bluuebunny/crossref_metadata_2025 huggingface dataset:
Aron Aleksander Olizarowski i jego sylwetka naukowa w ocenie XIX-wiecznych polskich myślicieli
Authors: Niczyporuk Piotr
Published: April 2023

Dzieło życia Arona Aleksandra Olizarowskiego De politica hominum societate jest częściowo poświęcone kwestii chłopskiej w Polsce XVII w. Zostało ono dostrzeżone w nauce polskiej w XIX w. Ludwik Alojzy Cappelli niewątpliwie znał to dzieło, gdyż prezentował poglądy w nim zawarte w ramach publicznych posiedzeń naukowych Uniwersytetu Wileńskiego w 1817 r. Również Tadeusz Czacki w pracy O litewskich i polskich prawach kilkakrotnie nawiązał do De politica hominum societate i cytował jego obszerny fragment. Zabiegi Czackiego mogą świadczyć o uznaniu doniosłości poglądów Olizarowskiego w kwestii chłopskiej. Również inni polscy uczeni, tacy jak: Feliks Słotwiński, Piotr Chmielowski czy Joachim Lelewel, nawiązywali do dzieła Olizarowskiego, by pokazać jego oryginalny wkład w próbę zreformowania stosunków pańszczyźnianych.
From Crystal-clear to Limpide: Translating English [Noun+adj] Compound Adjectives with a Figurative-intensifying Noun into French
Authors: Prinzie Thomas , Suñer Ferran , Van Goethem Kristel
Published: April 2023

English [Noun+Adj] compound adjectives containing an intensifying metaphor (e.g. crystal-clear) pose particular challenges for French translation, due in part to the absence of a direct equivalent construction. Our study examines morphosyntactic and conceptual-semantic translation procedures that capture how these challenges are resolved. We also explore the little-investigated aspect of translation variation (the number of different solutions for each item). We analyze the potential effects of two factors: the presence or absence of figurative intensification and the items’ frequency of use in English. Our results indicate that translators prefer different morphosyntactic procedures for different compound subtypes. Overall, an adjective constituent is most frequently retained, although complete reformulations with a noun or verb also occur. Semantically, the intensifying meaning is often rendered non-figuratively, depending on what is available in idiomatic French usage. Intensification is also frequently dropped. Translation variation is remarkably high, due in part to extensive use of near-synonyms. High-frequency items do not appear to converge on a smaller number of translations, but instead provide more opportunities for diversification.
Con José María descubrí el Perú quechua actual
Authors: Szyszlo Fernando de
Published: April 2023

Conocí a José María Arguedas en 1944, gracias a mi amistad con Sebastián Salazar Bondy; ocurrió en la librería Crédito y la Editorial Ayza. Inmediatamente, me invitó a la Peña Pancho Fierro, centro de arte popular peruano, donde se exhibía la mejor colección de piezas reunida por Alicia Bustamante, cuñada de José. A través del contacto con José María, los de mi generación descubrimos el Perú quechua actual pues, para nosotros, no existía sino el Perú precolombino.
La irrupción del recuerdo en El zorro de arriba y el zorro de abajo
Authors: Suárez Trejo Javier Teófilo
Published: April 2023

la idea que desarrollaré a lo largo del presente trabajo será la de la violencia arguediana como espacio para la dinámica explosiva del recuerdo y no para la «construcción» de la memoria en El zorro de arriba y el zorro de abajo (o Los zorros). El tema de hoy es polémico, pues toca directa e indirectamente a instituciones tan importantes como la CVR y la memoria «nacional» que se ha pretendido construir, y, sin embargo, creo que su análisis es necesario para abrir espacios en la interpretación de la obra de Arguedas con necesarias implicancias sociales y políticas.
Lo viejo y lo nuevo de los espacios públicos en el Perú
Authors: Patrón Pepi
Published: April 2023

En el libro "El nuevo espacio público" publicado en Francia en 1989 que recopila diversos artículos, Jean-Marc Ferry afirma lo siguiente: "Anunciar el título ambicioso de 'el nuevo espacio público' ya es índice de rechazo: el de una tentación siempre presente de formular un diagnóstico sobre la época actual en términos de un 'déficit', hasta de una decadencia, respecto del ideal, sea clásico, sea moderno, del debate público" 1 . Por ideales clásicos o modernos, se alude por un lado, al viejo modelo griego del ágora y a la importancia de un espacio público político que en su diferencia respecto de la vida privada implicaba una relación dialógica entre ciudadanos iguales entre sí, modelo retomado con mucha fuerza en el pensamiento contemporáneo por una autora como Hannah Arendt, gran teórica del espacio público como espacio de acción concertada y de generación legítima del poder.
Las negociaciones colectivas en Europa y la sociedad de la información
Authors: Slomp Hans
Published: April 2023

Uno de los aspectos más interesantes de esta ciudadanía más activa y esta convergencia, es que se realizan casi sin intervención de la Unión Europea, pero debido a la sociedad de la información. Es el desarrollo de la tecnología más que los cambios en la política supranacional en Europa, lo que causa estas transformaciones radicales en las relaciones laborales y en la ciudadanía europea.
La sociedad de la información, genera mejores condiciones para la negociación?
Authors: Balbi Carmen Rosa
Published: April 2023

Esta pregunta se enmarca en la reflexión sobre algunos temas de la agenda nacional: la consolidación de la democracia, la preocupación por la superación de las exclusiones sociales, por la disminución de lo que vienen siendo una de las resultantes de · la globalización: una creciente desigualdad.
Transnacionalismo y movilidad del capital humano
Authors: Altamirano Teófilo
Published: April 2023

