bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the Effect of Macronutrients Combination on Blood Sugar Levels in Healthy Individuals
Authors: BASTURK Berrak , KOC OZERSON Zeynep , YUKSEL Aysun
Published: February 2021

Background: The positive effects of blood glucose levels should be demonstrated in healthy or type 2 diabetic individuals who can be recommended to consume macronutrients (protein + fat) with carbohydrates. Therefore, at the end of the research planned with the amount of carbohydrates and fats that can be consumed in a meal, we aimed to recommend the consumption of food with high protein content egg together with the carbohydrate source.
Methods: The study was carried out from Nov 2017 to Apr 2018 by looking at fasting blood glucose levels using feeding 2 different test foods on a minimum of 8 h of fasting in the Haliç University Sutluce Campus, Istanbul, Turkey. Before and after the carbohydrate and carbohydrate + protein source, blood glucose was measured from the fingertip for 3 days in 30 min, 60 min and 120 min periods. The average of 3 days was used in the analysis.
Results: Blood glucose values were compared after individuals were given carbohydrate and carbohydrate + protein source. The mean blood glucose value 60 min after the carbohydrate administration was significantly higher than the average blood glucose value 60 min after the carbohydrate + protein administration (P= 0.006).
Conclusion: A protein-containing diet positively affects the glycemia response and can recommend it. In individuals with diabetes, they should focus on the effects of proteins to achieve glycemia control.
The Cancer Risk among Physicians in Taiwan, a PopulationBased Propensity Score Matched Cohort Study
Authors: YANG Hsin-Yi , CHEN Cheng-Ren , LEE Shih-Yu , TSA Wen-Chen , HSU Yueh-Han
Published: February 2021

Background: The field of physician health is gaining increasing attention; however, most research and interventions have concentrated on factors such as job stress, mental health, and substance abuse. The risks of major cancers in physicians remain unclear. We used a propensity score-matched analysis to investigate the risk of cancer in physicians relative to the general population who had no healthcare-related professional background.
Methods: Data were obtained from the National Health Insurance system in Taiwan. The physician cohort contained 29,713 physicians, and each physician was propensity score-matched with a person from the general population.
Results: The physicians demonstrated a 0.90-fold lower risk of all-cancers (95% confidence interval [CI] = 0.83 – 0.96) when compared with the general population. Female physicians had a higher risk of cancer than male physicians (adjusted hazard ratio [HR] = 1.59; 95% CI = 1.28 – 1.96). Physicians had higher risks of prostate (HR = 1.26; 95% CI = 1.00 – 1.59) and thyroid cancers (HR = 3.16; 95% CI = 1.69 – 5.90) when compared with the general population.
Conclusion: Physicians have lower rates of overall cancer risk than the general population. Female physicians have higher cancer risks than male physicians. Male physicians have higher risks of thyroid and prostate cancer relative to the general population.
Effect of Self-Controlled Exercise on Antioxidant Activity of Red Blood Cells and Functional Recovery of Limbs in Patients with Breast Cancer after Rehabilitation
Authors: LI Feifei , LIU Wei , HUO Fei , HE Weifang , YANG Fan , WEI Jiabin , WANG Jing
Published: February 2021

Background: We aimed to investigate the effect of self-controlled exercise on the antioxidant activity of red blood cells and the recovery of limb function in patients with breast cancer after rehabilitation.
Methods: Overall 130 breast cancer patients admitted to the First Affiliated Hospital of Zhengzhou University, China from Feb 2018 to Jan 2019 were divided into intervention group and control group. The control group received perioperative care and chemotherapy, the intervention group implemented a self-controlled exercise program. Indexes were compared between the two groups before intervention, 3 months and 6 months after intervention.
Results: The activity of erythrocyte superoxide dismutase (SOD) in the intervention group was significantly increased in the first 3 months (P=0.030), and decreased from 3rd to 6th month (P=0.033). The glutathione peroxidase (GSH-Px) activity in the intervention group increased through the whole intervention period. The plasma malondialdehyde (MDA) in the intervention group was significantly decreased (P=0.029, 0.012). After intervention for 3 months and 6 months, the 6MND distances in the intervention group were significantly longer (P=0.001, 0.045). The average exercise time in the intervention group were significantly increased (P=0.004, 0.000).
Conclusion: Self-controlled exercise can effectively improve the antioxidant ability of red blood cells in patients with breast cancer, improve the mobility of shoulder joints of the affected side and increase their exercise capacity, with good sustainability. It has positive effect on postoperative rehabilitation, could be used in long-term regular clinical work.
Expression of miR-127, miR-154, and miR-183 in Medullary Thyroid Carcinoma Tumors
Authors: RAHMANI SAMANI Mahsa , ZARIF-YEGANEH Marjan , MEHRABI Atefeh , EMAMI RAZAVI Amir Nader , SHEIKHOLESLAMI Sara , HEDAYATI Mehdi
Published: February 2021

