bluuebunny/crossref_metadata_2025 huggingface dataset:
A Biomechanical Evaluation of a Next-Generation Integrated and Modular ACDF Device Possessing Full-Plate, Half-Plate, and No-Profile Fixation Iterations
Authors: Panchal Ripul , Gandhi Anup , Ferry Chris , Farmer Sam , Hansmann Jeremy , Wanebo John
Published: March 2019

Study Design:

In vitro biomechanical study.

Objectives:

The objective of this in vitro biomechanical range-of-motion (ROM) study was to evaluate spinal segmental stability following fixation with a novel anterior cervical discectomy and fusion (ACDF) device (“novel device”) that possesses integrated and modular no-profile, half-plate, and full-plate fixation capabilities.

Methods:

Human cadaveric (n = 18, C3-T1) specimens were divided into 3 groups (n = 6/group). Each group would receive one novel device iteration. Specimen terminal ends were potted. Each specimen was first tested in an intact state, followed by anterior discectomy (C5/C6) and iterative instrumentation. Testing order: (1) novel device (group 1, no-profile; group 2, half-plate; group 3, full-plate); (2) novel device (all groups) with lateral mass screws (LMS); (3) traditional ACDF plate + cage; (4) traditional ACDF plate + cage + LMS. A 2 N·m moment was applied in flexion/extension (FE), lateral bending (LB), and axial rotation (AR) via a kinematic testing machine. Segmental ROM was tracked and normalized to intact conditions. Comparative statistical analyses were performed.

Results:

Key findings: (1) the novel half- and full-plate constructs provided comparable reduction in FE and LB ROM to that of traditional plated ACDF ( P ≥ .05); (2) the novel full-plate construct significantly exceeded all other anterior-only constructs ( P ≤ .05) in AR ROM reduction; and (3) the novel half-plate construct significantly exceeded the no-profile construct in FE ( P < .05).

Conclusions:

The novel ACDF device may be a versatile alternative to traditional no-profile and independent plating techniques, as it provides comparable ROM reduction in all principle motion directions, across all device iterations.
Factors Affecting Return to Play After Primary Achilles Tendon Tear: A Cohort of NFL Players
Authors: Yang JaeWon , Hodax Jonathan D. , Machan Jason T. , Krill Michael K. , Lemme Nicholas J. , Durand Wesley M. , Hoffman Joshua T. , Hewett Timothy E. , Owens Brett D.
Published: March 2019

Background:

Achilles tendon tears are potentially career-ending injuries for professional athletes. For players in the National Football League (NFL), return requires not only surgery and extensive rehabilitation but also the ability to compete in a market with limited positions that annually introduces new recruits.

Purpose/Hypothesis:

We authors sought to evaluate factors related to return to play (RTP) and changes in performance following a primary Achilles tear. Our hypothesis was that “skilled” position players and those drafted in later rounds would return at a lower rate as compared with “unskilled” position players and higher draft-round players.

Study Design:

Case-control study; Level of evidence, 3.

Methods:

From a previously established database, 80 NFL players were identified as having primary Achilles tendon tears between the 2009 and 2014 seasons. RTP was defined as playing in a regular season or postseason game following injury. Probability of RTP was modeled as a function of time after injury in Kaplan-Meier analysis with demographic variables assessed via generalized linear models. Twelve players (15%) experienced a subsequent Achilles tendon tear during or after the study period and were included in the overall RTP rate but were excluded from performance analyses owing to the confounding effects of an ipsilateral retear or contralateral tear.

Results:

The overall RTP rate was 61.3%. Age, number of prior seasons, position type, or draft round status did not significantly affect RTP when evaluated with Kaplan-Meier analysis. In the season before their injury, players who did RTP played in a significantly greater number of regular season games (13.7) compared with players who did not RTP (8.71) ( P = .011). Players who did not RTP exhibited a significant decrease in performance in the season preceding injury (12.7 regular season games played 2 seasons preinjury vs 8.71 regular season games played 1 season prior preinjury;, P = .019). Players who returned did not display a significant change in the number of games played or started in seasons following injury when >1 season after return was evaluated.

Conclusion:

Rate of RTP following primary Achilles tendon tears may be lower than previously published. However, for those able to return, performance only in the season immediately following injury appears to be affected; players return to preinjury levels if given the opportunity to play >1 season after injury.
Sharing knowledge for policy action in low- and middle-income countries: A literature review of managed entry agreements
Authors: Castro Hector E. , Malpica-Llanos Tanya , Musila Ruth , Konduri Niranjan , Amaris Ana , Sullivan Jennifer , Gilmartin Colin
Published: March 2019

Managed entry agreements (MEAs)—a type of formal institutional arrangement between pharmaceutical companies and payers for sharing the risk with respect to the introduction of new pharmaceutical technologies—may expand access to new pharmaceutical technologies for non-communicable diseases (NCDs). Although common in highincome countries (HICs), there is limited evidence of their use in low- and middle-income countries (LMICs). This article aims to document international experiences of countries implementing MEAs and potential barriers and facilitators for their use in LMICs. We reviewed published literature sources on MEAs over the past 10 years considering peer-reviewed publications and gray literature data. We took into consideration the MEAs taxonomy presented by Kanavos and Ferrario et al. to categorize our findings, and extract information on factors for their implementation. We retrieved 285 MEAs documented in the literature, mostly from HICs and for a broad spectrum of NCDs. Financial schemes were slightly more prominent than performance-based agreements. Identified factors that could potentially facilitate or hinder the implementation of MEAs included the presence of quality administrative and information systems to track their implementation; availability of quality data and evidence of positive outcomes; uncertainty of drug efficacy/effectiveness, safety, and financial impact; and cultural factors, namely country’s preference for certain type of agreement and trust among payers and manufacturers. The increased availability of publications in recent years suggests a growing interest among policy-makers and researchers in the implementation of MEAs. While the use of MEAs in LMICs is very limited, this could be the result of limited empirical evidence on its use and possibly due to the use of a different taxonomy for describing MEAs in these settings. As any other policy option, the implementation and use of MEAs come with advantages and challenges. Since there is limited evidence on their use in LMICs, the identified cases of implementation in HICs may serve to inform the interest on MEAs in resource limited settings. Therefore, further research in this field especially in the context of LMICs may be of value for the global community as all countries are embarking into fairer and sustainable Universal Health Coverage (UHC).
The perceived importance and objective measurement of walkability in the built environment rating
Authors: Zhang Xuan , Mu Lan
Published: March 2019

