bluuebunny/crossref_metadata_2025 huggingface dataset:
Normalized Isometric Shoulder Strength as a Predictor of Ball Velocity in Youth Baseball Players
Authors: Arnold Amanda J , Thigpen Charles A , Beattie Paul F , Fritz Stacy L , Kissenberth Michael J , Tokish John M , Shanley Ellen
Published: February 2022

BACKGROUND

Despite increased awareness of factors related to athletic performance and injury prevention, youth and adolescent baseball players continue to report injuries at alarming rates. Upper extremity muscle strength is an integral part of physical assessment and injury prevention in baseball players, however minimal data exists in youth populations. Changes in anthropometric measures, inherent in physically developing athletes, have been shown to impact strength measures, however normalization methodology is rarely reported.

PURPOSE

The purposes of this study were to 1) compare the measurement properties of five potential methods for normalizing isometric shoulder strength in a cohort of 9-12 year old male baseball players and 2) examine the relationship between normalized isometric shoulder strength and ball velocity in a cohort of 9-12 year old male baseball players.

STUDY DESIGN

Prospective cohort study (n=159)

METHODS

Baseline and follow up height, weight and bilateral ulnar length measurements were assessed followed by isometric strength in both the dominant and non-dominant shoulders. Strength measures included scapular plane abduction (scaption), external rotation (ER) at 0°, ER and internal rotation (IR) at 90°. Ball velocity was assessed as a measure of throwing performance. Intraclass correlation coefficients (ICC2,1), standard errors of measurement (SEM) and minimal detectable change (MDC95) were calculated for all strength measures. Repeated measures ANOVA were conducted comparing changes in normalized strength using five separate anthropometric measures: weight, height, body mass index, ulnar length and % of non-dominant shoulder strength. Linear regression models were used to examine the relationships between normalized isometric shoulder strength and ball velocity. Statistical significance was set a priori at α=0.05.

RESULTS

Shoulder strength normalized using ulnar length was the only method that demonstrated excellent reliability (ICC2,1 0.98-0.99) and detected significant changes between strength in each of the four measures tested (SEM 0.39-0.69 Nm). Modest but significant correlations were observed between scaption and ball velocity (r2 = 0.27, p < 0.001) and ER at 0° and ball velocity (r2 = 0.23, p < 0.001).

CONCLUSION

Ulnar length was the most stable and reliable normalization method for assessing isometric shoulder strength in youth baseball players. In addition, normalized scaption strength was the most significant predictor of ball velocity, followed by ER at 0° strength in this population.

LEVEL OF EVIDENCE

Level 2b (etiology)
Injury and Injury Prevention in United States Para Swimming: A Mixed-Methods Approach
Authors: Salerno Jay , Tow Stephanie , Regan Elizabeth , Bendziewicz Stephen , McMillan Matthew , Harrington Shana
Published: February 2022

Background

Para swimming has experienced increased participation in recent years. Injury and injury prevention research on Para swimmers is lacking compared to swimmers without impairment.

Purpose

This study aimed to gather data in Para swimmers on typical injuries, injury prevention programs, and attitudes toward injury and injury prevention in this population.

Study Design

Cross-sectional, mixed-methods design evaluating injuries, injury management, and injury prevention in elite Para swimmers in United States (U.S.).

Methods

Para swimmers on the U.S. Paralympics Swimming National teams at multiple competition levels were invited to complete an online survey. Qualitative interviews with six U.S. Paralympics National team Para swimmers were conducted to provide detail on athlete experiences with injury and prevention.

Results

Twenty-one of 56 surveys were returned: 11 of 21 participants (52.4%) reported experiencing an injury that altered their weekly training. All (21/21) reported participating in strength training and 19 of 21 (90.5%) reported incorporating stretching into their training regimen, although strengthening/stretching regimens included routines that may not have been specifically targeted toward injury prevention. Six of 21 (28.6%) reported participation in an injury prevention program. Qualitative interview themes included the impact of swimmers’ compensated body mechanics on injury risk, the value of individualized injury prevention programs, and the importance of knowledgeable coaching and rehabilitation staff.

Conclusions

Injury prevention programs are important components in Para swimming training although they are underutilized based on responses in this study. These programs should be individualized to address swimming biomechanics and athlete-specific impairments. Increasing coaching knowledge and access to individualized programs may reduce injury prevalence among this at-risk population.

Level of Evidence

3
Numerical Study of Wind Loads on Y Plan-Shaped Tall Building Using CFD
Authors: Goyal Pradeep K. , Kumari Sonia , Singh Shivani , Saroj Rahul Kumar , Meena Rahul Kumar , Raj Ritu
Published: February 2022

The increase in the population is at an exponential rate, and the available land is in the form of irregular shapes. That is why irregular shapes are very commonly built. Wind load increases with respect to height, so wind load evolution is necessary for such high-rise structures. Wind forces majorly depend on the plan's cross-sectional shape. Therefore, for an irregular shape, an investigation is needed for tall buildings. This paper demonstrates a detailed study on velocity stream line, external pressure coefficients, pressure distribution on the surfaces of the building and the turbulence kinetic energy for the Y-shaped plan for tall buildings under wind excitation for wind incidence angles of 0o to 180o. k-  turbulence model is utilized to solve the problem using computational fluid dynamics techniques in ANSYS for terrain category II as per IS: 875 (Part3), 2015. Wind ward faces in all building models show positive pressure distribution, while the leeward faces are under the effect of negative pressure distribution. Wind load can be reduced on building models by modifying the corners, such as chamfering, rounding, and double recessed. The variation of pressure distribution on different faces of a "Y" plan shaped tall building for 0° and 180° is investigated using ANSYS CFX, and the pressure contours are plotted for all the faces of different "Y" shaped buildings to compute the effect of corner modification on pressure distribution. In this research, it was found that building models with rounded corners are highly efficient in resisting the wind load. Doi: 10.28991/CEJ-2022-08-02-06 Full Text: PDF
AHP Approach for Determining Category in Social Media Content Creation in Order to Maximize Revenue per Mille (RPM)
Authors: De Guzman Kevin Joseph , Robielos Rex Aurelius C.
Published: February 2022

