bluuebunny/crossref_metadata_2025 huggingface dataset:
Imágenes de la otredad. Arte, política y cuerpos residuales en Daniel Santoro
Authors: Ruiz Laura
Published: October 2019

En este artículo se analiza la obra pictórica de Daniel Santoro con el fin de examinar el relato de determinados cuadros en particular y de todos ellos como serie. Se tomaen consideración el cuerpo social y político representado para analizar la socialización delconcepto de creación en el ida y vuelta entre la historia, la sociedad y el artista. En estaarticulación se analiza, en el discurso visual, la irrupción de lo otro como barbarie, comoexceso o como cuerpos residuales. Esta intrusión opera para desmontar una naturalizadaarmonía preexistente en un mundo político y simbólico en el que lo reprimido regresacomo mito. Los relatos pictóricos ponen una forma o un estado nostálgico del pasado y debúsqueda de lo perdido, no a modo de lamento sino de propuesta de lucha por deshaceruna imagen y presentar otra en la escala de valores imaginativos.
Stereoacuity in preschool children – could the Randot stereotestbe the screening test to prevent amblyopia?
Authors: Muskalska Anita , Chlasta-Twardzik Edyta , Sędziak-Marcinek Bogumiła , Krok Magdalena , Pojda-Wilczek Dorota
Published: October 2019

Wstęp

Zaburzenia rozwoju widzenia (niedowidzenie) mogą wynikać z zaburzeń refrakcji, wad wzroku, zeza, deformacji
gałki ocznej lub przeszkód w ośrodkach optycznych (np. zaćma). Niedowidzenie u dzieci w wieku przedszkolnym
może prowadzić do nieprawidłowości w rozwoju psychoruchowym. Jego wczesne wykrycie daje szansę na leczenie
i prawidłowy rozwój dziecka.

Materiał i metody

Pierwszą część badania przeprowadzono za pomocą Testu Randota. Druga część badania polegała na ułożeniu przez dzieci jak najwyższej wieży zbudowanej z drewnianych klocków. Przebadano 412 dziewczynek i 398 chłopców w wieku od 3 do 7 lat. W przypadku braku widzenia stereoskopowego dzieci zostały skierowane na badanie okulistyczne. Statystyka przeprowadzona została za pomocą testów dla trendu Cochran-Armitage i Jonckheere-Terpstry przy użyciu oprogramowania MedCalc i SPSS 17.0.

Wyniki

U 18 (2,2%) dzieci stereopsji nie stwierdzono. Najwięcej dzieci osiągnęło głębię widzenia na poziomie 100 sekund kątowych: 76% 3-latków, 46% 4-latków i 60% 5-latków. Wśród starszych dzieci największa grupa osiągnęła poziom stereopsji na poziomie 70 sekund kątowych (43% 6-latków i 53% 7-latków). Wieżę z klocków prawidłowo ustawiły
wszystkie dzieci (100%). Poziom stereopsji zwiększał się z wiekiem istotnie statystycznie. U dzieci bez widzenia
stereoskopowego stwierdzono niedowidzenie jedno- lub obuoczne z powodu wad refrakcji.

Wnioski

Test Randota okazał się skutecznym narzędziem w wykrywaniu zaburzeń widzenia obuocznego u dzieci przedszkolnych. Autorki sugerują wprowadzenie Testu Randota jako uzupełnienie badania przesiewowego w wykrywaniu niedowidzenia u dzieci przedszkolnych.
DHEAS/CORTISOL INDEX AS A MARKER OF STRESS-INDUCED PREMATURE AGING
Authors: Kovyazina N. A. , Alhutova N. A.
Published: October 2019

The detection of stress-induced premature aging with the aim of correcting damaging adaptive effects seems to be actual today. The article discusses the use of the DHEAS / cortisol index as a screening marker for accelerating the rate of biological aging in people exposed to stress.
NÚMERO COMPLETO
Authors: Palabra La
Published: October 2019

NÚMERO COMPLETO
A 4-choosable graph that is not (8:2)-choosable
Authors: Dvořák Zdeněk , Hu Xiaolan , Sereni Jean-Sébastien
Published: October 2019

List coloring is a generalization of graph coloring introduced by Erdős, Rubin and Taylor in 1980, which has become extensively studied in graph theory. A graph G is said to be k-choosable, or k-list-colorable, if, for every way of assigning a list (set) of k colors to each vertex of G, it is possible to choose a color from each list in such a way that no two neighboring vertices receive the same color. Note that if the lists are all the same, then this is asking for G to have chromatic number at most k.

One might think that the case where all the lists are the same would be the hardest: surely making the lists different should make it easier to ensure that neighboring vertices have different colors. Rather surprisingly, however, this is not the case. A counterexample is provided by the complete bipartite graph K2,4. If the two vertices in the first vertex class are assigned the lists {a,b} and {c,d}, while the vertices in the other vertex class are assigned the lists {a,c}, {a,d}, {b,c} and {b,d}, then it is easy to check that it is not possible to obtain a proper coloring from these lists, so G is not 2-choosable, and yet the chromatic number of G is 2. A famous theorem of Galvin, which solved the so-called Dinitz conjecture, states that the line graph of the complete bipartite graph Kn,n is n-choosable. Equivalently, if each square of an n×n grid is assigned a list of n colors, it is possible to choose a color from each list in such a way that no color appears more than once in any row or column.

