bluuebunny/crossref_metadata_2025 huggingface dataset:
Metastatic pituitary lesion
Authors: Lapshina A. M. , Bazarova E. A. , Przhialkovskaya E. G. , Khandaeva P. M. , Azizyan V. N. , Grigoriev A. Yu. , Ivashchenko O. V. , Tarbaeva N. V. , Belaya Zh. E.
Published: November 2024

Metastatic lesion of pituitary is a rare condition and is diagnosed in 1.8–4% of cases. Monitoring and treatment of such patients is a complex task and requires increased attention from a multidisciplinary team of specialists. The authors represent three patients with metastatic pituitary lesion who underwent neurosurgical treatment at the National Research Center of the National Research Institute of Endocrinology with subsequent pathomorphological confirmation of the diagnosis. The primary tumors were breast cancer, lung carcinoid, and clear cell kidney cancer. Two patients had distant metastases other than the pituitary gland. The clinical manifestation consisted in the appearance of symptoms of panhypopituitarism, chiasmal syndrome and mass effect in all cases. The follow-up period after surgical treatment was 0.25–2.5 years. Progression of the underlying disease was noted in two patients. One of them carried out stereotactic radiosurgical treatment and stereotactic oriented irradiation. One patient has a stable condition.
Insulin level, glycemia, insulin resistance and β-cell function in relation to the lifestyle of Arctic indigenous people. Are there conditions for diabetes and which type?
Authors: Strelkova A. V. , Bichkaeva F. A. , Vlasova O. S. , Nesterova E. V. , Shengof B. A. , Gretskaya T. B.
Published: November 2024

BACKGROUND: Modern studies suggest that lifestyle changes of the indigenous Arctic residents lead to the loss of the “adaptive polar type of metabolism”, which is characterized by the intensification of protein metabolism, optimization of lipid metabolism, and minimization of carbohydrate metabolism at low insulin concentrations. How to survive the era of change?

AIM: To assess insulinemia, glycemia, β-cell secretory activity, and insulin sensitivity in Arctic indigenous people in relation to their lifestyle.

MATERIALS AND METHODS: A cross-sectional study of a population of indigenous Arctic residents (Nenets, Komi) aged from 22 to 60 years was conducted. Insulin levels were studied in blood serum using ELISA, and glucose levels using the spectrophotometric method. Insulin resistance (HOMA-IR) and β-cell function (HOMA1-%β) indices were calculated.

RESULTS: 397 people were examined; 89 (22%) of them were nomadic people (NP) and 44 (49%) were male. Another 308 (78%) were sedentary people (SP), and 69 (22%) were male. The insulin level was significantly lower in NP (6.0 [3.5–11.8] µU/ml) compared to SP (8.3 [4.6–13.1] µU/ml), p=0.006. There was no difference in glycemia (4.6 [4.2–5.0] in NP and 4.6 [4.1–5.2] in SP) between lifestyles.

The HOMA-IR was significantly lower in NP (1.3 [0.7–2.4]) than in SP (1.8 [0.95–2.8]), p=0.013. IR-HOMA >2 units was 1.8 times more frequent in the SP than in NP, with adjusted for sex, age, and BMI OR=0.56; 95% CI: 0.33–0.96, p=0.034. The median HOMA1-%β was 128 [67–241] % in NP and 144 [93–236]% in SP with no significant differences between groups. The proportion of individuals with HOMA1-%β <48.9 was 17% in NP versus 5% in SP, p<0.001. The adjusted odds of having HOMA1-%β <48.9 in NP are 3.5 times higher than in SP; 95% CI: 1.56–7.92, p=0.002. Fifty-six cases of glycemia ≥5.6 mmol/l were identified: 13.5% in NP and 14.3% in SP. The ratio IR-HOMA >2/ HOMA1-%β <48.9/BMI was 1.8 units/45%/25.2 kg/m2 in NP and 3.0 units/88%/29.6 kg/m2 in SP.

CONCLUSION: Maintaining a nomadic lifestyle helps keep lower insulin concentrations; at the same time, glycemic levels in the groups were similar. In the NP group, there was a high proportion of individuals with low β-cell secretory activity, predominantly men; in the SP group, more individuals were insulin-resistant. Analysis of cases of glycemia ≥5.6 mmol/l confirmed, that hyperglycemia in a nomadic lifestyle was associated with β-cell hypofunction and the absence of obesity; on the contrary, in a sedentary lifestyle, it was associated with increased insulin resistance and obesity.
Cephalgic syndrome in patients with acromegaly
Authors: Nurullina G. N. , Pushkarev I. N. , Przhiyalkovskaya E. G.
Published: November 2024

The aim of this review is to summarize the data available in the literature on the causes of headache in patients with acromegaly, as well as on the effect of various methods of acromegaly treatment on headache. Publications were searched in the PubMed database using the keywords «Headache in patients with acromegaly», «Headache in patients with pituitary adenomas», «Tension-type headache», «Migraine». Headache in patients with pituitary adenomas secreting somatotropic hormone (STH) is not uncommon: according to various authors, cephalgic syndrome occurs in 30–70% of patients with acromegaly and can worsen their quality of life, along with other factors, up to disability. By the nature of development, headache with acromegaly is classified into primary (migraine, tension headache, trigeminal autonomic cephalgia, for example, SUNCT syndrome and cluster headaches), and can also be caused by various causes directly related to the tumor. All this requires differential diagnosis. The factors causing headaches in somatotropinomas have not yet been well studied and require further research. These include the mass effect of the tumor, hormonal hypersecretion, pathology of the temporomandibular joint, sodium and fluid retention in the body, psychological factors, etc. The authors evaluated the effect on headache of various methods of acromegaly treatment: transnasal transsphenoidal adenomectomy, radiation therapy and drug therapy with somatostatin analogues, dopamine agonists and growth hormone receptor antagonist. However, even when normal levels of STH and insulin-like growth factor 1 (IGF-1) are reached, cephalgic syndrome may persist, therefore patients should be warned about this in advance and referred to a cephalgologist to select adequate headache therapy.
Transformando a Educação Ibero-americana: políticas, práticas e tecnologías para a diversidade
Authors: Bizelli José Luis , Martín Bris Mario , Catalán Cueto Juan Pablo
Published: November 2024

