bluuebunny/crossref_metadata_2025 huggingface dataset:
How (not) to construct worlds with responsibility
Authors: Lampert Fabio , Merlussi Pedro
Published: July 2021

In a recent article, P. Roger Turner and Justin Capes argue that no one is, or ever was, even partly morally responsible for certain world-indexed truths. Here we present our reasons for thinking that their argument is unsound: It depends on the premise that possible worlds are maximally consistent states of affairs, which is, under plausible assumptions concerning states of affairs, demonstrably false. Our argument to show this is based on Bertrand Russell’s original ‘paradox of propositions’. We should then opt for a different approach to explain world-indexed truths whose upshot is that we may be (at least partly) morally responsible for some of them. The result to the effect that there are no maximally consistent states of affairs is independently interesting though, since this notion motivates an account of the nature of possible worlds in the metaphysics of modality. We also register in this article, independently of our response to Turner and Capes, and in the spirit of Russell’s aforementioned paradox and many other versions thereof, a proof of the claim that there is no set of all true propositions one can render false.
Phylogenetic and evolutionary analysis of foot-and-mouth disease virus A/ASIA/Sea-97 lineage
Authors: Bae Soyeon , Li Vladimir , Hong Juyong , Kim Jin Nam , Kim Heebal
Published: July 2021

Foot-and-mouth disease virus (FMDV) A/ASIA/Sea-97 is a predominant lineage in Southeast Asia and East Asia. However, Sea-97 lineage has not been well studied since its first outbreak in Thailand in 1997. Thus, we conducted phylogenetic and evolutionary analysis of Sea-97 using 224 VP1 sequences of FMDV A/ASIA during 1960 and 2018. Phylogenetic analysis revealed that Sea-97 lineage can be classified into five groups (G1–G5). After the emergence of G2 from G1, the genetic diversity of Sea-97 increased sharply, causing divergence into G3, G4 and G5. During this evolutionary process, Sea-97 lineage, which was initially found only in some countries in Southeast Asia, gradually spread to East Asia. The evolution rate of this lineage was estimated to be 1.2 × 10–2 substitutions/site/year and there were many differences in amino acid residues compared to vaccine strain. Substitutions at antigenically important sites may affect the efficacy of the vaccine, suggesting the need for appropriate vaccine strains. Our results could provide meaningful information to understand comprehensive characteristic of Sea-97 lineage.
Does it pay more to be green in family firms than in non-family firms?
Authors: Garcés-Ayerbe Concepción , Rivera-Torres Pilar , Murillo-Luna Josefina L. , Suárez-Gálvez Cristina
Published: July 2021

The contradictory empirical evidence about whether the effect of companies' environmental investments on financial results is positive, negative or not significant has been explained by the different conditions and contexts that facilitate or hinder the ability to generate a win–win situation. This explanation has gradually led the academic debate to consider the factors and conditions that moderate such a relationship. In this document, we analyse the relevant but scarcely studied moderating effect of the condition of being a family firm, by integrating the socioemotional wealth (SEW) perspective into the natural-resource-based view (NRBV). Based on the analysis of panel data from 2936 Spanish manufacturing firms, covering the period 2009–2016, we offer empirical evidence showing that the financial benefits derived from environmental investment are positive and significant in family firms, while this is not so in non-family firms. Furthermore, our results show that intrinsic characteristics such as the sector, size or age of the company also condition the financial results of environmental investments.
A Longitudinal Analysis of Naturalization and International Migration in Switzerland, 2011–2017
Authors: Galeano Juan , Pont Aurélie , Wanner Philippe
Published: July 2021

The notion of residential settlement associated with the acquisition of new citizenship has been recently challenged by a number of studies highlighting its instrumentality as a subsequent mobility factor. The long and diverse history of Switzerland as a country of immigration and the availability of rich data on naturalization and international migration that allow individuals to be followed over time make this country a valuable case for investigating the impact of naturalization on international (return or onward) migration. Using longitudinal data, we follow 88,900 immigrants who entered the country between 1998 and 2000 over a period of 84 months between January 2011 and December 2017, documenting changes in naturalization status and in migratory movements and their direction. Using different implementations of a Cox proportional hazards model, we examine whether and under what conditions the international migration behaviour of naturalized persons differs from that of non-naturalized persons. Our results show that the population accessing naturalization tends to be less mobile, but also that among third-country nationals, naturalization can trigger further international mobility, in particular among those with poor economic performance and with no family ties in Switzerland.
The challenge of choosing in cardiovascular risk management
Authors: Hoogeveen R. M. , Hanssen N. M. J. , Brouwer J. R. , Mosterd A. , Tack C. J. , Kroon A. A. , de Borst G. J. , ten Berg J. , van Trier T. , van Lennep J. Roeters , Liem A. , Serné E. , Visseren F. L. J. , Cornel J. H. , Peters R. J. G. , Jukema J. W. , Stroes E. S. G. ,   the PANORAMA working group
Published: July 2021

Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. For many years guidelines have listed optimal preventive therapy. More recently, novel therapeutic options have broadened the options for state-of-the-art CV risk management (CVRM). In the majority of patients with CVD, risk lowering can be achieved by utilising standard preventive medication combined with lifestyle modifications. In a minority of patients, add-on therapies should be considered to further reduce the large residual CV risk. However, the choice of which drug combination to prescribe and in which patients has become increasingly complicated, and is dependent on both the absolute CV risk and the reason for the high risk. In this review, we discuss therapeutic decisions in CVRM, focusing on (1) the absolute CV risk of the patient and (2) the pros and cons of novel treatment options.
Enhancing Firm Performance Through Adoption of Innovation: an Empirical Evidence from Indian Biotechnological Firms
Authors: Narayan Aishwarya , Hungund Sumukh
Published: July 2021

This paper explores the influence of innovation approaches on innovation performance and firm performance among Indian biotechnology firms. Further, it aims to discuss the interceding role of innovation performance between innovation practices and firm performance. A criteria-based snowball sampling method was adopted for data collection. The collection of data was carried out using a web survey from 200 biotechnology firms located across India. The data is analysed using a covariance-based structural equation modelling (SEM) technique. The results indicate that the adoption of innovation practices positively influences the firms’ innovation and overall performance. Furthermore, the results confirm the mediating role of innovation performance between innovation approach adoption and firm performance. Firms, particularly from the biotechnology industry, can use these results to assess their performance and formulate or modify their strategy to improve their innovation and overall performance.
Establishing Background Pathologic Changes of Valve Replacement Surgery in Sheep
Authors: Faustich Jill T. Schappa , Carney John P. , Lahti Matthew T. , Zhang Benjamin L. , Bianco Richard W.
Published: July 2021

Purpose

Sheep are the standard preclinical model for assessing safety of novel replacement heart valves, yet the anatomic and pathologic effects of invasive surgery, including those involving cardiopulmonary bypass (CPB), are unknown. Thus, we aimed to determine the gross, hematologic and biochemical effects of sham mitral and aortic replacement valve procedures in sheep to establish a useful control for evaluation of novel replacement valves.

Methods

Six control sheep were examined without any surgical intervention. Six sham mitral valve replacements (MVR) and six sham aortic valve replacements (AVR) were performed on 12 sheep. Complete blood counts and serum biochemistry were performed throughout the study. Sheep were sacrificed with a necropsy performed at 90 days.

Results

Renal infarcts (RIs) were the most frequently observed lesion, averaging 4.7 in control sheep, 2.5 with MVR and 5.8 with AVR. The number of infarcts strongly correlated with total estimated area of infarcted kidney (r = .84, p < .01). Additional cardiac interventions were significantly correlated with increased numbers of RIs (r = .85, p < .01). There was no correlation between number of RIs and time on CPB, or between AVR and MVR procedures.

Conclusion

The sheep model for AVR and MVR requires invasive surgery and CPB, which are associated with background anatomic and pathologic changes, especially in cases with additional surgical cardiac interventions. These findings serve as a critical control for future evaluation and development of novel replacement valves in order to distinguish device-related safety issues from expected outcomes of the surgical procedure and normal background changes in sheep.
The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade
Authors: Sakyi Patrick O. , Amewu Richard K. , Devine Robert N. O. A. , Ismaila Emahi , Miller Whelton A. , Kwofie Samuel K.
Published: July 2021

Despite advancements in the areas of omics and chemoinformatics, potent novel biotherapeutic molecules with new modes of actions are needed for leishmaniasis. The socioeconomic burden of leishmaniasis remains alarming in endemic regions. Currently, reports from existing endemic areas such as Nepal, Iran, Brazil, India, Sudan and Afghanistan, as well as newly affected countries such as Peru, Bolivia and Somalia indicate concerns of chemoresistance to the classical antimonial treatment. As a result, effective antileishmanial agents which are safe and affordable are urgently needed. Natural products from both flora and fauna have contributed immensely to chemotherapeutics and serve as vital sources of new chemical agents. This review focuses on a systematic cross-sectional view of all characterized anti-leishmanial compounds from natural sources over the last decade. Furthermore, IC50/EC50, cytotoxicity and suggested mechanisms of action of some of these natural products are provided. The natural product classification includes alkaloids, terpenes, terpenoids, and phenolics. The plethora of reported mechanisms involve calcium channel inhibition, immunomodulation and apoptosis. Making available enriched data pertaining to bioactivity and mechanisms of natural products complement current efforts geared towards unraveling potent leishmanicides of therapeutic relevance.

Graphic Abstract
Study on the cardboard behavior during the vacuum picking process in automatic pantyhose packaging machine
Authors: Wu Shiqing , Li Peixing
Published: July 2021

This study presents a use case of Finite Element Method and comparative experimental studies on a subproblem in packaging machines. The variables in the vacuum picking system including baffle height, back pressure and friction between sheets are evaluated through simulations and experiments. It is found that baffle height, back pressure F and friction between sheets are all critical in successful operation of vacuum picking cardboards from in-feed magazine. This study is of some practical value for the implementation of vacuum picking board sheets from in-feed magazine on many types of packaging machinery.
Drug delivery systems for the photodynamic application of two photosensitizers belonging to the porphyrin family
Authors: Malacarne Miryam Chiara , Banfi Stefano , Rugiero Matteo , Caruso Enrico
Published: July 2021

