bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Kepuasan Pasien Terhadap Pelayanan Kesehatan di RSUD Lahat Tahun 2021
Authors: Hariani Beti , Wahyudi Arie , Rawalilah Hamyatri
Published: January 2023

Satisfaction is the response or level of feeling of the patient obtained after the patient receives a health service product by comparing the perceived performance or result with the patient's needs and  expectations. This study aims to analyze patient satisfaction with health services at Lahat Hospital in 2021. This study was a quantitative study with a cross sectional approach. The sampling technique used stratified random sampling obtained a sample of 97 respondents. Data was collected using a questionnaire, then the data was analyzed using the chi square test with a significance level of p value <0.05. The  data  were  also analyzed using logistic regression test to determine the dominant variables that affect patient satisfaction. The results of the Community Satisfaction Index (IKM) in the Outpatient Lahat Hospital in 2021 were 77.44 with a service quality of "B" and service performance "Good. The results of bivariate analysis showed  that  there was a relationship between service requirements and patient satisfaction (p=0.005),  service  procedures  (p=0.000), service completion time (p=0.001). service fee (p=0.005), specification of service type (p=0.006), competence of service implementer (p=0.011), behavior of service provider (p=0.000), handling of complaints, suggestions and inputs, facilities and infrastructure (p=0.000). The results of multivariate analysis with logistic regression test showed that the most dominant variable was facilities and infrastructure (p=0.041) p value <0.05 with the largest OR value of 383.398. It is recommended to hospitals to further improve facilities and infrastructure so that patient satisfaction can increase
A Review of the Therapeutic Effects of Viola Odorata Plant in Traditional Iranian Medicine and Modern Medicine
Authors:   Department of Persian Medicine, Faculty of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Motavasselian Maliheh , Salari Roshanak ,   Department of Pharmaceutical Sciences in Persian Medicine, Faculty of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Feyzabadi Zohre ,   Department of Persian Medicine, Faculty of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Joharchi Mohammad Reza ,   Herbarium of Ferdowsi University of Mashhad, Mashhad, Iran., Ghazanfari Seyed Majid ,   Department of Persian Medicine, Faculty of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Published: January 2023

Objective: Viola odorata has been used since ancient times. According to Traditional Iranian Medicine (TIM) sources, it has a cool and moist temperament and is used for treatment of different diseases. Due to the low side effects and numerous beneficial effects of this plant, this study aims to review its therapeutic effects from the perspective of TIM and modern medicine. Methods: In this review study, a search was conducted for the materials in many TIM books such as Canon of Medicine, Tuhfat al-Momenin, al-Jami’ li-Mufradat al-Adwiya wa’l-Aghdhiya, Al-shamel fi al-Sanaat Al-Tabiat, Makhzan al-Adawiyah, Firdaws al-Hikmah fi al-Tibb, Al-Hawi fi al-Tibb, Khulasat al-Hikmah, as well as the book “PDR for Herbal Medicines”, and for the related studies in online databases such as PubMed and Scopus using the keywords sweet violet, common viola, garden violet, herbal medicine, traditional Iranian medicine. Results: The medicinal forms of Viola odorata in TIM are various and are used for skin, digestive, respiratory, and urinary system diseases. Numerous studies have confirmed the various therapeutic effects of the plant. According to studies in modern medicine, its constituents include volatile oils, glycosides, tannins, flavonoids, saponins, alkaloids, mucilage, gallates, phenols, vitamin C, coumarin, and Sitosterol. Conclusion: Studies in modern medicine have proven the traditional uses of Viola odorata. However, due to the strong potential of this plant for making various medicinal products from it, more research is needed.
Effect of a Self-care Training Program Based on Temperament Modification on the Quality of Life of Patients with Type 2 Diabetes
Authors:   Department of Children's Nursing ,Faculty of Nursing, Arak University of Medical Sciences, Arak, Iran., Varvani Farahani Pouran , Khosravi Sharareh ,   Department of Children's Nursing ,Faculty of Nursing, Arak University of Medical Sciences, Arak, Iran., Sajadi Shadi ,   Department of Children's Nursing ,Faculty of Nursing, Arak University of Medical Sciences, Arak, Iran., Latifi Seied Amirhossein ,   Department of Medicine, Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran., Javaheri Javad ,   Department of Medicine, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
Published: January 2023

Objective: Considering the high prevalence of diabetes mellitus and its effect on the quality of life (QoL) of patients which can lead to low self-care and increased risk of disease complications, this study aims to assess the effect of a self-care training program based on temperament modification on the QoL of patients with type 2 diabetes (T2D). Methods: In this quasi-experimental study, 110 patients with T2D were selected by a convenience sampling method and were randomly divided into two groups of intervention and control using the random number table. After obtaining informed consent from them, they completed a demographic from and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire, and their temperament was diagnosed by a doctor expert in Iranian traditional medicine. The intervention group received four sessions of self-care training based on temperament modification each for 45 minutes. The control group received routine treatment without any intervention. Then, they completed the WHOQOL-BREF questionnaire again three months after the intervention. Data were analyzed in SPSS software, version 22 using chi-square test, paired t-test, and independent t-test. The significant level was set at 0.05. Results: Before the intervention, there was no significant difference in the quality of life score between the intervention (83.2±11.9) and control (85±9.4) groups (P= 0.194). After the intervention, the difference was significant between the intervention (87.7±11.3) and control (85.1±9.5) groups (P=0.044). There was no significant difference in the quality of life score in control group before and after the intervention (P=0.244). Conclusion: The self-care program training based on temperament modification can improve the quality of life of patients with T2D.
Rhodobacter capsulatus PG Lipopolysaccharide Blocks the Effects of a Lipoteichoic Acid, a Toll-Like Receptor 2 Agonist
Authors: Zubova Svetlana V. , Kosyakova Nelli I. , Grachev Sergey V. , Prokhorenko Isabella R.
Published: January 2023