One can generalize this notion by requiring a choice of not just one color from each list, but some larger number of colors. A graph G is said to be (A,B)-list-colorable if, for every assignment of lists to the vertices of G, each consisting of A colors, there is an assignment of sets of B colors to the vertices such that each vertex is assigned a set that is a subset of its list and the sets assigned to pairs of adjacent vertices are disjoint. (When B=1 this simply says that G is A-choosable.) In this short paper, the authors answer a question that has remained open for almost four decades since it was posed by Erdős, Rubin and Taylor in their seminal paper: if a graph is (A,B)-list-colorable, is it true that it is also (mA,mB)-list-colorable for every m≥1? Quite surprisingly, the answer is again negative - the authors construct a graph that is (4,1)-list-colorable but not (8,2)-list-colorable.
The role of collocations in the formation of the lexical speech skills
Authors: Aksenova Inga
Published: October 2019

The main goal of teaching foreign language is the formation of foreign language communicative competence which implies the development of speech skills. In the methods there are different approaches to teaching foreign language, one of which is the lexical approach. Undoubtedly, the lexical approach involves focus on learning the vocabulary of the language. However, there are different points of view on which methods and forms of work are the most effective ones. Mastering vocabulary occurs by studying the compatibility of words, phrases and combinations of words. Collocations are an isolated concept, meaning certain words in a language that tend to be used together. Working with collocations is an essential component of the lexical skills formation, accordingly, we should speak about the inclusion of collocational competence in communicative competence. Analysis of the methodic literature showed that the issue of the collocations’ role in the lexical speech skills formation is not very disclosed in the domestic and foreign methodic literature. In the presented article: 1) we conduct an analysis of the works of domestic and foreign scientists on the lexical approach in teaching foreign language; 2) we prove that the process of learning vocabulary goes by learning certain combinations of words and the ability to use them;
3) we derive the definition of collocations based on the definitions and classifications of scientists; 4) we determine the key place of collocations in the vocabulary learning.
Methodical model for teaching foreign professional communication students of “Agricultural Engineering” programme based on content and language integrated learning
Authors: Baydikova Tatiana
Published: October 2019

Methodical model is a set of interconnected components that form a single system aimed at achieving a common goal – the formation of foreign language communicative competence among students in the “Agricultural Engineering” programme based on content and language integrated learning. The teaching system is built on the basis of system, competency-based, per-sonal-activity, communicative-cognitive approaches, as well as content and language integrated learning. These approaches are implemented in practice using a number of didactic and methodical principles. We describe in detail the methodical principles of content and language integrated learning: principle 4 “C”, the principle of cognition, the principle of unity of thought and speech activity, the principle of integration of a foreign language and subject content, the principle of gradual complication of content, the principle of duality of reliance on native and foreign lan-guages, the principle of optimality, the principle of knowledge personalization, the principle of in-teractivity and the principle of language adaptation. Content and language integrated learning of students is carried out on the basis of the following teaching methods: interactive, communicative, information-reproductive, productive, tandem-method, vocational teaching and control methods. The content of teaching based on content and language integrated modeling reflects the profile specifics of training specialists in the framework of a particular specialty. Learning tools are a set of tools of a teacher for the purpose of development, teaching and upbringing. We present and de-scribe in detail all the components of the methodical model.
Model of continuing pedagogical education in the region: implementation experience and development prospects
Authors: Gushchina Tatyana , Makarova Lyudmila , Kurin Andrey
Published: October 2019

We substantiate the necessity of developing and implementing an innovative model of continuous pedagogical education in the region. As such model, we consider a multilevel educa-tional complex, created on the basis of the Pedagogical Institute of Derzhavin Tambov State Uni-versity, whose activities are aimed at implementing a number of federal projects in the framework of the national project “Education”. Our position is that the developed complex has a number of undoubted advantages in comparison with isolated educational institutions that train personnel and is able to effectively resolve existing problems in the continuous pedagogical education of the region. We substantiate the structure of a multilevel educational complex, which is a hierarchy of stages, in which the previous stage sequentially ensures the functioning of the subsequent ones. Each of the five levels (preschool education, pre-vocational pedagogical training, secondary voca-tional education, higher and postgraduate education) is described in detail: the basic mechanisms of their functioning are examined, the existing experience of implementation is analyzed, and pro-spects for further development are presented. We determine the results of educational complex of continuing pedagogical education influence on the development of the Tambov Region.
The issue of diagnostics of educational design efficiency of younger students’ communication
Authors: Voropaev Mikhail , Kuchkareva Svetlana
Published: October 2019

We consider the concept of educational design as a tool that allows students to control communication. The second main task is the selection of a diagnostic tool that allows to evaluate the pedagogical efficiency of this control. We suggest that educational design should be based on reasonable technological solutions (i. e. on formalized, reproducible methods of activity), as well as allow the management of non-pedagogical (or partially pedagogical) objects and phenomena. One of these phenomena is the concept of communication. We present the substantiation of the criteria of the nature of teaching and the role of younger students in communication relations, which correspond to the peculiarities of educational design – first of all, adaptability and complexity. We describe the diagnostics of younger students’ communication complex and give information about its approbation. We present the analysis of the experimental data, including the analysis of the relationship of communicative skills components of younger students, which are specific for educational design.
Supervisi Klinis Model Proctor dalam Peningkatan Kualitas Perawatan Selama Prosedur Intravena
Authors: Setiawan Herry , Hartiti Tri , Rofi’i Muhamad
Published: October 2019

