bluuebunny/crossref_metadata_2025 huggingface dataset:
Determination of Aquifer Hydraulic Characteristics from Surface Electrical and Borehole Measurements in Ozoro, Nigeria
Authors: Ofomola M. O. , Otheremu O. P. , Ohwoghere‑asuma O. , Anomohanran O.
Published: September 2022

Surface electrical and borehole measurements were undertaken in order to establish the hydraulic characteristics of alluvial aquifer in Ozoro, Delta State. Ten vertical electrical sounding data were acquired using Schlumberger Configuration. Borehole measurements which included pumping test, well logging and the distribution of grain size analysis were also carried out. The results of the electrical sounding indicate that the aquiferous layer is located between the fourth and fifth layers with resistivity ranged from 53.5 Ωm - 1279 Ωm. The aquifer thickness ranged from 7.67 m - 49.4 m and transmissivity values ranged from 41.4 - 330.5 𝑚2/day. The average hydraulic conductivity (k) value obtained is 6.2 m/day. The borehole lithology, resistivity and spontaneous potential log indicate the subsurface lithology to consists of top soil (brownish), clayey sand, clay, fine sand and gravelly sand. The Cooper Jacob solution was used in the analysis of the borehole pumping experiment and the obtained hydraulic conductivity, transmissivity, storativity and specific capacity are 6.8 m/day, 0.067 m2/min (96.48 𝑚2/day), 25.47 and 0.364 m2/min (524.6 m2/day) respectively. Also, the grain size distribution analysis using the Hazen approximation gave hydraulic conductivity as 11.55 m/day. The results showed that all three methods are applicable for determining aquifer hydraulic parameters.
Improved Electrical Conductivity and Strength of α-Al-Carbon Nanotubes Blended with Silver Nanoparticles Composites
Authors: Aigbodion V. S.
Published: September 2022

An attempt has been made to develop a new enhanced electrical conductor nanocomposites using green synthesis silver nanoparticles (GAgNPs) modified carbon nanotubes (CNTs) reinforced aluminum nanocomposites. High-intensity ball milling and spark plasma sintering (SPS) were used to produce the composites. The nanocomposite' microstructure, strength, model, and electrical conductivity were all determined. 2%GAg.NPs in Al-4-percent CNTs helps to refine the grain structure of the Al-4-percent CNTs. More dislocation density was generated by the creation of sub-grain in the Al-4 percent CNTs+2 percent GAgNPs composite. Tensile strength and electrical conductivity were increased by 82.14 and 106.88% using Al-4-percent CNTs +2%GAg.NPs nanocomposite. The ductility mode of fracture associated with the tiny sub-grain produced at the surface was greatly improved when 2% GAgNPs were added to Al-4% CNTs. It was established that the GAgNPS can been used to coat CNTs enhance the strength and electrical conductivity of Al-4 percent CNTs nanocomposites.
Evaluation of diagnostic utility and performance of rapid SARS-CoV- 2 antigen detection assay in comparison with Real-Time RT-PCR in Kolkata, India
Authors: Saha A. , Ghosh S. , Sen S. , Ghosh S. , Sur T.K.
Published: September 2022

Background: COVID-19 has so far affected millions of people in India. The present study was undertaken to find out the performance and reliability of rapid antigen test (RAT) in compared to reverse transcription polymerase chain reaction (RT-PCR).Methods: The pre and existing medical conditions and clinical signs and symptoms were noted. The nasopharyngeal swab samples were taken for RAT, while both nasopharyngeal and oropharyngeal swab samples were mixed in a sterile viral transported medium (VTM) for RT-PCR. All patients were examined by RAT, while symptomatic negative in RAT were re-examined by RT-PCR.Results: Total 18,965 samples were examined by RAT and 3,998 samples by RT-PCR. Among them, only 5,753 patients (30.3%) were symptomatic and 1,757 patients (9.2%) were symptomatic positive. RAT showed overall 15.2% positive cases. Only 3.7% samples exhibited false negative results in RAT, which were found positive in RT-PCR. Interestingly, Ct (cycle threshold) values were >30 in all these samples.Conclusion: Hence, specific antigen-based rapid diagnostic test (RDT) will be most useful and reliable among any other qualitative tests for screening purpose.
Psychiatric morbidity among adult patients at the medical and surgical emergency departments of a Nigerian teaching hospital
Authors: Mohammed T.A. , Abiodun O.A , Yussuf A.D. , Sulyman D.
Published: September 2022

Objective: The study was conducted to determine the prevalence and pattern of psychiatric morbidity in patients seen at a Nigerian Tertiary Hospital's medical and surgical emergency department.Method: A two-stage cross-sectional descriptive study used a systematic sampling of all consenting patients admitted into the medical and surgical emergency. Six hundred and three patients who met the inclusion criteria and completed a socio-demographic questionnaire and the General Health Questionnaire 12 (GHQ-12) were analyzed. Patients who met the cut-off score of 3 or more on the GHQ-12 and a 20% random sample with GHQ-12 score <3 were further subjected to a definite diagnostic assessment using the Mini International Neuropsychiatry Interview and were diagnosed according to the 10th version of the International Classification of Diseases (ICD-10) criteria.Result: The mean age of respondents was 45±19 years, 63.3% were males, and 71.8% were married. Patients at the medical emergency constituted 53.2%. The weighted prevalence of psychiatric morbidity among medical emergency patients was 21.5% and 17.4% for patients at the surgical emergency. Depressive disorder was the commonest in both wards.Conclusion: Some patients presenting to medical and surgical emergencies have co-existing psychiatric disorders. Conscious efforts should be made to recognize psychiatric disorders among patients with physical illnesses, improving their quality of care and contributing to better outcomes.
Electrocardiographic features in children with severe falciparum malaria at the University College Hospital, Ibadan
Authors: Akinkunmi B.F. , Ogunkunle O.O. , Akinbami F.O. , Orimadegun A.E.
Published: September 2022