This study utilizes the Analytic Hierarchy Process (AHP) in the selection of an optimal niche or category of videos for maximizing view count. The main income from videos is derived from RPM, which is a set amount per thousand views. A set of criteria was determined from attributes in the dataset that logically contribute to either the videos’ SEO or trend/popularity. The criteria in question were also determined by commonalities across a vast number of video content platforms, which focus more on the essential attributes of a video. In order to perform pairwise comparison, weights were derived from coefficients generated using Linear Regression. Following the creation of the model, we identify the categories with the highest potential for gaining views. Based on the results, the study may be performed in another time frame to reflect the major shifts in public interest over time. Thus, the importance of its repeatability and degree of usability across datasets from different platforms is emphasized. Doi: 10.28991/HIJ-2022-03-01-07 Full Text: PDF
EVALUATION OF THE EFFICIENCY OF CREATING ECOSYSTEMS ON THE BASIS OF FINANCIAL ORGANIZATIONS WITH SWOT-ANALYSIS
Authors: Inalkaev Aslan
Published: February 2022

The COVID-2019 pandemic acted as a catalyst for new challenges and changes in the financial system of all countries, including Russia. The digital progress of recent years has created significant potential for growth, which during the period of self-isolation and restrictions contributed to the expansion of the range of services provided remotely, which ensured a significant increase in the client base for those companies that were able to provide their services remotely, ensured their effective presence in the digital space and expanded the product range without additional costs. The article analyzes the prospects for development of financial ecosystems in the domestic market, as well as assesses the opportunities and threats of this process, taking into account the specifics of the formation of ecosystems, the core of which is mainly large financial organizations in our country.
El estado del arte y el marco teórico en la investigación: una base para el desarrollo de trabajos de grado
Authors: Alzate Ibáñez Angélica María , López Niño Desiderio
Published: February 2022

Uno de los objetivos de este texto es resaltar la investigación como garantía de la calidad académica. Su lectura nos permite observar la estrecha interrelación entre la docencia, la investigación y la extensión social. Hablar de calidad en la educación, considerando que es un servicio inmaterial donde se genera y transmite conocimiento, implica revalorar los métodos de aprendizaje y de enseñanza; que se logre imprimirle dinamismo al currículo, como producto de las investigaciones que adelantan los grupos de investigación uniamericanos, donde el docente comparta saberes actualizados y pertinentes de acuerdo a los requerimientos de la sociedad actual.
Investigating the relationship between point-of-care uric acid and dietary pattern
Authors: Chuk Peter , Kan Carrie
Published: February 2022

Introduction High serum uric acid due to improper dietary intake has been identified to associate with painful gouty attack. This study investigates the relationship between point-of-care testing in uric acid and the dietary pattern among participants attending the 2014 Vegetarian Festival in Hong Kong. Method A cross-sectional study was conducted using questionnaire to collect demographic data and dietary pattern of the participants. Point-of-care analyzer was used to measure their serum uric acid. Data was analyzed by descriptive and non-parametric statistics. Results A total of 94 health seekers participated in the study. A prevalence of high POC-UAs was identified among these participants (14.9% (14/94)); non-vegetarians (18.5% (12/65)) tended to have a higher proportion of high POC-UAs compared to vegetarians (7.1% (2/28)); half of these participants with high POC-UAs had obesity 23.5% (4/17) and 1-3 chronic diseases (53.3% (8/15)). The POC-UAs of those having 1-3 chronic diseases 53.3% (8/15) were also significantly greater than those of a single chronic disease 25.0% (1/4) (Χ²=26.769, p<0.001). Discussion The findings suggested that Point-of-care testing can be an effective predictor of gout risk as most individuals may be unaware of their hyperuricemia condition because of asymptomatic at an early stage. Conclusion For a better control of hyperuricemia and prevention of acute gouty attack, health education with a convenient monitoring using Point-of-care method and dietary intervention is recommended.
Metodologías de la enseñanza-aprendizaje en la educación virtual
Authors: Espinosa-Rodríguez José
Published: February 2022

El aprendizaje es un proceso continuo y diverso que requiere conocimientos y competencias para afrontar la vida y hacerles frente a los retos del siglo XXI, los cuales se agudizaron debido a la emergencia sanitaria derivada por la covid-19. En ese sentido, la implementación de metodologías activas en entornos virtuales de aprendizaje (EVA), son una respuesta para superar los retos presentados en cuanto al desarrollo de aprendizajes significativos en modalidades no presenciales y a la innovación de la práctica pedagógica mediadas por las Tecnologías del Aprendizaje y el Conocimiento (TAC). Entre las metodologías más utilizadas en los EVA se encuentran el método de casos, el aprendizaje basado en problemas, el aprendizaje basado en proyectos y el aula invertida. Adicionalmente, existen técnicas que permiten “activar” momentos de aprendizaje, fomentando la participación, el trabajo colaborativo y la generación de contenidos de los estudiantes, privilegiando así la aplicación por sobre la transmisión de contenidos. Por otro lado, para introducir de forma efectiva las TAC en el proceso de enseñanza–aprendizaje a través de las metodologías activas supone transformar la práctica educativa desde el cambio de roles (docente y estudiantes) y su relación con el dominio digital, a través del desarrollo de competencias digitales. Finalmente, existen una gran cantidad de recursos digitales que pueden ser utilizados como parte de las metodologías activas, cuyo objetivo será superar el rol pasivo de estudiantes y docentes como consumidores de información, permitiéndoles adoptar un rol más activo en la generación de nuevos conocimientos a partir del intercambio con otros usuarios de la web.
Implementation of Ensemble Method in Schizophrenia Identification Based on Microarray Data
Authors: Purba Diya Namira , Fhira Nhita  , Isman Kurniawan
Published: February 2022

