bluuebunny/crossref_metadata_2025 huggingface dataset:
ОЦЕНКА СОДЕРЖАНИЯ БИОЛОГИЧЕСКИ-АКТИВНЫХ ВЕЩЕСТВ В СВЕЖЕМ И ВЫСУШЕННОМ СЫРЬЕ БАЗИЛИКА КАМФОРНОГО (OCIMUM BASILICUM L.)
Authors: Н.В. Нестерова , К.И. Кравчук , В.Ю. Ермакова , Н.В. Бирюкова , Д.А. Доброхотов
Published: November 2024

В данной работе авторами было проведено качественное и количественное определение ряда известных групп билогически-активных веществ, таких как эфирные масла, полифенолы и антоцианы. Качественный анализ проводился характерными качественными реакциями и методом тонкослойной хроматографии. Количественная оценка исследуемых групп, проводилась известными фармакопейными методами (эфирные масла, антоцианы) и методом Фолина-Чокальтеу, широко применяемом в пищевой промышленности (полифенолы). Максимальный выход веществ характерен для свежего сырья базилика Перечного, в котором содержание эфирного масла составило 0,82%, полифенольных соединений - 6,42%, антоцианов - 0,560%

In this article the authors conducted a qualitative and quantitative determination of a number of known groups of bilogically active substances, such as essential oils, polyphenols and anthocyanins. Qualitative analysis was performed using characteristic qualitative reactions and thin-layer chromatography. Quantitative evaluation of the groups studied was carried out using well-known Pharmacopoeia methods (essential oils, anthocyanins) and the Follin – Chicalteu method, which is widely used in the food industry (polyphenols). The maximum yield of substances is typical for fresh raw materials of Pepper Basil, in which the content of essential oil was 0.82%, polyphenolic compounds – 6.42%, anthocyanins – 0.560%.
ТРЕХМЕРНАЯ АДДИТИВНАЯ ПЕЧАТЬ В ТЕХНОЛОГИИ ЛЕКАРСТВЕННЫХ ФОРМ
Authors: К.В. Алексеев , Е.В. Блынская , С.В. Тишков , А.А. Иванов , В.К. Алексеев
Published: November 2024

Аддитивные технологии (трехмерная печать) - сегодня наиболее развивающееся направление в различных сферах и отраслях. В фармацевтической отрасли этот вид производства тесно связан с концепцией персонифицированной медицины, где на основании личных данных пациента создается лекарственная форма с индивидуальными характеристиками. В обзоре представлен ряд технологий трехмерной печати с классификацией по физическому принципу работы различных видов 3D-принтеров. Описаны принцип действия, характеристики, преимущества и недостатки таких видов 3D-печати, как экструзионная печать, порошковая печать (TheriForm) и стереолитография. Продемонстрированы особенности применения трехмерной печати в таких лекарственных формах, как имплантаты, таблетки и трансдермальные системы доставки (пластыри с микроиглами). Сделан вывод о приемлемости трехмерной печати в фармацевтической технологии, показаны перспективы развития, необходимые условия для формирования нормативной базы и внедрения принципов аддитивного производства лекарственных форм в повседневную практику.

Additive technologies (three-dimensional printing) are currently the most developing area in various fields and industries. In pharmaceutical technology, this type of production is closely related to the concept of personalized medicine, where a dosage form with individual characteristics is created on the basis of the patients personal data. This literature review presents various 3D printing technologies with physical classification of different types of 3D printers. The principle of operation, characteristics, advantages and disadvantages of such types of 3D printing as extrusion printing, powder printing (TheriForm) and stereolithography are described. Demonstrated features of the use of three-dimensional printing in such dosage forms as: implants, tablets and transdermal delivery systems (patches with microneedles). The conclusion is made about the acceptability of three-dimensional printing to pharmaceutical technology, the development prospects and the necessary conditions for the formation of a regulatory framework and the introduction of the principles of additive production of dosage forms in everyday practice.
ИССЛЕДОВАНИЕ И РАЗРАБОТКА ГЕПАТОПРОТЕКТОРНОГО СРЕДСТВА
Authors: Е.В. Ферубко
Published: November 2024

Разработано многокомпонентное растительное средство под условным названием «Пентафит». В результате проведенных экспериментов установлено, что его курсовое введение per os в дозе 300 мг/кг нелинейным крысам с экспериментальными повреждениями печени оказывает антигепатотоксическое, гепатопротективное и мембраностабилизирующее действие.

A multicomponent plant agent under the conditional name "Pentafite" has been developed. As a result of the experiments carried out, it was found that its course administration per os at a dose of 300 mg/kg to nonlinear rats with experimental liver injuries has antihepatotoxic, hepatoprotective and membrane stabilizing effect.
РОССИЙСКИЕ ИСПЫТАТЕЛЬНЫЕ ЦЕНТРЫ: АСПЕКТЫ РАЗРАБОТКИ СИСТЕМ МЕНЕДЖМЕНТА КАЧЕСТВА ДЛЯ ВНЕДРЕНИЯ ПРИНЦИПОВ НАДЛЕЖАЩЕЙ ЛАБОРАТОРНОЙ ПРАКТИКИ
Authors: А.А. Таубэ , А.А. Шарафиева , Л.В. Шигарова , Е.В. Флисюк , А.В. Москвин
Published: November 2024

На основании анализа документов предложены 11 практических шагов по внедрению в деятельность испытательных центров, проводящих неклинические исследования лекарственных средств в соответствии с требованиями ГОСТ Р ИСО 9001-2015. Даны рекомендации для руководства и ответственных за внедрение в лаборатории стандартов ИСО. Внедрение системы менеджмента качества в соответствии со стандартами ISO серии 9000 (ГОСТ Р ИСО 9000-2015) является первым этапом подготовки испытательного центра к внедрению требований надлежащей лабораторной практики. Российские лаборатории, проводящие неклинические испытания на этапе разработки лекарственных средств, могут достичь значительных успехов, внедряя требования международного стандарта ISO 9001 в свою деятельность. На основе стандартов ИСО серии 9000 сформированы основные этапы по созданию системы менеджмента качества (СМК) в лаборатории, проводящей доклинические исследования.

