bluuebunny/crossref_metadata_2025 huggingface dataset:
Determining the value contribution of emicizumab (hemlibra®) for the prophylaxis of haemophilia a patients without inhibitors in Spain by multi-criteria decision analysis (MCDA)
Authors: Álvarez Eva , Álvarez-Román María Teresa , Cuervo-Arango Ignacio , Núñez Ramiro , Pérez-Santamarina Rafael , Poveda José Luis , Romero José Antonio , Queralt Gorgas Torner María , Quintero Pablo , Vañó Luis , Tort Marina
Published: December 2023

Objective: Determining the value of emicizumab compared to octocog alfa (OA) and efmoroctocog alfa (EA) in the prophylaxis of severe Haemophilia A (HA) patients without inhibitors using Multi-Criteria Decision Analysis (MCDA).
Methodology: The EVIDEM framework adapted to orphan drugs and weighted by a sample of 98 national and regional Spanish evaluators was used. Two structured evidence matrices were developed: emicizumab against octocog alfa (OA) and emicizumab against efmoroctocog alfa (EA). A multidisciplinary team of haemophilia experts rated each one of the criteria. Mean and standard deviation was calculated by each criterion and discussed among all participants.
Results: Relative quality of life and therapeutic benefit were the most valued criteria for emicizumab. HA without inhibitors was perceived as a serious disease (4.3±0.5) with unmet needs, especially for severe HA patients with higher probability of FVIII inhibitors development (3.3±0.9). When compared with OA and EA, emicizumab had higher therapeutic benefit (4.3±0.9 emicizumab/OA, 4.2±1.0 emicizumab/EA) with greater patient reported outcomes (4.0±1.2 emicizumab/OA, 4.3±0.9 emicizumab/EA) and relative efficacy (3.7±1.6 emicizumab/OA and 3.3±1.4 emicizumab/EA). Comparative safety and tolerability were perceived as similar for all the alternatives (2.1±2.1 emicizumab/OA and 1.6±1.5 emicizumab/EA). Quality of evidence (3.9±0.9 emicizumab/OA and 3.8±0.8 emicizumab/EA) and expert consensus (3.0±1.3) were also positive. All contextual criteria were valued positively for emicizumab.
Conclusions: Emicizumab adds higher therapeutic value and improves patients’ quality of life compared to the current prophylaxis agents for severe HA without inhibitors and satisfies important unmet needs such as higher efficacy, improved posology and subcutaneous administration.
Keywords: haemophilia A; drug value; multicriteria decision analysis, emicizumab
¿Qué resultado económico y cuantificable se puede obtener de la puesta en marcha de un proyecto de sostenibilidad medioambiental?
Authors: Calero Remedios , Roldán Diego , Bleda Manolo , Díaz Francisca , Losa Ángel , Pérez Juan
Published: December 2023

Objetivo. Ante una mayor demanda de compromiso medioambiental de las instituciones públicas y los organismos sanitarios, se busca analizar los resultados de una experiencia real de implantación, con medios propios, de un proyecto de sostenibilidad medioambiental, en este caso, la Gerencia de Atención Integrada de Hellín (Albacete).
Método. Tras la revisión de la literatura, se enumeran las medidas adoptadas y se aporta un análisis descriptivo de los resultados del proyecto recogidos en un Cuadro de Mando Medioambiental
Resultados. Se concretan en una disminución de medio millón de kilovatios anuales y un ahorro de 120.000 euros al año en electricidad.
Conclusiones. Los resultados, económicos y cuantificables, avalan las iniciativas emprendidas y muestran que es posible y fructífera la apuesta de las organizaciones sanitarias por la implantación de medidas medioambientales.
Palabras clave. Hospital verde, Compromiso medioambiental, Cambio climático.
Comparación de los costes del tratamiento habitual del dolor agudo moderado a intenso con infusión intravenosa frente al sistema de comprimidos sublinguales de sufentanilo en España
Authors: Malmierca García María Isabel , López García María Elena , Pascual Ibarra Ana Loreto , de Frutos Parra Raúl , Renedo Fernández Ainhoa , Lebrero Pastor Maite , Castellanos Amigo Isabel , Muñecas Herreras Begoña , Aguilera Celorio Luciano
Published: December 2023

OBJETIVOS: Comparar los costes del tratamiento del dolor agudo postoperatorio (DAP) con opioides intravenosos (IV) frente al sistema de comprimidos sublinguales de sufentanilo (SCSS).
MATERIAL Y MÉTODOS: Se realizó un análisis de los costes asociados a los protocolos DAP de la organización sanitaria integrada (OSI) de Basurto, perteneciente a Osakidetza, comparando la administración mediante el SCSS combinado con analgésicos IV en un horizonte temporal de 72 horas frente a la infusión IV de opioides (morfina-M- o tramadol-T-) en combinación con analgésicos. Las cirugías en las que se realizó este estudio fueron aquellas para las que estaba prevista una estancia en la unidad de cuidados polivalentes intermedios de al menos 24 horas para el control del DAP. Se reclutó un total de 20 pacientes. En dichos pacientes, la pauta analgésica adyuvante empleada fue paracetamol (P), ondansetrón (O) y metamizol (MET). El análisis se realizó desde la perspectiva del sistema nacional de salud (SNS) considerando costes farmacológicos, asistenciales, de preparación y administración de la medicación (€, 2017). Para validar los resultados, se realizó un análisis de sensibilidad de los parámetros claves.
RESULTADOS: El coste farmacológico fue superior para el SCSS (110,16 € SCSS+P, 109,61 € SCSS+O y 111,89 € SCSS+MET+O frente 7,01 € M+P, 6,46 € M+O y 9,07 € T+MET+O). Sin embargo, teniendo en cuenta además el coste relacionado con el uso de fungibles y el tiempo de enfermería, el tratamiento con el SCSS mostró un coste total entre 113,70 € y 115,98 € mientras que los opioides mediante elastómero supusieron entre 160,16 € y 162,77 €. SCSS en combinación con analgésicos IV (SCSS+P, SCSS+O y SCSS+MET+O) mostró analgesia efectiva no inferior al comparador y redujo los costes en un 28,91%, 29,01% y 28,74% frente a los tratamientos de analgesia con infusor de M+P, M+O y T+MET+O respectivamente.
CONCLUSIÓN: Partiendo de la base de que ambos tratamientos cuentan con una eficacia y seguridad similares, el SCSS es una opción menos costosa y supone una menor carga asistencial para el SNS por lo que se puede recomendar su uso frente a la administración pautada con opioides mediante elastómeros.
PALABRAS CLAVE: Dolor moderado o intenso, estudio de costes, sufentanilo, opiáceos, opioides, morfina
Impacto presupuestario del rescate precoz con surfactante pulmonar porcino en recién nacidos prematuros con Síndrome de Distrés Respiratorio en España
Authors: Solozabal Míriam , López Sanromà Marta , Pérez Román Inés , Querol Dolors , Galindo José Vicente , Pretola Serena
Published: December 2023

