bluuebunny/crossref_metadata_2025 huggingface dataset:
Fractional Variability—A Tool to Study Blazar Variability
Authors: Schleicher Bernd , Arbet-Engels Axel , Baack Dominik , Balbo Matteo , Biland Adrian , Blank Michael , Bretz Thomas , Bruegge Kai , Bulinski Michael , Buss Jens , Doerr Manuel , Dorner Daniela , Elsaesser Dominik , Grischagin Sergej , Hildebrand Dorothee , Linhoff Lena , Mannheim Karl , Mueller Sebastian , Neise Dominik , Neronov Andrii , Noethe Maximilian , Paravac Aleksander , Rhode Wolfgang , Schulz Florian , Sedlaczek Kevin , Shukla Amit , Sliusar Vitalii , Willert Elan , Walter Roland
Published: May 2019

Active Galactic Nuclei emit radiation over the whole electromagnetic spectrum up to TeV energies. Blazars are one subtype with their jets pointing towards the observer. One of their typical features is extreme variability on timescales, from minutes to years. The fractional variability is an often used parameter for investigating the degree of variability of a light curve. Different detection methods and sensitivities of the instruments result in differently binned data and light curves with gaps. As they can influence the physics interpretation of the broadband variability, the effects of these differences on the fractional variability need to be studied. In this paper, we study the systematic effects of completeness in time coverage and the sampling rate. Using public data from instruments monitoring blazars in various energy ranges, we study the variability of the bright TeV blazars Mrk 421 and Mrk 501 over the electromagnetic spectrum, taking into account the systematic effects, and compare our findings with previous results. Especially in the TeV range, the fractional variability is higher than in previous studies, which can be explained by the much longer (seven years compared to few weeks) and more complete data sample.
From a Christian World Community to a Christian America: Ecumenical Protestant Internationalism as a Source of Christian Nationalist Renewal
Authors: Edwards Mark
Published: May 2019

Christian nationalism in the United States has neither been singular nor stable. The country has seen several Christian nationalist ventures come and go throughout its history. Historians are currently busy documenting the plurality of Christian nationalisms, understanding them more as deliberate projects rather than as components of a suprahistorical secularization process. This essay joins in that work. Its focus is the World War II and early Cold War era, one of the heydays of Christian nationalist enthusiasm in America—and the one that shaped our ongoing culture wars between “evangelical” conservatives and “godless” liberals. One forgotten and admittedly paradoxical pathway to wartime Christian nationalism was the world ecumenical movement (“ecumenical” here meaning intra-Protestant). Protestant ecumenism curated the transformation of 1920s and 1930s Christian internationalism into wartime Christian Americanism. They involved many political and intellectual elites along the way. In pioneering many of the geopolitical concerns of Cold War evangelicals, ecumenical Protestants aided and abetted the Christian conservative ascendancy that wields power even into the present.
Illness Narratives and Facebook: Living Illness Well
Authors: Hinson Katrina , Sword Ben
Published: May 2019

Earlier scholarship provides important insights into the relationship of individual stories and narratives. Interactions with healthcare professionals and the healthcare system can often subsume the individual’s authority/agency. The patient’s narrative often gets lost in the elaborate web of doctor visits, referrals, medical records, case notes, etc. Online spaces such as Facebook, however, provide individuals with a platform through which they can understand, craft, and communicate their own personal illness narratives. Realizing this, this paper examines how the narratives of illness shared in illness-related Facebook groups help individuals make sense out of the disruption caused by their personal experience while residing in the ‘kingdom of the ill.’ To observe the construction and communication of these narratives, the researchers observed the activity of an online pulmonary embolism and deep-vein thrombosis survivor support group for one year. In this online space, individuals gained agency and authority in the construction of their own illness narratives. The findings of the research demonstrated both the importance of narrative in an individual’s health/illness journey as well as the need to further explore avenues that establish and bolster patient agency within the medical system.
Research Advances in Identifying Sulfate Contamination Sources of Water Environment by Using Stable Isotopes
Authors: Wang Huiwei , Zhang Qianqian
Published: May 2019

As the main anion of groundwater, the content of sulfate affects the drinking water safety and ecological security directly. In recent years, with the acceleration of industrialization and urbanization development, the problem of sulfate pollution in water environments is becoming more and more serious. It is critical to effectively identify the sulfate sources of water environment to ensure human health and the benign evolution of water environment. Due to its “fingerprints” feature, the sulfur and oxygen isotopes of SO42− have been widely used to identify sources of sulfate contamination in water environment. However, research advances in tracing sulfate contamination sources of water environment by using stable isotopes are rarely reported. This paper reviewed the research advances of sulfate isotope technology domestically and abroad, which was used to trace the sources of sulfate pollution in water environment, compared different pre-treatment methods for analyzing the δ34S and δ18O of sulfate, and compiled the ranges of typical values of δ34S and δ18O from different potential sources of sulfate contamination. In this review, the limitation of the technique in traceability of sulfate pollution was also discussed, and the future traceability techniques of sulfate pollution were prospected.
Multidimensional Web GIS Approach for Citizen Participation on Urban Evolution
Authors: Lafrance Frederick , Daniel Sylvie , Dragićević Suzana
Published: May 2019