Photodynamic therapy involves the concomitant action of three components, light with an appropriate wavelength, molecular oxygen, and a molecule, able to absorb an electromagnetic radiation, called photosensitizer (PS). A fundamental aspect is the bioavailability of the PS that is directly related to some physicochemical properties of the PS itself as it should feature a certain degree of lipophilicity to easily cross the cell membrane, however, at the same time, should be sufficiently water-soluble to navigate in the bloodstream. Consequently, the use of a system for drug delivery becomes essential when photosensitizers with a high degree of lipophilicity are considered. In this work, we present three different drug delivery systems, microemulsions, emulsions and liposomes all capable of carrying a PS belonging to the porphyrin family: the tetraphenyl porphyrin (TPP) and the 4-hydroxyphenyl porphyrin (THPP), which show a relevant different degree of lipophilicity. A series of microemulsions (ME) and emulsions (E) were prepared, among which two formulations, one for THPP and one for TPP, have been chosen. The stability of these two carriers was monitored over time and under various temperature conditions. With the same criteria, two liposomal formulations have been also identified and analyzed. The four formulations mentioned above (one ME, one E and two liposomes) have been tested on SKOV3 tumor cell line comparing the photodynamic activity of the porphyrin formulations versus the aqueous/organic (DMSO) solution of the same two PSs. The results show that all the formulations have proved to be excellent carriers and that the liposomal formulation enhance the photodynamic efficacy of both porphyrins.
How the COVID-19 Pandemic Affects Sexual Behavior of Hetero-, Homo-, and Bisexual Males in Germany
Authors: Mumm Jan-Niclas , Vilsmaier Theresa , Schuetz Julius M. , Rodler Severin , Zati Zehni Alaleh , Bauer Ricarda M. , Staehler Michael , Stief Christian G. , Batz Falk
Published: July 2021

Introduction

The COVID-19 pandemic drastically altered the way of life around the world. Due to social distancing measures, contact restrictions and fears of infection, social life has changed significantly. These measures along with the stressors associated with the current worldwide situation, will inevitably have an effect on people's interpersonal and personal behaviors.

Aim

This study evaluates the effect the COVID-19 pandemic and nationwide German lockdown had on the sexual behavior of cis men.

Methods

An anonymous nationwide web-based questionnaire was conducted among cis men in Germany during the first COVID-19 home isolation (April 20, 2020–July 20, 2020). The questionnaire was distributed via e-mail, online chats and social-media platforms.

Main Outcome Measures

Data was collected on general characteristics including demographics and socio-economic backgrounds. To evaluate sexual health, questions from the Sexual Behavior Questionnaire were included.

Results

523 cis male participated. 414 met the inclusion criteria. Most were heterosexual (n = 248, 59.9%; vs homosexual n = 97, 23.4%; vs bisexual n = 69, 16.7%). 243 (59%) were employed, 153 (37.1%) were students and 16 (3.9%) were unemployed. Most of the participants reported an annual income lower than 75.000€. During the lockdown, average weekly frequency of sexual intercourse and masturbation was increased in all groups. Consistently, a significant rise of higher satisfaction with the frequency of sexual contacts during the quarantine was observed (P < .05). Furthermore, the level of sexual arousal increased significantly in all groups (P < .0005). Capability to enjoy sexual intercourse or masturbation increased significantly in heterosexual (P < .0005) and homosexual men (P < .005). Bisexual participants showed a significant increase in general satisfaction with sexual life (P < .05) and a significant decrease in satisfaction in relationship or single life (P < .05). Positive confounders in the changing of sexual behavior during the COVID-19 pandemic were: Being in a relationship or being single, parenthood and being employed.

Conclusion

Our study firstly describes how COVID-19 pandemic related restrictions and social distancing measurements altered sexual behavior amongst cis male in Germany. Further studies, including sexual minorities specifically, are needed to clarify if the behavior in the first German nationwide quarantine has persisted or transformed as the pandemic proceeded. Mumm J-N, Vilsmaier T, Schuetz JM, et al. How the COVID-19 Pandemic Affects Sexual Behavior of Hetero-, Homo-, and Bisexual Males in Germany. Sex Med 2021;9:100380.
The Relationships of Dehydroepiandrosterone Sulfate, Erectile Function and General Psychological Health
Authors: Li Kanglai , Liang Shangyan , Shi Yuyan , Zhou Ying , Xie Liping , Feng Jiali , Chen Zhongcheng , Li Qingling , Gan Zhaoyu
Published: July 2021

Introduction

Dehydroepiandrosterone sulfate (DHEAS) has been reported to be associated with sexual function and general psychological health respectively, however, no one has ever examined their mutual relationships in a single study.

Aim

The aim of the present study was to find out whether DHEAS, general psychological health, and erectile function were all associated with each other.

Methods

A cross-sectional study was conducted on 34 patients with erectile dysfunction (ED) and 32 healthy controls (HC). The levels of serum DHEAS were assessed by chemiluminescence method. Erectile function and general psychological health were measured by International Index for Erectile Function-5 (IIEF-5) and General Health Questionnaire 20(GHQ-20) respectively.

Main Outcome measure

The primary outcome measure of this study was the mutual correlations of serum DHEAS levels, general psychological health and erectile function.

