bluuebunny/crossref_metadata_2025 huggingface dataset:
Tissue Inhibitor of Metalloproteinases-1 Interacts with CD74 to Promote AKT Signaling, Monocyte Recruitment Responses, and Vascular Smooth Muscle Cell Proliferation
Authors: Ebert Simon , Zang Lan , Ismail Noor , Otabil Michael , Fröhlich Adrian , Egea Virginia , Ács Susann , Hoeberg Mikkel , Berres Marie-Luise , Weber Christian , Moreira José M. A. , Ries Christian , Bernhagen Jürgen , El Bounkari Omar
Published: July 2023

Tissue inhibitor of metalloproteinases-1 (TIMP-1), an important regulator of matrix metalloproteinases (MMPs), has recently been shown to interact with CD74, a receptor for macrophage migration inhibitory factor (MIF). However, the biological effects mediated by TIMP-1 through CD74 remain largely unexplored. Using sequence alignment and in silico protein–protein docking analysis, we demonstrated that TIMP-1 shares residues with both MIF and MIF-2, crucial for CD74 binding, but not for CXCR4. Subcellular colocalization, immunoprecipitation, and internalization experiments supported these findings, demonstrating that TIMP-1 interacts with surface-expressed CD74, resulting in its internalization in a dose-dependent manner, as well as with a soluble CD74 ectodomain fragment (sCD74). This prompted us to study the effects of the TIMP-1–CD74 axis on monocytes and vascular smooth muscle cells (VSCMs) to assess its impact on vascular inflammation. A phospho-kinase array revealed the activation of serine/threonine kinases by TIMP-1 in THP-1 pre-monocytes, in particular AKT. Similarly, TIMP-1 dose-dependently triggered the phosphorylation of AKT and ERK1/2 in primary human monocytes. Importantly, Transwell migration, 3D-based Chemotaxis, and flow adhesion assays demonstrated that TIMP-1 engagement of CD74 strongly promotes the recruitment response of primary human monocytes, while live cell imaging studies revealed a profound activating effect on VSMC proliferation. Finally, re-analysis of scRNA-seq data highlighted the expression patterns of TIMP-1 and CD74 in human atherosclerotic lesions, thus, together with our experimental data, indicating a role for the TIMP-1–CD74 axis in vascular inflammation and atherosclerosis.
FITC-Labeled RGD Peptides as Novel Contrast Agents for Functional Fluorescent Angiographic Detection of Retinal and Choroidal Neovascularization
Authors: Choi Seung Woo , Hong Hye Kyoung , Jeon Jehwi , Choi Ji Young , Kim Minah , Kim Pilhan , Lee Byung Chul , Woo Se Joon
Published: July 2023

The development of choroidal neovascularization (CNV) is a crucial factor in the pathophysiology and prognosis of exudative age-related macular degeneration (AMD). Therefore, the detection of CNV is essential for establishing an appropriate diagnosis and treatment plan. Current ophthalmic imaging techniques, such as fundus fluorescent angiography and optical coherence tomography, have limitations in accurately visualizing CNV lesions and expressing CNV activity, owing to issues such as excessive dye leakage with pooling and the inability to provide functional information. Here, using the arginine−glycine−aspartic acid (RGD) peptide’s affinity for integrin αvβ3, which is expressed in the neovascular endothelial cells in ocular tissues, we propose the use of fluorescein isothiocyanate (FITC)-labeled RGD peptide as a novel dye for effective molecular imaging of CNV. FITC-labeled RGD peptides (FITC-RGD2), prepared by bioconjugation of one FITC molecule with two RGD peptides, demonstrated better visualization and precise localization of CNV lesions than conventional fluorescein dyes in laser-induced CNV rodent models, as assessed using various imaging techniques, including a commercially available clinical fundus camera (Optos). These results suggest that FITC-RGD2 can serve as an effective novel dye for the diagnosis of neovascular retinal diseases, including AMD, by enabling early detection and treatment of disease occurrence and recurrence after treatment.
Neurological Symptoms That May Represent a Warning in Terms of Diagnosis and Treatment in a Group of Children and Adolescents with Vitamin D Deficiency
Authors: Korkut Oguzhan , Aydin Hilal
Published: July 2023

