bluuebunny/crossref_metadata_2025 huggingface dataset:
Longitudinal Change in Serum Neurofilament Light Chain in Type 2 Diabetes and Early Diabetic Polyneuropathy: ADDITION-Denmark
Authors: Määttä Laura L. , Andersen Signe T. , Parkner Tina , Hviid Claus V.B. , Bjerg Lasse , Kural Mustafa A. , Charles Morten , Søndergaard Esben , Kuhle Jens , Tankisi Hatice , Witte Daniel R. , Jensen Troels S.
Published: March 2024

OBJECTIVE

To investigate the longitudinal development of neurofilament light chain (NfL) levels in type 2 diabetes with and without diabetic polyneuropathy (+/−DPN) and to explore the predictive potential of NfL as a biomarker for DPN.

RESEARCH DESIGN AND METHODS

We performed retrospective longitudinal case-control analysis of data from 178 participants of the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care-Denmark (ADDITION-Denmark) cohort of people with screen-detected type 2 diabetes. Biobank samples acquired at the ADDITION-Denmark 5- and 10-year follow-ups were analyzed for serum NfL (s-NfL) using single-molecule array, and the results were compared with established reference material to obtain NfL z-scores. DPN was diagnosed according to Toronto criteria for confirmed DPN at the 10-year follow-up.

RESULTS

s-NfL increased over time in +DPN (N = 39) and −DPN participants (N = 139) at levels above normal age-induced s-NfL increase. Longitudinal s-NfL change was greater in +DPN than in −DPN participants (17.4% [95% CI 4.3; 32.2] or 0.31 SD [95% CI 0.03; 0.60] higher s-NfL or NfL z-score increase in +DPN compared with −DPN). s-NfL at the 5-year follow-up was positively associated with nerve conduction studies at the 10-year follow-up (P = 0.02 to <0.001), but not with DPN risk. Areas under the curve (AUCs) for s-NfL were not inferior to AUCs for the Michigan Neuropathy Screening Instrument questionnaire score or vibration detection thresholds. Higher yearly s-NfL increase was associated with higher DPN risk (odds ratio 1.36 [95% CI 1.08; 1.71] per 1 ng/L/year).

CONCLUSIONS

Our findings suggest that preceding s-NfL trajectories differ slightly between those with and without DPN and imply a possible biomarker value of s-NfL trajectories in DPN.
Professional Cleaners’ and Healthcare Workers’ Ability to Recognize Hand Eczema
Authors: Glenn Ullum Anna , Barati Sedeh Farnam , Jemec Gregor B.E. , Ibler Kristina Sophie
Published: March 2024

Timely intervention reduces the risk of a poor prognosis in hand eczema, making early recognition of symptoms important in high-risk professions. However, limited data exist regarding the ability of cleaners and healthcare workers to recognize hand eczema. The aim of this study was to examine cleaners’ and healthcare workers’ ability to recognize hand eczema in clinical photographs and to assess the severity of the disease. Cleaners and healthcare workers completed a questionnaire consisting of 16 questions and participated in a structured interview referring to a validated photographic severity guide for chronic hand eczema, which comprised clinical photographs of hand eczema at varying levels of severity. Eighty cleaners and 201 healthcare workers (total N = 281) participated in the study. The rates of correctly identified hand eczema in clinical photographs (cleaners/ healthcare workers) were: 41.2%/57.7% (mild hand eczema), 81.2%/92.0% (moderate hand eczema), 85.0%/94.5% (severe hand eczema) and 82.5%/97.0% (very severe hand eczema). The proficiency of healthcare workers in recognizing hand eczema was significantly higher than that of cleaners. The results indicate that a large proportion of cleaners and healthcare workers fail to recognize mild hand eczema in clinical photographs. Healthcare workers had higher success rates in recognizing hand eczema in all severity categories. Symptom underestimation may lead to under-reporting of the true prevalence of hand eczema, with consequent loss of opportunities for prevention.
Forestillinger om de andre i norske landinformasjonsdokumenter
Authors: Sørsveen Aurora Terjesdatter
Published: March 2024

Country-of-origin information is an important assessment tool in asylum administration and determination, relied on by caseworkers as well as courts in questions regarding asylum claims. Credibility is especially paramount in asylum assessments. Therefore, country-of-origin information and documents need to capture a holistic picture of conditions in asylum seekers’ countries in order for caseworkers to make informed decisions in their evaluations, and asylum-seekers’ situations are accurately portrayed. However, prior research has found that the preparation of country-of-origin information tends to reinforce an established asymmetry in asylum administration whereby lived experiences are weighted less than verifiable information (Van der Kist & Rosset, 2020). Using a practice-oriented document analysis and postcolonial theory, this chapter explores how country-of-origin information documents describe various aspects of Afghan society, and the notions of young Afghans that emerge as a result. Furthermore, the chapter investigates how these are entangled with previous colonial logic and political discourses in contemporary Norway connected to unaccompanied minors seeking asylum.
På vei inn i norskheten – gradvise skoleoverganger for ungdom med kort botid i Norge
Authors: Engan Laila , Ramirez Carla
Published: March 2024

This chapter explores experiences of school transitions for newly arrived migrant youth in Norway by focusing on one young refugee (Amal) and her experience of school transitions. Leaning on theoretical perspectives on transitions (Ecclestone, Biesta, & Hughes, 2010; Strand, 2020), funds of knowledge and funds of identity (Esteban-Guitart, 2012) and theorizations on limits to Norwegianness (Gullestad, 2002a), we depict how transitions in Norwegian school can both open and close possibilities for inclusion and belonging. Through analysis we discuss how Amal’s funds of identity are a resource in classes with other newly arrived students. At the same time, we reveal invisible cultural fences that are hard to overcome in Amal’s transition to becoming a regular student in Norwegian upper secondary school.
Betydning av materialitet for tilhørighet til Norge
Authors: Ramirez Carla
Published: March 2024

