bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of bone marrow mesenchymal stem cells on cisplatin induced cytotoxicity in parotid gland of rats (Histological and Ultrastructural studies)
Authors: Abdelaziz Ahmed , sherif Hany , mawla Abd Elnasser Abd El
Published: November 2023

Objective: the current study was implemented to assess the therapeutic efficacy of bone marrow mesenchymal stem cells on parotid glands following cytotoxicity induced by cisplatin administration in rats.
Materials and Methods: The study employed a sample of 36 adult male Sprague-Dawley rats. The samples were categorized into two groups. Group I: The control group (6 rats) received 0.5ml phosphate-buffered saline. Group II: The experimental group was divided into two subgroups; subgroup (A), referred to as the cisplatin group, (15 rats) was administered a solitary intraperitoneal injection of the cisplatin medication at a dosage of 10 mg/kg. Subgroup (B) BMMSc group (15 rats) was administered the same dose of cisplatin as subgroup A. On day three following cisplatin administration, 5x105 BMMSCs suspended in 0.5 ml of PBS were injected intraparotid. After cisplatin injection and BMMSc administration rats were sacrificed according to different time intervals (7 and 21 days) for histological and ultrastructural analysis.
Results: stem cell treated group exhibited superior histological and ultrastructural characteristics.
Conclusion: This investigation proved that BMMSCs can improve the histological and ultrastructural changes of parotid gland induced by cisplatin administration.
Privatization Neutrality Theorem in the Presence of Vertically Related Industries
Authors: Wu Tsaur Chin , Chang Hsiu-Wei
Published: November 2023

This paper considers a model wherein public and private firms purchase inputs from a foreign firm to produce a homogenous good and compete in quantity. Using this model, we examine the optimal subsidy for the public and private firms and the optimal degree of privatization. In particular, the privatization neutrality theorem (PNT), which means that the optimal subsidy achieves the first-best allocation and is independent from the degree of privatization, is explored. There are three main results. First, when the foreign firm competitively behaves, the PNT holds. Second, when the foreign firm is a monopolist and applies the uniform pricing, the PNT does not hold and the optimal policy is full nationalization. Finally, when the foreign firm adopts the discriminatory pricing, the PNT does not hold and the optimal policy is partial privatization.
Mesothelin promotes brain metastasis of non-small cell lung cancer by activating MET
Authors: Xia shengkai , Duan Wenzhe , Xu Mingxin , Li Mengqi , Tang Mengyi , Wei Song , Lin Manqing , Li Encheng , Liu Wenwen , Wang Qi
Published: November 2023

Brain metastasis (BM) is common among cases of advanced non-small cell lung cancer (NSCLC) and is the leading cause of death for these patients. Mesothelin (MSLN), a tumor-associated antigen expressed in many solid tumors, has been reported to be involved in the progression of multiple tumors. However, its potential involvement in BM of NSCLC and the underlying mechanism remain unknown. In this study, we found that MSLN expression was significantly elevated in both serum and tumor tissue samples from NSCLC patients with BM and correlated with a poor clinical prognosis. Our in vitro and ex vivo experiments demonstrated that MSLN significantly enhanced the brain metastatic abilities of NSCLC cells, especially blood–brain barrier (BBB) extravasation. Mechanistically, we found that MSLN facilitated the expression and activation of MET through the c-Jun N-terminal kinase (JNK) signaling pathway, which allowed tumor cells to disrupt tight junctions and the integrity of the BBB and thereby penetrate the barrier. Intriguingly, our in vivo experiments indicated that drugs targeting MSLN (anetumab) and MET (crizotinib) effectively blocked the development of BM and prolonged the survival of mice, with anetumab showing a superior therapeutic effect compared with crizotinib. In conclusion, our results demonstrate that MSLN plays a critical role in BM of NSCLC by modulating the JNK/MET signaling network and thus, provides a potential novel therapeutic target for preventing BM in NSCLC patients.
A Method for Quantitative Analysis of Long-distance Cellular Communication in 3D Time-lapse in vivo Living Embryos
Authors: LI Zelin , ZHAO Zhongying , YAN Hong
Published: November 2023

Background: Embryogenesis is a precise process with cell growth patterns, where the embryonic development is related to the cell morphological features. The cell morphology and cell-cell contact are crucial for biophysically quantitative analysis of in vivo animals. The studies of cell-cell contact and communication are increasing to understand the influence mechanisms in the growing embryonic systems. Morphological features are the significant ways to know the details of inner cellular development during embryogenesis. Studies of cell-cell interactions do not adequately take account of the impact of the cell-cell contact and communication.
Methods: An cellular features embedding method is proposed for cellular contact study, where the Alpha shape helps the method build accurate 3D cell-cell contact graphs for long-distance cell-cell communication. Graph wavelet transform (GWF) embedding can systematically characterize the morphological features of the contact cells of a cell. The embedded morphological features, like cell size ratio, with higher precision, are applied in the power law relationship between the cell size ratio and the cell cycle duration in C. elegans.
Conclusions: The proposed method enables the analysis of accurate 3D cellular features by integrating information of cell neighborhoods, showing that long-distance cellular communication exists during early embryogenesis. With long-distance communication information extracted by graph wavelet, asymmetries between the enhanced morphological features explains cell lineage patterns well.
Green IT: environmentally friendly methods for information technology in the future
Authors: Yadav Alka , Manjhvar Amit Kumar , Parte Smita
Published: November 2023

