bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of HRM Analysis in Detection of PDGFRA Exon 10 Polymorphism in CML Patients with Imatinib Resistance
Authors: Abd Rashid Nur Sabrina , Sulong Sarina , Husin Azlan , Hassan Rosline , Sidek Mohamad Ros , Mohd Yunus Nazihah
Published: January 2023

Introduction: Imatinib mesylate has been widely used as a standard treatment for chronic myeloid leukemia (CML). It acts as a selective competitive inhibitor of the BCR-ABL tyrosine kinase. Despite the excellent efficacy on CML treatment, some patients developed resistance to the treatment. Mutation in the PDGFRA may be one of the factors involved in the mechanism of resistance that affects the response to imatinib. The mutational status of PDGFRA is highly relevant for prognosis and treatment prediction in CML patients. Thus, this study is intended to establish and validate a High Resolution Melting (HRM) analysis for PDGFRA exon 10 c.1432 T>C polymorphism in CML patients. Methods: High resolution melting (HRM) analysis was used to identify the c.1432 T > C polymorphism in PDGFRA exon 10 (n =86; response = 43; resistance = 43). The results from HRM analysis were compared and validated with Sanger sequencing. The association between the polymorphism and treatment response was assessed by statistical analysis using binomial logistic regression analysis. Results: HRM analyses showed two different melt curves. One curve followed the shape of the reference, homozygous wild type (TT) and the other curve showed a different melting profile than the reference with the TC genotype (heterozygous variant). The results revealed that heterozygous variant (TC) genotype showed a high risk of acquiring resistance with an OR of 3.795; 95% CI: 1.502-9.591, with a statistically significant association, p = 0.005. HRM analysis also showed 100% sensitivity and specificity in the detection of PDGFRA exon 10. Conclusion: The HRM analysis of PDGFRA exon 10 c.1432 T>C was successfully established. The exon 10 c.1432 T>C polymorphism shows a higher risk for the development of resistance toward imatinib treatment.
A Review on Pharmacological Properties of Christia vespertilionis
Authors: Ibrahim Farrah Shafeera , Amom Zulkhairi , Dasiman Razif , Anuar Nazihah
Published: January 2023

Commonly referred to as ‘daun rerama’, Christia vespertilionis has increased in popularity in traditional and modern medicine. This review aims to report the relevance of this plant in terms of its traditional uses, pharmacological actions, phytoconstituents, extractions methods, and identify the research gaps and future potentials. The review is conducted as per PRISMA guidelines; a database search was conducted in Web of Science, Science Direct, Scopus and Google Scholar from 1996 to 2021. Results show that to date, phytochemicals such as alkaloids, flavonoids, quinones, and others have been identified, corresponding to its range of pharmacological activities that include anti-cancer, anti-malaria, and antioxidant. There have also been claims of antidiabetic activity but not supported by enough scientific evidence. Study on molecular and gene expression was still lacking. There is a good future in the research of this plant with many potential aspects to be investigated.
Acute Post-Traumatic Locked Knee - An Unmasking of a Rare Knee Disorder
Authors: Mohd Nizlan Nasir , Abd Ghani Fauzah , Tasarib Rohaman
Published: January 2023

Locked knees are commonly caused by meniscal tears, floating osteochondral bodies, ruptured anterior cruciate ligament (ACL) stump, or other mechanical origins in the knee. Some locked knees occur spontaneously, while in most cases, by a preceding knee trauma. Locked knees are rarely caused by a pathological growth in the knee. More unusually is the occurrence of locked knee caused by a pre-existing pathological entity after a traumatic event. We report a rare case of locking in the knee by a pre-existing knee condition presented only after trauma to the knee. This case emphasizes that locking in the knee can be caused by a pathology that may be asymptomatic until it is revealed by a traumatic event.
Cryptococcal Meningitis Disguised As A Stroke: A Case Report
Authors: Muhamad Damanhuri Fatimahtuz Zahrah , Zakariah Siti Zulaikha , Abdul Ghani Fatimatulzahra
Published: January 2023

We present a case of cryptococcal meningitis initially misdiagnosed as stroke. Our patient is a young man on long-term corticosteroid due to gouty arthritis, who presented with acute onset of left-sided body weakness. Computed tomography of the brain revealed multifocal chronic lacunar infarcts with acute communicating hydrocephalus and cerebrospinal fluid culture isolated Cryptococcus neoformans. He was subsequently treated with amphotericin B and fluconazole but passed away due to multiorgan failure. This case report highlights the importance of considering chronic meningitis as a differential diagnosis when encountering stroke in young and immunocompromised patients.
Upregulation of ppET-1/ETBR/eNOS mRNA Expression After Calcitriol Treatment in Chronic Kidney Diseases Model in Rats
Authors: Ngurah Nata Baskara Anak Agung , Arfian Nur , Wahyu Setyaningsih Wiwit Ananda , Romi Muhammad Mansyur , Ratna Sari Dwi Cahyani
Published: January 2023

