bluuebunny/crossref_metadata_2025 huggingface dataset:
O uso de condimentos e especiarias como auxiliar no tratamento de adultos hipertensos: revisão integrativa da literatura
Authors: Siqueira Paese Márcia Carolina de , Magnabosco Patricia , Godoy Simone de , Marchi-Alves Leila Maria
Published: April 2023

Objetivo: analisar as evidências científicas disponíveis na literatura acerca dos principais condimentos e especiarias utilizados para auxiliar no tratamento de adultos com hipertensão. Método: estudo de revisão integrativa da literatura composto de etapas que visaram a identificação do tema, elaboração da questão de pesquisa, definição da amostra, categorização dos estudos, avaliação dos artigos incluídos, interpretação dos resultados e síntese do conhecimento. As buscas se deram no mês de agosto de 2022 nas bases PubMed, BVS, Embase e CINHAL, os descritores usados foram: “Hypertension OR Arterial Pressure” AND “Condiments” OR “Spices”. Resultados: foram identificados 1.725 estudos, com remoção de 149 artigos duplicados, 1.509 devido os critérios de exclusão, cinco devido à inacessibilidade na íntegra e 46 por não responder à questão norteadora. A amostra foi composta por 16 artigos, sendo a maioria publicado há menos de 10 anos. Foram observados três níveis de evidência (II, III e VI), onde 10 estudos eram ensaios clínicos (sete aleatórios e três não aleatórios) e seis eram observacionais. Conclusão: foram identificados estudos com resultados promissores em relação ao uso de condimentos e especiarias para o controle da pressão arterial; contudo, seriam necessárias outras investigações sobre a temática, com amostras representativas e capazes de fortalecer as recomendações de uso de tais substâncias para o controle da hipertensão.
Palavras-chave: hipertensão; pressão arterial; condimentos; especiarias; revisão
The Chemical Essence of life Antibiotics
Authors:   Reader, Dept of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, India, MR Arjun , Munir Sana ,   Final year student, Mahe Institute of Dental Sciences and Hospital, India
Published: April 2023

These are substances produced by microorganisms, which selectively suppress the growth of or kill other microorganisms at very low concentrations. This definition excludes other natural substances which also inhibit microorganisms but are produced by higher forms (e.g., antibodies) or even those produced by microbes but are needed in high concentrations (ethanol, lactic acid, H2 O2 ).
Avaliação de bebida alcoólica mista com substituição parcial de polpa por casca de abacaxi
Authors: Yamashita Dutra Caroline Sayuri , Camacho Batista Ana Clara , Rodrigues Alba Regina Pereira , Biancardi Oliveira de Medeiros Mabelle
Published: April 2023

O abacaxi, por ser amplamente cultivado, gera em sua industrialização uma grande quantidade de resíduos que poderiam ser utilizados para a obtenção de diversos outros produtos. Assim, o aproveitamento desses resíduos de abacaxi na obtenção de bebidas alcoólicas seria de grande interesse para as indústrias. A bebida alcoólica mista é obtida pela mistura de uma ou mais bebidas, com graduação alcoólica superior a meio e até cinquenta e quatro por cento em volume. Diante do exposto, o objetivo deste trabalho foi desenvolver formulações de bebida alcoólica mista de abacaxi substituindo polpa por casca. Foram elaboradas cinco formulações, tendo como variação a porcentagem de polpa e casca utilizadas, sem adição de aromatizantes, corantes e conservantes. Realizou-se análises físico-químicas de pH, acidez total titulável, °Brix, densidade relativa a 20°C, teor alcoólico, cor e análises microbiológicas. As formulações não apresentaram diferenças estatísticas significativas para o °Brix, pH, densidade relativa à 20ºC e teor alcoólico. Foi possível identificar a influência da substituição da polpa pela casca na análise de acidez total titulável. Já em relação à cor, apesar da variação proporcional com a adição de casca, a bebida se manteve com coloração característica de produtos de abacaxi. Na avaliação de aceitação visual, todas as formulações foram consideradas bem aceitas pelo consumidor. A bebida também despertou o interesse do consumidor, onde, em pesquisa, 70% dos entrevistados, afirmaram que comprariam a bebida, sendo as formulações 1 e 2 as que apresentaram as maiores médias de intenção de compra.
The Polysemous Lexemes in the Kazakh Dictionary Written in Cyrillic of the XIX Century
Authors:   L.N. Gumilyov Eurasian National University, Kadirova M.S. , Yusupova A.Sh. ,   Kazan Federal University
Published: April 2023

