bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Advances in Bedside Device-Based Early Detection of Sepsis
Authors: D. Somogyi Rita , C. Sheridan David
Published: December 2021

Early detection of sepsis is challenging to achieve with current diagnostic methods, leading to expenditures of $27 billion annually in the United States with significant associated mortality. Various scoring systems have been proposed such as the sequential organ failure assessment (SOFA) and systemic inflammatory response syndrome (SIRS) criteria for identification of sepsis, but their sensitivities range from 60% to 70% when used in the emergency department triage. Other methods for the recognition of sepsis may rely on laboratory work, in addition to vitals monitoring, and are often outpaced by the development of sepsis. Automated alerts have not shown any reduction in mortality thus far. New technology may fill a critical gap in the early detection of sepsis. The ideal bedside screening device for would demonstrate rapid time to result, high portability, and high sensitivity to not miss cases, but also reasonable specificity to prevent provider fatigue from excessive false alerts. Non-invasive end-organ perfusion devices analyzing lactate and capillary refill time (CRT) tend to perform well in speed and portability, but may be less sensitive. Biomarker devices demonstrate a wider array of performance metrics. Those analyzing a single biomarker tend to be more sensitive but are less specific to the diagnosis of sepsis than technologies that assess multiple biomarkers, which in turn have lower sensitivity. Additionally, biomarker devices are generally invasive requiring blood samples, which may or may not be feasible in all patients especially when serial draws are needed. Sepsis is a complex disease process and most likely will require a combination of improved technology in addition to vital signs and high-risk patient history for better recognition. This review examines recent advances in the device-based early detection of sepsis between 2017 and 2020 with emphasis on bedside diagnostics, divided into markers of perfusion and biomarkers commonly implicated in sepsis.
Impact of injectable chitosan cryogel microspherescaffolds on differentiation and proliferation of adiposederived mesenchymal stem cells into fat cells
Authors: Çekiç Duran , Yılmaz Şakir Necat , Bölgen Nimet , Ünal Selma , Duce Meltem Nass , Bayrak Gülsen , Demir Didem , Türkegün Merve , Sarı Alper , Demir Yavuz , Ünal Şakir
Published: December 2021

Difficulty in the clinical practice of stem cell therapy is often experienced in achieving desired target tissue cell differentiation and migration of stem cells to other tissue compartments where they are destroyed or die. This study was performed to evaluate if mesenchymal stem cells (MSCs) may differentiate into desired cell types when injected after combined with an injectable cryogel scaffold and to investigate if this scaffold may help in preventing cells from passing into different tissue compartments. MSCs were obtained from fat tissue of the rabbits as autografts and nuclei and cytoplasms of these cells were labeled with BrdU and PKH26. In Group 1, only-scaffold; in Group 2, only-MSCs; and in Group 3, combined stem cell/scaffold were injected to the right malar area of the rabbits. At postoperative 3 weeks, volumes of the injected areas were calculated by computer-tomography scans and histopathological evaluation was performed. The increase in the volume of the right malar areas was more in Group 3. In histopathological evaluation, chitosan cryogel microspheres were observed microscopically within the tissue and the scaffold was only partially degraded. Normal tissue form was seen in Group 2. Cells differentiated morphologically into fat cells were detected in Groups 2 and 3. Injectable chitosan cryogel microspheres were used in vivo for the first time in this study. As it was demonstrated to be useful in carrying MSCs to the reconstructed area, help cell differentiation to desired cells and prevent migration to other tissue compartments, it may be used for reconstructive purposes in the future.
The improvement of biocompatibility by incorporating porphyrins into carbon dots with photodynamic effects and pH sensitivities
Authors: Sajjad Faiza , Han Yiping , Bao Leilei , Yan Yijia , O shea Donal , Wang Laixing , Chen Zhilong
Published: December 2021

Photodynamic therapy (PDT) is a promising new treatment for cancer; however, the hydrophobic interactions and poor solubility in water of photosensitizers limit the use in clinic. Nanoparticles especially carbon dots have attracted the attention of the world’s scientists because of their unique properties such as good solubility and biocompatibility. In this paper, we integrated carbon dots with different porphyrins to improve the properties of porphyrins and evaluated their efficacy as PDT drugs. The spectroscopic characteristics of porphyrins nano-conjugates were studied. Singlet oxygen generation rate and the light- and dark-induced toxicity of the conjugates were studied. Our results showed that the covalent interaction between CDs and porphyrins has improved the biocompatibility. The synthesized conjugates also inherit the pH sensitivity of the carbon dots, while the conjugation also decreases the hemolysis ratio making them a promising candidate for PDT. The incorporation of carbon dots into porphyrins improved their biocompatibility by reducing toxicity.
Can Emerging Adults’ Dating Psychological Aggression be Explained by Family-of-Origin Psychological Aggression, Emotion Dysregulation, and Drinking?
Authors: Dhruve Deepali M. , Oliveros Arazais D.
Published: December 2021

