bluuebunny/crossref_metadata_2025 huggingface dataset:
Dithiine-linked Metalphthalocyanine Framework with Undulated Layers for Highly Efficient and Stable H2O2 Electroproduction
Authors: Jiang Jianzhuang , zhi qianjun , Jiang Rong , Yang Xiya , Jin Yucheng , Qi Dongdong , Wang Kang
Published: July 2023

Realization of stable and industrial-level H2O2 electroproduction still faces great challenge due large partly to the easy decomposition of H2O2. Herein, a two-dimensional dithiine-linked phthalocyaninato cobalt (CoPc)-based covalent organic framework (COF), CoPc-S-COF, was afforded from the reaction of hexadecafluorophthalocyaninato cobalt (II) with 1,2,4,5-benzenetetrathiol. Introduction of the sulfur atoms with large atomic radius and two lone-pairs of electrons in the C-S-C linking unit leads to an undulated layered structure and an increased electron density of the Co center for CoPc-S-COF according to a series of experiments in combination with theoretical calculations. The former structural effect allows the exposition of more Co sites to enhance the COF catalytic performance, while the latter electronic effect activates the 2e- oxygen reduction reaction (2e- ORR) but deactivates the H2O2 decomposition capability of the same Co center, as a total result enabling CoPc-S-COF to display outstanding electrocatalytic H2O2 production performance with a remarkable H2O2 selectivity of 95% and a stable H2O2 production with a concentration of 0.48 wt% under a high current density of 125 mA cm-2 at an overpotential of ca. 190 mV for 20 h in a flow cell, representing the thus far reported best H2O2 synthesis COFs electrocatalysts.
Doğu Karadeniz Bölümü Geçici Barınma Alanlarının İrdelenmesi
Authors: ABANOZ Fatma Berfin , VURAL Nilhan
Published: July 2023

Dünyamızın doğal ekosisteminin bozulması, iklim değişikliklerinin yaşanması ve doğal kaynakların bilinçsiz tüketimi ile birlikte doğal çevre üzerinde pek çok olumsuz durum oluşmuştur. Bu olumsuzluklardan birisi olan doğal afetlerin meydana gelme sıklığı, şiddetleri ve hem doğal çevre hem de toplum üzerinde oluşturduğu hasarlar ise artmıştır. Meydana gelen bu durum sonucunda afet yönetimi ve uygulama süreçleri hem birim hem de toplum bazında yeniden planlanarak daha uygulanabilir ve kullanılabilir çalışmalar ortaya konulmuştur. Bu çalışma sisteminin bir basamağını oluşturan geçici barınma alanları, özellikle doğal afet durumu meydana geldikten sonra afetzedelerin yaşamlarını sağlıklı ve konforlu bir biçimde sürdürebilmeleri, aynı zamanda hem fiziksel hem de psikolojik olarak eski yaşam düzenlerine kısmen de olsa dönebilmeleri açısından önemlidir. Bu çalışma kapsamında Doğu Karadeniz Bölümü İl Afet ve Acil Durum (AFAD) Müdürlükleri tarafından belirlenen geçici barınma alanları; temel özellikler, ulaşım, güvenlik ve kullanıcı başlıklarında değerlendirilmiştir. Çalışmada, Doğu Karadeniz Bölümünü oluşturan Artvin, Rize, Trabzon, Bayburt, Gümüşhane, Giresun ve Ordu illerinde bulunan geçici barınma alanlarının eksikliklerinin irdelenerek bu alanların belirlenen gereksinimlere ve standartlara göre planlanması ve bu doğrultudaki araştırmalara katkıda bulunulması hedeflenmektedir.
Kuraklık ve Sıcak Hava Dalgasının Tarımsal Üretim Üzerine Etkileri
Authors: YILMAZ Gürkan
Published: July 2023

Antropojenik iklim değişikliğinin etkileri olarak, Dünya’nın birçok yerinde sıcak hava dalgalarının ve kuraklığın sıklığı ve şiddeti gün geçtikte artmaktadır. Kuraklık ve sıcak hava dalgaları genellikle birbiriyle bağlantılı afetlerdir. Uzun süreli sıcak hava dalgaları, genellikle kuraklığın oluşmasına ve/veya var olan kuraklığın şiddetinin artırmasına neden olur. Bu afet tipleri özellikle tarımsal üretimde büyük kayıp ve zararlara neden olmaktadır. Bu çalışmada; Dünya’nın farklı bölgelerinde yaşanmış kuraklık ve sıcak hava dalgası afetlerinden örnekler incelenerek, bu afet tiplerinin tarımsal üretime etkileri açıklanmaya çalışılmıştır. Çalışma kapsamında afet raporları, dergiler, kitaplar ve internet haberleri incelenmiştir. Elde edilen verilere göre; bitkisel üretim, hayvansal üretim, doğal kaynak, beşeri sermaye ve ekonominin olumsuz etkilendiği belirlenmiştir. Ekili ürünlerde, özellikle verim ve ürün kaybının yaşandığı görülmüştür. Mera alanlarında taze ot veriminde azalma ve mera alanlarının yok olması gibi durumların yaşandığı belirlenmiştir. Yem bitkilerine yönelik ekili ürünlerde ve mera alanlarında taze otlarda yaşanan kayıplar, yem fiyatlarında artışa ve yem tedarikinde ciddi sorunlara neden olmaktadır. Yem fiyatlarındaki artış ve yem temininde yaşan sorunlar ise hayvansal ürünlerde verim kaybı ve beslenen hayvan sayısının azalmasına neden olmaktadır. Ekonomik olarak ise, fiyat artışı, üretim maliyeti artışı, ihracatta azalma gibi etkilerin yaşandığı belirlenmiştir.
Synergistic antibacterial evaluation of Coriandri aetheroleum and linalool with standard antibiotics
Authors: ÖZTÜRK Gözde , GÖGER Gamze , DEMİRCİ Fatih , DEMİRCİ Betül
Published: July 2023