Web-mapping has been widely used to facilitate citizen participation in smart cities. Web-mapping has evolved from 2D static maps towards more dynamic and immersive 3D worlds such as virtual globes and scenes. Although current technologies allow us to build multidimensional representations, there is still a lack of research studies on how to further leverage them to foster citizen participation. Information on space–time changes can be an important asset for a successful citizen participation process. Citizens may need to track the evolution of their city over space and time, and how their participation will impact the urban planning and decision-making process. Consequently, the main objective of this research study is to design and develop a multidimensional (2D, 3D, 4D) web-mapping platform where citizens can better assess and understand the spatiotemporal evolution of their cities. User testing was conducted to assess the multidimensional representation of the animations used, and the spatiotemporal mechanism and interface features. Results showed that it is recommended to integrate spatiotemporal simulations to citizen participation platforms so citizens can better assess the impacts of their choices. We also assessed that 3D does not always communicate information better than 2D. Future work will aim at testing the platform in a consultation process with a representative sample of participants.
Knowledge Embedding with Geospatial Distance Restriction for Geographic Knowledge Graph Completion
Authors: Qiu Peiyuan , Gao Jialiang , Yu Li , Lu Feng
Published: May 2019

A Geographic Knowledge Graph (GeoKG) links geographic relation triplets into a large-scale semantic network utilizing the semantic of geo-entities and geo-relations. Unfortunately, the sparsity of geo-related information distribution on the web leads to a situation where information extraction systems can hardly detect enough references of geographic information in the massive web resource to be able to build relatively complete GeoKGs. This incompleteness, due to missing geo-entities or geo-relations in GeoKG fact triplets, seriously impacts the performance of GeoKG applications. In this paper, a method with geospatial distance restriction is presented to optimize knowledge embedding for GeoKG completion. This method aims to encode both the semantic information and geospatial distance restriction of geo-entities and geo-relations into a continuous, low-dimensional vector space. Then, the missing facts of the GeoKG can be supplemented through vector operations. Specifically, the geospatial distance restriction is realized as the weights of the objective functions of current translation knowledge embedding models. These optimized models output the optimized representations of geo-entities and geo-relations for the GeoKG’s completion. The effects of the presented method are validated with a real GeoKG. Compared with the results of the original models, the presented method improves the metric Hits@10(Filter) by an average of 6.41% for geo-entity prediction, and the Hits@1(Filter) by an average of 31.92%, for geo-relation prediction. Furthermore, the capacity of the proposed method to predict the locations of unknown entities is validated. The results show the geospatial distance restriction reduced the average error distance of prediction by between 54.43% and 57.24%. All the results support the geospatial distance restriction hiding in the GeoKG contributing to refining the embedding representations of geo-entities and geo-relations, which plays a crucial role in improving the quality of GeoKG completion.
Revealing Spatial-Temporal Characteristics and Patterns of Urban Travel: A Large-Scale Analysis and Visualization Study with Taxi GPS Data
Authors: Wang Huihui , Huang Hong , Ni Xiaoyong , Zeng Weihua
Published: May 2019

Mobility and spatial interaction data have become increasingly available due to the widespread adoption of location-aware technologies. Examples of mobile data include human daily activities, vehicle trajectories, and animal movements. In this study we focus on a special type of mobility data, i.e., origin–destination (OD) pairs, and propose a new adapted chord diagram plot to reveal the urban human travel spatial-temporal characteristics and patterns of a seven-day taxi trajectory data set collected in Beijing; this large scale data set includes approximately 88.5 million trips of anonymous customers. The spatial distribution patterns of the pick-up points (PUPs) and the drop-off points (DOPs) on weekdays and weekends are analyzed first. The maximum of the morning and the evening peaks are at 8:00–10:00 and 17:00–19:00. The morning peaks of taxis are delayed by 0.5–1 h compared with the commuting morning peaks. Second, travel demand, intensity, time, and distance on weekdays and weekends are analyzed to explore human mobility. The travel demand and high-intensity travel of residents in Beijing is mainly concentrated within the 6th Ring Road. The residents who travel long distances (>10 km) and for a long time (>60 min) mainly from outside the 6th Ring Road and the surrounding new towns of Beijing. The circular structure of the travel distance distribution also confirms the single-center urban structure of Beijing. Finally, a new adapted chord diagram plot is proposed to achieve the spatial-temporal scale visualization of taxi trajectory origin–destination (OD) flows. The method can characterize the volume, direction, and properties of OD flows in multiple spatial-temporal scales; it is implemented using a circular visualization package in R (circlize). Through the visualization experiment of taxi GPS trajectory data in Beijing, the results show that the proposed visualization technology is able to characterize the spatial-temporal patterns of trajectory OD flows in multiple spatial-temporal scales. These results are expected to enhance current urban mobility research and suggest some interesting avenues for future research.
Role of NF-kB RelB in Aryl Hydrocarbon Receptor-Mediated Ligand Specific Effects
Authors: Ishihara Yasuhiro , Kado Sarah Y. , Hoeper Christiane , Harel Shelly , Vogel Christoph F. A.
Published: May 2019

