bluuebunny/crossref_metadata_2025 huggingface dataset:
GATA2 deficiency with early-onset interstitial pneumonia
Authors: Sugiura Yuriko , Ando Takahiro , Urushiyama Hirokazu , Mitani Akihisa , Tanaka Goh , Kashimada Kenichi , Morio Tomohiro , Kage Hidenori
Published: April 2024

Background
GATA2 deficiency is a rare disease caused by a germline heterozygous mutation in the GATA2 gene. This mutation is known to cause a decrease in hematopoietic stem cells and a decrease in monocytes, dendritic cells, NK cells, and B cells, leading to various diseases such as hematological, infectious, and respiratory diseases.
Case presentation:
In this study, we present a case in which a patient in her 20s developed sensorineural hearing loss, schizophrenia, and interstitial pneumonia, leading to the diagnosis of GATA2 deficiency. The patient later developed pulmonary hypertension as the interstitial pneumonia progressed.
Conclusions
Early-onset interstitial pneumonia may be a rare phenotype of GATA2 deficiency.
High-resolution full-field structural microscopy of the voltage-induced filament formation in VO2-based neuromorphic devices
Authors: Kisiel Elliot , Salev Pavel , Poudyal Ishwor , Carneiro Fellipe , Rodolakis Fanny , Zhang Zhan , Shpyrko Oleg , Schuller Ivan , Islam Zahir , Frano Alex
Published: April 2024

Neuromorphic functions in memristive devices, linked to electrically induced resistive switching to form conductive pathways, could be made more efficient by insights into filament formation at micro- and mesoscopic levels. Despite extensive research on VO2, a key material for its filament formation, local operando structural measurements are highly challenging and often involve destructive specimen preparation and long rastering time, which greatly limits the scope of experimental studies. Utilizing dark-field X-ray microscopy (DFXM), a novel full-field X-ray imaging technique, we explored structural signatures of the filament formation process operando in VO2 devices. Our DFXM experiments display that rutile filaments contain isolated monoclinic clusters, indicating structural non-uniformity of the filament. We also show that the formation of the rutile phase beneath device electrodes precedes filament development, with filament paths then guided by nucleation sites within the device. Finally, we observed a new medium-term memory mechanism in VO2 mediated by sites that tend to switch at significantly lower voltages after electrical cycling, a tendency that persists through brief cooling. High spatial resolution, large field-of-view, structure selectivity, and fast signal acquisition of DFXM enabled first-of-their-kind measurements providing unprecedented insight into subtle structural features of the filamentary channel and surrounding regions during voltage cycling.
Enhancing Thermostability of Bacillus licheniformis Lipase with LEA Peptide Co-expression System.
Authors: Almansoori Ammar Khazaal Kadhim , Yu Kang Siang , Mohamed Faisal , Ikeno Shinya , Patil Rajesh B. , G Ropón-Palacios , Rahim Rashidah Abdul
Published: April 2024

Heterozygous protein expression in E. coli facilitates high yield and quality. However, the challenges of protein instability due to environmental stress are still an issue that affects the activity of the protein produced. In this study, the improvement of protein thermostability was done using a peptide co-expression system. The developed system exploited the usefulness of Late Abundant Embryogenesis (LEA) proteins to protect proteins from damage. Recombinant lipase from Bacillus licheniformis was expressed along with the LEA-like peptide, whose design was inspired by the 11 repetitive amino acid sequences of the LEA protein. In total, four LEA-like peptide co-expression systems were assessed. The evaluation of improvements in protein thermostability was conducted using a standard lipase assay. The purified lipase was challenged at 45 °C, a higher temperature than its optimal temperature. Two-fold lipase activity was recorded from the protein co-expressed with the LEA-II-like peptide. Based on amino acid sequence comparison, LEA-II has the advantage of containing more polar residues with several aliphatic amino acids, which may improve LipAB.licheniformis-LEA II complex stability at higher temperatures. Next, molecular docking and molecular dynamic simulation were employed to analyze the stability of the lipase in the presence and absence of LEA II. The findings of the RMSD, MM-GBSA and related analyses showed that the LipAB.licheniformis-LEA II complexes have better stability than the LipAB.licheniformis alone, thus supporting the lipase assay. These findings successfully unravel the potential of the LEA-like peptide co-expression system as a novel approach to improve enzyme thermostability.
Implementation and Optimization of SpMV algorithm based on SW26010P many-core processor and stored in BCSR format
Authors: Ma Mengfei , Huang Xianqing , Xu Jiali , Jia Dongning
Published: April 2024

The irregular distribution of non-zero elements of large-scale sparse matrix leads to low data access efficiency caused by the unique architecture of the Sunway many-core processor, which brings great challenges to the efficient implementation of sparse matrix-vector multiplication (SpMV) computing by SW26010P many-core processor. To address this problem, a study of SpMV optimization strategies is carried out based on the SW26010P many-core processor. Firstly, we design a memorized data storage transformation strategy to transform the matrix in CSR storage format into BCSR storage. Secondly, the dynamic task scheduling method is introduced to the algorithm to realize the load balance between slave cores. Thirdly, the LDM memory is refined and designed, and the slave core dual cache strategy is optimized to further improve the performance. Finally, we selected a large number of representative sparse matrices from the Matrix Market for testing. The results show that the scheme has obviously speedup the processing procedure of sparse matrices with various sizes and sizes, and the master-slave speedup ratio can reach up to 38 times. The optimization method used in this paper has implications for other complex applications of the SW26010P many-core processor.
Effects of C-reactive protein and neutrophil to lymphocyte ratio on cognitive dysfunction after basal ganglia hemorrhage
Authors: Li Jing , Zhang Mei , Xue Min , Hu Pan-pan
Published: April 2024

