bluuebunny/crossref_metadata_2025 huggingface dataset:
Socioeconomic Status and Glycemic Control in Type 2 Diabetes; Race by Gender Differences
Authors: Assari Shervin , Moghani Lankarani Maryam , Piette John , Aikens James
Published: November 2017

Background: This study aimed to investigate differences in the association between socioeconomic status (SES) and glycemic control in type 2 diabetes mellitus (DM) across race by gender groups. Methods: Using a convenient sampling strategy, participants were 112 patients with type 2 DM who were prescribed insulin (ns = 38 Black women, 34 Black men, 14 White women, and 26 White men, respectively). Linear regression was used to test the associations between sociodemographic variables (race, gender, SES, governmental insurance) and Hemoglobin A1c (HbA1c) in the pooled sample and within subgroups defined by race and gender. Results: In the pooled sample, neither SES nor governmental insurance were associated with HbA1c. However, the race by gender interaction approached statistical significance (B = 0.34, 95% CI = −0.24–3.00, p =0.094), suggesting higher HbA1c in Black women, compared to other race by gender groups. In stratified models, SES (B = −0.33, 95% CI = −0.10–0.00, p = 0.050), and governmental insurance (B = 0.35, 95% CI = 0.05–2.42, p = 0.042) were associated with HbA1c for Black men, but not for any of the other race by gender subgroups. Conclusion: Socioeconomic factors may relate to health outcomes differently across race by gender subgroups. In particular, SES may be uniquely important for glycemic control of Black men. Due to lack of generalizability of the findings, additional research is needed.
Bibliometric Analysis of Global Remote Sensing Research during 2010–2015
Authors: Zhang Hongyue , Huang Mingrui , Qing Xiuling , Li Guoqing , Tian Chuanzhao
Published: November 2017

Bibliometric analysis based on the Science Citation Index Expanded published by Thomson Scientific was carried out to identify the research status and future trends of remote sensing (RS) during 2010–2015. The analysis revealed the institutional, national, spatio-temporal, and categorical patterns in remote sensing research both from the WP (whole publications) viewpoint and the HCP (highly-cited publications) viewpoint. Statistical analysis results showed that remote sensing research almost doubled during 2010–2015. Environmental sciences comprised the most attractive subject category among remote sensing research. The International Journal of Remote Sensing was the most productive journal, and Remote Sensing of Environment published the most HCP among the 31 distributed journals. The productive ranking of countries was led by the U.S. both from the WP viewpoint and the HCP viewpoint, and CAS (Chinese Academy of Sciences) was the most productive institute both from the WP viewpoint and the HCP viewpoint with lower CPP (average number of citations per paper). Keyword analysis illustrated that model and algorithm research were the key points in RS during 2010–2015. RS data including Moderate-Resolution Imaging Spectroradiometer (MODIS), Landsat, synthetic aperture radar (SAR), and LiDAR (light detection and ranging) were the most frequently adopted, but the data usage of UAVs (unmanned aerial vehicles) and small satellites will be promoted in the future. With the development of data acquisition abilities, big data issues will become the challenges and hotspots of RS research, and new algorithms will continue to emerge.
Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases
Authors: Bistrović Andrea , Harej Anja , Grbčić Petra , Sedić Mirela , Kraljević Pavelić Sandra , Cetina Mario , Raić-Malić Silvana
Published: November 2017

A series of mono-pyrrolo[2,3-d]pyrimidines 4a–4k, unsymmetrical bis-purine isosteres 5a–5e and symmetrical bis-pyrrolo[2,3-d]pyrimidines 6a and 6b connected via di(1,2,3-triazolyl)phenyl linker were synthesized by click chemistry. Whereas mono- 4g and bis-pseudopurine 5e showed selective inhibitory activities on cervical carcinoma (HeLa) cells, bis-pyrrolo[2,3-d]pyrimidine 6b exhibited potent and selective anti-proliferative effect in the nanomolar range on pancreatic carcinoma (CFPAC-1) cells. Among these, compound 6b induced a significant reduction in the expression level of CDK9 (cyclin-dependent kinase 9)/cyclin T1 in CFPAC-1 cells concomitant with attenuation of proliferative signaling mediated by c-Raf (rapidly accelerated fibrosarcoma) and p38 MAP (mitogen-activated protein) kinases. Our findings encourage further development of novel structurally related analog of 6b to obtain more selective anticancer agent for treating pancreatic cancer.
Inter-Species Host Gene Expression Differences in Response to Human and Avian Influenza A Virus Strains
Authors: Taye Biruhalem , Yeo Dawn , Lee Raphael , Tan Boon , Sugrue Richard , Maurer-Stroh Sebastian
Published: November 2017