Schizophrenia is a chronic mental illness that leads the patient to hallucinations and delusions with a prevalence of 0.4% worldwide. The importance early detection of Schizophrenia is tracking the pre-syndrome of Schizophrenia during the active phase, and could reduce psychosis symptomatic. However, the method sometimes cannot detect the symptoms accurately. As an alternative, machine learning can be implemented on microarray data for early detection. This study aimed to implement three ensemble methods, i.e., Random Forest (RF), Adaptive Boosting (AdaBoost), and Extreme Gradient Boosting (XGBoost) to identify Schizophrenia. Hyperparameter tuning was performed to improve the performance of the models. Based on the results, we found that the model 6, which is developed by the XGBoost method, performs better than other models with the value of accuracy and F1-score are 0.87 and 0.87, respectively.
SYNERGISTIC MECHANISMS OF ACTION: COMPARISON OF ADCC AND SIGNALING PATHWAYS INHIBITION BY TRASTUZUMAB BIOSIMILAR OR ORIGINATOR TRASTUZUMAB IN COMBINATION WITH PERTUZUMAB IN HER2+ BREAST CANCER CELL LINES
Authors: Pimentel Franklin Fernandes , Tiezzi Daniel Guimarães , Andrade Jurandyr Moreira de , Gonçalves João , Cardoso Ana Carolina Ferreira , Castilho Vivienne Carduz , Chammas Roger , Toledo Juliano Simões de
Published: February 2022

Objectives: Trastuzumab and pertuzumab bind to HER2 synergistically at different subdomains, improving the clinical benefit of breast cancer treatment. Recently, trastuzumab biosimilars were approved after comparison with the originator, proving high similarity in structure and activity, and equivalent efficacy, safety, and immunogenicity. This study aimed to compare in vitro antibody-dependent cell-mediated cytotoxicity (ADCC) and HER2-signaling inhibition elicited by biosimilar trastuzumab (BS-TZB) or originator trastuzumab (TZB) in combination with pertuzumab (PTZ). Methodology: Human breast cancer cell lines BT474 (HER2+/estrogen [ER] and progesterone receptor [PR]-positive) and HCC1954 (HER2+/ER and PR-negative) were used. Anti-HER2 antibodies: TZB (Herceptin® 440 mg, Roche, batch: N7194B11-B3064); BS-TZB (Zedora® 440 mg, Libbs/Biocon [trastuzumab-dkst], batch: 18F0072); and PTZ (Perjeta® 420 mg, Roche, batch: H0260B01) were commercially acquired. ADCC assay: cells were incubated with TZB or BS-TZB, with/without PTZ. To determine the cytotoxicity percentage, the LDH activity using the CytoTox-ONETM was measured. Western blot: HCC1954 cells were incubated with TZB or BS-TZB, with/without PTZ to analyze the HER2 signaling cascade. We analyzed that Akt, ERK, STAT3, and MKK3/6 were the downstream molecules. Results: ADCC activity of BS-TZB was higher than that of TZB in both cell lines (EC50 [μg/mL]: 1.01 and 1.32, respectively, for BT474: 0.16 and 0.23, for HCC1954). Combined with PTZ, BS-TZB also showed slightly higher ADCC activity than TZB (EC50 [μg/mL]: 0.90 and 1.15, for BT474: 0.13 and 0.19, for HCC1954). BS-TZB and TZB inhibited the phosphorylation levels of Akt, ERK, STAT3, and MKK3/6 in a dose- dependent manner. PTZ enhanced inhibition effects of BS-TZB and TZB on p-AKT and p-ERK, while it had no effect on the p-STAT3 and p-MKK3/6. Conclusions: In association with pertuzumab, trastuzumab biosimilar showed non-inferior biological potency and equivalent signaling inhibition compared with originator trastuzumab. This study explored mechanisms elicited by dual HER2 blockade, showing the same pattern for BS-TZB as well as TZB, combined with PTZ.
TRIPLE-NEGATIVE BREAST CANCER AND BRCA1 UNDEREXPRESSION ASSOCIATION: AN EVIDENCEBASED META-ANALYSIS OF CASE–CONTROL STUDIES
Authors: Souza Fabiana Lúcia de Lima , Lopes Francielle Souza Silva , Porto Hellen Karine Paes , Costa Cesar Augusto Sam Tiago Vilanova-
Published: February 2022

