bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical determination of the substrate’s zero-chirp geometry for the elimination of the period chirp in laser interference lithography
Authors: Bienert Florian , Röcker Christoph , Graf Thomas , Abdou Ahmed Marwan
Published: August 2024

The technique of deliberately bending the substrate during the exposure offers a promising solution to eliminate the period chirp in laser interference lithography. The exact geometry of the substrate to allow for this elimination is given by the solution of an ordinary differential equation (ODE) which has not been solved before. We therefore present a new contemplation of this particular ODE and its solution, the zero-chirp geometry. Considering the planes of constructive interference, we investigated the solution space of the ODE and from this, a more general form of the ODE is developed. Finally, the approach to solve the ODE is described for a specific example, enabling for the first time the determination of the zero-chirp geometry of the substrate to fully eliminate the period chirp in laser interference lithography.
Ein Werkzeug zur Analyse von Komplexität von Low-Code und No-Code Add-ons: Ein Design Science Ansatz
Authors: Abendroth Adrian , Bender Benedict
Published: August 2024

In der schnelllebigen Geschäftswelt von heute ist es für Unternehmen entscheidend, sich rasch an veränderte Marktbedingungen anzupassen, um ihre Wettbewerbsfähigkeit zu sichern. Flexibilität und maßgeschneiderte Prozesse sind dabei zentrale Erfolgsfaktoren, die oft über die Möglichkeiten standardisierter Anwendungssysteme hinausgehen. Low-Code-Plattformen (LCP) wie Mendix und Outsystems sowie No-Code-Plattformen (NCP) wie Bubble bieten vielversprechende Ansätze zur Realisierung individueller Anpassungen durch visuelle und deklarative Techniken, die herkömmliche Programmierung ersetzen.

Vor der Adoption einer solchen Plattform müssen Unternehmen beurteilen, wie gut eine spezifische LCP/NCP ihre individuellen Anforderungen erfüllen kann. Der mögliche Anforderungserfüllungsgrad hängt nicht nur von den Grundfunktionen einer Platform ab, sondern insbesondere von den verfügbaren Erweiterungen im Plattform-Ökosystem. Add-on-Stores bieten Zugang zu spezialisierten Erweiterungen, die die Grundfunktionen der Plattformen ergänzen und an spezifische Unternehmens-bedürfnisse anpassen können.

Um die Eignung einer LCP/NCP für spezielle Anwendungsfälle zu bewerten, entwickelt dieser Beitrag ein Messinstrument zur Erfassung der Komplexität von Add-on-Stores unter Anwendung der Design Science Research Methode (DSR). Die Bewertung basiert auf der Analyse von 1483 Add-ons aus den Add-on-Stores von Microsoft Power Apps, Outsystems und Pega. Dieses Instrument ermöglicht es Unternehmen, die Vielfalt und Tiefe der verfügbaren Add-ons zu erfassen und somit fundierte Entscheidungen darüber zu treffen, ob eine LCP/NCP adoptiert werden soll. Dieser Beitrag unterstützt somit die Optimierung der Entscheidungsfindung bei der Auswahl von LCP/NCP.
Differential Expression of Branched-Chain Aminotransferase in the Rat Ocular Tissues
Authors: Aldosari Dalia I. , Alshawakir Yasser A. , Alanazi Ibrahim O. , Alhomida Abdullah S. , Ola Mohammad S.
Published: August 2024

Branched-chain amino acids (BCAAs) play vital roles in metabolic and physiological processes, with their catabolism initiated by two branched-chain aminotransferase isozymes: cytosolic (BCATc) and mitochondrial (BCATm). These enzymes have tissue and cell-specific compartmentalization and are believed to shuttle metabolites between cells and tissues. Although their expression and localization have been established in most tissues, ocular tissues remain unknown. In this study, we used immunohistochemical analyses to investigate the expression and localization of BCAT enzymes in the normal eye tissues. As expected, BCATc was highly expressed in the neuronal cells of the retina, particularly in the ganglion cell layers, inner nuclear layer, and plexiform layer, with little to no expression in Müller cells. BCATc was also present in the cornea, retinal pigment epithelium (RPE), choroid, ciliary body, and iris but not in the lens. In contrast, BCATm was expressed across all ocular tissues, with strong expression in the Muller cells of the retina, the endothelial and epithelial layers of the cornea, the choroid and iris, and the epithelial cells at the lens’s front. The extensive expression and distribution of BCAT isozymes in the ocular tissue, suggests that BCAA transamination is widespread in the eye, potentially aiding in metabolite transport between ocular tissues. The findings provide new insights into the physiological role of BCATs in the eye, particularly within the neuronal retina.
Novel mathematical approach to accurately quantify 3D endothelial cell morphology and vessel geometry based on fluorescently marked endothelial cell contours: Application to the dorsal aorta of wild-type and Endoglin-deficient zebrafish embryos
Authors: Seeler Daniel , Grdseloff Nastasja , Rödel Claudia Jasmin , Kloft Charlotte , Abdelilah-Seyfried Salim , Huisinga Wilhelm
Published: August 2024

