bluuebunny/crossref_metadata_2025 huggingface dataset:
Some Issues of Contract Follow-up by Treasury Bodies
Authors:   Professor of the Department of Law Theory, Civil and Legal Disciplines of the Volgograd Institute of Management, Mironova Svetlana M. , Derebizova Maria V. ,   Head of the Information and Analytical Sector of the Department of Methodological, Organizational and Information and Analytical Support of the Gorfintekhservis State Public Institution
Published: October 2024

Treasury support of contracts is a budgetary and legal instrument for the efficient use of budget funds, and the clear application of all its procedures in practice will lead to strengthening the financial sovereignty of the Russian Federation and effective and timely resolution of all those strategic goals of the development of the Russian state. The Federal Treasury faces an important task of ensuring the public interest of the state when implementing financing from the budget. At the same time, a balance must be found with the private interests of those persons who act as contractors under government contracts, especially in cases where the issue is the conscientious fulfillment of their obligations by these persons. The article examines a number of issues arising in practice during treasury support of contracts and proposes measures for their regulatory consolidation.
On the Legal Nature of the Pension Reserve Guarantee Fund
Authors:   Auditor of the Internal Audit Service of Deposit Insurance Agency Government-Owned Corporation, Parshukova Anastasia P.
Published: October 2024

The article analyzes the legal nature of the fund for guaranteeing pension reserves. The conclusion is substantiated that the mechanisms for the formation and use of the fund are the subject of financial law and affect the sphere of public finance.
Financial Sovereignty of the Russian Federation in the Context of Eurasian Integration
Authors:   Associate Professor of the Department of Civil Law and Procedure of the International Law Institute, PhD (Law), Yagofarova Inna A.
Published: October 2024

The article analyzes the concept of financial sovereignty of the Russian Federation. The author concludes that financial sovereignty should be regarded as the independence and autonomy of the state in making decisions related to the formation, distribution and use of public funds. A classification of financial sovereignty is proposed. The author advocates the view that, entering into economic integration, the state gives up part of its financial sovereignty by transferring a number of powers to the level of integration associations.
Failure to Provide Criminal History Data as a Basis for Denial of Candidate Registration
Authors:   Senior Lecturer, Postgraduate Student of the Department of Administrative, Financial and Corporate Law of the Novosibirsk State University of Economics and Management, Belyaev Artem I.
Published: October 2024

The issue of criminal records in electoral law has long been one of the most discussed in society. However, it is important to remember that each case has its own characteristics and requires careful consideration. A pressing issue is the candidate’s obligation to indicate information about his criminal record in the application for consent to run. The article presents an analysis of judicial practice on refusal to register a candidate in case of non-compliance with the provisions of substantive law, which is enshrined in the current electoral legislation. The author comes to the conclusion that substantive law and the material legal relations regulated by it have a significant impact on the content of procedural law.
Civil Peace as a Constitutional Law Category
Authors:   Associate Professor of the Department of Civil and Financial Law of the Northern (Arctic) Federal University Named after M.V. Lomonosov, Teterin Aleksandr V. , Chertova Nadezhda A. ,   Vice-Rector for Administrative and Legal Affairs of the Northern (Arctic) Federal University Named after M.V. Lomonosov
Published: October 2024

The constitutional concept of «civil peace» is in the focus of this article. The author analyses normative and doctrinal approaches to establish the civil peace. The experience of Latin American countries proved variability, nonlinearity and non-binary of civil peace. The results of the study indicate the need for an objective assessment of the quality of peace and the normative regulation of criteria for such assessment. An important task is to improve legal, methodological and conceptual foundations for ensuring peace.
Substatutory Regulation of Business Activities in the Mechanism of Assurance of the Current Balance of the Economic System
Authors:   Head of the Department of Constitutional and Administrative Law of the Baikal State University, Yakimova Ekaterina M.
Published: October 2024

The state economic policy is built on the basis of the set goals determined in accordance with the constitutional principles of the economic system. Maintaining a course towards achieving an equilibrium of the economic system, the state uses various tools. The system of constitutional principles of the economic system is reflected in the mechanism for ensuring its strategic equilibrium. However, attention should be paid to the functioning of the current equilibrium mechanism, which is an operational control tool. The article analyzes the possibilities of ensuring the equilibrium of the economic system by by-law regulation. It was concluded that in the ordinary mode of management, and especially in the event of extraordinary situations, it is by-law regulation that becomes the basis for maneuvering by the state in maintaining the equilibrium of the economic system.
Conceptual Legal Basis for the Formation of Information Interaction between Federal Executive Bodies and the Civil Society
Authors:   Associate Professor of the Department of Legal Disciplines of the Civil Defence Academy of the Ministry of the Russian Federation for Civil Defence, Mikhaylova Lyubov L.
Published: October 2024

