bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Pemberian Diet Isokalori Tinggi Serat terhadap Tingkat Satiety pada Kelompok Usia Dewasa Awal
Authors: Nabila Maura Tirta , Tsani A. Fahmy Arif , Rahadiyanti Ayu , Dieny Fillah Fithra
Published: September 2021

Latar Belakang: Belum banyak penelitian yang membandingkan pengaruh diet tinggi serat larut air dan diet tinggi serat tidak larut air terhadap tingkat satiety.Tujuan:Menganalisis pengaruh pemberian diet isokalori tinggi serat terhadap tingkat satiety pada kelompok usia dewasa awal status gizi normal.Metode: Penelitian eksperimentaldengan rancangan pre-post group design. Subjek penelitian adalah 16 orang dewasa awal usia 20-23 tahun (10 perempuan dan 6 laki-laki) yang diambil secara consecutive sampling. Semua subjek diberikan 2 jenis diet isokalori dengan rasio serat larut air : serat tidak larut air sebesar 3:2 dan 1:3 dengan masing-masing wash out period selama 1 hari. Energi yang diberikan sebesar 20% dari total kebutuhan masing-masing subjek. Variabel yang diukur adalah tingkat satiety yang terdiri dari tingkat desire to eat, hunger, fullness dan prospective food consumption/PFC menggunakan kuesioner Visual Analogue Scale. Analisis statistik menggunakan paired t-test, wilcoxon, mann-whitney dan independent t-test.Hasil: Diet tinggi serat larut air memiliki efek lebih lama 1 jam dalam menekan hunger dan desire to eat dan memiliki efek lebih lama 30 menit dalam menekan PFC dibandingkan diet tinggi serat tidak larut air, namun kedua diet tersebut sama-sama baik dalam meningkatkan fullness hingga 3 jam setelah intervensi.Kesimpulan: Pemberian diet tinggi serat dapat menekan tingkat desire to eat, hunger, PFC dan meningkatkan fullness. Diet tinggi serat larut air mempunyai efek lebih lama terhadap tingkat satiety dibandingkan diet tinggi serat tidak larut air.
Perbedaan Keragaman Pangan, Pola Asuh Makan, dan Asupan Zat Gizi Makro pada Balita dari Ibu Bekerja dan Ibu Tidak Bekerja
Authors: Sari Hesti Permata , Permatasari Lilis , Putri Widya Ayu Kurnia
Published: September 2021

Background: Toddlers are a group that is vulnerable to experiencing nutritional problems. The nutritional status of toddlers is very dependent on the role of caregivers, especially mothers. Business women have less time together with toddlers so that it will have an impact on mothers' attention to the growth and development of toddlers, child feeding patterns, food diversity, and macro-nutrient intake of toddlers. Research in Padang states that business women have a 1,3 times risk of experiencing malnutrition in children. Purpose: Know the differences in child feeding patterns, food diversity, and macro nutrient intake in toddlers from business women and housewife. Method: The design of this study was an observational analytic with cross sectional approach. The research was conducted on medium socioeconomic housing in Banyumas Regency. The sample are toddlers aged 12-59 months as many as 78 toddlers, taken using total sampling techniques. Data were statistically tested using independent T tests. Results: The results of study showed no differences in child feeding patterns (p = 0.605), food diversity (p = 0.767), energy intake (p = 0.483), protein intake (p = 0.806), fat intake (p = 0.787) and carbohydrate intake (p = 0.337) in toddlers from business women and housewife. Conclusions: There were no differences in child feeding patterns, food diversity, and macro nutrient intake in toddlers from business women and housewife.
Hubungan antara Asupan Asam Lemak Tidak Jenuh Ganda pada Ibu Menyusui, Kandungannya dalam ASI dan Lingkar Kepala Bayi: Studi pada Periode Awal Postpartum
Authors: Syahadah Muti'ah Mustaqimatusy , Dewi Mira , Rimbawan Rimbawan
Published: September 2021

Latar Belakang: Tercukupinya kebutuhan akan asupan asam lemak tidak jenuh ganda (polyunsaturated fatty acids, PUFA) dan status gizi ibu hamil yang optimal diketahui memiliki peran penting dalam mendukung pertumbuhan dan perkembangan otak janin dan bayi. Studi menunjukkan bahwa asupan PUFA ibu hamil di beberapa daerah di Indonesia sangat rendah dan juga masih banyak ibu hamil yang memiliki status gizi kurang. Kedua masalah gizi pada ibu hamil tersebut diduga berpengaruh terhadap pertumbuhan otak janin yang dalam penelitian ini diestimasi dengan ukuran lingkar kepala.Tujuan: Penelitian ini bertujuan menganalisis hubungan asupan PUFA ibu hamil dan status gizi pra-hamil dengan lingkar kepala bayi baru lahir.Metode: Analisis data sekunder menggunakan data hasil penelitian hibah BASF South East Asia yang telah dilakukan pada bulan April-Oktober tahun 2018 di Kota Bogor oleh tim SEAFAST CENTER IPB. Subyek merupakan ibu hamil dengan usia kehamilan trimester 3 dan merupakan kehamilan tunggal. Total terdapat 79 data ibu dan bayinya yang meliputi data asupan PUFA saat hamil, lingkar kepala bayi, karakteristik ibu, kondisi sosial-ekonomi ibu, dan IMT pra-hamil. Analisis data dilakukan menggunakan uji korelasi Spearman.Hasil: Rata-rata asupan PUFA ibu saat hamil tergolong rendah (< 80% tingkat kecukupan) serta belum memenuhi rekomendasi asupan PUFA. Asupan PUFA ibu saat hamil berhubungan positif dengan lingkar kepala bayi namun tidak signifikan (p > 0,05). Lingkar kepala bayi secara signifikan memiliki hubungan positif dengan IMT pra-hamil (p = 0,010).Kesimpulan: Lingkar kepala bayi pada penelitian ini tidak memiliki hubungan signifikan dengan asupan PUFA ibu saat hamil, namun berhubungan signifikan dengan IMT pra-hamil.
THE EFFECT OF FREE FLOAT RATIO AND PROFITABILITY ON STOCK PRICE
Authors: Sari Wiharti Arum , Rachman Arif Nugroho
Published: September 2021