Information technology's (IT) rapid expansion has raised previously unheard-of environmental problems, which have sparked a paradigm shift towards sustainable practises known as "Green IT." This study investigates the intricate topic of green information technology (Green IT) with the goal of reducing the environmental effect of technology-driven activities. This study explores many approaches that include ecologically friendly software development methods, energy-efficient hardware, and conscientious e-waste management, with an emphasis on the critical relationship between technological innovation and ecological conservation. It offers a thorough summary of the effects of Green IT on organisational sustainability and its implications for global ecosystems by combining case studies, industry best practises, and current trends. This study also examines the barriers to broader adoption and offers practical recommendations for promoting an IT environment that is more ecologically conscientious. Looking ahead, this study emphasises how Green IT may change the information technology industry and is a crucial element in creating a sustainable future for the industry.
Single-cell RNA-seq integration unveils liver vulnerability to tumor metastases: insights from myeloid cell characterization in pancreatic cancer liver metastatic
Authors: Ainiwaer Aizier , Qian Zhenwei , Dong Zheng , Lu Ying , Wang Jianxun , Yu Lingxiang , Zhao Qi , Lu Yinying
Published: November 2023

Background: The liver is the predominant metastatic site for diverse cancers, including pancreatic and colorectal cancers, etc. Liver metastasis increases cancer-related mortality, yet we have limited knowledge of the metastatic microenvironment to effectively target this process. Therefore, it is critical to understand the mechanisms underlying how the hepatic host tissues and immune cells differentially influence metastases in different cancers.
Methods: We integrated two single-cell RNA-seq (scRNA-seq) datasets of pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC), including samples of primary pancreatic cancer (PP), primary colorectal cancer (PC), peripheral blood mono-nuclear cells (PBMC), adjacent normal pancreatic tissue (NPT), liver tissues from pancreatic cancer liver metastasis (P-LM), and colorectal cancer liver metastasis (C-LM). Cell clusters were manually annotated by known markers to demonstrate the cellular compositions of each group. We comparatively analyzed the cell-cell communications and enriched signaling pathways of P-LM and C-LM. The development trajectories of cell clusters were analyzed using Slingshot cell lineage inference algorithm.
Results: In this study, we performed comparative analysis on cellular compositions between P-LM and C-LM and found myeloid cells exhibited a distinct enrichment profile between the two cancer metastases. Fifteen subclusters of 21,777 myeloid cells were recognized, including cell types such as macrophages, monocytes, and dendritic cells (DCs). We found Mph_SPP1, a subset of macrophages associated with angiogenesis and tumor invasion, was more prevalent in the P-LM group, indicating its specific pro-metastasis role in pancreatic cancers. Analysis of the developmental trajectory implied that Mph_SPP1 may progressively be furnished with increased expression of genes regulating endothelium as it evolved from monocytes. Cell-cell communications analysis revealed that Mph_SPP1 potentially interacts with endothelial cells in P-LM via FN1/SPP1-ITGAV/ITGB1, implying this macrophage subset may construct an immunosuppressive liver microenvironment for pancreatic cancer by regulating endothelial cells. We also found that Mph_SPP1 has a prognostic value in pancreatic adenocarcinoma that is not present in colon adenocarcinoma or rectum adenocarcinoma.
Conclusions: We hypothesized that Mph_SPP1 actively creates a fertile environment for tumors when pancreatic cancer metastasizes to the liver and promote cancer invasion in a pro-angiogenetic pattern. Therefore, Mph_SPP1 has the potential to be a target of immunotherapy for liver metastasis in pancreatic cancer. These findings provide a foundation for understanding the immune characteristics of hepatic tumor microenvironment (TME) in patients with liver metastases and new ideas for the precise therapy of liver metastases.
Colloidal aziridinium lead bromide quantum dots
Authors: Bodnarchuk Maryna I. , Feld Leon G. , Zhu Chenglian , Boehme Simon C. , Bertolotti Federica , Avaro Jonathan , Aebli Marcel , Mir Showkat Hassan , Masciocchi Norberto , Erni Rolf , Chakraborty Sudip , Guagliardi Antonietta , Rainò Gabriele , Kovalenko Maksym V.
Published: November 2023

The compositional engineering of lead-halide perovskite nanocrystals (NCs) via the A-site cation represents a lever to fine-tune their structural and electronic properties. However, the presently available chemical space remains minimal since, thus far, only three A-site cations have been reported to favor the formation of stable lead-halide perovskite NCs, i.e., Cs+, formamidinium (FA), and methylammonium (MA). Inspired by recent reports on bulk single crystals with aziridinium (AZ) as the A-site cation, we present a facile colloidal synthesis of AZPbBr3 NCs with narrow size distribution and size tunability down to 4 nm, producing quantum dots (QDs) in the regime of strong quantum confinement. NMR and Raman spectroscopies confirm the stabilization of the AZ cations in the locally distorted cubic structure. AZPbBr3 QDs exhibit bright photoluminescence with quantum efficiencies of up to 80%. Stabilized with cationic and zwitterionic capping ligands, single AZPbBr3 QDs exhibit stable single-photon emission – another essential attribute of QDs. In particular, didodecyldimethylammonium bromide and 2-octyldodecyl-phosphoethanolamine ligands afford AZPbBr3 QDs with high spectral stability at both room and cryogenic temperatures, reduced blinking with a characteristic ON fraction larger than 85%, and high single-photon purity (g(2)(0)=0.1), all comparable to the best-reported values for MAPbBr3 and FAPbBr3 QDs of the same size.
Was meinst du eigentlich, wenn du von ‹Feedback› sprichst?
Authors: Brück-Hübner Annika , Schluer Jennifer
Published: November 2023