Introduction: Myofibroblast formation in the interstitial area is the hallmark of chronic kidney disease (CKD). Endothelin signalling has been known to play role in physiology and pathophysiology in the kidney. Vitamin D has a reno-protective effect through inhibiting inflammation and fibrosis. However, the interaction between vitamin D and endothelin signalling in the CKD model has not been elucidated yet. Therefore, we aimed to check the difference impact of endothelin (ET) receptor in CKD. Methods: Sprague Dawley rats (3-months-old, 150-250grams) underwent 5/6 subtotal nephrectomy (SN) to induce CKD. Then, it was divided into 4 groups (each contains 6 rats): sham operation (SO), 5/6 subtotal nephrectomy (SN), calcitriol groups (0.01µg/100grBW/day (SN-D1), and 0.05µg/100grBW/day (SN-D2). Calcitriol was administered for 14 days after the surgery. The Sham Operation (SO) group was injected with NaCl. At the specified date, the rats were sacrificed and the kidneys were harvested. Fibrosis was quantified based on Sirius Red staining. Immunostaining was done for localizing fibroblast (PDGFRβ). The mRNA expressions of prepro-ET-1, endothelin receptor A (ETAR), endothelin receptor B (ETBR), and endothelial nitrite oxide synthase (eNOS) were quantified using reverse-transcriptase PCR (RT-PCR). Results: The CKD promotes an elevation of prepro-ET-1, ETBR, and eNOS, and reduction of ETAR (p<0.05) mRNA expression compared to the SO group. Administration of calcitriol (SN-D1 and SN-D2) showed the vice versa effects. However, only SN-D2 group consistently showed statistically significant differences whenever compared to either SO or SN groups. Conclusion: Calcitriol might attenuate interstitial fibrosis in CKD model via ET-1/eNOS signalling.
Qualitative Phytochemical Screening and Antibacterial Effect of Averrhoa bilimbi Fruit Extracts Against Selected Bacteria
Authors: Hassan Cheong Nur Dayana , Ibrahim Faizah Saniah , Yusof Hartini
Published: January 2023

Introduction: Most diseases involving bacterial infections have caused high mortality and morbidity rates worldwide. However, the misuse of synthetic antibiotics in treatments has not only caused adverse effects on patients but also led to the emergence of antibiotic-resistant bacteria. The escalating issue of antimicrobial resistance has led to the urgent need for new antimicrobial agents originating from natural resources. Thus, this study was conducted to determine the antibacterial activity of ethyl acetate and aqueous extracts of Averrhoa bilimbi fruits against selected bacteria. Methods: The antimicrobial susceptibility testing (AST) and minimum inhibitory concentration (MIC) by disc diffusion method and microdilution broth method were respectively performed to evaluate the antibacterial activity of the A. bilimbi extract against gram-positive Staphylococcus aureus (ATCC 25923) and Bacillus cereus (ATCC 14579), as well as gram-negative bacteria (Escherichia coli (ATCC 25922) and Salmonella typhimurium (ATCC 13311)). Results: Initial screening for ethyl acetate and aqueous extracts showed inhibition against all microbes with the most significant effects on B. cereus at 16 and 11.67±1.15 mm, respectively. With MIC value of 7.81 mg/ml, the lowest concentration of ethyl acetate extract was required by S. aureus and B. cereus to inhibit their growth. For aqueous extract, the lowest MIC value of 31.25 mg/ml was observed to inhibit E. coli. Moreover, A. bilimbi fruit extracts also contain alkaloids, flavonoids, phenols, terpenoids, tannins, and reducing sugars responsible for antibacterial activities. Conclusion: Therefore, A. bilimbi fruit extract with its potential antibacterial properties can be used as an alternative therapy to combat infectious diseases initiated by the selected pathogens.
Self-Esteem and Quality Of Life among Women with the Menstrual Disorder at a Public Hospital
Authors: Lias Faraliza , Hashim Noraini , Majid Norhaini , Muhamad Norfidah , Wan Ismail Wan Marina , Abd Mulud Zamzaliza
Published: January 2023

Introduction: The regularity of menstrual cycles is considered an important indicator of women’s reproductive health. Menstrual disorders such as dysmenorrhea, menorrhagia, and irregular cycles are common among women in reproductive age groups. They are responsible for physical, behavioural, and emotional changes around the menstruation period, leading to changes of normal routine. This study aimed to determine different types of menstrual irregularity, demographic association, self-esteem, and quality of life of women experiencing menstrual disorders at reproductive age. Methods: A cross-sectional study was conducted using the adopted Rosenberg Self-Esteem Score (RSES) and World Health Organization Quality of Life Assessment (WHOQOL-BREF) questionnaire among 253 women aged 18 to 49 who attended the Gynaecology Clinic at a public hospital in Klang Valley. Results: Dysmenorrhea was observed in 224 (88.5%) women. The majority of the respondent have a normal self-esteem level based on RSES score. The respondent’s quality of life (QOL) score was average between 58 to 62%. Finding revealed a direct linear relationship between self-esteem and quality of life among respondents (p<0.001). According to the domain QOL, positive association for QOL was found with age, educational level, marital status, and body mass index (p<0.005), respectively with physical, social relationship and environment domain. Conclusion: There is a need for the Ministry of Health to evaluate current practice for improving women’s reproductive health through menstruation-efficient interventions, to prevent the negative impact on self-esteem and quality of life. Future research should explore in-depth women’s perceptions to understand better how menstrual problems affect their self-esteem and quality of life.
Pengenalan Manajemen Referensi (Mendeley) Guna Meningkatkan Wawasan Mahasiswa Pra Skripsi Fakultas Ekonomi Universitas Muhammadiyah Buton
Authors: Ridzal Nining Asniar , Malik Ernawati , Hasan Waode Adriani , Sujana I Wayan , Mahmuda Dewi
Published: January 2023