Intimate partner violence (IPV) impacts the lives of millions of individuals; nearly 1 in 4 women and 1 in 7 men report experiencing IPV during their lifetime. Previous studies frequently cite family-of-origin aggression as a risk factor for later experiences with IPV. Research with adults who engage in IPV finds an association with childhood exposure to family violence, but the strength of that association may vary. Psychological aggression often pre-dates more severe IPV and college students are a particular risk group for IPV. Additionally, previous literature has revealed gender differences in response to childhood experiences of family violence. As such, the current study sought to identify factors that explain and moderate risk for dating psychological aggression (DPA) in college adults, and sex differences in those associations. Participants (464 women, 142 men), who were in a current romantic relationship lasting at least 3 months, completed measures of past psychological aggression in the family-of-origin (PAF), current emotion dysregulation, risky drinking, and DPA perpetrated in current dating relationships. Emotion dysregulation mediated the relationship between PAF and current DPA; however, differences among specific types of PAF and sex were noted. Results support an intergenerational transmission of PAF and suggest that parent–child sex dyads influence this process. The findings also provide evidence that higher levels of drinking are associated with increased emotion dysregulation. These results contrast with the alcohol expectancy for stress relief and support public messaging that alcohol use does not relieve stress. Clinical and research implications for prevention of the intergenerational transmission of aggression are discussed.
Toward a New Rural Typology: Mapping Resources, Opportunities, and Challenges
Authors: Khalaf Christelle , Michaud Gilbert , Jolley G. Jason
Published: December 2021

While the concept of rurality has been debated in academic and professional literature for decades, less research has been done on a practical typology that can guide localized economic development strategies. This paper adds to the growing body of literature in search of a more nuanced definition of rural by applying unsupervised machine learning (ML) to the abundance of existing county-level data in the United States. The authors illustrate how this method can lead to a new county typology, named after economic development strategies, that accounts for idiosyncrasies in resources, opportunities, and challenges. This research serves as a practical step toward tractable, heterogeneous classifications that can inform the work of federal, state, and local policy makers, economic development practitioners, and many others.
Conducting Research in Difficult, Dangerous, and/or Vulnerable Contexts: Messy Narratives From the Field
Authors: Peterson Brittany L. , Albu Oana B. , Foot Kirsten , Hutchins Darvelle , Qiu Jack , Scott Craig R. , Stohl Michael , Tracy Sarah J.
Published: December 2021

Organizational communication scholars have historically conducted research in large for-profit businesses, governmental agencies, and a few high-profile nonprofits/NGOs—all of which are relatively easy to access and presumably “safe” to study. It is largely unsurprising, then, that limited scholarship addresses the challenges associated with conducting research in less standard contexts that are often perceived to be difficult, dangerous, and/or vulnerable (DDV). In this forum, we offer lived stories—unfiltered messy narratives—to demystify three core ethical challenges inherent in conducting research of this nature and share how we (imperfectly) navigated them. In addition, we offer practical strategies for conducting research in DDV contexts. Taken together, our overall collective aim is to successfully prepare future scholars to conduct research projects in DDV contexts.
The Social and Political Significance of Technology-Driven Organisational Change: Discursive Battles to Frame, Define and Decide in ‘a Space of Points of View’
Authors: Ernst Jette
Published: December 2021

Struggles over new organisational technology are, almost without exception, studied inside organisations. This paper aims to advance our understanding of how technology is embedded in social forces and relations of power that reach beyond individual organisations. It examines the ongoing discursive struggles in public media outlets between consultant doctors and regional actors concerning a controversial electronic health record (EHR) system, called the Health Platform, which was implemented in 20 Danish hospitals. A theoretical framework inspired by Bourdieu’s understanding of discursive activity in a field subsumed in a multi-level and cultural understanding of framing is used to examine the interests connected to platform design and its organisational future states. It is demonstrated that winning the support of the public is pivotal in the construction of frames by both groups of actors in their efforts to define problems and solutions and, ultimately, influence a political decision concerning the platform’s future.
Refugees’ Meaning of Work: A Qualitative Investigation of Work Purposes and Expectations
Authors: Fedrigo Laurence , Cerantola Marine , Frésard Caroline E. , Masdonati Jonas
Published: December 2021

This study explores the meaning of work for 22 young refugees aged from 18 to 35 from Afghanistan, Eritrea, Iran, Somalia, Syria, Turkey, Ukraine, and Yemen through semistructured interviews. Using consensual qualitative research, we sought to understand the purposes work fulfills, their work expectations, and how purposes and expectations might have changed over time. Results showed that work fulfills many purposes found in the literature, (e.g., development, structure, health, identity, and material benefits) as well as purposes in relation with others and the larger society. Participants expect their work to correspond to their selves (e.g., interests and personality), offer decent working conditions, and allow meaningful relationships and opportunities to help others. Illustrations of two participants’ paths provided insights into a possible change of meaning of work. In addition to implications for practice, the influence of relational and contextual factors is discussed.
Civil Society and Philanthropy in Africa: Parallels, Paradoxes and Promise
Authors: Obadare Ebenezer , Krawczyk Kelly
Published: December 2021

