bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Factors for Hospital Mortality in Acute ST-Segment Elevation Coronary Syndrome Complicated by Cardiogenic Shock
Authors: Arsenicheva O. V.
Published: August 2021

The aim. To study the risk factors for hospital mortality in patients with acute coronary syndrome with ST-segment elevation (STEACS) complicated by cardiogenic shock (CS).

Materials and methods. A total of 104 patients with STEACS complicated by CS were studied. The follow-up group (group I) included 58 (55,8%) patients who died in hospital (mean age 71,8±7,31 years), the comparison group (group II) – 46 patients, who have been treated and discharged (mean age 59,5±6,18 years). All patients underwent general clinical studies, the level of troponins, lipids, glucose, creatinine in plasma was determined, electrocardiography and echocardiography were performed. Coronary angiography and percutaneous coronary intervention (PCI) were urgently performed. The method of binary logistic regression with the determination of the odds ratio and its 95% confidence interval for each reliable variable was used to identify risk factors for hospital mortality.

Results. In group I patients with CS, compared with group II, patients over the age of 70 (32 (55,2%) vs 10 (22,7%), р=0,0004), with concomitant chronic kidney disease (32 (55,2%) vs 9 (19,6%), p=0,0002), postinfarction cardiosclerosis (30 (51,7%) vs 9 (19,6%), р=0,001) and chronic heart failure of III-IV functional class (32 (55,1%) vs 11 (23,9%), p=0,001) were significantly more often observed. Baseline levels of plasma leukocytes, troponin and creatinine were significantly higher in deceased patients with CS. Left ventricular ejection fraction below 40% was observed more often in the follow-up group than in the comparison group (46 (79,3%) vs 27 (58,7%), p=0,022). In group I, compared with group II, there was a higher incidence of three-vessel coronary lesions (36 (75%) vs 12 (26,1%), p=0,0001) and chronic coronary artery occlusion unrelated to STEACS (25 (52,1%) vs 12 (26,1%), р=0,009). The same trend was observed when assessing the average number of stenoses and occlusions of the coronary arteries. PCI was performed in 43 (74,1%) of the deceased and 43 (93,5%) of the surviving STEACS patients with CS (p=0,009). The follow-up group had a higher rate of unsuccessful PCI (30,2%) vs 3 (7%), р=0,001) and performed later than 6 hours after the onset of an angina attack (28 (65,1%) vs 6 (14%), р=0,0001).

Summary. Hospital mortality in patients with STEMI complicated by CS was associated with the presence left ventricular ejection fraction less than 40%, three-vessel coronary lesion and performing PCI later than 6 hours from the beginning of the pain attack.
Study of Heart Rate Variability in Patients with Chronic Heart Failure and Chronic Obstructive Pulmonary Disease
Authors: Statsenko M. E. , Lopushkova Yu. E.
Published: August 2021

Aim. To study heart rate variability (HRV) in patients with chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) in relation to: blood oxygen saturation level, parameters of respiratory function (RPF), Nt – proBNP concentration in blood plasma.

Materials and methods. We examined 128 outpatients of both sexes. The patients’ age ranged from 45 to 70 years. Group 1 – main (60 patients) with CHF of ischemic genesis of NYHA functional class II – III and GOLD COPD of I – III degree of airflow restriction (GOLD 2019 classification) in the stage of stable remission, group 2 – control group (63 patients), with isolated CHF. All patients with CHF, who were included in the study, had myocardial infarction (AMI) from 1 to 5 years ago. There were no statistically significant differences in the severity of CHF between groups 1 and 2.

Results. In patients with CHF and COPD, in contrast to patients with isolated CHF, a significant prevalence of the frequency of occurrence of the hypersympathicotonic type of autonomic regulation was revealed. Significantly lower indicators of heart rate variability were in the group of patients with concomitant COPD in comparison with patients with isolated CHF. Statistically significant correlations were revealed between HRV parameters and RPF, parameters of blood oxygen saturation level, NT-proBNP concentration in blood. Multivariate regression analysis showed a significant dependence of HRV parameters on the parameters of HRV and the concentration of NT-proBNP in the blood in the group of patients with CHF and COPD.
Chest Pain in the Patient with Arteria Lusoria: A Case Report
Authors: Reznik E. V. , Kemez Yu. V.
Published: August 2021

The most common anomaly of the aortic arch and its branches is the aberrant right subclavian artery – arteria lusoria. Usually, it produces dysphagia or dyspnea and chronic coughing.

Our purposeis to underline that it is necessary to exclude the anomalies of the branches of the thoracic aorta, including arteria lusoria, in the patients with cardialgia of unknown origin.

