bluuebunny/crossref_metadata_2025 huggingface dataset:
Inhibition Test of Browning Reaction in Apple (Malus domestica Borkh.) by Low NaCl Concentration
Authors: Yusuf Maulana , Legowo Anang Mohamad , Al-Baarri Ahmad Ni'matullah
Published: May 2019

Reaction of enzymatic browning in fruit is a reaction that occurs due to the oxidation of phenol and involves the enzyme polyphenol oxidase (PPO). Prevention of browning reactions can be done by inhibiting PPO activity, one of alternative is to use NaCl. The purpose of this study was to determine the ability of low NaCl concentration to inhibit the browning reaction based on the color change of L* value. Apple peels was dipped in phosphate buffer pH 7.0 containing 0.1 M NaCl and incubated at room temperature for 6 hours. The result indicated the hindrance of NaCl in the development browning color that was detected by L* value. In conclusion, NaCl may inhibit the process of browning apple in room temperature.
The legal regulation of genomic DNA banks in the context of social, cultural and regulatory diversity
Authors: Przhilenskiy V. I. , Vergun A. A.
Published: May 2019

The article deals with the normative regulation of genetic research and bioengineering, compares the experience of different countries in this area. The author subjects a legislative framework for the preservation of privacy in the formation of biobanks in such countries as Denmark, Israel and China to a detailed analysis. On the example of law enforcement practice in the States mentioned above, the author shows the variety of ways of development of relevant legislation, as well as the impact of legal, political and socio-cultural traditions on those ways. Special attention is paid to the connection of genetic research with the development of computer technologies that require complex legal regulation with due regard to specifics of genomic and computer knowledge. The author substantiates relevance of the thesis about a decisive role of the influence of political and administrative reasons in choosing the strategy of legislative and institutional regulation of biotechnology and bioengineering by means of a comparative review of various schemes and models emerging in Danish, Israeli and Chinese legal reality. In the article, the authors shift from the problem of development of legal support of genomic biobanks to the problem of ethical foundations of this activity, and expand the angle of view by considering protection of rights of unborn children, protection of rights of minors and those who have lost their legal capacity due to old age. The authors systematize and problematize the issues of preserving effectiveness of legal regulation in the development of precision (personalized) medicine that is based on the ontology of the unique, while law enforcement, in principle, is normative, and, therefore, based on the ontology of the universal.
Opportunities and directions for digital economy development in Russia and blocking factors of its development
Authors: Petrov A. A.
Published: May 2019

The paper shows the importance of the 4th Industrial Revolution and its product — the digital economy — in the development of mankind, its dual impact on the welfare and labor market of a specific people, the country, as well as the world community as a whole. The author examines the consequences of introduction of artificial intelligence, cyberphysical systems in production processes. Also, the paper analyzes the German program “Industry 4.0” shifting a German manufacturing industry on a digital basis through the use of digital technologies and setting up smart factories. The author summarizes the digital programs of the USA, Great Britain, Japan. The possibilities and problems of development and blocking of digital economy in Russia are shown. The author describes such basic components of the digital economy as blockchain, cyberphysical systems, digitalization, big data, artificial intelligence. He considers adverse consequences of the digital economy, factors blocking its development, as well as possible ways of their neutralization and elimination.
Anti-corruption monitoring in public administration
Authors: Polyakov M. M.
Published: May 2019

The paper deals with the concept, essence and purpose of anti-corruption monitoring in public administration. The author carries out a comprehensive analysis of the main directions of anti-corruption monitoring exercised by the relevant officials of state bodies. The paper examines provisions of normative legal acts at the Federal level and at the level of constituent entities of the Russian Federation that envisage the order of anticorruption monitoring, as well as the powers of participants of this direction of combating corruption in public administration. The author gives examples of reporting documents of anti-corruption monitoring of some public authorities and gives his own assessment of their content. The author substantiates the proposals for amendments and additions to the federal anti-corruption legislation in order to consolidate anti-corruption monitoring as one of the most important tools to combat corruption.
Unilateral organizing transactions (transactions concerning organization of relations between the parties): problems of definition and interpretation in the context of joint use of goods and services (sharing economy)
Authors: Poduzova E. B.
Published: May 2019

A modern social and economic context of joint consumption (sharing economy) raises new questions about the use of structures of organizing contractual relations, in particular unilateral organizing transactions. The article presents the main doctrinal problems of unilateral transactions, as well as unilateral organizing transactions. The author examines approaches to the classification and classification groups of unilateral transactions, and highlights the constitutive features of unilateral organizing transactions. The paper considers the legal nature of a unilaterally binding and unilaterally enabling transactions, sets out the legal relationship between these groups of transactions. Constitutive features of unilateral organizing transactions form the basis for qualification of transactions that are most often considered in the doctrine as unilateral organizing transactions. Thus, the author defines the legal nature of issuing powers of attorney, testamentary refusal, offer, acceptance, registration applications for improvement of living conditions, etc. Methodologically, the article is based on the main results of the reform of contract law of the Russian Federation, new trends in the science of civil law. Also, the author scrutinizes the classical civil law doctrine on unilateral transactions, organizing contracts and organizational relations.
Historical aspect of the development of the institution of subject matter jurisdiction in civil proceedings
Authors: Polushkin E. S.
Published: May 2019

The author conducts a retrospective analysis of the institution of subject matter jurisdiction in Russian civil proceedings. The institution of subject matter jurisdiction originates in the pre-revolutionary period. To determine the mechanism of delimitation of competence between jurisdictional bodies, such concepts as “exclusive jurisdiction” or “establishment” were used. During this period, a distinction was made between the competence of administrative and judicial bodies.