The built environment plays an important role in shaping physical activities and furthering a healthy lifestyle. An obesogenic environment, which promotes obesity through uninviting neighborhood design, can cause sedentary living and environmentally induced inactivity, particularly by reducing walking. Existing measures of walkability consider the distribution and features of potential destinations, but fail to account for key aspects of the built environment design, pedestrian preferences, or various reasons for walking. In this paper, we propose a new assessment method, the Perceived importance and Objective measurement of Walkability in the built Environment Rating (POWER), incorporating pedestrian preferences derived from a walking preference survey. By conducting a university campus-based case study, we developed a quantitative method, the customized analytic hierarchy process, to analyze data from the survey. The customized analytic hierarchy process was used to calculate the perceived importance of various factors. In addition, objective measurements were collected and processed from Geographic Information System (GIS) data and fieldwork. Using both perceived importance and objective measurements, we created a POWER map showing the most walkable and unwalkable places on campus. The outcome of this case study reveals the nuanced spatial variations with regard to walkability. The proposed integral measure creates an improved method for rating the walkability of the built environment. Future applications and limitations are also discussed.
Equal Opportunity in Education: A Perspective from Below
Authors: Chand Deep , Karre Sailu
Published: March 2019

The aim of this article is to contextualize the meaning of equal educational opportunities and its distributional pattern in Indian society from the perspective of justice. This article also attempts to answer the following questions: (a) The meaning of equal opportunities in education: for whom is the education intended? and (b) What is the pattern of educational distribution and inequalities in educational opportunities? Finally, the article also elaborates on the relationship between state, society and education; how the state favours certain ideologies which perpetuate the denial of education and create problematic situation for low-caste students in their access to educational institutions.
Wind parks in post-crisis Greece: Neoliberalisation vis-à-vis green grabbing
Authors: Siamanta Zoi Christina
Published: March 2019

This article explores the growth of wind parks in post-crisis Greece in the convergence of the Greek economic crisis, the country’s structural adjustment and global climate change. It illuminates an ongoing process of nature’s neoliberalisation defined by specific measures and strategies. These have facilitated a wave of green grabbing (public and private land, financial and natural resources) in Greece by mostly transnational (energy) companies. Green grabbing is leading to unfavourable consequences for local shepherds and farmers, domestic and small business electricity consumers, conservation and local biodiversity, as well as to ecological distribution conflicts. Private wind parks in post-crisis Greece serve as a socioecological fix to the Greek economic crisis and climate change. The article finally argues that large private and public-private wind parks are far from innocent. Rather, hiding under green and economic growth/recovery credentials, they represent a vehicle for the reproduction and expansion of capitalism with important socioecological implications varying in each context necessitating urgent empirical exploration.
Examining Public Communication About Kidney Cancer on Twitter
Authors: Sedrak Mina S. , Salgia Meghan M. , Decat Bergerot Cristiane , Ashing-Giwa Kemi , Cotta Brendan N. , Adashek Jacob J. , Dizman Nazli , Wong Andrew R. , Pal Sumanta K. , Bergerot Paulo Gustavo
Published: March 2019

PURPOSE

Several studies have described the content of Twitter conversations about lung, breast, and prostate cancer, but little is known about how the public uses Twitter to discuss kidney cancer. We sought to characterize the content of conversations on Twitter about kidney cancer and the participants engaged in these dialogues.

METHODS

This qualitative study analyzed the content of 2,097 tweets that contained the key words kidney cancer from August 1 to 22, 2017. Tweets were categorized by content domain of conversations related to kidney cancer on Twitter and user types of participants in these dialogues.

RESULTS

Among the 2,097 kidney cancer–related tweets analyzed, 858 (41.4%) were authored by individuals, 865 (41.2%) by organizations, and 364 (17.4%) by media sites. The most common content discussed was support (29.3%) and treatment (26.5%). Among the 2,097 tweets, 825 were unique tweets, and 1,272 were retweets. The most common unique tweets were about clinical trials (23.9%), most often authored by media sites. The most common retweets were about treatment (38.5%), most often authored by organizations.

