bluuebunny/crossref_metadata_2025 huggingface dataset:
Age- and Sex-Specific Pediatric Reference Intervals of Serum Electrolytes in Jilin Province of China Using the A Priori Approach
Authors: Zhu Xuetong , Wang Kaijin , Zhou Qi , Guo Wenjia , Jia Yanan , Xu Jiancheng
Published: May 2020

Objectives

The purpose of this study was to establish age- and sex-specific pediatric reference intervals of serum potassium (K), sodium (Na), chlorine (Cl), calcium (Ca), magnesium (Mg), and phosphorus (P) using a direct sampling technique.

Methods

In accordance with the a priori approach, healthy individuals (n = 6,466, aged 1 month to <18 years) were enrolled from five regions in Jilin Province, China, and all analytes were performed in the center laboratory. Reference intervals were divided according to the regression tree and Harris and Boyd’s method, and then they were calculated by the nonparametric rank method. The dynamic changes of reference intervals were evaluated by the lambda-mu-sigma (LMS) method.

Results

Reference intervals of serum Na and Ca were divided into three age-specific partitions. The concentrations of K, Cl, and Mg remained stable with age. However, only dramatic sex-specific changes of P were shown in those 11 to less than 13 years old and 13 to less than 15 years old, with an earlier peak time in females than in males. The correlation between Na and Cl was the strongest among all serum electrolytes (r = 0.31).

Conclusions

Serum electrolyte reference intervals for children and adolescents were established by regression tree, z test, and the LMS method, which provide a more accurate interpretation for diagnosis and prognosis evaluation of clinical pediatric diseases.
Androgenetic Complete Hydatidiform Moles With p57KIP2-Positive Immunostaining
Authors: Usui Hirokazu , Sato Asuka , Ota Masayuki , Ikeda Jun-ichiro , Shozu Makio
Published: May 2020

Objectives

Complete hydatidiform moles (CHMs) are androgenetic and have a high rate of progression to gestational trophoblastic neoplasia (GTN). CHMs are negative when immunostained for p57KIP2 protein, the product of the maternally expressed gene on chromosome 11p15.5, whereas biparental partial hydatidiform moles and hydropic abortion are positive for p57KIP2. This study presents two cases of p57KIP2-positive androgenetic CHMs and explores the cause of this inconsistency.

Methods

Androgenetic CHMs were diagnosed using multiplex short tandem repeat polymorphism analysis. Single-nucleotide polymorphism arrays were performed for molecular karyotyping.

Results

Among the consecutive 188 androgenetic CHMs, two cases were positive for p57KIP2. The first case remitted spontaneously, whereas the second case developed into low-risk GTN. The first case was positive for p57KIP2 in all villi. The karyotype was 48,XX,+7,+11, with the additional chromosome 11 confirmed to be of maternal origin. The second case presented a mosaic of both positively and negatively stained villi. The karyotype was 46,XX.

Conclusions

The cause of one of the CHMs was trisomy with an additional maternal chromosome 11. Although rare, the confirmation of p57KIP2-positive androgenetic CHM status is necessary to manage GTN risk.
Clinical Evaluation and Utilization of Multiple Molecular In Vitro Diagnostic Assays for the Detection of SARS-CoV-2
Authors: Cradic Kendall , Lockhart Marie , Ozbolt Patrick , Fatica Lisa , Landon Lorie , Lieber Michael , Yang David , Swickard Juanita , Wongchaowart Nicholas , Fuhrman Susan , Antonara Stella
Published: May 2020

Objectives

To evaluate the clinical performance of 3 molecular assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods

We used 184 nasopharyngeal swab specimens to compare Abbott ID NOW COVID-19 (Abbott ID NOW), DiaSorin Molecular Simplexa COVID-19 Direct (DiaSorin Simplexa), and Roche cobas 6800 SARS-CoV-2 (Roche cobas) assays. In a separate analysis, 3 specimens (nasopharyngeal, oropharyngeal, and nasal) were collected from 182 unique patients presenting to the emergency department with suspicion of coronavirus disease 2019 and were tested utilizing Abbott ID NOW. To further characterize each assay, relative limits of detection were evaluated utilizing positive nasopharyngeal patient samples.

Results

The positive percent agreement was 91% (95% confidence interval [CI], 0.76-0.97) for Abbott ID NOW and 100% (95% CI, 0.90-1.00) for DiaSorin Simplexa and Roche cobas. The negative percent agreement was 100% (95% CI, 0.98-1.00) for all 3 assays. All swab types tested with the Abbott assay produced concordant results. Polymerase chain reaction assays had approximately 10 to 100 times lower limits of detection than Abbott ID NOW.

