of disease aggravates. The pathogenesis, diagnoses and treatment of NAFLD remain unclear.

The objective: of our study is to determine the clinical efficacy of an improved therapeutic measures set in patients with type 2 diabetes and NAFLD.

Materials and methods. We’ve examined 132 patients with type 2 diabetes mellitus and NAFLD. All patients gave their consent to participate in the study. They also received all necessary nutrition and workout recommendations. We split the patients into two groups. First group patients (n=37) received antihyperglycemic drugs (metformin, gliclazide or glimepiride). Patients of the second group (n=95) additionally received DPP-4 inhibitors (saxagliptin or sitagliptin), atorvastatin, and the multiprobiotic. Patients of the second group were divided into 2 subgroups: 2A group with standard level of transaminases, and 2B group with an increased level of transaminases accordingly.

Results. Improved set of therapeutic measures revealed distinctively positive effect on the dynamics of clinical manifestation of lesions of the hepatobiliary system in patients with diabetes. There were no such changes in another group. Under the influence of complex treatment in the second group of patients, the functional state of liver improved due to a significant decrease of ALT, AST, TG and VLDL levels in the blood serum. Size of the liver decreased, liver stiffness indicators improved according to shear wave elastography data.

Conclusions. Combined therapy, which includes DPP-4 inhibitors, statins and multiperiodic is effective in the treatment of patients with type two diabetes and nonalcoholic fatty liver disease.
Efficacy and Safety for Use Desloratadine in Children with Allergic Conditions (Literature Review, Own Research)
Authors: Marushko Yurii , Khomych Olha
Published: July 2021

According to scientists, more than 20 thousand allergens are known and their number is constantly increasing. Therefore, children’s allergy remains one of the urgent problems of modern medicine, since allergic diseases in adults in most cases begin from childhood.

The article summarizes our own data and presents a scientific review of the medical literature, which is devoted to the analysis of the problem of treatment of allergic diseases with desloratadine in children. Nowdays there is a significant prevalence of allergic conditions in children. We analyzed the effect of desloratadine on the course of allergic diseases in children. The analyzed literature review showed a high safety profile of the drug desloratadine. Also we presented the personal data of desloratadine therapy for seasonal allergic rhinitis in children.

The literature data presented in the article and our own experience allow us to conclude that allergic conditions remain an urgent problem in clinical medicine, and the use of antihistamines, in particular desloratadine, increases the effectiveness of allergy therapy and accelerates the recovery and disappearance of symptoms.
Effective, safe and rational pharmacotherapy of endogenic progesterone deficiency
Authors: Opryshko V.I.  , Мamchur V.I.  , Nosivets D.S.  , Prokhach A.V.  , Kurt-Ametova A.S. 
Published: July 2021

Today, the most frequent complication of pharmacotherapy is an allergic reaction, the so-called drug or drug allergy. An allergic reaction can be caused both by the active ingredients and by the excipients included in the composition of the drug to provide a certain dosage form and its physicochemical properties. Vaginal progesterone preparations are characterized by a large variety of dosage forms: gels, tablets and gelatin capsules for intravaginal administration. It is known that the safety and efficacy of pharmacotherapy depend on the active substance, the dosage form, and the base of the intravaginal preparation, as well as the indices of adherence to medication therapy. At the same time, the base - excipients can cause the development of adverse reactions.The authors of the article, based on an analytical review of domestic and foreign literature, analyzed effective, safe and rational pharmacotherapy of endogenous progesterone deficiency.It is shown that micronization is currently used to improve the bioavailability of natural progesterone – a method of increasing solubility by reducing the particle size of the drug substance. Due to the high solubility of the substance, the risk of possible side effects is reduced, which allows increasing the safety of the drug.The peculiarity of the dosage form for vaginal administration is described. On the basis of the analysis of various forms of progesterone, the clinical efficacy of natural progesterone for vaginal administration has been substantiated.The authors found that the use of progesterone in sublingual and vaginal forms is the most rational in terms of convenience, efficacy and safety.
Morphological and electron-microscopic features of the investigated placente in very early previous delivery, complicated premature rupture of membranes
Authors: Malanchuk O.B.  , Poladich I.V.  , Kostenko O.Yu.  , Avramenko S.O.
Published: July 2021