Here, we investigate the role of RelB in the regulation of genes which were identified to be induced in an aryl hydrocarbon receptor (AhR)-dependent manner and critically involved in regulation of immune responses. We analyzed the expression of genes of the AhR gene battery, cytokines, and immune regulatory enzymes in bone marrow-derived macrophages (BMM) and thymus of B6 wildtype (wt) mice and RelB knockout (RelB−/−) mice after treatment with various AhR ligands. The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced expression of indoleamine 2,3-dioxygenase 1 (IDO1) and IDO2 was significantly repressed in thymus of RelB−/− mice but not in BMM derived from RelB−/− mice. Interestingly, the induced and basal expression of the cytokines interleukin (IL)-17A, IL-22, and CCL20 required the functional expression of RelB. The RelB-dependent expression of CCL20 was induced by the AhR ligands TCDD and 6-formylindolo[3,2-b]carbazole (FICZ), whereas indole-3-carbinol (I3C) suppressed CCL20 in lipopolysaccharide (LPS)-activated wt BMM. The LPS-induced expression of IL-6 and IL-10 was enhanced by TCDD and FICZ, whereas I3C significantly suppressed these cytokines in BMM. The exposure to FICZ led to higher increases of IL-17A and IL-22 mRNA compared to the effect of TCDD or I3C in thymus of wt mice. On the other hand, TCDD was the strongest inducer of CYP1A1, AhR Repressor (AhRR), and IDO2. In summary, these findings provide evidence for the important role of RelB in the transcriptional regulation of cytokines and enzymes induced by AhR ligands.
Activity of Carbonic Anhydrase VI is Higher in Dental Biofilm of Children with Caries
Authors: Picco Daniele C. R. , Marangoni-Lopes Lenita , Parisotto Thaís M. , Mattos-Graner Renata , Nobre-dos-Santos Marinês
Published: May 2019

This study investigated pH, activity and concentration of carbonic anhydrase VI (CA VI) in dental biofilm of caries and caries-free children of 7–9 years old. Seventy-four children were selected and divided into two groups. The caries diagnosis was performed according to the WHO criteria, including the early caries lesion. After biofilm collection and pH determination, CA VI concentration and activity were determined by ELISA and Zimography respectively. The data were submitted to a Mann-Whitney test and to Pearson and Spearman correlation analyses. Means and standard deviations of dental caries for the caries group were of 3.162 ± 1.385. The biofilm pH was significantly higher in the caries-free group. The CA VI activity was significantly higher in biofilm of children with caries. The CA VI concentration was significantly higher in biofilm of caries-free children. In caries-free children, there was a moderate negative correlation between CA VI activity and concentration in dental biofilm as well as between pH and CA VI activity. A negative correlation between biofilm pH and CA VI concentration was found in the caries group. In conclusion, CA VI was shown to be more active in the biofilm of school children with caries in order to contribute to neutralization of biofilm acid.
Green Investment Decisions in Supply Chains: A Game Model with Complete Information
Authors: Li Qiuzheng , Zhang Zuopeng (Justin) , Rao Wei , Xu Wenwen , Jiang Lijia
Published: May 2019

Prior literature on a two-level supply chain has mainly focused on the game between one manufacturer and one supplier. Exploring group game behavior in a green supply chain (GSC), our research develops and studies a sequential GSC game model consisting of a single manufacturer and three suppliers based on the characteristics of the textile and apparel industry clusters. In our GSC model, the manufacturer is the leader of the supply chain and the suppliers are either homogeneous or complementary. Through equilibrium analysis, we identify critical conditions that influence the behavior of the manufacturer and suppliers to improve the green investment in the supply chain. Our study provides a theoretical basis and a decision-making reference for promoting the cooperation in GSCs and improving the performance of the government’s environmental policies.
Hybrid Coronary Percutaneous Treatment with Metallic Stents and Everolimus-Eluting Bioresorbable Vascular Scaffolds: 2-Years Results from the GABI-R Registry
Authors: Gori Tommaso , Achenbach Stephan , Riemer Thomas , Mehilli Julinda , Nef Holger M. , Naber Christoph , Richardt Gert , Wöhrle Jochen , Zahn Ralf , Neumann Till , Kastner Johannes , Schmermund Axel , Hamm Christian , Münzel Thomas
Published: May 2019

The limitations of the first-generation everolimus-eluting coronary bioresorbable vascular scaffolds (BVS) have been demonstrated in several randomized controlled trials. Little data are available regarding the outcomes of patients receiving hybrid stenting with both BVS and drug-eluting stents (DES). Of 3144 patients prospectively enrolled in the GABI-Registry, 435 (age 62 ± 10, 19% females, 970 lesions) received at least one BVS and one metal stent (hybrid group). These patients were compared with the remaining 2709 (3308 lesions) who received BVS-only. Patients who had received hybrid stenting had more frequently a history of cardiovascular disease and revascularization (p < 0.05), had less frequently single-vessel disease (p < 0.0001), and the lesions treated in these patients were longer (p < 0.0001) and more frequently complex. Accordingly, the incidence of periprocedural myocardial infarction (p < 0.05) and that of cardiovascular death, target vessel and lesion failure and any PCI at 24 months was lower in the BVS-only group (all p < 0.05). The 24-months rate of definite and probable scaffold thrombosis was 2.7% in the hybrid group and 2.8% in the BVS-only group, that of stent thrombosis in the hybrid group was 1.86%. In multivariable analysis, only implantation in bifurcation lesions emerged as a predictor of device thrombosis, while the device type was not associated with this outcome (p = 0.21). The higher incidence of events in patients receiving hybrid stenting reflects the higher complexity of the lesions in these patients; in patients treated with a hybrid strategy, the type of device implanted did not influence patients´ outcomes.
Relation between Weight Status, Physical activity, Maturation, and Functional Movement in Adolescence: An Overview
Authors: Karuc Josip , Mišigoj-Duraković Marjeta
Published: May 2019