The concept of “subject matter jurisdiction” was enshrined in Soviet legislation for the first time ever. Moreover, in the scientific literature, subject matter jurisdiction is often identified with court jurisdiction. The main task of subject matter jurisdiction in the Soviet period was the division of competence between the courts of general jurisdiction and state arbitration. During this period, the subject and object criteria for delimitation of competence between the courts of general jurisdiction and other jurisdictional bodies, which are currently used, were formulated.

In the post-Soviet period, the judiciary was finally separated from the executive and the courts acquired particular significance in resolving jurisdictional disputes. All large categories of cases were transferred to the jurisdiction of the judiciary. The creation of a system of arbitration courts has led to an even greater importance of the institution of subject matter jurisdiction. It was in the post-Soviet period that the categories of “subject matter jurisdiction” and “court jurisdiction” were finally delimited. As a result of the study, the author concludes that there is some continuity in the development of the institution of subject matter jurisdiction.
Application by courts of judgments of the constitutional court of the russian federation and the European Court of Human Rights in one case
Authors: Chaykina A. V.
Published: May 2019

The paper deals with the problem of the application by the courts of the Russian Federation of decisions of the Constitutional Court of the Russian Federation and the European Court of Human Rights in the same civil case. The problem is caused by the uncertainty of the hierarchy of these sources of law in terms of international and national law. The issue of non-fulfillment of ECtHR judgments was considered from the point of view of the provisions of the Vienna Convention on the Law of Treaties of 1969. The author analyzes foreign practice on the execution of judgments of the ECHR. In particular, the author analyzes the practice of the United Kingdom and the Federal Republic of Germany, having faced with the contradiction of the fundamental norms of the state with the ECtHR judgments.

The mechanisms to balance the legal positions of these courts have been revealed. The author suggests considering Protocol No. 16 to the Convention for the Protection of Human Rights and Fundamental Freedoms as one of the possible means to eliminate the contradictions between the Constitutional Court of the Russian Federation and the ECHR. The procedure of advisory opinions, from the point of view of the author, may make it possible to coordinate the legal positions of the ECHR and the national practice of applying the Rome Convention to the stage of submitting a complaint of Russian citizens to the ECHR.
Reflections of Asabiyyah Effect on Social Differentiation in Social Media: The Case of the July 15th Military Coup Attempt
Authors: MENCET Mustafa Sami , ERTÜRK Onur
Published: May 2019

During the July 15th Coup Attempt in Turkey, many firsts were experienced. The Grand National Assemblyof Turkey and other state buildings were bombed by Turkish warplanes led by putschist pilots, the civilianswere fusilladed intensively and their resistance was strong and uncompromising. Yet, the media subordinateto the putschists in previous coup attempts played a crucial role in the failure of the putschists in this coupattempt. Just after the President’s call to civilians for resistance in the squares, many people, who wereorganized in the social media platforms, shielded themselves against soldiers and tanks immediately, butthe soldiers of junta could manage to kill 173 civilians. Meanwhile, another part of the society kept theirsilence and went to ATMs or markets in fear of a probable war. When the activities in the social mediawithin the process of the coup attempt are considered, it can be figured out that both parts of the societywere influenced by the social media contents and that they acted accordingly. An in-depth analysis ofthe elements that affect the perception, and reactions within these two different segments of the society,attitude-development and action-taking of these two parts is vital for the prevention of such attempts whichhave the power to directly influence the well-being of the country and the peace of the society. For thispurpose, in this study, social media activities and the reactance of the masses pre – and intra-coup attemptare analyzed. Two hashtags and two visual contents representing the different reflections of the processof the 15th of July Coup Attempt in the social media are analyzed through Roland Barthes’s SemiologicalDenotation/Connotation Model, and the role of the media in the assumption of different attitudes of themasses are examined by scrutinizing the different attitudes of both pro – and against-government parties and the collective actions through the Asabiyyah theory of Ibn Khaldun. Findings summarizes factorsthat are threating the social peace and reinforcing discrimination; and furthermore, they show why it isimportant to adopt the Asabiyyah theory to understand such social events.
Lugares para el bautismo, reformas y modernidad en los decenios centrales del siglo XX
Authors: Longhi Andrea
Published: May 2019

