bluuebunny/crossref_metadata_2025 huggingface dataset:
Influences of Molecular Weights on Physicochemical and Biological Properties of Collagen-Alginate Scaffolds
Authors: Ho Truc Cong , Park Jin-Seok , Kim Sung-Yeoul , Lee Hoyeol , Lim Ju-Sop , Kim Shin-Jun , Choi Mi-Hee , Nam Seung Yun , Chun Byung-Soo
Published: February 2021

For tissue engineering applications, biodegradable scaffolds containing high molecular weights (MW) of collagen and sodium alginate have been developed and characterized. However, the properties of low MW collagen-based scaffolds have not been studied in previous research. This work examined the distinctive properties of low MW collagen-based scaffolds with alginate unmodified and modified by subcritical water. Besides, we developed a facile method to cross-link water-soluble scaffolds using glutaraldehyde in an aqueous ethanol solution. The prepared cross-linked scaffolds showed good structural properties with high porosity (~93%) and high cross-linking degree (50–60%). Compared with collagen (6000 Da)-based scaffolds, collagen (25,000 Da)-based scaffolds exhibited higher stability against collagenase degradation and lower weight loss in phosphate buffer pH 7.4. Collagen (25,000 Da)-based scaffolds with modified alginate tended to improve antioxidant capacity compared with scaffolds containing unmodified alginate. Interestingly, in vitro coagulant activity assay demonstrated that collagen (25,000 Da)-based scaffolds with modified alginate (C25-A63 and C25-A21) significantly reduced the clotting time of human plasma compared with scaffolds consisting of unmodified alginate. Although some further investigations need to be done, collagen (25,000 Da)-based scaffolds with modified alginate should be considered as a potential candidate for tissue engineering applications.
Is the Rationale of Anatomical Liver Resection for Hepatocellular Carcinoma Universally Adoptable? A Hypothesis-Driven Review
Authors: Lin Young-Jen , Ho Cheng-Maw
Published: February 2021

Surgical resection is the first-line curative treatment modality for resectable hepatocellular carcinoma (HCC). Anatomical resection (AR), described as systematic removal of a liver segment confined by tumor-bearing portal tributaries, may improve survival by reducing the risk of tumor recurrence compared with non-AR. In this article, we propose the rationale for AR and its universal adoption by providing supporting evidence from the advanced understanding of a tumor microenvironment and accumulating clinical experiences of locoregional tumor ablation therapeutics. AR may be advantageous because it completely removes the en-bloc by interrupting tumor vascular supply and thus extirpates the spreading of tumor microthrombi, if they ever exist, within the supplying portal vein. However, HCC is a hypervascular tumor that can promote neoangiogenesis in the local tumor microenvironment, which in itself can break through the anatomical boundary within the liver and even retrieve nourishment from extrahepatic vessels, such as inferior phrenic or omental arteries. Additionally, increasing clinical evidence for locoregional tumor ablation therapies, such as radiofrequency ablation, predominantly performed as a non-anatomical approach, suggests comparable outcomes for surgical resection, particularly in small HCC and colorectal, hepatic metastases. Moreover, liver transplantation for HCC, which can be considered as AR of the whole liver followed by implantation of a new graft, is not universally free from post-transplant tumor recurrence. Overall, AR should not be considered the gold standard among all surgical resection methods. Surgical resection is fundamentally reliant on choosing the optimal margin width to achieve en-bloc tumor niche removal while balancing between oncological radicality and the preservation of postoperative liver function. The importance of this is to liberate surgical resilience in hepatocellular carcinoma. The overall success of HCC treatment is determined by the clearance of the theoretical niche. Developing biomolecular-guided navigation device/technologies may provide surgical guidance toward the total removal of microscopic tumor niche to achieve superior oncological outcomes.
Effect of MgO Content on the Viscosity, Foaming Life, and Bonding in Liquid and Liquid/Solid CaO-SiO2-MgO-5Al2O3-30FeO Slags
Authors: Chang Yu-En , Lin Chi-Ming , Shen Jyun-Ming , Chang Wei-Ti , Wu Weite
Published: February 2021

The CaO-SiO2-MgO-5Al2O3-30FeO five (oxide) components slag system was studied by varying the magnesium oxide (MgO) content (5.7–13.6 wt.%.% MgO) and keeping the basicity constant). The data were analyzed using the FactSage software. It was observed that the liquid network structure and precipitation of solid particles had an impact on high-temperature viscosity and foaming life. Under the same basicity (mass ratio CaO/SiO2 = 1.5) and at a temperature of 1500 °C, the MgO content was varied as 5.7 wt.%, 7.4 wt.%, 9.6 wt.%, 11.5 wt.%, and 13.6 wt.% in A0~A5. The solid fractions of different samples were estimated with FactSage software and found to be A0–A2 (0 wt.%), A3 (2.77 wt.%), A4 (6.92 wt.%), A5 (11.7 wt.%). The viscosities of A0–A5 measured at 1500 ·C were 22, 47, 40, 76, 363, and 1088 mPa×s, respectively, and the foaming life was 2.0 min, 7.7 min, 6.2 min, 13.4 min, 16.8 min, and 18.0 min, respectively. It was found that A5 exhibits the best effective foaming life under these environmental conditions because it can ex-hibit a double foaming effect formed by the precipitation of solid particles. The Si-O-Si network in liquid slag also contributed to foaming life, when there was only liquid slag bonding in the slag, the effective foaming life was 7.7 min. In the absence of these factors, the foaming life was only 2 min.
[CrIII8NiII6]n+ Heterometallic Coordination Cubes
Authors: O’Connor Helen M. , Sanz Sergio , Scott Aaron J. , Pitak Mateusz B. , Klooster Wim T. , Coles Simon J. , Chilton Nicholas F. , McInnes Eric J. L. , Lusby Paul J. , Weihe Høgni , Piligkos Stergios , Brechin Euan K.
Published: February 2021