Lipopolysaccharides (LPS) and lipoteichoic acids (LTA) are the major inducers of the inflammatory response of blood cells caused by Gram-negative and some Gram-positive bacteria. CD14 is a common receptor for LPS and LTA that transfers the ligands to TLR4 and TLR2, respectively. In this work, we have demonstrated that the non-toxic LPS from Rhodobacter capsulatus PG blocks the synthesis of pro-inflammatory cytokines during the activation of blood cells by Streptococcus pyogenes LTA through binding to the CD14 receptor, resulting in the signal transduction to TLR2/TLR6 being blocked. The LPS from Rhodobacter capsulatus PG can be considered a prototype for developing preparations to protect blood cells against the LTA of gram-positive bacteria.
DNA Methylation: Genomewide Distribution, Regulatory Mechanism and Therapy Target
Authors: Kaplun Daria S. , Kaluzhny Dmitry N. , Prokhortchouk Egor B. , Zhenilo Svetlana V.
Published: January 2023

DNA methylation is the most important epigenetic modification involved in the regulation of transcription, imprinting, establishment of X-inactivation, and the formation of a chromatin structure. DNA methylation in the genome is often associated with transcriptional repression and the formation of closed heterochromatin. However, the results of genome-wide studies of the DNA methylation pattern and transcriptional activity of genes have nudged us toward reconsidering this paradigm, since the promoters of many genes remain active despite their methylation. The differences in the DNA methylation distribution in normal and pathological conditions allow us to consider methylation as a diagnostic marker or a therapy target. In this regard, the need to investigate the factors affecting DNA methylation and those involved in its interpretation becomes pressing. Recently, a large number of protein factors have been uncovered, whose ability to bind to DNA depends on their methylation. Many of these proteins act not only as transcriptional activators or repressors, but also affect the level of DNA methylation. These factors are considered potential therapeutic targets for the treatment of diseases resulting from either a change in DNA methylation or a change in the interpretation of its methylation level. In addition to protein factors, a secondary DNA structure can also affect its methylation and can be considered as a therapy target. In this review, the latest research into the DNA methylation landscape in the genome has been summarized to discuss why some DNA regions avoid methylation and what factors can affect its level or interpretation and, therefore, can be considered a therapy target.
Análisis de cobertura en bosque secundario del Refugio Nacional Vida Silvestre Mixto Conchal, Costa Rica
Authors:   Universidad Nacional (UNA), Costa Rica, Sánchez-Toruño Henry Mauricio , Porras-Zuñiga Wilmer , Marroquin-Morales Pablo ,   Universidad Autónoma de Chiapas, México, Pequeño-Ledezma Miguel Ángel ,   Universidad Autónoma de Nuevo León, México, Hernández-Sánchez Gustavo ,   Universidad Nacional (UNA), Costa Rica, Montero-Flores William , Mesen-Montano Isaac
Published: January 2023

This study shows the behavior of passive regeneration in the secondary dry forest of the Conchal Mixed Wildlife Refuge. Whosepurpose was to characterize the floristic composition of the seedlings and saplings to determine the structure and potentialcomposition of the forest ecosystem within the Refuge. For the measurement of tall stilts (5 cm ≤ d ≤ 9.9 cm), 90 PermanentSampling Plots (PPM) of 10 m x 10 m (100 m2) each were evaluated for low stilts (height ≥ 1.5 m and d < 5 cm ) 5 m x 5 m (25m²) recording units were installed, and 2 m x 2 m plots for saplings (0.3 m ≤ height <1.5 m). Regarding the tall latizales, all theindividuals were measured and identified, and each one was classified according to its condition, crown exposure, canopy, crownshape and abundance of lianas; for low saplings and seedlings, only the species present were identified and quantified. Lowdiversity is found in the high latizales, where species such as Trichilia martiana and Guazuma ulmifolia have a high ecologicalweight due to their high percentages of abundance, dominance and frequency. In the low latizales and saplings the speciesMalvaviscus arboreus is the most abundant in the site. The execution of silvicultural techniques (refinement, devitalization,enrichment and release) and active restoration in the forest are required to increase the diversity of species.
Pago por servicios ambientales: esquemas y experiencias de éxito
Authors:   Universidad Autónoma de Nuevo León, México, Ruiz-González Juan Luis , Aguirre-Calderón Oscar A. , Jiménez-Pérez Javier , Treviño-Garza Eduardo Javier , Alanís-Rodríguez Eduardo
Published: January 2023

The present work carries out an analysis about the environment services, the different schemes, and his successful application inlocal and international markets. According to the compiled information, the successful in the implementation of environmentalservice scheme it caused for de soil use of the offer area and the environmental service type, also de flexibility in the contractsbetween de purveyor and the user. Is important considerer the not exclusion of the people who live in the poverty locations and thatneed the use soil for satisfied his basically needed
Fenología reproductiva e insectos polinizadores de Thelocactus bicolor (Galeotti ex Pfeiff.) Britton & Rose, en tres localidades de Nuevo León y San Luis Potosí, México
Authors:   Universidad Autónoma de Nuevo León, México, Pérez Silva Erick Raymundo , Cantú Ayala César , Uvalle Sauceda José I. , González Saldívar Fernando , Meléndez Jaramillo Edmar ,   Universidad Autónoma de Tamaulipas, México
Published: January 2023

The reproductive phenology of Thelocactusbicolor (Galeotti ex Pfeiff.) Britton & Rose, in addition to monitoring the insects thatinteracted with the flowers of this plant, located in the Botanical Garden Efraím Hernández Xolocotzi located in Linares, NuevoLeón, and in two nurseries for rescued plants located in Guadalcázar, San Luis Potosí, was registered. The study was carried out in2020, selecting and marking ten individuals located in 1 m², to evaluate the presence of their phenological stages (immature flower,intermediate flower, mature flower, immature fruit, ripe fruit, fruit in dispersion) through fortnightly sampling for a year,registering the activity and time in which arthropods interacted with the flowers of this cactus. The cacti began flowering in themonths of January and February at the three study sites. The mature flower stage only appeared in the Guadalcázar localitiestherefore, no insects were captured at the site located in Nuevo León. The Jacard similarity index showed a 50% of similaritybetween the registered arthropods of the Guadalcázar sites
UJI EFEKTIVITAS FORMULASI SEDIAAN SPRAY EKSTRAK DAUN NANGKA (Artocarpus heterophyllus L.) SEBAGAI REPELAN NYAMUK Aedes aegypti
Authors: Rahmawati Rahmawati , Marcellia Selvi , Nofita Nofita
Published: January 2023

