bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation Between Printing Parameters and Residual Stress in Additive Manufacturing: A Numerical Simulation Approach
Authors: Alzyod Hussein , Ficzere Peter
Published: August 2023

Fused Deposition Modeling (FDM) is a widely used 3D printing technology that can create a diverse range of objects. However, achieving the desired mechanical properties of printed parts can be challenging due to various printing parameters. Residual stress is a critical issue in FDM, which can significantly impact the performance of printed parts. In this study, we used Digimat-AM software to conduct numerical simulations and predict residual stress in Acrylonitrile Butadiene Styrene (ABS) material printed using FDM. We varied six printing parameters, including printing temperature, printing speed, and infill percentage, with four values for each parameter. Our results showed that residual stress was positively correlated with printing temperature, printing speed, and infill percentage, and negatively correlated with layer thickness. Bed temperature did not have a significant effect on residual stress. Finally, using a concentric infill pattern produced the lowest residual stress. The methodology used in this study involved conducting numerical simulations with Digimat-AM software, which allowed us to accurately predict residual stress in FDM-printed ABS parts. The simulations were conducted by systematically varying six printing parameters, with four values for each parameter. The resulting data allowed us to identify correlations between residual stress and printing parameters, and to determine the optimal printing conditions for minimizing residual stress. Our findings contribute to the existing literature by providing insight into the relationship between residual stress and printing parameters in FDM. This information is important for designers and manufacturers who wish to optimize their FDM printing processes for improved part performance. Overall, our study highlights the importance of considering residual stress in FDM printing, and provides valuable information for optimizing the printing process to reduce residual stress in ABS parts.
IFRS 16: INCONSISTENCIES IN THE LIGHT OF ACCOUNTING THEORY AND REGULATORY CONCEPTUAL FRAMEWORK
Authors: Nunes Ricardo da Costa , Nunes André
Published: September 2023

O presente ensaio teórico apresenta uma análise da consistência e coerência, à luz da teoria contábil e da Estrutura Conceitual Regulatória, dos conceitos e procedimentos utilizados na IFRS 16 relativamente ao arrendamento mercantil operacional. O IFRS 16 estabeleceu um tratamento diferenciado entre arrendadores e arrendatários, estabelecendo procedimentos inconsistentes e nomenclaturas ambíguas. Destaca-se a inconsistência decorrente da contabilização da conta classificada como direito de uso de ativo, um ativo intangível na arrendatária, em correspondência com a conta de ativo na arrendadora, quando o bem já foi transferido para a arrendatária. Pela Teoria Contábil, em especial Paton (1922), e pela Estrutura Conceitual Regulatória do IASB, deveria ser uma conta de recebível. Por fim, questiona-se se a teoria tem que se ajustar às normas vigentes ou propor procedimentos alternativos, a partir da análise do IFRS 16.
ISOMORFISMO INSTITUCIONAL, ESTRATÉGIAS, SUSTENTABILIDADE E SUAS RELAÇÕES
Authors: Gomes de Souza VANEIDE
Published: September 2023

A realização da pesquisa possibilitou que verificássemos a importância do estudo das estratégias no campo da sustentabilidade, a partir da influência do isomorfismo institucional, que ocorre nos diversos campos organizacionais. Esta pesquisa bibliográfica, de natureza qualitativa, foi realizada por meio de um levantamento de dados secundários a respeito dos temas  de isomorfismo institucional, estratégias, sustentabilidade e suas relações em textos base de dados do google scholar.  No contexto do isomorfismo dentro dos campos organizacionais é importante destacar que os mecanismos de mudanças institucionais são estratégias usadas nos/pelos campos organizacionais para que outras organizações se adequem aos padrões institucionalizados dentro dele. A necessidade de equalizar as diversas percepções a respeito do desenvolvimento sustentável, visando o bem comum, por meio do crescimento econômico, sem prejudicar o meio ambiente presente e futuro, levou a criação de várias dimensões e indicadores, que regulam as estratégias antrópicas. Uma das formas de promover o desenvolvimento sustentável das instituições é  a criação de  estratégias de sustentabilidade econômica mundial, nacional, regional e local alicerçadas no isomorfismo institucional.
Implementation of Person Center Maternal Care in Midwifery Care Service: Scoping Review
Authors: Nastiti Aryudaningrum  , Hidayat Asri
Published: August 2023

A midwife has the best role and opportunity in providing midwifery care services and promotion of Maternal Child Health (MCH). Midwifery care is conducted by placing women as partners with a holistic understanding, as a good experience for their physical, psychological, emotional, social, cultural, spiritual, and reproductive health. This review aims to observe scientific research related to characteristics as well as perspectives on personcentered maternal care implementation in midwifery care service. Method: This scoping review was conducted by identifying the review questions by using PEOS framework; identifying relevant article based on inclusion and exclusion criteria; searching article by database; selecting article by using PRISMA Flowchart plot. Result: Based on 10 selection article, 7 articles is obtained A score and the 3 other articles get B score. Furthermore, there are 2 obtained themes, namely the importance and the characteristic of PCMC. Conclusion: The importance thing in each midwifery service implements the care based on Person Centered Maternal Care. PCMC characteristic is providing responsive, supportive care of client, conducting good communication, and providing autonomy to client for determining the choice. Midwifery as care providers should make improvement in the services so that client obtains a good experience in every maternal care provided.
Internet-Based Flipbook as A Health Education Medium on The Dangers of Smoking for Teenagers
Authors: Wibowo Marsiana , Mudayana Ahmad Ahid , Priandini Nurulita
Published: August 2023

