bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Content Validation of End of Treatment Questionnaires for Children With Cancer
Authors: Conway Keller Mary , Ruiz Tiffany , Needham Andrew , King Courtney , Hart Leigh , Holden Elizabeth , Lucas Ruth
Published: October 2019

Purpose: To describe the development and content validation of measures to assess the psychoeducational needs of children, adolescents/young adults (AYAs), and their parents at the end of successful treatment for cancer. Method: Professional experts, which included pediatric oncology nurses and advanced practice registered nurses, conducted a systematic review of the literature to determine specific end of treatment (EOT) needs of children and AYAs with cancer and their parents and evaluate available tools to measure these needs. From this review, two EOT questionnaires were initially developed. Oncology Family Advisory Board (FAB) members served as experiential experts in refining and validating these questionnaires. FAB members participated in a content validation process, rating questionnaires online, and subsequently participating in a focus group to establish content validity ( n = 6). Results: Three EOT questionnaires were ultimately developed. The Child/AYA questionnaire was divided into two separate measures for developmental and literacy considerations. The Parent/Caregiver and the AYA questionnaires each contain 38 items with a content validity index score of 100%. The Child questionnaire contains 37 items with a content validity index score of 100%. Conclusion: Content validity was established for three EOT questionnaires, each of which has the potential to elicit information regarding needs and potential gaps in services perceived by childhood cancer survivors and their parents. Further psychometric testing is needed to determine stability (test–retest reliability) and construct validity of the questionnaires.
Nursing Process Addressing the Nursing Focus “Hallucination”: A Scoping Review
Authors: Gonçalves Patrícia Daniela Barata , Sampaio Francisco Miguel Correia , da Cruz Sequeira Carlos Alberto , Paiva e Silva Maria Antónia Taveira da Cruz
Published: October 2019

Although hallucinations are prevalent in psychiatric disorders, such as psychosis or dementia, no studies were to be found in literature about the nursing process addressing the focus “Hallucination”. This literature review, which is integrated with a scoping study framework, was performed to determine a clinical data model addressing the focus “Hallucination”. PRISMA checklist for scoping reviews was followed. From the total of 328 papers found, 32 were selected. The findings of this review were summarized according to the nursing process addressing the focus “Hallucination”. These findings led to determine a clinical data model addressing the focus “Hallucination”, comprising the elements of the nursing process. This clinical data model may contribute toward improving nursing decision-making and nursing care quality in relation to a client suffering from hallucination, as well as contribute toward producing more reliable nursing-sensitive indicators.
Gender and Foreign Policy: Are Female Members of Congress More Dovish than Their Male Colleagues?
Authors: Bendix William , Jeong Gyung-Ho
Published: October 2019

Research shows that female legislators tend to support liberal, pacifistic approaches to foreign policy. But it remains unclear whether they are dovish because they seek to represent the dovish values of women generally or because they tend to represent mostly liberal voters. To answer this question, we examine all foreign policy votes cast in Congress over the last five decades to estimate the ideological locations of House and Senate members on a hawk-dove dimension. Once we control for partisan and constituency effects, we find only limited evidence that female legislators are more dovish than their male counterparts are.
Verruciform Xanthoma of the Esophagus: Two Case Reports With Review of the Literature
Authors: Noguchi Hirotsugu , Kitazono Ikumi , Hamada Kazumasa , Tanaka Takako , Tasaki Takashi , Shirahama Hiroshi , Yamamoto Yoshimasa , Tanimoto Akihide
Published: October 2019

Verruciform xanthoma is a rare benign verrucopapillary lesion that develops in the oral mucosa and genital skin. Its development in the esophagus is extremely rare, with only 5 reported cases. We present 2 cases of verruciform xanthoma of the esophagus. Case 1 involved a 91-year-old woman, who had hypertension and chronic gastritis with Helicobacter pylori infection, with a 12-year history of a 10-mm white-yellow elevated lesion on the esophagus, 35 cm from the incisor teeth. Case 2 involved a 70-year-old man with fundic gland polyp, hyperlipidemia, and lung cancer, who had a 10-mm whitish granular/verrucoid lesion on the esophagus, 28 cm from the incisor teeth. Microscopically, these lesions show verrucous and papillomatous epithelial hyperplasia with neutrophilic intraepithelial exocytosis. The histological hallmark is the presence of numerous foamy histiocytes infiltrating the elongated squamous epithelial papillae. Although its etiology is unknown, irritation or trauma caused by radiotherapy has been suggested.
Myxoinflammatory Fibroblastic Sarcoma of Eyeball in an Infant: A Rare Presentation
Authors: Jain Ekta , Kini Lata , Alaggio Rita , Ranganathan Sarangarajan
Published: October 2019

Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare soft tissue neoplasm most commonly occurring in the distal extremities of adult patients. It is a low-grade neoplasm with high rate of local recurrence but low rate of metastasis. We describe a case of MIFS of eyeball in an infant. An enucleation surgery was performed, and on the basis of histopathological and immunohistochemical evaluation, a diagnosis of MIFS was rendered. Till date more than 400 cases of MIFS have been reported with only a single case report of MIFS in an adult in iris. To the best of our knowledge, ours is the first case of MIFS in the eye in a child. Considering its rarity in children and especially in an infant (this seems to be the youngest patient in the literature), close follow-up is essential as the biology of these lesions cannot be predicted.
Upper Urinary Tract Adenocarcinoma Arising in Tubular Adenoma—A Rare Entity: Report of 2 Cases and Review of Literature
Authors: Nambiyar Kaniyappan , Pandey Tushar , Chatterjee Debajyoti , Saikia Uma N. , Mavuduru Ravimohan S.
Published: October 2019

