bluuebunny/crossref_metadata_2025 huggingface dataset:
COĞRAFİ KEŞIFLER KONUSUNUN ÖĞRETILMESINE İLİŞKİN ÖĞRETMEN GÖRÜŞLERİ
Authors: CENGİZ Meryem , ÖZTÜRK DEMİRBAŞ Çağrı
Published: October 2022

Dünyanın bilinmeyen noktalarının keşfi coğrafi keşiflerin temelini oluşturmuştur. Ortaokul sosyal bilgiler 7. sınıf ders kitaplarındaki coğrafi keşifler çalışmanın konusunun öğretilmesine yönelik öğretmen görüşlerini belirlemeyi amaçlayan bu çalışma nitel bir çalışmadır. Sosyal bilgiler 7. Sınıf dersini okutan öğretmenlere yarı yapılandırılmış görüşme formu uygulanmıştır. Nitel araştırma desenlerinden olgubilim kullanılmıştır. Araştırmada sosyal bilgiler öğretmenlerinin coğrafi keşifler konusunun öğretilmesiyle ilgili konunun gerekliliği, öğrenme öğretme süreci, karşılaşılan sorunlar ve konunun ders kitabındaki anlatımına yönelik görüşleri ele alınmıştır. Öğretmenler konunun öğretilmesini gerekli, önemli bulmuş ve dersin amaçlarına katkısı olduğunu düşünmektedir. Öğrenme sürecinde öğretmenler konuya giriş yaparken en fazla soru cevap, dersi anlatırken ağırlıklı olarak düz anlatım kullanmış ve materyal olarak en fazla harita kullanmışlardır. Konuya verilen süre öğretmenler tarafından yetersiz bulunmuştur. Öğretmenler daha çok öğrenci kaynaklı sorunlar yaşamaktadır. Öğrencilerde oluşan kavram yanılgılarını da ağırlıklı olarak açıklama yaparak giderdikleri sonucuna ulaşılmıştır.
Hangover-Related Internet Searches Before and During the COVID-19 Pandemic in England: Observational Study
Authors: Robinson Eric , Jones Andrew
Published: October 2022

Background

It is unclear whether heavy alcohol use and associated hangover symptoms changed as a result of the COVID-19 pandemic. Due to a lack of available accurate and nonretrospective self-reported data, it is difficult to directly assess hangover symptoms during the COVID-19 pandemic.

Objective

This study aimed to examine whether alcohol-induced hangover-related internet searches (eg, “how to cure a hangover?”) increased, decreased, or remained the same in England before versus during the COVID-19 pandemic (2020-2021) and during periods of national lockdown. Secondary aims were to examine if hangover-related internet searches in England differed compared to a country that did not impose similar COVID-19 lockdown restrictions.

Methods

Using historical data from Google Trends for England, we compared the relative search volume (RSV) of hangover-related searches in the years before (2016-2019) versus during the COVID-19 pandemic (2020-2021), as well as in periods of national lockdown versus the same periods in 2016-2019. We also compared the RSV of hangover-related searches during the same time frames in a European country that did not introduce national COVID-19 lockdowns at the beginning of the pandemic (Sweden). Hangover-related search terms were identified through consultation with a panel of alcohol researchers and a sample from the general public. Statistical analyses were preregistered prior to data collection.

Results

There was no overall significant difference in the RSV of hangover-related terms in England during 2016-2019 versus 2020-2021 (P=.10; robust d=0.02, 95% CI 0.00-0.03). However, during national lockdowns, searches for hangover-related terms were lower, particularly during the first national lockdown in England (P<.001; d=.19, 95% CI 0.16-0.24; a 44% relative decrease). In a comparison country that did not introduce a national lockdown in the early stages of the pandemic (Sweden), there was no significant decrease in hangover-related searches during the same time period (P=.06). However, across both England and Sweden, during later periods of COVID-19 restrictions in 2020 and 2021, the RSV of hangover-related terms was lower than that in the same periods during 2016-2019. Exploratory analyses revealed that national monthly variation in alcohol sales both before and during the COVID-19 pandemic were positively correlated with the frequency of hangover-related searches, suggesting that changes in hangover-related searches may act as a proxy for changes in alcohol consumption.

Conclusions

Hangover-related internet searches did not differ before versus during the COVID-19 pandemic in England but did reduce during periods of national lockdown. Further research is required to confirm how changes in hangover-related search volume relate to heavy episodic alcohol use.