A strategy to decrease smoking prevalence in Indonesia is to conduct health education. Various health education media have been widely developed and published, but there has not been found a flipbook educational media with the theme of adolescent smoking control this study aimed to identify the effectiveness of internet-based flipbook media in changing adolescents' knowledge and attitudes about the dangers of smoking.  This research is a pre-experimental design of the type one group pretest-posttest. Researchers treated the youth group using an internet-based flipbook on adolescents' knowledge and attitudes. The results obtained that the Wilcoxon test results on the knowledge variable produced a 2-tailed sig value of 0.0 and the pairT-Testest on the attitude variable is 0.000 at a 2-tailed sig value. The flipbook used for this intervention has proven effective in changing adolescents' knowledge and attitudes about the dangers of smoking.
THE ROLE OF TOURISM MANAGEMENT FOR SUSTAINABLE TOURISM DEVELOPMENT IN NATURE RESERVES IN HUNGARY
Authors:   Széchenyi István University, Faculty of Business, Department of Tourism and Hospitality, Győr, Hungary, IVANCSÓNÉ HORVÁTH Zsuzsanna , KUPI Marcell ,   Széchenyi István University, Faculty of Business, Department of Tourism and Hospitality, Győr, Hungary, HAPP Eva ,   Széchenyi István University, Faculty of Business, Department of Tourism and Hospitality, Győr, Hungary
Published: September 2023

The aim of the research is to reveal the opinion of regional professionals involved in the management of sustainable tourism and its three pillars. Through the results of 27 in-depth interviews with decision-makers and NGOs, we have explored the perceptions of the economic, environmental and social factors, both positive and negative, and the importance of each factor. The analysis of the results clearly shows a difference of opinion between decision-makers and NGOs. The negative impacts of tourism were highlighted by respondents, mainly in terms of the impact on the natural and economic environment, however, the positive impacts were more prominent. The research showed that the impacts on social environment were perceived more positively by respondents, and NGOs did not emphasise negative impacts in this category. The study shows that the role of tourism management in nature conservation areas is necessary and important for sustainable tourism development. The research clearly demonstrates that sustainability is an important issue in tourism. The results of the research also show that decision-makers are not familiar with the concept of sustainability, its precise content and their preparation and knowledge are insufficient to make the right decisions on the subject. The research shows that there is a shortage of professionals with expertise in tourism management, which makes it difficult to implement coordinated tourism development in the area under study.
Aggregating Related Fuzzy Defined Diagnostic Parameters of Complexly Structured Objects
Authors: Bagretsov Sergey , Golubev Mikhail , Konovalchik Maxim
Published: September 2023

The paper considers the task of fulfilling the conditions for consecutive aggregation of hierarchically related fuzzy parameters of the research object state. The necessary conditions for correlating fuzzy aggregated performance indicators of overlying and lower hierarchical levels of a complexly structured object (CSO) are determined. The paper shows that the conditions for matching the aggregated parameters of overlying and lower levels formulated in the article are synthesis of authors’ previously obtained results, taking into account clear estimates of the parameters in the case of their fuzzy measurement. Based on applying the generalization principle of L. Zade, methods have been developed for aggregating parameters and assessing the clarity degree of matching their preference relations in the integral indicator of the object state. An example of aggregating hierarchically related fuzzy indicators of the complexly structured object efficiency is given, confirming the validity of the findings made in the article.
Pengembangan Profesionalisme Guru melalui Pelatihan Penulisan dan Publikasi Artikel Ilmiah Guru Mgmp Bahasa Indonesia SMP Kota Magelang
Authors: Firmadani Fifit
Published: August 2023

Salah satu kompetensi yang harus dimiliki oleh seorang guru adalah ia harus memiliki kompetensi professional yang dapat diwujudkan dengan mengembangkan dirinya dalam suatu penelitian. Penelitian ini nantinya dapat bermanfaat bagi khalayak ketika dituangkan sebagai sebuah artikel yang dipublikasikan ke dalam jurnal ilmiah. Permasalahan riil yang terjadi mayoritas para guru belum mempunyai pengetahuan dan pemahaman mengenai penulisan artikel ilmiah dan bagaimana cara untuk mempublikasikannya di jurnal ilmiah nasional terakreditasi. Tim pengabdian masyarakat Universitas Tidar berupaya untuk membantu menyelesaikan permasalahan tersebut melalui pelatihan penulisan artikel ilmiah dan publikasinya di jurnal ilmiah nasional terakreditasi agar dapat meningkatkan pengetahuan, pemahaman, dan keterampilan para guru MGMP Bahasa Indonesia SMP kota Magelang yang merupakan subyek dari kegiatan pelatihan. Metode pelaksanaan pengabdian melalui pelatihan dan workshop. Pelaksanaan pengabdian terdiri dari kegiatan pengenalan jurnal, pengenalan dan konsep dasar membuat artikel ilmiah, mencari jurnal dengan FGD, dan membuat artikel. Pelaksanaan pengabdian berjalan dengan lancar. Tujuan dari kegiatan dapat tercapai yaitu 1) guru memperoleh pengetahuan baru terkait penulisan artikel ilmiah khususnya dalam menemukan ide dan apa yang perlu tercantum dalam sebuah artikel ilmiah; 2) guru dapat mengakses jurnal nasional terakreditasi dan cara mempublikasikan artikel di jurnal tersebut.
Peningkatan Kompetensi Guru Matematika MTs di Magelang Melalui Pelatihan dan Pendampingan Penelitian Tindakan Kelas
Authors: Franita Yesi
Published: August 2023

