bluuebunny/crossref_metadata_2025 huggingface dataset:
The Presence of Anti-Angiotensin II Type-1 Receptor Antibodies Adversely Affect Kidney Graft Outcomes
Authors: Zhang Jian , Wang Mingxu , Liang Jun , Zhang Ming , Liu Xiao-Hong , Ma Le
Published: May 2017

The aim of this study was to determine whether anti-angiotensin type 1 receptor antibodies (AT1R-Abs) are related to acute rejection (AR) and kidney graft failure in renal transplantation. We searched electronic databases including MEDLINE, EMBASE, and the ISI Web of Science databases for all studies on the association between anti-angiotensin type 1 receptor antibodies and kidney allograft outcomes updated to November 2016. Reference lists from included articles were also reviewed. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were extracted or calculated using a random-effects model. The potential sources of heterogeneity and publication bias were estimated. Nine studies enrolling 1771 subjects were retrieved in the meta-analysis. AT1R-Abs showed significant associations with increased risk of AR (RR = 1.66; 95% CI, 1.23–2.09). In addition, a significant relationship was found between AT1R-Abs and kidney graft failure compared with AR (RR = 3.02; 95% CI, 1.77–4.26). The results were essentially consistent among subgroups stratified by participant characteristics. These results demonstrated that the AT1R-Abs were associated with an elevated risk of kidney allograft outcomes, especially with kidney graft failure. Large-scale studies are still required to further verify these findings.
Break in Sedentary Behavior Reduces the Risk of Noncommunicable Diseases and Cardiometabolic Risk Factors among Workers in a Petroleum Company
Authors: Jalayondeja Chutima , Jalayondeja Wattana , Mekhora Keerin , Bhuanantanondh Petcharatana , Dusadi-Isariyavong Asadang , Upiriyasakul Rujiret
Published: May 2017

Although prolonged sitting appears as a novel risk factor related to health outcomes for all ages, its association needs to be replicated in occupational conditions. This study explored the associations between sedentary behavior and four noncommunicable diseases (NCDs) as well as two cardiometabolic risk factors (CMRFs) among workers in a petroleum company, Thailand. All workers were invited to complete the online self-report questionnaire. Sedentary behavior was measured as the amount of time sitting at work, during recreation, and while commuting. Out of 3365 workers contacted, 1133 (34%) participated. Prevalence of NCDs and CMRFs was 36% and was positively associated with sedentary behavior. After adjusting for age, BMI, and exercise, the risk of NCDs and CMRFs for sedentary office work was 40% greater compared with more active field work. Those who took a break without sitting more than twice a day and commuted by walking or cycling had less risk of NCDs and CMRFs. The total duration of sedentary behavior was 10 h/day, and two-thirds of that total was workplace sitting. This was significantly associated with NCDs and CMRFs (p < 0.001). Day-and-night rotating shiftwork was negatively associated with NCDs and CMRFs (p < 0.001). Sedentary behavior should be considered a health risk among workers. Hence, to promote a healthy lifestyle and safe workplace, organizations should encourage standing activities during break and physically active commutes, and have workers avoid prolonged sitting.
The Relationship between Environmental Tobacco Smoke Exposure and Cardiovascular Disease and the Potential Modifying Effect of Diet in a Prospective Cohort among American Indians: The Strong Heart Study
Authors: Rajkumar Sarah , Fretts Amanda , Howard Barbara , Yeh Fawn , Clark Maggie
Published: May 2017

American Indians experience high rates of cardiovascular diseases (CVD). Environmental tobacco smoke (ETS) has been linked to CVD, possibly due to pro-inflammatory and oxidative stress pathways. We examined the relationship between self-reported exposure to ETS and fatal and nonfatal CVD incidence using Cox proportional hazards models among 1843 non-smoking American Indians participating in the Strong Heart Study. We also evaluated potential modifying effects of several dietary nutrients high in anti-inflammatory and anti-oxidant properties with ETS exposure on fatal and nonfatal CVD by creating interaction terms between ETS exposure and the dietary variable. Participants exposed to ETS had a higher hazard (hazard ratio: 1.22; 95% confidence interval, 1.03 to 1.44) for developing CVD compared to persons not exposed. Interaction analyses suggested stronger effects of ETS on CVD incidence among those consuming diets lower in vitamin E as compared to those consuming higher amounts, particularly on the additive scale. Additional research is recommended to clarify whether public health prevention strategies should simultaneously target reductions in ETS exposures and improvements in diets that may exceed the expected benefits of targeting these risk factors separately.
Impact of High-Resolution Topographic Mapping on Beach Morphological Analyses Based on Terrestrial LiDAR and Object-Oriented Beach Evolution
Authors: Meng Xuelian , Zhang Xukai , Silva Rodolfo , Li Chunyan , Wang Lei
Published: May 2017

