bluuebunny/crossref_metadata_2025 huggingface dataset:
Zagrożenia dla rynku finansowego związane z praniem pieniędzy a technologie FinTech – identyfikacja zjawiska oraz metody przeciwdziałania
Authors: Charatynowicz Jacek
Published: September 2023

New technologies, including the DeFi (decentralized blockchain technology) market, are a new area of payments, loans and investments. In this article, the author presents the functioning of new technologies, many aspects of which are regulated by national and EU regulations, focusing on the risk analysis of individual and institutional users in the context of the possibility of losing assets, lack of guarantees, volatility of value, or lack of universal acceptance. In addition, due to the technological features of the system architecture, it can be used to legalize the proceeds of crime (money laundering). The article in question is also an attempt to present the areas of tasks of the state in the legislative and operational organizational scope, necessary to be undertaken in the field of counteracting potential threats.
Approaches to correction of immune system disturbances in post-COVID patients
Authors: Dobrynina Maria A. , Zurochka A. V. , Zurochka V. A. , Ryabova L. V. , Sarapultsev A. P.
Published: September 2023

SARS-CoV-2 virus can induce immune system disorders in post-COVID patients, which may persist for an extended period beyond the acute phase of the disease. Therefore, the search for immunocorrection approaches to address the detected disorders is a significant challenge in clinical immunology. This study aimed to investigate the impact of a synthetic peptide derived from the active center of GM-CSF on the immune system of patients with post-COVID immunopathological syndrome. A total of 21 patients who previously suffered with SARS-CoV-2 infection were included in the study. Flow cytometry was used to analyze various immune cell populations, including panleukocyte markers for gated lymphocytes (CD45+ and CD46+), T lymphocytes (CD3+), helper inducers (CD3+, CD4+), cytotoxic T lymphocytes (CD3+, CD8+), TNK cells (CD3+, CD56+), natural killer cells (CD3-, CD56+), B lymphocytes (CD3-, CD19+), activated helper cells (CD3+, CD4+, CD25+), and activated T lymphocytes (CD3+, HLA-DR). Moreover, IgA, IgM, IgG antibodies specific to SARS-CoV-2, phagocytosis and NBT activity of neutrophils, and complement fragments C1q, C3a, and C5a were assessed. The results demonstrated that topical application of the synthetic peptide derived from the active center of GM-CSF (Acegram-spray) upon mucous membranes significantly influenced the functional bactericidal activity of neutrophils (NBT-activity), increased the percentage of T helper cells, and elevated the C3a complement fragment. These findings indicate that the synthetic peptide primarily affects innate immunity factors. However, no significant differences were observed in other immune system parameters. Therefore, the development of therapeutic approaches for post-COVID patients with impaired immune systems may require a search for additional immunomodulators that target T, B, and NK cells. Further research is needed to explore the effects of various immunomodulators on the immune system of post-COVID patients.
Therapeutic effect of a new immunotropic composition tested in the model of periodontitis in experimental animals
Authors: Khlystova K. A. , Chumakov N. S. , Sarkisyan N. G. , Kataeva Natalia N. , Drozdova L. I. , Tuzankina I. A.
Published: September 2023

The article deals with usage of a novel immunotropic drug composition in experimental model of periodontitis. The composition contains silicoorganic glycerogel, exhibits broad spectrum of action upon the etiological pathogen. A good therapeutic effect was revealed by clinical, laboratory and histological criteria. Histology showed absence of osteoclasts, reduced lacunas, higher density and normalization of tissue structures, recovery of microcirculation, angiogenesis and formation of granulation tissues. However, the phosphorus-to-calcium ratio in the group supplied with peroral vitamin D treatment, was characterized by significant decrease in alkaline phosphatase and inorganic phosphorus thus confirming efficiency of complex topical effect of the given composition and vitamin D.
Dynamics of the level of transforming growth factors in blood serum in acute kidney injury in patients after coronary artery bypass grafting
Authors: Markelova E. V. , Fisenko V. G. , Zenina Aleksandra A. , Silaev A. A. , Yermolitskaya M. Z. , Shumatov V. B.
Published: September 2023

Acute kidney injury (AKI) is among most dangerous and common complications after oper-heart cardiosurgical operations. Therefore, a search is carried out for biological markers which could timely detect this condition. The article presents dynamics of TGF-β1, TGF-β2, TGF-β3 in blood serum prior and after a coronary artery bypass (CAB). The study included 120 patients with multivascular affection of coronary blood flow , and 50 conventionally healthy persons of similar age. The 1st group included 50 patients without evidence of AKI, the 2nd group consisted of 70 patients with AKI. Serum TGF-β1, TGF-β2, TGF-β3 was determined by ELISA technique in the main groups before (1) and after surgery (2) as well as on day 2 after operation (3), on day 7 after surgery (4), and once tested in the control group.. The results were expressed in ng/mL or pg/mL, as median values, upper and lower quartiles. Significance levels were determined by the Wilcoxon criterion. We have revealed dynamic changes of TGF-β levels in serum of the patients before and after CAB. Initially, before operation, we have found normal TGF-β1 levels and low TGF-β3 levels in the both main groups. Meanwhile, increased TGF-β2 levels are found only in the subgroup with subsequent AKI development. The dynamics of TGF-β1 showed a decrease just after surgery and 2 days later, being increased over initial level on day 7, and there were no significant differences for the groups with versus without complications. No dynamic differences were revealed for TGF-β2 in the patients of group 1 after surgery. Meanwhile, the group 2 after CAB displayed higher TGF-β2 values compared with controls during the entire follow-up period, neing, however, higher that in the group on the 2nd day following surgery. The TGF-β3 levels were increased just after surgery in both groups followed by subsequent decrease in group 1. In the 2nd group after CAB, the initial deficiency of TGF-β3 was changes in wave-like mode, over 2nd and 3rd period of monitoring. It was increased on day 7, becoming higher than in group1 but did not reach reference values. Further studies in the AKI group after CAB which depend on their severity and outcomes may detect new features of TGF-β system in the patients with this disorder.
Markers of eosinophilic inflammation of airways in patients with fungal sensitilization
Authors: Vasiliev Nikolay Y. , Kozlova Ya. I. , Frolova E. V. , Uchevatkina A. E. , Filippova L. V. , Aak O. V. , Sobolev A. V. , Vasilieva N. V.
Published: September 2023

