bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH MUTASI, KOMPENSASI TERHADAP KINERJA DENGAN KEPUASAN KERJA SEBAGAI VARIABEL INTERVENING (Studi Pada Perangkat Desa di Kecamatan Klirong Kabupaten Kebumen)
Authors: Parmin Parmin
Published: February 2019

Penelitian ini bertujuan untuk menganalisis pengaruh mutasi, kompensasi, dan kepuasan kerja terhadap kinerja karyawan perangkat desa di Kecamatan Klirong Kabupaten Kebumen. Penelitian ini dilakukan menggunakan bantuan alat analisis program SPSS Versi 22.0. Populasi dalam penelitian ini perangkat desa di Kecamatan Klirong menggunakan metode probability samping sebanyak 72 orang. Teknik pengambilan data dalam penelitian ini menggunakan kuisoner. Penelitian ini menggunakan metode analisis deskriptif dan statistika. Analisis statistika meliputi uji validitas, uji reliabilitas, uji multikolinieritas, uji heterokedastisitas, uji normalitas, uji t, koefisien determinasi, analisis korelasi dan analisis jalur.

Hasil penelitian menunjukkan bahwa mutasi, kompensasi berpengaruh signifikan terhadap kepuasan kerja, mutasi tidak berpengaruh terhadap kinerja, kompensasi berpengaruh terhadap kinerja dan kepuasan kerja berpengaruh terhadap kinerja perangkat desa. Hasil Koefisien determinasi substruktural I sebesar 37,1% menunjukkan bahwa adanya pengaruh hubungan yang berarti antara mutasi dan kompensasi terhadap kepuasan kerja perangkat desa dan sisanya dipengaruhi oleh variabel lain. Hasil koefisien determinasi substruktural II sebesar 46,3% menunjukkan besarnya pengaruh mutasi, kompensasi dan kepuasan kerja terhadap kinerja perangkat desa dan sisanya dipengaruhi oleh variabel lain.
IMPLEMENTASI GAME THEORY DALAM PENENTUAN STRATEGI BERSAING PADA PRODUK SMARTPHONE
Authors: Ma'rifah Diana
Published: February 2019

AbstractThe purpose of this study is to analyze competitive strategy of smartphone company. Questionnaires were distributed to 100 students of STIE Putra Bangsa Kebumen. The aims of the questionnaires were to collect the data of students smartphone brand and the reason why they choose it. The data processing found that Xiaomi and Samsung are the most smartphone brands used by students. To determine the optimal strategy for both companies is analyzed using game theory. The results of this study are Xiaomi using price strategy and Samsung using quality product strategy.Keywords: smarthphone, game theory, competitive strategy.
PENGARUH ROTASI KERJA TERHADAP KEPUASAN KERJA DALAM MEMPENGARUHI KINERJA TENAGA KEPENDIDIKAN
Authors: Warsi Diah Aryanti Sapto
Published: February 2019

The most important resources of an organization is human resouces, those giving all energy, Tlent, creativity, and effort. It is difficult for an organization to pursue its aim without having capable human reresources. Job rotation and satisfaction are parts of quality human resources management to enhance staff performance. Rotation can inprove knowledge, capability, and minimize burmout. Job satisfaction can enhance job performance.

The Purpose of this study is to investigate wheter rotation influences job satisfaction and permormance job sastifaction influences performance of 93 staffs using partial least square analysis. This study shows that rotation has asignificanly positive influences performances and rotation. Rotation is an effective way to enhance capability and knowledge, and minimize burnout, but it should consider the competency-based placement.

Keyword : job rotation, job satisfaction, staff performance.
A PROSPECTIVE STUDY OF CRANIAL ORTHOTIC TREATMENT OF INFANTS WITH ISOLATED DEFORMATIONAL BRACHYCEPHALY
Authors: Kelly Kevin M , Joganic Edward , Beals Stephen P , Riggs Jeff A , McGuire Mary Kay , Littlefield Timothy R
Published: February 2019

OBJECTIVES

The study objectives were to prospectively evaluate treatment results of infants presenting with isolated deformational brachycephaly following use of a cranial orthosis, and to investigate the role of entrance age on efficacy of treatment.

Abstract PDF  Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32024/24441

How to cite: Kelly K.M, Joganic E, Beals S.P, Riggs J.A, McGuire M.K, Littlefield T.R. A PROSPECTIVE STUDY OF CRANIAL ORTHOTIC TREATMENT OF INFANTS WITH ISOLATED DEFORMATIONAL BRACHYCEPHALY. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, ORAL PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32024                                                                           

Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee. 

http://www.aopanet.org/
EVALUATION OF LOCALIZED PAIN IN THE TRANSTIBIAL RESIDUAL LIMB
Authors: Ghoseiri Kamiar , Rastkhadiv Mohammad Yusuf , Allami Mostafa
Published: February 2019

PURPOSE

The socket is the main component of a prosthesis which surrounds the residual limb and transfers loads and motions between the residual limb and prosthesis. A misfit socket may lead to excessive stresses on the residual limb, pistoning of the prosthesis during walking, patient discomfort, pain, and skin damage. The quality of socket-skin interface directly affects quality of life, prosthesis use, and satisfaction from prosthesis in amputees. Pain is a devastating condition that prohibits prosthesis use1-4. The present study aimed to evaluate pain threshold and tolerance of the transtibial residual limb to improve its socket design and fit.  

