bluuebunny/crossref_metadata_2025 huggingface dataset:
Research Progress in the Treatment of Motion Sickness
Authors: Liang Kexin , Liu Yu , Wang Wenzheng , Geng Rongjing
Published: January 2023

Motion sickness is a disease characterized by vertigo, nausea, vomiting and other symptoms in traditional transportation and visual information technology. Signs of motion sickness occur in humans and animals when they are at sea, traveling by car or plane, and in space. In addition, some other special conditions, such as simulators, movie theaters, and video games, have also been described as causing pseudo disease. Treatment is directed towards reducing conflicting sensory inputs, speeding up the acclimation process, and controlling nausea and vomiting. At present, there are various clinical treatment methods, taking drugs to relieve vomiting is the main treatment method, but the effect varies from person to person. Therefore, this paper reviews the relevant data published in recent years, aiming to summarize the treatment methods of motion sickness, and provide a reference for the development of new treatment methods with small side effects and good efficacy to reduce the proportion of patients with motion sickness.
A review of the use of protein components in food for special medical purposes for cancer patients under the background of "mass health industry"
Authors: Wang Feifan
Published: January 2023

The cancer prevalence rate in China is rising year by year, while many cancer patients are suffering from protein malnutrition. The application of food for special medical purposes is a better nutritional treatment method, which can effectively reduce the incidence of malnutrition in tumor patients. However, at the present stage, China lacks special medical food for tumor, which leads to the unsatisfactory effect of nutritional treatment. Through reviewing the development of food for special medical purposes for cancer, and collecting and comparing the effects of various amino acids on tumor metabolism, this paper advocates introducing proteomics and molecular pharmacology ideas into design of special medical food for tumor. Based on the analysis of amino acid metabolism in the process of tumor development, this paper also introduces the specific methods and benefits of modifying the nitrogen source of protein components directly. These can achieve the effect of tumor immune nutrition regulation therapy, greatly reducing the incidence of malnutrition in tumor patients and improving the survival rate of them, which reduced hospital stay and medical expenses, consistent with the concept of developing the mass health industry in China. Therefore, more in-depth research and full use of the protein components in special medical food for tumor can improve the level of cancer treatment and accelerate the construction of mass health industry in China.
Development of PD-1 / PD-L1 in the treatment of liver cancer
Authors: Lin Xinyu
Published: January 2023

Liver cancer as the world ' s top five high incidence of malignant tumors, in the world, about 700,000 new cases of liver cancer patients each year, 1200000 deaths, in China, the incidence of liver cancer is also increasing year by year. As an immunotherapy, PD-1/PD-L1 inhibiting agent have shown certain advantages in the therapy of a variety of malignant tumors, but the quality of clinical treatment needs to be improved. Studies have shown that anti-angiogenic drugs and related treatments can synergistically improve the anti-cancer ability of PD-1/PD-L1 inhibitors. By combing the principle and application status of programmed death-1 and programmed death ligand-1 inhibitors for liver cancer, it is expected to improve the prognosis of patients with advanced lung cancer, and to explore the concurrent immune-related adverse reactions and efficacy evaluation indicators, so as to better apply in clinical practice and achieve satisfactory therapeutic effects.
Investigation of the interaction between glucose-6-phosphate dehydrogenase and ATA-inhibitor by molecular docking and molecular dynamics simulation
Authors: Cao Kun , Wang Ruonan , Li Ruixue , Xiong Xingdong , Liu Xinguang
Published: January 2023

Human glucose-6-phosphate dehydrogenase (G6PD) is a kind of polymerase, which can bind cofactors β-D-glucose-6-phosphate (G6P) and catalyzes NADP+ to produce NADPH. Therefore, G6PD plays a crucial role in maintaining reduced glutathione to protect cells from oxidative stress disorders. Aurine tricarboxylic acid (ATA) is a potential metal binding inhibitor. Here, we found that G6P and ATA have a common potential binding site in the G6PD receptor conformation through molecular docking. The results of molecular dynamics (MD) simulation showed that, compared with apo-G6PD, G6P-G6PD and ATA-G6PD had lower root mean square deviation (RMSD), radius of gyration (Rg), and solvent accessible surface area (SASA), indicating that binding ligand molecules could promote the overall conformation of G6PD to be more stable. These results suggest that ATA may compete for the binding sites of G6P, thereby inhibiting the catalytic function of G6PD. This study revealed the mechanism of interaction between ATA inhibitors and G6PD at the atomic conformation level, providing a theoretical basis for investigating the effects of cellular oxidative stress.
Well head multi parameter data monitoring system based on LoRa
Authors: Tang Shufa , Guo Liang
Published: January 2023

Oilfield wellhead data is an important indicator to reflect the normal operation of oil well equipment. This paper monitors the data of standpipe pressure, hanging weight, torque and other parameters, which is helpful to improve the safety and production efficiency of the entire oilfield. Therefore, this paper proposes a set of multi parameter monitoring system based on LoRa to further explore and study in order to reduce oilfield accidents.
Research on Innovative application of private intangible cultural heritage digitization from the perspective of rural revitalization
Authors: Chang Anni , Wu Yanfa
Published: January 2023

In the context of rural revitalization strategy, this study focuses on how folk intangible cultural heritage provides new ideas for rural revitalization, and further discusses the innovative application of digitalization and intangible cultural heritage. This paper first explains the intangible cultural heritage, and reviews the current situation of the protection and inheritance of domestic intangible cultural heritage. Secondly, it analyzes some problems and principles to be adhered to in the integration of digitalization and intangible cultural heritage. Finally, under the concept of meta-universe, the paper breaks through the obstacles of intangible cultural heritage in time and space, and puts forward corresponding schemes to promote the rural revitalization strategy of intangible cultural heritage empowerment.
Application of data visualization technology in University library service
Authors: Cheng Xiang
Published: January 2023

