bluuebunny/crossref_metadata_2025 huggingface dataset:
Postovariectomic syndrome is the predictor of osteoporosis development
Authors: Pokul L. V. , Yevtushenko I. D. , Ivanova T. V.
Published: June 2020

In this article clinical indexes of the dynamics of mineral bone density according to both densitometry and marker of resorption as well as bone formation and steroid blood hormons in patients in postovariectomy are analysed. These patients state was complicated by cancer of the corpus and colli uterus after etiopathogenetic treatment including total husterectomy, radiation therapy and polychemotherapy. According the results of the comparative analysis in patients with postvariectomic syndrome developed after surgical treatment for benign internal genitalia diseases we may make the conclusion on pathogenetic role of postovariectomic syndrome in the development of bone disturbances in female patients which underwent total hysterectomy and special therapy.
Assessment of the relation of doctors and patients to development of business in medicine
Authors: Rabtsun Ye. A.
Published: June 2020

The opinion of doctors and patients on the suitability and forms of business activity in medicine is studied. For most people, free medical aid has not clear boundaries, and this fact significantly reduces the motivation to payment for medical services, that is, restrains the demand. The businessmen’s mentality is not formed as well: in the medical community, a medical service is not realized as a good, and the medical activity is not understood as an activity on production and marketing of medical services, the «kept» psychology dominates. The paying capacity of people should not be considered as a key factor restraining the development of medical business. The more significant problem is that the current medical system is not ready and capable to sell medical services to people having the considerably increased level of consumer demand.
Physiological basis for provision of power abilities in weightlifters and martial artists
Authors: Gurova M. V. , Kapilevich L. V.
Published: June 2020

The bioelectric activity of muscles in weightlifters and martial artists of different qualification has been assessed comparatively. With a specialized load, the synchronization of the electric activity of skeletal muscles was observed in highly qualified martial artists, while in weightlifters the efficiency of motions increased. The revealed physiological peculiarities of provision for power abilities can serve as objective indicators for on-line control over the process of power training of sportsmen of different specializations.
Change in local regulation of hemopoiesis under the chronic exposure to ionizing radiation
Authors: Porovsky Ya. V.
Published: June 2020

Results of annual examinations of peripheral blood and single examinations of bone marrow after 11, 14, 15, and 22 years of the chronic exposure to ionizing radiation in total doses of 24.25, 103.96, 111.84, and 74.09 mSv, respectively, are presented along with the results on the morphology of microvasculature vessels in skin tissue samples of two men and two women working at a nuclear reactor. Changes in the content of hemoglobin, total number of leucocytes, population of erythrocytes, neutrophils, reticulocytes, and in the composition of maturating and mature myeloid and erythroid cells accompanied by an increase составе in the number of cells of the lymphoid and monocytic pool as the intensity of inflammatory changes in microvasculature vessels increases from productive panvasculitis to panvasculitis with sclerosis of vessel wall were noticed. The presented actual material indicates that damages in the blood system can be connected with the intensity of pathological changes in microvasculature vessels, which represent one of the local components of hemopoiesis-inducing microenvironment responsible for hemopoiesis regulation.
Cytotoxic activity of peripheral blood lymphocytes in children with infectious mononucleosis
Authors: Slepicheva N. R. , Urazova O. I. , Novitsky V. V. , Pomogayeva A. P.
Published: June 2020

Twenty children aged 3—6 years with Epstein—Barr-virus-induced infectious mononucleosis (IM) were examined. The present study is aimed at investigating the functional activity of cytotoxic lymphocytes in children with IM during clinical and hematological manifestation of the disease and early reconvalescence phase. For analyzing the subpopulation composition of peripheral blood lymphocytes in children with IM the CD-receptors on cell surfaces (CD8, CD16) were defined; for estimating apoptosis the amount of CD95-, CD95L- and annexin V-positive lymph cells (immunofluorescence method) was assessed. For determination of TNFα concentration in cultural supernatants the solid-phase immunoenzyme method was applied. It was defined that clinical and hematological manifestation of IM is accompanied by increase in the amount of CD8-, CD16-lymphocytes in blood and activation of Fas-dependent apoptosis of lymphocytes that is preserved in early reconvalescence period. Here limitation of lymphocytic cytotoxicity results from a decrease in TNFα secretion.
For history guestion about sciencific schools
Authors: Fyodorova G. V. , Scherbakov D. V.
Published: June 2020

In history study, as a rule, happens to give the estimation to activity that or other scientist, quite often integer of the group, defining their role in formation and development of medicine of the region in determined chronical frame. However hitherto no united opinion for importances «scientific school». In work is made attempt of the analysis existing opinions on this subject, their collations and comparisons for the reason separations the most exhausting.
Comparative epidemiological characteristics of bronchial asthma according to data of International Study of Asthma and Allergy in Childhood (ISAAC)
Authors: Kamaltynova Ye. M. , Deyev I. A. , Belonogova Ye. G.
Published: June 2020

The review includes information about the asthma epidemiology among childhood and methods of researches. The data investigation project International Study of Asthma and Allergy in Childhood — ISAAC showed the asthma and allergic diseases in Word. The ISAAC results (Phase One and Phase Three) were revealing the differences in the prevalence of symptoms of asthma between the countries.
Public agreement in the rendering of paid medical services to people
Authors: Rabtsun Ye. A.
Published: June 2020

