bluuebunny/crossref_metadata_2025 huggingface dataset:
Radical neuroconstructivism: a framework to combine the how and what of teaching and learning?
Authors: Tokuhama-Espinosa Tracey , Borja Cynthia
Published: August 2023

Recent advances in pedagogical research have called attention to the dynamic nature of the teaching and learning process in which the actors mutually influence one another. The understanding of how this works in the brain—the specialized neural networks related to this process—is often limited to neuroscientists but are slowly becoming available to other learning scientists, including teachers. A transdisciplinary approach combining the best information about observable teaching-learning processes from education with newer information from the neurosciences may aid in resolving fundamental questions in the learning process. Teachers’ professional formation and development is often structured in segmented topical ways (e.g., pedagogy, evaluation, planning, classroom management, social–emotional learning), to identify important content knowledge (e.g., art, reading, mathematics, STEM), or to appreciate life skills (e.g., collaboration, critical thinking, social–emotional learning). While important, knowledge about the brain, the organ responsible for learning, is typically absent from teacher education. This paper reexamines the evidence from neuroconstructivism and the hierarchy of learning trajectories and combines it with evidence from psychology and the ways humans interact during the teaching-learning process to suggest radical neuroconstructivism as a framework within which to organize teachers’ professional development. The radical neuroconstructivism framework may contribute to making the content knowledge of teachers’ continual professional development more visible.
Comparative analysis of torque-adding wind energy conversion systems with a counter-rotating vs. conventional electric generator
Authors: Saulescu Radu , Jaliu Codruta , Neagoe Mircea , Ciobanu Daniela , Cretescu Nadia
Published: August 2023

The paper presents a comparative analysis on the steady-state behavior of two counter-rotating wind turbines with same components, where the generator can operate as a counter-rotating (with both a mobile rotor and stator—Case a) vs. conventional (with a fixed stator—Case b) electric machine. These wind energy conversion systems (WECSs) also have two coaxial counter-rotating wind rotors and a one-degree-of-freedom (1-DOF) planetary speed increaser with two inputs and one or two outputs for compatibility with the considered generator. The paper aims at highlighting the efficiency and energy performances of WECSs with a counter-rotating vs. conventional generator by investigating three functional scenarios (A, B, and C) of the two WECS cases (a and b) under the assumption of identical or different counter-rotating wind rotors. A generalized kinetostatic modeling algorithm is first proposed, starting from the general case of WECS with a counter-rotating generator, which allows the establishment of analytical relationships corresponding to speeds and torques at input and output shafts. Numerical simulations of the obtained closed-form model in each scenario highlighted the influence of the constructive parameters on WECS performances, as well as the energetic superiority of WECS, with a counter-rotating generator (Case a) vs. conventional generator (Case b): higher efficiency by 1.2% and more output power by 1% (Scenario A) to 5.5% (Scenario C).
Single-cell RNA sequencing reveals the transcriptomic characteristics of peripheral blood mononuclear cells in hepatitis B vaccine non-responders
Authors: Zhao Meie , Wang Chunxia , Li Peiqiang , Sun Tao , Wang Jing , Zhang Shasha , Ma Qinglong , Ma Fengdie , Shi Wenjing , Shi Maoning , Ma Yapeng , Pan Yunyan , Zhang Hui , Xie Xiaodong
Published: August 2023

The emergence of a vaccine against hepatitis B has proven to be an important milestone in the prevention of this disease; however, 5%–10% of vaccinated individuals do not generate an immune response to the vaccine, and its molecular mechanism has not been clarified. In this study, single-cell RNA sequencing was performed on peripheral blood mononuclear cells (PBMCs) from three volunteers with a high immune response (HR) and three with no immune response (NR) to the hepatitis B vaccine. We found that the antigen-presenting activity scores of various antigen-presenting cells, the mitogen-activated protein kinase (MAPK) pathway activity scores of naive B cells, and the cell activity scores of three types of effector T cells were significantly decreased, whereas the cytotoxicity scores of CD3highCD16lowKLRG1high natural killer T (NKT) cells were significantly increased in the NR group compared with those in the HR group. Additionally, the expression levels of some classical molecules associated with distinct signaling pathways—including HLA-B, HLA-DRB5, BLNK, BLK, IL4R, SCIMP, JUN, CEBPB, NDFIP1, and TXNIP—were significantly reduced in corresponding subsets of PBMCs from the NR group relative to those of the HR group. Furthermore, the expression of several cytotoxicity-related effector molecules, such as GNLY, NKG7, GZMB, GZMM, KLRC1, KLRD1, PRF1, CST7, and CTSW, was significantly higher in CD3highCD16lowKLRG1high NKT cells derived from non-responders. Our study provides a molecular basis for the lack of response to the hepatitis B vaccine, including defective antigen presentation, decreased T cell activity, and reduced IL-4 secretion, as well as novel insight into the role of NKT cells in the immune response to the hepatitis B vaccine.
T cell immune response predicts survival in severely ill COVID-19 patients requiring venovenous extracorporeal membrane oxygenation support
Authors: Ulakcsai Zsuzsanna , Szabo Liliana , Szabo Zsofia , Karaszi Eva , Szabo Tamas , Fazekas Levente , Vereb Alexandra , Kovacs Nora Fanna , Nemeth Dora , Kovacs Eniko , Nemeth Endre , Nagy Gyorgy , Vago Hajnalka , Merkely Bela
Published: August 2023

Introduction

There is a critical gap in understanding which SARS-CoV-2 patients would benefit most from venovenous extracorporeal membrane oxygenation (VV-ECMO) support. The potential role of a dysregulated immune response is still unclear in this patient population.

