bluuebunny/crossref_metadata_2025 huggingface dataset:
Deucravacitinib Long-term Efficacy With Continuous Treatment in Plaque Psoriasis: 2-Year Results From the Phase 3 POETYK PSO-1 and PSO-2 Trials
Authors: Thaçi Diamant , Lebwohl Mark , Warren Richard B. , Kircik Leon , Banerjee Subhashis , Napoli Andrew , Kisa Renata M. , Linaberry Misti , Hoyt Kim , Blauvelt Andrew
Published: November 2023

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved in the US, EU, and other countries for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy. Deucravacitinib treatment was superior to placebo and apremilast in the POETYK PSO-1 (NCT03624127) and POETYK PSO-2 (NCT03611751) trials in moderate to severe plaque psoriasis. We evaluated long-term clinical outcomes in patients with ≈2 years (112 weeks) of continuous deucravacitinib exposure.

Methods: PSO-1 and PSO-2 patients were randomized 1:2:1 to oral placebo, deucravacitinib 6 mg once daily, or apremilast 30 mg twice daily. At Week 52, patients were eligible to enroll in the POETYK long-term extension (LTE; NCT04036435) trial and receive deucravacitinib 6 mg once daily. Efficacy outcomes included ≥75%/≥90% reduction from baseline in Psoriasis Area and Severity Index (PASI 75/90) and static Physician Global Assessment score of 0 (clear) or 1 (almost clear) with a ≥2-point improvement from baseline (sPGA 0/1). Efficacy was assessed using modified nonresponder imputation through the data cutoff date of October 1, 2021 (Week 112) in patients receiving continuous deucravacitinib treatment from Day 1 and in patients receiving continuous deucravacitinib treatment who achieved PASI 75 at Week 24. As-observed data and results by treatment failure rules imputation were also analyzed.

Results: A total of 513 patients received continuous deucravacitinib from Day 1 in PSO-1/PSO-2 until Week 112 in the LTE, including 336 patients who had achieved PASI 75 at Week 24. High clinical response rates achieved at Week 52 in PSO-1/PSO-2 (PASI 75, 73.0%; PASI 90, 46.3%; sPGA 0/1, 58.5%) were maintained at Week 112 in the LTE (PASI 75, 76.2%; PASI 90, 48.3%; sPGA 0/1, 58.4%) among patients receiving continuous deucravacitinib treatment from Day 1. High response rates were also maintained in Week 24 PASI 75 responders (Week 52: PASI 75, 90.3%: PASI 90, 62.1%: sPGA 0/1, 73.8%; Week 112: PASI 75, 89.2%; PASI 90, 61.1%; sPGA 0/1, 70.5%). Results were consistent regardless of data imputation methodology.

Conclusion: Deucravacitinib was associated with sustained efficacy through 2 years in patients who received continuous treatment from Day 1 and in patients who achieved PASI 75 at Week 24. High clinical response rates achieved at Week 52 were maintained at Week 112. These findings provide additional support for deucravacitinib as an efficacious long-term treatment for moderate to severe plaque psoriasis.
Performance of the 23-gene Expression Profile (23-GEP) Test by Histopathological Evaluation in an Independent, Multi-Center Performance Cohort of Cutaneous Melanocytic Neoplasms
Authors: Goldberg Matthew S. , Motaparthi Kiran , Hosler Gregory A. , Cockerell Clay J. , Estrada Sarah I. , Depcik-Smith Natalie D. , Plaza Jose A.
Published: November 2023

Histopathologic evaluation can effectively diagnose most melanocytic neoplasms; however, lesions considered to be difficult-to-diagnose pose challenges for accurate classification of malignant potential, which can lead to over- or under-treatment. Ancillary testing to provide additional information is available for such cases. The validated diagnostic 23-GEP test provides an objective result of benign, malignant, or intermediate. In this large, independent cohort, the performance of the 23-GEP in its current laboratory is presented. Lesions from patients ≥18 years old were enrolled from eight centers or from melanoma cases clinically submitted for prognostic 31-GEP testing. Lesions were independently reviewed by 3–5 dermatopathologists and included in the study if they were fully concordant or non-concordant without conflicting diagnoses (i.e., both benign and malignant designations) or majority of unknown malignant potential designations, resulting in a cohort (n=2512) of benign nevi (n=1140) and malignant melanomas (n=1372). Accuracy metrics and two-tailed 95% confidence intervals (CIs) were calculated using resampling x10,000 iterations to establish a balanced number of benign versus malignant samples. The 23-GEP performance within this cohort was 91.3% (95% CI, 89.2–93.2%) sensitivity, 91.9% (89.8–93.8%) specificity, 92.2% (9.30–94.0%) positive predictive value, and 91.0% (89.0–92.9%) negative predictive value; 7.8% of lesions received an intermediate result. These metrics do not deviate significantly from previously published studies. These data demonstrate that the 23-GEP has an overall accuracy of 91.6% (90.1–93.0%), further supporting its use as an ancillary test that can be integrated with clinical and histopathologic information to guide final diagnosis.
Türkiye ve Brezilya'da Talep Rejimlerinin Belirlenmesi: Ücret Çekişli mi Yoksa Kâr Çekişli mi: Post-Kaleckiyen Analiz
Authors: ÜSTÜNDAĞ TUNCA Hatice , IŞIK Sayım
Published: November 2023