Clinical case.An 18-year-old female patient without a previously diagnosed chronic pathology was admitted to a hospital with chest pain after emotional stress for about an hour. The ECG revealed a sinus rhythm with a heart rate of 50 per minute, the normal direction of the electrical axis of the heart, the incomplete right bundle branch block, the negative T wave in the lead III. After excluding ischemic heart disease, acute coronary syndrome, pulmonary embolism, contrast-enhanced chest computed tomography revealed an aortic arch anomaly – a. lusoria.

Conclusion.A. lusoria may manifest by cardiac pain. In patients with chest pain of unknown origin, it is advisable to include anomalies of the aorta and its branches, including the presence of the lusoria artery, in the range of differential diagnostics.
Way of application of convolutional neural networks for personality recognition and user emotions by keyboard handwriting
Authors: Kulakov Yurii , Tereikovska Liudmyla , Tereikovskyi Ihor
Published: August 2021

An important direction of increasing the security and expanding the functionality of modern information systems is the introduction of face recognition tools and user emotions by their keyboard handwriting. The expediency of improving the indicated recognition means by introducing modern neural network solutions into them is shown. A way has been developed for using a convolutional neural network for recognizing a user's face and emotions from keyboard handwriting, the features of which are the procedure for adapting the structural parameters of a convolutional neural network of the VGG type to the expected conditions of use and a procedure for determining the input field, which provides the representation of the parameters of colored channels. After adapting the structural parameters, the VGG network was implemented using the MATLAB R2018b application package, which made it possible to carry out computer experiments aimed at verifying the proposed method. As a result of the conducted computer experiments, it was determined that the use of the proposed method of applying a convolutional neural network makes it possible to achieve a user face recognition accuracy of about 82% with 50 learning epochs. The need for further research in the direction of the formation of a training sample is shown, which will ensure high-quality training of the neural network model.
Selection of Priorities in the System of Adaptive Ecological Monitoring During Combat
Authors: Morshch Yevhen , Andriiuk Olena , Lysychenko Kostyantyn , Pruskyi Andrii
Published: August 2021

The paper presents approaches to the development of priorities in the system of adaptive environmental monitoring of areas of hostilities and military exercises. The peculiarities of forming an interval scale for indices and indicators of disturbances of ecosystems that are under the influence of military-man-made load are also given.
Healthcare Priority-Setting in Essential Health Packages for Sexual Reproductive Health: Going Beyond the Commonly Prioritised Services
Authors: Simangolwa Warren , Govender Kaymarlin
Published: August 2021

There is a systematic exclusion of gender-based violence, safe abortion, reproductive cancers, infertility services, comprehensive sexuality education, sexuality services, and STI’s other than HIV in essential health packages in LMICs. To accelerate progress on sexual reproductive health (SRH), the Guttmacher–Lancet Commission proposed the adoption of these interventions into an essential health package of SRH services that should be universally available. In this commentary, we use a healthcare priority-setting processes lens to review the importance of these services for universal health coverage. We isolate inherent challenges in social value judgments for terminal, process and content evidence for their healthcare priority-setting. We then advance promising emerging practical examples from low to middle-income countries on evidence-informed decision-making processes. We recommend capacity development through regional support, generating equity and efficiency evidence and strengthening political and publicly acceptable processes to institutionalise and operationalise evidence-informed decision-making.
РАСПРОСТРАНЕНИЕ ВАРИАНТОВ ВИРУСА SARS-COV-2, ВЫЗЫВАЮЩИХ ОЗАБОЧЕННОСТЬ (VOC) И ИНТЕРЕС (VOI) НА ОСНОВЕ КОЛИЧЕСТВА ИХ ГЕНОМОВ, ДЕПОНИРОВАННЫХ В БАЗУ ДАННЫХ GISAID ЗА НЕДЕЛЮ с 07.08. по 13.08.2021 г.
Authors: Чумачкова Елена , Дмитриева Людмила , Краснов Ярослав , Осина Наталия , Сафронов Валентин , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: August 2021

В обзоре представлен анализ геновариантов вируса SARS-CoV-2, вызывающих озабоченность (VOC) и интерес (VOI) на основе их геномов в базе GISAID за неделю с 07.08. по 13.08.2021 г.
Seçim Çevresi Büyüklüğünün Değişmesinin Çok-Partililiğe Etkisi
Authors: YILMAZ İbrahim
Published: August 2021