Background: Medullary thyroid cancer (MTC) accounts for 5%–10% of all thyroid cancers, but causes 13% of all thyroid cancer related deaths. MicroRNAs (miRs) have key functions in the development and progression of MTC. Altered expression of some miRs has been reported in many human cancers, including Thyroid cancer. Therefore, we aimed to analyze the expression of miR-154, miR-183 and miR-127 in MTC tumor tissues.
Methods: In this case-control study, 15 MTC Formalin-fixed, paraffin-embedded (FFPE) tissue samples and 15 adjacent normal thyroid FFPE tissues, as a control group, were collected from Taleghani, and Loghman Hakim Hospitals, Tehran, Iran since 2005 till 2015. After RNA extraction and cDNA synthesis, the expression of miR127, miR-154 and miR-183 was measured by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR).
Results: Our data showed a significant increase in the expression of miR-127 in MTC samples in comparison with the control group (P<0.05). Although miR-154 and miR-183 expression levels had increase expression in MTC tumors, this change was not statistically significant.
Conclusion: The miR-127 could be considered as a prognostic, diagnostic and therapeutic marker for the management of MTC, and it is proposed for further investigation to fully establish the role of this miRNA in MTC.
Association of a Novel KIF26B Gene Polymorphism with Susceptibility to Schizophrenia and Breast Cancer: A Case-Control Study
Authors: SARGAZI Saman , HEIDARI NIA Milad , MIRINEJAD Shekoufeh , MOUDI Mahdiyeh , JAFARI SHAHROUDI Mahdiyeh , SARAVANI Ramin , VALIAN-BOROJENI Sadegh
Published: February 2021

Background: KIF26B gene is found to play essential roles in regulating different aspects of cell proliferation and development of the nervous system. We aimed to determine if rs12407427 T/C polymorphism could affect susceptibility to schizophrenia (SZN) and breast cancer (BC), the two genetically correlated diseases.
Methods: The current case-control study was performed from Aug 2018 to Dec 2018. Briefly, 159 female pathologically confirmed BC cases referring to Alzahra Hospital, Isfahan, Iran, and 102 psychologically confirmed SZN patients (60 males and 42 females) admitted to Baharan Hospital, Zahedan, Iran, were enrolled. Using the salting-out method, genomic DNA was extracted, and variants were genotyped using allele-specific amplification refractory mutation system polymerase chain reaction (ARMS-PCR) method.
Results: The results revealed a significant association between the KIF26B rs12407427 codominant CT (P=0.001), CC (P=0.0001), dominant CT+CC, and recessive CC (P=0.001) genotypes with the risk of developing SZN. Significant correlations were also found regarding rs12407427 and BC susceptibility in different inheritance models, including over-dominant CT (P=0.026), dominant CT+CC (P=0.001), recessive CC (P=0.009), and codominant CT and CC (P=0.001) genotypes. The over-presence of the C allele was also correlated with an increased risk for SZN (P=0.0001) and BC (P=0.0001). Finally, computational analysis predicted that T/C variation in this polymorphism could change the binding sites in proteins involved in splicing.
Conclusion: rs12407427 T/C as a de novo KIF26B variant might be a novel genetic biomarker for SZN and/or BC susceptibility in a sample of the Iranian population.
Parental Occupation in Relation to Obesity in Rural-to-Urban Migrant Children in China
Authors: LI Yuqiang , YAO Liying , THOMSON JR Chepyator- , LU Jinkui
Published: February 2021

The article's abstract is not available.
Body Dissatisfaction and Associated Factors: A Study of a Group of Moroccan Adolescents’
Authors: ZAKARIA Raja , AMOR Hakima , BAALI Abdellatif
Published: February 2021

The article's abstract is not available.
Medical Waste in Traditional Medicine: A Neglected Issue
Authors: SAADATI Mohammad , REZAPOUR Ramin
Published: February 2021

The article's abstract is not available.
Fertility Diet for Women in Persian Medicine
Authors: ALIBEIGI Zeinab , TANSAZ Mojgan , ALIASL Jale , JAFARI-DEHKORDI Efat
Published: February 2021

The article's abstract is not available.
Evaluation of Associated Markers of Neonatal Pathological Jaundice Due to Bacterial Infection
Authors: LIU Yanli , SUN Xiuhua , WANG Yaqiong , XING Cuihong , LI Li , ZHOU Shiying
Published: February 2021

Background: To evaluate changes of associated markers in neonatal pathological jaundice due to bacterial infection in newborns, to provide an experimental basis for early diagnosis and treatment of neonatal pathological jaundice.
Methods: A total of 126 newborns with neonatal pathological jaundice in the Pediatrics Department of Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University from Jan 2016 to Jun 2018 were enrolled. The patients were divided into bacterial infection group (76 cases with combined bacterial infection) and non-infection group (50 cases without bacterial infection). Peripheral blood was drawn from patients, and levels of inflammatory factors, levels of indexes of liver function and levels of cardiac markers were detected. Correlation between inflammatory factors and neonatal pathological jaundice was assessed.
Results: The levels of WBC, hs-CRP and PCT in the bacterial infection group were significantly higher than those in the non-infected group (P<0.05). The level of TRF in the bacterial infection group was significantly lower than that in the non-infection group (P<0.01). In the bacterial infection group, the levels of WBC, hs-CRP, PCT, and TRF were positively correlated with the levels of CK, CKMB, LDH, and α-HBDB, respectively (all P<0.05). The TRF level after treatment was significantly higher than that before treatment (P<0.01).
Conclusion: Markers such as WBC, hs-CRP, PCT, and TRF can be used as effective indicators in diagnosis of pathological jaundice due to bacterial infection in newborns. The combined testing of WBC, hs-CRP, PCT, and TRF was helpful for early diagnosis and early clinical intervention of neonatal pathological jaundice, which can lower the risk of clinical complications.
Mental Health Problems and the Associated Family and School Factors in Adolescents: A Multilevel Analysis
Authors: Hosseinkhani Zahra , Parsaeian Mahboubeh , Hassanabadi Hamid-Reza , Khoshkchali Atefeh , Alinesaei Zahra , Nedjat Saharnaz
Published: February 2021

