bluuebunny/crossref_metadata_2025 huggingface dataset:
mtDNA Single Nucleotide Variants Associated with Type 2 Diabetes
Authors: García Gaona Enrique , García Gregorio Alheli , García Jimenez Camila , López-Olaiz Mildred Alejandra , Mendoza-Ramírez Paola , Fernandez-Guzman Daniel , Pillado Sánchez Rolando Alberto , Soto Pacheco Axel David , Zuñiga Laura Yareni , Sánchez-Parada María Guadalupe , González Santiago Ana Elizabeth , Román Pintos Luis Miguel , Castañeda Arellano Rolando , Hernández-Ortega Luis Daniel , Mercado-Sesma Arieh Roldán , Orozco-Luna Felipe de Jesús , Villa Angulo Carlos , Villa Angulo Rafael , Baptista-Rosas Raúl C.
Published: September 2023

Type 2 diabetes (T2D) is a chronic systemic disease with a complex etiology, characterized by insulin resistance and mitochondrial dysfunction in various cell tissues. To explore this relationship, we conducted a secondary analysis of complete mtDNA sequences from 1,261 T2D patients and 1,105 control individuals. Our findings revealed significant associations between certain single nucleotide polymorphisms (SNPs) and T2D. Notably, the variants m.1438A>G (controls: 32 [27.6%], T2D: 84 [72.4%]; OR: 2.46; 95%CI: 1.64-3.78; p<0.001), m.14766C>T (controls: 498 [36.9%], T2D: 853 [63.1%]; OR: 2.57, 95%CI: 2.18-3.04, p<0.001), and m.16519T>C (controls: 363 [43.4%], T2D: 474 [56.6%]; OR: 1.24, 95%CI: 1.05-1.47, p=0.012) were significantly associated with diabetes probability. The variant m.16189T>C Previously reported in multiple studies in different populations, it was not found to be associated with T2D in our analysis (controls: 148 [13.39] T2D: 171 [13.56%]; OR: 1.03; 95%CI: 0.815-1.31,; p=0.83). These results provide evidence suggesting a link between some mtDNA polymorphisms and T2D, probably related to association rules and topological patterns and three-dimensional confirmation associated to regions where the changes are, rather than to point mutations in the sequence.
Transcriptome and Physiological Analysis of Rapeseed Tolerance to Post-flowering Temperature Increase
Authors: Canales Javier , Verdejo José , Calderini Daniel F.
Published: September 2023

Climate change-induced temperature fluctuations pose a significant threat to crop production, particularly in the Southern Hemisphere. This study investigates the transcriptome and physiological responses of rapeseed to post-flowering temperature increases, providing valuable insights into the molecular mechanisms underlying rapeseed tolerance to heat stress. Two rapeseed genotypes, Lumen and Solar, were assessed under control and heat stress conditions in field experiments conducted in Valdivia, Chile. Results showed that seed yield and seed number were negatively affected by heat stress, with genotype-specific responses. Lumen exhibited a 9.3% average seed yield reduction, while Solar showed a 28.7% reduction. RNA-seq analysis of siliques and seeds revealed tissue-specific responses to heat stress, with siliques being more sensitive to temperature stress. Hierarchical clustering analysis identified distinct gene clusters reflecting different aspects of heat stress adaptation in siliques, with a role for protein folding in maintaining silique development and seed quality under high temperature conditions. In seeds, three distinct patterns of heat-responsive gene expression were observed, with genes involved in protein folding and response to heat showing genotype-specific expression. Gene coexpression network analysis revealed major modules for rapeseed yield and quality, as well as the trade-off between seed number and seed weight. Overall, this study contributes to understanding the molecular mechanisms underlying rapeseed tolerance to heat stress and can inform crop improvement strategies targeting yield optimization under changing environmental conditions.
Tumor Cell Resistance to the Inhibition of BRAF and MEK1/2
Authors: Chen Wenjing , Park Jong-In
Published: September 2023

BRAF is one of the most frequently mutated oncogenes, with an overall frequency of about 50%. Targeting BRAF and its effector mitogen-activated protein kinase kinase 1/2 (MEK1/2) is now a key therapeutic strategy for BRAF-mutant tumors, and therapies based on dual BRAF/MEK inhibition showed significant efficacy in a broad spectrum of BRAF tumors. Nonetheless, BRAF/MEK inhibition therapy is not always effective for BRAF tumor suppression, and significant challenges remain to improve its clinical outcomes. First, certain BRAF tumors have an intrinsic ability to rapidly adapt to the presence of BRAF and MEK1/2 inhibitors by bypassing drug effects via rewired signaling, metabolic, and regulatory networks. Second, almost all tumors initially responsive to BRAF and MEK1/2 inhibitors eventually acquire therapy resistance via an additional genetic or epigenetic alteration(s). Overcoming these challenges requires identifying the molecular mechanism underlying tumor cell resistance to BRAF and MEK inhibitors and analyzing their specificity in different BRAF tumors. This review aims to update this information.
Artificial Intelligence & Sensor Innovations— Enhancing Livestock Welfare with a Human-Centric Approach
Authors: Neethirajan Suresh
Published: September 2023