CONCLUSION

Twitter dialogues about kidney cancer are most commonly related to support and treatment. Our findings provide insights that may inform the design of new interventions that use social media as a tool to improve communication of kidney cancer information. Additional efforts are needed to improve our understanding of the value and direct utility of social media in improving kidney cancer care.
Nonsurgical Management of Rectal Cancer
Authors: Akce Mehmet , El-Rayes Bassel F.
Published: March 2019

Neoadjuvant chemoradiotherapy followed by surgical resection is the standard of care for locally advanced rectal adenocarcinoma. Up to one third of patients achieve pathologic complete response (CR) with neoadjuvant therapy. Promising disease-free and overall survival outcomes have been reported in patients who achieve clinical CR after neoadjuvant therapy without surgical resection. Furthermore, patients who have local recurrence have acceptable disease control outcomes with salvage resection. With consideration of morbidities associated with surgical resection and similar clinical outcomes, interest in nonsurgical management of low rectal cancers has emerged. Randomized clinical trials are being conducted to evaluate a nonsurgical approach in rectal cancer. Lack of consensus on the definition of clinical CR, molecular biomarkers, and standardized nonsurgical management protocols is a significant barrier for routine clinical implementation of a nonsurgical management approach. This article aims to provide a concise review of the clinical experience and practical approach to the nonsurgical management of locoregional rectal adenocarcinoma.
Wheat Strip Effects on Microbial Transport Following Variable Applications of Beef Cattle Manure
Authors: Durso Lisa M. , Gilley John E. , Marx David B. , Thayer Chance A. , Woodbury Bryan L.
Published: March 2019

Abstract.

Vegetative filter strips (VFS) consisting of perennial vegetation have been successfully used to reduce the transport of contaminants in runoff from land application areas. The effectiveness of a winter wheat strip, which may be more acceptable to producers, in reducing microbial transport was examined in this study. A 1.4 m wheat strip was used to allow direct comparison with experimental results obtained in previous studies. Beef cattle manure was applied to 0.75 m wide by 4.0 m long plots established on an Aksarben silty clay loam located in southeast Nebraska. Manure was added at rates required to meet the 0- 1-, 2-, or 4-year phosphorus requirement for corn. The transport of selected microbes was measured for three 30 min simulated rainfall events separated by 24 h intervals. The narrow wheat strip did not significantly reduce counts of any of the measured microbes. The application of manure to meet the 4-year P requirement resulted in and enterococci loads that were significantly greater than the 1-year P requirement. Rainfall simulation run significantly affected measurements of phages, total coliforms, , and enterococci, with measurements during the three runs varying from 9.35 to 10.9 log plaque-forming units (PFU) ha-1, from 11.5 to 12.1 log colony-forming units (CFU) ha-1, from 12.1 to 12.5 log CFU ha-1, and from 11.1 to 11.4 log CFU ha-1, respectively. The transport of was found to be significantly correlated to selected nutrient loads and electrical conductivity of runoff. The presence of narrow wheat strips did not reduce microbial loads in runoff. Keywords: Bacteria, Cattle manure, E. coli, Filter strips, Land application, Manure management, Manure runoff, Microbial, Microorganisms, Runoff.
Feasibility of Immunosuppressant Drug Monitoring by a Microsampling Device
Authors: Gruzdys Valentinas , Merrigan Stephen D , Johnson-Davis Kamisha L
Published: March 2019

Background

Therapeutic drug monitoring (TDM) for immunosuppressive (ISP) drugs is an important component of organ and tissue transplantation and chemotherapy management. Whole blood is the specimen type for the quantitative analysis of cyclosporine A, everolimus, sirolimus, and tacrolimus. Some alternatives to venous whole blood samples have the potential to reduce blood volume requirements and simplify sample collection and transport.

Methods

The feasibility of ISP drug (cyclosporine A, everolimus, sirolimus, and tacrolimus) monitoring via microsampling device (MitraTM, Neoteryx) was assessed by comparing venous samples collected and extracted using microsampling device to conventional extraction procedure. Analysis was performed by LC-MS/MS.

Results

All analytes were found to be linear across the measurement range of 22.7–937.0 ng/mL (18.9–779.1 nmol/L) for cyclosporine A, 2.3–44.2 ng/mL (2.4–46.1 nmol/L) for everolimus, 2.2–47.2 ng/mL (2.4–51.6 nmol/L) for sirolimus, and 2.2–41.3 ng/mL (2.7–51.4 nmol/L) for tacrolimus. Imprecision was evaluated at concentrations within the therapeutic range and was found to be 10.1% and 5.8% for cyclosporine A, 10.0% and 10.0% for everolimus, 15.0% and 11.9% for sirolimus, and 6.8% and 8.5% for tacrolimus. Method comparison (n = 30 for each analyte, using Deming regression) indicated slopes of 1.08, 1.02, 0.90, and 1.15 and intercepts of −12.8 ng/mL (−10.7 nmol/L), 0.8 ng/mL (0.8 nmol/L), 1.5 ng/mL (1.7 nmol/L), and −0.3 ng/mL (−0.3 nmol/L) for cyclosporine A, everolimus, sirolimus, and tacrolimus, respectively.

Conclusions

This feasibility study demonstrates that precision and bias of ≤15% can be achieved for microsampling-based ISP monitoring.
Gestão Pública Educacional: A Importância da Afetividade no Processo Educativo Infantil / Public Educational Management: The Importance of Affectivity in the Children's Educational Process
Authors: Alencar Cláudio , Floriano Auriélia Coelho Isaque , Eugênio Aparecida Vieira Souza , Teles Inalda Maria De Sá Carvalho
Published: March 2019

A Educação Infantil é uma das fases do desenvolvimento humano que requer mais atenção e dedicação, tanto nos aspectos intelectual, emocional, social como motor da criança. O Objetivo do presente estudo foi discutir a importância da afetividade no desenvolvimento da criança, baseando-se sobre as concepções de Piaget, Wallon e Vygotsky acerca do desenvolvimento cognitivo e da afetividade. Concluiu-se que  a escola deve valorizar a criança e compreende-la em sua totalidade. Há uma indissociabilidade entre educar e cuidar, que deve ser valorizada, para que seja possível perceber a relação entre cognição e afetividade.
Uso ornamental de plantas de restinga
Authors: Freire Maria das Graças Machado , Mussi-Dias Vicente
Published: March 2019