Low pathogenic avian influenza (LPAI) viruses are a source of sporadic human infections and could also contribute to future pandemic outbreaks but little is known about inter-species differences in the host responses to these viruses. Here, we studied host gene expression signatures of cell lines from three species (human, chicken, and canine) in response to six different viruses (H1N1/WSN, H5N2/F59, H5N2/F118, H5N2/F189, H5N3 and H9N2). Comprehensive microarray probe set re-annotation and ortholog mapping of the host genes was necessary to allow comparison over extended functionally annotated gene sets and orthologous pathways. The annotations are made available to the community for commonly used microarray chips. We observe a strong tendency of the response being cell type- rather than virus-specific. In chicken cells, we found up-regulation of host factors inducing virus infectivity (e.g., oxysterol binding protein like 1A (OSBPL1A) and Rho GTPase activating protein 21 (ARHGAP21)) while reducing apoptosis (e.g., mitochondrial ribosomal protein S27 (MRPS27)) and increasing cell proliferation (e.g., COP9 signalosome subunit 2 (COPS2)). On the other hand, increased antiviral, pro-apoptotic and inflammatory signatures have been identified in human cells while cell cycle and metabolic pathways were down-regulated. This signature describes how low pathogenic avian influenza (LPAI) viruses are being tolerated and shed from chicken but potentially causing cellular disruption in mammalian cells.
Pharmacological Regulation of Neuropathic Pain Driven by Inflammatory Macrophages
Authors: Kiguchi Norikazu , Kobayashi Daichi , Saika Fumihiro , Matsuzaki Shinsuke , Kishioka Shiroh
Published: November 2017

Neuropathic pain can have a major effect on quality of life but current therapies are often inadequate. Growing evidence suggests that neuropathic pain induced by nerve damage is caused by chronic inflammation. Upon nerve injury, damaged cells secrete pro-inflammatory molecules that activate cells in the surrounding tissue and recruit circulating leukocytes to the site of injury. Among these, the most abundant cell type is macrophages, which produce several key molecules involved in pain enhancement, including cytokines and chemokines. Given their central role in the regulation of peripheral sensitization, macrophage-derived cytokines and chemokines could be useful targets for the development of novel therapeutics. Inhibition of key pro-inflammatory cytokines and chemokines prevents neuroinflammation and neuropathic pain; moreover, recent studies have demonstrated the effectiveness of pharmacological inhibition of inflammatory (M1) macrophages. Nicotinic acetylcholine receptor ligands and T helper type 2 cytokines that reduce M1 macrophages are able to relieve neuropathic pain. Future translational studies in non-human primates will be crucial for determining the regulatory mechanisms underlying neuroinflammation-associated neuropathic pain. In turn, this knowledge will assist in the development of novel pharmacotherapies targeting macrophage-driven neuroinflammation for the treatment of intractable neuropathic pain.
Relation among Aromatase P450 and Tumoral Growth in Human Prolactinomas
Authors: García-Barrado María , Blanco Enrique , Iglesias-Osma María , Carretero-Hernández Marta , Catalano-Iniesta Leonardo , Sanchez-Robledo Virginia , Carretero Manuel , Herrero Julio , Carrero Sixto , Carretero José
Published: November 2017

The pituitary gland is part of hypothalamic-pituitary–gonadal axis, which controls development, reproduction, and aging in humans and animals. In addition, the pituitary gland is regulated mainly by hormones and neurotransmitters released from the hypothalamus and by systemic hormones secreted by target glands. Aromatase P450, the enzyme responsible for the catabolization of aromatizable androgens to estrogens, is expressed in different parts of body, including the pituitary gland. Moreover, aromatase P450 is involved in sexual dimorphism where alteration in the level of aromatase can initiate a number of diseases in both genders. On the other hand, the direct actions of estrogens, mainly estradiol, are well known for stimulating prolactin release. Numerous studies have shown that changes in the levels of estrogens, among other factors, have been implicated in the genesis and development of prolactinoma. The pituitary gland can produce estradiol locally in several types of endocrine cells, and it is possible that aromatase could be responsible for the maintenance of the population of lactotroph cells and the modulation of the action of central or peripheral regulators. Aromatase overexpression due to inappropriate gene regulation has clinical effects such as the pathogenesis of prolactinomas. The present study reports on the synthesis of pituitary aromatase, its regulation by gonadal steroids, and the physiological roles of aromatase on pituitary endocrine cells. The involvement of aromatase in the pathogenesis of pituitary tumors, mainly prolactinomas, through the auto-paracrine production of estradiol is reviewed.
Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome
Authors: Sherwin LeeAnne , Ozoji Onyinyechi , Boulineaux Christina , Joseph Paule , Fourie Nicolaas , Abey Sarah , Zhang Xuemin , Henderson Wendy
Published: November 2017

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and bowel dysfunction in the absence of structural abnormality. Diagnosis can be challenging and often leads to extensive medical tests, non-effective therapeutic modalities, and reduced quality of life (QOL). Identifying factors associated with dysfunction have the potential to enhance outcomes. Participants with IBS (n = 41) and healthy volunteers (n = 74) were recruited into this cross-sectional, descriptive, natural history protocol at the National Institute of Health, Clinical Center. Demographic characteristics were self-reported. QOL was assessed with the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire. Statistical analysis included descriptive statistics, factorial ANOVA, and multiple regression. Individuals with IBS reported lower QOL scores across all QOL-subscales compared to healthy controls. Normal-weight women and overweight men with IBS reported the greatest QOL impairment. Body fat percent had confounding effects on the relationship between IBS and QOL. The disparity between QOL scores in participants with IBS by both gender and weight groups may reflect different social pressures perceived by normal and overweight women and men. These findings enhance the recognition of the disparities in patients with chronic symptoms and thereby lead to personalized assessment and interventions to improve their QOL.
Evaluation of PBS Treatment and PEI Coating Effects on Surface Morphology and Cellular Response of 3D-Printed Alginate Scaffolds
Authors: Mendoza García María , Izadifar Mohammad , Chen Xiongbiao
Published: November 2017

