bluuebunny/crossref_metadata_2025 huggingface dataset:
In Silico Identification and Experimental Validation of (−)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator
Authors: D’Aniello Enrico , Iannotti Fabio Arturo , Falkenberg Lauren G. , Martella Andrea , Gentile Alessandra , De Maio Fabrizia , Ciavatta Maria Letizia , Gavagnin Margherita , Waxman Joshua S. , Di Marzo Vincenzo , Amodeo Pietro , Vitale Rosa Maria
Published: February 2019

The nuclear receptors (NRs) RARα, RXRα, PPARα, and PPARγ represent promising pharmacological targets for the treatment of neurodegenerative diseases. In the search for molecules able to simultaneously target all the above-mentioned NRs, we screened an in-house developed molecular database using a ligand-based approach, identifying (−)-Muqubilin (Muq), a cyclic peroxide norterpene from a marine sponge, as a potential hit. The ability of this compound to stably and effectively bind these NRs was assessed by molecular docking and molecular dynamics simulations. Muq recapitulated all the main interactions of a canonical full agonist for RXRα and both PPARα and PPARγ, whereas the binding mode toward RARα showed peculiar features potentially impairing its activity as full agonist. Luciferase assays confirmed that Muq acts as a full agonist for RXRα, PPARα, and PPARγ with an activity in the low- to sub-micromolar range. On the other hand, in the case of RAR, a very weak agonist activity was observed in the micromolar range. Quite surprisingly, we found that Muq is a positive allosteric modulator for RARα, as both luciferase assays and in vivo analysis using a zebrafish transgenic retinoic acid (RA) reporter line showed that co-administration of Muq with RA produced a potent synergistic enhancement of RARα activation and RA signaling.
Development of a Mucoadhesive and In Situ Gelling Formulation Based on κ-Carrageenan for Application on Oral Mucosa and Esophagus Walls. I. A Functional In Vitro Characterization
Authors: Vigani Barbara , Faccendini Angela , Rossi Silvia , Sandri Giuseppina , Bonferoni Maria Cristina , Gentile Matteo , Ferrari Franca
Published: February 2019

Oral mucositis and esophagitis represent the most frequent and clinically significant complications of cytoreductive chemotherapy and radiotherapy, which severely compromise the patient quality of life. The local application of polymeric gels could protect the injured tissues, alleviating the most painful symptoms. The present work aims at developing in situ gelling formulations for the treatment of oral mucositis and esophagitis. To reach these targets, κ-carrageenan (κ-CG) was selected as a polymer having wound healing properties and able to gelify in the presence of saliva ions, while hydroxypropyl cellulose (HPC) was used to improve the mucoadhesive properties of the formulations. CaCl2 was identified as a salt able to enhance the interaction between κ-CG and saliva ions. Different salt and polymer concentrations were investigated in order to obtain a formulation having the following features: (i) low viscosity at room temperature to facilitate administration, (ii) marked elastic properties at 37 °C, functional to a protective action towards damaged tissues, and (iii) mucoadhesive properties. Prototypes characterized by different κ-CG, HPC, and CaCl2 concentrations were subjected to a thorough rheological characterization and to in vitro mucoadhesion and washability tests. The overall results pointed out the ability of the developed formulations to produce a gel able to interact with saliva ions and to adhere to the biological substrates.
Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products
Authors: Floresta Giuseppe , Amata Emanuele , Gentile Davide , Romeo Giuseppe , Marrazzo Agostino , Pittalà Valeria , Salerno Loredana , Rescifina Antonio
Published: February 2019

Over-regulation of Heme oxygenase 1 (HO-1) has been recently identified in many types of human cancer, and in these cases, poor clinical outcomes are normally reported. Indeed, the inhibition of HO-1 is being considered as an anticancer approach. Imidazole scaffold is normally present in most of the classical HO-1 inhibitors and seems indispensable to the inhibitory activity due to its strong interaction with the Fe(II) of the heme group. In this paper, we searched for new potentially HO-1 inhibitors among three different databases: Marine Natural Products (MNP), ZINC Natural Products (ZNP) and Super Natural II (SN2). 484,527 compounds were retrieved from the databases and filtered through four statistical/computational filters (2D descriptors, 2D-QSAR pharmacophoric model, 3D-QSAR pharmacophoric model, and docking). Different imidazole-based compounds were suggested by our methodology to be potentially active in inhibiting the HO-1, and the results have been rationalized by the bioactivity of the filtered molecules reported in the literature.
Association of Physicians’ Self-Compassion with Work Engagement, Exhaustion, and Professional Life Satisfaction
Authors: Babenko Oksana , Mosewich Amber D. , Lee Ann , Koppula Sudha
Published: February 2019