Civil society and philanthropy in Africa are regularly theorized in formal terms and oft perceived as inherently democratizing forces. Yet, existing evidence exposes the limitations of these assumptions. This article provides an introduction to the symposium issue on civil society and philanthropy in Africa. The objective of the introduction, and the articles contained in the symposium, is to examine important questions related to civil society and philanthropy on the continent: What is the complex history and role of civil society and philanthropy in Africa? How have donor dependence and professionalization affected the effectiveness of the third sector? What are the contours of the relationship between the state and civil society? We ask these crucial questions in an attempt to provide a more nuanced and contextualized understanding of civil society and philanthropy on the continent.
On the Front Line of the Circular Economy: The Entrepreneurial, Identity and Institutional Work of a Female Entrepreneur towards the Circular Transition
Authors: Bozkurt Ödül , Xheneti Mirela , Vicky
Published: December 2021

This article traces the experiences of Vicky, a female entrepreneur who runs a circular business that produces swim and activewear from regenerated fishing nets. The idea of a circular economy, which moves away from the linear economic model based on a make-use-dispose logic towards the elimination of waste and a sustainable use of the world’s resources, has rapidly gained popularity. Vicky’s story highlights the often overlooked but critical role of small businesses and their owners in this systemic change. Vicky performs three intertwined but distinct forms of work – entrepreneurial work on the business, identity work on the self and institutional work on the wider world – that all contribute to the circular transition. At the same time, Vicky exemplifies an alternative approach to entrepreneurship through a relational interpretation of circularity. Her case draws attention to how the labour of actors in the grassroots propels large-scale transitions.
Predicting flow stress of Ni steel based on machine learning algorithm
Authors: Cao Guang-Ming , Gao Zhi-Wei , Gao Xin-Yu
Published: December 2021

This article builds a stress–strain prediction model based on production data from the steel industry by using machine learning algorithms. Based on the stress–strain data of 9Ni steel hot deformation behavior, the prediction model of flow stress constitutive equation of 9Ni steel is established. Four models, including Arrhenius-type model considering strain compensation, Arrhenius-type model of Stochastic Configuration Networks (SCNs) neural network, Arrhenius-type model of Multi-objective Particle Swarm Optimization (AMPSO) and Support Vector Machine (SVM) model, are adopted in this research. The results show that the Arrhenius-type model considering strain compensation can predict the stress trend under different deformation conditions, but its prediction accuracy has some deviation. The prediction model based on SVM algorithm has the best prediction accuracy. The square of Correlation Coefficient (R2), the Average Absolute Relative Error (AARE), and Mean Square Error (MSE) are 0.99996, 0.002455, and 0.1998, respectively. Based on the data of 9Ni steel hot deformation behavior, the prediction models of machine learning algorithm have good application prospects in steel industry.
Numerical investigations of heat transfer around a hot block subject to a cross-flow and an extended jet hole using ternary hybrid nanofluids
Authors: Boudraa Bouziane , Bessaïh Rachid
Published: December 2021

In the last few years, modern heat transfer technologies significantly improved to provide more efficient systems in industries. One of those technologies is cooling electronic components in laminar flow using water nanofluids, which is interesting. This research used a ternary hybrid nanofluid with various nanoparticle forms to conduct a numerical investigation of three-dimensional heat transfer and fluid flow over a heated block exposed to a horizontal flow and an impinging jet. The effects of several variables such as the Reynolds number ratio [Formula: see text], volume fraction of nanoparticles [Formula: see text], length of extended jet hole [Formula: see text], and the influence of the inclination angle of the impinging jet inlet [Formula: see text] on the fluid flow and heat transfer were examined. Using the Ansys-Fluent 14.5 program and under laminar flow conditions, the finite-volume method was applied with the help of the SIMPLE algorithm to solve continuity, momentum, and energy equations. Several characteristics are assessed, including velocity streamline, isotherm contours, Nusselt number contours, the average Nusselt number ([Formula: see text]), the friction factor [Formula: see text], and drop pressure [Formula: see text]. The findings of the current analysis revealed that adding an impinging jet can boost the heat transfer rate up to [Formula: see text] better than a non-impingement jet. Also, a significant enhancement in the heat transfer rate was obtained when growing one of these parameters α, [Formula: see text], and E. Moreover, the ternary hybrid nanofluid with different nanoparticle forms significantly boosts the heat transfer rate compared to the traditional nanofluid. The maximum heat transfer is reached as the velocity of the impinging jet rises. Inclining the angle of the impinging jet inlet with [Formula: see text] toward the channel inlet boosted the rate of heat transfer up to [Formula: see text] compared to the perpendicular impinging jet [Formula: see text]. A strong consensus has been reached with the theoretical and experimental findings found in the literature.
Effects of working conditions on the operating characteristics of an injection system applied on CNG fueled vehicles
Authors: Hung Nguyen Ba , Tuan Le Anh , Lim Ocktaeck
Published: December 2021