ABSTRAKKejadian flebitis yang tinggi mencerminkan rendahnya mutu pelayanan keperawatan dalam hal pencegahan dan pengendalian infeksi. Flebitis tinggi disebabkan oleh faktor biologis yaitu perawatan selama prosedur intravena. Kualitas perawatan selama prosedur intravena dipengaruhi oleh kemampuan supervisor ruangan dalam melaksanakan supervisi klinis. Tujuan dari penelitian untuk mengetahui pengaruh supervisi klinis Model Proctor terhadap kualitas perawatan selama prosedur intravena di RSUD Ulin Banjarmasin. Metode penelitian yang digunakan quasy experimental dengan desain penelitian pre-post test with control group dengan jumlah sampel 68 responden diambil dengan teknik sampel non probability sampling terbagi dalam kelompok intervensi dan kontrol. Hasil yang didapatkan pada penelitian ini adalah terdapat pengaruh supervisi klinis Model Proctor terhadap kualitas perawatan selama prosedur intravena dengan nilai p=< 0,000. Terdapat pengaruh supervisi klinis Model Proctor terhadap kualitas perawatan selama prosedur intravena di RSUD Ulin Banjarmasin. ABSTRACTHigh phlebitis events reflected low quality of nursing care in terms of infection prevention and control. High phlebitis caused by a biological factor of treatment during an intravenous procedure. The quality of care during intravenous procedures has influenced by the ability of the supervisor to perform clinical supervision. The purpose of this research is to know the influence of clinical supervision Proctor model on the quality of treatment during intravenous procedure at Ulin General Hospital Banjarmasin. The research method used quasy experimental with pre-post research design with control group with total sample 68 responden taken with sample technique non probability sampling divided into group of intervention and control. The results obtained in this study were the influence of clinical supervision of Proctor Model on the quality of care during intravenous procedure with p = <0.000. There is an influence of the Proctor Model's clinical supervision on the quality of care during the intravenous procedure at Ulin General Hospital Banjarmasin.
Agroecosystem Management on Green Mustard Plants in Wetlands during Dry Season
Authors: Ilhamiyah Ilhamiyah , Salamiah Salamiah , Samharinto Samharinto , Halim Hakimah
Published: October 2019

This research aimed to find a pattern of agroecosystem management that can increase arthropod diversity, production, and Return Cost Ratio (RCR) values in organic wetlands planted during the dry season.  This research was set in Randomized Block Design (RAK) with seven treatments and five repetitions, namely:  1) Intercropping  between green mustard  and basil, with chicken manure and without Bacillus thuringiensis;  2) Intercropping between green mustard and basil with water hyacinth compost, and without B. thuringiensis;  3)  intercropping between green mustard and leek, given water hyacinth compost, and without application B. thuringiensis;  4)Intercropping between green mustard  and leek, given chicken manure, and without application B. thuringiensis;  5) Intercropping between green mustard and leek, given chicken manure, and given B. thuringensis application, doubled of recommended dosage; 6) Intercropping between green mustard and leek with chicken manure, and B. thuringensis application according to recommended dosage; 7) Monoculture of green mustard without organic fertilizer and without the application B. thuringiensis.  From this research, it was concluded that the pattern of agroecosystem management of green mustard that can increase arthropod diversity in organic wetlands planted during dry season was the intercropping treatment between green mustard with basil, together with chicken manure and without B. thuringiensis. Meanwhile, the pattern of agroecosystem management of green mustard that can increase the production of green mustard and RCR value on the organic wetlands planted in the dry season was the intercropping treatment between green mustard with leek, together with chicken manure, and without B. thuringiensis.
A Study on Vertical Upward Welding of Dissimilar Material and Thickness of Thin Plates Using Novel TIG Welding Process
Authors: Huu Manh Ngo , Van Anh Nguyen , Akihisa Murata , Terasaki Hideno
Published: October 2019

A study about influence of heat input on welding defects in vertical upward welding position for dissimilar material and thickness using a new variation of TIG welding torch is done with support of advanced inspection methods SEM and EBSD. With vertical upward welding position, control heat input plays an important role to keep the weld stabilization without defects. On the other hand, TIG welding process using a conventional TIG torch (conventional TIG welding process) has low efficiency and it is difficult to control heat input with high accuracy. So, it is considered that using conventional TIG torch is still a challenge for welding thin plates. In this case, a new variation of TIG torch has been developed. This torch used a constricted nozzle to improve plasma arc characteristics. As a result, it can control efficiently the heat input to prevent the excessive or insufficiency for joining thin sheets. For evaluation of welding quality, advanced examination methods SEM and EBSD were applied to directly observe the welding defects. From the results, the formation mechanism of blowhole inside weld zone in case of welding dissimilar material and thickness was discussed. It is pointed out that when sufficient welding current, the change from weld zone to base metal is uniform, no welding defects such as blowhole was seen. However, in case of low welding current, the thinner base metal is insufficient fusion and the change between weld zone and base metal is not uniform. The blowhole was observed at SS400 material side.
Improved Understanding of Acid Wormholing in Carbonate Reservoirs through Laboratory Experiments and Field Measurements
Authors: Burton Robert C. , Nozaki Manabu , Zwarich Nola R. , Furui Kenji
Published: October 2019

A comprehensive study on wormholing has been conducted to improve the understanding of matrix acidizing in carbonate reservoirs. This work is a continuation of the previous work by Furui et al. (2012a, 2012b). An analysis of additional experimental results, as well as field measurements, is provided to reinforce and extend the wormhole-penetration model and productivity benefits provided by Furui et al. (2012b).