In the wake of rapid advancements in artificial intelligence (AI) and sensor technologies, a new horizon of possibilities has emerged across diverse sectors. Livestock farming, a domain often sidelined in conventional AI discussions, stands at the cusp of this transformative wave. This paper delves into the profound potential of AI and sensor innovations in reshaping animal welfare in livestock farming, with a pronounced emphasis on a human-centric paradigm. Central to our discourse is the symbiotic interplay between cutting-edge technology and human expertise. While AI and sensor mechanisms offer real-time, comprehensive, and objective insights into animal welfare, it's the farmer's intrinsic knowledge of their livestock and environment that should steer these technological strides. We champion the notion of technology as an enhancer of farmers' innate capabilities, not a substitute. Our manuscript sheds light on: Objective Animal Welfare Indicators: An exhaustive exploration of health, behavioral, and physiological metrics, underscoring AI's prowess in delivering precise, timely, and objective evaluations. Farmer-Centric Approach: A focus on the pivotal role of farmers in the adept adoption and judicious utilization of AI and sensor technologies, coupled with discussions on crafting intuitive, pragmatic, and cost-effective solutions tailored to farmers' distinct needs. Ethical and Social Implications: A discerning scrutiny of the digital metamorphosis in farming, encompassing facets like animal privacy, data safeguarding, responsible AI deployment, and potential technological access disparities. Future Pathways: Advocacy for principled technology design, unambiguous responsible use guidelines, and fair technology access, all echoing the fundamental principles of human-centric computing and analytics. In essence, our paper furnishes pioneering insights at the crossroads of farming, animal welfare, technology, and ethics. It presents a rejuvenated perspective, bridging the chasm between technological advancements and their human beneficiaries, resonating seamlessly with the ethos of the Human-Centric Intelligent Systems journal. This comprehensive analysis thus marks a significant stride in the burgeoning domain of human-centric intelligent systems, especially within the digital livestock farming landscape, fostering a harmonious coexistence of technology, animals, and humans.
Evolutionary Conservation of Five Pax6 Homologs under Strong Purifying Selection in the Horseshoe Crab Species Cluster
Authors: Dakarapu Tanay , Friedrich Markus
Published: September 2023

Horseshoe crabs represent the most ancestral chelicerate lineage characterized by marine ecology and the possession of lateral compound eyes. While considered living fossils, recent studies reported an unusual number of Pax6 transcription factor genes in the Atlantic horseshoe crab Limulus polyphemus. Pax genes encode a family of ancient metazoan transcription factors, which comprise seven subfamilies. Among these, the members of the Pax6 subfamily confer critical functions in the development of the head, the visual system, and further body plan components. Arthropods are characterized by two Pax6 subfamily homologs that were discovered in Drosophila and named eyeless (ey) and twin of eyeless (toy). However, whole genome sequence searches uncovered three homologs of ey and two homologs of toy in L. polyphemus. These numbers are explained by the occurrence of three whole genome duplications (WGD) in the lineage to the last common ancestor of L. polyphemus and its closely related three additional members of the extant horseshoe crab species cluster. Here we report comparative sequence evidence for the functional conservation of the five L. polyphemus Pax6 transcription factor homologs. Our analyses reveal that all paralogs are conserved in the approximately 135 million-year-old horseshoe crab species cluster and that they evolve under strong purifying selection. These findings identify subfunctionalization as the likeliest post-WGD outcome for the five Pax6 homologs. While awaiting confirmation by gene expression studies, this scenario would reconcile the discrepancy between the WGD-expanded gene repertoires and phenotypic stasis in the horseshoe crabs.
In-Situ Alteration of the Hydro-Mechanical Behaviour of a Compacted Stabilised Expansive Soil
Authors: Chabrat Nicolas , Cuisinier Olivier , Masrouri Farimah
Published: September 2023

This paper assesses the performance of an embankment constructed in 2010 with a stabilised expansive soil. Two types of treatment were employed at construction time: 4% lime and a mix of 2% lime and 3% cement. A sampling campaign was carried out in 2021 to evaluate the long-term performance of the stabilised soil properties. To assess the compressibility of the soil, oedometer tests were carried out on samples from different parts of the embankment. The results were compared to the compression curve of the untreated soil, also sampled in the same embankment. Complementary shrinkage tests were performed to investigate the effect of the treatment on swelling and shrinkage. The obtained results showed that the behaviour of the material from the outer part was similar to the mechanical performance of the untreated soil, demonstrating strong alteration in the effect of both treatments over time. This alteration was noticeable to a distance of approximately two metres from the external surface. Beyond this distance, the performance of the soil was comparable to the behaviour of recently treated soil. These observations, similar for each treatment dosage, raise questions as to the durability of the treatment on the outer part of the backfill.
Intelligent Tapping Machine: Tap Geometry Inspection
Authors: Lin En-Yu , CHEN RU-JIN , Lien Jenn-Jier James
Published: September 2023

