bluuebunny/crossref_metadata_2025 huggingface dataset:
Nondrowning Asphyxia in Veterinary Forensic Pathology
Authors: McEwen B. J.
Published: April 2016

Asphyxia in a forensic context refers to death by rapid cerebral anoxia or hypoxia due to accidental or nonaccidental injury. Death due to nondrowning asphyxia can occur with strangulation, suffocation, and mechanical asphyxia, each of which is categorized based on the mechanism of injury. Individuals dying due to various types of asphyxia may or may not have lesions, and even those lesions that are present may be due to other causes. The interpretation or opinion that death was due to asphyxia requires definitive and compelling evidence from the postmortem examination, death scene, and/or history. Beyond the postmortem examination, pathologists may be faced with questions of forensic importance that revolve around the behavioral and physiological responses in animals subjected to strangulation, suffocation, or mechanical asphyxia to determine if the animal suffered. While there is no prescriptive answer to these questions, it is apparent that, because of physiological and anatomical differences between humans and animals, for some mechanisms of asphyxia, consciousness is maintained for longer periods and the onset of death is later in animals than that described for people. Veterinary pathologists must be cognizant that direct extrapolation from the medical forensic literature to animals may be incorrect. This article reviews the terminology, classification, mechanisms, and lesions associated with asphyxial deaths in companion animals and highlights significant comparative differences of the response to various types of asphyxia in animals and people.
Functional interictal changes of pain processing in migraine with ictal cutaneous allodynia
Authors: Russo Antonio , Esposito Fabrizio , Conte Francesca , Fratello Michele , Caiazzo Giuseppina , Marcuccio Laura , Giordano Alfonso , Tedeschi Gioacchino , Tessitore Alessandro
Published: April 2016

Objective

A prospective clinical imaging study has been conducted to investigate pain processing functional pathways during trigeminal heat stimulation (THS) in patients with migraine without aura experiencing ictal cutaneous allodynia (CA) (MwoA CA+).

Methods

Using whole-brain BOLD-fMRI, functional response to THS at three different intensities (41°, 51° and 53℃) was investigated interictally in 20 adult MwoA CA+ patients compared with 20 MwoA patients without ictal CA (MwoA CA−) and 20 healthy controls (HCs). Secondary analyses evaluated associations between BOLD signal change and clinical features of migraine.

Results

During moderate-noxious THS (51℃), we observed a significantly greater activation in (a) the anterior cingulate cortex in MwoA CA+ patients compared to HCs and (b) the middle frontal gyrus in MwoA CA+ patients compared to both MwoA CA− patients and HCs. Furthermore, during high-noxious THS (53℃) a significantly decreased activation in the secondary somatosensory cortices was observed in (a) MwoA CA− patients compared to both MwoA CA+ patients and HCs and (b) MwoA CA+ patients compared to HCs. CA severity was positively correlated with the secondary somatosensory cortices activation.

Conclusions

Our findings suggest that CA may be subtended by both a dysfunctional analgesic compensatory mechanism and an abnormal internal representation of pain in migraine patients.
The Association Between Serum Biomarkers of Collagen Turnover and Subsequent Anterior Cruciate Ligament Rupture
Authors: Svoboda Steven J. , Owens Brett D. , Harvey Travis M. , Tarwater Patrick M. , Brechue William F. , Cameron Kenneth L.
Published: April 2016

Background:

No study has attempted to associate the levels of preinjury serum biomarkers of collagen turnover with the subsequent risk of anterior cruciate ligament (ACL) injury.

Hypothesis:

Preinjury serum biomarkers of collagen turnover would be associated with the subsequent risk of ACL injury.

Study Design:

Case-control study; Level of evidence, 3.

Methods:

We conducted a case-control study with 45 ACL-injured cases and 45 controls matched for sex, age, height, and weight. In addition to the matching criteria, controls had no history of major joint injury. Baseline preinjury serum samples were obtained from the Department of Defense Serum Repository for all subjects. Samples were assessed for 2 serum biomarkers of collagen synthesis (CPII and CS846) and 2 markers of collagen degradation (C1,2C and C2C) through commercially available enzyme-linked immunosorbent assay (ELISA) kits. All ELISAs were performed in triplicate. Conditional logistic regression models were used to analyze the data.

Results:

Univariate results suggested that both biomarkers for collagen degradation (C1,2C and C2C) were significantly associated with the subsequent likelihood of ACL injury. Serum C2C and C1,2C concentration at baseline were associated with odds ratios (ORs) of 2.05 (95% CI, 1.30-3.23; P = .001) and 3.02 (95% CI, 1.60-5.71; P = .002), respectively. Baseline serum CPII concentrations were also associated with subsequent ACL injury. Serum CPII concentration at baseline was associated with an OR of 4.41 (95% CI, 1.87-10.38; P = .001). Baseline serum CS846 levels approached significance (OR = 0.77; 95% CI, 0.57-1.03; P = .080). Multivariable models suggested that preinjury CPII and C2C concentrations at baseline are important indicators of subsequent ACL injury risk.

