bluuebunny/crossref_metadata_2025 huggingface dataset:
ANTIPROLIFERATIVE AND ANTIOXIDANT EFFECTS OF CARNOSIC ACID ON HUMAN LIVER CANCER CELLS
Authors: Akın Uğur Nuri , Bakır Elçin , Ökçesiz Hacıseyitoğlu Aysun , Eken Ayşe
Published: March 2024

The purpose of the study was to investigate the cytotoxic effects of carnosic acid alone and in combination with cisplatin on human liver cancer cells and their capacity to scavenge reactive oxygen species induced in the presence or absence of hydrogen peroxide.Cytotoxic effects of agents on human liver cancer cells for 24 and 48 hours were evaluated by methyl-thiazol tetrazolium-bromide assay. Mitochondrial membrane potential were detected JC-1 kit. The intracellular reactive oxygen species levels were determined using 2’-7’dichlorofluorescin diacetateassay. According to our findings, both carnosic acid alone and in combination with cisplatin showed cytotoxic effects in human liver cancer cells at 24 and 48 hours of exposure. In particular, it was seen that the cell viability significantly decreased in a dose-dependent manner at 48 hours of exposure, and the combined treatment was found to have a more pronounced cytotoxic effect. In addition, all carnosic acid concentrations alone and in combination with cisplatin were identified to significantly reduce mitochondrial membrane potential. We observed that both carnosic acid alone and in combination with cisplatin lowered intracellular reactive oxygen species levels in the presence or absence of hydrogen peroxide. The results suggested that carnosic acid alone or in combination with cisplatin might be a promising agent in the treatment of liver cancer.
Biosorption of Zn by dried biomass of Euglena gracilis from aqueous solutions
Authors: Machalová Linda , Lempochner Tomáš , Marková Patrícia , Valica Martin , Adamcová Vanda , Hutárová Lenka , Krajčovič Juraj , Horník Miroslav
Published: March 2024

The aim of this work was to evaluate the possibility to utilize the dried biomass of Euglena gracilis var. bacillaris as a biosorbent applied for the removal of Zn from aqueous solutions. For these purposes, experiments involving solutions spiked by 65ZnCl2 were carried out under the conditions of batch systems. The prepared biosorbent in the form of dried biomass of E. gracilis (< 300 μm) was characterized in terms of the presence of functional groups (COOH, PO3H2, OH, and NH2), the concentration of binding sites cAn and the value of pHzpc = 6.6 using the modelling program ProtoFit. From the kinetics of Zn biosorption, it can be assumed that the Zn removal was a rapid process, in which the concentration equilibrium [Zn]solution : [Zn]biosorbent was stabilized in the first 5 min of interaction. In individual experiments, the effect of solution pH, initial biosorbent or Zn concentration were evaluated. Based on the MINEQL+ speciation modelling program, we predicted the decrease in the abundance of free Zn2+ cations in the presence of different concentrations of EDTA as a complexing agent in the solution. It was found that the Zn biosorption decreased linearly with the decreasing the proportion of Zn2+ in solution. The biosorption data expressed as equilibrium values of the remaining Zn concentration in solution Ceq (µmol.dm-3) and equilibrium values of specific adsorption Qeq (µmol.g-1; d.w.) were well fitted to the Langmuir model of adsorption isotherm in comparison with the Freundlich model. The maximum adsorption capacity of the dried biomass of E. gracilis for the biosorption of Zn reached the value Qmax = 0.53 ± 0.05 mmol.g-1or 34.7 ± 3.4 mg.g-1 (d.w.), respectively.
Theory-based antecedents of breastfeeding among pregnant women in the United States
Authors: Sharma Manoj , Johansen Christopher , Fudolig Miguel , Dai Chia-Liang , Kapukotuwa Sidath , Davalos Liliana , Bonsu Laurencia
Published: March 2024

Background: Breastfeeding provides several positive health benefits for the newborn child, yet breastfeeding rates remain low in the United States (US). Theory-based approaches have the potential to improve breastfeeding promotion interventions. Hence, the study examined the correlates of intention to breastfeed among US pregnant women based on the multi-theory model (MTM) of health behavior change. Methods: Using a cross-sectional design, a 36-item online survey was administered to a nationally representative sample of 315 pregnant women in the US. The instrument was psychometrically validated for face, content, and construct validity by a panel of six experts over two rounds. Further, construct validation was done by confirmatory factor analysis (CFA). Hierarchical regression modeling was employed to explain the intention to start breastfeeding and sustain exclusive breastfeeding for up to six months and with complementary foods for up to 24 months. Results: Internal consistency using Cronbach’s alpha was found to be acceptable. It was found that behavioral confidence and changes in the physical environment positively affected the initiation of breastfeeding (P<0.01; adjusted R2=0.478). All three constructs of MTM namely practice for change, emotional transformation, and changes in the social environment were significant predictors for the sustenance of breastfeeding at six months (P<0.01; adjusted R2=0.591) and at 24 months (P<0.01; adjusted R2=0.347). Conclusion: Based on the findings of this study it is essential for educators and healthcare providers to design MTM-based interventions to promote breastfeeding among pregnant women in the US.
Evaluation of Noise Pollution Levels in Selected Markets and Motor Parks in Delta State, Nigeria
Authors: Okeoghene Ijabor Blessing , Efere Jatari Timothy , Orioge Onome , Agu Fransisca Ngozi , Ogodo Oghenerabome Blossom , Okei Blessing Chiwendu
Published: March 2024