Tubular adenoma of the urinary tract is a recently recognized entity, and there is a paucity of clinicopathological information. We describe 2 rare cases of adenocarcinoma of upper urinary tract arising in the background of tubular adenoma with high-grade dysplasia. The first case was an extremely uncommon combination of multifocal tubular adenomas involving ureter and renal pelvis and adenocarcinoma of kidney in a patient with renal calculi. The second case was of adenocarcinoma of kidney arising from tubular adenoma of renal pelvis in the right moiety of horseshoe kidney. There was no microsatellite instability. These findings indicate, probably, an adenoma-carcinoma pathway is also followed in the urinary tract similar to the gastrointestinal tract. To the best of our knowledge, no such observations are reported in the English literature previously.
Descriptive comparison of hospital formulary decisions with published oncology valuation methods
Authors: Lam Simon W , Siebenaller Caitlin , Earl Marc , Hill Brian T , Kalaycio Matt , Rini Brian , Carraway Hetty E , Leonard Mandy , Sekeres Mikkael A
Published: October 2019

Introduction

As cost of cancer therapy continues to increase, several organizations have developed rubrics to ascertain treatment. No studies have evaluated these methods for hospital formulary decision-making. We applied different value measurement tools to formulary decisions from one hospital system to assess their operational utility.

Methods

We evaluated four value systems: National Comprehensive Cancer Network Evidence Blocks, DrugAbacus drug pricing, European Society for Medical Oncology clinical benefit scale, and the American Society of Clinical Oncology net health benefit. Each value score or cost was assessed against our hospital formulary requests between 2012 and 2016. Formulary requests accepted and rejected were compared with respect to their relative numbers of National Comprehensive Cancer Network blocks, difference between DrugAbacus and actual cost, and European Society for Medical Oncology and American Society of Clinical Oncology scores.

Results

Twenty-two chemotherapy requests were included, with 20 approvals and 2 rejections. No correlation was observed between number of evidence blocks and formulary acceptance (p = 0.13). Most drugs had a higher actual price than the DrugAbacus suggested cost (p = 0.036). No significant differences were observed in European Society for Medical Oncology (p = 0.90) or American Society of Clinical Oncology (p = 0.70) scores between drugs that were accepted or rejected. When evaluating monthly cost per point of American Society of Clinical Oncology score, a numerical difference between groups was observed (median = $369.7 versus $1256.8 per point, p = 0.61).

Conclusions

Existing oncology value assessment systems only variably inform hospital formulary decisions. The American Society of Clinical Oncology net health benefit score deserves further study as a method to systematically quantify the clinical safety and efficacy of formulary medication addition relative to cost.
Fatal neutropenic enterocolitis associated with docetaxel use: A review of cases reported to the United States Food and Drug Administration Adverse Event Reporting System
Authors: Singh Pritpal , Nayernama Afrouz , Christopher Jones S , Amiri Kordestani Laleh , Fedenko Katherine , Prowell Tatiana , Bersoff-Matcha Susan J
Published: October 2019

Docetaxel is a microtubule inhibitor indicated for the treatment of multiple cancers as a single agent or in combination with other antineoplastics. The U.S. Food and Drug Administration (FDA) conducted a postmarketing review of fatal neutropenic enterocolitis cases reported with docetaxel using the FDA Adverse Event Reporting System (FAERS) and literature to determine whether the drug was a potential cause. We searched FAERS and the literature for reports of fatal neutropenic enterocolitis with docetaxel-based treatment reported between 14 May 1996 and 13 March 2017. We characterized the clinical course and severity of neutropenic enterocolitis and utilized the World Health Organization-Uppsala Monitoring Centre rubric to assess drug causality. We identified 41 fatal cases of neutropenic enterocolitis with docetaxel from FAERS and the literature. The median time to onset of neutropenic enterocolitis from last docetaxel dose was seven days (range 2–13 days), and median time to death was nine days (range 3–23 days). The cause of death in 83% (34/41) of patients was neutropenic enterocolitis. We determined the drug-event association as probable in seven cases. Neutropenic enterocolitis with docetaxel monotherapy occurred in six cases; however, in 85% (35/41) of cases, neutropenic enterocolitis occurred when docetaxel was used in combination with other cytotoxic chemotherapy. In some cases, neutropenic enterocolitis occurred despite use of granulocyte colony-stimulating factors. Neutropenic enterocolitis is a severe and potentially fatal complication of docetaxel-based treatment, especially when combined with other antineoplastic treatments known to cause neutropenia. Practitioners should be aware of this safety risk to promptly recognize and manage patients.
Hookah and Electronic Inhalant Device Use and Perceptions Among African American Youth and Young Adults: Are We Asking the Right Questions?
Authors: Sakuma Kari-Lyn K. , Dolcini M. Margaret , Seifert Jessica , Bean Maddison M. , Fagan Pebbles , Wilson Monica , Felicitas-Perkins Jamie Q. , Blanco Lyzette , Trinidad Dennis R.
Published: October 2019