Nyamuk Aedes aegypti merupakan vektor utama pada penyakit DBD yang sampai saat ini masih menjadi masalah besar pada kesehatan yang ada di Indonesia dan dapat menyerang semua orang mulai dari anak-anak hingga orang dewasa serta bisa mengakibatkan kematian. Untuk mengetahui karakteristik yang baik dan mengetahui berapa konsentrasi yang efektif dari sediaan spray ekstrak daun nangka sebagai repelan nyamuk Aedes aegypti. Pengamatan dilakukan selama 30 detik hingga 6 jam setelah perlakuan dan dihitung jumlah nyamuk Aedes aegypti yang hinggap. Data dianalisis dengan repeated measures Anova.  Pengamatan selama 30 detik pada ekstrak 1% memiliki nilai rata-rata 16,25%, pada ekstrak 5% memiliki nilai rata-rata 52,53%, pada ekstrak 9% memiliki nilai rata-rata 74,13%, sedangkan pada 6 jam setelah perlakuan 14,52% pada ekstrak 1%, 49,64% pada ekstrak 5%, 65,23% pada ekstrak 9%. Untuk kontrol positif pada 30 detik dan 6 jam mendapatkan nilai rata-rata 100% dan pada kontrol negatif pada 30 detik dan 6 jam memiliki nilai rata-rata 0% yang berarti kontrol negatif tidak memiliki kemampuan sebagai repelan nyamuk Aedes aegypti. Ketiga formulasi sediaan spray ekstrak daun nangka (Artocarpus heterophyllus L.) memiliki karakteristik organoleptis yang baik dan ketiga formulasi sediaan spray ini tidak ada yang efektif untuk dijadikan sebagai repelan nyamuk Aedes aegypti.
EVALUASI TINGKAT KEPUASAN PASIEN BPJS TERHADAP KUALITAS PELAYANAN INFORMASI OBAT DI PUSKESMAS HAJIMENA KABUPATEN LAMPUNG SELATAN
Authors: Peranginangin Martianus , Nofita Nofita , Rohana Fitri
Published: January 2023

Penelitian tentang Evaluasi Tingkat Kepuasan Pasien BPJS Di Instalasi Farmasi Puskesmas Hajimena Lampung Selatanbertujuan untuk mengetahui kepuasan pasien BPJS dan mengetahui kelengkapan pemberian informasi obat di instalasi farmasi Puskesmas Hajimena. Penelitian ini dilakukan dengan metode  deskriptif non eksperimental. Data dikumpulkan dengan survey menggunakan metode Cross Sectional. Penilaian terhadap kepuasan didapatkan dari hasil penyebaran kuesioner yang memuat 5 dimensi pelayanan kefarmasian. Analisis data menggunakan nilai kesenjangan rata-rata harapan dan rata-rata kinerja, persentase kesesuaian kepuasan pasien, dan Importance Performance Analysis. Jumlah sampel dalam penelitian ini adalah 98 responden. Hasil penelitian didapatkan nilai gap terbesar pada dimensi kehandalan yakni -1,36;  dimensi wujud/tampilan yakni -0,68; dimensi keyakinan -0,34; dimensi ketanggapan yakni -0,19 dan dimensi empati yakni -0,06 untuk nilai rata-rata persentase sebesar 88,12%. Hal ini menunjukan bahwa pasien rawat jalan sudah merasa puas dengan pelayanan yang sudah diberikan oleh petugas farmasi akan tetapi pihak puskesmas perlu memperbaiki apa yang menjadi harapan pasien yang belum tercapai guna meningkatkan mutu pelayanan kefarmasian.
pengaruh aromaterapi lemon terhadap frekuensi emisis gravidarum pada ibu hamil trimestr 1 di PMB wilayah kerja Puskesmas Pasar Kepahiang
Authors: Ramadhaniati Yuni , Wulandari Elza , Higriani Syahara
Published: January 2023

Apabila mual dan muntah terjadi terus menerus dan tidak diatasi dengan baik akan berlanjut menjadi hiperemesis gravidarum yang memiliki efek buruk bagi kesehatan ibu dan janin, sehingga dibutuhkan penanganan yang tepat untuk menangani mual muntah pada ibu hamil. Penelitian ini bertujuan untuk mempelajari pengaruh pemberian aroma terapi lemon terhadap emesis gravidarum pada ibu hamil trimester I di Praktik Mandiri Bidan Wilayah Kerja Puskesmas Pasar Kepahiang Tahun 2021.  Jenis penelitian Pre Eksperimental dengan the one group pretest - posttest. Populasi dalam penelitian ini adalah ibu hamil trimester I yang mengalami Emesis Gravidarum pada 14-31 Juli di Praktik Mandiri Bidan Wilayah Kerja Puskesmas Pasar Kepahiang. sampel berjumlah 11 ibu dengan menggunakan teknik Accidental sampling. Teknik pengumpulan data dengan data primer dan sekunder. Teknik analisis data dengan analisis univariat dan bivariat dengan uji Chi- Square (χ²), dan uji Contingency Coefficient (C). Hasil penelitian didapatkan bahwa sebelum intervensi 7 ibu dengan kategori sedang. Frekuensi minimal emesis gravidarum 3x dan makximal 11x dengan nilai rata-rata 5,64. Sesudah intervensi 9 ibu dengan kategori ringan. Frekuensi minimal emesis gravidarum 1x dan makximal 4x dengan nilai rata-rata 2,36. Uji statistik menggunakan uji paired sample T-Test didapatkan hasil nilai rata-rata frekuensi emesis gravidaram pada ibu hamil trimester I sebelum dan sesudah diberikan intervensi adalah 3,273 dengan standar deviasi 1,954. Hasil uji statistik di dapatkan nilai ρ value 0,000 maka dapat disimpulkan ada pengaruh yang signifikan pemberian terapi lemon pada ibu hamil trimester I dengan emesis gravidarum. Diharapkan hasil penelitian ini dapat diterapkan kedepannya dijadikan cara efektif nonfarmakologi dalam mengurangi emesis gravidarum pada ibu hamil
Analisis Kebijakan Deviden Tunai Dengan Likuiditas Sebagai Variabel Moderasi Pada Perusahaan Plat Merah Yang Terdaftar Pada Bursa Efek Indonesi
Authors: Kusuma Pramandyah Fitah , Purwaningsih Endah Supenin
Published: January 2023

