bluuebunny/crossref_metadata_2025 huggingface dataset:
Setting priorities in CNF particle size measurement: What is needed vs. what is feasible
Authors: MOON ROBERT J. , HENSDAL CECILIA LAND , BECK STEPHANIE , FALL ANDREAS , COSTA JULIO , Kojima Eiji , Abitbol Tiffany , Raghuwanshi Vikram , Walker Colleen , Batchelor Warren
Published: March 2023

Measuring the size of cellulose nanomaterials can be challenging, especially in the case of branched and entangled cellulose nanofibrils (CNFs). The International Organization for Standardization, Technical Committee 6, Task Group 1—Cellulosic Nanomaterials, is exploring opportunities to develop standard methods for the measurement of CNF particle size and particle size distribution. This paper presents a summary of the available measuring techniques, responses from a survey on the measurement needs of CNF companies and researchers, and outcomes from an international workshop on cellulose nanofibril measurement and standardization. Standardization needs differed among groups, with Japanese companies mostly requiring measurements for product specification and production control, and other companies mostly needing measurements for safety/regulatory purposes and for grade definitions in patents. Among all the companies, average length and width with percentiles (D(10), D(50), D(90)) were the most desired measurands. Workshop participants concurred that defining the location(s) on the CNF at which to measure the width and the length is an urgent and complex question. They also agreed that methods are needed for rapid particle size measurement at the nanoscale. Our recommendation within ISO is to start work to revise the definition of CNFs and develop sample preparation and measurement guidelines. It was also recommended that further research be done to reproducibly prepare hierarchical branched CNF structures and characterize them, develop automated image analysis for hierarchical branched CNF structures, and develop a classification system encompassing measurements at multiple size ranges from micro- to nanoscale to fully characterize and distinguish CNF samples.
Explicitation Strategy in Translating Indonesian Novel into English
Authors: Mahmud Erlina Zulkifli , Sobarna Cece
Published: March 2023

This research article is about the use of translation strategy namely explicitation in the translation of a novel from Indonesian into English. The data source is an Indonesian novel entitled Lelaki Harimau written by Eka Kurniawan and its English translation, Man Tiger as the data source. The translation of a novel from Indonesian into English may not as many as the translation work from English into Indonesian. The novel creates commands and critics regarding its content as well as its language use. It is interesting to see how Indonesian culture reflected in the novel is presented in English through translation. The translator tries to do his best to provide equal information in the target language text as given in the source language text. The uniqueness in the source language text needs a hard work to do in delivering the closest natural equivalent in the target language text. Untranslatability is no longer issue as there are strategies of translation that can be applied, one of them is explicitation.  The explicitation strategy used is the one proposed by Klaudy. Using descriptive qualitative method, this research is aimed at revealing the kind of information being explicitated, the forms of explicitation used, and the semantic information of the words explicitated. The results show that the kind of information is both cultural and non-cultural, and the forms of explicitation identified are all five of them and semantically all the words being explicitated become clearer, specific, and more informative
ZONA DE PROCESSAMENTO DE EXPORTAÇÃO DE CÁCERES, MATO GROSSO: VOZES E INTERESSES DISSONANTES
Authors: Garcia Yung Felipe , Bampi Aumeri Carlos , Franco da Silva Carlos Alberto , Kohler Marisa Regina , Arantes Almir
Published: March 2023

O estudo trata do processo de implantação da Zona de Processamento de Exportação (ZPE) em Cáceres (MT) e possíveis implicações socioeconômicas e ambientais. Foram realizadas entrevistas com membros da sociedade cacerense, de modo a contrapor diferentes racionalidades em tensão: a que privilegia o vetor de acumulação tecnoindustrial e a que defende o vetor tecnoeco(lógico) de valorização da sustentabilidade ambiental e anuncia alternativas socioprodutivas para as comunidades locais. O projeto é cercado de polêmica socioambiental, pois sua efetivação envolve o agronegócio regional, a qualificação de trabalhadores e a hidrovia Paraguai-Paraná, porque sua utilização pode gerar sérios impactos ao rio Paraguai, ao bioma e às populações que vivem do e no Pantanal.
Relationship of the antibody level between male and female SARS-CoV-2 infected patients in Dhaka city
Authors: Chowdhury Indira , Mishu Farzana Akonjee , Tanjilul Haque Syed Mohammad , Chanda Papon Kumar , Mollah Forhadul Hoque
Published: March 2023

Background: The Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) created an emergency situation experienced by the world.

Objective: To compare the antibody status after SARS-CoV-2 infection in male and female patients.

Methods: This cross-sectional study was conducted in the Department of Biochemistry and Molecular Biology, BIRDEM General Hospital, from July, 2020 to June, 2021. A total of 154 patients (age 18 – 70 years) infected by SARS-CoV-2 were enrolled for this study. Among them, 78 were male and 76 were female. The study subjects were non-vaccinated. For this study, serum IgG level was measured by the automated analyser. For statistical analysis, the Mann Whitney U test was done.

Results: the age distribution of male and female patients. The age group of 50-59 years comprised most of the male patients in comparison to the female study group. Patients with hypertension, diabetes mellitus were more prone to SARS-CoV-2 infection in both groups. Here male patients had more positive history of comorbidities than female patients. Mann-Whitney U test was done to analyze the data which revealed presence of significantly higher IgG in female patients. Here, p <0.02 which was fairly statistically significant.

Conclusion: The antibody level of female patients was significantly higher than that of male patients after SARS-CoV-2 infection.