Based on the analysis of the documents, 11 practical steps were proposed to introduce the requirements of GOST R ISO 9001-2015 into the activities of testing centers conducting non-clinical trials of drugs. Recommendations are given for the management and those responsible for the implementation of ISO standards in the laboratory. Based on the analysis of the requirements of international standards ISO 9001:2015 and GLP, it can be concluded that the decision to implement a quality management system in accordance with the ISO 9001 series (GOST R ISO 9001-2015) as the first stage of certification of a testing center for compliance with the requirements of an appropriate laboratory practice. Russian laboratories conducting non-clinical trials at the stage of drug development can achieve significant success by implementing the requirements of the international standard ISO 9001 in their activities. Based on ISO 9001 standards, steps are proposed to create a Quality Management System in an organization conducting preclinical research: management commitment and appointment of a quality representative, training of employees in ISO 9001, initial state analysis and planning, development of documents at appropriate levels, monitoring of implementation processes and audit.
ОСОБЕННОСТИ ФАРМАЦЕВТИЧЕСКОЙ РАЗРАБОТКИ ТАБЛЕТОК НА ОСНОВЕ СУХИХ ЭКСТРАКТОВ
Authors: А.В. Фотеева , М.П. Чугунова , Н.А. Прозорова , П.Н. Вшивков
Published: November 2024

Определение критических параметров технологического процесса является одним из важных аспектов фармацевтической разработки лекарственных препаратов стабильно высокого качества. Цель данной работы - выявление факторов, потенциально способных оказать влияние на качество и стабильность таблетированного лекарственного препарата, содержащего сухой экстракт алтея, - «Мукалтин, таблетки 50 мг». Для определения параметров, являющихся критическими при производстве таблеток мукалтина, было проведено изучение влияния ряда факторов на стабильность препарата в процессе хранения: влажность исходных компонентов; остаточная влажность готовой таблетки; физико-химические свойства вспомогательного компонента (изомерия винной кислоты); материал первичной упаковки. В ходе проведенного исследования установлено, что из изученных факторов к критическим параметрам процесса производства таблеток мукалтина относятся: влажность полупродуктов и готового продукта и материал упаковки.

The determination of critical process parameters is one of the most important development studies of the drug products which quality is consistently high. The purpose of this work is to identify the factors that can potentially affect the quality and stability of the drug product "Mukaltin, tablets 50 mg", containing althea dry extract. To determine the critical parameters of the manufacturing process of mucaltin tablets there were carried out some stability studies. We've studied the influence of different factors on the stability of this drug product during its storage. They are the humidity of the starting materials, the residual humidity of the finished product, physical and chemical properties of the excipient (isomerism of tartaric acid) and primary packaging material. During these studies it was revealed that such factors as the humidity of the intermediates and of the finished product and also the packaging material should be included to the critical process parameters.
ДОКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ БЕЗОПАСНОСТИ ЭКСТРАКТА СУХОГО ИЗ ПОДЗЕМНОЙ ЧАСТИ RHAPONTICUM UNIFLORUM
Authors: Я.Г. Разуваева , А.А. Торопова , Е.А. Убеева , В.Г. Банзаракшеев , В.В. Аюшева
Published: November 2024

В экспериментах на белых крысах линии Wistar исследовали хроническую токсичность и возможное местнораздражающее и мутагенное действие экстракта сухого из корневищ с корнями Rhaponticum uniflorum L. DC. Влияние экстракта сухого R. uniflorum на морфофункциональное состояние внутренних органов оценивали при его трехмесячном введении (per os) в дозах 100 и 500 мг/кг. Возможное местонораздражающее и мутагенное действие исследуемого средства определяли при его однократном введении в дозах 100 и 100 мг/кг. Установлено, что длительное введение экстракта сухого R. uniflorum не оказывает отрицательного влияния на морфофункциональное состояние центральной нервной, сердечно-сосудистой и мочевыделительной систем, органов желудочно-кишечного тракта, состояние обмена веществ, показатели периферической крови и системы гемостаза лабораторных животных. Исследуемое средство не вызывает местнораздражающего и мутагенного действия.

The purpose of this work is to determine chronic toxicity, as well as the possible local irritating and mutagenic effect of Rhaponticum uniflorum L. DC. root extract. The studies were performed on white Wistar rats. The effect of R. uniflorum extract on the morphofunctional state of internal organs was assessed after its three-month administration (per os) at doses of 100 and 500 mg/kg. The possible locally irritating and mutagenic effect of the investigational agent was determined with its single administration at doses of 100 and 1000 mg/kg. It was found that long-term administration of R. uniflorum extract does not have a negative effect on the morphofunctional state of the central nervous, cardiovascular and urinary systems, organs of the gastrointestinal tract, the state of metabolism, indicators of peripheral blood and the hemostasis system of laboratory animals. A single administration of the test agent in doses of 100 and 1000 mg/kg does not have a local irritating effect on the mucous membrane of the digestive tract and does not exhibit a mutagenic effect.
ПОДХОДЫ К СТАНДАРТИЗАЦИИ ТРАВЫ ТОПИНАМБУРА
Authors: О.Л. Сайбель , Е.А. Коняева , А.И. Радимич , Т.Д. Даргаева
Published: November 2024

Приведены результаты изучения нового вида лекарственного растительного сырья – топинамбура травы, предложенной в качестве сырья для производства лекарственных средств. Установлены критерии подлинности (морфологические и анатомо-диагностические признаки, тонкослойная хроматография) и показатели качества (номенклатура числовых показателей) данного вида сырья. Разработана методика количественного определения содержания действующих веществ. Предложенные критерии качества включены в проект фармакопейной статьи.