Endothelial cells, which line the lumen of blood vessels, locally sense and respond to blood flow. In response to altered blood flow dynamics during early embryonic development, these cells undergo shape changes that directly affect vessel geometry: In the dorsal aorta of zebrafish embryos, elongation of endothelial cells in the direction of flow between 48 and 72 hours post fertilization (hpf) reduces the vessel’s diameter. This remodeling process requires Endoglin; excessive endothelial cell growth in the protein’s absence results in vessel diameter increases. To understand how these changes in vessel geometry emerge from morphological changes of individual endothelial cells, we developed a novel mathematical approach that allows 3D reconstruction and quantification of both dorsal aorta geometry and endothelial cell surface morphology. Based on fluorescently marked endothelial cell contours, we inferred cross-sections of the dorsal aorta that accounted for dorsal flattening of the vessel. By projection of endothelial cell contours onto the estimated cross-sections and subsequent triangulation, we finally reconstructed 3D surfaces of the individual cells. By simultaneously reconstructing vessel cross-sections and cell surfaces, we found in an exploratory analysis that morphology varied between endothelial cells located in different sectors of the dorsal aorta in both wild-type and Endoglin-deficient zebrafish embryos: In wild-types, ventral endothelial cells were smaller and more elongated in flow direction than dorsal endothelial cells at both 48 hpf and 72 hpf. Although dorsal and ventral endothelial cells in Endoglin-deficient embryos had similar sizes at 48 hpf, dorsal endothelial cells were much larger at 72 hpf. In Endoglin-deficient embryos, elongation in flow direction increased between 48 hpf and 72 hpf in ventral endothelial cells but hardly changed in dorsal endothelial cells. Hereby, we provide evidence that dorsal endothelial cells contribute most to the disparate changes in dorsal aorta diameter in wild-type and Endoglin-deficient embryos between 48 hpf and 72 hpf.
Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome
Authors: Elkrewi Marwan , Vicoso Beatriz
Published: August 2024

Our understanding of the molecular pathways that regulate oogenesis and define cellular identity in the Arthropod female reproductive system and the extent of their conservation is currently very limited. This is due to the focus on model systems, including Drosophila and Daphnia, which do not reflect the observed diversity of morphologies, reproductive modes, and sex chromosome systems. We use single-nucleus RNA and ATAC sequencing to produce a comprehensive single nucleus atlas of the adult Artemia franciscana female reproductive system. We map our data to the Fly Cell Atlas single-nucleus dataset of the Drosophila melanogaster ovary, shedding light on the conserved regulatory programs between the two distantly related Arthropod species. We identify the major cell types known to be present in the Artemia ovary, including germ cells, follicle cells, and ovarian muscle cells. Additionally, we use the germ cells to explore gene regulation and expression of the Z chromosome during meiosis, highlighting its unique regulatory dynamics and allowing us to explore the presence of meiotic sex chromosome silencing in this group.
Characterization of a unique catechol-O-methyltransferase as a molecular drug target in parasitic filarial nematodes
Authors: Mia Md Mukthar , Allaie Idrees Mehraj , Zhang Xuejin , Li Kun , Khan Shahbaz M. , Kadotani Saki , Witola William H.
Published: August 2024

Background

Filarial nematodes cause severe illnesses in humans and canines including limb deformities and disfigurement, heart failure, blindness, and death, among others. There are no vaccines, and current drugs against filarial nematodes infections have only modest effects and are prone to complications.

Methodology/principal findings

We identified a gene (herein called DiMT) encoding an S-adenosyl-L-methionine (SAM)-dependent methyltransferase with orthologs in parasite filarial worms but not in mammals. By in silico analysis, DiMT possesses catalytic sites for binding SAM and catecholamines with high affinity. We expressed and purified recombinant DiMT protein and used it as an enzyme in a series of SAM-dependent methylation assays. DiMT acted specifically as a catechol-O-methyltransferase (COMT), catalyzing catabolic methylation of dopamine, and depicted Michaelis Menten kinetics on substrate and co-substrate. Among a set of SAM-dependent methyltransferase inhibitors, we identified compounds that bound with high affinity to DiMT’s catalytic sites and inhibited its enzymatic activity. By testing the efficacy of DiMT inhibitors against microfilariae of Dirofilaria immitis in culture, we identified three inhibitors with concentration- and time-dependent effect of killing D. immitis microfilariae. Importantly, RNAi silencing of a DiMT ortholog in Caenorhabditis elegans has been shown to be lethal, likely as a result of excessive accumulation of active catecholamines that inhibit worm locomotion, pharyngeal pumping and fecundity.

Conclusions/significance

Together, we have unveiled DiMT as an essential COMT that is conserved in parasitic filarial nematodes, but is significantly different from mammalian COMTs and, therefore, is a viable target for development of novel drugs against filarial nematode infections.
Identification of echinoderm metabolites as potential inhibitors targeting wild-type and mutant forms of Escherichia coli RNA polymerase (RpoB) for tuberculosis treatment
Authors: Alsulais Fatimah M. , Alhaidhal Bayan A. , Mothana Ramzi A. , Alanzi Abdullah R.
Published: August 2024