Obesity, low level of physical activity and dysfunctional movement patterns presents one of the leading health issues that can contribute to increased risk for developing not only metabolic and cardiovascular disease, but also musculoskeletal problems. The aim of this paper is to summarize literature and evidence about relationship between functional movement (FM) patterns, physical activity (PA) level and weight status in average adolescent population. In addition, this paper summarized current evidence about relations between maturation effects and functional movement among athletic adolescent populations. Summary of current evidence suggests that decreased physical activity level is negatively correlated to functional movement in adolescence. Additionally, most studies suggest that weight status is negatively correlated to functional movement patterns although there is conflicting evidence in this area. Evidence consistently showed that overweight and obese adolescents exhibit poorer functional movement compared to normal weight adolescents. In addition, it appears that maturation has effects on functional movement in athletic populations of adolescents. It is therefore important that practitioners consider interventions which develop optimal functional movement alongside physical activity and weight management strategies in children, in order to reduce the risks of injuries and pathological abnormality arising from suboptimal movement patterns in later life.
Optimization of Cathodic Protection Design for Pre-Insulated Pipeline in District Heating System Using Computational Simulation
Authors: Hong Min-Sung , So Yoon-Sik , Kim Jung-Gu
Published: May 2019

Cathodic protection (CP) has been used as a primary method in the control of corrosion, therefore it is regarded as the most effective way for protecting buried pipelines. However, it is difficult to apply CP to a pipeline for district heating distribution systems, because the pipeline has thermally insulated coatings which could disturb the CP. Theoretical calculation and field tests alone are not enough for a reliable CP design, and therefore additional CP design methods such as computational analysis should be used. In this study, the CP design for pre-insulated pipelines is tested considering several environmental factors, such as temperature and coating defect ratio. Additionally, computational analysis is performed to verify and optimize the CP design. The simulation results based on theoretical methods alone failed to satisfy the CP criteria. Then, a re-design is conducted considering the IR drop. Consequently, all of the simulation results of defective pipelines satisfied the CP criteria after adding the proper CP current.
C-MAC Video Laryngoscope versus Conventional Direct Laryngoscopy for Endotracheal Intubation During Cardiopulmonary Resuscitation
Authors: Min Byeong Chul , Park Jong Eun , Lee Gun Tak , Kim Tae Rim , Yoon Hee , Cha Won Chul , Shin Tae Gun , Song Keun Jeong , Park Minsu , Han Heewon , Hwang Sung Yeon
Published: May 2019

Background and objectives: To compare the first pass success (FPS) rate of the C-MAC video laryngoscope (C-MAC) and conventional Macintosh-type direct laryngoscopy (DL) during cardiopulmonary resuscitation (CPR) in the emergency department (ED). Materials and Methods: This study was a single-center, retrospective study conducted from April 2014 to July 2018. Patients were categorized into either the C-MAC or DL group, according to the device used on the first endotracheal intubation (ETI) attempt. The primary outcome was the FPS rate. A multiple logistic regression model was developed to identify factors related to the FPS. Results: A total of 573 ETIs were performed. Of the eligible cases, 263 and 310 patients were assigned to the C-MAC and DL group, respectively. The overall FPS rate was 75% (n = 431/573). The FPS rate was higher in the C-MAC group than in the DL group, but there was no statistically significant difference (total n = 431, 79% compared to 72%, p = 0.075). In the multiple logistic regression analysis, the C-MAC use had higher FPS rate (adjusted odds ratio: 1.80; 95% CI, 1.17–2.77; p = 0.007) than that of the DL use. Conclusions: The C-MAC use on the first ETI attempt during cardiopulmonary resuscitation in the emergency department had a higher FPS rate than that of the DL use.
Clinicians’ Perceived Understanding of Biostatistical Results in the Medical Literature: A Cross-Sectional Study
Authors: Ganasegeran Kurubaran , Ch’ng Alan Swee Hock , Jamil Mohd Fadzly Amar , Looi Irene
Published: May 2019

Background and objectives: The continuum of evidence-based medicine (EBM) depends solely on clinicians’ commitment to keep current with the latest clinical information. Exploration on clinicians’ understanding of biostatistical results in the medical literature is sparse to date. This study aimed to evaluate clinicians’ perceived understanding of biostatistical results in the medical literature and the factors influencing them. Materials and Methods: A cross-sectional study was conducted among 201 clinicians at the Seberang Jaya Hospital, a cluster-lead research hospital in Northern Malaysia. A self-administered questionnaire that consisted of items on sociodemographics, validated items on clinicians’ confidence level in interpreting statistical concepts, perceived understanding of biostatistics, and familiarity with different statistical methods were used. Descriptive, univariate, and multivariate analyses were conducted. Results: Perceived understanding of biostatistical results among clinicians in our sample was nearly 75%. In the final regression model, perceived understanding was significantly higher among clinicians who were able to interpret p-values with complete confidence (AOR = 3.0, 95% CI 1.1–8.1), clinicians who regularly encounter measures of central tendencies (AOR = 2.3, 95% CI 1.1–5.2), and clinicians who regularly encounter inferential statistics (AOR = 2.2, 95% CI 1.1–4.5) while appraising the medical literature. Conclusions: High perceived understanding was significantly associated with clinicians’ confidence in interpreting statistical concepts and familiarity with different statistical methods. Our findings form a platform to understand clinicians’ ability to appraise rigorous biostatistical results in the medical literature for the retrieval of evidence-based data to be used in routine clinical practice.
Evaluation of Atrial Electromechanical Delay in Children with Obesity
Authors: Temiz Fatih , Güneş Hatice , Güneş Hakan
Published: May 2019