Within this work, it was aimed to investigate the in vitro antibacterial properties of the Pharma grade coriander (Coriandrum sativum L.) essential oil, and its combinations. The chemical composition of the essential oil was confirmed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) analyses, simultaneously. Furthermore, the potential antibacterial activity of both the essential oil, and (+)-linalool with standard compounds chloramphenicol, and ciprofloxacin were evaluated using an in vitro microdilution assay against a panel of selected pathogens, namely Acinetobacter baumannii, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Initially, the minimum inhibitory concentrations (MIC) were determined, the essential oil as well as (+)-linalool and the standard antibiotics were combined for the synergistic antibacterial activity potential, where the combination activities were expressed as fractional inhibitory concentration index values (Σ FIC). The Coriander oil was relatively more effective against B. cereus, P. aeruginosa, E. coli, A. baumannii (2500 µg/mL) compared to S. aureus (5000 µg/mL), respectively. (+)- Linalool was found as effective as the essential oil (2500-5000 µg/mL). Coriander oil and antibiotic combinations showed synergistic effects against B. cereus (∑FIC= 0.375), E. coli (∑FIC= 0.078) and S. aureus (∑FIC= 0.375). Combination with (+)-linalool, and antibiotics showed synergistic effects against B. cereus (∑FIC= 0.375), E. coli (∑FIC= 0.093), as well as against S. aureus (∑FIC= 0.375), respectively. To the best of our knowledge, this is the first time of the antimicrobial combination study of linalool, coriander oil, chloramphenicol, and ciprofloxacin. The initial findings of this work suggest further natural product and drug combination evaluations.
Novel carbazole alkaloid from Murraya koenigii (l.) Spreng
Authors: MEHREEN Arifa , KAMAL Shagufta , MUSAYEVA Sevinc , QAİSAR Muhammad , URAİNAB Sumia , ULLAH Asad
Published: July 2023

Background: The plant Murraya koenigii (L.) Spreng.native to Pakistan and India and a part of the Rutaceae family, plays a vital role in the Indian Ayurvedic medicine system. Studies have shown that this plant's bark, roots, and leaves contain many carbazole alkaloids. These alkaloids are known to have substantial therapeutic properties.
Methods:
The crushed and powdered organs of M. koenigii were extracted with several solvents (acetone, chloroform, and methanol). Then, using column chromatography, a dull brown oily substance, MK- 1 (1.05 g), was obtained with chloroform and methanol (7:3).
Result
We have successfully isolated a new carbazole alkaloid, 3-geranyl 8-hydroxy 6, 7-di methoxy 3’, 3’-dimethyl 1, 2-pyranocarbazole, from the seeds of M. koenigii. The structure was further elucidated by cross-referencing our NMR, UV, IR, and MS data with that found in the published literature.
Conclusion:
Comparing the previously published literature data clearly explained that this alkaloid is new to M. koenigii.
Antimicrobial evaluation of the Patchouli (Pogostemon cablin Benth.) leaf essential oil combination with standard antimicrobial compounds
Authors: BEŞİRİK Nazlı Şenay , GÖGER Gamze
Published: July 2023

Pogostemon cablin Benth's leaves, which belong to the Lamiaceae family, are used to make patchouli essential oil (PEO). Sesquiterpenes are the main compounds in essential oil. Antibacterial, antifungal, antiviral, antiemetic, and anti-inflammatory activities are just a few of the many pharmacological actions that are well-known. In this investigation, cefuroxime (CEF), moxifloxacin (MOX), clarithromycin (CLA), fluconazole (FLU), and terbinafine (TER) were combined with patchouli (Pogostemon cablin leaf essential oil). Gram-positive Staphylococcus aureus ATCC 6538, Gram-negative Escherichia coli ATCC 8739, and yeasts Candida albicans ATCC 10231, and C. tropicalis ATCC 750 were tested against all combinations. Drug interaction was given as fractional inhibitory concentrations (FIC) after combinations of the essential oils were tested for their minimum inhibitory concentrations (MIC).
The checkerboard method was used to assess antimicrobial interactions, Fluconazole, terbinafine, cefuroxime, and clarithromycin combined with essential oil demonstrated an "additive effect" against Candida strains together with E. coli and S. aureus.
Evaluation of Adenosine Deaminase as a Diagnostic Marker in
Tuberculous Pleural Effusion
Authors: Abdelaziz Ali O. , Hassan Rofaida N. , Elghany Elham A. Abd , Abdelfattah Rasha A. , Abdelaziz Nada A. , Hasan Ali A.
Published: July 2023

Tuberculous pleural effusion (TPE) is a common medical condition more frequently encountered
in poor countries. It is the second most common form of extra-pulmonary tuberculosis.
The diagnosis of TPE is problematic because the clinical features are non-specific, and most laboratory
tests are not diagnostic. An accurate diagnosis requires the detection of TB bacilli in the pleural
fluid or tissue sample from the pleura, which is not an easy task due to the scarcity of bacilli in the
pleural fluid and the need for invasive maneuvers to get pleural tissue for histopathological, bacteriological
or molecular confirmation for the TB bacilli.

