bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulation of tolerances of associated parts of mechanisms of livestock farms during repair
Authors: Alijanov D , Sakhrov V , Jumatov Ya , Turdibekov A
Published: September 2023

The paper considers an algorithm for optimizing the efficient distribution of resources that determine the cost of assembly work, subject to restrictions that ensure high quality assembly of livestock machines and equipment. To determine the required tolerance values for parts, one can use the known methods of parametric optimization. Therefore, the application to the solution of the problem of the method of Lagrangian multipliers as a result of the calculations obtained the optimal tolerances of the details of the angle. Upon completion of the calculations, the optimal assembly parameters of the node for various values are obtained; the result is presented in graphical form. There are various methods for calculating component tolerances of mating parts. Methods based on the statistical evaluation of tolerances and finding their root-mean-square deviations make it possible to reduce the degree of risk when expanding the tolerance limits for mating parts and reduce assembly losses. The correct assignment of tolerances allows one to achieve significant savings in material resources and reduce production costs. The most effective solutions may be those obtained by implementing optimization procedures that ensure the minimization of the quality criterion under the conditions of restrictions determined by the components of the assembly assembly process.
Cleaning of transformer oils using the electric field
Authors: Yusupov D T , Avazov B K , Kutbidinov O M , Bazarov M
Published: September 2023

A used oil sample of KTPJO 10/27.5/023 of power transformers which are used on the railway was selected and cleaned by means of electric field. This process was carried out using a device assembled on the basis of a special scheme. Unrefined and refined oil samples were tested for electrical strength, i.e. breakdown voltage, on AID-70m and HUAZHENG (HZJQ-X1 Transformer Oil BDV Tester) dielectric testers. The results were compared and analyzed by the regression method. It was determined that the operational characteristics of the oil were improved.
Development and study of adsorption properties of a new sulfur polyvinyl chloride cation exchanger for water treatment
Authors: Yusupov Farxod , Kucharov Azizbek , Baymatova Gulnoza , Shukurullayev Botir , Yuldashev Rezhabboy
Published: September 2023

The article analyses the sorption properties of thermally and chemically stable sulfonic cation exchange resin based on PVC. The article presents the temperature dependence of the analysis results of the sorption properties of Ca2+ and Mg2+ ions of sulfonated PVC. The results of the obtained sorption analysis are scientifically confirmed in the article. In addition, spatial Bode angle diagrams are presented, which provide very important scientific evidence of single maxima at intermediate frequencies. Purification of industrial waste water of enterprises was carried out with the help of the obtained sulfonic cation exchanger.
The effectiveness of various doses of magnesium-containing fertilizers in the cultivation of winter rapeseed
Authors: Akanova Natalia , Kozlova Alevtina , Esipenko Sergey , Zhivotovskaya Elena , Seregina Inga
Published: September 2023

The effect of various doses and forms of magnesium-containing fertilizers on the production process of winter rapeseed plants was studied in field experiments. It was found that the combined use of Agromag magnesium-containing fertilizers contributed to an increase in the yield of winter rapeseed plants. An increase in the dose of magnesium-containing fertilizers did not lead to an increase in the efficiency of applied fertilizers. The use of magnesium-containing fertilizers containing sulfur has led to an increase in the efficiency of fertilizers due to an increase in the mass of seeds per 1 plant.
Energy intensity of the device for lifting the soil of the machine for pre-sowing soil preparation and sowing
Authors: Syromyatnikov Yuriy , Orekhovskaya Alexandra , Klyosov Dmitriy , Taraban Maria , Yao Lubov , Zagidullin Ramil
Published: September 2023

The subject of the study is the process of the machine for preparing the soil and sowing sunflower and corn seeds. The technological process of operation of the machine with installed guide passive rotating flat discs with ridges seeding apparatus, seed line, furrow, rotor, separating grid, parallelogram mechanism, spring, plumeshare is described. Studies have been carried out at reducing the energy consumption of the device for lifting the soil by installing support drums between the guide disks, the radius of rotation of which is less than the radius of the disks. It is determined that in order to obtain the minimum values of the kinematic parameter at the lowest energy consumption, the radius of the guide discs must be chosen, based on the conditions of the depth of seed embedding in the soil, the smallest. With an increase in the coefficient of adhesion, the traction resistance of the working section of the tillage machine increases more significantly than the kinematic parameter. Therefore, in order to reduce the traction resistance, it is necessary to strive to reduce the coefficient of adhesion of the drum with the soil.
Advanced front plow
Authors: Mamato F , Kh Shomirzaev M , Badalov S , Rakhmatov D , Choriev I
Published: September 2023

