bluuebunny/crossref_metadata_2025 huggingface dataset:
الدور التركي في ليبيا: الدوافع والمكاسب
Authors: Humam Khudhair Muttlak
Published: November 2022

من المعلوم ان تركيا تلعب دوراً محورياً في ليبيا، وذلك من خلال الدعم الذي تقدمه الى الحكومة الشرعية في ليبيا، وهذا الدعم يشمل مجال الطاقة والبناء وغيرها من البنى التحتية، ومن جانب اخر فأنها تعتقد بأن وجودها في ليبيا يعزز نفوذها ويبرز قوتها. اذ تسعى إلى ترسيخ وتعميق نفوذها هناك لتحقيق عدة عوامل أبرزها: إنشاء نظام إقليمي جديد لتحويل دوره من مجرد لاعب إقليمي إلى لاعب رئيسي أكثر قوة وتميزًا، كما تطمح تركيا إلى أن تكون القوة الأكثر نفوذاً في صياغة مستقبل ليبيا السياسي، كما ان تأمين موطئ قدم في ليبيا سيوفر لتركيا مصدراً مستقراً وآمناً للنفط والغاز، وهو ما تفتقر إليه.
الصراع في ليبيا واثره على دول الجوار: مصر والجزائر
Authors: ورقاء محمد رحيم
Published: November 2022

تحاول هذه الدراسة تسليط الضوء على موضوع النزاعات المسلحة في ليبيا من حيث الاسباب التي دفع الى تحول المظاهرات السلمية ضد النظام الليبي سريعاً الى نزاعات مسلحة مابين المتظاهرين وانصار النظام الليبي ، وحتى مع سقوط النظام الليبي بمقتل الرئيس اليبي السابق معمر القذافي لم تتوقف تلك النزاعات بل ازدادت، كما تحاول هذه الدراسة معرفة كيف اثرت تلك النزاعات على دول الجوار الليبي ومنها الجزائر ومصر وذلك من خلال دراسة اهم التهديدات الامنية والسياسية والاقتصادية على تلك الدولتين التي صاحبت مرحلة النزاعات المسلحة في ليبيا .
رؤية مصر 2030 ودورها في تحقيق الامن المجتمعي بعد العام 2014
Authors: ولاء علي فرحان  , هشام حكمت عبد الستار
Published: November 2022

ان هذا البحث يقدم دراسة حول مفهوم الامن المجتمعي، ورؤية مصر 2030، وكيف ان هذه الرؤية تسعى لتحقيق الامن المجتمعي بمفهومه الحديث، وحيث اعتمدت الدول الأعضاء بالأمم المتحدة أجندة 2030 للتنمية المستدامة في العام 2015، والتي وضعت مجموعة من الأهداف التنموية يتم تحقيقها حتى حلول العام 2030، وجاءت رؤية مصر متوافقة مع الرؤية الاممية لكن بشيء من الخصوصية، وضعت الحكومة المصرية في العام 2016 إستراتيجيتها للتنمية المستدامة تحت عنوان "رؤية مصر 2030"، لترسم إجراءاتها على مدى السنوات الخمسة عشر المقبلة، وتعمل كإستراتيجية إنمائية طويلة الأجل تغطي الأبعاد الإنمائية الثلاثة: الاقتصادية والاجتماعية والبيئية، ولكن هذه الاستراتيجيات لم تخلو من تحديات واجهتها جعلت من الصعوبة تحقيق اهدافها التنموية.
Quels mélanges de semences sauvages et locales pour revégétaliser les milieux ouverts dégradés des Alpes ?
Authors: HUC Stéphanie , VAN ES Jérémie , ABDULHAK Sylvain , SPIEGELBERGER Thomas , DUPRÉ LA TOUR Alice , PLANCHE Julien
Published: November 2022

Identifier les espèces appropriées pour revégétaliser représente un défi pour les praticiens et les scientifiques, en particulier dans les régions montagneuses où les projets de restauration sont nombreux et donnent souvent des résultats mitigés. Jusqu’à présent, seules les espèces d’origine exogène dites « commerciales » sont utilisées pour revégétaliser les stations de ski et autres sites aménagés. Dans cette étude, nous avons cherché à développer une méthode qui cible des espèces sauvages d’origine locale adaptées aux projets de revégétalisation, en tenant compte de facteurs écologiques, techniques et économiques, et à fournir des listes d’espèces servant de base à la collecte et la production de semences afin de développer une filière de semences herbacées sauvages et locales dans les Alpes françaises.Deux mélanges sont proposés pour répondre aux besoins des aménageurs en montagne alpine, l’un pour la moyenne montagne (900-1500 m d’altitude), l’autre pour les zones d’altitude (1500-2800 m d’altitude). Chaque mélange est composé d’espèces « principales », pionnières et structurantes des communautés végétales, indispensables à la réussite des semis. Les espèces « complémentaires » enrichissent le mélange selon les conditions environnementales du milieu (pH, humidité, objectifs de la revégétalisation, etc.). Certaines de ces espèces sont déjà récoltées dans le milieu naturel et mises en production selon le référentiel technique de la marque « Végétal local », afin de garantir la traçabilité des graines et leur diversité génétique. Ces mélanges constituent une aide pour les praticiens, décideurs et prescripteurs impliqués dans la restauration écologique en montagne alpine. L’approche proposée présente une plus-value méthodologique, transférable à d’autres territoires afin de développer les filières de production dans les régions françaises.
Mitos, Lendas e Religiões: um diálogo interdisciplinar
Authors: Bomfá Cláudia Regina Ziliotto , Cardozo João Alles , Bronzoni Raquel Mota de Souza , Corrêa Fabio Henrique , Carlos Giovana da Rosa
Published: November 2022