Trial Registration

Open Science Framework 2Y86E; https://osf.io/2Y86E
Exploring Stakeholder Requirements to Enable the Research and Development of Artificial Intelligence Algorithms in a Hospital-Based Generic Infrastructure: Protocol for a Multistep Mixed Methods Study
Authors: Weinert Lina , Klass Maximilian , Schneider Gerd , Heinze Oliver
Published: October 2022

Background

In recent years, research and developments in advancing artificial intelligence (AI) in health care and medicine have increased. High expectations surround the use of AI technologies, such as improvements for diagnosis and increases in the quality of care with reductions in health care costs. The successful development and testing of new AI algorithms require large amounts of high-quality data. Academic hospitals could provide the data needed for AI development, but granting legal, controlled, and regulated access to these data for developers and researchers is difficult. Therefore, the German Federal Ministry of Health supports the Protected Artificial Intelligence Innovation Environment for Patient-Oriented Digital Health Solutions for Developing, Testing, and Evidence-Based Evaluation of Clinical Value (pAItient) project, aiming to install the AI Innovation Environment at the Heidelberg University Hospital in Germany. The AI Innovation Environment was designed as a proof-of-concept extension of the already existing Medical Data Integration Center. It will establish a process to support every step of developing and testing AI-based technologies.

Objective

The first part of the pAItient project, as presented in this research protocol, aims to explore stakeholders’ requirements for developing AI in partnership with an academic hospital and granting AI experts access to anonymized personal health data.

Methods

We planned a multistep mixed methods approach. In the first step, researchers and employees from stakeholder organizations were invited to participate in semistructured interviews. In the following step, questionnaires were developed based on the participants’ answers and distributed among the stakeholders’ organizations to quantify qualitative findings and discover important aspects that were not mentioned by the interviewees. The questionnaires will be analyzed descriptively. In addition, patients and physicians were interviewed as well. No survey questionnaires were developed for this second group of participants. The study was approved by the Ethics Committee of the Heidelberg University Hospital (approval number: S-241/2021).

Results

Data collection concluded in summer 2022. Data analysis is planned to start in fall 2022. We plan to publish the results in winter 2022 to 2023.

Conclusions

The results of our study will help in shaping the AI Innovation Environment at our academic hospital according to stakeholder requirements. With this approach, in turn, we aim to shape an AI environment that is effective and is deemed acceptable by all parties.

International Registered Report Identifier (IRRID)

DERR1-10.2196/42208
Сарт-калмаки Пржевальского уезда Семиреченской области в начале XX в.
Authors:   Al-Farabi Kazakh National University (71, Al-Farabi Ave., 050040 Almaty, Republic of Kazakhstan), Miymanbaeva Fialka N. , Abdiraiymova Ardak S. , Aitkazina Mira M. ,   Academy of Logistics and Transport (97, Shevchenko St., 050012 Almaty, Republic of Kazakhstan)
Published: October 2022

Introduction. Economic conditions to have experienced by the Issyk-Kul Sart Kalmyks of Semirechenskaya Oblast in the early 20th century remain uninvestigated in historical literature, which makes the study relevant enough. Goals. The work aims to consider the traditional Sart Kalmyk system of farming, define its type, and analyze the transition to settled life. Materials and methods. The study employs both general scientific and specific historical research methods, including that of statistical analysis. The work examines materials from Russia’s central archives, as well as statistical survey data on economic and land use practices of the Kyrgyz — including households of Sart Kalmyks — and Russian old-timers collected in Przhevalsky Uyezd (Semirechenskaya Oblast) under the guidance of P. P. Rumyantsev in 1913. Analysis of statistical materials yields a reconstruction of the Sart Kalmyk economy in the early 20th century and determines its type. Results. The Sart Kalmyks to have inhabited several localities around Karakol in Issyk-Kul (Przhevalsky) Uyezd were engaged in livestock breeding and, in part, crop farming, i.e. were following their traditional economic practices. Conclusions. However, by the beginning of the 20th century the Sart Kalmyks no longer possessed sufficient pastures and livestock to specialize in breeding only, and were forced to tackle arable farming too, though the latter played no crucial role in their economy remaining an auxiliary sector. The lack of arable land and hayfields forced the Sart Kalmyks to engage in additional occupational activities. So, the population was characterized by a semi-sedentary type of farming, i.e. the period witnessed a change in the Sart Kalmyks’ economic system proper and respective conditions at large.
A Longitudinal Analysis of the Life Satisfaction of Young People in Multicultural Families and the Stress of Mother's Daily Life and Cultural Adaptation
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Hye-Gum
Published: October 2022

Objectives The purpose of this study is to longitudinally examine the changes in the life satisfaction of adolescents from multicultural families and the mother's acculturation stress according to the change of time, and the change in the relationship between adolescents' life satisfaction and mother's daily life stress. Methods For this purpose, data from the 4th and 6th years (2014-2016) were used among the multicultural youth panel survey data of the Korea Youth Policy Institute. The subjects of this study were 1,625 mothers from multicultural families and 1,635 adolescent children from 1st to 3rd grade of middle school. Results The research results are as follows. First, it was found that the life satisfaction of adolescents from multicultural families and the mother's acculturation stress gradually decreased as the children progressed from the first to the third year of middle school, and the mother's daily life stress gradually increased. Second, the higher the life satisfaction of children of multicultural families during the first year of middle school, the lower the daily life stress and acculturation stress of foreign mothers measured at the same time. In addition, the rate of change in life satisfaction among adolescents from multicultural families during the first to third year of middle school had a negative effect on the rate of change in mother's daily life stress. Third, it was found that the mother's initial value of acculturation stress plays a partial mediating role in the relationship between the initial value of life satisfaction of adolescents from multicultural families, and the mother's initial value of daily life stress and the rate of change of daily life stress. Conclusions The results of this study have policy implications that social measures should be devised to enable multicultural families to settle healthily in Korean society.
Developing Middle School Technology Education Teaching Aids and Equipment Standards
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Na Da-ye , Yoon Ji-a , Kim Ki-soo
Published: October 2022

