bluuebunny/crossref_metadata_2025 huggingface dataset:
Efeitos na Aprendizagem para a Auditoria Interna na Mitigação do Risco de Corrupção nas Empresas Envolvidas com a Operação Lava Jato
Authors: Maciel dos Santos Antonio Edson , Cristina Segura Liliane , Souza Vasconcelos Ana Lucia Fontes de , Imoniana Joshua Onome
Published: July 2024

Objetivo: Este estudo tem como objetivo identificar os efeitos na aprendizagem para a Auditoria Interna na mitigação do risco de corrupção em empresas envolvidas com a Operação Lava Jato, comparando o antes e o depois do evento.
Método: Esta pesquisa tem abordagem qualitativa. A população é composta por sete empresas, grandes grupos econômicos de origem brasileira e com atuação em diversos países. O tipo de amostra escolhido foi a não-probabilística por acessibilidade. Com aplicação de entrevista semiestruturada para 6 dos respondentes e 1 entrevista não-estruturada por apresentar características diferentes das demais. O roteiro é dividido em três dimensões, no total de 41 questões, aplicando técnica de análise de conteúdo, divididas em quatro categorias, de acordo com a teoria.
Resultados: Os resultados mostram as principais lições aprendidas: (i) maior foco na mitigação do risco de corrupção; (ii) priorização de investimentos no aumento de pessoal, treinamento e tecnologia; (iii) melhoria na eficiência e qualificação da Auditoria Interna; e (iv) criação de oportunidades de negócios.
Originalidade/Relevância: evidenciando que a organização pode aprender com as punições as quais foram submetidas e, em alguns casos, formular novas estratégias de crescimento
Contribuições teóricas/metodológicas: Esta pesquisa é relevante por relacionar a aprendizagem organizacional com as sanções incorridas pela Lava Jato, evidenciando que a Auditoria Interna tem um papel fundamental na luta de combate à corrupção e na mitigação de seus riscos.
Contribuições sociais/para a gestão: As empresas podem utilizar este estudo para se desenvolver do ponto de vista estratégico quando possuem algum tipo de risco de compliance.
Deux Siècles d’Arts et de Sciences à Nice et Villefranche-sur-Mer : 2) Les Modernes : 1960 à 2024
Authors: Sardet Christian
Published: July 2024

Dans l’article complémentaire (Sardet 2024-1 Les anciens : de 1800 à 1900), nous relatons l’histoire de l’exploration de la faune de la région niçoise, et en particulier des organismes pélagiques. Dans ce deuxième article, nous examinons comment, plus d’un siècle plus tard, la recherche scientifique en biologie et physiologie cellulaire et moléculaire du développement a évolué à la station marine de Villefranche-sur-Mer. Alors que la biologie et l’écologie du plancton sont prédominants sur le site et ont progressivement conduit à la croissance d’un grand laboratoire d’Océanographie à Villefranche-sur-Mer (LOV), à partir des années 1960 de nouvelles équipes de recherche sur la physiologie des poissons et des protistes ont été accueillies. Et dans les années 1980, une équipe de recherche créée par le CNRS a évolué en l’actuel Laboratoire de Biologie du Développement (LBDV). Nous décrivons comment les techniques d’imagerie et de biologie cellulaire moléculaire ont permis d’analyser l’ovogénèse, la fécondation et le développement chez les oursins, tuniciers, cténophores, cnidaires et d’autres organismes marins dont certains étaient déjà étudiés par les fondateurs et les visiteurs de la station marine au 19ème siècle. Nous soulignons que de nouveaux modèles - l’ascidie Phallusia, l’appendiculaire Oikopleura et la méduse hydrozoaire Clytia – ont vu le jour sur le site. Nous discutons aussi les façons de promouvoir les découvertes par le biais de photographies, de dessins, d’expositions et sites internet esthétiques.
Intellectual capital and firm performance of Jordanian financial institutions
Authors: Ibrahim Mustafa Dalia , Mohammad Alzebdieh Rami , Abdullatif Modar , Akef Al Majali Safa’
Published: July 2024

This study aims to explore the financial implications of intellectual capital in the Jordanian financial sector during the period 2009–2018. It uses Pulic’s (2004) value-added intellectual capital model, particularly capital employed efficiency, structural capital efficiency, and human capital efficiency, and tests its potential effect on firm financial performance measures, including return on assets, return on equity, asset utilization ratio, and Tobin’s Q. The study’s findings demonstrate that value-added intellectual capital positively influences the financial performance of Jordanian financial companies. Value-added intellectual capital is not found to have a significant impact on productivity, but it is strongly and positively related to firm profitability and market value. As for the main components of value-added intellectual capital, human capital efficiency has a significantly positive impact on a company’s performance, but regarding structural capital efficiency, the outcomes vary depending on the measure of firm performance. Notably, when firms are categorized into sub-industries (banks, insurance companies, and financial service companies), it is found that the profitability of insurance companies is more affected by intellectual capital than that of banks or financial services. The results also show that investors place great importance on the efficiency of intellectual capital, particularly within the banking industry. Furthermore, implementing Shariah compliance standards boosts the positive effect of structural capital efficiency on corporate market value and reinforces the positive influence of human capital efficiency on productivity.
Factors influencing consumer behavior towards intention and the selection of luxury hotels in Malaysia using Theory of Planned Behavior
Authors: Chee Hoo Wong , Mei Poh Ng , Kamran Khan Muhammad
Published: July 2024