Bu çalışmanın amacı seçim çevresi büyüklüğü ile çok partililik arasındaki ilişkiyi, Türkiye’de gerçekleşen, 1 Kasım 2015 milletvekili genel seçimleri ve 24 Haziran 2018 milletvekili genel seçimleri sonuçlarını dikkate alarak analiz etmektir. 16 Nisan 2017 tarihinde gerçekleşen Anayasa referandumunun kabulü ile Türkiye’de milletvekilli sayısı 550’den 600’e yükseldi. Bunun sonucu olarak 33 seçim çevresinin milletvekilli sayısında 1 ile 4 arasında artış meydana geldi ve 48 seçim çevresinde milletvekili sayısı değişmedi. Bu istisnai durum milletvekili sayısı artan seçim çevreleri ile milletvekili sayısı değişmeyen seçim çevrelerinin çok partililik açısından mukayese edilmesine imkân sunmaktadır. Sonuçlar, milletvekili sayısı artan seçim çevrelerinin ortalama etkin parti sayısının, milletvekili sayısı değişmeyen seçim çevrelerinin ortalama etkin parti sayısından daha fazla arttığını işaret etmektedir. Bu farklılık özellikle 2015 seçimlerinde milletvekilli sayısı 5 veya 5’in altında olan seçim çevrelerinden kaynaklanmaktadır.
Multiletramentos e formação inicial de professores de Língua Portuguesa: um olhar acerca das pesquisas no Brasil
Authors: Santos Fernanda Maria Almeida dos
Published: August 2021

Na contemporaneidade, a constante utilização das tecnologias digitais tem desencadeado processos de uso da linguagem cada vez mais dinâmicos e plurais, demandando que os docentes estejam preparados para lidar com práticas de letramentos correlacionadas à diversidade semiótica dos textos e à multiplicidade cultural e linguística das sociedades. Sob essa ótica, este trabalho analisa pesquisas que discutem como os multiletramentos têm sido entendidos/promovidos nos cursos iniciais de formação de professores de Língua Portuguesa, em alguns contextos no Brasil. O referencial teórico do trabalho concilia, especialmente, os postulados de Moita Lopes (2006) e Pennycook (2006) com os pressupostos de Cope e Kalantzis (2000), Rojo (2009, 2012) e as Diretrizes da Educação Brasileira. Constata-se, por meio do mapeamento das pesquisas contidas no Banco de Teses e Dissertações da Capes (2015-2019), a necessidade de ampliação dos estudos na área, pois, de maneira geral, os trabalhos acadêmicos ainda são escassos e não desenvolvem propostas didático-metodológicas embasadas na Pedagogia dos Multiletramentos.
New mitochondrial genome resource for resolving the grey langur species complex
Authors: Hiremath Vipin , Khedkar Gulab , Jadhav Chandrakant Chandrakant , Sanil Raveendranathanpillai , Khedkar Chandraprakash , Prakash Bharathi
Published: August 2021

Among Indian primate species, the gray langur, is widely distributed and shows extraordinary morphological plasticity throughout its range of distribution. Various taxonomic assignments have been suggested and developed over the past century in resolving the systematic position of the gray langur. There was a substantial disagreements on number of species. To bring about some clarity, it has been proposed to use six morphotypes along with ecological niche modelling to form the basis of a taxonomic classification scheme for the grey langurs found in peninsular India. Nevertheless, the validation for these ambiguities in species numbers is necessary by employing independent tools and molecular data informatics. However, previous attempts at species authentication using molecular data usually rely on only one or a small number of genes. To develop a more reliable method for the reconstruction of phylogenetic relationships of these taxa, and to create an important genomic resource for future studies, we sequenced whole mitochondrial genome of the gray langur Seminopithicus hypoleucos. Our results substantiate the value of sequencing whole mitochondrial genomes for this purpose, and show that developing similar information for new members belonging to the species complex associated to the Hanuman langur clade is essential. Our study proposed a species boundary using different genomic locus to differentiate a species. This may aid to resolve taxonomy and systematic relationships of entire hanuman langur clade in the Indian subcontinent. Further data resource based validity is necessary in this regards.
Sudden Loss of Ovarian Function Exacerbate Cancer-related Fatigue in Patients with Ovarian Carcinoma
Authors: Cai Honghong , Chen Youguo , Shen Fangrong , Sun Huating , Wang Juan , Zhou Jinhua
Published: August 2021

Objective: We aimed to investigate whether ovarian cancer and cancer-related fatigue are associated with a sudden loss of ovarian dysfunction.Methods: In total, we retrospectively analyzed 211 survivors of ovarian carcinoma from the First Affiliated Hospital of Soochow University between January 2015 and January 2020. Fatigue was measured with the Cancer Fatigue Scale (CFS). Single and multiple linear regression were used to determine statistical differences.Results: Fatigue was reported in 206 of all completed questionnaires. Patients who had a menstrual period prior to treatment had a higher fatigue score. The CRF score was highest during the first two years after treatment and gradually decreased over time. Patients with sleep disorders became fatigued more easily. We identified a negative correlation between hemoglobin and CRF. There were no significant correlations between CRF, the number of chemotherapy cycles, the type of chemotherapy regimen, or the pathological subtype of ovarian cancer.Conclusion: CRF is common in ovarian cancer patients and improve CRF are important for improving the quality of life. The fatigue experienced by patients with ovarian cancer may be related to the deprivation of sex hormones. It may be prudent to add such hormones to the treatment regimen in order to improve CRF.
Degradation of Methyl Violet over Fenton-Like Hydroxyapatite Catalysts, Kinetics and Thermodynamics Studies
Authors: Roumila Yasmina , Meziani Djaafar , Debaghi Saadia , Abdmeziem Kaïssa
Published: August 2021