Abstract PDF  Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32028/24445

How to cite: Ghoseiri K, Rastkhadiv M.Y, Allami M. EVALUATION OF LOCALIZED PAIN IN THE TRANSTIBIAL RESIDUAL LIMB. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, ORAL PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32028                                                                         

Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee. 

http://www.aopanet.org/
AN INNOVATIVE FOOT MODULE WITH EASILY ACCESSIBLE FRONTAL PLANE ADAPTATION ENHANCES THE LOCOMOTION ON UNEVEN GROUND
Authors: Altenburg Björn , Ernst Michael , Schmalz Thomas
Published: February 2019

INTRODUCTION

Real-life outdoor walking of amputees is challenged by uneven ground. Uneven ground requires either a component adaptation in the sagittal plane or in frontal plane or both. The lack of adaptability of prosthetic components requires compensational movement strategies by the user. Common energy storing and returning (ESR) feet have some basic flexibility through the carbon structure allowing for some limited adaptation in both planes. For the frontal plane the split toe feature adds some functionality. However, even with split toe the ROM is clearly limited and needs high force impact for minor adaptations. Now there is a novel foot module allowing for 10° inversion/eversion through a dedicated joint. This study investigates the hypothesis that such a foot module with easily accessible frontal plane adaptation enhances the locomotion on uneven ground.

Abstract PDF  Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32029/24446

How to cite: Altenburg B, Ernst M, Schmalz T. AN INNOVATIVE FOOT MODULE WITH EASILY ACCESSIBLE FRONTAL PLANE ADAPTATION ENHANCES THE LOCOMOTION ON UNEVEN GROUND. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, ORAL PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018.  DOI: https://doi.org/10.33137/cpoj.v1i2.32029

Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee. 

http://www.aopanet.org/
PERFORMANCE OF AN ACTIVITY MONITOR INTEGRATED INTO A MICROPROCESSOR KNEE
Authors: Sykes Andy , Stech Nadine , Laszczak Piotr , McGrath Michael , Kercher Alan , Zahedi Saeed , Moser David
Published: February 2019

INTRODUCTION

 For many years, the biomechanical evaluation of prosthetic performance has centred around gait analysis and motion capture. While this provides useful, scientific insights, everyday life is not limited to straight-line, level, steady-state walking. With advancements in portable sensor technology in the last two decades, long-term activity monitoring (AM) has become a more feasible and reliable prospect for accurately representing the real-world walking behaviour of patients. Modern microprocessor knees (MPKs) have begun to have this functionality built into the devices themselves, without the necessity for additional, external hardware.

Abstract PDF  Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32031/24448

How to cite: Sykes A, Stech N, Laszczak P, McGrath M, Kercher A, Zahedi S, Moser D. PERFORMANCE OF AN ACTIVITY MONITOR INTEGRATED INTO A MICROPROCESSOR KNEE. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, ORAL PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32031            

Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee. 

http://www.aopanet.org/
BACK PAIN AND OSTEOARTHRITIS AS SECONDARY DISABILITIES OF LOWER LIMB AMPUTATION
Authors: Pröbsting Eva , Kannenberg Andreas , Blumentritt Siegmar
Published: February 2019

INTRODUCTION

Long-term damages after lower extremity amputation have previously been analysed in three systematic reviews 5–7 showing that amputees have a higher risk for developing knee and hip osteoarthritis on the sound side. The altered gait pattern appears to increase the load on the sound side.1–3 This paper analysed the extent to which the above described assumption is supported by the scientific literature with specific focus on the risk of developing back pain and osteoarthritis in amputees.

Abstract PDF  Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32034/24450

How to cite: Pröbsting E, Kannenberg A, Blumentritt S. BACK PAIN AND OSTEOARTHRITIS AS SECONDARY DISABILITIES OF LOWER LIMB AMPUTATION. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, ORAL PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32034

Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee. 

http://www.aopanet.org/
INFLUENCE OF FALLS REDUCTION ON THE COST-EFFECTIVENESS OF ADVANCED HYDRAULIC MICROPROCESSOR CONTROLLED KNEE PROTHESES IN ELDERLY PATIENTS WITH LOWER LIMB AMPUTATIONS
Authors: Krüger Henning , Hahn Andreas , Kuhlmann Alexander
Published: February 2019

INTRODUCTION

The assessment of cost-effectiveness and the use of health economical methods becomes of increasing importance when evaluating the impact of modern medical technology. The cost effectiveness of advanced hydraulic microprocessor controlled knees (MPKs) had recently by shown by RAND 1. A new generation of advanced hydraulic microprocessor controlled knee (MPK) components became available to address specifically the needs of elderly individuals The reduction of concomitant factors such as falls may significantly improve cost-effectiveness.

Abstract PDF  Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32041/24455

How to cite: Krüger H, Hahn A, Kuhlmann A. INFLUENCE OF FALLS REDUCTION ON THE COST-EFFECTIVENESS OF ADVANCED HYDRAULIC MICROPROCESSOR CONTROLLED KNEE PROTHESES IN ELDERLY PATIENTS WITH LOWER LIMB AMPUTATIONS. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, ORAL PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32041                                                                          

Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee. 

http://www.aopanet.org/
HEALTH CARE ACCESSIBILITY FOR INDIVIDUALS WITH DISABILITIES: BARRIERS AND RISK FACTORS IMPACTING CARE
Authors: Senczyszyn Abbey , Duncan J. Chad
Published: February 2019

BACKGROUND

Healthcare professionals have certain professional, legal, and ethical obligations that they must fulfill with each patient interaction. Though professional and legal obligations may vary between fields of practice, the core ethical responsibility remains the same: provide just health care1. This requires that healthcare professionals are aware of systemic and institutional factors that lead to disparity and discrimination in the provision of health services1. Disability is a complex construct that can be related to various factors related to health condition as well as social and environmental factors that influence participation. This complexity results in varying definitions; the ICF model of disability was used in this research2.

