bluuebunny/crossref_metadata_2025 huggingface dataset:
Design of a Marketing Plan for Products from the Inagro de Latacunga Agricultural Innovations Center
Authors: Eleonora Intriago Perdomo Dayana , Samuel Pomaquero Pinda Nestor
Published: October 2022

The objective of this research is to design a marketing plan for the development and growth of the INAGRO Agricultural Innovations Center of the Latacunga canton. The plan has been developed based on the theoretical foundations of theses related to the design and structuring of marketing plan models and information obtained from the field surveys of the selected population. Using a deductive and descriptive research method through qualitative and quantitative techniques allowed us to reach the right conclusion. In addition, for the collection of information from primary sources, the entire client population was used as the sample for the study. In this way, based on the information obtained, it was established that the organization is the object of analysis, which allows for promoting the design of strategies and thereby helps reach the proposed goal. Finally, through the evaluation matrices used, it was possible to denote in detail the factors that influence the final sales directly and indirectly.
Keywords: strategic planning, economic system, agronomy, agricultural development, interest group, technological innovation.
Resumen
El presente trabajo de investigación tiene como objetivo diseñar un plan de marketing para el Centro de Innovaciones Agropecuarias INAGRO del cantón Latacunga, mismo que impulse el desarrollo y crecimiento de la organización que ha sido objeto de estudio cuyo desarrollo principalmente se ha fundamentado en sustentos teóricos de tesis relacionadas con el diseño y estructuración de modelos de plan de marketing e información obtenida de campo mediante el empleo de encuestas a una población considerablemente reducida. En este sentido, se consideró la utilización de metodología que comprendió los métodos de investigación de tipo deductivo y descriptivo, a través de técnicas cualitativas y cuantitativas que nos permitieron llegar a conclusiones correctas acerca de la situación de la organización. Además, para la recopilación de información de fuentes primarias se determinó la utilización de toda la población de clientes como objeto de estudio y a su vez al miembro que ocupa la gerencia general. De esta manera, en base a la información obtenida, se estableció que la organización es objeto de análisis el cual permitirá impulsar el diseño de estrategias que permitan alcanzar la meta propuesta. Finalmente, mediante las matrices de evaluación empleadas se permitió denotar a detalle los factores que influyen directa e indirectamente como muestra del análisis sobre la intervención de variables que establecen las fortalezas, debilidades, oportunidades y amenazas de la organización.
Palabras Clave: planificación estratégica, sistema económico, agronomía, desarrollo agrícola, grupo de interés, innovación tecnológica.
Creation of an Agrotourism Operator to Strengthen the Tourism Sector in the Canton of San Pedro Pelileo
Authors: Caizabanda José Mariano Masaquiza , Marcelo Masaquiza Jerez Christian , Israel Vaca Anchatuña Darwin
Published: October 2022

The present research was carried out in the San Pedro de Pelileo community, Tungurahua Province in Ecuador, with the objective of creating an agrotourism operator in Pelileo to promote tourism in the canton and for the socioeconomic development of the parish, taking into account mainly the strengths and weaknesses of the territory. A nonexperimental crosssectional research based on reviews of related scientific articles and official pages was conducted. Additional information was collected through a survey of 361 inhabitants. The results of this study were able to verify that associative and collaborative work should be included to strengthen the economy of the Pelileo canton and make it one of the most important tourist destinations in the province of Tungurahua, Ecuador.
Keywords: agriculture, tourism, agrotourism, sustainable development, social development, economic development.
Resumen
La presente investigación se realizó en el cantón San Pedro Pelileo Provincia de Tungurahua en Ecuador, teniendo como objetivo Creación de una operadora de agroturismo en Pelileo para promocionar lugares turísticos del cantón, para el desarrollo socioeconómico del sector, tomando en cuenta principalmente las fortalezas y debilidades del territorio para esta actividad clave para el desarrollo socioeconómico; para lo cual se aplicó una investigación no experimental de tipo transversal que tiene como propósito analizar un tema poco tratado basada principalmente en revisiones de artículos científicos y páginas oficiales con enfoque similar, además se recopiló información a través de la encuesta, la cual se aplicó a 362 habitantes de tamaño muestral que arrojó la formula estadística para poblaciones finitas. Los resultados fueron procesados mediante el programa Google Drive, obteniendo resultados favorables cuyo insumo aportador a proponer una ruta agroturística que aprovechará cada espacio en la localidad para promover el crecimiento socioeconómico lográndose convertir en un acertado candidato agroturístico en la provincia por su diversidad cultural y agrícola, beneficiando a sus habitantes y proyectar una nueva actividad económica. La presente investigación pudo constatar que se debe incluir el trabajo asociativo y colaborativo como un medio para el fortalecimiento del cantón Pelileo para convertirlo en uno de los más importantes destinos turísticos en la provincia de Tungurahua, Ecuador.
Palabras Clave: agricultura, turismo, agroturismo, desarrollo sostenible, desarrollo social, desarrollo económico.
Economic and Financial Situation of Furniture Removal Services (H4923.04) and Bridge and Viaduct Construction (F4210.32) Enterprises
Authors: Slusarczyk M. , Vallejo D. , Atiencia E.
Published: October 2022