Las dos consecuencias más tangibles que están produciendo las migraciones internacionales son, por un lado, la «fuga» o movilidad del capital humano desde los países emisores hacia los de recepción y, por otro lado, el envió masivo de remesas monetarias y no monetarias desde los países de destino hacia los de origen de la migración. La movilidad del capital humano, llamada por otros «fuga de cerebros», empieza al mismo tiempo en que aparecen las migraciones internacionales; sin embargo, recién en la década de 1960, en el siglo pasado, los británicos utilizaron el término (brain drain) para referirse a la emigración de sus profesionales hacia los Estados Unidos y Canadá como una de las consecuencias de la Segunda Guerra Mundial, que redujo enormemente el empleo de personal altamente calificado.
Una población diferente : cinco décadas de cambio demográfico
Authors: Aramburú Carlos E.
Published: April 2023

En este breve artículo presentamos la dinámica demográfica de la población peruana en las últimas cinco décadas. Los cambios poblacionales son claves para entender la dinámica socioeconómica en cualquier periodo de nuestra historia, pues son a la vez causa y consecuencia de esta. Sin embargo, puede afirmarse que, al igual que el siglo XVI, el siglo XX, en especial la segunda mitad, presenta cambios demográficos que por su magnitud y velocidad son particularmente relevantes para entender las transformaciones sin precedentes que ocurren en la sociedad peruana en los últimos cincuenta años (Aramburú & Bustinza, 2000). Así como el siglo XVI implicó el descalabro demográfico de la sociedad prehispánica como consecuencia de nuevas enfermedades y la desarticulación del Estado inca (Sánchez Albornoz, 1973), el siglo XX estuvo marcado por el signo opuesto: la explosión demográfica y una rápida urbanización.
Líneas de frontera y comportamiento electoral en el Perú. Diferencias sociales y tendencias del voto en las elecciones presidenciales peruanas, 1980-2006
Authors: Sulmont Haak David
Published: April 2023

Entre 1978 y 2006, los peruanos han votado en 28 procesos electorales, ello representaría en promedio una elección por año, de no ser por el hecho de que varias de ellas son simultáneas (presidenciales y parlamentarias; municipales y regionales). Once de esas elecciones fueron presidenciales, contando primeras y segundas vueltas. Como se ha indicado, las preferencias electorales de los peruanos han favorecido a diversos actores en diferentes momentos, desde partidos políticos tradicionales hasta outsiders, con posturas programáticas e ideológicas muy variadas. Muchos analistas coinciden en que la volatilidad electoral en el Perú es una de las más altas de la región andina (Roncagliolo & Meléndez, 2007, p. 403), lo que da cuenta de la fragilidad del sistema de partidos peruano y su bajo nivel de institucionalización. Frente a esta oferta electoral volátil, ¿cuáles son los criterios que toma en cuenta el elector peruano para decidir al momento de votar? Esta es la pregunta central que queremos abordar en este documento.
Movilizaciones sociales y protesta regional : una mirada retrospectiva
Authors: Henríquez Narda
Published: April 2023

Durante varios años, he tenido presente algunas preguntas que han servido de contexto y motivación para el trabajo que he realizado sobre movilizaciones sociales y protesta regional. Se trata de interrogantes sobre qué país tenemos y en qué momento estamos, a las cuales intentaré responder de modo breve aludiendo a los ciclos de larga duración. Luego, me referiré de modo específico a la protesta regional, cambios y tendencias; y, finalmente, presentaré algunas precisiones conceptuales e hipótesis sobre las movilizaciones sociales en el Perú de hoy.
Nuevas élites urbanas en ciudades tradicionales : impactos globales en Cajamarca
Authors: Vega Centeno Sara Lafosse Pablo
Published: April 2023

Durante las últimas décadas, la estructura urbana de las sociedades ha experimentado importantes transformaciones. Los espacios compactos alrededor de actividades industriales han dejado de ser el principal símbolo urbano de prosperidad. Las grandes empresas del nuevo espacio industrial, como lo define Castells (1997), aprovechan las enormes posibilidades de conectividad en tiempo real que ofrecen los actuales medios de comunicación para descomponerse en diferentes unidades, donde cada una de ellas busca localizarse atendiendo las posibles ventajas adicionales, esto es fuera del proceso productivo mismo, que pueda obtener. Este tipo de racionalidad alienta la generación de concentraciones espaciales que funcionan a manera de nodos interconectados entre sí, relativamente independientes del continuo urbano, produciendo un nuevo tipo de lectura de la ciudad, donde el paradigma es la ciudad global (Sassen, 1991) y que Castells define como el espacio de los flujos (1997) y Ascher define como metápolis (1995).
Hacia la equidad de género y la democratización de la familia
Authors: Sara-Lafosse Violeta
Published: April 2023

Mi trayectoria académica incluye la especialización que elegí cuando estudiaba Sociología en la Universidad Católica de Lovaina en Bélgica. En esa ocasión, T. De Bie, el profesor más importante de la especialidad de Sociología, era especialista en familia y codirigió con un profesor visitante norteamericano el Seminario de Sociología que, durante el año, consistió en tomar parte en una investigación comparativa de las familias en Bélgica, en Detroit y en Tokio. Con esa base me puse a trabajar la estructura familiar en el Perú. Por otro lado, el artículo 11 de la Ley General de Educación de 1972, al señalar que «la educación será orientada hacia la revaloración de la mujer, ofreciéndole las máximas oportunidades para un desarrollo personal libre y pleno, única base auténtica de su decisiva función familiar y de su participación creadora en el proceso de transformación y perfeccionamiento de la sociedad peruana», movilizó a toda la sociedad, en especial a los planteles educativos que convocaron masivamente a los padres de familia para debatir con la ayuda de especialistas el significado motivador de la expresión «revaloración de la mujer». Es así como se hizo necesario conocer cuál era el grado de desvaloración de la mujer en el país
Cambio social, religión y secularización : una mirada desde la encuesta mundial de valores
Authors: Romero Catalina
Published: April 2023

