bluuebunny/crossref_metadata_2025 huggingface dataset:
Enrichment of Scleroderma Vascular Disease–Associated Autoantigens in Endothelial Lineage Cells
Authors: McMahan Zsuzsanna H. , Cottrell Tricia R. , Wigley Fredrick M. , Antiochos Brendan , Zambidis Elias T. , Soon Park Tea , Halushka Marc K. , Gutierrez‐Alamillo Laura , Cimbro Raffaello , Rosen Antony , Casciola‐Rosen Livia
Published: May 2016

Objective

Scleroderma patients with autoantibodies to CENPs and/or interferon‐inducible protein 16 (IFI‐16) are at increased risk of severe vascular complications. This study was undertaken to determine whether these autoantigens are enriched in cells of the vasculature.

Methods

Successive stages of embryoid bodies (EBs) as well as vascular progenitors were used to evaluate the expression of scleroderma autoantigens IFI‐16 and CENP by immunoblotting. CD31 was included to mark early blood vessels. IFI‐16 and CD31 expression were defined in paraffin‐embedded skin sections from scleroderma patients and from healthy controls. IFI‐16 expression was determined by flow cytometric analysis in circulating endothelial cells (CECs) and circulating hematopoietic progenitor cells.

Results

Expression of CENP‐A, IFI‐16, and CD31 was enriched in EBs on days 10 and 12 of differentiation, and particularly in cultures enriched in vascular progenitors (IFI‐16, CD31, and CENPs A and B). This pattern was distinct from that of comparator autoantigens. Immunohistochemical staining of paraffin‐embedded skin sections showed enrichment of IFI‐16 in CD31‐positive vascular endothelial cells in biopsy specimens from scleroderma patients and normal controls. Flow cytometric analysis revealed IFI‐16 expression in circulating hematopoietic progenitor cells but minimal expression in CECs.

Conclusion

Our findings indicate that expression of the scleroderma autoantigens IFI‐16 and CENPs, which are associated with severe vascular disease, is increased in vascular progenitors and mature endothelial cells. High level, lineage‐enriched expression of autoantigens may explain the striking association between clinical phenotypes and the immune targeting of specific autoantigens.
Bcl‐2 as a Therapeutic Target in Human Tubulointerstitial Inflammation
Authors: Ko Kichul , Wang Jianing , Perper Stuart , Jiang Yulei , Yanez Denisse , Kaverina Natalya , Ai Junting , Liarski Vladimir M. , Chang Anthony , Peng Yahui , Lan Li , Westmoreland Susan , Olson Lisa , Giger Maryellen L. , Chun Wang Li , Clark Marcus R.
Published: May 2016

Objective

In lupus nephritis, tubulointerstitial inflammation (TII) is associated with in situ adaptive immune cell networks that amplify local tissue damage. Since conventional therapy appears ineffective for severe TII, and these patients often progress to renal failure, understanding in situ mechanisms might reveal new therapeutic targets. This study was undertaken to assess whether dysregulated apoptotic regulators maintain local adaptive immunity and drive inflammation in TII.

Methods

This study utilized novel computational approaches that, when applied to multicolor confocal images, quantified apoptotic regulator protein expression in selected lymphocyte subsets. This approach was validated using laser‐capture microdissection (LCM) coupled to quantitative polymerase chain reaction (qPCR). Furthermore, the consequences of dysregulated apoptotic mediator expression were explored in a murine model of lupus nephritis.

Results

Analyses of renal biopsy tissue from patients with lupus nephritis and those with mixed cellular renal allograft rejection revealed that the B cell lymphoma 2 protein (Bcl‐2) was frequently expressed in infiltrating lymphocytes, whereas expression of myeloid cell leukemia 1 was low. In contrast, the reciprocal pattern of expression was observed in tonsil germinal centers. These results were consistent with RNA expression data obtained using LCM and qPCR. Bcl‐2 was also highly expressed in tubulointerstitial infiltrates in (NZB × NZW)F1 (NZB/NZW) mice. Furthermore, treatment of NZB/NZW mice with ABT‐199, a selective oral inhibitor of Bcl‐2, prolonged survival and prevented proteinuria and development of TII in a lupus prevention model. Interestingly, glomerular immune complexes were partially ameliorated by ABT‐199 treatment, and serum anti–double‐stranded DNA antibody titers were unaffected.

Conclusion

These data demonstrate that Bcl‐2 is an attractive therapeutic target in patients with lupus nephritis who manifest TII.
An approximate likelihood estimator for the prevalence of infections in vectors using pools of varying sizes
Authors: Santos James D. , Dorgam Diana
Published: May 2016

There are several arthropods that can transmit disease to humans. To make inferences about the rate of infection of these arthropods, it is common to collect a large sample of vectors, divide them into groups (called pools), and apply a test to detect infection. This paper presents an approximate likelihood point estimator to rate of infection for pools of different sizes, when the variability of these sizes is small and the infection rate is low. The performance of this estimator was evaluated in four simulated scenarios, created from real experiments selected in the literature. The new estimator performed well in three of these scenarios. As expected, the new estimator performed poorly in the scenario with great variability in the size of the pools for some values of the parameter space.
Accelerated homology‐directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment
Authors: Lee Jae Seong , Grav Lise Marie , Pedersen Lasse Ebdrup , Lee Gyun Min , Kildegaard Helene Faustrup
Published: May 2016

Targeted gene integration into site‐specific loci can be achieved in Chinese hamster ovary (CHO) cells via CRISPR/Cas9 genome editing technology and the homology‐directed repair (HDR) pathway. The low efficiency of HDR often requires antibiotic selection, which limits targeted integration of multiple genes at multiple sites. To improve HDR‐mediated targeted integration, while avoiding the use of selection markers, chemical treatment for increased HDR, and fluorescent enrichment of genome‐edited cells was assessed in CHO cells. Chemical treatment did not improve HDR‐mediated targeted integration. In contrast, fluorescent markers in Cas9 and donor constructs enable FACS enrichment, resulting in a threefold increase in the number of cells with HDR‐mediated genome editing. Combined with this enrichment method, large transgenes encoding model proteins (including an antibody) were successfully targeted integrated. This approach provides a simple and fast strategy for targeted generation of stable CHO production cell lines in a rational way. Biotechnol. Bioeng. 2016;113: 2518–2523. © 2016 Wiley Periodicals, Inc.
Construction of plasmids with tunable copy numbers in Saccharomyces cerevisiae and their applications in pathway optimization and multiplex genome integration
Authors: Lian Jiazhang , Jin Run , Zhao Huimin
Published: May 2016

The CEN/ARS‐based low‐copy plasmids and 2 μ‐based high‐copy plasmids have been broadly used for both fundamental studies and practical applications in Saccharomyces cerevisiae. However, the relative low copy numbers and narrow dynamic range limit their applications in many cases. In this study, the expression level of the selection marker proteins was engineered to increase the plasmid copy numbers. A series of plasmids with step‐wise increased copy numbers were constructed. The copy number of the plasmids with engineered dominant markers (5–100 copies per cell) showed a positive correlation with the concentration of antibiotics supplemented to the growth media. Based on this finding, we developed a simple yet highly efficient strategy, named Pathway Optimization by Tuning Antibiotic Concentrations (POTAC) to rapidly balance the flux of multi‐gene pathways at the DNA level in S. cerevisiae. As proof of concept, POTAC was used to optimize the lycopene and n‐butanol biosynthetic pathways, increasing the production of lycopene and n‐butanol by 10‐ and 100‐fold, respectively. Additionally, multiplex genome integration with controllable copy numbers was attempted by combining the engineered dominant markers with the CRISPR/Cas9 system. Biotechnol. Bioeng. 2016;113: 2462–2473. © 2016 Wiley Periodicals, Inc.
Mold‐casted non‐degradable, islet macro‐encapsulating hydrogel devices for restoration of normoglycemia in diabetic mice
Authors: Rios Peter Daniel , Zhang Xiaomin , Luo Xunrong , Shea Lonnie D.
Published: May 2016