El bautismo constituye el sacramento más compartido entre las diversas confesiones cristianas, pero al mismo tiempo, presenta histórica y geográficamente una diversificación casi ilimitada de formalizaciones litúrgicas y soluciones espaciales. Estas diferencias no se corresponden, sin embargo, de modo unívoco con las diferencias entre las diversas confesiones, pero atraviesan la arquitectura litúrgica en un modo transconfesional, según declinaciones culturales y sociales, no solo rituales.Esta comunicación propone una lectura del debate sobre el lugar del bautismo en los decenios centrales del siglo XX, comparando las prácticas bautismales más difundidas entre las denominaciones protestantes con los experimentos católicos realizados en el periodo del Concilio Vaticano II. Se discutirá la hipótesis de si las prácticas bautismales católicas de los años sesenta y setenta son deudoras de la tradición protestante. En síntesis, el lugar del bautismo puede ser considerado —con la aparición de las diversas reformas, tanto en el siglo XVI como en el XX— un extraordinario catalizador de experiencias, sensibles a la dimensión popular del cristianismo en todas sus confesiones.
CYP1A2 Gene Polymorphism and Theophylline Level in Asthma
Authors: Lorensia Amelia , Ikawati Zullies , Andayani Tri Murti , Maranatha Daniel , Wahyudi Mariana
Published: May 2019

BACKGROUND: Aminophylline (theophylline) is one of the most frequent asthma therapies in Indonesia, although it remains as a narrow therapy. The effects of drugs are individualized and strongly influenced by genetic, one of which is CYP1A2 gene polymorphisms. This study aimed to determine the profile of CYP1A2 polymorphism and theophylline level in asthma exacerbation patients receiving intravenous aminophylline therapy.METHODS: This cross sectional study was conducted in the emergency room (ER), to adults asthma exacerbation patients without complication (n=27), visiting the ER. The gene polymorphism data were compared with theophylline levels in the blood using chi-square test.RESULTS: In the CYP1A2 gene polymorphism profile, the most common heterozygous alleles are T/G genotype of CYP1A2*1E and C/A genotype of CYP1A2*1F. Most homozygote alleles exist in CYP1A2*1D and CYP1A2*1F. There was significant difference between CYP1A2*1D (p<0.005), CYP1A2*1E (p<0.023) and CYP1A2*1F (p<0.000) polymorphisms and theophylline level.CONCLUSION: CYP1A2*1D, CYP1A2*1E and CYP1A2*1F gene polymorphisms had an effect on theophylline levels. However, no one experienced an overdose theophylline, and no correlation between theophylline levels with CYP1A2 gene polymorphism.KEYWORDS: exacerbation asthma, intravenous aminophylline, CYP1A2 polymorphism gene, theophylline
Bir devlet hastanesi acil servisinde kırık tanısı alan hastaların değerlendirilmesi
Authors: PAMUK Çağdaş
Published: May 2019

Amaç:
Kırık olguları günümüzde aktif yaşamın artmasıyla
birlikte giderek artış göstermektedir. Bu çalışmada Kars Harakani Devlet
Hastanesinde kırık tanısı almış hastaların, demografik özelliklerini ve nasıl
tedavi edildiklerini değerlendirmeyi amaçladık.Gereç
ve Yöntemler: Veriler Haziran2016-Kasım
2018 tarihleri arasında Kars Harakani Devlet Hastanesi kayıt sisteminden
retrospektif olarak elde edildi.
Hastaların yaş, cinsiyet, travmanın şekli, tanısı ve hastaya uygulanan
tedaviler tespit edildi. Tüm veriler SPSS version 13 programında analiz edildi.Bulgular:
Çalışmaya alınan hastalarının
489’u (%81,6) erkektir, yaş ortalaması 35,6±29,4’dür.
Ayaktan tedavi edilen hastaların %12,8’ine nöbetçi acil uzmanı müdahale
etmiştir. Yatış yapılan 469 hastanın yatırıldığı servise göre dağılımı
incelendiğinde 337’si (%71,8) ortopedi servisine yatırılmıştır. Ortopedi yatışı
yapılan hastaların %11,3’ünü (n:53) 
radius-ulna kırıkları oluşturmaktadır. Ortopedi servisine yatırılan
hastaların 272’sine (%80,7) cerrahi tedavi, 65’ine (%19,2) konservatif tedavi
uygulanmıştır.

Sonuç: Sonuç
olarak acil serviste kırık tanısı alan hastaların önemli bir kısmının, ortopedi
kliniği tarafından değerlendirildiği ve önemli bir kısmının güncel ortopedik
literatüre göre cerrahi olarak tedavi edildiği akılda tutulmalıdır.
Safe Childbirth: A Call to Action
Authors: Lothian Judith A.
Published: May 2019

Since the publication of Lamaze's Six Healthy Birth Practice papers in 2014, there has been increasing concern with the safety of the current maternity care system. A doubling of the maternal mortality rate in the United States and the continued high cesarean rate, as well as ongoing research that supports physiologic birth and identifies the risks of interfering with the physiologic process, has resulted in updated guidelines for care and has spurred advocacy efforts to transform maternity care. This article presents a number of these advocacy efforts.
REVIEW ON THE MANUAL OF V. V.KHOKHLOV “FORENSIC MEDICINE” (4th edition, in 3 volumes)
Authors: Klevno V. A.
Published: May 2019

Dr. Sci. (Med.), professor V. A. Klevno gave a review on the 4th edition of the manual by V. V. Khokhlov “Forensic medicine” issued by Moscow publishing house “Yurayt” in 2019 (series “Professional practice”, in 3 volumes).
Bookshelf tour
Authors: Sundström Admeire da Silva Santos , Moraes João Batista Ernesto de
Published: May 2019

