bluuebunny/crossref_metadata_2025 huggingface dataset:
Functioning of a higher educational institution under force majeure circumstances: A case study of Ivan Franko National University of Lviv
Authors: Kaplenko Halyna , Kulish Inna , Hrabovetska Olha , Stasyshyn Andrii , Dubyk Viktoriia
Published: April 2023

Over the last decade, Ukrainian higher educational institutions have faced extraordinary and even dire circumstances three times: russia’s attack on Ukraine in Donbas and occupation of Crimea (2014); a total lockdown caused by a pandemic due to the spread of the coronavirus disease (COVID-19) (2020); russia’s full-scale war against Ukraine (2022). Each time, Ukrainian higher educational institutions had to reformat the educational process to meet the challenges of the time. Lviv region began accepting internally displaced people from Donbas and Crimea in 2014. In this regard, Ivan Franko National University of Lviv (Lviv University) has established itself as one of the regional leaders. The spread of the COVID-19 pandemic required the immediate organization of distance learning and, therefore, the improvement of information and technical support. russian crimes against humanity in 2022 caused an enormous wave of internal displacement of citizens. Employees and students of Lviv University have been helping internally displaced people with housing, food, and basic necessities since the beginning of the full-scale war; they have also assisted refugees at checkpoints along the Ukrainian-Polish border. Over a hundred University students and employees serve in the Armed Forces of Ukraine. Those who remain at home work hard to bring victory over the enemy closer. They are volunteering, fundraising, arranging humanitarian aid, cooperating with international charitable organizations, etc.Under difficult wartime conditions, the University’s academic community continues to fulfil its primary mission: to provide modern, high-quality education.
A university displaced twice: Irreversible and erroneous losses of human capital
Authors: Zakharova Oksana , Prodanova Larysa
Published: April 2023

Due to russian military aggression in Ukraine, two waves of relocating educational institutions from occupied and dangerous territories have occurred over the past nine years (in 2014 and 2022). In the first place, relocation affected those universities that were based in industrial regions before the war and trained professional personnel for large industrial enterprises. The speed of the country’s post-war recovery will depend on the availability of professional specialists able to restore industrial enterprises’ functioning. Therefore, it is necessary to highlight the changes in the human capital of displaced universities due to relocation. The aim of this study is to assess the losses of human capital the displaced universities suffered due to russian military aggression. Using the example of Donetsk National Technical University, which has been relocated twice, the study illustrates the stages in which the organizational structure of one of the university’s divisions changed and the number of teachers decreased in 2014–2023. The study describes the key features of the first and second displacement waves and their implementation specifics. The survey of the resigned teachers demonstrated the losses of human capital experienced by the university over nine years. The benefits for those Ukrainian universities which have hired displaced teachers are exemplified. The results of this study indicate that the experience of displaced universities should be scrutinized at the ministerial level and used to develop strategies for restoring the human capital of the displaced universities and further accumulating human capital in Ukrainian higher education.
ATR-FTIR AND UV-VIS AS TECHNIQUES FOR METHANOL ANALYSIS IN BIODIESEL-WASHING WASTEWATER
Authors: dos Santos Tiago , da Silva Rúben , da Costa Fabioney , Sousa Demétrio
Published: April 2023

Methanol present in wastewater from the biodiesel industry can become an atmospheric pollutant and an environmental liability of effluents. This article proposes the development and performance evaluation of two spectroscopic methods, ATR-FTIR and UV-Vis, to identify and quantify methanol in aqueous media. The results of both ways exhibited remarkable linear detection, with a coefficient of determination (r2) > 0.99, wide working range, and relative standard deviation (RSD) < 12%. In the ATR-FTIR method, the detection and quantification limits were 0.064 and 0.128% m V-1, respectively. The UV-Vis method presented lower limits (0.005 and 0.008% m V-1, respectively). Finally, the methods were successfully applied to quickly and sensitively quantify the methanol present in wastewater from biodiesel-washing in a wide concentration range of 0.008-0.641% m V-1. Therefore, we evidenced the feasibility of spectroscopic methods in quality control for identifying and quantifying methanol in aqueous solution, with potential for application in biodiesel production industries and research laboratories. Mainly by ATR-FTIR, in the region of 1300-900 cm-1, as it proved to be more environmentally friendly, faster, and cheaper than the GC-FID method.
Discrete sliding mode control method for particle swarm optimization-based brushless DC motor of electric vehicle
Authors: Wang Fei , Mei Qiongzhen , Xin Xiaolei
Published: April 2023

Brushless DC motor (BLDCM) is a multivariable nonlinear time-varying system, which is difficult to control. The discrete sliding mode control method for BLDCM of electric vehicle on the basis of particle swarm optimization (PSO) is studied to improve the application of BLDCM in electric vehicle. The mathematical model of BLDCM of electric vehicle is established using the state formula. Based on the mathematical model of BLDCM, through the analysis of electromagnetic torque control of BLDCM, it is clear that controlling the angle between rotor flux and stator flux can accurately control the electromagnetic torque of BLDCM. The adaptive discrete sliding mode controller (SMC) is set to control the electromagnetic torque of BLDCM of electric vehicle, and the PSO algorithm is adopted to obtain the optimal parameters of the adaptive discrete SMC to realize the discrete sliding mode control of BLDCM of electric vehicle. According to experimental results, the proposed method can achieve the accurate control of torque and speed of BLDCM of electric vehicle, and increase the application of BLDCM in electric vehicle.
Hydrological assessment of the Tungabhadra River Basin based on CMIP6 GCMs and multiple hydrological models
Authors: Rudraswamy G. K. , Manikanta Velpuri , Umamahesh Nanduri
Published: April 2023