Ein Blick in die (medien-)pädagogische Forschungsliteratur verdeutlicht, wie vielfältig zentrale Begriffe wie z. B. der des ‹Feedbacks› verstanden werden. Grund hierfür sind nicht nur divergierende theoretische Annahmen und forschungsmethodische Herangehensweisen, sondern auch unterschiedliche lehr-/lernmethodische Auffassungen sowie die damit verbundene konkrete didaktische Umsetzung in der Lehre. Der Pluralität didaktischer Szenarien wurde in bisherigen Feedback-Reviews jedoch kaum Aufmerksamkeit geschenkt, obwohl didaktische Designs Auswirkungen auf den Lernerfolg und somit auch die Studienergebnisse haben können. Ursache hierfür ist eine oftmals unzureichende Beschreibung der Feedbackszenarien in den Primärstudien, welche wiederum die Herausarbeitung von Schlussfolgerungen und Effektstärken in Meta-Analysen erschwert. In diesem Beitrag wird ein qualitativ-inhaltsanalytischer Scope-Review der didaktischen Szenarien in Feedbackstudien vorgestellt, welcher das Ziel verfolgt, die Bandbreite an Implementierungen zu erfassen und eine Grundlage zur transparenten Beschreibung von Feedbackdesigns für zukünftige (Meta-)Studien zu schaffen. Hierzu wird eine Taxonomie entwickelt, die auf möglichst umfassende Weise unterschiedliche Umsetzungsvarianten abbilden soll. Daran anschliessend werden im Beitrag die Chancen und Grenzen eines qualitativ-inhaltsanalytischen Scope-Reviews zur Herausarbeitung von Taxonomien zur Beschreibung didaktischer Designs diskutiert.
The influence of perceived ESG and policy incentives on consumers’ intention to purchase new energy vehicles: Empirical evidence from China
Authors: Bian Xiangyu , Panyagometh Aweewan
Published: November 2023

The new energy vehicle industry has proliferated in the face of global climate change and challenges to sustainable development. Understanding the factors that encourage consumers to purchase new energy vehicles is essential to driving the new energy vehicle industry’s future development. Based on signaling theory, this study aims to investigate the significant influence of various factors, such as perceived ESG and policy incentives, on Chinese consumers’ intention to purchase new energy vehicles and explore the mediating effect of brand image and perceived value. This study adopts a quantitative research methodology by collecting data from 860 potential new energy vehicle consumers in China through a questionnaire survey and analyzing the data using structural equation modeling in AMOS 24.0. The results of the study show that consumers’ perceived ESG significantly affects their intention to purchase new energy vehicles. Brand image and perceived value mediate consumers’ perceived ESG factors and their purchase intention of new energy vehicles. Consumers’ positive attitudes will increase the purchase intention of new energy vehicles. In addition, government incentives also have a positive and significant effect on the intention to purchase new energy vehicles. These results provide sustainable marketing guidance for NEV companies, confirming the importance of good environmental, social, and governance performance, good brand image, and perceived benefits in driving purchases. In addition, this study provides empirical evidence of policy support for the NEV industry, thus reinforcing its importance for policymakers.
Exploring the nexus between economic growth and economic performance in Nepal
Authors: Mani Upadhyaya Yadav , Raj Kharel Khom , Kharel Suman , Dev Lamichhane Basu
Published: November 2023

This study aims to explore the relationship between economic growth and performance in Nepal, identifying key drivers for growth. Studying the nexus between economic growth and economic performance in Nepal is crucial for understanding how these factors interact within the nation’s specific context. Growth of gross domestic product (GDP) is represented as the primary indicator for evaluating economic performance, reflecting the overall well-being of a nation's economy. Economic performance encompasses a broader spectrum, including indicators such as employment rate, inflation, income distribution and overall economic stability. Using E-Views 10, a descriptive and analytical research approach has been applied to analyze time series secondary data from 1990–2021 using an econometric model. This study found that faster-growing economies typically experience increased jobs, higher investment, more exports, and often lower inflation. These relationships are part of a long-run equilibrium relationship. In the event of an economic shock disrupting this equilibrium, the economy tends to naturally return to the equilibrium over time. This study found that short-term causality running from lagged GDP, gross capital formation (GCF), exports, human development index (HDI), and employment ratio influence immediate GDP growth. These variables wield a short-term influence over GDP growth; for instance, a sudden surge in exports can prompt a temporary boost in economic growth. This indicates that there is a long-term sustained link between GDP growth and the independent variables rather than merely a short-term event.
Chemical Profile of Drug Infused Papers Seized in Rio de Janeiro (Brazil) Prisons During the COVID-19 Lockdown
Authors: de Oliveira Adriana , Antonio Ananda , Bhering Cecília , Wurzler Gleicielle , de Almeida Fernando , Carvalhosa Diego , de Oliveira Marco Antônio , de Aquino Neto Francisco , Costa Gabriela
Published: November 2023

