bluuebunny/crossref_metadata_2025 huggingface dataset:
Intravesical Ty21a treatment of non-muscle invasive bladder cancer induces immune responses that correlate with safety and may be associated to therapy potential
Authors: Derré Laurent , Lucca Ilaria , Cesson Valérie , Bohner Perrine , Crettenand Francois , Rodrigues-Dias Sonia-Cristina , Dartiguenave Florence , Masnada Audrey , Teixeira-Pereira Carla , Benmerzoug Sulayman , Chevalier Mathieu F , Domingos-Pereira Sonia , Nguyen Sylvain , Polak Lenka , Schneider Anna K , Jichlinski Patrice , Roth Beat , Nardelli-Haefliger Denise
Published: December 2023

Background

Standard of care treatment of non-muscle invasive bladder cancer (NMIBC) with intravesical Bacillus Calmette Guérin (BCG) is associated with side effects, disease recurrence/progression and supply shortages. We recently showed in a phase I trial (NCT03421236) that intravesical instillation in patients with NMIBC with the maximal tolerated dose of Ty21a/Vivotif, the oral vaccine against typhoid fever, might have a better safety profile. In the present report, we assessed the immunogenicity of intravesical Ty21a in patients of the clinical trial that had received the maximal tolerated dose and compared it with data obtained in patients that had received standard BCG.

Methods

Urinary cytokines and immune cells of patients with NMIBC treated with intravesical instillations of Ty21a (n=13, groups A and F inNCT03421236) or with standard BCG in a concomitant observational study (n=12, UROV1) were determined by Luminex and flow cytometry, respectively. Serum anti-lipopolysaccharide Typhi antibodies and circulating Ty21a-specific T-cell responses were also determined in the Ty21a patients. Multiple comparisons of different paired variables were performed with a mixed-effect analysis, followed by Sidak post-test. Single comparisons were performed with a paired or an unpaired Student’s t-test.

Results

As compared with BCG, Ty21a induced lower levels of inflammatory urinary cytokines, which correlated to the milder adverse events (AEs) observed in Ty21a patients. However, both Ty21a and BCG induced a Th1 tumor environment. Peripheral Ty21a-specific T-cell responses and/or antibodies were observed in most Ty21a patients, pointing the bladder as an efficient local immune inductive site. Besides, Ty21a-mediated stimulation of unconventional Vδ2 T cells was also observed, which turned out more efficient than BCG. Finally, few Ty21a instillations were sufficient for increasing urinary infiltration of dendritic cells and T cells, which were previously associated with therapeutic efficacy in the orthotopic mouse model of NMIBC.

Conclusions

Ty21a immunotherapy of patient with NMIBC is promising with fewer inflammatory cytokines and mild AE, but induction of immune responses with possible antitumor potentials. Future phase II clinical trials are necessary to explore possible efficacy of intravesical Ty21a.
Daratumumab for autoimmune diseases: a systematic review
Authors: Holzer Marie-Therese , Ruffer Nikolas , Huber Tobias B. , Kötter Ina , Ostendorf Lennard , Krusche Martin
Published: December 2023

Objective

Refractory autoimmune diseases remain a significant challenge in clinical practice and new therapeutic options are needed. This systematic review evaluates the existing reported data on the CD38-targeting antibody daratumumab as a new therapeutic approach in autoantibody-mediated autoimmune diseases.

Methods

A protocolised systematic literature review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was performed. Two databases (Medline and Embase) were searched for suitable studies. Usage of daratumumab in non-oncological or non-transplantation associated diseases with autoimmune pathophysiology was analysed including patient characteristics, therapeutic regimen, adverse events and patient outcome.

Results

38 publications reporting the clinical course of 83 patients met the inclusion criteria. Daratumumab usage was reported in therapy-refractory cases (median of 5 different previous therapies) in 24 different autoimmune diseases. The median number of applications of daratumumab was 4, mainly via intravenous applications (87%). Concomitant treatment included glucocorticoids in 64% of patients, intravenous immunoglobulins (33%) and rituximab (17%). Remission or improvement of disease was reported in 81% of patients. Autoantibody depletion or reduction was stated in 52% of patients. Death occurred in three patients (3%). Adverse events were reported in 45% of patients including application-associated reaction (20%), infection (19%) and hypogammaglobulinaemia (33%).

Conclusion

Targeting CD38 via daratumumab is a new promising therapeutic option in therapy refractory autoimmune diseases. Efficacy as well as optimal therapeutic regimen and management or prevention of adverse events require further investigation. Therefore, systematic clinical trials of this therapeutic approach are needed.
Investigation of motor unit behavior in exercise and sports physiology: challenges and perspectives
Authors: Möck Sebastian , Del Vecchio Alessandro
Published: December 2023

Several methods are in use to record and analyze neuronal activation, each with specific advantages and challenges. New developments like the decomposition of high-density surface electromyography (HDsEMG) have enabled novel insights into discharge characteristics noninvasively in laboratory settings but face certain challenges to be applied in sports physiology in a broader scope. Several challenges can be accounted for by methodological considerations, others require further technological developments to allow this technology to be used in more applied settings. This paper aims to describe the developments of surface electromyography and identify the challenges and perspectives of HDsEMG in the context of an application in sports physiology. We further discuss methodological possibilities to overcome some of the challenges to investigate specific research questions and identify areas that require further advancements.
Stratigraphic mapping of paintings by multispectral reflectography
Authors: Dal Fovo Alice , Fontana Raffaella
Published: December 2023