Results

Compared to HC, patients with ED had a significant lower serum levels of DHEAS (6.43 ± 2.70 μmol/L vs 9.48 ± 2.82 μmol/L, P < .001) and higher scores on GHQ-20 (35.06 ± 8.56 vs 24.97 ± 2.55, P < .001). Multivariate binary logistic regression showed that both serum levels of DHEAS (OR = 0.667, 95% CI = 0.512–0.869, P = .003) and psychological distress (scores of GHQ-20 > 28) (OR = 6.921, 95% CI = 1.821–26.305, P = .005) were significantly associated with ED. However, no significant association between psychological distress and serum levels of DHEAS was found (OR = 0.798, 95% CI = 0.623–1.021, P = .072) after controlling for ED. Partial correlation analysis revealed that both scores of GHQ-20 (r = −0.595, P < .001) and DHEAS (r = 0.450, P < .001) were significantly correlated with scores of IIEF-5, while no significant relationship was found between scores of GHQ-20 and DHEAS (r = 0.116, P = .363) after controlling for scores of IIEF-5 and age.

Conclusion

Both serum levels of DHEAS and general psychological health are significantly associated with erectile dysfunction in sexually active adult men but the relationship between general psychological health and erectile function seems to be independent of DHEAS.

Li K, Liang S, Shi Y, et al. The Relationships of Dehydroepiandrosterone Sulfate, Erectile Function and General Psychological Health. Sex Med 2021;9:100386.
Management of Disastrous Complications of Penile Implant Surgery
Authors: Bettocchi C. , Osmonov D. , van Renterghem K. , Djiovic R. , Ralph D.J.
Published: July 2021

Rationale

Penile Prosthesis Implantation (PPI) is the definitive treatment for Erectile Dysfunction not responsive to conservative management strategies. Furthermore, it is a staple of surgical treatment of severe Peyronie’s Disease (PD) and phallic reconstruction. Expert implantologists occasionally face disastrous complications of penile implant surgery which can prove to be very challenging. In this article we present a selected number of case reports which exemplify this kind of situations and discuss management strategies while also commenting on plausible aetiologies.

Patients’ concerns

The first case describes a PPI performed in end-stage fibrotic corpora after multiple instances of implantation/explant. The second and third cases show two diametrically opposed approaches to the management of glans necrosis after PPI in post-radical cystectomy patients. The fourth case describes the history of a diabetic patient suffering from glandular, corporal and urethral necrosis after a complicated PPI procedure. The fifth case reports the surgical treatment of a case of recurring PD due to severe scarring and shrinking of a vascular Dacron patch applied in a previous operation.

Diagnosis

Complication diagnosis in all patient was mainly clinical, intra- and postoperative, with Penile Color Doppler Ultrasonography performed when needed in order to demonstrate penile blood flow.

Interventions

The patients underwent complex surgical procedures that addressed each specific complication. Complex penile implants with fibrosis-related complications, penile prosthesis explant with and without surgical debridement of necrotic areas, penile prosthesis explant with necrotic penile shaft and urethral amputation with perineostomy, and complex corporoplasty with scar tissue excision and patch application with PPI were performed in the five patients.

Outcomes

Penile anatomy and erectile function with PPI was achieved in 4 out of 5 patients. 1 of 5 patient is scheduled to undergo a total phallic reconstruction procedure at the time of this writing.

Lessons

Management of disastrous complications of penile implant surgery can be very challenging even in expert hands. In-and-out knowledge of possible PPI and PD complications is required to achieve an acceptable outcome.
Anti-Androgenic Effects Comparison Between Cyproterone Acetate and Spironolactone in Transgender Women: A Randomized Controlled Trial
Authors: Burinkul Supanat , Panyakhamlerd Krasean , Suwan Ammarin , Tuntiviriyapun Punkavee , Wainipitapong Sorawit
Published: July 2021

Background

Spironolactone and cyproterone acetate are commonly used in feminizing hormone therapy to achieve the goal of female range testosterone level; however, the data on the efficacy comparing between these two anti-androgens are scarce.

Aim

To compare the anti-androgenic effects between spironolactone and cyproterone acetate as the component of feminizing hormone therapy among transgender women population.

Methods

The study was single-blinded randomized controlled trial involved 52 transgender women from two transgender health clinics. Each participant received oral estradiol valerate 4 mg/day combined with anti-androgen, spironolactone 100 mg/day or cyproterone acetate 25 mg/day, depending on which group they were randomized to. Clinical and biochemical variables were obtained at baseline and at 12 weeks of feminizing hormone therapy.

Main Outcome Measures

The change of testosterone level from baseline. Other changes including free testosterone, estradiol, prolactin and lipid profile after the therapy.

RESULTS

After a 12 weeks of feminizing hormone therapy, the change of testosterone level in the cyproterone acetate group [558.0 ng/dL (IQR 352.0 to 783.3)] was significantly higher than the spironolactone group [226.2 ng/dL (IQR,-4.3 to 480.1)](p value <0.001). Testosterone and calculated free testosterone in the cyproterone acetate group were significantly lower than the spironolactone group. Consequently, a proportion of the participants who achieved the female range testosterone (<50 ng/dL) was significantly higher in cyproterone acetate group (90%) compared to the spironolactone group (19%). Serious adverse effects observed in cyproterone acetate users were drug-induced liver injury and asymptomatic hyperprolactinemia.