This chapter emphasizes the importance of materiality in processes of belonging. Leaning on Karen Barad’s (2007) theory of agential realism, I draw on conversations with ethnic minority youth and the ways in which they highlight things, memories, places, and moods in articulating connections to the Norwegian society. Delving into theoretical concepts of situated knowledge (Barad, 2007; Haraway, 1998) and hauntology (Barad, 2017, 2019), this article analyses how materiality enacts transformation by mixing old and new knowledge, scrutinizing how the past connects to the present in creating intercultural belongings. Explorations of ethnic minority youths’ material and situated knowledge, and the creation of new entanglements and belongings are at the core of this chapter. Human agency is distributed to embrace the importance of things, memories, affects and the past, decentering agency and belonging to include non-human and more-than-human materiality.
PENERAPAN MODEL PEMBELAJARAN GAMES BASED LEARNING UNTUK MENINGKATKAN KEMAMPUAN LITERASI DAN NUMERASI SISWA
Authors: W. Wulandari  , A.T. Widiansyah
Published: March 2024

Kemampuan literasi dan numerasi wajib untuk dimiliki peserta didik sekolah dasar. Kemampuan ini bagian dari kemampuan seseorang dalam menggunakan penalaran. Tujuan dari penelitian ini yaitu meningkatkan kemampuan literasi dan numerasi peserta didik di SD Negeri 2 Buduran melalui penerapan model pembelajaran Games Based Learning. Metode yang digunakan pada penelitian ini berupa Penelitian Tindakan Kelas (PTK) dengan menggunakan desain penelitian model Stephen Kemmis dan Mc. Taggart melalui 1 siklus pembelajaran. Hasil penerapan penelitian ini pada numerasi pre-test masih belum ada yang lulus dan pada post-test sudah mencapai 60%. Sedangkan literasi menujukan pre-test masih belum ada yang lulus dan pada post-test mencapai 67%. Simpulan pada penelitian ini menunjukan bahwa penerapan Game based learning mampu meningkatkan kemampuan literasi dan numerasi siswa di SD Negeri 2 Buduran.
PENGARUH MODEL PEMBELAJARAN INKUIRI TERBIMBING BERBANTUAN PHET TERHADAP KEMAMPUAN BERPIKIR KRITIS PESERTA DIDIK
Authors: Ismawati  , P. Yasa  , D.O. Rachmawati
Published: March 2024

Tujuan penelitian ini untuk mendeskripsikan perbedaan kemampuan berpikir kritis antara peserta didik yang belajar menggunakan model inkuiri terbimbing berbantuan PhET dengan model DI. Jenis penelitian ini adalah eksperimen semu dengan desain penelitian one way pretest-posttest non-equivalent control group design. Populasi penelitian ini adalah peserta didik kelas XI di SMA Negeri 1 Seririt sebanyak 151. Sampel penelitian menggunakan teknik simple randomize dan 2 kelas sampel penelitian dengan total sampel 76. Data kemampuan berpikir kritis diukur menggunakan instrumen berbentuk tes esai dengan reliabilitas sebesar 0,701 dan konsistensi internal tes bergerak pada 0,31-0,71. Data dianalisis dengan analisis deskriptif, analisis kovarian dan uji lanjut LSD dengan taraf signifikansi 5%. Hasil penelitian ini menunjukkan bahwa: (1) Kelompok dengan model  inkuiri terbimbing-PhET memperoleh nilai rata-rata posttest sebesar 76,00 (SD = 7,10), sedangkan kelompok dengan model DI sebesar 49,01 (SD = 13,4). Hasil uji ANAKOVA menunjukkan bahwa terdapat perbedaan kemampuan berpikir kritis antara peserta didik yang belajar dengan model inkuri terbimbing-PhET dengan peserta didik yang belajar menggunakan model DI dengan nilai signifikansi 0,001.  (2) Hasil uji LSD diperoleh bahwa * = 26,768 lebih besar dari nilai LSD hitung yang besarnya 7,91, sehingga model pembelajaran inkuiri terbimbing berbantuan PhET berpengaruh relatif lebih baik terhadap kemampuan berpikir kritis peserta didik dibandingkan dengan model pembelajaran DI. Simpulan hasil penelitian ini adalah  terdapat perbedaan signifikan kemampuan berpikir kritis antara peserta didik yang belajar dengan model inkuri terbimbing-PhET dengan peserta didik yang belajar menggunakan model DI dengan taraf signifikansi 0,05.
Effectiveness of Agricultural Information Disseminated Through Mobile Apps and Social Media
Authors: Madhushekar B. Raja , Rani V. Sudha , Padmaveni C. , Reddy M. Malla , Kumar B. Anil
Published: March 2024

The present investigation was conducted during June, 2021 to February, 2022 in twelve villages under DAATTC, six each in Bhuvanagiri and Jangaon districts, Telangana, India on the use of social media as a source of agricultural information, use pattern, preference, purpose, ranking of different social media used, information processing and its effectiveness among farmers. Social media emerged as highly powerful tools in facilitating online social interactions and has shown tremendous potential in facilitating information exchange among individuals. These tools are meant for digital communication helping in interaction among a group of people. The data were collected from farmers of Bhuvanagiri and Jangaon districts, with a sample size of 120 respondents through a structured interview schedule. 84.16% of the farmers used social media platforms for getting agriculture related information, the most preferred social media were WhatsApp, Youtube and Facebook. Garrett ranking analysis revealed that information seeking was the most preferred purpose of social media use among farmers followed by chatting/connecting with peers and watching agricultural videos. 54.17% of the farmers preserved this information obtained from social media for future use. 45.00% of them discussed this information with progressive farmers and 42.50% of them discussed with friends. 72.50% of the respondents had enhanced knowledge about pest and diseases. The personal variable of the respondents’ such as education, farm-size, scientific orientation, social participation, income, innovativeness and information seeking behaviour were significant and positively correlated (at 0.01% level of probability) with social media use.
Theoretical, methodological and practical contributions for the globalization of Chinese social sciences
Authors: Chang Xiangqun
Published: March 2024