Three new heterometallic [CrIII8NiII6] coordination cubes of formulae [CrIII8NiII6L24(H2O)12](NO3)12 (1), [CrIII8NiII6L24(MeCN)7(H2O)5](ClO4)12 (2), and [CrIII8NiII6L24Cl12] (3) (where HL = 1-(4-pyridyl)butane-1,3-dione), were synthesised using the paramagnetic metalloligand [CrIIIL3] and the corresponding NiII salt. The magnetic skeleton of each capsule describes a face-centred cube in which the eight CrIII and six NiII ions occupy the eight vertices and six faces of the structure, respectively. Direct current magnetic susceptibility measurements on (1) reveal weak ferromagnetic interactions between the CrIII and NiII ions, with JCr-Ni = + 0.045 cm−1. EPR spectra are consistent with weak exchange, being dominated by the zero-field splitting of the CrIII ions. Excluding wheel-like structures, examples of large heterometallic clusters containing both CrIII and NiII ions are rather rare, and we demonstrate that the use of metalloligands with predictable bonding modes allows for a modular approach to building families of related polymetallic complexes. Compounds (1)–(3) join the previously published, structurally related family of [MIII8MII6] cubes, where MIII = Cr, Fe and MII = Cu, Co, Mn, Pd.
Phytochemical Investigation and Antioxidant Activity of Globularia alypum L.
Authors: Asraoui Fadoua , Kounnoun Ayoub , Cadi Hafssa El , Cacciola Francesco , Majdoub Yassine Oulad El , Alibrando Filippo , Mandolfino Filippo , Dugo Paola , Mondello Luigi , Louajri Adnane
Published: February 2021

The Moroccan flora is rich in medicinal plants that are commonly used in folk medicine for the treatment of various diseases. The present study was designed to investigate the total phenolic and flavonoid contents, as well as the antioxidant properties of leaves extracts from Globularia alypum L. colected from the Taza region in northeast Morocco. Additionally, the individual phenolics and volatiles of the extracts were also evaluated. The organic extracts of this plant were obtained by Soxhlet extraction using two different solvents, namely ethyl acetate and chloroform. The antioxidant capacity of leaves extracts was measured using DPPH, ABTS and FRAP assays; the phenolic profile was determined by HPLC-DAD/ESI-MS analysis, whereas the volatile composition was elucidated by GC-MS. The ethyl acetate extract analysis showed a total of 20 phenolic compounds and the determination of phenolic contents showed a significant value of 56.5 ± 0.61 µg GAE/mg of extract in comparison with the chloroform extract (18.9 ± 0.48 µg GAE/mg of extract). Also, the determination of the flavonoid contents revealed that the ethyl acetate extract contained the highest value (30.2 ± 0.55 µg CE/mg of extract) in comparison with the chloroform extract (18.0 ± 0.36 µg CE/mg of extract). Concerning the antioxidant properties, interesting values were attained for the ethyl acetate extract which exhibited higher antioxidant activity, namely IC50 = 12.3 ± 3.83 µg/mL and IC50 = 37.0 ± 2.45 µg/mL for the DPPH and ABTS assays, respectively, whereas a value of 531.1 ± 17.08 (mg AAE/g DW) was obtained for the FRAP assay. Concerning the volatile profile, a total of 73 compounds were positively detected and among them n-hexadecanoic acid (13.5%) was the most abundant one. The results achieved confirm the important role of this plant as a source of natural antioxidants.
Sulfonate-Conjugated Polyelectrolytes as Anode Interfacial Layers in Inverted Organic Solar Cells
Authors: Lassi Elisa , Squeo Benedetta Maria , Sorrentino Roberto , Scavia Guido , Mrakic-Sposta Simona , Gussoni Maristella , Vercelli Barbara , Galeotti Francesco , Pasini Mariacecilia , Luzzati Silvia
Published: February 2021

Conjugated polymers with ionic pendant groups (CPEs) are receiving increasing attention as solution-processed interfacial materials for organic solar cells (OSCs). Various anionic CPEs have been successfully used, on top of ITO (Indium Tin Oxide) electrodes, as solution-processed anode interlayers (AILs) for conventional devices with direct geometry. However, the development of CPE AILs for OSC devices with inverted geometry is an important topic that still needs to be addressed. Here, we have designed three anionic CPEs bearing alkyl-potassium-sulfonate side chains. Their functional behavior as anode interlayers has been investigated in P3HT:PC61BM (poly(3-hexylthiophene): [6,6]-phenyl C61 butyric acid methyl ester) devices with an inverted geometry, using a hole collecting silver electrode evaporated on top. Our results reveal that to obtain effective anode modification, the CPEs’ conjugated backbone has to be tailored to grant self-doping and to have a good energy-level match with the photoactive layer. Furthermore, the sulfonate moieties not only ensure the solubility in polar orthogonal solvents, induce self-doping via a right choice of the conjugated backbone, but also play a role in the gaining of hole selectivity of the top silver electrode.
Phytochemistry, Bioactivities, Pharmacokinetics and Toxicity Prediction of Selaginella repanda with Its Anticancer Potential against Human Lung, Breast and Colorectal Carcinoma Cell Lines
Authors: Adnan Mohd , Siddiqui Arif Jamal , Hamadou Walid Sabri , Patel Mitesh , Ashraf Syed Amir , Jamal Arshad , Awadelkareem Amir Mahgoub , Sachidanandan Manojkumar , Snoussi Mejdi , De Feo Vincenzo
Published: February 2021