Objective
To investigate the effects of C-reactive protein(CRP) and the neutrophils to lymphocytes ratio(NLR) on cognitive dysfunction after spontaneous basal ganglia hemorrhage.
Methods
263 patients with spontaneous basal ganglia cerebral hemorrhage admitted to our hospital from September 2021 to January 2024 were selected as the study objects.Cognitive function was assessed by the Montreal Cognitive Assessment Scale (MoCA) after six months and divided into cognitive dysfunction group and normal cognitive function group.The level of CRP and NLR were compared between the two groups.The correlation between the level and degree of cognitive impairment was analyzed, and the correlation factors of cognitive impairment in spontaneous basal ganglia hemorrhage were studied by single factor, ROC curve and Logistic regression analysis.
Results
Among 263 patients, 120 (45.63%) had cognitive impairment after basal ganglia hemorrhage.The CRP and NLR in the cognitive dysfunction group were significantly higher than those in the normal cognitive function group (P < 0.05).ROC curve analysis showed that National Institute of Health Stroke Scale(NIHSS) score, amount of bleeding, white blood cells(WBC), absolute neutrophil count(ANC), NLR and CRP were associated with cognitive impairment after spontaneous basal ganglia hemorrhage.The area under the curve(AUC) of NLR was 83.1%, and the CRP was 77.4%.The NLR and CRP were the optimal predictive variables,The optimal prediction thresholds of ROC analysis were 3.88 and 3.34.Logistic regression analysis found that after adjusting for confounding factors, NLR and CRP were still independently associated with cognitive impairment after basal ganglia hemorrhage (OR = 1.38,95%CI: 1.15–1.64, P < 0.001) and (OR = 1.42,95%CI: 1.19–1.85, P < 0.001).
Conclusion
The NLR and CRP in the acute stage of spontaneous basal ganglia hemorrhage were independently associated with cognitive dysfunction after 6 months, suggesting that NLR and CRP may be the important biomarkers for predicting cognitive dysfunction after spontaneous basal ganglia hemorrhage.
Association of different combination doses of remifentanil-propofol with transcranial motor-evoked potentials during skull base surgery
Authors: Hou Ruixue , Xiao Wei , Miao Fangfang , Yin Cheng , Jin Di , Duan Qingfang , Wang Tianlong
Published: April 2024

Background
Monitoring of transcranial electrical motor evoked potentials (TceMEPs) is widely used in neurosurgery. The association of different combination doses of remifentanil-propofol in total intravenous anesthesia (TIVA) with TceMEPs during surgery remains uncertain.
Methods
In this prospective observational study, consecutive patients (aged 18–65 years) who underwent skull base surgery under general anesthesia at our clinical center between April 2021 and April 2023 were included. All patients were anesthetised with propofol-remifentanil TIVA and maintained at a Bispectral Index of 40–60. The association between different combination doses of remifentanil-propofol and the change in TceMEP amplitude from baseline was assessed using a multivariable model adjusted for confounders and a response surface model. Besides, anesthetic dose, extubation time, pain score at 24h postoperatively and unexpected body movements during surgery were recorded.
Results
A total of 240 patients (mean age, 49.3 [SD, 12.1] years; 107 [44.6%] women) who underwent skull base surgery were included in this study. Our study showed that an increase in propofol dose was significantly associated with a constant increase in the Log of the change in TceMEP amplitude (β = 0.29 [95%CI: 0.01 to 0.58], p = 0.046) after adjustment. Increasing remifentanil was not associated with Log (change in TceMEP amplitude) (β = 0.33 [95%CI: -2.1 to 2.76], p = 0.79) after adjustment. In addition, through the response surface analysis, we found that when the propofol infusion was less than 2.96 mg/kg/h and the remifentanil infusion was greater than 0.24 µg/kg/min, the more the remifentanil infusion was, the less impact it had on the changes in TceMEP. When the propofol infusion was greater than 2.96 mg/kg/h, as the propofol infusion increased, it had a greater impact on the changes in TceMEP. Pearson’s test showed a correlation between propofol and remifentanil dose at BIS 40–60 (γ= -0.4637, p < 0.001).
Conclusions
In this study, propofol reduced TceMEP amplitude in a dose-dependent manner. Due to the synergistic interactions between propofol and remifentanil, remifentanil could reduce the amount of propofol at the same anesthesia depth, a propofol infusion rate less than 2.96mg/kg/h and a remifentanil rate greater than 0.24 µg/kg/min is recommended in neurosurgery requiring TceMEP monitoring.
Changes in sexual behavior among MSM during the spread of COVID-19 in China: results of an online survey
Authors: Lv Hang , Feng Yunlong , Huang Shanzi , Li Jiarun , Tang Weiming , Zhou Yi
Published: April 2024