Objectives

To assess the potential predictive value of SARS-CoV-2 specific cellular and humoral immune responses for survival in critically ill COVID-19 patients requiring VV-ECMO.

Methods

We conducted a prospective single-center observational study of unvaccinated patients requiring VV-ECMO support treated at the intensive care unit of Semmelweis University Heart and Vascular Center between March and December 2021. Peripheral blood samples were collected to measure the humoral and cellular immune statuses of the patients at the VV-ECMO cannulation. Patients were followed until hospital discharge.

Results

Overall, 35 COVID-19 patients (63% men, median age 37 years) on VV-ECMO support were included in our study. The time from COVID-19 verification to ECMO support was a median (IQR) of 10 (7-14) days. Of the patients, 9 (26%) were discharged alive and 26 (74%) died during their hospital stay. Immune tests confirmed ongoing SARS-CoV-2 infection in all the patients, showing an increased humoral immune response. SARS-CoV-2-specific cellular immune response was significantly higher among survivors compared to the deceased patients. A higher probability of survival was observed in patients with markers indicating a higher T cell response detected by both QuantiFeron (QF) and flow cytometry (Flow) assays. (Flow S1 CD8+ ≥ 0.15%, Flow S1 CD4+ ≥ 0.02%, QF CD4 ≥ 0.07, QF whole genome ≥ 0.59). In univariate Cox proportional hazard regression analysis BMI, right ventricular (RV) failure, QF whole genome T cell level, and Flow S1 CD8+ T cell level were associated with mortality, and we found that an increased T cell response showed a significant negative association with mortality, independent of BMI and RV failure.

Conclusion

Evaluation of SARS-CoV-2 specific T cell response before the cannulation can aid the risk stratification and evaluation of seriously ill COVID-19 patients undergoing VV-ECMO support by predicting survival, potentially changing our clinical practice in the future.
Metabolomic and transcriptomic profiling reveals the effect of dietary protein and lipid levels on growth performance in loach (Paramisgurnus dabryanus)
Authors: Wang Zi-Rui , Li Shu-Yao , Zhang Ya-Zhou , Li Yong-An , Huo Huan-Huan , Yu Chuan-Qi , Zhou Qiu-Bai
Published: August 2023

The subject of this study was to explore the optimum requirements of loach (Paramisgurnus dabryanus) regarding dietary proteins and lipids and discuss the underlying mechanism. We designed nine diets to determine the effects of different levels of dietary crude protein (CP: 30%, 35%, and 40%) and ether extract (EE: 6%, 10%, and 14%) on the growth performance and metabolism of P. dabryanus. In total, 2160 healthy P. dabryanus (5.19 ± 0.01 g) were divided into nine groups with four replications at 60 fish per barrel stocking density. The trial lasted for eight weeks. Serum and liver samples were gathered for metabolomic and transcriptomic analyses. The results showed that the specific growth rate of P. dabryanus in the CP40EE10 group was the fastest and notably higher than that in other groups (P< 0.05). Analysis of the metabolome results found that the mTOR signaling pathway, glycerophospholipid metabolism, D-arginine and D-ornithine metabolism were significantly enriched pathways in the CP40EE10 group compared with the other groups (P< 0.05). Moreover, the transcriptomic analysis of differentially expressed genes (DEGs) showed that the expression of ARG (arginase) involved in protein synthesis was significantly upregulated in the CP40EE10 group compared to the slowest growing group (P< 0.05). Additionally, the expression of SPLA2 (secretory phospholipase A2) involved in lipid metabolism and FBP (fructose-1,6-bisphosphatase) involved in glucose metabolism were all significantly downregulated in the CP30EE6 group compared with the CP40EE10 group (P< 0.05). Furthermore, the analysis of differentially expressed metabolites (DEMs) and DEGs co-enriched in the KEGG pathway revealed that the significantly enriched pathways were arginine and proline metabolism, glycerophospholipid metabolism, and glycolysis/gluconeogenesis in CP40EE10 compared with other groups (P< 0.05). We conclude that including 40% CP and 10% EE in the P. dabryanus diet could result in a better growth rate. We hypothesized from metabolomic and transcriptomic analyses that the CP40EE10 diet might promote the growth of P. dabryanus by promoting protein synthesis, lipid metabolism, and energy production.
Potential benefits and risks of solar photovoltaic power plants on arid and semi-arid ecosystems: an assessment of soil microbial and plant communities
Authors: Liu Ziyu , Peng Tong , Ma Shaolan , Qi Chang , Song Yanfang , Zhang Chuanji , Li Kaile , Gao Na , Pu Meiyun , Wang Xiaomin , Bi Yurong , Na Xiaofan
Published: August 2023

