bluuebunny/crossref_metadata_2025 huggingface dataset:
PERAN LABORATORIUM DALAM DIAGNOSIS DAN PENATALAKSANAAN KASUS KASUS PENYAKIT TROPIK DAN INFEKSI
Authors: Sardjono Teguh Wahju , Ismanoe Gatoet , Widjayanto Edi
Published: January 2017

Infectious disease is still a health problem in theworld, especially in tropical and developing countries, including Indonesia. TheÂ diagnosis of tropical disease cases mostly are still based on the main of clinical symptoms, that is fever. Among 900 fever patients,Â 21% of the disease were diagnosed by clinical examinations, 35% by laboratory tests and 40% were diagnosed as fever of unknownÂ origin (FUO). One forth of the FUO patients were definitively diagnosed after specific laboratory tests, but the use of the specific testsÂ in daily practice were relatively rare. The tests ordered by physicians to the Department of Central Clinical Laboratory Dr. Saiful AnwarÂ Hospital Malang, are mostly hematology and blood chemical tests (59.54% and 21.52%). Specific tests for microbiology andÂ parasitology were only 3.15% and 0.46% respectively. Fever patients who not definitively diagnosed, often received unnecessaryÂ treatments or medications (over-treatment), those are actually dangerous to them. To improve the quality of clinical management, theÂ traditional laboratory service should be changed tobe the interactive laboratory service. It needs a Â role, understanding and goodÂ collaboration between clinical practitioners who know the basic sciences and the pre/para-clinical scientists who interest to the clinicalÂ phenomenon. The aim of the change is to get the more scientific, ethical and professional medical services.Â Key words:Laboratory medicine, diagnosis,management, infectious disease
HUBUNGAN PENINGKATAN TEKANAN INTRAVESIKA URINARIA DENGAN PERDARAHAN INTRAPERITONEAL AKIBAT TRAUMA TUMPUL ABDOMEN
Authors: Soemarko M.
Published: January 2017

The diagnosis of intraperitoneal hemorrhage must bequickly with a high accuracy, before an acute exploratory laparotomy. This studyÂ was conducted to find out if intravesical pressure measurement should be as an alternative indicator of diagnostic peritoneal lavage inÂ predicting intraperitoneal hemorrhage that indicating an acute exploratory laparotomy. Using an Explorative, Cross Sectional Design.Â Results of the exploratory laparotomy were used as Â a standard of determining the accuracy of Diagnostic Peritoneal Lavage andÂ intravesical pressure measurement in predicting theindication for the exploratory laparotomy. 18 of 24 patients has positive results ofÂ diagnostic peritoneal lavage, but an active intraperitoneal hemorrhage only found in 15 patients, witha positive predictive value 83,33Â %, negative predictive value 100%. The results of intravesical pressure measurement in the same patients predicted 17 patients hasÂ positive results, with slight a higher positive predictive value (88,24 %), negative predictive value Â 100%. The conclusion is theÂ measurement of intravesical pressure is an alternative procedure of Diagnostic Peritonel lavage for predicting intraperitonealÂ hemorrhage.Â Key words:Blunt Trauma Abdomen; Intravesical Pressure Measurement; Diagnostic Peritoneal Lavage; Exploratory Laparotomy; IntraperitonealÂ Hemorrhage.
UJI EFEKTIFITAS DEKOK BUNGA BELIMBING WULUH (Averrhoa bilimbi) SEBAGAI ANTIMIKROBA TERHADAP BAKTERI Salmonella Typhi SECARA IN VITRO
Authors: Ardananurdin Alhamfaib , Winarsih Sri , Widayat Mahono
Published: January 2017

Salmonella typhi is causative agent of typhoid fever and its still a main health problem in Indonesia.Pickle fruit flower had beenÂ recognized by Indonesian society that have usefulness to cure various diseases. Pickle fruit flower contain active substance ofÂ saponin, polifenol and flavonoids. The experimentallaboratoric aim was to know the efficacy of picklefruit flower decoct as anÂ antimicrobial agent to Salmonella typhi in vitro byusing tube dilution method and continued by streaking on Bismuth Sulfite Agar. TheÂ concentration of pickle fruit flower decoct were 0%; 5%; 7.5%; 10%; 12.5%; and 15% and the sample of Salmonella typhi were 4Â isolates derived from different patients. The concentration of Salmonella typhi was 104cell/ml. The result from the experiment wasÂ MIC at 10% and MBC at 12,5% concentration. The statistic analysis showed that pickle fruit flower decoct can reduce SalmonellaÂ typhi growth in vitro significantly (Anova, p=0.000) and there was a correlation between increasing concentration of pickle fruit flowerÂ with the reduced amount of colonies (correlation, R=-0.795). From this study we can conclude that pickle fruit flower decoct has anÂ antimicrobial effect to Salmonella typhi fondly of MIC and MBC at 10% and 12.5% respectively.Â Key word:The pickle fruit flower, Salmonella typhi, MinimalInhibition Concentration (MIC), Minimal Bactericidal Concentration (MBC).
EFEK EKSTRAK DAUN CIPLUKAN (Physalis minima L) TERHADAP RELAKSASI OTOT POLOS TERPISAH TRAKEA MARMUT (Cavia porcellus)
Authors: Priyantoro Sigit Tri Yus , Sudjari Sudjari , Karyono Setyawati S.
Published: January 2017

Physalis minima Lâ€™s leaf contains atropin and skopolamin which possess anti cholinergic effect. Cholinergic agent has constrictionÂ effect to the smooth muscle of respiratory tract. In asthma bronchiale there is an airway constriction. This experiment was to observeÂ the effect of Physalis minima Lâ€™s ethanol extract on the relaxation of the guinea pigâ€™s tracheaâ€™s smooth muscle which was induced withÂ histamin by the method of in vitro. Isolated trachea of 5 male guinea pigâ€™s was used as samples in this experiment. Transducer,Â amplifier and mac lab computer were used to create Â the tracheaâ€™s contractionâ€“relaxation curve. The independent variabel wasÂ Physalis minima Lâ€™s leaf ethanol extract dosage andthe dependent variabel was the tracheaâ€™s contraction. 4 dosage of PhysalisÂ minima Lâ€™s leaf ethanol extract were used (1 control, 3 comparable dosage), the dosage of 0.5 % Physalis minima Lâ€™s leaf extractÂ showed significant relaxation of trachea (anova, p<0.05). There was a positive corelation between theincreasing dosage of PhysalisÂ minima Lâ€™s leaf ethanol extract and the relaxation of trachea (regression, r = 0.770, p< 0.05). The conclusion of this study is that theÂ Physalis minima Lâ€™s leaf ethanol extract has positive effect in relaxing isolated trachea of guinea pigâ€™s induced by histamin and thereÂ is a positive correlation between increasing dosageof Physalis minima Lâ€™s leaf ethanol extract and the relaxation of isolated trachea.Â Keywords:trachea smooth muscleâ€™s relaxation, histamine, Physalis minima Lâ€™s leaf ethanol extract.
EFEK KOMBINASI KLOROKUIN DAN N-ACETYL CYSTEINETERHADAP JUMLAH TROMBOSIT MENCIT GALUR BALB/C YANG DIINFEKSI Plasmodium berghei
Authors: Mulyastuti Yuanita , Widijanti Anik , Ali Mulyohadi , Iskandar Agustin , Fitri Loeki Enggar
Published: January 2017