This paper introduces the role of data visualization in the development of information service in the library, as well as the role in scientific research and teaching. Through the analysis of the research status at home and abroad, it is concluded that the university library can establish a perfect service system in terms of data visualization service from the aspects of providing basic services of data literacy, enriching data information resources, training data librarians and service teams, participating in the whole process of data service, opening up the physical space of data service and establishing the platform of data visualization knowledge exchange. At last, it gives the strategy of developing the data visualization service in the library, including training the data librarian, reconstructing the information service system, realizing the whole-process service method, establishing the multi-participation service platform and carrying out the data literacy education reform. The aim is to provide a preliminary method for the library to carry out data visualization service and improve the library service efficiency.
Effects of Tannin-containing Supplement on Enteric Methane Emissions, Total Digestible Nutrient, and Average Daily Gain of Local Indonesian Beef Cattle
Authors: Ramaiyulis Ramaiyulis , Metri Yurma , Irda Irzal , Kurnia Dihan , Syukriani Debby
Published: January 2023

Reducing methane (CH4) emissions is one of the most critical goals in ruminant nutrition. This study aimed to evaluate the effect of concentrate and tannin supplementation on the mitigation of methane gas in Indonesian local beef cattle. The current study was conducted in vivo using 12 Bali cattle using a completely randomized design with four treatments and three replicates. Cattle were fed a basal ration with field grass (control), the addition of concentrate 25% dry matter (DM) ration no tannin as well as tannin supplemented in concentrate at levels of 0.12% and 0.18% of DM concentrate. The concentrate contains 7.5% crude protein and 71.25% total digestible nutrients and tannin supplementation using gambir (Uncaria gambir Indonesia) tannin extract. The parameters measured were apparent digestibility, total digestible nutrients, methane production, and average daily gain. The results showed that concentrate addition significantly increased DM consumption, crude protein digestibility, and total digestible nutrients. Supplementation of 0.18% tannin in concentrate can mitigate 49.7% methane gas production resulting in energy efficiency, which was reflected in the weight gain rate of 0.75 kg/day. In conclusion, present results suggest that the supplementation of 0.18% gambier tannin extract in concentrate could be considered a suitable feed additive to mitigate methane gas production and increase the average daily gain of Indonesian local beef cattle.
Deterioration of Frozen Semen of Bali Cattle after Cooling at 5°C
Authors: Tethool Angelina Novita , Ciptad Gatot , Wahjuningsih Sri , Susilawati Trinil
Published: January 2023

Frozen semen is produced through several stages, which deteriorate spermatozoa. This research aimed to evaluate the deterioration degree of frozen semen after 5 °C cooling and freezing of Bali cattle. The samples included 10 male Bali cattle with a body weight of 542-668 kg, from which semen was collected once a week for five weeks. The deterioration of each individual’s sperm was determined by observing two distinct straws. The parameters observed included viability, abnormalities, intact plasma membrane, and intact acrosome cap. Initial observations of the parameters were conducted following the addition of semen to diluent A1 (AD) as much as the volume of fresh semen. The semen in the AD group was not cooled and frozen. The A1 semen was then divided into two, namely, those with cooling at 5 °C for 4 hours (PT1) and at 5°C for 22 hours (PT2). The results showed that individual variations in Bali cattle caused significant differences in viability and intact plasma membrane of AD and PT1 groups, while PT2 did not differ in viability and intact plasma membrane spermatozoa. Abnormalities were significantly different between AD and PT2 groups, however PT1 did not differ in abnormalities spermatozoa. Intact acrosomal cap was significantly different in the AD, PT1, and PT2 groups. In conclusion, individual variations, including viability, abnormalities, intact plasma membrane, and acrosome cap of spermatozoa, were better at 4 hours compared to cooling at 5°C for 22 hours. A Cooling time of 4 hours at 5°C can be recommended for frozen semen processing.
Effects of Ascorbic Acid on Maturation Rate, Morphology, and Gene Expression of Vitrified In Vitro Matured Dromedary Camel Oocytes
Authors: Kandil Omaima Mohamed , Aboelwafa Fatma Badawy , Ismail Esraa Aly , Kandeel Sahar Mohammed , Ghanem Nasser , Gamal El-Din Abd El-Kader
Published: January 2023

