bluuebunny/crossref_metadata_2025 huggingface dataset:
Αξιοποίηση του συστήματος διαχείρισης μάθησης LAMS για την εφαρμογή συνεργατικών δραστηριοτήτων Διαφοροποιημένης Διδασκαλίας.
Authors: Κονταξή Ιωάννα , Ρώσσιου Ελένη
Published: October 2018

Η παρούσα εργασία έχει ως σκοπό την διερεύνηση της αξιοποίησης του Συστήματος Διαχείρισης Μάθησης LAMS για την εφαρμογή συνεργατικών δραστηριοτήτων Διαφοροποιημένης Διδασκαλίας σε μαθητές ΕΠΑΛ. Με γνώμονα την ενίσχυση του παραδοσιακού τρόπου διδασκαλίας σε τάξεις μικτής ικανότητας, σχεδιάστηκαν μαθησιακές δραστηριότητες Διαφοροποιημένης Διδασκαλίας σε περιβάλλον LAMS και εκτελέστηκαν από τους μαθητές ενός Επαγγελματικού Λυκείου, στα πλαίσια του μαθήματος «Προγραμματισμός Υπολογιστών» της Γ’ τάξης ΕΠΑΛ.Για την  αξιολόγηση του βαθμού συνεργασίας των μαθητών κατά την εκτέλεση δραστηριοτήτων σε περιβάλλον LAMS, οι είκοσι εφτά (27) συμμετέχοντες μαθητές συμπλήρωσαν ερωτηματολόγιο και παραχώρησαν συνεντεύξεις. Παράλληλα μελετήθηκαν στοιχεία του περιβάλλοντος καταγραφής του LAMS που αφορούσαν το είδος και την ποσότητα των μηνυμάτων που αντάλλαξαν οι μαθητές κατά τις συνεργατικές δραστηριότητες. Κατ’ αυτό τον τρόπο, συλλέχθηκαν ποσοτικά και ποιοτικά δεδομένα, ακολουθώντας μία μικτή προσέγγιση.Η διαδικασία της αποτίμησης μας έδωσε τη δυνατότητα να αποφανθούμε υπέρ της χρήσης του LAMS για την υποστήριξη συνεργατικών δραστηριοτήτων που σχεδιάζονται βάσει των αρχών της Διαφοροποιημένης Διδασκαλίας. Οι μαθητές εκτίμησαν ιδιαιτέρως τον συνεργατικό τρόπο εργασίας στο LAMS, επιθυμώντας την επανάληψη ανάλογων δραστηριοτήτων.
Computational assessment of stomach tumor volume from multi-slice computerized tomography images in presence of type 2 cancer
Authors: Chacón Gerardo , Rodríguez Johel E. , Bermúdez Valmore , Vera Miguel , Hernández Juan Diego , Vargas Sandra , Pardo Aldo , Lameda Carlos , Madriz Delia , Bravo Antonio J.
Published: October 2018

Background: The multi–slice computerized tomography (MSCT) is a medical imaging modality that has been used to determine the size and location of the stomach cancer. Additionally, MSCT is considered the best modality for the staging of gastric cancer. One way to assess the type 2 cancer of stomach is by detecting the pathological structure with an image segmentation approach. The tumor segmentation of MSCT gastric cancer images enables the diagnosis of the disease condition, for a given patient, without using an invasive method as surgical intervention.

Methods: This approach consists of three stages. The initial stage, an image enhancement, consists of a method for correcting non homogeneities present in the background of MSCT images. Then, a segmentation stage using a clustering method allows to obtain the adenocarcinoma morphology. In the third stage, the pathology region is reconstructed and then visualized with a three–dimensional (3–D) computer graphics procedure based on marching cubes algorithm. In order to validate the segmentations, the Dice score is used as a metric function useful for comparing the segmentations obtained using the proposed method with respect to ground truth volumes traced by a clinician.

Results: A total of 8 datasets available for patients diagnosed, from the cancer data collection of the project, Cancer Genome Atlas Stomach Adenocarcinoma (TCGASTAD) is considered in this research. The volume of the type 2 stomach tumor is estimated from the 3–D shape computationally segmented from the each dataset. These 3–D shapes are computationally reconstructed and then used to assess the morphopathology macroscopic features of this cancer.

Conclusions: The segmentations obtained are useful for assessing qualitatively and quantitatively the stomach type 2 cancer. In addition, this type of segmentation allows the development of computational models that allow the planning of virtual surgical processes related to type 2 cancer.
On the Educational-Methodical Complex of Discipline «Engineering and Computer Graphics» in Terms of Modernization of the Course of Descriptive Geometry
Authors: Поликарпов Юрий , Polikarpov Yuriy , Семашко М. , Semashko M. , Худякова Л. , Hudyakova L.
Published: October 2018

In connection with the use of machine-building enterprises to create new products of computer-aided design, which solve the problem in three-dimensional space, the problem of modernization of the course of descriptive geometry becomes relevant. The article describes the experience of the Department of descriptive geometry and drawing of the Ufa state aviation technical University for the modernization of the course of descriptive geometry. The questions of development of educational and methodical complex of the modernized discipline “engineering and computer graphics”, about its components which are prepared by Department and are used in educational process at training of bachelors in the directions which are included in the enlarged group of 150000 «Mechanical engineering» are in detail considered.
Practical Component of Technical Education — the Basis of Formation of the Agroengineer
Authors: Шарая О. , Sharaya O. , Водолазская Н. , Vodolazskaya N. , Пастухов А. , Pastukhov A. , Стребков С. , Strebkov Sergey , Бережная И. , Berezhnaya I.
Published: October 2018