Conclusions

Based on these evaluations, a multiplatform testing approach is proposed, depending on patient population and assay sensitivity, to address testing needs during a public health emergency.
Post-stroke deficit prediction from lesion and indirect structural and functional disconnection
Authors: Salvalaggio Alessandro , De Filippo De Grazia Michele , Zorzi Marco , Thiebaut de Schotten Michel , Corbetta Maurizio
Published: May 2020

Behavioural deficits in stroke reflect both structural damage at the site of injury, and widespread network dysfunction caused by structural, functional, and metabolic disconnection. Two recent methods allow for the estimation of structural and functional disconnection from clinical structural imaging. This is achieved by embedding a patient’s lesion into an atlas of functional and structural connections in healthy subjects, and deriving the ensemble of structural and functional connections that pass through the lesion, thus indirectly estimating its impact on the whole brain connectome. This indirect assessment of network dysfunction is more readily available than direct measures of functional and structural connectivity obtained with functional and diffusion MRI, respectively, and it is in theory applicable to a wide variety of disorders. To validate the clinical relevance of these methods, we quantified the prediction of behavioural deficits in a prospective cohort of 132 first-time stroke patients studied at 2 weeks post-injury (mean age 52.8 years, range 22–77; 63 females; 64 right hemispheres). Specifically, we used multivariate ridge regression to relate deficits in multiple functional domains (left and right visual, left and right motor, language, spatial attention, spatial and verbal memory) with the pattern of lesion and indirect structural or functional disconnection. In a subgroup of patients, we also measured direct alterations of functional connectivity with resting-state functional MRI. Both lesion and indirect structural disconnection maps were predictive of behavioural impairment in all domains (0.16 < R2 < 0.58) except for verbal memory (0.05 < R2 < 0.06). Prediction from indirect functional disconnection was scarce or negligible (0.01 < R2 < 0.18) except for the right visual field deficits (R2 = 0.38), even though multivariate maps were anatomically plausible in all domains. Prediction from direct measures of functional MRI functional connectivity in a subset of patients was clearly superior to indirect functional disconnection. In conclusion, the indirect estimation of structural connectivity damage successfully predicted behavioural deficits post-stroke to a level comparable to lesion information. However, indirect estimation of functional disconnection did not predict behavioural deficits, nor was a substitute for direct functional connectivity measurements, especially for cognitive disorders.
Familial adenomatous polyposis in dogs: hereditary gastrointestinal polyposis in Jack Russell Terriers with germline APC mutations
Authors: Yoshizaki Kyoko , Hirata Akihiro , Nishii Naohito , Kawabe Mifumi , Goto Minami , Mori Takashi , Sakai Hiroki
Published: May 2020

Many hereditary disorders in dogs have equivalents in humans and thus attract attention as natural animal models. Breed predisposition to certain diseases often provides promising clues to explore novel hereditary disorders in dogs. Recently, cases of gastrointestinal (GI) polyps in Jack Russell Terriers (JRTs) have increased in Japan. In 21 affected JRTs, polyps were found in either or both the stomach and colorectum, with a predilection for the gastric antrum and rectum. Multiple polyps were found in 13 of 21 examined dogs, including 5 dogs with both gastric and colorectal polyps. Some dogs were found to have GI polyps at an early age, with the youngest case being 2.3 years old. Histopathologically, 43 of 46 GI polyps (93.5%) were diagnosed as adenomas or adenocarcinomas. Immunohistochemical analysis revealed cytoplasmic and nuclear accumulation of β-catenin in the tumor cells. As in the case of human patients with familial adenomatous polyposis, all examined JRTs with GI polyps (n = 21) harbored the identical heterozygous germline APC mutations, represented by a 2-bp substitution (c.[462A>T; 463A>T]). The latter substitution was a non-sense mutation (p.K155X) resulting in a truncated APC protein, thus suggesting a strong association with this cancer-prone disorder. Somatic mutation and loss of the wild-type APC allele were detected in the GI tumors of JRTs, suggesting that biallelic APC inactivation was involved in tumor development. This study demonstrated that despite differences in the disease conditions between human and dog diseases, germline APC mutation confers a predisposition to GI neoplastic polyps in both dogs and humans.
Clinical Characteristics and Outcomes in People Living With Human Immunodeficiency Virus Hospitalized for Coronavirus Disease 2019
Authors: Shalev Noga , Scherer Matthew , LaSota Elijah D , Antoniou Pantelis , Yin Michael T , Zucker Jason , Sobieszczyk Magdalena E
Published: May 2020

We describe the characteristics of 31 people living with human immunodeficiency virus hospitalized for severe acute respiratory syndrome coronavirus 2 infection. All patients were on antiretroviral therapy and virologically suppressed at the time of admission. Clinical course and outcomes were similar to those reported in other hospitalized cohorts.
Predicting Infectious Severe Acute Respiratory Syndrome Coronavirus 2 From Diagnostic Samples
Authors: Bullard Jared , Dust Kerry , Funk Duane , Strong James E , Alexander David , Garnett Lauren , Boodman Carl , Bello Alexander , Hedley Adam , Schiffman Zachary , Doan Kaylie , Bastien Nathalie , Li Yan , Van Caeseele Paul G , Poliquin Guillaume
Published: May 2020

Background

Reverse-transcription polymerase chain reaction (RT-PCR) has become the primary method to diagnose viral diseases, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RT-PCR detects RNA, not infectious virus; thus, its ability to determine duration of infectivity of patients is limited. Infectivity is a critical determinant in informing public health guidelines/interventions. Our goal was to determine the relationship between E gene SARS-CoV-2 RT-PCR cycle threshold (Ct) values from respiratory samples, symptom onset to test (STT), and infectivity in cell culture.

Methods

In this retrospective cross-sectional study, we took SARS-CoV-2 RT-PCR–confirmed positive samples and determined their ability to infect Vero cell lines.