Objectives: This meta-analysis aims to evaluate the association of triple-negative breast cancer and BRCA1 gene underexpression by means of a meta-analysis. Methodology: Case–control studies, published between the years 2011 and 2015, were selected from three available databases (PubMed, Scopus, and Web of Science) and were analyzed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Literature search was performed using the key words “([triple-negative breast cancer] AND [BRCA1] AND [Associated] AND [expression]).” Study quality was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE). The quality of evidence of the studies was classified into four categories: high, moderate, low, or very low quality. We also analyzed the influence of possible conflicts of interest and any information on ethical approval of the studies. Results: A total of 11 studies, out of the 189 studies initially identified, were included in this meta-analysis after applying the inclusion and exclusion criteria. Results show a high prevalence of BRCA1 mutations and underexpression on triple-negative breast cancer patients (χ2 =33.814 and p=0.0001). Studies also show that chemotherapy remains the basis of systemic treatment for breast cancer patients with the BRCA1 mutations and after triple-negative breast cancer treatment, tumor recurrence and resistance to therapy remain a challenging problem. Conclusion: This meta-analysis corroborates other studies that the underexpressive BRCA1 carriers are linked to a higher risk to develop breast cancers that tend to be negative for estrogen (ER), progesterone (PgR), and HER-2 receptor (triple-negative).
ASSOCIATION BETWEEN PERIODONTAL DISEASE AND BREAST CANCER: SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Vieira René Aloisio da Costa , Pirola William Eduardo , Barroso Eliane Marçon , Gama Ricardo Ribeiro , Santos Neto Martins Fideles dos , Lima Marcos Alves de , Oliveira-Junior Idam de
Published: February 2022

Objective: The present study evaluates a possible association between breast cancer and periodontal disease (PD) as a risk factor. Materials and Methods: Ethics approval 3.462.635. This is a systematic review of the literature combined with a meta-analysis. Five databases were searched, and relevant studies published were retrieved and screened. The articles were evaluated and subsequently synthesized using the PRISMA methodology. Odds ratios (OR) with 95% confidence intervals (CI) to assess the association between PD and the risk of breast cancer were calculated. Results: Initially, 712 were identified, and after abstract analysis, 14 articles were selected for qualitative evaluation, and 11 presented sufficient data for meta-analysis. We selected cohort studies (prospective and retrospective) and case–control studies. Literature reviews, meta-analyses, and clinical case reports were excluded. Regarding 233,215 women, the meta-analysis showed that PD increases the risk of developing breast cancer, OR=1.619, 95%CI 1.544–1.698, and this positive association was present in seven studies. Conclusion: PD increases the risk of breast cancer. Since the quality of the studies was heterogeneous, further studies with improved methods are needed to better quantify the risk.
IMPACT OF PHYSICAL ACTIVITY ON PHYSICAL FITNESS AND BODY COMPOSITION OF WOMEN AFTER BREAST CANCER TREATMENT
Authors: Lara Édipo Giovani França , Esposito Selene Elifio , Rocha José Claudio Casali da
Published: February 2022

Introduction: Much has been discussed about benefits of physical exercise in women who have ended breast cancer treatment, which includes not only the improvement of their quality of life but also a remarkable decreased risk of recurrence. To achieve these benefits, it is important that the parameters for prescribing and monitoring physical activity for this population are well defined, as well as the evaluation of factors that may interfere with the results and the adherence to physical exercises. Objectives: To assess the impact of physical exercise on physical fitness and body composition in women who have ended breast cancer curative treatment and to evaluate the impact of physical exercise on women with binge eating disorder. Methods: This prospective study included 107 women between 18 and 60 years of age shortly after the end of their curative treatment for breast cancer (surgery and/or chemotherapy and/or radiotherapy). The participants, after signing the informed consent form, were motivated to do aerobic exercises, localized muscular strength/resistance, and flexibility exercises. Intervention consisted of sets of physical exercises prescribed to all participants by a physical educator in progressive intensities and volumes over the months, according to their adaptive responses, considering individual capabilities and limitations. All participants were evaluated at entrance for cardiovascular morbidities and oriented how to exercise by their own at their homes. Evaluations including body composition, VO2max, and localized muscle resistance were performed at pre-intervention (basal), after 6 and 9 months of intervention. Results: A total of 78 (72.8%) women adhered to the training program, and 29 (27.2%) chose not to adhere. After 9 months of regular and individualized intervention, adherent women showed significantly better results in all variables of body composition and physical fitness: body mass (-4.38±3.67 kg; p0.05), as well as it was not influenced by breast cancer characteristics (e.g., histology, stage, and molecular subtypes) or treatment (i.e., mastectomy, axillary surgery, chemotherapy, or radiotherapy; p>0.05). Conclusion: Our study shows that individualized programs of self-training sets of physical exercises, remotely guided by a physical education professional, could improve the body composition and physical fitness of women in surveillance after breast cancer, regardless of the history of breast cancer or treatment, showing that it is possible to reduce risk factors associated with breast cancer recurrence and to contribute to a better quality of life for these women.
ICOMBINED SELOL NANOCAPSULES AND MAGNETIC HYPERTHERMIA THERAPIES WITH PEQUÍ OIL SUPPLEMENTATION TO TREAT BREAST TUMOR AND PREVENT METASTASES IN A SHORT-TERM IN AGED SWISS MICE
Authors: Pinheiro Willie Oliveira , Andrade Laise Rodrigues de , Sousa Marcelo Henrique , Santos Mayara Simonelly Costa do , Farias Gabriel Ribeiro , Joanitti Graziella Anselmo
Published: February 2022