The results of the study of a new type of medicinal plant raw material - Jerusalem artichoke grass, proposed as a raw material for the production of medicines. The criteria of authenticity (morphological and anatomical diagnostic signs, thin-layer chromatography) and quality (nomenclature of numerical indicators) of this type of raw materials are established. A method of quantitative determination of the content of active substances has been developed. The proposed quality criteria are included in the draft pharmacopoeial article.
ТЕХНОЛОГИЧЕСКИЕ ПОДХОДЫ СОЗДАНИЯ ТВЕРДЫХ ЛЕКАРСТВЕННЫХ ФОРМ С СУБСТАНЦИЯМИ РАСТИТЕЛЬНОГО ПРОИСХОЖДЕНИЯ
Authors: Т.В. Качалина , Н.А. Малышева , О.А. Семкина
Published: November 2024

В работе представлены технологические аспекты разработки твердых лекарственных форм с субстанциями растительного происхождения с учетом их физико-химических свойств. Показана закономерность выбора лекарственной формы, вспомогательных веществ и параметров технологического процесса при получении таблеток и капсул на основе сухих экстрактов на всех этапах их разработки. Цель исследования - определение технологических подходов создания таблеток и капсул с сухими экстрактами растительного происхождения. Материалы: сухие экстракты растительного происхождения винограда культурного листьев красных, зюзника европейского травы, лапчатки белой корневищ и корней, сабельника болотного корневищ с корнями. Методы исследования позволили определить физико-химические и технологические характеристики субстанций, таблеточных композиций и капсульных масс на их основе. Изучение технологических параметров и физико-химических свойств субстанций растительного происхождения позволило осуществить рациональный выбор лекарственной формы (таблеток и капсул), а также вспомогательных веществ и их соотношения, разработать технологию получения лекарственного препарата.

The paper presents the technological and physical-chemical aspects of the development of solid dosage forms of phytopreparations, based on the characteristics (analysis results) substances of plant origin. The regularity of the choice of excipients, the need to determine their characteristics and parameters of the technological process when obtaining tablets and capsules based on dry extracts at all stages of their development is shown.
ПРИМЕНЕНИЕ УРАВНЕНИЙ ХЕККЕЛЯ И КАВАКИТЫ В ТЕХНОЛОГИИ ТАБЛЕТОК ГСБ-106
Authors: В.В. Буева , Е.В. Блынская , К.В. Алексеев , С.В. Тишков , С.В. Минаев
Published: November 2024

Проведены исследования механизмов, преобладающих в процессе прессования, с применением уравнений Хеккеля и Кавакиты, в результате которого описан процесс прессования таблеточной смеси и получены значения давлений: оптимального давления прессования и давления, необходимого для уменьшения материала в объеме на 50%.

Studies of compacting mechanisms were undertaken using the Heckel and Kawakita equations, which describes the process of tablet mass compacting. As a result the yield pressure and the pressure required to reduce the powder bed by 50% were obtained.
НОВЫЕ ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СУХОГО ЭКСТРАКТА КРАСНЫХ ЛИСТЬЕВ ВИНОГРАДА КУЛЬТУРНОГО (VITIS VINIFERA L.)
Authors: С.В. Лемясева , Л.В. Крепкова , А.Н. Бабенко , М.В. Боровкова , О.С. Кузина
Published: November 2024

В статье представлены результаты экспериментального изучения гиполипидемической активности сухого экстракта из красных листьев винограда культурного (Vitis vinifera L.). Показано, что исследуемый экстракт в дозе 500 мг/кг при введении в желудок нормолипидным крысам и с экспериментально воспроизведенной твиновой и алиментарной гиперлипидемией снижал содержание липидов и глюкозы в сыворотке крови подопытных животных. Полученные результаты позволяют рекомендовать его в составе комплексной терапии метаболического синдрома.

The results of experimental study of hypolipidemic activity of dry extract from red leaves of cultivated grapes (Vitis vinifera L.) are presented in the article. It was shown that the studied extract at a dose of 500 mg/kg when injected into the stomach of normolipid rats and with experimentally reproduced Twin and alimentary hyperlipidemia, reduced the lipid and glucose content in the blood serum of experimental animals. The obtained results allow to recommend it as a part of complex therapy of metabolic syndrome.
ПЕРСПЕКТИВЫ ПОЛУЧЕНИЯ И ИССЛЕДОВАНИЯ КЛЕТОЧНЫХ КУЛЬТУР ВИДОВ РОДА АРАЛИЯ(ARALIA SSP.)
Authors: Д.А. Некрасова , М.Н. Повыдыш , Н.С. Пивоварова , М.Ю. Гончаров
Published: November 2024

В данной статье обобщена информация о характеристике, охранном статусе, способах введения в культуру in vitro представителей рода Aralia L., описаны накапливаемые культурами клеток вторичные метаболиты

This article summarizes information about the characteristics, conservation status, methods of introducing into culture in vitro plants of the genus Aralia L., describes the secondary metabolites accumulated by cell cultures.
E-COMMERCE EN COMPRA DE PRODUCTOS ANALÓGICOS DE ESTUDIANTES
Authors: Cacya Huamani Emmi Judit , Calcino Quisini Kevin , Condori Ari Maritza , Córdova Salón Fiorella Nicol , Hinojosa Ccama Jonathan Romario , Mamani Torres Karla Yahaira , Merma Zuñiga Axel Adolfo
Published: November 2024