AKMMC J 2022; 13(1) : 32-36
Progressive pseudo-rheumatoid dysplasia -a rare genetic disorder: Case Report
Authors: Chowdhury Md Faizul Islam , Shova Shamima Sharmin , Monami Afia Zahin , Alam Rajibul , Rahman M Ekhlasur
Published: March 2023

Progressive pseudorheumatoid dysplasia (PPRD), also known as spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA), is an autosomal recessive disorder, resulting from mutations in the WNT1-inducible signaling pathway protein 3 (WISP3) gene involving the axial skeleton as well as small peripheral joints. Because of rarity here we present a case of 14-year-old boy, 1st issue of consanguineous parents who was presented with pain & gradual development of contracture in 3rd distal interphalangeal joint of right hand when he was 4-year-old, then gradual involvement of other interphalangeal joints of hands, bilateral wrists, elbows, shoulder, knees &ankles occurred over years with the development of contractures and restricted movement. For last few years, he developed difficulty in walking. Clinically spinal scoliosis and coxa vara was present. Mobility of spines and multiple joints including proximal & distal interphalangeal joints of hands, wrists, elbows, shoulders, knees, ankles were restricted with flexion contractures. The gait of the patient was limping. Radiological evaluation showed osteopenia in X-ray of pelvis with both hip joints and both knee joints. Generalized osteopenia, fusiform swelling in distal interphalangeal joint, flexion deformity in distal interphalangeal joint of middle and ring fingers of both hand was shown in X-ray of both hands. MRI of lumbosacral spine showed dorso-lumbar vertebral bodies dysplastic with anterior wedging producing bullet nose. Superior epiphyseal deformity was also noted in lower dorsal bodies suggestive of spondyloepiphyseal dysplasia of dorso-lumbar spine. Genetic study showed homozygous nonsense variation in exon 5 of the WISP3 gene suggestive pathogenic variant. Finally, he was diagnosed as a case of PPRD and treated with physiotherapy, family counseling, and anti-inflammatory medications.

AKMMC J 2022; 13(1) : 52-55
Primary Distal renal tubular acidosis: case series
Authors: Halder Soma , Ferdous Jannatul , Tajkia Gule , Roy Kuntal , Amin Syed Khairul , Rahman M Ekhlasur , Hanif Mohammad
Published: March 2023

Primary Distal renal tubular acidosis is an infrequent tubular disorder with complex pathophysiology that present with poor growth, skeletal changes and sometimes life-threatening hypokalemia. Here we present two siblings one girl and one boy with a consanguineous parents presented with polyuria, polydipsia, failure to thrive and skeletal deformity. Both cases showed non-anion gap metabolic acidosis with alkaline urine and the younger brother had periodic paralysis due to hypokalemia. After diagnosis and treatment they showed good response with alkali therapy.

AKMMC J 2022; 13(1) : 56-59
Improvement of Mustard-Boro-T. Aman Rice Cropping Pattern Through Replacing Crop Varieties For Tangail Region
Authors: Khan MAH , Naher Q , Hossain MA , Tasmima T , Sarker PK
Published: March 2023

The experiment was conducted at the farmers field of FSRD site Atia, Delduar, Tangail during two consecutive years of 2018-19 and 2019-20 to develop improved cropping pattern Mustard (var. BARI Sarisha-14) - Boro (var. BRRI dhan29) - T.Aman rice (var. BRRI dhan72) and to compare its productivity and profitability against existing cropping pattern Mustard (var. Tori-7)- Boro (var. BRRI dhan29) - T.Aman rice (var. BR 11) through changing varieties of mustard and T.Aman rice with improved management practices. The experiment was laid out in a randomized complete block design with six dispersed replications. The improved management practice produced significantly higher yield in Mustard and T. Aman rice, respectively. The result showed that mean rice equivalent yield of improved cropping pattern was 16.80 t ha-1 which was 24 % higher than existing cropping pattern (13.50 t ha-1). Besides, production efficiency, land use efficiency, harvest index and profitability of improved cropping pattern was higher than farmers’ existing pattern. The mean gross return (Tk. 279720 ha-1) and gross margin (Tk. 104073 ha-1) were higher in improved cropping pattern compared to existing farmer’s pattern with only 7.82% extra cost. The marginal benefit cost ratio (4.05) also indicated the superiority of the improved cropping pattern over the farmers’ existing pattern.
Bangladesh J. Agril. Res. 46(4): 397-406, December 2021
Effects of Integrated Nutrient Management Uptake On Seed Yield of Onion
Authors: Yousuf MN , Brahma S , Khan MAA , Sarker MMA , Datta SK
Published: March 2023

The field experiment was conducted during two successive rabi seasons of 2015-16 and 2016-17 in the research field of BARI, Gazipur, to evalute the effect of integrated nutrient management (INM) on seed yield and nutrient uptake of onion (var. BARI Piaz-1). The experiment was arranged in Randomized Complete Block Design (RCBD) with three replications having eight nutrient management packages following the INM principle. There were significant effects of INM on the seed yield, yield contributing characters and nutrient uptake of onion. The highest seed yield of 1278 and 1287 kg ha-1 was obtained from treatment poultry liter (PL) based trichocompost (TC) @ 3t ha-1 + chemical fertilizers (IPNS basis) and the minimum seed yield (395 kg ha-1 and 441 kg ha-1) in control (native fertility) treatment in 2015-2016 and 2016-2017, respectively. The N uptake by onion crop ranged from 37.1 to 141.5 kg ha-1 and 42.1 to 146.7 kg ha-1, P uptake from 2.9 to 13.5 kg ha-1 and 3.8 to 20.2 kg ha-1, K uptake from 24.5 to 76.7 kg ha-1 and 30.7 to 74.3 kg ha-1 and the S uptake ranged from 5.8 to 14.5 kg ha-1 and 6.1 to 18.8 kg ha-1 in two respective years. Hence, the PL based TC @ 3 t ha-1 + CF (IPNS) could be regarded as the best nutrient management package for achieving higher onion seed production in Grey Terrace Soil of Madhupur Tract (AEZ-28).

