bluuebunny/crossref_metadata_2025 huggingface dataset:
Abstract 46: Clinical Outcomes and Quality Metrics of Cervical Cancer Treatment in Rwanda
Authors: Umutoni Victoria , Shyirambere Cyprien , Katznelson Ethan , Nguyen Cam , Bigirimana Jean Bosco , Umwizerwa Aline , Paciorek Alan , Bazzett-Matabele Lisa , Ntasumbumuyange Diomede , Triedman Scott , Shulman Lawrence , Mpunga Tharcisse , DeBoer Rebecca
Published: July 2021

Purpose: Cervical cancer is a leading cause of cancer-related mortality in Africa. As treatment capacity expands, it is critical to evaluate outcomes and identify targets for quality improvement. We describe a cohort of cervical cancer patients at Butaro Cancer Center (BCCOE) in rural Rwanda, many co-managed by gynecologic specialists at the national referral hospital and a subset referred for definitive chemoradiotherapy plus brachytherapy (CRT) in Nairobi based on available funds and estimated curability.

Methosd: We conducted a retrospective cohort study of all patients with cervical cancer seen at BCCOE between 6/2016 and 6/2018. Data were extracted from clinical charts and analyzed using descriptive statistics and Kaplan Meier method.

Results: 377 patients were included; median age 54 years, 21% HIV positive. Most patients (85%) had squamous cell carcinoma. A majority (67%) had stage III or IV disease at presentation. Several early stage patients underwent radical hysterectomy (n=34). 114 (30%) received CRT, representing 45% of eligible candidates. Of these, 30 (26%) received upfront CRT after a median 126 days from diagnosis, and 83 (73%) received “temporizing” carboplatin/paclitaxel while awaiting CRT, with a median 56 days from diagnosis to chemotherapy. Patients sent for upfront CRT were younger (p <0.001) and more likely stage II (p <0.001). Nevertheless, there was no survival difference between upfront CRT versus temporizing chemotherapy before CRT. Most chemotherapy recipients (77%) reported improvement in symptoms. Estimated 3-year overall survival was 94% with radical hysterectomy (95% CI 63-99%), 66% with CRT (95% CI 54-75%), 11% with chemotherapy only (95% CI 5-19%), and 7% with no treatment (95% CI 2-17%) (p<0.001).

Conclusion: Multi-modality treatment of cervical cancer is effective in low resource settings through coordinated care and pragmatic approaches. Our data support a role for temporizing chemotherapy if delays to CRT are anticipated. Expanded and timely access to radiation is urgently needed.

Citation Format: Victoria Umutoni, Cyprien Shyirambere, Ethan Katznelson, Cam Nguyen, Jean Bosco Bigirimana, Aline Umwizerwa, Alan Paciorek, Lisa Bazzett-Matabele, Diomede Ntasumbumuyange, Scott Triedman, Lawrence Shulman, Tharcisse Mpunga, Rebecca DeBoer. Clinical Outcomes and Quality Metrics of Cervical Cancer Treatment in Rwanda [abstract]. In: Proceedings of the 9th Annual Symposium on Global Cancer Research; Global Cancer Research and Control: Looking Back and Charting a Path Forward; 2021 Mar 10-11. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2021;30(7 Suppl):Abstract nr 46.
A Phase 2 Study of Camrelizumab for Advanced Hepatocellular Carcinoma: Two-Year Outcomes and Continued Treatment beyond First RECIST-Defined Progression
Authors: Ren Zhenggang , Qin Shukui , Meng Zhiqiang , Chen Zhendong , Chai Xiaoli , Xiong Jianping , Bai Yuxian , Yang Lin , Zhu Hong , Fang Weijia , Lin Xiaoyan , Chen Xiaoming , Li Enxiao , Wang Linna , Yan Ping , Zou Jianjun
Published: June 2021

Introduction: In a multicenter, open-label, parallel-group, randomized, phase 2 study for pretreated advanced hepatocellular carcinoma (HCC), camrelizumab showed potent antitumor activity and acceptable safety profile. The aim of this report was to provide long-term data and evaluate potential benefit of treatment with camrelizumab beyond progression. Methods: From November 15, 2016, to November 16, 2017, 217 patients received camrelizumab 3 mg/kg intravenously every 2 or 3 weeks. Treatment beyond first Response Evaluation Criteria in Solid Tumors (RECIST)-defined progression (TBP) with camrelizumab was allowed. Results: At data cutoff of December 16, 2019 (>2 years after the last patient enrollment; median duration of follow-up, 13.2 months [IQR 5.7–25.8]), 14 (43.8%) of the 32 responses per blinded independent central review were ongoing. The median duration of response was not reached (range 2.5–30.5 + months). The ongoing response rates at 12, 18, and 24 months were 68.3% (95% confidence interval [CI] 47.7–82.2), 59.8% (95% CI 38.8–75.6), and 53.1% (95% CI 31.0–71.0), respectively. The median overall survival (OS) was 14.2 months (95% CI 11.5–16.3). The 18- and 24-month OS rates were 41.3% (95% CI 34.6–47.9) and 33.7% (95% CI 27.3–40.2), respectively. Of the 172 patients who experienced RECIST-defined progression per investigator, 102 received TBP, while 70 did not (non-TBP). The median OS was 16.9 months (95% CI 13.3–22.6) in the TBP group versus 9.4 months (95% CI 5.8–14.8) in the non-TBP group, and the 18- and 24-month OS rates were 47.5% (95% CI 37.3–56.9) versus 33.1% (95% CI 22.3–44.3) and 38.8% (95% CI 29.2–48.4) versus 23.2% (95% CI 13.8–34.1), respectively. No new safety signals of camrelizumab were observed. Conclusions: With prolonged follow-up, camrelizumab continues to demonstrate the durable response and long survival in pretreated advanced HCC patients with manageable toxicities, especially in those who continued the treatment beyond first RECIST-defined progression.
Ansa Pancreatica, an Uncommon Cause of Acute, Recurrent Pancreatitis
Authors: Shaikh Danial H. , Alemam Ahmed , von Ende Jennifer , Ghazanfar Haider , Dev Anil , Balar Bhavna
Published: July 2021

