bluuebunny/crossref_metadata_2025 huggingface dataset:
Lewis Acid Properties of Tetrel Tetrafluorides—The Coincidence of the σ-Hole Concept with the QTAIM Approach
Authors: Grabowski Sławomir
Published: February 2017

Tetrel bond is analysed for a series of ZF4 (Z = C, Si, Ge) complexes with one and two NH3 or AsH3 ligands. The MP2/aug-cc-pVTZ calculations were performed and supported by results of the Quantum Theory of “Atoms in Molecules” (QTAIM) and the Natural Bond Orbitals (NBO) approaches. The Z-tetrel atoms of complexes analysed interact through their σ-holes with nitrogen or arsenic Lewis base centres; these interactions correspond to the Z…N/As bond paths according to the QTAIM approach. The QTAIM and NBO results show that these interactions are relatively strong and they possess numerous characteristics of covalent bonds. The theoretical analysis is supported by the discussion on crystal structures which are characterized by the same type interactions.
Review of the Magnetocaloric Effect in RMnO3 and RMn2O5 Multiferroic Crystals
Authors: Balli Mohamed , Roberge Benoit , Fournier Patrick , Jandl Serge
Published: February 2017

It is known that some of RMnO3 and RMn2O5 (R = rare earth) multiferroic crystals reveal a strong interplay between their magnetic and electric order parameters, paving the way for applications in spintronic technologies. Additionally, recent works have also pointed out their potential utilization as refrigerants in magnetocaloric cooling systems for cryogenic tasks. In this paper, recent advances regarding the magnetocaloric properties of both RMnO3 and RMn2O5 families of multiferroics are reviewed. With the aim of understanding the RMnO3 and RMn2O5 magnetocaloric features, their structural and magnetic properties are discussed. The physics behind the magnetocaloric effect as well as some of its key thermodynamic aspects are also considered.
Site Identity and Importance in Cosubstituted Bixbyite In2O3
Authors: Rickert Karl , Harris Jeremy , Sedefoglu Nazmi , Kavak Hamide , Ellis Donald , Poeppelmeier Kenneth
Published: February 2017

The bixbyite structure of In2O3 has two nonequivalent, 6-coordinate cation sites and, when Sn is doped into In2O3, the Sn prefers the “b-site” and produces a highly conductive material. When divalent/tetravalent cation pairs are cosubstituted into In2O3, however, the conductivity increases to a lesser extent and the site occupancy is less understood. We examine the site occupancy in the MgxIn2−2xSnxO3 and ZnxIn2−2xSnxO3 systems with high resolution X-ray and neutron diffraction and density functional theory computations, respectively. In these sample cases and those that are previously reported in the MxIn2−2xSnxO3 (M = Cu, Ni, or Zn) systems, the solubility limit is greater than 25%, ensuring that the b-site cannot be the exclusively preferred site as it is in Sn:In2O3. Prior to this saturation point, we report that the M2+ cation always has at least a partial occupancy on the d-site and the Sn4+ cation has at least a partial occupancy on the b-site. The energies of formation for these configurations are highly favored, and prefer that the divalent and tetravalent substitutes are adjacent in the crystal lattice, which suggests short range ordering. Diffuse reflectance and 4-point probe measurements of MgxIn2−xSnxO3 demonstrate that it can maintain an optical band gap >2.8 eV while surpassing 1000 S/cm in conductivity. Understanding how multiple constituents occupy the two nonequivalent cation sites can provide information on how to optimize cosubstituted systems to increase Sn solubility while maintaining its dopant nature, achieving maximum conductivity.
Designs: A Multidisciplinary Open-Access Engineering Journal
Authors: Karimi Hamid
Published: February 2017

I am honored to serve as the Editor-in-Chief of the new journal of Designs.[...]
On-Line Junction Temperature Monitoring of Switching Devices with Dynamic Compact Thermal Models Extracted with Model Order Reduction
Authors: Di Napoli Fabio , Magnani Alessandro , Coppola Marino , Guerriero Pierluigi , D’Alessandro Vincenzo , Codecasa Lorenzo , Tricoli Pietro , Daliento Santolo
Published: February 2017

Residual lifetime estimation has gained a key point among the techniques that improve the reliability and the efficiency of power converters. The main cause of failures are the junction temperature cycles exhibited by switching devices during their normal operation; therefore, reliable power converter lifetime estimation requires the knowledge of the junction temperature time profile. Since on-line dynamic temperature measurements are extremely difficult, in this work an innovative real-time monitoring strategy is proposed, which is capable of estimating the junction temperature profile from the measurement of the dissipated powers through an accurate and compact thermal model of the whole power module. The equations of this model can be easily implemented inside a FPGA, exploiting the control architecture already present in modern power converters. Experimental results on an IGBT power module demonstrate the reliability of the proposed method.
An Experimental Study on the Thermal Performance of Phase-Change Material and Wood-Plastic Composites for Building Roofs
Authors: Chung Min , Park Jin
Published: February 2017