Hydroxyapatite (HA), a calcium hydroxyphosphate was prepared via precipitation method and used as a catalyst in a Fenton like process for methyl violet (MV) dye degradation. This study is aimed to evaluate the effect of hydrogen peroxide concentration, HA dose, initial pH, temperature and MV concentration on the catalyst performance to find out the optimum conditions leading to maximum efficiency of the Fenton process. The results showed that MV dye with a concentration of 20 mg L-1 can be removed within just 10 minutes at the optimal conditions of 36 mmol L–1 H2O2 and 2.5 g L–1 HA at pH of 6.65 and T = 48 °C). The experimental outcome of this study also demonstrates that HA displayed a good recyclability over three cycles; while the use of scavenger highlighted that the hydroxyl radical HO• was the main active species for MV degradation. The catalytic tests result of MV dye degradation were analyzed by the first-order, second-order and Benhnajady-Modirshahla-Ghanbery (BMG) kinetic models, those showing that the Fenton like reaction follows the first-order and BMG models. The activation energy of the reaction and the values of thermodynamic parameters such as standard enthalpy (ΔH*0), entropy (ΔS*0) and Gibbs free energy (ΔG*0) were also evaluated. Those results revealed that the degradation of MV over the as-synthesized material is an endothermic and non-spontaneous process.
Computational Study of Novel Natural Inhibitors Targeting 3-Phosphoinositi-Dependent Protein Kinase 1(PDK1)
Authors: Zhong Sheng , Guo Zhen , Dou Gaojing , Lv Xiaye , Wang Xinhui , Wu Bo , Wang Hongyu , Jiang Yuting , Liu Xiaoxia , Hou Shuya , Liang Luodan , Chen Zhenghe , Mou Yonggao
Published: August 2021

Objective To screen ideal lead compounds with potential inhibition of 3-phosphoinositi-dependent protein kinase 1 (PDK1) from ZINC15 database, which is beneficial to drug design and improvement.Methods The Discovery Studio 4.5 computer-aided virtual screening technique was used to screen potential inhibitors of PDK1. Libdock was used for virtual screening and scoring of candidate compounds, ADME module was used for physical and chemical properties and toxicity analysis, and CDOCKER module was used for molecular docking analysis. The binding affinity of ligand-PDK1 was studied through molecular docking, and the stability of ligand-PDK1 in the natural environment was analyzed through molecular dynamics simulation.Results Two natural compounds ZINC00000157721 and ZINC000034189841 were screened from ZINC15 database. These two compounds have no CYP2D6 inhibition, easy to pass the blood-brain barrier, no hepatotoxicity, high binding affinity with PDK1, higher stability in the natural environment than positive drug BX-795, and stable existence.Conclusions The results show that ZINC00000157721 and ZINC000034189841 are ideal and safe lead compounds and have a potential inhibitory effect on PDK1. These compounds are safe candidates and may provide the basis and premise for the design and optimization of specific PDK1 inhibitors.
Entanglement of a System of an Indirectly Linked Two-Coupled-Cavity
through an Optical Fiber Cable for Single Excitation Atomic States in
the Presence of an External Field
Authors: Hanoura Sadek Ahmed
Published: August 2021

The dynamics of the quantum entropies of a system of two cavities coupled by an optical fiber cable, each cavity contains a two-level atom interacting with a single electromagnetic field in addition to an external classical field, is investigated. Under canonical transformations, the considered Hamiltonian is diagonalized. Effective Hamiltonians in three different limiting regimes: namely large optical fiber cable coupling bstrength, large detunig, and comparable detuning and optical fiber cable coupling strength, are derived. The ith ¯ -tom are respectively prepared in the superposition coherent and the ground states while the fields are prepared in the vacuum states. An analytical expression for the solution of the Schr¨odinger equation for each dispersive is derived. The degree of entanglement (DEM) is studied by using von Neumann atomic entropies. The influences of both the optical fiber cable coupling strength and the detuning on the evolution of the DEM ”their values are closely chosen to be compatible with the imposed restrictions for the applications of the different regimes” are analyzed. General conclusions reached are illustrated by numerical results.
Functional analysis of Ectodysplasin-A mutations in X-linked non-syndromic hypodontia and possible involvement of X-chromosome inactivation
Authors: Pan Yuhua , Lu Ting , Peng Ling , Zeng Qi , Huang Xiangyu , Wu Buling , Xiong Fu
Published: August 2021

