bluuebunny/crossref_metadata_2025 huggingface dataset:
Características antropométricas y funcionales de individuos físicamente activos
Authors: López Albán Carlos Alejandro , Ramírez Vélez Róbinson , Sánchez Gallardo César Enrique , Marmolejo Liliana Constanza
Published: March 2023

Para conocer su estado de salud y su grado de aptitud física, se hizo una revisión médicodeportiva a 57 mujeres y 60 varones inscritos en el Programa de Actividad Física del Centro para la Investigación en Salud y Rendimiento Humano ZOE, en Cali, Colombia. Con el objeto de aportar datos de referencia, hasta ahora inexistentes en Colombia, se presentan los valores obtenidos. La evaluación antropométrica (peso, talla) sirvió para calcular el Índice de Masa Corporal (IMC). Se practicaron los siguientes estudios físicos: una prueba incremental en cicloergómetro para evaluar el consumo máximo de oxígeno que, junto con los Met, clasificaría la capacidad funcional; pruebas de potencia y flexibilidad. Los resultados fueron como sigue: edad media: 51,4 ± 6,4 años; talla media: 165,0 ± 9,2 cm; peso corporal medio: 72,0 ± 13,4 kg; IMC: 26,6 ± 3,4 kg/m2. La media general del consumo máximo de oxígeno fue 26,5 ± 9,0 mL/kg/min y los Met alcanzados, 7,6 ± 2,6. La potencia anaeróbica media fue 70,6 ± 39,6 kg/seg y la flexibilidad media evaluada con la prueba Sit and Reach fue 23,3 ± 10,7 cm. La información obtenida no se puede extrapolar a la población general pero sirve de punto de partida para otros estudios que caractericen la población colombiana desde los puntos de vista antropométrico y funcional.
Melanoma lentiginoso acral: una variante de melanoma maligno de especial interés en Colombia
Authors: Colmenares Roldán Lina María , Velásquez Lopera Margarita María , Vargas Suaza Gloria Andrea
Published: March 2023

El melanoma lentiginoso acral (MLA) es una variante rápidamente progresiva del melanoma maligno (MM). Constituye el 5-10% de todos los tipos de MM y se presenta con mayor frecuencia en pacientes de raza negra, asiáticos y latinoamericanos. En Colombia el MM se encuentra en aumento, con una incidencia de 3.5/100.000, siendo el MLA una de las variantes más comunes. La edad promedio de presentación es de 58 años, con una tasa de sobrevida menor para las personas de raza negra, asociado a un diagnóstico tardío. EL MLA se localiza en plantas, palmas y región subungueal y en su etiopatología se ha descrito la presencia de mutaciones en genes: 9p21 (p16: 67%), 11q13 (CCND1) (47%), 22q11-q13 (40%) y 5p15 (20%). El diagnóstico de MLA, se ha fundamentado clásicamente en la histopatología. Herramientas de diagnóstico como la dermatoscopia, la evaluación del ganglio centinela y la determinación de alteraciones en las proteínas del ciclo celular contribuyen a la detección precoz del MLA y el MM en general.
Una mutación en el gen PARK2 causa enfermedad de Parkinson juvenil en una extensa familia colombiana
Authors: Pineda Trujillo Nicolas , Dulcey Cepeda Andrés , Arias Pérez William , Moreno Masmela Sonia , Saldarriaga Henao Amanda , Sepúlveda Falla Diego , Bedoya Berrío Gabriel , Lopera Restrepo Francisco , Ruiz-Linares Andrés
Published: March 2023

La enfermedad de Parkinson (EP) es común y se   debe   a degeneración de las neuronas dopaminérgicas en la sustancia nigra y en otras áreas del cerebro. Varios genes y mutaciones han sido implicados en ella y la mayoría de estas últimas han sido identificadas en el gen PARK2. Reportamos la evaluación de este gen PARK2 y de su región flanqueante en una gran familia de origen caucano, al suroccidente de Colombia. Los padres son primos hermanos y cuatro de sus diez hijos resultaron afectados en edad juvenil. La evaluación molecular incluyó tipificación de microsatélites (STR) y la secuencia directa de los exones del gen. Nuestros hallazgos evidenciaron la presencia en condición homocigota de la mutación c.255delA, en el exón 2 de PARK2. Además, se pudo identificar un haplotipo portado por ambos padres y presente en condición homocigota en los hijos afectados. Del mismo modo se observó una alta tasa de recombinantes en la extensión de la región cromosómica analizada. La mutación c.255delA en PARK2 ya había sido reportada previamente en familias tanto de Francia como de España. Nuestros resultados reconfirman la participación del gen PARK2 en la etiología de la enfermedad de Parkinson, en particular de la forma juvenil. Además, considerando que la mutación identificada en la familia que presentamos ya había sido previamente encontrada en poblaciones europeas, es probable que haya llegado a Colombia desde allí. Alternativamente, esta mutación pudo ocurrir de manera recurrente en un ancestro más cercano de la familia estudiada; para verificar ambas posibilidades sería necesario evaluar marcadores flanqueantes de la mutación, en los cromosomas europeos y colombianos portadores  de  la  mutación. Tales  marcadores  pueden  ser STR (como se reporta en este estudio) o alternativamente, SNP.
Respuesta terapéutica a mefloquina, estado nutricional y variantes alélicas del gen CYP3A4 en pacientes con malaria falciparum no complicada; Antioquia (Colombia)
Authors: Guzmán Pérez Valentina , Carmona Fonseca Jaime , Cuesta González Fanny , Maestre Amanda , Burgos Herrera Luis Carlos , Uscátegui Peñuela Rosa Magdalena
Published: March 2023

