bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Phenoplast-Based Structural Electrolyte with High Ionic Conductivity and Fire Resistance for Advanced Energy Storage Composites
Authors: Sha Zhao , Gao Ziyan , Shen Yingkun , Wang Cheng , Xu Jiangtao , Wu Shuying , Brown Sonya , Peng Shuhua , Zhang Jin , Wang Chun
Published: February 2025

Structural energy storage composites are a promising lightweight solution for many applications, enabling structures to store electricity. However, there is a significant challenge in engendering polymer electrolytes with high flame retardancy, ionic conductivity, and mechanical properties. In this study, we introduce a novel fire-resistant polymer electrolyte that is highly ionic conductive and mechanically strong by designing a co-continuous composite electrolyte consisting of phenolic resin (or phenoplasts), ionic liquid (EMIM TFSI), and lithium salt (LiTFSI). The ionic liquid and lithium salt work synergistically as a hybrid surfactant to facilitate the emulsion polymerization of the phenolic resin, forming unique microstructures where the Li⁺ ions complex with hydroxyl groups in the phenoplasts creates ion-conductive pathways in the solid phase. This design yields significantly enhanced ionic conductivities up to 2.87 mS/cm, comparable to those of ionic liquids. For structural electrolyte applications, certain formulations achieved an ionic conductivity of approximately 0.15 mS/cm, a tensile strength around 19 MPa, and a tensile modulus of about 1.2 GPa. These properties demonstrate a well-balanced performance between electrochemical and mechanical characteristics, making the electrolytes suitable for advanced structural energy storage applications. The resulting phenoplast-based electrolyte not only maintains mechanical strength and structural integrity but also achieves the highest flame retardancy rating of V-0. A composite structural supercapacitor fabricated using this electrolyte demonstrated excellent electrochemical performance and safety features. This development presents a significant advancement in creating safe, efficient, and multifunctional materials for advanced structural energy storage applications.
Combination and Interaction of Seven Trace Elements and the Risk of Protein-Energy Malnutrition in School-Aged Children in Shenzhen, China
Authors: Yu Mingtao , Tan Leyun , Chen Yuhui , Shang Jianhui , You Yingbin , Xie Haimin , Pang Nan , Liang Rimei , Zhang Qingying
Published: February 2025

Background
The imbalance of trace elements plays an important role in childhood malnutrition, but previous studies are usually specific to certain elements. We aimed to examine the individual and joint associations between multiple elements and the risk of protein-energy malnutrition (PEM) in young school children.
Methods
This study measured the serum levels of Zinc (Zn), Copper (Cu), Chromium (Cr), Cobalt (Co), Vanadium (V), Manganese (Mn), and Nickel (Ni) in 1832 out of 5152 children aged 6 to 9 years by using inductively coupled plasma mass spectrometry. The individual and joint association of element and risk of PEM were appraised using logistic regression, restricted cubic splines model (RCS), bayesian kernel machine regression (BKMR), and weighted quantile sum regression (WQS) model, respectively.
Results
Serum concentrations of Zn, Cu, Co, V, Mn, and Ni were significantly lower in the PEM group than in controls (all P < 0.005). Higher quartile concentrations of Zn (OR = 0.52), Cu (0.59), V (0.52), Mn (0.51), and Ni (0.68) were associated with lower PEM risk (all Ptrend < 0.05). RCS model indicated non-linear relationships between Zn, Cu, Cr, Co, V, Mn, and PEM risk. Interactions were found between Zn, Mn, and Co on the risk of PEM. Both BKMR and WQS models revealed a negative joint association of seven elements with PEM risk (OR = -0.102), Mn (40.4%), and Zn (19.1%) as the strongest contributors.
Conclusion
Serum concentrations of Zn, Cu, Co, V, and Mn were relatively lower in Children with PEM and exhibited non-linear associations with the risk of PEM. The joint association of seven trace elements was negative with the risk of PEM, in which Mn and Zn contribute the most. Additionally, Mn, Zn, and Co exhibited pairwise interactions. These findings highlight the importance of maintaining balanced trace element levels to mitigate PEM in children.
Classification and Interpretation of Histopathology Images: Leveraging Ensemble of EfficientNetV1 and EfficientNetV2 Models
Authors: Kalati Mahdi Azmoodeh , Shabani Hasti , Maghareh Mohammad Sadegh , Barzegar Zeynab , Lashgari Reza
Published: February 2025

Breast cancer is the second leading cause of cancer-related deaths among women, following lung cancer, as of 2024. Conventional cancer diagnosis relies on manual examination of biopsied tissues by pathologists which is a time-consuming process and based on pathologist experience may vary. Early detection and accurate diagnosis are critical for effective treatment planning and patient care. The invention of whole-slide scanners has revolutionized this process by enabling the adoption of Computer-Aided Detection (CAD) systems for automated analysis. Convolutional Neural Networks (CNNs) within CAD systems play a pivotal role in the automated classification of breast tissues. This study utilizes state-of-the-art CNNs called EfficientNetV1 and EfficientNetV2 for binary classification of BreakHis dataset ,a collection of histopathological images categorized as benign and malignant breast tissues. To address the challenge posed by the limited availability of annotated data, data augmentation and transfer learning techniques were applied. Model interpretability was enhanced using the Grad-CAM technique, which generates localization maps highlighting critical regions relevant to predictions. Finally, ensemble learning is employed for further improving performance. we utilized unweighted averaging and majority voting to combine predictions of multiple trained models. Furthermore, We define two ensemble architecture combining different trained EfficientNets. The proposed framework was able to achieve a classification accuracy of 99.58% outperforming conventional CNN models on BreakHis dataset. This study underscores the potential of ensemble learning to improve diagnostics accuracy in breast cancer detection.
Общественно-политические взгляды раннего Э. Бёрка(50-е – начало 60-х годов XVIII века)
Authors: Ковалев М.А.
Published: February 2025

В статье рассматриваются взгляды британского мыслителя и политика XVIII века, основателя консерватизма Эдмунда Бёрка. Автор ограничивается изучением раннего периода творчества этого мыслителя, когда он еще не вышел на широкую политическую арену. Именно в этот период Берк написал несколько значительных работ, которые заложили основу для реализации всей его дальнейшей политической перспективы. В статье также уделяется значительное внимание философским взглядам мыслителя, поскольку они легли в основу его социальных и политических идей.

