bluuebunny/crossref_metadata_2025 huggingface dataset:
Investment Activity in the Border Territories of Ukraine and Directions of Its Activation
Authors:   Lviv Polytechnic National University, Andrushkiv I. P.
Published: August 2021

The article examines the directions of activation of investment activity in the border territories of Ukraine. The problems and obstacles to investment activity in the border regions are identified and directions of its activation are outlined. It is specified that in the process of international cooperation, including the cross-border activities, border territories play an important role and have a specific status. Regions at the present stage of economic development begin to play a significant economic, social and technological role in the formation of the territorial infrastructure of each particular country. The concepts of investment, investment climate, border region are considered. The factors of influence on the level of investment attractiveness of border regions are determined. A characterization of capital investments in the border regions of Ukraine is carried out. It is noted that the border regions have great potential for the development of investment activity, and their geographical location creates additional advantages. Priority directions of activation of investment processes in border regions and priority directions of developoing the investment potential, which would contribute to the increase of investments in border regions, are presented. It is concluded that investment is the dominant factor in the socio-economic growth of the border regions and the State in general. That is why conditions should be created at the State level that will increase investment attractiveness and, as a result, intensify investment activity. This will ensure active participation of the border regions of Ukraine in the processes of integration into the EU.
Efektifitas Progressive Muscle Relaxation (PMR) Terhadap Tekanan Darah Pada Penderita Hipertensi Di Desa Banjarsari Serang Banten
Authors: Zainaro M Arifki , Tias Sekardhyta Ayuning , Elliya Rahma
Published: August 2021

ABSTRAKHipertensi merupakan suatu keadaan meningkatnya tekanan darah sistolik lebih dari sama dengan 140 mmHg dan diastolik lebih dari sama dengan 90 mmHg. Beberapa penanganan dalam hipertensi yaitu penanganan non farmakologis yaitu teknik relaksasi napas dalam, pijat refleksi kaki, hipnoterapi dan relaksasi otot progresif (Progressive Muscle Relaxation), beberapa keistimewaan dari teknik relaksasi otot profresif ini yaitu menurunkan ketegangan otot, sakit kepala, menurunkan tekanan darah sistolik dan diastolic. Tujuan penelitian, untuk mendapatkan pengalaman dan kompetensi lebih dalam pemberian asuhan keperawatan komprehensif pemberian terapi Progressive Muscle Relaxation (PMR)  terhadap penurunan tekanan darah. Adapun kegiatan yang dilakukan berupa penyuluhan menggunakan leaflet dan demonstrasi terapi Progressive Muscle Relaxation (PMR). Terdapat penurunan tekanan darah setelah dilakukan terapi Progressive Muscle Relaxation (PMR) pada penderita hipertensi. Dengan demikian, terapi Progressive Muscle Relaxation (PMR) sangat efektif dalam menurunkan tekanan darah.                                                                                            Kata Kunci: Progressive Muscle Relaxation (PMR), Hipertensi, Tekanan Darah ABSTRACTHypertension is a state of increased systolic blood pressure of more than 140 mmHg and diastolic more than equal to 90 mmHg. Some treatments in hypertension are non-pharmacological treatments namely deep breathing relaxation techniques, foot reflexology massage, hypnotherapy and progressive muscle relaxation (Progressive Muscle Relaxation). diastolic. The goal of the study was to gain more experience and competence in the provision of comprehensive nursing care in the provision of Progressive Muscle Relaxation (PMR) therapy for reducing blood pressure. The activities carried out in the form of counseling using leaflets and demonstrations of Progressive Muscle Relaxation (PMR) therapy. There is a decrease in blood pressure after Progressive Muscle Relaxation (PMR) therapy in patients with hypertension. Thus, Progressive Muscle Relaxation (PMR) therapy is very effective in lowering blood pressure. Keywords: Progressive Muscle Relaxation (PMR), Hypertension, Blood Pressure
Pengaruh Pemberian Stimulasi Tumbuh Kembang Anak Pada Usia 36 Bulan Pada An. K Di Kelurahan Sumberejo Kemiling Bandar Lampung
Authors: Setiawati Setiawati , Binhar Reni Aprilia , Novikasari Linawati
Published: August 2021

ABSTRAK Keterlambatan perkembangan anak pada aspek tertentu saat ini masih menjadi slah satu masalah kesehatan bagi anak di Indonesia yang dapat mengurangi kualitas sumber daya manusia di masa mendatang. Melakui pendekatan famly cantered-care orang tua anak dapat melakukan intervensi dini terhadap masalah keterlambatan perkembangan anak sebagai upaya pencegahan terhadap keterlambatan perkembangan anak lebih lanjut dengan pemberian stimulasi perkembangan terarah selama 2 minggu. Stimulasi adalah perangsangan dari luar lingkungan anak dimana dengan mengasah kemampuan anak secara terus-menerus kemampuan anak dimana dengan mengasah kemampuan anak secara terus-menerus kemampuan anak akan meningkat. Kata kunci : Anak Praskolah, Keterlambatan Perkembangan Anak, Stimulasi Perkembangan  ABSTRACT The delay in children's development on specific aspects is still one of the health problem for Indonesian children which can reduce the quality of the human resources in the future. Through a family-centered-care approach, parents will be able to do early intervention for the delay in children development problem prevention against further delay in children development with a directional development stimulation for 2 weeks. Stimulation was an external environment stimulation inability. Keyword: Preschool Children, Children’s Delay Development, Development Stimulate
Pemberdayaan Akseptor Dan Kader Mengenal Efek Samping Kontrasepsi Hormonal Di Pustu Tanjung Kabupaten Ende
Authors: Bedho Martina , Owa Khrispina , Woge Yoseph , Sawa Fitria Syafrudin Pua
Published: August 2021