Introducción: hay poca información sobre las relaciones entre la falla de la terapia antimalárica y algunos factores del hospedero (estado nutricional, fenotipo y genotipo del citocromo CYP450 que metaboliza el medicamento antipalúdico). Objetivo: explorar si la falla terapéutica de la mefloquina dada a pacientes con malaria falciparum no complicada se puede explicar por la influencia del estado nutricional del enfermo y del fenotipo y genotipo de su citocromo CYP3A4. Materiales y métodos: estudio de casos y controles no pareado. Pacientes: hombres y mujeres adultos, de Turbo y El Bagre (Antioquia, Colombia). Resultados: se evaluó la respuesta terapéutica en 46 enfermos; hubo solo tres fallas (6,5%); por la muy baja ocurrencia de falla terapéutica (n = 3/46), los resultados se presentan en forma descriptiva para los 46 pacientes. La relación dextrometorfano/3metoximorfinano fue 0,39 (mediana); 20% fueron metabolizadores lentos. Las concentraciones sanguíneas medianas de mefloquina a las 24 horas (C24h) y al día 14 (Cd14) fueron 1.363 + 397 ng/mL y 978 + 106 ng/mL, respectivamente. Los 46 pacientes presentaron el alelo CYP3A4*2 (silvestre). Conclusión: no se pudo evaluar con profundidad la relación entre la respuesta a la terapia antimalárica, por una parte y, por otra, la actividad del CYP450 y el estado nutricional, pero hubo hallazgos que justifican la evaluación y control de las características del hospedero en estudios posteriores de farmacocinética antimalárica.
Guía de práctica clínica basada en la evidencia para el diagnóstico de disfagia en niños
Authors: Henao Mejía Paula Andrea , Lopera Cañaveral María Victoria , Salazar Blanco Olga Francisca , Medina Piedrahíta Paula Andrea , Morales Múnera Olga Lucía
Published: March 2023

Se presenta una guía basada en la evidencia para el diagnóstico de disfagia en niños. Se llevó a cabo una búsqueda de artículos indexados entre enero de 1996 y diciembre de 2007 en las bases de datos Medline, Lilacs y el registro Cochrane. Se hizo restricción por idioma a publicaciones en inglés y español y, por edad, solo se incluyó a la población pediátrica. Se complementó la exploración con artículos incluidos en la bibliografía de artículos primarios y citados en revisiones no sistemáticas. La estrategia de búsqueda produjo 605 artículos de los cuales se seleccionaron 58. El análisis de la validez de los artículos y el grado de recomendación se hicieron por consenso entre los investigadores. El desarrollo de la guía se basó en el instrumento AGREE (Appraisal of Guidelines Research and Evaluation) y en el modelo GRADE del Colegio Americano de Médicos del Tórax (Grading Strength of Recommendations and Quality of Evidence in Clinical Guidelines).El enfoque diagnóstico del niño con disfagia debe partir de la sospecha clínica. La anamnesis y el examen físico deben preceder a cualquier actividad diagnóstica. Se encontró que en niños con alta sospecha clínica de disfagia debe complementarse la evaluación clínica con la videofluoroscopia (Recomendación 1C), que es el estándar de oro para confirmar la presencia de aspiración o penetración de la vía aérea (Recomendación 1A). El ultrasonido es el método de elección en niños con disfagia asociada a anormalidades de la lengua. (Recomendación 1C). La electromiografía se puede utilizar como una prueba de tamizaje para niños mayores de cinco años con alteración de la musculatura facial (Recomendación 2B). La resonancia magnética nuclear es útil en pacientes con sospecha de lesiones cervicales que alteran la dinámica de la deglución (Recomendación 1C). Se concluye que los estudios diagnósticos disponibles tienen deficiencias metodológicas que no permiten hacer recomendaciones de mayor grado de validez.
Estudio comparativo, cruzado, al azar, para la determinación de la bioequivalencia entre dos formulaciones de oxcarbazepina en tabletas
Authors: Ramírez Correa Gloria Shirley , Restrepo Valencia Piedad , Pérez Guzmán Milena , Pérez Flórez Mauricio , Echeverri García Eduar
Published: March 2023

Dos formulaciones de oxcarbazepina (Trileptal®, Novartis, y Oxcarbazepina®, Tecnoquímicas S. A.), previamente demostradas como equivalentes farmacéuticos, fueron evaluadas en cuanto a bioequivalencia por medio de un estudio aleatorizado, cruzado, en dos períodos, con dosis oral única de 1.200 mg, en 24 hombres adultos voluntarios sanos entre 18-35 años. Se evaluaron los siguientes parámetros farmacocinéticos: Área bajo la curva (AUC), Concentración máxima (Cmáx) y Tiempo para alcanzar la concentración máxima (Tmáx). Hubo un intervalo de lavado de siete días entre los dos períodos. Las concentraciones plasmáticas se evaluaron por HPLC/UV con el método de la adición estándar. No se encontraron diferencias significativas entre las dos preparaciones. Se concluyó que las dos preparaciones son equivalentes farmacéuticos y bioequivalentes y que, en consecuencia, son intercambiables para propósitos terapéuticos.
Securing the Youth Vote: A Comparative Analysis of Digital Persuasion on TikTok Among Political Actors
Authors: Zamora-Medina Rocío , Suminas Andrius , Fahmy Shahira S.
Published: March 2023