Tuberculosis (TB) remains a critical global health challenge, with the emergence of drug-resistant strains heightening concerns. The development of effective drugs targeting both wild-type (WT) and mutant Escherichia coli RNA polymerase β subunit (RpoB) is crucial for global TB control, aiming to alleviate TB incidence, mortality, and transmission. This study employs molecular docking and ADMET analyses to screen echinoderm metabolites for their potential inhibition of Escherichia coli RNA polymerase, focusing on wild-type and mutant RpoB variants associated with TB drug resistance. The evaluation of docking results using the glide gscore led to the selection of the top 10 compounds for each protein receptor. Notably, CMNPD2176 demonstrated the highest binding affinity against wild-type RpoB, CMNPD13873 against RpoB D516V mutant, CMNPD2177 against RpoB H526Y mutant, and CMNPD11620 against RpoB S531L mutant. ADMET screening confirmed the therapeutic potential of these selected compounds. Additionally, MM-GBSA binding free energy calculations and molecular dynamics simulations provided further support for the docking investigations. While the results suggest these compounds could be viable for tuberculosis treatment, it is crucial to note that further in-vitro research is essential for the transition from prospective inhibitors to clinical drugs.
Prognostic value of systemic inflammatory response index for acute kidney injury and the prognosis of pediatric patients in critical care units
Authors: Lu Danchi , Tu Lijuan , Hu Yugang , Cai Xiaofang
Published: August 2024

Background

We proposed a link between the first systemic inflammatory response index (SIRI) and acute kidney injury (AKI), as well as the prognosis of pediatric patients in intensive care units (PICU).

Methods

This study comprised 5114 children from the pediatric-specific intensive care (PIC) database. SIRI was estimated as a neutrophil monocyte lymphocyte ratio. All patients were arbitrarily allocated to the training set (n = 3593) and the validation cohort (n = 1521) and divided into two groups depending on their SIRI levels. The diagnostic value of SIRI for pediatric ICU patients was subsequently determined using LASSO regression models.

Results

After controlling for additional confounding variables in the training set, the higher SIRI value (≥ 0.59) had a greater risk of AKI (adjusted odds ratio, OR, 3.95, 95% confidence interval, 95%CI, 2.91–5.36, P<0.001) and in-hospital mortality (hazard ratio, HR, 5.01, 95%CI 2.09–12.03, P<0.001). Similar findings were discovered in the validation set. Furthermore, the suggested nomogram derived from SIRI and other clinical metrics showed outstanding calibration capability as well as therapeutic usefulness in both groups.

Conclusions

SIRI is a reliable and useful factor for AKI and fatality in pediatric ICU patients, and the proposed nomogram based on SIRI yields an appropriate prediction value for critically sick pediatric patients.
Layout optimization of irregular storage areas under class storage strategy based on clustering and multi-bin size packing problem
Authors: Zhang Wenbin , Jin Yuehua , Zhang Ronghua , Wang Yiming
Published: August 2024

This paper proposes an optimization scheme for the layout of irregular warehouse spaces based on a class-based storage strategy. Firstly, we transform the irregular warehouse space into several regular rectangular areas. Next, through the class-based storage strategy, we develop an algorithm that converts the non-linear clustering problem of homogeneous shelves into a linear selection problem of different sized regular shelf areas. Finally, a comprehensive shelving clustering algorithm and packing problem with different box sizes selection were constructed, and empirical analysis was conducted based on actual data from Xiangtai Warehouse of State Grid Corporation of China. The results show that the new model not only effectively solves the irregular warehouse layout optimization problem under the class storage strategy but also reduces the complexity of the model and shortens the solution time. It is a universally applicable method with significant value for generalization.
Assessment of the antileishmanial activity of diallyl sulfide combined with meglumine antimoniate on Leishmania major: Molecular docking, in vitro, and animal model
Authors: Zarrinkar Farzaneh , Sharifi Iraj , Salarkia Ehsan , Keyhani Alireza , Babaei Zahra , Khamesipour Ali , Hakimi Parizi Maryam , Molaakbari Elaheh , Sharifi Fatemeh , Dabiri Shahriar , Bamorovat Mehdi
Published: August 2024

Currently, no safe vaccine against leishmaniasis is available. So far, different control strategies against numerous reservoir hosts and biological vectors have not been environment-friendly and feasible. Hence, employing medicinal components and conventional drugs could be a promising approach to developing novel therapeutic alternatives. This study aimed to explore diallyl sulfide (DAS), a dynamic constituent of garlic, alone and in a mixture with meglumine antimoniate (MAT as standard drug) using in vitro and animal model experiments against Leishmania major stages. The binding affinity of DAS and four major defense elements of the immune system (iNOS, IFN-ɣ, IL-12, and TNF-α) was used to predict the predominant binding mode for molecular docking configurations. Herein, we conducted a broad range of experiments to monitor and assess DAS and MAT potential treatment outcomes. DAS, combined with MAT, displayed no cytotoxicity and employed a powerful anti-leishmanial activity, notably against the clinical stage. The function mechanism involved immunomodulation through the induction of Th1 cytokine phenotypes, triggering a high apoptotic profile, reactive oxygen species (ROS) production, and antioxidant enzymes. This combination significantly decreased cutaneous lesion diameter and parasite load in BALB/c mice. The histopathological findings performed the infiltration of inflammatory cells associated with T-lymphocytes, particularly CD4+ phenotypes, as determined by biochemical markers in alleviating the amastigote stage and improving the pathological changes in L. major infected BALB/c mice. Therefore, DAS and MAT deserve further advanced therapeutic development and should be considered as possible candidates for treating volunteer cases with cutaneous leishmaniasis in designing an upcoming clinical trial.
The Indonesian consumer perspective on the massage industry: A conjoint analysis approach
Authors: Prasetyo Yogi Tri , Cahigas Maela Madel L. , Tan Abel Phillip , Kurniawan Lilian Evangelista , Prawiro Stevano Nyoto , Nadlifatin Reny , Gumasing Ma. Janice J. , Ayuwati Irene Dyah
Published: August 2024