The article considers the conceptual and legal interdepartmental information interaction of federal executive authorities), identifies problems of legal regulation of forms of interdepartmental information interaction, makes a legal analysis of the application of interdepartmental information interaction the normative legal form of regulation of interdepartmental information interaction and the contractual form of interdepartmental information interaction, defines the range of subjects participating in legal relations of interdepartmental information interaction and identifies problems of formation of legal terminology in this area, recommendations on the regulation of public law relations in the field of interdepartmental information interaction have been developed.
Constitutional Rights of Children: Judicial Recognition and Inclusion in Constitutional Texts
Authors:   Associate Professor of the Department of Management of Activities of Public Order Maintenance Subdivisions, Kiryukhin Vladimir V.
Published: October 2024

At present, children's rights are subject to special protection and defence. However, it was not always so. Children's constitutional rights have not kept pace with world constitutionalism. An analysis of the constitutional traditions of different states shows that the consolidation of children's rights has undergone a long period of legal consolidation and the most important place in this process is occupied by the Convention on the Rights of the Child of 1989, which approved the recognition of children's rights and their inclusion in the constitutional texts of all new Constitutions of states.
Enhancement of Energy Sustainability of a Constituent Entity of the Russian Federation for Ensuring Energy Security and Economic Development
Authors:   Deputy Minister of the Ministry of Industry, Energy and Trade of the Chechen Republic, Miserkhanov Lukman Kh. , Ezirbaev Timur B. ,   Director of the Institute of Energy of the Millionshchikov Grozny State Oil Technical University, Turluev Ramzan A-V. ,   ead of the Heating Engineer and Hydraulics Department of the Millionshchikov Grozny State Oil Technical University
Published: October 2024

Energy security and sustainability is one of the main conditions for the economic development of an individual republic and Russia as a whole. This article provides a brief historical sketch and an overview of practical measures and scientific proposals for conceptualising ‘energy security’ on the example of the Chechen Republic. The purpose of this review is to show historical problems that can be projected to the current state and utilised in the future. Implementation of target programs and measures proposed in this article in the form of repair and modernization of gas and electricity supply lines and stations, commissioning of new generating capacities in conjunction with an increase in freight traffic both in the republic and transit, reduction of unemployment through job creation, which will be facilitated by the methods presented in the article, among others, will directly improve the situation with payment for housing and communal services and purchasing power, first of all, of the civilian population, as well as objects of the industrial sector.
On the Need for an Integrated Approach in Determining the Big Data Regime in Russian Law
Authors:   Associate Professor of the Department of Civil Law of the Tomsk State University, PhD (Law), Goncharova Valeria A.
Published: October 2024

In this article, using the example of a case initiated in 2017 at the suit of VKontakte LLC against DABL LLC on the prohibition of extracting and using information contained in the databases of the plaintiff’s social network, and considered by arbitration courts of various levels for five years, the existing in Russian law, paradoxes in the definition of the legal regime of Big Data. It is concluded that the current regulation is clearly not enough for the optimal resolution of disputes similar to the above case: taking into account only the provisions of intellectual property law leads to contradictory situations in which the database manufacturer, as the owner of the exclusive right, has a monopoly on generalized and essentially public information about users of its information resources. As a result of the study, a conclusion is drawn about the need for an integrated approach in determining the regime of personal data in domestic legislation, which implies taking into account equally both information and civil legislation, as well as the provisions of the federal laws “On Personal Data” and “On Protection of Competition”.
Barrack Hooliganism (Art. 335 of the Criminal Code of the Russian Federation). Article 3. Military Hazing in View of High- Impact Cases
Authors:   Head of the Department of Judicial, Prosecution and Investigative Activities of the A.S. Griboyedov Moscow University Professor of the Department of Theory and History, Kolokolov Nikita A.
Published: October 2024

This third article continues the study of the concept of barrack hooliganism, which is understood as the aggregate of obviously illegal demonstrative attempts of some military servicemen doing military service by conscription to establish control over other military servicemen and conscripts by applying mental, physical and sexual violence (shadow law). A review of certain high-impact cases gives the author an opportunity to reflect on the gravity of consequences arising as a result of military hazing that is spontaneously formed in the environment of army conscripts in the conditions of the permissive attitude (or even complicity) of officers.
Details of the A.D. Zaykin’s Biography: Scientific Heritage (Part 2). On the 100th Anniversary
Authors:   Head of the Department of Labor and Financial Law of the P.G. Demidov Yaroslavl State University, Lushnikov Andrey M. , Lushnikova Marina V. ,   Head of the Department of Labor and Financial Law of the P.G. Demidov Yaroslavl State University
Published: October 2024

Part one of this article, presented in the previous issue of the magazine, examined the life path of a prominent domestic scientist. In the second part, his scientific heritage is analyzed. Attention is drawn to the features of his scientific creativity, conducting scientific research at the intersection of labor law and economics. A description of A.D. Zaykin’s contribution to the development of doctrines on the legal organization of remuneration and pension legal relations is given.
Apuntes sobre “Filosofía”
Authors: Fonseca Martínez Miguel
Published: October 2024

En primer lugar Wittgenstein plantea una dificultad inherente a la filosofía y es la dificultad de una transformación. La filosofía exige una renuncia del sentimiento más no de la razón. La dificultad de la comprensión del significado, que es quizá la más fuerte dificultad en filosofía, debe ser vencida a través de un cambio en la voluntad.
Leveraging Islamic Social Finance for Fair and Sustainable Tertiary Education Funding for Orphans in Malaysia: Insights from Sri Lanka
Authors: Mustafa Abdul Muiz , Muneeza Aishath , Nouri Rassem
Published: October 2024