Three-dimensional (3D) printing is an emerging technology for the fabrication of scaffolds to repair/replace damaged tissue/organs in tissue engineering. This paper presents our study on 3D printed alginate scaffolds treated with phosphate buffered saline (PBS) and polyethyleneimine (PEI) coating and their impacts on the surface morphology and cellular response of the printed scaffolds. In our study, sterile alginate was prepared by means of the freeze-drying method and then, used to prepare the hydrogel for 3D printing into calcium chloride, forming 3D scaffolds. Scaffolds were treated with PBS for a time period of two days and seven days, respectively, and PEI coating; then they were seeded with Schwann cells (RSC96) for the examination of cellular response (proliferation and differentiation). In addition, swelling and stiffness (Young’s modulus) of the treated scaffolds was evaluated, while their surface morphology was assessed using scanning electron microscopy (SEM). SEM images revealed significant changes in scaffold surface morphology due to degradation caused by the PBS treatment over time. Our cell proliferation assessment over seven days showed that a two-day PBS treatment could be more effective than seven-day PBS treatment for improving cell attachment and elongation. While PEI coating of alginate scaffolds seemed to contribute to cell growth, Schwann cells stayed round on the surface of alginate over the period of cell culture. In conclusion, PBS-treatment may offer the potential to induce surface physical cues due to degradation of alginate, which could improve cell attachment post cell-seeding of 3D-printed alginate scaffolds.
Bivariate Kumaraswamy Models via Modified FGM Copulas: Properties and Applications
Authors: Ghosh Indranil
Published: November 2017

A copula is a useful tool for constructing bivariate and/or multivariate distributions. In this article, we consider a new modified class of FGM (Farlie–Gumbel–Morgenstern) bivariate copula for constructing several different bivariate Kumaraswamy type copulas and discuss their structural properties, including dependence structures. It is established that construction of bivariate distributions by this method allows for greater flexibility in the values of Spearman’s correlation coefficient, ρ and Kendall’s τ .
Spouse Sponsorship Policies: Focus on Serial Sponsors
Authors: Ghafournia Nafiseh , Easteal Patricia
Published: November 2017

Australian citizens or permanent residents can sponsor a spouse or prospective spouse for immigration, and concerns have been raised particularly in regards to serial or repeat sponsorship and the rights to safety for sponsored partners who are victims of domestic violence. There has been little research to date though on this type of family migration. By bringing together immigration statistics and policies from current national and international literature, this paper provides a more nuanced portrayal of patterns of spouse sponsorship and the potential problems of serial sponsorship and protection of those sponsored from intimate partner violence (IPV). We identify the limitation of the existing immigration policy and law for protecting the right of sponsored spouses who are mainly women. Some recommendations to better support these sponsored people are also explored.
Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758)
Authors: Fuochi Virginia , Li Volti Giovanni , Camiolo Giuseppina , Tiralongo Francesco , Giallongo Cesarina , Distefano Alfio , Petronio Petronio Giulio , Barbagallo Ignazio , Viola Maria , Furneri Pio , Di Rosa Michelino , Avola Roberto , Tibullo Daniele
Published: November 2017

Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferative effects of skin mucus derived from Dasyatis pastinaca (Linnaeus, 1758). Our results showed that skin mucus exhibited a significant and specific antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria. Furthermore, we also observed a significant antifungal activity against some strains of Candida spp. Concerning anti-proliferative activity, we showed that fish mucus was specifically toxic for acute leukemia cells (HL60) with an inhibition of proliferation in a dose dependent manner (about 52% at 1000 μg/mL of fish skin mucous, FSM). Moreover, we did not observe effects in healthy cells, in neuroblastoma cells (SH-SY5Y), and multiple myeloma cell lines (MM1, U266). Finally, it exhibited strong expression and activity of chitinase which may be responsible, at least in part, for the aforementioned results.
Microstructures and Mechanical Properties of 7Mn Steel Manufactured by Different Rolling Processes
Authors: Hu Bin , Luo Haiwen
Published: November 2017

We investigated both the microstructures and tensile properties of 7Mn steel, which was either hot-rolled, warm-rolled or cold-rolled before intercritical annealing at 700 °C for 5 h. It can be concluded that the warm-rolled and annealed microstructures are a kind of mixture of hot rolled and cold rolled ones. They are composed of ferrite and retained austenite, the latter having a wide size distribution and two types of morphologies: equiaxed and lamellar. These retained austenite grains are expected to transform to martensite in a more sustainable way—the warm-rolled and annealed steel exhibits the best combination of ultimate tensile strength and total elongation among the three studied steels and a shorter yield point elongation than the cold-rolled one.
Fatigue Crack Growth Behavior of Austempered AISI 4140 Steel with Dissolved Hydrogen
Authors: Nagarajan Varun , Putatunda Susil , Boileau James
Published: November 2017