Self-compassion has shown promise as an adaptive resource for coping with uncertainties and challenges. This study examined the relationship between self-compassion and professional wellbeing (work engagement, exhaustion, and professional life satisfaction) of physicians, who frequently face uncertainties and challenges in their clinical practice. Fifty-seven practicing physicians in Canada participated in the study. Overall, 65% of the participants were female; 47% were in the early-career stage; 49% were family medicine (FM) physicians, with the rest being non-FM specialists. It was hypothesized that (a) self-compassionate physicians would experience greater work engagement and less exhaustion from work than physicians reporting lower self-compassion and (b) self-compassionate physicians would experience greater professional life satisfaction through their greater work engagement and less exhaustion than physicians reporting lower self-compassion. Sequential regression analyses were performed. The results confirmed the hypothesized associations, indicating that self-compassionate physicians experienced more positive work engagement, felt less emotionally, physically, and cognitively exhausted due to work demands, and were more satisfied with their professional life than physicians who exhibited less compassion toward themselves in uncertain and challenging times. Future studies are needed to determine optimal ways to support practicing physicians and medical trainees in becoming more self-compassionate for their enhanced wellbeing and, ultimately, for the provision of effective patient care.
Thermal-Induced Phase Transformation Behavior of NiTiNb Hypoeutectic, Eutectic, and Hypereutectic Alloys
Authors: Yin Huilin , Ma Guohua , Fan Qichao , Wang Yingying , Huang Shuke , Yi Yong
Published: February 2019

In the present work, three NiTiNb alloys with nominal compositions of Ni50–x/2Ti50–x/2Nbx (x = 18, 20 and 22, at.%) were prepared. The microstructure, thermal-induced phase transformation, and phase components of NiTiNb hypoeutectic, eutectic, and hypereutectic alloys were investigated by scanning electron microscopy coupled with energy dispersive spectrometer (SEM/EDS), differential scanning calorimetry (DSC), and X-ray diffraction (XRD), respectively. Two peaks occurred in the DSC curves of Ni41Ti41Nb18 solution at 750 and 850 °C. The different microstructures of NiTiNb hypoeutectic, eutectic and hypereutectic alloys, the occurrence of two peaks in the DSC curves, and the characteristic of martensite transformation temperature were analyzed and discussed. The results show that different Nb content leads to different microstructures of Ni50–x/2Ti50–x/2-Nbx alloys. Moreover, the difference of Ni/Ti ratio between the primary NiTi matrix and NiTi in eutectic structure strongly influenced the phase transformation behavior that the DSC curves of Ni41Ti41Nb18 alloy show two peaks. Furthermore, under the same solution treatment, the Ni40Ti40Nb20 alloy has a lower Ms than the other two alloys. The Ms has a tendency to decrease with an increase in solution temperature.
Identification of the Quasi-Static and Dynamic Behaviour of Projectile-Core Steel by Using Shear-Compression Specimens
Authors: Duplan Yannick , Saletti Dominique , Forquin Pascal
Published: February 2019

Armour-Piercing (AP) projectiles constitute a major threat to be considered for the design of bi-layer-armour configurations constructed using a ceramic front plate backed with a composite/metal layer. When they are not made of tungsten-carbide the cores of these projectiles are made of hard steel, and are the main part that defines the penetration performance of the projectile. However, due to specific testing difficulties, the dynamic behaviour of these high-strength steel AP projectiles has not been investigated in sufficient detail. In this study, a detailed experimental investigation of the dynamic behaviour of the steel used for the steel core of 7.62 mm BZ-type AP projectiles was analysed through the use of Shear-Compression Specimens (SCS). In this study, results from both quasi-static and dynamic experiments were examined. The data processing method employed was set and validated based on numerical simulations. Both quasi-static and dynamic SCS experiments were done with the steel tested which clearly indicated the steel cores exhibit a very high elastic limit, little strain-hardening, and very little strain-rate sensitivity despite the wide range of strain-rates considered. This experimental characterisation paves the way to the numerical modelling for the analysis of ballistic impact of 7.62 mm AP projectile against lightweight armour configurations.
Experimental and Numerical Study of an Automotive Component Produced with Innovative Ceramic Core in High Pressure Die Casting (HPDC)
Authors: Cornacchia Giovanna , Dioni Daniele , Faccoli Michela , Gislon Claudio , Solazzi Luigi , Panvini Andrea , Cecchel Silvia
Published: February 2019

Weight reduction and material substitution are increasing trends in the automotive industry. High pressure die casting (HPDC) is the conventional casting technology for the high volume production of light alloys; it has recently found wide application in the manufacturing of critical components, such as complex and thin geometry automotive parts. However, the major restriction of this affordable technology is the difficulty to design and realize hollow sections or components with undercuts. An innovative way to further increase the competitiveness of HPDC is to form complex undercut shaped parts through the use of new lost cores that are able endure the high pressures used in HPDC. This paper investigates the use of innovative ceramic lost cores in the production of a passenger car aluminum crossbeam by HPDC. Firstly, process and structural simulations were performed to improve the crossbeam design and check the technology features. The results led to the selection of the process parameters and the production of some prototypes that were finally characterized. These analyses demonstrate the feasibility of the production of hollow components by HPDC using ceramic cores.
Microstructure and Hot Deformation Behaviour of a Novel Zr-Alloyed High-Boron Steel
Authors: Prosviryakov Alexey , Mondoloni Baptiste , Churyumov Alexander , Pozdniakov Andrey
Published: February 2019