The Indonesian Stock Exchange in supporting and increasing the confidence of stock investors, it is deemed necessary to apply the Free Float as an adaptation to the market capacity used in calculating the LQ45 and IDX30 Indices in 2019. Free float is the total shares whose ownership is less than 5% based on data from PT Kustodion Sentral Indonesian Securities. Changes in LQ45 and IDX30 Index Methodology were announced by the IDX in the announcement letter attached to the IDX website with IDX letter number No: Pebng-00893 / BELOPP / 11-2018 dated 23 November 2018). The discussion in this research is whether share prices can be affected by , Free float ratios, and profitability ratios which include ROE, ROA and EPS in companies listed on the LQ45 index for the period 2015-2019. The population in this research is the corporations listed on the LQ45 index. The sample collection technique used purposive sampling, with a total of 19 companies. Multiple linear regression analysis is used by researchers as an analytical tool. Multiple linear regression analysis shows that the stock price (Y) is not affected by the free float ratio (X1) and ROA (X3). ROE (X3) affects the stock price (Y) negatively, while the stock price is positively affected by EPS (X4). The results in the determination coefficient table, the adjusted R² value is 0.633, so that the dependent variable, namely the stock price, is simultaneously affected by the independent variables, namely the Free Float Ratio, ROE, ROA and EPS with a value of 63.3%, while 36.7% is affected by the variables in outside of this research.
THE EFFECT OF PROPPING ON THE PERFORMANCE OF MANUFACTURING COMPANIES IN INDONESIA
Authors: Steppani Steppani
Published: September 2021

This study aims to find empirical evidence of the impact of propping- related party transactions on company performance. The research sample was manufacturing companies listed on the IDX during 2017-2019 which were determined by purposive sampling and using the Generalized Least Square panel data regression analysis technique (cross-section weights). The results showed that propping (related party transactions related to account payables) had a positive effect on financial performance and had a negative effect on the company's market performance. Propping (related party transactions related to other payables) had a positive effect on the company's financial performance but doesn’t an affect on the company's market performance. Meanwhile, propping (related party transactions related to liabilities other than account payables) had a negative effect on financial performance but had a positive effect on the company's market performance.
Recent developments in advanced anode materials for lithium-ion batteries
Authors: Chang Hui , Wu Yu-Rong , Han Xiao , Yi Ting-Feng
Published: September 2021

The rapid expansion of electric vehicles and mobile electronic devices is the main driver for the improvement of advanced high-performance lithium-ion batteries (LIBs). The electrochemical performance of LIBs depends on the specific capacity, rate performance and cycle stability of the electrode materials. In terms of the enhancement of LIB performance, the improvement of the anode material is significant compared with the cathode material. There are still some challenges in producing an industrial anode material that is superior to commercial graphite. Based on the different electrochemical reaction mechanisms of anode materials for LIBs during charge and discharge, the advantages/disadvantages and electrochemical reaction mechanisms of intercalation-, conversion- and alloying-type anode materials are summarized in detail here. The methods and strategies for improving the electrochemical performance of different types of anode materials are described in detail. Finally, challenges for the future development of LIBs are also considered. This review offers a meaningful reference for the construction and performance optimization of anode materials for LIBs.
Modulation of Welschriesling wine volatiles through the selection of yeast and lactic acid bacteria
Authors: Suklje Katja , Čuš Franc
Published: September 2021

Welschriesling is a variety common to Central and Eastern European wine-producing countries; however, its aromatic composition remains poorly understood. Our study aims to determine the volatile profile of Welschriesling by analysing varietal thiols, esters, higher alcohols and monoterpene alcohols in commercial wines. In addition, the selection of commercial yeast starters and lactic acid bacteria (LAB) was used to modulate Welschriesling wine volatile composition. Both the selection of yeast and LAB had a significant impact on the compositional parameters of the wines. Yeast starter Uvaferm 228 (UVF228) was the most effective in terms of 3-mercaptohexan-1-ol (3MH) and 3-mercaptohexyl acetate (3MHA) production. For the ethyl esters of fatty acids (EEFAs), higher alcohol acetates (HAAs) and higher alcohols (HAs), no common inter-group behaviour could be observed based on yeast selection, however, as a group, EEFAs and HAs were highest in wines fermented with UVF228.Malolactic fermentation (MLF) significantly influenced varietal thiols, irrespective of the LAB strain used. Concentrations of 3MH significantly increased with MLF, 4-mercapto-4-methyl-pentan-2-one (4MMP) concentrations decreased, while 3MHA concentrations remained unaltered. This study showed the specific influence of yeast and LAB strain on selected volatile compounds. MLF appeared to be a promising tool to boost the presence of 3MH in wines, however, the results need further confirmation across a range of fermentation conditions and strain selections.
O ESTADO DE NATUREZA VIRTUAL E A JUSTIFICAÇÃO DAS LIBERDADES IRRESTRITAS NAS REDES SOCIAIS
Authors: Lisboa Roberto Senise , Faustino André
Published: September 2021