This research applied terrestrial LiDAR for laboratory beach evolution experiments to quantify the impact of resolution on topographic mapping and change analyses. The multi-site registration and multi-temporal scanning processes produced high accuracy (−0.002 ± 0.003 m) topographic models in a wave tank environment. Morphological analyses based on surface change and profiles showed that models of all resolutions were capable of capturing major sediment changes in relatively smooth areas. However, higher resolution models were necessary in areas with rough surfaces and sudden elevation changes, while coarser resolution models smoothed the roughness and underestimated feature height (e.g., peaks and troughs). Decreasing resolutions from 1 to 10 cm resulted in a 2% underestimation of erosional volumes with a linear regression of y = −0.0964x + 0.4185 (R2 = 0.9651) and 3.5% overestimation of depositional volumes with a linear regression of y = 0.0664x + 0.3308 (R2 = 0.3645). However, its impact on erosion and deposition volume assessment based on object-oriented beach evolution analysis is less significant, except when fragment objects dominate the sediment changes. For Coastal Morphology Analyst (CMA), the impact of resolution is more observable through 2D object mapping in terms of object size, number, and spatial distribution. Finally, wave modeling experiments proved that resolutions caused significant changes on the behavior of the maximum wave height, the shape of the wave fronts and magnitudes of the currents.
Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy
Authors: Kosgodage Uchini , Trindade Rita , Thompson Paul , Inal Jameel , Lange Sigrun
Published: May 2017

Microvesicle (MV) release from tumour cells influences drug retention, contributing to cancer drug resistance. Strategically regulating MV release may increase drug retention within cancer cells and allow for lower doses of chemotherapeutic drugs. The contribution of exosomes to drug retention still remains unknown. Potential exosome and MV (EMV) biogenesis inhibitors, tested on human prostate cancer (PC3) cells for their capacity to inhibit EMV release, were also tested on PC3 and MCF-7 (breast cancer) cells for improving chemotherapy. Agents inhibiting EMV release most significantly, whilst maintaining cell viability, were chloramidine (Cl-amidine; 50 µM) and bisindolylmaleimide-I (10 µM). Apoptosis mediated by the chemotherapy drug 5-fluorouracil (5-FU) was significantly enhanced in PC3 cells in the presence of both these EMV inhibitors, resulting in a 62% (Cl-amidine + 5-FU) and 59% (bisindolylmaleimide-I + 5-FU) decrease in numbers of viable PC3 cells compared to 5-FU alone after 24 h. For MCF-7 cells, there were similar increased reductions of viable cells compared to 5-FU treatment alone ranging from 67% (Cl-amidine + 5-FU) to 58% (bisindolylmaleimide-I + 5-FU). Using combinatory treatment, the two EMV inhibitors further reduced the number of viable cancer cells tested. Neither inhibitor affected cell viability. Combining selected EMV inhibitors may pose as a novel strategy to enhance the efficacy of chemotherapeutic drug-mediated apoptosis.
Growth Hormone Resistance—Special Focus on Inflammatory Bowel Disease
Authors: Soendergaard Christoffer , Young Jonathan , Kopchick John
Published: May 2017

Growth hormone (GH) plays major anabolic and catabolic roles in the body and is important for regulating several aspects of growth. During an inflammatory process, cells may develop a state of GH resistance during which their response to GH stimulation is limited. In this review, we will emphasize specific mechanisms governing the formation of GH resistance in the active phase of inflammatory bowel disease. The specific molecular effects mediated through individual inflammatory mediators and processes will be highlighted to provide an overview of the transcriptional, translational and post-translational inflammation-mediated impacts on the GH receptor (GHR) along with the impacts on GH-induced intracellular signaling. We also will review GH’s effects on mucosal healing and immune cells in the context of experimental colitis, human inflammatory bowel disease and in patients with short bowel syndrome.
Diverging Concepts and Novel Perspectives in Regenerative Medicine
Authors: Muraca Maurizio , Piccoli Martina , Franzin Chiara , Tolomeo Anna , Jurga Marcin , Pozzobon Michela , Perilongo Giorgio
Published: May 2017

Regenerative medicine has rapidly evolved, due to progress in cell and molecular biology allowing the isolation, characterization, expansion, and engineering of cells as therapeutic tools. Despite past limited success in the clinical translation of several promising preclinical results, this novel field is now entering a phase of renewed confidence and productivity, marked by the commercialization of the first cell therapy products. Ongoing issues in the field include the use of pluripotent vs. somatic and of allogenic vs. autologous stem cells. Moreover, the recognition that several of the observed beneficial effects of cell therapy are not due to integration of the transplanted cells, but rather to paracrine signals released by the exogenous cells, is generating new therapeutic perspectives in the field. Somatic stem cells are outperforming embryonic and induced pluripotent stem cells in clinical applications, mainly because of their more favorable safety profile. Presently, both autologous and allogeneic somatic stem cells seem to be equally safe and effective under several different conditions. Recognition that a number of therapeutic effects of transplanted cells are mediated by paracrine signals, and that such signals can be found in extracellular vesicles isolated from culture media, opens novel therapeutic perspectives in the field of regenerative medicine.
Catastrophic Failure and Critical Scaling Laws of Fiber Bundle Material
Authors: Hao Shengwang , Yang Hang , Liang Xiangzhou
Published: May 2017