Bangladesh J. Agril. Res. 46(4): 417-424, December 2021
Assessment of Inbred Lines of Field Corn for Yield And Yield Attributes Through Line × Tester Method
Authors: Karim ANMS , Talukder ZA , Omy SH , Sultana R , Alam MK
Published: March 2023

A line × tester analysis comprising forty eight test-crosses generated by crossing 24 S3 inbred lines derived from commercial maize hybrid 981 with two testers. Heterosis study of these crosses against two standard checks was evaluated at Bangladesh Agricultural Research Institute, Gazipur during rabi 2015-16. The objectives of the study were to estimate general and specific combining ability effects of the inbred lines and to assess the test cross performance and estimate the amount of standard-heterosis of the hybrids for grain yield and yield related characters. Highly significant genotypic differences were observed indicated wide range of variability present among them. Five lines viz. Line 11, Line 14, Line 17, Line 24 and Line 30 were good general combiner for grain yield and possessed high means. Nine crosses showed (Line 18 × BIL22, Line 23 × BIL22, Line 27 × BIL22, Line 7 × BIL28, Line11 × BIL28, Line14 × BIL28, Line 24 × BIL28, Line 25 × BIL28 and Line 30 × BIL28) significant and positive specific combining ability effect for grain yield. The information on the nature of gene action with respective variety and characters might be used depending on the breeding objectives. These crosses, Line 24× BIL28 (11.40 t/ha), Line 18 × BIL22 (11.30 t/ha) and Line 25 × BIL28 (11.20 t/ha) showed higher yield, could be utilized in maize breeding activities. Estimation of heterosis was carried out using two commercial hybrids BARI Hybrid Maize-9 (BHM-9) and NK-40. The percent heterosis for grain yield varied from -23.39 to 4.6% against BHM-9. Among the 48 crosses, 13 crosses exhibited significant positive heterosis for grain yield.

Bangladesh J. Agril. Res. 46(4): 469-489, December 2021
A Study On Strategic Initiative for Reinvigorating Employee Engagement Among Gen Z
Authors: Jayanthi R. , Mathews Soney
Published: March 2023

Gen Z are already in the workforce today, being a tech savvy Gen, they have bought new perspectives and expectations at the workplace. The objective of this paper is to understand what are the factors that govern engagement of Gen Z at the workplace and to know the correlation of these factors on employee engagement. Literature review is basis for developing the hypothesis of the study. Study of research papers helped in identifying the common factors mentioned in the study, MS Excel was used to analysis the data that was collected. Correlation co-efficient and regression are the statistical tools used. All the factors identified have a positive correlation with organizational performance and employee engagement of Gen Z. Career development and Rewards and recognitions were the two important factors identified. This paper throws light on the policy changes that has to been done to accommodate the young work force who are ready to join but have diverse expectations of the work place, failing which companies may find it difficult to attract, retain and engage Gen Z in the days to come.
Next-generation sequencing analysis of hepatitis C virus resistance–associated substitutions in direct-acting antiviral failure in South Korea
Authors: Kim Kyung-Ah , Lee Sejoon , Park Hye Jung , Jang Eun Sun , Lee Youn Jae , Cho Sung Bum , Kim Young Suk , Kim In Hee , Lee Byung Seok , Chung Woo Jin , Ahn Sang Hoon , Kim Seungtaek , Jeong Sook Hyang
Published: March 2023

Background/Aims: We used next-generation sequencing (NGS) to analyze resistance-associated substitutions (RASs) and retreatment outcomes in patients with chronic hepatitis C virus (HCV) infection who failed direct-acting antiviral agent (DAA) treatment in South Korea.Methods: Using prospectively collected data from the Korean HCV cohort study, we recruited 36 patients who failed DAA treatment in 10 centers between 2007 and 2020; 29 blood samples were available from 24 patients. RASs were analyzed using NGS.Results: RASs were analyzed for 13 patients with genotype 1b, 10 with genotype 2, and one with genotype 3a. The unsuccessful DAA regimens were daclatasvir+asunaprevir (n=11), sofosbuvir+ribavirin (n=9), ledipasvir/sofosbuvir (n=3), and glecaprevir/pibrentasvir (n=1). In the patients with genotype 1b, NS3, NS5A, and NS5B RASs were detected in eight, seven, and seven of 10 patients at baseline and in four, six, and two of six patients after DAA failure, respectively. Among the 10 patients with genotype 2, the only baseline RAS was NS3 Y56F, which was detected in one patient. NS5A F28C was detected after DAA failure in a patient with genotype 2 infection who was erroneously treated with daclatasvir+asunaprevir. After retreatment, 16 patients had a 100% sustained virological response rate.Conclusions: NS3 and NS5A RASs were commonly present at baseline, and there was an increasing trend of NS5A RASs after failed DAA treatment in genotype 1b. However, RASs were rarely present in patients with genotype 2 who were treated with sofosbuvir+ribavirin. Despite baseline or treatment-emergent RASs, retreatment with pan-genotypic DAA was highly successful in Korea, so we encourage active retreatment after unsuccessful DAA treatment.
First description of Vibrio harveyi as the causative agent of morbidity and mortality in farmed flathead grey mullet Mugil cephalus
Authors: Strem RI , Ehrlich R , Shashar N , Sharon G
Published: March 2023

