bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of Antibodies against Tick-Borne Encephalitis Virus in Zoo Animals Using Non-Invasive Blood Sampling with Medicinal Leeches (Hirudo medicinalis)
Authors: Kvapil Pavel , Kastelic Marjan , Jež Nuša , Sedlák Kamil , Kašpárková Nikola , Jelovšek Mateja , Avšič-Županc Tatjana , Bártová Eva , Račnik Jožko
Published: July 2021

Reports on non-invasive blood sampling are limited, and there are only a few studies on using kissing bugs (Reduviidae) and medicinal leeches (Hirudo medicinalis) for hematology and biochemistry testing in various zoo animal species. The aim of this study was to evaluate the usefulness of non-invasive blood sampling with medicinal leeches for arbovirus epidemiological investigations in various animal species from one zoo collection. Medicinal leeches were manually applied on 35 animals of 11 species. Control blood samples were obtained by venipuncture of the jugular vein. Antibodies to tick-borne encephalitic virus (TBEV) were detected by using the immunoenzymatic method or an immunofluorescent assay (IFAT), depending on the animal species. One of the 35 animals (2.9%) was seropositive (Ovis aries), whereas the rest of the samples were seronegative in both methods of sampling (non-invasive by leeches vs. invasive by venipuncture). Blood sampling using medicinal leeches showed promising results. It is likely a good alternative to other more complex and invasive methods, and it can provide significant advancement in blood sampling for preventive medicine and epidemiological studies in zoo animals.
The use of reflexology techniques for the treatment of psychoemotional and cognitive disorders in persons who have suffered from COVID-19
Authors: Izvekov Alexander Alexandrovich , Khritinin Dmitrii Fedorovich , Tyan Viktoriia Nikolaevna , Kapto Oksana Vladimirovna , Karakozov Aram Grigorevich , Katenko Sergey Vladimirovich , Eremin Mikhail Nikolaevich , Karakozova Marina Grigorevna , Levchenko Olga Borisovna , Molodova Alevtina Igorevna
Published: July 2021

The article describes the use of reflexotherapy techniques in the complex treatment of psychoemotional and cognitive disorders in people who have suffered from COVID-19.
Postoperative cerebral dysfunction in carotid endarterectomy — a modern prevention strategy
Authors: Ivolgin A. F. , Litvinenko I. V. , Tsygan N. V. , Samushiya M. A. , Ragimova A. A.
Published: July 2021

Based on 48 foreign and domestic publications, a systematic review on the prevention of postoperative cerebral dysfunction (POCD) that develops after reconstructive operations on the carotid arteries was carried out. Main conclusions. Reconstructive operations on the carotid arteries, which are the leading direction in the prevention of ischemic strokes in stenosing atherosclerotic lesions of the brachiocephalic arteries and, primarily, of the internal carotid artery, can cause the development of postoperative cerebral dysfunction. The current strategy for reducing the risks of cognitive impairment after surgery is not fully developed and requires further research.

English version of the article on pp. 165-172 is available at URL: https://panor.ru/articles/postoperative-cognitive-dysfunction-after-carotid-endarterectomy-current-preventive-strategy/63915.html
Taxanes use and neurotoxicity in cancer patients
Authors: Tkachenko E. V. , Andreev V. V. , Yatsenko A. V. , Zheltukhin A. A. , Gorbunova K. V. , Kondratiev S. V. , Klyuge V. A. , Brish N. A. , Alekseeva Yu. V. , Sluzhev M. I. , Kasparov B. S. , Bondarev N. E. , Mimonov E. A. , Semiglazov V. V. , Semiglazova T. Yu. , Belyaev A. M.
Published: July 2021

The review presents the data on the specifics of mechanism of action, classification, and clinical manifestations of neurotoxicity effect. The most significant features of specific side effects when using taxanes in different treatment regimens, including cumulative doses, are considered. The proven methods of treatment and prevention of neuropathy caused by anticancer drugs are discussed.
Spinal cord stimulation in the treatment of chronic peripheral neuropathic pain
Authors: Nikitin Andrey Sergeevich , Nanaev Roman Musaevich , Nekhoroshikh Aleksandra Egorovna , Kudryavtseva Ekaterina Vladimirovna
Published: July 2021

A review of the modern literature on the issues of spinal cord stimulation in peripheral chronic neuropathic pain is presented. Aspects of the pathogenesis of the formation of neuropathic pain and the mechanisms of the effect of spinal cord stimulation are considered. The results of the studies evaluating the effectiveness of spinal cord stimulation in the most common types of neuropathic pain are presented.
The complex approach to assessing the treatment results of patients with paranoid schizophrenia
Authors: Samoylova Dariya Dmitrievna , Barylnik Yuliya Borisovna
Published: July 2021