The article deals with the views of the XVIIIth century British thinker and politician, founder of the ideology of conservatism Edmund Burke. The author is limited to studying the early period of creativity of this thinker when he has not yet entered the broad political arena. It was during this period that Burke wrote some of significant works that laid the foundations for all his further political outlook. The article also pays considerable attention to the philosophical views of the thinker, as they were the basis of his social and political ideas.
Valeriana alliariifolia Adams Kök Ekstresinin SH-SY5Y ve PC-12 Hücre Hatları Üzerindeki Toksik Etkilerinin Değerlendirilmesi ve Antioksidan Aktivitesinin Araştırılması
Authors: İlgün Selen , Şeker Karatoprak Gökçe
Published: February 2025

Araştırmada, Türkiye’de yetişen Valeriana alliariifolia Adams türünün köklerinden hazırlanan %80’lik etanol ekstresinin SH-SY5Y nöroblastoma ve nöron benzeri PC-12 hücre hatlarındaki toksisitesi incelenmiştir. Ekstrenin toplam fenol ve flavonoit miktarı spektrofotometrik yöntemlerle belirlenmiştir. Antioksidan aktivitesi, DPPH ve ABTS radikal süpürücü aktivite tayin yöntemleri ile analiz edilmiştir. Ekstrenin, toplam fenol içeriğinin 210.42±2.58 mgGAE/gekstre olduğu, 0.2-4 mg/mL konsantrasyon aralığında ise DPPH radikalini güçlü bir şekilde süpürebildiği belirlenmiştir. Ekstrenin düşük (3.9 ve 7.81 µg/mL) konsantrasyonlarda SH-SY5Y ve PC-12 hücreleri üzerinde toksik etki göstermediği, aynı zamanda 369.68 ± 2.61 µg/mL IC50 değeri ile PC-12 hücre hattında daha düşük toksisiteye sahip olduğu gözlenmiştir. Sonuçlar, Valeriana alliariifolia türünün yeni fitofarmasötikler ve fonksiyonel bileşenler geliştirmek için potansiyel aday olabileceğini göstermektedir.
Enhanced Luminescent Probe Utilizing Schiff Base Ligand for 2,4,6-Trinitrophenol Detection in Aqueous Media
Authors: Altun Ayhan , Buldurun Kenan , Turan Nevin
Published: February 2025

This research explored the fluorescence properties of a Schiff base ligand which was synthesized and characterized used by standard spectroscopic methods. The examination into its photophysical and fluorescent sensor properties involved UV-Vis spectroscopy, as well as fluorescence spectroscopy, time-resolved and steady-state. Fluorescent sensors were found to exhibit excellent sensitivity and selectivity for 1,3,5-trinitrophenol (TNP), over testing with other nitroaromatic (dinitrobenzene (DNB), 2,4,6-trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), 2-nitrophenol (2-NP), 4-nitrophenol (4-NP), and 2,4-dinitrophenol (DNP)), explosives with significant fluorescence “off” responses, resulting in immediate fluorescence color change. The binding mechanisms between Schiff base and TNP were assessed using Job’s drawing. The compound exhibited exceptional sensitivity in detecting TNP with an impressively low LOD of 0.253 μM covering a linear working range of 2.50-30.00 μM. The study revealed that the compound exhibited robust fluorescent properties, proved to be effective in fluorescence quenching-based TNP detection in water solutions, and demonstrated both high selectivity and sensitivity. This finding underlines the potential utility of this ligand as a promising tool in environmental monitoring or related fields where the detection of TNP is crucial.
Horozibiği (Amaranthus Albus L.) Bitkisinde Putresin Uygulamasının Bazı Fizyolojik ve Biyokimyasal Parametreler Üzerine Etkisi
Authors: Toprak Tülay , Tunçtürk Rüveyde , Tunçtürk Murat
Published: February 2025