In modern Turkological science, it is relevant to study the language of Turkic written legacies written by various graphic systems as Runic, Uighur, Arabic, Latin, Cyrillic. In this context, Kazakh legacies written in Cyrillic at the end of the XIX – early XX century have not been sufficiently studied to date. The article examines how the Turkic peoples, including Kazakhs, adopted Cyrillic script around the turn of the nineteenth and twentieth centuries, when the first Cyrillic Kazakh ABC books, self-help books, dictionaries, and other landmarks were published by P.M. Melioransky, N.I. Ilminsky, M.A. Terentyev, V.V. Katarinsky, L. Budagov, and others. I. Altynsarin, A. Baitursynov, T. Bokin, Zh. Kusherbayev, M. Mashanov, and others were among the Kazakh intellectuals who actively started using the Cyrillic alphabet at that time as the enlighteners of the nation. Among Cyrillic publications bilingual dictionaries held a unique position, providing a glimpse into the Kazakhs' way of life during a particular historical period. Due to the fact that they contained both linguistic and ethno-cultural knowledge. The article is devoted to one such dictionary, in particular the «Kyrgyz-Russian Dictionary», which was released in 1897 in Orenburg by B.A. Breslin's publishing company. The unnamed dictionary was created using N.I. Ilminsky's dictionary, «Materials for the study of the Kyrgyz dialect» (Kazan, 1861) that was expanded upon and amended with the help of the Kazakh intellectuals. The article examines the polysemy of these dictionary's words. The polysemous meanings of this dictionary are exposed, together with their lexical and semantic variations, on the basis of the notions of polysemy. This also reveals the continuity of this dictionary polysemous meanings with the lexemes of the contemporary Kazakh language.
Correcting the 2019 survey abundance of Bering-Chukchi-Beaufort Seas bowhead whales for disturbance from powered skiffs
Authors: Givens Geof
Published: April 2023

The 2019 ice-based survey of Bering-Chukchi-Beaufort Seas bowhead whales was challenged by missed survey effort, unusual ice conditions, and frequent use of motor-powered skiffs by hunters. All three of these likely led to downward bias in the abundance estimate of Givens et al. (2021). Data were collected about boat excursions during the survey period. Indices of short-term whale abundance at the survey perch and short-term boat noise disturbance were computed from the available data, where ‘short term’ refers to a few hours. A generalized additive model (GAM) was fit to the results, predicting short-term whale abundance as a smooth function of the boat noise disturbance index, after controlling for long-term variation in the whale passage rate over the course of the season. The fitted GAM was then used to predict passage with and without the presence of boat noise. The ratio of the integrals of these two predicted passage curves provided a correction factor which can be applied post hoc to the abundance estimate of Givens et al. (2021). Variance of this correction factor was estimated using two approaches, and found to be small. A wide array of sensitivity analyses was conducted to examine the robustness of the result to potential changes in methodology, and the correction factor was found to be quite stable. The estimated correction factor would inflate the original abundance estimate by about 12%, yielding a corrected abundance of 14,025 (CV=0.228). We recommend that this replace the original abundance estimate.
Organochlorine contaminants in cetaceans: how to facilitate interpretation and avoid errors when comparing datasets
Authors: Krahn Margaret M. , Ylitalo Gina M. , Stein John E. , Aguilar Alex , Borrell Asuncion
Published: April 2023

This paper reviews current scientific literature to provide information for avoiding errors commonly made in comparing and interpreting datasets from laboratories measuring organochlorine contaminants in cetaceans. Before making comparisons and interpretations using heterogeneous datasets (e.g. those from different laboratories or those from different methods in the same laboratory), it is essential to consider specific information about the animals sampled (e.g. age, sex, reproductive status, body condition and health status), sampling procedures (e.g. necropsy of subsistence, stranded or bycaught individuals; remote or surgical biopsy), methods for measuring and conventions for expressing analytical results for lipids and contaminants (e.g. percent lipid, percent dry weight, contaminant concentration units, totals of contaminant groups such as PCB congeners) and quality assurance performance. Reformatting should be carried out, as necessary, to unify the datasets (e.g. into like units and weight basis) and allow a critical evaluation of the data to be made. As part of the data interpretation, caveats or limits in the comparability of the datasets (based on quality assurance results) should be provided. In addition, the biological relevance of the data must be considered in interpreting the datasets.
Sex hormone concentrations in the blood of sei whales (Balaenoptera borealis) off Iceland
Authors: Kjeld M. , Vikingsson G. A. , Alfredsson A. , Olafsson O. , Arnason A.
Published: April 2023

Blood samples were collected postmortem at sea, from 195 sei whales (127 females and 68 males) caught southwest of Iceland between 1983 and 1988. The reproductive status of the whales was determined by anatomical/histological methods. The blood samples were measured by radioimmunoassays for progesterone (P), testosterone (T) and oestradiol concentrations, which were then related to the reproductive status, the length of the whales and the days of the hunting season. Serum P concentrations in females were found to be clustered mainly into two groups, one with values at or below the detection limit (0.1nmol/L) of the assay (Group I) and the other with values about two orders of magnitude higher (Group III) with intermediate values (Group II) in between. Anatomical results showed that Group I (n = 73) was largely a mixture of immature and anoestrous mature females. Group III (n = 39), with a significantly (p < 0.01) greater mean body length than Group I, had a distinct frequency distribution of serum P values with a mean (SD) concentration of 10.3nmol/L (4.1) and consisted predominantly of pregnant females. Many foetuses were lost at sea due to a slit in the abdomen for cooling purposes, but all 13 foetuses (1.5-3.7m in length) recovered belonged to females of Group III. Group II (n = 15) consisted mainly of anoestrous mature animals. When pregnancy was estimated by serum P values and sexual maturity by the anatomical findings, the apparent pregnancy rate of mature females was 0.37, agreeing reasonably with earlier reports. Male sei whales were classified into immature, pubertal and mature groups by anatomical/histological methods and had mean T concentrations (nmol/L, ranges) of 0.85, 0.1-4.5; 3.3, 0.1-14.7 and 4.8, 0.1-14.8, respectively. Serum T concentrations did not correlate significantly with body length in the groups but pubertal and mature males had significantly higher geometric mean T values than immature males. Mean serum T concentrations in males, classified as sexually mature by anatomical/histological methods, rose approximately 3.2-fold every 30 days during July-September indicating a seasonal breeding cycle. It is concluded that measurements of sex hormone concentrations in sei whales make a powerful addition to the earlier anatomical/histological methods for determination of reproductive status, not only corroborating them but apparently surpassing them in sensitivity of detecting pregnancy and cyclical changes in serum T values during the male reproductive cycle.
Distribution of small cetaceans within a candidate Special Area of Conservation; implications for management
Authors: Hastie Gordon D. , Barton Tim R. , Grellier Kate , Hammond Philip S. , Swift Rene J. , Thompson Paul M. , Wilson Ben
Published: April 2023