Objective: Mental health is one of the most important issues in adolescents’ life. Adolescents’ health is highly important, because of their role in the future. This study was conducted using multilevel analysis to investigate the risk factors at student and school levels.
Method: This was a cross sectional study for which 1740 students and 53 schools were selected between February and March 2018 in Qazvin, Iran. Multistage stratified cluster sampling was used for data collection. Mental health problems were measured by the Strengths and Difficulties Questionnaire (SDQ). Emotional symptom, conduct problem, hyperactivity, peer relationship problem, and prosocial behavior were the subscales. This study used multilevel analysis to determine the association between each of the questionnaire scales and students and schools variables.
Results: The prevalence of the mental health problems was 16.2%. Conduct problem was more prevalent than others (21.1%). Overall, the score of mental health problems was significantly lower in boys’ schools, in adolescents with physical activity, and in families with high socioeconomic status. Hyperactivity and emotional symptoms were significantly higher in girls’ schools. While prosocial behavior and peer relationship problems were significantly higher in boys’ schools. The association between variables and the scales of mental health problems was different.
Conclusion: Results indicated desirable physical activity and socioeconomic status are effective components in the adolescents’ mental health, and, mostly girls’ schools were more vulnerable than boys’ schools. Therefore, the educational authorities and health policymakers should consider this diversity to design interventional programs and pay more attention to the high-risk adolescents in different schools.
Efficacy of Gemfibrozil as an Adjunct to Sertraline in Major Depressive Disorder, A Double-Blind, Randomized, and Placebo-Controlled Clinical Trial
Authors: Zandifar Atefeh , Badrfam Rahim , Shamabadi Ahmad , Jalilevand Shakiba , Pourmirbabaei Shayan , Torkamand Farbod , Sahebolzamani Erfan , Akhondzadeh Shahin
Published: February 2021

Objective: Major depressive disorder (MDD) is predicted to be the first cause of burden of disease. The antidepressant activity of gemfibrozil has been recently considered. This study was designed to evaluate the effectiveness of gemfibrozil as a sertraline adjunct in treating patients with MDD.
Method: A total of 46 patients with MDD based on the DSM-V criteria with a minimum score of 22 on the 17-item Hamilton Rating Scale for Depression (HAM-D) were randomized to receive either 300 mg daily gemfibrozil or placebo in addition to 100 mg sertraline for 8 weeks in a randomized, double-blind placebo-controlled trial. Patients were evaluated for response to treatment using the HAM-D score at baseline and weeks 2, 4, and 8.
Results: Forty-five patients completed the study and took part in all follow-up visits. Repeated measure ANOVA with a Greenhouse-Geisser correction showed a significant difference for time×treatment interaction on within-subjects HAM-D scores [p–value= 0.026]. A significant difference was seen in time [p–value < 0.001]. The test of between-subject effects also showed a significant effect of treatment on HAM-D scores at weeks 2, 4, and 8 [p–value = 0.07]. Using KaplanMeier estimate curves, time to remission periods were significantly different between the 2 trial arms [Log-Rank p–value = 0.003].
Conclusion: Gemfibrozil is an effective adjunctive treatment in MDD and can be used to reduce depression symptoms.
Recurrent Events Model Application in Determining the Risk Factors of Bipolar Disorder Recurrence
Authors: Rezaei Mansour , Hashemi Seyed Reza , Farnia Vahid , Rahmani Sharmin
Published: February 2021

Objective: Recurrent events data is one of the most important types of survival data whose main feature is correlation between individual’s observations. The aim of this study was to analyze the time to bipolar disorder (BD) relapse and determine the related factors using recurrent events models.
Method: In this retrospective study, records of 104 BD patients with at least one relapse who were admitted for the first time (2001-2015) in Farabi hospital of Kermanshah were gathered to identify the factors influencing the time intervals between the recurrent survivals data using the Cox model with and without frailty (shared frailty), once with frailty gamma distribution and once with log-normal distribution frailty. All calculations were performed using R and SPSS software, versions 3.0.2 and 16 and the level of significance was considered at 0.05.
Results: Among the employed models, Cox model with lognormal shared frailty showed better fit for BD recurrent survival data. According to results of Cox model with lognormal frailty, 2 factors (marital status and history of veteran) were identified to affect the time intervals between relapses.
Conclusion: Because of the better fit of the models with the frailty effect on data, the correlation between the recurrent time intervals of each subject's relapse of BD was confirmed. Also, since the risk of subsequent relapses was less in married and veteran patients, marriage and emotional care supports can be considered as effective factors in reducing the risk of subsequent relapses of this disease.
Black, White and Blue: Pregnancy and Unsettled Binaries in The Masque of Blackness (1605)
Authors: Aebischer Pascale , Sparey Victoria
Published: February 2021

