bluuebunny/crossref_metadata_2025 huggingface dataset:
Actividad antioxidante e inhibidora in vitro de la enzima HMGCoA reductasa del extracto metanólico de Jatropha Gossypifolia.
Authors: Bohórquez Moreno Cristina , Duran Lengua Marlene , Alviz Amador Antistio
Published: January 2021

Introducción: la Jatropha gossypifolia es una planta tradicionalmente utilizada como agente antidiabético e hipolipemiante. Por tanto, es importante evaluar la actividad antioxidante e inhibidora de la enzima HMG CoA reductasa, para validar su uso tradicional. Objetivo: determinar la actividad inhibidora in vitro de la enzima reductasa HMG- CoA y la actividad antioxidante del extracto metanólico de Jatropha gossypifolia. Metodología: se evaluó la inhibición de la 3-hidroxi-3-metilglutaril-coenzima A reductasa (HMG-CoA) usando el kit de ensayo HMG-CoA reductasa (HMGR) de sigma Aldrich, la actividad antioxidante se realizó mediante la inhibición de hemólisis de los glóbulos rojos expuestos a H2O2. Los resultados se analizaron mediante análisis de varianza, aceptando significancia estadística con p <0,05. Resultados: el extracto metanólico total de Jatropha gossypifolia a diferentes concentraciones inhibió la enzima HMG-coA reductasa, especialmente a la concentración de 0.001 ppm, donde inhibió alrededor del 76.5% podría estar asociado a metabolitos secundarios de alta polaridad. Además, se evidenció que una concentración de 0.1 ppm de extracto inhibió el 96.6% de la hemólisis en eritrocitos humanos inducida por H2O2 (p <0.001). Conclusiones: el extracto de metanol total de Jatropha gossypifolia a diferentes concentraciones inhibe la enzima HMG-coA reductasa y tiene actividad antioxidante a bajas concentraciones.
Caracterización epidemiológica y microbiológica, mediante cultivo de biopsia, de los casos de úlceras venosas sobreinfectadas en el Hospital Universitario del Caribe.
Authors: Lozano Bretón Camilo Eduardo , Ramírez Barakat Efraín Augusto , Cuadrado Cano Bernarda
Published: January 2021

Introducción: las úlceras venosas son una manifestación de insuficiencia venosa severa, con capacidad para deteriorar la calidad de vida. La sobreinfección es una complicación frecuente y genera altos costos al sistema de salud, estancias hospitalarias prolongadas y otras complicaciones, incluyendo el aumento de la resistencia microbiana debido a que no se ha establecido cuál es el estudio ideal para identificar el germen causal, y por ende, son procesos manejados con esquemas empíricos. Objetivo: caracterizar epidemiológica y microbiológicamente, mediante cultivo de biopsia, los casos de úlceras venosas sobreinfectadas en el Hospital Universitario del Caribe (H.U.C.). Métodos: diseño descriptivo, corte transversal, prospectivo. Se tomaron pacientes mayores de 18 años los cuales presentaban úlceras venosas sobreinfectadas y hospitalizados en el H.U.C. Se obtuvo mediante encuesta información sociodemográfica, clínica y paraclínicos; con toma de muestras por biopsia para estudio microbiológico. Se realizó análisis univariado y bivariado. Resultados: se obtuvieron 53 pacientes, 29 hombres (54.7%) y 24 mujeres (45.3%), con promedio de 60,5 ± 14,6 años. Hubo una prevalencia de hipertensión en 35 pacientes (66%), diabetes mellitus 26 (49.1%), tabaquismo 17 (32.1%) y enolismo 14 (26.4%). Los síntomas más frecuentes fueron eritema (83.0%), dolor (79.2%) y edema (79.2%). En 56.6% de los casos se aisló Staphylococcus aureus aunque fueron frecuentes los resultados polimicrobianos. Conclusiones: la prevalencia de úlceras venosas es mayor en el sexo masculino, en las cuales, el microorganismo más frecuentemente aislado es S. aureus, aunque se obtuvieron perfiles polimicrobianos. Deben realizarse más estudios para un mayor conocimiento de las características sociodemográficas y microbiológicas de estos pacientes.
Prevalencia de infecciones vaginales en mujeres embarazadas y no embarazadas en un hospital de Cali, Colombia.
Authors: Chávez Vivas Mónica , García Blanco Laura , Chaves Sotelo Jenny , Duran Katherine , Ramírez Jeniffer
Published: January 2021

Introducción: las infecciones vaginales son frecuentes en todos los grupos de edad, pueden presentar una manifestación asintomática, compromiso local o sistémico. Objetivo: establecer la prevalencia de infecciones vaginales en mujeres embarazadas y no embarazadas que consultaron a un hospital de mediana complejidad de la ciudad de Cali. Métodos: se realizó un estudio descriptivo y retrospectivo basado en los reportes de las historias clínicas de pacientes con diagnóstico de vulvovaginitis infecciosa durante un período de un año. Las variables fueron evaluadas estadísticamente para determinar su grado de significancia en la patología.. Resultados: se encontraron 534 registros con una edad promedio de 24 años (DS=10,553; edad min=14 años, máx.= 80 años) entre las mujeres que consultaron por infección vaginal. La vaginosis bacteriana fue más prevalente con un 18.5%, seguida de la vaginitis candidiásica (15.7%). Las mujeres diagnosticadas con vaginitis candidiásica presentaron un mayor riesgo de desarrollar hemorragias (1.1 %; OR: 3.436; p=0.016) y neoplasias (2.4%; OR 2.278; p=0.014). Las mujeres diagnosticadas con vaginosis bacteriana se relacionaron con un mayor riesgo de desarrollar enfermedad inflamatoria pélvica (2.2%; OR: 28.286). La prevalencia de mujeres embarazadas con infecciones vaginales fue del 20.8%, siendo la vaginitis candidiásica el motivo por el cual consultaron con mayor frecuencia. Conclusiones: en este estudio se demostró que las infecciones vaginales afectan a las mujeres en edades reproductivas y sus principales complicaciones derivan en la enfermedad inflamatoria pélvica, hemorragias y neoplasias; con predominio de la vaginosis bacteriana, especialmente, en mujeres de estratos socio-económicamente bajos como es nuestro grupo de estudio.
Consulta pediátrica prenatal : objetivos y beneficios.
Authors: Correa Jiménez Oscar , Camacho Lindo Ángela
Published: January 2021

