bluuebunny/crossref_metadata_2025 huggingface dataset:
Biblia Natalis in Russia and in the East: The One-Book Exhibition in the Central Andrey Rublev Museum of Ancient Russian Culture and Art
Authors: Dubrovskaya Dinara V.
Published: February 2020

The Oriental Vernissage opens with a coverage of an exhibition dedicated to a unique item that is interestingly relevant to several research directions reflected in this pilot edition of the OC. Jérôme Nadal’s illustrated Gospel, the rare extant copy of which in Russia is kept in the collection of the Central Andrei Rublev Museum in Moscow, was used by Jesuit missionaries to preach Christianity in China, India and Mexico; and in Russia, his engravings gave rise to a whole array of artistic compositions later found in Russian icon painting in 17th and 18th centuries. In addition to giving the visitors an opportunity to see a very rare book (see Photo 2 (a, b, c)), the exhibition also gave a very telling example of how the visual language of Counter-Reformation Europe was translated—both literally and figuratively—into the languages of the East.
“Afectados por el tacto”: sentidos atribuidos por hombres a las prácticas de prevención del cáncer de próstata
Authors: Almeida Éric Santos , Souzas Raquel , Dos-Santos Edirlei Machado
Published: February 2020

El objetivo del estudio fue identificar y analizar los sentidos atribuidos por hombres a las prácticas relacionadas con la prevención del cáncer de próstata. Se realizó un estudio cualitativo, con entrevistas semiestructuradas, en el que participaron 21 hombres del municipio de Vitória da Conquista, Bahía. El período de recopilación de información fue entre julio y agosto de 2017. El análisis de los datos se basó en los principios de la hermenéutica-dialéctica. Se percibió que las prácticas relacionadas con la prevención del cáncer de próstata se elaboran con escasa información y permeadas por sentidos que remiten al miedo a la enfermedad, asumida como una sentencia a la vida, y a las repercusiones del tacto rectal, asimilado como una violación de la condición masculina. Se constató que las prácticas elaboradas para prevenir el cáncer de próstata reflejan las implicancias de la masculinidad en el cuidado de la salud de los hombres y, sobre todo, que la dureza masculina puede sentirse interpelada a partir de un tacto.
EFEKTIVITAS MODEL PEMBELAJARAN KOOPERATI
Authors: Mayasri Hani Nur
Published: February 2020

Tujuan penelitian ini adalah untuk mengetahui efektivitas model pembelajaran kooperatif tipe CIRC (Cooperative Integrated Reading and Composition) terhadap keterampilan siswa dalam menyelesaikan soal cerita matematika kelas VIII SMP Negeri 7 Salatiga tahun pelajaran 2018/2019. Jenis penelitian ini adalah penelitian eksperimen dengan desain penelitian yang digunakan adalah pretest-posttest control group design. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 7 Salatiga. Pengambilan sampel dilakukan dengan teknik Cluster Random Sampling. Teknik pengumpulan data menggunakan tes berupa soal uraian sebanyak 5 butir soal. Berdasarkan analisis data terhadap skor posttest menggunakan uji-t dengan bantuan software IBM SPSS Statistics 25 diperoleh koefisien Sig. (2-tailed) = 0,000 0,05 yang artinya terdapat perbedaan rata-rata skor posttest antara kelas eksperimen dengan kelas kontrol. Berdasarkan data empiris hasil penelitian diperoleh rata-rata skor posttest kelas eksperimen sebesar 79,26 dan rata-rata skor posttest kelas kontrol sebesar 68,19, sehingga dapat dikatakan bahwa rata-rata skor posttest kelas eksperimen lebih tinggi daripada kelas kontrol. Adapun hasil analisis data terhadap skor N-gain menunjukkan bahwa skor N-gain kelas eksperimen lebih tinggi dibandingkan dengan skor N-gain kelas kontrol. Hal ini menunjukkan bahwa model pembelajaran CIRC lebih efektif terhadap keterampilan menyelesaikan soal cerita matematika dibandingkan dengan metode konvensional.
IMPROVEMENT OF APPROACHES TO TREATMENT OF CHILDREN WITH SUPERFICIAL INFANTILE HEMANGIOMAS OF THE HEAD AND NECK USING HIGH-ENERGY LASERS
Authors: Diomidov Il'ya , Mandra Yuliya , Chernyad'ev Sergey , Gegalina N. , Mandra Ekaterina , Schneider Olga , Shimova Margarita , Dimitrova Yulia , Boldyrev Yuriy
Published: February 2020

Background. Hemangiomas of the skin and mucous membranes, which belong to the group of vascular abnormalities, make up about 50% among other soft tissue tumors in children. Laser coagulation is one of the treatment methods that can provide both a radical removal of superficial hemangiomas and leaving an imperceptible trace.

The goal is to increase the effectiveness of treatment of children with superficial infant hemangiomas of the head and neck by substantiating the differentiated selection of a high-energy laser.

Methodology. A total of 512 children were included in the study. In accordance with the tasks of the study, the total body of material was divided into four parts: evaluation of the long-term results of the treatment of infant hemangiomas; a comparative study of the effectiveness of two laser systems in the treatment of infantile hemangiomas with varying degrees of elevation over the surrounding skin; assessment of the aesthetic efficiency of using laser technologies against the background of the modernization of the cooling method in the treatment of infantile hemangiomas of the face and neck in children; the study of the social effectiveness of the protocol for choosing a method of treatment of infantile hemangiomas of the head and neck in children.

Results. The obtained statistically significant difference in changes on all scales between the two groups mathematically confirmed that the modernized approach makes it possible to obtain higher social effectiveness of the treatment, apparently due to the greater aesthetics of the remaining scars after treatment.