We assessed the usefulness of phase-change material (PCM)-based thermal plates fabricated from wood-plastic composites (WPCs) in mitigating the urban heat island effect. The thermal performance of plates containing PCMs with two different melting temperatures and with two different albedo levels was evaluated. The results showed that the PCM with a melting temperature of 44 °C maintained lower surface and inner temperatures than the PCM with a melting temperature of 25 °C. Moreover, a higher surface albedo resulted in a lower surface temperature. However, the thermal performance of PCMs with different melting temperatures but the same surface albedo did not differ. Using PCM-based materials in roof finishing materials can reduce surface temperatures and improve thermal comfort.
Energy Conservation in an Office Building Using an Enhanced Blind System Control
Authors: Carrascal-Lekunberri Edorta , Garrido Izaskun , Heijde Bram , Garrido Aitor , Sala José , Helsen Lieve
Published: February 2017

The two spaces office module is usually considered as a representative case-study to analyse the energetic improvement in office buildings. In this kind of buildings, the use of a model predictive control (MPC) scheme for the climate system control provides energy savings over 15% in comparison to classic control policies. This paper focuses on the influence of solar radiation on the climate control of the office module under Belgian weather conditions. Considering MPC as main climate control, it proposes a novel distributed enhanced control for the blind system (BS) that takes into account part of the predictive information of the MPC. In addition to the savings that are usually achieved by MPC, it adds a potential 15% improvement in global energy use with respect to the usually proposed BS hysteresis control. Moreover, from the simulation results it can be concluded that the thermal comfort is also improved. The proposed BS scheme increases the energy use ratio between the thermally activated building system (TABS) and air-handling unit (AHU); therefore increasing the use of TABS and allowing economic savings, due to the use of more cost-effective thermal equipment.
Assessing Precision in Conventional Field Measurements of Individual Tree Attributes
Authors: Luoma Ville , Saarinen Ninni , Wulder Michael , White Joanne , Vastaranta Mikko , Holopainen Markus , Hyyppä Juha
Published: February 2017

Forest resource information has a hierarchical structure: individual tree attributes are summed at the plot level and then in turn, plot-level estimates are used to derive stand or large-area estimates of forest resources. Due to this hierarchy, it is imperative that individual tree attributes are measured with accuracy and precision. With the widespread use of different measurement tools, it is also important to understand the expected degree of precision associated with these measurements. The most prevalent tree attributes measured in the field are tree species, stem diameter-at-breast-height (dbh), and tree height. For dbh and height, the most commonly used measuring devices are calipers and clinometers, respectively. The aim of our study was to characterize the precision of individual tree dbh and height measurements in boreal forest conditions when using calipers and clinometers. The data consisted of 319 sample trees at a study area in Evo, southern Finland. The sample trees were measured independently by four trained mensurationists. The standard deviation in tree dbh and height measurements was 0.3 cm (1.5%) and 0.5 m (2.9%), respectively. Precision was also assessed by tree species and tree size classes; however, there were no statistically significant differences between the mensurationists for dbh or height measurements. Our study offers insights into the expected precision of tree dbh and height as measured with the most commonly used devices. These results are important when using sample plot data in forest inventory applications, especially now, at a time when new tree attribute measurement techniques based on remote sensing are being developed and compared to the conventional caliper and clinometer measurements.
The Welfare Cost of Signaling
Authors: Yang Fan , Harstad Ronald
Published: February 2017

Might the resource costliness of making signals credible be low or negligible? Using a job market as an example, we build a signaling model to determine the extent to which a transfer from an applicant might replace a resource cost as an equilibrium method of achieving signal credibility. Should a ﬁrm’s announcement of hiring for an open position be believed, the ﬁrm has an incentive to use a properly-calibrated fee to implement a separating equilibrium. The result is robust to institutional changes, outside options, many ﬁrms or many applicants and applicant risk aversion, though a sufﬁciently risk-averse applicant who is sufﬁciently likely to be a high type may lead to a preference for a pooling equilibrium.
Topological Aspects of the Multi-Language Phases of the Naming Game on Community-Based Networks
Authors: Palombi Filippo , Toti Simona
Published: February 2017

The Naming Game is an agent-based model where individuals communicate to name an initially unnamed object. On a large class of networks continual pairwise interactions lead the system to an ultimate consensus state, in which agents onverge on a globally shared name. Soon after the introduction of the model, it was observed in literature that on community-based networks the path to consensus passes through metastable multi-language states. Subsequently, it was proposed to use this feature as a mean to discover communities in a given network. In this paper we show that metastable states correspond to genuine multi-language phases, emerging in the thermodynamic limit when the fraction of links connecting communities drops below critical thresholds. In particular, we study the transition to multi-language states in the stochastic block model and on networks with community overlap. We also xamine the scaling of critical thresholds under variations of topological properties of the network, such as the number and relative size of communities and the structure of intra-/inter-community links. Our results provide a theoretical justification for the proposed use of the model as a community-detection algorithm.
OJ 287 as a Rotating Helix
Authors: Cohen Marshall
Published: February 2017

We present preliminary data from high-cadence 15-GHz VLBA images of OJ 287 from 1995 to 2015. The ridgelines suggest that the jet is rotating, perhaps with a period of∼30 years. The EVPA of the core rotated by 240° in 2001–2002 and decreased slowly after that. The inner jet apparently moved to a new direction after the rotation,as shown by the emergence of a new component at a new PA at 43 GHz, in 2004. This was presaged by a strong rise in the ﬂux density of the core, and then its sudden fall as the new component was identiﬁed. The equivalent sequence of events took place about 5 years later at 15 GHz, but in addition the core EVPA had a step in 2006 and moved to be aligned with the new 43-GHz component. The 15-GHz core became optically thin in 2006, but the angular resolution was insufﬁcient to separate the new component from the core until 2010
In Vivo Imaging of Local Gene Expression Induced by Magnetic Hyperthermia
Authors: Sandre Olivier , Genevois Coralie , Garaio Eneko , Adumeau Laurent , Mornet Stéphane , Couillaud Franck
Published: February 2017