Bu çalışmanın amacı, gelir dağılımı eşitsizliğinin sermaye birikimi ve kapasite kullanımı üzerine etkisini Hein ve Tarassow (2010) modelini temel alarak Türkiye ve Brezilya’nın talep rejimini belirlemektedir. Çalışmanın verileri 1988-2019 yılları arasını kapsamaktadır. Bu çalışma her iki ülke için tasarruf oranı, sermaye birikim oranı, net ihracat oranı ve reel döviz kuru denklemlerini ayrı ayrı tahmin etmektedir. Çalışmanın Türkiye ve Brezilya ekonomisi için tahmin sonuçlarından ilki, her iki ülkede de kâr payının kapasite kullanımı üzerindeki etkisinin negatif olduğunu ileri sürmektedir. Buna göre her iki ülke ekonomisi de Kaldor- Verdoorn Yasası’nı desteklemektedir. Çalışmanın ikinci bulgusu, karların sermaye birikimi üzerindeki etkisinin (marjinal esneklik) Türkiye için negatif ve Brezilya için pozitif olduğunu göstermektedir. Türkiye için ücretlerin sermaye birikimi üzerindeki olumlu etkisini Marx-Hicks etkisi ile açıklamak mümkündür. Sonuç olarak bu ampirik bulgular, Türkiye’nin talep rejiminin ücret çekişli olduğu, Brezilya’nın talep rejiminin ise ara talep rejimli olduğunu göstermektedir.
Abstracts of invited presentations at EuroPD congress in Bruges, 2023-11-27
Authors: EuroPD
Published: November 2023

This special issue of the Home Dialysis Bulletin (cross-referenced as Bulletin de la Dialyse à Domicile (BDD)) contains abstracts of guest lectures submitted by the authors.
The abstracts are available in English and French.
The abstracts of the free communications are available at this link.
Many of these abstracts reflect work of particular interest to clinicians and nurses and should be developed into a full article. We, therefore, encourage authors to write a full article and submit it to the BDD at https://www.bdd.rdplf.org if it has not been published or submitted elsewhere. They will be double-blind peer-reviewed and, if accepted, will be published promptly in both languages to ensure the widest possible dissemination.
The BDD supports the Diamond Open Access Action Plan and follows its model (Diamond OA scholarly Communication Ecosystem); it is therefore free of charge for authors and readers and accessible to all health professionals and patients.
 
Ethical considerations: before submitting their abstracts, all authors were informed that their articles would be published in the BDD and translated into French. Authors retain the copyright of their articles.Declaration of interests: Publication of these abstracts is provided free of charge by the French Registry of Peritoneal Dialysis and Home Hemodialysis. No payment or grant has been received from EuroPD or any third party for this work.Copyright: authors retain copyright.
Open data on road traffic accidents accumulation, processing and analysis
Authors: Goryaev N. K. , Lyubetskii S. P.
Published: November 2023

Introduction. An urgent task for any municipality is the development of an Integrated Traffic Management Scheme, which is based on an analysis of the current situation. At the same time, the most important element is the analysis of road traffic accidents (RTA). The purpose of this study is to develop a methodology for accumulating, processing and analyzing the data on road accidents from the main official source - the State Inspectorate for Road Safety (GIBDD).

Description of the problem. The data can be uploaded from the traffic police portal in two formats, but none of them allows for automated analysis of road accidents and presentation of its results using geographic information systems (GIS).

Proposed methodology. The paper proposes a methodology for analyzing traffic accidents, including the following steps: uploading data from the site, converting data into convenient formats, entering data into a geographic information system, analyzing data using geographic information systems.

Methodology approbation. Using the proposed methodology, an analysis of traffic accidents in the Cheboksary agglomeration was made and its visualization was made using GIS.

Conclusions. The use of information about road accidents in the formats offered on the traffic police website is impossible either for analysis or for visualization in a GIS. The proposed method for accumulating, processing and analyzing accidents based on data from an official source using GIS makes it possible to automate the process and improve the quality of accident analysis.
On possible petrol ignition on М1, М1G car catalyst converters surface
Authors: Nedobitkov A. I. , Yakovlev V. S.
Published: November 2023

Introduction. Forensic fire and technical examination of a car is of high demand, and at the same time it is one of the most complicated examinations, because of its complicated nature and need in involvement of experts of various specialties. The design of automobiles and their components is continually improving. In this connection the methodological base of fire and technical examination should be duly adapted to present-day requirement. The safety requirements for prevention of fuel ignitions in a motor cabinet of a car have been analyzed during the research.

Materials and Methods. Under the conditions of an accredited laboratory specializing in testing automobile fuels and oils, we have carried out the experiments in ignition of K4-class petrol being fed in drops and stream-like fed on a hot surface. We have also undertaken the experimental studies in order to find out an actual temperature of elements of engine exhaust systems of М1 and М1G automobiles of various models under the actual operating conditions. A thermal imaging camera and a thermocouple have been used to measure the surface temperature of the engine exhaust system parts. An elemental composition of a film formed on a hot steel surface upon contact with petrol has been determined with the use of a scanning electron microscope

Results. We have received the actual results on the temperature of the elements of light car exhaust systems under the various operating conditions. There are the results of experiments on the discharge of the petrol in the form of drops and stream on a hot surface presented in the article. An elemental composition of a film formed on a hot steel surface upon contact with petrol has been analyzed, and secondariness of film formation towards the fire cause has been proved.