Kegiatan pengabdian kepada masyarakat ini dilatarbelakangi adanya permasalahan mitra, yaitu kurangnya pemahaman dan kompetensi guru dalam merencanakan, melaksanakan, dan melaporkan Penelitian Tindakan Kelas (PTK). Program kemitraan masyarakat ini bertujuan untuk meningkatkan pemahaman dan kompetensi guru dalam melaksanakan Penelitian Tindakan Kelas (PTK) dan menulis hasil penelitian dalam bentuk laporan PTK atau artikel ilmiah, melalui pelatihan dan pendampingan PTK. Pelatihan dilaksanakan dengan metode ceramah, tanya jawab, diskusi, praktik penyusunan PTK, dan pendampingan. Kegiatan pengabdian masyarakat ini dilaksanakan melalui tiga tahap, yaitu persiapan, pelaksanaan, dan evaluasi. Instrumen yang digunakan untuk mengukur pemahaman peserta terkait PTK berupa soal pretest dan posttest. Luaran yang dicapai dalam program kemitraan masyarakat ini adalah peningkatan kompetensi dan keterampilan guru-guru Matematika MTs di Magelang dalam menyusun PTK yang terwujud dalam keterampilan merencanakan, menyusun, dan melaporkan penelitian tindakan kelas dalam suatu karya ilmiah PTK, serta terdapat peningkatan pemahaman peserta terkait PTK yang ditandai dengan peningkatan rata-rata hasil posttest dari rata-rata hasil pretest, yaitu dari 48,26 meningkat menjadi sebesar 73,48. Selain itu, dihasilkan juga handout pelatihan PTK, proposal atau artikel PTK, dan publikasi hasil pengabdian pada media massa dalam bentuk elektronik, serta dihasilkannya poster pengabdian.
Las cosas y las prácticas sociales genocidas
Authors: Ataliva Víctor , Molina Luciano Rodrigo , Gerónimo Aldo , Zurita Ruy Diego
Published: August 2023

El análisis de las prácticas sociales genocidas en Argentina posibilita reflexionar sobre la relevancia de ciertas cosas para reconstruir las dinámicas de los propios objetos –asociados o no de manera directa a las víctimas– y del exterminio diseñado por los perpetradores. El análisis de las prácticas sociales genocidas en la provincia de Tucumán (Argentina) posibilita reflexionar sobre la relevancia de ciertas cosas –asociadas o no de manera directa a las víctimas– para reconstruir sus propias dinámicas y del exterminio diseñado por los perpetradores. A partir de un conjunto particular de cosas recuperadas en una intervención forense, nos proponemos una aproximación a la trayectoria histórica de una estructura de fines de siglo XIX transformada, casi un siglo después, en un depósito masivo donde se identificaron a víctimas de la desaparición forzada correspondientes al período comprendido entre 1975 y 1977. Es posible sugerir que la cultura material se comporta como diacrítica cuando no se dispone de testimonios directos (porque no hay sobrevivientes y/o testigos –o éstos aun no declararon) o cuando por las consecuencias de los procesos antrópicos y/o naturales que afectaron los contextos forenses solo es posible una aproximación a los hechos traumáticos del pasado desde las cosas.
Barbed Suture versus Conventional Suture for Uterine Repair in Women with Placenta Accreta and Placenta Increta: A Retrospective Cohort Study
Authors: Dong Ruihong , Zhang Lin , Chen Qian , Chen Qiuhe , Wu Yuxia , Shan Dan , Hu Yayi
Published: September 2023

Background: Placenta accreta spectrum can cause catastrophic hemorrhage. Knotless barbed suture line has been considered to reduce bleeding during cesarean section (CS). The purpose of this study was to determine whether the use of knotless barbed suture line could effectively reduce bleeding in patients with placenta accreta and placenta increta. Methods: After obtaining ethical approval, we performed a retrospective cohort study between women with the barbed suture (n = 42) and no barbed suture (control, n = 42). In the barbed suture group, the bleeding site from the damaged myometrium layer caused by the placenta villous invasion was sutured by barbed line with a continuous running suture made in the myometrium layer. In the control group, the uterine incision was repaired with two layers of a continuous suture using the conventional polyglactin suture line. Primary outcomes were the blood loss during the CS and blood loss in the first 24 hours after surgery. Results: The total sample size was 84 (42 in the barbed suture group, another 42 in the control group). Blood loss during CS was significantly lower than the control group by an average of approximately 200 mL (848.57 ± 373.20 mL in the barbed suture group vs. 1055.95 ± 470.88 mL in the control group, p = 0.028). Blood loss during the first 24 hours was also diminished in the barbed suture group (42.70 ± 36.71 mL in the barbed suture group vs. 65.60 ± 61.44 mL in the control group, p = 0.041). Conclusions: The application of barbed suture line reduced blood loss both during CS and after 24 hours of CS.
A Reappraisal of Lymphadenectomy in Common Gynecological Cancers
Authors: Habib Nassir , Moufawad Graziella , Hayek Jad , Futcher Francoise , Chiantera Vito , Rovira Negre Ramon , Devassy Rajesh , Centini Gabriele , Mereu Liliana
Published: September 2023