:

Different markers in pleural fluid have been evaluated to aid in diagnosing TPE. Among those biomarkers,
Adenosine deaminase (ADA) was the most studied marker. It is an enzyme predominantly
produced by T-lymphocytes and catalyzes the conversion of adenosine to inosine and deoxyadenosine.
It is a hallmark of active cellular immunity. A high level of ADA can be found in exudative
effusion of different etiologies such as parapneumonic, tuberculous and malignant effusions.

:

Although there is still a debate over the diagnostic accuracy of ADA as a marker for TPE, many
studies recommend its use. A correct diagnosis is crucial for the start of treatment for TPE. Therefore,
it is crucial to assess the diagnostic value of adenosine deaminase in diagnosing tuberculous
pleural effusion. The ADA optimal cutoff value is still under investigation.
Mini Review on Polymer-based Nano Enable System for Targeted Delivery
of Chalcone Derivatives against Cancerous Tissues: An Effective Treatment
Approach
Authors: Mukherjee Swarupananda , Karati Dipanjan
Published: July 2023

Nanotechnology augmentation have enabled the creation of innovative colloidal preparations
that can modify the pharmacological characteristics of medications. Numerous effective applications
in the treatment of cancer have been made possible by the distinctive physicochemical and
technological characteristics of therapies based on nanomaterials. To facilitate and maximize the
interaction between cells and tissues, it is necessary to examine and modify the size, shape, charge,
and patterning of nanoscale therapeutic molecules. The flavonoids chalcones and their natural scaffolds
provide a variety of biological effects crucial for creating medicines. Plant-based anticancer
medicines represent a promising scientific and business opportunity that should be investigated. By
using traditional Chinese medicine (TCM) therapies, diseases can be avoided, and healthcare can be
enhanced. Traditional Chinese medicine is safe, straightforward, and reasonably priced. There are
numerous treatments for chronic, geriatric, and incurable diseases. Heterocyclic equivalents of chalcones
have a variety of biological properties. One of them is its anti-cancer properties, and as a result
Chalcones have drawn a huge interest in the study of malignancy. Licorice is an essential primary
ingredient in many traditional folk medicines, including Chinese and Mongolian medicine. Research
on chalcone scaffolds with strong growth-inhibitory activity in tumor cell lines was influenced
by the rising interest in this medicinal molecule, and numerous papers on these scaffolds are
now accessible. It is necessary to do a thorough examination before chalcone congeners can be developed
as a prodrug or primary chemical to treat cancer. To create a focused and efficient drug delivery
system for cancer treatment, we shall discuss chalcone derivatives and their nano-enabled
drug delivery systems in this article. It has been discussed how polymeric nanoparticles might effectively
localize in particular tumor tissues and act as drug delivery vehicles for anticancer drugs due
to their physicochemical characteristics. A promising strategy to increase the effectiveness of various
tumor treatments is the nanoencapsulation of anticancer active substances in polymeric systems.
The role of educational technology in developing the cognitive and communicative skills of university students: A Saudi Arabian case
Authors: Singh Harman Preet , Alodaynan Abdullah Mohammed Moeid
Published: July 2023

This academic research explores the transformative potential of educational technology platforms, including virtual reality, gamification, and artificial intelligence, in revolutionizing the education sector. Existing literature has indicated that educational technology holds the promise of enhancing cognitive and communicative skills among university students. However, a research gap exists, as previous studies have primarily concentrated on school children, leaving a dearth of empirical evidence in this specific context. To address this gap, our current study conducted a comprehensive survey of 305 university students in Saudi Arabia. Employing quantitative methods, we assessed the impact of educational technology on university students' cognitive and communication skills, yielding noteworthy findings. The results revealed a significant positive influence of educational technology on both cognitive (p-value 0.016) and communication skills (p-value 0.014) among university students in Saudi Arabia. This research significantly contributes to the existing literature by highlighting the importance of educational technology's accessibility and effective utilization in fostering the development of university students' cognitive and communication abilities. Furthermore, it sheds light on the implications of these findings for Saudi Arabia, a nation that has made considerable investments in educational technology and the accreditation of academic programs at its universities. Additionally, the study's outcomes suggest that educational technology can play a crucial role in facilitating the accreditation of academic programs in Saudi Arabian universities through its positive impact on university students' cognitive and communicative capabilities. This insight holds the potential to further advance the educational landscape in the country and beyond, emphasizing the need for continued integration and optimal utilization of educational technology in higher education settings.
ChatGPT as a Tool for Medical Education and Clinical Decision-Making on the Wards: Case Study (Preprint)
Authors: Skryd Anthony , Lawrence Katharine
Published: July 2023

BACKGROUND

Large language models (LLMs) are computational artificial intelligence systems with advanced natural language processing capabilities that have recently been popularized among health care students and educators due to their ability to provide real-time access to a vast amount of medical knowledge. The adoption of LLM technology into medical education and training has varied, and little empirical evidence exists to support its use in clinical teaching environments.

OBJECTIVE

The aim of the study is to identify and qualitatively evaluate potential use cases and limitations of LLM technology for real-time ward-based educational contexts.

METHODS

A brief, single-site exploratory evaluation of the publicly available ChatGPT-3.5 (OpenAI) was conducted by implementing the tool into the daily attending rounds of a general internal medicine inpatient service at a large urban academic medical center. ChatGPT was integrated into rounds via both structured and organic use, using the web-based “chatbot” style interface to interact with the LLM through conversational free-text and discrete queries. A qualitative approach using phenomenological inquiry was used to identify key insights related to the use of ChatGPT through analysis of ChatGPT conversation logs and associated shorthand notes from the clinical sessions.