Each university has a goal to improve the quality of human resources and has a good reputation in the surrounding environment. To achieve this, universities need to make a breakthrough. One of them is improving the quality of scientific work by students. For this reason, this activity aims to provide knowledge, understanding, and insight to students of the Faculty of Economics, University of Muhammadiyah Buton about reference management using Mendeley software. This application has a function as a citation tool and bibliography generator. Using this application will make it easier for students when compiling a final project (thesis) by paying attention to the ethics of writing scientific papers so that they can improve the quality of writing Thesis or Scientific Work. The method used in the implementation of this activity is the method of lecture, discussion and practice. The result of this activity is an increase in understanding of Mendeley reference management and an increase in the skills of pre-thesis students in operating the Mendeley application. The success is shown by the activities that run smoothly, the enthusiasm of the participants is quite high, the students have been able to write references and make a bibliography.
Strategi Meningkatkan Pemasaran Pondok Pesantren Baitul Qur’An di Desa Bangkat Monteh, Brangrea, Taliwang, Sumbawa Barat NTB
Authors: Yuliasih Muzayyanah
Published: January 2023

The emergence of modern pesantren has led to competition between pesantren. Therefore, managers of Islamic boarding schools must be able to attract customers through marketing to show the community the benefits that Islamic boarding schools provide to customers so that they can build a positive self-image. Marketing strategies are needed to keep up with developments and face increasingly fierce competition in the future. Baitul Qur'an Islamic Boarding School is located in Bangkat Monte, Brang Rea District, West Sumbawa Regency, NTB Province. The average age of the students in this Islamic boarding school is between 5-12 years, with their parents working as laborers and farmers. This community service activity began with an interest in understanding the importance of strategies to increase the marketing of Islamic boarding schools. So that it can increase the number of students in the future. This will be very beneficial for the management of the pesantren and stakeholders in the pesantren environment. The methods used include discussions, workshops and face-to-face. Educational marketing is carried out by Islamic boarding schools through product differentiation, in the form of several diverse educational programs. The educational program includes drawing and coloring lessons to increase the creativity of students and morning walks outside the boarding school environment to improve the health of students and greet residents around the boarding school. Every impact and effect on the results of the strategy, there must always be preparation to anticipate all possibilities, so that when the number of students who experience positive or negative impacts increases, there is a solution.
Pemberian Edukasi Tata Kelola Keuangan pada Kelompok Usaha Rumahan di Pondok Madina Desa Puntik Barito Kuala
Authors: Yusri Yusri , Yanti Sari , Helmawanti Nava , Fatmala Ella Mauli , Nurhidayah Lilik
Published: January 2023

Entrepreneurs in a business sometimes focus on sales and the turnover target they get. But it is also necessary to regulate the existing financial governance in a recording of transactions both incoming and outgoing in the business or business being carried out. In the conditions found, most small business actors, especially home business actors, sometimes ignore this so that when asked how the movement of cash and capital is only an estimate and cannot clearly show the track record of the transactions that have taken place. With limited knowledge and not understanding how to do a good recording process, of course, this home-based business actor cannot provide a definite picture of the data regarding profits and overall business capital. With the provision of education related to good financial governance, it is hoped that there will be an orderly system in financial management so that business continuity can be measured at the level of financial fundamentals for the short, medium and long term. Even though it is only a simple record management, of course it can describe a good history in the flow of money in and out and other expenditures. This is necessary in measuring the performance and expected targets of a business or business. Mastering accounting in financial governance is expected that the business that is run will not lose but an increase in profit. The provision of this education uses the lecture method, discussion group forums and is carried out face-to-face. A total of 15 participants took part in this activity with 5 household business activities).
Literasi Kearsipan Keluarga Bagi Siswa-Siswi Sekolah Calon Ayah Ibu
Authors: Wisataone Voettie , Rosidah  , Nadia Sasmita Wijayanti  , Danang Setyaramadani
Published: January 2023

The neatness of family archives is still underestimated by the community. A well-managed family archive can provide convenience in finding the family data needed. Negligence in tidying the archives is due to a lack of knowledge and awareness of the community in family archives. This community service provides literacy training on family archives to school of future father and mother’s students. The debriefing was carried out for one month with two stages of implementation. The first stage uses the workshop method, where the service team provides materials and training on procedures for storing archives manually and digitally. Second, using the mentoring method, where participants carry out practice and are directly accompanied by a service team. Of the 19 students who attended the debriefing, 100% stated that the service was very useful and felt that they had an awareness of the family archive. 63% of participants continued to the mentoring stage and 18% of participants were able to complete manual and digital family file fireplaces properly. The process of tidying up family archives requires sufficient time and knowledge so that in the future participants can be given more time so that they can tidy up archives to the maximum.
Implementasi PHBS dengan Dukungan Budaya 5R dalam Pengelolaan Lingkungan Bersih dan Sehat di Pondok Pesantren
Authors: Apriliani Fany , Anggraeni Henny Endah , Resmeiliana Ika , Paramitadevi Yudith Vega
Published: January 2023

