bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Efficacy of Antibiotics and PGF2α in the Treatment of Postpartum Endometritis in Nili-Ravi Buffaloes
Authors: Abid Ullah  , Rizwan Muhammad , Ali Amjad , Ahsan Raza Hafiz , Qadoos Abdul , Ambreen Nargis , Khan Imran , Khan Shahzeb , Livestock Safiullah , Khan Imtiaz , Khan Jahangir , Din Israr ud , Khan Yasir
Published: November 2024

This study compared the effects of ceftiofur HCL, oxytetracycline, and PGF2α on controlling postpartum endometritis and improving reproductive performance in Nili Ravi buffaloes. Sixty-two buffaloes with clinical endometritis were divided into five treatment groups. Group 1 (n=12) received intrauterine oxytetracycline; Group 2 (n=12) received oxytetracycline and PGF2α; Group 3 (n=12) received ceftiofur HCL; Group 4 (n=15) received ceftiofur HCL and PGF2α; and Group 5 (n=11) was the untreated control. Treatment success rates were 75%, 83.33%, 67.33%, 73.33%, and 45.5% in the respective groups. The control group had a significantly lower success rate (P ≤ 0.05). Days to first service were lowest in Group 2 (71.66±16.35). Days open were also significantly lower in Group 2 (106.75±14.66). First and second service conception rates were highest in Group 2 (58.33% and 83.33%). Services per pregnancy were lowest in Group 2 (1.8±0.74). Overall, Group 2 (oxytetracycline + PGF2α) showed better reproductive outcomes compared to the control. The study concluded that oxytetracycline combined with PGF2α improves postpartum reproductive performance in buffaloes.
Artificial Intelligence in Metabolomics for Disease Profiling: A Machine Learning Approach to Biomarker Discovery
Authors: Ahmad Qureshi Muhammad Danial , Ramzan Muhammad Fahid , Amjad Fatima , Haider Naeem
Published: November 2024

With an emphasis on the identification of biomarkers for pancreatic cancer, this research investigated the use of artificial intelligence (AI) and machine learning (ML) in metabolomics for disease profiling. With the use of the Kaggle dataset "Pancreatic Cancer Urine Biomarkers," which comprises 591 samples from diverse patient cohorts, we examined the connections between distinct proteome and metabolomic markers and their diagnostic value. Plasma CA19-9, LYVE1, REG1B, REG1A, and TFF1 were among the key biomarkers that were assessed in order to create a prediction model that could differentiate between benign cases, healthy controls, and pancreatic ductal adenocarcinoma (PDAC). According to our findings, the XGBoost classifier performed much better than conventional statistical techniques, recognizing positive instances with 89% accuracy and 91% sensitivity. The research also demonstrated the intricate relationships between several biomarkers that affect diagnostic accuracy and emphasized the crucial significance of the REG1B/REG1A ratio as a new predictor. We verified our model's robustness and generalisability across various patient demographics using a thorough validation procedure that included cross-validation and sensitivity analysis. "This work demonstrates how artificial intelligence can revolutionize metabolomics, opening the door to more accurate illness characterization and individualized treatment plans. In order to enhance early identification and outcomes of pancreatic cancer and other associated disorders, our results ultimately support the use of machine learning techniques into clinical practice.
Investigating the Impact of ERAS Protocols on Postoperative Outcome in Patients Undergoing Colorectal Surgery.
Authors: Bashir Maria , Nazir Ali Hifza , Mehmood Yasir , Fattani Bilal , Shafiq Pakeeza , Siddique Hira
Published: November 2024

Background: Enhanced Recovery After Surgery (ERAS) protocols have been increasingly adopted in colorectal surgery to improve postoperative outcomes.

Objective: This study investigates the impact of ERAS protocols on postoperative outcomes in patients undergoing colorectal surgery Methods: This is a cross-sectional study conducted on 60 consecutive patients undergoing colorectal surgery at Jinnah hospital from January 2024 to August 2024. The participants were divided into two groups with 30 participants each. Group I was treated as per ERAS protocol while Group II was given traditional care. Demographic data, mean operative time, Length of hospital stay, post operative pain and post operative complication was noted in both groups. Data was assessed on SPSS version 24.

Results: The mean operative time was notably shorter in Group I at 55.4 minutes compared to 64.7 minutes in Group II, (p-value=0.006). Post- operative pain, assessed via the Visual Analogue Scale, showed lower scores in Group I on all measured days: Day 1 (3.71 ± 0.97 vs. 4.69 ± 0.93, p = 0.033), Day 2 (2.32 ± 0.85 vs. 3.13 ± 0.95, p = 0.03), and Day

3 (1.49 ± 0.79 vs. 1.98 ± 0.98, p = 0.04) (Table 2). Additionally, Group I experienced a quicker return to oral intake (1.3 ± 0.4 days vs. 1.9 ± 0.7 days, p = 0.005) and mobilization (2.1 ± 0.9 days vs. 3.6 ± 1.1 days, p = 0.04).