Climate change significantly impacts the natural systems, accelerating the global water cycle, and impacting various ecosystem services. However, the expected effects of climate change on the frequency and severity of extreme events on hydrological systems vary significantly with location. The present study investigates the uncertainties engulfed in hydrological predictions for the Tungabhadra River Basin. The ensemble streamflow projections were generated using four hydrological models, five climate models, and four climate scenarios to illustrate the associated uncertainties. The uncertainty in hydrological components such as streamflow (QQ), water availability (WA), and potential evapotranspiration (PET) was analysed in the future period (2015–2100). The results suggest that, in the monsoon period, precipitation projections increase by about 10.43–222.5%, whereas QQ projections show an increment between 34.50 and 377.7%. The analysis of variance (ANOVA) technique is used to further quantify the contribution of different sources to the total uncertainty. Furthermore, the ensemble spread is optimized using quantile regression forests (QRF), and the post-processed flows are likely to decrease up to 7% in June and increase up to 70% in September. This study is envisaged to give insights into the quantification of uncertainties in the prediction of future streamflow for rational and sustainable policymaking.
Multifractal analysis of malaria cases in India in a global warming scenario
Authors: Dwivedi Suneet , Chaturvedi Shweta
Published: April 2023

An effort is made to evaluate the multifractal properties of malaria cases in India from 1980 to 2014. The possible changes in these properties in a global warming scenario (during 2015–2049) are also quantified. The malaria cases for this purpose are derived from the VECTRI dynamical malaria model, which uses rainfall and temperature data of Coupled Model Intercomparison Project Phase 6 models for the historical and SSP5–8.5 projection scenario, respectively. It is found that the generalized Hurst exponent h (q) and multifractal spectrum width Δα are strongly nonlinear decreasing functions of order q, thus confirming the multifractal nature (and heterogeneous distribution) of the malaria cases in India. The multifractal spectrum of the malaria cases exhibits right-tailed nature along with high inter-model variability, suggesting that the time series under consideration are fine scale and highly complex in nature. The multifractal spectrum width and change in singularity dimension are used to quantify the strength of multifractality for the historical and future projection scenario. It is demonstrated that the strength of multifractality of malaria cases is likely to decrease with an increase in greenhouse gas concentration, which may be happening due to a persistent increase in malaria cases in India as a result of global warming.
Flood mitigation of Bila River in Sidrap Regency Indonesia based on eco-drainage retention pond
Authors: Suleman Abdul Rivai , Badaruddin Sugiarto , Mustamin Mustamin , Saing Zubair , Mustamin Muhammad Rivaldi
Published: April 2023

This study aims to analyze the distribution of floods in the Bila River and its countermeasures in reducing the impact that occurred in Sidrap Regency. The study performs hydrological analysis using the Bila watershed rainfall data, calculates the planned flood discharge using the HSS Soil Conservation Service (SCS) model, and simulates the flood flow profile using the HEC-RAS 2D numerical model. It is found that the Q20 flood discharge of the Bila and the Bulucenrana Rivers entered the Bila River downstream calculated from the HSS SCS analysis are 738.60 and 779.50 m3/s, respectively. The overflow of the Bila River flood affects nine villages, namely Kalola Village (0.06 km2), Sogi Village (0.01 km2), Kalosi Alau Village (0.32 km2), Kampale Village (0.11 km2), Salomalori Village (0.42 km2), Tanru Tedong Village (2.12 km2), Kalosi Village (0.91 km2), Salobukkang Village (1.70 km2), and Taccimpo Village (4.01 km2). It is proposed that the best solution to deal with the issue is by introducing an eco-drainage system, namely by constructing a retention pond with a maximum storage volume of 3.81 million m3 or with a normal storage of 2.4 million m3. The existence of a retention pond can reduce the inundated area around 8.28 km2 or 85.71%.
Risk-based decision-making systems in water and food security of global drylands
Authors: Wang Manman , Du Yiming , Jiang Tianlong
Published: April 2023

This study introduces the foundational principles behind the water footprint in water and food security for evaluating the managerial strategies of agricultural water management in arid areas. The role of green, grey, blue and white water footprints in yield production has been critically investigated to analyze the climate and economic risks. Therefore, a nonlinear hydro-economic framework, which integrates soil water content, food production and economics has been used for the semi-arid regions of China. Non-dimensional form of net benefit per drop was formulated to analyze the uncertainty of economic parameters. Root zone moisture was simulated to estimate crop yield, transpiration, evaporation, water required for irrigation and increase water quality. Five plants of potato, onion, tomato, eggplant and carrot were selected due to similarity in the plant growth season and market criteria. The results showed that the average effective rainfall contributed less than 15% to food production. The impact of the risk of economic fluctuations in achieving the expected net profit has been more than water.
Géneros de foraminíferos bentónicos en zonas mesofóticas superior y media del Parque Nacional Natural Corales de Profundidad y su potencial como bioindicadores de hábitats y cambios ambientales
Authors: Henao Castro Alejandro , Navas S. Gabriel R.
Published: April 2023