O presente artigo relata as experiências decorridas no projeto de extensão do grupo Programa de Educação Tutorial Ciências Sociais Aplicadas (PET CiSA) da Universidade Federal de Santa Maria, que visa o conhecimento e aprendizado através de ensino-pesquisa-extensão. Esse projeto foi desenvolvido em duas instituições: no primeiro semestre de 2018, na Escola Municipal de Ensino Fundamental Vicente Farencena, com duas turmas de oitavo ano, e, no segundo semestre, na Escola Estadual de Ensino Médio Professora Naura Teixeira Pinheiro, com uma turma de oitavo ano. A proposta era discutir temas sociais transversais e os fenômenos naturais, com a ferramenta do imaginário mitológico. Palavras-chave: extensão, interdisciplinaridade, mitologia, educação.
Predictive Power of a Body Shape Index (ABSI) for Diabetes Mellitus and Arterial Hypertension in Peru: Demographic and Health Survey Analysis - 2020
Authors: Heredia Andony Ojeda , Torres-Malca Jenny Raquel , Zuzunaga-Montoya Fiorella Elvira , Vera-Ponce Victor Juan , Cruz-Ausejo Liliana , Cruz-Vargas Jhony A. De la
Published: November 2022

Introduction: Given the relationship between obesity and type 2 diabetes mellitus (T2DM) and hypertension, an indicator of body fat, A Body Shape Index (ABSI), has been considered to have apparent predictive power for these diseases.

Objective: To determine the predictive power of the ABSI for DMT2 and hypertension in Peru through the analysis of the Demographic and Health Survey-2020 (ENDES-by its acronym in Spanish-2020).

Methods: Cross-sectional analytical study of the ENDES-2020. The variables evaluated were ABSI, body mass index, high abdominal waist, waist-to-height ratio, body roundness index (BRI) and conicity index (COI). Areas under the curves (AUC) together with their 95% confidence interval (95%CI) were used to present each index.

Results: A total of 19 984 subjects were studied. Regarding hypertension, the highest AUC was presented by the COI: AUC=0.707 (95%CI 0.694-0.719). While the ABSI obtained the penultimate place: AUC=0.702 (95% CI 0.689-0.715). In case of DM2, the highest ABC was presented by BRI: AUC=0.716 (95%CI 0.689-0.743); while ABSI obtained the second place: AUC=0.687 (95%CI 0.658-0.717).

Conclusions: The results demonstrate that ABSI is not a good predictor for hypertension and DMT2 in the Peruvian population. If these findings are confirmed by other studies, its use would not be recommended for these diseases, and other anthropometric indicators that could perform better should be further explored.
Luskavica skozi prizmo prizadetosti srčno-žilnega sistema
Authors: Merzel Šabović Eva Klara , Starbek Zorko Mateja , Janić Miodrag
Published: November 2022

Luskavica je kronična sistemska vnetna bolezen. Sistemsko vnetje pri luskavici vodi v številne pridružene bolezni, med katerimi so srčno-žilne bolezni glavni vzrok obolevnosti in umrljivosti. Ker zaenkrat presejanje na prisotnost dejavnikov tveganja za srčno-žilne bolezni in njihova obravnava pri bolnikih z luskavico še vedno ni zadostno, je ključno ozaveščanje tako zdravnikov, ki bolnike z luskavico zdravijo, kot tudi samih bolnikov z luskavico. Bolnike z luskavico namreč lahko že v zgodnji starosti pomembno ogrožajo srčno-žilni zapleti. S člankom želimo povzeti ključna spoznanja o tem in podati okvirne usmeritve za obravnavo dejavnikov tveganja za srčno-žilne bolezni pri bolnikih z luskavico.
Liudviko Adomo Jucevičiaus mokslinių publicistinių darbų sudarymo principai
Authors: Burba Domininkas
Published: November 2022

Lietuvių raštijos veikėjo, katalikų dvasininko, vėliau palikusio kunigystę ir perėjusio į ortodoksinę krikščionybę, etnografo, tautosakininko, literato, publicisto, istoriko ir vertėjo Liudviko Adomo Jucevičiaus (Ludwik Adam Jucewicz) (1813–1846) gyvenimas ir kūryba mokslo pasaulyje yra plačiai tyrinėti, tačiau tikrai dar ne visos su šios asmenybės biografija susijusios temos yra atskleistos. Straipsnyje aiškinamasi, kaip buvo sudarinėjamos L. A. Jucevičiaus knygos. Tyrimo metu paaiškėjo, kad dalis autoriaus parengtų knygų, ypač pirmaisiais mokslinės veiklos metais, būdavo rašomos iškart ištisai. Tačiau vėlesni ir žymiausi jo veikalai būdavo spausdinami sujungus ir neretai praplėtus tekstus, publikuotus to meto periodinėje spaudoje, visų pirma Rusijos imperijos valdžiai lojalaus lenkų kalba ėjusio savaitraščio „Tygodnik Petersburski“ bei kitų leidinių puslapiuose. L. A. Jucevičiaus tekstai sulaukė populiarumo, jie būdavo perspausdinami Rusijos, Prūsijos ir Austrijos teritorijose lenkų kalba ėjusiuose periodiniuose leidiniuose, verčiami į rusų ir netgi vokiečių kalbas. Romantizmo epochos metu apolitiški L. A. Jucevičiaus tekstai mitologijos, tautosakos, etnografijos, istorijos temomis buvo priimtini tuo metu ėjusių žurnalų redakcijoms ne tik todėl, kad buvo palyginti brandūs, dėl jų negrėsė konfliktas su valdžia, bet ir dėl to, kad tuo metu lenkų kalba ėjusioje periodikoje trūko talentingų autorių darbų.
Rengimasis Santuokos sakramentui kaip sužadėtinių pasaulėžiūros nuostatų kaitos veiksnys
Authors: Advilonienė Živilė
Published: November 2022