Flathead grey mullet Mugil cephalus is an important species in the aquaculture industry in the Mediterranean basin and throughout the world. During the last 10 yr, M. cephalus breeding stocks, larvae, and juveniles cultured in Eilat (Israel) have shown neurological signs such as uncoordinated circular swimming, while also presenting oral hemorrhages. Death follows days after the onset of the clinical signs, and mortality rates may reach 80% in some cases, causing high economical losses. Bacteriology isolations from different organs, including the brain, and a Koch’s postulate experiment, confirmed Vibrio harveyi as the causative agent. Histological analyses showed the presence of the bacterium in different organs. However, in the brain, the bacterium was observed only within blood vessels and meninges. In some samples, mild to severe brain tissue damage was seen. In order to understand the virulence and lethality of V. harveyi, a median lethal dose was calculated, and the result was 106 colony-forming units fish-1. To the best of our knowledge, this is the first report that describes V. harveyi isolated from the brain of M. cephalus and validates it as an etiological agent causing neurological signs in this fish species.
Cervical Carcinoma: Current Role of Laparoscopy
Authors: Rimbach Stefan
Published: March 2023

This review aims to analyse and describe the current role of laparoscopy in the treatment of cervical cancer. Laparoscopy has become an important tool in gynaecological oncology. Its general advantages in comparison with open surgery apply to oncological patients as much as they do to benign conditions. Data from retrospective and case-control studies have proven that treatment of early cervical carcinoma is successfully feasible by means of minimally invasive surgery with no compromise of oncological principles nor radicality. Thus, laparoscopy has entered guideline recommendations as an alternative to open procedures when operative therapy is indicated. Nevertheless, laparoscopic radical hysterectomy, as well as lymphadenectomy, remain demanding and require surgeons experienced in both operative oncology and endoscopy.
Cardiac Arrest in Labour Leading to Perimortem Caesarean Section in a Woman With a Body Mass Index >46 With a Successful Outcome
Authors: Farrakh Saadia , Bircher Charles , Khalil Haroona
Published: March 2023

A 42-year-old primigravida was admitted to the delivery suite for induction of labour at term due to gestational diabetes and pre-eclampsia. Her booking body mass index was 46 and she had known, well-controlled asthma. Active labour was established. When she was 8–9 cm dilated, she required fetal blood sampling. At the end of the procedure, the patient had a sudden cardiac arrest. High-flow oxygen at the rate of 15 litres was started with bag and mask and immediate maternal cardiopulmonary resuscitation (CPR) was commenced. After 3 minutes of CPR, a decision was made to perform a perimortem caesarean section to aid effective resuscitation. The baby was delivered swiftly. The patient began to respond and showed signs of life. The patient was transferred to theatre for suturing. The massive postpartum haemorrhage protocol was initiated. The patient was transfused with three units of packed red blood cells, three units of fresh frozen plasma, and two units of platelets. The total blood loss was about 3.5 litres. She recovered in an intensive therapy unit. After 72 hours, her clinical assessment excluded any neurological or other ongoing morbidity. Amniotic fluid embolism was suspected as the cause for cardiac arrest. As the patient made a very quick postoperative recovery, a bronchial lavage was thought to be clinically unnecessary. The baby, initially admitted to the baby unit, was also discharged on Day 3 of life with no morbidity. Both mother and baby were completely well at a 3-month postnatal follow-up visit.
Monozygotic Pregnancies Following Assisted Reproductive Technology: A Review
Authors: Mascarenhas Mariano , Gnanaprabha Keerthi
Published: March 2023

Introduction: Assisted reproductive technology (ART) is associated with an increased risk of monozygotic twinning. This narrative review attempts to summarise the known literature regarding the aetiology, incidence, risk factors, diagnosis, and prognosis of monozygotic twinning following ART.

Aetiology: Monozygotic twinning is caused by the splitting of the early embryo during the peri-implantation phase. According to the classical hypothesis, the timing of the split determines the chorionicity and amnionicity, however this has been questioned in recent literature.

Incidence and risk factors: The incidence of monozygotic twinning in natural conception appears to be independent of extrinsic factors such as ethnicity and age. The incidence of monozygotic twinning is increased from 0.4% of natural conceptions to around 0.9–2.24% of pregnancies following ART. The available literature supports a role of ovarian stimulation and extended culture to the blastocyst stage in increasing the risk of monozygotic twinning. The impact of maternal age and micromanipulation techniques such as assisted hatching and intra-cytoplasmic sperm injection appear to depend on the stage of the embryo being transferred leading to significant heterogeneity between studies.

Diagnosis: The gold standard for diagnosing monozygotic twinning is genetic testing but its cost precludes it from routine widespread use. Most epidemiological studies utilise statistical estimates such as Weinberg’s differential rule and tailored questionnaires. Most studies from ART units have utilised transvaginal sonography for counting the number of gestational sacs or assessing the chorionicity.

Prognosis: The prognosis of twins appears to be dependent on the chorionicity and amnionicity and is largely independent of the zygosity.
Kamu Malı Deneylerinde Geribildirim Tipleri ve Ceza Davranışı
Authors: ÖNEŞ Umut
Published: March 2023