Conclusions. A pronounced difference was found in the response of hemangiomas to various types of lasers, the combination of laser-coagulation with constant water cooling has a greater aesthetic effectiveness than the use of periodic ice applications, the social effectiveness of the approach using the protocol for choosing treatment tactics is higher than with standard approaches.
DENTAL MORBIDITY OF SCHOOL CHILDREN
Authors: Ismagilov Oskar , Shulaev Aleksey , Statseva Elena , Ahmetova Guzel , Berezin konstantin
Published: February 2020

Subject. The results of a retrospective analysis of the prevalence and intensity of major dental diseases in school children are presented.

The goal is to determine the prevalence and intensity of major dental diseases in students aged 7, 12 and 15 years.

Methodology. The study involved 310 children aged 7 to 15 years, studying at school number 165 in Kazan. A clinical study was conducted by dental examination. An outpatient card was set up for each student, in which the results of a dental examination were recorded. Statistical analysis of the results of the study was carried out using a standard statistical software package for Microsoft Office Excel.

Results. The most common dental diseases in children are tooth decay and periodontal disease. The prevalence of dental caries averaged 83.2 %, the intensity — 3.7 ± 0.12 for CPP + CPU. According to the WHO classification, the prevalence of caries of permanent teeth in 12-year-old children is at an average level (75.6 %) with a low level of caries intensity (2.51 ± 0.1). The component K dominates in the structure of the intensity index (1.52 ± 0.1). In 15-year-old schoolchildren, the prevalence of caries is at a high level (87.5 %) with an average level of intensity (4.38 ± 0.1). The “P” component (2.24 ± 0.1) predominates in the structure of the intensity index and the “U” component (0.12 ± 0.1) appears (p <0.05). The prevalence of signs of periodontal disease in primary school children was 3.3 %, in children 12 years old —22.1, 15 years old — 29.0.

Conclusions. The results of the study indicate a low level of dental care, the lack of preventive and therapeutic measures among students of key age groups. The data obtained are aimed at substantiating the main directions of improving dental care for schoolchildren in modern conditions of the healthcare system.
STUDYING OF DISTURBANCES OF THE DENTAL STATUS AT THE YOUNG PEOPLE WHO ARE ENGAGED IN INDEPENDENT TYPES OF EXERCISE STRESSES WITH BURDENING
Authors: Buchneva Valeriya , Oreshaka Oleg , Ganisik Anton
Published: February 2020

Subject. Violations of the dental status in males involved in the gym for 3-4 years.

The goal — is to study the peculiarities of the dental status of young people engaged in physical exercises with weights in the gym, for the further development of a set of preventive and therapeutic measures.

Methodology. The study involved 28 males aged 20 to 29 years, engaged in the gym for 3-4 years with a frequency of visits 3-4 times a week.

The prevalence of the inflammatory process in the gums was determined using PMA indices in modification and KPI. Acid resistance of tooth enamel was evaluated using an enamel resistance test. Palpation and auscultation of the temporomandibular joint, as well as its functional assessment using the diagnostic complex "Lira-100". The following indicators of mixed saliva were determined: secretion rate, viscosity (by the simplified Redinova—Pozdeev method) and Ph. A functional study of the masticatory muscles was performed using surface electromyography.

Results. In 14 examined patients engaged in sports exercises with large weights, increased generalized abrasion of hard tooth tissues was revealed, in 8 — localized.

An index assessment of periodontal tissues confirmed the presence of pathological changes. Dysfunctional disorders in the temporomandibular joints were detected in 20 of 28 amateur athletes (71 %). In young people engaged in bodybuilding, the background activity of the masticatory muscles in a state of functional tension indicates an inconsistent function and asymmetric work of the masticatory muscles.

Conclusions. As a result of the study, in the majority of examined patients non-carious lesions of hard tooth tissues in the form of increased abrasion, more often generalized, and functional disorders of the temporomandibular joints and chewing muscles, in some cases inflammatory changes in periodontal tissues, were revealed.
NOSOGENIC DEPRESSION IN PATIENTS WITH PATHOLOGY OF THE MUCOUS ORAL CAVITY
Authors: Karakov Karen , Vlasova Tatyana , Oganyan Artur , Khachaturyan Araksia , Karakova Svetlana , Harutyunyan Mariam , Amirova Sabina
Published: February 2020

Importance. Despite the improvement of diagnostic methods and the introduction of new technologies in the treatment of pathology of the oral mucosa, it is difficult to achieve stable remission, since 70 % of cases are based on somatic and bodily suffering factors. The article presents data from a comparative analysis of the use of the traditional treatment regimen for patients with pathology of the oral cavity and the inclusion of the latest generation of antipsychotics in the treatment regimen. It was established that, when applied, a tendency towards normalization of psychological and autonomic status was observed. The inclusion of anxiolytics and antioxidants in the complex of general therapy for patients with pathology of the oral mucosa contributed to a more pronounced positive dynamics of achieving and prolonging the phase of remission.

Objectives — to evaluate the effectiveness of introducing drugs of the latest generation of antipsychotics into the traditional treatment regimen for patients with pathology of the oral cavity.

Methodology. Under our supervision, there were 30 patients aged 40 to 60 years with a diagnosis of pathology of the oral mucosa and pathology of the periodontium. All examined were divided into 2 groups: the main (15 people) and control (15 people).

Results. Clinical well-being, manifested in a subjective decrease in pain in the tongue, feelings of rawness, tingling, numbness, awkwardness, in the tongue, was noted already at the 5th visit in 67 % of patients of the main group, while in the control group in 17 % of patients.