This paper presents a spring-fiber bundle model used to describe the failure process induced by energy release in heterogeneous materials. The conditions that induce catastrophic failure are determined by geometric conditions and energy equilibrium. It is revealed that the relative rates of deformation of, and damage to the fiber bundle with respect to the boundary controlling displacement ε0 exhibit universal power law behavior near the catastrophic point, with a critical exponent of −1/2. The proportion of the rate of response with respect to acceleration exhibits a linear relationship with increasing displacement in the vicinity of the catastrophic point. This allows for the prediction of catastrophic failure immediately prior to failure by extrapolating the trajectory of this relationship as it asymptotes to zero. Monte Carlo simulations are completed and these two critical scaling laws are confirmed.
Fabrication Processes to Generate Concentration Gradients in Polymer Solar Cell Active Layers
Authors: Inaba Shusei , Vohra Varun
Published: May 2017

Polymer solar cells (PSCs) are considered as one of the most promising low-cost alternatives for renewable energy production with devices now reaching power conversion efficiencies (PCEs) above the milestone value of 10%. These enhanced performances were achieved by developing new electron-donor (ED) and electron-acceptor (EA) materials as well as finding the adequate morphologies in either bulk heterojunction or sequentially deposited active layers. In particular, producing adequate vertical concentration gradients with higher concentrations of ED and EA close to the anode and cathode, respectively, results in an improved charge collection and consequently higher photovoltaic parameters such as the fill factor. In this review, we relate processes to generate active layers with ED–EA vertical concentration gradients. After summarizing the formation of such concentration gradients in single layer active layers through processes such as annealing or additives, we will verify that sequential deposition of multilayered active layers can be an efficient approach to remarkably increase the fill factor and PCE of PSCs. In fact, applying this challenging approach to fabricate inverted architecture PSCs has the potential to generate low-cost, high efficiency and stable devices, which may revolutionize worldwide energy demand and/or help develop next generation devices such as semi-transparent photovoltaic windows.
Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent
Authors: Poupard Nicolas , Badarou Pamela , Fasani Fabienne , Groult Hugo , Bridiau Nicolas , Sannier Frédéric , Bordenave-Juchereau Stéphanie , Kieda Claudine , Piot Jean-Marie , Grillon Catherine , Fruitier-Arnaudin Ingrid , Maugard Thierry
Published: May 2017

Heparanase is overexpressed by tumor cells and degrades the extracellular matrix proteoglycans through cleavage of heparan sulfates (HS), allowing pro-angiogenic factor release and thus playing a key role in tumor angiogenesis and metastasis. Here we propose new HS analogs as potent heparanase inhibitors: Heparin as a positive control, Dextran Sulfate, λ-Carrageenan, and modified forms of them obtained by depolymerization associated to glycol splitting (RD-GS). After heparanase activity assessment, 11 kDa RD-GS-λ-Carrageenan emerged as the most effective heparanase inhibitor with an IC50 of 7.32 ng/mL compared to 10.7 ng/mL for the 16 kDa unfractionated heparin. The fractionated polysaccharides were then tested in a heparanase-rich medium-based in vitro model, mimicking tumor microenvironment, to determine their effect on microvascular endothelial cells (HSkMEC) angiogenesis. As a preliminary study, we identified that under hypoxic and nutrient poor conditions, MCF-7 cancer cells released much more mature heparanase in their supernatant than in normal conditions. Then a MatrigelTM assay using HSkMEC cultured under hypoxic conditions in the presence (or not) of this heparanase-rich supernatant was realized. Adding heparanase-rich media strongly enhanced angiogenic network formation with a production of twice more pseudo-vessels than with the control. When sulfated polysaccharides were tested in this angiogenesis assay, RD-GS-λ-Carrageenan was identified as a promising anti-angiogenic agent.
The Structure and Nephroprotective Activity of Oligo-Porphyran on Glycerol-Induced Acute Renal Failure in Rats
Authors: Wang Jing , Hou Yun , Duan Delin , Zhang Quanbin
Published: May 2017

Porphyran is a sulfate galactan in the cell wall of Porphyra. Its acid hydrolysis product, oligo-porphyran (OP), was prepared and the structure studied by electrospray ionization time-of-flight mass spectrometry (ESI-TOF-MS). This oligosaccharide was mainly composed of monosulfate-oligo-galactan, disufate-oligo-galactan, trisulfate-oligo-galactan, trisulfate oligo-methyl-galactan, and 3,6-anhydrogalactose with the degree of polymerization ranging from 1 to 8. The effects of OP were investigated in the glycerol-induced acute renal failure (ARF) model. Compared with the normal group, rats from the glycerol-induced group exhibited collecting duct and medullary ascending limb dilation and casts. The OP-treated group exerted a protective effect against glycerol-induced changes. The results showed that the administration of OP markedly decreased mortality in female ARF rats. For male ARF rats, all of which survived, OP significantly decreased the blood urea nitrogen and serum creatinine levels. Ion levels in plasma and urine were significantly changed in ARF rats, whereas OP treatment almost recovered ion levels back to normal. This study showed a noticeable renal morphologic and functional protection by OP in glycerol-induced ARF rats.
Critical Condition of Dynamic Recrystallization in 35CrMo Steel
Authors: Huang Yuanchun , Wang Sanxing , Xiao Zhengbing , Liu Hui
Published: May 2017