The article presents modern phenomena about morphological and electron microscopic features of the studied placentas in very early premature birth, complicated by premature rupture of membranes. These features were studied in different tactics of data management of pregnant women. The objective: study of morphological and electron microscopic features of the studied placentas in very early preterm birth, complicated by PRPO.Materials and methods. All 206 patients were divided into two groups. The main group included 150 pregnant women with PRPO at a gestational age of 22–28 weeks, and the control group included 56 pregnant women with a physiological course of gestation at a period of 22–28 weeks. The main group is divided into 2 groups depending on the duration of waiting tactics and the method of delivery. Group I patients received treatment in accordance with clinical protocols by orders of the Ministry of Health of Ukraine. Pregnant women of group II were offered a tactic that involves prolonging gestation for 5 days (antibiotic therapy, RDS prophylaxis, magnesium therapy, in the presence of streptococcus B – treatment) followed by delivery by cesarean section. All patients with PRPO received antibacterial therapy from the day of hospitalization. Results. The results of the study indicate that no significant differences between the study groups during the study were found. The expression data of progesterone receptors correspond to the results of hormonal research, which also did not reveal significant changes in the study groups, and confirm the theory of finding new provoking factors of PRPO in preterm birth. Conclusions. Thus, it was first demonstrated that the content of progesterone in blood plasma and immunohistochemical expression of progesterone receptors in the placenta on the background of DRPP depends on the gestational age and not on the duration of the anhydrous period.
Determining diagnostic markers of intrautering growth retardation in early pregnancy
Authors: Vdovichenko Yu.P.  , Golyanovskyi V.O. 
Published: July 2021

Intrauterine growth restriction is the cause of significant increases in perinatal mortality, morbidity and problems in the development of newborns and infants. The leading place of this pathology is not accidental, because according to various authors, the frequency of perinatal loss associated with it is from 19 to 287‰ and more, the level of perinatal morbidity - from 58.7 to 88.0%.The objective: To determine certain serum and ultrasound markers during the first trimester of pregnancy and to improve the perinatal morbidity and mortality rate in women with intrauterine growth restriction. Materials and methods. A prospective study of pregnant women in the gestation period of 11 weeks 0 days – 13 weeks 6 days, which was to determine the level of plasma protein A associated with pregnancy (PAPP-A), mean platelet volume (MPV), and ultrasound placenta examination. Pregnant women were divided into 2 groups: the main group (n1-52) and the control group (n2-50). The study group consisted of women with a low PAPP-A level and changes in the mean platelet volume towards their increase. It is this group of women that is more sensitive, in our opinion, for the development of placental disorders and the occurrence of fetal growth retardation.Results. In this study, PAPP-А levels in 39 pregnant women were <0.5 MoM, and WTO levels in 36 cases were> 10 fl, which, according to the literature, can be used as markers of early prediction of ZRP.Ultrasound type of disorders of the first stage of trophoblast invasion is described as intra- and / or periplacental pathological areas, which can be considered the causes of placental insufficiency, which results in a risk of ZRP. According to the study, high specificity and sensitivity of Doppler parameters with the determination of indices (PI and IR) in the uterine arteries were established. Conclusions. The results of the study showed that performing a screening based on a detailed history and determining PAPP-A, MPV, and ultrasound examination at first trimester of pregnancy in women with the risk of IUGR allows for prophylactic treatment and monitoring of pregnancy and thus reduces neonatal morbidity and mortality.
Vaginal delivery after previous caesarian section
Authors: Zahorodnia O.S.  , Leush S.S.  , Ventskivs’ka I.B. 
Published: July 2021