Background: The control of environmental noise pollution has been hampered by lack of sufficient knowledge of its effect on human. Noise pollution is associated with several health conditions and affects both health and behavior. This study evaluated the noise pollution level in selected market and motor parks in local government areas in Delta State. Methods: The physical parameters were measured using a digital sound level meter and a mobilebased global positioning system (GPS), in September 2021. To determine noise pollution all over the city, the noise measurements were collected in the morning and evening. The selected areas of the study were market places, road junctions/busy roads and passenger loading parks. The noise pollution levels were measured in Ogwashi-Uku Market, Ogwashi-Uku Motor Park, Nwasi Motor Park, Ibusa Market, Central Motor Park Asaba, Delta Line Park Asaba, Onitsha Park and Oko Market Asaba. Results: The results showed that the average pollution level in the morning hours were 89.33, 90.1, 90.3, 91.72, 86.59, 90.11, 92.15 and 90.3 dB in Ogwashi-Uku Market, Ogwashi-Uku Motor Park, Nwasi Motor Park, Ibusa Market, Central Motor Park Asaba, Delta Line Park Asaba, Onitsha Park and Oko market Asaba, respectively. In the evening, the corresponding measured values were 83.65, 74.90, 90.04, 90.90, 85.07, 83.44 and 91.79 dB respectively. These values were higher than the Federal Environmental Protection Agency (FEPA) and World Health Organization (WHO) standard limits for outdoor environment. Conclusion: The people who are working and living in the areas under study may be at risk of noise related health hazard due to continuous daily exposure.
Zoning of Dust Heavy Metals in Arak Plain Using Pollution Indicators and Geographic Information System (GIS)
Authors: Saberinasab Faezeh , Mortazavi Samar , Riyahi Bakhtiari Alireza
Published: March 2024

Background: In regions with heightened pollutant concentrations, especially in industrial and urban areas, dust plays a crucial role in carrying complex metal components, posing environmental challenges and health risks. This study utilized pollution indicators and geographic information system (GIS) to delineate the spatial distribution of heavy metals in the Arak plain. Methods: Dust samples from 30 stations across the Arak plain were systematically collected through random sampling. Analysis using inductively coupled plasma spectrometry (ICP-OES) allowed the calculation of pollution indices (PI) and the Nemerow Integrated Pollution Index (NIPI) for lead (Pb), zinc (Zn), copper (Cu), nickel (Ni), and iron (Fe). GIS generated spatial distribution maps depicting metal pollution. Results: The average concentrations were 45.5 mg/kg for Pb, 10.7 mg/kg for Zn, 0.47 mg/kg for Cu, 30.8 mg/kg for Ni, and 0.206 mg/kg for Fe. Analysis of PI, NIPI, and spatial distribution maps revealed heightened pollution in the northeast, center, south, and southwest areas of the Arak plain, attributed to human activities like heavy vehicle traffic, high population density, concentrated agriculture, and specific industrial operations. Conclusion: The study recommends mitigation strategies, including biological methods like phytoremediation, promotion of public transportation, mandatory environmental standards for industries, and encouragement of green practices. These initiatives aim to address and reduce environmental pollution in the Arak plain.
Health Risk Assessment for Reused Backwash Water from Saveh Water Treatment Plant
Authors: Mahdavi Mokhtar , Mahvi Amir Hossein , Mohebbi Mohammad , Teimuri Mohammad Hossein , Mamaghani Nejad Mehran , Hoseinzadeh Edris , Shamsikhani Mohammad , Jahangiri Abbas
Published: March 2024

Background: The increase in population growth, industries and living standards have caused an increasing need for drinking water in many countries. The reuse of treated water and wastewater is one of the most important options to deal with water shortage. To ensure the correctness of this work, it is necessary that the health risk assessment be reassessed during use so that consumers do not face serious problems. In this regard, the assessment of health risks assessment for the water recovered from the backwashing wastewater of the Saveh water treatment plant was investigated. Methods: To reuse the backwash wastewater from the Saveh water treatment plant, the processes of primary sedimentation and coagulation (in the form of a test jar) were investigated. Metals and heavy metals like iron (Fe), aluminum (Al), lead (Pb), Arsenic (As) and cadmium (Cd) were examined to evaluate health risks. The initial settling time was 1 hour, the coagulant used was FeCl3 made in Iran, and heavy metal contents were also measured with an Inductively coupled plasma (ICP) device. Results: The value of HRIs for Al, Fe, As, Pb and Cd in the treated spent filter backwash water (SFBW) with primary sedimentation and coagulation was less than "1" and indicates the absence of risk. Conclusion: The treated backwash wastewater treated with primary sedimentation and coagulation processes as well as raw water of the Saveh have no harmful effects in terms of heavy metals, and its reuse will not pose a risk to the health of the consumer.
Spectrum of myocardial involvement in patients with COVID-19 – An echocardiography study
Authors: Dubey Manoj kumar , Mani Avinash , Ojha Vineeta
Published: March 2024