With slight revision based on the published Preface of China and the Shared Human Future: Exploring Common Values and Goals (Volume 6 of the Globalization of Chinese Social Sciences series) by Martin Albrow, edited by Xiangqun Chang. London: Global Century Press, 2022. The first part of it is adapted from the Postscript of the Chinese edition of China’s Role in a Shared Human Future: Towards Theory for Global Leadership (Volume 4 of the Globalization of Chinese Social Sciences series) by Martin Albrow, Global Century Press, 2018.
Validity and Reliability of Higher Order Thinking Test Instrument Development Skills: systematic literature reviews
Authors: Sudarma Teguh Febri , Irfandi Irfandi , Festiyed Festiyed , Adha Yuni , Yerimadesi Yerimadesi
Published: March 2024

Higher Order Thinking Skill (HOTS) is the ability to think that does not simply recall, restate, or refer without reciting. HOTS questions in the context of assessment measure the ability to transfer one concept to another, process and apply information, find links from various information, use the information to solve problems, and critically examine ideas and information. In this study, 17 articles were used, which included 14 national articles and 3 international articles. The seventeen articles discussed the development of the Higher Order Thinking Skill Test Instrument Development instrument. The test instrument developed contains Higher Order Thinking Skills. Based on the results of the meta-analysis research, it can be concluded that the validity value of the seventeen journals is 1.85 with a high category. The reliability value is 0.615 to 0.94 with a high category. Development based on the level of study is still piled up at the junior and senior high school levels
Development of Student Worksheet Based on Guided Inquiry Using Articulate Storyline in Fungi Subject Matter for Tenth Grade at SMAN 2 Plus Panyabungan
Authors: Nst Fitri Afifah , Gultom Endang Sulistyarini
Published: March 2024

This study aims to determine the feasibility of worksheets based on guided inquiry using Articulate storyline on fungi material. This study uses the ADDIE development model which consists of five steps, namely analysis, design, development, implementation, and evaluation. The results showed that teachers and students needed worksheet so that the worksheet  was designed based on guided inquiry. The validation of material experts, learning experts, and design experts are in the very good category with an average score of 96.87%, 96.87%, and 88.46%. The biology teacher's assessment obtained an average of 98.4% which was included in the very good category, and the student response to the worksheet obtained an average of 96.07% which was included in the good category. The product developed is effective in achieving learning indicators on fungi subject matter in terms of the N-gain test with a medium category of 0.65%. So, it can be concluded that worksheet is suitable for use in the learning process.
STUDENTS' HIGHER ORDER THINKING SKILLS AND SELF REGULATED LEARNING ON GENERAL BIOLOGY COURSE OF FIRST SCIENCE STUDENTS' OF FMIPA UNIVERSITAS NEGERI MEDAN
Authors: Nurjannah Lisa , Hasruddin Hasruddin
Published: March 2024

ABSTRACTThe aims of the study are to determine the application of higher order thinking skills and student self-regulated learning in the General Biology Course, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan. This research was conducted in the departments of Mathematics, Physics, Biology, Chemistry, Science and Computer Science. Sampling was done by random sampling, by taking 6 classes from different majors. The type of this research is descriptive-quantitative research. The number of higher order thinking skills tests was 15 items and self-regulated learning tests were 40 items. The test is validated first before being used as a research instrument, followed by a validity test of the instrument, a reliability test, a test of the level of difficulty and distinguishing power. The results showed that the application of students' higher-order thinking skills in the General Biology course at the Faculty of Mathematics and Natural Sciences was still in the low category. This can be seen from the results of the Mathematics Education class B, as much as 3% is in the perfect category, 28% is in the very good category, 7% is in the good category, and 60% is in the low category. In Physics Education class A, 38% are in the Perfect category, 38% are in the very good category, and 23% are in the low category. In the Biology A education class, 30% are in the perfect category, 5% are in the good category, and 65% are in the low category. In the Non-educational Chemistry class A, 28% were in the Perfect category, 17% were in the very good category, and 50% were in the low category. In IPA B class, 14% are in the perfect category, 28% are in the very good category, and 57% are in the low category. In computer science class C, 17% are in the perfect category, 33% are in the good category, and 50% are in the low category. Meanwhile, Self-Regulated Learning for Students of the Faculty of Mathematics and Natural Sciences in the General Biology course is included in good categories, this is because the application of the KKNI curriculum accustoms students to be able to study independently through the assignment of six compulsory assignments for students. Keyword: higher order thinking skills, self regulated learning, general biology.
ANALYSIS OF THE IMPLEMENTATION OF BIOLOGY PRACTICUM AND ITS RELATIONSHIP WITH STUDENT HIGHER ORDER THINKING SKILLS AND LEARNING OUTCOMES
Authors: Alfaraby Muhammad , Sipahutar Herbert
Published: March 2024

This study aims to find out whether the implementation of biology practicum has a relationship with higher-order thinking skills and learning outcomes of class XI IPA students of SMA Negeri 3 Tanjung Balai in the academic year 2021/2022. All students of class XI IPA, totaling 137 students, were used as research samples. The research instrumentswere consisted of a questionnaire (for practicum implementation), an essay test(for higher- order thinking skills), and a multiple choice test(for student learning outcomes). The data were analyzed in a quantitative descriptive manner by presenting the answers of the respondents regarding the research on implementing practices, higher order thinking skills, and student learning outcomes. The results of this study indicate that the implementation of biology practicum is included in the good category with a percentage of 77%. Students' high-order thinking skills in biology learning are included in the good category with a percentage of 78%, and student learning outcomes in biology learning are included in the good category with a percentage of 76%. This also meets the KKM standard (Minimum Completeness Criteria).
ANALYSIS OF METACOGNITIVE AWARENESS OF PROSPECTIVE BIOLOGY TEACHER STUDENTS THROUGH CREATIVE WRITING BULLET JOURNALING
Authors: Arwita Widya , Nasution Aswarina , Sihite Onggal
Published: March 2024