The purpose of the study was the development of treatment results complex assessment scale based on the indicators of the traditionally used scales for dynamic observation and prediction of treatment outcomes for patients with paranoid schizophrenia. A total of 420 patients with paranoid schizophrenia (F20.0) were examined. During the study, an analysis of patients’ outpatient and inpatient cards and psychodiagnostic scales were carried out. Such aspects of patients’ life as social, cognitive and clinical ones were examined. It has been proposed and tested the author’s treatment results complex assessment scale, which covers all aspects of mental disorder in patients with schizophrenia. The developed scale of treatment results complex assessment provides a personalized approach to the management of patients with paranoid schizophrenia. Such complex assessment of the patients’ mental state helps to optimize the analysis of the effects of various therapies, simplify diagnostic tactics and personalize the treatment algorithm.
Application of different variants of endoscopic transphenoidal removal of corticotropinomas in order to increase the frequency and duration of remission
Authors: Ashraf A. , Chernov I. V. , Shkarubo A. N. , Kutin M. A. , Fomichev D. V. , Sharipov O. I. , Trunin Yu. Yu. , Andreev D. N. , Abdilatipov A. A. , Astafieva L. I. , Abdali B. , Kurnosov A. B. , Chmutin G. E. , Kalinin P. L. Kalinin P. L.
Published: July 2021

Itsenko-Cushing’s disease is a severe neuroendocrine disease caused by chronic hyperproduction of adrenocorticotropic hormone by a corticotrophic pituitary tumor (corticotropinoma). Surgical tumor resection remains the gold standard in the treatment of Itsenko-Cushing’s disease and leads to remission in 65–95 % of cases. Despite the benign nature of the disease, even in specialized neurosurgical centers, the recurrence rate of the disease is 25–35 % of cases. This paper presents an analysis of the effectiveness of various options for endoscopic transnasal removal of corticotropinomas, the selection of which was based on the topographic and anatomical features of the tumors. It was found that each of the surgical treatment options provides comparable results in achieving remission (from 81,3 to 87,9 %), while the most optimal method of surgical treatment in terms of recurrence-free survival and postoperative endocrine disorders is partial hypophysectomy, which will increase the likelihood of long-term remission of the disease.
The first recorded cases of mental disorders in the Russian Federation and federal districts in 2017-2019
Authors: Yazdovskaya Alla Vladimirovna , Demcheva Nadezhda Konstantinovna
Published: July 2021

The purpose of the study was to identify the main trends in the primary incidence of mental disorders in the Russian Federation in 2017–2019. The analysis of indices based on statistical reports, revealed changes in the direction of the dynamics of the primary incidence of mental disorders in the Russian Federation. In 2017–2019, the indicator increased (by 7,4 %) for the first time after a years-long (2005–2017) rather intense annual decline. The increase is observed in almost all federal districts of the country. The most noticeable increase is noted in the incidence of organic mental disorders, chronic inorganic disorders, childhood psychoses, including autism, as well as in indices in the groups of children and adolescents of 0–17 years old and individuals of 60 years and older. In conclusion, it was noted that the change in the dynamics of primary incidence in the Russian Federation observed in 2017–2019 is due to a number of factors: from organizational to social ones. As the most significant of them, early diagnosis and an increase in citizens’ referral to psychiatric institutions are noted.
Differentiated approach to plastic surgery of cerebrospinal fluid fistulas in the frontal sinus based on the analysis of computed tomograms
Authors: Shelesko Elizaveta Vladimirovna , Chernikova Nadezhda Alekseevna , Strunina Y. V. , Nikonova S. D. , Arslan Khanbagamaevich Abdulgamidov Arslan Khanbagamaevich Abdulgamidov , Kravchuk Aleksandr Dmitrievich , Zinkevich Denis Nikolaevich
Published: July 2021

The choice of the method of plasty of cerebrospinal fluid fistulas in the area of the frontal sinus is an important issue in neurosurgery, since there are a large number of anatomical variations in the structure of the naso-frontal canal and the sinus itself. Endoscopic, combined and transcranial approaches are described in the literature. However, there is no clear algorithm for choosing a surgical approach for nasal liquorrhea based on anatomical features. The objective of this article is to study various anatomical variants of the structure of the frontal sinus and nasolabial pocket in relation to defects of the base of the skull of a given localization and, based on the data obtained, to establish the patterns of the influence of certain indicators on surgical tactics and the quality of plastic to complement the proposed classification. This article include a retrospective analysis of case histories and computed tomograms of 38 patients who underwent surgical treatment for skull base defects in the frontal sinus region from 2010 to 2020. The patients were divided into three groups depending on the approach used, the features of intraoperative visualization of the defect, and relapses. In a series of 38 cases, the endoscopic approach was used in 26 (68.4 %) cases, combined in 12 (31.6 %) cases. The defect was completely visualized using angled optics during surgery in 32 (84.2 %) cases, and in 6 (15.8 %) cases the defect was not visualized or partially visualized (up to 50 %) using angled optics. Relapses were observed in 6 (15.8 %) cases. The main craniometric indicators affecting the choice of surgical tactics and the quality of plastics are the distance from the center of the defect to the nasal septum, the value of the angle between the nasal septum and the line drawn through the edges of the defect, and the size of the defect. The recurrence rate is directly related to the visualization of the defect during surgery. The distance from the defect to the nasal septum can serve as an objective indicator for choosing access to intermediate defects of the frontal sinus: at a distance of more than 0.95 cm, it is advisable to perform a combined approach; at a distance of less than 0.95 cm, it is possible to achieve full visualization of the defect and perform high-quality plastic surgery with an endoscopic approach.