En los últimos años, la pediatría ha volcado su foco de atención del niño en forma individual a la atención en salud este en el contexto familiar (1). En este orden de ideas, entre más temprano se dé la interacción pediatra-padres se verá afectada positivamente la atención en salud del niño. De otro lado, el pediatra en conjunto con el obstetra debe estar involucrados en la orientación a los padres para la realización de una elección informada sobre los cuidados de su futuro hijo (2). Debido a los beneficios que le han sido demostrados, y que en esta revisión desglosaremos, la Academia Americana de Pediatría desde 1996(3) ha recomendado la consulta pediátrica prenatal. Dado que, en nuestro medio, como en otros países de Latinoamérica (4), la consulta pediátrica prenatal no es objeto de práctica común, se realiza el presente artículo de reflexión con el fin de contextualizar en qué consiste este tipo de consulta, así como sus objetivos y beneficios.
有优化设备制造工艺缩短压力容器制造工期的方案分析
Authors: 黄 家刚
Published: January 2021

在大型化工装置建设过程中，设备能否按时到货是考核施工进度的关键节点，建设方都加大了设备的催交力度，只有打破制造厂固化的生产模式，优化设备制造工艺，重视制造过程质量控制才是缩短压力容器制造工期的出发点。
高铁隧道施工中湿喷混凝土施工技术
Authors: 马 斌
Published: January 2021

在经济高速发展的今天高铁建设速度逐渐加快，其中高铁工程施工过程中隧道工程是其中的重点，因此应合理的选用施工技术。目前湿喷混凝土施工技术在高铁隧道工程中得到了广泛的应用，在使用后可以提高隧道最初支护施工效果并可以保证工程建设速度，同时在使用后可以降低高铁隧道工程施工成本，在与干喷施工工艺相比后湿喷混凝土施工技术优势更加明显，可以得到预期施工效果。高铁工程建设企业在应用此项技术进行隧道施工时应综合考虑施工材料、技术及设备使用要点，确保可以满足施工标准，从而提升高铁工程整体建设质量，促进我国铁路交通行业发展。
香樟的移植与养护管理技术
Authors: 陈 建良
Published: January 2021

香樟是优良的绿化树、行道树及庭荫树，产于中国南方及西南各省区。香樟树对氯气、二氧化硫、臭氧及氟气等有害气体具有抗性，能驱蚊蝇，能耐短期水淹，稍耐荫;喜温暖湿润气候，但耐寒性不强，是园林绿化的首选品种。目前有很多地区都有引进种植，但是由于气候、土壤等因素的不同，种植的效果并不理想。即使在盛产的沪苏浙地区，在移植时考虑不周，养护时观察不够，也会出现生长不良甚至死亡的现象，本篇文章将就香樟移植和养护时常出现的一些情况进行整理和总结。
压力容器检验中无损检测技术的应用
Authors: 杨 舸
Published: January 2021

无损检测技术是现如今最为先进的一种检测技术，其实质就是在保证不会对压力容器造成任何损害的前提下，借助最先进的科学技术或者是仪器设备来对压力容器内层或者是表层结构的完整性进行检测。就现如今实际情况来说，无损检测技术通常都是以物理或者是化学的方式为核心进行检测工作的，压力容器因为自身受到外界多方面因素的影响，所以压力容器的检测需要使用到的无损检测技术往往都是以射线或者是超声波的形式为主，各个无损检测技术在实际运用的过程中所侧重的重心也是存在一定的差异的。鉴于此，这篇文章主要针对海洋石油QK17-2平台的设备中的压力容器检验中无损检测技术的实践运用展开全面深入的研究分析，希望能够对我国压力容器检测工作的良好发展起到积极的影响作用。
高速公路监理合同管理现状分析和优化策略
Authors: 尹 鲲鹏
Published: January 2021

近年来，我国社会经济水平得到快速的提升，从而带动了各个领域的快速发展壮大。为了能够为社会的稳步持续发展创造良好的动力基础，人们对高速公路工程项目提出了更高的要求。要想保证高速公路各项施工工作都能够达到规定的标准，那么就需要项目参与方签署合同，对各项工作给予规范性的约束。全面的落实高速公路监理合同管理工作，结合业主、施工单位以及监理机构之间所存在的经济关系，通过对高速公路项目实施全面的管控，从而对整个工程项目的施工质量加以保证，尽可能的规避各类风险的发生，提升各项工作的效率和效果。因为受到以往传统管理理念的影响，当下我国高速公路监理合同管理工作整体水平还没有达到成熟的状态，所以我们还需要对监理合同管理工作进行进一步的完善，才可以为高速公路工程领域的良好发展起到辅助作用。
浅析水库运行管理及调度的有效方法
Authors: 孙 涛
Published: January 2021

在我国社会经济飞速发展的带动下，使得国内各个行业都得到了良好的发展壮大，在这个过程中水库工程起到了至关重要的作用，特别是在农业生产领域中，发挥出了积极的辅助作用。水库工程不但与社会发展密切相关，并且还与民众生活和人身、财产安全存在直接的关系。我国大部分的水库都在上世纪建造的,实际运用过程中起到了重要的影响作用，但是因为受到多方面因素的影响，所以如果发生任何的事故问题那么必然会引发严重的损失。近年来，各个地区都针对水库运行管理工作制定了管理制度，有效的控制了危险事故的发生，加大力度落实水库运行管理工作是避免水库事故的关键，并且也是确保水库工程能够获得更多效益的基础。
建筑工程地下室结构设计分析
Authors: 陈 婷婷
Published: January 2021