Este artículo busca un acercamiento a la pregunta que nos propone Orlando Plaza, el editor de este libro, sobre cómo vemos y entendemos el cambio social desde la experiencia de investigación que tenemos los sociólogos del Departamento de Ciencias Sociales de la Pontificia Universidad Católica del Perú. Esta pregunta me lleva a situar la aproximación que he tomado para este artículo en mi trayectoria de investigación, a manera de introducción para entrar al tema de los cambios en la religión y en los valores medidos a través de la Encuesta Mundial de Valores en América Latina.
Icthyofaunal Diversity of the River Padma at Murshidabad, West Bengal
Authors: Hoque Rabiul , Das Sanjoy , Biswas Poulami , Dey Ananya
Published: April 2023

Background: Fish are considered as bio-indicators of the health of aquatic ecosystems. Recently, native fish species were declining due to anthropogenic pollution and records of fish availability in a specific area of the Padma Riverine System aided in understanding the current status of fish and which fish need conservation. Methods: The fish diversity in Murshidabad district’s Padma River was studied for twelve months, from October 2021 to September 2022, with the help of local fishermen. Freshly caught fish is immediately transported to a laboratory, identification is followed by Talwar and Jhingran (1991) and Rahman (2005) techniques. Result: A total of 49 fish species belonging to 11 orders, 24 families were recorded. Siluriformes (17 species) had the most dominance, followed by cypriniformes (12 species) and anabantiformes. Among the species collected, eight were threatened, thirty were less threatened, one was extremely rare and one had not yet had their status determined. These fishes were classified as threatened (16.33%), less threatened (61.23%) and exceedingly rare (2%). Based on the findings, it is concluded that the Padma River could be used as a refuge for the conservation of Murshidabad’s threatened freshwater fishes.
Tissue Granulation in Cutaneous Wound Healing is Improved by a Camel Milk Peptide in Streptozotocin-induced Diabetes in Rat Models
Authors: Ebaid H. , Al-Tamimi J. , Alhazza I.M. , Metwalli A.
Published: April 2023

Background: Diabetes alters keratinocyte proliferation and tissue granulation during wound healing, thereby delaying the healing process. Thus, we studied the correlation between keratinocyte proliferation and tissue granulation with healing stages and the impact of camel milk peptide (CMP). Methods: Rats were grouped into wounded normal, wounded diabetic and wounded diabetic with daily treatment of CMP at a dose of 100 mg/kg of body weight. One-way ANOVA and Tukey’s method were used to compare the overall effects of each treatment. Result: Diabetes strikingly impaired Protein kinase B (Akt) and Alpha Smooth Muscle Actin (SMA-α) concentrations in the wounded tissues. Furthermore, the gene expression of KGF in wounded tissues was downregulated in diabetic rats. Conversely, CMP showed notable restoration of these parameters. Thus, granulation was enhanced compared with that in non-treated diabetic rats. In addition, the wound margin epithelia of CMP-diabetic rats showed an increase in both size and migration, with two epidermal tongues directed inward and clearly visible on both sides of the wound. However, diabetic rats showed increased extent of wound margin neoepithelia without clear epidermal tongues. These data confirmed the potential role of CMP in wound healing in diabetic rats.
A Typology of the Use of Intimate Partner Psychological Aggression in a Clinical Sample of Men
Authors: Leclerc Marie-Eve , Lafontaine Marie-France , Péloquin Katherine , Brassard Audrey
Published: April 2023

The development of profiles of individuals’ use of intimate partner aggression based on similarities in traits allows for the customization of psychological treatment, which can increase successful therapeutic outcomes and enhance cost-effective practices. Among the existent typologies of partner aggression, none, to our knowledge, has focused on self-reported justification for the specific use of intimate partner psychological aggression (IPPA). Yet, IPPA functions within the context of their justifications. This study aimed to expand on the previously established typologies by proposing a new typology based on the justification for the use of IPPA. A sample of 456 men seeking therapeutic services for their couple’s relationship problems completed a series of questionnaires. A final five-profile solution was obtained using latent profile analyses (i.e., labeled low justification, internal justification, external justification, low malevolence, and high malevolence). The profiles were then compared on diverse IPPA-related variables, further differentiating each profile’s unique combination of characteristics. The profiles range from low to high IPPA severity and present unique patterns of justifications and relational and psychological functioning. A description of each profile and their implications is discussed in the study. Overall, the results emphasize the importance of evaluating justifications in addition to IPPA perpetration and conceptualizing psychological aggression within its context to offer more targeted therapeutic interventions.
Quantifying captures from insect pest trap networks
Authors:   USDA-ARS, USA, Manoukis Nicholas C.
Published: April 2023

In this chapter a high-level overview of the goals of trap networks, some examples and details for tephritid fruit flies, and then a detailed description of the TrapGrid model are given. TrapGrid can be used to quantify the probability of capturing insects instantaneously or over time using a function that relates distance from a given trap to probability of capture and two models of insect dispersal. Brief descriptions of other modeling approaches to these questions, some of which have seen application outside of research, are discussed followed by ideas for the application of TrapGrid, including a way to determine trap attraction (the parameter λ in the model) and how to compare alternative trap layouts on a landscape scale. Finally, in the practicum, a working example was given comparing two alternative trap layouts in a 1 km2 area via quantification of capture probability instantaneously and over 30d.
Advances and challenges in monitoring insect pests of major field crops in the United States
Authors:   Iowa State University, USA, Hodgson Erin W. , Dean Ashley N. ,   Iowa State University, USA, Huseth Anders ,   North Carolina State University, USA, Hutchison William D. ,   University of Minnesota, USA
Published: April 2023