Immunological characteristics of airway inflammation in asthma patients with sensitization to various fungal allergens are not well understood, and the search for new markers is necessary to establish future targets for targeted therapy. The purpose of our study was to assess the levels of eosinophilic inflammation markers of the respiratory tract in patients with severe asthma and allergic bronchopulmonary aspergillosis, depending on the spectrum of fungal sensitization.
The study included 31 patients with severe asthma with fungal sensitization and 29 patients with allergic bronchopulmonary aspergillosis (ABPA). The levels of total, specific IgE to fungal allergens and periostin in blood serum were determined by enzyme immunoassay. The study of basophil activation was performed by flow cytometry.
The patients with severe asthma and sensitization to Aspergillus spp. and Alternaria spp. had significantly higher levels of eosinophils, periostin, and stimulation index to Alternaria spp. in the basophil activation test when compared with the group of asthma patients with sensitization to Aspergillus spp. only. In patients with ABPA with combined sensitization, we have found significantly higher levels of eosinophils, periostin, and stimulation index to Alternaria spp.
The finding of pronounced eosinophilic type of inflammation in patients with asthma and combined sensitization to thermotolerant and thermolabile fungi may result from aggressive effect of fungal allergens on the barrier functions of bronchial epithelium, which should be taken into account when choosing therapeutic strategy and administration of immunobiological therapy.
Indices of cellular and humoral immunity in a patient with a history of central precocious puberty in anamnesis
Authors: Khisamutdinova Diliara R. , Kozlova Ya. I. , Bashnina E. B. , Frolova E. V. , Uchevatkina A. E. , Filippova L. V. , Vasilyeva N. V.
Published: September 2023

The etiology of precocious puberty includes organic anomalies, genetic mutations, but the primary cause remains unclear in the vast majority of cases. Gonadotropin-releasing hormone (GRH) agonists are used as a treatment of gonadotropin-dependent precocious puberty. Blocking the secretion of gonadotropin-releasing hormone, these drugs stop the premature development of sexual features, prevent premature closure of ossification zones, thereby increasing the child’s expected adult height. The interest in the effects of this group of drugs beyond the hypothalamic-pituitary-gonadal axis has been recently increased. A series of clinical cases have been reported on the development of autoimmune diseases, e.g., autoimmune thyroiditis, Graves disease and type 1 diabetes. The article presents a clinical observation of a patient with central form of premature development who exhibited satisfactory response to treatment with a GRH agonist drug. Further follow-up did not show any reproductive dysfunction. Upon immunological examination, a disturbance was revealed only in the cellular component of immunity. An increased metabolic activity of neutrophils was found, thus, probably, indicating a nonspecific inflammatory process. The levels of immunoglobulins A, M, G matched the reference values. Thus, the therapy with a drug from the group of GRH agonists was effective and safe in terms of influencing the patient’s immune system. The role of hormonal disorders and effects of GRH agonists on the development of immunopathological conditions require further research.
Positive effects of recombinant interferon α2b on the phenotype of CD16+INFα/βR1-CD119+, CD16+INFα/βR1+CD119- neutrophil granulocyte subset in patients with post-COVID syndrome and herpesvirus infections
Authors: Atazhakhova M. G. , Nesterova Irina V. , Chudilova G. A. , Matushkina V. A. , Kovaleva S. V. , Chapurina V. N.
Published: September 2023

Post-COVID syndrome (PCS) is a multisystem inflammatory condition with manifestations of chronic fatigue syndrome (CFS) and cognitive disorders (CD), along with reactivation of chronic herpesvirus infections (HVI). The PCS manifestations require studying the molecular mechanisms associated with the production of IFN and receptor functions of neutrophil granulocytes (NG), which is relevant and promotes the search for immunotherapeutic strategies in patients with PCS. Our objective was to study the in vitro effects of recombinant interferon α2b (recIFNα2b) on the phenotype of CD16+IFNα/βR1-CD119+, CD16+IFNα/ βR1+CD119+ subsets and functional activity of NG in patients with post-COVID syndrome and herpesvirus infections. Materials and methods: 45 patients (24-60 years old) with PCS and HVI (HSV 1, EBV, HHV6, CMV) comprised the study group 1 (SG1). A questionnaire was conducted to assess the severity of PCS symptoms using a point scale. We performed a study of the content and phenotype of NG subsets, i.e., the CD16+IFNα/βR1-CD119+, CD16+IFNα/βR1+CD119-, CD16+IFNα/βR1+CD119+ subpopulation, phagocytic and NADPH oxidase function of NG before and after in vitro incubation with recIFNα2b (50 IU/ µL, for 60 min, at 37 °C) in the study group 1a (SG1a). The comparison group (CG) of 30 volunteers examined during the pre-COVID period. Results: We revealed more pronounced clinical manifestations of CFS and CD in SG1 patients with mixed HVI, than in mono-HVI cases. Increased expression density of all receptors was registered on CD16+IFNα/βR1+CD119-NG and CD16+IFNα/βR1-CD119+ NG, thus suggesting the NG activation with initiation of cytotoxicity or NETosis, a decrease in phagocytic function and intensity of NADPH oxidase activity with depletion of NG reserve capacity in SG1. We have obtained some data on the positive effect of recIFNα2b in vitro (SG1a), e.g., decreased CD16 expression density and enhancement of IFNα/βR1 receptor expression in the CD16+IFNα/βR1+CD119- subset. In the CD16+IFNα/βR1-CD119+ subset, we have found persistence of increased MFI CD16 and MFI CD119 receptors, restoration of defective NG phagocytic function and reduced excessive activity of NADPH oxidases. Conclusion: The positive effects of the recIFNα2b influence on deficient function of NG in PCS patients suggest an oppoptunity of using immunotherapy with a recIFNα2b-based drug, combined with highly active antioxidants for treatment of various PCS manifestations including CFS, CD, HVI, thus, probably, ensuring adequate functioning of antiviral and regulatory mechanisms of the immune system.
Leukocyte cytokine expression is associated with severity of autism in children
Authors: Filippova Yuliya Y. , Alekseeva A. S. , Burmistrova A. L.
Published: September 2023