Aim: This research was intended to evaluate the clinical and laboratory findings of children presenting to our pediatric neurology clinic with symptoms potentially linked to vitamin D deficiency and with low vitamin D levels and the distribution of those findings by sex, age groups, and vitamin D levels. Methods: This retrospective study involved patients presenting to our clinic with symptoms potentially associated with vitamin D deficiency and low serum concentrations of 25 OH vitamin D (25 OH D) (<75 nmol/L, 30 µg/mL). Patients’ movement disorders and central nervous system-related symptoms at the time of presentation and serum 25 OH D, calcium (Ca), phosphorus (P), and magnesium (Mg) levels were recorded and evaluated in terms of age, sex, and vitamin D levels. Results: Eight hundred twenty-two cases of vitamin D deficiency were included in the study, 50.2% (n = 413) boys and 49.8% (n = 409) girls. Although cases of vitamin D deficiency were present across all the age groups between 1 and 18, they were most common in the 5–14 age range (n = 372, 45.3%). Movement disorders were observed in 14.6% (n = 120) of our cases, and neurological findings associated with the central nervous system were observed in 52.6% (n = 432). The most common accompanying movement in our cases was difficulty remaining in balance (n = 42, 35%), while the most frequent accompanying central nervous system finding was vertigo (n = 99, 22.92%). Other movement disorders encountered included limb shaking (n = 32, 26.7%), abnormal posture (n = 20, 16.67%), easy falling (n = 16, 13.33%), body rigidity (n = 15, 12.5%), and hand clenching (n = 5, 4.17%). Other frequently encountered neurological findings were headache (n = 88, 20.37%), epileptic seizures (n = 83, 19.21%), fainting (n = 58, 13.43%), developmental delay (n = 41, 9.49%), febrile seizures (n = 33, 7.64%), and numbness in the fingers (n = 20, 4.63%). Other neurological findings were sleep disorders (n = 10, 2.31%), nightmares (n = 8, 1.85%), pain in the extremities (n = 7, 1.62%), and sweating and frailty (n = 4, 0.93% for both). Ca, P, and Mg levels were lower in cases with vitamin D levels < 12 µg/mL. The prevalences of both movement disorders and central nervous system findings varied according to age groups, sex, and vitamin D levels. Conclusions: Our study results show that vitamin D deficiency can present with different neurological findings and that these may vary according to age group, sex, and vitamin D levels. Clinicians must take particular care in pediatric cases with neurological findings in terms of the early diagnosis and treatment of vitamin D deficiency.
Contact Force-Guided versus Contact Force-Blinded Cavo-Tricuspid Isthmus Ablation for Atrial Flutter: A Systematic Review and Meta-Analysis
Authors: Abuelazm Mohamed , Mohamed Islam , Seri Amith Reddy , Almaadawy Omar , Abdelazeem Basel , Brašić James Robert
Published: July 2023

Contact force (CF) is a novel approach developed to increase the safety and efficacy of catheter ablation. However, the value of CF-sensing technology for atrial flutter (AFL) cavo-tricuspid isthmus ablation (CTIA) is inconclusive. To generate a comprehensive assessment of optimal extant data on CF for AFL, we synthesized randomized controlled trials (RCTs) and observational studies from Web of Science, SCOPUS, EMBASE, PubMed, and Cochrane until 29 November 2022, using the odds ratio (OR) for dichotomous outcomes and mean difference (MD) for continuous outcomes with a corresponding 95% confidence interval (CI). Two RCTs and three observational studies with a total of 376 patients were included in our analysis. CF-guided ablation was associated with (A) a higher rate of AFL recurrence (OR: 2.26 with 95% CI [1.05, 4.87]) and total CF (MD: 2.71 with 95% CI [1.28, 4.13]); (B) no effect on total procedure duration (MD: −2.88 with 95% CI [−7.48, 1.72]), fluoroscopy duration (MD: −0.96 with 95% CI [−2.24, 0.31]), and bidirectional isthmus block (BDIB) (OR: 1.50 with 95% CI [0.72, 3.11]); and (C) decreased radiofrequency (RF) duration (MD: −1.40 with 95% CI [−2.39, −0.41]). We conclude that although CF-guided CTIA was associated with increased AFL recurrence and total CF and reduced RF duration, it did not affect total procedure duration, fluoroscopy duration, or BDIB. Thus, CF-guided CTIA may not be the optimal intervention for AFL. These findings indicate the need for (A) providers to balance the benefits and risks of CF when utilizing precision medicine to develop treatment plans for individuals with AFL and (B) clinical trials investigating CF-guided catheter ablation for AFL to provide definitive evidence of optimal CF-sensing technology.
Numerical Investigation of a Solar-Heating System with Solar-Tower Receiver and Seasonal Storage in Northern China: Dynamic Performance Assessment and Operation Strategy Analysis
Authors: Li Xiaoxia , Qiu Husheng , Wang Zhifeng , Li Jinping , Yuan Guobin , Guo Xiao , Jin Lifeng
Published: July 2023

Solar-heating technology is a promising solution to help China achieve the “3060 double carbon” target as soon as possible. Seasonal thermal storage (STS) can effectively solve the mismatch problem of solar-heating systems between the supply and demand of thermal energy. Due to the instability of solar radiation resources and the heat demand, it is necessary to analyze the dynamic response characteristics and operation strategy optimization of the system in different operation stages. Yet, related studies are still scarce. The aim of this paper is to study the switching mechanism of the operation modes and the transitive relation of the system energy in different operation stages based on a pilot solar-heating system with STS in Huangdicheng, northern China. The impacts of different heating strategies on the system performance were also analyzed with a dynamic simulated method in TRNSYS. The results showed that the solar fraction of the system reached 89.4% in the third year, which was 3.6% higher than that in the first year. The quality–quantity heating operation strategies are effective ways to improve the discharge efficiency of the STS and the system performance without a heat pump. The electricity consumption of the pump on the heating side could be significantly reduced by 44.6% compared with the quality control. Ultimately, the findings in this paper are valuable for the optimization of the operation of solar-heating systems.
Effects of Pilates on Pain, Physical Function, Sleep Quality, and Psychological Factors in Young Women with Dysmenorrhea: A Preliminary Randomized Controlled Study
Authors: Song Bo-Hwa , Kim Jaehee
Published: July 2023