The primary objective of this investigative work was to determine among the ISICs analyzed – the furniture removal services (H4923.04) and construction of bridges and viaducts (F4210.32), both of which maintain good operation and management – the ISIC that has better economic operation than the other. Bibliographic materials and calculations were studied, and a quantitative approach based on a deductive scheme was applied. Data were analyzed using the Microsoft Excel sheet. It was found that Ciiu 1: H4923.04 – FURNITURE MOVING SERVICES – has had a better economic standing in its operation compared to Ciiu 2 F4210.32 – CONSTRUCTION OF BRIDGES AND VIADUCTS – that presents values at 0 in its financial ratios, that is to say, its financial performance is not positive. The means obtained from each financial ratio were analyzed together with the coefficient of variation which showed that the data tend to be more dispersed in Ciiu 1: H4923.04 – FURNITURE MOVING SERVICES – since Ciiu 2 did not present data. Therefore, to conclude, it was possible to obtain the means of each of the ISICs in question in order to obtain a comparison between the two and to know the benefits they have obtained in the years 2018 and 2019.
Keywords: ciiu, financial analysis, means, variation coefficient.
Resumen
El presente trabajo investigativo tuvo como objetivo principal determinar entre los CIIU analizados servicios de mudanzas de muebles (H4923.04) y construcción de puentes y viaductos (F4210.32) cual ha tenido una buena situación económica en su ejercicio con el fin de determinar que CIIU ha tenido mejores operaciones en su ejercicio, se utilizó para el desarrollo del trabajo materiales bibliográficos y materiales de calculo que nos sirvieron para realizar el estudio respectivo, el método de enfoque aplicado a esta investigación es cuantitativo, el método se basa en un esquema deductivo y lógico, después de haber tenido el marco metodológico se pasó al análisis de resultados realizados en Excel y obtuvimos que el Ciiu 1 :H4923.04 - SERVICIOS DE MUDANZAS DE MUEBLES ha tenido una mejor situación económica en su ejercicio en comparación al Ciiu 2 F4210.32 - CONSTRUCCIÓN DE PUENTES Y VIADUCTOS que presenta valores en 0 en sus ratios financieros es decir que su desenvolvimiento financiero no es positivo, en la discusión se analizaron las medias obtenidas de cada ratio financiero junto con el coeficiente de variación y nos mostró que los datos tienden a ser más dispersos en el Ciiu 1: H4923.04 - SERVICIOS DE MUDANZAS DE MUEBLES ya que en el ciiu 2 no presentan datos, como conclusión obtuvimos que se pudo llegar a conseguir las medias de cada uno de los CIIU en cuestión para así poder obtener una comparación entre ambos y conocer cuáles son los beneficios que han obtenido en los años 2018 y 2019.
Palabras Clave: ciiu, análisis financiero, medias, coeficiente de variación
The Diagnostic Accuracy of Galectin-9 for Diagnosis of Endometriosis in Comparison with Laparoscopy
Authors: Jarollahi Sahar , Chaichian Shahla , Jarollahi Ali , Hajmohammadi Roya , Mashayekhi Reza , Shahmohammadi Fereshteh , Eslamivaghar Mohammad , Ghasemi Ziba
Published: October 2022

Background: Endometriosis is a common devastating gynecological disease with severe complications. Researches on noninvasive diagnostic tests with acceptable accuracy are still ongoing. The purpose of the present study was to evaluate the diagnostic value of serum Galectin-9 (Gal-9) level in comparison with laparoscopic results in endometriosis patients.
Methods: Sixty-one patients, referred to Booali, Rasool-e-Akram, and Pars Hospitals affiliated to Islamic Azad University of Medical Sciences, were recruited. Patients laparoscopically diagnosed with endometriosis were assigned to the case (n=32) and who diagnosed with other diseases were assigned to the control group (n=29). In general, 56 patients (30 in case and 26 in control group) completed the study. The serum level of Galectin-9 was measured using ELISA method before laparoscopy and was compared between the groups. Next, categorical variables were compared using Chi square and quantitative variables using independent samples t- test or Mann-Whitney U test. The Gal-9 cut-off was calculated using the Youden’s index and ROC curve; then, sensitivity, specificity, positive and negative predictive value, and positive and negative likelihood ratio of Gal-9 were reported. The p<0.05 were considered statistically significant.
Results: Mean serum level of Galectin-9 was 669.3±416.50 pg/ml in the case group and 265.42±492.30 pg/ml in the control group (p=0.001). Considering a cut-off value of 138 pg/ml, Galectin-9 had a sensitivity of 100% and specificity of 88.46% for diagnosis of endometriosis (p<0.001).
Conclusion: Galectin-9 measurement is helpful in diagnosis of endometriosis. Future studies are recommended for investigating the generalizability of these results.
Effects of Mindfulness-Based Stress Reduction on Blood Pressure, Mental Health, and Quality of Life in Hypertensive Adult Women: A Randomized Clinical Trial Study
Authors: Babak Anahita , Motamedi Narges , Mousavi Seyedeh Zeinab , Darestani Nadia Ghasemi
Published: October 2022