Background
Sexual behavior drives the transmission of sexually transmitted infections, especially among men who have sex with men (MSM). This study aims to evaluate the sexual behavior changed among MSM during the COVID-19.
Methods
An online survey was conducted to collect socio-demographic, sexual behavioral, and HIV testing information before and during the COVID-19. Chi-square was used to determine the behavior differences before and during the COVID-19. We identified the factors associated with sexual behavior among MSM using logistic regression.
Results
Totally 506 MSM participated in the survey. Compared with participants who didn't reduce the number of sexual partners (193, 38.1%), participants who reduced sexual partners (313, 61.9%) had higher values of multiple sexual partners, causal sexual partners, used condoms with causal sexual partners, and sought sexual partners using apps. Participants who reduced the number of sexual partners than before COVID-19, reported having a higher proportion of causal sexual behavior (χ2 = 21.047, p < 0.001), which means engaged in casual sex in the last three months.
Conclusions
The lockdown measures significantly impacted the sexual behavior of MSM. After the epidemic is over, however, we need to increase health education for MSM to reduce their high-risk sexual behaviors and protect them from STDs.
Evaluation of a multiplex Real-time PCR kit for simultaneous diagnosis of Ureaplasma urealyticum and Ureaplasma parvum
Authors: Jiang Ni , Huang Ming-yao , Jiang Lie-jun , Tan Chun-yan , Mo Zhi-jiang , Zhou Ying , Huang Xue-mei
Published: April 2024

Background: The aim of the study was to evaluate the clinical performance of the newly commercial PCR Kit (RepoDx) for Ureaplasma urealyticum (UU) and Ureaplasma parvum (UP) detection.
Methods: A total of 572 genital tract swabs were tested. The kit performance for UU and UP detection was compared to that of Sanger sequencing, targeting specific regions within the UUR10_0680 and UP063 genes.
Results: The RepoDx PCR kit showed an overall agreement (accuracy) of 96.31% (95%CI = 0.9441-0.9770, kappa = 0.940) for UU/UP with sequencing, offering over 93% positive percent agreement (PPA) and negative percent agreement (NPA) for detecting UU and UP. However, NPA dropped significantly with Mycoplasma hominis (MH) co-infection [NPA (UU-, UP-, MH-) vs. NPA (UU-, UP-, MH+): 93.86% vs. 65.22%], suggesting MH might interfere with Repodx PCR kit, meriting further investigation due to the significantly lower prevalence of MH than Ureaplasma in this study.
Conclusions: Multiplex real-time PCR kit is a convenient method for the simultaneous detection of UU and UP. The overall agreement of the RepoDx PCR kit was comparable to that of the sequencing method.
99m Tc-Labelled Photoacoustic Imaging Probe for Detection of Bacterial Infection
Authors: Swann Rowan , Hernández-Valdés Daniel , Silva Luis Rafael , Marfatia Yusra Mahmood , El-Zaria Mohamed E. , Genady Afaf R. , Kwiecien Jacek M. , Valliant John F. , Sadeghi Saman
Published: April 2024

The development of a non-invasive infection-specific diagnostic probe holds the potential to vastly improve early-stage detection of infection, enabling precise therapeutic intervention and potentially reducing the incidence of antibiotic resistance. Towards this goal, a commercially available bacteria-targeting Zinc (II)-dipicolylamine (ZnDPA)-derived fluorophore, PSVue794, was assessed as a photoacoustic (PA) imaging probe (PIP). A radiolabeled version of the dye, [99mTc]Tc-PSVue794, was developed to facilitate quantitative biodistribution studies beyond optical imaging methods, which showed a target-to-non-target ratio of 10.1 ± 1.1, 12 hrs post-injection. The ability of the PIP to differentiate between bacterial infection, sterile inflammation, and healthy tissue in a mouse model, was then evaluated via PA imaging. The PA signal in sites of sterile inflammation (0.062 ± 0.012 a.u.) was not statistically different from that of the background (0.058 ± 0.006 a.u.). In contrast, high PA contrast was detected at sites of bacterial infection (0.176 ± 0.011 a.u.) as compared to background (0.081 ± 0.04 a.u., where P ≤ 0.03). This work demonstrates the potential of utilizing established fluorophores towards PAI and utilizing PAI as a modality in the distinction of bacterial infection from sites of sterile inflammation.
The Role of Landscape Design in Enhancing Environmental Sustainability and Human Well-being
Authors: Tongyun Wang , Wei Zhou , Fei Xu
Published: April 2024

This study employs qualitative research methods to examine the impact of landscape design on promoting environmental sustainability and improving human well-being. The researchers conducted face-to-face interviews with a total of six students and three teachers. Using purposive sampling, the study seeks to identify current issues and suggest remedies pertaining to landscape design. The investigation is guided by three objectives, and nine sub-questions have been formulated to ensure a thorough and comprehensive analysis. The study employs NVivo 14 software for data analysis, utilising coding techniques to identify prominent themes. The research seeks to explore the difficulties, suggest remedies, and contribute to the development of sustainable and harmonious environments, as seen from the viewpoints of both students and teachers. The main goals are to identify current issues related to landscape design, investigate possible solutions, and analyse emerging patterns from interviews. The study aims to clarify the importance of landscape design in establishing sustainable ecosystems and enhancing human well-being by analysing both the obstacles and the remedies. This study enhances our comprehension of the intricate characteristics of landscape design and its consequences for both ecological sustainability and the interaction between humans and the environment.
Time Series Mapping and Monitoring of Agroforestry Area in Yamunanagar District of Haryana State Using Geospatial
Authors: Babu Bojja Harish , Arya Sandeep , Kumar K. E. Mothi , Nanda Krishma
Published: April 2024