Objetivo: Estimar el impacto presupuestario del rescate precoz con surfactante (FiO2>0,3), en recién nacidos con presión positiva continua en las vías aéreas (CPAP), como parte del manejo del Síndrome de Distrés Respiratorio (SDR) en España.
Métodos: Se desarrolló un árbol de decisión para estimar el consumo de recursos asociado al rescate precoz con surfactante pulmonar porcino (poractant alfa), administrado con una técnica mínimamente invasiva (LISA), respecto al soporte respiratorio con CPAP solo. El impacto se realizó en un horizonte temporal de un año, desde la perspectiva del Sistema Nacional de Salud. Anualmente, nacen una media de 759 y 1.712 prematuros de 25-28 y 29-32 semanas de edad gestacional (EG) en España. Se consideraron los costes del tratamiento (€2019) y la incidencia de complicaciones. La robustez del modelo se analizó mediante un análisis de sensibilidad determinístico y otro probabilístico (ASP).
Resultados: El rescate precoz con surfactante implicó un ahorro anual de 2.265.456,06€ en la cohorte de 25-28 semanas EG y un ahorro de 1.393.075,83€ en la de 29-32 semanas EG. El ASP mostró que el rescate precoz con surfactante tiene una probabilidad del 63% de generar ahorros en la cohorte de 25-28 semanas EG y del 59% en los recién nacidos de 29 a 32 semanas EG. El principal componente del coste fue el manejo de las complicaciones.
Conclusiones: El rescate precoz con surfactante mejora el pronóstico y reduce la mortalidad, generando un ahorro anual de 3.658.531,89€ en los prematuros con SDR, que reciben soporte respiratorio con CPAP, de entre 25 y 32 semanas EG.
Palabras clave: síndrome de distrés respiratorio; presión positiva continua en las vías aéreas; surfactante pulmonar; poractant alfa; ventilación mecánica.
Multilevel SEM in Mplus (Free with Course Purchase)
Authors: Zhang Zhen
Published: December 2023

This seminar introduces the Mplus multilevel latent variable modeling framework and describes topics including multilevel variance and effect decomposition, and random and fixed effects (including random slopes), and then proceeds to explore multilevel path analysis, multilevel CFA including multilevel bi-factor models, and multilevel SEM, including approaches for handling strong correlations at the between-group level, indirect effects (multilevel mediation), interaction effects (multilevel moderation), and conditional indirect effects (multilevel moderated mediation). An official Instats certificate of completion is provided at the conclusion of the seminar. For European PhD students, the seminar offers 2 ECTS Equivalent point.
Meta-Analysis for Organization and Management Research
Authors: Yuan Zhenyu
Published: December 2023

This seminar introduces meta-analysis, including methods for psychometric meta-analysis and meta-regression with are useful for the social and health sciences. This three-day seminar will equip you with both a comprehensive understanding of this important method and also practical knowledge of how to conduct a meta-analytic reviews, with a special emphasis on organizational and management/business research. An official Instats certificate of completion is provided at the conclusion of the seminar. The seminar offers 2 ECTS Equivalent points for European PhD students.
Survey Design and Analysis
Authors: Weijters Bert
Published: December 2023

This seminar will teach you the most current best practices for survey design and analysis. This involves conceptually and statistically modeling, through hands-on exercises, measurement as (a) the selection of indicators of latent constructs, (b) data collection as a psychological process of survey responding, and then (c) specifying and testing measurement models that are able to adequately reflect this process (using CFA). Day 1 offers a conceptual introduction and then a variety of hands-on applications are covered in Mplus on Day 2, and lavaan in R on Day 3. An official Instats certificate of completion is provided at the conclusion of the seminar. The seminar offers 2 ECTS Equivalent points for European PhD students.
Making Beautiful And Effective Maps In R
Authors: Nowosad Jakub
Published: December 2023

The aim of the course is to show you how to use R to make pretty, yet appealing maps using the R programming language. Several R packages related to spatial data processing and visualization will be introduced during the course. The course will teach you how create publication-ready static maps, animated maps, interactive maps, and simple map applications using a mixture of lectures and computer exercises. An official Instats certificate of completion is provided at the conclusion of the seminar, and European PhD students receive 1.5 ECTS Equivalent points.
A Gentle Introduction to Python
Authors: Bednall Timothy
Published: December 2023