The position that the agreement on the rendering of paid medical services to people (physical persons) is a public agreement is justified. The public agreement differs in its legal order of performance from the ordinary agreement on the paid rendering of (medical) services. The writing form and handling procedures of this agreement are also different.
Implanted electrhydraulic artificial heart
Authors: Shubladze A. M. , Baikov A. N. , Shvaryova N. A. , Tolpekin V. Ye.
Published: June 2020

The problem of full-featured, high-efficiency replacement of the heart’s pumping ability with an artificial analog is urgent all over the world. The most promising model of an implanted artificial heart is now the model with the elecrohydraulic principle of operation. In the weight and overall dimensions and in the efficiency, this model can compete with the most popular Abiokor model of the artificial heart.
Game-based biofeedback in the adaptation of junior schoolchildren
Authors: Danilenko Ye. N. , Jafarova O. A. , Grebneva O. L.
Published: June 2020

The paper presents the results of the use of the computer game-based biofeedback in the process of adaptation to the school learning. We conducted health-improving development lessons in several groups of junior schoolchildren. Analysis of the results showed high efficiency of the use of computer biofeedback at school. 3 types of children’s behavior during the lessons were described; one of them might be related to the risk group of ADHD syndrome.
The relation between the individual mechanisms of self-regulation and stress-resistance
Authors: Shcheblanov V. Yu. , Bobrov A. F. , Jafarova O. A. , Nadorov S. A.
Published: June 2020

In this paper we described psycho-physiological characteristics of the groups with different extent of the intensity of selfregulation skills under stress modelled by game biofeedback technology. We compared them with the stress-resistance evaluation from the model of operators' performance under conditions of limited time. The relation between the effectiveness of the performance during game biofeedback and stress resistance was shown. The new method of the evaluation of this key characteristic of hazardous occupation was suggested.
EEG alpha-activity in neurotherapy of attention deficit syndrome using game biofeedback
Authors: Stoller I. A. , Sukholentseva M. V. , Tkachenko N. N. , Veryovkin Ye. G. , Shtark M. B. , Yarosh S. V.
Published: June 2020

The dynamics of the segment characteristics of alpha-rhythm and their correlation with the «behaviour» of dipole sources of alpha-band in relation to beta-stimulating neurofeedback in schoolchildren with ADHD syndrome were analyzed. Effective training results in forming of neuronal groups in alpha-band which correlate to the new dipole sources. Possible place of alpha-generating system in the mechanisms of effective neurobiofeedback is discussed.
Efficiency of combination of physio- and reflexotherapy methods and technology of biofeedback in correction of psychovegetative disoders
Authors: Polyakova A. G. , Matveeva V. V.
Published: June 2020

There was a clinical efficiency analysis with combination of physio and reflexotherapy methods and apparatus biocontrol in a complex approach of recover correction of vegetative disfunctions among military people at the age from 22 to 55. Control of apparatus biocontrol course efficiency followed on dynamic of clinical symptoms, electrocardiogram indexes, general and biochemical blood analysis, reflex diagnostics data according to the methodic of vegetative resonant testing and questionnaires characterizing condition of psycho emotional sphere (SAN, test of Spilberg—Khanin).

There was a determination of general non specific adaptation reaction with using Garkavi—Kvakina—Ukolova index. Rehabilitation results of the patients who got BOS therapy proved its efficiency.
Psychophysiological reactions analysis at stress-testing of the military universities cadets
Authors: Tishakin D. I. , Jafarova O. A. , Grebneva O. L.
Published: June 2020

The purpose of this study — to explore psychophysiological mechanisms to respond in a stressful situation. We used the methods of psycho-diagnostics, and specially designed protocols psychophysiological testing. The study was conducted on a group of cadets of the military university, candidates for the combined team on the tactical and technical decathlon. The study identified prognostic group of successful and unsuccessful athletes and describes the characteristic for each group of physiological patterns.
The dynamic of brain rhythms after neurofeedback course
Authors: Kaigorodceva O. V. , Tristan V. G. , Talamova I. G.
Published: June 2020

In this article there is comparative analysis of cerebrum biopotentials of sportsmen in different periods after the end of neurofeedback course. It was revealed the character of late effects has depended on success of the training and period it’s end. For sportsmen studying increase the alpha-rhythm power arbitrarily it is typical: the alpha-rhythm power of both hemispheres increased strait a way after training with closed eyes and during 3 months with opened eyes which in a year was being slow decreased. The values of β- and θ-rhythms were slow decreased in 6—12 months. For sportsmen how were held training unsuccessfully it is typical increasing of alpha-rhythm power in a year, which didn’t depend on decreasing of visual afferentation. The changings of θ-rhythm had wavy character, the β-rhythm power was being decreased.
The importance of respiration biomechanics and high resolution computed tomography for bronchial-obstructive syndrome diagnostics
Authors: Ekkardt E. V.
Published: June 2020

The aim of our research was analysis and comparison of chronic obstructive lung disease clinicalsigns and function indices of external respiration apparatus and inspiratory-expiratory high resolution computed tomography. 48 patients with chronic obstructive lung disease were examined. The importance of respiration biomechanics and inspiratory-expiratory high resolution computed tomography indices for diagnostics of broncho-obstruction at an early stage with unchanged forced expiration volume within the first second was revealed.
Opportunities of modern methods of radiodiagnosis for psoriatic arthritis
Authors: Klimentenko N. L. , Pesterev P. N. , Perova T. B. , Zaviуalova N. G. , Zhogina T. V. , Usova N. H. , Okuneva L. I.
Published: June 2020