Islet transplantation is a potential cure for diabetic patients, however this procedure is not widely adopted due to the high rate of graft failure. Islet encapsulation within hydrogels is employed to provide a three‐dimensional microenvironment conducive to survival of transplanted islets to extend graft function. Herein, we present a novel macroencapsulation device, composed of PEG hydrogel, that combines encapsulation with lithography techniques to generate polydimethylsiloxane (PDMS) molds. PEG solutions are mixed with islets, which are then cast into PDMS molds for subsequent crosslinking. The molds can also be employed to provide complex architectures, such as microchannels that may allow vascular ingrowth through pre‐defined regions of the hydrogel. PDMS molds allowed for the formation of stable gels with encapsulation of islets, and in complex architectures. Hydrogel devices with a thickness of 600 μm containing 500 islets promoted normoglycemia within 12 days following transplantation into the epididymal fat pad, which was sustained over the two‐month period of study until removal of the device. The inclusion of microchannels, which had a similar minimum distance between islets and the hydrogel surface, similarly promoted normoglycemia. A glucose challenge test indicated hydrogel devices achieved normoglycemia 90 min post‐dextrose injections, similar to control mice with native pancreata. Histochemical staining revealed that transplanted islets, identified as insulin positive, were viable and isolated from host tissue at 8 weeks post‐transplantation, yet devices with microchannels had tissue and vascular ingrowth within the channels. Taken together, these results demonstrate a system for creating non‐degradable hydrogels with complex geometries for encapsulating islets capable of restoring normoglycemia, which may expand islet transplantation as a treatment option for diabetic patients. Biotechnol. Bioeng. 2016;113: 2485–2495. © 2016 Wiley Periodicals, Inc.
Parental bonding and neuropsychological performance are associated with episodic simulation of future events in trauma‐exposed patients with major depressive disorder
Authors: Parlar Melissa , Lee Alex , Haqqee Zeeshan , Rhooms Latisha , Lanius Ruth A. , McKinnon Margaret C.
Published: May 2016

Introduction

Major depressive disorder (MDD) and trauma‐related disorders are associated with deficits in remembering the past and imagining the future (i.e., episodic simulation). We examined parental bonding and neuropsychological performance in relation to episodic simulation in trauma‐exposed patients with recurrent MDD.

Methods

Trauma‐exposed patients with MDD (n = 21) and matched controls (n = 20) completed a future‐oriented Autobiographical Interview, the Parental Bonding Instrument, and a standardized neuropsychological battery.

Results

Patients with major depressive disorder generated fewer episodic details for future neutral events compared to controls. Although higher reported levels of maternal care were associated with increased specificity of negative future events among the patient group, higher maternal overprotection was related to decreased specificity of negative and positive future events. Higher levels of performance on measures of intelligence, verbal memory, executive functioning, and sustained attention were associated with increased specificity of future events.

Conclusions

Maternal relations during childhood and neuropsychological performance are related to the specificity of episodic simulation in adult patients with MDD. Childhood experience continues to influence memory performance into adulthood.
Expanding an Efficient, Electrically Driven and CNT‐Tagged P450 System into the Third Dimension: A Nanowired CNT‐Containing and Enzyme‐Stabilising 3 D Sol–Gel Electrode
Authors: Llaudet Enrique C. , Darimont Dominique , Samba Ramona , Matiychyn Ilona , Stelzle Martin , Weissenborn Martin J. , Hauer Bernhard
Published: May 2016

Although electrochemically catalysed P450 reactions have been described, their efficiency and applicability remained limited. This is mostly due to low enzyme activity, laborious protein immobilisation and the small electrode surface. We established a novel protein immobilisation method for a determined orientation and electrical wiring of the enzyme without post‐expression modification. By genetic introduction of an anchor‐peptide our method is applicable for screening medium to large mutant libraries and detection by an electrode system. The system was expanded by using wired carbon nanotubes within a sol‐gel matrix to create a three dimensional electrode.
Ligand‐Mediated G‐Quadruplex Induction in a Double‐Stranded DNA Context by Cyclic Imidazole/Lysine Polyamide
Authors: Asamitsu Sefan , Li Yue , Bando Toshikazu , Sugiyama Hiroshi
Published: May 2016

G‐quadruplex (G4) DNA is often observed as a DNA secondary structure in guanine‐rich sequences, and is thought to be relevant to pharmacological and biological events. Therefore, G4 ligands have attracted great attention as potential anticancer therapies or in molecular probe applications. Here, we designed cyclic imidazole/lysine polyamide (cIKP) as a new class of G4 ligand. It was readily synthesized without time‐consuming column chromatography. cIKP selectively recognized particular G4 structures with low nanomolar affinity. Moreover, cIKP exhibited the ability to induce G4 formation of the promoter of G4‐containing DNA in the context of stable double‐stranded DNA (dsDNA) under molecular crowding conditions. This cIKP might be applicable as a molecular probe for the detection of potential G4‐forming sequences in dsDNA.
Mechanical thrombectomy using the Solitaire stent in a left main coronary artery: A novel approach to coronary thrombus retrieval
Authors: Uribe Carlos E. , Zuñiga Mauricio , Madrid Camilo
Published: May 2016

The Solitaire stent is a self‐expanding nitinol, fully retrievable stent that was originally designed for applications in cerebral circulation. Expanded indications for its use in mechanical embolectomy during acute ischemic stroke have proven safe and effective. Herein, we describe a novel use of this stent to perform a mechanical thrombectomy of a large left main coronary artery thrombus. © 2016 Wiley Periodicals, Inc.
Polyaniline Nanorods Grown on Hollow Carbon Fibers as High‐Performance Supercapacitor Electrodes
Authors: Gao Shuangyan , He Shuyue , Zang Peiyu , Dang Liqin , Shi Feng , Xu Hua , Liu Zonghuai , Lei Zhibin
Published: May 2016

Hollow carbon fibers (aCFs) with a high specific surface area are applied as conductive scaffolds for polyaniline (PANi) growth. aCFs oxidized by HNO3 treatment have more surface negative charges, which interact with protonated aniline molecules in acidic media. The subsequent chemical oxidative polymerization assisted by (NH4)2S2O8 yields aCF–PANi composites with PANi nanorod arrays strongly coupled on both the external and internal surfaces of the aCFs. Serving as binder‐free supercapacitor electrode, the aCF–PANi composite with 31 wt % PANi exhibits a specific capacitance of 364 F g−1, and retains 70 % of this value at 20 A g−1. More interestingly, it exhibits excellent cycling stability with 92.5 % capacitance retention, and outstanding reversibility with 98.6 % coulombic efficiency, even after 5000 continuous cycles; this performance is far superior to that of both aCF and PANi electrodes. The strongly coupled PANi arrays on the aCF surface greatly reduce the interface resistance, thus facilitating both ion and electron transport for enhanced capacitive performance.
The Electric Double Layer in an Ionic Liquid Incorporated with Water Molecules: Atomic Force Microscopy Force Curve Study
Authors: Zhong Yunxin , Yan Jiawei , Li Miangang , Chen Li , Mao Bingwei
Published: May 2016