Clinical Implications

The data on the differences between the two anti-androgen could be benefit for the transgender health-care providers in medication selection and adverse-effects counseling.

Strengths & Limitations

The study design was randomized controlled trial and controlled the estrogen component by prescribed the same type and dose for each participant. However, the study was suffered from the confound feminizing effects from previous hormone therapy and the high drop-out rate.

CONCLUSION

For feminizing hormone therapy, cyproterone acetate had a higher testosterone suppression efficacy than spironolactone.
Are the sustainability-oriented skills and competencies of business graduates meeting or missing employers’ needs? Perspectives of regional employers
Authors: McCarthy Breda , Eagle Lynne
Published: July 2021

In the Anthropocene, universities play a role in developing students’ sustainability literacy and capacity to solve socio-ecological challenges. The objective of this study is to identify the generic and sustainability-oriented skills and competencies required of business graduates by regional employers. The regional focus meets a gap in the literature. An online survey of employers in North Queensland found that they attach importance to a wide range of skills and competencies and see sustainability as a key factor in future business success. Yet, there are contradictions in terms of their support for sustainability in the curriculum and business practices, particularly when it comes to the recruitment and selection process. Furthermore, contradictions exist between the university’s adoption of the Sustainable Development Goals (SDGs), and the weak interest displayed by prospective employers in graduates’ sustainability literacy. This study has important implications for regional universities. A reframing of the role of sustainability education in the curriculum is warranted, where a deeper connection is made between sustainability education and the values employers already hold. Recommendations for curriculum designers are made on how to foster and assess the competencies that business graduates need to meet the demands of regional business upon entering the labour market.
Fair payment and just benefits to enhance diversity in clinical research
Authors: Bierer Barbara E. , White Sarah A. , Gelinas Luke , Strauss David H.
Published: July 2021

Routine, nonmedical and ancillary medical costs associated with participation in clinical research create barriers to enrollment for economically disadvantaged individuals. To the extent that race, ethnicity, and gender are linked to SES, such barriers impact efforts to diversify clinical research enrollment. But payment policies and practices often reflect the longstanding and singular concern that payment to participants will bias decision-making and compromise informed consent. We argue that this concern must be viewed in a larger ethical context in which the untoward consequences for the individual participant and for the broader research enterprise are considerable when either inadequate or no payment is provided for expenses incurred (“reimbursement”) and time committed (“compensation”). Fairness in payment and protection from undue influence of payment on the informed consent process are important but distinct ethical considerations. Fundamentally, approaches to payment that leave participants financially worse off as a consequence of taking part in research are inherently unjust as they have a differential impact on recruitment and retention based on socioeconomic status. Sponsors, funders, investigators, and IRBs must be cognizant of the impact of inadequate payment on clinical trial inclusion of historically understudied groups. We address practical and fair payment strategies to advance inclusion, the additional barrier of ancillary medical costs, and potential unintended consequences of payment.
High-energy, high-repetition-rate ultraviolet pulses from an efficiency-enhanced, frequency-tripled laser
Authors: Lü Xinlin , Peng Yujie , Wang Wenyu , Zhao Yuanan , Zhu Xiangyu , Leng Yuxin
Published: July 2021

In this study, a high-energy, temporally shaped picosecond ultraviolet (UV) laser running at 100 Hz is demonstrated, with its pulses boosted to 120 mJ by cascaded regenerative and double-pass amplifiers, resulting in a gain of more than 108. With precise manipulation and optimization, the amplified laser pulses were flat-top in the temporal and spatial domains to maintain high filling factors, which significantly improved the conversion efficiency of the subsequent third harmonic generation (THG). Finally, 91 mJ, 470 ps pulses were obtained at 355 nm, corresponding to a conversion efficiency as high as 76%, which, as far as we are aware of, is the highest THG efficiency for a high-repetition-rate picosecond laser. In addition, the energy stability of the UV laser is better than 1.07% (root mean square), which makes this laser an attractive source for a variety of fields including laser conditioning and micro-fabrication.
Following the logic behind biological interpretations of the Ediacaran biotas
Authors: Runnegar Bruce
Published: July 2021

For almost 150 years, megascopic structures in siliciclastic sequences of terminal Precambrian age have been frustratingly difficult to characterize and classify. As with all other areas of human knowledge, progress with exploration, documentation and understanding is growing at an exponential rate. Nevertheless, there is much to be learned from following the evolution of the logic behind the biological interpretations of these enigmatic fossils. Here, I review the history of discovery as well as some long-established core members of widely recognized clades that are still difficult to graft on to the tree of life. These ‘orphan plesions’ occupy roles that were once held by famous former Problematica, such as archaeocyaths, graptolites and rudist bivalves. In some of those cases, taxonomic enlightenment was brought about by the discovery of new characters; in others it required a better knowledge of their living counterparts. Can we use these approaches to rescue the Ediacaran orphans? Five taxa that are examined in this context are Arborea (Arboreomorpha), Dickinsonia (Dickinsoniomorpha), Pteridinium plus Ernietta (Erniettomorpha) and Kimberella (Bilateria?). With the possible exception of Dickinsonia, all of these organisms may be coelenterate grade eumetazoans.
Topology-informed information dynamics modeling in cyber–physical–social system networks
Authors: Wang Yan
Published: July 2021