Exponential increase in photovoltaic installations arouses concerns regarding the impacts of large-scale solar power plants on dryland ecosystems. While the effects of photovoltaic panels on soil moisture content and plant biomass in arid ecosystems have been recognized, little is known about their influence on soil microbial communities. Here, we employed a combination of quantitative PCR, high-throughput sequencing, and soil property analysis to investigate the responses of soil microbial communities to solar panel installation. We also report on the responses of plant communities within the same solar farm. Our findings showed that soil microbial communities responded differently to the shading and precipitation-alternation effects of the photovoltaic panels in an arid ecosystem. By redirecting rainwater to the lower side, photovoltaic panels stimulated vegetation biomass and soil total organic carbon content in the middle and in front of the panels, positively contributing to carbon storage. The shade provided by the panels promoted the co-occurrence of soil microbes but inhibited the abundance of 16S rRNA gene in the soil. Increase in precipitation reduced 18S rRNA gene abundance, whereas decrease in precipitation led to decline in plant aboveground biomass, soil prokaryotic community alpha diversity, and dehydrogenase activity under the panels. These findings highlight the crucial role of precipitation in maintaining plant and soil microbial diversities in dryland ecosystems and are essential for estimating the potential risks of large-scale solar power plants on local and global climate change in the long term.
Racial disparities in access to DBS: results of a real-world U.S. claims data analysis
Authors: Frassica Michael , Kern Drew S. , Afshari Mitra , Connolly Allison T. , Wu Chengyuan , Rowland Nathan , Ramirez-Castaneda Juan , Ushe Mwiza , Salazar Claudia , Mason Xenos
Published: August 2023

Introduction

Deep brain stimulation (DBS) is an effective and standard-of-care therapy for Parkinson’s Disease and other movement disorders when symptoms are inadequately controlled with conventional medications. It requires expert care for patient selection, surgical targeting, and therapy titration. Despite the known benefits, racial/ethnic disparities in access have been reported. Technological advancements with smartphone-enabled devices may influence racial disparities. Real-world evidence investigations can shed further light on barriers to access and demographic disparities for DBS patients.

Methods

A retrospective cross-sectional study was performed using Medicare claims linked with manufacturer patient data tracking to analyze 3,869 patients who received DBS. Patients were divided into two categories: traditional omnidirectional DBS systems with dedicated proprietary controllers (“traditional”; n = 3,256) and directional DBS systems with smart controllers (“smartphone-enabled”; n = 613). Demographics including age, sex, and self-identified race/ethnicity were compared. Categorical demographics, including race/ethnicity and distance from implanting facility, were analyzed for the entire population.

Results

A significant disparity in DBS utilization was evident. White individuals comprised 91.4 and 89.9% of traditional and smartphone-enabled DBS groups, respectively. Non-White patients were significantly more likely to live closer to implanting facilities compared with White patients.

Conclusion

There is great racial disparity in utilization of DBS therapy. Smartphone-enabled systems did not significantly impact racial disparities in receiving DBS. Minoritized patients were more likely to live closer to their implanting facility than White patients. Further research is warranted to identify barriers to access for minoritized patients to receive DBS. Technological advancements should consider the racial discrepancy of DBS utilization in future developments.
The relationship between PM2.5 and the onset and exacerbation of childhood asthma: a short communication
Authors: Zhang Yue , Yin Xixi , Zheng Xiangrong
Published: August 2023

Much is known about the link between air pollution and asthma in adults, particularly fine particulate matter (PM2.5). Studies have found that certain levels of fine PM2.5 can increase airway responsiveness and worsen asthma. PM2.5 may play a role in the onset and exacerbation of childhood asthma. However, there is little in the literature on how PM2.5 affects asthma attacks and exacerbations in children. Asthma is a common chronic disease in children, and air pollution can aggravate it. The effect of PM2.5 on childhood asthma needs further research. By evaluating, reviewing, and collating existing results in this area, this paper aims to explore the relationship between PM2.5 and asthma onset and exacerbation in children.
The roots of metaphor: the essence of thought
Authors: Colston Herbert L.
Published: August 2023

The essence of metaphor’s reliance on two domains, a source and a target, is argued as stemming from a fundamental characteristic of higher cognition—that of conceptualizing more than one cognitive/embodied domain at the same time. This cognitive duality is argued to underlie a plethora of conceptual activities including comparison, contrast, categorization, as well as metaphorizing. Why “two” domains seems the emergent and optimal means of such meta-cognition, rather than a higher number of domains, which might confer some advantages, is argued to arise from a grand compromise between an extreme necessity of humans to create and rely-upon shared complex meanings, and the complexities in enabling such shared meaning across multiple domains.
Residence in segregated settlements (colonies) rather than Roma identity increases the risk of unfavourable mental health in Hungarian adults
Authors: Oláh Barnabás , Bíró Éva , Kósa Karolina
Published: August 2023

Background

Roma are the largest and most disadvantaged minority in Europe, but there is few research on how mental health and social support of Roma people living in segregated settlements compares to the majority population. Our aim was to compare the subjective well-being, life satisfaction, mental status, and social support of representative samples of adults living in segregated settlements (colonies) and identifying as Roma with those of the general population in Hungary.