Diverse agroforestry practices are prevalent in different Agro-Climatic regions of India and occupies substantial area. In Northern India’s Indo-Gangetic plains, agroforestry activities with respect to (eucalyptus) Eucalyptus tereticornis and (poplar) Populus deltoides based practices are very dominant. These agroforestry systems not only satisfy the need for wood to Wood-based Industries, but also contribute significantly to employment generation and the reduction of atmospheric Carbon dioxide (CO2) vis-à-vis mitigating climate change. Mapping and monitoring agroforestry areas by using the LISS-III and LISS-IV Multispectral High Resolution Satellite Remote Sensing data in the Yamunanagar district of Haryana has been undertaken to develop an operational method in the present research. Supervised classification method was used for land use land cover analysis for the year 2010 and 2019 in which training sites for seven parameters viz, agroforestry (Poplar, Eucalyptus based), agriculture, plantations (Horticulture, Scrub plantations, miscellaneous plantations) water bodies, forest, buildups, riverbed areas were mapped and monitored. The maximum area was estimated under agroforestry systems i.e. 4.06 and 9.69 percent, which includes both poplar and eucalyptus based Agri-silviculture and boundary systems for the year 2010 and 2019 respectively. Agricultural land, forests and other plantations constitute about 73.56%, 11.08% and 1.96% in 2010 and 67.77%, 10.99%, 1.7% in the year 2019 respectively of total district area. The accuracy of the image classification was delineated based on the ground truth data collected from the Yamunanagar district by using GPS (Global Positioning System) and accuracy found in Agroforestry was 90%.
Casual relationship between 731 immunophenotypes and sepsis: A Bidirectional Two-sample mendelian randomization study
Authors: Jiang Daishan , Bian Tingting , Shen Yan , Yuan Xiaoyu , Yang Yang , Shen Yanbo , Huang Zhongwei
Published: April 2024

Background
The causal relationship between immune cell phenotypes and their interactions with sepsis remains partially understood, with several aspects subject to debate. Our objective was to bidirectionally investigate specific immune cell phenotypes and their association with sepsis.
Methods
We performed bidirectional Mendelian randomization (MR) analysis using publicly available genome-wide association study (GWAS) summary statistics to investigate the causal links between 731 immunophenotypes and sepsis. We conducted comprehensive sensitivity analyses to ensure robustness and consistency and assess for possible horizontal pleiotropy of our results.
Results
The analysis, adjusted for multiple comparisons using the Bonferroni method, revealed that increased levels of CD66b + + myeloid cells (Odds Ratio [OR] = 0.945, 95% Confidence Interval [CI]: 0.916–0.974, P = 0.0002, PBonferroni= 0.0089), BAFF-R on IgD- CD38br B cells (OR = 0.919, 95% CI: 0.873–0.966, P = 0.001, PBonferroni = 0.0365), and CD39 on CD39 + CD8br regulatory T cells (OR = 0.927, 95% CI: 0.890–0.966, P = 0.0003, PBonferroni = 0.0116) play a protective role against sepsis, as determined by the inverse variance weighted (IVW) method. Our findings did not reveal any significant impacts of sepsis on immunophenotypes.
Conclusions
This study highlights the potential protective roles of CD66b + + myeloid cells, BAFF-R on IgD- CD38br B cells, and CD39 on CD39 + CD8br regulatory T cells against sepsis. These insights advance our understanding of the immune system's interaction with sepsis risk and propose new avenues for immunotherapy-oriented interventions.
Adaptive Admittance Flexible Control Based on a Fuzzy Predictor for Active Suspension with Electrohydraulic Actuators
Authors: Yang Mengke , Liu Shuang , Zhao Dingxuan , Ding Honggang
Published: April 2024

This paper presents an adaptive admittance flexible control approach for a multi-axle heavy-duty wheeled vehicle (MHWV) equipped with an electrohydraulic actuator active suspension. The proposed method aims to enable flexible interaction control between the vehicle and uneven roads, enhancing the load-bearing stability and ride comfort of the MHWV over rough terrain. To reduce the effects of nonlinearity in the hydraulic system and uncertainties in the environmental stiffness on the force-tracking performance during interaction control, an adaptive fuzzy predictor (AFP) is proposed in this study for the nonlinear identification of the hydraulic suspension systems. The predictor is employed to estimate the nonlinear relationship between the output force of the hydraulic actuator and its relative displacement during vehicle-road interactions, thus enabling multistep-ahead prediction of the actuator output force. The Levenberg-Marquardt optimization algorithm is used to produce an adaptive admittance controller with precise force-tracking performance by optimizing and adaptively adjusting the admittance controller parameters based on the output force errors and the desired force within the prediction range. Finally, the validity of the AFP is confirmed on a three-axle heavy-duty wheeled experimental prototype (THWEP). The results of the vehicle experiments indicate that the proposed method has better force-tracking performance than does the conventional constant-parameter admittance controller. Thus, the ride comfort, load-bearing stability, and ability to retain the attitude of the THWEP are enhanced.
To assess the clinical effectiveness of unilateral biportal endoscopy (UBE) and uniportal endoscopy (UE) in the management of lumbar spinal stenosis.
Authors: 江 高 , 翔宇 孟
Published: April 2024