Abstract PDF  Link:https://jps.library.utoronto.ca/index.php/cpoj/article/view/32046/24460

How to cite: Senczyszyn A,  Duncan J.C.  HEALTH CARE ACCESSIBILITY FOR INDIVIDUALS WITH DISABILITIES: BARRIERS AND RISK FACTORS IMPACTING CARE. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, POSTER PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32046

Abstracts were Peer-reviewed by the American Orthotic Prosthetic Association (AOPA) 101st National Assembly Scientific Committee. 

http://www.aopanet.org/
Efficacy and safety of regorafenib versus dinutuximab with chemotherapy in Chinese children with neuroblastoma
Authors: Dong Kun , Wang Guan , Wang Zeng Liang , Wang Xueyan
Published: February 2019

The objective of the present study was to evaluate the efficacy and safety of regorafenib in comparison with dinutuximab with chemotherapy in Chinese children with advanced neuroblastoma. The patients aged less than 16 years who were histologically diagnosed with advanced neuroblastoma were enrolled and randomized to receive either regorafenib plus best supportive care or dinutuximab plus chemotherapy plus best supportive care in a 1:1 ratio. The tumor response assessment was made in accordance with modified international neuroblastoma response criteria. Adverse events were also assessed. Regorafenib showed prolonged overall survival and progression-free survival than who received dinutuximab plus chemotherapy (overall survival: median 32.3 months versus 27.2 months; hazard ratio = 0.45; 95% CI 0.11-0.13, p<0.001; progression-free survival: stratified hazard ratio = 0.48; 95% CI 0.11-0.14; p<0.01).  Moreover, the overall response rate was greater in patients treated with regorafenib as compared to dinutuximab group. Regorafenib appears efficacious and has a manageable safety profile in Chinese children with advanced neuroblastoma.
Les impacts du vieillissement de la population française sur les systèmes sanitaires et médico-sociaux : une analyse des revues académiques et professionnelles depuis la loi ASV
Authors: Hentic-Giliberto Michelle , Stephan Sylvie
Published: February 2019

La loi d’Adaptation de la Société au Vieillissement (ASV), promulguée en décembre 2015, fait de la prise en compte du vieillissement « un impératif national et une priorité de l’ensemble des politiques publiques de la nation ». Le présent article vise à nourrir l’état des lieux de la prise en compte de cette problématique, au moyen d’une étude du contenu éditorial de la littérature académique et professionnelle francophone. La recherche porte sur deux corpus , l’un extrait du portail de sciences humaines et sociales de langue française CAIRN.INFO, l’autre constitué de 330 articles issus de revues du secteur sanitaire et médico-social sur la période allant de janvier 2015 à mai 2018. Une démarche exploratoire fondée sur une analyse lexicale permet d’extraire des contenus, l’approche du vieillissement telle qu’elle est abordée dans les travaux académiques en SHS et spécifiquement en économie-gestion, et dans les revues professionnelles du secteur sanitaire et médico-social. Une étude approfondie est menée sur les trois thématiques que sont la gouvernance du système de santé, le management des structures sanitaires et médico-sociales, la silver économie. Les résultats font apparaître que si la sociologie est la discipline qui étudie de manière plus marquée l’émergence et les conséquences du vieillissement sur l’environnement et les populations (66 articles), seuls 28 articles en sciences économiques et sciences de gestion lui sont consacrés. Ces derniers identifient principalement la problématique de la gouvernance du vieillissement au niveau macro-économique ou en lien avec les situations particulières de certains pays. Seuls, quelques rares articles s’intéressent spécifiquement à la situation française et aux dimensions managériale, organisationnelle ou opérationnelle. Concernant les revues professionnelles, l’accent est mis sur le positionnement de la personne âgée au cœur du dispositif d’accompagnement, les thématiques de la dépendance et des domaines et modalités de sa prise en charge sont largement discutées. De part et d’autre la silver économie, pourtant identifiée comme un véritable levier de croissance (OMS 2 , 2016), reste mal identifiée.
Georges Bataille et la théorie de la religion
Authors: Machado Da Silva Juremir
Published: February 2019

Ce texte examine la théorie de la religion esquissée par Georges Bataille en 1948 comme une quête de communication. Il ne s’agit pas d’une exégèse de l’œuvre de cet auteur, mais plutôt d’une réflexion libre à partir des idées semées par le philosophe. On prend ici la religion comme une parole, un cri, une ouverture vers l’Autre.
Une pensée inutile
Authors: Maffesoli Michel
Published: February 2019

Dans la lignée de penseurs trop délaissés, tels Goerges Bataille, Georg Simmel, l’auteur tente de montrer comment il y a un « hédonisme du quotidien » qui sous-tend toute vie en société. Non plus une attente, une tension vers l’avenir, mais un présentéisme. On voit resurgir ce que Bataille nommait la « part maudite », cet aspect chtonien, nocturne de l’imaginaire. Le lien social devient émotionnel. Ce que l’auteur nomme « une éthique de l’esthétique ».
La part de l’autre. Georges Bataille, notre prochain
Authors: Tacussel Patrick
Published: February 2019

L’objectif de cet article est de mettre en relief la force de la pensée radicale de Georges Bataille par la mise en perspective des multiples aspects de son œuvre explorant les arcanes de la société. L’accent est mis sur une expérience intérieure conçue comme fil conducteur nous amenant à une compréhension de l’hétérogénéité du social via la transgression, l’énergie, la dépense : en somme une exploration de la vie dans toute sa puissance.
La politique d’éros comme volonté de chance
Authors: Christias Panagiotis
Published: February 2019