This seminar teaches the basics of Python without any assumed prior knowledge of statistics or programming. Over the course of two days you'll learn how to load, save, and explore data, present your work, manipulate data, and create figures/plots. We will also showcase basic examples of using Python for prediction with regression analysis, classification, dimensionality reduction, and clustering. An official Instats certificate of completion is provided at the conclusion of the seminar. For European PhD students, the seminar offers 2 ECTS Equivalent points.
Introduction to Necessary Condition Analysis (NCA) - Free Seminar
Authors: Dul Jan
Published: December 2023

Necessary Condition Analysis (NCA) understands a cause as a necessary (but not sufficient) condition, rather than a probabilistic cause (as in regression analysis). “Necessary” means that an outcome will not occur without a certain level of the condition, independent of the rest of the causal structure (thus the condition can be a “bottleneck”, “critical factor”, “constraint”). NCA is rapidly entering a variety of research fields and can be used as a stand-alone method or in combination with other methods (e.g., multiple regression analysis, structural equation modeling, qualitative comparative analysis). This two-part seminar will introduce you to NCA and then demonstrate the use of R for conducting NCA analysis for your research. An official Instats certificate of completion is provided at the conclusion of the seminar. The seminar offers ECTS Equivalent points for European PhD students.
Beyond Polarity: The Potential Applications and Impacts of Sentiment Analysis and Emotion Detection
Authors: Tuama Murteza Hanoon , Mashloosh Wahhab Muslim , Albehadili Hayder M. , Alazzawi Murtadha , Al-shareeda Mahmood A.
Published: December 2023

Opinion mining and emotion detection are two important techniques in natural language processing that have gained significant attention in recent years. Opinion mining is the process of identifying and extracting subjective information from text, such as opinions, attitudes, and emotions, while emotion detection is the process of identifying and extracting emotions from text. These techniques have a wide range of applications in various domains, including social media analysis, customer feedback analysis, and product reviews. This paper provides an overview of opinion mining and emotion detection techniques in natural language processing. We discuss the various approaches and methods used in opinion mining and emotion detection, including machine learning, deep learning, and natural language processing techniques. We also explore the challenges and limitations of these techniques, including the subjectivity of language, cultural differences, and the lack of labeled data. Furthermore, we examine the current state of the art in opinion mining and emotion detection, highlighting recent research and developments in these areas. We also discuss the potential applications of these techniques in various domains, including marketing, healthcare, and social media analysis. Overall, this paper provides a comprehensive overview of opinion mining and emotion detection in natural language processing. It provides insights into the methods, challenges, and potential applications of these techniques, and highlights the importance of these techniques in understanding and analyzing subjective information in text.
Enhancement the Security by creating ontology-based Trust Management using Semantic Web tools
Authors: Al-shadood Wurood
Published: December 2023

The most traditional policy models which do not consider dynamic nature of distribute systems and the limitation in addressing issues like adaptability, extensibility, and reasoning over security policies. The main cause of the flexibility and scalability issues in the environments of the Internet and dynamic networks is that there is no central control over the environments, and users are not predetermined. As a result, security and trust issues become critical in the various systems; enhancing the security of these environments would require adding trust to the existing security infrastructures. Few trust models have taken into account the semantic relationship for pervasive elements, despite the fact that numerous models have been proposed to address trust issues in dynamic environments; especially those who related to trust categories. In our work, we solve issues resulted from security and tracking the dynamics of participating communication devices in dynamic distributed networks. Through using ontology for trust management which it is define vocabularies used to described and represented an area of knowledge. For representation, we used semantic web's tools to represent the domain of the dynamic environment and we improv that the reasoning succusses in inference the trusted device and user exactly where we do query.
CHARACTERISTICS OF PATIENTS WITH EPILEPSY AND VARIOUS FORMS OF CEREBRAL PALSY
Authors: Magalov Sh.I. , Mammadbayli A.K. , Taghiyeva M.R.
Published: December 2023

The course of cerebral palsy is often complicated by epilepsy. The problem of the relationship of these diseases is quite relevant in pediatric neurology. According to the literature, the frequency of epilepsy in patients with cerebral palsy is 15-45%. The aims of this study were to analyze and describe the prevalence and characteristics of epilepsy in children with cerebral palsy based on the materials of the Children's Neurological Hospital in Baku for 2013-2017 years. In general, epilepsy in children with cerebral palsy tend to have an earlier onset, low frequency of generalized seizures, polytherapy and higher incidence of refractory seizures. Seizures develops mainly before 2 years and mostly in tetraplegic form of cerebral palsy.
COGNITIVE IMPAIRMENT IN PATIENTS WITH ATRIAL FIBRILLATION
Authors: Hairieva M.F. , Gafurov B.G.
Published: December 2023

84 patients with coronary heart disease (CHD), including 20 patients without atrial fibrillation (AF) and 64 patients with AF, were examined using a set of neuropsychological tests aimed at assessing cognitive functions (MMSE, FAB, clock face drawing, memorization of 10 words). The latter were divided into subgroups with permanent (22 patients) and paroxysmal (42 patients) forms of AF. The results showed that patients with CHD and AF develop more pronounced cognitive impairment (Cİ), compared to CHD without rhythm disturbance. In this case, the paroxysmal variant of AF is associated with more pronounced Cİ than the permanent one. The authors conclude that Cİ in CHD with AF requires great attention both in terms of diagnosis and treatment.
ANÁLISE DOS CONTEÚDOS DE ZOOLOGIA PRESENTES NOS LIVROS DIDÁTICOS DE BIOLOGIA DO PNLD 2018-2020
Authors: Zocche Elis Regina dos Reis , Do Bomfim Darcy Alves , Fracaro Flávia Andréia Fracaro
Published: December 2023