Penelitian ini dilakukan untuk mengetahui apakah variabel independen yang terdiri dari profitabilitas yang diukur dalam Return on Investment, investment oportunity set yang diukur dalam Market Book to Value of Equity, serta Cost Politic yang diukur dalam Return On Asset berpengaruh terhadap variabel dependen yaitu kebijakan dividen tunai yang diukur dalam Dividend Payout Ratio, dan apakah Likuiditas sebagai variable moderasi dapat mempengaruhi hubungan tersebut, baik secara simultan maupun parsial. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kuantitatif, yaitu pengujian teori melalui pengukuran variabel penelitian dengan angka dan melakukan analisis data dengan prosedur statistik. Obyek penelitian menggunakan perusahaan plat merah (BUMN) yang terdaftar di Bursa Efek Indonesia selama periode penelitian yaitu 2015-2018, dimana pengambilan sampel didasarkan pada karakteristik yang telah ditentukan. Data yang digunakan adalah data sekunder yang didapat dari situs resmi BEI yaitu www.idx.co.id. Data diolah dengan program SPSS menggunakan alat uji regresi berganda dan regresi interaksi.
Analysis of Technical Errors Made by Motorcycle Riders
Authors: Homonnai Péter , Mándoki Péter
Published: January 2023

This article analyses road traffic accidents caused by motorcycle riders' technical errors. It presents an accident table that links the nature of the accidents to the causes of the accident. The connection provides a comprehensive overview of the typical motorcycle accidents that can be extended to events that have occurred. With this in mind, a conclusion can be drawn in the sense that an accident could have been avoided by a proper reaction of the motorcycle rider, and it would also make suggestions for developing a methodology for motorcycling education. Currently, motorcycling on the domestic road network is a hobby rather than a means of everyday travel, but the 10% participation rate in accidents certainly justifies the need to investigate this mode of transport. Today's state-of-the-art and technically well-equipped high-performance motorcycles require efficient vehicle handling and road use preparation. Therefore, drivers need to be able to respond appropriately to the challenges of our accelerated traffic.
Microcuenca del Río Magdalena Flora y Fauna: Guía de campo
Authors:   Universidad del Azuay, Nugra-Salazar Fredy , Segarra Oliver , Bustos-Cordero Ana María ,   Universidad del Azuay, Chaca Ronald ,   Universidad del Azuay, Llivigañay Mauro , Aguilar Juan Manuel , Zuña Liliana , Calle Oswaldo , Abad Diego
Published: January 2023

En esta oportunidad presentamos esta obra original con un enfoque artístico, tecnológico y científico que incluye descripciones, los nombres científicos, familias, órdenes, estatus, distribuciones e ilustraciones de las especies de mamíferos, aves, anfibios, flora, líquenes y peces que habitan el Área de Conservación Municipal y Uso Sustentable de la Microcuenca del Río Magdalena, Subcuenca del río Cutilcay, ubicado en la parroquia Bulán del cantón Paute. Este documento está escrito en dos idiomas, español e inglés. Asimismo, la guía cuenta con códigos QR que al ser escaneados, brindarán información complementaria sobre cada especie. Esperamos que esta guía ilustrada ayude a la divulgación de conocimientos, así como a la conservación de la flora y fauna del Área de Conservación Municipal. 140 páginas ISBN: 978-9942-847-41-6 EISBN: 978-9942-847-42-3
Respon Pertumbuhan dan Hasil Tanaman Bunga Kol Akibat Pemberian dan Konsentrasi PGPR
Authors: Hartanti Aprilia , Suyani Ida Sugeng , Wahyudi Nanang
Published: January 2023

Dalam penelitian ini diharapkan dapat mengetahui respon pertumbuhan dan hasil tanaman bunga kol akibat pemberian dan konsentrasi PGPR. Hasil penelitian yang diperoleh yaitu: 1) Konsentrasi PGPR tidak memberikan dampak berupa respon pada pertumbuhan dan hasil, 2) pemberian PGPR berpengaruh nyata pada terhadap pertumbuhan dan hasil pada tanaman bunga kol, 3)Tidak terjadinya interaksi antara pertumbuhan dan hasil tanaman akibat pemberian dan konsentrasi PGPR. Metode penelitian yang digunakan yaitu RAK, dalam 2 faktorial yaitu faktor I adalah konsentrasi PGPR yang diberikan dengan 4 taraf perlakuan dan faktor II saat pemberian PGPR dengan 3 taraf perlakuan sehingga menghasilkan sebanyak 36 percobaan dengan rincian 3 kali pengulangan dari 12 kombinasi percobaan yang dilakukan. Data akan dianalisis melalui uji BNT sebesar 5% untuk faktor tunggal dan uji jarak Duncan (DMRT) sebesar 5% untuk faktor interaksi.
Implementasi Pewarnaan Graf Menggunakan Metode Algoritma Tabu Search Pada Penjadwalan Kerja Perawat
Authors: Sari Rina Filia , Rakhmawati Fibri , Nur Lela
Published: January 2023