Objectives The purpose of this study is to provide basic data for the operation and activation of effective technical curriculum education in the school field by developing middle school technical curriculum teaching tools and facilities standards for future technical education. Methods To this end, the basic direction of the study was derived through analysis of the technical curriculum, consideration of the future education paradigm, prior research related to the technical lab, and literature analysis. Through the analysis of 12 kinds of technology and home textbooks and the analysis of teaching aids and facilities standards of 17 metropolitan and provincial offices of education, the theoretical basis for the development of teaching aids and facilities standards for middle school technology subjects was established. To this end, the FGI Expert Council, two FGI surveys, and validity verification using CVR values were conducted. Results Through the FGI Expert Council consisting of 10 technical education and engineering education experts, we discussed classification of areas of teaching and equipment standards, importance of safety-related teaching tools and facilities, textbook analysis, and modernized technology room case studies. The developed draft conducted a Delphi survey of 20 technical education experts to verify the validity. For each item of the draft parish and facility standards, the validity average, standard deviation, consensus and convergence, and CVR values were analyzed, and the final version of the middle school technical curriculum was developed by reflecting expert opinions. Conclusions First, the standards for teaching aids and facilities of technical subjects need to be revised according to the revision of curriculum and textbooks in the same way as other subjects (science, physical education, early childhood, special, etc.). Second, it is necessary to flexibly apply it according to the size and characteristics of the school, referring to the specifications, required standards, and essential/recommended conditions along with the items in the notice of teaching aids and facilities of the metropolitan and provincial offices of education. Third, since this study developed the minimum parish and facility standards for conducting practical activities, unit schools need to have parish tools and facilities other than the suggested standards as necessary.
Changes in Communication Skill, Empathy, and Acceptance of others through a Habruta-based Class: Focusing on college students majoring in counseling psychology
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Ji-hye
Published: October 2022

Objectives This study determined whether a Havruta based class would bring about a positive effect on communication skills, empathy, and acceptance of others to college students majoring in counseling psychology. Methods For this purpose, Havruta was applied for 12 weeks out of 15 weeks for 42 participating students. To analyze the effectiveness of the Havruta class, a response sample t-test was conducted to identify changes in communication skills, empathy, and acceptance of others. Results As a result of conducting the  major class for college students majoring in counseling psychology as a Habruta-based class for 12 weeks, the communication ability, empathy ability, and acceptance of others were statistically higher after class participation than before class participation. In other words a Havruta-based class were found to have a positive effect on the communication skills(verbal and nonverbal communication), empathy(cognitive empathy), and acceptance of others. Conclusions Based on these results, this study confirmed the possibility of a Havruta based class as a way for those studying counseling psychology to enhance communication skills, empathy, and being more accepting of others in an effective manner.
Influencing Factors of Career Barriers Perceived by High School Students from Multicultural Families: A Study Using the Smart PLS-SEM Approach
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Donguk
Published: October 2022

Objectives This study was conducted to investigate the factors influencing perceived career barriers of high school-age multicultural adolescents. The detailed goals are 1) the relationship between parental support, friend relationship, teacher relationship and self-esteem, 2) the relationship between parental support, friend relationship, teacher relationship and career barriers perceived, and 3) self-esteem and career barriers perceived. Methods The general characteristics of the subjects were analyzed using SPSS 28.0 for 1,146 multicultural adolescents in their third year of high school, which is the 9th waves of the Multicultural Adolescents Panel Study. Structural equation modeling analysis (PLS-SEM) based on partial least squares (PLS) was used. For model evaluation of PLS-SEM, internal consistency reliability, convergent validity and discriminant validity were checked. For structural model evaluation and hypothesis testing, multicollinearity (VIF), adjusted R2, effect size (f2), predictive relevance (Q2), and statistical significance were checked. Results First, although parental support did not have a direct effect on career barrier perception, it showed an indirect effect on career barrier perception by using self-esteem as a mediating effect. Second, friend relationship had a direct negative effect on career barrier perception, and showed an indirect effect on career barrier perception with self-esteem as a mediating effect. Third, teacher relationship did not have a direct effect on career barrier perception, but showed an indirect effect on career barrier perception using self-esteem as a mediating effect. Conclusions Through the results of the study, it was confirmed that self-esteem had a mediating effect on the relationship between parental, friend, teacher relationship and career barrier perception, and parental, friend, and teacher relationship all showed a significant positive effect on self-esteem.
A Study on Factors in School Activities Affecting the Ratio of Low Performing Students in Middle Schools
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Munkbayaraa Tsogtbaatar , Lee Giwon , Jang Seonhee , Chung Jae Young
Published: October 2022

