bluuebunny/crossref_metadata_2025 huggingface dataset:
Low-Dose Intravitreal Methotrexate for Proliferative Vitreoretinopathy
Authors: Ullah Asma , Toth Cynthia A. , Burnett Henry W. , Butler John W. , Levy Jay H. , Benner Jeffrey D.
Published: March 2023

Background and Objective:

Proliferative vitreoretinopathy (PVR) has been mitigated by intravitreal methotrexate (MTX) 400 μg/0.1 mL in several studies. Here, we evaluate the results from a lower dose of MTX, 200 μg/0.05 mL.

Materials and Methods:

We identified and reviewed records of patients with grade ≥C1 PVR who were treated with 200 μg/0.05 mL MTX injections: during PVR surgery and every 2 weeks thereafter.

Results:

Twenty-four eyes met inclusion criteria with a mean of 5.6 injections and follow-up ranging 6 to 56 months. The retina was reattached in 19 of 24 eyes (79%) after a single surgery and in 5 of 24 eyes (21%) after one additional PVR surgery. Visual acuity improved from baseline logMAR 1.63 to 0.97 at 12 months (
P
< .001), with 5 of 20 achieving 20/60 or better and 16 of 20 achieving 20/200 or better. One eye developed a transient corneal abrasion that resolved within 1 week.

Conclusion:

Low-dose MTX (200 μg/0.05 mL) during and after PVR surgery resulted in good rates of retinal reattachment and visual acuity recovery.

[
Ophthalmic Surg Lasers Imaging Retina
2023;54(3):139–146.]
An Evaluation of Popular Online Eye Health Products on Amazon Marketplace
Authors: Alsoudi Amer F. , Loya Asad , Abouodah Hythem , Koo Euna , Rahimy Ehsan
Published: March 2023

Background and Objective:

To investigate popular eye health supplements available on Amazon Marketplace to increase awareness about their efficacy, safety, and the validity of their purported benefits.

Materials and Methods:

An observational quantitative and qualitative analysis of the top 100 eye health products was performed in March 2019. To determine the popular online eye health products on Amazon Marketplace, eight keywords were used for the search: “Eye Health,” “Eye Health Supplements,” “Eye Health Vitamins,” “Retina Vitamins,” “Macular Degeneration,” “Macular Degeneration Vitamins,” “Macular Health,” and “Vision Health.” The active ingredients, cost, and customer rating were all recorded.

Results:

No statistically significant association was found between product type and price of the product, number of supplements, average rating, number of customer reviews, or number of verified customer reviews. The average daily cost of the eye health supplements was $0.72 ± $0.55 (range, $0.05 to $2.67).

Conclusion:

This study evaluated popular eye health supplements publicly available on Amazon Marketplace. The findings of this study help both patients and physicians better understand the safety and efficacy of these products so they may make more informed choices when supporting their eye health with commercially available supplements.

[
Ophthalmic Surg Lasers Imaging Retina
2023; 54(3):147–152.]
Checkpoint Inhibitor-Associated Vogt-Koyanagi-Harada Disease Presenting 3 Months Following Discontinuation of Nivolumab
Authors: Tieger Marisa Gobuty , Eliott Dean , Cakir Bertan , Dahrouj Mohammad
Published: March 2023

The use of checkpoint inhibitors has been associated with multiple ocular and orbital complications including Vogt-Koyanagi-Harada disease. In the current case, a 55-year-old man presented with visual changes 3 months following discontinuation of nivolumab for metastatic renal cell carcinoma. This is the second report of delayed presentation following discontinuation of a checkpoint inhibitor and the only case not associated with an alternative targeted therapy at the time of presentation. This article highlights a unique presentation of delayed checkpoint inhibitor-associated Vogt-Koyanagi-Harada and summarizes the reported cases.

[
Ophthalmic Surg Lasers Imaging Retina
2023;54(3):183–187.]
Delayed wave equation with logarithmic variable-exponent nonlinearity
Authors: Kafini Mohammad , Noor Maher
Published: March 2023

A delayed nonlinear wave equation with variable exponents of logarithmic type is discussed in this paper. In the presence of the logarithmic nonlinear source, we established a global existence result under sufficient conditions on the initial data only without imposing the Sobolev Logarithmic Inequality. After that, we established global results of exponential and polynomial types according to the range values of the exponents. At the end, we give a numerical study that supports our theoretical results.
Adopting improved Adam optimizer to train dendritic neuron model for water quality prediction
Authors: Cao Jing , Zhao Dong , Tian Chenlei , Jin Ting , Song Fei
Published: March 2023