Electrochemical techniques and atomic force microscopy based force curve measurements under potential control are combined to investigate the effect of small amounts of water on the structure of the electric double layer of an Au(111)/1‐butyl‐1‐methylpyrrolidinium bis(trifluoromethylsulfonyl)amide (BMPTFSA) interface. Three to five layering structures, including two charged layers, are observed at the Au(111)/BMPTFSA interface at potentials more negative than the point of zero charge. With an increase in the water concentration, the stiffness values for both the first and second layers decrease, which demonstrates that more water molecules adsorb on the Au(111) surface or interact with the ionic liquid, and thus weaken the interactions between cations, anions, and the electrode surface and lower the stability of the layering structures. The thicknesses of the charged interior layers (the first and second layers in this system) increase with an increase in the water concentration and the thicknesses of neutral exterior layers (the next one to three layers in this system) remain almost unchanged. The structure of the first layer of the interface varies dramatically with the change in the water concentration.
Towards Uniform Iodine Catalysis: Intramolecular C−H Amination of Arenes under Visible Light
Authors: Martínez Claudio , Bosnidou Alexandra E. , Allmendinger Simon , Muñiz Kilian
Published: May 2016

A photochemical catalytic amination of arenes is presented. The reaction proceeds under benign iodine catalysis in the presence of visible light as the initiator and provides access to a range of differently substituted arylamines. A total of 29 examples demonstrate the broad applicability of this mild oxidation method. The scope of the reaction could further be expanded to silyl‐tethered derivatives, which undergo intramolecular amination upon formation of seven‐membered heterocycles. Cleavage of the silicon tether provides access to the corresponding 3‐substituted anilines.
ChemInform Abstract: ELECTRON‐TRANSFER QUENCHING OF THE LUMINESCENCE OF RUTHENIUM AND OSMIUM POLYPYRIDINE COMPLEXES BY COBALT(III) COMPLEXES
Authors: SANDRINI D. , GANDOLFI M. T. , MAESTRI M. , BOLLETTA F. , BALZANI V.
Published: May 2016

Die Lumineszenzlöschung der Komplexe (I) und (II) durch 17 Co(III)‐Komplexe wird in wäßriger Lösung untersucht.
ChemInform Abstract: CIRCULARLY POLARIZED LUMINESCENCE STUDIES OF THE ADDUCTS FORMED WITH EUROPIUM(III) β‐DIKETONE COMPLEXES AND (‐)‐SPARTEINE
Authors: BRITTAIN H. G. , FINEMAN R. I.
Published: May 2016

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ChemInform Abstract: CONFORMATIONAL ANALYSIS OF ORGANIC CARBONYL COMPOUNDS. PART 4. A PROTON AND CARBON‐13 NUCLEAR MAGNETIC RESONANCE STUDY OF FORMYL AND ACETYL DERIVATIVES OF BENZO(B)FURAN
Authors: BENASSI R. , FOLLI U, , IAROSSI D. , SCHENETTI L. , TADDEI F.
Published: May 2016

Im Gegensatz zu den entsprechenden Benzo[b]thiophenen treten die 2‐ und 7‐Carbonylverbindun‐ gen der Benzofuranreihe in unpolaren Lösungsmitteln bevorzugt als E‐Konformere auf.
ChemInform Abstract: ORGANIC AZIDES. PART 4. SYNTHESIS OF AZIDOBUTADIENES
Authors: PRIEBE H.
Published: May 2016

Aus dem Dibromid (Ia) bzw. dem Bromid (III) werden durch Substitution mit Azid und anschlie‐ βende lß‐Umlagerung das Diazidobutadien (II) bzw. das Azidobutadien (IV) erhalten.
ChemInform Abstract: THE REACTION OF TERTIARY AMINES WITH ELECTROPHILIC REAGENTS. I. THE REACTION OF TERTIARY AMINES WITH ARENESULFONYL CHLORIDES
Authors: SHIRAISHI S. , TAKAYAMA T.
Published: May 2016

Tertiäre Amine wie 1‐Azabicyclooctan (Ia), Diazabicyclooctan (DABCO) (Ib) oder 4‐Methylpyrrolidin (V) reagieren mit Sulfonylchloriden (II) unter Öffnung einer C‐N‐Bindung und Bildung von Sulfonamiden.
ChemInform Abstract: SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF DANTROLENE AND SODIUM DANTROLENE
Authors: OLEINIK A. F. , ANDREEVA N. I. , SYUBAEV R. D. , GOLOVINA S. M. , VOZYAKOVA T. I.
Published: May 2016

Der Aldehyd (I) reagiert mit Aminohydantoin (II) zu Dantrolen (III), aus dem mit Natrium‐methylat das Natrium‐Salz (IV) erhalten wird.
ChemInform Abstract: POLYNUCLEAR COMPLEXES OF LANTHANIDES WITH NICKEL AND COPPER SCHIFF BASES AS LIGANDS
Authors: SEMINARA A. , GIUFFRIDA S. , MUSUMECI A. , FRAGALA I.
Published: May 2016

Die zwei‐ und dreikernigen Lanthanoid‐Komplexe (I) werden durch l :2.5‐molare Umsetzung entsprechender Lanthanoid(III)‐Salze mit dem Ni‐ oder Cu‐Schiffschen‐Basen‐Komplex in Ethanol synthetisiert.
ChemInform Abstract: UNCOMMON EQUILIBRIUM BETWEEN η1 AND η2 ISOMERS OF SELENOBENZALDEHYDE COMPLEXES
Authors: FISCHER H. , ZEUNER S. , RIEDE J.
Published: May 2016

Die in situ aus dem Komplexion (Ia) dargestellte Verbindung (II) reagiert mit Selenocyanat (III) zu einem Komplex, der in Lösung in einem temperaturabhängigen Gleichgewicht zwischen den if‐Isomeren (IV) und (V) mit E‐ oder Z‐Konfiguration sowie dem nZ‐Isomeren (IV) vorliegt (Nachweis 138 durch IR‐ und Elektronenspektren).
ChemInform Abstract: PHOTOCHEMISTRY OF CYCLOPENTADIENYLCOBALT 1,4‐DIARYLTETRAAZADIENES. EXAMPLES OF CH, CF, AND CC BOND BREAKING
Authors: GROSS M. E. , JOHNSON C. E. , MARONEY M. J. , TROGLER W. C.
Published: May 2016

Die Photolyse der Komplexe (III) unter Bildung der Verbindungen (IV) bzw. (V) und (VI) wird im Hinblick auf den Mechanismus diskutiert.
ChemInform Abstract: REDUCTIVE NITROSYLATION OF TETRAOXOMETALATES. SINGLE‐POT AND A VIRTUALLY SINGLE‐STEP SYNTHESIS OF PENTAKIS(ISOTHIOCYANATO)NITROSYLOSMATE(2‐) AND ITS 1,10‐PHENANTHROLINE AND 2,2′‐BIPYRIDINE DERIVATIVES DIRECTLY FROM OSMIUM TETROXIDE IN AQUEOUS AEROBIC MEDIA
Authors: BHATTACHARYYA R. , SAHA A. M.
Published: May 2016

Durch Reaktion von NHZOH ‐ HCl und NH4NCS mit OsO4 in Wasser bei 80°C wurde eine Lösung (pH 2.6) erhalten, aus der nach Zugabe einer wäßrigen Lösung von [AsPh4]Cl bei 10°C der Komplex (I) kristallin gefällt wurde.
ChemInform Abstract: Synthesis and Characterization of Heterobimetallic Complexes Derived from (o‐(Diphenylphosphino)benzoyl)pinacolone (HacacP). The Structure of PtCl2{Cu(acacP)2}.
Authors: WROBLESKI D. A. , DAY C. S. , GOODMAN B. A. , RAUCHFUSS T. B.
Published: May 2016

Der unsymm. Titelligand reagiert in CHZCIZ mit den Metallkomplexen MC12(cyclooctadien) (M: Pt, Pd), Rh2Cl2(CO)4 und lrCl(CO)2(p‐toluidin) zu den Verbindungen (I), die einer Metallierung durch Cu‐carboxylate unter Bildung der heterobimetallischen Komplexe (IIa), (IIb) bzw. (IV) unterliegen.
ChemInform Abstract: ONE STEP SYNTHESIS OF 2′‐THIOBIOTIN FROM 2′‐BIOTIN
Authors: GASC M. B. , KLAEBE A. , PERIE J. J.
Published: May 2016