Objectives The purpose of this study is to analyze the factors of school education activities that affect the percentage of low performing students in middle schools and suggested significant implications for improving school education activities. Methods Multiple regression model was used to find out what school factors affect the proportion of middle school students who low performing in each subject of Korean, English, and mathematics. Accordingly, the ratio of low performing students in Korean, English, and mathematics subjects was used as a dependent variable. Factors related to school characteristics were included as control variables. An analysis was conducted by setting the variables of school education activities as independent variables. Results As a result of the study, the factors of school characteristics that have a significant effect on the ratio of low performing students in Korean, English, and math subjects were found to be the type of establishment, the ratio of students supporting lunch expenses, and the implementation of English education programs. In the case where the type of school establishment is national and public compared to private schools, the higher the proportion of students supporting meal expenses, the higher the ratio of low performing students. It was found that schools that implement English education programs had a lower rate of low performing studensts compared to schools that did not implement them. In addition, the variables ‘the number of books borrowed per student’ and ‘grouping by ability’ were found to reduce the rate of low performing students in English and math subjects. Conclusions The educational policy implications to reduce the the ratio of low performing students in middle school in Korean, English, and mathematics subjects are as follows: It is necessary to prepare measures to promote reading activities and reading education, operate personalized school education activities reflecting student ability, and monitoring of the operation of after-school programs.
Auto-Ethnography of Post-Management Service Experiences for Graduates from a Teacher in special-education school
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jung Jin-sic
Published: October 2022

Objectives This study aims to investigate post-management service experiences for graduates among teachers in a post-secondary program for vocational education in an auto-ethnographic inquiry, thus examining their post-management service experiences from multiple angles and searching for plans to vitalize their post-management service. Methods For these purposes, the study made an auto-ethnographic approach. Auto-ethnography is a methodology for researchers to look at their experiences in a first-person narrator and observer to understand their social and cultural contexts. I collected personal internal data, interview data, participation observation data, and local data in order to explore the post-management service. The data were interpreted through the process of the comprehensively analytical procedure based on the practical eclecticism. This study tried to reflect on meaning of the post-management service from the perspectives of a teacher as an insider. Results First, the subjects reflected on problems with their post-management service provided only in documents and had a self-examination into the need for post-management service for graduates; secondly, they felt their limitations with the improvement of the post-management service system, but they managed to establish a post-management service environment that was realistically feasible and search for ways to make a cooperative approach with concerned agencies; and finally, they took into consideration what kind of talents that corporations wanted and practiced individualized post-management service reflecting students' individual needs. Conclusions The investigator felt a need to continue post-management service for the successful job retention of graduates as a teacher in a post-secondary program for vocational education. There should be efforts to prepare guidelines at the level of municipal and provincial education offices, have regular discussions about post-management service in a consultative group of concerned agencies, and expand the scope of post-management service throughout life so that post-management service can be vitalized.
The Russian project of social epistemology: critical considerations
Authors:   RAS Institute of Philosophy, Kasavin Ilya
Published: October 2022

ntroduction and purpose. The paper is a reaction to the article previously published in this journal by A. M. Orekhov, which examines the state of affairs in Russian social epistemology. The author provides responses to critical comments and proposes clari- fication of the facts and theories discussed. Methods. The author of the article uses the meth- od of conceptual analysis and historical narrative. Scientific novelty of the study. It is shown in a new way how Russian social epistemology fits into the world philosophical context; its conceptual and methodological status is clarified, the details of its formation and development over the past thirty years are revealed. Its features are indicated, mak- ing it possible to rank it as a non-classical episte- mology. Results. The author proposes arguments against a critical assessment of the current state of Russian social epistemology in terms of its dependence on Western influences. It is argued that Russian phi- losophy cannot and should not completely get rid of dependencies, since it borders on isolationism. A critical assessment of the KHM style is given, which has been proposed by A. M. Orekhov as a perspective of social epistemology.
Existential approach to studying the existence of the digital generation
Authors:   South Ural State Humanitarian Pedagogical University, Bogdanova Veronika
Published: October 2022

The article examines the existence of the digital generation from the viewpoint of the existential approach. The author shows that digital technolo- gies expand a person’s connection with reality; he goes beyond his own physicality and overcomes spatial and temporal boundaries. Virtuality begins to be perceived as a continuation of reality, there- fore being-in-the-world is defined by the author as a “hybrid being”, which is a synthesis of virtual and everyday life of the subject. In the article, the author concludes that the blurring of the bound- ary between the real and the virtual actualizes the need of the individual for self-determination and self-creation, which are realized in being-with- another. Digital culture leads to the transformation of being-with-another, because in the virtual world the other is absent in his physicality, which makes it possible to hide the identity by creating digital pres- entations. The construction of virtual images allows the subjects to manifest different sides of the multifaceted “I” and overcome social categorization, which makes the communication process deeper in an existential sense.
Philosophical discussions with children: problems and prospects
Authors:   National Academy of Sciences of Belarus, Doronina Svetlana
Published: October 2022