English version of the article on pp. 244-253 is available at URL: https://panor.ru/articles/differentiated-approach-in-frontal-sinus-csf-fistula-plasty-based-on-computed-tomogram-analysis/63924.html
Concrescence of the cervical vertebrae and neurological complications
Authors: Yakhyaeva Sabiyat Abdulaevna , Garabova Naida Isagadzhievna , Burzhunova Madina Garunovna
Published: July 2021

In clinical practice, a sufficiently large number of patients complain of neurological disorders caused by osteochondrosis of the cervical spine. Despite this, in some cases, the development and progression of this symptomatology may be due to an anomaly in the structure of the cervical spine (Klippel-Feil syndrome), which is genetically determined. Timely diagnosis of this pathology with the implementation of complex research methods allows you to develop individual tactics for each individual patient, taking into account the severity of clinical manifestations to slow the progression of complications.
Mental disorders in a patient during the period of recovery after bilateral polysegmental viral pneumonia caused by COVID-19 (a clinical case)
Authors: Fon Ratenau Veronika Olegovna , Kushel Elena Viktorovna , Maksimov Mikhail Viktorovich , Suleymanov Roman Aleksandrovich , Artemieva Marina Stanislavovna Artemieva Marina Stanislavovna
Published: July 2021

None
Giant dermoid cyst of the brain: a clinical case and literature review
Authors: Zuev Sergey Evgenievich , Grin Andrey Anatolievich , Tokarev Aleksey Sergeevich , Evdokimova Olga Liverievna Evdokimova Olga Liverievna
Published: July 2021

The study objective to present a clinical case of patient with a giant brain dermoid cyst, as well as to analyze the literature data about this problem. Clinical case. The patient, 48 years old, with a giant dermoid cyst, complaints of headache, oculomotor disorders, underwent total microsurgical excision. In the long-term period after surgery, a complete resolution of neurological disorders was achieved, with a control MRI after 9 months, no recurrence of the disease was detected. Literature analysis. The analysis of the literature data was published during the thirty years from 1977 to 2017 revealed descriptions of intracranial dermoid cysts in 69 patients, determined the most frequent localization of cysts, the clinical status of the disease, outcomes of surgical treatment and prognosis of the disease. Results. The work demonstrates the results of surgical treatment of a dermoid cyst of the brain and a systematic analysis of the scientific medical literature data on this disease.
Intraoperative fluorescent angiography with indocyanine green in surgery of peripheral nerve injuries
Authors: Svistov Dmitry Vladimirovich , Isaev Dzhamaludin Magomedrasulovich , Gaivoronsky Alexey Ivanovich , Churikov Leonid Igorevich , Belyakov Kirill Vladimirovich
Published: July 2021

Despite the widespread introduction of microsurgical techniques in peripheral nerve surgery, a relatively high percentage of unsatisfactory results remains. Often, when treating patients with traumatic neuropathies, the surgeon faces the problem of diastasis between the ends of the damaged nerve. As a rule, in the presence of diastasis greater than 5 cm, it is recommended to perform inter-bundle autoneuroplasty. However, overcoming diastasis less than 5 cm may be accompanied by tension of the nerve trunk, which leads to a violation of its blood supply. In this case, the outcome of the intervention may be unsatisfactory, despite the operation performed perfectly from a technical point of view. An important factor of the outcome of surgical treatment of neuropathies of various origins is the preservation of adequate blood supply to the nerve trunk in the intraoperative period. In order to assess the blood flow in the nerve trunk, the possibility of using intraoperative fluorescent angiography for reconstructive surgical interventions on nerves was considered. In patients with a complete anatomical break of the large nerve trunk, at the moment of overcoming diastasis, intraoperative angiography of the nerve trunk was performed by intravenous administration of indocyanine green, with simultaneous registration of the tension force with which the nerve trunk was affected. In addition, fluorescent angiography was performed after the restoration of the integrity of the nerve trunk, thus assessing the safety, adequacy and effectiveness of blood flow in it. It was found that intraoperative angiography is an accessible and easily implementable technique to determine the safety and, not least, the adequacy and effectiveness of the blood flow in the nerve trunk, to study the mechanisms of compensation of blood supply to the nerve after microsurgical epineural suture, and to assess the quality of matching the stumps of the nerve axis, preventing the possibility of «torsion».
The level of carbonylation of plasma proteins and peripheral blood leukocytes in patients with different duration of Alzheimer’s disease
Authors: Petrov Dmitriy Sergeevich Petrov Dmitriy Sergeevich , Engalycheva Mariya Germanovna , Korotkova Natalya Vasilievna , Ochilov Ulugbek Usmanovich
Published: July 2021