This study aimed to examine the impact of the Theory of Planned Behavior on Malaysian luxury hotel selection. To achieve this objective, the study examined the influence of attitude, subjective norms, perceived behavioral control, and fake reviews on the choice of luxury hotels in Malaysia. The study also investigates whether intention mediates the relationship between these variables and luxury hotel selection. The research method was quantitative in nature and to collect the necessary data, convenience sampling was used on an online questionnaire, resulting in 400 valid responses. The respondents were residents of Malaysia aged over 18 years old who had stayed at luxury hotels before, as they are qualified to answer the research objectives. For this study, four- and five-star hotels are considered as luxury hotels. The collected data were then analyzed using IBM SPSS version 26, using descriptive, regression, and mediation analysis through Hayes process. The results from the regression analysis revealed the predictive power of each variable, while the mediation analysis demonstrated that intention mediates the relationship between attitude, subjective norms, and perceived behavioral control in luxury hotel selection. According to this study, attitude, subjective norms, perceived behavioral control, and fake reviews influence luxury hotel choices. Intention significantly mediates the association between attitude, subjective norms, perceived behavioral control, fake reviews, and luxury hotel choices.
Exploring intrinsic factors that affect quality job and turnover intention in the Chinese educational services industry
Authors: Ramasamy Ganesh , Mengling Wu
Published: July 2024

Organizations must attain a sustainable competitive advantage via the workforce. Active employee engagement can foster motivation and provide intrinsic job satisfaction. This study aims to analyze the impact of prospective intrinsic factors on the turnover intention of academic staff in the educational service industry in Anhui, China. A quantitative study method was devised using the Daniel Pink’s theory with a survey questionnaire consisting of 51 items. The study used a 5-point Likert scale. Nonprobability sampling with the snowball method was exercised for 403 fully completed responses for data analysis using the SPSS program version 23. The Pearson correlation analysis revealed a significant and robust inverse relationship between employee turnover intention and all of the independent variables examined (r² = 55.06 for managerial behavior empowerment, r² = 54.76 for psychological empowerment, r² = 54.46 for career growth opportunity, r² = 63.84 for organizational commitment, and r² = 27.46 for compensation). The multiple regression analysis was subsequently implemented. The model evaluation yields an adjusted R² value of 0.685, signifying that the independent variables collectively account for approximately 69% of the variance in the dependent variable, except for compensation, which exhibits a significant positive correlation with turnover intention. However, it is impossible to disregard the impact of compensation as the silence factor. Appropriate delivery of this baseline reward is necessary to ensure that it satisfies the fundamental requirements of the employee and fosters intrinsic motivation.
Acknowledgment This study received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Selenoacetylenes Protect against Beta-Amyloid Peptide-Induced Paralysis and Promote Longevity in Caenorhabditis elegans
Authors: Figueiredo Maria Isabela , Mello Ivani , Targanski Sabrina , Duarte Juliana , Vasconcelos Leonardo , Stein André Luiz , Soares Marcos Antonio
Published: July 2024

Selenium-containing compounds exhibit diverse biological activities, such as antioxidative, anti-inflammatory, and cancer preventive effects. Using Caenorhabditis elegans as a model organism, we assessed the toxicity, neuroprotective, antioxidant properties, and impact on longevity of 11 selenoacetylenes. Their toxicity and bioactivities varied based on molecular structure. Selenoacetylenes with butyl substituents were toxic to Galleria mellonella larvae. The presence of but-3-in-2-ol radical increased antiprotozoal activity against Tetrahymena pyriformis. Compared to the positive control (Nimitz® EC), selenoacetylenes were less toxic to nematode worms and eggs. Selenoacetylenes significantly reduced amyloid beta (Aβ) paralysis in C. elegans CL4176 worms, increased longevity by 18 to 22%, along with improving survival after oxidative or thermal stress. Galantamine, showed inferior results. These findings enhance our understanding of selenoacetylenes on neuroprotection, antioxidant activity, and longevity in C. elegans. Future mammalian studies will further elucidate mechanisms and explore the potential therapeutic use of selenoacetylenes in treating Alzheimer’s disease and longevity.
Transformación campesina
Authors: Fontalvo Ramos Luis Eduardo
Published: July 2024

This book analyzes the interactions that the rural community of El Cinco, in the municipality of Manaure (Cesar), has established with the land in which they have lived and worked for half a century. In this way, it addresses elements that demonstrate the transformation of the productive systems of the village, while also accounting for the forms of local organization and community fabric, as well as the tradition and culture of the peasantry. The text is also supported by an audiovisual production around the history of two peasant women as a participation strategy in the investigative process. This ethnography narrates the transformation of life in the area: from its settlement, through the displacement of traditional crops to illicit ones, and then the eradication and environmental impact, continuing with the armed conflict and forced displacement, to culminate in the return to the territory and the implementation of blackberry crops. Thus, different events, ruptures, and overlaps are presented through the collective memory of these Colombian peasants.
Microneedles: An Efficient Technique to Increase Transdermal Drug Delivery System
Authors: Roy Sanjit Kr. , Ali Kazi Asraf , Biswas Mahua , Dey Abhijit , Bishal Amlan , Kuiry Abhradeep
Published: July 2024