Davranışsal iktisat yazınında, kamu mallarının merkezi otorite olmaksızın sağlanmasını modelleyen gönüllü katılım mekanizması deneylerinde, deneklere cezalandırma olanağı sunulmasının hem katkı düzeylerinin hem de kazanç miktarlarının oturum sonuna kadar yüksek seviyede seyretmesini sağladığı gösterilmiştir. Bu çalışmada, deney tasarımına deneylerin standart iktisadi kurama göre dominant stratejilerini değiştirmeyecek şekilde grup davranışına dair farklı veya ilave geribildirimler sunulmasının ceza ve katkı davranışına etkisi incelenmiştir. Deneklere, ceza aşamasında gruptaki diğer deneklerin katkı miktarları yerine ceza öncesi kazanç miktarları gösterildiği tretmanda, grup kazancının anlamlı bir şekilde arttığı, bunun yanında verilen normal ve anti-sosyal ceza miktarında anlamlı bir düşüş olduğu gözlenmiştir. Ayrıca bu tretmanda, deneklerin bedavacıları daha şiddetli bir şekilde cezalandırdığı ve grup içi katkı miktarının daha homojen olduğu bulunmuştur. Deneklere ceza aşaması sonrası gruptaki diğer deneklerin aldığı ceza miktarlarının da gösterildiği tretmanda ise verilen normal ve anti-sosyal ceza miktarlarında kontrole göre anlamlı bir fark gözlenmezken, bedavacıların cezalandırma şiddeti ve kazanç düzeylerinin anlamlı şekilde daha yüksek olduğu görülmüştür.
In the Nightmare Country: John Metcalfe’s ‘The Bad Lands’
Authors: Freeman Nick
Published: March 2023

‘In the Nightmare Country’ offers a detailed analysis of John Metcalfe’s short story, ‘The Bad Lands’ (1920), arguing that it represents an amalgam of Gothic and modernist devices and preoccupations that has significant implications for the development of twentieth-century British Gothic writing. The article considers how Metcalfe's story was shaped by Joseph Conrad and D. H. Lawrence on one hand and Freudian psychoanalysis and wartime experiences on the other. It also examines the important role played by the anthologist, Dorothy L. Sayers, in the popularisation of emerging forms of psychological gothic during the 1930s.
MERAWAT NILAI TRADISI KE-NU-AN PADA SISWA MELALUI MATA PELAJARAN ASWAJA
Authors: Muliatama Elfa
Published: March 2023

This study aims to determine how the existence of Aswaja subjects in preserving the traditional values ​​of the NU's in MAN Tambakberas Jombang. The existence of aswaja subjects referred to here is the existence of aswaja subjects which are carried out consciously, directed and continuously to introduce and instill Aswaja and NU's religious understanding to students, so that they know, believe and practice them in the sense of making them a life guide. personal, social, national and state. This research is a qualitative research. The subjects of this study were the Aswaja teachers and the students of MAN Tambakberas Jombang. The object of this research is Aswaja and NU's education which is carried out through guidance, teaching, training, and  learning experiences. Data collection techniques in this study are observation, interviews, and documentation. The data analysis used in this research is descriptive qualitative data analysis.

Keywords: Existence of Aswaja subjects, Preserving the values ​​of the NU's tradition

 

Abstrak

Penelitian ini bertujuan untuk mengetahui bagaimana eksistensi mata pelajaran aswaja dalam melestarikan nilai-nilai tradisi ke-NU-an di MAN Tambakberas Jombang. Eksistensi mata pelajaran aswaja yang dimaksud disini adalah adanya mata pelajaran aswaja yang dilakukan secara sadar, terarah dan berkesinambungan untuk memperkenalkan dan menanamkan paham keagamaan Aswaja dan Ke-NU-an kepada peserta didik, agar mereka mengetahui, meyakini dan mengamalkannya dalam pengertian menjadikannya sebagai pedoman kehidupan pribadi, bermasyarakat, berbangsa dan bernegara. Penelitian ini merupakan penelitian kualitatif. Subjek penelitian ini adalah guru Aswaja dan para siswa MAN Tambakberas Jombang. Objek penelitian ini adalah pendidikan Aswaja dan ke-NU-an dilakukan melalui kegiatan bimbingan, pengajaran, latihan, serta pengalaman belajar. Teknik pengumpulan data pada penelitian ini yaitu observasi, wawancara, dan dokumentasi. Analisis data yg digunakan dalam penelitian ini yaitu analisis data deskriptif kualitatif.

Kata kunci : Eksistensi, mata pelajaran aswaja, nilai-nilai tradisi ke-NU-an
ORIENTASI MORAL DENGAN PENDEKATAN KEAGAMAAN DALAM SUPERVISI PENDIDIKAN AGAMA ISLAM
Authors: Adabi Husni
Published: March 2023

The objectives of this study are, 1) To explain educational supervision in moral orientation by educators using a religious approach. 2) Explain the importance of moral orientation that must be done by educators to students. 3) To find out the efforts made by educators in increasing the ability and implementation of moral orientation with a religious approach. 4) To find out about the weaknesses of Islamic religious education in Indonesia today so that educators can better anticipate and improve this. 5) To know a comprehensive approach to learning Islamic religious education.

Keywords: Moral Orientation, Religious, Supervision, Teacher, Islamic education.

 

Abstrak

Tujuan dalam penelitian ini adalah, 1) Menjelaskan mengenai supervisi pendidikan dalam orientasi moral yang dilakukan pendidik dengan menggunakan pendekatan keagamaan. 2) Menjelaskan pentingnya orientasi moral yang harus dilakukan pendidik kepada peserta didik. 3) Untuk mengetahui upaya-upaya yang dilakukan pendidik dalam meningkatkan kemampuan dan pelaksanaan orientasi moral dengan pendekatan keagamaan. 4) Untuk mengetahui tentang kelemahan pendidikan agama Islam di Indonesia sekarang ini agar pendidik lebih dapat mensiasati dan memperbaiki hal tersebut. 5) Untuk mengetahui pendekatan pembelajaran pendidikan agama Islam secara komprehensif.