The massage industry has been in the market for more than thousands of years. Consumers purchase massage services to treat illnesses, alleviate pain, or improve well-being. Despite the popularity of this industry and the benefits it entails, consumers’ preferences vary and massage parlors’ stakeholders have inconsistent market segmentation. Therefore, the purpose of this study was to investigate consumer preferences toward massage services offered by massage parlors in Indonesia through conjoint analysis. Conjoint analysis’ orthogonal design concentrated on stimuli preferences and it was further supported by generating 1.000 consistency and reliability based on Kendall Tau’s holdout. A total of 212 respondents answered the online questionnaire voluntarily. The results showed that the Google rating was the most important attribute (68.5%), followed by the gender of the massage therapist (12.4%), the type of massage (9.6%), the type of room (4.5%), the duration (3.6%) and the price (1.4%). Moreover, this research assessed 27 stimuli and found that the best combination was employing female massage therapists, IDR 100k-150k price every session, 90 minutes massage duration, couple room with two beds, acupuncture and cupping massage type, and massage parlors with greater than 4.6 Google review rating. This present research was one of the first studies that explored unique and holistic massage services through conjoint analysis. Unlike the previous studies that only focused on one massage service attribute or did not provide specific levels for evaluated attributes, the conjoint’s orthogonal design delivered a new perception of prioritizing both consumers and the business side as some would only focus on one or the other. Also, the findings could be useful for massage parlors’ stakeholders in developing marketing strategies, enhancing operational strategies, and promoting customer satisfaction. Marketing tactics such as promotional discounts would inspire customers to provide an optimistic Google review. Business owners were encouraged to focus on giving the best experience starting with a well-trained massage therapist, clean and hygienic rooms, and quality materials. These theoretical and practical implications aid in building the massage parlor’s credibility that could be perceived positively by consumers.
Development of a standardized consensus lexicon for terms related to micronutrient programs
Authors: Hlaing Lwin Mar , Bourassa Megan W. , Brown Kenneth H. , Atkin Reed , Osendarp Saskia J. M. , Gupta Aishani , Hess Sonja Y.
Published: August 2024

Inconsistent use of terminology among diverse stakeholders hinders effective communication in micronutrient programs, especially large-scale food fortification (LSFF) which involves stakeholders from different sectors. To align the terminology use, the Micronutrient Data Innovation Alliance (DInA) of the Micronutrient Forum (MNF) created a lexicon of terms related to LSFF and other micronutrient programs. The purpose of this lexicon is to establish a central repository of consensus definitions of key terms to facilitate communication among diverse stakeholders involved in micronutrient programs including public and private sectors, donor agencies, food industries, academic institutions, etc. This paper describes the methodology of lexicon development. Important terms related to micronutrient programs were compiled from multiple sources, including United Nations agencies, program implementation and technical support agencies, relevant websites, and scientific literature. The selection of terms was guided by key micronutrient interventions (fortification, supplementation, dietary diversification) and the program cycle (assessment, planning, implementation, monitoring and evaluation). Definitions of terms were identified from these references and checked for consistency across different sources. For terms with multiple definitions, a modified Delphi method was applied to harmonize the definitions. The first draft lexicon (n = 113 terms) was reviewed by six experts from the University of California, Davis (UCD) and MNF, and second draft (n = 115 terms) was shared with 24 global micronutrient experts for feedback. Fifty-four terms were found to have multiple definitions. Of which, minor modification was made for 12-terms with nominal difference and remaining 42-terms were shared with over 140 micronutrient-experts disseminated via an online survey through newsletters and emails to solicit experts’ opinions on the most appropriate definition or a modified one. Nineteen legal terms and 83 micronutrient terms (n = 102 terms) were subsequently added. Overall, 39 experts from diverse areas of expertise (LSFF, micronutrient program planning and implementation, surveys and research, policy development, food industry regulations, food safety, and public health nutrition) participated in the online survey. The terms with >75% agreement among experts were considered as final, while the remaining were reviewed again by experts from UCD and MNF until consensus was reached on harmonized definitions. The current lexicon is available online at the DInA-website. and contains 217 terms and will be maintained as a “living document”. The lexicon will facilitate the ability of key stakeholders of micronutrient programs to evaluate and compare program performance in order to make informed decisions on how to ensure future progress in reducing micronutrient deficiencies.
Methodological rigor and quality of reporting of clinical trials published with physical activity interventions: A report from the Strengthening the Evidence in Exercise Sciences Initiative (SEES Initiative)
Authors: Conrado Ignacio Andresa , Oliveira Nórton Luís , Xavier Neves da Silva Larissa , Feter Jayne , De Nardi Angélica Trevisan , Helal Lucas , Rodrigues dos Santos Marcelo , Soares Douglas dos Santos , Morgana Galliano Leony , Alano Tainá Silveira , Umpierre Daniel
Published: August 2024

Background

This study addresses the need for improved transparency and reproducibility in randomized clinical trials (RCTs) within the field of physical activity (PA) interventions. Despite efforts to promote these practices, there is limited evidence on the adherence to established reporting and methodological standards in published RCTs. The research, part of the Strengthening the Evidence in Exercise Sciences Initiative (SEES Initiative) in 2020, assessed the methodological standards and reporting quality of RCTs focusing on PA interventions.