Conclusion. The results of the research could be used in the conduct of fire and technical examination of vehicles of М1 and М1G categories, what could increase reliability and validity of its conclusions.
NONFICTIONAL LITERATURE: NATURE, TYPOLOGY, TERMINOLOGY
Authors: CHERKASHYNA Tetiana , PARAMONOV Bohdan
Published: November 2023

The article is devoted to the reviewing of theoretical aspects of nonfiction literature. Similar in semantic content, but not identical terms as nonfictional literature, nonfictional writing, literature of fact, factography, fiction-documentary literature, fiction-documentary prose, fiction-documentary writing, literary nonfiction, literature of non-fiction, nonfictional prose, factual narrative, which have become commonly used in American, Spanish, Ukrainian, French, Slavic terminology, are analyzed. All these terms refer to a set of texts written on the basis of real events without the use of fiction. Typical features of this type of literature are the synthesis of documentary components and fiction, veracity, factuality, authenticity, objectivity, the use of real names, dates and geographical indications. At the same time, the reflection of real events and their participants is presented through the prism of the author’s self, and therefore subjectivity, personal component, merging of images of the author and the narrator are added to the leading features of nonfiction literature.

The article focuses on the main structural and typological branches of nonfiction literature – historical nonfiction, literary biography, fictional journalism and memoirs. In compiling this classification, the main object of the non-fiction narrative was taken into account in the first place; sources of documentary information; varieties of author's presence in the text (in particular, as an outside observer, witness or main character); subjective factor of personal participation in the events described in the work, or personal acquaintance with the direct participants in the events; genre-typological characteristics of nonfictional works. The article highlights the main typological characteristics of each type of non-fiction, analyzes their genre system, presents the characteristics of varieties and subvarieties.

Particular attention is paid to the analysis of memoirs, which is a complex and multilevel type of non-fiction, which, in turn, consists of several subvarieties – the memoirs, the autobiography, the diary, the epistolary. The article differentiates the subvarieties of memoir literature, considers options for the synthesis of its types and forms.
Analysis of The Effect of Tax Socialization, Tax Sanction, and Quality of Service of Tax Officials on MSME Taxpayer Compliance (Case Study on Individual and Entity Taxpayers in Pati Regency)
Authors: Janan Samahul , Mokhlas Mokhlas
Published: November 2023

 

This study aims to determine the effect of Tax Socialization, Tax Sanctions, and Service Quality of Tax Officers on MSME Taxpayer Compliance.The population in this study are individual taxpayers and MSME entities registered at the KPP Pratama Pati Regency. Samples were taken as many as 100 respondents using the incidental sampling method, namely a sampling technique where the distribution of questionnaires in this case was carried out to respondents who were willing or willing to be asked for data by researchers. While collecting data using a questionnaire.  The results of this study indicate that Tax Socialization has a significant positive effect on Taxpayer Compliance, Tax Sanctions have a significant positive effect on Taxpayer Compliance, and Service Quality of Tax Officers has a significant positive effect on Taxpayer Compliance, and Tax Dissemination, Tax Sanctions and Service Quality of Tax Officers simultaneously significant positive effect on Taxpayer Compliance.

 

 
The Effect of Financial Ratio Performance on Credit Distribution (Study on Commercial Banks in Indonesia for the 2020-2022 Period)
Authors: Charakas Nana Yohana , Putri Ika Swasti
Published: November 2023

The goal to be realized in this study is to provide partial or simultaneous empirical evidence of the effect of CAR, NPL, LDR, ROA, DPK on lending.  In this research using secondary data. The sample in this research amounted to 60 data using a purposive sampling technique. In analyzing the data using multiple linear regression analysis test, t test, F test and the coefficient of determination.  Relying on the results obtained in partial and simultaneous research CAR, NPL, ROA have a non-significant positive effect on lending, LDR, DPK have a significant positive influence on lending. The results of the calculation of the coefficient of determination are 99.2% while the remaining 0.8%.

Keywords : Lending, CAR, NPL, LDR, ROA, DPK.
Characterisation and phytochemical profile of sunlight exposed freeze-dried
oyster mushroom (Pleurotus ostreatus) powder
Authors: Nongmaithem B.D. , Chinnappan A.K.
Published: November 2023

Mushrooms are vitamin B and D rich fungi which belong to the division Basidiomycota.
Oyster mushroom (Pleurotus ostreatus) has distinct flavour, contains high nutrients and
phytochemicals. Phytochemicals are naturally existing compounds which play with
nutrients to protect against diseases. The aim of the study is to characterise and compare
the phytochemical profile of sunlight exposed freeze-dried oyster mushroom (SEFDOM)
powder and non-sunlight exposed freeze-dried oyster mushroom (NSEFDOM) powder.
The phytochemical constituents of both SEFDOM and NSEFDOM powder were extracted
using aqueous, methanol and ethanol. Eighteen metabolites were screened for all the three
solvents for both the samples. The phytochemical screening showed that the presence of
alkaloids, flavonoids, sterols, proteins, carbohydrates, saponins for both samples were
detected while other remaining metabolites were not detected. The results showed that the
metabolites such as alkaloids, sterols, anthraquinones and carbohydrates were appreciable
in the NSEFDOM powder group when compared to SEFDOM powder samples. Protein
content was found to be high in SEFDOM powder group with ethanol extraction. The
overall phytochemical extraction efficiency is high in methanol solvent. This study found
that the amount of phytochemical content in non-sunlight exposed freeze-dried oyster
mushroom powder was higher than sunlight exposed oyster mushroom powder.
Edukasi Kesehatan dan Olahraga Sebagai Pencegahan Obesitas dan Perilaku Sedentari Pada Siswa
Authors: Agafian Dhuha Ahad , Yogaswara Andre , Seh Abu Bakar Sayid Fariz bin , Widodo Agung , Muhibbi Muhammad , Mif Mifbakhuddin , Prasetio Diki Bima , S Sayono , Sumanto Didik
Published: November 2023