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with unknown etiology, high clinical heterogeneity and marked aberrations of the immune system. Evidence for an association between immune dysfunction and behavioral traits highlights the need for a study of the immune cell functional activity in order to search for pathogenesis mechanisms and potential targets for therapy at ASD. The purpose: to determine the expression levels of IL-1β, IL-2, IL-4, IL-6, IL-10, IL-18, IFNγ and TNFα in peripheral blood leukocytes of children with mild and severe ASD. The study included 81 children with ASD (77.8% boys) and 45 children with typical neurodevelopment (TDC, 71.1% boys). According to the Childhood Autism Rating Scale, 51 children (63.0%) had mild autistic symptoms (CARS score 32.0±1,5) and 30 children had severe ASD symptoms (CARS score 39.0±3,4). Cytokines expression in leukocytes was determined by quantitative PCR with SYBRGreen. The data were transformed using Box–Cox transformation. The differences between groups were assessed by one-way ANOVA and Dunn’s test for multiple comparisons. In leukocytes of children with ASD, regardless of the severity, the expression of IL-1β, IL-18 and IL-2, was significantly reduced compared to TDC. Moreover, in children with mild ASD, low expression of TNFα, compared with TDC was found. In children with severe ASD, the expression of the main cytokine of Th1 – IFNγ, was significantly increased, without an increased expression of an important cytokine of Treg – IL-10. Activation of the Th1 adaptive immune response without compensation by cytokines of Treg, the number of which is reduced in ASD, can lead to increased inflammation, even in the central nervous system, and correlates with the severity of ASD clinical symptoms. Despite extensive immunological evidence suggesting immune system dysregulation, further research is required to clarify the relationship between immune system cell function and ASD pathology.
Efficiency of combined postoperative treatment including an immunomodulatory Hexapeptide in children with acute destructive pneumonia
Authors: Chapurina V. N. , Nesterova Irina V. , Chudilova G. A. , Kovaleva S. V. , Lyagusha D. E. , Teterin Yu. V. , Barova N. K. , Tarakanov V. A.
Published: September 2023

Acute destructive pneumonia (ADP) is a severe purulent and septic infectious disorder of childhood, characterized by a high level of morbidity and associated with imbalance of the immune system (IS). Hence, there is an obvious need to study the immunopathogenesis of this disease in order to develop new therapeutic strategy aimed at eliminating the pathogen, detoxifying the body, relieving respiratory failure and correcting functional immune deficiency. Our aim was to perform a clinical and immunological study in order to evaluate efficiency of immunomodulatory therapy using a medical drug with hexapeptide as an active substance. This drug was included into the complex postoperative treatment of children with acute destructive pneumonia. Clinical and immunological examination of 15 children 2-5 years old with ADP was performed before (study group 1 – SG1) and after (study group 1a – SG1a) combined postsurgical treatment including immunomodulatory therapy with a Hexapeptide-based pharmaceutical (HP, Arginyl-alpha-Aspartyl-Lysyl-Valyl-Tyrosyl-Arginine). Comparison group (CG) included twenty healthy children. The contents of T and B lymphocytes, natural killer cells (NK) were measured by means of flow cytometry (CYTOMICS FC 500, USA). Serum levels of IgA, IgM, IgG (ELISA), phagocytic and microbicidal activity of neutrophil granulocytes (NG) were also evaluated. Prior to the treatment in SG1 patients, a decreased number of CD3+CD19-T lymphocytes, CD3+CD8+ TCTL lymphocytes was revealed along with significant decrease in the contents of CD3-CD16+CD56+ NK (p1-3 0.05). It was found that in children with ADP, the IgG level did not differ from indices of control group, with a decrease of IgM (p1, 2 0.05), and increased level of IgA (p 0.05). We have also found a deficiency of NG effector functions, i.e., insufficiency of active phagocytic NG with impaired capture and killing of bacterial antigen. Assays of NADPH-oxidase activity showed lacking response to both inflammation and additional induction by S. aureus. After complex treatment including immunomodulatory therapy in the SG1a group, we revealed a recovery in CD3+CD19-T lymphocyte contents, CD3+CD8+TCTL lymphocytes, CD3-CD16+CD56+ NK (p1-3 0.05). The trends towards normalization of IgA, IgM, improved NG effector functions (killing ability) were revealed due to activation of NADPH-oxidases. The restoration of immunological parameters in ADP was associated with earlier recovery from the purulent-destructive process in lungs, absence of postoperative complications including the prevention of septic process. The clinical and immunological effects of the immunomodulatory therapy program with HP-based pharmaceutical preparations suggest its potential usage during postoperative period in immunocompromised children with ADP.
Single nucleotide polymorphism of osteoprotegerin as a possible biomarker of rheumatoid arthritis in Bashkir population of Chelyabinsk region
Authors: Chumacheva Yu. V. , Stashkevich Darya S. , Devald I. V. , Suslova T. A.
Published: September 2023

