bluuebunny/crossref_metadata_2025 huggingface dataset:
Involvement of interferon-gamma and tumor necrosis factor-alpha in the formation of unstable atherosclerotic plaque
Authors: Snegova Vlada A. , Pigarevsky Peter V. , Maltseva Svetlana V. , Yakovleva Olga G.
Published: September 2024

Research on the role of various interleukins in atherosclerosis has shown that pro-inflammatory cytokines contribute to disease progression and destabilization of atherosclerotic plaques. The review presents the latest data from the scientific literature and the study’s own findings on the effects of pro-inflammatory cytokines INF-γ and TNF-α on the formation of unstable atherosclerotic lesions. It has been shown that the deterioration of the unstable plaque cap strength and its destruction can be associated with an increase in concentration, activation and action of powerful pro-inflammatory cytokines INF-γ and TNF-α in the vascular wall.
Glutamate decarboxylase and its isoforms
Authors: Razenkova Valeria A. , Korzhevskii Dmitrii E.
Published: September 2024

The review summarizes current data on the properties, localization and physiological role of GABA synthesizing enzyme, glutamic acid decarboxylase, in mammalian tissues. Due to the high prevalence of the enzyme in the body’s cells and tissues, at the moment there is a large array of scattered experimental data, which needs to be processed and systematized. Presented data demonstrate the involvement of glutamate decarboxylase in different biochemical and physiological processes of the body. It has been demonstrated that the role of enzyme as the major component of the GABAergic neurotransmission in the central nervous system is the most intensively studied. However, there is only limited information regarding distribution and functional role of glutamate decarboxylase in the peripheral nervous system, and therefore requires additional research.
Materialism and Tourism Brand Attachment in Influencing Compulsive Buying for Generations Y And Z Travel in the Post-Covid 19 Pandemic Period
Authors: Sudiyandi Sudiyandi , Praharjo Ardik , Parwati Kardina Yudha , Alam Aminullah
Published: September 2024

This study aims to analyze the effect of materialism and tourism brand attachment on compulsive buying for travel in generations Y and Z in Indonesia. This study also to analyse the influence of the predecessors of materialism and compulsive buying such as SNS advertisement, celebrity endorsement, and ideal self-congruence. This research is an explanatory research with a quantitative approach. A survey using a questionnaire was conducted to collect primary data in this study. The population in this study is all Y and Z generations in Indonesia. The sample in this study was determined using a non-probability sampling method because the total population is not known with certainty. The sampling technique used was purposive sampling with the criteria (1) maximum birth in 1981, because the research wanted to explain about compulsive buying in generations Y and Z, (2) active users of social media or social network services (SNS), because this research wanted explain the effect of variables related to the use of SNS such as SNS advertisement, celebrity endorsement, and ideal self-congruence on compulsive buying. The number of respondents in this assessment was 250 respondents. The data obtained was then analyzed using Covariance Based Structural Equation Modelling.
Construção de um Curso Online Conectivista: a Wikiversidade no Ensino da Saúde Auditiva
Authors: Arrigo Adriano J. , Peschanski João Alexandre , Girardi Jr. Liráucio , Jurno Amanda Chevtchouk , Jacob Lilian Cássia Bórnia
Published: September 2024

Este relato de experiência aborda o desenvolvimento inicial de um Curso Online Aberto e Massivo Conectivista (cMOOC) intitulado "Introdução à Audiologia Básica" que explora as integrações potenciais entre as plataformas Wikiversidade e Wikipédia no uso de metodologias ativas na área de saúde auditiva. O cMOOC é um projeto-piloto organizado pela Faculdade de Odontologia de Bauru - Universidade de São Paulo em parceria com quatro Universidades de três diferentes regiões do Brasil (sul, sudeste e nordeste) e uma do Canadá (Universidade de Montreal), com apoio do Wiki Movimento Brasil. Trata-se de um relato descritivo e exploratório que visa avaliar a fase inicial de desenvolvimento do cMOOC "Introdução à Audiologia Básica" e examinar as estratégias e resultados da implementação de atividades educativas abertas e colaborativas na área da Audiologia. Serão apresentados o desenvolvimento dos princípios da teoria conectivista, a descrição detalhada do projeto-piloto do cMOOC, destacando as estratégias e resultados da implementação das atividades educativas e exemplos de como a Wikiversidade e a Wikipédia foram integradas como plataformas educacionais.
 
Palavras-chave:Saúde pública. Wikimedia. Colaboração. MOOC.
Influencia de enmiendas calcáreas sobre el rendimiento y calidad para fritura de la papa variedad Bicentenaria
Authors: Sifuentes Zorrila Diana , Palomares Anselmo Edison , Vargas Luna Luis Primitivo , Contreras-Liza Sergio , Macavilca Ticlayauri Edwin , Jhoncon Kooyip Jorge
Published: September 2024

The quality of potatoes for processing depends on varietal, environmental and crop management factors, and the consumption of potato products has increased.The objective of the research was to determine the effect of calcareous amendments on the production and frying quality of potatoes potato cv. Bicentenaria under high Andean conditions.  The research was carried out in the rural community of Canín at Checras district (Lima) altitude of 3880 masl. The climate of the locality is humid and cold, with an annual rainfall of 800 mm and acid soils (pH 5.0) of sandy-clay texture. Five liming treatments and a control without liming were applied to the soil (agricultural lime 500 kg ha-1 and carbonatite 500, 1000, 1500 and 2000 kg ha-1). Agronomic and biochemical characteristics of the tuber were evaluated and sensory analysis was performed for potato frying. Data were analyzed statistically and the Scott-Knott test was used to compare treatment means. Liming with carbonatite 1500 kg ha-1 statistically outperformed the other treatments in tuber weight and was similar to the control; treatment with carbonatite 1000 kg ha-1 had a greater effect on mean tuber weight. The treatments with agricultural lime or carbonatite significantly reduced (p <0.05) the glucose content in the tuber with respect to the control. Sensory tests were significant for liming treatments for chip color. Soil liming influenced some agronomic characteristics and biochemical parameters of the tuber, as well as the sensory evaluation of potato chips.
ЕКОЛОГО-ЕКОНОМІЧНИЙ ЕФЕКТ РЕГЕНЕРАЦІЇ ВІДПРАЦЬОВАНИХ ОЛИВ МЕТОДОМ ЇХ ВІДСТОЮВАННЯ
Authors: Карпенко Сергій Володимировіч , Пузік Сергій Олексійович , Вапнічний Артур Борисович
Published: September 2024

