bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of the Application of Ochrobactrum sp.-Immobilised Biochar on the Remediation of Diesel-Contaminated Soil
Authors: Dike Charles Chinyere , Rani Batra Alka , Khudur Leadin S. , Nahar Kamrun , Ball Andrew S.
Published: March 2024

The immobilisation of bacteria on biochar has shown potential for enhanced remediation of petroleum hydrocarbon-contaminated soil. However, there is a lack of knowledge regarding the effect of bacterial immobilisation on biosolids-derived biochar for the remediation of diesel-contaminated soil. This current study aimed to assess the impact of the immobilisation of an autochthonous hydrocarbonoclastic bacteria, Ochrobacterium sp. (BIB) on biosolids-derived biochar for the remediation of diesel-contaminated soil. Additionally, the effect of fertiliser application on the efficacy of the BIB treatment was investigated. Biochar (BC) application alone led to significantly higher hydrocarbon removal than the control treatment at all sampling times (4887–11,589 mg/kg higher). When Ochrobacterium sp. was immobilised on biochar (BIB), the hydrocarbon removal was greater than BC by 5533 mg/kg and 1607 mg/kg at weeks 10 and 22, respectively. However, when BIB was co-applied with fertiliser (BIBF), hydrocarbon removal was lower than BIB alone by 6987–11,767 mg/kg. Quantitative PCR (q-PCR) analysis revealed that the gene related to Ochrobacterium sp. was higher in BIB than in the BC treatment, which likely contributed to higher hydrocarbon removal in the BIB treatment. The results of the q-PCR analysis for the presence of alkB genes and FTIR analysis suggest that the degradation of alkane contributed to hydrocarbon removal. The findings of this study demonstrate that bacterial immobilisation on biosolids-derived biochar is a promising technique for the remediation of diesel-contaminated soil. Future studies should focus on optimising the immobilisation process for enhanced hydrocarbon removal.
Involvement of ERK and Oxidative Stress in Airway Exposure to Cadmium Chloride Aggravates Airway Inflammation in Ovalbumin-Induced Asthmatic Mice
Authors: Wu Chendong , Hu Xinyue , Jiang Yuanyuan , Tang Jiale , Ge Huan , Deng Shuanglinzi , Li Xiaozhao , Feng Juntao
Published: March 2024

Inhalation represents a significant route of cadmium (Cd) exposure, which is associated with an elevated risk of lung diseases. This research study aims to evaluate the impact of repeated low-dose cadmium inhalation on exacerbating airway inflammation induced by ovalbumin (OVA) in asthma-afflicted mice. Mice were grouped into four categories: control (Ctrl), OVA, cadmium chloride (CdCl2), and OVA + cadmium chloride (OVA + CdCl2). Mice in the OVA group displayed increased airway mucus secretion and peribronchial and airway inflammation characterized by eosinophil cell infiltration, along with elevated levels of Th2 cytokines (IL-4, IL-5, IL-13) in bronchoalveolar lavage fluids (BALFs). These parameters were further exacerbated in the OVA + CdCl2 group. Additionally, the OVA + CdCl2 group exhibited higher levels of the oxidative stress marker malondialdehyde (MDA), greater activity of glutathione peroxidase (GSH-Px), and higher phosphorylation of extracellular regulated kinase (ERK) in lung tissue. Treatment with U0126 (an ERK inhibitor) and α-tocopherol (an antioxidant) in the OVA + CdCl2 group resulted in reduced peribronchial and airway inflammation as well as decreased airway mucus secretion. These findings indicate that CdCl2 exacerbates airway inflammation in OVA-induced allergic asthma mice following airway exposure. ERK and oxidative stress are integral to this process, and the inhibition of these pathways significantly alleviates the adverse effects of CdCl2 on asthma exacerbation.
Chlorogenic Acid Intravesical Therapy Changes Acute Voiding Behavior of Systemic Lipopolysaccharide Inflammation-Induced Cystitis Bladder in Mice
Authors: Yeh Chung-Hsin , Praveen Rajneesh Chellappan , Liao Chun-Hou , You Wen-Chen , Chen Kuo-Chiang , Wu Yi-No , Chiang Han-Sun
Published: March 2024

This study explores the potential efficacy of chlorogenic acid (CGA) in mitigating lipopolysaccharide (LPS)-induced cystitis in a mice model. C57BL/6J mice were divided into four groups: normal control (NC), LPS, LPS + low CGA, and LPS + high CGA. Evaluation methods included cystometrogram (CMG), histopathological, western blot, and immunohistological analysis. In the LPS group, CMG revealed abnormal voiding behavior with increased micturition pressure, voided volume (VV), and decreased voided frequency. Low CGA treatment in LPS mice demonstrated improved micturition pressure and inter-contraction intervals (ICI). However, high CGA treatment exhibited prolonged ICI and increased VV, suggesting potential adverse effects. Histological analysis of LPS-treated mice displayed bladder inflammation and interstitial edema. Low CGA treatment reduced interstitial edema and bladder inflammation, confirmed by Masson’s trichrome staining. Western blotting revealed increased cytokeratin 20 (K20) expression in the low CGA group, indicating structural abnormalities in the bladder umbrella layer after LPS administration. In conclusion, low CGA treatment positively impacted voiding behavior and decreased bladder edema and inflammation in the LPS-induced cystitis mice model, suggesting its potential as a supplement for inflammation cystitis prevention. However, high CGA treatment exhibited adverse effects, emphasizing the importance of dosage considerations in therapeutic applications.
Evaluation of a Proportional Response Addition Approach to Mixture Risk Assessment and Predictive Toxicology Using Data on Four Trihalomethanes from the U.S. EPA’s Multiple-Purpose Design Study
Authors: Teuschler Linda K. , Hertzberg Richard C. , McDonald Anthony , Sey Yusupha Mahtarr , Simmons Jane Ellen
Published: March 2024