Background: Hypertension is one of the most important causes of cardiovascular diseases. Patients with hypertension have a lower quality of life. We aimed to evaluate the effects of mindfulness meditation on blood pressure, mental health, and quality of life in patients with hypertension.
Methods: This randomized clinical trial was performed in 2019 in Isfahan. Eighty adult women with Stage I or II hypertension were included and assigned randomly to 2 groups: 12 weeks of mindfulness-based stress reduction (MBSR) and routine care. At baseline and 1 week after the end of the intervention, blood pressure, stress, depression, anxiety, and quality of life of the studied participants were measured using the Depression, Anxiety, and Stress Scale-21 (DASS-21) and 36-Item Short Form Survey (SF-36) questionnaires. The data were analyzed using the independent t-test, the paired t-test, and the MANCOVA test.
Results: After the intervention, the mean systolic and diastolic blood pressures decreased significantly in the intervention group compared with the baseline (142.82±11.01 mmHg vs 133.7±510.43 mmHg for systolic pressure and 86.12±8.24 mmHg vs 79.15±6.26 mmHg for diastolic pressure) and the control group (140.18±14.27 mmHg vs 142.15±10.23 mmHg for systolic pressure and 84.62± 9.22 vs mmHg 88.51±8.54 mmHg for diastolic pressure; P=0.001). There was also a significant increase in quality of life, stress, anxiety, and depression scores in the intervention group (P<0.05).
Conclusion: The 12-week MBSR program resulted in a significant reduction in the mean systolic and diastolic blood pressures and improvement in mental health and different aspects of quality of life.
A Patient with Repeated Carotid Stent Thrombosis
Authors: Amin Arash , Maleki Majid , Norouzi Zeinab , Almasian Mohammad , Kohnaki Mina Ghorbanpoor
Published: October 2022

This article has no abstract.
Education for Citizenship – A Step Towards Democracy
Authors: Cureluşă Luiza Florentina
Published: October 2022

This article encompasses an interdisciplinary approach regarding the concept of education for citizenship which has multiple implications in the contemporary world. Thus, the paper tries to highlight the close connection which establishes between the citizen and the state, due to the citizenship status one acquires and to emphasize how important it is to educate the individual in terms of assuming this status. The main purpose of this type of new education is to approach citizenship and its advantages with a great sense of awareness, permanently trying to promote the contouring of an identity oriented towards democracy and a set of principles centered on respect for fundamental rights and freedoms and the rule of law. Concomitantly, the paper aims to define education, the „new educations” and to also underline the legal approach regarding education for citizenship as it was foreseen recently in the European recommendations as well as the way in which the Romanian legal provisions were harmonized accordingly.
Redwood and ebony blanks impulse convective drying
Authors:   BMSTU (Mytishchi branch), Moiseev S.A. , Deyanov D.I. ,   BMSTU (Mytishchi branch), Kosarin A.A. ,   OOO «Forcklad», Kuryshov G.N.
Published: October 2022

A review of literature sources on the physical and mechanical properties of redwood and ebony is given. A description of the characteristic properties of redwood and ebony wood is given. The place of growth of these species, varieties of properties depending on the area of their distribution are indicated. A review of literature sources on regime parameters for drying redwood and ebony wood blanks is given. The drying modes are given, which depend on the current moisture content of the wood and differ from each other in the initial and final temperatures, as well as the degree of saturation of the drying agent at the initial and final stages of drying. The principles of the structure of pulse modes of wood drying are considered. The modes of pulsed drying of redwood 50 mm thick and ebony 25 mm thick blanks are presented. The initial moisture content of mahogany and ebony blanks was determined according to GOST 16588. The control over the current moisture content was carried out by the method of control samples. And the development of drying stresses is based on power samples. The stresses arising during the drying of the workpieces were evaluated by the relative deformation of the power sections teeth, sawn from the control power samples. The use of pulsed modes allows you to reduce energy consumption and improve the drying quality.
State of plant species rating assessments approaches in fuzzy conditions of their monitoring
Authors:   BMSTU (Mytishchi branch), Poleshchuk O.M.
Published: October 2022

The paper analyzes the models of rating assessment of green spaces in large cities, developed by the author. Both models are based on the formalization of the state of plant species using linguistic variables that model the evaluation actions of experts in fuzzy conditions. The first model, developed earlier by the author, allows you to find the ratings of green spaces by comparing their states with each other. Thus, the resulting rating of the state of a plant species provides information about the advantages of one species over another, but does not provide complete information about the real state of green spaces. At the same time, it is possible that all plant species from the considered population, regardless of the rating, are not resistant to harmful urban environment. The second model, developed in this article, allows you to find the ratings of plant species based on their ideal state. For this, the distance between the linguistic variables that formalize the real state of a plant species and its ideal state is determined. Since the states of green spaces are compared with the ideal state, and not among themselves, the resulting rating of one plant species does not depend on the data obtained in the evaluation of other species. The developed models allow their alternative application depending on the goals and objectives.
Certification and identification of possible threats to information security of software and firmware
Authors:   BMSTU (Mytishchi branch), Komarov E.G. , Lozovetsky V.V. ,   BMSTU (Mytishchi branch), Lebedev V.V. ,   Russian Technological University — MIREA, Archipenko A.V. ,   Sochi International Innovative University
Published: October 2022