Background and Objective: Childhood obesity is one of the worldwide health problems with an increasing prevalence and accompanied by severe morbidity and mortality. It is a serious predisposing risk factor especially for the development of cardiovascular diseases and arrhythmias. Electromechanical delay (EMD) is known to be a predictor for the development of atrial fibrillation (AF). Our study aims to investigate whether EMD, which is a predictor of AF, prolongs in obese children or not. Material and Methods: The study included 59 obese patients aged between 8–18 years and 38 healthy patients as the control group with a similar age and gender. All the individuals underwent transthoracic echo and tissue Doppler echocardiography. Systolic and diastolic left ventricular (LV) functions, inter- and intra-atrial electromechanical delay were measured by tissue Doppler imaging (TDI) and conventional echocardiography. Results: Obese patients had significantly lengthened P-wave on surface ECG to the beginning of the late diastolic wave (PA) lateral, PA septum, intra- and inter-atrial electromechanical delays when compared with the control group (p < 0.001, p = 0.001, p < 0.001 and p < 0.001, respectively) Inter-atrial EMD and intra-atrial EMD correlated positively with body mass index (BMI) values (r = 0.484, p < 0.001 and r = 0.376, p = 0.001; respectively) BMI was significantly related with inter-atrial EMD (β = 0.473, p < 0.001) However, there was no relationship between inter-atrial EMD and serum glucose and platelet count. Conclusion: In our study, we declared that electromechanical delay was increased in obese children when compared to the control group and intra- and inter-atrial electromechanical delay was in correlation with body mass index. Furthermore, we discovered that BMI is an independent predictor of the inter-atrial EMD in obese children.
Dynamic Mechanical Behavior and Microstructure Evolution of an Extruded 6013-T4 Alloy at Elevated Temperatures
Authors: Ye Tuo , Wu Yuanzhi , Liu Wei , Deng Bin , Liu Anmin , Li Luoxing
Published: May 2019

The mechanical properties of an extruded 6013-T4 alloy were tested at a temperature range from 25 to 400 °C and strain rate range from 1 × 103 to 5 × 103 s−1. The results demonstrate that the stress level is sensitive to strain rate and temperature. The stress level increases slightly with increasing strain rate and decreases remarkably with increasing temperature. The dislocation and precipitate undergo great changes. When deformed at 25 °C, the density of the dislocation increases with strain and strain rate; which leads to a higher stress level. A great number of needle-like precipitates were observed at samples deformed at 200 °C. It is clear that the density of dislocation increases with strain and strain rate. When impacted at 400 °C, the coarser precipitates were found in the specimen; the density of the dislocation increases with strain and strain rate.
Effects of Prebending Radii on Microstructure and Fatigue Performance of Al-Zn-Mg-Cu Aluminum Alloy after Creep Age Forming
Authors: Yang Dalian , Miao Jingjing , Zhang Fanyu , Fu Zhuo , Liu Yilun
Published: May 2019

A series of creep age forming experiments were carried out on 7075 aluminum alloy with different prebending radii at 443 K for 10 h. The hardness, tensile properties and high cycle fatigue performance of the alloy after creep age forming were obtained. In addition, the microstructure and fatigue fracture of the alloy were observed by transmission electron microscopy (TEM) and scanning electron microscope (SEM). The results show that with the increase of the prebending radius, the hardness, strength and elongation of the alloy increased; meanwhile, the conditional fatigue limit increased, the size of precipitated phase decreased and the quantity increased, while the width of precipitate free zone decreased.
Geometrical Representation of a Polarisation Management Component on a SOI Platform
Authors: Preite Massimo Valerio , Sorianello Vito , De Angelis Gabriele , Romagnoli Marco , Velha Philippe
Published: May 2019

Grating couplers, widely used in Silicon Photonics (SiPho) for fibre-chip coupling are polarisation sensitive components, consequently any polarisation fluctuation from the fibre optical link results in spurious intensity swings. A polarisation management componentis analytically considered, coupled with a geometrical representation based on phasors and Poincaré sphere, generalising and simplifying the treatment and understanding of its functionalities. A specific implementation in SOI is shown both as polarisation compensator and polarisation controller, focusing on the operative principle. Finally, it is demonstrated experimentally that this component can be used as an integrated polarimeter.
Detection of Trace Elements/Isotopes in Olympic Dam Copper Concentrates by nanoSIMS
Authors: Rollog Mark , Cook Nigel J. , Guagliardo Paul , Ehrig Kathy , Ciobanu Cristiana L. , Kilburn Matt
Published: May 2019