Conclusion: This study highlights the significant advantages of implementing ERAS protocols in colorectal surgery, demonstrating improved postoperative outcomes, compared to traditional care.
PROPOSTA DE AJUSTE DA FUNÇÃO SIGMOIDAL E ÁREA TRINCADA DO MeDiNa USANDO DADOS DA GERÊNCIA DE PAVIMENTOS E DE SEGMENTOS EXPERIMENTAIS
Authors: Almeida Mario Sergio de Souza , Costa Weiner Gustavo Silva , Bressanin Hermes Wiliam , Wargha Filho Nelson , Mello Luiz Guilherme Rodrigues de
Published: November 2024

O lançamento do método mecanístico-empírico brasileiro pelo DNIT, em 2020, trouxe consigo o desafio de ajustá-lo para operacionalização, em substituição ao método empírico ainda vigente. O programa PRO-MeDiNa, embora robusto e adequado para vencer esse desafio, demanda tempo para geração de dados suficientes para viabilização do novo método. Dessa forma, o presente estudo apresenta uma proposta de ajuste da função sigmoidal utilizada como referência no MeDiNa, com auxílio do banco de dados do Sistema de Gerência de Pavimentos do DNIT (SGP), no qual 34 seções, com extensão de 1000 m cada, de 17 estados brasileiros, foram inventariadas, possibilitando determinar a evolução da área trincada (AT) entre os anos de 2013 e 2022. O comportamento desses segmentos em operação na malha viária federal possibilitou avaliar, de forma comparativa, a necessidade de ajuste da função sigmoidal do MeDiNa. Os resultados das análises demonstram que o atual formato da função sigmoidal não foi capaz de caracterizar devidamente o comportamento real dos pavimentos em operação, carecendo, portanto, de adequação. Entretanto, simulações com segmentos experimentais PRO-MeDiNa indicaram o nível de ajuste a ser realizado, de modo a garantir estimativas de AT consistentes e bem ajustadas aos comportamentos dos pavimentos asfálticos. A materialização do ajuste proposto no MeDiNa será facilitada com a introdução de uma correlação entre a AT da sigmoidal vigente e a nova, ora proposta, possibilitando que todos os cálculos no software continuem sendo efetuados da mesma forma, com apenas uma correção da AT ao final das simulações.
PROPOSTA DE UTILIZAÇÃO DE DADOS DE TRÁFEGO DO PNCT EM SEGMENTOS PRO-MeDiNa
Authors: Wargha Filho Nelson , Rosa Thiago Davi , Venâncio Junior Amaro , Souza Almeida Mario Sérgio de , Petisco de Souza Henrique
Published: November 2024

Nos segmentos experimentais do programa PRO-MeDiNa são levantadas, periodicamente, informações funcionais e estruturais, visando ao aperfeiçoamento da função de transferência do novo método de dimensionamento nacional de pavimentos asfálticos (MeDiNa). No sentido de complementar essas informações, são previstas contagens de tráfego com periodicidade anual. Essa tarefa pode ser realizada por meio de contagem manual, bem como por outras formas de avaliação: contagem automática por meio de vídeo registro simples, identificação automática de veículos ou outro processo automatizado. Para implementação dessas diferentes metodologias, há necessidade de contratação de empresa terceirizada por meio de processo licitatório específico. O Plano Nacional de Contagem de Tráfego (PNCT), vigente no DNIT, realiza contagem permanente, 365 dias por 24 horas e apresenta 90 % de probabilidade de o erro ser inferior a 5 %, tendo nível de confiança significativamente superior à da contagem convencional de 7 dias. Após testes em segmentos específicos, constatou-se a potencialidade do uso do PNCT nos segmentos experimentais. Para automatizar a organização e tratamento da extensa quantidade de informações geradas no PNCT, foi necessária a criação de uma rotina computacional. A ferramenta escolhida foi o Alteryx Designer que, através de nove sub-rotinas descritas neste estudo, mostrou-se promissora. Assim, propõe-se que essa rotina elaborada para os segmentos PRO-MeDiNa possa ser expandida e introduzida diretamente na saída dos dados do PNCT, permitindo o seu uso no planejamento e estudos de tráfego em toda a malha viária sob a jurisdição do DNIT.
MANEJO FLORESTAL DE PINUS NA FAIXA DE DOMÍNIO DA BR-282
Authors: Dos Santos Floriani Guilherme
Published: November 2024

O manejo florestal em faixas de domínio de rodovias é fundamental para conciliar os benefícios oferecidos pelas árvores e a busca por elevados padrões de segurança viária, como evidenciado na faixa de domínio da Rodovia Federal BR-282, localizado no Município de Rancho Queimado/SC. O inventário florestal estimou o volume de 3041,4 m³ de madeira de Pinus taeda L. e valor de mercado superior a R$ 700.000,00. Os povoamentos foram estratificados em 4 tipologias (renques, bosques, talhões e árvores isoladas). O Pinus conduzido em renques se destacou por ocupar 4,6 % da área da faixa de domínio do trecho de 26,5 km, apresentando uma feição estética singular e um notável resultado produtivo: 52 % do volume total de madeira e 72,6 % do valor de mercado. Contudo, o registro de acidentes com árvores mostra a necessidade de melhor coordenação na gestão rodoviária para integrar o manejo florestal com as ações voltadas à segurança viária.
Condições de trabalho docente na Licenciatura em Educação do Campo (LEdoC) do estado do Amapá (2014-2020)
Authors: Assunção Vanessa Lima dos Santos Assunção , Lobato Sidney da Silva
Published: November 2024

Este artigo analisa as condições de trabalho docente na Licenciatura em Educação do Campo (LEdoC) do Campus Mazagão da Universidade Federal do Amapá (Unifap). Nosso estudo aborda o período vai desde a implantação dessa LEdoC, em 2014, até o momento da suspensão de suas atividades presenciais, no início de 2020. O problema de investigação é o seguinte: quais eram as condições de trabalho docente na LEdoC durante seus primeiros anos de existência? O exame das referidas condições se deu por meio de entrevistas de história oral e de pesquisa documental. Os resultados evidenciam que o Estado, ao executar políticas educacionais para a LEdoC, não garantiu uma estrutura mínima ao Campus Mazagão e, em decorrência disso, o trabalho docente aí realizado foi precarizado e intensificado.
Palavras-chave: trabalho docente, condições de trabalho, educação do campo, Ledoc.
 