The course of Alzheimer’s disease is associated with an increase in oxidative stress associated with an increase in the production of reactive oxygen species against the background of neurodegenerative inflammation, and a simultaneous depletion of the antioxidant defense capabilities of brain cells. The result is the oxidative modification of macromolecules: proteins, lipids, nucleic acids. Protein carbonylation products accumulate not only in neurons, and in direct correlation with the degree of increase in amyloidosis and neurodegeneration, but also in extra-neuronal tissues, including leukocytes. In the course of this study, the levels of spontaneous and induced oxidative modification of proteins were determined in the blood plasma and fractionated leukocytes of peripheral blood of patients with different durations of Alzheimer’s disease, and the value of the reserve-adaptive potential was assessed as markers of the severity of oxidative stress. It has been established that the course of Alzheimer’s disease has a greater effect on the accumulation of carbonyl derivatives in blood plasma. In patients with a disease duration of 5–10 years, the total level of aldehyde and ketone derivatives of modified plasma proteins exceeds the same indicator in subgroups with a shorter duration of the disease. This tendency is less typical for mononuclear leukocytes. The level of induced oxidative modification of proteins increases to a greater extent in blood plasma than in fractionated leukocytes. This indicates the depletion of the reserve-adaptive potential of plasma antioxidant capabilities, which is more pronounced in patients with a long course of Alzheimer’s disease. For polymorphonuclear leukocytes, such a pattern was not revealed, which is probably associated with a short cell life. In mononuclear leukocytes, as well as in plasma, there is a tendency to depletion of the reserve-adaptive potential, but to a lesser extent.
Sociocultural and biological factors in the development of eating disorders
Authors: Artemieva Marina Stanislavovna , Suleymanov Roman Aleksandrovich , Arseniev Aleksandr Romanovich Arseniev Aleksandr Romanovich , Danilin Ivan Evgenievich , Lazukova Anastasiya Gennadievna
Published: July 2021

The article provides an analysis of the data on the causes of the development of such a widespread pathology as eating disorders. The influence of various factors on the formation of this severe and difficultly curable pathology is being investigated. The article provides an overview of the literary data of the historical works and proceedings of the Department of the Peoples’ Friendship University of Russia, which was at the forefront of the study of this pathology. English version of this article on pp. 321-329 is available at URL: https://panor.ru/articles/revisiting-the-relationship-between-sociocultural-and-biological-factors-in-the-development-of-eating-disorders-55-year-experience-of-the-department-of-psychiatry-and-medical-psychology-pfur/63933.html
Management of patients with persistent and recurrent acromegaly
Authors: Ibrahim Sameh Ragab Awad , Shkarubo Aleksey Nikolaevich , Astafieva Lyudmila Igorevna , Chmutin Gennadiy Egorovich , Chmutin Egor Gennadievich
Published: July 2021

Acromegaly is a multisystem chronic disease characterized by hypersecretion of growth hormone. Effective treatment of acromegaly is extremely necessary, as this pathology is often associated with comorbid conditions (diabetes mellitus, arterial hypertension, sleep apnea syndrome, cardiac hypertrophy) and rare complete clinical and laboratory remission. This article describes treatment options for persistent and recurrent acromegaly that include surgery, pharmacological therapy and radiation therapy.
The severity of psychopathological symptoms in the population in the context of the COVID-19 pandemic
Authors: Belokrylov Igor Vladlenovich , Lineva Tatyana Yurievna , Bryukhin Andrey Evgenievich , Bocharnikova Aleksandra Andreevna , Batyrev Egor Igorevich , Okuneva Anastasiya Dmitrievna , Khrushch Inessa Anatolievna , Rakisheva Ak-Uke Salimzhanovna
Published: July 2021

This study assesses the severity of psychopathological symptoms among the groups in strict quarantine and the population without self-isolation in the context of the COVID-19 pandemic. From April 18 to June 15, 2020, an online survey was conducted using the symptomatic questionnaire (SCL-90-R) adapted by N. V. Tarabrina in a sample of 837 residents of Russia, Kazakhstan, Belarus and other states. 426 respondents followed the strict regime of self-isolation at home; 302 were on self-isolation, but could go to work; 109 were not subjected to self-isolation. As a result, the indices of anxiety, depression, somatization, obsessive-compulsive disorders, hostility, psychoticism, and the general index of severity were significantly higher in those in strict quarantine than in those without self-isolation (p<0.05). Therefore, there is a need to organize accessible psychiatric and psychological support for the population under conditions of quarantine.
Clinical case of Susac syndrome in a pregnant woman
Authors: Zakharycheva Tatyana Adolfovna , Otteva Elvira Nikolaevna , Shirokova Aleksandra Sergeevna , Litvinova O. V. , Polyakov A. G. , Snitko V. A. , Sobulyak V. O. , Chekurina S. L. , Yaitskaya E. O. , Syomova V. V.
Published: July 2021

A clinical case of a rare disease — Susak’s syndrome — in a 24-year-old patient is presented. The disease developed during pregnancy and was accompanied by vestibulo-ataxic and visual disturbances. The diagnosis was established based on the results of clinical and laboratory-instrumental examination — the presence of microangiopathy with predominant damage to the arterioles of the cochlea, retina and brain. The diagnosis was established according to the results of a clinical study and the results of neuroimaging — microangiopathy with a predominant lesion of the arterioles of the cochlea, retina and brain. The response to glucocorticosteroid therapy was obtained. The possible role of the SARS-CoV-2 beta coronavirus in the genesis of the disease is being discussed. Currently, the patient is under the supervision of a neurologist and a rheumatologist, taking prednisone.
Primary pituitary gland abscess in a 13-year-old girl. A clinical case description
Authors: Shkarubo Aleksey Nikolaevich , Zokhidov Zokirzhon Utkurovich , Livshits Matvey Igorevich , Levov Aleksandr Vyacheslavovich , Chmutin Egor Gennadievich , Berdieva Madina Golibovna , Chernov Ilya Valerievich , Ashurov Dzhalolboy Asrorovich , Kolcheva Mariya Andreevna , Musa Gerald , Berdinov Farkhad Bakhramdzhanovich
Published: July 2021