Розглянуто еколого-економічну проблему від застосування некондиційних нафтопродуктів та виявлено, що відстоювання олив від частинок забруднення – перша і обов’язкова операція процесу регенерації. Аналітично досліджена динаміка частинок забруднення при відстоюванні та масі температурного режиму. Визначено закономірність працездатності гравітаційних очисників. Запропоновані схеми підключення гравітаційного очисника в технологічні лінії регенерації відпрацьованих олив.
ДОСЛІДЖЕННЯ ВОДНЕВОГО ЗНОСУ ВАЖКОНАВАНТАЖЕНИХ МЕТАЛЕВИХ ФРИКЦІЙНИХ ЕЛЕМЕНТІВ ГАЛЬМ
Authors: Вольченко Дмитро Олександрович , Кіндрачук Мирослав Васильович , Скрипник Василь Степанович , Журавльов Дмитро Юрійович , Романів Микола Миколайович
Published: September 2024

В матеріалах статті розглянуті наступні питання стосовно до розв'язуваної проблеми: побудова кристалічних граток металів і їх параметри; оцінка стану атомів в кристалічній решітці металу з позицій молекулярної динаміки; напружено-деформований стан гальмівних дисків і осередки водневого зношування їх робочих поверхонь. При дослідженні металевого фрикційного елемента прийнята модель багатошарової атомної  побудови у вигляді сильфона, який під дією імпульсних питомих навантажень стискає свої гофри. При знятті імпульсних питомих навантажень відбувається розширення багатошарової атомної структури за рахунок внутрішніх сил пружності. Встановлено невідоме раніше явище утворення насиченої воднем зон в приповерхневому шарі металевого елемента тертя (обода, диска) гальмівного пристрою, що містить в своєму тілі «внутрішній» водень, який циркулює між шарами атомів кристалічних граток, що полягає в тому, що при електротермомеханічному терті у водневомістному середовищі відбувається виділення «зовнішнього» водню під тиском при цьому за рахунок імпульсних питомих навантажень, поверхневих температур і їх змінних градієнтів в зонах тертя. Темп протікання процесу стиснення в сотні разів більше темпу протікання процесу розширення багатошарової атомної структури. Під дією імпульсних питомих навантажень виникає великий позитивний градієнт температури спалаху, який в приповерхневому шарі металевого фрикційного елемента перетворюється на негативний градієнт поверхнево-об'ємної температури. При цьому підвищується тиск закачуваного водню, який посилюється за рахунок імпульсних питомих навантажень, стискаючи багатошарову атомну структуру.
Educação 4.0: explorando a integração transformadora da tecnologia na educação básica
Authors: Milan Davi , Gomes Renato Duarte , Lucena João Batista , Santiago Karina de Azevedo , Luz Renato Henrique da , Campos Adriano Ricardo de , Camilo Vanessa Cristina Sossai , Frimaio Fabíola de Fátima Andrade
Published: September 2024

Esta pesquisa aborda a temática da "Educação 4.0: Explorando a Integração Transformadora da Tecnologia na Educação Básica", contextualizando a crescente influência da tecnologia no ambiente educacional contemporâneo. A problemática central reside na necessidade de compreender o impacto da Educação 4.0 na educação básica, considerando questões de acesso equitativo, desenvolvimento profissional dos educadores, novos modelos educacionais e avaliação de impacto. Para abordar essas questões, adotou-se o paradigma neoperspectivista giftedeano, enfatizando a valorização das múltiplas perspectivas e experiências individuais. Além disso, o método hipotético-dedutivo foi empregado, permitindo a formulação de hipóteses sobre o impacto da tecnologia na aprendizagem dos alunos. A pesquisa conduziu uma Revisão Bibliográfica e Documental Narrativa para analisar criticamente a literatura existente, identificando tendências, desafios e oportunidades. Os principais achados destacaram o impacto significativo da tecnologia na experiência de aprendizagem dos alunos, mas também ressaltaram a necessidade de abordar as disparidades no acesso equitativo à tecnologia e promover o desenvolvimento profissional dos educadores. As lacunas encontradas incluem a falta de estudos longitudinais e empiricamente robustos sobre o impacto da Educação 4.0, assim como a necessidade de mais pesquisas sobre estratégias eficazes para avaliação de impacto. As contribuições da pesquisa incluem uma síntese abrangente da literatura existente e insights para futuras pesquisas sobre o potencial transformador da tecnologia na educação básica
Profit Comparison of Computer System with Hardware Redundancy Subject to Different Repair Activities
Authors: MUNDAY VIKRAM , Permila
Published: September 2024

In this research paper, main concentrate of the authors on the profit comparison of computer system with hardware redundancy by introducing the concept of priority to software up-gradation, hardware preventive maintenance (PM) and hardware maximum repair time (MRT). The system fails independently from normal mode. All the repair activities such as hardware repair, software up-gradation, hardware preventive maintenance before failure and hardware replacement after maximum repair time are carried out by a single server immediately on need basis. All random variables are statistically independent. The negative exponential distribution is taken for the failure time of the component while the distributions of repair time, up-gradation time, preventive maintenance and replacement time are assumed arbitrary with different probability density functions. Semi-Markov process and regenerative point technique are used. The behaviour of profits of the system models have been examined for different parameters and costs.
Łódź w polskiej powieści młodzieżowej XXI wieku
Authors: Berkan-Jabłońska Maria
Published: September 2024