Penjadwalan kerja perawat khususnya keperawatan dirumah sakit sering menjadi suatu masalah yang dihadapi oleh setiap rumah sakit.  Hal ini dikarenakan banyaknya persoalan dan adanya batasan-batasan yang harus dipenuhi. Selama ini RSUD Drs. H. Amri Tambunan masih menggunakan cara manual dalam menyusun jadwal kerja perawat sehingga sering mengalami kesulitan dan jadwal kerja yang dihasilkan pun masih belum merata dan teratur. Permasalahan penjadwalan ini dapat diselesaikan dengan pewarnaan simpul graf.iSalah satu algoritma untuk menyelesaikan masalah pewarnaan verteks graf pada penjadwalan adalah Algoritma Tabu Search. Algoritma Tabu Search adalah salah satu metode pemecahan permasalahan optimasi kombinatorial. Metode ini bertujuan untuk mengefektifkan proses pencarian solusi terbaik dari suatu permasalahan. Maka dapat diperoleh kesimpulan bahwa Algoritma Tabu Search dapat diterapkan untuk menyelesaikan masalah penjadwalan perawat dirumah sakit, salah satunya di RSUD Drs. H. Amri Tambunan. Penerapan Pewarnaan simpul dengan menggunakan Algoritma Tabu Search menghasilkan penjadwalan perawat yang lebih efisien dimana tidak ada terjadi jadwal yang bentrok, artinya tidak ada perawat yang mendapat dua shift di hari yang sama.
Azərbaycan dilində hibrid sözlər
Authors: Haciyeva Nergiz
Published: January 2023

Azərbaycan ədəbi dilinin lüğət tərkibinin inkişaf problemi müasir dilçilikdə əhəmiyyətli yer tutur və müxtəlif mənşəli sözlərin yeni söz yaratma problemi ilə əlaqədardır. Son vaxtlar dilçilikdə Azərbaycan dilində alınma leksikanın inteqrasiyası məsələsi xüsusi maraq doğurur. Bu zaman ingilis dilinin lüğət tərkibindən alınan sözlərə xüsusi əhəmiyyət verilir, belə ki, ingilis dili təkcə Azərbaycan dili üçün deyil, o cümlədən dünyanın bir sıra dilləri üçün donor rolu oynayır. Müasir dövrdə ingilis-Azərbaycan hibridlərinin yaranması ən qeyri-ordinar və mürəkkəb sözdüzəltmə proseslərindən biridir, bu zaman yeni yaranan sözlər yalnız yumoristik məqsədlə, yenilik, gözlənilməzlik, ahəngdarlıq ilə deyil, həm də ifadənin yüksək informativliyi ilə seçilir. Hibrid söz mənşəcə yunan sözü olub, çarpazlaşmış, qarışmış deməkdir. Qeyd etmək lazımdır ki, iki eyni mənalı sözün birləşib hibrid söz yaratması cəhətdən hibrid sözlər leksikpleonazm hadisəsini yaradır. Məsələn: Türk mifologiyasında itbarak mifoloji surətlərdən biridir; İlk mərhələnin şərti başdan-binadan belə qoyulmuşdu : “Laldinməz” (S.Azəri. “Yasaq edilmiş oyun”); -Sağ olsun qılçalarım, -deyirdim, - uzundraz oğlanam (İ.Əfəndiyev. “Sarıköynəklə Valehin nağılı”); Bulud göydə düzüm-düzüm düzülür, Get gözəl, səfərin mübatrək olsun. Gözlərimdən abi-neysan süzülür, Get gözəl, səfərin mübarək olsun (A.Padarlı, “Olsun”); Döğrudanmı hələ özünü tanımayan, yaxud özünü tapmayan, bəlkə də Avropanın “ifrat azadlığı”nda özünü itirən iki cüt bir tək növcavanın və uğursuz “hüquq müdafiəçisi”nin təhqirlərinə dözməliyik? (“Gündəm”, Ə.Nuriyev). Bir dilin sözlərinin digərinə keçmə masştabı dildaxili əlaqələrin xarakterindən də asılıdır: daxili və xarici kontaktlar şəraitində bu proseslərin səbəbi adətən müxtəlif olur. Birinci halda “mədəni” alınmalar üstünlük təşkil edir, eyni zamanda daxili kontaktda digər motivlərin bütöv cərgəsi fəaliyyət göstərməyə başlayır. Alınma kök morfemlərin əksəriyyətinin üzə çıxması ikidillilik şəraitində onların sözdüzəltmə proseslərinə cəlb olunması ilə əlaqədardır. Yeni sözləri qəbul edən dildə yeni yaranan sözlərin seriyası meydana çıxır ki, onlar alınma kökdən və xüsusi sözdüzəltmə şəkilçisindən ibarət olur. Beləliklə, Azərbaycan dilində hibrid sözlər münasibətdə bir neçə fikir irəli sürülür: 1) iki eyni mənalı sözün birləşməsi və yaxud yanaşı işlənməsi kimi; 2) qoşa söz modelində işlənən hibrid sözlər; 3) hibrid sözlərə ayrı-ayrı dillərə məxsus şəkilçilərin qoşulması ilə; 4) hər iki sözün ixtisarı şəklində. Hibrid sözlər universal olaraq bütün dillərdə mövcuddur. Cəmiyyətin iqtisadi, siyasi, mədəni həyatında bir-biri ilə qarşılıqlı əlaqədə olan dillərin lüğət tərkibi hibridləşməyə məruz qalır
SARS-CoV-2-Related Multisystem Inflammatory Syndrome in an Immunocompromised Child with Osteosarcoma Revealed by Hepatocellular Failure
Authors: K Ryouni , I Chahid , M Atrassi , D Bensabbahia , A Abkari
Published: January 2023