À partir de l’ouvrage Sur Nietzsche de Georges Bataille, l’auteur pointe la mise en jeu de la chance en tant que donnée du monde. La problématique théorique est fondée sur une « expérience intérieure » qui met en scène un sujet désirant cette existence de la chance, alors qu’elle suscite en même temps une part d’angoisse et qu’elle met également en question la raison et l’autre.
Laure. Le démon de la curiosité et ses échos
Authors: Chiore Valeria
Published: February 2019

La réflexion porte ici sur la figure de Colette Peignot, dite Laure, au centre d’un cercle englobant Nietzsche, Lautréamont, Klossowski et bien sûr Bataille, pour lequel elle fut une muse inspiratrice. Ses écrits sont une sorte de kaléidoscope dans lequel on peut percevoir la force d’écrire et celle de lire. L’attention est portée sur les textes posthumes Histoire d’une petite fille et Le sacré , afin d’en saisir les images, émotions et réflexions qui ont particulièrement irradié Georges Bataille, tant dans sa vie que dans son œuvre.
Les Trente sans gloire vues par l’œil de Bataille
Authors: Romano Onofrio
Published: February 2019

La pensée de Georges Bataille est toujours d’actualité et nous aide à interroger notre présent. L’objectif de cet article consiste à proposer une compréhension des trente sans gloire du néo-libéralisme sous l’angle de la souveraineté, de la dépense et de l’excédent d’énergie dont les effets sur le sujet contemporain sont manifestes, en inaugurant en définitive une possible construction sociale de la conscience de soi.
Des origines du capital. Bataille et Youporn
Authors: Abruzzese Alberto , Perboyer Fabienne
Published: February 2019

Nous faisons ici appel à quelques thèmes de prédilection de Georges Bataille tels que l’érotisme, le non-savoir, la dépense, afin de mieux comprendre certains phénomènes de notre actualité, en particulier Youporn. Nous mettrons ainsi en évidence la dissipation du désir et la critique des valeurs de la société moderne et interrogerons aussi bien le contenu du capitalisme que l’expansion numérique de l’existence.
A Dedicated Fracture Reduction Room: A Cost-Effective Alternative to the Operating Room
Authors: Whitlock Patrick W. , Little Kevin J. , Singleton Sandra S. , Mahmoud Mohamed , Ngamprasertwong Pornswan , McCarthy James J.
Published: February 2019

Introduction:

Charges, procedural efficiency, return to activity, and complications after closed treatment of fractures performed in an operating room (OR) versus closed reduction in a dedicated fracture reduction room (FRR) were compared.

Methods:

Patients with closed fractures of the forearm who underwent closed reduction in the year before (OR), and after implementation of the FRR, were retrospectively reviewed. Charges, American Society of Anesthesiologists class, sex, age, length of follow-up, prior reduction, fracture location/displacement, time from injury to procedure, procedural time, time to return to activity, and complications were recorded.

Results:

Eighteen patients met the inclusion criteria in the FRR group (13 men, 5 women), and 22 in the OR group (18 men, 4 women). No notable differences in age, sex, follow-up, American Society of Anesthesiologists class, fracture location/displacement, incidence of prior reduction, or time to return to activity were observed. Two (9.5%) complications occurred in the FRR group versus 7 (32%) in the OR group, P > 0.05. No anesthesia complications were present. Patients treated in the FRR incurred charges of $5,299 ± $1,289 versus $10,455 ± $2,290 in the OR, P < 0.001. Total time of visit in the FRR was ∼30% less than the OR, P < 0.001. No notable delay in treatment was observed.

Discussion:

In the era of finite resources and value-based care, implementation of a FRR resulted in safe, cost-effective, and increased procedural efficiency.
Recurrent Hemarthrosis After Total Knee Arthroplasty: Evaluation and Treatment
Authors: Ravi Bheeshma , Hosack Luke , Backstein David , Spangehl Mark
Published: February 2019

Recurrent hemarthrosis (RH) is a rare complication (∼1%) after total knee arthroplasty (TKA). It is a complex and particularly frustrating problem for both patient and surgeon. Typically, patients present several months to years after their index TKA surgery with a painful and swollen joint. Although conservative management may provide temporary relief, the rate of recurrence is high. Despite extensive case series in the literature, no consensus was made on the criteria needed to establish this diagnosis, or how to best provide treatment. Several management strategies have been described for RH, including immobilization, arthroscopic versus open synovectomy, angiographic embolization, and revision arthroplasty. All of these have demonstrated variable effectiveness, with limited evidence for their use in specific situations. This review synthesizes the available literature and suggests an algorithm for the diagnosis and treatment of RH after TKA.
Simultaneous Analysis of Iodine and Bromine Species in Infant Formula using HPLC-ICP-MS
Authors: Nelson Jenny , Pacquette Lawrence , Dong Shuofei , Yamanaka Michiko
Published: February 2019

Background: A fast and sensitive method for the simultaneous analysis of iodine and bromine species in infant formula was developed using HPLC–inductively coupled plasma–MS (HPLC-ICP-MS). Method: To determine the four halogen species [iodide (I−), iodate (IO3−), bromide (Br−), and bromate (BrO3−)] in a milk-based Standard Reference Material and four commercially available infant formula products. Results: The four halogen species were baseline separated in less than 6.5 min using an anion exchange resin column and 5.0 mM NaH2PO4 / 15.0 mM Na2SO4 / 5.0 mM EDTA (pH 7.0) mobile phase. Following separation, the halogen species were detected by measuring m/z 79 for Br and m/z 127 for I using a triple quadrupole–ICP-MS. The instrument was operated in single quadrupole mode with helium cell gas. Excellent linearity (R = 0.9999 or better) was obtained for all four species with calibration standards ranging from 0 to 100 ppb. The LOD for I−, IO3−, Br−, and BrO3− were all less than 0.67 μg/kg. To test the suitability of the method for the accurate determination of low concentrations of the four species in infant formula samples, a spike recovery test was carried out at 20 and 40 μg/kg into the diluted infant formula samples. Conclusions: Total elemental determinations of iodine and bromine were also performed using the triple quadrupole–ICP-MS without HPLC.
A Cartesian Rereading of Badiou’s Political Subjectivity
Authors: Griffith James ,   DePaul University
Published: February 2019