Artykuł jest próbą analizy czterech wybranych powieści młodzieżowych powstałych w ostatnich dwóch dekadach, których akcja rozgrywa się w Łodzi. Poddany analizie zbiór tworzą tytuły: Syn złodziejki Grażyny Bąkiewicz oraz Piąta z kwartetu, Możesz wybrać kogo chcesz pożreć i The Restaurant Day Doroty Combrzyńskiej-Nogali. Oprócz usytuowania utworów na tle dotychczasowej prozy dla młodego czytelnika związanej fabularnie z Łodzią, omówiono cztery zagadnienia współtworzące literacki obraz miasta. Po pierwsze, zwrócono uwagę na konkretyzację łódzkich realiów i funkcje motywu wędrówek bohaterów ulicami Łodzi. Po drugie, rozważono sposób pokazania stosunków rodzinnych i zjawisko odwrócenia ról, zestawiając je z tezami historyków na temat sytuacji dzieci łódzkich w przeszłości. Po trzecie, wskazano na ciekawą i powracającą wizję miasta jako przestrzeni ustrukturyzowanej wielowarstwowo. Na koniec wykorzystano pojęcie palimpsestu, odnosząc je do obrazu Łodzi funkcjonującej równolegle w sferze realnej i w sferze pamięci. Naświetlone tu sposoby tekstualizacji Łodzi prowadzą do wniosku, że literatura młodzieżowa, choć nie jest wolna od stereotypowego obrazu miasta niechcianego, szaro-buro-przestępczego, proponuje także inną jego koncepcję – miasta „swojego”, „mocnego”, z którym łączą bohaterów ważne, choć czasem trudne więzi i którego nie chcą opuszczać.
Karykaturalny wizerunek Wilhelma II w europejskiej i polskiej prasie satyrycznej w latach 1888–1914
Authors: Rydz Romuald
Published: September 2024

Druga połowa XIX stulecia była w Europie okresem gwałtownego rozwoju prasy satyrycznej, która szybko stała się ważnym narzędziem kształtowania opinii publicznej. Wraz z rozwojem technologii drukarskich jedną z głównych form oddziaływania tego rodzaju pism stały się rysunki satyryczne – karykatury. Dzięki wykorzystaniu humoru, jaki niosły ze sobą tego rodzaju wytwory wydawcy periodyków satyrycznych mogli ze swymi przekazami dotrzeć do znacznie szerszego grona czytelników niż było to wcześniej. Na popularność prasy satyrycznej wpłynęła też tematyka jaka była poruszana przez twórców karykatur. Choć początkowo sięgali głównie po treści obyczajowe, to z biegiem czasu ważne okazały się dla nich zagadnienia polityczne. W szczególności karykaturzyści zajęli się przedstawianiem w krzywym zwierciadle osób zaangażowanych w walkę i sprawowanie władzy. Z tego powodu przedmiotem ich zainteresowania okazali się stojący na czele państw monarchowie. Wśród władców europejskich wyjątkowe emocje satyryków budził, od początku swego panowania, cesarz Niemiec Wilhelm II. Ze względu na swoje cechy charakteru, styl sprawowania rządów oraz imperialne ambicje stał się bohaterem licznych karykatur drukowanych w Europie i Ameryce Północnej. Także polskie pisma satyryczne poświęcały mu sporo uwagi. Wiele z nich publikowało karykatury Wilhelma, które inspirowane były jego działaniami na arenie międzynarodowej. Jednak tym, co wyróżniało polskich karykaturzystów na tle europejskim było wykorzystanie przez nich wątków związanych z polityką niemiecką wobec polskiej społeczności w zaborze pruskim. W efekcie karykatury Wilhelma i poświęcone mu publikacje satyryczne przyczyniły się do utwierdzenia jego wizerunku jako osoby odpowiedzialnej za działania germanizacyjne i problemy Polaków na początku XX w.
Ironia vs sarkazm „Przewodnika po Krakowie” Kazimierza Bartoszewicza w kalendarzu humorystycznym „Ananas” z 1889 roku
Authors: Glugla Paweł
Published: September 2024

Jednym z najczęściej wskazywanych polskich autorów przełomu XIX i XX w. w zakresie ironii, sarkazmu, humorystyki był Kazimierz Bartoszewicz. Można go nazwać mistrzem w tym zakresie. Jego szerokie zainteresowania, wszechstronna działalność publicystyczno-wydawniczo- polityczna, a także patriotyczna zasługują na uwagę. W tekście została dokonana próba zarysu jego niepospolitego talentu na przykładzie tekstu Przewodnik po Krakowie. W publikacji tej o cechach ironiczno-sarkastycznych, w humorystyczny sposób przedstawił czytelnikom zalety i wady zarówno miasta, jego infrastruktury, funkcjonowania różnorodnych instytucji, nazewnictwa ulic, obiektów, a w szczególny sposób mieszkańców i zarządzających grodem. Należy pamiętać, że był to czas niewoli narodowej, a tego typu publikacje miały na celu również wyrwanie ludzi z powszechnego marazmu i niemożności. Bartoszewicz był mistrzem w swoim fachu. Jako księgarz i wydawca dzieł historycznych pisywał celne, humorystyczne wiersze i wydawał równie świetny kalendarz humorystyczny „Ananas”. Wiele z jego diagnoz sytuacyjno-osobowych i ocen nie straciło również dzisiaj na swojej aktualności. Zawdzięczał to swojemu bystremu umysłowi, inteligencji, niepospolitemu zmysłowi postrzegania i celnemu analizowaniu wydarzeń, zachowań i ocen. Najważniejsze – nie był przy tym pamflecistą i paszkwilantem. Z biegiem lat wyrobił swój specyficzny styl i klasę. Wrodzony talent, tradycja rodzinna i rozległe naukowe przygotowanie predestynowały Bartoszewicza do pracy publicystyczno-redakcyjno-satyrycznej.
Humor i satyra w prasie Polonii amerykańskiej (do 1918 roku). Przegląd problematyki
Authors: Kiper Daniel
Published: September 2024