The process of smooth plowing with the turnover of layers within its own furrow is characterized by high energy costs due to the interaction of the plow body and the plow in conditions of blocked cutting. The purpose of the research is to substantiate the type of the second-rear body of the frontal plow. The proposed front plow for smooth plowing contains twin screw housings, first-row colliders, rear screw right- and left-turning plow housings, second-row colliders. Screw right- and left-turning plow housings are equipped with mirror-mounted screw shortened stabilizing plates. The transverse distance from the field cutoff to the front of the stabilizing plate is greater than the width of the body grip. As a result, the rear bodies work in a semi-open furrow, which helps to reduce the traction resistance of the plow. The results of experimental studies to substantiate the type of rear enclosures are presented. Experiments were carried out with the following types of rear housings: cultured, semi-screw, screw and screw housing with a guide plate. It is established that when performing the rear screw housings and equipping them with guide plates, the quality indicators of the plow fully comply with agro technical requirements. At the same time, the degree of embedding of plant residues and the height of irregularities is 92-95% and 4.3-5 cm, respectively.
Technologies to reduce water waste during land leaching and cultivation of industrial crops
Authors: Begmatov I , Kh Khajiev M , Atadjanova M M
Published: September 2023

More than half of Uzbekistan’s irrigated land is saline to some degree. The drying up of the Aral Sea has intensified this process. Chronic salt storms in the northern part of the country have for many years sprayed large quantities of salt onto agricultural land, leading to increased salinisation. These processes cause the water required to flush saline soils year after year. The problem is exacerbated by water shortages worldwide, including in Central Asia. This requires leaching of saline soils and a multiplication of the water used in crop cultivation. Therefore, alternative use of water resources in our country is one of the most important issues for agriculture. Introduction of salt leaching and cultivation in farms on the basis of outdated technologies and low efficiency of new technologies (bio-solvent washing, etc.) in production of new salt leaching and cultivation remain a negative obstacle for economic development of farms and the country as a whole. The analysis shows that in our country billions of cubic meters of water are used for flushing of saline soils and cultivation of agricultural crops, but only 60% of this water reaches the fields where crops are grown, while the rest of it disappears into the irrigation systems and irrigation processes (canals, ditches and branch lines). When providing water resources for soil salinisation and cultivation by means of trapezoidal canals, part of the water flowing through them dissolves and filters the mineral and organic fertilizers in the soil due to air pressure and gravity, as a result up to 30% of water is lost (wasted). In this paper the water resources for soil washing and crop cultivation are replaced by a parabolic excavator with a trapezoidal boom, designed to save up to 30% of water resources.
Parameters of the deep loader of the mole drainage gun
Authors: Maiviatov F M , Kh Shomirzaev M , Rajabov Y , Temirov I G , Sh Chuyanov D
Published: September 2023

The purpose of the study is to substantiate the parameters of the deep-loader of the mole-drainage gun. A diagram of a mole-drainage gun is given. The main working parts of the mole drainage tool are a deep loader, a knife, a rope and a drainer. Analytical dependences are obtained for determining the main parameters and traction resistance of the deep-loader of the mole-drainage gun. Theoretical studies have established that for high-quality loosening of the soil with minimal traction resistance, the height of the deep digger should be 90 cm, the width of its chisel is 7 cm, the angle of the chisel to the horizon is within 26-320, the length of the chisel is 11.5 cm, and the sharpening angle is 250. Installing a knife on a deep-loader increases the density of the dredge wall by 1.45-1.48 times, the depth of the dredge laying by 1.15 times, while the traction resistance of the mole-drainage gun decreases by 12.9%.
Soil treatment in various agricultural landscapes
Authors: Kozulina Natalia , Lipshin Alexey , Bobrovsky Alexander , Vasilenko Albina
Published: September 2023

Tillage is an important element of crop cultivation technology in the Krasnoyarsk Territory. The main processing solves such technological problems as deepening the arable layer due to the underlying layers or horizons, crumbling and loosening the soil, which ensures a change in the relative position of soil units with an increase in the number of pores, mixing and leveling the soil. Particular attention during the main processing should be paid to the quality of its implementation and the compliance of the soil after processing with agrotechnical requirements for the depth of processing, the uniformity of the depth of processing, the lumpiness of the surface, the rowness of arable land, and the looseness of the soil.
Optimizing the parameters of the air disc atomizer for the low volume desalination spraying of cotton crops
Authors: Utepov B B , Khaydarov T A , Rajabov N Q , Murtazayeva G R , Kulmamatova B O , Kh Durdiyev N
Published: September 2023

The article presents the results of a multi-factorial experiment to justify the parameters of a rotating sprayer. Optimization of the parameters of the pneumatic disk atomizer shows that with the correct choice of the specific liquid flow rate (qi), disk radius (r) and the number of radial channels (η
r) at a constant air flow rate, it leads to obtaining the required median-mass droplet diameter. Therefore, when justifying the diameter of sprayed drops, it is necessary to consider a combination of the specific flow rate of the liquid and the radius of the disk. To obtain a monodisperse spray of drops with a median-mass diameter d= 80…120 µm, the disc radius should be in the aisles r=75.8…83.4 mm, the specific liquid flow rate qi= 0.61…0.96 l/min and the number of radial channels for pairs of disks in the aisles η
p = 4.59… 5.75 things.
Performance analysis of UAV sprayer application in precision agriculture
Authors: Kovalev I V , Kovalev D I , Astanakulov K D , Shaporova Z E , Podoplelova V A , Borovinsky D V
Published: September 2023

