bluuebunny/crossref_metadata_2025 huggingface dataset:
A review of the predictors of antimicrobial use and resistance in European food animal production
Authors: Redman-White Carys J. , Moran Dominic , Peters Andrew R. , Muwonge Adrian
Published: August 2023

Antimicrobial resistance (AMR) is a major threat to global health and a key One Health challenge linking humans, animals, and the environment. Livestock are a key target for moderation of antimicrobial use (AMU), which is a major driver of AMR in these species. While some studies have assessed AMU and AMR in individual production systems, the evidence regarding predictors of AMU and AMR in livestock is fragmented, with significant research gaps in identifying the predictors of AMU and AMR common across farming systems. This review summarizes existing knowledge to identify key practices and critical control points determining on-farm AMU/AMR determinants for pigs, layer and broiler hens, beef and dairy cattle, sheep, turkeys, and farmed salmon in Europe. The quality and quantity of evidence differed between livestock types, with sheep, beef cattle, laying hens, turkeys and salmon underrepresented. Interventions to mitigate both AMU and/or AMR highlighted in these studies included biosecurity and herd health plans. Organic production typically showed significantly lower AMU across species, but even in antibiotic-free systems, varying AMR levels were identified in livestock microflora. Although vaccination is frequently implemented as part of herd health plans, its effects on AMU/AMR remain unclear at farm level. Social and behavioral factors were identified as important influences on AMU. The study fills a conspicuous gap in the existing AMR and One Health literatures examining links between farm management practices and AMU and AMR in European livestock production.
Geometric Anatomy Basis for Safe and Effective Focal Ablation of Prostate Cancer by Irreversible Electroporation (IRE)
Authors: Cussenot Olivier , Macpherson Ruth , Leslie Tom , Lunelli Luca , Marra Giancarlo , Laniado Marc , Hamdy Freddie C. , Bryant Richard J.
Published: August 2023

Irreversible electroporation (IRE) is a recent and minimally invasive method of partial prostate ablation. However, knowledge of the essential landmarks of prostate anatomy is crucial to achieving safe and effective partial ablation by IRE. High-quality imaging of the prostate is essential before the procedure. The individual morphological pattern of the prostate must be taken into account and detailed mapping with measurement of the lesion is necessary to determine optimal needle placement. The entire tumour volume must be covered while ensuring the safety of critical anatomical structures such as the rectum, urethra, nerve bundles and sphincter muscle.
Microstructural Characterization of High-Protein Dairy Powders
Authors: Salunke Prafulla , Syamala Athira , Metzger Lloyd E.
Published: August 2023

Dairy proteins are potential and multipurpose ingredients used to prepare various food products. It exhibits many beneficial functionalities and bioactivities in the processing of food products. All the functionalities of different dairy proteins depend on their peculiar structural characteristics. So, the present study aimed to characterize high-protein powders with different matrices (milk protein concentrate (MPC), rennet casein (RCN), micellar casein concentrate (MCC), whey protein isolate (WPI), and native whey concentrate (NWC)) for their composition, handling, and reconstitution properties, and microstructure and compared them with whole milk powder (WMP) and skim milk powder (SMP). The bulk density of the high-protein powders was significantly (p < 0.05) lower than WMP and NFDM. Due to the low bulk density of the high-protein powders, the wettability of these powders in the water was very high. Microstructural analysis of powders by scanning electron microscopy reveals that the high-protein powder had tetrahedron-to-polyhedron-shaped particles depending on the protein level. The idea regarding the powder’s morphology might be helpful for further improvement in the production processes to modify the functional properties of high-protein milk powders.
Increased Occurrence of Cutaneous Leiomyomas and Dermatofibromas in Patients with Uterine Leiomyomas without Fumarate Hydratase Gene Mutations
Authors: Campione Elena , Di Prete Monia , Costanza Gaetana , Saggini Andrea , Agostinelli Sara , Terrinoni Alessandro , Centofanti Federica , Rapanotti Maria Cristina , Bianchi Luca , Ferlosio Amedeo , Scioli Maria Giovanna , Orlandi Augusto
Published: August 2023

Leiomyomas are smooth muscle-derived benign neoplasms that can affect all organs, most frequently in the uterus. Fumarate hydratase gene (FH) mutation is characterised by an autosomal dominant disease with increased occurrence of renal tumours, but also by cutaneous (CLs) and uterine leiomyomas (ULs). So far, an increased occurrence of skin tumours in non-mutated patients with ULs has not been verified. To this aim, a case-group of women who were FH non-mutated patients surgically treated for ULs (n = 34) was compared with a control-group (n = 37) of consecutive age-matched healthy women. The occurrence of skin neoplasms, including CLs and dermatofibromas (DFs), was evaluated. Moreover, the microscopic features of FH non-mutated skin tumours were compared with those of an age-matched population group (n = 70) who presented, in their clinical history, only one type of skin tumour and no ULs. Immunohistochemical and in vitro studies analysed TGFβ and vitamin D receptor expression. FH non-mutated patients with ULs displayed a higher occurrence of CLs and DFs (p < 0.03 and p < 0.001), but not of other types of skin tumours. Immunohistochemistry revealed a lower vitamin D receptor (VDR) expression in CLs and DFs from the ULs group compared with those from the population group (p < 0.01), but a similar distribution of TGFβ-receptors and SMAD3. In vitro studies documented that TGFβ-1 treatment and vitamin D3 have opposite effects on α-SMA, TGFβR2 and VDR expression on dermal fibroblast and leiomyoma cell cultures. This unreported increased occurrence of CLs and DFs in FH non-mutated patients with symptomatic ULs with vitamin D deficiency suggests a potential pathogenetic role of vitamin D bioavailability also for CLs and DFs.
Recent Advances toward Carbon-Neutral Power System
Authors: Astero Poria
Published: August 2023