Malaria is the most important of the parasitic diseases of humans. In Indonesia, about more than 70 million people live in area whichÂ is endemic to malaria, about 15 million new case ofmalaria occurred every year. In malaria immune response forms free radicalÂ which assist to eliminate the cause of disease but Â also destroys endothelial cells at various organ. This oxidative damage plays anÂ important role in the development of malarial thrombocytopenia. The aim of this research was to investigate the effect of ChoroquineÂ combine with N-Acetyl cysteine on the degree of parasitemia and platelets amount during malaria infection. Combination ofÂ Chloroquine and N-Acetyl cysteine have been tested by using experimental research method in male Balb/c mice which was infectedÂ by Plasmodium berghei. Measurement of the degree ofparasitemia was done everyday and the amount of the platelet as one of theÂ nonspecific cellular immunity parameter at malaria was calculated once in three days. Treatment group were divided to eight groups,Â group of chloroquine(0,05 mg/gr), group of N-Acetylcysteine with dose 0,25 mg/gr, 0,5 mg/gr, and 1 mg/gr and also combinationÂ group of chloroquine and N-Acetyl cysteine with constant dose of chloroquine(0,05 mg/gr) and various dose of N-Acetyl cysteine(0,25Â mg/gr, 0,5 mg/gr, and 1 mg/gr). One group consistedof infected mice without treatment as control group.
PERBEDAAN PENGARUH PENDIDIKAN SEKS METODE SIMULASI DAN DISKUSI KELOMPOK TERHADAP SIKAPREMAJA PADA UPAYA PENCEGAHAN PERILAKU SEKS MENYIMPANG
Authors: Kumboyono Kumboyono , M Hanafi, , E. P Lestari,
Published: January 2017

Sex education is a process to express message that one of the purpose is to create adolescense positive attitude avoiding incorrectÂ sex behavior. The method used to create adolescensepositive attitude in order to avoid the incorrect Â sex behavior are groupÂ discussion method, demonstration, playing role or simulation method. The purpose of this study was to Â find out the differencesÂ between the influence of giving sex education with simulation method and group discussion of adolescense attitude changes to avoidÂ incorrect sex behavior, and to find out a method that give the biggest score of attitude changes amongthem. The design of this studyÂ was quasi experimental pretest posttest design. While the way to collect samples using multi stage random sampling technique withÂ the number of 90 samples divided into 30 groups of Â control, 30 groups using simulation method of treatment and 30 groups usingÂ discussion group method of treatment. The result from showed that there was difference between score of pretest attitude and scoreÂ of posttest attitude in the group of simulation treatment (t-test p = 0.644) and the discussion group of treatment (t-test p = 0.000), butÂ there was no difference between score of pretest attitude and score of posttest in control group (t-test p = 0.000) Â Î± = 0.05. AnotherÂ finding that there was difference attitude among control group, group of simulation treatment, and group of discussion treatmentÂ (anova p = 0.000) Â Î± = 0.05.
POLA DAN SENSITIVITAS TERHADAP ANTIBIOTIK BAKTERI PENYEBAB INFEKSi SALURAN KEMIH ANAK DI RSU DR SAIFUL ANWAR, MALANG
Authors: Subandiyah Krisni
Published: January 2017

ABSTRACTÂ Urinary tract infection (UTI) is one of the most common bacterial infections affecting children. Early recognition and prompt treatmentÂ of UTIs are important to prevent progression of infections and to avoid late sequeale. The aim of the study was to identify the bacterialÂ agents of urinary tract infections in children and to study sensitivity to antibiotics. Urinary specimens were collected from childrenÂ suffering from urinary tract infections, who were either inpatients or outpatients between January 1999 and December 2003. Of a totalÂ of 563 urine specimens, bacteriuria was found in 276 (49.02%) of patients. Females showed a higher prevalence of infection (51.1%)Â than Â males Â (48.9%). Â Mean Â age Â was Â 63 Â months, Â median age Â was Â 60 Â months Â (range Â 1 Â month Â to Â 12 Â years). Â The microorganismsÂ isolated Â from Â children Â included Â Escherichia Â coli Â (48.9%), Â Acinetobacter Â anitratus Â (9.8%), Â Klebsiella Â pneumoniae Â (9.4%),Â Staphylococcus positive coagulase (5.8%), Proteus mirabilis (4.7%), others (21.4%). Escherichia coli was sensitive to nitrofurantoinÂ (74.8%), Â nalidixic Â acid Â (69.6%), Â cefotaksim Â (48.9%), Â Amoxcillin Â clavulanat Â acid Â (37.8%), Â fosfomicin Â (35.6%), Â gentamicin Â (34.1%),Â ceftriaxone (31.8%), amikacin (19.2%), cotrimoxazole (15.6%), ciprofloxacin (11.1%), cefuroxim (3.7%), netilmicin (8.9%), amoxcilinÂ (2.9%), Â chloramphenicol Â (2.2%), Â ampicilin Â (2.2%). Â Resistant Â to Â ampicillin Â dan Â chloramphenicol Â 97.8%. Â Acinetobacter Â anitratusÂ sensitive to nalidixic acid (62.96%), Amoxcillin clavulanat acid (48.15%), gentamicin (40.74%), co-trimoxazole (33.33%), nitrofurantoinÂ (25.93%), amoxcilin (25.93%), amikacin (11.11%), netilmycine (11.11%), ampicillin (7.40%), ciprofloxacin (7.40%), cefotaxim (7.4%),Â ceftriaxon (7.4%), cefuroxim (3.7%).
AKTIVITAS HEMAGLUTINASI BAKTERI ACINETOBACTER BAUMANNII YANG BERASAL DARI SPESIMEN KLINIK DAN LINGKUNGAN
Authors: Noorhamdani Noorhamdani
Published: January 2017

