bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparisons and Associations between Hip-Joint Position Sense and Glycosylated Hemoglobin in Elderly Subjects with Type 2 Diabetes Mellitus—A Cross-Sectional Study
Authors: Asiri Faisal , Reddy Ravi Shankar , Narapureddy Bayapa Reddy , Raizah Abdullah
Published: November 2022

Hip-joint position sense (JPS) accuracy may be impaired in individuals with type 2 diabetes mellitus (T2DM). An impaired hip JPS can alter postural control and bodily balance. The objectives of this study are to (1) compare the hip JPS between T2DM and asymptomatic and (2) assess the relationship between hip JPS and glycosylated hemoglobin (HbAlc). This comparative cross-sectional study included 117 elderly individuals with T2DM (mean age: 59.82 ± 6.80 y) and 142 who were asymptomatic (mean age: 57.52 ± 6.90 y). The hip JPS was measured using a digital inclinometer. The individuals were repositioned to a target position with their eyes closed, and the magnitudes of matching errors were estimated as reposition errors. The hip JPS was evaluated in the flexion and abduction directions. The magnitude of reposition errors was significantly larger in the T2DM group in the right flexion (p < 0.001), the right abduction (p < 0.001), the left flexion (p < 0.001), and the left abduction (p < 0.001) directions compared to the asymptomatic group. HbA1c values showed a significant positive correlation with JPS in the right-hip flexion (r = 0.43, p < 0.001), the right-hip abduction (r = 0.36, p < 0.001), the left-hip flexion (r = 0.44, p < 0.001), and the left-hip abduction (r = 0.49, p < 0.001) directions. Hip JPS testing may be considered when assessing and formulating treatment strategies for individuals with type 2 diabetes. Future research should focus on how hip JPS can impact balance and falls in individuals with T2DM.
Towards a Healthcare Innovation Scaling Framework—The Voice of the Innovator
Authors: Ngongoni Chipo Nancy , Wasswa William , Makubalo Lindiwe , Moeti Matshidiso , Chibi Moredreck
Published: November 2022

This paper investigates the systemic challenges that African healthcare innovators experience in the quest to scale their innovations. The aim is to aggregate insights and to conceptualize a foundation towards building a framework that can be used as a guide by intermediary organizations and global partners to support collaborative innovation in African countries. These insights were gained from analyzing a dataset of survey responses obtained from a follow-up on 230 innovators who took part in the inaugural WHO Africa Innovation Challenge that was held in 2018. The insights led to the identification of 10 key foundational blocks that assist in ecosystem management in a bid to strengthen national health innovation ecosystems and to improve the sustainability and integration of innovations in the health system.
Association between the Health Belief Model, Exercise, and Nutrition Behaviors during the COVID-19 Pandemic
Authors: Kiely Keagan , Mase William A. , Hansen Andrew R. , Schwind Jessica
Published: November 2022

Introduction: The COVID-19 pandemic has affected our nation’s health further than the infection it causes. Physical activity levels and dietary intake have suffered while individuals grapple with the changes in behavior to reduce viral transmission. With unique nuances regarding the access to physical activity and nutrition during the pandemic, the constructs of Health Belief Model (HBM) may present themselves differently in nutrition and exercise behaviors compared to precautions implemented to reduce viral transmission studied in previous research. The purpose of this study was to investigate the extent of exercise and nutritional behavior change during the COVID-19 pandemic and explain the reason for and extent of this change using HBM constructs (perceived susceptibility, severity, benefit of action, and barriers to action). Methods: This study used a cross-sectional design to collect 206 surveys. This survey collected information on self-reported exercise and nutrition changes during the pandemic and self-reported levels of the HBM constructs. Results: Findings showed individuals with medium or high exercise behavior change had greater odds of increased HBM score than individuals with little to no exercise behavior change (OR = 1.117, 95% CI: 1.020–1.223, SE: 0.0464, p = 0.0175). There was no association between nutritional behavior change and HBM score (OR = 1.011, 95% CI: 0.895–1.142, p = 08646). Conclusion: Individuals who reported a more drastic change in either exercise had greater odds of increased feelings of perceived susceptibility and severity related to COVID-19 and decreased perceived benefits and increased barriers to exercise. This relationship was not found regarding nutrition behavior change. These results encourage public health practitioners to understand how an individual’s perceived feelings about a threat may affect exercise and nutritional behaviors.
The Impact of the COVID-19 Pandemic and Associated Societal Restrictions on People Experiencing Homelessness (PEH): A Qualitative Interview Study with PEH and Service Providers in the UK
Authors: Dawes Jo , May Tom , Fancourt Daisy , Burton Alexandra
Published: November 2022