Despite recent technological advances, it is currently not possible to uniquely and noninvasively measure the micrometric thickness of pictorial layers in paintings. The presence of optically opaque materials (pigments) severely limits the detection capability, as it hinders the penetration of the probe's near-infrared radiation, typically employed for this purpose. In our previous work, we explored the possibility of using diffuse reflectance spectroscopy (DRS) to achieve stratigraphic information about painting materials. We showed that the thickness of pictorial layers can be quantified by the intensity of the spectral reflectance factor measured at a given wavelength in the infrared, i.e., an easily detectable spectral feature. In the present work, we extend the previously proposed method by applying multispectral reflectography to measure new ad hoc prepared pictorial samples and a mock-up simulating a Mondrian painting. We thus demonstrate that it is possible to obtain 2D and 3D stratigraphic maps of the pictorial layer over large areas with the same measurement time and spatial resolution as multispectral scanning reflectography.
Blockchain-based Execution of BPMN Choreographies with Multiple Instances
Authors: Corradini Flavio , Marcelletti Alessandro , Morichetta Andrea , Polini Andrea , Re Barbara , Tiezzi Francesco
Published: December 2023

The recent growth of blockchain has opened the use of technology for supporting the creation of new kinds of trustable systems. Model-driven engineering methodologies have been conceived to facilitate the automatic generation and deployment of software applications starting from the definition and refinement of abstract specification. BPMN choreography diagrams permit the representation of inter-organisational systems from a high-level perspective, just focusing on message exchange. However, the usage of such models in a blockchain-based setting has been limited to scenarios in which parties are involved in single interactions. This aspect becomes significantly relevant when considering complex applications, and in particular those in the realm of the Internet of Things. In these cases, the multiplicity of parties and their actions is crucial and requires novel solutions. In this work, we propose a novel approach for modelling, refining, deploying, and executing a Choreography on the blockchain, taking into account those scenarios in which the model includes multiple-instances. In particular, the considered models are translated into smart contracts able to correctly manage multiplicity. To demonstrate the approach’s feasibility, we designed and presented a Smart Thermostat application, that is executed on the Polygon blockchain.
2023 H. H. Uhlig Fellowship Research Fellowship – Summary Report: Zinc Plating on Ti3C2T
x
MXene Characterized through in-situ Optical Microscopy and UV-Vis Spectroscopy
Authors: Matthews Kyle
Published: December 2023

Zinc metal batteries are promising candidates for multiple energy storage applications. Zinc dendrite formation is one of the major factors inhibiting their implementation, and multiple directions have been explored to mitigate this. MXenes are 2D transition metal carbides with the structure Mn+1XnTx. MXenes have high conductivity with hydrophilic, redox-active terminations, which makes them prime candidates in energy storage applications. MXenes (mainly Ti3C2Tx) have established use in Zn battery dendrite suppression as a coating on the Zn metal or an electrolyte additive. There is considerably less work on using MXenes as an anode-free electrode, which would maximize energy density and zinc utilization, warranting exploration.
Sex as a biological variable for cardiovascular physiology
Authors: Lindsey Merry L. , Usselman Charlotte W. , Ripplinger Crystal M. , Carter Jason R. , DeLeon-Pennell Kristine Y.
Published: December 2023

There have been ongoing efforts by federal agencies and scientific communities since the early 1990s to incorporate sex and/or gender in all aspects of cardiovascular research. Scientific journals provide a critical function as change agents to influence transformation by encouraging submissions for topic areas, and by setting standards and expectations for articles submitted to the journal. As part of ongoing efforts to advance sex and gender in cardiovascular physiology research, the American Journal of Physiology-Heart and Circulatory Physiology recently launched a call for papers on Considering Sex as a Biological Variable. This call was an overwhelming success, resulting in 78 articles published in this collection. This review summarizes the major themes of the collection, including Sex as a Biological Variable Within: Endothelial Cell and Vascular Physiology, Cardiovascular Immunity and Inflammation, Metabolism and Mitochondrial Energy, Extracellular Matrix Turnover and Fibrosis, Neurohormonal Signaling, and Cardiovascular Clinical and Epidemiology Assessments. Several articles also focused on establishing rigor and reproducibility of key physiological measurements involved in cardiovascular health and disease, as well as recommendations and considerations for study design. Combined, these articles summarize our current understanding of sex and gender influences on cardiovascular physiology and pathophysiology and provide insight into future directions needed to further expand our knowledge.
Real-Time Integration of Identification and Semiactive Optimization Control for Mass Damper-Building Combined Systems under Known/Unknown Seismic Excitations
Authors: Yin Chang , Lu Jubin , Xiang Chunyan , Lei Ying
Published: December 2023

The integration of structural identification and vibration optimal control has been studied. Since the semiactive optimization vibrational control of civil structures needs to be implemented by massive control devices such as mass dampers, it is necessary to investigate the real-time integration of identification and semiactive optimization vibration control for mass damper-building combined systems. However, there is a lack of such studies in the literature. In this paper, a methodology is presented for real-time integration of identification and semiactive optimization vibration control of the mass damper-building combined system under known/unknown seismic excitations. For the combined system under known seismic excitations, the identification is implemented by the extended Kalman filter (EKF) using only partial structural acceleration responses. The identified structural state and parameters of mass damper-building systems are integrated in real time for the optimal control of systems by the linear-quadratic regulator (LQR) control algorithm and the Hrovat semiactive optimization control strategy via semiactive optimization mass dampers (SAMD). Then, it is extended to the scenario of unknown seismic excitations. The partially measured structural acceleration responses are absolute ones in this case, so the generalized extended Kalman filter with unknown input (GEKF-UI) developed by the authors is used to identify the structural input-state parameters of the mass dampers-building combined systems. The identification results are also integrated in real time for the semiactive optimization control of the combined system via SAMD. Two numerical simulation examples are used to test the proposed integration methods. It is shown that the proposed integration methods can reach almost the same optimal control effects as the conventional semiactive optimization control with known parameters of the mass damper-building combined systems under known/unknown seismic excitations.
Branchial Motion Assessment in Abalone Using Photoplethysmography
Authors: Bautista López R. Z. , Yáñez Mendiola J. , Sicard González M. T.
Published: December 2023