ABSTRAK Peserta KB aktif dan akseptor KB baru di kabupaten Ende 53,2 %, lebih memilih menggunakan alat kontrasepsi hormonal sedangkan pemilihan alat kontrasepsi lain berada dibawah 20%. Alat kontrasepsi suntik yang paling banyak digunakan, berikutnya implant dan pil. Akseptor yang mengalami efek samping kenaikan berat badan dan hipertensi 32 orang (11,03%), dan akseptor terbanyak berada di Puskesmas pembantu Tanjung. Tujuan pengabdian masyarakat ini adalah pemberdayaan akseptor dan kader kesehatan mengenal efek samping penggunaan kontrasepsi hormonal, dimana sasarannya adalah kader dan akseptor. Metode yang digunakan adalah screening,ceramah, diskusi, simulasi dan praktikum oleh khalayak sasaran. Hasil pengabdian masyarakat menunjukan semua akseptor memiliki pengetahuan baik (83,33%) pada pretest sedangkan posttest (100%) namun belum tahu tentang lama penggunaan kontrasepsi hormonal baik secara suntik, implant dan pil. Keterampilan yang dicapai adalah semua kader dan akseptor 28 orang (100%) dapat mengukur tinggi badan, menimbang berat badan, dan mengukur tekanan darah. Diharapkan pengamatan yang intensif dari bidan Pustu Tanjung dan dapat diperdaya oleh kader KB untuk membantu mengawasi efek samping kontrasepsi hormonal. Kunci : Pemberdayaan akseptor dan kader, efek samping kontrasepsi hormonal.                                    ABSTRACT 53.2% of active family planning participants and new family planning acceptors in the Ende district prefer to use hormonal contraceptives while the choice of other contraceptives is below 20%. The most widely used injectable contraceptives are implants and pills. There were 32 acceptors who experienced side effects of weight gain and hypertension (11.03%), and the most acceptors were in the Tanjung auxiliary health center. Research in Kumasi sub-district, Ghana, India, because some acceptors experienced long and heavy menstruation, spotting, no menstruation, and vaginal discharge so they were afraid of modern contraceptive methods (Kimberly Daniels, 2015). The aim of this community service is to empower acceptors and health cadres to recognize the side effects of using hormonal contraceptives, where the targets are cadres and acceptors. The methods used are screening, lectures, discussions, simulations, and practicum by the target audience. The results of community service show that all acceptors have good knowledge (83.33%) at pretest while posttest (100%), but they do not know about the length of time using hormonal contraceptives both by injection, implant, and pill. The skill achieved is that all 28 cadres and acceptors (100%) can measure height, weight body weight, and measure blood pressure. It is hoped that intensive observation from the midwife of Pustu Tanjung and the family planning cadres can help to monitor the side effects of hormonal contraception. Keywords:  Empowerment of acceptors and cadres, side effects of hormonal contraception.
Edukasi Literasi Keuangan Dan Pelatihan Komunikasi Terapeutik Di Stik Sint Carolus, Jakarta
Authors: Hermawan Francisca , Wijayanti Sri Hapsari` , Saadah Siti , Putranto Ambrosius Aprian Tri
Published: August 2021

ABSTRAK Mahasiswa lulusan kebidanan perlu dipersiapkan untuk terjun ke masyarakat dalam berbinis atau berkarier. Kebutuhan akan pemahaman literasi keuangan dan kemampuan berkomunikasi di tempat mereka akan bekerja sangat dibutuhkan. Karena  itu kegiatan ini bertujuan  mengedukasi literasi keuangan dan memberikan pelatihan komunikasi terapeutik. Target program ini adalah mahasiswa dan dosen STIK Sint Carolus berjumlah dua puluh orang. Melalui metode tutorial dan diskusi, peserta kegiatan ini menyambut baik dan antusias materi yang disajikan karena relevan dengan kebutuhan mereka saat ini dan masa depan. Mahasiswa mempunyai peluang karier yang besar untuk menjadi wirausahawan dalam bidang pengelolaan klinik kebidanan. Begitu pula mereka akan melayani pasien dan bekerja sama dengan  sesama bidan atau dokter untuk menjadi bidan yang terampil. Kegiatan ini menunjukkan adanya minat peserta untuk memahami lebih dalam tentang literasi keuangan dan komunikasi terapeutik.  Kata Kunci: Literasi Keuangan, Komunikasi Terapeutik, STIK Sint Carolus.  ABSTRACT   Students are an asset to be prepared to enter the workplace as a businessman or get the high career. The need for an understanding of financial literacy and the ability to communicate in their world of work is urgently needed. Therefore this activity aims to educate financial literacy and provide therapeutic training. The target of this program is twenty students and lecturers of STIK Sint Carolus. Through tutorial and discussion methods, participants in this activity welcomed and were enthusiastic about the material presented because it was relevant to their needs today and in the future. Students have great career opportunities to become entrepreneurs in the management of midwifery clinics. Likewise, they will serve patients and work together with peers or doctors to become professionals. This activity showed the participants' interest in understanding more deeply about financial literacy and therapeutic communication.  Keywords: Financial Literacy, Therapeutic Communication, STIK Sint Carolus.
Perlindungan Masyarakat Pidie Dari Covid-19 Melalui Pemakaian Masker
Authors: Rahmi Lisa , Raihanah Cut , Miniharianti Miniharianti , Sahara Tuti , Hijriana Isni , Yusnita Yusnita
Published: August 2021