This article examines the construction of national and racial identities within Ben Jonson’s and Inigo Jones’s Masque of Blackness against the backdrop of King James’ investment in creating a ‘British’ union at the start of his reign. The article re-examines the blackface performance of the Queen and her ladies in the contexts of the Queen’s and Inigo Jones’ European connections, the Queen’s reputation as ‘wilful’, and her pregnant body’s ability to evoke widespread cultural beliefs about the maternal imagination’s power to determine a child’s racial make-up. We argue that the masque’s striking use of blue-face along with black and white-face reveals a deep investment in Britain’s ancient customs which stands in tension with Blackness’ showcasing of foreign bodies, technologies, and cultural reference points. By demonstrating the significance of understanding Queen Anna’s pregnancy and her ‘wilful’ personality within the context of early modern humoral theory, moreover, we develop existing discussions of the humoral theory that underpins the masque’s representation of racial identities. We suggest that the Queen’s pregnant performance in blackface, by reminding the viewer that her maternal mind could ‘will’ the racial identity of royal progeny into being, had the power to unsettle King James I’s white male nationalist supremacy in the very act of celebrating it before their new English court and its foreign guests.
Immigration and Migration Policy in the Nordic Countries
Authors: Morozova Natalia M. , Yakovleva Elena S. , Alymova Arina G.
Published: February 2021

One of the features of the modern system of international relations in terms of increasing globalization is the intensification of migration processes, the complication of the structure of migration flows. Compared to the migration crisis in Central Europe, the situation in Northern Europe looks more optimistic. Nevertheless, as the data of official statistics show, the number of arriving migrants is increasing every year, which creates an additional burden on the social institutions of society and increases tension in the societies. Another problem is the formation of ethnical enclaves on the territory of the recipient countries. For the research the Nordic region countries were selected: Denmark, Sweden, Iceland, Norway, Finland. These states are included in the ranking of the “happiest” countries in the world and attract migrants with high standards of living. But the geographic location makes the Nordic countries a little less attractive for the migrants than the Central European countries. The analysis of the measures implemented within the framework of the migration policy shows that the Northern European states have different approaches to solving the migration issue. The strictest model of migration policy is demonstrated by Denmark and Norway, the softest by Sweden and Finland. Iceland, due to its geographical location, is less exposed to migration problems and demonstrates a very loyal policy towards migrants. Scandinavian countries have long been facing a choice: on the one hand, there has been and still is a need for workforce, and on the other hand, the influx of huge numbers of migrants is a threat to the stability of the state. The migration crisis in Europe, which reached its peak in 2015, forced countries with “soft” migration laws to take measures towards tighter control over migration flows.
COVID-19 and International Labor Migration in Agriculture
Authors: Martin Philip
Published: February 2021

Two thirds of the 272 million international migrants in 2019 were employed in the destination country. Demographic and economic inequalities between countries, combined with globalization that reduced barriers to migrants, were expected to continue to increase the number of international migrant workers. Covid-19 closed many national borders to non- essential travelers, with limited exceptions. Seasonal farm workers were one of the notable exceptions, suggesting that many governments do not expect local workers to fill seasonal farm jobs despite record-high unemployment rates. For agriculture, the longer term effects of the pandemic include faster mechanization, more guest workers, and rising imports. Responses are likely to vary by commodity and be shaped by government policies. This article provides a review of the distribution and activities of the world’s 164 million international migrant workers in 2017, including the 111 million in high-income countries. The analysis focuses on the North American migrant worker and the differences between their integration in the agricultural industries. American agricultural systems are integrating in the sense that Canadian blueberries, Mexican avocados and U.S. meat trade freely, but the farm workforces in each country are increasingly Mexican.
Vietnamese Migrant Women Working Abroad: Risks and Challenges for Accessing Support Services
Authors: Vu Thi Thanh
Published: February 2021

Today Vietnam is a country with second largest number of migrant workers in Southeast Asia. Every year a great number of Vietnamese women migrate abroad by various ways for earning a living. They might experience many risks such as labor exploitation, violence and human trafficking. Basing on qualitative data collected from in-depth interviews and focus-group discussions with return women migrant workers and with provincial authority agencies in 5 provinces in Vietnam, the article reflects the risks faced by women migrant workers and their limitation of accessing help services during the time working overseas. The study also examines the ways that Vietnamese women migrate abroad. The survey proved that Vietnamese female migrant workers generally find illegal migration riskier, but easier and cheaper because it does not require a command of foreign languages, vocational skills or costly fees. Illegal migrants do not have to sign any contracts, so they can return home whenever they want. However, illegal women migrant workers experience various risks including being captured by the police, being unable to work freely and inability to access official migrant support services. The author argues that in order to increase the ability of women migrant workers to avoid risks and access support services when working abroad, it is necessary to strengthen communication channels, which would help people to know more about reliable services to send migrants to work overseas. Trainings and professional orientation workshops before departure should include more information about possible risks and the ways to find accessible support in Vietnam as well as in the destination countries.
KEYWORDS:
The Role of Labor Emigration in the Development of the Labor Market in the Sogd Region of Tajikistan
Authors: Rizokulov Turakul R. , Akramov Sharif Yu. , Abdulloeva Adolatjon T.
Published: February 2021

The article substantiates the objectivity of migration processes on a global scale, examines the trends of their development. The special approaches applied in developed countries to the issues of migration regulation in modern conditions have been studied. The consequences of market reforms on the regional labor market in the domestic economy are argued. The supply and demand for labor resources in the regional labor market are analyzed and problems are identified, in particular, low incomes and insufficiently high qualifications of workers negatively affect the development of the labor market in the regions of the Republic of Tajikistan, in particular, in the Sughd region. The authors calculated the coefficient of migration compensation for the districts of the Sughd region of the Republic of Tajikistan. The role of external migration in the development of the regional economy is characterized and conclusions are formulated about the general trends in the impact of external migration on the development of the regional labor market on the example of the Sughd region of the Republic of Tajikistan.
The evaluation of a highly specialist inpatient psychologist working with patients with high risk presentations in an acute mental health inpatient setting
Authors: Wood Lisa , Alonso Claudia , Morera Tirma , Williams Claire
Published: February 2021