A model-based study is conducted to examine the operating characteristics of an injection system applied on CNG fueled vehicles. This injection system is a combination of an electric pressure regulator, a rail tube, and a solenoid injector. The electric pressure regulator has a great potential to be widely used in injection systems of natural gas-fueled engines due to its flexible operation, which can help to improve the engine performance and reduce emission. This paper presents a simulation study using mathematical models to describe and analyze the operating characteristics of the gaseous fuel injection system, in which models of electric pressure regulator, solenoid fuel injector, and control model for electric pressure regulator are presented. The simulation results are compared with experimental data to validate the simulation models. Effects of working conditions, including coil resistance of the electric pressure regulator, inlet gas pressure, and set pressure in the rail tube, on the operating characteristics of the gaseous fuel injection system are investigated. Simulation results show that when the coil resistance of the electric pressure regulator is increased from 3.1 Ω to 4.1 Ω, the maximum fluctuation of the controlled gas pressure in the rail tube is reduced from 0.017 to 0.012 MPa, respectively. By decreasing the inlet gas pressure of the electric pressure regulator from 2.5 to 2.3 MPa, the controlled gas pressure in the rail tube is more stable with the maximum fluctuation significantly reduced from 0.012 to 0.002 MPa, respectively, which leads to stability in injection flow rate. The increase of set pressure in the rail tube from 0.5 to 0.7 MPa can help to improve the stability of the controlled gas pressure in the rail tube with the maximum fluctuation respectively reduced from 0.002 to 0.001 MPa.
Numerical investigation on the impact of multiple injection strategies and spray included angles on combustion and emissions in a marine diesel engine
Authors: Kong Shiru , Zhao Changpu , Bian Zhishang , Cai Yujie
Published: December 2021

The computational fluid dynamical software AVL-FIRE code was used for investigating the impact of multiply injection strategies and spray included angles on combustion and emissions in a marine diesel engine. The fuel injection parameters of spray included angle and pilot injection timing with pilot-main injection, as well as post injection ratio and post injection duration angle with pilot-main-post injection, were all investigated and optimized. The results indicate that retarding pilot injection timing with pilot-main injection declines high temperature region, resulting in a notable reduction in NOx emissions. Since fuel evaporation and burn are hampered by long spray penetration due to low temperature and pressure with pilot injection, a suitable spray included angle are used to offer more efficient air-fuel mixing process. A wider spray included angle simultaneously reduces soot emission and indicated specific fuel consumption (ISFC). Post injection fuel exerts impact on combustion process by causing a great disturbance to flow field during post combustion. Increasing post injection ratio from 4% to 10% at a small post injection duration angle great emission performance is achieved by simultaneous reduction in NOx and soot emissions while only using a slight consumption of ISFC. To summarize, the defeat of traditional NOx-soot trade-off occurs as both NOx and soot emissions are decreased with optimized multiple injection strategy and spray included angle. Particularly, there are respectively four cases with pilot-main injection and two cases with pilot-main-post injection, that achieve simultaneous reduction in NOx emissions, soot emission, and ISFC, compared to the prototype.
Late-Holocene relative sea-level changes and palaeoenvironment of the Pre-Viking Age ship burials in Salme, Saaremaa Island, eastern Baltic Sea
Authors: Nirgi Triine , Grudzinska Ieva , Kalińska Edyta , Konsa Marge , Jõeleht Argo , Alexanderson Helena , Hang Tiit , Rosentau Alar
Published: December 2021

Two unique Pre-Viking Age ship burials were found from Salme village, Saaremaa Island, eastern Baltic Sea, containing remains of seven men in the smaller and 34 men in the larger ship. According to the archaeological interpretations, these ships belonged to a viking crew possibly from the Stockholm-Mälaren region, eastern Sweden. Geoarchaeological research was conducted in the area to reconstruct Late-Holocene relative sea-level (RSL) changes and shoreline displacement to provide environmental context to these burials. In this paper we present a Late-Holocene shore displacement curve for the Saaremaa Island and GIS-based palaeogeographic reconstructions for the Salme area. The curve shows an almost linear RSL fall from 5.5 to 0.8 m a.s.l. between 1000 BC and 1300 AD with an average rate of 2 mm/year. A slowdown in regression may be attributed to accelerated sea-level rise after the Little Ice Age and during the industrial period, being consistent with the tide-gauge measurements from the 20th century. Palaeogeographic reconstructions indicate the existence of a strait in the Salme area during the burial of the ships. The eastern part of the strait with water depth up to 2.8 m was about 80–100 m wide. The relatively steep and wind-protected shores in that part of the strait were probably the best places in the area for landing the viking ships. According to sedimentological evidence and diatom data, the narrowing of Salme palaeostrait occurred between 1270 and 1300 AD. Salme I and II ships were buried at 650–770 AD into the sandy-gravelly coastal deposits which had accumulated there in the open coastal zone about 710–450 years earlier. Reconstructions show that the ships were located about 2–2.5 m above coeval sea level and more than 100 m from the coastline. Thus, both ships were probably moved from the shore to the higher ground for burial.
Library services enriching community engagement for dementia care: The Tales & Travels Program at a Canadian Public Library as a case study
Authors: Dai Jiamin , Bartlett Joan C. , Moffatt Karyn
Published: December 2021

