bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between prenatal and neonatal risk factors and development of bronchiolitis in early life
Authors: Chen Po-Sung , Tsai Yi-Fen , Yu Hong-Ren , Hung Chih-Hsing , Chen Wei-Yu , Lin Ching-Wei , Lee Ju , Chen Chih-An , Tsai Hui-Ju , Wang Jiu-Yao
Published: February 2024

Background:

Bronchiolitis is the most common seasonal viral respiratory disorder in infants. However, risk factors for the development of bronchiolitis, particularly during pregnancy, remain unclear.

Methods:

A questionnaire was administered to the parents of the hospitalized infants with acute bronchiolitis to obtain information regarding patients’ medical, family, and prenatal exposure history. Logistic regression with adjustment was performed to evaluate risk factors associated with bronchiolitis in the infants.

Results:

Among the enrolled patients, 55 (36.7%) were diagnosed as having bronchiolitis, and the majority (89%) of the patients had moderate-to-severe bronchiolitis. The bronchiolitis group had lower C-reactive protein levels than did the control group. Fewer patients in the bronchiolitis group developed fever. However, hospital stays were longer in the bronchiolitis group than in the control group. Respiratory syncytial virus was the most detected virus (23/26, 88.6%) in the bronchiolitis group. Male sex (odds ratio [OR], 5.71; 95% confidence interval [CI], 2.02–16.12; P < 0.001), antibiotic usage during pregnancy (OR, 27.2; 95% CI, 1.12–660.84; P = 0.04), and viral infection (OR, 49.3; 95% CI, 9.01–270.26; P < 0.001) during the postnatal period were significantly associated with hospitalization for acute bronchiolitis in the infants. By contrast, pet exposure during the perinatal period was significantly and negatively associated with acute bronchiolitis (OR = 0.21, 95% CI = 0.07–0.69, P < 0.01).

Conclusion:

Environmental exposures during pregnancy may affect respiratory health in offspring, and effective strategies should be developed to prevent bronchiolitis in early life.
The epithelial barrier theory: development and exacerbation of allergic and other chronic inflammatory diseases
Authors: Kucuksezer Umut Can , Ozdemir Cevdet , Yazici Duygu , Pat Yagiz , Mitamura Yasutaka , Li Manru , Sun Na , D’Avino Paolo , Bu Xiangting , Zhu Xueyi , Akdis Mubeccel , Nadeau Kari , Ogulur Ismail , Akdis Cezmi A.
Published: February 2024

It is now longer than half a century, humans, animals, and nature of the world are under the influence of exposure to many newly introduced noxious substances. These exposures are nowadays pushing the borders to be considered as the causative or exacerbating factors for many chronic disorders including allergic, autoimmune/inflammatory, and metabolic diseases. The epithelial linings serve as the outermost body’s primary physical, chemical, and immunological barriers against external stimuli. The “epithelial barrier theory” hypothesizes that these diseases are aggravated by an ongoing periepithelial inflammation triggered by exposure to a wide range of epithelial barrier–damaging insults that lead to “epithelitis” and the release of alarmins. A leaky epithelial barrier enables the microbiome’s translocation from the periphery to interepithelial and even deeper subepithelial areas together with allergens, toxins, and pollutants. Thereafter, microbial dysbiosis, characterized by colonization of opportunistic pathogen bacteria and loss of the number and biodiversity of commensal bacteria take place. Local inflammation, impaired tissue regeneration, and remodeling characterize the disease. The infiltration of inflammatory cells to affected tissues shows an effort to expulse the tissue invading bacteria, allergens, toxins, and pollutants away from the deep tissues to the surface, representing the “expulsion response.” Cells that migrate to other organs from the inflammatory foci may play roles in the exacerbation of various inflammatory diseases in distant organs. The purpose of this review is to highlight and appraise recent opinions and findings on epithelial physiology and its role in the pathogenesis of chronic diseases in view of the epithelial barrier theory.
Drug-induced Stevens Johnson syndrome and toxic epidermal necrolysis: Interpreting the systematic reviews on immunomodulatory therapies
Authors: Thong Bernard Yu-Hor
Published: February 2024

Drug-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are non-immunoglobulin E-mediated severe cutaneous adverse reactions with a high risk of morbidity, mortality, and physical and mental health impact. These are associated with certain high-risk drugs, human leukocyte antigen (HLA)-specific genotypes and ethnicities. HLA class I–restricted oligoclonal CD8 cytotoxic T-cell responses occur at the tissue level in SJS/TEN. Cytotoxic T cells are the T effector cells that result in keratinocyte apoptosis (cell death) mediated by T effector molecules granzyme B, perforin, granulysin, gamma interferon, tumor necrosis factor-alpha, and lipocalin-2. The clinical hallmarks of SJS/TEN include fever, ≥2 mucosal involvements (ocular, oral, and genital), and positive Nikolsky sign with epidermal detachment. Systematic reviews on immunomodulatory treatments remain limited by the paucity of randomized controlled trials, heterogeneity of studies, and non-standardization of outcome measures. Preventive HLA genotype screening before the prescription of carbamazepine and allopurinol may further reduce the incidence of SJS/TEN. The role of immunomodulatory treatments in SJS/TEN is at present not supported by robust evidence from systematic reviews given the lack of randomized controlled trials. The evidence for improved survival with off-label use of corticosteroids plus intravenous immunoglobulins, ciclosporin plus intravenous immunoglobulins, and ciclosporin alone has not been demonstrated by network meta-analyses and meta-regression. In the real-world clinical setting, systemic corticosteroids (in SJS and overlap SJS/TEN), ciclosporin, and etanercept (in TEN) appear to be the off-label treatments currently most widely used.
Real-world physician practices on the diagnosis and management of allergic rhinitis in the Philippine setting
Authors: Balotro-Torres Maria Cristina V. , Tan Frances M. , Navarro-Locsin Cecilia Gretchen , Recto Marysia T. , Romualdez Joel A. , Ramos Josephine B. , Resurreccion Emily G. , Lobo Rommel Crisenio M. , de Guia Eloisa S. , Carreon-Asuncion Ma. Fredelita , Bousquet Jean
Published: February 2024