The present work aims to demonstrate that colloidal dispersions of magnetic iron oxide nanoparticles stabilized with dextran macromolecules placed in an alternating magnetic field can not only produce heat, but also that these particles could be used in vivo for local and noninvasive deposition of a thermal dose sufficient to trigger thermo-induced gene expression. Iron oxide nanoparticles were first characterized in vitro on a bio-inspired setup, and then they were assayed in vivo using a transgenic mouse strain expressing the luciferase reporter gene under transcriptional control of a thermosensitive promoter. Iron oxide nanoparticles dispersions were applied topically on the mouse skin or injected subcutaneously with Matrigel™ to generate so-called pseudotumors. Temperature was monitored continuously with a feedback loop to control the power of the magnetic field generator and to avoid overheating. Thermo-induced luciferase expression was followed by bioluminescence imaging 6 h after heating. We showed that dextran-coated magnetic iron oxide nanoparticle dispersions were able to induce in vivo mild hyperthermia compatible with thermo-induced gene expression in surrounding tissues and without impairing cell viability. These data open new therapeutic perspectives for using mild magnetic hyperthermia as noninvasive modulation of tumor microenvironment by local thermo-induced gene expression or drug release.
AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models
Authors: Albert Katrina , Voutilainen Merja , Domanskyi Andrii , Airavaara Mikko
Published: February 2017

Gene delivery using adeno-associated virus (AAV) vectors is a widely used method to transduce neurons in the brain, especially due to its safety, efficacy, and long-lasting expression. In addition, by varying AAV serotype, promotor, and titer, it is possible to affect the cell specificity of expression or the expression levels of the protein of interest. Dopamine neurons in the substantia nigra projecting to the striatum, comprising the nigrostriatal pathway, are involved in movement control and degenerate in Parkinson′s disease. AAV-based gene targeting to the projection area of these neurons in the striatum has been studied extensively to induce the production of neurotrophic factors for disease-modifying therapies for Parkinson′s disease. Much less emphasis has been put on AAV-based gene therapy targeting dopamine neurons in substantia nigra. We will review the literature related to targeting striatum and/or substantia nigra dopamine neurons using AAVs in order to express neuroprotective and neurorestorative molecules, as well as produce animal disease models of Parkinson′s disease. We discuss difficulties in targeting substantia nigra dopamine neurons and their vulnerability to stress in general. Therefore, choosing a proper control for experimental work is not trivial. Since the axons along the nigrostriatal tract are the first to degenerate in Parkinson′s disease, the location to deliver the therapy must be carefully considered. We also review studies using AAV-a-synuclein (a-syn) to target substantia nigra dopamine neurons to produce an α-syn overexpression disease model in rats. Though these studies are able to produce mild dopamine system degeneration in the striatum and substantia nigra and some behavioural effects, there are studies pointing to the toxicity of AAV-carrying green fluorescent protein (GFP), which is often used as a control. Therefore, we discuss the potential difficulties in overexpressing proteins in general in the substantia nigra.
Phenology of a Vegetation Barrier and Resulting Impacts on Near-Highway Particle Number and Black Carbon Concentrations on a School Campus
Authors: Fuller Christina , Carter David , Hayat Matthew , Baldauf Richard , Watts Hull Rebecca
Published: February 2017

Traffic-related air pollution is a persistent concern especially in urban areas where populations live in close proximity to roadways. Innovative solutions are needed to minimize human exposure and the installation of vegetative barriers shows potential as a method to reduce near-road concentrations. This study investigates the impact of an existing stand of deciduous and evergreen trees on near-road total particle number (PNC) and black carbon (BC) concentrations across three seasons. Measurements were taken during spring, fall and winter on the campus of a middle school in the Atlanta (GA, USA) area at distances of 10 m and 50 m from a major interstate highway. We identified consistent decreases in BC concentrations, but not for PNC, with increased distance from the highway. In multivariable models, hour of day, downwind conditions, distance to highway, temperature and relative humidity significantly predicted pollutant concentrations. The magnitude of effect of these variables differed by season, however, we were not able to show a definitive impact of the vegetative barrier on near-road concentrations. More detailed studies are necessary to further examine the specific configurations and scenarios that may produce pollutant and exposure reductions.
Oxidative Stress-Related Genetic Variants May Modify Associations of Phthalate Exposures with Asthma
Authors: Wang I-Jen , Karmaus Wilfried
Published: February 2017