Bu çalışma; insan gıdası, kaba yem ve yağı için yetiştirilen ve son yıllarda üzerinde yoğun araştırmalar yapılan horoz ibiği (Amaranthus albus L.) bitkisinde putresin uygulamalarının bazı fizyolojik parametreler üzerine etkilerini belirlemek amacıyla yürütülmüştür. Çalışma 2022 yılında Van YYÜ Ziraat Fakültesi Tarla Bitkileri Bölümü’ ne ait tam kontrollü iklim odasında Tesadüf Parselleri Deneme Deseni’ ne göre faktöriyel düzende kurulmuştur. Dört tekerrürlü olarak kurulan denemede horoz ibiği bitkisi ve 4 farklı putresin dozu (0, 50, 100 ve 150 mM) kullanılmıştır. Araştırmada, toplam antioksidan aktivite, toplam fenolik madde, toplam flavonoid madde, askorbik asit, toplam karotenoid, malonildialdehit (MDA), klorofil a, b ve toplam klorofil içeriği gibi parametreler incelenmiştir. Araştırma sonucunda; putresin dozlarının klorofil a ve toplam klorofil miktarları hariç incelenen diğer parametreler üzerindeki etkisi istatistiksel olarak önemli bulunmuştur. Çalışmada, en yüksek antioksidan aktivite miktarı (19.66 µmol TE/ gTA), toplam fenolik madde miktarı (108.0 mg GAE /gTA), toplam flavonoid madde miktarı (130.37 mg QE /100gTA), askorbik asit içeriği (22.58 mg LAA /100gTA) ve toplam karotenoid içeriği (5.35 μg/g TA) 50 mM putresin uygulamalarından, en yüksek MDA içeriği kontrol parsellerinden ve en yüksek klorofil b içeriği (13.76 μg/g TA) 100 mM putresin uygulamalarından tespit edilmiştir. En düşük değerler ise genel olarak kontrol parsellerinden belirlenmiştir. Putresin uygulamaları kontrole kıyasla incelenen parametreler üzerinde olumlu ve etkili olmuştur. Bitki üzerinde kullanılan dozların herhangi bir strese neden olmadığı, MDA miktarının, kontrole göre doz arttıkça azaldığı belirlenmiştir.
Adopting a socio-technical perspective to challenges and barriers of Blue-Green Infrastructure (BGI) transition
Authors: Sadegh Koohestani Somayeh , Mukheibir Pierre , Wakefield-Rann Rachael , Santamouris Mattheos
Published: February 2025

Blue-Green Infrastructure is widely recognized as one of the keys to addressing climate change impacts and rapid urbanization challenges. Integrating nature-based solutions enhances cities’ resiliency through sustainable stormwater management, mitigating flood risks while providing various ecosystem services. However, despite these multiple benefits and co-benefits, BGI remains far from mainstream adoption. We conducted a selective literature review to explore this practical gap guided by the socio-technical transition theory. We then employed a multi-level perspective to conceptualize the results, as it helps elucidate the complex nature of this problem beyond the standard variables considered in the existing literature on challenges and barriers to BGI uptake. Finally, we argued the necessity of societal and institutional considerations in addition to the technical aspects while investigating it systematically. We categorized the findings into five clusters including institutional and governance, economics and finance, knowledge and experience, socio-cultural challenges, and spatial planning practices. These clusters are highly interconnected and influenced by one another, revealing the complexity of this issue. Based on these findings, we suggest approaching BGI transitions as a complex problem by using systems thinking practices. This would necessitate dynamic interdisciplinary and connective collaborations among different organizations to bridge this gap.
A inclusão de alunos surdos em uma escola regular do município de Mossoró/RN com auxílio de jogos matemáticos adaptados em língua brasileira de sinais
Authors:   , Nogueira Silvana da Silva
Published: February 2025

Pensar a educação e inclusão para todos tem sido um desafio para as pessoas que trabalham na área da educação em nível mundial, tais pesquisadores se unem em busca de alcançar resultados satisfatórios. A dissertação aqui apresentada, se associa às pesquisas que buscam contribuir e construir possibilidades de inclusão de surdos na escola regular com auxílio de um jogo Matemático adaptado em Língua Brasileira de Sinais. Tendo como objetivo, compreender se e como os jogos matemáticos adaptados podem contribuir na inclusão de alunos surdos em uma escola da rede pública de Mossoró/RN, na qual os professores da disciplina de Matemática do oitavo e nono ano, não se comunicam em Língua Brasileira de Sinais-LIBRAS. Concretizamos uma pesquisa qualitativa com metodologia de pesquisa-intervenção que contou com a colaboração de alunos surdos, ouvintes e professores de Matemática da referida instituição. A investigação teve início a partir da busca e estudos com base em autores antecessores do tema e posteriormente desenvolvemos procedimentos metodológicos iniciados com observações, entrevistas, confecção e aplicação de um jogo/dominó com o conteúdo matemático “produtos notáveis” e, por fim, a aplicação de um questionário com questionamentos voltados para a aceitação e avaliação do jogo. Ao final, os dados indicaram resultados efetivos ao processo de inclusão de surdos na escola regular mediada pelos jogos matemáticos adaptados em Língua Brasileira de Sinais. Acreditamos que os resultados da pesquisa podem contribuir para o ensino/aprendizagem de surdos na escola regular, auxiliar professores nas aulas de Matemática e colaborar com outras pesquisas que visem a inclusão de alunos surdos na escola regular
Covalent Inhibitors - An Overview of Design Process, Challenges and Future Directions
Authors: Mugisa Simon , Murahari Manikanta
Published: February 2025

Covalent inhibitor drugs or targeted covalent inhibitors (TCI) are a type of drug category that interact
with their target by covalent bond formation. They represent a unique category having desired properties
such as high potency and longer duration of action, making them an attractive opportunity to pursue by researchers
in drug discovery. In history, covalent inhibitors were often discovered serendipitously (e.g. aspirin
and penicillin). However, modern times have witnessed numerous cases of rational design of these drugs,
which has caused their rise to occupy a significant fraction of marketed drugs (over 30%). Here, we have given
an overview of the discovery process of covalent inhibitors, including target identification/validation, warhead
selection and optimization, linker design and conjugation and the role of computational tools in covalent inhibitors.
To conclude, the challenges facing in this field and future directions to foresee are discussed. The objective
of this article is to provide a summary of the general development process of covalent inhibitors as well
as prospects or research gaps awaiting to be solved to overcome the challenges that hinder the discovery of
covalent drugs.
Synthesis of Novel Substituted Bis(benzimidazole)amine, N-Benzimidazole (benzothiazole)amine, and N-Benzimidazole(benzoxazole)amine Under
Ultrasound Irradiation via Copper-Catalyzed Reaction
Authors: nematpour manijeh
Published: February 2025