Rheumatoid arthritis (RA) is a multifactorial autoimmune rheumatic disease of unknown etiology characterized by chronic erosive arthritis. The protein osteoprotegerin (OPG) is a member of bone tissue homeostasis (RANK/RANKL/OPG) which is responsible for the regulation of osteoclast differentiation and osteolysis. The altered binding of RANKL and OPG is one of the causes of many diseases with increased production of pro-inflammatory cytokines, including rheumatoid arthritis. Polymorphic variants of the genes that control protective reactions could affect the level of production for encoded proteins and, thus, changing the course of immune response in RA. G1181C SNP in osteoprotegerin gene leads to disruption of its transcriptional activity and conformation of the protein itself, which can lead to an imbalance of pro- and anti-inflammatory cytokines. We analyzed the relationship between the TNFRSF11B gene polymorphism at the 1181 G C position and the risk of developing RA in the Bashkir population. The analysis was based on a molecular genetic study of single nucleotide polymorphism in groups of patients with rheumatoid arthritis and conditionally healthy individuals of the Bashkir population of the Chelyabinsk Region. Statistical evaluation was carried out using standard criteria generally accepted in immunogenetics. The 1181*GC polymorphism of the osteoprotegerin gene is characterized by interpopulation differences, which confirms the importance of using an ethnically identical comparison group to assess the association with a predisposition to multifactorial pathology. We showed that the carriage of genotype 1181 G/C was increased in the group of Bashkirs with rheumatoid arthritis. This genotype could be considered a biomarker of susceptibility to RA. No differences in the SNP allelic frequencies and genotypes were found among women with RA. Our research is a part of comprehensive assessment of the interaction of cytokines and their receptors from the TNFαsuperfamily as an immunogenetic component of RA genesis.
Role of NLRP3 in the immunopathogenesis of neurodegenerative eye diseases
Authors: Balatskaya N. V. , Gavrilova T. V. , Kinkulkina Aliya R. , Avagyan A. S. , Svitich O. A.
Published: September 2023

Neurodegenerative eye pathology is one of the leading causes of visual impairment and blindness worldwide. Primary open-angle glaucoma (POAG) belongs to the group of neurodegenerative ophthalmic diseases and is characterized by a permanent or periodic increase in intraocular pressure, followed by development of typical visual field defects, decreased visual acuity and optic nerve atrophy. Recent studies show that local inflammation, triggered by the innate immune system is the first line of defense against the pathogens and tissue destruction products, playing an important role in the POAG pathogenesis. The aim was to study the neurodegenerative ophthalmic disorder in a rabbit model, and to compare the data on distribution of alleles and genotypes of the polymorphic marker rs7525979 of NLRP3 gene in the patients with POAG. At the first stage, we studied the complex tissue samples of the retina/retinal pigment epithelium (TCS/RPE) isolated from the eyes of 14 experimental animals and 7 intact rabbits without eye damage. Neurodegenerative pathology of the eye in rabbits was carried out in the Experimental Center at the Helmholtz National Medical Research Center by a single subretinal injection of 0.01 ml of 0.9% sodium chloride solution. NLRP3 gene expression levels in TCS/RPE samples were evaluated by real-time polymerase chain reaction (PCR-RV). At the second stage, peripheral blood samples were examined in patients who were diagnosed with POAG of various stages, as well as without glaucoma. DNA was isolated from blood samples, which was subsequently analyzed for the polymorphic markers study using PCR-RT technique. According to the results of the study, we noted an increased expression of the NLRP3 gene in the TCS/RPE samples from experimental animals with simulated retinal degeneration. Moreover, an association of alleles and genotypes of the NLRP3 gene was revealed in patients with POAG. The data obtained may be indicative for involvement of NLRP3 inflammasome components in development of neurodegenerative retinal lesions in POAG.
Immune system dysfunction in purulent inflammatory diseases of the maxillofacial area in pediatric patients
Authors: Mitropanova Marina N. , Ponomarenko T. A. , Chudilova G. A. , Teterin Yu. V. , Chapurina V. N.
Published: September 2023