In this study, we investigated the bioactive potential (antibacterial and antioxidant), anticancer activity and detailed phytochemical analysis of Selaginellarepanda (S. repanda) ethanolic crude extract for the very first time using different in vitro approaches. Furthermore, computer-aided prediction of pharmacokinetic properties and safety profile of the identified phytoconstituents were also employed in order to provide some useful insights for drug discovery. S. repanda, which is a rich source of potent natural bioactive compounds, showed promising antibacterial activity against the tested pathogenic bacteria (S. aureus, P. aeruginosa, E. coli and S. flexneri). The crude extract displayed favorable antioxidant activity against both 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50 = 231.6 μg/mL) and H2O2 (IC50 = 288.3 μg/mL) molecules. S. repanda also showed favorable and effective anticancer activity against all three malignant cancer cells in a dose/time dependent manner. Higher activity was found against lung (A549) (IC50 = 341.1 μg/mL), followed by colon (HCT-116) (IC50 = 378.8 μg/mL) and breast (MCF-7) (IC50 = 428.3 μg/mL) cancer cells. High resolution-liquid chromatography–mass spectrometry (HR-LC–MS) data of S. repanda crude extract revealed the presence of diverse bioactive/chemical components, including fatty acids, alcohol, sugar, flavonoids, alkaloids, terpenoids, coumarins and phenolics, which can be the basis and major cause for its bioactive potential. Therefore, achieved results from this study confirmed the efficacy of S. repanda and a prospective source of naturally active biomolecules with antibacterial, antioxidant and anticancer potential. These phytocompounds alone with their favorable pharmacokinetics profile suggests good lead and efficiency of S. repanda with no toxicity risks. Finally, further in vivo experimental investigations can be promoted as probable candidates for various therapeutic functions, drug discovery and development.
New Pharmaceutical Salts of Trazodone
Authors: Jaśkowska Jolanta , Zaręba Przemysław , Drabczyk Anna , Kozak Agnieszka , Madura Izabela D. , Majka Zbigniew , Pindelska Edyta
Published: February 2021

New pharmaceutically acceptable salts of trazodone (trazodone hydrogen bromide and trazodone 1-hydroxy-2-naphthonic acid) for the treatment of central nervous system disorders are synthesized and described. Although trazodone salts are poorly crystalline, single-crystal X-ray diffraction data for trazodone 1-hydroxy-2-naphthonic acid were collected and analyzed as well as compared to the previously described crystal structure of commercially available trazodone hydrochloride. The powder samples of all new salts were characterized by Fourier transform infrared spectroscopy, X-ray diffraction and 13C solid-state nuclear magnetic resonance spectroscopy. Spectroscopic studies were supported by gauge including projector augmented wave (GIPAW) calculations of carbon chemical shielding constants. The main goal of our research was to find salts with better physicochemical properties and to make an attempt to associate them with both the anion structure and the most prominent interactions exhibited by the protonated trazodone cation. The dissolution profiles of trazodone from tablets prepared from various salts with lactose monohydrate were investigated. The studies revealed that salts with simple anions show a fast release of the drug while the presence of more complex anion, more strongly interacting with the cation, effects a slow-release profile of the active substance and can be used for the preparation of the tables with a delay or prolonged mode of action.
Green Synthesis of Multifunctional Carbon Dots with Antibacterial Activities
Authors: Saravanan Arumugam , Maruthapandi Moorthy , Das Poushali , Luong John H. T. , Gedanken Aharon
Published: February 2021

Carbon dots (CDs) were obtained from medicinal turmeric leaves (Curcuma longa) by a facile one-step hydrothermal method and evaluated for their bactericidal activities against two gram-negative; Escherichia coli, Klebsiella pneumoniae, and two gram-positive counterparts; Staphylococcus aureus, S. epidermidis. The CDs exhibited spherical shapes with a mean size of 2.6 nm. The fluorescence spectra of CDs revealed intense fluorescence at λex/em = 362/429 nm with a bright blue color in an aqueous solution. The CDs showed strong photostability under various environmental conditions (pH, salt, and UV-radiation). The complete bactericidal potency of CDs was 0.25 mg/mL for E.coli and S. aureus after 8 h of exposure, while for K. pneumoniae, and S. epidermidis, the CDs at 0.5 mg/mL good antibacterial effect within 8 h and complete eradication after 24 h of exposure is observed. The release of reactive oxygen species played a crucial role in the death of the bacterial cell. The present study provides a strategy for the preparation of CDs from a medicinal plant and their potential antibacterial activities against four common contagious pathogens.
3D Printing of PDMS-Like Polymer Nanocomposites with Enhanced Thermal Conductivity: Boron Nitride Based Photocuring System
Authors: Pezzana Lorenzo , Riccucci Giacomo , Spriano Silvia , Battegazzore Daniele , Sangermano Marco , Chiappone Annalisa
Published: February 2021