Os livros didáticos são considerados por grande número de professores como a principal ferramenta de ensino e em algumas regiões chegam a ser o único recurso disponível. Frente a essa importância e também às diversas críticas em relação aos conteúdos propostos nos livros didáticos, fazem-se necessários trabalhos científicos que averiguem a qualidade desses materiais e possam servir de referência para pesquisas futuras. A pesquisa realizada teve como objetivo analisar os conteúdos de zoologia presente nas coleções de livros didáticos de Biologia ofertados pelo Programa Nacional do Livro Didático para o triênio 2018-2020. A análise teve como base alguns critérios pré-estabelecidos que tornaram possível classificar a qualidade dos conteúdos ofertados por esses livros. Com a análise, percebe-se que todos os conteúdos estavam corretos, porém, apresentaram algumas imperfeições. O uso de analogias esteve presente em todas as coleções, considerando que estas são de grande importância para facilitação da assimilação de conteúdo; textos complementares estiveram ausentes em dois livros; e foram encontradas duas atividades práticas que ofereciam riscos. Dessa forma, os resultados desta pesquisa ressaltam a necessidade de professores realizarem cuidadosamente suas análises no momento de escolherem os livros didáticos que serão utilizados nas turmas do ensino médio.
IMPLEMENTASI METODE QUR’ANI SIDOGIRI DALAM MENUNJANG KEMAMPUAN MEMBACA AL-QUR’AN DI MADRASAH IBTIDA’IYAH
Authors: Hadi Syamsul , Fina Surya Anggraini
Published: December 2023

Madrasah Ibtida’iyah Al-Jawahir mulai menerapkan metode baca Qur’an yang dicetuskan oleh Ponpes Sidogiri yang merupakan salah satu pesantren bercorak salaf yang ada di Jawa Timur dengan metode baca Qur’an yang bernama “Metode Qur’ani Sidogiri”. Penelitian ini menggunakan jenis penelitian kualitatif dengan pendekatan studi kasus yang dilakukan dengan observasi, wawancara, dan dokumentasi. Tujuan penelitian ini adalah: (1) Untuk mengetahui kualitas kemampuan membaca Al-Qur’an di Madrasah Ibtida’iyah Al-Jawahir sebelum diterapkan Metode qur’ani Sidogiri, (2) Untuk mendeskripsikan penerapan Metode tersebut dalam menunjang kemampuan membaca Qur’an santri di Madrasah Ibtida’iyah Al-Jawahir. (3) Untuk menganalisis faktor penghambat dalam penerapan Metode tersebut di Madrasah Ibtida’iyah Al-Jawahir. Hasil penelitian ini menunjukkan: 1) sebelum diterapkannya MQS, belum ada penerapan khusus tentang pembelajaran di bidang Al-Qur’an sehingga beberapa santri baik itu yang masih aktif atau yang sudah lulus tidak dapat dijamin kualitasnya dalam bidang membaca Al-Qur’an. 2) MQS mulai diterapkan sejak tahun 2019 dan proses pembelajaran dilaksanakan di pagi hari serta dimasukkan dalam jadwal aktif pembelajaran di jam pertama dengan tujuan agar santri lebih fokus dalam mengikuti pelajaran 3) Adapun faktor penghambat dari proses pelaksanaan MQS yaitu mengenai masalah kedisplinan peserta didik yang masih kurang tertib dalam proses pembelajaran. Dalam hal ini guru dituntut agar dapat mengatasi masalah tersebut diantaranya dapat dilakukan dengan cara memberikan Reward & Punishment
Comparison of 3% Normal Saline Nebulization versus Steroid Nebulization in the Treatment of Bronchiolitis
Authors: Suleman Muhammad , Sadiq Faizan , Qasim Khan Muhammad , Jabar Abdul , Khan Arooj , Musa Nighat
Published: December 2023

Background: Bronchiolitis is a leading cause of hospitalization in infants. This study aimed to compare the efficacy of 3% normal saline nebulization with steroid nebulization in the treatment of bronchiolitis.
Methods: Conducted at the Department of Pediatrics, Mardan Medical Complex, Mardan from November 15, 2022, to March 15, 2023, this randomized controlled trial involved 60 infants aged 3 to 12 months diagnosed with bronchiolitis. They were equally randomized into two groups: Group-A received 3% normal saline nebulization, while Group-B was treated with steroid and salbutamol nebulization, administered three times daily. Efficacy assessments were made at 0, 12, 24, 48, and 72 hours using the respiratory distress assessment instrument. The primary outcome was defined as the number of patients discharged from the hospital within ≤ 72 hours after starting treatment. The chi-square test was used for statistical comparison, with p ≤0.05 considered significant.
Results: The mean±SD age in the study was 6.91±2.41 months, with a gender distribution of 55% male and 45% female. The study revealed that a significantly higher number of infants in Group-A were discharged from the hospital within ≤ 3 days compared to Group-B (90% vs 63.33%, p=0.01). Additionally, Group-A had a significantly shorter mean length of hospital stay (2.76±0.51 days) compared to Group-B (3.58±0.82 days, p=0.00).
Conclusion: Nebulization with 3% normal saline was found to be significantly more effective than steroid nebulization in reducing the severity of bronchiolitis and the duration of hospitalization in infants aged between 3-12 months.
The use of a tracer study toadvancethe undergraduate program at the Royal University of Phnom Penh
Authors: Chealy CHET , Serey SOK , Chovy VONG , Vanny SOK
Published: December 2023

It has beenrecognized that academic performance does not always help students to seek decent work. Tracer studies have become popular at Higher Education Institutions (HEIs) for tracking and evaluating student progress beyond graduationandare recommended to be conducted regularly onindividuals, groups, or departments over time.
Significance of Professorship Implementation at Higher Education Instructions (HEIs) in Cambodia
Authors: Chealy CHET , Reno THOU , Serey SOK , Sethik RATH
Published: December 2023