Growing dementia-friendly library services are contributing to community-based dementia care. Emerging community programs in libraries and museums provide notable opportunities for promoting engagement and inclusivity, but these programs have yet to receive in-depth assessments and analyses to guide future research and practice. This paper presents a case study examining a social and storytelling program for people with dementia run by a Canadian public library. It investigates two research questions: How can public library programs contribute to community-based dementia care? And what are public libraries’ strengths and challenges in running programs for people with dementia? The study involves participant observations of the program and semi-structured interviews with people with dementia, caregivers, and program facilitators (librarians and Alzheimer Society coordinators). Through thematic analysis of fieldnotes and transcripts, the study reveals how this inclusive platform supports engagement, fosters relationships, helps caregivers, and reaches broader communities. This research further uncovers the librarians’ diversified roles as demonstrated through their collaboration with professionals, preparation and research, and facilitation of the sessions. This paper advances librarianship research on enriching community-based dementia care, including furthering inclusivity and engagement and extending accessible library services. By analyzing library programming for the dementia community and assessing its strengths and challenges, the paper highlights librarians’ awareness of the community’s evolving needs and their collaboration with other professionals. It offers practical insights on useful resources and emerging best practices that will hopefully inspire other initiatives in which information professionals can help improve the well-being of vulnerable populations.
Hydroxychloroquine blood levels predicts flare in childhood-onset lupus nephritis
Authors: Andrade Balbi Verena , Artur Silva Clovis , Nascimento Pedrosa Tatiana , Maria Rodrigues Pereira Rosa , Maria de Arruda Campos Lucia , Pires Leon Elaine , Duarte Nilo , Melechco Carvalho Valdemir , Gofinet Pasoto Sandra , Cordeiro do Rosário Debora , Kolachinski Brandao Leticia , I Brunner Hermine , Bonfá Eloisa , Emi Aikawa Nadia
Published: December 2021

Objective

Low hydroxychloroquine (HCQ) blood levels are predictors of flare in adult lupus. Childhood-onset systemic lupus erythematosus (cSLE) has high morbidity with renal involvement in up to 80% of cases. The aim of this study is to determine the HCQ cut-off levels which predicts flare in childhood-onset lupus nephritis (LN).

Methods

Sixty LN patients on HCQ use for at least 6-months were prospectively evaluated at baseline (BL) and about 6-months later for cSLE flare and HCQ blood levels (ng/mL) measured by liquid chromatography-tandem mass spectrometry.

Results

There were 19 patients (32%) with flare, during the study with median SLEDAI increase of 4 (0–8). Median (IQR) BL HCQ levels of the flare group were lower compared to stable patients [557.5 (68.6–980.3) vs. 1061.9 (534.8–1590.0 ng/mL); p=0.012]. ROC curve analysis demonstrated that HCQ levels≤1075 ng/mL were associated with a 5.08 (95%CI 1.28-20.13; p=0.021) times increased risk of flare. Six-month HCQ levels revealed that most patients 24/54 (44%) had persistently low levels (≤1075) during follow-up. Among those, 11/24 (46%) had flare. Multiple logistic regression analysis including prednisone use, baseline SLEDAI-2K, adherence based on pharmacy refill and BL HCQ blood levels as possible predictors of flare revealed that only HCQ blood level was independently associated with flare (OR 0.999, 95%CI 0.998-1.0, p=0.013).

Conclusions

We demonstrated that HCQ blood cut-off level under 1075 ng/mL predicts flare in childhood-onset LN patients under prescribed HCQ dose of 4.0–5.5 mg/kg/day. We further observed that most of these patients have compliance issues reinforcing the need for a close surveillance particularly in those with levels below the defined cut-off.
From the Semi-Periphery with Love. A Dream of a Democratic Social Science: A Margin Lever
Authors: Chutorański Maksymilian , Szwabowski Oskar
Published: December 2021

The article highlights a set of specific solutions for international journals - “The Margin Lever”. The proposed solutions relate to changes in publishing policies and methods of reviewing texts that may contribute to overcoming the hegemony of scientists coming from the richest, top-rated, perfectly adapted universities. These universities are usually located in the richest and most developed countries - we call them the core, or the center of the scholarly world. The margin lever is designed, not to make competition with them equitable, but rather to contribute to the development of democratic networks, and support global and local efforts within committed social research.
Intercultural Competence Development Through Cocurricular and Extracurricular At-Home Programs in Japan
Authors: Hofmeyr Ana Sofia
Published: December 2021