Ao apresentar o livro Transformando a Educação na Iberoamérica: Políticas, Práticas e Tecnologias para a Diversidade para o público que estuda Educação, trazemos um conjunto de capítulos elaborados por pesquisadores que vêm trabalhando conjuntamente há 18 anos. De um convênio inicial entre a Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp) e a Universidade de Alcalá de Henares (UAH), outras Instituições de Ensino Superior iberoamericanas foram se agregando, construindo e adensando um espaço de diálogo para diferentes interpretações sobre as mais variadas práticas educativas, consolidando uma ideia da Escola que vem se desenvolvendo na região. Nesses 18 anos de trocas intelectuais, portanto, formulamos um pensamento Iberoamericano sobre a Educação Escolar, sistematizado em mais de 30 livros publicados pelo grupo.
Transformació Digital de l’Educació a l’Era de la Intel·ligència Artificial: Una Revolució Imparable
Authors: Valls Bautista Cristina , Holgado Garcia Josep , Marqués Molías Luis , Usart Rodríguez Mireia
Published: November 2024

La transformació digital impulsada per la intel·ligència artificial (IA) està redefinint l’educació amb oportunitats i desafiaments. La IA facilita l’aprenentatge personalitzat, identificant necessitats específiques de l’alumnat i alliberant els docents de tasques repetitives, mentre els tutors virtuals donen suport continuat. Tanmateix, en aquest volum, i fruit de les aportacions pràctiques al congrés FIET 2024, es plantegen reptes com la bretxa digital, la privacitat de les dades i l’impacte emocional de la tecnologia. A més, també es comparteixen propostes com la gamificació i l’adaptació dels entorns d’aprenentatge (físics i virtuals) busquen millorar la motivació, les habilitats pràctiques i el treball col·laboratiu. Finalment, en l’àmbit professional, compartim aportacions sobre com la IA pot millorar la gestió del talent i la formació personalitzada.
Erosion control ecosystem service provided by Salix acutifolia Willd. Neophyte on the South Baltic coast: Insights from Wolin Island, Poland
Authors: Borysiak Janina , Czyryca Paweł , Stępniewska Małgorzata
Published: November 2024

Further global warming is projected to increase coastal erosion. Therefore, coastal protection is being intensified with a strong emphasis placed on environmental biotechniques. One such activity is anti-erosion planting using alien plant species. The aliens penetrate from the plant species into the natural ecosystems, reducing their biodiversity and ecosystem services. Parallel to coastal protection, measures for nature conservation are undertaken to eliminate invasive aliens from the natural ecosystems that take over. Such actions are featured in the master plans drafted for the Natura 2000 sites on the south Baltic coast. Although there is no sufficient scientific evidence, Salix acutifolia willow used in anti-erosion plantings was considered a neophyte invading white and grey dune habitats and reducing their biodiversity. The master plans mandated the elimination of the willow without considering the role of its spontaneous locations in providing erosion-control services. In 2017–2023, research was undertaken on the south Baltic coast (Wolin Island) on the arguments behind such a radical conservation action. We present the results of these studies. We consider the elimination of S. acutifolia from its spontaneous locations as a reduction in both its erosion-control services and the willow’s role in nature conservation. We present some principles for action in case of a conflict between coast protection and nature conservation.
Mediathek Zeitgeschichte online – Nutzung digitaler Sicherungskopien audiovisueller Medien
Authors: Drews Marc , Stumpf Markus
Published: November 2024

In der Mediathek Zeitgeschichte online wird als Ergebnis eines Projektes ein Teilbestand der an der Fachbereichsbibliothek Zeitgeschichte der Universitätsbibliothek Wien vorhandenen audiovisuellen Medien unter Beachtung der österreichischen urheberrechtlichen Voraussetzungen in Form digitaler Sicherungskopien zur Nutzung bereitgestellt. In diesem Beitrag wird über die Umsetzung berichtet und die Mediathek Zeitgeschichte online vorgestellt.
Falso valor de HbA1c debido a la variante inusual hemoglobina Petie Salpetriere coheredada con talasemia alfa
Authors: Lepe Balsalobre Esperanza , Varo Sánchez Gema María , Rico Rodríguez Marta , Fuentes Cantero Sandra
Published: November 2024

Objetivos

Describir la variante de hemoglobina que interfiere en el análisis de HbA1c mediante HPLC de intercambio catiónico.