Introduction: The high burden of Malaria morbidity and mortality in children is due to its potential to cause multi-organ dysfunction. There is however limited information on the specific electrocardiographic features in falciparum malaria in paediatric age group.Aim: To investigate the electrocardiographic (ECG) features in children with (complicated) severe falciparum malaria (SM) and acute uncomplicated malaria (AUM) at the University College Hospital, Ibadan.Methods: This was a comparative cross-sectional study conducted among 398 children with symptomatic and confirmed Plasmodium falciparum malaria and apparently healthy controls. The frequencies of ECG features were described and compared among these children.Results: The prevalence of ECG abnormality was 79.7% and 63.2% in Severe Malaria SM and Acute uncomplicated malaria AUM patients, respectively. Sinus tachycardia was significantly more frequent in SM than AUM and control groups (p <0.001). The risk of an ECG abnormality was about three times higher in SM than healthy children (p<0.001; OR=2.89;95%CI[1.68,4.99).Conclusion: Severe malaria patients had significant ECG abnormalities (Sinus Tachycardia).
Assessment of dietary energy and protein intake in chronic kidney disease patients: A single centre study.
Authors: Mamven M. , Amira O.
Published: September 2022

Objectives: Nutrition is often neglected as an important management strategy in Chronic Kidney Disease patients and malnutrition is an important determinant of morbidity and mortality. We investigated the energy and protein intake of Nigerian CKD patients and determined the association of energy intake with malnutrition.Methods: A cross-sectional analysis of dietary intake was conducted using 24hour dietary recall and three-day diary records. For malnutrition, anthropometric and biochemistry tests were performed.Results: Mean energy intake was 32.08±4.44 kcalkg-1 d-1 and 38.63±4.01 kcalkg-1 d-1 in CKD patients vs controls respectively (P<.001). The mean protein intake was lower in patients with CKD patients (0.6±0.12 g kg-1 d-1) vs the controls (0.77±0.08 g kg-1 d-1) (P <.001). The energy intake was inadequate in 69% of CKD patients. Inadequate protein intake was observed in 60% of pre-dialysis patients and in 100% of the Haemodialysis patients. Patients with inadequate energy intake were 1.7 times more likely to be malnourished compared to those on an adequate intake (95% CI:1.156- 2.594).Conclusion: We identified low energy and protein intake in our CKD population. Attention should be paid to the nutrition of CKD patients.
Sleep quality and its correlates among adolescents schooling in northcentral Nigeria
Authors: Omotoso A.B.O. , Abdulmalik J.O. , Adediran K.I. , Omigbodun O.O.
Published: September 2022

Objective: Sleep disturbance is common among adolescents around the world. Our study aimed to determine the prevalence of sleeping disorders among in-school adolescents in Ilorin, Nigeria.Methods: With a cross-sectional design, sleep quality was assessed among 512 in-school adolescents using the Pittsburgh Sleep Quality Index (PSQI). A cut-off score of 5 was used. Data analysis was done with the Statistical Package for Social Sciences version 22.Results: Three out of every five adolescents were poor sleepers (PSQI global score > 5). Only a few respondents (19%) had optimal sleep (≥ 9 hours), and more than half had inadequate sleep (< 7 hours). Poor sleep was associated with male gender, being the first born and residence at home. Logistic regression analysis showed that living at home, as against hostel living, was predictive of poor sleep.Conclusion: Most respondents had inadequate sleep. Support from parents and other stakeholders could improve sleep among adolescents, as poor sleep is quite common in this age group. These concerted efforts would promote adolescent mental health in north-central Nigeria.
Determinants of quality of life of patients with uncomplicated diabetes mellitus attending endocrinology clinic, UNIOSUN Teaching Hospital, Osogbo, Osun State
Authors: Afolalu O.O. , Akinwale O.D. , Makinde S.O. , Olawale S.G. , Folami R.O. , Akinbowale B.T. , Kamoru A.A. , Orunmuyi J.I.
Published: September 2022

Introduction: Diabetes Mellitus (DM) is a chronic metabolic disorder that poses significant problems to individuals living with it. The emotional anguish and psychological impact of DM on patients' quality of life (QoL) contribute to poor prognosis of the condition. Therefore, the goal of this study is to examine how psychological experiences and satisfaction with diabetic care affect patients' QoL.Methods: A descriptive research survey conducted among one hundred and ten (110) diabetes patients attending the UNIOSUN Teaching Hospital's endocrinology clinic in Osun State, Nigeria between June and December, 2020. Modified Kessler psychological distress scale and World Health Organization Quality of Life Instrument (WHOQOL-BREF) were used to collect data. Data were analyzed using descriptive statistics of frequencies, percentages and tables, while inferential statistics of chi-square was used to test the stated hypothesis at 0.05 level of significance.Results: The results showed that more than three-fourth of the patients had negative social 83(75.5%) and psychological 79 (71.8%) experiences with diabetic care, though majority 68(61.8%) demonstrated good quality of life. The result also showed a positive relationship between psychological experience and quality of life (x2=9.766; df=1; p-value=0.001) as well as social experiences and quality of life (x2=4.576; df=1; p-value=0.032). More so, socio-demographic characteristics of age, gender, marital status, level of education, occupation and income were significantly associated with quality of life of diabetes patients.Conclusion: Overall quality of life of diabetes patients was observed to be good, although majority of diabetes patient had negative social and psychological experiences. Therefore, efforts to improve diabetic care must be intensified in clinical settings to promote good health outcomes and prevent negative social and psychological impact of diabetes mellitus.
Depression among women with infertility versus pregnant women at General Hospital Ilorin: A comparative analytical study.
Authors: Sulyman D. , Kuranga A.T.
Published: September 2022

