bluuebunny/crossref_metadata_2025 huggingface dataset:
Vibrio Cholera 22: Isolation And Molecular Detection of Cholera Toxin (CTX) in Some Iraqi Governorates
Authors:   Department of Microbiology, Veterinary Medicine College, University of Baghdad, Iraq, Aldoori Atheer , Samawi Farah ,   Biotechnology Research Center, Al-Nahrain University, Baghdad, Iraq, noori Anas ,   Biotechnology Research Center, Al-Nahrain University, Baghdad, Iraq, Ahmed Kifah ,   Epidemiological Unit, Central public health laboratory, Ministry of Health
Published: August 2024

Vibrio cholerae is a major etiology of diarrhea in humans worldwide. In this study, we isolated and identified V. cholerae from the human stool of suspected cases admitted in different hospitals of Iraqi governerate. A total of (180) suspected patient stool samples infected with Vibreo cholera (V. cholera) ,110 sample were positive and showed growth of yellow colored colonies when cultured on Thiosulfate citrate bile salt agar(TCBS ). The isolates were Gram-negative, curved shaped, and motile. Biochemically, they were found positive for indole and Methyl Red tests and negative for Voges– Proskauer test when we used API 20 test. Ninty of the isolates were ogawa when made serotyping test. Antibiotic sensitivity test revealed these isolates as highly sensitive to chloramphenicol, tetracycline m Ampicillinm , and Erythromycin while resistant to TR , and oxacillin. After the routine culture of samples for isolation and identification of V. cholerae isolates, PCR was performed for molecular detection of V. cholerae isolates based on 16S ribosomal RNA and ompW genes. Toxigenicity was detected by CTX toxin genes. Out of the 110 positive samples, only 50 isolates were positive for CTX gene, using genus-specific primers.
Polycystic Ovary Syndrome under TNF and TAC Regulation
Authors:   University of Babylon, College of Science for Women, Biology Department, Iraq, Al-Musawi Hawraa , AL-hindi Zeana ,   University of Babylon, College of Science for Women, Biology Department, Iraq, Al- mamoori Noor ,   University of Babylon, College of Science for Women, Biology Department, Iraq, Shareef Hasanain ,   University of Babylon, College of Science for Women, Biology Department, Iraq,   Al-Mustaqbal University, College of Science, Department of Medical Biotechnology, Ibraheam Israa ,   University of Babylon, College of Science for Women, Biology Department, Iraq, Kadhim Wurood ,   University of Babylon, College of Science for Women, Biology Department, Iraq
Published: August 2024

Background: Polycystic Ovary Syndrome (PCOS) is a hormonal syndrome. One of an important disorder in women under physiological and immunological regulation. Affected by many factors and can diagnosis by many serological and immunological markers. Aim of study: Goal of present study target on tumor necrosis factor (TNF) and total antioxidant capacity (TAC) investigation. Methods: Current investigation involved 80 women (patients and control) with different ages from JANUARY 2022 to MARCH 2023 after recording information about patients. The cupric ion reduction antioxidant capacity (CUPRAC) method has been used to estimate TAC. ELISA test performed to evaluate TNF. Results: The highest percentage of disease was found in the age group [19-22]. It was the highest rate of 58%, followed by the age group [23-26] the lowest incidence rate in the age group [27-30] was 5%. According to location of patients in cities, varied between four cities included (Babylon, Karbala, Najaf and Baghdad) with a highest frequent showed in Babylon as (60%). Physiological study showed there are non-significant different between blood groups and PCOS under (P≤0.05), although varied the percentage in patients in four types (A+, B+, AB+ and O+) with highest percent in A+ about (38%). On other manner when measured total antioxidant capacity (TAC) also showed non-significant different between patients and control according to age group with a highest concentration in age group (19-22 y) in patients and control (3.7033± 0.8835 μm/l) (3.106± 0.427 μm/l) respectively. Immunological study, TNF concentration showed statistically significant difference (P≤0.05) in all age group compared to control with a highest level in (27-30y) as (170.207±3.68 pg/ml) for patients and (45.479±1.247 pg/ml) to control. Conclusion: The current study pointed about the correlation subject between TNF and TAC, results find there is an inverse correlation between them in patients’ group with present revers relationship in control group, that ensure an important of immune regulation. Those achieve the aim of our study.
Role of CD200 and CD43 in Diagnosis and Prognosis of CLL and NHL Patients
Authors:   University of Babylon, Collage of Medicine, Pathology Department, Al Sharifi Liqaa , Abdul Ridha Haider ,   University of Babylon, Collage of Medicine, Pathology Department, Rashid Ahmed ,   University of Babylon, Collage of Medicine, Pathology Department, Muhsin Sinan ,   University of Babylon, Collage of Medicine, Pathology Department, Jaafer Teeb ,   University of Babylon, Collage of Medicine, Pathology Department
Published: August 2024