As one of continuous concern all over the world, the problem of water quality may cause diseases and poisoning and even endanger people's lives. Therefore, the prediction of water quality is of great significance to the efficient management of water resources. However, existing prediction algorithms not only require more operation time but also have low accuracy. In recent years, neural networks are widely used to predict water quality, and the computational power of individual neurons has attracted more and more attention. The main content of this research is to use a novel dendritic neuron model (DNM) to predict water quality. In DNM, dendrites combine synapses of different states instead of simple linear weighting, which has a better fitting ability compared with traditional neural networks. In addition, a recent optimization algorithm called AMSGrad (Adaptive Gradient Method) has been introduced to improve the performance of the Adam dendritic neuron model (ADNM). The performance of ADNM is compared with that of traditional neural networks, and the simulation results show that ADNM is better than traditional neural networks in mean square error, root mean square error and other indicators. Furthermore, the stability and accuracy of ADNM are better than those of other conventional models. Based on trained neural networks, policymakers and managers can use the model to predict the water quality. Real-time water quality level at the monitoring site can be presented so that measures can be taken to avoid diseases caused by water quality problems.
The function of guanylate binding protein 3 (GBP3) in human cancers by pan-cancer bioinformatics
Authors: Jiang Tongmeng , Jin Pan , Huang Guoxiu , Li Shi-Cheng
Published: March 2023

As a guanylate binding protein (GBPs) member, GBP3 is immune-associated and may participate in oncogenesis and cancer therapy. Since little has been reported on GBP3 in this field, we provide pan-cancer bioinformatics to investigate the role of GBP3 in human cancers. The GBP3 expression, related clinical outcomes, immune infiltrates, potential mechanisms and mutations were conducted using tools including TIMER2.0, GEPIA2.0, SRING, DAVID and cBioPortal. Results showed an increased risk of high GBP3 in Brain Lower Grade Glioma (LGG) and Lung Squamous Cell Carcinoma (LUSC) and a decreased risk of GBP3 in Sarcoma (SARC) and Skin Cutaneous Melanoma (SKCM) (p ≤ 0.05). GBP3 was negatively correlated with CAFs in Esophageal Adenocarcinoma (ESCA) and positively correlated with CAFs in LGG, LUSC and TGCG (p ≤ 0.05). In addition, GBP3 was positively correlated with CD8+ T cells in Bladder Urothelial Carcinoma (BLCA), Cervical Squamous Cell Carcinoma (CESC), Kidney Renal Clear Cell Carcinoma (KIRC), SARC, SKCM, SKCM-Metastasis and Uveal Melanoma (UVM) (p ≤ 0.05). Potentially, GBP3 may participate in the homeostasis between immune and adaptive immunity in cancers. Moreover, the most frequent mutation sites of GBP3 in cancers are R151Q/* and K380N. This study would provide new insight into cancer prognosis and therapy.
China and deglobalization of the world economy
Authors: Stanojević Nataša , Zakić Katarina
Published: March 2023

This paper analyses the causes of the downward trend in three key cohesion aspects of the world economy: international trade, foreign investment and global value chains. The paper shows that the causes of these trends are not cyclical, but structural; that is, it is the process of deglobalization of the international market, and transformation of the very foundation of the international economic system is underway. The specific aim of the study was to investigate the impact of current trends on China's economy. The question is whether the Chinese economy, which has developed due to globalization processes, will be negatively affected by reverse processes, and to what extent. To capture the short-run effect of globalization-related factors on China's economy, an autoregressive distributed lag (ARDL) model was used. For estimation of the long-run linkage, the ARDL bounds testing approach to cointegration was launched. The results of testing the short-term effects showed that the new Chinese development strategy, aimed at protecting domestic economy from external disturbances, has produced excellent results. Significant changes in the Chinese development paradigm, as based on domestic production to meet domestic demand and financed by internal resources, have led to a decrease in the share of all international indicators in the Chinese economy. This is shown by both the statistical description of changes in the globalization-related variables, and it is confirmed by the results of conducted empirical research. Testing of long-term relationships has given conflicting results, so it is not possible to identify the long-term impact with certainty. Nevertheless, the parts of bounds testing that are statistically indisputable indicate a long-term, strong cumulative impact of these variables on the Chinese economy, while the direction and intensity of the action of individual variables are unpredictable. A new paradigm enables China to take a better international position as a global investor instead of a recipient of investments, to take over growing parts of global product chains instead of being their production link and to initiate a new form of globalization in the Chinese way.
Diseño del modelo de laboratorio especializado en enfermedades de cultivos agrícolas - Laboratorio de Fitopatología a través de un caso de estudio
Authors: Calderón Moncca Milagros Genesis , Gonzáles Galván Karla Guadalupe , González Salinas Ricardo Alfonso
Published: March 2023

Los laboratorios de Fitopatología son instalaciones científico-tecnológicas de investigación y servicio al sector agrícola cuya función es de analizar, diagnosticar y brindar medidas de control para cultivos con dificultades en el proceso de su producción. El diseño arquitectónico es complejo, existiendo escasa información que sirva de guía y aporte para diseñadores, arquitectos o especialistas que se dediquen a la investigación agrícola. Siendo así, el presente artículo brinda el conocimiento detallado para la adecuada distribución y diseño del laboratorio de Fitopatología, contemplando los espacios requeridos, detalle de áreas y equipos que se utilizan; mediante un proceso secuencial a partir de la recopilación de información de actividades, criterios normativos de bioseguridad y el caso de estudio a través de la visita a la “Clínica de Diagnosis de Fitopatología y Nematologia” de la Universidad Nacional Agraria La Molina - Perú.
Combined E-Learning Course Recommender System
Authors: Talaghzi Jallal , Bellafkih Mostafa , Bennane Abdellah , Himmi Mohammed Majid , Amraouy Mohammed
Published: March 2023