Coronavirus disease (COVID-19) pandemic affected several business segments due to the lockdown period, including the illicit drug market. As Brazil usually imports new psychoactive substances (NPS), it was expected that their traffic would change during the pandemic. This study aimed to characterize NPS infused in pieces of paper seized inside prisons in the State of Rio de Janeiro (RJ), Brazil, during the COVID-19 pandemic by gas chromatography coupled with mass spectrometry, attenuated total reflectance-Fourier transform infrared spectroscopy, and high-resolution mass spectrometry. All samples were identified as synthetic cannabinoid receptor agonists, with indole-indazole structures. It was the first record of methyl (2S)-3,3-dimethyl-2-(1-(pent-4-en-1-yl)- 1H-indazole-3-carboxamido) butanoate (MDMB-4en-PINACA), N-[(2S)-1-amino-3,3-dimethyl1-oxobutan-2-yl]-1-butylindazole-3-carboxamide (ADB-BUTINACA), and N-(1-adamantyl)- 1-(4-fluorobutyl)indazole-3-carboxamide (4F-ABUTINACA) in RJ, demonstrating that new NPS still arrived despite the lockdown. The integration of the data obtained via this study enabled the unequivocal identification of NPS even in the absence of standard reference materials, which is a common drawback faced by forensic laboratories in the analysis of NPS.
Optimizing Coastal and Small Island Areas through Industrial Reclamation: An Examination through the Lens of Utilitarianism Theory
Authors: Faradillah Candra Vira
Published: November 2023

Indonesia, as the largest archipelagic country in the world with more than 17,000 islands, has the potential to become the world's maritime axis through optimizing marine resources. One of the policies taken was converting coastal areas and small islands as industrial reclamation areas. However, they faced several real problems and impacts. This research normatively analyzes the disharmony of reclamation regulations and the impact of policies on changing the function of coastal areas and small islands as industrial reclamation areas, focusing on the perspective of John Stuart Mill's utilitarianism theory. The research results show the absence of national law, which causes overlapping authority of agencies, a lack of harmony in perceptions between agencies, and a lack of specific regulations for reclamation requirements—judging from J.S.'s theory of utilitarianism. Mill, the current reclamation policy has not equally provided benefits and happiness because the negative impact is more significant than the expected positive. This research highlights the need for substantial improvements in the legal framework and implementation of reclamation policies to minimize negative impacts and increase positive contributions for stakeholders.Indonesia, sebagai negara Archipelagic terbesar di dunia dengan lebih dari 17.000 pulau, memiliki potensi untuk menjadi poros maritim dunia melalui optimalisasi sumber daya kelautan. Salah satu kebijakan yang diambil adalah alih fungsi wilayah pesisir dan pulau-pulau kecil sebagai kawasan reklamasi industri, namun, menghadapi sejumlah permasalahan dan dampak nyata. Penelitian ini secara normatif menganalisis disharmonisasi pengaturan reklamasi dan dampak kebijakan alih fungsi wilayah pesisir dan pulau-pulau kecil sebagai kawasan reklamasi industri, dengan fokus pada perspektif teori utilitarianisme John Stuart Mill. Hasil penelitian menunjukkan ketidakadaan hukum nasional yang menyebabkan tumpang tindih kewenangan instansi, kurangnya keselarasan persepsi antar instansi, dan kekurangan aturan khusus untuk persyaratan reklamasi. Ditinjau dari teori utilitarianisme J.S. Mill, kebijakan reklamasi saat ini belum memberikan kemanfaatan dan kebahagiaan secara merata, karena dampak negatifnya lebih besar dibandingkan dampak positif yang diharapkan. Penelitian ini menyoroti perlunya perbaikan substansial dalam kerangka hukum dan implementasi kebijakan reklamasi untuk meminimalkan dampak negatif dan meningkatkan kontribusi positif bagi pemangku kepentingan.
Regulatory Approaches and Strategies for Household Waste Pollution Management in the East River Flood Canal of Semarang City
Authors: Nirwana Muhammad Alfaruq
Published: November 2023

This article explores regulations and strategies for managing the impact of household waste pollution in the East River Flood Canal of Semarang City. Water, crucial for human and environmental well-being, faces pollution challenges due to human activities. The study focuses on Semarang, where household waste pollution, often discarded along riverbanks, poses environmental threats. Primary data is collected through field interviews, complemented by secondary legal materials using socio-legal research methods. Regional Regulation No. 6 of 2012 addresses waste management in Semarang, aiming to empower residents in waste utilization and economic value creation. Law Number 32 of 2009 emphasizes collaborative efforts to address environmental challenges. Identified impacts of waste pollution include air and water pollution, contributing to flooding. A SWOT analysis suggests strategies such as enhancing stakeholder support, advocating the vision and mission for integrated waste management, establishing communication forums, leveraging ward roles in community counselling, and enhancing resource capacity to shift public perceptions and behaviours in waste management. This research aims to contribute to sustainable waste management practices and environmental preservation. Artikel ini mengeksplorasi regulasi dan strategi pengelolaan dampak pencemaran limbah rumah tangga di Banjir Kanal Sungai Timur Kota Semarang. Air, yang sangat penting bagi kesejahteraan manusia dan lingkungan, menghadapi tantangan polusi akibat aktivitas manusia. Studi ini berfokus di Semarang, dimana pencemaran limbah rumah tangga, yang sering dibuang di sepanjang tepi sungai, menimbulkan ancaman terhadap lingkungan. Data primer dikumpulkan melalui wawancara lapangan yang dilengkapi dengan bahan hukum sekunder dengan menggunakan metode penelitian sosio-legal. Peraturan Daerah Nomor 6 Tahun 2012 mengatur tentang pengelolaan sampah di Kota Semarang yang bertujuan untuk memberdayakan warga dalam pemanfaatan sampah dan penciptaan nilai ekonomi. Undang-Undang Nomor 32 Tahun 2009 menekankan upaya kolaboratif untuk mengatasi tantangan lingkungan hidup. Dampak pencemaran limbah yang teridentifikasi meliputi pencemaran udara dan air, yang berkontribusi terhadap banjir. Analisis SWOT menyarankan strategi seperti meningkatkan dukungan pemangku kepentingan, mendukung visi dan misi pengelolaan sampah terpadu, membentuk forum komunikasi, memanfaatkan peran lingkungan dalam konseling masyarakat, dan meningkatkan kapasitas sumber daya untuk mengubah persepsi dan perilaku masyarakat dalam pengelolaan sampah. Penelitian ini bertujuan untuk berkontribusi pada praktik pengelolaan sampah berkelanjutan dan pelestarian lingkungan.
Egeria densa organic extracts: an eco-friendly approach to suppress Microcystis aeruginosa growth through allelopathy
Authors: Wijesinghe Ashika , Senavirathna Mudalige Don Hiranya Jayasanka , Fujino Takeshi
Published: November 2023