The primary objective of this paper is to draw lessons from Sri Lanka's experience with OrphanCare utilizing Islamic social finance, while also identifying avenues through which Malaysia could establish a sustainable model for achieving a similar purpose. This study uses a qualitative, exploratory approach to investigate the operational framework of OrphanCare in Sri Lanka and its potential lessons for Malaysia. Due to limited secondary sources, an unstructured interview with OrphanCare representatives was conducted to gather in-depth insights. The research unfolds in two phases: first, data collection from both primary (interviews) and secondary (reports, literature) sources to identify gaps and challenges; and second, the analysis of this data using content analysis. The OrphanCare interview from Sri Lanka offers crucial insights for Malaysia's mission in enabling orphan access to higher education. Challenges, like financial constraints and limited support networks, align with Malaysia's inequality reduction goals. Tertiary education benefits, including employability and personal growth, are highlighted. Islamic social finance lessons stress its transformative potential, while collaboration and long-term commitment are its strengths. Recommendations include education funds, support networks, career guidance, awareness campaigns, and sustainable collaborations. A regulatory framework featuring the Orphans Education Fund with a 2% annual contribution from listed companies, managed by National Higher Education Fund Corporation (PTPTN), is proposed. This paper demonstrates originality by uniquely proposing the utilization of Islamic Social Finance to enhance orphan access to tertiary education. It draws insights from Sri Lanka's OrphanCare model and presents innovative strategies for Malaysia to tackle inequalities through collaborative efforts and a robust regulatory framework.
Analysis on the Path of Youth Political Identity Education in Bilibili --Take the Central Account of the Communist Youth League of the Bilibili as an Example
Authors: Suo Qiongyao
Published: October 2024

In the era of deep participation in the Internet,social platforms represented by Bilibili are not only media for information sharing,but also exert the influence of ideas and consciousness.In terms of information acquisition,the Central Account of the Communist Youth League on Bilibili integrates the dissemination of political information into daily life.Through personalized expression,emotional resonance stimulates national imagination,and ultimately achieves a high degree of unity in political cognition,political emotions,and political intentions through relationship identifi cation,emotional resonance,and circle affi liation.
Research on the Construction of Teachers in Vocational
Undergraduate Colleges based on the Integration of Industry and Education
Authors: Wang Zhuyu
Published: October 2024

In the current environment of vocational education reform, the construction of teachers in vocational undergraduate colleges has encountered various challenges, and actively promoting the integration of industry and education has become a key way to enhance the strength
of teachers in undergraduate vocational education. By analyzing the shortcomings in the construction of teacher team in vocational undergraduate colleges, this paper expounds the strategy of teacher team construction under the framework of the integration of industry and education.
Explore the Problems and Solutions in the Management
of Financial Funds in Colleges and Universities
Authors: Zhu Jiaona
Published: October 2024

Financial capital management is an important guarantee to realize the normal operation of colleges and universities, and to improve the level of financial management is a key topic of research in colleges and universities. Therefore, some universities continue to
improve and update management measures, hoping to improve the efficiency of the use of financial funds, reasonable allocation of capital
resources. However, in the actual management stage of financial funds, there are still shortcomings, including the low utilization rate of
funds, this paper carries out an analysis of this, describes the problems existing in the management of financial funds in colleges and universities, focuses on the analysis of solutions, in order to provide some suggestions for improving the quality of financial management in
colleges and universities.
Analysis of Water Conservancy Engineering Construction Technology and Quality Control
Authors: Lei Wenbin
Published: October 2024

At the present stage, the development of social economy and science and technology has promoted the prosperity of Chinese water conservancy construction undertakings, some of which water conservancy engineering construction projects have obtained a high level of in- ternational attention and attention. To continue to promote the rapid development of water conservancy construction in our country, it is neces- sary to optimize and perfect construction technology, and strengthen the implementation of quality control measures, to improve the integrity of water conservancy project construction quality. Therefore, this paper briefly analyzes the construction technology and construction quality control of water conservancy projects for reference.
Research on Construction Safety Management
Measures for Building Site
Authors: Miao Zhuang
Published: October 2024

With the rapid development of Chinese construction industry, the scale of construction engineering is more and more large, and the
degree of specialization is constantly improving. In order to gain competitive advantage in the market, construction enterprises must pay
attention to construction safety management and optimization of construction technology. In addition, in order to promote the long-term
and stable development of the project, the project contractor must also pay attention to the quality, efficiency and safety of the construction
environment to ensure the safety of workers' lives and property. Therefore, construction safety management has become an important part
of construction. It is an important strategy to conduct a comprehensive analysis of construction safety hazards, strengthen the construction
of safety management system, improve workers' safety awareness and skill level, and adopt scientific construction technology and
equipment.
Self-empowerment of Small and Medium-sized Enterprises
Authors: Wei Xin
Published: October 2024