The focus of this investigation was to examine the influence of dissolved hydrogen on the fatigue crack growth behavior of an austempered low-alloy AISI 4140 steel. The investigation also examined the influence of dissolved hydrogen on the fatigue threshold in this material. The material was tested in two conditions, as-received (cold rolled and annealed) and austempered (austenitized at 882 °C for 1 h and austempered at 332 °C for 1 h). The microstructure of the annealed specimens consisted of a mix of ferrite and fine pearlite; the microstructure of the austempered specimens was lower bainite. Tensile and Compact Tension specimens were prepared. To examine the influence of dissolved hydrogen, two subsets of the CT specimens were charged with hydrogen for three different time periods between 150 and 250 h. All of the CT samples were then subjected to fatigue crack growth tests in the threshold and linear regions at room temperature. The test results indicate that austempering resulted in significant improvement in the yield and tensile strength as well as the fracture toughness of the material. The test results also show that, in the absence of dissolved hydrogen, the crack growth rate in the threshold and linear regions was lower in austempered samples compared to the as-received (annealed) samples. The fatigue threshold was also slightly greater in the austempered samples. In presence of dissolved hydrogen, the crack growth rate was dependent upon the ∆K value. In the low ∆K region (<30 MPa√m), the presence of dissolved hydrogen caused the crack growth rate to be higher in the austempered samples as compared to annealed samples. Above this value, the crack growth rate was increasingly greater in the annealed specimens when compared to the austempered specimens in presence of dissolved hydrogen. It is concluded that austempering of 4140 steel appears to provide a processing route by which the strength, hardness, and fracture toughness of the material can be increased with little or no degradation in the ductility and fatigue crack growth behavior.
Increasing the Fine Flaky Graphite Recovery in Flotation via a Combined MultipleTreatments Technique of Middlings
Authors: Peng Weijun , Qiu Yangshuai , Zhang Lingyan , Guan Junfang , Song Shaoxian
Published: November 2017

As the residual flaky graphite ores become miscellaneous and fine, a single treatment technique for the middlings from the flotation process of graphite ore cannot efficiently recover the valuable graphite in the multistage grinding-flotation technology. In the study, the existence form of graphite and relationship of graphite with the associated gangue minerals were estimated by optical microscope analysis. The results indicated that the fine flaky graphite particles embedded with gangue minerals like a honeycomb, making it difficult to be beneficiated using the typical flotation technique. A combination technique of individual process and concentrated returning for the treatment of middlings was used to increase the graphite recovery based on the co-existing relationship between graphite and gangue minerals in the middlings. The graphite recovery of the final concentrate upgraded from 51.81% to 91.14% at a fixed carbon (FC) content of 92.01% by a beneficiation process consisted of once coarse (94.41% passing 74 μm) and rougher, five stages regrinding and six stages cleaning. The proposed treatment technique for middlings is of great significance to increase the recovery of fine flaky graphite.
A Large Size Chimeric Highly Immunogenic Peptide Presents Multistage Plasmodium Antigens as a Vaccine Candidate System against Malaria
Authors: Lozano José , Varela Yahson , Silva Yolanda , Ardila Karen , Forero Martha , Guasca Laura , Guerrero Yuly , Bermudez Adriana , Alba Patricia , Vanegas Magnolia , Patarroyo Manuel
Published: November 2017

Rational strategies for obtaining malaria vaccine candidates should include not only a proper selection of target antigens for antibody stimulation, but also a versatile molecular design based on ordering the right pieces from the complex pathogen molecular puzzle towards more active and functional immunogens. Classical Plasmodium falciparum antigens regarded as vaccine candidates have been selected as model targets in this study. Among all possibilities we have chosen epitopes of PfCSP, STARP; MSA1 and Pf155/RESA from pre- and erythrocyte stages respectively for designing a large 82-residue chimeric immunogen. A number of options aimed at diminishing steric hindrance for synthetic procedures were assessed based on standard Fmoc chemistry such as building block orthogonal ligation; pseudo-proline and microwave-assisted procedures, therefore the large-chimeric target was produced, characterized and immunologically tested. Antigenicity and functional in vivo efficacy tests of the large-chimera formulations administered alone or as antigen mixtures have proven the stimulation of high antibody titers, showing strong correlation with protection and parasite clearance of vaccinated BALB/c mice after being lethally challenged with both P. berghei-ANKA and P. yoelii 17XL malaria strains. Besides, 3D structure features shown by the large-chimera encouraged as to propose using these rational designed large synthetic molecules as reliable vaccine candidate-presenting systems.
Practical Synthesis of Chalcone Derivatives and Their Biological Activities
Authors: Jung Jae-Chul , Lee Yongnam , Min Dongguk , Jung Mankil , Oh Seikwan
Published: November 2017

Practical synthesis and biological activities of 4-hydroxy-3-methoxy-2-propene derivatives are described. The novel chalcone derivatives were prepared by acid catalysed one-step condensation of 1,3- or 1,4-diacetylbenzene and 1,3,5-triacetylbenzene with 4-hydroxy-3-methoxybenzaldehyde. They were then evaluated for free radical scavenging activity, suppression of lipopolysaccharides (LPS)-induced NO generation, and anti-excitotoxicity in vitro. It was found that all compounds showed good effects for 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, LPS-induced NO generation, and anti-neurotoxicity. Compounds 6 and 7 were potent suppressor of NO generation with the concentration range 10 µM and especially compound 8 showed very potent anti-inflammatory activity with 1 µM. In addition, the di- and tri-acetylbenzyl derivatives 6, 7, and 8 showed enhanced anti-neurotoxicity activity in cultured cortical neurons. Molecular modelling studies to investigate the chemical structural characteristics required for the enhanced biological activities interestingly revealed that compound 8 has the smallest highest occupied molecular orbital-lowest energy unoccupied molecular orbital (HOMO-LUMO) gap, which signifies easy electron and radical transfer between HOMO and LUMO in model studies.
Novel Triazole Hybrids of Betulin: Synthesis and Biological Activity Profile
Authors: Bębenek Ewa , Jastrzębska Maria , Kadela-Tomanek Monika , Chrobak Elwira , Orzechowska Beata , Zwolińska Katarzyna , Latocha Małgorzata , Mertas Anna , Czuba Zenon , Boryczka Stanisław
Published: November 2017