In this paper, we propose learners course recommender system of the E-Dirassa platform. This system, which distinguishes between new and active learners, adopts three complementary recommendation approaches: content-based recommendation as well as course-based collaborative filtering for active learners, and static profile-based collaborative filtering for new learners. Let us also note the use of multi-criteria decision aid (MDA) techniques for the choice of the textual similarity measure to be used in the first approach of content-based recommendation.
Effects of Touch-type Online Educational Games on Learners’ Learning Motivations
Authors: Wang Meng
Published: March 2023

With the advancement of science and technology, electronic devices are more extensively popularized, and students are being exposed to touch-type online at an early age, thus promoting the digitalization of children’s education and contributing to the proliferation of learning resources. Touch-type educational games emphasize learning autonomy, integrate teaching knowledge contents with games, and highlight that when using educational games, learners can obtain immediate and real feedback and identify learning and game objectives, thereby intensifying their learning. In this study, a questionnaire regarding the effect of touch-type online game education on learners’ learning motivations was designed on the basis of educational game theory. The mediating role played by learning immersion between the two was also measured. Results show that the overall Cronbach α coefficient is 0.825, the KMO value is 0.688, and the corresponding P value of Bartlett sphericity test is 0.0. In touch-type online game education, multi-organ sensing, touch gesture, and multi-hotspot response significantly affects learners’ learning motivations. Learning immersion exerts a masking effect on teachers’ initiatives in promoting learning motivations. The proportion of touch games play during class hours has different effects on learning motivation (p=0.020<0.05). The findings are critical for investigating the effects of touch interaction models on learners’ learning motivations, developing a set of evaluation indexes for educational game learning accessibility, and perfecting their evaluation methods.
Delay-Oriented Resource Allocation for OFDMA Real-Time Mobile Broadband Services
Authors: Madi Nadim K. M. , Najim Alaa Omer
Published: March 2023

Radio Resource Management (RRM) is the key component that influences the Quality of Service (QoS) in emerging mobile systems. The harsh requirements of recent multimedia applications press on the behavior of the resource allocation model at the Medium Access Control (MAC). This, under certain conditions, deteriorates awareness of the scheduler in satisfying QoS characteristics for the diverse attending traffic flows. The trade-off between QoS metrics may be a viable remedy to this problem. However, if the tradeoff is not meticulously addressed, it definitely increases the delay beyond the allowed threshold and plummets the data rates of the involved flows. In this article, a Delay-oriented Resource Allocation (DoRA) scheduler is proposed for the downlink channel to transmit multimedia applications. The main aim of DoRA is to schedule flows of different volumes with guaranteed low delay values and acceptable throughput under harsh network conditions (i.e., high traffic load and mobility). An efficient priority weight function is formulated based on a delay-oriented rule considering the buffer delay of the diverse flows. Eventually, a greedy algorithm assigns channel resources to the prioritized flows with high weights. DoRA is compared to reference schedulers using system-level simulation over two scenarios. The performance results indicate that DoRA maintains a low end-to-end delay with robust throughput and efficient spectrum efficiency for different flow volumes over congested network states.
Reliable Fuzzy-Based Multi-Path Routing Protocol Based on Whale Optimization Algorithm to Improve QOS in 5G Networks for IOMT Applications
Authors: Farah Saad Al-Mukhtar  , Zahraa A. Jaaz  , Aws H. Hamad
Published: March 2023

The Internet of Medical Things (IoMT) faces stiff competition from the 5th Generation (5G) communication standard, which includes attributes like short and long transmission ranges, Device to Device (D2D) connectivity, low latency, and high node density. To function in the linked ecosystem, IoMT based on 5G is anticipated to have a diversity of energy and mobility. It is currently difficult to create an IoMT routing system based on 5G that maximizes energy efficiency, lowers transmission latency, and increases network lifespan. The "Quality of Services (QoS)" in 5G-based IoMT is improved by the Reliable Fuzzy-based Multi-path routing system shown in this study. The Whale Optimization Algorithm (WOA) enhances the routing protocol performance. The residual energy-based Cluster Head (CH) selection strategy rotates the CH location among nodes with greater energy levels than the others. The method chooses the following set of CHs for the network that is suitable for IoMT applications by considering initial energy, residual energy, and an ideal value of CHs. According to the simulation results, our suggested routing technique enhances QoS in comparison to current approaches.
Dynamique du couvert végétal dans la Forêt Communautaire de Sambandé au Sénégal
Authors: Faye Cheikh Tidiane , Thiaw Agnès Daba , Faye Guilgane
Published: March 2023