The higher school of agrarian education in Russia represents the uniform system including — three levels of the higher education: bachelor degree and/or specialist programme; magistracy; training of the top skills. The university realizes educational programs of the higher education of all levels for a wide range of specialties. It carries out basic and applied scientifi c research in a wide range of sciences. Tendencies and the prospects of development of the highest education in Russia consist in strengthening of practical orientation of education, introduction in educational programs of practical disciplines, involvement of experts teachers. Relevant requirements of modern employers are the cornerstone of training programs. Master classes and seminars with participation of heads of large agrarian and machine-building enterprises, businessmen, managers and representatives of farms are held. Improvement of quality of educational services is reached by application in educational process of multimedia technologies, the systems of visualization, universal introduction of technologies of distance and electronic learning. For this purpose it is necessary to increase the mobility of teachers and students and a possibility of access to modern agrarian technologies both on internal, and at the external levels, by professional development in holdings and the companies of an agricultural profi le and foreign training. This work raises the questions of practical use of the theoretical knowledge and practical skills and abilities forming competences of the provided federal state educational standards on the example of trainings and master classes in all-technical disciplines. The gained knowledge and the created competences will be a basis of professional mobility and readiness of future young specialists for the effective solution of the tasks and problems arising in the sphere of their production activity. Thus, researches of practical orientation of education of agroengineers on the example of Belgorod State Agricultural University named after V.Ya. Gorin is a relevant task.
Optimal Product Design by Sequential Experiments in High Dimensions
Authors: Joo Mingyu , Thompson Michael L. , Allenby Greg M.
Published: October 2018

The identification of optimal product and package designs is challenged when attributes and their levels interact. Firms recognize this by testing trial products and designs prior to launch, during which the effects of interactions are revealed. A difficulty in conducting analysis for product design is dealing with the high dimensionality of the design space and the selection of promising product configurations for testing. We propose an experimental criterion for efficiently testing product profiles with high demand potential in sequential experiments. The criterion is based on the expected improvement in market share of a design beyond the current best alternative. We also incorporate a stochastic search variable selection method to selectively estimate relevant interactions among the attributes. A validation experiment confirms that our proposed method leads to improved design concepts in a high-dimensional space compared with alternative methods.

This paper was accepted by Eric Anderson, marketing.
School Performance of the Moroccan Students in the Spanish Educational System: The Municipality of Collado Villalba (Madrid Region)
Authors: Koroutchev Rossen Kostadinov
Published: October 2018

In the present paper we analyse the school performance of the Moroccan secondary students in the municipality of Collado Villalba (Northern Madrid region). For this aim we discuss several socio-economic parameters such as the evolution of unemployment, vegetative growth or immigration rate, etc., that are related to school performance and perspectives in general. Our results show that the municipality has better parameters in terms of school performance and integration of the Moroccan students, compared to the average values of the Madrid region (and the country in general). There is even an improvement of the above parameters, compared to previous years, probably due to the better socio-economic characteristics of the municipality during the recent years, and to the educational and pedagogical effort from part of the municipality.
An Investigation of the Effectiveness of Doing Sports Situation, Gender and Age Variations in Sadness Management in Children
Authors: Nas Kazim , Temel Veysel
Published: October 2018

This study was conducted with the aim of investigating the effect of doing sports, gender and age variables on sadness management of students. The universe of the research was 558 students (age average = 11,96 ± 1,29), including 308 female and 250 male students studying in the secondary school of in Karaman between 2017-2018 period. In addition to the personal information form prepared by the researcher as a data collection tool in the research, "Child Sadness Management Scale" developed by Zeman et al., adapted to the Turkish language by Akin et al. was used. MANOVA and ANOVA analysis were performed in the solution and interpretation of the data. At the end of the study; it can be said that the levels of Inhibition from the sadness management sub-dimensions of the participants are in the middle level, Emotion Regulation Coping levels are above the mid - level and Dysregulated-Expression levels are low. There was a significant difference between doing sports variable of the participants and the Inhibition dimension and between the gender variable and sub-dimension of the Dysregulated-Expression, but there was no significant difference between age variable and sub-dimensions of the sadness management.
Mindful Self-Care Scale (MSCS): Adaptation and Validation in a Normative Turkish Sample
Authors: Aydin-Sunbul Zeynep , Malkoc Asude , Aslan-Gordesli Meltem , Arslan Reyhan , Cekici Ferah
Published: October 2018

The aim of this study was to adapt and validate Mindful Self-Care Scale (MSCS) with a normative Turkish sample. Participants of the study were 330 university students (232 females and 97 males) along with the age mean of 20.22 (SD=1.32). In order to validate the six factor structure of Mindful Self-care Scale, a confirmatory factor analysis was conducted. For providing evidence over convergent validity, Mindful Attention Awareness Scale-Adolescent version (Brown, West, Loverich & Biegel, 2011) was concurrently used. The results of the confirmatory factor analysis  displayed satisfactory evidence for the six factor Mindful Self-Care Scale (χ2 / df = 1.7; GFI = 0.87, CFI = 0.92; TLI = .91; RMSEA = 0.05). The scale was also found to be significantly correlated to Mindful Attention Awareness Scale-Adolescent (r=.27, p<.001). Also, the Cronbach Alpha value for the whole scale was found .89 yielding satisfactory evidence for the internal consistency of the instrument. The results of the study tentatively yielded that the Mindful Self-Care Scale is a valid and reliable assessment tool of self-care in Turkish culture. As well, further studies examining the psychometric properties of Mindful Self-Care Scale are still needed with larger and diverse samples.
The cost-effectiveness of dual mobility in a spinal deformity population with high risk of dislocation
Authors: Elbuluk A. M. , Slover J. , Anoushiravani A. A. , Schwarzkopf R. , Eftekhary N. , Vigdorchik J. M.
Published: October 2018