Los arrecifes coralinos mesofóticos hacen parte del objeto de conservación del Parque Nacional Natural Corales de Profundidad (PNNCPR). Un paso fundamental para el manejo de un área protegida es la caracterización de su riqueza específica, y uno de los grupos taxonómicos importantes en ambientes arrecifales son los foraminíferos bentónicos. Debido a que no existen investigaciones de este tipo para el PNNCPR, se consideró estudiar los géneros de foraminíferos bentónicos de las zonas mesofótica superior y media, y explorar una posible relación de dicha composición con sus ámbitos geográficos y batimétricos, así como con cambios ambientales. Los resultados permitieron concluir que una submuestra de 50 individuos con conchillas en buen estado, tomadas de diez muestras de 10 g, fue suficiente para estimar la composición de géneros presentes en la zona. La riqueza de géneros encontrada fue de 53, siendo Amphistegina, Quinqueloculina y Triloculina los que presentaron mayor frecuencia de aparición. No se encontraron diferencias significativas entre el conjunto de géneros de foraminíferos bentónicos de los estratos de profundidad superior (34-60 m) y medio (61-90 m). El conjunto de foraminíferos bentónicos del sector Bajo Calamarí difiere significativamente del encontrado en la localidad de Bajo Frijol. El análisis conjunto de la similaridad de muestras mediante clasificación y ordenación permitió identificar tres grupos congruentes con el sitio de muestreo, la época del año y el año de recolecta. El grupo de foraminíferos heterótrofos (Quinqueloculina, Triloculina, Cibicides, Discorbis, Rosalina, Poroeponides y Textularia) fue el más frecuente, seguido por el de los foraminíferos simbiontes (Amphistegina) y oportunistas (Elphidium). Los resultados obtenidos permiten sugerir que los foraminíferos bentónicos mesofóticos tienen potencial de ser bioindicadores para el programa de monitoreo del PNNCPR.
Variances in the Expression Profile of DUSP1-7 and miRNAs Regulating
their Expression in the HaCat Line under LPS and Cyclosporine A
Authors: Dąbala Maciej , Świder Magdalena , Kasela Tomasz , Buda Paulina , Grabarek Beniamin Oskar
Published: April 2023

Introduction:

Cyclosporin A (CsA) treats moderate to severe psoriasis vulgaris. Psoriasis
is a chronic inflammatory disease in which hyperproliferation of keratinocytes occurs. One of
the most relevant signaling cascades in the development of psoriasis is the mitogen-activated protein
kinase (MAPK) signaling pathway. It has been observed that dual-specificity phosphatases
(DUSPs) dephosphorylate signaling molecules, such as MAPKs.

Aims:

This study aims to determine changes in the expression pattern of Dual Activity Protein
Phosphatase (DUSP1-7) and micro RNAs (miRNAs), potentially regulating their expression in the
human adult, low-calcium, high-temperature keratinocytes cell line (HaCaT) cultures exposed to
lipopolysaccharide A (LPS)-induced inflammation, followed by CsA.

Methods:

HaCaT cell line was exposed for 8 hours to 1 μg/mL LPS and then to 100 ng/mL CsA
for 2, 8, and 24 hours compared to cultures not exposed to LPS and the drug. The molecular analysis
included determining the DUSP1-7 expression and the miRNAs potentially regulating it using
an expression microarray technique. An enzyme-linked immunosorbent assay (ELISA) was also
performed to assess the concentration of DUSP1-7 in the culture medium. Statistical evaluation
was performed assuming a statistical significance threshold (p) of < 0.05.

Results:

Statistically significant differences were found in the expression of DUSP1-7 mRNAs
and the miRNAs that regulate their expression. The most significant changes in expression were
observed for DUSP1 and DUSP5, with the differences being most pronounced during the eighthour
incubation period of the cells, with the drug predictive analysis showing that miR-34 potentially
regulates the expression of DUSP1-4,7, miR-1275: DUSP2, mir-3188: DUSP4, miR-382:
DUSP4, miR-27a and miR-27b: DUSP5,6 and miR-16: DUSP7. No expression of DUSP1-7 was
demonstrated at the protein level in CsA-exposed cultures.

Conclusion:

Our evaluation of the efficacy of CsA therapy on an in vitro model of HaCaT indicates
that treatment with this drug is effective, resulting in changes in the expression of DUSP1-7
and, potentially, the miRNAs that regulate their expression. We also confirmed that the different
expression pattern of mRNA and protein encoded by a given transcript is not only due to the regulatory
role of miRNAs but also the lack of synchronization between transcription and translation
processes.
Delivering Relaxin Plasmid by Polymeric Metformin Lipid Nanoparticles
for Liver Fibrosis Treatment
Authors: Li Yujie , Ma Lisha , Xiong Yang , Shi Jingbin , Zhang Feifeng , Chai Qian , Hu Gengshan , Liu Yun
Published: April 2023

Background:

Liver fibrosis usually progresses to liver cirrhosis and even results in hepatocellular
carcinoma, which accounts for one million deaths annually worldwide. To date, anti-liver fibrosis
drugs for clinical treatment have not yet been approved. Nowadays, as a natural regulator, Relaxin
(RLX) has received increased attention because the expression of RLX could deactivate the activation
of hepatic stellate cells (aHSCs) and resolve liver fibrosis. However, its application in treatment is limited
due to the short half-life in circulation and low accumulation within the target organ.

Methods:

To address these problems, a kind of polymeric metformin (PolyMet)-loaded relaxin plasmid
(pRLX) core-membrane lipid nanoparticle (PolyMet-pRLX-LNPs, PRLNP) was prepared. Here,
PolyMet was used as a carrier to replace the traditional polymer polyethylene diene (PEI), which is of
higher toxicity, to prolong the circulation time of pRLX in vivo. Then, the antifibrotic ability of PRLNP
to overcome liver fibrosis was carried out in C57BL/6 mice. It is worth mentioning that this is the first
time to investigate the potential of PRLNP in carbon tetrachloride-induced liver fibrosis.