Objetivo. Demostrar el nivel de satisfacción que tuvieron los estudiantes de Administración de la UNSA después de incursionar en el E-commerce y ver los cambios del proceso logístico durante la pandemia, 2020-2021. Materiales y métodos. El estudio fue cuantitativo de tipo explicativo y descriptivo, de diseño no experimental. La población y muestra estuvo conformada por 305 personas anteriormente seleccionadas por conveniencia, para la recolección de datos se usaron bases de datos académicas y la encuesta. Para la búsqueda de información se usaron fuentes primarias y secundarias. Resultados y conclusiones. El E- commerce se constituyó como el canal de venta más importante durante la pandemia por la fácil accesibilidad para realizar el comercio es por ello que en base a este tipo de comercio electrónico el proceso ogístico tuvo que realizar cambios e implementar nuevas estrategias con el fin de que este se adecue a la situación actual, además los estudiantes universitarios tienen una adaptabilidad a las nuevas tecnologías la cual contribuyó a que este tipo de comercio se dé satisfactoriamente.
FACTORES ESTRATÉGICOS EN TIEMPO DE CRISIS PARA GENERAR CRECIMIENTO EN LAS EMPRESAS FAST FOOD, BAJO EL MODELO DE NEGOCIOS DE FRANQUICIA
Authors: Granados García Jafel , Arce Larrea Glenn Roberto
Published: November 2024

Objetivo: Identificar los factores estratégicos que generen crecimiento en empresas fast food en tiempo de crisis. Métodos: A través de un estudio de alcance correlacional. Se identifica y analiza las características del consumidor, los factores que contribuyan al crecimiento de empresas fast food bajo el modelo de negocio: franquicia. El presente estudió se realizó en el mes de diciembre del 2020, en donde se encuestaron a 195 personas entre hombres y mujeres de 20 a 39 años que viven en Arequipa, que buscan rapidez en el servicio y flexibilidad en los horarios debido a su estilo de vida ajustado y dinámico. Considerando dimensiones del modelo de Servqual y coeficiente de Spearman para la determinación de la relación entre los factores estratégicos y el creciente de las empresas. Resultados: Los consumidores encuestados en su mayoría consumen en las empresas como: KFC (34.5%), Pizza Hut (25.4%) y Mc Donald’s (17.8%). El coeficiente de Spearman fue de 0.49 (Confianza – Aseguramiento), demostrando que existe una relación positiva entre las variables. Conclusiones: A través de la investigación se ha determinado que los factores que contribuirán al crecimiento de las empresas son la confianza, empatía y sensibilidad, el comportamiento del consumidor se ha visto afectado por la coyuntura actual, aun así, se ha ido adaptando poco a poco, pero aun es un riesgo presente.
APROXIMACIÓN PROTEÓMICA DE FOSFOLIPASAS A2 (PLA2 Y HOMOLOGA K49) A PARTIR DEL VENENO DE BOTHROPS BARNETTI Y SU BIOPROSPECCIÓN EN ESTUDIOS PROINFLAMATORIOS POR ANÁLISIS BIOINFORMÁTICO. AREQUIPA, 2019
Authors: León Puma Nicolás Hipólito , León Ramos Yubica Allisón
Published: November 2024

Se ha logrado purificar y caracterizar bioquímicamente una fosfolipasa A2 y una homóloga K49 a partir del veneno total de Bothrops barnetti de procedencia peruana.
 
En la purificación de ambas proteínas la fosfolipasa A2 y la fosfolipasa A2 homóloga K49, se ha empleado un paso cromatográfico a través de una cromatografía convencional de interacción hidrofóbica, donde se obtuvo nueve fracciones: denominadas del 1 al 9 respectivamente. La fracción 5 fue caracterizada bioquímicamente como una fosfolipasa A2 al medir su actividad enzimática frente a un sustrato cromogénico altamente específico como es el 4-nitro-3 (octanoiloxi) acido benzoico a pH de 7,9. De otro lado se caracterizó estructuralmente una fosfolipasa A₂ homóloga K49 desprovista completamente de actividad catalítica.
 
La electroforesis bidimensional (2D), reveló el carácter de 5 fracciones denominadas como P101, P102, P103, P104 y P105 respectivamente por poseer una masa aproximada de 14 kDa y un pI en alrededor de 7.6 a 8.5 lo que evidenciaría la presencia de fosfolipasas A2 y/o homólogas K49, a partir del veneno total desde una perspectiva de aproximación proteómica.
 
La secuencia de aminoácidos fue determinada vía espectrometría de masas ESI-MS/MS y se caracterizaron dos toxinas una fosfolipasa A2 y una fosfolipasa A₂ homóloga K49. Los estudios de homología secuencial utilizando las bases de datos desde su identificador con el programa MASCOT y la base de datos del Swiss prot, nos permitió confirmar la deducción de la cadena polipeptídica tratándose de estas 2 proteínas estudiadas.
 
Desde la perspectiva farmacológica se exploraron las actividades edematogénicas en el experimento edema de pata, en el que quedó claramente evidenciado su efecto proinflamatorio de ambas toxinas, donde la actividad catalítica podría ser o no importante. Hecho que fue confirmado con el dosaje
de los niveles de IL-6 los cuales mostraron ser tiempo-dependientes como un efecto local.
DECORONACIÓN- UN PROCEDIMIENTO PARA MANTENER EL REBORDE ALVEOLAR EN DIENTES CON REABSORCIONES POR SUSTITUCIÓN (ANQUILOSIS).
Authors: Monteiro Bramante Clovis , Gallegos Misad Pedro Pablo , Silva Bramante Alexandre , Khouri Diep Eduardo , Gallegos Vargas Herbert Mario , Quiroz Huerta Carlos Alberto
Published: November 2024

Decoronación es un procedimiento en el cual la corona del diente comprometido es removida, manteniendo la raíz. Dientes con reabsorción por sustitución pueden provocar, además de la reabsorción de la raíz, la pérdida del hueso alveolar, dificultando después la sustitución protética del diente.
Este procedimiento tiene como objetivo mantener la altura y ancho del hueso alveolar.
 
