bluuebunny/crossref_metadata_2025 huggingface dataset:
Case report of pediatric triple infection: Brucellosis, leptospirosis, and infective mononucleosis in Georgia
Authors: Khurtsilava Ia , Tsirdava Natia , Kanjaradze Darejan , Parulava Tistsino
Published: January 2024

Zoonotic infections are rare in the pediatric population of Georgia. We report a case of co-existing infections with brucellosis, leptospirosis, and infectious mononucleosis in a pediatric patient. An 11-year-old girl presented to our facility with a 12-day history of fever, chills, fatigue, arthralgia, myalgia, and refusal to walk. On evaluation, she was febrile and tachycardic, with hepatosplenomegaly and lymphadenopathy. The patient responded well to combination therapy of doxycycline and gentamicin, had a full recovery and was doing well with no relapse for 2 months follow-up.
Aeromonas septicaemia - A case series
Authors: Babu Aishwarya , Kumar Mahadevan , Mane Abhijeet , Bhatawadekar Sunita Mangesh , Yadav Lata
Published: January 2024

are ubiquitous Gram-negative bacilli which are seen in brackish or fresh water and soil in subtropical or temperate countries. They were considered as pathogen of many animals including fish but recently they have been gaining importance due to its ability to infect and colonise in human body. Though the most common site of infection is gastrointestinal tract, it can cause extraintestinal infections like skin and soft tissue infections, urinary tract infections, biliary tract infections and bacteremia. Its ability to acquire antibiotic resistance naturally from the environment and due to the inappropriate use of antibiotics makes treatment of this unusual pathogen difficult. Many studies have shown high morbidity and mortality rates associated with . Therefore, though it was initially considered as a rare cause of bacteremia, should be considered as an important nosocomial pathogen.
Comparison of Clonidine versus Esmolol in Controlled Hypotension in Patients Undergoing FESS Surgery
Authors: Garg Komal , Nanda Samridhi , Bafna Usha , Mali Chandan Bala , Naaz Sumaila , Sabu Nelwin Jerald
Published: January 2024

Background: FESS has its share of complications which can be a challenge for both the surgeon as well the anesthetist and achieving a bloodless surgical field is essential So the principle of controlled hypotension can be used to combat this issue.
Methods: A hospital-based randomized comparative interventional study was conducted on 60 patients to compare Clonidine (2mcg/kg in 10 ml of saline over 10 minutes before induction followed by an infusion of 1mcg/kg/hr during maintenance) and Esmolol (1mg/kg in 10 ml of saline over 10 minutes before induction followed by an infusion of 1mg/kg/hr during maintenance) to assess and compare the hypotensive properties of both the drugs.
Results: After the induction of anesthesia, there was a significant difference in the mean heart rate, and mean arterial pressure between the two groups throughout the intraoperative period (p-value < 0.05). Both groups achieved a target mean arterial pressure (MAP) of 65-70 mmHg and improved surgical field quality.
Conclusion: This study concluded that clonidine and esmolol both provide hemodynamic stability and a better surgical field in functional endoscopic sinus surgery (FESS). Clonidine also helps in achieving postoperative sedation and analgesia.
Correlation of Ultrasound Guided Inferior Vena Cava Collapsibility Index with Central Venous Pressure to Assess the Volume Status in Postoperative Intensive Care Unit Patients: A Prospective Observational Study
Authors: Surendran Anjane Sree , Kaur Ranvinder , Yadav Rupesh
Published: January 2024

Background: Accurate assessment of intravascular volume status is a vital aspect of management of intensive care unit (ICU) patients. Inferior vena cava (IVC) diameter and IVC collapsibility index have surfaced as promising methods to accurately predict hypovolemia. But no such study has evaluated it’s their utility in postoperative patients.
Methods: The study aimed to assess the correlation between ultrasound guided IVC collapsibility index (IVC CI) and CVP for volume status in intensive care unit patients. Hundred spontaneously breathing patients receiving postoperative care in our surgical ICU between November 2019 to march 2021were enrolled into the study. Maximum IVC diameter (IVCdmax) at end-expiration, minimum IVC diameter at end-inspiration (IVCdmin) and IVC CI were measured. Simultaneous CVP recordings were obtained.
Results: A positive correlation was noted between IVC maximum diameter and CVP (p = <0.001) and between IVC Minimum Diameter and CVP. (p = <0.001) A negative correlation between IVC CI and CVP was seen (p = <0.001). Mean IVC CI was highest in the hypovolemic group. The area under the ROC curve (AUROC) for IVC CI predicting hypovolemia was 0.943 (95% CI: 0.9 - 0.986), thus demonstrating excellent diagnostic performance. At a cut off of ≥58.416%, IVC CI predicts hypovolemia with a sensitivity of 93.8%, and a specificity of 84%.
Conclusion: IVC CI can be used to guide fluid therapy due to its excellent diagnostic accuracy in predicting hypovolemia in postoperative patients in ICU.
Evaluation of Ultrasonography with Conventional Clinical Parameters for Predicting Difficult Laryngoscopy
Authors: Nair Priya S , Mulimani Sridevi , Mantur Jyoti , Suntan Anusha
Published: January 2024