A popularização do uso da internet trouxe grandes desafios para o Direito, como a proteção da privacidade e a regulação do negócio eletrônico; e, principalmente a regulação das relações humanas nas redes sociais. Como o ambiente virtual é por essência difuso e de difícil controle, as pessoas, ao se utilizarem desse “espaço”, agem muitas vezes de modo diferente do “mundo físico”, pela falsa sensação de que o ambiente virtual permite tudo. Contam com o possível anonimato e a falta de empatia. Assim, as normas de convivência social são muitas vezes ignoradas, prevalecendo o interesse individual, o que se assemelha ao conceito do estado de natureza. O objetivo deste artigo é estabelecer a relação entre o conceito do estado de natureza de Thomas Hobbes com o surgimento do estado de natureza virtual, justificando-se ou não, na internet, um ambiente de liberdades irrestritas.
Frequency Converter as Node for Edge Computing of Big Data, Related to Drive Efficiency, in Industrial Internet of Things
Authors: Hetmanczyk Mariusz Piotr , Malaka Julian
Published: September 2021

The article presents a method of generating Key Performance Indicators related to electric motor energy efficiency on the basis of Big Data gathered and processed in frequency converter. The authors proved that using the proposed solution it is possible to specify the relation between the control mode of an electric drive and the control quality-energy consumption ratio in the start-up phase as well as in the steady operation with various mechanical loads. The tests were carried out on a stand equipped with two electric motors (one driving, the other used to apply the load by adjusting the parameters of the built-in brake). The measurements were made in two load cases, for motor control modes available in industrially applied frequency converters (scalar V/f, vector Voltage Flux Control without encoder, vector Voltage Flux Control with encoder, vector Current Flux Control and Vector Current Flux Control with torque control). During the experiments values of current intensities (active and output), the actual frequency value, IxT utilization factor, relative torque and the current rotational speed were measured and processed. Based on the data the level of the energy efficiency was determined for various control modes.
Genotype-Dependent Variation of Nutritional Quality-Related Traits in Quinoa Seeds
Authors: Granado-Rodríguez Sara , Vilariño-Rodríguez Susana , Maestro-Gaitán Isaac , Matías Javier , Rodríguez María José , Calvo Patricia , Cruz Verónica , Bolaños Luis , Reguera María
Published: September 2021

Exploiting the relationship between the nutritional properties of seeds and the genetic background, constitutes an essential analysis which contributes to broadening our knowledge regarding the control of the nutritional quality of seeds or any other edible plant structure. This constitutes an important aspect when aiming at improving the nutritional characteristics properties of crops, including those of Chenopodium quinoa Willd (quinoa) which is intended to be one of the main nutrient sources ensuring food security worldwide. Changes in the nutritional properties of quinoa seeds due to the influence exerted by the environment, the genotype, or their interaction, have been already described in previous works, but there is an important limitation in the analyses carried out, including the outcomes that can be translated into agronomical practices by which quality can be improved selecting the most adequate genotype. In the present study, several seed nutritional-related parameters from fifteen quinoa cultivars grown in a particular environmental context were analyzed aiming at targeting compounds that can be determinants of seed quality. Important agronomical and nutritional differences were found among cultivars such as distinct mineral or protein contents and seed viability. More importantly, our analyses revealed key correlations between seed quality-related traits in some cultivars, including those that relate yield and antioxidants or the germination rate. These results highlight the importance of considering the genotypic variation in quinoa when selecting improved quinoa varieties with the best nutritional characteristics for new cultivation environments.
Phenotype Characterization of Human Adipose-Derived Stem Cell by Flow Cytometry
Authors: Limoli Celeste , Limoli Paolo Giuseppe , Nebbioso Marcella
Published: September 2021

Background: Developing an efficient and standardized method to isolate and characterize adipose-derived stem cells (ASCs) from the stromal vascular fraction (SVF) of the adipose tissue for clinical application represents one of the major challenges in cell therapy and tissue engineering. Methods: In this study, we proposed an innovative, non-enzymatic protocol to collect clinically useful ASCs within freshly isolated SVF from adipose tissue by centrifugation of the infranatant portion of lipoaspirate and to determine the characteristic cytofluorimetric pattern, prior to in vitro culture. Results: The SVF yielded a mean of 73,32 \pm\ 10,89% cell viability evaluated with CALCEINA-FITC, i.e. cell-permeant dye. The ASCs were positive for PC7-labeled mAb anti-CD34 and negative for both PE-labeled mAb anti-CD31 and APC-labeled mAb anti-CD45. The frequency of ASCs estimated according to the panel of cell surface markers used was 51,06%\ \pm 5,26% versus the unstained ASCs subpopulation that was 0,74%\pm0,84% (P<0.0001). The ASCs events/\muL were 1602,13/\muL \pm 731,87/\muL. Conclusion: Our findings suggested that ASCs found in freshly isolated adipose SVF obtained by centrifugation of lipoaspirate can be immunophenotypically identified with a basic panel of cell surface markers. These findings aimed to provide standardization and contribute to reducing the inconsistency on reported cell surface antigens of ASC derived from the existing literature.
New Perspectives in Imaging of Uveal Melanoma
Authors: Solnik Malgorzata , Paduszynska Natalia , Czarnecka Anna M. , Synoradzki Kamil J. , Yousef Yacoub A. , Choragiewicz Tomasz , Rejdak Robert , Toro Mario Damiano , Dyndor Katarzyna , Fiedorowicz Michal
Published: September 2021