In this study, proportional response addition (Prop-RA), a model for predicting response from chemical mixture exposure, is demonstrated and evaluated by statistically analyzing data on all possible binary combinations of the four regulated trihalomethanes (THMs). These THMs were the subject of a multipurpose toxicology study specifically designed to evaluate Prop-RA. The experimental design used a set of doses common to all components and mixtures, providing hepatotoxicity data on the four single THMs and the binary combinations. In Prop-RA, the contribution of each component to mixture toxicity is proportional to its fraction in the mixture based on its response at the total mixture dose. The primary analysis consisted of 160 evaluations. Statistically significant departures from the Prop-RA prediction were found for seven evaluations, with three predications that were greater than and four that were less than the predicted response; interaction magnitudes (n-fold difference in response vs. prediction) ranged from 1.3 to 1.4 for the former and 2.6 to 3.8 for the latter. These predictions support the idea that Prop-RA works best with chemicals where the effective dose ranges overlap. Prop-RA does not assume the similarity of toxic action or independence, but it can be applied to a mixture of components that affect the same organ/system, with perhaps unknown toxic modes of action.
Neglected Spleen Transcriptional Profile Reveals Inflammatory Disorder Conferred by Rabbit Hemorrhagic Disease Virus 2 Infection
Authors: Yu Jifeng , Li Yan , Xiao Lu , Xie Jing , Guo Zhiqiang , Ye Yonggang , Lin Yi , Cao Ye , Wu Xuejing , Mao Congjian , Li Xingyu , Pan Meng , Ye Jianqiang , Zhou Long , Huang Jian , Yang Junyan , Wei Yong , Zhang Xianhui , Zhang Bin , Kang Runmin
Published: March 2024

Rabbit hemorrhagic disease (RHD) is an acute fatal disease caused by the rabbit hemorrhagic disease virus (RHDV). Since the first outbreaks of type 2 RHDV (RHDV2) in April 2020 in China, the persistence of this virus in the rabbit population has caused substantial economic losses in rabbit husbandry. Previous failures in preventing RHDV2 prompted us to further investigate the immune mechanisms underlying the virus’s pathogenicity, particularly concerning the spleen, a vital component of the mononuclear phagocyte system (MPS). For this, a previous RHDV2 isolate, CHN/SC2020, was utilized to challenge naive adult rabbits. Then, the splenic transcriptome was determined by RNA-Seq. This study showed that the infected adult rabbits had 3148 differentially expressed genes (DEGs), which were associated with disease, signal transduction, cellular processes, and cytokine signaling categories. Of these, 100 upregulated DEGs were involved in inflammatory factors such as IL1α, IL-6, and IL-8. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that these DEGs were significantly enriched in the cytokine–cytokine receptor interaction signaling pathway, which may play a vital role in CHN/SC2020 infection. At the same time, proinflammatory cytokines and chemokines were significantly increased in the spleen at the late stages of infection. These findings suggested that RHDV2 (CHN/SC2020) might induce dysregulation of the cytokine network and compromise splenic immunity against viral infection, which expanded our understanding of RHDV2 pathogenicity.
Human Herpes Virus-6 (HHV-6) Reactivation after Hematopoietic Cell Transplant and Chimeric Antigen Receptor (CAR)- T Cell Therapy: A Shifting Landscape
Authors: Kampouri Eleftheria , Handley Guy , Hill Joshua A.
Published: March 2024

HHV-6B reactivation affects approximately half of all allogeneic hematopoietic cell transplant (HCT) recipients. HHV-6B is the most frequent infectious cause of encephalitis following HCT and is associated with pleiotropic manifestations in this setting, including graft-versus-host disease, myelosuppression, pneumonitis, and CMV reactivation, although the causal link is not always clear. When the virus inserts its genome in chromosomes of germ cells, the chromosomally integrated form (ciHHV6) is inherited by offspring. The condition of ciHHV6 is characterized by the persistent detection of HHV-6 DNA, often confounding diagnosis of reactivation and disease—this has also been associated with adverse outcomes. Recent changes in clinical practice in the field of cellular therapies, including a wider use of post-HCT cyclophosphamide, the advent of letermovir for CMV prophylaxis, and the rapid expansion of novel cellular therapies require contemporary epidemiological studies to determine the pathogenic role and spectrum of disease of HHV-6B in the current era. Research into the epidemiology and clinical significance of HHV-6B in chimeric antigen receptor T cell (CAR-T cell) therapy recipients is in its infancy. No controlled trials have determined the optimal treatment for HHV-6B. Treatment is reserved for end-organ disease, and the choice of antiviral agent is influenced by expected toxicities. Virus-specific T cells may provide a novel, less toxic therapeutic modality but is more logistically challenging. Preventive strategies are hindered by the high toxicity of current antivirals. Ongoing study is needed to keep up with the evolving epidemiology and impact of HHV-6 in diverse and expanding immunocompromised patient populations.
Global Disparities in Access to Vaccine Clinical Trials: A Review of the Literature
Authors: Mardini Ali , Shaykhon Norhan , Khan Asher , Mardini Ahmad , Saeed Hajirah N.
Published: March 2024