Conclusion:

Preinjury differences in serum biomarker levels of collagen turnover suggest that collagen metabolism in individuals who go on to tear an ACL may be different when compared with a matched control group with no history of major joint injury. These differences may be reflective of different preinjury biochemical and/or biomechanical risk profiles or genetic factors that subsequently affect both collagen metabolism and ACL injury risk.
Outcome Trajectories among Homeless Individuals with Mental Disorders in a Multisite Randomised Controlled Trial of Housing First
Authors: Adair Carol E. , Streiner David L. , Barnhart Ryan , Kopp Brianna , Veldhuizen Scott , Patterson Michelle , Aubry Tim , Lavoie Jennifer , Sareen Jitender , LeBlanc Stefanie Renée , Goering Paula
Published: April 2016

Purpose:

Housing First (HF) has been shown to improve housing stability, on average, for formerly homeless adults with mental illness. However, little is known about patterns of change and characteristics that predict different outcome trajectories over time. This article reports on latent trajectories of housing stability among 2140 participants (84% followed 24 months) of a multisite randomised controlled trial of HF.

Methods:

Data were analyzed using generalised growth mixture modeling for the total cohort. Predictor variables were chosen based on the original program logic model and detailed reviews of other qualitative and quantitative findings. Treatment group assignment and level of need at baseline were included in the model.

Results:

In total, 73% of HF participants and 43% of treatment-as-usual (TAU) participants were in stable housing after 24 months of follow-up. Six trajectories of housing stability were identified for each of the HF and TAU groups. Variables that distinguished different trajectories included gender, age, prior month income, Aboriginal status, total time homeless, previous hospitalizations, overall health, psychiatric symptoms, and comorbidity, while others such as education, diagnosis, and substance use problems did not.

Conclusion:

While the observed patterns and their predictors are of interest for further research and general service planning, no set of variables is yet known that can accurately predict the likelihood of particular individuals benefiting from HF programs at the outset.
Descriptive Epidemiology of Generalized Anxiety Disorder in Canada
Authors: Watterson Rita A. , Williams Jeanne V. A. , Lavorato Dina H. , Patten Scott B.
Published: April 2016

Objective:

The first national survey to assess the prevalence of generalized anxiety disorder (GAD) in Canada was the 2012 Canadian Community Health Survey: Mental Health and Well-Being (CCHS-MH). The World Mental Health Composite International Diagnostic Interview (WMH-CIDI), used within the representative sample of the CCHS-MH, provides the best available description of the epidemiology of this condition in Canada. This study uses the CCHS-MH data to describe the epidemiology of GAD.

Method:

The analysis estimated proportions and odds ratios and used logistic regression modelling. All results entailed appropriate sampling weights and bootstrap variance estimation procedures.

Results:

The lifetime prevalence of GAD is 8.7% (95% CI, 8.2% to 9.3%), and the 12-month prevalence is 2.6% (95% CI, 2.3% to 2.8%). GAD is significantly associated with being female (OR 1.6; 95% CI, 1.3 to 2.1); being middle-aged (age 35-54 years) (OR 1.6; 95% CI, 1.0 to 2.7); being single, widowed, or divorced (OR 1.9; 95% CI, 1.4 to 2.6); being unemployed (OR 1.9; 95% CI, 1.5 to 2.5); having a low household income (<$30 000) (OR 3.2; 95% CI, 2.3 to 4.5); and being born in Canada (OR 2.0; 95% CI, 1.4 to 2.8).

Conclusions:

The prevalence of GAD was slightly higher than international estimates, with similar associated demographic variables. As expected, GAD was highly comorbid with other psychiatric conditions but also with indicators of pain, stress, stigma, and health care utilization. Independent of comorbid conditions, GAD showed a significant degree of impact on both the individual and society. Our results show that GAD is a common mental disorder within Canada, and it deserves significant attention in health care planning and programs.
Organizational Size and Social Capital in the Public Sector
Authors: Andrews Rhys
Published: April 2016

Organization theory suggests that the strength of the ties between employees is likely to be weaker in large organizations, but that decentralization of decision making can help generate norms of collaboration, trust, and shared mission. This article explores the separate and combined effects of size and decentralization on perceptions of organizational social capital in central government agencies in Europe. The statistical results suggest that there is a negative relationship between organization size and organizational social capital and a contrasting positive relationship between decentralized decision making and social capital. Further analysis revealed that decentralization of key decisions can overcome the internal social dysfunctions associated with being a big organization. Theoretical and practical implications are discussed.
Reflections on the Translation Into Arabic and Validation Process of the NorAQ Abuse Questionnaire
Authors: Wangel Anne-Marie , Ouis Pernilla
Published: April 2016

The use of validated instruments and questionnaires on abuse is of great importance to evaluate and compare the prevalence in different populations worldwide. However, most of the questionnaires available and published are in English. For example, the NorVold Abuse Questionnaire (NorAQ) instrument which was used for the Bidens study in six European countries. A substantial proportion of the pregnant population in the catchment area of the clinical site in Sweden is Arabic-speaking women. As abuse and violence against women is a global concern, it is important to translate these questionnaires to other languages. This process is not just merely a matter of finding a correlating word but also needs to be validated for content and consider the wording in a linguistic and cultural context. This article gives an account of the translation and content validity process and its challenges and pitfalls from Swedish and English into the Arabic language version.
‘I’ve Learned to Love What’s Going to Pay Me’: A Culture of Despair in Higher Education during a Time of Insecurity
Authors: Aronson Pamela
Published: April 2016