A novel corrosion-resistant steel with high boron content is investigated in this paper. Three stages during crystallisation of the steel are revealed. The positive influence of Zr addition on the microstructure and mechanical properties after hot deformation is shown. The Zr-alloyed steel demonstrates hot deformation without fracturing in the temperature range of 1273–1423 K, and in the strain rate range of 0.1–10 s−1, despite the high volume of brittle borides. The processes of ferrite recrystallisation and boride structure fragmentation occur during hot deformation, promoting the appearance of a peak on stress–strain curves.
Micro-Laser-Induced Breakdown Spectroscopy: A Novel Approach Used in the Detection of Six Rare Earths and One Transition Metal
Authors: Martin Madhavi , Hamm Daniel , Martin Samir , Allman Steve , Bell Gary , Martin Rodger
Published: February 2019

Laser-induced breakdown spectroscopy (LIBS) was undertaken using an instrument which used a high-powered microscope to deliver the light and tightly focused the low energy laser beam onto the surface of a solid sample. A micro-plasma was generated on the surface of the sample under test even though the amount of energy/pulse from a beam of 532 nm was <1 mJ. Rare earth elements such as europium, gadolinium, lanthanum, neodymium, praseodymium, samarium, and a transition metal, yttrium, were tested. These elements are important in nuclear fission reactions especially for estimation of actinide masses for non-proliferation “safeguards”. Each element was mixed in the graphite matrix in different percentages from 1% to 50% by weight and the LIBS spectra were obtained for each composition as well as after mixing each element in the same amount using oxides of the elements. The data for the 5% mixture of the rare earth elements with graphite powder along with the transition metal has been presented in this article. A micro-LIBS approach was used to demonstrate that these rare earth elements can be identified individually and in a complex mixture in glove boxes in which the microscope LIBS instrument is housed in a nuclear research environment.
Polyalcohols as Hydrogen-Bonding Donors in Choline Chloride-Based Deep Eutectic Solvents for Extraction of Xanthones from the Pericarp of Garcinia mangostana L.
Authors: Mulia Kamarza , Fauzia Farah , Krisanti Elsa Anisa
Published: February 2019

Mangosteen (Garcinia mangostana L.) is a fruit that is rich in xanthones, utilized as health supplements or additives in food products due to their high antioxidant activities. Choline chloride (ChCl)-based deep eutectic solvents (DESs) with polyalcohols (ethylene glycol, glycerol, propanediols, and butanediols) as hydrogen bonding donors (HBDs) were used to extract the xanthones from the pericarp of mangosteen. DESs with 1,2-propanediol, 1,3-propanediol, and 1,2-butanediol as HBDs (ChCl to HBD mole ratio of 1:3) afforded the highest extraction yields (2.40-2.63%) of α-mangostin, the most abundant component that represents xanthones. These DESs have intermediate Nile Red polar parameter values similar to that of ethanol and provide extraction yields with a quadratic dependence on the polar parameter. Polarity and viscosity, the important physicochemical properties to consider in the selection of DES as an extraction solvent, could be adjusted based on the consideration of the molecular structure of the polyalcohols. The following factors qualifies the ChCl-1,2-propanediol DES as a designer solvent for green extraction: It is selected from a set of DESs having a homologous class of HBDs to deliver the highest α-mangostin extraction yield, its extract composition similar to that obtained using ethanol, it has low or negligible vapor pressure, both of its components are generally recognized as safe chemicals so that direct utilization of a DES extract is possible, and this DES is used for utilization of agricultural waste products as the resource of bioactive compounds.
First-Principles Calculations of Angular and Strain Dependence on Effective Masses of Two-Dimensional Phosphorene Analogues (Monolayer α-Phase Group-IV Monochalcogenides MX)
Authors: Xu Yuanfeng , Xu Ke , Zhang Hao
Published: February 2019

Group IV monochalcogenides M X (M = Ge, Sn; X = S, Se)-semiconductor isostructure to black phosphorene-have recently emerged as promising two-dimensional materials for ultrathin-film photovoltaic applications owing to the fascinating electronic and optical properties. Herein, using first-principles calculations, we systematically investigate the orbital contribution electronic properties, angular and strain dependence on the carrier effective masses of monolayer M X . Based on analysis on the orbital-projected band structure, the VBMs are found to be dominantly contributed from the p z orbital of X atom, while the CBM is mainly dominated by p x or p y orbital of M atom. 2D SnS has the largest anisotropy ratio due to the lacking of s orbital contribution which increases the anisotropy. Moreover, the electron/hole effective masses along the x direction have the steeper tendency of increase under the uniaxial tensile strain compared to those along y direction.
Therapeutic Radiometals: Worldwide Scientific Literature Trend Analysis (2008–2018)
Authors: Uccelli Licia , Martini Petra , Cittanti Corrado , Carnevale Aldo , Missiroli Loretta , Giganti Melchiore , Bartolomei Mirco , Boschi Alessandra
Published: February 2019