Straipsnyje analizuojamas rengimasis Santuokos sakramentui kaip sužadėtinių pasaulėžiūros nuostatų kaitos veiksnys. Remiamasi Bažnyčios dokumentais, statistiniais duomenimis apie santuokų ir ištuokų kaitą Lietuvoje 1993–2021 m., bažnytinei santuokai besiruošiančių sužadėtinių patirtimis. Buvo atliktas tyrimas, skirtas nustatyti, kaip keitėsi pasirengimo santuokai kursus lankiusių sužadėtinių požiūris į šeimą, santuoką, lytiškumą ir tikėjimą kursų bei papildomų programų (savaitgalio rekolekcijų, katechezių, seminarų) metu. Tyrimas atskleidė, kad sužadėtinių požiūrio minėtais klausimais kaitą, taip pat jų santykio su tikėjimu ir Bažnyčia bei religinės praktikos pokyčius sąlygoja rengimosi bažnytinei santuokai kursuose gauta informacija, juose vykusios diskusijos su kursų vedėjais ir kviestiniais svečiais (medikais, dvasininkais, natūralaus šeimos planavimo mokytojais, sutuoktinių poromis), girdėti liudijimai, gilesnis Bažnyčios mokymo pažinimas, papildomos sužadėtiniams skirtos programos – savaitgalio rekolekcijos, katechezės, seminarai ir kt.
Oral health conditions of institutionalized older adults and associated factors
Authors: Silva Raul Anderson Domingues Alves da , Mendes Gemakson Mikael , Sousa Jéssica Soares de , Moura Walda Viana Brigido de , Regis Rômulo Rocha , Teixeira Ana Karine Macedo
Published: November 2022

Introduction: The growth of the Brazilian older adult population has influenced the increased demand for institutionalization for this public, which usually has poor oral health conditions such as edentulism. Objective: To characterize the oral health conditions and verify the variables related to the edentulism of institutionalized older adults and verify the relation of the time of institutionalization with oral health. Methods: It was a cross-sectional study conducted with 512 institutionalized older adults in which the sociodemographic profile, general health conditions, and oral health care and conditions were evaluated by clinical exams, consultations of medical records, and structured questionnaires. The data were analyzed in the Statistical Package for Social Sciences using the Pearson Chi-square and Fisher's Exact tests and a logistic regression model using a 95% confidence level. Results: A high DMFT (29.4), high prevalence of complete edentulism (61.3%), high need for maxillary (73.6%), and mandibular oral rehabilitation (56.8%) were observed. Edentulism was associated with older age (p<0.001), lower schooling (p<0.001) and non-retirement (p=0.031). It was found that longer institutionalization time remained associated with edentulism even when adjusted by sociodemographic and general health variables (p=0.013). It was also associated with the absence of brushing (p=0.024) and a lower frequency of tooth, gum, and prosthesis brushing (p<0.001). Conclusion: It is suggested to establish oral health care routines within long-term institutions for the effective maintenance of oral health throughout the institutionalization time.
Sintomas de impacto nutricional, sarcopenia e desnutrição em pacientes hospitalizados
Authors: Costa Talita Yoshimura da , Cristaldo Mara Rubia Areco , Marin Flávia Andréia , Spexoto Maria Claudia Bernardes
Published: November 2022

Introdução: Sintomas de impacto nutricional (SIN) são comuns em pacientes hospitalizados e estes podem ser agravados na presença da desnutrição. Objetivo: Verificar a presença de SIN e sua associação com as variáveis sociodemográficas, clínicas, fenótipo de sarcopenia e estado nutricional de indivíduos hospitalizados. Métodos: Trata-se de estudo transversal com pacientes internados, de ambos os sexos e idade ≥ 50 anos. Realizou-se Avaliação Subjetiva Global produzida pelo Paciente (ASG-PPP), força de preensão palmar (FPP), velocidade de caminhada (VC) e medidas antropométricas até 48 horas da admissão. Os SIN foram obtidos por meio da ASG-PPP e compilados em <3 ou ≥3 sintomas. Realizou-se o teste de qui-quadrado (χ2). Adotou-se nível de significância de 5%. Resultados: Um total de 90 pacientes (65,4±9,67 anos), sendo a maioria homem (56,7%), idoso (70,0%), casado (68,9%), classe econômica baixa (72,2%), sem atividade de trabalho (70,5%), com uma a duas doenças pregressas (60,0%), excesso de peso ao índice de massa corporal (46,7%) e adequada espessura do músculo adutor do polegar (83,3%). Os SIN “boca seca”, “anorexia” e “cheiros enjoam” foram os mais prevalentes, respectivamente 31,1%, 30,0% e 16,7%. Houve associação dos SIN com as variáveis que compõem o fenótipo de sarcopenia: o escore SARC-F (p=0,002) e FPP (p=0,016), status de sarcopenia (p=0,020), ASG-PPP (p<0,001) e classe econômica (p=0,020). Conclusão: A identificação de SIN é comum, podendo inferir negativamente no estado nutricional e desempenho funcional dos pacientes. Considerar o uso de protocolos para identificação dos SIN durante a hospitalização a fim de minimizar a repercussão negativa no estado nutricional.
Evaluation of film stimuli for the assessment of social-emotional processing: a pilot study
Authors: Leppanen Jenni , Patsalos Olivia , Surguladze Sophie , Kerr-Gaffney Jess , Williams Steven , Tchanturia Ketevan
Published: November 2022

Background

Difficulties in top-down and bottom-up emotion generation have been proposed to play a key role in the progression of psychiatric disorders. The aim of the current study was to develop more ecologically valid measures of top-down interpretation biases and bottom-up evoked emotional responses.

Methods

A total of 124 healthy female participants aged 18–25 took part in the study. We evaluated two sets of 18 brief film clips. The first set of film clips presented ambiguous social situations designed to examine interpretation biases. Participants provided written interpretations of each ambiguous film clip which were subjected to sentiment analysis. We compared the films in terms of the valence of participants interpretations. The second set of film clips presented neutral and emotionally provoking social scenarios designed to elicit subjective and facial emotional responses. While viewing these film clips participants mood ratings and facial affect were recorded and analysed using exploratory factor analyses.