Betulin derivatives containing a 1,2,3-triazole ring possess a wide spectrum of biological activities, including antiviral, anticancer, and antibacterial activity. A series of novel triazoles were prepared by the 1,3-dipolar cycloaddition reaction between the alkyne derivatives of betulin and organic azides. The chemical structures of the obtained compounds were defined by 1H and 13C NMR, IR, and high-resolution mass spectrometry (HR-MS) analysis. The target triazoles were screened for their antiviral activity against DNA and RNA viruses. The cytotoxic activity of the obtained compounds 5a–k and 6a–h was determined using five human cancer cell lines (T47D, MCF-7, SNB-19, Colo-829, and C-32) by a WST-1 assay. The bistriazole 6b displayed a promising IC50 value (0.05 μM) against the human ductal carcinoma T47D (500-fold higher potency than cisplatin). The microdilution method was applied for an evaluation of the antimicrobial activity of all of the compounds. The triazole 5e containing a 3′-deoxythymidine-5′-yl moiety exhibited antibacterial activity against two gram-negative bacteria vz. Klebsiella pneumoniae and Escherichia coli (minimal inhibitory concentration (MIC) range of 0.95–1.95 μM).
Optimization of the Extraction Conditions for Buddleja officinalis Maxim. Using Response Surface Methodology and Exploration of the Optimum Harvest Time
Authors: Xie Guoyong , Li Ran , Han Yu , Zhu Yan , Wu Gang , Qin Minjian
Published: November 2017

The Box-Behnken design was used to evaluate the effects of the methanol concentration (60–100%), liquid to solid ratio (20:1 to 40:1 mL/g) and extraction time (20–40 min) on the yield of 11 constituents from Buddleja officinalis Maxim using ultrasound-assisted extraction. The Derringer’s desirability function approach showed that the modified optimum extraction conditions were: 76% methanol concentration, 33 min extraction time and a 34:1 mL/g solvent to solid ratio. Under these conditions, the experimentally measured yields of the compounds were in good agreement with the predicted values. An accurate and sensitive method was also established using high-performance liquid chromatography with diode-array detection for the simultaneous determination of the 11 compounds in Buddleja officinalis. The newly developed method was used to determine the amounts of bioactive components in Buddleja officinalis during four different growth stages. According to these results, we recommend that the full blossom stage is the best time for harvesting this plant to obtain the highest yield of crude materials.
Use of Nanoparticles for Enhancing the Interlaminar Properties of Fiber-Reinforced Composites and Adhesively Bonded Joints—A Review
Authors: De Cicco Davide , Asaee Zohreh , Taheri Farid
Published: November 2017

This review paper aims at reporting some of the notable works carried out concerning the use of nanoparticles (NPs) as a means of improving the resistance of fiber-reinforced polymer composite materials (FRPs) and adhesively bonded joints (ABJs) to delamination initiation and propagation. Applications of various nanoparticles, such as carbon-based, ceramic-based and mineral-based are discussed. The main properties that have been considered for improving the delamination and fatigue resistance of FRPs are the interlaminar shear strength, fracture toughness, and fracture energy. On the other hand, cohesive and interfacial strengths have been the focused parameters in the works that considered enhancement of ABJs. The reported results indicate that inclusion of NPs in polymeric matrices leads to improvement of various material properties, even though some discrepancies in the results have been noted. Notwithstanding, additional research is required to address some of the issues that have not yet been tackled, some of which will be identified throughout this review article.
Codonopsis lanceolata Water Extract Increases Hepatic Insulin Sensitivity in Rats with Experimentally-Induced Type 2 Diabetes
Authors: Jeong Seong-Yeop , Kang Suna , Kim Da , Park Sunmin
Published: November 2017

We examined the mechanisms and efficacy of Codonopsis lanceolata water extract (CLW) for treating type 2 diabetic (T2DM) symptoms. Partial pancreatectomized (Px) rats, a non-obese T2DM model, were provided high fat diets containing cellulose (control), 0.3% (CLW-L) or 1% CLW (CLW-H) for eight weeks. The positive control group was provided with rosiglitazone (20 mg/kg bw/day). The control group had lower epididymal fat masses than the CLW and the positive control groups, possibly due to urinary glucose loss, although CPT-1 and SIRT-1 expression was higher in the CLW group. CLW-H significantly reduced serum glucose levels and urinary glucose loss compared to the untreated control. The improvement of glucose utilization was associated with a higher fat mass in the CLW-H and positive control groups. Glucose-stimulated insulin secretion was higher in the untreated control than other groups and CLW tightly regulated insulin secretion as much as the positive control, and it was much tighter than the untreated control. Glucose infusion rates were higher during the hyperinsulinemic euglycemic clamp in the CLW and positive controls than the untreated control, and liver glucose outputs were lower during basal and hyperinsulinemic conditions in the CLW and positive control groups than the untreated control group. The increased hepatic insulin sensitivity was associated with enhanced insulin signaling in CLW (pAkt➔pGSK-1β). In conclusion, CLW consumption effectively alleviated diabetic symptoms by improving insulin sensitivity, potentiating hepatic insulin signaling and tightly regulating the insulin secretion capacity in non-obese T2DM rats.
Neurochemical Changes and c-Fos Mapping in the Brain after Carisbamate Treatment of Rats Subjected to Lithium–Pilocarpine-Induced Status Epilepticus
Authors: Marques-Carneiro José , Nehlig Astrid , Cassel Jean-Christophe , Castro-Neto Eduardo , Litzahn Julia , Pereira de Vasconcelos Anne , Naffah-Mazacoratti Maria , Fernandes Maria
Published: November 2017