Artykuł stanowi przekrojową charakterystykę prasy satyrycznej i humorystycznej Polonii amerykańskiej w latach 1886–1918. Na wybranych przykładach pokazano, w jaki sposób czasopisma satyryczne Polonii amerykańskiej starały się zaspokajać potrzeby masowego odbiorcy i oddziaływać na niego ideologicznie. Wydawcy polonijni zmuszeni byli dostosowywać wydawane przez siebie pisma humorystyczne do swojej wizji świata i oczekiwań odbiorców. Nie konkurowali z pismami amerykańskimi, ale starali się znaleźć odrębną niszę w ówczesnym makrokosmosie medialnym i rozwijać ją niezależnie od głównego nurtu. Aby zachować potoczny styl w przekazie medialnym, starano się równoważyć konwencje językowe, formy dziennikarskie i materiał ilustracyjny tak, aby były zrozumiałe nie tylko dla pierwszego pokolenia emigrantów, ale przede wszystkim dla przedstawicieli Polonii urodzonych w Nowym Świecie, którzy uczyli się amerykańskiego humoru.
Humor i satyra na polowaniu na podstawie czasopism „Łowiec Polski”, „Łowiec Wielkopolski” oraz archiwów ziemiańskich
Authors: Studnicka-Mariańczyk Karolina , Hubicki Piotr
Published: September 2024

Polowanie towarzyszyło człowiekowi od zarania dziejów. Historia polowań przeplata się bezpośrednio z historią społeczeństwa. Wraz ze zmianami społecznymi i cywilizacyjnymi rozwijał się towarzyski aspekt myślistwa, co dawało okazję do żartów i zabawnych opowieści. Celem artykuł jest ukazanie myśliwskiego humoru i satyry obecnych w drugiej połowie XIX w. Jako materiał badawczy posłużyły archiwalia ziemiańskie – opowiadania, wierszyki i rymowanki związane z polowaniami. Wykorzystano także zabawne opowiadania, które ukazywały się łamach czasopism specjalistycznych „Łowca Polski” i „Łowca Wielkopolski”.
Wątki humorystyczne w „Wierszach” Stanisława Apolinarego Zambrzyckiego
Authors: Karpiński Ignacy
Published: September 2024

Tematem artykułu jest humorystyczny, satyryczny i ironiczny aspekt wierszy napisanych przez Stanisława Apolinarego Zambrzyckiego, polskiego ziemianina żyjącego w latach 1824–1908 w majątku Wiazynka w guberni mińskiej Cesarstwa Rosyjskiego. Wiersze powstawały od lat sześćdziesiątych XIX w. do śmierci poety w 1908 r. W pracy przedstawiona jest historia rodu autora wierszy, jego status społeczno-materialny, osobowość oraz środowisko, w którym żył. Przekrojowo zostały ukazane fragmenty wierszy opisujących ważne wydarzenia w życiu autora, ale także sytuacje życia codziennego. Dotyczyły one rodziny, sąsiadów, znajomych oraz całych grup społecznych. Utwory ukazują osobowość, mentalność, sposób myślenia oraz poczucie humoru polskiego, prowincjonalnego, drobnego, kresowego ziemianina.
Identification of activating somatic mutations in the PIK3CA gene in breast tumors and determination of their minimal set for clinical diagnostic testing
Authors: Boyarskih Ulyana A. , Kechin Andrey A. , Zyuzyukina Alyona V. , Khrapov Yevgeny A. , Oscorbin Igor P. , Alexeenok Yefim Y. , Avdiyuk Galina A. , Zukov Ruslan A. , Kushlinskii Nikolay E. , Filipenko Maksim L.
Published: September 2024

Background: For effective screening of breast cancer patients for candidates for target therapy with alpelisib, it is necessary to identify activating somatic mutations in the PIK3CA gene by allele specific polymerase chain reaction (PCR); this requires that an optimal list of mutations should be compiled.
Aim: To determine the spectrum of somatic mutations in the PIK3CA gene in breast cancer tumors by means of high performance sequencing (next generation sequencing, NGS) and to identify their minimal set for clinical diagnostic testing by allele specific PCR.
Methods: Targeted NGS was used to identify mutations in the PIK3CA gene in DNA obtained from paraffin blocks with tumor material from 431 patients with HR+HER2- breast cancer. A set of the most common somatic mutations was also detected by allele specific PCR.
Results: We have developed a set of reagents and a protocol for targeted NGS of frequently mutating regions of the PIK3CA and ESR1 genes, which was used to analyze samples from 451 HR+/HER2- breast cancer patients. Clinically significant activating mutations in the PIK3CA gene were found in 32.7% of the samples (141/431). The frequency of the mutant allele ranged from 0.15 to 0.65. Six mutations were most common: c.3140AG p.His1047Arg (69), c.1633GA p.Glu545Lys (32), c.1035TA p.Asn345Lys (12), c.1624GA p.Glu542Lys (9), c.3140AT p.His1047Leu (8), Cys420Arg c.1258TC (3). In total, these mutations amounted to 94.3% (133/141). In 3.5% of the samples (15/431), there were clinically significant somatic mutations in the ESR1 gene: c.1613AG p, Asp538Gly (7), c.1610AC p.Tyr537Ser (6), c.1609TA p.Tyr537Asn (1), c.1610AG p.Tyr537Cys (1), causing resistance to hormone therapy in patients with breast cancer. While rare mutations comprised only 5.7% of our sample, we validated a set of reagents to identify the six mutations described above by allele specific PCR. NGS and PCR were completely concordant.
Conclusion: PCR testing of activating somatic mutations of the PIK3CA gene meets the requirements for sensitivity ( 90%) and specificity (100%) for a clinical test and can be used in the selection of patients for targeted therapy with PIK3CA inhibitors.
The post-pandemic intentions of EFL lecturers towards online language teaching
Authors: Rahimi Amir Reza , Mosali Zahra
Published: September 2024