Working conditions teaching in the Degree in Rural Education (LEdoC) in the state of Amapá (2014-2020)
ABSTRACT. This article analyzes the working conditions of teachers in the Degree in Rural Education (LEdoC) at Campus Mazagão at the Federal University of Amapá (Unifap). Our study is scoped to the period since the implementation of this LEdoC, in 2014, until the moment of suspension of its face-to-face activities, in early 2020. The research problem is: what were the teaching working conditions at LEdoC, during its first years of existence? The examination of these conditions took place through oral history interviews and documentary research. The results show that the State, when executing educational policies for the LEdoC, did not guarantee a minimum structure to the Campus Mazagão and, as a result, the teaching work carried out there was precarious and intensified.
Keywords: teaching work, working conditions, rural education, Ledoc.
 
Condiciones laborales docencia en la Licenciatura en Educación Rural (LEdoC) en el estado de Amapá (2014-2020)
RESUMEN. Este artículo analiza las condiciones de trabajo de los docentes de la Licenciatura en Educación Rural (LEdoC) del Campus Mazagão de la Universidad Federal de Amapá (Unifap). Nuestro estudio se enmarca en el período desde la implementación de esta LEdoC, en 2014, hasta el momento de suspensión de sus actividades presenciales, a principios de 2020. El problema de investigación es el siguiente: ¿cuáles eran las condiciones de trabajo docente en la LEdoC, durante sus primeros años de existencia? El examen de estas condiciones se llevó a cabo a través de entrevistas de historia oral e investigación documental. Los resultados muestran que el Estado, al ejecutar las políticas educativas para la LEdoC, no garantizó una estructura mínima al Campus Mazagão y, en consecuencia, la labor docente allí desarrollada fue precaria e intensificada.
Palabras clave: trabajo docente, condiciones de trabajo, educación rural, LEdoC.
Dentoalveolar compensation assessment using PA cephalograms in orthodontic asymmetry patients
Authors: Nagib R. , Szuhanek C.
Published: November 2024

Asymmetry patients have various degrees of discrepancy between skeletal and dental relationships that are subject to the observation and correction of orthodontic or interdisciplinary teams of specialists. Dentoalveolar compensation is a system that helps maintain a state of occlusal balance in the maxillo-facial segment. Aim: The purpose of the present study is to assess the degree of dental compensation through dental midline shifting in patients with facial asymmetry. Material and Methods: 20 postero-anterior cephalograms of orthodontic patients with clinically visible facial asymmetry were studied using the Svanholt and Solow analysis. Results: Six of the patients included in this study presented both a maxillary and mandibular skeletal midline shift. Dentoalveolar compensation, defined by the shifting of the dental midlines was observed both in the upper and in the lower arch. Conclusion: Dentoalveolar compensation assessment is a necessary step of orthodontic diagnosis and treatment planning.
Quality of life evaluation of symptomatic TMJ patients during and after occlusal split therapy
Authors: Sirbu A. , Szuhanek C. , Lucaciu O. , Bordea R. , Feurdean C. , Campian R.S.
Published: November 2024

Objectives: Temporomandibular disorders is a pathology that involve temporomandibular joint and masticator muscle. Numerous studies showed that TMJ pain is the second most common chronic musculoskeletal condition after chronic low back pain. In patients with TMJ pathology splint are used very often to release the pain and to put the mandible in centric relation. Materials and methods: For evaluation of the impact of splint therapy in the patient’s quality of life we have investigated 26 adult patients. We decided to use the qualitative statistical approach to evaluate the changes in the patient’s quality of life, since it is a qualitative perception rather than a quantitative one. Results: We compute the mean value m1 of the patient’s evaluation at question number 1 at each appointment. This parameter allows as to check the progress of the treatment and consequently the improvement of patient condition. We noticed a significant improvement of symptomatology. Conclusion: Patients that experience moderate pain at the beginning of the treatment are wearing the splint for more than 16 hours per day (grade 7 average), and those with severe pain for more than 20 hours per day (grade 9average). The most important thing is that on 90% of these cases, with severe and moderate pain, the pain disappears completely after 8 weeks.
Evaluation of fluoride release into saliva after topical application: an in vitro experiment
Authors: Funieru C. , Oancea R. , Cărămidă M. , Sfeatcu R.
Published: November 2024

Fluoride is the most important element in caries prevention and control. Topical fluoride therapies, self-applied or professional procedures, are frequently used such as dentifrices, mouthwashes, varnished, gels etc. The most important thing for a topical fluoride therapy irrespective of type of substance, method, concentration or frequency of application is fluoride concentration in oral fluid or in dental plaque. This study is an in vitro experiment developed on extracted teeth. Teeth were fluoridated with tin fluoride gel (0.4%) after they were cleaned with an ultrasonic scaler, water and immersed in a hypochlorite solution for 10 minutes. Afterward, the concentration of fluoride released from the teeth enamel was measured at 24, 48, and 72 hours using HI-729 Fluoride Low Range Handheld Colorimeter device. The amount of fluoride released between 48 hours and 24 hours from fluoridation (0.22 – 0.37 ppm) was a higher than the one released between 72 and 48 hours from fluoridation (0.15 – 0.18 ppm). The amount of fluoride released from the teeth enamel decreases in time after the topical fluoridation.
Study of the influence of juice consumption and eating habits on children's teeth in Rieni, Bihor County
Authors: Porumb A. , Ratiu C. , Balint A.M. , Ciavoi G.
Published: November 2024