The pancreatic duct is vulnerable to developmental anomalies which may produce variations in its course and/or its configuration. Ansa pancreatica is the least common anatomic variant. It is characterized by the formation of an “S-shaped loop” from the main pancreatic duct to the minor papilla. Ansa pancreatica has been implicated as a cause of recurrent acute pancreatitis. We review existing literature on pancreatitis secondary to the ansa deformity and present a case of recurrent acute pancreatitis in a patient who was ultimately found to have the ansa deformity on endoscopic ultrasound.
Putative Digenic GJB2/MYO7A Inheritance of Hearing Loss Detected in a Patient with 48,XXYY Klinefelter Syndrome
Authors: Zhang Qin , Qin Tiantian , Hu Wenmu , Janjua Muhammad Usman , Jin Ping
Published: June 2021

Objectives: Nonsyndromic hearing loss (NSHL) is the most frequent type of hereditary hearing impairment. Here, we explored the underlying genetic cause of NSHL in a three-generation family using whole-exome sequencing. The proband had concomitant NSHL and rare 48,XXYY Klinefelter syndrome. Material and Methods: Genomic DNA was extracted from the peripheral blood of the proband and their family members. Sanger sequencing and pedigree verification were performed on the pathogenic variants filtered by whole-exome sequencing. The function of the variants was analyzed using bioinformatics software. Results: The proband was digenic heterozygous for p.V37I in the GJB2 gene and p.L347I in the MYO7A gene. The proband’s mother had normal hearing and did not have any variant. The proband’s father and uncle both had NSHL and were compound for the GJB2 p.V37I and MYO7A p.L347I variants, thus indicating a possible GJB2/MYO7A digenic inheritance of NSHL. 48,XXYY Klinefelter syndrome was discovered in the proband after the karyotype analysis, while his parents both had normal karyotypes. Conclusions: Our findings reported a putative GJB2/MYO7A digenic inheritance form of hearing loss, expanding the genotype and phenotype spectrum of NSHL. In addition, this is the first report of concomitant NSHL and 48,XXYY syndrome.
Unraveling the Mystery of Polyvalent Immunoglobulins in Belgium: Do We Have an Indication?
Authors: de Meester Christophe , Bourgeois Jolyce , Devriese Stephan , San Miguel Lorena
Published: June 2021

Introduction: Worldwide, polyvalent immunoglobulin (Ig) use is rising. Together with the limited supply, this puts pressure on Ig availability. A clear overview on a country’s usage pattern helps in forecasting future needs. This research aims to provide an overview of Ig use in Belgium on the different indications, including an estimation of off-label use. Methods: Multiple data sources were used. Existing claims data were explored for reimbursed Ig use between 2010 and 2018. General 2018 sales data from the firms were compared to the reimbursed use to serve as a proxy for off-label use. Indication-specific information was retrieved via a proxy: diagnostic codes available during day-care and inpatient hospitalization. Results: In 2018, 7,556 patients had reimbursed Ig. The most prevalent indication, both in terms of patient numbers and volume, was primary immunodeficiency (PID). In Belgian hospitals, the currently reimbursed indications represented 84.4% of patients (PID [≈35%], secondary immunodeficiency [SID] [≈21%], primary immune thrombocytopenia [≈10%], chronic inflammatory demyelinating neuropathy [CIDP] [≈8%], Guillain-Barre syndrome [≈6%], Kawasaki [≈2%], streptococcal toxic shock [≈2%] and multiple motor neuropathy [≈1%]), and 82.4% of Ig use (predominantly PID [≈33%] and CIDP [≈21%]). Although no direct data on off-label use were available, crude estimates derived from indirect sources showed a proportion of around 15.4%. Conclusion: Our research offers the first comprehensive overview on Ig use in Belgium, including a detailed description of reimbursed use, as well as approximations to off-label use. In view of increasing pressure on Ig availability, better understanding Ig needs and trends, would benefit from an effective indication-specific national registry system (ideally covering both reimbursed and nonreimbursed use).
Підготовка щелепно-лицевих хірургів в Україні: проект моделі
Authors: Маланчук В. О. , Кульбашна Я. А. , Нагірний Я. П. , Шувалов С. М.
Published: June 2021

Резюме. У статті розкрито актуальність підготовки фахівців із щелепно-лицевої хірургії в Україні та упровадження фаху «Щелепно-лицева хірургія». Обговорюються існуючі у світі моделі підготовки на базі як загальномедичної, так і стоматологічної освіти, яка в Україні забезпечує високий рівень компетентності з базових і загальномедичних дисциплін.

Мета дослідження –  розробити проект моделі підготовки фахівців із фаху «Щелепно-лицева хірургія».

Результати досліджень та їх обговорення. Підготовка щелепно-лицевих хірургів – це тривалий і відповідальний процес, який залежить як від особистісних якостей і компетентності лікаря, так і умов та спроможностей держави. На основі аналізу нормативних документів визначено спеціальності, поглиблені знання з яких необхідні для підготовки щелепно-лицевих хірургів, а також терміни  з їх вивчення у рамках спеціалізації. Представлено проект моделі підготовки щелепно-лицевого хірурга на базі вищої медичної стоматологічної освіти кваліфікаційного рівня «лікар-стоматолог» і освітнього рівня «магістр стоматології» (термін навчання 6 років і захист науково-дослідницької роботи), один рік інтернатури і двох років резидентури.
АСПЕКТИ КОРПОРАТИВНОЇ КУЛЬТУРИ ЗАКЛАДІВ ОХОРОНИ ЗДОРОВʼЯ ЗА УМОВ РЕФОРМУВАННЯ ГАЛУЗІ
Authors: Литвинова О. Н. , Абашник Н. М.
Published: June 2021