Results

Ninety RT-PCR SARS-CoV-2–positive samples were incubated on Vero cells. Twenty-six samples (28.9%) demonstrated viral growth. Median tissue culture infectious dose/mL was 1780 (interquartile range, 282–8511). There was no growth in samples with a Ct > 24 or STT > 8 days. Multivariate logistic regression using positive viral culture as a binary predictor variable, STT, and Ct demonstrated an odds ratio (OR) for positive viral culture of 0.64 (95% confidence interval [CI], .49–.84; P < .001) for every 1-unit increase in Ct. Area under the receiver operating characteristic curve for Ct vs positive culture was OR, 0.91 (95% CI, .85–.97; P < .001), with 97% specificity obtained at a Ct of > 24.

Conclusions

SARS-CoV-2 Vero cell infectivity was only observed for RT-PCR Ct < 24 and STT < 8 days. Infectivity of patients with Ct > 24 and duration of symptoms > 8 days may be low. This information can inform public health policy and guide clinical, infection control, and occupational health decisions. Further studies of larger size are needed.
New Blind Filter Protocol: An Improved Privacy-Preserving Scheme for Location-Based Services
Authors: Li Zhidan , Li Wenmin , Gao Fei , Yu Ping , Zhang Hua , Jin Zhengping , Wen Qiaoyan
Published: May 2020

Location-based services have attracted much attention in both academia and industry. However, protecting user’s privacy while providing accurate service for users remains challenging. In most of the existing research works, a semi-trusted proxy is employed to act on behalf of a user to minimize the computation and communication costs of the user. However, user privacy, e.g. location privacy, cannot be protected against the proxy. In this paper, we design a new blind filter protocol where a user can employ a semi-trusted proxy to determine whether a point of interest is within a circular area centered at the user’s location. During the protocol, neither the proxy nor the location-based service provider can obtain the location of the user and the query results. Moreover, each type of query is controlled by an access tree and only the users whose attributes satisfy this access tree can complete the specific type of query. Security analysis and efficiency experiments validate that the proposed protocol is secure and efficient in terms of the computation and communication overhead.
Implanted satellite transmitters affect sea duck movement patterns at short and long timescales
Authors: Lamb Juliet S , Paton Peter W C , Osenkowski Jason E , Badzinski Shannon S , Berlin Alicia M , Bowman Tim , Dwyer Chris , Fara Luke J , Gilliland Scott G , Kenow Kevin , Lepage Christine , Mallory Mark L , Olsen Glenn H , Perry Matthew C , Petrie Scott A , Savard Jean-Pierre L , Savoy Lucas , Schummer Michael , Spiegel Caleb S , McWilliams Scott R
Published: May 2020

Studies of the effects of transmitters on wildlife often focus on survival. However, sublethal behavioral changes resulting from radio-marking have the potential to affect inferences from telemetry data and may vary based on individual and environmental characteristics. We used a long-term, multi-species tracking study of sea ducks to assess behavioral patterns at multiple temporal scales following implantation of intracoelomic satellite transmitters. We applied state-space models to assess short-term behavioral patterns in 476 individuals with implanted satellite transmitters, as well as comparing breeding site attendance and migratory phenology across multiple years after capture. In the short term, our results suggest an increase in dispersive behavior immediately following capture and transmitter implantation; however, behavior returned to seasonally average patterns within ~5 days after release. Over multiple years, we found that breeding site attendance by both males and females was depressed during the first breeding season after radio-marking relative to subsequent years, with larger relative decreases in breeding site attendance among males than females. We also found that spring and breeding migrations occurred later in the first year after radio-marking than in subsequent years. Across all behavioral effects, the severity of behavioral change often varied by species, sex, age, and capture season. We conclude that, although individuals appear to adjust relatively quickly (i.e. within 1 week) to implanted satellite transmitters, changes in breeding phenology may occur over the longer term and should be considered when analyzing and reporting telemetry data.
Curation of cancer hallmark-based genes and pathways for in silico characterization of chemical carcinogenesis
Authors: Liang Peir-In , Wang Chia-Chi , Cheng Hsien-Jen , Wang Shan-Shan , Lin Ying-Chi , Lin Pinpin , Tung Chun-Wei
Published: May 2020

Exposure to toxic substances in the environment is one of the most important causes of cancer. However, the time-consuming process for the identification and characterization of carcinogens is not applicable to a huge amount of testing chemicals. The data gaps make the carcinogenic risk uncontrollable. An efficient and effective way of prioritizing chemicals of carcinogenic concern with interpretable mechanism information is highly desirable. This study presents a curation work for genes and pathways associated with 11 hallmarks of cancer (HOCs) reported by the Halifax Project. To demonstrate the usefulness of the curated HOC data, the interacting HOC genes and affected HOC pathways of chemicals of the three carcinogen lists from IARC, NTP and EPA were analyzed using the in silico toxicogenomics ChemDIS system. Results showed that a higher number of affected HOCs were observed for known carcinogens than the other chemicals. The curated HOC data is expected to be useful for prioritizing chemicals of carcinogenic concern.