In the context of “pop politics” and “politainment,” the irruption of TikTok has changed the landscape of social media and become the fastest-growing application among young people. Based on the peculiarities of the social platform’s affordances and the political personalization approach, we explore the differences between political parties and political leaders in terms of digital persuasion on TikTok in Spain and Poland. This work contributes to the scarce knowledge about the strategic use of TikTok for political purposes. It also attempts to fill the gap in the comparative research into the practical uses of TikTok in different political contexts. The study explores the three classical persuasion appeals—pathos, ethos, and logos—based on a visual, quantitative analysis of N = 372 videos posted on the official TikTok profiles of the main political parties and leaders from January 1st to March 31st, 2022. Differences were found in how political parties and political leaders used TikTok’s affordances as well as in the main rhetorical resource they use to persuade. We noted the use of more rational resources (logos) in the case of political parties and more emotional resources (pathos) for political leaders. Further, the rare presence of the personality in the videos of the political actors (ethos), along with their unusual privatization role, indicate that personalization on TikTok is far from being considered as part of their digital persuasion strategy.
Высшее профессиональное образование в период COVID-19: опыт и рекомендации по улучшению качества дистанционного формата обучения
Authors: Смирнова Г.И. , Турецких С.О.
Published: March 2023

Приведен обзор зарубежного и отечественного педагогического опыта применения дистанционного обучения в высшем профессиональном образовании в условиях пандемии COVID-19, результаты крупномасштабных исследований стран Европы, Азии, Южной и Северной Америки, Африки, Океании. Выявлены достоинства и недостатки (технические, организационные, дидактические и воспитательные) данной формы обучения, обозначенные студентами и преподавателями. Предложены подходы для устранения каждой группы недостатков. Показаны трудности при обучении, испытываемые обучающимися и преподавателями, основные проблемы, их причины, положительный опыт их решения на электронных курсах. Предложены инструменты LMS MOODLE и разработаны рекомендации для решения проблем самоорганизации, самообучения и мотивации обучающихся.

An overview of foreign and domestic pedagogical experience in the use of distance learning in higher professional education in the context of the COVID-19 pandemic, the results of large-scale studies in Europe, Asia, South and North America, Africa, and Oceania are given. The advantages and disadvantages (technical, organizational, didactic and educational) of this form of education, indicated by students and teachers, are revealed. Approaches are proposed to eliminate each group of shortcomings. The learning diffi culties experienced by students and teachers, the main problems, their causes, the positive experience of their solution in electronic courses are shown. LMS MOODLE tools are proposed and recommendations are developed to solve the problems of self-organization, self-learning and motivation of students.
Preventive effects of geraniol in schizophrenia-like symptoms in mice models of psychosis
Authors: Uruaka Christian I. , O. Georgewill Udeme , Georgewill Owunari A.
Published: March 2023

Background: The pathogenesis of schizophrenia has been linked to N-methyl-D-aspartate receptor (NMDAr) inhibition and DAr hyperfunction. Geraniol is a naturally occurring acyclic monoterpene with diverse pharmacological applications. We aimed to assess the effect of geraniol on schizophrenia-like symptoms, vis a vis its modulatory actions on neurochemicals in mice models of psychosis.
Methods: In acute studies, male Swiss mice (n=5/group) were intraperitoneally treated with geraniol (25, 50 and 100 mg/kg), risperidone (0.5 mg/kg) or vehicle (10 ml/kg) prior to ketamine (KET) (10 mg/kg)-induced stereotypy and hyperlocomotion. In the chronic studies, mice (n=7/group) were exposed to 14 days interventions (geraniol or risperidone) following a preventive treatment with KET (20 mg/kg) from days 7-14 consecutively. The effects of treatments (e.g., geraniol or risperidone) alone and on KET-induced schizophrenia-like symptoms were investigated on the last day, 24 hours after treatments. Following that, neurochemical and neurotrophic alterations in the brain (striatum, prefrontal cortex, and hippocampus) tissues were investigated.
Results: Intoxication with KET was associated with schizophrenia-like symptoms as evidenced by stereotypy behavior and hyperlocomotion. KET further induced hyperlocomotion, behavioral despair, and cognitive impairment in the chronic studies. It altered the levels of dopamine, 5-hydroxytrypamine, glutamic acid decarboxylase (GAD), acetylcholinesterase (AChE), and brain-derived neurotrophic factor (BDNF) in brain tissues. However, GER (50 and 100 mg/kg) administration significantly prevented the brain's insults caused by KET.
Conclusions: Altogether, the findings support geraniol's neuroprotective activity while also adding to the body of knowledge that geraniol inhibits schizophrenia-like symptoms via modulation of neurochemical and neurotrophic pathways.
Renal morbidity in type 2 diabetes mellitus patients with and without non-alcoholic fatty liver disease
Authors: Vivek Tanuku , Sharma Shimpa R.
Published: March 2023