The compression deformation behaviors of 35CrMo steel at different conditions was studied by using Gleeble-3810 thermo-simulation machine under large strain. The results indicate that the flow stress curves of 35CrMo steel is affected by strain rate and deformation temperature, showing the characteristics of dynamic recovery (DRV) and dynamic recrystallization (DRX), which is the main softening mechanism of 35CrMo steel. The activation energy (Q) and Zener–Hollomon parameter (Z parameter) expression for thermal deformation of this steel was calculated by linear regression. The inflection point on the curve of strain hardening rate and flow stress (θ-σ curve) corresponds to the beginning of DRX, and the critical strain of DRX increases with the decrease of deformation temperature and the increase of strain rate. Based on the inflection point criterion, the constitutive equation of the critical strain of DRX of 35CrMo steel was established: εc = 0.000232Z0.1673, which reflects the variation of the critical strain of DRX with the Z parameter. In addition, through metallographic observation, the rationality of the inflection point criterion in determining the critical strain of DRX of 35CrMo steel was verified, and the DRX state diagram was established.
Economic and Qualitative Determinants of the World Steel Production
Authors: Bucur Amelia , Dobrotă Gabriela , Oprean-Stan Camelia , Tănăsescu Cristina
Published: May 2017

The aim of this paper is to highlight the influence of economic and qualitative factors on steel production globally, as well in the EU, US, and China, using a dataset corresponding to the period 2000–2015. The research methods used are the study of specialist literature, problematisation, modelling, and simulation using Statistical Package for the Social Sciences (SPSS) software. The main conclusion of this paper is that, on long term, the steel production is largely influenced by the rate of real economic growth and by car production, even if in the short term the correlation is not obvious. Likewise, qualitative factors affect the steel industry in the context of current regulations on reducing carbon emissions and ensuring sustainable development. An additional aim of the present study is to define entropy in the sustainable development of steel production, as well as illustrate some of its properties and the quality management modelling of the research process in steel production.
Grade Distribution Modeling within the Bauxite Seams of the Wachangping Mine, China, Using a Multi-Step Interpolation Algorithm
Authors: Wang Shaofeng , Li Xibing
Published: May 2017

Mineral reserve estimation and mining design depend on a precise modeling of the mineralized deposit. A multi-step interpolation algorithm, including 1D biharmonic spline estimator for interpolating floor altitudes, 2D nearest neighbor, linear, natural neighbor, cubic, biharmonic spline, inverse distance weighted, simple kriging, and ordinary kriging interpolations for grade distribution on the two vertical sections at roadways, and 3D linear interpolation for grade distribution between sections, was proposed to build a 3D grade distribution model of the mineralized seam in a longwall mining panel with a U-shaped layout having two roadways at both sides. Compared to field data from exploratory boreholes, this multi-step interpolation using a natural neighbor method shows an optimal stability and a minimal difference between interpolation and field data. Using this method, the 97,576 m3 of bauxite, in which the mass fraction of Al2O3 (Wa) and the mass ratio of Al2O3 to SiO2 (Wa/s) are 61.68% and 27.72, respectively, was delimited from the 189,260 m3 mineralized deposit in the 1102 longwall mining panel in the Wachangping mine, Southwest China. The mean absolute errors, the root mean squared errors and the relative standard deviations of errors between interpolated data and exploratory grade data at six boreholes are 2.544, 2.674, and 32.37% of Wa; and 1.761, 1.974, and 67.37% of Wa/s, respectively. The proposed method can be used for characterizing the grade distribution in a mineralized seam between two roadways at both sides of a longwall mining panel.
An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC
Authors: Wen Lei , Lin Yunliang , Lv Ruimin , Yan Huijiao , Yu Jinqian , Zhao Hengqiang , Wang Xiao , Wang Daijie
Published: May 2017

In this work, flavonoid fraction from the leaves of Crataegus pinnatifida was separated into its seven main constituents using a combination of HSCCC coupled with pre-HPLC. In the first step, the total flavonoid extract was subjected to HSCCC with a two-solvent system of chloroform/methanol/water/n-butanol (4:3:2:1.5, v/v), yielding four pure compounds, namely (–)-epicatechin (1), quercetin-3-O-(2,6-di-α-l-rhamnopyranosyl)-β-d-galactopyranoside (2), 4′′-O-glucosylvitexin (3) and 2′′-O-rhamnosylvitexin (4) as well as a mixture of three further flavonoids. An extrusion mode was used to rapidly separate quercetin-3-O-(2,6-di-α-l-rhamnopyranosyl)-β-d-galactopyranoside with a big KD-value. In the second step, the mixture that resulted from HSCCC was separated by pre-HPLC, resulting in three pure compounds including: vitexin (5), hyperoside (6) and isoquercitrin (7). The purities of the isolated compounds were established to be over 98%, as determined by HPLC. The structures of these seven flavonoids were elucidated by ESI-MS and NMR spectroscopic analyses.
A Fluorescent Probe for Glycosaminoglycans Applied to the Detection of Dermatan Sulfate by a Mix-and-Read Assay
Authors: Rappold Melissa , Warttinger Ulrich , Krämer Roland
Published: May 2017