Database URL: The HOC database is available at https://github.com/hocdb-KMU-TMU/hocdb and the website of Database journal as Supplementary Data.
Comparison of physical activity levels in Spanish people with diabetes with and without cataracts
Authors: López-Sánchez Guillermo F , Sánchez-Castillo Sheila , López-Bueno Rubén , Pardhan Shahina , Zauder Roksana , Skalska Maria , Jastrzębska Joanna , Jastrzębski Zbigniew , Smith Lee
Published: May 2020

Background

The objective was to compare levels of physical activity (PA) in a large sample of Spanish people with diabetes with and without cataracts. To our knowledge, this is the first study comparing PA levels in people with diabetes with and without cataracts in a large representative sample.

Methods

Cross-sectional data from the Spanish National Health Survey 2017 were analyzed (n = 1014 people with diabetes; 43.1% females; age range 15–69 years; mean age 58.4 ± 9.2 years). International Physical Activity Questionnaire (IPAQ) short form was used to measure PA. Total MET-min week−1 of PA were calculated and participants were divided into two categories according to American Diabetes Association PA guidelines: (i) <600 MET-min week−1. (ii) At least 600 MET-min week−1. Diabetes and cataracts were self-reported in response to the questions ‘Have you ever been diagnosed with diabetes/cataracts?’ Participants also reported other variables including age, gender, marital status, living as a couple, education, smoking, alcohol consumption and obesity. Statistical analysis was performed with SPSS 23.0.

Results

The overall prevalence of cataract was 14.0% and the overall prevalence of people doing <600 MET-min week−1 of PA was 35.4%. The prevalence of cataract was significantly lower in those doing more PA (12.1% vs. 17.5%; P = 0.016). Those without cataracts were significantly more active than those with cataracts (1846.8 vs. 1289.4 MET-min week−1; P = 0.001). The adherence to American Diabetes Association PA guidelines was significantly higher in those without cataracts (66.1% vs. 55.6%; P = 0.016).

Conclusions

Interventions to promote PA targeting people with both diabetes and cataracts are warranted.
The Importance of Muscle Versus Fat Mass in Sarcopenic Obesity: A Re-evaluation Using D3-Creatine Muscle Mass Versus DXA Lean Mass Measurements
Authors: Orwoll Eric S , Peters Katherine E , Hellerstein Marc , Cummings Steven R , Evans William J , Cawthon Peggy M
Published: May 2020

Background

The combination of sarcopenia and obesity has been associated with physical impairment in older people. However, previous research has relied on assessments of lean mass as a surrogate for muscle mass. We postulate that inaccurate measures of muscle mass may have obscured the role of obesity in sarcopenia and related outcomes. Our aim was to clarify the interactions of muscle and fat with physical performance and adverse outcomes using an accurate measure of muscle mass.

Methods

In a longitudinal study of >1,300 older men (mean age 84 years), we compared a direct measurement of muscle mass (D3 creatine dilution; D3Cr) with an approximation of muscle mass (appendicular lean mass [ALM] by dual-energy x-ray absorptiometry [DXA]) and their associations with measures of physical performance (gait speed, chair stand time) and adverse outcomes (incident injurious falls and mobility problems). We measured percent fat mass by DXA.

Results

Low D3Cr muscle mass was strongly associated with decreased performance and increased risk of adverse outcomes. Increased fat mass had little association after accounting for D3Cr muscle mass. In contrast, DXA ALM was minimally associated with performance or adverse outcomes, and fatness remained associated with both outcomes after accounting for DXA ALM.

Conclusions

When an accurate assessment of muscle mass (rather than lean mass) is used, reduced muscle mass is highly associated with important outcomes and the negative effects of adiposity are minimal, suggesting that obesity has little relevance for the understanding of important adverse health outcomes of sarcopenia in older men.
Oceanic high-frequency global seismic wave propagation with realistic bathymetry
Authors: Fernando Benjamin , Leng Kuangdai , Nissen-Meyer Tarje
Published: May 2020

We present a new approach to simulate high-frequency seismic wave propagation in and under the oceans. Based upon AxiSEM3D, this method supports a fluid ocean layer, with associated water-depth phases and seafloor topography (bathymetry). The computational efficiency and flexibility of this formulation means that high-frequency calculations may be carried out with relatively light computational loads. A validation of the fluid ocean implementation is shown, as is an evaluation of the oft-used ocean loading formulation, which we find breaks down at longer periods than was previously believed. An initial consideration of the effects of seafloor bathymetry on seismic wave propagation is also given, wherein we find that the surface waveforms are significantly modified in both amplitude and duration. When compared to observed data from isolated island stations in the Pacific, synthetics which include a global ocean and seafloor topography appear to more closely match the observed waveform features than synthetics generated from a model with topography on the solid surface alone. We envisage that such a method will be of use in understanding the new and exciting ocean-bottom and floating seismometer data sets now being regularly collected.
Team Coordination in Uncertain Environments: The Role of Processual Communication Networks
Authors: Pilny Andrew , Dobosh Melissa , Yahja Alex , Poole Marshall Scott , Campbell Aaron , Ruge-Jones Luisa , Proulx Jeff
Published: May 2020