A series of small-block tests and one large-block test under geomechanical stresses have been conducted to characterize wormholing in outcrop-chalk samples. In addition, field data including acid-pumping data and post-stimulation pressure-falloff data have been collected and analyzed to evaluate stimulation effectiveness. Pressure-buildup data from stimulated wells have also been analyzed to evaluate the sustainability of the acid-induced skin benefits. Production-logging data have been used to investigate whether created wormhole networks have remained stable or have collapsed under production stresses. To statistically analyze the data more comprehensively, the new data were also compared to field data available in the literature.

The following conclusions are drawn from an analysis of the laboratory data and field data: (1) A skin value of −4 is achievable in carbonate reservoirs by matrix acidizing; (2) the negative acid skin is relatively stable under production stresses; (3) the wormhole-penetration model is proved to successfully simulate matrix-acidizing processes in both laboratory-scale and field-scale work; (4) the small- and large-block laboratory tests reconfirmed wormholing efficiency, which was discussed as a scale effect in the previous studies; and (5) an understanding of the possible range of wormhole penetration has allowed us to improve field acid treatments and reduce the risk of connecting to water.

This comprehensive study includes acid-linear-coreflooding tests, small-block tests, large-block tests, and field measurements to thoroughly analyze acid wormholing in carbonate rock. The database can be very useful information for understanding, benchmarking, and optimizing future completion/stimulation design.
Psychosocial Syndemic of Suicidal Ideation Among Sexually Transmitted infection Patients in Shanghai, China
Authors: Wang Suping , Ni Yang , Gong Ruijie , Shi Yuan , Cai Yong , Ma Jin
Published: October 2019

Background We sought to verify whether psychosocial health problems among patients with sexually transmitted infections (STIs) were associated with these patients’ suicidal ideation, and to examine the magnifying effect of a syndemic of multiple psychosocial conditions on suicidal ideation. Methods This was a cross-sectional study of 519 STI patients at the Shanghai Skin Disease Hospital. Sociodemographic, psychosocial, and suicidal ideation information on the participants was collected. Logistic regressions were performed to detect the association between sociodemographic variables and suicidal ideation, as well as each individual psychosocial variable and suicidal ideation, and to verify the syndemic effect of psychosocial factors. Results Of the participants, 25.0% reported having suicidal thoughts. In univariate analysis, low self-esteem, loneliness, depression, entrapment, defeat, and unsatisfied interpersonal needs were associated with suicidal ideation. Multivariable analysis found depression (risk ratio [RR] 2.614; 95% confidence interval [CI]: 1.603–4.262) and entrapment (RR: 4.457; 95%CI: 2.649–7.496) remained significant. STI patients who experienced two or more psychosocial health problems had approximately five times the odds of suicide ideation (adjusted risk ratio [ARR]: 4.643; 95%CI: 2.882–7.481) compared with those in the non-syndemic group, especially in the high-level (five or more psychosocial problems) group (ARR: 6.072; 95%CI: 3.307–11.152). Conclusions The study confirmed that STI patients have a high rate of suicidal ideation and suffer from severe psychosocial problems. The results confirm a syndemic effect of psychosocial problems on increasing the odds of suicidal ideation. This suggests greater attention should be paid to STI patients’ psychosocial wellbeing in both nursing and interventions. Efforts to prevent suicidal ideation among STI patients are therefore urgently needed to ameliorate the social and health conditions of this population.
Geographical distribution of family physicians in Japan: A nationwide cross-sectional study
Authors: Yoshida Shuhei , Matsumoto Masatoshi , Kashima Saori , Koike Soichi , Tazuma Susumu , Maeda Takahiro
Published: October 2019

Background: Geographical maldistribution of physicians, and their subsequent shortage in rural areas, has been a serious problem in Japan and in other countries. Family Medicine, a new board-certified specialty started 10 years ago in Japan by Japan Primary Care Association (JPCA), may be a solution to this problem.
Methods: We obtained the workplace information of 527 (78.4%) of the 672 JPCA-certified family physicians from an online database. From the national census data, we also obtained the workplace information of board-certified general internists, surgeons, obstetricians/gynaecologists and paediatricians and of all physicians as the same-generation comparison group (ages 30 to 49). Chi-squared test and residual analysis were conducted to compare the distribution between family physicians and other specialists.
Results: 519 JPCA-certified family physicians and 137,587 same-generation physicians were analysed. The distribution of family physicians was skewed to municipalities with a lower population density, which shows a sharp contrast to the urban-biased distribution of other specialists. The proportion of family physicians in non-metropolitan municipalities was significantly higher than that expected based on the distribution of all same-generation physicians (p<0.001).
Conclusions: Family physicians distributed in favour of rural areas much more than any other specialists in Japan. The better balance of family physician distribution reported from countries with a strong primary care orientation seems to hold even in a country where primary care orientation is weak, physician distribution is not regulated, and patients have free access to healthcare. Family physicians comprise only 0.2% of all Japanese physicians. However, if their population grows, they can potentially rectify the imbalance of physician distribution. Government support is mandatory to promote family medicine in Japan.
Heart Failure Management Insights from Primary Care Physicians and Allied Health Care Providers in Southwestern Ontario
Authors: Silva Narlon C Boa Sorte , Pulford Roseanne W , Lee Douglas S. , Petrella Robert J
Published: October 2019