Latar belakang: Obesitas sudah menjadi epidemi global penyakit tidak menular yang mengancam seluruh penduduk dunia. Obesitas merupakan kondisi yang diakibatkan oleh tidak seimbangnya intake makanan yang masuk dengan energi yang dikeluarkan sehingga menyebabkan tumpukan lemak di dalam tubuh. Tujuan: untuk melakukan edukasi remaja terkait kebugaran dan kesehatan agar tidak terjebak dalam perangkap kemajuan teknologi yang membawa pada perilaku sedentary. Metode:  Pengabdian dilaksanakan dalam bentuk edukasi melalui ceramah dan praktik latihan langsung di kelas. Pengetahuan responden diambil dengan kuesioner sebelum dan setelah kegiatan berlangsung. Hasil: siswa hanya melakukan aktivitas fisik 1 kali dalam seminggu yaitu saat jam pelajaran penjaskes di sekolah. Rerata denyut nadi siswa berkisar antara 90-100 kali per menit. Pada latihan kebugaran push up, kategori kurang sebanyak 28 siswa, kategori cukup 7 siswa, dan kategori baik 3 siswa.  Tes kebugaran sit up, kategori kurang sebanyak 26 siswa, kategori cukup 6 siswa, kategori baik 6 siswa. Kesimpulan: Sebagian besar tingkat kebugaran jasmani siswa SMA MIBS Kebumen dalam kategori kurang. Edukasi meningkatkan pengetahuan siswa tentang kesehatan dan kebugaran.
Kata kunci: obesitas, sedentari, kebugaran
_______________________________________________________________________________________
Abstract
Background: Obesity has become a global epidemic of non-communicable diseases threatening the entire world's population. Obesity is caused by an imbalance between incoming food intake and expended energy, causing fat deposits in the body. Objective: educate youth about fitness and health so they don't get caught in the trap of technological advances that lead to sedentary behavior. Method: Community service is done through education through lectures and hands-on practice in class. Respondents' knowledge was taken with a questionnaire before and after the activity. Result: students only do physical activity once a week at school, namely during physical education lessons. The average student's pulse ranges from 90-100 beats per minute. In the push-up fitness exercise, there were 28 students in the less category, seven students in the sufficient, and three in the good. Sit-up fitness test, 26 students were lacking, six were adequate, and six students were good. Conclusion: Most of the physical fitness levels of SMA MIBS Kebumen students are in the poor category. Education increases students' knowledge about health and wellness.
Keywords: obesity, sedentary, fitness
Penyuluhan Hipertensi dan Pemeriksaan Tekanan Darah Pada Remaja
Authors: Fitrianah Fia , Sucipto Mega Rahmawati , Sekardi Fadiya Nursuci , Wulandari Cahya , Masfuah Lulu Zalianti , Aiyanti Silvia Nur , Mifbakhuddin
Published: November 2023

Latar belakang: Hipertensi merupakan kejadian peningkatan tekanan darah sistolik lebih dari 140 mmHg dan diastolik lebih dari 90 mmHg yang melebih batas normal. Faktor risiko utama yang berpengaruh menyebabkan hipertensi yaitu umur, jenis kelamin, suku, faktor genetik, faktor lingkungan seperti obesitas, stress, konsumsi garam, merokok, dan konsumsi alkohol. Tujuan: untuk meningkatkan pengetahuan tentang hipertensikelompok usia produktif. Metode: Metode yang dilakukan dalam kegiatan intervensi ini yaitu dengan metode ceramah dan pemberian media cetak berupa poster. Kegiatan penyuluhan diawali dengan pre-test menggunakan software Quizziz dan dievaluasi menggunakan post-test. Kegiatan penyuluhan diakhiri dengan pemeriksaan tekanan darah. Hasil: Hasil pre-test pengetahuan peserta mengenai hipertensi yang termasuk dalam kategori kurang sebesar 19,2%, pengetahuan cukup sebesar 38,5%, dan pengetahuan baik mengenai hipertensi sebesar 42,3%. Setelah diberikan penyuluhan hipertensi dilakukan post-test yang menunjukkan bahwa peserta memiliki pengetahuan cukup mengenai hipertensi sebesar 34,6% dan mempunyai pengetahuan baik mengenai hipertensi sebesar 65,4%. Berdasarkan hasil pre-test dan post-test diketahui terjadi peningkatan pengetahuan setelah dilakukan penyuluhan. Kesimpulan: Penyuluhan kesehatan yang dilakukan dapat meningkatkan pengetahuan peserta terkait hipertensi.
Kata kunci: hipertensi, penyuluhan, tekanan darah
________________________________________________________________________________
Abstract
Background: Hypertension is an increase in systolic blood pressure more 140 mmHg and diastolic more 90 mmHg which exceeds normal limits. The main risk factors that influence hypertension are age, sex, ethnicity, genetic factors, and environmental factors such as obesity, stress, salt consumption, smoking, and alcohol consumption. Objective: to increase knowledge about hypertension in the productive age group. Method: The method carried out in this intervention activity is by lecture method and giving print media in the form of posters. Counseling activities begin with a pre-test using quizziz software and are evaluated using a post-test. The counseling activity ended with a blood pressure check. Result: Pre-test results of participants' knowledge about hypertension which is included in the category of less than 19.2%, sufficient knowledge of 38.5%, and good knowledge about hypertension of 42.3%. After being given hypertension counseling, a post-test was carried out which showed that participants had sufficient knowledge about hypertension by 34.6% and had good knowledge about hypertension by 65.4%. Based on the results of the pre-test and post-test, it is known that there is an increase in knowledge after counseling. Conclusion: Health counseling conducted can increase participants' knowledge related to hypertension.
Keywords: blood pressure, counseling, hypertension
Edukasi Pencegahan Anemia Pada Ibu Hamil
Authors: Wulandari Anggrawati , Siwi Retno Palupi Yonni , Retnaningtyas Erma , Mukarromah Azizatul , Lende Frendina Kurnia
Published: November 2023