Background: Chronic lymphoproliferative disorder (LPD), is a malignant disease of lymphocytes in the blood and lymphatic tissue. Chronic lymphocytic leukaemia, it is the commonest type of chronic lymphoproliferative disorder. Scoring by immunophenotyping is used to differentiate B-cell chronic lymphocytic leukemia from other B-Non-Hodgkin lymphomas. CD200 (OX2) is a glycoprotein of membrane, it is related to type I superfamily of immunoglobulin . CD43 (Sialophorin) is a sialoglycoprotein that is present on the surface of T lymphocytes, some B lymphocytes, granulocytes and monocytes, that play important role for immune function and also play a role as physiologic ligand-receptor complex involved in T- cell activation. Aim of study-Evaluate the role of CD200 and CD43 positive expression and co-expression in diagnosis and prognosis of CLL and NHL. Subjects and Methods: This cross sectional study on one hundred forty five patients with chronic lymphoprliferative disorders who were attending Baghdad teaching hospital at medical city from beginning of January 2020 to end of December 2020, patients divided in to two groups; chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) patients At diagnosis, there was assessment of CD200 and CD43. Clinical and laboratory data were done including staging by modified Rai, and Ann arbor staging system ( for CLL and NHL respectively), then follow up for about 6-12. Results: There is significant statistical correlation between CD 200 and CD 43 and often co-expression of both in differentiation between CLL and NHL (p value < 0.001). Almost all patients of CD 200 positive expression show moderate to bright pattern of expression in CLL in apposite to NHL patients, who showed dim to moderate pattern of expression, while the great majority of CD43 expression was dim to moderate pattern in both CLL and NHL patients.In CLL patients there was no significant correlation between prognostic markers (age, Hb, platelets count, lymphocytes count and CD 38 expression) and CD200, CD 43. For NHL patients, all markers show no significant correlation except that CD 43 show significant correlation with expression of CD 38. Conclusion: CD200, CD43 and often co-expression of both have a significant value in diagnosis and differentiation of CLL from B- NHLs.
METAFORA KONSEPTUAL EMOSI MARAH: STUDI KASUS MASYARAKAT SUKU JAWA DI PROVINSI LAMPUNG
Authors: Pangestuti Dina Agil
Published: August 2024

Metafora konseptual emosi marah telah dikategorisasikan oleh Kövecses (2003) dalam beberapa bentuk metafora seperti salah satu contoh ANGER IS THE HOT OF A FLUID IN A CONTAINER. Tujuan dari penelitian ini adalah melihat metafora konseptual emosi marah pada penutur Bahasa Indonesia beretnis Jawa di Provinsi Lampung, dengan menerapkan konseptual metafora yang telah dikonsepkan Kövecses (2003). Penelitian ini merupakan studi kasus dengan melibatkan empat partisipan perempuan. Pengambilan data dilakukan dengan mewawancarai partisipan yang sesuai dengan kriteria. Hasil penelitian ini mendukung temuan Kövecses. Namun, peneliti menemukan keunikan metafora konseptual emosi marah yang belum dirumuskan oleh penelitian sebelumnya yang dipahami sebagai objek berupa benda padat yang menyebabkan rasa tidak nyaman di dalam dada. Kata Kunci: Metafora konseptual, emosi marah, perempuan, Jawa
Simbolisasi dan Nilai Moral dalam “Ramayana”
Authors: Malik Muhammad Ardiansah Maulana , Wirajaya Asep Yudha , Wirajaya Asep Yudha
Published: August 2024

Studi ini bertujuan untuk menggali dan menganalisis simbolisme serta nilai moral yang terkandung dalam karya sastra Jawa Kuno, "Ramayana". Dengan menggunakan pendekatan hermeneutika, penelitian ini menyelidiki berbagai elemen simbolik yang tersembunyi dalam narasi dan bagaimana elemen-elemen ini berkontribusi pada pembentukan nilai moral dan budaya masyarakat Jawa kuno. Penelitian ini juga membahas perbandingan antara versi Jawa Kuno dan versi lain dari epos Ramayana, untuk menyoroti keunikan interpretasi lokal dan pengaruhnya terhadap nilai-nilai sosial dan budaya. Hasil penelitian menunjukkan bahwa Ramayana versi Jawa tidak hanya merupakan karya sastra yang menghibur, tetapi juga sarana pendidikan moral dan spiritual yang mencerminkan kebijaksanaan serta filosofi hidup masyarakat Jawa kuno. Penelitian ini memberikan wawasan baru tentang pentingnya simbol dan moral dalam sastra klasik Jawa, serta kontribusinya terhadap pembentukan identitas budaya dan nilai-nilai masyarakat. Kata kunci: Simbolisasi, Nilai Moral, Ramayana
KECEMASAN TOKOH NISKALA DALAM FILM KU KIRA KAU RUMAH KAJIAN PSIKOANALISIS
Authors: Maghfiroh Erisa Faridatul , Darmadi Renalita Adesyah Putri , Apriliany Yeppi , Nugroho Abdillah
Published: August 2024

Tujuan penelitian ini untuk mendeskripsikan karakteristik dan   kecemasan tokoh Niskala dalam film Ku Kira Kau Rumah menggunakan kajian psikoanalisis. Metode penelitian kualitatif deskriptif digunakan dalam penelitian ini. Menggunakan dua teknik penelitian. Teknik studi kepustakaan yang dilakukan dengan mengintegrasikan referensi yang memiliki fokus sebagai landasan teori yang digunakan. Teori yang digunakan berupa dari seorang pakar bernama Sigmund Freud. Psikoanalisis berangkat dari sebuah ilmu guna menelisik tujuan sebuah sikap psikologis dari manusia. Teknik observasi dengan menganalisis film Kukira Kau Rumah yang dilakukan secara berulang-ulang yang diiringi dengan group discussion guna mendapatkan berbagai perspektif berbagai sudut. Dari data yang telah dikaji terhimpun sepuluh data yang dimana dapat disimpulkan, karakteristik tokoh  Niskala yaitu, bipolar, ramah, introvert, dan koleris. Para pemeran pendukung turut menonjolkan tokoh Niskala dengan sifat dan sisi kecemasan yang dimilikinya. Atau dapat dikatakan sutradara mengemas film dengan apik hingga rasa sampai kepada pononton atau penikmat film. Kecemasan tokoh Niskala dalam film tersebut terdapat, kecemasan realistik, kecemasan neurotik, dan kecemasan moral.
THE EFFECT OF PjBL-STEM LEARNING MODEL ON STUDENTS’ COGNITIVE SKILL IN MATTER SUBSTANCES AND THEIR CHANGES SUBJECT
Authors: G Mufidah , Putri Rahmah Evita , Oktavia Rani , Azzahra Firda
Published: August 2024