Objectives: Infertility is associated with emotional distress because of the pressure placed on the couples, especially women, in sub-Saharan Africa. The study found the prevalence of depression and associated factors among women attending infertility clinics and compared them with pregnant women at antenatal clinics.Methods: The study was a comparative analytical study consisting of 199 respondents with infertility and a control group of 200 pregnant women. General Health Questionnaire 12 was administered to both groups, and respondents that scored 3 points and above were administered the Mini International Neuropsychiatric Interview questionnaire (MINI) to make the diagnosis of depression and data were analysed.Results: The prevalence of depression among the case group was 52.0%, while the control was 9.5%. Factors associated with depression were longer duration of the marriage and women with utero-tubal infertility.Conclusion: Depression is common among women with infertility when compared with pregnant women.
Combined administration of Gegen Yinlian decoctio n and metformin ameliorates liver metabolic disorder in rats by regulating miR 195 5p/IRS1/PI3K/AKT axis
Authors: Zhao Yan , Chen Jie , Xu Yi , Liu Geling , Cui Jia , Liu Liping , Gao Jie
Published: September 2022

Purpose: To investigate the effect of Gegen Yinlian decoction (GYD), made from lobed kudzuvine root, baicalensis, huanglian and liquorice, and metformin on liver metabolism dysfunction in type 2 diabetes mellitus (T2DM) rats.

Methods: Wistar rats were treated with high-fat diet and a single intraperitoneal streptozotocin (STZ) injection to establish T2DM model. Thereafter, the T2DM-rats were treated with GYD and metformin (GYD/metformin). Serum triglyceride (TG), TC, LDL, and HDL levels, as well as glucose and insulin tolerance of the rats were evaluated. Furthermore, the effects of GYD/metformin treatment on the expressions of the related genes were determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunoblot assay.

Results: After GYD-metformin treatment, the metabolic indicators in T2DM rats significantly improved (p < 0.05). However, there was decrease in t liver miR-1955p expressions. Silencing miR-195-5p improved glucose consumption and triglyceride levels of palmitate (PA)-induced pathological state in ALM12 cells (p < 0.05). Furthermore, miR-195-5p targeted insulin receptor substrate 1 (IRS1). Suppression of IRS1 partly annulled the impact of miR-195-5p silencing on ALM12 cell model. Moreover, IRS1 downregulation significantly mitigated the impact of the silencing on PI3K/AKT pathway activity (p < 0.05).

Conclusion: Combination of GYD with metformin ameliorated dysfunctional liver metabolism via control of miR-195-5p/IRS1/PI3K/AKT axis.
Therapeutic effect of percutaneous pedicle screw fixatio n, combined with Tongdu Huoxue decoction on thoracolumbar spine fracture
Authors: Liu Pengfe , Nie Jianbin
Published: September 2022

Purpose: To study the therapeutic effect of percutaneous pedicle screw fixation (PPSF) combined with Tongdu Huoxue decoction on thoracolumbar spine fractures.

Methods: Ninety-eight patients with thoracolumbar spine fractures treated with PPSF were retrospectively enrolled and grouped into a study group (SG, n = 51, PPSF combined with THD), and a control group (CG, n = 47, PPSF). General surgical indices, postoperative pain, postoperative Oswestry dysfunction index (ODI index), preoperative and postoperative imaging indices, and postoperative hemodynamic indices were determined and recorded.

Results: Patients in SG exhibited significantly lower visual analog scale (VAS) scores higher than those of CG at 3, 7 and 15 days after surgery (p < 0.05). At 15 and 30 days after surgery, patients in SG exhibited significantly lower ODI index than those in CG (p < 0.05). At day 60 after surgery, Cobb angle was lower in SG than in CG, while the injured vertebral body showed higher anterior height in SG than in CG. Furthermore, FIB and D-D were lower in SG than in CG at day 7, but exhibited higher PT than CG (p < 0.05).

Conclusion: The combined application of PPSF and THD in patients with thoracolumbar fractures ameliorates postoperative pain levels, improves short-term spinal function, and significantly alters the postoperative coagulation index of patients, presumably by reducing the incidence of postoperative thrombosis. However, there is a need for further clinical trials prior to the introduction of this therapy into clinical practice.
Effects of early lumbar cistern drainage of cerebrospinal fluid and combination of edaravone and nimodipine on vasospasm, intracranial pressure, inflammatory factors in traumatic subarachnoid hemorrhage
Authors: Tong Wenjie , Jiang Yongliang , Huang Bo , Fang Jun
Published: September 2022

Purpose: To investigate the effect of early lumbar cistern drainage (LCD) of cerebrospinal fluid (CSF) and combination of edaravone and nimodipine on vasospasm, intracranial pressure (ICP), serum inflammation, S100 and vascular endothelial growth factor (VEGF) levels in traumatic subarachnoid hemorrhage (tSAH).