After the widespread transition to Emergency Remote Language Teaching , there is a need to investigate teachers' continued intention toward online language teaching post-pandemic. Thus, DeLone and McLean's model of information systems success was used to investigate university lecturers' attitudes toward OLT during the post-pandemic period. The maximum variation sampling was conducted on fourteen university lecturers from various cities in Iran. A three-phase interview protocol was developed and applied to the participants. The data was analyzed with content analysis. The result of the deductive content analysis showed that OLT helped university instructors overcome technophobia and become experts in it. However, OLT had some health hazards for lecturers and led students to passive learning. Furthermore, the lack of technical, financial, and professional support from the administrators affected OLT service quality. Moreover, participants would have blended and flipped language teaching during the post-pandemic, based on learners' levels and psychological factors. Among many implications, the study suggests more teacher training workshops for university lecturers to overcome technophobia.
Keywords: DeLone and McLean information systems success model; EFL teachers; Online Language Teaching; Post-pandemic.
Pesquisas urbanas em Belo Horizonte:
Authors: Veloso Clarissa dos Santos , Teixeira de Andrade Luciana
Published: September 2024

O objetivo deste artigo é analisar a produção acadêmica na área dos estudos urbanos sobre Belo Horizonte e sua região metropolitana. Foi realizado um levantamento das teses e dissertações produzidas em programas de pós-graduação de Ciências Humanas e Sociais Aplicadas da UFMG e da PUC Minas, no período de 1991 a 2020. Esse corte temporal se justifica, uma vez que o estudo Belo Horizonte em tese, organizado pelos professores Berenice Guimarães e Sérgio de Azevedo, abordou o período anterior. Uma diferença significativa entre os estudos é que o primeiro compreende um período anterior à expansão da pós-graduação no Brasil. Entre as conclusões, pode-se destacar o fato de a cidade de Belo Horizonte ter sido a mais estudada. Já em relação ao recorte temporal das investigações, é notável a preocupação com o tempo presente. A atração pela formação da capital planejada, presente em muitos estudos anteriores, foi substituída por questões urbanas atuais. Em geral, os novos temas dialogam com as políticas públicas urbanas, os movimentos ou as práticas sociais em curso. Nota-se também a manutenção de algumas temáticas já consolidadas na investigação das cidades.
Life-threatening nasotracheal tube obstruction by a blood clot: a case report
Authors: Lee Dajeong , Park Chan Yong , Kim Sang Wha
Published: September 2024

The nasotracheal tube (NTT) is frequently used in oral and maxillofacial surgery and is generally considered a safe means of protecting the airway while ensuring an adequate surgical field. The most common complication associated with NTT is epistaxis, and only a few cases of foreign body obstruction have been reported. In this case report, the authors aimed to highlight the potential for NTT obstruction following surgery. A 24-year-old female patient, who underwent mandibuloplasty and rhinoplasty at a local clinic, was referred to our hospital patient due to dyspnea and edema on her right mandibular angle. Even with NTT, patient continued to experience mild dyspnea and tachypnea, so a T-piece was applied. However, tachycardia accompanied by a sudden worsening of dyspnea was observed, and bag-valve-mask ventilation was initiated promptly. But oxygen saturation remained unimproved, so an emergency cricothyroidotomy was performed. After 4 hours, the patient’s condition stabilized. Upon examination, the previously inserted NTT was identified, and a blood clot approximately 10 cm long at the NTT tip was discovered, causing lumen obstruction. The obstructions of NTT can lead to serious or life-threatening consequences if left unobserved or ignored. Therefore, when a patient with an NTT complains of dyspnea, clinicians should promptly investigate the possibility of partial NTT obstruction to ensure the airway’s security.
Penetrating cardiac injury resulting in a bullet embolus: a case report
Authors: Shihadeh Sammy , Khan Anwar , Walker Kristen , Al-Rawi Ali , Cordova Alfredo
Published: September 2024

Bullet embolism is a potential complication of a gunshot wound, especially with a low-velocity missile.This is because the trajectory of the low-velocity bullet can be significantly slowed as it passesthrough tissue. An unusual form of travel can occur in which the bullet enters the vasculature butdoes not have enough kinetic energy to create a through-and-through wound, leading it to remaininside the vasculature. Once inside the vasculature, the bullet could migrate to different parts of thebody, potentially causing complications such as ischemia, becoming a source of thromboembolism,or functioning as a nidus for infection. The management of a bullet embolism varies from case tocase, as each patient with this issue has a unique body habitus that can result in infinite possibilitiesof the trajectory and destination of the bullet embolus. Additional damage to surrounding vasculatureor tissue can occur, as well as embolization of the bullet to critical areas of the body. Here wepresent the case of a 72-year-old man who had a self-inflicted gunshot wound to the chest with alow-velocity bullet, which penetrated the right atrium of the heart. It traveled into the venous vasculaturethrough the right atrium, into the inferior vena cava, and eventually settled in the right internaliliac vein. He refused further intervention and management after initial workup and resuscitation.
Prevalência de Dependência de Exercício Físico em Praticantes de Programas de Condicionamento Extremo
Authors: Neto Antônio Ribeiro , Magalhães Lucimara Ferreira , Walsh Isabel Aparecida Porcatti de , Bertoncello Dernival
Published: September 2024