The comparative evaluation of modern imaging methods gives evidence of great opportunities of both MRT and US in the detection of structural alterations of joints at psoriatic arthritis. The key role is assigned to ultrasonography which has proved to be highly sensitive in the disclosure of peripheral joint synovitis and allows the follow-up during the treatment course.
Probability forecasting of a syndrome of multiorgans insufficiency development in patients with a peritonitis
Authors: Alekseyev D. V. , Shipakov V. Ye.
Published: June 2020

A investigation of the indices, characterizing a functional condition of the hemostasis in patients with peritonitis, to takes more reliable trend forecasting a development of the multiorgans insufficiency syndrome and unfavorable outcome of the disease, tran research of hemodynamic and autointoxication states.
Features of the immune disbalance during various clinico-pathogenetic variants of acute progressive pulmonary tuberculosis
Authors: Voronkova O. V. , Urazova O. I. , Novitsky V. V. , Churina Ye. G. , Khasanova R. R. , Naslednikova I. O. , Filinyuk O. V. , Serebryakova V. A. , Kolobovnikova Yu. V. , Nikulina Ye. L. , Pirogova N. P. , Berezko I. V.
Published: June 2020

In article the data, concerning features of cellular composition, proliferative activity and cytokines production of peripheral blood lymphocytes is presented in patients with various clinico-pathogenetic variants of pulmonary tuberculosis: drag-sensitive and drug-resistant infiltrative, disseminated, fibrous-cavernous. It is established that the extensive destructive tuberculosis without dependence from the clinical form of disease is accompanied by the expressed insufficiency of the cellular-mediated mechanisms of immunological resistance both to drag-sensitive, and to drug-resistant M. tuberculosis against quantitative prevalence of B-lymphocytes and intensity of their functional activity.
A investigation of the influence of water-soluble polysaccharides of calamus root (Acorus calamus L.) introduction on the functions of experimental animals (pathomorphological aspects)
Authors: Guriyev A. M. , Belousov M. V. , Akhmedzhanov R. R. , Yusubov M. S. , Churin A. A. , Fomina T. I. , Karpova G. V.
Published: June 2020

The influence of the sum of water-soluble polysaccharides (WSPSs) extracted from sedge (Acorus calamus L.) rhizomes on the state of internal organs of rats and rabbits at a long parenteral administration has been studied. The intraperitoneal WSPS introduction to rats in doses of 20, 100, and 200 mg/kg of body mass for 3 months and the intravenous WSPS introduction to rabbits in doses of 25 and 50 mg/kg of body mass for 1 months caused no pathological changes in the morphology of internal organs and systems.
State of glucocorticoid function and its regulation in patients with laryngeal cancer depending on the stage of the disease
Authors: Kalyi V. V. , Chertova N. A.
Published: June 2020

Glucocorticoid supply of the organism of patients with laryngeal cancer at different stages of malignant process has been studied. Formation and development of laryngeal cancer is accompanied by hormone-metabolic disturbances of hypophysis-adrenalocortical system, their character and degree of development being determined to a large extent by the stage of malignant process.
Vegetative provision of the cardio-vascular system while orthostatic sportsmen testing
Authors: Kudrya O. N.
Published: June 2020

The article includes the results of the researching vegetative provision of the cardio-vascular system activity of 314 sportsmen 9—25 years old in patience and while orthostatic testing. It was discovered that in different age periods the process of urgent the cardio-vascular system adaptation while orthostatic testing is connected with different controlling levels cardio rhythm activating.
Opistorchis felineus invasion influence on immunity in bronchial asthma
Authors: Ogorodova L. M. , Freidin M. B. , Sazonov A. E. , Fyodorova O. S. , Deyev I. A. , Kremer Ye. E.
Published: June 2020

To investigate the molecular mechanisms of human immune response modification by Opisthorchis felineus antigens in bronchial asthma. The experimental study was performed with cell cultures from patients with bronchial asthma, patients with opisthorchiasis, and patients with BA and opisthorchiasis co-occurred. A proposed down-regulation of immune response by higher level of IL10 and TGFB genes expression in patients with opisthorchiasis was revealed.
Contributing factors to primary headaches chronicity
Authors: Karpova M. I. , Shamurov Yu. S. , Zuyeva A. V.
Published: June 2020

Comparison of episodic and chronic forms of primary headaches to reveal the possible factors leading to the disease chronicity has been performed. Some of the comorbidities were considered to be the conditions resulting in a more severe course of migraine and headaches of tension. Significant prevalence of clinical manifestations of immune system impairment in patients with chronic cephalgia was noted. It was suggested that the above impairment might be one of the factors accounting for the transformation of course of primary headaches.
Clinical and elektroneuromyographycal characteristic of traumatic brachial plexopathy
Authors: Afina E. T. , Nadezhdina M. V. , Soroka A. V. , Mityashina M. V.
Published: June 2020