Aims

The routine use of dual-mobility (DM) acetabular components in total hip arthroplasty (THA) may not be cost-effective, but an increasing number of patients undergoing THA have a coexisting spinal disorder, which increases the risk of postoperative instability, and these patients may benefit from DM articulations. This study seeks to examine the cost-effectiveness of DM components as an alternative to standard articulations in these patients.

Patients and Methods

A decision analysis model was used to evaluate the cost-effectiveness of using DM components in patients who would be at high risk for dislocation within one year of THA. Direct and indirect costs of dislocation, incremental costs of using DM components, quality-adjusted life-year (QALY) values, and the probabilities of dislocation were derived from published data. The incremental cost-effectiveness ratio (ICER) was established with a willingness-to-pay threshold of $100 000/QALY. Sensitivity analysis was used to examine the impact of variation.

Results

In the base case, patients with a spinal deformity were modelled to have an 8% probability of dislocation following primary THA based on published clinical ranges. Sensitivity analysis revealed that, at its current average price ($1000), DM is cost-effective if it reduces the probability of dislocation to 0.9%. The threshold cost at which DM ceased being cost-effective was $1180, while the ICER associated with a DM THA was $71 000 per QALY.

Conclusion

These results indicate that under specific clinical and economic thresholds, DM components are a cost-effective form of treatment for patients with spinal deformity who are at high risk of dislocation after THA. Cite this article: Bone Joint J 2018;100-B:1297–1302.
O IMPACTO DE ESTÁGIOS NO EXTERIOR SOBRE O DESENVOLVIMENTO ACADÊMICO DE ESTUDANTES DO CURSO DE FARMÁCIA DA UNIVERSIDADE DE SÃO PAULO: UM ESTUDO DE CASO DE 10 ANOS
Authors: Tavares Maurício Temotheo , Ferreira Luiza Silva , Primi Marina Candido , Giarolla Jeanine , Parise-Filho Roberto
Published: October 2018

A internacionalização do ensino superior foi incorporada às diretrizes das universidades brasileiras e estágios no exterior são bons exemplos desta medida. Nos últimos anos, a procura por estágios internacionais tem aumentado, porém, a literatura carece de avaliações sobre as contribuições desta política. Neste sentido, o presente trabalho avalia o envolvimento de alunos de graduação da Faculdade de Ciências Farmacêuticas da Universidade de São Paulo em estágios no exterior e o impacto das experiências sobre a vida pessoal, profissional e acadêmica dos estudantes. Os dados foram coletados por um questionário aplicado a ex-alunos que realizaram estágios no exterior entre 2007-2016. Os resultados indicaram que os destinos mais frequentes dos estágios foram Canadá, Inglaterra, Austrália e Estados Unidos. O programa Ciência sem Fronteiras financiou 89% de todas as bolsas de estudo aprovadas. As principais motivações dos alunos para execução do estágio internacional incluíram: melhorar a proficiência na língua estrangeira, ter experiência no exterior e fortalecer a carreira profissional. Apenas 19% puderam receber créditos equivalentes em disciplinas obrigatórias cursadas no exterior. 91% validaram disciplinas eletivas. O apoio institucional aos estudantes; infraestrutura; acesso à biblioteca ou tecnologia da informação; e estratégias de aprendizado são os principais aspectos que precisam ser melhorados na FCF-USP.
Notes from the Editors, October 2018
Authors: Editors -
Published: October 2018

buy this issue

This issue is dedicated to remembering the life and work of Samir Amin (1931–2018), the greatest single theorist of imperialism of the late twentieth and early twenty-first century, and one of the leading world activists and organizers in today's anti-imperialist struggle.
Isyarat Bertindak sebagai Faktor Pendorong Lelaki Seks Lelaki dalam Melakukan Voluntary Counseling and Testing
Authors: Nugroho Cahyo , Kusumaningrum Tanjung Anitasari Indah
Published: October 2018