Purpose To assess the clinical effectiveness of unilateral biportal endoscopy (UBE) and uniportal endoscopy (UE) in the management of lumbar spinal stenosis.
Methods Retrospective analysis was done on the clinical records of 61 patients with lumbar spinal stenosis treated with UBE or UE in the minimally invasive spine surgery department of the Sixth Affiliated Hospital of Xinjiang Medical University between January 2023 and January 2024. The patients' average age was 66.4±12.5, and they included 24 males and 37 females. Using various surgical techniques, the patients were split into two groups: the UE group (33 cases) and the UBE group (28 cases). In order to assess the treatment scores, data on the two groups' operational times, intraoperative blood loss, visual analogue scales (VAS), and 0swestry Disability Index (0DI) were gathered and compared. The area of the dural sac and the angle of facet joint resection were determined based on preoperative and postoperative MRI and CT scans, and the problems were noted.
Results Every patient had a successful surgical procedure.The intraoperative blood loss in the UBE group was 79.8±17.2ml, and the operative time was 68.7±9.8min.The group's UE was 71.5±10.8min and 73.5±21.7ml, respectively. There was no statistically significant difference between the groups (p>0.05).The two groups' post-operative VAS and ODI scores were lower than their pre-operative scores and exhibited a persistent downward trend. No statistically significant differences were found between the groups (p>0.05) in the variance analysis of the repeated measurement design.At the most recent follow-up, the rate of good and good showed no statistical significance (P>0.05).The dural sac area was (103.25±35.16) mm2 in the UE group and (126.73±42.74) mm2 in the UBE group (P<0.02).In the UBE group, the angle of lateral facet arthrotomy was 77.92°±12.17°, but in the UE group, it was 95.48°±11.98° (P<0.000).
Conclusion Both UBE and UE have good short-term clinical efficacy in treating lumbar spinal stenosis; however, UBE has a better imaging decompression effect and can better preserve zygapophysial joint.
Role of salivary proteins on radiation-related caries onset in head and neck cancer patients treated with radiotherapy - a longitudinal study.
Authors: Agurto Maria Gonzalez , Bozorgi Sophie , Carpenter Guy , Ramirez Valeria , burke Mary , gutierrez Mario Felipe , Cordova Christian , Banerjee Avijit
Published: April 2024

Objective
Longitudinal assessment of the role of specific proteins on radiotherapy caries (RC) onset in head and neck cancer patients (HNC)up to one-year post intensity-modulated radiation therapy (IMRT).
Methods
Dental status/salivary protein data were obtained from 40 HNC patients pre-IMRT (T0), six months (T1) and 12 months (T2) post-IMRT (ethical approval/consent). DMFT and salivary parameters were quantified including flow rate, mucin 5B and 7, Immunoglobulin A (IgA), and cystatin S and α-amylase.
Results
45% patients had at least one carious lesion at T2, having a significant reduction in the number of remaining teeth (65% <21), salivary flow rate (<50%,) and, protein secretion (<0.05) post-IMRT. At T1 IgA concentration/secretion rate were associated with caries lesions (p<0.05). Finally, IgA and total protein concentration obtained at T1 could provide a predictive pattern (AUC 82.3%) for the patients more predisposed to developing RC at T2.
Conclusion
This study demonstrated the significant association of RC with salivary proteins in HNC patients treated with IMRT, revealing the potential role of salivary proteins in the early diagnosis of RC.
Clinical relevance: This research contributes to reveal salivary proteins association with RC, and its role in early diagnosis. Therefore, this could be the first step towards for personalized medicine approaches to improve this group quality of life (QoL).
Digital 2-year multidomain health interventions improve cognition and stabilize Alzheimer’s disease risk in at-risk adults (DC-MARVEL): A randomized controlled trial
Authors: Gray Michelle , Campitelli Anthony , Glenn Jordan , Gills Joshua , Jones Megan , Urbina Ray , Bryk Kelsey , Myers Jennifer , Paulson Sally , Kempkes Jenova , Helberg Katelyn
Published: April 2024

Alzheimer's disease and related dementias (ADRD) impose a substantial burden on quality of life among older adults, with healthcare costs totaling approximately $345 billion in 2023. Research suggests lifestyle-based interventions, such as health coaching (HC), are promising intervention strategies for reducing modifiable ADRD risk factors. In-person HC has demonstrated varying degrees of efficacy through behavioral modification strategies including personalized goal setting, education, and guidance. However, the effectiveness of a virtual HC program for reducing ADRD risk and modifying cognition among at-risk adults remains unexplored. The purpose of the Digital Cognitive Multidomain Alzheimer’s Risk Velocity (DC-MARVEL) randomized controlled clinical trial was to evaluate the effectiveness of a two-year virtual HC intervention and an enhanced virtual health education (HE) intervention among adults at-risk for ADRD. There were no significant differences between the HC intervention and HE in overall ADRD risk over time; however, a sub analysis of older adults (65+) revealed significant improvement in risk scores among HC participants. Both groups improved in several cognitive domains. Results of this study support the advantages of lifestyle-based interventions in mitigating ADRD risk. It also demonstrates the efficacy of both virtual HC and structured HE protocols to stabilize ADRD risk and promote improvements in cognition among at-risk adults.
T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing
Authors: Xiong Yulong , Zhang Zhenhao , Liu Shangyu , Shen Lishui , Zheng Lihui , Ding Ligang , Liu Limin , Wu Lingmin , Hu Zhicheng , Li Le , Hu Zhao , Zhang Zhuxin , Zhou Likun , Xu Mengtong , Yao Yan
Published: April 2024