Based on 153 interviews at a mid-sized, commuter university, this article examines the disjuncture between students and alumni on the one hand, and faculty, academic staff and administrators on the other in their perceptions of the challenges facing students who graduate during the Great Recession. Findings reveal a culture of despair in response to economic insecurity for students and graduates: they pursued degrees primarily for a workplace credential, were fearful about the future, and experienced and expressed uncertainty in their post-college plans. While university employees were sympathetic to student problems, only a small number of faculty, staff and administrators viewed student despair as resulting from large-scale structural problems. Instead, the majority of faculty and all of the administrators and academic staff emphasized the need for an individualized response to the social problem of the Great Recession.
A Critical Assessment of Social Entrepreneurship
Authors: Frank Peter M. , Shockley Gordon E.
Published: April 2016

We offer a microfoundation of social entrepreneurship through the work of Vincent and Elinor Ostrom on polycentricity (Ostromian polycentricity) and that of Friedrich Hayek on the economics of knowledge (Hayekian knowledge) that reveals both the main strength and main weakness of social entrepreneurship. Problematizing social entrepreneurship in terms of the political economy of knowledge and based on Ostromian polycentricity and Hayekian knowledge, we first find the main strength of social entrepreneurship is that local, decentralized social entrepreneurs usually are the most appropriate and best-positioned—indeed, the most efficient—actors to solve their communities’ social problems. Also based on the work of the Ostroms and Hayek, we identify the main weakness of social entrepreneurship: the lack of institutional safeguards to social entrepreneurship. The localized decision-making process, however, might mitigate to some degree the potential for large-scale abuse.
A segment feedrate profile fitting method for parametric interpolation
Authors: Lu Lei , Zhang Lei , Ji Shijun , Song Dunlan , Zhao Ji
Published: April 2016

There are many researches in scheduling an optimal feedrate profile under various constraints by numerical calculation. A large number of discrete feedrate data points are obtained. They are inconvenient for the parametric interpolator. Therefore, these discrete feedrate data points need to be fitted by parameter curves. Different from the regular curve fitting, the inappropriate feedrate fitting method can generate larger acceleration and jerk that seriously affect the machining accuracy and stability, although the feedrate satisfies the error requirements. In order to generate a suitable feedrate profile, a segment feedrate profile fitting method using B-spline is proposed in this article. The discrete feedrate data points are segmented in the jerk discontinuous points. In each segment, the feedrate profile is fitted by the linear least squares method. These fitted feedrate profiles are combined to generate a unified feedrate profile. The unified fitted feedrate profile and the tool path trajectory are used in the controller to command the axis. In this article, the process of parametric interpolation is separated into the arc-length calculation process and the curve parameter calculation process. Using parallel computation, the two processes are calculated simultaneously in the controller, and the computational efficiency is improved. Both simulation and experiment are carried out to verify that the fitted feedrate profile satisfies the error requirements, and the novel interpolation can be applied to the controller appropriately.
A parametric interpolation method with minimal feedrate fluctuation by nonuniform rational basis spline
Authors: Lu Lei , Zhang Lei , Gu Yan , Zhao Ji
Published: April 2016

Because the relation between the arc length s and curve parameter u cannot be represented by explicit function for most of the curves, it is difficult to consider the accuracy, robustness, and computational efficiency for most of the parametric interpolation, especially when the curves are complex or extremes. Therefore, an off-line fitting interpolation method by using nonuniform rational basis spline is presented in this paper. As nonuniform rational basis spline has many geometry implementation tools and numerous good properties as compared to the polynomial, the required fitting accuracy can be obtained more easily than with polynomial. After the de Boor method is applied, the computational load of nonuniform rational basis spline is decreased as compared to the Taylor approximation and the higher order polynomial fitting method. In order to obtain the proper s-u fitting nonuniform rational basis spline and reduce the computational load of the fitting process, the sampled s-u data points are divided according to the properties of nonuniform rational basis spline, and in each segment, the knot vectors, control points, and weights are calculated by the iterative-optimization method. Then the s-u nonuniform rational basis spline can be applied in real-time interpolation, and the accuracy, robustness, and computational efficiency are demonstrated by simulations and experiments.
Vibrational analysis of single-layered silicon carbide nanosheets and single-walled silicon carbide nanotubes using nanoscale finite element method
Authors: Ansari R , Rouhi S
Published: April 2016

A three-dimensional finite element model has been used here to study the vibrational behavior of silicon carbide nanosheets and nanotubes. The bonds of hexagonal lattices of SiC nanosheets have been modeled by structural beam elements, and at the corners, mass elements are placed instead of Si and C atoms. Moreover, molecular dynamics simulations are performed to verify the finite element model. Comparing the results of finite element model and molecular dynamics simulations, it is concluded that the utilized approach can predict the results of molecular dynamics simulations with a reasonable accuracy. It is observed that the atomic structure does not significantly affect the vibrational behavior of nanosheets. Besides, increasing the size of nanosheet results in decreasing the effect of geometry variation. As the aspect ratio of nanotubes increases, the effects of boundary conditions and length diminish so that the frequency envelopes tend to converge.
Sensitivity analysis of the wheel–rail normal contact on the basis of continuous factors
Authors: Dörner Florian , Bettinger Tobias , Schindler Christian
Published: April 2016