Academic journals have published a large number of papers in the therapeutic nuclear medicine (NM) research field in the last 10 years. Despite this, a literature analysis has never before been made to point out the research interest in therapeutic radionuclides (RNs). For this reason, the present study aims specifically to analyze the research output on therapeutic radiometals from 2008 to 2018, with intent to quantify and identify global trends in scientific literature and emphasize the interdisciplinary nature of this research field. The data search targeted conventional (131I, 90Y, 177Lu, 188Re, 186Re, 153Sm, 89Sr, 186Er) and emergent (67Cu, 47Sc, 223Ra, 166Ho, 161Tb, 149Tb, 212Pb/212Bi, 225Ac, 213Bi, 211At, 117mSn) RNs. Starting from this time frame, authors have analyzed and interpreted this scientific trend quantitatively first, and qualitatively after.
Small Molecule Docking of DNA Repair Proteins Associated with Cancer Survival Following PCNA Metagene Adjustment: A Potential Novel Class of Repair Inhibitors
Authors: Peterson Leif E.
Published: February 2019

Natural and synthetic small molecules from the NCI Developmental Therapeutics Program (DTP) were employed in molecular dynamics-based docking with DNA repair proteins whose RNA-Seq based expression was associated with overall cancer survival (OS) after adjustment for the PCNA metagene. The compounds employed were required to elicit a sensitive response (vs. resistance) in more than half of the cell lines tested for each cancer. Methodological approaches included peptide sequence alignments and homology modeling for 3D protein structure determination, ligand preparation, docking, toxicity and ADME prediction. Docking was performed for unique lists of DNA repair proteins which predict OS for AML, cancers of the breast, lung, colon, and ovaries, GBM, melanoma, and renal papillary cancer. Results indicate hundreds of drug-like and lead-like ligands with best-pose binding energies less than −6 kcal/mol. Ligand solubility for the top 20 drug-like hits approached lower bounds, while lipophilicity was acceptable. Most ligands were also blood-brain barrier permeable with high intestinal absorption rates. While the majority of ligands lacked positive prediction for HERG channel blockage and Ames carcinogenicity, there was a considerable variation for predicted fathead minnow, honey bee, and Tetrahymena pyriformis toxicity. The computational results suggest the potential for new targets and mechanisms of repair inhibition and can be directly employed for in vitro and in vivo confirmatory laboratory experiments to identify new targets of therapy for cancer survival.
On-Line Raman Spectroscopic Study of Cytochromes’ Redox State of Biofilms in Microbial Fuel Cells
Authors: Krige Adolf , Sjöblom Magnus , Ramser Kerstin , Christakopoulos Paul , Rova Ulrika
Published: February 2019

Bio-electrochemical systems such as microbial fuel cells and microbial electrosynthesis cells depend on efficient electron transfer between the microorganisms and the electrodes. Understanding the mechanisms and dynamics of the electron transfer is important in order to design more efficient reactors, as well as modifying microorganisms for enhanced electricity production. Geobacter are well known for their ability to form thick biofilms and transfer electrons to the surfaces of electrodes. Currently, there are not many “on-line” systems for monitoring the activity of the biofilm and the electron transfer process without harming the biofilm. Raman microscopy was shown to be capable of providing biochemical information, i.e., the redox state of C-type cytochromes, which is integral to external electron transfer, without harming the biofilm. In the current study, a custom 3D printed flow-through cuvette was used in order to analyze the oxidation state of the C-type cytochromes of suspended cultures of three Geobacter sulfurreducens strains (PCA, KN400 and ΔpilA). It was found that the oxidation state is a good indicator of the metabolic state of the cells. Furthermore, an anaerobic fluidic system enabling in situ Raman measurements was designed and applied successfully to monitor and characterize G. sulfurreducens biofilms during electricity generation, for both a wild strain, PCA, and a mutant, ΔS. The cytochrome redox state, monitored by the Raman peak areas, could be modulated by applying different poise voltages to the electrodes. This also correlated with the modulation of current transferred from the cytochromes to the electrode. The Raman peak area changed in a predictable and reversible manner, indicating that the system could be used for analyzing the oxidation state of the proteins responsible for the electron transfer process and the kinetics thereof in-situ.
Apricot Kernel Extract and Amygdalin Inhibit Urban Particulate Matter-Induced Keratoconjunctivitis Sicca
Authors: Hyun Soo-Wang , Kim Junghyun , Park Bongkyun , Jo Kyuhyung , Lee Tae Gu , Kim Jin Sook , Kim Chan-Sik
Published: February 2019

Exposure to particulate matter is a risk factor for various ocular surface diseases, including keratoconjunctivitis sicca (KCS). In this study, we investigated the protective effects of apricot kernel extract (AKE) and its bioactive compound, amygdalin, on KCS induced by exposure to urban particulate matter (UPM). In the in vivo experiments, eye drops containing 0.5 mg/mL AKE (AKE-0.5) or 1 mg/mL AKE (AKE-1) were administered directly into the eyes of female rats after UPM exposure. Additionally, the effect of AKE and amygdalin on matrix metalloproteinases (MMPs) activity and the expressions of inflammatory factors, including tumor necrosis factor (TNF)-α and interleukin (IL)-6, was investigated in conjunctival epithelial cells in vitro. Topical administration of AKE-1 attenuated UPM exposure-induced reduction of tear secretion. Both AKE-0.5 and AKE-1 inhibited UPM exposure-induced corneal epithelial damage and irregularity. AKE also protected against UPM exposure-induced disruption of the mucin-4 layer on the ocular surface. In addition, AKE and amygdalin prevented UPM-induced activation of MMPs and upregulation of TNF-α and IL-6 in conjunctival epithelial cells. Therefore, AKE may have protective effects against UPM exposure-induced KCS via the inhibition of MMPs and inflammation. The pharmacological activities of AKE may be in part due to its bioactive compound, amygdalin.
Biosynthesized Highly Stable Au/C Nanodots: Ideal Probes for the Selective and Sensitive Detection of Hg2+ Ions
Authors: Venkateswarlu Sada , Govindaraju Saravanan , Sangubotla Roopkumar , Kim Jongsung , Lee Min-Ho , Yun Kyusik
Published: February 2019