Background: Unanticipated difficult intubation poses a challenge in routine practice for anaesthesiologists. A preoperative airway evaluation helps in the identification of a difficult airway. Airway assessment with ultrasound is a modality recently being used to predict difficult airway. In this study we evaluate ultrasonography parameters with conventional clinical parameters for predicting difficult airway in adults undergoing elective surgeries.
Methods: This cross sectional randomised clinical trial analyses ASA class 1 and 2 adults requiring endotracheal intubation for surgeries under general anaesthesia were enrolled following which Modified Mallampatti score and thyromental distance as well as ultrasound distance to epiglottis (DSE) and distance to hyoid bone (DSHB) were measured and based on Cormack Lehane grading they were categorised into easy and difficult airway groups.
Results: DSE had the highest sensitivity of 90.48% whereas Modified Mallampatti grading had least sensitivity of 66.67%.
Conclusion: The results of this study showed that ultrasonographic measurements at the thyrohyoid and hyoid level have higher sensitivity and specificity than the clinical parameters for airway assessment.
Intranasal Dexmedetomidine as Adjuvant to Local Anaesthetic in Preparation of Nasal Passage for Functional Endoscopic Sinus Surgery: Randomized Controlled Trial
Authors: Kale Jyoti Vishnu , Panse Neha Amey , Gangathade Priyanka , Shete Aniket
Published: January 2024

Background: Intraoperative stress response and ongoing bleeding at surgical site especially in areas like head and neck can cause serious adverse reactions and affect the postoperative outcome. This study compared the effect of intranasally administered dexmedetomidine (dexmed) in combination with local anesthesia (LA) and local anesthetic alone on quality of surgical field, surgical bleeding and haemodyanamic parameters during functional endoscopic sinus surgery (FESS).
Methods: Roller gauge strips dipped in dexmedetomidine were used for nasal packing. Sixty patients undergoing FESS were randomly allocated to receive either intranasal Dexmedetomidine with LA (D group) or intranasal LA alone (L group) via nasal packing 15 min before surgery. The primary objective was to study the quality view of surgical field through the endoscope and the blood loss that occurred while raising the nasal mucosal flap. The secondary objective was to study the intraoperative hemodynamic profile and anesthetic and analgesic requirement during surgery.
Results: Surgical field quality, Blood loss, hemodynamic profile and satisfaction scores of patients and surgeons were significantly better (P< 0.05) in dexmed group.
Conclusion: Patients receiving intranasal dexmed with LA for FESS had better surgical field, surgeon’s satisfaction and minimal hemodynamic fluctuations with lesser blood loss as well as better postoperative comfort and analgesia.
Comparison Between Dexamethasone Versus Clonidine as Adjuvants to 0.75% Ropivacaine in Ultrasound Guided Brachial Plexus Block for Upper Limb Orthopedic Surgeries: A Randomized Prospective Clinical Study
Authors: Balakrishnaiah Mahima K , Sheshadri Karthik G , Ramegowda Sudheer , Srinivasan Rahul , Lolakrishna Raghavendra Ullas , Sambandam Monisha T
Published: January 2024

Background: Ropivacaine is an amino-amide local anesthetic, extensively used for peripheral nerve blocks, numerous adjuvants have been added to Ropivacaine to prolong the duration of analgesia. Aim: To compare the effectiveness of adding Dexamethasone to Ropivacaine versus adding Clonidine to Ropivacaine in ultrasound guided supraclavicular brachial plexus block in terms of analgesic duration, onset & duration of sensory and motor blockade.
Methods: A prospective randomized single blinded study carried out in 70 patients of ASA grade I and II, aged 20 to 60 years scheduled for elective upper limb orthopedic surgeries. Patients were randomly allocated into two groups, Group RC - patients received 20ml of 0.75% ropivacaine along with 1mcg/kg of clonidine diluted to 2ml of normal saline, Group RD - patients received 20ml of 0.75% ropivacaine along with 8mg of dexamethasone (2ml). Statistical Analysis: Onset & duration of sensorimotor blockade, duration of analgesia was assessed by Unpaired t-test. If p-value <0.05, results were statistically significant & p-value <0.001 were highly significant.
Results: Duration of analgesia is superior and statistically significant in Group RD (1,172.57± 18.37 vs 931.09± 16.3). Onset time for sensory (3.14 ± 1.00 vs 9.71± 1.23) and motor (7.60 ± 1.54 vs 13.66± 1.03) block is rapid in Group RD. Duration of sensory (1,106.57± 20.28 vs 786.26± 31.43) and motor (997.74 ± 24.9 vs 674.57 ± 2.18) block is enhanced in Group RD.
Conclusion: Dexamethasone as an adjuvant to ropivacaine provided superior post-operative analgesia, faster onset and longer duration of sensory and motor blockade.
Development and Psychometrics of Safe Anesthesia Evaluation. Three-Step Checklist (Pre-Induction of Anesthesia, Maintenance of Anesthesia, Post-Anesthesia): A Cross Sectional Study
Authors: Babajani Alireza , Moradimajd Parisa , Saei Azam , Abolghasemi Jamile
Published: January 2024

Background: Patient safety is one of the main elements of the quality of health services. Our aim of this study was to compile a complete checklist for the three stages of anesthesia.
Methods: This research was a cross-sectional descriptive-analytical study. First, an internet search was conducted in databases to identify checklists related to safe Anesthesia. The WHO Safe Anesthesia Checklist was designated as the main checklist. Then, a brainstorming session was held with experts and according to the determined fields, the initial draft was compiled. Face and content validity were conducted. The reliability of the checklist was measured with Cronbach's alpha and intra class correlation index (ICC) methods.
Results: The initial draft was compiled with 34 items. 29 items scored higher than 0.79 in terms of CVI (content validity index) The value of CVI of 5 items was less than the permissible limit and the edge of the border, which was revised and corrected by the research group. 2 items were returned to the research process according to the survey of experts and their necessity CVR (content validity ratio) (value >0/62) and 3 items were removed from the research process. Cronbach's alpha was calculated as 0.876 for the first evaluator and 0.870 for the second evaluator, and the percentage of agreement between the evaluators was 0.956 (P<0.001).
Conclusion: We developed and evaluated a checklist for the three stages of anesthesia through an evidence-based study. We hope   this checklist can reduce and prevent clinical errors.
Comparison of Time Taken for Intubation (TTI) in Conventional Laryngoscope with Video Laryngoscope for Endotracheal Intubation In Laproscopic Surgeries
Authors: Pillai Lakshmi S , Mulimani Sridevi , Suntan Anusha , Dandoti Deepa S
Published: January 2024