ABSTRAK Virus corona (COVID-19) dapat menyebar melalui percakapan dan pernapasan normal dengan orang yang terpapar. Salah satu cara untuk mencegah terjadinya penularan COVID-19 adalah melalui pemakaian masker. Hal ini sejalan dengan imbauan Pemerintah untuk menerapkan protokol kesehatan pencegahan COVID-19, salah satunya melalui pemakaian masker kain untuk masyarakat umum. Tujuan pengabdian masyarakat ini adalah meningkatkan kesadaran masyarakat Pidie untuk menggunakan masker kain ketika melakukan aktivitas di luar rumah sebagai pencegahan penyebaran COVID-19 serta memberikan penjelasan mengenai cara menggunakan masker kain yang benar di saat melakukan aktivitas di luar rumah selama masa pandemi COVID-19. Kegiatan ini berlangsung pada tanggal 22 April 2020 di Simpang 4 Kota Sigli dengan cara membagikan masker kain kepada masyarakat Pidie yang beraktivitas di luar rumah disertai dengan sosialisasi tentang cara pemakaian masker kain yang benar. Antusias masyarakat Pidie dalam menerima edukasi dan pembagian masker kain terlihat selama kegiatan ini. Diharapkan kesadaran masyarakat Pidie untuk selalu menggunakan masker kain ketika beraktivitas di luar rumah semakin meningkat sehingga dapat menurunnya resiko penyebaran COVID-19 di lingkungan masyarakat Pidie yang harus tetap beraktivitas di luar rumah. Kata Kunci : Pencegahan, COVID-19, Pemakaian Masker, Masyarakat Pidie    ABSTRACT The coronavirus (COVID-19) can be spread through interacting and normal breathing with exposed people. One of the ways to prevent the transmission of COVID-19 is through wearing masks. This is in line with the government's appeal to implement health protocols for the prevention of COVID-19, one of which is through wearing cloth masks for the general public. The aim of this community service is to increase the awareness of the Pidie community to use cloth masks when carrying out activities outside the home as a prevention of the spread of COVID-19 and to provide an explanation of how to use the correct cloth masks when doing activities outside the home during the COVID-19 pandemic. This activity took place on April 22, 2020, at Simpang 4, Sigli City by distributing cloth masks to Pidie people who had activities outside the home accompanied by socialization on how to use cloth masks correctly. The enthusiasm of the Pidie community in receiving education and distributing cloth masks was seen during this activity. It is hoped that the awareness of the Pidie community to always use cloth masks when doing activities outside the home will increase so that it can reduce the risk of spreading COVID-19 in the Pidie community who have to continue their activities outside the home. Keywords: Prevention, COVID-19, Use of Masks, Pidie Society
Sosialisasi pencegahan Covid-19 melalui mencuci tangan, memakai Masker dan Social Distancing
Authors: Sari Liya Lugita , Rossita Taufianie
Published: August 2021

ABSTRAK Kasus baru Covid-19 tercatat sebanyak 6.894 dengan total kasus 23 Februari-08 Maret 2020 sebanyak 97.723 orang. Dalam hal ini kasus covid-19 belum mengalami penurunan yang tajam. Bengkulu selatan sendiri masih memiliki resiko sedang kenaikan kasus terhadap penularan covid, ini menandakan bahwa belum meredanya kasus covid-19 di Bengkulu Selatan. Tujuan setelah sosialisasi dan penyuluhan singkat, diharapkan dapat meningkatkan pengetahuan dan kemampuan siswa untuk melakukan pencegahan covid-19 di SDN 04 Manna Bengkulu Selatan. Adapun kegiatan yang dilakakukan adalah penyuluhan dan sosialisasi menggunakan infokus dan praktik Mencuci tangan serta social distancing yang benar. Terdapat pengingkatan pengetahuan dan kemampuan tentang pencegahan covid-19 pada murid SD di SDN 04 Manna, Bengkulu Selatan. saran untuk guru yaitu selalu mengingatkan siswa untuk melakukan pencegahan covid-19 dengan selalu cuci tangan pada saat masuk ke kelas dan sebelum memegang mulut, hidung dan mata, menggunakan masker yang benar dan selalu menjaga jarak Kata Kunci : Sosialisasi, Cuci Tangan, Penggunaan Masker, Social Distancing ABSTRACTNew cases of Covid-19 were recorded as 6,894 with a total of 97,723 cases from February 23 to March 08, 2020. In this case, the case of covid-19 has not experienced a sharp decline. South Bengkulu itself still has a moderate risk of increasing cases against the transmission of covid, this indicates that there has not been an easing of covid-19 cases in South Bengkulu. The goal after socialization and short counseling is expected to improve students' knowledge and ability to prevent covid-19 at elementary school 04 Manna Bengkulu Selatan. The activities carried out are counseling and socialization using infocus and the practice of handwashing and social distancing properly. There is an increase in knowledge and ability about covid-19 prevention in elementary school students at elementary school 04 Manna, South Bengkulu. advice for teachers is always to remind students to take covid-19 prevention by always washing their hands when entering the classroom and before holding their mouth, nose, and eyes, using the correct mask, and always keeping their distance. Keywords : Socialization, Hand Wash, Use of Masks, Social Distancing
Stress Management In Women Working During The Covid-19 Pandemic In Sidokumpul Village, Bungah, Gresik
Authors: Septianingrum Yurike , Wijayanti Lono , Wardani Erika Martining
Published: August 2021