53 patients with traumatic brachial plexopathy were exsamined during the clinical and elektroneuromyographycal study. It was determined that the structure of traumatic brachial plexopathy had 5 types of injury: upper Erbs palsy (С5—С6) (28,3%), lower Klumpcs palsy (С8—Th1) (15,1%), whole palsy (С5—Th1) (18,9%) and 2 groups of combined plexopathies with paralyses of flexible muscles of upper arm and fingers (С5—С7) (16,9%) and paralyses of extensible muscles of forearm and hand (С6—С8) (20,8%). 3 variants of disturbanses of nerve fibres were found during the experiment. They were axonal variant for whole palsy, Erbs palsy and injury of motor fibres for Klumpcs palsy. Combined type of injury was characterized for whole palsy, extensible paralyses (С6—С8) and injury of sensory fibres for Klumpcs palsy. Demyelinizationary type of injury was characterized for combined flexible paralyses (С5—С7).
Carbohydrate metabolism in cerebral stroke patients
Authors: Volchenkova T. V. , Kolchu I. G. , Isakova Ye. V. , Kotov S. V.
Published: June 2020

Early carbohydrate disturbances (ECD) influence cerebral stroke development and course. Prevalence and co-morbidity of different carbohydrate metabolism types were studied in 107 cerebral stroke patients. It was determined that different disturbances developed in 70% of cerebral stroke patients. Even ECD negatively affected cerebral stroke course.
Changes neuron-specific enolase and protein S100 in the acute period of tick-borne infections in children
Authors: Galiyeva G. Yu. , Poponnikova T. V. , Bedareva T. Yu.
Published: June 2020

We evaluated clinical and laboratory findings in 86 patients of 4—16 years old. Data showed that in all forms of tick-borne infections S100 concentration increased. In meningeal forms of tick-borne infections the S100 level was highest in cases of prolonged progression. The results let conclude that increasing of S100 concentration in all clinical forms of tick-borne infections reflexes the severity of CNS disturbances and their correlation with clinical manifestations.
Heart rate variability with orhtoclinostatic load in patients with neuroreflex syncopal states
Authors: Grebenyuk O. V. , Katayeva N. G. , Novikova N. S. , Svetlic M. V.
Published: June 2020

The initial vegetative tonus and vegetative reactivity were studied in patients with neuroreflectory syncopal states (NSS) during passive orthostatic testing in the orthostatic and clinical phases. The variability of the heart rhythm was estimated on the Neiron-spektr device. During the orthostatic testing, the insufficient activity of the sympathetic part of the nervous system in NSS patients was observed compared to the control group. During the clinostatic testing, the indices of NSS patients approached the normal values.
Tick-borne encephalitis: immunological indicators of possible transformation of acute process into chronic disease
Authors: Gusev Ye. I. , Parkhomenko T. A. , Buneva V. N. , Doronina O. B. , Doronin V. B. , Generalov I. I. , Doronin B. M. , Nevinsky G. A.
Published: June 2020

Several autoimmune diseases with chronic clinical course are characterized by detection of DNA autoantibodies in patients’ serum, while there are no such IgGs in healthy donors’ blood or in patients with acute clinical course with no evidence of chronization. Tick-borne encephalitis has not been considered this way. Several strict criteria have been applied to show that the DNase activity is an intrinsic property of IgGs from the sera of TBE patients but not from healthy donors. The relative activity of IgGs has been shown to vary extensively from patient to patient, but most of the preparations (91%) had detectable levels of the DNase activity. Polyclonal DNase IgGs were not active in the presence of EDTA or after a dialysis against EDTA, but could be activated by several externally added metal ions, with the level of activity decreasing in the order Mn2+ + Ca2+ ≥ Mn2+ + Mg2+ ≥ Mn2+ ≥ ≥ Mg2+ + Ca2+ ≥ Ca2+ ≥ Mg2+ > Ca2+, while K+ , Na+ , Ni2+, Zn2+, and Cu2+ did not stimulate DNA hydrolysis. Affinity chromatography on DNA-cellulose separated the DNase IgGs into many subfractions with various affinities for DNA and very different levels of the relative activity. Possible reasons for catalytic diversity of polyclonal human Abzs are discussed.
Emphysema diagnostics in patients with chronic obstructive lung disease
Authors: Ekkardt E. V. , Bodrova T. N. , Tetenev F. F. , Rodionova O. V.
Published: June 2020

The aim of the research was comparison of clinical symptoms, respiration biomechanics indices of patients with chronic obstructive lung disease. It was revealed that respiration biomechanics indices are the earliest emphysema signs of patients with chronic obstructive lung disease in the period when the structure of total lung capacity is not changed.
A case of massive opisthorchosis invasion of pancreatic ducts
Authors: Merzlikin N. V. , Paramonova L. M. , Klinovitsky I. Yu. , Erendeyeva L. E. , Lyzko I. A.
Published: June 2020

The objective of the present publication is to show clinical case of a rare massive affection of pancreatic duct by opisthorchosis.
Ultrasonic and scintigraphic monitoring of thyroid residue after operation of various volume on thyroid gland
Authors: Gasparyan S. N. , Popov O. S. , Zavadovskaya V. D. , Perova T. B. , Tikhonov V. I. , Kilina O. Yu.
Published: June 2020

The 105 patients were undergone the medical observation after operations of various volume on thyroid gland. The patients were divided into 3 groups — patients without additional changes (n = 74), with nodes in residual tissue (n = 20), patients with glandular tissue after thyreoidectomy (n = 11). The amount of relapses was increasing with prolongation of postoperative period. For specification of relapsing nodules and thyroid residue spreading after thyreoidectomy the complex radiological examination is proposed.
Peculiarities of blood supply of inferior angle of scapula from the system of thoracodorsal angiosom
Authors: Aksyonov A. A. , Sotnikov A. A. , Kalyanov Ye. V.
Published: June 2020