Methods: Treatment was administered to 136 patients divided into control group (n = 68) and study group (n = 68). Serum inflammation was determined by assessing the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) while nitric oxide (NO), endothelin-1 (ET-1), S100 and VEGF levels were determined by enzyme-linked immunosorbent assay (ELISA). Serum C-reactive protein (CRP) level was measured by immunoturbidimetry. Perfusion weighted imaging was performed and the mean transit time (MTT), cerebral blood flow (CBF), cerebral blood volume (CBV), mean flow velocity (Vm) and pulsatility index (PI) were recorded. Glasgow coma scale (GCS) score and Montreal cognitive assessment (MoCA) score were used to compare the differences in therapeutic effect.

Results: Compared with values before treatment, Vm, PI, NO, CBF, CBV, GCS score and MoCA score were significantly increased (p < 0.05), while ICP, serum levels of TNF-α, IL-6, CRP, ET-1, S100 and VEGF and MTT significantly decreased (p < 0.05). Therapeutic response rate of the study group (89.71 %) was higher than that of control group (66.18%) (p < 0.05).

Conclusion: Early LCD of CSF and combination of edaravone and nimodipine reduces the degree of cerebral vasospasm and contribute to brain function recovery in the treatment of patients with tSAH. This therapeutic strategy requires further clinical trials before application in clinical practice.
Comparison of gemcitabine/carboplat in versus paclitaxel/cisplatin for the management of non small cell lung cancer
Authors: Wang Wei , Li Wenli , Dai Lili , Zhao Lei , Qu Kaixin
Published: September 2022

Purpose: To determine the comparative efficacy and toxicity of gemcitabine/carboplatin and paclitaxel/cisplatin in patients with completely resected stage IIa - IIIa non-small cell lung cancer (NSCLC).

Methods: Sixty eligible NSCLC patients treated in Funan County People's Hospital were enrolled and assigned to two groups by randomization (n = 30 each). One group (CG group) received the combination of gemcitabine and carboplatin, while the second group (CP group) received a combination of cisplatin and paclitaxel. Efficacy was assessed based on 2-year progression-free survival, while adverse reactions were recorded to assess the toxicity of the chemotherapy treatments.

Results: No marked difference was found in the 2-year relapse-free survival in the two groups with similar clinical baseline characteristics after follow-up (60 % in CG group vs. 56.67 % in CP group, p = 0.826). Specifically, no significant difference was found between the two groups with regard to incidence of local metastases, distant metastases, or brain tissue metastases within 2 years, and there were no treatment-related deaths. CG group was more likely to develop leukopenia (93.33 % vs. 63.33 % for CP group, p = 0.04), but no significant difference was observed for other adverse effects such as anemia, vomiting, and nausea.

Conclusion: This study shows that adjuvant treatment using carboplatin and gemcitabine produces the same therapeutic efficacy as cisplatin and paclitaxel, but exhibits higher toxicity levels than the latter.
Clinical efficacy of combined use of Xuebijing and mild hypothermia therapy for the treatment of severe traumatic brain injury, and its effect on patient mortality and complications
Authors: Zheng Yadong , Chen Peng , Zhang Qingtao , Sun Chao , Xiang Yi , Zhou Weiduo , Xu Yi
Published: September 2022

Purpose: To investigate the clinical efficacy of combined use of Xuebijing and mild hypothermia therapy in severe traumatic brain injury (TBI), and its effect on mortality and incidence of complications.

Methods: Eighty-six severe TBI patients admitted to The Fourth People's Hospital of Chongqing were selected. Patients were randomly and equally assigned to control group (COG) who received conventional treatment, and study group (EXG) given a combination of Xuebijing and mild hypothermia therapy. Relevant clinical indicators and therapeutic effects were compared.

Results: Post-treatment levels of inflammatory indices, including procalcitonin (PCT), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were significantly reduced, with lower levels in EXG (p < 0.05). Between-group differences were seen in human leukocyte antigen-DR isotype (HLA-DR), CD3+, CD4+, CD8+, and C3 indicators (p < 0.05). EXG had significantly lower protein expression levels of neuron-specific enolase (NSE) and S100 beta than COG (p < 0.05). After treatment, plasma protein levels of coagulation indices, viz, prothrombin time (PT) and activated partial thromboplastin time (APTT) were lower than pre-treatment levels, with even much lower levels in EXG (p < 0.05). There were reduced incidence of lung infection, acute gastrointestinal injury, acute respiratory distress syndrome (ARDS) and hypernatremia (p < 0.05). More patients had better recovery in EXG (p < 0.05) than in control group.

Conclusion: The combined therapy improves the prognosis of severe TBI, lowers the levels of inflammatory factors, ameliorates plasma coagulation, and enhances immunity with a high degree of safety. However, further clinical trials should be undertaken prior to application in clinical practice
FMNL1 promotes growth and metastasis of breast cancer by inhibiting BRCA1 via upregulation of HMGA1
Authors: Zhang Qian , Yang Hua , Tang Caiyi , Wang Qian , Ren Lili , Jia Chao , Zou Hui
Published: September 2022

In the earlier published article, “Herbei Province” included in the affiliation of the second author is incorrect. “Chongqing” is a municipality directly under the Central Government and does not belong to "Hebei Province”. At the request of the author, the correct affiliation is provided above. New citation: Zhang Q, Yang H, Tang C, Wang Q, Ren L, Jia C, et al. FMNL1 promotes growth and metastasis of breast cancer by inhibiting BRCA1 via upregulation of HMGA1. Trop J Pharm Res 2021; 20(8):1559-1564 doi: 10.4314/tjpr.v20i8.2. Erratum: 2022; 21(8): 1807 doi: 10.4314/ tjpr.v 21i8.31

Earlier citation: Zhang Q, Yang H, Tang C, Wang Q, Ren L, Jia C, et al. FMNL1 promotes growth and metastasis of breast cancer by inhibiting BRCA1 via upregulation of HMGA1. Trop J Pharm Res 2021; 20(8):1559-1564 doi: 10.4314/tjpr.v20i8.2
Regulation of RhoA/ROCK1 signaling pathway by miR 26b in sepsis induced acute lung injury
Authors: Mao Yi , Gao Yi , Zhao Zhiwei , Zhang Jinbo , Dong Meiping , Cao Liexiang
Published: September 2022

Purpose: To investigate the role of miR-26b in the regulation of RhoA/ ROCK1 signaling pathway in acute lung injury (ALI) caused by sepsis.