Introduction. The article presents the results of the philosophical discussion with high school students, considers the problems and prospects for conducting classes in philosophy with children, and proposes original teaching methods that repre- sent a synthesis of philosophical, pedagogical and research approaches. The purpose of the article is to demonstrate the relevance of the ideas, methods and approaches of philosophy with children in the context of modern philosophical, pedagogical and research problems. Research methods are based on the theoretical principles of hermeneutic-phenomenological and psychoanalytic approaches to the interpretation and structural-semiotic analysis of linguistic state- ments. The scientific novelty of the research lies in devel- oping the author’s approach to holding philosophi- cal discussions with schoolchildren, which carries out the synthesis of philosophical-pedagogical and research teaching methods. Results and conclusions. As a result of the study, a conclusion is made about the relevance and demand for such classes of philosophy with children related to interdisciplinary trajectories of its development, the search for effective teaching strategies focused on the comprehensive develop- ment of children and their involvement in research activities.
Social policy and paternalism in the traditionalistic political philosophy of 17th century France
Authors:   RAS Institute of philosophy, Podolskiy Vadim
Published: October 2022

Introduction. Discussions on social policy in French traditionalism of the XVII century served as a source for philosophic considerations in the XVIII century, and defined the features of the French conservatism in the XIX century and specif- ics of the French welfare state in the XX century. The purpose of the article is to review the attitude of the French traditionalists of the XVII century on the social policy. Methods. The article relies on historic and com- parative approach and analysis of institutions and shows the features of the political philosophy in France of the XVII century within the context of the social and political problems and religious polemics. Scientific novelty of the study. The article offers analysis of the social policy conceptions of the French traditionalistic philosophy of the XVII century and highlights in paternalistic feudal- ism the background for the development of the conservative philosophy and social policy. Results. Two main approaches coexisted within the French traditionalism of the XVII century: support of the traditional role of the aristocracy and advocacy of the strong monarchy. Both approaches held paternalistic views and believed that it was neces- sary for the strong to display responsibility for the well-being of the weak, they supported aid for the needy to preserve the social order and to for their education. Conclusions. Reflections of the French traditional- ists of the XVII influenced the development of the unique structure of the welfare state in France, defined by the principle of solidarity, and coexist- ence of many different actors, with strong role of the state.
Food comes in bites: mammalian dietary space in terms of food items, nutrition and energy
Authors: Lintulaakso Kari , Tatti Nikolaj , Žliobaitė Indrė
Published: October 2022

The accepted ORIGINAL ARTICLE is published in Mammalian
Biology:

https://doi.org/10.1007/s42991-022-00323-6

Lintulaakso, K., Tatti, N. and Žliobaitė, I., 2022. Quantifying
mammalian diets. Mammalian Biology, pp.1-15.

This preprint differs from the accepted version by leaving out the
energy contents of the mammalian diets.

Below is the abstract from the accepted manuscript:

We propose a quantitative approach for categorising mammalian diets
based on the taxonomy of food items and parts consumed (the form of
food). Our analysis covers 82% of the mammalian species alive today.
The diet information comes from different data sources—textbooks,
datasets and peer-reviewed literature and includes a transformation of
narrative quantitative data into qualitative data. We link a database on
nutrient composition of diet items of the quantitative diet data and
analyse the distribution of macronutrients of diets across taxonomic
groups and map them to the dental morphology of the eaters. The results
show associations between dental complexity and the concentrations of
some nutrients. Our analysis highlights omnivory as a multi-faceted
concept—there are many kinds of omnivores within the dietary space we
report. The developed dataset and the proposed approach relating the
chemical composition of diets offers a basis for future comparative
studies of living and fossil mammals. With this study, we make the
accompanying large-scale dietary data publicly available online
(https://www.mammalbase.net).
Altered states of Ganzfeld: A systematic review
Authors: Roy Anney
Published: October 2022

The Ganzfeld experiment appears as a uniform and unstructured field that
may measure altered states of consciousness. The experiment uses a dim
light frequency projected on translucent eye covers combined with a
static audio frequency emitted through a pair of headphones. Since
altered states and alpha interactions appear in Ganzfeld studies, the
hypothesis here states that they may be internally related. Therefore,
the extraction filtered EEG data from combined stimulations of light and
static sound for their implications on consciousness. The systematic
search included PubMed, Scopus, Medline (OVID), and the Web of Science
databases to gather data. Between January 2000 and January 2022, only
four controlled trials studied the Ganzfeld-EEG stimulation. The results
verify the role of alpha interactions during hallucination-like imagery.
Furthermore, this review highlights a significant gap in
Ganzfeld-induced altered states of consciousness research.
Congenital cytomegalovirus infection: features of the clinical course and catamnesis according to own observations
Authors: Antsiferova E. V. , Taranushenko T. E. , Geninova D. G. , Karpova L. N. , Filippova L. A. , Karaganova K. I. , Karpova L. S.
Published: October 2022

Congenital cytomegalovirus infection is the most common congenital infection, occurs in 0.6-5% of newborns worldwide, and is considered the leading non-genetic cause of sensorineural hearing loss in children. Most newborns with a manifest form of the disease develop psychomotor and cognitive disorders, and about half of them develop visual impairment.