The abalone, a gastropod mollusk belonging to the Haliotidae family, has been a subject of research with a focus on its behavior in response to various environmental factors, including temperature fluctuations and hypoxia. While existing studies have primarily explored abalone behavior in relation to environmental changes, there remains a significant amount to be discovered regarding their behavioral patterns. There are studies in which recordings of readings have been made (indirect methods) of the heart rate of the abalone since it is believed that it is one of the parameters affected due to the changes in temperature and dissolved oxygen in its environment. The main disadvantage of some procedures to measure heart rate in abalone is that an incision is made near the heart, through this incision the measurement is made using the photoplethysmography technique. Another parameter that is affected by these changes (temperature and hypoxia) is respiratory rate. Temperature is an important factor that can reduce oxygen solubility and thus alter abalone respiration; so in this work, we propose to use the technique of photoplethysmography: a method involving the measurement of changes in volume within a biological organ, which offers a unique opportunity to monitor these changes. We adapt this technique to measure gill movements in abalone, a critical indicator of respiratory activity in these marine mollusks. By utilizing a pulse oximetry setup and synchronous detection, we establish an innovative approach to gill movement analysis. This approach employs a pulse train and synchronous demodulation technique, the train of pulses is guided through an optical fiber to one of the respiratory orifices of the abalone to effectively detect and analyze the gill movements of abalone. Additionally, the role of frequency of its gill movements is highlighted as another critical variable of interest within the broader study of Haliotis fulgens, shedding light on the multifaceted nature of abalone behavior and responses to their surroundings. This research contributes to a deeper understanding of abalone physiology and behavior, offering insights into their adaptation to changing environmental conditions.
Supplementary Figure 4 from RETRACTED: Physical and Functional Interaction of DNA Methyltransferase 3A with Mbd3 and Brg1 in Mouse Lymphosarcoma Cells
Authors: Datta Jhrana , Majumder Sarmila , Bai Shoumei , Ghoshal Kalpana , Kutay Huban , Smith David Spencer , Crabb John W. , Jacob Samson T.
Published: December 2023

Supplementary Figure 4 from RETRACTED: Physical and Functional Interaction of DNA Methyltransferase 3A with Mbd3 and Brg1 in Mouse Lymphosarcoma Cells
Supplementary Figure 2 from RETRACTED: Physical and Functional Interaction of DNA Methyltransferase 3A with Mbd3 and Brg1 in Mouse Lymphosarcoma Cells
Authors: Datta Jhrana , Majumder Sarmila , Bai Shoumei , Ghoshal Kalpana , Kutay Huban , Smith David Spencer , Crabb John W. , Jacob Samson T.
Published: December 2023

Supplementary Figure 2 from RETRACTED: Physical and Functional Interaction of DNA Methyltransferase 3A with Mbd3 and Brg1 in Mouse Lymphosarcoma Cells
Supplementary Figures 1-6 from FGFR3 Alterations in Bladder Cancer Stimulate Serine Synthesis to Induce Immune-Inert Macrophages That Suppress T-cell Recruitment and Activation
Authors: Ouyang Yi , Ou Ziwei , Zhong Wenlong , Yang Jin , Fu Sha , Ouyang Nengtai , Chen Junyu , Xu Longhao , Wu Daqin , Qian Junan , Lin Yi , Lin Tianxin , Huang Jian
Published: December 2023

Supplementary Figures 1-6
Figure S6 from Fructose-Induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy
Authors: Cui Yanfen , Tian Jianfei , Wang Zhaosong , Guo Hui , Zhang He , Wang Zhiyong , Liu Hui , Song Weijie , Liu Liming , Tian Ruinan , Zuo Xiaoyan , Ren Sixin , Niu Ruifang , Zhang Fei
Published: December 2023

Figure S6
Supplementary Figures 1-7 from Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy
Authors: Mukhopadhyay Suman , Huang Hsin-Yi , Lin Ziyan , Ranieri Michela , Li Shuai , Sahu Soumyadip , Liu Yingzhuo , Ban Yi , Guidry Kayla , Hu Hai , Lopez Alfonso , Sherman Fiona , Tan Yi Jer , Lee Yeuan Ting , Armstrong Amanda P. , Dolgalev Igor , Sahu Priyanka , Zhang Tinghu , Lu Wenchao , Gray Nathanael S. , Christensen James G. , Tang Tracy T. , Velcheti Vamsidhar , Khodadadi-Jamayran Alireza , Wong Kwok-Kin , Neel Benjamin G.
Published: December 2023

Supplementary Figures 1-7 including Figure legends
All Roads Lead to Rome: YAP/TAZ Activity Influences Efficacy of KRASG12C Inhibitors
Authors: Johnson Christian W. , Haigis Kevin M.
Published: December 2023

The development of direct inhibitors of KRASG12C represents a monumental step forward in the field of oncology. Nevertheless, there is considerable opportunity to enhance response rates to KRASG12C inhibitors. In this issue of Cancer Research, three investigative teams explore the modulation of KRASG12C inhibitor activity in lung, colorectal, and pancreatic cancers using CRISPR-based knockout screens. While each group identified and validated a variety of genes and pathways conferring resistance to KRASG12C inhibition, all three groups converged upon activation of YAP/TAZ as a common means of resistance. While coinhibition of KRASG12C and YAP/TAZ did not cause complete tumor regression in xenograft models, combining YAP/TAZ inhibition was capable of significantly extending the response of tumors to KRASG12C inhibition.