People experiencing homelessness (PEH) faced unique challenges during the COVID-19 pandemic, including changes to accommodation availability, societal restrictions impacting access to essentials like food, and services moving to online and remote access. This in-depth qualitative research aims to add to the existing, but limited research exploring how the pandemic affected PEH. 33 semi-structured qualitative interviews (22 with PEH during the pandemic and 11 with homelessness sector service providers) were undertaken in the United Kingdom between April 2021 and January 2022. Interviews were audio-recorded, transcribed and analysed using reflexive thematic analysis. To ensure consistency of coding, 10% of interviews were coded by two researchers. The PEH sample was 50% female, aged 24–59 years, 59% white British, and included people who had lived in hostels/hotels, with friends/family, and on the streets during the COVID-19 pandemic. Providers came from varied services, including support charities, housing, and addiction services. Five key themes were identified: (i) the understanding of and adherence to public health guidance and restrictions; (ii) the experience of people accommodated by the ‘Everyone In’ initiative; (iii) the impact of social distancing guidelines on PEH experiences in public spaces; (iv) the importance of social support and connections to others; and (v) how homelessness services adapted their provision. Policy makers and public health communicators must learn from PEH to maximize the effectiveness of future public health strategies. Housing providers and support services should recognize the implications of imposing a lack of choice on people who need accommodation during a public health emergency. The loss of usual support for PEH triggered a loss of ability to rely on usual ‘survival strategies’, which negatively influenced their health. This research highlights successes and difficulties in supporting PEH during the COVID-19 pandemic and informs planning for similar public health events.
Validation of a Nursing Workload Measurement Scale, Based on the Classification of Nursing Interventions, for Adult Hospitalization Units
Authors: Hellín Gil María Fuensanta , Roldán Valcárcel María Dolores , Seva Llor Ana Myriam , Ibáñez-López Francisco Javier , Mikla Marzena , López Montesinos María José
Published: November 2022

We conducted validation of a scale to measure nursing workloads, previously designed using NIC interventions within the four nursing functions (patient care, teaching, management, and research). Methods: This is an analytical, descriptive, prospective, and observational study using qualitative methodology (focus groups and in-depth interviews) with a quantitative and qualitative section (committee of experts and real application of the scale through a validation pilot and with multicentric application, including hospitalization units of internal medicine and surgery of four hospitals). Qualitative analysis was performed with Atlas.ti8 and quantitative analysis with R. Results: Qualitatively, all the participants agreed on the need to measure workloads in all nursing functions with standardized terminology. The expert committee found greater relevance (91.67%) in “prevention” and “health education” as well as consistency with the construct and adequate wording in 99% of the selected items. In the pilot test and multicenter application, the nurses spent more time on the caring dimension, in the morning shift, and on the items “self-care”, “medication”, “health education”, “care of invasive procedures”, “wounds care”, “comfort”, and “fluid therapy”. Cronbach’s alpha 0.727, composite reliability 0.685, AVE 0.099, and omega coefficient 0.704 were all acceptable. Construct validity: KMO 0.5 and Bartlett’s test were significant. Conclusions: The scale can be considered valid to measure nursing workloads, both qualitatively in obtaining the consensus of experts and health personnel and quantitatively, with acceptable reliability and validity superior to other similar scales.
Does Adult Children’s Education Increase Parents’ Longevity in China?
Authors: Ma Yanna , Ma Zhanli , Yang Moqin
Published: November 2022

The populations of some developing countries are aging rapidly, while the average years of schooling for residents are also constantly increasing. However, the question of whether adult children’s education affects the longevity of their older parents remains understudied. This study used China Health and Retirement Longitudinal Survey data to estimate the causal impact of adult children’s education on their parents’ longevity using a truncated regression model. We found that, for every one-unit increase in adult children’s education, fathers’ and mothers’ longevity increases by 0.89 and 0.75 years, respectively. The mechanism analysis shows that adult children’s education significantly increases their provision of emotional and financial support to their parents, as well as their parents’ self-reported health. Further evidence shows that for every one-unit increase in adult children’s education, the longevity of their fathers-in-law and mothers-in-law also increases by 0.40 and 0.46 years, respectively. Improving the level of adult children’s education can thus increase parents’ and parents-in-law’s longevity via three channels: providing emotional and financial support and improving health. A culture in which parents value their children’s education should thus be promoted.
Model-Based Biomechanical Exoskeleton Concept Optimization for a Representative Lifting Task in Logistics
Authors: Schiebl Jonas , Tröster Mark , Idoudi Wiem , Gneiting Elena , Spies Leon , Maufroy Christophe , Schneider Urs , Bauernhansl Thomas
Published: November 2022

Occupational exoskeletons are a promising solution to prevent work-related musculoskeletal disorders (WMSDs). However, there are no established systems that support heavy lifting to shoulder height. Thus, this work presents a model-based analysis of heavy lifting activities and subsequent exoskeleton concept optimization. Six motion sequences were captured in the laboratory for three subjects and analyzed in multibody simulations with respect to muscle activities (MAs) and joint forces (JFs). The most strenuous sequence was selected and utilized in further simulations of a human model connected to 32 exoskeleton concept variants. Six simulated concepts were compared concerning occurring JFs and MAs as well as interaction loads in the exoskeleton arm interfaces. Symmetric uplifting of a 21 kg box from hip to shoulder height was identified as the most strenuous motion sequence with highly loaded arms, shoulders, and back. Six concept variants reduced mean JFs (spine: >70%, glenohumeral joint: >69%) and MAs (back: >63%, shoulder: >59% in five concepts). Parasitic loads in the arm bracing varied strongly among variants. An exoskeleton design was identified that effectively supports heavy lifting, combining high musculoskeletal relief and low parasitic loads. The applied workflow can help developers in the optimization of exoskeletons.
Intelligent Manufacturing and Carbon Emissions Reduction: Evidence from the Use of Industrial Robots in China
Authors: Lv Hao , Shi Beibei , Li Nan , Kang Rong
Published: November 2022