At the current stage of development of the reconstructive-plastic surgery, to remove combined soft-tissue—bone defects, a combined thoracodorsal flap is used most often. This flap includes, as a bone fragment, the lateral edge of scapula, which is supplied with blood by the arterial branch surrounding the scapula. However, our investigations of the blood supply of thoracodorsal flap from the system of thoracodorsal angiosom indicate that the inferior angle of scapula is supplied directly from the system of thoracodorsal artery. Based on the results obtained, we concluded that the inferior angle of scapula is supplied by the branch of the thoracodorsal artery, which has a length of (54.0 ± 11.8) mm and a diameter of (1.3 ± 0.3) mm and can be included in the combined thoracodorsal flap.
Molecular-genetic factors of a pulmonary tuberculosis
Authors: Urazova O. I.
Published: June 2020

The modulating influence of a causative agent on the character of an immune reaction at lung tuberculosis is analyzed. Peculiarities of immunopathological reactions depending on the etiological version of a disease and the spectrum of bacterial resistance to antituberculous preparations are discussed with the justification of possible approaches to their correction. Main fields of research activity at the Chair of Pathophysiology of the Siberian State Medical University (Tomsk) concerning immunopathology of the tuberculosis infection are presented.
New data about consistency of skin prick-tests results with specific immunoglobulin E level and food allergy symptoms in children of opisthorchiasis endemic areas
Authors: Ogorodova L. M. , Fyodorova O. S. , Deyev I. A.
Published: June 2020

Aim: to investigate the consistency of skin prick-tests results with specific IgE level and symptoms of food allergy. The criteria of food allergy in children of opisthorchiasis endemic areas were developed: symptoms of food allergy within 2 hours, skin pricktests weal size ≥1 mm and (or) specific IgE ≥0,35 kUA/l.
Role of IL6 –174C/G gene polymorphism in development of chronic HCV infection
Authors: Semyonova N. A. , Ryazantseva N. V. , Novitsky V. V. , Bychkov V. A. , Chechina O. Ye.
Published: June 2020

In the investigation it has been estimated the functional importance of gene interleukin 6 (IL6) polymorphism in progressing the chronic hepatitis C virus (HCV) infection. It has been determined the analysis of polymorphism –174 C/G frequency in gene IL6 promote zone at healthy donors and patients with chronic HCV-infection who are the Caucasian representatives of Tomsk region. The genotype GG carriers definitely dominated at patients with high activity rate of inflammatory process: it shows that G allele carriership have an impact on aggravation of inflammatory process activity in the liver patients with HCV-infections. In contrast to, carriership of C/G and C/C genotypes of polymorphism –174 C/G of gene IL6 have met more often at patients with minimal and moderate degree of inflammatory process.
Reception and medical and biologic tests marked by 99mTc norfloxacin of the hydrochloride
Authors: Varlamova N. V. , Scuridin V. S. , Sazonova S. I.
Published: June 2020

Are carried out researches on creation of a standard reagent for reception marked by 99mТс Norfloxacine hydrochloride. An estimation of influence of components of a reactionary mix on radiochemical cleanliness of a received preparation spent a method for thin-layer chromatographies. On experimental animal (rabbits) with model of an inflammation of various localization functional suitability marked by an antibiotic for diagnostics of inflammatory processes is shown.
The analysis of a diabetes mellitus of type 1 desease and prevalence among children and teenagers of Tomsk Region
Authors: Samoilova Yu. G. , Enert A. V.
Published: June 2020

The diabetes mellitus of 1 type (DM1) represents a huge problem all over the world. In spite of the fact that there is a plenty of the saved up knowledge on эпидемиологии and management of the given disease in the developed countries, there is a number of mistakes and the discrepancies supposed at creation of the Federal register of a diabetes that is connected with absence of completeness of scope of all regions. With the purpose of reception of the full information on prevalence and desease DM1 among children and teenagers, for duly maintenance sick DM1 necessary quantity of insulin and means of self-checking and as with the purpose of updating of data of the Federal register there was a necessity to estimate an epidemiological situation on DM1 among children and teenagers of Tomsk Region. The lead analysis has shown, that growth DM1 in all age groups and especially among children of younger age is marked.
25th Anniversary of the Chair of Restorative Medicine, Balneology, and Physiotherapy of the Department of Postgraduate Education of the Siberian State Medical University
Authors: Perminova N. M. , Nechayeva Ye. I.
Published: June 2020

The history of the Chair of Restorative Medicine, Balneology, and Physiotherapy, Department of Postgraduate Educ ation, Siberian State Medical University (Tomsk), is described, its founders are presented, and main aspects of its work are elucidated.
An investigation of the introduction of water-soluble polysaccharides calamus root (Acorus calamus L.) effect on the experimental animals functions
Authors: Gurieyv A. M. , Belousov M. V. , Akhmedzhanov R. R. , Yusubov M. S. , Churin A. A. , Karpova G. V.
Published: June 2020