The ways in which teams coordinate are critical to navigating today’s turbulent environment. Communication networks have been theorized to be a key factor for accomplishing team coordination. However, empirical research has largely taken a static approach by viewing communication networks as material, structural arrangements, which we call structural communication networks (SCNs). Informed by network structuration theory, we articulate a complementary approach, called processual communication networks (PCNs), which views communication networks as episodic, dynamic, and sequential. To test this, we conducted a multi-team experiment of 62 teams embedded in a virtual world where their primary objective was to coordinate an attack on a group of insurgents. Using relational event modeling to capture the dynamics of PCNs, we hypothesized and found support for the role of PCNs as a mediator of SCNs and an indicator of structural appropriation. Moreover, highly decentralized PCNs positively predicted coordination, regardless of whether they were faithfully or ironically appropriated.
Why Do People Share Ideologically Extreme, False, and Misleading Content on Social Media? A Self-Report and Trace Data–Based Analysis of Countermedia Content Dissemination on Facebook and Twitter
Authors: Hopp Toby , Ferrucci Patrick , Vargo Chris J
Published: May 2020

Recently, substantial attention has been paid to the spread of highly partisan and often factually incorrect information (i.e., so-called “fake news”) on social media. In this study, we attempt to extend current knowledge on this topic by exploring the degree to which individual levels of ideological extremity, social trust, and trust in the news media are associated with the dissemination of countermedia content, or web-based, ideologically extreme information that uses false, biased, misleading, and hyper-partisan claims to counter the knowledge produced by the mainstream news media. To investigate these possible associations, we used a combination of self-report survey data and trace data collected from Facebook and Twitter. The results suggested that sharing countermedia content on Facebook is positively associated with ideological extremity and negatively associated with trust in the mainstream news media. On Twitter, we found evidence that countermedia content sharing is negatively associated with social trust.
Uterus transplantation: joys and frustrations of becoming a ‘complete’ woman—a qualitative study regarding self-image in the 5-year period after transplantation
Authors: Järvholm Stina , Enskog Anders , Hammarling Catrina , Dahm-Kähler Pernilla , Brännström Mats
Published: May 2020

STUDY QUESTION

How is a women’s self-image affected by uterus transplantation (UTx)?

SUMMARY ANSWER

Women experienced receiving a uterus in both positive and negative ways, but in general, their self-image was positively affected; regardless of whether they have given birth to a child or not, recipients describe themselves as being ‘back to normal’ after the hysterectomy to remove the transplanted uterus.

WHAT IS KNOWN ALREADY

UTx has repeatedly proved to be a successful treatment for absolute uterine factor infertility. However, there has been no previous qualitative long-term research into the self-image of women undergoing UTx.

STUDY DESIGN, SIZE, DURATION

This complete, prospective cohort study included the nine recipients of the first UTxs performed in Sweden mostly in 2013. Interviews took place in the 5 years following surgery.

PARTICIPANTS/MATERIALS, SETTING, METHODS

Eight out of the nine recipients had congenital absence of the uterus, a characteristic of Mayer–Rokitansky–Küster–Hauser syndrome, and one recipient lacked a uterus after a radical hysterectomy due to cervical cancer. The mean age of participants was 31.5 years at inclusion and at this time they all lived in stable marital relationships. Post-transplantation, interviews were performed annually for 5 years, comprising a total of 43 interviews. The interview followed a semi-structured guide. All interviews (median duration of around 25 minutes) were recorded, transcribed verbatim and then analysed by thematic approach.

MAIN RESULTS AND THE ROLE OF CHANCE

The joys and frustrations of becoming a ‘complete’ woman are seen as a master theme, which influences the three underlying subthemes, a changed self-perception, a changed body and a changed sexuality. Each of these subthemes have three underlying categories.

LIMITATIONS, REASONS FOR CAUTION

The small sample size is a limitation.

WIDER IMPLICATIONS OF THE FINDINGS

The results provide information that will be helpful in pre-operative screening procedures and in the psychological support offered both to women who experienced successful and unsuccessful outcomes following UTx.

STUDY FUNDING/COMPETING INTEREST(S)

Funding was received from the Jane and Dan Olsson Foundation for Science; the Knut and Alice Wallenberg Foundation; an ALF grant from the Swedish state under an agreement between the government and the county councils; the Swedish Research Council; a Ferring Pharmaceuticals scholarship in memory of Robert Edwards; and the Iris Jonzén-Sandblom and Greta Jonzén Foundation. The authors have no competing interests.

TRIAL REGISTRATION NUMBER

NCT01844362.
Automatic detection of hand hygiene using computer vision technology
Authors: Singh Amit , Haque Albert , Alahi Alexandre , Yeung Serena , Guo Michelle , Glassman Jill R , Beninati William , Platchek Terry , Fei-Fei Li , Milstein Arnold
Published: May 2020

Objective

Hand hygiene is essential for preventing hospital-acquired infections but is difficult to accurately track. The gold-standard (human auditors) is insufficient for assessing true overall compliance. Computer vision technology has the ability to perform more accurate appraisals. Our primary objective was to evaluate if a computer vision algorithm could accurately observe hand hygiene dispenser use in images captured by depth sensors.