Background: Non-alcoholic fatty liver disease (NAFLD) is independently associated with with prevalent as well as incident cardiovascular diseases (CVD), type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD) and Metabolic syndrome (MetS). Awareness of Renal Morbidity and full understanding is work at progress. Hence it was determined to assess the Renal morbidity as measured by eGFR in patients of T2DM with and without NAFLD.
Methods: Patients with T2DM (ICMR 2018 criteria) with proper informed and valid consent and satisfying essential inclusion and exclusion criteria were screened for presence of fatty liver by ultrasound and were divided into two groups; those with NAFLD and without NAFLD. All patients were investigated for renal morbidity in terms of eGFR using MDRD formula.
Result: Diabetic patients with NAFLD had lower eGFR levels compared to diabetics without NAFLD (p<0.05). Patients with diabetes and NAFLD has significantly higher BMI, WHR, duration of diabetes compared to Diabetes patients without NAFLD.
Conclusions: Group of diabetics with NAFLD have to be closely monitoring for serum creatinine levels and BMI is required for early intervention and optimisation of treatment. Elderly patients required more prompt monitoring.
Comparison of hysteroscopic and laparoscopic myomectomy in large type 2 submucous leiomyomas
Authors: Taneja Ashima , Kaur Manpreet , Kaur Amandeep , Arora Mehak , Singh Parampratap , Goyal Mayur
Published: March 2023

Background: Uterine leiomyomas are the most common benign tumors, affecting 30% of women of reproductive age. Submucous myomas are seen in 5.5-10% of all myomas. This study aimed to compare clinical, peri, and post-op outcomes of hysteroscopic and laparoscopic myomectomy in large type 2 submucous myomas.
Methods: A prospective study was performed on 50 patients with large submucous type 2 leiomyomas measuring 3-5cm from October 2020 to August 2022. Patients were randomized into two groups of 25 each. Group A underwent hysteroscopic myomectomy and group B underwent laparoscopic myomectomy.
Results: There was no significant difference in the demographic data of both groups except parity. Perioperative outcomes including bleeding, pain, and hospital stay were significantly higher in the laparoscopy group. None of our patients had air embolism. One patient had blindness in the postoperative period. 2 patients had uterine perforation in the hysteroscopy group. Postoperative pain was higher in the laparoscopy group. Recurrence at 3 months was seen in 2 patients of group A. Asherman syndrome was seen in group A. Single-stage success rate was seen higher in the laparoscopy group.
Conclusions: Laparoscopy and hysteroscopy both are feasible techniques of myomectomy for submucous leiomyomas but for removal of large submucous leiomyomas laparoscopy myomectomy is considered better. For successful removal of large myomas in single-stage hysteroscopy, use of hysteroscopic morcellation should be considered.
Spectacle adherence and barriers towards spectacle wear among primary school going children
Authors: Yadav Rakesh Kumar , Rani Anjali , Chander Ashish
Published: March 2023

Background: The aim of the study was to assess the spectacle adherence and barriers towards spectacle wear among primary school going children in the west UP.
Methods: A cross-sectional, descriptive questionnaire-based study was conducted among the primary school going children in rural area of west UP. Spectacle was provided after the comprehensive eye examination, free of cost to the children those who required. An uninformed visit was planned after 3 months of initial examination to assess the compliance of spectacle wear and non-compliant subjects were questioned about the reasons for not wearing spectacle.
Results: This study consists of total 158 children. In this study, majority of participants 88.61% were myopic having low degree of myopia being more common. Compliance rate towards the spectacle wear was high in males as compared to female children. Compliance rate was significantly varied with the age of participants. Myopic patients show more compliance than the hyperopic patients, it was insignificant while considering the severity of refractive error. The main cause for non-compliance towards spectacle was the cosmetic blemish.
Conclusions: It has been found that the compliance rate towards the spectacle wear was not good enough even after distributing the spectacle free of cost to the children. Various factors including cosmetic blemish, parents and children perception for wearing spectacle and difficulties experienced by the children while wearing glasses were responsible for the non-compliance. The compliance rate can be increased by providing the education and training and Counselling to school teachers, children and their parents regarding the eye health.
Normative study of VO2 max in healthy young adults upon exercise on treadmill and cycle ergometer
Authors: Kothari Ruchi , Srivastava Sujay , Vrindavanam Suryadev , Sharma Snigdha , Bokariya Pradeep
Published: March 2023

Background: As there is a linear relationship between the level of physical activity and health status therefore it is quintessential that an individual’s fitness levels be regularly assessed. Cardio-respiratory fitness (CRF), is quantifiable as VO2 max which is maximal oxygen uptake and is generally considered by exercise physiologists as one of the best indicators of physical fitness. This study aimed to establish baseline normative values of VO2 max in healthy central Indian population upon exercise on treadmill and cycle ergometer as assessed in sports physiology laboratory of a rural medical college.
Methods: A total of 150 healthy young subjects were included in the study within the age group of 17-28 years. The VO2 max score was evaluated by using metabolic module of lab chart software investigated through power lab data acquisition system, AD instruments.
Results: Out of 150 subjects, there were a total of 89 (59.33%) male subjects and 61 (40.66%) female subjects. The mean age of males was 21.20±2.62 years and of females was 20.36±2.69 years. The mean and SD value of VO2 max on treadmill for males was 34.09±4.34 ml/kg/min and for females was 25.09±6.99 ml/kg/min, and on cycle ergometer for males was 32.79±1.85 ml/kg/min and for females was 24.15±5.45 ml/kg/min.
Conclusions: The baseline normative data for CRF parameter, VO2 max was established in the current study to lay the foundation for risk assessment to improve patient management.
Right proximal sub-clavian artery pseudoaneurysm masquerading as right upperzone opacity of lung
Authors: Vasavi Cheguri  , Kadam Mugdha , Medha Jain  , Bhavesh Patel
Published: March 2023