Caso clínico

Paciente de 78 años que acude a consulta de Medicina Interna para una revisión rutinaria, donde se incluye la determinación de HbA1c para la detección de diabetes. El paciente presenta como antecedentes hipertensión y dislipidemia sin presentar síntomas previos sugestivos de diabetes como hiperglucemia, pérdida de peso, polidipsia, poliuria o cansancio. La prueba de detección de la diabetes se realizó mediante determinación de la HbA1c con una columna de HPLC de intercambio catiónico y un analizador de inmunoensayo en el lugar de la asistencia (point of care). En la prueba rutinaria de detección de hemoglobinopatías se incluyó un hemograma completo, así como la determinación de HbF y HbA2 mediante HPLC de intercambio catiónico y electroforesis capilar (EC). La caracterización de variantes se realizó mediante secuenciación de ADN. Los resultados de HbA1c obtenidos fueron discordantes, la técnica HPLC de intercambio catiónico mostró una elevación de HbA1c de 52 mmol/mol, y el inmunoensayo mostró un nivel normal de 34 mmol/mol. La forma anormal del pico de HbA1c en el cromatograma motivó la realización de la prueba de detección de hemoglobinopatías para investigar la posible interferencia de variantes. Así, se realizó un análisis del gen de la globina, cuyos resultados revelaron la presencia de una variante de hemoglobina llamada “Hb Petie Salpetriere”. Esta variante surge de una sustitución Val→Phe resultante de una mutación de c.103G>T del gen de la beta-globina [BETA34 (B16) Val>Phe; HBB:c.103G>T]

Conclusiones

Se trata del primer caso de detección de la variante Hb Petie Salpetriere en un paciente español. Los resultados obtenidos indican que la variante Hb Petie Salpetriere puede interferir en los resultados de los análisis de HbA1c realizados mediante HPLC de intercambio iónico, no ocurriendo lo mismo con el método de inmunoensayo de aglutinación de látex. Únicamente el HPLC de intercambio iónico reveló la presencia de la variante de la Hb en este caso, lo que indica que se puede detectar una posible variante mediante una revisión meticulosa del cromatograma.
How has the external quality assessment/proficiency testing of semen analysis been developed in the past 34 years: a review
Authors: Zheng Yan , Wu Yingbi , Yu Lin , Jia Yelin , Yang Tingting , Cheng Qingyuan , Qin Jiao , Liu Xiao , Jiang Min , Li Fuping
Published: November 2024

Male infertility has become an important issue of global concern. Semen analysis is the cornerstone of male fertility assessment. External quality assessment (EQA) of sperm concentration, motility, and morphology is widely recognized in the world. However, over the past 34 years, the implementation of EQA for semen analysis has varied across different countries, and there is no global consensus. The goal of this paper is to first explore the overall development of EQA during this period. Secondly, it aims to discuss the extent of difference of participating laboratories in different countries. Finally, the paper examines the differences in EQA programs developed by various EQA providers in order to seek a global standard. In total, 29 papers met the inclusion criteria and were included in this review. There is inconsistent in the implementation of EQA across different countries, and there is no global consensus. Policies for EQA of semen analysis vary from country to country. Some countries mandate laboratory participation, while others permit voluntary involvement. Different EQA organizers choose different ways to calculate assigned value and acceptance limits. The coefficient of variation (CV) for each EQA item was large. The CVs of concentration, motility, morphology, and viability were 12.7–138.0 %, 17.0–127.0 %, 7–375 %, and 6–41.1 %, respectively. The results of the semen analysis varied considerably among the participating laboratories. The collaborative efforts of national policymakers, EQA organizers, and all participating laboratories are essential to improving the current situation.
Friend or Foe? A Mixed-Methods Study on the Impact of Digital Device Use on Chinese–Canadian Children’s Heritage Language Learning
Authors: Li Guofang , Mei Ziwen , Zhen Fubiao
Published: November 2024

Digital devices have been increasingly integrated into language learning environments, particularly since the COVID-19 pandemic. Existing literature, focusing predominantly on dominant languages like English, presents mixed findings on the effectiveness of digital resources for language learning. Few studies address heritage languages, which often have limited resources beyond the home and may depend more on digital tools for support. This longitudinal, mixed-methods study investigated the impact of digital device use on heritage language learning among Chinese–Canadian families. We examined the relationship between digital device use and Chinese receptive vocabulary among 128 first graders, 137 second graders, and 66 third graders over three years. Additionally, we conducted parental interviews with 42 focal families for three years to explore the evolving patterns of digital resource use at home. Our findings revealed a statistically significant positive impact of digital device use on Chinese receptive vocabulary development among first and second graders, while no significant effects were observed in third graders. The analyses of parental interviews uncovered increased digital use, diversity of resources, positive parental attitudes, and digital literacy among families from grades 1 to 2 but decreased digital use and parental enthusiasm in the third grade due to health and addiction concerns, reinforcing the quantitative results. Conducted during the COVID-19 pandemic, this study offers a unique perspective on how families’ digital device use for heritage languages changed before, during, and after the pandemic. The findings offer valuable insights for families and educators to better support heritage language learners with digital resources.
A Novel Perspective on Prioritizing Investment Projects under Future Uncertainty: Integrating Robustness Analysis with the Net Present Value Model
Authors: Shao Sheng , Sorourkhah Ali
Published: November 2024