The effectiveness of the use of spray UAVs in precision agriculture largely depends both on the UAVs chosen for this purpose and their characteristics, and on the organization of the control of the UAV swarm, which requires an analysis of the UAV microprocessor performance in various modes of their use. It is possible to organize a general control of a swarm of UAVs, as well as individual control in offline mode. The article presents a methodology for analyzing the performance of spray UAVs in precision agriculture. A model example of the analysis of the microprocessor performance of a UAV swarm based on the specified system parameters is given. It is shown that the use of models of microprocessor performance of a swarm of UAVs in precision farming makes it possible to obtain the information necessary to make a decision on the development or purchase of UAVs of one type or another, the choice of fertilizer and pesticide spraying systems, the scaling and redundancy of UAVs and elements of the spraying system.
Methodology for calculating the characteristics of linear induction motors for low-speed process equipment
Authors: Yunusov Rustem F , Parmanov Abdulla E , Karimov Ilxom N , Rajabov Muzaffar N , Tuxtayev Bobur B , Raxmonov Shaxobiddin S
Published: September 2023

An analysis of the drive characteristics of technological machines and mechanisms of agricultural production showed that their working bodies in 56.3% of cases have rotational motion, and in 43.7% they have translational motion. Special electromechanical and electromagnetic converters - an electric drive with a linear asynchronous motor - are very promising for driving the working bodies of technological equipment that perform translational and oscillatory motion, as well as rotational motion with a rotation speed of up to 500 min−1. A linear asynchronous electric drive makes it possible to implement technologically specified drive characteristics, integrate the power parts of an electric motor with a working body with the exception of mechanical converters, while reducing material and energy consumption, increasing operational reliability of process equipment as a whole. The choice of the optimal winding scheme and the design of the magnetic circuit of the inductor, the material of the secondary element increases the energy and traction performance of the linear induction motor. The study and modeling of electromagnetic processes and the optimization of geometric dimensions, winding data of the inductor and electrical parameters can be effectively carried out on a mathematical model of a linear induction motor by a numerical method, represented by a system of three matrix equations describing the states of the magnetic and electrical circuits of the machine, detailed to the level of tooth division and winding section.
Investigation of processes in the separation zone of cotton production using computer graphics
Authors: Ravutov Sh T , Pirnazarov Sh , Esanov E E
Published: September 2023

The article deals with the issues of improving the quality of the work of the cotton separation zone of the vertical spindle of the cotton spinning machine from the spindle, as well as the theoretical justification of the main parameters. The authors analyze the problems of technological processes in the separation zone of cotton production. For graphic construction and calculations, the COMPASS-GRAPH program was used. An analytical expression is found for a curved line in which the spindle is located in the center of the separator. Recommendations are given for the placement of the separator, based on the number of parts under the influence of the brushes of the cotton separator, the angle of rotation of the spindle around its axis in the process of interaction, and the operating time of the separator.
Modeling the process of growing seeds of vegetable crops with ultraviolet light
Authors: Bayzakov Taxir , Yusupov Sharofiddin , Yunusov Rustem , Xolmirzaev Ilxom , Esanov Jahongir , Kulmamatova Shakhnoza
Published: September 2023

The article discusses measures to prevent the shortage of vegetable and vegetable crops, increase their yield. In order to meet the demand of the population for these products if necessary to have export potential it is necessary to apply the achievements of modern science to the products grown. The use of new modern technologies will make a significant contribution to the development of the agricultural sector. When growing products in agriculture, traditional methods that require a lot of work should be abandoned. In this article there are seeds of muhima ahamita when growing crops. Germination and good crop development indicate the need to use modern technologies in seed processing. At the same time, it is necessary to take into account the cultivation of seeds and several factors affecting it. When treating seeds with ultraviolet radiation, it is necessary to study the effect of the exposure dose of light.
Features of calculating structures for frequent weak earthquakes
Authors: Belashov M , Benin A V , Hong Lin , Nazarova Sh Sh , Sabirova O B , Uzdin A M
Published: September 2023

The features of calculating structures for the action of weak earthquakes are analyzed. Earthquakes with a recurrence of 30 years and 50 years are considered. In the first case the structure is to operate normally without damage after the earthquake. In the second case damages are allowed that do not affect the possibility of the structure operation. Three issues are emphasized: setting elastic and damping characteristics of reinforced concrete, formalization of limit states and combinations of loads. The dependence of damping on the reinforcement coefficient is estimated. When evaluating limit states, in addition to calculations for crack resistance and strength, a human factor, i.e. the possibility of panic among people was considered. To avoid it, it is proposed to limit a storey-by-storey speed level in certain octave ranges. Proposals have been developed for estimating the coefficients of combination of various loads with the seismic one. As an example, coefficients of combinations of seismic and ice loads are estimated. It is shown, that for strong actions the combination coefficients for different regions turn out to be close, while for weak actions they may differ.
The influence of environmental factors on the composition and structure of associations of plant communities of floodplain meadows
Authors: Kh Nechaeva E , Ermakova N A , Stepanova Yu V , Redin D V , Tsarevskaya V M
Published: September 2023