Introduction: Covid-19 patients can have both regional and global ventricular dysfunction. We aim to study the spectrum of myocardial involvement in Covid-19 patients on echocardiography. Methods: This is a single center, observational study where wall motion abnormality patterns were studied in Covid-19 patients along with global and regional longitudinal strain analysis (GLS). Results: 30 Covid-19 patients were included in the study, with a mean age of 35.3±6.4 years. Echocardiography revealed characteristic wall motion abnormality involving hypokinesia of anterolateral and apical segments, which produced an operculum like appearance in all patients. Strain derived ejection fraction(EF) was lower in 4 chamber as compared to 2 chamber indicating regional myocardial dysfunction. Reduced GLS values in presence of normal EF indicates global systolic function impairment. Endocardial effacement was also noted in these segments along with stretching of interventricular septum. Conclusion: Specific myocardial involvement pattern can be detected on echocardiography, thus helping in diagnosis of Covid myocarditis.
Investigating the Effect of Educational Intervention Based on the Health Belief Model on Nutritional Behaviors that Prevent Cardiovascular Diseases
Authors: Okhovati Maryam , Sharifpoor Elham , Seyedzadeh Sabereh
Published: March 2024

Background: Health recommendations to adopt health behaviors are implemented by the patient if they are internalized as beliefs in the patient’s mind and are expressed in their actions. This study investigated the effect of educational intervention based on health beliefs on the nutritional behaviors that prevent cardiovascular diseases (CVDs) in middle-aged women of Sarbaz city in 2021. Methods: This interventional research was a pretest-posttest control group design. The statistical sample was 90 people, which were randomly assigned to the intervention (n=30) and control (n=60) groups. Computer-generated random numbers were used for simple randomization of subjects. First, both groups were asked to answer the questionnaires, then training was provided to the intervention group, and finally, both groups were asked to answer the questionnaires again. The data was collected using the health belief, food frequency, and nutritional behavior questionnaire (FFQ). Analysis of variance, chi-square, independent t-test, and paired t-test were used to analyze the data. Results: The findings showed that the educational intervention was effective in increasing the constructs of the health belief model that prevent CVDs (awareness, P=0.001; susceptibility, P=0.014; severity, P=0.005; benefits, P=0.020; barriers, P=0.005; selfefficacy, P=0.000). Also, the educational intervention improved nutritional behaviors that prevent CVDs (increased vegetable (P=0.001), fruit (P=0.001) consumption; reduced fat (P=0.001), and sugar (P=0.001) consumption). Conclusion: According to the findings, it can be said that increasing the awareness of middle-aged women about nutritional behaviors is a necessity to reduce the incidence of CVD risk factors.
Ocular Manifestations among Hospitalized COVID-19 Patients in the Southeast of Iran
Authors: Sharifi Ali , Mashayeskhi Paria , Nasiri Naser , Sharifi Hamid
Published: March 2024

Background: COVID-19 has a range of manifestations among different patients. Knowing the various manifestations of COVID-19 could help in better managing the infection. This study aimed to investigate the ocular manifestations of hospitalized COVID-19 patients. Methods: In this study, 379 PCR-positive COVID-19 patients hospitalized in Afzalipour hospital, a tertiary care academic medical center in Kerman city, were recruited. Demographic variables (age and sex), history of systemic diseases (diabetes mellitus and arterial hypertension), systemic COVID-19 signs and symptoms (respiratory, gastrointestinal, neurologic, and sensory), and the severity of the disease were evaluated. Patients were asked about ophthalmic symptoms. If a patient had serious ocular complaints, such as ocular pain or vision loss, and needed specialized examination, an ophthalmologist examined the patient. Results: The patients’ mean (standard deviation) age was 54.2 (15.8) years. Overall, 46 patients (12.1%, 95% confidence interval: 9.0–15.8) showed at least one ocular manifestation. The most common signs and symptoms among those with ocular manifestations were redness (n=37, 80.4%), discharge (n=35, 76.1%), lacrimation (n=31, 67.4%), itching (n=15, 32.6%), and dry eye sensation (n=15, 32.6%). Ocular manifestations were more prevalent among those≥60 years old, those with hospitalization days>7 days, those with more severe respiratory system involvement, and diabetic patients. Conclusion: One out of eight COVID-19 inpatients showed at least one ocular manifestation. As tear and ocular secretions are considered a route for coronavirus transmission, it is essential to pay attention to the early detection of ocular manifestations.
Green Hospital Standards in the Teaching Hospitals of Urmia University of Medical Sciences: Compliance Status and Providing Solutions
Authors: Shaabani Yousef , Okhovati Maryam , Sarkhosh Maryam , Vali Leila
Published: March 2024