The dual role of being a mother and a worker gives stress to women who live it. The demand to work at home becomes a burden for them because they have to optimize their roles both as mothers and as workers, especially in conditions of imbalance in the work environment due to the current Covid-19 pandemic. The mother's inability to cope with the stressors received has the risk of causing depression in the mother. This community service aims to increase the knowledge of mothers about stress management in working mothers during the Covid-19 pandemic. The activities are carried out within 1 month. The method used is education and demonstration of positive thinking virtually via YouTube. This community service activity was attended by 17 mothers. Mother's knowledge was measured using a questionnaire via a google form. The results of community service show that there is an increase in knowledge of mothers after being given virtual counselling
Clinical Characteristic of Congenital Fetal Anomaly In Tertiary Referral Hospital in East Java, Indonesia
Authors: Amani Fariska Zata , P Wardhana M. , I Cininta N. , A Aryananda R. , E Gumilar K. , I Aldika M. , B Wicaksono , Ernawati Ernawati , A Sulistyono , Aditiawarman Aditiawarman , J Hermanto T. , N Abdullah , G Dachlan E
Published: August 2021

Background: Congenital fetal anomalies were defined as any structural defect present at birth. Congenital fetal anomalies are an important causes of neonatal morbidity and mortality in developed and developing countries that affect health care system. Reliable data on these congenital anomalies are still lacking, especially in Indonesia. Objective: This study aims to determine the characteristic profile of congenital fetal anomaly in single tertiary hospital in East Java, Indonesia. Methods: Retrospective cross-sectional by using medical record data of dr. Soetomo General Hospital on January – December 2017. Results: There were 58 cases (4,3%) with fetal congenital anomaly from 1360 deliveries in 2017. The majority of cases were referral cases (51 cases; 88%) and only seven cases were booked cases in obstetric outpatient dr. Soetomo General Hospital. Most of these congenital fetal anomaly cases ( 25 cases / 43,1%) were born from mother with ages 20 – 30 years old. Most cases (34 cases; 58,64%) were diagnosed first at third trimester (gestational age > 28 weeks). There were 36 cases (62%) had active termination of pregnancy. Thirty eight percent (22 cases) were born at 37-42 weeks and majority were born section caesaria. The three highest proportion of organ systems involved in fetal congenital anomalies were those of abdomen (22 cases; 37,9%); head (20 cases; 34,5%); thorax and muskuloskeletal (each 12 cases; 20,7%). Conclusion: The incidence of congenital fetal anomaly in dr. Soetomo Hospital at 2017 was 4,3%. Omphalocele and CTEV were two most common types of congenital fetal anomaly found. Most cases of congenital fetal anomalies have a poor prognosis, 67% cases born died. Further research about  risk factors and comprehensive database are needed on cases of congenital anomaly to establish appropriate prevention and management.
Role Of Tea Tree Oil as A Skin Antimicrobial : A Literature Study
Authors: Ardiana Dian
Published: August 2021

Background: Skin disease due to microorganism infection are still widely found in community. The infections can be caused by bacteria, viruses, fungi, and parasite. Tea tree oil often used as a herbal medicine in the treatment of skin diseases due to microorganisms. This literature study is conducted to review the role of tea tree oil as an antimicrobial in skin infections.
Method: Fifteen indexed journals published from 2015 to 2020 about tea tree oil and skin infections, were included. From 15 journals, 9 journals discuss antibacterial activity of tea tree oil, 2 journals discuss antiviral activity, 9 journals discuss antifungal activity, and 1 journal discusses antiparasitic activity. All journals state that tea tree oil has an antimicrobial effect on microorganisms that cause skin infections.
Result: From 9 journals, it was found that A. baumanni, P. aeruginosa, and C. acnes were the most sensitive bacteria to tea tree oil in terms of MIC and S. epidermidis was the most sensitive bacteria, seen from their inhibition zone. Eight journals state variations with significant differences in the activity of tea tree oil as an anti-fungal. Tea tree oil has stronger antibacterial activity than antifungal activity. It also has antiviral activity against HSV and antiparasitic on S. scabiei.
Conclusion: The conclusion of this study is that tea tree oil has antimicrobial activity against microorganisms that cause skin disease, including bacteria, viruses, fungi, and parasite.
Isolation and molecular detection of avian mycoplasmosis in selected areas of Mymensingh district in Bangladesh
Authors: Basak Parinita , Banowary Banya , Arju Safeth , Hossain Mohammad Zakir
Published: August 2021

Avian mycoplasmosis caused by several species of Mycoplasma including Mycoplasma gallisepticum, M synoviae, M. meleagridis and M. iowae. Among these Mycoplasma gallisepticum is the most important poultry pathogen in Bangladesh. For effective control of Mycoplasmosis, proper early diagnosis is the corner stone. The research work was designed, a total of 20 samples, lung exudates, swabs from trachea and air sacs were collected from dead birds of different poultry farms in Mymensingh district during October-December, 2007. Samples were collected in 10% buffered formalin for histopathological study. Swabs were collected in mycoplasma broth supplemented with supplement-G. Additionally Kanamycin solution was added to prevent the growth of gram–Ve bacteria and then the organisms were transferred into mycoplasma agar for isolation. Histopathological studies were conducted using routine procedure in Hematoxylin and Eosin stain. Isolated Mycoplasma were subjected to DNA extraction, Nested PCR was done using a commercial PCR kit. The histopathological study revealed the presence of mycoplasmal related tissue changes, such as severe congestion and infiltration of mononuclear cells in different organs. The extracted DNA accumulated at the upper position of DNA ladder as band without any smear formation. The DNA from avian mycoplasmas was amplified and gave amplified product of 975 bp by outer primer and 395 bp by inner primer which was much smaller than the expected size. In this study, preliminary results from field samples suggest that culture using mycoplasma agar and broth supplement with Supplement-G and Kanamycin solution could be useful for the isolation of pathogenic avian mycoplasmas.
Asian J. Med. Biol. Res. 2021, 7 (2), 182-190
Two Key Ocean Governance Challenges for Sao Tome and Principe
Authors: Becker-Weinberg Vasco
Published: August 2021

Living resources directly support the livelihood of coastal communities in Sao Tome e Principe, while oil and gas reserves are needed to improve economic growth. Yet these resources are widely coveted, resulting in illegal, unreported and unregulated fishing, as well as illegal oil bunkering and theft of crude oil.