Transdermal Drug Delivery Systems (TDDS) have gained attention as a viable substitute
for traditional drug administration methods because of their controlled release capabilities and
non-invasive design. Microneedles are a new and effective technology that has attracted a lot of attention
recently to enhance the capabilities of TDDS further. The study on microneedles and their
potential to improve transdermal medication delivery is thoroughly reviewed in this review article.
The study initiates by clarifying the difficulties linked to traditional medication delivery techniques
and the benefits provided by transdermal channels. The article then explores the development
of microneedle technology, outlining the several kinds of microneedles—solid, hollow, and
dissolving—as well as their uses. Because of their special capacity to penetrate the skin's protective
layer painlessly and their ability to distribute drugs precisely and precisely, microneedles are
a highly useful instrument in pharmaceutical research. The materials, geometry, and manufacturing
processes that affect the design and creation of microneedles are critically analyzed and presented.
The manuscript delves into the latest developments in microneedle technology, encompassing
the utilization of biodegradable polymers, smart materials, and sensing components for in-the--
moment monitoring. This analysis concludes by highlighting the noteworthy advancements in the
field of microneedles and their potential to transform transdermal drug delivery systems. This thorough
knowledge seeks to further the current discussion in pharmaceutical research, encouraging
creativity and opening the door for the creation of safer, more effective drug delivery systems.
Unwinding the Multi-Perspectives of Hyaluronic Acid as a Potent
Cosmeceutical
Authors: Datta Sinjini , Pal Rashmi Saxena , Pal Yogendra , Chaitanya MNVL , Srivastava Preeti
Published: July 2024

The purpose of this study is to evaluate hyaluronic acid (HA), sometimes referred to as
hyaluronan or hyaluronate, as well as its derivatives and how they are used in cosmetic formulations.
N-acetylglucosamine and D-glucuronic acid are the two disaccharides that make up HA, a glycosaminoglycan that was first isolated from the vitreous humor of the eye and then found in other tissues
and fluids, including the synovial fluid and articular cartilage. It is found in all vertebrates, including
humans, and has a variety of roles in biological processes, such as wound healing, inflammation, cell
differentiation, and embryological development. With its moisturizing and anti-aging properties, HA
offers numerous advantages over other chemicals used in skin regeneration. The biological activity
and skin penetration of HA are influenced by its molecular weight. The current study outlines the key
elements of hyaluronic acid's usage in cosmetology, given its broad range of uses and applications in
ophthalmology, arthrology, pneumology, rhinology, aesthetic medicine, cancer, nutrition, and cosmetics. There is a discussion of the biological impact of HA at the skin's level as well as any possible
negative consequences. From the brand portfolios of the most well-known manufacturers, a few readily available cosmetic items containing HA have been discovered, and their composition has been
assessed.
Gold Nanoparticles: An Emerging Novel Technology for Targeted Delivery System for Site-specific Diseases
Authors: Kumar Prevesh , Chandra Phool , Verma Navneet , Diksha  , Sharma Aditya , Mani Munesh , Hussain Zaira
Published: July 2024

:

Gold Nanoparticles (GNPs) have emerged as a novel technology in the field of targeted
delivery systems, offering promising solutions for site-specific disease treatment. These nanoparticles
possess unique physicochemical properties, such as controlled size, shape, and surface chemistry,
which enable precise manipulation for enhanced therapeutic efficacy. The biocompatibility and ease
of functionalization of GNPs facilitate the conjugation with various biomolecules, including drugs,
peptides, and nucleic acids, thereby improving their targeted delivery capabilities. Recent advancements
in nanotechnology have leveraged GNPs for the treatment of a range of diseases, particularly
in oncology, cardiology, and neurology. In cancer therapy, GNPs can be engineered to target tumor
cells selectively, minimizing damage to healthy tissues and reducing side effects. This is achieved
through the conjugation of GNPs with tumor-specific ligands, antibodies, or aptamers, which direct
the nanoparticles to malignant cells, allowing for localized drug release and improved therapeutic
outcomes. Moreover, GNPs exhibit remarkable potential in diagnostic imaging and photothermal
therapy. Their unique optical properties, such as surface plasmon resonance, enable their use as contrast
agents in imaging techniques, providing high-resolution and real-time monitoring of disease
progression. In photothermal therapy, GNPs convert light energy into heat, effectively destroying
targeted cells with minimal invasiveness. The development of GNP-based delivery systems also addresses
significant challenges in drug resistance and bioavailability. By overcoming biological barriers
and enhancing cellular uptake, GNPs improve the pharmacokinetics and pharmacodynamics of
therapeutic agents. However, despite these advancements, the clinical translation of GNPs faces challenges
such as potential toxicity, long-term stability, and regulatory hurdles. In conclusion, gold nanoparticles
represent a cutting-edge approach in targeted delivery systems, offering significant potential
for site-specific disease treatment. Continued research and innovation are essential to overcome
existing challenges and fully realize the clinical applications of GNPs, ultimately revolutionizing
precision medicine.