Class of 2020 students face practical lectures such as Real Work Lectures and Introduction to the School Field as well as preparation for the final Thesis assignment. These lectures are not specifically scheduled in the study program, but are related to the partners where the students practice. This is a challenge for students in managing time and independence in carrying out academic activities. The ability to manage time, plan activities and carry out evaluations are metacognitive aspects needed by students. Therefore, this research aims to analyze students' metacognitive awareness through creative bullet journaling writing. The research population was all students of the Class of 2020 biology education at Medan State University who were taking KKN & PLP courses. The sample consisted of 30 students taken randomly. The data collection technique is carried out by providing bullet journaling before the new semester begins. Then students are given time to fill in the journal for approximately 3 months. Data analysis was carried out descriptively quantitatively. The research results show that students have classical metacognitive awareness in the well-developed category. Based on declarative, procedural and conditional aspects of knowledge; monitoring and evaluating are in the well developed category, while for the planning aspect the category is starting to develop. Based on these findings, it is necessary to train students to. Write a journal regularly so that metacognitive awareness can be further improved until the category develops very well
THE EFFECT OF PROJECT BASED LEARNING MODEL WITH STEM APPROACH TO STUDENTS’ CRITICAL THINGKING SKILL ON HUMAN EXCRETION SYSTEM
Authors: Simatupang Halim , Fauzi Kms. Muhammad Amin , Dewi Izwita
Published: March 2024

This study was aimed to determine the effect of Project Based Learning Model with STEM approach to students' critical thinking skills on Human Excretion System material in class 8th grade at SMP Negeri 37 Medan. This research used quantitative methods with the type of research quasi experiment with pretest-posttest control group design. The sample of this study consisted of two classes randomly selected by simple random sampling technique, namely in class VIII-D and VIII-F. The first sample is an experimental class that was taught using the PjBL-STEM learning model, and the second sample is a control class that was taught using conventional learning methods. The research instrument that was used included critical thinking skills test instrument using essay questions totaling 5 questions. Analysis of research data used the Independent Sample T-Test test using SPSS version 26.0. The pretest data results of students' critical thinking skills in class VIII-D and class VIII-F are 33.71 and 29.35. After obtained the results of the initial ability of students by looking at the pretest results in both classes, class VIII-D was selected as the experimental class and class VII-F as the control class. The posttest data in the experimental class and control class are 80.00 and 52.58. Based on the hypothesis test, the calculated t value is 12.761 > t table 1.671, and the significance value is 0.000 < 𝛼, with 𝛼 = 0.05, so H0 is rejected and Ha was accepted, which meant that there was an effect of the PJBL-STEM model on the critical thinking skills of students on the material of the excretory system. The influence of the PJBL-STEM model on students' critical thinking skills was categorized as strong with a cohen's d value of 3.242. It can be concluded that the PJBL-STEM model have an effect on students' critical thinking skills with a strong effect category.
Factors Related to Type of Endometrial Cancer in RSUP Dr. M. Djamil Padang
Authors: Helmanda Shylvia , Yusrawati Yusrawati
Published: March 2024

Objective: This study aims to determine the relationship of risk factors with type of endometrial cancer.Method: This study used a cross sectional design in patients with endometrial cancer. Sampling uses total sampling technique, with a total sample of fifty six people. Data were obtained from the anatomical pathology section and medical records of Dr. RSUP M. Djamil Padang from 2016 until 2018. Analysis of data using Chi-Square test and logistic regressionResult: In this study, type I endometrial cancer is 75% cases while type II is 25% cases. Age, parity, diabetes mellitus, hypertension, genetics history and exclusive breastfeeding have no association with the type of endometrial cancer. The age of menarche and BMI have a relationship with the type of endometrial cancer. The dominant factor associated with the type of endometrial cancer is BMI (p = 0.042; OR = 6.547; 95% CI = 1.067-40.169), age (p = 0.037; OR = 4.854; 95% CI = 1.096-21.493), and age of menarche (p = 0.054; OR = 4.590; 95% CI = 0.974-21.635).Conclusion: On this research, BMI, age and age of menarche are the most dominant factor associated with the type of endometrial cancer.    Faktor yang Berhubungan dengan Tipe Kanker Endometrium di RSUP Dr. M. Djamil PadangAbstrakTujuan: Penelitian ini bertujuan untuk mengetahui hubungan faktor risiko dengan tipe kanker endometrium.Metode: Penelitian ini menggunakan desain cross sectional pada penderita kanker endometrium. Pengambilan sampel menggunakan teknik total sampling, dengan jumlah sampel sebanyak 56 orang. Data diperoleh dari bagian patologi anatomi dan rekam medik RSUP Dr. M. Djamil Padang periode 2016 – 2018. Analisis data menggunakan uji Chi-Square dan regresi logistic.Hasil: Pada penelitian ini ditemukan 75% kasus merupakan kanker endometrium tipe 1 dan 25% kanker endometrium tipe II. Usia, paritas, diabetes mellitus, hipertensi, riwayat genetik dan pemberian asi eksklusif tidak memiliki hubungan dengan tipe kanker endometrium. Usia menarche dan IMT memiliki hubungan dengan tipe kanker endometrium. Faktor yang dominan berhubungan dengan tipe kanker endometrium adalah IMT (p = 0,042; OR = 6,547; 95% CI = 1,067-40,169), usia (p = 0,037; OR = 4,854; 95% CI = 1,096-21,493), dan usia menarche (p = 0,054; OR = 4,590; 95% CI = 0,974-21,635).Kesimpulan: Pada penelitian ini, IMT, usia dan usia menarche merupakan faktor yang paling dominan mempengaruhi tipe kanker endometriumKata kunci: Kanker Endometrium, Faktor Risiko.
Recurrent multi-drug-resistant tuberculosis with unilateral destroyed lung in pregnancy: a case report
Authors: Febriana Irene Sinta , Atikah Sayugo , Pudyastuti Sri
Published: March 2024