Latar belakang: Anemia pada kehamilan merupakan masalah karena mencerminkan nilai kesejahteraan sosial ekonomi masyarakat dan berpengaruh sangat besar terhadap kualitas sumber daya manusia. Anemia pada ibu hamil disebut ”potencial danger for mother of child” (potensial membahayakan bagi ibu dan anak) karena itulah anemia memerlukan perhatian serius dari pihak yang terkait dalam pelayanan kesehatan pada lini terdepan. Tujuan: pengabdian masyarakat ini adalah untuk Meningkatkan pengetahuan ibu hamil tentang pencegahan Anemia kehamilan. Metode: Kegiatan ini dilakukan dengan memberikan penyuluhan dengan leaflet kepada ibu hamil tentang pencegahan anemia kehamilan dengan memberikan pre tes sebelum penyuluhan dan post tes sesudah penyuluhan. Hasil: Hasil penyuluhan didapatkan sebelum diberikan penyuluhan sebanyak 3 peserta (30%) dengan pengetahuan Baik dan setelah kegiatan terdapat peningkatan menjadi 8 peserta (80%) dengan pengetahuan Baik. Kesimpulan: Edukasi kesehatan dapat meningkatkan pengetahuan yang berhubungan dengan kejadian anemia.
Kata kunci: anemia, edukasi, ibu hamil
______________________________________________________________________________
Abstract
Background: Anemia in pregnancy is a problem because it reflects the value of the socio-economic welfare of the community and has a very large influence on the quality of human resources. Anemia in pregnant women is called "potential danger for mother of child" (potentially dangerous for mother and child) because of that anemia requires serious attention from those involved in health services at the forefront. Objective: this community service is to increase pregnant women's knowledge about preventing anemia in pregnancy. Method: This activity is carried out by providing counseling with leaflets to pregnant women about preventing anemia in pregnancy by giving pre-test before counseling and post-testing after counseling. Result: The results of counseling were obtained before counseling was given as many as 3 participants (30%) with good knowledge and after the activity there was an increase to 6 participants (60%) with good knowledge. Conclusion: Health counseling conducted can increase participants' knowledge related to anemia.
Keywords: anemia, education, pregnant woman
Pemanfaatan Apotek Hidup Sebagai Kearifan Lokal di Gampong Alue Deah Teungoh Kota Banda Aceh
Authors: Santi Tahara Dilla , Arifin Vera Nazhira , Candra Aditya , Arbi Anwar , Khaira Uswatul , Sanju Bunga Salsa
Published: November 2023

Latar belakang: Kesehatan keluarga dan masyarakat merupakan salah satu aspek penting yang perlu diperhatikan. Dalam rangka mencapai tujuan tersebut maka tanaman obat keluarga merupakan alternatif pilihan pertama dalam pengobatan. Tujuan: Mensosialisasikan pemanfaatan apotek hidup sebagai kearifan lokal. Metode: Metode presentasi untuk sosialisasi tentang pengertian apotek hidup, jenis tanaman obat, manfaat apotek hidup, cara mengolah tanaman obat, serrta dilanjutkan dengan tanya jawab dengan para peserta yang hadir dan metode pembagian booklet kepada peserta. Hasil: Peserta sangat antusias untuk mengikuti kegiatan yang ditunjukkan dengan fokusnya perhatian mereka pada materi yang diberikan oleh tim PkM. Mayoritas peserta mendapat pengetahuan tentang apotek hidup dan pemanfaatannya. Kesimpulan: Hasil kegiatan ini dapat membangun kesadaran dan pemahaman peserta dalam mengidentifikasi apotek hidup yang dapat dimanfaatkan oleh keluarga tujuan mendapatkan pengobatan pertama terhadap masalah kesehatan.
Kata kunci: apotek hidup, kesehatan keluarga, tanaman obat
___________________________________________________________________________________________
Abstract
Background: Family and community health is an important aspect that needs attention. In order to achieve this goal, family medicinal plants are the first choice alternative in treatment. Objective: To socialize the use of living pharmacy as local wisdom. Method: Presentation method for socializing the meaning of living pharmacy, types of medicinal plants, the benefits of living pharmacy, how to process medicinal plants, followed by a question and answer session with the participants who were present and the method of distributing booklets to participants. Result: Participants were very enthusiastic about participating in the activity which was shown by their focused attention on the material provided by the PkM team. As a result of socialization and education from the community service team, the majority of participants already have good knowledge about living pharmacies and their use. Conclusion: The results of this activity have been able to build awareness and understanding of participants in identifying living pharmacies that can be used by families as the smallest line and the community in general with the aim of getting the first treatment for health problems.
Keywords: living pharmacy, family health, medicinal plants
Unlocking Classroom Potential: Exploring the Mediating Role of Teacher Mindset on Embracing Differentiated Instruction
Authors: Hasanah Enung , Al Ghazy M. Ikhsan , Suyatno Suyatno , Maryani Ika , Mohd Yusoff Mohd Zailani
Published: November 2023