The rapid development of international education has occurred alongside a growing demand for higher education institutions to educate globally competent graduates. Yet, mobility remains a distant opportunity for most students, and Japanese undergraduate students often cite financial, safety, and job-hunting concerns as obstacles to studying abroad. Internationalisation-at-home has emerged as a viable alternative to mobility in Japan through government-funded internationalisation programs. This article will discuss the impact of cocurricular and extracurricular programs on the development of intercultural competence among 164 first-year Japanese students at two Top Global universities in Japan. Results from a one-year longitudinal, mixed methods study reveal that while formal programs positively affect intercultural competence development, informal intercultural contact on campus negatively affects students’ intercultural attitudes. Findings also indicate that student perceptions of intercultural competence at the pre-intervention stage affect engagement with intercultural opportunities on campus, suggesting the importance of introducing interventions prior to higher education.
Cleft Size and Success of Secondary Alveolar Bone Grafting—A Systematic Review
Authors: Chetpakdeechit Woranuch , Pisek Poonsak , Pitiphat Waranuch , Rattanakanokchai Siwanon
Published: December 2021

Objective

This study aimed to review all research evidence of presurgical cleft size and related factors to success of secondary alveolar bone grafting (SABG).

Design and Setting

The systematic review searched the OVID-Medline®, PubMed®, Embase®, and Cochrane Central Register of Controlled Trials (CENTRAL) up to August 2020. Two reviewers independently selected potential abstracts for full review. Disagreeements were resolved by consensus. The first author extracted data and assessed the risk of bias using Risk of Bias in Non-randomized studies—of Interventions tool.

Patients and Interventions

Patients with non-syndromic clefts who received SABG were selected. Presurgical cleft size/volume and treatment results must be available.

Main Outcome Measures

Level of the grafted bone, achievement of orthodontic tooth movement into the grafted area, need for re-operation.

Results

From 962 abstracts, 23 publications were included. Mean cleft width was 6.80 ± 1.98 mm, cleft area 20–240 mm2, and mean volume 0.89 ± 0.33 cm3. No definite conclusion was achieved on whether a narrow or wide cleft showed better treatment outcomes, but other potentially related factors were good oral hygiene and eruptive force of the maxillary canines. Lack of a standard definition of cleft size, a small sample size, varying outcome parameters, and moderate-to-high risk of bias contributed to the summary. A meta-analysis could not be performed because of the heterogeneity.

Conclusion

Due to insufficient evidence, cleft width/volume could not be specified leading to more successful SABG. Care of patients could be improved in both research by following rigorous methodology, and practice by clear communication.
Repair of Protruding Bilateral Cleft Lip and Palate With Staged Premaxilla Setback Osteotomy, Cheiloplasty, and Palatoplasty in Trisomy 17p Patient: A Review of Syndromic Clinical Characteristic
Authors: Bangun Kristaninta , Halim Jessica , Tania Vika
Published: December 2021

Chromosome 17 duplication is correlated with an increased risk of developmental delay, birth defects, and intellectual disability. Here, we reported a female patient with trisomy 17 on the whole short arm with bilateral complete cleft lip and palate (BCLP). This study will review the surgical strategies to reconstruct the protruding premaxillary segment, cleft lip, and palate in trisomy 17p patient.

The patient had heterozygous pathogenic duplication of chromosomal region chr17:526-18777088 on almost the entire short arm of chromosome 17. Beside the commonly found features of trisomy 17p, the patient also presented with BCLP with a prominent premaxillary portion. Premaxillary setback surgery was first performed concomitantly with cheiloplasty. The ostectomy was performed posterior to the vomero-premaxillary suture (VPS). The premaxilla was firmly adhered to the lateral segment and the viability of philtral flap was not compromised. Two-flap palatoplasty with modified intravelar veloplasty (IVV) was performed 4 months after.

Successful positioning of the premaxilla segment, satisfactory lip aesthetics, and vital palatal flap was obtained from premaxillary setback, primary cheiloplasty, and subsequent palatoplasty in our trisomy 17p patient presenting with BLCP. Postoperative premaxillary stability and patency of the philtral and palatal flap were achieved. Longer follow-up is needed to evaluate the long-term effects of our surgical techniques on inhibition of midfacial growth. However, the benefits that the patient received from the surgery in improving feeding capacity and facial appearance early in life outweigh the cost of possible maxillary retrusion.
Racial and Ethnic Disparities in Primary Cleft Lip and Cleft Palate Repair
Authors: Mullen Mary Carter , Yan Flora , Ford Marvella E. , Patel Krishna G. , Pecha Phayvanh P.
Published: December 2021

Objective

To examine the impact of race/ethnicity on timing and postoperative outcomes of primary cleft lip (CL) and cleft palate (CP) repair.

Design

Cross-sectional analysis of the National Surgical Quality Improvement Program Pediatric (NSQIP-P) database from 2013 to 2018.

Patients and main outcome measures

Patients under 2 years of age who underwent primary CL or CP repair were identified in the NSQIP-P. Outcomes were the timing of surgery and 30-day readmission and reoperation rates stratified by race and ethnicity.