The issues of treatment of purulent inflammatory diseases of the maxillofacial region (PMMA) are quite urgent, due to increasing number of such patients. Their clinical course is getting worse, and the efficiency of antibiotic therapy is decreasing. Clinical outcomes of purulent maxillofacial pathology in children are complicated by potential severe local deformities at the growth areas of the jaw bones which are difficult to eliminate. The number of cases of prolonged and chronic inflammatory processes, development of local and general complications is increased. The reason for these complications may be an impaired susceptibility to infectious agents, which is determined by the state of the immune system. Therefore, our aim was to reveal some features of immune functions in children with purulent-inflammatory diseases of maxillofacial area.
The study included a group of pediatric patients 8-17 years old with maxillofacial inflammatory diseases of the maxilla (the study group), and 13 conditionally healthy children (the comparison group). The contents of T cells (CD3+CD19-, CD3+CD4+, CD3+CD8+, CD3+CD4+/CD3+CD8+), and В cells (CD3-CD19+), NK (CD3-CD16+CD56+) was determined using Cytomics FC-500 (Beckman Coulter, USA);concentrations of serum IgA, IgM, IgG were determined by ELISA technique (Vector-Best, Russia). Phagocytic activity of neutrophilic granulocytes (NG) was evaluated as percentage of actively phagocytic NGs, capturing processes were assessed by appropriate phagocytic indices, and the digestive activity was evaluated against S. aureus (strain 209).
Combined defects of immune response in children with maxillofacial hypertension were established: decrease of T lymphocytes contents along with decrease of T helpers and CTL ratio along with unchanged content of NK cells and B lymphocytes. Increase of IgA and IgG levels was also found. Defects of phagocytosis were revealed, primarily connected with the processes of completed phagocytosis and increased content of actively phagocytizing NG.
Treatment of children suffering with purulent inflammatory diseases of maxillofacial region is still an urgent problem in dentistry. The revealed dysfunction of immune response to pathogens in the purulent maxillofacial disorders may explain a prolonged clinical course of inflammatory processes, thus determining a need for usage of immunotropic therapy in complex treatment schedules including operative aid as well as conventional drug and physiotherapeutic treatment aiming for increase of rehabilitation efficiency and prevention of postoperative complications in these patients.
Clinical and immunological efficacy of intranasal interferon in the post-vaccination period in patients vaccinated against SARS-CoV-2 coronavirus
Authors: Savin T. V. , Tyurina T. O. , Milichkina A. M. , Drozd I. V. , Kuznetsova Raisa N. , Simbirtsev A. S. , Totolyan Areg A.
Published: September 2023

The COVID-19 pandemic, caused by SARS-CoV-2, remains one of the actual medico-social issues of today's world. Novel coronavirus infection officially listed in dangerous infections. When an ingress of coronavirus infection in the background of intensive production of inflammatory inducers comes with decreased levels of type I interferon that cause loss of protective abilities of the body against the background of the destruction of its own tissues. Herd immunity development via vaccination increases the proportion of people with protective immunity against SARS-CoV-2 is an important factor in stopping the spread of the infection. However, during the first days after vaccination, patients remain susceptible to possible infection. A promising prophylactic agent is interferon-containing drugs widely used in Russia and CIS countries for the prevention and treatment of viral infectious diseases, in particular SARS and influenza. Our study showed that intranasal recombinant IFNα-2b has clinical and immunological efficacy after two courses of the drug (within 5 days after V1 and after V2 vaccination with the EpiVacCorona vaccine).
A PRODUÇÃO DE CONHECIMENTO SOBRE A ÉTICA E A ÉTICA PROFISSIONAL NA PÓS-GRADUAÇÃO EM SERVIÇO SOCIAL NA CONTEMPORANEIDADE
Authors: Gonçalves de Lima Sáskya , Barros da Nóbrega Mônica
Published: September 2023

No presente artigo, buscamos discutir, brevemente, a partir de projeto de pesquisa apresentado ao Programa de Pós-Graduação em Serviço Social da Universidade Estadual da Paraíba (UEPB), a produção de conhecimento na atualidade, no que toca à ética e à ética profissional nos programas de pós-graduação em Serviço Social do Brasil. Para isso, primeiro trilhamos um breve caminho histórico pela produção do conhecimento em Serviço Social, para contextualizar e demonstrar a importância dessa produção para a profissão, ainda mais que a fez se configurar como área do conhecimento. Em seguida, adentramos no debate da ética e da ética profissional, ressaltando a relevância do tema tanto para a formação quanto para o fazer profissional, encerrando o trabalho com as nossas considerações finais e referências utilizadas. Pretendemos fomentar a discussão acerca do tema exposto, pois acreditamos ser fundamental, principalmente no atual contexto em que vivenciamos a agudização do conservadorismo societal, com fortes repercussões para a profissão.
REFORMA TRABALHISTA E A (RE)PRODUÇÃO RENITENTE DAS DESIGUALDADES NO BRASIL
Authors: Ghiraldelli Reginaldo , Reis Silva Isabella , Araújo da Costa Karollyne , Soares Carvalho Lucas Tenório , Pereira Carvalho Thais
Published: September 2023

Este artigo apresenta reflexões sobre a Reforma Trabalhista, aprovada em 2017, e suas implicações para o desmonte do sistema de proteção social brasileiro. Também considera o cenário de emergência da pandemia da Covid-19 e suas consequências para as relações sociais e laborais. A partir de análise bibliográfica, documental e de indicadores sociais, observa-se que após a aprovação da Reforma Trabalhista, propagada pelos ideólogos neoliberais como solução para a crise capitalista, ocorre um exponencial aumento do desemprego, de subempregos e de contratações caracterizadas por vínculos instáveis, frágeis e precários de trabalho. Essa realidade revela um processo de desconstrução dos direitos sociais de cidadania e a persistência das desigualdades no Brasil.
Порівнювальний аналіз двох підходів визначення об’єму і маси деталей складної конфігурації
Authors: Konoplev A.V. , Ducret L.G. , Zelinsky V.F. , Bershak S.V.
Published: September 2023