Methods: Thirty male rats were randomized into sham group (SG), cecal ligation and puncture (CLP) group (CG) and miR-26b mimic group (MG). Hematoxylin and eosin (H & E) staining assay was performed to determine the pathological characteristics of rat lung tissues in each group, while enzyme-linked immunosorbent assay (ELISA) was conducted to determine TNF-α and IL-1β levels. The miR-26b expression was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR), while RhoA and Rock1 protein levels were assessed using western blotting.

Results: The CG had significant lung injury in comparison with the SG. There were significant elevation in TNF-α and IL-1β levels (p < 0.05). RhoA and ROCK1 levels in lung tissue were noticeably elevated in CG (p < 0.05). After treatment, lung injury in MG was reduced in contrast to CG. The MG showed statistically significant decrease (p < 0.05) in the levels of TNF-α and IL-1β, while the lung tissue mRNA expression and the RhoA and ROCK1 expression levels were significantly reduced in MG (p < 0.05).

Conclusion: The MiR-26b mimics plays an important role in the treatment of ALI induced by sepsis in rats by regulating RhoA/ROCK1 signaling pathway. Thus, the findings of this study provide a theoretical basis for clinical studies on the use of miR-26b in the therapy of sepsis.
Annexin A1 mimetic peptide Ac2 26 alleviates renal inflammatory injury in diabetic mouse model by suppressing p38MAPK/NF κB
Authors: Zhang Kangyi , Teng Xiaochun
Published: September 2022

Purpose: To investigate the protective role of mimetic peptide Ac2-26 of annexin A1 (ANXA1) in regulating p38MAPK/NF-κB for renal inflammatory injury in a diabetic mouse model.

Methods: The mice were divided into three groups (control, model and Ac2-26; n = 8). Control was untreated, normal mice, while Ac2-26 was treated with mimetic peptide Ac2-26 after induction of type I diabetes with streptozotocin (60 mg/kg). The model group was not further treated after induction of diabetes. The fasting blood glucose (FBG), blood lipid, and renal function were evaluated. Serum inflammatory factors in renal tissue were also assessed.

Results: Compared with the model group, there was a significant decrease in the levels of FBG, blood lipids (TG, TC, LDL and ox-LDL), KI, 24 h urinary protein, Cr and BUN, and significant increase in body weight in AC2-26 group (p < 0.001). There was a marked decrease in TNF-α, IL-6, IL-1β, and IL-18 levels, as well as levels of mRNA and protein expressions of p38MAPK, NF-κBP6 and ANXA1 in AC2-26 group when compared with the model group (p < 0.001).

Conclusion: ANXA1 is the target gene of p38MAPK, and mimetic peptide Ac2-26 alleviates renal inflammation by suppressing p38MAPK/NF-κB pathway, thus improving renal function in diabetic mice models. This finding suggests a probable approach to developing an effective treatment for renal inflammation in diabetic renal injury.
Prevalence of microplastics, antibiotic resistant genes and microplastic associated biofilms in estuary - A review
Authors: A Merline Sheela , G Dhinagaran
Published: September 2022

The estuarine ecosystem is under threat due to the addition of different anthropogenic pollutants. Among the various pollutants, microplastics(MPs), and antibiotics play a significant role in affecting estuarine organisms and human health by transport through the food chain. In the estuaries, microorganisms, including pathogens, colonise microplastics by the development of biofilms. Estuaries have long been home to MPs, served as novel hubs for the transmission of Antibiotic Resistance Genes (ARGs). As a result of their continual interactions with a variety of aquatic creatures, MP-associated bacterial communities will eventually present a transfer opportunity to organisms that consume MPs. To comprehend the presence of microplastics and ARGs in the estuaries, a thorough review is necessary. This review discusses the various sources of MPs and antibiotic pollution, as well as the transport of ARGs via biofilm formed on MPs. Furthermore, the factors affecting biofilm formation in estuaries are reviewed. In addition, the transport of ARGs by microbial populations within biofilm is discussed. The ARGs are transported into the food chain, which will be a threat to human health. Hence, the occurrence of antibiotic-resistant genes in fish is discussed.
Perancangan Pengelolaan Data Presensi Sidik Jari Berbasis Web dalam Dunia Pendidikan (Studi Kasus : Institut Shanti Bhuana)
Authors: Purwanti Benecta Ina , Alfianus Paulus , P Noviyanti
Published: September 2022