This article traces the consequences for Badiou’s political subjectivity if his understanding of the Cartesian subject is incorrect. For Badiou, the faithful subject, political and otherwise, is formed through fidelity to the appearance of an event of truth, and the process of this fidelity creates a world. These truths are immanent to the worlds in which they appear. An obscure subject, however, is faithful to a negation, while a reactive subject denies the appearance of a truth’s event. Badiou’s subject radicalizes Lacan’s radicalization of the Cartesian subject, but for him both Descartes and Lacan consider the subject stable since they are caused by truth rather than by the event of a truth. However, immanent to Descartes’s philosophy is an unstable subject, thanks to the role of the imagination in the discovery of the cogito. Fidelity to this immanent Cartesian subject shows Lacan as an obscure subject and Badiou as reactive.
Threshold value and applicable range of nonlinear behavior detection method using second derivative of acceleration
Authors: Iyama Jun , Wakui Masaki
Published: February 2019

A previously proposed nonlinearity detection method using the second derivative “snap” of the recorded absolute acceleration requires the determination of a threshold value based on the yield strength of the target vibration system, which may not be known. Therefore, this study aims to extend this detection method by determining the mathematical relation between the snap and stiffness change and velocity of the vibration system; the results indicate that the threshold value required to detect nonlinearities can be explicitly expressed by mathematical equations. Although the accuracy of this detection method is affected by the intensity of noise and the time intervals of the acceleration records, the introduced mathematical model can both explain these effects and allow the user to decide a priori whether this method can be used to detect nonlinearities. Furthermore, the proposed mathematical model for nonlinearity detection was verified by dynamic response analysis with varying natural periods, showing that the detectable range estimated by the model agreed with the range where the accuracy of nonlinearity detection by snap increases.
ADA settlement exposes liability when providers refuse MAT patients
Authors: Enos Gary
Published: February 2019

A newly announced settlement agreement between the U.S. Department of Justice and a private group medical practice in Virginia serves as a stark reminder that discrimination against individuals with an opioid use disorder (OUD) can interfere with patient access to treatment in the mainstream medical community.
A Note on CBD: It's All in a Name
Authors: Clark H. Westley
Published: February 2019

I recently saw an article with the following title: “Medical cannabis relieves symptoms in children with autism.” On reading it, I realized that the Drug Target Review was talking about cannabidiol, otherwise known as CBD, not THC (tetrahydrocannabinol, the psychoactive ingredient in cannabis). I also realized the words cannabis and marijuana are no longer useful in talking about marijuana now that CBD has been moved to Schedule V of the Controlled Substances Act when manufactured by GW Pharmaceuticals. Still, it is common to see CBD lumped with the hundreds of other cannabinoids, especially if not produced by a Food and Drug Administration (FDA)–approved pharmaceutical company where it is still classified as Schedule I by the Drug Enforcement Administration (DEA). I think this has implications for popular understanding and clinical utility.
Substituent Position‐Controlled Stereoselectivity in Enzymatic Reduction of Diaryl‐ and Aryl(heteroaryl)methanones
Authors: Li Zhining , Wang Zexu , Wang Yuhan , Wu Xiaofan , Lu Hong , Huang Zedu , Chen Fener
Published: February 2019

We report here the discovery of a novel ketoreductase (KRED), named KmCR2, with a broad substrate spectrum on bioreduction of sterically bulky diaryl‐ and aryl(heteroaryl)methanones. The position of the substituent on aromatic rings (meta versus para or ortho) was revealed to control the stereospecificity of KmCR2. The stereoselective preparation of both enantiomers of diaryl‐ or aryl(heteroaryl)methanols using strategically engineered substrates with a traceless directing group (bromo group) showcased the potential application of this substrate‐controlled bioreduction reaction. The combined use of substrate engineering and protein engineering, was demonstrated to be a useful strategy in efficiently improving stereoselectivity or switching stereopreference of enzymatic processes.

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Confirmation of a new phenotype in an individual with a variant in the last part of exon 30 of CREBBP
Authors: Angius Andrea , Uva Paolo , Oppo Manuela , Persico Ivana , Onano Stefano , Olla Stefania , Pes Valentina , Perria Chiara , Cuccuru Gianmauro , Atzeni Rossano , Serra Gigliola , Cucca Francesco , Sotgiu Stefano , Hennekam Raoul C. , Crisponi Laura
Published: February 2019

We report here a novel de novo missense variant affecting the last amino acid of exon 30 of CREBBP [NM_004380, c.5170G>A; p.(Glu1724Lys)] in a 17‐year‐old boy presenting mild intellectual disability and dysmorphisms but not resembling the phenotype of classical Rubinstein–Taybi syndrome. The patient showed a marked overweight from early infancy on and had cortical heterotopias. Recently, 22 individuals have been reported with missense mutations in the last part of exon 30 and the beginning of exon 31 of CREBBP, showing this new phenotype. This additional case further delineates the genotype–phenotype correlations within the molecular and phenotypic spectrum of variants in CREBBP and EP300.
Substantial pain burden in frequency, intensity, interference and chronicity among children and adults with neurofibromatosis Type 1
Authors: Kongkriangkai Alanna M. , King Christopher , Martin Lisa J. , Wakefield Emily , Prada Carlos E. , Kelly‐Mancuso Geraldine , Schorry Elizabeth K.
Published: February 2019