Background:

Physician awareness and adherence to guidelines varies among countries and between types of physician practice. Identifying the needs of the physician and patient is essential to improve patient outcome. Data on physician diagnosis and management of allergic rhinitis (AR) in the Philippines is currently limited.

Objective:

Study objectives are to assess awareness and use of guidelines, practices on diagnosis and management of intermittent and persistent AR, reasons for choice of therapy, and familiarity with immunotherapy.

Methods:

A cross-section of 590 specialist and 223 subspecialist physicians from 17 regions of the Philippines were surveyed from October 2021 to July 2022. Survey consisted of a 12-point validated online questionnaire on knowledge and use of guidelines for diagnosis and treatment, use of diagnostic tests, preferred pharmacologic treatment, preferred adjuvant therapy, reasons for treatment choice, and familiarity with immunotherapy.

Results:

Seventy-seven percent of respondents used Allergic Rhinitis and its Impact on Asthma guidelines for diagnosis and management of AR. Three-fifths of respondents “always” routinely evaluated AR patients’ history and performed a physical examination for asthma; 57% of respondents “always” routinely evaluated asthma patients’ history and performed a physical examination for AR. Allergy testing was “sometimes” recommended by 62.2%. Oral second-generation antihistamines were the preferred choice for the treatment of intermittent AR. Intranasal steroids were the preferred treatment for persistent AR. Top reasons for choice of treatment were guideline recommendations, efficacy, onset of action, cost, and availability of treatment.

Conclusion:

Filipino specialists and subspecialists are aware and use guidelines in diagnosis and management of AR. Clinical history and physical examination are the cornerstone of diagnosis. Management practices for intermittent and persistent AR are similar for both groups. Recognizing the role of patient treatment preferences and allergen-specific immunotherapy remains to be a gap in the management of AR by Filipino physicians.
Application of nasal irrigation in the treatment of chronic rhinosinusitis
Authors: Jin Ling , Fan Kai , Yu Shaoqing
Published: February 2024

Nasal irrigation (NI) for the local treatment of chronic rhinosinusitis (CRS) has some specificity due to the deep anatomical site of the sinuses. The purpose of this review is to help standardize the application of NI in healthcare practice, improve the prevention and treatment of CRS, and facilitate further research on the local treatment of CRS in the future. We searched the PubMed database for 342 articles in the last decade, using the keywords “saline nasal irrigation” and “chronic rhinosinusitis.” We summarize the studies on the mechanism of action, rinsing solution, rinsing apparatus, and rinsing method of NI for CRS. NI plays an important role in the treatment of CRS, and it is a beneficial low-risk treatment. Isotonic saline is the most accepted flushing solution, and large-volume low-pressure flushing bottles are the flushing devices with the best flushing effect and are generally tolerated by patients. Phage, colloidal silver, and hydrogen can be further studied as components of rinses. NI plays an important role in the treatment of CRS, and it is a beneficial low-risk treatment. Further high-quality and expanded sample size studies on other flushing solutions, flushing head position, flushing frequency, and treatment courses are still needed, and lessons learned in practice.
Immunological mechanisms of tolerance: Central, peripheral and the role of T and B cells
Authors: Meng Xun , Layhadi Janice A. , Keane Sean T. , Cartwright Natanya J.K. , Durham Stephen R. , Shamji Mohamed H.
Published: February 2024

T and B cells are key components of the adaptive immune system. Through their immune properties and their interactions with other immune cells and cytokines around them, they build a complex network to achieve immune tolerance and maintain homeostasis of the body. This is achieved through mechanisms of central and peripheral tolerance, both of which are associated with advantages and disadvantages. For this reason, the immune system is tightly regulated and their dysregulation can result in the subsequent initiation of various diseases. In this review, we will summarize the roles played by T cells and B cells within immune tolerance with specific examples in the context of different diseases that include allergic disease. In addition, we will also provide an overview on their suitability as biomarkers of allergen-specific immunotherapy.
On The Minimal Sets and Stability Conditions For Compact Sets In I(X)-spaces
Authors:   Mustansiriah University, Department of Mathematics, Iraq, Obaidi Murhaf
Published: February 2024

The set of all isometries on a metric space X with the usual composition of functions form a group and it is called the group of isometries and is denoted by I(X). In this paper we study the generalization of the concepts of minimal sets, stability and attraction, from dynamic system into the topological transformation group (I(X),X).We find that the collection of all minimal sets of I(X)-space is the collection of all the closures of orbits of X and we found some useful results about stability and attraction and we fixed the relationship among it's kinds.
Dos conquistas más, camino a más indexaciones
Authors: Urriago Fontal Juan Carlos
Published: February 2024