ABSTRACTÂ Acinetobacter baumannii (Acb) is an opportunistic or a nosocomial pathogenic bacterium which attacks immunocompromised host.Â Colonization and infection often occur while hospitalized and could lead to pneumonia infection, urinary tract infection, meningitis,Â septicemia, and burn or surgical wound infections. In spite of the steady increase of Acb infection cases, little has been revealedÂ about the Acb infection mechanism. The infection process is initiated by the adhesion of bacteria onto the hostâ€™s cell, followed byÂ multiplication, colonization and infection. Adhesion onto the hostâ€™s cell is mediated by the adhesin molecule functioning as theÂ virulence factor. Adhesin is usually found in the form of hemaglutinin protein which is bound to the receptor available at the hostâ€™s cellÂ surface. Target of research is to know weather the bacterium have hemaglutinin protein, by seeing the ability of agglutination redÂ blood of mice 0.5%. Isolate of Acb coming from clinical specimen consisted of urine 35 isolates, sputum 27 isolates, pus 15 isolates,Â and blood 1 isolat.
RISIKO KENAIKAN HEMATOKRIT TERHADAP TERJADINYA RENJATAN PADA KASUS DEMAM BERDARAH DENGUE
Authors: Sumakto Sumakto , Santoso Nurtjahjo Budi , Nugroho Susanto , Kawurjan Siti Lintang
Published: January 2017

ABSTRACTÂ Shock is life threatening feature of DHF it must be manage properly through close clinical and laboratory observations. This was aÂ pre-eliminary study to evaluate hematocrit (Hct) increased where shock occurs on dengue hemorrhagic fever (DHF) or dengue shockÂ syndrome (DSS). The WHO criteria was used to diagnose DHF, with two or more clinical criteria with trombocytopenia (â‰¤ 100.000)Â and Hct increase â‰¥ 20 %. Examination of hemoglobin (Hb), Hct, thrombocytes and leucocytes were done in RSU Dr. Saiful AnwarÂ Central Laboratory everyday during hospitalized. The increase of Hct percentage and Hct/Hb ratio calculation were based on theÂ result of lowest dan highest Hct and Hb examination. The data obtains was analysed with t-test using SPSS version 10.0 programme.Â From 30 DHF cases, 23 (76.66%) non DSS and 7 (23.77%) DSS. The average Hct increase in all patients from serial examinationsÂ was 21.09% (SD= 2.32%). However, in 7 DSS patients the average Hct increase was 23.79% (SD= 3.84%) higher than the 23 nonÂ DSS patients (20.28%; SD= 0.25%). It was observed that the Hct increase in DSS patients was higher than that for non DSS patients.Â This high Hct level of 23.79% increases the likelihood of shock by 2.5 times compare with an Hct rise of 20.28%. There was aÂ significant difference in the highest and lowest Hct/Hb ratio between DSS and non DSS cases (p= 0.000).Â Keywords : dengue hemorrhagic fever, dengue shock syndrome, hematocrit increase, Hct/Hb ratio
GAMBARAN KLINIS DAN LABORATORIUM SINDROM SYOK DENGUE RAWAT PICU RSU DR. SAIFUL ANWAR MALANG
Authors: Budhy Setya , YS Mardhani , Muid Masdar
Published: January 2017

ABSTRACTÂ Dengue shock syndrome (DSS) is a clinical emergency case with still high mortality rate. During five years period (1January 1997â€“31Â December 2001) total case of SSD triaded in PICU room Medical Faculty Brawijaya University/ Saiful Anwar Hospital Malang wereÂ thirty two patients. They were referred from Malang regency 9 patients (28%), Malang city 23 patients (72%). The most group age 6 â€“Â 10 years 14 patients (44%), < 5 years 13 patients (41%), 11 â€“ 14 years 5 patients (15%). SSD is devided in DBD grade III 14 patientsÂ (44%), DBD grade IV 18 patients (56%). Laboratory finding total leucocyt count < 4000/mm3Â 8 patients (25%), Â 4000 â€“ 10000/mm3Â 24Â patients (75%). Total thrombocyt < 50000 / mm3Â 22 patients (69%), 50000 â€“ 100000/ mm3Â 10 patients (31%). Hematocrit > 42% allÂ patients (100%). Clinical sign found in SSD patients quickly and fine pulse 14 patients (44%), cold extremities 32 patients (100%),Â pulse not palpable 18 patients (56%). Blood tension : unmeasured 18 patients (56%), hypotension 18 patients (56%). Death patientsÂ 13 (41%) recovery patients 19 (59%). All SSD patients Â (100%) Â were death by complication of occult bleeding, pulmonary edema,Â respiratory failure.
HUBUNGAN ANTARA DERAJAT OBSTRUKSI SERANGAN AKUT ASMA DENGAN KADAR IgE, IFN- DAN IL-4 TOTAL SERUM
Authors: Kusuma HMS. Chandra , Kalim Kusworini Handono , Riawan Wibi , Muid Masdar
Published: January 2017

ABSTRACTÂ Acute bronchial asthma is a common medical emergency the world over. There now exists compelling evidence of a role for Th2-Th1Â paradigm in the pathogenesis of asthma in children. We hypothesized that childhood asthma is associated with the activation of Â Th2-Th1 lymphocytes whose products regulate at least in part, the expression of IgE, IFN-Î³ and IL-4 and thereby disease severity. OurÂ aims, therefore were to compare the level of total IgE, total IL-4 and total IFN-Î³ in serum from asthmatic and non asthmatic controlÂ children matched for age and sex, and to attempt to correlate the IgE, IL-4, and IFN-Î³ total level of serum in the asthmatics childrenÂ with disease severity. Fifty one children with acute asthma exacerbation were compare with thirty one no asthmatics normal childrenÂ matched for age and sex. The level of IgE, IL-4, and IFN-Î³ were measured using Elisa. Asthma severity was assessed by a symptomÂ score and spirometri. The level of IgE and Il-4 in the serum of the asthma were elevated as compared to the non asthmatic normalÂ controls, whereas the IFN-Î³ was decreased. There was a significant correlation between elevated levels of IgE and IL-4 with the acuteÂ asthma exacerbation severity, whereas the decreased level of IFN-Î³ was not. Conclusions. The increased levels of IgE , IL-4 and theÂ ratio of Â IL-4/IFN-Î³ play a crucial role in the acute asthma exacerbation severity.
DIARE ROTAVIRUS PADA ANAK DIBAWAH USIA 3 TAHUN YANG DIRAWAT DI RSU DR. SAIFUL ANWAR MALANG TAHUN 2005 (PRELIMINARY STUDY)
Authors: Santoso Nurtjahjo Budi , Hamid Aulia Abdul , Santoso Sanarto
Published: January 2017