Currently, the majority of industrial metal processing involves the use of taps for cutting. However, existing tap machines require relocation to specialized inspection stations and only assess the con-dition of the cutting edges for defects. They do not evaluate the quality of the cutting angles and the amount of removed material. Machine vision, a key component of smart manufacturing, is com-monly used for visual inspection. Taps are employed for processing various materials. Traditional tap replacement relies on the technician's accumulated empirical experience to determine the ser-vice life of the tap. Typically, inspecting tooth wear involves removing the tap and evaluating the degree of wear to determine if regrinding or replacement is necessary. Therefore, we propose the use of visual inspection of the tap's external features to determine whether replacement or regrinding is needed. We examined the bearing surface of the tap and utilized single images to identify the cutting angle, clearance angle, and cone angles. By inspecting the side of the tap, we calculated the wear of each cusp. We further investigated whether the cutting portion affected the length of the tool by measuring changes in tooth surface area and the amount of removed thread. This inspection process can facilitate the development of a tap life system, allowing for the estimation of the durability and wear of taps and nuts made of different materials. Statistical analysis can be employed to predict the lifespan of taps in production lines.
Machine Learning–Based Regression Models for Steel Furnace Automation
Authors: Calix Ricardo , Ugarte Orlando , Okosun Tyamo , Wang Hong
Published: September 2023

Computational Fluid Dynamics (CFD)-based simulation has been the traditional way to model complex industrial systems and processes. One very large and complex industrial system that has benefited from CFD-based simulations is the steel blast furnace. The problem with the CFD-based simulation approach is that it tends to be very slow to generate data. The CFD-only approach may not be fast enough for use in real-time decision-making. To address this issue, in this work, the authors propose the use of machine learning techniques to train and test models based on data generated via CFD simulation. Regression models based on neural networks are compared to tree boosting models. In particular, several areas (tuyere, raceway, and shaft) of the blast furnace are modeled using these approaches. The results of the model training and testing are presented and discussed. The obtained R2 metrics are, in general, very high. The results look promising and may help to improve the efficiency of operator and process engineer decision-making when running a blast furnace.
Slow Rotation of Coaxial Slip Colloidal Spheres about Their Axis
Authors: Tsai Min J. , Keh Huan J.
Published: September 2023

The flow field around a straight chain of multiple slip spherical particles rotating steadily in an incompressible Newtonian fluid about their line of centers is analyzed at low Reynolds numbers. The particles may vary in radius, slip coefficient, and angular velocity, and they are permitted to be unevenly spaced. Through the use of a boundary collocation method, the Stokes equation governing the fluid flow is solved semi-analytically. The interaction effects among the particles are found to be noteworthy under appropriate conditions. For the rotation of two spheres, our collocation results for their hydrodynamic torques are in good agreement with the analytical asymptotic solution in the literature obtained by using a method of twin multipole expansions. For the rotation of three spheres, the particle interaction effect indicates that the existence of the third particle can influence the torques exerted on the other two particles noticeably. The interaction effect is stronger on the smaller or less slippery particles than on the larger or more slippery ones. Torque results for the rotation of chains of many particles visibly show the shielding effect among the particles.
Effect of Globose Scale (Sphaerolecanium prunastri) Infestation on the Growth of Wild Apricot (Prunus armeniaca) Trees
Authors: Linghu Wei , Lu Zhaozhi , Wang Yuli , Gao Guizhen
Published: September 2023

The globose scale (GS) (Sphaerolecanium prunastri Boyer de Fonscolombe) is a sucking insect that feeds on saps of wild apricot tree (Prunus armeniaca L.) in the Xinjiang Uygur Autonomous Region of northwestern China. It feeds on branches of wild apricot leading to poor growth, leaf yellowing and leaf drop, and sometimes mortality. Since the initial infestation in 2018, all the main valleys of wild apricot trees have been affected, but there is little research on the host’s physiological response to GS infestation. We measured the differences in growth between infested and non-infested wild apricots. The results showed that the diameter of shoot branches, the fresh weight, dry weight, length, width, area, and chlorophyll content of leaves, and the longitudinal diameter of fruit, were all significantly less for infested wild apricot trees than for un-infested wild apricot. The branch length of shoots, cross diameter, and weight of fruit also decreased, although the differences were not significant. Overall, GS infestation significantly reduced the growth of wild apricot trees, and may accelerate the damage by GS to wild apricot over time.
NOBEL-BOX: Development of A Low-cost Ship-Based Instrument for Ocean Monitoring
Authors: Purba Noir P. , Faizal Ibnu , Martasuganda Marine K , Wulandari Ajeng , Kusuma Rd. Salsa D. , Ilmi Muhammad H. , Febriani Choerunnissa , Alfarez Raffy R. , Argeta Fickry , Wicaksana Jati S.
Published: September 2023

This research aims to develop an inexpensive ocean observation instrument with a project name is NOBEL (Nusantara Oceanography Backdoor Experiment Laboratory)-BOX. The device can be installed on all types of vessels and placed in a specific area to map the water conditions, providing accurate data for managing a marine area specifically to water quality. The principle of NOBEL-BOX is to attach sensors in a container connected to a microcontroller and then measure directly. The method employed includes experimental design, laboratory and field tests, and data evaluation to produce the necessary system and instruments. The design process involves the construction of the instrument and the fabrication of the device. This process includes creating three-dimensional sketches/drawings, designing microcontrollers and data transmission systems, and power capacity. The sensors attached to this device are surface water temperature, air temperature, salinity, dissolved oxygen, pH, and TDS. The testing phase includes data validation, testing of the device in the laboratory, and field testing. The laboratory and field tests showed that the device worked and provided data that can be used to analyze the seawater condition spatially and over time.
Adaptive Synthesized Control for Solving The Optimal Control Problem
Authors: Diveev Askhat , Shmalko Elizaveta
Published: September 2023