Vaccines are an effective tool to reduce the disease burden from infectious diseases on a population, infrastructural, and individual level. Before vaccines can be administered to populations at large, they must go through rigorous testing in the form of clinical trials. While vaccine trials can be used to assess the efficacy of interventions on a local populace as well as target local endemic diseases, most clinical trials are sponsored and conducted by companies in high-income countries (HICs). This can lead to vaccines that are not optimized for low- and middle-income countries (LMICs) and that often neglect to address diseases specific to the local population. This narrative review aims to explore the factors leading to discrepancies in the execution of and access to vaccine trials between HICs and LMICs, thus guiding future efforts in confronting them. This review was written using the literature sourced from the PubMed database and supplemented with articles from Google Scholar along with grey literature. Several themes are highlighted including poorly defined regulatory and ethical guidelines, staff shortages, lack of research infrastructure, and logistical barriers. We discuss how these challenges have affected vaccine development in various capacities through case examples of SARS-CoV-2, poliovirus, and malaria. Many challenges remain in equitable vaccine clinical trial development and implementation. Facilitating the implementation of locally sponsored vaccine clinical trials in LMICs may be one avenue to address these challenges. In doing so, LMICs can become active stakeholders in the health of their citizens by addressing endemic diseases, tailoring vaccine specifications based on local needs, and implementing wide-scale vaccine access and delivery.
Design and Evaluation of Chimeric Plasmodium falciparum Circumsporozoite Protein-Based Malaria Vaccines
Authors: Stump William H. , Klingenberg Hayley J. , Ott Amy C. , Gonzales Donna M. , Burns James M.
Published: March 2024

Efficacy data on two malaria vaccines, RTS,S and R21, targeting Plasmodium falciparum circumsporozoite protein (PfCSP), are encouraging. Efficacy may be improved by induction of additional antibodies to neutralizing epitopes outside of the central immunodominant repeat domain of PfCSP. We designed four rPfCSP-based vaccines in an effort to improve the diversity of the antibody response. We also evaluated P. falciparum merozoite surface protein 8 (PfMSP8) as a malaria-specific carrier protein as an alternative to hepatitis B surface antigen. We measured the magnitude, specificity, subclass, avidity, durability, and efficacy of vaccine-induced antibodies in outbred CD1 mice. In comparison to N-terminal- or C-terminal-focused constructs, immunization with near full-length vaccines, rPfCSP (#1) or the chimeric rPfCSP/8 (#2), markedly increased the breadth of B cell epitopes recognized covering the N-terminal domain, junctional region, and central repeat. Both rPfCSP (#1) and rPfCSP/8 (#2) also elicited a high proportion of antibodies to conformation-dependent epitopes in the C-terminus of PfCSP. Fusion of PfCSP to PfMSP8 shifted the specificity of the T cell response away from PfCSP toward PfMSP8 epitopes. Challenge studies with transgenic Plasmodium yoelii sporozoites expressing PfCSP demonstrated high and consistent sterile protection following rPfCSP/8 (#2) immunization. Of note, antibodies to conformational C-terminal epitopes were not required for protection. These results indicate that inclusion of the N-terminal domain of PfCSP can drive responses to protective, repeat, and non-repeat B cell epitopes and that PfMSP8 is an effective carrier for induction of high-titer, durable anti-PfCSP antibodies.
Historical Phosphorus Mass and Concentrations in Utah Lake: A Case Study with Implications for Nutrient Load Management in a Sorption-Dominated Shallow Lake
Authors: Taggart Jacob B. , Ryan Rebecca L. , Williams Gustavious P. , Miller A. Woodruff , Valek Rachel A. , Tanner Kaylee B. , Cardall Anna C.
Published: March 2024

Utah Lake is unusual due to its large surface area, shallow depth, phosphorus-rich sediments, and well-mixed, unstratified waters. This creates conditions where water column phosphorous concentrations tend toward equilibrium, with lake sediments containing high concentrations of geologic phosphorus. To help understand the potential impact of phosphorous load reductions, we computed a time history of phosphorus mass in the lake using state and federal records of lake volume, dissolved phosphorus concentrations, and outflow. We show that historically, Utah Lake phosphorus concentrations have remained stable over time, in the range of 0.02 to 0.04 mg/L, despite large changes in lake volume and internal phosphorus mass. We performed sorption calculations using data from the literature, demonstrating that it would take unrealistically large load changes to alter water column phosphorus concentrations under sorption processes. The sorption model produces results consistent with historical data that show relatively constant phosphorous concentrations despite large lake volume changes. We show, through several lines of evidence, that water column phosphorus concentrations are insensitive to external loads. Phosphorous load reduction is unlikely to have a significant effect on phosphorus concentrations in Utah Lake and, by extension, in other sorption-dominated shallow lakes with phosphorus-rich sediment.
Machine Learning Models for Water Quality Prediction: A Comprehensive Analysis and Uncertainty Assessment in Mirpurkhas, Sindh, Pakistan
Authors: Abbas Farkhanda , Cai Zhihua , Shoaib Muhammad , Iqbal Javed , Ismail Muhammad , Arifullah  , Alrefaei Abdulwahed Fahad , Albeshr Mohammed Fahad
Published: March 2024