The exact characterization of the wheel–rail normal contact situations is essential for its wear, fatigue, and guidance analysis. To simulate this contact, numerous input parameters are required. Many of them have to be estimated. The aim of this sensitivity analysis was to investigate the direct effects and interactions of the input parameters on the contact pressure distribution of a freight wagon wheel on a straight track. For this purpose, a finite element model was parametrized in such a way that all the parameters were continuous. This research demonstrates that the output parameters of the wheel–rail contact simulations have a broad deviation and the input variable with the most influence on the contact form and position is the lateral displacement of the wheelset. Nevertheless, the profile shape of the wheel and rail, the wheel radius, and the relative wheel–rail inclination are important input parameters as well, and also need to be considered for exact simulations of the wheel–rail contact. On the other hand, the deviation of material parameters of wheel and rail steel can be neglected.
Lymphogranuloma venereum presenting with erythema nodosum
Authors: Borsje Annemiek , van der Reijden Wil , Soetekouw Robin
Published: April 2016

Lymphogranuloma venereum is a sexually transmitted infection caused by Chlamydia trachomatis serovar L1, L2 or L3. Anorectal infections in HIV-positive men who have sex with men comprise the majority of cases in the developed world. We present the case of a 30-year-old HIV-negative man with inguinal type lymphogranuloma venereum accompanied by erythema nodosum.
From Creatures of Habit to Goal-Directed Learners
Authors: Decker Johannes H. , Otto A. Ross , Daw Nathaniel D. , Hartley Catherine A.
Published: April 2016

Theoretical models distinguish two decision-making strategies that have been formalized in reinforcement-learning theory. A model-based strategy leverages a cognitive model of potential actions and their consequences to make goal-directed choices, whereas a model-free strategy evaluates actions based solely on their reward history. Research in adults has begun to elucidate the psychological mechanisms and neural substrates underlying these learning processes and factors that influence their relative recruitment. However, the developmental trajectory of these evaluative strategies has not been well characterized. In this study, children, adolescents, and adults performed a sequential reinforcement-learning task that enabled estimation of model-based and model-free contributions to choice. Whereas a model-free strategy was apparent in choice behavior across all age groups, a model-based strategy was absent in children, became evident in adolescents, and strengthened in adults. These results suggest that recruitment of model-based valuation systems represents a critical cognitive component underlying the gradual maturation of goal-directed behavior.
Deconstructing “real” women: Young women's readings of advertising images of “plus-size” models in the UK
Authors: Beale Katie , Malson Helen , Tischner Irmgard
Published: April 2016

Critical feminist researchers and others have amply elucidated the perniciousness of contemporary Western beauty ideals and, particularly, the near-ubiquitous idealisations of slenderness. In this context, the advent of media images featuring “plus-size” models has been rightly heralded as a welcome challenge to this hegemony. Yet, little attention has been given to women's interpretations of these images. In this brief report, we outline a preliminary exploration of young women's views about advertising images featuring “plus-size” models in the UK. We used a discourse analytic method to analyse 35 young women's responses to a qualitative questionnaire asking for their views and feelings about three adverts featuring “plus-size” models. Our analysis suggests that, while the models were positively construed, participants also drew on distinctly conservative notions of femininity such that romanticised constructions of a “plus-sized”, traditional and domestic femininity were contrasted with a highly pejorative framing of “stick thin” women as vain, vindictive and self-obsessed. Our analysis thus indicates how representations of women focusing on body weight and shape can, even when reclaiming “fat” or “plus-size” bodies, mobilise derogatory and constricting rather than empowering constructions of femininity.
Middle-to late-Holocene environmental changes in the Garigliano delta plain (Central Italy): which landscape witnessed the development of the Minturnae Roman colony?
Authors: Bellotti Piero , Calderoni Gilberto , Dall’Aglio Pier Luigi , D’Amico Carmine , Davoli Lina , Di Bella Letizia , D’Orefice Maurizio , Esu Daniela , Ferrari Kevin , Bandini Mazzanti Marta , Mercuri Anna Maria , Tarragoni Claudia , Torri Paola
Published: April 2016