Latar Belakang: Berdasarkan data Komisi Penanggulangan AIDS Kabupaten Sukoharjo pada tahun 2017, Lelaki Seks dengan Lelaki (LSL) merupakan kelompok risiko HIV tertinggi. Voluntary Counselling and Testing (VCT) merupakan salah satu strategi deteksi dini HIV dan sebagai pintu masuk ke seluruh layanan kesehatan HIV/AIDS. Penelitian ini bertujuan untuk mendeskripsikan perilaku pemanfaatan Klinik VCT oleh LSL di Sukoharjo.   Metode: Jenis penelitian ini merupakan penelitian kualitatif dengan pendekatan studi kasus terhadap lima LSL sebagai informan utama yang rutin dan tidak pernah tes HIV.  Teknik pengumpulan data dengan cara wawancara mendalam kepada informan utama dan dua informan triangulasi terdiri dari satu orang Peer Educator dan satu orang Koordinator Lapangan.Hasil: Hasil penelitian menunjukkan bahwa seluruh informan sudah pernah melakukan VCT walaupun dengan mandatory melalui perkumpulan LSL, namun hanya empat orang yang melakukannya secara rutin. Faktor-faktor yang menjadi penyebab informan rutin dalam melakukan VCT setiap 3 bulan adalah persepsi kerentanan yang besar, persepsi keseriusan yang tinggi, persepsi manfaat tes yang cukup besar, persepsi hambatan terhadap tes yang rendah, serta cukup banyaknya isyarat untuk bertindak yang terpapar kepada informan dan tingginya persepsi kemampuan diri untuk tes. Tetapi bila didalami lagi banyaknya isyarat bertindak yang dialami informan terutama adalah contoh yang diperlihatkan oleh teman sebaya. Sedangkan bagi informan yang tidak melakukan VCT secara rutin penyebabnya adalah rendahnya kemampuan diri untuk tes. Sehingga peneliti menyarankan kepada petugas perlu peer educator yang rajin untuk memotivasi kelompoknya untuk melakukan tes dan memberikan informasi yang lebih lengkap terhadap dampak penularan HIV kepada LSL dan pasangannya untuk mencegah penularan serta mengurangi stigma dan diskriminasi oleh petugas kesehatan dalam layanan kesehatan.Kata Kunci: HIV/AIDS, Lelaki Seks dengan Lelaki, tes HIV, persepsi, HBM
URGENSI PROTEKSI PEMERINTAH TERHADAP USAHA KECIL DAN MENENGAH: Studi kasus di Desa Pledokan Kecamatan Sumowono Kabupaten Semarang Provinsi Jawa Tengah
Authors: Munadi M.
Published: October 2018

Usaha Kecil dan Menengah (UKM) di Indonesia memiliki potensi laten atau tersembunyi yang sangat besar untuk bisa dikembangkan lebih jauh lagi. Berkaca dari sejarah, UKM menjadi salah satu sektor yang mampu bertahan dari deraan krisis ekonomi 1998 yang pernah melanda Indonesia. Ketika banyak perusahaan besar gulung tikar, UKM justru semakin banyak bermunculan. UKM bisa ikut mendorong pertumbuhan potensi ini dengan menyediakan pembiayaan yang diperlukan. Selama ini pinjaman yang diberikan oleh Bank, misalnya, kepada UKM cukup besar. Para pelaku usaha juga tidak memiliki kredit macet yang besar perputaran uang bisa terus berjalan dengan baik. Metode penelitian yang digunakan dalam riset ini adalah deskriptif kualitatif yakni data yang diperoleh dari hasil wawancara dan pengamatan. Sedangkan metode pengumpulan data yang digunakan dalam penelitian ini adalah wawancara, observasi dan dokumentasi. Hasil penelitian yang dilakukan terhadap UKM di Desa Pledokan Kecamatan Sumowono Kabupaten Semarang ini menunjukkan bahwa Pemerintah perlu meningkatkan perannya dalam memberdayakan UKM disamping mengembangkan kemitraan usaha yang saling menguntungkan antara pengusaha besar dengan pengusaha kecil, dan meningkatkan kualitas Sumber Daya Manusianya. Pengembangan terhadap sektor swasta merupakan suatu hal yang tidak diragukan lagi perlu untuk dilakukan. Pemerintah pada intinya memiliki kewajiban untuk turut melindungi UKM dengan memecahkan tiga hal masalah klasik yang kerap kali menerpa mereka, yakni akses pasar, modal, dan teknologi yang selama ini kerap menjadi pembicaraan di seminar atau konferensi. Perlu disadari, UKM berada dalam suatu lingkungan yang kompleks dan dinamis. Jadi, upaya mengembangkan UKM tidak banyak berarti bila tidak mempertimbangkan pembangunan (khususnya ekonomi) lebih luas. Konsep pembangunan yang dilaksanakan akan membentuk ‘aturan main’ bagi pelaku usaha (termasuk UKM) sehingga upaya pengembangan UKM tidak hanya bisa dilaksanakan secara parsial, melainkan harus terintegrasi dengan pembangunan ekonomi nasional dan dilaksanakan secara berkesinambungan.
PEMBENTUKAN KEBIJAKAN PARTISIPATIF DALAM PERSPEKTIF PEMERINTAHAN KOLABORATIF DI KABUPATEN SAMBAS PROVINSI KALIMANTAN BARAT
Authors: Mulyadi Willy
Published: October 2018

Convensional model of public policy makings in Sambas district, West Borneo Province, so far rely more on the strength of institutional structures and elites with less open processes. The impact in many case of planning has failed to identify and accommodate governance issues. This research uses qualitative explorative methods which are assisted with soft system methodology as suggester by Checkland (1999). Analysis of research uses collaborative governance theory in looking at the process of preparation of regional medium term development plan (RPJMD) of 2016-2021. Result of this research illustrates that the failure in the preparation of planning for this is caused by access to stakeholder involvement that is limited, the role of the government is very dominant so that RPJMD is not considered as a shared commitment and responsibility, the implication of each party working independently in accordance with their respective interest. It is also apparent that the process of preparing planning has not been sufficient to meet accessability and drivers in the form of citizen's education and lack of seriousness in the implementation of bureaucratic reform to become an implementative reference for the formation of participatory policy making according to the perspective of collaborative governance in regions with similar characteristics.
An Empirical Research about Xinjiang Minority College Students’ Value Recognition in Inner-Mainland's Universities of China
Authors: Zhu Hai-Long
Published: October 2018