:

Gold nanoparticles exhibit unique physicochemical and optical properties. The gold nanoparticles
have advanced techniques to cure different chronic diseases. Today, gold nanoparticles are aided by
photodynamic therapy and radiation therapy as drug carriers. Due to this, researchers now focus on
medical sciences to treat various diseases and therapeutic applications. This review provides all the
aspects of gold-based nanoparticles, methods, and their pharmacological benefits in different fields
of medical sciences. We also discuss various preparation methods and their advantages in pharmaceutical
formulations.
CNRBind: Small Molecule-RNA Binding Sites Recognition via Site
Significant from Nucleotide and Complex Network Information
Authors: Zhang Lichao , Xiao Kang , Wang Xueting , Kong Liang
Published: July 2024

Background:

Small molecule-RNA binding sites play a significant role in developing
drugs for disease treatment. However, it is a challenge to propose accurate computational tools for
identifying these binding sites.

Method:

In this study, an accurate prediction model named CNRBind was constructed by extracting
site significant information from nucleotide and complex networks. We designed complex networks
and calculated three topological structural parameters according to RNA tertiary structure.
Acknowledging nucleotide interdependence, a sliding window was selected to integrate the influence
of adjacent sites. Finally, the model was constructed using a random forest classifier

Results:

Compared to the other computational tools, CNRBind was competitive and had excellent
discriminative ability for metal ion-binding site prediction. Furthermore, statistic analysis revealed
significant differences between CNRBind and existing methods. Additionally, CNRBind is a promising
predictor in cases where experimental tertiary structure is unavailable.

Conclusion:

These results show that CNRBind is effective because of the proposed site significant information
encoding strategy. The approach provides a reasonable supplement for biology researches.
The dataset and resource codes can be accessed at: https://github.com/Kangxiaoneuq/CNRBind.
PHD-BAH Domain in ASH1L Could Recognize H3K4 Methylation and Regulate the Malignant Behavior of Cholangiocarcinoma
Authors: Zhang Xiang-Yu , Li Yue
Published: July 2024

Background:

Histone methyltransferase absent, small, or homeotic discs1-like (ASH1L) is composed
of su(var)3-9, enhancer of zeste, trithorax (SET) domain, pleckstrin homology domain (PHD) domain, middle
(MID) domain, and bromo adjacent homology (BAH) domain. The SET domain of ASH1L is known to mediate
mediate H3K36 dimethylation (H3K36me2) modification. However, the specific functions of the PHD-BAH
domain remain largely unexplored. This study aimed to explore the biological function of the PHD-BAH domain
in ASH1L.

Methods:

We employed a range of techniques, including a prokaryotic fusion protein expression purification
system, pull-down assay, Isothermal Titration Calorimetry (ITC), polymerase chain reaction (PCR), and sitedirected
mutagenesis, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR-Cas9) gene editing,
cell culture experiment, western blot, cell proliferation assay, and cell apoptosis test.

Results:

The PHD-BAH domain in ASH1L preferentially binds to the H3K4me2 peptide over H3K4 monomethylation
(H3K4me1) and H3K4 trimethylation (H3K4me3) peptide. Notably, the W2603A mutation within the
PHD-BAH domain could disrupt the interaction with H3K4me2 in vitro. Compared with wild-type Cholangiocarcinoma
(CHOL) cells, deletion of the PHD-BAH domain in ASH1L led to increased CHOL cell apoptosis and
reduced cell proliferation (P < 0.001). Additionally, the W2603A mutation affected the regulation of the proteasome
20S subunit beta (PSMB) family gene set.

Conclusion::

W2603A mutation was crucial for the interaction between the PHD-BAH domain and the H3K4me2
peptide. ASH1L regulated CHOL cell survival and proliferation through its PHD-BAH domain by modulating the
expression of the PSMB family gene set.
Utilising Self-acupressure to Manage Type 2 Diabetes Mellitus Control Parameters
Authors: Sukarja I Made , Sukawana I Wayan , Widya Ningtyas Listina Ade , Juanamasta I Gede , Aungsuroch Yupin
Published: July 2024

Background

In Indonesia, only two-thirds of patients diagnosed with diabetes mellitus (DM) are projected to receive both non-pharmacological and pharmaceutical treatment. The majority of patients receiving the medication do not achieve adequate control of DM.

Objective

The purpose of this study was to examine the impact of self-administered acupressure on type 2 DM (T2DM) management parameters, specifically targeting ST36, LR3, KI3, and SP6 acupuncture points.

Methodology

This study utilised an experimental research design and included a total of 25 patients with diabetes mellitus from the Gianyar Public Health Centre. Participants were selected using a simple random sampling technique. The individuals underwent a 13-week training program to learn self-acupressure techniques targeting certain areas of their bodies, including Zusanli (ST36), Taichong (LR3), Taixi (KI3), and Sanyinjiao (SP6). The control parameters of diabetes mellitus were examined both before and after therapy.

Results

The analysis revealed significant differences in the p-values of various control parameters before and after self-acupressure. Specifically, the p-values for HbA1c, LDL, BMI, systolic pressure, fasting blood glucose, and 2 hours post-prandial glucose were found to be p<0.001, indicating self-acupressure, as a complementary therapy, has an impact on these parameters. However, the p-value for diastolic pressure was 0.57, suggesting that self-acupressure did not have a significant effect on this parameter.

