bluuebunny/crossref_metadata_2025 huggingface dataset:
Manajemen Masalah Teknologi Informasi Berdasarkan Kerangka Kerja ITIL V3 dan COBIT 5
Authors: Effendy Faried , Hariyanti Eva
Published: December 2018

In this study, we attempted to develop Information Technology (IT) document of problem management for the export company. This document used as guidance for the company’s employees to manage IT problem. Not every company's IT division has IT problem management strategy, the priority of problem-solving is usually done by the First In first out (FIFO) method by not considering the impact and the problem urgency. COBIT 5 and ITIL V3 DSS03 related to Problem management were used as standards to review and benchmark on how problem management activities should be done. The output of this research is a Standard Operating Procedure (SOP) document. The Problem management SOP document consists of three stages, the first stage is the preparation of  SOP with 5 sub-stages, namely: list activity of ITIL V3 and COBIT 5 DSS03, mapping activity of ITIL V3 and COBIT 5 DSS03, verification of company new activities, mapping of activity actor based on RACI DSS02 and mapping of workproduct. The second stage is the adjustment of SOP documents with 2 sub-stages, namely: interviews for identification of needs and mapping of activity actor with the company's organizational structure. The third stage is the verification of SOP documents. The SOP documents contain 11 procedure with five actors. Overall SOP document can eventually become a reference for the company to manage IT problem.
Microstructure and cooking quality of barley-enriched pasta produced at different process parameters
Authors: Kosović Indira , Kosović Indira , Benšić Mirta , Benšić Mirta , Ačkar Đurđica , Ačkar Đurđica , Jozinović Antun , Jozinović Antun , Ugarčić Žaneta , Ugarčić Žaneta , Babić Jurislav , Babić Jurislav , Miličević Borislav , Miličević Borislav , Šubarić Drago , Šubarić Drago
Published: December 2018

Pasta is one of the most popular meals in the world. It is affordable, easy to combine with other foods and easy to cook. Unfortunately, pasta is energy-rich and nutrient-poor. Whole-wheat pasta is somewhat better in nutritional quality, but further improvements may be made. One option is to add different raw materials and specific nutritive components (vitamins, polyphenols, fiber, protein, etc.) to semolina. However, this approach changes its physico-chemical properties, e.g. cooking loss, texture, etc., which cannot be disregarded. The current research investigates possibilities for production of barley-enriched pasta with acceptable cooking qualities. To ensure the beneficial health effects of β-glucan, β-glucan-rich barley was selected asa starting material. Pasta enriched with 10–50% β-glucan-rich barley flour was produced in the mini-press and the laboratory extruder and then dried at low, medium and high temperature regimes. Colour, cooking quality and microstructure of the enriched pasta were investigated to determine its acceptability. The research showed that barley-enriched pasta of good cooking quality might be produced by selecting an optimal combination of suitable production parameters for forming and drying.
Genetic identification of bovine leukaemia virus
Authors: Donnik Irina , Donnik Irina , Vafin Ramil , Vafin Ramil , Galstyan Aram , Galstyan Aram , Krivonogova Anna , Krivonogova Anna , Shaeva Aigul , Shaeva Aigul , Gilmanov Khamid , Gilmanov Khamid , Karimova Rufiya , Karimova Rufiya , Tyulkin Sergey , Tyulkin Sergey , Kuźmak Jacek , Kuźmak Jacek
Published: December 2018

Molecular genetic research methods make it possible to evaluate the genetic diversity of bovine leukemia virus (BLV) and are the most informative approaches to its genetic identification. Molecular genetic research methods work well for the phylogenetic analysis of sequenced nucleotide DNA sequences of the provirus, as well as for the polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) according to the phylogenetic classification of the pathogen. The purpose of the research was to study the scientific and methodological approaches to the genetic identification of bovine leukemia virus, integrated into the molecular monitoring of infection of cattle with BLV genotypes. The authors used PCR-RFLP-genotyping and comparative phylogenetic analysis of aligned nucleotide sequences of the env gene fragment of the BLV provirus isolates to detect the genotypic affiliation of the cattle from twenty-one livestock farms of the Republic of Tatarstan. As a result, isolates of four out of ten BLV genotypes were found in the Tatarstani cattle, namely genotypes 1, 4, 7, and 8. The research involved a comparative analysis of 505 nucleotide sequences of a fragment of the BLV env gene, including those deposited in GenBank NCBI. The analysis confirms the inconsistency of several earlier PCR-RFLP typing strategies with the current approach in assessing the genotypic diversity by phylogenetic analysis. The improved strategy of PCR-RFLP genotyping of BLV corresponds with its modern phylogenetic classification. The strategy makes it possible to identify all the known genotypes of the viral pathogen. Its validity has been proved by in silico modelling of restrictogrammes and a phylogenetic analysis of the env gene fragment of 57 reference isolates of ten BLV genotypes that generate 57 genotype-associated combinations of diagnostically significant PCR-RFLP profiles.
Dynamics of acousto-convective drying of sunflower cake compared with drying by a traditional thermo-convective method
Authors: Zhilin Aleksandr , Zhilin Aleksandr , Fedorov Aleksandr , Fedorov Aleksandr , Grebenshchikov Dmitry , Grebenshchikov Dmitry
Published: December 2018