Background: Phthalate exposure may increase the risk of asthma. Little is known about whether oxidative-stress related genes may alter this association. First, this motivated us to investigate whether genetic polymorphisms of the oxidative-stress related genes glutathione S-transferase Mu 1 (GSTM1), glutathione S-transferase pi 1 (GSTP1), superoxide dismutase 2 (SOD2), catalase (CAT), myeloperoxidase (MPO), and EPHX1 in children are associated with phthalate urine concentrations. Second, we addressed the question whether these genes may affect the influence of phthalates on asthma. Methods: In a case-control study composed of 126 asthmatic children and 327 controls, urine phthalate metabolites (monoethyl phthalate (MEP), monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), and mono(2-ethyl-5-hydroxyhexyl)phthalate (MEHHP) were measured by UPLC-MS/MS at age 3. Genetic variants were analyzed by TaqMan assay. Information on asthma and environmental exposures was also collected. Analyses of variance and logistic regressions were performed. Results: Urine MEHHP levels were associated with asthma (adjusted OR 1.33, 95% CI (1.11–1.60). Children with the GSTP1 (rs1695) AA and SOD2 (rs5746136) TT genotypes had higher MEHHP levels as compared to GG and CC types, respectively. Since only SOD2 TT genotype was significantly associated with asthma (adjusted OR (95% CI): 2.78 (1.54–5.02)), we estimated whether SOD2 variants modify the association of MEHHP levels and asthma. As MEHHP concentrations were dependent on GSTP1 and SOD2, but the assessment of interaction requires independent variables, we estimated MEHHP residuals and assessed their interaction, showing that the OR for SOD2 TT was further elevated to 3.32 (1.75–6.32) when the residuals of MEHHP were high. Conclusions: Urine phthalate metabolite concentrations are associated with oxidative-stress related genetic variants. Genetic variants of SOD2, considered to be reflect oxidative stress metabolisms, might modify the association of phthalate exposure with asthma.
Prevalence of Tobacco Smoking and Determinants of Success in Quitting Smoking among Patients with Chronic Diseases: A Cross-Sectional Study in Rural Western China
Authors: Fu Hang , Feng Da , Tang Shangfeng , He Zhifei , Xiang Yuanxi , Wu Tailai , Wang Ruoxi , Shao Tian , Liu Chunyan , Shao Piaopiao , Feng Zhanchun
Published: February 2017

Abstract: Tobacco use is one of the behavioral risk factors for chronic diseases. The aim of the study was to investigate smoking prevalence in chronically ill residents and their smoking behavior in western rural China, to identify factors associated with success in quitting smoking, and to provide appropriate intervention strategies for tobacco control. Cross-sectional survey data from patients with chronic diseases from rural western China were analyzed. Among the 906 chronically ill patients, the current smoking prevalence was 26.2%. About 64.3% of smokers with chronic diseases attempted to quit smoking, 21.0% of which successfully quitted. The odds ratio (OR) of smokers with only one chronic disease to quit smoking successfully was higher than that of those who have other diseases (OR = 2.037, 95% confidence interval (CI) = 1.060-3.912; p < 0.05). The smokers who were always restricted to smoking in public places were more likely to quit smoking successfully than those who were free to smoke (OR = 2.188, 95% CI = 1.116–4.291; p < 0.05). This study suggests that health literacy, comorbidity of diseases, and psychological counseling should be considered when developing targeted tobacco prevention strategies. Strengthening tobacco control measures in public places such as rural medical institutions will be effective.
Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis
Authors: Huang Shi-Qi , Zhang Na , Zhou Zi-Xing , Huang Chui-Can , Zeng Cheng-Li , Xiao Di , Guo Cong-Cong , Han Ya-Jing , Ye Xiao-Hong , Ye Xing-Guang , Ou Mei-Ling , Zhang Bao-Huan , Liu Yang , Zeng Eddy , Yang Guang , Jing Chun-Xia
Published: February 2017

Background: Lipoma preferred partner (LPP) and T-cell activation Rho GTPase activating protein (TAGAP) polymorphisms might influence the susceptibility to celiac disease. Therefore, we performed a meta-analysis by identifying relevant studies to estimate the risks of these polymorphisms on celiac disease. Methods: The PubMed, Web of Science and Embase databases were searched (up to October 2016) for LPP rs1464510 and TAGAP rs1738074 polymorphisms. Results: This meta-analysis included the same 7 studies for LPP rs1464510 and TAGAP rs1738074. The minor risk A allele at both rs1464510 and rs1738074 carried risks (odds ratios) of 1.26 (95% CI: 1.22–1.30) and 1.17 (95% CI: 1.14–1.21), respectively, which contributed to increased risks in all celiac disease patients by 10.72% and 6.59%, respectively. The estimated lambdas were 0.512 and 0.496, respectively, suggesting that a co-dominant model would be suitable for both gene effects. Conclusions: This meta-analysis provides robust estimates that polymorphisms in LPP and TAGAP genes are potential risk factors for celiac disease in European and American. Prospective studies and more genome-wide association studies (GWAS) are needed to confirm these findings, and some corresponding molecular biology experiments should be carried out to clarify the pathogenic mechanisms of celiac disease.
Capital Markets, Infrastructure Investment and Growth in the Asia Pacific Region
Authors: Regan Michael
Published: February 2017