Driven by the information technology revolution, using artificial intelligence to promote intelligent manufacturing while achieving carbon emissions reduction is increasingly the focus of international attention. Given this, based on the fact that China’s industrial manufacturing is more intelligent, this paper uses industrial sector data and robot data from 2000 to 2017 to examine the impact of intelligent manufacturing on industrial carbon dioxide emissions and to discuss its internal mechanism. The research found that intelligent manufacturing significantly inhibits carbon dioxide emissions in the industrial sectors. The emission reduction effect is more obvious in industries with higher carbon emissions and intelligence. The mechanism test shows that intelligent manufacturing mainly achieves industrial emission reduction by reducing fossil energy consumption in the production process and improving energy use efficiency. The research findings of this paper provide favorable evidence for using new technologies, such as artificial intelligence, to achieve carbon emissions reduction, and validate the importance of intelligent manufacturing in tackling climate change in the future. It provides an essential reference for developing countries to use artificial intelligence for their carbon emissions reduction goals.
Evolution of Low Carbon Supply Chain Research: A Systematic Bibliometric Analysis
Authors: Du Qiang , Zhou Jiajie
Published: November 2022

With the increasingly serious global carbon emission problem, how to reduce carbon emissions has attracted a great deal of attention from academics and practitioners. Carbon emissions can be decreased more efficiently by coordinating the management of firms upstream and downstream in the supply chain, which has an increasingly important role in the low carbon process. Research on the low carbon supply chain (LCSC) has gradually evolved into important branches of global sustainable development. This paper aims to conduct a complete thematic analysis of 754 articles published between 2012 and 2021, identify the structural dimensions of evolution, and classify them according to systematic methodology. It provides a stage-by-stage summary of relevant research results from the past decade. At present, research in the LCSC field has resulted in a complete theoretical framework and research system and has formed the evolutionary path of method-policy-practice research. This study will help to promote further in-depth study of the LCSC and the fabrication and improvement of its theoretical system. It provides a valuable reference for researchers interested in LCSC, and points out the focus and direction of future research.
Effects of Household Processing on Residues of the Chiral Fungicide Mandipropamid in Four Common Vegetables
Authors: Mu Shiyin , Dou Li , Ye Yu , Chi Du , Zhang Kankan
Published: November 2022

The study aimed to detect the content of mandipropamid enantiomers in unprocessed and processed tomato, cucumber, Chinese cabbage, and cowpea samples and assess the health risks to Chinese consumers. Data showed that washing and soaking with an acidic solution reduced the mandipropamid residue from vegetable samples by 54.1–82.2%. The pickling process resulted in a 6.2–65.2% loss of mandipropamid from cucumber, Chinese cabbage, and cowpea samples. Peeling and juicing were the best removing techniques for mandipropamid residues in tomato and cucumber (removal rate (RR) value > 91%), and cooking for 5 min could effectively reduce the levels of mandipropamid in Chinese cabbage and cowpea (RR values of 81.4–99.7%). The values of processing factor for the processed vegetable samples are all less than one. No significant enantioselectivity of mandipropamid was found in the vegetables during processing. Health risk data showed that samples of four types of mandipropamid-contaminated vegetables were safe for consumption after processing.
Association between Internet Usage and Quality of Life of Elderly People in England: Evidence from the English Longitudinal Study of Ageing (ELSA)
Authors: Vidiasratri Agatha Ravi , Bath Peter A.
Published: November 2022

The WHO has stated that the number of senior citizens above age 65 across the world will double by the year 2050: in the UK, the whole population is projected to grow by about 2.5% over a decade, from mid-2018. Although people are living longer, they are not healthier in old age, and there is an increasing number of illnesses and disabilities in the ageing population, which have an impact on their overall well-being and quality of life (QoL). Alongside these trends, Internet technologies have improved and provide a wide range of information, including on medical and health issues. This study aimed to examine the association between the utilisation of the internet among older people in England and their QoL. This study utilised the English Longitudinal Study of Aging (ELSA), a longitudinal study of a representative sample of people aged 50 and over in England. The data from Wave 9 were analysed using bivariate analysis and logistic regression. The results show a strong association between QoL and utilisation of the Internet in older people, even when adjusting for demographic variables and health. Higher use of the internet was associated with older people being less likely to have higher QoL. The excessive use of the internet for communication and gathering information also contributed to lower QoL. From the findings, poorer QoL was also found in people in older age groups, in those who are married, and those who never suffer from chronic diseases. Our findings suggest that the quality of life in older people might not only be associated with the frequency of usage but also the purpose for which the internet is used; however, this relationship is complex and further research should explore this in greater depth. Further research should also investigate how older people’s use of the Internet changed during the COVID-19 pandemic and the effects of this on the QoL in older age.
Sexual Dysfunction among Gynaecological Cancer Survivors: A Descriptive Cross-Sectional Study in Malaysia
Authors: Mohamad Muhit Akmal Muzamir , Sy-Cherng Woon Luke , Nik Mhd Nor Nik Sumayyah , Sidi Hatta , Mohd Kalok Aida Hani , Kampan Nirmala @ Chandralega , Shafiee Mohamad Nasir
Published: November 2022