Geomorphologic, stratigraphic, faunistic, palynological and 14C analyses were carried out in the area of the mouth of the Garigliano River characterized by two strand plains that are referred to the Eutyrrhenian and the Holocene, rimming two depressed zones separated by the Garigliano River channel. This study depicts the palaeoenvironmental evolution over the last 8200 years and the landscape context at the time of Minturnae Roman colony. Between 8200 and 7500 yr BP, a wet zone occurred in the northern zone, whereas in the southern part, a lagoon developed. During the final transgression stage and the beginning of the sea level still stand (7500–5500 yr BP), a freshwater marsh formed in the northern zone, and the width of the southern lagoon decreased. Between 5500 and 3000 yr BP, the coastal barrier changed into a delta cusp, a freshwater marsh also appeared in the southern part and the river wandered between the twin marshes. Because of local uplift, previously unknown in this area, part of the floor of the southern marsh emerged, and after 4000 yr BP, both marshes became coastal ponds with prevailing clastic sedimentation. A progressive increment in anthropic forcing on the land took place after 3000 yr BP. The Marica sanctuary was built (7th century BC), and the Roman colony of Minturnae was developed beginning the 3rd century BC. The shallow depth of the ponds prevented their use as harbours, and saltwork plants can be ruled out based on the faunal and palynological data. The ongoing infilling of both ponds was never completed, and their reclamation is still in progress.
Risk of clinical deterioration in patients with lupus nephritis receiving rituximab
Authors: Manou-Stathopoulou S , Robson M G
Published: April 2016

Rituximab is a chimeric anti-CD20 monoclonal antibody that is used as an immunosuppressive agent in cyclophosphamide refractory lupus nephritis to induce remission. Although uncontrolled case series suggest efficacy, this is not yet supported by evidence from prospective randomized controlled trials. The objective of this retrospective case series is to report the clinical outcome of seven patients who received rituximab for lupus nephritis in a single centre between 2011 and 2014. One patient had clinical evidence of an uncomplicated response to therapy. A second patient responded well with the first rituximab course, but had transient worsening of renal function and nephrotic syndrome with a second course. The other five patients all had evidence of a clinical deterioration following rituximab. Two had transient worsening of both renal function and nephrotic syndrome, with subsequent evidence of response in one of these. A fifth patient showed evidence of worsening nephrotic syndrome and renal function which then improved but with renal function remaining below the level present before rituximab. A sixth developed rapidly progressive renal failure following rituximab with active nephritis on renal biopsy and required rescue therapy with high dose steroids and cyclophosphamide. A seventh developed a transient worsening of her nephrotic syndrome and an exacerbation of extrarenal symptoms following rituximab. The two patients showing a good response had complete B cell depletion and incomplete depletion may be a factor in the deterioration seen in the other patients. Our experience suggests that rituximab therapy in lupus nephritis is not without risk and patients should be informed of this beforehand. This is particularly important in view of the uncertainty that rituximab will offer a therapeutic benefit.
Posterior reversible encephalopathy syndrome and association with systemic lupus erythematosus
Authors: Ferreira TS , Reis F , Appenzeller S
Published: April 2016

Introduction

Posterior reversible encephalopathy syndrome (PRES) is a neurological complex disorder with many clinical associations and causative factors. It is important to recognize this condition because early diagnosis and treatment usually result in its complete resolution, radiological imaging becoming the key for the correct diagnosis.

Methods

We retrospectively reviewed charts and magnetic resonance imaging findings in the University of Campinas from January 2005 to July 2015, selecting three cases of patients with systemic lupus erythematosus syndrome who developed PRES, for whom risk factors, characteristics, magnetic resonance imaging findings and neurological resolution were analyzed. We also conducted a review of the English-language literature.

Results

The three cases had neurological symptoms like acute onset of headache, altered mental status, cortical blindness and seizures. Brain magnetic resonance imaging demonstrated posterior cortical and white matter alterations involving posterior brain territories, which were more conspicuous on T2-weighted and fluid-attenuated inversion recovery . Spectroscopy, diffusion-weighted imaging and susceptibility-weighted imaging were also important for neuroradiological evaluation. Immunosuppressive drugs were taken in all cases. Partial clinical and radiological recovery was observed in two cases, and complete resolution was observed in the third patient.

Literature review

We found 52 cases of PRES in systemic lupus erythematosus patients. Almost all patients were women 94%, ranging from 8 to 62 years old. Posterior brain territory involvements were found in 98% of patients. Hemorrhagic complications involved 26% of patients, becoming a risk factor for clinical sequels. The total percentage of patients with no complete resolution of radiological findings on follow-up images was 27.5%.

Discussion

In patients with autoimmune disorders, endothelial dysfunction may occur secondary to autoimmunity and the use of cytotoxic drugs, supposedly facilitating the occurrence of more severe PRES. The hypothesis that patients with autoimmune diseases have a propensity to develop non-reversible lesions has been raised.
Humoral markers of active Epstein–Barr virus infection associate with anti-extractable nuclear antigen autoantibodies and plasma galectin-3 binding protein in systemic lupus erythematosus
Authors: Rasmussen N S , Nielsen C T , Houen G , Jacobsen S
Published: April 2016