The pursuit of a carbon-neutral society has emerged as a global imperative in the face of escalating environmental challenges [...]
Emerging Trends in Nanomaterial-Based Biomedical Aspects
Authors: Gandhi Mansi , Amreen Khairunnisa
Published: August 2023

Comprehending the interfacial interaction of nanomaterials (NMs) and biological systems is a significant research interest. NMs comprise various nanoparticles (NPs) like carbon nanotubes, graphene oxides, carbon dots, graphite nanopowders, etc. These NPs show a variety of interactions with biological interfaces via organic layers, therapeutic molecules, proteins, DNA, and cellular matrices. A number of biophysical and colloidal forces act at the morphological surface to regulate the biological responses of bio-nanoconjugates, imparting distinct physical properties to the NMs. The design of future-generation nano-tools is primarily based on the basic properties of NMs, such as shape, size, compositional, functionality, etc., with studies being carried out extensively. Understanding their properties promotes research in the medical and biological sciences and improves their applicability in the health management sector. In this review article, in-depth and critical analysis of the theoretical and experimental aspects involving nanoscale material, which have inspired various biological systems, is the area of focus. The main analysis involves different self-assembled synthetic materials, bio-functionalized NMs, and their probing techniques. The present review article focuses on recent emerging trends in the synthesis and applications of nanomaterials with respect to various biomedical applications. This article provides value to the literature as it summarizes the state-of-the-art nanomaterials reported, especially within the health sector. It has been observed that nanomaterial applications in drug design, diagnosis, testing, and in the research arena, as well as many fatal disease conditions like cancer and sepsis, have explored alongwith drug therapies and other options for the delivery of nanomaterials. Even the day-to-day life of the synthesis and purification of these materials is changing to provide us with a simplified process. This review article can be useful in the research sector as a single platform wherein all types of nanomaterials for biomedical aspects can be understood in detail.
Synthesis of Porous Activated Carbon Doped with Tetramethylammonium Hydroxide: Evaluation of Excellent Gasoline Vapor Adsorption Performance and Activation Mechanism
Authors: Wu Chenyu , Yang Jing , Gong Yu , Ju Yongming , Tao Jiahui , Jiang Xinmeng
Published: August 2023

The rapid urbanization and industrialization in China have led to an urgent dilemma for controlling urban air pollution, including the intensified emission of gasoline vapor into the atmosphere. Herein, we selected highland barley straw as a raw material and KOH and tetramethylammonium hydroxide (TMAOH) as activators to synthesize nitrogen-doped layered porous carbon (K-thAC) by a three-step activation method. The obtained K-thAC materials had a high specific surface area, reaching 3119 m2/g. Dynamic adsorption experiments demonstrated a superior adsorption capacity of up to 501 mg/g (K-thAC-25) for gasoline vapor compared with other documented carbon adsorbents. Moreover, adjusting the ratio of raw materials with a series of active ingredients could further improve the pore properties of the obtained K-thACs and their adsorption performance for gasoline vapor. Furthermore, the K-thAC materials were also characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), synchronous thermogravimetry (STA), X-ray powder diffraction (XRD), energy dispersive spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), and nitrogen adsorption tests. This study synthesized a novel plant-based material to treat gasoline vapor pollution efficiently.
Novel 7-Deazapurine Incorporating Isatin Hybrid Compounds as Protein Kinase Inhibitors: Design, Synthesis, In Silico Studies, and Antiproliferative Evaluation
Authors: Alanazi Mohammed M. , Alanazi Ashwag S.
Published: August 2023

Cancer is a multifactorial disorder with extremely complex genetics and progression. The major challenge in cancer therapy is the development of cancer resistance and relapse. Conventional anticancer drugs directly target the DNA of the cell, while modern chemotherapeutic drugs include molecular-targeted therapy, such as targeting the abnormal cell signaling inside the cancer cells. Targeted chemotherapy is effective in several malignancies; however, the success has always been limited by drug resistance and/or side effects. Anticancer with multi-targeted actions simultaneously modulates multiple cancer cell signaling pathways and, therefore, may ease the chance of effective anticancer drug development. In this research, a series of 7-deazapurine incorporating isatin hybrid compounds was designed and successfully synthesized. Among those hybrids, compound 5 demonstrated a very potent cytotoxic effect compared to the reference anticancer drug against four cancer cell lines. Likewise, compound 5 inhibited the activity of four protein kinase enzymes in nanomolar ranges. Further analysis of the biological evaluation of compound 5 revealed the capability of compound 5 to arrest cell cycle progression and induce programmed cell death. Moreover, molecular simulation studies were performed to investigate the possible types of interactions between compound 5 and the investigated protein kinases. Finally, taking into consideration all the abovementioned findings, compound 5 could be a good candidate for further investigations.
Special Issue “Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds II”
Authors: Silva Vera L. M. , Silva Artur M. S.
Published: August 2023