In the process of development, small and medium-sized enterprises will face a lot of pressure brought by changes in the market
environment and industry policy adjustments, and some even have to make major adjustments and transformations. How to stabilize the situation in the face of pressure and change and ensure the normal operation of the company is an objective and realistic problem that small and
medium-sized enterprises will encounter.
??Through the in-depth analysis of the business situation of enterprises, it can help enterprises find problems, optimize processes, and formulate targeted strategies and measures. The analysis of business data is the most important and direct way to find out their own advantages
and disadvantages. Through the analysis of these data, enterprises can understand their own financial status, market sales and resource utilization, etc., on this basis, enterprises can find out the existing problems and bottlenecks.
??Through innovation, talent cultivation, cooperation, market development and technology application, smes can enhance their capabilities
and competitiveness, adapt to market changes and achieve long-term success. Therefore, small and medium-sized enterprises should actively
take actions to continuously pursue opportunities and methods of self-empowerment, and achieve continuous self-empowerment by establishing mechanisms and teams for business analysis.
Immunomodulatory Effects of Umbilical Cord Mesenchymal Stem Cells in Acute Graft-Versus-Host Disease
Authors: Zhang Chen
Published: October 2024

Allogeneic hematopoietic cell transplantation (allo-HSCT) is an important method for the treatment of malignant hematological diseases and some non-hematological diseases. Acute graft-versus-host disease (GVHD), as a major complication after allo-HCT, seriously affects the efficacy of transplantation and is the main cause of transplant failure and non-relapse death. Mesenchymal stem cells have
shown great application prospects in the prevention and treatment of aGvHD due to their unique tissue repair and immunomodulatory functions. However, the discovery of MSCs in clinical trials has greatly exceeded the basic research on their physiological properties and functions.
Moreover, the lack of understanding of the immunomodulatory mechanism of MSCs and the lack of specific markers to monitor the therapeutic
response of MSCs in clinical indications have limited the clinical application and transformation of MSCS. In this review, the pathophysiological
process of aGvHD, the functional characteristics of MSCs and the mechanism of their immunosuppressive effect in aGvHD, and the biomarkers
to monitor the responsiveness of MSCs were summarized, and the limitations and feasibility of MSCs in clinical application were discussed.
Critical Reflection on a Specific Teaching ContextExplicit Instruction of Non-Verbal Communication
Authors: Guan Honglei
Published: October 2024

Non-verbal communication has played a vital role in English learning and teaching. The essay includes both-sides debates, complicated
issues in different cultures and countries and constructive recommendations related to the specific learning and teaching contexts. Although
non-verbal communication has some problems to apply, there are still more constructive recommendations to benefit language learning
greatly in the future.
Grey CorrelationAnalysis between Higher Vocational Ed-ucation and Economic Development in Hubei Province
Authors: Zhang Zhexi
Published: October 2024

The relationship between vocational education and coordinated economic development has always been an important topic in the academic circle. This paper analyzes the current situation of higher vocational education and industrial structure in Hubei Province, and uses the gray correlation method to empirically analyze the correlation between higher vocational education and regional economic development and industrial structure in Hubei Province based on the data of Hubei Province from 2018 to 2021. The results show that higher vocational education in Hubei Province has a strong correlation with economic development and is coordinated with industrial structure optimization.
On the Cultivation of Moral Education of High School Students Through Opera Art Education
Authors: Liu Zixiang
Published: October 2024

Based on the theoretical discussion of moral education in music philosophy, this article explores the role of opera art education
in cultivating the moral education of high school students. First, it discusses the psychological characteristics and moral education content
of high school students have important practical significance; secondly, it summarizes the form and characteristics of opera art, as well as
the teaching design in specific practice; then, it analyzes how to form a moral education concept in the opera art teaching process. Finally,
based on the teaching situation in my country, this article puts forward the key points that should be paid attention to in the process of opera art education.
Analysis on Teaching Problems and Countermeasures of
Ideological and Political Theory Courses in Higher Vocational
Colleges from the Perspective of "Question Chain"
Authors: Guo Yujiao
Published: October 2024

Higher vocational colleges aim at cultivating practical and technical talents. As the ideological and political courses based on theory,
they face the problem of preparing for marginalization, and the teaching effect is difficult to guarantee. The question chain teaching mode is
to design the teaching content into a series of questions to inspire students to think and learn, which can effectively make up for the problems
existing in traditional course teaching. Based on this, this paper analyzes the teaching problems of ideological and political theory courses in
higher vocational colleges, and puts forward the teaching countermeasures of ideological and political theory courses in higher vocational
colleges from the perspective of question chain for reference.
Modele biznesu przedsiębiorstw
Authors: Michalak Jan
Published: October 2024