在社会经济快速发展的带动下，使得我国各个行业都得到了全面的发展进步，有效的促进了民众生活水平的不断提升，带动了城市建设工作的全面开展。在建筑工程结构中，地下室结构是较为重要的一个部分，地下室结构的稳定性往往与整个工程整体稳定性密切相关，所以我们务必要对地下室结构设计工作加以重点关注。地下室结构设计工作与上层建筑设计相对比来说，设计会遇到诸多的困难，设计工作人员务必要确保结构设计具有良好的实用性，才能从根本上对工程施工质量加以保证。鉴于此，这篇文章主要针对建筑工程地下室结构设计展开全面深入的分析研究，希望能够对我国建筑工程行业的稳步持续发展有所帮助。
浅谈测绘内业编图心得体会
Authors: 于 海涛
Published: January 2021

随着社会的发展，科学技术的不断创新，航测数字化成图已经成为了现代化地形图制作的主要方式，在航测数字化成图的工作中，地形图内业编辑是最后的一个环节，也是一个工作中作业要求相对较多的过程。文中结合作者工作经验，总结一些内业编图中的心得体会。
水工环的现状及实现水工环地质分析与研究
Authors: 蔡 海涛
Published: January 2021

近年来，我国加大了对外经济开放的力度，从而促进了我国社会经济水平的显著提升，为各个行业的发展壮大带来了诸多的机遇，在这个过程中水工环工作起到了非常重要的影响作用。保证各项水工环工作的有序开展，能够起到良好的保护环境的作用，并且还能够确保人类社会与生态环境和谐共存。但是就水工环发展情况来看，地质勘测工作的实施，因为受到多方面因素的影响，从而会导致地质勘查工作整体效果较差的不良后果，最终会对我国社会和谐稳定发展形成了诸多的限制。鉴于此，这篇文章主要针对水工环工作展开全面深入的研究分析，希望能够对我国整体综合国力的提升有所帮助。
建筑工程施工中深基坑支护的施工技术管理探析
Authors: 高 宁波
Published: January 2021

近年来，我国综合国力在多方面利好因素的影响下，得到了全面的提升，从而为城市建设工作的全面实施带来了良好的机遇，使得城市人口数量不断增加，这样就对房屋建筑提出了更高的要求。为了能够满足社会发展和民众生活的需要，大量的高层建筑应时而生，切实的缓解了当前土地资源匮乏的问题。在实际组织实施高层建筑工程施工工作的时候，深基坑施工技术在其中起到了重要的影响作用，其在保证高层建筑结构整体稳定性方面也具有良好的作用。但是因为各个地区的地质结构存在明显的差别，所以地下环境也是不同的，在组织开展深基坑施工工作的过程中，往往会遇到诸多不良因素的影响，为了确保施工工作的效率和质量，需要综合各方面实际情况来挑选适合的深基坑支护施工技术，切实的为各项施工工作的高效有序开展创造良好的基础，确保深基坑工程施工工作的质量。
UHPC混凝土预制桥面板流水线
Authors: 刘 辉
Published: January 2021

随着我国新型城镇化的逐步推进，越来越多的装配式桥梁走进人们视野，新型的钢-混凝土组合式桥梁正是其中的典型代表，它除具有标准化设计、工厂化生产、装配化施工等一系列优点外，更因节约场地、快速施工等优点在国内推行。装配式预制桥梁已经在国外的桥梁工程中得到广泛应用，发展装配式桥梁结构是建设工业化的必由之路。
探析重力杠杆式起重吊钩防脱钩装置检验中的应用
Authors: 董 严松 , 邢 兆雷
Published: January 2021

随着科技的进步，我国的经济近些年得到质的飞跃。在各种大型工程中，起重机往往扮演着非常重要的角色。文章通过对重力杠杆式起重吊钩防脱钩装置进行分析，并结合实际对起重吊钩防脱钩装置检验提出个人观点，希望为关注重力杠杆式起重吊钩防脱钩装置的人群带来参考。
Synthesis of control system with guaranteed accuracy for unmanned aircraft
Authors: Збруцький О.В. , Довгополий А.С. , Кописов О.Е. , Білобородов O.O.
Published: January 2021

Unmanned aerial vehicle must be controllable and fend off disturbing influences. The quality and effectiveness of fulfilling these tasksare completely determined by the instrumentation system and the software of the control system, which ensures the safety and reliability of the unmanned aerial vehicle. The synthesis of adaptive control algorithms in the presence of disturbances in most cases suggests the use of a certain disturbance model and is associated with the use of integral regulators, which increases the order of the system, and sometimes they are substantially non-linear. Adaptive algorithms use both predictive methods for assessing the dynamics of an object. For the synthesis of the control system, was considered the dynamic model of an unmanned aerial vehicle as a solid. Then the linearized equations of transverse motion can be represented by a system of differential equations. The study performed the synthesis of control system regulators by integrating the equations of the dynamic model of the object for a given control program, made a forecast of the movement of an unmanned aerial vehicle for a certain final period of time. By optimization of program control, was taking into account the restrictions imposed on the control and adjustable variables, the adjustable variables of the forecasting model approach the corresponding control signals on the forecast horizon. At the calculation step, which is a fixed small part of the forecast horizon, the optimal control found was realized and the actual state of the unmanned aerial vehicle was measured at the end of the step. The forecast horizon moves forward one step, and this procedure is repeated. The efficiency of the model predictive control as synthesis method for unmanned aerial vehicle’s control system is analyzed. A new synthesis method of adaptive control system with guaranteed accuracy under an arbitrary external disturbance is shown. The method is based on evaluating the effect of disturbances, predicting the behavior of the system and compensating the impact on the control object by the formation of a law for changing the parameters of the additional controller, which does not directly affect the quality of the control system.The results of control system’s mathematical modeling for aircraft and multicopter types of unmanned aerial vehicles are presented.
Educational Values in the Kaba Minangkabau Text "Anggun Nan Tongga Si Magek Jabang"
Authors: Ita Khairani  , Andin Nur Sinaga
Published: January 2021