Background It remains to be determined whether collaborative strategies to improve and sustain overall health in patients with heart failure (HF) are currently being adopted by health care professionals. We surveyed primary care physicians, nurses and allied health care professionals in Southwestern Ontario regarding how they currently manage HF patients and how they perceive limitations, barriers and challenges in achieving optimal management in these patients. Methods We developed an online survey based on field expertise and a review of pertinent literature in HF management. We analyzed quantitative data collected via an online questionnaire powered by Qualtrics®. The survey included 87 items, including multiple choice and free text questions. We collected participant demographic and educational background, and information relating to general clinical practice and specific to HF management. The survey was 25 minutes long and was administered in October and November of 2018 Results We included 118 health care professionals from network lists of affiliated physicians and clinics of the department of Family Medicine at Western University; 88.1% (n=104) were physicians while 11.9% (n=14) were identified as other health care professionals. Two-thirds of our respondents were females (n=72) and nearly one-third were males (n=38). The survey included mostly family physicians (n=74) and family medicine residents (n=25). Most respondents indicated co-managing their HF patients with other health care professionals, including cardiologists and internists. The vast majority of respondents reported preferring to manage their HF patients as part of a team rather than alone. As well, the majority respondents (n=47) indicated being satisfied with the way they currently manage their HF patients; however, some indicated that practice set up and communication resources, followed by experience and education relating to HF guidelines, current drug therapy and medical management were important barriers to optimal management of HF patients. Consultations Most respondents indicated HF management was satisfactory, however, a minority did identify some areas for improvement (communication systems, work more collaborative as a team, education resources and access to specialists). Future research should consider these factors in developing strategies to enhance primary care involvement in co-management of HF patients, within collaborative and multidisciplinary systems of care.
Indications for adjuvant chemotherapy in patients with AJCC stage IIa T3N0M0 and T1N2M0 gastric cancer—an east and west multicenter study
Authors: Huang Ze-Ning , Desiderio Jacopo , Chen Qi-Yue , Zheng Chao-Hui , Li Ping , Xie Jian-Wei , Wang Jia-Bin , Lin Jian-Xian , Lu Jun , Cao Long-Long , Lin Mi , Tu Ru-Hong , Lin Ju-Li , Zheng Hua-Long , Huang Chang-Ming
Published: October 2019

Abstract
Purpose To determine the indications for adjuvant chemotherapy (AC) in patients with stage IIa gastric cancer (T3N0M0 and T1N2M0) according to the 7 th American Joint Committee on Cancer (AJCC)
Methods A total of 1593 patients with T3N0M0 or T1N2M0 stage gastric cancer were identified from the Surveillance, Epidemiology, and End Results (SEER) database for the period 1988.1-2012.12. Cox multiple regression, nomogram and decision curve analyses were performed. External validation was performed using databases of the Fujian Medical University Union Hospital (FJUUH) (n = 241) and Italy IMIGASTRIC center (n = 45).
Results Cox multiple regression analysis showed that the risk factors that affected OS in patients receiving AC were age > 65 years old, T1N2M0, LN dissection number ≤ 15, tumor size > 20 mm, and nonadenocarcinoma. A nomogram was constructed to predict 5-year OS, and the patients were divided into those predicted to receive a high benefit (points ≤ 188) or a low benefit from AC (points > 188) according to a recursive partitioning analysis. OS was significantly higher for the high-benefit patients in the SEER database and the FJUUH dataset than in the non-AC patients (Log-rank < 0.05), and there was no significant difference in OS between the low-benefit patients and non-AC patients in any of the three centers (Log-rank = 0.154, 0.470, and 0.434, respectively). The decision curve indicated that the best clinical effect can be obtained when the threshold probability is 0-92%.
Conclusion Regarding the controversy over whether T3N0M0 and T1N2M0 gastric cancer patients should be treated with AC, this study presents a predictive model that provides concise and accurate indications. These data show that high-benefit patients should receive AC.
Transcriptome Analysis Reveals Mechanism Underlying the Differential Intestinal Functionality of Laying Hens in the Late Phase and Peak Phase of Production
Authors: Wang Weiwei , Wang Jing , Zhang Haijun , Wu Shugeng , Qi Guanghai
Published: October 2019