Objectives. Survey items used in surveillance systems to assess the use of emerging products like hookah and electronic inhalant devices (EIDs) may not match definitions used by high-risk populations. This qualitative study explored how African American youth and young adults (YYAs) (1) use hookah and EIDs and (2) identify patterns in the ways they describe and organize these products. Design. Individual in-person interviews were conducted among a sample of continuation high school and vocational school students in southern California. Participation was limited to those who had ever tried at least one tobacco product, self-identified as African American, and were between the ages of 14 and 26 years ( n = 28). We conducted a content analysis to identify patterns in perceptions and use of these products. Results. African American YYAs recognized and described traditional hookah based on physical attributes, but for EIDs, including e-cigarettes, e-hookah, and vape pens, YYAs focused on reasons for using the product. Three primary categories emerged for reasons YYA used specific products: nicotine content and quitting, social facilitation, and use with marijuana. E-cigarettes were identified as quitting aids and as having nicotine but were not considered addictive. The term hookah recalled both the traditional and electronic pen-type products for YYAs. The terms vapes, hookah, wax pens, and others are used in the context of describing product use with marijuana. Conclusions. A better understanding of why African American YYAs use these products is needed to develop better measures for accurate rates of use, uncover differences in use between product types, and to develop effective prevention messaging.
Glomus Tumor of the Kidney in a Child With Tuberous Sclerosis
Authors: Zhao Manli , Yang Min , Gu Weizhong , Chen Xi , Chen Huiyi , Kuick Chik Hong , Chang Kenneth Tou En , Tang Hongfeng
Published: October 2019

Primary glomus tumors of the kidney are rare and have never been reported in children under 16 years of age. Tuberous sclerosis complex (TSC) is an extremely variable genetic condition that can affect virtually any organ in the body. Only a single case of glomus tumor associated with TSC was reported in 1964. In this article, we describe the clinical, radiologic, and pathological features of a primary renal glomus tumor in an 8-year-old girl with TSC. This tumor is large, has a deep location, and has infiltrative margins and numerous mitoses. However, there was no disease progression in a 16-month period of follow-up. To our knowledge, this is the second report of primary renal glomus tumor in childhood, the youngest one in the literature.
Financial Hardship, Motivation to Quit and Post-Quit Spending Plans among Low-Income Smokers Enrolled in a Smoking Cessation Trial
Authors: Rogers Erin , Palacios Jose , Vargas Elizabeth , Wysota Christina , Rosen Marc , Kyanko Kelly , Elbel Brian D. , Sherman Scott
Published: October 2019

Background:

Tobacco spending may exacerbate financial hardship in low-income populations by using funds that could go toward essentials. This study examined post-quit spending plans among low-income smokers and whether financial hardship was positively associated with motivation to quit in the sample.

Methods:

We analyzed data from the baseline survey of a randomized controlled trial testing novel a smoking cessation intervention for low-income smokers in New York City ( N = 410). Linear regression was used to examine the relationship between financial distress, food insecurity, smoking-induced deprivation (SID) and motivation to quit (measured on a 0-10 scale). We performed summative content analyses of open-ended survey questions to identify the most common plans among participants with and without SID for how to use their tobacco money after quitting.

Results:

Participants had an average level of motivation to quit of 7.7 ( SD = 2.5). Motivation to quit was not significantly related to having high financial distress or food insecurity ( P > .05), but participants reporting SID had significantly lower levels of motivation to quit than those without SID ( M = 7.4 versus 7.9, P = .04). Overall, participants expressed an interest in three main types of spending for after they quit: Purchases, Activities, and Savings/Investing, which could be further conceptualized as spending on Oneself or Family, and on Needs or Rewards. The top three spending plans among participants with and without SID were travel, clothing and savings. There were three needs-based spending plans unique to a small number of participants with SID: housing, health care and education.

Conclusions:

Financial distress and food insecurity did not enhance overall motivation to quit, while smokers with SID were less motivated to quit. Most low-income smokers, including those with SID, did not plan to use their tobacco money on household essentials after quitting.
On the Nature of Hydrodynamic Cavitation Process and Its Application for the Removal of Water Pollutants
Authors: Bandala Erick R , Rodriguez-Narvaez Oscar M
Published: October 2019

Cavitation is considered a high energy demanding process for water treatment. For this study, we used a simple experimental setup to generate cavitation at a low pressure (low energy) and test it for hydroxyl radical production using a well-known chemical probe as a hydroxyl radical scavenger. The conditions for generating the cavitation process (eg, pressure, flow velocity, temperature, and other significant variables) were used to degrade model contaminants, an azo dye and an antibiotic. The amount of hydroxyl radicals generated by the system was estimated using N,N-dimethyl-p-nitrosoaniline (pNDA) as hydroxyl radical scavenger. The capability of hydrodynamic cavitation (HC) to degrade contaminants was assessed using Congo red (CR) and sulfamethoxazole (SMX) as model contaminants. Different chemical models were analyzed using UV-visible spectrophotometry (for pNDA and CR) and high-performance liquid chromatography (HPLC) (for SMX) after HC treatment under different process conditions (ie, pressure of 13.7 and 10.3 kPa, and flow rates of 0.14 to 3.6 × 10−4 m3/s). No pNDA bleaching was observed for any of the reaction conditions tested after 60 minutes of treatment, which suggests that there was no hydroxyl radical generation during the process. However, 50% degradation of CR and 25% degradation of SMX were observed under the same process conditions, comparable with previously reported results. These results suggest that the process is most likely thermally based rather than radically based, and therefore, it can degrade organic pollutants even if no hydroxyl radicals are produced. Hydrodynamic cavitation, either alone or coupled with other advanced water technologies, has been identified as a promising technology for removing organic contaminants entering the water cycle; however, more research is still needed to determine the specific mechanisms involved in the process and the optimal operation conditions for the system.
A Middle Cuneiform Stress Fracture in an Adolescent Athlete: A Case Report and Literature Review
Authors: Krebs Paul , Borchers James
Published: October 2019