Mit dem Lawesson‐Reagens (II) läßt sich Biotin (I)‐in hoher Ausbeute in Thiobiotin (III) überführen.
ChemInform Abstract: ELECTROCHEMICAL PROPERTIES OF BORON SULFIDE‐LITHIUM SULFIDE‐LITHIUM IODIDE VITREOUS ELECTROLYTES
Authors: MENETRIER M. , LEVASSEUR A. , HAGENMULLER P.
Published: May 2016

Bei Glasproben mit 0.28 B283, 0.33 Li3S und 0.39 LiI in massiver Form oder als gepreßte Pulver‐Pellets war die Elektronenleitfähigkeit um einen Faktor von mindestens 10°C kleiner als die L?‐Ionenleitfähigkeit.
ChemInform Abstract: CYCLIC VOLTAMMETRY IN SOLUTIONS OF ALUMINUM BROMIDE AND POTASSIUM BROMIDE IN AROMATIC HYDROCARBONS. III. THE BEHAVIOR OF SILVER AND COPPER
Authors: ELAM M. , PELED E. , GILEADI E.
Published: May 2016

Das elektrochemische Verhalten verdünnter Lösungen von AgBr und CuBr wurde in einer Lösung von 0.8 M KBr und 1.0 M Al2Br6 in Ethylbenzol untersucht.
ChemInform Abstract: PHYSICOCHEMICAL CHARACTERIZATION OF MOLYBDENUM TRIOXIDE‐NAY ZEOLITE CATALYSTS
Authors: CID R. , GIL LLAMBIAS F. J. , FIERRO J. L. G. , LOPEZ AGUDO A. , VILLASENOR J.
Published: May 2016

Proben mit Mo‐lmprägnierungen von l bis I5 Gew.‐"/o MoO3 wurden zur Strukturcharakterisierung u.a. mittels XRD, TEM, IR sowie Messungen der spezifischen Oberflä‐ i che, des Wassergehalts und der Extraktion untersucht.
ChemInform Abstract: 1,3‐DIPOLAR CYCLOADDITION OF HETEROCYCLES. XII. 1,3‐DIPOLAR CYCLOADDITIONS TO 2,3‐BIS(METHOXYCARBONYL)‐7‐OXABICYCLO(2.2.1)‐2,5‐HEPTADIENE, 1,4‐EPOXY‐1,4‐DIHYDRONAPHTHALENE, AND EXO,ENDO‐1,6‐BIS(METHOXYCARBONYL)‐11,12‐DIOXATETRACYCLO(4.4.0.12,5.17,10)‐3,8‐DODECADIENE
Authors: FISERA L. , PAVLOVIC D.
Published: May 2016

Untersucht werden Additionsreaktionen der Titelverbindungen (II), (VII) und (XVII).
ChemInform Abstract: STEREOCHEMISTRY OF THE REACTION OF 7‐SUBSTITUTED NORBORNADIENES WITH IRON CARBONYLS. 2. REACTION OF FE(CO)5 WITH 7‐PHENYL‐ AND 7‐O‐ANISYLNORBORNADIENE
Authors: MARCHAND A. P. , GOODIN D. B. , HOSSAIN M. B. , VAN DER HELM D.
Published: May 2016

Aus den 9‐Aryl‐norbornadienen (I) erhält man mit Eisenpentacarbonyl (II) die Dimeren (III), von denen (IIIa) zu (IV) und (IIIb) zu (V) reduziert wird.
ChemInform Abstract: ELECTROPHILIC AROMATIC SUBSTITUTION WITH A NITRENIUM ION GENERATED FROM N‐CHLORO‐N‐METHOXYAMIDES. APPLICATION TO THE SYNTHESIS OF 1‐METHOXY‐2‐OXINDOLES
Authors: KIKUGAWA Y. , KAWASE M.
Published: May 2016

Die leicht darzustellenden und relativ stabilen N‐ChlonN‐methoxyamide (I), (III), (V) und (VII) reagieren in Gegenwart von Agtlonen (oder anderen Übergangsmetallionen) in saurem Medium unter Spaltung der N‐Cl‐Bindung und Bildung eines Nitreniumions, das dann unter Abspaltung eines Protons in die angegebenen Produkte übergeht.
ChemInform Abstract: 1,3‐DIPOLAR CYCLOADDITION REACTIONS OF ALDONITRONES WITH N‐ARYLMALEIMIDES ‐ SYNTHESIS OF STEREOISOMERIC 3,5‐DIARYL‐2‐PHENYL‐4H‐2,3,3A,5,6,6A‐HEXAHYDROPYRROLO(3,4‐D)ISOXAZOLE‐4,6‐DIONES
Authors: KRISHAN K. , SINGH B.
Published: May 2016

Die Addition der Nitrone (I) an die Maleinimide (II) führt zu Gemischen der stereoisomeren Bicyclen (III) und (IV), deren Strukturen aufgrund der NMR‐Daten zugeordnet werden.
ChemInform Abstract: CHEMICAL MODIFICATION OF SULFAZECIN. SYNTHESIS OF 4‐METHOXYCARBONYL‐2‐AZETIDINONE‐1‐SULFONIC ACID DERIVATIVES
Authors: KISHIMOTO S. , SENDAI M. , TOMIMOTO M. , HASHIGUCHI S. , MATSUO T. , OCHIAI M.
Published: May 2016

Das aus dem lminoglyoxalsäureester (I) und dem Phthalimidoacetylchlorid (II) über eine Ketenreaktion darstellbare β‐Lactam (III) wird in mehreren Stufen in das Carbomethoxyamino‐β‐lactam (IV) umgewandelt.
ChemInform Abstract: ANTIVERTIGO AGENTS. III. SYNTHESIS OF 5,6,7,8‐TETRAHYDRO‐1,6‐NAPHTHYRIDINE METHYL HOMOLOGS
Authors: SHIOZAWA A. , ICHIKAWA Y.‐I. , KOMURO C. , KURASHIGE S. , MIYAZAKI H. , YAMANAKA H. , SAKAMOTO T.
Published: May 2016

Ausgehend vom N‐Benzylnaphthyridiniumbromid (II) werden die isomeren Methyltetrahydronaphthyridine (I) und (III) in mehrstufigen Synthesen hergestellt, das 7‐Methylisomer (V) wird aus dem Nicotinsäure‐N‐benzylamid (IV) in 5 Schritten gewonnen.
ChemInform Abstract: Phosphorus Pentoxide in Organic Synthesis. Part 13. Synthesis of 7‐Phenyl‐7H‐pyrrolo[2,3‐d]pyrimidine‐4‐amines.
Authors: JORGENSEN A. , GIRGIS N. S. , PEDERSEN E. B.
Published: May 2016

Die Reaktion der Pyrrolopyrimidine (I) mit den Arylaminen (II) ergibt die Derivate (III).
ChemInform Abstract: A NEW ONE POT PREPARATION OF 2‐N,N‐DIALKYLAMINO‐1,3‐BENZOXAZINES AND NAPHTH(1,2‐E)(1,3)OXAZINES FROM CORRESPONDING ORTHO‐HYDROXYNITRILES AND PHOSGENIMINIUM SALTS
Authors: KOKEL B. , MENICHI G. , HUBERT‐HABART M.
Published: May 2016

Aus den 2‐Hydroxy‐benzonitrilen (I) erhält man bei der Kondensation mit Phosgeniminium‐Salzen wie (H) die Kondensationsprodukte (III), die zu den Z‐Dialkylamino‐l ,3‐benzoxazinen (IV) hydrolysiert werden.
ChemInform Abstract: COMPOUNDS OF PENTACOORDINATE (10‐B‐5) AND HEXACOORDINATE (12‐B‐6) HYPERVALENT BORON
Authors: LEE D. Y. , MARTIN J. C.
Published: May 2016