The enormous ongoing industrial development has caused serious water pollution which has become a major crisis, particularly in developing countries. Among the various water pollutants, non-biodegradable heavy metal ions are the most prevalent. Thus, trace-level detection of these metal ions using a simple technique is essential. To address this issue, we have developed a fluorescent probe of Au/C nanodots (GCNDs-gold carbon nanodots) using an eco-friendly method based on an extract from waste onion leaves (Allium cepa-red onions). The leaves are rich in many flavonoids, playing a vital role in the formation of GCNDs. Transmission electron microscopy (TEM) and Scanning transmission electron microscopy-Energy-dispersive X-ray spectroscopy (STEM-EDS) elemental mapping clearly indicated that the newly synthesized materials are approximately 2 nm in size. The resulting GCNDs exhibited a strong orange fluorescence with excitation at 380 nm and emission at 610 nm. The GCNDs were applied as a fluorescent probe for the detection of Hg2+ ions. They can detect ultra-trace concentrations of Hg2+ with a detection limit of 1.3 nM. The X-ray photoelectron spectroscopy results facilitated the identification of a clear detection mechanism. We also used the new probe on a real river water sample. The newly developed sensor is highly stable with a strong fluorescent property and can be used for various applications such as in catalysis and biomedicine.
Israelite Temples: Where Was Israelite Cult Not Practiced, and Why
Authors: Faust Avraham
Published: February 2019

Most scholars in the late 20th and early 21st century believed that cultic activity in the kingdoms of Israel and Judah was practiced in various temples that were scattered throughout the kingdoms. Still, a detailed study of the archaeological evidence on Israelite cult reveals that Israelite cultic buildings were extremely rare, both in absolute terms and when compared to other ancient Near Eastern societies, suggesting that cultic activity in temples was the exception rather than the norm and that typical Israelite cult was practiced in the household and in other, non-temple settings. Hence, the evidence suggests that rather than viewing temples, like the one in Arad, as exemplifying typical cultic activity, they should be viewed as exceptions that require a special explanation. The first part of the article develops and updates the suggestion, first raised about ten years ago, that Israelite temples were indeed extremely rare. Given the ancient Near Eastern context, however, such practices seems to be exceptional, and the second part of the article will therefore explain why was such a unique pattern not identified in the past, and will suggest a possible explanation as to how was such an outstanding practice developed and adopted.
Use of SMAP Soil Moisture and Fitting Methods in Improving GPM Estimation in Near Real Time
Authors: Zhang Zhi , Wang Dagang , Wang Guiling , Qiu Jianxiu , Liao Weilin
Published: February 2019

Satellite-based precipitation products have been widely used in a variety of fields. However, near real time products still contain substantial biases compared with the ground data. Recent studies showed that surface soil moisture can be utilized in improving rainfall estimation as it reflects recent precipitation. In this study, soil moisture data from Soil Moisture Active Passive (SMAP) satellite and observation-based fitting are used to correct near real time satellite-based precipitation product Global Precipitation Measurement (GPM) in mainland China. The particle filter is adopted to assimilate the SMAP soil moisture into a simple hydrological model, the antecedent precipitation index (API) model; three fitting methods—i.e., linear, nonlinear, and cumulative distribution function (CDF) fitting corrections—both separately and in combination with the SMAP soil moisture data, are then used to correct GPM. The results show that the soil moisture-based correction significantly reduces the root mean square error (RMSE) and mean absolute errors (BIAS) of the original GPM product in most areas of China. The median RMSE value for daily precipitation over China is decreased by approximately 18% from 5.25 mm/day for the GPM estimates to 4.32 mm/day for the soil moisture corrected estimates, and the median BIAS value is decreased by approximately 13% from 2.03 mm/day to 1.76 mm/day. The fitting correction method alone also improves GPM, although to a lesser extent. The best performance is found when the SMAP soil moisture assimilation is combined with the linear fitting of observed precipitation, with a median RMSE of 4.00 mm/day and a BIAS of 1.69 mm/day. Despite significant reductions to the biases of the satellite precipitation product, none of these methods is effective in improving the correlation between the satellite product and observational reference. Leaf area index and the frequency of the SMAP overpasses are among the potential factors influencing the correction effect. This study highlights that combining soil moisture and historical precipitation information can effectively improve satellite-based precipitation products in near real time.
FeinPhone: Low-cost Smartphone Camera-based 2D Particulate Matter Sensor
Authors: Budde Matthias , Leiner Simon , Köpke Marcel , Riesterer Johannes , Riedel Till , Beigl Michael
Published: February 2019