Background: Multi-drug-resistant Tuberculosis (MDR-TB) remains a public health problem in developing countries such as Indonesia. The extensive parenchymal damage due to MDR-TB could manifest as an irreversible destroyed lung, leading to respiratory and  also cardiovascular complication. Its occurrence in pregnancy is uncommon but is highly associated with higher mortality and morbidity for both maternal and fetal.Case Report: We report a case of 24 year old primigravida in National Respiratory Center Hospital, diagnosed with  an unilateral destroyed lung due to MDR-TB in pregnancy at 32 weeks of gestational age. On initial presentation, she reported fatigue, nausea, night sweats, chronic dyspnoe and was found to have complete left destroyed lung. Her disease was managed during pregnancy using long-term oxygen therapy despite persistent desaturation.Conlusion: Aside from frequent monitoring, prolonged oxygen therapy might benefit the chronic hypoxia condition in gestational destroyed lung due to previous MDR-TB infection, for preventing maternal-fetal mortality and morbidities, such as respiratory failure and IUGR.AbstrakLatar Belakang: Tuberkulosis Multi-drug-resistant (TB-MDR) tetap menjadi masalah kesehatan pada negara berkembang, seperti Indonesia. Kerusakan parenkin luas yang diakibatkan oleh infeksi TB-MDR dapat bermanifestasi sebagai kerusakan paru ireversibel, dengan komplikasi respiratorik dan kardiovaskular. Kejadian kerusakan paru akibat TB-MDR dalam kehamilan jarang terjadi, namun berdampak pada peningkatan mortalitas dan morbiditas pada janin dan ibu. Laporan Kasus: Studi ini melaporkan kasus perempuan primigravida 24 tahun didiagnosa dengan kerusakan paru unilateral akibat infeksi TB-MDR pada kehamilan 32 minggu di RS Pusat Paru Nasional. Pada pemeriksaan awal, didapatkan pasien mengeluhkan kelelahan kronik, nausea, keringat malam, sesak kronik dan didapatkan memiliki kerusakan paru kiri komplit. Keadaan pasien dalam kehamilan ditatalaksana dengan terapi oksigen jangka panjang untuk mengatasi desaturasi persisten Kesimpulan: Di samping pengawasan ketat, terapi oksigen jangka panjang dapat menjadi tatalaksana utama untuk kondisi hipoksia kronik pada kerusakan paru dalam kehamilan akibat infeksi lama TB-MDR untuk mencegah morbiditas dan mortalitas ibu dan janin, seperti gagal napas dan pertumbuhan janin terhambat  (PJT).
Antiviral Treatment On Pregnancy With COVID-19 Infection : A Systematic Review
Authors: Simanjuntak Tigor Peniel , Kakerissa Angela Putri , Kurniawan Grady Ivan
Published: March 2024

Objective to evaluate antiviral treatment, duration, and side effects on pregnant women based on gestational age and severity of COVID-19 infection. Method: a systematic review of antiviral treatment, duration, and side effects on pregnant women based on gestational age and severity of COVID-19 infection. Systematic review was conducted following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Statement.  Result 948 papers accessed through Pubmed, Scopus, Science Direct, Cohcrane, and other with keywords “Antiviral”, “Pregnancy” “Pregnant” “Coronavirus” “COVID-19” “SARS-CoV-2”. Duplicate papers were excluded (n=302),  topics and abstracts that do not meet the criteria (n=612), and 25 papers that did not meet the inclusion criteria. 9 papers that meet the inclusion criteria (case reports and cohort retrospective case study) discussed 20 pregnant women with COVID-19 infection (16 moderate and severe cases received Remdesivir, 3 moderate and mild cases received Lopinavir-ritonavir combination, and 1 moderate case received Arbidol). Conclusion, remdesivir is an antiviral frequently used in pregnancy on trimester II and III with severe COVID-19 infection with a duration of treatment of 5-10 days. Remdesivir should be monitored because some show side effects of increasing liver function.Pengobatan Ibu Hamil yang Terinfeksi  COVID−19 dengan AntivirusAbstrakTujuan untuk mengevaluasi penggunaan obat antivirus, lama pengobatan, dan efek samping pada wanita hamil dengan infeksi COVID-19 berdasarkan usia kehamilan dan derajat keparahan. Metode tinjauan literatur sistematis tentang penggunaan obat antivirus, lama pengobatan, dan efek samping pada wanita hamil dengan infeksi COVID-19 berdasarkan usia kehamilan dan tingkat keparahan. Tinjauan sistematis mengikuti pedoman dari Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Hasil terdapat 948 jurnal yang diakses melalui Pubmed, Scopus, Science Direct, Cohcrane dan lainya dengan kata kunci : Antiviral, Pregnancy, Pregnant, Coronavirus, COVID-19, SARS-CoV-2. Terdapat jurnal yang terduplikasi (n=302), topik dan abstrak yang tidak sesuai kriteria (n=612), dan 25 jurnal yang tidak sesuai kriteria inklusi. Terdapat 9 jurnal yang memenuhi kriteria inklusi (laporan kasus dan studi retrosepktif kohort) yang membahas 20 wanita hamil dengan infeksi COVID-19 (16 kasus dengan derajat sedang dan berat menerima Remdesivir, 3 kasus derajat sedang dan ringan menerima kombinasi Lopinavir-ritonavir, dan 1 kasus derajat sedang menerima Arbidol). Kesimpulan, remdesivir adalah antivirus yang sering digunakan pada wanita hamil trisemester II dan III dengan infeksi COVID-19 derajat berat, lama pengobatan 5-10 hari. Remdesivir harus diwaspadai karena dapat menimbulkan efek samping seperti peningkatan fungsi hati. Kata kunci: Antivirus, Hamil, COVID-19
Pola Kuman dan Kepekaan Antibiotik pada Kasus Infeksi Luka Operasi Obstetri
Authors: Irawan Iwan , Sukarsa M. Rizkar Arev , Aziz M. Alamsyah
Published: March 2024