Tumor growths, migraine headaches, and other health‐related complications reported in patients with neurofibromatosis type 1 (NF1) are often associated with pain. Thus, this study sought to describe and quantify the pain experience in children and young adults with NF1. Surveys were administered to 49 participants (28 children and 21 adults), ages 8 through 40 years. The survey included the Numeric Rating Scale 11 (NRS11) to assess pain intensity and the Patient Reported Outcomes Measurement Information System (PROMIS) to assess pain interference. A supplemental survey was created to measure pain frequency, chronicity, quality, and location. Results suggest pain is not only present in 55% of the cohort, but that it can begin at early ages. Pain was chronic in 35% of participants, with 41% reporting the use of medication to manage pain symptoms. Common sources of pain included migraine headaches and NF‐related tumors. Pain was described as having neuropathic features (i.e., burning, tingling, numbness, or itching), and was localized to the head, back, and extremities. Further, subsets of participants reported moderate‐to‐severe pain intensity, high frequency of pain, and interference of pain in daily activities. Continued investigation of the pain experience in a multisystem disorder, such as NF1, remains essential to providing guidance in the setting of complex pain management.
Synthesis of Redox‐switchable 5,15‐Dialkyl‐10,20‐diaryl‐5,15‐diazaporphyrins and Diversification of their N‐Alkyl Groups
Authors: Mutoh Mai , Sudoh Keisuke , Furukawa Ko , Minoura Mao , Nakano Haruyuki , Matano Yoshihiro
Published: February 2019

Nickel(II) and copper(II) complexes of redox‐switchable 20π, 19π, and 18π 5,15‐dialkyl‐10,20‐diaryl‐5,15‐diazaporphyrins were prepared through a metal‐templated cyclization method. Furthermore, the terminal silyloxy groups in the peripheral N‐alkyl chains were transformed into hydroxy groups by deprotection. It is worth noting that redox reactions between the 19π and 18π systems bearing hydroxy groups caused a change in the water solubility of the diazaporphyrin chromophore.
Skin nerve pathology: Biomarkers of premanifest and manifest amyloid neuropathy
Authors: Chao Chi‐Chao , Hsueh Hsueh‐Wen , Kan Hung‐Wei , Liao Chun‐Hua , Jiang Hao‐Hua , Chiang Hao , Lin Whei‐Min , Yeh Ti‐Yen , Lin Yea‐Huey , Cheng Ya‐Yin , Hsieh Sung‐Tsang
Published: February 2019

Objective

Small‐fiber sensory and autonomic symptoms are early presentations of familial amyloid polyneuropathy (FAP) with transthyretin (TTR) mutations. This study aimed to explore the potential of skin nerve pathologies as early and disease‐progression biomarkers and their relationship with skin amyloid deposits.

Methods

Skin biopsies were performed in patients and carriers to measure intraepidermal nerve fiber (IENF) density, sweat gland innervation index of structural protein gene product 9.5 (SGII[PGP9.5]) and peptidergic vasoactive intestinal peptide (SGII[VIP]), and cutaneous amyloid index. These skin pathologies were analyzed with clinical disability assessed by FAP stage score (stage 0–4) and compared to neurophysiological and psychophysical tests.

Results

There were 70 TTR‐mutant subjects (22 carriers and 48 patients), and 66 cases were TTR‐A97S. Skin nerve pathologies were distinct according to stage. In carriers, both skin denervation and peptidergic sudomotor denervation were evident: (1) IENF density was gradually reduced from stage 0 through 4, and (2) SGII(VIP) was markedly reduced from stage 1 to 2. In contrast, SGII(PGP9.5) was similar between carriers and controls, but it declined in patients from stage 2. Skin amyloids were absent in carriers and became detectable from stage 1. Cutaneous amyloid index was correlated with SGII(PGP9.5) and stage in a multivariate mixed‐effect model. When all tests were compared, only IENF density, SGII(PGP9.5), and cutaneous amyloid index were correlated with stage, and IENF density had the highest abnormal rate in carriers.

Interpretation

Biomarkers of sensory and sudomotor innervation exhibited a stage‐dependent progression pattern, with sensory nerve degeneration as the early skin nerve pathology. Ann Neurol 2019;85:560–573
The siRNAsome: A Cation‐Free and Versatile Nanostructure for siRNA and Drug Co‐delivery
Authors: Zheng Meng , Jiang Tong , Yang Wen , Zou Yan , Wu Haigang , Liu Xiuhua , Zhu Fengping , Qian Rongjun , Ling Daishun , McDonald Kerrie , Shi Jinjun , Shi Bingyang
Published: February 2019

Nanoparticles show great potential for drug delivery. However, suitable nanostructures capable of loading a range of drugs together with the co‐delivery of siRNAs, which avoid the problem of cation‐associated cytotoxicity, are lacking. Herein, we report an small interfering RNA (siRNA)‐based vesicle (siRNAsome), which consists of a hydrophilic siRNA shell, a thermal‐ and intracellular‐reduction‐sensitive hydrophobic median layer, and an empty aqueous interior that meets this need. The siRNAsome can serve as a versatile nanostructure to load drug agents with divergent chemical properties, therapeutic proteins as well as co‐delivering immobilized siRNAs without transfection agents. Importantly, the inherent thermal/reduction‐responsiveness enables controlled drug loading and release. When siRNAsomes are loaded with the hydrophilic drug doxorubicin hydrochloride and anti‐P‐glycoprotein siRNA, synergistic therapeutic activity is achieved in multidrug resistant cancer cells and a tumor model.
Oxygen Evolution Reaction over the Au/YSZ Interface at High Temperature
Authors: Song Yuefeng , Zhou Si , Dong Qiao , Li Yangsheng , Zhang Xiaomin , Ta Na , Liu Zhi , Zhao Jijun , Yang Fan , Wang Guoxiong , Bao Xinhe
Published: February 2019