The development of artificial intelligence systems assumes that a machine can independently generate an algorithm of actions or a control system to solve the tasks. To do this, the machine must have a formal description of the problem and possess computational methods for solving it. The article deals with the problem of optimal control, which is the main task in the development of control systems, insofar as all systems being developed must be optimal from the point of view of a certain criterion. However, there are certain difficulties in implementing the resulting optimal control modes. The paper considers an extended formulation of the optimal control problem, which implies the creation of such systems that would have the necessary properties for its practical implementation. To solve it, an adaptive synthesized optimal control approach based on the use of numerical methods of machine learning is proposed. The method moves the control object, optimally changing the position of the stable equilibrium point in the presence of some initial position uncertainty. As a result, from all possible synthesized controls, he chooses one that is less sensitive to changes in the initial states. As an example, the optimal control problem of quadcopter with complex phase constraints is considered. To solve this problem? according to the proposed approach, the control synthesis problem is firstly solved to obtain a stable equilibrium point in the state space by a machine learning method of symbolic regression. After that optimal positions of the stable equilibrium point are searched according to source functional from the optimal control problem by particle swarm optimization algorithm. It is shown that such approach allows generating the control system automatically by computer basing on the formal statement of the problem and then directly implementing it onboard as far as they have already had a stabilization system inserted.
Altered Expression of Vitamin D Metabolism Genes and Circulating MicroRNAs in PBMCs of Patients with Type 1 Diabetes: Their Association with Vitamin D Status and Ongoing Islet Autoimmunity
Authors: Al-nakhle Hakeemah , Mohsen Ihsan , Elnaem Bashir , Alharbi Abdullah , Alnakhli Ibtisam , Almoarfi Shareefa , Fallatah Jameela
Published: September 2023

Background: Vitamin D (VD) acts as an immunomodulator through the vitamin D receptor (VDR) located on pancreatic and immune cells, and deficiency is related to the development of T1DM. There is no clear understanding of the molecular mechanism by which VD is down-regulated in type 1 diabetes. So, we investigated whether VD metabolism genes are expressed differently in T1DM patients and whether serum VD levels are correlated with those genes. Additionally, we sought to assess whether miRNAs affect the expression of VD metabolism genes in PBMCs from patients with T1DM. The study also examines whether altered VD metabolism genes and miRNAs impact autoimmunity. Methods: Real-time PCR was used to detect the expression profile of gene encoding 1-hydroxylases (CYP27B1), 24-hydroxylases (CYP24A1), as well as related miRNAs in PBMCs of 30 individuals with T1DM and 23 non-diabetic subjects. ELISA test was used to determine VD, GAD65, and IA-2 expression. Results: CYP27B1 mRNA levels were down-regulated, while CYP24A1 levels were not changed in PBMCs T1DM patients than in those of healthy controls (CYP27B1, p = 0.0005, CYP24A1, p=0.205, respectively). has-miR-216b-5p expression was significantly up-regulated in T1DM while has-miR-216b-5p down-regulated compared to the control. The expression of CYP27B1 in T1DM subjects was not correlated with levels of has-miR-216b-5p, has-miR-21-5p, and VD. Interestingly, CYP27B1 mRNA concentrations in PBMCs of T1DM subjects correlated negatively with IA2 but not GAD65. Conclusions: We observed down-regulation of CYP27B1 mRNA levels and up-regulated has-miR-216b-5p in PBMCs of T1DM. However, CYP27B1 expression was not correlated with the expression of has-miR-216-5p and VD status, suggesting other mechanisms may regulate CYP27B1 expression.
A Direct Laser Sintering Approach for the Electrophoretic Deposition Overlay of Yttria-Stabilized Zirconia on the Surface of a Thermal Barrier Coating System
Authors: Ali Bash Maryam Abdul-Adheem , Ajeel Sami A. Ajeel Abo-alnoon , Abbas Ruqaia Abdul-Kadhim , Jasim Mohammed
Published: September 2023

The laser sintering process and modification of electrophoretic deposition (EPD) YSZ coatings on YSZ air plasma sprayed thermal barrier coatings (TBCs) were investigated. Ni-based superalloy was plasma sprayed using yttria-stabilized zirconia (YSZ) to perform thermal barrier coating with 400 μm thickness. The electrophoretic deposition (EPD) technique was used for depositing nanopowder of YSZ on the surface of YSZ TBCs. In this study, a technology of direct sintering the green EPD layer by laser beam was carried out. The best conditions of deposition YSZ overlay coating using DC current were obtained with applied voltage 40 V, deposition time 5 min, and suspension concentration 10 g/l. Iodine was added to the solutions as the stabilizing agent. To overcome the disadvantages of high sintering temperatures, laser sintering was taken as a new approach. Microstructures for all specimens were studied using Field Emission Scanning Electron Microscopy (FESEM) with EDS analysis. Surface roughness was investigated using AFM analysis and central line average (CLA). The results indicated that the morphology after the direct laser sintering of the EPD layer has a fine and controllable grain size, high hardness, and low roughness. Which is better than the direct laser on plasma-sprayed coatings.
Pengembangan Media Pembelajaran Ukur Tanah Berbasis Video Editorial TikTok untuk Kelas X DPIB
Authors: Arbi Maulana Muhammad , Sukatiman Sukatiman , Rahmawati Kundari
Published: September 2023