Existem diversas formas de se organizar o conhecimento e isso torna viável e necessário o estudo de instâncias populares de organização do conhecimento. Nesta pesquisa, o objeto de estudo é a comunidade booktube, que é composta por pessoas que dividem suas experiências literárias através de vídeos disponibilizados na plataforma YouTube. As análises dos vídeos permitiram classificar determinados booktubers como colecionadores de livros. Entende-se que o colecionismo bibliográfico ocorre em instância particular, é motivado por razões subjetivas e a organização desses acervos segue ordens próprias de cada colecionador, sendo assim, questiona-se: é possível aplicar a concepção de folksonomia para identificar as categorias de organização do conhecimento da comunidade booktube? O método é composto por duas etapas: a primeira, consiste na construção do aporte teórico, que buscou a definição conceitual dos assuntos relevantes para análise e interpretação dos dados. A partir disso, parte-se para a segunda etapa, que consiste no uso do Discurso do Sujeito Coletivo para extração dos termos utilizados pela comunidade em questão. Como resultado, percebeu-se a presença de categorias de organizações, a possibilidade do uso do Discurso do Sujeito Coletivo para categorização da linguagem natural e a memória coletiva implícita nesse sistema. Por fim, percebe-se a possibilidade de se utilizar a concepção de folksonomia para identificar modos de organização no colecionismo, os prós e os contras da linguagem natural em uma estrutura conceitual e a possibilidade de se interpretar a folksonomia em outros ambientes além da atual abordagem de processo ou produto de tagueamento na web 2.0.
Preservação digital na gestão de processos administrativos de uma instituição de ensino superior: o caso dos PEAPDs da PROGEP da UFSM
Authors: Oliveira Siqueira Schuch Crislei Daiana , Saad Denise de Souza , Flores Daniel
Published: May 2019

Sabe-se que a evolução das tecnologias da informação foi acompanhada pelo aumento de sua importância para as organizações. Assim, este estudo buscou propor um modelo de gestão de preservação digital, em longo prazo, dos processos administrativos de exercícios anteriores de Progressão Docente da Pró-Reitoria de Gestão de Pessoas da Universidade Federal de Santa Maria, para viabilizar que esses processos possam, no futuro, ser criados em formato digital e preservados em repositórios arquivísticos digitais confiáveis. Para tanto, foi realizada uma pesquisa de natureza aplicada, com abordagem quali-quantitativa. No tocante aos objetivos, pesquisa descritiva. Os resultados demonstraram que o objetivo foi cumprido, na medida em que foi desenvolvido o Modelo de Gestão de Preservação Digital, adaptado para manter a cadeia de custódia e a autenticidade dos documentos dos Processos de Exercícios Anteriores de Progressão Docente. No futuro, os documentos poderão ser produzidos nato digitais no Sistema de Informações para o Ensino. Palavras-chave: Preservação digital. Documento arquivístico digital. Autenticidade. Tecnologia de Informação e Comunicação. UFSM.
Museus e justiça de transição no contexto brasileiro: memória e informação na construção de espaços de representação do trauma
Authors: Hoffman Felipe Eleutério , Frota Maria Guiomar da Cunha
Published: May 2019

Por todo o globo, acontecimentos como o Holocausto, o Apartheid, o Onze de Setembro, e os períodos ditatoriais na América Latina, têm gerado uma obrigação de se prestar contas ao passado, principalmente através de uma necessidade de marcar a época com a criação de lugares de memória. O surgimento de museus e memoriais que lidam com as memórias da repressão e resistência nos contextos ditatoriais dos países latino americanos do Cone Sul acompanha este contexto global em que se observa a criação de um número crescente de instituições de informação e memória que adotam as causas locais com relação aos direitos humanos como questão principal de sua missão institucional. O presente ensaio objetiva analisar o surgimento de instituições museais em contextos de justiça transicional com foco por sobre a realidade brasileira. São delineados alguns dos aspectos centrais que envolvem o estabelecimento destas instituições, bem como algumas das problemáticas implicadas. Nesta direção, traz um panorama e apresenta algumas destas iniciativas em âmbito nacional. É observado que no que tange o contexto brasileiro, as medidas que caracterizam o campo da justiça transicional possuem estágios diferenciados de implementação em cada uma de suas dimensões e, de maneira geral, diferentes autores reconhecem que muitas medidas são consideradas tardias em relação a outros países da América Latina.
Patients and Caregivers’ Understanding of Pressure Injury Risk Factors and Their Participation in Care
Authors: Ilesanmi Rose Ekama , Olayinka Bolaji Funke , Hanson Victoria Funmilayo
Published: May 2019