The effect of Pilates on dysmenorrhea has been little studied. The purpose of this study was to evaluate the effect of Pilates on menstrual pain and symptoms, premenstrual syndrome, and risk factors of dysmenorrhea. Thirty young women with primary dysmenorrhea were randomly assigned into a Pilates group (PG; n = 15) and a waitlist control group (CG; n = 15). The Pilates was performed twice a week for 12 weeks. Menstrual pain and symptoms were measured by visual analogue scale (VAS) and the Cox menstrual symptom scale (CMSS), respectively. Premenstrual syndrome was assessed using the premenstrual symptoms screening tool (PSST). Additionally, back flexibility, hip muscle strength, sleep duration and quality, perceived stress, state-trait anxiety, and depression were evaluated. The VAS, CMSS severity and frequency, and PSST symptoms and functional impairments decreased in the PG compared to the CG (p < 0.001 or p < 0.01) with large effect sizes. Back flexibility and the strength of hip flexors, hip extensors, and hip abductors significantly increased in the PG compared to the CG (all p < 0.01) with large effect sizes. Sleep quality (p < 0.01) and stress (p < 0.05) improved in the PG. Sleep duration, anxiety, and depression did not change in either group. In conclusion, the 12-week Pilates intervention ameliorates dysmenorrhea, partly mediated by improved physical function and sleep quality.
Concentric Isokinetic Strengthening Program’s Impact on Knee Biomechanical Parameters, Physical Performance and Quality of Life in Overweight/Obese Women with Chronic Meniscal Lesions
Authors: Hammami Nadhir , Mechraoui Amani , Hattabi Soukaina , Forte Pedro , Sampaio Tatiana , Sortwell Andrew , Teixeira José E. , Branquinho Luís , Ferraz Ricardo , Bouassida Anissa
Published: July 2023

Meniscal injuries are one of the most common intra-articular knee injuries. Different treatments are presented depending on the symptoms and duration of meniscus tears, such as arthroscopic partial meniscectomy, physiotherapy, or even pharmacological treatment. The purpose was to investigate the effect of a concentric isokinetic knee muscle strengthening program on strength, joint range of motion, physical performance, quality of life and pain tolerance in overweight/obese women with chronic meniscal lesions. Twenty-four overweight/obese women were randomized into two groups. A control group (CG) performed a usual rehabilitation program plus isokinetic muscle strengthening (IMS) in the continuous passive motion mode and measured with an isokinetic dynamometer. An experimental group (EG) performed the same program in combination with IMS in the isokinetic active mode. The peak torque of the knee extensors (PTE) and flexors (PTF), sit-to-stand test, stair climb test, joint amplitude, heel-to-buttock distance, Thessaly test, KOOS questionnaire of pain and quality of life were measured pre- and post-protocol. After the intervention, the sit–stand number for both groups was significantly higher (p < 0.001) and the time to climb stairs was significantly reduced for the EG (p < 0.001). A significant improvement in joint range of motion, life quality (p < 0.001), relief in knee pain (p < 0.001) and in the post-program evaluation at the EG (p < 0.05) was noted. There was no significant difference in PTE and PTF between groups at 60°/s and 180°/s. The IMS in the active mode could be an effective therapeutic modality in managing middle-aged patients suffering from a degenerative meniscal tear.
Modified Supine Percutaneous Nephrolithotomy in the Elderly: Outcomes and Safety
Authors: Lim Kylie Yen-Yi , Liew Amos Nepacina , Ling Zihui , Ranasinghe Weranja , McCahy Philip
Published: July 2023

With increases in the aging population, conditions affecting older people and relevant surgical techniques are becoming more pertinent. Modified supine percutaneous nephrolithotomy (PCNL) is increasingly being adopted. There are limited data on the safety of this position in the elderly patient population. We describe our experience of the modified supine position in patients aged 70 years and older. Between April 2011 and March 2021, patients aged 70 years and older undergoing a modified supine PCNL performed by a single surgeon were prospectively evaluated. Data including patient age, operative time, complications, stone clearance, and length of stay were collected and analysed. Sixty-nine procedures were performed on 67 patients with a mean age was 76.5 years. Median total operative time was 95 min with 20 (29%) patients having a combined procedure with ureterorenoscopy. Preoperative mean stone burden was 23.5 mm and complete stone clearance was achieved in 46 (66.7%) patients. Twelve (17.4%) patients had complications during their hospitalisation. Six were Clavien–Dindo class II or less and one Clavien–Dindo class V. The modified supine position for PCNL is safe in the elderly patient population and has advantages including reduced handling of patients and achieving adequate stone-free rates. These benefits are particularly important in the elderly population, which frequently has a reduced tolerance to adaptation.
New Perspective for Drug–Drug Interaction in Perioperative Period
Authors: Silva Abigail , Costa Bárbara , Castro Irene , Mourão Joana , Vale Nuno
Published: July 2023

In this review, we aim to discuss current information on drug interactions in the perioperative period. During this period, patients receive several drugs that may interact with each other and affect the efficacy and safety of the treatment. There are three types of drug interactions: pharmacodynamic, pharmacokinetic, and pharmaceutical. It is important to recognize that drug interactions may increase the toxicity of the drug or reduce its efficacy, increasing the risk of complications in the perioperative period. This review describes the most commonly used perioperative drugs approved by the FDA and some of the described interactions between them. Thoroughly reviewing a patient’s medication list and identifying potential interactions are essential steps in minimizing risks. Additionally, vigilant monitoring of patients during and after surgery plays a pivotal role in early detection of any signs of drug interactions. This article emphasizes the significance of addressing DDIs in the perioperative period to ensure patient well-being and advocates for the implementation of careful monitoring protocols to promptly identify and manage potential interactions.
Dynamics and Embedded Solitons of Stochastic Quadratic and Cubic Nonlinear Susceptibilities with Multiplicative White Noise in the Itô Sense
Authors: Li Zhao , Peng Chen
Published: July 2023