The article discusses the patterns of formation of plant associations in the composition of meadow, floodplain phytocenoses, depending on environmental factors. The aim of this research is to determine the stability of the ecosystem as a whole, since the most important indicator of the state of the ecosystem is the structure of the vegetation cover of the soil. Monitoring of plant communities was carried out and the influence of a number of environmental factors on the composition and structure of meadow associations of floodplain meadows was studied.
Development of a model for forecasting the inflow to the site of a hydroelectric power plant using neural models for information processing
Authors: Grebnev Y V , Moskalev A K , Petrunina A E , Lazutin D T
Published: September 2023

Information technologies have entered all spheres of human life. Now they are an integral part of the modern world. These changes also affected the anti-crisis management system. The development of end-to-end technologies and the use of artificial intelligence allows for a better assessment and forecasting of risks. The methods used for forecasting the inflow to the site of a hydroelectric power station were analyzed in this paper. The data necessary to obtain a forecast were reviewed. An approach related to forecasting the inflow to the site of a hydroelectric power station using neural network forecasting methods is demonstrated. Using the python programming language, a neural network model was developed to predict the inflow to the hydroelectric station site. A recurrent network with a long short-term memory LSTM using 64 neurons was chosen as the network architecture. The data array for forecasting was obtained from the data of operational monitoring of the flood situation and archival data on flooding of the territory over the past 13 years, taken from the database of the Yenisei Basin Water Administration of the Federal Agency for Water Resources and the Central Siberian UGMS. The input parameters were selected empirically. When comparing real data on flow with the predicted ones, the error was 17%.
The importance of soil and water for increasing the strength of ceramic products
Authors: Razzaqov S J , Jurayev Sh Sh , Xakimov Sh A , Qayumov D A , Yuldashev J G
Published: September 2023

The article presents data reflecting the physicochemical and physical and mechanical properties of the soil used as a raw material for the production of brick products. The authors describe the data reflecting the fundamental difference between electro activated water underlying the proposed technological method, compared with ordinary water. When analysing the results of studying the chemical composition of the soil, the average value of the hydrogen index, which is a soil solution, corresponds to 7.6, and the average amount of acid anions and the average amount of basic ion-cations composition is compared with the average amount of basic ion-cations (6.48: 2.7) turned out to be 2.4 times more. The authors make the conclusion that the soil reserve used for production is acidic.
MoleculeExperiment enables consistent infrastructure for molecule-resolved spatial omics data in bioconductor
Authors: Peters Couto Bárbara Zita , Robertson Nicholas , Patrick Ellis , Ghazanfar Shila
Published: September 2023

Motivation

Imaging-based spatial transcriptomics (ST) technologies have achieved subcellular resolution, enabling detection of individual molecules in their native tissue context. Data associated with these technologies promise unprecedented opportunity toward understanding cellular and subcellular biology. However, in R/Bioconductor, there is a scarcity of existing computational infrastructure to represent such data, and particularly to summarize and transform it for existing widely adopted computational tools in single-cell transcriptomics analysis, including SingleCellExperiment and SpatialExperiment (SPE) classes. With the emergence of several commercial offerings of imaging-based ST, there is a pressing need to develop consistent data structure standards for these technologies at the individual molecule-level.

Results

To this end, we have developed MoleculeExperiment, an R/Bioconductor package, which (i) stores molecule and cell segmentation boundary information at the molecule-level, (ii) standardizes this molecule-level information across different imaging-based ST technologies, including 10× Genomics’ Xenium, and (iii) streamlines transition from a MoleculeExperiment object to a SpatialExperiment object. Overall, MoleculeExperiment is generally applicable as a data infrastructure class for consistent analysis of molecule-resolved spatial omics data.

Availability and implementation

The MoleculeExperiment package is publicly available on Bioconductor at https://bioconductor.org/packages/release/bioc/html/MoleculeExperiment.html. Source code is available on Github at: https://github.com/SydneyBioX/MoleculeExperiment. The vignette for MoleculeExperiment can be found at https://bioconductor.org/packages/release/bioc/html/MoleculeExperiment.html.
Interaction of pre- and postnatal nutrition on expression of leptin receptor variants and transporter molecules, leptin transport, and functional response to leptin in heifers
Authors: Williams Gary L , Zhang Youwen , O’Neil Meaghan M , Maia Tatiane S , West Sarah M , Alves Bruna R C , Garza Viviana , Welsh Jr Thomas H , Cardoso Rodolfo C
Published: September 2023