The background of this research was the results of the researcher's observations on 8th grade students of SMPN 14 Padang. Based on the results of observations, information was obtained that teachers had previously implemented the PjBL learning model but never had implemented the STEM approach, and teachers had never combined the learning model with the STEM approach. The purpose this research was to examine the effect of the PjBL-STEM learning model on students' cognitive skill regarding substances and their changes subject. The type of research used was Quasi Experimental, design, using a Posttest Control Group Design. This research used two classes, there were experimental and the control class. The experimental class uses the PjBL-STEM learning model, while the control class used a conventional approach learning model. Sampling in this study was carried out using a purposive sampling technique, based on almost the similliary average daily test scores. The instrument of this research were multiple choice test with 20 questions. The results of data analysis show that the cognitive skill of students in the experimental class are higher than those in the control class. The used of the PjBL-STEM learning model makes a good difference in students' cognitive abilities. The results of hypothesis testing based on posttest data obtained from the two sample classes showed that, H0 was rejected and H1 was accepted, so it can be interpreted that there is a difference in the average cognitive abilities of students in the experimental class and the control class. There is an effect of the application of the PjBL-STEM learning model on the students’ cognitive skill on substance material and its changes subject.
Equations in one variable over two-step nilpotent groups and chains of centralizers
Authors: Buchinskiy I.M.
Published: August 2024

In the article we prove the equivalence of the concepts of equationally Noetherianity of a torsion-free two-step nilpotent group and the existence in it of an infinite chain of strictly decreasing centralizers and present the idea of a two-way connection between equationally Noetherian partially commutative two-step nilpotent groups and equationally Noetherian graphs with loops.
Framing Analysis of Israel-Palestine Conflict News on Online Media Detik.com and Republika.co.id
Authors: Hanief Lalita , Ainani Muhammad
Published: August 2024

The conflict between Israel and Palestine has become a humanitarian tragedy and is in the spotlight of the world's mass media. This research seeks to determine the framing of the coverage of the Israeli-Palestinian conflict based on Zhongdang Pan and Gerald M. Kosicki's analysis model. Two leading online media, detik.com and republika.co.id, were selected as research objects because they have a long history, different audiences, and contrasting approaches to reporting, which reflect their views and handling of the Israeli-Palestinian conflict. It is a qualitative study; data was collected through observation, documentation, and literature study. The analysis results found that detik.com and republika.co.id syntactically present the facts clearly; the script fulfills the 5W + 1H elements with credible source quotes. The thematic structure of detik.com emphasizes the number of victims due to Israeli attacks on Palestine. The rhetorical structure of detik.com contains idioms and displays photos relevant to the news content. The thematic structure of republika.co.id emphasizes the form of Israeli attacks on the Jabalia Refugee Camp. The rhetorical structure contains idioms and photos relevant to the news content. Detik.com frames the news by using the figurative word "bak neraka dunia” (like hell on earth) so that it seems dramatized in its point of view, while republika.co.id is more straightforward in writing sentences and reporting.
Framing News of Hamas Attacks: Automated Journalism Practices at NewsGPT.ai
Authors: Suprayitno Dede , Wardani Ayu , Yuliandri Putrawan
Published: August 2024

The Hamas militant group's attack on the population of Israel was recorded in the Model Automated Journalism platform, NewsGPT.ai. The platform, led by CEO Alan Levy, claims to be the world's first AI-generated news. This research aimed to reveal the news framework presented by the NewsGPT.ai platform regarding the Hamas attack on Israel on October 7, 2023. Specifically, it investigated the way NewsGPT.ai positions Palestine and Israel in the news coverage. It used a qualitative approach with Robert N. Entman's framing theory. Entman's main concepts include defining problems, diagnosing causes, making moral judgments, and treatment recommendations. Within 10 selected news, an information bias regarding the Hamas attack on Israel on October 7, 2023, was found. The news produced by NewsGPT.ai is subjective, in terms of the theme, reporting angle, and diction for the news object. Hamas tends to be associated with terrorists. The word terrorist is dominant in the text, referring to the actions of Hamas. Some terms that typically appear are acts of terrorism, terrorist attacks, fighting terrorism, and terrorist organizations. NewsGPT.ai presents information bias regarding this issue with a dominant emphasis on strengthening support for Israel. The use of AI in journalism, especially NewsGPT.ai, still shows bias towards certain groups.
Beyond digital international tourism communication network for tourism quality improvement
Authors: Nirwana Maya Diah , Maksum Ali , Avicenna Fitria , Fidarijanthi Ratu Aulia
Published: August 2024