Precise, location-specific fine dust measurement is central for the assessment of urban air quality. Classic measurement approaches require dedicated hardware, of which professional equipment is still prohibitively expensive (>10k$) for dense measurements, and inexpensive sensors do not meet accuracy demands. As a step towards filling this gap, we propose FeinPhone, a phone-based fine dust measurement system that uses camera and flashlight functions that are readily available on today’s off-the-shelf smart phones. We introduce a cost-effective passive hardware add-on together with a novel counting approach based on light-scattering particle sensors. Since our approach features a 2D sensor (the camera) instead of a single photodiode, we can employ it to capture the scatter traces from individual particles rather than just retaining a light intensity sum signal as in simple photometers. This is a more direct way of assessing the particle count, it is robust against side effects, e.g., from camera image compression, and enables gaining information on the size spectrum of the particles. Our proof-of-concept evaluation comparing several FeinPhone sensors with data from a high-quality APS/SMPS (Aerodynamic Particle Sizer/Scanning Mobility Particle Sizer) reference device at the World Calibration Center for Aerosol Physics shows that the collected data shows excellent correlation with the inhalable coarse fraction of fine dust particles (r > 0.9) and can successfully capture its levels under realistic conditions.
A Multi-Objective INLP Model of Sustainable Resource Allocation for Long-Range Maritime Search and Rescue
Authors: Guo Yu , Ye Yanqing , Yang Qingqing , Yang Kewei
Published: February 2019

Maritime search and rescue (SAR) operations play a crucial role in reducing fatalities and mitigating human suffering. Compared to short-range maritime SAR, long-range maritime SAR (LRMSAR) is more challenging due to the far distance from the shore, changeful weather, and less available resources. Such an operation put high requirements on decision makers to timely assign multiple resources, such as aircraft and vessels to deal with the emergency. However, most current researches pay attention to assign only one kind of resource, while practically, multiple resources are necessary for LRMSAR. Thus, a method is proposed to provide support for decision makers to allocate multiple resources in dealing with LRMSAR problem; to ensure the sustainable use of resources. First, by analyzing the factors involved in the whole process, we formulated the problem as a multi-objective optimization problem, the objective of which was to maximize both the probability of completing the tasks and the utilities of allocated resources. Based on the theory of search, an integer nonlinear programming (INLP) model was built for different tasks. Second, in order to solve the non-deterministic polynomial-time hardness (NP-hard) model, by constructing a rule base, candidate solutions can be found to improve the calculation efficiency. Furthermore, in order to obtain the optimal scheme, the Non-dominated Sorting Genetic Algorithm II (NSGA-II) was applied to the candidate solution sets to approximate Pareto fronts. Finally, an emergency case of Chinese Bohai Sea was used to demonstrate the effectiveness of the proposed model. In the study, 11 resource allocation schemes were obtained to respond to the emergency, and calculation processes of schemes were further analyzed to demonstrate our model’s rationality. Results showed that the proposed models provide decision-makers with scientific decision support on different emergency tasks.
Study on Urban Expansion Using the Spatial and Temporal Dynamic Changes in the Impervious Surface in Nanjing
Authors: Qian Yanping , Wu Zhen
Published: February 2019

Impervious surface area is a key factor affecting urbanization and urban environmental quality. It is of great significance to analysis timely and accurately the dynamic changes of impervious surface for urban development planning. In this study, we use a comprehensive method to extract the time series data on the impervious surface area (ISA) from the multi-temporal Landsat remote sensing images with a high overall accuracy of 90%. The processes and mechanisms of urban expansion at different political administration and direction level in the Nanjing metropolitan area are investigated by using the comprehensive classification method consisting of minimum noise fraction, linear spectral mixture analysis, spectral index, and decision tree classifiers. The expansion of Nanjing is examined by using various ISA indexes and concentric regression analyses. Results indicate that the overall classification accuracy of ISA is higher than 90%. The ISA in Nanjing has dramatically increased in the past three decades from 427.36 km2 to 1780.21 km2 and with a high expansion rate of 0.48 from 2000 to 2005. The city sprawls from monocentric to urban core with multiple subcenters in a concentric structure, and the geometric gravity center of construction land moves southward annually. The stages of urbanization in different district levels and the dynamic changes in different direction levels are influenced by the topographic and economic factors.
Feasibility Analysis of Interleukin-13 as a Target for a Therapeutic Vaccine
Authors: Foerster John , Molęda Aleksandra
Published: February 2019