Pyrazole and its derivatives are considered privileged N-heterocycles with immense therapeutic potential [...]
Porphyrin-Based MOF Thin Film on Transparent Conducting Oxide: Investigation of Growth, Porosity and Photoelectrochemical Properties
Authors: Gikonyo Ben , Liu Fangbing , Hawila Saly , Demessence Aude , Baldovi Herme G. , Navalón Sergio , Marichy Catherine , Fateeva Alexandra
Published: August 2023

Synthesizing metal-organic frameworks (MOFs) composites with a controlled morphology is an important requirement to access materials of desired patterning and composition. Since the last decade, MOF growth from sacrificial metal oxide layer is increasingly developed as it represents an efficient pathway to functionalize a large number of substrates. In this study, porphyrin-based Al-PMOF thin films were grown on conductive transparent oxide substrates from sacrificial layers of ALD-deposited alumina oxide. The control of the solvent composition and the number of atomic layer deposition (ALD) cycles allow us to tune the crystallinity, morphology and thickness of the produced thin films. Photophysical studies evidence that Al-PMOF thin films present light absorption and emission properties governed by the porphyrinic linker, without any quenching upon increasing the film thickness. Al-PMOF thin films obtained through this methodology present a remarkably high optical quality both in terms of transparency and coverage. The porosity of the samples is demonstrated by ellipsometry and used for Zn(II) insertion inside the MOF thin film. The multifunctional transparent, porous and luminescent thin film grown on fluorine-doped tin oxide (FTO) is used as an electrode capable of photoinduced charge separation upon simulated sunlight irradiation.
Neuroimaging diagnostics of stress-related mental disorders
Authors:   FSBMEI HE S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Shamrey V.K. , Khritinin D.F. ,   FSAEI HE I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Tarumov D.A. ,   FSBMEI HE S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Markin K.V. ,   FSBMEI HE S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Trufanov A.G. ,   FSBMEI HE S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Puchkov N.A. ,   FSBMEI HE S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Abdulaev Sh.K. ,   FSBMEI HE S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Kuznetsov K.S. ,   FSBMEI HE S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg
Published: August 2023

Modern wars and military conflicts are characterized by a high prevalence of mental traumatization due to military operations, which leads to an increase in the frequency of stress-related mental disorders formation. In this regard, the development of algorithm for therapeutic and diagnostic support of patients with this pathology at different stages of medical care, using the results of modern research methods, including neuroimaging data, is extremely relevant. The paper presents the results of neuroimaging diagnostics of post-traumatic stress disorders, describes its methodology, and highlights the changes in the functional connectivity of the brain in the examined patients compared with the control group.
Real estate product manager role
Authors: Rodionova Yuliya V.
Published: August 2023

The methodology of creating, supporting and implementing investment projects in construction has undergone many changes, from the use of industrial technologies of the late 20th century with strict compliance on standards of livability to the analogues of foreign premium projects with bright advertising slogans. Currently, development is experiencing the need to form a holistic image of the product, precisely tailored to the needs and interests of the end consumer. Similar to the project management in IT and FMCG sectors, there is a demand in real estate development for a new role unit - product manager or a productologist. The article provides a rationale for the proposed functional model of a specialist who will give a new impetus to development companies and enrich the benefits of development projects with exactly those values which form a comfortable and environmentally friendly urban environment.
Theoretical aspects of mandatory reservation asa tool of monetary regulation
Authors: Kropin Yuriy A.
Published: August 2023

The relevance of the topic of the article is due to the need to bring the instruments of regulatory activity of the central bank into line with the essence of the modern monetary system. This general theoretical imperative is considered in the article in relation to such an instrument of monetary regulation as the obligatory reserve of a part of the liabilities of commercial banks on correspondent accounts with the central bank. The purpose of the article is to find an answer to the question of how this tool, on the one hand, is scientifically based, and on the other hand, it meets the interests of commercial banks and the interests of the country (market\) as a whole. As a result of the study, it is concluded that this instrument does not correspond to the essence of the modern monetary system and does not meet the interests of commercial banks, national interests and, in fact, the interests of the central bank itself. As a result, a conclusion is made about the need for a radical transformation of this instrument of regulatory activity of the central bank. The methods of comparative analysis, deduction and induction, the method of historical and logical unity and a number of other scientific methods were used in the work.
Hablar desde la entraña: humanismo, nación y condición femenina en Yolanda Bedregal
Authors: Riobó Pezoa Enrique
Published: August 2023

El presente artículo busca argumentar sobre la relevancia de la antigüedad griega y precolombina para pensar tópicos relevantes de la obra de Yolanda Bedregal como el humanismo –vinculado al problema del conocimiento–, la nación y la condición femenina. El artículo se divide en cuatro partes. Una breve introducción; una selección de referencias a la antigüedad; un diálogo entre el problema del conocimiento, la condición femenina y el arte; y la noción de entraña como relación problemática con la nación. Se pone énfasis en las distintas formas en que Bedregal dice sin decir.
La construcción visual de la ciudad de La Paz, según Bolivia Films
Authors: Zapata Pinto L. Sergio
Published: August 2023

El análisis de esta pieza cinematográfica es parte de un corpus analítico más amplio que abarca la producción del Instituto Cinematográfico Boliviano (ICB), cuyas películas y noticieros tienen profundos parentescos con la obra de Bolivia Films Ltd.
Tres indigenismos a través de periódicos y revistas literarias y culturales (1930-1950)
Authors: Rocha Velasco Pedro Omar
Published: August 2023

Éste es un fragmento del texto leído en el evento “Artistas en diálogo, Juan Rimsa y su tiempo”, realizado entre el 25 y 26 de marzo de 2019; no se publica, por falta de espacio, la tercera parte llamada “Reververaciones del Titikaka”.