W warunkach nieciągłości zmian w otoczeniu, rosnącej presji konkurencji i konieczności poszukiwania efektywnych rozwiązań kreujących wartość dodaną dla interesariuszy koncepcja modelu biznesu staje się coraz bardziej atrakcyjnym podejściem do zintegrowanego zarządzania strategicznego i operacyjnego przedsiębiorstwem. Niniejsza publikacja – jako jedna z pierwszych w polskim piśmiennictwie – jest poświęcona kompleksowej analizie modeli biznesu przedsiębiorstw, a także odzwierciedleniu mechanizmów ich funkcjonowania w sprawozdaniach finansowych i raportach biznesowych. Zostały tu przedstawione zarówno popularne, jak i mniej znane metody analizy modeli biznesu: szablon modelu biznesowego (business model canvas) A. Osterwaldera i V. Pigneura, trójkąt modelu biznesu O. Gassmana, analiza struktury strategicznego systemu audytu i mapy wartości. Zaproponowano oraz zilustrowano na przykładach sposoby oceny trwałości modelu biznesu z trzech perspektyw: ekonomicznej, społecznej i ekologicznej, a także scharakteryzowano czynniki utrudniające zmianę konstrukcji modeli biznesu.
Ponadto, w książce można znaleźć analizy wpływu modeli biznesu na kształtowanie obrazu jednostki w rachunkowości zarządczej i finansowej oraz zakresu informacji generowanych w różnego typu raportach, również zintegrowanych. W celu wzbogacenia rozważań koncepcyjnych zamieszczono wyniki badań empirycznych dotyczące treści rocznych raportów spółek notowanych na London Stock Exchange, zintegrowanych raportów wybranych spółek z Holandii, Niemiec, Hiszpanii i Polski, a także dziesięć studiów przypadków opisujących debiuty i dalsze losy spółek na alternatywnym rynku papierów wartościowych NewConnect prowadzonym przez Giełdę Papierów Wartościowych w Warszawie, ze szczególnym uwzględnieniem sposobu prezentacji modeli biznesu w dokumentach informacyjnych.
Publikacja jest adresowana do pracowników naukowych, menedżerów przedsiębiorstw, analityków biznesu, studentów z wyższych roczników studiów i słuchaczy studiów podyplomowych z zakresu zarządzania.
Optimizing Productivity and Economics of Maize + Legumes Intercropping: A Study on the Impact of Natural and Organic Farming Practices
Authors: . Raveena , Kumar Rameshwar , . Pooja , Devi Naorem Diana , Verma Ravi , Kaur Navneet , . Shilpa , . Rushali
Published: October 2024

Background: Excessive use of chemical fertilizers in a cropping system adversely affects the soil health and crop productivity. To ensure food security, nutritional balance and environmental sustainability, a shift towards eco-friendly organic farming based agricultural systems was imperative. But it also poses challenges for small farmers who owe a small number of animals and they need to purchase bulk organic manures. Zero Budget Natural Farming (ZBNF) emerges as an alternate and advocate for low-input, climate-resilient practices which include beejamrit, jeevamrit, achhadana and whapasa. With the aim of increasing the production of the crops per unit area in the present study, different intervals (14, 21 and 28 days) of jeevamrit under natural farming plots and matka khad (30 days interval) under organic farming plots were tested in different maize based intercropping systems. Methods: A field experiment was conducted during kharif 2020 and 2021 at the Zero Budget Natural Farm (ZBNF), Department of Organic Agriculture and Natural Farming, CSK Himachal Pradesh Krishi Vishvavidyalaya, Palampur. The experiment was comprised of thirteen treatments which were tested in randomized block design with three replications. Result: Among different treatments significantly higher values of yield attributes and yield of maize were recorded under maize + lobia and jeevamrit spray at 14 days interval during kharif 2020 and maize + soybean and jeevamrit spray at 14 days interval during kharif 2021. In case of economics, higher gross returns, net returns and benefit cost ratio were recorded under maize + soybean and jeevamrit spray at 14 days interval during kharif 2020, whereas during kharif 2021, maize + soybean and matka khad spray at 30 days interval resulted in the highest returns.
Evîn û Leheng: Wuslat û Fîraqa Lehengî di Şahnameyên Kurdî de
Authors: Vali Shahab
Published: October 2024

Bê şik yek ji hestên însanî yên herî giring hesta “hezkirin” û “evîndarbûn”ê ye. Ev hesta evînê bi du têgehên bingehîn watedar dibe: Wuslat û Fîraq. Kesê evîndar dema ku evîndar dibe, bi hemî hebûna xwe li ser armencekê radiweste: gehiştina maşûqa/ê xwe û ji wê/wî dûrnemayîn. Dikare bê gotin ku beşeke giring a tarîxa edebiyata cîhanê li ser têkoşîn û serpêhatiyên aşiq-maşûqên navdar, li ser van her du têgehan (wuslat û fîraq) ava bûye û serpêhatiyên evînê bûne mijara cureyên edebî yên cuda. Têgeha evînê, yek ji mijarên bingehîn ên edebiyata kurdî ye jî û di vê edebiyatê de xwedî tarîxeke pir kevn e. Di edebiyata navborî de pîvanên cuda yên evînê (pîroz/nepîroz) bi berfirehî têne behs kirin. Di edebiyata kurdî de yek ji berhemên edebî yên ku rîwayetên evîn û evîndariyê lê hatine vegotin, Şahnameyên Kurdî ne. Di van berheman de evîn wekî mijareke sereke ya gelek serpêhatiyan hatiye bikaranîn ku wekî destanên lehengiyê tên qebûlkirin. Armanca vê gotarê nîşandan, analîz û nirxandina helwest û reftarên lehengê mîtolojîk/destanî yên kurdî te li hemberî têgehên “wuslat” û “fîraq”ê.
Effect of Covishieldtm (AZD1222) Vaccination on Incidences and Severity of Covid-19 among Health-Care Workers
Authors: Verma Alka , Goel Amit , Yadav Priyank , Bhalchandra Awale Rupali , Khetan Dheeraj , Sanjeev Om P , Gungigaon Mallikarjun
Published: October 2024