In vitro embryo generation, cryopreservation, and embryo transfer are examples of assisted reproductive technologies that can be used to improve camel genetic performance and fertility. The aim of this study was to investigate the impact of ascorbic acid supplementation to in vitro maturation media on the maturation rate, morphology, and gene expression of fresh and vitrified in vitro matured dromedary camel oocytes. In the current study, 810 oocytes of excellent and good quality were in vitro matured in maturation medium (TCM-199 + 10 ug/ml follicle stimulated hormone + 10% fetal calf serum + 100 IU/ml Pregnant mare serum + 50 μg/ml gentamycin) without any additives to act as a control group (C) and with 50 μg/ml ascorbic acid group (AA) and incubation in a CO2 incubator (38.5 ̊C, 5% CO2, 20% O2 and 95% humidity) for 40 hours. In vitro matured dromedary camel oocytes with the first polar body (n = 210) in C group and AA group (n = 250) were placed in basic medium (BM) and then placed in vitrification solution1 (VS1) for one minute, followed by the transfer of oocytes to VS2 (double concentration of VS1, containing 20% Ethyl Glycol (EG) and +20% Dimethyl sulfoxide) for 30 seconds. Oocytes were then loaded into sterile 0.25 ml straws and stored in liquid nitrogen for 7-10 days. The normal fresh and vitrified /thawed in vitro matured dromedary camel oocytes were kept in RNA later at a -80°C freezer for gene expression analysis. The maturation rate of dromedary camel oocytes in the in vitro matured AA group was significantly higher than that of the C group. The percentage of normally recovered vitrified/thawed oocytes was higher in the in vitro matured with ascorbic acid (VAA) than in the control (VC) group. The expression pattern of the SOD1 gene and GDF9 gene was upregulated in fresh AA and VAA groups than in the fresh C and VC groups. The profile of the SOD1 gene was more abundant in the vitrified/thawed oocytes VAA group than in the VC group. All vitrified/thawed groups, whether control or ascorbic acid supplemented, had lower levels of SOD1, GDF9, and BMP15 expression, compared to the fresh groups. In conclusion, the supplementation of the maturation medium with ascorbic acid has an increased maturation rate, and normal morphology of vitrified/ thawed oocytes which was linked with upregulation of SOD1, GDF9 genes expression.
Using Mobile Phone Based Tasks to Improve Jordanian Grade 7 EFL Students’ Composition Writing Skills
Authors: Almawadeh Nofah Sameh
Published: January 2023

This study investigated the effectiveness of using mobile phone based tasks to improve the FL composition writing skills of 52 Jordanian grade 7 students. They were divided into two groups; control and experimental groups. The control group included 24 students, while the experimental group included 28 students. Data were collected through a pre-test and a post-test of FL composition writing. The mixed method of quantitative and qualitative analysis was used. Data were analyzed using the Paired-Samples T-Test. In addition, the use of the independent samples T-Test aimed to determine the statistical significance of the two tested groups’ performance in FL composition writing. The findings affirmed the effectiveness of using mobile phones in improving the FL composition writing skills of Jordanian grade 7 students.
Questão social, Serviço Social e a pandemia: dilemas e tendências
Authors: Bezerra Angélica Luiza Silva , Medeiros Milena Gomes de
Published: January 2023

O texto aborda a questão social e o Serviço Social, mediados pela ativação dos limites absolutos do capital, no contexto de uma crise sanitária que agravou as condições de vida dos trabalhadores. Do ponto de vista dos procedimentos metodológicos, utilizou-se uma revisão bibliográfica de natureza qualiquantitativa, fundamentada principalmente nas formulações de Karl Marx e István Mészáros, como também dados estatísticos provenientes da síntese dos indicadores sociais do IBGE/2020; do relatório da Cepal/2020 sobre a pandemia da covid-19 e os efeitos econômicos e sociais; do relatório da Oxfam Brasil/2021; entre outros. A produção destrutiva do capital, aliada à crise sanitária impulsionada pela covid-19, tem alterado as condições em que se expressa a questão social, assim como as respostas políticas e econômicas do Estado em face da atual calamidade pública, trazendo consequências de ordem teórica, política e social para o Serviço Social.
Evaluation of Endometriosis and Uterine Fibroids Leading to Infertility in Females Using Ultrasonography
Authors: Noor Izza , Hina Gull E , Jabeen Faiza , Javed Nauman
Published: January 2023

The most common complaint among women who visit for an ultrasound is infertility, and ultrasound should be the first imaging technique to assess these patients. Objective: The aim of this study is to study uterine fibroids and endometriosis causing infertility in females using ultrasonography. Methods: The study was carried out in Gujranwala Pakistan at Chatha Hospital, Gondal hospital, and Al-Amin diagnostic center. The sonographic scanning of the 95 patients are included in the study. The bladder must be sufficiently filled; the lower abdomen should be lubricated with a coupling agent. Start by scanning transversely from the symphysis pubis to the umbilicus. Then, tilt the probe sharply downward until the uterus appears in the center of the screen and the endometrial line is visible. Finally, increase the image's gain and freeze the result. Results: The uterine fibroids and endometriosis are mainly affected in the age group of 30-39 has the highest frequency of (44.2%). The Ultrasound finding of the disease is such that endometriosis has the frequency of 23(24.2%) patients and the uterine fibroids have the frequency of 43(45.3%) patients. Secondary infertility has a maximum frequency of patients that is 51(53.7%) and primary infertility has a minimum frequency of patients that is 44(46.3%). Conclusions: In this study, uterine fibroids and endometriosis cause infertility in women between the age between 20 years to 60 years. More females are affected at the age of 30-39 years. More infertility is caused by uterine fibroids.
The Role of Ultrasound in the Diagnosis of Pelvic Pain in Non-Pregnant Females
Authors: Fatima Noor , Hina Gull E , Imran Ayesha , Khalid Quratulain
Published: January 2023