Upstate Rio de Janeiro restingas remain an open field for research on both richness and conservation of species. However, once vegetation there lies in privileged coastal areas, it is constantly threatened by real estate and industrial speculation. The beauty of its flora calls attention and arises the desire to take some local species to urban areas. Thus, the objective of this work is to identify species of plants from the restinga ecosystem which could be suitable for pot planting for landscaping use. Thirty different species were planted in pots containing soil, sand and manure as substrate and maintained for a period of one year. Along this time, variables such as plant height, number of leaves and diameter of the stem base were obtained. It was possible to identify the characteristics of each plant in relation to its adaptation to the potting environment, as well as to obtain information that might help choose species to properly fit the desired purpose of use.
EVALUATION OF RAILWAY BALLAST LAYER CONSOLIDATION AFTER MAINTENANCE WORKS
Authors: Sysyn Mykola , Nabochenko Olga , Kovalchuk Vitalii , Gerber Ulf
Published: March 2019

The results of the study of the ballast layer consolidation after the work of ballast-tamping machines of different types are given in the article. The existing methods of determining the degree of consolidation of the ballast layer are analysed. The seismic method was improved by means of a complex dynamic and kinematic interpretation of the impulse response. For the dynamic interpretation with the use of statistical analysis, the features are selected so that they correspond to the degree of consolidation of the ballast layer. On the basis of researches, a device and software were developed that allow an automated evaluation of the ballast layer consolidation based on the kinematic and dynamic analysis of the measured impulse response. The measurements of the degree of the ballast layer consolidation after an operation of ballast-consolidation machines in different sequences allowed establishing the efficiency of the consolidation and the feasibility of the machines’ application.
One novel curcumin derivative ZYX01 induces autophagy of human non-small lung cancer cells A549 through AMPK/ULK1/Beclin-1 signaling pathway
Authors: Zhou Guang-Zhou , Wang Qing-Qing , Wang Peng-Bo , Wang Zhi-Chen , Sun Gang-Chun
Published: March 2019

Presently, curcumin derivatives had been paid more attention in view of their high bioavailability or water solubility, which herein possibly replaced the curcumin for their functional applications in future. Here, one novel chemically synthesized curcumin derivative, ZYX01, was used to identify anti-proliferation activity of human non-small lung cancer cells A549 and its anti-proliferative mechanism. Our study showed that ZYX01 could induce autophagic death of A549 cells by morphological observation, MTT assay, acridine orange staining and MDC assay, which possess a dose-and time-dependent manner. ZYX01-treated A549 cells possessed an increase in LC3-II/LC3-I ratio, upregulation of beclin-1 and downregulation of p62 expression. We further confirmed the cellular AMPK/ULK1/Beclin-1 signaling pathway in A549 cells after ZYX01 treatment. The anti-migration effect of ZYX01 in A549 cells was also explored by wound healing assay and transwell experiment. Current results had confirmed that ZYX01 induced A549 cells autophagy through AMPK/ULK1/Beclin-1 pathway and shed light on the future study on the anti-cancer molecular mechanism.
The effect of thymopentin add-on in hepatitis B e antigen positive chronic hepatitis B after virus suppression by peginterferon plus entecavir therapy
Authors: Ma Yanpin , Bao Xuli , Xiong Fang , Wang Jinhuan , Gu Na , Guo Jia , Wu Huili , Lu Jun
Published: March 2019

Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) was positively correlated with serological hepatitis B surface antigen (HBsAg) levels in hepatitis B e antigen (HBeAg) positive chronic hepatitis B (CHB) patients. We evaluated whether Thymopentin (TP5) and interferon (IFN-a) had a synergic effect on HBV cccDNA and the effect of TP5 addition therapy on HBsAg clearance in CHB patients. Real-time PCR experiments were performed to test cccDNA in HepG2.2.15 cells. 45 HBeAg-positive CHB patients had been distributed into two groups randomly. Treatment group: 23 patients were treated with a 24-week TP5 on the basis of the treatment entecavir (ETV) and peginterferon alfa-2a (PegIFN alpha-2a). Control group: 22 patients were treated with ETV and PegIFNa-2a. The study period was 72 weeks. In HepG2.2.15 cells, TP5 5ug/ml and 10ug/ml respectively combined with IFN-a 2ku/ml could potently inhibit cccDNA level at 72 hours (P<0.05). In clinical study, mean HBsAg levels in two groups are not significantly different at different time points (p=0.112). However, changes of mean HBsAg levels in TP5 add-on group at different time points are significantly different (p<0.05). Patients with HBsAg levels <1500IU/ml in control group had higher HBsAg levels compared with patients with HBsAg levels <1500IU/ml in TP5 add-on group (P=0.019). The latter had the most pronounced HBsAg reduction. TP5 and IFN had a synergic effect on inhibiting cccDNA levels in HepG2.2.15 cells; Patients in treatment group showed no extra side effects compared with the control group. 24 weeks TP5 add-on treatment was safe and had a tendency to accelerate the decline of HBsAg when HBV-DNA was undetectable.
Antioxidant and alpha amylase inhibitory activities of Fumaria officinalis and its antidiabetic potential against alloxan induced diabetes
Authors: Fatima Saba , Akhtar Muhammad Furqan , Ashraf Komal Maria , Sharif Ali , Saleem Ammara , Akhtar Bushra , Peerzada Sohaib , Shabbir Maryam , Ali Sajid , Ashraf Waseem
Published: March 2019