A well-known saying by MatshonaDhliwayo is, “Life is a thorough university; pain and hardship are its distinguished professors.” In most countries, a professor is the highest academic rank at a university
THE EFFECT OF COMPENSATION, WORK DISCIPLINE, AND MOTIVATION ON EMPLOYEES’ WORK PRODUCTIVITY
Authors: Burhanudin  , Risman Hariwibowo  , Muhammad Miftahuddin
Published: December 2023

This research aims to examine the influence of compensation on employee work productivity, to investigate the impact of work discipline on employee work productivity, and to assess the effect of motivation on employee work productivity.  The participants in this study consisted of 43 employees from PT.  Titipan Ilahi located in Denpasar, Bali. Data were collected using a questionnaire and analyzed using multiple linear regression. The research findings reveal that:  (1) compensation significantly influences employee work productivity; (2) work discipline does not significantly affect employee work productivity; and (3) motivation significantly affects employee work productivity
THE INFLUENCE OF GREEN IMAGE, GREEN COMMUNICATION ON SUSTAINABILITY REPORT WITH FINANCIAL PERFORMANCE VARIABLES AS MODERATION
Authors: Tamrin Lanori  , Usmar  , Selfiani
Published: December 2023

This study aims to examine the effect of green image and green communication on sustainability report with the financial performance as a moderating variable. This research method uses quantitative and secondary data. The sample used in this study is manufacturing companies listed on the IDX in 2020 with the measurement of sustainability report, green image using an index, green communication using an index, and financial performance.   Specific objectives: To analyze and examine the effect of green image on Sustainability Report, the effect of green communication on Sustainability Report, the effect of financial performance moderating the relationship between green image and Sustainability Report, the effect of financial performance moderating the relationship between green communication and Sustainability Report.Research Method: Population and sample are manufacturing companies using data analysis methodology, namely descriptive statistics, assumption tests, data normality tests to hypothesis testing. Research Results: Green Image is proven to have a positive effect on Sustainability Report, Green Communication is proven to have a positive effect on Sustainability Report, Financial Performance moderates or strengthens the relationship between green image and sustainability report and Financial Performance moderates or strengthens the relationship between green communication and sustainability report.
DETERMINANTS OF GOING CONCERN AUDIT OPINIONS IN REAL ESTATE AND PROPERTY COMPANIES LISTED ON THE IDX
Authors: Jenny Zain  , Bunga Hanggraini Meiviandra  , Trica Angkat  , Widodo Sinaga  , Syahputra
Published: December 2023

This study aims to determine the effect of Audit Quality, Company Size, KAP Reputation and Audit Tenure on Going Concern Audit Opinions. This research is focused on Real Estate and Property companies listed on the IDX in 2020-2022 with a total of 81 samples. The data analysis technique used is using SPSS software with the aim of obtaining accurate calculation results and facilitating proper data processing. The results of this study are audit quality, KAP reputation, and audit tenure have no effect on going concern audit opinion. Meanwhile, company size has a significant effect on going concern audit opinion.
SELF-CONFIDENCE FOR PERSONS WITH PHYSICAL DISABILITIES IN SENTRA BUDI PERKASA PALEMBANG THROUGH ISLAMIC PSYCHOTRAPHY APPROACH
Authors: Adela Zinta Sari  , Kamila Istakhana  , Sinar Saprini  , Ardiansyah  , Annisa Al-Isra  , Sunarsih  , Dea Ayu Sapitri  , Mutiara Kurnia Sari  , Quina  , Raden Azty Afifadyandi  , Afifah Indah Sari  , Ade Rizki  , Sintya Merinda  , Faizah Nurul Aliyah  , Pipit Kun Maya  , Ayi S. Ruqayyah  , Kasiyanti
Published: December 2023

This study aims to determine how the level of confidence for physical disabilities by the Islamic psychotherapy approach at the Budi Perkasa Sentra Palembang. The research method used is the method of qualitative research with a phenomenological approach. Subjects in research are two people (adults) with physical disabilities in the Budi Perkasa Sentra of N (male) and H (female). Methods of data collection using interviews, observation, and documentation. The results of this study conclude that subjects are able to accept their current conditions, in the sense of no inferiority or embarrassment of the limitations of possession. Subjects have good confidence, they are aware of the disadvantages they have, but they are also aware of the excess tucked inside themselves are aware of the disadvantages they have, but they are also aware of the excess tucked in themselves. Factors that affect the sense of confidence is because social support that always encourages and encourages them in every situation, and also they believe and represent Allah SWT, they believe that every human being is inseparable from excess and disadvantage.
CYBERBULLYING YOUTH ON SOCIAL MEDIA
Authors: M. Jorgie Arroyandy  , Sandro Saragi  , Muhammad Akbar  , M Iqbal Andriano Bengkulah  , Jimi Mardiansyah  , Muhammad Naufal Luthfi  , Mahesa Belanti  , Siti Fatimah  , Bayu Sefryian Saputra
Published: December 2023

The purpose of this study is to analyze how often perpetrators carry out cyberbullying actions. The type of research used is a type of survey. Respondents resulting from the survey amounted to N = 58 who were determined using data collection carried out by distributing online questionnaires through the Google form. Meanwhile, this study used the Mixed Method method with a sequential explanatory design. The results of this study can be concluded that most cyberbullying perpetrators have carried out cyberbullying and the majority are involved in low-level cyberbullying with an age range of 17-18 years.
THE INFLUENCE OF MOTIVATION ON ACADEMIC PERFORMANCE OF MUSLIM YOUTH IN ISLAMIC UNIVERSITIES
Authors: Rizki Amaliyah  , Chairunnisa  , Wahyu Agung Hidayatullah  , Nurrina Zulfa  , Aria Mahardika  , Nadia Safana  , Anita  , Rendi Praja Pratama  , Reira Izzatunisa  , Cindy Destika  , Hanna Wirena Putri  , Revalina Stevy
Published: December 2023