Collaboration is essential for any tourism location to be successful in solving difficulties. The study aims to explore the motivations behind the collaboration of Malang Raya (Greater Malang), Indonesia. We focus on the prerequisites organizations must meet to participate in collaborative international tourism initiatives. We applied the qualitative technique. There are 30 informants from public relations, governments, scholars, media, international tourists, travel agents, communities, and tourism associations. We conducted semi-structured interviews and observations. The results demonstrate that the digital network of international tourism communication collaboration in Malang Raya is not optimal yet. The efforts made by the Destination Management Organization (DMO) in Malang Raya in the future will become a ‘diamond’ for improving the quality of tourism. International tourism will be brilliant, valuable, and of good quality. The international tourism communication collaboration digital network implemented: a) the digital collaboration between tourism departments at some universities in Malang Raya with some hotel companies and the Association of the Indonesian Tours and Travel Agencies; b) the digitalization of small and medium enterprises collaboration in Malang Raya, Indonesia such Batu Local Guide; c) online taxi which operated in Malang Raya destinations namely Grab and Uber to facilitate international tourists reach the destinations; d) for improving digital tourism communication network, Malang Raya has Malang Tourism Information Centre; e) Malang Raya destinations collaborated with smartphone sim card providers in tourism information services; f) Malang Raya has ngalam.co, and gumebyar.malangkab.go.id to integrate destination information and accommodations.
Formation of entrepreneurial values through communication in entrepreneurial interactions in coastal areas
Authors: Subekti Priyo , Bajari Atwar , Sugiana Dadang , Hafiar Hanny
Published: August 2024

This study examines how entrepreneurial values are fostered through interaction and communication between local and migrant entrepreneurs in coastal tourism areas. The study emphasizes the critical role of a shared understanding of these values, highlighting the need to promote local economic growth and develop a sustainable entrepreneurial ecosystem. Research objectives: This study aims to identify the factors that drive entrepreneurial values among local and migrant entrepreneurs in coastal tourism areas. Methods: A qualitative research approach was used, and data was collected through interviews and observations. The study focused on micro, small, and medium enterprises (MSMEs) operating in Pangandaran. The research shows that essential attributes of business success - such as grit, new ideas, and a willingness to stand on one’s own two feet - come from life experiences and the give-and-take within the community and culture. Both local entrepreneurs and travelers can use social connections and circles as tools for growth and support. At the heart of this discovery? These sociable traits are passed down through different groups, while language skills are spread across many places. Together, they create resilient people skilled in business and entrepreneurship. This Recommendation focuses on increasing collaboration between entrepreneurs through mentoring programs, workshops, and networking events to encourage the exchange of knowledge and experience. These initiatives are expected to increase innovation, competitiveness, and business sustainability in coastal tourism, strengthening the entrepreneurial ecosystem.
Causes of accidents in electrical distribution networks (using the example of the branch of PJSC Rossetti Volga – Saratov Distribution Networks)
Authors: Naumov I. V.
Published: August 2024

The article is a continuation of a series of studies dedicated to the analysis of power transmission through distribution electric networks of PJSC ROSSETI. The presented material analyzes the functioning of the electrical networks of the branch of PJSC Rosseti Volga – Saratov Distribution Networks. An analytical assessment of the electric energy transport through distribution electric networks was carried out for the period 2018–2022. The structure of the company is considered, the structural characteristics of the main elements of the studied electrical networks are given, and the number of emergencies that occurred during the study period is estimated. A quantitative assessment of the magnitude of the electric energy undersupply caused by power supply interruptions is given. The classification of failures according to the degree of the intensity of undersupply was carried out and a quantitative assessment of each group of failures according to their intensity was made. The influence of the seasonal component on the number of emergencies during the study period is considered. Based on the data from 2022–2023, the analysis of the main causes of damage to the elements of electrical networks was carried out. The classification of failures by groups of failure causes is made, their main characteristics for this period are considered. The percentage ratio of the number of failures number for the most characteristic reasons to the total number of outages during the study period has been established. The information published in the open press was used as the source data. General scientific methods as well as numerical methods of analysis were used in the research. MATLAB graphics editor technologies were used to visualize the obtained analysis results. The results obtained may be of interest to the managers of power grid companies, as well as researchers and engineers engaged in research in the field of reliability of power supply.
Implementasi Strategi Pendidikan Multikultural Berbasis Kearifan Lokal di Sekolah Dasar
Authors:   Institut Agama Islam Negeri (IAIN) Kediri,, Ridwanulloh M. Ubaidillah , Huda Rizkiana Putri Rohmatul , Surur Agus Miftakus , Maslahah Hanum Mir'atul ,   Universitas Islam Negeri (UIN) Maulana Malik Ibrahim Malang
Published: August 2024