Objective: To evaluate the function and impact of a highly specialist psychologist working with high risk patients in an acute mental health inpatient setting. The impact was examined on outcomes such as risk related incidents, re-admission, average length of stay, and use of
restrictive practice.
 Method: A mixed methods service evaluation of a pilot project was undertaken to examine the impact of the specialist psychologist role on these outcomes over a 17-month period. Demographic and clinical data was collected for 18 patients who were seen
by the psychologist. Routinely collected clinical data examining risk incidents, re-admission rates, average length of stay, and use of restrictive practice, were also used to evaluate outcome across the evaluation period (at baseline and six-month follow-up).
 Results: The
specialist psychologist provided input to patients' care and undertook a variety of direct and indirect work and training. Examination of descriptive routine clinical data indicated a slight reduction in risk related incidents, readmissions, and average length of stay after the introduction
of the psychologist role, however these were not statistically significant.
 Conclusion: These initial findings suggest the potential for outcome improvement, but further, more robust research is required to see if such a role can have a significant impact on outcomes.
The Shanghai Cooperation Organization and Problems of Security in Asia
Authors: Malysheva D.
Published: February 2021

The main directions of the Shanghai Cooperation Organization (SCO) activities in the sphere of regional and international security are revealed. The SCO role as a leading multilateral structure in the fight with terrorism, religious extremism and drug traffic is analyzed. The effectiveness of the SCO participation in solving the Afghan problem as well as efficiency of the SCO mediation function in border disputes is assessed. Attention is paid to the role of Russia in the context of maintaining security in Central Asia.
A STUDY OF THE PERCEPTION OF CHINESE-FILIPINOS ON BUSINESS IN METRO MANILA: ITS RELEVANCE TODAY
Authors: De Guzman Jovita Varias
Published: February 2021

This study seeks to survey and assess the preference, insights or views of the Chinese-Filipinos regarding business. It attempts to present the preferences or non-preferences of the respondents in the areas of study and its relevance to the community, to show a clearer picture of the Chinese-Filipinos in relation to business thus augmenting closer cooperation, expansion of understanding, and line of communication with Non-Chinese Filipinos. Analysis of the results may serve as an eye-opener for the public and private sector to initiate programs or actions for the creation of guidelines and policies for the awareness of those concerned.
Zaburzenia ze spektrum autyzmu i padaczka
Authors: Gurda Barbara , Malendowicz-Major Bogna , Steinborn Barbara
Published: February 2021

Zaburzenia ze spektrum autyzmu (ASD) i padaczka należą do częstych zaburzeń neurologicznych u dzieci. Częstość ich występowania szacuje się na około 1% populacji. Schorzenia te mogą występować niezależnie lub współwystępować u tej samej osoby, często z towarzyszącymi specyficznymi zaburzeniami neurorozwojowymi oraz niepełnosprawnością intelektualną. Współwystępowanie ASD i padaczki jest dobrze znane w literaturze, a występowanie padaczki w ASD szacuje się, wg różnych autorów od 2,7% do 46%. Związek między ASD i padaczką jest dwukierunkowy: u pacjentów z rozpoznaniem ASD może rozwinąć się padaczka i odwrotnie u pacjentów z napadami padaczkowymi mogą pojawić się cechy autyzmu. Podkreśla się jednak częstsze występowanie padaczki u pacjentów z ASD (13,7%) niż ASD u pacjentów z padaczką (3,4%). Istotnym czynnikiem ryzyka w obu przypadkach jest niepełnosprawność intelektualna. Ryzyko rozwoju padaczki u pacjentów z ASD wynosi wg różnych autorów od 6% do 46%. W ASD nie odnotowano dominującego typu lub zespołu padaczkowego. Jednak większość badaczy wskazuje na najczęstsze występowanie napadów ogniskowych. Ryzyko rozwoju padaczki jest większe u dzieci starszych oraz u pacjentów z niskim ilorazem inteligencji. Z drugiej strony u dzieci z rozpoznaną padaczką może również rozwinąć się ASD, wg danych z piśmiennictwa ryzyko wynosi od 3,4% do 37%, najwyższe u dzieci z wczesnym początkiem i dużą częstością napadów. Większe ryzyko rozwoju ASD istnieje również w różnych zespołach padaczkowych (zespół Westa, zespół Dravet) a także u dzieci z opóźnieniem rozwoju i niepełnosprawnością intelektualną. W wielu pracach wykazano wspólne mechanizmy patofizjologiczne obu tych schorzeń. Obecność padaczki i ASD może być zdeterminowana zmianami strukturalnymi OUN, czynnikami genetycznymi oraz zaburzeniami metabolicznymi, środowiskowymi i okołoporodowymi, które odgrywają istotną rolę w patogenezie zarówno padaczki jak i autyzmu.
Desarrollo de una base de datos para el estudio de los aditivos alimentarios en las asignaturas de química de alimentos
Authors: Martín Gómez Juan , Moyano Cañete Mª Lourdes , Zea Calero Luis , Mérida García Julieta , Pérez Serratoso María
Published: February 2021

Las TIC o tecnologías de la información y comunicación son una herramienta que permite un mayor desarrollo personal para el alumno, siendo él el protagonista en lugar del profesor. Con estas herramientas se adquieren diferentes competencias básicas necesarias para los alumnos universitarios, como son la capacidad de trabajo en equipo, la creatividad, el aprendizaje autónomo, entre otras. Además, los alumnos fueron partícipes en la evaluación de las actividades fomentando así también las competencias básicas relacionadas con la evaluación, como la reflexión.