Macrophytes play a significant role in shaping plankton communities by shading, controlling water turbulence, and nutrient availability, while also producing allelochemicals causing varying effects on different organisms. Many researchers have shown that when live macrophytes are present, they inhibit cyanobacteria. However, their widespread use is often limited due to numerous concerns, including invasive characteristics. This study focused on the applicability of Egeria densa extracts to suppress Microcystis aeruginosa. We employed pure water and dimethyl sulfoxide, to obtain compounds from E. densa. The results revealed that E. densa aqueous extracts stimulated M. aeruginosa growth, whereas organic extracts exhibited suppression. Specifically, at low concentrations of organics extracts (0.5 and 1 g/L), after day 4, the growth inhibition was confirmed by significantly higher (p < 0.05) stress levels shown in cells treated with low concentrations. The highest inhibition rate of 32% was observed at 0.5 g/L. However, high concentrations of organic extracts (3 and 6 g/L), showed increased growth compared with control. These results suggest that high concentrations of organic extracts from E. densa potentially suppress allelochemical-induced M. aeruginosa inhibition due to high nutrient availability. In comparison with an aqueous solvent, the use of organic solvent seems to be more effective in efficiently extracting allelochemicals from E. densa.
Más allá de la austeridad. La historia no contada de los inmigrantes sirio-libaneses en Colombia (1880-1930)
Authors: Rhenals Doria Ana Milena
Published: November 2023

Este libro pretende reconstruir la trayectoria económica y social de la primera oleada\nde sirios y libaneses que hizo presencia en Colombia: su llegada a suelo colombiano a finales del siglo XIX, las actividades económicas a las que se\ndedicaron y su proceso de articulación en la esfera social durante las tres\nprimeras décadas del siglo XX. Específicamente, analiza la presencia e impacto\nque los inmigrantes sirio-libaneses tuvieron en la vida económica y social en espacios ubicados en las costas Caribe y Pacífica colombiana. Este estudio contribuye a repensar parte de este cuadro sobre la presencia de los sirio-libaneses en Colombia desde una triple perspectiva. En primer lugar, destaca la dinámica económica que caracterizaba a varios de los espacios donde se establecieron los sirio-libaneses, resaltando el auge económico que experimentaron estos espacios en el tránsito del siglo XIX al XX. En segundo lugar, resalta que existió una estrecha relación entre los mencionados inmigrantes y una serie de empresarios nacionales. Y, en tercer lugar, llamar la atención sobre la centralidad que el contrabando, el acaparamiento de tierra y la falsificación de monedas tuvieron en el posicionamiento económico de algunos de estos inmigrantes en Colombia.
BRINCADEIRA COMO ESPAÇO DE REFLEXÃO DIALÓGICA E FILOSÓFICA SOBRE CIÊNCIA E TECNOLOGIA NA EDUCAÇÃO INFANTIL
Authors: Flor Correa Felipe Luciana
Published: November 2023

O presente artigo tem por objetivo discutir como a brincadeira pode constituir-se num momento/espaço de reflexão dialógica e filosófica sobre Ciência e Tecnologia (C&T) na Educação Infantil. Para tanto, optou-se por realizar uma pesquisa de cunho bibliográfico, com caráter exploratório e descritivo visando obter um amplo conjunto de informações para a definição do quadro conceitual que envolve o objeto de estudo e o esclarecimento da problemática proposta. Nesse sentido, foi utilizada a abordagem qualitativa. O resultado principal aponta que na educação infantil a brincadeira, por suas características e peculiaridades, pode favorecer a reflexão dialógica e filosófica sobre C&T, pois no ato de brincar as crianças estabelecem múltiplas relações e interações e na convivência se descobrem e se constituem como seres sociais. Nesta perspectiva, a construção dialógica e filosófica de significados sobre C&T por meio da brincadeira proporciona a possibilidade de representar a realidade sem necessariamente ensinar – de forma tradicional – ciência ou conteúdos a ela inerentes, nem tampouco, introduzir complexos conceitos tecnológicos. Significa brincar com o produto da ciência e da tecnologia - brinquedos, jogos e afins – e, desta forma, estimular a curiosidade epistemológica.
Short Antimicrobial Peptides: Therapeutic Potential and Recent Advancements
Authors: Sharma Lalita , Bisht Gopal Singh
Published: November 2023