STP has settled its maritime boundaries with Equatorial Guinea and Gabon, but not with Nigeria. Instead, the two countries agreed on a joint development regime in the disputed maritime area, albeit unsuccessfully.

This article examines two key challenges currently facing STP: unblocking the STP-Nigeria joint development agreement and addressing IUUF.
EU Directive Prohibiting Gender-Based Insurance Rating: Would a South African Court Follow Suit?
Authors: Wagener Anthea Natalie
Published: August 2021

The decision of the European Court of Justice in Association belge des Consommateurs Test-Achats ASBL, Yann van Vugt, Charles Basselier v. Conseil des ministres, Judgment of the Court of Justice (Grand Chamber) of 1 March 2011 Case (C-236/09) sparked international interest and concern as it prohibited the use of gender as a rating variable in the access to and the supply of goods and services. With specific reference to motor-vehicle insurance, gender is widely used to differentiate for purposes of accurate risk classification. South African motor-vehicle insurers use, inter alia, gender as a rating variable to classify risks into certain classes and to determine insurance premiums. A South African court is still yet to decide whether the use of gender as a motor-vehicle insurance rating variable amounts to unfair discrimination or not. In light of South Africa's history of discrimination, case law and equality legislation reflect a deep commitment to substantive equality. This article explores, taking into account a South African court's approach to equality, whether the outcome may be similar to the decision of the European Court of Justice or not.
Es el Tipo de Sangre un Factor de Riesgo para el Cáncer Gástrico?
Authors: Chauca Abad Valeria Estefanía , Baculima Tenesaca José Mauricio
Published: August 2021

Introducción: Existen estudios que asocian a los grupos sanguíneos con el desarrollo de cáncer gástrico, estableciendo una relación entre los individuos con grupo sanguíneo A y la predisposición a esta neoplasia, sin embargo estos reportes podrían estar sesgados por la prevalencia poblacional del tipo sanguíneo de la región. El objetivo de este estudio es establecer la relación predicha en una zona de alta prevalencia de tipo sanguíneo O.

Métodos: Este estudio observacional, analítico fue llevado a cabo en pacientes que se realizaron biopsia de estómago vía endoscópica atendidos en el Instituto de Cáncer SOLCA Cuenca en el período 2013 – 2018; el muestreo es no probabilístico de todos los casos posibles. Para el análisis se conforma el grupo 1 (G1) con pacientes con Biopsia Positiva para Cáncer Gástrico, el grupo 2 con pacientes con Biopsia negativa para Cáncer Gástrico. Se realiza análisis de asociación con Razón de Prevalencia (RP).

Resultados: Fueron 433 casos de cáncer gástrico  en G1y 2606 casos negativos para Cáncer Gástrico en G2. La prevalencia del tipo de sangre “O” en G1 fue 328/433 casos (75.75%) Vs. 1946/2606 casos (74.67%); la prevalencia del tipo de sangre “A” en G1 fue 71/433 casos (16.4%) Vs 485/2606 casos (18.61%) en G2; RP=0.875 (IC95% 0.69 -1.11), P=0.27.

Conclusiones: No se demostró asociación entre el tipo de sangre y la presencia de Cáncer Gástrico en el presente reporte.
Linfomas de estirpe B: bases para su entendimiento
Authors: Villa Cárdenas Esteban Homero , Cárdenas Valdez Priscila Belén , Valdez Cárdenas Mónica Mercedes , Campoverde Merchán EDITOR: Dr. Felipe Xavier
Published: August 2021

Propósito de la revisión: el objetivo de la revisión es delinear la fisiopatología de los linfomas de estirpe B. Buscamos  reportes en donde se incluye la descripción del origen de los Linfomas B para una mejor comprensión de esta patología, a la luz de los avances en las diferentes áreas.

Recientes hallazgos: El Grupo Euroflow ha publicado una lista de paneles de Expresión de Antígenos de Superficie en Linfoma no Hodgkin, cuya lista se presenta en este artículo.

Extracto: Las neoplasias hematológicas han tenido grandes avances en los últimos años en varios campos, evolucionando desde la identificación citológica, pasando por su caracterización inmunofenotípica por medio de la Citometría de Flujo e Inmunohistoquímica y llegando a la caracterización molecular, iniciando por Técnicas de Cariotipo Convencional, continuando por técnicas de Inmunohibridación in situ  y actualmente con la identificación molecular por medio de la Secuenciación de Nueva Generación. Esta es la razón por la que los sistemas de estadificación han ido evolucionando también, siendo el que está al momento en vigencia el propuesto por la Organización Mundial de la Salud en el año 2016. Los linfomas constituyen un grupo heterogéneo de neoplasias hematológicas con un amplio espectro de presentación clínica, cuyo origen se encuentra en los precursores de linfoides y que afectan a los diversos órganos linfoides. De estos, los linfomas de la línea B son los más comunes, motivo de esta revisión.
Media Pocket Book dan Pemberian Tablet Fe dalam Menurunkan Anemia pada Ibu Hamil di Puskesmas Lorulun
Authors: Wahyunita Vina Dwi , Sari Marlynda Happy Nurmalita
Published: August 2021