Islamic boarding schools are national education providers based on the Islamic curriculum and general education. Education and health must move in tandem so that students can study and do activities well. Problems that often occur in Islamic boarding schools are related to the application of clean and healthy living behavior (CHLB) and 5R culture. The purpose is to know the implementation of CHLB and 5R culture in women's boarding school Thoyyibah Al Islami, Bogor. The methods are training, questionnaires, observation, and designing guide booklets. The results show that the student’s understanding of the 5R culture and PHBS reached 89.5% and 98.3%, respectively. In its implementation, all students stated that they always use the toilet to bathe and defecate, use clean water, and do not smoke or consume drugs. Furthermore, 84.8% of students stated that they always clean their bedrooms and the environment regularly. They always wash their hands with soap and running water reaching 72.7%, and always dispose of garbage in the proper place reaching 69.7%. Meanwhile, students who always consume nutritious food and eradicate mosquitoes are relatively low, at 51.5% and 42.4%, respectively. The guide booklet is designed to increase participation in sustainably managing a clean and healthy environment.
Pelatihan dalam Meningkatkan Pengetahuan dan Keterampilan Karyawan dalam Menganyam Rotan
Authors: Kusumah Adie Irwan , Nurnilasari Nunung
Published: January 2023

The training was carried out for Micro, Small and Medium Enterprises (MSME’s), especially in the medium business category, namely at PT. Prunabon Global Supplies Indonesia which is in Cirebon Regency for 4 (four) days, namely on 17 – 20 October 2022. The factor of a lack of human resources who are less skilled in rattan weaving and the demand for production results is not balanced, will have an impact on how the training method work according to the needs in increasing knowledge and skills. The purpose of the training is to improve capabilities in terms of knowledge and skills of employees so that employees are better and can achieve optimal work results. The method used is the hall method and the demonstration method. The results show that through training, employees improve in terms of knowledge and skills in weaving rattan handicrafts.
 
Abstrak
Pelatihan dilaksanakan pada Usaha Mikro, Kecil dan Menengah (UMKM) terkhusus pada kategori usaha menengah yaitu PT. Prunabon Global Supplies Indonesia yang berada di Kabupaten Cirebon selama 4 (empat) hari yakni pada tanggal 17 – 20 Oktober 2022. Faktor minimnya sumber daya manusia dalam perihal keterampilan pada hal penganyaman rotan juga permintaan daripada hasil produksi tidak seimbang, akan berdampak pada bagaimana metode pelatihan kerja yang disesuaikan dengan keperluan dalam meningkatkan pengetahuan serta keterampilan. Tujuan dari pelatihan untuk meningkatkan kemamampuan dalam hal pengetahuan dan keterampilan karyawan sehingga karyawan lebih baik dan bisa mencapai hasil kerja yang optimal. Metode yang digunakan yaitu metode aula/balai dan metode demonstrasi. Hasilnya menunjukkan bahwa melalui pelatihan, karyawan peningkatan dalam aspek pengetahuan dan keterampilan dalam menganyam kerajian rotan.
Sosialisasi Hukum Konstitusi Tentang Karakter Mulia
Authors: Arlis
Published: January 2023

The main issues of this study are about socializing constitutional law on noble character. The research is aimed at determining students' understanding of constitutional law on noble character. The method used is empirical legal research with an approach to the integration of science and legal intensity. The results showed that after socialization, students understood the constitutional law on noble character. The understanding in question includes noble character in the context of Divine Constitutional Law, Prophetic Constitutional Law, Indonesian Constitutional Law, and Andalasian Character. The classification of noble character is very diverse whose essence is the Qur'an character. The character figure of the Qur'an is the Prophet Muhammad SAW inherited by the ulama. The character of the Qur'an became the best and highest standard of character to improve the morale of the nation. Students understand that the mainstay character is a noble character that is coherent with the character of the Qur'an. Students' understanding is important to be followed up with the application of constitutional law with all laws and regulations and implementing regulations All regulations on character are formulated, determined, and applied imbued with a noble character, namely the Qur’an character.
Pelatihan Kreasi Pembelajaran Tari Bagi Guru Seni Budaya di Bandar Lampung
Authors: Lestari Goesthy Ayu Mariana Devi , Kurniawan Agung , Putra Ricky Marwan
Published: January 2023

The Covid 19 pandemic period presented challenges to all areas of life, including the education sector. The learning process in Indonesia had to be incidentally diverted towards online learning. Constraints and challenges are faced especially for practical learning characteristics, such as arts and culture subjects with main topics such as dance. To get around this, it is necessary to motivate the creativity of arts and culture teachers through training in the creation of art learning, especially dance learning. This activity instills knowledge and skills for teachers to be creative in developing dance learning in arts and culture subjects. This is present as a joint solution in seeking to keep the arts and culture learning process running and the final competence of students can be achieved as expected. The training method is carried out using lecture techniques, discussions and online practice. Through this training, 60% of the participants are confident in designing Blended Learning art and culture learning with more interesting learning media. This activity can help these teachers to design creative and informative learning media with an average achievement of 84.85 which is classified as "very good".  This is a positive indication of the teacher's ability to develop creations in learning arts and culture subjects in schools online.
Penyuluhan Komunikasi Non Verbal Pada Himpunan Pramuwisata Indonesia (HPI) Kabupaten Bogor
Authors: Satriani Imani , Cahyaningrum Qoute Nuraini
Published: January 2023