Differentiated Digital Instruction (DDI) is a viable solution to cater to students' personalised learning needs in 21st-century education. Despite the numerous benefits associated with this model, not every teacher has the capability or willingness to adopt it, primarily because of its perceived complexity. This research examines the direct and indirect relationship between teacher knowledge about digital differentiated learning and the availability of digital infrastructure in schools on implementing digital differentiated learning through the mediating role of teacher mindset through structural equation modelling. This study was conducted among junior high school teachers in West Sumatra, Indonesia. A simple random sampling technique was used for data collection. The collection and sample size consisted of 161 participants. The data analysis process was carried out using SmartPLS 4 Structural Equation Modelling (SEM) analysis. These findings contribute to the idea that the teacher's mindset is a mediator between digital differentiated learning and the availability of digital infrastructure for implementing digital differentiated learning. This research is helpful for school principals to prioritise developing teacher mindsets first before instructing the implementation of digital differentiated learning in schools. As this study highlighted the importance of this subject, it also emphasised the need for further exploration of additional factors regarding the implementation of the digital differentiated instruction model.
Maria
Authors: Romero Galo
Published: November 2023

Born and raised in Queens, New York, Galo Romero is a first generation American of Ecuadorian descent. His creative writing mixes the fantastic, bizarre, macabre, and mundane, with reflections of his Ecuadorian-American upbringing.
Correlation of serum and follicular fluid EMMPRIN levels at day of ova pick up and embryo transfer to endometrial thickness and its effect on ICSI outcomes in fresh cycles
Authors:   High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Almousa Methaq , Abdulwahid Mohammed Amal ,   The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Ibrahim Rahim Ali ,   Faculty of Medicine, University of Kufa, Najaf, Iraq
Published: November 2023

EMMPRIN (Basigin) is a potent inducer of matrix metalloproteinases (MMPs). Expression of EMMPRIN in the uterus has a very important role in implantation of embryo, this study was conducted to evaluate the relationship of pregnancy rates with EMMPRIN levels in follicular fluid and serum of intracytoplasmic sperm injection patients. The study was cross sectional study analyzed the serum and follicular fluid samples of 58 patients undergo ICSI procedure. The serum and follicular fluid samples were collected from infertile women aged 20 to 42 years. However, the levels of EMMPRIN were measured in the serum and follicular fluid samples and these samples were obtained during oocytes retrieval and another serum samples were collected at the day of embryo transfer. All women have ovarian stimulation with recombinant follicle stimulating hormone (FSH) at the second or third day of the cycle. Result: The pregnancy rate was 27.6 %. The present study showed that EMMPRIN in serum and follicular fluid at day of ova pickup and its level at embryo transfer day, are significantly low in pregnant women (p < 0.05) compared to non-pregnant women. The statistical analysis showed no significant correlation between serum and follicular fluid EMMPRIN with endometrial thickness (p > 0.05). EMMPRIN level can be used as a promising parameter for the prediction of pregnancy rate in ICSI cycles
Evaluation of LH Level at Different Time Points During the Follicular phase in ICSI Cycle and Correlation with Pregnancy
Authors:   The High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, muhssin Sahar , A. AL-Anbari Lubna ,   High Institute for Infertility Diagnosis and Assisted Reproductive Technologies/Al-Nahrain University
Published: November 2023