Information on cetacean distribution plays an important role in the identification of suitable boundaries for marine protected areas, but is also crucial for developing management and monitoring programmes. In response to the European ‘Habitats Directive’, a candidate Special Area of Conservation (cSAC) has been established in the Moray Firth, northeast Scotland to protect a small and isolated population of common bottlenose dolphins (Tursiops truncatus). Limited data on the distribution of bottlenose dolphins and on temporal changes in distribution have recently constrained attempts to mitigate against the impacts of new developments upon this population. In response to the need for current information on the distribution of dolphins throughout the cSAC, this study aims to provide data on the distribution of dolphins and other small cetaceans throughout the Moray Firth. Changes in the distribution patterns of dolphins in the inner Moray Firth were examined using data collected between 1990 and 2000. In addition, combined passive acoustic and visual survey techniques were used to determine the distribution of dolphins and harbour porpoises (Phocoena phocoena) on a broader scale across the whole Moray Firth. Dolphin schools were distributed throughout the inner Moray Firth, but there were concentrations of sightings around three deep, narrow channels that were consistent over the ten year study period. Results from surveys across the whole of the Moray Firth showed that all sightings and acoustic detections of dolphins were made within the area of the cSAC. In contrast, porpoise sightings were widely distributed throughout the Moray Firth. The median encounter rate of porpoises across the whole Moray Firth was 1.69 per 100km. Encounter rates of porpoises were similar in the outer Moray Firth and the cSAC. This combination of distribution studies at differing spatial scales provides a valuable tool for monitoring the distribution of animals and identifying important habitats, and the results of this study have directly supported efforts to manage the cSAC.
Modern Prejudice in Everyday Interactions
Authors: Yoon Youngwon , Zong Kristina Sooyoun
Published: April 2023

Social status diversifies experiences. From personal achievements to interpersonal interactions, the disparity is often forged by individuals either deliberately or indeliberately. Regardless of the purpose, such actions entail stereotypes, ultimately reinforcing discrimination. This research aims at exploring a potential route through which status privilege socially pervades and solidifies: the perceptions of and consequent reactions to different occupations. Undergraduate students in South Korea participated in the study. First, participants read three chronologically invented scripts, conceiving of themselves as interacting with fictitious characters with either an upper- or a lower-status occupation. Next, they imagined their tentative attitudes as well as expectations of each character. Analyses revealed that participants reacted more favorably to the upper-status characters in the two of the three interactions. Furthermore, these characters were expected to be significantly more competent and intelligent than those with a lower-status occupation. Together, the findings spotlight one type of modern prejudice that may influence not only everyday communications but important decision-making processes.
Evaluating the United States Minimum Legal Drinking Age: A Medical Review
Authors: Jung Sehyun , Doty Chad
Published: April 2023

The Minimum Legal Drinking Age of 21 (MLDA-21) has been a source of contentious debate, enduring over a century of ethical and medical justifications. Critics cite the neurological and behavioral consequences of adolescent alcohol consumption to argue for the maintenance or even an increase from MLDA-21. Advocacy groups even propose mandatory training for adolescents in order to reduce harmful binge-drinking behavior. On the other hand, proponents of lowering the age limit argue that, ethically and politically, MLDA  must match the threshold of legal adulthood. They also claim that there are some scientific basis for lowering MLDA. However, this study that analyzed a wide breadth of scientific sources found that medical consensus validates MLDA-21. Studies find that the harms of adolescent alcohol consumption, including mental disorders, behavioral complications, and developmental consequences, outweigh the benefits of making alcohol more legally accessible.
A comparison of the effects of melatonin and bisphenol A on the behavior of motile zooxanthellae
Authors: Jones Austin , Martinez Lynell , Garrido Lisa
Published: April 2023

Bisphenol A (BPA) is classified as an organic chemical pollutant and has received global concern due to its widespread presence in the world’s ocean at relevant environmental concentrations as well as its various negative toxicological and reproductive effects. Endocrine disruption suggests that BPA may compete with hormone receptors involved in cell communication.

Melatonin is an indoleamine produced by many cnidarian species as well as some dinoflagellates. It is a natural neurotransmitter involved in processes such as movement, sexual maturation, metamorphosis, and reproduction.