Breast cancer is a group of malignancies most common among women. In 2018, approximately 2.1 million women were diagnosed, with 626,679 deaths. The traditional classification of these diseases is based on the extent of illness (in situ or invasive), the affected tissue (epithelial tissue for instance), and the site of occurrence (duct or lobe). The invasive ductal carcinoma is the most common type. The classification based on molecular characteristics divides breast cancer into at least five groups: Luminal A, Luminal B, negative HER-2, positive HER-2, and triple negative, being the most aggressive subtype. The disadvantages presented by traditional treatments have stimulated the search for new therapeutic alternatives in order to decrease the toxic and adverse systemic effects besides increasing the effectiveness of tumor treatment. So, combined therapies using nanostructures, with molecular sizes, such as magnetic nanoparticles (NPMs) for magnetic hyperthermia and PLGA-Selol nanocapsules as chemotherapy associated or not with supplementation of pequí oil, may represent an innovative and promising tool in cancer therapy. Objective: This study aims to evaluate the effectiveness of magnetic hyperthermia using NPMs combined with chemotherapy by Selol nanocapsules associated or not with pequí oil, in the treatment of breast tumors implanted in elderly Swiss female mice. Material and methods: The effectiveness of the treatment was evaluated by clinical, hematological, biochemical, genotoxic, and histopathological parameters. The treatment period was 7 and 14 days. Results: The combined therapies of magnetic hyperthermia and PLGA-Selol nanocapsules prevented metastases to lymph nodes, liver, and lungs, and a case of complete tumor remission was observed. The next step is to evaluate if the supplementation with pequí oil can enhance the efficacy of these treatments. Conclusion: The results already showed the potential use of these therapies for future clinical trials in elderly patients with breast cancer.
HOW MUCH CAN WE TRUST ON THE SELFREPORTED COLOR WHEN EVALUATING BREAST CANCER ANCESTRY
Authors: Vieira René Aloisio da Costa , Silva Débora Sant’Anna de Andrade e , Laus Ana Carolina , Bacchi Carlos Eduardo , Silva René Julias Costa e , Oliveira-Junior Idam de , Pereira Rui , Reis Rui Manuel Vieira
Published: February 2022

Objective: To evaluate the association between self-reported color and ancestry in Brazilian patients with breast cancer (BC). Methods: Ethics approval 1136/2016. This was an observational, transversal, epidemiological study, evaluating 1,215 patients with BC. DNA was extracted to evaluate ancestry. For genetic ancestry, a 46 AIM-INDEL panel was used, and the polymerase chain reaction (PCR) products were subjected to capillary electrophoresis. The ancestral profile was evaluated with Structure v.2.3.3 software, for ancestry proportion, the percentages of ancestry in the different self-referred colors. For this purpose, descriptive statistics was performed (mean ± standard deviation [minimum − maximum]). To assess differences between groups, ANOVA and Bonferroni were used. Results: The color distribution was 77.9% (946) white, 17.4% (212) brown, 4.1% (50) black, 0.3% (4) yellow, and 0.2% (3) mixed. Genetically, the African ancestry proportion was significantly (p <0.001) higher in yellow (0.48 ± 0.51 [0.04–0.93]) with less difference between the other groups. Finally, the Amerindian ancestry proportion frequency was less frequent in all groups, and cafuse patients did not express differences between all race groups. Brown race group presented differences in the African and European Ancestry. Conclusion: Although we found many similarities between white color — European ancestry, black color — African ancestry, and yellow color — Asian ancestry, there is great miscegenation between patients and although they can be labeled as having one color, they do present many ancestral genes that would allow their inclusion in another race group.
PALB2 MUTATION IN A 31-YEAR-OLD WOMAN: A CASE REPORT
Authors: Ó Júlia R. S. do , Fernandes Joaquim F. , Segato Rafael C. E. , Rodrigues Frank L. B. , Lima Ana Cláudia G. , Freitas Nilceana M. A. , Abreu Deidimar C. B. , Oliveira Leandro G.
Published: February 2022

Introduction: Oncogenetics advances allow to identifying the relationship between many genes and breast cancer (BC). The PALB2 (partner and localizer of BRCA2) gene is intimately involved in DNA damage response, and although very rare, heterozygous mutations are highly penetrant for BC. There are not enough studies to define the ideal follow-up and management of the patients with BC. Case Report: A 31-year-old female, G0P0A0, presents complaining of a lump in her right breast with no family history of cancer. A breast ultrasound was performed and revealed BI-RADS3. Core biopsy revealed a grade 3 ductal infiltrate carcinoma, with micropapillary features. Immunohistochemistry testing detected estrogen receptor (100%), progesterone receptor (3%), negative HER2 (−), and Ki67 (proliferation marker) (15%). The patient presented with a breast mass (8 cm × 8 cm), nipple inversion, and clinically was N1. Magnetic resonance imaging of the breast showed right axillary lymph node enlargement of 1.1´1.6 cm, and retroareolar and lateral quadrants of the right breast distortions. Because of diffuse skin thickening and nipple retraction, the disease was classified as cT4N1. She received neoadjuvant chemotherapy (weekly paclitaxel followed by dose-dense doxorubicin and cyclophosphamide) with concomitant ovarian suppression. Genetic testing for ovarian cancer and BC found the pathogenic variant c.2164_2168del, p. (Met723Valfs*21), in heterozygosity in the PALB2 gene and interpreted based on the clinical picture and the classification of variants of the American College of Medical Genetics. A right mastectomy with pathologic complete response in the breast and a micrometastasis node 1.5 mm/10 (ypT0N1mic) was conducted. Prophylactic left adenomastectomy was negative for malignancy. In the adjuvant setting, radiotherapy and endocrine therapy with ovarian suppression and aromatase inhibitor for 5 years were scheduled. Conclusion: The critical role of PALB2 in DNA repair increases the risk for BC and contralateral BCs. There is no evidence of adverse outcomes or toxicity with the use of radiotherapy in PALB2 carriers. Locoregional management and prophylactic decisions should be made on the basis of conventional clinicopathologic factors and international guidelines recommendations.
A rare case of cord compression secondary to extramedullary haematopoiesis from a radiological perspective.
Authors: Tauseef Aman  , Amna Ejaz  , Saad Siddiqui
Published: February 2022