Uveal melanoma is the most common primary intraocular malignancy in adults characterized by insidious onset and poor prognosis strongly associated with tumor size and the presence of distant metastases, most commonly in the liver. Contrary to most tumor identification, biopsy followed by pathological exam is not recommended in ophthalmic oncology. Therefore, early and non-invasive diagnosis is essential to enhance patients’ chances for early treatment possibilities. We reviewed imaging modalities currently used in the diagnosis of uveal melanoma, i.e., fundus imaging, ultrasonography (US), optical coherence tomography (OCT), single-photon emission computed tomography (SPECT), positron emission tomography/computed tomography (PET/CT), magnetic resonance imaging (MRI), fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), fundus autofluorescence (FAF). The principle of imaging techniques was briefly explained, along with their role in the diagnostic process and a summary of their advantages and limitations. Further, the experimental data and the advancements in imaging modalities were searched. We described their innovations, showed current usage and research, and explained the possibilities of utilizing them to diagnose uveal melanoma and their potential application in personalized medicine such as theranostics.
Oncological Features of Intravenous Leiomyomatosis: Involvement of Mesenchymal Tumor Stem-Like Cells
Authors: Tamura Saya , Hayashi Takuma , Tokunaga Hideki , Yaegashi Nobuo , Abiko Kaoru , Konishi Ikuo
Published: September 2021

Background/Aim: Uterine leiomyoma, also known as fibroids, is the most common benign neoplasm of the female genital tract. Leiomyoma, including its subtypes, is the most common uterine tumor. The subtypes account for approximately 10% of leiomyomas. Intravenous leiomyomatosis, a uterine leiomyoma subtype, is an intravascular growth of benign smooth muscle cells, occasionally with pelvic or extrapelvic extension. Uterine leiomyosarcoma, a malignant tumor, tends to metastasize hematogenously, and distant metastasis to the lungs and liver is common. Therefore, this intravenous leiomyomatosis’ oncological features resemble those of the malignant tumor uterine leiomyosarcoma. Cancer stem cells migrate to distant organs via intravascular infiltration, leading to micrometastases. Materials and Methods: We examined the oncological properties of intravenous leiomyomatosis using molecular pathological techniques on tissue excised from patients with uterine leiomyoma. Result: CD44-positive mesenchymal tumor stem-like cells were detected in both intravenous leiomyomatosis and uterine leiomyosarcoma. The oncological nature of intravenous leiomyomatosis was found to be similar to the oncological properties of uterine leiomyosarcoma. However, in intravenous leiomyomatosis, Cyclin E and Ki-67-positive cells were rare, and no pathological findings suspected to be malignant were observed. Conclusion: It is expected that establishing a treatment method targeting cancer stem cells will lead to the treatment of malignant tumors with a low risk of recurrence and metastasis.
Inflammation and Nitro-Oxidative Stress in Current Suicidal Attempts and Current Suicidal Ideation: a Systematic Review and Meta-Analysis
Authors: Vasupanrajit Asara , Jirakran Ketsupar , Tunvirachaisakul Chavit , Solmi Marco , Maes Michael
Published: September 2021

A meta-analysis showed a significant association between activated immune-inflammatory and nitro-oxidative (IO&NS) pathways and suicide attempts (SA). There are no data whether suicidal ideation (SI) is accompanied by activated IO&NS pathways and whether there are differences between SA and SI. The current study searched PubMed, Google Scholar, and Web of Science, for articles published from inception until May 10, 2021, and systematically reviewed and meta-analyzed the association between recent SA/SI (< 3 months) and IO&NS biomarkers. We included studies which compared psychiatric patients with and without SA and SI and controls (either healthy controls or patients without SA or SI) and used meta-analysis (random-effect model with restricted maximum-likelihood) to delineate effect sizes with 95% confidence intervals (CI). Our search included 59 studies comprising 4.034 SA/SI cases and 12.377 controls. Patients with SA/SI showed activated IO&NS pathways (SMD: 0.299; CI: 0.200; 0.397) when compared to controls. The immune profiles were more strongly associated with SA than with SI, particularly when compared to healthy controls, as evidenced by activated IO&NS pathways (SMD: 0.796; CI: 0.503; 1.089), an immune-inflammatory response (SMD: 1.409; CI: 0.637; 1.462), inflammation (SMD: 1.200; CI: 0.584; 1.816), and neurotoxicity (SMD: 0.904; CI: 0.431; 1.378). The effects sizes of the IO&NS, immune-inflammatory response and inflammatory profile were significantly greater in SA than in SI. In conclusion: increased neurotoxicity due to inflammation and nitro-oxidative stress and lowered neuroprotection may explain at least in part why psychiatric patients show increased SA and SI. The IO&NS pathways are more pronounced in recent SA than in SI.
Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase
Authors: Karkali Katerina , Martin-Blanco Enrique
Published: September 2021

For developmental processes we know most of the gene networks controlling specific cell responses. We still have to determine how these networks cooperate and how signals become integrated. The JNK pathway is one of the key elements modulating cellular responses during development. Yet, we still know little on how the core components of the pathway interact with additional regulators or how this network modulates cellular responses in the whole organism in homeostasis or during tissue morphogenesis. We have performed a promoter analysis searching for potential regulatory sequences of puc and identified different specific enhancers directing gene expression in different tissues and at different developmental times. Remarkably, some of these domains respond to the JNK activity, but not all. Altogether, these analyses show that puc expression regulation is very complex and that JNK activities participate in non-previously known processes during the development of Drosophila.
Selenium-Containing Exopolysaccharides Isolated from the Culture Medium of Lentinula edodes: Structure and Biological Activity
Authors: Górska Sandra , Klimaszewska Marzenna , Podsadni Piotr , Kaleta Beata , Zagozdzon Radoslaw , Górska Sabina , Gamian Andrzej , Strączek Tomasz , Kapusta Czesław , Cieślak Marcin , Kazimierczak-Barańska Julia , Nawrot Barbara , Turło Jadwiga
Published: September 2021