An investigation has been performed as to the effect of a long-term parenteral introduction of the sum of water-soluble polysaccharides (WSPS) calamus root (Acorus calamus L.) extracted by means of the in-house technology on the functions of experimental animals. As it follows from the results of the experiments, the intragastric introduction of the WSPS to rats in the doses of 20, 100, and 200 mg/kg during a three-month term and the intravenous introduction to rabbits in the doses of 25 and 50 mg/kg during a one-month term do not lead to the death of the animals or to any pathological changes in their general condition, the dynamics of the general weight, or the functional activity of the investigated internal organs and systems.
Dynamics of respiratory system clinicofunctional scores among patients with COPD in the complex rehabilitation at the Health resort Belokurikha
Authors: Komissarov K. V. , Viktorova Ye. V. , Trubnikov G. V.
Published: June 2020

The aim of the study was to estimate the dynamics of respiratory system clinicofunctional scores among patients with COPD at the health resort Belokhuriha. There were examined 188 cases of mild and middle-severe COPD. All the patients received different rehabilitation complexes in the conditions of health resort Belokuriha’s climate-recreational zone against the background of which there was conducted an estimation of the respiratory system clinicofunctional scores and depending on the applied methods there was evaluated its efficiency. In the process of the group rehabilitation where physical exercises were included there was recorded the dynamics of the main symptoms — decrease of the manifestation degree of dyspnea, cough, sputum discharge and scores of the respiratory system functional tests. OFV1 has reliably increased only in the group where clipping massage, exercises in the counter-resistance mode for the respiratory muscles and the terrainkur were used. The use of physical exercises in the rehabilitation of patients with COPD improves clinicofunctional scores of the respiratory system and its efficiency.
Features of clinical-functional parameters of the heart, vessels and microcirculation in patients with arterial hypertension in the combination to chronic obstructive pulmonary diseases
Authors: Shpagin I. S. , Shabalin A. V. , Shpagina L. A. , Gerasimenko O. N. , Shlyakhtina N. V.
Published: June 2020

The clinical and functional status of the heart, peripheral vessels and microcirculation. The features of structural-functional state of the heart and peripheral vessels. Showing violations cardiohemodynamic and peripheral blood flow. Identified various pathological hemodynamic types. The worst-case remodeling and blood flow disturbances were detected in patients with arterial hypertension in combination to chronic obstructive diseases of lungs against pulmonary hypertensia.
Thyroid hormonal status dynamics as a preoperative preparation efficiency criterion of patients with thyreopathies
Authors: Galyan A. N. , Popov O. S. , Larionov M. M. , Lyan N. I. , Gasparyan S. N. , Geydarov R. E. , Galyan Ye. V. , Udut V. V.
Published: June 2020

On a thyroid disease conservative correction background, preoperative period is accompanied by the upcoming surgery risk and its optimal level assessment, as well as assessment of specific complications development possibilities. Typically, the thyreopathies pathogenesis is accompanied by the thyroid gland functional activity disorder, which provides variety and, in some cases, the clinical picture similarity. Also, due to metabolic processes endocrine regulation fail in the whole organism, it causes disorders development in various organs and systems. Each thyreopathy is characterized by the relevant homeostasis indicators and clinical finding, in the development of which, the role of thyroid gland hormone production variant (hypothyroidism, hyperthyroidism, euthyroidism) and the deviation intensity level are not significant only as a pathological process marker, but also determine the compensation of an adaptive disorder tactics in pre- and postoperative period.
Advantages of hybrid surgery using elastic stents of nikelid-titanium TН-10 in vascular surger
Authors: Frants V. V. , Ivchenko O. A. , Ivchenko A. O.
Published: June 2020

Study objective is clinical use of a stent of flat over-elastic element with the effect of elastic recovery — nikelid-titanium of TH-10 make in case of occlusive diseases of main arteries. Hybrid approach has been used, that is femoropopliteal shunting with stenting of deep artery of thigh with the construction of nikelid-titanium ТН-10. In pre-surgical and post-surgical periods malleolarbrachial index Charcot's syndrome, life quality of the sick Charcot's were studied. The used methods improves blood supply of a limb by 31 percent according to the clinical parameters, in comparison with the control set. In recent and distant post-surgical periods there was no complications found.
Effect of side effects antituberculosis preparations on upshots of the treatment patients with multidrug-resistant tuberculosis, who had received treatment on scheme of the program DOTS-PLUS
Authors: Schegertsov D. Yu. , Nekrasov Ye. V. , Yanova G. V. , Filinyuk O. V. , Buinova L. N. , Anastasov O. V. , Stepanova Ye. P. , Felker I. G.
Published: June 2020

At treatment of patients with multidrug-resistant tuberculosis of lungs on scheme of the program DOTS-PLUS was noted development that or other side reaction on the part of organs and systems. We studied temper, frequency of the development of side effect upon upshot of the treatment beside by 101 patients in process of stationary course of the treatment.
Application of wave-current sinusoscopy in algorithm of diagnostic and treatment of odontogenic maxillary sinusitis
Authors: Alexandrov A. A. , Starokha A. V. , Davydov A. V. , Votyakov V. F.
Published: June 2020

The aim and task of the study were to improve the method of wave-current sinusoscopy and to develop the algorithm of compex treatment of acute odontogenic maxillary sinusitis with concomitant pathology of intranasal structures abnormalities. 106 patients with acute and chronic odontogenic maxillary sinusitis were examined. The improved method of wave-current sinusoscopy allows with high level of significance to diagnose in the maxillary sinus not only exudates and side-wall hyperplasia, but artificial bodies — according to the value of wave-current sinusoscopy equal to (247 ± 74) Hz. Including this method to the treatmentdiagnostic algorithm helps to improve treatment of the patients with odontogenic maxillar sinusitis.
The effectiveness of medical care to patients with asthma in Tomsk Region
Authors: Kobyakova O. S. , Ogorodova L. M. , Abashina L. V. , Deyev I. A. , Starovoytova E. A.
Published: June 2020

A statistical study of indicators of primary and chronic morbidity, mortality, clinical examinations, emergency care, the level of hospitalization of patients with asthma in the Tomsk Region for the years 1998—2008 was performed. This study used data of 843 thousand inhabitants of the Tomsk Region in the age of 18 years.