Investment decisions are important because they involve significant capital in a business. According to the literature, experts agree that a net present value (NPV) approach is better suited for evaluating investment projects’ feasibility. Practically, the NPV method does not account for uncertainty in calculating the expected return on investment. Investments may be susceptible to random events such as natural disasters or economic instability that hinder the expected return on investment. While previous research has attempted to address uncertainty using fuzzy approaches, these approaches mainly focus on data-centric uncertainty. The focus of this study is on the uncertain environmental conditions where changes in macroeconomic, political, and other indicators can influence decision outcomes. This study conceptualizes and implements combining the NPV approach with robust analysis as an efficient and practical method in decision-making under uncertainty and unpredictability. The proposed algorithm was implemented in a case study on investment project selection in Tannakabon, Iran. The results indicate that considering future scenarios, the restaurant investment project is the most suitable among the seven projects. In contrast, the cafe investment project is the least appropriate option available.
Camera trapping reveals the reddish phenotype of jaguarundi (Herpailurus yagouaroundi) on the western border of Brazilian Pantanal
Authors: Porfírio Grasiela , Queiróz Mariana , Tonolli Geovani , Arruda Moreno Wener Hugo , Barreto Sergio Eduardo , Cardoso de Lima Paula , Guerra Angélica , Kellermann Betina , Oliveira Josiel , Passos Viana Diego Francis
Published: November 2024

The jaguarundi is one the least studied felids in South America. With its three main forms (brownish-black, grey and reddish), the species is listed as Least Concern by the IUCN, but is Vulnerable in Brazil. The grey form is the most common, and has been recorded at several sites within the Pantanal biome, but not the reddish form so far. In this study we report the reddish phenotype for the first time in the biome. Records were obtained from November 2022 through camera traps in Acurizal Reserve. Reports like this are important to understand the evolutionary processes affecting the species over time.
Structural monitoring of elevator guide rail bracket under normal running condition
Authors: Baran Muhammet İsmail , Onur Yusuf Aytaç
Published: November 2024

In parallel with the need for high-rise building structures over the last five decades, challenge in the field of elevator technology has increased. Elevator facilities are one of the most important mechanical systems among the vertical transport systems that have vast variety of usage areas. Guide rails and connection equipment are used to guide the vertical movement of elevators, prevent horizontal movement, and help to stop cabin in case of emergency. The state of stresses and deformations in guide rails and their brackets that perform different and important tasks and their association with elevator safety is a very important issue that needs to be investigated. In this study, three different load distributions that result in forces, stresses, and deflections on guide rail and rail brackets have been considered to attain analytical solutions described in related standards. Finite element modeling and stress analysis of guide rail connection system have been performed. In addition, experimental studies were carried out to measure the normal stresses on the guide rail brackets during the movement of the elevator. About 15.46 % higher experimental normal stress values were observed on the rail bracket during the movement of the elevator in accordance with FEA results.
Influence of SiC content on the properties of Al/SiC composites produced by powder metallurgical route
Authors: Bayrak Yahya
Published: November 2024

In this study, Al/SiC composites were produced by hot pressing and the properties of the fabricated samples were investigated. The composites were produced at 5 wt.%, 10 wt.% and 15 wt.% SiC ratios. The hot pressing process was carried out at 550 °C for 30 min with 65 MPa. The properties of the samples were characterized by microstructure analysis, wear and corrosion tests. It was revealed that a higher reinforcement ratio caused the clustering of SiC particles. On the other hand, wear rate and corrosion resistance of the composites were improved with SiC reinforcement. The wear rate of the aluminium was determined as 21.82·10−4 mm3·Nm−1. The wear rate decreased to 0.69·10−4 mm3·Nm−1 with 15 wt.% SiC ratio. Moreover, the corrosion rate of the aluminium was reduced from 0.1247 mm/year to 0.0932 mm/year with 15 wt.% SiC. In conclusion, it has been revealed that SiC reinforcement improves the wear and corrosion properties of aluminium.
Das Projekt „Qualität und Qualitätsentwicklung im Religionsunterricht“ (QUIRU) – Bedeutung für die Praxis und das Theorie-Praxis-Problem empirischer Unterrichtsforschung
Authors: Schweitzer Friedrich
Published: November 2024

Den Ausgangspunkt dieses Beitrags stellt das bei dem Projekt „Qualität und Qualitätsentwicklung im Religionsunterricht“ identifizierte Problem dar, dass Befunde aus der empirisch-religionspädagogischen Unterrichtsforschung die Praxis nicht zu erreichen scheinen. Vor diesem Hintergrund wird das Projekt QUIRU mit seinen Teilprojekten (Untersuchungen zur Ausbildung und Fortbildung für den Religionsunterricht, Erhebungen zur Unterrichtsqualität) kurz vorgestellt, mit ausgewählten Befunden zur Wahrnehmung von Religionsunterricht durch die Schüler:innen und zu ihrem Lernerfolg, zum Thema andere Religionen sowie zum Verhältnis zwischen Glaube und Naturwissenschaft. Darüber hinaus wird nach der Bedeutung solcher Befunde für die Praxis gefragt. Am Ende stehen Überlegungen dazu, wie solche Befunde in Zukunft die Praxis besser erreichen können.
Ventral Pallidum Neurons Are Necessary to Generalize and Express Fear-Related Responding in a Minimal Threat Setting
Authors: Russell Emma L. , McDannald Michael A.
Published: November 2024