ABSTRACTÂ Rotavirus is the most common cause of acute diarrhea among children worldwide. The majority of the cases required hospitalization.Â Epidemiologic pattern and clinical manifestation could be helpful in establishing the proper diagnosis and management. To find outÂ prevalence and the clinical pictures of rotavirus diarrhea among children under three years of ages with acute diarrhea admitted in theÂ Department of Child Health Dr. Saiful Anwar General Hospital. The stools of children under three years of age with acute diarrheaÂ between March 1stÂ and May 1st, 2005 were assessed for rotavirus using Latex agglutination test (Slidex, Rota K2, bio Merieux). Age,Â sex, clinical sign and symptoms and breast-fed were recorded. The severity of acute diarrhea was estimated using WHO criteria.Â Statistical analysis were performed using EpiInfo 2000 program with x2Â or x2Â for trend. From the 40 patients with acute diarrhea wereÂ found 16 patients (40%) with rotavirus positive, both male and female were 8 patients (50%). Distribution of rotavirus positive patientsÂ in age group were 0-5 months 3/16 (18,7%), 6-11 months 6/16 (37,5%), 12-23 months 6/16 (37,5%) and 24-36 months 1/16 (6,3%).Â Clinical manifestations showed that most children had fever (75%), vomiting (87.5%) and dehydration (87.5%). Rotavirus infectionÂ among breast-fed patients were found less than bottle-fed patients.
PENGARUH KADAR TROMBOSIT, HEMATOKRIT, HEMOGLOBIN DARAH DAN PROTEIN URIN PADA IBU PREEKLAMSI /EKLAMSI TERHADAP NILAI APGAR BAYI YANG DILAHIRKAN
Authors: Kawuryan Siti Lintang
Published: January 2017

ABSTRACTÂ Preclapmsi or eclampsia is one of the risk factor for asfiksia on newborn that can predicted by lower Apgar score. The aim of thisÂ research Â is Â to Â know Â the Â influence Â of Â the Â trombocyte, Â hematokrit, Â hemoglobin, Â and Â urinary Â protein Â examination Â of Â preclampsi Â orÂ eclampsi mother to babyâ€™s Apgar score. This research was a diskriptive-cross sectional retrospective study with Chi- square test,Â Fisher test x2 for trend statistic analysis. Total sample was 100 which choosen by simple random sampling. The parameter of thisÂ study was trombocyte, hematokrit, hemoglobin, and urinary protein examination of preclampsi or eclampsi mother and babyâ€™s ApgarÂ score. There was a significant influence relationship between the raise of blood hematocrit (p=0,0243), the decrease of the bloodÂ trombocyte (p= 0,0175) and the high level of proteinuria (p=0,0154) of preclampsi or eclampsi mother Â to babyâ€™s Apgar score. In theÂ other hand, hemoglobin (p =0,3589), SGOT (p=0,5447),SGPT (p= 0,4850), Ureum (p = 0,1964), kreatinin (p= 0,3415) level was notÂ significantly influence. The conclusion of this reseach is hematokrit â‰¥ 38 % and urinary protein â‰¥ 4+ on preclampsi or eclampsi motherÂ are usefull for predicting lower Apgar score of the neonate with relative risk 7,609.Â Keyword: preclampsi or eclampsi, trombocyte, hematokrit, hemoglobin, and urinary protein examination, Agar score
PENATALAKSANAAN SINDROMA MAYER ROKITANSKY KUSTER HAUSER (SINDROMA MRKH) DENGAN SINDROMA KLIPPEL FEIL
Authors: Wiyasa IW Arsana , Mukminah Aisyatul
Published: January 2017

ABSTRACTÂ It was reported that a 19 year old woman, suffered from Muller duct agenesis. The patient came to RSSA, complained about primaryÂ amenorrhea and assimetrical of head position. Tuba, uterus and 2/3 proximal vagina were not formed. Both of ovaries seemedÂ normal. Based on vaginal sondage, the vagina canal is only 1.5 cm. Secondary sexual characteristics developed normally. By skullÂ and cervical X â€“ ray, it was found fusion of vertebrae cervical 3, 4. The vagina and the uterus are not present, but the tuba and theÂ ovarium are normal; this case is known as Mayer Rokitansky Kuster Hauser Syndrome. Moreover, it is accompanied by anotherÂ congenital defect, i.e. fusion of vertebrae cervical 3 and 4, which is called Klippel Feil Syndrome. In the exploration, it was found thatÂ there was a constitution of cromosom 46,XX. It has been done hormonal examination: FSH, LH, estrogen, prolactin and was obtainedÂ testosteron < 127.8 ng/dl. The patient was grews up as a woman. Her behavior, attitude, emotion and sexual behavior are likely aÂ woman. Â We plan to perform and suggest her to adopts a child. To treat the Klippel Feil, it is important prevention of the neck traumaÂ and complication of neurology and arthritis.Â Key word : Mayer Rokitansky Kuster Hauster Syndrome, Klippel Feil Syndrome, vaginoplasty
PENGARUH PEMBERIAN TEMULAWAK PADA LAMBUNG TIKUS YANG MENGALAMI ULKUS PEPTIKUM AKIBAT INDUKSI INDOMETASIN
Authors: Indraswari Cokorde Istri , Kalsum Umi , Sudjari Sudjari
Published: January 2017