Results

In total, 6021 children underwent CL and 6938 underwent CP repair. Adjusted rates of CL repair over time were 10% lower in Hispanic children (95%CI: 0.84–0.96) and 38% lower for Asian children (95%CI: 0.55–0.70) compared with White infants. CP repair rates over time were 13% lower in Black (95%CI: 0.79–0.95), 17% lower in Hispanic (95%CI: 0.77–0.89), and 53% lower in Asian children (95%CI: 0.43–0.53) than in White infants. Asian patients had the highest rates of delayed surgical repair, with 19.3% not meeting American Cleft Palate-Craniofacial Association (ACPA) guidelines for CL ( P < .001) and 28.2% for CP repair ( P< .001). Black and Hispanic children had 80% higher odds of readmission following primary CL repair (95%CI: 1.16–2.83 and 95%CI: 1.27–2.61, respectively).

Conclusions

This study of a national database identified several racial/ethnic disparities in primary CL and CP, with reduced receipt of cleft repair over time for non-White children. Asian patients were significantly more likely to have delayed cleft repair per ACPA guidelines. These findings underscore the need to better understand disparities in cleft repair timing and postoperative outcomes.
Harm and Helmets: How Harmful Social Costs Fail to Justify Paternalistic Health and Safety Regulations
Authors: Christensen Devin J.
Published: December 2021

Mill’s harm principle and the financial externalities of risky behavior are routinely invoked to justify health and safety regulation. However, this approach fares poorly when subjected to theoretical scrutiny. First, it is false: individuals engaging in risky behavior do not harm others. Second, even if risky behavior were harmful to others, the argument from harmful externalities does not imply safety-enhancing policy interventions, at least not without additional appeals to paternalism. Third, focusing on the economic impacts of accidents invites perverse victim-blaming attitudes toward accident victims that undermine democratic values and justice. To improve our moral understanding of health and safety regulation, I sketch a theory of public policy justification grounded in the controversies which attract our attention to paternalistic polices in the first place. On this account, justificatory arguments are plausible if they identify goods that individuals genuinely affirm on their own terms, are sensitive to causal responsibility and imbalances between restraint and protection, and comparatively engage with possible policy alternatives. Illustrating the shortcomings of one dominant approach to public policy justification and reorienting us toward the controversies that policy justifications need to confront reflect two ways that political theory can help enhance justice in public policy design and articulation.
Perceptions of Common Rape: How Rape Myth Acceptance, Victim Gender, and Victim Resistance Affect Victim and Perpetrator Blame Attributions in Party Rape and Date Rape
Authors: St. George Suzanne
Published: December 2021

Among rape perception studies, common types of male rape remain understudied. Using a randomized vignette design, I sampled 622 college students from a large Southwestern university to examine how victim gender and victim resistance influence blame attributions in party rape and date rape. Results revealed important interactions between victim gender, victim resistance, and rape type. Among other effects, resistance only affected victim blame in date rapes involving male victims. Results indicated that how respondents perceive victim and perpetrator responsibility, and which factors influence these perceptions, vary across rape type and victim gender. Implications for the rape perception literature are discussed.
The Place of Inspiration in Heritage Interpretation: Views From the Field
Authors: Gilson Jacquline , Kool Richard
Published: December 2021

While the idea of inspiration spans the history of the field, inspiration as a topic has been an under-studied phenomenon in the interpretation field. Thirty-three professional interpreters from 21 agencies across North America participated in dialog on the topic of inspiration in interpretation through Internet-based World Café sessions. The dialog was rich and thoughtful, and revealed that these interpreters believed that inspiration is the goal of interpretation and that the nine characteristics of inspiration identified in the literature and reviewed in our prior publication were relevant to interpretation: that inspiration is two-sided, transmissible, positive, individual, transcendent, unexpected, holistic, requires receptivity, and receptivity may be cultivated. Identified barriers to using an inspiration-based approach in interpretation included meeting the needs of agencies, and particularly the agency’s needs for quantitative measurements of attendance and impacts.
Axillary vein catheterization using ultrasound guidance: A prospective randomized cross-over controlled simulation comparing standard ultrasound and new needle-pilot device
Authors: Boulet Nicolas , Bobbia Xavier , Gavoille Antoine , Louart Benjamin , Lefrant Jean Yves , Roger Claire , Muller Laurent
Published: December 2021

Background:

Real-time ultrasound (US) guidance facilitates central venous catheterization in intensive care unit (ICU). New magnetic needle-pilot devices could improve efficiency and safety of central venous catheterization. This simulation trial was aimed at comparing venipuncture with a new needle-pilot device to conventional US technique.

Methods:

In a prospective, randomized, simulation trial, 51 ICU physicians and residents cannulated the right axillary vein of a human torso mannequin with standard US guidance and with a needle-pilot system, in a randomized order. The primary outcome was the time from skin puncture to successful venous cannulation. The secondary outcomes were the number of skin punctures, the number of posterior wall puncture of the axillary vein, the number of arterial punctures, the number of needle redirections, the failure rate, and the operator comfort.