Background: Direct laryngoscopy necessitates the alignment of the oropharyngeal-laryngeal axis whereas video laryngoscope is an optical vision which doesn’t require alignment. This study aimed to compare direct laryngoscopy with a Macintosh blade to King-Vision Video laryngoscope for endotracheal intubation in patients who were scheduled for elective laproscopic surgeries under general anaesthesia.
Methods: In this prospective randomised clinical study,118 adults with ASA I and II requiring endotracheal intubation for laproscopic surgeries under general anaesthesia were enrolled and randomised into either of the two groups by envelope method, Group DL-direct laryngoscope and Group VL-video laryngoscope where they were intubated using direct laryngoscope with Macintosh blade or King Vision videolaryngoscope. The Primary objective was to compare Time to intubate(TTI), Visualization of the laryngeal view by Cormack-Lehane grade and Successful first attempt. Secondary objective was to record the Number of intubation failure, Number of attempts, Change of anaesthesiologist and use of adjunct equipment and the complications such as oropharyngeal trauma, neck pain, dysphagia and hoarseness.
Results: In comparison to group DL (21.67±4.318s), group VL took longer time to intubate (26.21± 4.150s) but had superior glottic vision than DL group(p=0.0177). Compared to DL group (72.4%), the VL (84.5%) patients had their first successful attempt, inspite of 2 failures. Complications such as pharyngeal pain (8.6%vs29.3%), hoarseness (5.2%vs29.3%), Use of adjunct equipment like bougie (19%vs 3.4%) were significantly higher in DL compared to VL group, while oropharyngeal injury, dysphagia, number of attempts and change of anaesthetists were similar in both groups.
Conclusion: In comparison to the Macintosh laryngoscope, the King-vision VideoLaryngoscope took longer to intubate but had clearer glottis visualisation and a higher first-time success rate and can be used as a good teaching tool. In King-vision video laryngoscope, there was less use of auxiliary equipment and fewer complications.
Relationship between Misconduct of Medical Professionalism with Burnout Syndrome and Related Factors
Authors: Samadi Shahram , Montaseri Alireza , Mireskandari Seyed Mohamad , Shahvari Zahra , Jafarzadeh Afshin , Khan Zahid Hussain , Bafrani Melika Arab
Published: January 2024

Background: Burnout syndrome (BOS) is a common occupational disease amongst medical physicians; especially anesthesiologists. BOS is known to result in increased expenditure of the healthcare system and decreased patient satisfaction. In order to substitute for good conduct by its medical staff, Tehran University of Medical University established its own guidelines on professionalism as a substitute for professional conduct amongst its personnel. Learning and practicing professionalism is not only a requirement to be competent as a specialist, but also it results in increasing healthcare quality and patient satisfaction. There is a lack of studies on the relationship between BOS and professionalism.
Determination of the relationships between professionalism and BOS among TUMS anesthesiology residents.
Methods: In this cross-sectional study all anesthesiology residents completed three forms (demographic checklist, Maslach Burnout Inventory (MBI), and professionalism self-conduct). The results were primarily analyzed using STATA 14.0 and relationships were established via linear and binary regression.
Results: About 44 percent of residents met criteria for BOS. The risk of developing BOS was significantly higher for residents who adhered to the principles of respect and altruism and for residents training in one of our surveyed hospitals; whereas the risk of developing BOS would be reduced by increasing age and adherence to the principles of justice Burnout subscales scores concerning emotional exhaustion and personal accomplishment were significantly related with higher self-reported scores of altruism and honesty-integrity respectively.
Conclusion: The chances of developing BOS could be enhanced by inadequate practice in the field of professional ethics. Therefor the importance of learning and competent practice of professionalism must be acknowledged. Age and professional climate were the most important demographic variables related to BOS in anesthesiology residents
Anesthesia Management in an Edentulous Patient with Huge Parotid Tumour: Case Report
Authors: Munivenkatappa Manjunatha S , Kondi Sudha Rani , Bhaskar Bhaskar , Parvathamma Dayanand V
Published: January 2024

Huge head and neck tumors are known to cause difficult ventilation and difficult intubation. Edentulous mouth can result in difficult mask ventilation. Head and neck tumor resections can also present hemodynamic challenge, due to their proximity to large vessels.
We herein report a clinical case of difficult ventilation due to large parotid tumor in an edentulous patient.
Video Laryngoscopes: A Boon for Parapharyngeal Tumors of Childhood
Authors: Mahajan Man Bhavan , Sharma Mamta , Mahajan Rupali
Published: January 2024

Parapharyngeal tumors often distort the airway anatomy leading to obstruction and hinderance for intubation thus posing a challenge for the anesthetist at securing airway with least damage to the nearby structures.
We present our experience through a series of 5 such cases in children managed successfully using video laryngoscope.
Working in places where availability of advanced airway equipment such as pediatric size fiberoptic is unavailable, a video laryngoscope can help to appropriately assess the airway and prevent disastrous outcomes.
Telemedicine is a Challenging Need for Anesthesiology
Authors: Poor Zamany Nejat Kermany Mahtab
Published: January 2024