This study demonstrates the possibility of forming 3D structures with enhanced thermal conductivity (k) by vat printing a silicone–acrylate based nanocomposite. Polydimethylsiloxane (PDSM) represent a common silicone-based polymer used in several applications from electronics to microfluidics. Unfortunately, the k value of the polymer is low, so a composite is required to be formed in order to increase its thermal conductivity. Several types of fillers are available to reach this result. In this study, boron nitride (BN) nanoparticles were used to increase the thermal conductivity of a PDMS-like photocurable matrix. A digital light processing (DLP) system was employed to form complex structures. The viscosity of the formulation was firstly investigated; photorheology and attenuate total reflection Fourier-transform infrared spectroscopy (ATR-FTIR) analyses were done to check the reactivity of the system that resulted as suitable for DLP printing. Mechanical and thermal analyses were performed on printed samples through dynamic mechanical thermal analysis (DMTA) and tensile tests, revealing a positive effect of the BN nanoparticles. Morphological characterization was performed by scanning electron microscopy (SEM). Finally, thermal analysis demonstrated that the thermal conductivity of the material was improved, maintaining the possibility of producing 3D printable formulations.
Preparation and Application of Fe-N Co-Doped GNR@CNT Cathode Oxygen Reduction Reaction Catalyst in Microbial Fuel Cells
Authors: Zhang Man , Ma Zhaokun , Song Huaihe
Published: February 2021

Through one-step pyrolysis, non-noble-metal oxygen reduction reaction (ORR) electrocatalysts were constructed from ferric trichloride, melamine, and graphene nanoribbon@carbon nanotube (GNR@CNT), in which a portion of the multiwall carbon nanotube is unwrapped/unzipped radially, and thus graphene nanoribbon is exposed. In this study, Fe-N/GNR@CNT materials were used as an air-cathode electrocatalyst in microbial fuel cells (MFCs) for the first time. The Fe-N/C shows similar power generation ability to commercial Pt/C, and its electron transfer number is 3.57, indicating that the ORR process primarily occurs with 4-electron. Fe species, pyridinic-N, graphitic-N, and oxygen-containing groups existing in GNR@CNT frameworks are likely to endow the electrocatalysts with good ORR performance, suggesting that a GNR@CNT-based carbon supporter would be a good candidate for the non-precious metal catalyst to replace Pt-based precious metal.
Inorganic Nanocarriers for Encapsulation of Natural Antimicrobial Compounds for Potential Food Packaging Application: A Comparative Study
Authors: Gulin-Sarfraz Tina , Kalantzopoulos Georgios , Kvalvåg Pettersen Marit , Wold Åsli Anette , Tho Ingunn , Axelsson Lars , Sarfraz Jawad
Published: February 2021

Design and development of novel inorganic nanocarriers for encapsulation of natural antimicrobial substances for food packaging applications have received great interest during the last years. Natural nanoclays are the most investigated nanocarriers and recently interest has also grown in the synthetically produced porous silica particles. However, these different carrier matrices have not been compared in terms of their loading capability and subsequent release. In this study, the feasibility of porous silica particles (with different pore structures and/or surface functionalities) and commercially available nanoclays were evaluated as encapsulation matrices. Two well-studied antimicrobial substances, thymol and curcumin, were chosen as volatile and non-volatile model compounds, respectively. The encapsulation efficiency, and the subsequent dispersibility and release, of these substances differed significantly among the nanocarriers. Encapsulation of the volatile compound highly depends on the inner surface area, i.e., the protective pore environment, and an optimal nanocarrier can protect the encapsulated thymol from volatilization. For the non-volatile compound, only the release rate and dispersibility are affected by the pore structure. Further, water-activated release of the volatile compound was demonstrated and exhibited good antimicrobial efficacy in the vapor phase against Staphylococcus aureus. This comparative study can provide a base for selecting the right nanocarrier aimed at a specific food packaging application. No nanocarrier can be considered as a universally applicable one.
Polarization-Independent Circulator Based on Composite Rod of Ferrite and Plasma in Photonic Crystal Structure
Authors: Lin Mi , Fu Lixin , Ahmed Shakeel , Wang Qiong , Zheng Yaoxian , Liang Zixian , Ouyang Zhengbiao
Published: February 2021

We propose a type of polarization-independent circulator based on a composite rod of ferrite and plasma materials in a two-dimensional photonic crystal (PhC) slab. Only one composite rod was set at the center of the structure to provide circulation for both TE- and TM-polarized waves. Additionally, to improve the performance of the circulator, three additional rods were inserted to improve the coupling condition between the center magneto-optical microcavity and the corresponding waveguides. Finite element method was used to calculate the characteristics of the structure and the Nelder–Mead optimization method was employed to obtain the optimum parameters. The results show that a low insertion loss (~0.22 dB) and high isolation (~14 dB) can be achieved in our structure for waves of both TE and TM polarizations. The idea presented here may be useful for designing compact polarization devices in large-scale integrated photonic circuits.
Sublingual Immunotherapy: How Sublingual Allergen Administration Heals Allergic Diseases; Current Perspective about the Mode of Action
Authors: Gotoh Minoru , Kaminuma Osamu
Published: February 2021