There has been a lot of interest in antimicrobial peptides (AMPs) as potential next-generation antibiotics.
They are components of the innate immune system. AMPs have broad-spectrum action and are less
prone to resistance development. They show potential applications in various fields, including medicine, agriculture,
and the food industry. However, despite the good activity and safety profiles, AMPs have had difficulty
finding success in the clinic due to their various limitations, such as production cost, proteolytic susceptibility,
and oral bioavailability. To overcome these flaws, a number of solutions have been devised, one of which
is developing short antimicrobial peptides. Short antimicrobial peptides do have an advantage over longer peptides
as they are more stable and do not collapse during absorption. They have generated a lot of interest because
of their evolutionary success and advantageous properties, such as low molecular weight, selective targets,
cell or organelles with minimal toxicity, and enormous therapeutic potential. This article provides an
overview of the development of short antimicrobial peptides with an emphasis on those with ≤ 30 amino acid
residues as a potential therapeutic agent to fight drug-resistant microorganisms. It also emphasizes their applications
in many fields and discusses their current state in clinical trials.
Recent Updates on the Development of Therapeutics for the Targeted
Treatment of Alzheimer’s Disease
Authors: Rajput Shivam , Malviya Rishabha , Bahadur Shiv , Puri Dinesh
Published: November 2023

Alzheimer's disease (AD) is a complicated, multifaceted, irreversible, and incurable neurotoxic old
age illness. Although NMDA (N-methyl D-aspartate)-receptor antagonists, cholinesterase repressors, and their
pairings have been approved for the treatment, they are useful for short symptomatic relief. Researchers
throughout the globe have been constantly working to uncover the therapy of Alzheimer's disease as new candidates
must be determined, and newer treatment medicines must be developed. The aim of this review is to address
recent advances in medication research along with new Alzheimer's disease therapy for diverse targets.
Information was gathered utilizing a variety of internet resources as well as websites, such as ALZFORUM
(alzforum.org) and clinicaltrials.gov. In contrast to other domains, the proposed medicines target amyloids
(secretases, A42 generation, neuroinflammation, amyloid precipitation, and immunization), tau proteins (tau
phosphorylation/aggregation and immunotherapy), and amyloid deposition. Despite tremendous advancement
in our understanding of the underlying pathophysiology of Alzheimer's disease, the FDA (Food and Drug Administration)
only approved aducanumab for diagnosis and treatment in 2003. Hence, novel treatment tactics
are needed to find and develop therapeutic medicines to combat Alzheimer's disease.
3D Printable Drug Delivery Systems: Next-generation Healthcare Technology
and Regulatory Aspects
Authors: Saxena Anmol , Malviya Rishabha
Published: November 2023

A revolutionary shift in healthcare has been sparked by the development of 3D printing, propelling
us into an era replete with boundless opportunities for personalized DDS (Drug Delivery Systems). Precise
control of the kinetics of drug release can be achieved through 3D printing, improving treatment efficacy and
patient compliance. Additionally, 3D printing facilitates the co-administration of multiple drugs, simplifying
treatment regimens. The technology offers rapid prototyping and manufacturing capabilities, reducing development
timelines and costs. The seamless integration of advanced algorithms and artificial neural networks (ANN)
augments the precision and efficacy of 3D printing, propelling us toward the forefront of personalized
medicine. This comprehensive review delves into the regulatory frontiers governing 3D printable drug delivery
systems, with an emphasis on adhering to rigorous safety protocols to ensure the well-being of patients by
leveraging the latest advancements in 3D printing technologies powered by artificial intelligence. The
paradigm promises superior therapeutic outcomes and optimized medication experiences and sets the stage for
an immersive future within the Metaverse, wherein healthcare seamlessly converges with virtual environments
to unlock unparalleled possibilities for personalized treatments.
Soluble Factors Associated with Denervation-induced Skeletal Muscle
Atrophy
Authors: Rodríguez Marianny Portal , Cabello-Verrugio Claudio
Published: November 2023

Skeletal muscle tissue has the critical function of mechanical support protecting the
body. In addition, its functions are strongly influenced by the balanced synthesis and degradation
processes of structural and regulatory proteins. The inhibition of protein synthesis and/or the activation
of catabolism generally determines a pathological state or condition called muscle atrophy,
a reduction in muscle mass that results in partial or total loss of function. It has been established
that many pathophysiological conditions can cause a decrease in muscle mass. Skeletal muscle innervation
involves stable and functional neural interactions with muscles via neuromuscular junctions
and is essential for maintaining normal muscle structure and function. Loss of motor innervation
induces rapid skeletal muscle fiber degeneration with activation of atrophy-related signaling
and subsequent disassembly of sarcomeres, altering normal muscle function. After denervation, an
inflammation stage is characterized by the increased expression of pro-inflammatory cytokines
that determine muscle atrophy. In this review, we highlighted the impact of some soluble factors
on the development of muscle atrophy by denervation.
Short-term Administration of Naringin Improves Renal Function in Renal Ischemia-reperfusion by Increasing Aquaporin-1 and Aquaporin-2 Levels
Authors: Demir Zubeyde , Acar Gozde , Dasdelen Dervis , Mogulkoc Rasim , Baltaci Abdulkerim Kasim
Published: November 2023

Background:

Since renal ischemia-reperfusion (I/R) can lead to a serious health problem,
aquaporins have important roles in preventing negative changes in electrolyte-water balance. This
study aimed to determine the effect of naringin treatment on renal function and AQP1 and AQP2
levels in the kidney cortex and medulla tissues in experimental renal I/R in rats.