The article is devoted to the dynamics of sunflower cake drying in a fundamentally new acousto-convective way. Unlike the traditional (thermo-convective) method, the method proposed allows extracting moisture from porous materials without supplying heat to the sample. Thermo-vacuum drying helped to determine the absolute and relative initial moisture for the analysed samples of the sunflower cake, which equaled 313.1% and 75.8%, respectively. The kinetic curves for drying by thermo- and acousto-convective methods were obtained and analysed. A study of the acousto-convective drying of sunflower cake showed that the rate of moisture extraction depended on the resonating frequency, while there is an optimal mode in which drying proceeds from two to three times more intensively. In thermo-convective drying of sunflower cake, increasing the temperature of the drying stream twice (from 74.2°C to 127°C) reduces the duration of drying to a final absolute humidity of 40% three times. Comparing the thermo-convective and acousto-convective drying methods showed that twice as much moisture was removed from the samples dried by the (ACDP) with a flow frequency of 790 Hz and at room temperature for a 30-minute interval as with thermal convective drying with a working flow temperature of 127°C. The relaxation mathematical model used to describe the drying phenomenon and the experimental data for sunflower cake drying allows obtaining the quantitative parameters characterizing different modes and methods of drying the samples under study. The article analyses a discrete drying regime that contributes to increasing the efficiency of the acousto-convective mode of moisture extraction.
Natural sweeteners: health benefits of stevia
Authors: Gandhi Sukhmani , Gandhi Sukhmani , Gat Yogesh , Gat Yogesh , Arya Shalini , Arya Shalini , Kumar Vikas , Kumar Vikas , Panghal Anil , Panghal Anil , Kumar Ashwani , Kumar Ashwani
Published: December 2018

Stevia rebaudiana (Bertoni), a perennial shrub, is the sweetest plant belonging to the Asteraceae family. Stevia leaves are an excellent source of diterpene glycosides stevioside, rebaudioside A-F, dulcoside, and steviolbioside, which are responsible for sweetness and have been utilized commercially for sugar substitution in foods, beverages, and medicines. To the best of our knowledge, a large number of studies have been carried out on composition, health implications, and safety of steviol glycosides. However, commercial production of stevia-incorporated food products needs further research in order to meet the huge global demand. Stevia-incorporated products possess better sweetening potency and maximum consumer acceptability, when compared with other sugar substitutes. Hence, the current research attempts to review the health promoting effects of stevia with special emphasis on its application in the food system. The paper majorly features 1) the anti-hyperglycemic, anti-hypertensive, anti-caries, anti-inflammatory, and anti-cancer benefits of stevia, 2) value-added stevia-incorporated products, e.g. bakery, dairy, and beverages, 3) the effect of incorporation of stevia on physicochemical, rheological, and nutritional food properties, 4) the current status and regulatory perspective of utilizing stevia at national and international level. Due to legislative actions and growing consumer awareness, public interest in natural sweeteners has significantly increased. Since the use of artificial sweetener has recently been questioned, the data the present article provides will be useful for consumers and manufacturers that seek an alternative.
Sport nutrition: the role of macronutrients and minerals in endurance exercises
Authors: Valenta Rudolf , Valenta Rudolf , Dorofeeva Yulia , Dorofeeva Yulia
Published: December 2018

Athletes’ nutrition optimization is very important for the nutritional support in all sport specializations. Macronutrients, as well as minerals and vitamins, are functionally active components that play an important role in nutrition of athletes especially in endurance sport. Optimal use of diets, including specialized sport nutrition, normalizes biochemical, immune, endocrine functions and restores athletes’ energy balance at different stages of sport exercises. Non-optimal athletes’ nutrition of different age groups, inadequate to their physiological needs, and no personalized approach to athletes’ diets, violate their right to adequate safe nutrition, according to international standards and criteria. Nutritional factors are one of the most important key factors in the risk prevention measures for a large number of diet-dependent diseases (e.g. digestive, liver, pancreas, cardiovascular system, endocrine system, and kidney diseases). The review presents the information on energy requirements, balance and availability, types and content of functional products for athletes. It also gives an overview of the specialized food market in Russia.
Oxidative stability of edible oils via addition of pomegranate and orange peel extracts
Authors: Abd-Allah Islam , Abd-Allah Islam , Rabie Mohamed , Rabie Mohamed , Sulieman Abdelrahman , Sulieman Abdelrahman , Mostfa Dalia , Mostfa Dalia , El-Badawi Ahmed , El-Badawi Ahmed
Published: December 2018

The main objective of the present study was to improve the oxidative stability of sunflower oil (SFO) and soybean oil (SBO). The aqueous ethanol extracts (80% ethanol) of pomegranate and Baladi orange peels were used as natural antioxidants at concentrations of 800 and 1,200 ppm in SFO and SBO in comparison to butylated hydroxytoluene (BHT). Their antioxidant activities were estimated via the Rancimat method and over 24 days of storage at 65°C. The effect of extracts on the stability of sunflower and soybean oils during the storage period was studied by measuring the peroxide value (PV), conjugated dienes (CD) at 232 nm, conjugated trienes (CT) at 270 nm, free fatty acids (FFAs), iodine value (IV), and the refractive index (RI). A great difference in PVs was observed between the control sample and the oil samples containing natural extracts which slowed the rate of peroxide formation. Generally, the results showed that during the storage period at 65°C, the conjugated diene formation followed a similar pattern relative to PV accumulation. The PV, CD, CT, FFA, and RI values of SFO and SBO containing a pomegranate peel extract (PPE) and Baladi orange peel extract (BOPE) at concentrations of 800 and 1,200 ppm were lower than those of SFO and SBO containing 200 ppm BHT, and this trend became apparent during the storage period. The rate of reduction of IV in the control was higher than that in SFO and SBO containing both synthetic and natural antioxidants. These findings confirmed that the natural antioxidants under investigation could be used as alternatives to synthetic antioxidants to improve the oxidative stability of edible oils in the food industry.
Criteria for standartization of probiotic components in functional food products
Authors: Sukhikh Andrey , Sukhikh Andrey , Zakharova Yuliya , Zakharova Yuliya , Yuzhalin Arseniy , Yuzhalin Arseniy , Bykov Anatoliy , Bykov Anatoliy , Kotova Tatʹyana , Kotova Tatʹyana , Poznyakovskiy Valeriy , Poznyakovskiy Valeriy
Published: December 2018