Utilizing small interfering RNA (siRNA) for gene silencing presents a viable strategy for treating human diseases, including cardiovascular disorders. However, the strategic targeting and delivery of siRNA therapeutics to desired tissues or cell subtypes, followed by endosomal escape into the cytosol, remain challenging. Based on previous research, we identified interferon regulatory factor 1 (IRF1)-mediated macrophage pyroptosis as a potential therapeutic target for myocarditis. Herein, a T lymphocyte-macrophage hybrid membrane-coated zeolitic imidazolate framework-8 (ZIF-8) nano-delivery platform was fabricated for the precise conveyance of siRNA against IRF1 (siIRF1) to the pro-inflammatory M1 macrophages in myocarditis (siIRF1@ZIF@HM). The siIRF1-loaded ZIF-8 nanoparticle exhibited a high siRNA loading capacity and efficient endo-lysosomal escape ability. The application of hybrid membrane coating significantly improved M1 macrophage targeting both in vivo and in vitro. Delivery of siIRF1 effectively suppressed IRF1 expression and concomitantly inhibited pyroptosis in IFN-γ-stimulated macrophages. Consequently, the siIRF1 nanotherapeutic approach demonstrated the potential to attenuate myocardial inflammation and mitigate the progression of myocarditis. Our study reveals that the customized biomimetic nano-delivery system holds great prospects in the treatment of inflammatory diseases.
Psychophysiological effects of walking in forests and urban built environments with disparate road traffic noise exposure: study protocol of a randomized controlled trial
Authors: Schaupp Julia , Hediger Karin , Wunderli Jean-Marc , Schäffer Beat , Tobias Silvia , Kolecka Natalia , Bauer Nicole
Published: April 2024

Background
Stress is a widespread phenomenon and reality of everyday life, entailing negative consequences for physical and psychological wellbeing. Previous studies have indicated that exposure to greenspaces and nature-based interventions are promising approaches to reducing stress and promoting restoration. However, an increasing percentage of the population lives in urban regions with limited opportunities to spend time in greenspaces. In addition, urban settings typically feature increased levels of noise, which represents a major environmental stressor. Although various studies have compared the effects of exposure to greenspaces versus urban built environments, evidence of the effects of noise in this context is very limited. Psychophysiological benefits of exposure to greenspaces compared to urban built environments reported in earlier studies might be less (or at least not only) due to features of the greenspaces than to additional stressors, such as road traffic noise in the urban built environment. Hence, differences in the effects attributed to greenness in previous studies may also be due to potentially detrimental noise effects in comparison settings. This paper reports the study protocol for a randomized, controlled intervention study comparing the effects of walking in forest versus urban built environments, taking road traffic noise exposure during walks in the respective settings into account.
Methods
The protocol envisages a field study employing a pretest-posttest design to compare the effects of 30-minute walks in urban built environments and forests with different road traffic noise levels. Assessments will consist of self-reported measures, physiological data (salivary cortisol and skin conductance), an attention test, and noise, as well as greenness measurements. The outcomes will be restoration, stress, positive and negative affect, attention, rumination, and nature connectedness.
Discussion
The results will inform about the restorative effect of walking in general, of exposure to different types of environments, and to different noise levels in these sites. The study will provide insights into the benefits of walking and nature-based interventions, taking into account the potential detrimental effects of noise exposure. It will thus facilitate a better understanding of low-threshold interventions to prevent stress and foster wellbeing.
Trial registration:
ISRCTN48943261, https://doi.org/10.1186/ISRCTN48943261; Registered 23.11.2023.
Performance Analysis of Grid-Connected Photovoltaic Systems in Dhaya Algeria
Authors: Bouroumeid yassine , Jbilou Mokhtaria , BECHEKIR Seyf Eddine , Nemmich Said , Ghaitaoui Essama Ahmed , Brahami Mostefa
Published: April 2024

The escalating demand for electricity driven by population growth has strained Algeria's power stations to boost their output. With the significant decline in solar photovoltaic (SPV) electricity prices and the escalating tariffs on conventional electricity, there has been a growing interest in solar photovoltaic plants for electricity generation. Consequently, accurately evaluating the annual and monthly yield of SPV plants becomes crucial for designing and installing new facilities. This paper presents an assessment of a 12 MW grid-connected photovoltaic power plant situated in the Dhaya region of Sidi Bel Abbes, Algeria. Real-time observational data was collected from January 1st, 2023, to December 2023. Evaluated parameters include energy output, final yield, performance ratio (PR), among others. The power plant supplied 20780.67 MWh to the grid in 2023. The final yield (Yf) ranged from 3.25 to 5.88 kWh/kWp, the performance ratio (PR) varied from 79% to 89.71%, and the annual capacity factor was determined to be 19.44%. These parameters are compared with those obtained from simulations using PVsyst software and solar GIS-PV planner.
Effectiveness of primary care-based chronic disease management program on glycated hemoglobin levels
Authors: Kim Juan , Yun Il , Park Eun-Cheol , Ha Min Jin
Published: April 2024