Background: Sexual dysfunction is a major issue among gynaecological cancer survivors. This study aimed to evaluate the prevalence of sexual dysfunction among survivors of gynaecological cancer in Malaysia and to determine its risk factors. Methods: A cross-sectional study was conducted of 116 married women with gynaecological cancer who attended the gynaeoncology and oncology clinics at Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Sociodemographic and clinical data were collected. Sexual dysfunction was measured using the Malay Version Female Sexual Function Index (MVFSFI). Univariate and multivariate logistic regression analyses were used to determine the risk factors of female sexual dysfunction. Results: The prevalence of sexual dysfunction among gynaecological cancer survivors was 60% (70 out of 116). Sexual dissatisfaction was the most prevalent domain of sexual dysfunction at 68.1%. Sexual dysfunction was significantly associated with low education levels (Primary level, AOR = 4.92, 95% CI: 1.12–21.63; secondary level, AOR = 4.06, 95% CI: 1.14–14.44). Non-Malays were significantly more likely to have sexual dysfunction compared with Malays (AOR = 3.57, 95% CI: 1.16–11.06). In terms of treatment, combinations of surgery and radiotherapy (AOR = 4.66, 95% CI: 1.01–21.47) as well as surgery and chemoradiation (AOR = 5.77, 95% CI: 1.20–27.85) were considered. Conclusions: Gynaecological cancer survivors with lower education levels, non-Malay ethnicity, and receiving treatment combinations of surgery and radiotherapy or surgery and chemoradiation have a higher risk of sexual dysfunction. A holistic approach in managing the various sociocultural and clinical issues is required to prevent sexual dysfunction among these patients.
Environmental and Moral Education for Effective Environmentalism: An Ideological and Philosophical Approach
Authors: Begum Abida , Liu Jingwei , Qayum Hina , Mamdouh Amr
Published: November 2022

This article offers a critical review of the research on moral and environmental education as a basis for building environmentalism. The review’s objective is to present an ideological and philosophical theory and research on environmentalism through moral education. The bulk of this research involves empirical research that examines the correlation between moral education and environmentalism, ideologies produced by moral education, and philosophical arguments inherent in environmental education. A deductive argument is made following the review of the existing research on moral education to highlight the educational approaches that have been hailed as effective. Some of the environmental educational approaches identified as being effective include proactive environmental education, creating an environmentally conscious environment, and real-life environmental education simulations. The research also identifies moral education whose focus is the creation of a moral consciousness among learners as being critical for the development of environmental consciousness. Inculcation of religious education, creating a moral educational atmosphere, moral leadership, moral life simulations, and use of Ubuntu and Ukamu theoretical frameworks will bolster building a moral consciousness among learners. The argument presented in this article is that despite the existence of some contrary research, moral education can act as a bolster to positive attitudes, actions, and behaviors towards the environment.
Synthesis and Characterization of g-C3N4/Ag3PO4/TiO2/PVDF Membrane with Remarkable Self-Cleaning Properties for Rhodamine B Removal
Authors: Liu Renguo , Li Xue , Huang Jinhui , Pang Haoliang , Wan Qiongfang , Luo Kun , Pang Ya , Wang Lingyu
Published: November 2022

g-C3N4/Ag3PO4/TiO2 nanocomposite materials were loaded onto a polyvinylidene fluoride (PVDF) membrane using a phase inversion method to obtain a photocatalytic flat membrane for dye removal. The morphology, structure, and photocatalytic activity of the g-C3N4/Ag3PO4/TiO2 nanoparticles and composite membrane were evaluated. The g-C3N4/Ag3PO4/TiO2/PVDF membrane exhibited superior morphology, hydrophilic properties, and antifouling performance compared with the raw PVDF membrane. Four-stage filtration was performed to evaluate the self-cleaning and antifouling capacity of the g-C3N4/Ag3PO4/TiO2/PVDF membrane. Upon irradiating the composite membrane with visible light for 30 min, its irreversible fouling resistance (Rir) was low (9%), and its flux recovery rate (FRR) was high (71.0%) after five filtration cycles. The removal rate of rhodamine B (RhB) from the composite membrane under visible light irradiation reached 98.1% owing to the high photocatalytic activity of the membrane, which was superior to that of raw PVDF membrane (42.5%). A mechanism of photocatalytic composite membranes for RhB degradation was proposed. Therefore, this study is expected to broaden prospects in the field of membrane filtration technology.
Comparative Mask Protection against Inhaling Wildfire Smoke, Allergenic Bioaerosols, and Infectious Particles
Authors: Wagner Jeff , Macher Janet M. , Chen Wenhao , Kumagai Kazukiyo
Published: November 2022