У статті проведено порівняльний аналіз двох підходів до визначення об’єму і маси деталей машин складної конфігурації на етапі проєктування. На основі проведеного аналізу показано, що більш точний результат може бути досягнутий при автоматизованому проєктуванні в універсальній графічній системі AutoCAD, з використанням методу тривимірного геометричного моделювання, який містить прийоми і методи побудови об’ємних візуальнообразних моделей об’єктів у віртуальному тривимірному просторі, забезпечує зв’язок графічних об’єктів із зовнішніми базами даних і являє собою потужний пакет для автоматизації розробки та виконання проєктноонструкторських та інших графічних документів. Технології тривимірного геометричного моделювання значно розширюють сферу застосування геометричних моделей у проєктно-конструкторській діяльності і дозволяють використовувати їх не тільки у конструкторському проєктуванні, а і здійснювати інженерний аналіз та отримувати дані, необхідні для виробничого процесу.
Вибір маневра повернення судна На програмну траекторію руху без координації з ціллю
Authors: Kalinichenko T.
Published: September 2023

У статті розглядається одна з багатьох проблем попередження зіткнень суден як однією з найактуальніших у забезпеченні безпеки судноводіння. В процесі комп'ютерного імітаційного моделювання процесу розходження суден, що знаходяться на невеликих відстанях небезпека зіткнення може виник нути на етапі повернення суден на їх програмні траєкторії руху. У статті отримано умову безпечного виходу судна на програмну трак торію руху для випадку, коли не виконується координація з ціллю. Наведено вираз відносної кутової швидкості, що виникає під час повороту суден, а також представлено графічну залежність відносної кутової швидкості від часу.
Особливості моделювання процесів Зміни технічного стану з складовою випадковості
Authors: Golovan A.I.
Published: September 2023

В межах сучасних умов експлуатації вантажних суден, особливу актуальність набуває проблема підтримки та оптимізації технічного стану суднових технічних засобів. При цьому, одним з важливих аспектів є врахування випадкових факторів, які можуть впливати на ефективність та надійність суден. Це стає особливо актуальним, коли мова йде про великі вантажні судна, що роблять довгі рейси, де вірогідність випадкових пошкоджень чи відмов є високою. Представлена стаття присвячена дослідженню методів моделювання процесів зміни технічного стану суднових технічних засобів вантажних суден. Важливість теми обумовлена необхідністю прогнозування та планування технічного обслуговування суден, що включає різні складові, зокрема двигуни, корпус, рушій, навігаційне обладнання, енергетичне обладнання, та інше. Розглянуто аналітичні та статистичні методології моделювання, а також враховано випадкові експлуатаційні фактори, що діють в інтервалі між технічним обслуговуванням суднових технічних засобів. У статті визначено, що задачі моделювання процесів зміни технічного стану включають аналіз швидкості зміни технічного стану, яка відображає динаміку змін технічного стану засобів вантажного судна і є важливим індикатором для планування та проведення технічного обслуговування. У статті проведено порівняльний аналіз аналітичних та статистичних методологій моделювання, що використовуються для деталізації закономірностей варіативності технічного стану, формування моделей регулярностей еволюції та акумуляції пошкоджень. Досліджено вплив випадкових експлуатаційних факторів на процеси зміни технічного стану між технічним обслуговуванням суднових технічних засобів. Виявлено, що випадкові експлуатаційні фактори можуть охоплювати різні морські умови, навантаження, погодні умови та інші фактори, що впливають на стан судна та його технічних засобів між плановими технічними обслуговуваннями. Результати дослідження можуть бути використані для оптимізації графіка технічного обслуговування, заснованого на реальному стані суднових технічних засобів.
Пристрій для гасіння енергії вітрових хвиль
Authors: Panova I. , Rogachko S.
Published: September 2023

Морські порти України потребують суттєвої реконструкції у зв’язку зі зростанням обсягів перевезень наливних вантажів та зрідженого газу сучасними великотоннажними спеціалізованими суднами, які можна здійснювати, використовуючи рейдові причали. Їхнє будівництво не вимагає відносно великих фінансових витрат і може бути реалізовано у більш короткі терміни. Не менш важливим народногосподарським завданням у нашій країні є розробка перспективних родовищ вуглеводнів, що розвідані на шельфі Чорного моря. Облаштування та експлуатація таких родовищ на помірних глибинах води також вимагає будівництва рейдових причалів та морських нафтогазопромислоих гідротехнічних споруд (МНГС). Проектування гідротехнічних споруд для експлуатації у відкритому морі неможливе без вдосконалення конструкцій їх надводних частин та нормативної бази. У даній статті наведено пристрій для зниження хвильових навантажень на морські гідротехнічні споруди, розроблений на основі аналізу результатів лабораторних експериментальних досліджень, проведених авторами.
Erken Cumhuriyet Dönemi Demiryolu İşlerinin Nafia Mecmuası Üzerinden İncelenmesi
Authors: POLAT ALPAN Mine , AYDIN SANCAROĞLU Aysun
Published: September 2023