ABSTRACTÂ The flavonoid content of Curcuma xanthorriza has an anti inflamatory effect. Inflamation is the basic mechanism in the occurrence ofÂ indomethacine induced peptic ulcer. The purpose of this research was detect the effect of the administration of Curcuma xanthorrizaÂ decoction in reducing the occurrence of indomethacine induced peptic ulcer. The research methodology used post test control groupÂ design. Randomly selected sample of 20 male wistar rat were classified into four groups. Group I (positive control, received 30 mg/kgÂ bodyweight indomethacine), group II (dosage 1, received 30 mg/kg bodyweight indomethacine and 1,3 g/kg bodyweight CurcumaÂ xanthorriza Â decoction), Â group Â III Â (dosage Â 2, Â received Â 30 Â mg/kg Â bodyweight Â indomethacine Â and Â 2,6 Â g/kg Â bodyweight Â CurcumaÂ xanthorriza decoction), and group IV (dosage 3, received 30 mg/kg bodyweight indomethacine and 5,2 g/kg bodyweight CurcumaÂ xanthorriza Â decoction). Â Indomethacine Â and Â Curcuma Â xanthorriza Â was Â given Â by Â intragastric Â administration. Â The Â parameter Â to Â beÂ measured was the number of macroscopic gastric hemorrage lesion, because gastric hemorrage is the early manifestation of pepticÂ ulcer. The result of this research was there is a significant difference in the number of macroscopic gastric hemorrage lesion betweenÂ group I and the other three group (F test, p<0,05), and there is no significant difference for those of group II, III, and IV (F test,Â p>0,05). Conclusion: Curcuma xanthorriza can reduce the occurrence of peptic ulcer.Â Key words: Indomethacine, Curcuma xanthorriza, Peptic ulcer, Gastric hemorrage lesion
EVALUASI HASIL PELATIHAN DAN PENDIDIKAN UNTUK PENANGANAN PRA RUMAH SAKIT TERHADAP PENDERITA CEDERA
Authors: Soemarko M.
Published: January 2017

ABSTRACTÂ The Â purpose Â of Â organized Â trauma Â system Â management Â of Â pre Â hospital Â care Â of Â seriously Â injured Â patients Â is Â to Â ensure Â the Â earlyÂ intervention and transfer savely the patients to the best equipped facility to care of their injuries. The aims this research is to evaluateÂ the results and the effectiveness of the training and education of pre hospital management in Saiful Anwar Hospital. Â The method thisÂ research are an observational study of injured traffic accident patients preHospital care in Saiful Anwar General Hospital Malang.Â Training and education have been done intensively and continuously after August 1999 until now. The comparation was between 1stÂ April until 31stÂ Juli 1999 and 1stÂ April until 31stÂ Juli 200. The result of this research, a significant progress in pre hospital treatment,Â ambulance transportation and communication between field attendance and the trauma center. But significantless of progression inÂ pre hospital medical records. Only reveral system from health center was significant developed. The intensive training and educationÂ of pre hospital management to the injured patient had a significant good results. The training and education must be continued andÂ developed for a better results in the future. Â Key words : Injured patients, pre hospital care, training and education.
TRANSFEKSI DNA KE DALAM MITOKONDRIA SEL BETA PANKREAS TIKUS DAN SEL PRIMER MYOBLAST MANUSIA: LANGKAH MENUJU REKAYASA DNA MITOKONDRIA DAN TERAPI GEN
Authors: Lyrawati Diana
Published: January 2017

The delivery of an exogenous or modified DNA into the mitochondria of mammalian cells has been proposed as an alternative way toÂ prevent or modify mitochondrial genetic defect. In Â this study, a lipofection method was developed to transfer exogenous DNA intoÂ mitochondria of BRIN BD11 cells, a rat beta pancreas cell line, and human myoblast primary cells. An artificial mini-mitochondrialÂ genome carrying a reporter gene encodes for a mitochondrial green fluorescent protein (mtGFP) was usedto track the fate of theÂ exogenous DNA following its transfection into cellular mitochondria. Epifluorescence microscopic observation was carried out toÂ detect the green fluorescence resulted from the GFPexpression. Immunohistochemical assays were also performed to validate andÂ confirm the GFP expression. Collectively, the results indicate that the exogenous DNA pmtGFP could be Â delivered into theÂ mitochondrial compartment and was functional withinthe mitochondria of BRIN BD11 and human myoblast cells. Such achievementÂ is a significant progress as both the artificial DNA construct and the mitochondrial transfection method could serve as a model toÂ study the dynamic of mutant mtDNA as well as to provide a basis for the development of gene therapy for human mitochondrialÂ diseases.Â Key words: DQAsome, pmtGFP, beta pancreas cell line, human myoblast primary cells
PENGARUH EKSTRAK BIJI NIMBA (Azadirachta indica) TERHADAP PENURUNAN DERAJAT PARASIT DAN JUMLAH HEMOZOINPADA KULTUR Plasmodium falciparum
Authors: Aini Noer , Soebaktiningsih Soebaktiningsih , Fitri Loeki Enggar , Kalsum Umi , Sumarno Sumarno
Published: January 2017

Malaria infection is still one of world healthâ€™s problems that cause a high death rate (20.9% - 50%). One of the reason is PlasmodiumÂ falciparum resist to conventional anti-malarial drugs. Neem seeds extract had been reported has antimalarial effect by decreasingÂ parasitemia, but there has not been any report on its effect in inhibition hemazoin formation. The aimof this research was to find theÂ effect of Neem seeds extract on parasitemia and hemazoin level in Plasmodium falciparum culture. Laboratory experiment was doneÂ by using Papua isolate of Plasmodium falciparum (2300) from NAMRU 2 Jakarta. After synchronized, malarial culture was divided intoÂ 4 groups namely Control group (culture medium only), Chloroquine group, Artemisinin group, and Neem seeds extracts group. EachÂ treatment group was devided into 5 drug doses of 6.25 Âµ/ml, 12.5 Âµ/ml, 25 Âµ/ml, 50 Âµ/ml and 100 Âµ/ml respectively. Parasitemia wasÂ measured by Pyridine-hemochrome methods using spectrophotometer Â Î»560 nm. Statistical analysis was done involving one-way-ANOVA followed by Tukey HSD and Pearsonâ€™s Correlation. A significant difference was found between control and treatment groupsÂ in parasitemia and hemozoin level. Different dose in treatment groups didnâ€™t show any significant difference in both parasitemiaÂ (p=0.99) and hemozoin level (p=0.985). Tukey test between treatment groups didnâ€™t show a significant difference decrease ofÂ hemazoin level and parasitemia (r=0.970). The conclusion was Neem deeds extract can inhibit P. falciparum growth by decreasingÂ parasitemia and hemazoin level.Â Key words: Neem seeds extract, parasitemia, hemazoin level, P. falciparum
EFEK EKSTRAK BUNGA KENANGA (Canangium odoratum) SEBAGAI AGONIS PADA RESEPTOR ADRENERGIK-Î² Î²Î² Î²DI PARU TERPISAH MARMUT (Cavia porcellus)
Authors: Charisti Pherenice , Loekito Retno M , Karyono Setyawati S
Published: January 2017