A primary abscess in the region of the Sella turcica is a rare neurosurgical pathology especially in the pediatric population. This pathology has no specific symptoms and may have an atypical presentation. It has no specific radiological features making diagnosis very difficult. In this article, we report on a 13-year-old girl with a confirmed primary pituitary abscess. Clinical and instrumental investigations as well as hormonal profile indicated a lesion of the Rathkes pouch- like a craniopharyngioma and to a lesser extent, a pituitary adenoma. In this case, laboratory and Magnetic resonance studies did not show any features of systemic or local acute inflammatory response respectively. The child underwent a surgery, during which the diagnosis was made — primary abscess of the pituitary gland.
The use of combined transcranial approaches in the surgical treatment of giant pituitary adenomas
Authors: Donskoy A. D. , Abdilatipov A. A. , Abdali Ashraf , Chernov Ilya V. , Chmutin Egor G.
Published: July 2021

The issue of total removal of giant pituitary adenomas remains relevant, despite all existing methods of surgical treatment. The use of a combination of transcranial approaches can increase the radicality and reduce the number of postoperative complications in the surgery of these tumors. In the practice of the N. N. Burdenko National Medical Research Center for Neurosurgery, a unique, previously not described experience of using this technique in 33 patients has been accumulated. There are no publications in the world scientific literature devoted to the analysis of the results of surgical treatment of patients with GPA operated on with combined transcranial approaches. In the presented work, the most relevant classifications related to giant pituitary adenomas are collected; the technique of performing combined transcranial approaches and the prospects for its study are indicated.
Acute symptomatic epileptic seizures in the early postoperative period
Authors: Fedorchenko Margarita Andreevna , Shnyakin Pavel , Isayeva Natalia Viktorovna , Yermilov Evgeny Aleksandrovich
Published: July 2021

The article provides an overview of recent studies related to epidemiology, diagnosis and treatment of acute symptomatic epileptic seizures (ASES)in the early postoperative period after brain intervention. Themain points distinguishing ASES fromseizures in epilepsy are highlighted. The initial condition of the patient, the reason for which the surgery was performed and the volume of the intervention are the main criteria that must be taken into account when assessing risk factors for epileptic seizures. An algorithm for managing a patient with ASES is presented.
Factors affecting the transformation of anaplastic glioma into glioblastoma
Authors: Medyanik Igor Aleksandrovich Medyanik Igor Aleksandrovich , Badu Simon Kwarteng
Published: July 2021

Despite being more favorable than glioblastoma, even after complex treatment, anaplastic glioma mostly progresses and transforms into glioblastoma in case of recurrence. The aim of this research was to study the clinical picture, survival rate and factors affecting the transformation of anaplastic glioma into glioblastoma. We studied the patients with anaplastic glioma, whose tumors transformed into glioblastoma, retrospectively from 2002 to 2020. The clinical picture and overall survival rate were studied. A total of 101 patients with anaplastic glioma, of which 29 transformed into glioblastoma (17 men and 12 women, with an average age of 48 years), were studied. The average time of glioblastoma transformation was 31 months. The overall survival was 44.50 months. The survival rate after the transformation was 13.5 months. The transformation of anaplastic glioma into glioblastoma affects the treatment protocol of patients, since the transformation is most often detected after the histology of re-resection has been confirmed. The treatment of anaplastic glioma should be individualized, taking into account molecular markers, age, and resection degree. Further research should also focus on the prevention or early treatment of transformed gliomas.
The features of emotional response in men in a sterile marriage
Authors: Gardanova Zhanna Robertovna , Petrov Nikita Igorevich , Khritinin Dmitriy Fedorovich
Published: July 2021

The problem of infertility treatment is currently relevant for married couples who have not had a pregnancy within a year of regular sexual activity. The possibility of infertility treatment using assisted reproductive technologies allows couples to get the desired pregnancy. The emotional response of men in infertile marriage was researched in this study, and it was shown that some men have an increased level of anxiety and depression, while preferred coping strategies allow going through the entire infertility treatment program, taking into account personal characteristics. The study involved 52 married men, aged 35-43 years. Psychodiagnostic testing using techniques to determine the level of anxiety, depression, coping strategies, and a personal questionnaire was conducted. As a result of the obtained data, the need for psychodiagnostic testing is justified in order to identify the level of emotional expression and the possibility of participation in the ART program.
Subcortical lesions in various phenotypes of multiple sclerosis and their prognostic significance
Authors: Poplyak Mariya Olegovna , Trufanov Artem Gennad’evich , Aleksandr Vasil’evich Temniy Aleksandr Vasil’evich Temniy , Efimtsev Aleksandr Yur’evich , Chakchir Oleg Borisovich , Miheev Alexei Vladimirovich , Skulyabin Dmitrij Igorevich , Kuznetsova Evgeniya Viktorovna , Bisaga Gennady Nikolaevich , Litvinenko Igor’ Vyacheslavovich , Odinak Miroslav Mihailovich
Published: July 2021