Background: A Green Hospital is a hospital that sees the environment as a part of its service quality processes and reduces environmental risks by applying effective measures in all dimensions, including management, water, energy, and waste. This study aimed to investigate the status of Green Hospital standards in the teaching hospitals of Urmia University of Medical Sciences (UMSU). Methods: This descriptive study was conducted cross-sectionally on eight teaching hospitals associated with UMSU in 2022. The information collection tool was the Green Hospital Checklist, which consists of seven dimensions: energy, waste management, architecture, water, chemicals, supplies, and medicine. Data were collected through field observation and interviews with hospital executives. Descriptive statistics were used in SPSS 22 software for data analysis. Results: According to the results, among the eight hospitals covered by UMSU, four hospitals in the energy consumption dimension, two hospitals in the architecture dimension, one hospital in the waste management dimension, six hospitals in the chemicals dimension, and five hospitals in the medicine consumption dimension met 50% or more of the Green Hospital standards. Regarding water conservation and purchasing supplies, no hospital met the Green Hospital standards. Only one hospital met more than 50% of the Green Hospital standards overall. Conclusion: Considering that the score obtained from the studied hospitals was lower than the desired level, identifying the challenges of achieving standards in implementing Green Hospital programs is paramount. Implementing these standards requires creating a green management team and planning for the seven studied variables.
The Effect of Resistance Exercise on the Acute Response of Lipid Profile and Blood Lipid Factors in Three Different Age Groups of Wrestling Champions of Golestan province
Authors: Aghababaeyan Abolfazl , Azimi Sadegh Ali , Nikzad Mohammad Bagher
Published: March 2024

Background: Sports activity is one of the ways to improve lifestyle, and its beneficial effects on factors related to cardiovascular diseases have been well demonstrated. This study examines the effect of strenuous exercise in different age groups of wrestlers. Methods: This semi-experimental study was conducted on 21 wrestling champions of Golestan province in three age groups, including teenagers, young adults, and adults (7 people in each age group), using the availability sampling method. First, the anthropometric indices were measured, and then the lipid profile was determined before and after running on the treadmill until stagnation was achieved. To compare intra-group and inter-group averages, the paired t-test was used in dependent variables, and one-way analysis of variance statistical test was used in independent variables, and the results of lipid profile and blood lipid factors were analyzed at a significance level of P<0.05. Results: The studied wrestlers had no significant differences in terms of triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) indices before and after the implementation of the training protocol. However, the level of high-density lipoprotein (HDL) increased by 25% in adults compared to young adults. However, intra-group and inter-group changes in TG (P=0.785), TC (P=0.780), LDL (P=0.551), and HDL (P=0.180) were not statistically significant in any of the three groups. Conclusion: According to the effect of an intense resistance training session on the lipid profile in this research, to have a greater effect on training and body adaptation, it is possible to look for exercises that have the three characteristics of regularity, continuity, and moderate intensity.
The Effectiveness of Schema Therapy on Self-efficacy, Burnout, and Perfectionism of Employees with Imposter Syndrome
Authors: Bagheri Sheykhangafshe Farzin , Tajbakhsh Khazar , Savabi Niri Vahid , Mikelani Nahid , Eghbali Fatemeh , Fathi-Ashtiani Ali
Published: March 2024

Background: One of the problems in the way to success is behaviors within the framework of imposter syndrome (IS). The present study was conducted to investigate the effectiveness of schema therapy on self-efficacy, burnout, and perfectionism of employees with IS. Methods: This randomized trial employed a pre-test-post-test design with a control group. The statistical population consisted of employees from private offices in five districts of Tehran in 2019. The study participants were comprised of 40 employees who were selected through purposeful sampling and randomly assigned to either the experimental or control group. The data collection tools included questionnaires on IS, general self-efficacy, job burnout, and perfectionism. While the control group received no intervention, the experimental group underwent ten 90-minute schema therapy sessions. The data obtained were ultimately analyzed using multivariate analysis of covariance via SPSS 24. Results: According to the findings, schema therapy significantly increased self-efficacy (P<0.01, F=37.73) and decreased emotional exhaustion (P<0.01, F=30.08), depersonalization (P<0.01, F=71.63), low personal accomplishment (P<0.01, F=65.58), self-oriented perfectionism (P<0.01, F=44.28), other-oriented perfectionism (P<0.01, F=57.36), and society-oriented perfectionism (P<0.01, F=50.46) among employees with IS (P<0.001). Conclusion: Considering that employees’ performance and progress are of special importance to office managers, examining the psychological dimensions of employees to reduce IS and strengthen the sense of self-efficacy is of great importance.
Knowledge, Attitude, and Practice of Rafsanjan University of Medical Sciences Students Concerning Fast Food
Authors: Mahbobi Rad Mahmood , Pour Pasandi Abbas , Khajani Narges , Sadeghi Reza
Published: March 2024

Background: Lifestyle changes and, consequently, changes in dietary habits have led people, especially young people, to consume more processed and fast food. This study evaluated the knowledge, attitude, and practice of fast-food consumption among medical sciences students in Rafsanjan, Iran. Methods: In this cross-sectional study, data were collected using a researcher-designed self-reported questionnaire, which was distributed among 350 medical sciences students in Rafsanjan, Iran, selected by stratified random sampling from 2019 to 2020. The validity and reliability of this questionnaire were confirmed before commencement. SPSS 20 was used for data analysis. Results: The results showed that university students had above-moderate knowledge (39.7±0.55) and positive attitudes (60.52±0.43) about fast food consumption. The mean number of times students consumed fast food in the past month was 12.41±0.46. There was a statistically significant and positive correlation between attitude and practice. Also, knowledge had a significant inverse correlation with attitude and practice. The level of women’s knowledge was significantly higher (P=0.001) than men’s knowledge, and the knowledge score of dental and medical students was significantly higher (P=0.04) than that of students from other schools. The men’s attitude score was significantly higher (P=0.04) than the women’s. Conclusion: Appropriate interventions should be implemented to improve students’ knowledge, attitude, and practice concerning fast food consumption. Food labeling, teaching healthy cooking and preparation, time management, improving university meal programs, and opening affordable, healthy on-campus restaurants are recommended.
Assessment of peri-implant bone stress distribution with the effect of attachment type and implant location using finite element analysis
Authors: Aalaei Shima , Sheikhi Atefeh , Mehdian Parisa , Taghavi Farnoosh , Salimian Sara , Taghavi-Damghani Farnaz
Published: March 2024