Background: The development of therapeutic vaccines requires thorough knowledge of potential hazards associated with long-term inactivation of self-proteins. Among potential targets, interleukin 13 (IL-13) merits consideration, as monoclonal antibodies disrupting IL-13 signaling are proving to be exceedingly effective in common conditions such as atopic dermatitis. Objective: Given the mass publication of scientific data, an appraisal of safety aspects is challenging. Methods: We here provide a three-fold approach to survey clinically relevant information on off-target effects, both adverse and beneficial, that may potentially be encountered in patients undergoing long-term IL-13 inactivation. First, we review non-clinical data in vivo and in vitro. Second, we summarize safety data accumulating from patients dosed with anti-IL-13 drugs. Third, we exploit human mutation data as well as emerging large-scale genetic datasets (global exome data from 60,000 patients) to obtain information on any association of IL-13-inactivating genetic variants with disease states. In addition, we: (1) dissect the precise efficacy signals obtained with various drugs targeting IL-13 and/or IL-4, and (2) summarize unintended, but potentially beneficial effects of prolonged IL-13 inactivation on several functional systems. Results: Prolonged repression of IL-13 in several thousand patients so far has not uncovered any non-redundant functions of IL-13 in immune defense. Furthermore, missense mutations in the key genes IL-13, IL-13Rα1, IL-13Rα2, IL-4, IL-4Rα are common, while no case reports have been published on any immune deficiency or increased risk of neoplastic disease associated with such mutations, suggesting that these genes do not harbor non-redundant roles in adult outbred humans. In terms of efficacy, data from clinically used drugs strongly suggest that targeting IL-13 only, as opposed to IL-13 and IL-4, may be effective in eczema while being more selective. Importantly, several lines of evidence suggest that inhibition of IL-13 may in fact harbor potentially beneficial effects on non-targeted systems, including glucose metabolism, hepatic fibrosis, and atherosclerosis, suggesting that respective outcomes should be systematically captured in patients dosed with IL-13 interfering drugs. Collectively, available evidence suggests that IL-13 may fulfill safety requirements required for the target of a therapeutic vaccine.
A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma
Authors: Almela Ramón M. , Ansón Agustina
Published: February 2019

In dogs, melanomas are relatively common tumors and the most common form of oral malignancy. Biological behavior is highly variable, usually aggressive, and frequently metastatic, with reported survival times of three months for oral or mucosal melanomas in advanced disease stages. Classical clinical management remains challenging; thus, novel and more efficacious treatment strategies are needed. Evidence-based medicine supports the role of the immune system to treat neoplastic diseases. Besides, immunotherapy offers the possibility of a precise medicinal approach to treat cancer. In recent years, multiple immunotherapeutic strategies have been developed, and are now recognized as a pillar of treatment. In addition, dogs represent a good model for translational medicine purposes. This review will cover the most relevant immunotherapeutic strategies for the treatment of canine malignant melanoma, divided among five different categories, namely, monoclonal antibodies, nonspecific immunotherapy activated by bacteria, vaccines, gene therapy, and lymphokine-activated killer cell therapy.
The Optimum Monitoring Location of Pressure in Water Distribution System
Authors: Jun Sanghyun , Kwon Hyuk Jae
Published: February 2019

This study proposes two methods for the determination of optimum monitoring locations of pressure changes in a water distribution system. A sensitivity analysis method is used to calculate the pressure change in a junction due to the change in demand at other junctions. A pressure contribution analysis method is used to calculate the summation of pressure contribution of a junction due to the change in demand at another junction. These methods are applied to a small sample pipe network, pilot plant, and small distribution system for verification. Furthermore, unsteady analysis of the sample pipe network and an experiment in the pilot plant are conducted to verify the availability and accuracy of the proposed methods. To verify the methods, leakage at J-55 was artificially produced at the pilot plant. The pressure change was measured at five different combination groups of sensor locations. From the results, it was found that the top ranked group of sensor locations, J-116, J-140, J-22, and J-68, had the highest pressure contributions and sensitivity. The results of the newly developed methods for the determination of monitoring locations are in good agreement with the results of the unsteady analysis. Finally, the proposed methods are applied to a real distribution system of a small city as a test bed. It is found that the proposed methods for determining the monitoring locations of pressure changes in the water distribution system are useful and effective.
Ultraviolet patterns of flowers revealed in polymer replica – caused by surface architecture
Authors: Schulte Anna J , Mail Matthias , Hahn Lisa A , Barthlott Wilhelm
Published: February 2019

Angiosperms and their pollinators are adapted in a close co-evolution. For both the plants and pollinators, the functioning of the visual signaling system is highly relevant for survival. As the frequency range of visual perception in many insects extends into the ultraviolet (UV) region, UV-patterns of plants play an important role in the flower–pollinator interaction. It is well known that many flowers contain UV-absorbing pigments in their petal cells, which are localized in vacuoles. However, the contribution of the petal surface microarchitecture to UV-reflection remains uncertain. The correlation between the surface structure and its reflective properties is also relevant for biomimetic applications, for example, in the field of photovoltaics. Based on previous work, we selected three model species with distinct UV-patterns to explore the possible contribution of the surface architecture to the UV-signaling. Using a replication technique, we transferred the petal surface structure onto a transparent polymer. Upon illumination with UV-light, we observed structural-based patterns in the replicas that were surprisingly comparable to those of the original petals. For the first time, this experiment has shown that the parameters of the surface structure lead to an enhancement in the amount of absorbed UV-radiation. Spectrophotometric measurements revealed up to 50% less reflection in the UV-absorbing regions than in the UV-reflecting areas. A comparative characterization of the micromorphology of the UV-reflecting and UV-absorbing areas showed that, in principle, a hierarchical surface structure results in more absorption. Therefore, the results of our experiments demonstrate the structural-based amplification of UV-reflection and provide a starting point for the design of bioinspired antireflective and respectively strongly absorbing surfaces.
Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives
Authors: Makarov Mikhail V , Migaud Marie E
Published: February 2019