Studi pendahuluan di Puskesmas Lorulun angka kejadian anemia masih cukup tinggi 77,7% dari 27 ibu hamil. Hal ini terjadi karena pengetahuan ibu hamil yang kurang mengenai anemia sehingga banyak ibu hamil yang tidak mengkonsumsi tablet Fe secara teratur. Tujuan kegiatan ini adalah untuk memberikan pendidikan kesehatan tentang anemia di Puskesmas Lorulun dengan media Pocketbook, screening Hb dan pemberian tablet Fe sehingga dapat meningkatkan pengetahuan ibu hamil dan mencegah anemia yang akhirnya dapat menurunkan kejadian anemia ibu hamil. Metode pengabdian dilakukan dengan pendidikan kesehatan, pemberian tablet Fe dan screening Hb. Pendidikan kesehatan yang diberikan terkait dengan anemia kehamilan seperti pengertian, penyebab, tanda gejala, akibat, pencegahan anemia dalam kehamilan, dan kebutuhan zat besi pada kehamilan. Hasil dan luaran yang didapatkan adalah pengetahuan ibu hamil tentang anemia di Puskesmas Lorulun yaitu dari 26 ibu hamil yang semula hasil pretest pengetahuan yang cukup 15,4% dan pengetahuan kurang 84,6% saat posttest mengalami peningkatan yaitu pengetahuan baik 73,1% dan pengetahuan cukup 26,9%. Diharapkan Kader dan bidan puskesmas membekali ibu hamil lainnya dengan pocket book dan modul pencegahan anemia dalam kehamilan dengan keterlibatan Puskesmas dalam menjalankan program antenatal care.
The COMPARE Database: A Public Resource for Allergen Identification, Adapted for Continuous Improvement
Authors: van Ree Ronald , Sapiter Ballerda Dexter , Berin M. Cecilia , Beuf Laurent , Chang Alexander , Gadermaier Gabriele , Guevera Paul A. , Hoffmann-Sommergruber Karin , Islamovic Emir , Koski Liisa , Kough John , Ladics Gregory S. , McClain Scott , McKillop Kyle A. , Mitchell-Ryan Shermaine , Narrod Clare A. , Pereira Mouriès Lucilia , Pettit Syril , Poulsen Lars K. , Silvanovich Andre , Song Ping , Teuber Suzanne S. , Bowman Christal
Published: August 2021

Motivation: The availability of databases identifying allergenic proteins via a transparent and consensus-based scientific approach is of prime importance to support the safety review of genetically-modified foods and feeds, and public safety in general. Over recent years, screening for potential new allergens sequences has become more complex due to the exponential increase of genomic sequence information. To address these challenges, an international collaborative scientific group coordinated by the Health and Environmental Sciences Institute (HESI), was tasked to develop a contemporary, adaptable, high-throughput process to build the COMprehensive Protein Allergen REsource (COMPARE) database, a publicly accessible allergen sequence data resource along with bioinformatics analytical tools following guidelines of FAO/WHO and CODEX Alimentarius Commission.

Results: The COMPARE process is novel in that it involves the identification of candidate sequences via automated keyword-based sorting algorithm and manual curation of the annotated sequence entries retrieved from public protein sequence databases on a yearly basis; its process is meant for continuous improvement, with updates being transparently documented with each version; as a complementary approach, a yearly key-word based search of literature databases is added to identify new allergen sequences that were not (yet) submitted to protein databases; in addition, comments from the independent peer-review panel are posted on the website to increase transparency of decision making; finally, sequence comparison capabilities associated with the COMPARE database was developed to evaluate the potential allergenicity of proteins, based on internationally recognized guidelines, FAO/WHO and CODEX Alimentarius Commission
A Comprehensive Genomic Analysis Constructs miRNA–mRNA Interaction Network in Hepatoblastoma
Authors: Chen Tong , Tian Linlin , Chen Jianglong , Zhao Xiuhao , Zhou Jing , Guo Ting , Sheng Qingfeng , Zhu Linlin , Liu Jiangbin , Lv Zhibao
Published: August 2021

Hepatoblastoma (HB) is a rare disease but nevertheless the most common hepatic tumor in the pediatric population. For patients with advanced HB, the prognosis is dismal and there are limited therapeutic options. Multiple microRNAs (miRNAs) were reported to be involved in HB development, but the miRNA–mRNA interaction network in HB remains elusive. Through a comparison between HB and normal liver samples in the GSE131329 dataset, we detected 580 upregulated differentially expressed mRNAs (DE-mRNAs) and 790 downregulated DE-mRNAs. As for the GSE153089 dataset, the first cluster of differentially expressed miRNAs (DE-miRNAs) were detected between fetal-type tumor and normal liver groups, while the second cluster of DE-miRNAs were detected between embryonal-type tumor and normal liver groups. Through the intersection of these two clusters of DE-miRNAs, 33 upregulated hub miRNAs, and 12 downregulated hub miRNAs were obtained. Based on the respective hub miRNAs, the upstream transcription factors (TFs) were detected via TransmiR v2.0, while the downstream target genes were predicted via miRNet database. The intersection of target genes of respective hub miRNAs and corresponding DE-mRNAs contributed to 250 downregulated candidate genes and 202 upregulated candidate genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses demonstrated the upregulated candidate genes mainly enriched in the terms and pathways relating to the cell cycle. We constructed protein–protein interaction (PPI) network, and obtained 211 node pairs for the downregulated candidate genes and 157 node pairs for the upregulated candidate genes. Cytoscape software was applied for visualizing the PPI network and respective top 10 hub genes were identified using CytoHubba. The expression values of hub genes in the PPI network were subsequently validated through Oncopression database followed by quantitative real-time polymerase chain reaction (qRT-PCR) in HB and matched normal liver tissues, resulting in six significant downregulated genes and seven significant upregulated genes. The miRNA–mRNA interaction network was finally constructed. In conclusion, we uncover various miRNAs, TFs, and hub genes as potential regulators in HB pathogenesis. Additionally, the miRNA–mRNA interaction network, PPI modules, and pathways may provide potential biomarkers for future HB theranostics.
Pathogenic Variants in ACTRT1 Cause Acephalic Spermatozoa Syndrome
Authors: Sha Yanwei , Liu Wensheng , Li Lin , Serafimovski Mario , Isachenko Vladimir , Li Youzhu , Chen Jing , Zhao Bangrong , Wang Yifeng , Wei Xiaoli
Published: August 2021