Research by Ann Tarrant and others suggest that both substances play a role in cell signaling and communication and could be influencing the symbiosis between corals and zooxanthellae. It also proposes that melatonin and BPA share a competitive relationship in vertebrates, with melatonin lowering rates of BPA-induced proliferation of breast cancer cells.

This study aimed to examine the roles and relationships of BPA and melatonin in zooxanthellae, to better understand cell signaling and behavior in dinoflagellates, and explore the similarities and differences in these processes to other marine invertebrates as well as terrestrial vertebrates.

It found negative behavior in zooxanthellae at 100 parts per million BPA and determined that the endocrine-like signal transduction in some dinoflagellates and vertebrates is alike because melatonin and BPA share a competitive relationship in both. It is possible that BPA could be interfering with inter- and intraspecies signaling in marine organisms. Because of these findings, the presence of BPA in high concentrations in the ocean could be devastating to the world’s coral reefs.
Applying Machine Learning Techniques to Mitigate Impact of COVID-19 Pandemic
Authors: Krishna Sidarth , Appavu Rajagopal , Kethar Jothsna
Published: April 2023

Since March 2020, COVID-19 has played a very influential role in our lives. Totaling over 300 million cases and 5.5 million deaths worldwide it has been one of the most transmittal viruses humans have seen in recent generations. Even after the mass distribution of vaccines, COVID-19 shows no signs of stopping. This is because many communities that are especially struggling during this time period have not been identified and are not being helped adequately enough. By better understanding how different factors in communities such as ethnic percentages, poverty rates and much more can help us determine which communities need to be addressed to slow the spread of COVID-19. To identify the most significant of these demographic factors an in depth data analysis using machine learning models and regression analysis were carried out on various datasets. The results highlighted that for COVID-19 cases the most influential factor was Population Density. For deaths, the most significant factors were poverty rates in communities as well as education level. From this analysis and results, in order to mitigate the impact of the COVID-19 pandemic in the future it is of utmost importance to address the needs of underprivileged communities by providing access to low cost and high quality medical resources for all.
MUSICOTERAPIA, ENFERMAGEM E SAÚDE MENTAL NO TRANSTORNO DO ESPECTRO AUTISTA: UMA REVISÃO INTEGRATIVA
Authors: Sousa Stefhani Medeiros de , Carneiro Eduardo Cipriano , De Brito Joyce Maria Portela , Fernandes Lidiane Luzia de Araújo , Eloia Suzana Mara Cordeiro , Ferreira Heraldo Simões
Published: April 2023

O autismo é definido com uma condição em que existe um prejuízo na interação social, alterações na comunicação e padrões limitados ou estereotipados de comportamentos e interesses. Nesse sentido, utilizam-se as práticas integrativas e complementares para proporcionar melhor atendimento, dentre estas, a musicoterapia, pela facilidade de poder ser aplicada pela equipe multidisciplinar em diversos ambientes, e que promove o vínculo profissional-cliente, além de poder incluir o cuidador nessa rotina. O presente estudo tem como objetivo analisar as evidências disponíveis na literatura sobre a utilização da musicoterapia aplicada ao Transtorno do Espectro Autista (TEA). Trata-se de uma pesquisa do tipo revisão integrativa, com busca nas bases de dados científicas, PUBMED, LILACS e SCIELO, sendo artigos de interesse musical dentro de atividades terapêuticas e que fosse aplicado a pacientes com TEA. Utilizou-se o total de 12 artigos que apresentaram como resultados que, dentre os instrumentos disponíveis para a terapia, como o ruído branco e objetos de percussão, a música se sobressai como escolha preferencial de intervenção com resultados satisfatórios, melhorando a expressão, o comportamento, a interação social e, consequentemente, a qualidade de vida. Por fim, é perceptível que a música tem o poder de atingir a psique humana, mudando o humor, mesmo que indiretamente, praticando terapia sem ao menos perceber e sua autonomia, que dá um passo de confiança às pessoas que sofrem com TEA.
Biodegradation of Expanded and Extruded Polystyrene with Different Diets by Using Zophobas atratus Larvae (Coleoptera: Tenebrionidae)
Authors: Hoe Tay Jun , Asib Norhayu , Abd Aziz Nor Azwady , Hun Tan Geok
Published: April 2023

Polystyrene waste pollutes the environment and poses a significant health risk to humans, animals, and marine ecology. This study aims to evaluate the effectiveness of degradation on expanded (EPS) and extruded (XPS) polystyrene with different diets using superworms (Zophobas atratus larvae) obtained in Malaysia. The growth and development of the larvae after consumption of EPS and XPS and the gut microbial community changes in response to high polystyrene consumption diets were also identified. The oatmeal, wheat bran, and cornmeal were used as supplement diets and showed significantly enhanced EPS and XPS consumption and degradation compared to sole diet treatment. Gel permeation chromatography was carried out using egested frass of Z. atratus larvae to characterize depolymerization of EPS and XPS, indicating a significant reduction in the average molecular weight and average molecular weight. The highest reduction occurred in the presence of oatmeal. Proton nuclear magnetic resonance and Fourier transform infrared spectroscopy analyses indicated functional group changes and chemical modification occurred with depolymerization and partial oxidation of EPS and XPS. The larvae length increased, while the number of instars and duration of larvae became shorter with the addition of supplement diets. Oatmeal is predominantly effective among other supplements in assisting Z. atratus larvae with EPS and XPS degradation. The results of this study support the ubiquity of polystyrene biodegradation in Z. atratus and the next-generation sequencing studies. Kluyvera sp., Klebsiella sp., and Enterobacter sp. were found to be strongly associated with degrading EPS and XPS polystyrene with oatmeal as a supplemental diet.
Structural Development of Marine Green Alga (Ulva rigida C. Agardh, 1823) during Cultivation
Authors: Paopun Yupadee , Thanomchat Piyanan , Roopkham Chanram , Umroong Patcharee , Pan-utai Wanida , Satmalee Prajongwate , Kosawatpat Prapat , Thongdang Bussaba , Tamtin Montakan
Published: April 2023