En este texto recupero la resemantización propuesta por Rosario Rodríguez en su tesis doctoral sobre el indigenismo literario boliviano y latinoamericano: “un espacio de articulación que, atravesando demarcaciones rigurosas, permita seguir el hilo a esas manifestaciones discursivas donde se confrontan, encuentran, interpelan, rechazan, comprometen diversidades heterogéneas, a partir de esa oposición radical primera entre mundo indio/mundo occidental del indigenismo clásico. Pretendo respetar la multiplicidad y divergencia de una secuencia artística no uniforme y no caer en la visión única de un proceso lineal” (2008, pp. 8-9).
La historia indígena en Santa Cruz: usos, abusos y enseñanzas
Authors: Combès Isabelle
Published: August 2023

Olvidada o despreciada por mucho tiempo, la historia indígena empezó a posicionarse con fuerza en Santa Cruz durante las últimas décadas. Sin embargo, suele ser objeto de una instrumentalización ideológica que sólo “tritura” el pasado para oponer una identidad “camba” u oriental a otra andina. En contraposición, las investigaciones más profesionales evidencian la diversidad étnica de Santa Cruz, sus lazos con regiones y países vecinos y una historia compartida entre indígenas y criollos que constituye la verdadera riqueza cultural e histórica de la región.
Orígenes del modelo de desarrollo cruceño: el Comité de Obras Públicas y la Corporación de Desarrollo de Santa Cruz
Authors: Traverso-Krejcarek Ana Carola
Published: August 2023

El modelo de desarrollo cruceño es uno de los fenómenos de transformación más importantes de Bolivia, dada su adaptación, resiliencia y participación a escala regional. Basado en la habilidad de asociación y planificación a partir del sistema cívico e institucional, el modelo de desarrollo cruceño se ha mantenido activo a lo largo de tiempo. Pero este modelo también ha sufrido mutaciones considerables, que es necesario señalar. Este ensayo busca explorar los orígenes del modelo de desarrollo cruceño, analizando su estructura, sus logros y su impacto. Se busca sistematizar sus principales contribuciones a la historia política y económica del país.
Violencia y deshumanización del cuerpo: una lectura del body horror en “Subasta” de María Fernanda Ampuero
Authors: Aguilar González Metztli Donají
Published: August 2023

Debido a su escritura atroz y temas de lo perverso, María Fernanda Ampuero se ha convertido en una de las voces literarias más importantes de Ecuador y Latinoamérica. Su cuento “Subasta” contenido en Pelea de gallos (2018), sobresale de entre el resto porque en él se configura un universo de violencia masculina y traumas de la infancia que propician la intervención del cuerpo femenino hasta llevarlo al rango del body horror (horror corporal), un acto que trastoca los límites de lo monstruoso, lo repugnante y lo indeseable como última alterativa de emancipación en la esfera del abuso patriarcal.
Entre ansibles y pantallas: la programación del yo “En Proceso” de Andrea Chapela
Authors: Romano Hurtado Berenice 
Published: August 2023

En este artículo se revisan los cruces narrativos entre la autoficción y la ciencia ficción en el cuento “En proceso” de Andrea Chapela. La construcción y pregunta por un yo adquiere matices interesantes cuando se refiere a una conciencia rescatada por una computadora. Los temas tradicionales de las escrituras del yo -la memoria, la escritura que combate el olvido, el recuento de vida, la verdad y la mentira, la muerte y la inmortalidad- se piensan en el marco de un relato escrito al modo de una autoficción, pero en el contexto de una sociedad hipertecnologizada que modifica la percepción de los sujetos así como la relación con el sí mismo.
Pengaruh Kegiatan Membatik dengan Media Tisu Terhadap Kemampuan Motorik Halus Anak Kelompok A di RA Muslimat NU 151 Manarotul Ulum
Authors: Wulandari Lisfi , Simatupang Nurhenti Dorlina
Published: August 2023

The main focus in this reseacrh is fine motor skills. Conditions in the scope show that in the folding activity it is still not symmetrical, when stamped batik is still not flexible in moving its hand movements. One of the fine motor skill stimulation that can be given to children is batik activities using tissue media. This reseacrh was used to measure the effect of batik activities using tissue media on the fine motor skills of group A children at RA Muslimat NU 151 Manarotul Ulum. This type of research is quantitative Quasi Experimental with a Nonequivalent Control Group Design. The samples in this study were group A children at RA Muslimat NU 151 Manarotul Ulum (experimental group) and group A1 children at RA YKUI Sambogunung (kontrol group). The data collection techniques are observation and documentation. The data analysis technique uses an independent sample T test with IBM SPSS Statistics 25. The test results show that the significance value of (2-tailed) is 0.023 <0.05, so Ha is accepted and H0 is rejected. This activities treatment (batik using tissue media) has an  effect on the fine motor skills of group A children at RA Muslimat NU 151 Manarotul Ulum. 
ABSTRAK 
Fokus utama pada penelitian ini yaitu motorik halus. Kondisi di lapangan menunjukkan bahwa dalam kegiatan melipat masih kurang simetris, saat kegiatan membatik cap masih kurang luwes dalam menggerakkan gerakan tangannya. Salah satu stimulasi motorik halus yang dapat diberikan kepada anak adalah kegiatan membatik dengan media tisu. Penelitian ini bertujuan untuk mengukur pengaruh kegiatan membatik dengan media tisu terhadap kemampuan motorik halus anak kelompok A di RA Muslimat NU 151 Manarotul Ulum. Jenis penelitian ini adalah kuantitatif Quasi Eksperimental dengan rancangan Nonequivalent Kontrol Group Design. Sampel pada penelitian ini adalah anak kelompok A di RA Muslimat NU 151 Manarotul Ulum (kelompok eksperimen) dan anak kelompok A1 di RA YKUI Sambogunung (kelompok kontrol). Teknik pengumpulan datanya yaitu observasi dan dokumentasi. Teknik analisis datanya menggunakan uji independent sample T test dengan IBM SPSS Statistics 25. Hasil uji tersebut diperoleh bahwa nilai signifikansi (2-tailed) yaitu 0.023 < 0.05 maka Ha diterima dan H0 ditolak. Jadi, terdapat pengaruh treatment kegiatan membatik dengan media tisu terhadap kemampuan motorik halus anak kelompok A di RA Muslimat NU 151 Manarotul Ulum.
How can ChatGPT Support Teachers and Students in Vietnamese Civic Education
Authors: Yến Cao Thị Hải , Lệ Cao Mỹ , Cao Linh
Published: August 2023