Acephalic spermatozoa syndrome is a rare type of teratozoospermia, but its pathogenesis is largely unknown. Here, we performed whole-exome sequencing for 34 patients with acephalic spermatozoa syndrome and identified pathogenic variants in the X-linked gene, ACTRT1, in two patients. Sanger sequencing confirmed the pathogenic variants of ACTRT1 in the patients. Both pathogenic variants of ACTRT1 were highly conserved, and in silico analysis revealed that they were deleterious and rare. Actrt1-knockout mice exhibited a similar acephalic spermatozoa phenotype. Therefore, we speculated that mutations in ACTRT1 account for acephalic spermatozoa syndrome. Moreover, the patients in this study conceived their children through artificial insemination. This study provides further insights for clinicians and researchers regarding the genetic etiology and therapeutic strategies for acephalic spermatozoa patients with pathogenic variants in ACTRT1.
Development of the Pre-gnathal Segments in the Milkweed Bug Oncopeltus fasciatus Suggests They Are Not Serial Homologs of Trunk Segments
Authors: Lev Oren , Chipman Ariel D.
Published: August 2021

The three anterior-most segments in arthropods contain the ganglia that make up the arthropod brain. These segments, the pre-gnathal segments (PGS), are known to exhibit many developmental differences to other segments, believed to reflect their divergent morphology. We have analyzed the expression and function of the genes involved in the conserved segment-polarity network, including genes from the Wnt and Hedgehog pathways, in the PGS, compared with the trunk segments, in the hemimetabolous insectOncopeltus fasciatus. Gene function was tested by manipulating expression through RNA interference against components of the two pathways. We show that there are fundamental differences in the expression patterns of the segment polarity genes, in the timing of their expression and in the interactions among them in the process of pre-gnathal segment generation, relative to all other segments. We argue that given these differences, the PGS should not be considered serially homologous to trunk segments. This realization raises important questions about the differing evolutionary ancestry of different regions of the arthropod head.
Choline Kinase Alpha Is a Novel Transcriptional Target of the Brg1 in Hepatocyte: Implication in Liver Regeneration
Authors: Kong Ming , Dong Wenhui , Xu Huihui , Fan Zhiwen , Miao Xiulian , Guo Yan , Li Chengping , Ye Qing , Wang Yutong , Xu Yong
Published: August 2021

Liver regeneration is a key compensatory process in response to liver injury serving to contain damages and to rescue liver functions. Hepatocytes, having temporarily exited the cell cycle after embryogenesis, resume proliferation to regenerate the injured liver parenchyma. In the present study we investigated the transcriptional regulation of choline kinase alpha (Chka) in hepatocytes in the context of liver regeneration. We report that Chka expression was significantly up-regulated in the regenerating livers in the partial hepatectomy (PHx) model and the acetaminophen (APAP) injection model. In addition, treatment with hepatocyte growth factor (HGF), a strong pro-proliferative cue, stimulated Chka expression in primary hepatocytes. Chka depletion attenuated HGF-induced proliferation of hepatocytes as evidenced by quantitative PCR and Western blotting measurements of pro-proliferative genes as well as EdU incorporation into replicating DNA. Of interest, deletion of Brahma-related gene 1 (Brg1), a chromatin remodeling protein, attenuated Chka induction in the regenerating livers in mice and in cultured hepatocytes. Further analysis revealed that Brg1 interacted with hypoxia-inducible factor 1 alpha (HIF-1α) to directly bind to the Chka promoter and activate Chka transcription. Finally, examination of human acute liver failure (ALF) specimens identified a positive correlation between Chka expression and Brg1 expression. In conclusion, our data suggest that Brg1-dependent trans-activation of Chka expression may contribute to liver regeneration.
Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma
Authors: Wang Yumin , Peng Zhouying , Wang Yaxuan , Yang Yi , Fan Ruohao , Gao Kelei , Zhang Hua , Xie Zhihai , Jiang Weihong
Published: August 2021

Nasopharyngeal carcinoma is a malignant tumor that is highly prevalent in southern China and the Southeast Asian belt. Recent studies have shown that the T cells play important regulatory roles in tumorigenesis and progression. We test TIL cell of recurrent nasopharyngeal carcinoma and primary nasopharyngeal carcinoma cell. We found that T cell change in recurrent nasopharyngeal carcinoma and primary nasopharyngeal carcinoma cell. Based on GEO database, we selected differently expressed circRNAs in nasopharyngeal carcinoma tissues. qRTPCR show that some circRNAs also highly expressed in TIL cells. In conclusion, immune microenvironment changed in recurrent nasopharyngeal carcinoma. There is involvement of circular RNAs in this progress, with should be researched further.
Genetic Determinants of Increased Body Mass Index Partially Mediate the Effect of Elevated Birth Weight on the Increased Risk of Atrial Fibrillation
Authors: Chen Songzan , Xu Tian , Yang Fangkun , Wang Yao , Zhang Kaijie , Fu Guosheng , Zhang Wenbin
Published: August 2021

Background: Although several observational studies have shown an association between birth weight (BW) and atrial fibrillation (AF), controversy remains. In this study, we aimed to explore the role of elevated BW on the etiology of AF.