Después de  haber sido incluida en el catálogo 2.0 de Latindex  y en el Directorio  de  Revistas  de  Acceso Abierto  (DOAJ),  Magna  Scientia  UCEVA  logra  dos nuevas indexaciones en importantes índices: MIAR, la Matriz de Información para el Análisis de Revistas, un sistema desarrollado por la Universidad de Barcelona en  España  desde  2004,  que  evalúa  la  calidad  de  las publicaciones   científicas   mediante   el   cálculo   del Índice Compuesto de Difusión Científica (ICDS). Este índice  valora  la  presencia  de  las  revistas  en  bases  de datos    de    citas,    tanto    multidisciplinarias    como especializadas, reflejando así su alcance internacional. La última inclusión del año 2023 es ASCI (Índice de Citación  Científica  Asiática),  una  base  de  datos  que emplea  criterios  rigurosos  para  seleccionar  revistas, garantizando su calidad y relevancia académica. Estos criterios    incluyen    procesos    editoriales    sólidos, contenido   original   y   significativo,   claridad   en   el enfoque  temático,  frecuencia  regular  de  publicación, diversidad  global  de  autores,  adhesión  a  estándares éticos y una notable influencia en la citación. Con estas nuevas  indexaciones,  la  UCEVA  como  entidad  editora fortalece   su   presencia   a   nivel   internacional   y  se prepara para alcanzar objetivos más ambiciosos en su camino  hacia  la  indexación  en  plataformas  como Redalyc, SciELO y Scopus.
Diversification of cropping systems to improve national food security
Authors: Parra Londoño Sebastián
Published: February 2024

The aim of this reflection is to study and promote the diversification of cropping systems as a strategy for the improvement of food security at national level. Food security is a global challenge that nations continue to address. Agricultural systems should address this issue; however, traditional practices may not be sufficient to produce enough food for the growing population. Conversely, intensive agriculture has significantly impacted the environment by increasing the use of fertilizers and freshwater, expanding cultivation lands, and reducing biodiversity. Therefore, innovative techniques are necessary to enhance agricultural productivity while respecting planetary environmental limits that are essential for the resilience of the earth. Enhancing cropping diversity in agricultural systems could significantly increase yield and food production, optimizing land usage efficiency. This brief analysis examines the diversity of crop species in Colombia from 2006 to 2022 and its impact on agricultural production. National crop diversity has increased over time, with higher heterogeneity observed in regions such as Cundinamarca, Boyacá Antioquia, Santander, Nariño, and Valle del Cauca. Additionally, significant correlations exist between the number of crops cultivated per location and agricultural production, emphasizing the significance of diversity in food systems. Increasing crop diversity can not only improve national food security but also aid in maintaining ecosystem integrity. Further research should focus on assessing the impact of various farming system diversification, approaches on yield stability and food security at the farm level
TERRITORIES IN TRANSFORMATION: CHALLENGES AND PERSPECTIVES IN SUSTAINABLE SPACE PLANNING AND PLANNING
Authors: Kleinübing Tatiana
Published: February 2024

This article addresses the importance of territorial planning and ordering, highlighting the influence of works such as "Right to participation in urban policies: advances after 15 years of city statute", "For Another Globalization: From Single Thought to Universal Consciousness" and "Experiences in Urban Territorial Planning in Latin America: the context of Brazil”. The understanding of territory as a dynamic product of social actions highlights territorialization as intrinsic to the reorganization of territorial information and social stratification. The analysis of power relations, according to Raffestin and Saquet, reveals political-ideological conflicts in the territory. Settlements, as products of complex power relations, highlight the struggle for land and social inequalities. The rational management of natural resources, aligned with sustainability, is vital to balance environmental preservation and social equity. The main objective of the article is to analyze the resistance of the settlers, highlighting their difficulties and exploring the potential of public policies to improve their living conditions, contributing to the understanding of the dynamics of territorial planning.
ART AS A PSYCHOTHERAPEUTIC INSTRUMENT IN THE PRACTICE OF SCHOOL AND EDUCATIONAL PSYCHOLOGIST
Authors: De Oliveira Neto Ivaldo Francisco
Published: February 2024

School and Educational Psychology is today one of the fields of action within psychology and, just as there has been an evolution in the teaching-learning process in schools, there has also been a transformation in the psychologist's perspective about the student and its development. In this way, not only the theoretical conceptions have changed, but also the methodologies used, requiring from the professionals of education and psychology an adaptation in their practice, which sees the individual in an integral way. In view of this, this article sets out to present the relevance of art as a therapeutic function for the teaching-learning process, seeking as a theoretical basis the work of Nise da Silveira and the images of the unconscious. To do so, they looked for articles referring to the theme in a database such as Google Académico and Scielo, followed by a reading of the summary of the articles found to select those that addressed the proposed theme. It was concluded from this work that art as a tool for education enables processes of awareness of the being about their emotions and conflicts, as well as promotes their identification as active agent in the learning process, emphasizing the importance of an emancipating education.
Use of Modern Computational Methods and Neural Networks to Optimize Methods for LC/MS/MS Analysis of Military-Relevant Organophosphorus Compounds
Authors: Trefilík Dušan
Published: February 2024