This study aims to determine the values of education in the text of the Minangkabau Kaba Manuscript "Anggun Nan Tongga Si Magek Jabang" with the study of sociology of literature. The type of research used is qualitative research with descriptive research methods. The purpose of this study was to describe the values of education in Kaba Minangkabau "Anggun Nan Tongga Si Magek Jabang". The data collection technique used to obtain data was by searching for literature and analyzing the story of Kaba Minangkabau "Anggun Nan Tongga Si Magek Jabang". From the research results, it is obtained the values of religious, moral, social and cultural education. Educational values that really dominate are the values of religious and moral education. From the results of data analysis, Kaba Minangkabau was not only a public entertainment at its time.
Symbolic Meaning in Traditional Badudus Pangantin Banjar
Authors: Kamariah  , Nanda Saputra
Published: January 2021

This research examines the cultural symbols used in the badudus pangantin Banjar custom. The approach used is a cultural semiotics approach. namely studies that emphasize the symbols of a culture. The method used is descriptive analysis method. The primary data source was obtained from four resource persons in the Peat District, aged 60-75 years. Data collection techniques are in the form of (1) observation, (2) interviews, (3) recording, (4) recording. The data analysis technique used is descriptive qualitative. The results of this study show that the symbolic meanings of the Banjar bridal shower custom are as follows: a. symbol of baras longitude, banana, spray three times, tapih, mayang, banyu prayer, candle, carmin, bamantra oil, white porridge, black porridge and pupur with the meaning of a blessed life bride, b. palm symbol, starting with the right, and kambang malati, meaning good behavior. c. symbol of baras lakatan, habang sugar and hintalu with the meaning of living together.
Asociación bidireccional entre periodontitis y diabetes mellitus tipo 2: una revisión de literatura
Authors: Jiménez Palacios Miguel Angel , Alejandro Cumbicus Jefferson Manuel , Romero Espinoza Katherine Andrea
Published: January 2021

El vínculo que tiene la periodontitis con enfermedades sistémicas como la diabetes mellitus tipo 2 (DM2) se ha venido estudiando desde hace mucho tiempo. La evidencia actual sugiere que los mecanismos que subyacen a dicho vínculo están relacionados con los mediadores inflamatorios presentes en ambas enfermedades, y señala que además ambas enfermedades representan un factor de riesgo de manera mutua para desarrollar cada enfermedad, respectivamente. Asimismo, se ha estudiado ampliamente el impacto que puede tener el tratamiento periodontal sobre la DM2, lo cual pude desarrollar nuevas pautas de tratamiento para esta enfermedad metabólica. Sin embargo, actualmente dicha situación no está muy clara pese a los estudios clínicos que se han realizado. Se sugiere que dicho tratamiento puede mejor el control glucémico y disminuir complicaciones relacionadas con la diabetes. El objetivo de la presente revisión es informar sobre los posibles mecanismos fisiopatológicos que relacionan de forma bidireccional a DM2 con la periodontitis. De igual manera, abordar de forma general el efecto que puede tener el tratamiento periodontal sobre el control de la DM2.
Análise dos potenciais medicinais do cajueiro (Anacardium occidentale Linn): uma breve revisão
Authors: Novaes Thiago Emanuel Rodrigues , Novaes Ana Selia Rodrigues
Published: January 2021

A Anacardium occidentale Linn, conhecida popularmente como cajueiro, é uma espécie vegetal nativa do nordeste do Brasil. Dentre seus usos, pode-se destacar o medicinal, em processos terapêuticos e curativos. O objetivo deste estudo é discorrer acerca dos potenciais medicinais do cajueiro na medicina popular nordestina, analisando suas propriedades e principais usos pela população. Trata-se de uma breve revisão de literatura que se utilizou de estudos publicados entre 2002 e 2020, disponíveis na base de dados Google Acadêmico, as buscas se fizeram a partir das palavras-chave “Anacardium occidentale L.”, “Anacardium occidentale L. caatinga”, “Anacardium occidentale L. etnobotanica” e “Anacardium occidentale L. medicinal”. Dos 30 trabalhos selecionados, 10 foram eleitos segundo critérios de inclusão para comporem o presente artigo. Os estudos indicam potenciais para tratamento e/ou cura de ferimentos, inflamações, infecções e problemas gastrointestinais, principalmente, em razão de propriedades derivadas de seus metabólitos secundários. Além disso, evidencia-se a necessidade da realização de mais estudos voltados à temática, visando o fortalecimento das pesquisas etnobotânicas do Brasil.
A usabilidade de novas tecnologias “Up Ferida” para o monitoramento de pacientes diabéticos com feridas na Atenção Básica: Um estudo prospectivo
Authors: Galvão Ailton Mota do Nascimento , Dalbon Viviane Araujo , Mota Louise Maria Lúcio de Araújo , Moura Felipe Roberto Eloi , Magalhães Aruska Kelly Gondim , Menezes Adeline Soraya de Oliveira da Paz , Miranda Renata da Silva , Albuquerque Hevany Braga de Carvalho , Barbosa Ana Paula Fernandes , Silva Zenaldo Porfirio da , Rodrigues Célio Fernando de Sousa , Santana Antonio Euzebio Goulart , Pitta Guilherme Benjamin Brandão
Published: January 2021

Foi realizada uma prospecção tecnológica para avaliar a usabilidade de novas tecnologias para o monitoramento de feridas na Atenção Básica. Patentes e artigos científicos foram buscados nas bases WIPO, PATENTINSPIRATION, LATIPAT - ESPACENET, Science Direct, e Scopus, respectivamente. A busca na base WIPO, utilizando o termo “monitoring and diabetic” no campo “página de cobertura” e a opção “nome” PCT, gerou a recuperação de 460 patentes. Foram recuperadas 0 (0%) patentes na base LATIPAT-SPACENET quando utilizado o termo “monitoring and diabetic” no campo “pesquisa inteligente". Na base PATENTINSPIRATION utilizando o termo “monitoring and diabetic” 1.653 patentes recuperadas lidas na íntegra “título” e “resumo” com código IPC e CPC A61, B1/00, porém, nenhuma se refere ao desenvolvimento de aplicativos para o monitoramento de pacientes diabéticos com feridas na atenção básica, indicando o ineditismo do tema proposto em se tratando de patentes depositadas no Brasil e via PCT.
Como a estrutura de capital afeta o desempenho empresarial e a criação de valor: um estudo de caso de frigorífico brasileiro no período de 2008 a 2015
Authors: Mannarelli Filho Téucle , Mannarelli Lívia Barbosa
Published: January 2021