Owing to the successful application of sublingual immunotherapy (SLIT), allergen immunotherapy (AIT) has become one of the leading treatments for allergic diseases. Similar to the case with other AITs, such as subcutaneous and oral immunotherapies, not only the alleviation of allergic symptoms, but also the curing of the diseases can be expected in patients undergoing SLIT. However, how and why such strong efficacy is obtained by SLIT, in which allergens are simply administered under the tongue, is not clearly known. Various potential mechanisms, including the induction of blocking antibodies, T cell tolerance, regulatory B and T cells, CD103-CD11b+ classical dendritic cells, and CD206+ macrophages, and the reduction of innate lymphoid cells, mast cells, and basophils, have been suggested. Recently, through a comparative analysis between high- and non-responder patients of SLIT, we have successfully proposed several novel mechanisms. Here, we introduce our recent findings and summarize the current understanding of the mechanisms underlying the strong efficacy of SLIT.
Single Donor FMT Reverses Microbial/Immune Dysbiosis and Induces Clinical Remission in a Rat Model of Acute Colitis
Authors: Adamkova Petra , Hradicka Petra , Gancarcikova Sona , Kassayova Monika , Ambro Lubos , Bertkova Izabela , Maronek Martin , Farkasova Iannaccone Silvia , Demeckova Vlasta
Published: February 2021

Deviation in the gut microbial composition is involved in various pathologies, including inflammatory bowel disease (IBD). Faecal microbiota transplant (FMT) can act as a promising approach to treat IBD by which changes in microbiome can be reversed and homeostasis restored. Therefore, the aim of this study was to investigate the effect of FMT on the remission of acute inflammatory response using dextran sulfate sodium (DSS)-induced rat colitis model. Faecal microbial communities were analysed using the 16S rRNA approach, and clinical manifestations together with histological/haematological/biochemical/immunological analyses were assessed. Our study demonstrated significant shifts in the dominant species of microbiota under inflammatory conditions induced by DSS and evident restoration effect of FMT treatment on microbial composition. These faecal microbial alterations in FMT-treated rats led to a relative restoration of colon length, and a significant decrease in both epithelium damage and disease severity, which was reflected in lower serum pro-inflammatory cytokine levels. Haematological/biochemical parameters in DSS-treated animals showed signs of anaemia with a significant reduction in red blood cell count together with increasing levels of total bilirubin, creatinine and phosphorus suggesting potential protective effect of FMT. These results support FMT as a valuable therapeutic strategy to control inflammation during acute colitis.
Characterization of Used Lubricant Oil in a Latin-American Medium-Size City and Analysis of Options for Its Regeneration
Authors: Sánchez-Alvarracín Carlos , Criollo-Bravo Jessica , Albuja-Arias Daniela , García-Ávila Fernando , Pelaez-Samaniego M.
Published: February 2021

Petroleum-derived products, such as lubricant oils, are non-renewable resources that, after use, must be collected and processed properly to avoid negative environmental impacts. A circular economy of used oils requires the re-refining and reuse of the same. Similar to most countries in Latin America, the management of used oils in Ecuador is still incipient and few cities collect and treat this material properly. In Cuenca, the ETAPA company collects ~1344 t/year of used oils, which are subjected to pretreatment operations prior to their use as fuel in a cement factory. However, combustion generates polluting gases and disallows the adding of value to the used oils. The lack of studies on the characterization and methods utilized for recovering used oils under the conditions found in medium-size Latin-American cities (e.g., Cuenca), alongside a lack of government policies, have hindered the adoption of re-refining operations. The objective of this work is to characterize the used lubricant oils in Cuenca, to compare them with the properties of used oils from other countries, and to suggest some re-refining technologies for oils with similar properties. Used oil samples were collected from mechanic shops and car-lubricating shops for characterization. Its physicochemical properties and metal contents are comparable to the used oils in other countries globally. Specifically, the flash point, kinematic viscosity, TBN, and concentrations of Zn, Cd, and Mg are similar to the properties of used oils in Iraq, Egypt, and the United Arab Emirates. Based on these results, the best re-refining option for used oils in Cuenca is extraction with solvents in which sedimentation and dehydration (already conducted in Cuenca) is followed by a solvent reaction process, a vacuum distillation process, a finishing process with bentonite, and a final filtration step.
Sub-Auroral, Mid-Latitude, and Low-Latitude Troughs during Severe Geomagnetic Storms
Authors: Karpachev Alexander
Published: February 2021

The dynamics of ionospheric troughs during intense geomagnetic storms is considered in this paper. The study is based on electron density measurements at CHAMP satellite altitudes of 405–465 km in the period from 2000 to 2002. A detailed analysis of four storms with Kp from 5+ to 9− is presented. Three troughs were identified: sub-auroral, mid-latitude, and low-latitude. The sub-auroral trough is usually defined as the main ionospheric trough (MIT). The mid-latitude trough is observed equatorward of the MIT and is associated with the magnetospheric ring current; therefore, it is named the ring ionospheric trough (RIT). The RIT appears at the beginning of the storm recovery phase at geomagnetic latitudes of 40–45° GMLat (L = 1.75–2.0) and exists, for a long time, at the late stage of the recovery phase at latitudes of the residual ring current 50–55° GMLat (L ~ 2.5–3.0). The low-latitude trough (LLT) is discovered for the first time. It forms only during great storms at the latitudes of the internal radiation belt (IRB), 34–45° GMLat (L = 1.45–2.0). The LLT’s lowest latitude of 34° GMLat was recorded in the night sector (2–3 LT). The occurrence probability and position of the RIT and LLT depend on the hemisphere and longitude.
Development of an Automated Minimum Foot Clearance Measurement System: Proof of Principle
Authors: Delfi Ghazaleh , Kamachi Megan , Dutta Tilak
Published: February 2021