RESULTS

Identified use cases for ChatGPT integration included addressing medical knowledge gaps through discrete medical knowledge inquiries, building differential diagnoses and engaging dual-process thinking, challenging medical axioms, using cognitive aids to support acute care decision-making, and improving complex care management by facilitating conversations with subspecialties. Potential additional uses included engaging in difficult conversations with patients, exploring ethical challenges and general medical ethics teaching, personal continuing medical education resources, developing ward-based teaching tools, supporting and automating clinical documentation, and supporting productivity and task management. LLM biases, misinformation, ethics, and health equity were identified as areas of concern and potential limitations to clinical and training use. A code of conduct on ethical and appropriate use was also developed to guide team usage on the wards.

CONCLUSIONS

Overall, ChatGPT offers a novel tool to enhance ward-based learning through rapid information querying, second-order content exploration, and engaged team discussion regarding generated responses. More research is needed to fully understand contexts for educational use, particularly regarding the risks and limitations of the tool in clinical settings and its impacts on trainee development.
The Effects of Industrial Park Development on Export Earning, Employment and FDI Attraction: Evidence from Ethiopia
Authors: Tesfaw Desta
Published: July 2023

This study examines the effects of industrial parks on export earnings, employment creation, and FDI attraction in Ethiopia. Furthermore, the study aims to identify the constraints and potential to achieve sustained and dynamic results expected from the industrial park development. Despite varying degrees of successes and failures, several countries have utilized industrial park and other types of special economic zones as a policy instrument for fostering economic transformation. Ethiopia is one of the African countries that have adopted industrial park development as a policy tool to enhance its economic growth and transformation. However, the effect of the industrial park policy initiative of the country is not well researched. The analysis of the study reveals that industrial parks in Ethiopia have contributed statistically significant effects on export earnings, employment creation, and FDI attraction with significant levels of p= <.001. The analysis also showed that the top five binding constraints for the effectiveness of the industrial park development are low labor productivity, domestic raw material supply constraints, weak forward and backward linkage, transport cost and logistic constraints, and institutions’ capacity constraints. On the other hand, the availability of a trainable labor force, raw material potential, preferential policies and incentives, the economic growth of the country, and the labor wage rise in China and other emerging countries are identified as the top five potentials and opportunities to achieve sustained and dynamic benefits of industrial park development in Ethiopia.
Rural Tourism Through the Community Participation and Sustainable Development: An Empirical Study from Silk Route, East Sikkim
Authors: Sarkar Dr. Sibnath
Published: July 2023

Abstract: Tourism destinations often are dependent on natural and cultural/heritage resources to form their attractions bases, which are linked to the economic vitality of local communities. Tourism industry can generate income and holistic development of a region. Rural tourism provides an economic incentive to the local people who are residing in these regions. It also adds an ethnic flavor to the consumer’s (tourist) taste. Silk Route in Sikkim is popularly known as ‘Silk Route” in Sikkim tourism map. It is one of the best rural tourist destinations of Sikkim. The silk route is very popular among the tourists. The landscape is beautiful and wonderfully thrilling. The lush greenery, panoramic view of hills and the simplicity of the indigenous inhabitants attracts the urban tourists to this place. The paper attempts an empirical presentation addressing the concept of rural tourism, which is an emerging perception on tourism introduced recently into the Indian tourism sector. This paper try to explore the potentiality as a rural tourist destination, and how such rural or Ecotourism can be an instrument to empower indigenous communities in a particular area and provide community development through economic and social benefits to the local communities for their well-being. This finding can be exemplified elsewhere as an approach on sustainable development of rural tourism through the community participation and management practiced at village level.
Study of Chemical Parameters of Himayat Sagar Lake at Rangareddy District
Authors: Siddiqua Ayesha
Published: July 2023

Abstract: Water is a single major element responsible for sustaining life on Earth. In India, water is sourced from fourteen main stream basins and countless minor basins. Furthermore, it is important to raise awareness among the public about the importance of conserving water. Chemical pollutants have been wreaking havoc on our planet's waterways, and it's time we take a stand.Take Hyderabad, for example. This city is known as the 'Limnological capital of India', and for good reason. It's home to a plethora of major and minor water bodies, many ofwhich are used as drinking water sources The study of water quality at Himayathsagar is a necessity due to its close proximity to Hyderabad city, which is growing rapidly in terms of urbanization and industrialization. In order to ensure that this important drinking water source remains safe and clean, a study of the chemical parameters of the Himayat Sagar lake in Rangareddy District was conducted. Water samples were collected and analyzed for a variety of chemical properties, such as pH, carbonates, and bicarbonates. These parameters are essential to determine the water quality and to plan forthe future management of clean water resources. The study of water quality at Himayathsagar is an important step in ensuring that this vital drinking water source remains safe and clean forgenerations to come. With the ever-growing urbanization and industrialization of Hyderabad city, it is essential that we take all necessary steps to ensure that the water quality of Himayathsagar remains at its highest level.
Post Pandemic Shift of Consumer Behavior & Cloud Kitchen
Authors: Sarbhai Ms. Archana , Khare Dr. Vivek
Published: July 2023