Background. The objective of the current research was to evaluate how stress is distributed in the peri-implant bone of a mandibular overdenture with implants placed asymmetrically to the midline. Methods. A 26-year-old male’s mandible, with missing teeth, was examined using computed tomography (CT) scanning. Two implants were inserted at right angles to the occlusal plane, in the positions of the right canine and left lateral incisor of the mandible, with an internal connection. Two types of attachments (bar and ball) were designed. To simulate the clinical condition, anterior (on central incisors) and bilateral posterior (on premolars and molars) loadings were applied. The stress distribution was assessed using finite element analysis (FEA). Results. The lateral incisor level implant was found to have the highest maximum principal stress (about 33 MPa) in both models in the anterior loading condition. However, in both models, the canine-level implant revealed more stress values (about 22 MPa) in the posterior loading condition. Conclusion. In mandibular implant-supported overdentures, when implants were placed asymmetrically to the midline, one acted as a fulcrum and sustained more occlusal load. The bar attachment system did not reveal superior results in terms of stress distribution compared to the ball attachment.
An analysis of the relationship between dietary pattern changes and temporomandibular joint inflammation in diabetic rats
Authors: Noorbakhsh Seyed Amir Abas , Rafiei Mehrad , Hosseinabadi Marzieh , Amirkafi Amin , Sadeghi Mostafa , Peimani Ali
Published: March 2024

Background. The temporomandibular joint (TMJ) is the most commonly used joint in the human body. Recent studies have shown pathologic relationships between inflammation, diabetes, and musculoskeletal disorders (MSDs). Chewing disorder is a significant sign of dysfunction in the masticatory system. This study investigated dietary pattern changes in response to TMJ inflammation in diabetic rats. Methods. This experimental study was carried out on 30 male rats. The rats were fed concentrated 20-mg dietary tablets. Complete Freund’s adjuvant (CFA) was used to induce TMJ inflammation and streptozotocin (STZ) was used to induce diabetes. The animals were randomly divided into three groups (n=10), including group I (CFA+STZ), group II (healthy rats+CFA), and group III (healthy rats, no injection). Parameters such as overall food intake, food intake duration, food intake frequency, and the interval between meals were recorded in a checklist and analyzed by Mann-Whitney and Kruskal-Wallis tests (P<0.05). Results. The results showed no significant difference between groups in overall food intake and food intake frequency on days 0 and 1, but this difference was significant from day 2 to day 7. Regarding the time and end of food intake, there was a significant difference between the three groups from day 1 to day 7, but this difference was not significant on day zero. Conclusion. Dietary pattern changes were similar in the diabetic TMJ inflammation and TMJ inflammation groups. These changes can be used as a behavioral marker for TMJ inflammation in rats.
Effects of posterior intrusion using skeletal anchorage on treating anterior open bite: A systematic review and meta-analysis
Authors: Omidkhoda Maryam , Bardideh Erfan , Jahanbin Arezoo , Zarei Milad
Published: March 2024

Background. Posterior intrusion with skeletal anchorage is one of the effective methods in the treatment of anterior open bite. Knowing the effects of posterior intrusion, the amount of possible molar intrusion using skeletal anchorage, and its impact on clinical and cephalometric indicators can help the clinician choose the optimal treatment method, especially in borderline surgical cases. Methods. In this systematic review, a series of articles were collected through a systematic search in databases, and the titles and summaries of all these articles were reviewed. After removing the irrelevant articles, the full texts of the related articles were read carefully, and their validity was evaluated. Only RCTs and observational studies that complied with PICO questions were included. The Cochrane Risk of Bias 2.0 (RoB 2), ROBINS-I, and GRADE were used to assess the risk of bias in the included studies. The relevant information on selected articles was extracted, and a meta-analysis was performed with Review Manager 5.4 software. Results. The meta-analysis revealed a significant average molar intrusion of 2.89 mm using temporary anchorage devices (TADs). A subgroup analysis showed that miniplates achieved greater intrusion (3.29 mm) compared to miniscrews (2.25 mm) (P=0.03). The level of applied force did not significantly affect the degree of intrusion. Dental parameters such as overbite and overjet were notably altered, with overbite increasing by 4.81 mm and overjet decreasing by 2.06 mm on average. As for the skeletal cephalometric characteristics, SNB, ANB, and SN-Pog increased while mandibular plane angle and lower anterior facial height (LAFH) decreased, and these changes were significant. Meanwhile, SNA and palatal angle changes were not significant. Conclusion. TADs have proved effective in achieving significant intrusion of maxillary molars, leading to marked improvements in dental and skeletal characteristics in patients with open bite malocclusion. Miniplates proved more effective in achieving greater intrusion.
Effect of repeated preheating on monomer elution from a bulk-fill composite resin
Authors: Atasoy Samet , Akarsu Serdar
Published: March 2024