Pelvic pain is the most common concern among women who visit the ER, and ultrasonography should be the first imaging method used to evaluate these patients. Objectives: To evaluate how well ultrasonography could diagnose different causes that can lead to pelvic pain in women. Methods: A cross-sectional study was held at Chatha Hospital, Al Amin Diagnostic Center, and Gondal Hospital. It used B mode ultrasonographic capability and in order to avoid artifacts or attenuation, an ultrasonic gel is applied to the transducer. Hospitals were legally authorized to take the information. Inclusion criteria were used to determine patient eligibility. Results: The commonest ultrasonography findings of pelvic pain were an ovarian cyst in 16 out of 97 which were 16.4%, bulky uterus with fibroid in 26 patients (26.8%), endometriosis in 4 patients (4.1%), ovarian enlargement in 3 patients (3.1%), endometriotic cyst in 6 patients (6.2%), RPCOs in 8 patients (8.2%), PCOs in 9 patients (9.3%), hydronephrosis in 4 patients (4.1%), fluid in cul de sac in 7 patients (7.2%), thickened endometrium in 3 patients (3.1%), pelvic inflammatory disease in 5 patients (5.2%), appendicitis in 4 patients (4.1%), and inguinal hernia in 2 patients (2.1%).  Conclusions: Ultrasound scanning is a critical modality for detecting pelvic changes in female patients. The most common cause of pelvic in females is uterine fibroid and ovarian cyst. Moreover, pelvic pain occurs most frequently during the reproductive age and less frequently during menopause
Assessment of Liver Diseases Using Triphasic Computed Tomography
Authors: Jabeen Faiza , Noor Izza , Khalid Quratulain , Fatima Noor
Published: January 2023

The triphasic spiral liver computed tomography (CT) method is a standard way to find and describe a wide range of benign and cancerous liver lesions. This helps bring down the rates of death and illness among people with liver disease. Objective: To evaluate liver diseases in real time using Triphasic imaging procedure. Methods: A cross-sectional study was carried out at Al-Amin Diagnostic Center, Chattha Hospital, and Gondal Hospital. Before Triphasic CT Scan, each patient completed a form of written informed consent.  A total of 65 people were examined. All diagnosed with various liver illnesses, as well as their findings were reviewed using  Triphasic liver CT Scan. The typical patient was 53.5 years old. Patients' eligibility was determined using inclusion criteria. Results: The majority of data population was male 39 (60%) and female 26 (40%). The majority of the findings included Portal vein thrombosis 6 (9.2%) liver lesion 5 (7.7%), ascitis 3 (4.6%), cirrhosis of liver 6 (9.2% ), Hepatocellular carcinoma 12 (18.46% ), Dilated CBD 4 (6.2% ), cholilithiasis 8 (12.3%), portal hypertension 5 (7.7%), hepatic Mets 6  (9.2%), Hepatic contusion 6 (9.2%), Right lobe nodules 3  (4.6%), segment 8 tumor  1 (1.5%). Conclusions: Computer tomography is a useful modality for identifying liver pathology. sixty-five patients in this study were aged 30-84 years (60%) male and (40%) female and were found to have a greater incidence of hepatic cellular carcinoma in the liver (12) (18.46%) and it is more affected in males than females
IL-6 as an Inflammatory Marker in Hodgkin Lymphoma
Authors: Tariq Muhammad Akram
Published: January 2023

Hodgkin lymphoma (HL) is a lymphoid tumor that develops from embryological or post-germinal center B-cells. The disease was originally recognized in 1832 by Thomas Hodgkin. Globally, 0.4% of clinically diagnosed cancers in 2018 were caused by HL. Regardless of age, ethnicity, or location, the prevalence of HL varies. It's a particular kind of malignant tumor in which the cancerous Hodgkin and Reed-Sternberg (HRS) cells are surrounded by a significant cellular infiltration of immune cells (lymphocytes, macrophages, eosinophils, mast cells, plasma cells, and collagen cells), which also contribute to the microenvironment of the tumor. Numerous chemotherapy drugs and low-dose field radiation have been found to significantly reduce illness mortality [1].

High levels of cytokines that stimulate the immune system, such as interleukin (IL)-6, tumor necrosis factor (TNF), and eotaxin are produced by developing tumor cells and/or by reactive immune cells associated with tumors. These markers are anticipated to promote B-cell activation and related high-risk DNA-modifying activities, which will lead to the growth of B-cell lymphoma. IL-6 is a critical cytokine that stimulates the growth of hematological and solid tumors and is synthesized by a wide range of cell types, including fibroblasts, ECs, epithelial cells, and monocytes as hematological tumor lines. Through the activation of JAK, it stimulates the transcription factors STAT. In NHL, lower progression-free survival and overall survival rates have been linked to higher blood IL-6 levels, and IL-6 production in HL cell lines has been demonstrated. Numerous investigations revealed that IL-6 expression correlated with early onset vascular development events, indicating that it may be involved in angiogenesis [2].

Interleukin-6 (IL-6) is thought to play a crucial pathobiological function in classical HL among the biologic variables like cytokines. According to reports, adult patients with HL who have elevated serum interleukin-6 (IL-6) have better response rates, longer survival times, and B symptoms. TH-17 response may be elicited by HRS cells that express IL-6, but TH-2 response may be elicited by HRS cells that do not express IL-6. T-lymphocytes are known to be attracted by IL-6, and depending on how it interacts with other cytokines like TGF-beta, the lymphocytes may induce a TH-2 or TH-17 response. A significant cancer hallmark known as immune evasion can be brought on in cancer patients by the TH-2 response [3].
Prevalence of Musculoskeletal Sports Injuries of Head, Neck and Upper Limb among Cricket Players
Authors: Hussain Umar Mutahhar , Batool Sana , Bano Javaid Hira , Sheraz Zainab
Published: January 2023