The Article Abstract is not available.
Monitoring the Aspects of Financial Risk Protection regarding Universal Health Coverage
Authors: John Anugraha , Teja Avirneni Hari , Sarathamani Swaminathan Sinthu
Published: January 2024

The Article Abstract is not available.
Evaluating of Antioxidant and Antibacterial Characteristics Ginkgo Biloba Leaves
Authors: Barazesh Elina , Govahi Mostafa , Ranjbar Mojtaba
Published: January 2024

Introduction: Reactive oxygen species cause disease by damaging the chemical compounds in our body. On the other hand, drug resistance is becoming a serious issue in infection treatment, globally. Ginkgo biloba has many therapeutically features. The objective of this study was to evaluate antioxidant and antibacterial activity of Iranian Ginkgo’s leaf extracts.
Methods: In this experimental study, aqueous, ethanolic (%70) and methanolic (%80) extracts were made using Ginkgo. Total Phenolic and Flavonoids Content were measured by folin– ciocalteu reagent and Chloride Aluminum color assays. The extracts’ antioxidant activity was assessed by their potential in scavenging DPPH free radicals. Disc Diffusion assay was carried out to test antibacterial potency against two strains of bacteria (Enterococcus faecalis, Listeria monocytogenes). Data analysis was performed using factorial experiment within a completely randomized design. SPSS version 16 software and Duncan's multiple range tests were used to compare the means.
Results: Based on results, all three extracts contained extensive amount of phenolic and especially flavonoid compounds with methanolic extract being the richest in phenolic and flavonoids while aqueous extract having the least of these compounds. The most antioxidant activity was found in methanolic extract of 300 mg/mL concentration with %84.73 (P<0.05) and the least was in aqueous extract of 40 mg/mL with %18.17 (P<0.05) ROS scavenging rate, this result was proportional to the measured bioactive components of the extracts. Antibacterial activity in 200 mg/mL concentration of methanolic extract was maximum against Enterococcus faecalis while it was minimum at 50 mg/µl concentration of aqueous extract against Listeria monocytogenes strain. Antibacterial activity of all three extracts was found out to be concentration dependent.
Conclusion: The results indicated that Ginkgo leaves are rich in phenolic and flavonoids contents that may be reason behind their notable antioxidant and antibacterial activity. Thus, Ginkgo could be a treasure trove of antioxidants and therapeutic compounds. However, more studies are required in regard to Ginkgo’s various characteristics.
Relationship between Mother-Fetus Attachment and Parenting Stress
Authors: Doroudgar Fariba , Pirhadi Masoume , Bakrani Zahra , Torabi Fatemeh
Published: January 2024

Introduction: Attachment is a stable emotional connection between mother and fetus, which is a unique phenomenon. The purpose of this research was to determine the relationship between mother-fetus attachment and parenting stress.
Methods: In this descriptive-analytical study, 250 pregnant women, referred to comprehensive health centers of Borujen University of Medical Sciences, were studied. Data were collected using fertility demographic questionnaires, standard Cranley questionnaire and standard parenting stress questionnaire; data using descriptive statistics, calculating Pearson's correlation coefficient and Spearman's correlation coefficient, independent t test, multivariate regression and analysis of variance test were analyzed.
Results: There was a significant inverse relationship between the total score of parental stress and the total score of mother-fetal attachment and its dimensions (P<0.001). Multivariate regression indicated that the two dimensions of self-sacrifice and mother-fetus differentiation were the most predictors of parental stress. In addition, Pearson's correlation coefficient suggested that the total parental stress score had no significant relationship with demographic and fertility variables (P>0.05). The total mother-fetus attachment score had no significant relationship with demographic and fertility variables (P>0.05) and only had an inverse relationship with the number of pregnancies (P<0.05).
Conclusion: The findings of the research show that by increasing attachment and reducing parental stress, we can witness more parental responsibility towards the infant, thus we can expect to be accompanied by better emotional, care and health support.
Frequency of Coronary Anomalies and Association with Atherosclerotic Coronary Stenoses in the Coronary Angiography Candidates
Authors: Amirzadegan Alireza , Aghajani Hassan , Barkhordari Khosro , Mehrani Mehdi , Ahmadi Aylar , Hedayatpour Azim , Sadeghian Mohammad
Published: January 2024

Introduction: Due to the importance of atherosclerotic changes in the patients with coronary anomalies, it was aimed to evaluate the prevalence of atherosclerotic changes in patients with coronary anomalies who underwent coronary angiography at Tehran Heart Center within two years.
Methods: In this cross-sectional study, all the patients who underwent coronary angiography and were diagnosed with coronary artery anomalies were included in this study (2018-2020). The frequency and frequency percentage of the detected anomalies, cardiovascular risk factors and also the presence of coronary stenosis among the patients were then determined and reported.
Results: Among 79 patients with coronary artery anomaly evaluated in this study, 43 (54.4%) and 36 (45.6) were male and female, respectively. Of these, 39.2% were smokers and 10.1% had an addiction to opioids. The most frequent baseline disease in these patients was dyslipidemia, hypertension, and diabetes mellitus with 63%, 49%, and 46%, respectively. Moreover, hypertension was more frequent in women (p=0.005). A total of 81.6% of the patients (all of them had abnormal coronary arteries) had atherosclerotic stenosis in their coronary arteries. The highest frequency of coronary abnormality was left circumflex from right coronary sinus with 29.1%; the others included absent left main, coronary fistula, and right coronary artery from left coronary sinus, which were 12.7%.
Conclusion: In the patients with coronary artery anomalies, atherosclerotic changes were frequent prevalence, which can be an important cause of sudden cardiac death in these patients.
Comparative Evaluation of Mast Cells in Lichen Planus and Oral Lichenoid Reaction with Giemsa Staining
Authors: Jafari Najmeh , Mahmoudi Seyed Mostafa , Lajevardi Mohamad Bagher
Published: January 2024