L'évolution de l'occupation du sol entre 1998 et 2018 dans la Forêt Communautaire de Sambandé, mise en défens en 1999 et exploitée à des fins de production de charbon de bois depuis 2007, a été appréhendée à travers des images satellitaires Landsat, une enquête ménages et des relevés floristiques collectés en 2019. Les cartographies dressées à partir des images Landsat montrent que la végétation spontanée s'est fortement reconstituée. Ce constat est partagé par la population, la part des personnes interrogées considérant que la végétation spontanée était abondante passant de 14 % pour 1998 (avant la mise en défens) à 66 % pour 2018. Cette amélioration du couvert végétal s'est traduite par une progression des savanes arbustive et arborée. Entre les deux dates, la première est passée de 43,1 à 52,1 % de la superficie de la zone d'étude et la seconde de 11,3 à 15,8 %. Dans le même temps, la savane arborée dégradée a fortement régressé, passant de 33,5 % à 14,2 % de la superficie totale. La diminution de la zone dégradée est ici la marque d'un territoire en reconstitution, d'où la concordance avec l'enquête. Toutefois les inventaires floristiques donnent une vision différente, le nombre d'individus et la diversité floristique sur les placettes n'étant pas liés par une relation simple et étroite au degré apparent de reconstitution du couvert végétal.
Heritage Studies
Authors: Albert Marie-Theres
Published: March 2023

This chapter focuses on the function of heritage studies in the role of human development and sustainable heritage protection. The chapter details the importance of sustainable heritage development and the importance of identity-building, examining their role comprehensively in conjunction with UNESCO conventions, as well as epistemological and paradigmatic reflections from studies ranging from cultural anthropology to material heritage studies. The text also focuses on developments and challenges within the field of heritage studies and the application of theoretical approaches within the study. Finally, the study reflects on the ways in which heritage, with a focus on world heritage, have developed and changed over the course of time, and possibilities to address negative developments.
E-Learning Platforms in Heritage Education
Authors: Quintela Joana A. , Palotás Gábor
Published: March 2023

The content of this chapter is based on the analysis of this triad - heritage, education, and ICTs. E-learning and m-learning make it possible to motivate students in the learning and teaching process. Working with ICT tools acquires importance with regard to the possibilities they offer for disseminating heritage, promoting historical learning and raising awareness of cultural diversity and its preservation.This document describes the planning phase for the development of building trades, an online platform that incorporates learning, involvement and autonomy of those interested in applying in diverse contexts and with diverse motivations the application of manual construction techniques, typical of traditional architecture of several European countries. The e-Academy of Building Trades - E-learning Platform of Traditional Craftsmanship is a transnational project answering the great need for new, innovative approaches in the education of craftsmanship related to traditional building methods.
Man, Mind, and Machine
Authors: M. Nirmala , Chaudhary Manne Neelima , G. Srinivas
Published: March 2023

Technology is a science to solve a problem or to simplify the tasks carried out by humans. Technology in simple words is a way of doing things. There are various benefits associated, such as communication; technologies have not only helped in making the world a smaller place by bringing people closer together, but also widened the gap between people which has come to be known as ‘virtual distance.' Since the first Industrial Revolution, manufacturing has seen advancements making manufacturing processes more sophisticated and sustainable to control effectively. Industry 5.0 enables people to transition from mass manufacturing to mass personalization as people now demand the human touch of mass personalization. Mass customization is becoming a reality, and needs fast-moving advancements in manufacturing processes, system digitization, and intelligence. This article addresses a few important dimensions of technology such as technology being treated as human extension, coevolution between humans and technology, human dependence on technology and vulnerability of mankind due to technology.
Developing a Model for the Adoption of Industrial Revolution 5.0 Among Malaysian Manufacturing SMEs for Sustainable Growth
Authors: Hussain Arsalan , Ansari Hafiz Waqas Ahmed , Nasir Hafiz , Maqbool Muhammad Qasim
Published: March 2023

Industry 5.0 was introduced in Germany, pursuing the idea of creating smart factories so that emerging technologies such as the internet of things, cloud computing, robotics systems, virtual reality, big data analytics, and additive manufacturing could produce human–equipment interfaces and cyber-physical systems that generate environmental, economic, and socially sustainable manufacturing systems. Therefore, this study effort to evolve a model for the adoption of the 5IR among Malaysian manufacturing SMEs for sustainable growth. This study proposed a research model based on the theory of innovation diffusion (DOI) and TOE. The result of this study can contribute to the realization of the Industry policy. The model itself can provide guidance to industry and policymakers to promote emerging markets growth. The study is expected to benefit regulators and the business ecosystem in understanding the challenges of implementing 5IR in Malaysia and, most importantly, for them to formulate intervention processes and programs for successful adoption.
Analyzing International Business Operations in the Post-Pandemic Era Taking Into Account Industry 5.0 Realities
Authors: Chitadze Nika
Published: March 2023

The research discusses several theoretical and practical aspects related to international business and the main tendencies the international business development in the post-pandemic period. Attention is paid to the main principles of international trade, activities of the Transnational Corporations, e-commerce, leading commercial companies in the world, cryptocurrency, and the future of international business based on industry 5.0. In this regard, there are discussed several aspects related to the possible impact of Industry 5.0 on international economic relations and business.
Journey of HR From Industry 1.0 to 5.0 and the Road Ahead
Authors: Agarwal Alpana , Mathur Poornima , Walia Sandeep
Published: March 2023