The cananga flower (Canangium odoratum) is one of the herbal medicine used for asthma bronchiale. Cananga extract have beenÂ proved to relax the isolated guinea pigâ€™s tracheal Â and bronchus smooth muscle. The relaxation of the tracheal smooth muscle couldÂ be inhibited by propanolol 10-9M, however propanolol 10-9M could not inhibit the relaxation of the bronchialsmooth muscle. ThereforeÂ the objective of this study is to investigate the effect of cananga extract on relaxation of isolated Â guinea pigâ€™s lung strip through Â Î²-adrenergic receptor. Three different dose of propranolol was used as Â Î²-adrenergic receptor antagonist. This study was anÂ experimental research using guinea pigâ€™s isolated lung strip. The control group was given histamine and cananga extract. The firstÂ group of treatment was administrated histamine, propanolol 10-9M and cananga extract. The second group of treatment was givenÂ histamine, propanolol 10-8M and cananga extract. The third group of treatmentwas given histamine, propanolol 10-7M and canangaÂ extract. The results of this study showed that cananga extract caused relaxation of lung strip and there was a reduction in theÂ relaxation of lung strip after administration of propanolol. The reduction in relaxation lung strip caused by propranolol inhibition wasÂ found to be significant using regression testing. In conclusion, cananga extract works as a partial agonist to Î²-adrenergic receptors inÂ bronchial smooth muscle of guinea pigs since the dosage response curve showed shift to the right but it was not paralel.Â Keyword :cananga extract, relaxation of lung strip, Î²-adrenergic receptor.
LUAS DEFEK MENINGOKEL BERHUBUNGAN DENGAN KADAR TRANSFORMING GROWTH FACTOR Î²1 (TGF-Î²1)DAN INSULINE-LIKE GROWTH FACTOR-1 (IGF-1) DALAM TULANG
Authors: E.S. Moch. Istiadjid
Published: January 2017

Meningocele pathogenesis is based on skull defect that occurs since the first three month of fertilization period. Through that defect,Â mening, cerebrospinal liquid, and cerebral parenchym is protruded. Meningocele can cause by folic aciddeficiency that had provedÂ correlation with TGF-Î²1 and IGF-I level, both in maternal blood or baby ratâ€™s skull. Folic acid deficiency also causes increasing theÂ number of apoptosis and necrosis cells death in babyâ€™s skull. TGF-Î²1 and IGF-I one growth factors thatstimulate bone synthesis. TheÂ purpose of this study is to explore the correlationbetween TGF-Î²1 and IGF-I level in skull on side defect of meningocele patients andÂ the wide of skull defect to obtain the role of the Â two growth factors in meningocele teratogenesis perspectively. Eight meningoceleÂ patients that were performed excision by standard procedure have taken a few of bone speciment on sidedefect to count TGF-Î²1 andÂ IGF-I levels with immunochemistry technic. Wide defect was determined by measuring defectâ€™s diameter, using Martin anthropometer.Â The correlation between TGF-Î²1 and IGF-I skull level and defectâ€™s wide was analyzed by SEM (structuralequation modeling) statistic.Â There was significant negative-correlation between that variable, that mean the lower of the two growth factors level is wider of skullÂ defect. TGF-Î²1: r = -0.648, p =0.009; IGF-I: r = -0.426, p =0.025.Â Key words:Meningoencephalocele, Skull defect, TGF-Î²1, IGF-I.
HUBUNGAN ANTARA DERAJAT OBSTRUKSI SALURAN NAFAS SERANGAN AKUT ASMA DENGAN JUMLAH SEL-SEL INFLAMASI DARAH TEPI
Authors: Kusuma HMS. Chandra , Kalim Kusworini Handono , Muid Masdar
Published: January 2017

There now exists compelling evidence of a role for Â cell-mediated immunity in the pathogenesis of asthma, but little information isÂ available as to what extent this process participates in the disease severity. The hypothesized of this reseach that the severity ofÂ acute asthma exacerbation in children is associatedwith the activation of T-lymphocytes whose products regulate, at least in part, theÂ mobilization and recruitment of eosinophyls and thereby disease severity. The aims of this research, therefore, were to compare theÂ peripheral blood T-lymphocytes from acute asthmaticand no asthmatic normal control children matched for age and sex, and toÂ attempt to correlate the percentages of T-lymphocytes in the asthmatic with the numbers of peripheral Â blood eosinophyls and withÂ disease severity. Fifty one children with acute asthma exacerbation were compared with thirty one no asthmatic, normal childrenÂ matched for age and sex. Peripheral blood CD4+ and Â CD8+ T-lymphocytes was measured using immuno histochemical staining.Â Peripheral blood eosinophils were measured using anautomated laser cytometer. Asthma exacerbation severity was assessed by aÂ symptom score and spirometri. The absolute numbers Â of eosinophils and CD4+ T-lymphocytes of the asthmatic were elevated asÂ compared to the non-asthmatic normal control, whereas the numbers of CD8+ T-lymphocyte decreased significantly.
OUTCOME SINDROM NEFROTIK PADA ANAK â€“ PENELITIAN PROSPEKTIF STUDI COHORT
Authors: Subandiyah Krisni
Published: January 2017

Nephrotic syndrome (NS) in children is a common recurrent disease. Most of the cases are due to minimal change disease with aÂ favorable outcome. The mayority of children have minimal change disease and 90 â€“ 95% will respond to steroid therapy. Response toÂ steroid therapy carries a greater prognostic weightthan the histologic features. The aim of the studywas to describe the outcome ofÂ Nephrotic Syndrome in children and to determine risk factors for these complications. Children with NSwere admitted to PediatricÂ Department Saiful Anwar Hospital Malang, January 2000 - December 2003 evaluated prospectively for one year. Data was sought onÂ steroid responsiveness, remission, relapse rates, infection, and trombosis. Patients were classified into five categories. Including:Â relapse, infrequent relapsing (IFRNS), frequent relapsing (FRNS), steroid dependent (SDNS) and steroidresistant (SRNS). BaselineÂ age, gender, clinical manifestation and laboratory finding were used to predict category of the disease. Definition of NS, remission andÂ relapse were based on the ISKDC guidelines. Of 91 children with NS, 75 (82,4%) children had steroid sensitive nephrotic syndromeÂ (SSNS) while 16 (17,6%) children were classified SRNS. In the SSNS group 42 (56%) of children were over 6 years of age and thereÂ were 51 (68%) males and 24 (32%) females.
KEDOKTERAN EMERGENSI TANTANGAN, HARAPAN, DAN MASA DEPAN
Authors: Dradjat Respati Suryanto
Published: January 2017