Introduction: Multisystem Inflammatory Syndrome in Children (MIS-C) is a new phenomenon reported worldwide with temporal association with COVID-19. Objective: The aim of our case report is to clarify the manifestations of a pims syndrome in a osteosarcoma field, which can be confused with metastases. Patients and methods: We report a case of a 12-year-old male patient followed for osteosarcoma of the right humerus who was admitted for hepatocellular failure with cutaneous-mucosal jaundice revealing a PIMS syndrome. Results: The patient had initially received 3 courses of chemotherapy, followed by monobloc resection of the tumour mass and osteosynthesis, who met the case definition of PIMS-TS presented with fever, multi organ and mucocutaneous involvement, cardiovascular and gastrointestinal symptoms. His biological work-up showed a significant inflammatory syndrome with very high ferritin levels, high D-dimer and pro-BNP levels, associated with lymphopenia and liver cytolysis. An echocardiogram revealed a dilated cardiomyopathy with an LVEF of 13% associated with a moderate pericardial effusion. The work-up was completed by a PCR covid which came back negative, when the serology came back positive confirming a PIMS-TS. Therapeutically, he received a course of immunoglobulin, corticosteroid, and in view of the myocardial damage, he was put on Aspirin, ACE inhibitor, beta-blocker and spironolactone after normalization of his blood pressure. The evolution was spectacular, marked by a clear clinical improvement, the normalisation of biological parameters and the improvement of his LVEF on echocardiography. Conclusion: Although the pathogenesis is not clearly known, immune-mediated injury has been implicated. We herein provide current information on this condition, in order to raise awareness amongst pediatricians.
A Correlation Study of Liver Biopsy Appearances, Serum HBV DNA and HBsAg Quantification Levels of Nigerian Patients with Chronic Liver Disease
Authors: O.A Betiku , O Adekanle , D.A Ndububa , O.S Ojo
Published: January 2023

Background: Infection with the hepatitis B virus is highly endemic in much of sub-Saharan Africa where it remains an important cause of chronic ill-health. Quantitative assay of HBV DNA and HBsAg are emerging as useful tools in the management of chronic HBV infection. However, it is not yet clear how well each of these might accurately correlate with the extent of liver damage during the course of the disease. Nevertheless, liver biopsy, albeit an invasive test, affords a superior direct assessment of all stages of the disease. Objective: Thus, we set out to determine how well-correlated serum levels of HBV-DNA and/or HBsAg might be with each other and with the liver biopsy appearances. Methodology: This study was prospective and we enrolled, 83 new treatment-naïve patients, who met the study criteria. Each patient had liver biopsy assessments of the grade of necroinflammation (A) and stage of fibrosis (F), according to the METAVIR Scoring System. In addition, quantitative HBsAg serum levels by immunoassay and HBV DNA by real-time quantitative PCR protocols were made. The Spearman’s and Kruskal-Wallis statistical tests were employed to determine the correlations between these assays separately and with the respective histological grades and stages of liver biopsy. (p=0.05) Results: The greatest number of the patients were within the 21-40 year- age group. Using the Spearman rho’s statistical correlation test, we found a positive but weak correlation between the serum HBsAg and HBVDNA levels (p=0.075, r=0.198). The Kruskal-Wallis analysis revealed statistically significant correlation between HBV-DNA and the grade of necroinflammation but not with the stage of fibrosis. Conclusions: We found that the serum HBV DNA levels had the only statistically significant correlation with the liver histological disease. This relationship needs to be further examined in larger studies in the future.
Patterns of COVID-19 Vaccination and Protective Equipment Usage in Endoscopy: A Survey of Endoscopy Providers
Authors: Chow Kenneth W , Bell Matthew T , Nguyen Phoenix , Krinsky Mary L , Reicher Sofiya
Published: January 2023

Background: Endoscopic procedures have an increased risk for COVID-19 transmission due to their production of respiratory droplets and aerosolized particles. Early case reports and surveys suggest that transmission risk during endoscopy is low given proper personal protective equipment (PPE) usage. However, the advent of new virus variants led to renewed concern regarding infection risk. We examined how these recent trends have affected patterns of COVID-19 positivity, endoscopy center pre-procedure screening protocols, PPE usage, and healthcare provider perceptions of safety in endoscopy. Methods: We surveyed gastroenterologists, nurses, technicians, and other endoscopy unit personnel throughout the United States. The survey was sent on November 1, 2021 and November 15, 2021. Results: Seventy-two individuals responded to the survey with a self-reported vaccination rate of 100%. Nine individuals (13%) reported testing positive for COVID-19, all of whom tested positive before vaccination. Fifty-one (71%) endoscopy workers received the booster dose, and 13 (18%) endoscopy workers planned to in the future. Seven (10%) had not received a booster dose and did not plan to, even if available. Fortythree (60%) individuals reported that their endoscopy center mandated routine COVID-19 testing for all patients undergoing endoscopy. Sixty-one respondents (85%) reported feeling safer performing endoscopic procedures after vaccination. Conclusion: In our cohort, most endoscopy workers received the booster dose or planned to once available, and most reported feeling safer during endoscopy post-vaccination. Although the American Gastroenterological Association had recommended against routine COVID-19 screening prior to elective endoscopy, 60% of respondents reported that their endoscopy center mandated routine pre-procedural screening. Even with the advent of the highly transmissible Delta variant in early 2021, COVID-19 transmission during endoscopy remained low given vaccination and proper PPE utilization. Further data is needed to shape practicechanging guidelines regarding booster vaccine mandates and pre-procedural screening in high-risk fields such as endoscopy.
A Comparative Nutraceutical Analysis of Edible Solanum L. Species Reported in India.
Authors: Balkrishna Acharya , Shankar Rama , Joshi Rashmi A , Prajapati Uday Bhan , Srivastava Anupam , Vidyarthi Pooja , Lathwar Ridhi , Arya Vedpriya
Published: January 2023