Industrial revolutions are rapidly transforming the industry and redefining the world of work. Human resource management has also been affected largely by the industrial revolutions. So far, four industrial revolutions have been implemented. Each revolution came with certain positive and negative changes. For example, prior to the 18th century, HR was called personnel management and was limited to hiring, training, and administration. However, with these major revolutions in the industry, HR is now considered a business driver and includes a wide range of strategic activities. Now, discussions are going about the fifth industrial revolution. This chapter aims to elaborate on the changing business scenario, transition from industry 1.0 to 5.0, and its impact on HR. It is expected that the outcomes of the chapter will help the researchers and practitioners in understanding the technicalities and issues involved.
Chronic prostatitis and related psychological problems. Which came first: The chicken or the egg? A systematic review
Authors: Stamatiou Konstantinos , Trinchieri Margherita , Trinchieri Martina , Perletti Gianpaolo , Magri Vittorio
Published: March 2023

Introduction/Aim: A spectrum of psychological problems is commonly found in CP/CPPS patients, though it is not yet clear whether, a priori, psychological dysfunctions are the cause of these pain syndromes, or whether these pain conditions are themselves causing psychological disturbances. In this article we present the current perspective on the impact of psychological problems in chronic prostatitis syndromes and we discuss the implications thereof from a clinical perspective.

Materials and Methods: A database and a manual search were conducted in the MEDLINE database of the National Library of Medicine, EMBASE, and other libraries using the key words “prostatitis syndromes”, “chronic bacterial prostatitis”, “chronic pelvic pain”, in various combinations with the terms “psychological issues”, “depression” “anxiety”, “stress”, “unhappiness”, “cognitive status” and “personality”. Two independent reviewers performed data extraction. We included clinical studies with available information on chronic prostatitis and related psychological conditions. We considered full-text written papers. We excluded reviews and case reports. In order to reduce the risk of bias we analyzed only studies including patients with confirmed CBP or CP/CPPS. Bibliographic information in the selected publications was checked for relevant records not included in the initial search.
Results: Database search allowed us to retrieve 638 studies to which we added to 16 additional studies retrieved by hand-searching. After screening, 34 relevant papers were identified for thorough review. Most studies included patients with chronic pelvic pain and prostatitis-like symptoms, whereas a smaller number of studies included patients with methodologically con- firmed CP/CPPS including studies with a microbiologically confirmed diagnosis of CBP. The psychosocial factors examined in the selected studies include pain, catastrophizing, stress, personality factors and social aspects. Comorbid psychiatric disorders evidenced in the studies included depression, anxiety and trauma-related disorders, somatization disorders, and substance abuse. Some studies investigated the association of pain with each individual psychological disturbance, while others examined the impact of pain in association with the overall quality of life. Sample size, study design and diagnostic measures varied among studies.
Conclusions: Despite limitations and variations in sample size, study design and diagnostic measures in all included studies, a relation between chronic prostatitis and psychological problems is a consistent finding. The existing evidence does not permit to definitely conclude whether psychological problems are a risk factor for CP/CPPS or whether they represent an array of symptoms that are associated with the exacerbation of this disease.
The vicious cycle of physical inactivity, fatigue and kinesiophobia in patients with fibromyalgia syndrome
Authors: Cigdem Karacay B. , Sahbaz T. , Medin Ceylan C.
Published: March 2023

This study aims to determine the association between fatigue, kinesiophobia, disease severity, and physical inactivity by comparing fibromyalgia syndrome (FMS) patients with healthy controls. Pain and fatigue are significant barriers to the participation in functional activities. Inactivity is a result of fatigue, but exercise is the foundation of FMS treatment. This case-control study included a total of 203 participants (107 patients with FMS and 96 healthy volunteers). The fibromyalgia impact questionnaire, the fatigue severity scale, the international physical activity questionnaire, and the Tampa scale for kinesiophobia were assessed. The FMS group scored significantly higher on the fatigue severity scale and kinesiophobia than the control group (p<0.001). Significantly lower metabolic task equivalent (MET) scale values were observed in the FMS group compared to the control group (p<0.001). The severity of fatigue and kinesiophobia correlated positively with the FMS impact questionnaire (p=0.001, r=0.621) and negatively with the MET scale (p=0.009, r= –0.287). Patients with FMS experience greater fatigue, kinesiophobia, and inactivity. As the severity of FMS worsens, so do disability, kinesiophobia, and fatigue. This study highlights the importance of breaking the cycle of fatigue and inactivity in the treatment of FMS.
Emerging nailfold capillaroscopic patterns in COVID-19: from acute patients to survivors
Authors: Cutolo M. , Sulli A. , Smith V. , Gotelli E.
Published: March 2023

The SARS-CoV-2 infection causing the Coronavirus disease-19 (COVID-19) is characterized by a broad range of clinical manifestations, implicating microvascular damage with endothelial dysfunction and different organ involvement.
Bisphenol-S Influence on Oxidative Stress and Endocrine Biomarkers of Reproductive System: A Systematic Review and Meta-Analysis
Authors: Abouhamzeh Beheshteh , Zare Zohreh , Mohammadi Moslem , Moosazadeh Mahmood , Nourian Alireza
Published: March 2023

Background:

Bisphenol-S (BPS), as a new human public health concern, was introduced to the plastic industry by BPA-free labeled products following the restrictions of Bisphenol-A (BPA) as a safe alternative. However, recent research has revealed a controversial issue. In this regard, the present study aimed to review the relationship between BPS exposure and reproductive system dis/malfunction.