In this work, novel bis(benzimidazole)amine, N-benzimidazole(benzothiazole)amine, and
N-benzimidazole(benzoxazole)amine have been synthesized via a one-pot, intramolecular cyclization
of 2-iodoaniline and 2-aminobenzimidazoles (thiazoles and oxazoles)-trichloroacetonitrile adduct
using copper(I) iodide and DMF under ultrasound-assisted reaction with moderate to good yields.
Using basic materials and simple and available reagents, gentle copper-catalyzed reaction conditions,
easy purification with the help of solvent, good yields, non-addition of ligands, application of a simple
and efficient sonochemical method, short reaction times, and the synthesis of 15 new heterocycle
compounds have been appreciable features of this protocol.
Prevalence and Adverse Outcomes of Iron Deficiency in Heart Failure
Authors: Habeeb Habeeb Abdulkareem , Todd Fraser , Valsalan Rohith , Schembri Emily , Noyhar John K. , Yip Gary , Anpalahan Mahesan
Published: February 2025

Introduction/Objective:

Outcomes of iron deficiency (ID) in heart failure (HF) with
preserved ejection fraction (HFpEF) or in samples with mixed heart failure subtypes are variably
described. Hence, we investigated the prevalence and adverse outcomes of ID in a sample of
mixed heart failure subtypes.

Methods:

Adult patients admitted with HF over a six-month period were retrospectively studied.
ID was defined as serum ferritin<100mcg/L, or serum ferritin 100-300mcg/L with serum transferrin
saturation<20%. For each case of ID, sex- and age-matched (within five years) controls
were selected. The primary outcome was the composite of all-cause mortality or readmissions up
to 12 months post-index admission.

Results:

Of the 245 patients admitted with HF [HFpEF: 83 (70.3%), HFrEF: 35 (29.6%)], 233
met the inclusion criteria. Iron studies were available for 131 patients and 59 (45%) had ID. ID
had a significant univariate association with the primary outcome (OR: 3.80, 95% CI: 1.42–
10.18, P=0.008), and it remained significant after controlling for age, anaemia, comorbidities,
and frailty (OR: 6.04, 95% CI: 1.18–30.85, P=0.031). ID also had a significant independent association
with readmissions (OR: 4.61, 95% CI: 1.15–18.43, P=0.03), but not with mortality
(OR: 1.17, 95% CI: 0.67-4.35, P=0.257). In post-hoc analysis, ID exhibited a significant association
with primary outcome in patients with HFrEF (OR: 14.12, 95% CI: 1.7-0-117.33,
P=0.014), but not in patients with HFpEF (OR: 1.8, 95% CI: 0.71-4.58, P=0.214).

Conclusion:

ID is common in patients hospitalised for heart failure and has been found to have a
significant association with the composite primary outcome, largely due to its effect on readmissions.
ID may have a differential effect on adverse outcomes with respect to heart failure subtypes.
Exploring Menstrual Disorders in Two Different Areas, Hamedan and Zahedan in Iran, after the Injection of the COVID-19 Vaccine
Authors: Parvareshi Hamrah Razieh , Mehri Fereshteh , Najafi Vosough Roya , Rahbari Amir Hosein , Hoseinbar Saeed
Published: February 2025

Background and Purpose:

After the injection of the COVID-19 vaccinations, many
women around the world have reported abnormalities in their menstrual periods. Hence, the objective
of our study was to compare the prevalence of menstrual abnormalities after the COVID-19
vaccine among females residing within two regions (Hamedan and Zahedan) that are different in
the length of sunlight in Iran.

Method:

The research (cross-sectional study) utilized a questionnaire to evaluate the menstrual status
following COVID-19 vaccination. Based on the determined sample size, 170 women were selected,
with 85 from Hamadan and 85 from Zahedan (both situated in Iran). Checklists were distributed
among women above the age of menarche in both regions who had been vaccinated, were not
pregnant or lactating, and did not have a history of primary ovarian insufficiency, hypothalamic
menopause, or hysterectomy. The demographic and clinical characteristics were assessed through
the questionnaire, which consisted of three parts: demographics, menstrual disorders after vaccination,
and length/repetition/quantity of menstruation disorders. Data analyzed using SPSS software at
descriptive and inferential levels included frequency, percentage, Chi-Square, and Fisher exact
tests, which were used for comparison.

Results:

A total of 170 females were included in our study; 85 females were from the Hamedan region,
and 85 females were from the Zahedan region. About 57.6% of participants reported menstrual
symptoms post-vaccination in the Hamedan region, and around 54.1% of women experienced
these disorders in the Zahedan region (P-value 0.643). The frequency of people in the study who
had disorders in length was higher in the Hamedan region (P-value 0.208). Also, disorders in the
intensity and recurrence of their menstruation were higher in the Hamedan region than in the
Zahedan region (P-value 0.054).