Introduction: Lichen planus is a relatively common and chronic mucocutaneous disease with unknown. Oral lichenoid reaction is clinical and histopathological similar to lichen planus, but the cause of it is different. Mast cells are responsible for the accumulation of inflammatory cells in the connective tissue. The aim of study was evaluation of the role of mast cells in pathogenesis of two groups of lesions.
Methods: This cross-sectional study was performed on 26 samples of oral lichen planus, oral lichenoid reaction lesions and 5 samples of irritation fibroma. After the staining with the Giemsa, sections were observed under the optical microscope (x400), and the number of mast cells was counted. The results were analyzed using the SPSS16 software, T test, Mann- Whitney and Chi-squared statistical tests.
Results: The total number of mast cells and degranulated mast cells in two groups were significantly higher than the control group (P<0/05). Nevertheless, the total number of mast cells, the number of degranulated mast cells and the ratio of degranulated mast cells to the total mast cells had no significant difference between the two groups of lesions. (P> 0/05).
Conclusion: Mast cells play a role in the pathogenesis of lichen planus and lichenoid reaction lesions. The number of degranulated mast cells and the ratio of degranulated to the total mast cells cannot help to differentiate these two groups of lesions. Clinical examinations and proper history and attention to their etiologic factors have a significant role in differentiating them.
Comparison of the Vertical and Horizontal Components of the Ground Reaction Force of Patients with Anterior Cruciate Ligament Reconstruction and Healthy Individuals during Walking
Authors: Payandeh Mostafa , Daneshmandi Hassan
Published: January 2024

Introduction: The aim of this research was to compare the vertical, medial-lateral and anterior-posterior components of ground reaction force after anterior cruciate ligament reconstruction with the healthy individuals during walking.
Methods: This was an analytic cross sectional research. The participants of this research included 46 football and volleyball athletes, who were divided into two groups of individuals with anterior cruciate ligament reconstruction (ACLR) and healthy individuals. A force plate was employed to evaluate the components of the ground reaction force while walking.The data were statistically analysed using independent t test and SPSS version 16 software.
Results: The results related to the vertical component of ground reaction force showed that the participants with anterior cruciate ligament reconstruction applied more force to the ground during heel strike and toe-off compared to healthy individuals, although the difference between the two groups was not significant (p=0.09 and p=0.35), but this difference was greater during heel strike. Likewise, the results related to the horizontal components of the ground reaction force showed that participants with anterior cruciate ligament reconstruction applied more force to the ground in all horizontal components of the ground reaction force, but the biggest difference between the two groups was in the first 20% of the stance phase and in the posterior (p<0.007) and lateral (p<0.02) directions. This difference between the two groups was significant.
Conclusion: The results of the research showed that the most important difference between the two groups occurred in the first 20% of the stance phase. Although among the 6 measured components, only the posterior (p < 0.007) and medial (p < 0.02) ground force components were significant.
Evaluation of Brain MRI Findings in Patients Referred with Seizures
Authors: Ahmadi Bani Moein , Amel Shahbaz Amir Pasha
Published: January 2024

Introduction: Seizures are one of the common and warning signs of brain diseases, which doctors often use CT-scan or MRI for diagnose. The present study was conducted with the aim of evaluation of brain MRI of the patients referred with seizures in order to determine their brain lesions and involvement.
Methods: The study was carried out using a retrospective cross-sectional descriptive method. All the patients with seizures referred for MRI to the Radiology Department of Shahid Sadoughi Hospital in Yazd City, Iran during 2016-2020 were examined. By referring to the archives of the radiology department, the records and MRI of the patients referred with seizures were extracted. Then, the data were extracted from the Hospital Information System and the patients' files; after that they were analyzed with SPSS version 16.
Results: The present study was conducted on 105 patients with seizures for brain MRI. 48.6% (51 people) of patients were male and 51.4% (54 people) were female. The average age of the patients was 34.17 ± 10.50 years. MRI was normal in 59% of the patients. 16.2% Non-Specific, 6.7% Mass and 4.8% evidence of Encephalomalacia were also reported. The most lesions with 10.5% were related to left frontal lobe and 2.9% were related to right frontal lobe. 99% of seizures were unspecified convulsion and 1% were postprocedural disorder of nervous system. There was no significant relationship between the gender of the patients and their diagnosis (P>0.471).
Conclusion: Wide abnormalities such as mass, edema, encephalomalacia and demyelination are observed in the MRI of the patients with seizures and are often located in the frontal lobe. In general, seizures can cause transient and reversible brain abnormalities in MRI.
Peran Jurnalisme Warga dalam Mendukung Aspirasi Masyarakat (Studi Terhadap Serambinews.com)
Authors: Bustami Bustami , Kholil Syukur , Jufrizal Jufrizal
Published: January 2024