In continuation of our research on the influence of selenium incorporation on the biosynthesis, structure, immunomodulatory and antioxidant activities of polysaccharides of fungal origin, we have isolated from a post-culture medium of Lentinula edodes a selenium (Se)-containing exopolysaccharide fraction composed mainly of a highly branched 1-6-α-mannoprotein of molecular weight 4.5x106 Da, with 15% protein component. The structure of this fraction resembled mannoproteins isolated from yeast and other mushroom cultures, but it was characterized by a significantly higher molecular weight. X-ray absorption fine structure spectral analysis in the near edge region (XANES) suggested that selenium in the Se-exopolysaccharide structure was present mainly at the IV oxidation state. The simulation analysis in the EXAFS region suggested the presence of two oxygen atoms in the region surrounding the selenium. On the grounds of our previous studies, we hypothesized that selenium-enriched exopolysaccharides would possess higher biological activity than the non-Se-enriched reference fraction. To perform structure-activity studies, we conducted the same tests of biological activity as for previously obtained mycelial Se-polyglucans. The Se-enriched exopolysaccharide fraction significantly enhanced cell viability when incubated with normal (human umbilical vein endothelial cells, HUVEC) cells (but this effect was absent for malignant human cervical HeLa cells) and this fraction also protected the cells from oxidative stress conditions. The results of tests on the proliferation of human peripheral blood mononuclear cells suggested a selective immunosuppressive activity, like previously tested Se-polyglucans isolated from L. edodes mycelium. The Se-exopolysaccharide fraction, in concentrations of 10-100 µg/ml, inhibited human T lymphocyte proliferation induced by mitogens, without significant effects on B lymphocytes. As with previously obtained Se-polyglucans, in the currently tested Se-polymannans the selenium content increased the biological activity. However, the activity of selenium exopolysaccharides in all tests was significantly lower than that of previously tested mycelial isolates - most likely due to a different mode of selenium binding and its higher degree of oxidation.
Biomimetic Octacalcium Phosphate Bone Has Superior Bone Regeneration Ability Than Xenogeneic or Synthetic Bone
Authors: Kim Jooseong , Kim Sukyoung , Song In-Hwan
Published: September 2021

Octacalcium phosphate (OCP) is a precursor of biological apatite crystals that has attracted attention as a possible bone substitute. On the other hand, few studies have examined this material at the experimental level due to the limitations of OCP mass production. Recently, mass production technology of OCP was developed, and the launch of OCP bone substitutes is occurring. In this study, the bone regeneration capacity of OCP products was compared with two of the most clinically used materials: heat-treated bovine bone (BHA) and sintered biphasic calcium phosphate (BCP). Twelve rabbits were used, and defects in each tibia were filled with OCP, BHA, BCP, and left unfilled as control (CON). The tibias were harvested at 4 and 12 weeks, and 15 μm slides were prepared using the diamond grinding method after being embedded in resin. Histological and histomorphometric analyses were performed to evaluate the bone regeneration ability and mechanism. The OCP showed significantly higher resorption and new bone formation in both periods analysed (p<0.05). Overall, OCP bone substitutes can enhance bone regeneration significantly by activating osteoblasts and a rapid phase transition of OCP crystals to biological apatite crystals (mineralisation), as well as providing additional space for new bone formation by rapid resorption.
Comparison of Serial and Parallel Computation on Predicting Missing Data with EM Algorithm
Authors: Nurmawati Erna , Pangaribuan Robby Hasan , Santoso Ibnu
Published: September 2021

One way to deal with the presence of missing value or incomplete data is to impute the data using EM Algorithm. The need for large and fast data processing is necessary to implement parallel computing on EM algorithm serial program. In the parallel program architecture of EM Algorithm in this study, the controller is only related to the EM module whereas the EM module itself uses matrix and vector modules intensively. Parallelization is done by using OpenMP in EM modules which results in faster compute time on parallel programs than serial programs. Parallel computing with a thread of 4 (four) increases speed up, reduces compute time, and reduces efficiency when compared to parallel computing by the number of threads 2 (two).
Characterization of Methyl Ester Sulfonate (MES) from Mahagony (Swietenia macrophylla King) with Variations in H2SO4 Concentration and Sulfonation Duration
Authors: Nurliana Laily , Kadidae La Ode , Sunarti Sunarti , Musta Rustam
Published: September 2021