El objetivo de este trabajo era desarrollar una base de datos sobre aditivos, incluyendo información sobre clasificación, fórmula química, grupo al que pertenece, masa molecular, toxicidad, ingesta diaria admitida. La base de datos se crea mediante la participación de alumnos en diferentes actividades de búsqueda de información. Esta base de datos estaría disponible para los alumnos y serviría a su vez al profesor para la realización de nuevas actividades a través de la plataforma Moodle de la Universidad de Córdoba.
Systematic revision and evolution of the Tithonian family Chitinoidellidae Trejo, 1975
Authors: Benzaggagh Mohamed
Published: February 2021

Several new genera and species of the family Chitinoidellidae Trejo, 1975, were erected by Pop (1997, 1998a, 1998b). Some of these taxa are justified, but others are inadequately defined, and require revision. I discuss herein the non-validity of some taxa and propose a new systematic classification and an evolutionary framework for the family Chitinoidellidae, with two subfamilies: 1) Dobeninae, which include small-sized chitinoidellids, with the genera Borziella Pop, 1997, Carpathella Pop, 1998a, Daciella Pop, 1998a (amended), Dobenilla n. gen., and Popiella Reháková, 2002, and 2) Bonetinae, which includes larger-sized chitinoidellids, with the genera Bermudeziella n. gen., Bonetilla n. gen., and Furrazolaia n. gen.. These two families are separated in time. Small species of the subfamily Dobeninae characterise the Dobeni Subzone (Ponti ammonite Zone) and disappear immediately before the occurrence of the larger specimens of the subfamily Bonetinae, which characterise the Boneti Subzone (Microcanthum p.p. ammonite Zone).
Endoscopic Resection Combined with the Cryoballoon Focal Ablation system in the Porcine Normal Esophagus: A Preclinical Study
Authors: Sunakawa Hironori , Yoda Yusuke , Takeshita Nobuyoshi , Hasegawa Hiro , Takashima Kenji , Kadota Tomohiro , Fujita Takeo , Akimoto Tetsuo , Fujii Satoshi , Yano Tomonori
Published: February 2021

Background: The Cryoballoon focal ablation system (CbFAS) for dysplastic Barrett’s esophagus is simple, time-saving and has high therapeutic efficacy. This study aimed to evaluate the technical feasibility and tissue damage with combination therapy of endoscopic resection (ER) and CbFAS in porcine models.Methods: Three pigs (A, B, and C) were included, and all ER procedures were performed by endoscopic mucosal resection using the Cap method (EMR). Combination therapy for each pig was performed as follows: (a) CbFAS was performed for a post-EMR mucosal defect for Pig A; (b) CbFAS for post-EMR scar for Pig B, and (c) EMR for post-CbFAS scar for Pig C. All pigs were euthanized at 32 days after the initial procedure, and the tissue damage was evaluated.Results: All endoscopic procedures were followed as scheduled. None of the subjects experienced anorexia, rapid weight loss, bleeding, and perforation during the observation period. They were euthanized at 32 days after the initial endoscopic procedure. On histological assessment, there was little difference between the tissue that was treated with CbFAS alone and that treated with CbFAS in combination with ER.Conclusion: Combination therapy with ER and CbFAS can be technically feasible, and its outcome was not significantly different from CbFAS alone in terms of tissue damage.
Interventricular septal curvature as an additional echocardiographic parameter for evaluating chronic thromboembolic pulmonary hypertension: A single-center retrospective study
Authors: Matsumura Akane , Shigeta Ayako , Kasai Hajime , Yokota Hajime , Terada Jiro , Yamamoto Keiko , Sugiura Toshihiko , Matsumura Takuma , Sakao Seiichiro , Tanabe Nobuhiro , Tatsumi Koichiro
Published: February 2021

Background: Noninvasive estimation of the actual systolic pulmonary artery pressure measured via right-sided heart catheterization (sPAPRHC) is important for the management of pulmonary hypertension, including chronic thromboembolic pulmonary hypertension (CTEPH). Evaluation related to the interventricular septum (IVS) is generally performed with only visual assessment and has been rarely assessed quantitatively in the field of echocardiography. Thus, this study aimed to investigate the utility of echocardiographic IVS curvature to estimate sPAPRHC in patients with CTEPH. Methods: Data of 72 patients with CTEPH were studied retrospectively. We estimated sPAPRHC using echocardiographic IVS curvature (esPAPcurv) and left ventricular eccentricity index (esPAPLVEI), and compared their ability to predict sPAPRHC with estimated sPAPRHC using tricuspid regurgitant pressure gradient (esPAPTRPG). Results: IVS curvature and LVEI were significantly correlated with sPAPRHC (r = - 0.52 and r = 0.49, respectively). Moreover, the IVS curvature was effective in estimating the sPAPRHC of patients with trivial tricuspid regurgitation (r = - 0.56) and in determining patients with sPAPRHC ≥70 mmHg with higher sensitivity (77.0%) compared to those with esPAPTRPG and esPAPLVEI. Conclusion: Our results indicate that the echocardiographic IVS curvature could be a useful additional tool for estimating sPAPRHC in CTEPH patients in whom accurate estimation of sPAPRHC using tricuspid regurgitant pressure gradient is difficult.
Simulation and Surface Topology of Activity of Pyrazoloquinoline Derivatives as Corrosion Inhibitor on the Copper Surfaces
Authors: Razavi Razieh , Zahedifar Mahboobeh , Ahmadi Sayed Ali
Published: February 2021