The increasing volume of consumption of probiotics and functional food products requires determination of standardized criteria for cultures and their exometabolites used in functional products manufacturing. The study was aimed at developing criteria for the estimation and standardization of exometabolites and the colony-forming ability of probiotic strains for functional food production. The work included such microbiological and physicochemical methods as GC-MS, GPC, UV, and FT-IR-spectroscopy. Based on the results of the study, the comparative analysis of the microbiological properties of probiotic Bifidobacterium strains was provided, the fatty acid composition of the cell wall was described, and the physical and chemical study of the exopolymers produced by them was carried out. According to the data of FT-IR- spectroscopy, the characteristic features of the components of the cell wall of Bifidobacterium strains were established. Bifidobacteria form the unique composition of organophosphorus structures of lipoteichoic acids, which determines the adhesive ability of strains. The authors studied the molecular weight distribution of the samples of exometabolites isolated from the nutrient medium after the cultivation of bifidobacteria, under conditions of gel-permeation chromatography. The spectral (UV, FT-IR) characteristics of the produced metabolites and their chromatographic fractions were compared. The fatty acids of the Bifidobacterium cell membrane were analyzed using the GC/MS method. The fatty acids were extracted from bacterial cells with different hydrophobicity with a mixture of chloroform and hexane. It has been established that the hydrophobicity is determined by different contents of unsaturated and branched fatty acids in the bacterial membrane. Hydrophobic bifidobacteria are the only that contain the isopentadecane (isoC15:0) and methyl-tetradecanoic (13Me-C14:0) acids. With the mean hydrophobicity, a high content of the isopalmitic (isoC16:0) and stearic (C18:0) acids was established. Low-hydrophobic strains are characterized by a low content of monounsaturated fatty acids.
Occurrence of free-living amoebae (Acanthamoeba, Balamuthia, Naegleria) in water samples in Peninsular Malaysia
Authors: Gabriel Shobana , Khan Naveed Ahmed , Siddiqui Ruqaiyyah
Published: December 2018

The aim of this study was to determine the occurrence of free-living amoebae (FLA) in Peninsular Malaysia and to compare different methodologies to detect them from water samples. Water samples were collected from tap water, recreational places, water dispensers, filtered water, etc. and tested for FLA using both cultivation and polymerase chain reaction (PCR) via plating assays and centrifugation methods. Amoebae DNA was extracted using Instagene matrix and PCR was performed using genus-specific primers. Of 250 samples, 142 (56.8%) samples were positive for presence of amoebae, while 108 (43.2%) were negative. Recreational water showed higher prevalence of amoebae than tap water. PCR for the plating assays revealed the presence of Acanthamoeba in 91 (64%) samples and Naegleria in 99 (70%) of samples analysed. All samples tested were negative for B. mandrillaris. In contrast, the centrifugation method was less effective in detecting amoebae as only one sample revealed the presence of Acanthamoeba and 52 (29%) samples were positive for Naegleria. PCR assays were specific and sensitive, detecting as few as 10 cells. These findings show the vast distribution and presence of FLA in all 11 states of Peninsular Malaysia. Further studies could determine the possible presence of pathogenic species and strains of free-living amoebae in public water supplies in Malaysia.
Сollapse of weakly-nonspherical cavitation bubble in acetone and tetradecane
Authors: Toporkov D.Yu.
Published: December 2018

Collapse of a weakly-spherical cavitation bubble in acetone and tetradecane is studied. The bubble radius is 500 μm, the temperature and pressure of the liquid are 293 K and 15 bar in the case of acetone and 663 K and 50 bar in the case of tetradecane. A hydrodynamic model is used in which the compressibility of the liquid, the nonstationary thermal conduction of the vapor and the liquid, and nonequilibrium heat and mass transfer on the bubble surface, as well as imperfection of the vapor, are considered. Realistic wide-range equations of state are used. It has been found that converging shock waves appear in the bubbles during its collapses in acetone and tetradecane. The maximum values of the thermodynamic parameters are comparable. A comparison of the evolution of the bubble sphericity perturbation and motion of the shock wave in the bubble allows suggesting that tetradecane is a more favorable medium for the realization of a near-spherical cumulation in a bubble than acetone.
Recent Progresses in Organic-Inorganic Nano Technological Platforms for Cancer Therapeutics
Authors: Kumar Sanjay , Singhal Anchal , Narang Uma , Mishra Sweta , Kumari Pratibha
Published: December 2018

Nanotechnology offers promising tools in interdisciplinary research areas and getting an
upsurge of interest in cancer therapeutics. Organic nanomaterials and inorganic nanomaterials bring
revolutionary advancement in cancer eradication process. Oncology is achieving new heights under
nano technological platform by expediting chemotherapy, radiotherapy, photo thermodynamic therapy,
bio imaging and gene therapy. Various nanovectors have been developed for targeted therapy
which acts as “Nano-bullets” for tumor cells selectively. Recently combinational therapies are catching
more attention due to their enhanced effect leading towards the use of combined organicinorganic
nano platforms. The current review covers organic, inorganic and their hybrid nanomaterials
for various therapeutic action. The technological aspect of this review emphasizes on the use of
inorganic-organic hybrids and combinational therapies for better results and also explores the future
opportunities in this field.
An Update on Novel Antiplatelets in Vascular Patients
Authors: Patelis Nikolaos , Kakavia Kyriaki , Maltezos Konstantinos , Damaskos Christos , Spartalis Eleftherios , Matheiken Sean , Georgopoulos Sotirios
Published: December 2018

Background:

Acetylsalicylic acid, clopidogrel and cilostazol are well-established agents inhibiting the
normal function of platelets with known advantages and limitations. The development of novel antiplatelet agents
aims to provide equal or superior outcomes for patients and simultaneously minimize side effects.

Objective:

The aim of this manuscript is to review the latest data on the use of novel antiplatelet agents in vascular
patients.

Method:

Based on our 2016 review, a further search in the English medical literature has yielded a number of
publications on cangrelor, prasugrel, ticagrelor, vorapaxar and a number of other – still experimental – agents (Ir-
6, UBO-QIC, W1, revacept and YM-254890).