The purpose of publication: to present a clinical case of severe congenital cytomegalovirus infection in the manifest period with multisystem manifestations (hemorrhagic syndrome, encephalitis, myocarditis, hepatitis, splenomegaly) and follow-up data at the age of 1 year.

Conclusion. this clinical example demonstrates diagnostic and therapeutic difficulties in the acute period of the disease and a significant list of diseases resulting from infection. Based on the information presented, the importance and necessity of close attention to the results of a serological study of pregnant women during the entire gestation period with an assessment of the antibody titer to cytomegalovirus infection in dynamics are updated. Specific antiviral therapy, prescribed on the basis of a life-threatening course of a severe manifest form of the disease, made it possible to achieve positive dynamics in the acute period, eradicate the virus and prevent severe outcomes, including death.
Clinic and diagnosis of encephalopathy of critical conditions in children with infectious diseases
Authors: Egorova E. S. , Klimkin A. V. , Vilnits A. A. , Skripchenko N. V. , Voitenkov V. B. , Vasilyeva Yu. P. , Bedova M. A.
Published: October 2022

Purpose: to assess the functional state of the brain in critically ill encephalopathy in children with infectious diseases.

Materials and methods: 75 patients aged from 1 month to 17 years 11 months with infectious diseases, who were in the intensive care unit of the clinic, were examined, divided into two groups: the main group and the comparison group. Exclusion criteria: patients with cerebral palsy, organic lesions of the central nervous system, neuroinfections and epilepsy. Conducted daily clinical and neurological examination; study of the level of neurospecific proteins (NSE, protein S100) in blood serum; electroencephalography; study of evoked potentials of various modalities; ultrasound examination of the optic nerves, neuroimaging.

Results: All patients had general infectious manifestations, the development of sepsis syndrome, cerebral systemic disorders with impaired consciousness, as well as convulsive syndrome. In the acute period of the disease in the main group, NSE values in 87.5% of children were within the upper limit of normal, S100 protein levels were many times higher than those in the comparison group. In dynamics, all patients showed an increase in the level of NSE, which correlated with persistent neurological symptoms in the form of irritability, weakness, and cognitive decline. In the comparison group, an increase in NSE occurred in 53% of children, an increase in S100 - in 83%. By the time of discharge, 47% of patients had an increase NSE and S100 protein. Visual evoked potentials in 84% of the children of the main group in the acute period, had a decrease the amplitude of the N2-P2 cortical response was revealed without significant dynamics in the future, which was accompanied by pronounced clinical manifestations, which made it possible to substantiate the expediency of dispensary observation of children who underwent a critical condition against the background of severe infectious pathology.

Conclusion: in infectious diseases in children that are not accompanied by inflammatory processes in the nervous system, but proceed with the development of a critical condition, there is a neuropsychiatric deficit in the outcomes, which necessitates follow-up follow-up of such patients in the future.
Clinical and etiological characteristics of pneumonia in children with a poor outcome of infectious diseases
Authors: Kozyrev E. A. , Babachenko I. V. , Karev V. E. , Pimenov D. A. , Sharipova E. V. , Orlova E. D. , Tian N. S.
Published: October 2022

Purpose: to study the clinical and etiological features of pneumonia in children with a poor outcome of infectious diseases.

Materials and methods. The retrospective analysis of clinical, anamnestic, laboratory, instrumental data of 46 children who died from infectious diseases during the period from December 2009 to November 2019 was carried out, of which 26 patients had pneumonia at autopsy. The etiology of pneumonia was determined in vivo and postmortem using cultural, molecular genetic, serological methods and immunohistocytochemical examination of lung tissue. Pneumonia was classified into primary and secondary.

Results. In patients with pneumonia in the structure of generalized infections (n=26) secondary forms prevailed (septic – 14 cases, ventilator-associated (VAP) – 5, aspiration – 2); primary pneumonia was detected in 5 children. Clinical polymorphism and frequent absence of typical symptoms of pneumonia (cough, shortness of breath, auscultatory and percussion changes) were shown, that led to intravital underdiagnosis of pneumonia in 31% of patients. The probable etiology of pneumonia was detected in vivo and postmortem in 58% and 98% of cases respectively. S. pneumoniae (40%) and H. influenzae type b (40%) were main pathogens in primary pneumonia, N. meningitidis (36%) and S. pneumoniae (29%) – in septic pneumonia, commensals of naso- and oropharynx (S. salivarius) – in aspiration pneumonia, nosocomial bacteria (S. aureus and coagulase-negative staphylococci) – in VAP. In children with HIV infection, pneumonia was associated with opportunistic pathogens (P. jirovecii, C. neoformans). In 87% of cases polymicrobial associations were found in lower airways, that makes it difficult to identify the main causative agent of pneumonia.