Luteinizing hormone (LH) plays vital role for optimal follicular growth, maturation and is responsible for inducing ovulation, various protocols in ICSI cycles used to prevent the premature surge of luteinizing hormone. Currently, flexible GnRH antagonist protocols appears to be mostly used protocols. individualization of controlled ovarian hyper stimulation (COS) needs better timing of antagonist administration, assessing variation in LH levels during COS helps in determining appropriate initiation of inhibition .This prospective comparative observational analysis was made on one hundred twenty females with infertility who were undergoing ICSI flexible antagonist protocol at the “High Institute for Infertility Diagnosis and Assisted Reproductive Technologies/Al-Nahrain University” from October 2020 to April 2022, primary infertility was the with higher percentage (78.3%) than the secondary type. However; the main cause of infertility among the participant was male type (36.7%) fallowed by the combined one (20.8%). A highly significant difference was present in LH levels at all time points, with level decreasing from 4.99 ± 1.90 at baseline to 4.82± 2.15 at antagonist starting day to 1.63± 0.87 at trigger day and p value was > 0.001, no statistical difference in LH levels regarding the three time points between patients who get pregnant and non-pregnant women with pregnant patients having higher baseline lower antagonist starting day, and higher trigger LH levels 5.16 ± 1.87, 4.30 ± 1.72, 4.30 ± 1.72 respectively. Difference in LH level between cycle day 2 and the day of antagonist starting according to starting day of antagonist reveals that the basal LH values declined significantly (p= <0.001) until cycle day 7 of stimulation after which the basal LH start to increase and also with a high significant difference (negative values mean that the level decrease in comparison to the base line level).The comparable LH level in the current study reveals that earlier initiation of antagonist may serve no purpose and it is advisable to include the measurement of LH level to the criteria of antagonist initiation for better individualization and better outcome and to avoid un necessary earlier start of antagonist
Efficient removal of lead(II) ions in water using functionalized poly(styrene) oligomers
Authors: Sánchez Anguiano Maria G. , Oliva de Dios Mauricio L. , Chan Navarro Rodrigo , Elizondo Martínez Perla , Rosa M.  , García López María Concepción
Published: November 2023

In this research, chemically functionalized polystyrene oligomers with acrylamide monomers were applied as alternative adsorbent towards Pb(II) from aqueous solutions. Adsorption process of Pb(II) was optimized using the 2*' fractional factorial design with replicates at the central point supplemented with the central composite design where the percentage adsorption was chosen as the response variable. This variable was simultancously optimized using the desirability functions approach to select the best conditions for the adsorption process. The experimental data reveal that after the optimization, the maximal response was exhibited at 38 °C, pH 5.80, initial adsorbate concentration (36.40 mg L™, and adsorbent dosage  (10.77 mg) with the desirability function of 0.9260. Theoretical values and experimental data determined by the central composite design showed a high correlation with a R? value of 0.9810. Under these optimal conditions, the theoretical value for the removal of Pb(II) was 93.12%, while that experimental assay gives a maximum value of 91.23%. Likewise, the analysis of surface charge distribution, the structural and morphological characteristics confirmed the successful chemical modification of poly(styrene) oligomers.
The influence of remote work on ergonomics and work satisfaction
Authors:   Bydgoszcz University of Science and Technology, Drewniak Zbigniew , Goździewska-Nowicka Agnieszka ,   Bydgoszcz University of Science and Technology, Słupska Urszula ,   Bydgoszcz University of Science and Technology
Published: November 2023

Purpose: The purpose of the article is to present the impact of remote work on ergonomics and job satisfaction. The purpose of the study is understood from the perspective of the impact of remote work on corporate employees. Design/methodology/approach: Data for the study was collected from employees working at a corporation in Bydgoszcz, Poland. The study used the PLS (partial least squares) analysis method to understand the relationship between remote work and job satisfaction, and between work ergonomics and remote task performance. Findings: The results of the study indicate that ergonomics closely influences job satisfaction. In addition, the study confirmed the hypothesis that remote work has a significant impact on task performance. Research limitations/implications: The study is limited to employees of corporations in a specific region of Poland. Therefore, future research could focus more on the impact of remote work on corporate culture in other parts of Poland. Practical implications: The study provides directions for human resource management to implement effective practices for improving remote work. Social implications: This study offers support for corporate employees, providing insights into how the work environment can be improved, thereby enhancing work and employee satisfaction. Originality/value: This is a study that attempts to provide insight into how ergonomics is important in corporate work, especially when working remotely. The findings provide important implications for improving ergonomics at work and increasing employee satisfaction. Keywords: management, human resources, remote work, ergonomics, job satisfaction. Category of the paper: research paper.
Sustainable consumption among children in the aspect of waste management
Authors:   University of Zielona Góra, Kulyk Piotr , Kaźmierczak-Piwko Leszek ,   University of Zielona Góra, Dybikowska Adrianna ,   University of Zielona Góra, Dubicki Piotr ,   University of Zielona Góra
Published: November 2023

Purpose: The aim of the study was to identify consumption patterns among children. The article analyses the concept of sustainable consumption, focusing on children’s consumption behaviour patterns in the field of sustainable waste management. Design/methodology/approach: The paper uses a critical analysis of the literature and survey research based on a prepared questionnaire. The survey was conducted among 1326 children in age groups from 9 to 15 years old. The questionnaire consisted of two parts, i.e. the substantive part and the respondents’ particulars. The first part of the questionnaire contained a set of questions concerning e.g. children’s ability to identify products with better environmental parameters, behaviours related to nutrition, saving, shopping, spending free time, waste management and implementing pro-ecological solutions in their households. Findings: The survey conducted among young consumers primarily pointed to the shortcomings of knowledge on waste segregation. Despite the fact that the vast majority declare that waste is collected selectively in their homes, they are unable to correctly indicate what type of waste should be thrown into the appropriate bins. Therefore, it is recommended that in each school, both primary and secondary, there are containers for selective waste collection, along with a description and instructions on what kind of waste should be placed in them. Undoubtedly, this will increase the ecological awareness of children and teach pro-ecological behaviour. Practical implications: Modification of primary school curricula to a greater extent emphasizing content related to the principles of sustainable consumption in the area of rational waste management. Social implications: Shaping sustainable consumption patterns among children by building awareness of appropriate behavior in the field of post-consumer waste management. Originality/value: The article presents the current state of knowledge on consumption patterns among children in the area of waste management. This is a particularly important issue in the context of shaping sustainable consumption patterns among the surveyed group of market participants. Keywords: sustainable consumption, food products, a child as a consumer, food market, ecolabelling. Category of the paper: Research paper.
The situation in the fight against the pandemic in Ukraine just before the war was improving
Authors:   Department of Information And Communication Technologies And Systems, National Technical University of Ukraine «Igor Sikorsky KPI» Kyiv, Ukraine, Skulysh Mariia , Wilinski Antoni ,   Department of Computer Science, WSB Merito University in Gdansk, Poland, Kozłowski Artur ,   Department of Law and Administration, WSB Merito University in Gdansk, Poland
Published: November 2023