Background. Due to incomplete polymerization of composite resin restorations, residual monomers adversely affect their mechanical properties and biocompatibility. Preheating of composite resins is advised to increase the degree of conversion and reduce monomer elution. This study aimed to analyze the effect of preheating and repeated preheating on the amount of monomer released from a bulk-fill composite resin. Methods. Forty samples were prepared using Filtek One Bulk Fill Restorative composite resin. Samples in one group were fabricated at room temperature, whereas the composite resins in the other groups were cured after 1, 10, or 20 repeated preheating cycles (55 °C), 10 in each group. Eluted urethane dimethacrylate (UDMA) and bisphenol-A-glycidylmethacrylate (BisGMA) monomers were measured with high-performance liquid chromatography (HPLC) 24 hours and 30 days after immersion. The data were evaluated using one-way ANOVA and post hoc Tukey tests. Paired-sample t tests were used to test the differences between time intervals. Results. At both time intervals, the greatest amounts of released BisGMA, UDMA, and total monomers were obtained from the control group, whereas 10 preheating cycles resulted in the least monomer elution. The decrease in monomer elution was not statistically significant after 10 preheating cycles compared with that after one preheating cycle (P>0.05). The group with 20 preheating cycles showed a greater amount of monomer elution compared to that with 1 and 10 cycles, which was statistically significant (P < 0.05). The amount of released monomers on day 30 was significantly higher than on day 1 (P<0.01). Conclusion. Preheating of the bulk-fill composite resin was shown to be effective in reducing monomer elution. However, monomer elution was adversely affected after repeated preheating cycles of 20.
Sustainable development of horticulture: methodological approaches to sustainability assessment and its modeling
Authors:   L.P. Symyrenko Research Station of Pomology of IH NAAS, Kostyuk L.A.
Published: March 2024

The substantiation of the methodology for assessing the sustainable development of horticulture is presented and its model is proposed. Research in the context of a systemic approach allows us to define the sustainable development of the horticulture industry as a state of its economy that ensures sustainable reproduction of the industry's production potential, the goal of which is to satisfy the demand for fruit and berry products, improve the quality of life of the population and environmental safety. Intensification of horticulture on an innovative basis is an irreplaceable direction of its sustainable and stable development. The creation of highly productive gardens and their effective use based on the principles of environmental sustainability is impossible without consistent improvement of equipment, technology and organization of production. Thus, the sustainable development of the industry as an economic system is possible under the condition of maximizing the innovation factor and sufficient investment support for the reproduction of the production base. To formalize the model for assessing the stability/sustainability of the development of the horticulture industry, it is advisable to use the following criteria, indicators and indices (in statics and dynamics): gross collection of fruit and berry products, thousand tons; area of perennial plantations, thousand hectares; productivity of fruit and berry plantations, t/ha; production profitability level, %; production of fruits and berries per person, kg (self-sufficiency level); production of planting material, thousands of pieces; planting area, thousands of hectares; number of investments in the industry, UAH million; the number of completed scientific and scientific and technical works in the field of horticulture; the number of implemented innovative developments. As general indicators of the sustainability of the industry development, it is proposed to use the rate (coefficient) of growth (Tzr) - the ratio of two levels, one of which is taken as a basis for comparison, for the specified indicators (criteria) and the integral indicator the coefficient of sustainability (Ks) - as a product of the indexes of these same indicators. Key words: horticulture, sustainable development, criteria, assessment, indicators, model.
New perspective pear (Pirus communis L.) cultivars bred at the Prydnistrovska Research Station of Horticulture, IH NAAS of Ukraine
Authors:   Prydnistrovska Research Station of Horticulture, IH NAAS, Havrylets N.I. , Mykychuk O.I. ,   Prydnistrovska Research Station of Horticulture, IH NAAS, Kazantsev M.V. ,   Institute of Horticulture of the National Academy of Agrarian Sciences of Ukraine
Published: March 2024

Pear is a priority crop for Prykarpattia and Naddnistrianshchyny. This is facilitated by the natural and climatic conditions of the region. Therefore, at the Prydnistrovska Research Station of Horticulture, IH NAAS, the main directions of scientific work are the creation of new high-yielding varieties of autumn and winter ripening periods, which are characterized by high marketable fruit qualities, winter hardiness, resistance to major diseases and are well adapted to local growing conditions. As a result of many years of work of breeders of the station V.I. Saiko and L.F. Satina varieties of autumn, winter and late-winter ripening periods were obtained: ‘Bukovinka’, ‘Burshtynova’, ‘Zveniachynska’, ‘Krunpoplidna’, ‘Osin Bukovyny’, ‘Chernivchanka’, ‘Khotynchanka’, ‘Kucherianka’, ‘Storozhynetska’, ‘Yablunivska’. These varieties are grown in different regions of Ukraine. The article presents the results of breeding research on the breeding of new varieties and elite forms of pear selection at the research station. Namely, ‘Lastivka’, ‘Legenda of the Carpat’, ‘Saiva’ and hybrids 1-8-45/00, 2-14-22/05, which are characterized by a complex of economic and valuable traits. Varieties and hybrids of the intensive type, quick-fruiting, with high productivity potential and resistance to major diseases. Fruiting on the forest pear rootstock was early (third to fifth year after planting). The average yield for planting schemes of 4.5 x 3 m was 37.2 t/tree (27.5 t/ha). The fruits are characterized by high commercial and taste qualities (8.8-9.0 points) and an attractive appearance (the ‘Lastivka’ variety has a light blush, and the 2-14-22/05 hybrid has red fruits). The variety ‘Legenda of the Carpat’ stood out in terms of fruit size with an average weight of 323 g, the maximum – 408 g. Varieties and forms are characterized by resistance to scab (Venturia pirina), and ‘Legenda of the Carpat’ – to fruit rot (Monilia fructigena Pers.) and high resistance to bacteria (Erwinia amylovora Burill.). Key words: pear, hybrids, variety, selection, early fruiting, taste, stability, productivity.
Impact of climate change on fruit crops in the context of global research
Authors:   Institute of Horticulture of the National Academy of Agrarian Sciences of Ukraine, Bublyk M.O. , Hrynyk I.V. ,   Institute of Horticulture of the National Academy of Agrarian Sciences of Ukraine, Barabash L.O. ,   Institute of Horticulture of the National Academy of Agrarian Sciences of Ukraine, Chorna H.A. ,   Institute of Horticulture of the National Academy of Agrarian Sciences of Ukraine, Fryziuk L.A. ,   Institute of Horticulture of the National Academy of Agrarian Sciences of Ukraine
Published: March 2024