Kemajuan teknologi dan informasi telah berperan besar dalam memajukan masyarakat. Dengan adanya internet, ruang publik yang luas terbentuk melalui media massa. Hal ini telah membuka peluang partisipasi masyarakat secara luas. Perkembangan teknologi media yang cepat dan kemampuannya dalam menggabungkan media-media sebelumnya, secara perlahan namun pasti memengaruhi praktik jurnalisme. Oleh karena itu, lahirlah Citizen journalism atau jurnalisme warga, yang merupakan salah satu bentuk dari jurnalisme yang melibatkan partisipasi masyarakat dalam menyampaikan informasi. Siapapun, tanpa memandang latar belakang pendidikan, memiliki kemampuan untuk merencanakan, menggali, mencari, mengolah, dan melaporkan informasi kepada orang lain dalam berbagai bentuk apapun. Serambinews.com atau aceh.tribunnews.com salah satu media yang sudah membuka kolom partisipasi masyarakan dalam menyuarakan idem gagasan dan pendapat melalui kolom Kupi Beungoh. Penelitian ini menggunakan pendekatan kualitatif, yaitu sebuah metode penelitian yang digunakan untuk menyelidiki kondisi objek secara alamiah, dengan peneliti sebagai instrumen kunci. Hasil penelitian menunjukkan bahwa Serambinews.com atau aceh.tribunnews.com sudah mulai memberikan kesempatan kepada publik atau masyarakat untuk mengisi gagasan, ide dan pendapatnya melalui kolom Kupi Beungoh. Kolom ini merupakan salah saru kolom yang diberikan kepada siapapun untuk mengisinya, dengan catatan segala tulisan menjadi tanggung jawab pribadi penulis. Oleh karena itu, kolom ini disebut dengan Jurnalisme warga. Hasil penelitian menunjukkan bahwa masih kurangnya minat masyarakat dalam menulis ide dan gagasannya melalui kolom Kupi Beungoh Serambinews.com atau aceh.tribunnews.com. Kolom ini juga memiliki kelemahan dan kekurangam, karena tidak banyak masyarakat yang tahu bahwa kolom ini bagian dari jurnalisme warga.
Analisis Framing Pemberitaan Kasus Obstruction of Justice Ferdy Sambo dalam Media Online Asing
Authors: Al Fatah Muhammad Ghozy , Irfanuddin Fahmi
Published: January 2024

Penelitian ini bertujuan untuk mengungkap atau mengetahui frame yang dibangun oleh media asing terhadap pemberitaan kasus Obstruction of Justice yang melibatkan Irjen Ferdy Sambo serta bagaimana frame tersebut dibangun, menggunakan teknik analisis Robert N. Entman. Media sebagai the fourth estate memiliki pengaruh yang besar dalam membangun persepsi publik atas suatu peristiwa. Semakin berkembangnya teknologi informasi tentu memperbesar kemungkinan atas terbentuknya opini publik melalui media berbasis digital yang dari memiliki tingkat fleksibilitas dan aksesibilitas yang lebih besar dari media konvensional. Kasus Obstruction of Justice menjadi penting diteliti mengingat populernya kasus ini selama beberapa bulan lamanya serta bagaimana kasus ini menjadi gambaran akan penegakan keadilan di Indonesia. Penelitian ini menggunakan pendekatan kualitatif deskriptif serta mengacu pada teknik analisis framing yang dirumuskan oleh Robert Entman dengan berfokus kepada empat aspek analisis untuk dapat mengungkap frame yang dibangun oleh suatu media. Temuan penelitian berupa frame yang dibangun oleh media online asing berupa narasi Polri sebagai institusi bermasalah secara internal maupun eksternal dan kasus Obstruction of Justice serta sederet permasalahan yang menyertainya, merupakan buah dari permasalahan di tubuh Polri. Dalam hal ini media online asing menonjolkan isu budaya impunitas (culture of impunity) sebagai penyebab terhalangnya penegakan hukum di Indonesia yang terkesan tajam ke atas namun tumpul ke bawah.

Kata kunci: Analisis Framing, Obstruction of Justice, Ferdy Sambo, Media Online Asing
Dos sacerdotisas beocias, una de la diosa Deméter, otra de Isis, vinculadas a Dioniso
Authors: Calderón Sánchez Macarena
Published: January 2024

Los objetivos del presente artículo son estudiar en mayor profundidad el papel de dos sacerdotisas griegas antiguas de la región de Beocia y arrojar luz sobre la relación de estas mujeres no solo con las diosas a las que honraban, sino también con Dioniso, divinidad versátil y aglutinante, protagonista endicha región. Las siguientes líneas pretenden formar parte de un estudio más amplio sobre las sacerdotisas de Dioniso (o sacerdotisas de otras divinidadesrelacionadas con este dios) en la antigua Grecia, un tema cuyos estudios son mínimos. Cabe decir que el análisis se ha centrado en el término griego ἱέρειαy un derivado (la denominación genérica de “sacerdotisa” en la Grecia antigua que se otorgaba a las mujeres que ejercían el sacerdocio en cultos cívicos) que encontramos en textos epigráficos. Es necesario destacar la importancia de las fuentes epigráficas, ya que en ámbito religioso aportan datos sobre figuras reales o personajes históricamente constatables que participaron en el culto de las divinidades, frente a las fuentes literarias, que muchas veces se detienen en aspectos anecdóticos.
Νόμος-φύσις en el diálogo entre Jerjes y Demarato (Hdt. 7.101-104)
Authors: Barrionuevo Sergio Javier
Published: January 2024

El presente artículo analiza el diálogo entre Jerjes y Demarato en el libro VII de las Historias de Heródoto. Este diálogo presenta un argumento en defensa de la supremacía del nómos. Por esta razón, muchos especialistas consideran este pasaje como un eco de la discusión en torno a la antítesis nómosphýsis, donde la defensa de una supremacía del nómos puede leerse en clave de “influencia” del pensamiento político de Protágoras de Abdera. En este trabajo se analizará este pasaje con el objetivo de mostrar que el discurso herodoteo opera como “acto de intervención intelectual” en el marco del debate νόμος- φύσις desarrollado en el siglo V a. C. Sin embargo, no se lee esta intervención en clave de una relación de “influencia” sino como una recepción del debate φύσις-νόμος, en la que Heródoto se posiciona de manera antagónica con respecto a Protágoras.
La defensa del fraile Juan Zapata y Sandoval
Authors: López Cruz Paula
Published: January 2024