Sports injuries have been reported with growing rate in a quest to identify patterns by which they can be predicted and prevented. Injury investigation in cricket has been started for almost twenty years. Objective: To determine the prevalence of musculoskeletal sports injuries of head, neck and upper limb among cricket players. Methods: It was a Cross-sectional study. Data were taken from 180 selected cricket players from different cricket academies, clubs of Lahore Pakistan. The data were analyzed by SPSS version 21 and with a self-generated questionnaire. Results: This study showed very low prevalence of head and neck injuries which is 5.6 % and very high prevalence of shoulder injuries are seen in this study which is 77.78 %. Elbow injuries are seen 19.4 % while there is a significant association between type of cricketers and shoulder pain. Conclusions: The prevalence of musculoskeletal sports injuries found very high in shoulder joint, then in elbow joint and then in head and neck which has affected their performance. Study also showed a significant correlation between the type of players and shoulder pain
Multidrug-resistant Staphylococcus aureus isolated from chicken nuggets sold at superstores in Mymensingh, Bangladesh
Authors: Ain Qurra , Arif Mohammad , Ema Fateha , Shathi Most , Islam Md , Khatun Mst
Published: January 2023

Objective: This study was conducted to determine the colony forming units (CFU) to isolate, identify, and antibiotic sensitivity of Staphylococcus aureus from chicken nuggets (CN).
Materials and Methods: Sixty CN samples from two brands were collected from different super¬stores in Mymensingh, Bangladesh. Uncooked, oven-cooked (OC), or gas stove-cooked (GSC) CN samples were inoculated onto mannitol salt agar and blood agar.
Results: The total staphylococcal count (TSC) for uncooked CN ranged from log 4.68 to log 5.11 CFU/gm. For OC CN, TSC ranged from log 3.29 to log 3.62 CFU/gm. For GSC CN, TSC ranged from log 3.09 to log 3.49 CFU/gm. Relative to uncooked CN, microwave oven-cooked and GSC samples significantly reduced the TSC of CN (p < 0.01). Using the polymerase chain reaction assay and standard biochemical testing, only 8 out of 60 CN samples contained S. aureus. Staphylococcus aureus were resistant to Ampicillin (100%), Amoxicillin (100%), Oxacillin (75%), Cefixime (87.5%), Doxycycline (75%), intermediately sensitive to Erythromycin (25%), Cephalexin (12.5%), Ciprofloxacin (25%), Gentamicin (12.5%), Doxycycline (12.5%) and sensitive to Oxacillin (25%), Azithromycin (100%), Erythromycin (75%) Cephalexin (87.5%), Cefixime (12.5%), Chloramphenicol (100%), Ciprofloxacin (75%), Gentamicin (87.5%), Doxycycline (12.5%), and Vancomycin (100%).
Conclusion: This study reports the first isolation and identification of S. aureus from CN in Bangladesh. GSC CN was better than OC and uncooked CN. Data also suggest that CN is contami¬nated with multidrug-resistant S. aureus, which poses a public health hazard.
groEL gene-based molecular detection and antibiogram profile of Riemerella anatipestifer from duck in Bangladesh
Authors: Hasan Alamgir , Bose Palash , Aktar Mst , Haque Zobayda , Islam Mohammad , Hossain Muhammad , Siddique Mahbubul
Published: January 2023

Objectives: This study was designed to detect Riemerella anatipestifer through polymerase chain reaction (PCR) from duck farming areas of the Mymensingh and Sylhet divisions and to determine the antibiogram profile of the PCR-positive isolates using the disc diffusion method.
Materials and Methods: Fifty two samples were collected, comprising clinically sick (32 ducks) and dead ducks (20). PCR confirmation was accomplished, and consistent findings were observed, employing R. anatipestifer groEL (271-bp) gene as appropriate molecular markers. For further clarification, see R. anatipestifer specific PCR assay (546-bp) and gyrB-based PCR (162-bp) were also done. The disc diffusion method was followed for the antibiotic susceptibility test of the iso¬lates against commonly used antibiotics.
Results: A total of 21 samples, 8 from clinically sick birds and 13 from dead birds, showed positive results in both conventional and molecular assays out of 52 samples. High occurrences were found in oropharyngeal swabs from sick ducks and the liver and heart from dead ducks. Antibiotic susceptibility testing revealed that the isolates were 100% resistant to penicillin G, cefradine, streptomycin, neomycin, gentamycin, meropenem, and erythromycin, but 100% sensitive to cotrimoxazole, florfenicol, and levofloxacin.
Conclusion: For diverse duck-populated areas in Bangladesh, this study shows the severity of R. anatipestifer infection among ducks.
Influence of Nano-Methionine supplementation in drinking water on growth performance, lipid metabolism, and related gene expression in broiler chicken
Authors: Shobokshy Set , Samaha Magda , Maksoud Eman , Khatab Shymaa , Khafaga Asmaa , Wirtu Gemechu
Published: January 2023

Objectives: The study aimed to determine how Nano-Methionine (Nano-Meth) affected growth, lipid metabolism, and relative gene expression for acetyl-CoA carboxylase (ACC), fatty acid syn¬thase (FAS), growth hormone receptor (GHR), insulin-like growth factor receptor-1 (IGFR-1), myo¬statin (MSTN), and cholecystokinin (CCK) genes in broiler chickens.
Materials and Methods: A total of 100 1-day-old broilers were randomly assigned into 2 groups: 1) the control group received drinking water without any supplements, and 2) the Nano-Meth group received 10 ml/l of 5% Nano-Meth starting from 1 day old until 35 days old (the end of the experiment).
Results: Nano-Meth improved final body weight, weight gains, feed intake, and feed conver¬sion ratio. Compared to the control group, Nano-Meth significantly lowered the serum levels of triglyceride, cholesterol, very low-density lipoprotein, and low-density lipoprotein in chickens. Nano-Meth significantly increased the serum levels of total protein, albumin, high-density lipo-protein, and glucose more than the control group. Nano-Meth lowered the mRNA gene expression of ACC, FAS, MSTN, and CCK but increased that of GHR and IGFR-1.
Conclusions: We concluded that supplementation with Nano-Meth enhances growth performance and decreases lipid accumulation in broiler chickens.
Cassava pulp added to fermented total mixed rations increased tropical sheep’s nutrient utilization, rumen ecology, and microbial protein synthesis
Authors: Khejornsart Pichad , Meenongyai Watcharawit , Juntanam Theerayut
Published: January 2023