In order to understand value recognition deeply, the research was taken to 1128 Xingjiang minority college students in inner-mainland 36 universities of China by the questionnaire with five dimensions which political value, moral value, cultural psychology, language stress and environmental stress. The result showed that there was an order tendency in their values, in order, cultural psychology, moral values, political values, language stress and environmental stress. At the same time, there are gander differences. Male and female college students do not exist significant differences in cultural psychology and moral value dimensions. But the differences being in the political values, language stress and environmental stress. Xinjiang minority college students are fundamentally the same as Han nationality students in political values and moral values, but obvious differences in cultural psychology, language stress and environmental stress.
Towards Masculinity As an Ethical Project. An Outline of the Philosophical and Social Situation
Authors: Górecki Przemysław
Published: October 2018

The article is an attempt at addressing the problem of "masculinity" as a historically privileged category in the social and philosophical tradition. In the dichotomous gender system, femininity is usually valued as aesthetic quality, while masculinity stands as an ethical value. This distinction, suggesting the subordinated and disadvantaged position of "femininity" derives from ancient philosophy and biblical tradition and was strengthened not only by philosophical writings but also by symbolic, legal, economic and social practices. By sketching a review of positions and confronting the stereotypical image of "masculinity" with the complex reality of multiple forms of masculine expressions, the article brings the situation of "masculinity" in the world organized by the phallogocentric symbolic order.
Co zrobić z bestią? Metafora jako narzędzie kategoryzacji niektórych ludzi na przykładzie ustawy z dnia 22 listopada 2013 r. o postępowaniu wobec osób z zaburzeniami psychicznymi stwarzających zagrożenie życia, zdrowia lub wolności seksualnej innych osób
Authors: Wojtczak Sylwia
Published: October 2018

The paper is to show the consequences of using in public and legal discourse some expressions, which disseminate certain metaphors in the individual and collective cognition. The analysed example is the expression ‘the act about the beasts’ used widely in Poland towards an act of 22 of November 2013 abouta procedure towards persons with psychic disorders resulting a risk for life, health and sexual freedom of other persons. Such an identification of the act has been a realization of the metaphor PERSON WITH PSYCHIC DISORDERS RESULTING A RISK FOR LIFE, HEALTH AND SEXUAL FREEDOM OF OTHER PERSONS IS A BEAST. This metaphor may be a psychological means to facilitate dehumanized perception of certain human beings.
Agrarne początki kapitalizmu
Authors: Meiksins Wood Ellen
Published: October 2018

Tekst przedstawia podstawowe założenia i tezy „marksizmu politycznego”. Autorka wykazuje, jak i dlaczego początki kapitalizmu należy wiązać w pierwszej kolejności z wsią i rolnictwem, a dopiero w drugiej z miastem i handlem. Podporządkowanie procesów produkcji żywności imperatywom kapitalizmu stanowi o rewolucjonizującym charakterze kapitalizmu, gdyż przekształceniu ulegają w ten sposób procesy odpowiedzialne za samą reprodukcję społeczeństwa, a nie jedynie dystrybucji lub redystrybucji nadwyżek.(1942-2016) – była amerykańską historyczką marksistowską i teoretyczką. Wraz z Robertem Brennerem stworzyła nurt nazywany „marksizmem politycznym”. Autorka wielu książek między innymi The Retreat from Class (1986), za którą otrzymała nagrodę im. Isaaca Deutschera, oraz wpływowej pracy The Origin of Capitalism (1999). <w:LsdException Locked="false" Priority="51" Name="Grid Table 6 Colorful Accent 2
Od walki klas do zderzenia cywilizacji. Geopolityka i ekonomia polityczna islamofobii
Authors: Wielgosz Przemysław
Published: October 2018

Artykuł jest próbą zarysowania ekonomicznych i politycznych ram oraz historycznego procesu formowania się współczesnych postaci islamofobii. Autor wskazuje, że odbywało się to na dwóch poziomach – geopolitycznym oraz wewnętrznym, realizowanym na poziomie państw narodowych. Proces ten wpisuje się w kryzys hegemonii zachodniej w globalnym systemie kapitalistycznym oraz strukturalny kryzys gospodarczy kapitalizmu. Islamofobia okazuje się funkcjonalnym narzędziem zarządzania kryzysami. Po pierwsze, stanowi element legitymizacji polityki imperialistycznej, kreując obraz nowego wroga Zachodu. Po drugie, jest narzędziem neoliberalnej polityki „dzielenia i rządzenia” klasami podporządkowanymi w Europie i Ameryce Północnej.
Comparative in vitro/theoretical studies on the anti-angiogenic activity of date pollen hydro-alcoholic extract: Highlighting the important roles of its hot polyphenols
Authors: Rasouli Hassan , Norooznezhad Amir Hossein , Rashidi Tahereh , Hoseinkhani Zohreh , Mahnam Azadeh , Tarlan Mitra , Moasefi Narges , Mostafaei Ali , Mansouri Kamran
Published: October 2018