Ulva rigida C. Agardh (sea lettuce) is a marine green alga. It grows naturally near shorelines in areas with freshwater influence. It can also be cultivated easily on farms and can be developed into many healthy food products, which bring in revenue for Thailand. It is important to develop an effective way to cultivate the alga. In this research, the molecular biology of sea lettuce using the tufA gene for the identification of Ulva genus and morphological characters at different culturing periods of U. rigida thallus were investigated using a light microscope (LM), a scanning electron microscope (SEM) and a transmission electron microscope (TEM). The results revealed that the U. rigida alga consisted of various cell shapes including elliptic, irregular triangle, irregular quadrilateral, pentagonal and polygonal. The cell size increased with increasing periods of culture. However, when the alga was cultured for 28 days, the cell sizes were smaller than the original cells due to cell division during aging, resulting in an increase in cell numbers. U. rigida had grown rapidly in 14 days which was a relatively short period of cultivation. The results of this study indicate that U. rigida has a potential to be scaled up in pilot and commercial scales.
HIGHLIGHTS

The molecular analysis of sea lettuce from Phetchaburi Coastal Aquaculture Research and Development Center, Sub District: Bang Kaeo, District: Ban Laem at Phetchaburi Province, Thailand was found to be rigida
The morphological and anatomical characters of rigida thalli were studied with light microscope, transmission electron microscope and scanning electron microscope techniques
The cell sizes of rigida thalli changed with culturing days. They were the largest at 14 days in the surface view, and at 14 and 21 days in the transverse section

GRAPHICAL ABSTRACT
A Study on the Performances of AI Recruitment System: A Case Study on Domestic and Abroad Companies
Authors:   The Korean Career·Entrepreneurship & Business Association, Son Seungwon , Oh Juyeon
Published: April 2023

This study examines how AI technology is being used in the recruitment process through domestic and international case studies of AI recruitment systems such as Google, Softbank, Unilever, Amazon, Loreal, Samsung, Lotte, SK, KB Kookmin Bank, Hyundai and LG, and seeks to verify the introduction performance of AI recruitment systems, and presents matters to be considered when companies select AI recruitment systems. AI Recruitment system improves the time efficiency, work efficiency, objectivity and accuracy of the recruitment process, allows a wider pool of applicants, and provides more fair opportunities for evaluation to candidates. Despite these effect, the following points should be considered when companies want to introduce AI Recruitment system. 1) AI HRM cannot guarantee positive results for all companies, 2) and companies should have personnel managers who are in charge of AI Recruitment system and a system to apply Recruitment, 3) In addition, the purpose of introducing AI Recruitment system should be established. 4) Also, It should be recognized in advance that the application of AI Recruitment system may show unintended consequences such as prejudice, 5) AI Recruitment system cannot replace everything in the realm of human beings, 6) Finally, since it takes a long time to implement AI Recruitment system in order to examine its effectiveness, companies should review the need for AI Recruitment system as well as cost.
The Effects of Worker’s Job Value, Job Instability, and Work-life Unbalance to Entrepreneurial Intention: Focusing on the Mediated Effects of Entrepreneurial Attitudes
Authors:   The Korean Career·Entrepreneurship & Business Association, Ha Kyusoo
Published: April 2023

This study seeks to verify Because of the uncertainties of companies, job instability is increasing, work-life styles are rapidly changing, and the meaning of job values are also changing. This study focused on the dynamic relationships among those factors: job values of employees. job-instability, entrepreneurial attitudes, and entrepreneurial intentions of employees. The data were collected from the employees of diverse companies. The analysis was conducted by SPSS Win 24 version. The results of this study were as follows. First, among the job-values, economic factors and self-fulfillment positively affected on entrepreneurial intention. Second, the jon-instability of employees positively affected entrepreneurial intention. Third, the unbalance of work-life of employees positively affected entrepreneurial intention. Fourth, the entrepreneurial attitudes positive positively affect on the entrepreneurial intention. This research will contributes on the studies of work values, job-unstability and entrepreneurial intentions and entrepreneurial activities.
Heart Failure with Preserved Ejection Fraction: Management Guidelines (From Heart Failure Association of India, Endorsed by Association of Physicians of India)
Authors: S Harikrishnan , Oomman Abraham , Jadhav Uday M , Raghuraman Bagirath , Mohanan PP , Tiwaskar Mangesh , Wander GS , Chopra VK
Published: April 2023

