bluuebunny/crossref_metadata_2025 huggingface dataset:
UNDERSTANDING EWOM INTENTIONS FROM APPROACH-AVOIDANCE PERSPECTIVE: A COMPREHENSIVE MODEL OF DESTINATION TRUST, SATISFACTION, AND LOYALTY
Authors: WAHYUDI Lilik , MAGHRIFANI Dila , FIBAYANI Alifah Faidurrohmah
Published: February 2025

Purpose – Using the dualistic perspective of Approach-Avoidance, this study aims to
determine tourists’ eWOM intentions by examining the relationship between ApproachAvoidance reactions, destination trust, and satisfaction. In particular, this study examines the
effects of Approach-Avoidance reactions on destination trust and satisfaction and thus their
effects on tourists’ eWOM intentions.
Methodology – An online survey was conducted among Indonesian tourists who visited
Pulau Komodo in Labuan Bajo, Indonesia. 333 valid responses were received. Analyses were
conducted using Structural Equation Modelling (SEM) with Partial Least Squares (PLS) to
test the study hypotheses to provide a comprehensive overview of relationships.
Findings – The results showed that tourists’ eWOM intentions were influenced by destination
satisfaction and destination trust. Further, approach reaction was found to have a positive
influence on destination satisfaction and destination trust. However, the results showed no
significant relationship between avoidance reaction and destination trust and satisfaction.
Originality of the research – This study enhances tourism literature in tourists’ eWOM
intentions through dualistic perspectives. It provides detailed insights into how eWOM
intentions are influenced by Approach-Avoidance reactions, destination trust, and destination
satisfaction, focusing on the context of Pulau Komodo in Indonesia
A Letter by M. Putsillo to Baron F. von der Osten-Sacken: the Finding in the Book
Authors: Vorobyeva N. V.
Published: February 2025

The author of the published letter, Mikhail Putsillo (1845–1889) was a researcher and an owner of entomological and mineralogical collections. He was famous as the first Russian scholar who specialized in Korean studies and a compiler of the Russian-Korean dictionary. The letter, addressed to the diplomat, scientist and politician, Baron Reinhold Friedrich Freiherr von der Osten-Sacken, contains some interesting information concerning the author’s work on the “Index of Cases and Manuscripts Related to Siberia” (1879). The edition was dedicated to the 300th anniversary of the accession of Siberia to Russia. The author also mentions the documents he found in the archive of the Ministry of Foreign Affairs (concerning the Age of Exploration discoveries made by Russian sailors in the second half of the 18th century in North America). The letter is pasted into the book belonged previously to Baron Friedrich Freiherr von der Osten-Sacken and is still stored at the Department of Rare Books of the Altai Regional Universal Scientific Library named after V. Ya. Shishkov.
Analisis Pola Interaksi Spasial Industri Batik Home Dress di Kampung Batik Kauman Kota Surakarta Tahun 2024
Authors: Bidari An-Nissara Putri , Rindarjono Mohammad Gamal , Prihadi Singgih
Published: February 2025

Kampung Batik Kauman merupakan kampung kuno yang memiliki nilai sejarah tinggi salah satunya berkaitan dengan industri batik. Pada tahun 2009 Pemerintah Kota Surakarta menetapkan Kauman sebagai Kampung Wisata Batik. Kehadiran sentra industry batik ini menjamin dihasilkannya batik dengan kualitas terbaik dan banyak diminati masyarakat luas. Penelitian ini memiliki tujuan untuk (1) Mengetahui persebaran industri batik home dress di Kampung Batik Kauman Kota Surakarta (2) Mengetahui karakteristik industri batik di Kampung Batik Kauman Kota Surakarta (3) Mengetahui pola interaksi spasial industri batik di Kampung Batik Kauman Kota Surakarta. Penelitian ini menggunakan metode yaitu deskriptif kualitatif. Teknik pengambilan sampel menggunakan teknik Stratified Sampling. Dalam penelitian ini teknik pengumpulan data menggunakan metode wawancara, kuisioner, dokumentasi. Dalam penelitian menggunakan Teknik analisis data yaitu analisis statistik deskriptif dan deskripsi spasial. Hasil penelitian ini menunjukan bahwa (1) Karakteristik sosio-demografi pemilik industri batik di Kampung Batik Kauman didominasi laki-laki, dengan didominasi oleh rentang usia 51-60 tahun, tingkat pendidikan sarjana, status pekerjaan industri batik merupakan sebuah pekerjaan utama (2) Karakteristik industri batik di Kampung Batik Kauman didominasi oleh industri rumah tangga, usia industri batik diatas 5 tahun yang paling banyak berada direntang usia 13- 20 tahun, jenis produk batik yang paling banyak dijual berupa daster batik atau home dress batik, kemeja batik dan blouse batik. (3) Wilayah pemasok batik berasal dari sekitar wilayah Kauman dan luar Kota Surakarta.