Groundwater represents a pivotal asset in conserving natural water reservoirs for potable consumption, irrigation, and diverse industrial uses. Nevertheless, human activities intertwined with industry and agriculture contribute significantly to groundwater contamination, highlighting the critical necessity of appraising water quality for safe drinking and effective irrigation. This research primarily focused on employing the Water Quality Index (WQI) to gauge water’s appropriateness for these purposes. However, the generation of an accurate WQI can prove time-intensive owing to potential errors in sub-index calculations. In response to this challenge, an artificial intelligence (AI) forecasting model was devised, aiming to streamline the process while mitigating errors. The study collected 422 data samples from Mirpurkash, a city nestled in the province of Sindh, for a comprehensive exploration of the region’s WQI attributes. Furthermore, the study probed into unraveling the interdependencies amidst variables in the physiochemical analysis of water. Diverse machine learning classifiers were employed for WQI prediction, with findings revealing that Random Forest and Gradient Boosting lead with 95% and 96% accuracy, followed closely by SVM at 92%. KNN exhibits an accuracy rate of 84%, and Decision Trees achieve 77%. Traditional water quality assessment methods are time-consuming and error-prone; a transformative approach using artificial intelligence and machine learning addresses these limitations. In addition to WQI prediction, the study conducted an uncertainty analysis of the models using the R-factor, providing insights into the reliability and consistency of predictions. This dual approach, combining accurate WQI prediction with uncertainty assessment, contributes to a more comprehensive understanding of water quality in Mirpurkash and enhances the reliability of decision-making processes related to groundwater utilization.
Synthetic Time Series Data in Groundwater Analytics: Challenges, Insights, and Applications
Authors: Pulla Sarva T. , Yasarer Hakan , Yarbrough Lance D.
Published: March 2024

This study presents ‘Synthetic Wells’, a method for generating synthetic groundwater level time series data using machine learning (ML) aimed at improving groundwater management in contexts where real data are scarce. Utilizing data from the National Water Information System of the US Geological Survey, this research employs the Synthetic Data Vault (SDV) framework’s Probabilistic AutoRegressive (PAR) synthesizer model to simulate real-world groundwater fluctuations. The synthetic data generated for approximately 100 wells align closely with the real data, achieving a quality score of 70.94%, indicating a reasonable replication of groundwater dynamics. A Streamlit-based web application was also developed, enabling users to generate custom synthetic datasets. A case study in Mississippi, USA, demonstrated the utility of synthetic data in enhancing the accuracy of time series forecasting models. This unique approach represents an innovative first-of-its-kind tool in the realm of groundwater research, providing new avenues for data-driven decision-making and management in hydrological studies.
Coronary Heart Disease Prediction: A Novel Deep Learning-based Approach
Authors: Kutiame Solomon , Millham Richard , Adekoya Adebayor Felix , Weyori Benjamin Asubam , Tettey Mark M.
Published: March 2024

Coronary Heart Disease (CHD) is reported to be one of the world’s deadliest diseases. Early prediction or detection and diagnosis of the disease can help prevent, cure, and reduce the damage it could cause. Artificial intelligent techniques such as Machine Learning and Deep Learning have proven useful for the early detection and prediction of disease. However, issues of irrelevant and redundant features in open datasets have contributed to low classification accuracy rates and high misclassification rates. This leaves a gap for continuous approaches for smart feature selection and high-performing models in the field for better results. This study investigates the impacts of cardiologist-inspired datasets and PCA dimensionality reduction techniques on the performance of CHD prediction. The compared results show that while PCA improves the CHD prediction accuracy for datasets obtained from cardiologists, there exist no statistically significant differences in the efficacy of the PCA method for CHD classification when applied to open datasets, however, MLP and LSTM offer promising results. The results further indicated that the effectiveness of expert-based feature selection techniques on CHD classification is relatively stable when compared with open-source datasets.
Exploring the Potential in Combining the Two Molecular Approaches, COI Barcoding and PCR-RFLP (COIBar-RFLP) in Identification of Selected Species of the Family Carangidae
Authors:   Department of Zoology, Faculty of Science, University of Ruhuna, Matara, Sri Lanka, GAMAGE LAHIRU MADUSHAN PANDI , MUNASINGHE DONA HEMALI NANDANA , RUPASINGHE MARINGA APSARA MADUMANJAREE
Published: March 2024

The family Carangidae is considered a markedly diverse, widespread taxon. Due to the characteristic “cryptic diversity” and “hybrid speciation” within the family, there is an exigency for taxonomic approaches that go beyond traditional phenotypic modus in identifying species. Mitochondrial cytochrome c oxidase subunit - I (COI) barcoding gene region plays a significant role over phenotypic characters in identifying species. This study evaluates the combination of the two molecular approaches: the COI DNA barcoding and PCR-RFLP for judicious species discrimination. The partial mitochondrial COI gene region of the selected Carangid fish species was amplified, sequenced and confirmed sequences with a mean length of 655 bp were submitted to the main databases; NCBI and BOLD. Intraspecific and interspecific nucleotide divergences were computed by the Kimura-2-Parameter (K2P) and they ranged between (0.00–2.96 %) and (6.46–21.83 %), respectively. The possibility of acquiring the same RFLP profiles given by the restriction enzymes HaeIII and MbOII was observed by the theoretical cleavage of 250 reference sequences of the corresponding gene. Hence, major and minority composite haplotypes of each species were obtained based on the fragment types derived by both HaeIII and MbOII. The resulting divergence values were compatible with the previously reported values for marine fish species. All the species were clearly differentiated by both RFLP banding patterns and the highest probability assumption of getting the same RFLP profile was compatible with the most abundant composite haplotype of each species. This reveals the practicability of the combination of two consolidated molecular approaches, COI barcoding and PCR-RFLP (COIBar-RFLP).
Embedding Search for Quranic Texts based on Large Language Models
Authors: Alqarni Mohammed
Published: March 2024