Tourism in Bogor Regency always has its own charm for tourists. Tourism activities in Bogor close related with tourguide. Himpunan Pramuwisata Indonesia  (HPI) Bogor is an organization who cope tour  guides in Bogor Districts. Tour guide must have communication ability besides knowledge of tourist destination.  Communication divided into verbal and non verbal communication. Verbal communication like oral and written communication. Non verbal communication like facial expression, gesture, dialect, etc. This Non Verbal Communication counseling is a part of community serices activity with title Public Speaking and Non Verbal Communication for Tourist Guide. This activity aims to optimize tour guide’s knowledge about nonverbal communication and to optimize tour guide’s knowledge about nonverbal communication and it impelementations in tourism activities. Methodes of this PKM implementation are lecture method, disscused and feedback collection method. The results of this community service activities including that HPI members become knowledgeable about non verbal communication in general. HPI members also become knowledeable about non verbal communication for tourism activities.
Representation of Pantheism as Collective Identity with Reference to the Poetry of William Hennery Davies and Wendell Berry.
Authors: Ibrahim Musa Abubker Tijani
Published: January 2023

This study presented pantheism as question of identity or in fact collective identity. Generally, the concept of identity means collection of characteristics, abilities, goals, temperament and values that distinguish one individual from another. Throughout this study the researcher enlarged the concept of identity to include every single entity more over all these seemingly different beings with their various Features are brought together into a new one concept called pantheism that is everything is one and all is god. The researcher used qualitative: analytical descriptive, interpretive and deconstructive methods to fulfill the study goals. Pantheistic view creates peaceful atmosphere in the general life. It relates all entities one to the other through maintaining the concept of unity and one orientation. Considering pantheism as matter of identity would bring to the world a new aesthetic flavor that let everyone loves everything no matter whom or what it is, in fact it is hers, his or itself at some level. Ignorance and greed are what complicate this life and mad it boring sometimes because everyone works to defeat anyone in order to win alone.

مستخلص

قدمت هذه الدراسة وحدة الوجود على أنها مسألة هوية أو في الواقع هوية جماعية. يعني مفهوم الهوية عمومًا مجموعة الخصائص والقدرات والأهداف والمزاج والقيم التي تميز فردًا عن الآخر. خلال هذه الدراسة قام الباحث بتوسيع مفهوم الهوية ليشمل كل كيان على حدة أكثر من كل هذه الكائنات التي تبدو مختلفة مع ميزاتها المختلفة مجتمعة في مفهوم واحد جديد يسمى وحدة الوجود التي هي كل شيء واحد وكل شيء هو الله. استخدم الباحث المنهج النوعي: التحليلي الوصفي والتفسري والتفككي لتحقيق أهداف الدراسة. النظرة الوجودية تخلق جوًا سلميًا في الحياة العامة. وهي تربط جميع الكيانات بعضها ببعض من خلال الحفاظ على مفهوم الوحدة والتوجه الواحد. إن اعتبار وحدة الوجود على أنها مسألة هوية من شأنه أن يجلب للعالم نكهة جمالية جديدة تتيح للجميع أن يحبوا كل شيء بغض النظر عن من هو أو ما هو ، في الواقع  هو/لها أو هو أو نفسها على مستوى ما . الجهل والجشع هما ما يعقد هذه الحياة ويجعلها مملة أحيانًا لأن الجميع يعمل على هزيمة أي شخص من أجل الفوز بمفرده.
Assessing the Entrepreneurship Ecosystem in Egypt through a Gender Lens
Authors: Hattab Hala Wasef
Published: January 2023

Purpose: According to the Egyptian Start-up Ecosystem Report (ITIDA, 2021), Egypt has one of the foremost start-up ecosystems on Africa, both in terms of levels of start-up activity and inward investments. Yet the county lags in terms of women’s participation in founding start-ups. According to the latest Global Entrepreneurship Monitor report for Egypt, the entrepreneurial activity rate for women was 5.7%, while that of Egyptian men was 16.7%, despite women’s positive attitudes towards entrepreneurship.

Methodology: The current research has an exploratory nature and aims at analysing entrepreneurship ecosystem in Egypt through a gender lens to highlight the factors that are hindering Egyptian women from exploiting the different elements of the ecosystem. To achieve this, it adopts the exploratory research approach combining semi-structured interviews with ten women entrepreneurs chosen using expert sampling and an online survey distributed via Egyptian entrepreneurs’ online communities.

Findings: Analysis shows that Egyptian women entrepreneurs do not believe that the ecosystem discriminates against them, but there are some practices that are gender-insensitive which poses challenges to women hence impact their presence and activities within the ecosystem.

Unique contribution to theory, policy and practice: The results add to the literature of both entrepreneurship ecosystem and women entrepreneurship in Egypt and it provides practical implications to leverage Egyptian women participation in entrepreneurship.
Virtual Mouse by Means of Manual Gestures
Authors: L. Prabhavathi  , K. Indhira  , C. Dilli Rani  , A. Meena  , B. Mohan Sai  , A. Poornesh
Published: January 2023

The main aim to perform the mouse cursor operations and scrolling function and also move the cursor. A professional webcam, novel process of managing mouse click was developed. The integration of different efforts would include changing keypad elements, integrating more keys, or shifting the monitoring ball's placement. However, they recommend that the hardware design be altered. The proposed approach solves present inadequacies as well as utilized of a hardware mouse, but also numerous motions cause injury in the palms. It should be predicated on a visualization impact of motion, accompanied by artificial intelligence technology, image classification, and motion tracking, to regulate mouse tasks (left and right-clicking, double- clicking, and scrolling), as well as Machine Cognitive approach to obtain a greater virtual touchpad to the current systems. A camera should be used to capture palm motions.
Klangvoll ins neue Jahr starten
Authors: von Rekowski Elke
Published: January 2023