Results:

Recently published data have not altered the use and indications of cangrelor, prasugrel and vorapaxar;
all of them now approved by both FDA and EMA. The EUCLID trial has recently provided valuable data on the
clinical use of ticagrelor, although results regarding vascular patients and administration of ticagrelor are still
under scrutiny. Vorapaxar remains the only novel antiplatelet that is approved for PAD. Randomized control
trials that focus on vascular patients are necessary to establish the safety and efficacy of these novel agents. Despite
their positive initial results, most novel experimental antiplatelets are still in early development, thus in preclinical
or early clinical phases of their trials. Research on three novel antiplatelets is currently discontinued (atopaxar,
darexaban and elinogrel).

Conclusion:

Vorapaxar remains the only novel antiplatelet that is approved for PAD. Other novel antiplatelets
demonstrate positive results, but further studies focused on vascular patients are necessary. Novel experimental
antiplatelets are still in the early phases of the clinical and preclinical studies.
Novel Oral Anticoagulants in Peripheral Artery Disease: Current Evidence
Authors: Koutsoumpelis A. , Argyriou C. , Tasopoulou K.M. , Georgakarakos E.I. , Georgiadis G.S.
Published: December 2018

Background:

Peripheral artery disease is a common manifestation of systemic atherosclerosis which
strongly correlates to cardiovascular morbidity and mortality. In addition, the progression of peripheral artery
disease leads to an increased risk of limb loss. In order to reduce these events, the benchmark of treatment and
research over the last years has been the antiplatelet therapy which aims at inhibition of platelet aggregation. Over
the last years, new studies combining antiplatelet agents in different therapeutic schemes have been proven efficacious.
Unfortunately, patients remain still at high risk of CV events. Novel Oral Anticoagulants have been
introduced as alternatives to warfarin, in the prevention and treatment of venous thromboembolism. The rationale
of using medication which acts on platelet activation and the coagulation pathway of thrombosis has led investigators
to examine the role of Noac's in preventing CV events in patients with peripheral artery disease, stable or
unstable.

Methods:

The aim of this study is to review the current evidence with respect to recently published studies concerning
the use of Novel anticoagulants in peripheral artery disease.

Results:

The Compass trial has shown that a combination of rivaroxaban with traditional therapy may produce
promising results in reducing amputation rates, stroke, cardiac events, and mortality, however, there are still
safety issues with bleeding requiring acute care. The ePAD study has provided us with insight concerning safety
and efficacy after peripheral angioplasty or stenting and actually the need for further research. The Voyager Pad
study, following the steps of Compass, is studying the effect and safety of the addition of rivaroxaban to traditional
therapy in the highest risk population aka patients undergoing peripheral revascularization. The evidence
concerning patients with concomitant atrial fibrillation appears to be insufficient, however, recent guidelines
propose the use of novel oral anticoagulants.

Conclusion:

For the time being, novel oral anticoagulants in combination with aspirin may provide an alternative
treatment in PAD, however, it is deemed necessary to identify patient subgroups who will benefit the most.
Perioperative Management of DOACs in Vascular Surgery: A Practical Approach
Authors: Kouvelos George , Matsagkas Miltiadis , Rousas Nikolaos , Nana Petroula , Mpatzalexis Konstantinos , Stamoulis Konstantinos , Giannoukas Athanasios , Arnaoutoglou Eleni
Published: December 2018

Background:

Approximately 10–15% of patients on DOACs have to interrupt their anticoagulant
before an invasive procedure every year. The perioperative management and monitoring of DOACs have proved
to be challenging, as differences in patients’ status and in the invasiveness of each procedure develop different
situations that need a tailored therapeutic approach to each patient’s needs.

Methods:

This review aims to summarize current evidence on the perioperative management of DOACs in patients
undergoing a vascular surgical procedure focusing with a practical approach on three key clinical questions:
(i) can we stop DOAC therapy before the vascular procedure? (ii) is bridging therapy necessary? and (iii) which is
the best perioperative strategy for interruption and resumption of the anticoagulant therapy?

Results:

No specific data exist for the perioperative management of vascular surgery patients on DOACs, as most
studies include low number of such patients. Therapeutic strategy on how to handle DOACs perioperatively must
be based on their half-life, the bleeding risk of the invasive procedures, and on the thromboembolic risk of the
patient. Renal function plays a crucial role in such situations, increasing thromboembolic and bleeding risk. In
general, DOACs should be stopped 2 days for high bleed risk, 1 day for low risk and should be resumed 48-72 hrs
after high risk, 24 hrs after low-risk procedure. Bridging is almost never needed.

Conclusion:

Further perioperative research studies on patients undergoing vascular surgery are needed to confirm
whether currently accepted therapeutic perioperative strategy is appropriate for these patients.
Influence of Resveratrol on Sphingolipid Metabolism in Hepatocellular Carcinoma Cells in Lipid Overload State
Authors: Charytoniuk Tomasz , Harasim-Symbor Ewa , Polak Agnieszka , Drygalski Krzysztof , Berk Klaudia , Chabowski Adrian , Konstantynowicz-Nowicka Karolina
Published: December 2018

Background:

Obesity is characterized by increased long chain fatty acids (LCFA) uptake and impaired lipid metabolism in hepatocytes. Consequently, an enhanced intracellular lipid content, including sphingolipids, may lead to lipotoxicity. It is believed that resveratrol (RSV), one of the most extensively studied plant-derived polyphenols, and its interaction with sphingolipid metabolism may constitute one of the major therapeutic targets for cancer and metabolic diseases treatment.

Objective:

The aim of this study was to ascertain, whether resveratrol may affect sphingolipid metabolic pathways, enzymes and transporters in a lipid overload state.