The progress of science and technology in globalization era, forcing us to make-up the quality of education and services in the fild ofÂ Emergency Medicine (EM). As one of the teaching hospital in Indonesia, Saiful Anwar Hospital â€“ Brawijaya University have developedÂ this education programe. Various challenge, and opportunity have and will be faced to reach the futureof Indonesian Medical servicesÂ to be able to compete in the era of global standardKey words:emergency, education, services
PENGARUH PEMBERIAN KAPSUL EKSTRAK GARLIK TERHADAP PERUBAHAN TEKANAN DARAH DAN JUMLAH TROMBOSIT PADA PENDERITA PREEKLAMPSI RINGAN
Authors: Irwanto Yahya , Wahyudi Imam , Soewarto Soetomo
Published: January 2017

The objectives is to investigate the efectivity of Â extract garlic capsule compared to standart therapytoward the changes of bloodÂ presure and thrombocyt level in the mild-preeclampsy patients. This study was a single-blind randomised clinical trial. The subject ofÂ study were the mild-preeclampsy pregnant women within 20 â€“ 36 weeks of gestational age whose came to the Poli Hamil RSUD dr.Â Saiful Anwar. The subject divided into 2 groups, the treatment group received both of the standart therapy of mild-preeclampsy andÂ extract garlic capsule, while the controlling grouponly received the standart therapy of mild-preeclampsy. After 2 weeks, the bloodÂ pressure and the trombocyt count was evaluated. Thesystolic blood pressure of the treatment group wasdecrease at average ofÂ 10.12 mmHg, from 140.25 Â± 5.57 before treatment to 130.12 Â± 10.84 mmHg after treatment, while in thecontrololling group thereÂ was an increase at average of 5.56 mmHg from 140.44Â± 6.14 mmHg to 146Â±13.81 mmHg. The T Test and ANCOVA analyzingÂ showed a significant result (P value were 0.001 and0.0008).
SINYAL TRANSDUKSI DARI BROMELAIN SEBAGAI ANTIINFLAMASI PADA UDEMA TELAPAK KAKI TIKUS YANG DISEBABKAN OLEH KARAGEN
Authors: Sudjarwo Sri Agus
Published: January 2017

The signal transduction of bromelain as antiinflamatory in carragenan-induced rat paw edema were investigated. SpragueÂ Dawley Rats were divided into the control groups which were given saline, and bromelain groups which received doses ofÂ 10, 20 and 40 mg/kg bromelain (peroral) respectively. This was followed by the administration of 1 % caragenin throughÂ the intraplantar route 30 min after administration Â bromelain or saline. After the carrageenan injection paw volume,Â prostaglandin (PGE2) production and cyclooxigenase (COX)-1 and COX-2 expression was measured. The bromelain inÂ doses of 10, 20 and 40 mg/kg showed 11.3; 45.1 and Â 56.3 % inhibition of paw edema respectively at the Â end of threeÂ hours. The increase in Prostaglandin (PGE2) levels after carrageenan injection was significantly prevented byÂ preadministration of the bromelain at 20 and 40 mg/kg but not bromelain at 10 mg/kg. Bromelain a dose-dependentÂ inhibited both COX-1and COX-2 activity in carrageenin-induced inflammation. Bromelain inhibited COX-2 Â than COX-1Â stronger activity. These results suggest that antiinflammatory effect of bromelain is due to its ability to inhibit PGE2production could be mediated by inhibition mainly on COX-2 than COX-1 activity.Â Keywords: Bromelain, Cyclooxigenase, Prostaglandin
KEMAMPUAN SEL LIMPA NORMAL MENCEGAH TERJADINYA PENYAKIT AUTOIMMUNE PADA MENCIT IL-2RÎ² Î²Î² Î² -/-
Authors: Rifaâ€™i Muhaimin
Published: January 2017

Adoptive transfer is a potentially curative treatment for both inherited and acquired diseases of hematopoieticÂ compartment and organ failure. The aim of this experiment was to know the potency of normal unfractionated spleen cellsÂ to prevent pathological autoimmunity in IL-2RÎ²-/-mice. Here, we show that the normal unfractionatedspleen cells have aÂ capacity to prevent autoimmune diseases when adoptively transferred to IL-2RÎ²-/-Â mice. Intravenously, and adoptivelyÂ transferred of normal unfractionated spleen cells (107) to IL-2RÎ²-/-mice (3 wks) gave an evidence on preventing the lethalÂ phenotype due to autoimmune disease in IL-2RÎ²-/-mice. The donor cells have a capacity to reverse the status of recipientÂ cells from memory to naÃ¯ve type. In addition, donorcells also have a capacity to regulate the development of granulocyteÂ cells into normal level of homeostasis. These findings suggest that normal unfractionated spleen cells Â could in the futureÂ be used in clinical settings to cure autoimmune diseases.Â Keywords :autoimmune, spleen cells, IL-2RÎ²-/-, mice
PERUBAHAN KADAR SITOKIN DAN MOLEKUL AGREGASI PADA BERBAGAI TINGKAT TROMBOSITOPENIA PADA DEMAM BERDARAH DENGUE
Authors: Djunaedi Djoni
Published: January 2017

The uncovering of the changes in the concentration of aggregation molecules (vWF, PGI2) and cytokines (TNFÎ±, IL-1Î²,Â IL-6) in different levels of thrombocytopenia in DHF patients can be used as the basis in predicting the occurrence ofÂ thrombocytopenia. A prospective-observational studywas undertaken utilizing a 3-day sequentially drawn vein blood ofÂ inclusive DHF patients. The TNFÎ±, IL-1Î² and IL-6 test was conducted utilizing the quantikine high sensitivity humanÂ cytokine immunoassay, and the vWF and PGI2test was conducted utilizing the ELISA procedure. Â The multivariate andÂ discriminant analyses tests on the deltas between day 1 and 2 observations, and between day 2 and 3 observations ofÂ the 6 variables showed Wilksâ€™ Lambda =0.638 with p=0.008 and platelets and vWF as the most powerful discriminatingÂ variable (70.5.%). The findings of this study indicated that in DHF patients (1) the changing of the concentration of TNFÎ±,Â IL-1Î²and IL-6 cytokines do not play a significant role Â in the mechanism of platelets aggregation, (2) platelets countÂ decreases in a condition in which vWF facilitated platelets aggregation, (3) the changing of a positive contribution of vWFÂ causes a determination of the process of platelets aggregation, and (4) a positive changing of vWFâ€™s concentration can beÂ used as a prognostic indicator of a negative changing of platelets count..Â Key words: Dengue Hemorrhogic Fever, thrombocytopenia, vWF
SKOR KEBOCORAN VASKULER SEBAGAI PREDIKTOR AWAL SYOK PADA DEMAM BERDARAH DENGUE
Authors: Setiati Tatty Ermin , Retnaningsih Anastasia , Supriatna Mohmad , Soemantri Agustinus
Published: January 2017