Musiksysteme: Ob selbst gemacht, gemixt oder gehört: Musik zählt für viele Menschen zu den unverzichtbaren Freuden und Genüssen. VDI nachrichten haben sich einige dieser Geräte für die Hi-Fidelisten unter unserer Leserschaft mal genauer angeschaut. Von Elke von Rekowski
Effect of probiotics on olanzapine-induced metabolic syndrome in Wistar albino rats
Authors: Syed Mushraf , Nayak Veena
Published: January 2023

Introduction and Aim: Olanzapine is the most efficacious second-generation antipsychotic (SGA) used in the treatment of schizophrenia and at the same time, it is known to cause metabolic syndrome (MS). The aim was to assess the adequacy of probiotics in fighting the unfriendly impacts of olanzapine treatment such as weight gain, hyperlipidaemia, and hyperglycaemia in the olanzapine-induced MS model in rats.
 
Materials and Methods: Thirty-six Wistar rats were divided into six groups (n=6), and were treated for 28 days as follows: Group-I: normal saline 1 ml/kg/day orally, Group-II: olanzapine 2 mg/kg/day i.p., Group-III: probiotic: 0.6 g/kg/day orally, Group-IV: probiotic: 1.2 g/kg/day orally, Group-V: olanzapine 2 mg/kg/day i.p., + probiotic: 0.6 g/kg/day orally, Group-VI: olanzapine 2 mg/kg/day i.p. + probiotic: 1.2 g/kg/day orally. Bodyweight, fasting blood glucose (FBG), and lipid profile were assessed at baseline and the end of each week. Data were analysed by applying repeated measures ANOVA, followed by a post-hoc Bonferroni test. P-value <0.05 was considered statistically significant.
 
Results: There was a significant increment in the body weight, FBG, total cholesterol, and triglycerides level after olanzapine treatment (p<0.001), and similarly a decline in the body weight, FBG, total cholesterol, and triglycerides level in the probiotic-treated groups (p<0.001). There was a decrease in weight gain and FBG levels caused by olanzapine in the probiotic-treated groups.
 
Conclusion: Probiotics forestalled the advancement of hyperlipidaemia, hyperglycaemia, decreased weight, and an increase in FBG levels induced by olanzapine. A long-term evaluation should also be directed to assess probiotics' impact on olanzapine-induced MS and their plausible mechanism.
Spectrum of eyelid malignancies at a tertiary care hospital in coastal India
Authors: Maria D’ Souza Shirley , Shenoy K. Kamalaksha , S. Rao Purnima
Published: January 2023

The eyelid has four layers: skin and the subcutis, orbicularis oculi muscle, tarsal plates (one in each eyelid) and the conjunctiva. Tumors can arise from any of these and can range from non-neoplastic masses to neoplasms that include benign tumors, premalignant conditions and malignancies. The malignant tumors are of different histologic types depending upon the region and tissue of origin. Malignant tumors, especially basal cell and squamous cell carcinomas, are common in the skin around the eyes. Early detection and treatment are crucial due to the location of the tumors and is cosmetically and functionally important. Eyelid tumors are rare and most ophthalmologists/ pathologists will see only a handful in the course of their career.
 
In this case series, we describe seven cases with different types of eyelid malignancies, the clinical and pathologic features of these patients who presented with various tumors of the eyelid to our tertiary care teaching hospital in coastal India.
İzole Sıçan Mesane Detrusor Kasında Omeprazolün Etkisi ve Bu Etkide Rac-1 Yolağının Rolü
Authors: Balcı Hakan , Akyüz Bahar , Bilge Süleyman Sırrı
Published: January 2023

ABSTRACT The Effect of Omeprazole on Isolated Rat Bladder Detrusor Muscle and the Role of the Rac-1 Pathway in This Effect Introduction: The urinary retention problem reported in some patients using omeprazole and other proton pump inhibitors suggests that this drug has this effect by relaxing the bladder smooth muscle. Studies with omeprazole and other proton pump inhibitors show that these drugs cause relaxation in various tissue and organ smooth muscles, which also supports our hypothesis. However, there is no study in the literature about the possible effect and mechanism of action of omeprazole on bladder smooth muscle. The aim of this study is to investigate the possible effect and mechanism of action of omeprazole in isolated rat bladder detrusor muscle. Materials and Methods: In the presence of omeprazole (10-4, 5x10-4, 10-3 M), contraction responses induced by acetylcholine (10-6-10-3 M) and electrical field stimulation (2-64 Hz) were measured. Rac-1 pathway inhibitor NSC23799 (10-4 M) was used to investigate the mechanism of action of omeprazole. One-way analysis of variance (ANOVA) and Tukey-Kramer post-hoc test were used for statistical analysis. Results: Omeprazole (10-4, 5x10-4, 10-3 M) dose-dependently inhibited maximal contraction responses induced by acetylcholine and electrical field stimulation. When omeprazole (5x10-4 M) was applied in combination with NSC23766, it caused a significant increase in ACh and EFS-induced responses compared to the NSC23766 alone group. Conclusion: These results show that omeoprazole inhibits contractions in isolated rat detrusor muscle through blockade of rac-1 pathway. Keywords: Detrusor Muscle, Omeprazole, Rac-1 Pathway, Rat
Narratologia cognitiva: dinâmicas afetivas e estruturação do enredo ficcional à luz de teorias da afetividade situada
Authors: Chagas Pedro Ramos Dolabela , Carvalho Felipe Nogueira de , Batistela Ayla Mello
Published: January 2023