O estudo tem como objetivo verificar de que maneira a Estrutura de Capital afeta o Desempenho Empresarial e Criação de Valor em de uma empresa brasileira, do setor frigorífico e de carnes, com atuação a nível global, de capital aberto e com suas ações negociadas na Bolsa brasileira B3, por meio de Análise de Demonstrações Financeiras, no período compreendido de 2008 até 2015. A pesquisa foi realizada com base nos dados coletados na Economática, foram feitos os ajustes de deflação e posteriormente calculados os principais Índices e Indicadores Financeiros da empresa, com base em seu Balanço Patrimonial, Demonstrativo de Resultados e Fluxo de Caixa. Utilizou-se Análise Horizontal, Análise Vertical e o cálculo dos índices: Liquidez, Lucratividade, Rentabilidade, Endividamento; sendo focada para entender como a Estrutura de Capital afeta o Desempenho Empresarial e a Criação de Valor. O estudo permite concluir que a forma inadequada na estrutura de capital da empresa no período de análise, realizada com um grande endividamento em 2010 e 2011, somente garante a empresa uma boa liquidez e capacidade de pagamento de curto prazo; e não consegue agregar valor econômico, nem desempenho empresarial.
Investigation of the Light Yield Distribution in LYSO Crystals by the Optical Spectroscopy Method for the Electromagnetic Calorimeters of the COMET Experiment
Authors: Kalinnikov V. , Velicheva E. , Grabtchikov A. , Khodasevich I. , Orlovich V. , Kuno Y. , Sato A.
Published: January 2021

The distribution of the light yield and luminescence intensity along LYSO:Ce crystal length is investigated. These distributions, determined by different defects and emission centers of the dopant in the crystalline structure and its distribution along the length, is measured by two methods: the gamma spectroscopy using radiation sources and the optical spectroscopy using ultraviolet sources. It is shown that crystals have considerable variation of the light yield and luminescence intensity both over the length of an individual crystal (in the growing direction) and for different crystals. It is established that the correction factors for the segmented calorimeter of the COMET experiment can be obtained using optical spectroscopy methods. Consideration of the correction factors will significantly reduce an error of energy measurement in a segmented calorimeter during data handling.
Neutron and Neutron-Breeding Medium Interaction Process Description Within the Physical Birth-and-Death Model
Authors: Korbut T. N. , Bobkova M. V. , Rudak E. A. , Zubets I. A.
Published: January 2021

Analytic methods for nuclear reactor physics problems are still of current interest. They allow the physical interpretation to be obtained for studied processes within simple mathematical apparatus. This work proposes a new approach of neutron and neutronbreeding medium interaction process description based on birth-and-death model. This approach was named the physical birth-and-death model. The equations for the main kinetic characteristic are presented and reactivity values are estimated for two subcritical nuclear assemblies: MASURCA and KUCA.
Uptake of p-Nitrophenol (PNP) from model aqueous solutions using raw and quaternised Afromomum melegueta peels
Authors: Ndiritu J. , Mwangi I W. , Murungi J. I. , Wanjau R. N.
Published: January 2021

Anthropogenic activities contribute large amounts of pollutants to the environment which threaten animal and human health. There is increased realization of the effect of these toxins on surface and ground water, consequently, their elimination is vital in rendering secure water for drinking as well as culpable release of effluents to our habitats. Phenolic compounds cause serious health effects to both humans and animals; a p-Nitrophenol concentration of 1 ppb changes the taste and odour of water as well as meat and fish quality. In humans, exposure to PNP causes eye and skin burns while its interaction with blood leads to confusion, cyanosis and unconsciousness. It is imperative therefore to find ways for removing PNP from water. Among the available techniques for removing PNP from water, adsorption is more convenient and offers more advantages because of its design, simplicity, and operating flexibility. The present study involved application of peels of raw Afromomum melegueta (RAM) and quaternised Afromomum melegueta (QAM) to remove PNP from water through adsorption. The raw adsorbents were modified with a quaternary ammonium salt to improve their uptake efficiency. The impact of experimental parameters; contact time, pH, sorbent dose, temperature and concentration were investigated. Attenuated FTIR technique was employed to characterize the adsorbent materials. It was established that the quaternary ammonium compound was anchored chemically within the cellulose structure of Afromomum melegueta peels. The behavior of adsorption of PNP was investigated using Langmuir and Freundlich isotherm models. The physical sorption load was 8.70 and 106.38 mg/g for RAM and QAM peels respectively from Langmuir adsorption equation. Uptake of PNP is high at the first 30 mins of contact and at sorbent dosage of 0.01 g and 0.03 g for RAM and QAM respectively. Quantity of PNP removed increases as the initial concentration rises however, adsorption decreases after a concentration exceeding 30 mg/L. The ideal pH and temperature for PNP removal is at pH 3 and 25 ˚C respectively. In conclusion, the findings suggest that Afromomum melegueta peels can be friendly to the environment, cheap biosorbents and efficient which can be applied for the uptake of PNP from drinking water
In vivo Therapeutic Effects and Mechanisms of Hydroxyasiaticoside Combined With Praziquantel in the Treatment of Schistosomiasis Induced Hepatic Fibrosis
Authors: Fang Huilong , Yu Ling , You Da , Peng Nan , Guo Wanbei , Wang Junjie , Zhang Xing
Published: January 2021

Schistosomiasis has been a fatal obstinate disease that threatens global human health, resulting in the granulomatous inflammation and liver fibrosis.

Objective:The aim of this study was to evaluate the therapeutic effects and mechanisms of hydroxyasiaticoside combined with praziquantel in the treatment of schistosomiasis-induced liver fibrosis.