Background: The compromised performance of laying hens in the late phase of production relative to the peak production was thought to be associated with the impairment of intestinal functionality, which plays essential roles in contributing to their overall health and production performance. In the present study, RNA sequencing was used to investigate differences in the expression profile of intestinal functionality-related genes and associated pathways between laying hens in the late phase and peak phase of production.
Results : A total of 104 upregulated genes with 190 downregulated genes were identified in the ileum (the distal small intestine) of laying hens in the late phase of production compared to those at peak production. These upregulated genes were found to be enriched in little KEGG pathway, however, the downregulated genes were enriched in the pathways of PPAR signaling pathway, oxidative phosphorylation and glutathione metabolism. Besides, these downregulated genes were mapped to several GO clusters in relation to lipid metabolism, electron transport of respiratory chain, and oxidation resistance. Similarly, there were lower activities of total superoxide dismutase, glutathione S-transferase and Na + /K + -ATPase, and reductions of total antioxidant capacity and ATP level, along with an elevation in malondialdehyde content in the ileum of laying hens in the late phase of production as compared with those at peak production.
C onclusion s: The intestine of laying hens in the late phase of production were predominantly characterized by a disorder of lipid metabolism, concurrent with impairments of energy production and antioxidant property. This study uncovers the mechanism underlying differences between the intestinal functionality of laying hens in the late phase and peak phase of production, thereby providing potential targets for the genetic control or dietary modulation of intestinal hypofunction of laying hens in the late phase of production.
Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study
Authors: Pishgahi Alireza , Dolatkhah Neda , Shakouri Seyed Kazem , Hashemian Maryam , Amiri Atefeh , Reihany Morteza Delkhosh , Jahanjou Fatemeh
Published: October 2019

Objectives: Low back pain (LBP) is a common medical problem worldwide. The aim of this study is to evaluate the association between serum concentration of 25-hydroxivitamin D3 and functional disability in patients suffering from LBP in a sample of Azeri middle-aged subjects, North West of Iran.
Results: In this case-control study, 63 eligible patients with LBP and 55 healthy subjects enrolled in the study. Peripheral venous blood was taken for evaluating the serum concentration of 25-hydroxivitamin D3. We recognized factors related with LBP by multiple regression analyses. The average serum 25-hydroxivitamin D3 concentration in case group was significantly lower than that of the matched controlled group (26.25±15.95 vs. 34.20±14.92, p-value < 0.01 respectively). Subjects with vitamin D deficiency or insufficiency were more likely to exhibit LBP than subjects with normal serum 25-hydroxivitamin D3 concentration [(OR= 2.388, 95% CI (1.114 to 5.119)]. According to the partial correlation analysis, there was a reverse correlation between serum 25-hydroxivitamin D3 concentration with functional disability measured by Modified Oswestry Questionnaire (r = -.307, p = .017) and also with pain intensity according to Visual analogue Scale (VAS) score (r = -.268, p = .040) whilst adjusting for age, sex and body mass index (BMI).
Intensive psychotherapy and case management for Karen refugees with Major Depression in primary care: a pragmatic randomized control trial
Authors: Northwood Andrea , Vukovich Maria M , Beckman Alison , Walter Jeffrey P , Josiah Novia , Hudak Leora , Burrows Kathleen O’Donnell , Letts James P , Danner Christine C
Published: October 2019

Background: Despite an unparalleled global refugee crisis, there are almost no studies in primary care addressing real-world conditions and longer courses of treatment that are typical when resettled refugees present to their physician with critical psychosocial needs and complex symptoms. We studied the effects of a year of psychotherapy and case management in a primary care setting on common symptoms and functioning for Karen refugees (a newly arrived population in St Paul, Minnesota) with depression.
Methods: A pragmatic parallel-group randomized control trial was conducted at two primary care clinics with large resettled Karen refugee patient populations, with simple random allocation to one year of either: (1) intensive psychotherapy and case management (IPCM), or (2) care-as-usual (CAU). Eligibility criteria included Major Depression diagnosis determined by structured diagnostic clinical interview, Karen refugee, ages 18-65. IPCM (n=112) received a year of psychotherapy and case management coordinated onsite between the case manager, psychotherapist, and primary care providers; CAU (n=102) received care-as-usual from their primary care clinic, including behavioral health referrals and/or brief onsite interventions. Blinded assessors collected outcomes of mean changes in depression and anxiety symptoms (measured by Hopkins Symptom Checklist-25), PTSD symptoms (Posttraumatic Diagnostic Scale), pain (internally developed 5-item Pain Scale), and social functioning (internally developed 37-item instrument standardized on refugees) at baseline, 3, 6 and 12 months. After propensity score matching, data were analyzed with the intention-to-treat principle using repeated measures ANOVA with partial eta-squared estimates of effect size.
Results: Of 214 participants, 193 completed a baseline and follow up assessment (90.2%). IPCM patients showed significant improvements in depression, PTSD, anxiety, and pain symptoms and in social functioning at all time points, with magnitude of improvement increasing over time. CAU patients did not show significant improvements. The largest mean differences observed between groups were in depression (difference, 5.5, 95% CI, 3.9 to 7.1, P <.001) and basic needs/safety (difference, 5.4, 95% CI, 3.8 to 7.0, P <.001).
Conclusions: Adult Karen refugees with depression benefited from intensive psychotherapy and case management coordinated and delivered under usual conditions in primary care. Intervention effects strengthened at each interval, suggesting robust recovery is possible.
Robotic, laparoscopic or open hemihepatectomy for giant liver hemangiomas of over 10 cm in diameter
Authors: Hu Minggen , Chen Kuang , Zhang Xuan , Li Chenggang , Song Dongda , Liu Rong
Published: October 2019

[EXSCINDED]
Abstract
Abstract
Abstract

Background
To evaluate the clinical efficacy of robotic, laparoscopic, and open hemihepatectomy for giant liver hemangiomas.Methods