Methods

A cross-sectional study was conducted with random samples of 417 individuals from the general Hungarian adult population (55.6% female, mean age = 43.89 ± 12.61 years) and 394 adults living in segregated settlements (colonies) (73.9% female, mean age = 42.37 ± 12.39 years). Demographic questions were used as well as the WHO Well-Being Index (WBI-5), the single item Life Satisfaction Scale, the 12-item version of the General Health Questionnaire (GHQ-12), and the Oslo Social Support Scale (OSSS-3).

Results

Residents of colonies reported significantly lower levels of subjective well-being and life satisfaction than the general population. The proportion of individuals at high risk for mental morbidity was more than twice as high among colony dwellers (16.4%) as in non-colony dwellers (7.6%). Similar unfavorable differences were seen at the expense of self-identified Roma compared to self-identified Hungarians but no difference was found in terms of social support either by type of residence or ethnicity. 32.2% of colony-dwellers self-identified themselves as Hungarian. Mental health assessed by principal component was directly determined by settlement type of permanent residence, age, educational attainment, employment, financial status, and social support but not ethnic identity.

Conclusion

The study based on representative data shows that residents of segregated settlements are in worse mental health than those not living in colonies; that housing segregation is not limited to Roma people, and that housing conditions and financial status are major social determinants of mental health for which data must be collected to avoid using self-reported Roma identity as a proxy measure of socioeconomic deprivation.
Surveillance of clinical research integrity in medically assisted reproduction: a systematic review of retracted publications
Authors: Minetto Sabrina , Zanirato Mara , Makieva Sofia , Marzanati Daria , Esposito Stefania , Pisaturo Valerio , Costa Mauro , Candiani Massimo , Papaleo Enrico , Alteri Alessandra
Published: August 2023

Background and purpose

Retraction is a significant consequence of scientific research, resulting from various factors ranging from unintentional errors to intentional misconduct. Previous reviews on retracted publications in obstetrics and gynecology have identified “article duplication,” “plagiarism,” and “fabricated results” as the main reasons for retraction. However, the extent of retracted articles in the literature on medically assisted reproduction (MAR) remains unclear. This systematic review aimed to assess the number and characteristics of retracted articles in the field of MAR.

Methods

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed for this study. A comprehensive literature search was conducted on the PubMed database from 1993 to February 2023, limited to English articles and including all 283 terms from the International Glossary on Infertility and Fertility Care. To identify retracted studies, a specific query combining the 283 terms from the glossary with a retraction-related keyword was used. Only studies focused on MAR and involving human subjects were included.

Results

The electronic search yielded a total of 523,067 records in the field of infertility and fertility care. Among these, a total of 2,458 records were identified as retracted. The citation retraction rate was found to be 0.47% (2,458/523,067; 95%CI 0.45–0.49), and the citation retraction rate for randomized controlled trials (RCTs) was 0.20% (93/45,616; 95%CI 0.16–0.25). A total of 39 retracted articles specifically related to MAR were identified. Among these, 41.0% were RCTs (n = 16), 15.4% were reviews (n = 6), and 10.3% were retrospective studies (n = 4) or prospective studies (n = 4). Most of the retractions occurred shortly after publication, with “plagiarism” being the most common reason for retraction, followed by “duplicate publication.”

Discussion

The issue of retraction exists within the field of infertility and fertility care, including MAR. Our findings indicate that scientific misconduct, particularly plagiarism and duplicate publication, are the primary causes of retraction in MAR. Despite finding that the proportion of retracted citations is low, promoting scientific integrity should be a priority. The consequences of article retractions have significant implications for patient care and the scientific community. Hence, it is crucial to prioritize thorough screening of manuscripts before publication to maintain research integrity.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=185769, PROSPERO, identifier: CRD42020185769.
Developing a single-session strategy for the implementation of take-home naloxone by community pharmacists using COM-B and design-thinking
Authors: Moullin Joanna C. , Ely Philip , Uren Hannah , Staniland Lexy , Nielsen Suzanne , Lenton Simon
Published: August 2023

Background

Despite the overwhelming evidence of its effectiveness, there is poor implementation of take-home naloxone by pharmacists. Barriers have been explored and mapped to the capability, opportunity, motivation—behaviour (COM-B) model of behaviour change, yet no theoretically informed implementation strategies that target known barriers have been developed. Single-session implementation strategies have been proposed as a simple, scalable way to target multiple barriers.

Methods

Qualitative participatory methods, incorporating design-thinking principles, were used to develop the key messages of a single-session implementation strategy. The key messages were drafted against COM-B mapped implementation barriers identified in the literature. A participatory workshop involving a pre-mortem exercise and incorporating design-thinking principles were used to refine the messages and generate methods for dissemination. Messages were mapped to interview questions to naturally illicit stories and delivered via storytelling from a pharmacist, a general practitioner, and a person with lived experience of using naloxone.