Background: Recommendations to prevent pressure injuries (PI) consistently emphasize patients’ participation in care, without which interventions are less likely to be effective. Aim: To examine patients and/or their caregivers’ knowledge of risk factors and participation in PI preventive interventions.Subjects and Methods: This descriptive study was conducted among 70 patients in neurological and orthopaedic wards in the University College Hospital in Nigeria. The patients were purposively selected. Knowledge about risk factors for PI, level of participation in care and perceived barriers were examined using structured questionnaire.Findings: Mean age was age 49± 18years; 37(66.1%) did not consider they were at risk for PI. Poor knowledge of risk factors: incontinence (59.3%), dragging self out of bed (56.5%), loss of sensation (58.3), when the nurse drags than lifts (66.7%) was found. Mean knowledge of risk factors was 1.42±0.49 and level of participation (1.31± 0.47). Barriers to participation included inadequate instruction from nurses about what they or their caregivers needed to do (2.41±1.16); pain during repositioning (3.58±1.16); feeling incompetent to turn (3.10±1.27; caregivers not allowed to stay on the ward (3.47±1.12). Only education was significantly associated with level of participation (P= 0.002< 0.05). However, no significant association existed between the medical diagnosis of the patients and their level of participation (P = 0.347 >0.05). Conclusion: Patients’ knowledge of risk factors was poor and participation was also low. Well defined instructions should be provided during hospitalization to improve patient’s participation in care.
EFL Teacher’s Oral Questioning: Are Her Questions and Strategies Effective?
Authors: Milawati Milawati , Suryati Nunung
Published: May 2019

Evidence is mounting that teacher question can assist EFL students in various purposes in teaching learning process. However, teacher’s lack of knowledge about questioning taxonomy could become a failure in leading students’ learning. This study investigates questioning strategies, the taxonomy of questions-type, and their application by teacher in advanced prose class, to scaffold students’ learning. Classroom observations, field notes and videotape recording, were employed to collect the data. Findings indicate that among four types of questioning strategies, redirecting was the most frequently used to initiate students’ responses and to probe more into students’ understanding. Other findings show that low-cognitive questions were common. Of those, knowledge-based questions were the most frequently used to confirm students’ understanding of the materials they learnt, but, the higher-level questions were rarely used. It was also found that teacher employed questioning strategies ineffectively to manage the class; insufficient time responded to a complex level of questions; the number of questions created confusion. Some changes to create effective classroom questioning and a stronger connection between the level of question and the questioning strategies are discussed.
Fast 4D Geomechanical Modeling with Multiple Applications
Authors: Renli Lasse , Helstrup Ole Anders , Ke Ganpan , Thompson Nicholas
Published: May 2019

A fit for purpose 4D Geomechanical model is regarded valuable for most fields. Although tools for building such models have been available for some time they are commonly not made or not fully utilized due to the extensive amount of time, complexity and costs involved. In Equinor a workflow (DE4RM) has been developed for fast 4D geomechanical modeling, effective visualization and interpretation. Using this workflow, models have been built for more than 20 fields over the last 4 years and results applied for a variety of areas including input to seismic time shift analysis, short and long term well planning, estimation of cooling effects from injectors, subsidence/compaction predictions, input to well completion, monitoring optimization, overburden integrity studies, out of zone injection and fault re-activation assessment. Some examples on such use will be given in this paper. On the modeling side key factors for efficient modeling are utilization of existing reservoir models, use of commercial finite element software and a streamlined, easy to use, workflow for all pre-processing steps. Particularly, a well-equipped toolbox for various grid-editing functionality has been essential for being able to complete the modeling fast enough (1-3 weeks). Once a model is built it is readily available for both geomechanical experts and non-specialists through the open source powerful visualization platform Resinsight. In this software geomechanical capabilities have been developed over the last years guided by practical use of the models. Further development on both the modeling, visualization and post-processing side is ongoing and as Resinsight is open source, use of the software and development of new functionality is possible for anyone. In summary, 4D geomechanical modeling and utilization of such models has become a daily activity in Equinor for numerous applications, gradually replacing simplified 1-D based methods with the faster and more accurate DE4RM methodology.
Comparative Study of Surface and Downhole Drillstring Vibrations Measurements on a Laboratory-Scale Drilling Rig
Authors: Wiktorski Ekaterina , Geekiyanage Suranga , Løken Erik , Sui Dan
Published: May 2019

Drillstring vibrations are a dynamic response of the drillstring to a combination of external forces and initial conditions. Such response is can be measured and recorded by various sensors that are mounted into rigs’ hoisting or rotating systems or directly along the drillstring. Most commonly, the sensors measure dynamic displacements and accelerations and are located either at the surface or downhole. Indisputably, the downhole measurements carry more useful information about the drillstring dyamics than the surface ones, because they are located closer to the vibration sources, like forces from rock-bit interaction, side forces and other mechanical forces. However, in certain cases, for instance, when the transmission capacity is low, serious transmission delay happens or no downhole signal is available, we have to rely on the surface readings, such as torque and RPM (rotational speed), WOB (weight on bit) and SPP (stand-pipe pressure) to monitor the drilling operations.

In this study, we use a small-scale drilling rig, equipped with surface sensors to monitor the dynamics of the drillstring under various conditions as rotation and application of instantaneous force. In addition, a high-speed camera is used to capture downhole dynamics. The study focuses on comparing the sensors’ data, which is achieved by analyzing the key parameters that describe periodic oscillations of the drillstring: frequency, amplitude and damping ratio.