This study aims to determine the relationship between motivation and academic performance of Muslim youth at Islamic universities. Respondents involved in this study were 104 respondents. The respondents involved in this study were 104 respondents who were randomly selected using data collection techniques used were questionnaires using scales as data collection tools, namely using motivation and academic performance scales. By using correlational quantitative research methods. The results of this study indicate that motivation affects the academic performance of Muslim youth. Because motivation is an encouragement, meaning that where behavior can influence a person's efforts so that his heart acts for him to do something so that there are results. Motivation is very important because it can support a person's behavior so that he wants to work hard, so that he can produce the best.
El aborto inducido: pacientes, no números
Authors: Rodríguez Navarro Deivys , Sosa Rodríguez Anisley , Hernández Say Yoanis
Published: December 2023

Introducción: La práctica del aborto es tan antigua como la misma humanidad; los pueblos primitivos permitían el aborto, el cual era reconocido como un derecho absoluto del padre sobre los hijos. Filósofos y médicos defendían o atacaban el aborto, tomando razones de moral, económicas y políticas, tendencia que se ha mantenido a lo largo de los siglos. En todo el mundo, el 38 % de los embarazos son no deseados. El número de abortos inducidos anualmente es de unos 46 millones; 26 millones se llevan a cabo en países donde el aborto es legal y los restantes 20 millones se practican en condiciones de ilegalidad. Metodología: Se realizó un estudio descriptivo con el objetivo de caracterizar a 50 pacientes que acudieron a la consulta de interrupción voluntaria del embarazo para evaluar el conocimiento, las preocupaciones y perspectivas en relación con el procedimiento médico al que se someterían. Resultados: Predominaron las pacientes entre 21 y 25 años, con nivel escolar preuniversitario terminado. El principal motivo para decidir el aborto fue continuar con los estudios académicos. El 60 % de las encuestadas manifestó que volverían a someterse a un aborto en el futuro si las condiciones lo impusieran. Conclusiones: El aborto constituye un tema sensible por su dimensión médica, social, y económica. Profundizar individualmente en las causas y condiciones que motivan a la mujer a tomar la decisión de abortar es esencial en el su manejo.
Exposición a nimotuzumab en una embarazada con glioma de alto grado recurrente
Authors: Navas Evelinda , Acosta Migbelia , Tirado Dulce M. , Saurez Giselle
Published: December 2023

Nimotuzumab es un anticuerpo monoclonal humanizado anti-EGFR, aprobado para pacientes con glioma de nuevodiagnóstico y recurrente. Se desconoce la seguridad de su uso en el embarazo. Se reporta una adolescente de 16 años condiagnóstico de astrocitoma anaplásico en recaída, que recibió nimotuzumab como monoterapia hasta que se comprobó gestación de 13 semanas e interrumpió el tratamiento. En el transcurso de la gestación presentó oligohidramnios leve a las 37 semanas con bienestar fetal conservado. Se produjo parto a término, a las 38 semanas, por cesárea electiva de recién nacido femenino con peso de 2845 g, talla 51 cm, circunferencia cefálica 36 cm y Apgar 9/9. Durante el año de seguimiento posparto, la paciente se mantuvo con control de su enfermedad, sin evidencias de progresión, y la niña evolucionó con un desarrollo pondoestatural normal. Nimotuzumab no parece interferir en el primer trimestre del embarazo, no ocurrieron efectos adversos en este período ni en el producto de la concepción; tampoco se reportan efectos de rebote por lainterrupción del tratamiento.
PERANCANGAN SISTEM INFORMASI PENGAMBILAN CUTI DI CENDANA MART CABANG PEMUDA PEKANBARU BERBASIS WEB
Authors: Yana Sari Risma , Aziz Syarfi , Willyansah  , Mardiati Dina
Published: December 2023

Pembuatan sistem informasi pengambilan cuti di Cendana Mart cabang pemuda Pekanbaru berbasis web bertujuan untuk mengoptimalkan sumber daya teknologi yang dimiliki. Sebelumnya, proses dalam mengambil cuti di Cendana Mart masih belum terkomputerisasi dengan baik sehingga menjadi kurang efisien, maka dari itu penulis bermaksud untuk membantu dengan merancang suatu sistem informasi pengambilan cuti berbasis web menggunakan bahasa pemrograman Hypertext Processor (PHP) dan My Structured Query Language (MySQL). PHP adalah bahasa pemrograman yang digunakan untuk mengembangkan aplikasi web dinamis, sedangkan MySQL adalah sistem pengelolaan basis data yang berbasis pada SQL (Structured Query Language) untuk menyimpan dan mengelola data. Sehingga, hasil dari system yang telah dirancang dapat mempermudah pekerjaan karyawan, admin maupun manajer di Toko Cendana Mart.
Rreth emrave qe perdoren vetëm ne numrin njejes ne gjuhen shqîpe
Authors: Guxho Zhaneta
Published: December 2023

Ashtu si në gjuhë te tjera , edhe në gjuhën shqipe ka një sasi jo të vogël emrash që përdoren vetëm në numrin njëjës. Emrat e këtij tipi

nuk e kanë tërhequr sa duhet vëmendjen e studjuesve të shqipes dhe si rrjedhim në gramatikat e gjuhës shqipe në përgjithësi ose s’janë përmendur fare ose janë trajtuar shkurt. Kështu në gramatikat e Sami Frashërit, Anton Xanonit etj. nuk bëhet fjalë fare për këta emra. Në