Bu çalışmada, Erken Cumhuriyet Dönemi’nde yapılan tüm demiryolu çalışmaları 1934-1949 yılları arasında yayınlanan Nafia İşleri Mecmuası isimli dergi üzerinden incelenmiştir. Dönemin hükümeti tarafından aylık olarak çıkarılan dergide, demiryolu ile ilgili yapılan tüm işlerin detayları bildirilmekte ve halkın bu sayede ülkede yapılan işlerden ve bunların detaylarından haberdar olması sağlanmaktaydı. Bu çalışma, Cumhuriyet’in kurulmasının hemen ardından izlenen demiryolu politikasının detaylarını görmek, adımlarını izlemek, ülkede ne gibi faydaların sağlandığını tespit etmek ve bu politikanın hedefine ulaşması noktasındaki başarısını inceleyebilmek amacıyla yapılmıştır. Nafia İşleri Mecmuasının incelemeleri kantitatif yöntemle yapılmış, dergi okumaları yapılıp demiryolu ile ilgili başlıklar ayıklanmış, yıllık olarak içerikler belirlenmiş, tablolaştırılmış ve yorumlanmıştır. Çalışmada sonuç olarak, Nafia İşleri Mecmuası aracılığıyla, Erken Cumhuriyet Dönemi’nde yapılmış demiryolu işlerinin karar, uygulama ve işletme süreçlerindeki tüm detayları belirlenmiştir. Bu teknik detayların yanı sıra devletin benimsediği demiryolu politikası ve izlenen politikanın başarısı da gözlemlenmiştir.
The Influence of Budget Participation, Information Asymmetry, and Budget Emphasis on Budgetary Slack in Aceh Government
Authors:   Faculty of Economics and Business, Syiah Kuala University, Banda Aceh, Fatimah Fatimah , Abdullah Syukriy ,   Faculty of Economics and Business, Syiah Kuala University, Banda Aceh, Meutia Rita ,   Faculty of Economics and Business, Syiah Kuala University, Banda Aceh
Published: September 2023

This study aims to examine the effect of budgetary participation, information asymmetry, and budget emphasis on budgetary slack in the SKPA Aceh Government. The population of this research is all State Civil Servants (ASN) in SKPA Aceh Government. The research sample used was 129 people selected by purposive sampling method, consisting of Heads of SKPA, Secretaries, and Heads of Planning and Reporting Subdivision in 43 SKPA. This research is a quantitative research, the data used is in the form of primary data obtained from distributing questionnaires to research respondents. The data analysis technique uses multiple linear regression analysis with the help of the IBM SPSS 26 program. The regression results for the partial test show that budget participation, information asymmetry, and budget emphasis have a positive and significant effect on budgetary slack in the Aceh Government SKPA.
Legal Consequences of not Attaching Fingerprints to Minuta to Notary Deed
Authors:   Master of Notary, University of Lambung Mangkurat, Maliha Zata Yumni , Effendy Mohammad ,   Faculty of Law, University of Lambung Mangkurat, Gozali Djoni Sumardi ,   Faculty of Law, University of Lambung Mangkurat
Published: September 2023

An authentic deed drawn up by a Notary as a general or public official becomes very important and is needed by parties as appearers. One of the Notary's obligations regulated in Article 16 (1) c explains that the Notary is obliged to attach letters and documents as well as the fingerprints of the person appearing on the Minuta Deed. However, what becomes a legal issue in this scientific research article is what if the appearer does not want to affix or attach his fingerprints to the minutes of the deed because Article 16 (1) c still contains a vague norm. So that the purpose of this scientific research article is to analyze whether the Notary is personally responsible for not including fingerprints at the request of the appearer and whether not including the fingerprints of the appearer in the minutes results in the position of the notary deed as an authentic deed. The method in this scientific research article uses the method of normative legal scientific research articles. The results of the analysis of this scientific research article show that first, not attaching or affixing the appearers fingerprints to a minutes of notary deed based on the request of the appearer itself remains the responsibility of the notary. Second, not affixing the fingerprints of the appearer on the minutes of the Notary Deed theoretically does not have any effect on the validity, but based on the evidentiary side this can be a consideration for the judge to then abort the minutes of the Notary deed under the hand. So, it is necessary to revise the provisions related to fingerprints in the Notary Law with the aim of clarifying and it becomes necessary to explain in more detail and detail the mechanism of affixing or attaching fingerprints to the minutes of notary deed.
Legal Consequences of Making a Notary's Cover Note in the Implementation of Notary's Duties
Authors: Lubis Ikhsan , Murwadji Tarsisius , Sunarmi Sunarmi , Sukarja Detania
Published: September 2023

Introduction: One of the legal goods provided by a notary is a cover note, which is a statement in the management of a deed or a notarial document stating that the deed is in progress and can be finished within the time set by the cover note.Purposes of the Research:  A notary certificate is referred to as a cover note, as a substitute for the process of obtaining a certificate from a notary public, land title guarantees can be replaced temporarily depending on needs and developments. Notaries can make issue cover notes, which have legal consequences and make legal norms null and void. The legal basis for making and issuing cover notes is not yet known. This paper discusses two matters: What legal authority does a notary have to issue a cover note? What are the legal consequences of publishing a cover note by a notary? Methods of the Research: This is typical of legal writings that take a legal approach and examine legal concepts. In socio legal research, research begins with a hypothesis. After formulating the hypotheses, the hypotheses are tested. Data collection techniques in socio legal research are carried out through interviews, observation, questionnaires and document analysis.Results of the Research: However, notaries are allowed to issue and make cover notes because it is a form of agreement. This paper concludes that there is no legal basis for regulating cover notes. If the duties and authorities do not comply with the contents of the cover note, the law will result in a violation of Article 1366 of the Criminal Code.
Development of Emotional Intelligence and Leadership aspects applied in Health Professionals. A Scoping Review
Authors: Koutsioumpa Eftichia
Published: September 2023