Kata Kunci : Karakteristik Pemilik Industri, Karakteristik Industri, Pola Interaksi Spasial
Studi aspek infrastruktur dalam penentuan pusat kecamatan pada perimeter kawasan Ibukota Negara Nusantara
Authors: Putra Rulliannor Syah , Jordan Nadia Almira
Published: February 2025

Peningkatan kebutuhan ruang bagi penduduk Kecamatan Penajam memberikan dampak terhadap perubahan fungsi guna lahan, dari yang semula kawasan pertanian, perkebunan, dan hutan rakyat, beralih fungsi menjadi kawasan non pertanian seperti fasilitas umum dan perumahan. Sebagai kecamatan dengan rata-rata laju pertumbuhan penduduk per tahun 2010–2020 sebesar 2,45%, pertumbuhan penduduk Kecamatan Penajam diperkirakan akan terus mengalami peningkatan dalam beberapa dekade yang akan datang. Salah satu indikasi yang mempengaruhi hal tersebut adalah lokasi Kecamatan Penajam yang berbatasan langsung dengan lokasi Pembangunan Ibu Kota Negara (IKN) Nusantara di Kecamatan Sepaku. Perubahan fungsi lahan dan jumlah penduduk tersebut dapat mempengaruhi bentuk struktur ruang Kawasan terbangun, khususnya penambahan percabangan jaringan jalan dan blok-blok bangunan. Penelitian ini bertujuan untuk mengetahui lokasi pusat Kecamatan Penajam sebagai titik pertumbuhan wilayah, yang berpotensi sebagai wilayah tujuan perpindahan penduduk di sekitar IKN. Analisis yang digunakan dalam penelitian adalah analisis indeks sentralitas, analisis kepadatan penduduk, kepadatan bangunan, kepadatan jaringan jalan, indeks beta dan indeks entropi. Seluruh hasil pemetaan dan pembobotan kemudian diolah menggunakan teknik overlay untuk mendapatkan hasil rangkuman analisis tentang pusat kecamatan sebagai pusat pelayanan. Hasil penelitian menunjukkan bahwa Pusat Kecamatan Penajam hanya memiliki satu sub pelayanan perkotaan dan empat sub pusat lainnya sebagai wilayah penyangga Pusat Kecamatan Penajam yaitu Kelurahan Penajam sebagai pusat pelayanan.
Analisis keberlanjutan pengembangan kawasan agropolitan (Studi kasus: Kecamatan Sepatan, Kabupaten Tangerang)
Authors: Septiawan Yeriko , Mardiah Andri N.R.
Published: February 2025

Masalah ketimpangan antara desa dan kota mengakibatkan timbulnya alih fungsi lahan pertanian menjadi lahan terbangun pada perkotaan, konsep kawasan agropolitan yang berkelanjutan dapat menjadi solusi masalah kesenjangan tersebut. Penelitian ini bertujuan untuk mengukur status keberlanjutan kawasan agropolitan yang berada pada Kecamatan Sepatan, Kabupaten Tangerang. Metode yang digunakan menggunakan analisis MDS (Multidimensional Scaling) dan analisis leverage, dengan menggunakan lima dimensi yaitu ekologi, ekonomi, sosial, infrastruktur serta hukum dan kelembagaan. Hasil penelitian menunjukkan bahwa Kawasan Agropolitan Sepatan, memiliki status kurang berkelanjutan (42,02%), dimana dimensi sosial, ekonomi, dan ekologi masih kurang berkelanjutan. Selain itu, terdapat 14 atribut sensitif yang harus diutamakan untuk meningkatkan status keberlanjutan. Maka, untuk mengatasi ketimpangan wilayah, peningkatan status keberlanjutan Kawasan Agropolitan Sepatan membutuhkan kebijakan yang terencana terutama pada dimensi ekonomi, sosial dan ekologi.  Atribut sensitif yang teridentifikasi pada penelitian ini juga dapat menjadi pertimbangan dalam pengembangan kawasan agropolitan di titik baru di Kabupaten Tangerang.
Analysis of potential tourism development in perintis reservoir by using environmental approach, Suwawa, Bone Bolango
Authors: Chow David , Maura Audrey , Suman Meliana Putri , Wicaksono Salsabilah Hamidah Putri , Pudianti Anna , Vitasurya Vincentia Reni
Published: February 2025

Perintis Reservoir has big potential with its amazing view, water coverage, and decent nature. However, the reservoir tends to be temporarily crowded by visitor when there is national event that held by government. Moreover, the majority of visitor is only local people. The objective of this study is to create a recommendation and guideline to enhance the future development of Perintis reservoir, so it can be regularly visited by local people, national tourist, and even international tourist. This study method employed various approaches, such as literature review, quantitative data collection, and observation. The identified problem in observation and data collection were solved by literature review. Research results show that there are some problems need to be solved such as inconvenient thermal conditions because of tropical climate and inadequate shading, unready urban facility, unorganized MSME, lack of walkability for pedestrians, and desolate tourism destinations. The environmental approach was chosen as the main solution because it’s the most suitable. The improvement of sidewalk, people domination rather than vehicle, and adding forest bathing sensation by planting wide-crown tree is needed. The Riparian buffer system and rain garden can help to balance water conservation while increasing the naturalness of the landscape. Cycling and other physical activities have a correlation with walkability and should be emphasized. Social physical activities and MSME’s integration with nutrition in wellness tourism themes can be a Perintis reservoir branding. 
International Community Development: Edukasi IMS dan HIV/AIDS pada Remaja Santri di Pondok Pesantren, Johor Bahru, Malaysia
Authors: Bilah Aisah Nur Ana , Nadzifah Yasmin , Yamani Laura Navika , Khairunisa Siti Qamariyah , Indriati Dwi Wahyu , Dinana Zayyin , Manas Nor Hasmaliana Abdul , Fuzi Siti Fatimah Zaharah Mohamad , Ya’akob Harisun , Aman Nor Farahiyah , Yusoff Nor Ida Madiha
Published: February 2025