This paper examines the relationship between infrastructure investment activity, capital market development, the role of public institutions and economic development in the Asia Pacific. It adopts a review approach drawing on empirical evidence over recent decades. Infrastructure is shown to be an important asset class playing a central role in a nation’s output, growth, productivity and microeconomic performance. Infrastructure investment also requires investment and predictions of a widening gap in the future supply of infrastructure in the Asia Pacific will require new forms of capital from both traditional and new sources including wider use of private participation, institutional investment, asset recycling and revenue bonds. Capital market development is also necessary to raise long-term local currency finance and evidence suggests that progress with regional capital market integration is slow and a continuing reform agenda is required. The dividend for regional countries is the prospect of higher levels of economic growth with infrastructure investment, capital market development, and foreign direct investment shown to have a strong and positive association with growth. A crucial link in this association identified in the review is the part played by national and regional institutions in improving the efficiency with which infrastructure is managed and providing promising ground for further research where the importance of these links can be researched in greater depth.
Valproate Attenuates Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells via the AKT/GSK3β Signaling Pathway
Authors: Li Zhengmao , Wu Fenzan , Zhang Xie , Chai Yi , Chen Daqing , Yang Yuetao , Xu Kebin , Yin Jiayu , Li Rui , Shi Hongxue , Wang Zhouguang , Li Xiaokun , Xiao Jian , Zhang Hongyu
Published: February 2017

Endoplasmic reticulum (ER) stress-induced apoptosis plays an important role in a range of neurological disorders, such as neurodegenerative diseases, spinal cord injury, and diabetic neuropathy. Valproate (VPA), a typical antiepileptic drug, is commonly used in the treatment of bipolar disorder and epilepsy. Recently, VPA has been reported to exert neurotrophic effects and promote neurite outgrowth, but its molecular mechanism is still unclear. In the present study, we investigated whether VPA inhibited ER stress and promoted neuroprotection and neuronal restoration in SH-SY5Y cells and in primary rat cortical neurons, respectively, upon exposure to thapsigargin (TG). In SH-SY5Y cells, cell viability was detected by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay, and the expression of ER stress-related apoptotic proteins such as glucose‑regulated protein (GRP78), C/EBP homologous protein (CHOP), and cleaved caspase-12/-3 were analyzed with Western blot analyses and immunofluorescence assays. To explore the pathway involved in VPA-induced cell proliferation, we also examined p-AKT, GSK3β, p-JNK and MMP-9. Moreover, to detect the effect of VPA in primary cortical neurons, immunofluorescence staining of β-III tubulin and Anti-NeuN was analyzed in primary cultured neurons exposed to TG. Our results demonstrated that VPA administration improved cell viability in cells exposed to TG. In addition, VPA increased the levels of GRP78 and p-AKT and decreased the levels of ATF6, XBP-1, GSK3β, p-JNK and MMP-9. Furthermore, the levels of the ER stress-induced apoptosis response proteins CHOP, cleaved caspase-12 and cleaved caspase-3 were inhibited by VPA treatment. Meanwhile, VPA administration also increased the ratio of Bcl-2/Bax. Moreover, VPA can maintain neurite outgrowth of primary cortical neurons. Collectively, the neurotrophic effect of VPA is related to the inhibition of ER stress-induced apoptosis in SH-SY5Y cells and the maintenance of neuronal growth. Collectively, our results suggested a new approach for the therapeutic function of VPA in neurological disorders and neuroprotection.
The Role of Inhaled Loxapine in the Treatment of Acute Agitation in Patients with Psychiatric Disorders: A Clinical Review
Authors: De Berardis Domenico , Fornaro Michele , Orsolini Laura , Iasevoli Felice , Tomasetti Carmine , De Bartolomeis Andrea , Serroni Nicola , Valchera Alessandro , Carano Alessandro , Vellante Federica , Marini Stefano , Piersanti Monica , Perna Giampaolo , Martinotti Giovanni , Di Giannantonio Massimo
Published: February 2017

Loxapine is a first generation antipsychotic, belonging to the dibenzoxazepine class. Recently, loxapine has been reformulated at a lower dose, producing an inhaled powder that can be directly administered to the lungs to treat the agitation associated with psychiatric disorders, such as schizophrenia and bipolar disorder. Thus, the aim of this narrative and clinical mini-review was to evaluate the efficacy and tolerability of inhaled loxapine in the treatment of acute agitation in patients with psychiatric disorders. The efficacy of inhaled loxapine has been evaluated in one Phase II trial on patients with schizophrenia, and in two Phase III trials in patients with schizophrenia and bipolar disorder. Moreover, there are two published case series on patients with borderline personality disorder and dual diagnosis patients. Inhaled loxapine has proven to be effective and generally well tolerated when administered to agitated patients with schizophrenia and bipolar disorder. Two case series have suggested that inhaled loxapine may also be useful to treat agitation in patients with borderline personality disorder and with dual diagnosis, but further studies are needed to clarify this point. However, the administration of inhaled loxapine requires at least some kind of patient collaboration, and is not recommended in the treatment of severe agitation in totally uncooperative patients. Moreover, the drug-related risk of bronchospasm must always be kept in mind when planning to use inhaled loxapine, leading to a careful patient assessment prior to, and after, administration. Also, the higher costs of inhaled loxapine, when compared to oral and intramuscular medications, should be taken into account when selecting it for the treatment of agitation.
Twist2 Is Upregulated in Early Stages of Repair Following Acute Kidney Injury
Authors: Grunz-Borgmann Elizabeth , Nichols LaNita , Wang Xinhui , Parrish Alan
Published: February 2017