The search for the optimal instrumental settings of conditions in chemical analysis is typically a lengthy process. This article proposes the use of neural networks for this purpose, particularly in relation to determining the optimal conditions for the analysis of substances under study using LC/MS/MS and ESI technologies, based on the knowledge of their fundamental properties, referred to as universal descriptors. The work focuses on finding such analysis conditions that maximize the precursor ion signal. The paper specifically addresses the question of whether the results obtained from one type of analyte can be used for neural-interpolated prediction of optimal conditions for similar analytes.
Analisis Deskriptif Pengetahuan Tentang Perubahan Fisik Pubertas Remaja Putri di Pondok Pesantren Alfalah Sofaniyah Kecamatan Songgom Kabupaten Brebes Tahun 2024
Authors: Utami Suci , Meikawati Pedvin Ratna , Fajriyah Laeli Fitrokhatun
Published: February 2024

Pubertas menandai peralihan dari masa kanak-kanak ke masa remaja disertai dengan rangkaian proses perkembangan fisik, kognitif, dan psikologis yang kompleks. masih banyak remaja putri yang belum mengetahui perkembangan pubertas. Kurangnya pengetahuan pubertas dapat berdampak negatif terhadap perkembangan remaja putri. Jenis penelitian ini menggunakan metode kuantitatif analisis deskriptif. Proses pengumpulan data menggunakan metode kuisioner dengan skala guttman. Dari hasil penelitian terhadap 39 sampel penelitian remaja putri di Pondok Pesantren Al Falah Sofwaniyah Jatirokeh Songgom Brebes mendapatkan hasil 25 anak (64%) remaja putri memiliki pengetahuan pubertas dengan kategori “Baik”. 11 anak (28%) memiliki pengetahuan pubertas dengan kategori “Cukup”. 3 anak (8%) memilki pengetahuan pubertas dengan kategori “Kurang”. Dengan data tersebut dapat disimpulkan Sebagian besar remaja putri pada Pondok Pesantren Al Falah Sofwaniyah Jatirokeh Songgom Brebes memiliki pengetahuan tentang pubertas dengan kategori yang baik.
PERKEMBANGAN UMKM DI DALAM MAL (Study kasus Pempek Farina di dalam Solo Grand Mal)
Authors: Al Mursyid Muhammad Hilaluddin , Admadja Efrika Dwi , Muftiningtyas Tiara
Published: February 2024

Pada zaman sekarang, pusat pembelanjaan tidak hanya untuk berbelanja, tetapi juga sebagai tempat untuk berburu kuliner. Di dalam pusat pembelanjaan Solo Grand Mal terdapat salah satu outlet kuliner yaitu Pempek Farina. Penelitian ini dilakukan dengan tujuan menganalisis perkembangan dan strategi pemasaran UMKM Pempek Farina di dalam Solo Grand Mal. Metode yang di pakai peneliti adalah metode kualitatif guna mendapatkan pemahaman yang mendalam. Subjek dari penelitian ini adalah UMKM di dalam Solo Grand Mal. Data penelitian ini diperoleh melalui mencakup wawancara dengan karyawan UMKM Pempek Farina, observasi langsung di lokasi, dan analisis kepuasan konsumen terhadap pelayanan yang ada di Pempek Farina. Peneliti menganalisis data menggunakan pendekatan analisis interaktif. Hasil penelitian ini dapat disimpulkan bahwa perkembangan dan pemasaran UMKM Pempek Farina pada awal perintisannya tahun 1994, dimulai dari menggunakan gerobak hingga kini telah mempunyai setidaknya 40 outlet di indonesia. Strategi pemasaran Pempek Farina biasanya dilakukan oleh Team Marketing dengan mengadakan promo setiap bulannya.
A Study on the Anti Urolithiatic Potential and Optimizing the solubility of Gallstones in selected plants
Authors:   Post Graduate, Department of Biochemistry, Sri Ramakrishna College of Arts and Science for Women,  Coimbatore, Tamil Nadu, India, A Vidhyashri , Prabha Dr.D.Chandra ,   Post Graduate, Department of Biochemistry, Sri Ramakrishna College of Arts and Science for Women,  Coimbatore, Tamil Nadu, India
Published: February 2024

Nature bestowed our country with an enormous wealth of medicinal plants. Medicinal plants have been known for its rich source of therapeutic agents for the prevention of various diseases. They are used from centuries due to its safety, efficacy, cultural acceptability and less side effects as compared to synthetic drugs. Alarming rise in the cholithiasis- deposition of oxalate stone in the gall bladder cases due to life style modified diets are prevailing in the current era. The anti-urolithiatic activity and the phytochemical analysis were assessed in Zingiber officinale (ginger), Macrotyloma uniflorum (horsegram), Phyllanthus emblica (amla) and Musa sp (banana stem) with four different solvents namely distilled water, ethanol, chloroform, hexane to study the anti-urolithiatic activity. We observed that Zingiber officinale (ginger), Phyllanthus emblica(amla), Macrotyloma uniflorum (Horsegram) and Musasp (banana stem) exhibits anti urolithiatic activity. Keywords: Medicinal plants, Gall stones, Anti-urolithiatic activity, Phytochemical analysis,
Technical Project Status Display Information System
Authors:   Undergraduate Student, Computer Science Engineering, Vidyavardhaka College of Engineering, D Preetham , P Aishwarya ,   Undergraduate Student, Computer Science Engineering, Vidyavardhaka College of Engineering
Published: February 2024