Community development programs have the potential to enhance adolescents' awareness of the risks associated with sexually transmitted infections (STIs) and the preventive measures that can be taken to mitigate those risks, including HIV/AIDS. The International Community Development program was organized by the Research Centre on Global Emerging and Re-emerging Infectious Diseases (RC-GERID) of Universitas Airlangga. The topic of the program was the prevention of  STIs and HIV/AIDS among adolescent boarding school students. The objective of this activity is to enhance the student's knowledge and comprehension of STIs and HIV/AIDS, as well as the measures that can be taken to prevent the transmission of infectious diseases. The participants were 100 Madrasah Tahfidz Al-Quran An-Nur students in Johor Bahru, Malaysia. The methodology employed in this activity comprised pre-test and post-test questionnaires completed by participants, lectures, question-and-answer sessions, and discussions. The results demonstrated a statistically significant increase in knowledge and understanding of STIs, HIV/AIDS, and infection prevention among adolescent students, with an average increase of 22.0% in pre-test and post-test scores. This indicates that the educational material was effectively conveyed to the participants. The activity was conducted in an orderly, conducive, and interactive manner. Further community service with similar activities to be better than now
 
Abstrak
Remaja merupakan kelompok yang rentan terhadap IMS dengan jumlah terbesar mengidap HIV/AIDS. Program pengabdian masyarakat dapat membantu meningkatkan kesadaran remaja tentang risiko dan langkah pencegahan penyakit IMS dan HIV/AIDS. International Community Development ini diselenggarakan oleh Research Center on Global Emerging and Re-emerging Infectious Diseases (RC-GERID) Universitas Airlangga, dengan topik pencegahan IMS (Infeksi Menular Seksual) dan HIV/AIDS pada remaja santri pondok pesantren. Tujuan kegiatan ini untuk meningkatkan pengetahuan dan pemahaman siswa mengenai IMS dan HIV/AIDS serta langkah pencegahan penyakit infeksi. Peserta kegiatan yaitu remaja santri di Madrasah Tahfidz Al-Quran An-Nur, Johor Bahru, Malaysia yang berjumlah 100 orang. Metode dalam kegiatan ini yaitu pengisian pre-test dan post-test oleh peserta, ceramah, tanya jawab dan diskusi. Hasil menunjukan bahwa adanya peningkatan pengetahuan dan pemahaman tentang IMS, HIV/AIDS, dan pencegahan infeksi pada remaja santri, dengan kenaikan nilai pre-test dan post-test sebesar 22,0%. Hal ini berarti materi edukasi tersampaikan dengan baik kepada peserta. Kegiatan berlangsung dengan tertib, kondusif, dan interaktif. Pengabdian masyarakat selanjutnya dengan kegiatan serupa agar lebih baik dari sekarang.
A Hermeneutic Exploration of Subjectivity of the Translator—With Multiple Chinese Translations of Pride and Prejudice as Examples
Authors: Liang Yu , Ye Jiamei
Published: February 2025

The importance of translator’s subjectivity exists objectively, as a subject in translation activities, translator’s subjectivity cannot be underestimated. The translation theory, Hermeneutics and the representative figure of it, George Steiner and his translation theory “four steps of translation”, namely trust, aggression, incorporation and restitution, is the best interpretation of the translator’s subjectivity. Therefore, with the support of Hermeneutics and the theoretical guidance of Steiner’s “four steps” in translation, this study will analyze different Chinese versions of Pride and Prejudice, focuses on and examine the embodiment of the translator’s subjectivity in translation.
DISCOURSE OF HADITH’S HERMENEUTIC: Limitations and Terms of Application for Applying Five Hermeneutical Approach
Authors: Al Faruq Abdul Qudus , Al Azzam Hilmi Faiz , Ubet Abdulloh , Yardho Moh.
Published: February 2025

The model of hadith Hermeneutics has been applied by some contemporary scholars attracting attention to be studied scientifically, as there is already a method of understanding hadith called syarh hadits in the study of ‘Ulumul Hadits. So the purpose of this study is to discuss the limitation of the application of the hermeneutic approach to hadith as well as to examine the position of hermeneutics in the minds of Islamic academics. The research method is qualitative research, then references from books (library research). The results of the study concluded that hermeneutics of hadith can be used in understanding hadith, although it is still within the scope of ta’wil and is not the main reference in understanding the text of the Prophet’s hadith. Hermeneutics is seen as an explanatory tool for religious texts that can still be used with restrictions and conditions not to demonize religious values, but Islamic methods such as Syarhu Hadist in ‘Ulumul Hadist remain the main reference in interpreting hadith texts. The author recommends strengthening Islamic knowledge before using hadith hermeneutics, in order to guard against errors in understanding hadith such as Jarh wa Ta’dil, ‘Rijalu al-Hadith, Nasikh wa Mansukh Al-Hadith and ect.

[Model Hermeneutika Hadis telah diterapkan oleh beberapa ulama kontemporer menarik perhatian untuk diteliti secara ilmiah, sebagaimana sudah ada sebuah metode memahami hadis yang disebut dengan syarh hadits dalam kajian ‘Ulumul Hadits. Sehingga tujuan penelitian ini untuk membahas batasan penggunaan pendekatan hermeneutika terhadap hadis sekaligus meneliti kedudukan hermeneutika dimata akademisi islam. Metode penelitian ini adalah kualitatif yang termasuk pada kajian kepustakaan (library research). adapun Hasil penelitian menyimpulkan bahwa hermeneutika hadis dapat digunakan dalam memahami hadis, meskipun masih dalam cakupan ta’wil dan bukan rujukan utama dalam memahami teks hadis Nabi. Hermeneutika dilihat sebagai alat penjelasan terhadap teks keagamaan yang masih boleh digunakan dengan batasan dan syarat tidak untuk menjelek-jelekkan nilai keagamaan, adapun tetapi metode islam seperti syarh hadits dalam ‘Ulumul Hadits tetap menjadi acuan utama dalam interpretasi teks hadis. Penulis merekomendasikan untuk memperkuat keilmuan islam sebelum menggunakan hermeneutika hadis, agar dapat menjaga kesalahan dalam pemahaman hadis seperti Ilmu Jarh Wa Ta’dil, ‘Ilmu Rijalu Al-Hadits, Nasikh wa Mansukh Al-Hadits dan lain sebagainya.]
Protection of Women's Rights After Divorce in Religious Courts: What Makes this Mission Difficult to Achieve?
Authors: Yuni Lilik Andar , Haries Akhmad
Published: February 2025