Semantic search is the process of retrieving relevant information from a large corpus of texts based on the meaning and context of the query. This paper is introduced in order to explore the use of large language models for semantic search of Quranic texts. The Quran, which is the central religious text of Islam, contains rich and complex linguistic and semantic features that pose challenges for traditional keyword-based search methods. This study investigates a semantic search approach utilizing. Large Language Models (LLM) embedding and assess the performance of LLM embedding in comparison to a baseline embedding-based search method using a set of queries that represent different semantic search levels. In addition, this study will also discuss the limitations and implications of using large language models for semantic search of Quranic texts and suggest directions for future research. A significant finding in this study is the consistent effectiveness of the LLM embedding across varying semantic complexities. This suggests that embedding using LLMs can capture deep semantic connections effectively. On the other hand, as a second finding, the state-of-the-art transformer, AraT5, outperforms LLM embeddings in low-level semantic searches, indicating potential for further LLM fine-tuning on Arabic text corpora.
Archives historiques et sédimentaires des paysages lacustres du piedmont des Pyrénées (lacs de Barbazan et de Loures-Barousse, Haute Garonne, France)
Authors: Arricau Victor , Chapron Emmanuel
Published: March 2024

Centré sur les lacs de Barbazan et de Loures-Barousse en Haute-Garonne (nord des Pyrénées françaises), ce travail illustre

comment les archives sédimentaires (d’origine glaciaire, lacustre ou fluviatile) des lacs résiduels, des paléolacs et des «néolacs »

permettent de compléter des approches géohistoriques et paysagères basées sur des archives iconographiques pour reconstituer l’évolution des paysages lacustres. Le couplage de ces approches méthodologiques permet de préciser l’évolution des paléopaysages lacustres sur le temps long et de mieux comprendre l’exposition des territoires de piedmont aux risques de crue. Sur le plan méthodologique, cette étude démontre également la pertinence de la méthodologie limnogéologique (sondeur de sédiments et

carottage gravitaire) pour l’étude des «néo » lacs, comme le lac artificiel de Loures-Barousse.
Paysages et usages des lacs alpins
Authors: Gauchon Christophe
Published: March 2024

Les trois grands lacs périalpins, le Léman, le Bourget et le lac d’Annecy, sont aujourd’hui connus comme destinations touristiques, lieux de villégiature souvent prisés et décors paysagers à fort potentiel promotionnel. Et ces fonctions tendent à éclipser ce que fut la diversité des usages passés de ces lacs. Or ces usages ont contribué à façonner les paysages lacustres tels que nous les percevons aujourd’hui, y compris lorsque les fonctions se sont estompées ou ont disparu : navigation, pêche, premières formes de loisirs, puis de plus en plus aménités résidentielles.
Le tourisme lacustre comme stratégie de diversification d’une destination touristique estampillée « montagne » : entre discours et réalité
Authors: Duval-Massaloux Mélanie , Mathieu Julien , Nikolli Alice
Published: March 2024

L’article porte sur la communication des destinations touristiques et interroge les relations entre, d’une part, les stratégies promotionnelles impulsées par des acteurs départementaux du tourisme et, d’autre part, la manière dont les acteurs locaux s’approprient ce type de démarche et s’en font les relais. Pour ce faire, l’article met en perspective la stratégie «quatre lacs » développée par Savoie Mont Blanc Tourisme (SMBT) et la place actuellement occupée par les lacs périalpins dans les discours et les images produites et véhiculées par les offices de tourisme (OT) des départements de la Savoie et de la Haute-Savoie. À un instant t qui est celui de l’année 2019, l’article analyse dès lors dans quelle mesure les OT de ces deux départements, acteurs dans la construction de la destination touristique et prescripteurs d’activités touristiques, considèrent les lacs comme des ressources touristiques à mettre en avant auprès de leurs visiteurs. En travaillant à partir d’OT situés en différents endroits des deux départements (environnement urbain, environnement lacustre, zones rurales, hautes vallées alpines, stations de ski), plus ou moins proches sur le plan kilométrique d’un des quatre lacs du territoire «Savoie Mont Blanc » , il s’agit de questionner les échelles auxquelles les lacs sont identifiés comme faisant ressource et d’interroger dans quelle mesure les dynamiques engagées par SMBT en matière de création d’une «destination lacs » sont partagées et relayées par l’échelon local, ici envisagé par le prisme des OT. Après avoir exposé la stratégie «quatre lacs » développée par SMBT et précisé l’organisation des OT en Savoie et en Haute-Savoie,

l’article présente la méthodologie développée ainsi que les principaux résultats obtenus, mettant en avant des décalages entre la

stratégie portée par SMBT et la manière dont les lacs sont perçus par les OT comme faisant (ou non) ressource.
François-Thomas, dit Franck, de Noé, botaniste, membre fondateur de la SBF, quelque peu effacé des mémoires…
Authors: Decoursier-Sandoz Françoise , Charpin André
Published: March 2024

Eléments biographiques de François-Thomas, dit Franck, de Noé (1806-1887).
Kidney Stones Account for Increased Imaging Studies in Autosomal Dominant Polycystic Kidney Disease
Authors: Simmons Kathryn E. , Ullman Lawrence S. , Dahl Neera K.
Published: March 2024

Key Points

Kidney stones are common in patients with autosomal dominant polycystic kidney disease compared with matched controls with CKD.

The increase in imaging seen in patients with autosomal dominant polycystic kidney disease correlates with the kidney stone burden in these patients.

Background

Patients with autosomal dominant polycystic kidney disease (ADPKD) may have more imaging studies than patients with other forms of CKD. We characterized the imaging burden of patients with ADPKD relative to a CKD population to determine which factors lead to increased imaging in patients with ADPKD.