Das Dilithioderivat (II) des Pyridindiols (I) reagiert mit BCI3 in hohen Ausb. (keine genauen Angaben) zum Chloroborat (III).
ChemInform Abstract: SILACYCLOPROPENES. I. SYNTHESIS AND PROPERTIES OF SOME SILACYCLOPROPENES
Authors: SEYFERTH D. , ANNARELLI D. C. , VICK S. C.
Published: May 2016

Die thermische Zersetzung von Hexamethylsiliran (I) in Gegenwart verschiedener disubstituierter Acetylene (II) liefert unter Addition von Dimethylsilylen an die Acetylenbindungen .eine Reihe von relativ stabilen, isolierbaren, aber extrem reaktionsfreudigen Silirenen (III).
ChemInform Abstract: METAL ION ENCAPSULATION: COBALT CAGES DERIVED FROM POLYAMINES, FORMALDEHYDE, AND NITROMETHANE
Authors: GEUE R. J. , HAMBLEY T. W. , HARROWFIELD J. M. , SARGESON A. M. , SNOW M. R.
Published: May 2016

Die Synthese der Komplexe (Ia) bzw. (Ib) aus Tris‐[ethylendiaminl‐Coull) bzw. dem Co(III)‐Komplex von 5‐(4‐Amino‐2‐a2abutyl)‐5‐methyl‐3,7‐diaza‐1,9‐nonandiamin durch Reaktion mit Formaldehyd und Nitromethan in wäßriger Lösung wird beschrieben und ein Mechanismus vorgeschlagen.
ChemInform Abstract: BIOSYNTHESIS OF PORPHYRINS AND CORRINS. DIRECT OBSERVATION OF AN ENZYME‐SUBSTRATE COMPLEX BY TRITIUM NMR SPECTROSCOPY
Authors: EVANS J. N. S. , FAGERNESS P. E. , MACKENZIE N. E. , SCOTT A. I.
Published: May 2016

Bei der durch Porphobilinogen (PBCD‐Desaminase katalysierten Kondensation von 4 molen PBG (I) zu Präurobilinogen (III) und Überführung in Urobilinogen (II) wird anhand eingehender NMR‐Untersuchungen unter Einsatz entsprechender tritiierter Substrate das Auftreten eines Enzym‐Substrat‐Komplexes nachgewiesen.
ChemInform Abstract: STEREOSELECTIVE SYNTHESIS OF 11α‐CYANO‐D‐HOMOEQUILENIN METHYL ETHER
Authors: BANERJEE D. K. , KASTURI T. R. , PURUSHOTHAM V.
Published: May 2016

Die Cycloalkandione (II) reagieren mit den Naphthylacrylnitrilen (I) zu den Addukten (III), von denen (IIIb) über (VI) in den Cyan‐homoequilenin‐methylether (VII) übergeführt wird.
ChemInform Abstract: FORMATION AND REACTIONS OF THE CYCLIC TAUTOMERS OF TRYPTOPHANS AND TRYPTAMINES. VII. HYDROXYLATION OF TRYPTOPHANS AND TRYPTAMINES
Authors: TANIGUCHI M. , ANJIKI T. , NAKAGAWA M. , HINO T.
Published: May 2016

Das N‐geschützte Tryptophan (I) wird nach Umlagerung in sein tricyclisches Tautomer (II) mit Frernys Salz (III) oder Pb(IV)‐acetat (IV) zum Chinonimin (V) oxidiert, das nach Reduktion mit NaBH4 zum Phenol (VI) unter Ringöffnung das Hydroxytryptophan (VII) liefert.
ChemInform Abstract: STUDIES ON PEPTIDES. CXXI. NIN‐MESITYLENESULFONYLTRYPTOPHAN, A NEW DERIVATIVE E FOR PEPTIDE SYNTHESIS
Authors: FUJII N. , FUTAKI S. , YASUMURA K. , YAJIMA H.
Published: May 2016

Der aus dem geschützten Tryptophan (I) mit Benzylbromid (II) darstellbare Benzylester (III) Iäßt sich mit Mesitylsulfonylchlorid (IV) am Indol‐ stickstoff zum Sulfonamid (V) umsetzen.
ChemInform Abstract: PHOTOELECTROCHEMICAL PROPERTIES OF α‐ AND β‐ZINC PHOSPHIDE (ZNP2) ELECTRODES AND POWDERS
Authors: THEWISSEN D. H. M. W. , TINNEMANS A. H. A. , VAN DER ZOUWEN‐ASSINK E. A. , MACKOR A. , VON KAENEL H. + , HAUGER R. , WACHTER P.
Published: May 2016

Das erstmals untersuchte PEC‐Verhalten von tetragonalem α‐ZnP2 (p‐Typ; Einkristallelektroden) zeigte gute optische Eigenschaften (Absorption eines großen Teils des Sonnenspektrums).
ChemInform Abstract: FERROUS ION CATALYSIS OF REACTIONS OF NUCLEOPHILES WITH ARYL HALIDES
Authors: GALLI C. , BUNNETT J. F.
Published: May 2016

In Gegenwart von Fe(II)‐Katalysatoren erhält man aus den Halogenbenzolen (I) oder (IV) mit dem Anion (II) das Keton (III).
ChemInform Abstract: OXYMETHYLATIVE OPENING OF OXIRANES LEADING TO 1,3‐DIOL DERIVATIVES BY COBALT CARBONYL CATALYZED REACTION WITH A HYDROSILANE AND CARBON MONOXIDE
Authors: MURAI T. , KATO S. , MURAI S. , TOKI T. , SUZUKI S. , SONODA N.
Published: May 2016

Durch Umsetzen von Oxiranen mit Trialkylsilanen und CO in Gegenwart von Co3(CO)8 als Katalysator erfolgt unter Ringöffnung und CO‐Einschub die Bildung von lß‐Disilyloxyderivaten, die weiter zu 1,3‐Diolen umgesetzt werden können.
ChemInform Abstract: THE MECHANISM OF BOROHYDRIDE REDUCTIONS. REACTIONS OF GAS‐PHASE BOROHYDRIDE ION WITH CARBONYL GROUPS BY ION CYCLOTRON RESONANCE SPECTROSCOPY
Authors: KAYSER M. M. , MCMAHON T. B.
Published: May 2016

Mit Hilfe der Ionen‐Cyclotron‐Resonanzspektroskopie (lCR) wird die Reduktion von Carbo‐ nylverbindungen wie (markiertem) Formaldehyd mit Boranat in der Gasphase untersucht.
ChemInform Abstract: DESIGN, SYNTHESIS, AND TESTING OF POTENTIAL ANTISICKLING AGENTS. 4. STRUCTURE‐ACTIVITY RELATIONSHIPS OF BENZYLOXY AND PHENOXY ACIDS
Authors: ABRAHAM D. J. , KENNEDY P. E. , MEHANNA A. S. , PATWA D. C. , WILLIAMS F. L.
Published: May 2016

Carbonsäuren (I) und (II) sowie weitere Carbonsäuren, z.B. der Struktur (III), werden dargestellt und als lnhibitoren der Hämo lobin S‐Gelierung untersucht.
ChemInform Abstract: ((ARYLCARBONYL)OXY)PROPANOLAMINES. 1. NOVEL β‐BLOCKERS WITH ULTRASHORT DURATION OF ACTION
Authors: KAM S.‐T. , MATIER W. L. , MAI K. X. , BARCELON‐YANG C. , BORGMAN R. J. , O'DONNELL J. P. , STAMPFLI H. F. , SUM C. Y. , ANDERSON W. G. , GORCZYNSKI R. J. , LEE R. J.
Published: May 2016