Objective: Extramedullary haematopoiesis is commonly encountered occurrence which can rarely cause acute spinal cord compression secondary to intraspinal extension. We present case of a young gentleman who presented with acute paralysis due to this condition.
Benefícios do uso de lagoa de dejetos em um confinamento em pequena propriedade de atividade leiteira, no município de Douradina-MS
Authors: Gonçalves Thamiris Wolff , Da Costa Érika Cecília Pereira , Oliveira Euclides Reuter , Durães Hellén Felicidade , Silva Janaina Tayna , Neves Nathálie Ferreira , Alves Rosilane Teixeira , Gabriel Andréa Maria de Araújo , Gandra Jefferson Rodrigues , Peixoto Eduardo Lucas Terra , Menegat Alzira Salete , Gonçalves Daniely Pereira
Published: February 2022

O manejo e o armazenamento correto de dejetos (fezes, urinas e águas desperdiçadas dos bebedouros) produzidos pelos bovinos em confinamentos, é uma preocupação dos produtores. Este procedimento, se realizado de forma incorreta, pode acarretar em sérios problemas para o meio ambiente e para os próprios animais. Entretanto, quando o manejo é realizado adequadamente, os dejetos podem trazer muitos benefícios para a propriedade, visto que são fertilizantes que podem ser utilizados nas produções de grãos e volumosos, além de reduzir as infestações de endo e ectoparasitas. Neste contexto, objetivou-se com este trabalho caracterizar uma unidade demonstrativa baseado num levantamento dos benefícios do uso de lagoa para armazenagem de dejetos em uma pequena propriedade leiteira, localizada no município de Douradina – MS. A propriedade possui um confinamento de vacas leiteiras, em três barracões cobertos, contendo uma área com palha de arroz, e outra área de piso de cimento onde se encontram os cochos e bebedouros. As áreas são separadas, de maneira que a cama de palha não tem contato com a parte úmida, no qual os dejetos dos animais são lavados e canalizados até as lagoas através de tubulações. As lagoas possuem em média 20 metros de comprimento, 6 metros de largura e 2 metros de profundidade, obtendo uma capacidade de 240m3, revestidas por uma manta plástica, para evitar contaminação do solo e das águas. A lavagem da área úmida e realizada diariamente para não ocorrer acumulo de dejetos no local. As lagoas são esvaziadas aproximadamente de 20 em 20 dias e os resíduos são destinados a pulverização nas lavouras, servindo como substituto de fertilizantes químicos. O uso da lagoa de dejetos acarretou maior bem estar para estes animais, melhor saneamento ambiental e menor riscos de doenças, não havendo malefícios para o solo. Houve, ainda, maior rentabilidade para o produtor devido ao uso como biofertilizantes, melhorando assim a pastagem e aumentando a produção da mesma. Constatou-se, também, maior economia por parte do produtor beneficiando a produção leiteira. Conclui-se que a utilização das lagoas é uma ótima opção para o produtor, evitando o descarte indevido dos dejetos, preservando assim o solo da propriedade e melhor desenvolvimento na produção leiteira e no crescimento da pastagem.
As decisões do Supremo Tribunal Federal referentes à pandemia do covid-19 e a cooperação entre os entes federados
Authors: Hübner Bruna Henrique , Reck Janriê Rodrigues
Published: February 2022

Este trabalho versa sobre as decisões do Supremo Tribunal Federal referentes à pandemia do COVID-19 e a cooperação entre os entes da federação. O problema que norteia a pesquisa é identificar se nas primeiras decisões do Supremo Tribunal Federal sobre COVID-19 o tribunal estabeleceu ou pelo menos insinuou um dever de cooperação entre os poderes e União, Estados e Municípios. A metodologia que se utiliza para a abordagem é a dedutiva, onde a análise dos casos concretos se dará ao final, após o desenvolvimento do referencial teórico e dos conceitos e categorias fundamentais ao trabalho. O método de procedimento é o monográfico e a técnica de pesquisa a bibliográfica (livros, revistas, artigos, jornais, sites). O trabalho divide-se em dois grandes tópicos, primeiro abordar-se-á o papel dos tribunais constitucionais nas democracias, para depois adentrar nas decisões do Supremo Tribunal Federal. A conclusão é de que o Supremo Tribunal Federal apontou em suas decisões a aplicação de um federalismo descentralizado, baseado na cooperação, em observância à Constituição Federal de 1988 e seu espírito federalista, que prevê competências para cada um dos entes federativos.
Ações de extermínio e capitulação dos mecanismos de proteção das populações indígenas em MS
Authors: Ferreira Mendes Leonardo
Published: February 2022

Este artigo tem por escopo abordar os métodos de extermínio empregados pelo Estado brasileiro contra os povos indígenas do cone-sul do Estado de Mato Grosso do Sul, bem como os mecanismos de proteção de referidos povos. A fim de cumprir tal desiderato, foram relatados alguns dos principais problemas desses povos, como a ausência de demarcação de terras indígenas, ausência de acesso a serviços e bens essenciais mínimos, retirada forçada de crianças do seio de suas comunidades, negativa de contraditório e ampla defesa nos processos judiciais e encarceramento indevido de indígenas. Na sequência foram elencados os principais mecanismos, administrativo e judicial internos e políticos e judiciais internacionais, bem como foi analisado se referidos mecanismos têm sido efetivos na proteção de direitos desses povos tradicionais. Por fim, concluiu-se que existe uma política organizada e sistemática de extermínio dos povos indígenas e que os mecanismos de proteção não vêm atuando de forma efetiva.
“They are almost humans like us”: indigenous politics and policy dismantling under Bolsonaro’s government
Authors: Barros Soares Leonardo , Grant Baines Stephen
Published: February 2022