Results:

The results showed that PRLNP effectively downregulated fibrosis-related biomarkers such as
alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Meanwhile, histopathological
examinations also showed low collagen accumulation, revealing that PRLNP could histologically and
functionally alleviate liver fibrosis. In addition, no significant difference in serum biochemical value
between the PRLNP and the normal group, suggesting the safety profile of PRLNP.

Conclusion:

This research proposed a novel non-toxic treatment method for liver fibrosis with a nanosystem
to effectively treat liver fibrosis.
Evaluation of Systolic Function using Global Longitudinal Strain in Isolated
Obese and Overweight People
Authors: Bayat Fariba , Khani Mohammad , Hooshmand Elham
Published: April 2023

Background:

The association of obesity with left ventricular (LV) diastolic dysfunction
is fully understood, but there are few investigations regarding its effect on LV systolic function in
the absence of other risk factors. This study aimed to identify the global longitudinal strain (GLS)
changes in isolated overweight and obese people in the absence of other risk factors.

Methods:

A total of 120 individuals, including 60 obese, 30 overweight, and 30 healthy controls
with no underlying disease and no history of hypertension, diabetes, CAD, or CKD were included in
the study. Echocardiographic findings were measured, including apical 2-, 3- and 4-chamber GLS,
GLS total, LV diameter, interventricular septum thickness, and PAP. These findings were then
compared between the three groups (obese, overweight, and normal controls).

Results:

Analyses showed that LV diameter in healthy controls was significantly lower compared to
overweight (p = 0.02) and obese (p < 0.0001) participants. Also, the interventricular septal thickness
was significantly increased in overweight (p = 0.007) and obese (p < 0.0001) individuals compared
to healthy controls. The mean and standard deviation (Mean ± SD) of total GLS values were -
22.29% ± 1.89% for normal weight, -22.09% ± 1.91% for overweight, and -19.88% ± 2.34% for
obese individuals. The total GLS of obese participants was significantly lower than overweight and
normal controls (p < 0.0001). It was observed that the GLS values were significantly lower in people
with BMI higher than 40. The mean ± SD of total GLS values were -20.68% (1.84%) for BMI ≤
40 patients and -18.51% (2.52%) for BMI > 40 patients.

Conclusion:

Data revealed that all GLS values had a moderately strong correlation with BMI values.
Also, subclinical LV dysfunction was detected in overweight and obese subjects.
The Impact of Illness Perception on Delay in Seeking Medical Help in Patients with Acute Chest Pain: A Cross-sectional Study in the United Arab Emirates
Authors: Mosleh Sultan M. , Alnajar Malek K. , Darawad Muhammad
Published: April 2023

Background:

The concern of contracting COVID-19 has prevented numerous individuals with ambiguous myocardial infarction symptoms from seeking medical attention, leading to delayed presentation and treatment of acute coronary syndrome (ACS). This delay could increase the risk of long-term consequences.

Aim:

The aim of this study is to evaluate the impact of illness perception on delay in seeking medical help in patients with acute chest pain in UAE during COVID-19 pandemic.

Methods:

A descriptive cross-sectional design was used.

Results:

A total of 222 in-patients participated in the study, with an average age of 54.3 years (SD=14, Range= 20-86). The average score of illness perception was 5.66 (SD=0.92), which indicates that CVD was perceived as moderately threatening to physical and emotional status. Univariate analysis showed that illness coherence having previous cardiac catheterization, diabetes and asthma were factors associated with delay in seeking medical services. The linear regression showed that college education was a strong predictor of delay, while a history of asthma and undergoing cardiac catheterization were independent predictors of shorter delay.

Conclusion:

Illness coherence perception and time of seeking medical help are correlated. In addition, illness perception of personal control is low, which indicates the need for educational intervention. Other clinical factors also impact patients’ decisions, such as previous cardiac intervention and comorbidity, highlighting the target group for further attention from the healthcare team.
Evaluation the Effect of Chronic Obestatin Therapy on the Serum Glucose, Insulin And Lipid Levels in Type 2 Diabetic Rats
Authors: Al-Halbouni Safa , Homsi Shadi , koshji Nabil
Published: April 2023

Background:

Diabetes mellitus (DM) is one of the most common health disorders, which has become increasingly common in recent years. Type 2 diabetes affects about 90-95% of all diabetic patients, and is often associated with obesity and insulin resistance in most patients. The medical treatment aims to reduce insulin resistance and increase the production of insulin by pancreatic β-cells.

Obestatin is a new hormone encoded by the Preghrelin gene. Obestatin is an anorexic hormone that reduces food intake. It has also been shown to play an important role in regulating glucose and lipid levels in the blood.

Study Aim:

Our study aims to evaluate the therapeutic benefit of obestatin in rats with experimental type 2 diabetes in reducing blood glucose and improving insulin levels, and its effect on insulin resistance, TG, TC and pancreatic β-cell survival.

Methods:

A total of 30 male Wister rats (150 -200g) were randomly divided into three groups: group I (control group), group II (T2DM group) induced by administration fructose solution 10% for 14 days, and single injection IP of streptozotocin (STZ) (35 mg/Kg), group III (T2DM treated with obestatin) (25 μg/kg) IP twice daily for 30 days. Blood samples were collected at the end of the experiment by terminal intracardiac sampling for bioassays to estimate fasting glucose, insulin, triglyceride (TG), total cholesterol (TC), and assessment of HOMA-IR. Body weight was also measured. Mean ± STD was calculated. The statistical significance of differences across the groups was determined by one-way ANOVA followed by a post Hoc Turkey’s test. The differences were considered significant at 0.05˃P.