The article is devoted to the issue of vaginal delivery after a previous cesarean section, considers the state of the problem in the world, provides considerations for some features of labor in these cases and their impact on the decision of the doctor. The objective: is to investigate the features of vaginal delivery after a previous cesarean section. Materials and methods. The features of labor of 46 patients with previous cesarean section (group I), 30 nulliparous (group II) and 30 multiparous (group III) was analyzed. The duration of the first period of labor, the duration of the latent phase, the duration of the second period of labor, as well as the frequency of major obstetric complications were studied. Results. It is demonstrated, that the average duration of the first period of labor and the latent phase of this period after the previous cesarean section are close to the first labor. In contrast, in women who give birth vaginally after a previous cesarean section, the processes of shortening and smoothing of the cervix occur in parallel, as is typical for second labor. Also, these women are more prone to slowing down the strength and intensity of contractions, the dynamics of the opening of the cervix than nulliparous and multiparous without history of cesarean section. No differences in the time of rupture of membranes, the duration of the second period of labor and the frequency of other obstetric complications was not detected. Conclusions. 1. The vaginal delivery after previous cesarean section has certain physiological features that should be considered when assessing the effectiveness of labor, namely – the duration of the first period of childbirth is corresponding to the first labor, and the sequence of changes in the cervix (smoothing, opening) – to recurrent labor. Such births are more often characterized by a slowdown in the rate of opening of the cervix. 2. The frequency of major obstetric complications (meconium impurities in amniotic fluid, placental abruption, hypotonic haemorrhage) by vaginal delivery after a previous cesarean section is not greater than in other vaginal deliveries.
Polycystic ovary syndrome: clinical and pathogenetic aspects of a multidisciplinary problem
Authors: Syusyuka V.G. , Sergienko M.Y. , Makurina G.I. , Yershova O.A. , Chornenka A.S.
Published: July 2021

The article presents data from guidelines, consensus and literature sources on the modern point of view regarding to the pathogenesis, diagnosis and principles of treatment of women with polycystic ovary syndrome. It is a systemic pathology that occurs in women of any age, from puberty to menopause, involving almost all systems of the body in the process. The work focuses on the variability of the clinical manifestations of this syndrome, which is characterized by menstrual irregularities, infertility, polycystic changes in the ovaries according to ultrasound, dermatopathies and metabolic disorders. The main purpose of diagnosing the syndrome is to determine the severity of clinical manifestations, the sources and pathogenesis of androgen hyperproduction, the impact on reproductive function, as well as the assessment of metabolic and cardiovascular risks. Given the multifaceted clinical manifestations, the management of women with polycystic ovary syndrome requires a multidisciplinary approach, and pathogenetic therapy should include normalization of the hormonal profile and menstrual function, treatment of dermatopathies, correction of metabolic disorders, treatment of infertility (if pregnancy is relevant), etc.
Modern approaches to the treatment of mastopathy and correction of hyperestrogenic conditions in women of fertile age
Authors: Podolskyi Vl.V. , Podolskyi V.V.
Published: July 2021

Among the diseases that can lead to miscarriage and premature termination of a planned pregnancy, hyperestrogenic conditions play an important role. The state of impaired synthesis of estradiol metabolites significantly affects the development of mastopathy, endometrial hyperplasia, impaired implantation of fertilized eggs, metabolic disorders in women and is a risk factor for cancer of the reproductive system.To date, the urgency of the problem of hormonal diseases of the female reproductive system, including the mammary glands, is beyond doubt. In this case, dyshormonal diseases of the breast are a reflection of hormonal disorders of the entire female body and serve as a basis for the development of breast cancer. The main method of treatment for dyshormonal processes is hormone replacement therapy, but currently there is an alternative to hormonal drugs, which include non-hormonal phytotherapeutic complexes based on the biologically active substances indole-3-carbinol, barberry extract and polyphenols that normalize estrogen antiproliferative activity, have an antioxidant effect, implement antitumor action.
Comparative efficacy оf non-surgical correction of early-onset genital prolapse based on differentiated approach
Authors: Kaminskyi V.V. , Chaika K.V. , Lavreniuk Yu.V. , Diadyk O.O. , Beketova Yu.I. , Baryshnikova O.P.
Published: July 2021