Glycosaminoglycans are complex biomolecules of great biological and medical importance. The quantification of glycosaminoglycans, in particular in complex matrices, is challenging due to their inherent structural heterogeneity. Heparin Red, a polycationic, fluorescent perylene diimide derivative, has recently emerged as a commercial probe for the convenient detection of heparins by a mix-and-read fluorescence assay. The probe also detects glycosaminoglycans with a lower negative charge density than heparin, although with lower sensitivity. We describe here the synthesis and characterization of a structurally related molecular probe with a higher positive charge of +10 (vs. +8 of Heparin Red). The superior performance of this probe is exemplified by the quantification of low dermatan sulfate concentrations in an aqueous matrix (quantification limit 1 ng/mL) and the detection of dermatan sulfate in blood plasma in a clinically relevant concentration range. The potential applications of this probe include monitoring the blood levels of dermatan sulfate after administration as an antithrombotic drug in the absence of heparin and other glycosaminoglycans.
Improving Visible Light-Absorptivity and Photoelectric Conversion Efficiency of a TiO2 Nanotube Anode Film by Sensitization with Bi2O3 Nanoparticles
Authors: Chang Menglei , Hu Huawen , Zhang Yuyuan , Chen Dongchu , Wu Liangpeng , Li Xinjun
Published: May 2017

This study presents a novel visible light-active TiO2 nanotube anode film by sensitization with Bi2O3 nanoparticles. The uniform incorporation of Bi2O3 contributes to largely enhancing the solar light absorption and photoelectric conversion efficiency of TiO2 nanotubes. Due to the energy level difference between Bi2O3 and TiO2, the built-in electric field is suggested to be formed in the Bi2O3 sensitized TiO2 hybrid, which effectively separates the photo-generated electron-hole pairs and hence improves the photocatalytic activity. It is also found that the photoelectric conversion efficiency of Bi2O3 sensitized TiO2 nanotubes is not in direct proportion with the content of the sensitizer, Bi2O3, which should be carefully controlled to realize excellent photoelectrical properties. With a narrower energy band gap relative to TiO2, the sensitizer Bi2O3 can efficiently harvest the solar energy to generate electrons and holes, while TiO2 collects and transports the charge carriers. The new-type visible light-sensitive photocatalyst presented in this paper will shed light on sensitizing many other wide-band-gap semiconductors for improving solar photocatalysis, and on understanding the visible light-driven photocatalysis through narrow-band-gap semiconductor coupling.
Transcriptomics and the Mediterranean Diet: A Systematic Review
Authors: Herrera-Marcos Luis , Lou-Bonafonte José , Arnal Carmen , Navarro María , Osada Jesús
Published: May 2017

The Mediterranean diet has been proven to be highly effective in the prevention of cardiovascular diseases and cancer and in decreasing overall mortality. Nowadays, transcriptomics is gaining particular relevance due to the existence of non-coding RNAs capable of regulating many biological processes. The present work describes a systematic review of current evidence supporting the influence of the Mediterranean diet on transcriptomes of different tissues in various experimental models. While information on regulatory RNA is very limited, they seem to contribute to the effect. Special attention has been given to the oily matrix of virgin olive oil. In this regard, monounsaturated fatty acid-rich diets prevented the expression of inflammatory genes in different tissues, an action also observed after the administration of olive oil phenolic compounds. Among these, tyrosol, hydroxytyrosol, and secoiridoids have been found to be particularly effective in cell cycle expression. Less explored terpenes, such as oleanolic acid, are important modulators of circadian clock genes. The wide range of studied tissues and organisms indicate that response to these compounds is universal and poses an important level of complexity considering the different genes expressed in each tissue and the number of different tissues in an organism.
A Low Glycaemic Index Diet Incorporating Isomaltulose Is Associated with Lower Glycaemic Response and Variability, and Promotes Fat Oxidation in Asians
Authors: Henry Christiani , Kaur Bhupinder , Quek Rina , Camps Stefan
Published: May 2017

Low glycaemic index (GI) foods minimize large blood glucose fluctuations and have been advocated to enhance fat oxidation and may contribute to weight management. We determined whether the inclusion of isomaltulose compared to sucrose in a low/high GI meal sequence can modulate the glycaemic response and substrate oxidation in an Asian population. Twenty Chinese men (body mass index (BMI): 17–28 kg/m2) followed a 24 h low GI (isomaltulose, PalatinoseTM) or high GI (sucrose) diet in a randomized double-blind, controlled cross-over design. Treatment meals included dinner (day 1), breakfast, lunch, and snack (day 2). Continuous glucose monitoring provided incremental area under the curve (iAUC) and mean amplitude of glycaemic excursion (MAGE) and 10 h indirect calorimetry (whole body calorimeter) (day 2) provided energy expenditure and substrate oxidation. Our results demonstrated that the low GI diet resulted in lower 24 h glucose iAUC (502.5 ± 231.4 vs. 872.6 ± 493.1 mmol/L; p = 0.002) and lower 24 h glycaemic variability (MAGE: 1.67 ± 0.53 vs. 2.68 ± 1.13 mmol/L; p < 0.001). Simultaneously, 10 h respiratory quotient increased more during high GI (p = 0.014) and fat oxidation was higher after low GI breakfast (p = 0.026), lunch (p < 0.001) and snack (p = 0.013). This indicates that lower GI mixed meals incorporating isomaltulose are able to acutely reduce the glycaemic response and variability and promote fat oxidation.
Comparison of Polymer Networks Synthesized by Conventional Free Radical and RAFT Copolymerization Processes in Supercritical Carbon Dioxide
Authors: Pérez-Salinas Patricia , Jaramillo-Soto Gabriel , Rosas-Aburto Alberto , Vázquez-Torres Humberto , Bernad-Bernad María , Licea-Claverie Ángel , Vivaldo-Lima Eduardo
Published: May 2017