Conclusions. Most of symptoms of pediatric pneumonia in the structure of generalized infections are nonspecific. Post-mortem study improves the etiological verification of pneumonia and allow to suggest the most pathogenetically and thanatogenetically significant pathogen.
Aspects of cytomegalovirus reactivation in critically ill patients
Authors: Gorbachev V. V. , Dmitrachenko T. I. , Semenov V. M. , Egorov S. K.
Published: October 2022

Cytomegalovirus plays an essential role in human pathology. Primary infection usually occurs in childhood and subsequently, a lifelong latency is formed which the virus replicates by evading the immune response. In recent years, more and more researchers have concluded that cytomegalovirus reactivation may occur in critically ill patients. Despite the available evidence, data on reactivation in this group of patients are limited by the relatively small sample size, the variety of patient groups studied, the differences in study methodology, and the variability in reported results, which excludes the possibility of summarizing the results.

This study aimed to determine the frequency of reactivation of cytomegalovirus infection in critically ill patients and to identify its main clinical features.

Materials and methods. The study included 118 critically ill patients with severe bacterial and viral-bacterial infections accompanied by multiple organ dysfunction. Cytomegalovirus reactivation was determined by the detection of DNA in combination with the presence of IgG.

Results. Reactivation was detected in 36.4% of cases. Frequency and terms of reactivation in blood and sputum as well as trends of viral load changes in dynamics were shown. The main clinical features of reactivation in different pathologies (sepsis of bacterial etiology, COVID-19, non-septic critical patients) were noted. HCMV DNA was more frequently detected in the blood of septic patients (44.8%) compared with COVID-19 (13.0%, p<0.05) and non-septic critically ill patients (19.2%, p<0.05). COVID-19 was characterized not only by lower detection of HCMV DNA in the blood but also by the lowest viral loads (p<0.05). HCMV DNA in sputum was detected comparably frequently in sepsis (38.1%) and COVID-19 (33.3%), but the highest viral loads were characteristic of patients with sepsis (p<0.05).
The role of gene polymorphism of some immune response molecules in the development of acute virus-induced bronchiolitis
Authors: Bochkareva L. S. , Miromanova N. A. , Miromanov A. M.
Published: October 2022

The aim of research: To investigate the genetic polymorphism of immune response molecules (TNFα-308G> A (rs1800629), IL4-589C>T (rs2243250), IL10-592C> A (rs1800872), IL10-819C> T (rs1800871), IL10-1082G>A (rs1800896), IL-17A-197G> A (rs2275913), IL- 17F-161His> Arg (rs763780), TLR-2-753Arg>Gln (rs5743708), TLR-6-249Ser>Pro (rs5743810) and assess their prognostic value in the development of acute virus-induced bronchiolitis.

Materials and methods. The study included children of the first year of life, whose average age was 4.2 ± 3.7 months. The main group consisted of 106 patients with moderate and severe acute viral bronchiolitis, more often associated with respiratory syncytial virus (56.6%). The control group consisted of 100 healthy children of the same age who had no signs of acute respiratory infection at the time of examination and did not receive passive immunoprophylaxis of respiratory syncytial infection. Genotyping was performed using the polymerase chain reaction method. The analysis of the results included the compliance with the Hardy-Weinberg law, the χ 2 test, the relative chance, and its 95% confidence interval. To assess the distribution of the claimed gene polymorphisms and their alleles, we used the general (χ2 test, df =2) and multiplicative (χ2 test, df =1) inheritance models.

Results. It was revealed that the risk of developing acute viral bronchiolitis is increased compared to the healthy population in carriers of the following genotypes: CC, ST gene IL10-819C> T (rs1800871), GG, AA gene IL-17A-197G> A (rs2275913), HisHis gene IL-17F-161His> Arg (rs763780), SerSer, SerPro gene TLR-6-249Ser> Pro (rs5743810), GG gene TNF-α-308G>A (rs1800629). The TT genotype of the IL10-819C>T (rs1800871) gene is associated with a high risk of developing bacterial complications (pneumonia) in viral bronchiolitis. Carriers of genotypes AA, CC of the IL10-592C> A (rs1800872) gene have an increased likelihood of a severe course of viral bronchiolitis.