Methods

RCTs of PA advice or exercise interventions published in 2020 were selected. Monthly searches were conducted on PubMed/MEDLINE targeting six top-tier exercise science journals. Assessments were conducted by two independent authors, based on 44 items originally from CONSORT and TIDieR reporting guidelines. These items were divided into seven domains: transparency, completeness, participants, intervention, rigor methodology, outcomes and critical analysis. Descriptive analysis was performed using absolute and relative frequencies, and exploratory analysis was done by comparing proportions using the χ2 test (α = 0.05).

Results

Out of 1,766 RCTs evaluated for eligibility, 53 were included. The median adherence to recommended items across the studies was 30 (18–44) items in individual assessments. Notably, items demonstrating full adherence were related to intervention description, justification, outcome measurement, effect sizes, and statistical analysis. Conversely, the least reported item pertained to mentioning unplanned modifications during trials, appearing in only 11.3% of studies. Among the 53 RCTs, 67.9% reported having a registration, and these registered studies showed higher adherence to assessed items compared to non-registered ones.

Conclusions

In summary, while critical analysis aspects were more comprehensively described, aspects associated with transparency, such as protocol registrations/modifications and intervention descriptions, were reported suboptimally. The findings underscore the importance of promoting resources related to reporting quality and transparent research practices for investigators and editors in the exercise sciences discipline.
Re-routing MAP kinase signaling for penetration peg formation in predator yeasts
Authors: Rij Mareike , Kayacan Yeseren , Bernardi Beatrice , Wendland Jürgen
Published: August 2024

Saccharomycopsis yeasts are natural organic sulfur auxotrophs due to lack of genes required for the uptake and assimilation of sulfate/sulfite. Starvation for methionine induces a shift to a predatory, mycoparasitic life strategy that is unique amongst ascomycetous yeasts. Similar to fungal plant pathogens that separated from Saccharomycopsis more than 400 million years ago, a specialized infection structure called penetration peg is used for prey cell invasion. Penetration pegs are highly enriched with chitin. Here we demonstrate that an ancient and conserved MAP kinase signaling pathway regulates penetration peg formation and successful predation in the predator yeast S. schoenii. Deletion of the MAP kinase gene SsKIL1, a homolog of the Saccharomyces cerevisiae ScKSS1/ScFUS3 and the rice blast Magnaporthe oryzae MoPMK1 genes, as well as deletion of the transcription factor SsSTE12 generate non-pathogenic mutants that fail to form penetration pegs. Comparative global transcriptome analyses using RNAseq indicate loss of the SsKil1-SsSte12-dependent predation response in the mutant strains, while a methionine starvation response is still executed. Within the promoter sequences of genes upregulated during predation we identified a cis-regulatory element similar to the ScSte12 pheromone response element. Our results indicate that, re-routing MAP-kinase signaling by re-wiring Ste12 transcriptional control towards predation specific genes contributed to the parallel evolution of this predacious behaviour in predator yeasts. Consequently, we found that SsSTE12 is dispensable for mating.
Introduction
Authors: Jancovich Mark
Published: August 2024

An introduction to the latest issue of Horror Studies, which also considers the current crisis in higher education and argues that its needs to be understood in a wider context, both in terms of history and of the more general attack on expert knowledge. In the process, it argues that a defence of higher education will not be achieved by dreams of going back to a golden age in the academic past, or without a broader fight against the resurgence of the far right internationally. The introduction also provides a brief outline of the various articles featured in the current issue.
‘I don’t feel like a man’: Gender and sexuality in Wes Craven’s Cursed and My Soul to Take
Authors: Brown Shane
Published: August 2024

Wes Craven directed just four feature films in the final decade and a half of his life. Three of them were mainstream horror movies: Cursed (2005), My Soul to Take (2010) and Scream 4 (2011). Both Cursed and My Soul to Take were received poorly by both critics and audiences alike. While they drew heavily on themes and imagery from Craven’s past films, there were also some significant differences, most notably that they both centred primarily on a male rather than female protagonist. The male characters that take centre stage are not the traditional jock-type found in many teen horror movies. This article will examine the role that masculinity and sexuality plays within these two often-neglected films, and how they connect within the wider context of other mainstream teen horror films of the late 1990s and early 2000s that also feature gay characters and/or presentations of non-traditional masculinity. It will demonstrate that the progressive attempts in Cursed and My Soul to Take to feature more prominent and complex characters of this nature are undermined by both the simplistic writing and the apparent disconnect between director and intended audience – a disconnect that had not been present less than a decade earlier.
Medical materials as a therapeutic tool in art therapy
Authors: Greenboim-Zimchoni Adi
Published: August 2024

Using medical materials as an art therapy tool for hospitalized youth is a growing trend in paediatric care. This approach recognizes that young people’s hospital experiences can be overwhelming and anxiety-inducing. However, tools to help them regain control and engage in their care can positively affect their well-being. This article explores a brief (one-session) art therapy process aimed at helping restore a sense of control and safety for youth (3–18 years) in an in-hospital school setting. It describes symbolic art-making with medical materials during brief art therapy sessions using four techniques – self-portraits, therapeutic dolls, animal forms and ‘magic wands’ – and offers illustrative examples of the author’s art created in response to/mirroring of her young patients. Although more research is needed to prove its effectiveness, the described process appears therapeutic, providing positive coping strategies, decreasing anxiety and stress and enhancing the overall hospital experience for hospitalized young people.
Karakteristik Klinis dan Faktor-faktor yang Berpengaruh pada Luaran Pasien di Unit Perawatan Intensif Anak Level Sekunder di Rumah Sakit Umum Daerah Tipe B
Authors: Angelina Angelina , Aviana Ruthie , Ardelia Yolanda , Dewi Arfianti Chandra
Published: August 2024