Conclusions. The inclusion of anxiolytics and antioxidants in the complex of general therapy for patients with pathology of the oral mucosa contributed to a more pronounced positive dynamics of achieving and prolonging the phase of remission. Our data allow us to implement this treatment regimen in practical healthcare.
PSYCHOLOGICAL CHARACTERISTICS OF DENTAL PATIENTS DETERMINING THEIR COMMITMENT TO COMPLIANCE WITH MEDICAL RECOMMENDATIONS IN DENTISTRY: RELEVANCE FOR PROGNOSTIC AND PREVENTIVE MEDICINE
Authors: Shumilina Elizaveta , Ermaeva Svetlana , Sitkina Evgeniya , Tachalov Vadim
Published: February 2020

Subject. Almost 100 % of people living on Earth have various dental health problems. As a result of studies, it was found that adherence to treatment, individual oral hygiene and attitude to one's health are closely related to the personality characteristics of patients. The goal is to identify the psychological characteristics of the patient that affect their dental behavior and oral health. Methodology. The study involved 99 people aged 19 to 67 years. The following psychodiagnostic techniques were used: Multidimensional Health Locus of Control Scales; Kenneth A. Wallson, Diagnosis of Interpersonal Relationship Test (T. Leary), Leonard-Schmishek Characterological Questionnaire (adult), Individual-Typological Questionnaire Sobchik L.N. (ITO), Questionnaire for self-assessment of the state of the Military Medical Academy. C.M. Kirova (ACC), Personality Questionnaire of the Bekhterev Institute (LOBI). Hygienic and periodontal indices, the treatment need index were determined using CPITN, PMA, Saxer&Muhlemann, Silness&Loe, OHI-S. Results. In the course of the study, after processing the data, statistically significant differences were revealed in the profile of the personality characteristics of patients, depending on which they differently perform doctor's prescriptions. Conclusions. The dentist must take into account the personal characteristics of patients when explaining medical recommendations and selecting preventive or therapeutic programs. The data obtained as a result of the study allow the dentist to predict the patient’s willingness to follow the recommendations for caring for the oral cavity and maintaining their health, as well as to build an individual treatment plan that takes into account the patient’s characteristics and his level of compliance. An individualized approach to the patient, we assume, will increase the level of compliance, which in turn will ensure a reduction in dental diseases in patients.
THE EFFECT OF LOW-INTENSITY LASER RADIATION ON THE EFFECTIVENESS OF COMPLEX TREATMENT OF GENERALIZED PERIODONTITIS
Authors: Garazha Sergey , Grishilova Elena , Nekrasova Elizaveta , Garazha Irina , Hubaev Tamerlan , Ilina Ekaterina , Hubaeva Fatima
Published: February 2020

Subject. Periodontitis is an inflammatory and destructive process in periodontal tissues, the main etiological factor of which, according to modern concepts, is the microbial invasion of the gingival groove by qualitatively and quantitatively modified microorganisms of cervical plaque. Based on the etiopathogenetic bacterial-vascular mechanisms of the occurrence and progression of inflammatory and destructive periodontal diseases, the use of low-energy (low-intensity) laser exposure was included in all the algorithms for the comprehensive treatment of periodontitis that we studied.

Objective: to study the effect of low-intensity laser radiation in combination with local non-steroidal anti-inflammatory drugs on the effectiveness of complex treatment of periodontitis.

Methodology. The study involved 120 patients (60 men and 60 women), equally divided into four groups depending on the treatment performed. A randomized controlled trial with discrete longitudinal open observation was conducted.

The therapy included the implementation of professional oral hygiene using an ultrasound apparatus, sandblasting, polishing all surfaces of the teeth, a hygiene lesson, recommendations. The methodology of pharmacological treatment was to perform the application of the anti-inflammatory drugs Oralsept and Arkoxia to the periodontal area for 15 minutes with a course of 10 procedures. In the second and fourth groups, low-energy laser exposure was performed using the Optodan apparatus in the second mode for 15 minutes. The course of therapy was 10 procedures.

The clinical study was conducted according to generally accepted principles with mandatory x-ray control and an index assessment of the periodontal condition.

Results. After a six-month observation period, in the first and third groups, there was a deterioration in both index and hemodynamic digital data, and in the second and fourth indicators remained at a fairly positive level, indicating the effectiveness of the therapy.

Conclusions. The use of NLV increases the effectiveness of local exposure to non-steroidal anti-inflammatory drugs "Arkoxia" and "Oralsept" by 16 and 19 % respectively. The positive effect of NLV is maintained throughout the observation period.
EVALUATION OF THE STATE OF PARODONTAL TISSUES IN INDUSTRIAL WORKERS
Authors: Shulaev Aleksey , Berezin Veniamin , Statseva Elena , Makarova Natalja , Vasilieva Guzal'
Published: February 2020

Subject. The results of a clinical examination of workers of the special economic zone "Alabuga" of the Republic of Tatarstan and JSC "Chemical Plant named after L.Ya. Karpova ”(Mendeleevsk), including a comparative analysis of data on the prevalence of inflammatory periodontal diseases.

The goal is a comparative assessment of the prevalence of inflammatory periodontal diseases among workers in the Alabuga Special Economic Zone of the Republic of Tatarstan and JSC "Chemical Plant named after L.Ya. Karpova"(Mendeleevsk).

Methodology. Dental status was evaluated using WHO methods and criteria. The clinical study was conducted through a comprehensive dental examination of 370 employees of the special economic zone “Alabuga” of the Republic of Tatarstan (the main group) and 297 employees of JSC “Chemical Plant named after L.Ya. Karpova ”(Mendeleevsk) (comparison group).

Results. According to the results of our clinical diagnostic examination of the oral cavity in the main group and the comparison group of workers of industrial enterprises, certain differences were revealed. In the main group, an intact periodontium without signs and with signs of inflammatory periodontal lesions was diagnosed in 39.2 and 60.8 % of cases, in the comparison group — in 53.2 and 46.8 %, respectively. An analysis of the hygiene index in the main group showed that 62.4 % of the subjects showed poor oral hygiene, 19.7 % had poor hygiene, and in the comparison group 32.3 and 3.03 %, respectively.