Objective: The price of animal production will be affected by the significant increase in feed costs. The objective of this research was to investigate the impact of adding waste cassava pulp to fer¬mented total mixed ration (FTMR) on nutrient utilization, rumen ecology, and microbial protein synthesis in tropical sheep.
Materials and Methods: A 3 × 3 replicated Latin square design was used to randomly arrange nine crossbreed lambs (Santa Inês × Dorper) with an initial body weight (BW) of 18.7 ± 1.6 kg (mean ± SD). During a 21-day trial, the animal was offered a random selection of concentrate diets and rice straw (control), total mixed ration (TMR), or FTMR. During the investigation, data on nutrition utilization, rumen ecology, and microbial protein synthesis were analyzed using analysis of variance.
Results: The finding shows that FTMR had significantly higher dry matter (DM) intake and DM intake per BW than either TMR or control (p < 0.05). Lamb fed on FTMR had significantly higher DM, organic matter protein, crude protein, and neutral detergent fiber digestion than those on control or TMR (p < 0.05). Rumen pH values for all treatments ranged from 6.68 to 6.73, with no significant differences. Growing lambs fed FTMR had greater rumen total volatile fatty acid and propionic acid concentrations than those given TMR and the control (p < 0.05). Protozoa were not different across the FTMR groups, although total bacterial and fungal zoospores were increased. In addition, when lambs were fed FTMR containing cassava pulp, ruminal microbial protein syn¬thesis was significantly increased.
Conclusion: It could indicate that feeding growing lambs with FTMR could improve nutrient utili¬zation, ruminal fermentation, and microbial protein synthesis. However, studies on the effects of FTMR on sheep performance, meat quality, and milk quality are necessary.
Changing trends in medical education during pandemic: our experiences on E learning
Authors: Begum Massarat , Chalam Pindicura
Published: January 2023

The COVID 19 pandemic has lead not just to a social and economic uncertainty but also created historic challenges to the continuity of education process globally. Online teaching and learning has come to the forefront to prevent loss of learning time for students during this period. An observational cross sectional study was conducted on the implementation of online teaching program in a medical college during the period of COVID 19 pandemic. All the synchronous and asynchronous teaching learning activities across all the phases of MBBS were observed and reviewed. The challenges, limitations and opportunities in the implementation process were analyzed. Appropriate solutions were found for most of the challenges including the implementation of competency based undergraduate curriculum for phase 1 MBBS students. Feedback was taken from the undergraduate medical students to know their perceptions on e learning and its use as a teaching learning method. The questionnaire included both closed and open ended questions to know the learning experiences and preferences of the students. The data was subjected to descriptive statistics and computed as frequency percentages. The study presents the challenges in the implementation of online teaching like providing the required infrastructure and training the faculty. It also reveals its limitations in providing clinical experience and conducting assessments for students. The study also shows that though the medical students perceived various features of e learning to be useful but believed traditional classroom to be a better learning environment. The study highlights that e learning has provided the opportunity to promote self directed learning for students and to develop technological skills of both the faculty and the students, suggesting its potential role in the future of medical education.
Is nucleic acid amplification test sufficient enough for reducing the diagnostic dilemma of cervical lymph node tuberculosis? A descriptive study in a tertiary care hospital
Authors: Jana Sritanu , Mukhopadhyay Debasis , Bagdi Sunita , De Arindam , Pathak Swapan
Published: January 2023

Background: Pulmonary tuberculosis (TB) is common clinical presentation in India, but, nowadays, extrapulmonary TB (EPTB) is also a clinical problem. At present, no single test is available for diagnosing EPTB which is rapid, cost-effective, and confirmatory. Many studies were done to diagnose and treat the pulmonary TB, though more efforts are needed for diagnosis of EPTB.

Aims and Objectives: The aim of this study is to find out any test or a series of tests that reduce the diagnostic dilemma of cervical lymph node TB.

Materials and Methods: A total of 170 patients with cervical lymphadenopathy were enrolled in the pathology department between July 1, 2021, and December 31, 2021. It was a descriptive study and of cross-sectional design. The Institutional Ethics Committee approval was received (No. BSMC/IEC/101 dt. January 15, 2021). Suspected malignancy cases were excluded from the study. Fine-needle aspiration (FNA) was done for all these patients and stained with Leishman-Geimsa, Papaniculaou, and Zeihl-Neelsen (ZN) stain. After FNA, all samples were sent for cartridge based nucleic acid amplification test.

Results: After FNA cytology, ZN stain was done and only 9.2% of acid–fast bacilli (AFB) positive cases were found. Granuloma was found in 27.6% of cases. After nucleic acid amplification test (NAAT) study, it was found that 36.8% patients were positive. Total number of lymph node considered to be positive for TB (NAAT positive and/or ZN stain positive and/or presence of granuloma) is 85 (52.1%). As per conventional method for diagnosis of lymph node TB (presence of granuloma and/or AFB positive in ZN stain), number of cases were 50 (30.7%). NAAT test was significantly more positive in respect of ZN staining but not significantly positive in respect of presence of granuloma.