Saat ini kita lihat didalam proses belajar mengajar banyak sekali kampus yang masih menggunakan presensi secara manual, padahal saat ini dunia sudah sangat canggih kalau dilihat dalam perkembangan teknologinya. Permasalahan yang muncul adalah kenapa kampus-kampus tidak menggunakan presensi secara online, misalkan menggunakan fingerprint berbasis website atau yang biasa kita kenal dengan mesin sidik jari yang bertujuan mencegah kecurangan dalam presensi misalkan terjadi kecurangan dalam presensi kehadiran yang memanfaatkan teman sekelasnya. Dengan menerapkan fingerprint secara online itu akan sangat membantu dalam mencegah terjadinya kecurangan dalam presensi. Dengan adanya fingerprint juga dapat membantu menyelesaikan permasalahan, misalkan adanya mahasiswa yang datang maupun pulang pada jam yang ditetapkan, itu akan kelihatan waktu mahasiswa datang dan pulang. Tidak hanya itu saja, para dosen juga mudah dalam pengambilan data untuk merekap kehadiran mahasiswa. Dan dengan menerapkan presensi kehadiran menggunakan fingerprint ini dapat mempermudah para dosen dalam merekap kehadiran dari setiap mahasiswa.
Decision Support System for Scoring In Informatics Engineering Practicum Assistant With Simple Additive Weighting (Saw) Method Web 2.0 Based
Authors: Hasibuan Liyando Hermawan , Munaji Achmad Arif , Deolika Agatha , Chitayae Nadya , Setiawan Erik
Published: September 2022

Abstract— In this modern era, the assessment of an individual with other individuals is still in the subjective stage, a human being assesses the abilities of other humans by using various points of view. Likewise, what Pratikan did to his Pratikum Assistants gave them an assessment that was in accordance with what they had, but the assessment sometimes had different parameters so that the conclusions between one person and another were different, there was no similarity in judging one person.

With the Simple Additive Weighting (SAW) method, the problem can be solved with the help of this method. Websites that have become part of social life and are closely integrated in daily activities. So using the SAW method, one of the alternatives in the assessment can provide a Pratikum Assistant.

The results obtained from these values ​​can provide a new perspective on various kinds of problems. Deciding that no Practicum Assistant can be reused or the results of a given Assessor can help create a new resolution to the pattern of scoring in Practicum Assistants.
Detection of Color Domination of Image Pieces as a Digital Puzzle Machine
Authors: Himamunanto Agustinus Rudatyo , Haeni B Haeni B
Published: September 2022

Puzzle adalah permainan menata kembali kepingan obyek gambar, yang dapat melatih kreativitas, keteraturan, dan tingkat konsentrasi. Permasalahan dalam permainan puzzle akan semakin rumit saat ukuran kepingan semakin kecil sehingga jumlah kepingan semakin banyak. Tantangannya adalah, bagaimana selalu dapat membuat susunan puzzle baru dan menyusun ulang pemulihan potongan secara cepat. Fokus dalam penelitian ini adalah mengatur potongan puzzle secara random dan berupaya melakukan reposisi puzzle  menggunakan metode usulan  yaitu DCD (Dominan Color Detection). Metode DCD bekerja dengan menggunakan metode color histogram utuk melakukan  pelacakan citra berdasarkan informasi dominan warnanya. Metode Eucledian Distance selanjutnya dipergunakan untuk  mengukur tingkat kemiripan citra . Indikasi kemiripan citra puzzle digunakan untuk melakukan reposisi puzzle. Berdasarkan hasil pengujian diketahui bahwa akurasi ketepatan hasil reposisi pada sample citra logo, berjumlah 30 citra uji, adalah 100% berhasil memperoleh utuh kembali sesuai citra input logo. Metode ini berpeluang dipergunakan sebagai alternatif pengamanan akses dan juga sebagai model mesin sederhana pada pencarian gambar berbasis potongan gambar.
Innovative digital technologies in the pr-management specialists training for public administration bodies on the blended learning
Authors: Mamatova Tetiana , Chykarenko Iryna , Chykarenko Oleksii , Kravtsova Тetiana , Kravtsov Oleg
Published: September 2022

Objective. The paper examined the information digital technologies effectiveness in the PR-management specialists training for public administration bodies on the blended learning model. The research methodology is based on a mixed-methods approach and a combination of qualitative and quantitative design to fully cover the use of digital technology in the training of professionals under martial law. Results. It has been demonstrated that through a combination of different digital technologies in the higher education institutions of Ukraine, depending on the stage of training and type of lesson, a flexible inclusive approach was used, making provision for the creation of common standards for teaching through digital technology. Innovative digital technologies were used depending on the stage of the educational process (communication and interaction; conducting lectures and seminars; transferring learning materials and exchanging them; digital content development; knowledge evaluation and academic performance rating). As the higher education institutions of Ukraine significantly improved the asynchronous learning models, the preparation level of both educators and students for the complete transition to asynchronous learning given the war was markedly higher. It is deemed that the flexible self-study model during the war ensures the general competencies development, however students have not mastered a sufficient level of professional practical competencies.
Psychological and pedagogical features of training future social service workers
Authors: Zaveryko Nataliia , Matskevich Yuliana , Balukhtina Olena , Sementsova Oksana , Ivanova Larysa
Published: September 2022

The system of training future workers of social services is being transformed in connection with a number of challenges in the social-economic sphere, significantly differentiating within the EU countries. The purpose of the academic paper lies in analysing psychological and pedagogical features in the educational training of social service specialists using the example of EU countries. Methodology. A qualitative design based on a content analysis of the legal framework, statistical data and analytical reports posted on the website of the European Association of Schools of Social Work (2022) have been used in the present research. The results show that social work as an educational training program includes three educational levels: bachelor’s, master’s and doctoral studies. In general, in the EU countries, general requirements regarding the structure and content of educational programs are determined, which are established by legislation. Educational programs are built on a competency-based approach, which involves the formation of professional skills of specialists. Educational institutions specializing in the training of social workers are also experience changes in curricula in accordance with changes in social practice and European education standards, the growing role of practical experience, internships, and research projects. The training programs use the competency-based approach to overcome social problems and changes in social security systems.
Information technologies as a means of overcoming social-cultural barriers in the process of international students training
Authors: Subota Larysa , Kravchuk Oksana , Davydova Zhanna , Tverezovska Nina
Published: September 2022