KataKunci: Orientasi Moral, Keagamaan, Supervisi, Guru, Pendidikan Agama Islam.
Pemanfaatan Limbah Kulit Buah Naga (Hylocereus costaricencis) sebagai Identifikasi Formalin/Boraks pada sediaan Makanan di Lingkungan Desa Tengah Pancur Batu
Authors: Faisal Ahmad Purnawarman , Nurpermatasari Adhisty , Wakidi Riza Fahlevi
Published: March 2023

The use of food additives (BTP) in the food production process needs to be jointly monitored, both by producers and by consumers. The impact of its use can be either positive or negative for the community. This community service activity uses the educational socialization method by conducting counseling and demonstrations on how to make a dragon fruit peel formalin spray kit as a simple way to identify formalin in food. The purpose of this community service is to find out whether waste from dragon fruit peel can be used as a test tool for the formalin content of food preparations in food preparations. The results of Community Service obtained a good knowledge category with the achievement of participants' knowledge levels before counseling and demonstration in the less (26.7%) sufficient (40%) and good (33.3) categories, after the extension the results of the category increased significantly, namely less 0 ( 0%), sufficient (13.4%), and good (86.6%).
Efektifitas Cadre Refreshment dalam peningkatan peran kader dalam penanggulangan TBC di Kabupaten Sumenep
Authors: Trisno Zetiawan , Nurhakim Lukman
Published: March 2023

Tuberculosis is a deadly infectious disease caused by the bacterium Mycobacterium tuberculosis. Indonesia is currently in the second-highest position in the world. Efforts to break the chain of TB in the community require capacity building for cadres as the spearhead in finding and assisting people with TB. The involvement of cadres in TB control programs can be realized through the provision of training. The purpose of cadre refreshment training is to provide understanding and skills for cadres in carrying out case-finding activities and treatment assistance for TB patients. The method used in this activity consists of teaching, simulation, field practice, and continuous evaluation. This training was attended by 45 cadres from 18 areas of the YABHYSA SSR intervention health center Sumenep. Cadre participants consist of 85% women and 15% men and most of them are at the productive age of 89%.
Edukasi Optimalisasi Pelaksanaan Pemberian Makanan Tambahan (PMT) di Kelurahan Sei Keledang
Authors: Astani Ameliora Dwi , Sundu Reksi , Fatimah Nurul
Published: March 2023

Abstract : Malnutrition in East Borneo has been in the chronic-acute category. As the capital city of East Borneo, Samarinda has a high prevalence of stunted dan wasted children. Therefore, the government set up a program called Pro-Bebaya. This program supports the health ministry program to reduce malnutrition among children through a supplementary food program (PMT). In Sei Keledang district (part of Samarinda) there are several problems regarding the PMT program, like inadequate infrastructure, decrement of posyandu visits, and limitation in monitoring nutrition status.

Abstrak : Permasalahan gizi di wilayah Kalimantan Timur masuk ke dalam wilayah gizi kronis-akut. Ibukota Kaltim, Kota Samarinda memiliki prevalensi balita pendek dan kurus yang cukup tinggi. Oleh karena itu, dilakukan upaya pengentasan malnutrisi melalui program Pro-Bebaya. Program ini mendukung salah satu program kesehatan, yaitu penyelenggaraan PMT (Pemberian Makanan Tambahan) yang ditujukan pada anak dan balita. Namun, di wilayah Sei Keledang timbul beberapa kendala, antara lain sarana dan prasana yang tidak memadai, penurunan kunjungan posyandu, dan keterbatasan dalam monitoring status gizi.
Pelatihan Pembuatan Jamu Instan Pada Masyarakat Di Desa Kemanisan Kecamatan Curug Serang Sebagai Upaya Peningkatan Kemandirian Ekonomi Keluarga
Authors: Yusransyah Yusransyah , Nurmay Stiani Sofi , Fathiyati Fathiyati , Nurlaela Rachman Sandy , Halimatusyadiah Leni , Endah Endah , Ismiyati Renditya , Harpan Andri , Pertiwi Meila
Published: March 2023

Traditional medicines are ingredients in the form of plant ingredients, animal ingredients, mineral ingredients, galenic preparations, or mixtures of these materials which have been used for generations for treatment and can be applied in accordance with the norms in force in society, while herbal medicine is a Traditional Medicine made in Indonesia. The purpose of this research is to increase understanding of the importance of increasing understanding regarding the processing of instant herbal medicine and raising awareness of the importance of improving skills in the form of training on making good and correct instant herbal medicine in Kemanisan village. The community service method used in this research is in the form of community relations through counseling and health training. The results showed that the knowledge level of the respondents before the training, namely 41,7 %, was in the sufficient category. The respondents' knowledge level after the training was 50% in the good category. Based on the study results, it can be concluded that the respondents' knowledge level before and after counseling and training increased their knowledge. Community service activities through counseling methods can increase respondents' knowledge regarding managing medicinal plants into an instant herbal products with economic value.
UJI AKTIVITAS ANTIBAKTERI NANOPARTIKEL EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R. Forst & G. Forst) TERHADAP BAKTERI Streptococcus mutans
Authors: Fahira Nelsa , Rahayu Yayuk Putri , Nasution Haris Munandar , Nasution M Pandapotan
Published: March 2023