Perinatal nutrition modulates the hypothalamic neurocircuitries controlling GnRH release, thus programming pubertal maturation in female mammals. Objectives of experiments reported here were to test the hypotheses that prenatal nutrition during mid- to late gestation interacts with postnatal nutrition during the juvenile period in heifer offspring to alter expression of leptin receptor (LepR) variants (ObRa, ObRb, ObRc, ObRt), and lipoprotein transporter molecules (LRP1 and 2) in the choroid plexus, leptin transport across the blood–brain barrier, and hypothalamic–hypophyseal responsiveness to exogenous ovine leptin (oleptin) during fasting. Nutritional programming of heifers employed a 3 × 2 factorial design of maternal (high, H; low, L; and moderate, M) × postnatal (H and L) dietary treatments. Results (Expt. 1) demonstrated that prepubertal heifers born to L dams, regardless of postnatal diet, had reduced expression of the short isoform of ObRc compared to H and M dams, with sporadic effects of undernutrition (L or LL) on ObRb, ObRt, and LRP1. Intravenous administration of oleptin to a selected postpubertal group (HH, MH, LL) of ovariectomized, estradiol-implanted heifers fasted for 56 h (Expt. 2) did not create detectable increases in third ventricle cerebrospinal fluid but increased gonadotropin secretion in all nutritional groups tested. Previous work has shown that leptin enhances gonadotropin secretion during fasting via effects at both hypothalamic and anterior pituitary levels in cattle. Given the apparent lack of robust transfer of leptin across the blood–brain barrier in the current study, effects of leptin at the adenohypophyseal level may predominate in this experimental model.
Sustained induction of IP-10 by MRP8/14 via the IFNβ–IRF7 axis in macrophages exaggerates lung injury in endotoxemic mice
Authors: Wang Juan , Chen Guiming , Li Lei , Luo Sidan , Hu Bingrong , Xu Jia , Luo Haihua , Li Shan , Jiang Yong
Published: September 2023

Background

As a damage-associated molecular pattern, the myeloid-related protein 8/14 (MRP8/14) heterodimer mediates various inflammatory diseases, such as sepsis. However, how MRP8/14 promotes lung injury by regulating the inflammatory response during endotoxemia remains largely unknown. This study aims at illuminating the pathological functions of MRP8/14 in endotoxemia.

Methods

An endotoxemic model was prepared with wild-type and myeloid cell-specific Mrp8 deletion (Mrp8ΔMC) mice for evaluating plasma cytokine levels. Lung injury was evaluated by hematoxylin and eosin (H&E) staining, injury scoring and wet-to-dry weight (W/D) ratio. The dynamic profile of interferon γ (IFNγ)-inducible protein 10 (IP-10) mRNA expression induced by macrophage MRP8/14 was determined by quantitative real-time polymerase chain reaction (qPCR). Immunoblotting was used to evaluate the increase in IP-10 level induced by activation of the JAK–STAT signaling pathway. Luciferase reporter assay was performed to detect the involvement of IRF7 in Ip-10 gene transcription. In vivo air pouch experiments were performed to determine the biological function of IP-10 induced by MRP8/14.

Results

Experiments with Mrp8ΔMC mice showed that MRP8/14 promoted the production of cytokines, including IP-10, in the bronchoalveolar lavage fluid (BALF) and lung injury in endotoxic mice. The result of qPCR showed sustained expression of Ip-10 mRNA in macrophages after treatment with MRP8/14 for 12 h. Neutralization experiments showed that the MRP8/14-induced Ip-10 expression in RAW264.7 cells was mediated by extracellular IFNβ. Western blotting with phosphorylation-specific antibodies showed that the JAK1/TYK2-STAT1 signaling pathway was activated in MRP8/14-treated RAW264.7 cells, leading to the upregulation of Ip-10 gene expression. IRF7 was further identified as a downstream regulator of the JAK–STAT pathway that mediated Ip-10 gene expression in macrophages treated with MRP8/14. In vivo air pouch experiments confirmed that the IFNβ-JAK1/TYK2-STAT1-IRF7 pathway was required for chemokine (C-X-C motif) receptor 3 (CXCR3)+ T lymphocyte migration, which promoted lung injury in the context of endotoxemia.

Conclusions

In summary, our study demonstrates that MRP8/14 induces sustained production of IP-10 via the IFNβ-JAK1/TYK2-STAT1-IRF7 pathway to attract CXCR3+ T lymphocytes into lung tissues and ultimately results in lung injury by an excessive inflammatory response in the context of endotoxemia.
High Burden of COVID-19-Associated Pulmonary Aspergillosis in Severely Immunocompromised Patients Requiring Mechanical Ventilation
Authors: Feys Simon , Lagrou Katrien , Lauwers Hanne Moon , Haenen Koen , Jacobs Cato , Brusselmans Marius , Debaveye Yves , Hermans Greet , Hoenigl Martin , Maertens Johan , Meersseman Philippe , Peetermans Marijke , Spriet Isabel , Vandenbriele Christophe , Vanderbeke Lore , Vos Robin , Van Wijngaerden Eric , Wilmer Alexander , Wauters Joost
Published: September 2023

Background

Coronavirus disease 2019 (COVID-19)–associated pulmonary aspergillosis (CAPA) is a frequent superinfection in critically ill patients with COVID-19 and is associated with increased mortality rates. The increasing proportion of severely immunocompromised patients with COVID-19 who require mechanical ventilation warrants research into the incidence and impact of CAPA during the vaccination era.