A number of methods, methods and tools are proposed for certification of software and firmware in information systems in order to select approaches and tools for working in non-standard situations in a constantly changing regulatory and methodological framework and possible threats to their information security. The type of certification under consideration is limited to methods and techniques for analyzing vulnerabilities and undeclared capabilities. This type of certification is intended for software research. Not all possible aspects related to this type of certification have been considered, however, the novelty and advantages of the approaches are based on some original approaches in cases where it is not clear how to present sets of input data for testing. Approaches to certification tests are presented using tools of our own design, which allows you to identify the main parameters necessary for assembling software and its research, and to parse software written in various programming languages. Based on the program of testing and verification of the object of assessment in accordance with the requirements of information security under a certain level of control, methods for conducting certification studies are proposed, the advantages of approaches using the available and proposed tools are shown. To save on the purchase of tools, some well-known, free and freely distributed tools, as well as effective and inexpensive software products, are proposed for use in tests.
Z obserwacji demonstracji
Authors: Fleischer Michael
Published: October 2022

Demonstracje odbywające się obecnie w Europie powodują konieczność sformułowania kilku nowych zadań badawczych, którymi prędzej czy później będziemy się musieli zająć w nauce o komunikacji. Z jednej strony nurtuje bowiem wielowymiarowość tych demonstracji, z drugiej fakt, że są one tylko widocznym skutkiem szerszego zjawiska. A ponieważ dzieje się tak w całej Europie, sprawa warta jest analizy. Konkretnie zaś chodzi o coś, co nazwać chcę — heterogenną homogennością (lub odwrotnie) dzisiejszych ruchów protestu na tle homogenizacji komunikacji w mediach aspołecznych. Ale wcześniej kilka uwag terminologicznych.
Wpływ treści politycznych na reakcje odbiorców kanału YouTube „Tygodnika NIE”
Authors: Sitek Bartosz
Published: October 2022

Korzystanie z serwisów oferujących dostęp do treści wideo stało się jedną z powszechnych form odbioru treści umieszczanych w sieci. Niniejszy tekst podejmuje wątek posługiwania się jawnymi oraz niejawnymi odwołaniami do polityki w treściach umieszczanych na profilu YouTube „Tygodnika NIE”. Odwołania te, jak pokazują przeprowadzone badania, różnicują reakcje odbiorców na prezentowane treści. Podstawą analizy były przeprowadzone badania własne. Projekt badawczy opierał się na podejściu ilościowym, z zastosowaniem do obliczeń metod statystycznych oraz wnioskowania statystycznego.
Wybuch pandemii koronawirusa a potencjalna trauma kulturowa. Refleksja nad autorami fanficiton jako nosicielami traumy
Authors: Krakowiak Martyna
Published: October 2022

Zmiany spowodowane wybuchem pandemii COVID-19 są dziś w środowisku naukowym rozpatrywane jako potencjalnie traumatogenne. Istnieje prawdopodobieństwo, że koronawirus zapisze się w tkance pamięci zbiorowej jako trauma kulturowa. By jednak do tego doszło, nosiciele traumy, na przykład artyści, publicyści czy osoby obecne w mediach muszą poprzez swoje narracje nadać zdarzeniom związanym z pandemią znaczenie oraz w odpowiedni sposób je utrwalić. Zamysłem przyświecającym artykułowi jest sprawdzenie, w jaki sposób autorzy i autorki fanfiction opisują covidowe zdarzenia oraz czy są przesłanki, by postrzegać ich jako nosicieli związanej z nimi traumy kulturowej. Zbadano w tym celu metodami analizy zawartości i analizy treści notki odautorskie znajdujące się na początku i na końcu opowiadań. Wyniki przedstawiają procentowy rozkład występujących wątków, ich opis oraz sygnały działań autorów jako nosicieli traumy, na przykład poprzez podkreślanie niezwykłości czasów pandemicznych, poszukiwanie winnego czy refleksje na temat wpływu fikcji fanowskiej na zdrowie psychiczne zarówno twórców, jak i odbiorów.
Dialogiczność w dyskursie naukowym. Analiza form wprowadzania mowy przytaczanej
Authors: Paluch Monika , Rakoczy Anna , Różalska Marianna
Published: October 2022

Przedmiotem artykułu jest dyskurs naukowy, który wraz z dyskursem dydaktyczno-naukowym składa się na styl komunikacji akademickiej. Punktem wyjścia do analizy była jedna z dystynkcji stylu naukowego, a mianowicie dialogiczność przejawiająca się poprzez obecność licznych cytatów i przypisów. Materiał badawczy stanowiła monografia wieloautorska Badanie komunikacji/Projektowanie komunikacji vol. 3 pod redakcją Michała Grecha, Karoliny Lachowskiej, Kamila Olendra i Annette Siemes. Ukazała się ona w 2020 roku w ramach serii wydawniczej „Communication design”, jako rezultat interdyscyplinarnej konferencji naukowej Communication design: badanie i projektowanie komunikacji 9. Monografia składa się ze wstępu oraz 15 artykułów odwołujących się do czterech wybranych obszarów: (sub)kultur, wizerunków i konstruktów, dyskursu i komunikacji oraz praktyki projektowania. Celem badania było zidentyfikowanie, w jaki sposób autorzy tekstów akademickich — studenci, doktoranci, pracownicy naukowi i badawczo-naukowi — operują mową przytaczaną w ramach swojego dyskursu, a więc w publikacjach o charakterze naukowym.
The impact of the COVID-19 pandemic on the assets and reserves of the banking sector
Authors: Puk Emilia
Published: October 2022