This work compares relative mask inhalation protection against a range of airborne particle sizes that the general public may encounter, including infectious particles, wildfire smoke and ash, and allergenic fungal and plant particles. Several mask types available to the public were modeled with respirable fraction deposition. Best-case collection efficiencies for cloth, surgical, and respirator masks were predicted to be lowest (0.3, 0.6, and 0.8, respectively) for particle types with dominant sub-micrometer modes (wildfire smoke and human-emitted bronchial particles). Conversely, all mask types were predicted to achieve good collection efficiency (up to ~1.0) for the largest-sized particle types, including pollen grains, some fungal spores, and wildfire ash. Polydisperse infectious particles were predicted to be captured by masks with efficiencies of 0.3–1.0 depending on the pathogen size distribution and the type of mask used. Viruses aerosolized orally are predicted to be captured efficiently by all mask types, while those aerosolized from bronchiolar or laryngeal-tracheal sites are captured with much lower efficiency by surgical and cloth masks. The predicted efficiencies changed very little when extrathoracic deposition was included (inhalable rather than respirable fraction) or when very large (100 µm) particles were neglected. Actual mask fit and usage will determine protection levels in practice, but the relative comparisons in this work can inform mask guidance for different inhalation hazards, including particles generated by yard work, wildfires, and infections.
Disparity and Spatial Heterogeneity of the Correlation between Street Centrality and Land Use Intensity in Jinan, China
Authors: Yin Guanwen , Liu Tianzi , Chen Yanbin , Hou Yiming
Published: November 2022

In the existing literature on the correlation between street centrality and land use intensity (LUI), only a few studies have explored the disparity of this correlation for different types of LUI and the differences across various locations. In response to the above shortcomings, in this study, the main urban area of Jinan, China, was taken as an example, and the disparity and spatial heterogeneity of the correlation between street centrality and LUI were explored for different categories of land use. The multiple centrality assessment (MCA) model was used to calculate the closeness centrality, betweenness centrality, and straightness centrality of the traffic network. Based on the floor area ratio (FAR) of each parcel, the utilization intensities of the residential, industrial, commercial, and public service land uses were measured. Employing the kernel density estimation (KDE) method, the street centrality of the traffic network vis-à-vis the urban LUI was rasterized into the same spatial analysis framework. The Pearson correlation coefficient and geographically weighted regression (GWR) were used to measure the correlation between the two variables and the spatial heterogeneity of the correlation, respectively. The results showed that traffic network street centrality strongly correlated with the LUI of the residential, commercial, and public service land use types, but it had a very weak association with the LUI of industrial land use. The GWR results also confirmed the spatial heterogeneity of the correlation. The results of this research highlighted the important role of traffic network street centrality in understanding the urban spatial structure. The study also helped to explain the dynamic mechanism of the road network form and the topological structure of urban spatial evolution.
Test of the Rehabilitation Goal Screening (ReGoS) Tool to Support Decision Making and Goal Setting in Physical and Rehabilitation Medicine Practice
Authors: Gutenbrunner Christoph , Korallus Christoph , Egen Christoph , Schiller Joerg , Sturm Christian , Teixido Lidia , Eckhardt Isabelle , Boekel Andrea
Published: November 2022

Background: It has already been shown that it is feasible to use International Classification of Functioning, Disability and Health (ICF) Sets as self-assessment instruments. We used this idea to design an ICF-based screening tool to assess patients of a broadly based rehabilitation department. It was developed for the purpose of having a screening tool before taking the anamnesis, as well as for rehabilitation planning and follow-up. Methods and Materials: The Rehabilitation Goal Screening (ReGoS) instrument is a self-report questionnaire which was developed based on the most relevant domains from the ICF Core Sets for chronic pain and rehabilitation. The ICF categories were translated into plain language and 0–10 Likert scales were used. A retrospective analysis of routine clinical data using the ReGoS tool, Work Ability Index (WAI) and Hospital Anxiety and Depression Scale (HADS) in paper- or tablet-based form was performed. Results: The average age of the N = 1.008 respondents was 53.9 years (SD = 16.2). Of the respondents, 66% (n = 665) were female. At the time of the survey, 48.3% (n = 487) of the patients were employed. ReGoS results demonstrated that the highest restrictions on a scale from 0 to 10 were found in the areas of energy and drive (M = 5.79, SD = 2.575) and activities of daily living (M = 5.54, SD = 2.778). More than a third of the respondents rated their work ability as critical. Conclusion: The use of the ReGoS instrument as an ICF-based screening tool based on a self-report questionnaire provides relevant information for clinical diagnosis, participative goal setting and a detailed functional capacity profile.
Clinical and Pathological Manifestation of the Oral Mucosa in Institutionalized Children from Romania
Authors: Stoica Alexandra Mihaela , Kovacs-Ivacson Csinszka Andrea , Stoica Oana Elena , Beresescu Liana , Monea Monica
Published: November 2022

Institutionalized children, regardless of their age, are prone to psychiatric disorders, compared to those who live in two-parent families, due to the unfavorable physical and psychological conditions in which they develop. Unpropitious psychological conditions affect the child’s general health and induce local manifestations that can be found in the oral cavity, affecting both soft tissues and teeth. Therefore, the purpose of our study was to assess and diagnose a series of pathological manifestations of the oral mucosa associated with poor living conditions or closely related to psychological stress. The clinical examination was performed by 4 specialist dentists, who consulted 150 children representing the study group and 52 children representing the control group, all having ages between 14 and 18 years old and meeting the same inclusion criteria. From the control group, 62.5% presented plaque-induced gingivitis (26.6% girls, 35.8% boys), 26.6% presented mucosal lesions produced by lip and cheek biting (23.3% girls, 35.8% boys), and 11.7% presented geographic tongue (6.6% girls, 5% boys), herpes simplex eruptions (3.3% girls, 4.2% boys) and oral ulcerations (12.5% girls, 10.8% boys). Morsicatio buccarul is a chronic, self-mutilating habit, currently becoming one of the most common tics encountered among institutionalized children. Furthermore, these children do not benefit from constant support and guidance to perform their dental hygiene, so the incidence of gingivitis induced by bacterial plaque and calculus is very high.
Impact of the COVID-19 Pandemic on the Female Sexual Function Index and Female Behavioral Changes: A Cross-Sectional Survey Study in Thailand
Authors: Narkkul Udomsak , Jiet Ng Jun , Saraluck Apisith
Published: November 2022