Tujuan penelitian ini untuk mendeskripsikan implemetasi strategi pendidikan multicultural di SDI NU Pare yang menggunakan pendekatan kearifan local dalam prosesnya. Melalui penerapan nilai-nilai pendidikan multikultural diharapkan siswa atau peserta didik mampu mengoptimalkan pola pikir dan pengetahuannya pada nila-nilai karakter berbasis multikultural serta akhlak sehingga terwujud dalam perilaku Multikulturalisme di dalam masyarakat. Metode penelitian menggunakan pendekatan deskriptif kualitatif yang menggambarkan secara rinci dan mendalam objek yang sedang dibahas. Hasil penelitian menunujukkan implemetasi pendidikan multicultural berjalan dengan baik sesuai dengan yang direncanakan. Diantara strategi implementasinya membangun dan menanamkan sikap gotong royong, toleransi, Bersatu dalam keragaman dan saling menghormati serta tenggang rasa, dan membangun komunikasi lintas budaya. Selain strategi itu, SDI NU Pare menggunakan strategi komunikasi Bahasa local atau Bahasa jawa pada saat di sekolah di hari-hari tertentu. Tujuannya untuk mengenalkan budaya local setempat serta melestarikannya melalui komunikasi formal. Implementasi pendidikan multicultural dari hasil penelitian diharapkan dilakukan oleh lembaga pendidikan lain serta dikembangkan lebih lanjut agar nilai karakter berbasis multicultural dapat tertanam dengan baik pada peserta didik.
El derecho del trabajo. Un análisis crítico
Authors: Lóyzaga de la Cueva Octavio Fabián
Published: August 2024

El día 13 de noviembre del año 2012 el Congreso General de los Estados Unidos Mexicanos (Congreso de la Unión), decidió aprobar la tan anunciada reforma a la Ley Federal del Trabajo (LFT), pese a que la misma no atiende a las verdaderas necesidades de los trabajadores, pues disminuye sus derechos al tiempo que otorga más beneficios a los patrones. Ante la situación, resulta indispensable analizar las relaciones laborales individuales y colectivas de manera crítica e interdisciplinaria, pues es sumamente importante explicar los diversos mecanismos legales que han utilizado los poseedores del capital para disminuir los derechos de los trabajadores. Se observa y analiza a fondo los problemas a los que se enfrentan los trabajadores, exponiendo la necesidad de comprender las leyes para demostrar la ineficacia del sistema al no cumplir con su cometido principal: la protección de los derechos laborales. En contexto, esta obra pretende sumarse al esfuerzo de otros investigadores para buscar diversas alternativas que mejoren las condiciones de vida de los trabajadores, asimismo se plantea que urge una verdadera reforma laboral que atienda a las necesidades reales de la sociedad.
The Measurement of Narcissism in Asian, Caucasian, and Hispanic American Women
Authors: Smith Bradford M.
Published: August 2024

This study compared scores on the 40-item Narcissistic Personality Inventory for 14 Asian, 58 Caucasian, and 16 Hispanic American college women. Asian American women had significantly lower narcisissim scores than Caucasian American women and also scored significantly lower on four of the seven component scales. Hispanic and Caucasian women had similar scores on narcissism. These results may be based on an ethnic response set and/or the influence of cultural values present in many traditional Asian cultures which are seemingly antithetical to narcissism and include modesty, respect for authority, and the valuing of relationships over individualism. The importance of including ethnic information in research is stressed.
Energy Efficiency Process Improvement in the Indian Real Estate Industry
Authors: Ariyil Prajin , Weerakoon Thilina Ganganath
Published: August 2024

This study addresses the significant environmental impact of the rapidly expanding Indian real estate sector by examining energy efficiency practices through building information modelling (BIM) simulations. Employing a mixed-method approach, the research combines qualitative data from reputable literature sources and quantitative data collected via a questionnaire survey, chosen for its practicality and effectiveness in reaching a large sample size. The statistical approach involves factor analysis, utilizing the Kaiser–Meyer–Olkin (KMO) test and principal component analysis (PCA) to explore underlying data structures and identify key variables. Findings highlight the importance of boosting BIM adoption, customizing energy efficiency measures to local contexts, fostering industry collaboration, implementing monitoring mechanisms, and investing in research and development. These recommendations aim to guide industry stakeholders, policymakers, and researchers in promoting sustainable development and enhancing energy efficiency in the Indian real estate market.
System change in practice: A report from the EHC Think Tank workstreams on Access Equity and Future Care Pathways
Authors: Gacser Zita , Bourke Steven , Hosszú Dalma , Daniels Susan
Published: August 2024

Introduction

The European Haemophilia Consortium (EHC) Think Tank was established as a platform for system change to ensure the healthcare ecosystem remains effective and relevant for people with bleeding disorders and other rare diseases. Operating alongside traditional advocacy initiatives, it comprised a series of thematic workstreams in which multiple stakeholders explored and co-designed potential solutions for specific aspects of the healthcare system. This final report from the workstreams on Access Equity and Future Care Pathways summarises recommendations for system change and the actions needed to achieve critical goals.

Methodology/Process

In a three-phase Discovery-Strategy-Innovation process, workstream participants explored vital challenges to the system in which they were working, mapped the system to identify enablers and constraints to progress, and determined leverage points to explore strategies for change before co-creating a set of recommendations for action.

Results

Participants in the Access Equity workstream identified a need for evidence-based narratives to drive policy change by effectively reaching and engaging target audiences. Fostering trust among stakeholders, supported by ‘open, active listening’, was seen as essential for progress towards access equity, as was promoting value-based frameworks by ensuring that decision-makers understand the broader impact of progress in access equity for health improvement. Participants in the Future Care Pathways workstream focused on digitalisation, patient preferences and financial incentives as drivers of progress towards creating seamless, personalised care pathways that can be measured effectively. Recommendations included fostering a coordination mindset and culture, encouraging patients to take ownership of their digital healthcare records, and enabling personalised care plans through flexibility in care pathways.