Penelitian ini bertujuan untuk: (1) mengembangkan media pembelajaran Ukur Tanah berbasis video editorial Tik Tok pada kelas X DPIB; (2) mengetahui tingkat kelayakan media pembelajaran Ukur Tanah berbasis video editorial TikTok. Penelitian ini merupakan penelitian Research & Development (R&D) modifikasi pengembangan Borg and Gall oleh Munawaroh. (2015) yaitu : (1) menemukan potensi masalah; (2) melakukan pengumpulan data dengan observasi dan wawancara; (3) menyusun materi untuk merancang script video dan merancang storyboard; (4) pengambilan footage berisikan materi yang dituangkan dalam video; (5) pengeditan video dengan menggabungkan footage yang terkumpul sesuai kebutuhan sehingga menjadi media pembelajaran ukur tanah editorial aplikasi TikTok; (6) melakukan validasi desain oleh ahli materi dan ahli media; (7) revisi desain dengan masukan dan saran oleh validator; (8) melakukan uji coba produk, uji coba terbatas 10 peserta didik dan uji coba luas 25 peserta didik; (9) revisi produk dari uji coba produk. Hasil pengembangan penelitian berupa media pembelajaran berbasis video editorial TikTok yang telah dipublikasikan pada aplikasi TikTok dan dapat ditonton pada komputer maupun handphone. Kelayakan media pembelajaran Ukur Tanah berbasis video editorial aplikasi TikTok berdasarkan penilaian yang dilakukan: (1) hasil penilaian ahli materi persentase kelayakan 89,7% dikategorikan sangat layak dan hasil penilaian ahli media persentase kelayakan 87,5% dikategorikan sangat layak; (2) hasil penilaian uji coba terbatas persentase kelayakan 83,8% dikategorikan sangat layak dan hasil penilaian uji coba luas persentase kelayakan 84,4% dikategorikan sangat layak. Mengacu pada hasil penilaian dapat disimpulkan bahwa media pembelajaran Ukur Tanah berbasis video editorial TikTok dinyatakan sangat layak untuk digunakan dalam pembelajaran
Occupational Health and Safety (OHS) Impact on Time and Cost of East Java'S National Road Projects
Authors: Nainggolan Boyke Mangaratua , Beatrix Michella
Published: September 2023

Road infrastructure development has increased in the last three years. Like the construction of other infrastructure projects, the implementation of this road project also carries a high risk of work accidents. Therefore, knowledge of Occupational Safety and Health (OHS) is needed to minimize the potential risk of work accidents. The purpose of this study is to determine the implementation of Occupational Safety and Health (OHS) in national road projects in East Java and review what can be done so that the implementation of Occupational Safety and Health (OHS) in national road projects in East Java can run better. This research began with data collection through the questionnaire method, distributed to the national road project head office in East Java, with the respondents being project managers or project leaders. Furthermore, the collected questionnaire data were analyzed using the Partial Least Square (PLS) method. The results of the partial least squares analysis show that the factor that most influences the application of OHS is the Management Role Factor (X2) which ranks first, with the Management Role variable having an effect of 25.07%.
Development of Plumbing Work Practice Learning Videos In the Department of Civil Engineering Education and Planning UNY
Authors: Prihadi Wisnu Rachmad , Santoso Agus , Pratomo Hasdi Nur
Published: September 2023

This research contributes to (1) developing a learning video of Plumbing and Sanitation Practice Practice, (2) knowing the feasibility of the Plumbing and Sanitation Practice Practice video learning media, (3) knowing user perceptions regarding the Plumbing and Sanitation Practice Practice learning video applied to the Department of Education UNY Civil Engineering and Planning. This research is an R&D research with a 4D model approach (Define, Design, Development, Disseminate). Data collection techniques are based on research subjects in making video products for Plumbing practice learning videos, namely experts related to plumbing materials, media experts. The instrument used uses a Likert scale to measure the feasibility level of the product being developed. The results obtained are (1) the define stage, namely analyzing the initial conditions, analyzing the character of students, analyzing concepts and learning objectives, the design stage, namely designing a script for the delivery of information consisting of opening, content, closing, the development stage, namely the process of recording making a video learning until the completion of editing the resulting video and then testing the eligibility validation of the product by experts, the disseminate stage, namely the limited dissemination of the product produced in this case the learning video of plumbing work practices to samples to assess and find out the level of feasibility and usefulness of the product; (2) the level of product feasibility based on the material content made is worth 4.58 belonging to the "very feasible" category, while the assessment based on the media made is worth 4.91 belonging to the "very feasible" category; (3) The results of the disseminate that has been carried out obtain the value of the user's perception of the product which is included in the very high category, the percentage of product feasibility is 91.52% which is included in the "Very Eligible" category.
Women-Centered Program for Women of Color (WC4WC): A Community-Based Participatory, Culturally Congruent Sexual Health Intervention in Los Angeles County, California
Authors: Wyatt Gail E. , Chin Dorothy , Loeb Tamra B. , Norwood-Scott Enricka , McEwan Jenna A. , Zhang Muyu , Smith-Clapham Amber M. , Cooley-Strickland Michele , Trinidad Cheryl , Flint Janette R. , Wells Yvette , Divinity Rosalynd , Liu Honghu
Published: September 2023