Over half of older adult falls are caused by tripping. Many of these trips are likely due to obstacles present on walkways that put older adults or other individuals with low foot clearance at risk. Yet, Minimum Foot Clearance (MFC) values have not been measured in real-world settings and existing methods make it difficult to do so. In this paper, we present the Minimum Foot Clearance Estimation (MFCE) system that includes a device for collecting calibrated video data from pedestrians on outdoor walkways and a computer vision algorithm for estimating MFC values for these individuals. This system is designed to be positioned at ground level next to a walkway to efficiently collect sagittal plane videos of many pedestrians’ feet, which is then processed offline to obtain MFC estimates. Five-hundred frames of video data collected from 50 different pedestrians was used to train (370 frames) and test (130 frames) a convolutional neural network. Finally, data from 10 pedestrians was analyzed manually by three raters and compared to the results of the network. The footwear detection network had an Intersection over Union of 85% and was able to find the bottom of a segmented shoe with a 3-pixel average error. Root Mean Squared (RMS) errors for the manual and automated methods for estimating MFC values were 2.32 mm, and 3.70 mm, respectively. Future work will compare the accuracy of the MFCE system to a gold standard motion capture system and the system will be used to estimate the distribution of MFC values for the population.
Gradiometer Using Separated Diamond Quantum Magnetometers
Authors: Masuyama Yuta , Suzuki Katsumi , Hekizono Akira , Iwanami Mitsuyasu , Hatano Mutsuko , Iwasaki Takayuki , Ohshima Takeshi
Published: February 2021

The negatively charged nitrogen-vacancy (NV) center in diamonds is known as the spin defect and using its electron spin, magnetometry can be realized even at room temperature with extremely high sensitivity as well as a high dynamic range. However, a magnetically shielded enclosure is usually required to sense weak magnetic fields because environmental magnetic field noises can disturb high sensitivity measurements. Here, we fabricated a gradiometer with variable sensor length that works at room temperature using a pair of diamond samples containing negatively charged NV centers. Each diamond is attached to an optical fiber to enable free sensor placement. Without any magnetically shielding, our gradiometer realizes a magnetic noise spectrum comparable to that of a three-layer magnetically shielded enclosure, reducing the noises at the low-frequency range below 1 Hz as well as at the frequency of 50 Hz (power line frequency) and its harmonics. These results indicate the potential of highly sensitive magnetic sensing by the gradiometer using the NV center for applications in noisy environments such as outdoor and in vehicles.
Fluid–Structure Coupling Effects in a Dual U-Tube Coriolis Mass Flow Meter
Authors: Hu Yuh-Chung , Chen Zen-Yu , Chang Pei-Zen
Published: February 2021

Coriolis mass flowmeters are highly customized products involving high-degree fluid-structure coupling dynamics and high-precision manufacture. The typical delay from from order to shipment is at least 4 months. This paper presents some important design considerations through simulation and experiments, so as to provide manufacturers with a more time-efficient product design and manufacture process. This paper aims at simulating the fluid-structure coupling dynamics of a dual U-tube Coriolis mass flowmeter through the COMSOL simulation package. The simulation results are experimentally validated using a dual U-tube CMF manufactured by Yokogawa Co., Ltd. in a TAF certified flow testing factory provided by FineTek Co., Ltd. Some important design considerations are drawn from simulation and experiment. The zero drift will occur when the dual U-tube structure is unbalanced and therefore the dynamic balance is very important in the manufacturing of dual U-tube CMF. The fluid viscosity can be determined from the driving current of the voice coil actuator or the pressure loss between the inlet and outlet of CMF. Finally, the authors develop a simulation application based on COMSOL’s development platform. Users can quickly evaluate their design through by using this application. The present application can significantly shorten product design and manufacturing time.
Efficient Wind Speed Forecasting for Resource-Constrained Sensor Devices
Authors: Herrería-Alonso Sergio , Suárez-González Andrés , Rodríguez-Pérez Miguel , Rodríguez-Rubio Raúl F. , López-García Cándido
Published: February 2021

Wind energy harvesting technology is one of the most popular power sources for wireless sensor networks. However, given its irregular nature, wind energy availability experiences significant variations and, therefore, wind-powered devices need reliable forecasting models to effectively adjust their energy consumption to the dynamics of energy harvesting. On the other hand, resource-constrained devices with limited hardware capacities (such as sensor nodes) must resort to forecasting schemes of low complexity for their predictions in order to avoid squandering their scarce power and computing capabilities. In this paper, we present a new efficient ARIMA-based forecasting model for predicting wind speed at short-term horizons. The performance results obtained using real data sets show that the proposed ARIMA model can be an excellent choice for wind-powered sensor nodes due to its potential for achieving accurate enough predictions with very low computational burden and memory overhead. In addition, it is very simple to setup, since it can dynamically adapt to varying wind conditions and locations without requiring any particular reconfiguration or previous data training phase for each different scenario.
Use of Multiple Bacteriophage-Based Structural Color Sensors to Improve Accuracy for Discrimination of Geographical Origins of Agricultural Products
Authors: Seol Daun , Jang Daeil , Cha Kyungjoon , Oh Jin-Woo , Chung Hoeil
Published: February 2021