Conclusions. Thus, the data obtained justify the need and relevance of the proposal and the introduction of organizational principles for providing industrial workers with high-quality dental care. It is necessary to reform the dental service in order to increase priority, quality and preventive orientation when servicing workers directly at the factory.
TAX COMPLIANCE WITH TAXPAYER AWARENESS AS AN INTERVENING VARIABLE
Authors: Idrus Arifin , Lalo Annas , Tenreng Mariana , Badruddin Syamsiah
Published: February 2020

Purpose of the study: This research explores the role of taxpayer awareness as an intervening variable in analyzing the effect of tax penalties and tax audits on taxpayer compliance.

Methodology: The Research to use a purposive sampling method with the type of sample selection based on consideration the judgment sampling.

Main Findings: The results of the SmartPLS Version 3.0 test provide evidence that tax penalties and tax audits carried out by professional auditors proved to be able to increase taxpayer compliance in paying their taxes in a timely manner.

Applications of this study: The population of this study is individual taxpayers who carry out free work recorded at Tax Offices (KPP) Pratama Makassar (KPP Pratama Makassar Utara, KPP Pratama Selatan, and KPP Pratama Makassar Barat). whose status is still active, until January 2017 there were 234,104 effective taxpayers.

Novelty/Originality of this study: The nationalism of the people as citizens and as high taxpayers creates a high sense of tax awareness that has an impact on their high compliance in paying taxes.
Komendantka Oddziału Kuriersko-Wywiadowczego I Brygady Legionów. Aleksandra Szczerbińska i towarzyszki broni
Authors: Sikorska-Kowalska Marta
Published: February 2020

Artykuł omawia powstanie i działalność Żeńskiego Oddziału Kuriersko-Wywiadowczego, na czele którego stała Aleksandra Szczerbińska. Po wycofaniu się z Kielc Oddziałów I Brygady 30 października 1914 r. Aleksandra Szczerbińska „Ola” objęła komendę nad oddziałem kobiecym z rąk Kazimierza Sawickiego. Dowodzony przez nią Żeński Oddział Wywiadowczy jako część Oddziału Wywiadowczego podlegał najpierw I Pułkowi Piechoty Legionów, a następnie I Brygadzie. W oddziale tym służyło 46 kobiet. Były to członkinie Związku i Drużyn Strzeleckich, które miały kilkuletnie wykształcenie wojskowe. W oddziale kuriersko-wywiadowczym służbę pełniły również kobiety należące do politycznych organizacji niepodległościowych. Postawa, odwaga, determinacja wywiadowczyń z Żeńskiego Oddziału Kuriersko-Wywiadowczego wielokrotnie znajdowała uznanie w opiniach Józefa Piłsudskiego.
MULHERES PORTUGUESAS NO PARÁ: números, perfis, redes sociais e visibilidade (1834-1930)
Authors: CANCELA CRISTINA DONZA
Published: February 2020

O artigo analisa a imigração de mulheres portuguesas para o estado do Pará entre a primeira metade do século XIX einício do XX, observando o fluxo dessa migração, a reemigração, o perfil relativo à idade, estado civil e origem, bem como as redes sociais acionadas por aquelas que migravam. O trabalho evidencia o aumento da presença feminina no fluxo migratório nas primeiras três décadas do século XX, marcado por mulheres jovens e solteiras vindas do norte português, trabalhando como criadas, por vezes, seguindo os passos dados por um parente. Para a realização do trabalho foram levantados os registros de passaporte e as habilitações consulares.
Palavras-chave: Imigração Portuguesa. Mulheres. Pará.
 
PORTUGUESE WOMEN IN PARÁ: numbers, profiles, social networks and visibility(1834-1930)
Abstract: The article analyzes the immigration of Portuguese women to state of Pará between the first half of nineteenthcentury and the beginning of the twentieth century observing the flowof this migration, the reemigration, the ageprofile, marital status and origin, as well as the social networks. The work evidences the increase in the female presence in the migratory flow in the first three decades of the twentiethcentury, marked by young and single women from the Portuguese North, working as maidsfollowing the steps given by a relative. The documents used for the analysis were Passport records and the Consular Habilitations.
Keywords: Portuguese immigration. Women. Pará.
MUJERES PORTUGUESAS EN PARÁ:números, perfiles, redes sociales y visibilidad (1834-1930)
Resumen: El artículo analiza la inmigración de mujeres portuguesas al estado de Pará entre la primera mitad del siglo XIX y principios del XX, y observa el flujo de esta migración, la reemigración, el perfil de edad, estado civil y origen, así como las redes sociales provocadas por quienes migraron. El trabajo muestra el aumento de la presencia femenina en el flujo migratorio en las primeras tres décadas del siglo XX, marcado por mujeres jóvenes y solteras que vinieron del norte de Portugal y trabajaban como sirvientas, a veces, siguiendo los pasos dados por un pariente. Para llevar a cabo el trabajo, se encuestaron los registros de pasaportes y las calificaciones consulares.
Palabras clave: Inmigración Portuguesa. Mujeres. Pará.
INFORMAÇÕES EDITORIAIS
Authors: Cavalcante Anissa Ayala
Published: February 2020

Quantitativos de textos publicados neste volume (v. 17, n. 29)
BIOMARKERS OF ANGIOGENESIS AND ENDOTHELIAL DYSFUNCTION IN CHILDREN AND ADOLESCENTS WITH CHRONIC VIRAL HEPATITIS
Authors: Batyrova A. S. , Vasilieva E. M. , Bakanov M. I. , Surkov A. N.
Published: February 2020