Methods

We performed a retrospective, monocentric, observational study. We collected data from adult patients with severe COVID-19 requiring mechanical ventilation who were admitted to the intensive care unit (ICU) of University Hospitals Leuven, a tertiary referral center, between 1 March 2020 and 14 November 2022. Probable or proven CAPA was diagnosed according to the 2020 European Confederation for Medical Mycology/International Society for Human and Animal Mycology (ECMM/ISHAM) criteria.

Results

We included 335 patients. Bronchoalveolar lavage sampling was performed in 300 (90%), and CAPA was diagnosed in 112 (33%). The incidence of CAPA was 62% (50 of 81 patients) in European Organisation for Research and Treatment of Cancer (EORTC)/Mycosis Study Group Education and Research Consortium (MSGERC) host factor–positive patients, compared with 24% (62 of 254) in host factor–negative patients. The incidence of CAPA was significantly higher in the vaccination era, increasing from 24% (57 of 241) in patients admitted to the ICU before October 2021 to 59% (55 of 94) in those admitted since then. Both EORTC/MSGERC host factors and ICU admission in the vaccination era were independently associated with CAPA development. CAPA remained an independent risk factor associated with mortality risk during the vaccination era.

Conclusions

The presence of EORTC/MSGERC host factors for invasive mold disease is associated with increased CAPA incidence and worse outcome parameters, and it is the main driver for the significantly higher incidence of CAPA in the vaccination era. Our findings warrant investigation of antifungal prophylaxis in critically ill patients with COVID-19.
Joan Robinson through the lenses of sixty years of book reviews
Authors: Marcuzzo Maria Cristina , Zacchia Giulia
Published: September 2023

In this paper, we discuss Joan Robinson’s views through the lenses of her 127 book reviews, an activity which she engaged in throughout her life. A complete list of them—so we hope—is presented with full reference to the original place of publication, in the form of tables arranged by decade. We follow her work in chronological order, taking each decade as the framework to analyse what she was working on at the time and show how her reviews were—at times loosely, at times closely—connected with her scientific and political concerns. In some cases, the reviews amounted to review essays, which she reprinted in her Collected Economic Papers, but even in the short reviews she managed to give full expression to her views on the topic or author, and thus they offer us additional insights into her mode of thought, examples of her crisp prose and forceful style of argument. Her reviews ranged over a great variety of topics, reflecting over 60 years of the development of economics, or at least those aspects and topics which she deemed relevant at the time, and so they come to form part of her intellectual legacy, as much as her published work.
Kalecki’s notes on Robinson’s Essay on Marxian Economics
Authors: Toporowski Jan
Published: September 2023

This essay presents Kalecki’s notes on Joan Robinson’s Essay on Marxian Economics, (hitherto published only in a Polish translation) introduced by an explanation of the part that Kalecki’s work played in Robinson’s reconsideration of Marx in the light of the new ideas coming from Keynes and Kalecki. Kalecki defended Marx against Robinson’s more extreme accusations of inconsistency. Kalecki’s notes are given in an appendix to this essay.
Genome and transcriptome analyses reveal genes involved in the formation of fine ridges on petal epidermal cells in Hibiscus trionum
Authors: Koshimizu Shizuka , Masuda Sachiko , Shibata Arisa , Ishii Takayoshi , Shirasu Ken , Hoshino Atsushi , Arita Masanori
Published: September 2023

Hibiscus trionum, commonly known as the ‘Flower of an Hour’, is an easily cultivated plant in the Malvaceae family that is widespread in tropical and temperate regions, including drylands. The purple base part of its petal exhibits structural colour due to the fine ridges on the epidermal cell surface, and the molecular mechanism of ridge formation has been actively investigated. We performed genome sequencing of H. trionum using a long-read sequencing technology with transcriptome and pathway analyses to identify candidate genes for fine structure formation. The ortholog of AtSHINE1, which is involved in the biosynthesis of cuticular wax in Arabidopsis thaliana, was significantly overexpressed in the iridescent tissue. In addition, orthologs of AtCUS2 and AtCYP77A, which contribute to cutin synthesis, were also overexpressed. Our results provide important insights into the formation of fine ridges on epidermal cells in plants using H. trionum as a model.
Glycogen storage disease with massive left ventricular hypertrophy and increased native T1: a case report
Authors: Wang Jie , Pu Lutong , Han Yuchi , Chen Yucheng
Published: September 2023

Background

Glycogen storage disease (GSD) type Ⅲa is a rare autosomal recessive disorder resulting in the accumulation of abnormally structured glycogen in the liver, skeletal muscle, and cardiac muscle. Cardiovascular magnetic resonance (CMR) tissue characteristics in GSD have rarely been reported.