Methods:

PubMed and other databases were searched up to January 2021. The standard mean difference (SMD) with a 95% confidence interval (CI) was calculated for the main parameters using the random-effects model. Finally, 12 studies with 420 subjects were included in this research. Forest plot, meta-regression, and non-linear dose-response effect were calculated for each parameter by random-effects model.

Results:

Based on the results of in vitro assessment, a significant increase was found in the oxidative stress parameters, including superoxide dismutase (SMD: 0.63, 95% CI: 0.321, 0.939), thiobarbituric acid reactive substances (SMD: 0.760, 95% CI: 0.423, 1.096), and reactive oxygen species (SMD: 0.484, 95% CI: 0.132, 0.835). In addition, the hormonal assessment revealed a significant decrease in male testosterone concertation (SMD: -0.476, 95% CI: -0.881, -0.071). Moreover, in vivo examination revealed a significant decrease in hormonal parameters, such as female testosterone (SMD: -0.808, 95% CI: -1.149, -0.467), female estrogen (SMD: -2.608, 95% CI: -4.588, -0.628), female luteinizing hormone (SMD: -0.386, 95% CI: -0.682, -0.089), and female follicle-stimulating hormone (FSH) (SMD: -0.418, 95% CI: -0.716, -0.119). Besides, linear and non-linear correlations were detected in the main parameters.

Conclusion:

In conclusion, based on the current meta-analysis, BPS was suggested to be toxic for the reproductive system, similar to the other bisphenols. Moreover, a possible correlation was indicated between oxidative and hormonal status disruption induced by BPS in male and female reproductive systems dis/malfunction.
Changes in the Level of Antiphospholipid Antibodies (Anticardiolipin and Anti-β2-Glycoprotein-I) and Thromboembolic Indices in COVID-19 Patients during 3 Weeks
Authors: Haghighipour Somayeh , Salesi Mansour , Keikhaei Fereshteh , Tarrahi Mohammad J. , Khani Zahra , Salehi Hassan
Published: March 2023

Introduction:

COVID-19 is a respiratory disease caused by infection with severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). Thrombotic complications appear to be of particular importance in patients with COVID-19. This study aimed to investigate Changes in the level of Antiphospholipid antibodies (Anticardiolipin and Anti-β2-glycoprotein-I) and thromboembolic indices in COVID-19 patients during 3 weeks.

Methods:

This cross-sectional study was performed on adults with Covid-19 hospitalized at Al-Zahra Hospital in Isfahan. The case group includes the patients admitted to the internal ward or ICU who despite receiving prophylactic or anticoagulant doses suffer from thrombotic complications and the control group includes COVID-19 patients without thromboembolic events. The sample size of 120 people was considered. Anticardiolipin and anti-β2-glycoprotein-I antibodies, coagulation profiles including Fibrinogen, PTT, PT Troponin, ESR, CRP, and D-dimer were examined. After collection, the data were entered into spss24 software and analyzed.

Results:

The results showed that there was no statistically significant difference in the changes of anticardiolipin and anti-beta-2 glycoprotein in IgM and IgG as well as in the changes of ESR, CRP, PTT, PT, and fibrinogen in the two groups (P > 0.05).

Conclusions:

Our study showed that there was no statistically significant relationship between anti-phospholipid antibodies (anticardiolipin and anti-beta-2 glycoprotein) and thromboembolic events. Therefore anticardiolipin and anti-beta-2 glycoprotein is probably the puzzles causing thrombosis in COVID-19 patients, and other inflammatory responses should be examined among the cases.
Management of hypertrophic rhinitis by application of Kadali kshara
Authors: Anjali A. , Sivabalaji K. , Ashwini B. N.
Published: March 2023

Nasal obstruction is a predominant symptom in hypertrophied inferior turbinate. It can be understood as Nasanaha (~nasal obstruction) in Ayurveda. Even though there are many conditions of the nose causing nasal blockage; inferior turbinate hypertrophy which is a cardinal feature in hypertrophic rhinitis is one of the most common causes of anatomical nasal obstruction, the others being internal nasal valve stenosis and septal deviation. The turbinate hypertrophy in this condition can be managed medically using nasal decongestants and corticosteroids and it can be also managed surgically. Continuous use of nasal decongestants can cause rebound congestion. Surgical management also has limitations such as synechiae formation and postoperative bleeding. Kshara pratisarana (~external application of alkali), which is one among the types of parasurgical procedures explained in Ayurveda, can be used effectively in this condition. Moreover, nasal obstruction is one of the most common symptoms presented to an otorhinolaryngologist and it badly affects the quality of life of the patient. The present case report is a case of a 24-year-old female who was unable to sleep properly due to severe nasal obstruction and chronic rhinitis along with hypertrophy of both inferior turbinates. This also affected her studies badly. She also complains of thick nasal discharge along with obstruction. The patient had the complaints for two years but the symptoms became more severe during the past six months. On anterior rhinoscopic examination using Thudicum's nasal speculum, the presence of bilateral inferior turbinate hypertrophy was observed. The patient was treated with Pratisarana of Kadali kshara (~alkali of Musa paradisiaca Linn.) along with Sigrusimhyadi taila nasya. The treatment was effective in the present case with no recurrence during a follow-up period of 30 days. This case report revealed that nasal obstruction, which is a common problem seen nowadays can be managed effectively using Ayurvedic intervention.
Management of Levetiracetam induced anxiety disorder (Chittodwega) using Gorakhmundi (Sphaeranthus indicus Linn) Ghana vati
Authors: Joshi Sumedh Sanjay , Bhide Bhargav Vijay , Nesari Tanuja Manoj
Published: March 2023