At some works, it has been shown there are signs of damage and endothelium dysfunction in patients with chronic viral hepatitis (CVH) and liver cirrhosis of viral etiology the severity of these conditions depends on the severity of the pathological process. Evaluation of the role of angiogenic factors and endothelial dysfunction in persistent of CVH in children and adolescents. 35 patients were examined: of which 11 with chronic hepatitis B (CHB) and 24 with chronic hepatitis C (CHC). The reference group consisted of 120 practically healthy persons of the corresponding age and sex. VEGF-A, angiotensin (ANG), soluble receptors of VEGF-A (sVEGF-R1 и sVEGF-R2) and trombomodulin (TM) have been investigated in serum by enzyme immunoassay using special kits (BCM Diagnostics, USA). Other endothelial dysfunction markers as von Willebrand factor (vWf) was determined in blood plasma by immunoturbidimetry (Siemens, Germany), plasminogen (PLG) was investigated due to extended coagulation. In children with CVH, regardless of etiology, the concentration of VEGF-A was significantly lower, and sVEGF-R2, sVEGF-R1 and TM was higher than in children without liver disease (p <0.001, p <0.05, p <0.01, p <0.001, respectively). The concentration of TM and the level of PLG activity in patients with CHC were slightly higher than in CHB. Decreased level of VEGF-A and increased expression of its soluble receptors indicate enhanced inhibition of angiogenesis in CVH, which may indicate the pathogenetic role of this phenomenon in the development of liver damage in CHC.
IMPROVING THE QUALITY OF HEMATOLOGICAL STUDIES USING SIGMAMETRY
Authors: Petrova O. V. , Shabanova G. R. , Murygina O. I. , Panova E. V. , Nikulina D. M.
Published: February 2020

The purpose - evaluated the quality of the implementation of hematology studies using sigmametry. Studies were perfomed at the Federal state budgetary establishment “Federal center cardiovascular surgery”. The data were collected in the period for 2017 y. The following hematology parameters were monitored daily: white cells, red blood cell, platelet, hemoglobin. For conducting laboratory quality control we used certified three-level (Level 1 (low) , Level 2 (normal)and Level 3 (High)) control material “CBC-XE Hematology control” (“R and D Systems”, USA). The study of blood hematology parameters was carried out on an automatic hematology analyzer “Sysmex XT- 2000i” and “Sysmex XT- 1800i” (“Sysmex Corporation”, Japan). Sigmametry values were calculated the CV (coefficient of variation), the systematic error (Bias) and the total allowable analytical error (TE max). On the analyzer «Sysmex XT- 2000i» sigma values for platelet were between 3 and 4. For white blood cells, red blood cells, hemoglobin the value of the sigma was greater than 4. On the analyzer «Sysmex XT- 1800i» for platelet, white blood cells, red blood cells, hemoglobin the value of the sigma was greater than 4. Based on the results obtained, we drew conclusions on the choice of control material and the frequency of the internal laboratory quality control. The introduction of sigmametry in the daily activities of clinic laboratory will improve the quality of the determination of platelet, which requires further observation.
TECHNIQUES OF MODIFYING LIPID ANTIGENS FOR SYNTHESIS OF DIAGNOSTIC AND THERPAEUTIC PREPARATIONS IN RHEUMATOLOGY
Authors: Gontar I. P. , Emelyanova Oiga Ivanovna , Rusanova O. A. , Zborovskay I. A. , Emelyanov N. I.
Published: February 2020

The objective of the study is to enhance sorption capacity of diagnostic agents by using cardiolipin antigens for antiphospholipid syndrome in patients with systemic lupus erythematosus (SLE). A technique of emulsion polimerization was used. Having integrated antigen nanoobjects we developed immobilized magnetocontrollable antigen nanosystems and put them to an evaluation test. The nanosystems are polyacrylamide granules with a built in antigen. To obtain stable immobilized multi-use biopharmaceuticals with targeted properties (shape, particle diameter, pore size, density) we used a modified version of emulsion polymerization method using polyacrylamide carrier gel. This method permitted a greater sorptive capacity, preserving the antigen in maximum native state, and opened up the possibility of controllable modification of nanoobjects. Cardiolipin was used as the antigen in question. Following the method described above we performed sorption of anticardiolipin antibodies from blood plasma of SLE patients who showed clinical presentations of antiphospholipid syndrome. All SLE patoents with signs of antiphospholipid syndrome showed reliably higher levels of cardiolipin antibodies compared with SLE patients without antiphospholipid syndrome signs; the antibody level was 0.365 ± 0.026 and 0.075 ± 0.003 on average, correspondingly (p < 0.001). Blood serum from 10 apparently healthy individuals served as control. The level of cardiolipin antibodies was determined before and after sorption by indirect solid phase immunoenzyme method. In the eluate we estimated total protein by Lowry method. In vitro testing showed that the obtained antigen nanosystems based on immobilized cardiolipin could effectively remove cardiolipin antibodies from whole blood of SLE patients with clinical presentations of APS to achieve the values of healthy individuals (before sorption cardiolipin antibodies 0.328 ± 0.0289; after sorption 0.059 ± 0.0170; p<0,001; sorption capacity 8.00 ± 0.390 mg/ml). The method of emulsion polymerization with consideration to hydrophobic and hydrophilic properties of lipid molecules permits obtaining and modifying biomolecules with certain properties, in a controlled fashion.
APPLICATION OF ALPHA-FETOPROTEIN AND OSTEOPONTIN COMBINATION FOR EARLY DIAGNOSIS OF HEPATOCELLULAR CARCINOMA ASSOCIATED WITH HEPATITIS C
Authors: Malov Sergey Igorevich , Malov I. V. , Dvornichenko V. V. , Rasulov R. I. , Kuvshinov A. G. , Marche P. N. , Decaens T. , Macek-Jilkova Z. , Yushchuk N. D.
Published: February 2020