This chapter will review current insect pest monitoring systems for native and invasive pest species of corn, soybean, and cotton in the U.S. We present case studies of European corn borer, corn earworm, western bean cutworm, and corn rootworm as pests of corn; soybean aphid, stink bugs, and Japanese beetle as pests of soybean; and tobacco thrips, plant bugs, and bollworm as pests of cotton. We discuss how new technology has driven recent improvements in monitoring of these pests from the lab, field, and areawide levels. Although the primary emphasis will be the value of pest monitoring to support improved decision-making for IPM programs, we also discuss recent trends and tools for insect resistance management (IRM), since the importance of some field crop pests has increased as resistance continues to evolve.
Saliva Decreases Sucrose-induced Cariogenicity in an Experimental Biological Caries Model
Authors: Giacaman Rodrigo A , Umaña Rodrigo , Nuñez María José , Díaz-Garrido Natalia , Echeverría Constanza , García-Manríquez Natalia , Mira Alex , Fernández Constanza E , Gambetta-Tessini Karla , Lozano Carla P.
Published: April 2023

Objective. Whether a minimum quantity of saliva is needed to inhibit the caries process is unclear. Here, we evaluated the effect of saliva dilutions on an in vitro caries model with Streptococcus mutans (S. mutans) biofilms. Methods. S. mutans biofilms were grown on enamel and root dentin slabs, in culture media containing different proportions of saliva (v/v): 0%, 5%, 10%, 25%, 50%, 75% and 100% saliva, and exposed to a 10% sucrose solution (5 min, 3x/day), with appropriate controls. After 5 (enamel) and 4 (dentin) days, demineralization, biomass, viable bacteria and polysaccharide formation were analyzed. The acidogenicity of the spent media was monitored overtime. Assays were carried out in triplicate in 2 independent experiments (n=6). Results. An inverse relationship was observed between acidogenicity, demineralization, and saliva proportion, both in enamel and dentin. A marked reduction in enamel and dentin demineralization was observed when small amounts of saliva were incorporated in the medium. For both tissues, a significant reduction in biomass, viable S. mutans cells and polysaccharides were observed when saliva was present, in a concentration-dependent manner. Conclusions. High quantities of saliva can almost completely inhibit sucrose-induced cariogenicity, but small amounts can also exert a dose-dependent caries-protective effect.
Computing Nash Equilibria for Multiplayer Symmetric Games Based on Tensor Form
Authors: Liu Qilong , Liao Qingshui
Published: April 2023

In an $m$-person symmetric game, all players are identical and indistinguishable. In this paper, we find that the payoff tensor of the player $k$ in an $m$-person symmetric game is $k$-mode symmetric, and the payoff tensors of two different individuals are the transpose of each other. Furthermore, we reformulate the $m$-person symmetric game as a tensor complementary problem and demonstrate that locating a symmetric Nash equilibrium is equivalent to finding a solution to the resulting tensor complementary problem. Finally, we use the hyperplane projection algorithm to solve the resulting tensor complementary problem, and we present some numerical results to find the symmetric Nash equilibrium.
Impact of Tillage Intensity on the Development of Faba Bean Cultivation
Authors: Kimbirauskienė Rasa , Sinkevičienė Aušra , Jonaitis Rokas , Romaneckas Kęstutis
Published: April 2023

At the time of tillage, properties of the soil change, thereby changing the conditions of crop development and ultimately their productivity and quality. The effect of non-inversion tillage or no till on faba bean development is stills not widely investigated. For this reason, investigations of tillage systems from deep and shallow ploughing, chiselling, disking to no tillage were tested in Vytautas Magnus University, Agriculture Academy, Lithuania. The results showed that different tillage methods had less influence on faba bean development than meteorological conditions during the growing seasons. Soil chiselling generally showed better faba bean canopy development rates than other treatments. Faba bean roots developed somewhat better in not tilled plots. Vegetative conditions had a significant influence on faba bean development indicators. The effects of vegetative conditions during all four years of the experimentation were significantly different from each other. This shows that, due to rapid climate change, the conditions of each vegetative season become unique and require precise attention.
Numerical Simulation on Thermoelectric Cooling of Core Power Devices in Air Conditioning
Authors: Wang Jiang , Hu Kai , Tang Kechen , Xing Yubing , Xiao Yani , Liu Yutian , Yan Yonggao , Yang Dongwang
Published: April 2023

Air conditioners are indispensable necessities in daily life and industrial production. However, the heat generation of their internal core power components can limit their performance release. In this work, we explore the application of thermoelectric coolers (TECs) in the field of power device heat dissipation through finite element simulation. First, we geometrically modeled the structure and typical operating conditions of core power devices in air conditioners. We compared the temperature fields in air cooling and TEC active cooling modes for high power consumption power devices in a 319 K operating environment. The simulation results show that in the single air cooling mode, the maximum temperature of the 173.8 W power device reaches 394.4 K and the average temperature reaches 373.9 K, which exceeds its rated operating temperature of 368.1 K. However, after adding TEC, the maximum temperature of the power device drops to 331.8 K at an operating current of 7.5 A and the average temperature of the device is 326.5 K. It indicates that TEC active cooling has a significant effect on the temperature control of the power device. At the same time, we also studied the effect of TEC working current on the temperature control effect of power devices. For TEC, there is a minimum working current of 5 A; when it is less than 5 A, TEC has no cooling effect; the cooling effect of TEC increases with an increase in working current. When the TEC working current is 10 A, the average temperature of the power device can be reduced to 292.9 K. This study has made a meaningful exploration of the application of TEC in chip temperature control and heat dissipation, providing a new solution for chip thermal management and accurate temperature control.
Anterior Cage Migration during Transforaminal Lumbar Interbody Fusion: A Case Report and Review of the Literature
Authors: Son Yo-Han , Kim Young-Jin , Lee Sang-Koo
Published: April 2023