Heart failure with preserved ejection fraction (HFpEF) accounts for 15–20% of patients with heart failure (HF) in India. Diagnosis is by clinical features supported by biomarkers and echocardiography. Lifestyle modifications, control of risk factors to optimum levels, and treatment of comorbidities are essential in the management of HFpEF. Spironolactone and sacubitril-valsartan [angiotensin receptor neprilysin inhibitor (ARNI)] are beneficial in subsets of HFpEF, especially with lower range of ejection fraction (EF). Sodium-glucose co-transporter-2 inhibitors (SGLT2i)—empagliflozin and dapagliflozin and probably sotagliflozin are the only currently available drugs which have shown benefits in HFpEF, mostly by reducing hospitalizations. The benefit of SGLT2i is evident in both diabetic and nondiabetic subsets.
Iron Deficiency Anemia as a Potential Risk Factor for Unprovoked DVT in Young Patients: A Case Series
Authors: Yadav Khushbu , Yadav Varuna , L Margekar Shubha , Bansal Priya , Aggarwal Ramesh , Gupta Ankit , Ghotekar L H
Published: April 2023

Deep vein thrombosis (DVT) is a serious and potentially life-threatening condition due to the occurrence of pulmonary embolism (PEs) in the acute phase. DVT can be provoked or unprovoked. Provoked DVT can be associated with transient or persistent causes. Iron deficiency anemia (IDA) with reactive thrombocytosis can act as a prothrombotic condition. We present two case reports of lower limb DVT which was associated with moderate anemia. Association between IDA and thrombosis has been reviewed.
Post-COVID Syndrome: The Stranger Ghost of Culprit COVID-19
Authors: Bhandari Sudhir , Rankawat Govind , Joshi Shashank , Tiwaskar Mangesh , lohmror Anurag , Bhandari Shiven
Published: April 2023

Background: Post-COVID syndromes are the most abundant sequel of coronavirus disease of 2019 (COVID-19) infection, which affects millions of people around the whole world. There is a significant difference observed during the acute phase as well as during the post-COVID period between patients hospitalized with (alpha, delta, or omicron) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant. In the present scenario, when most people are vaccinated, COVID-19 disease is less likely, but the remnants of previous COVID-19 infections are still a vast health burden. Materials and methods: This prospective, observational, comparative, and analytical study included a total of 3,840 COVID-19-infected patients who visited the hospital. We included 1,150 patients of alpha variants, 1,845 patients of delta variants, and 815 patients of omicron variants, from June 2020 to November 2020, March 2021 to July 2021, and January 2022 to May 2022, respectively. All medical data of the study population, including hospital stay and vaccination status, were collected, and all patients were followed up for 6 months of duration. All collected data were compiled and analyzed to compare the post-COVID thrombotic and other events among different variants of COVID-19. Results: Patients infected during the delta variant are the most symptomatic at onset (higher prevalence of fever, dyspnea, cough, myalgia, headache, or gastrointestinal problems) than those infected with the alpha or omicron variant (p < 0.01). A total of 2,830 patients (7.48%) [1,520 (82.38%) of delta variant, 598 (73.37%) of omicron variant, and 712 (60.34%) of omicron variant] developed post-COVID syndrome during their follow-up period out of 3,220 enrolled patients and the difference was statistically significant when compared among variants (p < 0.05). In this study, the highly prevalent post-COVID syndrome was mucormycosis (11.41%), followed by new-onset diabetes (9.89%), pulmonary fibrosis (7.67%), ischemic heart disease (6.46%), brain stroke (3.29%), and other thromboembolic disorders (2.37%). Conclusion: COVID-19-associated onset symptoms during the delta variant were more severe and highly prevalent, while neurological symptoms (aguesia and anosmia) were more common during the alpha variant. Patients infected with the delta variant of COVID-19 are more prone to develop post-COVID-associated complications with minimal risk in the omicron variant and intermediate risk in the alpha variant. Long COVID-19 requires specific attention for management, irrespective of the SARS-CoV-2 variant.
Atypical Multiple Myeloma Case: Atypical Clinical Presentation, in Female and at Young Age
Authors: G Surnar Sachin , H Tare Kaustubh , M Bhosikar Abhijeet , S Desale Sushant , Nasikkar Nikhil S
Published: April 2023

Background: Multiple myeloma (MM) is ranked as the 14th most prevalent cancer, making up 1.8% of all cancers and 10% of blood cancers, rarely seen below 35 years. MM presented aggressively in the young age group, including greater incidences of extramedullary plasmacytomas, plasma cell leukemia (11%), osteolytic lesions, kidney failure (25%), and Bence Jones proteinuria (81%). Though youngsters have an aggressive presentation, their response to treatment is as similar to older patients. Case: We reported a case of a young female from the rural Konkan region of Maharashtra with complaints of right limb radicular pain and back pain diagnosed with MM with acute kidney injury and hypercalcemia. First-line treatment for her included conventional chemotherapy mixed with a proteasome inhibitor (bortezomib) and intravenous hydration for acute kidney injury and hypercalcemia with injection (inj) zoledronate. Conclusion: The case study shows how MM must be ruled out before being considered as a possible diagnosis for a young child who has neurological problems and mass lesions.
Antropologia, Educação Física e Saúde Coletiva: aproximações interdisciplinares
Authors: Ferreira Jaqueline , Silva Alan Camargo , Souza Mayara Cassimira de
Published: April 2023