Case summary

We report a 24-year-old male patient suffering from recurrent palpitation and atypical chest pain for 5 years with suspected hypertrophic cardiomyopathy. Laboratory tests revealed an elevated creatine kinase, and physical exam revealed hepatosplenomegaly. Cardiovascular magnetic resonance demonstrated asymmetrical massive left ventricular hypertrophy with a maximal thickness of 34.6 mm in the septum. In the regions with focal late gadolinium enhancement (LGE) in the anterior septum, both native T1 and extracellular volume (ECV) are elevated. However, in the LGE-negative regions of the myocardium, native T1 was elevated without elevation in ECV (septum, 22.7%; free wall, 20.9%). Whole exome sequencing revealed a novel pathogenic homozygous nonsense variant of the AGL gene (c.4284 T > G, p. Tyr1428*), confirming the diagnosis of the patients as GSD type Ⅲa.

Discussion

This case showed increased diffuse native T1 but not ECV on CMR in LGE-negative myocardium in GSD, which indicates that the T1 value is increased with an accumulation of glycogen in the myocardium, but the ECV space was not expanded in this process. Genetic testing should be obtained in severe LV hypertrophy when multi-organ involvement is present, and myocardial tissue characterization is discrepant between T1 elevation and normal ECV to consider glycogen storage disorder.
Identification of a second genetic alteration in patients withSHOXdeficiency individuals: a potential explanation for phenotype variability
Authors: Dantas Naiara C B , Funari Mariana F A , Lerário Antonio M , Andrade Nathalia L M , Rezende Raíssa C , Cellin Laurana P , Alves Crésio , Crisostomo Lindiane G , Arnhold Ivo J P , Mendonca Berenice , Scalco Renata C , Jorge Alexander A L
Published: September 2023

Objective

Our study aimed to assess the impact of genetic modifiers on the significant variation in phenotype that is observed in individuals with SHOX deficiency, which is the most prevalent monogenic cause of short stature.

Design and methods

We performed a genetic analysis in 98 individuals from 48 families with SHOX deficiency with a target panel designed to capture the entire SHOX genomic region and 114 other genes that modulate growth and/or SHOX action. We prioritized rare potentially deleterious variants.

Results

We did not identify potential deleterious variants in the promoter or intronic regions of the SHOX genomic locus. In contrast, we found eight heterozygous variants in 11 individuals from nine families in genes with a potential role as genetic modifiers. In addition to a previously described likely pathogenic (LP) variant in CYP26C1 observed in two families, we identified LP variants in PTHLH and ACAN, and variants of uncertain significance in NPR2, RUNX2, and TP53 in more affected individuals from families with SHOX deficiency. Families with a SHOX alteration restricted to the regulatory region had a higher prevalence of a second likely pathogenic variant (27%) than families with an alteration compromising the SHOX coding region (2.9%, P = .04).

Conclusion

In conclusion, variants in genes related to the growth plate have a potential role as genetic modifiers of the phenotype in individuals with SHOX deficiency. In individuals with SHOX alterations restricted to the regulatory region, a second alteration could be critical to determine the penetrance and expression of the phenotype.
S2-4 Physical literacy in Denmark: from concept to intervention
Authors: Elsborg Peter , Melby Paulina S , Kurtzhals Mette , Ryom Knud , Nielsen Glen , Bentsen Peter
Published: September 2023

Purpose

Physical literacy (PL) is a holistic concept describing individuals’ prerequisites for engaging in physical activities through the life course. Interest in research on PL has increased rapidly in Denmark in the recent years. Researchers from the three largest universities, the largest university college, as well as research centers at two regional university hospitals have initiated projects with either PL as their core subject or using PL as a guiding theoretical framework for or as an outcome of physical activity interventions. These research projects have a conceptual purpose (Elsborg, Ryom, et al., 2021), a methodological purpose such as development of assessment tools (Elsborg, Melby, et al., 2021), and a purpose of investigating health-related correlates (Elsborg, Heinze, et al., 2021; Melby et al., 2021). Furthermore, interventional research projects that focus on how PL development is best stimulated in different age groups and target groups have recently begun (Ryom et al., 2021; Elsborg et al., 2021). The researchers that have been inspired by PL and are currently conducting PL research in Denmark come mainly from a motivational / sport and exercise psychological and/or public health background and have a strong focus on developing health promotion interventions. Many of the research projects in Denmark are supported by strong collaborations with field leading international researchers.

Methods

Interest and utilization of the concept has also undergone a prodigious development in Denmark from a practice and policy perspective. The national sport for all organisation, DGI, has incorporated PL as one of their key concepts which guides all their activities. The national school sports organisation, Danish School Sports, has also adopted the concept and have currently funded an industrial PhD project, which investigates health-related correlates to PL while also spreading knowledge about the concept in the organisation and in schools. In 2018, a national cross-sectoral network for PL interested parties was established (https://www.pl-net.dk).

Results and discussion

This presentation will focus on providing a short overview and discussion of the research, practice and policy development in Denmark while exemplifying this development by presenting the recent interest from several large-scale school-based intervention projects in more detail.
S4-5 Framework for evaluation of green spaces for physical activity to support public health policy in Slovenija
Authors: Erjavec Ina Šuklje , Kozamernik Jana , Žlender Vita , Koblar Simon
Published: September 2023

Purpose

Evidence suggests that green space use for physical activity significantly benefits to maintenance and improvement of public health. Settlements need to provide adequate access to public green spaces which enable and encourage physical activity. Provision of publicly accessible green spaces is therefore often included in different sectoral strategies and policies. However, to really meet goals and objectives, declared in these documents, appropriate and efficient actions need to be taken in spatial development practice on a local level.