У статті розглянуто питання корпоративної культури та її особливостей в закладах охорони здоров’я в період реформування системи охорони здоров’я. Акцентовано на проблемах корпоративної культури в сучасних умовах інформаційного суспільства в закладах охорони здоров’я, порушених різними авторами.
ОПТИМІЗАЦІЯ ПІСЛЯДИПЛОМНОЇ ПІДГОТОВКИ МЕДИЧНИХ СЕСТЕР З ПИТАНЬ ПАЛІАТИВНОЇ ТА ХОСПІСНОЇ ДОПОМОГИ НАСЕЛЕННЮ В УКРАЇНІ
Authors: Боб А. О. , Чукур О. О. , Воронюк І. О. , Ференц Л. З.
Published: June 2021

У статті представлено сучасні підходи і методи безперервної професійної підготовки медичних сестер з питань надання паліативної та хоспісної допомоги населенню, що набуває особливого значення за умов реформування системи охорони здоровʼя в Україні. Показано, що оптимізація додипломної і післядипломної професійної підготовки медичних працівників з питань паліативної та хоспісної допомоги має велике значення для забезпечення високої якості надання медичної допомоги населенню і вимагає в процесі безперервної післядипломної освіти проведення циклів тематичного удосконалення, семінарів, тренінгів, стажувань, навчальних поїздок та роботи в тренінгових центрах.
ДОСЛІДЖЕННЯ ДИНАМІКИ ФОРМУВАННЯ ОСОБИСТІСНИХ ЯКОСТЕЙ МАЙБУТНІХ ТА ПРАКТИКУЮЧИХ МЕДИЧНИХ СЕСТЕР ТА ЇХ МОТИВАЦІЙНИЙ ВПЛИВ У ПРОЦЕСІ ПРОФЕСІЙНОЇ ДІЯЛЬНОСТІ
Authors: Радецька Л. В. , Лаба І. О. , Смачило А. І. , Лопатенко К. О. , Баумер М. М. , Нечаєва О. О.
Published: June 2021

Дослідження ґрунтувалося на результатах клініко-психологічного, психодіагностичного, соціально-демографічного обстеження студентів медичного коледжу та практикуючих медичних сестер. Виходячи з результатів дослідження, вважаємо, що впровадження структурно-діяльнісної моделі розвитку професійних особистісних якостей медичних сестер на першому етапі формування професійної копінг-поведінки може використовуватися в незначній модифікації при підготовці не лише медичних сестер, а й інших фахівців, професійна діяльність яких пов’язана з системою відносин «людина – людина».
БЕЗПЕЧНІ ПІДХОДИ ДО ЛІКУВАННЯ ПАЦІЄНТІВ З ОЖИРІННЯМ У ПОЄДНАННІ З КОГНІТИВНИМИ РОЗЛАДАМИ
Authors: Наумова Л. В. , Груба С. О. , Наумова У. О.
Published: June 2021

Частими супутніми захворюваннями ожиріння є такі метаболічні порушення, як цукровий діабет і дислі­підемія, які виконують роль провідних чинників ризику серцево-судинних захворювань. При ожирінні зростає вірогідність розвитку інших захворювань і метаболічних порушень. Проведено обстеження та лікування 20 хворих з ожирінням II ступеня з супутніми когнітивними розладами. Для лікування призначено модифікацію способу життя, корекцію харчування та метформін у початковій дозі 500 мг 3 рази на добу з поступовим збільшенням до оптимальної. Відзначено поступове зниження маси тіла на 2,5–3,5 кг на місяць, середнє зменшення маси тіла становило 25–30 кг на рік.
ROBUSTNESS EVALUATION OF HPLC DETERMINATION OF ATORVASTATIN AND LISINOPRIL ON COLUMN PUROSPHER C8 STAR IN PHARMACEUTICALS
Authors: Shulyak N. S. , Abbeyquaye A. D. , Koval D. B.
Published: June 2021

Introduction. Innovative pharmaceutical development of various antihypertensive drugs with statins and the creation of domestic fixed-dose combinations of drugs with different effects is an urgent task of modern pharmacy, which will help attract more patients to the treatment and prevention of cardiovascular disease. Pharmaceutical development of atorvastatin and lisinopril by our scientific group proposes for using the ratio of (1/1) for lisinopril (10 mg) and atorvastatin (10 mg). HPLC (High-Performance Liquid Chromatography) technique is adopted as it is considered as the most common technique in realm of quality control analysis.

The aim of the study – to evaluate the robustness of HPLC (High-Performance Liquid Chromatography) method for the quantitation of lisinopril and atorvastatin and determine the analytical parameters that present greater influence in the final results of the analysis.

Research Methods. An efficient method to assess the robustness of analytical methods is by Youden’s test, by means of an experiment design which involves seven analytical parameters combined in eight tests. In the recent studies, we assessed the robustness of a chromatographic method to quantify lisinopril and atorvastatin in tablets using Youden’s test.

Results and Discussion. By using the criteria of Youden’s test, HPLC method proved to be greatly robust regarding content of lisinopril and atorvastatin, when variations in seven analytical parameters were introduced. The most variation in effects of the analytical parameters in retention time (Rt) for lisinopril and atorvastatin HPLC quantitation was when used column supplier. Purospher C8 STAR (55 mm x 4mm, 5 μm) is based on high purity silica and an almost complete surface coverage. Purospher C8 STAR provides excellent peak symmetry for acidic, basic and even chelating compounds, highest column efficiency in terms of the number of theoretical plates, and exceptional stability from pH 1.5 to 10.5.