Materials and Methods

Sixteen depth sensors were installed on one hospital unit. Images were collected continuously from March to August 2017. Utilizing a convolutional neural network, a machine learning algorithm was trained to detect hand hygiene dispenser use in the images. The algorithm’s accuracy was then compared with simultaneous in-person observations of hand hygiene dispenser usage. Concordance rate between human observation and algorithm’s assessment was calculated. Ground truth was established by blinded annotation of the entire image set. Sensitivity and specificity were calculated for both human and machine-level observation.

Results

A concordance rate of 96.8% was observed between human and algorithm (kappa = 0.85). Concordance among the 3 independent auditors to establish ground truth was 95.4% (Fleiss’s kappa = 0.87). Sensitivity and specificity of the machine learning algorithm were 92.1% and 98.3%, respectively. Human observations showed sensitivity and specificity of 85.2% and 99.4%, respectively.

Conclusions

A computer vision algorithm was equivalent to human observation in detecting hand hygiene dispenser use. Computer vision monitoring has the potential to provide a more complete appraisal of hand hygiene activity in hospitals than the current gold-standard given its ability for continuous coverage of a unit in space and time.
Digestibility of amino acids, energy, and minerals in roasted full-fat soybean and expelled-extruded soybean meal fed to growing pigs without or with multienzyme supplement containing fiber-degrading enzymes, protease, and phytase
Authors: Kiarie Elijah G , Parenteau Ilona A , Zhu Cuilan , Ward Nelson E , Cowieson Aaron J
Published: May 2020

Indigestible fiber–protein–phytate complexes reduce the feeding value of soy products. We investigated the effects of multienzyme supplement (MES, Victus) on standardized ileal digestibility (SID) of amino acids (AA) and apparent total tract digestibility (ATTD) of energy and minerals in roasted full-fat soybean (FFSB) seeds and expelled-extruded soybean meal (SBM) fed to growing pigs. The crude protein (CP) was 33.4% and 42.8% dry matter (DM) in FFSB seeds and SBM, respectively and corresponding values for crude fat were 17.4% and 11.8% DM. Semi-purified diets with 50% of either FFSB seeds or SBM as the sole source of AA were prepared without or with MES supplying phytase, protease, xylanase, and β-glucanase at 2,200, 8,300, 400, and 100 U/kg of feed, respectively. Diets had TiO2 as an indigestible marker and the ratio of cornstarch to sucrose and corn oil was identical to calculate DE by the difference method. Eight ileal-cannulated barrows (22.1 ± 0.61 kg) were fed diets in a replicated 4 × 4 Latin square design to give eight replicates per diet. The period lasted for 9 d: 5 d for acclimation, 2 d for fecal, and 2 d for ileal digesta samples. There was no (P > 0.05) interaction between soy type and MES or MES effect on SID of AA; SBM had higher (P < 0.05) SID of CP, His, Leu, and Lys. There was no (P > 0.05) interaction between soy type and MES on energy digestibility. The FFSB seeds had higher ATTD of gross energy (GE, 80.2% vs. 76.6%; P < 0.01) than SBM. Pigs fed MES had higher (P < 0.05) ATTD of DM (91.3% vs. 87.7 %), GE (87.5% vs. 82.4%), CP (86.4% vs. 82.9%), crude fat (70.6% vs. 54.9%), Ca (63.2% vs. 60.2%), and P (67.5% vs. 63.2%). In conclusions, differences on AA and energy digestibility in soy products could be linked to processing and compositional differences. Although MES had no effect on SID of AA, the effects on the utilization of minerals and energy demonstrated the value of fiber-degrading enzymes, protease, and phytase in improving the nutritive value of soy products independent of processing.
Separating Predicted Randomness from Residual Behavior
Authors: Apesteguia Jose , Ballester Miguel A
Published: May 2020

We propose a novel measure of goodness of fit for stochastic choice models, that is, the maximal fraction of data that can be reconciled with the model. The procedure is to separate the data into two parts: one generated by the best specification of the model and another representing residual behavior. We claim that the three elements involved in a separation are instrumental in understanding the data. We show how to apply our approach to any stochastic choice model and then study the case of four well-known models, each capturing a different notion of randomness. We illustrate our results with an experimental data set.
General Court confirms rejection of EUTM application for ‘Hickies shoelaces’ due to lack of distinctiveness
Authors: Martin Stefan
Published: May 2020

General Court of the European Union, Case T-573/18 FORM EINES SCHNÜRSENKELS (3D), EU:T:2020:32, 5 February 2020
Development of an Observational Parental Scaffolding Measure for Youth with Spina Bifida
Authors: Winning Adrien M , Stiles-Shields Colleen , Driscoll Colleen F Bechtel , Ohanian Diana M , Crowe Autumn N , Holmbeck Grayson N
Published: May 2020

Objective

To examine the reliability and validity of a new observational measure of parental scaffolding, as well as the impact of parental scaffolding on academic and social outcomes among youth with spina bifida (SB).

Methods

As part of a larger study, 137 families of youth with SB participated in family interaction tasks and self-report questionnaires at the baseline assessment. Teachers also reported on youth’s academic independence and competence, as well as social skills. Guided by previous research and theoretical formulations, a rational approach to measure development was employed whereby maternal and paternal scaffolding composites were created using the Family Interaction Macro-coding System (Holmbeck, Zebracki, Johnson, Belvedere, & Hommeyer (2007). Parent-child interaction macro-coding manual. Unpublished coding system. Chicago: Loyola University Chicago).