Dargestellt und als β‐Blocker untersucht werden die Amine (I)‐(III).
ChemInform Abstract: ANTIVIRAL AGENTS, XXVI. SYNTHESIS OF 4,6‐DISUBSTITUTED 2‐(CYANOAMINO)PYRIMIDINES AND STUDIES OF THEIR STRUCTURE BY MASS SPECTROSCOPY
Authors: KREUTZBERGER A. , SELLHEIM M.
Published: May 2016

Cyanoguanidin (I) reagiert mit dem Diketon‐Enol (II) zu dem Cyanarninopyrimidin (III), dessen MS‐Abbau ausführlich diskutiert wird.
ChemInform Abstract: A NOVEL SYNTHESIS OF APORHOEADANES
Authors: RUCHIRAWAT S. , LERTWANAWATANA W. , THIANPATANAGUL S. , CASHAW J. L. , DAVIS V. E.
Published: May 2016

Das Dimethoxy‐isochinolin (I) wird mit 2‐Chlormethyl‐benzoylchlorid (II) in Gegenwart von Basen in ein Addukt umgewandelt, das bei der Behandlung mit NaOH‐/Methanol die beiden Verbindungen (III) und (IV) ergibt.
ChemInform Abstract: GENERATION AND REACTIONS OF TRICARBONYLFERRATE(1‐) ANION RADICAL IN A FLOWING AFTERGLOW APPARATUS
Authors: MCDONALD R. N. , CHOWDHURY A. K. , SCHELL P. L.
Published: May 2016

Unter den Bedingungen großer Emissionsströme wird durch dissoziative Kupplung von Elektronen hoher Energie mit Fe(CO)5 das Titelradikalion (CO)3Fe" erzeugt.
ChemInform Abstract: KINETICS AND MECHANISM OF SUBSTITUTION REACTIONS OF η5‐CYCLOPENTADIENYLDICARBONYLRHODIUM(I) DERIVATIVES. RATE ENHANCEMENT OF ASSOCIATIVE SUBSTITUTION IN CYCLOPENTADIENYLMETAL COMPOUNDS
Authors: REREK M. E. , BASOLO F.
Published: May 2016

Die Kinetik der CO‐Monosubstitution der Verbindungen (I) mit Triphenylphosphin wird untersucht.
ChemInform Abstract: SYNTHETIC VARIATIONS OF THE PROGESTERONE ANTAGONIST RU 38 486
Authors: NEEF G. , SAUER G. , SEEGER A. , WIECHERT R.
Published: May 2016

Bei der Bestrahlung des 17‐Ketoöstran‐Derivates (I) erfolgt eine Umlagerung zu dessen C‐l 3‐Epimeren (II); in gleicher Weise wird die zu (I) am C‐1 1 epimere Verbindung (III) zu (IV) umgelagert.
ChemInform Abstract: MOLECULAR STRUCTURE OF DIAMINOTRIFLUOROPHOSPHORANE, PF3(NH2)2, IN THE GAS PHASE
Authors: MARSDEN C. J. , HEDBERG K. , SHREEVE J. M. , GUPTA K. D.
Published: May 2016

Nach Elektronenbeugungsuntersuchungen bei 50°C bilden die Schweratome eine trigonale Bipyramide in C2v‐Symmetrie, in der die N‐Atome äquatoriale Lagen einnehmen.
ChemInform Abstract: CHIRAL ANALYSIS OF THE REACTION STAGES IN THE EDMAN METHOD FOR SEQUENCING PEPTIDES
Authors: DAVIES J. S. , MOHAMMED A. K. A.
Published: May 2016

Aus L‐Phenylalanin (I) wird durch Nitrierung, Einführung der Schutzgruppe und Reduktion die Aminosäure (II) erhalten, die nach ihrer Methylierung ohne Racemisiemng mit "Ihiophosgen zum L‐Isothioeyano‐phenylalanin (III) reagiert.
ChemInform Abstract: THERMOLYSIS OF PERFLUOROALKANESULFONYL HALIDES
Authors: OUDRHIRI‐HASSANI M. , BRUNEL D. , GERMAIN D. , COMMEYRAS A.
Published: May 2016

Die thermisch initiierte Zersetzung der PerfluoralkansulfonsäureChloride (I) liefert unter SOZ‐Eliminierung die Perfluoralkylchloride (II).
ChemInform Abstract: ONE‐POT SYNTHESIS OF DIVINYLOXYPROPENES BY REACTION OF GLYCEROL WITH ACETYLENE
Authors: TROFIMOV B. A. , MALYSHEVA S. F. , SIGALOV M. V. , VYALYKH E. P. , KALABIN G. A.
Published: May 2016

Glycerin (I) reagiert mit Acetylen (II) unter stark basischen Bedingungen über die Vinylether (III) letztlich zu den Folgeprodukten (IV)‐(VIII).
ChemInform Abstract: A NEW PREPARATIVE METHOD FOR (E)‐2,3‐DIARYLBUT‐2‐ENEDIALS
Authors: TODA F. , TAKEHIRA Y. , KATAOKA Y. , MORI K. , SATO T. , SEGAWA M.
Published: May 2016

Die durch Cyclisierung der β‐Diketone (I) zu den Cyclobutenen (II) und deren Bromierung mit N,N′‐Dibromdimethylhydantoin (DBDMH) erhaltenen Dibromcyclobutene (III) werden zu den Dialdehyden (IV) gespalten.
ChemInform Abstract: PARTIALLY FLUORINATED HETEROCYCLIC COMPOUNDS. PART 19. THE FORMATION OF FISCHER INDOLE PRODUCTS FROM A SERIES OF HYDRAZONES DERIVED FROM PENTAFLUOROPHENYLHYDRAZINE AND 1,3,4,5,6,7,8‐HEPTAFLUORO‐2‐NAPHTHYLHYDRAZINE. THE SURPRISING LOSS OF ORTHO FLUORINE
Authors: BENKE F. D. , BROOKE G. M.
Published: May 2016

Die Umsetzungen der Pentafluorphenylhydrazone (I) sowie der Heptafluornaphthylhydrazone (III) in siedendem Tetralin liefert komplexe Produktgemische, aus denen jeweils die lndole (II) sowie (IV) isoliert und charakterisiert werden.
ChemInform Abstract: HYDROFORMYLATION AS A SIMPLE AND EFFICIENT ONE CARBON HOMOLOGATION OF HOMOALLYLIC ALCOHOLS. SYNTHESIS OF PRELOG‐DJERASSI LACTONE
Authors: WUTS P. G. M. , OBRZUT M. L. , THOMPSON P. A.
Published: May 2016

Aus den Homoallylalkoho‐ len (I) erhält man bei der Hydroformylierung die Lactone (II), aus (III) entstehen analog die isomeren Lactone (IV).
ChemInform Abstract: THE PREPARATION, BORON‐11, PROTON, AND PHOSPHORUS‐31 NUCLEAR MAGNETIC RESONANCE SPECTRA, AND PROPERTIES OF ALKYLIDENETRIPHENYLPHOSPHORANE‐TRIBORANE(7), P(C6H5)3CHRB3H7 (R = H, CH3, OR C6H5)
Authors: CHOI P. C. , MORRIS J. H.
Published: May 2016

Die aus den Phosphoniumbromiden (I) durch NaH‐Behandlung in THF erzeugten P‐Ylide reagieren mit B3H7 zu den Titelverbindungen (ll).
ChemInform Abstract: ELECTROCHEMICAL STUDIES OF FERROCENE AND FERROCENIUM ION IN ALUMINUM CHLORIDE‐N‐(1‐BUTYL)PYRIDINIUM CHLORIDE IONIC LIQUID
Authors: KARPINSKI Z. J. , NANJUNDIAH C. , OSTERYOUNG R. A.
Published: May 2016