Conclusion. Youden’s test can be applied successfully for the ro­bustness evaluation in validation process of analytical methods and results ontained in our work should be interest to the scientific population dealing with pharmaceutical analytical chemistry.
ВПЛИВ НОВОГО ПОХІДНОГО 4-АМІНОБУТАНОВОЇ КИСЛОТИ НА СТАН СЕНСОМОТОРНОЇ КОРИ ВЕЛИКИХ ПІВКУЛЬ ГОЛОВНОГО МОЗКУ ЩУРІВ ЗА УМОВ ЕКСПЕРИМЕНТАЛЬНОЇ ІШЕМІЇ
Authors: Міщенко О. Я. , Палагіна Н. Ю. , Лар’яновська Ю. Б.
Published: June 2021

Вступ. Пошук нових ноотропних препаратів, здатних поліпшувати когнітивні порушення, що виникають у результаті порушення мозкового кровообігу, є актуальним науковим завданням. Перспективними в цьому відношенні вважають нові похідні 4-амінобутанової кислоти, синтезовані в Національному фармацевтичному університеті, серед 11 з яких було обрано субстанцію-лідер за антиамнестичною активністю під шифром КГМ-5, що проявляє і антигіпоксичну активність.

Мета дослідження – вивчити вплив сполуки КГМ-5 на стан сенсомоторної кори великих півкуль головного мозку щурів на моделі гострого порушення мозкового кровообігу.

Методи дослідження. Проводили гістологічні дослідження стану сенсомоторної кори великих півкуль головного мозку щурів з моделлю гострого порушення мозкового кровообігу (на 6-ту добу), яке викликали шляхом оклюзії лівої загальної сонної артерії. Головний мозок після вилучення з черепа фіксували в 96° етанолі, потім робили фронтальний розріз на рівні передніх країв скроневих часток. Зразки заливали у парафін, одну частину фарбували гематоксилін-еозином, іншу – тіоніном за методом Ніссля. Перегляд мікропрепаратів здійснювали під світловим мікроскопом Granum, мікрофотографування мікроскопічних зображень – цифровою відеокамерою Granum ДСМ 310. Фотознімки обробляли на комп’ютері Pentium 2,4GHz за допомогою програми Toup View.

 Результати й обговорення. У щурів із гострим порушенням мозкового кровообігу в ділянці сенсомоторної кори великих півкуль головного мозку виявлено ознаки порушення кровообігу: спазм артеріол, венозну гіперемію, перикапілярний набряк; пірамідні нейрони з морфологічними змінами незворотного характеру. Відзначено підвищення кількості гіпер- та гіпохромних нейронів, гліо- і перинейронального індексів та індексу альтерації. Сполука КГМ-5 поліпшувала мозковий кровообіг у щурів із гострим його порушенням, про що свідчило зменшення вираження спазму капілярів та перикапілярного набряку, збільшувала виживання пірамідних нейронів сенсомоторної кори великих півкуль головного мозку, зменшувала відносну частку незворотно змінених клітин, що підтверджено зниженням індексу альтерації нейронів, гліо- та перинейронального сателітного індексів.

Висновки. Встановлено здатність нового похідного 4-амінобутанової кислоти – сполуки КГМ-5 поліпшувати мозковий кровообіг, збільшувати виживання пірамідних нейронів, зменшувати кількість незворотно змінених клітин. Це доводить наявність у сполуки КГМ-5 церебропротективних властивостей, за виразністю яких вона не поступається препарату порівняння “Пікамілон”.
ТЕХНОЛОГІЧНІ АСПЕКТИ ОТРИМАННЯ ЕКСТРАКТУ З КВІТОК ХРИЗАНТЕМИ САДОВОЇ СОРТУ ПЕКТОРАЛЬ
Authors: Козир Г. Р. , Каріна Ю. В.
Published: June 2021

Вступ. Хронічний стрес, роздратованість та порушення сну знижують якість життя людини, послаблюють імунітет, підвищують ризик розвитку різних запальних захворювань. Тому зростає попит на лікарські засоби рослинного походження і виникає необхідність розширити їх асортимент. Іноземні джерела свідчать про перспективність використання квіток хризантеми як седативного та протисудомного засобу. Через це перспективною була розробка технології отримання екстракту з квіток хризантеми садової.

Мета дослідження – вивчити вплив деяких фармацевтичних факторів на ступінь вилучення діючих речовин із квіток хризантеми садової сорту Пектораль для розробки технології отримання сухого екстракту на основі цієї рослини, який у подальшому використовуватимуть як напівпродукт у виробництві нових лікарських форм.

Методи дослідження. Вивчено вплив на ступінь вилучення біологічно активних речовин таких фармацевтичних факторів, як природа екстрагенту, співвідношення вихідна сировина/екстрагент і метод екстрагування. Критеріями оцінки отриманих сухих субстанцій слугували кількісний вміст суми фенольних сполук (перерахунок на галову кислоту), кількісний вміст суми флавоноїдів (перерахунок на рутин) та кількісний вміст суми гідроксикоричних кислот (перерахунок на хлорогенову кислоту), які визначали спект­рофотометричним методом на спектрофотометрі Lambda 25 Perkin Elmer.

Результати й обговорення. На основі математичного планування експерименту вивчено закономірності вилучення фенольних сполук, флавоноїдів та гідроксикоричних сполук із квіток хризантеми садової сорту Пектораль залежно від концентрації використаного екстрагенту етанолу, співвідношення сировина/екстрагент і методу екстрагування.