During 1998—2008 in the Tomsk Region has made significant progress in the conduct of asthmatic patients, which is reflected in the cost of health care and higher quality care this patient.
Dynamics of somatogenic comorbid anxiety-depressive disorders expression under the tiotropium bromide treatment influence
Authors: Fedosenko S. V. , Kirillova N. A.
Published: June 2020

The aim of comparative research was the estimation of alarm and depression dynamics at patients with stable chronic obstructive pulmonary disease under influence of tiotropium treatment on HADS questionnaire. Are surveyed 30 patients who were not receiving supporting therapy and 27 patients, using a fluticasone/salmeterol combination. After 3 months of tiotropium treatment the level of alarm and depression decreased in both groups.
Value of diagnostic theory at studying of internal diseases on pediatric faculty
Authors: Tetenev F. F. , Bodrova T. N. , Kalinina O. V.
Published: June 2020

It is proved in the article to decide studying of bases of theory of diagnostic on pediatric faculty, that allow problem development and formation clinical thinking irrespective of quantity of hours of internal diseases released for teaching.
Assoclation polymorphism apoe gene and blood lipid profile with diffe different types of stroke in Siberia
Authors: Voevoda M. I. , Skurikhina Yu. V. , Shishkin S. V.
Published: June 2020

The present research aimed at studying association between Apo E polymorphism and certain types of stroke and also association factors of lipid profile’s results and different types of stroke it depends on sex and conditions of living in typical West Siberian megapolis (Novosibirsk).

The causes of brain stroke were registered in representative population with population about 150 000 in according to standarts of WHO program MONICA and previous program «Register of stroke». From 2003 to 2007 among new registered and repeated causes of stroke was form at random 15% sample (261 patients). The average age of stroke attack is 61,3 ± 1,0 for men and 61,3 ± 1,0 for women.

Independent influence of APOE gene's genotypes polymorphism on development at different stroke patients has not been revealed.
Life quality of patients in acute stage of traumatic brain injury for influence of neurothrofic therapy
Authors: Karakulova Yu. V. , Selyanina N. V. , Eroshina O. A.
Published: June 2020

The complex study of 63 patients was performed. It included 45 males and 18 females (the average age 31,5 ± ±13,3). All the patients had an acute stage of traumatic brain injury (TBI). The patients were divided into 3 groups. 27 patients had brain concussion, 12 and 24 patients suffered from mild and middle brain contusion. Emotional status study showed the increase of reactive anxiety. Life quality assessment showed a significant decrease in all of the questionnaire SF-36 scales. 15 brain contusion patients underwent neuroprotective therapy — they were given 10 intravenous injections of cerebrolysin within 10 days. All the patients showed less number of neurological symptoms, anxiety level and a significant quality of life improvement after the treatment. Thus, the acute stage of TBI is characterized by the quality of life and the adaptation capability decreasing. They are accompanied by the mild affective, emotional and autonomic impairment that demand neuroprotective treatment.
Immunal and biochemical indexes in early diagnostics of chronic brain ischemia
Authors: Nechunaeva Ye. V. , Shumakher G. I. , Vorobiyova Ye. N. , Timoshnikov A. V. , Khoreva M. A.
Published: June 2020

The paper presents results of clinical and laboratory investigation of 106 patients with chronic brain ischemia (CBI) I—II stages, included detection levels of circulating desquamated endothelial cells, endothelin-1, autoantibodies to encephalitogenic protein, neuron-specific enolase and protein S100. Reliable changes of immune status as well as signs of endothelium dysfunction progressed with stage of CBI. Direct correlation between intensity of endothelium dysfunction and activity of neurodegererative process in brain was revealed.
Neurospecific enolase as a nonspecific neurodegenerative process marker
Authors: Zhukova I. A. , Alifirova V. M. , Zhukova N. G.
Published: June 2020

For the diagnosis and prognosis of various diseases is essential to determine specific markers in blood serum. Neuronspecific enolase (NSE) is a common marker of differentiatedneurons. The aim of the study was to evaluate the activity of NSE in patients with Parkinson's disease (PD) and chronic cerebral ischemia. The study results showed that the activity of NSE varied dependingon sex and age in PD patients, the stage and rate of progression of disease, age debut and severity of cognitive impairment. Thus, determination of NSE in the serum of PD patients should be included in the complex examination of patients with PD, as an additional marker of the neurodegenerative process.
Clinical manifestations in Bickerstaff encephalitis
Authors: Valikova T. A. , Pugachenko N. V. , Golikova N. B. , Alifirova V. M. , Azhermacheva M. N.
Published: June 2020