Liver cirrhosis in the outcome of hepatitis C is the leading cause of hepatocellular carcinoma (HCC) in the world. Early diagnosis and timely treatment of HCC are important for reducing mortality and increasing life expectancy of patients with hepatocellular carcinoma. To assess the risk of HCC, the definition of alpha-fetoprotein (AFP) in the blood is most widely used, but low sensitivity limits its diagnostic value. In 2012, a new HCC biomarker - osteopontin (OPN), which is a secreted phosphoprotein that has a high affinity for integrins was proposed. The level of acute renal failure begins to rise in the early stages of malignancy, before the period of HCC detection by imaging methods, and has significantly better sensitivity than AFP. The purpose of this study is to evaluate the diagnostic efficacy of the combined determination of alpha-fetoprotein and osteopontin in prospective monitoring of patients with chronic hepatitis C in the advanced phase of liver fibrosis. Monitoring of 588 patients with hepatitis C was carried out from February 2013 to February 2019. HCC was detected in 55 of them (2.6% per year). The combination of 2 biomarkers showed better diagnostic efficacy than alpha-fetoprotein and osteopontin separately: AUC 0.85 (95% CI 0.80-0.90) versus AUC 0.63 (95% CI 0.57-0, 70) and AUC 0.82 (95% CI 0.77-0.88), respectively. This combination showed a sensitivity of 85.5% and made it possible to diagnose HCC with a prognostic level of a positive result of 72.3% at 19,4±0,8 weeks before the diagnosis was confirmed by instrumental imaging methods (ultrasound, MRI, CT). In the combined variant, ARF made the greatest contribution to the increase in diagnostic efficacy (AUC). At an early and very early stage of HCC development, isolated HCC elevations were found in only 5.4% of patients. Conclusion: the combined use of alpha-fetoprotein and osteopontin as a diagnostic panel can be recommended for monitoring patients with liver cirrhosis in the outcome of hepatitis C and predicting HCC at an early stage of development.
EXPANSION OF OPPORTUNITIES IN DIAGNOSTICS OF BACTEREMIA AND SEPSIS IN CHILDREN OF A MULTI-PROFILE HOSPITAL
Authors: Boronina Lyubov Grigorievna , Samatova E. V. , Prutkin M. E.
Published: February 2020

Primarily in the study of bacteremia, coagulase-negative staphylococci and representatives of the order Enterobacterales were found. To establish the etiological role of coagulase-negative staphylococcus in making a diagnosis of sepsis in each particular case, it is necessary to consider the condition and age of the child, as well as indicators of markers of systemic inflammation. In 1/3 cases of coagulase-negative staphylococcus indicate colonization of the catheter. Staphylococcus aureus in bacteremia and sepsis - 6.5%, Haemophilus influenzae - 0.6%, Esherichia coli - 7.8%, Streptococcus agalactiae - 2%. For the diagnosis of sepsis, it is necessary to conduct repeated (at least two times) blood culture studies using high-quality nutrient media containing all the necessary growth factors, followed by a mandatory determination of the susceptibility of the isolated strains of microorganisms to antimicrobial agents. Bacteremia as a whole in children of a multidisciplinary hospital amounted to 5.8%. In premature babies, bacteremia was detected in 4.4% of cases, of which sepsis was confirmed in 41,2%.
ANTIMICROBIAL RESISTANCE AND CLINICAL SIGNIFICANT RESISTANCE MECHANISMS OF SALMONELLA ISOLATED IN 2014-2018 IN ST.PETERSBURG, RUSSIA
Authors: Egorova Svetlana A. , Kaftyreva Lidiya A. , Suzhaeva Lyudmila V. , Zabrovskaia Anna V. , Voitenkova Elena V. , Matveeva Zoya N. , Ostankova Yulia V. , Likhachev I. V. , Satosova N. V. , Kitsbabashvili R. V. , Smirnova E. V. , Semchenkova L. I. , Bystraya T. E. , Sokol’nik S. E. , Utkina N. P. , Sikhando L. Y.
Published: February 2020

The article presents the results of antimicrobial resistance monitoring of Salmonella isolated from children and adults with diarrhea in St. Petersburg in 2014-2018. In 746 isolates of 42 serovars more than 90,0% belonged to three: S. enteritidis (79,6%), S. typhimurium (6,8%) and S. infantis (3,8%). The antimicrobial susceptibility testing (according the EUCAST) to 7 classes of antimicrobials revealed the resistance in 78,6% of Salmonella. Low-level quinolone resistance (MIC of ciprofloxacin 0,12-0,5 mg/l) was detected in 63,3% isolates (S. enteritidis -71,0%, S. typhimurium - 15,7%, S. infantis - 89,3%) and was due to five kinds of single nucleotide substitutions in gyrA: Asp87Tyr - 36,1% of studied isolates (only S. infantis); Ser83Phe - 22,2% (only S. enteritidis); Asp87Asn - 19,4% (S. enteritidis, S. typhimurium, S. hadar, S. newport); Ser83Tyr -11,1% (S. enteritidis and S. infantis) and Asp87Gly - 8,3% (only S. enteritidis). Only in one S. kentucky isolate with high-level fluoroquinolone resistance (MIC of ciprofloxacin > 8,0 mg/l) two substitutions (Ser83Phe and Asp87Asn) were detected. Two Salmonella isolates (S. typhimurium and S. corvallis) had plasmid-mediated quinolone resistance (qnrS). Extended-spectrum cephalosporin resistance was found in 6 Salmonella serovars (1,6%). The bla-genes were detected: of genetic group CTX-M1 - in 10 isolates (serovars S. typhimurium, S. enteritidis, S. abony, S. coeln and S. virchow), CTX-M2 - in 2 S. typhimurium isolates, CTX-M9 - in three S. enteritidis isolates. In one S. typhimurium CTX-M1 and CTX-M2 were detected. The gene of CMY-2 (molecular class C cephalosporinase) was revealed in two isolates (S. newport and S. enteritidis). Our study showed that Salmonella (the main bacterial pathogen of acute diarrhea in children and adults) isolated in Saint-Petersburg had antimicrobial resistance to drugs of choice for salmonellosis treatment.
HEPATITIS B VIRUS IDENTIFICATION IN A BLOOD PLASMA AT A LOW VIRAL LOAD
Authors: Ostankova Yu. V. , Semenov A. V. , Totolian Areg A.
Published: February 2020