Висновок. Встановлено, що оптимальним способом отримання екстракту з квіток хризантеми садової сорту Пектораль є метод дробної мацерації 70 % етанолом при співвідношенні лікарська рослинна сировина/екстрагент 1:8.
Meios de comunicação na territorialização do capital
Authors: Barros Janaina Visibeli
Published: June 2021

O texto problematiza o papel fundamental dos meios de comunicação na territorialização do capital. Para tanto faz uma reflexão teórica na qual discute o conceito de território e territorialização do capital, a partir do entendimento de que os meios de comunicação são meios de produção. Busca-se demonstrar que as dinâmicas econômicas e políticas que orientam a territorialização das organizações midiáticas, formatam os produtos discursivos que são por elas produzidos. Mesmo em tempos de popularização da internet e aparente democratização da comunicação, deter o acesso aos meios de produção da informação ainda é uma forma de isolamento territorial e manutenção de poder de líderes locais.
Comunicando o conhecimento acadêmico além do texto acadêmico escrito: uma análise autoetnográfica do experimento da instalação Mirror Palace of Democracy
Authors: Carpentier Nico
Published: June 2021

O artigo discute inicialmente cinco abordagens que visam transcender, complementar ou desestabilizar a hegemonia do texto acadêmico escrito. Na segunda parte, o experimento da instalação Mirror Palace of Democracy, que tinha o objetivo explícito de ir além do texto acadêmico escrito, permanecendo no domínio da comunicação do conhecimento acadêmico, é analisada autoetnograficamente. A experiência permitiu refletir sobre o caráter integrado e iterativo da comunicação acadêmica, sobre a identidade híbrida acadêmico-artística e sobre a diversificação de públicos. Tanto a discussão teórica como a instalação Mirror Palace of Democracy fazem parte de um apelo a mais experimentação e teorização da comunicação acadêmica multimodal e/ou baseada nas artes.
Capitalismo de vigilância: a vertente Mattelart e a crítica aos processos midiáticos
Authors: Kalikoske Andres
Published: June 2021

O artigo analisa o trinômio comunicação, capitalismo e vigilância, recuperando as convergências estabelecidas entre esses elementos à luz das contribuições teóricometodológicas de Mattelart. Considera que o modelo de negócio das indústrias culturais já não explora somente o diagrama que envolve a produção, a circulação e o consumo midiáticos, somando-se a esses processos programações algorítmicas capazes de extrair dados em escala de seus usuários em prol da geração de novos produtos e serviços. Avalia o cruzamento entre os campos cultural, político, econômico e tecnológico nos processos midiáticos para criticar o contrato social imposto pelas empresas de tecnologia inseridas no contexto do capitalismo de vigilância.
Uma economia política da comunicação internacional: a contribuição de Armand Mattelart para a análise do sistema-mundo das mídias
Authors: Aguiar Pedro
Published: June 2021

Este ensaio parte da obra de Armand Mattelart para vislumbrar um programa de pesquisa orientado para a abordagem crítica e estrutural da comunicação internacional nas suas desigualdades, assimetrias e relações de dependência. Com uma revisão das reflexões do pensador belga nos seus pontos de contato com a proposição teórico-metodológica da análise dos sistemas-mundo, de Immanuel Wallerstein, e buscando articular as duas perspectivas, especialmente na concepção de comunicação-mundo como sistema-mundo da comunicação, o trabalho delineia uma área de interseção entre três vertentes teóricas: a comunicação internacional, a economia política da comunicação e a economia política internacional.
Musicalidades dialéticas: transmetodologia para uma ciência sonora
Authors: Martini Felipe Gue
Published: June 2021

O artigo propõe um diálogo sobre a concepção epistemológica do método chamado musicalidades dialéticas, que tem como princípios norteadores teorias da vertente Mattelart, lidas e ampliadas por Alberto Efendy Maldonado, através do conceito de transmetodologia. O autor apresenta quatro princípios norteadores e como se realizam em práticas investigativas através de desenho metodológico singular e aplicado.
Para ler Mattelart/Dorfman, 50 anos depois: mas... e os quadrinhos?
Authors: Lucas Ricardo Jorge de Lucena
Published: June 2021

O presente texto revisita o livro Para Ler o Pato Donald, publicado em 1971, e um dos títulos fundamentais para iniciar a consolidação do nome de Armand Mattelart (junto com Ariel Dorfman, coautor) no Brasil como teórico da Comunicação, bem como seus comentários e entrevistas posteriores à obra. Num momento posterior, indagamos sobre essa (falta de) percepção dos quadrinhos como uma espécie de “não objeto” de pesquisa, obscurecidos que ficaram sob a ótica do “imperialismo cultural”, sob três aspectos: a descentralização da produção Disney; o problema da tradução; e a ausência de informações sobre a produção de quadrinhos no Chile.
Os Mattelart hoje: entre a continuidade e a ruptura: uma visão desmistificadora dos “novos paradigmas”
Authors: Kaplún Mario
Published: June 2021

Entrevista histórica de Mario Kaplún (1923-1998), publicada originalmente em Dia-Logos de la Comunicación, nº 21 (julho de 1988), com Armand e Michèle Mattelart, inédita em português e inglês.
Leer la biblioteca mattelartiana
Authors: Fuentes Navarro Raúl
Published: June 2021

El propósito de este artículo es aportar un ángulo de análisis poco desarrollado y aprovechado en los estudios de comunicación en América Latina, a propósito de la reconstrucción de la influencia de la obra de Armand Mattelart en este campo, extendida durante más de cincuenta años. Los recuentos de citas, facilitados por los recursos digitales disponibles en la actualidad, se han desarrollado desde hace décadas en diversos ámbitos científicos como indicadores de influencia y reconocimiento, que no obstante, es necesario contextualizar con cautela.
Silvio Waisbord: diversidade e fragmentação – o campo da comunicação como uma pós-disciplina e seus desdobramentos na contemporaneidade
Authors: Saad Elizabeth , Ramos Daniela Osvald
Published: June 2021

Entrevista com o pesquisador Silvio Waisbord, abordando principalmente seu livro Communication: A Post-Discipline (2019).
Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit
Authors: Logantha Sunil Jit R.J. , Cai Xue J. , Yanni Joseph , Jones Caroline B. , Stephenson Robert S. , Stuart Luke , Quigley Gillian , Monfredi Oliver , Nakao Shu , Oh Il-Young , Starborg Tobias , Kitmitto Ashraf , Vohra Akbar , Hutcheon Robert C. , Corno Antonio F. , Jarvis Jonathan C. , Dobrzynski Halina , Boyett Mark R. , Hart George
Published: June 2021

Background:

Purkinje fibers (PFs) control timing of ventricular conduction and play a key role in arrhythmogenesis in heart failure (HF) patients. We investigated the effects of HF on PFs.