See related articles by Mukhopadhyay et al., p. 4095, Edwards et al., p. 4112, and Prahallad et al., p. 4130
Supplementary Figure S1 from The Clinical Implications of Reversions in Patients with Advanced Pancreatic Cancer and Pathogenic Variants in BRCA1, BRCA2, or PALB2 after Progression on Rucaparib
Authors: Brown Timothy J. , Yablonovitch Arielle , Till Jacob E. , Yen Jennifer , Kiedrowski Lesli A. , Hood Ryan , O'Hara Mark H. , Teitelbaum Ursina , Karasic Thomas B. , Schneider Charles , Carpenter Erica L. , Nathanson Katherine , Domchek Susan M. , Reiss Kim A.
Published: December 2023

VAF association with 12 month OS
Supplementary Table 5 from Cancer-Associated Fibroblast-Like Tumor Cells Remodel the Ewing Sarcoma Tumor Microenvironment
Authors: Wrenn Emma D. , Apfelbaum April A. , Rudzinski Erin R. , Deng Xuemei , Jiang Wei , Sud Sudha , Van Noord Raelene A. , Newman Erika A. , Garcia Nicolas M. , Miyaki Aya , Hoglund Virginia J. , Bhise Shruti S. , Kanaan Sami B. , Waltner Olivia G. , Furlan Scott N. , Lawlor Elizabeth R.
Published: December 2023

Supplemental Table 5. Q3 normalized gene expression counts for CHLA10 xenograft digital spatial profiling.
Supplementary Table S5 from Genomic Tumor Correlates of Clinical Outcomes Following Organ-Sparing Chemoradiation Therapy for Bladder Cancer
Authors: Kamran Sophia C. , Zhou Yuzhen , Otani Keisuke , Drumm Michael , Otani Yukako , Wu Shulin , Wu Chin-Lee , Feldman Adam S. , Wszolek Matthew , Lee Richard J. , Saylor Philip J. , Lennerz Jochen , Van Allen Eliezer , Willers Henning , Hong Theodore S. , Liu Yang , Davicioni Elai , Gibb Ewan A. , Shipley William U. , Mouw Kent W. , Efstathiou Jason A. , Miyamoto David T.
Published: December 2023

List of ERCC2 mutations within cohort
Supplementary Figure S5 from Genomic Tumor Correlates of Clinical Outcomes Following Organ-Sparing Chemoradiation Therapy for Bladder Cancer
Authors: Kamran Sophia C. , Zhou Yuzhen , Otani Keisuke , Drumm Michael , Otani Yukako , Wu Shulin , Wu Chin-Lee , Feldman Adam S. , Wszolek Matthew , Lee Richard J. , Saylor Philip J. , Lennerz Jochen , Van Allen Eliezer , Willers Henning , Hong Theodore S. , Liu Yang , Davicioni Elai , Gibb Ewan A. , Shipley William U. , Mouw Kent W. , Efstathiou Jason A. , Miyamoto David T.
Published: December 2023

FGFR3 mutation correlation with FGFR3 gene expression scores.
Supplementary Table S6 from Safety and Efficacy of NY-ESO-1 Antigen-Specific T-Cell Receptor Gene-Transduced T Lymphocytes in Patients with Synovial Sarcoma: A Phase I/II Clinical Trial
Authors: Kawai Akira , Ishihara Mikiya , Nakamura Tomoki , Kitano Shigehisa , Iwata Shintaro , Takada Kohichi , Emori Makoto , Kato Koji , Endo Makoto , Matsumoto Yoshihiro , Kakunaga Shigeki , Sato Eiichi , Miyahara Yoshihiro , Morino Kunihiko , Tanaka Shinya , Takahashi Shuichi , Matsuo Fujio , Matsumine Akihiko , Kageyama Shinichi , Ueda Takafumi
Published: December 2023

Summary of adverse events and adverse drug reactions
Supplementary Table S13 from SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials
Authors: Conte Benedetta , Boni Luca , Bisagni Giancarlo , Durando Antonio , Sanna Giovanni , Gori Stefania , Garrone Ornella , Tamberi Stefano , De Placido Sabino , Schettini Francesco , Pazzola Antonio , Ponzone Riccardo , Montemurro Filippo , Lunardi Gianluigi , Notaro Rosario , De Angioletti Maria , Turletti Anna , Mansutti Mauro , Puglisi Fabio , Frassoldati Antonio , Porpiglia Mauro , Fabi Alessandra , Generali Daniele , Scognamiglio Giovanni , Rossi Maura , Brasó-Maristany Fara , Prat Aleix , Cardinali Barbara , Piccioli Patrizia , Serra Martina , Lastraioli Sonia , Bighin Claudia , Poggio Francesca , Lambertini Matteo , Del Mastro Lucia
Published: December 2023