Conclusions

Among the co-created, innovative strategies and recommendations proposed by workstream participants, key elements to support system change in Access Equity and Future Care Pathways, respectively, include demonstrating value through evidence-based narratives and integrating digital technology into care pathways to enhance patient-centred care. Appropriate capacity-building for all stakeholders, particularly healthcare professionals (HCPs) and patients, will be essential for the success of these initiatives.
A Tri-port DC-DC Converter for Bifacial PV Panels Coupled with Energy Storage
Authors: Sahu Preeti Kumari , Sivakrishna Karpana , Batzelis Efstratios I. , Chakraborty Chandan , Roy J. N.
Published: August 2024

The power output of photovoltaic (PV) systems, especially bifacial modules, varies due to daily fluctuations in irradiance and temperature. Maximising the efficiency and power extraction are considered crucial. Hybrid DC off-grid topologies are highly promising for rural electrification with solar energy and battery backup. These systems, tailored for household appliance use, feature low semiconductor count, continuous current ports for PV, battery and DC loads, low-voltage levels for PV and battery, voltage regulation for DC loads, maximum power point tracking (MPPT), proper battery charging and discharging, high-voltage boosting without low-frequency transformers and reduced power converter stages. However, the existing schemes often lack the above-mentioned critical features. Hence, this paper proposes a novel three-switch tri-port converter with integrated energy storage for stand-alone bifacial PV applications, with modelling and experimental validation. The battery serves as an energy storage component, regulating the DC link voltage for consistency. This paper underscores PV system power optimisation and introduces a novel tri-port converter for stand-alone bifacial PV setups, emphasising energy storage’s role in voltage regulation.
Bioenergetic analysis and anthropometric evaluation of bra-breast interface for improved design and breast health
Authors: Hamandi Farah , Pooler Taylor , Runser Alicia , Asman Carmen , Bailey Rachel , Robinson Nicole , Goswami Tarun
Published: August 2024

Bioenergetics analysis of bra-breast Interface is an important technique for improving the design of bras and promoting breast health and comfort during physical activity. The objective of this study is to evaluate the compatibility between the anatomy of the breasts and bra. The study encompasses breast anthropometry via measurement. A measurement topology was proposed to determine breast mass, volume, shape, and asymmetry under loading (with-bra) and unloading (without-bra). Using the anthropometric data, the bioenergetics of the breasts were determined and compared to the rest of the body. From the bioenergetic analysis, a larger breast could require up to 69 J of energy during walking. The average mass of a breast ranges from 500 to 1000 g. Assuming breast shape to be standard, semi-conical, semi-spherical and semi-elliptical, breast volume was determined where semi conical and semi spherical breast shapes consistently predicted lower bound volume for each breast, whereas the standard and semi elliptical breast shapes predicted higher volume for the same breasts measurements. Mathematically, the medial-lateral boundaries of the breast were described by a secant of a curve, aligned on the coronal plane, causing eccentric loading when the two breast nipples were on different transverse planes. When this variation was more than 5% volume change, asymmetric breast shapes occurred and was responsible to displace bra heterogeneously compromising fit and support. A non-linear, leaf-function describing the relationship between the breast radius and volume invoked at a given body weight. In general, the current design for a bra assumes that the breasts are symmetrical, though the current investigation proves that this is not the case. The bra needs to be redesigned to better fit women, since left and right sides are not symmetrical. This is a significant problem today, as it is estimated that nearly 80% of women wear incorrectly- sized bras; 70% wore bras that are too small, and 10% wore bras that are too big. Current investigation highlights the crucial importance of incorporating the distance between the nipples into bra design to achieve optimal support, comfort, symmetry, and minimize breast movement. It ensures that the bra cups are positioned optimally to provide effective support and enhance the natural shape of the breasts. If the current bra models are redesigned, the amount of discomfort in women could potentially decrease.
Paciente psiquiátrico de difícil manejo, redução de leitos e fechamento das Casas de Custódia no Brasil
Authors: Teixeira Eduardo Henrique , Faria Beatriz Telles , Marti Giovanna Chiavegatti de Castro Fagan , Fernandes Mariana Nocera Marin
Published: August 2024

Este trabalho tem o objetivo de ampliar a discussão em relação às dificuldades de manejar o paciente grave que necessita de uma internação em uma enfermaria psiquiátrica. Alerta para o agravamento da situação de  forma progressiva, podendo se intensificar ainda mais com o fechamento das Casas de Custódia no Brasil.
Effect of Model Fidelity on High-Speed Aeroelastic Behavior of a Cantilever Plate
Authors: Thayer Jordan D. , McNamara Jack J.
Published: August 2024

Turbulence, flow separation, and shock dynamics challenge the modeling and analysis of high-speed aeroelastic behavior. Motivated by this, the importance of modeling the fidelity of the flow is explored in the aeroelastic response of a cantilever plate in an [Formula: see text] separating turbulent flow using unsteady Reynolds-averaged Navier–Stokes (URANS) and URANS-enriched local piston theory (LPT). Structural modeling assumptions are also evaluated using both linear and nonlinear representations. Close agreement in the predicted aeroelastic steady state is observed. However, large discrepancies in the dynamic aeroelastic response predictions are found and ultimately linked to the neglect of deformation-induced cavity pressure fluctuations and dynamic flow separation in the LPT model. Interestingly, the dynamic flow separation induces a fluid-driven limit cycle oscillation in the postflutter regime. Furthermore, structural nonlinearity is not found to have a strong impact on the conditions and configurations considered.
Coupling Independent Solid Mechanics-Based Systems in a System-of-Systems Modeling Framework
Authors: Shahriar Adnan , Montoya Herta , Majlesi Arsalan , Avila David , Montoya Arturo
Published: August 2024