There is a debate in the literature on whether or not polymer networks synthesized by reversible deactivation radical polymerization (RDRP) processes, such as reversible addition-fragmentation radical transfer (RAFT) copolymerization of vinyl/divinyl monomers, are less heterogeneous than those synthesized by conventional free radical copolymerization (FRP). In this contribution, the syntheses by FRP and RAFT of hydrogels based on 2-hydroxyethylene methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) in supercritical carbon dioxide (scCO2), using Krytox 157 FSL as the dispersing agent, and the properties of the materials produced, are compared. The materials were characterized by differential scanning calorimetry (DSC), swelling index (SI), infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Studies on ciprofloxacin loading and release rate from hydrogels were also carried out. The combined results show that the hydrogels synthesized by FRP and RAFT are significantly different, with apparently less heterogeneity present in the materials synthesized by RAFT copolymerization. A ratio of experimental (Mcexp) to theoretical (Mctheo) molecular weight between crosslinks was established as a quantitative tool to assess the degree of heterogeneity of a polymer network.
Review of the Current State of UAV Regulations
Authors: Stöcker Claudia , Bennett Rohan , Nex Francesco , Gerke Markus , Zevenbergen Jaap
Published: May 2017

UAVs—unmanned aerial vehicles—facilitate data acquisition at temporal and spatial scales that still remain unachievable for traditional remote sensing platforms. However, current legal frameworks that regulate UAVs present significant barriers to research and development. To highlight the importance, impact, and diversity of UAV regulations, this paper provides an exploratory investigation of UAV regulations on the global scale. For this, the methodological approach consists of a research synthesis of UAV regulations, including a thorough literature review and a comparative analysis of national regulatory frameworks. Similarities and contrasting elements in the various national UAV regulations are explored including their statuses from the perspectives of past, present, and future trends. Since the early 2000s, countries have gradually established national legal frameworks. Although all UAV regulations have one common goal—minimizing the risks to other airspace users and to both people and property on the ground—the results reveal distinct variations in all the compared variables. Furthermore, besides the clear presence of legal frameworks, market forces such as industry design standards and reliable information about UAVs as public goods are expected to shape future developments.
Compensating Unknown Time-Varying Delay in Opto-Electronic Platform Tracking Servo System
Authors: Xie Ruihong , Zhang Tao , Li Jiaquan , Dai Ming
Published: May 2017

This paper investigates the problem of compensating miss-distance delay in opto-electronic platform tracking servo system. According to the characteristic of LOS (light-of-sight) motion, we setup the Markovian process model and compensate this unknown time-varying delay by feed-forward forecasting controller based on robust H∞ control. Finally, simulation based on double closed-loop PI (Proportion Integration) control system indicates that the proposed method is effective for compensating unknown time-varying delay. Tracking experiments on the opto-electronic platform indicate that RMS (root-mean-square) error is 1.253 mrad when tracking 10° 0.2 Hz signal.
Effect of New Zealand Blackcurrant Extract on Repeated Cycling Time Trial Performance
Authors: Murphy Connor , Cook Matthew , Willems Mark
Published: May 2017

New Zealand blackcurrant (NZBC) extract increased 16.1 km cycling time trial performance. The aim of the present study was to examine the effect of NZBC extract on 2 × 4 km time trial performance. Ten male cyclists (age: 30 ± 12 years, body mass: 74 ± 9 kg, height: 179 ± 7 cm, body fat: 11 ± 3%, (V̇) ̇O2max: 55 ± 7 mL•kg−1•min−1, mean ± SD) volunteered. Participants were familiarized with the time trials. Participants consumed capsulated NZBC extract (300 mg∙day−1 CurraNZ™; containing 105 mg anthocyanin) or placebo for seven days (double blind, randomised, cross-over design, wash-out at least seven days) before 2 × 4 km time trials (10 min active self-paced recovery between trials) (SRM ergometer, SRM International, Germany). Heart rate was recorded and blood lactate sampled immediately after each trial and 8 min into recovery between the trials. Times over comparable one km distances in each 4 km time trial were similar. No effect was observed for the time to complete the first (placebo: 380 ± 28 s, NZBC: 377 ± 27 s) and second 4 km of cycling (placebo: 391 ± 32 s, NZBC: 387 ± 30 s), within both groups the second 4 km times slower by 11 ± 8 s and 11 ± 9 s for placebo and NZBC, respectively. However, the total time of the two 4 km cycling trials was 0.82% faster with NZBC extract (placebo: 771 ± 60 s, NZBC 764 ± 56 s, p = 0.034) with seven participants having faster total times. There was no effect of NZBC on heart rate and lactate values at identical time points. New Zealand blackcurrant extract seems to be beneficial in repeated short-distance cycling time trials for overall performance.
Evaluation of Third Party Logistics Providers Considering Social Sustainability
Authors: Jung Hosang
Published: May 2017