Multivariable Fine-Gray model for skeletal events
Supplementary Figure S8 from Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma
Authors: Marino-Enriquez Adrian , Novotny Jan Philipp , Gulhan Doga C. , Klooster Isabella , Tran Antuan V. , Kasbo Macy , Lundberg Meijun Z. , Ou Wen-Bin , Tao Derrick L. , Pilco-Janeta Daniel F. , Mao Victor Y. , Zenke Frank T. , Leeper Brittaney A. , Gokhale Prafulla C. , Cowley Glenn S. , Baker Laurence H. , Ballman Karla V. , Root David E. , Albers Joachim , Park Peter J. , George Suzanne , Fletcher Jonathan A.
Published: December 2023

Supplementary Figure S8:
Synergistic effects of peposertib and low-dose doxorubicin combinations in LMS cells. Cell proliferation
assay (BrdU incorporation) demonstrates that addition of low-dose doxorubicin to DNA-PKi treatment
results in synergistic effects on LMS03, LMS04 and LMS05 cell proliferation. Cells were treated for 7
days with the drug combinations at the indicated doses; BrdU incorporation over 24h was measured at
day 7 with a luminescence-based ELISA assay (Roche). Synergy scores and heatmap / surface plots
were generated using SynergyFinder (RRID:SCR_019318)(35).
Supplementary Data S1 from SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials
Authors: Conte Benedetta , Boni Luca , Bisagni Giancarlo , Durando Antonio , Sanna Giovanni , Gori Stefania , Garrone Ornella , Tamberi Stefano , De Placido Sabino , Schettini Francesco , Pazzola Antonio , Ponzone Riccardo , Montemurro Filippo , Lunardi Gianluigi , Notaro Rosario , De Angioletti Maria , Turletti Anna , Mansutti Mauro , Puglisi Fabio , Frassoldati Antonio , Porpiglia Mauro , Fabi Alessandra , Generali Daniele , Scognamiglio Giovanni , Rossi Maura , Brasó-Maristany Fara , Prat Aleix , Cardinali Barbara , Piccioli Patrizia , Serra Martina , Lastraioli Sonia , Bighin Claudia , Poggio Francesca , Lambertini Matteo , Del Mastro Lucia
Published: December 2023

Template to request patient-level data to corresponding author
Table S3 from Lenvatinib, Toripalimab plus FOLFOX Chemotherapy in Hepatocellular Carcinoma Patients with Extrahepatic Metastasis: A Biomolecular Exploratory, Phase II Trial (LTSC)
Authors: He MinKe , Huang YeXing , Du ZeFeng , Lai ZhiCheng , Ouyang Hanyue , Shen JingXian , Wen DongSheng , Li QiJiong , Zhang YaoJun , Wei Wei , Chen MinShan , Xu Li , Kan Anna , Shi Ming
Published: December 2023

Tumor Response
Supplementary Figure S1 from CD24hiCD27+ Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer
Authors: Huang Huanhuan , Yao Yao , Shen Lesang , Jiang Jingxin , Zhang Ting , Xiong Jia , Li Jiaxin , Sun Shanshan , Zheng Siwei , Jia Fang , Zhou Jun , Yu Xiuyan , Chen Wuzhen , Shen Jun , Xia Wenjie , Shao Xuan , Wang Qingqing , Huang Jian , Ni Chao
Published: December 2023

Fig. S1. The features of B cells in the mLNs of BC.
Data from OvaPrint—A Cell-free DNA Methylation Liquid Biopsy for the Risk Assessment of High-grade Serous Ovarian Cancer
Authors: Buckley David N. , Lewinger Juan Pablo , Gooden Gerald , Spillman Monique , Neuman Monica , Guo X. Mona , Tew Ben Yi , Miller Heather , Khetan Varun U. , Shulman Lee P. , Roman Lynda , Salhia Bodour
Published: December 2023

AbstractPurpose:
High-grade serous ovarian carcinoma (HGSOC) is the most lethal epithelial ovarian cancer (EOC) and is often diagnosed at late stage. In women with a known pelvic mass, surgery followed by pathologic assessment is the most reliable way to diagnose EOC and there are still no effective screening tools in asymptomatic women. In the current study, we developed a cell-free DNA (cfDNA) methylation liquid biopsy for the risk assessment of early-stage HGSOC.
Experimental Design:
We performed reduced representation bisulfite sequencing to identify differentially methylated regions (DMR) between HGSOC and normal ovarian and fallopian tube tissue. Next, we performed hybridization probe capture for 1,677 DMRs and constructed a classifier (OvaPrint) on an independent set of cfDNA samples to discriminate HGSOC from benign masses. We also analyzed a series of non-HGSOC EOC, including low-grade and borderline samples to assess the generalizability of OvaPrint. A total of 372 samples (tissue n = 59, plasma n = 313) were analyzed in this study.
Results:
OvaPrint achieved a positive predictive value of 95% and a negative predictive value of 88% for discriminating HGSOC from benign masses, surpassing other commercial tests. OvaPrint was less sensitive for non-HGSOC EOC, albeit it may have potential utility for identifying low-grade and borderline tumors with higher malignant potential.
Conclusions:
OvaPrint is a highly sensitive and specific test that can be used for the risk assessment of HGSOC in symptomatic women. Prospective studies are warranted to validate OvaPrint for HGSOC and further develop it for non-HGSOC EOC histotypes in both symptomatic and asymptomatic women with adnexal masses.
HQ, tradução e personagem: reflexões a partir de Batman: The Killing Joke
Authors: Micheletti Luiz Ricardo Gonsalez
Published: December 2023