High-speed cameras represent a non-invasive method for detecting and recording displacements, which can be integrated into the rigs’ real-time measurement system. It has been proved to provide accurate and practically noise-free measurements, thus it can be applied as a surface motion detection sensor in various well operations and as a downhole sensor in laboratory conditions for proof-of-concept approaches.

The conducted analysis reveals that the sensors respond differently to the applied load depending on their type and location even in the case of a small-scale experimental rig. This paper provides meaningful interpretation of the measured data and a way to extract the most valuable information from both surface and downhole sensors to enhance the understanding of the drillstring dynamics during drilling operations.
The Impact of Production Logging Tool Data PLT on Scale Squeeze Lifetime and Management of Scale Risk in Norwegian Subsea Production Wells – A Case Study
Authors: Jordan Myles
Published: May 2019

Due to the higher cost of scale management for subsea compared to platform or onshore fields, and because of the more limited opportunities for interventions, it is becoming increasingly important to obtain and utilise real production data from wells rather than estimated zone flow contribution from simple permeability (K) and height (h) models for scale squeeze treatment design.

This paper discusses how scale squeeze treatments were designed (coreflood evaluation of inhibitor retention/release) and deployed for three subsea heterogenous production wells. A permeability and layer height model were initially developed for each well based on detailed geological log data, estimated water/oil production rates and predicted water ingress location within the wells. Two of wells were each treated three times via bullhead scale squeeze treatments with effective scale control being reported over the designed lifetime. Prior to the fourth squeeze campaign of these two wells a production log was carried out and this information incorporated into the squeeze simulation to allow review of the ongoing third squeeze and enhance design accuracy for the upcoming fourth squeezes. A third well was treated twice before production logging data became available and the performance of treatments to this well is also assessed.

The production log data (PLT) proved very important in changing the understanding of fluid placement and location of water ingress during production resulting in changes to the isotherm values used to achieve effective history match to the inhibitor returns (with PLT data incorporated in all three wells) and most significantly impacting the squeeze lifetimes. Two of the treated wells were able to be significantly extended in their treatment lifetime (cumulative produced water to minimum inhibitor concentration) while the treatment life of one well was greatly reduced due to the PLT modified model predictions.

The paper outlines the process of reservoir/near wellbore modelling that is utilised for most initial squeeze treatments service companies deploy in the North Sea. It will highlight in detail the value that PLT data can provide to improve the effectiveness of the squeeze treatments in terms of understanding of fluid placement during squeeze deployment and water ingress location within heterogenous production wells. The intention of the paper is to highlight the value this type of data can provide to improve scale management (squeeze treatment and water shutoff) such that the value created more than offsets the cost of acquiring such information for subsea production wells.
A randomized controlled trial on the effect of remote ischemic preconditioning on ERK1, ERK2, STAT3 and STAT 5 in patients with and without diabetes mellitus undergoing CABG surgery
Authors: Brevoord Daniel , Smit Kirsten F. , Wang Yimming , Hollmann Markus W. , Kerindongo Raphaella P. , Weber Nina C. , Preckel Benedikt
Published: May 2019

Background Remote ischemic preconditioning (RIPC) is less effective in patients with diabetes, and the molecular mechanisms behind this lack of protection are not fully understood. In this study we investigated the effects of remote ischemic preconditioning on the intracellular signal cascade (known as the RISK pathway), e.g. ERK1/2, STAT3 and STAT5 in patients with and without diabetes undergoing coronary artery bypass graft (CABG) surgery. Methods Twenty-six patients with and 24 patients without diabetes mellitus undergoing CABG surgery under a total-intravenous, propofol based anesthetics regime, were randomized to either remote ischemic preconditioning induced by 3x 5 minutes of forearm ischemia or untreated controls. In each patient, two atrial tissue samples were collected: the first before, and the second after preconditioning, but before initiation of cardiopulmonary bypass. Tissue samples were homogenized and the ratio of total-to-phosphorylated ERK1 and 2, STAT 3 and STAT5 were determined by Western Blotting. Myocardial injury after CABG was assessed by analyzing postoperative troponin release. Results In the patients without diabetes, no effect of RIPC on any of the molecular markers was observed. In addition, we found no reduction in postoperative peak troponin release after RIPC. In patients with diabetes, ERK1 and ERK2 phosphorylation was increased in the control group, while in the RIPC treated patients only ERK2 was significantly increased. STAT3 phosphorylation was increased in both, the control and RIPC group, while there was no effect on STAT5 phosphorylation. Again, there was no effect on postoperative troponin release. Discussion We found no effect of RIPC on ERK 1, ERK2, STAT 3 or STAT 5 in either patients with or without diabetes. Additionally, there was no reduction in troponin T release by RIPC. The major limitation of our trial is the small sample size. Trial registration The trial was prospectively registered in the Dutch trial register as NTR1931.
Theme trends in research related to retinal vein occlusion: a quantitative and co-word analysis
Authors: Liu Fei , Chen Ximei , Zhao Miao
Published: May 2019