The paper presents the results of the comparative efficacy of non-surgical correction of early-onset genital prolapse (GP) in women of perimenopausal and menopausal age using differentiated approach. The objective: to study morphological traits of the vaginal walls and to compare the effectiveness of non-surgical techniques of GP correction. Materials and methods. The study involved 120 patients with early-onset GP. The treatment group (Group 1) consisted of 90 women with GP who were divided into three subgroups depending on the non-surgical correction technique chosen (utility model patent No.145380 from 10.12.2020): 1a (n=30) – GP correction by platelet-rich autoplasma, 1b (n=30) – GP correction by hyaluronic acid-based agent, 1c (n=30) GP correction using СО2 laser radiation. The experimental group (Group 2) consisted of 30 patients who underwent GP correction by training the pelvic floor muscles individually according to the standard method.Results. Three months after the treatment according to the patented method, the number of patients with GP of grade 2 decreased by 16.7% in group 1a, by 31.3% in group 1b and by 41.2% in group 1c. In patients of 1c subgroup, where the presence of the combined type (cystorectocele) of GP prevailed, in 19 women (63.3%) after the treatment there was an improvement in the morphological structure of the vaginal wall, which was manifested by a pronounced diffuse improvement in angiogenesis (in all layers) due to neoangiogenesis, preserved structure of collagen fibers with increasing density of the latter in the absence of signs of edema and mild degenerative changes. It should be noted that in subgroup 1b, three months after the treatment 17 (56.6%) women had no complaints which was associated with a significant improvement in the indicator of the size of elastin and collagen fibers, and only in 9 patients (30%) this indicator remained without changes. In subgroup 1a, the evaluation of the effectiveness of the non-surgical technique showed that only 10 (33.3%) women had a slight improvement in quality of life compared to baseline before treatment. In the experimental group, there was no positive dynamics, and in 9 women (30%) three months after the treatment there was an increase in manifestations of GP and symptoms associated with it, which was confirmed by such morphological changes as minimal focal signs of neoangiogenesis, thinned, significantly swollen collagen fibers, surrounded by interlayers of connective tissue.Conclusions. This algorithmic approach in non-surgical correction of GP contributes not only to the effective treatment of early-onset GP, prevention of further progression, but also to a significant improvement in quality of life.
Peculiarities of pregnansy and childbirth in patients with a burdened gynecological anamnesis
Authors: Andriichuk T. P. , Senchuk A. Ya. , Chermak V. I.
Published: July 2021

The objective: to study the features of pregnancy, childbirth, postpartum period, fetal status and newborns in patients with a history of chronic salpingo-оophoritis.Materials and methods. Conducted a retrospective study of 150 birth histories and neonatal development maps. All patients were divided into two groups. The main group includes 100 patients with chronic salpingo-оophoritis, for which they received anti-inflammatory treatment from 1 to 3 times before pregnancy. The control group included 50 pregnant women who did not suffer from chronic salpingo-оophoritis.Results. Our analysis of pregnancy, childbirth, fetal and neonatal status in women with chronic salpingo-оophoritis indicates that such patients have a complicated obstetric and gynecological and somatic history, which forms an unfavorable basic condition of organs and systems, imperfect adaptation to pregnancy, high risk of failure of adaptive reactions. The result is a violation of the formation and development of the mother-placenta-fetus system and, as a consequence, a high level of complications during pregnancy, childbirth and perinatal pathology.Conclusion. Patients suffering from chronic salpingo-oophoritis should be considered at high risk of possible complications during pregnancy and childbirth. This category of women needs quality preconception training and careful monitoring during pregnancy.
Ceyhan Havzasındaki Suların Bazı Özelliklerinin Faktör Analizi ile İncelenmesi
Authors: DEMİRKIRAN Ali Rıza , ÇELİK Şenol
Published: July 2021

Bu çalışmada, Ceyhan nehri havzasındaki suların bazı fiziksel ve kimyasal özellikleri Faktör Analizi ile incelenmiştir. Havzadaki çeşitli baraj, göl ve derelerden (36 konumdan) alınan su örneklerinde bulunan; Ca, Cl, Renk, Elektriksel iletkenlik (EC), F, M-Al, Mg, Mn, Na, NH4-N, NO2-N, NO3-N, o-PO4, p-Al, pH, Sıcaklık (T), Toplam Çözünmüş Madde (TDS) ve Toplam sertlik (TH) olmak üzere 18 değer ölçülmüştür. Faktör analizi uygulamasında KMO (Kaiser-Meyer-Olkin Ölçüsü 0.60 olarak hesaplanmış ve Bartlet Küresellik test istatistiği 883.50 ve p
Bor ve Çinko İçerikli Yaprak Gübresi Uygulamalarının Kiraz (Prunus avium L.) Meyvelerinin Bazı Kalite Özellikleri Üzerine Etkileri
Authors: İKİNCİ Ali , ALDANMAZ Şükran , BOLAT İbrahim
Published: July 2021