The Women-Centered Program for Women of Color, a culturally congruent sexual health intervention, was implemented in 2018 in Los Angeles County, California, according to the principles of community-based participatory research: enhancing community capacity, establishing sustainable programs, and translating research findings to community settings. Participants exhibited significantly increased knowledge of and interest in preexposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) over time, but no significant change in condom use was evident. Booster sessions are needed to maintain interest in PrEP and PEP given concerns about reproductive and sexual health. (Am J Public Health. 2023;113(S2):S110–S114. https://doi.org/10.2105/AJPH.2023.307296 )
Extending an Antiracism Lens to the Implementation of Precision Public Health Interventions
Authors: Allen Caitlin G. , Olstad Dana Lee , Kahkoska Anna R. , Guan Yue , Ramos Paula S. , Steinberg Julia , Staras Stephanie A. S. , Lumpkins Crystal Y. , Milko Laura V. , Turbitt Erin , Rahm Alanna K. , Saylor Katherine W. , Best Stephanie , Hatch Ashley , Santangelo Isabella , Roberts Megan C.
Published: September 2023

Precision public health holds promise to improve disease prevention and health promotion strategies, allowing the right intervention to be delivered to the right population at the right time.

Growing concerns underscore the potential for precision-based approaches to exacerbate health disparities by relying on biased data inputs and recapitulating existing access inequities. To achieve its full potential, precision public health must focus on addressing social and structural drivers of health and prominently incorporate equity-related concerns, particularly with respect to race and ethnicity.

In this article, we discuss how an antiracism lens could be applied to reduce health disparities and health inequities through equity-informed research, implementation, and evaluation of precision public health interventions. (Am J Public Health. 2023;113(11):1210–1218. https://doi.org/10.2105/AJPH.2023.307386 )
A Transplant or a Patch? A Review of the Biologic Integration of Meniscus Allograft Transplantation
Authors: Lichtig Asher , Bedi Asheesh , Koh Jason , Amirouche Farid
Published: September 2023

» After transplantation revascularization does occur although data are only available for animal models.

» The time zero biomechanics, that is, the biomechanical properties at the time of transplant, of a meniscus allograft transplantation appear to appropriately mimic the original so long as the graft is sized correctly within 10% of the original and bone plug fixation is used.

» Allograft type, that is, fresh vs. frozen, does not appear to affect the integration of the allograft.
NOT ENTIRELY ICHTHYOSAUR: A MYSTERIOUS LAMNIFORM AND ICHTHYOPTERYGIAN-FALL ASSOCIATION FROM THE ABYSSAL UPPER CRETACEOUS OF THE NORTHERN APENNINES (ITALY)
Authors: SERAFINI GIOVANNI , AMALFITANO JACOPO , DANISE SILVIA , MAXWELL ERIN E. , RONDELLI RICCARDO , PAPAZZONI CESARE A.
Published: September 2023

Axial remains of a large ichthyosaur and a medium-sized anacoracid shark from the deep-water sediments of the Cenomanian of the Northern Apennines (Northern Italy) are described in detail. The specimens were found closely associated (less than 0.3 m apart), and offer an invaluable window into the taphonomy and dead-fall stages of pelagic vertebrates in a Mesozoic abyssal plain. The anacoracid shark remains, initially misinterpreted as an ichthyosaur, consist of eight articulated vertebrae embedded in a block of dark arenaceous matrix, and represent the first occurrence of an articulated shark from the Northern Apennines. The ichthyosaur remains consist of seven discoidal vertebrae and several unidentified fragments. Due to the absence of diagnostic skeletal elements, both specimens are assigned only at higher taxonomic levels. The two fossils, which come from the same outcrop and possibly from the same stratigraphic horizon, share a common taphonomic history, in terms of both their preservation and diagenesis. Mineralogy of the matrices of both is dominated by manganese micro-nodules, consistent with the deposition of polymetallic nodules in bathyal-abyssal settings. Biostratinomic processes that impacted the two specimens also provide insight on the development of Mesozoic marine vertebrate-falls in the deep-sea. Localized pyrite framboids inside the bone spongiosa are possible evidence of the sulfophilic stage (microbially mediated sulfur mobilization during lipid decay) in the ichthyosaur fall. Burrows assigned to Taenidium on the surface of the shark block, interpreted as worm-like feeding burrows or arthropod locomotion and feeding trails, might represent evidence of the enrichment opportunistic stage. Although intriguing, we have no evidence to support the hypothesis that this peculiar association of two pelagic predators is due to ecological interaction between the two animals.
Parapharyngeal Acinic Cell Carcinoma: A Case Report of a Rare Extra-Parotid Occurrence
Authors: Limani Rinë , Veselaj Fahredin , Limani ZgjimLimani , Kondirolli LabinotaKondirolli , Gashi Brikenë
Published: September 2023