Results

Most of the 18 ambiguous film clips were interpreted in the expected manner while still retaining some ambiguity. However, participants were more attuned to the negative cues in the ambiguous film clips and three film clips were identified as unambiguous. These films clips were deemed unsuitable for assessing interpretation bias. The exploratory factor analyses of participants’ mood ratings and evoked facial affect showed that the positive and negative emotionally provoking film clips formed their own factors as expected. However, there was substantial cross-loading of the neutral film clips when participants’ facial expression data was analysed.

Discussion

A subset of the film clips from the two tasks could be used to assess top-down interpretation biases and bottom-up evoked emotional responses. Ambiguous negatively valenced film clips should have more subtle negative cues to avoid ceiling effects and to ensure there is enough room for interpretation.
College Students' Ideological and Political Education and Cultural Self-Improvement in the Information Age with Detailed Discussions
Authors: Chenxu Wan
Published: November 2022

Practical exploration of college students' ideological and political education and cultural self-improvement in the information age is studied in this paper. The evaluation of traditional ideological and political education is more knowledge level, and the effect of such knowledge-based evaluation can hardly reflect the true It is difficult to reflect the effect of ideological and political education of the educated. It is undeniable that ideological and political education must first solve the problem of educated people's understanding of the content of specific ideological and political knowledge. Therefore, helping educated people "understand the truth" has become the basic goal of ideological and political education. Hence, this paper then gives the suggestions for the further applications of the general model. In the next stage of the study, we will consider the different scenarios.
Challenges Faced by Ideological and Political Education in the Era of Big Data and the Solution Discussions
Authors: Chenxu Wan
Published: November 2022

Problems and solutions faced by ideological and political education in the era of big data is the key topic of this paper. Big data is widely used in our country. It can be said that there are big data in all walks of life,hence, we consider the combinational model. The ideological and political education environment is the sum of all external factors that have the positive or negative impact on the ideological and political education activities organized by educators and the formation and development of educated people's ideology and morality, and this paper gives the novel solutions faced by ideological and political education in the era of big data.
Pattern of Neonatal Admissions and Care Outcomes in Special Care Newborn Unit of Cox’s Bazar District Hospital, Bangladesh
Authors: Oladeji Olusola , Zaman Md. Shamsuz , Alam Mohammad Sazzadul , Sayeed K. M. Ishtiaque , Oladeji Anjola , Rana Rayhan Uddin , Paul Liza , Widiati Yulia
Published: November 2022

Background: Neonatal morbidity and mortality contribute significantly to under‑five morbidity and mortality. A substantial reduction in neonatal mortality is therefore necessary to achieve the Sustainable Development Goals targets.

Aims: Assessed the pattern of neonatal admission and care outcomes.

Place and Duration of Study: Special Care Newborn Unit of Cox’s Bazar District hospital, Bangladesh conducted in September 2022.

Methodology: Hospital-based retrospective study. Data extracted from the admission register and the records of 3982 newborns admitted between August 2021 and July 2022. Bivariate analysis using the Chi-square test, was performed to determine factors associated with neonatal mortality and p value was set at significant level of 5%.

Results: 3982 neonates were admitted, 2426 (61%) were male and 1556 (39%) were female with1071 (27%) from the hospital and 2911(73%) from outside the hospital. Birth asphyxia was the commonest morbidity,49% followed by Low Birth Weight/prematurity (18%) and neonatal sepsis 17%. 3,225 (81.4%) of the neonates admitted survived while 538 (13.5%) died and 203(5.1%) were discharged against medical advice. There was significant association between birth weight, morbidity pattern and mortality p<0.05) with most deaths associated with prematurity/LBW. There was significant association between neonatal mortality and the place of delivery, death among outborn was 16% compared with 7% among inborn (p<0.05) but no significant association between neonatal mortality and gender.

Conclusion: There was a high burden of neonatal care at the hospital and majority of causes of neonatal morbidity and mortality were preventable. There is need for holistic approach to pregnancy, delivery and newborn care to reduce neonatal morbidity and mortality in the district.
A Test to Measure the Knowledge Level of Cardamom Growers about the Eco-Friendly Cultivation Practices from a Study Carried Out in the State of Kerala, India
Authors: Baby Amanda , Sailaja V. , Reddy P. Bala Hussain , Chandrika V.
Published: November 2022

The present study contemplates to construct a knowledge test to measure the knowledge level of cardamom growers with regards to various eco-friendly cultivation practices in cardamom. Ex- post facto research design was used for the study. Kerala state was chosen as the locale of the study. . Ex-post facto research design is widely used in social as well as behavioral sciences. It has strong points that make it the most appropriate research design in a number of circumstances as well as limitations that make it weak from the point of view of its internal and external validity. The study was conducted in the year 2021. The study was carried out in two taluks namely Udumbanchola and Devikulam of Idukki district as cardamom crop is grown extensively here. The knowledge test was conducted outside the sample area. The content of the test was composed of questions called items. The test consists of 65 items and can be applied to the cardamom growers. Finally after the knowledge test 37 items were selected and included in the interview schedule. Scientific knowledge about eco-friendly cultivation practices is very much important for enhancing the organic cardamom production. Out of 65 items 37 were selected to measure the knowledge level of eco-friendly cardamom growers. Overall knowledge was measured by using a knowledge test comprising of these 37 items.
Comparative Analysis on Impact of Different Mulches on Growth and Yield Parameters of Mulberry under Rainfed Condition of Poonch District of Jammu and Kashmir
Authors: Chanotra Suraksha , Thakur Priyanka , Bhat Muzafar Ahmad , Angotra Jyoty , Verma Gurvinder Raj , Aziz Abdul
Published: November 2022