A 13-year-old female soccer and basketball athlete presented with pain in the arch of her foot. Magnetic resonance imaging confirmed the diagnosis of a middle cuneiform stress fracture. The patient’s stress fracture healed nonoperatively over a 10-week period complicated by nonadherence to a fracture boot, after which she was progressed back to full activity. Knowledge of these fractures and their treatment are important for sports medicine physicians, as they can often be overlooked, given their infrequent occurrence. There have been 8 previous case reports and 1 case series on cuneiform stress fractures, and these are summarized with this case report.
Building bridges between psychoanalysis and music
Authors: Gaitanidis Anastasios
Published: October 2019

In this article, I begin by presenting how a Greek song erupted within the flow of my everyday existence and allowed me to reconnect with past trauma, grief and psychic pain. Operating in a register which is different from that of symbolic language, and yet always already within it, music enables productive encounters with trauma and loss in everyday life. I then continue exploring the connections between music and language by employing Kristeva’s notions of ‘chora’ and the ‘semiotic’, which place the ‘musicality’ of language, its rhythm and tonality, and pitch and timbre at the centre of the analyst’s attention. I finish by referring to the work of Ogden who argues that both poetry/music and certain analytic sessions seem to generate powerful resonances and cacophonies of sound and meaning.
Impact of gasoline direct injection fuel films on exhaust soot production in a model experiment
Authors: Roque Anthony , Foucher Fabrice , Lamiel Quentin , Imoehl Bill , Lamarque Nicolas , Helie Jerome
Published: October 2019

The fuel films that can be generated during the injection process in gasoline direct injection engines are the most important factor in carbon particle mass and number. They also have an influence on combustion chamber and injector tip deposits. A model experiment was set up to study a liquid film, its evaporation, and combustion with soot generation on a metal plate in realistic engine conditions. The experiment was conducted in a dedicated constant volume vessel. A liquid fuel injection system (with injection pressures up to 100 bar) directs the spray onto a plate with a controlled temperature in the range of 80 °C–200 °C. The resulting liquid film and vaporization process were studied when subjected to interaction with a laminar spherical flame. A blend of four components was used as a gasoline surrogate. The liquid film spreading, thickness, and evaporation rates were initially measured in ambient conditions. Mie scattering and schlieren measurements in the chamber conditions returned a qualitative correlation of the vaporized area with the surface temperature. Fluorescence of the light and heavy fuel components was used to quantify the influence of the vaporization process on soot production. Simultaneous measurements of natural luminosity and KL factor were analyzed to understand the process of soot production. The results showed a critical wall temperature of 120 °C at which the maximum quantity of soot is generated, which can be due to the quantity and composition of fuel film in interaction with the entrainment flows generated during combustion.
Structural investigation of perfluorocarboxylic acid derivatives formed in the reaction with N,N-dimethylformamide dialkylacetals
Authors: Stróżyńska Monika , H. Gross Jürgen , Schuhen Katrin
Published: October 2019

A structural investigation of perfluorocarboxylic acid derivatives formed in the reaction with N,N-dimethylformamide dialkylacetals employing several techniques of mass spectrometry (MS) is described. Two derivatizing reagents, dimethylformamide dimethyl acetal (DMF-DMA) and dimethylformamide diethylacetal (DMF-DEA) were used. In contrast to carboxylic acids, perfluorocarboxylic acids are not able to form alkyl esters as the main product in this reaction. We found that perfluorooctanoic acid (PFOA) forms a salt with N,N-dimethylformamide dialkylacetals. This salt undergoes a further reaction inside the injection block of a gas chromatograph (GC) by loss of CO2 and then forms 1,1-perfluorooctane-(N,N,N,N-tetramethyl)-diamine. The GC-MS experiments using both electron ionization (EI) and positive-ion chemical ionization (PCI) revealed that the same reaction products are formed with either derivatizing reagent. Subjecting the perfluorocarboxylic acid derivative to electrospray ionization (ESI) and direct analysis in real time (DART), both positive- and negative-ion modes indicated that cluster ions are formed. In the positive-ion mode, this cluster ion consists of two iminium cations and one PFOA anion, while in the negative-ion mode, it comprises two PFOA anions and one cation. The salt structure was further confirmed by liquid injection field desorption/ionization (LIFDI) as well as infrared (IR) spectroscopy. We propose a simple mechanism of N,N,N′,N′-tetramethylformamidinium cation formation. The structure elucidation is supported by specific fragment ions as obtained by GC-EI-MS and GC-PCI-MS analyses.
Relationship between adherence to secondary prevention and health literacy, self-efficacy and disease knowledge among patients with coronary artery disease in China
Authors: Lu Minmin , Xia Haiou , Ma Jianying , Lin Ying , Zhang Xian , Shen Yunzhi , Hravnak Marilyn
Published: October 2019

Background:

Adherence to secondary prevention is an indispensable part of the management of patients with coronary artery disease. Finding patient factors affecting their adherence behaviours is important for improving the treatment effect and limiting further disease progression.