Conclusion

The application of self-acupressure at certain points such as ST36, LR3, Taixi, and SP6 has been proven to effectively reduce the control parameters of diabetes mellitus including HbA1c, LDL, BMI, systolic pressure, and fasting blood glucose levels. It is recommended that those who are enrolled in the complementary traditional health care program in the community provide advice on how to perform self-acupressure in diabetic patients.
Challenges in Insulin Therapy: Perspectives of Malaysian Diabetes Educators
Authors: Yahya Nur Shazwaniza , Mulud Zamzaliza Abdul , Daud Ahmad Zamir Che , Ahmad Fauziah
Published: July 2024

Background

Individuals with type 2 Diabetes Mellitus (T2DM) commonly need insulin therapy as their condition advances. Healthcare providers often face difficulties in managing patients who require insulin treatment. Gaining insight into the views of healthcare professionals on the obstacles encountered by patients using insulin can aid in improving care and developing effective treatment plans.

Objective

This study explores the views of Malaysian diabetes educators on the barriers faced by patients in using insulin.

Methods

Semi-structured qualitative interviews were conducted with diabetes educators (n=8) from the northern, central, and southern regions of Malaysia who were involved in diabetes care. We used an interview guide to facilitate the in-depth interviews, which were digitally recorded, transcribed verbatim, and analyzed using a thematic approach.

Results

Five themes were identified: the occurrence of side effects, the need for better patient education, negative perceptions towards insulin, the financial burden, and the complexity of adherence to treatment. There is a lack of patient education on proper glucose monitoring and how to optimize insulin therapy. The cost of treatment and patient ignorance are highlighted when discussing patient self-monitoring of blood glucose. Diabetes educators recognize that the absence of an effective follow-up mechanism is a major issue, particularly for those patients who fail to maintain consistent appointment schedules.

Conclusion

This research highlights five significant obstacles to maximizing the effectiveness of insulin therapy. Diabetes educators who identify and address these challenges can empower patients to manage their condition effectively. To overcome systemic barriers, government involvement is needed in creating insulin follow-up initiatives, establishing multidisciplinary teams for diabetes care, empowering education strategies, and providing financial support for self-monitoring.
Green Synthesis of Thiazoles and Thiadiazoles having Anticancer Activities under Microwave Irradiation
Authors: Majhi Sasadhar , Mitra Piyali , Mondal Pankaj Kumar
Published: July 2024

:

Sulfur and nitrogen-containing heterocycles have received a great deal of attention due to their unique structures and therapeutic relevance. Thiazoles and thiadiazoles are important five-membered heterocycles containing sulfur and nitrogen atoms that draw the special attention of re-searchers due to their synthetic diversity and potent pharmacological properties. Thiazoles and thi-adiazoles are used in agrochemicals, liquid crystals, sensors, the cosmetic industry, cyanine dyes, etc. Sometimes, organic synthesis, including thiazoles and thiadiazoles syntheses with the help of conventional methods, is laborious work, while synthesis of promising organic molecules using microwave irradiation provides better yields, diminishes the reaction time, and reduces unwanted side products. The major causes of death worldwide are due to cancer. Current research demands the design and preparation of novel compounds, including thiazoles and thiadiazoles, that may help to combat cancer, as chemotherapy or chemo drugs suffer from some demerits, including toxicity, lack of selectivity, resistance, and side effects. Hence, the review focuses on the microwave-assisted synthesis of thiazoles and thiadiazoles as a sustainable technique for the first time, and it also aims to highlight the anticancer activities of thiazoles and thiadiazole derivatives elegantly.
Contemporary Nanoemulsion Research: Extensive Examination of Self-Nanoemulsifying Drug Delivery Systems
Authors: Patel Aakriti , Singh Astha , Minocha Neha
Published: July 2024

The administration of new pharmaceutical compounds orally can pose certain challenges
in terms of drug absorption, bioavailability, and pharmacokinetic profile. However, a widely
recognized method for enhancing bioavailability involves lipid-based drug delivery systems.
Lipid-based drug delivery systems (LBDDS) are the most favourable method for formulating
medicines that have low solubility in water. Nanotechnology exerts a significant impact on the
therapeutic efficacy of hydrophobic medicines and has emerged as a crucial method in the field of
drug delivery research. Self-nanoemulsifying drug delivery systems (SNEDDs) are an important
approach that combines the advantages of lipid-based drug delivery systems (LBDDS) and nanotechnology.
SNEDDs are currently the favoured method for enhancing the formulation of pharmaceuticals
that have low solubility in water. SNEDDs are homogenous mixtures that can self-emulsify
spontaneously with gentle stirring, forming an oil-in-water emulsion that conveniently protects
and creates a pathway for the lipophilic drug. The small particle size of <200nm increases
the solubilisation capacity of the drug by increasing its surface area. SNEDDs have demonstrated
the ability to enhance the bioavailability of medicines that are not easily soluble in water.
SNEDDs stand apart from other solubility enhancement approaches due to their inclusion of
biodegradable components, their ease of large-scale manufacture, and their numerous potential for
drug targeting. The aim of the present review was to provide basic knowledge about formulation,
applications, and benefits of using SNEDDs. A detailed manuscript has been prepared by doing a
literature survey on databases like Google Scholar, SCOPUS, and Pubmed to review the current
state of nanotechnology applications, industrial developments, and challenges for using SNEDDS
as a novel delivery system is provided in this manuscript.
Developing a Website-Based Digital Platform to Market Wedding Planner Services in Yogyakarta City
Authors: Fatimah Azzahra  , Mausa Agrevinna
Published: July 2024