Methods:

Echocardiography, electrocardiography, micro-computed tomography, quantitative polymerase chain reaction, immunohistochemistry, volume electron microscopy, and sharp microelectrode electrophysiology were used.

Results:

Congestive HF was induced in rabbits by left ventricular volume- and pressure-overload producing left ventricular hypertrophy, diminished fractional shortening and ejection fraction, and increased left ventricular dimensions. HF baseline QRS and corrected QT interval were prolonged by 17% and 21% (mean±SEMs: 303±6 ms HF, 249±11 ms control; n=8/7;
P
=0.0002), suggesting PF dysfunction and impaired ventricular repolarization. Micro-computed tomography imaging showed increased free-running left PF network volume and length in HF. mRNA levels for 40 ion channels, Ca
2+
-handling proteins, connexins, and proinflammatory and fibrosis markers were assessed: 50% and 35% were dysregulated in left and right PFs respectively, whereas only 12.5% and 7.5% changed in left and right ventricular muscle. Funny channels, Ca
2+
-channels, and K
+
-channels were significantly reduced in left PFs. Microelectrode recordings from left PFs revealed more negative resting membrane potential, reduced action potential upstroke velocity, prolonged duration (action potential duration at 90% repolarization: 378±24 ms HF, 249±5 ms control; n=23/38;
P
<0.0001), and arrhythmic events in HF. Similar electrical remodeling was seen at the left PF-ventricular junction. In the failing left ventricle, upstroke velocity and amplitude were increased, but action potential duration at 90% repolarization was unaffected.

Conclusions:

Severe volume- followed by pressure-overload causes rapidly progressing HF with extensive remodeling of PFs. The PF network is central to both arrhythmogenesis and contractile dysfunction and the pathological remodeling may increase the risk of fatal arrhythmias in HF patients.
Phonetic Skills and Verbal Memory Capacity Predict Phonetic-based Word Learning: An Event-related Potential Study
Authors: Elmer Stefan , Dittinger Eva , Brocchetto Julia , François Clément , Besson Mireille , Jäncke Lutz , Rodríguez-Fornells Antoni
Published: June 2021

The learning of new words is a challenge that accompanies human beings throughout the entire life span. Although the main electrophysiological markers of word learning have already been described, little is known about the performance-dependent neural machinery underlying this exceptional human faculty. Furthermore, it is currently unknown how word learning abilities are related to verbal memory capacity, auditory attention functions, phonetic discrimination skills, and musicality. Accordingly, we used EEG and examined 40 individuals, who were assigned to two groups (low [LPs] and high performers [HPs]) based on a median split of word learning performance, while they completed a phonetic-based word learning task. Furthermore, we collected behavioral data during an attentive listening and a phonetic discrimination task with the same stimuli to address relationships between auditory attention and phonetic discrimination skills, word learning performance, and musicality. The phonetic-based word learning task, which also included a nonlearning control condition, was sensitive enough to segregate learning-specific and unspecific N200/N400 manifestations along the anterior–posterior topographical axis. Notably, HPs exhibited enhanced verbal memory capacity and we also revealed a performance-dependent spatial N400 pattern, with maximal amplitudes at posterior electrodes in HPs and central maxima in LPs. Furthermore, phonetic-based word learning performance correlated with verbal memory capacity and phonetic discrimination skills, whereas the latter was related to musicality. This experimental approach clearly highlights the multifaceted dimensions of phonetic-based word learning and is helpful to disentangle learning-specific and unspecific ERPs.
Emotion Regulation Failures Are Preceded by Local Increases in Sleep-like Activity
Authors: Avvenuti Giulia , Bertelloni Davide , Lettieri Giada , Ricciardi Emiliano , Cecchetti Luca , Pietrini Pietro , Bernardi Giulio
Published: June 2021

Emotion self-regulation relies both on cognitive and behavioral strategies implemented to modulate the subjective experience and/or the behavioral expression of a given emotion. Although it is known that a network encompassing fronto-cingulate and parietal brain areas is engaged during successful emotion regulation, the functional mechanisms underlying failures in emotion suppression (ES) are still unclear. In order to investigate this issue, we analyzed video and high-density EEG recordings of 20 healthy adult participants during an ES and a free expression task performed on two consecutive days. Changes in facial expression during ES, but not free expression, were preceded by local increases in sleep-like activity (1–4 Hz) in brain areas responsible for emotional suppression, including bilateral anterior insula and anterior cingulate cortex, and in right middle/inferior frontal gyrus (p < .05, corrected). Moreover, shorter sleep duration the night before the ES experiment correlated with the number of behavioral errors (p = .03) and tended to be associated with higher frontal sleep-like activity during ES failures (p = .09). These results indicate that local sleep-like activity may represent the cause of ES failures in humans and may offer a functional explanation for previous observations linking lack of sleep, changes in frontal activity, and emotional dysregulation.
The Precentral Gyrus Contributions to the Early Time-Course of Grapheme-to-Phoneme Conversion
Authors: Kaestner Erik , Wu Xiaojing , Friedman Daniel , Dugan Patricia , Devinsky Orrin , Carlson Chad , Doyle Werner , Thesen Thomas , Halgren Eric
Published: June 2021