Results

A 3 minute 40 second video and a two-page printable infographic were developed and hosted on a website, with links to additional downloadable resources as a single-session implementation strategy. Email was the preferred method for receiving simple professional development communications, with social media also widely accessed.

Discussion

Implementation science, behavioural change theory, and participatory design methods are a complementary combination to develop implementation strategies. Some pharmacists questioned the participatory design approach to developing an implementation strategy, as it was outside of their comfort zone. However, the participatory process involving end-users resulted in unique ideas that are unlikely to have been generated using more traditional consultative approaches. The delivery as a single-session implementation strategy allows for widespread dissemination and delivery at scale.
Electricity price modeling from the perspective of start-up costs: incorporating renewable resources in non-convex markets
Authors: Wesseh Presley K. , Chen Jiaying , Lin Boqiang
Published: August 2023

This paper constructs a comprehensive electricity market model in the context of China, highlighting the deviation caused by neglecting start-up costs from an engineering perspective. The model allows for the abandonment of excess wind and solar power generation, contributing to the achievement of research objectives in scenarios with a high proportion of renewable energy. Our method innovatively integrates fuel and carbon prices, clean energy expansion, and power system marginal prices according to the carbon trading rules of the Chinese power industry, providing a more accurate representation of market dynamics. Findings reveal that neglecting start-up costs can lead to significant biases in electricity prices. We demonstrate that the marginal price sometimes deviates from the fluctuation of the real value. While fuel and CO2 prices can be transmitted downstream, the value of new energy must be transmitted through its impact on the marginal unit. This insight is crucial for understanding the “missing money” problem in electricity markets. Based on these findings, we propose policy recommendations. We suggest considering fixed and average costs as pricing benchmarks and utilizing capacity utilization as a signal for demand response to adjust power pricing. Furthermore, we recommend trading different energy types separately in the spot market with different pricing benchmarks to ensure the homogeneity of marginal units.
Joint Encryption Model Based on a Randomized Autoencoder Neural Network and Coupled Chaos Mapping
Authors: Hu Anqi , Gong Xiaoxue , Guo Lei
Published: August 2023

Following an in-depth analysis of one-dimensional chaos, a randomized selective autoencoder neural network (AENN), and coupled chaotic mapping are proposed to address the short period and low complexity of one-dimensional chaos. An improved method is proposed for synchronizing keys during the transmission of one-time pad encryption, which can greatly reduce the usage of channel resources. Then, a joint encryption model based on randomized AENN and a new chaotic coupling mapping is proposed. The performance analysis concludes that the encryption model possesses a huge key space and high sensitivity, and achieves the effect of one-time pad encryption. Experimental results show that this model is a high-security joint encryption model that saves secure channel resources and has the ability to resist common attacks, such as exhaustive attacks, selective plaintext attacks, and statistical attacks.
Numerical Study of a High-Temperature Latent Heat Thermal Energy Storage Device with AlSi12 Alloy
Authors: Chaomurilige  , Qiao Geng , Zhao Peng , Li Yang , Li Yongliang
Published: August 2023

This paper explores the potential of thermal storage as an energy storage technology with cost advantages. The study uses numerical simulations to investigate the impact of adding porous material to the HTF side during solidification to improve the heat transfer effect of TES using AlSi12 alloy as the phase-change material. The research also examines the effects of adding porous dielectric materials and increasing air velocity on the discharge temperature, discharge power, and discharge time of high-temperature phase-change energy storage systems. The study found that the temperature difference of the PCM (increased), solidification time (reduced more than 85%), the outlet temperature of the air, and heat discharge power of the LHS did not vary significantly across different porous materials (copper foam, nickel foam, and silicon carbide foam) added to the HTF tube. These findings offer important information for the design of high-temperature phase-change energy storage devices and can guide future developments in this field.
Joint Detection and State Estimate with GSAs in PMU-Based Smart Grids
Authors: Hua Feng , Gao Wengen , Li Yunfei , Hu Pengfei , Qiao Lina
Published: August 2023

The Phasor Measurement Unit (PMU) with a GPS signal receiver is a synchronized sensor widely used for power system state estimation. While the GPS receiver ensures time accuracy, it is vulnerable to network attacks. GPS spoofing attacks can alter the phase angle of PMU measurement signals and manipulate system states. This paper derives a power system state model based on PMUs under GPS spoofing attacks, according to the characteristics of changes in bus voltages and branch currents after GSA. Based on the characteristics of this model, a detection and correction algorithm for attacked data is proposed to detect GSA and correct attacked measurements. The corrected measurements can be used for power system state estimation. Simulation results on the IEEE 14-bus system show that the proposed algorithm improves the accuracy of state estimation under one or multiple GSAs, especially when multiple GSAs are present, compared to classical Weighted Least Squares Estimation (WLSE) and Alternating Minimization (AM) algorithms. Further research indicates that this algorithm is also applicable to large-scale networks.
Bibliometric Analysis of Research Trends on Quantum-Dot-Sensitized Solar Cells over Two Decades
Authors: Dan Ho , Tung Ha , Khanh Duong , Nguyen Ho
Published: August 2023