This article describes the clinical case of brainstem encephalitis and criteria correspond to the clinical criteria for Bickerstaff encephalitis.In domestic literature, we not found descriptions of this pathology and decided to describe their own clinical case.
The role of reflex-pain syndrome of osteochondrosis and spondyloarthrosis in the results of surgical treatment compressive syndrome offers by disc gerniation (diagnostics and neuron-surgical treatment)
Authors: Kolotov Ye. B. , Aminov R. R. , Yelagin S. V. , Kelmakov V. V. , Kolotova Ye. V.
Published: June 2020

To improve the results of surgical treatment the patients with discogenic compressive syndromes. Using the denervation of interbody discs and facet joints in series allow us, first off all, to induce, and then to discontinue the reflex-pain syndrome in 41 patients in preoperational period, and in 39 patients in long-term postoperative period. Good results come to 82,8 и 89,8% (р < 0,05) accordingly.
Features vertebroneurological status in patients with nodular transformation of thyroid mation
Authors: Spirin N. N. , Alexandrov Yu. K. , Kasatkin Ye. L. , Nikanorova T. Yu. , Sencha A. N.
Published: June 2020

Pathological processes in the thyroid and the cervical spine through the structures of the autonomic nervous system may provide each other mutual influence. Detection of additional pathogenetic factors in uzloobrazovaniya help develop additional methods of treatment and prevention tireopaty.
Ways to improve quality of endoscopic sphincterotomy in difficult technic cases
Authors: Yurchenko V. V. , Zykov S. A.
Published: June 2020

During examining endoscopic sphincterotomy difficulties to be discovered that the small papilla of Vater cause technological problems of identification common bile duct orice. The best way to overcame that difficulties is performing of of hepar bile ductes punction with endoscopic common bile duct orice identification.
Ambivalence of the person’s and culture’s Freudian concept of deviating behaviour’s context
Authors: Sysoyeva L. S.
Published: June 2020

Freudian concept of deviating behaviour’s context is considered how duality in understanding of the person’s nature with primate of Lüstprinzip and Tanatos to social and cultural base brings about to certain justification of human behaviour’s deviations. And even disgruntles the culture. The Temptation of deviations is concluded in following. Than is call in question social explanation of deviating conduct.
Ultrastructural and quantitative analysis of cellular elements in the periodontal ligament premolars
Authors: Khertek M. V. , Logvinov S. V.
Published: June 2020

A calculation and ultrastructural analysis of cellular elements in the periodontal ligament premolars with different surfaces (medial, distal, buccal and palatal) and at different levels of the roots. It is shown that the biomechanical load on the morphology of the premolars periodontal changes throughout the root, depending on the location of zones of compression and tension. Content of cells in the periodontium depends on the surface and the level of the tooth root.
On conditions of validity of diagnostic hypotheses
Authors: Dun Ye. M.
Published: June 2020

An attempt is undertaken to show the specific character of general methodological principles of hypothesis validity in clinical diagnostics.
Bronchial asthma and helminth invasion: particularity of the cellular immunity
Authors: Eliseyeva O. V.
Published: June 2020

In this review we discuss the mechanisms of human immune response modification by helminth in bronchial asthma. Helminth invasion causes increase of level to regulatory T-cells and to suppression of an allergic inflammation in bronchial asthma. Antihelminth therapy leads to decrease of level Treg cells. Deficiency or dysfunction of Treg cells can be a cause of allergic diseases.
Immunosuppression factors under various pathologies
Authors: Churina Ye. G. , Novitsky V. V. , Urazova O. I.
Published: June 2020

Until recent time it has seemed obvious that suppressive function in the immune system is provided by one subpopulation of Tlymphocytes-suppressors. At present it is usually considered that regulatory cells (T-reg) are key cells-suppressors of the immune response. There exist two main mechanisms of T-reg immunosuppression realization: direct (when there is direct contact between cells) and distant (cytokine-dependent). For suppression of the immune response Т-reg cells produce cytokines with suppression activity: TGF-β, IL-10, IFN-γ, IL-35. Meanwhile the increasing number of facts indicates that suppression of the immune response is a multi-component process. A considerable role in suppression of the immune response is assigned to the endocrine system. However, immunosuppression mechanisms under infection, neoplastic processes and the influence of xenobiotics on the organism are not completely clear.
Clinic-epidemiologic characteristic of viral hepatitis B in children in the Tomsk Region (1994—2009)
Authors: Korobeinikova S. B. , Chuikova K. I. , Katanakhova L. L.
Published: June 2020

The problem of parenteral viral hepatitis, in particular, viral hepatitis B (VHB), is urgent till now owing to some social, economic, and epidemiologic factors. The paper analyzes clinic-epidemiologic VHB indices in children for 1994—2009 in the Tomsk Region. The analysis includes 311 patients with acute and chronic VHB aged from 1 month to 18 years. The patients were treated in infectious hospitals of the city of Tomsk and Tomsk Region for the period of 1994 to 2009. Both clinic (short preicteric period, incomplete recovery after the normal hospitalization period) and epidemiologic (alternation of infection ways with time and their dependence on age, predomination of schoolchildren in the VHB age structure) VHB features are revealed.
Clinical anatomy of adrenal blood supply in different aged groups
Authors: Mitrofanova M. S.
Published: June 2020

Renal blood supply sources of adrenals in the norm are studied in the work as well as blood supply peculiarities of unilateral adrenal and kidney in renal artery stenosis are revealed. It is concluded that including the study of adrenal arteries into angiographic algorithm in case of renal artery stenosis is of necessity.