As part of silent reading models, visual orthographic information is transduced into an auditory phonological code in a process of grapheme-to-phoneme conversion (GPC). This process is often identified with lateral temporal-parietal regions associated with auditory phoneme encoding. However, the role of articulatory phonemic representations and the precentral gyrus in GPC is ambiguous. Though the precentral gyrus is implicated in many functional MRI studies of reading, it is not clear if the time course of activity in this region is consistent with the precentral gyrus being involved in GPC. We recorded cortical electrophysiology during a bimodal match/mismatch task from eight patients with perisylvian subdural electrodes to examine the time course of neural activity during a task that necessitated GPC. Patients made a match/mismatch decision between a 3-letter string and the following auditory bi-phoneme. We characterized the distribution and timing of evoked broadband high gamma (70–170 Hz) as well as phase-locking between electrodes. The precentral gyrus emerged with a high concentration of broadband high gamma responses to visual and auditory language as well as mismatch effects. The pars opercularis, supramarginal gyrus, and superior temporal gyrus were also involved. The precentral gyrus showed strong phase-locking with the caudal fusiform gyrus during letter-string presentation and with surrounding perisylvian cortex during the bimodal visual-auditory comparison period. These findings hint at a role for precentral cortex in transducing visual into auditory codes during silent reading.
Which types of online evidence show the nonacademic benefits of research? Websites cited in UK impact case studies
Authors: Kousha Kayvan , Thelwall Mike , Abdoli Mahshid
Published: June 2021

While funders increasingly request evidence of the societal benefits of research, all academics in the UK must periodically provide this information to gain part of their block funding within the Research Excellence Framework (REF). The impact case studies produced in the UK are public and can therefore be used to gain insights into the types of sources used to justify societal impact claims. This study focuses on the URLs cited as evidence in the last public REF to help researchers and resource providers to understand what types can be used and the disciplinary differences in their uptake. Based on a new semiautomatic method to classify the URLs cited in impact case studies, the results show that there are a few key online types of source for most broad fields, but these sources differ substantially between subject areas. For example, news websites are more important in some fields than others, and YouTube is sometimes used for multimedia evidence in the arts and humanities. Knowledge of the common sources selected independently by thousands of researchers may help others to identify suitable sources for the complex task of evidencing societal impacts.
Energetika: Gleb Krzhizhanovskii’s Conception of the Nature–Society Metabolism
Authors: Russ Daniela
Published: June 2021

In recent years, there has been a growing interest in the relation between Marxism and the Soviet productivist economy. While historical scholarship rarely explores the intellectual context in which the Soviet experiment unfolded, ecomarxists tend to describe the Soviet Union’s mistaken path as a result of the loss of ‘metabolic’ thinkers following the rise of Stalin. This article challenges the neat, purported divide between a ‘metabolic’ and ‘productivist’ Marxism by analysing the energy-economic thinking of Gleb M. Krzhizhanovskii, a Bolshevik engineer and old friend of Lenin. As chairman of both the electrification commission (GOELRO) and the State Planning Commission (Gosplan), Krzhizhanovskii conceptualised the energy economy as something embedded in the metabolism of nature and society and as the technical-economic basis of the socialist economy. This argument drew its strength from his idea that production is part of the general, ongoing life-process, and the hope that large-scale electrification and electro-chemistry could help govern the metabolism between nature and society more rationally – both arguments commonly found among contemporary natural scientists. Any ecomarxist attempt to recover the concept of metabolism today has to come to terms with its productivist and technocratic history.
The Truth within a Circle: A Muḥabbaẓūna’s Play and Its Revival by Alfred Faraǧ
Authors: Potenza Daniela
Published: June 2021

During his travels in Egypt, Edward William Lane attended “a low and ridiculous farce,” he reports, performed by the muḥabbaẓūna, before Muḥammad ʿAlī Bāšā. Lane described its plot and concluded that the farce was played before the Pasha to open his eyes to the conduct of the tax collectors. When recounting farces in the Ottoman Empire, some travellers and critics confirm the narrative of ridiculous and low shows, while others underline their social critique. In 1979, inspired by Bertolt Brecht, Alfred Faraǧ rehabilitates the show in Dāʾirat al-tibn al-miṣriyya, masraḥiyyat al-muḥabbaẓīna (The Egyptian Hay Circle, a Play by the Muḥabbaẓūna). Comparing different descriptions of the muḥabbaẓūna and Faraǧ’s interpretation of their play, this paper provides reflections on the social aim of performances using the circle as an ephemeral division of fiction from reality and highlights how the muḥabbaẓūna could deliver political comments both to the common people and to the elites.
Old Arabic Minutiae I: ḥattā, laysa, and More from the Inscriptions of the Syro-Jordanian Ḥarrah
Authors: Al-Jallad Ahmad
Published: June 2021

This is the inaugural paper of a series on material attested in ancient North Arabia inscriptions that is of particular importance to the history of Arabic, its linguistic context, and its development and classification. The article edits eleven Safaitic inscriptions, inscribed on seven stones, discovered during the 2019 Badia Survey in Northeastern Jordan. Most of these texts attest new grammatical and lexical features that shed important light on this shadowy phase of Arabic’s pre-Islamic history, including attestations of the subordinating particle ḥt (= ḥattV), the negator ls (= laysa), possible nūnation, and idioms that appear later in the Qurʾān, e.g. tmny h-mt ‘he wished for death (in combat)’ (cf. Qurʾān tamannūna l-mawta).
Did the Syriac Translators of the Old Testament Peshitta Regard ‮ܫܡܝܐ‬‎ as Singular or Plural?
Authors: Lund Jerome A.
Published: June 2021

In recent literature, the noun ‮ܫܡܝܐ‬‎ has been described as a singular in the book of Isaiah, ostensibly on the basis of the lack of syame. I will argue to the contrary, demonstrating that it should be described as a plural in this corpus. The key to proper interpretation of the form is agreement with other clausal and phrasal constituents, not the presence or absence of syame.
General Principles of Procedural Law in the Practice of the WTO Appellate Body
Authors: de Andrade Mariana Clara
Published: June 2021

The method of identification of general principles and their function as a source of law have long been object of doctrinal debate. This topic is now under the programme of work of the International Law Commission. Relatedly, international courts and tribunals have relied on general principles of procedural law derived from national legal systems in their practice and reasoning, but the methodology employed by adjudicators in importing these sources from domestic law remains obscure. This research examines the use of general principles of procedural law in WTO dispute settlement, in particular by its Appellate Body. The aim is two-fold: first, to study the methodology employed in the identification of general principles of procedural law in the case law of the WTO Appellate Body; second, to examine the functions performed by general principles in the practice of this international jurisdiction.
‘The Girl Who Was Chased by Fire’: Violence and Passion in Contemporary Swedish Fascist Fiction
Authors: Gardell Mattias
Published: July 2021