Fear generalization is a hallmark of anxiety disorders. Experimentally, fear generalization can be difficult to dissociate from its counterpart, fear discrimination. Here, we use minimal threat learning procedures to reveal such a dissociation. We show that in Long–Evans rats, an auditory threat cue predicting footshock on 10% of trials produces a discriminated fear response that does not generalize to a neutral auditory cue. In contrast, even slightly higher footshock probabilities (30 and 20%) produce fear generalization. AAV-mediated, caspase-3 deletion of ventral pallidum neurons abolishes fear generalization and reduces threat cue responding during extinction. The ventral pallidum's contribution to fear generalization and extinction threat responding does not depend on inputs from the nucleus accumbens. The results demonstrate a minimal threat learning approach to dissociate fear discrimination from fear generalization and a novel role for the ventral pallidum in generalizing and expressing fear.
Encoding of Global Visual Motion in the Avian Pretectum Shifts from a Bias for Temporal-to-Nasal Selectivity to Omnidirectional Excitation across Speeds
Authors: Dash Suryadeep , Baliga Vikram B. , Lapsansky Anthony B. , Wylie Douglas R. , Altshuler Douglas L.
Published: November 2024

The pretectum of vertebrates contains neurons responsive to global visual motion. These signals are sent to the cerebellum, forming a subcortical pathway for processing optic flow. Global motion neurons exhibit selectivity for both direction and speed, but this is usually assessed by first determining direction preference at intermediate velocity (16–32°/s) and then assessing speed tuning at the preferred direction. A consequence of this approach is that it is unknown if and how direction preference changes with speed. We measured directional selectivity in 114 pretectal neurons from 44 zebra finches (Taeniopygia guttata) across spatial and temporal frequencies, corresponding to a speed range of 0.062–1,024°/s. Pretectal neurons were most responsive at 32–64°/s with lower activity as speed increased or decreased. At each speed, we determined if cells were directionally selective, bidirectionally selective, omnidirectionally responsive, or unmodulated. Notably, at 32°/s, 60% of the cells were directionally selective, and 28% were omnidirectionally responsive. In contrast, at 1,024°/s, 20% of the cells were directionally selective, and nearly half of the population was omnidirectionally responsive. Only 15% of the cells were omnidirectionally excited across most speeds. The remaining 85% of the cells had direction tuning that changed with speed. Collectively, these results indicate a shift from a bias for directional tuning at intermediate speeds of global visual motion to a bias for omnidirectional responses at faster speeds. These results suggest a potential role for the pretectum during flight by detecting unexpected drift or potential collisions, depending on the speed of the optic flow signal.
Registered Report: Self-Control Beyond Inhibition—German Translation and Quality Assessment of the Self-Control Strategy Scale (SCSS)
Authors: Roth Leopold H. O. , Jankowski Julia M. , Meindl Dominik , Clay Georgia , Mlynski Christopher , Freiman Olga , Nordmann Artemis L. , Stenzel Loana-Corine , Wagner Victoria
Published: November 2024

Self-control is crucial for goal attainment and related to several beneficial outcomes, such as health and education. For a long time, it was predominantly understood in terms of inhibition, namely the ability to suppress immediate urges for the sake of long-term goals. Still, research on other self-control strategies has a longstanding tradition and recent research has moved towards a broader approach, integrating different strategies of self-control (e.g., reappraisal or pre-commitment) to gain a more comprehensive perspective on relevant processes in goal protection. The current study aimed to translate and validate the Self-Control Strategy Scale (SCSS, Katzir et al., 2021) to enable its application in German speaking populations while assuring high measurement quality. Across 5 studies (N = 3,400), we assessed the internal structure, reliability and convergent and discriminant validity. Additionally, the strategies’ relationship with several self-control outcomes (e.g., achievement, health behavior, or pro-environmental behavior) were tested. The assumed eight-factor structure was confirmed, internal consistency and retest reliability were sufficient for most subscales and the model was invariant between gender and age groups. Convergent and discriminant validity were overall adequate. Different associations emerged between strategies and outcomes, depending on the outcome domain. Thus, the SCSS appears to be a valid and reliable measure, which can be used in German. The results provide a good starting point for future research on the utility of self-control strategies in different domains.
Validação do inquérito Conhecimento, Atitude e Prática para o autocuidado em hanseníase
Authors: Gomes Charmenes Alves , Lopes Maria do Socorro Vieira , Alves Sabrina Alaide Amorim , Maia Evanira Rodrigues , Cavalcante Edilma Gomes Rocha , Lima Cynthia Kelly Fernandes de , Silva José Wagner Martins da
Published: November 2024

Objetivo:  validar o conteúdo do inquérito Conhecimento, Atitude e Prática de autocuidado em hanseníase. Métodos: estudo metodológico desenvolvido em duas etapas: elaboração do instrumento e validação do conteúdo por juízes especialistas. O conteúdo de cada item foi validado quanto à clareza. Utilizou-se o Índice de Validade de Conteúdo para avaliar a concordância entre os juízes. Para análise dos dados, foram usadas estatísticas descritivas. Resultados: participaram cinco especialistas, o índice de validade de conteúdo do inquérito foi de 0,87. Foram reformulados 21 itens, incluídos 11 e três foram acrescentados em outro domínio. Resultando em 40 itens distribuídos em três categorias: cuidados com a face (15 itens), mãos (12 itens) e pés (13 itens). Conclusão: a versão final do inquérito Conhecimento, Atitude e Prática contemplam as categorias de face, mãos e pés e alcançou validade de conteúdo adequada para sua utilização. Contribuições para a prática: consiste em um importante instrumento que auxiliará profissionais de saúde na tomada de decisões junto às práticas de promoção para o autocuidado de pessoas com hanseníase.
Legal Regulation Experience of Individual Countries of The European Region Regarding Implementation of International Standards for Ensuring Criminological and Criminal-Legal Protection of Justice
Authors: Khrystova Yuliia , Miroshnychenko Serhiy , Kurbatova Iryna , Titarenkо Oleksiy , Maksimentsev Maksym
Published: November 2024