Gramatika e re e shqipes. 1944. f. 28. Osman Myderrizi si emra që përdoren vetëm në njëjës, përmend vetëm emrat: e t , uri, kollë .
Material leksikor nga krahinat
Authors: Nushi Jani
Published: December 2023

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Narrative selfies and player–character intimacy in interface games
Authors: Waszkiewicz Agata
Published: December 2023

This paper discusses the use of selfies in narrative-driven interface games, that is games that place the narrative within fictionalized interfaces resembling those of computers or smartphones, as methods of creating intimacy between the characters and the player, while simultaneously maintaining the player’s separateness as a witness of personal stories, rather than their active actor. The article analyses how inter-character and player–character intimacy and emotional distance can be negotiated through the implementation of selfies into the narrative within interface games. The inherent intimacy of such games, which often tell personal stories of people of marginalized identities, is juxtaposed with the constrictions on the player’s agency—both in the overall gameplay and in their inability to take the selfies themselves. Three games are discussed according to three frameworks used to discuss selfies as noted by Gabriel Faimau (2020): a dramaturgic lens (the selfie as self-presentation), a sociosemiotic approach (the selfie as an art of communication), and a dialectical framework (selfie as a social critique).
Fundamento y generalidades de la construcción de modelos estadísticos multinivel en el ámbito de la investigación en salud
Authors: Mera-Mamián Andry Yasmid , Moreno-Montoya José , Rodríguez-Villamizar Laura Andrea , Muñoz Diana Isabel , Segura Ángela María , García Héctor Iván
Published: December 2023

Este trabajo tiene como objetivo presentar una mirada global de la aplicabilidad de los modelos de análisis multinivel en el ámbito de la investigación sanitaria. Ofrece información sobre los fundamentos teóricos, metodológicos y estadísticos y, además, menciona los pasos básicos para la construcción de estos modelos, y da ejemplos de su uso, según la estructura jerárquica de los datos.Cabe resaltar que, antes de utilizar estos modelos, se requiere contar con un soporte teórico sobre la necesidad de uso y una valoración estadística que dé cuenta del porcentaje de varianza explicada por el efecto de agrupación de las observaciones.Los requisitos para llevar a cabo este tipo de análisis dependen de condiciones especiales como el tipo de variables, la cantidad de unidades por nivel o el tipo de estructura jerárquica.Se concluye que los modelos de análisis multinivel son una herramienta útil para lograr la integración de información, dadas la complejidad de las relaciones y las interacciones que determinan la mayoría de las condiciones de salud, incluida la pérdida de independencia entre las unidades de observación.
Germination of pecan seeds changes the microbial community
Authors: Liu Jia , Qiu Sumei , Yang Liping , Yang Can , Xue Tingting , Yuan Yingdan
Published: December 2023

Endophytes are core of the plant-associated microbiome, and seed endophytes are closely related to the plant growth and development. Seed germination is an important part of pecan’s life activities, but the composition and changes of microbes during different germination processes have not yet been revealed in pecan seeds. In order to deeply explore the characteristics of endophytes during the germination process of pecan, high-throughput sequencing was performed on seeds at four different germination stages. Findings of present study was found that the diversity and composition of microorganisms were different in different germination stages, and the microbial richness and diversity were highest in the seed endocarp break stage. It was speculated that the change of endophytes in pecan seeds was related to the germination stage. By evaluating the relationship between microbial communities, the core microbiota Cyanobacteria, Proteobacteria and Actinobacteria (bacterial) and Anthophyta and Ascomycota (fungal) core microbiota were identified in germinating pecan seeds. Finally, biomarkers in different germination processes of pecan seeds were identified by LEfSe analysis, among which Proteobacteria, Gamma proteobacteria and, Cyanobacteria and Ascomycota and Sordariomycetes were most abundant. Thus, this study will help to explore the interaction mechanism between pecan seeds and endophytes in different germination processes, and provide materials for the research and development of pecan seed endophytes.
Selection and evaluation of lactic acid bacteria from chicken feces in Thailand as potential probiotics
Authors: Khurajog Benjamas , Disastra Yuda , Lawwyne Lum Dau , Sirichokchatchawan Wandee , Niyomtham Waree , Yindee Jitrapa , Hampson David John , Prapasarakul Nuvee
Published: December 2023

Background

Lactic acid bacteria (LAB) are widely used as probiotics in poultry production due to their resilience to low pH and high bile salt concentrations, as well as their beneficial effects on growth performance and antagonistic activity against enteric pathogens. However, the efficacy of probiotics depends on strain selection and their ability to colonize the host’s intestine. This study aimed to select, identify, and evaluate LAB strains isolated from chicken feces in Thailand for potential use as probiotics in the chicken industry.

Methods

LAB strains were isolated from 58 pooled fresh fecal samples collected from chicken farms in various regions of Thailand, including commercial and backyard farms. Gram-positive rods or cocci with catalase-negative characteristics from colonies showing a clear zone on MRS agar supplemented with 0.5% CaCO3 were identified using MALDI-TOF mass spectrometry. The LAB isolates were evaluated for acid (pH 2.5 and pH 4.5) and bile salt (0.3% and 0.7%) tolerance. Additionally, their cell surface properties, resistance to phenol, antimicrobial activity, hemolytic activity, and presence of antimicrobial resistance genes were determined.