Bu araştırma, Prunus mahaleb L. anacı üzerine aşılı 0900 Ziraat kiraz çeşidinde, bor ve çinko içerikli yaprak gübrelerinin bazı meyve kalite özellikleri üzerine etkilerini belirlemek amacıyla 2018 yılında Yeşilli (Mardin) ilçesindeki iki ayrı kiraz bahçesinde yürütülmüştür. Çalışmada; kontrol, 100 L suya 150 cc Maxifruit (1. uygulama), 150 cc Fertileader® Oris (2. uygulama) ve 100 cc Fertileader® Oris + 50 cc Fertileader® Alpha (3. uygulama) yaprak gübreleri kullanılarak, tam çiçeklenmeden 15-30 gün ve tam çiçeklenmeden 30-45 gün arasında iki defa uygulama yapılmıştır. Araştırma kapsamında kullanılan yaprak gübrelerinin meyve çapı, meyve boyu, meyve eni, meyve sap uzunluğu, meyve eti sertliği ve SÇKM miktarı üzerine etkisinin önemli olduğu belirlenmiştir. 0900 Ziraat kiraz çeşidinde, bor ve çinko içerikli yaprak gübresi uygulamalarında en ağır meyveler 8.41 g ile 2. uygulamadan, en büyük meyve çapı 27.32 mm ile 2. uygulamadan, en uzun meyve sapı 50.52 mm ile 1. uygulamadan, meyve eti en sert olan meyveler 297.78 g ile 2. uygulamadan, en yüksek L* renk değeri 28.40 ile 2. uygulamadan, en yüksek a* renk değeri 14.35 ile 2. uygulamadan, en yüksek b* renk değeri 356.20 ile 2. uygulamadan, en düşük meyve suyu asitliği %0.60 ile 1. uygulamadan ve en yüksek SÇKM oranı %17.23 ile 2. uygulamadan elde edilmiştir.
Üreticilerin Sulama Öncesi Bilgilerinin Tarımsal Yayım Açısından Değerlendirilmesi: Suruç Ovası Örneği
Authors: ÖCAL KARA Fatma , BİNİCİ Turan
Published: July 2021

Bu çalışmada, sulamaya açılacak Suruç Ovası’nda, durum değerlendirmesi yaparak tarımsal, çevresel, sosyo-kültürel yapıya ilişkin sorunları ortaya koymak, tarımsal yayım açısından çıkarımlarda bulunarak çözüm önerileri gerçekleştirmek amaçlanmıştır. Şanlıurfa İli’ne bağlı Suruç İlçesi’nden 96 üretici araştırma kapsamına alınmış, 24 köyde yüz yüze anket yapılmıştır. Ayrıca, nitel araştırmalarda sıklıkla kullanılan görüşme tekniği çalışmada kullanılmıştır. Çiftçilerin ana bilgi kaynakları arasında, birinci sırada ilaç satıcıları, ikinci sırada kamu yayımı, üçüncü sırada çevresi, dördüncü sırada danışmanlık şirketleri yer almaktadır. Ovada sulamanın başlamasıyla her alanda bir değişim gerçekleşebilecektir. Bu değişimlerin tarımsal, ekonomik, toplumsal, kültürel, çevresel alanlarda olması beklenebilir. En çok ekonomik yaşamda beklenen değişim, sosyo-kültürel alanda da büyük bir değişime neden olabilir. Kısaca sulama, ovada yeni bir toplumsal değişim süreci başlatacağından, sulama sonrası yapılacak durum değerlendirmelerinde disiplinlerarası çalışma gereği ortaya çıkmaktadır. Ayrıca araştırmada, eşgüdüm ve tarımsal yayım için öneriler geliştirilmiştir.