Right proximal subclavian artery pseudoaneurysms are uncommon conditions with a relatively small number of recorded instances to date. Such cases might be challenging to diagnose since the patient may have symptoms that are similar to those of other illnesses, including lung cancer. The diagnosis is aided by imaging methods including contrast-enhanced computed tomography (CECT) chest and computed tomography angiography, as well as a high level of clinical suspicion. We present a rare case of a 23-year-old man with no history of lung disease or trauma, who had a complaints of change in voice, difficulty in swallowing and haemoptysis. Right-sided upper zone homogeneous opacity was seen on the chest X-ray. CECT revealed large, well-defined solid cystic areas that extended up to the posterosuperior aspect of the right upper thoracic region. Aneurysm rupture with active contrast leak. Pulmonary angiography revealed the presence of a pseudoaneurysm in the middle mediastinum on the right side, originating from the right proximal subclavian artery. The patient was operated on, and the right subclavian artery and innominate artery pseudoaneurysm were repaired. If subclavian artery pseudoaneurysms are large, they can cause compression symptoms. For compressive symptoms, open surgical resection and vascular reconstruction are required. In a patient with hemoptysis and opacities on chest imaging, arterial aneurysm should be considered as a differential diagnosis alongside lung mass. Before considering a biopsy from the lesion, further evaluation with CECT should be performed.
Knowledge and attitudes towards dietary patterns and lifestyle during COVID-19 pandemic in Bangladesh: an online based cross-sectional study
Authors: Ielias Uddin  , Rokon M. Alshahria , Sabiha Sultana  , Anika Jahin  , Mursalin  , Ibrahim Khan  , Setu Shraboni Sultana , Mahnaz Rahman  , M. Sahedul Hasan  , Empa Yeasmin  , Rini Asraul Hasibin
Published: March 2023

Background: COVID-19 outbreak being the only pandemic of 21st century, that affected globally, has left us with some realization that elucidate the advancement in science and medicine is not enough to live a healthy life for the generation of modern era, if lifestyle and habitual factors are not controlled or maintained in proper way. In this study we aimed to find out people’s knowledge and attitudes about dietary patterns and lifestyle during COVID-19.
Methods: An online based questionnaire was designed to collect the data based on the age limit of 15 to 60+ years. The survey was focused on both the affected and exposed individuals (n=853). The data was collected under three main sections containing questions about nutritional knowledge, preventive measures adapted by the respondents, lifestyle practices and their concerns.
Results: The outcome of the study reveals, significant association between gender of the study and their food consumption diversity (p=0.026<0.05), participants awareness about COVID-19 depends on their education level. Study also displayed the infection rate, acceptance of vaccination, change of food habit and weight gain tendency depends on the age of the individual, showing statistical significance.
Conclusions: The outcome of the study acquaints that proper balance between knowledge and practice, is the most important attitude, which can build prevention against any new public health threat like COVID-19 outbreak.
Influence of health institution related factors on health seeking behaviors among men suffering from lower urinary tract symptoms attending surgical outpatient clinic at a county referral hospital Meru Kenya
Authors: Muriuki Festus M. , Mbithi Bernard W. , Oluchina Sherry
Published: March 2023

Background: Currently there is an increase in cases of men presenting with lower urinary tract symptoms (LUTS) especially in low resource countries. The purpose of this study was to establish the influence of health institution related factors on health seeking behaviors among men suffering from LUTS attending surgical outpatient clinic at Meru county referral hospital, Kenya.
Methods: Descriptive cross-sectional study design was used. Population involved 120 men suffering from LUTS, 2 physicians and 2 nurses. The study tools used were questionnaires, key informant interview guides and focus group discussion guides. The quantitative data was analyzed using chi-square test and binary logistic regression. Hypothesis testing was done at an alpha level of significance of 0.05 such that any p-values below the alpha were deemed significant.  Qualitative data was analyzed thematically
Results: Health institutional related factors which included adequate personnel 2.57 [95% CI=1.09-6.06, p=0.032], adequate drugs 3.14 [95% CI=1.36-7.23, p=0.007], treated well by the health care workers 2.95 [95% CI=1.18-7.36, p=0.021], short duration time taken to be served in the hospital  2.40 [95% CI=1.12-5.16, p=0.025] and distance to the health facility 2.21 [95% CI=1.01-4.84, p=0.047], significant parameters associated with health seeking behaviors
Conclusions: There was significance influence of health institution related factors on health seeking behaviors among men suffering from LUTS.
Study of musculoskeletal health problem among bankers in Kathmandu valley
Authors: Adhikari Luna Kiran , Chaudhary Pramodh , Sangroula Raj Kumar , Thapaliya Roja , Thapa Janak Kumar
Published: March 2023

Background: Musculoskeletal disorders affect all persons regardless of age and sex and are prevalent across a wide range of industries and jobs. In Asian populations, a high annual prevalence of Work-related Musculoskeletal Disorder in at least one body region is varied from 40% to 95%. The aim of this study was to assess the prevalence and identify the factors contributing to Musculoskeletal disorders.
Methods: Analytical cross-sectional and quantitative method was used. Random sampling was used to select the banks and convenience sampling was used to select the branches of those selected banks and finally, the census technique was used to collect the data from respondents. A structured questionnaire was designed and administered to study participants. Data collected from respondents were entered into Epidata 3.1 and were analysed and expressed using SPSS 26.
Results: The study showed the annual prevalence of Musculoskeletal disorder was 82.5% with the highest single MSDS prevalence of neck pain and the previous one-week prevalence rate was 37.6%. Gender (OR=2.543, 95% CI=1.082-5.974), age group 30-39 (OR=2.430, 95% CI=1.060-5.572, Physical activity (OR=7.379, 95% CI=3.004-18.12), Experience (OR=5.27, 95% CI=2.490-11.185), Repetitive task (OR=22.208, 95% CI= 9.744-50.617), Posture (OR=3.834, 95% CI=1949-7.543), Working hours (OR=2.06, 95% CI=1.070-3.966) were found to be significantly associated with MSDs.
Conclusions: Occupational Health and safety was one of the neglected areas in Banking industry. The concept of occupational safety and health is still new in Nepal.
Influence of gender inequalities in curative and preventive health care use among children between 2 months to 5 years of age and its impact on changing sex ratio of the community
Authors: Agrawal Avyact , Ashokan Vishakha
Published: March 2023