Methyl ester sulfonate derived from mahogany (Swietenia macrophylla K.) oil has been characterized. The research began by synthesizing mahogany methyl ester (ME) in 4 stages: pressing, degumming, esterification, and transesterification. The next process was synthesizing methyl ester sulfonate (MES) also in four stages: sulfonation, bleaching, neutralization, and drying. The reactant for MES synthesis in this study was H2SO4 with a mole ratio of 1:6 and variations in the concentration of H2SO4 (70%, 75%, 80%, 85%, and 90%) as well as variations in the duration of sulfonation (45, 60, 75, 70, and 105 minutes) to determine the characteristics of the synthesized MES including density, acid number, and emulsion stability. The effect of the combination of treatment variations was analyzed using the two-way ANOVA test and the least significant difference (LSD) test. This research showed that MES from mahogany seed oil from a combination of variations in treatment has a density ranging from 0.91 to 0.97 g/mL where the LSD test at α = 0.05 produces three different MES density groups due to variations in the concentration of H2SO4 namely A (70 % and 75%), B (80% and 85%), and C (90%). The resulting MES acid numbers ranged from 4.69 ‒ 17.74 mgKOH/g sample with three different groups of MES acid numbers due to variations in the concentration of H2SO4, namely A (85 and 90%), B (75% and 80%), and C (70%). The stability of mahogany oil-based MES emulsion ranged from 0.000 ‒ 0.975 and two different MES emulsion stability groups were obtained due to variations in the concentration of H2SO4, namely A (80% and 85%) and B (70%, 75%, and 90%). FTIR spectrophotometer showed the presence of S=O groups at wavenumber 1172 cm-1 and S‒O groups at wavenumbers 972.12 cm-1 and 879.54 cm-1 proved that MES was successfully synthesized.
PERAN KELOMPOK SWADAYA MASYARAKAT DALAM MEWUJUDKAN PENATAAN KAMPUNG YANG BERKELANJUTAN (STUDI KASUS : KAMPUNG NGEMPLAK, JEBRES, KOTA SURAKARTA)
Authors: Kusumastuti Kusumastuti , Miladan Nur , Istanabi Tendra , Suminar Lintang , Yudana Galing , Aliyah Istijabatul , Soedwiwahjono Soedwiwahjono , Pamardhi-Utomo Rizon , Werdiningtyas Ratri , Putra Rama Permana
Published: September 2021

Sustainable Development Goals (SDG’s) memiliki tujuan untuk mengatasi permasalahan kemiskinan, kesenjangan, dan melindungi lingkungan. Konsep Green City atau Kota Hijau merupakan salah satu konsep yang dapat mewujudkan Sustainable Development Goals (SDG’s) yang berkaitan dengan isu perkotaan. Kemudian konsep Green City diturunkan menjadi Green Community sebagai topik utama yang akan direalisasikan di Kampung Ngemplak RW 29 melalui pendampingan Kelompok Swadaya Masyarakat (KSM) Kembangkoe agar dapat mewujudkan penataan Kampung Bunga yang berkelanjutan. Terbentuknya Kampung Bunga merupakan tujuan besar yang dalam prosesnya membutuhkan partisipasi bersama masyarakat dengan digerakkan oleh KSM Kembangkoe. Tujuan dari kegiatan ini adalah untuk mengetahui peran Kelompok Swadaya Masyarakat (KSM) Kembangkoe dalam usaha penataan kampung khususnya terbentuknya Kampung Bunga di Kampung Ngemplak RW 29. Metode yang digunakan menggunakan analisis deskriptif kualitatif berdasarkan hasil observasi dan wawancara selama proses pendampingan. Peran KSM Kembangkoe dapat dilihat sebagai fungsi kelembagaan, yaitu memperkuat internal dengan mengarahkan potensi sumberdaya yang dimiliki juga mencari sumberdaya eksternal yang mampu bekerja sama untuk membantu mencapai tujuan didirikannya KSM Kembangkoe.
Disparities in Opioid Overdose Death Trends by Race/Ethnicity, 2018–2019, From the HEALing Communities Study
Authors: Larochelle Marc R. , Slavova Svetla , Root Elisabeth D. , Feaster Daniel J. , Ward Patrick J. , Selk Sabrina C. , Knott Charles , Villani Jennifer , Samet Jeffrey H.
Published: September 2021

Objectives. To examine trends in opioid overdose deaths by race/ethnicity from 2018 to 2019 across 67 HEALing Communities Study (HCS) communities in Kentucky, New York, Massachusetts, and Ohio.

Methods. We used state death certificate records to calculate opioid overdose death rates per 100 000 adult residents of the 67 HCS communities for 2018 and 2019. We used Poisson regression to calculate the ratio of 2019 to 2018 rates. We compared changes by race/ethnicity by calculating a ratio of rate ratios (RRR) for each racial/ethnic group compared with non-Hispanic White individuals.

Results. Opioid overdose death rates were 38.3 and 39.5 per 100 000 for 2018 and 2019, respectively, without a significant change from 2018 to 2019 (rate ratio = 1.03; 95% confidence interval [CI] = 0.98, 1.08). We estimated a 40% increase in opioid overdose death rate for non-Hispanic Black individuals (RRR = 1.40; 95% CI = 1.22, 1.62) relative to non-Hispanic White individuals but no change among other race/ethnicities.

Conclusions. Overall opioid overdose death rates have leveled off but have increased among non-Hispanic Black individuals.

Public Health Implications. An antiracist public health approach is needed to address the crisis of opioid-related harms. (Am J Public Health. 2021;111(10):1851–1854. https://doi.org/10.2105/AJPH.2021.306431 )
Self-Reported Health Indicators in the US Army: Longitudinal Analysis From a Population Surveillance System, 2014‒2018
Authors: Kegel Jessica L. , Kazman Josh B. , Clifton Daniel R. , Deuster Patricia A. , de la Motte Sarah J.
Published: September 2021

Objectives. To describe health-related behaviors or indicators associated with overall health and well-being using the Global Assessment Tool (GAT), a health behavior and psychosocial questionnaire completed annually by US Army personnel.

Methods. We analyzed GAT responses from 2014 to 2018, consisting of 367 000 to 449 000 respondents per year. We used generalized estimating equations to predict the presence of each health behavior or indicator, aggregated by year and stratified on various demographics.