The aging kidney is a marked by a number of structural and functional changes, including an increased susceptibility to acute kidney injury (AKI). Previous studies from our laboratory have shown that aging male Fischer 344 rats (24 month) are more susceptible to apoptosis-mediated injury than young counterparts. In the current studies, we examined the initial injury and early recovery phases of mercuric chloride-induced AKI. Interestingly, the aging kidney had decreased serum creatinine compared to young controls 1 day following mercuric chloride injury, but by day 4, serum creatinine was significantly elevated, suggesting that the aging kidney did not recover from injury. This conclusion is supported by the findings that serum creatinine and kidney injury molecule-1 (Kim-1) gene expression remain elevated compared to young controls at 10 days post-injury. To begin to elucidate mechanism(s) underlying dysrepair in the aging kidney, we examined the expression of Twist2, a helix-loop-helix transcription factor that may mediate renal fibrosis. Interestingly, Twist2 gene expression was elevated following injury in both young and aged rats, and Twist2 protein expression is elevated by mercuric chloride in vitro.
Chitosan-Recombinamer Layer-by-Layer Coatings for Multifunctional Implants
Authors: Govindharajulu Jeevan , Chen Xi , Li Yuping , Rodriguez-Cabello Jose , Battacharya Mrinal , Aparicio Conrado
Published: February 2017

The main clinical problems for dental implants are (1) formation of biofilm around the implant—a condition known as peri-implantitis and (2) inadequate bone formation around the implant—lack of osseointegration. Therefore, developing an implant to overcome these problems is of significant interest to the dental community. Chitosan has been reported to have good biocompatibility and anti-bacterial activity. An osseo-inductive recombinant elastin-like biopolymer (P-HAP), that contains a peptide derived from the protein statherin, has been reported to induce biomineralization and osteoblast differentiation. In this study, chitosan/P-HAP bi-layers were built on a titanium surface using a layer-by-layer (LbL) assembly technique. The difference in the water contact angle between consecutive layers, the representative peaks in diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), X-ray photoelectron spectroscopy (XPS), and the changes in the topography between surfaces with a different number of bi-layers observed using atomic force microscopy (AFM), all indicated the successful establishment of chitosan/P-HAP LbL assembly on the titanium surface. The LbL-modified surfaces showed increased biomineralization, an appropriate mouse pre-osteoblastic cell response, and significant anti-bacterial activity against Streptococcus gordonii, a primary colonizer of tissues in the oral environment
Assessment of Trichogramma japonicum and T. chilonis as Potential Biological Control Agents of Yellow Stem Borer in Rice
Authors: Tang Rui , Babendreier Dirk , Zhang Feng , Kang Min , Song Kai , Hou Mao-Lin
Published: February 2017

Two species of Trichogramma wasps were assessed for their effectiveness against yellow stem borer Scirpophaga incertulas. A laboratory cage test with T. japonicum and T. chilonis showed that both species parasitized yellow stem borer egg masses at 60.0% ± 9.13% and 40.7% ± 7.11%, respectively, with egg parasitism rates of 15.8% ± 22.2% for T. japonicum and 2.8% ± 5.0% for T. chilonis. Once the host eggs were parasitized, emergence rates were high for both species (95.7% ± 0.12% for T. japonicum and 100% for T. chilonis). In paddy field trials, the two Trichogramma species were released at three densities (50,000/ha, 100,000/ha and 200,000/ha) in Southwestern China. Egg mass parasitism was 9% ± 7.7% for T. japonicum and 15% ± 14.1% for T. chilonis, and again only a relatively small fraction of eggs was successfully parasitized. No clear conclusion could be drawn on the most efficient release rate as no significant differences were found among the three release rates. A comparison of field-collected T. japonicum with T. japonicum and T. chilonis mass reared on Corcyra cephalonica showed significantly larger body size and ovipositor length in field-collected wasps, suggesting potentially higher effectiveness on yellow stem borer eggs after at least one generation on the target host. Factors contributing to the low field parasitism rates are discussed.
Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP)
Authors: Zufferey Anne , Kapur Rick , Semple John
Published: February 2017

Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by low platelet counts. The pathogenesis of ITP remains unclear although both antibody‐mediated and/or T cell‐mediated platelet destruction are key processes. In addition, impairment of T cells, cytokine imbalances, and the contribution of the bone marrow niche have now been recognized to be important. Treatment strategies are aimed at the restoration of platelet counts compatible with adequate hemostasis rather than achieving physiological platelet counts. The first line treatments focus on the inhibition of autoantibody production and platelet degradation, whereas second‐line treatments include immunosuppressive drugs, such as Rituximab, and splenectomy. Finally, thirdline treatments aim to stimulate platelet production by megakaryocytes. This review discusses the pathophysiology of ITP and how the different treatment modalities affect the pathogenic mechanisms.
A Novel Design Flow for a Security-Driven Synthesis of Side-Channel Hardened Cryptographic Modules
Authors: Huss Sorin , Stein Oliver
Published: February 2017

Over the last few decades, computer-aided engineering (CAE) tools have been developed and improved in order to ensure a short time-to-market in the chip design business. Up to now, these design tools do not yet support an integrated design strategy for the development of side-channel-resistant hardware implementations. In order to close this gap, a novel framework named AMASIVE (Adaptable Modular Autonomous SIde-Channel Vulnerability Evaluator) was developed. It supports the designer in implementing devices hardened against power attacks by exploiting novel security-driven synthesis methods. The article at hand can be seen as the second of the two contributions that address the AMASIVE framework. While the first one describes how the framework automatically detects vulnerabilities against power attacks, the second one explains how a design can be hardened in an automatic way by means of appropriate countermeasures, which are tailored to the identified weaknesses. In addition to the theoretical introduction of the fundamental concepts, we demonstrate an application to the hardening of a complete hardware implementation of the block cipher PRESENT.
Creep Rupture of the Simulated HAZ of T92 Steel Compared to that of a T91 Steel
Authors: Peng Yu-Quan , Chen Tai-Cheng , Chung Tien-Jung , Jeng Sheng-Long , Huang Rong-Tan , Tsay Leu-Wen
Published: February 2017