Background: Male preferring mentality of the society has created a discrimination against females in seeking curative and preventive health care and their overall nutritional status.
Methods: Prospective observational study that included all the children between the age of 2 months to 5 years. The data collection started from January 2020 from registers in a monthly fashion till December 2020 and were analysed and categorized based on sex difference in admissions, leave against medical advice, mortality, immunisation, and follow-up.
Results: The basic descriptive statistics shows that there is gross difference in the frequency of admissions in Inpatient (males- 58.33%, females- 41.67%), follow-up care (males- 56.33%, females- 43.67%) and immunization (males-53.06%, females-46.94%). The number of females children who left against medical advice (10.49%) were more than male children (6.45%) and is also statistically significant. In our study a greater number of female deaths (11.02%) occurred compared to males (10.15%) despite of their survival advantage. The number of female children (48.30%) who were admitted in nutritional rehabilitation centre were less compared to the number of males (51.70%). The hospital sex ratio at birth was 114 males per 100 females which is worse than the national average.
Conclusions: Male biased community has put females at risk starting from the time of conception. Gender difference is experienced throughout and in all aspects of social, cultural, healthcare fields and nutritional needs.
An assessment of the psychosocial distress and problems faced by street children living in Kolkata city: a cross-sectional study
Authors: Sandhu Navneet Kaur , Sinha Shubhralok
Published: March 2023

Background: Street children constitute a marginalized group in most societies. These children experience social and behavioural problems resulting from their environmental influences, school and peer interactions, home and family settings, or any combination of these. Keeping in view the prevalence of psychosocial distress among street children, this study was undertaken to assess the levels of psychosocial distress and problems faced by orphan and vulnerable children (OVC) living in Kolkata city.
Methods: This was a cross sectional analytical study. A total of 127 children were interviewed with the help of pre-validated semi-structured questionnaire. GHQ-12 scale was used to measure the symptoms of the psychosocial distress. Bivariate analysis with the help of Chi-square test was done to determine variations in the psychosocial distress experienced by OVC by age, gender, duration of stay on streets, education.
Results: The mean age of the study participants was 15±2 years. About one third of the children showed symptoms of severe psycho-social distress with 30% of children showing signs of intentional self-harm. Age, education and duration of living on the streets were some of the factors that showed significant correlation with the levels of psychosocial distress.
Conclusions: The study concludes that although institutional care and support from NGOs takes care of basic amenities such as shelter, food and education, there is a need to address the psychological needs of the children through teacher sensitization programmes. A well-informed caregiver would be able to address the needs of children under his supervision and care.
Knowledge, awareness and practices towards exclusive breastfeeding among lactating mothers in Kashmir, North India: a hospital based cross sectional study
Authors: Nabi Sahila , Zahoor Nazia , Muzamil Furqanah
Published: March 2023

Background: Addressing good breastfeeding practices in lactating mothers is important as it helps in bringing about a positive change in the behaviour, attitude, and practice with appropriate health education. Hence, this study was conducted to determine the knowledge, awareness and practices of lactating mothers regarding breastfeeding and identify the factors associated with it.
Methods: We conducted this hospital based cross sectional study among 349 lactating mothers at pediatric outpatient department of a tertiary care centre in Kashmir, North India between July to October 2022. Details regarding the socio-demographic characteristics and awareness/knowledge about the breastfeeding were collected using pretested semi-structured questionnaire. Data was collected through face-to-face interview.
Results: Majority of the participants 305 (87.4%) knew the meaning of exclusive breastfeeding and it is important for both mother and child. About (68.8%) had moderate knowledge about breastfeeding. Chi square test showed a significant association between level of knowledge and age, education and family type where p value was 0.000.
Conclusions: Our findings showed that the practice towards exclusive breast-feeding was low. Thus, it is important to provide prenatal education to mothers and fathers on breast-feeding. We also recommend strengthening the public health education campaigns to promote breast-feeding.
Hepatitis B vaccination status and knowledge, attitude, and practice of hepatitis B among medical students at a medical college in central India
Authors: Subodh R. Thote  , Gajanan C. Soyam  , Dhakate Manish A.
Published: March 2023