The main purpose of this paper is to study the dynamics and embedded solitons of stochastic quadratic and cubic nonlinear susceptibilities in the Itô sense, which can further help researchers understand the propagation of soliton nonlinear systems. Firstly, a two-dimensional dynamics system and its perturbation system are obtained by using a traveling wave transformation. Secondly, the phase portraits of the two-dimensional dynamics system are plotted. Furthermore, the chaotic behavior, two-dimensional phase portraits, three-dimensional phase portraits and sensitivity of the perturbation system are analyzed via Maple software. Finally, the embedded solitons of stochastic quadratic and cubic nonlinear susceptibilities are obtained. Moreover, three-dimensional and two-dimensional solitons of stochastic quadratic and cubic nonlinear susceptibilities are plotted.
Preface to the Special Issue on “Computational and Mathematical Methods in Information Science and Engineering”
Authors: Zhang Wen , Xu Xiaofeng , Wu Jun , He Kaijian
Published: July 2023

With the emergence of big data and the resulting information explosion, computational and mathematical methods provide effective tools to handle the vast amounts of data and information used in big data analytics, knowledge discovery and distillation, and decision-making for solving complex problems in the world [...]
High-Performance Time Series Anomaly Discovery on Graphics Processors
Authors: Zymbler Mikhail , Kraeva Yana
Published: July 2023

Currently, discovering subsequence anomalies in time series remains one of the most topical research problems. A subsequence anomaly refers to successive points in time that are collectively abnormal, although each point is not necessarily an outlier. Among numerous approaches to discovering subsequence anomalies, the discord concept is considered one of the best. A time series discord is intuitively defined as a subsequence of a given length that is maximally far away from its non-overlapping nearest neighbor. Recently introduced, the MERLIN algorithm discovers time series discords of every possible length in a specified range, thereby eliminating the need to set even that sole parameter to discover discords in a time series. However, MERLIN is serial, and its parallelization could increase the performance of discord discovery. In this article, we introduce a novel parallelization scheme for GPUs called PALMAD, parallel arbitrary length MERLIN-based anomaly discovery. As opposed to its serial predecessor, PALMAD employs recurrent formulas we have derived to avoid redundant calculations, and advanced data structures for the efficient implementation of parallel processing. Experimental evaluation over real-world and synthetic time series shows that our algorithm outperforms parallel analogs. We also apply PALMAD to discover anomalies in a real-world time series, employing our proposed discord heatmap technique to illustrate the results.
Study on Cortisol Sensing Principle Based on Fluorophore and Aptamer Competitive Assay on Polymer Optical Fiber
Authors: Semwal Vivek , Højgaard Jonas , Møller Emil , Bang Ole , Janting Jakob
Published: July 2023

In this study, we present a polymer optical fiber fluorophore/aptamer competitive assay-based cortisol sensing principle. We developed a low-cost, two-fiber perpendicular design for fluorophore-based sensing with less input light interference and high output signal intensity. The design is suitable for narrow stokes shift fluorophores. We have demonstrated the cortisol sensing principle based on the competition between tagged and normal cortisol. To date, the sensing design has exhibited a slow response, and we identified possible modifications for improvement. Our estimation shows that with miniaturization and a modified sensor assay compartment design, a less than one-hour response time can be achieved. The reported sensing principle and low-cost new design will be helpful for the future development of fluorophore-based fiber optic aptasensors that can potentially be used in a wet environment for online sensing.
Physico-Chemical Properties, Fatty Acids Profile, and Economic Properties of Raspberry (Rubus idaeus L.) Seed Oil, Extracted in Various Ways
Authors: Ispiryan Audrone , Bobinaite Ramune , Urbonaviciene Dalia , Sermuksnyte-Alesiuniene Kristina , Viskelis Pranas , Miceikiene Astrida , Viskelis Jonas
Published: July 2023

In Europe, the green course is becoming increasingly relevant, and there are more and more suggestions for its improvement. The valorization of food waste attracts increasing attention and is one important current research area. The aim of this study was to examine oils from 16 raspberry variety seeds and to compare their yields and fatty acid contents. The next task was to extract oil from the raspberry variety ‘Polka’ by four different methods and to compare the yield, colors, fatty acids content and composition, and kinematic and dynamic viscosity. The last task was to analyze the economic profitability of oil extraction by different methods. This study demonstrates the potential of different varieties of raspberry by-products and shows the influence of different oil extraction methods on the fatty acid composition of the oil and the economic potential of such products. The analysis revealed that the predominating fatty acid in the raspberry variety ‘Polka’ seed oil was linoleic acid (44.0–44.8%), followed by α-linolenic acid (37.9–38.1%) and oleic acid (10.2–10.6%). Of the 16 raspberry cultivars tested, ‘Polka’ seed oil had the least linoleic (ω-6) (44.79%) and the most α-linolenic (ω-3) fatty acids and the best ratio of ω-6 to ω-3 fatty acids—1.2:1. Raspberry variety ‘Polka’ seed oil contains a lot of carotenoids; their total amount depending on the extraction method varies from 0.81 mg/100 g (extracted with subcritical CO2) to 3.25 mg/100 g (extracted with supercritical CO2). The oil yield can be increased by grinding the seeds into a finer fraction. The most expensive method of oil production is supercritical CO2 extraction, and the cheapest method with the fastest payback of equipment is the cold-pressing method. The results of the research have revealed the influence of different oil recovery methods on the yield of oil, the composition of the fatty acid, colors, and viscosity. The results are very important for producers wishing to commercialize raspberry seed oil.
Transcriptional Profiling Reveals the Wheat Defences against Fusarium Head Blight Disease Regulated by a NAC Transcription Factor
Authors: Vranić Monika , Perochon Alexandre , Doohan Fiona M.
Published: July 2023