We investigated if signs of active Epstein–Barr virus and cytomegalovirus infections associate with certain autoantibodies and a marker of type I interferon activity in patients with systemic lupus erythematosus. IgM and IgG plasma levels against Epstein–Barr virus early antigen diffuse and cytomegalovirus pp52 were applied as humoral markers of ongoing/recently active Epstein–Barr virus and cytomegalovirus infections, respectively. Plasma galectin-3 binding protein served as a surrogate marker of type I interferon activity. The measurements were conducted in 57 systemic lupus erythematosus patients and 29 healthy controls using ELISAs. Regression analyses and univariate comparisons were performed for associative evaluation between virus serology, plasma galectin-3 binding protein and autoantibodies, along with other clinical and demographic parameters. Plasma galectin-3 binding protein concentrations were significantly higher in systemic lupus erythematosus patients ( P = 0.009) and associated positively with Epstein–Barr virus early antigen diffuse-directed antibodies and the presence of autoantibodies against extractable nuclear antigens in adjusted linear regressions (B = 2.02 and 2.02, P = 0.02 and P = 0.002, respectively). Furthermore, systemic lupus erythematosus patients with anti-extractable nuclear antigens had significantly higher antibody levels against Epstein–Barr virus early antigen diffuse ( P = 0.02). Our study supports a link between active Epstein–Barr virus infections, positivity for anti-extractable nuclear antigens and increased plasma galectin-3 binding protein concentrations/type I interferon activity in systemic lupus erythematosus patients.
Vocabulary of Toddlers Who Are Late Talkers
Authors: MacRoy-Higgins Michelle , Shafer Valerie L. , Fahey Katlin J. , Kaden Elyssa R.
Published: April 2016

The purpose of this study was to understand vocabulary characteristics in toddlers who are late talkers (LT) as compared with age-matched (AM) and vocabulary-matched (VM) peers. The semantic categories (e.g., animals, foods, toys) and the percentage of nouns, verbs, and closed-class words in the vocabularies of 36 toddlers (12 LT, 12 AM, 12 VM) were examined. Results indicated that the semantic categories present in the vocabularies of toddlers who were LT were similar to those of VM peers but not of AM peers. Nouns represented the largest word class in all participant groups, but the percentage of nouns in the vocabularies of toddlers who were LT was less than the percentage of nouns in the vocabularies of AM and VM peers. These findings indicate that the vocabularies of toddlers who are LT may be atypical, rather than delayed. Clinical application and potential intervention strategies are discussed.
Comparison of Removable and Irremovable Walking Boot to Total Contact Casting in Offloading the Neuropathic Diabetic Foot Ulceration
Authors: Piaggesi Alberto , Goretti Chiara , Iacopi Elisabetta , Clerici Giacomo , Romagnoli Fabio , Toscanella Fabrizia , Vermigli Cristiana
Published: April 2016

Background:

Despite its efficacy in healing neuropathic diabetic foot ulcers (DFUs), total contact cast (TCC) is often underused because of technical limitations and poor patient acceptance. We compared TCC to irremovable and removable commercially available walking boots for DFU offloading.

Methods:

We prospectively studied 60 patients with DFUs, randomly assigned to 3 different offloading modalities: TCC (group A), walking boot rendered irremovable (i-RWD; group B), and removable walking boot (RWD; group C). Patients were followed up weekly for 90 days or up to complete re-epithelization; ulcer survival, healing time, and ulcer size reduction (USR) were considered for efficacy, whereas number of adverse events was considered for safety. Patients’ acceptance and costs were also evaluated.

Results:

Mean healing time in the 3 groups did not differ ( P = .5579), and survival analysis showed no difference between the groups (logrank test P = .8270). USR from baseline to the end of follow-up was significant ( P < .01) in all groups without differences between the groups. Seven patients in group A (35%), 2 in group B (10%), and 1 in group C (5%) (Fisher exact test P = .0436 group A vs group C) reported nonsevere adverse events. Patients’ acceptance and costs were significantly better in group C ( P < .05).

Conclusions:

Our results suggest that a walking boot was as effective and safe as TCC in offloading the neuropathic DFUs, irrespective of removability. The better acceptability and lesser costs of a removable device may actually extend the possibilities of providing adequate offloading.

Level of Evidence:

Level II, prospective comparative study.
Methods for Quantifying Patterns of Dynamic Interactions in Dyads
Authors: Gates Kathleen M. , Liu Siwei
Published: April 2016

Individuals in both clinical and research settings increasingly provide data across numerous time points. Examples include measurements collected from wearable technology (e.g., accelerometers), psychophysiological measures, coded observations, social media behaviors, and daily diary data. When numerous observations are available for each individual, the data fall under the class of time series data and can be examined from within a dynamic systems perspective. We provide a broad overview of current analytic methods for quantifying relations among dyads using this data type. The techniques include those from within a linear modeling framework, approaches that include a measurement model, and methods for examining cyclical relations. We also discuss some special topics, such as methods that allow for models to shift across time and that accommodate heterogeneity across individuals. Finally, methods that account for similar shapes of nonlinear curves across time are described. From this breadth of options, we hope to help guide practitioners, clinicians, and researchers in choosing the optimal method for their data and line of questions. To further aid in this choice, we indicate programs available for each technique. Example dyads presented here range from mother–infant, patient–caretaker, and husband–wife; however, the analytic methods can be applied to any type of dyad.
Differentiating Dark Triad Traits Within and Across Interpersonal Circumplex Surfaces
Authors: Dowgwillo Emily A. , Pincus Aaron L.
Published: April 2016