Background: Diabetes is one of the most common causes of cardiovascular disease and has led to death over time. For better management of glycated hemoglobin levels, which is a well-known index in diagnosing diabetes, many countries have been launching chronic disease management programs. Therefore, this study aimed to evaluate the effectiveness of the primary care-based chronic disease management integrated pilot program (PCDMP) in controlling glycated hemoglobin (HbA1c) levels in Korea. Nation-wide data from the 2019–2021 Korea National Health and Nutrition Examination Survey were used.
Methods: We analyzed nationwide health examination data combined with various regional data sources. Using appropriate inclusion criteria for this study, a total of 13,901 individuals were suitable for the analysis. A generalized linear mixed model was applied to consider the clustered structure of the regional level data, where individual-level data, containing demographic characteristics and health-related information, were nested.
Results: Individuals living in areas with a low PCDMP participation (< 30.37%) had odds (95% CI, 1.08–1.82) of exhibiting glycated hemoglobin levels ≥ 6.5% greater than did those residing in areas with a high PCDMP participation (≥ 30.37%). According to the stratified analysis of HbA1c levels, people residing in areas with low PCDMP participation had significantly greater odds of having an HbA1c > 6.5%, which may indicate diabetes mellitus.
Conclusion: The lower the number of internal medicine clinics in an area participating in PCDMP was, the greater the possibility of an HbA1c > 6.5%. Our findings advocate the need for the government to pay attention to chronic disease management programs, which may lead individuals to have normal HbA1c levels (< 6.5%).
Changing Characteristics of Young Suicide Attempters in Tokyo, Japan
Authors: Narishige Ryuichiro , Otaka Yasushi , Tateno Amane
Published: April 2024

Background
The number of young suicides in Japan has shifted from a decreasing trend to a flat or increasing trend since 2017. In order to identify the factors behind these changes, we investigated changes in the characteristics of young suicide attempters.
Methods
The subjects were suicide attempters under 30 years old who were admitted to the Critical Care Medical Center of Nippon Medical School Hospital between January 1, 2010 and December 31, 2021. They were divided into two groups, one for pre-2017, and the other for post-2017. The means of suicide attempt, sociodemographic data, psychiatric diagnoses, and causes and motives of suicide attempts were retrospectively examined from medical records, and the two groups were compared and statistically analyzed.
Results
The proportion of suicide attempters under 30 years old was 27.9% (143 of 513) before 2017, compared to 38.0% (132 of 347) after 2017, with a significant increase in the latter group. There was a significant increase in the number of suicide attempters under 30 years old from 2017 to 2021 with respect to females and the percentage of drug overdoses, but no significant changes were observed in regard to employment status, residential status, history of self-harm, history of psychiatric consultation, psychiatric diagnosis, and causes and motives for suicide attempts.
Conclusions
As well as in young suicides, trend changes were observed between 2010–2016 and 2017–2021 with respect to suicide attempts by people under 30 years old, suggesting that the changes may be related to an increase in drug overdoses. It may be necessary to impose regulations on the ease with which information about drug overdoses can be obtained.
Rosa roxburghii Tratt Residue Can be Used as a Novel Feed Resource for Cattle
Authors: Song Xinyu , Yang Yi , Wang Chong , Zhu Wen , Wu Wenxuan
Published: April 2024

Rosa roxburghii tratt residue (RRTR) is a regional and uncommon byproduct in Guizhou. Little information is available on whether RRTR can be used as feed for ruminants. In this study, the feasibility of using RRTR as a new feed resource for cattle was investigated by chemical composition analysis, in vitrogas production(Trial 1) and animal feeding experiments (Trial 2). In trial 1, compared to the commonly used fruit residues, RRTR had a medium proximate nutrientlevel; the in vitro gas production at 24 h (166.67 mL) and dynamics fellwithin the normal range. In trial 2, 16 cattle were allocated to the control and treatment groups,with 8 replicates of 1 cattle each. Cattle in the control group were fed a basal diet without RRTR,while those in the treatment group were fed a diet containing 30% RRTR. Feeding RRTR had little effect on the growth performance of the control and treatment cattle (P>0.05). The feed-to-gain ratio was greaterin the treatment group than in the control group throughout the trial period (P<0.05). Compared with those in the control group, the plasma urea levels in the treatment group were lower (P<0.05), and the levels of other plasma biochemical metabolites were not differentbetween the two groups of cattle (P>0.05). The in vivo rumen fermentation parameters did not differ between thecontrol and treatment groups (P>0.05). Our findings indicate that RRTR has a nutritional profile similar to that ofcommonly used fruit residues; improves plasma protein utilization efficiency; and has little negative impact on growth performance, blood metabolites, and rumen fermentation parameters in cattle. Accordingly, RRTR can serve as a novel feed resource for cattle.
Logarithmic vanishing theorems on Weakly 1-complete Kahler manifolds
Authors: Lu Shilong
Published: April 2024

In this paper, we prove a logarithmic vanishing theorem on weakly $1$-complete k\"ahler manifold, which is a generalization of Huang-Liu-Wan-Yang's result on compact k\"ahler manifold. We first briefly introduce the local case of the theorem, which can be obtained as a corollary of the compact k\"ahler case. Next, we prove the global case of the theorem. The difficulty here is how to find a continuous solution $\psi$ from a sequence ${\psi_v}$ of discrete solutions of equation $\varphi_v=\bar\partial\psi_v$, such that for each $v\in \mathbb{R}$, $\varphi_v=\bar\partial\psi$. In this paper, the continuous solution is given by using the approximation theorem.
2020 Mathematics Subject Classification. 32Q15,14F17.
Use of antipsychotic drugs during radiotherapy in adult cancer patients in Korea: A nationwide retrospective cohort study based on the health insurance review and assessment service database
Authors: Hwang In Gyu , Park Song E , Kim Sun Mi , Kang Dae Ryong , Go Tae-Hwa , Hong Se Hwa , Ha Yong-Chan , Park Shin Young , Lee Hyunho , Choi Jin Hwa
Published: April 2024