The wheat NAC transcription factor TaNACL-D1 enhances resistance to the economically devastating Fusarium head blight (FHB) disease. The objective of this study was to decipher the alterations in gene expression, pathways and biological processes that led to enhanced resistance as a result of the constitutive expression of TaNACL-D1 in wheat. Transcriptomic analysis was used to determine the genes and processes enhanced in wheat due to TaNACL-D1 overexpression, both in the presence and absence of the causal agent of FHB, Fusarium graminearum (0- and 1-day post-treatment). The overexpression of TaNACL-D1 resulted in more pronounced transcriptional reprogramming as a response to fungal infection, leading to the enhanced expression of genes involved in detoxification, immune responses, secondary metabolism, hormone biosynthesis, and signalling. The regulation and response to JA and ABA were differentially regulated between the OE and the WT. Furthermore, the results suggest that the OE may more efficiently: (i) regulate the oxidative burst; (ii) modulate cell death; and (iii) induce both the phenylpropanoid pathway and lignin synthesis. Thus, this study provides insights into the mode of action and downstream target pathways for this novel NAC transcription factor, further validating its potential as a gene to enhance FHB resistance in wheat.
Differences in the Suitable Distribution Area between Northern and Southern China Landscape Plants
Authors: Wang Chen , Sheng Qianqian , Zhao Runan , Zhu Zunling
Published: July 2023

Climate change, a global biodiversity threat, largely influences the geographical distribution patterns of species. China is abundant in woody landscape plants. However, studies on the differences in the adaptive changes of plants under climate change between northern and southern China are unavailable. Therefore, herein, the MaxEnt model was used to predict changes in the suitable distribution area (SDA) and dominant environmental variables of 29 tree species under two climate change scenarios, the shared socioeconomic pathways (SSPs) 126 and 585, based on 29 woody plant species and 20 environmental variables in northern and southern China to assess the differences in the adaptive changes of plants between the two under climate change. Temperature factors dominated the SDA distribution of both northern and southern plants. Southern plants are often dominated by one climatic factor, whereas northern plants are influenced by a combination of climatic factors. Northern plants are under greater pressure from SDA change than southern plants, and their SDA shrinkage tendency is significantly higher. However, no significant difference was observed between northern and southern plants in SDA expansion, mean SDA elevation, and latitudinal change in the SDA mass center. Future climate change will drive northern and southern plants to migrate to higher latitudes rather than to higher elevations. Therefore, future climate change has varying effects on plant SDAs within China. The climate change intensity will drive northern landscape plants to experience greater SDA-change-related pressure than southern landscape plants. Therefore, northern landscape plants must be heavily monitored and protected.
Comparative Analysis of Carotenoid Profiles and Biosynthetic Gene Expressions among Ten Plum Cultivars
Authors: Deng Honghong , Long Xingyu , Wang Xi , Wang Yang , Pang Changqing , Xia Hui , Liang Dong , Zhang Huifen , Luo Xian , Wang Jin , Lv Xiulan , Deng Qunxian
Published: July 2023

Plums are good sources of various bioactive phytochemical compounds such as vitamins, anthocyanins, and carotenoids, whereby all of which are noted for multiple potential health benefits. However, knowledge regarding plum carotenoid profiles remains limited. Hence, the total and individual carotenoids in the edible parts (skin and flesh) of ten plum cultivars were determined using a spectrophotometer and high-performance liquid chromatography–diode array detection, respectively. Total and individual carotenoid contents in skin were significantly higher (p < 0.05) than those in flesh among all plum cultivars tested. The cultivars with the highest content of total carotenoids in skin were Naili (36.73 μg/g FW), followed by Yinhongli (21.81 μg/g FW) and Yuhuangli (19.70 μg/g FW), with the lowest in Angeleno (8.97 μg/g FW). Lutein, zeaxanthine, β-cryptoxanthin, α-carotene, and β-carotene were the major types of carotenoids detected, with lutein and β-carotene being the predominant constituents of the skin and flesh tissues, respectively. Lutein, zeaxanthine, and total carotenoid contents were positively correlated with the expressions of PSY, LCYB, and LCYE, and negatively correlated with the expressions of PDS and CRTISO. Characterizing the carotenoid profiles and investigating variations in carotenoid biosynthetic gene expressions among plum cultivars are crucial for advancing genetic improvements in plums.
Analysis and Description of Key Technologies of Intelligent Energy System Integrated with Source-Grid-Load-Storage in the Oil Field
Authors: Shu Huawen , Ni Chengbo , Wang Lina , Yan Chuan , Sun Dong , Li Wei , Wang Fugang , Xu Hongguang , Sheng Qingbo
Published: July 2023

Integration of source, grid, load, and storage is an important measure for energy transformation. However, at present, the oilfield industry lacks mature models and related technologies. Therefore, an oilfield intelligent energy system integrating source, power grid, load, and storage is proposed in this paper. In view of the poor oilfield data quality, abnormal/missing data diagnosis and repair methods are proposed to improve the information accuracy of the intelligent cloud management center. The improved photovoltaic prediction method of conditional generation countermeasure network (CGAN), PV-VSG control of additional control, and flexible load control are put forward to upgrade the intelligent deployment system. The system design and key technologies can provide reference for the construction of new power systems and energy Internet in the future oilfield industry.
The Effect of Urea Pretreatment Combined with Ultrasonic Vibration-Assisted Pelleting on Pellet Solid Density and Durability
Authors: Li Wentao , Sui Jianning , Wang Liming , Song Jindong
Published: July 2023