Conclusion: For diagnosis of cervical lymph node TB, all three methods (NAAT, ZN stain, and Leishman-Giemsa stain) should be used simultaneously.
TO THE QUESTION OF THE FORMATION AND DEVELOPMENT OF FINANCIAL INCLUSION IN KAZAKHSTAN
Authors: Smolyaninova S. F.
Published: January 2023

The purpose of this article is to study the formation and development of financial inclusion in Kazakhstan. In modern realities, digital technologies are the engine of innovation, competition and economic growth. The author singled out a number of factors influencing its development. These technologies make it possible to level barriers in the accessibility of financial services, that is, to increase financial inclusion.
ASSESSMENT AND ROLE OF MIGRATION PROCESSES IN THE NORTH KAZAKHSTAN REGION
Authors: Suyundykova D. B.
Published: January 2023

This article is devoted to the current problem of the influence of migration processes on the socio-economic development of the region. Its purpose is to assess the dynamics and intensity of migration processes and determine their role in ensuring the socio-economic development of the North Kazakhstan region. In the process of preparing this article, such research methods as analysis and synthesis, structural approach, historical and statistical approach were used. The results of the study confirm the hypothesis that the trends of migration processes in the North Kazakhstan region hinder the socio-economic development of the region. The results of the research will become the basis for the author's further scientific work on his master's thesis.
METHODS OF TEACHING PHYSICS WITH REFERENCE TO THE SUBJECT BIOLOGY
Authors: Kozhabekova E. K.
Published: January 2023

The world is experiencing a global explosion of knowledge, which is the driving force of science and technology. Science and technology originate in an adventurous workforce well-equipped with basic scientific knowledge. No subject can be taught in isolation, like teaching physics. For effective learning, it is necessary to use all the advantages of the interconnections and applications of the subject of physics. In addition to the connection with other disciplines and everyday life, physics can have many connections with scientific disciplines. The artificial division of science into different spheres is a matter of convenience, not necessity. On this basis, many teachers advocate the introduction of curricula based on the relationship between different subjects. These types of training programs give more importance to our classroom instructions. There are various inventions in the physical development of our society, so physics makes a great contribution to the development of some other disciplines. Currently, we cannot find something that does not require knowledge about science, there are many specialties that have never existed before, for which the study of science is a basic requirement, for example, medicine, engineering, agriculture, paramedics, computers, etc. Thus, in order to get any such professional, it is necessary and, consequently, school curricula, i.e. a system of interdisciplinary communication is introduced in the description of the subject. This suggests that for the scientific progress of the country, the educational sector needs to prepare people with a scientific mindset. However, all over the world, modern youth do not understand the main differences in the teaching of natural sciences, that is, physics and biology, in educational centers. In this context, we emphasize the main relevance of the article.
PRODUCTION ACTIVITIES OF THE STATE SEWING FACTORY “BOLSHEVICHKA” IN KOSTANAY IN 1942
Authors: Aitmukhambetov A. A. , Bekmagambetov S. B.
Published: January 2023

As a result of the threat of German occupation of the western regions of the USSR, the state leadership decided to evacuate the population and strategically important enterprises to the eastern regions. In the summer[1]autumn of 1941, the Bolshevichka factory was evacuated from Kherson to Kostanay. From the moment of arrival at a new destination, the process of reorganization of the work of the factory team begins. Based on archival materials, the article examines the systematization of the factory during this period.
MUSEUM TOURISM IN NORTHERN KAZAKHSTAN: PROBLEMS AND PROSPECTS OF DEVELOPMENT
Authors: Bekmurzina A. N. , Aubakirova G. R. , Zhakezhan S. A.
Published: January 2023

The Museum is a socially significant institution that is engaged in the identification, preservation, study and popularization of heritage. And tourism is becoming an integral part of modern society. Modern museums are designed to respond to the challenges of the time, become attractive to tourists and participate in the development of tourism business. The article emphasizes the special importance and necessity of cooperation between museums and tourism business. Based on the analysis of scientific literature, documents and statistical sources, the tourist resources of the museums of the Northern Territory are considered, the main problems of this sector and the ways of its further development are identified. Museum tourism at the present stage is considered as a promising direction.
COMPORTAMENTO DESVIANTE NO AMBIENTE DE TRABALHO E LIDERANÇA TÓXICA: UM ENSAIO TEÓRICO
Authors: Ferreira João Cesar de Souza
Published: January 2023

Este ensaio teórico realiza um estudo o qual busca propor uma relação entre liderança tóxica e comportamento desviante no ambiente de trabalho. Por meio de levantamento bibliográfico propomos que líderes tóxicos tem uma relação com a forma como seus liderados se comportam no ambiente de trabalho, para tanto, pressupõe a existência de uma dinâmica que denominamos cadeia de desvio. A resposta do liderado a presença de um líder tóxico, pode ocorrer por identificação, submissão e oposição tendo moderador a liderança tóxica na propensão ao comportamento desviante no ambiente de trabalho por parte de seus liderados, constituindo uma cadeia de desvio organizacional.
CRIAÇÃO ARTEFATO POKA YOKE PARA A INSPEÇÃO DE TUBOS DE SEÇÃO CIRCULAR VIA MANUFATURA ADITIVA
Authors: Dias Leandro Antunes , Galhardi Antonio Cesar
Published: January 2023