Recent discussions surrounding the Dark Triad (narcissism, psychopathy, and Machiavellianism) have centered on areas of distinctiveness and overlap. Given that interpersonal dysfunction is a core feature of Dark Triad traits, the current study uses self-report data from 562 undergraduate students to examine the interpersonal characteristics associated with narcissism, psychopathy, and Machiavellianism on four interpersonal circumplex (IPC) surfaces. The distinctiveness of these characteristics was examined using a novel bootstrapping methodology for computing confidence intervals around circumplex structural summary method parameters. Results suggest that Dark Triad traits exhibit distinct structural summary method parameters with narcissism characterized by high dominance, psychopathy characterized by a blend of high dominance and low affiliation, and Machiavellianism characterized by low affiliation on the problems, values, and efficacies IPC surfaces. Additionally, there was some heterogeneity in findings for different measures of psychopathy. Gender differences in structural summary parameters were examined, finding similar parameter values despite mean-level differences in Dark Triad traits. Finally, interpersonal information was integrated across different IPC surfaces to create profiles associated with each Dark Triad trait and to provide a more in-depth portrait of associated interpersonal dynamics.
Development and Examination of the Five-Factor Obsessive-Compulsive Inventory–Short Form
Authors: Griffin Sarah A. , Suzuki Takakuni , Lynam Donald R. , Crego Cristina , Widiger Thomas A. , Miller Joshua D. , Samuel Douglas B.
Published: April 2016

The Five-Factor Obsessive-Compulsive Inventory (FFOCI) is an assessment of obsessive-compulsive personality disorder (OCPD) that is based on the conceptual framework of the five-factor model (FFM) of personality. The FFOCI has 12 subscales that assess those five-factor model facets relevant to the description of OCPD. Research has suggested that the FFOCI scores relate robustly to existing measures of OCPD and relevant scales from general personality inventories. Nonetheless, the FFOCI’s length—120 items—may limit its clinical utility. This study derived a 48-item FFOCI–Short Form (FFOCI-SF) from the original measure using item response theory methods. The FFOCI-SF scales successfully recreated the nomological network of the original measure and improved discriminant validity relative to the long form. These results support the use of the FFOCI-SF as a briefer measure of the lower-order traits associated with OCPD.
Construct Validity of the Violence Risk Scale–Sexual Offender Version Instrument in a Multisite Sample of Treated Sexual Offenders
Authors: Olver Mark E. , Neumann Craig S. , Kingston Drew A. , Nicholaichuk Terry P. , Wong Stephen C. P.
Published: April 2016

The present study examined the construct validity of the Violence Risk Scale–Sexual Offender version (VRS-SO) through an examination of its factor structure and convergence with psychological measures assessing conceptually relevant constructs in a sample of 732 treated incarcerated adult male sex offenders. The VRS-SO was rated prospectively pre- and posttreatment by service providers, and several of the men had completed a psychometric battery at each time point. Prospective Stable 2000 ratings were examined for comparison purposes. Results of exploratory longitudinal factor analysis, performed on VRS-SO pre- and posttreatment dynamic item scores, supported a three-factor model (comparative fit index = .990) and the measurement invariance of the loadings over time. A stringent longitudinal confirmatory factor analysis of the VRS-SO items also supported the three-factor structure. Scores from the three factors (Sexual Deviance, Criminality, and Treatment Responsivity) were correlated in conceptually meaningful ways with scores from the Stable 2000 and selected psychometric measures. The results provide evidence for the construct validity of VRS-SO test scores as providing an index of sex offender risk and, more specifically, that its item content and factor domains measure psychological constructs pertinent to sex offender risk and need.
Cortistatin Improves Cardiac Function After Acute Myocardial Infarction in Rats by Suppressing Myocardial Apoptosis and Endoplasmic Reticulum Stress
Authors: Shi Zhi-Yu , Liu Yue , Dong Li , Zhang Bo , Zhao Meng , Liu Wen-Xiu , Zhang Xin , Yin Xin-Hua
Published: April 2016

Objectives:

The endoplasmic reticulum (ER) stress-induced apoptotic pathway is associated with the development of acute myocardial infarction (AMI). Cortistatin (CST) is a novel bioactive peptide that inhibits apoptosis-related injury. Therefore, we investigated the cardioprotective effects and potential mechanisms of CST in a rat model of AMI.

Methods:

Male Wistar rats were randomly divided into sham, AMI, and AMI + CST groups. Cardiac function and the degree of infarction were evaluated by echocardiography, cardiac troponin I activity, and 2,3,5-triphenyl-2H-tetrazolium chloride staining after 7 days. The expression of CST, ER stress markers, and apoptotic markers was examined using immunohistochemistry and Western blotting.

Results:

Compared to the AMI group, the AMI + CST group exhibited markedly better cardiac function and a lower degree of infarction. Electron microscopy and terminal deoxynucleotidyl transferase dUTP nick end labeling confirmed that myocardial apoptosis occurred after AMI. Cortistatin treatment reduced the expression of caspase 3, cleaved caspase 3, and Bax (proapoptotic proteins) and promoted the expression of Bcl-2 (antiapoptotic protein). In addition, the reduced expression of glucose-regulated protein 94 (GRP94), glucose-regulated protein 78 (GRP78), CCAAT/enhancer-binding proteins homologous protein, and caspase 12 indicated that ER stress and the apoptotic pathway associated with ER stress were suppressed.