The intensification of the development of digital technologies and their introduction into educational activities has necessitated the use of digital technologies in the educational process of higher educational institutions in order to overcome language barriers in the provision of educational services to foreign students. The purpose of the research lies in identifying the main problematic aspects and prospects for the application of digitalization as a means of overcoming language barriers in the education of foreign students. The methodological base of the academic paper consists of the following methods of scientific research, namely: the method of theoretical analysis and synthesis, analysis and scientific abstraction, comparison and analogy, grouping and cluster analysis based on the k-means method, generalization and systematization. The results of the conducted research have made it possible to establish that overcoming language barriers in the education of foreign students significantly depends on the level of digitalization of the society and the system of higher education. Intensification of the use of digitalization as a means of overcoming language barriers in teaching foreign students will make it possible to minimize the level of language barriers and ensure the improvement of the quality of the educational process in the online environment through applying digital technologies, as well as create favourable conditions for conducting a simple and understandable language for foreign students.
John Falstaff și dimensiunea carnavalescă a vieții
Authors:   Universitatea de Arte din Târgu Mureș, Conțiu Lia Codrina
Published: September 2022

The struggle between Carnival and Lent, with its symbols – the tavern and the church –, forms the substance of the humor in Shakespeare’s plays written before 1599. This humor is more than a simple comic tool, it is a vision of life, in which the carnivalesque with the vernacular language full of originality, with its laughter devoid of irony and annihilation of the human being, wipes away the veil of delusion and confronts the characters with their own flaws and illusions. In the position of commentator of the deviations of the main characters, we find the fool who mediates between the stage fiction and the audience’s reality, through his semi-detached position, like Sir John Falstaff in “Henry IV“.
Impactos do período seco e geadas no vigor da vegetação: estudo de caso para a bacia hidrográfica do córrego Guariroba, Campo Grande, Mato Grosso do Sul
Authors: Capoane Viviane
Published: September 2022

Períodos de estiagens ocorrem em todas as regiões, mesmo nas de clima úmido, em decorrência da sazonalidade climática e do dinamismo dos processos geradores de pluviosidade. Entretanto, as mudanças climáticas antropogênicas estão impactando os padrões de precipitação e temperatura e, algumas áreas do planeta estão passando por mudanças na frequência e severidade de extremos climáticos, como chuvas fortes, secas, ondas de frio e de calor, incêndios florestais e tempestades de poeira. A bacia hidrográfica do córrego Guariroba é um ambiente naturalmente frágil, altamente suscetível à erosão do solo, no entanto os usos da terra e as práticas de manejo não consideram as restrições e aptidões agrícolas. Diante de um contexto de mudanças climáticas, que constitui um poderoso estressor para os ecossistemas e a biodiversidade, este trabalho analisou a resposta da vegetação aos indicadores climáticos a partir do Índice de Vegetação por Diferença Normalizada. Os índices radiométricos de vegetação foram derivados de imagens Sentinel-2 do ano de 2021 no software SNAP 8.0. Os resultados obtidos mostram que o vigor da vegetação da região centro-oeste reflete o ciclo anual de padrões climáticos e às características de temperatura e precipitação. Contudo, para o ano de 2021, o vigor da vegetação foi severamente impactado em resposta à seca e às geadas. Embora o período de chuvas tenha iniciado na região e a vegetação responde às primeiras chuvas pela rebrota e emergência, o contexto de degradação ambiental na área e das mudanças climáticas antropogênicas, o cenário de 2021 tende a ser repetir e agravar nos próximos anos.
Mapeamento geomorfológico aplicado ao estudo de uso e cobertura da terra no Planalto Central
Authors: Mendes Bruna Cardoso , Martins Éder de Souza , Oliveira Elton Souza
Published: September 2022

O objetivo da pesquisa foi relacionar unidades geomorfológicas ao uso e cobertura da terra em duas bacias hidrográficas no Planalto Central. Com áreas, que somadas, chegam a 34.641,95 km² as bacias do Rio das Almas (GO) e do Rio Maranhão (DF/GO) foram definidas como área de estudo. Para a extração das variáveis morfométricas foram utilizados dados do SRTM e, a partir da composição colorida, com as variáveis de altimetria, declividade e curvatura mínima, respectivamente nos canais RGB, foram mapeadas oito unidades geomorfológicas por meio de vetorização em tela. As unidades definidas foram as seguintes: 1) Chapada e Remanescentes (3,05%); 2) Frentes de Recuo Erosivo (12,51%); 3) Rampas de Colúvio I (4,53%); 4) Planalto Retocado (31,57%); 5) Depressão Interplanáltica (18,69%); 6) Rampas de Colúvio II (11,99%); 7) Serras (14,35%); 8) Depressão Dissecada (3,28%). As unidades obtidas foram integradas aos dados de uso e cobertura da terra em relação às frequências da altimetria e declividade. Essa relação evidenciou que as áreas mais propícias para o desenvolvimento da agricultura ocorrem nas porções mais planas e contínuas, relacionadas com as unidades Chapadas e Remanescentes, Rampas de Colúvio I e II, Planalto Retocado, Depressão Interplanáltica, e a Depressão Dissecada. Já as pastagens, florestas e vegetação nativa ocorrem em todas as unidades geomorfológicas, mas geralmente relacionadas com os relevos mais declivosos e movimentados. Os resultados ainda indicaram que o mapeamento geomorfológico é uma ferramenta importante para compreensão da dinâmica da paisagem uma vez que possibilita identificar os limites naturais da paisagem para o uso e ocupação agrícola e o seu potencial de expansão.
Análise multitemporal da cobertura do solo da Terra Indígena Ituna-Itatá através da classificação supervisionada de imagens de satélites
Authors: Balieiro Bruna Taynara de Souza , Veloso Gabriel Alves
Published: September 2022