Background. This study focused on plotting knowledge structure and exploring research hotspots of retinal vein occlusion (RVO).
Methods. In this study, research articles, with subject of RVO, were acquired from PubMed. Bibliographic Item Co-Occurrence Matrix Builder (BICOMB) was used for MeSH terms acquisition, evaluation and high-frequency MeSH term determination. Biclustering analysis and knowledge structure were conducted based on the MeSH term-source article matrix. RVO theme trends were illustrated with social network analysis (SNA), along with strategic diagrams.
Results. A total of 3179 articles on RVO were retrieved, and the annual research output increased with time. USA ranked first with the most publications, with Retina as the most prolific journal in RVO research. MeSH terms were characterized into five different genres. As shown by the strategic diagram, the complications of RVO, the etiology of macular edema, as well as the therapeutic use of anti-VEGF, steroids and anti-inflammatory agents were well developed (Quadrant I). In contrast, epidemiology, metabolism and genetics related research on RVO were relatively immature (Quadrant III). Research on surgical treatments of vitrectomy, diagnostic methods and pathology of RVO were centralized but undeveloped (Quadrant IV). The SNA results was exhibited by the centrality chart, on which the node position was represented by the centrality values.
Conclusions. By providing a bibliometric research, the overall RVO research trends could be revealed based on the five categories identified by this study. The mathematical bibliometric study could shed light on new perspectives for researchers.
Biological proprieties of Pasteurella multocida isolate from sheep in Morocco
Authors: Boumart zineb , Bamouh Zahra , Jazouli Mohammed , Rafie Lamya , Tadlaoui Khalid Omari , Harrak Mehdi EL
Published: May 2019

Background
In Morocco, observations of pasteurellosis clinical cases reported by field veterinarian and lesions observed in abattoirs, suggest circulation of serotypes of pasteurellosis among small ruminants population. However, little is known on the prevalence of the main serotypes in this region and their pathogenicity.
Results
We investigated five suspected Pasteurella clinical cases from different provinces of Morocco. We succeeded to isolate 2 strains (S14 and S13) of Pasteurella Multocida A among the five isolates. Identification was achieved by biochemical and molecular biology methods. Phylogeny based on two genes sequence analysis (RNA16S and rpoB) suggested that the two isolates present similarity with others from different species. A pathogenicity study was conducted in mice, guinea pigs and sheep to set up a model for vaccine testing. The strain S14 was more virulent than S13 in laboratory animals and induced severe illness in sheep.

Conclusion
The high mortality of infected mice suggest that this animal may represent a good alternative for testing pathogenicity and vaccine efficacy.
Assessment of financial performance and the effect on dividend policy of the banking companies listed on the Indonesia Stock Exchange
Authors: Puspitaningtyas Zarah
Published: May 2019

This study aims to determine the assessment of financial performance and the effect on dividend policy of banking companies listed on the Indonesia Stock Exchange in the period of 2014–2017. The assessment of the company’s financial performance is important. Results of the assessment will be consideration of financial performance for investors, one of them to predict the dividend policy. The prediction results will influence investors in making investment decisions. This study employs a quantitative approach. The assessment of financial performance is measured using variables of leverage, profitability and profit growth. They were analyzed using the multiple linear regression method. At the 0.05 significance level, the results of this study showed that the leverage has a negative and significant effect on dividend policy. Meanwhile, profitability and profit growth have no effect on dividend policy. In order to explain the influence between variables, the research is based on the theories underlying the dividend policy, namely the theory of residual dividends and smoothing theory. The results of this study support the residual dividend theory, that one of the dividend policies is determined by the company by considering the target capital structure and then distributing dividends with only the remaining profit.
Optimization of a service it company’s business processes functional structure
Authors: Yatsenko Roman , Balykov Oleksii
Published: May 2019

The paper proposes an approach to optimizing the functional structure of the business processes of a service IT company based on the business process management system as an active self-organized, viable system that takes into account the peculiarities of the information technology industry development. This allows to optimize the structure of business processes through adequate positioning and formal description of the whole set of complex hierarchical interconnections with the aim of transition from hierarchical to functional structure of enterprise’s business processes taking into consideration the relationships between elements. The designed business process management system is considered as a set of strategic, tactical and operational business processes that are interrelated within a single strategic goal. The graph of the functional tasks of the investigated service IT company is formed, which reflects the incidence and closeness of the links between business processes. The model of optimization of the functional structure of business processes is proposed based on the algorithm, which involves minimizing the total connections of the subsets of the vertices of the functional graph, with the help of which the optimal restructured system of business processes was constructed, which increases the efficiency of management of the investigated service IT company. The advantages and disadvantages of the restructured functional structure of the service IT company’s business processes were analyzed. It is determined that the restructuring of the business process system will be effective only with changes in the enterprise processes management based on appropriate management strategies.
Giant pseudoaneurysm of aorta and aortobronchial fistula after surgery for aortic re-coarctation
Authors: Kornilov I. A. , Sinelnikov Yu. S. , Soynov I. A. , Ivantsov S. M. , Nichay N. R. , Omelchenko A. Yu. , Gorbatykh Yu. N. , Voitov A. N.
Published: May 2019

Aortobronchial fistula is a rare but potentially fatal complication after balloon plasty of aortic coarctation. We present a case of successful single-stage correction of giant pseudoaneurysm of the aortic arch with aortobronchial fistula in a 6-year-old patient after aortic arch replacement, which developed as a result of avulsion of the synthetic graft from the aortic wall when performing balloon angioplasty of a narrowed part of the aorta.