The present study included all preschool and school children from Rieni, Bihor County and their parents. The study aims to assess parents' knowledge of oro-dental health, as an integral part of general health, means of prevention and prophylaxis of tooth decay, as well as juice consumption and eating habits of children in Rieni, Bihor Country. As material and method, we proceeded to collect individual opinions, expressed by completing a questionnaire. In conclusion, slow consumption of acidic beverages over a long period of time, especially if drunk in small sips, can create dental erosion, induced by the action of acidic substances. Small amounts consumed between meals, will permanently provide food for cariogenic bacteria, will subject the teeth to long periods of demineralization and will therefore be at the origin of numerous carious processes.
Prophylaxis of dental diseases in the first period of mixed dentition
Authors: Cuc E.A. , Domocoș D. , Cuc G.D. , Todor P.C. , Bei M.F. , Anchidin O.I. , Pogan M.D.
Published: November 2024

Introduction: To reduce the morbidity caused by dental caries, it is necessary to intervene to eliminate it by acting on socio-economic, behavioural, environmental and medico-biological factors as well as on health systems. The aim of this study was to continue to promote oral health among pupils aged 6-9 years. Objectives-The study aimed at: - identifying the main aspects of dental morbidity specific to the first period of mixed dentition, studying the morbidity of the six-year molar due to caries. Material and method: The study group included 1st, 2nd and 3rd grade pupils because their age corresponds to the first period of mixed dentition: 6-9 years old. Results and discussions: Simple caries at the six-year molar are present in 35 of the cases (23.3%). The most affected are the lower molars (36 and 46) - 25 cases (16.6%), and in 10 cases (6.66%) all 4 permanent first molars are affected. One third of the subjects states that they regularly visit the dental office. Half of the children in the group go to the dentist only in case of emergency.
Comparative study on linear dimensional stability between condensation silicones and addition silicones using the sandwich technique
Authors: Brăilă E.B. , Jumanca D. , Popa M. , Buzatu A.R. , Horhat R.M. , Cândea A.C. , Dinu Ș.
Published: November 2024

Purpose: The study refers to the linear dimensional stability of silicone elastomers by comparing silicones with condensation curing and silicones with addition curing. Materials and Methods: The present research is represented by an "in vitro" study, interested only in the evolution of the dimensional stability of silicone elastomers in terms of the material used. A control model was created made of a hard plastic with which the existing samples were compared. The photographic documentation of each study model was made, in order to later document the differences obtained compared to the control model. Results: All photos taken were analyzed using a photo analysis software (UTHSCSA ImageTool, version 3.0). The measurement results were recorded in tables and statistically analyzed. Conclusions: The ideal material in terms of dimensional stability is represented by addition cure silicone.
The role of dental plaque disclosing agent in oral hygiene improvement among a group of institutionalized children
Authors: Ilici R.R. , Cărămidă M. , Sfeatcu R. , Oancea R. , Mihai C.R. , Tribus L.
Published: November 2024

Oral hygiene is precarious among institutionalized children, because free treatments are only available subject to certain conditions and because they cannot be supervised while they brush their teeth. Material and methods: the study includes 31 subjects who were clinically examined for the determination of the oral hygiene level, and who filled out a questionnaire regarding their attitude towards the disclosing agents. Results: The average value of the DIS index prior to the application of the disclosing agent was of 1.12, with a 1.34 mean value post-application (satisfactory hygiene). The hygiene level improved with the use of the correct technique and the disclosing agent, with values between 0.1-0.6 (good oral hygiene). Conclusion: There are clear results in terms of change in the children’s behaviour related to dental hygiene, supplemented by the improvement of the oral hygiene level following the removal of the bacterial plaque deposits revealed by the disclosing agents.
Hemisection: A conservative management of an abutment mandibular molar tooth - Case report
Authors: Todor L. , Bonta D.F. , Todor S.A. , Porumb A. , Cosoroaba R.M. , Popovici R.A. , Pricop M.O.
Published: November 2024

Hemisection of the mandibular molars is an option for surgical treatment when a vertical coronal fracture has occurred and a root is healthy. This article illustrates a case in which the damaged terminal abutment was part of a fixed prosthesis. The loss of a distal abutment can result in the patient wearing a removable partial denture. Hemisection and fixed prosthetic rehabilitation gave a satisfactory result. This treatment option should always be considered before tooth extraction and implant therapy.
Therapeutical related quality of life in oncologic patient
Authors: Balean O.I. , Jumanca D. , Sava-Rosianu R. , Dumitrescu R.C.
Published: November 2024

Cancer, a word that is becoming more and more common nowadays, is an abnormal cell proliferation followed by its spread to the rest of the body. The aim of the paper is to assess the quality of life of patients with cancer. We follow both the etiological factors of the diseases, also the side effects of the performed therapy and the correlation of the obtained data from the completion of a questionnaire containing 19 questions. The average age for females is 52 years, compared to 48 years for males. Of the study group 71% had difficulty closing / opening the oral cavity, 32% stated that their pathology was in stage III (32%), the highest percentage of oncological treatment was occupied by chemotherapy and radiotherapy Regarding the risk factors that could cause malignancies, 59% of the study group stated that they were smokers. Pain or discomfort when chewing are present quite often in 36% of respondents and 18% very often. Correlating a patient's health history, observed clinical changes, and the relative risk associated with prompt use of appropriate and proven diagnostic methods will ensure that physicians provide patients with an optimal level of management for a possible long-term satisfactory outcome.
An orthodontic approach in the management of Molar-Incisor Hypomineralisation (MIH)
Authors: Mărginean Khattab M.A. , Motoc G.V. , Vaida L. , Olariu I. , Motoc O. , Milutinovici R.A. , Dinu S. , Popa M.
Published: November 2024