This paper presents the development of a one-page web application aimed at providing stakeholders with a succinct overview of ongoing projects and recently completed ones within a timeframe. Utilizing HTML, CSS, and JavaScript, along with contemporary web technologies, the application delivers an interface that is both user-friendly and informative[1]. By synchronizing data in real-time with project management tools and incorporating data visualization techniques, the application facilitates efficient access to and interpretation of project-related information for stakeholders. Emphasizing the importance of such a tool in fostering transparency, enhancing communication, and supporting decision-making in project management contexts, this paper also delves into technical implementation aspects, such as integration with project management APIs, design, and considerations for responsive design. This work contributes to advancing web-based solutions for project management, offering valuable insights into the creation of streamlined and accessible tools tailored to stakeholder requirements[2]. Key Words: stakeholder, project management, data visualization, decision-making, streamlined.
A Comparative Study of Vo2 Max and Different Playing Positions of Mysore University Inter- Collegiate Male Kabaddi Players
Authors:   St. Joseph’s First Grade College, Jaylakshmipuram, Mysore-570012, K.S Harish Kumar
Published: February 2024

Games and sports have been part of human life almost since the time immemorial beit a necessity for his survival i.e.hunting for food shelter and safety from wild animal or other enemies ,or as a pursuit of pleasure.The games and sports have been indispensable to mankind, and have become mode of come part of culture. The gamesand sports are e great unifying force and have tremendous effect on the national and international integration. Through the origin of sports is lost in antiquity, it is quite certain that physical activity has been a part of the life of even primitive men. For himit might have been a basic necessity of life,more than fun and diversion, for his survival depended on it. Hunting, fishing, hurling missiles were activities on whichhis survival depended.Gradually along with the process of evolution, such activities become more of play and become part of the culture of the tribes. People use sports and games as a mode of transmitting the cultural heritage of their tribes. Games sports and physical activities persisted despite the rise and fall of ancient civilizations and become strongly embedded in the history of civilizations as a culture heritage, which was passed on from one generation to another. Today, games and sports have emerged as universal cultural phenomena. Sports and games propagate the feelings of nationalism and help in creating a new generation of individuals with the feelings that the difference basedon caste, community and religion have no meaning and faith in love and peace, in purity, in the feeling of goodwill and brotherhood serves to a greater extent towards humanity. Sports and games provide a common platform wheresportsperson for different regions, professing different religions and faiths, speaking different languages, havingdifferent customs and traditions interact with each other in harmonious and emerge as a homogenous group. Such type of thinking insight and mental approach can play positive role in nation integration. Sports and games help in creating such understanding and can play decisive and pivotal role in bringing about national integration.
Disorientasi Seksual dalam Perspektif Etis Teologis: Diskursus Pendidikan Kristen Bagi Remaja
Authors: Arifianto Yonatan Alex
Published: February 2024

The Phenomena that occur in society related to sexual disorientation make headlines in national news portals as public consumption. It can be seen from the unrighteousness towards sexual orientation deviation. What is the role of the church and Christian family towards sexual orientation deviation. The church can provide Christian education to be taught to teenagers who are full of self-discovery and high curiosity related to sexuality. Using a descriptive qualitative method with a literature study approach, the Bible becomes the primary source, it can be concluded that sexual disorientation in a theological ethical perspective must have the correct paradigm and understanding of the correct sexual orientation. Therefore, sexual disorientation education is needed for all sides of life related to physical, spiritual and mental and psychological. Of course, Christian education that provides correct understanding related to sexual disorientation for adolescents. Abstrak:Fenomena yang terjadi dalam masyarakat terkait disorientasi seksual  menjadi berita utama dalam portal berita nasional sebagai konsumsi masyarakat. Hal itu dapat dilihat dari ketidakbenaran terhadap penyimpangan orientasi seksual. Bagaimana peran gereja dan keluarga Kristen terhadap penyimpangan orientasi seksual. Gereja dapat memberikan pendidikan Kristen untuk diajarkan kepada remaja yang sarat mencari jati diri dan rasa keingintahuan yang tinggi terkait seksualitas. Menggunakan metode kualitatif deskritif dengan pendekatan studi literature,  Alkitab menjadi sumber primer, maka dapat disimpulkan bahwa disorientasi seksual dalam perspektif etis teologis harus memiliki paradigma dan pemahaman yang benar terkait orientasi seksual yang benar. Oleh sebab itu pendidikan disorientasi seksual diperlukan untuk semua sisi kehidupan terkait jasmani, rohani maupun mental dan psikologis. Tentunya pendidikan Kristen yang memberikan pemahaman benar terkait disorientasi seksual  bagi remaja. Kata Kunci: Disorientasi Seksual; Etis Teologis; Diskursus; Pendidikan Kristen; Remaja
MENDIALOGKAN INJIL DAN BUDAYA: “Hospitalitas Kristen dalam Tradisi Sorongan Sepu’ di Toraja”
Authors: Papalagi Yogaste La'te , Assi Asrianto Asril , Bawan Yustus Abner
Published: February 2024