Sexual health alterations are associated with disasters. Consequently, the COVID-19 pandemic may affect female sexual function. This study aimed to determine the COVID-19 pandemic effect on female sexual function and to know the risk of female sexual dysfunction. This online, cross-sectional, observational research was conducted during the pandemic period. A logistic regression model was used to investigate the associations between outcomes and potential risk factors. In total, 432 sexually active women participating in the region affected by the COVID-19 pandemic were analyzed. The overall findings of our study are that 60 percent of females were at risk for female sexual dysfunction. The average FSFI score was 21.27 ± 7.17. Comparing female sexual behavior before and during the COVID-19 pandemic reveals a significant decrease in the frequency of having sex per week, foreplay duration, and coital duration. In the multivariate analysis, the factors associated with the development of RFSD are age greater than 45 years (adjusted odds ratios (AOR) 15.09, 95% confidence interval (CI) 3.67–62.07), body mass index (BMI) greater than 25 (AOR 3.26, 95%CI 1.23–8.67), jobs as a healthcare provider (AOR 8.45, 95%CI 3.66–19.53), previous COVID-19 infection within the previous three months (AOR 36.81, 95%CI 10.93–123.98), and screened-positive anxiety (AOR 13.07, 95%CI 4.75–35.94). COVID-19 influences female sexual behavior and may increase the risk of sexual dysfunction in women. Concern for the effects of female sexual quality of life in high-risk individuals is essential.
Meanings Attributed to Physical Activity and Changes in Self-Reported and Accelerometer-Measured Physical Activity among Recent Retirees
Authors: Tuominen Miika , Stenholm Sari , Koski Pasi , Leskinen Tuija
Published: November 2022

Retirement poses opportunities and challenges for maintaining and adopting physically active habits, which may have major implications for health and functional ability in later life. Qualitative studies suggest that a broad range of meanings of physical activity should be considered when promoting physical activity among retirees. The current study utilized the Physical Activity Relationship (PAR) approach to examine the importance of meanings attributed to physical activity and their associations with physical activity over time. A total of 230 recently retired participants (65.2 years old, 83% women) responded to a 54-item inventory assessing the importance of meanings attributed to physical activity at baseline. Eight meaning dimensions were identified through exploratory factor analysis. Differences in their importance across gender and occupational background were examined using t-tests and ANOVA. Associations between meaning dimensions and self-reported and accelerometer-measured physical activity over 12 months were examined with general linear models. Dimensions defined as Physical Fitness, Positive Mood, and Belonging were positively associated with changes in self-reported and accelerometer-measured physical activity. Additionally, the importance of several meaning dimensions varied across occupational background. In conclusion, physical activity promotion among retirees should focus on physical fitness, positive mood, and social belonging. Furthermore, meanings attributed to physical activity may vary across occupational backgrounds.
Nurses’ Work-Related Mental Health in 2017 and 2020—A Comparative Follow-Up Study before and during the COVID-19 Pandemic
Authors: Nagel Cicilia , Nilsson Kerstin
Published: November 2022

The COVID-19 pandemic put a lot of strain on healthcare organizations. Nurses account for over 50% of healthcare staff, and how nurses perform in their work is influenced by a number of human and work environmental factors. However, to our knowledge, there has not been a previous study with the intention to look at all areas that affect a sustainable working life and how these impact nurses’ mental well-being. The aim of this study is to investigate the association between, and the effect of, different factors in nurses’ work situations associated with nurses’ work-related mental-health diagnoses, before and during the COVID-19 pandemic. A questionnaire was sent out to all 9219 nurses in the Swedish county of Skane in the spring of 2017 and during wave two of the COVID-19 pandemic in the fall of 2020. The data were analyzed through logistic regression analysis. The results showed that lack of joy in the daily work, an increased workload and lack of support from co-workers had an increased association with work-related mental-health diagnoses. Future research regarding the long-term impact of COVID-19 on all areas of nurses’ professional and personal lives is needed.
Role of Biomarkers in the Management of Acute Myeloid Leukemia
Authors: Small Sara , Oh Timothy S. , Platanias Leonidas C.
Published: November 2022