Results:

After 30 days of obestatin treatment, the diabetic group showed a significant increase in glucose, TG, TC and HOMA-IR values and a significant decrease in insulin levels compared to the control group. In comparison, the obestatin-treated group of diabetic patients showed a significant decrease in glucose, TG and TC levels, with a slight increase in the insulin level compared to the diabetic group. In addition, the histological study (H&E) of isolated pancreatic tissue from the second group showed deformed, shrunken Langerhans islets with significant loss of their β- cells, and some cells with vacuolated cytoplasm. Moreover, the histological features of the treatment group were somewhat similar to those of the control group.

Conclusion:

The results of our study showed the efficacy of obestatin as a treatment in reducing the levels of all glucose, triglycerides and total cholesterol in the blood to normal limits in induced experimental rats with type 2 diabetes. Moreover, the improvement of insulin levels in the blood, and the results of the histological study showed an improvement in the size of the islet and an increase in the number of β-cells. Thus, obestatin can be used as a promising target in the treatment of metabolic diseases such as diabetes and obesity.
A Novel Approach to Cervical Cancer Therapy: A Short Review
Authors: Mozaffari Nejad Amir Sasan , Kamarehei Farideh , Khodavirdipour Amir , Mehrbod Parvaneh , Alikhani Mohammad Yousef
Published: April 2023

Cervical cancer is one of the most common cancers affecting women worldwide, and it occurs following persistent infection. Cervical cancer incidence is tightly linked to HPV infection (human papillomavirus), and particularly, type 16 and type 18 viruses cause the majority of cases. The common therapies for cervical cancer include surgery, chemotherapy, and radiation therapy, which are often invasive or unbearable treatment methods with many side effects. They just probably slow down the disease progression or alleviate any comorbid conditions, including vaginal bleeding and pain, which is called palliative care, while novel treatment approaches, especially virus-like particles and viral oncolysate, could eliminate these complications. In this review study, we have proposed a novel approach to cervical cancer therapy focused on utilizing Newcastle disease virus as viral oncolysate with a high potential of immunity induction and low side effects. Furthermore, we have attempted to shed some light on the perspectives of novel virus-based cervical cancer immunotherapy. Finally, we review the recent findings from basic and clinical studies and also discuss the usefulness and limitations of this approach, as well as the reasons why it is believed that viral oncolysate immunotherapy may be of relevance in the treatment of human cervical cancer.
Study of "Green Manufacturing" on Rural Crystal Coconut Sugar SMEs
Authors:   Universitas Nahdlatul Ulama Purwokerto, Syska Kavadya , Ropiudin Ropiudin ,   Universitas Jenderal Soedirman
Published: April 2023

Crystal coconut sugar production will produce waste which will have an impact on environmental pollution. Waste generated is liquid waste and solid waste. Waste reduction handling can applied to "green manufacturing" principle. Research aims are: (1) identify waste generated, (2) determine green manufacturing opportunities, (3) green manufacturing opportunities analyze feasibility, and (4) green manufacturing implementation determine priority. Research phase includes: (1) quick scan analysis, (2) material, energy and waste flows identification, (3) alternative green manufacturing opportunities, (4) feasibility analysis (financial, technical and environmental), and (5) determination green manufacturing implementing priority. Results showed that ant sugar production produces waste in excrement on sap form, ashes from combustion, energy loss, crystal nuclei, and spilled sugar. Green manufacturing alternatives that are technically, environmentally and financially feasible are ash into inorganic fertilizers utilization, replacing cooking furnace, modifying drying equipment, replacing process materials, repairing and modifying screening, drying and packaging equipment. Implementing green manufacturing priority alternatives indicates that main alternatives to implemented are repairs and screening, drying and packaging equipment modifications which are considered technical and technological capabilities good in criteria, finance, human resources (HR), and environment. These results indicate that "Green Manufacturing" in rural SMEs crystal coconut sugar to increase global competitiveness "Green Economy".
Respon dan Akurasi Sensor Gas MOS (MQ-Series Module) Dalam Mengidentifikasi Minyak Nilam (Patchouli Oil)
Authors:   Universitas Jenderal Soedirman, Kuncoro Purwoko Hari , Sudarmaji Arief ,   Universitas Jenderal Soedirman, Sulistyo Susanto Budi ,   Universitas Jenderal Soedirman, Wijaya Krissandi ,   Universitas Jenderal Soedirman, Margiwiyatno Agus ,   Universitas Jenderal Soedirman
Published: April 2023