Molar Incisor hypomineralisation is a frequent disorder of the enamel of permanent first molars and incisors during childhood. The management of compromised first molars in children represents a clinical challange to the dental team. Management is a multidisciplinary approach and sometimes orthodontist involvement is needed. Extraction of the first molar is a difficult decision for the dental team and also for the parents during early ages. Clinicians should be aware of orthodontic results of extractions when they decide to perform them during the treatment. An extractive strategy with orthodontic considerations is a valid therapeutic option with a good cost-effectiveness ratio in the management of MIH.
Oral Health Knowledge among Healthcare Personnel in Arad, Romania
Authors: Olariu T. , Bran L.R. , Olariu I. , Lile I.E. , Tanase A.D. , Damian G.
Published: November 2024

Oral health reflects health in general, being an important indicator of knowing the determinants of health. This study examines the knowledge of oral health and oral hygiene habits among 144 respondents. Methods: The study was based on 15 questions, data being processed by IBM SPSS Statistics. Results: only one question received the correct answer unanimously, the percentages of correct answers to the others being variable between 4.9-98.5% (p ≤ 0.001). The better oral health knowledge (p ≤ 0.001) it was related to fluoridation, visits to the dentist, gingivitis prevention and ideal toothbrush, while other subjects were disappointingly poorly known. Conclusion: the results show that oral ealth education must be continuous, especially among health workers, who also have the role of trainers of the general population regarding the determinants of health status.
The benefits of Calendula officinalis extract as therapeutic agent in oral healthcare
Authors: Potra-Cicalău G.I. , Ciavoi G. , Todor L. , Iurcov R.C. , Iova G. , Ganea M. , Scrobotă I.
Published: November 2024

People’s health is favorable impacted by medicinal plants. In addition to their conventional purpose, many isolated chemicals from herbs have beneficial therapeutic characteristics for treating various disorders. In this review, the usage of Calendula officinalis will be discussed in relation to pathologies that affect the oral cavity, such as dental caries, gingivitis or periodontitis. Calendula officinalis extract is able to decrease inflammation through pro-inflammatory cytokines down modulation and promotes antioxidant and immunomodulatory effects—as a result of the presence of polysaccharides and flavonoids in the plant—the main biological actions that make it effective in oral healthcare.
Processing Technologies of Polymers for Provisional Prosthesis
Authors: Modiga C. , Pop D.M. , Miron F.F.D. , Cojocariu A.C. , Marinescu A.G. , Tănase A.D. , Sinescu C. , Romînu M. , Negruţiu M.L. , Craciunescu E.L.
Published: November 2024

Aim and objectives Dental practice is tending to remove the metallic component of fix partial prosthesis due to unfavourable mechanical behaviour. The polymers are used for prosthesis with metal free infrastructures and optimal function. Material and methods Polymers used for provisional prosthesis can be used with different technologies and have different mechanism of initiating the polymerization. Thermoplastic and chemoplastic polymers need different technologies and technological alternatives are: subtractive CAD-CAM, milling, printing technology and polymers injection. Results The chosen materials and manufacturing technologies may influence the success of the final prosthetic treatment. The standard and quality of provisional restoration is decisive for a successful prosthetic treatment. Conclusions Materials used are highly biocompatible and resistant to dental plaque adhesion. Present polymers induce low periodontal inflammation due to the lack of residual monomers.
Exploring the Pharmacotoxicological Mechanisms of Botulinum Toxin on Healthy and Tumoral Oral Cells
Authors: Castiglione L. , Buzatu R. , Dehelean C. A. , Sinescu C. , Murariu M.
Published: November 2024

This study investigates the pharmacotoxicological action mechanisms of botulinum toxin (BT) on oral cellular health, comparing its effects on healthy and tumoral cells in the oral cavity. Utilizing primary cultures of oral keratinocytes and fibroblasts, alongside oral squamous cell carcinoma (SCC) lines, the research assesses BT's cytotoxic, antiproliferative, and migration effects under controlled in vitro conditions, complemented by in ovo chorioallantoic membrane (CAM) assays to evaluate vascular irritant potential. Results indicate a clear dose-dependent cytotoxicity of BT across all cell types. Viability and proliferation rates for healthy keratinocytes and fibroblasts slightly decreased to 95% and 96% at low BT concentrations, with more pronounced effects observed in SCC cells (90% viability). At higher concentrations, viability dropped significantly to 70% for SCC cells, highlighting BT's potential for selective tumoral targeting. Cell migration assays revealed significant reductions in motility for all cell types, suggesting implications for wound healing and tumoral invasion. CAM assay outcomes demonstrated BT's minimal irritant effects at low doses, with increasing vascular irritation observed at higher concentrations. Conclusively, this study underscores the importance of concentration in BT's cellular impact, advocating for optimized therapeutic applications in dental medicine that minimize adverse effects while leveraging its antitumoral potential.
Augmentation of the Mandibular Alveolar Ridge Using Khoury Technique – Case Presentation
Authors: Todor L. , Bonta D. F. , Kozma L. , Nagy B. E. , Todor S. A. , Domocoș D.
Published: November 2024

Implant-prosthetic rehabilitation of edentulous patients with various forms of bone atrophy represents a challenge in oral implantology. The long-term success and stability of dental implants is directly dependent on the quality and quantity of the supporting bone and surrounding soft tissue. When bone volume is inadequate for implant placement, a variety of bone augmentation techniques and materials can be used. Autogenous bone augmentation, autograft, is considered the gold standard in bone grafting, due to its biocompatible, osteoconductive, osteoinductive and osteogenic properties. The technique of obtaining autografts from the mandibular retromolar area is also called the Khoury technique or the split bone block technique.
Dental Erosion in Children and Adolescents from Timiș County – a Statistical Study
Authors: Luca M. M. , Nikolajevic-Stoican N. , Popa M. , Bonaț N. , Darie O. , Țucu M. , Buzatu R.
Published: November 2024