Introduction: Limited information is available regarding effect of vaccination on protection against Covid-19 infections and their severity as well. Objectives: In the present study, we assessed the effect of Covid-19 vaccination on incidences and severity of break through Covid-19 infections. Method: This retrospective study was conducted at a tertiary care center in Northern India during one calendar year, 1st August 2021 to 31st July 2022. The study population included Health-care workers (HCWs) who were treated for Covid 19 infection and had already received at least 1 dose of Covishield TM (AZD1222) Covid-19 vaccine. Results: Out of 1868 health care workers enrolled for the study, 513 contracted Covid-19 infections. Amongst infected HCWs, number of single and double doses of CovishieldTM (AZD1222) recipients were 112 and 401 respectively. Out of the 513 covid positive HCWs, 459 (89.4%) had mild disease, whereas 54 (10.6%) had moderate disease. None of the HCWs developed severe disease and no mortality was noted in either group. Conclusion: In this study, we found that immunization with two doses of CovishieldTM (AZD1222) vaccine was associated with decline in number of cases with moderate or severe Covid-19. Moreover, immunization with even single dose of CovishieldTM (AZD1222) vaccine prevented development of severe disease. Henceforth, it is concluded that although, immunization with CovishieldTM (AZD1222) could not protect all recipients from SARS-Cov-2 infection, it did prevent the progress of disease to severe grades.
Topical application of beta-blockers accelerates epithelialization to mesh skin grafted full-thickness burn in sheep
Authors: Nakamoto Kan , Batsaikhan Tsend Ayush , Liu Naiyou , Fagg W. Samuel , Kakizaki Ryuichiro , Heathman Thomas , Enkhbaatar Perenlei
Published: October 2024

Aim : Beta-adrenergic receptor blockers are conventionally used for the treatment of hypertension, tachycardia, and glaucoma. Research has shown that beta-blockers can accelerate wound epithelialization. In this study, we tested the efficacy of the beta-blocker timolol in an ovine model of grafted full-thickness burn wound healing, which closely mimics clinical scenarios.

Methods : Six full-thickness burn wounds were created on the sheep’s posterior surface. Twenty-four hours later, eschars were excised and meshed skin was grafted (Day0). The wounds in the treatment group received topical application of timolol. Blood flow was measured using a blood perfusion imager. Cardiovascular hemodynamics and blood glucose levels were recorded daily. The epithelialization rate on Day 14 was determined by planimetric assay and analyzed by paired t -test. The days that the epithelialization rate exceeded 85%, 90%, and 95% were analyzed by survival analysis. To assess the potential influence of TGFβ, epithelial-mesenchymal transition (EMT), or myofibroblast activation (MFA) on wound healing, the RNA abundance of gene products related to these pathways was measured by reverse transcription and quantitative polymerase chain reaction (RT-qPCR).

Results : The epithelialization rate on Day 14 was significantly higher in the treatment group. The days that the epithelialization rate exceeded 85%, 90%, and 95% were significantly shorter in the treatment group. There was no significant difference in wound blood flow or RNA abundance related to TGFβ, EMT, or MFA-related pathways among the groups at any time point.

Conclusion : The results demonstrate that the beta-blocker timolol accelerates epithelialization of mesh skin grafted full-thickness burn wounds through a mechanism other than improving wound blood flow.
Obesity, kidney and metabolic bariatric surgery: a surgeon’s narrative review
Authors: Chung Yoona , Paik Bomina , Jeon Dongjae , Kim Yong Jin
Published: October 2024

Excess body weight impacts kidney function in individuals with severe obesity, primarily through metabolic alterations in adipocytes, especially in visceral adipose tissue. The relationship between persistent sterile inflammation associated with obesity and the progression of obesity-related kidney disease to chronic kidney disease (CKD) is an area of growing interest. The beneficial effects of weight loss on the prevention of kidney disease and the improvement of kidney function in individuals with obesity have been well documented. Currently, the most effective weight loss strategy is metabolic bariatric surgery (MBS), which has been proven to not only prevent the progression of CKD but also reverse it. However, awareness and understanding of the impact of obesity on the kidney should also extend to the severely obese population with clinically normal renal function. The purpose of this review is to outline the current knowledge on the pathophysiology of obesity-induced kidney damage, the effects of MBS on renal function in severely obese individuals with or without CKD, and provide the current evidence on perioperative management strategies for CKD patients, including diet and nutrition.
OPTIMALISASI PEMASARAN: STRATEGI DAYA TARIK MELALUI VISIBILITAS KEGIATAN MAHASISWA BAGI CALON MAHASISWA BARU DI FIAI UII
Authors: Asharsyira Almeyda , Fitriani Eka , Mizan habibi Moh
Published: October 2024