Methods:Mice were randomly distributed into four experimental groups: normal control group, model group, praziquantel group, praziquantel + hydroxyasiaticoside group. Except for the normal control group, they were infected withSchistosomia cercariaethrough the abdominal skin to induce liver fibrosis. In the intervention group, mice were administered with the respective drugs by gavage after 8 weeks of infection. At the end of the treatment, mice were sacrificed to collect blood for the determination of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) serum levels. Moreover, the liver was excised, weighed, and liver indices were calculated. Histopathological examination was performed to assess liver morphology. Besides, the expression of collagen type I and III in liver was determined; the mRNA expression levels of IL-6 and TNF-α in liver tissues were measured using Real-time PCR while ELISA and western blotting were performed on liver tissue homogenate to determine the protein expression of IL-6 and TNF-α.

Results:The combination of praziquantel and hydroxyasiaticoside lowered the pathological scores of schistosomiasis-induced hepatic fibrosis, the liver indice, serum AST and ALT levels, improved liver morphology, downregulated the expression levels of hepatic type I and III collagen, inhibited the mRNA expression levels of pro-inflammatory factors (IL-6 and TNF-α) in the liver of mice relative to the praziquantel alone.

Conclusion:The combination of hydroxyasiaticoside and praziquantel is a potential therapeutic option for schistosomiasis-induced hepatic fibrosis. Notably, this combination noticeably suppresses the protein and mRNA expression levels of pro-inflammatory factors (TNF-α and IL-6) in the liver.
Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy
Authors: Linares Jenniffer , Marín-Jiménez Juan A. , Badia-Ramentol Jordi , Calon Alexandre
Published: January 2021

Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represented in the TME and are continuously interacting with cancer cells. CAFs are regulating key mechanisms during progression to metastasis and response to treatment by enhancing cancer cells survival and aggressiveness. The latest advances in CAFs biology are pointing to CAFs-secreted factors as druggable targets and companion tools for cancer diagnosis and prognosis. Especially, extensive research conducted in the recent years has underscored the potential of several cytokines as actionable biomarkers that are currently evaluated in the clinical setting. In this review, we explore the current understanding of CAFs secretome determinants and functions to discuss their clinical implication in oncology.
Hematopoietic Stem Cell Niche During Homeostasis, Malignancy, and Bone Marrow Transplantation
Authors: Man Yan , Yao Xiangmei , Yang Tonghua , Wang Yajie
Published: January 2021

Self-renewal and multidirectional differentiation of hematopoietic stem cells (HSCs) are strictly regulated by numerous cellular components and cytokines in the bone marrow (BM) microenvironment. Several cell types that regulate HSC niche have been identified, including both non-hematopoietic cells and HSC-derived cells. Specific changes in the niche composition can result in hematological malignancies. Furthermore, processes such as homing, proliferation, and differentiation of HSCs are strongly controlled by the BM niche and have been reported to be related to the success of hematopoietic stem cell transplantation (HSCT). Single-cell sequencing and in vivo imaging are powerful techniques to study BM microenvironment in hematological malignancies and after HSCT. In this review, we discuss how different components of the BM niche, particularly non-hematopoietic and hematopoietic cells, regulate normal hematopoiesis, and changes in the BM niche in leukemia and after HSCT. We believe that this comprehensive review will provide clues for further research on improving HSCT efficiency and exploring potential therapeutic targets for leukemia.
Heat Shock Protein 60, Insights to Its Importance in Histoplasma capsulatum: From Biofilm Formation to Host-Interaction
Authors: Fregonezi Nathália Ferreira , Oliveira Lariane Teodoro , Singulani Junya de Lacorte , Marcos Caroline Maria , dos Santos Claudia Tavares , Taylor Maria Lucia , Mendes-Giannini Maria José Soares , de Oliveira Haroldo Cesar , Fusco-Almeida Ana Marisa
Published: January 2021

Heat shock proteins (Hsps) are among the most widely distributed and evolutionary conserved proteins, acting as essential regulators of diverse constitutive metabolic processes. The Hsp60 of the dimorphic fungalHistoplasma capsulatumis the major surface adhesin to mammalian macrophages and studies of antibody-mediated protection against H. capsulatum have provided insight into the complexity involving Hsp60. However, nothing is known about the role of Hsp60 regarding biofilms, a mechanism of virulence exhibited byH. capsulatum. Considering this, the present study aimed to investigate the influence of the Hsp60 on biofilm features ofH. capsulatum. Also, the non-conventional modelGalleria mellonellawas used to verify the effect of this protein duringin vivointeraction. The use of invertebrate models such asG. mellonella is highly proposed for the evaluation of pathogenesis, immune response, virulence mechanisms, and antimicrobial compounds. For that purpose, we used a monoclonal antibody (7B6) against Hsp60 and characterized the biofilm of twoH. capsulatumstrains by metabolic activity, biomass content, and images from scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). We also evaluated the survival rate ofG. mellonellainfected with both strains under blockage of Hsp60. The results showed that mAb 7B6 was effective to reduce the metabolic activity and biomass of bothH. capsulatumstrains. Furthermore, the biofilms of cells treated with the antibody were thinner as well as presented a lower amount of cells and extracellular polymeric matrix compared to its non-treated controls. The blockage of Hsp60 before fungal infection ofG. mellonellalarvae also resulted in a significant increase of the larvae survival compared to controls. Our results highlight for the first time the importance of the Hsp60 protein to the establishment of theH. capsulatumbiofilms and theG. mellonellalarvae infection. Interestingly, the results with Hsp60 mAb 7B6 in this invertebrate model suggest a pattern of fungus-host interaction different from those previously found in a murine model, which can be due to the different features between insect and mammalian immune cells such as the absence of Fc receptors in hemocytes. However further studies are needed to support this hypothesis
Validation and Comparison of Six Risk Scores for Infection in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention
Authors: Liu Yuanhui , Wang Litao , Chen Wei , Zeng Lihuan , Fan Hualin , Duan Chongyang , Dai Yining , Chen Jiyan , Xue Ling , He Pengcheng , Tan Ning
Published: January 2021

Aims: Very few of the risk scores to predict infection in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI) have been validated, and reports on their differences. We aimed to validate and compare the discriminatory value of different risk scores for infection.