Cyber–physical–social systems (CPSS) are physical devices that are embedded in human society and possess highly integrated functionalities of sensing, computing, communication, and control. CPSS rely on their intense collaboration and information sharing through networks to be functioning. In this paper, topology-informed network information dynamics models are proposed to characterize the evolution of information processing capabilities of CPSS nodes in networks. The models are based on a mesoscale probabilistic graph model, where the sensing and computing capabilities of the nodes are captured as the probabilities of correct predictions. A topology-informed vector autoregression model and a latent variable vector autoregression model are proposed to model the correlations between prediction capabilities of nodes as linear functional relationships. A hybrid Gaussian process regression model is also developed to capture both the nonlinear spatial and temporal correlations between nodes. The new information dynamics models are demonstrated and tested with a simulator of CPSS networks. The results show that the topological information of networks can improve the efficiency in constructing the time series models. The network topology also has influences on the prediction capabilities of CPSS.
911 EMS Activations by Pregnant Patients in Maryland (USA) during the COVID-19 Pandemic
Authors: Hadley Megan E. , Vaught Arthur J. , Margolis Asa M. , Chizmar Timothy P. , Alemayehu Teferra , Halscott Torre , Jenkins J. Lee , Levy Matthew J.
Published: July 2021

Introduction:

In the early phase of the coronavirus disease 2019 (COVID-19) pandemic, United States Emergency Medical Services (EMS) experienced a decrease in calls, and at the same time, an increase in out-of-hospital deaths. This finding led to a concern for the implications of potential delays in care for the obstetric population.

Hypothesis/Problem:

This study examines the impact of the pandemic on prehospital care amongst pregnant women.

Methods:

A retrospective observational study was conducted comparing obstetric-related EMS activations in Maryland (USA) during the pandemic (March 10-July 20, 2020) to a pre-pandemic period (March 10-July 20, 2019). Comparative analysis was used to analyze the difference in frequency and acuity of calls between the two periods.

Results:

There were fewer obstetric-related EMS encounters during the pandemic compared to the year prior (daily average during the pandemic 12.5 [SD = 3.8] versus 14.6 [SD = 4.1] pre-pandemic; P <.001), although the percent of total female encounters remained unchanged (1.6% in 2020 versus 1.5% in 2019; P = .091). Key indicators of maternal status were not significantly different between the two periods. African-American women represented a disproportionately high percentage of obstetric-related activations (36.2% in 2019 and 34.8% in 2020).

Conclusions:

In this state-wide analysis of EMS calls in Maryland early in the pandemic, no significant differences existed in the utilization of EMS by pregnant women. Prehospital EMS activations amongst pregnant women in Maryland only decreased slightly without an increase in acuity. Of note, over-representation by African-American women compared to population statistics raises concern for broader systemic differences in access to obstetric care.
Poverty by Design: The Role of Charity and the Cultivated Ethical Citizen
Authors: Parsell Cameron , Clarke Andrew , Perales Francisco
Published: July 2021

Across numerous countries with advanced welfare states, governments have relied on a hybrid of publicly funded and delivered welfare services and voluntary charity to meet the needs of people in poverty. Driven by austerity and economic downturns, many scholars agree that governments are increasingly relying on charity as a response to poverty. Taking Australia as a case study, this article demonstrates how the decayed welfare state is not just about outsourcing welfare provision to charities, but also a part of a broader project to cultivate a society in which social problems are responded to through spontaneous, community-led initiatives, powered by the ethical commitment of everyday citizens. We show how this project produces poverty through welfare state retrenchment, whilst simultaneously cultivating charity through material and symbolic support from the state. This results in the construction of charity as an end in itself, with little consideration given to its effectiveness in alleviating poverty.
Effectiveness of glufosinate, dicamba, and clethodim on glyphosate-resistant and -susceptible populations of five key weeds in Australian cotton systems
Authors: Werth Jeff , Thornby David , Keenan Michelle , Hereward James , Chauhan Bhagirath Singh
Published: July 2021