The rapid advancement of artificial intelligence (AI) technologies has presented new opportunities to enhance education across various subjects, including Civic Education. In the context of Vietnamese high schools, the integration of AI language models like ChatGPT can provide valuable support to both teachers and students in their learning journey. This paper explores the potential benefits of using ChatGPT as a supplementary tool to promote interactive learning, foster critical thinking, and facilitate access to relevant resources in Vietnamese Civic Education.
PENGEMBANGAN LKPD BERBASIS LEARNING CYCLE 7E PADA MATERI SISTEM REPRODUKSI UNTUK MENINGKATKAN HASIL BELAJAR SISWA KELAS XI SMA
Authors: Fadillah Nur , B Nurhayati , Bahri Arsad
Published: August 2023

Penelitian ini bertujuan untuk menghasilkan bahan ajar berupa LKPD berbasis Learning Cycle 7E pada materi sistem reproduksi manusia yang bersifat valid, praktis dan efektif. Subjek penelitian adalah guru biologi dan peserta didik kelas XI MIPA 1 di SMAN 7 Pinrang. Jenis penelitian ini adalah penelitian dan pengembangan (R&D) yang mengadaptasi model pengembangan ADDIE (Analysis, Design, Development, Implementation, Evaluation). Data kevalidan diperoleh melalui lembar validasi instrumen penelitian pada materi sistem reproduksi manusia, data kepraktisan diperoleh melalui angket respon guru dan angket respon peserta didik, dan data keefektifan diperoleh melalui tes hasil belajar peserta didik. Data yang diperoleh dari hasil penelitian dianalisis dengan menggunakan analisis statistik deskriptif. Hasil analisis menunjukkan bahwa nilai rata-rata total kevalidan pengembangan produk berada pada kategori sangat valid (4,54). Hasil respon memenuhi kriteria kepraktisan karena rata-rata respon peserta didik terhadap pengembangan produk berada pada kategori sangat parktis (88,39%) dan rata rata nilai respon guru terhadap pengembangan produk berada pada kategori sangat praktis (81,33%). Pengembangan produk memenuhi kriteria keefektifan karena jumlah peserta didik yang memperoleh nilai rata-rata N-Gain sebesar 0,68 yang berada pada kategori sedang dan untuk persentase ketuntasan hasil belajar peserta didik berada pada kategori sangat efektif (86,20%). Sehingga dapat disimpulkan bahwa LKPD berbasis Learning Cycle 7E yang dikembangkan menggunakan model pengembangan ADDIE memenuhi kriteria valid, praktis, dan efektif serta dapat meningkatkan hasil belajar peserta didik.
Pengaruh Kecerdasan Adversitas, Perhatian Orangtua dan Efikasi Diri Terhadap Hasil Belajar Biologi Siswa Kelas XI MIA SMAN Se-Kabupaten Tana Tidung
Authors: Arni Arni , Hala Yusminah , Palennari Muhiddin
Published: August 2023

This study aims to examine the influence of adversity intelligence, parents’ attention, and self-efficacy on Biology learning outcomes. This type of study is an expost facto research with a population of all students of grade XI at SMAN in Tana Tidung district, namely SMAN 1 Tana Tidung, SMAN 2 Tana Tidung, and SMAN TU 1 Tana Tidung. The total population was 129 people and based on the sample calculation using the Slovin’s formula, the sample was obtained with 97 people. The sampling technique emplooyed cluster sampling technique. The research instruments used were questionnaires on adversity intelligence, parents’ attention, and self-efficacy as well as documentation of Biology learning outcomes. The data obtained were then analyzed by using descriptive analysis and inferential statistical analysis. The variables of the consisted of independent variables, namely adversity intelligence, parents’ attention, and self-efficacy; whereas, the dependent variable was learning outcomes. Based on the results of inferential analysis and the research results, it is discovered that adversity intelligence has a direct influence on learning outcomes, the parents’ attention has a direct influence on learning outcomes, the self-efficacy has a direct influence on learning outcomes, the adversity intelligence and parents’ attention have an indirect influence through self-efficacy on learning outcomes.
Pengembangan Media Pembelajaran Interaktif Berbasis Articulate Storyline Materi Sistem Reproduksi Manusia Kelas XI SMA Negeri 11 Pangkep
Authors: Muhlis Muhlis
Published: August 2023