Many analytical techniques for trace element analysis are available to the geochemist and geometallurgist to understand and, ideally, quantify the distribution of trace and minor components in a mineral deposit. Bulk trace element data are useful, but do not provide information regarding specific host minerals—or lack thereof, in cases of surface adherence or fracture fill—for each element. The CAMECA nanoscale secondary ion mass spectrometer (nanoSIMS) 50 and 50L instruments feature ultra-low minimum detection limits (to parts-per-billion) and sub-micron spatial resolution, a combination not found in any other analytical platform. Using ore and copper concentrate samples from the Olympic Dam mining-processing operation, South Australia, we demonstrate the application of nanoSIMS to understand the mineralogical distribution of potential by-product and detrimental elements. Results show previously undetected mineral host assemblages and elemental associations, providing geochemists with insight into mineral formation and elemental remobilization—and metallurgists with critical information necessary for optimizing ore processing techniques. Gold and Te may be seen associated with brannerite, and Ag prefers chalcocite over bornite. Rare earth elements may be found in trace quantities in fluorapatite and fluorite, which may report to final concentrates as entrained liberated or gangue-sulfide composite particles. Selenium, As, and Te reside in sulfides, commonly in association with Pb, Bi, Ag, and Au. Radionuclide daughters of the 238U decay chain may be located using nanoSIMS, providing critical information on these trace components that is unavailable using other microanalytical techniques. These radionuclides are observed in many minerals but seem particularly enriched in uranium minerals, some phosphates and sulfates, and within high surface area minerals. The nanoSIMS has proven a valuable tool in determining the spatial distribution of trace elements and isotopes in fine-grained copper ore, providing researchers with crucial evidence needed to answer questions of ore formation, ore alteration, and ore processing.
Carbon-Filled Organic Phase-Change Materials for Thermal Energy Storage: A Review
Authors: Yang Guijun , Yim Yoon-Ji , Lee Ji Won , Heo Young-Jung , Park Soo-Jin
Published: May 2019

Phase-change materials (PCMs) are essential modern materials for storing thermal energy in the form of sensible and latent heat, which play important roles in the efficient use of waste heat and solar energy. In the development of PCM technology, many types of materials have been studied, including inorganic salt and salt hydrates and organic matter such as paraffin and fatty acids. Considerable research has focused on the relationship between the material structure and energy storage properties to understand the heat storage/emission mechanism involved in controlling the energy storage performance of materials. In this study, we review the application of various carbon-filled organic PCMs in the field of heat storage and describe the current state of this research.
Seed Characteristics and Nutritional Composition of Pine Nut from Five Populations of P. cembroides from the States of Hidalgo and Chihuahua, Mexico
Authors: Valero-Galván José , Reyna-González Margarita , Chico-Romero Perla Anneth , Martínez-Ruiz Nina del Rocío , Núñez-Gastélum José Alberto , Monroy-Sosa Abigail , Ruiz-May Eliel , González Fernández Raquel
Published: May 2019

The aim of this study was to analyze the seed characteristics and nutritional composition of five pine nut P. cembroides samples from two Mexican states. Morphometry, proximal composition, phenolic compounds, and antioxidant capacity were determined. Samples differed in several morphometric trails, but important differences were documented between SMCH and JCZH samples from Hidalgo State. JCZH and FMH had the highest contents of water, lipids, protein, flavonoids, and antioxidant activity, while CMCC population from Chihuahua State had presented the highest content of ash and carbohydrates. Morphometry and chemical composition data were subjected to clustering analysis. This analysis showed that SMCH and LFCH from Hidalgo State were well separated from the JCZH and FMH populations from Hidalgo State, which showed a strong similarity between them, while the CMCC from Chihuahua State was the most distant population. Principal components analysis showed that the variables that strongly contributed to PC1 were the antioxidant activity determined by FRAP assay, flavonoids, and water content. These data have provided biochemical markers that could help to establish phylogenetic associations between populations, and also to reveal potentially account as an alternative source for dietary nutrition.
New Phenolic Derivatives of Thiazolidine-2,4-dione with Antioxidant and Antiradical Properties: Synthesis, Characterization, In Vitro Evaluation, and Quantum Studies
Authors: Marc Gabriel , Stana Anca , Oniga Smaranda Dafina , Pîrnău Adrian , Vlase Laurian , Oniga Ovidiu
Published: May 2019

Oxidative stress has been incriminated in the physiopathology of many diseases, such as diabetes, cancer, atherosclerosis, and cardiovascular and neurodegenerative diseases. There is a great interest in developing new antioxidants that could be useful for preventing and treating conditions for which oxidative stress is suggested as the root cause. The thiazolidine-2,4-dione derivatives have been reported to possess various pharmacological activities and the phenol moiety is known as a pharmacophore in many naturally occurring and synthetic antioxidants. Twelve new phenolic derivatives of thiazolidine-2,4-dione were synthesized and physicochemically characterized. The antioxidant capacity of the synthesized compounds was assessed through several in vitro antiradical, electron transfer, and Fe2+ chelation assays. The top polyphenolic compounds 5f and 5l acted as potent antiradical and electron donors, with activity comparable to the reference antioxidants used. The ferrous ion chelation capacity of the newly synthesized compounds was modest. Several quantum descriptors were calculated in order to evaluate their influence on the antioxidant and antiradical properties of the compounds and the chemoselectivity of the radical generation reactions has been evaluated. The correlation with the energetic level of the frontier orbitals partially explained the antioxidant activity, whereas a better correlation was found while evaluating the O–H bond dissociation energy of the phenolic groups.
Design, Synthesis, Antimicrobial, and Anticancer Activities of Acridine Thiosemicarbazides Derivatives
Authors: Chen Rui , Huo Lini , Jaiswal Yogini , Huang Jiayong , Zhong Zhenguo , Zhong Jing , Williams Leonard , Xia Xing , Liang Yan , Yan Zhenshuo
Published: May 2019