The purpose of this study was to analyze global achievements in the study of the direct and indirect effects of climate change on fruit plants, their phenology, yield, physiological responses to stress events, changes in pest insect populations, the spread of diseases, economic consequences, consumer habits, and outline directions for further research. The work methodology included searching and summarizing publications in popular scientific databases and journals. The analysis of scientific literature shows that temperature increase, water and temperature stress can cause a disorder in the development of plants and make important changes in the chemical composition of fruits and yield. Preserving the genetic diversity of plant species that have higher resistance to climate change is important for future breeding. Studies have also confirmed the complexity of the interaction of plants with the environment and their adaptation to abiotic stress. Physiological processes, such as photosynthesis and carbon distribution, under the influence of stressors can be manifested at different stages of plant growth, which is important for their reproductive processes. Further research into crop diversification strategies and effective land use practices to adapt to climate change are important aspects to be thoroughly explored. The development and implementation of new horticultural systems based on biotic intensification aims to ensure environmentally safe production and support. Ukraine, taking into account agro-industrial specialization, faces significant climatic risks, which can lead to serious consequences for agricultural production and the country's economy. Research results indicate the need for accelerated adaptation and development of effective measures to preserve natural resources and ensure sustainable development. Attention is drawn to the research of innovative approaches to the consumption of energy and food resources aimed at reducing gas emissions and improving environmental sustainability. Key words: weather factors, fruit crops, pests and diseases, phenology, stressful events, adaptation, genetic diversity, agriculture, economic consequences, consumer habits.
Aromatic plants as a source of biologically active substances with insecticidal, fungicidal and bactericidal effects
Authors:   Institute of Horticulture of the National Academy of Agrarian Sciences of Ukraine, Grynyk I.V. , Yezhov V.M. ,   Institute of Horticulture of the National Academy of Agrarian Sciences of Ukraine
Published: March 2024

The antioxidant action is inherent in the plant in its natural state and it is a manifestation of its reaction to the influence of biotic and abiotic factors affecting the plant disease process. The basis of these processes are natural mono- and diterpene compounds of plants, and more specifically essential oils of aromatic substances. They are somewhat inferior to synthetic analogues, but are much less dangerous. In general, almost all plant compounds are primary antioxidants, they react with reactive oxygen radicals (ROS) and stabilize their condition. The article presents the results of the assessment of the perspective of the essential oil of aromatic substances from plant raw materials against common diseases of insecticidal, fungicidal, and bactericidal action based on a comprehensive study (up to 100 types) of oil. It was established that thyme, rosemary, samosil, etc. have a significant bactericidal effect, almost at the level of the control - ambecillin. Such as mustard, rosemary, celery, etc. have an antifungal effect, some plants retain a significant insecticidal effect (common mosquito - catnip, sage; tick - fennel, mountain savory; mealybug - lofant hanus). The given results indicate the prospects of further joint use of both synthetic and natural preparations based on essential oils. Key words: diseases, synthetic drugs, essential oil, expediency of processing.
The declaration of adoptability situation at a crossroads
Authors: De la Torre Natalia
Published: March 2024

This paper investigates a topic that is booming in Argentine jurisprudence: the declaration of the adoptability situation of children based on the informed, thoughtful, and autonomous decision of their parents -generally women who decide not to exercise their maternity– to give their child for adoption considering the obligatory gender perspective, in line with the rights of children. With this objective as a goal, the regulation of the judicial declaration of the situation of adoptability and the autonomous decision to give a daughter or son for adoption is synthesized, the exception being that the declaration in a situation of adoptability is not appropriate if a referent of the family of origin or extended family is able to take care of the child and its complementarity with the best interest of the child. At the same time, the paths taken in Argentine jurisprudence regarding the birth of children after hindering the legal interruption of pregnancy are critically analyzed.
Revolución universitaria de Julio V. González
Authors: Ratto Alex E.
Published: March 2024

Este trabajo intenta explorar la construcción de una de las imágenes que se tiene sobre la Reforma Universitaria a poco tiempo de sus acontecimientos, una imagen que intenta potenciar el carácter revolucionario de los sucesos de Córdoba de 1918. Para ello, concentraremos nuestra atención en la producción de Julio V. González, unos de los protagonistas que postularon la necesidad de expandir el desconecto de una nueva generación de universitarios fuera del marco de la Universidad.