The administration of lithium–pilocarpine (LiPilo) in adult rats is a validated model reproducing the main clinical and neuropathological features of temporal lobe epilepsy (TLE). Previous studies have shown that carisbamate (CRS) has the property of modifying epileptogenesis in this model. When treated with CRS, about 50% of rats undergoing LiPilo status epilepticus (SE) develop non-convulsive seizures (NCS) instead of convulsive ones (commonly observed in TLE). The goal of this work was to determine some of the early changes that occur after CRS administration, as they could be involved in the insult- and epileptogenesis-modifying effects of CRS. Thus, we performed high-performance liquid chromatography (HPLC) to quantify levels of amino acids and monoamines, and c-Fos immunohistochemical labeling to map cerebral activation during seizures. Comparing rats treated one hour after SE onset with saline (CT), CRS, or diazepam (DZP), HPLC showed that 4 h after SE onset, dopamine (DA), norepinephrine (NE), and GABA levels were normal, whereas serotonin levels were increased. Using c-Fos labeling, we demonstrated increased activity in thalamic mediodorsal (MD) and laterodorsal (LD) nuclei in rats treated with CRS. In summary, at early times, CRS seems to modulate excitability by acting on some monoamine levels and increasing activity of MD and LD thalamic nuclei, suggesting a possible involvement of these nuclei in insult- and/or epileptogenesis-modifying effects of CRS.
Fighting Injustice and Intolerance: Re-Presentations of Race and Religion at the Muhammad Ali Center
Authors: McCormack Michael
Published: November 2017

This article explores the significance of the Muhammad Ali Center as a site where meanings associated with “race” and “religion” are constructed, contested and potentially transformed. The Muhammad Ali Center is examined as an example of an increasing number of cultural institutions (i.e., cultural centers, museums, arts spaces etc.) engaged in the strategic re-presentation of issues of cultural difference and socio-political conflict, towards the ends of promoting social justice and/or human rights. The article draws upon theories and methods in cultural studies, religious studies, and museums studies in order to explore the significance of the representational and curatorial strategies of such cultural institutions for understanding alternative approaches to influencing and/or intervening in public discourses and practices surrounding issues of racial injustice and religious intolerance.
Nearest-Regularized Subspace Classification for PolSAR Imagery Using Polarimetric Feature Vector and Spatial Information
Authors: Zhang Fan , Ni Jun , Yin Qiang , Li Wei , Li Zheng , Liu Yifan , Hong Wen
Published: November 2017

Feature extraction using polarimetric synthetic aperture radar (PolSAR) images is of great interest in SAR classification, no matter if it is applied in an unsupervised approach or a supervised approach. In the supervised classification framework, a major group of methods is based on machine learning. Various machine learning methods have been investigated for PolSAR image classification, including neural network (NN), support vector machine (SVM), and so on. Recently, representation-based classifications have gained increasing attention in hyperspectral imagery, such as the newly-proposed sparse-representation classification (SRC) and nearest-regularized subspace (NRS). These classifiers provide excellent performance that is comparable to or even better than the classic SVM for remotely-sensed image processing. However, rare studies have been found to extend this representation-based NRS classification into PolSAR images. By the use of the NRS approach, a polarimetric feature vector-based PolSAR image classification method is proposed in this paper. The polarimetric SAR feature vector is constructed by the components of different target decomposition algorithms for each pixel, including those scattering components of Freeman, Huynen, Krogager, Yamaguchi decomposition, as well as the eigenvalues, eigenvectors and their consequential parameters such as entropy, anisotropy and mean scattering angle. Furthermore, because all these representation-based methods were originally designed to be pixel-wise classifiers, which only consider the separate pixel signature while ignoring the spatial-contextual information, the Markov random field (MRF) model is also introduced in our scheme. MRF can provide a basis for modeling contextual constraints. Two AIRSAR data in the Flevoland area are used to validate the proposed classification scheme. Experimental results demonstrate that the proposed method can reach an accuracy of around 99 % for both AIRSAR data by randomly selecting 300 pixels of each class as the training samples. Under the condition that the training data ratio is more than 4 % , it has better performance than the SVM, SVM-MRF and NRS methods.
Design and Electro-Thermo-Mechanical Behavior Analysis of Au/Si3N4 Bimorph Microcantilevers for Static Mode Sensing
Authors: Kang Seok-Won , Fragala Joe , Kim Su-Ho , Banerjee Debjyoti
Published: November 2017