Pretende mostrar como a tradução ou falta da mesma altera ou preserva a caracterização das personagens na graphic novel, cujo título é Batman: the killing joke. O corpus está formado pela obra original e três versões de tradução para o português brasileiro. Para a análise, foram utilizadas as modalidades de tradução, de Aubert (1998), tendo como recorte a modalidade ‘omissão’ e foi focalizado como a falta de tradução ou modificações em determinados trechos levam à descaracterização das personagens, mais especificamente Barbara Gordon e Coringa, ao se comparar duas traduções da Editora Abril e uma tradução da Editora Panini com a versão original. Consideram-se os contextos de produção, publicação e recepção das obras no mercado brasileiro. Assim, a omissão ou alteração de segmentos do texto original descaracteriza as personagens ao excluir total ou parcialmente traços de personalidade que poderiam auxiliar o leitor a entender melhor suas complexidades, além de haver a perda do ‘entrelaçamento’ (Groensteen, 2015) no decorrer de alguns trechos das traduções.
Os (des)limites do layout regular: o espaço vazio na quadriculação de Hedra
Authors: Borges Caetano Galindo
Published: December 2023

Trata do uso dos espaços vazios na página de quadrinhos a partir da sua materialidade. No entanto, não trata de sarjetas. A proposta é entender como esses espaços podem ser usados de forma a influir nas dinâmicas visuais e narrativas da página. Dar-se-á aqui um recorte a partir do conceito de layout regular (Groensteen, 2015, p.103) e como esses espaços deixados em branco podem influenciar o mesmo. Para tanto, conjugando teoria visual e artrologia será feito um estudo de caso usando a obra Hedra, de Jesse Lonergan. O objetivo é mostrar como a omissão de quadros criando espaços vazios permite manipular a composição da página sem romper totalmente com a estrutura fixa que o layout regular propõe. Isso, entendendo que existe uma dinâmica de expectativas cumpridas e subvertidas onde o espaço vazio torna-se elemento retórico e poético.
Persistent right aortic arch in the cat: a case report from a late surgical approach
Authors: Duzanski Anderson Prado , Lorigados Carla Aparecida Batista , Santos Igor de Almeida , Unruh Silvana Maria , Matera Julia Maria , Ambrósio Aline Magalhães , Macedo Jeovan Santos , Coelho Bruna Maria Pereira , Hayashi Ayne Murata
Published: December 2023

Aortic arch anomalies can give rise to vascular rings, such as persistent right aortic arch (PRAA), a rare vascular anomaly in cats with significant health implications. Here, we report late surgical correction in a case of PRAA, an almost 12-month-old cat with the clinical syndrome of dysphagia and postprandial regurgitation. The patient was presented to the veterinary hospital at FMVZ-USP with a history of chronic regurgitation since puppyhood after weaning, with a significant worsening of the clinical condition 10 days ago. Computed tomography had a potential role in diagnosing and detecting complications of PRAA, allowing surgical planning. Approach via left thoracotomy and section of the arteriosus ligament resulted in the successful resolution of extrinsic esophageal compression due to PRAA with the restoration of normal swallowing of a dry diet by the cat and absence of esophageal sequelae on radiographic assessment in a six-month clinical follow-up.
Seroprevalence anti-Leptospira spp. antibodies and the risk factors in cattle of the tropical savannah of eastern Colombia
Authors: Guzman Barragan Blanca Lisseth , Molina Puentes María Margarita , Jaimes Camargo Karen Daniela , Tobón Torreglosa Julio César , Barragan Yessica Lorena Guzmán , Ballesteros González Catalina
Published: December 2023

Leptospirosis is a zoonotic disease in the tropical zone with a broad and endemic distribution. The condition is complex, where different host factors, serovar type, reservoirs, environment, and agricultural practices intervene. In cattle, the disease causes significant damage to the livestock sector, and the surrounding conditions can influence its dynamics. This study aimed to determine the seroprevalence of anti-Leptospira spp. antibodies and the risk factors in cattle in the tropical savannah from eastern Colombia. Blood was taken from the coccygeal veins of 1,000 animals. The MAT (Microagglutination) technique was used for the identification of the serogroup Autumnalis, Bataviae, Bratislava, Canicola, Copenhagen, Cynopteri, Grippotyphosa, Sejroe, Mini, Pomona, Shermani, Tarassovi, and Celledoni. Studies of risk factors were carried out according to the serovar through the calculation of X2 and OR. Seroprevalence of Leptospira spp. was 34.2% with 92.3% of herds. Pomona had the highest frequency of 7.9%, followed by Hardjo prajit with 7.0% and Grippotyphosa with 6.2%. Antibody agglutination with more than one serovar was seen in 102 (29.8%) samples. The serogroup with the highest correlations were Pomona and Hardjo prajit.
Q&A Label Learning
Authors: Kawamoto Kota , Uchida Masato
Published: December 2023