The current study was formulated to analyse the impact of different biodegradable and synthetic mulches on growth and yield parameters of mulberry plant. Among the selected parameters survival rate of mulberry plants was recorded to be maximum in T-2 i.e, paddy straw and husk as 95% followed by T-1 and T-3 i.e, Black polythene mulch and Green branches of tree respectively as 90% and least for Control i.e, without any mulch as 70%. Least population of weeds with minimum intensity was recorded in T-1 (05) followed by T-2 (08) and T-3 (10). Maximum weed flora with highest intensity of weeds was found in Control i.e, without any mulch (20). For the studied samples, maximum soil moisture percentage and moisture retention capacity (MRC) of 66.57 & 95.6% was recorded in T-1 followed by T-3 as 40.31 & 87% and T-2 as 16.36 & 91% and minimum in control as 13.43 & 85.56%. The pH was recorded as 6.1 in T-1 depicting the slightly acidic soiland could be viewed as the most appropriate soil pH for mulberry cultivation. Available NPK were recorded to be in the most ideal range for T-1 as 8.2, 1.3 and 9.6%. Maximum leaf size was recorded in T-1 as 126cm followed by T-2 and T-3 as 116cm and 110cm respectively and 105cm in control. Moisture percentage was recorded to be highest 76.23% followed by 74.61% and 54.16% for T-3, T-1 and T-2 respectively and 68.2% in control. Maximum MRC was observed in case of plants grown under Black polythene mulch (73.24%) and least in green branch mulch (61.39%). Therefore, it can be concluded that application of suitable bio-mulches in mulberry fields can reduce the dependency of chemical weedicides.
In vitro Evaluation and Molecular Docking Analysis of Potential Anticancer Compounds from Syzygium alternifolium
Authors: Madhuri M. Lakshmi , Reddy R. Raja
Published: November 2022

Around the world, Syzygium alternifolium is widely distributed in tropical and subtropical areas. This plant has traditionally been used to treat a variety of illnesses, including cancer. The current research compared the standard drug doxorubicin to the anticancer activity of methanolic extract of Syzygium alternifolium bark on human hepatocyte carcinoma (HepG2) cell line. Through DNA intercalation, inhibition of topoisomerase-II-mediated DNA repair, free radical production and consequent damage to cellular membranes, DNA, and proteins, doxorubicin exerts its anticancer activity in cancerous cells. Research on cytotoxicity have shown that Syzygium alternifolium phytoconstituents can selectively target cancer cells (IC50 = 185.585 µg/ml), while having little to no cytotoxic effects on normal cells Using Mcule docking software, molecular docking studies were performed against the human Topoisomerase-2 and CDK-2 proteins (Protein Data Bank-ID: 1ZXM and 1DI8, respectively). Seven compounds from the bioactives isolated are considered as safe inhibitors, according to in silico studies. In order to better understand the probable mechanisms of action and create more efficient and cost-effective therapies, molecular docking experiments were carried out employing phytoconstituents. This study demonstrates a significant consistency of anticancer therapeutic drug potentials of Syzygium alternifolium by in vitro and in silico approaches, leading the way for a better understanding of how integrating molecular docking and in vitro studies can improve the identification of cancer drugs.
Diallel Analysis for Yield and Quality Characteristics in Melon
Authors: Melgoza Francisco Alfonso Gordillo , Escalante Fernando Borrego , Río Alejandro Javier Lozano del , Benítez Alfonso López , Mendoza Adalberto Benavides , Torres Norma Angélica Ruiz , Martínez Rosendo Hernández , Aranda Cristina Patricia Aguilar
Published: November 2022

Aims: To estimate the effects of general and specific combinatorial fitness in parents and progeny on yield and fruit quality related traits of melon.

Study Design: A completely randomized block design with three replications was used to estimate the analysis of variance and the effects of general combining ability (GCA) and specific combining ability (SCA). The genetic analysis was carried out based on the Griffing Method II dialelic design (1956) with fixed effects model. Tukey P=.05 mean comparison analysis.

Place and Duration of Study: The research was conducted in two stages. In stage 1, seed production of the parents and crosses was carried out at the Physiotechnical Greenhouse of the of the Universidad Autónoma Agraria Antonio Narro, Saltillo, Coahuila. Mexico, between April and July 2021. In stage 2, the evaluation of the parents and progeny was carried out between August and November 2021 in the agricultural field "La Jaroza", Paila, Coahuila. México.

Methodology: In the present study, seven melon parents were analyzed. The parents were crossed in all possible combinations, without reciprocal crosses, resulting in 21 progenies, a total of 28 genotypes evaluated.

Results: The results showed significant differences between genotypes, general and specific combining ability effects (GCA and SCA) for almost all variables, except fruit number. The parent "(E x L)" showed the best yield and GCA effects, and participated in most of the outstanding crosses in yield, average fruit weight, fruit length, fruit width, flesh thickness, seed cavity and soluble solids. The "N x (E x L)" progeny excelled in yield and average fruit weight in SCA.

Conclusion: The parent "(E x L)" showed the best yield and GCA effects and participated in most of the outstanding crosses in yield, average fruit weight, fruit length, fruit width, flesh thickness, seed cavity and soluble solids. The progeny "N x (E x L)" excelled in yield in SCA.
Mobile zinc as a modulator of sensory perception
Authors: Goldberg Jacob M. , Lippard Stephen J.
Published: November 2022

Mobile zinc is an abundant transition metal ion in the central nervous system, with pools of divalent zinc accumulating in regions of the brain engaged in sensory perception and memory formation. Here, we present essential tools that we developed to interrogate the role(s) of mobile zinc in these processes. Most important are (a) fluorescent sensors that report the presence of mobile zinc and (b) fast, Zn‐selective chelating agents for measuring zinc flux in animal tissue and live animals. The results of our studies, conducted in collaboration with neuroscientist experts, are presented for sensory organs involved in hearing, smell, vision, and learning and memory. A general principle emerging from these studies is that the function of mobile zinc in all cases appears to be downregulation of the amplitude of the response following overstimulation of the respective sensory organs. Possible consequences affecting human behavior are presented for future investigations in collaboration with interested behavioral scientists.
Time‐dependent effects of hypoxia on cell metabolism, signaling, and iron homeostasis in the hematopoietic progenitor model KG1a
Authors: Nahoui‐Zarouri Inès , Léger Claire , El Samra Ghina , Cottet‐Rousselle Cécile , Moulis Jean‐Marc
Published: November 2022