The study that we conducted highlights the role of the level of awareness among legal representatives of minor patients regarding dietary habits, interest in dental hygiene, and the presence of potential conditions that may influence the occurrence of dental erosion. Through a questionnaire, the study will examine both the parents' or caregivers' knowledge level on these aspects and the dietary behaviors of the children and adolescents in question. Dental erosion is the consequence of dental wear through the contact of an acid substance with the dental surface, without bacterial component being involved. The first side effect, which is also pointed out by the patient is flagged by the loss of dental hard substance, which brings with it the unaesthetic appearance of the teeth. Before reaching dental sensitivity or pain, the patient faces the unaesthetic aspect of lesions. This effect is increasingly common as, in recent times, more and more individuals emphasize aesthetic appearance. Regarding pediatric patients, their requirements are not very demanding initially, gaining significance later when they are integrated into a collective environment.
Multiple sclerosis in the context of rare diseases
Authors: Bronț Maria
Published: November 2024

The study focuses on highlighting the causes that determine the appearance of multiple sclerosis (MS) and on describing the general characteristics of the disease such as pathophysiology or symptomatology, but also on identifying its treatment. An important component of the study refers to the needs and services of the person diagnosed with MS, respectively of their companion. Last but not least, a circumscription of the phenomenon in the Romanian space is considered here.
A ampliação da vulnerabilidade do trabalhador intermitente no contexto da pandemia Covid-19
Authors: Zandonai Camila Dozza
Published: November 2024

O presente estudo visa a analisar a exposição da vulnerabilidade do trabalhador intermitente no contexto da emergência sanitária Covid-19. Para tanto, a partir da análise de dados estatísticos, serão examinados alguns aspectos da vivência laboral dos trabalhadores intermitentes que possibilitam verificar seu perfil e sua vulnerabilidade, mais ampla do que a dos demais trabalhadores empregados. Inserido na legislação com o intuito legal de formalizar a situação de trabalhadores que ficavam à margem de proteção jurídica, bem como diminuir os níveis de desemprego, o contrato de trabalho intermitente é aquele no qual a prestação de serviços, com subordinação, não é contínua, ocorrendo com alternância de períodos de prestação de serviços e de inatividade, determinados em horas, dias ou meses, independentemente do tipo de atividade. O presente estudo visa a analisar a exposição da vulnerabilidade do empregado e do empregador, exceto para os aeronautas, regidos por legislação própria. No entanto, a realidade tem revelado que a imprevisibilidade quanto à existência de jornada e de remuneração torna os trabalhadores intermitentes mais vulneráveis que os demais empregados, ainda que inseridos em um regime de vínculo de emprego. O contexto da emergência da Covid-19 descortina essa situação ao revelar a maior perda inicial de postos de trabalho justamente nas áreas ocupadas por tais trabalhadores.
O impacto da Lei nº 14.010/2020 na prescrição trabalhista
Authors: Belutto Renan Martins Lopes
Published: November 2024

Em virtude da pandemia causada pelo novo coronavírus, as autoridades sanitárias determinaram diversas restrições à circulação das pessoas, o que produziu enorme impacto no Brasil e no Mundo. Diante dessa crise de saúde e econômica, o Congresso Nacional editou a Lei nº 14.010/2020, estabelecendo o Regime Jurídico Emergencial e Transitório das relações jurídicas de Direito Privado, com o fim de dar tratamento especial aos contratos firmados entre particulares durante o período de enfrentamento da pandemia. Entre as disposições dessa Lei, foi criada uma nova causa de impedimento e suspensão do prazo prescricional. Neste trabalho, serão examinados os fundamentos da prescrição no Direito do Trabalho e a aplicabilidade da nova regra aos créditos trabalhistas.
Competência da Justiça do Trabalho em um mundo do trabalho em transformação
Authors: Cezario Priscila Freire da Silva
Published: November 2024

A Justiça do Trabalho, inicialmente vocacionada à relação de emprego, viu sua competência reduzida com o movimento de fuga do Direito do Trabalho. A Emenda Constitucional (EC) nº 45 (BRASIL, 2004), ao migrar da relação de emprego para a de trabalho, possibilitou o alívio da fuga. O Supremo Tribunal Federal (STF), porém, tem tratado as relações de trabalho e de emprego como  sinônimas e, assim, colocado em risco a própria existência da Justiça do Trabalho. Nesse contexto, analisa-se como tem sido e como deve ser entendida a expressão “relação de trabalho” para fins de fixação da competência da Justiça do Trabalho na vigência da Constituição de 1988.
ELEMENTOS DA PRIMEIRA ONDA DE RENOVAÇÃO DO ACESSO À JUSTIÇA DE MAURO CAPPELLETTI E BRYANT GARTH NO JULGAMENTO DA ADI 5.766/DF SOBRE A REFORMA TRABALHISTA
Authors: Soares Felipe Lopes , Santos Karinne Emanoela Goettems dos
Published: November 2024

O acesso à justiça nas causas judiciais envolvendo questões trabalhistas sofreu um duro golpe com a edição da Lei nº 13.467 (BRASIL, 2017a), chamada de “Reforma Trabalhista”. Uma de suas inovações foi desnaturar o instituto da justiça gratuita ao permitir a cobrança de honorários de sucumbência e honorários periciais mesmo quando o benefício foi deferido. O Supremo Tribunal Federal (STF)  declarou essa mudança inconstitucional no julgamento da ADI nº 5.766/DF (BRASIL, 2022), resgatando o espírito da obra “Acesso à justiça” de Mauro Cappelletti e Bryant Garth (1988) em julgamento a respeito de três dos 17 objetivos da Agenda 2030 da Organização das Nações Unidas para o Desenvolvimento Sustentável.
DUMPING SOCIAL EM ESCRITÓRIOS DE ADVOCACIA BRASILEIROS:
Authors: Côrte Vitória Mateus
Published: November 2024