The banking sector is a very important part of the financial market. That is why banks, along with the spread of the pandemic, began to implement various strategies and solutions to protect people’s finances against the negative effects of the coronavirus crisis (Flotyński, 2020, 20). Today, it is clear that the pandemic has surprised everyone and the solutions used so far have not been perfect. Therefore, the banking sector requires corrections in current forecasts as well as the preparation of new forecasting models for the financial market. This is particularly important in times of economic, social, and financial instability caused by random events such as the COVID-19 pandemic. The present article examines the distribution mechanisms shaping and influencing the selection of the appropriate class of models depending on the current economic situation of chosen processes important for the banking sector, that is assets and reserves. The author recognizes the mechanisms shaping both processes during a stable period as well as the way in which the pandemic changed these mechanisms, thus affecting the prognostic abilities of the models used. The analysis shows that the Polish banking sector was well prepared for the economic slowdown, but despite this, the COVID-19 pandemic caused some perturbations.
The institution of entering into a lease of a dwelling after the death of the current tenant (Art. 691 of the Civil Code) in the light of the jurisprudence
Authors: Rybak Alicja
Published: October 2022

The aim of this study is to explain how an institution can enter into a lease after the death of the tenant in accordance with Art. 691 of the the Polish Civil Code. The author tries to clarify the wording of Art. 691, which raises questions of interpretation on the basis of case law. In particular, the author undertook the examination of the conditions for entering into the rental relationship of a dwelling after the deceased tenant. Subsequently, the focus was on approximating the premises covered by this standard, then on clarifying the terms “residence” and “other persons to whom the tenant owed maintenance,” and on actual cohabitation with the tenant. The legal proceedings relating to the regulation in question are dealt with next, while the final part describes the possibility of terminating the contract by the rightholder and briefly refers to the provision of Art. 691 para. 5 of the Civil Code.
Optime docuit Donatus
Authors: Fortes Fábio
Published: October 2022

Embora o gramático alexandrino Apolônio Díscolo (c. séc. II d.C.) seja lembrado como o modelo gramatical mais importante para a Ars Prisciani, não menos importantes parecem ser também as fontes latinas com as quais Prisciano dialoga em sua extensa gramática. Assim, também a Ars Donati poderia ser pensada como tendo um papel na construção do pensamento técnico-gramatical de Prisciano. Neste artigo, temos por objetivo oferecer uma abordagem das referências diretas e indiretas a Donato contidas ao longo da Ars Prisciani, bem como analisar o modo pelo qual Prisciano faz uso de exempla oriundos da tradição artigráfica latina, contidos na Ars maior. Pretendemos mostrar que, assim como o Perì syntáxeos de Apolônio Díscolo, também os manuais de Donato (especialmente a Ars maior) parecem ser tomados como modelos para o desenvolvimento da doutrina gramatical desse autor latino. Além disso, pretendemos mostrar que os exempla de Donato são apresentados sob um enquadre teórico diverso, não mais para descrever a Latinitas e os fenômenos a ela associados (como os vícios e virtudes do discurso), mas para compreender a extensão do uso linguístico (usus).
Application Of The Group Investigation Model, Using Whatsapp To Increase Learning Outcomes For Class VI Students Of Sd Negeri Trayu Samigaluh Academic Year 2020/2021
Authors: Widyaningsih Erma
Published: October 2022

The purpose of this study was to improve learning outcomes for grade VI students at SD Negeri Trayu Samigaluh Kulon Progo for the 2020/2021 school year and the ability of teachers to manage learning through the application of the Group Investigation model with WhatsApp Group Classes. This research is a classroom action research. This research was carried out in two cycles, in which each cycle had two meetings covering planning, action, observation, and reflection. The research subjects were students of Class VI SD Negeri Trayu Samigaluh, Kulon Progo Regency. Data and data sources come from students, and the learning process. Data collection techniques through observation and tests. Data analysis with qualitative descriptive technique. The results showed that the application of the Group Investigation model using the WhatsApp Group class could improve the learning outcomes of grade VI students at SD Negeri Trayu Samigaluh for the 2020/2021 school year. It can be seen the increase in cognitive test scores from 35.29% (cycle I) to 58.82% (cycle II). Furthermore, in the management of learning by teachers, the average result was 3.49 (cycle I), with the category "Very Satisfactory", while in Cycle II the average value was obtained at 3.74 with the category "Very Satisfactory".
On the Additive and Subtractive Representation of Even Numbers from Primes
Authors: Shehu Ali , Uka Jetmira
Published: October 2022

We demonstrate a new quantitative method to the sieve of Eratosthenes, which is an alternative to the sieve of Legendre. In this method, every element of a given set is sifted out once only, and therefore, this method is free of the Mobius function and of the parity barrier. Using this method, we prove that every sufficiently large even number is the sum of two primes, and that every even number is the difference of two primes in infinitely many ways.
Virtual Screening and Zebrafish Models in Tandem, for Drug Discovery and Development
Authors: Hernández-Silva David , Alcaraz-Pérez Francisca , Pérez-Sánchez Horacio , Cayuela María Luisa
Published: October 2022