Background: Mutations of the Ectodysplasin-A (EDA) gene are generally associated with syndrome hypohidrotic ectodermal dysplasia or non-syndromic tooth agenesis. The influence of EDA mutations on dentinogenesis and odontoblast differentiation have not been reported. The aim of this study was to identify genetic clues for the causes of familial non-syndromic oligodontia and explore the underlying mechanisms involved, while focusing on the role of human dental pulp stem cells (hDPSCs). Materials and Methods: Candidate gene sequences were obtained by PCR amplification and Sanger sequencing. Functional analysis was conducted, and the pathogenesis associated with EDA mutations in hDPSCs was investigated to explore the impact of the identified mutation on the phenotype. Capillary electrophoresis (CE) was used to detect X chromosome inactivation (XCI) in the blood of female carriers. Results: In this study, we identified an EDA mutation in a Chinese family：the missense mutation c.1013C>T (Thr338Met). Transfection of hDPSCs with a mutant EDA lentivirus decreased the expression of EDA and dentin sialophosphoprotein (DSPP) compared with transfection of control EDA lentivirus. Mechanistically, mutant EDA inhibited the activation of the NF-κB pathway. The CE results showed that symptomatic female carriers had a skewed XCI with a preferential inactivation of the X chromosome that carried the normal allele. Conclusions: In summary, we demonstrated that EDA mutations result in non-syndromic tooth agenesis in heterozygous females and that, mechanistically, EDA regulates odontogenesis through the NF-κB signalling pathway in hDPSCs. Due to the large heterogeneity of tooth agenesis, this study provided a genetic basis for individuals who exhibit similar clinical phenotypes.
Production And Characterization of Transportation Fuels From Domestic Plastic Wastes And Mixed Virgin Plastics By Low- Cost Catalytic Pyrolysis
Authors: Ghodke Praveen Kumar , Moorthy Krishna , Sharma Amit Kumar , Chen Wei-Hsin
Published: August 2021

With increasing population, modernization, and industrialization, plastics usage is growing daily and results in vast plastic waste. Recycling these plastic wastes to hydrocarbon fuels is challenging due to their different chemical structures, long-chain polymeric compositions, and decomposition/thermal behavior. In the present manuscript, the pyrolysis of domestic plastic waste was carried out at 473 - 973 K in a fixed bed tubular reactor and compared with individual virgin plastics, i.e. HDPE (High-density polyethylene), LDPE (Low-density polyethylene), PP (Polypropylene), and their mixture of (virgin mixed plastic). The experiments were also performed using a low-cost catalyst (mineral clay) to maximize hydrocarbon fuels. At identified optimum operating conditions, the domestic plastic waste and mixed virgin plastics yielded 73.1 wt% and 81.6 wt% liquid hydrocarbons along with 16.9 wt% and 25.5 wt.% pyrolysis gas, respectively. The composition of liquid fuels was analyzed using FTIR and GC-MS in detail, revealing a wide variety of hydrocarbons disbursement in the range of C8–C20. In addition, fuel properties of liquid fuels such as viscosity, density, fire and flash point, pour point, and calorific value was analyzed according to ASTM methods and found to be satisfactory. Based on chemical composition and fuel properties, liquid fuels derived from domestic plastic wastes showed 78.05%, and 61.86 % similarity with diesel, and jet fuels respectively. Non-condensable gases, which mainly consist of ethane and propene with minor amounts of hydrogen and methane, have been identified to be ideal for spark-ignition engine (SI) engines. This study offers a unique technique for converting waste plastics into transportation jet fuel using an affordable catalyst.
Prophylactic Protection Against Respiratory Viruses Conferred by a Prototype Live Attenuated Influenza Virus Vaccine
Authors: Rathnasinghe Raveen , Salvatore Mirella , Zheng Hongyong , Jangra Sonia , Kehrer Thomas , Mena Ignacio , Schotsaert Michael , Muster Thomas , Palese Peter , Garcia-Sastre Adolfo
Published: August 2021

The influenza A non-structural protein 1 (NS1) is known for its ability to hinder the synthesis of type I interferon (IFN) during viral infection. Influenza viruses lacking NS1 (ΔNS1) are under clinical development as live attenuated human influenza virus vaccines and induce potent influenza virus-specific humoral and cellular adaptive immune responses. Attenuation of ΔNS1 influenza viruses is due to their high IFN inducing properties, that limit their replication in vivo. This study demonstrates that pre-treatment with a ΔNS1 virus results in an immediate antiviral state which prevents subsequent replication of homologous and heterologous viruses, preventing disease from virus respiratory pathogens, including SARS-CoV-2. Our studies suggest that ΔNS1 influenza viruses could be used for the prophylaxis of influenza, SARS-CoV-2 and other human respiratory viral infections, and that an influenza virus vaccine based on ΔNS1 live attenuated viruses would confer broad protection against influenza virus infection from the moment of administration, first by non-specific innate immune induction, followed by specific adaptive immunity.
COVID-19 Cases among veterinary practitioners: role played by canine patients in Lagos State
Authors: Shorunke Folajimi O. , Okolocha Emmanuel , Grace S. N. , Usman Aisha , Akano Oluseyi
Published: August 2021