 

Received 15 April 2015. Accepted 30 April 2015.

 
Efficacy and safety of bioresorbable vascular scaffold Absorb: 6-month outcomes of GABI-R: Russia registry
Authors: Prokhorikhin A. , Fartakov E. , Malaev D. , Boykov A. , Oidup-Ool S. , Baystrukov V. , Grazhdankin I. , Zubarev D. , Pokushalov E. , Kretov E.
Published: May 2019

Aim. The paper demonstrates the interim analysis of efficacy and safety after everolimus-eluting bioresorbable vascular scaffold (BVS) Absorb implantation in “real-world patients” with coronary artery disease.Methods. A cohort of 500 consecutive patients who underwent percutaneous coronary intervention for stable chest pain or acute coronary syndrome with implantation of at least one BVS (Absorb, Abbott Vascular) and followed up by telephone interview and review of medical charts were included in a singlecenter, prospective, all-comers, first in Russia registry. The primary endpoint, target vessel failure, defined as the combination of cardiac death, target vessel myocardial infarction, or clinically driven target vessel revascularization and secondary endpoints, MACCE (composite of cardiovascular death, myocardial infarction, coronary artery bypass surgery, target vessel revascularization, stroke) and stent thrombosis, were assessed during 6-month follow-up.Results. A total of 500 patients with coronary artery disease (CAD) (stable CAD 54.4%, acute coronary syndrome 45.6%) and different amount of affected vessels (1 vessel CAD 40.8%, n = 204; 2-vessel CAD 32.8%, n = 164; 3-vessel CAD 26.4%, n = 132) received 664 scaffolds and 55 stents in 603 stenoses. Procedure success, defined as a residual stenosis less than 30% and TIMI 3 flow in target vessel at the end of procedure, was observed in 98.51% (n = 594). At the moment of 6-month follow-up 4.2% (n = 24) of patients were lost to contact. After 6 months, incidence of target vessel failure and MACCE was 4.2% (n = 21) and 5% (n = 25). The cumulative rate of definite/probable scaffold thrombosis was 1.6% (n = 8).Conclusion. The interim analysis of Gabi-R: Russia registry, the largest trial of BVS Absorb implantation in routine clinical practice, showed high procedural success and low incidence of adverse events during follow-up. However, a tendency to high incidence of scaffold thrombosis compared to drug-eluting stents can be observed. Considering the long-term results of randomized trials retrospective registries, safety in terms of BVS routine use is of big concern. Longterm 24-month data regarding safety endpoints are required to test the afore-mentioned suggestion. Received 5 January 2019. Revised 28 March 2019. Accepted 29 March 2019.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.
The Ultimate Expert: A Patient's Perspective
Authors: Scott Jessa
Published: May 2019

In this issue of Advances in Pulmonary Hypertension, Editor-in-Chief Erika Rosenzweig, MD, asked a former patient: Can you give us your first-hand perspective, the good and the bad, as a young patient dealing with pulmonary hypertension?
Approach to the Child With Pulmonary Hypertension and Bronchopulmonary Dysplasia
Authors: Abman Steven H.
Published: May 2019

Pulmonary vascular disease and pulmonary hypertension contribute to the pathophysiology and outcomes of infants with bronchopulmonary dysplasia. Data are extremely limited regarding many aspects of pulmonary hypertension in bronchopulmonary dysplasia, including the need to learn more about its natural history and prevalence, mechanisms that cause pulmonary hypertension or contribute to progressive disease, and the relative risks and benefits of current therapeutic strategies. Although new therapies are now available for the treatment of pulmonary hypertension, their role in the clinical care of severe bronchopulmonary dysplasia, and improving long-term outcomes requires more thorough investigation.
PAH and Pregnancy: Physiologic Changes, Challenges, and Outcomes
Authors: Zwicke Dianne L.
Published: May 2019

For most expectant mothers, pregnancy is a happy time. It is a time of scheduled obstetrical appointments, prenatal vitamins, prenatal classes, and baby showers, with the greatest concern being shopping for the anticipated family addition. No one “expects” complications or a new diagnosis during their pregnancy. When complications do occur, the majority are related to the development of the fetus, not the health of the mother. Unfortunately, idiopathic pulmonary arterial hypertension (IPAH) is an unforgiving and devastating disease, and as many as 80% of new diagnoses are made during the child-bearing years. Review of the usual cardiopulmonary and hemodynamic changes of a normal pregnancy, along with those that occur in the maladaptive state of pregnancy concurrently with pulmonary arterial hypertension (PAH), are therefore necessary to appreciate the treatment and management.
The Pediatric Sildenafil Trial
Authors: Ivy Dunbar
Published: May 2019

While we have long understood pulmonary arterial hypertension (PAH) to be a chronic disorder of the pulmonary vasculature that can lead to right heart failure and death if untreated, there are currently no therapies approved for children. Recommendations for treatment for children have been derived from evidence-based adult guidelines. However, limited data suggest benefits for children utilizing drugs approved for adults. This landmark study is the first randomized, double-blind, placebo-controlled trial of a PAH therapy in children.