With an exponential rise in population and subsequently intensified socioeconomic stress, the incidence of mental health disorders like anxiety possess a significant great health burden on society. Levetiracetam is an antiepileptic drug indicated in the management of partial-onset, tonic myoclonic, and tonic-clonic seizures. However, it is associated with severe adverse drug reactions such as psychosis, anxiety, suicide, and allergic reactions. The presenting symptoms of anxiety disorder can be identified as Chittodwega (~anxiety), which is a Manasa vikara (~psychological disorder) in the context of Ayurveda. This case report shows the effect of the Ayurvedic drug Gorakhmundi in relieving the symptoms of anxiety in Levetiracetam-induced anxiety. A 50-year-old female patient who is a known case of seizures presented to the outpatient department with symptoms of anxiety. The patient was diagnosed with levetiracetam-induced anxiety and was suffering from heaviness in the head, palpitation, irritability, tingling sensation in extremities, irrational fear, diminished sleep, and intermittent gastrointestinal disturbances. The patient assessment was done on the basis of the Hamilton Anxiety Rating Scale (HAM-A) and Manasa bhava parikshana (~assessment of psychological parameters) according to the principles of Ayurveda. The patient was treated with Gorakhmundi ghana vati (500 mg) twice a day for two months. The patient showed complete remission of symptoms after two months of treatment. A significant change was observed in pre- and post therapy assessment through the HAM-A and Manasa bhava parikshana. The case report highlights the effective use of Ayurveda treatment for the management of drug-induced anxiety disorder in an epileptic patient.
Ayurvedic management of vitiligo
Authors: Kataria Amit , Sunaina  , Dhiman Monica
Published: March 2023

Vitiligo is a kind of skin disease characterized by white hypopigmented patches. Although this disorder is not life-threatening, but has a serious cosmetic problem that affects the individual's emotional, psychological, and social well-being. A nine-year-old female child was diagnosed with Shvitra (~vitiligo) two years back who was presented with complaints of increasing area and number of depigmented patches of skin. She has taken PUVA (~Psoralen Plus Ultraviolet A), a type of radiation treatment, and corticosteroids but found no result. Then, an Ayurvedic treatment protocol was designed based on the signs and symptoms. The protocol includes Samshodhana (~eliminative) and Prashamana (~palliative) therapies with a combination of powdered herbal drugs having Raktaprasadaka (~improves the quality of blood), Raktashodhana (~blood purification), and Tridoshahara (~balances three regulatory functional factors of the body) action along with Bakuchi taila (~Psoralea corylifolia L.) for local application. The treatment protocol was found to be effective in the restoration of skin color.
The Evaluation of the Relationship between Changes in Masseter Muscle Thickness and Tooth Clenching Habits of Bruxism Patients Treated with Botulinum Toxin A
Authors: Erdil Deniz , Bagis Nilsun , Eren Hakan , Camgoz Melike , Orhan Kaan
Published: March 2023

Background:

Bruxism is defined as recurrent masticatory muscle activity. Although there is not an agreed treatment method for bruxism, the application of botulinum toxin A (BT-A) has become a reliable lately. This study aimed to evaluate the correlation between the changes in masseter muscle thickness and clenching habits in bruxism patients treated with BT-A.

Methods:

Twenty-five patients, 23 females and 2 males, diagnosed with possible sleep bruxism were included in the study. The Fonseca Anamnestic Index was applied to the patients to determine their clenching habits and depression levels both before the treatment, and 6 months after it. The masseter muscle thickness was measured using ultrasonography before the treatment and 3 months and 6 months after the treatment. All the patients were injected with a total of 50 U of BT-A, 25 U to each masseter.

Results:

A statistically significant decrease in masseter muscle thickness was observed in the ultrasonography 3 and 6 months after the BT-A treatment. There was a statistically significant decrease in the Fonseca scores, in which the teeth clenching habits of the patients were evaluated 6 months after the treatment. Although there was a decrease in the depression levels of the patients 6 months after the treatment, this difference was not statistically significant.