Conclusion. Genetic analysis of gene polymorphism IL10-592C> A (rs1800872), IL10-819C> T (rs1800871), IL-17A-197G> A (rs2275913), IL-17F-161His> Arg (rs763780), TLR-6-249Ser> Pro (rs5743810), TNF-α-308 G>A (rs1800629) can be used as a personalized developmental criterion acute virus-induced bronchiolitis in children, determining the severity of its course and the likelihood of complications.
Exploring the relationship between tourists’ emotional experience, destination personality perception, satisfaction and behavioral intentions
Authors: Kovacic Sanja , Sagovnovic Ivana
Published: October 2022

The relationship between tourists? emotional experience and perception of destination brand personality, has not been empirically explored before. Moreover, there is a literature gap in understanding how emotional experience, destination personality, destination satisfaction, and behavioral intentions, interact together in one model. Based on this, the principal aim of this study is to analyze how tourists? emotional experience affects the perception of destination personality traits, as well as how these two constructs relate to tourists? satisfaction and behavioral intentions. In order to explore this, the survey was conducted on a sample of 203 domestic and international tourists, who have visited the city of Novi Sad, while Structural Equation Modeling (SEM) was applied to test the hypothesized model. The results confirmed the positive role of emotional experience in shaping destination personality and destination satisfaction. Destination satisfaction and certain personality traits positively predicted behavioral intentions. Theoretical and managerial implications are discussed in the paper.
Fear of COVID-19 and sleep problems in Turkish young adults: Mediating roles of happiness and problematic social networking sites use
Authors: Yıldırım Murat , Öztürk Akif , Solmaz Fatma
Published: October 2022

There is burgeoning evidence showing the negative impact of fear of COVID-19 on various mental health outcomes. Little is known about the underlying mechanism of the relationship between fear of COVID-19 and sleep problems in times of health crisis. This study aims to examine whether fear of COVID-19 was associated with sleep problems through happiness and problematic social networking sites (SNS) use. Participants included 506 young adults (67.6% females; mean age = 28.23 ? 8.73 years) drawn from the general public in Turkey. Results showed that fear of COVID-19 had a sgnificant predictive effect on happiness (? = -.15, p < .01), problematic SNS use (? = 0.32, p < .01), and sleep problems (? = .36, p < 0.01). Most importantly, happiness (effect = 0.02, 95% CI [0.01, 0.04]) and problematic SNS use (effect = 0.07, 95% CI [0.04, 0.11]) mediated the impact of fear of COVID-19 on sleep problems. These findings suggest that happiness and problematic SNS use are important factors that can help explain the association between fear of COVID-19 and sleep problems among young adults. Intervention and prevention programs can be developed to reduce the effect of fear the of COVID-19 pandemic on sleep problems of young adults by considering the roles of happiness and SNS use in the context of health crises or other stressful situations.
Pengembangan Wisata di Desa Hargorejo, Kecamatan Kokap, Kabupaten Kulon Progo, Daerah Istimewa Yogyakarta
Authors: Lukisworo Agustinus Aryo
Published: October 2022

Kuliah Kerja Nyata (KKN) Periode 79 of Universitas Atma Jaya Yogyakarta from April to May 2021, was carried out through online mode. This was due to the Covid-19 pandemic spread prevention in Indonesia. Within this period, the third group of A Unit was assigned to the Hargorejo Village, Kokap, Kulon Progo, Daerah Istimewa Yogyakarta. All of the third group KKN programs were drafted upon secondary data that obtained by online inquiries. The findings show that Hargorejo Village has a promising tourism potency to develop, namely Gunung Kuniran. In this location, aside with tourist attraction, there are also plantation and cultural arts resources that could be optimized to support the development of the tourism potency. Based on SWOT analysis of the existing condition, there are three program that should be done to develop the Gunung Kuniran tourism potency, that are agro-tourism development, arts performance stage renovation, and public facility refinement. Hopefully the Gunung Kuniran tourism development will lead to the economic development of Hargorejo Village.
Kajian Potensi Desa Sebagai Upaya Pengembangan Ekonomi Masyarakat Desa Sambirejo, Kecamatan Ngawen, Kabupaten Gunungkidul
Authors: Kristiyani Ika Murti
Published: October 2022

Kegiatan Pengabdian Kepada Masyarakat (KPKM) pada kesempatan ini dilakukan tanpa pengamatan langsung ke lokasi akibat adanya Pandemi Covid-19 di Indonesia. Lokasi KPKM ini berada di Desa Sambirejo, Kecamatan Ngawen, Kabupaten Gunungkidul, Daerah Istimewa Yogyakarta. Tujuan dalam kegiatan ini adalah melakukan pemetaan dan pengembangan potensi yang terdapat di Desa Sambirejo. Dalam analisis penelitian yang menggunakan metode deskriptif dari data primer maupun sekunder ditemukan bahwa Desa Sambirejo memiliki keunggulan. Di sana ada keindahan pemandangan alam, yaitu Air Terjun Banyunibo yang masih perlu dioptimalkan agar menarik wisatawan. Selain itu, ada potensi pohon pisang dalam komoditas pertanian yang bisa dimanfaatkan. Pelepah dari pohon pisang bisa menjadi bahan utama dalam pembuatan handsanitizer[1]. Organisasi Lembaga Pemberdayaan Masyarakat Desa (LPMD) dapat memberdayakan masyarakat Desa Sambirejo dengan program pembuatan handsanitizer. Diharapkan kegiatan ini menjadi salah satu referensi yang dapat dipelajari dan dipraktekan oleh warga Desa Sambirejo, sehingga dapat menjadi alternatif ide usaha baru yang tentunya dapat berdampak positif untuk kemajuan dan perkembangan Desa Sambirejo.