Digital platform is rarely used to market wedding planning industry, so the development of a digital platform based on the wedding planning service website is needed. This research aimed to (1) design the concept for developing a digital platform for wedding planning service websites; (2) develop a digital platform for the wedding planning service website (3) measure the feasibility of the developed digital platform for the wedding planning service website. This research employed the Research and Development (R&D) method with 4D development model that consists of (1) Define (2) Design (3) Develop, and (4) Disseminate stages. The product of this research is the wedding planning service website entitled "Wedding Market". The website displays information related to wedding vendors in the Yogyakarta City area. The vendors provide services and products for photography, make-up, wedding gowns and suits, and decoration. The developed website went through a validity test, and it was found that the value obtained is 94.25% (Very Feasible). Then, based on the results of media expert validation, the websites is considered Very Feasible (89.17%). From the overall results, it can be concluded that the wedding planning service website "Wedding Market" is very feasible and well received by users.
The Influence of Self-Concept and Work Competence on Work Readiness of Office Administration Students
Authors: Alfi Mustofiyah  , Wahyu Rusdiyanto
Published: July 2024

This research aimed to determine and investigate the magnitude of the influence of self-concept and work competency on the work readiness of vocational students class of 2019, UNY Office Administration study program. This research employed the quantitative approach with a correlational type of research. The population in this study included vocational students from the class of 2019 of Office Administration study program at UNY, and the sample was taken from 80 students. The data were collected by means of a questionnaire. Then, data analysis techniques are carried out by describing research data, testing prerequisites for analysis, and analysing data in order to answer research questions. The results of the study found that (1) there is a positive and significant influence of self-concept on work readiness (14.3%) (2) there is a positive and significant influence of work competency on work readiness, (10.3%), and (3) there is a positive and significant influence of self-concept and work competency simultaneously on work readiness (24.6%), which means that self-concept and work competence are predictors of work readiness.
Further Exploring the Public Health Implications of the Network Scale-Up Method: Cross-Sectional Survey Study
Authors: Jing Liwei , Yu Hongmei , Lu Qing
Published: July 2024

Background

The decline in the number of new HIV infections among adults has slowed down, gradually becoming the biggest obstacle to achieving the 2030 target of ending the HIV/AIDS epidemic. Thus, a political declaration to ensure that 90% of people at high risk of HIV infection can access comprehensive prevention services was proposed by the United Nations General Assembly. Therefore, obtaining an accurate estimated size of high-risk populations is required as a prior condition to plan and implement HIV prevention services. The network scale-up method (NSUM) was recommended by the United Nations Programme on HIV/AIDS and the World Health Organization to estimate the sizes of populations at high risk of HIV infection; however, we found that the NSUM also revealed underlying population characteristics of female sex workers in addition to being used to estimate the population size. Such information on underlying population characteristics is very useful in improving the planning and implementation of HIV prevention services. This is especially relevant for people who inject drugs, where in addition to stigma and discrimination, criminalization further hinders access to HIV prevention services.

Objective

We aimed to conduct a further exploration of the public health implications of the NSUM by using it to estimate the population size, popularity ratio, and information transmission rate among people who inject drugs.

Methods

A stratified 2-stage cluster survey of the general population and a respondent-driven sampling survey of people who inject drugs were conducted in the urban district of Taiyuan, China, in 2021.

Results

The estimated size of the population of people who inject drugs in Taiyuan was 1241.9 (95% CI 1009.2‐1474.9), corresponding to 4.4×10−2% (95% CI 3.6×10−2% to 5.2×10−2%) of the adult population aged 15‐64 years. The estimated popularity ratio of people who inject drugs was 53.6% (95% CI 47.2%‐60.1%), and the estimated information transmission rate was 87.9% (95% CI 86.5%‐89.3%).

Conclusions

In addition to being used to estimate the size of the population of people who inject drugs, the NSUM revealed that they have smaller-sized personal social networks while concealing their drug use, and these underlying population characteristics are extremely useful for planning appropriate service delivery approaches with the fewest barriers for people who inject drugs to access HIV prevention services. Therefore, more cost-effectiveness brings new public health implications for the NSUM, which makes it even more promising for its application.
Innovations in technology-enabled behavioral and mental health services: A preliminary look at the processes and outcomes of a platform using health coaching, benefit navigation, and machine learning (Preprint)
Authors: Wilbourne Paula , Mirch-Kretschmann Susan , Walker Denise D , Varghese Michael , Arnetoli Roberto
Published: July 2024

BACKGROUND

Limited access to quality mental health treatment harms health and quality of life while costing individuals and organizations millions in increased medical spending and reduced productivity at work. Too few qualified professionals, inconsistent quality, inaccessibility, and stigma thwart traditional solutions. Innovations must be scalable, science-based, and timely.

OBJECTIVE

Limited access to quality mental health treatment harms health and quality of life while costing individuals and organizations millions in increased medical spending and reduced productivity at work. Too few qualified professionals, inconsistent quality, inaccessibility, and stigma thwart traditional solutions. Innovations must be scalable, science-based, and timely.