Background: Acridine and thiourea derivatives are important compounds in medicinal chemistry due to their diverse biological properties including anticancer and antimicrobial effects. However, literature reveals some side effects associated with use of acridines. It is suggested that hybrid molecules may reduce the side effects and enhance the beneficial properties due to synergistic activity. The objectives of the present study are to synthesize and evaluate the anticancer and antimicrobial properties of new hybrids of acridine thiosemicarbazides derivatives. Results: The structures of the synthesized compounds 4a–4e were elucidated by MS and NMR spectra. In antimicrobial assay, Compound 4c exhibited potent antimicrobial activity compared to the other four compounds. In anticancer studies, we observed that compounds 4a, 4b, 4d and 4e exhibited high cytotoxicity against the MT-4 cell line, with IC50 values of 18.42 ± 1.18, 15.73 ± 0.90, 10.96 ± 0.62 and 11.63 ± 0.11 μM, respectively. The evaluation of anticancer effects, and the associated mechanism reveals that, the anticancer activities may be related to Topo I inhibitory activity, apoptosis and cell-cycle. Molecular docking studies revealed that the presence of planar naphtho-fused rings and a flexible thiourea group together, could improve DNA-intercalation and inhibition of DNA-Topo I activity. Conclusions: The results of this study demonstrate that the rational design of target derivatives as novel antimicrobial or antitumor leads is feasible.
Tissue Distribution and Anti-Lung Cancer Effect of 10-Hydroxycamptothecin Combined with Platycodonis Radix and Glycyrrhizae Radix ET Rhizoma
Authors: Zhang Wugang , Li Mulan , Du Wendi , Yang Wuliang , Li Guofeng , Zhang Chen , Liang Xinli , Chen Haifang
Published: May 2019

10-Hydroxycamptothecin (HCPT) is a broad-spectrum chemotherapeutic drug, although its side effects and multidrug resistance (MDR) limit its clinical application. A range of drug delivery systems have been utilized to overcome its shortcomings and maintain its therapeutic efficacy, however the use of the transport effect of traditional Chinese medicines (TCMs) to improve the distribution of chemotherapeutic drugs has not been widely reported. Platycodonis Radix (JG) and Glycyrrhizae Radix ET Rhizoma (GC) are common TCMs in clinics and are often combined as drug pairs to act as “transport agents”. In the present study, the effect of JG and GC (JGGC) on the distribution of HCPT in tissues and its antitumor efficacy after being combined as a therapy were investigated, for which ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was used. Furthermore, the effect on the protein expression of multidrug resistance proteins (P-gp and LRP), and the immunomodulatory and synergistic antiapoptotic effect on Lewis lung cancer-bearing C57BL/6J mice were also evaluated. The results demonstrate that JGGC significantly increased the area under the concentration time curve (AUC) and mean residence time (MRT) and reduced the clearance rate (CL) of HCPT. In addition, the combined use of JGGC decreased the levels of LRP, P-gp and Bcl-2/Bax when treated with HCPT. JGGC also significantly elevated the levels of RBCs, PLTs, HGB, IL-2, and IFN-γ, and decreased IL-10 levels. In summary, an increased concentration of HCPT in tissues was observed when it was combined with JGGC through inhibition of efflux protein, with a synergistic enhancement of the anticancer effect observed through promotion of apoptosis and immunity due to a reversion of the Th1/Th2 shift. Our findings provide a reference for the feasibility of combining JGGC with chemotherapy drugs in clinical applications.
Anti-Candida Biofilm Activity of Pterostilbene or Crude Extract from Non-Fermented Grape Pomace Entrapped in Biopolymeric Nanoparticles
Authors: Simonetti Giovanna , Palocci Cleofe , Valletta Alessio , Kolesova Olga , Chronopoulou Laura , Donati Livia , Di Nitto Antonio , Brasili Elisa , Tomai Pierpaolo , Gentili Alessandra , Pasqua Gabriella
Published: May 2019

Polymeric nanoparticle-based carriers are promising agents to deliver drugs to cells. Vitis vinifera phenolic compounds are known for their antifungal activity against Candida albicans. The aim of the present study was to investigate the antifungal activity of pterostilbene or crude extracts from non-fermented grape pomace, entrapped in poly(lactic-co-glycolic) acid nanoparticles (NPs), with diameters of 50 and 150 nm, on Candida biofilm. The fluorescent probe coumarin 6 was used to study the uptake of poly(lactic-co-glycolic)acid (PLGA) NPs in planktonic cells and biofilm. The green fluorescent signal of coumarin 6 was observed in Candida biofilm after 24 and 48 hours. Both pterostilbene and crude pomace extract entrapped in NPs exerted a significantly higher anti-biofilm activity compared to their free forms. The entrapment efficiency of both pterostilbene and crude pomace extract in PLGA NPs was ~90%. At 16 µg/mL, pterostilbene loaded in PLGA NPs reduced biofilm formation of 63% and reduced mature biofilm of 50%. Moreover, at 50 µg/mL, the pomace extract loaded in NPs reduced mature biofilm of 37%. These results strongly suggest that PLGA NPs are promising nanodevices for the delivery of antifungal drugs as the crude grape pomace extract, a by-product of white wine making.
Development of the Inhibitors That Target the PD-1/PD-L1 Interaction—A Brief Look at Progress on Small Molecules, Peptides and Macrocycles
Authors: Guzik Katarzyna , Tomala Marcin , Muszak Damian , Konieczny Magdalena , Hec Aleksandra , Błaszkiewicz Urszula , Pustuła Marcin , Butera Roberto , Dömling Alexander , Holak Tad A.
Published: May 2019