Aims:

To examine the association between health literacy, self-efficacy, disease knowledge and adherence to secondary coronary artery disease prevention in patients in China.

Methods:

In this cross-sectional study, 598 patients with coronary artery disease were enrolled in two tertiary hospitals in China during a hospitalisation for receiving percutaneous coronary intervention. Patient-reported data were collected on demographics, health literacy, self-efficacy, disease knowledge and adherence to secondary coronary artery disease prevention (medication-taking and heart-healthy lifestyle (exercise, reducing/eliminating alcohol intake and smoking, low salt and fat diet, stress reduction)). Chi-squared tests and regression analyses were performed.

Results:

The proportions of recalled self-report of adherence to medication-taking and a heart-healthy lifestyle immediately prior to the coronary artery disease hospitalisation were 84.7% and 53.2%, respectively. In logistic regression, health literacy, self-efficacy and disease knowledge was significantly associated with non-adherence to secondary coronary artery disease prevention. Limited health literacy demonstrated a 1.61-fold odds for non-adherence to a heart-healthy lifestyle. Each score increase of self-efficacy and disease knowledge had 0.98-fold odds and 1.05-fold odds of non-adherence to a heart-healthy lifestyle.

Conclusions:

Adherence to medication-taking was relatively good in Chinese patients prior to coronary artery disease hospitalisation, but adherence to heart-healthy lifestyle behaviours should be improved. Health literacy, self-efficacy and disease knowledge should be taken into account when intervening to improve secondary coronary artery disease prevention.
Experimental and computational investigation of energy ball wind turbine aerodynamic performance
Authors: Elshazly Engy , Eltayeb Nabil , Abdel Fatah Amr A , El-Sayed Tamer Ahmed
Published: October 2019

Small-scale wind turbines with innovative design are introduced for small applications, providing clean renewable energy to rural homes, street lighting, and hybrid systems. Energy ball wind turbine, known as Venturi wind turbine, has untraditional blades’ shape and special aerodynamic behavior that creates a venturi effect on the air stream passing through its aspherical shape. This article represents an integration of computational fluid dynamics and wind tunnel experimentation to study the aerodynamic performance of a manufactured model of energy ball wind turbine. Physical models with different twist angles were fabricated and tested in a small wind test section. In these experiments, dynamic torque, angular velocity, and coefficient of performance values were measured at different speeds. The experimental power coefficient results were discussed showing the best-tested twist angle. Fluid flow simulation has been developed in ANSYS FLUENT software. The findings of these numerical simulations have provided pressure contour, velocity contour, and torque values which help to study the solidity effect on turbine’s power coefficient. Nevertheless, the velocity contours provided from the computational analysis ensure the Venturi effect of the energy ball wind turbine design.
Comparison of volar locking plates with external fixation and K-wires in arthroscopically assisted intra-articular distal radial fracture fixation
Authors: Krustins Uldis , Krustins Janis , Bringina Diana , Laurane Kristine , Jumtins Andris
Published: October 2019

This article presents the results of a prospective cohort study that included 63 patients with intra-articular (AO Type C) distal radial fractures who were treated using an arthroscopically assisted approach with either volar locking plates or external fixator and K-wires. Postoperative analysis was carried out using X-ray assessment, clinical data, Patient-Rated Wrist Evaluation score, Gartland and Werley score, Modern Activity Subjective Survey of 2007 score, range of motion, grip, pinch and tripod pinch assessment at 1, 3, 6 and 12 months postoperatively. Despite the statistically significant differences found in a number of parameters during the period of observation, there were no clinically relevant differences determined between the two methods. There was a greater number of complications in the external fixator and K-wire treated patients.

Level of evidence: II
High immunoglobulin E level is associated with increased readmission in children with bronchopneumonia
Authors: You Cun , Ran Guo , Wu Xiao , Wang Yu , Tian Hua , Fan Jiabao , Yao Zezhong , Wang Fei
Published: October 2019

Background:

Increased immunoglobulin E (IgE) is associated with lower respiratory tract infections. The study aimed to evaluate the association between IgE and the rate of bronchopneumonia-related readmission within 12 months in children.

Methods:

A total of 1099 children aged over 1 year with bronchopneumonia, from 1 January 2015 to 31 December 2016, were enrolled. Unplanned readmissions within 12 months after discharge were observed. Multivariate regression analysis was used to identify independent risk factors for rehospitalization.

Results:

The rate of rehospitalization was 11.4% (125/1099). Compared to the nonreadmission children, IgE levels, the proportion of children with asthma and hospitalization duration were significantly higher in the readmission children ( p < 0.05). Compared to the children with normal IgE (≤ 165 IU/ml) levels, the risk of rehospitalization was significantly higher in children with abnormal IgE [odds ratio (OR) 1.781, 95% confidence interval (CI) 1.209–2.624, p = 0.004]. Children with IgE level more than three times the upper limit had even higher risks of readmission (OR 2.037, 95%CI 1.172–3.540, p = 0.012). Meanwhile, the risk of readmission in children with abnormal IgE combined with or without bronchial asthma was significantly higher (OR 2.548 and 1.918, 95% CI 1.490–4.358 and 1.218–3.020, p = 0.001 and 0.005, respectively).