Lowered availability of oxygen in the micro‐environment of cells perturbs metabolic and signaling pathways. It affects proliferation, tissue morphology, and differentiation. Leukemia impairs maturation of hematopoietic progenitors: the immune system, healing, and erythropoiesis are weakened, thereby perturbing iron homeostasis and further lowering oxygen provision to tissues. Here, the time‐dependent molecular consequences of sudden hypoxia were studied in the KG1a model of immature hematopoietic progenitors. The oxygen tension of KG1a cells was abruptly lowered from the experimentally usual ca. 20 to 1%. Growth and key hubs of signaling, metabolism, and iron homeostasis were monitored by a combination of immunological methods and functional assays. The collapse of oxygen availability stopped proliferation after one generation. The number of cells then remained approximately constant over several days, including after anaerobic changes in the culture medium. Lowered oxygen resulted in transient increase of the hypoxia‐inducible factor 1α and of its REDD1 target, inhibition of mechanistic (or mammalian) target of rapamycin, decreased autophagy, altered cap‐dependent translation, and minimal repression of the already weak oxidative phosphorylation. These adjustments did not trigger important cellular iron fluxes since the cells relied on their internal iron stores to survive. In conclusion, the response of the KG1a cells to stringent hypoxia is varied, with some established hypoxia‐sensitive pathways exhibiting activation whereas others were unaffected. The results draw attention to the flexibility of the environmental adaptation of cancer cells. They suggest that thorough characterization of early leukemic blasts is warranted to propose informed treatments to patients.
Plasmon‐Assisted Self‐Encrypted All‐Optical Memory
Authors: Zhang Chengyun , Ji Min , Zhou Xilin , Mi Xiaohu , Chen Huan , Zhang Baobao , Fu Zhengkun , Zhang Zhenglong , Zheng Hairong
Published: November 2022

All‐optical responsive nanomaterials, which can rapidly switch between two stable states, have been regarded as the next‐generation memories due to their potential to realize binary information storage and implement on‐chip, integrated photonic neuromorphic systems. Rare earth oxides are preeminent candidates owing to their extraordinary luminescent stability and narrow optical transitions. However, due to the lack of simple and effective optical switches, it is difficult to realize all‐optical data storage, encoding, and retrieval by pure rare earth‐doped luminescent nanoparticles. Here, a rapid and high‐contrast of 104 luminescent switching of Y2O3:Eu3+ nanoparticle between the enhancement and quenching states is achieved by employing the strong light confinement and ultrafast thermal response of localized surface plasmon resonance. A self‐encrypted all‐optical memory is presented with optical information writing, encryption, reading, and re‐writing, and a high‐sensitivity synaptic response of emitters to frequency and light intensity flux, which can be harnessed to encrypt information flows and promote convenient and high‐security information encryption. Such a convenient and secure plasmonic thermally assisted self‐encrypting luminescent switch paves the way for constructing high‐performance stimuli‐responsive rare earth oxide crystals on demand and expanding their applications in various data encryption, anti‐counterfeiting, and rewritable colouration devices.
Basic Alkylamine Functionalized PAF‐1 Hybrid Membrane with High Compatibility for Superior CO2 Separation from Flue Gas
Authors: Zhang Panpan , Zhang Chi , Wang Lei , Dong Junchao , Gai Dongxu , Wang Wenjian , Nguyen Thien S. , Yavuz Cafer T. , Zou Xiaoqin , Zhu Guangshan
Published: November 2022

Functionalized porous aromatic frameworks (PAFs) are excellent candidate materials for hybrid membrane fabrication. However, tailoring PAFs for membrane CO2 separation with desirable performance is still a challenge. Here, facile fabrication of functional hybrid alkylamine‐modified PAF‐1 containing membranes with high compatibility for efficient CO2/N2 separation is reported. The methylamino groups are installed on PAF‐1 resulting in PAF‐1‐CH2NH2 that has a high surface area of over 1400 m2 g–1 and unique CO2 adsorption with CO2/N2 thermodynamic selectivity of over 1000. Amidation reaction is developed for PAF‐1‐CH2NH2 cross linking with cPIM‐1 (carboxylic polymer of intrinsic microporosity), giving a homogenous compatible membrane of PAF‐1‐CH2NH2—cPIM‐1 with outstanding CO2 permeability (≈10790 Barrer) and high CO2/N2 permselectivity (≈43). This membrane outperforms the counterparts derived from parent PAF‐1 and phenylamine PAF‐1 and possesses superior performance to other relevant membranes for CO2/N2 separation. Such a membrane can selectively and stably separate CO2 from N2 in a simulated flue gas mixture, demonstrating its huge potential in carbon capture.
3D‐Printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Delivery
Authors: Chang Tien‐Jen , Kjeldsen Rolf Bech , Christfort Juliane Fjelrad , Vila Eduard Marzo , Alstrøm Tommy Sonne , Zór Kinga , Hwu En‐Te , Nielsen Line Hagner , Boisen Anja
Published: November 2022