Transforaminal lumbar interbody fusion (TLIF) is a popular procedure for patients with lumbar instability with unilateral foraminal stenosis. Many complications can occur during the procedure. However, cage migration during the procedure is rarely reported. Anterior cage migrations can lead to catastrophic consequences due to the possibility of major vessel injuries. Here, we present a 76-year-old male patient whose cage extruded anteriorly during L5-S1 TLIF. Fortunately, he did not experience any life-threatening complications, and the migrated cage was visible just below the iliac vessels’ bifurcation site on computed tomography angiography. As an alternative, an emergency anterior lumbar interbody fusion was successfully performed, and the TLIF cage was removed during this procedure.
Contemporary Salt-Marsh Foraminifera from Southern California and Implications for Reconstructing Late Holocene Sea-Level Changes
Authors: Avnaim-Katav Simona , Garrett Ed , Gehrels W. Roland , Brown Lauren N. , Rockwell Thomas K. , Simms Alexander R. , Bentz John Michael , MacDonald Glen M.
Published: April 2023

We report on the distribution of contemporary foraminifera in salt marshes in Mission Bay and Carpinteria Slough, Southern California. Combining these data with existing datasets from Seal Beach and Tijuana, we explore the potential for a regional training set to underpin quantitative reconstructions of paleoenvironmental change from foraminifera preserved in salt-marsh sediments. We demonstrate that species’ distributions are highly dependent on elevation, suggesting fossil foraminiferal assemblages here, as in many other regions, are useful depositional elevation indicators. Transfer functions provide predictions from Mission Bay cores with decimeter-scale uncertainties. Nevertheless, interpretation of marsh-surface elevation change is complicated by a complex geomorphic setting and anthropogenic impacts. An abrupt change in elevation in the mid-1700s may be related to lateral spreading of water-saturated sediments during an earthquake on the Rose Canyon fault, suggesting the potential for foraminifera to support new palaeoseismic and sea-level records for the region.
Plan de negocio para la producción y comercialización de galletas artesanales a base de chirimoya en Lima Metropolitana
Authors:   , Ccope Arrieta Angela Maria , Sanchez Barbarán Lady Luz , Fernandez Chuecha Manuel Augusto
Published: April 2023

La alimentación es uno de los factores claves para el desarrollo de nuestro organismo, ya que de ello dependerá explanar nuestro potencial al máximo, puesto que los nutrientes que ingerimos, pueden repercutir en algunos casos de manera positiva y en otros de manera negativa. Es por esta razón que se ha elaborado un Plan de Negocios para la Industria CHIRIMISKY S.A.C, que consiste en elaborar y comercializar galletas artesanales hechas con pulpa de Chirimoya y harina de avena, endulzada con stevia, los cuales pueden ser consumidos a cualquier hora del día como snack saludable, cuyo objetivo será completar la alimentación de nuestros usuarios de las diferentes edades.Se eligió trabajar con este fruto por sus valores nutricionales, así como por los beneficios que brinda para la salud, tales como: regular la tensión arterial, fortalecer huesos y músculos, combatir la anemia y favorecer en la digestión; por ello lo que se necesita incentivar el consumo de este producto abundante en nuestro país. Actualmente se ha incrementado el sector de alimentos saludables, por ello, esta idea de negocio será un gran aporte económico para aumentar el PBI, por consecuente el crecimiento económico en nuestro país.
Cumplimiento de los objetivos y medidas terapéuticas de la primera hora del shock séptico en Pediatría. Hospital San Bartolomé.2018-2021
Authors:   , Chávez Vargas Rosario Norma
Published: April 2023

Desde muy antaño hasta los tiempos modernos, las enfermedades infecciosas representan un reto para la humanidad. La Organización Mundial de la Salud (OMS) reporta que más del 60% de las muertes en menores de 5 años son a causa de enfermedades infecciosas (6). La sepsis es la falla multiorgánica que puede conllevar a la muerte debido debida a una respuesta incontrolada y desregulada del organismo frente a una noxa infecciosa. Esta respuesta desregulada puede ir desde una manifestación incontrolada y exagerada de la actividad proinflamatoria (p. ej., meningococemia), con una clínica intensa o leve, o la falta de respuesta inflamatoria, como en los pacientes inmunodeprimidos, donde la presentación clínica puede ser silenciosa (por ejemplo, la candidemia relacionada con el catéter venoso central en niños inmunodeprimidos por la quimioterapia) (7). En las últimas décadas, se han realizado campañas y recomendaciones para combatir la sepsis con el fin de facilitar el diagnóstico, promover la intervención temprana y reducir la mortalidad infantil. En consecuencia, se ha producido un notable descenso de la mortalidad por sepsis grave y shock séptico en todo el mundo, con tasas más bajas en los países desarrollados en comparación con las naciones más pobres (19 % frente a 32 %, respectivamente) (8).
Compuestos bioactivos y parámetros de calidad del aceite de palta Hass (Persea americama Mill) procedentes de sistemas convencional y agroforestal orgánico, Lima, Perú
Authors:   , Palacios Sotomayor Carla
Published: April 2023