Abstract: The pandemic COVID-19 has significantly impacted consumer behaviour, with many people turning to online shopping and delivery services in order to avoid in-person interactions. As a result, there has been a surge in demand for food delivery services, which has led to the rise of cloud kitchens. The aim of this paper is to carry out an empirical investigation and examine elements that influence the purchase decision of generation X, Y, and Z with regards to cloud kitchens. Overall valid data of 358 responses were collected from the customers who are in practice of ordering food for home. Further data was analysed using SPSS(v26). The research provides insights that can be helpful on development of new business models, technologies, and best practices that can help restaurant owners navigate changing landscape of industry. The current findings might be useful for the restaurant owners as they may channelize efforts according to result implied in the study
Design & Manufacturing of Digital Magnet Angle Checking Gauge
Authors: Jadhav Vishal , Todkar Dr. A. S. , Patil Dr. P. J.
Published: July 2023

Abstract: This paper presents the design and analysis of semi-automated digital angle measuring system for fuel injectors. The existing system is fully mechanical and has scope to plenty of errors in operations. The gauge measures the angle between highpressure inlet and magnetic knob of fuel injector. This type of gauge is useful for Automobile industries, including manufacturing, engineering, and research, where accurate measurements of angles are essential. Design and CAE analysis have done to confirm its Strength, Performance and Stability.
The effect of reading questioning answering integrated with creative problem solving on critical thinking
Authors: Aisya Naafi , Ibrohim I. , Mahanal Susriyati , Maghfiroh Hidayati
Published: July 2023

Although the empowerment of critical thinking (CT) has become an international concern that needs to be developed in the biology learning process for high school students, there still needs to be more relevant research literature. This study aimed to compare the effectiveness of implementing reading, questioning, and answering strategies integrated with creative problem solving (RQA-CPS) with RQA, CPS, and discussion strategies. This method used the pretest-posttest non-equivalent control group design for one semester using four classes. We designed that the experimental group was taught with RQA-CPS, the control-I group was taught with RQA, the control-II group was taught with CPS, and the control-III group was taught with DP. This research involved 129 high school students in four classes with the topics Plantae, Animalia, Ecology and Environmental Change. These four topics are classified as complex material that requires CT to be able to understand in depth. The results showed that high school students' CT increased in all four classes, but the RQA-CPS group experienced the most significant increase and was significantly different compared to the other three control groups. Thus, the RQA-CPS strategy should be used in learning to improve students' CT.
Dismenore Durumuna Göre Genç Kadınların Menstrüel Profilleri ve Anksiyete Düzeyleri
Authors: BİLGİN Zümrüt
Published: July 2023

Amaç: Bu çalışma, dismenore durumlarına göre menstrüel profillerini ve anksiyete düzeylerini belirlemek amacıyla yapılmıştır.

Materyal-Metot: Tanımlayıcı ve karşılaştırmalı tipteki araştırma 04 Nisan - 31 Mayıs 2022 tarihleri arasında bir üniversitenin sağlık bilimleri fakültesinde yapılmıştır. Çalışmaya 18-45 yaş arasında 247 dismenoresi olan, 91 dismenoresi olmayan toplam 338 kadın öğrenci katılmıştır. Veriler “Tanıtıcı Bilgi Formu” ve “Sürekli Kaygı Envanteri” kullanılarak toplanmıştır.

Bulgular: Araştırmaya katılan kadın öğrencilerin yaş ortalaması 21,11±2,76’yıldır. Öğrencilerin %69,5’inin vücut kitle indeksi 18,5-24,9 aralığında olduğu, %70,1’inin kaygılı biri kişiliğe sahip olduğu, %73,1’inin dismenoresi olduğu belirlenmiştir. Çalışmada kadın öğrencilerin dismenore durumuna göre adet ağrısı yaşama sıklığı, adet ağrısının başlama zamanı, adet dönemindeki ağrının şiddeti, ailede dismenore öyküsü arasında anlamlı fark saptanmıştır (p<0.05). Dismenoresi olan ve olmayan grupların sürekli kaygı envanteri puan ortalaması arasında fark bulunmamıştır (p>0,05).

Sonuç: Bu çalışmanın sonucunda dismenoresi olan ve olmayan grupların menstrüasyon profilleri farklılık gösterirken, sürekli kaygı envanteri puan ortalaması açısından gruplar benzerlik göstermiştir. Kadınlara, menstrüel döneme özgü semptomlara yönelik danışmanlık desteği verilmesi önerilir.
Evaluation of Geriatric Psychiatric Patients in The Emergency Department
Authors: ÖZENSOY Habibe Selmin , ERDEM Ahmet Burak , GÜRÜ Meltem , TÜMER Miray
Published: July 2023

Objective: Besides the known co-morbidities, emergency department (ED) applications reveal an increasing trend due to the complications originating from the increase in the elderly population in the society. In addition, ED applications with psychiatric symptoms also continuously rise in numbers. Along these lines, in the current study, we focus on the fundamental causes associated with the ED applications of geriatric patients (> 64 years old ) with psychiatric symptoms.

Materials and Methods: The patients who applied to our ED with psychiatric symptoms between February 2019 and August 2019 and who had a psychiatry consultation were evaluated retrospectively. The demographic data, co-morbidities, known psychiatric diseases, admission symptoms, and outcome diagnoses of the patients were recorded. The results were evaluated statistically.

Results: A total of 43.2 % of male patients who were over the age of 65, and 43.3 % of female patients were admitted to our ED with the most common complaint of anxiety. No significant relations were detected between suicide attempts and the presence of psychiatric disease in elderly patients (p = 0.93). Delirium was the most common diagnosis in the geriatric population without any known psychiatric disease (n = 10). All patients were diagnosed with depression, delirium, and dementia, respectively, after the emergency psychiatric evaluation.