This article discusses the value of Christian hospitality in the Sorongan Sepu' tradition in Toraja. Sorongan Sepu' is a practice that involves welcoming and serving guests by handing them a small bag or sepu' containing food at the Rambu Solo' and Rambu Tuka' ceremonies. The research method used is a qualitative ethnographic model approach with data collection techniques through observation, interviews and literature study. Research findings show that the values of Christian hospitality in the Sorongan Sepu' tradition include friendliness, openness, solidarity, kinship, tolerance and respect. These values are aspects of inclusive life amidst the reality of the multicultural and pluralistic Toraja society.Artikel ini membahas tentang nilai hospitalitas Kristen dalam tradisi Sorongan Sepu’ di Toraja. Sorongan Sepu’ merupakan praktik yang melibatkan penyambutan dan pelayanan terhadap tamu dengan menyodorkan tas kecil atau sepu’ yang berisi pangngan pada upacara rambu solo’ maupun rambu tuka’. Metode penelitian yang digunakan adalah pendekatan kualitatif model etnografi dengan teknik pengumpulan data melalui observasi, wancara dan studi literatur. Temuan penelitian menunjukkan bahwa nilai hospitalitas Kristen dalam tradisi Sorongan Sepu’ diantaranya keramahan, keterbukaan, solidaritas, kekerabatan, toleransi dan penghargaan. Nilai tersebut meruakan aspek-aspek hidup yang inklusif di tengah kenyataan masyarakat Toraja yang multikultur dan majemuk. Kata kunci: Medialogue; Christian Hospitality, Sepu's Encouragement
The importance of the results of the examination of cartridge cases and the negative factors to be taken into account in the identification
Authors:   Grigol Robakidze University, Dzindzibadze Giorgi
Published: February 2024

The paper focuses on cartridge cases, fired from handguns, as objects of forensic-ballistics research, the cartridge cases, in turn, is an integral component of the cartridges. Cartridges for modern handguns can be divided as follows: Cartridges for smoothbore weapons, cartridges for rifled guns and cartridges of nominal caliber. Nowadays, unitary cartridges are mainly used, their cases and primers are made in different enterprises, with different metals, which somewhat complicates the process of identifying cartridge cases, whereas individual marks of weapon parts and mechanisms on different metals are reflected more or less differently. The purpose of the article is to show the process of comparing cartridge cases fired from firearms with each other, determining the value of identification results and discuss the problems, that arise during identification. It's all quite a complicated process. When comparing cartridge cases, the question of whether or not the general marks coincide must first be resolved. In case of coincidence of general signs, the examination will be continued according to private marks and if the general marks do not match, the examination in this regard will be terminated. As a result of the examination, the expert must draw a conclusion about the coincidence, not-coincidence or inability to identify. The expert conclusion is categorical and it is provided for during the investigation and the court. The identification process is difficult, as the process of comparison it is necessary to takes into account the long exploitation of the weapon, reflected in the details, which generate marks; Various metals used in the manufacture of the cartridge cases; Additional studies before and after the shot on the cartridge cases, which are not of weapons, from which the cartridge cases was fired; The shape and size of the projectile placed in the cartridge. Consequently, conducting such an research is quite difficult, requires time and appropriate qualifications. Key words: cartridge case, identification, general marks, individual marks, ammunition, projectile.
On the use of smart contracts to cope with Arrow’s Information Paradox on trade secrets exchange: method and prototype
Authors: Schüler Erik , Busnello Felipe Octaviano Delgado , Cabral Anderson Ricardo Yanzer , Da Silva Roger Sá
Published: February 2024

The state of the art contains systems for the transfer of intangible assets protected by intellectual property rights, consolidated by legal monopolies, be them attributive systems (such as patents and industrial designs) or reliant on automatic protection (such as copyright and neighboring rights). Some of these systems, or their respective methods, are described in the scientific literature. Of this set, some methods employ blockchain technology and a smaller subset also employs smart contracts technology, despite both technologies being mutually independent. Although trade secrets also constitute monopolies, computerized solutions or cryptographic environments used for other types of goods protected by other forms of intellectual property cannot be transferred to these assets, due to their sui generis nature, lacking of monopoly regardless of its non-disclosure. The need for maintenance of secrecy is due to Arrow Information Paradox, the phenomenon by which the disclosure of the secret constitutes by itself its transference. This phenomenon impairs the potential for transference of industrial secrets and prevents the adoption of the existing systems applicable to other types of intangible assets. Through this work a method for transferring industrial secrets is presented, using smart contracts embedded on a blockchain, for solving two of the three component elements of the Paradox, namely capability and reliability, and presupposes the third, relevance. The method is also validated through the development of a prototype, based on Ethereum blockchain.
Empreendedorismo, inovação e propriedade intelectual Entre os universitários da cidade de Manaus
Authors: De Araújo Andrea Campos Guerra , De Oliveira Júnior Manoel Carlos
Published: February 2024

A pesquisa em tela tem por objetivo identificar e analisar o nível de conhecimento de universitários acerca da temática empreendedorismo, inovação e propriedade intelectual. Tem-se como recorte a cidade de Manaus, e estudantes de nível superior. Para obtenção dos dados, realizou-se pesquisa bibliográfica, com palavras-chave específicas, em periódicos detalhados na seção metodologia. Além disso, foi aplicado um questionário eletrônico, elaborado com base no instrumento utilizado pela Student Attitudes Towards Intelectual Property, realizado pela National Union of Students (NUS), junto ao público-alvo da pesquisa, caracterizado por estudantes universitários, em faculdades públicas e privadas, da cidade de Manaus. Os resultados mostram um conhecimento parcial sobre as temáticas abordadas, fazendo-se necessário, por isso, a adoção de estratégias de divulgação dos três elementos abordados junto ao público-alvo da presente pesquisa.
Rationalization of the operation process of intrusion and hold-up alarm systems
Authors: Krzykowska-Piotrowska Karolina , Rosiński Adam , Paś Jacek
Published: February 2024