Streptococcus mutans is one of the bacteria that plays an important role in the formation of dental caries. One of the plants known to have antibacterial compounds are matoa leaves (Pometia pinnata J.R. Forst & G. Forst) family Sapindaceae. The objective of this research was to determine the antibacterial activity of matoa leaves ethanolic extract nanoparticles is better than matoa leaves ethanolic extract against S. mutans bacteria. The research method was carried out experimentally. Free variables, namely the concentration of matoa leaf ethanol extract (KEDM 25% ; KEDM 50%; and KEDM 75%) and the concentration of nanoparticles of matoa leaf ethanol extract (KNDM 2.5%; KNDM 5%; and KNDM 7.5%). Bound variables are antibacterial activity of ethanol extract and nanoparticles of matoa leaf ethanol extract against S. mutans bacteria. The nanoparticle size of the extract was characterized using a Particle Size Analyzer (PSA). Test of antibacterial activity of ethanol extract and matoa leaf ethanol extract nanoparticles against S. mutans using the diffusion method to Kirby Bauer. The result of the extract nanoparticle size characterization was 324.97 nm. Zone of Inhibition (ZOI) values of antibacterial ethanol extract of matoa leaves against S. mutans were 12.00 mm (KEDM 25%), 12.50 mm (KEDM 50%), and 12.60 mm (KEDM 75%). The antibacterial ZOI values of matoa leaf ethanol extract nanoparticles against S. mutans were 8.00 mm (KNDM 2.5%), 9.06 mm (KNDM 5%), and 10.10 mm (KNDM 7.5%). The conclusion is that ethanol extract of matoa leaves can be used as extract nanoparticles, where the extract nanoparticle concentration of 7.5% already has the ability of antibacterial activity that is close to the concentration of 25% ethanol extract, so that it can be said that the extract nanoparticle preparation can reduce the dose of a drug even though it is in the resistant category compared to Amoxicillin 25 g with the susceptible category.
Spatio-temporal simulations of bone remodelling using a bone cell population model based on cell availability
Authors: Calvo-Gallego José Luis , Manchado-Morales Pablo , Pivonka Peter , Martínez-Reina Javier
Published: March 2023

Here we developed a spatio-temporal bone remodeling model to simulate the action of Basic Multicelluar Units (BMUs). This model is based on two major extensions of a temporal-only bone cell population model (BCPM). First, the differentiation into mature resorbing osteoclasts and mature forming osteoblasts from their respective precursor cells was modelled as an intermittent process based on precursor cells availability. Second, the interaction between neighbouring BMUs was considered based on a “metabolic cost” argument which warrants that no new BMU will be activated in the neighbourhood of an existing BMU. With the proposed model we have simulated the phases of the remodelling process obtaining average periods similar to those found in the literature: resorption (∼22 days)—reversal (∼8 days)—formation (∼65 days)—quiescence (560–600 days) and an average BMU activation frequency of ∼1.6 BMUs/year/mm3. We further show here that the resorption and formation phases of the BMU become coordinated only by the presence of TGF-β (transforming growth factor β), i.e., a major coupling factor stored in the bone matrix. TGF-β is released through resorption so upregulating osteoclast apoptosis and accumulation of osteoblast precursors, i.e., facilitating the transition from the resorption to the formation phase at a given remodelling site. Finally, we demonstrate that this model can explain targeted bone remodelling as the BMUs are steered towards damaged bone areas in order to commence bone matrix repair.
Biomechanical comparison of anterior axis-atlanto-occipital transarticular fixation and anterior atlantoaxial transarticular fixation after odontoidectomy: A finite element analysis
Authors: Lu Yuzhao , Hang Gai , Feng Yu , Chen Bo , Ma Shenghui , Wang Yang , Xie Tianhao
Published: March 2023

Background: Anterior axis-atlanto-occipital transarticular fixation (AAOF) and anterior atlanto-axial transarticular fixation (AAF) are two common anterior screw fixation techniques after odontoidectomy, but the biomechanical discrepancies between them remain unknown.

Objectives: To investigate the biomechanical properties of craniovertebral junction (CVJ) after odontoidectomy, with AAOF or AAF.

Methods: A validated finite element model of the intact occipital-cervical spine (from occiput to T1) was modified to investigate biomechanical changes, resulting from odontoidectomy, odontoidectomy with AAOF, and odontoidectomy with AAF.

Results: After odontoidectomy, the range of motion (ROM) at C1-C2 increased in all loading directions, and the ROM at the Occiput-C1 elevated by 66.2%, 57.5%, and 41.7% in extension, lateral bending, and torsion, respectively. For fixation models, the ROM at the C1-C2 junction was observably reduced after odontoidectomy with AAOF and odontoidectomy with AAF. In addition, at the Occiput-C1, the ROM of odontoidectomy with AAOF model was notably lower than the normal model in extension (94.9%), flexion (97.6%), lateral bending (91.8%), and torsion (96.4%). But compared with the normal model, in the odontoidectomy with AAF model, the ROM of the Occiput-C1 increased by 52.2%, −0.1%, 92.1%, and 34.2% in extension, lateral bending, and torsion, respectively. Moreover, there were no distinctive differences in the stress at the screw-bone interface or the C2-C3 intervertebral disc between the two fixation systems.

Conclusion: AAOF can maintain CVJ stability at the Occiput-C1 after odontoidectomy, but AAF cannot. Thus, for patients with pre-existing atlanto-occipital joint instability, AAOF is more suitable than AAF in the choice of anterior fixation techniques.
Effect of the uronic acid composition of alginate in alginate/collagen hybrid hydrogel on chondrocyte behavior
Authors: Zheng Guoshuang , Xue Chundong , Cao Fang , Hu Minghui , Li Maoyuan , Xie Hui , Yu Weiting , Zhao Dewei
Published: March 2023

Introduction: Developing a culture system that can effectively maintain chondrocyte phenotype and functionalization is a promising strategy for cartilage repair.

Methods: An alginate/collagen (ALG/COL) hybrid hydrogel using different guluronate/mannuronate acid ratio (G/M ratio) of alginates (a G/M ratio of 64/36 and a G/M ratio of 34/66) with collagen was developed. The effects of G/M ratios on the properties of hydrogels and their effects on the chondrocytes behaviors were evaluated.