To analyze the method for detecting HBV DNA in peripheral blood at low viral load and evaluate its significance in identifying HBsAg-negative viral hepatitis B. In this work, samples of blood and liver tissue biopsy material were used from 128 patients living in the Russian Federation and the Republic of Uzbekistan without CHB and with CHB confirmed detection of circle covalently closed HBV DNA in hepatocytes. Plasma viral load was measured using the «AmpliSens® HBV-Monitor-FL» kit. HBV at low viral load was detected by nested PCR. Analytical sensitivity was checked by step dilution. According to our method, at the first stage, an asymmetric PCR is carried out using extended oligonucleotide primers with different melting points, complementary to the hepatitis B different genotypes genomes greatest similarity region. To increase the sensitivity, a second PCR is performed using the first reaction amplification product and internal primers. The sensitivity of the method for DNA extraction from 100 μl of plasma was 5 IU / ml, specificity 100%. Since, in spite of the HBV genotypes characteristic geographical distribution, the detection of “alien” genovariants for certain territories is becoming more frequent, we tested the method in geographically remote but active international relations with the Russian Federation regions with a high frequency of hepatotropic viruses. The developed method for detecting HBV DNA in blood plasma at low viral load based on PCR technology allows the various HBV gene variants identification and genotyping, both characteristic and rare in the Russian Federation, circulating in other world regions . The method can be used to detect HBV in risk groups, in a population, as well as when screening blood donors in order to ensure the blood transfusions safety.
Un camino lleno de contradicciones
Authors: Flórez Vera Jesús Alberto
Published: February 2020

Este artículo muestra la vida de san Juan Bautista de La Salle, fundador de la Congregación de los Hermanos de las Escuelas Cristianas, a través de una narración creativa e histórica que surgió del conocimiento sobre su obra. Este relato imaginario, con sugestivos diálogos y situaciones, busca aproximar al lector al itinerario evangélico del santo francés
El diálogo interreligioso desde las narrativas religiosas
Authors: Siciliani Barraza José María
Published: February 2020

El artículo estudia el sentido de los relatos religiosos según la perspectiva del antropólogo Lluís Duch. Para lograr ese objetivo, explora dos conceptos previos: lenguaje y religión. Una vez establecida la capacidad simbólica de ambas nociones, gracias a la cual el hombre hace presente lo ausente, el artículo analiza algunos de los rasgos del relato religioso.
A la luz de esas consideraciones, se muestra el potencial evocador de este relato y, al mismo tiempo, sus límites, puesto que son una mediación que jamás puede remplazar o sustituir al Misterio hacia el que apuntan. El artículo postula que el reconocimiento de esos límites es la condición básica para el diálogo entre las religiones
Influência do teor de glúten na qualidade de biscoitos elaborados com farinha de triticale
Authors: Watanabe Erika , Arruda Klever Marcio Antunes , Kitzberger Cintia Sorane Good , Scholz Maria Brigida dos Santos , Coelho Alexandre Rodrigo
Published: February 2020

Triticale (x Triticosecale Wittmack) é um cereal com potencial uso industrial, desenvolvido como alternativa ao trigo. Apesar de combinar o rendimento e qualidade do trigo com a adaptabilidade ambiental e resistência às doenças do centeio, a baixa qualidade de glúten da farinha limita seu uso na indústria alimentícia. Nesse contexto, o presente estudo teve como objetivo avaliar a influência do conteúdo de glúten na qualidade de biscoitos confeccionados com farinha de triticale. Devido ao baixo teor de glúten (TLD 1202, não detectado e BRS Minotauro 11,35%), as farinhas de triticale tiveram tempo de desenvolvimento reduzido (0,50 para TLD 1202 e BRS Minotauro 1,10 minutos), baixa estabilidade da massa (0,40 para TLD 1202 e BRS Minotauro 3,00 minutos) e capacidade reduzida de retenção de ácido láctico (64,14% para TLD 1202 e 78,20% para BRS Minoauro). Contudo, essas farinhas influenciaram positivamente a largura, fator de expansão e textura instrumental dos biscoitos produzidos. Com índices de aceitação acima de 81%, biscoitos com farinha de triticale superaram os biscoitos elaborados com farinha de trigo em todos os atributos sensoriais avaliados.  As farinhas de triticale mostraram propriedades adequadas para fabricar de biscoitos de alta qualidade, mantendo as características do produto, independentemente do conteúdo de glúten.
The Correlation between Physical Environmental Factors and Fatigue of The Workers at Ship Repair Workshop
Authors: Pratiwi Aulia Nur
Published: February 2020