Methods

We retrospectively reviewed patients seen at Yale Nephrology between January 2012 and January 2021. We collected demographic, clinical, and imaging data through automated query and manual chart review. Eight hundred seven patients with ADPKD were matched to 4035 CKD controls on the basis of criteria of sex, race, ethnicity, CKD stage, hypertension, and diabetes, but not age. The number of abdominal imaging studies were compared between ADPKD and CKD groups, and the effect of kidney stone diagnosis was further evaluated. Chi-square and t tests were used to evaluate demographic variables, and Kruskal Wallis and negative binomial regression models were used to evaluate differences between abdominal imaging studies.

Results

Patients with ADPKD had a greater number of total abdominal imaging studies (P < 0.0001), ultrasounds (P < 0.0001), and magnetic resonance imagings (P = 0.02) compared with controls. In patients with preserved renal function (eGFR >60 ml/min per m2), these differences persisted. Kidney stones were significantly more common among patients with ADPKD (P < 0.0001). In multivariable assessment of imaging study counts using a negative binomial model controlling for kidney stones, ADPKD was no longer a significant predictor. In patients with ADPKD, pyelonephritis; cyst complications; lower eGFR; diabetes; coronary artery disease; kidney stones; lower body mass index; and being male, Black, and younger increased the likelihood of having more imaging studies.

Conclusions

The higher prevalence of abdominal imaging studies in patients with ADPKD correlated with the increased incidence of kidney stones observed in this population.
Gradnja nove zgrade zavoda sv. Jeronima Rimu i mozaici Joze Kljakovića
Authors: Dukić Josip
Published: March 2024

Za Papinski hrvatski zavod sv. Jeronima, koji se do 1971. nazivao “Ilirski zavod sv. Jeronima”, od 27. prosinca 1928., kada je Juraj Mađerec (1885. – 1957.) preuzeo službu rektora, započelo je nešto mirnije razdoblje, u kojem je, između ostalog, sagrađena i nova zavodska zgrada. Zgrada je otvorena 12. studenoga 1939. godine. Za umjetničko uređenje zgrade rektor J. Mađerec je na preporuku zagrebačkog svećenika Svetozara Rittiga odabrao poznate hrvatske umjetnike Ivana Meštrovića i Jozu Kljakovića. U središtu ovog rada su tri mozaika J. Kljakovića (Krist knez mira, Pokrštenje Hrvata, Krunjenje Zvonimira) i okolnosti njihova nastajanja. Mozaici su na sjeverno pročelje nove zavodske zgrade postavljeni u burnim ratnim i poratnim okolnostima. Prvi, središnji mozaik Krist knez mira otkriven je 30. listopada 1944. u vrijeme rektorâ J. Mađerca, a dva pokrajnja Pokrštenje Hrvata i Krunjenje Zvonimira u vrijeme njegova nasljednika Đure Kokše, čija je služba u Zavodu trajala od 1959. do 1979. godine. Rad na pokrajnjim mozaicima Kljaković je započeo 20. srpnja 1959. i dovršio po svemu sudeći krajem 1961. ili u proljeće 1962. godine. Ovaj rad je nastao na temelju objavljene i neobjavljene, pisane i fotografske građe, koja se čuva u arhivu Zavoda sv. Jeronima i predstavlja nadopunu prethodnih istraživanja.
Some strong dimers of TNAZ - DFT treatment
Authors: Türker Lemi
Published: March 2024

TNAZ is an explosive material. Presently, some strong dimers of TNAZ have been investigated within the constraints of density functional theory at the level of B3LYP/6-31G(d,p). Core structure of the dimers of consideration is theoretically derived from pseudocyclacene structure by means of certain centric perturbations, and then nitro groups are attached at the desired positions or from two TNAZ molecules via certain intermolecular perturbations. All the present dimers are electronically stable, thermodynamically exothermic and have favorable Gibbs’ free energy of formation values at the standard states. Various structural and quantum chemical properties, including UV-VIS spectra have been obtained and discussed.
KOMBINASI FERMENTASI TEPUNG PUTAK DAN TEPUNG DAUN LAMTORO DALAM PAKAN TERHADAP PERTUMBUHAN DAN KELANGSUNGAN HIDUP IKAN BANDENG (Chanos chanos)
Authors: TAEK ARNOLDIANUS , Tjendanawangi Agnette , Djonu Asriati
Published: March 2024

Penelitian bertujuan mengkaji pertumbuhan dan kelulushidupan ikan bandeng perlakukan kombinasi tepung putak hasil fermentasi dan tepung daun lamtoro hasil difermentasi. Penelitian ini dilakukan menggunakan metode eksperimen dan perancangannya menggunakan Rancangan Acak Lengkap (RAL) dengan lima perlakuan dan tiga ulangan. Perlakuan yang dicobakan adalah A: fermentasi Tepung putak 25 % dan fermentasi tepung daun lamtoro 75 %; Perlakuan B: fermentasi tepung putak 50 % dan fermentasi tepung daun lamtoro 50 %; Perlakuan C: fermentasi tepung putak 75 % dan fermentasi tepung daun lamtoro 25 %; Perlakuan D: fermentasi tepung putak 100 %; perlakuan E: fermentasi tepung daun lamtoro 100 %. Perlakuan terbaik adalah  perlakuan   penggunaan kombinasi  fermentasi tepung  putak 75% dan fermentasi tepung daun lamtoro 25% dalam pakan yang memberikan pertambahan bobot mutlak  terbesar yaitu  15,96 g, pertumbuhan spesifik harian 1,83 g%/hari dan kelangsungan hidup 100%.
Watching English Native Speakers’ Youtube Channel to Improve Students’ Pronunciation Ability
Authors: Hasanah Maufiratul , Wahono Suparwoto Sapto
Published: March 2024