Methods:

The experiments were conducted on hepatocellular carcinoma cells (HepG2) incubated with RSV and/or Palmitic Acid (PA) at the concentration of 0.5 mM and 50 µM, respectively for 16h. Intra- and extracellular sphingolipid concentrations were assessed by high-performance liquid chromatography and gas liquid chromatography. Moreover, the expression of caspase 3, selected fatty acid transporters and sphingolipid metabolism pathway proteins were estimated by Western Blot.

Results:

RSV alone and together with PA significantly increased the intracellular concentration of ceramide, sphinganine and sphingosine as well as the expression of enzymes related to de novo ceramide synthesis pathway. Moreover, in our study, we observed augmented ceramide and sphingomyelin efflux into the incubation media in these groups. In addition, RSV substantially reduced intracellular triacylglycerols accumulation in lipid overload conditions.

Conclusion:

The above-mentioned findings suggest that RSV, at least partially, demonstrates a potential protective effect on HepG2 cells in a lipid overload state.
Age at First Osteoporosis Screening Among Older Women and Men: Is Bone Mineral Density Measurement Ordered Timely?
Authors: Tasci Ilker , Basgoz Bilgin Bahadir , Cintosun Umit , Safer Umut , Naharci Mehmet Ilkin
Published: December 2018

Background:

US National Osteoporosis Foundation has specified age cut-offs for osteoporosis
screening in older women and men.

Objective:

In this study, we investigated whether Turkish seniors undergo their first ever osteoporosis
screening early, on time or late.

Methods:

We determined the age of older women and men at their first-time Bone Mass Densitometry
(BMD) testing using the medical records of a geriatric outpatient unit. The timing of the BMD test was
considered ‘’late’’ when performed after the age of 65 and 70 in women and men, respectively. An
“early” screening was defined as having a BMD measurement before these age cut-offs.

Results:

We included 481 individuals in the study (mean age: 74.5±6.5 years, women: 62%). On admission,
around 18% of the sample could give no definite information and another 35% had never been
assessed for osteoporosis. Among those with a past screening, 64.8% reported comorbid osteoporosis
and 33% reported no osteoporosis. Mean age of the first-time BMD measurement was 67.4±7.7 years.
The first-time BMD measurement was on time in 9.7%, early in 37.4% and late in 52.9% of the subjects.
Half of the individuals with a self-reported osteoporosis diagnosis were non-osteoporotic on a
new BMD ordered following the geriatric assessment. Multimorbidity (≥3), parental hip fracture, and
smoking were the independent predictors of being early screened.

Conclusion:

We found two-thirds of women and men unscreened for osteoporosis despite being indicated
by age. Early and late screening were both prevalent. Self-reported osteoporosis diagnosis was
mostly inconsistent with BMD testing in our sample.
Importance and Significance of Knee-Chest Decubitus Position of the Pregnant Women, in the Delineation of Fetal Facial Imaging with Four-Dimensional Color Doppler Ultrasound
Authors: Roy Homagni Sikha , Cheng Chunxia
Published: December 2018

Objective:

To investigate and validate the role of the Knee-chest Decubitus position in fetal facial feature delineation by 4D Ultrasonography.

Methods:

Pregnant women were randomly divided into two groups: One group underwent knee-chest decubitus position prior to re-examination, and the second group underwent free activities like walking for 5, 15 or 30 minutes followed by a re-examination of the fetus. The acceptability of the fetal facial images following the two above mentioned activities was compared.

Results:

The Knee-chest Decubitus position was identified to be a more successful procedure for obtaining acceptable images. Additionally, it improved the fetal position and the resulting images were achieved significantly rapidly by this maneuver compared to free movement.

Conclusion:

The knee-chest decubitus position is simple, easy, safe and fast and thus of great convenience and promising for pregnant women.
Anuvaadika: Implementation of Sanskrit to Hindi Translation Tool Using Rule-Based Approach
Authors: Agrawal Prateek , Jain Leena
Published: December 2018

Background:

Sanskrit is claimed as the second oldest language of the world and in ancient
days, Sanskrit was considered as mother tongue in the larger part of India. But now, it is struggling
for its acceptance in common people.

Objective:

Objective of the work is to develop algorithms for stemming of Sanskrit words, implement
semantic analysis, discourse integration and pragmatic analysis. Another objective is to implement
a translation tool that is able to translate Sanskrit text into Hindi.

Results:

Rule Based Method is used to prepare the corpora and implement the proposed work.
Results: An interface is made available through which step by step translation can be seen and understood.

Conclusion:

This tool will be helpful to those who are familiar in Hindi language but unable to learn
Sanskrit due to the scarcity of language experts. More than 60 million people from India and abroad
who are active Hindi users and work on computer, can get themselves connected with Sanskrit and
also can learn the Sanskrit fundamentals by self.
RELATIONSHIP OF ORGANIZATIONAL COMMITMENT WITH PATIENT SAFETY INCIDENT REPORT CULTURE
Authors: Harsul Wahyuni , Irwan Andi Masyitha , Sjattar Elly Lilianty
Published: December 2018

Patient Safety Incident Report is one of indicator that has an important role in supporting the quality of patient safety. Because, Patient Safety Incident report can identify and reducing risks to patients who are harmed by treatment. One of the seven steps to achieving patient safety is organizational commitment. Organizational commitment is a commitment should be owned by the nurse in helping hospitals to achieve patient safety goals by involving themselves as evidence of loyalty to the organization in terms of patient safety incident report. This study aimed to find out the relationship between organizational commitment and the culture of Patient Safety Incident report of nurses in hospitals. The research design used was descriptive analytic correlation with cross sectional approach. The number of samples was 100 people. Data were analyzed using the chi-square test. Organizational commitment related significantly on patient safety incident report, p = 0.039. Nurses who have goodÂ  organizational commitment have a high patient safety incident report 9%. Increasing organizational commitment owned by nurses can support the quality improvements, especially in the patient safety incident report. Giving rewards can be the alternative in increasing organizational commitment owned by nurses.
TRAFİK KAZA DESENLERİNİN TANIMLANMASINDA K-MEANS KÜMELEME ALGORİTMASININ KULLANILMASI: SAKARYA İLİ UYGULAMASI
Authors: GÜNER Samet , SEÇKİN CODAL Keziban , GEÇER Hüseyin Serdar , COŞKUN Erman
Published: December 2018