Despite many recent advances in treatment options, acute myeloid leukemia (AML) still has a high mortality rate. One important issue in optimizing outcomes for AML patients lies in the limited ability to predict response to specific therapies, duration of response, and likelihood of relapse. With evolving genetic characterization and improving molecular definitions, the ability to predict outcomes and long-term prognosis is slowly improving. The majority of the currently used prognostic assessments relate to molecular and chromosomal abnormalities, as well as response to initial therapy. These risk categories, however, do not account for a large amount of the variability in AML. Laboratory techniques now utilized in the clinic extend beyond bone marrow morphology and single gene sequencing, to next-generation sequencing of large gene panels and multiparameter flow cytometry, among others. Other technologic advances, such as gene expression analysis, have yet to demonstrate enough predictive and prognostic power to be employed in clinical medicine outside of clinical trials, but may be incorporated into the clinic in the future. In this review, we discuss the utility of current biomarkers, and present novel biomarker techniques and strategies that are in development for AML patients. Measurable residual disease (MRD) is a powerful prognostic tool that is increasingly being incorporated into clinical practice, and there are some exciting emerging biomarker technologies that have the potential to improve prognostic power in AML. As AML continues to be a difficult-to-treat disease with poor outcomes in many subtypes, advances in biomarkers that lead to better treatment decisions are greatly needed.
Mechanisms of Susceptibility and Resilience to PTSD: Role of Dopamine Metabolism and BDNF Expression in the Hippocampus
Authors: Tseilikman Vadim E. , Tseilikman Olga B. , Pashkov Anton A. , Ivleva Irina S. , Karpenko Marina N. , Shatilov Vladislav A. , Zhukov Maxim S. , Fedotova Julia O. , Kondashevskaya Marina V. , Downey H. Fred , Manukhina Eugenia B.
Published: November 2022

Susceptibility and resilience to post-traumatic stress disorder (PTSD) are recognized, but their mechanisms are not understood. Here, the hexobarbital sleep test (HST) was used to elucidate mechanisms of PTSD resilience or susceptibility. A HST was performed in rats 30 days prior to further experimentation. Based on the HST, the rats were divided into groups: (1) fast metabolizers (FM; sleep duration < 15 min); (2) slow metabolizers (SM; sleep duration ≥ 15 min). Then the SM and FM groups were subdivided into stressed (10 days predator scent, 15 days rest) and unstressed subgroups. Among stressed animals, only SMs developed experimental PTSD, and had higher plasma corticosterone (CORT) than stressed FMs. Thus, resilience or susceptibility to PTSD was consistent with changes in glucocorticoid metabolism. Stressed SMs had a pronounced decrease in hippocampal dopamine associated with increased expressions of catecholamine-O-methyl-transferase and DA transporter. In stressed SMs, a decrease in monoaminoxidase (MAO) A was associated with increased expressions of hippocampal MAO-A and MAO-B. BDNF gene expression was increased in stressed FMs and decreased in stressed SMs. These results demonstrate relationships between the microsomal oxidation phenotype, CORT concentration, and anxiety, and they help further the understanding of the role of the liver–brain axis during PTSD.
Vascularization Strategies in 3D Cell Culture Models: From Scaffold-Free Models to 3D Bioprinting
Authors: Anthon Shamapto Guha , Valente Karolina Papera
Published: November 2022

The discrepancies between the findings in preclinical studies, and in vivo testing and clinical trials have resulted in the gradual decline in drug approval rates over the past decades. Conventional in vitro drug screening platforms employ two-dimensional (2D) cell culture models, which demonstrate inaccurate drug responses by failing to capture the three-dimensional (3D) tissue microenvironment in vivo. Recent advancements in the field of tissue engineering have made possible the creation of 3D cell culture systems that can accurately recapitulate the cell–cell and cell–extracellular matrix interactions, as well as replicate the intricate microarchitectures observed in native tissues. However, the lack of a perfusion system in 3D cell cultures hinders the establishment of the models as potential drug screening platforms. Over the years, multiple techniques have successfully demonstrated vascularization in 3D cell cultures, simulating in vivo-like drug interactions, proposing the use of 3D systems as drug screening platforms to eliminate the deviations between preclinical and in vivo testing. In this review, the basic principles of 3D cell culture systems are briefly introduced, and current research demonstrating the development of vascularization in 3D cell cultures is discussed, with a particular focus on the potential of these models as the future of drug screening platforms.
19S Proteasome Subunits as Oncogenes and Prognostic Biomarkers in FLT3-Mutated Acute Myeloid Leukemia (AML)
Authors: Lara Joshua J. , Bencomo-Alvarez Alfonso E. , Gonzalez Mayra A. , Olivas Idaly M. , Young James E. , Lopez Jose L. , Velazquez Vanessa V. , Glovier Steven , Keivan Mehrshad , Rubio Andres J. , Dang Sara K. , Solecki Jonathan P. , Allen Jesse C. , Tapia Desiree N. , Tychhon Boranai , Astudillo Gonzalo E. , Jordan Connor , Chandrashekar Darshan S. , Eiring Anna M.
Published: November 2022