Esta pesquisa apresenta a criação de um artefato para a resolução de um problema referente ao diâmetro externo acima da tolerância máxima de tubos de aço da norma NBR 6591. A partir da utilização do método Design Science Research foram desenvolvidos dois artefatos, com características das ferramentas Poka Yoke, usados na detecção dimensional do diâmetro externo dos lotes reclamados e de outras peças no estoque de clientes. Esses dispositivos foram modelados e confeccionados utilizando a Manufatura Aditiva via tecnologia de impressão 3D. O Design Science Research proporcionou uma visão sistêmica sobre os passos a serem seguidos e incorporou na resolução de um problema prático, todo o rigor e a relevância que uma pesquisa científica necessita para a criação dos artefatos. O estudo atingiu o objetivo da pesquisa uma vez que foram criados artefatos capazes de medir o diâmetro externo e classificar grande quantidade de peças, em aprovadas e reprovadas.
ANÁLISE DO DESEMPENHO FINANCEIRO DAS INDÚSTRIAS CERAMISTAS COM GESTÃO AMBIENTAL NO SERTÃO DO NORDESTE BRASILEIRO
Authors: Duda Edivaldo do Nascimento , Da Silva Letícia Maria , Dos Santos Jaciane Cristina , De Assis Iara Ingrid , de Queiroz Luziana Maria Nunes , Lagioia Umbelina Cravo Teixeira , Valentim Maria do Socorro , Araujo César Augusto de Albuquerque
Published: January 2023

Desde a revolução industrial, as indústrias e empresas provocaram ao longo dos anos, sérios danos ao meio ambiente. Na tentativa de reverter essa situação, algumas ações sustentáveis estão sendo tomadas pelas entidades. No município de Parelhas, localizada no interior do estado do Rio Grande do Norte, algumas indústrias ceramistas têm buscado utilizar técnicas de gestão ambiental, a fim de implantar uma produção mais “limpa”, sem necessariamente precisar diminuir sua rentabilidade. Diante desse contexto, o objetivo da pesquisa foi analisar as práticas sustentáveis implantadas por empresas voltadas para o desenvolvimento e gestão financeira. Realizou-se uma pesquisa qualitativa de natureza descritiva, aplicando um estudo de campo em duas empresas ceramistas da cidade de Parelhas/RN, além disso, foi executada uma revisão bibliográfica a respeito da relação existente entre gestão ambiental e desempenho financeiro descritos por  pesquisadores e estudiosos da área. A análise dos resultados foi feita através de nuvens de palavras oriundas das entrevistas realizadas com os gestores das duas empresas. Os resultados sugerem que as medidas sustentáveis adotadas pelas empresas trazem melhores resultados, tanto na questão econômico-financeira, quanto na questão da imagem das instituições perante o mercado. Identificou-se que gestão ambiental promove benefícios financeiros e essas inovações indicam que realmente existe uma preocupação com o meio ambiente.
DIRECT DETERMINATION OF ERODIBILITYIN DIFFERENT FORMS OF SLOPES IN THE BELMONT STREAM BASIN IN PORTO VELHO - RONDÔNIA – BRAZIL
Authors: Santos Salem Leandro Moura dos , Filho Eliomar Pereira da Silva
Published: January 2023

This study aimed to quantify the surface erodibility (0-10cm) of oxisol in three slope morphologies in the Belmont basin Stream in Porto Velho, Rondônia – Brazil; through direct analysis using the Modified Inderbitzen equipment. The erodibility evaluation method was that of Heidemann, which considers a soil to be erodible when it obtains percentages greater than 5% of its mass disaggregation. The samples were exposed to showering in the Inderbitzen for 90 minutes at flow intensities of 3.00L/min. The erodible potential presented different values for each soil sample. The foothills of the Convex Slope - CX showed to be the most erodible of this, with a value of 14.51% of breakdown. The RectilinearSlope - RT presented the top and bottom as more erodible (12.43% and 7.8% respectively). The Concave slope - CV proved to be the most erodible slope of all analyzed, with the percentage of its surface above 20% of disaggregation. It was observed in the sample thirds that the different formats and slopes spatially influence the intensity of soil erosion in each slope third, influencing the variability of the erodible potential along the slopes.
CONTABILIDADE 4.0: AVANÇOS DA TECNOLOGIA DA INFORMAÇÃO CONTÁBIL EM UMA EMPRESA DO SETOR SUCROALCOOLEIRO/MT
Authors: Ramos Joice Karlla Alves Pereira , Servilha Graziele Oliveira Aragão , Dos Santos Josiane Silva Costa , Da Silva Roberto Weber
Published: January 2023

A contabilidade 4.0 possui características tempestiva se fazendo presente em escritórios, empresas e autônomos, acompanhando as exigências dos sistemas integrados, e as novas interfaces do fisco brasileiro. O objetivo da pesquisa foi identificar as perspectivas dos profissionais do setor fisco/contábil sobre os avanços da contabilidade nos processos de uma empresa do setor sucroalcooleira em Mato Grosso. Trata-se de um estudo descritivo, com abordagem quali-quantitativa e utilizou o método de estudo de caso e técnica de levantamento survey. O estudo identificou que 55,80% já ouviram falar de contabilidade 4.0, e que 76,70% concordam que a contabilidade 4.0 tem intuito de simplificar as atividades contábeis, e 95,30% acreditam que precisam preparar-se para novas funções focadas em análise de dados e informações. Os impactos da contabilidade 4.0 para 81,40% foram a agilidade e ganho de tempo. Identificou quanto aos desafios a falta de conhecimento e a adaptação a tecnologia e as constantes mudanças foram considerados um desafio para os profissionais. Conclui-se que as vantagens é a melhoria nos prazos de entrega e qualidade de informações, portanto precisa-se de profissionais dinâmicos e com conhecimento técnico, para tornar o trabalho eficaz e preciso.