Objectives: Lymph node dissection (LND) in gynecological malignancies has always been a cornerstone in the diagnosis of metastasis, it is also considered an important prognostic factor, and a reliable guide to management strategies. However, its incidence of complications, namely lymphedema, vascular injuries and other lesions, has led to a reconsideration of its efficacy and a comparison of the role of systematic vs. sentinel lymph node (SLN) dissection. Mechanism: Review of the literature using keywords such as “lymph nodes”, “sentinel lymph nodes”, “morbidity and mortality”, “gynecological cancers”, “endometrial cancer”, “ovarian cancer”, and “cervical cancer”. Findings in Brief: In the case of endometrial cancer, several studies have investigated the efficacy of SLN compared with systematic LND. Most of the results demonstrated the efficacy of SLN dissection in endometrial cancer, with the added benefit of lower morbidity. In patients with ovarian cancer, the mainstay of treatment is debulking with optimal cytoreductive surgery. Recent studies have compared systematic lymphadenectomy to non-lymphadenectomy, with an additional advantage in the cases of lymphadenectomy. However, since its publication, the lymphadenectomy in ovarian cancers (LIONS) trial, has revolutionized the standard of care for patients with advanced ovarian cancer and has called into question the increased morbidity and mortality in systematic lymphadenectomy. In cervical cancers, lymph node status is considered to be the most important prognostic factor. In this case, limiting lymphadenectomy to the borders of the inferior mesenteric artery seems promising, and studies are currently being carried out to investigate the feasibility of SLN dissection instead of systematic lymph node dissection. Conclusions: SLN dissection is associated with lower morbidity and mortality, and has been shown to be superior to systematic lymphadenectomy in several studies. However, more research and specific guidelines are needed to better select either one or the other method in the management of gynecological cancers.
Correction: Wu et al. Tumor-Suppressor Gene Transmembrane Protein 98 Promotes Proliferation and Inhibits Apoptosis in Ovarian Cancer. Frontiers in Bioscience-Landmark. 2022; 27: 210.
Authors: Wu San-Gang , Xu Jing-Ying , Lei Jian , Hu Min , Zhou Juan
Published: September 2023

The authors wish to make the following corrections to this paper [1]: 1. In the Materials and Methods, Cell Growth Assay section, ‘OD values were determined after 24, 48, 72, and 96 hours to evaluate cell growth’ should instead read ‘OD values were determined after 12, 24, 36, and 48 hours to evaluate cell growth’. And ‘absorbance at 490 nm was obtained by a microplate reader’ should instead read ‘absorbance at 450 nm was obtained by a microplate reader’. 2. We have deleted an input error in Fig. 4A and have replaced it. 3. In Fig 5, in which the images of 0 h in the IOSE80 si-TMEM98 group in Fig. 5C, 6 h in the SKOV3 oe-TMEM98 group, and 12 h in the SKOV3 NC group in Fig. 5E were misused and have been replaced. 4. In Fig 12, we have deleted an input error in Fig. 12 and have replaced it. The authors confirm that the mistakes do not affect the results and conclusions of the study and apologize for any inconvenience caused by this mistake.
An Overview of Heavy Chain Ferritin in Cancer
Authors: Shi Xiaoyan , Zhang Anqi , Lu Jinzhi , Wang Xiaowen , Yi Cunjian , Yang Fuyuan
Published: September 2023

As a spherical protein that acts as a repository for intracellular iron, Ferritin is the most important iron storage form and is known to influence tumor immunity. Unbound ferritin is composed of 24 subunits, made up of ferritin light chain (FTL) and ferritin heavy chain (FTH). Ferritin can be automatically put together to form hollow nanocages that measure 12 nm around the outside and 8 nm around the inside. Cancer causes the second-most deaths worldwide, effective elimination of tumor cells while protecting normal cells is the foundation of modern tumor therapy. To this end, the innate tumor-targeting activity of human FTH1, first identified ten years ago, is highly appealing. Unmodified human FTH1 binds to its receptor, transferrin receptor 1 (TfR1), which is frequently overexpressed in cancer cells. FTH1-TfR1 binding permits improved drug efficacy by promoting ferritin-mediated targeted delivery. In addition, FTH is also associated with the prognosis of multiple typies of cancer. The level of FTH1 is significantly and positively correlated with the infiltration of tumor-associated macrophages. FTH1 also plays an important role in regulating the tumor immunity of solid cancer. As such, FTH1 has been extensively applied in the targeted delivery of anticancer drugs, diagnostic molecules (e.g., radioisotopes and fluorophones), and inorganic nanoparticles (NPs) to tumors.This article reviews the role of FTH in cancer and its potential as a therapeutic target.
Disulfiram/Copper Induce Ferroptosis in Triple-Negative Breast Cancer Cell Line MDA-MB-231
Authors: Chu Meiran , An Xinglan , Fu Cong , Yu Hao , Zhang Daoyu , Li Qi , Man Xiaxia , Dai Xiangpeng , Li Ziyi
Published: September 2023