Este caso clínico describe la técnica de la Decoronación y la presentación de un caso clínico.
 
El Control clínico y radiográfico después de 1 año, muestra la mantención del nivel del reborde alveolar.
DIABETES MELLITUS E INFECCIONES PERIIMPLANTARIAS
Authors: Monzón Javier , Caramello Carlos , Acuña Miguel , Benítez María , Cáceres Naomi , Escalante Otárola Wilfredo G.
Published: November 2024

Son numerosos los estudios que indican que la diabetes afecta negativamente a la salud periodontal, particularmente como consecuencia de su naturaleza inflamatoria. Siguiendo éste razonamiento, es probable entonces que esa alteración metabólica ejerza influencia también en las patologías periimplantarias. Ésta revisión pretende aportar, desde las evidencias científicas publicadas en los últimos años, la potencial asociación de la diabetes mellitus con la etiología de la periimplantitis. Para ésto se realizó una búsqueda bibliográfica a través de PubMed y Embase (electronic databases). Llegando a la conclusión que, a pesar de no existir evidencias definitivas y absolutas de aquella asociación, debe considerarse la alta posibilidad que ésta enfermedad represente al menos un serio factor de riesgo para la periimplantitis aconsejando, al paciente diabético portador de implantes, mantener un permanente control sobre su nivel de glucosa.
DIAGNÓSTICO TEMPRANO DE AMBLIOPÍA
Authors: Noel Córdova Edgard
Published: November 2024

Propósito
Discutir el uso del examen visual con y sin instrumentos para detectar ambliopía y sus factores de riesgo, y resumir la importancia del examen visual entre los 4-5 años.
 
Método
La experiencia del autor fue complementada por una revisión e interpretación de la literatura médica pertinente.
 
Resultados
 La ambliopía es una enfermedad asintomática y el tratamiento es mucho más eficaz si se lleva a cabo a una edad más temprana. El diagnóstico de ambliopía tiene mejores resultados cuando se realiza un examen visual completo entre los 3-5 años que el examen visual realizado con instrumentos en niños menores de 3 años; La US Preventative Services Task Force (USPSTF) recomienda el examen visual al menos una vez en niños de 3-5 años para detectar ambliopía o sus factores de riesgo. La detección temprana de ambliopía permite que un tratamiento más efectivo pueda ser iniciado.
 
Conclusiones
La ambliopía es una causa reversible de pérdida visual en los niños. Si bien los programas de examen visual con instrumentos han sido ampliamente estudiados en niños menores de 3 años; se recomienda el examen visual en niños entre los 3-5 años.
CRECIMIENTO DEL RABANITO CHAMPION (Raphanus sativus L.), EN RESPUESTA A LA BIOFERTILIZACIÓN CON RESIDUOS HIDROBIOLÓGICOS.
Authors: Begazo Abril Noelia
Published: November 2024

Los efectos dañinos de los fertilizantes químicos sobre el medio ambiente están comprobados, su uso excesivo ocasiona graves problemas de contaminación en suelos y aguas subterráneas. Los biofertilizantes representan una opción viable y sostenible para la agricultura; la reutilización de residuos hidrobiológicos, constituye una excelente alternativa. Tras un proceso de experimentación de 90 días, se evaluó el crecimiento del rabanito champion, en respuesta a la biofertilización con residuos hidrobiológicos, obtenidos de residuos de algas marinas y pescados. Se realizaron siete tratamientos en macetas: biofertilizante casero, biofertilizante con residuos hidrobiológicos (6 tipos de mezclas), diluidas en cuatro dosis: 0.5:20, l:20, 1.5:20 y 2:20 ml/L de agua y un testigo sin fertilizante (solo agua); todos los tratamientos se duplicaron. La combinación 60 % pescado – 40 % algas, con una dosis de 2:20 ml/L de agua, tuvo mejores resultados en cuanto a crecimiento, pues el pescado es alto en nitrógeno y fósforo, mientras que las algas marinas son ricas en potasio, demostrando ser una combinación estable para obtener un buen crecimiento. Las dosis altas en algas marinas no tuvieron efectos positivos por su alto contenido en boro. Los altos valores de conductividad eléctrica y concentración de Na, están asociados a una elevada salinidad. Los tratamientos solo pescado o solo algas no fueron eficientes. Se concluyo que los residuos de pescado y algas marinas, en proporción 60/40 son eficientes para ser utilizados como biofertilizante, con mejores resultados en comparación a otras fuentes orgánicas.
Inclusive Android-Based Solution: E-Book Reader Application with Text-To-Speech for Empowering People with Disabilities
Authors: Muhammad Fathan Ramadhan  , Suhirman
Published: November 2024

One of the growing innovations is an e-book reader application equipped with a text-to-speech (TTS) feature. This research aims to design and develop an e-book reader application that can convert text into speech. The application is designed using the Agile software development method, which allows for iterations and continuous improvements based on user feedback. The main features of this application include the ability to adjust the speed and type of voice, as well as support for various e-book formats such as ePub, PDF, and TXT. The TTS implementation leverages available APIs, enabling high-quality and natural text-to-speech conversion. The evaluation of this application shows that users feel supported by the TTS feature, and the method used is quantitative. Testing results and feedback from early users indicate that this application not only improves accessibility but also provides a more flexible and comfortable reading experience. Therefore, this text-to-speech e-book reader application is expected to become an effective solution in supporting literacy and accessibility for all groups.
Design of an Android-based Letter Submission Application for Panjer Village
Authors: Akbar Surya Pamungkas
Published: November 2024