Background: Hepatitis B virus (HBV) infection imposes a major public health problem with an increased risk of occupational exposure among unvaccinated health care workers (HCWs). This study was conducted to determine the Hepatitis B vaccination status, along with the knowledge, attitude, and practice regarding Hepatitis B, among medical students at a medical college in a central India.
Methods: A cross-sectional study was conducted from February 2022 to July 2022. A total of 477 students of health care professions were included into the study using a whole sampling technique. Data were collected using self-administered structured questionnaire and analyzed by using statistical package for the social sciences (SPSS) version 26.
Results: Response rate was 91.61% (437). Majority of the students (>80%) had an adequate knowledge on risk factors for HBV, its mode of transmissions, and preventions. About 192 of 437 (43.9%) participants had positive attitude towards following infection control guidelines, and 310 (70.9%) respondents believe that all HCWs should take HBV vaccine. However, only 11.2% students had completed the three doses schedule of HBV vaccination. Whereas, a significant number of students, 142 (32.5%), had been exposed to blood/body fluid via needle stick injury at least once since they started their training in the health facility.
Conclusions: Study found that trainees in health profession are at a very high risk of contracting HBV infection during their training due to the low HBV vaccine uptake rate and high rate of accidental exposure to blood. We recommend that all students in the health profession should be vaccinated prior to their entry into professional practices.
COVID-19 and the Indian healthcare scenario
Authors: Barman Paramita
Published: March 2023

Background: The Indian economy and health system has been shaken to the core by the sudden strike of the COVID-19 pandemic. The already fragile and underequipped public health system reeled under the pressure of escalating cases of infection and demand for hospitalization of critical and emergency cases of COVID. Although the private healthcare sector worked in sync with the public counterpart and provided adequate support for case management, the former is not expected to play the primary role when it comes to a public health crisis like COVID-19. The study attempts to explore the pattern of utilization of the existing health system by Indian households in the event of general illness, which is expected to throw some light on the mechanism for devising an optimal public-private mix for management of COVID or similar public health threats in future.
Methods: The study was exploratory and based on secondary data. It employs unit level data from NFHS-4 (2015-16) besides published reports and documents.
Results: Health insurance coverage is low among households belonging to the lowest wealth quintile. Inequalities in access to quality health care coupled with spiraling health costs due to COVID and falling incomes continue to push such vulnerable households into poverty and debt.
Conclusions: Public expenditure on health should be increased with a shift in focus from curative to preventive care.
Alleviating the impact of the geohelminthiases in the COVID-19 crisis
Authors: Falah Pilar Menara , Nurdian Yudha
Published: March 2023

Alleviating geohelminthiases impact during 2019 coronavirus disease (COVID-19) is complicated. Various efforts have been made to reduce them. Chemoprevention such as annual or biennial mass preventive drugs (MPD) with albendazole or mebendazole as a single dose for at-risk populations, including preschool children, school-age children, adolescent girls, childbearing age women, and pregnant women, is the form of short-term action. Long-term actions are providing clean water, improving sanitation and toilets, banning on the usage of stool as fertilizer, and counseling on a clean and healthy lifestyle (CHL) accompanied by implementing community based total sanitation (CBTS). The challenges of them are inconstancy in observing the programs, chemoprevention coverage growth in at-risk groups, drug resistance manifestation, and weak diagnostic methods.
O fazer profissional no cotidiano: vivências de práticas educativas na prevenção de intercorrências mamárias que incentivam a promoção do aleitamento materno
Authors: Rodrigues Valéria de Oliveira , Alves da Silva Bruna Christi , Jesus Alcione da Camara de , Cruz Adison Santana , Pereira Lima Sáskya Phlísia , Gomes Daiene Rosa , Mattos Mussio Pirajá
Published: March 2023

Objetivo: o presente estudo tem por objetivo relatar as vivências dos acadêmicos do curso de Enfermagem, acerca de atividades de educação em saúde na prevenção das intercorrências mamárias e na promoção do aleitamento materno, vinculada a Liga Interdisciplinar de Saúde da Criança da Universidade Federal do Oeste da Bahia. Métodos: trata-se de um estudo descritivo do tipo relato de experiência com o desenvolvimento de atividades educativas, através de orientações sobre a conscientização relacionada à prevenção das intercorrências mamárias, por meio da exposição de cartaz, banners, moldes em formas de mamas e entrega de folders. Resultados: durante a realização da atividade notou-se que o processo de educação em saúde abrangeu quatro aspectos fundamentais como a comunicação, informação, educação e escuta qualificada. Também foi possível observar o grande interesse e interação da população acerca da intervenção, os quais expressavam suas experiências e conhecimentos empíricos. Assim, foram orientadas sobre as prevenções a serem tomadas diante das intercorrências mamárias e o incentivo a promoção do aleitamento materno. Conclusões: dessa forma, foi possível perceber que a atividade de educação em saúde contribuiu para a prevenção, proteção e promoção da saúde, havendo uma junção dos conhecimentos prévios da população com os conhecimentos técnico-científicos, permitindo um ambiente transformador de informações, que contribuíram para oferta de qualidade de vida para o binômio mãe-filho e para formação profissional dos acadêmicos.
Silencing circCAMSAP1 suppresses malignant behavior of endometrial cancer by targeting microRNA-370-3p/MAPK1
Authors: Zhang Hai Feng , Cao Cheng Cheng , Nie Cui Cui , Zhang Ting
Published: March 2023