Conclusions:

Exogenous CST has a notable cardioprotective effect after AMI in a rat model in that it improves cardiac function by suppressing ER stress and myocardial apoptosis.
Analysis of Heparins Derived From Bovine Tissues and Comparison to Porcine Intestinal Heparins
Authors: St Ange Kalib , Onishi Akihiro , Fu Li , Sun Xiaojun , Lin Lei , Mori Daisuke , Zhang Fuming , Dordick Jonathan S. , Fareed Jawed , Hoppensteadt Debra , Jeske Walter , Linhardt Robert J.
Published: April 2016

Heparin is a widely used clinical anticoagulant. It is also a linear glycosaminoglycan with an average mass between 10 and 20 kDa and is primarily made up of trisulfated disaccharides comprised of 1,4-linked iduronic acid and glucosamine residues containing some glucuronic acid residues. Heparin is biosynthesized in the Golgi of mast cells commonly found in the liver, intestines, and lungs. Pharmaceutical heparin currently used in the United States is primarily extracted from porcine intestines. Other sources of heparin including bovine intestine and bovine lung are being examined as potential substitutes for porcine intestinal heparin. These additional sources are intended to serve to diversify the heparin supply, making this lifesaving drug more secure. The current study examines bovine heparins prepared from both intestines and lung and compares these to porcine intestinal heparin. The structural properties of these heparins are examined using nuclear magnetic resonance, gel permeation chromatography, and disaccharide analysis of heparinase-catalyzed depolymerized heparin. The in vitro functional activities of these heparins have also been determined. The goal of this study is to establish the structural and functional similarities and potential differences between bovine and porcine heparins. Porcine and bovine heparins have structural and compositional similarities and differences.
Pilot study of biological monitoring of four antineoplastic drugs among Canadian healthcare workers
Authors: Poupeau Céline , Tanguay Cynthia , Plante Caroline , Gagné Sébastien , Caron Nicolas , Bussières Jean-François
Published: April 2016

Purpose

There are health risks to workers occupationally exposed to antineoplastic drugs. We hypothesized that implementing a biological monitoring program would be feasible. The goal was to present the results of our pilot cross-sectional study of biological monitoring of four antineoplastic drugs.

Methods

We recruited workers from the hematology–oncology department and control workers in a mother–child university health center. This study was preceded by an information period during which we aimed at enhancing the workers’ awareness and knowledge of the risks of occupational exposure. Participants filled out a journal containing activities performed and personal protective equipment worn. One urine sample was collected at the end of their shift. Samples were analyzed by UPLC/MS-MS for the presence of cyclophosphamide, ifosfamide, methotrexate, and alpha-fluoro-beta-alanine (5-fluorouracile’s main urinary metabolite).

Results

The participation rate was 85.7% (102/119). No urine sample had detectable concentrations of any of the four drugs evaluated (0/101; 0/74 nurses, 0/11 pharmacists, 0/9 pharmacy technicians, and 0/7 doctors). In the 5 days before sampling, 67/92 (72.8%) hematology–oncology participants performed at least one activity with antineoplastic drugs. Nurses wore all of the recommended protection for technical activities (86.2%), but rarely for non-technical activities (14.9%). Pharmacists and pharmacy technicians wore all of the recommended protection for all activities (100.0%).

Conclusions

This pilot study had a good participation rate. The absence of positive samples was a good indication that the measures in place ensured workers’ safety, even though we found areas where the worker protection can be enhanced.
Single 4.5 mg fixed-dose of rasburicase for hyperuricemia associated with tumor lysis syndrome
Authors: Patel Kajal S , Lau Jessica E , Zembillas Anthony S , Gallagher Erika M
Published: April 2016

Rasburicase is a recombinant urate oxidase enzyme administered for treatment of hyperuricemia associated with tumor lysis syndrome. Studies demonstrate effectiveness of single fixed-dose rasburicase as compared to the FDA-approved dose of 0.2 mg/kg intravenously daily for up to five days. Doses in these studies range from 1.5 mg to 7.5 mg. Our study evaluated outcomes in patients who received single 4.5 mg fixed-dose rasburicase. This retrospective, IRB-approved chart review evaluated adult oncology subjects who received fixed-dose rasburicase between January 2007 and April 2014. The primary outcome was percentage of patients with normalization of uric acid (level <8 mg/dL within 24 h) after a single 4.5 mg fixed-dose of rasburicase. Secondary objectives were incidence of initial failure of fixed-dose rasburicase and normalization of uric acid in overweight (body mass index ≥25 kg/m2) versus non-overweight patients. Initial failure was defined as need for additional doses or progression to dialysis within one week of the initial fixed-dose. In the 128 patients included, the mean baseline uric acid level was 14.84 mg/dL. Of the 112 patients with a follow-up uric acid level, 68% achieved normalization within 24 h of rasburicase administration. Thirty-eight patients received additional treatment: 10 received additional dose(s) and 28 underwent dialysis. Normalization of uric acid in overweight versus non-overweight patients was 66% and 73%, respectively.

Overall, a single 4.5 mg fixed-dose of rasburicase effectively normalized uric acid in 68% of patients within 24 h. Further studies are needed to determine the optimal single fixed-dose necessary for treatment response across all patients.