O propósito deste artigo é aprofundar o debate da narratalogia cognitiva sobre o papel das emoções e afetos na escrita e leitura do texto ficcional. Para tanto, buscamos fundamentos teóricos em teorias recentes da afetividade situada, em particular nos conceitos de andaimes, arranjos e milieus afetivos, a fim de observar como textos codificam afetos para suscitar estados afetivos e emocionais nos leitores. O mérito da interlocução virá da capacidade de fertilizar a compreensão do papel das emoções na construção de textos ficcionais, mediante a análise do seu papel na composição de um texto em particular: o conto “Criançada”, de Anton Tchekhov. Como teorias da afetividade situada reservam um papel de destaque para o ambiente externo na construção da afetividade humana, argumentamos que a aplicação dessas teorias ao nosso objeto permite observar como a construção do espaço, a descrição dos objetos e os afetos dos personagens estão intimamente ligados, alimentando-se reciprocamente e fortalecendo-se em relações de feedback. Essas análises podem permitir que a narratologia cognitiva saliente elementos afetivos dos textos ficcionais até aqui pouco explorados nos estudos literários.
Knowledge and awareness of dentists on child abuse and neglect in Türkiye
Authors: Aşık Aslı , Eden Ece
Published: January 2023

Aim: Child abuse and neglect (CAN) may be defined as physical, sexual and/or psychological maltreatment of the child. The purpose of this paper was to evaluate the knowledge and awareness of dentists about CAN, to give basic information on the topic and to take feedback. Methods: It was an observational study that the questionnaire that consisted 26 questions in four parts was sent by e-mail with an electronic link via Turkish Dental Association to Turkish dentists. At the end of the questionnaire, a short education by power-point presentation was given to volunteered participants and self-competence feedbacks were taken. Results: A total of 326 dentists (113 males and 213 females) aged 23-70 years, answered the questionnaire. Only 16.2% of dentists reported that they know their legal rights and information on reporting CAN. 79.5% of dentists noted that they did not receive education on CAN during their undergraduate years. 95.6% of the participants volunteered to attend the education provided. Feedbacks showed that information obtained by the education had a beneficial impact on dentists’ awareness and knowledge. Conclusions: Turkish dentists’ knowledge and awareness of CAN were inadequate. Educational efforts may enable them to recognize cultural misperceptions, take necessary precautions, to be confident in reporting child abuse and neglect without hesitation and fulfill their legal obligations.
Gereja sebagai ibu dan mempelai
Authors: Margaret Carmia
Published: January 2023

Kaum Injili dikenal memiliki penekanan tinggi terhadap aspek soteriologi, akan tetapi di sisi lain justru memiliki konstruksi eklesiologi yang tipis. Untuk mengatasi ketimpangan ini, perlu membangun sebuah pandangan teologis yang lebih apresiatif dan proporsional terhadap natur dan identitas gereja. Mengacu pada identitas kaum Injili yang mengakarkan diri pada otoritas Kitab Suci, maka pandangan terhadap gereja juga seharusnya dibangun atas dasar refleksi ulang terhadap gambaran-gambaran  Alkitab itu sendiri tentang keberadaan gereja. Artikel ini hendak mengusulkan penghayatan kembali terhadap gambaran tentang gereja sebagai anak dara atau pengantin yang menantikan mempelainya yaitu Kristus; sekaligus sebagai Ibu yang mengasuh orang percaya. Pembacaan yang diusulkan ialah bahwa figur Maria ibu Yesus dapat menjadi model bahwa gereja adalah entitas yang diciptakan Allah melalui Roh dan firman dari dalam kekosongan, serta dipanggil untuk mengusung dan menghadirkan Kristus di dalam dunia yang berdosa, sekalipun harus melewati tahapan mengerang dan sakit bersalin.
COMPARISON OF THE PERFORMANCE OF GRADIENT BOOSTING, LOGISTIC REGRESSION, AND LINEAR SUPPORT VECTOR CLASSIFIER ALGORITHMS IN CLASSIFYING TRAVEL MODES BASED ON GNSS DATA
Authors: Shamohammadi O. , Pahlavani P. , Sharifi M. A.
Published: January 2023

Abstract. Public transportation system capacity must be compatible with the frequency of daily trips. Smart mobile phones can collect positioning data at different times, which can detect transportation modes people use for their daily commutes. This information helps the government predict how many vehicles are needed to satisfy public transportation system demands. This article investigates the performance of three different machine learning models, including Gradient Boosting (GB), Logistic Regression (LR), and linear Support Vector Classifier (SVC) in classifying the trip types. Thirty-nine features, including statistical parameters of velocity, acceleration, and jerk, and also parameters representing the time of each trip, are given to the models as input. To increase the performance of the models, with the help of thresholding, points corresponding to noise are detected and removed from the dataset. Moreover, to fill the possible gaps and smooth the trajectories, spline interpolation and Savitzky-Golay filter are also investigated in feature calculation. The results show that the linear models are incapable of distinguishing between different classes well and they are over-fitted to classed with more samples. Hence, the GB by 0.93 recall, precision, and F-score was the best model in determining the vehicle used compared to LR and linear SVC.
RETROSPECTIVE STUDY OF VERTICAL GROUND DEFORMATION IN COMO, NORTHERN ITALY: INTEGRATION OF LEVELLING AND PSI MEASUREMENTS
Authors: Eskandari R. , Scaioni M.
Published: January 2023