The β-anomeric form of nicotinamide riboside (NR+) is a precursor for nicotinamide adenine dinucleotide (NAD+), a redox cofactor playing a critical role in cell metabolism. Recently, it has been demonstrated that its chloride salt (NR+Cl−) has beneficial effects, and now NR+Cl− is available as a dietary supplement. Syntheses and studies of analogues and derivatives of NR+ are of high importance to unravel the role of NR+ in biochemical processes in living cells and to elaborate the next generation of NR+ derivatives and conjugates with the view of developing novel drug and food supplement candidates. This review provides an overview of the synthetic approaches, the chemical properties, and the structural and functional modifications which have been undertaken on the nicotinoyl riboside scaffold.
MODELLING MAINTENANCE COSTS OF BUILDINGS UNDER WARRANTY
Authors: Ginevičius Romualdas , Andruškevičius Algirdas
Published: February 2019

An essential link in building construction is maintenance under warranty. It is hardly possible to predict now how the cost and time of building construction will affect maintenance costs and alternations during this period.

A correlation regression analysis has shown that the higher is the cost of the project, the higher the expenses, while the longer the time of the contract, the lower the costs. The total effect of the size and time of the project on the maintenance costs is positive implying that the higher they are, the greater are the expenses.

Expenses under warranty spread parabolically, i. e. they are the highest at the beginning and at the end of the considered period and the lowest in the middle of the time.

The cost and duration of a building contract has no direct impact on the distribution of building maintenance costs during the period under warranty.
VERBAL DECISION MAKING ANALYSIS
Authors: Kochin Dmitry , Ustinovičius Leonas
Published: February 2019

The paper presents the ideology of a qualitative approach to decision making ‐ verbal decision analysis. The authors have analyzed existing quantitative approaches and pointed out their main disadvantages. They formulated the requirements for decision‐making methods taking into account these disadvantages: psychological correctness of a dialog with decision maker (DM), strict mathematical proof of the methods and checking of DM information for consistency. The authors present the results of research on psychological correctness of operations of preference elicitation from DM. Several existing verbal decision analysis methods are briefly mentioned.
QUANTITATIVE EVALUATION OF TECHNOLOGY USED BY CONSTRUCTION ENTERPRISES
Authors: Ginevičius Romualdas , Andruškevičius Algirdas
Published: February 2019

Methods of quantitative evaluation of construction technology focussing on two major aspects of the production program of a construction enterprise are suggested. The above methods may be applied in quantitative and qualitative analysis of technology used in construction systems of buildings and structures. The quantitative analysis aims to evaluate the uniformity of the applied methods expressed by two indices ‐ an extent of size variation of building systems and their number. The qualitative aspect reflects technological solutions of building systems contained in the production programme of an enterprise.

The quantitative aspect of the applied technologies may be described in terms of size dispersion of the applied building systems.

A qualitative aspect of technology concerns the extent of building systems usage and the efficiency of technological solutions. The value of the first index may be obtained from the construction program of the construction enterprise, while that of the second may be determined by expert systems.

The calculations of a typical case confirm the efficiency of the suggested approach.
EXPERT AND KNOWLEDGE SYSTEMS AND DATABASES OF THE BEST PRACTICE
Authors: Kaklauskas Artūras , Zavadskas Edmundas Kazimieras , Gargasaite Leonarda
Published: February 2019

Investigations on the similarities and differences of expert, knowledge management and decision support systems are presented in the paper. Explicit and tacit knowledge is analysed. The benefit of knowledge management systems, their development and implementation are analysed. The aspects of the best practice and its knowledge bases and databases are described. Practical possibilities to apply the knowledge systems are presented. On the base of practice acquired during the FP 6 project INTELCITIES the database of the best practice and the web‐based decision support system for real estate are developed. On the base of the BPJTA in PuBs project the database of the best practice and the web‐based decision support system for retrofit of public buildings are developed.
THE RISKS AND LIABILITY OF PARTICIPANTS OF A CONSTRUCTION PROCESS FOR DEFECTS OF BUILDING PRODUCTS
Authors: Mitkus Sigitas
Published: February 2019

Sharing of the risk and liability is one of the most important functions of construction contracts. Proper sharing of the risks and liability between the parties of construction contract has a rather big influence on efficiency, quality, and probability of arising disputes between the parties of construction contract in construction projects.

A lot of risk exists during the fulfillment of construction projects. One of those risks is the risk of defects of building products. The question of the liability of the parties of construction contract for inappropriate quality of the construction production caused by a bad quality of building products mainly depends on sharing of the risk of defects of building materials in the construction contract.

Some aspects of the mentioned risk and liability of the parties of the construction contract might be set by mutual agreement in the construction contract. The other aspects are regulated by imperative norms of the law and the parties of construction contract have not a right to change those imperative conditions of sharing of risks and liability.

The article deals with sharing of risk and liability for supplying building products of an improper quality for construction, taking in to account conditions of construction contract, legal regulation and behavior of parties of a construction contract. A tree of forming the alternatives of liability is presented in the article.

Liability for supply of defected building products arises not only for parties of a construction contract. The producer (supplier) of building products is responsible for this as well. Variations of liability of the producer (supplier) depending on construction contract conditions are analyzed. A matrix of liability of the producer (supplier) of building products is presented in the article.