Ante la carencia de datos científicos que aporten resultados contundentes respecto de las cualidades del aceite de palta orgánico versus el convencional, mediante la presente investigación se evaluaron los compuestos bioactivos y parámetros de calidad de ambos tipos. Para ello, se realizó la extracción mediante el método Soxhlet con solvente (éter de petróleo). Los parámetros de calidad se determinaron mediante las pruebas de Índice de Acidez (A), Índice de Yodo (IY) e Índice de Peróxidos (IP), y la capacidad antioxidante mediante la prueba de 2,2-difenil-1-picrilhidrazilo (DPPH). Obteniendo resultados de A: 0,053% y 0,065%, IY: 43,57 g I2 100 g-1 y 42,07 g I2 100 g-1, IP: 32,70 mEq-g O2Kg-1 y 65,95 mEq-g O2Kg-1 para el aceite de palta orgánico y convencional respectivamente. Los resultados del DPPH fueron expresados como porcentaje de inhibición del radical y 1/EC50, dando valores de 86,90% y 85,66%, y 0,00032 mol DPPH/mol AO y 0,00021 mol DPPH/mol AO, para el aceite de palta orgánica y convencional respectivamente, concluyendo que la calidad del cultivo de palta orgánica es mejor que el de palta convencional, sin embargo, no hay diferencias estadísticamente significativas entre la capacidad antioxidante de ambos cultivos.
Determinación de la presencia de huevos de Ancylostoma spp. en suelo y césped según el estado de conservación de parques no cercados en el distrito de Independencia, Lima
Authors:   , Choton Linares Alberto Andre
Published: April 2023

Las zoonosis parasitarias son de importancia para la salud pública, principalmente por la estrecha relación entre los humanos y sus mascotas; varios tipos de parásitos que infectan a los perros se transmiten a los seres humanos y hoy son una fuente potencial de infección al contaminar los lugares públicos. El objetivo trabajado fue determinar el contagio por huevos de Ancylostoma spp. en la tierra y la hierba en lugares recreativos públicos del distrito de Independencia, y además determinar si existe asociación con el estado de conservación del parque. Se evaluaron 71 parques no cercados en el periodo de mayo a julio del 2017, mediante el método de la doble W con el objetivo de optener 1 kg en cada parque. Las muestras evaluadas fueron tierra y césped tomadas del suelo, que fueron cotejadas mediante la técnica de flotación de Sheather para determinar la presencia de huevos de Ancylostoma spp. en el microscopio. Se presentó la información recolectada de la fase diagnóstica y el cálculo de los huevos de Ancylostoma spp. representándose tablas de frecuencia los resultados con sus respectivos porcentajes aplicando la prueba de cuadrado para establecer la asociación entre la conservación y presencia de los huevos de Ancylostoma spp en los parques. Se obtuvieron 2 parques positivos de los 71 parques no cercados 2.82 % ± 3.85%; hallándose una asociación estadísticamente significativa (p<0.05) entre presencia del parásito y el estado de conservación de los parques.
Evaluación in vitro del efecto bactericida del Piper aduncum "matico" frente a Klebsiella pneumoniae ATCC BAA1706 y Staphylococcus aureus ATCC 25923
Authors:   , Janampa Torres Ricardo Alonso , Loo Guillen Oscar Yu woo
Published: April 2023

Introducción: Las infecciones respiratorias y dermatológicas son una problemática de salud pública y global, siendo Klebsiella pneumoniae y Staphylococcus aureus los agentes etiológicos característicos en sus respectivas categorías infecciosas, el aumento en la resistencia frente al tratamiento convencional genera la búsqueda de una alternativa en los fitofármacos. Entre las alternativas se encuentra el Piper aduncum el cual presenta propiedades de uso medicinal. Objetivo: El estudio busca determinar el efecto bactericida in vitro del Piper aduncum frente a Klebsiella pneumoniae y Staphylococcus aureus, determinar los grupos funcionales químicos y la concentración mínima inhibitoria. Materiales y métodos: Estudio experimental in vitro, prospectivo de tipo longitudinal con extractos hidroalcohólicos de tallos y hojas de Piper aduncum proporcionado por el Instituto Nacional de Salud. Se realizó el ensayo de solubilidad y el screening fitoquímico empleando reactivos específicos, además mediante dilución seriada de las muestras frente a los agentes bacterianos y el uso del método turbidimétrico se determinó la mínima concentración inhibitoria para cada patógeno.
Local Electron Density Regulation of Iron Single Atoms by Adjacent Nitrogen Vacancies for Ultra-stable Photo-Fenton-Like Reactions
Authors: Chen Fei , Sun Yi-Jiao , Yuan Chao-Wei , Bai Chang-Wei , Zhu Ke-An , Chen Xin-Jia , Zhang Bin-Bin , Yang Qi
Published: April 2023