Results: The results showed that the mechanical stiffness of the hydrogel was significantly affected by the G/M ratios of alginate. Chondrocytes cultured on Mid-G/M hydrogels exhibited better viability and phenotype preservation. Moreover, RT-qPCR analysis showed that the expression of cartilage-specific genes, including SOX9, COL2, and aggrecan was increased while the expression of RAC and ROCK1 was decreased in chondrocytes cultured on Mid-G/M hydrogels.

Conclusion: These findings demonstrated that Mid-G/M hydrogels provided suitable matrix conditions for cultivating chondrocytes and may be useful in cartilage tissue engineering. More importantly, the results indicated the importance of taking alginate G/M ratios into account when designing alginate-based composite materials for cartilage tissue engineering.
Blimp-1/PRDM1 and Hr3/RORβ specify the blue-sensitive photoreceptor subtype in Drosophila by repressing the hippo pathway
Authors: Bunker Joseph , Bashir Mhamed , Bailey Sydney , Boodram Pamela , Perry Alexis , Delaney Rory , Tsachaki Maria , Sprecher Simon G. , Nelson Erik , Call Gerald B. , Rister Jens
Published: March 2023

During terminal differentiation of the mammalian retina, transcription factors control binary cell fate decisions that generate functionally distinct subtypes of photoreceptor neurons. For instance, Otx2 and RORβ activate the expression of the transcriptional repressor Blimp-1/PRDM1 that represses bipolar interneuron fate and promotes rod photoreceptor fate. Moreover, Otx2 and Crx promote expression of the nuclear receptor Nrl that promotes rod photoreceptor fate and represses cone photoreceptor fate. Mutations in these four transcription factors cause severe eye diseases such as retinitis pigmentosa. Here, we show that a post-mitotic binary fate decision in Drosophila color photoreceptor subtype specification requires ecdysone signaling and involves orthologs of these transcription factors: Drosophila Blimp-1/PRDM1 and Hr3/RORβ promote blue-sensitive (Rh5) photoreceptor fate and repress green-sensitive (Rh6) photoreceptor fate through the transcriptional repression of warts/LATS, the nexus of the phylogenetically conserved Hippo tumor suppressor pathway. Moreover, we identify a novel interaction between Blimp-1 and warts, whereby Blimp-1 represses a warts intronic enhancer in blue-sensitive photoreceptors and thereby gives rise to specific expression of warts in green-sensitive photoreceptors. Together, these results reveal that conserved transcriptional regulators play key roles in terminal cell fate decisions in both the Drosophila and the mammalian retina, and the mechanistic insights further deepen our understanding of how Hippo pathway signaling is repurposed to control photoreceptor fates for Drosophila color vision.
Biogenic metallic nanoparticles as enzyme mimicking agents
Authors: Ngcongco Khanyisile , Krishna Suresh Babu Naidu , Pillay Karen
Published: March 2023

The use of biological systems such as plants, bacteria, and fungi for the synthesis of nanomaterials has emerged to fill the gap in the development of sustainable methods that are non-toxic, pollution-free, environmentally friendly, and economical for synthesizing nanomaterials with potential in biomedicine, biotechnology, environmental science, and engineering. Current research focuses on understanding the characteristics of biogenic nanoparticles as these will form the basis for the biosynthesis of nanoparticles with multiple functions due to the physicochemical properties they possess. This review briefly describes the intrinsic enzymatic mimetic activity of biogenic metallic nanoparticles, the cytotoxic effects of nanoparticles due to their physicochemical properties and the use of capping agents, molecules acting as reducing and stability agents and which aid to alleviate toxicity. The review also summarizes recent green synthetic strategies for metallic nanoparticles.
Perioperative parameters-based prediction model for acute kidney injury in Chinese population following valvular surgery
Authors: Yan Yun , Gong Hairong , Hu Jie , Wu Di , Zheng Ziyu , Wang Lini , Lei Chong
Published: March 2023

Background

Acute kidney injury (AKI) is a relevant complication after cardiac surgery and is associated with significant morbidity and mortality. Existing risk prediction tools have certain limitations and perform poorly in the Chinese population. We aimed to develop prediction models for AKI after valvular cardiac surgery in the Chinese population.

Methods

Models were developed from a retrospective cohort of patients undergoing valve surgery from December 2013 to November 2018. Three models were developed to predict all-stage, or moderate to severe AKI, as diagnosed according to Kidney Disease: Improving Global Outcomes (KDIGO) based on patient characteristics and perioperative variables. Models were developed based on lasso logistics regression (LLR), random forest (RF), and extreme gradient boosting (XGboost). The accuracy was compared among three models and against the previously published reference AKICS score.

Results

A total of 3,392 patients (mean [SD] age, 50.1 [11.3] years; 1787 [52.7%] male) were identified during the study period. The development of AKI was recorded in 50.5% of patients undergoing valve surgery. In the internal validation testing set, the LLR model marginally improved discrimination (C statistic, 0.7; 95% CI, 0.66–0.73) compared with two machine learning models, RF (C statistic, 0.69; 95% CI, 0.65–0.72) and XGBoost (C statistic, 0.66; 95% CI, 0.63–0.70). A better calibration was also found in the LLR, with a greater net benefit, especially for the higher probabilities as indicated in the decision curve analysis. All three newly developed models outperformed the reference AKICS score.

Conclusion

Among the Chinese population undergoing CPB-assisted valvular cardiac surgery, prediction models based on perioperative variables were developed. The LLR model demonstrated the best predictive performance was selected for predicting all-stage AKI after surgery.

Clinical trial registration

Trial registration: Clinicaltrials.gov, NCT04237636.