Conclusion:

This research has demonstrated a potential correlation between the intensity of menstrual
disorders experienced by women following the administration of the COVID-19 vaccine and
the duration of sun exposure, which impacts the level of vitamin D in the body. Hence, it is crucial
to comprehend and substantiate this association as it holds significant value for the well-being of
women and, subsequently, the health of future generations.
An Extensive Evaluation of Recent Developments in B. Orellana's Phytochemistry and Pharmacology
Authors: Akhtar Wasim , Sharma Himanchal , Ekbbal Rustam , Sharma Anuj Kumar
Published: February 2025

Bixa Orellana, known as annatto, has gained significant attention due to its diverse
phytochemical composition and wide range of pharmacological activities. This review provides a
comprehensive evaluation of the latest advancements in the phytochemistry and pharmacology of
B. Orellana. The plant is rich in a variety of bioactive compounds, including carotenoids, flavonoids,
and tocotrienols, which contribute to its therapeutic potential. Recent studies have highlighted
the antioxidative, antimicrobial, anti-inflammatory, and anticancer properties of these
compounds, supporting the traditional use of B. Orellana in various ethno-medicinal practices.
Furthermore, the underlying mechanisms of action of these bioactive constituents are discussed,
with an emphasis on their interaction with molecular targets that regulate oxidative stress, inflammation,
and cell proliferation. The pharmacokinetics, safety profile, and potential side effects
of B. Orellana extracts are also reviewed, underscoring the need for further research to establish
standardized dosages and formulations. Additionally, the application of advanced extraction techniques
and novel delivery systems to enhance the bioavailability and efficacy of B. Orellanaderived
compounds is explored. This review aims to consolidate the current knowledge on B.
Orellana, providing insights into its potential as a source of natural therapeutics and laying the
groundwork for future research and development in this field. By synthesizing the findings from
recent studies, this paper contributes to a deeper understanding of B. Orellana’s pharmacological
potential, ultimately supporting its integration into modern healthcare practices.
A Review on Nanotechnology based In Situ Gelling System as a Reliable Weapon for Targeting Alzheimer’s Disease via Intranasal Route
Authors: Deorankar Priyanka , Minglani Vahid Vikram , Prajapati Bhupendra G. , Patel Meenakshi B.
Published: February 2025

A recent World Health Organization report claims that along with the growing world
population and emerging life prospects, the prevalence of neurological disorders is also increasing.
Out of all neurological disorders, Alzheimer's disease is the most widespread and alarming concern.
The disease poses significant therapeutic challenges due to the blood-brain barrier's restrictiveness
and the lack of effective drug delivery systems. The olfactory and trigeminal nerves have direct access
to the brain, therefore, intranasal drug delivery can be a promising route for the direct delivery
of anti-Alzheimer’s drugs. Despite this advantage, brain targeting is limited through this route due
to mucociliary clearance. Thus, in situ, nanotechnology offers a transformative approach by leveraging
the intranasal route to directly target the central nervous system. This comprehensive review
discusses recent advancements, mechanisms, and applications of in situ nanotechnology in Alzheimer's
disease therapeutics, highlighting its potential to enhance drug delivery efficiency, improve
bioavailability, and mitigate the progression of this debilitating condition. The importance of intranasal
drug delivery has been emphasized in this review, along with the clear benefits of in situ lipid-
based nanotechnology for the efficient delivery of medication in targeting Alzheimer's disease.
An Approach to Analyze Chest X-ray Using Convolutional Neural Network for Effective Diagnosis of COVID-19
Authors: Dubey Anil Kumar , Kapoor Raman , Yadav Vikash
Published: February 2025

Introduction:

The novel coronavirus has significantly affected the lives of people. The
exponentially increasing number of COVID-19 patients has put immense pressure on healthcare
services across the globe. Before the pandemic phase, the number of medical professionals per individual
was poor across many countries. Subsequently, the pressure on the medical fraternity has been
very high.

Method:

In such a situation, a fast and reliable diagnosis is expected to greatly help medical professionals.
With this view, we present an analysis of X-ray images, which will allow quarantine of highrisk
patients before final reports are available. This is expected to restrain the transmission of the
pandemic to a great extent. X-ray diagnostic facilities are relatively cheaper and readily available
compared with the reverse transcription-polymerase chain reaction (RT-PCR) tests.

Result:

Hence initial diagnosis using X-ray results is expected to be highly effective in segregating
patients of COVID-19. A deep learning (DL) based convolutional neural network (CNN) model is
presented, which detects high-risk patients of COVID-19 with an accuracy as high as 97.5.

Conclusion:

This method is expected to significantly reduce the load on medical professionals as
high-risk individuals can be quarantined before they cause any transmission.
Green Synthesis of Chlorophyllin-Based Ag Nanoparticles to Target Escherichia coli and Staphylococcus aureus
Authors: Podder Sandipa , Saha Saikat , Chakrovorty Arnob , Bhattacharjee Banani , Hossen Molla Sabir , Tarafdar Debojyoti , Nandi Sisir , Samadder Asmita
Published: February 2025

Background:

Bacteria resist drugs by employing new resistance mechanisms, leading to
prolonged infection and complexity in therapeutic prognosis that concordantly decreases drug efficacy.
In recent years, nanotechnology has gained immense popularity for the development of drug
delivery systems to combat the global pharmaceutical crisis of multi-drug resistance.

Objective:

The present work aimed to focus on the green chemistry-based synthesis of silver nanoparticles
(AgNPs) using the phytocompound chlorophyllin to form chlorophyllin precipitated silver
nanoparticles (NCHL) and elucidate their application against two pathologically significant bacterial
species Escherichia coli and Staphylococcus aureus.

Methods:

After optimization of experimental parameters, the physico-chemical properties of the
synthesized NCHL were determined using AFM, DLS, XRD, UV-Vis, SPR, and FTIR, respectively.
The interaction of NCHL with ct-DNA was assessed using CD spectroscopy. The antimicrobial
activity of the synthesized NCHL against Escherichia coli and Staphylococcus aureus was examined
by a disc diffusion susceptibility test.