XtendFlexTM cotton with resistance to glyphosate, glufosinate, and dicamba may become available in Australia. Resistance to these herbicides enables two additional modes of action to be applied in crop. The double-knock strategy, typically glyphosate followed by paraquat, has been a successful tactic for control of glyphosate-resistant cotton in fallow situations in Australia. Glufosinate is a contact herbicide and may be useful as the second herbicide in a double knock for use in XtendFlexTM cotton crops. We tested the effectiveness of glufosinate applied at intervals of 1, 3, 7, and 10 d after initial applications of glyphosate, dicamba, clethodim, and glyphosate mixtures with dicamba or clethodim on glyphosate-resistant and glyphosate-susceptible populations of flaxleaf fleabane, common sowthistle, feather fingergrass, windmill grass, and junglerice. Effective treatments for flaxleaf fleabane with 100% control were dicamba and glyphosate+dicamba followed by glufosinate independent of the interval between applications. Common sowthistle was effectively controlled in Experiment 1 by all treatments. However, in Experiment 2, effective treatments were dicamba and glyphosate+dicamba followed by glufosinate (99.3% to 100% control). Timing of the follow-up glufosinate did not affect the control achieved. Consistent control of feather fingergrass was achieved with glyphosate, clethodim, or glyphosate+clethodim followed by glufosinate at 7-d and 10-d intervals (99.7% to 100% control). Control of feather fingergrass was inconsistent. The best treatment for windmill grass was glyphosate+clethodim followed by glufosinate 10 d later (99.8% to 100% control). Junglerice was effectively controlled with all treatments except for glyphosate on the glyphosate-resistant population. Additional in-crop use of glufosinate and dicamba should be beneficial for weed management in XtendFlexTM cotton crops, when using the double knock tactic with glufosinate. For effective herbicide resistance management, it is important that these herbicides be used in addition to, rather than substitution for, existing weed management tactics.
Onset Altitudes of Co‐Seismic Ionospheric Disturbances Determined by Multiple Distributions of GNSS TEC After the Foreshock of the 2011 Tohoku Earthquake on March 9, 2011
Authors: Kakinami Yoshihiro , Saito Hiroaki , Yamamoto Tetsuo , Chen Chia‐Hung , Yamamoto Masa‐yuki , Nakajima Kensuke , Liu Jann‐Yenq , Watanabe Shigeto
Published: July 2021

We investigate ionospheric disturbances using the total electron content (TEC) data obtained from the radio signals emitted from three satellites after the foreshock of the 2011 Tohoku Earthquake on March 9, 2011. Co‐seismic ionospheric disturbances (CIDs) appeared to extend from an onset point concentrically in all of the satellite data. We have found, however, that the geographic coordinates of the onset points did not coincide if the observed CIDs were assumed to occur at one altitude. Admitting that the altitudes of the onset points are different, we searched for coinciding geographic coordinates of the onset points by changing the altitudes and identified the altitude of the three onset points to be 107.8, 131.8, and 133.3 km and the onset time at these altitudes. As a result, the vertical velocity of an acoustic‐gravity wave is estimated to be 448 m/s from the travel time between the altitudes of 107.8 and 131.8 km and 370 m/s between the altitude of 107.8 and 133.3 km. This is comparable to the speed of sound calculated using the empirical model NRLMSISE‐00. The present study provides a method of determining the altitude and geographic coordinates of the onset point from the ionospheric TEC analysis independently of the seismic data. Furthermore, the source location of the acoustic‐gravity wave is simultaneously determined because its wavefront propagating vertically arrives earliest at an altitude that TEC disturbance is detectable.
An Analytical Model With a Generalized Nonlinear Water Transfer Term for the Flow in Dual‐Porosity Media Induced by Constant‐Rate Pumping in a Leaky Fractured Aquifer
Authors: Lin Ye‐Chen , Yeh Hund‐Der
Published: July 2021

In the past, many mathematical models based on the dual‐porosity (DP) concept were developed to describe the groundwater flow in fractured aquifer systems. Most of them seemingly have problems in predicting accurate drawdown at the early and/or intermediate times as compared with field measured data. Thus, this study proposes a new analytical model with a generalized transfer term (GTT) to describe the flow induced by pumping in such systems. The new model is nonlinear because the GTT representing the matrix‐to‐fracture flux gives different weights to the fracture and matrix drawdowns. The GTT reduces to the existing first‐order transfer term if the weight equals zero and second‐order term if the weight is one. The present model also includes a leakage term accounting for flow from the overlain or underlain aquitard. The drawdown solution of the model is developed based on the Laplace transform method and integration by parts formula and then verified through the comparison with the finite‐element solution. The effect of different weight values in the GTT on the DP flow is investigated. Additionally, the sensitivity analysis is performed to assess the impact of the change in each of the aquifer parameters on the flow. Furthermore, the present solution is used to analyze two sets of pumping drawdown data from test sites in Canada and India. We found that the drawdown predictions from the present solution fit field measured data very well, suggesting that the present model can adequately describe the real‐world DP flow system.
Glaciological Monitoring Using the Sun as a Radio Source for Echo Detection
Authors: Peters S. T. , Schroeder D. M. , Chu W. , Castelletti D. , Haynes M. S. , Christoffersen P. , Romero‐Wolf A.
Published: July 2021

Ice‐penetrating radar observations are critical for projecting ice‐sheet contribution to sea‐level rise; however, these prognostic models have significant uncertainties due to an incomplete understanding of glacial subsurface processes. Existing radars that can characterize subsurface conditions are too resource‐intensive to simultaneously monitor ice sheets at both the necessary temporal—daily to multiannual—and spatial—tributary to continental—scales. Here, we investigate using an ambient radio source, instead of transmitting a signal, for glaciological monitoring. We demonstrate, for the first time, passive radio sounding using the Sun to accurately measure ice thickness on Store Glacier, Greenland. Passive radar sounding could provide low‐resource time‐series measurements of the cryosphere, enabling us to observe and understand evolving englacial and subglacial conditions across Greenland and Antarctica with unprecedented coverage and resolution.
The High‐Latitude Extension of Jupiter's Io Torus: Electron Densities Measured by Juno Waves
Authors: Elliott S. S. , Sulaiman A. H. , Kurth W. S. , Faden J. , Allegrini F. , Valek P. , Connerney J. E. P. , Ebert R. W. , Szalay J. R. , Bagenal F. , Bolton S. J.
Published: July 2021