Imagens de satélite com diferentes resoluções espaciais podem ser utilizadas para reconhecer a dinâmica do uso e cobertura da superfície terrestre. Este trabalho teve como objetivo analisar a cobertura do solo da Terra Indígena Ituna-Itatá, localizada no norte do Brasil, estado do Pará. Com a avaliação de cinco cenários (2015, 2016, 2017, 2018, 2019 e 2020) o estudo evidenciou as diversas alterações na cobertura da T.I nos últimos anos, considerando se tratar de uma área interditada, com restrição de uso. O trabalho foi elaborado em ambiente SIG, no software QGIS 3.10.9 “A Corunã”, utilizando imagens de satélite Landsat OLI-8 e Sentinel 2-A. Para a classificação das imagens foi adotado o método de classificação supervisionada com coleta e processamento de amostras pelo plugin Dzetsaka. Os resultados permitiram avaliar as alterações da paisagem em um lapso temporal de cinco anos, ratificando a intensificação do desmatamento, abertura ilegal de estradas e inserção significativa de pastagens. Ficou evidenciada a exploração ilegal e desenfreada em uma área protegida destinada aos povos tradicionais.
Contextualist Approach to Teaching Antisemitism in Philosophy Class
Authors: Widmer Elisabeth , Hannula Henriikka
Published: September 2022

This paper argues for a ‘contextualist’ approach to teaching antisemitism in philosophy class. The traditional ‘systematic’ approach emphasizes recognizing and dismantling antisemitic aspects in canonical philosophical texts. The introduced contextualist approach broadens the perspective, treating philosophy as a continuous debate embedded in cultural realities. It focuses on historical controversies rather than isolated arguments, includes the voice and the perspectives of the oppressed, and so has the potential to broaden traditional philosophical canons. In the second half of the paper, we provide a case study of the contextualist approach, applying it to the ‘Berlin antisemitism controversy’ of 1879/80. We argue that the contextualist approach is particularly valuable when dealing with antisemitism as it teaches students to analyze arguments within the socio-political landscape and to identify antisemitic elements. The students thereby acquire the skills to discern antisemitic argumentation in other contexts as well. We suggest that this approach could be used to teach other debates in the history of philosophy, especially those tackling race, sex, and gender issues.
Complexity, Dialogue, and Democracy: The Educational Implications
Authors: Gardner Susan T.
Published: September 2022

There is an unacknowledged disagreement on what kind of dialogue best supports democracy. Many view democracy as analogous to a law court and so view “democratic dialogue” as a contest between competing advocates who have acquired the kind of “steel trap” critical thinking skills that are ideal for winning in the external marketplace of ideas. Others assume that the propensity to seriously reflect on opposing viewpoints within the minds of individuals is ideal for democratic maintenance. It will be argued here that our love affair with “critical thinking” that tends to support an external battle of ideas harms democracy. It will be argued that the complexity of our common humanity, the complexity of our form of governance, the complexity of the approaches needed to face wicked problems, and the complexity of the internal engine of personal development requires that we learn to readily engage in open truth-seeking dialogue with those who hold opposing viewpoints and in so doing, enhance the dimensionality through which we view the world. With regard to the educational implications, this suggests that, since engaging in dialogue across difference is the essence of the pedagogical framework that anchors Philosophy for Children, Philosophy for Children ought to be embraced as an essential component of any educational enterprise that views cultivating democratic citizenship as part of its mandate.
m-MTC for Optimized Communication in 5G
Authors: Dash A. , Pradhan Devasis , Tun Hla Myo , Naing Zaw Min
Published: September 2022

As of late presented 5G New Radio is the primary remote standard intended to help basic and massive machine-type interchanges (m-MTC). Notwithstanding, it is previously becoming apparent that a portion of the additional requesting prerequisites for MTC cannot be completely upheld by 5G organizations. Close by, arising use cases and applications towards 2030 will lead to new and more rigid necessities on remote network and MTC specifically. This new age of portable correspondence frameworks will in general turn into an innovation stage that will empower the improvement of new applications, plans of action, and ventures, for example, huge machine-type correspondences. This will be conceivable through making a satisfactory environment that could give monstrous machine-type correspondence utilizing a solitary stage in light of the Internet of Things (IoT) idea. This paper reflects the brief importance of massiveness of machine type communication in 5G eras with challenges and other important issues.
Una herramienta práctica para el profesorado sobre prácticas inspiradoras para la prevención del abandono escolar temprano en escenarios educativos multiculturales en Europa
Authors: Rodríguez Izquierdo Rosa María
Published: September 2022

El objetivo de esta herramienta es ofrecer al profesorado en formación y en servicio una serie de prácticas fundamentadas en la investigación, así como en prácticas generadas por las escuelas y el profesorado, que pueden ayudar a prevenir la desvinculación escolar y el abandono escolar temprano (AET) del estudiantado de las escuelas de toda Europa. Las prácticas en la herramienta incluyen actividades, proyectos y programas que están destinados a involucrar activamente al estudiantado y contrarrestar el AET. Esta selección de prácticas ayudará a los/as maestros/as a convertirse en agentes de cambio más eficaces en la prevención de la desvinculación escolar y el abandono escolar temprano.