Single-atom catalysts (SACs) have emerged as efficient oxidant activation materials, yielding highly reactive species in organic wastewater decontamination. However, the fundamental studies on single metal sites are susceptible to insufficient electron input and instability. Herein, we first used theoretical calculations to predict the optimal locations of nitrogen vacancy and Fe single-atom sites and also revealed that dual sites could significantly enhance light absorption, charge separation, and transfer. Guided by the computational predictions, introducing adjacent nitrogen vacancies to regulate the electron density of single iron atoms were finely designed and then served as a photo-activator for low-toxic peracetic acid, exhibiting a superior and ultra-stable (15 cycles) activity for eliminating various organic pollutants. The catalytic performance exceeded ~27.4 times that of the original g-C3N4 equivalent over a pH range of 3-9. Electrons trapped in nitrogen vacancies could be rapidly transferred to nearby Fe sites assisted by a visible light switch, accelerating their ability to reduce the "peracetic acid-catalyst" intermediate. Theoretical calculations were further performed to uncover the synergy of dual engines, and the enhanced adsorption and activation of reactive molecules were detected. The electron reduction pathways on the conduction band were sufficiently exposed to produce highly active species, favoring photocatalytic reactions. This work provides insights into the rational design of ultra-efficient and -stable SACs for organic wastewater decontamination in a photo-Fenton-like system.
Wide-Azimuth Seismic Processing Method for Shale Oil Exploration
Authors: Zhang Liyan , Li Ang
Published: April 2023

Continental shale oil has become a major replacement area for increasing oil and gas reserves and production in China. Accelerating the research on exploration and development technology of continental shale oil in China is the key to improving shale oil production. Shale oil reservoirs have strong heterogeneity, it is hard to describe the "sweet spots", and higher imaging accuracy is required as well. Therefore, the use of wide-azimuth seismic data to develop research on shale oil reservoir anisotropy and resolution improvement is the key to improve the shale oil reservoirs imaging. In this paper, taking the Y3 study area in the Qijiagulong sag, Songliao Basin, eastern China as an example, by analyzing the wide-azimuth seismic raw data (including static correction, signal-to-noise ratio, frequency, etc.), the targeted processing technology of wide-azimuth data in the study area is determined. Better imaging results have been achieved, the frequency band of the wide azimuth processing section is 11Hz wider than that of the conventional processing section, and the favorable area of "sweet spot" is comprehensively predicted by using the data after wide-azimuth processing.
CTAB-assisted synthesis of reduced graphene oxide supported Pd nanoparticles(Pd@rGO) as a sustainable heterogeneous catalyst for C-2 arylation of indoles with arylboronic acids.
Authors: GOGOI RAJJYOTI , Borah Geetika
Published: April 2023

A set of Pd nanoclusters embedded in rGO, referred to as Pd@rGO (viz. Pd@rGO0.16, Pd@rGO0.32, Pd@rGO0.48, Pd@rGO1), where subscripts indicate the mmol of cetyltrimethylammonium bromide (CTAB) were synthesized using water as a solvent by simply varying the amount of CTAB that was used to control both morphology and size. TEM analysis indicated that the average particle sizes of Pd@rGO0.16 and Pd@rGO0.32 fall in the range of 4.5-5.0 nm and 20–25 nm, respectively. On the other hand, particles were found to be agglomerated in Pd@rGO0.48 and Pd@rGO1. The Pd@rGO0.16 composite was exhaustively characterized by TEM, SEM-EDAX, powder X-ray diffraction, XPS, and ICP-AES measurements. ICP-AES analysis of Pd@rGO0.16 indicated that 0.01g of Pd@rGO0.16 contains 0.09 mol % Pd. The catalytic potentiality of these NPs was investigated for direct C(sp2)-H bond activation of various indoles with aryl boronic acids. Among the four composites, Pd@rGO0.16 exhibited the best activity for the abovementioned organic transformation. Different indoles with varying electronic groups underwent coupling with aryl boronic acids giving up to 86% product yield. It was retrievable for up to five consecutive catalytic cycles without compromising its catalytic activity.
The results of transperineal versus transrectal prostate extension biopsy: an updated systematic review and meta-analysis
Authors: Dai Jindong , Zeng Yuhao , Wang Minghao , Yang Jiyu , Sun Guangxi , Zhao Jinge , Zhu Sha , Xu Nanwei , Zeng Hong , Zeng Hao , Shen Peng-Fei
Published: April 2023

This systematic review was performed to compare the current understanding of the relative efficacies and complications associated with transperineal (TP) vs. transrectal (TR) prostate biopsy. All clinical controlled trials reporting prostate cancer (PCa) detection rates and complications associated with TP and TR biopsies were systematically identified, including extensive biopsy procedures. A subgroup analysis was performed to assess the impact of certain clinical factors, e.g., prostate-specific antigen (PSA). The pooled analysis for randomized controlled trials (RCTs) combined with comparative case studies (CCSs) showed no difference in the cancer detection rate between TR and TP (risk difference (RD)=-0.01; 95% confidence interval (CI): -0.04–0.02; P = 0.37). There was no significant difference in the cancer detection rate for RCTs (RD=-0.001; 95%CI: -0.006-0.003; P = 0.55) or CCSs (RD=-0.01; 95%CI: -0.05-0.03; P = 0.59). However, more PCa was detected in the subgroup with PSA ≥ 10 ng/ml (RD = 0.07; 95%CI: 0.01–0.13; P = 0.09) and the subgroup with PSA ≥ 20 ng/ml (RD = 0.13; 95%CI: 0.05–0.20; P = 0.001) using TR biopsy across all studies, while this advantage of TR was not found in RCTs alone (RD = 0.13; 95%CI: -0.09-0.35; P = 0.24). And TP detected more PCa in patients with positive mpMRI in MRI-targeted biopsy, with an accuracy rate of 48.5% (205/423) compared to 34.2% (146/427) for the TR route (RD = 0.51; 95%CI: 0.38–0.68; P < 0.01). There was a significantly lower risk of fever (RD = 0.03; 95%CI: 0.01–0.05; P = 0.003) and rectal bleeding (RD = 0.08; 95%CI: 0.01–0.14; P = 0.02) with TP. In conclusion, there was no significant difference in the cancer detection rate between TR and TP, however, TP had advantage over TR in MRI-targeted biopsy; while TP was safer than TR, due to lower risks of fever and rectal bleeding.
Simultaneous quantification of biogenic amines as biomarkers for Parkinson's disease by combining ultraviolet and integrated pulsed amperometric detectors
Authors: Yoon Hae-Jee , Oh Myung Sook , Kwon Ha-Jeong , Hong Seon-Pyo
Published: April 2023