Dalam penelitian ini dilakukan pengujian terhadap sensor gas MOS tipe MQ (MQ-2.1, MQ-2.2, MQ-3, MQ-4, MQ-5, MQ-6 MQ-7, MQ-8, MQ-9, dan MQ-135) untuk mendeteksi kemurnian minyak nilam. Penelitian ini dilakukan dengan tujuan: 1) mempelajari respons sensor gas MOS tipe MQ dalam mengidentifikasi kemurnian minyak nilam, dan 2) mempelajari akurasi sensor gas MOS tipe MQ dalam mengidentifikasi kemurnian minyak nilam. Minyak nilam yang digunakan adalah minyak nilam pada berbagai tingkat pencampuran dengan minyak zaitun. Terdapat 2 jenis perlakuan yang diamati, yaitu: dengan pemanasan dan tanpa pemanasan. Pengukuran dilakukan terhadap nilai Baseline measurement (Ro) dan Atsiri measurement (Rg) guna menentukan nilai sensitivitas sensor (S). Selanjutnya nilai Rg dan S digunakan untuk membuat grafik loading plot berdasarakan metode PCA (Principal Component Analysis) untuk menentukan respon individu setiap sensor. Tingkat akurasi sensor dalam mendeteksi minyak nilam ditentukan berdasarkan: identifikasi minyak nilam menggunakan grafik score plot, klasifikasi data menggunakan metode COG (Center of Gravity) dan ED (Euclidean Distance), serta penghitungan akurasi. Dari kesepuluh sensor gas yang diujikan, terdapat 2 sensor yang memberikan respon rendah yaitu MQ-3 dan MQ-7. Sedangkan 8 sensor yang lain memberikan respon yang baik dan relatif stabil, dengan respon tertinggi diperoleh dari sensor MQ-4. Rerata tingkat akurasi sensor yang dihasilkan pada nilai resistensi (Rg) lebih tinggi dibandingkan nilai sensitivitas (S), dan lebih tinggi pada perlakuan tanpa pemanasan dibandingkan perlakuan dengan pemanasan. Pada perlakuan tanpa pemanasan nilai rerata akurasi Rg dan S masing-masing adalah 88,79% dan 79,51%, sedangkan pada perlakuan dengan pemanasan masing-masing adalah 80,84% dan 74,52%.
Secularization Motives and Literary Changes in the Anrakguktaejajeonseung
Authors:   Korean Language & Literature, Xie Jie-juan
Published: April 2023

In this study, we looked at the changes that were seen when the Buddhist narrative Anrakguktaejajeon was passed down to the secular epic Anrakgukjeon. First, the background of the times and the motives of secularization were reviewed, and the literary aspects of secularized works were examined. Based on this, the meaning of secularization was reviewed. To summarize the discussion so far. First, the background of the times and the motives of secularization were examined. Anrakguktaejajeon appeared in the late Korea Dynasty and early Joseon Dynasty. This was the era when Buddhism lost its status as a national religion and Confucianism gained power and eventually grew into the ruling ideology. Therefore, the Buddhist world chose propagation as a way to overcome the crisis, and as a means of propagation Anrakguktaejajeon. Due to its religious purpose, this work could be restructured at any time because the causality of the narrative was not close. It is Anrakukjeon that makes up for the deficiencies in the secular aspect. Second, the literary aspects following secularization were identified by dividing them into structure and ideology. In terms of composition, the spatial background has rationality, and the actions and results of characters have causality. On the other hand, it was restructured to make the story before and after the case inevitably. In terms of ideology, Buddhist content was used as a means to shape the story, and secular persuasion was secured by introducing Confucian ideology. In addition, it also followed the universal method of shaping novels at the time by converging Taoist thought. Third, the literary value and significance seen through secularization were reviewed. Through the change of Anrakguktaejajeon to a classic novel, which is a secular narrative, it is possible to rationally trace the process of transition from a novel to a novel, as well as to identify what aspects of the sacred narrative were added and subtracted to create the character of a secular narrative. In addition, it should be noted that this work can contribute empirically when understanding the diachronic context of Korean classical novel history.
The Study of Taxonomic Affinity in 7 Species of Asteraceae Family Based on Morphological Characters
Authors: Nahdloh Elfa Dina Rahmah , Hermawan Lutfi Adi , Akmalia Hafidha Asni , Adawiyah Putri Rabiatul
Published: April 2023

Morphological characters are important characters in determining plant relationships. This study aims to analyze the phenetic relationship of the 7 member of Asteraceae family based on morphological characters. The study was conducted in May – July 2022. We used 7 species of Asteraceae including Ageratum conyzoides L., Ageratum houstonianum Mill, Tithonia diversifolia (Hemsl.) A.Gray., Sonchus arvensis L., Erechtites valerianifolia (Link ex Spreng.) DC., Eupatorium odoratum L., and Tagetes erecta L. The equipment used were cameras, plant description books, and NTSYS software for taxonomic affinity analysis were used in this study. The results of the Asteraceae dendogram analysis showed that 2 clusters were formed, the first cluster containing the species Ageratum conyzoides L., Ageratum houstonianum Mill, Tagetes erecta L., Sonchus arvensis L., and Erechtites valerianifolia (Link ex Spreng.) DC., while the second cluster consisted of Tithonia diversifolia (Hemsl.) and Eupatorium odoratum L. The closest similarity coefficient of 0.8 was in the genus Ageratus in the first cluster and Tithonia diversifolia (Hemsl.) and Eupatorium odoratum L., in the second cluster. Based on this, it can be concluded that the morphological characters that influence the clustering of 7 species Asteraceae in this study are flower type, flower color, leaf base, leaf venation, leaf margin, and leaf color.
ASSESSING WORK PERFORMANCE PROVISIONS FOR PROMOTION OF CIVIL SERVANTS IN THE ERA OF DIGITAL SOCIETY
Authors: Febriyanto Satrio Alif , Dwiliandari Anggie Fauziah
Published: April 2023

Development of the distribution and information massification has increasingly occurred in a new social system supported by economic expansion, technology, and a global information system network. The high intensity of the use of technology in economic and socio-political activities is a sign of the birth of the era of digital society. As an actor with a significant position in government activities and development, it is appropriate for Civil Servants (PNS) to support the dynamics of developing a digital information society. As a generator of national and regional development, personnel assessment in the bureaucracy must adjust to the needs and demands of communicative-informative actions. The Study of the Relevance of Indicators of Performance Appraisal in The Advancement Provisions of Civil Servants in The Digital Society Era is intended to determine the role of civil servants in the development of digital society with the final result in the form of policy recommendations to optimize the role of civil servants in implementing digital society in the advancement aspect. The research method used is juridical-normative through literature studies and legislation relating to the State Civil Apparatus, employee affairs, and the digital society. Based on the research results, digital literacy is the key to optimizing the quality of bureaucratic resources in the era of the digital information society. Therefore, digital literacy needs to be used as an aspect in assessing the work performance of civil servants to accelerate the development of a digital society.
KALIMANTAN BORDER ISSUES AND INDONESIA'S BORDER DIPLOMACY TOWARDS MALAYSIA
Authors: Purnama Ari Bayu , Iswardhana Muhammad Ridha
Published: April 2023