Fumaria officinalis belongs to family papaveraceae and is traditionally used to treat hypertension, hepatitis and diabetes. The current study was conducted to evaluate in vitro and in vivo antidiabetic activity of Fumaria officinalis. Aerial parts of the plant were sequentially extracted with n-hexane, chloroform, methanol and water. Phytochemical analysis was carried out on all extracts. Antioxidant activity was determined by 2,2-diphenyl-1-picryl hydrazyl (DPPH) inhibition method. In vitro alpha-amylase inhibitory activity was performed on all extracts by using dinitrosalicylic acid. Effect of aqueous and methanolic extracts of F. officinalis on blood glucose was evaluated in normo-glycaemic rats and alloxan induced diabetic rats. Glimepiride 0.2 mg/kg was used as standard therapy in diabetic rats. Results showed that methanolic extract exhibited the maximum percentage inhibition of DPPH (86.30%) and alpha-amylase inhibition (94.01%) at 500 µg/ml and 16 mg/ml concentration respectively. Administration in normo-glycaemic rats did not show any significant decrease in blood glucose level at 500 and 750 mg/kg dosage. Aqueous and methanolic extracts exhibited a significant hypoglycaemic effect (pË‚0.05) at all doses. A significant increase in the body weight and an improvement in liver and kidney function tests of diabetic rats were observed. These extracts also reduced the damage to the cells of glomeruli, interstitial inflammation, necrosis of tubular cells and thrombosis in the kidney, the enlargement of sinusoids and steatosis in the liver of diabetic rats. This study concludes that F. officinalis may have antidiabetic potential possibly due to its antioxidant and alpha-amylase inhibitory activities.
Seroprevalence and geographical distribution of hepatitis C virus in Iranian patients with thalassemia: a systematic review and meta-analysis
Authors: Shamshirian Amir , Alizadeh-Navaei Reza , Pourfathollah Ali Akbar , Alipoor Reza , Mohseni Ali Reza
Published: March 2019

Background

Thalassemia as a hereditary hemoglobinopathy is the most common monogenic disease worldwide. Patients with thalassemia require regular blood transfusion, which provides the risk for the transmission of hepatitis C virus (HCV) as the most common post-transfusion infection in such patients, and this rate is very diverse in different parts of the world. We aimed to determine the prevalence of HCV among patients with thalassemia in Iran.

Methods

In this study, we searched for articles on the prevalence of HCV among Iranian thalassemia patients in English and Persian databases up to 2017. Heterogeneities were assessed by using anI-square (I2) test. Prevalence and 95% confidence interval (CI) were calculated using the random effects model.

Results

In total, 37 studies with 9185 patients were included in the meta-analysis. The prevalence of HCV among Iranian thalassemia patients was 17.0% (95% CI: 14.5–19.8). The rate of prevalence among male and female subjects was 17.4% (95% CI: 13.8–21.9) and 16.8% (95% CI: 13.2–21.1), respectively.

Conclusions

We found that the prevalence of HCV among Iranian thalassemia patients declined over time and the Iranian Blood Transfusion Organization has had a reasonable performance in HCV screening.
Optimized Inventory Control on Construction Materials by Application of E-Technology Transfer along JIT
Authors: Harsha Vardhana Balaji , Venugopal Pulidindi
Published: March 2019

Most of the construction projects in India experience ineffective inventory control because of the application of the conventional method. This conventional procurement management method is commonly practiced (more than 95 % of the time), which encourages improper utilization of resources in construction industries. Material procurement is a financially operated arena that requires technology transfer rather than common techniques. Construction stakeholders are generally unaware of E-Technology development. Recent E-Technology commerce networking and communication has been drastically improved and thus can be effectively utilized to produce uninterrupted supply chain management in construction procurement systems; additionally, this technological transfer system in construction industries can improve the profit margins and can avoid time overrun of construction projects.
INDICADORES SOCIOAMBIENTAIS DO RIO DE JANEIRO: UMA ANÁLISE COMPARATIVA DO SANEAMENTO BÁSICO DA VIII REGIÃO HIDROGRÁFICA
Authors: De Souza Márcio Araújo , Pires Rachel Cristina Santos
Published: March 2019

Saneamento básico é um conjunto medidas que objetivam garantir a preservação ambiental. É possível por meio de serviços de abastecimento de água potável, esgotamento sanitário, tratamento de resíduos e drenagem. Normalmente oriundos de serviços que podem ser prestados por empresas públicas ou, em regime de concessão, por empresas privadas. Com base na série histórica de 2015 e Indicadores de Água e Esgoto, oriundos do Sistema Nacional de Informações sobre Saneamento (SNIS), este estudo objetiva utilizar esses dados para comparar os municípios que pertencem à mesma região hidrográfica no Rio de Janeiro. As análises serão expressas em linguagens porcentuais a fim de comparar os indicadores regionais da VIII Região hidrográfica (RH). Será também realizada uma comparação da região estudada frente às médias encontradas para o sudeste e para o Brasil para cada indicador, permitindo assim uma discussão com base nos dados publicados sobre o diagnóstico dos Serviços de Água e Esgotos do Sistema Nacional de Informações sobre Saneamento no Brasil, referente ao último ano de publicação.
Informações Editoriais
Authors: Farias Bruno Matos de , Avelar Katia Eliane Santos
Published: March 2019

Informações Editoriais
A Human TRPA1-Specific Pain Model
Authors: Heber Stefan , Gold-Binder Markus , Ciotu Cosmin I. , Witek Martin , Ninidze Nino , Kress Hans-Georg , Fischer Michael J.M.
Published: March 2019