Results. Key findings included decreases from 2014 to 2018 in risky health behaviors such as hazardous drinking (7.5% decrease) and tobacco use (7.9% decrease), dietary supplement use (5.0% to 10.6% decrease, depending on type), self-reported musculoskeletal injury (5.1% decrease), and pain interference (3.6% decrease). Physical activity, sleep, and nutritional habits largely remained consistent over time.

Conclusions. In the Army, tobacco, alcohol, and risky dietary supplement usage appears to be declining, whereas lifestyle health behaviors have been stable. Whether these trends reflect responses to health education is unknown. The GAT provides useful insights into the health of the Army, which can be leveraged when developing health-related educational programs and policies.

Public Health Implications. Health behaviors that have changed less over time (e.g., nutrition, sleep) may require novel approaches compared with those that changed more (e.g., dietary supplement use, drinking). (Am J Public Health. 2021;111(11):2064–2074. https://doi.org/10.2105/AJPH.2021.306456 )
Progressive Arterial Insufficiency in a Displaced Salter-Harris Type 1 Distal Femoral Fracture
Authors: Kota Prajna B. , Terala Vamshi Krishna , Boga Srinivas , Mereddy Praveen , Atturu Gnaneswar , Gupta Prem C.
Published: September 2021

Case:

A 17-year-old male patient presented with Salter-Harris type I hyperextension injury of left distal femur with delayed development of acute limb ischemia secondary to popliteal artery injury.

Conclusion:

Popliteal artery injury associated with distal femoral physeal fracture may not be clinically obvious at the time of initial presentation. When initial pulse examination and segmental Doppler measurements are normal, it is important to perform serial examination by experienced examiners because arterial insufficiency may develop over the subsequent 48 hours. If unidentified, this can lead to significant disability and/or limb loss. This emphasizes the importance of serial monitoring along with judicious use of ankle brachial pressure index, pulse oximetry, and imaging.
Primary Lymphoma of the Distal Femur Presenting as Spontaneous Deep Vein Thrombosis and Knee Monoarthritis
Authors: Jalloh Hulaimatu B. , Ahlawat Shivani , Gross John M. , Levin Adam S. , Schaefer Richard A.
Published: September 2021

Case:

A 68-year-old man with a history of unprovoked deep vein thrombosis (DVT) presented with recurrent knee effusions after the initiation of anticoagulation. Radiographs showed soft-tissue swelling without a distinct skeletal lesion. Magnetic resonance imaging, however, showed a marrow-replacing process in the distal femur. Subsequent biopsy demonstrated B-cell lymphoma.

Conclusion:

This is a rare case of a primary lymphoma of bone mimicking synovial disease. It also highlights the fact that an unprovoked DVT may be a harbinger of an undiagnosed underlying malignancy.
Empathy Among Orthopaedic Surgery Trainees
Authors: Sabharwal Samir , Lin Carol , Weistroffer Joseph K. , LaPorte Dawn M. ,   and the Collaborative Orthopaedic Educational Research Group
Published: September 2021

Background:

It has been postulated that the process of—and stresses associated with—medical training may cause a loss of empathy among trainees. Because empathy is considered an important value for clinicians and may even be associated with better patient outcomes, we assessed the empathy of orthopaedic surgery trainees and identified factors associated with empathy.

Methods:

Between June and September 2020, an anonymous survey was distributed electronically to trainees in 23 Accreditation Council for Graduate Medical Education-accredited orthopaedic surgery residency programs via the Collaborative Orthopaedic Educational Research Group. The survey comprised the validated Short-Form 8-Item Empathy Quotient (EQ-8) questionnaire—scored on a scale of 0, least empathetic, to 16, most empathetic—and single-item measure of emotional exhaustion and depersonalization derived from the Maslach Burnout Index—scored using a frequency scale. In total, 438 of 605 (72%) trainees completed the survey. The scores were compared via one-way analysis of variance, with Bonferroni correction and Tukey post-hoc testing, α = 0.05.

Results:

The mean (±SD) EQ-8 score among respondents was 11.3 ± 3.3. Women scored significantly higher (mean, 12.2 ± 2.8) than men (mean, 11.2 ± 3.3) (p = 0.02). Mean scores were significantly higher for trainees planning on a career in academic medicine (12.0 ± 2.9) than those intending to pursue private practice (10.9 ± 3.3) or those with a military commitment (10.4 ± 3.4) (p = 0.01). An inverse relationship was found between EQ-8 scores and single-item Maslach Burnout Index measures in depersonalization and emotional exhaustion (both, p < 0.01). No significant differences were found in EQ-8 scores across postgraduate year, program location, primary training setting, intended fellowship, relationship status, or whether they reported having children.

Conclusions:

We found no association between postgraduate year and EQ-8 score. Women and those intending to pursue a career in academic medicine had significantly higher levels of empathy. A significant inverse relationship was found between burnout and empathy. Respondents with higher levels of emotional exhaustion and depersonalization had lower levels of empathy.
Patient Satisfaction, Functional Outcomes, and Implant Survivorship in Patients Undergoing Customized Cruciate-Retaining TKA
Authors: Schroeder Lennart , Pumilia Cyrus Anthony , Sarpong Nana O. , Martin Gregory
Published: September 2021

Background:

Customized total knee arthroplasty (C-TKA) systems are becoming increasingly popular in patients with end-stage knee arthritis. Manufactured with use of patient data derived from computed tomography or magnetic resonance imaging, these systems aim to restore the individual bone anatomy of the patient by providing customized fit and geometries. This retrospective study investigated implant survivorship, patient satisfaction, and functional outcomes following C-TKA with a cruciate-retaining prosthesis.