Materials and Methods:

The study was carried out on 40 male Wistar-type rats, 8-12 weeks old. Experimental
groups were formed as follows: 1) Control, 2) Sham+vehicle, 3) Renal (I/R)+vehicle, 4)
Renal I/R+ Naringin (50mg/kg/day) (3 days of administration), and 5) Renal I/R+ Naringin(
100mg/kg/day) (3 days supplementation) group. First, the left kidney was removed by nephrectomy
under general anesthesia, and then the right kidney was subjected to 45 minutes of ischemia
and then 72 hours of reperfusion. Naringin was given to the experimental animals by an intraperitoneal
route at the beginning of the reperfusion, after 24 and 48 hours. At the end of the experiments,
first of all, blood samples were taken from the heart in animals under general anesthesia, and then the
animals were killed by cervical dislocation, and kidney tissue samples were taken. Osmolarity in
plasma and urine and plasma creatinine levels were evaluated. AQP1 and AQP2 levels were analyzed
in the kidney cortex and medulla tissues by ELISA and PCR methods.

Results:

In kidney tissues, I/R led to a decrease in plasma and urinary osmolality, AQP1 and AQP2
levels in the cortex and medulla, and an increase in urea and creatinine levels (p < 0.001). However,
naringin supplementation corrected the deterioration to a certain extent.

Conclusion:

The results of the study show that naringin supplementation at different doses, such as
50 or 100 mg/kg, may have protective effects on the deterioration of renal function caused by unilateral
nephrectomy and I/R in rats.
A Review of the Occurrence of Rheumatoid Arthritis and Potential
Treatments through Medicinal Plants from an Indian Perspective
Authors: Shekh Mohammad Raeesh , Ahmed Nasir , Kumar Vivek
Published: November 2023

Arthritis is a medical condition that affects the joints and causes inflammation, pain,
and stiffness. There are different types of arthritis, and it can affect people of all ages, even infants
and the elderly. Recent studies have found that individuals with diabetes, heart disease, and
obesity are more likely to experience arthritis symptoms. According to the World Health Organization,
over 21% of people worldwide suffer from musculoskeletal problems. Roughly 42.19 million
individuals in India, constituting around 0.31% of the populace, have been documented as
having Rheumatic Arthritis (RA).

:

Compared to other common diseases like diabetes, cancer, and AIDS, arthritis is more prevalent
in the general population. Unfortunately, there is no specific cure for arthritis, and treatment plans
usually involve non-pharmacological methods, surgeries, and medications that target specific
symptoms. Plant-based remedies have also been shown to be effective in managing inflammation
and related complications. In addition to therapies, maintaining a healthy diet, exercise, and
weight management are essential for managing arthritis.

:

This review discusses the causes, prevalence, diagnostic methods, current and prospective future
treatments, and potential medicinal plants that may act as anti-inflammatory or anti-rheumatic
agents. However, more research is necessary to identify the underlying mechanisms and active
molecules that could improve arthritis treatment.
Dengue Fever Virus Envelope Glycoproteins Variability Characterized
Bioinformatically
Authors: Polanco Carlos , Uversky Vladimir N. , Huberman Alberto , Hernandez-Lemus Enrique , Rios Castro Martha , López Oliva Erika Jeannette , Martínez-Garcia Mireya , Buhse Thomas , Roldan Gomez Francisco J. , Vargas-Alarcon Gilberto , Zazueta Cecilia , Pimentel-Hernández Claudia
Published: November 2023

Background:

The infection caused by the dengue fever virus is a severe threat to public
health on a global scale; nevertheless, there is currently no effective medical treatment or vaccine
available to prevent or treat the condition.

Objective:

To better understand the physicochemical regularities of these proteins, it is necessary to
carry out a computational multiparametric study of the amino acid sequences of envelope proteins
expressed by the dengue fever virus and obtain a bioinformatics method that can use the subsequences
of the training protein group to figure out the preponderant function of a protein, up to its
sequence.

Methods:

Essentially, at the amino acid level, various computational programs were applied to the
sequences expressing the dengue virus envelope glycoproteins to determine the PIM 2.0 v profile
and the Protein Intrinsic Disorder Predisposition (PIDP) profile of each protein, and then, at the nucleotide
level, a set of programs for genomic analysis was applied. Finally, these results were contrasted
with statistical tests.

Results:

The re-creation of structural morphological similarities provided by specific regularities in the
PIM 2.0 v profile and PIDP of the proteins from diverse dengue fever virus envelopes made it possible
to propose a computer method that employs the PIM 2.0 v profile to identify this group of proteins
based on their sequences; based on our findings, this method is a "fingerprint" of this protein group.

Conclusions:

The typical PIM 2.0 v profiles of the dengue fever virus proteins might be reproduced
by computational tools. This knowledge will be helpful in gaining a better understanding of the newly
discovered virus. Moreover, the method introduced here can identify, from the sequence, the
predominant function of the protein.
An Overview of Antihistamines and their Properties used for Treatment of
Different Diseases
Authors: Chaudhari Riya , Gosavi Seema , Bornare Pratiksha , Sonawane Saurabh , Ahire Tejas
Published: November 2023

Background:

By comparing the histamine impact to the instant response to an injected foreign protein in previously sensitized animals, one might hypothesize that histamine may be involved in this reaction. Through all four of the recognized types of histamine receptors, histamine is also essential for the control of immunological function and acute and chronic allergic inflammation.