The cation channel transient receptor potential ankyrin 1 (TRPA1) plays an important role in sensing potentially hazardous substances. However, TRPA1 species differences are substantial and limit translational research. TRPA1 agonists tested previously in humans also have other targets. Therefore, the sensation generated by isolated TRPA1 activation in humans is unknown. The availability of 2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)-acetamide (JT010), a potent and specific TRPA1 agonist, allowed us to explore this issue. To corroborate the specificity of JT010, it was investigated whether the TRPA1 antagonist (1E,3E)-1-(4-fluorophenyl)-2-methyl-1-penten-3-one oxime (A-967079) abolishes JT010-elicited pain. Sixteen healthy volunteers of both sexes rated pain due to intraepidermal injections of different concentrations and combinations of the substances. The study design was a double-blind crossover study. All subjects received all types of injections, including a placebo without substances. Injections of the TRPA1 agonist dose-dependently caused pain with a half-maximal effective concentration of 0.31 μm. Coinjection of A-967079 dose-dependently reduced and at a high concentration abolished JT010-induced pain. Quantification of JT010 by HPLC showed that a substantial part is adsorbed when in contact with polypropylene surfaces, but that this was overcome by handling in glass vials and injection using glass syringes. Isolated TRPA1 activation in humans causes pain. Thus, intradermal JT010 injection can serve as a tool to validate new TRPA1 antagonists concerning target engagement. More importantly, TRPA1-specific tools allow quantification of the TRPA1-dependent component in physiology and pathophysiology.

SIGNIFICANCE STATEMENTThis study showed that activation of the ion channel transient receptor potential ankyrin 1 (TRPA1) alone indeed suffices to elicit pain in humans, independent of other receptors previously found to be involved in pain generation. The newly established TRPA1-specific pain model allows different applications. First, it can be tested whether diseases are associated with compromised or exaggerated TRPA1-dependent painful sensations in the skin. Second, it can be investigated whether a new, possibly systemically applied drug directed against TRPA1 engages its target in humans. Further, the general possibility of quantitative inhibition of TRPA1 allows identification of the TRPA1-dependent disease component, given that the substance reaches its target. This contributes to a better understanding of pathophysiology, can lay the basis for new therapeutic approaches, and can bridge the gap between preclinical research and clinical trials.
On Apples and Anarchy
Authors: Falvo Kathryn R.
Published: March 2019

In the summer of 1843, eleven reformers in Massachusetts embarked upon a doomed utopian experiment called “Fruitlands.” Their object was to create a perfect society, devoid of the negative influences of capitalism, trade, and government. They planned on doing so through rigorous adherence to strict communal regulations, among which was strict veganism. This article argues that the Fruitlands experiment—though a failure—is instructive because it provides a detailed example of one particular articulation of the tie between veganism and anarchism. Unlike more modern reformers, the Fruitlanders stressed hierarchy (rather than equality) between humans and animals. Rejecting the animal world was crucial for them as they attempted to become perfect beings, eligible for utopia. Fruitlands thus showcases the way that the vegan-anarchic tie has been profoundly different in each of its incarnations, and therefore an illustrative lens into the political and social world of the nineteenth century.
The Hansik Globalization Campaign: A Malaysian Critique
Authors: Khoo Gaik Cheng
Published: March 2019

This article critiques the South Korean government's strategies to globalize Korean cuisine (hansik) for its First World bias and for overlooking important dynamics that are operating locally. In particular the discourse as expressed on the Korean Food Foundation website demonstrates this desire to be accepted by the West and to be on par with Japan. Based on interviews with Korean restaurant owners in Malaysia and a survey of Malaysian diners, I argue for an emphasis on the role that Korean migrants play in inadvertently promoting hansik as part of the gastrodiplomatic negotiations in line with their processes of adaptation and settlement in Malaysia.
Bad Fathers: The Patricide Theme in Three Short Stories by Nguyễn Huy Thiệp (1987–1990)
Authors: Thi Doan Cam
Published: March 2019

In “The General Retires,” “Without a King,” and “Crime and Punishment,” three short stories written between 1987 and 1990 by Nguyễn Huy Thiệp, the authoritative father figure is omnipresent. Whether an army dignitary, a modest bicycle repairer, or a humble farmer, these fathers all have difficult relationships with their children—relationships which, although not devoid of love or affection, suffer from grudges, conflict, and hate. These fathers call their sons cowards, set them against each other, and rape their daughters. But their death at the end of each story is systematic. The plots within the stories present the father as a species threatened with extinction and even likely to be assassinated by his own children. This paper on the literature at the beginning of the Renovation [Đổi Mới] offers a reading of the theme of patricide in the work of Nguyễn Huy Thiệp as an indication of profound ideological crisis and as a metaphor for the keen desire for change.
Sunday
Authors: To Matthew
Published: March 2019

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Medicine, Make-up, & Male Perspectives
Authors: George Sheenagh
Published: March 2019

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Sans peur et sans reproche: A history of the General Public Hospital in Saint John
Authors: Wong Mike
Published: March 2019

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The Effect of Aspirin as an Irreversible COX1 Inhibitor in Preventing Non-Valvular Atrial Fibrillation After Coronary Bypass Surgery
Authors: Erkut Bilgehan , Ates Azman
Published: March 2019