The normative assurance of protection for women's and children's rights post-divorce has been extensively regulated through laws, including the Compilation of Islamic Law (KHI), the Supreme Court Regulation (PERMA), and the Supreme Court Circular Letter (SEMA). However, not all these regulations have been effectively implemented post-divorce in Indonesian Religious Courts. Hence, this article is written to understand how the implementation of post-divorce women's rights protection occurs in the Religious Courts, especially when the husbands are absent from the divorce trials (verstek judgments). This normative-doctrinal legal research utilizes the statutory and case law analysis of selected decisions from Samarinda and Sangatta Religious Courts. The findings indicate that the protection of post-divorce women's rights is not adequately realized, as not all the rights of former wives in the Religious Courts are adequately accommodated, especially the alimony (nafkah iddah). This is attributed to cases being decided in absentia of the husband, indications of the wife's disobedience (nushuz), low awareness of the wife regarding her rights, and the gender sensitivity of the judges not being maximum.
Strategy for Sustainable Halal Tourism Development in Perlang Village, Bangka Belitung Islands Province, Indonesia
Authors: Maftukhatusolikhah Maftukhatusolikhah , Handayani Disfa Lidian , Pratomo Nardi , Iqbal M. , Litriani Erdah
Published: February 2025

In developing halal tourism, enhancing competitiveness must also address other important issues, such as environmental sustainability. After Covid-19, environmental issues increased along with the growth of halal tourism. Consequently, it is essential to implement effective strategies for developing halal tourism. Perlang is one of the villages that has succeeded in turning former mining land into a tourist attraction, and is recognized as one of the 50 best tourist attractions in Indonesia. This research aims to see how specific strategies have been used in developing a tourist village with the concept of sustainable halal tourism. It also looks at how the strategy model is effectively utilized to realize a tourist village concept that carries halal and sustainable values. It employs a qualitative method with a case study of Perlang Village by exploring documentation, observation, interviews, and Focus Group Discussions. The results showed that the Sustainable and Responsible Halal Tourism development model in Perlang fulfills the indicators that make it attractive, authentic, and consistent with halal principles, aligned with achieving sustainable development goals. The benefits of this tourist destination can be felt by the wider community inclusively and future generations.
High-Resolution Fault Geometry and Motion of the August 23, 2011, Mw 5.8 Mineral, Virginia, Aftershock Sequence Revealed Using Double-Difference and Moment-Tensor Inversion Methods
Authors: Hilfiker Stephen G. , Ebel John
Published: February 2025

The August 23 , 2011 MW 5.8 Mineral, Virginia, earthquake, the largest magnitude event recorded in the Central Virginia Seismic Zone, caused widespread damage and generated a lengthy and well-recorded aftershock sequence. Over 1600 aftershocks, recorded using a dense network of seismometers in the 4 months following the mainshock, offer an important opportunity to study the fault structure responsible for the postmainshock seismicity and hence to infer details about the mainshock rupture. In this study, the relative locations of well-recorded aftershocks were calculated to generate a high-resolution model of the fault structures on which the aftershocks took place. Moment-tensor inversions of the P and S amplitudes of dozens of the aftershocks at various locations in the aftershock zone were used to generate focal mechanisms for events on the different fault structures that were imaged by the relative location analysis. These focal mechanisms reveal both normal and thrust faulting on the fault structures. Results from these two analyses map the structures responsible for the aftershock sequence with high spatial resolution. The fault structures responsible for the aftershocks consist of two primary planes, one smaller planar feature, and some off-fault seismicity near the intersection of the two primary planes. The fault planes imaged in this study all appear to be part of the Quail Fault Zone.
Large-scale ice shelf calving events follow prolonged amplifications in flexure
Authors: Bennetts Luke , Teder Nathan , Reid Phillip , Massom Robert , Pitt Jordan , Scambos Ted , Fraser Alexander
Published: February 2025

The retreat of Antarctic ice shelves due to calving and the subsequent reduction in buttressing of the Antarctic Ice Sheet are of major concern for future sea-level rise. Sudden, widespread calving of weakened ice shelves has been linked to fracture amplification forced by ocean swell following regional sea-ice losses. Increases in magnitude and duration of swell-induced ice-shelf flexure in the lead-up to the calving events have not been tracked previously. We present seven-year datasets of sea-ice-barrier lengths and shelf-front flexural stress that encompass large-scale calving events of the Wilkins and Voyeykov ice shelves. We find the ice shelves share traits of preconditioning by prolonged amplifications in flexure and collapse of adjoining fast-ice barriers. We propose a conceptual model for the swell–sea-ice–shelf-front conditions leading to the calving events and discuss its implications further large-scale calving events as sea ice retreats and ice shelves thin.
Investigating the Efficacy of Dexmedetomidine as an Adjuvant to Local Anesthesia in Dentistry: Systematic Review and Meta Analysis
Authors: Abdu Salah Ameen , Asaad Wafa Ali , Wei Tao , Wdaan Muaadh , Wan Wendong , Huang Yu-Qi , Li Ning
Published: February 2025