En la época en la que la Corona española consolidaba su presencia en tierras americanas a través del envío de funcionarios reales, el fraile Juan Zapata y Sandoval, perteneciente a la élite novohispana, defiende, en su tratado Sobre justicia distributiva, que los nacidos en el Nuevo Mundo deben ser elegidos para desempeñar los beneficios eclesiásticos y los oficios seculares de sus repúblicas, por considerarlos candidatos dignos y con los méritos suficientes. Elobjetivo de este artículo es analizar su postura al respecto, en el apartado “Acerca de la distribución de los oficios seculares” del mismo tratado, para mostrar que, en realidad, Zapata no pudo sostener su defensa a favor de los nacidos en el Nuevo Mundo.
El comentario de Bartolomé Melgarejo a las Sátiras de Persio: algunos ejemplos
Authors: Del Amo Lozano Milagros
Published: January 2024

Este artículo pretende dar a conocer la obra sobre Persio que fue realizada en México por Bartolomé Melgarejo, profesor del primer Claustro de la Universidad de México. Se muestran algunos ejemplos de los comentarios con los que completa su traducción de las Sátiras a nuestra lengua; en ellos se aprecian enseñanzas morales que se desprenden de lo que expone el poeta, muy útiles para la sociedad del siglo XVI.
Clinico-economic analysis of COVID-19 etiotropic pharmacotherapy
Authors: Petrov Vladimir I. , Ryazanova Anastasia Yu. , Tokareva Natalia S.
Published: January 2024

Nowadays it is possible to use several drugs of etiotropic therapy with different mechanisms of action and different costs for the treatment of COVID-19. Purpose was to study the costs of antiviral drugs in the infectious hospital of the Volgograd region and perform cost-minimization analyse of one course of antiviral therapy. Materials and methods. ABC analysis was carried out on the basis of reporting and accounting documentation for the issuance of drugs for 2020–2022. Ihe prices of the State Register of Maximum Selling Prices were used in cost-minimization analyse. Results. In 2020, 2021 and 2022 6; 2,7 and 10,6 % of the total costs for drugs, respectively, were spent on antiviral drugs. Among such drugs as favipiravir, molnupiravir, nirmatrelvir/ritonavir and remdesivir, molnupiravir of some manufacturers had the lowest cost of 1 course of therapy, and remdesivir had the highest cost.
Synthesis of new heterocyclic derivatives (benzodioxane-2-yl)methanol and their effect on rat intraocular pressure
Authors: Ozerov Alexander A. , Naumenko Lyudmila V. , Taran Alyona S. , Yakovlev Dmitry S. , Chebanko Alina M. , Pshenichnikova Maria S. , Shcherbakova Nadezhda M. , Solodunova Galina N. , Merezhkina Daria V. , Spasov Александр A.
Published: January 2024

Objective: Synthesis of new compounds, melatonin isosters, and study of their ability to reduce intraocular pressure.

Materials and methods: Based on the previously made forecast and on the similarity with the selected compounds, the synthesis of new compounds was carried out – melatonin isosters having a 2,3-dihydro-1,4-benzodioxin cycle connected by a linker of various chemical structure with a nitrogen-containing heterocyclic core. The structure of the synthesized compounds was proved by 1H- and 13C- NMR spectroscopy, purity and individuality – by chromatographic methods. Intraocular pressure in laboratory animals was measured using a contact veterinary tonometer Tonovet (Finland). Cytotoxicity was assessed using MTT test on normal rat skin fibroblasts.

Results: Derivatives (benzodioxane-2-yl)methanol reduced the level of IOP in varying degrees of severity. The VMA-22-37 compound showed the greatest activity. With topical application of a 0.4% solution, the compound reduced the intraocular pressure of intact rats by 26.6%, while not affecting the control eye. This compound also has low cytotoxicity.

Conclusion: Derivatives (benzodioxane-2-yl)methanol is promising for the search for compounds capable of reducing increased intraocular pressure.
Pharmacoepidemiology of arterial hypertension in adult population of Donetsk city with COVID-19
Authors: Nalotova Olga S. , Alesinsky Mikhail M. , Nalotov Sergey V. , Serdyuk Elena B. , Nalotova Elena N. , Galaeva Yana Yu.
Published: January 2024

The article presents the “Questionnaire for visitors to pharmacies suffering from hypertension”, which made it possible to identify the antihypertensive pharmacotherapy received by patients, the history of COVID-19, as well as the level of blood pressure before and after COVID-19. The questionnaire survey showed that antihypertensive pharmacotherapy in patients with hypertension living in the city of Donetsk is not effective enough, and the transferred COVID-19 led to a deterioration in blood pressure control. Most patients did not take the necessary measures (visiting a doctor, following his recommendations for changing antihypertensive pharmacotherapy).
Influence of kappa-agonist of opioid receptors compound RU-1205 on the generative function of male rats
Authors: Lifanova Yulia V. , Eliseeva Natalia V. , Spasov Alexander A. , Maltsev Mikhail V. , Lavrova Elena B. , Bugaeva Lyubov I.
Published: January 2024