Abstract. Subsidence-related vertical ground deformation due to natural and anthropogenic factors may lead to considerable damages to structures and infrastructures, and may increase the occurrence probability of consequential events, such as floods, especially on sea and lake shores. Como city, placed in the north of Italy, adjacent to Como Lake, is subjected to significant subsidence phenomenon, which has been monitored by geodetic levelling networks. In this work the historical geodetic levelling measurements and satellite-based Synthetic Aperture Radar (SAR) data archive are integrated to assess the accuracy of Atmospheric Delay and Deformation Rate estimations obtained through Persistent Scatter Interferometry (PSI) techniques. Tree levelling measurement datasets acquired in 1990, 1997 and 2004 are used in order to obtain the precise deformation rate at the benchmarks for two periods of 1990–1997 and 1997–2004. For multi-temporal InSAR analysis, 106 SAR images (1992–2004) and 41 SAR images (1992–2004) in Ascending Track orbit from ERS-1/2 missions are used in this study. The assessment is performed through a statistical comparison between two sets of vertical land deformation rates obtained by integrated methods. The results of the validation represented a good consistency between deformation rates derived by both techniques. Also, this study has revealed the potential of SAR images acquired in gyro-less mode by ERS-2 mission (2001–2004) in terms of the estimation of ground deformation.
СПІВВІДНОШЕННЯ ГАРАНТІЙ РЕАЛІЗАЦІЇ ПРИНЦИПУ ПІДЗВІТНОСТІ ОРГАНІВ МІСЦЕВОГО САМОВРЯДУВАННЯ З ІНСТИТУТОМ ВІДПОВІДАЛЬНОСТІ
Authors: Голик Юрій Юрійович
Published: January 2023

У статті розглянуто питання співвідношення гарантій реалізації принципу підзвітності органів місцевого самоврядування з інститутом відповідальності. Наголошено, що реалізація принципу народовладдя місцевого самоврядування відбувається через його правову, організаційну та матеріально-фінансову самостійність. Така автономія не буде ефективною без комплексної реалізації інших принципів місцевого самоврядування, які виступають у ролі стримувань та противаг для максимального захисту прав та свобод громадян. Ідеться про принцип підзвітності та відповідальності місцевого самоврядування перед територіальними громадами. Наголошено, що пізнання сутності гарантій реалізації принципу підзвітності та відповідальності органів місцевого самоврядування дозволяє їх відрізнити від інституту відповідальності. Якщо головне призначення гарантій полягає у забезпеченні досягнення блага чи інтересу, то призначення відповідальності – відновлення порушеного права. Стверджується, що реалізація будь-якого суб’єктивного права являє собою певний процес, що триває в часі, але все ж таки ним обмежений. У ході реалізації права відповідальність виникає після порушення протиправним впливом безперешкодного його використання, порушення розпоряджень норм про права. Акцентовано, що гарантії місцевого самоврядування – необхідна для реалізації повноважень обстановка та спеціальний механізм, що забезпечують безперешкодну ефективну участь місцевого самоврядування у вирішенні питань місцевого значення, вираження волі та інтересів відповідної територіальної громади. Підкреслено, що гарантії реалізації принципу підзвітності та відповідальності органів місцевого самоврядування не ототожнюються з інститутом відповідальності. Головне призначення гарантій полягає у забезпеченні досягнення блага чи інтересу, а відповідальності – відновлення порушеного права, тобто відновленні можливості певної поведінки, порушеної протиправним впливом. Відповідальність виступає засобом підвищення соціальної активності та високої самодисципліни громадян, звертає увагу на посилення виховної роботи, що дозволить більш ефективно здійснювати місцеве самоврядування.
Translation, politics, and development
Authors: Tekwa Kizito , Li Mei
Published: January 2023

China’s rise to global prominence has been coupled with a development aid approach and narrative that contradicts long-standing Western-oriented models and discourses. Despite the existence of tangible development projects that bear testimony to Chinese aid to developing countries and which clearly espouse the principles upon which the aid is founded, critics continue to allege that the aid is a façade that enables China to advance its political ideology and vision. Using a corpus-based approach, we investigated the extent to which China’s political discourse finds its way into the development aid discourse either by senior party officials or through a government-managed collaborative translation mechanism. To do so, we designed a monolingual corpus of the speeches of top-ranking CPC party officials presented at party-organized events and bilingual (Chinese–English) corpora of the discourse used by Chinese government officials during development aid exchanges. We extracted political terms, based mostly on their frequency of use, from the monolingual corpus and verified the extent of their presence in the bilingual corpora of the development aid discourse. Furthermore, we studied the terms and their contexts of use in the bilingual corpora to determine whether translation served as a medium through which China’s political discourse was possibly being introduced into its development aid discourse. Our investigation led us to conclude that China’s development aid discourse contains an insignificant amount of political terminology mirroring China’s own development path. We also concluded that translation did not constitute, in any tangible way, a means by which the presence of China’s political discourse in its development aid discourse could be enhanced. However, we uncovered issues related to terminology management, literal translation, and machine translation which suggest that China was struggling to cope with preserving source text and, presumably, target text linguistic and cultural elements, while taking advantage of current advances in translation technology. We propose both structural and translational modifications that could help China curb anti-development aid criticism while enhancing its development aid discourse.