Background COVID-19 was first reported in Nigeria on Feb 27, 2020, as at 9th May 2021 there were 165,382 confirmed cases with 2,065 deaths CFR 1.3%, Lagos accounted for 35% of the cases and 21% of deaths nationwide. Veterinarians play an important role in public health, attending to animal patients and owners, with risk of contracting the virus. We provided epidemiological information on covid-19 among veterinary practitioners and canine contacts in Lagos, during the lockdown and analyzed possible associations.Methods Study carried out in Lagos State, multistage sampling technique used. 5 public and 4 private veterinary facility selected randomly, Clinic registers reviewed and canine blood sample collected for COVID-19 IgG/IgM antibody test. Questionnaires administered to veterinary practitioners in selected facilities, and encouraged to take COVID-19 test. We conducted descriptive statistics using charts, tables and maps, bivariate analysis done, all significant associations at this level was subjected to multivariate analysis.Result Of the 154 canine and 112 veterinary practitioners sampled, 2% of canine and 25.9% of veterinary practitioners returned positive COVID-19 results. Associations were found between returning positive COVID-19 result and residing in Ikeja (OR = 4.12; CI 1.52–11.2, P 0.004) urban settlement (OR = 5.72; CI 1.60-20.44, P 0.003) being a veterinary doctor (OR = 3.64; CI 1.40–9.46, P 0.009) having tertiary education (OR = 3.74; CI 1.04–13.49 P 0.05). Being married was protective (OR = 0.38; CI 0.16–0.93, P 0.04). Only residing in Ikeja was significant at multivariate level.Conclusion In conclusion, 3 canine positive COVID-19 cases where recorded in Ikeja and Ikorodu LGAs, veterinary practitioners had COVID-19 prevalence of 25.9%, associated with residing in Ikeja, urban settlement, being single, being a veterinary doctor, and having tertiary education. No significant relationship found between covid-19 positive veterinary practitioners and canine contacts. We recommended the organization of more IPC training for veterinary practitioners.
Investigating The Effect of Surface Finishing On Performance of Designed Aerostatic Bearing For Its Improved Precision Applications
Authors: Jamwal Karan Singh , Singh Anant Kumar , Arora Kunal , Paswan Sunil Kumar
Published: August 2021

Aerostatic bearing is an ultra-precision component that uses a spindle surrounded by a thin film of air. Due to the high accuracy of aerostatic bearing, the demand for these components is very high in electronic, instrumentation, healthcare, and other manufacturing or processing industries. In the present work, the main focused area is on the experimental determination of the effect of roughness parameter on the performance of the aerostatic journal and thrust bearings. To achieve the aim, the aerostatic bearing is designed based on theoretical analysis. The present design is numerically investigated by simulation of airflow in ANSYS Fluent with computational fluid dynamics module. The results from the simulation are validated by the results generated for pressure distribution in previous researches. After performing the finishing on the bearing and spindle surface, the manufactured components are assembled for analysing the variation in radial and axial loads acting on the spindle with the spindle displacement (1-5 μm) in the direction of the load at supply pressures (3-6 bar) in the clearance of 30 μm. For surface improvement of the air bearing, three different techniques are used namely machining, grinding, and magnetorheological finishing. For each roughness reduction technique, the variation in axial and radial loads acting on the spindle is determined with variation in spindle displacement. The experimental results showed the increase in load capacity due to improvement in the surface finish for journal bearing and thrust bearing at 5 µm displacement in the spindle is found to be 0.68 N for machining to grinding and 2.0 N from grinding to magnetorheological finishing respectively. The results determined for the surface finish parameter reveals the effect of surface roughness on the load-carrying capacity of the aerostatic journal and thrust bearing. The current study on the surface finishing of aerostatic bearing is found effective for the applications such as drives in production machines where good grade of surface finish are the major parameters for improving the overall functional efficiency.
Time Changes Everything: Analysing Temporal Patterns of Evaporative Water Loss
Authors: Žagar Anamarija , Carretero Miguel Angel , de Groot Maarten
Published: August 2021