Introduction: Date palm pollen (DPP) is the male reproductive soft powder from date flowers widely used as the valuable dietary supplement to fortify the size of testis and ovarian to increase the power of sex. This part of date palm significantly exhibited anti-diabetic, anti-inflammation and protective effects against male and female infertility. Though the anticancer activity of date fruits was previously reported, the DPP anti-angiogenic effects were not reported, and as the first study, its inhibitory effects were examined in the current study. Methods: The DPP soft powder was collected to prepare its hydro-alcoholic extract to examine its anti-angiogenic activity in an in vitro model. At different concentrations, the cytotoxicity of the prepared extract was examined on human umbilical vein endothelial cells (HUVECs) using lactate dehydrogenase method. Cell proliferation was determined using the MTT assay and cytodex-3D model in collagen gel was used to assay its possible anti-angiogenic activity. The expression of VEGF, MMP-2 and MMP-9 genes was measured using real-time polymerase chain reaction (PCR). Finally, molecular docking simulation was used to highlight the possible role of DPP polyphenols to interact with the associated receptors. Results: The prepared hydro-alcoholic extract exhibited significant anti-angiogenic activity in a dose-dependent manner and decreased the endothelial cell proliferation. The calculated IC50 value for the examined extract in angiogenesis model was 260 µg·mL, respectively. Also, the expression of VEGF, MMP-2 and MMP-9 genes were significantly decreased. Docking simulation results unveiled that the isolated DPP polyphenols have the affinity to interact with ctDNA, VEGF and its receptors. Conclusion: The DPP is the new source of non-toxic anti-cancer agents to use as a dietary supplement in the pre-treatment of cancer.
An fMRI investigation of the neural correlates underlying the autonomous sensory meridian response (ASMR)
Authors: Lochte Bryson C. , Guillory Sean A , Richard Craig A. H. , Kelley William M.
Published: October 2018

Introduction: The "autonomous sensory meridian response" (ASMR) is a neologism used to describe an internal sensation of deep relaxation and pleasant head tingling which is often stimulated by gentle sounds, light touch, and personal attention. Methods: An fMRI-based methodology was employed to examine the brain activation of subjects prescreened for ASMR-receptivity (n=10) as they watched ASMR videos and identified specific moments of relaxation and tingling. Results: Subjects who experienced ASMR showed significant activation in regions associated with both reward (NAcc) and emotional arousal (dACC and Insula/IFG). Brain activation during ASMR showed similarities to patterns previously observed in musical frisson as well as affiliative behaviors. Conclusion: This is the first study to measure the activation of various brain regions during ASMR and these results may help to reveal the mechanistic underpinnings of this sensation.
Recent advances in improving oral drug bioavailability by cocrystals
Authors: Emami Shahram , Siahi-Shadbad Mohammadreza , Adibkia Khosro , Barzegar-Jalali Mohammad
Published: October 2018

Introduction: Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy. Improving oral absorption of drugs with low water solubility and/or low intestinal membrane permeability is an active field of research. Cocrystallization of drugs with appropriate coformers is a promising approach for enhancing oral bioavailability. Methods: In the present review, we have focused on recent advances that have been made in improving oral absorption through cocrystallization. The covered areas include supersaturation and its importance on oral absorption of cocrystals, permeability of cocrystals through membranes, drug-coformer pharmacokinetic (PK) interactions, conducting in vivo-in vitro correlations for cocrystals. Additionally, a discussion has been made on the integration of nanocrystal technology with supramolecular design. Marketed cocrystal products and PK studies in human subjects are also reported. Results: Considering supersaturation and consequent precipitation properties is necessary when evaluating dissolution and bioavailability of cocrystals. Appropriate excipients should be included to control precipitation kinetics and to capture solubility advantage of cocrystals. Beside to solubility, cocrystals may modify membrane permeability of drugs. Therefore, cocrystals can find applications in improving oral bioavailability of poorly permeable drugs. It has been shown that cocrystals may interrupt cellular integrity of cellular monolayers which can raise toxicity concerns. Some of coformers may interact with intestinal absorption of drugs through changing intestinal blood flow, metabolism and inhibiting efflux pumps. Therefore, caution should be taken into account when conducting bioavailability studies. Nanosized cocrystals have shown a high potential towards improving absorption of poorly soluble drugs. Conclusions: Cocrystals have found their way from the proof-of-principle stage to the clinic. Up to now, at least two cocrystal products have gained approval from regulatory bodies. However, there are remaining challenges on safety, predicting in vivo behavior and revealing real potential of cocrystals in the human.
The Role of Public Health Centers (Puskesmas) as the Gatekeeper of National Health Insurance
Authors: Anita Betri , Febriawati Henni , Yandrizal Yandrizal
Published: October 2018

The percentages of referrals for the first level health facilities visits are coming from the health center (Puskesmas) with 16.85% at the highest and from the practicing doctors with 12.45% at the lowest. The aim of the research is to examine the efficiency the promotion, preventive and curative care quality improvement. This study used qualitative exploratory design by case study approach. The collection of data was conducted through field observations, document observation and in-depth interviews. TThe informants consisted of 4 Head of Health Center/Puskesmas, 9 cadres of integrated guiding posts (Pos Pembinaan terpadu /Posbindu) for Non-Communicable Diseases (NCDs), 9 cadres of Integrated Service Post (Pos Pelayanan Terpadu/Posyandu), 33 participants of the National Health Insurance and 23 people from community who have not joined the national health insurance scheme. The results show that mini workshops are held every month in preparing activities with a focus on the causes of most diseases in the previous month. Posyandu may reduce morbidity rate on infants and pregnant women, Posbindu for Non-communicable Diseases can prevent and control non-communicable diseases. Quality of service can improve the perception of the quality of the service and can reduce referrals to hospital.
Health Workers Support, Culture and Status of Exclusive Breastfeeding in Sungai Ulin Community Health Center
Authors: Yulidasari Fahrini , Rahman Fauzie , Rani Puspa
Published: October 2018