Conclusion: Healthcare costs and morbidity-mortality rates of the senior patients with psychiatric symptoms can be significantly diminished upon the diagnosis of depression, delirium, and dementia via psychiatric examinations.
Drug-Excipient Compatibility Studies In Binary Mixtures of Tadalafil by Using DSC, TGA and FTIR
Authors: DOĞANTÜRK Mahmut , SEÇİLMİŞ CANBAY Hale
Published: July 2023

Objective: During drug preformulation studies, thermal analysis and spectroscopic techniques are used to detect physical or chemical incompatibilities between the active compound and the excipients in the formulation, and to demonstrate the safety and/or efficacy of the final product. It has revolutionized erectile dysfunction with the development of a selective cyclic guanosine monophosphate-specific PDE-5 inhibitors. Tadalafil is one of these inhibitors. Excipients are included in dosage forms to assist in manufacture, absorption or application. Although considered to be pharmacologically inert, the drug active compound may impair effectiveness.

Material and Method: DSC, TGA, and FTIR, were used in the work. Ascorbic acid, butylated hydroxyanisole, calcium phosphate dibasic, cellulose, magnesium stearate, mannitol, sodium carboxymethyl cellulose, sucrose, talc, starch, primojel, and citric acid exhibit interaction with Tadalafil. Binary mixtures of drug:excipient have been analyzed.

Results: Based on spectroscopic and thermal results; Tadalafil is incompatible with magnesium stearate, mannitol, sucrose, and ascorbic acid.

Conclusion: Studies to investigate drug-excipient compatibility are an important step in drug development studies. Thermal and spectroscopic techniques are widely used in such studies.
An exploratory study of police impersonation crimes: Confrontational offenders and offenses
Authors:   University of Colorado Denver, Denver, United States, Al Ghareeb Shahla , Dodge Mary ,   University of Colorado Denver, Denver, United States
Published: July 2023

This research focuses on confrontational police impersonation crimes, which include the false impersonation of federal agents, official and state personnel, and local or national law enforcement. Extant research that examines police impersonators suggests that the extent of this crime is more widespread than commonly believed and is rarely researched. This study offers a broader perspective compared to previous research and examines different types of fraudulent acts. Data from identity fraud incidents reported in the news media were collected using the Google Alert system. News articles from February 2016 through May 2020 were coded employing content and thematic analyses. The results indicate that police impersonation crimes vary in type and motive. Finally, the discussion offers suggestions for future research, policies, and regulations.
Características metodológicas del análisis de información en la inteligencia policial de Colombia
Authors:   Policía Nacional de Colombia, Bogotá, Colombia, Villamizar Moreno Artur Oswaldo , Pedraza Uribe Luisa Fernanda ,   Policía Nacional de Colombia, Bogotá, Colombia
Published: July 2023

La inteligencia policial en Colombia ejecuta un ciclo con las actividades de planeación, recolección, tratamiento, análisis, comunicación y evaluación para asesorar la toma de decisiones del mando institucional y del Gobierno Nacional. El artículo discute las características metodológicas del análisis de información de inteligencia, a partir de un diseño de caso con alcance descriptivo y enfoque cualitativo en tres fases. La primera, recopila veintiséis casos de análisis que en la segunda fase se sometieron a un proceso de revisión y validación de expertos para seleccionar tres casos tipo exitosos; en la tercera fase se construyeron mapas cognitivos con énfasis en los rasgos representativos y susceptibles de réplica. Los resultados muestran que no existe claridad de los criterios decisionales empleados en la formulación de alternativas de solución, el uso y articulación de técnicas de análisis es restringido y se presenta confusión entre métodos de análisis y de inteligencia policial. Se concluye que la inteligencia policial cuenta con casos exitosos de análisis; sin embargo, los razonamientos de los analistas se basan en la experiencia, de modo que el uso de técnicas e instrumentos es limitado. Se recomienda un diálogo de saberes científicos y empíricos para elevar los estándares de los informes de inteligencia.
Formação do pesquisador em contexto de pandemia
Authors: Prazeres Elielson Farias dos , Silva João Batista do Carmo , Silva Benilda Miranda Veloso
Published: July 2023

Este artigo analisa a relação entre a formação do pesquisador em nível de pós-graduação em contexto de pandemia e como este tem se organizado na UFPA e seus campi. A metodologia desta pesquisa foi orientada pelo Materialismo Histórico-Dialético com Abordagem Qualitativa, tendo como procedimento técnico o Estudo de Caso. Os resultados da pesquisa explicitam que 72% dos(as) discentes tiveram que alterar/adaptar o método da pesquisa durante a pandemia, além de dificuldades de acesso às tecnologias e à internet que os estudantes enfrentam. Conclui-se que essa formação online dificulta aos alunos construírem as condições de apropriação e efetivação do arcabouço teórico, metodológico e técnico, intrínseco à indissociável relação estabelecida entre a teoria e a prática na pesquisa científica.
TLR2 activates AP-1 to facilitate CTGF transcription and stimulate doxorubicin-induced myocardial injury
Authors: Cai Xinyong , Hong Lang , Zhan Yuliang , Liu Songtao , Zou Pengtao , Chen Yanmei , Shao Liang
Published: July 2023