The Genus with its 1234 species has worldwide distribution and is native to almost all continents, except several parts of Canada, Arctic and Antarctica poles. The species are widely used for vegetable and medicines. Various species of Solanum are herbs, climbers, undershrubs, shrubs and trees. From India, 64 species have been reported inclusive of cultivars, out of which 16 species possess medicinal properties Species like Solanum lycopersicon, S. melongana, S. spirale, S. tuberosum are widely used as vegetable and other supplementary food recipes whereas in the traditional culture of Northeast India, S nigrum, S. torvum, S. tuberosum, S. violaceum are used as vegetable with the concept of digestion and worm infestation in different names and the natives adapted the cultivation of the concern species in their kitchen gardens for self and family use. To serve the purpose, shoots of S. nigrum and berries of other species are being used whereas in Ayurvedic system of medicine, S. nigrum is described for the preparation of liver related medicines like Kakamachi Ghrit.
Pediatric Insomnia Disorder: Treatment Options beyond Melatonin
Authors: Kaur Mandeep , Agrawal Sabhyata
Published: January 2023

Objective: Pediatric insomnia disorders significantly affect the lives of the patients and their caregivers. Currently available behavioral management techniques and therapy are not effective for everyone. There is extensive literature on the efficacy and safety data on melatonin however, it too can be ineffective for some patients. The aim of this narrative review is to provide an analysis of various pharmacological and nonpharmacological options, other than melatonin, that can be considered as treatment options for pediatric insomnia. Methods: The databases PubMed, Medline, Scopus were searched using the key terms “pediatric insomnia”, “insomnia in children”, “insomnia in adolescents”, “therapies in pediatric insomnia”, “behavioral management of pediatric insomnia, “pharmacological agents in pediatric insomnia”, “complementary treatment of pediatric insomnia”, and “herbal therapies in pediatric insomnia” which yielded 128 articles. Additionally, database clinicaltrials.gov was searched for trials with key words “insomnia in children”, “insomnia in adolescents” and “pediatric insomnia” which yielded 42 studies. The articles and studies were reviewed as pertinent to the topic. Results: Based on the search, evidence for effectiveness for several novel therapeutics such as melatonin agonists, orexin receptor antagonists, nutritional supplements, herbal medicines, complementary and alternative treatment options came in to light. However, a remarkable deficit of large-scale studies depicting the efficacy and safety of all these in pediatric populations was noted. Conclusions: With pediatric insomnia disorders being a challenging clinical situation for clinicians not just limited to one specialty, a joint effort is needed to explore these treatment options with help of large-scale clinical studies.
Potential Risk of Nanotechnology Radioactive Materials for Diagnostics
Authors: Umeukeje Gibret , Sneed Kevin , Pathak Yashwant
Published: January 2023

The manufacture of personalized, real time, specific, and sensitive diagnostic tools continue to be of importance as the need for rapid diagnosis and monitoring of disease persists. In many health conditions like cancer and Covid-19 infection timely diagnosis of diseases can affect chances of survival. The accurate and timely diagnosis of diseases is enhanced by the unique optical, fluorescent, and magnetic properties of nanoscale elements. However, ultra-fine Nano particles unintentionally released into the air through human activities like combustion have been linked to respiratory and cardiovascular diseases. This makes it important for Nano engineered devices to be assessed for safety and toxicity concerns. Toxicity studies on the bulk material of the nanoscale elements used in diagnosis does not suffice as Nano materials due to their small size have unique interactions with biological membranes. Radioactive functionalized nanoparticles have been employed in several diagnostic imaging techniques such as Positron Emission Tomography, Magnetic Resonance Imaging, Computed Tomography, and Optical Imaging. These radioactive nanoparticles provide many benefits over conventional contrast agents including their theranostic ability. Spherical gold nanoparticles used in vivo for CT imaging have shown a 3-fold higher X ray attenuation than an iodine-based contrast agent. The tremendous benefits associated with use of radioactive functionalized nanoparticles calls for study of the risks associated with them as more and more radioactive nanotechnology-based products are employed in health care. Radioactive functionalized nanoparticles should be assessed for safety in both their radionucleotide component and nanomaterial component. Recent studies of nanoparticles have shown that they can lead to DNA damage by generation of Reactive Oxygen Species (ROS). Some of the discovered factors that play a key role in the generation of ROS include size, composition, surface charge, and shape. Understanding of the method of different radio nucleotide nanoparticle toxicity, the extent to which it causes toxic effects, and factors involved in its toxicity can help manufacturers reduce or eliminate their toxic profile while maximizing their benefits.
Identification and anti-viral activities of butanolide skeleton from Cinnamomum kotoense and Cinnamomum subavenium by inhibiting H5N1 neuraminidase
Authors: CT Chang , CM Liu , HC Yeh , WJ Li , HT Li , CY Chen , SL Liu
Published: January 2023

The human influenza virus and avian influenza virus represents a serious threat to human health. Although zanamivir and oseltamivir against influenza virus neuraminidase and thus the viral replication is not available. The oseltamivir-resistant H5N1 virus has been isolated from patient. Moreover, several cases have been reported where patients developed adverse symptoms due to a long-term use of oseltamivir. Effective antiviral drugs are essential for early control of an influenza pandemic. Natural products have been used as important resources for medicine and healthy food to improve the quality of life. Cinnamon bark is widely used as a spice and herb medicine. In this study, we have isolated and identified three butanolide derivatives, kotomolide A, isolinderanolide B and linderanolide B from Cinnamomum kotoense and Cinnamomum subavenium. Further, enzyme-based screening and anti-viral activity were also examined. Our study provides a starting point for developing new therapeutic or preventive agents from natural products for avian influenza virus.
Immunohistochemical Effects of Ethyl Acetate Fraction of Lycopersicum Esculentus on the Kidney in Experimentally Induced Diabetic Wistar Rats
Authors: Arayombo Babatunde Elijah , Adewole Olarinde Stephen
Published: January 2023