Methods:

We retrospectively reviewed data from 540 knees in 433 patients who underwent C-TKA performed by a single surgeon at a single institution. Patient demographics, surgical variables, complications, and reoperations were evaluated. Follow-up evaluations were performed via a single telephone call to assess patient satisfaction, functional outcomes according to the Knee injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS-JR) questionnaire, and implant survivorship following C-TKA. Descriptive statistics were analyzed.

Results:

At the time of C-TKA, the mean age was 71.8 years and the mean body mass index was 29.1 kg/m2. The mean follow-up was 2.8 years. Patient satisfaction was high, with 89% of C-TKA patients being either satisfied or very satisfied. The mean KOOS-JR was 82. There were 8 revisions (1.5%) at an average of 0.7 years after the index C-TKA; hence, there was an implant survivorship of 98.5%.

Conclusions:

To our knowledge, this was the largest retrospective study to date to report on patient satisfaction, functional outcomes, and implant survivorship following C-TKA. We observed a high satisfaction rate, satisfactory functional outcomes, and high implant survivorship at midterm follow-up.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Conversion Total Knee Arthroplasty
Authors: Ramamurti Pradip , Fassihi Safa C. , Stake Seth , Stadecker Monica , Whiting Zachariah , Thakkar Savyasachi C.
Published: September 2021

» Conversion total knee arthroplasty (TKA) represents a heterogeneous group of procedures and most commonly includes TKA performed after ligamentous reconstruction, periarticular open reduction and internal fixation (ORIF), high tibial osteotomy (HTO), and unicompartmental knee arthroplasty (UKA).

» Relative to patients undergoing primary TKA, patients undergoing conversion TKA often have longer operative times and higher surgical complexity, which may translate into higher postoperative complication rates.

» There is mixed evidence on implant survivorship and patient-reported outcome measures when comparing conversion TKA and primary TKA, with some studies noting no differences between the procedures and others finding decreased survivorship and outcome scores for conversion TKA.

» By gaining an improved understanding of the unique challenges facing patients undergoing conversion TKA, clinicians may better set patient expectations, make intraoperative adjustments, and guide postoperative care.
The “9.9 Super Shopping Day” Advertisement Video and Its Impact on Shopee Users on TikTok
Authors: Amrudhia Nada Farah , Nurfebiaraning Sylvie
Published: September 2021

The research objective of this study  is to find out the influence and how much the influence of Shopee’s In-Feed Native Video Ad on TikTok App toward Audience Attitude.  This study focuses on Shopee’s In-Feed Native Video advertising “9.9 Super Shopping Day” version on TikTok by involving one independent variable which is advertising (Variable X) measured using sub variables which are heard word, color, music, picture, seen word and movement. Dependent variable which is Audience Attitude (Variable Y) measured with cognitive,affective and conative aspect. The method used in this study is quantitative with data collection techniques through surveys to 400 respondents, which are followers of the @shopee_id account on the TikTok application. The results showed that the influence of the Advertising variable (X) on the Audience Attitude variable (Y) was 58,6%. While the remaining 41,4% is influenced by other factors not examined. The t test results show that the advertising variable (X) has a t value greater than the t table value because t count (23.742)> t table (1.96),then H0 is rejected and H1 is accepted. This means that Shopee’s In-Feed Native Video Ad “9.9 Super Shopping Day” version on TikTok App have an impact on audience attitude.
Communication of Opinion Leader in Commodifying Contract Marriage in Siri Marriage Village in Pasuruan
Authors: Hariyanto Didik , Difa Maulia Figo Arian
Published: September 2021

This study aims to analyze how the communication used by opinion leaders in Kalisat village gives rise to a form of commodification of contract marriage. The method in this research is using a qualitative descriptive method. Data collection was carried out by direct field observation in which researchers went directly to the field to find data in the field and carried out in-depth interview techniques that were carried out freely. The results of this study are, in the commodification process of this contract marriage there is a form of communication in which this communication is carried out face to face or face to face, namely a communication process carried out by the communicator to a communicant which is carried out directly without any help or intermediary of a media. The communication technique used by opinion leaders to invite and convince prospective brides and grooms, both men and women, is to use persuasive communication techniques. Where opinion leaders try to persuade and promise a number of advantages if they want to follow this practice, this is in accordance with the basic principles of commodification theory which changes something that initially only has use value and then turns it into something that can be sold and has a selling value in the market.
Effectiveness of Ethanolic Extract of Aloe Vera Leaves against Staphylococcus aureus
Authors: Permatasari Viki Ayu Intan , Nurjanah Mutia Hariani , Widodo Wimbuh Tri
Published: September 2021

Since long ago Indonesia used nutritious plants as traditional medicines. Various types of plants in Indonesia can be used as alternative ingredients, one of which is aloe vera. Aloe vera contains saponin and anthraquinone, so aloe vera leaves function as antiseptic and antibacteria. Staphylococcus aureus is a gram-positive coccus bacteria. This bacterium is often found as a normal germ flora in humans. Staphylococcus aureus can cause infections in humans and animals. This study aims to determine the effect of ethanolic extract of Aloe vera leaves in inhibiting Staphylococcus aureus by using maceration extract method. The concentrations used were 20%, 40%, 60%, 80% and 100% with positive control (Erytromycin) and negative control (aquades). The inhibitory zone analysis is done using the table method. Test of ethanol extract of Aloe vera leaves in inhibiting Staphylococcus aureus produced inhibition zones at concentrations of 60%, 80% and 100% with average diameter of 6.94 mm, 6.22 mm and 9.5 mm. The conclusion of this research is the ethanolic extract of Aloe vera leaves can inhibit Staphylococcus aureus in high concentrations