This article aims to explain Indonesia's border diplomacy towards Malaysia regarding cross-border issues for the 2014-2020 period. In this case, there are often cases of disputes over territorial boundaries and social problems in border areas. To overcome this, Indonesia and Malaysia created the Malindo Social Security Cooperation (Sosek Malindo) and the Joint Indonesia Malaysia (JIM). This is following Indonesia's border diplomacy efforts which prove by the activities of annual meetings and sessions. The research method used a qualitative descriptive-analytical approach. The case analysis will explain the causes and effects of holding Indonesia-Malaysia border diplomacy based on secondary data. The author finds that various meetings and annual sessions of the two cooperation forums can resolve border disputes, illegal trade in goods and labor, and cross-border disputes related to the existence of Natural Resources. This research found that Indonesia-Malaysia border diplomacy in dealing with cross-border problems in 2014-2020 is carried out through the Malindo Social Security Cooperation (Sosek Malindo) and the Joint Indonesia Malaysia (JIM) cooperation. As a result, two segments of the national border were established at Simantipal River and Point C500-C600. Then in the case of PLBN development, Indonesia and Malaysia carried out border diplomacy through the Malindo Sosek Cooperation Forum in the form of the 35th and 37th meetings of KK/JKK Sosek Malindo and the 14th and 15th trials of Sekber KK/JKK Sosek Malindo.
STAKEHOLDER COLLABORATION IN THE DEVELOPMENT OF LOCAL HERITAGE IN LAMONGAN REGENCY
Authors: Febrianti Eni , Eprilianto Deby Febriyan
Published: April 2023

Local culture is a heritage nation that must be conserved even as it develops. Regency Lamongan is one place with a lot of relic culture. There is inherited culture in the form of tradition and relics very past highly crucial to maintain as well as develop Existence Thing the so research this goal for learning draft collaboration between stakeholders in developing local heritage Regency Lamongan This topic will be investigated using the descriptive qualitative technique with primary and secondary data collecting. The results of this study are known as the draft collaboration of one stakeholder with other stakeholders in developing local heritage in the district of Lamongan. Existence research is projected to have a substantial impact on the growth of local heritage in the middle modernization era.
Machine Learning Models for Blood Glucose Level Prediction in Patients With Diabetes Mellitus: Systematic Review and Network Meta-Analysis (Preprint)
Authors: Liu Kui , Li Linyi , Ma Yifei , Jiang Jun , Liu Zhenhua , Ye Zichen , Liu Shuang , Pu Chen , Chen Changsheng , Wan Yi
Published: April 2023

BACKGROUND

Machine learning (ML) models provide more choices to patients with diabetes mellitus (DM) to more properly manage blood glucose (BG) levels. However, because of numerous types of ML algorithms, choosing an appropriate model is vitally important.

OBJECTIVE

In a systematic review and network meta-analysis, this study aimed to comprehensively assess the performance of ML models in predicting BG levels. In addition, we assessed ML models used to detect and predict adverse BG (hypoglycemia) events by calculating pooled estimates of sensitivity and specificity.

METHODS

PubMed, Embase, Web of Science, and Institute of Electrical and Electronics Engineers Explore databases were systematically searched for studies on predicting BG levels and predicting or detecting adverse BG events using ML models, from inception to November 2022. Studies that assessed the performance of different ML models in predicting or detecting BG levels or adverse BG events of patients with DM were included. Studies with no derivation or performance metrics of ML models were excluded. The Quality Assessment of Diagnostic Accuracy Studies tool was applied to assess the quality of included studies. Primary outcomes were the relative ranking of ML models for predicting BG levels in different prediction horizons (PHs) and pooled estimates of the sensitivity and specificity of ML models in detecting or predicting adverse BG events.

RESULTS

In total, 46 eligible studies were included for meta-analysis. Regarding ML models for predicting BG levels, the means of the absolute root mean square error (RMSE) in a PH of 15, 30, 45, and 60 minutes were 18.88 (SD 19.71), 21.40 (SD 12.56), 21.27 (SD 5.17), and 30.01 (SD 7.23) mg/dL, respectively. The neural network model (NNM) showed the highest relative performance in different PHs. Furthermore, the pooled estimates of the positive likelihood ratio and the negative likelihood ratio of ML models were 8.3 (95% CI 5.7-12.0) and 0.31 (95% CI 0.22-0.44), respectively, for predicting hypoglycemia and 2.4 (95% CI 1.6-3.7) and 0.37 (95% CI 0.29-0.46), respectively, for detecting hypoglycemia.

CONCLUSIONS

Statistically significant high heterogeneity was detected in all subgroups, with different sources of heterogeneity. For predicting precise BG levels, the RMSE increases with a rise in the PH, and the NNM shows the highest relative performance among all the ML models. Meanwhile, current ML models have sufficient ability to predict adverse BG events, while their ability to detect adverse BG events needs to be enhanced.