Pronunciation is the way a letter, word, or language is spoken. It involves how a speaker produces sounds, stress, rhythm, and intonation in speech. Some English learners have difficulty with pronunciation since English is considered to be a foreign language in Indonesia. This research aims to show that watching English native speakers’ YouTube channel can improve students’ pronunciation ability. The researcher applied Classroom Action Research and it needed two cycles (four meetings). The criteria of success were that the students achieve the minimum standard or average score, which was equal to or greater than 70%. The students’ pretest score was 35% (very poor) and the result of the interview with the English teacher suggested that the students could not pronounce accurately since they rarely practice and never learn from native speakers. The first posttest score was 57,5% (very poor). The second posttest score was 87% (very good). It showed that the students’ score was increase and achieve the minimum standard. It could be concluded that watching English native speakers’ YouTube channel is an effective way to improve the students’ pronunciation ability.
Analyzing Undergraduate Students’ Errors in Writing Descriptive Text
Authors: Aisyah Noor , Yulianto Puguh Setiyawan
Published: March 2024

This study aimed to identify the students’ errors and find the most errors students made. This study used qualitative approach having descriptive approach the research method. The sample were 35 college students in the University at the first semester in English class which selected purposively. The data was collected through the writing test. It is used to identify the type of errors students’ made and the highest errors students’ made in writing descriptive text by using simple present tense. The writing test is conducted two times. After those, the data were analyzed and found the result. The result showed that there were 510 errors found in students’ works, consisting of omission of “be”, inappropriate use of “be”, superfluous of be, subject-verb agreement, wrong form of have/has, wrong form of negative sentence, inappropriate use of pronoun and wrong form of modal auxiliary. The highest number of errors was subject-verb agreement at the first rank with 138 errors or 27% and omission “be” after subject at the second rank with 125 errors or 22.5% and the lowest numbers of error were inappropriate use of pronoun and inappropriate form of negative sentence with 11 error or 2.2 %.  Based on the result, it can be found that students have difficulties in writing descriptive text by using simple present tense which influenced of interlanguage transfer and intralingual transfer.
Identification Of Determinats Influencing Consumer Decision-Making For Local and Imported Fruits Purchases in Manado City
Authors: Timban Aimar Ridel Saviola , Mandei Juliana Ruth , Jocom Sherly Gladys
Published: March 2024

This research aims to identify the determinants influencing consumer decision-making for local and imported fruits purchases in Manado City. The study was conducted over a period of 4 months, from June to September 2023. Primary data were collected through direct observation and interviews with respondents using a questionnaire. The data analysis used in this research is mixed-methods strategy. The sampling method utilized was accidental sampling over a 7-day period, resulting in a total of 60 respondents. The research findings indicate that the internal factor determining consumer decision-making for the purchase of local and imported fruits in the city of Manado is taste preference compatibility. Meanwhile, the external factor influencing consumer decision-making is the price and income compatibility for imported fruits and family member recommendations for local fruits. Taste preference compatibility emerges as the primary determinant in consumer decision-making for the purchase of both local and imported fruits in Manado City.
Pengaruh pemberian susu kedelai terhadap tekanan darah pasien hipertensi di Rumah Sakit Islam Jakarta Pondok Kopi
Authors: Handayani Felia , Yahya Gunarti , Darmawan Syarif , Fayasari Adhila
Published: March 2024

Latar belakang: Susu kedelai merupakan salah satu pangan fungsional yang mempunyai efek menurunkan tekanan darah. Hipertensi masih menjadi masalah utama di masyarakat karena berkaitan dengan resiko komplikasi penyakit kardiovaskuler.  Terdapat peningkatan angka kejadian penderita hipertensi di Rumah Sakit Islam Jakarta Pondok Kopi. Tujuan: Menganalisis pengaruh pemberian susu kedelai terhadap penurunan tekanan darah pada pasien hipertensi di RSI Jakarta Pondok Kopi. Metode : Penelitian ini menggunakan desain quasi eksperimental dengan pretest-posttest control group design, yang melibatkan 30 subjek (15 sampel perlakuan, 15 sampel kontrol) yang memiliki tekanan darah sistolik >140 mmHg dan diastolik >90 mmHg tanpa komplikasi. Kedua kelompok diberi perlakuan berupa pemberian obat hipertensi, cairan parenteral dan diet rendah natrium. Kelompok perlakuan diberikan susu kedelai sebanyak 2 x 250 cc selama 2 hari. Data asupan diukur dengan menggunakan recall 24 jam, status gizi diukur dengan konversi Indeks Massa Tubuh dan pengukuran tekanan darah menggunakan spyghmomanometer yang diukur oleh tenaga kesehatan. Analisis statistik menggunakan Independent t test dan paired t test untuk melihat efek perubahan tekanan darah kedua kelompok. Hasil : Terdapat perbedaan signifkan antara tekanan darah sebelum dan sesudah intervensi pada kedua kelompok (p<0,05), namun rata-rata tekanan darah diastolik pada perlakuan lebih besar daripada kelompok kontrol. Terdapat penurunan tekanan darah pada sampel perlakuan sistolik sebesar 15,5 mmHg dan diastolik10,6 mmHg pada kelompok perlakuan, selisih ini 2 kali lebih besar daripada selisih penurunan pada kelompok kontrol (sistolik 7,6 mmHg dan diastolik 3,5 mmHg). Kesimpulan : Pemberian susu kedelai secara signifkan dapat menurunkan tekanan darah sistolik dan diastolik pada pasien hipertensi.
Pengembangan Aplikasi Catering Pada Rumah Makan Berbasis Mobile
Authors: Jihad  , Fachrie Muhammad
Published: March 2024