Background: The complex formed by disulfiram (DSF) and copper (Cu) is safe and effective for the prevention and treatment of triple-negative breast cancer (TNBC). Although previous studies have shown that DSF/Cu induces ferroptosis, the mechanism remains unclear. Methods: The mitochondrial morphology of TNBC treated with DSF/Cu was observed by transmission microscopy, and intracellular levels of iron, lipid reactive oxygen species (ROS), malondialdehyde, and glutathione were evaluated to detect the presence of ferroptosis. Target genes for the DSF/Cu-activated ferroptosis signaling pathway were examined by transcriptome sequencing analysis. Expression of the target gene, HOMX1, was detected by qRT-PCR, immunofluorescence and western blot. Results: The mitochondria of TNBC cells were significantly atrophied following treatment with DSF/Cu for 24 h. Addition of DSF/Cu supplement resulted in significant up-regulation of intracellular iron, lipid ROS and malondialdehyde levels, and significant down-regulation of glutathione levels, all of which are important markers of ferroptosis. Transcriptome analysis confirmed that DSF/Cu activated the ferroptosis signaling pathway and up-regulated several ferroptosis target genes associated with redox regulation, especially heme oxygenase-1 (HMOX-1). Inhibition of ferroptosis by addition of the ROS scavenger N-acetyl-L-cysteine (NAC) significantly increased the viability of DSF/Cu-treated TNBC cells. Conclusions: These results show that DSF/Cu increases lipid peroxidation and causes a sharp increase in HMOX1 activity, thereby inducing TNBC cell death through ferroptosis. DSF/Cu is a promising therapeutic drug for TNBC and could lead to ferroptosis-mediated therapeutic strategies for human cancer.
Analysis of Potential Non-Canonical or Alternate STAT5 Functions in Immune Development and Growth
Authors: Awasthi Nagendra , Ward Alister C. , Liongue Clifford
Published: September 2023

Background: Signal transducer and activator of transcription (STAT) proteins play key roles in development, growth, and homeostasis. These roles have principally been assigned to their “canonical” function as inducible transcriptional activators acting downstream of cytokines and other factors. However, variant “non-canonical” functions have also been identified. The potential in vivo role for non-canonical STAT functions was investigated in the zebrafish model. Methods: Two zebrafish Stat5.1 mutants were generated using CRISPR/Cas9 that should impact canonical functionality: one with a deleted transactivation domain (ΔTAD) and another with a disrupted tyrosine motif (ΔTM). Immune cell development, growth, and adiposity of these Stat5.1 mutants were assessed in comparison to a Stat5.1 knockout (KO) mutant in which both canonical and non-canonical functions were ablated. Results: Both the ΔTAD and ΔTM mutants showed significantly reduced embryonic T lymphopoiesis, similar to the KO mutant. Additionally, adult ΔTAD and ΔTM mutants displayed a decrease in T cell markers in the kidney, but not as severe as the KO, which also showed T cell disruption in the spleen. Severe growth deficiency and increased adiposity were observed in all mutants, but ΔTAD showed a more modest growth defect whereas ΔTM exhibited more profound impacts on both growth and adiposity, suggesting additional gain-of-function activity. Conclusions: These results indicate that canonical Stat5.1 plays a major role in T cell development and growth throughout the lifespan and non-canonical Stat5.1 functions also contribute to aspects of adult T lymphocyte development and growth, with alternate functions impacting growth and adiposity.
RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte Meiosis Pathway in Bone Metastases of Bladder Urothelial Carcinoma
Authors: Liu Yifan , Fan Mingxiang , Xian Shuyuan , Hu Peng , Zhang Mengyi , Zhang Xinkun , Zhang Hao , Zhang Junfang , Dai Lingli , Lin Mingyue , Mei Wangli , Huang Dan , Huang Runzhi , Zhang Jie , Huang Zongqiang
Published: September 2023

Background: Bladder urothelial carcinoma (BLCA) is a malignancy with a high incidence worldwide. One-third of patients may experience aggressive progression later on, and 70% of patients who have undergone surgical intervention will still suffer from metastasis. Materials and Methods: RNA sequencing profiles of BLCA samples were obtained from The Cancer Genome Atlas (TCGA) database. Differential expression and univariate Cox regression analyses were performed to identify prognosis-related differentially expressed immune genes (DEIGs). Subsequently, a proportional hazards model of DEIGs was then constructed by univariate regression analysis. Differential expression and correlation analyses, CIBERSORT, Single Sample Gene Set Enrichment Analysis (ssGSEA), GSVA were conducted on transcription factors (TFs), immune cells/pathways and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The regulation network was then constructed. Eventually, ATAC-seq, ChIP-seq, scRNA-seq, and multiple online databases were employed for further validation. Results: A proportional hazards model of 31 DEIGs was constructed and risk score was calculated and proven to be a independent prognostic factor. Then 5 immune genes were characterized to be significantly correlated with bone metastasis, stage and TF expression simultaneously. 4 TFs were identified to be significantly correlated with prognosis and RBP7 expression. 5 immune cells/pathways were revealed to be significantly correlated with RBP7 expression. Only 1 KEGG pathway was identified to be significant in Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) analyses. The regulatory relationship was then constructed, in which the correlation between EBF1 and RBP7 (R = 0.677, p < 0.001), Th2 cells and RBP7 (R = 0.23, p < 0.001), the oocyte meiosis pathway and RBP7 (R = 0.14, p = 0.042) were the most statistically significant. The results were further confirmed by Assay for Transposase Accessible Chromatin with high-throughput sequencing (ATAC-seq), Chromatin Immunoprecipitation sequencing (ChIP-seq), single-cell RNA sequencing (scRNA-seq), and multiple online databases validation. Conclusions: This study revealed that the EBF1-RBP7 regulatory relationship had potential importance in the bone metastasis in BLCA through Th2 cells and the oocyte meiosis pathway.
Satellite III (1q12) Copy Number Variation in Cultured Human Skin Fibroblasts from Schizophrenic Patients and Healthy Controls
Authors: Ershova Elizaveta S. , Savinova Ekaterina A. , Kameneva Larisa V. , Porokhovnik Lev N. , Veiko Roman V. , Salimova Tatiana A. , Izhevskaya Vera L. , Kutsev Sergei I. , N.Veiko Natalia , Kostyuk Svetlana V.
Published: September 2023