Methods: A total of 2,260 eligible patients with STEMI undergoing PCI from January 2010 to May 2018 were enrolled. Six risk scores were investigated: age, serum creatinine, or glomerular filtration rate, and ejection fraction (ACEF or AGEF) score; Canada Acute Coronary Syndrome (CACS) risk score; CHADS2 score; Global Registry for Acute Coronary Events (GRACE) score; and Mehran score conceived for contrast induced nephropathy. The primary endpoint was infection during hospitalization.

Results: Except CHADS2 score (AUC, 0.682; 95%CI, 0.652–0.712), the other risk scores showed good discrimination for predicting infection. All risk scores but CACS risk score (calibration slope, 0.77; 95%CI, 0.18–1.35) showed best calibration for infection. The risks scores also showed good discrimination for in-hospital major adverse clinical events (MACE) (AUC range, 0.700–0.786), except for CHADS2 score. All six risk scores showed best calibration for in-hospital MACE. Subgroup analysis demonstrated similar results.

Conclusions: The ACEF, AGEF, CACS, GRACE, and Mehran scores showed a good discrimination and calibration for predicting infection and MACE.
Association Between Malocclusion and Academic Performance Among Mongolian Adolescents
Authors: Badrakhkhuu Nomin , Matsuyama Yusuke , Araki Miyu Yoshizawa , Yasuda Yuko Unnai , Ogawa Takuya , Tumurkhuu Tsasan , Ganburged Ganjargal , Bazar Amarsaikhan , Fujiwara Takeo , Moriyama Keiji
Published: January 2021

Objective: Malocclusion has been reported to affect the daily lives of schoolchildren adversely, but little is known regarding the association between malocclusion and academic performance. We aimed to investigate the association between malocclusion and academic performance among adolescents in Mongolia.

Methods: We conducted a cross-sectional study of 767 students aged 7–16 years from two public schools in Ulaanbaatar, Mongolia. Three orthodontists evaluated the need for malocclusion treatment in the participants and determined the type of malocclusion using the Index of Orthodontic Treatment Need and dental casts. The academic scores of study participants in 20 subjects were provided by their schools. Z-scores within subjects were calculated and aggregated into both overall and in six groups of subject categories comprised of mathematics, science, social science, language, arts, and physical education. A multiple linear regression analysis was performed to determine the association between malocclusion, malocclusion type, and academic score adjusted for gender, age, school, and family income.

Results: Of the 767 students, 32.6% had malocclusion, and dental crowding was the most prevalent type (162 cases, 21.1%). Malocclusion was not significantly associated with the z-score of overall academic score [coefficient: 0.04, 95% confidence interval (CI): −0.11 to 0.19]; however, dental crowding was significantly associated with the overall academic score (coefficient: −0.19, 95% CI: −0.35 to −0.03), after adjusting for covariates. Other types of malocclusion were not associated with academic scores. Among the six subject categories, arts (coefficient: −0.20, 95% CI: −0.36 to −0.04) and physical education (coefficient: −0.24, 95% CI: −0.42 to −0.07) were significantly associated with dental crowding.

Conclusions: Schoolchildren in Mongolia with dental crowding may be prone to poor academic performance, particularly in arts and physical education classes. Further randomized controlled trials are needed to determine whether the treatment of crowding boosts academic performance.
Spatial Variations of Tectonic Uplift - Subducting Plate Effects on the Guerrero Forearc, Mexico
Authors: Ramírez-Herrera María Teresa , Gaidzik Krzysztof , Forman Steven L.
Published: January 2021

Uplift is the predominant factor controlling fluvial systems in tectonically deforming regions. Mountains along subduction zones force incision, aggradation, or sinuosity modifications, showing differential uplift and variations in erosion rates, in river incision, and in channel gradient produced by ongoing tectonic deformation. Thus, landscape can provide information on the tectonic activity of a defined region. Here, field studies, analysis of geomorphic indices using a digital elevation model, and dating of river terraces were undertaken to extract the following: (1) determine rates of ongoing tectonic deformation, (2) identify evidence of active faulting, and (3) explain the possible relation of ongoing differential uplift in the topography of the overriding plate with the geometry and roughness effects of subducting slab along the Mexican subduction within the Guerrero sector. Landscape analysis using geomorphic indices suggests segmentation along stream of the studied Tecpan River basin. Rates of tectonic uplift were derived from river incision rates computed with the combination of strath terrace heights and associated dating. Tectonic uplift rates vary from ∼1 ± 0.3 mm/yr up to ∼5 ± 0.6 mm/yr during the Holocene, consistent with inferred high tectonic activity in this zone. These results vary significantly spatially, i.e., increasing upstream. Possible explanations for spatial variations of tectonic uplift rates are most likely related to an effect of the geometry and the rugged seafloor of the oceanic Cocos plate subduction beneath a faulted continental lithosphere.
A High Triglyceride-Glucose Index Is Associated With Contrast-Induced Acute Kidney Injury in Chinese Patients With Type 2 Diabetes Mellitus
Authors: Qin Yuhan , Tang Haixia , Yan Gaoliang , Wang Dong , Qiao Yong , Luo Erfei , Hou Jiantong , Tang Chengchun
Published: January 2021

Background and Objectives

Triglyceride-glucose (TyG) is an emerging vital indicator of insulin resistance and is associated with increased risk of T2DM and cardiovascular events. We aimed to explore the TyG index and contrast-induced acute kidney injury (CI-AKI) in patients with type 2 diabetes who underwent coronary angiology.

Methods

This study enrolled 928 patients with suspected coronary artery disease who underwent coronary angiology or percutaneous coronary intervention in Zhongda hospital. Patient data were divided into quartiles according to the TyG index: group 1: TyG ≤ 8.62; group 2: 8.62<TyG ≤ 9.04; group 3: 9.049.45. CI-AKI was diagnosed according to the KIDIGO criteria. Demographic data, hematological parameters, coronary angiology data, and medications were all recorded. We calculated the TyG index using the following formula: ln [fasting TG (mg/dL)×FPG (mg/dL)/2].