Introduction: The combination of Virtual Screening (VS) techniques with in vivo screening in the zebrafish model is currently being used in tandem for drug development in a faster and more efficient way. Areas covered: We review the different virtual screening techniques, the use of zebrafish as a vertebrate model for drug discovery and the synergy that exists between them. Expert opinion: We highlight the advantages of combining virtual and zebrafish larvae screening for drug discovery. On the one hand, VS is a faster and cheaper tool for searching active compounds and possible candidates for therapy than in vivo screening when processing large compound libraries. On the other hand, zebrafish larvae form a vertebrate model which allows in vivo screening of large amounts of the compounds. Importantly physiology and chemical response are mostly conserved between zebrafish and mammals. The availability of the transgenic and mutant zebrafish lines allows an analysis of a specific phenotype upon treatment along with toxicity, off-target effect, side effects, and dosage. Advantages of VS, in vivo whole animal approach screening, and the screening combinations are also reviewed.
PENGARUH LINGKUNGAN KERJA NON FISIK TERHADAP KINERJA (Studi Pada Pengrajin Sewel Cinta, Socah)
Authors: Indriastutik Veni , Ismail Iriani
Published: October 2022

Socah Village is located in Socah District, Bangkalan Regency. Housewives in Socah Village are very productive because so many home industries are developing, especially the production of snacks. One of them is Sewel. The advantages of Sewel Cinta are tasty with the addition of chili paste and peanuts. To achieve high employees performance, a non-physical work environment is needed. The purpose of this study was to determine the effect of the Non-Physical Work Environment on the Employees Performance. It uses a quantitative approach, with the entire population as respondents as many as 25 employees. Using the multiple linear regression analysis, the results showed that: 1) Supervision (X1) has a positive and significant effect on employees performance (Y). 2) Work Atmosphere (X2) has a positive and significant effect on employees performance (Y). 3) Reward System (X3) has a positive and significant effect on employees.. 4) Good Treatment (X4) has a positive and significant effect on employees performance (Y).. 5) Safety (X5) has a positive and significant effect on employees performance (Y 6) Supervision (X1), Work Atmosphere (X2), Reward System (X3), Good Treatment (X4), and Safety (X5) have a simultaneous effect on employees performance (Y).
Service Quality, Experiential Marketing dan Customer Satisfication Pengguna Gojek
Authors: Putri Nanda Setya , Sarwoko Endi
Published: October 2022

Penelitian bertujuan untuk menganalisis pengaruh service quality dan experiential marketing terhadap customer satisfication pengguna Gojek. Penelitian ini merupakan penelitian explanatory research dengan pendekatan kuantitatif. Penelitian dilakukan padapelanggan Go-jek di Kota Malang, menggunakan sampel sebanyak 145 pelanggan dengan menggunakan metode accidental sampling. Teknik pengumpulan data menggunakan kuesionerkemudian dianalisis menggunakan analisis Regresi linear berganda dengan bantuan SPSS versi 21. Hasil penelitian ini mengkonfirmasi bahwa service quality dan experiential marketing merupakan faktor yang memengaruhi customer satisfaction pengguna Gojek. Penelitian lebih lanjut diperlukan pada penyedia jasa sejenis seperti Grab untuk pengembangan penelitian ini.
PENGARUH MEDIA LOOSE PART TERHADAP KEMAMPUAN PRA MENULIS ANAK PADA KELOMPOK B
Authors: Leonia Rizqy Aisyah , Handayani Tutut , Putri Yecha Febrieanitha
Published: October 2022

Tujuan penelitian ini adalah untuk mengetahui apakah penggunaan media loose part berpengaruh terhadap kemampuan menulis anak kelompok B di Tebing Tinggi. Subjek penelitian ini adalah 20 anak yang dibagi menjadi dua kelompok yaitu kelompok eksperimen dan kelompok kontrol. Penelitian ini menggunakan metode kuantitatif melalui metode eksperimen, dan menggunakan desain eksperimen semu dan desain kelompok kontrol pre-test dan post-test. Teknik pengumpulan data yang digunakan adalah observasi, tes dan wawancara. Teknik analisis data dalam bentuk statistik non parametrik uji tingkat Kolmogrov Smirnov dengan data hasil penelitian pretest dan posttest. Hasil penelitian ini menunjukkan bahwa rata-rata kemampuan menulis anak kelas eksperimen dan kelas kontrol adalah 42,5 dan 40,7, sedangkan nilai post-test anak kelas eksperimen dan kelas kontrol rata-rata 82 dan 72,3. nilai adalah 0,000, dan kurang dari 0,05 menunjukkan efek.
SISTEM PEMBELAJARAN DI TK SATU ATAP LIMA PULUH SELAMA MASA PANDEMI
Authors: Munasti Kholida , Na'imah Na'imah
Published: October 2022

The epidemic of coronavirus disease 19 (Covid-19) has dominated the world for about two years. This disrupts all human activity, one of which is in the field of education. Learning during a pandemic really worries teachers and parents  about  learning that schools provide students with an online system. Therefore, researchers want to see the online learning process during a pandemic. The purpose of this study was to find a learning system for the TK Satu Atap Lima Puluh in Kabupaten Batu Bara, Sumatera Utara during the Covid-19 pandemic. The method chosen in this study is qualitatively descriptive. Observations and interviews were used to collect data. The respondents to the survey were parents of one teacher and four students. The data analysis technique used is to describe exactly what the researcher receives. The  research phase begins with observations, interviews,  data reductions, and data analysis. The results showed that the learning process still followed the demands of parents and schools, the learning media did not vary much even mostly only used blackboards and markers and the teacher only explained what was written. Researchers recommend that this research  be done on a larger scale so that more meaningful learning can be applied to other educational environments.
PEMANFAATAN MEDIA SOSIAL WHATSAPP SEBAGAI MEDIA PEMBELAJARAN DI MASA PANDEMI UNTUK ANAK USIA DINI
Authors: Putri Yuniar Eka , Elita Rd Funny Mustikasari , Gemiharto Ilham
Published: October 2022