Penelitian ini mengekplorasi peran kegiatan mahasiswa dalam menarik minat calon mahasiswa baru di perguruan tinggi, yang fokus di Fakultas Ilmu Agama Islam Universitas Islam Indonesia. Studi ini bertujuan untuk memahami persepsi dan harapan calon mahasiswa terhadap kegiatan mahasiswa serta dampaknya terhadap pilihan perguruan tinggi. Metode penelitian yang digunakan adalah kajian kualitatif deskriptif dengan pengumpulan data primer melalui kuesioner dan formulir daring. Hasil menunjukkan bahwa kegiatan mahasiswa dianggap penting dalam meningkatkan kualitas mahasiswa, sementara minat calon mahasiswa baru memungkinkan dipengaruhi oleh variasi kegiatan dan keterlibatannya dalam organisasi mahasiswa. Terobosan penting dalam penelitian adalah peningkatan promosi dan kualitas kegiatan mahasiswa di FIAI , untuk menarik minat calon mahasiswa baru. Penelitian ini memberikan wawasan tentang strategi pemasaran yang lebih efektif bagi institusi pendidikan dan kebutuhan akan adaptasi terhadap perubahan tren pendidikan.
Antifungal Efficacy and Biofilm Inhibition of Candida albicans by Tea Tree Oil (Melaleuca alternifolia) in Vietnam: A Comprehensive Study
Authors: Tuan Dang Anh , Uyen Pham Vu Nhat , Van Nguyen Thi Tuong , Khuon Nguyen Van , Binh Ly An , Nhan Ngo Vo Thien , Masak Jan
Published: October 2024

Candida albicans, a significant human pathogen due to its biofilm-forming ability, poses a serious health risk. This study investigates the antifungal activity and biofilm inhibition potential of Tea Tree Oil (TTO) from Melaleuca alternifolia cultivated in Vietnam. Renowned for its bioactive compounds, including terpinen-4-ol, 1,8-cineole, and terpinolene, the essential oil of M. alternifolia, commonly referred to as TTO, is scrutinized for its impact on C. albicans. The study meticulously determines the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of TTO against C. albicans in both planktonic and biofilm states. Additionally, it assesses the biofilm-forming capacity of C. albicans and establishes the Minimum Biofilm Inhibitory Concentration (MBIC) and Minimum Biofilm Eradication Concentration (MBEC) of TTO. Employing a liquid culture dilution method within a defined concentration range of 0.1 μL/mL to 10 μL/mL, the experimental approach adheres to established protocols. The outcomes reveal a noteworthy MIC and MIC80 of 0.1 μL/mL and 2 μL/mL, respectively, and an MFC of 10 μL/mL for TTO against C. albicans. Furthermore, TTO exhibits an MBIC of 2 μL/mL, showcasing its efficacy in inhibiting biofilm formation. However, the MBEC of TTO remains uncertain, possibly due to insufficient concentration tested, which may not effectively disrupt over 50% of the pre-formed biofilm mass within 24 hours. These findings highlight TTO’s significant potential as both an antifungal agent and a biofilm inhibitor against C. albicans, providing essential insights that could guide the development of new therapeutic approaches for treating fungal infections.
Successful Therapy over 12 Months of People with Cystic Fibrosis with Rare Non-phe508del-CFTR Mutations with Elexacaftor/Tezacaftor/Ivacaftor (ETI)
Authors: Sütering Tomke , Bode Sebastian , Fischer Rainald , Fabricius Dorit
Published: October 2024

Background: Elexacaftor/Tezacaftor/Ivacaftor (ETI) is a CFTR modulator therapy approved for people with cystic fibrosis (pwCF) who have at least one phe508del mutation. However, its approval in the EU for pwCF with non-phe508del mutations is lacking, with limited data on treatment response in this subgroup. Methods: This retrospective study analyzed data from six pwCF (ages 6 to 66) with responsive CFTR mutations (M1101K, R347P, 2789+5G>A, G551D) undergoing off-label ETI therapy. Evaluations were conducted at 0, 3, 6, 9, and 12 months, assessing lung function (FEV1), sweat chloride levels, BMI, quality of life (CFQ-R), medication satisfaction (TSQM), ENT symptoms (SNOT-22), and physical performance. A control group of four pwCF with classic symptoms and no ETI treatment was included. Results: FEV1 improved significantly after 3 and 6 months (p<0.05) and stabilized by 12 months. Sweat chloride levels decreased significantly, with four pwCF achieving levels below 60 mmol/l. Improvements in ENT and respiratory symptoms, medication satisfaction, and increased BMI were noted. Conclusion: ETI demonstrates high efficacy in selected non-phe508del mutations, offering an effective treatment option that warrants further monitoring and evaluation.
Malaria Prevention for Pregnant Women and Under-Five Children in 10 Sub-Saharan Africa Countries: Socioeconomic and Temporal Inequality Analysis
Authors: Okova Denis , Lukwa Akim Tafadzwa , Oyando Robinson , Bodzo Paidamoyo , Chiwire Plaxcedes , Alaba Olufunke A
Published: October 2024