Background: The chromosome 1q12 region harbors the genome’s largest pericentromeric heterochromatin domain that includes tandemly repeated satellite III DNA [SatIII (1)]. Increased SatIII (1) copy numbers have been found in cultured human skin fibroblasts (HSFs) during replicative senescence. The aim of this study was to analyze the variation in SatIII (1) abundance in cultured HSFs at early passages depending on the levels of endogenous and exogenous stress. Methods: We studied 10 HSF cell lines with either high (HSFs from schizophrenic cases, n = 5) or low (HSFs from healthy controls, n = 5) levels of oxidative stress. The levels of endogenous stress were estimated by the amounts of reactive oxygen species, DNA damage markers (8-hydroxy-2′-deoxyguanosine, gamma-H2A histone family member X), pro- and antioxidant proteins (NADPH oxidase 4, superoxide dismutase 1, nuclear factor erythroid 2-related factor 2), and proteins that regulate apoptosis and autophagy (B-cell lymphoma 2 [Bcl-2], Bcl-2-associated X protein, light chain 3). SatIII (1) copy numbers were measured using the nonradioactive quantitative hybridization technique. For comparison, the contents of telomeric and ribosomal RNA gene repeats were determined. RNASATIII (1 and 9) were quantified using quantitative Polymerase Chain Reaction (PCR). Results: Increased SatIII (1) contents in DNA from confluent HSFs were positively correlated with increased oxidative stress. Confluent cell cultivation without medium replacement and heat shock induced a decrease of SatIII (1) in DNA in parallel with a decrease in RNASATIII (1) and an increase in RNASATIII (9). Conclusions: During HSF cultivation, cells with increased SatIII (1) content accumulated in the cell pool under conditions of exaggerated oxidative stress. This fraction of cells decreased after the additional impact of exogenous stress. The process seems to be oscillatory.
Practices, Challenges and Lessons Learned in Selected Lodging Accommodations in Zambales: Basis for Sustainable Operations
Authors: Eusebio-Sison Michelle Van M. , Dellova Rovena I.
Published: September 2023

Adopting sustainability strategies improves a company's efficiency on many levels, including quality of work, a good track record, image improvement, and major investor commitment that affects its operations. This descriptive study aimed to explore the critical viewpoint of the current challenges and lessons learned in selected lodging accommodations in Zambales, Philippines. It employed a sequential explanatory mixed-methods design using purposive sampling with 400 respondents. The Kruskal-Wallis test revealed that there is a significant difference in the perception of the respondents when they are grouped according to job positions. Resort and hotel workforces must be qualified in accordance with their positions, and continuous training is important to inculcate a sense of responsibility. Also, there is a little causal relationship between practices in socio-cultural, economic, and environmental aspects. Employees are not mindful of their practices as to whether they are attributable to sustainable operations. It also reveals that 379 out of 400 resorts and hotels have an existing plan that they are seriously crafting and implementing to address the challenges of their operations. They undertake appropriate measures to ensure that management is responsive to the impacts of tourism. Thus, long-term solutions are stressed to promote the environmental, economic, and social management plans for guest satisfaction and effective overall performance for sustainable lodging accommodations in the region.
Assessment of the Implementation of Plastic and Styrofoam-Free Policy in Baguio City Public Market
Authors: Killip Jr. Alexander G. , Dadulla Myshael Gem P.
Published: September 2023

Plastic waste has been one of the pressing problems in Baguio City. Among the largest contributors to waste is the City's Public Market. The study's main objective is to assess the implementation of the Plastic and Styrofoam-free Policy of Baguio City in its public market to draft an action plan for its possible improvement. Specifically, it sought to determine the level of implementation of the Plastic and Styrofoam-free Policy by the technical working group from the City General Services Office; to determine the level of compliance with the Plastic and Styrofoam-free Policy among the registered stall owners in the public market; and to determine significant difference between the level of compliance among the different groups of registered stall owners in the public market according to their Line of business. The findings shall be a basis for preparing and proposing an action plan. The researchers used a quantitative research design, particularly the descriptive survey research method, and a survey questionnaire as a data collection method. The overall results showed that the ordinance must be implemented and complied with. Given this, the ordinance must be amended, allowing the use of biodegradable plastics as primary packaging for fresh and wet goods. Massive information dissemination thereof will heighten the implementation and compliance therewith.
Health service needs in patients receiving hemodialysis therapy: qualitative study
Authors: Budiyarti Yuliani , Sukanti Evimira
Published: September 2023