Results:

The NCHL was ascertained to be ~53.57 nm in size, having a spherical shape, smooth topology,
negative zeta potential of -23.94 mV, and PDI value of 0.495. A sharp peak for silver as
SPR and an XRD peak depicted the best fit metallic crystal synchronization. FTIR analysis revealed
the presence of a similar functional group in NCHL and chlorophyllin (CHL). CD spectroscopy
with ct-DNA in the presence of NCHL showed a change in spectral shift of the ct-DNA, indicating
strong ct-DNA-NCHL interaction. NCHL successfully inhibited the growth of both bacterial
strains, indicating broad spectrum activity of the synthesized nanoparticles.

Conclusion:

The promising results indicated that NCHL could be utilized as a potential therapeutic
molecule against Escherichia coli and Staphylococcus aureus infections and help in combating bacterial
drug resistance, which is of high medical priority.
Graphic organizer: Methodological strategy for meaningful student learning
Authors: Poma Solier Teodosio Zenobio
Published: February 2025

It is difficult to explain and describe the reality of a phenomenon, especially for teachers, who must make themselves understood through pedagogical mediation, the organization of information, and the transmission of knowledge using different tools and resources that associate ideas in the same way the human brain does. The study aims to determine the impact of graphic organizers as a methodological strategy on the meaningful learning of students in the Educational Management course. This is a quantitative study with a quasi-experimental design that uses observation and surveys as data collection techniques, as well as a checklist and the ACRA Scale on Learning Strategies as instruments. The results support the alternative hypothesis and reject the null hypothesis. Both the control group and the experimental group differ significantly in terms of measurement.
The internalization of Ngaben ceremony values in history learning to enhance students' cultural literacy and social attitudes.
Authors: Mudana I Wayan , Widiana I Wayan , Kurniawan Made Ferry
Published: February 2025

This study aims to analyze the impact of the internalization of Ngaben ceremony values in history learning on students' cultural literacy and social attitudes. A quantitative research approach was employed using a quasi-experimental research design. The research design used was the posttest-only control group design. The study was conducted in a Senior High School in Buleleng Regency, Bali Province, with a population of 547 students. The sample was selected using a random sampling technique, resulting in 61 students divided into two classes: an experimental group and a control group. A questionnaire method was used for data collection. Cultural literacy was measured using a cultural literacy questionnaire, while social attitudes were assessed using a social attitude questionnaire. The data were analyzed quantitatively using descriptive and inferential analysis methods. Hypothesis testing was conducted using the Multivariate Analysis of Variance (MANOVA) technique.The results showed that the F-values for Pillai’s Trace, Wilks’ Lambda, Hotelling’s Trace, and Roy’s Largest Root were 12.710, with a significance value of 0.000 (which is lower than the significance threshold of 0.05). This indicates a significant simultaneous difference in cultural literacy and social attitudes between students who received history learning that internalized Ngaben ceremony values and those who did not. Various components supporting the Ngaben ceremony demonstrate that it is closely related to cultural activities, thereby enhancing students' cultural literacy. The essence of the Ngaben ceremony lies in its educational values, which can be instilled in students to shape their social attitudes.
Identifying Research Priorities in Digital Education for Health Care: Umbrella Review and Modified Delphi Method Study
Authors: Potter Alison , Munsch Chris , Watson Elaine , Hopkins Emily , Kitromili Sofia , O'Neill Iain Cameron , Larbie Judy , Niittymaki Essi , Ramsay Catriona , Burke Joshua , Ralph Neil
Published: February 2025

Background

In recent years, the use of digital technology in the education of health care professionals has surged, partly driven by the COVID-19 pandemic. However, there is still a need for focused research to establish evidence of its effectiveness.

Objective

This study aimed to define the gaps in the evidence for the efficacy of digital education and to identify priority areas where future research has the potential to contribute to our understanding and use of digital education.

Methods

We used a 2-stage approach to identify research priorities. First, an umbrella review of the recent literature (published between 2020 and 2023) was performed to identify and build on existing work. Second, expert consensus on the priority research questions was obtained using a modified Delphi method.

Results

A total of 8857 potentially relevant papers were identified. Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology, we included 217 papers for full review. All papers were either systematic reviews or meta-analyses. A total of 151 research recommendations were extracted from the 217 papers. These were analyzed, recategorized, and consolidated to create a final list of 63 questions. From these, a modified Delphi process with 42 experts was used to produce the top-five rated research priorities: (1) How do we measure the learning transfer from digital education into the clinical setting? (2) How can we optimize the use of artificial intelligence, machine learning, and deep learning to facilitate education and training? (3) What are the methodological requirements for high-quality rigorous studies assessing the outcomes of digital health education? (4) How does the design of digital education interventions (eg, format and modality) in health professionals’ education and training curriculum affect learning outcomes? and (5) How should learning outcomes in the field of health professions’ digital education be defined and standardized?

Conclusions

This review provides a prioritized list of research gaps in digital education in health care, which will be of use to researchers, educators, education providers, and funding agencies. Additional proposals are discussed regarding the next steps needed to advance this agenda, aiming to promote meaningful and practical research on the use of digital technologies and drive excellence in health care education.
Identifying Research Priorities in Digital Education for Health Care: Umbrella Review and Modified Delphi Method Study (Preprint)
Authors: Potter Alison , Munsch Chris , Watson Elaine , Hopkins Emily , Kitromili Sofia , O'Neill Iain Cameron , Larbie Judy , Niittymaki Essi , Ramsay Catriona , Burke Joshua , Ralph Neil
Published: February 2025

BACKGROUND

In recent years, the use of digital technology in the education of health care professionals has surged, partly driven by the COVID-19 pandemic. However, there is still a need for focused research to establish evidence of its effectiveness.