Conclusions:

Children aged over 1 year with bronchopneumonia who had higher IgE levels are at increased risk for rehospitalization within the first 12 months of the index hospitalization and IgE level may be used as a predictor of rehospitalization in children with bronchopneumonia.
A case report of resolution of acrokeratosis paraneoplastica (Bazex syndrome) post resection of non-small-cell lung carcinoma
Authors: Mititelu Roxana , Powell Mathieu
Published: October 2019

Acrokeratosis paraneoplastica (Bazex syndrome) is a paraneoplastic syndrome frequently associated with squamous cell carcinoma of the aerodigestive tract. We present a case of acrokeratosis paraneoplastica associated with non-small-cell lung carcinoma, which completely resolved once the carcinoma was resected.
#WeTheNorth: Examining an Online Brand Community Through a Professional Sport Organization’s Hashtag Marketing Campaign
Authors: Naraine Michael L. , Pegoraro Ann , Wear Henry
Published: October 2019

The use of hashtags has become an important strategy in digital marketing, anchoring online conversations. The conversations stemming from the use of hashtags can comprise both meaningful dialogue between users and brands, and one-off spontaneous sentiments. As such, hashtags can aid in the formation of a team’s online brand community and can be useful to understand and target key segments of users. In this research, an examination of the Toronto Raptors’ #WeTheNorth campaign in the National Basketball Association was engendered to highlight (a) the types of communication networks formed through the use of the hashtag and (b) the types of segments that are derived from the hashtag (as well as their characteristics). The findings present insights that provide pertinent antecedents for future marketing activities for sport brands as they seek to develop communities of identified fans.
Hear It Their Way: Micro-Invalidation and the Burden of “Articulateness”
Authors: Hudson Monika L. , Hunter Keith O.
Published: October 2019

Given the unconscious nature of many micro-invalidations, conversations about them easily devolve into cycles of accusation, defensiveness, and recrimination. To better understand the specific effects of micro-invalidations, this interactive exercise emphasizes listening, hearing, and empathizing with use of the statement, “You are so articulate.” By stressing and analyzing different segments of this frequently used sentence, learners are presented with an opportunity to consider both sides of oral messaging—the intent of the sender as well as the receipt and interpretation of the receiver. Both intended and unintended consequences are analyzed, opening deeper discussions about the origins and implications of our reactions to other people and their remarks.
Non-path dependent urban growth potential mapping using a data-driven evidential belief function
Authors: Arasteh Reza , Ali Abbaspour Rahim , Salmanmahiny Abdolrassoul
Published: October 2019

Improper urbanization and its environmental impacts have imposed many problems to humanity. Recently, numerous studies have been conducted using different methods to understand and manage spatial and temporal changes in urbanization. In this study, the capability of the data-driven evidential belief function model as a non-path dependent urban growth potential mapping method was evaluated. Using this approach, the conventional trend-based urban growth prediction procedure is transformed into a data integration task through which the potential locations for urban sprawl in response to multiple environmental and anthropogenic variables could be determined. Therefore, true knowledge about urban growth conditioning factors and their quantitative relationships with built-up areas can be obtained. The multivariate-based logistic regression model as a well-known urban growth modelling method was employed to check the efficiency and validity of the proposed evidential belief function model. Furthermore, a hybrid approach based on the logistic regression model results coupled with the data-driven evidential belief function model was developed. The validation results using the relative operating characteristic method indicated that the evidential belief function, logistic regression, and the hybrid methods’ accuracy were 91.81, 84.72, and 92.34%, respectively. Therefore, it can be concluded that while the proposed evidential belief function and hybrid methods for non-path dependent urban growth potential mapping yielded approximately equal results, both of them outperformed the logistic regression model which is an indication of their reliability and accuracy. The proposed evidential belief function and hybrid methods are best suited for integration in different environmental and socio-economic scenarios enhancing the models for urban allocation tasks. In this way, local communities and policy-makers can make smarter decisions.
The history of Nôm: A periodization
Authors: Du’o’ng Trần Trọng
Published: October 2019

This article offers a periodization of Nôm history. The criteria established in this study include those aspects of grammatology, linguistics (historical phonetics), textology, the interaction between languages and writing systems and the historical-social context. We propose that the history of Nôm can be divided into the following seven main periods: (a) Proto Nôm (8th–9th centuries); (b) Archaic Nôm (10th–12th centuries); (c) Ancient Nôm (13th–15th centuries); (d) Ancient-Middle Nôm (16th–17th centuries); (e) Middle Nôm (18th century–1884); (f) Modern Nôm (1884–1945); (g) Contemporary Nôm (1945–present). As a medium of transcribing the Vietnamese language, Nôm script has a history of nearly 12 centuries in parallel with the history of the Vietnamese language. The tendencies of grammatological transformation go in the same direction with the transformational tendencies of the Vietnamese language as well as of Vietnamese socio-cultural history.
Overexpression of the TGF-Beta Modulator .Bambi Promotes Hematopoetic Stem Cell Proliferation.
Authors: Mao Rui , Sirin Olga , Goodell Margaret
Published: October 2019