Fascism invites its adherents to be part of something greater than themselves, invoking their longing for honor and glory, passion and heroism. An important avenue for articulating its affective dimension is cultural production. This article investigates the role of violence and passion in contemporary Swedish-language fascist fiction. The protagonist is typically a young white man or woman who wakes up to the realities of the ongoing white genocide through being exposed to violent crime committed by racialized aliens protected by the System. Seeking revenge, the protagonist learns how to be a man or meets her hero, and is introduced to fascist ideology and the art of killing. Fascist literature identifies aggression and ethnical cleansing as altruistic acts of love. With its passionate celebration of violence, fascism hails the productivity of destructivity, and the life-bequeathing aspects of death, which is at the core of fascism’s urge for national rebirth.
The Civil Code of Ukraine – A Reliable Regulator of Civil Relations in Civil Society
Authors: Kuznietsova Nataliia S. , Petryshyn Oleksandr V. , Pylypenko Denys S.
Published: June 2021

This article is a study of the Civil Code of Ukraine as the main regulator of civil relations in civil society. The history of adoption of the Civil Code of Ukraine and its conceptual foundations were reviewed. Particular attention is paid to the problem of dualism of private law in Ukraine. The structure and content of the Civil Code of Ukraine were analysed. Attention is also paid to the main novelties of the Civil Code of Ukraine. The principal rules for the regulation of legal entities were analysed. Novelties in defining the object composition of civil legal relations are considered. Particular attention is paid to the main directions of modern scientific research in the field of the civil law of Ukraine. The study confirms the urgent need for a thorough recodification of the Ukrainian civil law, with mandatory consideration of the experience of the implementation of modern recodifications in many European countries.
Convergence of the Contract Law of Ukraine and EU Member States
Authors: Luts Volodymyr V. , Hryniak Andrii B. , Pleniuk Mariana D. , Krykoves Valeriia V.
Published: June 2021

The purpose of the article is to analyse the modern contract law of Ukraine, which requires convergence with the provisions of the contract law of the countries of the European Community. The paper uses general scientific and special legal methods of scientific knowledge of private-law relations. The leading method of investigation of this issue is the modelling technique. In general, the issues of contractual regulation of private-law relations both in European Union law and in Ukraine are primarily addressed in terms of enhancing the role of the contract and shifting the emphasis from the statutory to individual regulation; strengthening the tendencies of the better legal protection of the interests of the weak side of the contractual obligation. Attention is drawn to the necessity of the introduction of a European methodology of binding law, which is reflected in the need for a combination of new and already known effective legal structures.
Implementation of the Right to Inheritance: Problems of Theory and Practice
Authors: Bychkova Svitlana S. , Bilianska Nataliia V. , Fedosieieva Tetiana R.
Published: June 2021

The article is devoted to the research into problematic aspects of exercising the right of inheritance by different categories of entities. As a result of the research conducted, recommendations for improvements to Ukrainian legislation have been developed. The status of a child born after 10 months and as a result of the use of assisted reproductive technologies after the death of one spouse should be determined at the legislative level. It also would be expedient in the Civil Code of Ukraine to fix the testator’s rights to settle the issue of birth of his children in the will through the use of assisted reproductive technologies after his death and to appoint such children as heirs. In addition, the Civil Code of Ukraine should provide for the possibility of individuals recognised as missing, to be heirs, and to secure the right to have a guardian over the property of such persons.
The many-rooted earthball—Scleroderma geaster and S. polyrhizum revisited, with the description of a new species
Authors: ORTIZ-RIVERO JAVIER , WATLING ROY , GUZMÁN-DÁVALOS LAURA , MARTÍN MARÍA P.
Published: July 2021

Scleroderma (Order Boletales, Basidiomycota) species have a worldwide distribution. In this study, we review the Scleroderma polyrhizum/S. geaster complex. Eighty-two specimens from different geographic origins were analysed using morphological, mainly basidiospore size and ornamentation, and molecular characters (ITS nrDNA). Our results showed a clear separation of the specimens into four clades and each clade could be distinguished with morphological characters. Thus, European specimens grouped into two clades with those considered to be S. geaster distinct from those considered S. polyrhizum. Many specimens from the USA under the name S. polyrhizum correspond to S. texense or to a new species, here described as S. guzmanii. This study demonstrated the importance of the molecular DNA barcode ITS in genetic analyses to reveal and identify cryptic species in fungal morphospecies.
Taxonomy of Geodia and Rhabdastrella from the Brazilian coast: a new species, new synonyms and redescription of Geodia tylastra (Demospongiae: Astrophorina: Geodiidae and Ancorinidae)
Authors: ALMEIDA DANILO S. , SANDES JOANA , GUIMARÃES CARMEN R. P. , MURICY GUILHERME
Published: June 2021

In this contribution we revise the type specimens of Geodia tylastra, Rhabdastrella fibrosa and Geodia corticostylifera, adding new photographs of preserved specimens, skeleton sections, and scanning electron micrographs of the spicules. We demonstrate that the three species are synonyms, with priority to the older name G. tylastra Boury-Esnault, 1973. We also show that Rhabdastrella fibrosa sensu Van Soest (2017) differs from the holotype in spicule composition and is here given a new name, Rhabdastrella vansoesti sp. nov. In addition, we describe a new species of Geodia, G. polytriaena sp. nov., and new records of G. glariosa and G. tylastra from Sergipe State, in the Northeast Brazilian coast. With the description of Geodia polytriaena sp. nov. and the synonymyzation of G. corticostylifera, 20 species of Geodia are now known in the Tropical Western Atlantic Ocean.