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease that affects the central nervous system, mainly in young people, and leads to inevitable disability. The purpose of the study is to determine the degree of involvement of subcortical structures in the pathological process in multiple sclerosis and to assess their prognostic significance. 80 patients with relapsing-remitting (n=48) and secondary progressive (n=32) phenotypes of MS were examined; the control group consisted of 20 healthy people of the corresponding age and gender. Clinical assessment was carried out on the following scales: EDSS, MSSS, MMSE, FAB, MoCA, SDMT, Beck’s test and HADS. All patients underwent MRI of the brain and MR-morphometry using the Freesurfer 6.0 software. In patients with multiple sclerosis, the neurodegenerative process is represented by a decrease in the volumes of the caudate nucleus and putamen, an increase in the volume of the third and lateral ventricles, an increase in CSF volume, and the presence of «black holes». The volume of the third and lateral ventricles, as well as the volume of CSF (general neurodegeneration), depends on the duration of the disease. The degree of disability (EDSS) is influenced by the volumes of the caudate nucleus, globus pallidus, nucleus accumbens, and brainstem. In turn, cognitive decline is influenced by the volume of the thalamus, basal nuclei, brainstem, the volume of the lateral ventricles, and a decrease in the volume of the white matter and cerebellar cortex. Thus, dynamic assessment and monitoring of the volume of subcortical structures of the brain using MR-morphometry can act as a prognostic factor in the transition of the relapsing-relapsing phenotype of multiple sclerosis to the secondary progressive phenotype.

English version of this article on pp. 404-411 is available at URL: https://panor.ru/articles/subcortical-brain-lesions-in-different-phenotypes-of-multiple-sclerosis-and-their-prognostic-significance/63941.html
Epidermoid brain cysts: a case report and a literature review
Authors: Shpagin Maksim Vladimirovich , Yarikov Anton Viktorovich , Nikitin Denis Nikolaevich , Lobanov Igor Anatolievich , Laganin Ivan Aleksandrovich , Koritko Yuriy Leontievich , Maksim Sergeevich Popov Maksim Sergeevich Popov , Fraerman Aleksandr Petrovich
Published: July 2021

The article is devoted to rare brain pathology, i.e. epidermoid cysts. The histological picture of the tumor is described; the classification is given. On the basis of our own clinical observations and a literature review, the features of the clinical manifestations of cholesteatoma of the cerebellopontine angle, modern approaches to the diagnosis and tactics of complex treatment are presented.
Practical experience of using disease-modifying drugs for lumbosacral dorsalgia
Authors: Andreev Vladislav Viktorovich
Published: July 2021

Pain in the lumbosacral localization occurs in more than 70% of people and the main contingent of those who seek medical help are patients of working age [1]. The causes of its occurrence are degenerative and dystrophic processes of intervertebral discs and facet joints and muscle tonic reactions. Combined disease-modifying drugs (chondroprotectors) are highly effective in the complex treatment of such diseases. In a group of 39 patients, a study was conducted of the efficiency of the use of modern chondroprotector Flexinovo for nonspecific pain in the lower back, 1 tablet per day for 3 months, with an assessment of the patient's condition during 6 months. A statistically significant decrease in pain intensity according to a visual analogue scale is achieved by the end of the course of treatment, with an increase in the effect by the end of the observation from 6.00 (5.00; 6.00), pc-6m <0.001Z, 4.50 (4.00; 6.00), p3m-6m <0.001 and 1.00 (1.00; 2.25), respectively. Also, the intensity of neuropathic pain decreases according to the DN4 scale, with dynamics from the moment of screening (3 (2; 3), pc-3m <0.001) to the end of the drug use (1 (1; 2) and follow-up 1 (1; 2), (p3m-6m = 0.46). During the observation period, there was a positive effect on the quality of life according to the SF-36 scale with an improvement in general health parameters over time from 52 (50; 62) to 72 (72; 77), respectively (p <0.001). Less pronounced improvements were noted in this sample on the scale of emotional functioning - 33.3 (33.3; 66.7) and 66.7 (66.7; 100), accordingly (p <0.001). All the studied patients showed clinically significant satisfaction with the treatment.
The comparative analysis of clinical and social characteristics of patients with schizophrenia and organic mental disorders receiving care in partial inpatient units
Authors: Kostyuk George Petrovich , Burygina Larisa Andreevna Burygina Larisa Andreevna , Berezantsev Andrey Yurevich , Surikova Valeriya Vasilyevna
Published: July 2021

The article presents the results of a comparative analysis of the clinical and social characteristics of patients with schizophrenic spectrum disorders (SSD) and organic mental disorders (OMD) who received care in day hospitals and intensive psychiatric care units (Moscow). During the study, a random sample of 487 discharge epicrises was studied, of which 392 (80,49%) were patients with SSD and OMD, who were subjected to further analysis. The study revealed gender differences and low rates of labor and family adaptation in both nosological groups of patients. The highest percentage of patients observed on a long-term basis in neuropsychiatric dispensaries and the rate of hospitalization in a round-the-clock inpatient unit were among the patients with diagnoses of schizophrenic spectrum disorders who were treated in intensive psychiatric care units. There were significant differences in the routing of patients depending on the pathology: district psychiatrists more often refer patients with a diagnosis of schizophrenia to the intensive psychiatric care unit in order to prevent hospitalization and patients with organic mental disorders - to day hospitals for therapy selection and medical and social rehabilitation, while doctors of the round-theclock hospital – vice versa (in order to continue treatment or follow up in out-of-hospital conditions). There was also a circulation of patients between the intensive psychiatric care unit and the day hospitals. Isolated episodes of compliance violations were noted. Indicative indicators such as hospitalization in a round-the-clock psychiatric inpatient unit within a year after the discharge from partial inpatient units was low and was usually due to severe continuous forms of the disease and the formation of therapy resistance in patients. Day hospitals and departments (offices) of intensive psychiatric care in general effectively perform the functions of inpatient unit substitution.
Engineering facilities for the nursery and mother plant garden of the common hazel (Corylus avellana l.)
Authors: Gadzhiev R.K. , Kataeva M.V. , Kuchiev S.E.
Published: July 2021