Abstract 1446

Poster Board I-469

Hematopoietic stem cells (HSC) normally reside in a quiescent state in the bone marrow. During times of stress, HSCs are activated to begin differentiation and self-renewal, replenishing the supply of myeloid and lymphoid cells present in the blood. The mechanisms regulating this rapid activation have not been fully elucidated. We previously identified the TGF-beta modulator Bambi (BMP and activin membrane-bound inhibitor) to be upregulated four-fold in HSCs compared to differentiated cells. Bambi codes for a transmembrane pseudoreceptor that inhibits TGF-beta receptor activation. Since TGF-beta signaling has been established to be important for induction of HSC quiescence as well as cell-cycle inhibition in long-term progenitors, we hypothesize that Bambi may play an important role in the regulation of HSCs. Using a retroviral vector, we overexpressed Bambi in bone marrow cells. Overexpression of Bambi resulted in increased colony-formation in vitro when compared to control cells. Furthermore, transduced cells expressed higher levels of the cell-cycle marker Ki-67, indicating a greater proportion of cells in active stages of the cell cycle. To verify the results of these assays in vivo, bone marrow overexpressing Bambi was transplanted into lethally irradiated recipient mice. Bambi-overexpressing cells demonstrated a higher level of engraftment in all lineages than control cells at several time points, which confirms the previous in vitro data suggesting greater cell cycle activity. Moreover, we identified the pathway through which Bambi acts by monitoring the levels of phosphorylated Smad2 (pSmad2), a downstream target of TGF-beta. Overexpression of Bambi resulted in a distinctly lower level of pSmad2, which explains the cell-cycle effects seen in vivo and in vitro. These studies show that Bambi functions to promote HSC proliferation and a probable mode of action in HSCs is through decreased pSmad2 levels from inhibition of the TGF-beta pathway. Bambi has been shown to be upregulated in certain leukemias, and a more complete understanding of the mechanism through which Bambi acts will provide better opportunities for therapeutic innovation.

This research was graciously funded by an NIH grant and the ASH Trainee Research Award.

Disclosures

No relevant conflicts of interest to declare.
Simultaneous Targeting of SHH/ p53 Pathways in Large B Cell Lymphomas.
Authors: Chari Nikhil S , Teo Albert E.K. , Medeiros L. Jeffrey , McDonnell Timothy J.
Published: October 2019

Abstract 1730

Poster Board I-756

The sonic hedgehog (SHH) pathway, associated with proliferative stem cell niches of many organs, is frequently deregulated in diverse cancers. We have previously shown that the SHH pathway augments the survival of tumor cells by inducing antiapoptotic molecules including bcl-2 and provides resistance to a number of conventional cancer therapies. Aberrant activation of the SHH pathway has been associated with activation and maintenance of lymphoid malignancies. Additionally, our recent data indicates that p63, a p53 family member and an important marker of stem cells has multiple interacting nodes with the SHH pathway. Based on these observations, we hypothesized i) that there is crosstalk between the SHH and p53/p63 networks in cells and, ii) inhibition of the SHH pathway with simultaneous activation of the p53 pathway would result in increased cell death in cancer cell lines of lymphoid origin. Using SDS-PAGE followed by immunoblotting and RT-PCR we surveyed a panel of 18 leukemia/lymphoma cell lines for components of the SHH pathway and the p53/p63/p73 network. Robust SHH pathway expression was observed in 15 of the 18 cell lines examined. Interestingly, in p53 deficient cell lines there was an increase in p63/p73 expression as compared to cell lines with wild type (WT) p53. A set of the previously analyzed diffuse large B- cell lymphoma (DLBCL) cell lines were selected and were representative of both p53 deficient and WT cell lines and also the activated B-like DLBCL (ABC) and germinal center B-like DLBCL (GCB) subgroups. These cells were treated with cyclopamine, an inhibitor of the SHH pathway and/or nutlin, an HDM2 antagonist. Cell viability (MTS assay) was measured using both compounds at various drug concentrations and time points. In addition we also investigated the effects of the drugs individually and in combination on components of the p53/p63 and SHH axes and their targets. Our findings suggest that treatment of p53 (WT) cell lines with a combination of nutlin and cyclopamine results in reduced cell survival than treatment with either drug alone and at lower drug concentrations and that the p53 status of the cell line may be more important in determining therapeutic response to the selected compounds. In addition the p53/p63 pathway may have a novel role in regulation of specific components of the SHH pathway in cells of lymphoid origin. In conclusion, these observations provide proof of concept that a combinatorial therapeutic approach, targeting both the p53 and SHH axes would provide a more robust and favorable response in large B cell lymphomas.

Acknowledgments

This work was supported in part by the The Mehta Family Foundation

Disclosures

No relevant conflicts of interest to declare.
CHOP-R + Bortezomib as Initial Therapy for Mantle Cell Lymphoma (MCL).
Authors: Ruan Jia , Martin Peter , Furman Richard R , Vose Julie M. , LaCasce Ann , Cheung Ying-Kuen K. , O'Loughlin Jennifer , Elstrom Rebecca , Niesvizky Ruben , Chadburn Amy , Ely Scott , Cesarman Ethel , Coleman Morton , Leonard John P.
Published: October 2019

Abstract 2682

Poster Board II-658

BACKGROUND:

Bortezomib is a proteasome inhibitor with single agent activity in mantle cell lymphoma. Preclinical studies have demonstrated that addition of bortezomib to chemoimmunotherapy can enhance antitumor effects. We report findings from a phase I/II trial of dose-escalated bortezomib + standard CHOP-rituximab (R) in previously untreated MCL patients.