Malaria remains a public health challenge in low- and middle-income countries (LMICs). Despite gains from strategies like Insecticide Treated Nets (ITNs) and Intermittent Preventive Treatment during pregnancy (IPTp), significant socioeconomic inequalities persist, particularly among pregnant women and children under five. This study analysed temporal and socioeconomic inequalities in malaria prevention in sub-Saharan Africa (SSA). Methods: Nationally representative Demographic Health Surveys from 10 SSA countries were used, comparing two time periods. Changes in ITN use by pregnant women and children under five, as well as IPTp coverage, were assessed. Inequalities based on socioeconomic status (SES) and residence were analysed using the Erreygers Normalized Concentration Index and Theil index.. Results: Results revealed significant variability in ITN use and IPTp coverage between and within countries. Eight countries showed improvements in ITN use during pregnancy, with Nigeria seeing a 173.9% increase over five years. Burkina Faso and Tanzania consistently reported high ITN use (~87%) in children under five. IPTp coverage increased in all countries except Kenya. Decomposition using the Theil index indicated that within-group inequalities, particularly based on SES and residence, were the primary drivers of disparities. Conclusion: To ensure progress toward universal health coverage, malaria prevention programs must prioritize vulnerable populations and be continuously evaluated.
Use of Light Emitting Diodes on the In Vitro Rooting of Apple Tree Rootstocks
Authors: Scolaro Adriana Maria Tomazini , De Martin Mariuccia Schlichting , Vieira Renato Luis , Schveitzer Bianca , de Souza Edson Luiz , Borges Endler Marcel
Published: October 2024

This study presents a novel investigation into the use of Light Emitting Diodes (LEDs) for the in vitro rooting of 'Marubakaido' and 'M9' apple tree rootstocks, marking the first time this approach has been reported in the literature. The research compares four different light sources: blue LED (450 nm), red LED (660 nm), a combination of red and blue LEDs, and traditional fluorescent lamps as a control. Mini-cuttings were inoculated in Murashige & Skoog (MS) medium with reduced nutrient concentrations and supplemented with indoleacetic acid (IAA) and sucrose. The explants were incubated under controlled conditions for 30 days, allowing for a thorough evaluation of the effects of different light sources on various growth metric. The study found that blue LEDs significantly increased dry mass accumulation in 'Marubakaido' seedlings compared to both red LEDs and fluorescent lamps, demonstrating the effectiveness of LEDs in promoting plant growth. Utilizing LEDs not only enhances seedling development but also offers economic benefits over fluorescent lamps. LEDs are known for their high luminous efficiency, low energy consumption, and long lifespan, which can lead to reduced operational costs in plant production systems. This research not only contributes to the understanding of light effects on plant tissue culture but also suggests that the combination of blue and red LEDs can serve as a viable alternative to fluorescent lamps, potentially transforming practices in the field of horticulture and plant propagation.
Polymeric Infrared and Fluorescent Probes to Assess Macrophage Diversity in Bronchoalveolar Lavage Fluid of Asthma and Other Pulmonary Disease Patients
Authors: Zlotnikov Igor D. , Kudryashova Elena Vadimovna
Published: October 2024

Bronchial asthma remains a serious medical problem, as approximately 10% of patients fail to achieve adequate symptom control with available treatment options. Macrophages play a pivotal role in pathophysiology of asthma, as well as in some other respiratory disorders. Typically, they are classified into two major classes, M1 and M2, however, recent findings indicate that in fact there is a whole range of macrophage polarization and functional diversity beyond this bimodal division. Isolation of individual cell sub-populations and identification of their role and diagnostic/therapeutic significance is still a challenge. Here we have attempted to assess the differences between patient-derived macrophage populations from bronchoalveolar lavage fluid (BALF) samples in different pulmonary disease conditions, based on their capability to interact with a range of specific as well as relatively non-specific carbohydrate-based ligands (containing galactose, mannose, trimannose, etc). Obviously, the main target of these ligands was CD206, however, other minor receptors, able to bind carbohydrates, have also been reported for macrophages. In addition, variations in receptor clustering and distribution may substantially affect affinity to the same ligand. Interestingly, with a panel of 5-6 different carbohydrate-based ligands with FTIR or fluorescent marker we were able not only to distinguish between healthy and disease states, but also between closely related diseases, such as purulent endobronchitis, obstructive bronchitis, pneumonia, and bronchial asthma. In some cases, the activated macrophage affinity to galactose base ligands was higher than that to mannose, indicating that complexes of CD-206 or other receptors may contribute substantially to macrophage functional features. For further investigation specific sub-populations of macrophages, seen as hallmarks to specific diseases, can be isolated and studied separately, probably giving new insights with diagnostic and therapeutic significance for hard-to-treat patients. Some of the markers varied from 0 to 100% in different types of bronchitis and pneumonia, which, we believe, deserves further investigation. Hard-to-treat group of patients with resistant disease can also be identified with this approach as fingerprint method, with a purpose to find a more targeted therapeutic strategy, improving their clinical outcomes.