The oxygen evolution reaction (OER) is a sluggish electrocatalytic reaction in solid oxide electrolysis cells (SOECs) at high temperatures (600–850 °C). Perovskite oxide has been widely investigated for catalyzing the OER; however, the formation of cation‐enriched secondary phases at the oxide/oxide interface blocks the active sites and decreases OER performance. Herein, we show that the Au/yttria‐stabilized zirconia (YSZ) interface possesses much higher OER activity than the lanthanum strontium manganite/YSZ anode. Electrochemical characterization and density functional theory calculations suggest that the Au/YSZ interface provides a favorable path for OER by triggering interfacial oxygen spillover from the YSZ to the Au surface. In situ X‐ray photoelectron spectroscopy results confirm the existence of spillover oxygen on the Au surface. This study demonstrates that the Au/YSZ interface possesses excellent catalytic activity for OER at high temperatures in SOECs.
Solid Base Bi24O31Br10(OH)δ with Active Lattice Oxygen for the Efficient Photo‐Oxidation of Primary Alcohols to Aldehydes
Authors: Dai Yitao , Ren Pengju , Li Yaru , Lv Dongdong , Shen Yanbin , Li Yongwang , Niemantsverdriet Hans , Besenbacher Flemming , Xiang Hongwei , Hao Weichang , Lock Nina , Wen Xiaodong , Lewis James P. , Su Ren
Published: February 2019

The selective oxidation of primary alcohols to aldehydes by O2 instead of stoichiometric oxidants (for example, MnVII, CrVI, and OsIV) is an important but challenging process. Most heterogeneous catalytic systems (thermal and photocatalysis) require noble metals or harsh reaction conditions. Here we show that the Bi24O31Br10(OH)δ photocatalyst is very efficient in the selective oxidation of a series of aliphatic (carbon chain from C1 to C10) and aromatic alcohols to their corresponding aldehydes/ketones under visible‐light irradiation in air at room temperature, which would be challenging for conventional thermal and light‐driven processes. High quantum efficiencies (71 % and 55 % under 410 and 450 nm irradiation) are reached in a representative reaction, the oxidation of isopropanol. We propose that the outstanding performance of the Bi24O31Br10(OH)δ photocatalyst is associated with basic surface sites and active lattice oxygen that boost the dehydrogenation step in the photo‐oxidation of alcohols.
Photoinduced Reversible Solid‐to‐Liquid Transitions for Photoswitchable Materials
Authors: Xu Wen‐Cong , Sun Shaodong , Wu Si
Published: February 2019

Heating and cooling can induce reversible solid‐to‐liquid transitions of matter. In contrast, athermal photochemical processes can induce reversible solid‐to‐liquid transitions of some newly developed azobenzene compounds. Azobenzene is photoswitchable. UV light induces trans‐to‐cis isomerization; visible light or heat induces cis‐to‐trans isomerization. Trans and cis isomers usually have different melting points (Tm) or glass transition temperatures (Tg). If Tm or Tg of an azobenzene compound in trans and cis forms are above and below room temperature, respectively, light may induce reversible solid‐to‐liquid transitions. In this Review, we introduce azobenzene compounds that exhibit photoinduced reversible solid‐to‐liquid transitions, discuss the mechanisms and design principles, and show their potential applications in healable coatings, adhesives, transfer printing, lithography, actuators, fuels, and gas separation. Finally, we discuss remaining challenges in this field.
Cetacean Skull Telescoping Brings Evolution of Cranial Sutures into Focus
Authors: Roston Rachel A. , Roth V. Louise
Published: February 2019

Many modifications to the mammalian bauplan associated with the obligate aquatic lives of cetaceans—fusiform bodies, flukes, flippers, and blowholes—are evident at a glance. But among the most strikingly unusual and divergent features of modern cetacean anatomy are the arrangements of their cranial bones: (1) bones that are situated at opposite ends of the skull in other mammals are positioned close together, their proximity resulting from (2) these bones extensively overlapping the bones that ordinarily would separate them. The term “telescoping” is commonly used to describe the odd anatomy of modern cetacean skulls, yet its usage and the particular skull features to which it refers vary widely. Placing the term in historical and biological context, this review offers an explicit definition of telescoping that includes the two criteria enumerated above. Defining telescoping in this way draws attention to many specific biological questions that are raised by the unusual anatomy of cetacean skulls; highlights the central role of sutures as the locus for changes in the sizes, shapes, mechanical properties, and connectivity of cranial bones; and emphasizes the importance of sutures in skull development and evolution. The unusual arrangements of cranial bones and sutures referred to as telescoping are not easily explained by what is known about cranial development in more conventional mammals. Discovering the evolutionary‐developmental processes that produce the extensive overlap characteristic of cetacean telescoping will give insights into both cetacean evolution and the “rules” that more generally govern mammalian skull function, development, and evolution. Anat Rec, 302:1055–1073, 2019. © 2019 Wiley Periodicals, Inc.
Chrysophanol Suppresses Hypoxia‐Induced Epithelial‐Mesenchymal Transition in Colorectal Cancer Cells
Authors: Deng Min , Xue Yong‐Ju , Xu Le‐Rong , Wang Qiang‐Wu , Wei Jun , Ke Xi‐Quan , Wang Jian‐Chao , Chen Xiao‐Dong
Published: February 2019