Latar belakang. Setiap unit perawatan intensif anak (UPIA) memiliki karakteristik berbeda dan evaluasi terhadap luaran pasien penting untuk memperbaiki kualitas pelayanan. Data publikasi penelitian terkait UPIA umumnya dikerjakan pada level tersier.Tujuan Mengetahui karakteristik klinis, luaran, serta faktor-faktor yang memengaruhi luaran di UPIA level sekunder pada Rumah Sakit Umum Daerah (RSUD).Metode: Penelitian potong lintang retrospektif menggunakan data rekam medis pasien yang dirawat di UPIA RSUD Balaraja selama tahun 2022. Data yang diambil mencakup data demografis (usia, jenis kelamin, berat badan), ruang asal perawatan, diagnosis utama, komorbiditas, terapi selama perawatan, dan parameter laboratorium. Hasil uji statistik disajikan dalam nilai p serta interval kepercayaan 95%, besarnya hubungan dinyatakan dengan nilai odd ratio (OR).Hasil: Seratus satu pasien masuk dalam penelitian. Sebagian besar berusia di bawah 1 tahun, berasal dari bangsal perawatan, dan memiliki komorbiditas. Sebanyak 87,1% pasien memiliki diagnosis utama medis, pneumonia dan infeksi sistem saraf pusat merupakan diagnosis terbanyak. Terdapat 32 pasien (31,6 %) meninggal dunia, penggunaan ventilator mekanik (OR 36,75; 95% KI 8,014-168,519; p<0,001) dan pemberian obat vasoaktif (OR 11; 95% KI 4,137-29,295; p<0,001) berhubungan bermakna dengan tingkat mortalitas. Kesimpulan: Sebagian besar pasien adalah bayi yang didominasi dengan masalah medis akibat infeksi. Tingkat mortalitas cukup tinggi, berhubungan bermakna dengan penggunaan ventilator mekanik invasif serta obat vasoaktif.
Os impactos ambientais dos “Maritime Autonomous Surface Ships” (MASS)
Authors: Zanella Tiago Vinicius
Published: August 2024

Os meios autônomos já são uma realidade a ser considerada pelo direito e pela sociedade internacional. Em pouco tempo serão também uma realidade em todos os oceanos no mundo. Diante disso, é de extrema importância que os organismos internacionais, os Estados e a sociedade internacional estejam preparados para estes navios autônomos, que trazem novos desafios ao transporte marítimo internacional e ao direito do mar como um todo. Um destes desafios é justamente quais serão os impactos ambientais que estes “Maritime Autonomous Surface Ships” (MASS) trarão consigo. Isto é, quais as consequências para o meio ambiente marinho destes meios autônomos? É justamente este o objetivo do presente artigo, entender os impactos ambientais dos MASS e quais os novos desafios que a humanidade terá que enfrentar com o eminente advento destes navios. Neste sentido, o texto analisou quais as vantagens e desvantagens destas embarcações para o meio ambiente e, em especial, quais os cuidados o conjunto que a sociedade internacional precisa ter para proteger e preservar o meio marinho com estas novas tecnologias.
Nolfa Ibáñez y su preocupación por la inclusión y la interculturalidad en educación
Authors: Escudero Jaime Caiceo
Published: August 2024

La preocupación por la inclusión en educación ha sido recurrente en los últimos treinta a cuarenta años, tanto a nivel internacional como nacional porque en la cultura actual no es posible aceptar la segregación en el ingreso a los jardines, escuelas, liceos o colegios de infantes, niños, niñas, adolescentes y jóvenes por su situación socioeconómica, étnica o por trastornos específicos, ya sean transitorios o permanentes. La preocupación por la interculturalidad en educación también ha comenzado a considerarse en las últimas décadas en el país por el problema mapuche encubierto por más de un siglo y por la gran afluencia de inmigrantes en los últimos años. En ese contexto es relevante la labor académica que ha desarrollado la académica Nolfa Ibáñez, quien por su labor investigativa y de acción práctica en ambas materias por más de cuarenta años, tanto en la Universidad Metropolitana de Ciencias de la Educación como en el Ministerio de Educación, fue reconocida con el Premio Nacional en Ciencias de la Educación en el 2021. Producto de sus investigaciones, elabora la propuesta pedagógica Metodología Interaccional Integrativa, MII, que se focaliza en la atención pedagógica a la diversidad del estudiantado y en la importancia de las emociones para el aprendizaje. Este trabajo se circunscribe al paradigma cualitativo con episteme fenomenológica y hermenéutica, pues se describirá y analizará la vida y pensamiento de la Premio Nacional, recurriendo al análisis documental y con un enfoque histórico, considerando fuentes primarias (entrevistas y escritos de la autora) y fuentes secundarias (entrevistas y escritos sobre la autora).
Stilistika dan Tafsir: Memahami Variasi Stile dalam Tafsir Rahmat Oemar Bakry
Authors: Amatullah Nur Afra Afifah Amani
Published: August 2024