CLINICALTRIAL

PROSPERO CRD42022375250; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=375250
Pengendalian Infeksi pada Pasien Kanker: Literature Review
Authors: Hanggoro Putro Dimas Utomo , Ike Darmayanti Anisa Rayu , Tandiola Rosdiana , Aulawi Khudazi
Published: April 2023

Latar Belakang: Kanker salah penyakit kronis yang mematikan di dunia. Upaya perawatan pasien kanker dilakukan untuk mencegah terjadinya komplikasi. Salah satu komplikasi yang sering timbul pada pasien kanker adalah infeksi. Perkembangan pengendalian infeksi berperan penting dalam kemajuan pengobatan kanker. Berbagai upaya dapat dilakukan untuk pencegahan dan pengendalian infeksi pada pasien kanker.Tujuan: Mengetahui tindakan-tindakan pengendalian infeksi pada pasien dengan kankerMetode: Systematic literature review menggunakan database Clinical Key dan Pubmed. Keyword yang digunakan Cancer Patient OR Chemoteraphy Patient AND Infection Control AND Reduce the spread of infectionHasil: Empat artikel memenuhi kriteria inklusi. Artikel yang dianalisis dipublikasikan pada tahun 2011‒2021. Metode dalam 1 artikel penelitian yaitu rancangan quasi eksperimen. Pengendalian infeksi pasien kanker yaitu kebersihan tangan, penggunaan APD, menempatkan pasien di ruang terpisah, pemilihan antibiotik & antifungal profilaksis pada keganasan hematologis, pengendalian lingkungan yang baik dan tepat, dan pemberian edukasi serta penerapan bundle pencegahan infeksi pada kateter.Kesimpulan: Kanker merupakan salah satu penyakit di mana pasien mengalami defisiensi imun dan merupakan sasaran utama berbagai penyakit infeksi sehingga memerlukan upaya untuk mengontrol infeksi pada pasien dengan kanker. Pengendalian infeksi pada pasien kanker yaitu kebersihan tangan, prinsip diet, Antibiotik and Antifungal Prophylaxis, Protective Environment, perlindungan isolasi, dan infeksi terkait kateter
ПЕРИФЕРИЙНЫЕ ДАТЧИКИ ДЛЯ СКАНИРУЮЩЕЙ ЗОНДОВОЙ МИКРОСКОПИИ
Authors: Терентьев А.Д. , Яминский И.В.
Published: April 2023

Сканирующая зондовая микроскопия дает информацию об изучаемых объектах с точ-
ностью до десятых и сотых долей нанометра при временном разрешении в миллисекунды и выше. Оснащение зондового микроскопа дополнительными периферийными датчиками для измерения температуры и влажности является полезной опцией. При изучении живых клеток необходимо контролировать и поддерживать концентрацию углекислого газа. Для этого необходимы компактные и удобные датчики углекислого газа с соответствующим программным интерфейсом, ориентированным на пользователя. При контролируемом перемещении образца, особенно при использовании больших полей обзора, важными аксессуарами становятся концевые датчики. Они позволят не выходить за рамки выбранной
области исследования объекта наблюдения. В настоящей статье описано простое решение по эффективному использованию датчиков температуры, влажности, концентрации СО2 и перемещений.
ТЕОРИЯ И ПРАКТИКА СКАНИРУЮЩЕЙ ЗОНДОВОЙ МИКРОСКОПИИ: НОВЫЕ РЕШЕНИЯ ДЛЯ ФИЗИКИ, ХИМИИ, БИОЛОГИИ И МЕДИЦИНЫ
Authors: Ахметова А.И. , Иванов О.В. , Максимова Н.Е. , Советников Т.О. , Терентьев А.Д. , Яминский И.В.
Published: April 2023

С момента первой публикации по сканирующей зондовой микроскопии прошел 41 год. За это время сканирующие зондовые микроскопы, позволяющие заглянуть в наномир, стали практическими инструментами физиков, химиков, биологов, медиков, производственников и учителей. Зондовые микроскопы образовали обширное семейство высокоточных и высокоинформативных приборов для наблюдения топографии, морфологии и широкого спектра физико-химических свойств изучаемых объектов. При этом выдавая детализацию получаемых данных на уровне долей нанометра с временным разрешением в миллисекунды. Остались ли нерешенные задачи? Конечно! Об их небольшой части, о задачах и проблемах в зондовой микроскопии ведется рассказ в этой статье.
El diálogo social y la cultura del encuentro
Authors: Avila Cabezas Fabio Eliseo
Published: April 2023

A theological and pastoral contribution is made about social dialog, inspired in Evangelii Gaudium, to illuminate the social crisis caused by the national strike in Colombia. Rediscovering the dimension of the subject produces dynamism: come out from oneself to meet the other and together, moved by truth, reach agreements. Interpersonal dialog creates a pedagogy of dialog and personal encounter. The principles emerging from the first Apostolic Exhortation of Pope Francis allow proposing a pedagogy of polyhedral social dialog to include all its interlocutors – government, unions, citizens – looking for consensus and promoting the comprehensive development of Colombian peoples. The social dialog and the culture of encounter favor the full development of the human being, seek common wellbeing, and show the path of peace for the country devoted to the Sacred Heart of Jesus.
Algoritmos, sesgos, sexos y géneros: la sensatez del Derecho
Authors: Rivero Ortega Ricardo
Published: April 2023

El propósito de las ciencias sociales y jurídicas es fomentar la convivencia y ayudar a resolver problemas para alcanzar los objetivos de las personas. Cuando surgen conflictos relacionados con el avance tecnológico o las teorías constructivistas, es necesario que los juristas intervengan para encontrar un equilibrio entre el progreso y los intereses afectados por los cambios disruptivos utilizando principios jurídicos.