This paper argues that three ongoing dismantling processes target the Brazilian indigenist policy under Bolsonaro’s government: (1) the dismantling of the land claims recognition policy and institutions; (2) the dismantling of the protection of indigenous lives due to the increasing violence against indigenous peoples and the COVID-19 pandemic; and (3) the dismantling of the integrity of traditional territories related to government plans to open indigenous lands to large-scale agricultural and mining operations. On the other hand, we point out that Brazilian indigenous movements’ contemporary strategies are developing to fight back against the dismantling of indigenist policy. We use primary and secondary data to investigate those topics, discussing them in depth using the policy-dismantling theoretical framework. We conclude by pointing to the fact that the ongoing dismantling may contribute to the genocide of Brazilian indigenous peoples.
Relevant aesthetic choices for dysphoric times in contemporary Brazil
Authors: Moreira Paulo
Published: February 2022

This paper analyzes two films, the fiction feature Bacurau by Juliano Dornelles and Kleber Mendonça Filho and the documentary Democracia em Vertigem by Petra Costa, as well as two essays (“Suspeito que estamos” and “Gente frouxa”) by Nuno Ramos. These are examples of successful cultural productions articulating a clear critical voice with a high level of aesthetic quality and being recognized as meaningful in Brazil and abroad. I want to understand new aesthetic directions that have affected contemporary cultural production in Brazil during the Bolsonaro years. These new directions indicate changes in the choice of narrative genre as well as the use of rhetoric strategies in order to articulate effective voices of resistance in a country dominated by the far right.
Study of high-speed sintering of fine-grained hard alloys based on tungsten carbide with ultralow cobalt content. I. Pure tungsten carbide
Authors:   National Research Lobachevsky State University of Nizhny Novgorod, Lantsev Е. А. , Malekhonova N. V. ,   National Research Lobachevsky State University of Nizhny Novgorod, Chuvil’deev V. N. ,   National Research Lobachevsky State University of Nizhny Novgorod, Nokhrin А. V. ,   National Research Lobachevsky State University of Nizhny Novgorod, Tsvetkov Yu. V. ,   Baikov Institute of Metallurgy and Material Science RAS, Blagoveshchenskiy Yu. V. ,   Baikov Institute of Metallurgy and Material Science RAS, Boldin M. S. ,   National Research Lobachevsky State University of Nizhny Novgorod, Andreev P. V. ,   National Research Lobachevsky State University of Nizhny Novgorod, Smetanina K. E. ,   National Research Lobachevsky State University of Nizhny Novgorod, Isaeva N. V. ,   Baikov Institute of Metallurgy and Material Science RAS
Published: February 2022

The results of studies of the kinetics of high-speed spark plasma sintering (SPS) of plasma-chemical nanosized and industrial micron tungsten carbide powders are described. During SPS the carburization of the surface layer of tungsten carbide samples takes place, which leads to differences in the phase composition and hardness of the surface and central regions of sintered ceramics. The process of SPS of tungsten carbide can be sequentially represented as a change of the following mechanisms: rearrangement of particles at lower temperatures (Stage I) → sintering of particles due to grain boundary diffusion (Stage II) → sintering due to diffusion in the crystal lattice (Stage III- 1) → sintering under conditions of intensive grain growth with an abnormally low diffusion activation energy (Stage III-2).
Comparative Study on the Direct Current Electrical Conduction in Monolayer and Bilayer Plasma Polymerized Thin Films
Authors: Mohammad Mostofa Kamal , Abu Hashan Bhuiyan
Published: February 2022

A comparative study on the nature of direct current electrical conduction in the monolayer and bilayer plasma polymerized thin films has been discussed in this article. The plasma polymerized pyrrole (PPPy) monolayer, plasma polymerized N,N,3,5-tetramethylaniline (PPTMA) monolayer and plasma polymerized pyrrole-N,N,3,5-tetramethylaniline (PPPy-PPTMA) bilayer thin films were deposited at room temperature onto glass substrates by using a parallel plate capacitively coupled glow discharge reactor. The current density-voltage (J-V) characteristics and the conductivity-voltage (σ-V) characteristics have been studied to analyze the direct current conduction mechanism in PPPy, PPTMA monolayer and PPPy-PPTMA bilayer thin films. The observed results have been presented in this paper. The J-V and σ-V characteristics of PPPy and PPTMA monolayer thin films of different thicknesses indicated an increase in electrical conduction and also an increase in conductivity in the films of lower thicknesses. It is also observed that PPTMA thin films are more conductive than that of PPPy thin films. As a result the PPPy-PPTMA bilayer thin films of different thicknesses and different deposition time ratios indicated an increase in conductivity as the proportion of PPTMA is increased in the films. In addition to that, from the J-V and σ-V characteristics of PPPy, PPTMA and PPPy-PPTMA thin films of same thickness, it is observed that the current conduction and the conductivity in the bilayer thin films is less compared to the monolayer thin films. This unusual result has been explained by studying ideal and real bilayer thin films. It is also seen that in the low voltage region, the current conduction obeys Ohm’s law while the charge transport phenomenon appears to be the space charge limited conduction (SCLC) in the higher voltage regions.
Fuga a tres voces: evolución y tendencias del microrrelato brasileño
Authors: Marques Viana Ferreira Ana Sofia
Published: February 2022