Amaç: Trafik
kazaları hem dünyada hem de ülkemizde can ve mal kayıplarına neden olmaktadır.
Sakarya ilinde meydana gelen trafik kazalarının incelendiği bu çalışmada,
şehirde meydana gelen trafik kazaları arasındaki benzerlik ilişkileri
araştırılmış ve bu benzerlik ilişkisinden yola çıkarak belli başlı kaza
karakteristikleri belirlenmiştir. Böylelikle, benzer kaza gruplarının
belirlenmesi ve bunlara özgü çözüm önerileri getirilmesi amaçlanmaktadır.  Yöntem: Trafik
kazalarının analizinde K-means kümeleme yöntemi kullanılmıştır. Bu yöntem,
birimleri benzer özelliklerine göre bir araya getirirken, farklı özelliklerine
göre de uzaklaştırmaktadır.  Bulgular: Kümeleme
analizi sonucunda, çevresel özellikler bağlamında Sakarya iline özgü dört
farklı kaza türü olduğu tespit edilmiş ve bu kaza türleri detaylı olarak
tanımlanmıştır.  Sakarya genelinde en
tipik kazaların kavşağın olmadığı yerlerde, kuru zeminde, açık havada, sonbahar
mevsiminde, hafta içi ve öğleden önce gerçekleştiği belirlenmiştir. Ayrıca,
analize dâhil olan Adapazarı, Erenler, Serdivan ve Arifiye ilçeleri için de
tipik kaza karakteristikleri tanımlanmıştır.

Sonuç: Araştırma
sonuçları, Sakarya’da meydana gelen trafik kazalarının temel
karakteristiklerini ortaya koymuştur. Böylelikle, araştırmanın trafik kazalarının
önlenmesinde ve azaltılmasında karar vericilere yardımcı olması beklenmektedir.
İŞE YABANCILAŞMA BOYUTLARININ DEMOGRAFİK DEĞİŞKENLER AÇISINDAN İNCELENMESİ
Authors: AKŞİT AŞIK Nuran
Published: December 2018

Amaç: Bu çalışmanın
amacı, otel çalışanlarının işe yabancılaşma boyutlarının demografik faktörlere
göre farklılık gösterip göstermediğinin belirlenmesidir.Yöntem: Araştırmanın evrenini, Ayvalık’ta faaliyet gösteren
otellerin çalışanları oluşturmaktadır. Araştırmada veri toplamak için, nicel
araştırma yöntemlerinden anket tekniğinden yararlanılmış olup, kolayda
örnekleme yoluyla seçilen 345 otel çalışanından veri toplanmıştır.  Çalışanların işe yabancılaşma
boyutlarını ölçmek amacıyla, Seeman (1983) tarafından geliştirilen işe
yabancılaşma ölçeği kullanılmıştır. Araştırmadan elde edilen veriler,
betimsel istatistikler, Mann Whitney U testi ve Kruskal Wallis-H testleri ile kullanılarak analiz edilmiştir.
Bulgular: Araştırma
bulguları, çalışanların işe yabancılaşma düzeylerinin ortalamaya yakın
olduğunu, en fazla yalıtılmışlık, en az güçsüzlük boyutunda yabancılaşma
yaşadıklarını göstermektedir. Araştırma bulgularına göre, anlamsızlık boyutunda
çalışanların cinsiyeti, anlamlı bir fark yaratmaktadır. Ayrıca, eğitim durumu
güçsüzlük boyutunda, yaş ve çalıştığı bölüm kendine yabancılaşma boyutu
üzerinde anlamlı bir fark oluşturmaktadır. Çalışma süresi, güçsüzlük,
kuralsızlık, yalıtılmışlık ve kendine yabancılaşma boyutları üzerinde etkili
olurken, otelin sınıfı güçsüzlük ve yalıtılmışlık boyutlarında etkilidir.
Bununla birlikte çalışanların medeni durumu, işe yabancılaşmanın boyutları
açısından anlamlı bir farklılık yaratmamaktadır.

Sonuç: Araştırma sonuçlarına göre,
yabancılaşma boyutları çalışanların bazı demografik özelliklerine göre
istatistiksel olarak anlamlı farklılık göstermektedir.
FİRMALARIN AR-GE HARCAMALARININ AKTİF VE ÖZSERMAYE KARLILIĞINA ETKİSİ: BİST TEKNOLOJİ SEKTÖRÜNDE BİR UYGULAMA
Authors: YILDIRIM Hasan Hüseyin , SAKARYA Şakir
Published: December 2018

Amaç: Ar-Ge ve
yenilik günümüz rekabet dünyasında, firmaların performanslarını arttırmak ve
büyümek için en çok ihtiyaç duyduğu unsurların başında gelmektedir.  OECD
ülkelerinin Ar-Ge harcamaları ile karşılaştırıldığında Türkiye’deki Ar-Ge payı
az da olsa yıllar itibarıyla artış göstermektedir. Yenilikçi hizmet ve
ürünlerin üretilmesini mümkün kılan Ar-Ge yatırımları firmalara uzun dönemli
rekabet avantajı ve büyüme sağlayan ve değer yaratan faaliyetlerdir. Bu
çalışmanın amacı, önemi her geçen gün biraz daha artan Ar-Ge harcamalarının
firmaların finansal performansına etkisini araştırmaktır.Yöntem: Bu amaçla
BIST teknoloji ve bilişim sektöründe faaliyet gösteren firmaların Ar-Ge
harcamalarının aktif karlılığına(ROA) ve öz sermaye karlılığına (ROE) etkisi
panel veri analizi ile test edilmiştir.Bulgular: Analiz
sonuçlarına göre Ar-Ge harcamaları ile hem ROA hem de ROE arasında uzun dönemde
nedensellik ilişkisinin var olduğu tespit edilmiştir. Ar-Ge harcamalarından ROA
ve ROE’ye tek yönlü bir nedenselliğin olduğu tespit edilmiştir. Nedensellik
sonucundan sonra yapılan regresyon analizinde Ar-Ge harcamasının ROA ve ROE’de
anlamlı ve pozitif bir etkisinin olduğu sonucuna ulaşılmıştır.