Results

The scaffolding measure demonstrated acceptable interrater and scale reliabilities. Additionally, both the maternal and paternal scaffolding composites were significantly associated with scores from self-report questionnaires of parenting behaviors in the expected directions. Maternal scaffolding was positively associated with IQ, academic competence, academic independence, and social self-control in youth with SB, whereas paternal scaffolding was positively associated with social cooperation and social self-control. Differences in scaffolding emerged between mothers and fathers, as well as across demographic variables.

Conclusion

Initial findings support the use of the scaffolding measure. Future research should continue to examine the utility of this scaffolding measure in families of youth with SB.
Sleep Disturbances in Survivors of Pediatric Acute Lymphoblastic Leukemia and Their Siblings
Authors: Russell K Brooke , Merz Erin L , Reynolds Kathleen , Schulte Fiona , Tomfohr-Madsen Lianne
Published: May 2020

Objective

Sleep disturbances have been identified by patients with cancer as common and distressing; however, conflicting evidence about the prevalence of these outcomes exists for survivors of childhood cancers. Additionally, little is known about how the experience of cancer might impact survivor siblings’ sleep. The current study compared the sleep of survivors of acute lymphoblastic leukemia who were 2–7 years off therapy and their siblings to healthy control/sibling dyads.

Methods

Participants (survivors, n = 45; survivor siblings, n = 27; controls, n = 45; control siblings, n = 41; 58% male) aged 8–18 (m = 11.64) completed a 7-day sleep diary and seven consecutive days of actigraphy. Parents (n = 90) completed the Children’s Sleep Habits Questionnaire for each of their children.

Results

No between-group differences were found on measures of sleep diaries or actigraphy. Parents reported that survivor siblings had significantly poorer sleep habits than survivors or controls. For survivors, greater time off treatment and younger age at diagnosis were associated with less total sleep time, more wake after sleep onset, and decreased sleep efficiency via actigraphy.

Conclusion

Sleep across all groups was consistent and below national guidelines. Although the survivor group did not have poorer sleep compared to their siblings or matched controls, within the survivor group, those who were diagnosed at an earlier age and those who were further off treatment had more disrupted sleep. Parent reports suggested that survivor siblings may be at risk for sleep problems.
Duodenocolic fistula by nail ingestion in a child
Authors: Kassegne Iroukora , Kanassoua Kokou Kouliwa , Dossouvi Tamegnon , Amouzou Yawod Efoe-Ga , Sakiye Aboza , Adabra Komlan , Alassani Fousseni , Amavi Ayi Kossigan , Tchangai Boyodi , Mouzou Tabana Essohanam , Dosseh Ekoue David Joseph
Published: May 2020

Unintentional foreign body ingestion is common among children. Normally, these ingested foreign bodies pass spontaneously. Only few of them may lead to complications such as fistula, which requires surgical intervention. We are reporting a case of accidental construction nail ingestion in a 3-year-old male child, for 30 days, without any symptoms. Diagnosis of duodenocolic fistula by construction nail was made on clinical examination and abdominal radiography features. He underwent surgical intervention, with nail removal, dudenal and colic primary closure. The follow-up was uneventful. We recommend emergently retrieval of sharp-pointed and long-ingested foreign bodies like a construction nail. Conservative outpatient management by clinical observation is not appropriate for this kind of foreign bodies. It may lead to complications such as perforation and fistula.
Agreeing to disagree: structuring future capital investment provisions in joint ventures
Authors: Elliott Edgar , D’Costa Lois , Bamford James
Published: May 2020

Prior to entering into any joint venture agreement (JVA), dealmakers should be aware of the options available to resolve future investment disagreements. There are three broad capital investment structures commonly found in joint ventures: (i) standard passmark rules; (ii) non-consent/opt-out; and (iii) sole risk. Within each category, deal practitioners have numerous options to tailor capital investment structures. As much as possible, deal practitioners should contemplate the most likely areas of disagreement, and then tailor the capital investment structures appropriately to ensure that the joint ventures (JV) can manage capital investment decisions in an efficient, value-preserving way.

While it is impossible to establish a formula to determine which specific contractual structures will best accommodate future capital investments in a given JV, companies should weigh various factors to inform their position. We reviewed 40 JVAs to understand various capital investment mechanics and how they differ based on the nature of the venture and owner context. Our research found an extremely diverse array of creative structural work-arounds to address different owner appetites to make future capital investments.

The purpose of this article is to describe, illustrate and provide benchmarks on different mechanics and contractual terms found in joint venture agreements, and to offer guidance as to which future capital investment mechanics should be included in venture agreements.
SDSS-IV MaNGA: spatially resolved star formation in barred galaxies
Authors: Fraser-McKelvie Amelia , Aragón-Salamanca Alfonso , Merrifield Michael , Masters Karen , Nair Preethi , Emsellem Eric , Kraljic Katarina , Krishnarao Dhanesh , Andrews Brett H , Drory Niv , Neumann Justus
Published: May 2020