Objective: Our study aimed to explore the mechanism network that
TLR2/AP-1 combined with SOX10 to activate the MAPK pathway via CTGF in
Dox-induced myocardial injury. Methods: Rats with Dox-induced myocardial
injury were treated with a TLR2 inhibitor or CTGF silencing lentiviral
vector. H9c2 cells were treated with genetic vectors or MAPK pathway
activators. Cardiac function was tested using echocardiography and serum
markers. H&E, sirius red, and TUNEL staining were used to detect
myocardial pathological changes, collagen accumulation, and apoptosis.
Western blot was used to detect proteins related to cardiac hypertrophy,
fibrosis, apoptosis, and MAPK pathway. H9c2 cell injury was assessed by
testing cell viability, LDH release, and mitochondrial membrane
potential. Results: TLR2 and CTGF were highly expressed in patients with
heart failure, and Dox treatment further increased their expression.
Inhibiting TLR2 or silencing CTGF improved cardiac function and reduced
myocardial fibrosis and apoptosis in Dox-treated rats. Silencing TLR2
alleviated Dox-induced H9c2 cell injury, which was nullified by CTGF
overexpression. TLR2 activated AP-1, which cooperated with SOX10 to
promote CTGF transcription. MAPK activation aggravated H9c2 cells
against Dox-induced injury. Conclusions: TLR2 activates AP-1 which
cooperates with SOX10 to promote CTGF transcription and subsequently
activate the MAPK pathway, thereby stimulating Dox-induced myocardial
injury.
A pH-responsive nanoparticle delivery system containing dihydrazidine and doxorubicin-based prodrug for enhancing anti-tumor efficacy
Authors: Zhang Lianxue , Huang Jianxiang , Buratto Damiano , Han Panli , Yang Zaixing , Zhou Ruhong
Published: July 2023

The efficacy of nanoparticle (NP)-based drug delivery technology is
hampered by aberrant tumor stromal microenvironments (TSMs) that hinder
NP transportation. Therefore, the promotion of NP permeation into deep
tumor sites via the regulation of tumor microenvironments is of critical
importance. Herein, we propose a potential solution using a
dihydrazidine (HDZ)-loaded nanoparticle drug delivery system containing
a pH-responsive, cyclic RGD peptide-modified prodrug based on
doxorubicin (cRGD-Dex-DOX). With a combined experimental and theoretical
approach, we find that the designed NP system can recognize the acid
tumor environments and precisely release the encapsulated HDZ into tumor
tissues. HDZ can notably downregulate the expression levels of
hypoxia-inducible factor 1α (HIF1α), α-smooth muscle actin, and
fibronectin through the dilation of tumor blood vessels. These changes
in the TSMs enhance the enrichment and penetration of NPs and also
unexpectedly promote the infiltration of activated T cells into tumors,
suggesting that such a system may offer an effective “multifunctional
therapy” through both improving the chemotherapeutic effect and
enhancing the immune response to tumors. In vivo experiments on 4T1
breast cancer bearing mice indeed validate that this therapy has the
most outstanding antitumor effects over all the other tested control
regimens, with the lowest side effects as well.
Polyvalent Anion-Induced J-Aggregation and Its Use in Ratiometric Fluorescence Tracking of Hypotonic in Arabidopsis
Authors: Li Chi , Zong Chong , Shen Lanbo , Lin Qiaowen , Wang Yumeng , Fu Jinyu , Chi Weijie , Liu Zhiqiang , Wang Kang-Nan , Yu Xiaoqiang
Published: July 2023

J-aggregate dyes have been widely used in biomedicine, chemical
engineering, etc., due to their structure and photophysical properties.
J-aggregation theory describes the nearest-neighbor molecules’
transition dipole moments in a sliding stacking arrangement. Recently,
we found that the intervention of polyvalent anions can induce the
J-aggregation of dyes via the intermolecular van der Waals interaction,
which is an essential way once overlooked. Experimental results and
theoretical calculations revealed that the more negatively charged or
large size of anions within a specific range, the more efficiently the
dye will form J-aggregates. As an application, the content of polyvalent
anion salts in a salt-stressed Arabidopsis model was evaluated based on
the ratiometric fluorescence emission resulting from the polyvalent
anion-induced dye J-aggregation.
Psychological and Physiological Motives in Humans (Study on Verses of The Qur'an)
Authors: Murjazin Murjazin , Nurhuda Abid , Susanti Linna , Azami Yasin Syafii
Published: July 2023

The Al-Qur'an is the official guideline and is an interesting material for Muslims to study because it is comprehensive about all aspects of life. This is proven, one of which is with several verses that explore the nature of human creation to the deviations it commits. So guidance, coaching, education, and healing are needed both from the psychological and physiological aspects. So the purpose of this study is to describe the Psychological and Physiological Motives in Humans (Studies on the Verses of the Qur'an). The method used is literature in the process of collecting data, then careful analysis is carried out, and finally, descriptive conclusions are drawn. The results of the study show that the physiological motives in the Qur'an are divided into two parts, namely the motive for being oneself and the motive for preserving offspring. While the psychological motives are divided into four parts, namely ownership motives, competition motives, hostility motives, and religious motives. These two things show how the Qur'an pays great attention to various kinds of matters including the different human souls and physiques so that it not only exhibits various kinds of heavenly pleasures and the pain of the torments of hell but also provides insight for humans regarding this matter things that are useful for their daily life.
Implementation of The Concept of 'Urf and Maslahah in Buying and Selling Gold With Non-Cash Payment (Comparative Study of Fatwa DSN-MUI and Fatwa Al-Lajnah Ad Dāimah Li Al-Buhūṡ Al-‘Ilmiyyah Wa Al-Iftā’ Saudi Arabia)
Authors: Jauhari Wildan , Abd Muhaimin Abd Wahab , Arif Khan Muhammad Dawud
Published: July 2023