The article deals with the issues of engineering arrangement of the territory for the nursery and the mother plant garden of common hazel - the layout of the nursery, the choice of the irrigation method, the calculation of the reservoir volume, irrigation rates, and production efficiency.
Problems of the measurement management systems evaluation for business entities on voluntary basis
Authors: Chyzhyk Ivan , Danylina Iryna
Published: July 2021

Questions concerning evaluation and confirmation of measurement capabilities for business entities on a voluntary basis are considered.

Existing problems in executing this kind of activity by enterprises, which are regulated by the Ministry of Economy of Ukraine (metrological centers) as well as other enterprises and organizations.

Causes of impossibility to issue certificates on compliance of the measurement management systems with requirements of DSTU ISO 10012 as a result of providing the above-mentioned operations are determined.

The ways of solving the determined questions for metrological centers are proposed.
Comprehensive analysis of former and new methods on conformity establishment of measuring instruments
Authors: Cherepkov Serhii , Dulia Valerii , Maliavskyi Valerii , Solomakhina Olena
Published: July 2021

Taking into account five-year experience in measuring instruments conformity assessment with technical regulations requirements, gradual shift from the former system of testing and control to the new methods is considered according to the new Law of Ukraine «On metrology and metrological activity», which is harmonized with European Laws on metrology. Advantages of the system for measuring instruments conformity assessment with technical regulations requirements were determined and analyzed for instruments manufacturers and customers.
Measurement Standards of Ukraine for Gas Volume Flow Rate at Pressures of 1 MPa to 5 MPa
Authors: Rozhnov Mykhailo , Melnyk Dmytro , Levbarg Ovsiy
Published: July 2021

The characteristics of the primary measurement standards of the volume gas flow rate at high pressure developed in various countries are considered. A hierarchical scheme for gas flow measuring instruments and a corresponding metrological traceability chain are presented. Described is a PVTt method, on which the primary standards of gas flow rate used in the USA, France, Japan, and Taiwan are based. The need to create in Ukraine primary measurement standards of gas flow rate at high pressure covering different parts of the total flow rate interval from 0,3 m3/h to 1800 m3/h at a pressure of 1 MPa to 5 MPa is substantiated. Metrological traceability of gas flow measurements is realized through a sequence of critical flow Venturi nozzles, which play a role of the reference flow rate material measures. The standards might be used to calibrate the primary reference Venturi nozzles of the most common 0,1 mm to 8 mm diameters. The characteristics and parameters of the standards are determined. By their metrological and technical characteristics, the standards will correspond to the state-of-the-art level. According to the programme of developing the measurement-standard facilities in Ukraine, in 2019 the primary standard PVTt-65 was created and work had started on the development of the primary standard PVTt-1800 and the working standard PE-5400. A detailed study of the metrological characteristics of the measurement standards will be the topic of further work.
Alternative approach to international comparisons
Authors: Samoilenko Oleksandr
Published: July 2021

According to the authors point of view, absence of the accepted by metrological society software based on simple and understandable and at the same time flexible and multipurpose mathematical apparatus is one of the restrictions on the way to arrangement of international comprehensive comparisons with expanded group of participants (hereinafter — comprehensive comparisons). General methodology of measurements adjustment by the least square method (LSM) may be used for this mathematical apparatus.

Software named «Metrology Network» is defined. It was used for repeated processing of measurement results during the key comparisons of EURAMET.L-K1.2011 «Measurement of gage blocks by interferometer». «Metrology Network» software allowed to estimate simply and quickly systematic measurement error components of the gage blocks length measurement by each laboratory. They are called multiplicative and additive measurement standards degrees of equivalence. «Metrology Network» allowed to estimate strictly by LSM the uncertainties of length measurement. Additive degrees of equivalence are considered substantial and constant characteristics of the measurement standards for many laboratories. Thus, they coincide for steel and ceramic gage blocks. These additive degrees of equivalence may be used as corrections in the process of calibration or as the reference values for further comparisons.

The simulation of measurement results for international comprehensive comparisons with complicated structure was provided. For 120 laboratories divided into 12 groups, totally 2442 length measurements of the steel or ceramic gage blocks were provided. They form together 24 sets of 8 gage blocks and provide 24 loops of comparisons. Necessity to provide the adjustment by the least square method is caused by the fact that two subgroups from each group of three laboratories took part in two different related loops of comparison. As a conclusion, «Metrology Network» software easily managed this complicated task of adjustment.  It allowed us to calculate each of 120 measurement standards additive degree of equivalence relative to the averaged zero for all measurement standards and multiplicative degree of equivalence relative to the averaged measurement unit.
Planning and Reporting Method Validation Studies Print Email. A Supplement to the Eurachem Guide «The Fitness for Purpose of Analytical Methods»
Authors: Levbarg Ovsiy
Published: July 2021