Exclusive breastfeeding is the most important nutrition for baby until 6 months old without any food or drinks addition. Based on Basic Health Research (Riskesdas) 2013, in Indonesia mother who exclusively breastfeeding her baby was still low only 38% while the government policy is targeting 80% in 2010. Furthermore, there was only 13,46% breastfeeding coverage in Sungai Ulin community health center in August 2015. The main factors that cause low exclusive breastfeeding coverage such as health worker support and culture of breastfeeding provision. The objective of this research is to determine correlation between health workers support and culture of breastfeeding with status of exclusive breastfeeding in the area of Sungai Ulin Community Health Center. This research used observational analytic method with case-control design, conducted in 2016. The sample in this study were mothers who have baby aged 6-12 months with 23 as cases (non-exclusive breastfeeding) and 46 as controls (exclusive breastfeeding) or the ratio of 1:2 was determined using the hypothesis test 2 proportion formula. The research used simple random samping technique using univariate and bivariate analysis with Chi-square test with 95% confidence level. The results showed there was correlation between health workers support (p-value = 0,013, OR = 6,271) and culture of exclusive breastfeeding provision (p-value = 0,0001, OR = 8,906) with status of exclusive breastfeeding.
Health, Food Consumption, Social Economy, and Stunting Incidency in Timor Leste
Authors: Pacheco Cipriano Do Rosario , Picauly Intje , Sinaga Mindo
Published: October 2018

Stunting can affect the health of toddlers. The prevalence of stunting in Timor Leste in 2014 is 50.2%, whereas in Aileu District is 52.3%. Stunting can interfere intellectual growth and development. The purpose of this study was to analyze the relationship between stunting determinants. The research design was cross sectional. The population of this study was toddlers 24-59 months old, with a sample size of 102 people. Sampling technique used was simple random sampling. Data were analyzed bivariately using simple linear regression, while multivariate analysis was performed using multiple logistic regressions. Bivariate analysis revealed variables that have significant relationship with stunting: immunization (p=0.026), infectious disease (p=0.049), income (p=0.003), total family member (p=0.045). Multivariate analysis obtained two variables as determinant factor of stunting: infectious disease (p=0.025; OR=0.355; 95% CI=0.144-0.877), income (p=0.028; OR=0.332; 95% CI=0.124-0.887). The incidence of stunting in toddlers in Aileu District is very serious (54.9%). Toddlers with stunting demonstrated the adverse effects of stunting on growth, development, and the quality of human resources. Stunting is not only a health sector issue. It is necessary to have appropriate interventions with early and liable management through various related sectors.
Nutritional Status and Physical Fitness of Full Day Elementary School Students
Authors: Wahyudi Agung , Firmansyah Sofyan Adi , Dong Nguyen Nhat
Published: October 2018

Nutritional status can be measured through the adequacy of nutrients obtained from food which are digested every day. The increasing number of healthy food absorbed by the body can increase the physical fitness of the body.  The purpose of this research was to do counseling in order to understand the nutritional status and physical fitness level of fifth grade student at Tunas Harapan Islamic Elementary School in Sendangmulyo, Tembalang, Semarang. The physical fitness level was measured using nutritional status and physical fitness test (TKJI). The data were obtained using descriptive method with measurement and test techniques. These data were obtained from measurement of height, weight, age, and physical fitness tests (TKJI). This study found that the nutritional status of fifth grade students in Tunas Harapan Islamic Elementary School were included in normal nutrition category and moderate physical fitness level.
Clinically relevant doses of vitamin A decrease cortical bone mass in mice
Authors: Lionikaite Vikte , Gustafsson Karin L , Westerlund Anna , Windahl Sara H , Koskela Antti , Tuukkanen Juha , Johansson Helena , Ohlsson Claes , Conaway H Herschel , Henning Petra , Lerner Ulf H
Published: October 2018

Excess vitamin A has been associated with decreased cortical bone thickness and increased fracture risk. While most studies in rodents have employed high dosages of vitamin A for short periods of time, we investigated the bone phenotype in mice after longer exposure to more clinically relevant doses. For 1, 4 and 10 weeks, mice were fed a control diet (4.5 µg retinyl acetate/g chow), a diet modeled from the human upper tolerable limit (UTL; 20 µg retinyl acetate/g chow) and a diet three times UTL (supplemented; 60 µg retinyl acetate/g chow). Time-dependent decreases in periosteal circumference and bone mineral content were noted with the supplemented dose. These reductions in cortical bone resulted in a significant time-dependent decrease of predicted strength and a non-significant trend toward reduced bone strength as analyzed by three-point bending. Trabecular bone in tibiae and vertebrae remained unaffected when vitamin A was increased in the diet. Dynamic histomorphometry demonstrated that bone formation was substantially decreased after 1 week of treatment at the periosteal site with the supplemental dose. Increasing amount of vitamin A decreased endocortical circumference, resulting in decreased marrow area, a response associated with enhanced endocortical bone formation. In the presence of bisphosphonate, vitamin A had no effect on cortical bone, suggesting that osteoclasts are important, even if effects on bone resorption were not detected by osteoclast counting, genes in cortical bone or analysis of serum TRAP5b and CTX. In conclusion, our results indicate that even clinically relevant doses of vitamin A have a negative impact on the amount of cortical bone.
Multi-environment Genomic Prediction of Plant Traits Using Deep Learners With Dense Architecture
Authors: Montesinos-López Abelardo , Montesinos-López Osval A , Gianola Daniel , Crossa José , Hernández-Suárez Carlos M
Published: October 2018