Der Elektronenübertragungsprozeß Ferrocen/Ferrocenium‐Ion wurde bei 40°C alsFunktion der Zusammensetzung der Schmelze cyclisch‐voltammetrisch untersucht.
ChemInform Abstract: IRON(III) PHTHALOCYANINES: OXIDATION AND SPIN STATES OF IRON IN IRON PHTHALOCYANINES WITH CARBOXYL GROUPS
Authors: KOBAYASHI N. , SHIRAI H. , HOJO N.
Published: May 2016

Mößbauer‐ und ESR‐Spektren zeigen, daß die Verbindungen (I) Mischungen aus high‐spin‐Fe(III)‐ und low‐spin‐Fe(III)‐Komplexen sind, und daß in (Ib) im festen Zustand Spezies mit einem intermediären spin‐Zustand vorliegen können.
ChemInform Abstract: SYNTHESIS AND STUDY OF IMIDAZOLE‐BEARING COPPER(I) COMPLEXES AND THEIR REVERSIBLE REACTION WITH DIOXYGEN
Authors: MERRILL C. L. , WILSON L. J. , THAMANN T. J. , LOEHR T. M. , FERRIS N. S. , WOODRUFF W. H.
Published: May 2016

Die Cu(I)‐ Komplexe (Ia) und (IIIa) wurden durch Kondensation von 2,6‐Diacetylpyridin mit entsprechenden Aminen in MeOH und anschließende Zugabe von [Cu(MeCN)4]BF4 in MeCN dargestellt.
ChemInform Abstract: MAGNETIC AND SPECTROSCOPIC PROPERTIES OF DIMERIC COPPER(II) COMPLEXES OF N‐BENZYLOXYCARBONYL‐SUBSTITUTED AMINO ACID ANIONS
Authors: ANTOLINI L. , MENABUE L. , PELLACANI G. C. , SALADINI M. , BATTAGLIA L. P. , BONAMARTINI CORRADI A. , MARCOTRIGIANO G.
Published: May 2016

Die substituierten Aminosäuren reagieren als Na‐Salze mit Cu‐perchlorat im Verhältnis 2 : I in EtOH zu den Titelkomplexen (I), deren physikalische Eigenschaften auf starke antiferromagnetische Wechselwirkungen zwischen den Cu‐Ionen innerhalb der Paare über Carboxylatbrücken hindeuten.
ChemInform Abstract: UTILIZATION OF SULFUR‐CONTAINING LEAVING GROUP. PART 6. PEPTIDE‐BOND FORMATION, CHEMOSELECTIVE ACYLATION OF AMINO ACIDS, AND CROSSLINKING REACTION BETWEEN AMINO ACIDS UTILIZING A FUNCTIONAL FIVE‐MEMBERED HETEROCYCLE, 1,3‐THIAZOLIDINE‐2‐THIONE
Authors: NAGAO Y. , MIYASAKA T. , SENO K. , FUJITA E. , SHIBATA D. , DOI E.
Published: May 2016

Zur Durchführung der im Titel genannten Umsetzungen werden die Thiazolidine (I) sowie (XIII) und (XV) eingesetzt: l. Die aus Aminosäuren (II) mit (Ia) erhältlichen Derivate (III) werden mit Aminosäurekomponenten (IV) zu Dipeptiden (V) kondensiert; Weiterreaktion wie angegeben führt zu den Peptiden (VI) bzw. (VII).
ChemInform Abstract: RAMAN SPECTRA OF CO(NH3)6X3 (X = CL, BR, I) COMPLEXES
Authors: DUBICKI L. , WILLIAMSON B.
Published: May 2016

Bei den Einkristallmessungen zwischen 40 und 3 l0 Kkonnte die kontroverse Feinstruktur nahe 500 cm‐1 auf der Basis von nichtäquivalenten Gitterplätzen und von NDylsotopen‐ Verschiebungen für die Valenzschwingungen erklärt werden.
ChemInform Abstract: SYNTHESIS AND PROPERTIES OF 4‐ARYLAZO DERIVATIVES OF ISOXAZOLE AND ISOXAZOLINE
Authors: MALYUTA N. G. , KHISAMUTDINOV G. KH. , DEMINA L. A.
Published: May 2016

Die 5‐Aryl‐4‐nitroisoxazoline (I) werden in die Natriumsalze (II) übergeführt, die dann mit den Aryldiazoniumchloriden (III) in schwach basischem bis neutralem Milieu unter Abspaltung von HNO2 in die 4‐Arylazoderivate (IV) übergehen.
ChemInform Abstract: DOUBLE ALDOL CONDENSATION: STEREOSELECTIVE SYNTHESIS OF MASKED AND UNMASKED β,β′‐DIHYDROXY KETONES
Authors: ANNUNZIATA R. , CINQUINI M. , COZZI F. , RESTELLI A.
Published: May 2016

Die Dihydroisoxazole (I) reagieren mit Aldehyden unter Addition zu den Alkoholen (II), die zu den Alkoholen (III) bzw. den Ketodiolen (IV) gespalten werden können.
ChemInform Abstract: PROPERTIES OF 3‐(PENTAFLUOROISOPROPENYL)‐5,5‐BIS(TRIFLUOROMETHYL)‐1,4,2‐DIOXAZOLINE
Authors: VASIL'EV N. V. , KHOKHLOVA S. A. , KOLOMIETS A. F. , SOKOL'SKII G. A.
Published: May 2016

Die Titelverbindung (I) reagiert mit Wasser im Überschuß unter Hydrolyse an der C = C‐Doppelbindung und Abspaltung von CO2 und HF zu dem Derivat (II).
ChemInform Abstract: NOVEL AMINO‐SUBSTITUTED 3‐QUINOLINECARBOXYLIC ACID ANTIBACTERIAL AGENTS: SYNTHESIS AND STRUCTURE‐ACTIVITY RELATIONSHIPS
Authors: WENTLAND M. P. , BAILEY D. M. , CORNETT J. B. , DOBSON R. A. , POWLES R. G. , WAGNER R. B.
Published: May 2016

Dargestellt werden die Oxodihydrochinolinone (VIII) und (IX), deren antibakterielle Aktivität bestimmt wird.
ChemInform Abstract: LOW‐COORDINATED PHOSPHORUS COMPOUNDS. 34. INSERTION OF CARBON DIOXIDE INTO DISILYLATED PHOSPHINES
Authors: APPEL R. , LAUBACH B. , SIRAY M.
Published: May 2016

Aus den Bistrimethylsilyl‐phosphinen (Ia)‐(Ic) erhält man mit Kohlendioxid die Einschiebungsprodukte (II), die im Gleichgewicht mit den Umlagerungsprodukten (III) stehen.
ChemInform Abstract: ORGANOPHOSPHORUS CHEMISTRY. IV. SYNTHESIS AND REACTIONS OF 2‐ETHOXY‐6‐OXO‐1,2‐AZAPHOSPHINANE 2‐OXIDE
Authors: HEWITT D. G. , TEESE M. W.
Published: May 2016

Die Titelverbindung (III) wird durch Cyclokondensation des wie aufgezeichnet dargestellten Aminophosphoryl‐buttersäureesters (IIb) gebildet.
ChemInform Abstract: STEROIDS. 2. SYNTHESIS OF C‐18 FUNCTIONALIZED STEROIDS VIA THE SMITH‐HUGHES ROUTE
Authors: PILLAI K. M. R. , MURRAY W. V. , SHOOSHANI I. , WILLIAMS D. L. , GORDON D. , WANG S. Y. , JOHNSON F.
Published: May 2016