The article describes experience of Germany and Austria in implementing international standards for ensuring criminological and criminal-legal protection of justice. A set of general scientific and specific scientific research methods were used in the preparation of this article in order to define special subjects authorized to carry out such criminological activities, peculiarities of their interaction with the police and other law enforcement agencies, to reveal the content of legislative mandates regarding organization and functioning of the Court Security Services and their counterparts, as well as that of the legislation on criminal liability for criminal offenses against justice. The purpose of this work is to determine promising directions for increasing efficiency of implementing criminological and criminal-legal protection of justice by authorized subjects in Ukraine, which has become especially important in the sphere of ensuring national security under martial law, taking into account positive experience of such European region countries as Germany and Austria regarding implementation of international standards recognized by the international community in this area. Based on the results of the research, prospective directions for improving the activity of the Court Security Service of Ukraine, its interaction with the National Police and other subjects of the state sector and non-state sector in provision of criminological protection of justice, as well as the legislation of Ukraine on criminal liability for criminal offenses against justice, taking  into account experience of Germany and Austria regarding implementation of standards recognized by the international community in this area.Key words: Criminological Protection of Justice; Court Security; Court Security Service; National Police of Ukraine; Criminal Offenses Against Justice.
Giovanni Maria Parenti utazása Mátyás király udvarába (1486). A humanista útinapló eredeti szövege és magyar fordítása
Authors: Kuffart Hajnalka
Published: November 2024

Giovanni Maria Parenti was a 15th-century humanist cleric who wrote a book on the life and miracles of Saint Geminianus, the patron saint of his native Modena. The book, decorated with colour engravings, was published in 1495, also in Modena. A lesser known detail of the author’s life is that in 1486 he was part of an embassy to Hungary and compiled a twelve-page travel diary of his journey from Venice to the Hungarian royal court. The original manuscript, preserved in the State Archives of Modena, is not in good condition. Much of the text is very difficult to read, but it is well worth the effort: the diary-like document is not simply a list of the places visited on the journey, but a colourful and eventful account of the experience, with scenes of humour, enthusiastic praise and sharp criticism. And the description of the Archbishop’s seat in Esztergom includes unique details that are rarely found in other sources: the large murals of the archiepiscopal castle, details of the portraits of kings, mainly known from Antonio Bonfini’s work, and the scene of the conquest of the Pannonian Basin by the Magyars. The study provides information on the origins of the document, analyses the content of the text, adds other sources to the story, and the appendix includes a Hungarian translation of Parenti’s travel diary alongside the original text.
The Philosophical Proofs of the Existence of God: It’s Implication for Christian Faith and Practice
Authors:   Africa International University, Karen, Nairobi, Kenya, Ndzi Leonard
Published: November 2024

The philosophical proof of the existence of God has been a central topic of debate throughout history, with various arguments put forth to support the existence of a higher being. This argument, such as the ontological, cosmological, and teleological arguments, aims to demonstrate that the existence of God can be logically inferred from the nature of the universe and human experience. The implications of these philosophical proofs for Christian faith and practice are profound. For Christians, the philosophical proof of God’s existence can strengthen their faith by providing rational justification for their beliefs. It can also deepen their understanding of God’s nature and attributes, leading to a more profound relationship with the divine. Additionally, these proofs can guide moral and ethical decision-making, as they provide a foundation for understanding the source of objective moral and ethical values. The philosophical proof of God’s existence can inspire believers to live out their faith more authentically and passionately. It can also foster a sense of awe and wonder at the complexity and beauty of the universe, leading to a deeper appreciation of God’s creation. Overall, the philosophical proof of the existence of God has the potential to enrich and enliven Christian faith and practice, offering believers a firm intellectual foundation for their spiritual journey.
The Essence of Salvation: Exploring Evangelical Perspectives And Practices
Authors:   Africa International University, Karen, Nairobi, Kenya, Ndzi Leonard
Published: November 2024

This article explores the core doctrines and practices of evangelical Christianity about salvation, highlighting the differences in viewpoints among evangelical theologians and believers. The theological tenets of salvation described are the idea of being “born again” and the significance of one’s faith in Jesus Christ. The idea that salvation is a life-changing event characterized by repentance and a deliberate choice to embrace Christ as Savior, resulting in a revitalized spiritual life, is fundamental to evangelical philosophy. The essay highlights contrasting opinions among evangelical circles regarding predestination, free choice, and the assurance of salvation as it further explores the roles of grace, faith, and works in salvation. Salvation-related customs, including baptism, altar calls, and public testimony, are addressed as manifestations of faith and social validation. It also examines the evangelical focus on evangelism as a moral obligation, with the need to spread the gospel to everyone. The article’s conclusion discusses the problems evangelical views of salvation are currently experiencing, particularly in light of social and cultural changes. It considers how these modifications may affect evangelical outreach and discipleship strategies.
From rifting to Indosinian orogeny recorded in the Indochina from late Devonian to late Triassic: a review
Authors: Luong Thi Thu Hoai , Nguyen Van Vuong , Faure Michel , Wei Lin , Vu Tien Thanh , Tran Thi Thanh Nhan , Nguyen Thi Minh Thuyet
Published: November 2024