This study is a development research that aims to produce a product in the form of interactive learning media based on Articulate Storyline in Human Reproductive System material. This development research refers to the ADDIE development model which consists of five stages, namely Analysis, Design, Development, Implementation, and Evaluation. The subjects of the study were students of grade XI. IPA at SMAN 11 Pangkep. Based on the results of data analysis, it shows that 1) the interactive learning media based on Articulate Storyline on Human Reproductive System material meets the valid criteria with a mean score of 4.54 (very valid), 2) the interactive learning media based on Articulate Storyline material on Human Reproductive System material meets the practical criteria based on the results of the teacher's response by 95.93% (very positive) and the results of the student’s response by 84, 56% (very positive), 3) the interactive learning media based on Articulate Storyline on Human Reproductive System material meets the effective criteria with the percentage of completeness of learning outcomes by 84.62%. Based on the results of the study, it can be concluded that the interactive learning media based on Articulate Storyline material on Human Reproductive System material has met the valid, practical, and effective criteria.
Hubungan Status Sosial Ekonomi dan Sikap Lingkungan Terhadap Perilaku Hidup Bersih dan Sehat (PHBS) di Kecamatan Awangpone Kabupaten Bone
Authors: Rosmawati Rosmawati , Daud Firdaus , Danial Muhammad
Published: August 2023

This research is a correlational quantitative descriptive research that aims to determine the relationship between socio-economic status and environmental attitudes towards clean living behavior (PHBS) in Awangpone District, Bone Regency, the independent variable in this study is Socio-Economic Status, while the dependent variable is clean living behavior and healthy. The population in this study was the people of Awangpone District, Bone Regency. Data collection techniques using a questionnaire. The data analysis technique is descriptive analysis and inferential analysis. Based on the results of inferential data analysis, it was found that there was a positive and significant relationship between environmental attitudes and clean and healthy living behavior at the level of a very strong relationship. Socioeconomic status with clean and healthy living behavior has a positive and significant relationship. Socio-economic status with clean and healthy living behavior is at a very strong relationship level. The biggest effective contribution to the dependent variable (Clean and Healthy Living Behavior) is given by socioeconomic status 34.0% and environmental attitude 51.3%. The total effective contribution is 85.3%, which means that socio-economic status and environmental attitudes together provide an effective contribution of 85.3% to the clean and healthy living behavior of the Awangpone sub-district, Bone district, while 14.7% is influenced by factors not examined.
Pengembangan Buku Ajar Berbantuan Kartu Kwartet Pada Materi Biologi Semester Genap Kelas XI SMA/MA
Authors: Salmawati Salmawati , B Nurhayati , Adnan Adnan
Published: August 2023

Penelitian ini merupakan penelitian pengembangan dengan model ADDIE yang terdiri dari tahapan analyze, design, development, implementation dan evaluation. Sampel penelitian ini adalah peserta didik SMAN 1 Wonomulyo kelas XI MIPA 5. Penelitian ini dilakukan pada bulan Januari - Juni 2021. Buku ajar berbantuan kartu kwartet yang dikembangkan berdasarkan komponen pembelajaran kontekstual yaitu constructivism, questioning, inquiry, learning community, modeling, reflection dan authentic assessment. Buku ajar berbantuan kartu kwartet yang dikembangkan kemudian diuji validitas hingga dinyatakan valid oleh validator lalu diimplementasikan untuk mengetahui observasi keterlaksanaan, respon guru dan respon peserta didik. Hasil penelitian menunjukkan bahwa buku ajar berbantuan kartu kwartet yang dikembangkan memenuhi kriteria kevalidan (4,7), kepraktisan dari hasil lembar observasi keterlaksanaan berada pada kategori terlaksana dengan baik (4.5), respon guru berada pada kategori sangat positif (90%), respon peserta didik berada pada kategori sangat positif  (86%). Dengan demikian dapat disimpulkan bahwa buku ajar berbantuan kartu kwartet yang dikembangkan telah memenuhi kriteria valid dan praktis.
Pengembangan E-Learning Berbasis LMS Computational Thinking Platform Flipped Classroom di SMA Negeri 18 Luwu Utara
Authors: Haryanti Haryanti , Daud Firdaus , Danial Muhammad
Published: August 2023

This research aims to produce LMS-based Biology   e-learning media at SMA Negeri 18 Luwu Utara that is valid, practical and effective, as well as analyze the practicality and effectiveness of the developed e-learning media  .  The research method used is Research & Development (R&D mode used is the Development Model of Robert Maribe Branch (2009) with 5 stages in a cycle, namely ADDIE (Analysis, Design, Development, Evaluation). Sampling uses a simple random sampling technique. The sample of this study is class XII MIPA1 which amounts to 34 students. Kevalidan, Practicality is collected with questionnaire and validation sheets, for effectiveness data is collected with test sheets. Data collection is carried out by testing the validity of products, providing learning outcome tests, collecting student and teacher response data. The data collected was analyzed using quantitative descriptive analysis with the results: 1) The validity of media experts and materials received valid categories from 2 validators; 2) Classical completion of learning outcomes of 88.23%;  3) Teachers and students respond positively to the product, 4) there is a significant link between practicality and effectiveness of the media. Based on the results of the study, the e-learning media  developed is declared valid, practical and effective.
WEBSITE PEMERINTAH SEBAGAI PENERAPAN E-GOVERNMENT
Authors: Wiyanto Siko Dian Sigit , Amelita Thelma , Irwansyah
Published: August 2023