Quality health services are health services that are provided based on patient needs, not based on what is owned by the service-providing institution. Patients with chronic diseases such as kidney failure undergoing hemodialysis need more supportive nursing care, such as physical and psychological support and information about their condition. This study aims to explore and identify health service needs in patients receiving hemodialysis therapy. This research is qualitative research on phenomenology. Data was collected using semi-structured and in-depth interviews with 17 participants of end-stage renal failure who underwent hemodialysis therapy, selected by purposive sampling. Thematic analysis is used for data analysis. The study found three main themes: services to meet basic needs when hemodialysis therapy was carried out, support received while undergoing hemodialysis therapy, and Various health services that have yet to be received while undergoing hemodialysis therapy. It can be concluded that identifying service needs positively impacts service quality as healthcare workers will better understand patient expectations. Hemodialysis patients have basic physical, psychological, and support needs. Unmet needs include inadequate drug therapy, health workers, and unmet information needs. Healthcare providers should develop strategies to manage these needs, including physical and psychological modification, improvement of facilities, infrastructure, human resources, and interdisciplinary approaches.
MEMBANGUN MASA DEPAN PENDIDIKAN ISLAM: Belajar dari Sejarah dan Merespon Perubahan Zaman di Era Digital
Authors: Sahlan Mohammad , Iskarim Mochamad
Published: August 2023

Pendidikan Islam memiliki warisan sejarah yang kaya dalam mempersiapkan generasi muslim dengan nilai-nilai agama yang kuat dan pemahaman yang mendalam. Namun, dengan adanya perubahan zaman yang cepat dengan tantangan global, pendidikan Islam perlu beradaptasi agar tetap relevan dengan kebutuhan zaman. Peneliti ini akan mengeksplorasi pendidikan Islam merespon perubahan zaman dengan menggunakan inovasi dan teknologi. Peneliti akan mengidentifikasi sejarah pendidikan islam, tantangan pendidikan islam dan inovasi pendidikan, peran guru dan institusi dalam membangun masa depan pendidikan islam. Metode penelitian yang digunakan adalah deskriptif kualitatif dengan pendekatan studi pustaka, sedangkan sumber data dalam penelitian ini adalah buku-buku refrensi yang berkaitan erat dengan penelitian yang kemudian peneliti kombinasikan dengan Teknik wawancara dengan para ahli dan guru pendidikan guna memperkuat data-data primer yang peneliti dapatkan di lapangan. Hasil penelitian menunjukkan bahwa pemahaman tentang sejarah pendidikan Islam menjadi landasan untuk membangun masa depan yang kuat dan relevan. Penelitian ini juga dapat memberikan rekomendasi praktis kepada para praktisi dan pengambil kebijakan di bidang pendidikan Islam untuk meningkatkan kualitas pendidikan dan memenuhi tuntutan zaman yang terus berubah. Sedangkan implikasinya adalah dapat memberikan gambaran yang utuh kepada para praktisi Pendidikan baik itu guru, para pelaksana dan simpatisan Pendidikan untuk mendapatkan gambaran yang utuh tentang realitas Pendidikan.
Kom se privoleti bloku: jugoslovensko-kubansko rivalstvo u Pokretu nesvrstanih i globalni Hladni rat krajem 1970-ih
Authors: Čavoški Jovan
Published: August 2023

This article tackles the Yugoslav–Cuban rivalry within the Non-Aligned Movement (NAM) which has marked the latter half of the 1970s and it was closely related to the developments in the relationship between the two superpowers during the last phase of détente. This was a conceptual conflict between the two dominant lines within the Movement, one that advocated rapprochement with the Soviet bloc, and it was presented in the face of Cuba and its allies, while the other one, dominated by Yugoslavia and consisted of many other non-aligned countries, strived to preserve the previous non-bloc and independent orientation of this organization. This was an intensive diplomatic struggle which defined the later destiny of the NAM. This article is primarily based on the documents from the Serbian, US, British, Indian, German and Myanmar archives.
Prvi svetski rat u pozorištu: oblikovanje kolektivnog sećanja 1918–1991.
Authors: Tomašević Jasmina I.
Published: August 2023

The First World War has left deep traces on the lives of ordinary people. Therefore, it is no wonder that the theme of war was present in various types of human creativity, among other things in theatre. Considering the complexity of the Yugoslav space, the paper aims to point out the image of war on domestic theatre stages. Using archival material and published sources, we gain insight into different interpretations and representations of war in theatre during the seventy years of the common state. In this way, the theatre contributed to shaping public opinion on the events of 1914–1918.
Comprehensive review of geomechanics of underground hydrogen storage in depleted reservoirs and salt caverns
Authors: Ramesh Kumar Kishan , Honorio Herminio , Chandra Debanjan , Lesueur Martin , Hajibeygi Hadi
Published: August 2023

Hydrogen is a promising energy carrier for a low-carbon future energy system, as it can be stored on a megaton scale (equivalent to TWh of energy) in subsurface reservoirs. However, safe and eﬀicient underground hydrogen storage requires a thorough understanding of the geomechanics of the host rock under fluid pressure fluctuations. In this context, we summarize the current state of knowledge regarding geomechanics relevant to carbon dioxide and natural gas storage in salt caverns and depleted reservoirs. We further elaborate on how this knowledge can be applied to underground hydrogen storage. The primary focus lies on the mechanical response of rocks under cyclic hydrogen injection and production, fault reactivation, the impact of hydrogen on rock properties, and other associated risks and challenges. In addition, we discuss wellbore integrity from the perspective of underground hydrogen storage. The paper provides insights into the history of energy storage, laboratory scale experiments, and analytical and simulation studies at the field scale. We also emphasize the current knowledge gaps and the necessity to enhance our understanding of the geomechanical aspects of hydrogen storage. This involves developing predictive models coupled with laboratory scale and field-scale testing, along with benchmarking methodologies.
Exploring audiovisual speech perception in monolingual and bilingual children in Uzbekistan
Authors: Nematova Shakhlo , Zinszer Benjamin D. , Jasińska Kaja Kinga
Published: September 2023