Gemäß Formelschema erhält man über die Schlüsselverbindung (V) das Diol (VI) sowie die Ketone (VIII), (X) und (XI), von denen die Ketone nur geringe Aktivität im Clauberg‐ und anti‐Clauberg‐Versuch besitzen.
ChemInform Abstract: N‐HYDROXY AMIDES. II. N‐BENZYLOXY α‐AMINO ACID N‐HYDROXYSUCCINIMIDE ESTERS AND SYNTHESIS OF A HEXAPEPTIDE HAVING AN ALTERNATING N‐HYDROXY AMIDE‐AMIDE SEQUENCE
Authors: SHIMIZU K. , NAKAYAMA K. , AKIYAMA M.
Published: May 2016

Die Acyclierung einer Reihe von N‐Benzyloxy‐ aminosäuren (II) bzw. Adipeptiden (IV) mit N‐Phthaloylglycin (I) (Acylchlorid‐ bzw. Mischanhydrid‐Methode) zeigt eine Abnahme der Ausb. beim Produkt (III) bzw. (V) mit wachsender Sperrigkeit des Aminosäurebausteins A (Diagramm).
ChemInform Abstract: NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 47. A GENERAL, EFFICIENT, AND CONVENIENT SYNTHESIS OF DIARYLHEPTANOIDS
Authors: KATO N. , HAMADA Y. , SHIOIRI T.
Published: May 2016

Die aus den Phenylpropionsäuren (I) durch Kondensation mit Cyanessigsäurebutylester (II) in Gegenwart von Diethylphosphorocyanid über die Nitrile (IV) hergestellten Aldehyde (V) lassen sich mit Grignard‐Verbindungen (VI) zu β‐Ketolen (VIII) kondensieren.
ChemInform Abstract: 2‐Amino‐Δ1‐pyrrolinium‐Salze.
Authors: KONTUNENKO V. A. , SOLOSHONOK L. V. , TYLTIN A. K. , BABICHEV F. S.
Published: May 2016

Primäre Amine (II) reagieren bei 120°C mit der vorgelegten äquivalenten Menge eines γ‐Halogen‐butyronitrils (I) nach 8‐10 Stdn. zu 2‐Amino‐Δ1‐pyrrolinium‐Salzen (III).
ChemInform Abstract: SYNTHESIS OF THE HEXAAMINOBENZENE DERIVATIVE HEXAAZAOCTADECAHYDROCORONENE (HOC) AND RELATED CATIONS
Authors: BRESLOW R. , MASLAK P. , THOMAIDES J. S.
Published: May 2016

Katalytische Hydrierung (10% Pd‐Kohle, EtOAc) von 1,3,5‐Trinitro‐2,4,6‐triamino‐benzol ergibt Hexaaminobenzol (Ia) (80% Rohausb.), das mit Chloracetylchlorid direkt in das Hexaamid (Ib) übergefühn wird (59%, bezogen auf das Trinitrotriaminobenzol).
ChemInform Abstract: TRIALKYL(2‐NITRO‐1‐ALKENYL)SILANES. SYNTHESIS AND DIELS‐ALDER REACTION
Authors: HAYAMA T. , TOMODA S. , TAKEUCHI Y. , NOMURA Y.
Published: May 2016

Aus den Silylalkenen (I) entstehen mit Phenylselenenylhalogenid und Sibernitrat/Hg(Il)‐ Chlorid die Nitro‐selenylether (III).
ChemInform Abstract: SYNTHESIS, CHARACTERIZATION, AND EQUILIBRIUM STUDIES OF GROUP VIB INTRAMOLECULAR METALLOESTERS: CRYSTAL STRUCTURE OF TRANS‐(η5‐C5H4)CH2CH2O2CW(CO)2PPH3
Authors: COOLBAUGH T. S. , SANTARSIERO B. D. , GRUBBS R. H.
Published: May 2016

Die intramolekulare Aktivierung von CO in (II) durch die Hydroxyalkylgruppe am Cyclopentadienylring nach Deprotonierung durch Basen ist von der CH2‐Kettenlänge abhängig.
ChemInform Abstract: β‐LACTAM ANTIBIOTICS: A FORMAL STEREOCONTROLLED TOTAL SYNTHESIS OF (.+‐.)‐THIENAMYCIN
Authors: GRIECO P. A. , FLYNN D. L. , ZELLE R. E.
Published: May 2016

Ausgehend vom Carbinol (Ib), das aus dem Aldhyd (Ia) mit Me2Cu(C N)Li2 bei ‐78°C zugänglich ist, wird über die angegebenen Stufen das Debenzylierungsprodukt (IXb) des Azetidinons (IXb) synthetisiert, aus dem das Derivat (X) zugänglich ist.
ChemInform Abstract: HYDROXIDE MONOHYDRATES OF POTASSIUM AND RUBIDIUM; COMPOUNDS WITH ATOMIC ARRANGEMENTS WHICH SUGGEST THE FORMULA K(H2O)OH AND RB(H2O)OH
Authors: JACOBS H. , TACKE T. , KOCKELKORN J.
Published: May 2016

Durch Umkristallisieren der feinkristallinen Substanzen in überkritischem NH; im Hochdruckautoklaven (K(H2O)OH: 410‐390 K, 5 kbar, 7‐ l0 d; Rb(H2O)OH: 420‐400 K, 1.8 kbar, 6 d) werden zur Strukturbestimmung geeignete Einkristalle erhalten.
ChemInform Abstract: CUBIC HIGH‐TEMPERATURE MODIFICATION OF CALCIUM OXOTANTALATE (CATA2O6)
Authors: TIEDEMANN P. , MUELLER‐BUSCHBAUM HK. +
Published: May 2016

Mischungen aus Ta2O5 und CaCO3 in Tablettenform wurden zum Abbau des Carbonats 12 h auf 1000°C und anschließend mit einem CO2‐Laser (500 Watt) auf 2200°C Oberflächentemp.
ChemInform Abstract: THE DEFECT STRUCTURE OF NICKEL OXIDE SURFACES AS REVEALED BY PHOTOELECTRON SPECTROSCOPY
Authors: ROBERTS W. , SMART R. ST. C.
Published: May 2016

Im Hinblick auf die starke Abhängigkeit der Oberflächenreaktionen (incl.
ChemInform Abstract: PHOTOLUMINESCENCE OF ZINC OXIDE POWDER AS A PROBE OF ELECTRON‐HOLE SURFACE PROCESSES
Authors: ANPO M. , KUBOKAWA Y.
Published: May 2016

ZnO‐Pulver zeigt bei Anregung durch Bandlückenbestrahlung Photolumineszenz mit einem scharfen Emissionspeak bei z 380 nm und einem breiten Peak bei z 500 nm, die beide durch O2‐Zusatz gelöscht werden.
ChemInform Abstract: GROWTH OF INDIUM ANTIMONIDE AND INDIUM ARSENIDE ANTIMONIDE (INAS1‐XSBX) BY OM‐CVD
Authors: CHIANG P. K. , BEDAIR S. M.
Published: May 2016

Epitaktische Schichten von lnSb und InAs, ‐"Sb" wurden durch OM‐CVD (organometallic chemical vapor deposition) mitt‐els Triethylindium, Trimethylantimon und Arsin (AsH3) auf großflächigen GaAs‐ und lnSb‐Substraten erhalten.
ChemInform Abstract: MOLTEN CARBONATE FUEL CELL CATHODE MATERIALS STUDY
Authors: BAUMGARTNER C. E. , ARENDT R. H. , IACOVANGELO C. D. , KARAS B. R.
Published: May 2016

Ca. 40 Materialien (meist Oxidmischungen) wurden bez. ihrer Elektronenleitfähigkeit und ihrer Stabilität in einer (Elektrolyt‐)Schmelze aus 62 moI‐% Li2CO3 und 38 mol‐% KzCOg bei 923 K unter einer 30% COZ/Luft‐Atmosphäre untersucht.