Tujuan: Mengetahui karakteristik pasien infeksi luka operasi (ILO) bidang Obstetri dan mendeskripsikan gambaran pola kuman serta kepekaan antibiotiknya di Rumah Sakit Umum Pusat (RSUP) Dr. Hasan Sadikin BandungMetode: Penelitian ini merupakan penelitian deskriptif observasional dengan pendekatan cross sectional yang bersifat retrospektif dari rekam medis pasien obstetri yang terdiagnosis infeksi luka operasi di RSUP Dr. Hasan Sadikin Bandung selama periode Juli 2020 - Juni 2021. Karakteristik subjek meliputi usia, berat badan, tinggi badan, body mass index (BMI),  dan paritas. Dalam penelitian ini digunakan tingkat ketelitian (α) 5%, tingkat kepercayaan 95% sehingga diperoleh nilai Z = 1,96. Deskripsi karakteristik dan status pasien ditampilkan dalam bentuk tabel. Data kategorik dideskripsikan dengan jumlah (n) dan persentase (%).Hasil: Hasil penelusuran rekam medis didapatkan sebanyak 20 pasien yang didiagnosis dengan ILO. Seluruh pasien yang mengalami ILO merupakan pasien pasca  seksio sesarea. Tidak didapatkan perbedaan yang bermakna pada rerata umur, berat badan, tinggi badan, BMI, dan sebaran paritas. Kesimpulan: ILO pada bidang obstetri seluruhnya terjadi pasca seksio sesarea. Tidak didapatkan perbedaan bermakna pada karakteristik pasien yang mengalami ILO. Pola kuman yang paling sering dijumpai adalah Escherichia coli dan Acinetobacter baumannii. Antibiotik yang sensitif terhadap mayoritas sampel adalah tigecycline dan meropenem.Antibiotic Susceptibility and Microbial Pattern in Obstetric Surgrical Wound InfectionAbstractObjective: To know the characteristics of surgical site infection (SSI) patients  in obstetrics field and describing the microbial pattern and their antibiotic sensitivity at the Hasan Sadikin General HospitalMethod: This study was a descriptive observational study with a retrospective cross sectional approach from the medical records of obstetric patients diagnosed with surgical wound infections at Dr. Hasan Sadikin Bandung during the period July 2020 - June 2021. Subject characteristics include age, weight, height, body mass index (BMI), and parity. In this study, the level of accuracy (α) 5%, 95% confidence level, so that the value of Z = 1.96 is obtained. Results: The results gained from tracing medical records and obtained as many as 20 patients diagnosed with SSI. All patients who experienced SSI were post-cesarean section patients. There were no significant differences in the mean age, weight, height, BMI, and parity distribution. Conclusion: There was a high prevalence of female sexual dysfunction among health practitioners at Hasan Sadikin General Hospital, accounting to 41.8%. There was no statistically significant difference between various demographic aspects and female sexual dysfunction. Key words: Microbial pattern, antibiotic, sensitivity, surgical site infection
Hubungan Luaran Maternal dan Perinatal Terhadap Tingkat Keparahan Infeksi COVID-19
Authors: Fitraendi FM. Dicky , Hidayat Dini , Pramatirta Akhmad Yogi
Published: March 2024

Tujuan: Penelitian ini dilakukan untuk mengetahui hubungan luaran maternal dan perinatal terhadap tingkat keparahan infeksi COVID-19 pada ibu bersalin di RSUP Dr. Hasan Sadikin Bandung.Metode: Penelitian ini menggunakan studi analitik observasional retrospektif dengan rancangan potong lintang menggunakan data rekam medik selama periode Maret 2020 hingga Juni 2021. Karakteristik subjek meliputi usia ibu, jumlah paritas, tingkat pendidikan, dan usia kehamilan. Luaran maternal meliputi hipertensi pada kehamilan, ketuban pecah dini, dan kejadian persalinan prematur. Hasil: Tidak ditemukan hubungan yang signifikan pada angka kejadian ketuban pecah dini (p-value 0,128) dan persalinan prematur (p-value 0,324) terhadap tingkat keparahan infeksi COVID-19.  Pada ibu dengan infeksi COVID-19 derajat ringan memiliki luaran perinatal asfiksia ringan sebanyak 132 bayi (89,3%), asfiksia sedang 43 bayi (32,6%) dan asfiksia berat 5 bayi (3,8%). Terdapat hubungan bermakna antara derajat asfiksia pada janin dengan tingkat keparahan infeksi COVID-19 (p-value 0,013).Kesimpulan: Terdapat hubungan bermakna antara kejadian hipertensi dalam kehamilan dan tingkat mortalitas ibu terhadap tingkat keparahan infeksi COVID-19. Derajat asfiksia pada bayi baru lahir memiliki hubungan yang signifikan dengan tingkat keparahan infeksi COVID-19. Correlation Of Maternal And Perinatal Outcomes with the Severity Of Covid-19 InfectionAbstractObjective: This study was conducted to evaluate the relationship between maternal and perinatal outcomes with the severity of COVID-19 infection in women giving birth at Dr. Hasan Sadikin BandungMethods: This study was a retrospective observational analytical study with a cross-sectional design that used medical record data between March 2020 to June 2021. Subject characteristics include maternal age, parity, education level, and gestational age. Maternal outcomes consist of hypertension in pregnancy, premature rupture of membranes, and the incidence of preterm labor. Results: There was no significant relationship between the incidence of premature rupture of membranes (p-value 0.128) and preterm delivery (p-value 0.324) on the severity of COVID-19 infection. Mothers with mild COVID-19 infection had mild asphyxia perinatal outcomes as many as 132 infants (89.3%), moderate asphyxia in 43 infants (32.6%), and severe asphyxia in 5 infants (3.8%). There is a significant relationship between the degree of asphyxia in the fetus and the severity of COVID-19 infection (p-value 0.013).Conclusion: There is a significant relationship between the incidence of hypertension in pregnancy and maternal mortality with the severity of COVID-19 infection. The degree of asphyxia in newborns has a significant relationship with the severity of COVID-19 infection.Key words: Maternal outcome, perinatal, severity, COVID-19 infection
The Comparison of Peripheral Blood Morphology and Ferritin Level in Pregnancy Woman with Anemia Living in Lowland and Highland Areas
Authors: Amita Yulfa Rizki , Hartono Eddy , Syahrir Syahruni , Hamid Firdaus , Rambulangi Samrichard , Jusuf Elizabet Catherine
Published: March 2024