During the past decades, microdevices have been evaluated as a means to overcome challenges within oral drug delivery, thus improving bioavailability. Fabrication of microdevices is often limited to planar or simple 3D designs. Therefore, this work explores how microscale stereolithography 3D printing can be used to fabricate radiopaque microcontainers with enhanced mucoadhesive geometries, which can enhance bioavailability by increasing gastrointestinal retention. Ex vivo force measurements suggest increased mucoadhesion of microcontainers with adhering features, such as pillars and arrows, compared to a neutral design. In vivo studies, utilizing planar X‐ray imaging, show the time‐dependent gastrointestinal location of microcontainers, whereas computed tomography scanning and cryogenic scanning electron microscopy reveal information about their spatial dynamics and mucosal interactions, respectively. For the first time, the effect of 3D microdevice modifications on gastrointestinal retention is traced in vivo, and the applied methods provide a much‐needed approach for investigating the impact of device design on gastrointestinal retention.
Topology and Symmetry in Quantum Materials
Authors: Singh Bahadur , Lin Hsin , Bansil Arun
Published: November 2022

Interest in topological materials continues to grow unabated in view of their conceptual novelties as well as their potential as platforms for transformational new technologies. Electronic states in a topological material are robust against perturbations and support unconventional electromagnetic responses. The first‐principles band‐theory paradigm has been a key player in the field by providing successful prediction of many new classes of topological materials. This perspective presents a cross section through the recent work on understanding the role of geometry and topology in generating topological states and their responses to external stimuli, and as a basis for connecting theory and experiment within the band theory framework. In this work, effective strategies for topological materials discovery and impactful directions for future topological materials research are also commented.
Flexible and Transparent Flexoelectric Microphone
Authors: Shehzad Mudassar , Wang Yaojin
Published: November 2022

PVDF based flexoelectric polymers imply innumerous applications, for example, in developing flexible and transparent transducers for touch screen users. Here, a prototype flexoelectric microphone is developed and characterized. A straightforward method is adopted to fabricate the microphone device in which a film of copolymer blend is sandwiched between pair of ITO coated transparent electrodes integrated at the stretched rubber substrates. In this study, the phase represented at 1337 cm−1 of FTIR reflection spectra containing 50% α and 50% ß termed as Zeta phase which is correlated to the enhancement in its flexoelectric properties, is investigated. Here, the flexoelectric coefficient (µ33) and sensitivity (S) of 6.5 cm × 5 cm flexible and transparent laminates featuring 0 ≤ φ ≤ 1.0 blends at 100SPL is examined. The study reports the µ33 = 23.5 µC m−1 and S = 15.3 V Pa−1 for φ = 0.5 blend, which is the highest reported values for P (VDF‐TrFE) and P (VDF‐TrFE‐CTFE) polymer blends. This study is helpful in developing the flexible and transparent flexoelectric microphones for potential mobile applications.
NIR Laser Integration of Photodetector on 3D Printed Chamber for Colorimetric Biosensing
Authors: Lin Ching‐Fu , Chang Chun‐Hao , Noël Laurent , Li Bor‐Ran , Meng Hsin‐Fei , Soppera Olivier , Zan Hsiao‐Wen
Published: November 2022

In this work, gold nanoparticles (Au NPs)/indium‐zinc‐oxide (IZO) nanocomposite visible photodetector (PD) is directly prepared by near‐infrared (NIR) laser‐annealing on a 3D‐printed substrate to form an integrated colorimetric sensor. After a surface planarization process, using a low power laser treatment without damaging the substrate, Au NPs are formed from the Au thin layer (6 nm) on 3D‐printed resin substrate by laser‐assisted dewetting process. Also, the UV–vis photoresponsivity is compared by tuning different NIR laser power intensity for sol‐gel IZO curing. By investigating the temperature profile of each laser annealing process and the surface morphology of Au NPs/IZO nanocomposite film, the optimized PD is then integrated with a 3D‐printed sensing chamber for successfully demonstrating urea detection varied from 1, 5, 10, 25 and 50 × 10−3 m, which refer to the salivary urea concentrations for healthy and chronic kidney disease groups.
In Situ Process Monitoring and Multichannel Imaging for Vacuum‐Assisted Growth Control of Inkjet‐Printed and Blade‐Coated Perovskite Thin‐Films
Authors: Schackmar Fabian , Laufer Felix , Singh Roja , Farag Ahmed , Eggers Helge , Gharibzadeh Saba , Abdollahi Nejand Bahram , Lemmer Uli , Hernandez‐Sosa Gerardo , Paetzold Ulrich W.
Published: November 2022

Vacuum‐assisted growth (VAG) control is one of the most promising methods for controlling nucleation and crystallization of printed and coated large area lead halide perovskite‐based layers for optoelectronics. To coat or print homogeneous high‐quality perovskite thin‐films at high fabrication yield, real‐time process monitoring of the VAG is pivotal. In response, a 2.1‐megapixel multichannel photoluminescence (PL) and reflection imaging system is developed and employed for the simultaneous spatial in situ analysis of drying, nucleation, and crystal growth during VAG and subsequent thermal annealing of inkjet‐printed and blade‐coated perovskite thin‐films. It is shown that the VAG process, for example, evacuation rate and time, affects the film formation and provide detailed insight into traced PL and reflection transients extracted from sub‐second videos of each channel. Based on correlative analysis between the transients and, for example, perovskite ink composition, wet‐film thickness, or evacuation time, key regions which influence crystal quality, film morphology, and are base for prediction of solar cell performance are identified.
Plastically Bendable Organic Crystals for Monolithic and Hybrid Micro‐Optical Circuits
Authors: Ravi Jada , Feiler Torvid , Mondal Amit , Michalchuk Adam A. L. , Reddy C. Malla , Bhattacharya Biswajit , Emmerling Franziska , Chandrasekar Rajadurai
Published: November 2022