Parapharyngeal space (PPS) tumors are among the most challenging tumors of the head and neck region to diagnose and treat. Acinic cell carcinoma (ACC) is an extremely rare extra-parotid malignant neoplasm of the PPS. Herewith, we report a case of extra-parotid, low-grade solid pattern ACC diagnosed in a 55-year-old male who presented with a left parapharyngeal bulge. Despite its rare occurrence, ACC of the PPS should be included in the differential diagnosis of PPS tumors.
Vertical Bone Augmentation Using Two Bioactive Glasses in a Rabbit Tibia Model: A Comparative Study with Literature Review
Authors: Melkumyan Timur , Kamilov Nuritdin , Khabadze Zurab , Makeeva Maria , Seeberger Gerhard , Gevorgyan Sargis , Dadamova Angela
Published: September 2023

Background: Recently, synthetic materials based on bioactive glasses have been in special demand in dental implantology, which, according to the mechanism of their action, are not only osteo-conductors, but also osteo-inductors. Of even greater interest is the fact that the biological degradation of these materials causes alkalization of the area and inhibits the growth of many pathogens. Considering the unique properties of this group of osteoplastic fillers and the problems associated with healing after guided bone regeneration, this study aimed to compare the effectiveness of using bioactive glasses S53P4 and 45S5 when performing vertical bone augmentation in an experiment applying a rabbit tibia model. Methods and Results: Six adult outbred rabbits aged from 1.5 to 2 years and weighing from 2.5 kg to 3.2 kg were used in the study. A titanium mesh was used to perform a true vertical guided bone regeneration technique. In each animal, two titanium tents were placed: one on the left tibia and one on the right tibia. On the left limb, empty spaces were filled with bioactive synthetic bone filler NovaBone® Morsels (USA); on the right limb, we used a mixture of bioactive glass Bonalive® granules CMF (Finland) and mineralized bone MedPark Bone-D XB (Bovine Xenograft, South Korea) in a ratio of 1:1. The quantity and quality of regenerated tissues were assessed after 8-10 weeks. The NovaBone application has allowed a gain of 2.6±2.67 mm in extra-skeletal hard tissue growth. No signs of guided bone regeneration were observed in all cases of application of an osteoplastic mixture of Bonalive and Bone-D XB granules. Conclusion: Within the limits of this study, it was found that the use of a mixture of bioactive glass Bonalive (S53P4) with bovine hydroxyapatite in a 1:1 ratio was not effective in vertically guided bone regeneration, but the application of NovaBone (45S5) could promote a new bone formation.
Radiosensitization: Studies and Modern Approaches to Cellular Radiosensitivity
Authors: Alamilla-Presuel Juan
Published: September 2023

Even though radiation therapy has achieved great success, there is still an unsolved task of increasing radiation damage to tumor tissue and reducing side effects on healthy tissues. There is a wide variety of obstacles that reduce the efficiency of radiotherapy. Mechanisms of radioresistance involve tumor-specific oncogenic signalling pathways, tumor metabolism and proliferation, tumor microenvironment/hypoxia, and genomics. Radiosensitizers are promising agents that enhance injury to tumor tissue by accelerating DNA damage. Several strategies have been used recently to develop highly effective radiosensitizers with low toxicity. In this review, we considered the use of radiosensitizers, including small molecules and nanomaterials, in various malignant tumors and the problems and prospects for their clinical use in cancer therapy.
Acne Scar Management: Minoxidil as a Promising Approach or a Mirage?
Authors: Hussein Ramadan , Dayel Salman
Published: September 2023

Atrophic and hypertrophic scars can result from various conditions, such as acne, trauma, and surgery. Minoxidil, a medication used for the treatment of severe hypertension and hair loss, has been explored as a potential treatment for scars. This review aims to evaluate the current evidence regarding the role of minoxidil in the treatment of scars. Previously published reviews have primarily focused on the use of minoxidil in hair loss and have only briefly mentioned its potential use for scars. However, minoxidil may have a beneficial effect as an antifibrotic agent. Several studies have reported reduced collagen accumulation and fibrosis after treatment with minoxidil. The proposed mechanism of action is inhibition of the production of lysyl hydroxylases (LHs), which modify and cross-link proteins by converting lysine to hydroxylysine, making collagen more resistant to degradation. Minoxidil, as an LH inhibitor, has been shown to potentially benefit wound healing and regeneration in vitro by inhibiting the proliferation and migration of fibroblasts. To date, direct studies of the efficacy of minoxidil in treating acne scars have not been conducted; however, its inhibitory effects on fibroblast function and antifibrotic outcomes in some in vivo studies suggest that such use may be considered.
Exploring global patterns of trace metal limitation as a regulator of the distribution of dominant marine phytoplankton groups
Authors: Zhang Qiong , Zhou Yu , Barton Samuel , Liu Fengjie , Shafiee Roxana , Yin Kedong , Bouman Heather , Tagliabue Alessandro , Rickaby Rosalind
Published: September 2023