Results

A total of 91 LAB isolates belonging to the Pediococcus, Ligilactobacillus, Limosilactobacillus, and Lactobacillus genera were obtained from chicken feces samples. Backyard farm feces exhibited a greater LAB diversity compared to commercial chickens. Five strains, including Ligilactobacillus salivarius BF12 and Pediococcus acidilactici BF9, BF14, BYF20, and BYF26, were selected based on their high tolerance to acid, bile salts, and phenol. L. salivarius BF12 and P. acidilactici BF14 demonstrated strong adhesion ability. The five LAB isolates exhibited significant cell-cell interactions (auto-aggregation) and co-aggregation with Salmonella. All five LAB isolates showed varying degrees of antimicrobial activity against Salmonella strains, with P. acidilactici BYF20 displaying the highest activity. None of the LAB isolates exhibited beta-hemolytic activity. Whole genome analysis showed that L. salivarius BF12 contained ermC, tetL, and tetM, whereas P. acidilactici strains BF9 and BF14 carried ermB, lnuA, and tetM.

Conclusion

The selected LAB isolates exhibited basic probiotic characteristics, although some limitations were observed in terms of adhesion ability and the presence of antibiotic resistance genes, requiring further investigation into their genetic location. Future studies will focus on developing a probiotic prototype encapsulation for application in the chicken industry, followed by in vivo evaluations of probiotic efficacy.
El lugar como espacio de denuncia y significación en el poemario Wafpule Mülenymun (Aquí estamos) de Rubén Curricoy
Authors: Rodríguez Droguett Elvira
Published: December 2023

Existe una vinculación entre la poesía mapuche y la política. En esta, encontramos distintos ejes temáticos desarrollados por los autores. En este caso, nos interesa revisar aquella que apunta a la construcción de la identidad a partir de las características del lugar. El objetivo de este artículo es establecer una relación entre la poesía, la ecocrítica y el movimiento autonomista mapuche en la obra del poeta Rubén Curricoy. En esa tríada, la idea de lugar se vuelve fundamental, pues desde ahí surgen estas relaciones. Desde el lugar, se critica el desarrollo industrial que atenta contra la tierra, además, se construye un espacio identitario. La aproximación a la poesía se realizará a partir del concepto de lugar propuesto por L. Buell y las ideas sobre el territorio trabajadas desde el movimiento autonomista mapuche.
Laughing Not to Cry: Resisting Postmodern Melancholia through Humor in Thomas Pynchon’s The Crying of Lot 49
Authors: Zamorano Rodrigo
Published: December 2023

The present article explores the function that humor plays in relation to the portrayal of postmodern culture in Thomas Pynchon’s 1966 novel The Crying of Lot 49. It seeks to expose the understated but persistent melancholy that characterizes Pynchon’s representation of postmodern American culture, and how it relates to the extensive use of humor in the novel. Following the conventions of the detective novel, The Crying of Lot 49 revolves around Oedipa Maas and her quest for a mysterious underground organization called Tristero, a pursuit set in a world that, as the novel unfolds, is shown to be overwhelmingly fragmentary, oversaturated and nonsensical. The possibly destabilizing and threatening effects that this reality has on individuals find their expression in what this analysis characterizes as postmodern melancholia. In the novel, humor is used to simultaneously mask, counterbalance and resist this threat. The diverse forms in which humor is instantiated are analyzed to show how they contribute to the configuration of an implied reader, one that would be able to articulate a form of resistance to postmodern melancholia through a cynical approach to the problems posed by Pynchon’s novel.
A Thing that Cannot Be Put Back Again
Authors: Díaz Klassen Francisco
Published: December 2023

One of the most compelling features of the genre of science fiction is its configuration, “a curious mixture of invented gadgetry and archetypal narrative motifs very obviously derived from folk tale, fairy tale and Scripture, recycling the myths of Creation, Fall, Flood and a Divine Savior, for a secular but still superstitious age” (Lodge, 137). The narrative of myths which sought to explain the present by looking at the origins of the world might have given way to narratives that seek to explain the functioning of the present by predicting alternate futures (or alternate presents or alternate pasts). As Susan Napier has observed, an “intriguing aspect of science fiction [is] its ability to uniquely reflect and comment upon modern culture” (329).
Martyrs on the Mountain
Authors: Su I-Wen
Published: December 2023

This study investigates the origin, transmission, and reception of two hadith with doctrinal significance on the formation of early Sunni identity and memory of the past—the Mountain hadith, in which the Prophet designates each of the first three caliphs as either a saint or a martyr; and the Ten Promised Paradise hadith, which names the first four caliphs and another five or six Companions as the future residents of paradise. The study identifies Qatāda b. Diʿāma and Hilāl b. Yasāf as the earliest transmitters of both hadith. Analysis of their transmission of the Ten Promised Paradise hadith reveals the emergence of a seminal trend among Kufan traditionists, who, by advocating for an all-embracing approach to ʿUthmān, ʿAlī, and the latter’s opponents, allowed various Kufan groups to find common ground, which was also accompanied by the formation of a comprehensive historical narrative on the first fitna.
Back Matter
Authors: Editors
Published: December 2023

Back matter
Review of talugaeš witteš: Ancient Near Eastern Studies Presented to Stefano de Martino on the Occasion of His 65th Birthday
Authors: Beckman Gary
Published: December 2023

talugaeš witteš: Ancient Near Eastern Studies Presented to Stefano de Martino on the Occasion of His 65th Birthday. Edited by MiChele Cammarosano, Elena Devecchi, and Maurizio Viano . Münster: Zaphon, 2020. Pp. xxv + 500, illus. €118.
Review of Between Command and Market: Economic Thought and Practice in Early China
Authors: Glahn Richard von
Published: December 2023

Between Command and Market: Economic Thought and Practice in Early China. Edited by Elisa Levi Sabattini and Christian Schwermann. Leiden: Brill, 2022. Pp. xi + 407. $150.