Methods

We present the approach, developed within the first year of the national research project PREZENCA, which aims at developing indicators for the assessment of the provision of settlements with green spaces for outdoor physical activity in Slovenian municipalities. The approach may be of interest to countries which have adequately developed strategic spatial planning of urban green spaces but lack useful tools to assess the current state and to monitor changes in the provision of quality green and other outdoor spaces to encourage physical activity.

Results

The approach is based on a comprehensive analysis of examples and possibilities for measuring presence and quantity of green spaces, defining green space types, and measuring citizens’ accessibility and use of green spaces for physical activity. Content analysis of existing planning documents on a local level was carried out to elaborate: (1) whether the provision of green spaces in settlements in Slovenia is defined and how (2) which population groups are addressed and (3) where such content should be put into policy documents to support implementation in practice. Based on the results, the suggestions on relevant factors and indicators of green space provision and quality for physical activity were prepared to be further developed for evaluation and monitoring on the local level and included into spatial planning practice and policies.

Conclusion

Furthermore, we discuss the importance of establishing local standards and possibilities to include them into planning documents to form the basis for long-term monitoring of the condition of publicly accessible green spaces for recreational use by residents.
S8-1 Health Promoting Sports Federations: theory, tools, case studies and future directions
Authors:   Chair(s):, Van Hoye Aurélie , Geidne Susanna
Published: September 2023

Purpose

Beyond promoting their sports and contributing to elite success, sports federation have a broader health and sport for all promoting role, to include everyone in sport. The symposium has as objective to showcase theoretical grounds, case studies and tools to support health and physical activity promotion among international and national sports federation.

Methods

The symposium will entail four presentation reflecting on different aspects of health and physical activity promotion. The first presentation will focus on theoretical grounds and guidelines created by 15 researchers and in collaboration with the World Health Organisation. The second presentation describes a case study among 51 national sports federation in France, to explain how they promote health and showcase the use of the indicators of health promoting sports federation indicators created by authors of the first presentation. The third presentation will describe a World Athletics project on the promotion of physical activity through competitions organisation and its stakes, as a practice-oriented example. The fourth presentation offer insights on the development and use of the “International and European Sport Organisations Activate Citizens” Capacity Building Framework, created through an Erasmus+ project, which entails a set of tools to empower international sports federation to promote sport for all.

Results

After the four presentation, an open discussion will be engaged with the audience on the success and challenges, as well as a small interactive session on future directions for international and national sports federation to consider their health enhancing physical activity potential and fully exploit it.

Conclusions

The symposium will equip the audience with theory, tools and example of practice, as well as reflect on how to move the research and practice agenda for health promoting sport federation.
S11-1 From physical activity prescription to an active lifestyle: optimising the transfer
Authors:   Chair(s):, Lion Alexis , Füzéki Eszter , McDonough Suzanne , Pfeifer Klaus , Lipkens Luc , Aznar Susana , Titze Sylvia
Published: September 2023

Introduction

Physical activity (PA) is recommended to prevent and manage chronic diseases. Based on a wealth of scientific evidence, the World Health Organization (WHO) published specific PA recommendations for people with chronic diseases. However, people with chronic diseases are still not sufficiently physically active. To tackle this issue, the WHO published a recommendation to “implement systems of patient assessment and counselling on PA in primary and secondary health care and social services”. This symposium will present 4 European examples that (are willing to) implement strategies in healthcare settings to refer patients to PA programs.

Project/policy description

In Germany, an ongoing research project (BewegtVersorgt) aimed to develop, implement, and evaluate a PA referral scheme (PARS) to promote PA for persons with chronic diseases within the German healthcare system. The PARS was coproduced by twelve health sectors organisations under the guidance of a research team.

In Flanders (Belgium), general practitioners (GPs) can use PA Prescription (PAP) since 2017. More recently, a collaboration between different European regions was set up to implement a European Physical Activity on Prescription model (EUPAP), based on the Swedish model. In this model, all healthcare professionals can use PAP. Barriers and facilitators of the implementation of EUPAP in Flanders have been identified.

In Spain, a national PAP plan was developed by the creation of exercise units that will work together with PA referral (PAR) in all autonomic Communities in Spain. Digital tools are used to improve the accessibility and efficacy of the Community Sport and Health systems to provide PA for the inactive population with or without chronic disease.

In Austria, the Jackpot.fit program was developed by Austrian health insurance funds and aims to refer physically inactive adults via several approaches: letter sent by the health insurance company, word of mouth, newspapers, sport-club trainers, and GPs. The letter sent by the health insurance company was much more efficient in terms of patient referral than the other approaches.

Conclusions

These examples will open a discussion between the speakers and the symposium audience and will feed into the reflections of the Working Group on HEPA Promotion in healthcare settings.