Methods: A two-sample Mendelian randomization (MR) study was designed to infer the causality. The genetic data on the associations of single-nucleotide polymorphisms (SNPs) with BW and AF were separately obtained from two large-scale genome-wide association studies with up to 321,223 and 1,030,836 individuals, respectively. SNPs were identified at a genome-wide significant level (p <5 × 10−8). The inverse variance-weighted (IVW) method was employed to obtain causal estimates as our primary analysis. Sensitivity analyses with various statistical methods were applied to evaluate the robustness of the results, and multivariable MR analysis was conducted to determine whether this association was mediated by the body mass index (BMI).

Results: In total, 144 SNPs were identified as the genetic instrumental variables. MR analysis revealed a causal effect of elevated BW on AF (OR = 1.27, 95% CI = 1.14–1.40, p = 5.70 × 10−6). All the results in sensitivity analyses were consistent with the primary result. The effect of BW on AF was attenuated when adjusted for BMI (OR = 1.16, 95% CI = 1.01–1.33, p = 0.04).

Conclusions: This study indicated that elevated BW was significantly associated with increased lifelong risk of AF, which may be partially mediated by BMI.
The Major Driving Factors of Carbon Emissions in China and Their Relative Importance: An Application of the LASSO Model
Authors: Shum Wai Yan , Ma Ning , Lin Xiaomei , Han Tingting
Published: August 2021

China is one of the biggest energy consumers and carbon emitters in the world. Understanding the factors affecting carbon emissions is critical for policymakers to control the rising trend of carbon emissions. This paper investigates the relative importance of carbon emissions drivers in China. Literature review has been carried out to determine a set of predominant independent variables; the LASSO model is then introduced to rank the relative importance among the set of independent variables. The results find that 1) carbon emissions were mainly driven by economic growth and energy consumption followed by population size and industrialization; and 2) income growth slowed down carbon emissions during the studied period, but it is the least significant factor among the other factors. The ranking allows policy makers to focus on the most critical contributors to carbon emissions and gives policymakers more flexibility in determining policy interventions.
Identification of Eggs and Spawning Zones of Hairtail Fishes Trichiurus (Pisces: Trichiuridae) in Northern South China Sea, Using DNA Barcoding
Authors: Hou Gang , Xu Youwei , Chen Zuozhi , Zhang Kui , Huang Wangsu , Wang Jinrun , Zhou Jinlong
Published: August 2021

Commercially important hairtails, Trichiurus spp., are widely distributed throughout China’s marine waters. Because eggs of these species are difficult to identify and the taxonomy of the group has recently been resolved, their spawning grounds in the northern South China Sea (SCS) are not well known. We identified three Trichiurus species (T. japonicus, T. nanhaiensis, and T. brevis) using DNA barcodes in spring and late summer–autumn ichthyoplankton surveys of 2019 in the northern SCS. Egg distributions reveal that the spawning grounds of T. japonicus and T. nanhaiensis occur mainly from the central and southern Beibu Gulf, along Hainan Island, to the waters off the Pearl River Estuary, and that egg densities are higher in spring than in late summer-autumn. Spawning of T. japonicus commonly occurs along the continental shelf, T. nanhaiensis along the continental shelf to slope (over seabed depths of 42–380 m), and T. brevis mainly in shallow water. Considering the salinity and temperature data, we found that the eggs of Trichiurus were associated with specific water masses. In spring, eggs of T. japonicus and T. nanhaiensis occurred at central and southern Beibu Gulf water mass (CSBGWM) and South China Sea surface water mass (SCSWM). While in late summer-autumn, eggs of T. japonicus and T. nanhaiensis mainly occurred in the waters of SCSWM. Our findings reveal that the occurrence of Trichiurus eggs and their spatial and temporal distribution are determined by hydrological conditions.
Regular, Intense Exercise Training as a Healthy Aging Lifestyle Strategy: Preventing DNA Damage, Telomere Shortening and Adverse DNA Methylation Changes Over a Lifetime
Authors: Sellami Maha , Bragazzi Nicola , Prince Mohammad Shoaib , Denham Joshua , Elrayess Mohamed
Published: August 2021

Exercise training is one of the few therapeutic interventions that improves health span by delaying the onset of age-related diseases and preventing early death. The length of telomeres, the 5′-TTAGGGn-3′ tandem repeats at the ends of mammalian chromosomes, is one of the main indicators of biological age. Telomeres undergo shortening with each cellular division. This subsequently leads to alterations in the expression of several genes that encode vital proteins with critical functions in many tissues throughout the body, and ultimately impacts cardiovascular, immune and muscle physiology. The sub-telomeric DNA is comprised of heavily methylated, heterochromatin. Methylation and histone acetylation are two of the most well-studied examples of the epigenetic modifications that occur on histone proteins. DNA methylation is the type of epigenetic modification that alters gene expression without modifying gene sequence. Although diet, genetic predisposition and a healthy lifestyle seem to alter DNA methylation and telomere length (TL), recent evidence suggests that training status or physical fitness are some of the major factors that control DNA structural modifications. In fact, TL is positively associated with cardiorespiratory fitness, physical activity level (sedentary, active, moderately trained, or elite) and training intensity, but is shorter in over-trained athletes. Similarly, somatic cells are vulnerable to exercise-induced epigenetic modification, including DNA methylation. Exercise-training load, however, depends on intensity and volume (duration and frequency). Training load-dependent responses in genomic profiles could underpin the discordant physiological and physical responses to exercise. In the current review, we will discuss the role of various forms of exercise training in the regulation of DNA damage, TL and DNA methylation status in humans, to provide an update on the influence exercise training has on biological aging.