The study was conducted to figure out the function and mechanism of circular RNA circCAMSAP1 in repressing malignant behavior of endometrial carcinoma (EC) by targeting microRNA (miR)-370-3p /MAPK1. Tumor tissues and normal adjacent tissues of EC patients were harvested, and circCAMSAP1 and MAPK1 were elevated but miR-370-3p was reduced in tissues and cells of EC patients. Functional test results clarified transfection of si-circCAMSAP1 or miR-370-3p-mimic refrained cancer cell proliferation, migration and invasion, but motivated cancer cell apoptosis. Meanwhile, the amount of E-cadherin elevated and the amount of N-cadherin elevated or reduced. After co-transfection with si-circCAMSAP1 and miR-370-3p-inhibitor, miR-370-3p-inhibitor blocked si-circCAMSAP1’s therapeutic impact. Furthermore, after co-transfection of pcDNA-circCAMSAP1 and si-MAPK1, si-MAPK1 turned around the malignant effect of pcDNA-circCAMSAP1. It was testified that miR-370-3p was circCAMSAP1’s target, and inversely controlled via circCAMSAP1. Meanwhile, enhancing miR-370-3p led to repressive MAPK1, which was recognized as miR-370-3p’s downstream target. All in all, the results of this study convey silencing circCAMSAP1 refrains the malignant behavior of EC by controlling miR-370-3p /MAPK1 axis.
Digital Leadership and Maturity as a Key to Successful Digital Transformation: Country Case Study of Croatia
Authors: Kokot Karolina , Đunđek Kokotec Ivana , Klačmer Čalopa Marina
Published: March 2023

Organizations are facing a disrupted environment, which results in a need for managers who can quickly respond to volatile conditions. Such conditions lead to changes in traditional leadership and the construction of new leadership recognized by contemporary literature as digital leadership (DL). The main objective of this research paper is to examine the levels of DL and digital maturity (DM) in small and medium-sized Croatian companies in the context of digital transformation (DT). The research sample included 156 companies, and the results indicated relatively high levels of DL; indeed, nearly four companies achieved the highest level of DM. The results indicated a negative correlation between the level of DL and DM. Gender was shown to have an impact on the level of DL, while it was not indicated that gender has an impact on the level of DM.
Flamenco Dance and Visitor Loyalty: The Case of Cordoba-Spain
Authors: Pérez-González María-Dolores , Hernández-Rojas Ricardo , Jimber-del-Río Juan-Antonio , Vergara-Romero Arnaldo
Published: March 2023

Flamenco dance is internationally recognized in the world. Its uniqueness based on ancestral culture and tradition is a current projection of immemorial dances. Currently, it is performed in schools, conservatories, and the so-called flamenco shows in some destinations, where visitors can enjoy it. Therefore, it is essential to deepen its management and study.
This investigation aims to analyze the flamenco dance show from the perspective of the general visitor capability. To determine loyalty, the study focuses on tourist fidelity based on the show's perceived value, quality, and satisfaction. The fieldwork has been carried out in Córdoba (Spain). There are few studies on flamenco dance from the attending visitor's perspective, this being a novelty and a contribution to research. The methodology is founded on a partial least squares (PLS) structural equation model. A structured questionnaire has been used to meet the objective, and the conclusions acquired corroborate that the agreement and quality of flamenco dance positively influence tourist loyalty and, therefore, recommend returning to the destination and repeating the visit.
The Effect of Total Quality Service with E-Bekal on Customer Satisfaction
Authors: Zamroni Zamroni , Baharun Hasan , Wahid Abd Hamid , Muali Chusnul , Fitriyah Sumarhum Shafa Maliya
Published: March 2023

This study aims to examine the public's perception of the services quality provided by the Nurul Jadid Islamic Boarding School through the application of E-Bekal as an Islamic boarding school innovation in the face of the Revolution 4.0 era. The quantitative correlational approach was applied in this investigation. The data was gathered through observation and the distribution of questionnaires. A total of 125 people were surveyed, including guardians and alums. Somers'D correlation analysis was used to do the data analysis. The findings show that total quality service has a joint influence on customer expectations and satisfaction with the quality of services provided by Nurul Jadid Islamic Boarding School through the application of the E-Bekal santri service, with a significance value of 0.05 and has a positive correlation with the coefficient value of 0.863 on the customer expectation variable, and 0.540 on the satisfaction variable. Consumer expectations and satisfaction are both influenced by total quality service.
Active Involvement in Home-School Collaboration and its Impact on Student Motivation – the Slovenian Experience
Authors: Grafenauer Ekart Živa , Vršnik Perše Tina
Published: March 2023

Research suggests that home-school collaboration is successful when it involves all elements of the parent-teacher-student triangle. However, Slovenian schools do not practice three-way conferences, since students, who are a crucial part of the collaboration, are often excluded from the process. This paper presents the results of a study conducted in two classes of Year 4 (9 Years old students) at a Slovenian primary school (experimental and control group). The study focused on identifying the effect of involving students in parent-teacher collaboration through three-way conferences. The findings revealed that these conferences contributed to the improved level of student motivation to do schoolwork.
The Perceptions of Prospective Digital Transformation Adopters: An Extended Diffusion of Innovations Theory
Authors: Huong Pham Thi , Duc Nguyen Lam
Published: March 2023

This study investigated the effects of factors that influence users' perceptions to adopt digital transformation. Eight hypotheses were proposed and tested employing the Structural Equation Modeling. 248 government personnel, instructors, and students were recruited to answer the questionnaires through Google Form. The experimental results indicated that facilitating conditions, policy, social influence, and knowledge all had a positive and significant impact on digital transformation adoption. Meanwhile, policy was found to have a positive effect on social influence. In turn, social influence positively affected knowledge. In addition, awareness was verified to be a reliable predictor of knowledge. The notable exception was that the awareness factor was shown to have no effect on digital transformation adoption. Thus, traditional reaching to citizens via television, news, broadcast needed to re-examined. Overall, the model accounts for 52.5 percentage of the variation in the data. Four recommendations were proposed for practitioners, and limitations were roughly discussed. Future study is needed to re-examine the unexpected effect of awareness on digital transformation adoption.