Kebijakan social distancing dan physical distancing yang ditetapkan pemerintah dalam rangka memutus penyebaran Covid-19 memberikan dampak pada kegiatan belajar mengajar di Pendidikan Anak Usia Dini (PAUD). Proses belajar mengajar pada anak usia dini yang cenderung melibatkan tatap muka, interaksi dan keterlibatan secara langsung harus dilakukan melalui pembelajaran online atau daring. Diperlukan sebuah media pembelajaran yang dapat menciptakan atmosfer sekolah walaupun kegiatan sekolah ditutup, yaitu melalui pemanfaatan media sosial WhatsApp karena dinilai sangat mudah digunakan bagi orang tua  dan memiliki banyak fitur yang memudahkan kegiatan belajar mengajar bagi anak usia dini. Penelitian ini mengambil tujuan untuk melihat bagaimana dan sejauh apa pemanfaatan media sosial WhatsApp dapat mengubah perilaku belajar anak usia dini di masa pandemi. Penelitian ini menggunakan metode kualitatif deskriptif dengan pendekatan studi kasus dan mengambil lokus penelitian di TPA Bale Bermain Anwari Jakarta Timur. Hasil dari penelitian ini adalah penggunaan media sosial WhatsApp dinilai cukup efektif sebagai media pembelajaran daring karena dapat menjadi sarana edukasi dan evaluasi dari kegiatan belajar mengajar bagi anak usia dini. Namun demikian, penggunaan jaringan internet masih menjadi kendala bagi guru dan orang tua  sehingga membutuhkan kebijakan baru dalam dunia pendidikan selama masa pandemi agar tetap tercipta pendidikan Indonesia yang bermutu dan berkualitas.
Donna Orange: Ética, Diálogo y Falibilismo
Authors: Aula Carmona Borja
Published: October 2022

The claims that Donna M. Orange puts forward in her general work, are the result of the waves of meditations drawn from her interest in philosophy and which she intends to recover for contemporary analytical practice. The primordial ethics of Emmanuel Lévinas, the dialogical hermeneutics of Hans-Georg Gadamer, applied phenomenology, contextualism and constricted fallibilism are some of the inspirations that Orange transfers to the trauma clinic. In this paper we will explore the meaning of these sensibilities that seek to enlighten the analyst in his untamed task.
Duelo egótico por el cuerpo doliente. Estudio fenomenológico y psicoanalítico del dolor intenso
Authors: Sánchez Sánchez Teresa
Published: October 2022

The experience of an intense and prolonged physical pain reported by Rafael Argullol in his book "Davalú or pain" promotes a phenomenological and psychoanalytic analysis of mourning (combat) and mourning (elaboration within the self) due to loss of health, strength and autonomy. Pain is the cry of the body that remains in a prementalizing and meaningless space which challenges the environment but it remains outside of subjectivity and it breaks the link with the others, especially when it is located only in the body and it does not include the person as intentional being. From its radical corporeality, the pain closes to (corners) the self, it annihilates the previous identity and it reveals our maximum vulnerability and defenselessness. From the egotic retreat to a narcissism without language, the self plunges into a self-mourning that only ends when the pain stops. There is no pact with the suffering body’s ache, especially if it cannot be transformed into suffering
The urban regulation of rural land from the perspective of the new Law for the Promotion of Territorial Sustainability in Andalusia (Andalusian Land Law)
Authors: Galacho Jiménez Federico Benjamín , Reyes Corredera Sergio
Published: October 2022

Since their inception, various urban planning laws have focused on meeting the growth needs of cities, with urban planning as a discipline paying minimal attention to rural settlement planning. It can, therefore sound clichéd to say that urban planning legislation has been mainly concerned with regulating urban and developable land, with residual or negative status being given to undevelopable or rural land. This has had major territorial impacts that continue to this day. The proposed subject of this paper is considered timely and topical, and its main objective is to analyse whether the planning instruments proposed in the Law for the Promotion of Territorial Sustainability in Andalusia (LISTA, acronym in Spanish) for rural settlements and scattered buildings can help regulate rural land dynamics in Andalusia. To do so, we will first model the patterns of settlement formation and isolated dwellings on rural land using geostatistical methods, and then carry out an analysis of the provisions of these latest rural land management laws, which will affect the planning regulations of this land in the coming years.
Alveolar-Capillary Region Exposure (ACRE) Model
Authors: Vitucci Eva CM , McCullough Shaun D.
Published: October 2022