Cancer immunotherapy based on antibodies targeting the immune checkpoint PD-1/PD-L1 pathway has seen unprecedented clinical responses and constitutes the new paradigm in cancer therapy. The antibody-based immunotherapies have several limitations such as high production cost of the antibodies or their long half-life. Small-molecule inhibitors of the PD-1/PD-L1 interaction have been highly anticipated as a promising alternative or complementary therapeutic to the monoclonal antibodies (mAbs). Currently, the field of developing anti-PD-1/PD-L1 small-molecule inhibitors is intensively explored. In this paper, we review anti-PD-1/PD-L1 small-molecule and peptide-based inhibitors and discuss recent structural and preclinical/clinical aspects of their development. Discovery of the therapeutics based on small-molecule inhibitors of the PD-1/PD-L1 interaction represents a promising but challenging perspective in cancer treatment.
Technetium Encapsulation by A Nanoporous Complex Oxide 12CaO•7Al2O3 (C12A7)
Authors: Kuganathan Navaratnarajah , Chroneos Alexander
Published: May 2019

Technetium (99Tc) is an important long-lived radionuclide released from various activities including nuclear waste processing, nuclear accidents and atmospheric nuclear weapon testing. The removal of 99Tc from the environment is a challenging task, and chemical capture by stable ceramic host systems is an efficient strategy to minimise the hazard. Here we use density functional theory with dispersion correction (DFT+D) to examine the capability of the porous inorganic framework material C12A7 that can be used as a filter material in different places such as industries and nuclear power stations to encapsulate Tc in the form of atoms and dimers. The present study shows that both the stoichiometric and electride forms of C12A7 strongly encapsulate a single Tc atom. The electride form exhibits a significant enhancement in the encapsulation. Although the second Tc encapsulation is also energetically favourable in both forms, the two Tc atoms prefer to aggregate, forming a dimer.
Study on the Physico-Chemical Properties of the Si Nanowires Surface
Authors: Puglisi Rosaria A. , Bongiorno Corrado , Borgh Giovanni , Fazio Enza , Garozzo Cristina , Mannino Giovanni , Neri Fortunato , Pellegrino Giovanna , Scalese Silvia , La Magna Antonino
Published: May 2019

Silicon nanowires (Si-NWs) have been extensively studied for their numerous applications in nano-electronics. The most common method for their synthesis is the vapor–liquid–solid growth, using gold as catalyst. After the growth, the metal remains on the Si-NW tip, representing an important issue, because Au creates deep traps in the Si band gap that deteriorate the device performance. The methods proposed so far to remove Au offer low efficiency, strongly oxidize the Si-NW sidewalls, or produce structural damage. A physical and chemical characterization of the as-grown Si-NWs is presented. A thin shell covering the Au tip and acting as a barrier is found. The chemical composition of this layer is investigated through high resolution transmission electron microscopy (TEM) coupled with chemical analysis; its formation mechanism is discussed in terms of atomic interdiffusion phenomena, driven by the heating/cooling processes taking place inside the eutectic-Si-NW system. Based on the knowledge acquired, a new efficient etching procedure is developed. The characterization after the chemical etching is also performed to monitor the removal process and the Si-NWs morphological characteristics, demonstrating the efficiency of the proposed method and the absence of modifications in the nanostructure.
Vitamin D Status and Components of Metabolic Syndrome in Older Subjects from Northern Finland (Latitude 65°North)
Authors: Mutt Shivaprakash Jagalur , Jokelainen Jari , Sebert Sylvain , Auvinen Juha , Järvelin Marjo-Riitta , Keinänen-Kiukaanniemi Sirkka , Herzig Karl-Heinz
Published: May 2019

Introduction: Vitamin D deficiency has been linked to the increased risk of several chronic diseases, especially in people living in the Northern Latitudes. The aim of this study was to assess the vitamin D status in older subjects born in 1945 in Northern Finland (latitude 65°North), and to examine its associations to components of metabolic syndrome (MetS). Methods: In this cross-sectional study, we invited 904 subjects born in 1945 from the Oulu region (Oulu45 cohort), out of an original cohort of 1332 subjects. In the cohort, plasma 25 hydroxyvitamin D (25OHD) levels were determined by an enzyme immunoassay of 263 men and 373 women, with a mean age baseline of 69±0.5 years old. We assessed the participants’ usage of vitamin D supplements, as well as their lifestyle factors, using a questionnaire. Results: Nearly 80% of the subjects had low vitamin D levels [either vitamin D deficient (<50 nmol/L) or insufficient (50 – 75 nmol/L)], and only 20% of the participants had sufficient vitamin D levels (>75 nmol/L) (based on the American Endocrine Society guidelines). The low vitamin D status was associated with a high prevalence of MetS; a significantly higher number of subjects with MetS (41%) had low vitamin D levels in comparison to the non-MetS subjects (38%) (p ≤ 0.05). The subjects under vitamin D supplementation had a significantly lower incidence of MetS (42.6% vs 57.4%) and its components in comparison to the non-supplemented subjects (p ≤ 0.05). Conclusions: Low vitamin D levels are a risk factor for MetS amongst other lifestyle factors, such as dietary habits and physical inactivity, among older subjects in the Northern Latitudes (65°North). Optimal supplementation of vitamin D, along with rich dietary sources of vitamin D, are highly recommended for older subjects as a means to positively affect, e.g., hypertension, insulin resistance, and obesity, as components of the MetS.