We present Jovian electron densities measured by the Juno Waves instrument at high‐latitudes (with magnetic latitudes of on magnetic field lines threading the Io torus and plasma sheet (with M‐shells of ) using the first 29 orbits of the Juno mission. We infer electron densities from characteristic frequency cutoffs and resonances in plasma wave spectra. Often more than one of the characteristic frequencies of the plasma can be identified, whose consistency provides credibility to the plasma density estimates. The majority of density measurements are on magnetic field lines threading the Io torus and intersecting Jupiter's ionosphere between Io's M‐shell and the auroral main oval, but there is evidence of density dropouts near and poleward of the auroral oval, which may be important in auroral particle acceleration. Sharp density gradients are found near field lines mapping to the inner edge of the Io torus M‐shells. These observations demonstrate the extension of elevated Io torus densities along field lines to higher latitudes.
Freshwater Lens Fronts Propagating as Buoyant Gravity Currents in the Equatorial Indian Ocean
Authors: Moulin Aurélie J. , Moum James N. , Shroyer Emily L. , Hoecker‐Martínez Martín
Published: July 2021

Freshwater lenses (FWLs) deposited by rain exhibit local anomalies in surface salinity and temperature. The resulting patchiness in near‐surface density and sea surface temperature influence upper ocean dynamics and air‐sea fluxes of heat. Understanding lens formation and evolution has been a focus of recent observational and modeling efforts. The work presented here integrates near‐surface ocean and atmosphere time series with remote sensing of sea surface disturbances (X‐band radar) to describe properties and kinematics of FWLs in the equatorial Indian Ocean. Twenty‐eight FWLs were observed with diverse temperature‐salinity properties and structure. Fresh salinity anomalies were as large as −1.35 psu at 3 m depth. Associated temperature anomalies ranged from −0.80 to +0.59°C. Ship‐based radar imagery allowed quantification of propagation speeds of 10 FWL fronts. In the reference frame of the moving fluid, the observed speeds are consistent with the linear long wave speed of . These results offer a novel perspective on the evolution of FWLs as gravity currents whose dynamics need to be properly accounted for to assess lens longevity, including persistence of salinity and temperature anomalies, as well as influences on air‐sea interaction.
Observation of Gravity Waves at the Tropical Tropopause Using Superpressure Balloons
Authors: Corcos Milena , Hertzog Albert , Plougonven Riwal , Podglajen Aurélien
Published: July 2021

Tropical gravity wave activity is investigated using measurements of momentum fluxes gathered during Strateole‐2 superpressure balloon flights. The data set consists of eight balloon flights performed in the deep tropics from November 2019 to February 2020. The flights lasted for 2–3 months each, and in‐situ meteorological data were collected every 30 s. The relation between gravity waves and deep convection is investigated using geostationary satellite data from the NOAA/NCEP GPM_MERGIR satellite data product, at 1 h resolution. The amplitude of gravity wave momentum fluxes shows a clear dependence on the distance to the nearest convective system, with a strong decay as distance to convection increases. The largest momentum‐flux values (>mPa) are only found less than 200 km away from deep convection. The sensitivity of the wave flux to distance from convection is stronger for high frequency gravity waves (periods shorter than 60 min). Lower frequency waves tend to a non‐zero, background value away from convection, supporting some background value in gravity‐wave drag parameterizations. On the other hand, the wide range of momentum flux values observed close to the convection emphasizes the intermittent nature of the gravity‐wave source. The large scale variation of gravity‐wave intermittency within the equatorial belt is also studied. The results highlight spatial variations of gravity wave activity, with the highest momentum flux recorded over land.
Non-genetic photoacoustic stimulation of single neurons by a tapered fiber optoacoustic emitter
Authors: Shi Linli , Jiang Ying , Fernandez Fernando R. , Chen Guo , Lan Lu , Man Heng-Ye , White John A. , Cheng Ji-Xin , Yang Chen
Published: July 2021

Neuromodulation at high spatial resolution poses great significance in advancing fundamental knowledge in the field of neuroscience and offering novel clinical treatments. Here, we developed a tapered fiber optoacoustic emitter (TFOE) generating an ultrasound field with a high spatial precision of 39.6 µm, enabling optoacoustic activation of single neurons or subcellular structures, such as axons and dendrites. Temporally, a single acoustic pulse of sub-microsecond converted by the TFOE from a single laser pulse of 3 ns is shown as the shortest acoustic stimuli so far for successful neuron activation. The precise ultrasound generated by the TFOE enabled the integration of the optoacoustic stimulation with highly stable patch-clamp recording on single neurons. Direct measurements of the electrical response of single neurons to acoustic stimulation, which is difficult for conventional ultrasound stimulation, have been demonstrated. By coupling TFOE with ex vivo brain slice electrophysiology, we unveil cell-type-specific responses of excitatory and inhibitory neurons to acoustic stimulation. These results demonstrate that TFOE is a non-genetic single-cell and sub-cellular modulation technology, which could shed new insights into the mechanism of ultrasound neurostimulation.