METHODS

We report analysis of coaches' response times to member messages, sentiment shift negative or positive (-1 to +1), machine learning-identified conversation topics, motivational interviewing adherence, and pre-post reductions in member-reported unhealthy days, distress, and presenteeism. The sample consisted of 38 members over a 4-month period who had at least four conversations over a minimum of 14 days. The results describe the innovative solution and illustrate the value delivered to members and organizations.

RESULTS

Data reported includes response time (median <132 sec), sentiment shift (57% positive), motivational interviewing adherence (>95%), as well as pre-post reductions in unhealthy days (25%), and presenteeism (23%).

CONCLUSIONS

There are opportunities to utilize this emerging model of mental health care to address problems associated with traditional models that make them difficult to access and resource-heavy. This study provides data that describes and demonstrates a proof of concept for an innovative technology-enabled service that addresses the problems of scalability, access, quality, and stigma that have long challenged traditional mental health services.

CLINICALTRIAL

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Proposal and Evaluation of Vertical Vibration Theory of Air Caster
Authors: Ito Tetsunoshin , Mehrdad Sadeghzadeh Nazari  , Kazuaki Inaba
Published: July 2024

Urbanization and human development have increased the exposure of seismic risk. Therefore, engineers need to develop new and more efficient technologies to protect people and objects from the disastrous consequences of earthquakes. Air casters have gained attention and have been utilized in the past decade as effective seismic vibration control devices. Although such active isolation systems perform well in mitigating horizontal input vibrations, they might cause excessive rocking motions, if not designed properly. This fact emphasizes the importance of exploring the vertical dynamic properties of air isolation systems. To gain such an understanding, this research examines and proposes a formula for the vertical stiffness and damping of air caster systems. Theoretical solutions to the vertical stiffness and damping of such systems have been explored. Computer simulations considering fluid-structure interaction have also been performed to understand the dynamic behavior of the supporting air layer. Results have been compared to validate the proposed dynamic quantities within the considered simulation range. It is also concluded that the instantaneous air layer thickness, representing the air chamber pressure, and the bearing inlet flow rate are the key factors in determining the dynamic properties of the air layer. It is concluded that to evaluate the performance of the air caster seismic isolation device and increase the probability that the qualified seismic isolation performance will be exhibited, it is necessary to investigate which parameters are greatly involved in the viscous damping coefficient and the spring constant of  amass-spring-damper system equivalent to the air caster isolation system.
A STUDY TO EVALUATE THE TYPE AND CAUSE OF BLINDNESS/LOW VISION IN APPLICATIONS FOR BLINDNESS CERTIFICATE PRESENTING IN CHAMBA DISTRICT OF HIMACHAL PRADESH
Authors: SHARMA SMRITI , NEGI SHALOO , ADITYA KASHYAP
Published: July 2024

Objective: This study aims to assess the prevalence, causes, and socio-economic impacts of visual impairment in the Chamba District of Himachal Pradesh, India. It seeks to identify the major factors contributing to visual disability and the role of literacy and employment status in influencing the lives of the visually impaired.
Methods: A cross-sectional, hospital-based study was conducted over a period of one year, enrolling patients from the outpatient department of ophthalmology who were applying for visual disability certification. The study utilized a randomized sampling method and a semi-structured interview along with an examination form for data collection. Ethical approval was obtained, and the study adhered to ICMR and Helsinki Declaration guidelines. Participants underwent comprehensive ophthalmic evaluations, and data were analyzed using SPSS version 17.0.
Results: Among the 270 participants evaluated, a higher prevalence of visual impairment was observed in males (n=149) compared to females (n=121), particularly within the age group of 21-40 y. The leading causes of visual disability included Corneal Opacity (16.25%), Retinitis Pigmentosa (15.83%), and Congenital Malformation (14.17%). Furthermore, literacy played a crucial role in employment opportunities, with 75.83% of the literate participants being employed, indicating a significant impact on the socio-economic status.
Conclusion: The study highlights the multifaceted nature of visual impairment in the Chamba District, emphasizing the need for integrated public health strategies to address the identified challenges. Enhancing preventive measures, improving access to healthcare, and supporting rehabilitation services are essential steps towards mitigating the burden of visual impairment.
GIANT CELL TUMOUR OF TENDON SHEATH IN THE FOOT: A RARE CASE REPORT
Authors: GIRISH GARG  , MEENA RAGHUVEER , KUMAR SANDEEP , MEENA MAHAVEER
Published: July 2024

Giant cell tumor of the tendon sheath (GCT-TS) is predominantly encountered in the hand, ranking as the second most common solid tumor after ganglion cysts. Contrary to its prevalence in the upper extremity, GCT-TS manifestation in the foot is exceptionally rare. This report delineates a unique presentation of GCT-TS in the foot of a 25 y old female, who presented with a painful, progressively enlarging mass in the lateral aspect of her foot. This case underscores the diagnostic challenges and therapeutic considerations in managing such an atypical presentation of GCT-TS.
EVALUATING THE EFFECTIVENESS OF PERCUTANEOUS PINNING VS. COLLES’ CAST IN UNSTABLE DISTAL RADIUS FRACTURES: A PROSPECTIVE ANALYSIS OF FUNCTIONAL AND RADIOLOGICAL OUTCOME
Authors: BANSAL PUNEET , SHARMA ANURAG , SINGH AMBRISH KUMAR , PRAKASH GYAN , RANA ROHIT
Published: July 2024