Neste estudo, buscou-se determinar a prevalência de dependência ao exercício em praticantes de programas de condicionamento extremo, analisando o impacto na qualidade de vida, o risco de lesões e a sensibilidade à dor. Foram avaliados 368 praticantes de Crossfit® e utilizados os questionários Exercise Addiction Inventory, para avaliar a dependência, o WHOQOL-bref, para avaliar a qualidade de vida, e, para avaliar os riscos de uma possível lesão musculoesquelética, foi utilizado o Questionário de Prontidão para o Esporte com Foco nas Lesões Musculoesqueléticas. Os dados foram analisados pelos testes Shapiro-Wilk, com correlação de Spearman e Odds Ratio (OR) e intervalo de confiança de 95% (IC95%). Todas as análises foram realizadas considerando um nível de significância de 5%. A prevalência de dependência foi de 14,40%, e foi encontrada correlação entre a dependência e o domínio físico (r = 0,125, p= 0,017) e entre o domínio ambiente e a dependência (r = -0,142, p= 0,006).  Foi também encontrada uma associação do positivo para a dependência com o domínio ambiente (OR: 1,094, IC = 1,046-1,143). A prevalência de dependência ao exercício foi de 14,40%. A dependência pode influenciar de forma negativa no domínio ambiente e de forma positiva no domínio físico.
Efeitos da Pandemia de Covid-19 em Amostra de Universitários da Saúde no Norte do Brasil
Authors: Lira Lorena do Rosario , Ferreira Isabela Dias , Carvalho Ana Emília Vita
Published: September 2024

Introdução: A ansiedade, o estresse e a depressão afetam indivíduos de forma diversa. Estudos mostram que estudantes universitários podem ter maior prevalência desses transtornos, e a pandemia de covid-19 pôde ter colaborado para graus mais elevados. Métodos: Trata-se de um estudo transversal, descritivo e exploratório, com análise de dados quantitativos, realizado em uma universidade particular em 2022, que teve como objetivo analisar a prevalência de depressão, da ansiedade e do estresse em universitários da área da saúde que estudaram durante a pandemia de covid-19. Os participantes responderam ao TCLE, Questionário Sociodemográfico e Econômico e Escala de Ansiedade, Depressão e Estresse (EADS-21).  Resultados: Participaram 55 estudantes, de maioria feminina, média de 23 anos, que fazem uso de bebidas alcoólicas, atividades físicas e lazer, não consomem nicotina ou drogas ilícitas. Quanto ao EADS-21, a maioria estava dentro da normalidade em relação à ansiedade e estresse, porém 1/3 da amostra apresentou depressão moderada e grande número de participantes evidenciaram ansiedade e depressão extremamente severos. Discussões: Mesmo tendo hábitos de vida relativamente saudáveis, uma parcela significativa da amostra apresenta sinais de sofrimento psicológico grave. Conclusão: Os resultados do estudo sugerem que, mesmo após o período crítico da pandemia, os universitários da amostra apresentam sinais de sofrimento psicológico.
Cartas político-afetivas contra o racismo na pós-graduação
Authors: De Jesus Victor
Published: September 2024

As Leis n. 10.639/2003 e 12.711/2012 impactaram profundamente as universidades brasileiras, seja pelo aumento expressivo de estudantes negras/os nas universidades, seja pela demanda de um currículo afrocentrado e de docentes negras/os, seja pela inclusão da disciplina de Educação para as Relações Étnico-Raciais nos cursos de licenciatura, para atender às demandas de uma educação básica antirracista. No entanto, a pós-graduação brasileira segue sendo um espaço predominantemente branco, tanto na corporalidade de docentes e discentes quanto nos saberes eurocentrados que marcam o epistemicídio dos conhecimentos produzidos pelas intelectualidades negras. Por isso, este ensaio busca contemplar diferentes experiências-narrativas pessoais na pós-graduação, utilizando da carta como recurso político-metodológico narrativo. Desse modo, assumo minha narrativa autobiográfica enquanto discente, pesquisador e docente para discutir o racismo universitário na pós-graduação a partir da escrita de cartas para a minha orientadora, para as instituições de pesquisa e para as/os discentes da disciplina que ofertei, contextos nos quais a carta adquire finalidades terapêutica-imaginativa, manifesto-interpelativa e/ou pedagógica-afetiva. Por fim, considero que uma educação antirracista passa necessariamente por um currículo afrocentrado ético-político-estético-poético que acolha as experiências-narrativas negras e promova o desenvolvimento humano, intelectual e afetivo em cada sujeito.
Accuracy of intraoral scanners based on jaw curve and inter-implant distance
Authors: Mohialdeen Hasan Khiraldeen , Abdulla Mohammed A. , Al-Noori Ammar Kh. , Mohamad Ashraf Measar
Published: September 2024