This study aimed to investigate the development of audiovisual speech perception in monolingual Uzbek and bilingual Uzbek-Russian-speaking children, focusing on the impact of language experience on audiovisual speech perception and the role of visual phonetic (i.e. mouth movements corresponding to phonetic/lexical information) and temporal (i.e. timing of speech signals) cues.Three hundred twenty-one children in Tashkent, Uzbekistan, between the ages of 4 and 10 years discriminated /ba/ and /da/ syllables across three conditions: auditory-only, audiovisual phonetic (i.e., the sound accompanied by mouth movements), and audiovisual temporal (i.e, sound onset/offset accompanied by mouth opening/closing). Effects of modality (audiovisual phonetic, audiovisual temporal, or audio-only cues), age, group (monolingual vs. bilingual), and their interactions were tested using a Bayesian regression model.Participants performed better in the audiovisual phonetic modality compared to the auditory modality. However, no significant difference between monolingual and bilingual children was observed across all modalities. This finding stands in contrast with earlier studies. We attribute the contrasting findings of our study and the existing literature to the cross-linguistic similarity of the language pairs involved. When the languages spoken by bilinguals exhibit substantial linguistic similarity, there may be an increased necessity to disambiguate speech signals, leading to a greater reliance on audiovisual cues. The limited phonological similarity between Uzbek and Russian might have minimized bilinguals’ need to rely on visual speech cues, contributing to the lack of group differences in our study.
Personal values and psychopathology in a diverse youth sample
Authors: España Raul A. , Brandes Cassandra M , Shields Allison , Bates Cheyenne M , Smack Avante J , Tackett Jennifer L
Published: September 2023

Substantial research has examined the associations between youth personality traits and psychopathology, with little attention to the role that personal values might play. Previous work has indicated that youth’s personal values are related to, yet distinct from, personality traits. In adults, personal values are associated with psychopathological constructs such as depression, anxiety, and aggressive/rule-breaking behaviors; however, questions remain about the associations between values and psychopathology in youth, whether values moderate the association between traits and psychopathology, and whether values contribute incremental variance to psychopathology over and above associations with personality traits. The present study sought to answer these questions. Using a diverse sample of 350 children (Mage = 9.81, SD = 0.66 years, 185 girls) and their caregivers, we examined youth self-reported personal values, parent-reported youth personality traits, and parent-reported youth internalizing and externalizing problem behaviors. High hedonism, high power, and low universalism were significantly associated with externalizing psychopathology, and these associations largely did not differ across gender or racial/ethnic groups. Personal values did not moderate established trait-psychopathology associations. Finally, personal values incremented the prediction of externalizing, but not internalizing, psychopathology, beyond personality traits. Collectively, results indicate that youth’s personal values may capture different aspects of psychopathology than personality traits, particularly with externalizing psychopathology. Future studies should incorporate youth personal values for a more comprehensive understanding of the manifestation and development of youth psychopathology.
Efficacy of pre-emptive peripheral nerve block using 0.25% bupivacaine for postoperative analgesia in patients undergoing maxillofacial surgeries under general anesthesia
Authors: Lini Srivastava  , Soumyadip Pal  , Saikat Majumdar  , Soma Chakraborty  , Kaushal Kabir  , Manabendra Sarkar  , Jati Sankar Rudra
Published: September 2023

Background: Conventional analgesia using non-steroidal anti-inflammatory drugs not only provides inadequate pain relief but also can produce a multitude of systemic adverse effects. During oral and maxillofacial surgeries, inhibition of central sensitization by pre-incision nerve blocks with local anesthetic can reduce postoperative pain, may curtail analgesic requirement, and thereby can provide better patient comfort.
Aims and Objectives: This study aimed to evaluate the effectiveness of pre-incisional peripheral nerve block using 0.25% bupivacaine over placebo for postoperative pain relief in patients undergoing oral and maxillofacial surgery under general anesthesia.
Materials and Methods: One hundred and twenty patients of 18–35 years of either sex, American Society of Anesthesiologists physical status class I and II had undergone oral and maxillofacial surgeries were divided into two groups to receive bupivacaine 0.25% (Study group, n=60) normal saline (Control group, n=60) for nerve block before surgical incision. Postoperative pain was assessed by Visual Analog Scale (VAS) score and verbal response scale (VRS) score. The number of rescue analgesia was required in the first 24 h and the incidence of any complications associated with this agent was documented.
Results: The VAS score was found considerably lower in the bupivacaine group compared with the control group in the first 24 h of postoperative period (P<0.05). A similar trend was observed with VRS score in the first 16 h of postoperative period (P<0.05). The number of rescue analgesia required in the control group was much higher in comparison with the study group. There was no serious adverse event in both the groups.
Conclusion: Bupivacaine 0.25% as pre-emptive analgesia can be used to reduce postoperative pain and analgesic requirements in maxillofacial surgeries.