Intrusion and hold-up alarm systems (I&HAS) are part of electronic security systems. They are now installed in many facilities, including those classified as critical infrastructure. The variety of available alarm control panels and their configurations means that I&HAS are installed with the use of alarm control panels with various functional and diagnostic capabilities. In the process of operation of intrusion and hold-up alarm systems, maintenance actions are most often used when no damage has occurred. This is referred to as preventive maintenance. These activities are aimed at carrying out preventive maintenance that will reduce the likelihood of damage or deterioration of the system. An extension and also an evolution of preventive maintenance activities is the development of the eMaintenance concept. By implementing modern solutions in diagnosing intrusion and hold-up alarm systems and using advanced IT applications, it is possible to monitor them and manage the operational process in real-time with the possibility of observing the degradation of the I&HAS. This makes it possible to take action to prevent the transition to a state of partial fitness or unfitness. As a result of the analysis of the operation process of the intrusion and hold-up alarm systems, taking into account diagnostic information, a graph of relations occurring in the system was developed. Then, dependencies were determined to calculate the probabilities of the I&HAS being in a state of full ability, states of periodic service, states of partial ability, and a state of unfitness. The issues of modelling the operation process of intrusion and hold-up alarm systems presented by the authors make it possible to rationalize the intensity of periodic inspections. The result is an increase in the value of the readiness index of I&HAS, which is particularly important in the case of securing critical infrastructure facilities.
PREVALENCE OF THE USE OF CORTICOIDS FOR THERAPEUTIC PURPOSES IN ALLERGIC RHINITIS AND RHINOSINUSITIS AND THEIR SIDE EFFECTS AMONG UNIVERSITY STUDENTS IN THE HEALTH AREAS OF SANTA CATARINA AND RIO GRANDE DO SUL
Authors: Fuzinatto Suellen Balbinoti , Mognon Nicole Moreira , Zirolometa Eduarda Cavalli , Dos Santos Lucas Bottesini , Roque Kaynan Matos , Macrhy Vanessa , Fincatto Yan , Zancanaro Vilmair
Published: February 2024

Allergic rhinitis is defined as inflammation of the nasal mucosa, induced by exposure to allergens. Rhinosinusitis is defined as an inflammation of the nasal mucosa and sinuses. Corticosteroids are the most prescribed medications to treat rhinosinusitis and allergic rhinitis, as they act on the inflammatory components of the disease, reducing the infiltration of inflammatory cells on the surface of the nasal mucosa. The general objective is to understand the effects of the use of corticosteroids on rhinitis and rhinosinusitis, observing the incidence of use of these medications among university students in the health areas of the states of Santa Catarina and Rio Grande do Sul, considering the consequences caused by excessive use. The methodology consists of quantitative data analysis aiming to collect information in an online questionnaire, analyzed statistically and carefully. The results reveal that 79.4% of the participants in the questionnaire already had rhinitis or rhinosinusitis, of which 63.2% used corticosteroids in different ways, the most commonly used orally. Furthermore, the main side effects presented were drowsiness, irritation and burning, in addition to body swelling. It is concluded that the use of corticosteroids must be done with caution and the patient's viability given the possible adverse effects present.
Nurture and play for foster families with young children: Foster-parents’ reflections on attachment focused group intervention
Authors: Tuomi Kirsi , Ala-Ruona Esa
Published: February 2024

An insecure attachment history puts foster children at risk for many kinds of difficulties, which may include psychopathology. Nurture and Play (NaP) for foster families–intervention for children aged one to five years of age aims to help the new attachment relationship between foster parents and their young children develop in a secure direction. The aim of this study is to gain deeper understanding on how foster parents use their mentalization skills to reflect the different meanings of the NaP for foster families-intervention. A stimulated recall method was chosen to correspond to these research targets. It was revealed that parents’ reflections were evidently focused on the child, the importance of safety and the meaning of change during the process. Emotional qualities concerning both the child and the adult were also emphasised. The foster parents were able to utilise their reflections within a wider context of place, relationships, and time. The results of the study and the core concepts of attachment theory are strongly related to each other. Furthermore, the study and its outcomes offer suggested priorities and suggestions for future research.
Screening and prevention of ovarian cancer
Authors: Sideris Michail , Menon Usha , Manchanda Ranjit
Published: February 2024

Ovarian cancer remains the most lethal gynaecological malignancy with 314 000 cases and 207 000 deaths annually worldwide. Ovarian cancer cases and deaths are predicted to increase in Australia by 42% and 55% respectively by 2040.

Earlier detection and significant downstaging of ovarian cancer have been demonstrated with multimodal screening in the largest randomised controlled trial of ovarian cancer screening in women at average population risk. However, none of the randomised trials have demonstrated a mortality benefit. Therefore, ovarian cancer screening is not currently recommended in women at average population risk. More frequent surveillance for ovarian cancer every three to four months in women at high risk has shown good performance characteristics and significant downstaging, but there is no available information on a survival benefit.

Population testing offers an emerging novel strategy to identify women at high risk who can benefit from ovarian cancer prevention. Novel multicancer early detection biomarker, longitudinal multiple marker strategies, and new biomarkers are being investigated and evaluated for ovarian cancer screening.

Risk‐reducing salpingo‐oophorectomy (RRSO) decreases ovarian cancer incidence and mortality and is recommended for women at over a 4–5% lifetime risk of ovarian cancer. Pre‐menopausal women without contraindications to hormone replacement therapy (HRT) undergoing RRSO should be offered HRT until 51 years of age to minimise the detrimental consequences of premature menopause.