Background and Objectives: Dexmedetomidine has been considered an effective adjunct to dental local anesthetics. Uncertainty about its efficacy and safety in dental use still remains. This study is primarily designed to evaluate the effectiveness and safety of dexmedetomidine as an adjunct to local anesthesia in dental procedures.
Methods: A meta-analysis of controlled trials assessed the effects of dexmedetomidine as an adjunct to local anesthesia in dental procedures, focusing on anesthesia duration and onset time. Studies were identified via multiple databases, and methodological quality was evaluated using ROBINS-I and Cochrane Risk of Bias tools. RevMan V.5.1 was used for heterogeneity analysis, sensitivity analyses, pooling mean differences (MD) and risk ratios (RR) with 95% confidence intervals (CI), and assessing publication bias.
Results: This meta-analysis included sixteen clinically controlled trials involving 658 patients (n=877 samples). Adding dexmedetomidine significantly reduced onset time by 48.78 seconds (95% CI: -64.22 to -33.35 seconds) and prolonged analgesia duration by 31.10 minutes (95% CI: 13.77 to 48.43 minutes). It also significantly increased postoperative analgesic duration by 186.19 minutes (95% CI: 109.09 to 263.29 minutes). Hemodynamic analysis revealed non-significant changes in heart rate, intraoperative systolic and diastolic pressures, and oxygen saturation. It is important to note that minor heart rate and blood pressure fluctuations did not lead to clinically significant hypotension or bradycardia during dental procedures.
Conclusions:Dexmedetomidine enhances dental local anesthesia by providing quicker onset, longer duration, improved postoperative pain management, and a favorable safety profile, though further research is needed to address variability.
Early intrinsic plasticity of neocortical engram neurons defines memory formation and precision
Authors: Frick Andreas , Hadzibegovic Senka , Zhu Liangying , Ginger Melanie , De Sa Rafael , Corf Katy Le , Costa Maria Gueidao , Feuvre Yves Le , Nicole Olivier , Bontempi Bruno
Published: February 2025

Neocortical memory engrams are thought to stabilize and mature via enhanced interconnectivity during the so-called systems-consolidation process 1,2. While synaptic plasticity of these engram connections is considered an important mechanism for storing memories 3,4, it cannot fully account for the dynamic vividness of remote, cortically-based memories. Indeed, cell-intrinsic plasticity has been touted as the crucial early priming mechanism that renders nascent engram neurons susceptible to ongoing plastic processes while providing flexibility for later encoding events 5–7. Here, we reveal that learning-related neuron-wide intrinsic excitability (IE) plasticity of nascent cortical engram neurons is a permissive mechanism for the formation and specificity of remote associative memories. Using a c-fos-dependent genetic and viral system for the targeted labeling of engram neurons in the anterior cingulate cortex (ACC) combined with ex vivo electrophysiology, we found that contextual fear learning triggered a time-dependent increase in their IE signature expressed over days during the early, but not late, phase of memory formation. Remarkably, chemogenetically hyperpolarizing engram neurons during this early plastic phase enhanced their maturation, increasing the strength and context-precision of consolidated memories and preventing memory disturbance caused by an interference event. Altogether, our findings identify cell-intrinsic plasticity within nascent ACC engram neurons as an essential tagging mechanism whose features determine the fate and dynamic content of remote memories.
Repellent Efficacy of Azadirachta indica and Ocimum sanctum Extracts against Tenebrio molitor Larvae
Authors: Shaw Pintu Kumar , Hassan S. M. Mahboob
Published: February 2025

The yellow mealworm, Tenebrio molitor, is a significant pest of stored grains, causing substantial economic losses. The widespread use of chemical insecticides has raised concerns about environmental pollution, human health risks, and insect resistance. This study investigates the repellent potential of ethanolic extracts of Azadirachta indica (Neem) and Ocimum sanctum (Tulsi) against T. molitorlarvae. The results indicate that Neem extract exhibits higher repellency (84.28%, 85.89%, and 88.87% at 1%, 2%, and 3% concentrations, respectively) compared to Tulsi extract (66.02%, 69.97%, and 75.21% at 1%, 2%, and 3% concentrations, respectively). Notably, the combined extract of Neem and Tulsi demonstrates enhanced repellency (85.56%, 88.56%, and 90.63% at 1%, 2%, and 3% concentrations, respectively). This study highlights the potential of Neem and Tulsi extracts as eco-friendly grain protectants against T. molitorlarvae.
A New Pooling Method for Cnn-based Deep Learning Models
Authors: TURHAN KEMAL , Kalaycı Erşan , Özdemir Sinem
Published: February 2025

Convolutional Neural Network (CNN) methods provide an effective architecture widely used in image classification tasks. The pooling method in CNN layers has a critical role in reducing the computational cost by preserving some information in the feature map. The primary objective of this study is to improve information loss in pooling methods used in the literature and enhance classification accuracy. The Turhan pooling method offers a weighting, balancing, and adjustment capability beyond traditional max-pooling and average-pooling methods. This method allows tuning the parameters of the two features with the highest signal that can generate action potentials in the pooling mechanism similar to biological neurons. The method enables to optimize pooling for specific datasets or tasks. The results demonstrate that the Turhan pooling method is effective and competes with different architectures such as CNN, AlexNet, U-Net, and ResNet-18 on the Cifar10 dataset, improving classification performance.
The effect of organizational Justice on organizational citizenship behavior through the mediating role of Organizational commitment in the Public universities in Amhara region
Authors: Mesfin Shimelis
Published: February 2025