Gelombang digitalisasi baru telah hadir karena kemajuan teknologi internet. E-government muncul sebagai metode utama dari sarana digitalisasi pemerintahan. Salah satu teknologi digital tersebut yakni website sebagai salah satu sarana implementasi e-government. Tujuan dari penelitian ini untuk melihat riset-riset di seluruh dunia terkait penerapan website sebagai penerapan e-government. Penelitian ini menggunakan metode Systematic Literature Review dari 32 jurnal yang terindeks Scopus. Berbagai aspek dalam website e-government yang dibahas pada jurnal ini antara lain e-government, usability, accessibility, user perspective, readability, security, performance, dan fungsi. Usability dan perspektif pengguna menjadi dua hal yang paling banyak dibahas. Pengembangan e-government membutuhkan masukan dari dua sumber, yakni pemerintah sebagai pencipta sistem, dan masyarakat sebagai pengguna sistem. Pemerintah perlu membuat website e-government lebih interaktif lagi dengan pengguna, sedangkan masyarakat perlu didorong untuk berpartisipasi dalam menggunakan dan mengembangkan website e-government. Masih perlu banyak penelitian mengenai website e-government dilakukan khusus implementasinya di Indonesia.
RGB monolithic GaInN-based μLED arrays connected via tunnel junctions
Authors: Saito Tatsunari , Hasegawa Naoki , Imura Keigo , Suehiro Yoshinobu , Takeuchi Tetsuya , Kamiyama Satoshi , Iida Daisuke , Ohkawa Kazuhiro , Iwaya Motoaki
Published: August 2023

We report a 330 ppi monolithic RGB micro light-emitting diodes (μLED) array of blue, green and red GaInN-based LEDs stacked on the same wafer. Considering it is challenging to form ohmic electrodes on the plasma-etched p-type GaN surface, GaInN-based tunnel junctions were used to connect each LED, and anode electrodes for the blue and green LEDs were formed on n-type AlGaN. The fabricated stacked monolithic μLED arrays were tested at room temperature (approximately 26 °C) and DC. Each μLED emitted blue, green and red with peak wavelengths of 486, 514 and 604 nm at a current density of 50 A cm−2.
Diagnosis of bovine genital campilobacteriosis using the cold complement fixation test in Ukrainian farms
Authors: Kalinichenko T. V. , Kutsenko V. A. , Bolotin V. I.
Published: August 2023

The article presents information on the relevance of the bovine genital campylobacteriosis problem and, in particular, its serological diagnosis. The results of determining the activity and specificity of the developed campylobacter antigens in the cold complement fixation test (cCFT) with commercial serum (Virion\Serion), as well as with a panel of homo- and heterologous sera are presented. The results of the analysis of the epizootic situation regarding campylobacteriosis among farm animals in Ukraine for 2019–2020 are shown. Serological monitoring for campylobacteriosis using cCFT was conducted in 22 farms from 9 regions of Ukraine. A total of 727 blood serum samples from cattle and sheep were examined. The overall prevalence of positive animals was 5.7% and 12.9% among cattle and sheep, respectively. These results indicate the circulation of Campylobacter fetus subspecies venerealis and subspecies fetus among cattle and sheep, which can cause significant economic losses in farms
Contemporary aspects of the study of the pharmacodynamics of drugs obtained on the base of organic raw materials
Authors: Kovalenko L. V.
Published: August 2023

The intensive development of animal husbandry and the current international requirements for obtaining ecologically safe, organic foods of agricultural production determine the need to find new means of animal health protection using natural raw materials. In this review, we aim to reveal the directions for obtaining such drugs that can potentially be used in veterinary medicine, as well as the modern principles of studying their pharmacodynamics. The available literature for the past ten years obtained from the electronic databases, such as PubMed, Web of Science, Springer, and Google Scholar has been analyzed. Methodical approaches to obtaining preparations from propolis, various plant raw materials, silkworm pupae, complex products based on metal nanoparticles and organic components have been considered. Along with this, the results of studying the pharmacokinetics of the above mentioned drugs in vitro and in vivo, as well as modern methods of studying their biological effects, including the molecular level using RT-PCR and western blotting, have been highlighted. The issue of studying pharmacodynamics in the context of preclinical studies of biological and pharmacological drugs, taking into account the principles of interspecies extrapolation of dose and its scaling, has also been raised. The presented material can provide new ideas for modern ecological means for animal protection development and determination of their pharmacodynamics characteristics on biological models of different levels
The problem of viral pneumoenteritides in animal husbandry (literature review)
Authors: Perfilova S. I. , Oleshko Oleshko A. Yu. , Gerilovych A. P.
Published: August 2023

The paper summarizes the data on the analysis of epidemiological, serological, and virological studies on pneumoenteritides of cattle in Ukraine and the world. Appropriate programs for the diagnosis, control of viral pneumoenteritides are presented. Sexual, age and breed features of the disease course are described. Analysis of research results allows to determine the main features of the development and course of pneumoenteritides in modern conditions of animal husbandry and to determine the etiologically important at this time associations of pneumoenteritides pathogens. Currently, the issue of viral pneumoenteritides and their associations remains open and requires further epidemiological, serological and virological monitoring. Introduction of vaccination of both the parent herd and young animals at the state level in countries with registered cattle viral pneumoenteritides significantly reduces the incidence in cattle. Vaccination with inactivated and attenuated vaccines is advisable. Since pneumoenteritides viruses are persistent in the environment, it is necessary to regularly disinfect livestock facilities
Exploring the Science of Marma - An Ancient Healing Technique: Marma Therapy
Authors: Mishra Alka , Shrivastava Vandana
Published: August 2023