Fluorescent plastically bendable crystals are a promising alternative to silicon‐based materials for fabricating photonic integrated circuits, owing to their optical attributes and mechanical compliance. Mechanically bendable plastic organic crystals are rare. Their formation requires anisotropic intermolecular interactions and slip planes in the crystal lattice. This work presents three fluorescent plastically bendable crystalline materials namely, 2‐((E)‐(6‐methylpyridin‐2‐ylimino)methyl)‐4‐chlorophenol (SB1), 2‐((E)‐(6‐methylpyridin‐2‐ylimino)methyl)‐4‐bromophenol (SB2), and 2‐((E)‐(6‐Bromopyridin‐2‐ylimino)methyl)‐4‐bromophenol (SB3) molecules. The crystal plasticity in response to mechanical stress facilitates the fabrication of various monolithic and hybrid (with a tip‐to‐tip coupling) photonic circuits using mechanical micromanipulation with an atomic force microscope cantilever tip. These plastically bendable crystals act as active (self‐guiding of fluorescence) and passive waveguides both in straight and extremely bent (U‐, J‐, and O‐shaped) geometries. These microcircuits use active and passive waveguiding principles and reabsorbance and energy‐transfer mechanisms for their operation, allowing input‐selective and direction‐specific signal transduction.
Spin‐Orbit Modal Optical Vortex Beam Shaping from Dielectric Metasurfaces
Authors: Jin Mingke , Sanchez‐Padilla Benjamin , Liu Xuan , Tang Yutao , Hu Zixian , Li Kingfai , Coursault Delphine , Li Guixin , Brasselet Etienne
Published: November 2022

Optical information and communication technologies are essentially based on the ability to shape the light field, either at the transmission or at the reception of the optical signal. Nowadays, wavelength and polarization state are already implemented in current telecom architectures and adding the spatial structuring of the light field as a novel degree of freedom to enhance data rate is desirable. In this context, the development of optical devices to shape optical modes belonging to orthogonal basis remains challenging. Here, in the context of singular optics, this work reports on the design, fabrication, and characterization of modal optical vortex beam shaping of paraxial light in the visible domain, in the framework of the Laguerre–Gauss basis. Both the azimuthal and radial degrees of freedom are univocally shaped via optical spin‐orbit interaction mediated by dielectric metasurfaces by combining the spatial modulation of amplitude, geometric phase, and dynamic phase. These results not only demonstrate the realization of new optical components, but also highlight how metasurface‐based technologies can contribute to optical information processing in the classical or quantum regime.
Manipulation of Fractal Nano‐Kirigami by Capillary and Electrostatic Forces
Authors: Hong Xiaorong , Liang Qinghua , Liu Xing , Ji Chang‐Yin , Li Jiafang
Published: November 2022

Fractals are beautiful forms of geometric patterns, usually having high degrees of freedom of shape change. Recently, fractal and fractal‐like designs have aroused great interest in scientific research. Here, fractal‐like nano‐kirigami structures with rotational symmetries are proposed and demonstrated, in which topological morphologies can be transformed by growing fans and coiling units. Experimentally, the nano‐kirigami structures with different fractals are manipulated by using the capillary force‐induced 3D deformation process. Benefited from the fractal‐like designs, the structral deformations exhibit strong fractal dependence, with which the stress threshold and reflection spectrum can be tailored by changing the number of fans and coiling units. The modulation of fractal nano‐kirigami is further demonstrated by using the electrostatic forces when external voltage is applied. The fractal nano‐kirigami structures are also envisioned with capability of conveniently generating fractal‐dependent optical vortices. The special fractal design strategy in this work can bring new opportunities to functional 3D micro/nano structures with improved optical tunability and customization.
A Novel In Vitro Disease Model for Systemic Sclerosis Using Polyisocyanide Hydrogels
Authors: Kumari Jyoti , Wubs Tirza , van Caam Arjan P.M. , Dorst Daphne N. , Wagener Frank A. D. T. G. , Kouwer Paul H. J.
Published: November 2022

Systemic sclerosis (SSc) is a rare autoimmune disease with limited treatment options that is characterized by fibrosis in various organs. To screen the effectiveness of new therapies, there is an urgent need for reliable in vitro models. Key is that diseased cells' characteristics are maintained, which is challenging in currently used setups. In this study, an in vitro 3D culture system is described using the biocompatible polyisocyanide (PIC‐RGD) hydrogel and SSc patient‐derived fibroblasts from affected (lesional cells) and from healthy‐skin (healthy cells). In contrast to the standard collagen‐coated 2D cultures, the cells in the 3D PIC‐RGD gels maintain the native phenotype and functionality of the primary cells. The functionality of the model is studied in the presence of the fibrosis stimulator transforming growth factor β1 (TGFβ1) and the suppressor tumor necrosis factor (TNFα). In this study, it is observed that lesional cells have a stronger fibrotic character with increased contraction, proliferation, and expression of collagen, and myofibroblast markers α‐smooth muscle actin and fibroblast activation protein. The high tunability of the hydrogel, which can maintain the native functionality of fibroblasts in in vitro cultures, delivers a crucial step in developing these materials into an effective tool for personalized medicine approaches of SSc patients.
Multifunctional Superparticles for Magnetically Targeted NIR‐II Imaging and Photodynamic Therapy
Authors: Liu Yilin , Liang Yuan , Lei Pengpeng , Zhang Zhen , Chen Yongming
Published: November 2022

Theranostics, the combination of diagnostics and therapies, has been considered as a promising strategy for clinical cancer treatment. Nonetheless, building a smart theranostic system with multifunction for different on‐demand applications still remains elusive. Herein, an easy and user‐friendly microemulsion based method is developed to modularly assemble upconversion nanoparticles (UCNPs) and Fe3O4 nanoparticles together, forming multifunctional UCNPs/Fe3O4 superparticles with highly integrated functionalities including the 808 nm excitation for real‐time NIR‐II imaging, magnetic targeting, and the upconversion luminescence upon 980 nm excitation for on‐demand photodynamic therapy (PDT). With a magnet placed nearby the tumor, in vivo NIR‐II imaging uncovers that superparticles tend to migrate toward the tumor and exhibit intense tumor accumulation, ≈6 folds higher than that without magnetic targeting 2 h after intravenous injection. NIR laser irradiation is then used to trigger PDT, obtaining an outstanding tumor elimination under magnetic tumor targeting, which shows a high potential to be applied in targeted cancer theranostics.