Colorectal cancer (CRC) is a common human malignancy, accounting for 600,000 death cases annually worldwide. Chrysophanol is a naturally occurring anthraquinone compound and exhibits anti‐neoplastic activities. This study aims to explore the biological effects of chrysophanol on CRC metastasis and the relevant underlying mechanism. Cell proliferation assay, wound scratch assay, and Transwell invasion assay were used to examine the effect of chrysophanol on proliferation, migration, and invasion of CRC cells. Hypoxia‐inducible factor‐1α (HIF‐1α) shRNA was utilized to transfect CRC cells to examine the role of HIF‐1α in chrysophanol suppression of hypoxia‐induced epithelial to mesenchymal transition (EMT). The suppression effect of chrysophanol on hypoxia‐induced EMT in vivo was also validated in xenograft tumor models. In the present study, our findings indicated that chrysophanol has the capability to suppress hypoxia‐induced EMT in CRC in vitro and in vivo, and the possible mechanism involved is the inhibition of HIF‐1α via modulating PI3k/Akt signaling pathway. Collectively, the results indicated that chrysophanol can be used as an EMT and cancer metastasis inhibitor in the treatment of CRC. Anat Rec, 302:1561–1570, 2019. © 2019 American Association for Anatomy
Modeling, simulations, and optimization of smooth muscle cell tissue engineering for the production of vascular grafts
Authors: Elsayed Yahya , Lekakou Constantina , Tomlins Paul
Published: February 2019

The paper presents a transient, continuum, two‐phase model of the tissue engineering in fibrous scaffolds, including transport equations for the flowing culture medium, nutrient and cell concentration with transverse and in‐plane diffusion and cell migration, a novel feature of local in‐plane transport across a phenomenological pore and innovative layer‐by‐layer cell filling approach. The model is successfully validated for the smooth muscle cell tissue engineering of a vascular graft using crosslinked, electrospun gelatin fiber scaffolds for both static and dynamic cell culture, the latter in a dynamic bioreactor with a rotating shaft on which the tubular scaffold is attached. Parametric studies evaluate the impact of the scaffold microstructure, cell dynamics, oxygen transport, and static or dynamic conditions on the rate and extent of cell proliferation and depth of oxygen accessibility. An optimized scaffold of 75% dry porosity is proposed that can be tissue engineered into a viable and still fully oxygenated graft of the tunica media of the coronary artery within 2 days in the dynamic bioreactor. Such scaffold also matches the mechanical properties of the tunica media of the human coronary artery and the suture retention strength of a saphenous vein, often used as a coronary artery graft.
Biosorption of lanthanum and samarium by viable and autoclaved mycelium of Botryosphaeria rhodina MAMB‐05
Authors: Giese Ellen C. , Dekker Robert F. H. , Barbosa‐Dekker Aneli M.
Published: February 2019

The ascomycetous fungus, Botryosphaeria rhodina MAMB‐05, secretes a (1→3)(1→6)‐β‐D‐glucan, and the scaled‐up production of this β‐glucan results in large amounts of mycelial biomass being produced that represent a potentially cost‐effective biosorbent for rare‐earth elements. High sorption capacities for both La(III) and Sm(III) were demonstrated for viable and autoclaved lyophilized fungal mycelium. Fourier‐transformed infra‐red absorption spectra and the point of zero charge (PZC) were similar for the viable and inactive fungal mycelia. The rare‐earth lanthanide elements (La and Sm) binding increased at initial pH values greater than 5.0, which was also observed for the PZC determination. The maximum La(III) uptake capacity was observed at lower amounts of La(III) ions in solution, decreasing from 100.0 to 25.3% when the initial lanthanide concentration increased from 15 to 100 mg/L. Lanthanide biosorption by B. rhodina MAMB‐05 mycelia followed the Langmuir model, and the affinity of biosorbent functional groups was similar for La(III) and Sm(III).
Photoactivable Elimination of Tumorigenic Human Induced Pluripotent Stem Cells by Using a Lectin–Doxorubicin Prodrug Conjugate
Authors: Dion Johann , Minoshima Fumi , Saito Sayoko , Kiyoi Kayo , Hasehira Kayo , Tateno Hiroaki
Published: February 2019

Human pluripotent stem cells (hPSCs) are attractive resources for regenerative medicine, but medical applications are hindered by their tumorigenic potential. Previously, a hPSC‐specific lectin probe, rBC2LCN, was identified through comprehensive glycome analysis by using high‐density lectin microarrays. Herein, a lectin–doxorubicin (DOX) prodrug conjugate, with controllable photolysis activation for the elimination of tumorigenic human induced pluripotent stem cells, has been developed. rBC2LCN was fused with a biotin‐binding protein, tamavidin (BC2Tama), and the fusion protein was expressed in Escherichia coli and purified by means of affinity chromatography. BC2Tama was then conjugated with doxorubicin‐photocleavable biotin (DOXPCB). The BC2Tama–DOXPCB conjugates were observed to bind to hPSCs followed by internalization. Upon exposure to ultraviolet light, DOX was released inside the cells, which allowed specific killing of the hPSCs. Thus, BC2Tama–DOXPCB should be useful for the targeted elimination of hPSCs contained in hPSC‐derived cell therapy products. This is the first report of the generation of lectin–prodrug conjugates. BC2Tama should be applicable for the targeted delivery of various types of biotinylated compounds into hPSCs.