Objective: Differences in the morphology features of red blood cells in population groups who live in the lowlands areas and the highlands areas will affect the diagnosis and appropriate therapies. Methods: The method used is a cross-sectional study of 75 pregnant women (6-38 weeks gestational age) with anemia living in highland and lowland areas found at Massenrempulu Hospital and Sitti Khadijah I Hospital. Anemia in pregnant women is diagnosed as a hemoglobin level less than 11gr/dl in the 1st and 3rd trimesters or less than 10.5 gr/dl in the 2nd trimester. The patient's blood sample was taken intravenously and performed serological and peripheral blood examination. Data were processed using the SPSS program, analyzed using univariate and multivariate tests.Results: In both results of the parametric and nonparametric test, ferritin levels showed a significant difference (p = 0.001), higher in the lowland areas group subjects (15.44 ± 36.92) compared to the highland areas group subjects (9.55 ± 30.16). There were no significant differences in morphology features (p> 0.05) between both groups.Conclusion: This study showed no significant differences in morphology features between the two groups. The lowland areas group subjects had a significantly higher ferritin level than that of the highland areas group subjects.Perbandingan Gambaran Morfologi Darah Tepi Pasien Gravid dengan Anemia Yang Tinggal di Pesisir Pantai dan Daerah PegununganAbstrakTujuan: Perbedaan ciri morfologi sel darah merah pada kelompok populasi yang tinggal di dataran rendah dan dataran tinggi akan mempengaruhi diagnosis dan terapi yang tepat.Metode: Metode yang digunakan adalah studi potong lintang pada 75 ibu hamil (usia kehamilan 6-38 minggu) dengan anemia yang tinggal di dataran tinggi dan dataran rendah yang ditemukan di RS Massenrempulu dan RS Sitti Khadijah I. Anemia pada ibu hamil didiagnosis berdasarkan kadar hemoglobin kurang dari 11gr/dl pada trimester I dan III atau kurang dari 10,5 gr/dl pada trimester II. Sampel darah pasien diambil secara intravena dan dilakukan pemeriksaan serologis dan darah tepi. Data diolah menggunakan program SPSS, dianalisis menggunakan uji univariat dan multivariat.Hasil: Pada hasil uji parametrik dan nonparametrik, kadar feritin menunjukkan perbedaan yang secara signifikan (p = 0,001), lebih tinggi pada subjek kelompok dataran rendah (15,44 ± 36,92) dibandingkan dengan subjek kelompok dataran tinggi (9,55 ± 30,16). Tidak ada perbedaan yang signifikan dalam morfologi darah tepi  (p> 0,05) antara kedua kelompok.Kesimpulan: Penelitian ini tidak menunjukkan perbedaan morfologi yang signifikan antara kedua kelompok. Subyek kelompok dataran rendah memiliki kadar feritin yang jauh lebih tinggi dibandingkan dengan subjek kelompok dataran tinggi.Kata kunci: Morfologi darah tepi, kehamilan, anemia, dataran rendah, dataran tinggi
Tiga Kasus Holoprosensefal Alobar dengan Variasi Gambaran Klinis:Diagnosis Ultrasonografi
Authors: Riu Deviana Soraya , Lukas Efendi
Published: March 2024

Holoprosensefal (HPE) adalah spektrum malformasi dengan berbagai hasil luaran. Laporan ini menjelaskan 3 kasus holoprosensefal alobar yang dikonfirmasi saat antenatal dengan pemeriksaan ultrasonografi (USG). Selain gambaran holoprosensefal alobar yang serupa pada ketiga kasus, ditemukan gambaran lain yaitu probosis, siklops, kelainan jantung, dan arteri umbilikalis tunggal. Gambaran klinis yang berbeda adalah preeklamsia, polidaktili, dan mikropenis pada kasus pertama, pada kasus kedua adalah mielomeningokel; dan hidransefal untuk kasus ketiga. Analisis kromosom dilakukan hanya pada kasus kedua dengan hasil berupa translokasi kromosom 3 ke 9 (46 XX, der (9) t(3:9)(p21:q33). Pencitraan menggunakan USG adalah modalitas yang bermanfaat untuk mendeteksi holoprosensefal alobar. Bila skrining dilakukan pada masa usia kehamilan yang tepat maka dapat ditemukan kelainan kongenital mayor letal secara dini, sehingga terminasi kehamilan lebih mudah dengan komplikasi yang lebih minimal.Three Cases Of Holoprosencephalic Alobar With A Variety Of Clinical Features: Ultrasound DiagnosticAbstractHoloprosencephaly (HPE) is a spectrum of malformations with various outcomes and the most common congenital brain disorder. This report describes 3 cases of alobar holoprosencephaly that were confirmed antenatally by ultrasound examination. Apart from the similar appearance of alobar holoprosencephaly in all three cases, other similar characteristics were proboscis, cyclopia, heart defects, and a single umbilical artery. The different clinical features were maternal preeclampsia, polydactyly, and micropenis in the first case. The different clinical feature in the second case was myelomeningocele; and hydranencephaly for the third case. Chromosome analysis was performed only in the second case with results in the form of translocation of chromosomes 3 to 9 (46 XX, der (9) t(3: 9)(p21: q33).If the chromosome analysis is limited, ultrasound imaging is beneficial for detecting alobar holoprosencephaly.Key words: alobar holoprosencephaly, myelomeningocele, hydranencephaly, preeclampsia
ACE2 Receptors Finding in Placenta with Intrauterine Fetal COVID-19 Infection: A Meta-Analysis
Authors: Simanjuntak Tigor Peniel , Wiranegara Hanny Hadinata , Wiranegara Temmy Hadinata
Published: March 2024