Many years after the introduction of quantum-dot-sensitized solar cells (QDSSCs), publications related to it have been widely disseminated in scientific archives. In this study, a bibliometric analysis was conducted to examine the bibliographic content of publications indexed in the Science Citation Index Expanded database from 2000 to 2021. Over the past two decades, 1557 articles have been published in the field of QDSSCs, covering studies on the photoanode, cathode, and electrolytes of the system. The most active journal, Electrochimica Acta, has published 6.48% of the total number of publications. The three most productive nations are China, South Korea, and India, accounting for 47.4%, 13%, and 9%, respectively, of publications from the top 20 nations. Through keyword analysis, our findings suggest that scholars have focused on controlling the optical and electrochemical properties of active materials, studying power conversion mechanisms, and investigating other internal kinetic mechanisms of QDSSCs. The authors and institutions are also classified based on their scientific performance over the past two decades to determine the intellectual base. This study assesses the general progression in QDSSC research and may provide baseline information to help scholars identify research trends in the field of QDSSCs.
Research into a Method of Forming Neutral Point Voltage in a Three-Phase Four-Wire Voltage Inverter
Authors: Dar’enkov Andrey , Kurkin Andrey , Sluzov Anton , Berdnikov Ivan , Khramov Anton , Shalukho Andrey
Published: August 2023

Three-phase four-wire voltage inverters are commonly used in energy complexes based on distributed generation sources (solar panels, wind power plants, hydrogen fuel cells) and accumulator batteries. They allow to power loads, including single-phase ones, which require neutral point connection. In these cases, phase voltage formed by spatial pulse-width modulation (PWM) methods considerably differs from sinusoidal waves and has high total harmonic distortions of voltage and current curves. This article is devoted to research into the authors’ control method of a three-phase four-wire inverter, allowing for the rectification of the form of phase voltage supplying the load when applying the most common PWM (SVPWM, DPWMMIN, DPWMMAX, GDPWM) methods. The description of the method and its research results by simulation modeling and test bench are presented in the article. The simulation modeling was carried out by the developed Simulink-model of the three-phase four-wire inverter and its control system. The modeling results showed that the method application ensures sinusoidal voltage form when applying any PWM method. At this, THDU was reduced from 21.56% to 4.39%, while THDI was reduced from 21.16% to 1.69%. Experimental tests were carried out by a test bench featuring an uninterruptible power supply source. The authors researched the inverter operation as a component of the test bench under the control of the proposed method to form neutral point voltage. The experimental test results coincided with the simulation modeling results.
Anaerobic Digestion of Food Waste—A Short Review
Authors: Pilarska Agnieszka A. , Kulupa Tomasz , Kubiak Adrianna , Wolna-Maruwka Agnieszka , Pilarski Krzysztof , Niewiadomska Alicja
Published: August 2023

In recent years, growing environmental awareness, the need to reduce greenhouse gas emissions, and the energy crisis have led many countries to seek alternative energy sources. One of the most promising solutions is biogas production via anaerobic digestion (AD), whose substrate can be organic-rich and easily biodegradable food waste (FW). This waste is a significant part of the global waste problem, and its use for energy production is beneficial to both the environment and the economy. This paper presents important issues concerning the monitoring of the AD process, as well as standard and innovative, for the implementation of this process, technological solutions. The aim of the measures taken to optimise the process is to increase AD efficiency and obtain the highest possible methane content in biogas. Two approaches—pretreatment and anaerobic co-digestion (AcoD)—have been integral to the implementation of AD of food waste for years. They are presented in this paper based on a review of recent research developments. Pretreatment methods are discussed with particular emphasis on mechanical, chemical and biological methods. The AcoD of FW with different organic substrates has been extensively reviewed, as confirmed by numerous studies, where higher buffer capacity and optimum nutrient balance enhance the biogas/methane yields. Attention was also paid to the parameters, operating mode and configurations of anaerobic digesters, with a thorough analysis of the advantages and disadvantages of each solution. The article concludes with a brief presentation of the development perspectives for the discussed FW management method and recommendations.
Experimental Comparison of Hydrogen Refueling with Directly Pressurized vs. Cascade Method
Authors: Genovese Matteo , Blekhman David , Dray Michael , Piraino Francesco , Fragiacomo Petronilla
Published: August 2023