Background: We investigated whether the use of aspirin (irreversible COX1 inhibitor) in the preoperative period may prevent non-valvular atrial fibrillation, which is the most common rhythm problem in the postoperative period. Non-valvular atrial fibrillation after coronary surgery may lead to an increase in hospital costs due to excessive drug use and long-term hospitalization.
Methods: More than 1000 coronary artery bypass grafting operations were performed between January 2011 to and Nov 2018. The 572 patients were included in this study. Patients were divided into two groups as medication (n=292) and medication-free group (n=280). In the medication group, while patients received aspirin (300 mg daily) therapy (up to 5 days) before the operation, the other group did not receive any anti-aggregan treatment. The patients were followed up for the occurrence of atrial fibrillation from the early postoperative period up to 3 months.
Results: While non-valvular atrial fibrillation was developed in 16 patients (5,5 %) in medication group, this rate was 24,3 % with 68 patients in medication-free group 3 month after operation (P < .05). In addition to the intensive care unit and hospital stay, there was a significant difference between the groups in terms of hospital costs (P < .05).
Conclusions: According to the results of our study, we found that the aspirin used in preoperative period may prevent non-valvular atrial fibrillation in the postoperative period. In relation to these results; we found that hospital stay and hospital expenses decreased.
Obecność cudownego wizerunku Matki Bożej Łaskawej ze Lwowa w Tarnowie i wątki tarnowskie w biografii abp. Eugeniusza Baziaka
Authors: Soprych Jacek
Published: March 2019

Liczne związki abp. Eugeniusza Baziaka z Tarnowem, szczególnie jego zaufanie do pasterza diecezji bp. Jana Stepy, pozwoliły na złożenie w depozycie dwóch najcenniejszych skarbów metropolii lwowskiej – srebrnej trumienki z relikwiami bł. Jakuba Strzemię oraz obrazu Matki Bożej Łaskawej. Wizerunek Matki Bożej z lwowskiej katedry łacińskiej jest dla Polaków szczególną narodową pamiątką. To przed nim 1 kwietnia 1656 roku król Jan Kazimierz ślubował bronić wiary katolickiej i praw ludu, a Maryję obrał Królową Korony Polskiej. Po drugiej wojnie światowej zmieniły się granice naszej ojczyzny i Lwów pozostał poza nią. Arcybiskup Baziak wywiózł tę ważną relikwię do Polski. Nie mógł zostawić tak wielkiego skarbu. Nie mógł narażać go na profanację czy zniszczenie. Tarnów stał się ważnym przystankiem, gdzie przez wiele lat ukrywany był ten cenny wizerunek.
Charakterystyczne cechy egzegezy Pisma Świętego św. Tomasza z Akwinu
Authors: Michalik Andrzej
Published: March 2019

Święty Tomasz z Akwinu był nie tylko znakomitym filozofem i teologiem, ale także niestrudzonym egzegetą Pisma Świętego. Spod jego pióra wyszły komentarze zarówno do ksiąg Starego, jak i Nowego Testamentu. Egzegeza św. Tomasza z Akwinu odznacza się kilkoma cechami. Jest to egzegeza oparta na dwóch fundamentalnych regułach: analogii wiary katolickiej i analogii wiary biblijnej. Ponadto posiada także charakterystyczny dla całej egzegezy średniowiecznej rys scholastyczny, patrystyczny i teologiczny.
Szczególnie zasłużeni dla nauki i kultury. Doktorzy honoris causa Uniwersytetu Papieskiego Jana Pawła II w Krakowie w latach 2015–2018
Authors: Stala Józef
Published: March 2019

Doktor honoris causa jest stopniem akademickim przyznawanym komuś, kto miał szczególny wkład w rozwój określonej dyscypliny, społeczeństwa lub Kościoła. W latach 2015–2018 doktorat honoris causa Uniwersytetu Papieskiego Jana Pawła II w Krakowie otrzymali: Profesor Elie Wiesel – 30 czerwca 2015, Papież Benedykt XVI – 3 lipca 2015, Arcybiskup Celestino Migliore – 16 października 2015, Ksiądz Professor Michał Heller – 22 czerwca 2016, Kardynał Profesor Gerhard Ludwig Müller – 16 października 2017, Profesor Rémi Brague – 11 stycznia 2018. W niniejszym artykule są przedstawione wszystkie osoby docenione przez Uniwersytet Papieski Jana Pawła II w Krakowie za wysiłki na rzecz pokojowego rozwiązywania konfliktów na całym świecie poprzez promowanie międzywyznaniowego dialogu, zrozumienie, wnikliwą inteligencję oraz ich znaczący wkład na rzecz Kościoła.
Autopercepción de las reclusas reincidentes en una cárcel colombiana y su relación con el crimen
Authors: Paba Barbosa Carmelina , Ortega Pacheco Yesid José , Campillo Gómez Maira Alejandra , Hernández Bolívar Michael Fabián , Martínez Ruda Milena , Porto Corredor Daniela Marcela
Published: March 2019

Con el objetivo de conocer por primera vez cuál es la autopercepción de las reclusas reincidentes en una cárcel colombiana y su relación con el crimen, se realizó metodológicamente un estudio de naturaleza cualitativa con un diseño fenomenológico. La información se obtuvo de entrevistas semiestructuradas aplicadas a la población de estudio y codificada a través del software Atlas.ti., los datos arrojados sustentan su validez gracias a la técnica triangulación de la información donde intervienen estos últimos, lo arrojado a la luz de la teoría y lo hallado por los investigadores. Los resultados muestran que las convictas no se auto conciben como delincuentes y que esta no tiene relación directa con los actos delincuenciales.
The Green Dividend Dilemma: Carbon Dividends Versus Double-Dividends
Authors: Fried Stephie , Novan Kevin , Peterman William
Published: March 2019

By raising the price of carbon-emitting energy sources, a carbon tax would flexibly incentivize households and businesses to reduce fossil fuel consumption and substitute towards cleaner energy sources. A carbon tax would also generate a substantial stream of government revenue. This raises an important question – how should this revenue be used? In this note, we summarize findings from our recent research (Fried et al. (2018)) that examine this question.
Literatura: um estudo de caso da leitura dos clássicos brasileiros no Ensino Médio
Authors: Peron Eliza Da Silva Martins , Sampaio Emílio Davi
Published: March 2019