Ukrainian translation of The Fitness for Purpose of Analytical Methods - A Laboratory Guide to Method Validation and Related Topics (2nd ed.), which was published in 2014, is offered. Since Document publication the Method Validation Working Group has identified areas where extra guidance would be appropriate. This extra guidance has been prepared in the form of supplementary documents, which should be used in conjunction with the Guide. Original Document is published on the Euracem website. https://www.eurachem.org/index.php/publications/guides/planning-validation-studies
DYNAMIC LOADING OF THE ROD IN CASE OF A SUDDEN CHANGE IN THE STRUCTURE OF THE ELASTIC BASE
Authors: PODDUBNY А.А. , GORDON V.A. , POTURAEVA T.V.
Published: July 2021

A mathematical model of the dynamic process in the structurally nonlinear system «beam – two-parameter foundation», which arises as a result of a sudden change in the physical and mechanical properties of the foundation, leading to zeroing of its shear stiffness, is constructed in a structurally-nonlinear system «beam – two-parameter foundation» The solution of the static problem of bending of a beam supported on a Pasternak base serves as the initial condition for the problem of forced vibrations of a beam on a Winkler base that arose after the sudden formation of a defect. Solutions to static and dynamic problems are constructed by the method of initial parameters with the use of vectors of states of beam sections and matrices of the influence of initial parameters on the state of arbitrary sections. In the analysis of forced vibrations, the decomposition of the load and deflections of the initial static state into rows according to the forms of natural vibrations of the new state is used.
Gestão na educação infantil
Authors: Galisteu Renata Boiatti Migliorança , Nono Maévi Anabel
Published: July 2021

Neste artigo são apresentados resultados de pesquisa de mestrado que focalizou a gestão na Educação Infantil, mais especificamente na pré-escola, a partir da investigação dos saberes de diretoras de escola sobre sua profissão. A especificidade da gestão nessa etapa da Educação Básica e a importância dos diretores de creches e pré-escolas no estabelecimento de uma Educação Infantil de qualidade vêm sendo apontadas em estudos recentes, assim como lacunas nas pesquisas nessa área (KRAMER, 2011; FERNANDES; CAMPOS, 2015; CAMPOS et al., 2012). O estudo aqui relatado, de natureza qualitativa (ANDRÉ, 2013), teve como objetivo identificar, do ponto de vista dos sujeitos, saberes necessários para sua atuação na gestão de pré-escolas, além de contribuições e limitações de seus cursos de formação inicial e continuada para a atuação como diretora de escola que atende crianças de quatro a cinco anos. Foram entrevistadas sete diretoras de pré-escolas de um município de médio porte do noroeste paulista. Resultados apontam para a necessidade de políticas de formação dessas profissionais que focalizem a especificidade da gestão nas instituições que atendem crianças pequenas.
Significações de jovens gays ricos e pobres sobre a masculinidade na escola
Authors: Amaral Marcos Martins , Bock Ana Mercês Bahia
Published: July 2021

Este artigo apresenta pesquisa realizada sobre o papel da escola na constituição da masculinidade gay. Para isto estudamos as significações constituídas por estudantes autodeclarados gays, suas experiências e vivências na escola, enfocando a constituição de sua orientação sexual. O estudo considerou também o fato de vivermos em uma sociedade marcada pela desigualdade social, acreditando que este aspecto poderia ser determinante nas experiências e significações. Foram realizadas conversações com dois grupos de adolescentes homens autodeclarados gays, pobres e ricos, do Ensino Médio da cidade de São Paulo. As conversações foram analisadas a partir da perspectiva da Psicologia Sócio-Histórica e do procedimento de constituição de Núcleos de Significação. O movimento dialético de análise nos permitiu afirmar que a escola é uma instituição social importante na constituição da masculinidade dos adolescentes gays e precisa superar, institucionalmente, o seu estranhamento às funções sociais que lhe cabe.
Contação de histórias
Authors: Santos Andréia de Araújo , Oliveira Rosemary Lapa de
Published: July 2021

A contação de histórias (CH) faz parte da vida do ser humano e do seu processo de humanização, na medida em que simboliza a relação do homem com a linguagem e suas formas de representação – entre elas, as pinturas rupestres, os grunhidos e a fala propriamente ditos. Com o passar do tempo, a contação de histórias foi ganhando outros sentidos e outros espaços, conforme o ser humano passou a explorá-los e a ocupá-los. Assim, o objetivo desta investigação foi de saber quais as concepções de contação de histórias emergiam dos trabalhos acadêmico-científicos produzidos nas Ciências Humanas e os aspectos da oralidade que subjaziam a essas concepções. Para a consecução de tal objetivo, foram realizadas uma pesquisa exploratória de base bibliográfica e uma revisão integrativa, com abordagem quanti-qualitativa, para identificar os conceitos de literatura infantil e de contação de histórias, na base de dados da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Neste trabalho, considera-se que a contação de histórias e a literatura infantil são associadas a uma utilização que precede uma atividade de ensino e ratifica que sua concepção é educativa. Esses resultados possibilitam inferir que, apesar da relevância da contação de histórias, defendida pelos autores que embasaram este estudo, ela ainda é marginalizada, porque se enfatizam a leitura e a escrita em detrimento da oralidade. Destarte, este trabalho contribui para ampliar a discussão sobre a compreensão do espaço que a contação de histórias ocupa na sociedade.