The increased thermal efficiency of fossil power plants calls for the development of advanced creep-resistant alloy steels like T92. In this study, microstructures found in the heat-affected zone (HAZ) of a T92 steel weld were simulated to evaluate their creep-rupture-life at elevated temperatures. An infrared heating system was used to heat the samples to 860 °C (around AC1), 900 °C (slightly below AC3), and 940 °C (moderately above AC3) for one minute, before cooling to room temperature. The simulated specimens were then subjected to a conventional post-weld heat treatment (PWHT) at 750 °C for two hours, where both the 900 °C and 940 °C simulated specimens had fine grain sizes. In the as-treated condition, the 900 °C simulated specimen consisted of fine lath martensite, ferrite subgrains, and undissolved carbides, while residual carbides and fresh martensite were found in the 940 °C simulated specimen. The results of short-term creep tests indicated that the creep resistance of the 900 °C and 940 °C simulated specimens was poorer than that of the 860 °C simulated specimens and the base metal. Moreover, simulated T92 steel samples had higher creep strength than the T91 counterpart specimens.
Analysis of the Influence of Starting Materials and Processing Conditions on the Properties of W/Cu Alloys
Authors: Montealegre-Meléndez Isabel , Arévalo Cristina , Perez-Soriano Eva , Neubauer Erich , Rubio-Escudero Cristina , Kitzmantel Michael
Published: February 2017

In this work, a study of the influence of the starting materials and the processing time used to develop W/Cu alloys is carried out. Regarding powder metallurgy as a promising fabrication route, the difficulties in producing W/Cu alloys motivated us to investigate the influential factors on the final properties of the most industrially demanding alloys: 85-W/15-Cu, 80-W/20-Cu, and 75-W/25-Cu alloys. Two different tungsten powders with large variation among their particle size—fine (Wf) and coarse (Wc) powders—were used for the preparation of W/Cu alloys. Three weight ratios of fine and coarse (Wf:Wc) tungsten particles were analyzed. These powders were labelled as “tungsten bimodal powders”. The powder blends were consolidated by rapid sinter pressing (RSP) at 900 °C and 150 MPa, and were thus sintered and compacted simultaneously. The elemental powders and W/Cu alloys were studied by optical microscopy (OM) and scanning electron microscopy (SEM). Thermal conductivity, hardness, and densification were measured. Results showed that the synthesis of W/Cu using bimodal tungsten powders significantly affects the final alloy properties. The higher the tungsten content, the more noticeable the effect of the bimodal powder. The best bimodal W powder was the blend with 10 wt % of fine tungsten particles (10-Wf:90-Wc). These specimens present good values of densification and hardness, and higher values of thermal conductivity than other bimodal mixtures.
Modeling of Processing-Induced Pore Morphology in an Additively-Manufactured Ti-6Al-4V Alloy
Authors: Kabir Mohammad , Richter Henning
Published: February 2017

A selective laser melting (SLM)-based, additively-manufactured Ti-6Al-4V alloy is prone to the accumulation of undesirable defects during layer-by-layer material build-up. Defects in the form of complex-shaped pores are one of the critical issues that need to be considered during the processing of this alloy. Depending on the process parameters, pores with concave or convex boundaries may occur. To exploit the full potential of additively-manufactured Ti-6Al-4V, the interdependency between the process parameters, pore morphology, and resultant mechanical properties, needs to be understood. By incorporating morphological details into numerical models for micromechanical analyses, an in-depth understanding of how these pores interact with the Ti-6Al-4V microstructure can be gained. However, available models for pore analysis lack a realistic description of both the Ti-6Al-4V grain microstructure, and the pore geometry. To overcome this, we propose a comprehensive approach for modeling and discretizing pores with complex geometry, situated in a polycrystalline microstructure. In this approach, the polycrystalline microstructure is modeled by means of Voronoi tessellations, and the complex pore geometry is approximated by strategically combining overlapping spheres of varied sizes. The proposed approach provides an elegant way to model the microstructure of SLM-processed Ti-6Al-4V containing pores or crack-like voids, and makes it possible to investigate the relationship between process parameters, pore morphology, and resultant mechanical properties in a finite-element-based simulation framework.
Band Gap Tuning in 2D Layered Materials by Angular Rotation
Authors: Polanco-Gonzalez Javier , Carranco-Rodríguez Jesús , Enríquez-Carrejo José , Mani-Gonzalez Pierre , Domínguez-Esquivel José , Ramos Manuel
Published: February 2017

We present a series of computer-assisted high-resolution transmission electron (HRTEM) simulations to determine Moiré patters by induced twisting effects between slabs at rotational angles of 3°, 5°, 8°, and 16°, for molybdenum disulfide, graphene, tungsten disulfide, and tungsten selenide layered materials. In order to investigate the electronic structure, a series of numerical simulations using density functional methods (DFT) methods was completed using Cambridge serial total energy package (CASTEP) with a generalized gradient approximation to determine both the band structure and density of states on honeycomb-like new superlattices. Our results indicated metallic transitions when the rotation approached 8° with respect to each other laminates for most of the two-dimensional systems that were analyzed.
Investigating the Effects of Loading Factors on the In Vitro Pharmaceutical Performance of Mesoporous Materials as Drug Carriers for Ibuprofen
Authors: Lai Junmin , Lin Wu , Scholes Peter , Li Mingzhong
Published: February 2017