Sonuç: Ar-Ge
harcamalarının karlılığı pozitif yönde etkilediği düşünüldüğünde, işletmelerin
Ar-Ge’ye yönelik olarak yapacakları bugünkü yatırımlar gelecekte işletmelerin
çağa ayak uydurabilmesinde ve yoğun rekabet koşullarında ayakta kalabilmesine
yardımcı olacaktır.
Медикаментозна корекція ендотеліальної дисфункції в дітей із хронічним пієлонефритом
Authors: Vakulenko L.I.
Published: December 2018

Актуальність. Своєчасна й достатня медикаментозна корекція ендотеліальної дисфункції в дітей із хронічним пієлонефритом визначає ефективність запобігання його прогресуванню, покращення серцево-судинного й ниркового прогнозу. Мета: вивчення ефективності різних схем медикаментозної корекції ендотеліальної дисфункції в дітей із хронічним пієлонефритом. Матеріали та методи. Обстежено 37 дітей віком 11–17 років із хронічним пієлонефритом поза періодом загострення. Перша група (17 пацієнтів) отримувала базисну терапію хронічного пієлонефриту, що включала інгібітор ангіотензинперетворюючого ферменту (іАПФ) еналаприл; друга група (20 пацієнтів) крім стандартної терапії з іАПФ отримувала внутрішньовенну інфузію L-аргініну, а потім його пероральний розчин. Результати. У пацієнтів першої групи зареєстровано тенденцію до збільшення без вірогідної відмінності від стану до лікування значень діаметра плечової артерії в спокої (2,4 ± 0,1 мм), у фазу максимальної вазодилатації (2,9 ± 0,1 мм). Приріст діаметра плечової артерії після лікування вірогідно збільшився порівняно зі значенням до лікування (12,00 ± 0,39 мм). Лінійна швидкість кровотоку в стані спокою зменшувалась статистично незначуще (146,90 ± 1,13 см/с). У пацієнтів другої групи зареєстровано вірогідне збільшення порівняно з вихідним значенням діаметра плечової артерії в спокої (2,80 ± 0,13 мм) і у фазу максимальної вазодилатації (3,40 ± 0,14 мм). Приріст діаметра плечової артерії після лікування вірогідно не відрізнявся від фізіологічної норми (17,20 ± 0,41 мм). Лінійна швидкість кровотоку в стані спокою наближалась до значення в групі контролю без вірогідної різниці (141,20 ± 1,16 см/с). У цілому покращання функціо­нального стану ендотелію судин відбулося в групах на 26,9 і 47,8 % відповідно. Висновки. У хворих на хронічний пієлонефрит без проявів хронічної ниркової недостатності є ефективною монотерапія іАПФ еналаприлом. Для хворих, які мають прояви хронічної ниркової недостатності І–ІІ ступеня, доцільною є комбінована терапія з L-аргініном.
Рекурентні респіраторні інфекції в педіатричній практиці: ефективність застосування інозину пранобексу
Authors: Borysova T.P. , Badogina L.P. , Fedko Т.В.
Published: December 2018

В огляді літератури наведені сучасні дані щодо термінології та причини рекурентних респіраторних інфекцій у дітей, імунологічних основ рецидивування інфекцій респіраторного тракту в дитячому віці. Представлена схема стандартного обстеження дитини з рекурентними респіраторними інфекціями. Дана характеристика препарату інозин пранобекс із противірусною та імуномодулюючою дією. Узагальнено результати досліджень клінічної ефективності інозину пранобексу при рекурентних респіраторних інфекціях у дітей. Показані дозування і схеми застосування препарату інозин пранобекс при рекурентних респіраторних захворюваннях у дітей.
Показники ендотеліальної дисфункції при цукровому діабеті 2-го типу як визначальні чинники розвитку ускладнень
Authors: Ziablytsev S.V. , Chernobryvtsev O.P. , Ziablitsev D.S.
Published: December 2018