O presente trabalho visa abordar as aproximações entre Antropologia e Educação Física que se encontram na formação em Saúde coletiva. Nesse aspecto a interdisciplinaridade é essencial para a renovação de temáticas e incorporação de novos conceitos. O ponto de confluência dessas áreas é o estudo do corpo e da saúde. O corpo interessa a essas áreas não somente por seus aspectos biológicos e intervenções biomédicas, mas por ser uma expressão de sentimentos, discursos e práticas emblemáticos de processos sociais. Essa discussão intenta  contribuir para a formação acadêmica e práxis da Saúde Coletiva sobre os cuidados relativos à saúde corporal.
Pain Experiences of People Diagnosed With Autism Spectrum Disorder: A Systematic Review of Case–Control Studies
Authors: Ortiz Rubio Araceli , de María Romero Ayuso Dulce Nombre , Torres Sánchez Irene , Cabrera Martos Irene , Rodríguez Torres Janet , López López Laura , Valenza Marie Carmen
Published: April 2023

Importance: Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental disorders and is characterized by compromised social interactions, reduced verbal communication, stereotyped repetitive behaviors, restricted interests, and sensory abnormalities. Yet absent from the knowledge base is information about sensory abnormalities related to pain experiences. Exploring the pain experiences of people with ASD may provide occupational therapy practitioners with a baseline to determine areas of need and effective interventions.

Objective: To conduct a systematic review of the literature to summarize current evidence from case–control studies comparing sensory abnormalities with regard to pain experiences of people diagnosed and not diagnosed with ASD.

Data Sources: A systematic literature search of the CINAHL, Cochrane, MEDLINE (PubMed), OTseeker, and Web of Science databases, using MeSH terms and broad keywords.

Study Selection and Data Collection: A search was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Newcastle–Ottawa Scale was used to evaluate the risk of bias of the included studies.

Findings: A total of 27 case–control studies involving 865 people with ASD and 864 control participants were included. Several methods were used to explore pain experiences, such as threshold detection or pain threshold.

Conclusion and Relevance: The results indicate that people with ASD may have an abnormal sensory experience with regard to pain sensitivity. Occupational therapy practitioners should develop an intervention to focus on pain.

What This Article Adds: This study adds to the body of literature indicating that people with ASD have sensory abnormalities with regard to pain experiences. Results highlight the need for occupational therapy interventions to focus on pain experiences.
Reductions in Depression and Anxiety Among Autistic Adults Participating in an Intervention to Promote Healthy Relationships
Authors: Holmes Laura Graham , Goebel Russell J. , Hollingue Calliope , Zhu Shuning , Zhang Handing , Shan Wuji , Wang Shicong , Caplan Reid , Sanchez Amelia , Wharmby Peter , Chiang Melody , Person Mariah , Rothman Emily F.
Published: April 2023

Importance: Some autistic adults experience depression and anxiety related to their social relationships. There is a need for evidence-based occupational therapy interventions that decrease depression and anxiety and improve the health of social relationships for autistic adults.

Objective: To determine the feasibility and preliminary effectiveness of the Healthy Relationships on the Autism Spectrum (HEARTS) intervention, a six-session, group-based psychoeducational intervention for the improvement of relationship health.

Design: One-group pretest–posttest design with a 3-mo follow-up after baseline.

Setting: United States; online intervention through community organization.

Participants: Fifty-five adults, ages 20 to 43 yr, with a professional or self-diagnosis of autism and the capacity to independently participate in an online, group-based, participatory class.

Intervention: Participants received 6 90-min weekly sessions that addressed healthy relationship topics, including recognizing abuse, meeting people, maintaining relationships, setting interpersonal boundaries, neurohealth for relationships, and ending relationships. A psychoeducational approach that provided education and involved guided discovery and strategy acquisition was used.

Outcomes and Measures: All measures were self-administered through an online survey. Depression and anxiety were assessed using instruments from the Patient-Reported Outcomes Measurement Information System.

Results: Fifty-five participants completed the intervention. Postintervention scores revealed statistically significant improvements in depression and anxiety.

Conclusions and Relevance: HEARTS is a promising intervention for improving depression and anxiety among autistic adults and should be investigated further.

What This Article Adds: HEARTS offers a potentially effective, nonpharmacological, psychoeducational group-based intervention option to promote healthy relationships for autistic adults.