Purpose: The aim of the article is to compare the efficiency of pandemic management in two conflicting countries - Russia and Ukraine. The thesis about the superiority of Russia over Ukraine in terms of many social and economic factors seemed obvious. Reality measured with logically defined data contradicts this thesis. The use of statistical data ended on the day the war began. Design/methodology/approach: Each of the two considered countries was treated as an administrative structure divided into regions (oblasts). It was assumed that the quality of regional management by the central authority should be assessed on the basis of fair and equal treatment of all regions. This assessment was made for two statistical factors - the number of deaths and the number of vaccinations, whose distribution in the country was assessed according to the Gini index. Findings: Just before the war broke out – in February 2021, indicators of efficient pandemic management in the regions were better for Ukraine than for Russia. Ukraine recovered from the pandemic faster. This is a rather unexpected result. The article justifies the historical background of the centuries-old social and political relations between Russia and Ukraine, also using the position of Poland in these relations. Research limitations/implications: The presented research, together with its methodology, can be repeated for any administrative structure (state, group of countries), regions, cities, etc. An obvious requirement for conducting such research is the availability of reliable data on deaths and vaccinations. Practical implications: The method can be used to assess the efficiency of pandemic management at any administrative level (states, regions, groups of cities, etc.). Originality/value: An important novelty and the result of the research is the discovery of the Ukrainian organizational advantage in the fight against the pandemic just before the outbreak of the war. Keywords: Ukraine's war with Russia, COVID-19, vaccinations, pandemic deaths, pandemic management. Category of the paper: Research paper.
The impact of logistics and marketing customer service on e-commerce
Authors:   University of Lodz, Tokarski Daniel , Wolak Dorota ,   University of Lodz
Published: November 2023

Purpose: The aim of the study is to retain young customers shopping online. The subject of the study concerns the area related to management and optimization of management during online logistics and marketing purchases. Design/methodology/approach: E-commerce has been steadily gaining more and more supporters in recent years. The Covid-19 pandemic and the restrictions introduced in stationary trade were of particular importance for online shopping. The role of logistic customer service and the impact of online advertising on purchasing decisions were examined. Survey research is the most popular method of social research, therefore, in order to obtain data necessary to achieve the goal of the work, a research tool was used, which is a survey questionnaire. Findings: A detailed analysis concerned the impact of online advertising on the purchasing decisions of young consumers. It is an inseparable element of using network resources and allows you to reach a very wide audience - Internet users. It is this type of advertising that has the greatest impact on consumers, which is related to the constantly growing number of people using the Internet. Originality/value: The publication covers the subject of impact of logistics and marketing customer service on e-commerce. Combining interdisciplinary research in the areas of management and quality science with economics and finance. Keywords: e-commerce, logistic customer service, internet marketing. Category of the paper: research paper.
Implementing full-time remote work in the IT sector: consequences and solutions
Authors:   University of Gdańsk, Wróbel Piotr
Published: November 2023

Purpose: The COVID-19 pandemic allowed companies to test the full-time remote work performed by the majority of employees. So far, such a workplace model has been rarely used in companies. Partial remote or full-time remote work dominated but carried out by a relatively small proportion of employees. The aim of the study was to identify the key consequences that appeared in IT companies during the implementation of full-time remote work and actions that were or may be taken in response to them. Design/methodology/approach: Comparative case studies method – seven companies representing different segments of IT sector. Case studies were prepared with the use of interviews and documents analysis. Findings: The assessment of the effects of full-time remote work has changed over time, from surprisingly positive in the first period to a more nuanced and complex one, including both positive and negative side effects. Over time, the approach of study participants to remote work began to change. Most of them began to gradually reduce its scale, encouraging or obliging employees to partially return to their offices. Research limitations/implications: The subject of research is extremely dynamic due to social and technological changes. For example, the development of communication tools may have a significant impact on some of the identified effects of remote work. Practical implications: The contribution of the study is indication of critical areas that require addressing by companies when implementing this form of work. The pandemic will bring a permanent change in the workplace organization, and the effective implementation of new hybrid models requires deep understanding of the full-time remote work consequences. This study supports the creation of such models and the selection of tools that will allow to use full potential of remote work. Originality/value: The novelty of the research is recognizing the dynamics of the full-time remote work effects. Although the study was conducted among IT companies, its results may also be useful in other sectors. Keywords: remote work, distant work, telework, work from home, COVID-19. Category of the paper: research paper.