In this paper, we investigated a third-party logistics (3PL) provider evaluation problem considering social sustainability as one of the important evaluation criteria. Since the 3PL service is mainly dependent on both transport vehicles and employees, managing them from the viewpoint of social sustainability has become a critical issue. Thus, 3PL providers need to be concerned about not only the service price or quality but also issues related to social sustainability. In line with this trend, we defined the social sustainability of 3PL providers and related evaluation criteria. In addition, a fuzzy analytic hierarchy process (AHP) was used as a main evaluation framework to help decision-makers determine the relative importance of each criteria or alternative using linguistic terms. To show the feasibility of the proposed criteria and evaluation framework, we presented the illustrative example based on a real-world case. The results showed that the proposed approach could be a good alternative to conduct evaluations, and the related sensitivity analysis, considering social sustainability.
Seasonal and Interannual Fluctuation of the Microbial Soil Community in a Maize Field under Long-Term Conservation Agriculture Management
Authors: Ramírez Manuel , López-Piñeiro Antonio , Peña David , Rato Nunes José , Albarrán Ángel , Muñoz Ana , Gama José , Loures Luis
Published: May 2017

Soil’s microbiological settlement in a Zea mays parcel under long-term agricultural practices aiming to minimize the disruption of the soil’s structure, composition and natural biodiversity was analyzed by culture-dependent and culture-independent processes. Of the different processes, morphological-type differentiation of cultured microflora produced the best results and, while Polymerase Chain Reaction (PCR)-agarose electrophoresis has also provided us with reliable ones, soil PCR-DGGE (Denaturing Gradient Gel Electrophoresis) did not, which may occur because of the dependence of the method on the practice. Over a three-year period, this soil seemed very stable as its C/N ratio remained roughly constant and available for microbial growth. Because no soil overturning occurred, we were able to maintain most of the cultured microbial population whose fluctuations depended only on edaphoclimatic conditions. The number of cultured bacteria, molds, total microorganisms, and the biodiversity indices were usually lower in the driest season (fall) than in the rest of the year, except for Acinetobacter and Stenotrophomonas, which showed the opposite behavior. Coincident with the rise in temperature during the summer, the relative abundance of Gram+ bacteria increased, mostly reflecting an increase in the spore-forming bacteria Streptomyces and Bacillus. Despite these variations, the evenness index and the quantity of distinct microbiological life remained practically unaltered, recovering their maximum levels when the proper edaphoclimatic conditions were present, which indicates the long-term stability of the microbial community in this soil. The performed study put forward important insights for assessing the sustainability of maize production under long-term conservation agriculture management systems, highlighting that adequate management might prevent the degradation of soil quality, thus contributing to promote sustainable agriculture.
Influence of Organic Farming on the Potato Transcriptome
Authors: Pacifico Daniela , Onofri Chiara , Parisi Bruno , Ostano Paola , Mandolino Giuseppe
Published: May 2017

Organic agriculture sparks a lively debate on its potential health and environmental benefits. Comparative studies often investigate the response of crops to organic farming through targeted approaches and within a limited experimental work. To clarify this issue, the transcriptomic profile of a cultivar of the potato grown for two years under organic and conventional farming was compared with the profile of an experimental clone grown in the same location of Southern Italy for one year. Transcriptomic raw data were obtained through Potato Oligo Chip Initiative (POCI) microarrays and were processed using unsupervised coupling multivariate statistical analysis and bioinformatics (MapMan software). One-hundred-forty-four genes showed the same expression in both years, and 113 showed the same expression in both genotypes. Their functional characterization revealed the strong involvement of the farming system in metabolism associated with the nutritional aspects of organic tubers (e.g., phenylpropanoid, flavonoid, glycoalcaloid, asparagine, ascorbic acid). Moreover, further investigation showed that eight of 42,034 features exhibited the same trend of expression irrespective of the year and genotype, making them possible candidates as markers of traceability. This paper raises the issue regarding the choice of genotype in organic management and the relevance of assessing seasonal conditions effects when studying the effects of organic cultivation on tuber metabolism.
Objective Building Energy Performance Benchmarking Using Data Envelopment Analysis and Monte Carlo Sampling
Authors: Yoon Seong-Hwan , Park Cheol-Soo
Published: May 2017

An objective measure of building energy performance is crucial for performance assessment and rational decision making on energy retrofits and policies of existing buildings. One of the most popular measures of building energy performance benchmarking is Energy Use Intensity (EUI, kwh/m2). While EUI is simple to understand, it only represents the amount of consumed energy per unit floor area rather than the real performance of a building. In other words, it cannot take into account building services such as operation hours, comfortable environment, etc. EUI is often misinterpreted by assuming that a lower EUI for a building implies better energy performance, which may not actually be the case if many of the building services are not considered. In order to overcome this limitation, this paper presents Data Envelopment Analysis (DEA) coupled with Monte Carlo sampling. DEA is a data-driven and non-parametric performance measurement method. DEA can quantify the performance of a given building given multiple inputs and multiple outputs. In this study, two existing office buildings were selected. For energy performance benchmarking, 1000 virtual peer buildings were generated from a Monte Carlo sampling and then simulated using EnergyPlus. Based on a comparison between DEA-based and EUI-based benchmarking, it is shown that DEA is more performance-oriented, objective, and rational since DEA can take into account input (energy used to provide the services used in a building) and output (level of services provided by a building). It is shown that DEA can be an objective building energy benchmarking method, and can be used to identify low energy performance buildings.
Snapshot of Photovoltaics—March 2017
Authors: Jäger-Waldau Arnulf
Published: May 2017