O objetivo do presente estudo foi a identificação e a caracterização da situação de dumping social praticado por escritórios deadvocacia brasileiros ao admitirem profissionais por meio dos chamados “contratos de associação”, inserindo a investigação no contexto mais abrangente de crise e precarização das relações de trabalho. Foram observadas algumas características do mercado de trabalho da advocacia brasileira, com o objetivo de realizar uma análise mais abrangente do fenômeno, cotejando-o com a doutrina e a jurisprudência contemporâneas. Utilizou-se de pesquisa bibliográfica, doutrinária e jurisprudencial a respeito do tema, o qual tem grande relevância na medida em que consubstancia grave fraude às relações de trabalho. O método de abordagem utilizado foi o método jurídico tradicional e a técnica de pesquisa adotada foi bibliográfica e jurisprudencial. As conclusões no sentido da existência do dumping social foram identificadas ao longo do texto e resgatadas e organizadas ao final.
ASPECTOS HISTÓRICOS E SOCIAIS DO SURGIMENTO DA JUSTIÇA TRABALHISTA NO BRASIL E O DISTANCIAMENTO DA COMPETÊNCIA INSTITUÍDA PELA EMENDA CONSTITUCIONAL N.º 45/2004
Authors: Rodrigues Veiga Juliana
Published: November 2024

Em decorrência da notoriedade e da repercussão social e midiática que as recentes decisões que envolvem a apreciação da competência (ou não) da Justiça do Trabalho para decidir questões que orbitam as relações de trabalho, o presente estudo busca investigar as raízes históricas e sociais do Direito do Trabalho e da Justiça Trabalhista. O trabalho se concentra em contextualizar essas áreas jurídicas dentro dos principais marcos históricos, avançando para a análise de decisões do Supremo Tribunal Federal (STF) que apontam para uma possível redução da competência da Justiça do Trabalho, conforme estabelecido pela Emenda Constitucional n.º 45/2004. Destaca-se a relevância das decisões do STF sobre a competência da Justiça do Trabalho, enfatizando-se o papel crucial do STF na fixação de diretrizes trabalhistas numa era marcada por avanços tecnológicos e mudanças no cenário laboral, o que repercute diretamente na construção da jurisprudência e na salvaguarda dos direitos trabalhistas no Brasil. A metodologia utilizada consiste em pesquisa documental, englobando livros, teses, dissertações, artigos científicos e decisões judiciais pertinentes à evolução do Direito do Trabalho e da Justiça Trabalhista.
DIREITO DO TRABALHO E QUALIDADE AMBIENTAL:
Authors: Moraes Alves Bruna Lara , Weyermuller André Rafael
Published: November 2024

O trabalho aborda a temática do Direito do Trabalho e da qualidade ambiental por intermédio de uma pesquisa bibliográfica, de natureza exploratória. O objetivo é compreender a abordagem e as inúmeras similitudes entre a proteção ambiental em sentido macro e as repercussões ambientais no meio laboral, de modo a estabelecer uma relação entre o Direito do Trabalho e a qualidade ambiental. Para isto, imprescindível compreender o Direito do Trabalho, o qual se destina às relações trabalhistas, sendo uma das suas principais funções a de assegurar condições dignas de labor, bem como conferir um espaço laboral seguro e saudável. A história operária perpassou por um longo e revolucionário processo histórico, e frente às inúmeras (r)evoluções do mundo laboral pode-se afirmar que o trabalho é um dos meios pelos quais o indivíduo alcança sua dignidade e sua participação social. Diante da exposição realizada, foi possível compreender que as atividades laborais produzem reações de esfera social, econômica e/ou ambiental na sociedade, sendo impossível desvincular as condições e os riscos existentes dentro e fora dos ambientes laborais, o que também se relaciona com o conceito amplo de meio ambiente, o qual inclui os âmbitos natural, artificial, cultural e do trabalho. Conclui-se que trabalho exercido em justas condições em um meio ambiente equilibrado é uma das vias para a configuração da dignidade humana, o que está relacionado à qualidade de vida do indivíduo e à qualidade do seu entorno. Logo, é possível afirmar que o Direito do Trabalho e a qualidade ambiental convergem na busca por melhores condições ambientais em sentido macro e às relacionadas ao meio ambiente laboral, sendo, pois, confluentes em um objetivo maior: melhorar a qualidade de vida.
Emerging areas of geology research in Southeast Asia
Authors:   Universiti Kebangsaan Malaysia, Malaysia, Pereira Joy Jacqueline
Published: November 2024

The lead paper by Khoong et al. (2024) is a seminal effort to analyze advances in geology and delineate emerging areas in Southeast Asia between 2018 and 2022, using a digital approach. It appears that Indonesia and Malaysia are the most significant contributors of geology knowledge as indexed by the Scopus database during this period, and emerging geology research areas relate to the natural gas, environment, and tourism sectors as well as machine learning and sustainable development. The second paper by Sonie et al. (2024) applies mineralogical and geochemical techniques to make a significant contribution to archaeological records on traditional Malay pottery-making. Historical heritage plays a huge role in developing tourism, and the added insight to these artifacts is important for the sector; an example of an emerging area of geology research. The next two papers by Salimun & Mohamad (2024) and Salman et al. (2024) can be clustered under the conventional topic of engineering geology. This is followed by another two papers by Ishak et al. (2014) and Fong et al. (2024) that relate to depositional environments. Kessler et al. (2024) introduce the subject of hydrocarbon biodegradation in the Malay Basin. The final paper from Mina & Abdula (2024) showcases techniques used in Iraq to characterize source rocks and establish their linkages.
Hydrocarbon potential, source correlation, and paleoenvironmental reconstruction of the Jurassic interval in the Zey Gawra Oilfield, Kurdistan Region, Iraq
Authors:   Department of Petroleum Geoscience, Soran University, PO Box 624, Kurdistan Regional Government, Iraq, Mina Chrokhan Taha , Abdula Rzger Abdulkarim ,   Department of Petroleum Geoscience, Soran University, PO Box 624, Kurdistan Regional Government, Iraq
Published: November 2024