The background of writing this research is to respond to differences in fatwas that occurred in two major fatwa institutions, namely the National Sharia Council of the Indonesian Ulema Council and Al-Lajnah Ad-Dāimah Li Al-Buhūṡ Al-'Ilmiyyah Wa Al-Iftā' State of Saudi Arabia; in the law of buying and selling gold in cash. This difference in fatwas confused the public and required descriptions and explanations regarding the methodology used by the two fatwa institutions. In this study, the authors used a qualitative method as a case study with a normative juridical approach. The results of this study are that the National Sharia Council of the Indonesian Ulema Council allows buying and selling gold in cash, either through ordinary buying and selling or buying and selling murabaha, as long as gold does not become the official medium of exchange (money). As for the fatwa of Al-Lajnah Ad-Dāimah Li Al-Buhūṡ Al-'Ilmiyyah Wa Al-Iftā' number 3211, it states that delaying the payment of gold is not permitted if it is exchanged for gold, silver, or equivalent (money).
Discrete mathematical modeling and optimal control of the marital status: Islamic polygamous marriage model case
Authors:   Fundamental and Applied Mathematics Laboratory (FAML), Department of Mathematics and Computer Science, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Sakkoum A. , Lhous M. ,   Fundamental and Applied Mathematics Laboratory (FAML), Department of Mathematics and Computer Science, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Rachik M. ,   Laboratory of Analysis Modeling and Simulation, Department of Mathematics and Computer Science, Faculty of Sciences Ben M'sik, Hassan II University of Casablanca, Tridane A. ,   Department of Mathematical Sciences, United Arab Emirates University
Published: July 2023

In this paper, we discuss a discrete mathematical model of Islamic polygamy and the social position of Muslims. In eleven compartments we explain the social situation and give an explanation of the marital status of each Males and females in Islamic societies that allow polygamy. In order to controlling and reducing the number of virgins men and women, divorced men and women we implement two control variables. The first control characterizes the benefits of an awareness campaign to educate virgin men and women about the benefits marriage to the individual and society, and the second control is about the legal procedures, administrative complexities and the grave financial and social implications of divorce. After that, we applied the optimal control theory to describe such an optimal strategies and finally a numerical simulation was performed to verify the theoretical analysis using a progressive-regressive discrete schema that converges following a convenient test related to the Forward–Backward Sweep Method (FBSM).
A new improved simulated annealing for traveling salesman problem
Authors:   Hassan II University, Fundamental and applied Mathematics Laboratory, Casablanca, Morocco, Adil N. , Lakhbab H. ,   Hassan II University, Fundamental and applied Mathematics Laboratory, Casablanca, Morocco
Published: July 2023

Simulated annealing algorithm is one of the most popular metaheuristics that has been successfully applied to many optimization problems. The main advantage of SA is its ability to escape from local optima by allowing hill-climbing moves and exploring new solutions at the beginning of the search process. One of its drawbacks is its slow convergence, requiring high computational time with a good set of parameter values to find a reasonable solution. In this work, a new improved SA is proposed to solve the well-known travelling salesman problem. In order to improve SA performance, a population-based improvement procedure is incorporated after the acceptance phase of SA, allowing the algorithm to take advantage of the social behavior of some solutions from the search space. Numerical results were carried out using known TSP instances from TSPLIB and preliminary results show that the proposed algorithm outperforms in terms of solution quality, the other comparison algorithms.
A new algorithm for solving Toeplitz linear systems
Authors:   SMAD Team, Polydisciplinary faculty of Larache, Abdelmalek Essaadi University, Tetouan, Morocco, Aoulad O. F. , Tajani C. ,   SMAD Team, Polydisciplinary faculty of Larache, Abdelmalek Essaadi University, Tetouan, Morocco
Published: July 2023

In this paper, we are interested in solving the Toeplitz linear systems. By exploiting the special Toeplitz structure, we give a new decomposition form of the coefficient matrix. Based on this matrix decomposition form and combined with the Sherman–Morrison formula, we propose an efficient algorithm for solving the considered problem. A typical example is presented to illustrate the different steps of the proposed algorithm. In addition, numerical tests are given showing the efficiency of our algorithm.
A numerical 3D fluid-structure interaction model for blood flow in an atherosclerotic carotid artery
Authors:   CEMAT-Center for Computational and Stochastic Mathematics, University of Lisbon, Portugal, Kafi O.
Published: July 2023

Compelling evidence shows the association of inflammation with atherosclerosis diseases, one of the leading cause of mortality and morbidity worldwide. Recent research indicated that the inflammatory process of atherosclerotic lesions is involved in the progression of atherosclerotic plaques in specific regions, such as the carotid bifurcation, which represents a risk for ischemic stroke as a result of the interaction between the blood and the plaque. We start modeling using 3D idealized geometry in order to capture the most important features of such interactions. Then, we proceed to a partly patient-specific computational domain representing an atherosclerotic artery. Understanding such interactions is of paramount importance preventing the risk of the plaque rupture. The numerical results comparisons have shown that, qualitatively, there is an agreement between idealized atherosclerotic artery and patient-specific atherosclerotic carotid artery. The idealized carotid geometry will be useful in future FSI studies of hemodynamic indicators based on medical images.