Genomic selection is revolutionizing plant breeding and therefore methods that improve prediction accuracy are useful. For this reason, active research is being conducted to build and test methods from other areas and adapt them to the context of genomic selection. In this paper we explore the novel deep learning (DL) methodology in the context of genomic selection. We compared DL methods with densely connected network architecture to one of the most often used genome-enabled prediction models: Genomic Best Linear Unbiased Prediction (GBLUP). We used nine published real genomic data sets to compare a fraction of all possible deep learning models to obtain a “meta picture” of the performance of DL methods with densely connected network architecture. In general, the best predictions were obtained with the GBLUP model when genotype×environment interaction (G×E) was taken into account (8 out of 9 data sets); when the interactions were ignored, the DL method was better than the GBLUP in terms of prediction accuracy in 6 out of the 9 data sets. For this reason, we believe that DL should be added to the data science toolkit of scientists working on animal and plant breeding. This study corroborates the view that there are no universally best prediction machines.
Combinatorial Approach for Complex Disorder Prediction: Case Study of Neurodevelopmental Disorders
Authors: Huynh Linh , Hormozdiari Fereydoun
Published: October 2018

Early prediction of complex disorders (e.g., autism and other neurodevelopmental disorders) is one of the fundamental goals of precision medicine and personalized genomics. An early prediction of complex disorders can improve the prognosis, increase the effectiveness of interventions and treatments, and enhance the life quality of affected patients. Considering the genetic heritability of neurodevelopmental disorders, we are proposing a novel framework for utilizing rare coding variation for early prediction of these disorders in subset of affected samples. We provide a combinatorial framework for addressing this problem, denoted as Odin (Oracle for DIsorder predictioN), to make a prediction for a small, yet significant, subset of affected cases while having very low false positive rate (FPR) prediction for unaffected samples. Odin also takes advantage of the available functional information (e.g., pairwise coexpression of genes during brain development) to increase the prediction power beyond genes with recurrent variants. Application of our method accurately recovers an additional 8% of autism cases without any severe variant in known recurrent mutated genes with a <1% FPR. Furthermore, Odin predicted a set of 391 genes that severe variants in these genes can cause autism or other developmental delay disorders. Approaches such as the one presented in this paper are needed to translate the biomedical discoveries into actionable items by clinicians. Odin is publicly available at https://github.com/HormozdiariLab/Odin.
Genome Instability Is Promoted by the Chromatin-Binding Protein Spn1 inSaccharomyces cerevisiae
Authors: Thurston Alison K , Radebaugh Catherine A , Almeida Adam R , Argueso Juan Lucas , Stargell Laurie A
Published: October 2018

Cells expend a large amount of energy to maintain their DNA sequence. DNA repair pathways, cell cycle checkpoint activation, proofreading polymerases, and chromatin structure are ways in which the cell minimizes changes to the genome. During replication, the DNA-damage tolerance pathway allows the replication forks to bypass damage on the template strand. This avoids prolonged replication fork stalling, which can contribute to genome instability. The DNA-damage tolerance pathway includes two subpathways: translesion synthesis and template switch. Post-translational modification of PCNA and the histone tails, cell cycle phase, and local DNA structure have all been shown to influence subpathway choice. Chromatin architecture contributes to maintaining genome stability by providing physical protection of the DNA and by regulating DNA-processing pathways. As such, chromatin-binding factors have been implicated in maintaining genome stability. Using Saccharomyces cerevisiae, we examined the role of Spn1 (Suppresses postrecruitment gene number 1), a chromatin-binding and transcription elongation factor, in DNA-damage tolerance. Expression of a mutant allele of SPN1 results in increased resistance to the DNA-damaging agent methyl methanesulfonate, lower spontaneous and damage-induced mutation rates, along with increased chronological life span. We attribute these effects to an increased usage of the template switch branch of the DNA-damage tolerance pathway in the spn1 strain. This provides evidence for a role of wild-type Spn1 in promoting genome instability, as well as having ties to overcoming replication stress and contributing to chronological aging.
Polish Women in Exile to Siberia in the 19th Century – Autobiographical Reflection in Women’s Narratives
Authors: Michalska-Bracha Lidia
Published: October 2018

[full article and abstract in English]

The paper discusses the issues related to the biographical research perspective and the role of ego-documents in modern humanities. These considerations focus on autobiographical narratives of women exiled to Siberia in the 19th century, both those who were sentenced or went there voluntarily. Different forms of women’s narratives were analysed, namely a memoir of Helena Skirmuntowa (1827–1874), written in the years 1863–1867, and a diary of Maria Obuchowska-Morzycka (1841–1911?), who wrote it 40 years after her life in exile. The autobiographical research model adopted in the paper focuses not only on the questions regarding the autobiographical context of ego-documents but also on biographical and autobiographical identity of the authors, connected with the description of their life, experiences, emotions as well as their attitude to the outside world and relations with other people.
Discourse-Analysis Round Table: o dyskursie przy okrągłym stole
Authors: Senderska Joanna
Published: October 2018

[text in Polish]
The Vitality of Letters, Memoirs and Diaries from Taken Lands
Authors: Bankauskaitė Gabija
Published: October 2018

[text in English]