The Indochina block, the most significant part of South East Asia, is bounded by the Ailaoshan-Song Ma suture zone in the north and Jinghong-Nan-Uttradit, Sra Kaeo suture in the west. These sutures result from the various tectonic events related to the rifting and closing of the Paleo-Tethys and successive collision of South China (Sino-Vietnam)-Indochina-Sukhothai arc-Sibumasu continental blocks. However, the timing of the commencement of the rifting eastern Paleo-Tethys, subduction, subsequent collision orogeny, duration of these stages, and their geodynamic mechanism remain controversial. Our review of the stratigraphic, sedimentary, magmatic, metamorphic, structural, and geochronological data available for the suture zones bounding and interior of the Indochina block indicate successive tectonic events from rifting through subduction to orogeny and provide new insights into the tectonic history from Late Devonian to Triassic that shape the Indochina block and its adjacent regions. The remnant of the Paleo-Tethys branch and deep marine cherts represented by the Ailaoshan-Song Ma and Nan-Uttaradit suture melanges record the rifting and oceanic crust formation stage at ~380-313 Ma and 316-310 Ma, respectively. The southwestward subduction of the South China block under the Indochina block resulted in the development of the magmatic arc at ~ 310-247 Ma in the north Indochina block; meanwhile, the subduction of the Sibumasu block below the Indochina gave rise to the Sukhothai magmatic arc and Jinghong-Nan-Luang Prabang-Loei back-arc basins in the western Indochina at ~278-235 Ma. The South China slab rollback may significantly affect arc magmatism distribution in the north Indochina block. The final closure of the eastern Paleo-Tethys resulted in Indosinian collision orogeny of the Indochina with South China blocks at ~250-230 Ma in the Ailaoshan-Song Ma suture, followed by the Sibumasu block with Indochina-South China continent at ~240-230 Ma in the Jinghong-Nan-Uttradit-Sra Kaeo sutures. The late to post-collisional orogeny occurred in the north and west Indochina at ~235-200 Ma and ~230-200 Ma, respectively.
Žurnalui „Sporto mokslas“ – 30 metų: praeitis, dabartis ir ateities perspektyvos
Authors: Milašius Kazys
Published: November 2024

Žurnalas „Sporto mokslas“ mini garbingą sukaktį – jis leidžiamas jau 30 metų. Per šį laikotarpį nueitas ilgas, sudėtingas raidos ir brandos kelias, kuris leidžia vadintis neatsiejama Lietuvos sporto mokslo dalimi. Šiuo metu Leidėjų tarybai vadovauja Vytauto Didžiojo universiteto Švietimo akademijos kanclerė prof. dr. Lina Kaminskienė ir Lietuvos olimpinės akademijos prezidentė prof. dr. Asta Šarkauskienė, žurnalo vyr. redaktorius – prof. habil. dr. Kazys Milašius. Skyrių atsakingųjų ir redaktorių tarybą sudaro 26 asmenys, iš kurių 16, arba 61,5 proc., yra įžymūs užsienio šalių sporto mokslininkai. Žurnalas referuojamas tarptautinėje duomenų bazėje Copernicus. Žurnalo „Sporto mokslas“ misija – skelbti naujausių, originalių Lietuvos ir kitų užsienio šalių įvairių mokslo sričių: socialinių, gamtos ir medicinos, fizinių, humanitarinių – mokslinių tyrimų rezultatus, skleisti naujausias žinias iš pasaulio, Europos sporto mokslo kongresų, simpoziumų, konferencijų, supažindinti su apgintomis sporto mokslo daktaro disertacijomis, monografijomis, padėti formuoti Lietuvos sporto mokslo strategiją. Per 30 žurnalo leidybos metų paskelbta 1330 straipsnių. Daugiausia publikacijų – 684 buvo paskelbtos socialinių mokslų srities problemoms nagrinėti. Žurnalo vertę rodantis rodiklis yra jame spausdinamų užsienio šalių autorių publikacijų kiekis. Jų yra 187, tai sudaro 14 proc. bendro jų skaičiaus. Apžvelgiant produktyviausių autorių straipsnius pagal atskiras sporto mokslo kryptis, galima pažymėti, kad Lietuvos sporto mokslo lyderiai yra prof. J. Skernevičius, prof. A. Skurvydas, prof. P. Karoblis, prof. A. Raslanas, prof. K. Milašius, prof. A. Skarbalius, prof. A. Poderys, prof. R. Dadelienė, prof. S. Poteliūnienė. prof. L. Tubelis.
Jaunųjų sportininkų brandos, miego įpročių ir augimo mąstysenos sąsajos
Authors: Paliulytė Dominyka , Kemerytė-Ivanauskienė Eglė , Ivanauskas Vidas
Published: November 2024