Diabetic nephropathy (DN) as a leading cause of end-stage renal failure which has become source of concern recently. The aim of this study was to investigate the effect of EAFL on the histomorphology and evaluate its effect on inflammatory markers in Streptozotocin- Induced diabetic Wistar rats. This study was conducted using thirty male Wistar rats. The animals were divided into five groups of 6 rats each (n=6). Group A was the control animals ( administered with 20 ml/kg/day of citrate buffer orally (p.o) stat for 4 weeks. Group B was induced with 65 mg/kg of streptozotocin in citrate buffer intraperitoneally stat and observe for four weeks without treatment. Group C,D and E were the test groups that received 65 mg/kg of streptozotocin in citrate buffer intraperitoneally stat and 20, 40 and 60 mg/kg/day of EAFL respectively for four weeks after induction of diabetes. Descriptive and inferential statistics were used to analyze the data. The results showed reduction in serum insulin levels in diabetic groups which was reversed to normal when the intervening agent (EAFL) was administered. The histology of the kidneys showed distortion in renal corpuscles which was reversed when EAFL was administered. The immunohistochemistry of kidney tissues in the normal group (A) showed areas of Ag-Ab immunological reactivity, however, there was no reactivity in the diabetic groups. The study concluded that EAFL has anti glycemic and anti inflammatory effect on the kidneys of Streptozotocininduced diabetic Wistar rats.
A Perspective on Needs Identification for Successful Cardiovascular Device Innovation
Authors: Goldenberg Elizabeth , Pedersen Wesley
Published: January 2023

A compelling “need” identification is essential prior to initiating the lengthy, demanding and often frustrating pathway necessary for cardiovascular device innovation and development. Over the past few decades both iterative and transformational treatments have been especially profound in cardiovascular interventional and surgical approaches which have necessitated innovation in devices to bring these novel approaches to fruition. Stakeholders in the development of such devices have included amongst others, clinicians, patients and institutions. Given the numerous hurdles for medical device development including the need for multidisciplinary teams, establishing intellectual property portfolios, conducting market in tandem with academic research, funding, identifying regulatory and reimbursement strategies, a rigorous process for needs verification is mandatory. This vital first step needs to be methodical and is the topic of brief discussion in this perspective manuscript.
Metastasis to the oral cavity: a systematic review
Authors: Macedo Larissa Fernanda dos Santos Lima , Falcão André Pereira , Campos Wladimir Gushiken de , Lemos Júnior Celso Augusto , Miguita Lucyene , Domaneschi Carina
Published: January 2023

The present study proposed to systematically review case reports of metastasis to the oral cavity and compile epidemiological, clinical, radiological, and histopathological features, intending to identify common aspects that may favor early diagnosis of such condition. Articles were found by searching the following databases: PubMed; EMBASE; LIVIVO; Web of Science; LILACS; Scopus and SciELO. The search was carried out in March 2021 by two independent researchers, with no restrictions of publication date or language. A total of 2379 studies were retrieved and 60 articles completely matched inclusion criteria, totalizing 65 cases from 19 countries. Metastasis to oral cavity cases were slightly frequent in males (1.7:1) in the sixth decade of life, manifesting in oral soft tissues (58%, 37/65), mostly originated from the lungs (20%, 13/65) as primary site. Adenocarcinoma was the most reported type of malignacy. In 51% of cases the oral metastatic lesion was the first sign of cancer and 60% of the patients already presented metastasis to other locations. In 23% of the reports, only benign lesions were considered as diagnostic hypothesis, due to a remarkable clinical resemblance to hyperplastic, reactive lesions and odontogenic infections. The survival probability at 6 months after oral metastasis diagnosis was 49%. Metastatic lesions to the oral cavity are often misdiagnosed as benign lesions; due to its severity and quick progression, they must be considered in the differential diagnosis process, conducted by a multidisplinary healthcare team comprising an oral surgeon, especially for patients with history of cancer.
Efetividade de fontes e doses de silício para o crescimento, pigmentos fotossintéticos e teor de cardenolideos em Digitalis mariana Boiss subsp. Heywoodii in vitro
Authors: Moura Raíssa Couteiro , Assis Rafael Marlon Alves de , Rocha João Pedro Miranda , Leite Jeremias José Ferreira , Pereira Flávia Dionisio , Santos Jandeilson Pereira dos , Bertolucci Suzan Kelly Vilela , Pinto José Eduardo Brasil Pereira
Published: January 2023

Digitalis mariana (Plantaginaceae) é considerada nativa do Oeste, Sudoeste e Centro-oeste da Europa. É uma espécie de interesse medicinal, dado principalmente por seusglicosídeos cardiotônicos usados no tratamento de insuficiência cardíaca. Modificações no meio de cultivo podem ser realizadas para melhorar o cultivo in vitro. Tem sido relatado que o crescimento e desenvolvimento de plantas são afetadas pela aplicação de Silício. Desta forma, objetivou-se avaliar o crescimento, teor de cardenolídeos totais e pigmentos fotossintéticos em D. mariana cultivadas sob diferentes fontes e doses de Silício em meio de cultura. O material vegetal foi estabelecido in vitro. Após esse processo, foram testadas três fontes de Silício: silicato de Potássio, de Cálcio e de Sódio nas concentrações de 0, 0,5, 1,5, 4,5, 7,5, 10,5 mg L-1. Após 40 dias foi realizado a validação analítica e foram avaliados o crescimento, pigmentos fotossintéticos e cardenolídeos totais. As diferentes fontes e concentrações promoveram crescimento de parte aérea e raízes, aumentaram os teores de clorofila a, clorofila b, carotenoides e de cardenolídeos. O uso de 0,5 mg L-1 de silicato de sódio promoveu maior biomassa seca da folha e total. Silicato de cálcio e silicato de potássio na concentração de 4,5 mg L-1 promoveram maiores teores de cardenolídeos. O cultivo de D. mariana sob fontes de Silício em concentrações diferentes mostra-se uma técnica promissora para a otimização da produção de mudas e metabólitos secundários.