The prediction of shock in Dengue Hemorrhagic Fever is difficult to made, hence, is difficult to detect Â shock as early asÂ possible. This results in delayed management and ultimately can cause death. Serum levels of protein, albumin,Â hematocrit, and PEI which are markers of vascular leakage hoped to be able to be used as predictor of Â shock in DHF.Â The aim of this study was to develop a scoring system, the Vascular Leakage Score (VLS) that could be used as theÂ predictor of shock and to define the probability ofshock from each total score. This was a cross-sectional, observationalÂ analytic study, in RSDK, Semarang from 2001-2003. The samples were 138 children with DHF, aged 3-14 years old,Â divided into 52 cases of DHF without shock, and 76 cases of Dengue Shock Syndrome. Serum levels of protein, albumin,Â PEI, and hematocrit were obtained at admission. Then, a classification was made upon the four parameters mentionedÂ above, based on the ROC curve analysis from the previous studies, and based on the WHOâ€™s criteria. To develop aÂ formula for VLS, we gave points-weight for each parameter to calculate the Î²-coefficient, then continued with calculationÂ of DSS probability based on total combination of the four categories above, using a logistic-regression analysis ofÂ multivariate.
HUBUNGAN KADAR SENG SERUM DENGAN TINGGI BADAN ANAK SEKOLAH DASAR PENDERITA GAKY
Authors: Setijowati Nanik
Published: January 2017

The incidence goiter starts to the extend in Urban area. Not all Elementary School children with goiterexperience ofÂ pursued growth. This indicates that besides low iodine content, there are other elements which also influence growth.Â This research intends to study the relationship between zinc the level of serum and height on elementary school childrenÂ (8 â€“ 12 year) in endemic goitre areas, in Malang Municipality. Data ware collected with cross-sectional study from AugustÂ to December 2000. Blood and urine sample of twenty Â children of each group were examined for zinc serumand iodineÂ urine concentration. Information about diet pattern, socio-economical condition were obtained by structured questionairreÂ for mother and children.This research used Independent T-test, Person Correlation test, and Multiple Regression forÂ statistics analysis. The result showed that: (1). There were significant relationships between energy (r= 0.364, p = 0.012);Â protein (r = 0.481, p = 0.001) and zinc intake (r =0.491, p = 0.001) with height; (2). There were significant difference inÂ energy (p = 0.014), carbohydrate (p = 0.042), lipid( p = 0.014), protein (p = 0.003), and zinc intake(p = 0.004) betweenÂ the two groups examined. The conclusion was that lower height for age was possibly ascribed to lack of energy, protein,Â iodine and zinc intake.Â Key words:zinc serum, iodine urine, height for age, and goiter
PERANAN MAKROFAG PADA PROLIFERASI, DIFERENSIASI DAN APOPTOSIS PADA PROSES HEMATOPOISIS (PENELITIAN PADA LIMPA JANIN TIKUS DAN ASPIRAT SUMSUM TULANG MANUSIA)
Authors: Widjajanto Edi
Published: January 2017

Macrophage stimulates growth of surrounding cells by various cytokines and growth factors synthesized Â and eliminateÂ apoptotic cells by its phagocytes activity. This study was to evaluate the evidence of macrophage as regulator cells duringÂ haematopoiesis. Haematopoietic activity assessed microscopically by proportion of various haematopoietic blood cells toÂ total nucleated blood cells on imprint preparation of fetal ratus (Wistar) spleen and human marrow aspirate, after Wrightâ€™sÂ stain coloration. Fetal ratus spleen and human marrow aspirate were used to evaluate macrophage as a stimulator cellÂ and suppressor cell respectively. During prenatal period, the proportion of macrophage increased at 14thdays (1.3 Â±Â 0.9%), 16thdays (7.6 Â± 1.8 %), 18thdays (12.9 Â± 2.8 %) and 20thdays prenatal gestation periods (14.1 Â± 3.1%). Thismacrophage increment was associated with the increase of other blood cells, except the proportion of lymphoid cell whichÂ decreased. During postnatal period the macrophage proportion decreased (11.0 Â± 1.7 %), and other bloodcellsÂ proportion continuously increased except lymphoid cells which decreased. Many haematopoietic islands representingÂ active haematopoietic process were found at 14thdays of fetal rat spleen. Macrophage in human hypocellular marrow (n =Â 9) increased and it exceed other blood cells proportion (29 %, p < 0.001) and contained phagocytosed apoptotic bodies.Â This study concludes that high macrophage regulates Â haematopoiesis when it was proportionally low and regulateÂ haematopoiesis when it was proportionally high.Â Keywords:Macrophage, Apoptosis, Haematopoiesis
HUBUNGAN KADAR GULA DARAH SAAT MASUK RUMAH SAKIT DENGANCARDIAC EVENTS PADA PENDERITA INFARK MIOKARD AKUT DI RS DR SARDJITO YOGYAKARTA
Authors: Irawan Bambang , Suharno Suharno , Rochmah Wasilah
Published: January 2017

Hyperglycaemia is common in patients with acute myocardial infarction with and without diabetes mellitus. There is aÂ positive relationship between hyperglycaemia at thetime of event and highly incidence of mortality and morbidity afterÂ acute myocardial infarction. Consequently, understanding the possible mechanisms through which hyperglycaemiaÂ worsens the prognosis of acute myocardial infarction, as well as effectiveness of its control during acute myocardialÂ infarction, seems to be a great relevance. This study to investigate wether a relationship exists between blood glucoseÂ level on admission and cardiac events in non diabetic patients after an acute myocardial infarction. Method, Â a cohortÂ prospective observational study was done on acute myocardial infarctionâ€™s patients who were hospitalized in ICCU DRÂ Sardjitoâ€™s hospital from March 2002 until October 2004. Subject who met inclusion and exclusion criteria were divided intoÂ 2 groups, the group in which blood glucose level onadmission was â‰¤ 140 mg/dl and the group with bloodglucose onÂ admission was > 140 mg/dl. Cardiac events as well as mortality, cardiac failure, reinfarction and cardiogenic shock wereÂ observed for 6 months. There were 95 subjects, 93 males and 2 females.