The healthcare industry, known for its demanding work environment and extensive interpersonal engagements, requires individuals to possess technical proficiency, deep emotional intelligence (EI), and practical leadership abilities. This paper examines the significance and progression of emotional intelligence concerning leadership qualities, specifically focusing on health professionals. Recent research findings indicate that a growing body of data supports that health professionals with more significant emotional intelligence (EI) demonstrate increased patient care, more vital collaboration within teams, and more effective decision-making. The patient-centric approach in the medical industry is closely associated with key elements of Emotional Intelligence (EI), including empathy and self-awareness. These components are essential in fostering effective patient care and should be prioritized in healthcare professionals' skill development. In addition, healthcare executives with well-developed emotional intelligence (EI) can manage and traverse the complexities of team interactions effectively, promoting optimal performance even in high-pressure situations. Contemporary instructional approaches, such as simulation training, reflective practice, and mentorship programs, exhibit the potential to foster these characteristics. In conclusion, the cultivation of emotional intelligence in conjunction with leadership abilities among healthcare professionals enhances the standard of patient care and reinforces the resilience and effectiveness of healthcare teams. Incorporating emotional intelligence (EI) and leadership development into medical training and ongoing professional education is increasingly recognized as a crucial approach for advancing healthcare in the future.
The Impact of Green Legacy on Climate Change in Ethiopia
Authors: Lambert Edward , Deyganto Kanbiro Orkaido
Published: September 2023

A green legacy initiative plays a crucial role in promoting a healthy environment in Ethiopia by restoring ecosystems, mitigating climate change, and fostering environmental awareness and stewardship. Through its tree planting efforts, the initiative aims to create a sustainable and resilient environment that benefits both nature and the people of Ethiopia. The research gap lies in the need for comprehensive studies that assess the impact of the green legacy initiative on promoting a healthy environment in Ethiopia. This includes evaluating its impact on biodiversity conservation, soil conservation, and the social and health outcomes of local communities. The mixed–method research was employed by researchers. The regression result was evidenced that tree planting, growing trees for carbon sequestration, biodiversity conservation, soil conservation, community engagement, and climate education have positive statistically significant effect on healthy environment in Ethiopia. Based on the research findings, the researchers were forwarded the recommendations for policymakers and government of Ethiopia to take into consideration the six parameters of green legacy in implementing green legacy incentives in Ethiopia. Addressing these parameters of green legacy will provide a more holistic understanding of the initiative’s effectiveness and contribute to evidence-based decision-making for sustainable environmental management in Ethiopia.
 
Received: 18 July 2023 | Revised: 11 September 2023 | Accepted: 13 September 2023
 
Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.
 
Data Availability Statement
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
Kamu Diplomasisinde Küresel İşbirliğinin İmkan ve Sınırları: Küresel Kamu Diplomasisi Ağı’nın Analizi
Authors: GÜNEK Abdulsamet
Published: September 2023

ÖZ

Kamu diplomasisi faaliyetleri ülke imajlarının yükseltilmesi açısından rekabetçi bir yapıya dayanmakta ve her ülkenin ülke çıkarlarının başka ülkeler nezdinde elde edilmesine yönelik yürüttüğü faaliyetleri içermektedir. Küresel düzenin bir takım teknik ve politik nedenelere bağlı olarak dönüşümü, sorun ve çözümlerin küreselleşmesi kamu diplomasisini kaçınılmaz olarak küresel işbirliğine yöneltmektedir. Dünyanın farklı bölgelerinden 26 ülkenin kültür diplomasisi kurumlarının oluşturduğu Küresel Kamu Diplomasisi Ağı (GPD Net) kültür diplomasi faaliyetlerinde çoklu işbirliğinin iyi bir örneğidir. Bu çalışma özelde kamu diplomasisi genelde ise kültür diplomasi faaliyetlerinde uluslararası ve kültürlerarası işbirliğinin imkân ve sınırlarını Küresel Kamu Diplomasisi Ağı (GPDNet) üzerinden analiz etmektedir. Bu amaçla GPDNet’in kurumsal yapısı; eylemler, kapasite geliştirme, kültürel ağ ve bilgi değişimi bağlamında değerlendirilmiştir. Küresel işbirliği söylemini analiz etmek amacıyla ise kurumun dijital içerikleri kategorize edilerek içerik analizine tabi tutulmuştur

Anahtar Kelimeler: kamu diplomasisi, kültür diplomasisi, GPDNet, Kamu Diplomasisinde Küresel İşbirliği, Kamu Diplomasisinde Rekabet
Cartilha digital: o direcionamento dos resíduos eletroeletrônicos através de ações educativas na educação básica
Authors: Santos Janaina Luiza Simões dos , Silva Rafaela Alves Pereira da , Severo Gomes Bruno
Published: September 2023

O direcionamento correto dos resíduos eletroeletrônicos vai muito além de medidas voltadas a conservação ambiental, trata-se de modelos de gestão que vise  garantir ações coletivas gerando a conscientização socioambiental quando aplicada corretamente  perparssando os muros escolares . Dessa maneira, o presente trabalho tem como objetivo promover  educação ambiental através  do uso das cartilhas digitais , de modo que colabore  para o compartilhamento do tema  no processo de ensino e aprendizado na educação básica. O conteúdo da cartilha foi pensada para ser utilizada de forma interdisciplinar pelos docentes em diversas áreas de conhecimento. A pesquisa foi realizada  em uma escola estadual em Aldeia, localizada no municipio de Camaragibe –PE. Sendo realizada uma pesquisa  qualitativa efetiva obtendo assim dados que juntamente com uma pesquisa bibliográfica contribuíram para a elaboração do produto educacional.  Após submeter o produto educacional desenvolvido à análise de educadores, foi verificado que este pode contribuir para que os educandos compreendam a importância do descarte correto dos resíduos eletroeletrônicos a construção permanente da conscientização, sensibilização norteando a prática dessas ações socioambientais através da Educação.