Objective: Distal radius fractures are among the most prevalent orthopedic emergencies, significantly impacting patient quality of life. This study aimed to compare the effectiveness of closed reduction with percutaneous pinning (CRPP) versus Colles’ cast application (CRCI) in managing unstable distal radius fractures.
Methods: A prospective, randomized comparative study was conducted at the Department of Orthopaedic Surgery, Indira Gandhi Medical College and Hospital, involving 80 patients with unstable distal end radius fractures. Participants were systematically randomized into two groups for treatment with CRPP or CRCI. Functional and radiological outcomes were assessed using the Mayo Wrist Score, the Modified Gartland and Werley Scoring System, the Green and O’Brien Score, and Sarmiento’s Modification of lindstrom Criteria.
Results: The study found significant improvements in radial length, radial inclination, and volar tilt in the CRPP group compared to the CRCI group. The CRPP group demonstrated superior radiological outcomes and functional recovery metrics, indicating enhanced effectiveness over CRCI in managing unstable distal radius fractures.
Conclusion: Closed reduction with percutaneous pinning offers better radiological alignment and functional recovery than Colles’ cast application in the treatment of unstable distal radius fractures, suggesting it as a preferable treatment strategy.
A CROSS-SECTIONAL SURVEY OF KNOWLEDGE, ATTITUDE AND PRACTICE OF P-DRUG IN A TEACHING HOSPITAL.
Authors: D. P. HOYSALA KUMAR , K. SWETHA
Published: July 2024

Objective: Postgraduates represent the future generation of practitioners and there aren't many studies on the P-drug idea that specifically target them. Hence, we have taken up this study to assess the knowledge, attitude and practice of P-drug among the postgraduates.
Methods: A prospective observational study with a cross-sectional design was conducted at a Tertiary Care Teaching Hospital. Participants' responses were gathered using a pre-validated questionnaire. It evaluated participants' understanding of the P-drug concept, attitudes about P-drugs as treatments for illnesses, and actual P-drug prescribing behaviours. Statistical Package for Social Sciences (SPSS) software version 26 was used to analyze data after compiling data in the Excel sheet.
Results: Out of 230 participants, majority were the females (67.8%). 63% of participants were aware of the “rational use of medicines,” and around 57% of them knew about the P-drug concept. 44.8% were aware of STEP criteria which is applied to select P-drug. Only 66 were practising with the P-drug list and the majority of them opined that teaching programmes are necessary to create awareness about the practice of the P-drug.
Conclusion: It is encouraging that the current study's findings point to reasonable drug usage rather than irrational use. The P-drug idea is a useful instrument for enhancing medical treatment and encouraging ethical drug usage. Furthermore, additional research has to be done to determine how P-drug use affects patient outcomes and healthcare expenditures over the long run.
OCULAR CYSTICERCOSIS: A CASE REPORT
Authors: KASHYAP ADITYA , NEGI SHALOO , SHARMA SMRITI
Published: July 2024

Ocular cysticercosis, though rare, can be extraocular or intraocular. Ocular manifestations usually occur as a part of a systemic infection and can lead to partial or complete visual impairment over a 3-5 y period. The parasite reaches the posterior segment of the eye via the high-flow choroidal circulation through the short ciliary arteries. A 35 y old female patient presented to us with history of blurring of vision in right eye over one week. Fundus examination revealed an oval translucent cyst of about 4 mm in diameter. The patient underwent USG B scan, which revealed well-circumscribed cystic lesion in posterior vitreous.
EFFECT OF BEVEL DIRECTION OF THE ENDOTRACHEAL TUBE ON THE PROPORTION OF CASES DEVELOPING EPISTAXIS DURING NASOTRACHEAL INTUBATION-A RANDOMIZED CONTROLLED INTERVENTIONAL STUDY
Authors: MODI YOGESH CHAND , MENIA NGURANG , JHAWER ANCHAL
Published: July 2024

Objective: Nasotracheal intubation is associated with a number of complications, most commonly nasal trauma or epistaxis. The aim of the study is to determine the effect of conventional versus cephalad direction of the bevel of endotracheal tube on the development of epistaxis during nasotracheal intubation.
Methods: A total of 74 adults aged 18 to 50 y posted for surgeries requiring nasotracheal intubation were randomly divided into group A (Conventional) and group B (Interventional). After induction of anesthesia, in group a bevel direction of thermo softened PVC endotracheal tube was towards the nasal septum in the nasal passage and cephalad in group B, later nasotracheal intubation was completed with direct laryngoscopy and Magill forceps. After five minutes direct laryngoscopy was done to check for presence of epistaxis and its severity. Degree of resistance, nasal passage time, intubation time and haemodynamic parameters (heart rate, blood pressures) were also assessed and compared.
Results: The incidence of epistaxis was significantly lower in group B (Interventional) than group A (Conventional) [15 vs 27; p-value = 0.005], severity of epistaxis [0/1/2] were also significantly lower in group B [22/12/3] than group A [10/15/12] [p value = 0.001]. There was significant difference in haemodynamic parameters between both groups at 1 min till 7 min post intubation. There was no significant difference in degree of resistance, nasal passage time and mean intubation time.
Conclusion: The cephalad direction of the bevel of endotracheal tube in nasal passage during nasotracheal intubation decreases the chances of developing epistaxis and its severity. Hemodynamic parameters are also more stable in cephalad direction.