Este artigo apresenta o resultado de uma pesquisa realizada em duas escolas localizadas no município de Dourados - MS sobre a leitura dos romances clássicos. Com o objetivo de preservarmos a identidade das instituições, denominamos as escolas como A e B, sendo que a escola A pertence à rede pública de ensino e a escola B à rede privada. Como método de investigação, aplicamos questionários com questões fechadas e abertas aos alunos do terceiro ano do ensino médio. Este material nos permitiu uma abordagem da situação atual da leitura dos romances clássicos. A partir desses dados e, pautados em alguns estudiosos do tema, foi possível descrever a realidade de forma ampla a fim de evidenciar o que esses jovens leitores, estudantes do ensino médio, têm a nos dizer, sobre suas leituras ou não leituras dos romances clássicos brasileiros.
Possibilidades para a inclusão de literatura (não canônica) no ensino médio: Me llamo Rigoberta Menchú y así me nació la conciencia na sala de aula
Authors: Zolin-Vesz Fernando , Santos Sandra Leite dos
Published: March 2019

O intuito deste artigo é propor possibilidades em que a obra Me llamo Rigoberta Menchú y así me nació la conciencia, publicada em 1985 por Elizabeth Burgos, oportunize o ensino de literatura na educação básica por um viés não canônico. Coadunando com a proposta de Grosfoguel (2008) em deslocar o lócus de enunciação do homem europeu para as mulheres indígenas das Américas, a exemplo de Rigoberta Menchú, e visando a abarcar literaturas ainda pouco estudadas na educação básica, dispõe-se, desse modo, a construir perspectivas para a problematização de aspectos da vida social, particularmente situações de exclusão e de injustiças sociais que o processo de colonialidade ainda insiste em perpetuar.
Monte Carlo Simulation 4 Stages wind Turbine v1
Authors: Hai Pham Manh , Nguyen The-Vinh
Published: March 2019

This is methodology and data of our research on Monte Carlo Simulation of generations (included traditional sources and wind turbine). In addition, the wind turbine is simulated in four states and the traditional generators are simulated as in the RTS System of IEEE. In data folder, we supply the real data of four wind turbine from an industrial plant (don't show its name cause by its own reason). This data folder includes two .xlsx files corresponding two wind turbine. That shows all values of active power in two years of each wind turbine with the sample time of 10 minutes. We also supply the matlab code file (.m file) to extrange with other researchers. However, Protocol System don't accept the extended file ".m", thus, we saved it in .txt file. It has three .txt files according diffirent case studies. The file named by "RTS System" is used to check the ogirinal RTS System version 1979. The files named by "reliability" and "Wind turbine Generators 4 states" are correspond to 4 Scenarios not or with Wind turbine as in the manuscript. The RTS System is described in the paper "IEEE-RTS-1979" and the four states simulation of wind turbine is shown in the other paper (included by the .pdf file)
Yenilikçi finansman aracı olarak ekosistem hizmetleri için ödemeler: Fırsat mı, tehdit mi?
Authors: KAYA Güven
Published: March 2019

Orman kaynaklarının topluma sağladığı biyolojik çeşitliliği barındırma, estetik hizmetler, su ve toprak koruma, yaban hayatını barındırma gibi ekosistem hizmetlerinin üretimi için geleneksel anlamda pazar teşviki bulunmamaktadır. Son on yılda dünyada ekosistemlerin yönetiminde en popüler kavramlardan biri, ekosistem hizmetlerinin devamlılığını güvence altına almak için yenilikçi finansman araçlarını içeren, İngilizce kısaltması PES (payment for ecosystem services) olarak bilinen ekosistem hizmetleri için ödemelerdir. Ekosistem hizmetleri için ödeme programlarının habitat kullanma hakları, koruma irtifakları ve imtiyazları, korunan alanları kiralama, ticari karbon, biyolojik çeşitlilik, havza koruma kredileri gibi çeşitli türleri bulunmaktadır. Bazıları ekosistem hizmetleri için ödeme programlarını orman ekosistemlerinin korunması için kurtarıcı olarak görürken karşıt görüştekilere göre ise ekosistem hizmetleri için ödeme programları kamu mallarının ticarileştirilerek tüketilmesi için bir araç olarak yeni pazarlar yaratma yollarından biridir. Bu makalede dünya ve Türkiye ölçeğinde ekosistem hizmetleri için ödeme programlarının orman ekosistemlerinin sürdürülebilir yönetimi açısından fırsat ve tehdit oluşturduğu koşullar irdelenmiş, kullanım olanakları değerlendirilmiştir.
"Pois só se questiona o que se conhece!": entrevista com Maria de Deus Beites Manso
Authors: Santana Geferson , França Junior Edevard Pinto , Santos Fabrício Lyrio
Published: March 2019

Apresentamos a entrevista concedida pela historiadora portuguesa Maria de Deus Beites Manso, que é especialista nos estudos em torno da história do Império Português. Publicou diversos artigos e livros, dentro e fora de seu país de origem, que dialogam com diversas temáticas como as questões raciais, mulheres e relações de gênero, escravidão e história indígena, mas sua publicação recente é a obra História da Companhia de Jesus de Portugal (Editora Parsifal, 2016). Nas linhas que seguem, deixaremos que a própria entrevistada comente sobre sua trajetória intelectual e sua circulação pelos diversos espaços de sociabilidade do além-mar.