Pellets, as a clean and renewable energy source, can overcome the shortcomings of high moisture content, expensive transportation costs, and non-uniform sizes for agricultural residues. However, traditional pelleting methods are associated with high energy consumption and severe mold abrasion due to the application of high temperature and pressure. To address these issues while improving pellet solid density and durability, urea pretreatment combined with ultrasonic vibration-assisted (UV-A) pelleting is investigated in the present research. Comparative experiments were initially conducted to verify the feasibility of the approach, followed by a central composite rotatable design (CCRD) to investigate the relative contributions and interactions of tested variables on pellet solid density and durability during pretreatment. The results revealed that combining urea pretreatment with UV-A pelleting could enhance pellet solid density and durability. Urea content, temperature, waste soybean flour (WSF) content, and distilled water significantly impacted pellet solid density, and all variables except distilled water had a significant effect on pellet durability. The optimal conditions were determined and a subsequent experiment was conducted to verify the agreement between experimental data and predicted results. The optimal conditions consisted of 42% distilled water, temperature of 45 °C, 10% urea content, and 12% WSF content resulting in pellet solid density and durability values of 1438.28 kg m−3 and 98.67%, respectively.
Diagenetic Evolution Control on Reservoir Quality of the Oligocene Weizhou Formation in Weixinan Sag of Beibuwan Basin, Northern South China Sea
Authors: Huan Jinlai , Meng Yuanlin , Wu Qilin , Xiao Lihua , Wang Zixuan
Published: July 2023

This study focuses on the diagenetic evolution of the reservoir in the third member of the Oligocene Weizhou Formation (E3w3) in Weinan Sag of Beibuwan Basin, northern South China Sea. Based on the contents and occurrence states of chlorite, illite, kaolinite and quartz cement were described by scanning electron microscopy (SEM), thin section and X-ray diffraction. In the E3w3 reservoir, three different occurrences of chlorite are recognized. These include chlorite coating, leaf-shaped chlorite and tongue-shaped chlorite. Furthermore, three major types of diagenetic kaolinite are observed. These include kaolin crystallization promoted by fluids of meteoric origin, kaolin formed by organic acids and blocky kaolin. In addition, feldspar, by organic acid dissolution, can mainly form kaolinite but also form illite or chlorite in the E3w3 reservoir. Different clay minerals have different effects on reservoir quality, which are controlled by occurrence and diagenetic environment. Compared to the other minerals, chlorite coating has a greater effect on quartz overgrowth. However, If minerals are packed in intergranular pores, they have a negative effect on reservoir quality.
Marine Pollution and Advances in Biomonitoring in Cartagena Bay in the Colombian Caribbean
Authors: Romero-Murillo Patricia , Gallego Jorge , Leignel Vincent
Published: July 2023

Coastal zones sustain extensive biodiversity, support key processes for ocean dynamics, and influence the balance of the global environment. They also provide resources and services to communities, determine their culture, and are the basis for their economic growth. Cartagena Bay in the Colombian Caribbean is the place of the establishment of one of the country’s main cities, which has a great historical and tourist attraction, and it is also the location of the main commercial port and a great variety of industries. Historically, it has been affected by several environmental impacts and intense pollution. This situation has gained the attention of different researchers, so herein is presented a literature review with a systematic approach using RStudio’s bibliometrix on the presence of pollutants and the impact on biodiversity in recent decades, providing a critical analysis of the state of Cartagena Bay and its future needs to ensure its recovery and conservation. In addition, the socioeconomic dynamics related to the environmental state of Cartagena Bay are presented from the framework drivers, pressures, status, impacts, and responses (DPSIR). The update and critical understanding of the sources, fate, and effects of pollution are important not only for the knowledge of the status of this singular ecosystem but also to encourage future research and entrench evidence to support decision makers’ actions. This review highlights that several pollutants that have been detected exceeding sediment quality guidelines, like As, Cd, Hg, and PAH, are also reported to bioaccumulate and cause damage throughout the trophic levels of the coastal environment. In addition, the potential use of sentinel species and biomarkers for their monitoring is discussed. Finally, the factors that cause pollution and threaten the state of the bay continue to exert pressure and impact; thus, there is a call for the further monitoring of this ecosystem and the strengthening of policies and regulations.
Electroretinography, Ocular Ultrasonography, and Phacoemulsification of Bilateral Cataracts in Two Juvenile Loggerhead Sea Turtles (Caretta caretta) of the Mediterranean Region
Authors: Affuso Andrea , Lamagna Barbara , Costanza Dario , Basso Dario , Scarfò Marzia , Di Palma Cristina , Amalfitano Claudia , Meomartino Leonardo , Maffucci Fulvio , Hochscheid Sandra , Vanore Maria
Published: July 2023