Currently risk‐reducing early salpingectomy and delayed oophorectomy (RRESDO) should only be offered to women at increased risk of ovarian cancer within the context of a research trial. Pre‐menopausal early salpingectomy is associated with fewer menopausal symptoms and better sexual function than bilateral salpingo‐oophorectomy.

A Sectioning and Extensively Examining the Fimbria (SEE‐FIM) protocol should be used for histopathological assessment in women at high risk of ovarian cancer who are undergoing surgical prevention.

Opportunistic salpingectomy may be offered at routine gynaecological surgery to all women who have completed their family. Long term prospective opportunistic salpingectomy studies are needed to determine the effect size of ovarian cancer risk reduction and the impact on menopause.
Uma abordagem para gestão de cenários no ensino de Segurança de Sistemas de Informação
Authors: Ferreira Rafael Vinícius Barros , Freitas Bruno P. T. , Lazarin Nilson M.
Published: February 2024

A formação de profissionais capacitados para atuarem na área de Segurança de Sistemas de Informação (SSI) é de suma importância para atender a necessidade das organizações que necessitam de proteção de dados e sistemas. A ênfase somente no conteúdo teórico das disciplinas de SSI e a falta de uma preparação adequada para lidar com segurança, são alguns dos motivos apontados por egressos de cursos superiores, que impactam na não implementação de técnicas de prevenção de ataques cibernéticos em suas aplicações. Este trabalho propõe uma abordagem para gestão de cenários de ataque e defesa cibernética para serem utilizados em aulas práticas de SSI, através da definição de ambientes de rede contendo ativos das camadas 2, 3 e 7 do modelo ISO/OSI.
Impacto da otimização de funções hash no desempenho do algoritmo de assinatura digital pós-quântica CRYSTALS-Dilithium
Authors: Meneses Rodrigo Duarte de , Henriques Marco Aurélio Amaral
Published: February 2024

O algoritmo de assinatura digital CRYSTALS-Dilithium é um dos algoritmos pós-quânticos recentemente padronizados pelo NIST. A partir de estudos na literatura indicando um overhead computacional associado às funções hash utilizadas no algoritmo, otimizamos sua implementação com a adoção da função hash TurboSHAKE. Tal otimização conferiu maior velocidade para o Dilithium em todos os níveis de segurança, sem alterar o uso de memória RAM.
Análise dos Mecanismos de Geração e Armazenamento de Chaves em Carteiras de Criptomoedas
Authors: Souza Anderson O. de , Silva José Vitor H. da , Lazarin Nilson M.
Published: February 2024

Este artigo descreve uma análise de segurança de uma lista de softwares conhecidos como carteiras de cripto ativos, focando na geração e armazenamento de chaves. Esta análise visa informar futuros usuários em relação ao nível de segurança implementado, detalhes técnicos específicos de seus componentes internos, bem como métodos de restauração e backup de chaves. Foram selecionadas seis carteiras de acordo com a possibilidade de acesso ao código-fonte e popularidade, e em seguida avaliadas de acordo com um conjunto de oito parâmetros relevantes no quesito segurança.
DL-SAFE: Proteção Baseada em Aprendizado Profundo para Detecção de Botnets na Borda
Authors: Guimarães Lucas Chagas de Brito , Couto Rodrigo de Souza
Published: February 2024

Dispositivos de Internet das Coisas (IoT) são fundamentais para setores como casas, cidades e redes inteligentes. Entretanto, a existência de bilhões de dispositivos com poder computacional limitado os torna alvos para botnets. Este artigo propõe DL-SAFE, uma ferramenta para classificação de tráfego em ambientes de borda usando Open Argus e Pytorch. A ferramenta também permite a avaliação de arquiteturas de redes neurais usando 3 tipos de camadas. Os resultados demonstram a eficácia da ferramenta, obtendo precisão e sensibilidade superior a 99% para diversos modelos. Os teste de vazão apontam que o desempenho varia de acordo com a arquitetura, com metade dos modelos avaliados processando mais de 1000 fluxos por segundo.
INOVA ID RS: Desenvolvimento de um Sistema de Gestão de Identidade Federada Aderente ao Ecossistema de Inovação do Rio Grande do Sul
Authors: Lira Rodrigo Cesar , Ribeiro Rui de Quadros , Sousa Fiterlinge , Wangham Michelle Silva
Published: February 2024

O governo do estado do Rio Grande do Sul criou o programa INOVA RS com o propósito de fomentar a colaboração entre diversos atores do ecossistema de inovação gaúcho, visando impulsionar o desenvolvimento econômico e social regional. Como uma iniciativa decorrente desse programa, surgiu o projeto INOVA ID RS, que busca a construção de uma identidade digital para o ecossistema de inovação, bem como a implementação de uma federação destinada ao compartilhamento seguro de serviços digitais. Este trabalho apresenta os resultados preliminares da concepção e desenvolvimento da Federação INOVA ID RS, que está baseada nos padrões SAML e OpenId Connect.
Integração do passkeys em Provedores de Identidade Shibboleth
Authors: Rosa Andrey Adriano da , Mello Emerson Ribeiro de
Published: February 2024

User authentication based on passwords is susceptible to various attacks and imposes a significant cognitive load on users. Multi-factor authentication seeks to minimize the effectiveness of certain remote attacks, but it often penalizes usability. Passkeys, a term coined based on recent standards from the FIDO Alliance and W3C, emerge as a robust alternative with a focus on usability for remote user authentication on the web. This work presents a solution for integrating passkeys into Shibboleth Identity Providers, enabling their use both as a second factor and as the first authentication factor.