A single M13 bacteriophage color sensor was previously utilized for discriminating the geographical origins of agricultural products (garlic, onion, and perilla). The resulting discrimination accuracy was acceptable, ranging from 88.6% to 94.0%. To improve the accuracy further, the use of three separate M13 bacteriophage color sensors containing different amino acid residues providing unique individual color changes (Wild sensor: glutamic acid (E)-glycine (G)-aspartic acid (D), WHW sensor: tryptophan (W)-histidine (H)-tryptophan (W), 4E sensor: four repeating glutamic acids (E)) was proposed. This study was driven by the possibility of enhancing sample discrimination by combining mutually characteristic and complimentary RGB signals obtained from each color sensor, which resulted from dissimilar interactions of sample odors with the employed color sensors. When each color sensor was used individually, the discrimination accuracy based on support vector machine (SVM) ranged from 91.8–94.0%, 88.6–90.3%, and 89.8–92.1% for garlic, onion, and perilla samples, respectively. Accuracy improved to 98.0%, 97.5%, and 97.1%, respectively, by integrating all of the RGB signals acquired from the three color sensors. Therefore, the proposed strategy was effective for improving sample discriminability. To further examine the dissimilar responses of each color sensor to odor molecules, typical odor components in the samples (allyl disulfide, allyl methyl disulfide, and perillaldehyde) were measured using each color sensor, and differences in RGB signals were analyzed.
Comparison of Femtosecond Laser-Assisted and Ultrasound-Assisted Cataract Surgery with Focus on Endothelial Analysis
Authors: Schroeter Anna , Kropp Martina , Cvejic Zeljka , Thumann Gabriele , Pajic Bojan
Published: February 2021

Femtosecond laser-assisted cataract surgery has the potential to make critical steps of cataract surgery easier and safer, and reduce endothelial cell loss, thus, improving postoperative outcomes. This study compared FLACS with the conventional method in terms of endothelial cells behavior, clinical outcomes, and capsulotomy precision. Methods: In a single-center, randomized controlled study, 130 patients with cataracta senilis received FLACS or conventional cataract surgery. Results: A significant endothelial cell loss was observed postoperatively, compared to the preoperative values in both groups. The endothelial cell counts was significantly better in the FLACS group in cataract grade 2 (p = 0.048) patients, compared to conventionally at 4 weeks. The effective phaco time was notably shorter in grade 2 of the FLACS group (p = 0.007) compared to the conventional. However, no statistically significant differences were found for the whole sample, including all cataract grades, due to the overall cataract density in the FLACS group being significantly higher (2.60 ± 0.58, p < 0.001) as compared to conventional methods (2.23 ± 0.42). Conclusions: Low energy FLACS provides a better result compared to endothelial cell loss, size, and shape variations, as well as in effective phaco time within certain cataract grade subgroups. A complete comparison between two groups was not possible because of the higher cataract grade in the FLACS. FLACS displayed a positive effect on endothelial cell preservation and was proven to be much more precise.
A FOD Detection Approach on Millimeter-Wave Radar Sensors Based on Optimal VMD and SVDD
Authors: Zhong Jun , Gou Xin , Shu Qin , Liu Xing , Zeng Qi
Published: February 2021

Foreign object debris (FOD) on airport runways can cause serious accidents and huge economic losses. FOD detection systems based on millimeter-wave (MMW) radar sensors have the advantages of higher range resolution and lower power consumption. However, it is difficult for traditional FOD detection methods to detect and distinguish weak signals of targets from strong ground clutter. To solve this problem, this paper proposes a new FOD detection approach based on optimized variational mode decomposition (VMD) and support vector data description (SVDD). This approach utilizes SVDD as a classifier to distinguish FOD signals from clutter signals. More importantly, the VMD optimized by whale optimization algorithm (WOA) is used to improve the accuracy and stability of the classifier. The results from both the simulation and field case show the excellent FOD detection performance of the proposed VMD-SVDD method.
Characterisation of Textile Embedded Electrodes for Use in a Neonatal Smart Mattress Electrocardiography System
Authors: Dore Henry , Aviles-Espinosa Rodrigo , Luo Zhenhua , Anton Oana , Rabe Heike , Rendon-Morales Elizabeth
Published: February 2021

Heart rate monitoring is the predominant quantitative health indicator of a newborn in the delivery room. A rapid and accurate heart rate measurement is vital during the first minutes after birth. Clinical recommendations suggest that electrocardiogram (ECG) monitoring should be widely adopted in the neonatal intensive care unit to reduce infant mortality and improve long term health outcomes in births that require intervention. Novel non-contact electrocardiogram sensors can reduce the time from birth to heart rate reading as well as providing unobtrusive and continuous monitoring during intervention. In this work we report the design and development of a solution to provide high resolution, real time electrocardiogram data to the clinicians within the delivery room using non-contact electric potential sensors embedded in a neonatal intensive care unit mattress. A real-time high-resolution electrocardiogram acquisition solution based on a low power embedded system was developed and textile embedded electrodes were fabricated and characterised. Proof of concept tests were carried out on simulated and human cardiac signals, producing electrocardiograms suitable for the calculation of heart rate having an accuracy within ±1 beat per minute using a test ECG signal, ECG recordings from a human volunteer with a correlation coefficient of ~ 87% proved accurate beat to beat morphology reproduction of the waveform without morphological alterations and a time from application to heart rate display below 6 s. This provides evidence that flexible non-contact textile-based electrodes can be embedded in wearable devices for assisting births through heart rate monitoring and serves as a proof of concept for a complete neonate electrocardiogram monitoring system.
Utilization of Electrical Impedance Spectroscopy and Image Classification for Non-Invasive Early Assessment of Meat Freshness
Authors: Huh Sooin , Kim Hye-Jin , Lee Seungah , Cho Jinwoo , Jang Aera , Bae Joonsung
Published: February 2021