The effect of a new kappa-opioid agonist benzimidazole derivative (compound RU-1205) on the generative function of outbred male rats was studied after oral administration for 2 months at doses of 5 mg/kg – experimentally proven therapeutic dose (TD) and 500 mg/kg (the highest dose is 100 TD). The absence of a damaging effect of the compound RU-1205 on the motivational sexual behavior of males and the processes of spermatogenesis was established.
Neural network modeling of the dependence of RAGE inhibitory activity of chemical compounds on the energy spectrum of multiple docing
Authors: Vasiliev Pavel M. , Perfiliev Maxim A. , Kochetkov Andrey N.
Published: January 2024

Simple and multiple docking into the RAGE receptor of its known inhibitors have been carried out. For these compounds, the energies of simple docking into the specific binding site and the energy spectra of multiple docking throughout the entire volume of the RAGE receptor were calculated. A model of the dependence of the level of RAGE inhibitory activity of chemical compounds on the energy of their simple docking into the specific binding site has been constructed. A neural network model of the dependence of the level of RAGE inhibitory activity on the energy spectrum of multiple docking of chemical compounds has been formed. It is shown that the accuracy of the neural network model based on multiple docking significantly exceeds the accuracy of the model based on simple docking. The found model is used in the directed search for new compounds with RAGE inhibitory activity, which will become the basis for the creation of innovative drugs for the treatment of complications in diabetes mellitus.
A clinical case of paraneoplastic urtivacy syndrome in acute myeloid leukemia
Authors: Molostvova Alsu F. , Salimova Lilia M.
Published: January 2024

Не теряет свою актуальность проблема дифференциально-диагностического поиска при онкологических заболеваниях. Зачастую первым проявлением опухоли является неспецифическая симптоматика, так называемая паранеоплазия.
Цель исследования. Выявление патогенетической взаимосвязи между опухолевым процессом и паранеоплазией на примере собственного клинического наблюдения. Материал и методы. В статье представлен клинический случай паранеопластической крапивницы, развившейся за 3 месяца до постановки диагноза «Острый миелоидный лейкоз».
Результаты. Представленный клинический случай позволил изучить особенности течения паранеопластических синдромов на примере паранеопластической крапивницы.
Выводы. Знание о патогенетических механизмах развития, особенностях течения паранеопластических синдромов должно помочь клиницисту в ранней диагностике онкологического заболевания и своевременном начале этиологического и патогенетического лечения, направленного на сохранение жизни пациента.
Evaluation of the electromyographic study of masticatory muscles using kinesiotape in patients with bruxism
Authors: Vologina Maria V. , Kiba Ksenia A.
Published: January 2024

In this paper, an analysis of the electromyographic study of masticatory muscles before taping and after the use of kinesiotapes in patients with bruxism was carried out.
Mesenchymal Cystic Hamartoma of the Lung
Authors: Fedotov A. N. , Tuyrin I. Е.
Published: January 2024

Mesenchymal cystic hamartoma, which was first described in 1986, is a very rare pulmonary pathology. To date, a little more than 20 cases have been registered in the literature. The disease usually has an asymptomatic course, but can potentially lead to severe pulmonary bleeding and even death. It has no specific radiological signs, therefore it is necessary to carry out differential diagnosis with other diseases, including malignant neoplasms. We present our own clinical observation of this pathology.
Radiomics in the Diagnosis of Thyroid Nodules
Authors: Tokmacheva A. A. , Vyalkin D. S. , Trots A. A. , Tarakanova E. E. , Davletova Yu. I. , Abdullina E. L. , Stepnadze V. B. , Akhmetova A. I. , Shagieva N. E. , Uskova V. D. , Konovalova V. S. , Magdanova A. R.
Published: January 2024

The thyroid nodules (TNs) are widespread throughout the world: according to the pathological studies, they can be found in 50–60% of adults. Currently, ultrasound, computed tomography, magnetic resonance imaging and radionuclide diagnostics, such as positron emission tomography with computed tomography, are usually used to diagnose TNs in clinic. These techniques are mainly used to diagnose the nodile benignity and malignancy, the degree of invasion into adjacent tissues and metastases to lymph nodes. Thanks to the development of artificial intelligence, machine learning and the improvement of medical imaging equipment, radiomics has become a popular area of research in recent years. It allowes to obtain various quantitative characteristics from medical images, highlighting invisible features and significantly expanding the possibilities of identifying and predicting. Radiomics has a high potential in detecting and predicting TNs. We present the information on the development and workflow of radiomics. The article summarizes the application of various imaging techniques to identify benign and malignant TNs, determine invasiveness and metastases to lymph nodes, as well as some new advances in the field of molecular level and deep learning. The disadvantages of radiomics method are also given as well as prospects for its further development.
Pengaruh PDB per Kapita dan Konsumsi Energi terhadap Emisi GRK di Indonesia
Authors:   BPS Kabupaten Nias Selatan, Nadeak Sarwono Alfian H. , Nasrudin Nasrudin ,   Politeknik Statistika STIS
Published: January 2024

Tujuan dari penelitian ini adalah untuk menganalisis pengaruh PDB per kapita dan konsumsi energi terhadap emisi gas rumah kaca, serta menguji hipotesis Environmental Kuznets Curve (EKC) di Indonesia. Penelitian ini menggunakan dua metode, yaitu Error Correction Mechanism (ECM) dan Autoregressive Distributed Lag (ARDL) dengan pendekatan bound testing. Hasil penelitian menunjukkan bahwa PDB per kapita memiliki pengaruh positif terhadap emisi gas rumah kaca. Konsumsi energi terbarukan memiliki pengaruh negatif terhadap emisi gas rumah kaca, sedangkan konsumsi energi tak terbarukan memiliki pengaruh negatif terhadap emisi gas rumah kaca total, tetapi berpengaruh positif terhadap emisi CO2. Dalam jangka panjang, hipotesis EKC berlaku di Indonesia.