Higher air temperatures and drier conditions may create stronger water vapour pressure and increase rates of cutaneous water loss, while elevated body temperatures may in turn directly speed up metabolic rates that lead to higher respiratory water loss. Therefore, water budgets are an important organismal trait for understanding their responses to climate change. The most common method of water loss estimation combines respiratory and cutaneous pathways by measuring body weight loss over a defined period of time. Currently, obtained values are often summed or averaged for population or species comparisons. We warn about potential statistical problems using average or summed values of water loss due to emerging temporal patterns. In this study we used a model dataset of lizards and to investigate temporal patterns in water loss datasets. We found that temporal patterns strongly vary across datasets and often deviate from the summed/average profile. Also, the duration of the experiment needs to remain long enough to detect the temporal patterns and produce representative results, while averages at different end-points of the experiment will also vary with temporal patterns. We propose that a simple statistical approach including hour of the experiment as non-linear explanatory variable in GAMM is used to investigate and adequately account for temporal patterns, which will ensure comparability of studies using meta-analyses in the future. Found signal of temporal variation in water loss also suggests that it holds significant biological relevance, potentially mostly connected to behavioural but also physiological adjustments and needs research attention in the future.
Spatial Biomass Production And Seasonal Nutrient Limitation Transitions In A Tributary of The Three Gorges Reservoir, China
Authors: Nwankwegu Amechi Sampson , Li Yiping , Zhang Lei , Huang Yanan , Xie Deti , Norgbey Eyram , Paerl Hans W.
Published: August 2021

The freshwater ecosystem characteristics in terms of nutrient inventory across seasons, spatial variations of chl-a biomass, and the phytoplankton community structure are prudent ecological assessment indices for a bloom management protocol. We evaluated the spatial and seasonal chl-a distribution under different nutrient conditions and phytoplankton community structure in a eutrophic Three Gorges reservoir tributary China. Result showed significant variations in biomass production with the mainstream reaches severely affected. The nutrient addition bioassay demonstrated significant stimulations on growth in both autumn and summer. The nutrient limitation pattern shifted from P in autumn and spring to N limitation during summer. Combined additions of trace metals with N, P, and Si in autumn and Fe alone enrichment in summer and spring showed maximum productivity. The phytoplankton community structure demonstrated strong sensitivities to seasonal variabilities with regime shift from Cyanophyta, dominated by the toxic and hypoxia generating, Microcystis spp in both autumn and summer, the Cryptophyta dominated by the Chroomonas acuta in spring to the Bacilliariophyta dominated by the genera, Cyclotella in winter. This reflected the ability of the Bacilliariophyta to thrive under a low-temperature condition. Combined N&P led to significant growth stimulation in summer while P alone controlled the bulk of the growth in autumn. The study points to the need for extending mitigation steps to the mainstream towards achieving lasting bloom management solution in the impacted tributary.
The Efficacy of Olanzapine-Contained Antiemetic Therapy for Breast Cancer Patients: A Systematic Review and Pooled Analysis
Authors: Xiao Bo-Ya , Lin Guo-He , Liu Zhao-Bo , Tang Yun-Xiang , Wang Bi-Cheng
Published: August 2021

Purpose: As an antipsychotic agent that targets multiple neurotransmitter receptors, olanzapine has been added to antiemetic therapies. However, olanzapine is rarely used in the real-world antiemetic strategies for breast cancer patients who suffered chemotherapy-induced nausea and vomiting. Therefore, in this study, we comprehensively reviewed the antiemetic researches related to olanzapine and pooled analyzed the results from clinical studies to confirm the efficacy of olanzapine in preventing nausea and vomiting in breast cancer.Methods: PubMed, Web of Science, EMBASE, and Cochrane Central databases were searched from inception through April 19, 2021. Both prospective and retrospective studies were eligible. The primary outcomes were complete response (defined as no vomiting and no use of rescue medications) and no nausea rate.Results: Five studies were identified in the systematic review, four of which with 466 breast cancer patients were included in the pooled analysis. In the acute period (0-24 hours), the olanzapine group had significantly higher rates of complete response (71.3% vs 48.1%, odds ratio [OR]: 2.66, 95% confidence interval [CI] 1.39-5.11, p = 0.003) and no nausea (70.0% vs 43.0%, OR: 3.55, 95% CI 1.76-7.18, p = 0.04) than the placebo group. While in the delayed period, the olanzapine group was also superior to the placebo group in terms of the complete response (82.5% vs 63.3%, OR: 3.81, 95% CI 1.58-9.15, p = 0.003) and no nausea (66.3% vs 51.9%, OR: 2.08, 95% CI 1.03-4.21, p = 0.04) rates. During the overall period in prospective studies, the proportions of complete response (50.0% vs 34.2%, OR: 1.93, p = 0.04) and no nausea (51.3% vs 25.3%, OR: 3.40, p = 0.0006) in the olanzapine group were higher than those in the placebo group. Conclusion: Highly emetogenic chemotherapy breast patients could benefit from olanzapine-contained antiemetic therapy. Furthermore, since the cost is low, olanzapine is worth further clinical application and promotion.
Adaptive combination of interventions required to reach population immunity due to stochastic community dynamics and limited vaccination
Authors: Goldenbogen Björn , Adler Stephan , Bodeit Oliver , Wodke Judith , Escalera-Fanjul Ximena , Korman Aviv , Krantz Maria , Bonn Lasse , Torres Rafael Moran , Haffner Johanna , Karnetzki Maxim , Maintz Ivo , Mallis Lisa , Prawitz Hannah , Segelitz Patrick , Seeger Martin , Linding Rune , Klipp Edda
Published: August 2021