Assigning labels to instances is crucial for supervised machine learning. In this letter, we propose a novel annotation method, Q&A labeling, which involves a question generator that asks questions about the labels of the instances to be assigned and an annotator that answers the questions and assigns the corresponding labels to the instances. We derived a generative model of labels assigned according to two Q&A labeling procedures that differ in the way questions are asked and answered. We showed that in both procedures, the derived model is partially consistent with that assumed in previous studies. The main distinction of this study from previous ones lies in the fact that the label generative model was not assumed but, rather, derived based on the definition of a specific annotation method, Q&A labeling. We also derived a loss function to evaluate the classification risk of ordinary supervised machine learning using instances assigned Q&A labels and evaluated the upper bound of the classification error. The results indicate statistical consistency in learning with Q&A labels.
On the Effect of Anticipation on Reading Times
Authors: Pimentel Tiago , Meister Clara , Wilcox Ethan G. , Levy Roger P. , Cotterell Ryan
Published: December 2023

Over the past two decades, numerous studies have demonstrated how less-predictable (i.e., higher surprisal) words take more time to read. In general, these studies have implicitly assumed the reading process is purely responsive: Readers observe a new word and allocate time to process it as required. We argue that prior results are also compatible with a reading process that is at least partially anticipatory: Readers could make predictions about a future word and allocate time to process it based on their expectation. In this work, we operationalize this anticipation as a word’s contextual entropy. We assess the effect of anticipation on reading by comparing how well surprisal and contextual entropy predict reading times on four naturalistic reading datasets: two self-paced and two eye-tracking. Experimentally, across datasets and analyses, we find substantial evidence for effects of contextual entropy over surprisal on a word’s reading time (RT): In fact, entropy is sometimes better than surprisal in predicting a word’s RT. Spillover effects, however, are generally not captured by entropy, but only by surprisal. Further, we hypothesize four cognitive mechanisms through which contextual entropy could impact RTs—three of which we are able to design experiments to analyze. Overall, our results support a view of reading that is not just responsive, but also anticipatory.1
Wrapping Up 1QM
Authors: Johnson Michael B.
Published: December 2023

This article evaluates the debated placements of fragments in the reconstruction of the War Scroll from Cave 1 (1QM). There are three fragments (frags. 3, 9, 10) and one large fragment cluster (1QM 2, 8, DSSHU pl. 34; 1Q33 2) that are contested in 1QM scholarship. These placements are important for establishing the text of 1QM and the determination of whether there was another War Scroll from Cave 1 among the fragments assigned to 1QM and 1Q33. I will evaluate the remaining debates about fragment placements in 1QM, focusing especially on Hanan and Esther Eshel’s proposal (2000) that the large fragment cluster is not part of 1QM but is the remnant of a different scroll, which they label 1QMa. To assist in weighing the plausibility of fragment placements in 1QM, this article incorporates 3D visualizations of how 1QM would appear in a rolled state to demonstrate how well some proposed fragment placements cohere with the scroll’s damage patterns.
Diversity of symbiotic bacteria in the digestive and circulatory systems of lobster and crayfish: important connections for efficient aquaculture. A systematic review
Authors: Oliveira Ana V. da S. , Vieira Jhones de L. , Maia Hudson D. , Gaeta Juliana , de Sousa Oscarina V. , da Silva Jéssica L. S. , de Menezes Francisca G. R.
Published: December 2023

Lobsters and crayfishes have social, economic and ecological significance in several regions around the world. These crustaceans have complex digestive systems and open circulatory systems colonized by symbiotic microorganisms that play essential roles in the health, nutrition and disease of crustaceans, attracting considerable interest. The importance of the microbiota for the successful cultivation of animals in captivity is known, however, there is a lack of information about the symbiotic microbiota in different species of lobsters. The aim of this study was to summarize global information on microbiota studies of anatomical sites of lobsters and crayfishes looking for patterns of bacteria that colonize their intestine, hepatopancreas and haemolymph. A systematic review was conducted using “Methodi Ordinatio”. Twenty-five significant articles, from 12 countries, were identified for analysis from the Scopus database. The crustacean genera found were Cherax, Pacifastacus and Procambarus (crayfish); Homarus, Nephrops and Panulirus (lobsters). The intestinal, hepatopancreas and haemolymph microbiota show a wide variety of bacteria influenced by infections affecting the individual, stress caused by changes in the environment, availability and quality of food, period of the year, stage of development and the animal’s sex, among other aspects. The common core bacterial microbiota among crustaceans consist of the genera Acinetobacter, Aeromonas, Candidatus Bacilloplasma, Candidatus Hepatoplasma, Citrobacter, Hafnia, Photobacterium, Pseudomonas, Shewanella and Vibrio. The results broadened our understanding of the microbiota in the intestinal and circulatory systems of crustaceans, the flaws for and needs for standardization of analysis techniques, and the use of a multi-specialized approach for the protection and management of lobsters as a fisheries resource.
First record of the pebble crab, Liagore rubromaculata (De Haan, 1835) (Decapoda, Brachyura, Xanthidae) from the west coast of India
Authors: Sureandiran B. , Dave T. H. , Solanki J. B. , Karuppasamy K. , Suyani N. K. , Vidhya V.
Published: December 2023

A single male specimen of the pebble crab, Liagore rubromaculata (De Haan, 1835) measuring 40.0 × 27.0 mm (CW × CL) was observed and is recorded for the first time from the west coast of India. The species was identified by the presence of a smooth and unarmed anterolateral margin. Globally, the species has been reported from the waters of Australia, South China, Indonesia, the Persian Gulf, and the Bay of Bengal, but no report is available from the Arabian Sea. Hence the present study bestows the first confirmed record of L. rubromaculata from the Arabian Sea along the west coast of India, provided with a detailed taxonomic description of the species.
Basculing in elite show jumping horses: a motion analysis study of trunk and neck movement
Authors: Fercher C. , Reiser M. , Müller H. , Joch M. , Maurer H.
Published: December 2023