This exposure model was designed as an in vitro representation of trans-alveolar effects of airway particulate matter exposures on microvascular endothelial cells in the alveolar capillary region of the lung. The alveolar epithelial cells are represented by the NCI-H441 cell line, interstitial fibroblasts are represented by the IMR90 cell line, and microvascular endothelial cells are represented by the HULEC cell line. Disclaimer: The contents of this article have been reviewed by the US Environmental Protection Agency and approved for publication and do not necessarily represent Agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendations for use. NOTE: There is a consolidated PDF version of this protocol in the supplementary files section below.
A metabolomic protocol for investigating the gut microbiome
Authors: Han Shuo , Guiberson Emma R. , Sonnenburg Justin L.
Published: October 2022

A significant hurdle that has limited progress in microbiome science has been identifying and studying the diversity of metabolites produced by the gut microbes. Gut microbial metabolism produces thousands of difficult-to-identify metabolites, which present a challenge to study their roles in host biology. Over the recent years, mass spectrometry-based metabolomics has become one of the core technologies for identifying small metabolites. However, metabolomics expertise, ranging from sample preparation, instrument use, to data analysis, is often lacking in academic labs. Most targeted metabolomics methods provide high levels of sensitivity and quantification, while they are limited to a panel of predefined molecules that may not be informative to microbiome-focused studies. Here we have developed a gut microbe-focused, wide-spectrum, targeted metabolomic protocol using Liquid Chromatography-Mass Spectrometry (LC-MS) and bioinformatic analysis. This protocol enables users to carry out experiments from sample collection to data analysis, only requiring access to a LC-MS instrument, which is often available at local core facilities. By applying this protocol to samples containing human gut microbial metabolites, spanning from culture supernatant to human biospecimens, our approach enables high confidence identification of >800 metabolites. We expect this protocol will lower the barrier in tracking gut bacterial metabolism in vitro and in mammalian hosts, propelling hypothesis-driven mechanistic studies and accelerating our understanding of the gut microbiome at the chemical level.
Association of job characteristics and burnout of healthcare workers in different positions in Rural China: a cross-sectional study
Authors: Zhang Mei , Li Sangsang , Han Dan , Wu Yunyi , Zhao Jie , Liao Hui , Ma Ying , Yan Chaoyang , Wang Jing
Published: October 2022

Background
Health workers in rural primary care systems are at increased risk of job burnout, but their associations with different positions have received scant attention in the literature. Thus, this study aims to measure job burnout in different positions in rural China and identify the associated factors of job burnout in different positions.
Methods
A cross-sectional study was conducted in six provincial regions in China. A total of 15,925 PC providers participated in this study, and job burnout was measured using the Maslach Burnout Inventory-General Scale. Multilevel regression analyses were used in examining factors potentially associated with job burnout in different positions.
Results
Overall, more than half of providers in different positions suffered from moderate burnout. The degree of job burnout varied among different positions. Middle managers showed higher levels personal stress, and the general staff showed the lowest interpersonal and self-evaluation dimensions of burnout. Job duty, job capability, job treatment, and career advancement in different positions are potential factors affecting these results.
Conclusions
The degree of job burnout varied among different positions in health systems. Interventions aimed at improving communication skills, professional skills, and salary adjustments may be promising strategies for alleviating burnout in different positions and improving health system performance.
Does neuroprotective magnesium sulfate treatment impact short-term outcomes in preterm infants?
Authors: Bekmez Buse Ozer , Kutman Hayriye Kanmaz , Oguz Yuksel , uygur Dilek , Elbayiyev Sarkhan , CANPOLAT FUAT EMRE , Oguz Serife , Tayman Cuneyt
Published: October 2022

Objective: Magnesium sulfate (MgSO4) treatment is widely used for the fetal neuro-protective purpose along with the controversy concerning side effects. A scant number of studies searched the impact of different cumulative maternal doses and neonatal serum Mg levels on short-term neonatal morbidity and mortality. We opted to carry out a study to determine the impact of neonatal serum Mg levels on immediate neonatal outcomes.
Study design: This prospective observational study was conducted between 2017 and 2021. Antenatal MgSO4 was used for the neuro-protective purpose only during the study period. Inborn preterm infants delivered between 23 and 32 weeks of gestation were enrolled consecutively. Routine neonatal serum Mg sampling was performed at the 6th hour of life. A neonatal Mg concentration of 2.5 mg/dl was used to classify MgSO4 exposed patients into two groups. Another analysis was performed between babies whose mothers were exposed to MgSO4 and those without. Finally, the groups were compared regarding neonatal outcomes.
Result: Of the 584 babies, 310 received antenatal MgSO4. The birth weight was significantly lower in the MgSO4 exposed group (1113±361g vs. 1202±388g) (p=0.005). Antenatal corticosteroid usage and intrauterine growth restriction were also noted to be higher. MgSO4 group was more likely to have bronchopulmonary dysplasia, longer duration of invasive ventilation, necrotizing enterocolitis, patent ductus arteriosus, delayed full enteral nutrition, and feeding intolerance (p<0.05). MgSO4 treatment was found to be an independent risk factor for feeding intolerance (OR 2.09 95% CI 1.2-3.6, p=0.008). Furthermore Serum Mg level was significantly correlated with feeding intolerance (r =0.21, p=0.002).
Conclusion: This study highlighted the effect of MgSO4 treatment and the the potential superiority of serum Mg level as a predictor of immediate neonatal outcomes, particularly delayed full enteral nutrition and feeding intolerance. Further studies are warranted to ascertain the optimal serum Mg concentration of preterm infants in early life that provides maximum benefit with minimal side effects.