OBJECTIVE

This study aimed to define the gaps in the evidence for the efficacy of digital education and to identify priority areas where future research has the potential to contribute to our understanding and use of digital education.

METHODS

We used a 2-stage approach to identify research priorities. First, an umbrella review of the recent literature (published between 2020 and 2023) was performed to identify and build on existing work. Second, expert consensus on the priority research questions was obtained using a modified Delphi method.

RESULTS

A total of 8857 potentially relevant papers were identified. Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology, we included 217 papers for full review. All papers were either systematic reviews or meta-analyses. A total of 151 research recommendations were extracted from the 217 papers. These were analyzed, recategorized, and consolidated to create a final list of 63 questions. From these, a modified Delphi process with 42 experts was used to produce the top-five rated research priorities: (1) How do we measure the learning transfer from digital education into the clinical setting? (2) How can we optimize the use of artificial intelligence, machine learning, and deep learning to facilitate education and training? (3) What are the methodological requirements for high-quality rigorous studies assessing the outcomes of digital health education? (4) How does the design of digital education interventions (eg, format and modality) in health professionals’ education and training curriculum affect learning outcomes? and (5) How should learning outcomes in the field of health professions’ digital education be defined and standardized?

CONCLUSIONS

This review provides a prioritized list of research gaps in digital education in health care, which will be of use to researchers, educators, education providers, and funding agencies. Additional proposals are discussed regarding the next steps needed to advance this agenda, aiming to promote meaningful and practical research on the use of digital technologies and drive excellence in health care education.
Development of a Web-based Intervention to Support Primary Healthcare Professionals in eHealth Measurement: A User-centered Participatory Approach (Preprint)
Authors: Meijers Kristel , Bols Esther , Beekman Emmylou , Slangen Rachel , van de Hoef Peter Alexander , Ummels Darcy , Crutzen Rik
Published: February 2025

BACKGROUND

eHealth measurement offers opportunities to address several primary healthcare challenges, but healthcare professionals encounter significant implementation barriers. Therefore, resources need to be developed to facilitate integration of eHealth measurement tools into daily practice.

OBJECTIVE

This study aimed to identify the most appropriate format and content for an intervention to support primary healthcare professionals in adopting eHealth measurement tools. Furthermore, we describe and reflect on the development process.

METHODS

Using a participatory action research approach and user-centered design principles, 19 primary healthcare professionals from four disciplines - physical therapy, occupational therapy, speech and language therapy, and general practitioner practice assistancy - participated in intervention development as end-users. External experts were consulted to broaden perspectives. Data were collected within three iterative stages (concept, design, testing and trials) between January 2022 and December 2023, during co-creative meetings, individual interviews, focus group discussions, usability testing and prototype use in daily practice. Content analysis and descriptive statistics were used to analyze the data.

RESULTS

A web-based, stepwise intervention combining theoretical information, practical aids, examples, and experiences, proved most suitable. Key features were concise content, intuitive graphic design, and flexible navigation and functionalities. Iterative improvements led to an increase in usability ratings, from “OK” to “good to excellent”.

CONCLUSIONS

Different healthcare disciplines benefit from similar support strategies, yet this requires careful balancing of intervention design and content. Combining participatory action research and user-centered design principles was useful to tailor the intervention to end-users’ daily routines. The described development process offers a replicable framework for creating support strategies for eHealth measurement in various healthcare settings.
DUE CENSORSHIP
Authors: Manuel Rosales Dr. Carlos
Published: February 2025

La libertad de expresión es la principal fuente de intercambio de ideas en el debate público dentro de una democracia liberal. La censura ha operado y servido como un instrumento de límite a la libertad de expresión debido a que se considera que ésta causa o puede causar daños. Pero, hay ocasiones en las que la censura es necesaria para salvaguardar el orden público, la seguridad del Estado o los intereses públicos. Este artículo presenta argumentos a favor de la censura y algunos casos en los que la debida censura ha sido validada como un instrumento de control a la información pública.
HACIA UNA ACCIÓN PREVENTIVA DEL DAÑO EN MÉXICO
Authors: Jiménez Trejo Lic. Diego
Published: February 2025

Este trabajo analiza la función preventiva de la responsabilidad civil, enfocándose en la posibilidad de evitar daños antes de que estos ocurran, mediante la implementación de la tutela civil inhibitoria en México. La propuesta busca solventar una laguna normativa nacional, permitiendo la prevención de daños previsibles a través de una acción genérica civil.
EL PROCESO DE INTEGRACIÓN ANDINO. LA COMUNIDAD ANDINA Y SU ESTRUCTURA JURÍDICA
Authors: Núñez Rocha Dr. Hernán
Published: February 2025

Este artículo aborda el proceso de integración andino, a la luz de los principales acontecimientos internacionales y la adopción de tratados y actos jurídicos de naturaleza comunitaria. Se respasan los antecedentes que subyacen en la conformación y el funcionamiento de la Comunidad Andina y se analiza su desarrollo normativo e institucional, con el fin de entender sus particularidades, certezas y desorientaciones. Se comenta de forma crítica los hechos que han debilitado a la organización, así como las actuaciones de sus órganos e instituciones que han comprometido la estabilidad y seguridad jurídica. Finalmente, se destacan los aspectos sólidos de la integración andina y qué pueden aportar a la construcción de instancias supranacionales eficientes, que cumplan con las expectativas y necesidades de los países miembros.
Efektifitas Penegakan Hukum Oleh Satuan Polisi Pamong Praja Dan Wilayatul Hisbah Terhadap Penanganan Kasus Pelecehan Seksual Yang Diungkapkan Melalui Media Massa Di Kota Banda Aceh
Authors: Ti Safur  , Mahdalena
Published: February 2025