The purpose of this study was to examine the effect of organizational justice (OJ) on organizational citizenship behavior (OCB) through the mediating role of organizational commitment (OC) in the public universities in Amhara region. Explanatory mixed research design was employed. The size of the population was 2170. Of these, 620 instructors were selected as samples using a proportional stratified random sampling technique. Five interviewees took part in the qualitative part of the study. The collected data were analyzed using both quantitative and qualitative techniques. The result of one sample t-test indicated that the mean scores of OC (52.981) and OCB (71.363) were higher than the respective test values of these variables with (t = 15.398) and (t = 5.639) at p < .05, df = 619. On the contrary, the mean score of OJ (43.934) was lower than the test value with (t = -11.987, df = 619) at p < .05. The result of the structural equation modeling (SEM) indicated that there were positive and statistically significant relationships among OJ, OC, and OCB. Concerning the causal relationships, the value of R2 indicated that OJ significantly predicted 44.3% of the variance in OC with a standardized regression coefficient of (β = .667) at p < .05, while 29.2% of the variance in OCB was significantly predicted by the joint effects of OJ and OC with standardized regression coefficients of (β = .341) and (β = .164) respectively at p < .05. Statistically significant differences were found among instructors in their perception of OJ (F = 132.833, p = .000), OC (F = 3.163, p = .024) and OCB (F = 19.071, p = .000) across the four generations of universities. Therefore, it is concluded that OJ had a significant effect on OCB through the mediation of OC. Thus, it is suggested to improve the current status of OJ, OC, and OCB in the research sites.
Village Fund And Village Development In West Java Province
Authors: Ramdani Sandi Asep , Kharisma Bayu
Published: February 2025

Rural development programs that involve village communities as development subjects (Community Driven Development) have been implemented in various countries, including Indonesia through the village fund program. West Java, a province with a high accumulation of village funds, has a low Village Development Index (IDM) growth. This study analyses the contribution of village funds and Village Sustainability Development Goals (SDGs) to IDM in West Java. Using panel data regression with fixed effect and Difference in Difference (DiD), data from 5.312 villages receiving village funds in the 2018–2023 period were analyzed. The study found that overall, village fund realization had a positive and significant effect on IDM, with the funds predominantly used for infrastructure development in the Village Development Sector. The regression results per Sector also found that all Village Fund Sectors had a positive and significant influence on the IDM value, with the highest influence from activities in the Village Development Sector. DiD analysis revealed that aligning village fund activities with Village SDGs has not yet significantly impacted IDM growth. Therefore, to accelerate village development, the Government should prioritize using village funds not only for infrastructure but also for activities like Village Community Empowerment while promoting the alignment of these funds with Village SDGs.
Beyond Voice Recognition: Integrating Alexa’s Emotional Intelligence and ChatGPT’s Language Processing for EFL Learners’ Development and Anxiety Reduction - A Comparative Analysis
Authors: Tajik Aliakbar
Published: February 2025

This groundbreaking study investigates the integration of Amazon Alexa, an emotionally intelligent AI platform, into English language teaching through an adaptive language learning system. Using a mixed-methods design, the study examined the impact of this innovative platform on the speaking skills of 40 high school students (aged 16–18) from Varamin County, Iran. The experimental group (n = 20) engaged with Amazon Alexa's emotionally intelligent platform, which provides AI-driven real-time feedback based on emotional intelligence (EI); in contrast, the control group (n = 20) received instruction using ChatGPT-3.5 over eight sessions following a pre-test to ensure group homogeneity. The study employed a concurrent mixed methods design, with quantitative data collected using the researcher-developed Speaking Assessment System and the researcher-developed Perception Questionnaire; qualitative data were derived from researcher-developed classroom observation checklists and researcher-developed semi-structured interviews (n = 15), focusing on emotional state monitoring and anxiety reduction patterns. Statistical analyses revealed a significant positive correlation between Alexa's EI-based instruction and speaking performance (p < 0.05, η2 = 0.42), with the experimental group showing significantly improved performance (F(1,38) = 24.63, p < 0.05). Amazon Alexa's emotional state detection capabilities demonstrated 94% accuracy in identifying and responding to learners' emotional states. This study represents a paradigm shift in language learning technology, leveraging Amazon Alexa's emotionally intelligent platform to address cognitive and emotional aspects of language acquisition simultaneously. The findings have significant implications for the global language learning market, particularly in addressing speaking anxiety and emotional barriers to language learning. The platform's scalability and cross-cultural applicability make it a potentially transformative solution for language learning worldwide, opening up new avenues for the development of emotionally intelligent educational technology.
Self-consistent models of Earth's mantle and core from long-period seismic and tidal constraints
Authors: Munch Federico Daniel , Kemper Johannes , Khan Amir , Helffrich George , Giardini Domenico
Published: February 2025

Here we illustrate the use of self-consistent models to address fundamental questions about Earth's mantle and core structure. For this purpose, we invert a large set of recent normal-mode centre frequencies and quality (attenuation) factors, along with astronomic-geodetic data (mass, moment of inertia and tidal response), for the radial anelastic seismic structure of the Earth. We consider two distinct parameterisations that rely on 1) self-consistent and 2) physically-parameterised models. In the self-consistent approach, mantle models are constructed using petrologic phase equilibria in combination with a laboratory-based viscoelastic model connecting dissipation from seismic to tidal periods (~100~s--20~yr), whereas seismic properties for a homogeneous and adiabatic core are computed using equations-of-state. The physically-parameterised models follow the preliminary reference Earth model (PREM) and rely on a polynomial representation of density, P- and S-wave velocity, attenuation, and anisotropy. To study the impact of the inferred mantle seismic velocity structure, we compute P- and S-wave travel times and compared these to the observations of globally-averaged body wave travel times from the reprocessed ISC catalog. To further refine the seismic P-wave velocity structure of the outermost outer core, we also consider multiple core-mantle-boundary underside-reflected body wave travel times. The results indicate deviations from PREM, including a denser outer core, which possibly reduces the requirement for light elements, while diminishing the density contrast across the inner-core boundary. Finally, and of general interest to the wider community, uncertainty measures on all inverted properties are provided with the models presented here.
COMPARATIVE STUDY OF PHACO-TRABECULECTOMY AND SMALL INCISION CATARACT SURGERY TRABECULECTOMY IN 50 CATARACT PATIENTS
Authors:   Associate Professor, Department of Ophthalmology, DVVPFs Medical College & Hospital, Ahmednagar, Maharashtra, India., Kapase Anjali , Pawar Rahul ,   Junior Resident, Department of Ophthalmology, DVVPFs Medical College & Hospital, Ahmednagar, Maharashtra, India.
Published: February 2025

Objective: To compare the clinical outcomes and complications of phaco-trabeculectomy and small incision cataract surgery (SICS) trabeculectomy in patients with cataracts.