Marma Science, an extraordinary gem in the vast treasure of Ayurvedic knowledge, represents the science of specific vital places in the body (Marmas), that are the ‘seats of life’ (Prana - the vital life force). As any injury to these parts may lead to severe pain, disability, loss of function, loss of sensation, or death, therefore, they hold an important place in the science of surgery. The ancient scriptures have strictly prohibited causing any injury to the Marmas. However, recent researches have used Marma stimulation for theraputic benefits, with encouraging outcomes. Looking at these mutually conflicting, important applications of Marma Science, the present study was undertaken for its in-depth analysis. Previously, we have explored different aspects of Marma Science in ancient and classical Indian scriptures. In addition, our other study have provided detailed description of the number of Marmas, their location, structures involved, classification, effect of trauma, etc., as per classical texts, as well as correlation with modern science. Previously, we also published its use in Yoga and other ancient Indian traditions, both as a therapeutic technique, as well as for self-defense and inflicting injury on the opponents. The present article explored its application as a therapeutic procedure (Marma Therapy). Different methods of Marma stimulation have been compiled. Therapeutic classification and applications of Marmas have been listed, and several research studies on Marma Therapy have been presented. Several mechanisms for the mode of action of Marma Therapy have been discussed. It is concluded that Marma Science holds significant promise as an effective therapeutic procedure.
NEUROPSYCHOLOGICAL CORRELATES OF PROSOCIAL BEHAVIOUR IN TYPICALLY DEVELOPING CHILDREN
Authors: Gowtham A
Published: August 2023

Prosocial behaviour is the indulgence of an individual in providing voluntary assistance to another individual in need. Empathy, altruism and perspective-taking are closely related concepts. Children and adolescents tend to exhibit varied forms of behaviour as they grow. Neuropsychology is the scientic study of the relationship between the brain and behaviour. Several regions of the brain are found to be responsible for performing prosocial behaviour even in children; some of them are the prefrontal cortex, limbic system, parietal lobule and middle temporal lobe. Psychometric testing, imaging, lesion studies and Stimulation techniques are some of the common methods of understanding the involvement of brain structures. This paper was intended to provide insight into the existing understanding of the brain structures involved by carefully reviewing the literature available and critically evaluating it. Future research directions were also provided.
EFFECTS OF SPINAL ANESTHESIA ON NON-INVASIVELY MEASURED CENTRAL AND PERIPHERAL BLOOD PRESSURE: A PROSPECTIVE OBSERVATIONALBASED CROSS-OVER STUDY.
Authors: Saptaparni. Hazra. , Gourab Paul , Monimala Sen , Binay K Biswas.
Published: August 2023

Vital organ perfusion largely depends on central blood pressure; thus, its maintenance and measurement seem to be important during spinal
anesthesia to avoid morbidity and mortality and to achieve an optimal outcome. Spinal anesthesia brings major hemodynamic changes in the body
with the potential of organ hypoperfusion mainly through its sympatholytic effects. Physicians largely depend on peripheral measurements of
hemodynamics for day-to-day evaluation and medication. This may be because of the difculty in measuring central blood pressure that often
involves single or multiple invasive techniques at a time. Through newer developments in the armamentarium of hemodynamic evaluation
techniques, it is now possible to measure central blood pressure using a non-invasive manner adopting oscillometric methods and larger-sized cuff.
Values obtained with this technique have been validated by different studies in the various clinical scenario. So far, no study has been performed to
nd out the changes in central blood pressure via non-invasive methods following spinal block. In this cross-over study, we have worked to
measure the degree of changes in Central and Peripheral Blood pressure after the introduction of spinal anesthesia among non-obstetric adult
patients scheduled for routine surgical procedures with an aim of more appropriate maintenance of the vital functions.
“PROSPECTIVE COMPARATIVE STUDY ON THE FUNCTIONAL OUTCOME OF ARTHROSCOPIC RECONSTRUCTION OF ANTERIOR CRUCIATE LIGAMENT USING BONE PATELLAR TENDON BONE GRAFT VS HAMSTRING GRAFT”
Authors: Dass Sidhu Shiv , Chand Bansal Mahesh , Meena Devkant , Kumar Lamoria Ravindra , Kumar Harshit
Published: August 2023

Objective: To do detailed comparative study on the functional outcome of bone patellar tendon bone graft and the hamstring tendon graft for reconstruction of ACL and evaluation of results. This was a prospective study com Methods: prising 88 patients who presented with knee instability and/or pain at SMSMC & H,Jaipur from November 2020 to July 2022. They were diagnosed clinically and conrmed by MRI to have ACL tear. Outcome evaluation was done using Lysholm knee score and IKDC. The patients were followed up at 4,8,12 weeks, 6 months and 1 year. Results: Mean post-operative Lysholm score in bone patellar tendon bone group was 88.9 with scores ranging from 81 to 95. Mean post-operative Lysholm score in Hamstring graft group was 88.6 with range from 79 to 95. Arthroscopic ACL Conclusions: reconstruction by either quadrupled STG graft or bone patellar tendon graft gives satisfactory results in short term follow up in terms of activities of daily living, patient satisfaction, and return to near normal daily activity. However, a larger scale study with longer follow up is required to evaluate the long term results.