This paper presents a comparative analysis of two hydrogen station configurations during the refueling process: the conventional “directly pressurized refueling process” and the innovative “cascade refueling process.” The objective of the cascade process is to refuel vehicles without the need for booster compressors. The experiments were conducted at the Hydrogen Research and Fueling Facility located at California State University, Los Angeles. In the cascade refueling process, the facility buffer tanks were utilized as high-pressure storage, enabling the refueling operation. Three different scenarios were tested: one involving the cascade refueling process and two involving compressor-driven refueling processes. On average, each refueling event delivered 1.6 kg of hydrogen. Although the cascade refueling process using the high-pressure buffer tanks did not achieve the pressure target, it resulted in a notable improvement in the nozzle outlet temperature trend, reducing it by approximately 8 °C. Moreover, the overall hydrogen chiller load for the two directly pressurized refuelings was 66 Wh/kg and 62 Wh/kg, respectively, whereas the cascading process only required 55 Wh/kg. This represents a 20% and 12% reduction in energy consumption compared to the scenarios involving booster compressors during fueling. The observed refueling range of 150–350 bar showed that the cascade process consistently required 12–20% less energy for hydrogen chilling. Additionally, the nozzle outlet temperature demonstrated an approximate 8 °C improvement within this pressure range. These findings indicate that further improvements can be expected in the high-pressure region, specifically above 350 bar. This research suggests the potential for significant improvements in the high-pressure range, emphasizing the viability of the cascade refueling process as a promising alternative to the direct compression approach.
Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology
Authors: García-Yagüe Ángel Juan , Cuadrado Antonio
Published: August 2023

NURR1 (Nuclear receptor-related 1 protein or NR4A2) is a nuclear protein receptor transcription factor with an essential role in the development, regulation, and maintenance of dopaminergic neurons and mediates the response to stressful stimuli during the perinatal period in mammalian brain development. The dysregulation of NURR1 activity may play a role in various diseases, including the onset and progression of neurodegenerative diseases, and several other pathologies. NURR1 is regulated by multiple mechanisms, among which phosphorylation by kinases or SUMOylation are the best characterized. Both post-translational modifications can regulate the activity of NURR1, affecting its stability and transcriptional activity. Other non-post-translational regulatory mechanisms include changes in its subcellular distribution or interaction with other protein partners by heterodimerization, also affecting its transcription activity. Here, we summarize the currently known regulatory mechanisms of NURR1 and provide a brief overview of its participation in pathological alterations.
Polynucleotides Suppress Inflammation and Stimulate Matrix Synthesis in an In Vitro Cell-Based Osteoarthritis Model
Authors: Kuppa Sree Samanvitha , Kim Hyung-Keun , Kang Ju-Yeon , Lee Seok-Cheol , Yang Hong-Yeol , Sankaranarayanan Jaishree , Seon Jong-Keun
Published: August 2023

Osteoarthritis (OA) is characterized by degeneration of the joint cartilage, inflammation, and a change in the chondrocyte phenotype. Inflammation also promotes cell hypertrophy in human articular chondrocytes (HC-a) by activating the NF-κB pathway. Chondrocyte hypertrophy and inflammation promote extracellular matrix degradation (ECM). Chondrocytes depend on Smad signaling to control and regulate cell hypertrophy as well as to maintain the ECM. The involvement of these two pathways is crucial for preserving the homeostasis of articular cartilage. In recent years, Polynucleotides Highly Purified Technology (PN-HPT) has emerged as a promising area of research for the treatment of OA. PN-HPT involves the use of polynucleotide-based agents with controlled natural origins and high purification levels. In this study, we focused on evaluating the efficacy of a specific polynucleotide sodium agent, known as CONJURAN, which is derived from fish sperm. Polynucleotides (PN), which are physiologically present in the matrix and function as water-soluble nucleic acids with a gel-like property, have been used to treat patients with OA. However, the specific mechanisms underlying the effect remain unclear. Therefore, we investigated the effect of PN in an OA cell model in which HC-a cells were stimulated with interleukin−1β (IL−1β) with or without PN treatment. The CCK-8 assay was used to assess the cytotoxic effects of PN. Furthermore, the enzyme-linked immunosorbent assay was utilized to detect MMP13 levels, and the nitric oxide assay was utilized to determine the effect of PN on inflammation. The anti-inflammatory effects of PN and related mechanisms were investigated using quantitative PCR, Western blot analysis, and immunofluorescence to examine and analyze relative markers. PN inhibited IL−1β induced destruction of genes and proteins by downregulating the expression of MMP3, MMP13, iNOS, and COX-2 while increasing the expression of aggrecan (ACAN) and collagen II (COL2A1). This study demonstrates, for the first time, that PN exerted anti-inflammatory effects by partially inhibiting the NF-κB pathway and increasing the Smad2/3 pathway. Based on our findings, PN can potentially serve as a treatment for OA.
Unravelling the Role of Uncommon Hydrogen Bonds in Cyclodextrin Ferrociphenol Supramolecular Complexes: A Computational Modelling and Experimental Study
Authors: Pigeon Pascal , Najlaoui Feten , McGlinchey Michael James , Sanz García Juan , Jaouen Gérard , Gibaud Stéphane
Published: August 2023

We sought to determine the cyclodextrins (CDs) best suited to solubilize a patented succinimido-ferrocidiphenol (SuccFerr), a compound from the ferrociphenol family having powerful anticancer activity but low water solubility. Phase solubility experiments and computational modelling were carried out on various CDs. For the latter, several CD-SuccFerr complexes were built starting from combinations of one or two CD(s) where the methylation of CD oxygen atoms was systematically changed to end up with a database of ca. 13 k models. Modelling and phase solubility experiments seem to indicate the predominance of supramolecular assemblies of SuccFerr with two CDs and the superiority of randomly methylated β-cyclodextrins (RAMEβCDs). In addition, modelling shows that there are several competing combinations of inserted moieties of SuccFerr. Furthermore, the models show that ferrocene can contribute to high stabilization by making atypical hydrogen bonds between Fe and the hydroxyl groups of CDs (single bond with one OH or clamp with two OH of the same glucose unit).
Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases
Authors: Bernatoniene Jurga , Jakstas Valdas , Kopustinskiene Dalia M.
Published: August 2023