In the present study, interactions of pyrazolo [3,4-b]quinoline-3,5-dione derivatives on copper metal surface were considered using B3LYP/6-311 + + g(d,p) in water media and also interaction energies were simulated for all the chemical coordination’s of pyrazoloquinoline derivatives compounds. Moreover the original and novel results revealed that in all the chemical side effects and cases, pyrazoloquinoline derivatives compounds were located on the Cu metal surface. This shows that the most important desired direction is where the concentrated numbers of electron donor active atoms of inhibitor molecules interacted with the Cu metal surface atom. Furthermore the chemical Thermodynamic parameters were estimated for example: ∆G of chemical inhibitor complexes with the Cu metal surface. Density of the electron profile analysis and chemical electrostatic potential of nuclear charges in the molecule were applied to consider the nature of a number of probable interactions between Cu metal surface and inhibitors in terms of bond critical point (BCP). Finally chemical electronics parameters showed that the OH and NO2 pyrazoloquinoline derivatives have best interaction in chemical and surface media.
The different structure-function correlation as measured by OCT and Octopus perimetry cluster analysis in intracranial tumor and glaucoma patients
Authors: Li Xiaochun , Qin Jiayin , Cao Xiaoguang , Ren Zeqin , Cui Ting , Bao Yongzhen
Published: February 2021

BackgroundTo explore the correlation of visual field (VF) defect values and retinal nerve fiber layer (RNFL) thickness for the intracranial tumor and glaucoma patients. MethodsRetrospective analysis is performed for the intracranial and glaucoma patients, whose VF defect values measured with Octopus perimeter cluster analysis, and RNFL thickness and optic disk parameters measured with swept source OCT. The differences between VF and RNFL (included the data of optic disc) are calculated. The correlation between VF defect values and RNFL thickness are explored.Results43 eyes of 29 patients with the intracranial tumor and 39 eyes of 23 patients with the glaucoma are enrolled. Thickness of RNFL not only for the whole (360°), but also for the four quadrants are thinner in the glaucoma group than those of the intracranial tumor group (p<0.05). There is no significant difference of VF for those two groups. Stronger correlation for mean deviations (MD)s of VF ten clusters and RNFL thickness of OCT twelve sectors is found in the glaucoma patients, but few in the intracranial tumor patients. Logistic regression also shows the RNFL loss tending to the diagnosis of glaucoma, and the VF damage is inclined to the diagnosis of intracranial tumor.ConclusionsIntracranial tumor has a weak correlation between the RNFL thickness and Octopus VF MD, compared with that of glaucoma. OCT and Octopus VF might provide more helpful information for the antidiastole of intracranial tumor and glaucoma.
A Network Pharmacology-Based Study of the Mechanism of Renshen Baidu Powder in Treating Ulcerative Colitis
Authors: Jia Bo , Tan Xi-Yue , Liu Xing-Long , Li Xin-Yun
Published: February 2021

Ulcerative colitis (UC), one forms of chronic inflammatory bowel disease (IBD), is characterized by recurrent inflammation, and Renshen Baidu Powder (RSBDP) is often used as a traditional Chinese medicine prescription for treating of UC, but the pharmacological mechanisms remains unclear. This research aims to explore the mechanisms of RSBDP in the treatment of UC based on network pharmacology. Through multiple databases collected the compounds and targets, and constructed the network. The crossover genes enrichment analysis were performed by protein-protein interaction (PPI) construction and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Finally, 181 compounds and 266 targets were obtained. Potential candidate ingredients mainly include phytosterols, flavonoids, and coumarins, all of which have anti-inflammatory activities. GO and KEGG enrichment analysis suggested that RSBDP have anti-inflammatory and immunomodulatory effects. The effect of RSBDP on UC might be achieved by regulating the balance of cytokines (i.e., IL-6, TNF, IL-1) and the downstream mediators (i.e., STAT1, STAT3) in the immune system. And inflammation-, immune- and hypoxic-related pathways, like TNF, Toll-like receptors and HIF-1 signaling pathway. These results provide a theoretical basis for studying the effective substances of RSBDP in the treatment of UC and their mechanism of action for further research.
Analysis of Selection Signatures on the Z Chromosome of Bidirectional Selection Broiler Lines for the Aassessment of Abdominal fat Content
Authors: Wang Tao , Zhou Meng , Guo Jing , Guo Yuan-Yuan , Ding Kun , Wang Peng , Wang Zhipeng
Published: February 2021