Renewable energy use, especially from solar photovoltaic electricity generation, is growing at a much faster pace than the rest of the economy world-wide. The significant cost reduction of solar PV over the last decade and the zero-fuel cost volatility have increased solar PV’s attractiveness. In 2016, the newly installed solar PV power of about 75 GW was more than all the world-wide installed capacity until the end of 2011. The fact that the Paris Agreement went into force on 4 November 2016 will be another accelerating factor for the use of electricity from renewable energy sources. Apart from the electricity sector, renewable energy sources for the generation of heat and environmental friendly synthetic-fuels for the transport sector will become more and more important in the future.
Determining Factors for Economic Efficiency in the Organic Olive Oil Sector
Authors: Bernal Jurado Enrique , Mozas Moral Adoración , Fernández Uclés Domingo , Medina Viruel Miguel
Published: May 2017

Spain looms large worldwide in organic olive oil production. However, this productive potential contrasts with the low internal consumption of the product. This situation makes Spain a world leader in its export. Companies in this sector have clear deficiencies, which must be corrected to ensure their survival over time. In this context, the aim of this study is to analyse the level of efficiency, in economic terms, of organic olive oil producers and to identify the factors explaining the best organizational practices. To do so, Data Envelopment Analysis (DEA) and Qualitative Comparative Analysis (QCA) have been used. The results reveal low levels of economic efficiency and the variables determining said efficiency.
Reply to Arbenz, M. Comment on Ryffel, G.U. I Have a Dream: Organic Movements Include Gene Manipulation to Improve Sustainable Farming. Sustainability 2017, 9, 392
Authors: Ryffel Gerhart
Published: May 2017

To the Editor: Markus Arbenz and David Gould, two representatives of IFOAM—Organics International, criticize my recent editorial “I Have a Dream: Organic Movements Include Gene Manipulation to Improve Sustainable Farming” [1], as in their view I misinterpreted and misrepresented the definition of genetic engineering given in the draft version of IFOAM’s position on genetic engineering [2].[...]
Redundant Symmetry Influences Perceptual Grouping (as Measured by Rotational Linkage)
Authors: Gillam Barbara
Published: May 2017

Symmetry detection has long been a major focus of perception research. However, although symmetry is often cited as a “grouping principle”, the effect of symmetry on grouping, an important form of perceptual organization, has been little measured. In past research, we found little spatio-temporal grouping for oblique lines symmetric around a horizontal axis during ambiguous rotary motion in depth. Grouping was measured by the degree to which the ambiguous motion direction was resolved for two elements in common (rotational linkage). We hypothesized that symmetry-based grouping would be stronger if symmetry was redundant i.e., carried by elements of greater complexity. Using the rotational linkage measure, we compared grouping for horizontally symmetric simple oblique lines and for lines composed of multiple conjoined orientations and found greater grouping for the more complex symmetric lines. A control experiment ruled out possible confounding factors and also showed a grouping effect of vertically aligned endpoints. We attribute the stronger grouping effect of redundant symmetry to the fact that it has a lower probability than does simple symmetry of arising from an accidental environmental arrangement.
Service Innovations in the Healthcare Service Ecosystem: A Case Study
Authors: Ciasullo Maria , Cosimato Silvia , Pellicano Marco
Published: May 2017

In the service economy, scholars and practitioners are even more focused on the development and appliance of innovative services. The importance of service innovation is rising in many sectors and among different organizations. Several disciplines (e.g., marketing, management, operations research, etc.) deal with this innovation, a concept widely used, but with different definitions. In this paper, service innovation has been analyzed according to the Service Dominant Logic (S-D Logic) and a service ecosystem perspective. The literature still calls for a greater understanding of how a new or renewed combination of resources affects the shaping of service ecosystems. To contribute to filling this gap, this study explores the practices that different actors, enact to co-create value in novel ways; i.e., service innovation. The paper is structured as follows. In the first section, the main academic contributions on service research have been reviewed, focusing on healthcare service innovation. This is followed by the research method and discussion of the research findings. Finally, the theoretical and managerial implications have been detailed and an agenda for future research suggested. The paper offers interesting insights to develop new or renewed practices that foster the reshaping and maintaining of a healthcare service ecosystem. Some recommendations are included to support managers in the development of service innovation strategies.
Cowpox virus: What’s in a Name?
Authors: Mauldin Matthew , Antwerpen Markus , Emerson Ginny , Li Yu , Zoeller Gudrun , Carroll Darin , Meyer Hermann
Published: May 2017

Traditionally, virus taxonomy relied on phenotypic properties; however, a sequence-based virus taxonomy has become essential since the recent requirement of a species to exhibit monophyly. The species Cowpox virus has failed to meet this requirement, necessitating a reexamination of this species. Here, we report the genomic sequences of nine Cowpox viruses and, by combining them with the available data of 37 additional genomes, confirm polyphyly of Cowpox viruses and find statistical support based on genetic data for more than a dozen species. These results are discussed in light of the current International Committee on Taxonomy of Viruses species definition, as well as immediate and future implications for poxvirus taxonomic classification schemes. Data support the recognition of five monophyletic clades of Cowpox viruses as valid species.