This study aims to show the existence of a problem that occurs in Kelurahan Panjer related to the submission of correspondence for villagers. The distance of the village head office makes access to the submission of letters hampered and even difficult to do. The methods used in this research include interviews with Panjer village residents, observation by looking directly at the field and using previous research as a comparison material. The purpose of this research is to speed up the process of submitting citizen letters and implementing the government's mandate on E-Government as a form of government responsibility to its citizens. The result of this research is a letter submission application with 6 types of letters that can be submitted. This research concludes that with this application, letter submission becomes faster because villagers do not need to come to the village office.
Sentiment Analysis on Social Media Instagram of Depression Issues Using Naïve Bayes Method
Authors: Voni Anggraeni Suwito Putri  , Vitianingsih Anik Vega , Rusdi Hamidan  , Anastasia Lidya Maukar  , Niken Titi Pratitis
Published: November 2024

The rapid expansion of the digital era has turned social media, especially Instagram, into a crucial source for examining public sentiment on mental health issues such as depression. Depression, a condition that adversely affects thoughts, behaviours, emotions, and overall mental well-being, is often less apparent than physical health problems, leading to delays in treatment. Low public awareness and societal stigma further aggravate these delays, making sufferers hesitant to seek professional help and more inclined to share their experiences online. This study aims to analyze public sentiment on Instagram concerning depression through the Naïve Bayes (NB) method. It involves developing an application that visualizes analysis reports via bar and pie charts, categorizing public comments on depression as neutral, positive, or negative. Data is sourced from Instagram using keywords related to depression and mental health, with lexicon-based methods for labelling and NB for sentiment classification. The findings show the effectiveness of this method, with the accuracy rate reaching 79%. The dataset consists of 1300 comments collected through web crawling. This evaluation displays the performance results of NB achieving an accuracy of 82.55%. The study aims to offer insights into public opinions on depression, provide datasets for future sentiment analysis research, and assess the NB method's effectiveness in managing complex sentiments on social media, ultimately aiming to improve public understanding and strategies for mental health intervention.
Mobile Application System For Point of Sales in Coffee Sales at Langit Coffee Space
Authors: Yusril Aziz
Published: November 2024

The coffee shop industry in Indonesia is experiencing rapid growth, leading to intense competition among businesses. Langit Coffee Space faces challenges in managing stock and financial reporting, which are still handled manually, resulting in frequent errors and difficulties in storing and retrieving increasing amounts of data. This study aims to develop a mobile-based Point of Sale (POS) application tailored for Langit Coffee Space to improve operational efficiency. Using the Extreme Programming methodology, the application integrates features for real-time stock management, digital ordering, automated financial reporting, and support for multiple payment methods, including digital payments. Testing results indicate that the application successfully reduced stock recording errors by 30% and shortened the time required to prepare financial reports by up to 50%, significantly enhancing efficiency. Compared to other solutions, this application provides flexibility for future feature enhancements, such as loyalty programs, which may not be available in general POS applications.
Checklist of gasteroid fungi from Lithuania
Authors: Iršėnaitė Reda , Urbonaitė Rūta
Published: November 2024

The article presents a list of the gasteroid fungi species found in Lithuania. A total of 67 species belonging to the 20 genera have been identified in Lithuania. The list includes the Latin names of the fungi in alphabetical order alongside their Lithuanian names. All names of the gasteroid fungi in Lithuania have been approved by the State Lithuanian Language Commission.
Checklist of agaricoid and boletoid fungi species from Lithuania
Authors: Kasparavičius Jonas
Published: November 2024

The checklist summarises the available data on agaricoid and boletoid fungi species found in Lithuania. The scientific and Lithuanian names of the fungi are presented in alphabetical order. All Lithuanian names of fungi have been approved by the State Commission of the Lithuanian Language. By 2024, a total of 1463 species of agaricoid fungi from 165 genera have been identified in Lithuania.
Efficacy of Rifaximin and Probiotics in the Treatment of Small Intestinal Bacterial Overgrowth When Used Concomitantly or Sequentially
Authors: Hammour Adnan , Abu-Hammour Mohamad-Noor , Al-Sheyyab Ahmad , Dajani Asad
Published: November 2024

Background: With the prevalence of small intestinal bacterial overgrowth (SIBO) on the rise, treatment has become of paramount importance for patients suffering from this disease. Antibiotics used to treat SIBO include rifaximin, ciprofloxacin, metronidazole, and neomycin. Probiotics reinforce the small intestine's internal microbiota and help cure many diseases.
 
Aim: In this study, we aimed to evaluate the efficacy of rifaximin together with a multi-strain probiotic in patients with SIBO. In a multi-center open-labeled prospective study, recruited patients were randomized into two groups treated with rifaximin as a base and probiotics that varied in the timing of initiation (concomitantly; group A or sequentially; group B) for treating the clinical manifestations of the disease. The primary endpoint evaluated the clinical response to treatment, and the secondary endpoint evaluated the eradication rates.
 
Results: Eradication rates revealed that 69.8% of the patients in group A and 74.8% of the patients in group B were successfully treated and returned with negative lactulose hydrogen breath test results. Clinical response rates were divided into partial and complete responders; partial responders were reported in 23.3% and 26.6% of patients in groups A and B, respectively, and complete responders were reported in 62.7% and 59.5% of patients in groups A and B, respectively. Overall, partial or complete responders' combined rate comprised 86% and 86.2% in groups A and B, respectively. There were no reported side effects by patients treated with rifaximin and the multi-strain probiotic for both protocols.
 