We developed a method combining ultraviolet detection and integrated pulsed amperometric detection for Parkinson's disease diagnosis through the simultaneous quantification of dopamine, 5-hydroxyindolacetic acid, homovanillic acid, serotonin, 3,4-dihydroxyphenylacetic acid, norepinephrine, and epinephrine. All target components were completely separated within 40 min with 5% acetonitrile solution containing 8 mM HClO4 and 0.20 mM − 1-octanesulfonic acid, and showed limits of detection of 0.03–0.10 ng and limits of quantification of 0.10–0.30 ng with linear regression coefficients of 0.9998–1.0000. All inter-day and intra-day precision values were below 9.58%, and the average recoveries were 93.71–109.82% for mouse striatum samples. In a clinical sample application, the levels of the seven components in striatal brain tissue in a mouse model of Parkinson’s disease decreased significantly compared to those of a control group. It was also confirmed via orthogonal partial least squares discriminant analysis that the seven components are useful biomarkers. Our reversed phase–HPLC-UV-IPAD method is expected to be helpful as a simple and economic analytical method for biogenic amines and their metabolites as biomarkers of Parkinson’s disease in clinical and biological labs.
CK-666 protects against ferroptosis and renal ischemia-reperfusion injury through a microfilament-independent mechanism
Authors: Ju Zhenyu , Hu Qian , Sun Wan-Yang , Ou Zexian , Duan Wentao , Qiu Zeyu , Zhao Yanan , Ge Yuanlong , Tang Daolin , Chen Tianfeng , He Rong-Rong , Cheng Xiang , Wu Shu
Published: April 2023

Ferroptosis is a type of regulated cell death caused by iron-dependent accumulation of lipid peroxidation, exhibiting unique morphological changes. Actin microfilaments are crucial for various cellular processes, including morphogenesis, motility, endocytosis, and cell death. However, the role of actin microfilaments in ferroptosis is not well understood. Here, we found that actin microfilaments undergo remodeling and disassembly during ferroptosis. Interestingly, inhibitors targeting actin microfilament remodeling did not impact cell sensitivity to ferroptosis, except for CK-666. Notably, CK-666 attenuated ferroptosis independently of its canonical function of inhibiting the ARP2/3 complex. Further investigation revealed that CK-666 modulates the ferroptosis proteome and prevents lipid degradation during ferroptosis. Liquid chromatography-mass spectrometry analysis and functional assays demonstrated that CK-666 mitigates ferroptosis by directly eliminating lipid peroxidation. Importantly, CK-666 significantly ameliorated renal ischemia-reperfusion injury and ferroptosis in renal tissue. In summary, our findings provide new insights into the relationship between cytoskeleton and ferroptosis, and suggest potential applications of CK-666 in the treatment of ferroptosis-related diseases.
Anthropogenic mineral classification assists resource sustainability
Authors: Zeng Xianlai , Xu Guochang , Li Jinhui
Published: April 2023

A lack of scientific classification and quantification for secondary resources has impeded the systematic and efficient governance of resources. Here, we created an assessment methodology for anthropogenic minerals. Applying it to 42 metals used in 21 types of typical modern products in China, we found the resource gaps between anthropogenic mineral resources (maximum potential) and reserves (accessible amount) were huge. Their ratios were from 23 ± 13–100% in 2021. Today, only 11–17 traditional metals can return to their material streams, and the other 25–31 metals undergo just a single life cycle. In 2021, the total 4.5 ± 1.8 Mt metal loss was worth US$ 8.3 ± 4.2 billion, while the 335 Mt anthropogenic metal stocks were equivalent to about 243 ± 40 Mt potential anthropogenic mineral reserves. New data and insights provided by this innovative methodology can break through current urban mining barriers, assisting in decoupling economic growth from resource depletion and environmental degradation.
Deep computational microscopy via physics-informed end-to-end learning with a learned forward model
Authors: Lee Seung Ah , Kim Hyeongyu , Kim Kyungwon , Lee Kyung Chul , Lee Kyungwon , Eo Taejoon , Jun Yohan , Hwang Dosik
Published: April 2023

Computational microscopy, which merges cutting-edge optical methods with intricate algorithms, offers significant potential for applications such as resolution improvement and quantitative phase retrieval. However, it faces challenges due to high computational demands and the need for precise algorithms. Recent advancements in data-driven deep-learning-based techniques have emerged to mitigate these challenges; however, incorporating physics-based constraints can further address the limitations. In this paper, we propose a deep-learning framework for image reconstruction in computational microscopy that combines the advantages of single-pass, end-to-end inversion and physics-informed learning approaches, while considering the challenges in obtaining exact physics-informed constraints. Our network learns the forward imaging process, which accurately estimates position-dependent optical aberrations and serves as an effective physical prior in the training of the reconstruction model. Validated on Fourier Ptychography (FP), our proposed framework demonstrates fast and robust FP reconstructions that outperform conventional model-based methods with significantly fewer input measurements and exhibits generalizability to unseen samples, as demonstrated by quantitative comparisons with existing methods. We evaluated our approach on various datasets, including human breast cancer pathology samples, the HeLA dataset, and the USAF phase target dataset, demonstrating that our method improves the practicality of computational microscopy by offering high-quality reconstructions with faster speeds over different sample types.