The works of tafsir in Indonesia, from before to after independence, reflect the socioeconomic and cultural situations of the writers and readers, as seen by the employment of numerous scripts such as Arabic, Cacarakan, Jawi, Latin, Lontara, and Pegon. This study analyzes style changes in Oemar Bakry’s Tafsir Rahmat, specifically interpreting Q.S. An-Nisā’ [4]: 15-18. This study used a stylistic technique to detect four types of stile variation in Tafsir Rahmat: word choice, sentence type variation, rhetorical writing style, and cross-referencing. The study discovered that, in addition to script, style variety influences the character of tafsir compositions. Although prior research has focused on language, script, and specific themes in tafsir works, the study of stylistic differences in Tafsir Rahmat remains limited. The analysis results reveal that stile changes not only simplify message delivery, but also enhance the beauty of language in interpretation. This study contributes significantly to the study of tafsir by emphasizing the role of stylistic variation in the efficiency of tafsir communication.
IMPLEMENTASI TEORI KARIR DONALD SUPER PADA KARIR YOUTUBER DAN PEGIAT MEDIA DI ERA MILENIAL (STUDI KASUS MAHASISWA BIMBINGAN DAN KONSELING UNIVERSITAS HAMZANWADI)
Authors: Aulia Fitri , Yulianti Dewi
Published: August 2024

Career choices in the millennial era have patterns that are identical to the world of technology, such as content creators, YouTubers, media activists and gamers. The guidance and counseling profession is also not a barrier for students to pursue careers in the world of technology. Based on the findings, there are two students who are pursuing careers such as YouTubers and media activists with 55.7 million subscribers and hundreds of media and video works. This research uses case study method. Data was collected by means of interviews, observation, documentation studies. Based on the results of the study, it was found that (1) these two students became YouTubers and media activists according to their potential, interests and talents. This is what is meant by the positive Self concept meant by Donald Super. Where the positive self-concept seems to be the driving force to form career patterns throughout their lives. This is manifested in totality in every work produced. (2) these two students are in the exploratory stage (15-25 years). Where they have been able to understand a profession with an interest in the talent they have. Although there is potential to develop in other directions.
Keywords: youtuber, media activist, Donald Super’s Career Theory
Comparison of Women’s Perceptions of Violent Extremism between Ambon City and Yogyakarta City
Authors: Ilela Jean Evelyn , Afni Khafsoh Nur , Jemmy Talakua Rizard , Michelot Brun Elenore
Published: August 2024

Women’s vulnerability to exposure to violent extremism must receive serious attention from all groups. This is because extremism spreads easily and quickly, especially with recruitment using social media which is very easy to reach many groups. The location situation and describing the typology of women’s perceptions of violent extremism in Ambon City and Yogyakarta City, and analyzing the factors that influence women’s perceptions of acts of extremism are the objectives of the research carried out. Approach The research method used is the Quantitative Approach using the Independent Sample t-Test. The results of the research show that the factors that influence perceptions on the Knowledge variable in Ambon City have an average of 41.97 and Yogyakarta City has an average of 26.41, then Action in Ambon City has an average of 34.09 and Yogyakarta City 33. 85, Attitudes in Ambon City have an average of 32.10 and Yogyakarta City 30.90, and Reasons in Ambon City have an average of 22.09 and Yogyakarta City 22.51. There are differences in women’s perceptions on the knowledge variable in Ambon City and Yogyakarta City. Women’s perceptions of extreme violence in Ambon City and Yogyakarta City are strongly influenced by the social context and experiences of conflict.
Der Bürgerrat Gemeinsame Verkehrswende in Stadt und Land ‐ ein gesellschaftlicher Diskurs für eine nachhaltige Mobilität
Authors: Schröder Sabine , Rasche Barbara , Thomsen Carlo , Gröschner Stefan
Published: August 2024

Ein entscheidender Faktor bei der nachhaltigen Transformation der Mobilität und der konsequenten Umsetzung lokaler Maßnahmen zur Verkehrswende ist die gesellschaftliche Akzeptanz. Denn die Verkehrswende lässt sich nur gemeinsam als Gesellschaft bewältigen und setzt
die Überwindung gewohnter Verhaltensmuster voraus. Das erfordert eine Veränderungsbereitschaft und einen breiten gesellschaftlichen Diskurs. Der Bürgerrat Gemeinsame Verkehrswende in Stadt und Land der Begleitforschung Nachhaltige Mobilität befruchtet diesen
mit neuen Impulsen.
Forest Plundering in the Forest Management Unit (KPH) Randublatung, Blora Regency: Types of Plundering and the Involvement of External Community Actors
Authors: Ulyatin Nazal Chilmi , Sulistiyono Singgih Tri , Rochwulaningsih Yety
Published: August 2024

This study examines forest plundering in KPH Randublatung involving individuals from outside the forest communities. The Reformation era marked the beginning of numerous demonstrations in both urban and rural areas across various regions. In forest villages where communities have close geographical proximity to state forests, one form of particularly intense demonstration was forest plundering. As residents of forest villages, or communities living near KPH, they have engaged in the practice of mblandongeven since the colonial period. Acts of taking wood from state forests have occurred for a long time. However, in the lead-up to the Reformation, taking wood from the forest evolved beyond mere theft, escalating into acts of plundering. This study analyzes the factors driving forest plundering, which also involved parties from outside the forest villages. The research findings indicate both internal (village community) and external factors contributing to the plundering. Internal factors include community customs, perceptions, and the necessity for survival amidst an environment that does not guarantee livelihood sustainability. External factors include political instability in the lead-up to the Reformation, which created opportunities for plunderers due to the absence of legal certainty. Additionally, the emergence of financiers driven by the demand for teak wood in the market also fueled organized and structured plundering. These actions were often supported by security forces.
THE EFFECT OF CORPORATE RISK IN MEDIATING THE RELATIONSHIP OF SUSTAINABLE FINANCE ON CORPORATE PERFORMANCE
Authors: Rampisela Dominggus Richardo
Published: August 2024