Results

Patients who developed CI-AKI exhibited significantly higher TyG index levels compared to patients who did not develop CI-AKI. The incidence of CI-AKI sharply increased with increasing TyG. Univariate and multivariate analysis identified TyG as an independent risk factor for CI-AKI. The AUC of the ROC curve was as high as 0.728 when the value of TyG was 8.88. The corresponding sensitivity was as high as 94.9%. Adding the variable TyG to the model for predicting CI-AKI risk further increased the predictive value of the model from 80.4% to 82%.

Conclusions

High TyG is closely associated with increased incidence of CI-AKI, demonstrating that TyG is an independent risk factor for CI-AKI. TyG has potentially predictive value for CI-AKI and may play a crucial role in risk stratification in clinical practice.
Modelling of Nicotiana Tabacum L. Oil Biodiesel Production: Comparison of ANN and ANFIS
Authors: Samuel Olusegun D. , Okwu Modestus O. , Tartibu Lagouge K. , Giwa Solomon O. , Sharifpur Mohsen , Jagun Zaid O. O.
Published: January 2021

Among the modern computational techniques, Artificial Neural Network (ANN) and Adaptive Neuro-Fuzzy Inference System (ANFIS) are preferred because of their ability to deal with non-linear modelling and complex stochastic dataset. Nondeterministic models involve some computational complexities while solving real-life problems but would always produce better outcomes. For the first time, this study utilized the ANN and ANFIS models for modelling tobacco seed oil methyl ester (TSOME) production from underutilized tobacco seeds in the tropics. The dataset for the models was obtained from an earlier study which focused on design of the experiment on TSOME production. This study is an an exposition of the influence of transesterification parameters such as reaction duration (T), methanol/oil molar ratio (M:O), and catalyst dosage on the TSOME/biodiesel yield. A multi-layer ANN model with ten hidden layers was trained to simulate the methanolysis process. The ANFIS approach was further implemented to model TSOME production. A comparison of the formulated models was completed by statistical criteria such as coefficient of determination (R2), mean average error (MAE), and average absolute deviation (AAD). The R2 of 0.8979, MAE of 4.34468, and AAD of 6.0529 for the ANN model compared to those of the R2 of 0.9786, MAE of 1.5311, and AAD of 1.9124 for the ANFIS model. The ANFIS model appears to be more reliable than the ANN model in predicting TSOME production in the tropics.
DeCban: Prediction of circRNA-RBP Interaction Sites by Using Double Embeddings and Cross-Branch Attention Networks
Authors: Yuan Liangliang , Yang Yang
Published: January 2021

Circular RNAs (circRNAs), as a rising star in the RNA world, play important roles in various biological processes. Understanding the interactions between circRNAs and RNA binding proteins (RBPs) can help reveal the functions of circRNAs. For the past decade, the emergence of high-throughput experimental data, like CLIP-Seq, has made the computational identification of RNA-protein interactions (RPIs) possible based on machine learning methods. However, as the underlying mechanisms of RPIs have not been fully understood yet and the information sources of circRNAs are limited, the computational tools for predicting circRNA-RBP interactions have been very few. In this study, we propose a deep learning method to identify circRNA-RBP interactions, called DeCban, which is featured by hybrid double embeddings for representing RNA sequences and a cross-branch attention neural network for classification. To capture more information from RNA sequences, the double embeddings include pre-trained embedding vectors for both RNA segments and their converted amino acids. Meanwhile, the cross-branch attention network aims to address the learning of very long sequences by integrating features of different scales and focusing on important information. The experimental results on 37 benchmark datasets show that both double embeddings and the cross-branch attention model contribute to the improvement of performance. DeCban outperforms the mainstream deep learning-based methods on not only prediction accuracy but also computational efficiency. The data sets and source code of this study are freely available at: https://github.com/AaronYll/DECban.
Effects of Unloading on Subsequent Yielding Behavior in 304 Stainless Steel
Authors: Thrun Melissa , Finfrock Christopher , Clarke Amy , Clarke Kester
Published: January 2021

Forming operations are known to be complex, involving many strain states, strain rates, temperatures, strain paths, and friction conditions. Material properties, such as strength and ductility, are large drivers in determining if a material can be formed into a specific part, and for selecting the equipment required for the forming operation. Predicting yielding behavior in situations such as these has been done using yield surfaces to describe material yielding in specific stress states. These models typically use initial mechanical properties, and will require correction if the material has experienced previous straining. Here, we performed interrupted uniaxial tensile testing of a 304 stainless steel to observe the effects of unloading and subsequent reloading on yielding and tensile properties. An increase in yield point developed, in which a higher yield was observed prior to returning to the bulk work hardening behavior, and the magnitude of the yield point varied with unloading conditions and strain imposed. The appearance of a yield point is attributed to strain aging or dislocation trapping at obstacles within the matrix. These results suggest that both strain aging and dislocation trapping mechanisms may be active in the matrix, which may present challenges when forming austenitic stainless and new advanced high strength steels that likely show a similar behavior. These results provide a potential area for refinement in the calculation of yielding criteria that are currently used to predict forming behavior.
Research Progress of Silicon Suboxide-Based Anodes for Lithium-Ion Batteries
Authors: Zhou Xiaozhong , Qi Zhaoyi , Liu Qiang , Tian Jibin , Liu Mingxia , Dong Kaifa , Lei Ziqiang
Published: January 2021

With unique advantages, such as high energy density, long lifespan and environmental friendliness, lithium-ion batteries (LIBs) have been widely used in various portable electronics, and placed great expectations on the application in electric vehicles. To meet the ever-increasing high-energy-density demand of the next-generation LIBs, silicon suboxide SiOx(0 < x < 2) has been considered as one of the most promising anode materials, due to its high mass specific capacity, good cycling performance, proper working potential, low cost, and environmental friendliness. However, there are still several drawbacks before the application of SiOx, such as low intrinsic electronic conductivity and high irreversible capacity in the first cycle, which lead to low electrochemical activity and low initial coulombic efficiency (ICE). To tackle these issues, extensive efforts have been made and remarkable progresses have achieved in recent years. Here, latest developments of SiOx-based anodes are briefly reviewed, especially on the subject of metal/metal oxide doping on SiOx-based electrode materials, and the future application of SiOx anodes in rechargeable LIBs is also prospected.