Introduction: Fatigue is a body protection mechanism that prevents further detriments and can be recovered after having a sufficient amount of rest. The fatigue undergone by workers is one of the causes of occupational accidents. Fatigue can be triggered by several factors, such as physical environments, for instance, temperature and noise. This research aims to analyze the relationships between the temperature as well as the noise and the work fatigue of the workers at the area of ship repair workshop at PT. X Surabaya. Methods: This research is descriptive observational research that employs the cross-sectional design. The sample of this research, the total population, consists of 32 people. The data is obtained through the temperature measurement by utilizing hygro-thermometer, the noise intensity measurement by utilizing the sound level meter, and the levels of work fatigue measurement by utilizing reaction timer. Those measurements are completed in two different locations, namely the office and the workshop. The strength of the relationships among variables is scrutinized by applying the spearman correlation test by studying the correlation coefficient value. Results: Show that 14 people (43.8%) do not suffer from any fatigue, 15 people (46.9%) suffer from mild fatigue, 2 people (6.2%) suffer from moderate fatigue, and 1 person (3.1%) suffers from severe fatigue. The fatigue is mostly undergone by the workers exposed to the overheat temperature, that is as many as 18 people (56.2%) and by those who are exposed to noise, which are 15 people (46.9%). Conclusion: There is a moderate relationship between the temperature and the fatigue (p=0.519). Meanwhile, the noise (p=0.688) has a strong relationshipship with the fatigue undergone by the workers at the area of ship repair workshop at PT. X Surabaya. Keywords: noise, ship reparation, temperature, work fatigue
The Description of Internal and External Factors of Fatigue at Sidoarjo Steel Smelting Company
Authors: Syahfudin Andy Juniar
Published: February 2020

Introduction: Work fatigue or fatigue is a kind of body prevention from further damages. The fatigue experienced by a worker resulted in a decrease in work performance and lack of body endurance during the work. The workers of steel smelting companies are one of the examples of workers who potentially experience work fatigue. This research aims to ascertain both the internal and external factors of work fatigue experienced by the workers at Sidoarjo steel smelting company. Methods: This research was conducted at Sidoarjo steel smelting company in May 2018 with a population of 30 people. The internal factors in this research are the age, years of service, and nutritional status of the workers. Meanwhile, the external factors are the physical workload, work climate, and noise. This research is descriptive research with observation as the data collection method and is cross-sectional research design. The sample is calculated by applying the total population sampling technique. The data is presented descriptively in the form of frequency, percentage, and cross-tabulation among variables distributions. Result: It is revealed that the majority of the workers, as many as 17 people, undergo mild work fatigue (56.7%). The results of the cross-tabulation show that moderate and severe fatigues are mostly experienced by the workers with these criteria: younger, shorter years of service, obese, fair physical workload, and work climate and noise that exceed the Threshold Limit Value (TLV). Conclusion: It is affirmed that both the internal and external factors are related to work fatigue. Keywords: external factors, internal factors, steel smelting, work fatigue
Factors Related to the Complaints of Musculoskeletal Disorders of Shelving Staff
Authors: Treesyanova Yovian
Published: February 2020

Introduction: Every worker is exposed to the risk of occupational accidents or occupational diseases when working. Awkward working postures are the postures that cause body parts to detach from its natural postures that can result in the complaints of musculoskeletal disorders (MSDs). This research intends to analyze the factors related to the complaints of MSDs suffered by the shelving staff in the library and reading room in Universitas Airlangga Surabaya. Methods: This research is observational research that applies a cross-sectional design. The sample of this research consists of 27 people chosen by the total population method. The data regarding the individual characteristics and the complaints of MSDs are obtained through interview and filling out a questionnaire that has been standardized. The data on working postures are analyzed by referring to the Rapid Entire Body Assessment (REBA) method, while the data on the complaints of MSDs are scrutinized by implementing the Nordic Body Map (NBM) method. Results: Reveal that most of the shelving staff experience very high-risk level of MSDs (40.7%). Other than that, it is noticed that the working postures consist of squatting (high-risk level), bowing (high-risk level), standing (moderate-risk level), standing with arms stretching (very high-risk level), and standing with arms stretching while tiptoeing (very high-risk level). The collected data is analyzed by using the Spearman correlation test. Conclusion: It can be stated that the strongest factor causing the occurrence of MSDs is the years of service (r=0.803) with a positive relationship, which means that the longer the years of service is, the higher the risk to experience MSDs is. Keywords: complaints of musculoskeletal disorders, individual factors, shelving staff
Effects of sidestream tobacco smoke on P53 expressions in Rattus novergicus tongue epithelial mucosa
Authors: Angriany Dian , Ernawati Diah Savitri , Parmadiati Adiastuti Endah , Hendarti Hening Tuti , Zain Rosnah Binti
Published: February 2020

Background: Smoking, both active and passive, has been widely recognised as toxic to the human body, since it induces several forms of cancer, including that affecting the oral cavity. Benzopyrene, the carcinogen contained in tobacco smoke, can even lead tocarcinogenesis which potentially affects the regulation of cell apoptosis in both active and passive smokers. Purpose: This study aims to investigate the carcinogenic effects of cigarette smoke on apoptosis of rat tongue mucosae through p53 expression. To determine the risk of malignant transformation through tumor suppressor genes in the apoptotic pathway. Methods: Rattus norvegicus subjects were divided into four groups, namely Treatment Group 1 exposed to sidestream cigarette smoke for four weeks (P1), Treatment Group 2 exposed to sidestream cigarette smoke for eight weeks (P2), Control Group not exposed to sidestream cigarette smoke for four weeks (K2), and Control Group (K) not exposed to sidestream cigarette smoke for eight weeks (K2). The exposure process was conducted using a smoking pump and alternating exposure. Four micron-thick sections of formalin were subsequently fixed together with paraffin embedded biopsy material from tongue mucosa of Rattus norvegicus. The tissue sections from the treatment groups were then analyzed immunohistochemically to compare the expressions of p53 and Bcl-2 proteins with those of the control groups. Results: The T-test results indicated statistically significant differences in the expressions of p53 between the 4-week control group (K1) and the 4-week treatment group (P1) (p=0.01, p<0.05) as well as between the 8-week control group (K2) and the 8-week treatment group (P2) (p=0.03, p<0.05). Conclusion: Exposure to cigarette smoke can induce changes in tumor suppressor genes and also affect the regulation of cell apoptosis, thus changing cell structure and leading to malignancy.