Ordering catering is an activity carried out by customers to buy products in the form of food. At the Tebar Rasa Restaurant, the catering ordering process is carried out by customers by coming directly to the location. Based on the author's interviews with related parties, in the process of ordering catering there are several customers who complain about the ordering process because it takes more time, effort and costs. As a solution to this problem the authors built a Web and Mobile-Based Catering Order Application to assist in the process of ordering catering by customers. In making this application the author uses the android programming base and MySQL as the data storage. This application is made to streamline time, effort and produce accurate information. The results of testing the built application have performance according to user needs. By combining the advantages of the PHP and Java programming languages, this research has the potential to create a more efficient and satisfying food ordering experience for customers.
Pemasaran Digital dan Penataan Display Produk Pada Ritel Tradisional
Authors: Surahman Surahman , Salsabila Amanda Putri , Sari Anggun Regeta , Rouw Aquilda , Amalia Dini , Nurfadilla Sofi , Ulandari Vina
Published: March 2024

Conventional retail store is a retail business that sells convenience products in order to fulfill the people’s daily needs. However, with the presence of various e-commerce platforms, changing consumer behavior, and other technological developments, conventional retail stores need to adapt their business strategy to stay relevant and compete in the digital age by updating its performance digitally. The benefit is to reach wider customers and increase product accessibility. The aim of this survey is to analyze and provide solutions on what kind of strategy that a conventional retail store should do to upgrade its system to a semi-modern or modern retail store. This research uses qualitative methods to understand the phenomena in society related to conventional retail store that are facing the pressure of modernization. The data sources used are primary and secondary data sources. The data contained in this journal is collected by the interview technique to the store owner directly. The results of the research showed specifically the location, Toko Anggun merges into one with the home of the store owner and without a banner or special name board in front of it to introduce the identity or name of the store itself. The method of payment used is still traditional, and does not carry out promotional activities
Pelatihan Sitasi Karya Ilmiah Menggunakan Mendeley
Authors: Faharuddin Situju Sulfayanti , Nahya Nur  , Hamrul Heliawaty , Rasjid Nurdina , Dian Megah Sari
Published: March 2024

Writing of scientific paper is done by following specified rules and regulations. In reality there are many students at the Faculty of Engineering, University of Sulawesi Barat who do not understand this well, for example: not paraphrasing quotations and not including reference sources correctly. Mendeley application can help students in writing scientific papers or final assignments but it still underutilized by students. This shows the importance of reference citing skills and utilizing the Mendeley application. So, it is necessary to conduct scientific paper citation training. The training was done through planning, training and evaluation activities. Planning aims to prepare and determine the needs during the training. The main activity, training, was organized for two days using a webinar concept on the first day which focused on providing material for preparing scientific work references and a training concept on the second day which focused on practice using Mendeley and coaching research proposals. Last activity, an evaluation was carried out to measure the successfulness of the training and further plans related to similar activities. The results of the training activities showed the participation of 68 students on the first day and 36 students on the second day. The results of the survey showed 100% of students who participated in training felt the benefits of the training therefore they hoped similar activities could be held every year. Another evaluation result is that student supervision should be done in small groups, so the reception of material more effective regarding how to cite scientific papers.
РОЛЬ ШТУЧНОГО ІНТЕЛЕКТУ В СУЧАСНИХ СТРАТЕГІЯХ КІБЕРБЕЗПЕКИ: АНАЛІЗ ПОТЕНЦІЙНИХ ЗАГРОЗ ДЛЯ ЕЛЕКТРОННОГО БІЗНЕСУ
Authors: Шкоденко Т.
Published: March 2024

Штучний інтелект відіграє ключову роль у сучасних стратегіях кібербезпеки, особливо в контексті захисту електронного бізнесу. Загрози кібербезпеки стають все більш складними та небезпечними, оскільки хакери та зловмисники постійно вдосконалюють свої методи та атакують уразливі точки в мережах електронних ресурсів компаній.
АЛЬТЕРНАТИВНІ ДЖЕРЕЛА ЕНЕРГІЇ ДЛЯ СУДНОПЛАВСТВА: ОГЛЯД МОЖЛИВОСТЕЙ ТА ВИКЛИКІВ
Authors: Пуляєв Ігор , Щенявський Генадій , Заяц Сергій , Яременко Володимир
Published: March 2024

У статті розглядаються актуальні питання, пов'язані з викидами шкідливих речовин у вихлопних газах суднових двигунів, а також внесені зміни до Міжнародної конвенції щодо запобігання забрудненню з суден. Особлива увага приділяється альтернативним видам суднового палива та їхньому впливу на довкілля. Зазначається, що для ефективного впровадження нових видів палива необхідно враховувати різні аспекти, такі як безпека, регулювання, ціноутворення, доступність інфраструктури та інші. Підкреслюється, що більшість альтернативних палив уже застосовується на сучасних суднах, але при цьому, існують виклики і перешкоди для їхнього широкомасштабного впровадження.
CHALLENGES IN TRANSLATING MEDICAL TERMINOLOGY: A COMPREHENSIVE ANALYSIS OF ENGLISH-UKRAINIAN PHARMACEUTICAL TEXTS
Authors: Behdai Anastasiia , Gudkova Nataliia
Published: March 2024

The article examines the peculiarities of translating medical instructions from English into Ukrainian. The medical terms in the instructions for medicinal products were analyzed. The article emphasizes the necessity of the translator’s knowledge in the field of medical sciences, in particular, pharmacology, biochemistry, pharmaceutical chemistry. Problems that hinder the correct translation of medical instructions are emphasized, the main of which are difficulties in translating abbreviations, eponyms, synonyms, Latinisms, and Greekisms.