METHODS:

From 6/2004 to 10/2007, 36 patients with previously untreated MCL received standard CHOP-21 with rituximab (375 mg/m2 per cycle) plus bortezomib at 1.0 mg/m2 (n=4) or 1.3 mg/m2 (n=32) on days 1 and 4 of each cycle for a total of 6 cycles. Study endpoints included safety and efficacy assessment.

RESULTS:

At study entry, median age (n=36) was 66 years (range 45–80), and M:F ratio was 5:1. Thirty-four subjects (94%) had stage III/IV disease, and 18 (50%) had elevated serum lactate dehydrogenase (LDH). Patients generally had unfavorable baseline international prognostic index (IPI) scores (42% with IPI of 2, and 47% with IPI of 3–5), as well as MIPI scores (28% with intermediate risk and 39% with high risk). Treatment was generally well tolerated. Peripheral neuropathy (sometimes reversible) occurred in 20 subjects (56%) with 16 grade 1, 3 grade 2, and 1 grade 3. Grade 3/4 cytopenias included anemia (11%), neutropenia (23%) and thrombocytopenia (14%). At a median followup of 30 months (range 8–61 months), 32 patients are evaluable for efficacy. For all patients (n=36), the intent-to-treat (ITT) overall response rate (ORR) is 81% with 64% CR/CRu. For evaluable patients (n=32), the ORR is 91%, and CR/CRu 72%. The median progression free survival for all patients (n=36) is 21 months (95% CI 17-29) by Kaplan-Meier estimate, and 2 year overall survival is 86% (95% CI 69–94%). Currently eight patients remain in ongoing response (range 15–39 months). In a univariate Cox regression analysis, IPI correlated with PFS (HR 1.85, p=0.023), while MIPI correlated with both PFS (HR 1.81, p=0.027) and OS (HR 2.6, p=0.033).

CONCLUSIONS:

Bortezomib in conjunction with R-CHOP-21 can be safely administered in an outpatient regimen to previously untreated MCL patients, including the elderly. Further evaluation of combinations of bortezomib with R-CHOP is warranted.

Disclosures:

Vose: Genentech, Inc.: Consultancy, Research Funding. Coleman:Millenium: Speakers Bureau. Leonard:Millenium: Consultancy, Honoraria; Johnson & Johnson: Consultancy, Honoraria; Genentech: Consultancy, Honoraria; Biogen Idec: Consultancy, Honoraria.
Care Practices in Gaucher Disease: Results of a French Study.
Authors: Nadia Belmatoug , Guffon Nathalie , Stirnemann Jérôme , Serratrice Christine , Robert Alain , Rose Christian , Bruno Padrazzi , Kaminsky Pierre
Published: October 2019

Abstract 4441

Introduction

Gaucher Disease (GD) management is well defined but little is known about the management of patients in routine practice. To describe it, this multicentre retrospective survey was proposed to all French Hospital Departments in whom Gaucher patients are monitored. Demographic and clinical data were collected, and therapeutic regimens were detailed.

Results

In 2008, 118 patients were enrolled in 54 centres, including 111 type 1 (GD1) and 7 type 3 (GD3). 90% of patients were adults at inclusion. At time of diagnosis 40% of GPS patients were less than 16 years. Glucocerebrosidase activity assay and bone marrow aspiration were part of the diagnosis in 80% and 51% of patients, respectively. A family survey has been performed in all children and overall in 85 % of patients, with positive results in 44% of cases. 54% of patients are managed by the physician who diagnosed the GD and the mean annual number of visits at hospital is 10 and 4 for children and adults, respectively. In patients diagnosed after the age of 16 years, 20.7% were splenectomised at time of inclusion. On average, hemogram and chitotriosidase are assessed twice a year, as bone mineral density and skeletal MRI are performed every 2 years. Ninety-six patients are treated with imiglucerase, 3 patients with miglustat and 2 patients with a combination of both. Adult patients were treated on average for 87.6 months versus 53 months for children. The mean Imiglucerase dose is 54 U/kg by infusion for GD1 with no significant difference regarding infusions frequencies, and 96 U/kg for GD3 and The treatment is infused every two weeks in 74% of the patients, and every 3 weeks in 18% of them, using a gravity infusion in 57 % of the cases. Only 7.8% of the GPS population is infused using a central venous access with similar rates in adults and children. Infusions are administered at hospital in 60% of cases and at patient's home in 40% of cases. A central venous access is used in 11% of patients who are treated at home. Infusion time is less than 2 hours in 55% of patients and is slightly longer at home compared to hospital. Observance is good or excellent in more than 95% of cases.

Conclusion

This is the first large national survey about Care Practices in GD patients. The clinical and biological follow-up is globally in line with French Guidelines. Treatment with imiglucerase is administered on average at the recommended dose and frequency, but with an infusion time often longer than that recommended. Patients should be more frequently treated at home, and thus quality of life studies and encouragement of home infusions organisation should be performed in France.

Disclosures:

Off Label Use: Cerezyme (imiglucerase) : enzymatic replacement therapy for Gaucher disease patients. The aim of imiglucerase is to replace glucocerebrosidase deficiency; The dose of treatment initiation is 60u/kg/2 weeks.. Bruno:Genzyme: Employment.