Modularity is essential for ensuring the efficient execution of system-of-systems (SoS) frameworks, demanding the managerial and operational independence of constituent systems. This study explores the feasibility of enforcing displacement compatibility between two interconnected, independent solid mechanics finite element models with a contact interface within an SoS. This work developed an approach that ensures operational independence by delaying displacement compatibility in one of the systems. The lagged system provides a trial displacement input to the leading system, which determines the displacement discrepancy between both systems. This error is used to calculate an equivalent pressure that enforces displacement compatibility between the models. The method was verified by modeling two specimens with a frictionless contact interface and comparing the results against a continuous model assuming a perfect bond between the specimens. Lastly, the method was implemented within an SoS for space habitats and proved effective in ensuring matching displacements at the contact surface between two interacting structural layers. The proposed approach preserves the modularity of coupled systems, avoiding complex iterative procedures and transferring mass and stiffness information between systems. Moreover, it allows the coupled models to be developed in independent coordinate systems, as they only pass scalar, coordinate-independent parameters through the input–output ports.
In Situ Imaging of Parachute Textile Micromechanics Under Tensile Load
Authors: Phillippe Cutler A. , Panerai Francesco , Roca Laura Villafañe
Published: August 2024

Micromechanics of parachute fabrics under tensile loads are studied using in situ x-ray microtomography. Results are presented for two nylon textiles commonly used in parachute systems, MIL-C-7020H Type III and MIL-C-44378(GL) Type II. Textiles are subjected to incremental tension using a custom apparatus that loads the fabric radially, and the microstructure is imaged sequentially at steady load conditions. Microtomography images are processed using learning-aided segmentation and a custom processing pipeline that tracks the locations and morphological properties of individual tows on 3D datasets. Results are used to reconstruct tow microscale properties and meso-scale strains. Our findings reveal a direct relation between the fabric architecture and the meso-scale mechanics. Warp tow pretensioning during manufacturing is found to affect decrimping and the anisotropy of the textile strains. Areal porosity increase with tension is quantified, and a geometric model for pore opening under incremental load is validated.
Family Support for Maternal Health and Child Care during the First 1,000 Days of a Child's Life: An Exploration of the Experiences of Urban Families
Authors: Wiradnyani Luh Ade Ari , Khusun Helda , L. Achadi Endang , Ocviyanti Dwiana
Published: August 2024

This qualitative study examines the families' support regarding maternal health and child care toward mothers who demonstrated Good Compliance (GC) and Poor Compliance (PC) with nutrition interventions during the first 1,000 days of their child's life. The study employed an in-depth interview method to gather data from 20 fathers and 7 grandparents residing in Bogor City. The data were analyzed using a constant comparison approach between the GC and PC groups for each theme. The findings indicated that family members provided more specific support for child feeding than for maternal Iron-Folic Acid Supplementation (IFAS), given that the mothers encountered more difficulties on child feeding. Encouraging the mothers to continue taking IFA supplement despite their hesitance was predominantly reported by fathers in the GC fathers. Regarding child feeding, in addition to encouraging the child to eat and feeding them, the GC fathers often engaged in discussions with their wives. In contrast, the PC fathers rarely engaged in such discussions and were only consulted when their wives reported problem. Furthermore, fathers considered their wives to be more knowledgeable on these issues as fathers had limited time due to work commitment. Grandmothers primarily offered advice on child feeding based on their own experiences, sometimes providing less suitable advice for PC mothers. While fathers in both groups did not proactively seek information about maternal health and child care, the GC fathers were more likely to be encountered such information through discussions initiated by their wives, prompting them to pursue further reading. The interaction of fathers in both groups with health professionals only occurred during antenatal visits, with minimal communication. It is recommended that strategies be developed to engage family more highlight their crucial role in fostering a supportive environment for mothers. It is aslo advised that antenal visits be optimized and the Maternal and Child Health (MCH)handbook be utilized to raise awareness and enhance paternal involvement.
Advancements in siRNA delivery using nanotechnology for reproductive tract cancers: From targeting to enhancing treatment efficacy
Authors: Jangde Krishna Kant , Mishra Dinesh Kumar
Published: August 2024