Positionality Statement: This article uses identity-first language (autistic person) in accordance with the preference of autistic self-advocates (Autistic Self Advocacy Network, 2020; Kenny et al., 2016; Lord et al., 2022).
Pernod Ricard will mit weniger Alkohol wachsen
Authors: Brück Mario
Published: April 2023

Pernod Ricard reagiert mit weniger Alkoholgehalt auf Verbraucherwünsche. Positiver Nebeneffekt: Mit sinkenden Prozenten steigen die Margen.
Pepsi verordnet sich neuen visuellen Auftritt
Authors: Saal Marco
Published: April 2023

In den USA hat Coca-Cola auf dem Softdrink-Markt gegenüber dem ewigen Konkurrenten Pepsi noch immer klar die Nase vorne. Dagegen will PepsiCo jetzt angehen. Die Wende soll ein neuer Markenauftritt bringen.
Wenn die Lieferkette rasselt
Authors: Pionke Stefanie
Published: April 2023

Frankfurt a.M. Das Lieferkettengesetz betrifft immer mehr Unternehmen. Banken richten ihre Finanzierung zunehmend nachhaltig aus. Der Druck auf Landwirte wächst.
Food-Innovations-Update
Authors: Deininger Olaf
Published: April 2023

Frankfurt a.M. Hier der monatliche Überblick der aktuellen Projekte und Aktivitäten der Food Labs und Food Hubs.
SmartYoutuber: A Data-driven Analytical Platform to Improve the Subscriber Growth and Sustainability using Artificial Intelligence and Big Data Analysis
Authors: Li Muyang , Serbicki Erik , Sun Yu
Published: April 2023

Youtuber is a new type of freelancer, whose economic profit and personal reputation are highly decided by their own popularity on the Internet, which can be reflected directly by the number of subscribers accumulated. In order to develop the management of YouTube channels and get more advertisement benefits, youtubers need to maintain the current subscriber group and appeal to more new followers by making attractive videos. But they lack efficient methods to analyze their video quality and their communication with subscribers so that they can predict their future development and adjust present strategies. In this paper, we applied several machine learning algorithm and models to study the prediction of short and long term future subscriber increase (we call them as growth and sustainability of youtubers) by analyzing youtuber-related information including video content(e.g. topic type, video tags, etc.) and subscriber interaction(e.g. views, likes, comments, etc.). One highest-scoring regression algorithm is proposed to make the out-performing prediction for certain youtubers, and we have proven its rationality and high accuracy in predicting the growth and sustainability of YouTube subscribers with suitable configuration. Apart from establishing algorithms, a relevant website, which offers services for future prediction and improvement suggestions, is created based on the established random forest regression algorithm. This application allows youtubers to completely analyze their current management situation and assists them to increase popularity for both social and economic benefits.
De-Biasing Rating Propensityalgorithmin Group Recommendation
Authors: Jia Junjie , Shang Tianyue , Chen Si
Published: April 2023

In recent years, group recommendation systems have gradually attracted attentionwith the increasingphenomenon of people's group activities.Nonetheless, most research focuses on optimizing machine learning models to fit user behavior databetter.However, user behavior data is observational rather than experimental. Due to the different psychological benchmarks of user ratings, the training data evaluated by the algorithm cannot fully represent the real preferences of the target group. A De-Biasing Rating Propensity Algorithmin group recommendation is proposed. The proposed algorithmidentifies user groups with similar behavior preferences through the Predict & AHC algorithm based on cosine similarity, and calculates user bias information by groupand user preference tendency for different user groups. The De-Biasing Proportionon different items is used to build a rating bias consistency model, which effectively adjusts the user's predicted rating.The experimental results show that the algorithm can significantly improve the quality and fairness of recommendation.
An Application that Combines Learning and Games to Make Learners Keep Interested in Learning
Authors: Zhang Larry , Sun Yu
Published: April 2023

Learning a new language and a new culture is always fun and interesting at the beginning. However, when learners get deeper into the learning process, they find that whether it is memorizing vocabulary, learning dif erent types of grammar, or learning a new culture that is completely dif erent from the learner's country, it becomes very dif icult and learners gradually lose their enthusiasm for learning. Also, some of the textbooks right now are published a long time ago. Teaching some 20 or 30 years ago’s culture won't help the learner and may make them misunderstand the modern culture of that country. So, why can't we give the learner more accurate information and keep the learning process as fun as ever? This paper designs a software that combines the games and learning together. By setting up dif erent scenarios, building a variety of representative buildings, adding various characters to communicate with, designing dif erent culturally significant objects, and conceiving an interesting story plot to let people who are learning a new language or culture can learn in a unique and more fun way. After applying the app to language schools, Japanese language learner communities, and the Internet, the results showed that the app makes learners learn in a more relaxed atmosphere and makes them want to learn more.
MVMNET: Graph Classification Pooling Method with Maximum Variance Mapping
Authors: Wang Lingang , Sun Lei
Published: April 2023

Graph Neural Networks (GNNs) have been shown to effectively model graph-structured data for tasks such as graph node classification, link prediction, and graph classification. The graph pooling method is an indispensable structure in the graph neural network model. The traditional graph neural network pooling methods all employ downsampling or node aggregating to reduce graph nodes. However, these methods do not fully consider spatial distribution of nodes of different classes of graphs, and making it difficult to distinguish the class of graphs with spatial locations close to each other. To solve such problems, this article proposes a Maximum Variance graph feature Multistructure graph classification method (MVM), which extracts graph information from the perspective of graph nodes feature and graph topology. From the nodes feature perspective, we enlarge the variance between different classes while maintaining the variance between the same class of data. Then the hierarchical graph convolution and pooling are performed from a topological perspective and combined with a CNN readout mechanism to preserve more graph information to obtain a graph-level representation with strong discrimination. Experiments demonstrate that our method outperforms several number of state-of-the-art graph classification methods on multiple publicly available datasets.