This paper presents a design optimization method based on theoretical analysis and numerical calculations, using a commercial multi-physics solver (e.g., ANSYS and ESI CFD-ACE+), for a 3D continuous model, to analyze the bending characteristics of an electrically heated bimorph microcantilever. The results from the theoretical calculation and numerical analysis are compared with those measured using a CCD camera and magnification lenses for a chip level microcantilever array fabricated in this study. The bimorph microcantilevers are thermally actuated by joule heating generated by a 0.4 μm thin-film Au heater deposited on 0.6 μm Si3N4 microcantilevers. The initial deflections caused by residual stress resulting from the thermal bonding of two metallic layers with different coefficients of thermal expansion (CTEs) are additionally considered, to find the exact deflected position. The numerically calculated total deflections caused by electrical actuation show differences of 10%, on average, with experimental measurements in the operating current region (i.e., ~25 mA) to prevent deterioration by overheating. Bimorph microcantilevers are promising components for use in various MEMS (Micro-Electro-Mechanical System) sensing applications, and their deflection characteristics in static mode sensing are essential for detecting changes in thermal stress on the surface of microcantilevers.
Eco-Governmentality: A Discursive Analysis of State-NGOs-Youth Relations in Singapore
Authors: Pey Peili , Islam Md Saidul
Published: November 2017

This article seeks to address the gap in representing micro-level civil society voices and contribute to literature on state-society relations in Singapore’s environmental movement. Given the present constraints of state-NGO communication and cooperation, the state and NGOs negotiate the restrictions by grooming youths as agents of change. Through in-depth interviews, it explores how environmentalism is represented differently through various discourses by the social actors; state, NGOs and youths. By using eco-governmentality as a framework and through discursive analysis, we argue that state-society cooperation in environmentalism is hindered by lack of clear and effective communication channels, as well as expertise and knowledge barriers. In addition, investing in youths has led to an altered dynamic of state-society relations and a greater variety in discourses on environmental advocacy. Owing to the youths’ capability for spreading social awareness and ideas, this is an area that requires open discussion in order to achieve better state-civil society cooperation.
Free Range, Organic? Polish Consumers Preferences Regarding Information on Farming System and Nutritional Enhancement of Eggs: A Discrete Choice Based Experiment
Authors: Żakowska-Biemans Sylwia , Tekień Agnieszka
Published: November 2017

The main purpose of this study was to determine the structure of consumer preferences regarding information on farming system and nutritional enhancement of eggs to verify if consumers are willing to accept products combing sustainability and nutrition related claims. The data was collected within a CAPI (Computer Assisted Personal Interviews) survey on a representative sample of 935 consumers responsible for food shopping. A discrete choice-based conjoint method was selected in eliciting consumer preferences among different product profiles with varying levels of attributes. A hierarchical cluster analysis was used to identify four distinct clusters that differed significantly in terms of importance attached to production system attributes and socio-demographic profiles. The results of the experiment showed that price and farming system had the most significant mean relative importance in shaping consumers’ preferences, while other attributes such as nutrition and health claims, egg size, package size and hen breed were far less important. Free range eggs had the highest relative importance for consumers despite the fact that organic egg production systems are governed by much stricter animal welfare standards. Our segmentation revealed that two of our four clusters may be more easily reached by information on animal welfare related attributes in egg production than the others. The results of our study provide the policy makers and marketing practitioners with insights applicable for communication and pricing strategies for eggs with sustainability claims.
A Pilot Study in Cameroon to Understand Safe Uses of Pesticides in Agriculture, Risk Factors for Farmers’ Exposure and Management of Accidental Cases
Authors: Pouokam Guy , Lemnyuy Album William , Ndikontar Alice , SIDATT Mohamed
Published: November 2017

Chemical pesticides are widely used in Cameroon for agricultural production. In 2015, more than 600 pesticide products were approved for use in various foodstuffs. Much misuse of these chemicals by farmers has been documented in rural and urban settings. This pilot study aims to contribute to the improvement of the health of the population and the environmental preservation by identifying pesticide-poisoning cases, the most incriminated products and critical risk factors of exposure. Questionnaires were administered to pesticide vendors, farmers and health personnel, and observations made on farmers’ practices at their work places. From July to September 2016, 24 villages from five sites, representing the most important agricultural production areas of the five agro-ecological zones of Cameroon, were visited. In total, 519 people were interviewed: 412 farmers, 69 pesticide vendors and 38 health personnel. A total of 180 pesticide formulations out of 610 registered in 2015 were said to be used by farmers. In the 38 health centers visited, 56 cases of pesticide poisonings and intoxications were reported between 2011 and 2016. Paraquat-, glyphosate-, cypermethrin- and metalaxyl-formulated pesticides were the most incriminated. In total, 78% of poisoning cases were accidental, 12% suicide attempts, 4% criminal. Entry of pesticide products from neighboring countries needs to be better regulated, and the quality of pesticides sold on the market should be monitored periodically. Empty pesticide containers should be recuperated from smallholder farmers. Authorities should set up a harmonized pesticide-poisoning management procedure, and create a toxico-vigilance system for surveillance cases and preventive actions.
Thermal Modeling of Comet-like Objects from AKARI Observation
Authors: Bach Yoonsoo P. , Ishiguro Masateru , Usui Fumihiko
Published: November 2017