Paauglystė – vienas sudėtingiausių laikotarpių, kai jauno žmogaus organizme vyksta dideli fiziologiniai ir psichologiniai pokyčiai. Jei paaugliai siekia aukštų sportinių rezultatų, šių pokyčių indėlis dar didesnis, nes jaunieji sportininkai turi suderinti griežtą treniruočių režimą, sutelkdami dėmesį į optimalius sportinius rezultatus ir mokymąsi mokykloje, siekiant geresnių akademinių rezultatų. Moksliniai tyrimai parodė, kad jaunųjų sportininkų miego kokybė ir jo trukmė mažėja dėl įtemptų treniruočių grafikų, mokymosi, socialinių įvykių, kelionių ir kt. Prasta miego kokybė gali lemti dažnesnį traumų atsiradimą, pervargimą, prastesnę jaunųjų sportininkų fizinę ir psichinę sveikatą. Prastėjant paauglių psichinei sveikatai gali keistis ir jų augimo mąstysena, kuri skatina žmogų priimti iššūkius, atkakliai kovoti su nesėkmėmis ir nuolat siekti tobulėjimo, tikint galimybe keistis, ir yra glaudžiai susijusi su mokinių fiziologine branda. Tyrimo objektas – jaunųjų sportininkų miego įpročiai, branda ir augimo mąstysena. Tyrimo subjektas – 8–11 klasių paaugliai, besimokantys specializuotoje sporto gimnazijoje, kurioje sudarytos sąlygos jauniesiems sportininkams mokytis bendrojo lavinimo mokykloje ir treniruotis 2 kartus per dieną. Tyrimo metodai: literatūros šaltinių analizė; anketinė apklausa; kiekybinis tyrimas – apklausa raštu (anketa / klausimynas), skirta brandai, miego įpročiams ir paauglių augimo mąstysenai įvertinti. Statistinė tyrimo duomenų analizė atlikta pasitelkiant SPSS 27 versijos programą. Remiantis tyrimo duomenimis, padaryta išvada, kad sportuojantiems paaugliams yra labiau būdinga augimo mąstysena, kuri reikšmingai nesiskyrė nei lyties, nei klasių, nei brandos aspektu, tačiau jai įtakos turėjo miego įpročiai.
Identification of Glucose-6-Phosphate Dehydrogenase (G6PD) Inhibitors by Cheminformatics Approach
Authors: Mundla Srilatha , Saddala Madhu Sudhana
Published: November 2024

Glucose-6-phosphate dehydrogenase (G6PD) is an essential enzyme in the pentose phosphate pathway (PPP), a critical glucose metabolism pathway linked to cancer cell proliferation and metastasis. Inhibiting the PPP presents a promising approach to cancer treatment. The G6PD enzyme structure was obtained from the Protein Data Bank (PDB). The active site responsible for NADP+ binding was identified and used for structure-based pharmacophore design. This pharmacophore model was applied to the ZINC database to screen for small molecules. Molecular docking was accomplished using AutoDock Vina, and protein-ligand interactions were analyzed. Additionally, compounds were validated based on in silico ADMET properties to select the most promising candidates. A comprehensive screening and docking procedure identified several potential G6PD inhibitors. These compounds showed favorable interactions with the active site and met the criteria for optimal ADMET properties. The newly proposed G6PD inhibitors, with their potential to revolutionize cancer therapy, could serve as lead molecules for further research and development, inspiring the audience about the possibilities in cancer therapy.
Single and Multi-Objective Optimization of the Red Pine Mushroom Lactarius deliciosus (Agaricomycetes) Extraction Conditions Using Artificial Intelligence Methods and Biological Activities of Optimized Extracts
Authors: Gürgen Ayşenur , Sevindik Mustafa
Published: November 2024

In this study, the biological activities of Lactarius deliciosus were determined. Experimental studies were carried out using a soxhlet device, in the range of 40-70°C extraction temperature, 3-9 h extraction time and 0.5-2 mg/ ml extraction conditions. A total of 64 different extracts were obtained using four different values of each variable and the total antioxidant status (TAS) and total oxidant status (TOS) values of these extracts were determined. The obtained data were modeled using artificial neural networks (ANN). Both single-objective and multi-objective optimization processes were performed using the best ANN model selected among the established models. Single-objective optimization was performed with genetic algorithm (GA), and multi-objective optimization was performed using the Non-Dominated Sorting Genetic Algorithm (NSGA-II) algorithm. Extracts obtained from the extraction conditions suggested by the optimization algorithms were used for biological activities. As a result of the analyzes, TAS values of the single-objective optimization extract (1st) and multi-objective optimization extract (2nd) prepared under optimum conditions of the mushroom were determined as 7.468 ± 0.055 and 6.128 ± 0.049 mmol/L, TOS values were 13.161 ± 0.168 and 10.056 ± 0.106 μmol/L and OSI values were 0.176 ± 0.003 and 0.164 ± 0.003, respectively. It was found to be effective against bacterial and fungal strains at concentrations of 50-200 μg/mL. In addition, mushroom extracts were found to have strong cytotoxic effects against A549 cancer cell line. Acetylcholinesterase activity of the 1st and 2nd extracts of the mushroom were determined as 24.80 ± 0.82 and 32.71 ± 0.91 μg/mL, butyrylcholinesterase activity was determined as 51.24 ± 0.80 and 57.10 ± 0.51 μg/mL, respectively. In our study, it was determined that L. deliciosus extracts obtained under optimum conditions had strong biological activities.
Investigation into the flexural performance of novel precast sandwich wall panels
Authors: Dai Chunquan , Hou Mingfa , Huang Ming , Yu Haiyang
Published: November 2024

The paper focuses on investigating a novel sandwich panel, which incorporates extruded polystyrene foam boards placed between the inner and outer concrete panels. These are connected using various types of shear connectors to achieve a composite action, meeting the bending resistance requirements. To study the structural performance of the sandwich panels, three representative specimens were designed. These specimens employed different types of shear connectors, namely, steel truss connectors with inclined bars at 45°, and GFRP connectors with inclined bars at 45° and 30°, respectively. The specimens underwent full-scale testing using a step-by-step four-point loading method. The test results indicated shear-compression failure of the specimens, exhibiting consistent failure modes across all specimens, and a composite action in resisting bending moments. Based on theoretical stress–strain diagrams and considering the slip phenomenon between the concrete panel and the connectors, this paper establishes an analytical model. It can reasonably estimate the ultimate load-carrying capacity of sandwich insulation panels under shear-compression failure, which has implications for subsequent engineering applications.