Kajian ini untuk menjawab permasalahan Efektifitas Penegakan Hukum Oleh Satpol PP & WH dalam menangani kasus pelecehan seksual yang viral melalui media massa di Kota Banda Aceh, Kasus pelecehan seksual merupakan kejahatan terhadap keasusilaan yang menyerang fiisik korban secara langsung maupun tidak langsung, pelecehan seksual ini adalah perbuatan yang mengarah pada area seksualitasnya seseorang untuk memenuhi hawa nafsu sipelaku terhadap korban. Dalam kasus pelecehan seksual yang ingin dibahas oleh penulis yaitu ditemukan tiga orang remaja yang melakukan pelecehan seksual melalui live straming melalui  aplikasi tiktok di salah satu parkiran mobil yang ada di warung kopi Peunayong hingga kasus tersebut viral dimedia sosial dan media massa.  Berdasarkan keterangan dari KABID (kepala bidang) penegakan syariat islam Wilayatul Hisbah Kota Banda Aceh setelah dilakukannya pemeriksaan  lebih lanjut para pelaku tersebut dinyatakan memenuhi unsur dan diberikan peringatan atau pembinaan. kasus pelecehan seksual yang viral tersebut ditangani dengan mudah serta efektif, apabila dibandingkan dengan beberapa kasus pelanggaran syariat islam lainnya  yang tidak viral. Rumusan masalahnya ialah pertama. Bagaimana efektifitas penegakan hukum oleh Satpol PP dan WH Kota Banda Aceh terhadap penanganan kasus pelecehan seksual yang viral dimedia sosial dan media massa di Kota Banda Aceh.. Kedua, Bagaimana upaya yang dapat diberikan oleh Pemerintah Aceh kepada lembaga penegakan hukum untuk meminimalisir kendala-kendala dalam pemeriksaan. Penelitian ini dilakukan menggunakan pendekatan kualitatif menggunakan jenis penelitian empiris. Dari hasil penelitian didapatkan kesimpulan bahwa aparat penegak hukum Satpol PP dan WH Kota Banda Aceh menyatakan bahwa efektif dalam menangani kasus Pelecehan Seksual yang viral dan diungkapkan melalui media massa tersebut. Efektifnya penegakan hukum selama pemerikasaan berlangusng itu disebabkan oleh faktor dukungan dari netizen yang ikut melaporkan hal tersebut dengan cepat serta memudahkan penyidik dalam melakukan pemeriksaan akibat kasus yang mereka lakukan viral, Jika dibandingkan dengan kasus yang tidak viral aparat mengaku susah dalam menanganinya hingga penanganan yang diberikan terbilang kurang efektif. Hal itu disebabkan oleh beberapa faktor adapun faktornya adalah kurangnya sarana dan prasarana yang diberikan oleh pemerintah Aceh kepada lembaga penegakan hukum.
Herramientas digitales para la optimización del aprendizaje significativo de Ciencias Naturales en un grupo multigrado
Authors:   investigador independependiente, Armas Castillo Lorena Karina
Published: February 2025

La investigación titulada Herramientas digitales para la optimización del aprendizaje significativo de Ciencias Naturales en un grupo multigrado de básica media se fundamenta en la necesidad de integrar tecnologías digitales como respuesta a los desafíos educativos en contextos multigrado, favoreciendo la construcción de aprendizajes significativos. El objetivo principal fue diseñar e implementar estrategias basadas en herramientas digitales que optimicen el proceso de enseñanza-aprendizaje en Ciencias Naturales, atendiendo a las características heterogéneas de los estudiantes. Se utilizó una metodología mixta con diseño descriptivo, empleando técnicas como encuestas dirigidas a estudiantes y docentes, entrevistas al director escolar y observación directa de clases. Los datos recopilados permitieron identificar las prácticas pedagógicas habituales, el nivel de apropiación tecnológica y las principales dificultades en el uso de recursos digitales. Entre los resultados más relevantes, se evidenció que el uso de herramientas digitales promueve la participación activa, facilita la comprensión de conceptos abstractos y mejora el desempeño académico en Ciencias Naturales. Asimismo, se destacó la importancia de la capacitación docente continua para garantizar el aprovechamiento óptimo de estos recursos. Como conclusión, se diseñó una guía metodológica para docentes y estudiantes, validada por expertos, que demostró ser una herramienta efectiva para fortalecer el aprendizaje significativo en contextos educativos multigrado.
Discrimination and Workplace Harassment (Mobbing) against Women in the Post-Pandemic Era
Authors: Fuentes-Valdivieso Rocío
Published: February 2025

The objective of this paper is to study work environments and the set of contradictions that make up mobbing or group
harassment in the post-pandemic. Mobbing or group harassment is one of the problems that afflicts different organizations and
institutions; it is a multi-causal phenomenon that occurs in different ways almost everywhere in the world. Mobbing is related
to violence at work, it is characterized by the development of hostile behaviors, some open, others veiled. Discrimination is
one of its main components. The methodology applied in this study was the qualitative methodology. The findings show that
in mobbing, the socio-subjectivities imposed in a work environment prevail. The labor relations that emerged from the postpandemic are part of said socio-subjectivity. This not only means the subjective formation of the individual, but also the social
context in which human beings develop