Objective: Association between ACE2 receptors in the placenta and the incidence of intrauterine COVID-19 infection in pregnant women infected with COVID-19 Methods: Systematic review and meta-analysis of placenta in pregnant women with COVID-19 infection, ACE2 receptor in placenta, and RT-PCR of neonates from COVID-19 pregnant women. This study followed the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) protocol. Results: 6 journals meet the inclusion criteria. ACE2 receptors were found in syncytiotrophoblasts 72/72 (100%), cytotrophoblasts 41/72 (56.9%), extravillous trophoblasts 24/72 (33.3%), decidual cells 2/72 (2.7%), villous stromal cells 1/72 (1.3%), and 1/72 stromal cells (1.3%) with the incidence of neonates infected with SARS-CoV-2 from pregnant women with COVID-19 10.5%, odds ratio (OR) between ACE2 receptors and neonates infected with COVID-19 is 1.97 (95%CI 0.05–81.09), the pooled proportion of ACE2 receptor findings in 72 placentas in pregnant women with COVID-19 infection, syncytiotrophoblast 98.3 (95% CI 94.3–99.9), cytotrophoblast 40.3 (95% CI 2.3–88.9), and extravillous trophoblast 35.2 (95% CI 0.2–88.5). Conclusion: Expression of ACE2 receptors is always present in the placenta of pregnant women, and there is an association but non-significant between ACE2 receptors in the placenta and the incidence of COVID-19 intrauterine infection with an odds ratio of 1.97 (95%CI 0.05-81.09).Reseptor ACE2 Pada Plasenta dengan Kejadian Infeksi COVID-19 Intrauterine Pada Fetus: A Meta-AnalysisAbstrakTujuan: Hubungan antara reseptor ACE2 di plasenta dengan angka kejadian infeksi COVID-19 intrauterine pada ibu hamil yang terinfeksi COVID-19. Metode: Tinjauan sistematis dan meta-analisis plasenta pada ibu hamil COVID-19, reseptor ACE2 pada plasenta, dan hasil uji RT-PCR neonatus dari ibu hamil COVID-19. Penelitian ini mengikuti protokol Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA). Hasil: 6 jurnal memenuhi kriteria. Reseptor ACE2 ditemukan di sinsitiotrofoblas 72/72 (100%), 41/72 sitotrofoblas (56.9%), trofoblas ekstravili 24/72 (33.3%), sel desidua 2/72 (2.7%), sel stroma vili 1/72 (1.3%), dan sel stroma 1/72 (1.3%) dengan insidensi neonatus yang terinfeksi SARS-CoV-2 dari ibu hamil dengan COVID-19 sebanyak 10.5%, odds ratio (OR) antara reseptor ACE2 dan neonatus terinfeksi COVID-19 adalah 1.97 (95%CI 0.05–81.09), proporsi gabungan penemuan reseptor ACE2 pada 72 plasenta ibu hamil COVID-19, sintiotrofoblas 98.3 (95%CI 94.3 – 99.9), sitotrofoblas 40.3 (95%CI 2.3 – 88.9), dan trofoblas ekstravili 35.2 (95%CI 0.2 – 88.5). Kesimpulan: Ekspresi reseptor ACE2 selalu ditemukan di plasenta ibu hamil, dan terdapat hubungan yang tidak bermakna antara reseptor ACE2 di plasenta dengan kejadian infeksi intrauterine COVID-19 yaitu odds ratio 1.97 (95%CI 0.05-81.09).Kata kunci : Infeksi COVID-19, Intrauterine, reseptor ACE2 plasenta.
Effect Of Corona Virus Disease 2019 (Covid-19) on the Incidence of Preterm Birth And Asphyxia at Banjar Regional General Hospital
Authors: Sholehah Kulfa , Pramatirta Akhmad Yogi , Wirakusumah Firman F.
Published: March 2024

Objective: This study aims to determine and analyze the effect of Corona Virus Disease (Covid-19) on the incidence of preterm birth and asphyxia at Banjar Regional General Hospital. Method: This was an analytical observational study with a retrospective cohort approach. The type of data involved in this study was secondary data derived from medical record with a total sample of 59 women in labor diagnosed with Covid-19 and 513 women in labor who were not diagnosed with Covid-19.Results : The result of the study showed that there was a significant difference in the incidence of preterm birth between women in labor diagnosed with Covid-19 and those who were not diagnosed with Covid-19 (ρ value=0.000 or ρ<0.05). Regarding the incidence of asphyxia, the result showed that there was no difference in the incidence of asphyxia between infants born to women diagnosed with Covid-19 and those born to women who were not diagnosed with Covid-19, with a ρ value of 0.523 or ρ>0.05. Women diagnosed with Covid-19 were at risk of giving birth to premature infants 5.308 times compared to women not diagnosed with Covid-19. The OR of the incidence of preterm birth was 5.308 with a 95% CI of 3.035-9.281. Furthermore, based on the statistical test result, it was revealed that Covid-19 had a low effect on the incidence of asphyxia with the OR value of 0.839 and a 95% CI of 0.489-1.439.Conclusion: Based on the results of the study, it can be concluded that there was an effect of Covid-19 just on the incidence of preterm birth.Pengaruh Corona Virus Disease 2019 (Covid-19) terhadap Kejadian Prematur dan Asfiksia di RSUD Kota BanjarAbstrak Tujuan: Penelitian ini mengukur dan menganalisis pengaruh Corona Virus Disease (Covid-19) terhadap kejadian prematur dan asfiksia di RSUD Kota Banjar. Metode: Penelitian berupa analitik observasi dengan pendekatan kohor retrospektif. Jenis data dalam penelitian ini adalah data sekunder dari rekam medis dengan jumlah sampel menggunakan total sampel yaitu 59 ibu bersalin dengan Covid-19 dan 513 ibu bersalin tidak dengan Covid-19.Hasil: Hasil penelitian menunjukkan terdapat perbedaan yang bermakna kejadian prematur pada Ibu Covid-19 dengan ibu yang tidak terdiagnosis Covid-19 (nilai ρ0.000) yang artinya p0.05. Ibu dengan Covid-19 berisiko melahirkan bayi prematur 5.308 kali dibandingkan pada ibu yang tidak terdiagnosis Covid-19, nilai OR kejadian prematur 5.308 dengan IK 95% 3.035-9.281. Dan dari hasil uji statistik diperoleh hasil yaitu Covid-19 berpengaruh rendah terhadap kejadian asfiksia dengan hasil uji statistik nilai OR 0.839 dengan IK 95% 0.489-1.439. Kesimpulan: Dari hasil penelitian dapat disimpulkan bahwa terdapat pengaruh Covid-19 terhadap kejadian prematur.Kata kunci: Asfiksia, Covid-19, Prematur