We investigated the physical properties of the comet-like objects 107P/(4015) Wilson–Harrington (4015WH) and P/2006 HR30 (Siding Spring; HR30) by applying a simple thermophysical model to the near-infrared spectroscopy and broadband observation data obtained by the AKARIsatellite of JAXA when they showed no detectable comet-like activity. We selected these two targets because the tendency of thermal inertia to decrease with the size of an asteroid, which has been demonstrated in recent studies, has not been confirmed for comet-like objects. It was found that 4015WH, which was originally discovered as a comet but has not shown comet-like activity after its discovery, has effective size D = 3.74–4.39 km and geometric albedo

with thermal inertia

J m−2 K−1

. The corresponding grain size is estimated as 1–3 mm. We also found that HR30, which was observed as a bare cometary nucleus at the time of our observation, has

km and

with

J m−2 K−1

. We conjecture the pole latitude

. The results for both targets are consistent with previous studies. Based on the results, we propose that comet-like objects are not clearly distinguishable from their asteroidal counterparts on the D–Γ plane.
Infrared Photometric Properties of 709 Candidate Stellar Bowshock Nebulae
Authors: Kobulnicky Henry A. , Schurhammer Danielle P. , Baldwin Daniel J. , Chick William T. , Dixon Don M. , Lee Daniel , Povich Matthew S.
Published: November 2017

Arcuate infrared nebulae are ubiquitous throughout the Galactic Plane and are candidates for partial shells, bubbles, or bowshocks produced by massive runaway stars. We tabulate infrared photometry for 709 such objects using images from the Spitzer Space Telescope, the Wide-field Infrared Explorer, and the Herschel Space Observatory (HSO). Of the 709 objects identified at 24 or 22 μm, 422 are detected at the HSO 70 μm bandpass. Of these, only 39 are detected at HSO 160 μm. The 70 μm peak surface brightnesses are 0.5–2.5 Jy arcmin−2. Color temperatures calculated from the 24 to 70 μm ratios range from 80 to 400 K. Color temperatures from 70 to 160 μm ratios are systematically lower, 40–200 K. Both of these temperature are, on average, 75% higher than the nominal temperatures derived by assuming that dust is in steady-state radiative equilibrium. This may be evidence of stellar wind bowshocks sweeping up and heating—possibly fragmenting but not destroying—interstellar dust. Infrared luminosity correlates with standoff distance, R
0, as predicted by published hydrodynamical models. Infrared spectral energy distributions are consistent with interstellar dust exposed to either single radiant energy density,

(in more than half of the objects) or a range of radiant energy densities U
min = 25 to U
max = 103–105 times the mean interstellar value for the remainder. Hence, the central OB stars dominate the energetics, making these enticing laboratories for testing dust models in constrained radiation environments. The spectral energy densities are consistent with polycyclic aromatic hydrocarbon fractions

in most objects.
Magnetar-like X-Ray Bursts Suppress Pulsar Radio Emission
Authors: Archibald R. F. , Burgay M. , Lyutikov M. , Kaspi V. M. , Esposito P. , Israel G. , Kerr M. , Possenti A. , Rea N. , Sarkissian J. , Scholz P. , Tendulkar S. P.
Published: November 2017

Rotation-powered pulsars and magnetars are two different observational manifestations of neutron stars: rotation-powered pulsars are rapidly spinning objects that are mostly observed as pulsating radio sources, while magnetars, neutron stars with the highest known magnetic fields, often emit short-duration X-ray bursts. Here, we report simultaneous observations of the high-magnetic-field radio pulsar PSR J1119−6127 at X-ray, with XMM-Newton and NuSTAR, and at radio energies with the Parkes radio telescope, during a period of magnetar-like bursts. The rotationally powered radio emission shuts off coincident with the occurrence of multiple X-ray bursts and recovers on a timescale of ∼70 s. These observations of related radio and X-ray phenomena further solidify the connection between radio pulsars and magnetars and suggest that the pair plasma produced in bursts can disrupt the acceleration mechanism of radio-emitting particles.
Block-induced Complex Structures Building the Flare-productive Solar Active Region 12673
Authors: Yang Shuhong , Zhang Jun , Zhu Xiaoshuai , Song Qiao
Published: November 2017

Solar active region (AR) 12673 produced 4 X-class, 27 M-class, and numerous lower-class flares during its passage across the visible solar disk in 2017 September. Our study is to answer the questions why this AR was so flare-productive and how the X9.3 flare, the largest one of the past decade, took place. We find that there was a sunspot in the initial several days, and then two bipolar regions emerged nearby it successively. Due to the standing of the pre-existing sunspot, the movement of the bipoles was blocked, while the pre-existing sunspot maintained its quasi-circular shaped umbra only with the disappearance of a part of penumbra. Thus, the bipolar patches were significantly distorted, and the opposite polarities formed two semi-circular shaped structures. After that, two sequences of new bipolar regions emerged within the narrow semi-circular zone, and the bipolar patches separated along the curved channel. The new bipoles sheared and interacted with the previous ones, forming a complex topological system, during which numerous flares occurred. At the highly sheared region, a great deal of free energy was accumulated. On September 6, one negative patch near the polarity inversion line began to rapidly rotate and shear with the surrounding positive fields, and consequently the X9.3 flare erupted. Our results reveal that the block-induced complex structures built the flare-productive AR and the X9.3 flare was triggered by an erupting filament due to the kink instability. To better illustrate this process, a block-induced eruption model is proposed for the first time.