From April 2011 to April 2017, consecutive patients who underwent hemihepatectomy for giant liver hemangiomas were included into this study. According to the type of operation, these patients were divided into the robotic hemihepatectomy (RH) group, the laparoscopic hemihepatectomy (LH) group, and the open hemihepatectomy (OH) group. The perioperative and short-term postoperative outcomes were compared among the three groups. The study was reported following the STROCSS criteria.Results

There were no significant differences in age, sex, tumor location, body surface area (BSA), future liver remnant volume (FLR), standard liver volume (SLV), liver hemangioma volume, FLR/SLV, resected normal liver volume / resected volume, hepatic disease, rates of blood transfusion, liver function after 24 hours of surgery, operative morbidity and mortality among the three groups. Compared with patients in the RH group (n=19), and the LH group (n=13), patients in the OH group (n=25) had significantly longer postoperative hospital stay (P< 0.05), time to oral intake (P < 0.05), time to get-out-of-bed (P < 0.05), a higher VAS score after 24 hours of surgery (P < 0.05) and a shorter operative time (P < 0.05). There were no significant differences in these postoperative outcomes (P>0.05) between the RH group and the LH group. When the setup time in the RH group was excluded, the operative time of the RH group was significantly shorter than the LH group (P<0.05). There was no significant difference in the operative time between the RH group and the OH group (P>0.05). The intraoperative blood loss of the RH group was the least among the three groups (P<0.05) and the intraoperative blood loss of the LH group was less than the OH group (P<0.05).Discussion

Robotic, laparoscopic, and open hemihepatectomy were safe and efficacious treatments for giant liver hemangiomas. Robotic and laparoscopic hemihepatectomy were significantly better than open hemihepatectomy in intraoperative blood loss, postoperative recovery and pain score. Compared with laparoscopic hemihepatectomy, robotic hemihepatectomy resulted in significantly less intraoperative blood loss and shorter operative time.
Assessment of Drug-Related Problems among Type 2 Diabetic Patients on Follow up at Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia
Authors: Abdulmalik Haymen , Tadiwos Yohannes , Legesse Nanati
Published: October 2019

Objectives: To assess the drug-related problem among patients with type 2 diabetes at Hiwot Fana Specialized University Hospital
Results: In this study, a total of 148 patient medication records were included. More than half, 83(57.4%) were men and the rest 65(42.6%) were women. The mean age of the study participants was 51.26 ± 7.08. Around one third (74.3%) of the participants had urban residency. A total of 127 drug-related problems were identified, of which dosage too low was the most common type of DRP encountered, 46(36.2%), followed by unnecessary drug therapy, 25(19.7%) and ineffective drug therapy, 25(19.7%). 95(64.2%) of the patients had at least one drug-related problem. Among patients with DRP, more than half of them, 59 (62.1%) had a single DRP. Out of the total participants, 85(57.4%) of them were taking one anti-diabetic medication and 63(42.6%) of them dual anti-diabetic medications. Only half of the patients have attained the desired FBG level. There was no patient who had experienced more than two types of drug-related problems at a time. Less than 10% of patients were taking five or more drugs at a time.

Key Words: Diabetes mellitus, Drug therapy problem, Hiwot Fana specialized university hospital.
Effects of parental genetic divergence on gene expression patterns in interspecific hybrids of Camellia
Authors: Zhang Min , Tang Yi-Wei , Qi Ji , Liu Xin-Kai , Yan Dan-Feng , Zhong Nai-Sheng , Tao NAi-Qi , Gao Ji-Yin , Wang Yu-Guo , Song Zhi-Ping , Yang Ji , Zhang Wen-Ju
Published: October 2019

Background: The merging of two divergent genomes during hybridization can result in the remodeling of parental gene expression in hybrids. A molecular basis underling expression change in hybrid is regulatory divergence, which may change with the parental genetic divergence. However, there still no unanimous conclusion for this hypothesis.
Results : Three species of Camellia with a range of genetic divergence and their F 1 hybrids were used to study the effect of parental genetic divergence on gene expression and regulatory patterns in hybrids by RNA-sequencing and allelic expression analysis. We found that though the proportion of differentially expressed genes (DEGs) between the hybrids and their parents did not increase, a greater proportion of DEGs would be non-additively (especially transgressively) expressed in the hybrids as genomes between the parents become more divergent . In addition, the proportion of genes with significant evidence of cis -regulatory divergence increased , whereas with trans -regulatory divergence decreased with parental genetic divergence.
Conclusions : The discordance within hybrid would intensify as the parents become more divergent, manifesting as more DEGs would be non-additively expressed. Trans -regulatory divergence contributed more to the additively inherited genes than cis , however, its contribution to expression difference would be weakened as cis mutations accumulated over time; and this might be an important reason for that the more divergent the parents are, the greater proportion of DEGs would be non-additively expressed in hybrid.
C3a receptor activation promotes uric acid or LPS-induced CCL2 production in proximal tubular epithelial cells
Authors: You Danyu , Luo Congwei , Yang Liyan , Cui Jiong , Chen Yi , Wan Jianxin
Published: October 2019