Bilateral cataracts were diagnosed in two rescued juvenile, immature loggerhead sea turtles (Caretta caretta), weighing 1.65 and 1.7 kg. Both animals showed vision impairment and difficulty in feeding without assistance. In fact, they did not notice the presence of the food in the tank unless it was brought close to touching the mouth. Ocular ultrasonography and electroretinography showed no lesions of the vitreal body and retinal layer, therefore, both animals were candidates for bilateral cataract surgery. Topical administration of tropicamide + phenylephrine alternating with rocuronium resulted in only minimal mydriasis. Administration of intracameral rocuronium did not improve mydriasis. Phacoemulsification using a one-handed technique was performed bilaterally with a phacoemulsification device (Sovereign, AMO (Abbott Medical Optics®). After surgery, the systemic anti-inflammatory drug (dexamethasone 0.2 mg/kg, IM daily for one week) and antibiotics (enrofloxacin 10 mg/kg IM q 72 h, for 4 weeks; ceftazidime 20 mg/kg IM q 72 h for 3 weeks) were administered. Topical ofloxacin, flurbiprofen and tobramycin/dexamethasone were instilled TID for 4 weeks. Both turtles regained vision in both eyes. Results at a 10-month follow-up were satisfactory. This is the first report of cataracts in turtles rescued in the Mediterranean Sea and the first description of surgical treatment of cataracts in loggerhead turtles so young.
Innovative methods of recruitment through the NIHR Clinical Research Network (CRN) into large-scale pandemic trials in primary care: the PANORAMIC trial experience
Authors: Tonner Emma , Crawshaw Sarah , Dolman Mark , Chambers Emma , Williamson James , Thomas Nicholas , Hobbs Richard , Little Paul , Butler Christopher , Evans Philip
Published: July 2023

Background

In the summer of 2021, after 18 months of the COVID-19 pandemic, there were still no clear evidence-based interventions for COVID-19 infection in the community. Recruiting large numbers at pace was a challenge to urgently generate the evidence needed to inform care within the pandemic.

Aim

To develop efficient, user-friendly recruitment methods to offer large numbers of acutely unwell, infectious people with COVID-19 UK the opportunity to participate in a priority trial and test the clinical and cost-effectiveness of molnupiravir.

Method

PANORAMIC was an adaptive platform clinical trial with participants randomised to either a novel antiviral or usual care. Participants needed to start antiviral medication within 5 days of symptom onset. Innovative methods of identifying positive individuals within general practice were developed, as well as online research procedures for delivery and follow-up, including throughwww.panoramictrial.org.

Results

Novel methods of recruitment were developed in collaboration between the study team and the NIHR Clinical Research Network (CRN), and continually adapted during the study. These included virtual recruitment through the study website combined with GP recruitment via hub and spoke models: this was supported by data, stakeholder, and workforce infrastructure across devolved administration. PANORAMIC was the fastest recruiting study ever delivered by primary care in the NIHR CRN. There were 26 411 participants recruited. Final molnupiravir results will also be presented.

Conclusion

Large-scale, at-pace recruitment supported by the English CRN and equivalent networks across the UK, is achievable in a pandemic situation, producing potentially game-changing results of national and international importance.
GP Evidence: a new website to support evidence-based practice
Authors: Treadwell Julian
Published: July 2023

Background

GPs regularly prescribe lifelong treatments for long-term conditions, supported by clinical guidelines and encouraged by performance measures. However, GPs have a poor understanding of the absolute benefits and harms of these treatments, impairing their ability to engage in genuine shared decision making or optimally manage polypharmacy. There are few easily accessible and understandable sources of this kind of quantitative information.

Aim

To produce a novel website to communicate understandable, usable information to GPs on the benefits and harms of treatments for long-term conditions alongside supporting information about the relevant evidence base.

Method

Participatory co-design/research-by-design methods. A pragmatic evidence collation and curation process with expert and patient involvement.

Results

A new website, gpevidence.org (openly available from launch date, 1 February 2022) has been developed providing evidence on treatments for 12 common long-term conditions. It employs graphic design and ‘content-designed’ textual information within an information architecture mapping to GPs’ practice and mental models. User-testing and preliminary evaluation have shown it successfully communicates complex evidence about the benefits and harms of treatments to GPs in a way that will be usable and useful in practice.

Conclusion

It is possible to communicate quantitative information about the clinical evidence base behind treatments in a way that will be usable in practice and that complements existing clinical guidelines and normative practice. This has the potential to support shared decision making, improve the management of polypharmacy, and increase GPs’ confidence in this area of practice.
Systematic review and meta-analysis investigating nicotine, cotinine, and carbon monoxide exposures in people who both smoke and use nicotine replacement therapy
Authors: Podlasek Anna , Claire Ravinder , Campbell Katarzyna A , Orton Sophie , Thomson Ross , Coleman Tim
Published: July 2023

Background

Smoking is a major international public health problem.

Aim

To determine effects of concurrent smoking and nicotine replacement therapy (NRT) use on reported heaviness of smoking, nicotine (cotinine) body fluid, and exhaled air carbon monoxide (CO) concentrations.

Method

Systematic review and meta-analysis of randomised controlled trials (RCTs) that test interventions permitting concurrent NRT use and smoking, and comparing, within participants, outcomes when smoking with those when smoking and using NRT concurrently.

Results

In total, 29 studies were included in the review. Meta-analysis of nine showed that, compared to when solely smoking, fewer cigarettes were smoked daily when NRT was used (mean difference during concurrent smoking and NRT use, −2.06 CPD [95% confidence interval {CI} = −3.06 to −1.07,P<0.0001]). Meta-analysis of seven studies revealed a non-significant reduction in exhaled CO during concurrent smoking and NRT use (mean difference, −0.58 ppm [95% CI = −2.18 to 1.03,P= 0.48]), but in the three studies that tested NRT ‘preloading’, a similar reduction in exhaled CO was statistically significant (mean difference, −2.54 ppm CO [95% CI = −4.14 to −0.95,P= 0.002]). Overall, 11 studies reported cotinine concentrations, but meta-analysis was not possible due to data reporting heterogeneity; of these, seven reported lower cotinine concentrations with concurrent NRT and smoking, four reported no differences, and none reported higher concentrations.