Cancers of the reproductive system, which include those of the cervix, uterus, ovaries, fallopian tubes, and vagina, are major global health concerns. Even with improvements in traditional therapies such as radiation and chemotherapy, managing these tumors is still difficult, frequently associated with side effects, and has limited effectiveness. Targeted cancer therapy now has better options, thanks to the development of small interfering ribonucleic acid (siRNA) as a potentially effective therapeutic procedure through the ribonucleic acid interference (RNAi) technique in recent years. Nevertheless, there are many challenges in the clinical translation of siRNA, especially in terms of delivering drugs effectively to tumor-specific areas while reducing off-target effects. Nanotechnology has emerged as a transformative perspective that could show a promising approach for providing a revolutionary solution to the problems related to siRNA delivery. By carefully crafting nanocarriers, including liposomes, polymeric nanoparticles, and lipid nanoparticles, scientists have made incredible strides toward improving the bioavailability, stability, efficacy, and selectivity of siRNA treatments. Furthermore, due to their customizable characteristics, nanocarriers could be used to target specific tumors of the reproductive tract, enhancing the effectiveness of the treatment by taking advantage of tumor-specific indicators and microenvironments. In this review, we will summarize and delve into leveraging the synergistic benefits of targeted delivery and enhanced therapeutic potency using the RNAi technique. These innovative strategies hold immense potential to reshape the treatment landscape, offering new hope for patients with these devastating reproductive tract malignancies.
ФОРМИРОВАНИЕ СИСТЕМЫ НЕОБХОДИМЫХ УСЛОВИЙ И ФАКТОРОВ РАЗВИТИЯ ТОПЛИВНО-ЭНЕРГЕТИЧЕСКОГО КОМПЛЕКСА РОССИИ: УПРАВЛЕНЧЕСКИЙ АСПЕКТ
Authors: Журавлев А.С.
Published: August 2024

В научной статье представлены результаты анализа системы необходимых условий и факторов развития топливно-энергетического комплекса России, состоящей из управленческих решений менеджмента компаний и мероприятий государственной поддержки органов власти. Актуальность исследования обусловлена тем, что современный период развития топливно-энергетического комплекса России связан с влиянием ряда негативных факторов, препятствующих экономической деятельности организаций. И из-за этого важно формирование системы необходимых условий и факторов развития отрасли, что возможно при помощи управленческих решений менеджмента компаний ТЭК, а также мероприятий государственной поддержки управленческих органов власти. Поэтому в научной статье проведена оценка текущего состояния данной отрасли с учетом конкуренции на международном рынке топливно-энергетических ресурсов и продукции. После этого предложены управленческие решения, которые руководители организаций топливно-энергетического комплекса России могут применять в целях обеспечения развития управляемого бизнеса, а также перечислены инструменты государственного управления, которые можно применять в целях развития ТЭК.
АНАЛИЗ ТРАНСФОРМАЦИИ ВЗГЛЯДОВ К. МАРКСА НА ПРИБАВОЧНУЮ СТОИМОСТЬ КАК ЕДИНСТВЕННЫЙ ИСТОЧНИК ПРИБЫЛИ.
Authors: Петухов В.А.
Published: August 2024

Аннотация Статья посвящена эволюции взглядов Маркса на прибавочную стоимость как единственный источник прибыли. Автор показывает, что поздний Маркс, рассматривая случаи удорожания и удешевления элементов постоянного капитала, приходит в выводу, что прибыль и прибавочная стоимость являются разными величинами, и что, следовательно, постоянный капитал зачастую воспроизводится не той стоимостью, которую он перенес на продукт. Тем самым Маркс, оставаясь в рамках своей теории, тем не менее частично начинает склоняться к мнению, что станки и оборудование тоже способны создавать прибыль. Также автор с точки зрения своего подхода указывает на необходимые последующие выводы из данного анализа, – а именно, признание того, что различные биологические (в т.ч. и живой человек) и небиологические механизмы могут создавать прибыль для предпринимателя.
РАЗВИТИЕ ВЫЕЗДНОГО И ВНУТРЕННЕГО ТУРИЗМА В РОССИИ В СОВРЕМЕННЫХ ГЕОПОЛИТИЧЕСКИХ УСЛОВИЯХ
Authors: Виноградова А.В. , Гриневич Ю.А.
Published: August 2024

За последние 10 лет тенденции в развитии туризма значительно поменялись. Основополагающими факторами, повлекшими эти изменения стали: пандемия Covid 19 и изменения геополитической ситуации (в частности санкции, введенные правительствами ряда зарубежных стран). Данное исследование направлено на изучение современного состояния туристической отрасли в России, оценке положительных и отрицательных последствий вышеперечисленных событий, рассмотрению возможных направлений дальнейшего развития. Проведено сравнение различных показателей туристического развития по разным странам, определены государства, которым удалось достичь на 2023 год допандемийного уровня, а также представлена характеристика наиболее перспективных регионов РФ для внутреннего туризма. Для повышения конкурентоспособности и привлекательности российского туристического рынка охарактеризованы меры государственной поддержки и поставщиков туристических услуг, и платежеспособного спроса со стороны покупателей.
РЕКОМЕНДАЦИИ ПО УЧЕТУ РАСЧЕТОВ ПО ОПЛАТЕ ТРУДА В УСЛОВИЯХ СЕЗОННЫХ РАБОТ
Authors: Стафиевская М.В. , Роман В.М.
Published: August 2024

Вознаграждение за труд работнику в соответствии со сложностью работ, качеством, количеством является его заработной платой. Предметом исследования является деятельность по производству пиломатериалов конкретного предприятия. Целью исследования является совершенствование учета расчетов с персоналом по оплате труда с учетом специфики предприятия. Изложенная методика в статье и подходы к совершенствованию, могут быть полезны руководителям и бухгалтерам коммерческих организаций. В процессе исследования использовались следующие методы исследования: анализ, наблюдение, обобщение и классификация информации, эмпирические методы, формализация, конкретизация, аналогия. Практическая значимость результатов исследования состоит в том, что использование разработанных рекомендаций посодействует совершенствованию организации учета расчетов с персоналом по оплате труда на предприятиях, связанных с сезонным характером работы. Рекомендации, представленные в статье, могут быть использованы при чтении лекционных и семинарских занятий по финансовому учету.