Background To identify the role of the interaction of complement fragment 3a (C3a) and its receptor C3aR in uric acid (UA) or lipopolysaccharide (LPS)-induced CCL2 expression in human renal proximal tubular epithelial cell line HK-2.Methods HK-2 cells were cultured in vitro and treated with UA or LPS to induce the production of CCL2. To determine the role of C3a-C3aR interaction in CCL2 production, HK-2 cells exposed to UA or LPS were pretreated with the small molecule sb290157 (1μmol/l) or recombinant C3a protein (100nmol/l) to block or amplify C3a-C3aR interaction. The expression of CCL2, C3 and C3aR were detected by real-time quantitative PCR (Q-PCR), enzyme-linked immunosorbent assay (ELISA) and Western Blotting.Results 12 hours of UA (150μmol/L) stimulation or 8 hours of LPS (5μg/ml) treatment significantly induced CCL2 and C3 mRNA transcription in HK-2 cells. The expression of CCL2 induced by UA or LPS could be abrogated by C3aR blockade. C3a stimulation alone has little effect on inducing CCL2 expression in HK-2 cells. However, when it stimulated the HK-2 cells together with UA or LPS, it could remarkably potentiate UA or LPS-induced CCL2 expression.Conclusion The activation of C3aR provides an important co-stimulating signal for CCL2 production in HK-2 cells and blocking the interaction of C3a-C3aR will significantly inhibit UA or LPS induced CCL2 production.
The management of platelet-rich plasma in ONFH treatment: A systematic review
Authors: Han Jun , Gao Fuqiang , Sun Wei , Shi Lijun , Wu Xinjie , Li Tengqi
Published: October 2019

Background: Osteonecrosis of femoral head (ONFH) is a pathologic process characterized by the lacking vessel blood of femoral head leading to cellular death, fracture, and collapse of the articular surface. Currently, critical treatment for early stage ONFH is limited to core decompression. However, the efficacy of core decompression remains controversial. With the purpose to improve the core decompression efficacy, regenerative techniques like platelet-rich plasma (PRP) have been proposed to address early stage ONFH. PRP is defined as a sample of autologous blood with concentrations of platelets above baseline values, which have an important role in tissue repair, regeneration, and differentiation of mesenchymal stem cells (MSCs). Within this review, we will present a comprehensive overview of operation modes, mechanism and efficacy of PRP for early stage ONFH treatment. Methods: We searched Pubmed, Embase, Web of Science databases for relevant studies. Any observational or experimental studies that evaluated PRP, MSC, core decompression and ONFH were our goal of searching the electric database. Results: 17 studies that researched PRP and ONFH were identiﬁed in this review. We reviewed 10 studies related to the possible mechanism of PRP for treating ONFH. On the other hand, 7 studies were about to the operation modes of PRP in treating ONFH so far. We reviewed the efficacy of PRP in treating ONFH systematically, with an attempt to make a comparison of PRP operation modes of 7 studies and other operation modes of past studies in early stage ONFH treatment. Conclusion: PRP works to treat ONFH mainly through three mechanisms: induce angiogenesis and osteogenesis to accelerating bone healing; inhibit inflammatory reaction in necrosis lesion; prevents apoptosis induced by glucocorticoid. In addition, PRP are recommended as an adjunctive therapy for core decompression to improve the treatment of early stage ONFH patients, especially combined with stem cells and bone graft to induce an osteogenic activity and stimulate differentiation of stem cell in necrosis lesion.
Percutaneous repair versus open repair for acute Achilles tendon rupture
Authors: wang xiaomeng , Liu Huixin , li dengke , luo zixuan , Li Yansen , Zhang Fengqi
Published: October 2019

Backgroup: To compare the operative outcome between modified Kessler suture method and Bundle-Bundle suture for the treatment of acute rupture of Achilles tendon. Methods: A consecutive series of 72 patients who underwent operation of Achilles tendon rupture were evaluated. Thirty patients were treated by the bundle-bundle suture method (group A) and 31 patients by modified Kessler suture (group B). Functional examination included measurement of calf muscle circumference, and a single-leg heel-rise test. The diameter of the Achilles tendon of the trouble side was recorded compared with the contralateral limb through the MRI (magnetic resonance imaging). The number of single-leg heel-rise was recorded within 15s (height>5cm) compared with the uninjured side. The ankle joint range of motion is recorded. The evaluation form ATRS(Achilles Tendon Total Rupture Score), AOFAS(American Orthopedic Foot And ankle Society) Ankle-Hindfoot scale scores and VAS( visual analogue scale) pain score were used to evaluate the clinical outcome after a minimum follow-up period of 12 months postoperatively. Results: 61 patients at 1 year following surgery. There was no difference in mean follow-up time between the two groups (group A: 23.73±2.81 months; group B: 22.61±3.96 months). There were significant differences between the groups in heel-rise test 1.74±0.96 in group A, 2.37±1.42 in group B. Compared with the group B, the calf circumference of the injured side was bigger in group A (p=0.043). The cross-sectional diameters of the Achilles tendon after open repair was significantly different from that after percutaneus repair. There were no significant differences in ATRS, AOFAS and VAS at the final follow-up between the two groups. One patients of group A experienced delayed wound healing, which resolved in about 40 days. Conclusions : Two suture methods can provide good clinical results. Bundle-Bundle suture is more effective in solving the shortcomings of traditional methods. It is a safe and effective method, and is worthy of promotion.