Background
Antipsychotic drugs (APDs) are used for treating mental illnesses and are also used by cancer patients. This study aimed to evaluate APD use in adult cancer patients who received radiotherapy (RT) in South Korea and assess the effects of APD use during RT on survival.
Methods
This retrospective cohort study utilized the Health Insurance Review and Assessment Service database of Korea. We included adult cancer patients who underwent RT or chemotherapy (CTx, cisplatin, or 5-Fluorouracil) between 2010 and 2020. The APDs included in the analysis were aripiprazole, quetiapine, olanzapine, risperidone, haloperidol, and chlorpromazine.
Results
Overall, 725,897 patients received RT, and 115,500 received concomitant chemo-radiotherapy (CCRT). Of them, 41,118 (5.6%) took APDs during RT, and 8,129 (7%) took APDs during CCRT. Overall, 27,789 (67.58%) patients who took APDs during RT were men, and 28,004 (68.2%) were aged ≥ 60 years. The most frequently used APD during RT was quetiapine (64.93%). The three cancer sites with the highest frequency of APD users during RT were the lungs (21.64%), breast (5.09%), and colorectum (4.44%). The three cancer sites with a high proportion of APD use during RT were the lungs (14.87%), brain (14.27%), and esophagus (12.95%). Patients who took APDs during RT had a higher mortality rate (HR: 3.45, p < 0.0001) compared to the non-APD patients. The patients taking high-dose APD had a lower mortality rate than those on low-dose APD (HR: 3.23 vs. 3.46, p < 0.0001).
Conclusions
Only 5.6% of patients who underwent RT used APDs, and quetiapine was the most frequently prescribed APD during RT. Patients who used APDs during RT had poorer survival than those who did not. Further studies are required to elucidate the effects of APDs on cancer patients.
Trial registration:
This study is retrospectively registered
Dehydration of Turbine Engine Lubricant Oil Using Cellulose Hydrogel
Authors: Estevam Bianca Ramos , Perez Isadora Dias , Tsuruta Karina Mayumi , Neto Roberto Mendes Finzi , Mancuzo Mechelangelo Viana , Cavallini Aldemir Aparecido , Moraes Ângela Maria , Fregolente Leonardo Vasconcelos
Published: April 2024

Contamination of oils by water is a recurring problem in the industry and can damage engines and equipment. Oil dehydration systems with hydrogels have shown promise for the removal of free, soluble, and emulsified water. This work evaluates, in an unprecedented way, the dehydration of turbine lubricating oil using a cellulose hydrogel. The hydrophilic polymer was characterized through high-resolution SEM, EDS, FTIR, BET, TGA, DVS and swelling degree. The oil was evaluated regarding its composition and physicochemical properties. The performance of the hydrogel in the treatment of water-in-oil emulsion was analyzed in batch and continuous flow systems. A fixed bed apparatus was specially designed and sized according to the industry's specifications to simulate on-site application. The batch treatment was evaluated using orbital and full tumbling inversion mixing systems, both reaching removal efficiency of around 47%. Mixing by full tumbling allowed greater stability of the emulsion and control of the water concentration, but it required a longer time to enable adequate water uptake by the hydrogel. The efficiency of the hydrogel in the continuous flow system was affected by retention time and inlet water concentration. With a retention time of 12 min, it was possible to treat 1 L of oil, reducing the water concentration from 412 ppm to 197 ppm and the turbidity from Haze 6 to Haze 1. Thus, the cellulose hydrogel was efficient in dehydrating turbine lubricating oil, opening up the possibility of expanding its use to industrial facilities.
Prevalence and clinical correlates of anxiety symptoms in first-episode and drug-naïve major depressive disorder patients with dyslipidemia at different ages of onset: a large cross-sectional study
Authors: Wang Guanjun , Liu Yanting , Ji Yunxin , Wang Kuilai , Lang xiaoe , Zhang Xiang
Published: April 2024

Background
Major depressive disorder (MDD) patients often have different clinical manifestations at different age of onset. Anxiety symptoms are frequently seen in patients with MDD, and dyslipidemia is also prevalent in these populations. There is limited reporting on the frequency of anxiety symptoms and their associations with clinical factors in patients with abnormal lipid metabolism who have MDD.
Methods
Our study included 1718 first-episode untreated MDD outpatients aged 18–60 years, 1408 of whom had dyslipidemia. We collected basic information, clinically relevant data, and biochemical indicators from these patients. Anxiety, depression and psychiatric symptoms were evaluated by Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) and Positive and Negative Syndrome Scale (PANSS) positive subscale, respectively.
Results
Anxiety symptoms were found in 57.8% of depressed outpatients with dyslipidemia, a rate significantly higher than in MDD patients with normal lipid levels. No statistical difference was observed in the prevalence of anxiety symptoms between the early adulthood onset (EAO) group and mid-adulthood onset (MAO) group. Anxiety symptoms were significantly correlated with both HAMD and PANSS scores, regardless of the age of onset. Thyroid-stimulating hormone (TSH), total cholesterol (TC) levels and suicide attempts were independently associated with anxiety symptoms in the EAO group, whereas fasting blood glucose (FBG) was independently related to anxiety symptoms in the MAO group.
Conclusions
Our research findings indicated that the age of MDD onset in patients with dyslipidemia did not impact the presence of anxiety symptom. The clinical factors linked to anxiety symptoms varied between the EAO and MAO groups, potentially aiding in the prediction of anxiety symptoms in the specific population.