Conclusion:

When the results of this study were evaluated, it was seen that the BT-A injections are an effective, safe, and side effect-free method in the treatment of bruxism and masseter hypertrophy.
Asymptotic property C of the wreath product $\mathbb Z \wr \mathbb Z$
Authors: Zhu Jingming , Wu Yan
Published: March 2023

Using the relationship between transfinite asymptotic dimension and asymptotic property C, we obtain that the wreath product

\mathbb Z \wr\mathbb Z

has asymptotic property C. Specifically, we prove that the transfinite asymptotic dimension of the wreath product

\mathbb Z \wr\mathbb Z

does not exceed

\omega+1

.
Chronic obstructive pulmonary disease mortality trends in Spain, 1980-2020
Authors: Cayuela Lucia , López-Campos José Luis , Gaeta Anna Michela , Reinoso-Arija Rocio , Cayuela Aurelio
Published: March 2023

OBJECTIVES: In Spain, there has been a recent increase in the mortality rate for chronic obstructive pulmonary disease (COPD) in younger women. This study aimed to analyze trends in the COPD mortality rate in Spain from 1980 to 2020, evaluating any differences between genders and age groups.METHODS: Death certificates and mid-year population data were obtained from the Spanish National Institute of Statistics. For both genders, age group-specific and standardized (overall and truncated) rates were calculated by the direct method using the world standard population. The data were analyzed using the joinpoint regression method.RESULTS: In both men and women, the number of COPD deaths increased from 1980 to 1999 (average annual increase of 7% in men and 4% in women), while from 1999 onwards, deaths decreased by -1.0% per year in both genders. In women, there was a significant final period of increase in the 55-59 to 70-74 age groups and a slowing of the decline in the over 75 age group. Additionally, an increase in mortality for the truncated rates was observed for women between 2006 and 2020. In men under 70 years of age, there was an initial period in which death rates remained stable or significantly increased, followed by a period in which they decreased significantly.CONCLUSIONS: Our study shows age and gender differences in COPD mortality trends in Spain. Although the data show a downward trend, we have identified a worrying increase in the truncated rates in women for the last few years.
Classification of Image Files of Lung X-Ray Results with Architecture Convolution Neural Network (CNN)
Authors: Bakti Indra , Firdaus Mohamad
Published: March 2023

In the last decade, the use of artificial intelligence (AI) is increasing, Convolution Neural Network (CNN) architecture as one of them has helped the world to process Big Data (big data), by conducting a training process from a large number of image datasets, and then being able to learn its characteristics and then select according to its classification. The use of the python programming language as a means to classify an image file with CNN architecture is very good and has very high accuracy. Keras is a module that has been prepared by python programming language developers to support self-learning artificial intelligence that also supports CNN architecture. In CNN programming with python language, it is mentioned that the more parameters are tested, the better the artificial intelligence gives output. Therefore, the objective this test is to prove whether the more parameters given to the system can provide better output with the method used is to provide input dataset training. The results of the study can be from the number of parameters learned 1,059,106 with an average time of 135 ms, then the machine can classify the image correctly by 87.88%. if the machine learns with more parameters of 3,824,486 with an average time of 780 ms, then the machine can guess close to 100%. The results of the study can be seen that the more the machine learns with its artificial intelligence capabilities, the more proficient the machine will be.
Strongly Continuous Domains
Authors: Song Yinglong , Yang Jinbo
Published: March 2023

Strong Scott topology introduced by X. Xu and D. Zhao is a kind of new topology which is finer than upper topology and coarser than Scott topology. Inspired by the topological characterizations of continuous domains and hypercontinuous domains, we introduce the concept of strongly continuous domains and investigate some properties of strongly continuous domains. In particular, we give the definition of strong way-below relation and obtain a characterization of strongly continuous domains via the strong way-below relation. We prove that the strong way-below relation on a strongly continuous domain satisfies the interpolation property, and clarify the relationship between strongly continuous domains and continuous domains, and the relationship between strongly continuous domains and hypercontinuous domains. We discuss the properties of strong Scott topology and strong Lawson topology, which is the common refinement of the strong Scott topology and the lower topology, on a strongly continuous domain.

Comment: 10 pages, 2 figures
$SI_2$-quasicontinuous spaces
Authors: Ruan Xiaojun , Xu Xiaoquan
Published: March 2023

In this paper, as a common generalization of $SI_{2}$-continuous spaces and $s_{2}$-quasicontinuous posets, we introduce the concepts of $SI_{2}$-quasicontinuous spaces and $\mathcal{GD}$-convergence of nets for arbitrary topological spaces by the cuts. Some characterizations of $SI_{2}$-quasicontinuity of spaces are given. The main results are: (1) a space is $SI_{2}$-quasicontinuous if and only if its weakly irreducible topology is hypercontinuous under inclusion order; (2) A $T_{0}$ space $X$ is $SI_{2}$-quasicontinuous if and only if the $\mathcal{GD}$-convergence in $X$ is topological.
A Hofmann-Mislove theorem for $c$-well-filtered spaces
Authors: Zhang Liping , Zhou Xiangnan , Li Qingguo
Published: March 2023

The Hofmann-Mislove theorem states that in a sober space, the nonempty Scott open filters of its open set lattice correspond bijectively to its compacts saturated sets. In this paper, the concept of $c$-well-filtered spaces is introduced. We show that a retract of a $c$-well-filtered space is $c$-well-filtered and a locally Lindel\"{o}f and $c$-well-filtered $P$-space is countably sober. In particular, we obtain a Hofmann-Mislove theorem for $c$-well-filtered spaces.