This study presents a system for assessing the freshness of meat with electrical impedance spectroscopy (EIS) in the frequency range of 125 Hz to 128 kHz combined with an image classifier for non-destructive and low-cost applications. The freshness standard is established by measuring the aerobic plate count (APC), 2-thiobarbituric acid reactive substances (TBARS), and composition analysis (crude fat, crude protein, and moisture) values of the microbiological detection to represent the correlation between EIS and meat freshness. The EIS and images of meat are combined to predict the freshness with the Adaboost classification and gradient boosting regression algorithms. As a result, when the elapsed time of beef storage for 48 h is classified into three classes, the time prediction accuracy is up to 85% compared to prediction accuracy of 56.7% when only images are used without EIS information. Significantly, the relative standard deviation (RSD) of APC and TBARS value predictions with EIS and images datum achieves 0.890 and 0.678, respectively.
Improved Action Recognition with Separable Spatio-Temporal Attention Using Alternative Skeletal and Video Pre-Processing
Authors: Climent-Pérez Pau , Florez-Revuelta Francisco
Published: February 2021

The potential benefits of recognising activities of daily living from video for active and assisted living have yet to be fully untapped. These technologies can be used for behaviour understanding, and lifelogging for caregivers and end users alike. The recent publication of realistic datasets for this purpose, such as the Toyota Smarthomes dataset, calls for pushing forward the efforts to improve action recognition. Using the separable spatio-temporal attention network proposed in the literature, this paper introduces a view-invariant normalisation of skeletal pose data and full activity crops for RGB data, which improve the baseline results by 9.5% (on the cross-subject experiments), outperforming state-of-the-art techniques in this field when using the original unmodified skeletal data in dataset. Our code and data are available online.
A Novel Real-Time MATLAB/Simulink/LEGO EV3 Platform for Academic Use in Robotics and Computer Science
Authors: Montes Nicolas , Rosillo Nuria , Mora Marta C. , Hilario Lucia
Published: February 2021

Over the last years, mobile robot platforms are having a key role in education worldwide. Among others, LEGO Robots and MATLAB/Simulink are being used mainly in universities to improve the teaching experience. Most LEGO systems used in the literature are based on NXT, as the EV3 version is relatively recent. In contrast to the previous versions, the EV3 allows the development of real-time applications for teaching a wide variety of subjects as well as conducting research experiments. The goal of the research presented in this paper was to develop and validate a novel real-time educational platform based on the MATLAB/Simulink package and the LEGO EV3 brick for academic use in the fields of robotics and computer science. The proposed framework is tested here in different university teaching situations and several case studies are presented in the form of interactive projects developed by students. Without loss of generality, the platform is used for testing different robot path planning algorithms. Classical algorithms like rapidly-exploring random trees or artificial potential fields, developed by robotics researchers, are tested by bachelor students, since the code is freely available on the Internet. Furthermore, recent path planning algorithms developed by the authors are also tested in the platform with the aim of detecting the limits of its applicability. The restrictions and advantages of the proposed platform are discussed in order to enlighten future educational applications.
Density Distribution Maps: A Novel Tool for Subcellular Distribution Analysis and Quantitative Biomedical Imaging
Authors: De Santis Ilaria , Zanoni Michele , Arienti Chiara , Bevilacqua Alessandro , Tesei Anna
Published: February 2021

Subcellular spatial location is an essential descriptor of molecules biological function. Presently, super-resolution microscopy techniques enable quantification of subcellular objects distribution in fluorescence images, but they rely on instrumentation, tools and expertise not constituting a default for most of laboratories. We propose a method that allows resolving subcellular structures location by reinforcing each single pixel position with the information from surroundings. Although designed for entry-level laboratory equipment with common resolution powers, our method is independent from imaging device resolution, and thus can benefit also super-resolution microscopy. The approach permits to generate density distribution maps (DDMs) informative of both objects’ absolute location and self-relative displacement, thus practically reducing location uncertainty and increasing the accuracy of signal mapping. This work proves the capability of the DDMs to: (a) improve the informativeness of spatial distributions; (b) empower subcellular molecules distributions analysis; (c) extend their applicability beyond mere spatial object mapping. Finally, the possibility of enhancing or even disclosing latent distributions can concretely speed-up routine, large-scale and follow-up experiments, besides representing a benefit for all spatial distribution studies, independently of the image acquisition resolution. DDMaker, a Software endowed with a user-friendly Graphical User Interface (GUI), is also provided to support users in DDMs creation.
T1K+: A Database for Benchmarking Color Texture Classification and Retrieval Methods
Authors: Cusano Claudio , Napoletano Paolo , Schettini Raimondo
Published: February 2021

In this paper we present T1K+, a very large, heterogeneous database of high-quality texture images acquired under variable conditions. T1K+ contains 1129 classes of textures ranging from natural subjects to food, textile samples, construction materials, etc. T1K+ allows the design of experiments especially aimed at understanding the specific issues related to texture classification and retrieval. To help the exploration of the database, all the 1129 classes are hierarchically organized in 5 thematic categories and 266 sub-categories. To complete our study, we present an evaluation of hand-crafted and learned visual descriptors in supervised texture classification tasks.