Hijo de Joaquín V. González, unos de los líderes modernista de la generación del 80, Julio V. González participó desde el inicio en la Reforma Universitaria. En 1919 se convirtió en el presidente más joven de la FUA. Y más tarde escribió trilogía donde teorizo sobre la reforma. Iniciada con La revolución universitaria de 1922, a la cual le siguieron La reforma universitaria de 1927) y La emancipación universitaria de 1929.

El objetivo de este trabajo es analizar la narración de Julio V. González de los hechos y principios de las Reforma del 18, en busca de encontrar sus particularidades. De esta forma, focalizaremos nuestro estudio en la interpretación de los antecedentes históricos de la Reforma señalados establecidos por él (advenimiento del radicalismo, I Guerra Mundial y la revolución rusa), como así también, de la valoración del uso de la violencia en su primer obra, La revolución universitaria de 1922.
Costo de producción y la fijación del precio
Authors: Barona López Norma Eulalia , Dota Moreta Angie Fernanda , Yánez Miranda Jenny Jadira
Published: March 2024

La investigación tuvo como objetivo general analizar la situación real de la empresa ADITEX enfocada en la producción de pantalones jeans, para la fijación de precios de la elaboración de jeans. La metodología utilizada fue un estudio de tipo de campo y nivel descriptivo, debido a que el investigador no manipula variables debido a que esto hace perder el ambiente de naturalidad en el cual se manifiesta y desenvuelve el hecho. Tras el análisis y resultados se evidencio que la empresa, necesita implementar un sistema de costos de producción para poder analizar y controlar las actividades y recursos técnicos y humanos involucrados en su proceso productivo. En conclusión, para que ADITEX pueda determinar la factibilidad de su empresa, es fundamental que implemente un sistema de costos de producción adecuado y que lleve un registro detallado de todos los costos involucrados en su proceso productivo.
Factibilidad para la inversión en un restaurante de comida
Authors: Vásquez Poveda Vanessa Dayana , Gutiérrez Lozada Valeria Karina , Freire Valverde Juan Francisco , Carrillo Rosero Diego Andrés
Published: March 2024

La investigación tuvo por objetivo determinar la factibilidad de mercado de una idea de inversión para estructura un proyecto de inversión en un restaurante temático orientado a familias con niños.  La investigación fue de nivel descriptivo y transeccional, la técnica utilizada fue la encuesta; la población estuvo conformada por habitantes de la ciudad de Ambato, Ecuador. Los resultados mostraron que la capacidad aprovechada se calculó a partir de la división de la capacidad real y la demanda proyectada, la misma reflejo como resultado el porcentaje de ocupación que en todos los productos está en un 85% para el año 1 y un 95% para el año 5, lo cual es factible y beneficioso. En conclusión, el proyecto es factible pues se establece un mercado meta de 29580.06 unidades, que equivale a una participación del 2% en el mercado que equivale a $177480.37.
El influjo psíquico como instrumento directo para la autoría mediata en el delito de cohecho
Authors: Albuja-Tintín Andrés Efraín , Cornejo-Aguiar José Sebastián , Castro-Sánchez Fernando-De-Jesús , Benavides-Salazar Cristian Fernando
Published: March 2024

El objetivo general de la investigación fue analizar jurídicamente el influjo psíquico como instrumento directo para la autoría mediata en el delito de cohecho. La presente investigación utilizó el método cuantitativo el cual produce datos descriptivos, que se originan por la recolección de datos. Apoyado en la revisión documental-bibliográfica. Conjuntamente, se aplicó el método inductivo-deductivo. Se planteó además el método analítico-sintético. Además, se realizó un cuestionario a 3 fiscales, 3 jueces de Garantías Penales y 3 académicos de Pichincha. Se concluye que, el influjo psíquico actúa como un instrumento directo para la autoría mediata en el delito de cohecho, en la actualidad esta influencia dada por razones de poder, jerarquía o abuso de poder ha generado el nacimiento de este nuevo delito que no se encuentra tipificado de manera taxativa en la normativa penal ecuatoriana.
La prueba pericial en los delitos ambientales y su incidencia en las sentencias judiciales
Authors: García-Ramos Eduardo Paúl , Cornejo-Aguiar José Sebastián , Castro-Sánchez Fernando-De-Jesús , Rojas-Calle Luis Adrián
Published: March 2024

El objetivo general de la investigación fue analizar jurídicamente la prueba pericial en los delitos ambientales y su incidencia en las sentencias judiciales. La presente investigación utilizó el método cuantitativo el cual produce datos descriptivos, que se originan por la recolección de datos. Apoyado en la revisión documental-bibliográfica. Conjuntamente, se aplicó el método inductivo-deductivo. Se planteó, además, el método analítico-sintético. Se concluye que, La falta de peritos especializados en materia ambiental dentro del sistema judicial del Consejo de la Judicatura en las distintas ramas del derecho ambiental, dificultando de esta manera el trabajo del titular de la acción penal como lo es fiscalía para que pueda demostrar los hechos antijuridicos que son cometidos en contra de la naturaleza.