26S proteasome non-ATPase subunits 1 (PSMD1) and 3 (PSMD3) were recently identified as prognostic biomarkers and potential therapeutic targets in chronic myeloid leukemia (CML) and multiple solid tumors. In the present study, we analyzed the expression of 19S proteasome subunits in acute myeloid leukemia (AML) patients with mutations in the FMS-like tyrosine kinase 3 (FLT3) gene and assessed their impact on overall survival (OS). High levels of PSMD3 but not PSMD1 expression correlated with a worse OS in FLT3-mutated AML. Consistent with an oncogenic role for PSMD3 in AML, shRNA-mediated PSMD3 knockdown impaired colony formation of FLT3+ AML cell lines, which correlated with increased OS in xenograft models. While PSMD3 regulated nuclear factor-kappa B (NF-κB) transcriptional activity in CML, we did not observe similar effects in FLT3+ AML cells. Rather, proteomics analyses suggested a role for PSMD3 in neutrophil degranulation and energy metabolism. Finally, we identified additional PSMD subunits that are upregulated in AML patients with mutated versus wild-type FLT3, which correlated with worse outcomes. These findings suggest that different components of the 19S regulatory complex of the 26S proteasome can have indications for OS and may serve as prognostic biomarkers in AML and other types of cancers.
Human Orphan Cytochrome P450 2U1 Catalyzes the ω-Hydroxylation of Leukotriene B4
Authors: Nouri Khawla , Pietrancosta Nicolas , Le Corre Laurent , Dansette Patrick M. , Mansuy Daniel , Boucher Jean-Luc
Published: November 2022

Cytochrome P450 2U1 (CYP2U1) identified from the human genome remains poorly known since few data are presently available on its physiological function(s) and substrate(s) specificity. CYP2U1 mutations are associated with complicated forms of hereditary spastic paraplegia, alterations of mitochondrial architecture and bioenergetics. In order to better know the biological roles of CYP2U1, we used a bioinformatics approach. The analysis of the data invited us to focus on leukotriene B4 (LTB4), an important inflammatory mediator. Here, we show that CYP2U1 efficiently catalyzes the hydroxylation of LTB4 predominantly on its ω-position. We also report docking experiments of LTB4 in a 3D model of truncated CYP2U1 that are in agreement with this hydroxylation regioselectivity. The involvement of CYP2U1 in the metabolism of LTB4 could have strong physiological consequences in cerebral pathologies including ischemic stroke because CYP2U1 is predominantly expressed in the brain.
Study of the Repellent Activity of 60 Essential Oils and Their Main Constituents against Aedes albopictus, and Nano-Formulation Development
Authors: Wu Weifeng , Yang Yu , Feng Yingmiao , Ren Xiaofei , Li Yuling , Li Wenjiao , Huang Jietong , Kong Lingjia , Chen Xiaole , Lin Zhongze , Hou Xiaohui , Zhang Longlai , Chen Yajie , Sheng Zhaojun , Hong Weiqian
Published: November 2022

Mosquitoes are one of the most important disease vectors from a medical viewpoint in that they transmit several diseases such as malaria, filariasis, yellow and Dengue fever. Mosquito vector control and personal protection from mosquito bites are currently the most efficient ways to prevent these diseases. Several synthetic repellents such as DEET, ethyl butylacetylaminopropionate (IR3535) and 1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine) (Picaridin), have been widely used to prevent humans from receiving mosquito bites. However, the use of synthetic repellents has raised several environment and health concerns. Therefore, essential oils (EOs) as natural alternatives receive our attention. In order to discover highly effective mosquito repellents from natural sources, the repellent activity of 60 commercial EOs against Ae. albopictus was screened in this study. Eight EOs including cinnamon, marjoram, lemongrass, bay, chamomile, jasmine, peppermint2, and thyme, showed a suitable repellent rate (>40%) at the tested dose of 10 μg/cm2. Then, their main constituents were analyzed by GC-MS, and the active constituents were identified. The most active compounds including cinnamaldehyde, citral and terpinen-4-ol, exhibited an 82%, 65% and 60% repellent rate, respectively. Moreover, the nanoemulsions of the three active compounds were prepared and characterized. In the arm-in-cage assay, the protection times of the nanoemulsions of cinnamaldehyde and citral were significantly extended compared with their normal solutions. This study provides several lead compounds to develop new mosquito repellents, and it suggests that nanoemulsification is an effective method for improving the duration of the activity of natural repellents.
Micromechanical Approach to Predict Mechanical Properties of Particulate-Dispersed Composites with Dissimilar Interfacial Phases
Authors: Fujii Tomoyuki , Tohgo Keiichiro , Omi Takahiro , Shimamura Yoshinobu
Published: November 2022

The mechanical properties of composites are affected by their constituents. For the development of high-performance composites, it is expected that a technique will be developed which can predict the mechanical properties of composites based on the mechanical properties of their constituents. This study developed a technique based on a micromechanical approach to predict the mechanical properties of composites with interfacial phases between reinforcements and matrix. A double-inclusion model (Hori and Nemat-Nasser, 1993) is effective for the solution of such problems, of which the validity remains unclear. Problems with a particle surrounded by an interfacial phase embedded in an infinite body were calculated via the model and finite element analysis to verify the model. It was found that the macroscopic average stress of the double inclusion could be accurately solved by the model, although the microscopic stress of each phase could not be calculated with high accuracy. Therefore, a micromechanical approach based on the model was formulated and applied to particulate-dispersed composites consisting of zirconia and titanium, and fabricated by spark plasma sintering, in which Ti oxides were created along the interface between zirconia and titanium. As a result, the elastic-plastic stress–strain curves of the composites could be predicted. The approach can investigate the mechanical properties of composites with various shapes of reinforcement surrounded by dissimilar materials in a matrix. It can be concluded that the approach is promising for the development of composites with an excellent mechanical performance.