Background: In digital dentistry, the intraoral scanner (IOS) is the primary data-collecting device. The data must be accurate to prevent undesirable stresses and technological difficulties resulting from prosthetic misfits. The span length of restorations influences the accuracy of IOS impressions. Purpose: This research aimed to compare the accuracy of virtual models scanned by different IOSs to determine whether jaw curvature and inter-implant distance affect accuracy. Methods: Four mandibular edentulous models were prepared by replacing the site of the missing tooth with an implant. The prepared holes were drilled at 7mm, 14mm, 21mm, and 28mm. Five scans for each model were taken with a desktop laboratory scanner as a reference model and with Trios3Shape and 3Disc Heron IOSs to evaluate trueness and precision (T&P). The scans were saved as standard triangulation language files and statistically analyzed at a level of significance (P ≤ 0.05). Results: There was a significant difference between the IOSs in inter-implant distances (P < 0.05). The greatest distortion was reported in the 21mm and 28mm groups for both scanners (P ≤ 0.05), while the lowest distortion was observed in the 7mm and 14mm groups for the Trios3Shape scanner. Conclusion: Jaw curvature and inter-implant distance impacted the accuracy of the IOS. Distortion and reduced reproducibility of T&P increased with jaw curve and inter-implant distance. The Trios3Shape IOS showed maximum accuracy at 7mm and 14mm inter-implant distances, while the 3Disc Heron IOS produced significant distortion of trueness at 21mm and 28mm inter-implant distances.
The effect of adding ZrO2 nanoparticles on the transverse strength and hardness of microwave-cured acrylic and heat-cured acrylic denture base materials
Authors: Shehab Marwah M. , Hasan Radhwan Himmadi , Aziz Rana Rabee
Published: September 2024

Background: One drawback of acrylic denture base materials is their liability to fracture, requiring methods to increase fracture resistance. Adding nanoparticles (NPs) represented one of these methods. Purpose: The objectives of this study are to evaluate and compare transverse strength and hardness when adding zirconium oxide nanoparticles (ZrO2 NPs) at concentrations of 0%, 3%, and 5% to heat-cured acrylic denture base materials (Ivoclare, Major) and to microwave-cured acrylic (Acron MC). Methods: Transverse strength was tested with a Universal Testing Machine (GESTER, Fujian, China), while hardness tests were conducted by using a Shore-D hardness durometer (Show, China). The 90 samples were prepared and then divided into three groups for each material. Attenuated total reflectance–Fourier transform infrared (ATR-FTIR) spectroscopy was used to analyze the microstructure. The samples were prepared following the manufacturer’s instructions for each material. Results: The results revealed that the addition of ZrO2 NPs (3%, 5%) improves the transverse strength and hardness of polymethyl methacrylate acrylic resin for both types (microwave-cured and heat-cured acrylic resins). The addition of ZrO2 NPs at 3% concentration shows the highest values for both transverse strength and hardness. The ATR-FTIR confirms no structural chemical changes with the addition of ZrO2 NPs. Conclusion: The study concludes that the incorporation of ZrO2 NPs (3%, 5%) into microwave-cured and heat-cured acrylic resins improves transverse strength and hardness.
A novel approach for posterior bite collapse in an adult with crossbite anterior using a 3D-printed bite riser
Authors: Alhasyimi Ananto Ali , Indra Putu , Rosyida Niswati Fathmah , Retnaningrum Yanuarti , Setijanto R. Darmawan , Vázquez-Santos Francisco José
Published: September 2024

Background: Managing an adult patient presenting with an anterior crossbite in conjunction with posterior bite collapse (PBC) is a difficult challenge. Purpose: The purpose of this case study is to highlight the accuracy that can be attained with the utilization of a three-dimensional (3D) printed bite riser in the correction of PBC accompanied by an anterior crossbite in an adult patient with Class III malocclusion. Case: A 64-year-old male complained of being unable to chew properly. Extraoral examination revealed a concave profile with a protrusive mandible. The patient exhibits a 5 mm anterior crossbite and has missing lower posterior molars, resulting in bilateral PBC. The cephalometric analysis revealed skeletal Class III patterns (SNA: 82.19o; SNB: 86.34o; ANB: -4.15°), with protrusion and counterclockwise rotation of the mandible (SN-OP: 3.84o). Case Management: By utilizing a 3D-printed bite riser in conjunction with temporary anchoring devices (TADs), it is possible to resolve the issue of an anterior crossbite accompanied by PBC. This is achieved by repositioning the elongated posterior segments on both sides of the maxilla to generate vertical space for mandibular tooth rehabilitation, retracting the anterior segment, and narrowing the lower arch. Simultaneously, the crossbite on both sides was corrected, a Class I and ideal overbite and overjet were achieved, the occlusal vertical dimension increased, the occlusal plane angle was corrected (7.51o), and an acceptable ANB angle (-1.36°) was accomplished. The treatment lasted 18 months and yielded sustained results after a one-year retention period. Conclusion: Integrating 3D printing technology in orthodontic treatment offers numerous options for managing challenging cases such as PBC while also reducing the treatment length. The patient was satisfied with the results achieved.
Long-standing pleomorphic adenoma in hard palate: A rare case report
Authors: Hanafiah Olivia Avriyanti , Dohude Gostry Aldica , Ayuni HG Afifah , Tanandika Janesia , Wirsa Dinda Andaru
Published: September 2024

Background: Pleomorphic adenoma (PA) is the most common benign tumor of the parotid gland, followed by the submandibular gland, and rarely in the minor salivary glands. However, it has the potential to turn malignant. The minor salivary gland in the hard palate is a rare site for PA. Purpose: This report aims to describe the clinical and histopathology findings and treatment with surgical excision of long-standing PA on the hard palate. Case: 40-year-old woman with an asymptomatic 6 x 4 x 4 cm hard palate tumor mass that had remained untreated for ten years and had no preceding trauma. Case Management: The tumor mass was removed surgically by creating an excision opening of 2–3 mm between the mass margin and the maxillary bone periosteum, extending to the posterior palate. Histopathology findings confirmed the diagnosis of PA in the minor salivary gland and revealed typical characteristics associated with malignant transformation.  Observation after one month showed that the surgical wound had healed, and no symptoms of recurrence were visible. Conclusion: PA is a benign salivary gland tumor that has the potential to expand extensively. Appropriate surgical excision can improve the prognosis.
Growth Performances and Productivities of Kappaphycus alvarezii and Eucheuma spinosum Cultivated with Long-line Method in PT. Sea Six Energy Indonesia
Authors: Chairun Nisa Andina , Jatayu Diklawati , Alfiani Putu Putri
Published: September 2024