Methods: A prospective study was conducted involving 50 cataract patients divided into two groups: 25 patients underwent phaco-trabeculectomy and 25 underwent SICS trabeculectomy. Preoperative and postoperative parameters such as intraocular pressure (IOP), visual acuity (VA), surgical time, and complication rates were analyzed.

Results: The study showed that both phaco-trabeculectomy and SICS trabeculectomy effectively reduced intraocular pressure and improved visual acuity. However, phaco-trabeculectomy had a significantly shorter surgical time and fewer postoperative complications compared to SICS trabeculectomy.

Conclusion:Phaco-trabeculectomy offers better safety and efficacy compared to SICS trabeculectomy, making it a preferable choice for managing cataract patients requiring trabeculectomy.
UTILITY OF HEMATOLOGICAL SCORING SYSTEM IN DIAGNOSIS OF NEONATAL SEPTICEMIA
Authors: Khadija Irum Khadija Irum , Mateen Ahmed Mohammed , Bhosle Smita , J. Ingin Rajashree
Published: February 2025

Objectives: To evaluate the utility of the hematological parameters and HSS score for early detection of neonatal septicemia and to correlate results with blood culture reports and C-reactive protein (CRP) levels.

Material and Methods: Blood samples of 60 neonates with the clinical diagnosis of neonatal septicemia were collected. Peripheral smears of these neonates were evaluated and scored as hematological parameters of Rodwells criteria (score of < 2 â€“ unlikely septicemia, 3 or 4- possible septicemia and > 5 very likely septicemia).A comparison of the HSS score, CRP value and blood culture report was done.

Statistical analysis: Data was entered in a Microsoft Excel spread sheet & analyzed using SPSS Software Version 16.

Result: Out of 60 caseswith the clinical diagnosis of neonatal septicemiastudied, HSS score of 15cases (25%) score 4, 28 cases (46.6%) scored 5 and 17(28.3%) cases had a score of 6. Sensitivity of the Immature Neutrophil Count andDegenerative changes was 100%. In 30 cases (50 % cases) blood culture report was positive. In neonates with positive blood culture reports had > 5 HSS score in 86 % of the cases and raised CRP in 80 % of the cases. In neonates with negative blood culture reports had > 5 HSS score in 63 % of cases and raised CRP in 80 % of cases.

Conclusion: HSS is a rapid, simple and reliable test that helps in early diagnosis and treatment of neonatal septicemia.
MOLECULAR DOCKING STUDIES OF FLAVONOIDS AGAINST DRIVER MARKERS IN LOW-GRADE GLIOMA: EXPLORING NOVEL THERAPEUTIC APPROACHES
Authors: Sreeramulu E. , Kranthi Kumar K. , Rishika P. , Umadevi B. , Suneetha Y.
Published: February 2025

Low-grade gliomas (LGGs) are a group of slow-growing brain tumors that often exhibit long-term survival in patients. However, the lack of effective therapeutic strategies and the eventual progression to high-grade gliomas pose significant clinical challenges. Driver markers, such as IDH1, TP53, and ATRX mutations, play pivotal roles in the molecular pathogenesis of LGGs. Flavonoids, a group of polyphenolic compounds found in fruits and vegetables, have been recognized for their potential anticancer properties. In this study, we employed molecular docking to evaluate the binding affinities of flavonoids against IDH1, a key driver marker in LGG. Our results demonstrate that certain flavonoids exhibit strong binding interactions with the active site of IDH1, suggesting their potential as novel therapeutic agents for LGG. This study provides insights into the development of flavonoid-based therapies targeting driver markers in LGG.
VAPB Promotes Osteogenic Differentiation in Aortic Valve Interstitial Cells via Activation of the SMAD Signaling Pathway
Authors: Liu Xiaolin , Xing Kai , Zheng Qiang , Li Ting , Ma Xiaochun , Zhang Tao , Sun Jun , Song Jian , Wang Zhengjun
Published: February 2025

Objective:

Prior studies have associated vesicle-associated membrane protein-
associated protein B (VAPB) with various cardiovascular diseases, yet its role in calcific
Aortic Valve Disease (CAVD) is not fully understood. This study aims to elucidate
the relationship between VAPB and aortic valve calcification at both tissue and cellular
molecular levels, exploring potential regulatory mechanisms.

Methods:

The expression levels of VAPB in calcified valve tissues were assessed using
immunohistochemical analysis. Osteogenic differentiation and calcification levels of
valve interstitial cells (VICs) were evaluated by alizarin red staining, calcium content
quantification, and the detection of the osteogenic markers. Gene set enrichment analysis
(GSEA) was used to identify downstream pathways regulated by VAPB, immunoblotting
was used to detect the expression of key molecules of SMAD signaling,
and immunoprecipitation was performed to detect interactions between VAPB and
SMAD1/5/9.