The movement of the trunk and neck plays a crucial role in training and assessing the technical performance in show jumping horses. The term ‘bascule’ describes a rounded and harmonious jumping movement characterised by an arched or bulged back and a lower, stretched neck position. However, there is a lack of consensus in the literature regarding the specific kinematic features that define basculing. The question remains whether the impression of a rounded back is the result of spine flexion into an upward curved position or a combination of thorax elongation and a downward movement of the neck. Additionally, the timing of these movement components remains unclear. To address these questions, we conducted kinematic analyses on six ridden show jumpers with varying levels of competition experience. Using a simplified kinematic model, we analysed the trajectories of the trunk length, trunk height, neck length, and trunk-neck angle throughout different phases of a jump over a single 130 cm vertical fence during a training session. Furthermore, we explored potential differences in basculing execution based on the horses’ competition levels. Our findings indicate that the horses’ body posture while jumping over the fence does not exhibit true flexion of the thoracolumbar spine, resulting in an upward arched shape of the spine. Instead, during the take-off phase, the trunk shows elongation, suggesting a reduced curvature of the spine in this region, accompanied by a downward movement of the neck. However, we consistently observed a shortening of the neck segment, indicating flexion of the cervical spine. Correlation analyses suggest that these changes are associated with the horses’ level of competition, with more pronounced basculing observed in horses with higher competition levels.
Mussolini’s Cesare
Authors: Gaborik Patricia
Published: December 2023

This article discusses the collaboration between Benito Mussolini and Giovacchino Forzano in the writing of three historical dramas, focusing on the third text of their collaboration, Cesare, which dates to 1939. Placing this partnership within the context of Fascism’s broader theatrical programming, the essay discusses the play as a model of Fascist theater, for its imparting of Fascist ideological tenets, propagandistic messages, and pedagogical aims. It focuses in particular on the ways in which the play uses the analogy between ancient Rome and Fascist Italy, and between Julius Caesar and Mussolini, embodying fascism’s poetics of history, contributing to the anthropological revolution, and overall demonstrating the ‘new fascist man’ through the character of Caesar/Mussolini.
The Classical Performances at the Temples of Agrigento and Paestum (1928–1938)
Authors: Troiani Sara
Published: December 2023

This article surveys and analyzes classical performances staged between 1928 and 1938 in the archeological areas of Agrigento and Paestum, and underlines similarities and differences between them to evaluate the impact of Fascist ideology on their organization. Indeed, these performances were much more concerned with staging ancient poetry recitations, pantomimes, choreographies, and parades rather than entire plays, as these were effective conduits for Fascism’s visual aesthetics, which was aimed at enhancing the archeological settings that hosted them. The events organized in Agrigento were meant to extend the presence of classical performances in ancient theaters and monuments other than Syracuse under the supervision of the National Institute of Ancient Drama (INDA) and other national and international artists, while the performances staged in Paestum were intended to promote international tourism in Italy, which included the programmatic restoration and renovation of ancient monuments.
Christian Arabic Theological Works: Copyists and Author’s Endings and Self-abasement
Authors: Portillo Rocio Daga
Published: December 2023

This article analyzes author’s endings and copyist’s colophons in theological works, especially from tenth-century Syro-Palestine and Egypt. A tentative typology and a comparison of Christian and Islamic colophons is also provided. Self-abasement, seeking God’s forgiveness, and prayers from the reader are features derived from the monastic tradition in the Greek, Syriac and Coptic languages before they became characteristic of Arabic colophons of Christian works. Moreover, the apologetic language of Christian works varies according to historical circumstances. While Abū Qurra, in the Syro-Palestine region, wrote a strong apologetic colophon in a time of mass conversions, Sāwīrus b. al-Muqaffaʿ, under the tolerant Fāṭimid rulers, takes a less apologetic approach. Islamic colophons render similar formulas of self-abasement, mostly using the vocabulary of Sufism. The extent of this usage needs further research, however. The printing press put an end to religious formulas and self-abasement, due to the influence of the secularized milieu of Western Europe.
Resisting Closure, Defying the System: Two Dystopian Novels from Egypt
Authors: Bešková Katarína
Published: December 2023

During the past decade, the Egyptian literary scene witnessed the rise of dystopian novels. Even though the emergence of this genre stems mainly from the overall socio-political conditions and the general atmosphere of oppression in the country, this phenomenon has often been interpreted in terms of the disappointing results of the 25th January revolution in 2011. Since dystopias generally paint a bleak picture of society, they are often believed to reflect a rather pessimistic view of their authors. However, according to R. Baccolini and T. Moylan’s theory of critical dystopia, a utopian impulse and hope for better tomorrows can be preserved in dystopias through an open ending. While knowledge of history together with access to personal and collective memories and gaining control over means of language all play a crucial role in dystopian resistance against the hegemonic order and its narratives, it is the absence of closure that opens up the possibility for the opposition to succeed. The aim of this paper is to analyse two contemporary critical dystopias from Egypt, namely Aḥmad Nājī’s Istikhdām al-ḥayāt and Basma ʿAbd al-ʿAzīz’s al-Ṭābūr, with regard to Baccolini and Moylan’s theory and to show how the absence of closure in these literary works can help defy the oppressive system. Since an open ending invites readers to finish the story on their own, it can even call them to action. That being the case, the paper argues that these critical dystopias are at their very heart not as pessimistic and defeatist as first impressions might suggest.