Indonesia is the second largest producer of seaweed in the world. Different cultivated seaweed commodities may have different production results. This study aimed to determine the effect of cultivation time and different types of seaweed on total weight and Specific Growth Rate (SGR) of Kappaphycus alvarezii and Eucheuma spinosum cultivated with the long-line method. The study was conducted in one cultivation area, PT. Sea Six Energy, Bali, Indonesia. Data collection was carried out through observations in 2 sites. Every site contained 3 square frame seaweed Kappaphycus alvarezii and Eucheuma spinosum. The sample used in this study was one thallus of seaweed taken randomly from 3 different ris ropes in each square frame. The average weight of thallus, total weight, and specific growth rate were performed in this study. After 51 days, the total weight of K. alvarezii was 1348.5 kg. The total weight of E. spinosum was 1398.7 kg. Both, K. alvarezii (8.4 ± 0.34 %.day-1) and E. spinosum (8.3 ± 0.02 %.day-1) showed higher Spesific Growth Rate (SGR) in the first 2 weeks of planting but not in the last 3 weeks of cultivation. There was no difference in productivity between K. alvarezii and E. spinosum cultivated using the long-line method. However, this research showed that the SGR value decreased as cultivation time increased.
A quasi-experimental study of trigger films for teaching the doctor-patient relationship
Authors: Khaliq Farah , Gangwani Nonita , Singh Satendra
Published: September 2024

Background: It is challenging to teach the complexity of the doctor-patient relationship through attitude, ethics, and communication (AETCOM) modules, particularly without being formally trained and especially to first-year medical students who do not interact directly with patients. The present study was undertaken to assess the effectiveness of trigger films (TFs) or short movie clips as a teaching-learning tool to train undergraduate medical students on various aspects of doctor-patient relationships. Methods: Two modules on various aspects of the doctor-patient relationship were developed using TFs and written case studies and implemented on Phase Ⅰ medical students. Quantitative and qualitative feedback were collected from learners. Perception, understanding, and knowledge were assessed using pre- and post-questionnaires. The results of the feedback and questionnaires collected after using TFs were compared with those collected after using written case studies. Results: There was a gain in knowledge and understanding after TF sessions, and TF sessions were rated much higher by the students than traditional methods. Most students found TFs to be an innovative and interesting tool. The satisfaction index calculated for TFs from the feedback of both students and teachers was above 96%. Conclusions: TFs engaged the students’ affective domain, promoted reflective attitudes, and linked their learning to experiences. It was reported not only to be interesting and engaging but also effective as a teaching tool.
THE USE OF ENGLISH MEDIUM INSTRUCTION IN MULTILINGUAL CLASSROOMS IN JAPANESE LANGUAGE TEACHING
Authors: Luchenko Olha , Doronina Olha , Chervinko Yevhen
Published: September 2024

Purpose. This article examines the use of English medium instruction (EMI) for teaching Japanese as a foreign language (JFL) by non-native speakers with a focus on multilingual classrooms. It also explores teachers’ positive and negative beliefs about using EMI in classroom settings for JFL instruction. Methods and procedure. 274 non-native Japanese language teachers from around the world (57 countries) voluntarily participated in a survey, answering a questionnaire on Google Forms and Jotform. Both qualitative and quantitative methods were employed. The research instrument was piloted before the main study and was found to be effective and adequate to elicit the desired data. The research questions aimed to identify whether there were any relationships between the use of EMI and the multilingual classroom. Findings. The results showed a clear correlation between the extensive use of EMI and the multilingual character of JFL classrooms. Translanguaging turned out to be a common practice adopted by non-native Japanese teachers regardless of the primary language of instruction. The article concludes that EMI can be a valuable tool for JFL instruction in multilingual classrooms. Based on the investigation of the teachers’ beliefs, the results showed a changing positive attitude towards English employed in JFL classrooms. Implications for research and practice. The findings can be used to further investigate EMI in JFL instructional practices in multilingual classrooms, improve the quality of JFL instruction and facilitate the integration of multilingual education into foreign language teaching. Future research can explore the effectiveness of EMI in different JFL contexts and investigate the impact of EMI on students’ language learning outcomes.
The efficacy of autologous serum therapy in chronic spontaneous urticaria: A systematic literature review and meta-analysis
Authors: Suherman Ahmad Ligar , Nopriyati  , Pariyana
Published: September 2024

Chronic spontaneous urticaria (CSU) is an autoimmune disease characterised by urtica lesions and/or angioedema accompanying an itching sensation, recurring for at least six weeks without any specific trigger. Autologous serum therapy (AST) is an adjuvant therapy for CSU that is resistant to H1 antihistamines. This therapy is an economical option in developing countries. There were a few studies discussing the role of AST in CSU. This systematic review and meta-analysis were conducted to evaluate the efficacy of AST based on urticaria activity scores (UAS or UAS7) and urticaria total severity scores (TSS) so that clinicians can consider them. Data were searched systematically in Cochrane, PubMed, Google Scholar, Willey, and EMBASE from 2000 to March 2023. Data analysis using Excel 2010 (Microsoft Corp) and MedCalc version 20.218. There were 14 studies: 4 randomised controlled trials (RCT), 9 prospective, and 1 cross-sectional. The average improvement in UAS and TSS scores at the end of therapy was 42.24% and 41.24%. Results of subgroup analysis of AST administration in the group autologous serum skin test (ASST) positive and ASST negative based on the end of therapy UAS score (p=0.18). Results of subgroup analysis of AST administration in the positive ASST and negative ASST groups based on the TSS score at the end of therapy (p=<0.001). Results of subgroup analysis of AST administration versus placebo based on TSS score (p=0.861). Based on subgroup analysis, autologous serum therapy improves TSS scores in CSU patients (ASST positive). However, AST is not significantly different from placebo.