Conclusion

People who smoke but who also use NRT reported smoking less heavily than when solely smoking, and when NRT was used as ‘preloading’ this reported smoking reduction was biochemically confirmed. There was no evidence concurrent smoking and NRT use resulted in greater nicotine exposure than smoking.
The Idea of Refinement in Hamlet and Arjuna : A Revision
Authors: - Hemanta Bora
Published: July 2023

The idea adopted here may arise some disagreement among readers due to its untouched gap between the cultural, and traditional heritage that these two divergent backgrounds bear. And, in this effort of sketching of the two heroes from two great literary fields, my intention is to highlight the similar aspects they carry in its bosom- fundamentality of human kind, and its culture. A higher and refined spirit in pursuit of human dignity.
A Study on Microfinance and Rural Development with the Initiative of Nationalized Bank Specially SBI in Assam
Authors: - Dilip Chandra Das
Published: July 2023

Variety of micro finance organizations in government as well as non-government sectors exists in India. Leading national financial institutions like, the National Bank for Agriculture and Rural Development (NABARD) the Small Industries Development Bank of India (SIDBI) and the RashtriyaMahila Kosh (RMK) have played a significant role in making micro credit a real movement in India.Most of the organizations tend to operate within a limited geographical area. There are a few exceptions like Professional Assistance for Development Action (PRADAN), International Centre for Entrepreneurship and Career Development (ICECD), Mysore Resettlement and Development Agency (MYRADA), Self Employed Women’s Association (SEWA), which have been successful in replicating their experiences in other parts of the country and act as resource organizations. Also, many organizations have been involved with SHGs is not only providing credit, but for other purposes like watershed, agriculture also. One of the most common practices and approaches is providing credit through self-Help Groups. The approach is to make SHGs the main focal point to channelize all credit to members. Almost, all national funding organizations (NABARD, RMK) as well as other Government organization advocate forming of Self-Help Groups and providing or linking with credit.
PENGARUH KEPEMIMPINAN, LINGKUNGAN KERJA DAN KEPUASAN KERJA TERHADAP KINERJA APARATUR SIPIL NEGARA PADA BADAN KEUANGAN ASET DAERAH KABUPATEN SIDENRENG RAPPANG
Authors: Fatmawati Andi , Djalante Andi , Asri Asri
Published: July 2023

Penelitian ini bertujuan Untuk mengetahui dan menganalisis pengaruh secara parsial kepemimpinan, lingkungan kerja dan kepuasan kerja terhadap kinerja Aparatur Sipil Negara pada Badan Keuangan Aset Daerah Kabupaten Sidenreng Rappang. Untuk mengetahui dan menganalisis pengaruh secara simultan kepemimpinan, lingkungan kerja dan kepuasan kerja terhadap kinerja Aparatur Sipil Negara pada Badan Keuangan Aset Daerah Kabupaten Sidenreng Rappang. Untuk mengetahui dan menganalisis variabel mana yang paling dominan berpengaruh pada kinerja Aparatur Sipil Negara pada Badan Keuangan Aset Daerah Kabupaten Sidenreng Rappang.Penelitian ini menggunakan analisis deskriptif dengan teknik analisa data kuantitatif yang diperoleh dari hasil kuesioner dengan menggunakan analisis regresi linear berganda. Metode pengumpulan data yang digunakan adalah angket/kuesioner dan wawancara.Hasil penelitian menunjukkan bahwa lingkungan Kerja dan Kepuasan Kerja berpengaruh terhadap Kinerja ASN yang berarti bahwa peningkatan Kepemimpinan, Lingkungan Kerja dan Kepuasan Kerja akan mempengaruhi peningkatan Kinerja ASN Badan Keuangan Aset Daerah Kabupaten Sidenreng Rappang sebesar 90,1%
Sibling position as a condition for the formation of some formal and dynamic features of athletes
Authors: Gornov SV , Rakitina OV , Bogun TV
Published: July 2023

An athlete’s performance is a major issue of the elite sports. The current studies are focused on various factors of success, however, the effect of sibling position on the athlete’s personality formation is poorly understood. The study was aimed to assess the correlation of the formal and dynamic features with the resource potential in athletes who played badminton based on their sibling position using the structured interviews; Questionnaire of Formal and Dynamic Properties of Personality by V.M. Rusalov; Perinatal Experience – Resource Potential test by N.P. Kovalenko; correlation analysis. A total of 40 athletes were enrolled (20 boys and 20 girls; average age 14.5 year). In the “eldest or only child” subsample, the athletes’ communicative plasticity negatively correlated with the parameters of sensory and physiological systems (r = –0.50), as well as stress tolerance (r = –0.60). Correlations between the stress tolerance and psychomotor ergicity (r = 0.63), etc., were revealed. The athletes of the “second or later-born child” subsample had higher psychomotor plasticity and a larger resource potential (p < 0.05). The basic perinatal matrix is integrated into the formal and dynamic structure of the athlete’s personality. Thus, athletes of the “second or later-born child” subsample have a higher resource potential. Athletes of the “eldest or only child” subsample show lower psychomotor plasticity, however, they are more tenacious in fulfilling their goals. The areas of concern for the sports psychologist who works with athletes are highlighted in accordance with the results.