Background: The discovery of selection signatures has enabled the identification of genomics regions under selective pressure, enhancing knowledge of evolutionary genotype-phenotypes. Sex chromosomes play an important role in species formation and evolution. Therefore, the exploration of selection signals on sex chromosomes has important biological significance.Results: In this study, we used the Cross Population Extend Haplotype Homozygosity Test (XPEHH), F-statistics (Fst) and EigenGWAS to assess selection footprints on the Z chromosome in 474 broiler chickens via Illumina chicken 60K SNP chips. SNP genotype data were downloaded from publicly available resources. We identified 35 selection regions, amongst which 1, 9 and 27 were identified by XPEHH, Fst, and EigenGWAS, respectively. Each end of the Z chromosome appeared to undergo the highest levels of selection pressure. A total of 219 candidate genes were located in 35 selection regions, some of which mediated lipogenesis, fatty acid production, fat metabolism, and fat decomposition, including FGF10, ELOVL7, and IL6ST. Using abdominal adipose tissue expression data of the chickens, 198 candidate genes were expressed with 11 differentially expressed genes (DEGs) in fat vs. lean lines identified. Amongst the DEGs, VCAN was related to fat metabolism. GO pathway enrichment analysis and QTL annotations were performed to fully characterize the selection mechanism(s) of chicken abdominal fat content. Conclusions: We have found some selection regions and candidate genes involving in fat metabolism on the Z chromosome. These findings enhance our understanding of sex chromosome selection signals.
Design of An Ultra-Thin and Broadband Absorption Materials For Middle-Temperature Applications
Authors: Jia Yanmin , Yang Zhaoning , Gao Lu , Ren Wei , Zhang Ruiduan , Zhou Qian , Li Weijun , Chen Yangyang , Zhang Yunguang , Sun Kai , Jie Ziqi
Published: February 2021

A radar absorbing material (RAM) is designed based on the magnetic ceramic and frequency selective surface (FSS). The phase composition and micromorphology were characterized, respectively. The complex permittivity and complex permeability of magnetic ceramic were tested and studied from 25 ℃ to 500 ℃ temperature. Based on the experimental and simulation results, the changes of reflection loss along with the structure parameters of RAM are analyzed at 500 ℃. The relationship of reflection loss varies with temperature are studied. The analytical results show that the absorption property of the RAM increases with the increase of temperature. An optimal absorption of RAM is obtained at 500℃. When the thickness of RAM is 1.5 mm, the reflection loss lower than -10 dB can be obtained in the frequency range from 8.2 ~ 16 GHz. More than 90% microwave energy can be consumed in the RAM which may be applied in the high temperature environment.
Real-World Data Analysis of Healthcare Resource and Cost Utilization From Non-Alcoholic Fatty Liver Disease Patients in Japan
Authors: Hasegawa Ken , Aruga Atsushi
Published: February 2021

Background: Demographic, healthcare resource utilization (HCRU), and healthcare costs of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) patients, and those progressed to liver cirrhosis (LC) and hepatocellular carcinoma (HCC) was assessed from Japan Medical Data Center (JMDC) claims database. Methods: 185,012 NAFLD or NASH patients between 1st January 2006 and 31st July 2018 were identified from JMDC database. Mean annual all-cause HCRU and costs were reported pre- and post-index date of the initial diagnosis of NAFLD/NASH, LC and HCC. Age, gender, and comorbidity influence on post-index cost was assessed with a multivariable analysis. Results: 123,379 NAFLD/NASH, 205 LC, and 96 HCC patients were selected into 3 liver severity cohorts based on the study inclusion/exclusion criteria. Majority of patients were male (70.0% to 71.7%) with comorbid hyperlipidaemia (50.2% to 61.5%), diabetes mellitus (40.0% to 60.4%), and hypertension (27.9 % to 42.7%) most prevalent across the 3 liver disease states. The mean all-cause healthcare annual cost significantly increased with liver disease severity, at ¥146,096, ¥399,425 and ¥842,875 for NAFLD/NASH, LC and HCC patients, respectively. Comorbid cardiovascular disease (CVD), following by type 2 diabetes mellitus (T2DM) had the highest influence on all-cause cost with a cost ratio of 1.77 and 1.45, respectively. Conclusions: NAFLD/NASH patients with LC or HCC have increased comorbidity burden, high HCRU, and healthcare costs, which further highlights the importance and need of timely identification and management for NAFLD and NASH patients in Japan.
Abnormal Expression of the Steroid Hormone Synthesis Pathway Associates with Cattle Ovarian Cysts
Authors: Xu Xiaoling , Bai Jiahua , Qin Yusheng , Feng Tao , Xiao Linli , Song Yuqing , Yang Ting , Liu Yan
Published: February 2021

BackgroundWhen a mature follicle fails to ovulate, ovarian cysts can develop and persist in the ovary, interfering with normal ovarian functions. However, the etiology of ovarian cysts remains poorly understood.ResultsBy enzyme-linked immunosorbent assay (ELISA) of the bovine follicle fluid from cystic follicles , we found that cystic follicles were characterized by lower oestradiol (E2), Insulin-like growth factor 1(IGF1), and insulin levels but elevated progesterone (P4) compared with preovulatory follicles (p <0.05). Further gene expression profiling of follicle walls by RNA sequencing (RNA-seq) showed that there are 356 differentially expressed genes between preovulatory follicles and corpus luteum cyst groups, and 582 differentially expressed genes between preovulatory follicles and follicular cyst groups. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis linked steroid hormone synthesis pathway to the formation of ovarian cysts, and steroidogenic acute regulatory protein (STAR), cytochrome P450, family 11, subfamily A, polypeptide 1 (CYP11A1), hydroxy-delta-5-steroid dehydrogenase, 3-beta- and steroid delta-isomerase 1 (HSD3B1), cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1), and cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) genes in the steroid hormone synthesis pathway play important roles in this process. ConclusionsAbnormal hormone profiles and expression of steroid hormone synthesis pathway genes related to the formation of ovarian cysts. The findings lay a theoretical foundation for the prevention and treatment of ovarian cysts.