Bars inhabit the majority of local-Universe disc galaxies and may be important drivers of galaxy evolution through the redistribution of gas and angular momentum within discs. We investigate the star formation and gas properties of bars in galaxies spanning a wide range of masses, environments, and star formation rates using the Mapping Nearby Galaxies at APO galaxy survey. Using a robustly defined sample of 684 barred galaxies, we find that fractional (or scaled) bar length correlates with the host’s offset from the star formation main sequence. Considering the morphology of the Hα emission we separate barred galaxies into different categories, including barred, ringed, and central configurations, together with Hα detected at the ends of a bar. We find that only low-mass galaxies host star formation along their bars, and that this is located predominantly at the leading edge of the bar itself. Our results are supported by recent simulations of massive galaxies, which show that the position of star formation within a bar is regulated by a combination of shear forces, turbulence, and gas flows. We conclude that the physical properties of a bar are mostly governed by the existing stellar mass of the host galaxy, but that they also play an important role in the galaxy’s ongoing star formation.
High-redshift JWST predictions from IllustrisTNG: II. Galaxy line and continuum spectral indices and dust attenuation curves
Authors: Shen Xuejian , Vogelsberger Mark , Nelson Dylan , Pillepich Annalisa , Tacchella Sandro , Marinacci Federico , Torrey Paul , Hernquist Lars , Springel Volker
Published: May 2020

We present predictions for high redshift (z = 2−10) galaxy populations based on the IllustrisTNG simulation suite and a full Monte Carlo dust radiative transfer post-processing. Specifically, we discuss the H α and H β + $[\rm O \,{\small III}]$ luminosity functions up to z = 8. The predicted H β + $[\rm O \,{\small III}]$ luminosity functions are consistent with present observations at z ≲ 3 with ${\lesssim} 0.1\, {\rm dex}$ differences in luminosities. However, the predicted H α luminosity function is ${\sim }0.3\, {\rm dex}$ dimmer than the observed one at z ≃ 2. Furthermore, we explore continuum spectral indices, the Balmer break at 4000 Å; (D4000) and the UV continuum slope β. The median D4000 versus specific star formation rate relation predicted at z = 2 is in agreement with the local calibration despite a different distribution pattern of galaxies in this plane. In addition, we reproduce the observed AUV versus β relation and explore its dependence on galaxy stellar mass, providing an explanation for the observed complexity of this relation. We also find a deficiency in heavily attenuated, UV red galaxies in the simulations. Finally, we provide predictions for the dust attenuation curves of galaxies at z = 2−6 and investigate their dependence on galaxy colours and stellar masses. The attenuation curves are steeper in galaxies at higher redshifts, with bluer colours, or with lower stellar masses. We attribute these predicted trends to dust geometry. Overall, our results are consistent with present observations of high-redshift galaxies. Future James Webb Space Telecope observations will further test these predictions.
Characterizing brown dwarf companions with IRDIS long-slit spectroscopy: HD 1160 B and HD 19467 B
Authors: Mesa D , D’Orazi V , Vigan A , Kitzmann D , Heng K , Gratton R , Desidera S , Bonnefoy M , Lavie B , Maire A-L , Peretti S , Boccaletti A
Published: May 2020

The determination of the fundamental properties (mass, separation, age, gravity, and atmospheric properties) of brown dwarf companions allows us to infer crucial informations on their formation and evolution mechanisms. Spectroscopy of substellar companions is available to date only for a limited number of objects (and mostly at very low resolution, R < 50) because of technical limitations, i.e. contrast and angular resolution. We present medium resolution (R = 350), coronagraphic long-slit spectroscopic observations with SPHERE of two substellar companions, HD 1160 B and HD 19467 B. We found that HD 1160 B has a peculiar spectrum that cannot be fitted by spectra in current spectral libraries. A good fit is possible only considering separately the Y+J and the H spectral band. The spectral type is between M5 and M7. We also estimated a Teff of 2800–2900 K and a log g of 3.5–4.0 dex. The low surface gravity seems to favour young age (10–20 Myr) and low mass (∼20 MJup ) for this object. HD 19467 B is instead a fully evolved object with a Teff of ∼1000 K and log g of ∼5.0 dex. Its spectral type is T6 ± 1.
Venom Systems as Models for Studying the Origin and Regulation of Evolutionary Novelties
Authors: Zancolli Giulia , Casewell Nicholas R
Published: May 2020

A central goal in biology is to determine the ways in which evolution repeats itself. One of the most remarkable examples in nature of convergent evolutionary novelty is animal venom. Across diverse animal phyla, various specialized organs and anatomical structures have evolved from disparate developmental tissues to perform the same function, that is, produce and deliver a cocktail of potent molecules to subdue prey or predators. Venomous organisms therefore offer unique opportunities to investigate the evolutionary processes of convergence of key adaptive traits, and the molecular mechanisms underlying the emergence of novel genes, cells, and tissues. Indeed, some venomous species have already proven to be highly amenable as models for developmental studies, and recent work with venom gland organoids provides manipulatable systems for directly testing important evolutionary questions. Here, we provide a synthesis of the current knowledge that could serve as a starting point for the establishment of venom systems as new models for evolutionary and molecular biology. In particular, we highlight the potential of various venomous species for the study of cell differentiation and cell identity, and the regulatory dynamics of rapidly evolving, highly expressed, tissue-specific, gene paralogs. We hope that this review will encourage researchers to look beyond traditional study organisms and consider venom systems as useful tools to explore evolutionary novelties.