The availability of essential elements determines the productivity of phytoplankton, with implications for ocean carbon sequestration, but the role of multiple trace metals for driving the biogeography of key phytoplankton groups that are major components of the carbon pump is not well understood. We explore the patterns of trace metal limitation of phytoplankton species spanning across different functional groups with a novel set of approaches that combined data synthesis and diagnostic modelling. Our analysis reinforces the importance of Fe, showing that representative species of diatoms, picocyanobacteria, and dinoflagellates are Fe limited in about 60%, 38%, and 5% of the global ocean. However, diatoms are also Mn limited in ~20% and dinoflagellates Zn limited in over 60% of the ocean. Our analyses additionally highlight a previously overlooked role of Cu in limiting the growth of phytoplankton and suggest that trace metal supply may have a greater impact on the distribution of diatoms and dinoflagellates than on coccolithophores. The inferred patterns of trace metal limitation for different phytoplankton are broadly supported by transcriptomic data from surface ocean. Using projections of how trace metal concentrations may evolve with climate change, we show that the future oceans may promote widespread Zn limitation, shifting phytoplankton communities to groups that drive a weaker biological pump.
Determining Malware Attacks in Iot Health Care System Using Self Attention Based Depth Poly O (Optimized)-network
Authors: Rodrigues Paul , Bangali Harun , Basha Syed Asif , Gopalakrishnan T , V Pandimurugan , S Rajasoundaran , SVN Santhosh Kumar
Published: September 2023

The Internet of Things (IoT) is becoming more important in numerous sectors, including healthcare, industry, the military, and education. The framework successfully safeguards the privacy, authenticity, and accessibility of data in a networked setting. Health care is only one of many sectors that may benefit from the given solutions, which are essential for protecting the personal information of patients and maintaining the integrity of their medical records. The privacy, security, and reliability of the whole health care system online are still at danger owing to a broad variety of intermediary assaults and infiltration activities, despite the fact that the Internet of Things (IoT) offers trustworthy mechanisms for keeping data secure. In this research, we employ a hyper-tuned optimal classifier based on deep learning to overcome these issues. Here the real time patients sensor data are retrieved and it can be preprocessed for removing the error by using the Minmax Hat normalization. Then the features can be selected using wrapper discriminant component analysis. Then the proposed classifier can be optimized using the Hybrid CUADA (Cuckoo Adam) optimization algorithm. After classification parameter optimization, the collected features are fed into the newly-introduced self-attention based depth poly O (optimized)-Network to detect malware intrusions and monitor patient records. The system's effectiveness has been assessed based on experimental findings and subsequent discussions.
Dimensional Structure and Psychometric Properties of the Persian Version of the Existential Loneliness Questionnaire (ELQ)
Authors: hadeei sohrab , Aminikhoo Masoumeh
Published: September 2023

Background: The recent pandemic of Coronavirus and its associated excess mortality, made the man more prone to sense of isolation and of being alone existentially. Therefore, it is necessary to identify, assess, and reduce such negative feelings. The present study aims to provide a Persian adaptation of the existential loneliness questionnaire (ELQ) and to examine its dimensional structure and psychometric characteristics.
Methods: The ELQ items were translated into Persian using forward-backward translation method. Participant recruitment is conducted via social media platform and data is collected via online survey. Content validity was evaluated by the experts‘ judgement, followed by factor analysis, validity, and reliability tests. Two samples of university students were collected. Sample 1 consisted of 305 students aged 18-53 years, completed the Persian adaptation of the ELQ and several other instruments: De Jong Gierveld Loneliness Scale (DJGLS), Existential Anxiety Questionnaire (EAQ), Beck Depression Inventory (BDI-13), Meaning in Life Questionnaire (MLQ), and Satisfaction with Life Scale (SWLS). Sample 2 consisted of 262 students aged 18-50 years, completed only the Persian ELQ to conduct Confirmatory Factor Analysis (CFA) tests.
Results: According to Parallel Analysis (PA) and Exploratory Factor Analysis (EFA) results, a unidimensional structure was found for the Persian ELQ. And the results of the CFA test supported this finding. The Multi-group CFA test supported the measurement invariance of the questionnaire across two samples. Evidence of high internal consistency (α =.91) and adequate test-retest reliability (r= .73) was found as well. The correlational analyses revealed strong construct validity based on the ELQ scores‘ significant association with other criterion measures.
Conclusions: According to the findings, the Persian version of the ELQ is a reliable, valid and psychometrically suitable instrument for use in Iranian samples of university students.
A Novel Rigid-Soft Gripper for Safe and Reliable Object Handling
Authors: Trinh Xuan Hiep , Nguyen Hoang-Hai , Pham Trung-Dung , My Chu Anh
Published: September 2023

This research paper proposes a novel robotic gripper that combines the advantages of both rigid and soft grippers. The challenge of developing robotic grippers that can handle a wide variety of objects with high precision, especially under harsh vibration is addressed. The gripper uses a main rigid structure for maintaining the stiffness of therobot hand and soft pads under air pressurization for handling the softly and flexibly the objects. The novel conceptual design and structural design are introduced. The gripper design and fabrication were validated through mathematical modelling, analysis, and experimental procedures. In particular, the deformation of the soft element is estimated using numerical simulation and mathematical calculation. Based on the estimation of the soft element’s deformation, the contact forceis analysed. The experiment confirms that the proposed gripper allows for safe interaction with a variety of grasped objects while maintaining diversity and stability during gripping movement, even under harsh vibration conditions with high frequency. This gripper design can be applied for handling a wide range of objects with varying sizes, masses, fragility, and placement positions. It is particularly useful when the gripping process necessitates both safe interaction and high reliability.