Conclusion: The addition of probiotics, both concomitantly or sequentially, to the treatment regimen acts synergistically with rifaximin to improve outcomes. According to our study, there were no statistical differences between the two regimens. In conclusion, the extension of probiotics in the sequential regimen provided a more prolonged clinical response rate.
A Retrospective Study of Glomerulonephritis Patterns Among Jordanian Children
Authors: Sheyyab Ahmed , Hamed Radi
Published: November 2024

Background and Aim: Glomerular diseases affecting pediatric patients differ from conditions encountered in adults. Additionally, the pattern of glomerular disease varies in different regions of the world. In the Mediterranean region, data on glomerular diseases in children patients remain sparse. Therefore, we conducted a study to assess glomerulonephritis disease patterns at our institute and assess for recent incidence trends.
 
Methods: A retrospective study conducted at a university affiliated tertiary hospital located in the capital city of Amman. We included native kidney biopsy reports of patients who fulfilled our age criterion of < 15 years old.
 
Results: Our study showed a total of 178 kidney biopsies, of which 71 patient fulfilled our inclusion criteria. The average age of studied patients was 7.6 ± 4.1 years. Our study had more males compared to females, 56% and 44%, respectively. In nephritic syndrome, IgA nephropathy was the most common cause (13%), which was followed by Post-Infectious glomerulonephritis (8%). In children with nephrotic syndrome, MCD was exceedingly more common in male children when compared to females, 14 versus 8 patients, respectively. While FSGS was more common among females compared to males, 5 versus 2 patients, respectively.
A Comprehensive Evaluation of the Preanalytical Phase in Laboratory Medicine, Nephrology, Emergency Specialties, Visceral Surgery, Pediatrics, Internal Medicine and Neonatology Hospital Departments: In-Depth Insights derived from an analysis of practices at a Medical University Centre in Morocco
Authors: Rahhab Oussama , Sebbar El houcine , Choukri Mohammed
Published: November 2024

Background and Aims: The precision of biological examination results hinges on meticulous preparatory measures before analysis, known as the pre-analytical phase. This phase contributes significantly to error rates (48-68%). Our study assessed the pre-analytical phase in seven hospital departments at Mohammed VI University Hospital. The objective was to address key causes of pre-analytical nonconformities.
 
Materials and Methods: During this investigation, we observed 331 samples from various departments: Central Laboratory, Nephrology, Internal Medicine, Visceral Surgery, Emergency Specialties, Paediatrics, and Neonatology. Our evaluation identified 4945 instances of pre-analytical nonconformities. These cases encompassed issues with the prescription sheet (501), patient preparation (848), equipment preparation (295), sampling process (1957), waste management (323), and sample transfer (422).
 
Results: Our analysis highlighted a multitude of pre-analytical nonconformities within the surveyed hospital departments. These discrepancies illuminated the critical areas where corrective and preventive measures were imperative to adhere to the standards set by the International Standard ISO15189 and to optimize patient care.
 
Conclusions: The findings from this study underscore the paramount importance of the pre-analytical phase in ensuring accurate biological examination results. By implementing a series of targeted actions in the concerned hospital departments, we addressed the identified nonconformities. These actions encompassed ongoing education, staff awareness and support, regular audits, provision of technical resources such as manuals and sample catalogues, as well as the utilization of appropriate equipment for sample collection and transportation. Continuous learning remains essential, encompassing proper sampling techniques, packaging and transportation requisites, as well as procedures for identifying and rectifying biological sample nonconformities
Acceptance of Cosmetic Surgery: Client Perspectives
Authors: Ibrahim Radhwan , Ibrahim Dunia
Published: November 2024

Background: In the past decade, there has been an increase in the number of cosmetic procedures performed globally. About one-third of individuals who undergo cosmetic procedures are under the age of 35 years. Several factors can influence acceptance of cosmetic surgery including media, religion, and individual factors among others.
 
Objective: The objective of this current study is to investigate the motivations behind individuals choosing to undergo cosmetic surgery.
 
Material and methods: This study was a cross-sectional single-center, conducted to assess the attitudes and acceptance of cosmetic surgery among attendees at Cosmetic and beauty centres in the city of Mosul, Iraq between September -November of 2022. All patients at the plastic surgery clinics were given a questionnaire that they were instructed to fill out in their own time. The likelihood of having cosmetic surgery scale, the Rosenberg self-esteem scale, the life happiness scale, and the physical attractiveness scale were used to measure the correlation between these variables and other factors. With a p-value of less than 0.05, the results might be considered reliable. Pearson's correlation coefficient was used for the investigation of correlations (r).
 
Results: The mean age was 31.47 years, the standard deviation was 2.8, the range of ages was 15-52 years, and the median age was 29.89 years. There was an insignificant weak positive connection between participants' self-esteem and their acceptance of cosmetic surgery (r=0.052)
 
Conclusion: Lower levels of self-esteem and life satisfaction, greater exposure to cosmetic surgery in the media (especially television), increased time spent in front of the TV, and religious affiliation were all found to be significant predictors of future use of cosmetic surgery in the current study.
The Incidence of Psychosis Among Parkinson's Disease Patients and Associated Factors: A Meta-Analysis
Authors: Alsharaeh Tala , Salahat Ahmed-Jordan , Alhajahjeh Abdulrahman , Khudirat Mohammad , Alashoor Ali , Shuriquie Leith , Alquabeh Batool , AlRyalat Saif Aldeen
Published: November 2024

Introduction: Parkinson's-induced psychosis is rather prevalent, and it has continuously been linked to poor outcomes. Therefore, detecting this presentation early on, can enhance the quality of life of Parkinson’s disease patients and is therefore a clinical and societal necessity. This systematic review and meta-analysis aimed to estimate the pooled incidence of induced psychosis or psychosis associated with neurodegeneration in Parkinson’s disease.
 