A comprehensive geochemical analysis for the Sargelu, Naokelekan, and Najmah formations cutting rock and crude oil samples from Z1, Z3, and Z5 wells of Hawler Block, Kurdistan Region, Iraq have been studied for source rock evaluation. Depending on the total organic carbon (TOC) content from pyrolysis analyses, the Sargelu and Naokelekan formations are regarded as very good source rocks, and fair source rock for the Najmah Formation. The organic matter in the Sargelu Formation is characterized by types II and mixed II and III kerogens. However, the Naokelekan and Najmah formations are characterized by type II kerogen. The Sargelu and Naokelekan formations’ organic matters are at mature stages; hence, in the oil window, whereas Najmah Formation’s organic matter is at immature stage. Pyrolysis study shows that the Sargelu Formation is oil and gas prone, while the Najmah and Naokelekan formations are oil prone. The biomarkers and bulk properties of the selected oils from Gas Chromatography (GC) and Gas Chromatography-Mass Spectroscopy (GC/MS) analysis show that they originated by the same source rocks. The geochemical characteristics indicate a carbonate source in a reducing environment for the studied formations and oils. Based on the oleanane index, tricyclic terpane indices, C28S/C29S ratios, and gammacerane index, the relative age of the oils and cuttings of Sargelu, Naokelekan, and Najmah formations is Middle to Late Jurassic and deposited under moderate saline condition. The biomarkers parameters show evidence that molecules from the cutting rocks of the Sargelu and Naokelekan formations are related to the oils in Z1, Z3, and Z5 wells. However, they are not related to the Najmah Formation.
Entre o Estado e a filantropia: assistência à lepra na cidade de Salvador, Bahia (1921-1936
Authors: Sampaio Mulle
Published: November 2024

O objetivo do livro é compreender a atuação do poder público e da filantropia na assistência aos leprosos internados no Hospital/Leprosário D. Rodrigo José de Menezes, em Salvador Bahia. O recorte de tempo começa em 1921, quando a Bahia aderiu ao acordo com a União para realizar políticas sanitárias nacionais propostas pelo Departamento Nacional de Saúde Pública e termina em 1936, quando foram suspensas as obras no antigo edifício, localizado na Quinta dos Lázaros.
Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells
Authors: Taylor Olivia , DeGroff Nick , El-Hodiri Heithem , Gao Chengyu , Fischer Andy J
Published: November 2024

The purpose of these studies is to investigate how Sphingosine-1-phosphate (S1P) signaling regulates glial phenotype, dedifferentiation of Müller glia (MG), reprogramming into proliferating MG-derived progenitor cells (MGPCs), and neuronal differentiation of the progeny of MGPCs in the chick retina. We found that S1P-related genes are highly expressed by retinal neurons and glia, and levels of expression were dynamically regulated following retinal damage. Drug treatments that activate S1P receptor 1 (S1PR1) or increase levels of S1P suppressed the formation of MGPCs. Conversely, treatments that inhibit S1PR1 or decrease levels of S1P stimulated the formation of MGPCs. Inhibition of S1P receptors or S1P synthesis significantly enhanced the neuronal differentiation of the progeny of MGPCs. We report that S1P-related gene expression in MG is modulated by microglia and inhibition of S1P receptors or S1P synthesis partially rescues the loss of MGPC formation in damaged retinas missing microglia. Finally, we show that TGFβ/Smad3 signaling in the resting retina maintains S1PR1 expression in MG. We conclude that the S1P signaling is dynamically regulated in MG and MGPCs in the chick retina, and activation of S1P signaling depends, in part, on signals produced by reactive microglia.
Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells
Authors: Taylor Olivia , DeGroff Nicholas , El-Hodiri Heithem , Gao Chengyu , Fischer Andy J
Published: November 2024

The purpose of these studies is to investigate how Sphingosine-1-phosphate (S1P) signaling regulates glial phenotype, dedifferentiation of Müller glia (MG), reprogramming into proliferating MG-derived progenitor cells (MGPCs), and neuronal differentiation of the progeny of MGPCs. We found that S1P-related genes are highly expressed by retinal neurons and glia, and levels of expression were dynamically regulated following retinal damage.
S1PR1
is highly expressed by resting MG and is rapidly downregulated following acute retinal damage. Drug treatments that activate S1PR1 or increase levels of S1P suppressed the formation of MGPCs, whereas treatments that inhibit S1PR1 or decreased levels of S1P stimulated the formation of MGPCs. Inhibition of S1PR1 or SPHK1 significantly enhanced the neuronal differentiation of the progeny of MGPCs. Further, ablation of microglia from the retina, wherein the formation of MGPCs in damaged retinas is impaired, has a significant impact upon expression patterns of S1P-related genes in MG. Inhibition of S1PR1 and SPHK1 partially rescued the formation of MGPCs in damaged retinas missing microglia. Finally, we show that TGFβ/Smad3 signaling in the resting retina maintains S1PR1 expression in MG. We conclude that the S1P signaling is dynamically regulated in MG and MGPCs and activation of S1P signaling depends, in part, on signals produced by reactive microglia.