The aim of the study was to investigate the effects of the loading factors, i.e., the initial drug loading concentration and the ratio of the drug to carriers, on the in vitro pharmaceutical performance of drug-loaded mesoporous systems. Ibuprofen (IBU) was used as a model drug, and two non-ordered mesoporous materials of commercial silica Syloid® 244FP (S244FP) and Neusilin® US2 (NS2) were selected in the study. The IBU-loaded mesoporous samples were prepared by a solvent immersion method with a rotary evaporation drying technique and characterized by polarized light microscopy (PLM), Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC). Dissolution experiments were performed in simulated gastric media at 37 °C under non-sink conditions. The concentration of IBU in solution was determined by HPLC. The study showed that the dissolution rate of IBU can be improved significantly using the mesoporous S224FP carriers due to the conversion of crystalline IBU into the amorphous form. Both of the loading factors affected the IBU dissolution kinetics. Due to the molecular interaction between the IBU and NS2 carriers, the loading factors had little effects on the drug release kinetics with incomplete drug desorption recovery and insignificant dissolution enhancement. Care and extensive evaluation must therefore be taken when mesoporous materials are chosen as carrier delivery systems.
Successful Pregnancy after Treatment with Chinese Herbal Medicine in a 43‐Year‐Old Woman with Diminished Ovarian Reserve and Multiple Uterus Fibrosis: A Case Report
Authors: Teng Benqi , Peng Jie , Ong Madeleine , Qu Xianqin
Published: February 2017

Objective: To highlight a natural approach to coexisting oligomenorrhea, subfertility, luteal phase insufficiency and multiple fibroids cohesively when in vitro fertilisation (IVF) has failed. Case Presentation: A 43‐year‐old woman with diminished ovarian reserve and multiple uterine fibroids had previously been advised to discontinue IVF treatment. According to Chinese Medicine diagnosis, herbal formulae were prescribed for improving age‐related ovarian insufficiency as well as to control the growth of fibroids. After 4 months of treatment, the patient’s menstrual cycle became regula r and plasma progesterone one week after ovulation increased from 10.9 nmol/L to 44.9 nmol/L. After 6 months, she achieved a natural conception, resulting in a live birth of a healthy infant at an estimated gestational age of 40 weeks. Conclusions: The successful treatment with Chinese Herbal Medicine for this case highlights a natural therapy to manage infertility due to ovarian insufficiency and multiple fibroids after unsuccessful IVF outcome.
Discussion on the Local Magnetic Force between Reversely Magnetized Micro Metal Particles in the Microwave Sintering Process
Authors: Xiao Yu , Xu Feng , Dong Bo , Liu Wenchao , Hu Xiaofang
Published: February 2017

Synchrotron radiation computed tomography was applied to investigate Cu–Fe mixture microwave sintering in situ and to examine the magnetic force between reversely magnetized micro-metal particles in microwave sintering. Results revealed that the growth rate of the sintering necks between Cu–Fe particles and Cu–Cu particles around the iron particles distributed in a vertical direction was faster than that of the sintering necks in the horizontal direction. These phenomena were consistent with the possible influence caused by the magnetic force between metal particles, as shown in our simple particle model. The kinetic curves of sintering neck growth along the vertical and horizontal directions quantitatively revealed the difference in growth rates. The contributing factors of magnetic force in microwave sintering were subsequently discussed. The volume of iron particles was proportional to the influence of magnetic force, and their shape elicited a remarkable influence based on demagnetization effects. This study provided a useful basis for microwave sintering mechanisms and anisotropic material preparation.
Effect of the Welding Speed on the Macrostructure, Microstructure and Mechanical Properties of AA6061-T6 Friction Stir Butt Welds
Authors: Fadaeifard Firouz , Matori Khamirul , Abd Aziz Sidek , Zolkarnain Liyana , Abdul Rahim Mohd
Published: February 2017

Friction stir welding of aluminum alloys has been progressively used in different industries on the ground of higher welding quality in comparison to fusion welding. In this article, friction stir welding of 6061-T6 aluminum alloy with 9.6 mm thickness was carried out by using three different welding speeds (63, 89 and 110 mm/min). The effect of welding speed on macro- and microstructure, micro hardness, tensile properties and kissing bond was investigated. Results show that the Low Hardness Zone was moved toward the weld center by increasing the welding speed. The average micro hardness in the weld nugget zone increased from 60.1 to 67.6 HV with the raise of welding speed from 63 to 110 mm/min. Thermo Mechanical Affected Zone was clearly revealed using Electron backscatter diffraction (EBSD). The kissing bond was studied by Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray (EDX) mapping. It was proven that the damaging effect of kissing bond was linked to location of this discontinuity, although the growth of kissing bond was linked to higher welding speed. The maximum value of Ultimate Tensile Strength (UTS) (159 MPa) was obtained at 110 mm/min, whereas the Yield Strength (YS) in the sample at 89 and 110 mm/min welding speed exhibit the same trend with 137 MPa and 134 MPa respectively.