Results:

VAPB expression was significantly upregulated in the aortic valve leaflets of
patients with CAVD. VICs with VAPB overexpression exhibited a significant increase
in calcium content (p < 0.001) and upregulation of osteogenic markers RUNX2, osteocalcin,
and osteopontin (p < 0. 01). Conversely, VAPB knockdown reduced osteogenic
differentiation in VICs. Furthermore, VAPB overexpression led to the enhanced expression
of p-SMAD1/5/9 through activation of the SMAD signaling pathway (p < 0.05),
while inhibition of the SMAD pathway abrogated the pro-calcification effects of VAPB.
Dual immunofluorescence staining demonstrated colocalization of VAPB with
SMAD1/5/9, and immunoprecipitation confirmed an interaction between VAPB and
SMAD1/5/9.

Conclusion:

The findings indicate that VAPB promotes osteogenic differentiation in aortic
valve interstitial cells by activating the SMAD signaling pathway.

result:

VAPB expression was significantly upregulated in the aortic valve leaflets of patients with CAVD compared to normal aortic valves. VICs with VAPB overexpression exhibited a significant increase in calcium content (p < 0.001) and upregulation of the transcription factor RUNX2 and the osteogenic markers osteocalcin and osteopontin at both mRNA and protein levels (p <0. 01). Conversely, VAPB knockdown reduced osteogenic differentiation in VICs. Furthermore, VAPB overexpression led to the enhanced expression of p-SMAD1/5/9 through activation of the SMAD signaling pathway (p < 0.05), while inhibition of the SMAD pathway abrogated the pro-calcification effects of VAPB. Dual immunofluorescence staining demonstrated colocalization of VAPB with SMAD1/5/9, and immunoprecipitation confirmed an interaction between VAPB and SMAD1/5/9.
The Role of Jianpi Jiedu Recipe in Modulating the CRC Microenvironment
Authors: Li Mengyao , Hua Dongming , Feng Yuanyuan , Wang Zhiyan , Hu Xueqing , Wang Yan
Published: February 2025

Background:

The anti-tumor effects of Traditional Chinese Medicine has been recognized
in regulating the tumor microenvironment. Jianpi Jiedu Recipe (JPJDR) is clinically effective in enhancing
the chemotherapy efficacy in Colorectal Cancer (CRC) treatment and significantly improved
the quality of life of CRC patients. However, its therapeutic mechanism remains to be investigated

Material and Methods:

The active compounds of each herb in JPJDR were obtained from the HIT2.0
and HERB databases supported by evidence in literature. Single-cell RNA sequencing data of CRC
were obtained from published studies (PMID: 32451460, 32103181, and 32561858). Pathway enrichment
was analyzed using the reactome database, and gene correlation analysis was performed using
the corrplot R software package. Gene expression regulated by JPJDR was verified by RT-qPCR.

Results:

Ye Pu Tao Teng, Ba Yue Zha, Huang Qi, Bai Zhu, Yi Yi Ren and Dang Shen contained 4,7,
18, 26,3 and 30 compounds, respectively, and they target to 38, 7, 262, 309, 50, 54 genes, respectively.
JPJDR is involved in a range of immune-related biological processes, including cytokine signaling,
cell proliferation, apoptosis and cellular senescence. JPJDR regulates various cell types in the CRC
microenvironment, including malignant CRC cells, immune cells (including CD4+ T cell, CD8+ T
cell, B cell, plasma cell, mast cell, and myeloid cell), and stromal cells (including fibroblast, pericyte,
enteric glial cell, and endothelial cell). We confirmed that JPJDR significantly downregulated the expression
of HMGB1 and MT2A in CRC.

Conclusions:

JPJDR regulates a range of cell types in the CRC microenvironment, including malignant
CRC, immune cells and stromal cells. Downregulation of HMGB1 and MT2A might be the important
mediators for JPJDR to modulate the CRC microenvironment.
Discovering Active Chemotherapeutic Agents for Sexually Transmitted Diseases to Inhibit Pathogenic HPV-16-E6 Protein
Authors: Vani Vemula , Alagumuthu Manikandan , Prasad Sanjay , Paul Nikita , Gajendra Nithya , Narayanaswamy Pooja , Venkataraman Pooja
Published: February 2025

Background:

One of the most prevalent sexually transmitted diseases (STDs) is infection
with the human papillomavirus (HPV). The current treatment methods comprise employing chemotherapeutic
medications or doing surgery to remove the developed tumors. A more affordable option
for treating HPV-related diseases has emerged with the advent of medication-based therapy. The
interaction between E6 protein and E6AP generates a p53 degradation complex in HPV-infected cells,
which facilitates carcinogenesis.

Objective:

The purpose of this work is to use a virtual screening technique to find possible small
molecule inhibitors against the HPV16 E6 protein.

Methods:

Compounds 5, 7, and 10 are three new HPV 16 E6 inhibitors that were created utilizing a
fragment-based methodology. The trials subset in the ZINC database was screened virtually using
the structural information of these three novel chemicals, yielding 9800 hits. Using the GLIDE module
of the Schrodinger software, three virtual screening phases were applied to the molecules that
were collected from the database. MD simulations and DFT (Density Function Theory) were also
carried out.

Results:

The findings indicated that when compared to the reference molecule, luteolin, the five-hit
compounds (ZINC000034853956, ZINC000001534965, ZINC000095617673, ZINC000005764481,
and ZINC000071606215) demonstrated superior glide scores. Important interactions between these
compounds and the HPV 16 E6 protein were seen. Using the QikProp tool, the pharmacokinetic characteristics
of these hit compounds were examined. The findings demonstrated that the pharmacokinetic
characteristics and oral absorption by humans of all five compounds were found to be satisfactory.
Except for ZINC000005764481, all five hit compounds were predicted to be toxic; the remaining
four displayed drug-like characteristics.

Conclusion:

To create HPV 16 E6 inhibitors for the treatment of HPV-related disorders, the four hit
compounds (ZINC000034853956, ZINC000001534965, ZINC000095617673, and ZINC00007160-
6215) can be employed as lead molecules.