Materials and Methods: PubMed, Scopus, and Cochrane Library were searched to identify studies reporting the prevalence of psychosis in Parkinson’s disease patients. A random-effect meta-analysis was used to pool data from the included studies. The objectives, inclusion criteria, and methods of analysis for this review were specified in advance and documented in a priori protocol (PROSPERO reg. num. CRD42022318920).
 
Results: Twenty studies including 5,123 Parkinson’s disease patients which explored the incidence of presenting symptoms of psychosis in Parkinson’s disease patients were included in the final analysis. The meta-analysis showed that the incidence of psychosis among Parkinson’s disease patients was 35%. A subgroup analysis was performed which showed that disease duration could explain the statistical heterogeneity in this meta-analysis.
 
Conclusion: This systematic review and meta-analysis revealed that psychotic disorders are highly prevalent among Parkinson’s disease patients, indicating an urgent need for further studies to help develop better mechanisms of prevention, detection, and treatment of those disorders among Parkinson’s disease patients in an effort to improve their quality of life.
EXPLORING ELECTROMECHANICAL SYSTEMS IN THE DEVELOPMENT OF NEXT-GENERATION ELECTRIC POWERTRAINS
Authors: STOZHOK O. O.
Published: November 2024

In the rapidly evolving electric vehicle industry, the study of electromechanical systems in next-generation electric powertrains is of particular relevance. This is driven by the need to enhance energy efficiency, reduce costs, and improve the reliability of vehicles. The article examines the role of innovative materials, advanced design methods, and control algorithms in creating high-efficiency and reliable electric powertrains. Specifically, the impact of nanomaterials such as graphene and carbon nanotubes on reducing motor weight and increasing heat dissipation is analyzed, contributing to improved efficiency and extended driving range. The adoption of additive manufacturing (3D printing) and digital twins accelerates prototyping and component optimization in electric powertrains. Adaptive control algorithms ensure optimal system performance in real-time, enhancing overall efficiency and reliability. Research methods included the analysis of modern materials and technologies, prototyping using additive manufacturing, and the implementation of predictive and adaptive control algorithms. The results demonstrate significant improvements in the performance of electric powertrains due to the use of innovative materials and cutting-edge design technologies. Conclusions confirm that the application of advanced materials and adaptive control algorithms is critical for ensuring the sustainable development of the electric vehicle industry. Future research prospects focus on further refining materials and technologies to enhance scalability and reduce production costs, making electric powertrains more accessible and efficient.
УДОСКОНАЛЕННЯ ТЕХНОЛОГІЇ ЕЛЕКТРОІСКРОВОГО ЛЕГУВАННЯ ДЕТАЛЕЙ НАСОСІВ АТОМНИХ ЕЛЕКТРОСТАНЦІЙ
Authors: ТАРЕЛЬНИК Н. В.
Published: November 2024

В статті розглядається проблема зчеплення і залипання електроду-інструменту (ЕІ) (аноду) з поверхнею деталі, яку легують (катоду). Особливо це проявляється коли необхідно проводить електроіскрове легування (ЕІЛ) деталей з корозійностійких нержавіючих сталей, які переважною більшістю використовуються в насосах на атомних електростанціях (АЕС). При збільшенні енергії розряду (Wр), при легуванні на більш «грубих» режимах ЕІЛ проблема стає більш актуальною. З метою проведення порівняльних випробувань на установці електро- іскрового легування моделі «Елітрон 52А» проводили обробку 3-х партій зразків, розміром 15х15х8 мм зі сталі 12Х18Н10Т. В якості ЕІ використовували стержні Ø3 мм і L=30 мм з сталі 12Х18Н10Т і нікелю. В першій партії зразки нічим попередньо не оброблялись. В другій партії зразки попередньо обробляли графітовим ЕІ, а в третій – поверхню, що легують, натирали порошком з дисульфіду молібдену. В результаті проведення досліджень удосконалена технологія ЕІЛ корозійностійких сталей, що використовують для виготовлення деталей обладнання АЕС при який на поверхню, що легують, шляхом натирання (намазування) наносять порошок дисульфіду молібдену, що різко покращує процес легування за рахунок усунення зчеплення (прилипання) електродів. В цьому випадку при будь-яких значеннях енергії розряду при ЕІЛ зчеплення (прилипання) електродів аноду і катоду відсутнє. При порівнянні різних способів ЕІЛ сталі 12Х18Н10Т ЕІ зі сталі 12Х18Н10Т встановлено, що при ЕІЛ без попередньої обробки поверхні зразка, в порівнянні з попередньою обробкою поверхні графітом і дисульфідом молібдену, при однакових значеннях енергії розряду, продуктивність, відповідно в 35 і 44 раз менше, шорсткість в 1,7 і 2,0 раз більше, а суцільність в 1,3 і 1,5 раз менше. При порівнянні різних способів ЕІЛ сталі 12Х18Н10Т ЕІ з нікелю, встановлено, що при ЕІЛ без попередньої обробки поверхні зразка, в порівнянні з попередньою обробкою поверхні графітом і дисульфідом молібдену, при однакових значеннях енергії розряду, продуктивність, відповідно в 177 і 197 раз менше, шорсткість в 2,1 і 2,5 раз більше, а суцільність в 1,9 і 2,1 раз менше.