Results:

Time to successful cannulation was shorter with needle-pilot US-guided technique (22 s (interquartile range (IQR) = 16–42) vs 25 s (IQR = 19–128); median of difference (MOD) = −9 s (95%-confidence interval (CI) −5, −22), p < 0.001). The rates of skin punctures, posterior wall puncture of axillary vein, and needle redirections were also lower ( p < 0.01). Comfort was higher in needle-pilot US-guided group on a 11-points numeric scale (8 (IQR = 8–9) vs 6 (IQR = 6–8), p < 0.001).

Conclusions:

In a simulation model, US-guided axillary vein catheterization with a needle-pilot device was associated with a shorter time of successful cannulation and a decrease in numbers of skin punctures and complications. The results plea for investigating clinical performance of this new device.
Compliance and resistance: How performance measures make and unmake universities
Authors: Soin Kim , Huber Christian
Published: December 2021

How individuals comply with, and resist performance measures and metrics can be seen as a key concern in management and organization. Recent literature has advanced our understanding of compliance as a social practice which is often related to resistance. Yet, compliance is seen as something we equate with simply yielding to power without any agency. We address this theme with a study of the effects of managerialism on academic work. More specifically, we investigate the introduction of measures and controls to improve PhD completion times in a research-intensive UK university. Our findings show that despite most of our respondents voicing concerns about the reductionist nature of the target and the consequences for quality, the large majority of academics we talked to complied with the measure. We identify three compliance types that demonstrate compliance is an interpretative process. We make two principal contributions with this paper. First, we offer insights into why compliance deserves analytic attention as a social practice in its own right, as something that goes beyond mere consent. Second, we analyze the impact of managerialism on higher education through the lens of compliance. We use these insights to reflect on how compliance was linked to resistance and the effects of different compliance practices on academic work which ranged from shifting responsibilities to challenging academic integrity.
Development of aerostatic porous bearings manufactured using metal 3D printing technology
Authors: Sadahiro Ryo , Nakayama Syota , Kawada Shouhei , Miyatake Masaaki , Sasaki Shinya , Yoshimoto Shigeka
Published: December 2021

Aerostatic porous bearings have been applied widely in precision devices to achieve higher accuracy of motion. Conventional aerostatic porous bearings are made of porous graphite, porous ceramics or sintered metal porous material, having a thickness of several millimetres and a surface-restricted layer. However, during mass production of porous bearings, the time required for the production of the porous materials and the surface restriction treatment leads to an increase in the manufacturing time and cost of the porous bearings. Accordingly, to overcome this problem, an aerostatic porous bearing with a layer thickness of several hundred µm and a support member, manufactured using metal 3D printing technology, is proposed. In this study, the optimum conditions for manufacturing the proposed aerostatic porous bearings with a direct metal laser sintering method 3D printer were investigated, and characteristics of the prototype of the proposed bearings were investigated experimentally.
Traffic noise attenuation solutions for naturally ventilated classrooms in South Africa
Authors: van Reenen Coralie , du Plessis Chrisna
Published: December 2021

Traffic noise transmission through the open windows of naturally-ventilated classrooms can reduce speech intelligibility and can negatively impact academic performance. The findings of a numerical study are presented. Software was used to assess effective noise attenuation solutions for naturally-ventilated classrooms exposed to traffic noise. A typical situation in urban schools in Gauteng, South Africa, is considered in which classrooms are ventilated by large open windows in accordance with national building regulations and norms and standards for school design. The aim of the study was to establish a heuristic framework for early design decisions regarding how far from the road a classroom building should be set, and the effective height and position of a solid noise barrier to ensure a suitable ambient noise level inside a classroom with open windows. Efficacy was measured with reference to an indoor ambient sound level of 40 dBA. The findings show that with the insertion of barriers, the required ambient level was achieved for a classroom at least 68 m from the road, if the barrier is at least 3.5 m high. However, it was found that a significant insertion loss (>6 dB) and an improved signal to noise ratio could be achieved for classrooms as close as 17 m from the road with a barrier of at least 2 m high. Though not broadly generalizable, the findings provide a heuristic guide applicable for designing new schools or selecting attenuation interventions in existing city schools that are similar to those used in the study.
Absence of attack-independent neuroaxonal injury in MOG antibody-associated disease: Longitudinal assessment of serum neurofilament light chain
Authors: Hyun Jae-Won , Kim So Yeon , Kim Yeseul , Park Na Young , Kim Ki Hoon , Kim Su-Hyun , Kim Ho Jin
Published: December 2021

To evaluate the occurrence of attack-independent neuroaxonal and astrocytic damage in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) levels were longitudinally measured in 102 sera using a single-molecule array assay. Sera from 15 adults with relapsing MOGAD with available longitudinal samples for the median 24-month follow-up and 26 age-/sex-matched healthy controls were analyzed. sNfL levels were significantly elevated in all clinical attacks, where the levels decreased below or close to cut-off value within 6 months after attacks. sNfL levels were consistently low during inter-attack periods. In contrast, sGFAP levels did not increase in most clinical attacks and remained low during follow-up. Significant neuroaxonal damage was observed at clinical attacks, while attack-independent neuroaxonal and astrocytic injury was absent in MOGAD.