The roots and rhizomes of Rhodiola rosea L. (Crassulaceae), which is widely growing in Northern Europe, North America, and Siberia, have been used since ancient times to alleviate stress, fatigue, and mental and physical disorders. Phenolic compounds: phenylpropanoids rosavin, rosarin, and rosin, tyrosol glucoside salidroside, and tyrosol, are responsible for the biological action of R. rosea, exerting antioxidant, immunomodulatory, anti-aging, anti-fatigue activities. R. rosea extract formulations are used as alternative remedies to enhance mental and cognitive functions and protect the central nervous system and heart during stress. Recent studies indicate that R. rosea may be used to treat diabetes, cancer, and a variety of cardiovascular and neurological disorders such as Alzheimer’s and Parkinson’s diseases. This paper reviews the beneficial effects of the extract of R. rosea, its key active components, and their possible use in the treatment of chronic diseases. R. rosea represents an excellent natural remedy to address situations involving decreased performance, such as fatigue and a sense of weakness, particularly in the context of chronic diseases. Given the significance of mitochondria in cellular energy metabolism and their vulnerability to reactive oxygen species, future research should prioritize investigating the potential effects of R. rosea main bioactive phenolic compounds on mitochondria, thus targeting cellular energy supply and countering oxidative stress-related effects.
The Potential Role of the Piwi Gene in the Development and Reproduction of Plutella xylostella
Authors: Liu Dan , Asad Muhammad , Liao Jianying , Chen Jing , Li Jianwen , Chu Xuemei , Pang Senbo , Tariq Mubashir , Abbas Anam Noreen , Yang Guang
Published: August 2023

Piwi proteins play a significant role in germ cell development and the silencing of transposons in animals by associating with small non-coding RNAs known as Piwi-interacting RNAs (piRNAs). While the Piwi gene has been well characterized in various insect species, the role of the Piwi (PxPiwi) gene in the diamondback moth (Plutella xylostella), a globally distributed pest of cruciferous crops, remains unclear. Expression analysis demonstrated the upregulation of PxPiwi in pupae and testes. Furthermore, we generated a PxPiwi-knockout mutant using CRISPR/Cas9 technology, which resulted in a significantly prolonged pupal stage and the failure of pupae to develop into adults. Additionally, the knockdown of PxPiwi, through RNA interference (RNAi), led to a substantial decrease in the oviposition and hatchability of P. xylostella. These findings indicate that PxPiwi is specifically expressed and essential for the development and reproduction of P. xylostella. This is the first report indicating the involvement of the Piwi gene in the development of lepidopteran insects, except for reproduction and germ cell development, which provides a foundation for future investigations into the functions of PxPiwi.
High-Throughput Screening of High-Performance Thermoelectric Materials with Gibbs Free Energy and Electronegativity
Authors: Xu Guiying , Xin Jiakai , Deng Hao , Shi Ran , Zhang Guangbing , Zou Ping
Published: August 2023

Thermoelectric (TE) materials are an important class of energy materials that can directly convert thermal energy into electrical energy. Screening high-performance thermoelectric materials and improving their TE properties are important goals of TE materials research. Based on the objective relationship among the molar Gibbs free energy (Gm), the chemical potential, the Fermi level, the electronegativity (X) and the TE property of a material, a new method for screening TE materials with high throughput is proposed. This method requires no experiments and no first principle or Ab initio calculation. It only needs to find or calculate the molar Gibbs free energy and electronegativity of the material. Here, by calculating a variety of typical and atypical TE materials, it is found that the molar Gibbs free energy of Bi2Te3 and Sb2Te3 from 298 to 600 K (Gm = −130.20~−248.82 kJ/mol) and the electronegativity of Bi2Te3 and Sb2Te3 and PbTe (X = 1.80~2.21) can be used as criteria to judge the potential of materials to become high-performance TE materials. For good TE compounds, Gm and X are required to meet the corresponding standards at the same time. By taking Gm = −130.20~−248.82 kJ/mol and X = 1.80~2.21 as screening criteria for high performance TE materials, it is found that the Gm and X of all 15 typical TE materials and 9 widely studied TE materials meet the requirement very well, except for the X of Mg2Si, and 64 pure substances are screened as potential TE materials from 102 atypical TE materials. In addition, with reference to their electronegativity, 44 pure substances are selected directly from a thermochemical data book as potential high-performance TE materials. A particular finding is that several carbides, such as Be2C, CaC2, BaC2, SmC2, TaC and NbC, may have certain TE properties. Because the Gm and X of pure substances can be easily found in thermochemical data books and calculated using the X of pure elements, respectively, the Gm and X of materials can be used as good high-throughput screening criteria for predicting TE properties.