The purpose of this study is to analyze the impact of Sustainable Finance mediated by Company Risk on Company Performance for the period 2015 to 2019. Sustainable Finance is calculated using the SFD value (total value of sustainability disclosures) with POJK 51. Corporate risk is calculated using the NPL ratio. Company performance is calculated using the EVA ratio. Meanwhile, Bank Size is calculated using the total asset logarithm. The population in this study are banking companies listed on the Indonesia Stock Exchange during the 2015-2019 period. The research sample was taken using the saturated sample technique. The data used in this study is secondary data, namely in the form of company financial statements that have been audited and obtained through access to www.idx.co.id. This research method uses the PLS research method. The results of the study show that Sustainable Finance has a significant negative effect on Company Risk and Corporate Risk has a negative impact on Company Performance. Also, Sustainable Finance mediated by Company Risk has a significant positive effect on the Company's Performance.
Psychotherapy Supportive Practice For Borderline Personality Disorder (A Clinical Module Development)
Authors: Wardani, SpKJ Natalia Dewi , Widiastuti M I , Sudiyanto Aris - , Hardian Hardian - , Lukman Petrin Redayani , Septiawan Debree - , Primada Lyla Fitrania , Uminah Uminah - , Rasyad Ula Faza Nayli
Published: August 2024

ABSTRACTBackground: Handling patients with Borderline Personality Disorder (BPD) who are hypersensitive to rejection, have unstable interpersonal relationships, self-image, affect, and behavior is a challenge for a psychiatrist. Supportive psychotherapy is one of the most widely mastered psychotherapy modalities in psychiatric education in Indonesia and is most widely practiced in psychiatric services.Objective: It is hoped that the development of a supportive psychotherapy clinical practice module for Borderline Personality Disorder will be helpful for psychiatrists in the handling of Borderline Personality Disorder patient.Methods: This research was conducted in three stages. Stage 1 was preparing the supportive psychotherapy module for 13 weeks. Stage 2 was for the module validation using face validity and content validity by two psychotherapy consultants. Stage 3 was the trials of the developed modules, where 2 interrater therapists applied the modules to treat 5 patients.Result: The face validity of the two experts for the supportive psychotherapy module for Borderline Personality Disorder in Indonesian language was 3.269, meaning that it mostly was done correctly. The results of the content validity of the two experts for the supportive psychotherapy module for Borderline Personality Disorder in Indonesian language was 81.165. The results of the two experts' face validity and content validity scores inferred that the supportive psychotherapy module for Borderline Personality Disorder in Indonesian language was suitable for use in services.Conclusion: Supportive psychotherapy module in Indonesian language for BPD is acceptable to be applied to treat Borderline Personality Disorder patients.
Association of CYP2A6 gene related to the characteristic carcass, commercial cuts, quality of meat and cholesterol of lamb meat
Authors: Istiqlal R. F. , Listyarini K. , Jakaria J. , Budiman C. , Gunawan A.
Published: August 2024

As meat-producing livestock, sheep are a benchmark for communities seeking quality and healthy meat. The CYP2A6 gene has emerged as a potential tool for improving lamb meat quality. This study investigated the genetic variability of the CYP2A6 gene and its association with key determinants of lamb meat quality. The research involved 140 male sheep from five breeds: Javanese thin-tail sheep (JTTS), Garut sheep (GS), Jonggol sheep (JS), Barbados cross sheep (BCS), and Compass agrinak sheep (CAS). PCR-RFLP was employed to identify CYP2A6|BsmAI gene polymorphism and the general linear model (GLM) was used to analyze the gene's association with meat quality. The results showed a polymorphism in the CYP2A6 gene (SNP g.49170107 G>T), presenting two genotypes: GG and GT. The analysis results demonstrated that the CYP2A6 gene (P<0.05) significantly correlates with carcass characteristics (live weight, hot carcass weight, carcass percentage, cold carcass weight), commercial cuts, physical meat quality, and cholesterol content. The GT genotype exhibited superior meat quality to the GG genotype, suggesting that the CYP2A6 gene could serve as a valuable genetic marker for enhancing lamb meat quality.
Fat supplementation containing high palmitic acid enriched with lecithin on the performance, egg quality, and fatty acid profile of quail
Authors: Yano A. A. , Hermana W. , Retnani Y. , Syarif I.
Published: August 2024

This study examined the effects of fat supplementation with high palmitic acid enriched with lecithin on the performance, egg quality, and fatty acid profile of quails. This study applied a completely randomized design to 330 female quails (Cortunix cortunix japonica) which were allocated into 5 different groups with 3 replicates of 22 birds. The groups were assigned as follows: T0 = commercial diet (control), T1 = commercial diet + 2.5% fat + 6% lecithin of added fat, T2 = commercial diet + 2.5% commercial fat, T3 = commercial diet + 5% fat + 6 % lecithin of added fat, T4 = commercial diet + 5% commercial fat. The results showed that the treatment group did not give effects on performances. However, the treatment group with fat level of 2.5% and 5% increased the score of egg yolk and eggshell thickness. Moreover, the treatment group decreased fat content in terms of saturated fatty acids and n-6/n-3 ratio of quail eggs. In conclusion, fat supplementation containing high palmitic acid enriched with lecithin proves effective in improving egg quality. However, the performance remains relatively similar across the groups.