El microrrelato brasileño nace y se desarrolla a la par que las restantes tradiciones literarias latinoamericanas, llegando a los días de hoy con un importante repertorio de obras y de autores. Será nuestro objetivo proporcionar una visión de conjunto del microrrelato brasileño, a fin de perfilar su identidad y sus rasgos definitorios. Para ello, el trabajo contará con la exposición de cuatro apartados. El primero, sobre los precedentes del microrrelato brasileño en sus dos expresiones particulares. El segundo apartado se dedicará a los textos y autores que marcan la irrupción de una estética literaria abocada a lo mínimo surgida sobre todo a partir de los años 60 y consciente de la apertura de un nuevo modelo de lectoescritura. De esas primeras manifestaciones del microrrelato brasileño se despliegan las tres tendencias temáticas y formales del género actualmente, asunto que conformará la tercera sección del presente estudio.
Transformasi Model Bisnis Baitul Maal Wal Tamwil Melalui Design Model Patform
Authors: Wardhana Bayu , Candra Almun Wakhida , Retno Eris Dwi , Monika Lela , Ngulfa Ngafiatul , Rahayu Risky Sari
Published: February 2022

Teknologi saat ini telah mengalami perkembangan dimana semua lini kehidupan masyarakat telah menggunakan teknologi. Teknologi telah masuk kedalam semua sector ekonomi termasuk kedalam sektor keuangan syariah yang dinamakan digitalisasi keuangan. Tetapi disisi lain masih terdapat lembaga keuangan yang belum sepenuhnya menerapkan teknologi dalam model bisnisnya atau dalam pelayanannya. Oleh karena itu didalam penelitian ini akan dibahas inovasi mengenai penerapan teknologi pada baitul maal wal tamwil.
The optimization of multiphase group sequences generated by the nonlinear code multiplexing.
Authors:   «16 Central Research and Testing Institute of the Order of the Red Star named after Marshal of the Communication Troops A.I. Belov» of the Ministry of Defense of Russia, 141006, Moscow Region, Mytishchi, Komarova str. 5, Berdyshev O.YU.
Published: February 2022

This paper presents the challenge of optimization of r-phase group sequences obtained from the nonlinear code multiplexing. It shows that at optimal element wise methodology for group sequences in a full system of r-phase orthogonal sequences, a maximum criterion for the minimum distance of group sequences is equal under certain conditions amounted to a maximum criterion for the minimum module of the integrated correlation response to the data for the orthogonal sequences. For group sequences whish are not under these conditions a maximum criterion for the minimal deviation of the integrated correlation response to the informational orthogonal sequences within the scope of decision – making is received. The algorithm of optimization of group sequences was suggested, which is to achieve this maximum of the minimal deviation by changing the phase of some elements of the group sequence. Additionally, the algorithm of receiving of the entire group sequence among the nearest group sequences was developed. This algorithm provides considerable increasing of immunity while signal data receiving unlike the other algorithm of element-to-element receiving in a system of r-phase orthogonal sequences.
Getting Beyond Parity: Telehealth as a Best Practice in Health Equity
Authors: Philip Andrew , Ford Mary , Goldberg Jordan
Published: February 2022

The global pandemic spurred a rapid uptake of telehealth for nearly all health care providers and has permanently changed how health care is delivered. At present, providers and insurers are grappling with how to balance telehealth and in person care, focusing discussions around reimbursement models and logistical considerations. In this article, the authors discuss whether telehealth can be considered as good a treatment option as in-person care, if it can be even better, and its potential to address equity in access to care. Many opportunities exist with telehealth, from expanding the provider pool for patients to reducing stigma associated with presenting for in-person care. To ensure these opportunities are realized and result in meaningful improvements in eliminating health disparities, they must be approached strategically. The authors propose several considerations for ensuring equity is at the forefront of telehealth implementation discussions and encourage providers, insurers, and advocates to be purposeful in advancing these opportunities.
Saúde bucal defendendo uma saúde planetária
Authors: Rocha da Rosa Arisson
Published: February 2022

Este relato de experiência visa trazer à reflexão todos os atores envolvidos no campo da saúde coletiva, em especial as equipes de saúde bucal, sobre sua atuação e desafios diante das mudanças globais. As realidades dos dois últimos anos (2020-2021) apresentaram-se desafiadoras para as equipes de atenção primária em saúde, as quais se alinharam ao enfrentamento à COVID-19 e mantiveram atenção clínica dando continuidade ao atendimento das necessidades da população. Nesse cenário, a equipe de saúde bucal foi capaz de transcender suas atividades de núcleo técnico para integrar-se ao fronte de combate ao vírus Sars-Cov-2, e, igualmente, proporcionou que temas próprios da saúde coletiva fossem debatidos e n(re)conhecidos por todos que interagem nesse primeiro nível de atenção em saúde, sejam usuários, estudantes em estágio, ou demais colegas de trabalho. A pandemia tornou-se o fulcro para que o cirurgiãodentista e sua equipe assumissem protagonismo pela saúde planetária. A influência dos determinantes sociais, a devastação do meio ambiente e suas implicações, as grandes mobilizações populacionais e migrações, assim como as repercussões do comércio internacional e da economia linear na saúde planetária não são temas rotineiros e remetem a uma importante reflexão nesse período de crise internacional. Atitudes aparentemente pequenas tomadas pela equipe, como apagar a luz de ambientes vazios, selecionar o lixo seco adequadamente, ou optar por lanches saudáveis se mostraram posturas relevantes. Esses pequenos feitos posteriormente a momentos de reflexão coletiva carregam a potencialidade das grandes transformações necessárias para um mundo de mais saúde para todos.