Methods:

Recent evidence points to anti-IgE antibodies and specific antibodies to cytokines like IL-4 or IL-5 that are associated with allergic inflammation as probable causes of Allergic Rhinitis. The therapeutic advantage of antihistamines is a decrease in allergy symptoms and any other allergy-related symptoms. We research the many diseases and dose forms in which antihistamines are used. Pediatric age groups have never been thoroughly studied for first-generation antihistamines. Oral antihistamines are suggested as the first line of therapy for people with mild to severe intermittent Allergic Rhinitis symptoms.

Results:

Currently, approximately 100 different antihistamine-containing medicines and
around 20 different H1-receptor antagonists are available for therapeutic use. Antihistamines
of the second generation are more efficient and secure than those of the first generation. We
conducted a research on the sedative and non-sedative effects of antihistamines used to treat
various diseases.

Conclusion:

The present investigation highlights the use of antihistamines in various diseases at different ages, their sedative and non-sedative effect, and their utility in treating insomnia based on their safety and current use among the patient population, as well as our observation.
Evaluation of the Capparis Herbacea Willd's Chemistry, Antioxidant and Cytotoxic Activity
Authors: Tleuberlina Orynbassar , Mamurova Asem , Iskakova Zhanar , Aibuldinov Yelaman , Kolpek Ainagul , Kopishev Yeldar , Satbaeva Gulbarshyn , Mukazhanova Zhazira , Kurmanbayeva Meruyert
Published: November 2023

Background::

The Capparidaceae family includes the medicinal herb Capparis her-bacea Willd. The aerial and underground parts of plant C.herbacea were studied for their chemical composition, antioxidant, and cytotoxic properties

Methods:

Using gas chromatography with mass spectrometric detection (7890A/5975C), 94 chemicals were identified in ethanol extract from leaves, roots, seeds, and stems of C. her-bacea. Main components were (leaves) phytol 18.16%, hexanedioic acid, bis(2-ethylhexyl) ester 16.75%, vitamin E 11.95%, (roots) sucrose 13.94%, hexadecanoic acid, ethylester 22.80%, octadecanoic acid, ethylester 37.77%; (seeds) hexadecanoic acid, ethylester 13.96%, ethyl9.cis.,11.trans.-octadecadienoate 48.54%, bis(2-ethylhexyl) phthalate 9.77%; (stems) 1-propene-1,2,3-tricarboxylic acid, tributyl ester 42.69%, and tributylacetylcitrate 19.63%. Nine components were identified in the makeup of the C. herbacea sample's essential oil using the method of chromatography-mass spectrometry.

Results::

The main components were (in%): T-cadinol (29.56), meta-cymene (16.12), pulegone (14.11), and σ-amorphene (12.26). Chloroform and methanol extracts of Capparis herbacia roots at concentrations of 1 mg/ml showed higher average antioxidant activity, while ethyl acetate root extract at concentrations of 0.75 and 1 mg/ml showed higher average antioxidant activity compared to gallic acid AOA.

Conclusion::

In addition, plant extracts have cytotoxic activity. Essential oils of leaves and stems, fruit and roots of Capparis herbacia plants exhibited cytotoxicity, all larvae died, and larval mortality was 96%.
Role of Nanomedicine for Targeted Drug Delivery in Livestock: Future
Prospective
Authors: Hooda Neeti , Ahlawat Aarti , Kumari Puja , Alam Md. Sabir , Ansari Jamilur R.
Published: November 2023

Nanotechnology has advanced significantly in recent years and is currently used in a wide
range of sectors. Only a handful of the many diverse issues covered by nanotechnology include nanoscale
gadgets, nanomaterials, nanoparticles, and nanomedicines. Its performance in treating a
range of grave conditions, such as cancer, early detection of infections, analysis, bio-imaging, and
bio sensing, suggests that it is highly advanced. Nanoscale materials have been employed for medicine
delivery, pharmaceutics, and a range of diagnostic techniques due to their various biochemical
and physical features. The use of nanoparticles that are based on nanotechnology can significantly
improve the drug delivery mechanism. It is believed that nanoparticles capacity to improve the stability
and solubility of drugs and shield them from impulsive inactivation during drug transfer makes
it possible for them to capture, encapsulate, or bond with the molecules. The use of nanomedicine or
nanoparticle-based tactics to combat viruses has emerged as a potentially life-saving tactic. These
approaches have the power to protect both humans and animals against viruses. In order to inactivate
a virus, nanoparticles have the unique capacity to connect with the virus epitope. Many nanocarriers
have the potential to replace current drug delivery methods with focused drug delivery. Small dosages,
low toxicity, and targeted flow of drug release at the infected location are all characteristics of
nanocarriers or nanomedicine. Due to their distinct physicochemical and biological features, nanomaterial-
based drug delivery systems (NBDDS) are frequently employed to enhance the safety and
therapeutic efficacy of encapsulated pharmaceuticals. The program’s objective can be supported by
the applications that have so far been developed. This idea is therefore essential and sophisticated for
the development of civilization. Our research will therefore concentrate on how human use of nanomedicines
has changed through time in many domains.