Актуальність. Для з’ясування патогенетичної ролі основних чинників, що відображають розвиток ендотеліальної дисфункції (ЕДФ), була зроблена спроба у рамках одного дослідження розрахувати їх вплив на розвиток судинних ускладнень цукрового діабету (ЦД) 2-го типу. До числа таких показників увійшли ендотелін-1 (ЕТ-1), фактор некрозу пухлини (TNF-α) та дієнові кон’югати (ДК). Також було обрано два захисні фактори — оксид азоту (NO) і ендотеліальна NO-синтаза (eNOS). Мета дослідження: вивчити вплив показників ЕДФ при ЦД 2-го типу на розвиток його ускладнень. Матеріали та методи. До дослідження залучено дані 152 хворих на ЦД 2-го типу, вік пацієнтів становив від 34 до 80 років, у середньому 53,9 ± 8,4 року. Жінок було 95 (62,5 %), чоловіків — 57 (37,5 %). Відповідно до клінічних рекомендацій, за результатами клініко-лабораторних обстежень визначали наявність ретинопатії, нефропатії за рівнями мікроальбумінурії та швидкості клубочкової фільтрації (ШКФ), сенсорної полінейропатії, макроангіопатії нижніх кінцівок та артеріальної гіпертензії. У плазмі крові імуноферментним і біохімічним методами визначали вміст чинників ЕДФ. Для математичної обробки отриманих даних використовували програму Statistica 10 (StatSoft, Inc., США), пакет GLZ. Результати. На наявність ретинопатії сильно впливав рівень у крові ЕТ-1 (β = 3,1; р = 2,77Е-05), а також TNF-α (β = 0,019; р = 0,050). На наявність макроангіопатії нижніх кінцівок — рівень в крові NO (β = 27,5; р = 0,021) і TNF-α (β = –0,48; р = 0,017). Для полінейропатії значущим виявився тільки один показник — ЕТ-1 (β = 1,8; р = 0,016). На наявність нефропатії за ШКФ впливали рівні у крові ЕТ-1 (β = 2,7; р = 7,58Е-07) і TNF-α (β = 0,013; р = 0,047). Розвитку нефропатії за мікроальбумінурією сприяв ЕТ-1 (β = 4,5; р = 0,043). На наявність артеріальної гіпертензії впливали ЕТ-1 (β = 1,69; р = 2,54Е-04) і TNF-α (β = 0,017; р = 0,014). Шляхом багатофакторної логістичної регресії побудовані моделі прогнозування ймовірності розвитку ускладнень ЦД 2-го типу на підставні вивчених чинників ЕДФ. Усі моделі адекватні і мають високий рівень прогностичної точності (60,5–90,8 %). Висновки. На розвиток ускладнень ЦД 2-го типу по-різному впливали чинники ЕДФ: ЕТ-1 безпосередньо впливав на розвиток усіх ускладнень (окрім макроангіопатії нижніх кінцівок); TNF-α здійснював вплив на розвиток ретинопатії, нефропатії за ШКФ і артеріальної гіпертензії; накопичення у крові NO сприяло розвитку макроангіопатії нижніх кінцівок.
Роль експресії гена Foxo1 у механізмі антигіпертрофічної дії метформіну в кардіоміоцитах
Authors: Pasiechko N.V. , Loi H.Ya. , Korda M.M. , Oleshchuk O.M.
Published: December 2018

Актуальність. Діабетична кардіоміопатія є провідною причиною смертності при цукровому діабеті (ЦД) 2-го типу. Однією з основних патоморфологічних ознак розвитку діабетичної кардіоміопатії розглядається гіпертрофія кардіоміоцитів. Метформін, засіб вибору першої лінії для лікування ЦД 2-го типу, окрім антигіперглікемізуючих, викликає кардіопротективні ефекти. Проте механізм дії препарату в кардіоміоцитах вивчений недостатньо. Мета. Вивчення ролі експресії гена Foxo1 у механізмі антигіпертрофічної дії метформіну в кардіоміоцитах. Матеріали та методи. Н9С2 клітини були трансфектовані за допомогою siRNA Foxo1 та siRNA negative control. Клітини були депривовані у 0% медіумі протягом 24 годин, за 30 хвилин до стресу проліковані метформіном (5 mM) і поміщені у гіпоксичний бокс на 16 годин із подальшою реоксигенацією протягом чотирьох годин. Площі клітин визначені за допомогою програми ImageJ. Ефективність трансфекції підтверджено за допомогою полімеразної ланцюгової реакції в реальному часі. Результати. При нормальному функціонуванні гена Fохо1 метформін проявляє виражену антигіпертрофічну дію в умовах гіпоксії. Проте блокування експресії Fохо1 позбавляє препарат цього ефекту і викликає гіпертрофію Н9С2 клітин у всіх умовах експерименту. Висновки. Виражена гіпертрофічна відповідь у групі клітин, трансфектованих за допомогою siRNA Foxo1, які культивувалися в умовах гіпоксії і були проліковані метформіном, може бути результатом одного з механізмів: а) метформін запобігає збільшенню розмірів клітин через Fохо1-залежний механізм, тому блокування гена Fохо1 призводить до втрати препаратом антигіпертрофічного ефекту; б) метформін захищає від гіпоксії незалежно від Fохо1-шляху, тому виражена гіпертрофія лікованих метформіном клітин, інкубованих у гіпоксії, є наслідком гальмування експресії Fохо1, що є потужним гіпертрофічним стимулом. Отже, з’ясування кардіопротективного механізму дії метформіну залишається надзвичайно актуальним питанням і потребує подальшого вивчення.
Самоменеджмент як технологія удосконалення організації діяльності лікаря загальної практики-сімейного лікаря
Authors: Voronenko Yu. V. , Shekera O. G. , Gorachuk V. V.
Published: December 2018

Мета дослідження полягала у обґрунтуванні науково-практичних підходів до удосконалення організації діяльності лікаря загальної практики-сімейного лікаря. Досягнення мети здійснювалось шляхом виконання завдань дослідження: адаптації технологій загального менеджменту організацій до технологій самоменеджменту лікаря загальної практики-сімейного лікаря та розробки рекомендацій для їх практичного застосування. Матеріали та методи. Аналізувалися нормативно-правові документи, джерела наукової літератури. Використовувалися методи системного підходу, системного аналізу, моделювання, графічний. Результати. Адаптація функцій загального менеджменту організацій до самоменеджменту діяльності лікаря загальної практики-сімейного лікаря дозволила розробити удосконалені підходи до: планування роботи за основними та допоміжними видами діяльності на основі принципів процесного підходу, самоорганізації діяльності –  з використанням технології тайм-менеджменту, координації діяльності – з урахуванням положень командного менеджменту, побудови комунікацій – на основі стрес-менеджменту. Обґрунтовані функції самоконтролю - шляхом здійснення постійного моніторингу власної діяльності та самомотивації до праці - через розуміння переваг перебування в професії, а також методи і засоби самоменеджменту. Запропоновано до впровадження в роботу лікаря загальної практики-сімейного лікаря розроблену модель самоменеджменту. Висновки. Удосконалення організації діяльності лікаря загальної практики-сімейного лікаря може бути забезпечено впровадженням технологій самоменеджменту, адаптованих з загального менеджменту до особливостей медичної практики при  наданні первинної медичної допомоги.