Reaching population immunity against COVID-19 is proving difficult even in countries with high vaccination levels. We demonstrate that this in part is due to heterogeneity and stochasticity resulting from community-specific human-human interaction and infection networks. We address this challenge by community-specific simulation of adaptive strategies. Analyzing the predicted effect of vaccination into an ongoing COVID-19 outbreak, we find that adaptive combinations of targeted vaccination and non-pharmaceutical interventions (NPIs) are required to reach population immunity. Importantly, the threshold for population immunity is not a unique number but strategy and community dependent. Furthermore, the dynamics of COVID-19 outbreaks is highly community-specific: in some communities vaccinating highly interactive people diminishes the risk for an infection wave, while vaccinating the elderly reduces fatalities when vaccinations are low due to supply or hesitancy. Similarly, while risk groups should be vaccinated first to minimize fatalities, optimality branching is observed with increasing population immunity. Bimodality emerges as the infection network gains complexity over time, which entails that NPIs generally need to be longer and stricter. Thus, we analyze and quantify the requirement for NPIs dependent on the chosen vaccination strategy. Our simulation platform can process and analyze dynamic COVID-19 epidemiological situations in diverse communities world-wide to predict pathways to population immunity even with limited vaccination.
The Concentrations and Health Risk Assessment of Rare Earth Elements in Tea in China
Authors: Bao Hanbing , Song Yan , Zhou Yujing , Sui Haixia , Yong Ling , Mao Weifeng , Wang Yibana , Bao Huihui , Xiao Xiao , Zhang Lei , Yang Dajing , Jiang Dingguo , Li Ning , Wei Sheng , Liu Zhaoping
Published: August 2021

Background

Rare earth element (REE) have been considered to have potential effects on human health. However, little is known about the health risk of REEs exposure among tea drinkers in China.
Objectives

To characterize the concentration of REEs in different categories of tea and assess the health risk of REEs of tea consumers in China.
Methods

4326 tea samples(including oolong tea, dark tea, black tea, white tea, green tea and flowering tea from markets of 24 provinces, autonomous regions and municipalities in China, were analyzed for sixteen kinds of rare earth elements. Combining the REE concentration data with tea consumption data, derived from the China National Food Consumption Survey 2013–2014, the REE exposure level through tea for adults was estimated. Calculate the hazard quotient, and judge the health risk of the population based on the result value
Results

The average concentrations of rare earth elements in Oolong tea and black tea were the highest (1611.8µg/kg and 1435.2µg/kg), and in green tea and flower tea were the lowest (735.1µg/kg and 564.1µg/kg). The content values of light rare earth elements (LREEs) were dominant in 94.53% of tea samples, cerium (431.5µg/kg) was the most abundant, followed by lanthanum (267.3µg/kg). The average daily dose of REEs in tea intake for Chinese adults was 0.0328µg/kg BW. There are statistical differences in REEs exposure among different genders of tea drinkers(p < 0.001). The average daily intake of REEs in tea was highest in men aged 40–60 (mean: 0.0383µg/kg BW, P95: 0.1421µg/kg BW), but did not exceed the acceptable daily intake (51.5µg/kg BW).
Conclusions

Our study suggested the health risk of REEs exposure from tea is low in tea consumers in China.
TP53 Inhibited AR Signaling Promote Enzalutamide Resistance in LNCaP cell
Authors: Long Xiangyu , Jiang Bo , Liu Jiyan
Published: August 2021

Background: To perform gene screening and search key knockout gene associated with enzalutamide resistance in LNCaP cells. Methods: Genome-scale CRISPR-Cas9 transfection were done to screen genes associated with enzalutamide resistance in LNCaP cells. Bioinformatic analysis of TP53 and AR expression correlated with prostate adenocarcinoma by using TCGA database. Knockout interfering RNA (shRNA) were synthesized in lentivirus and transfected into LNCaP cells by using Lipofectamine 3000. TP53 and AR detection was performed by using conventional molecular biology methods, such as western blot, RT-PCR and flow cytometer et al. Results: 27 high (NES<-1.7, P<0.01) and 26 low (NES>1.7, P<0.01) expressed genes were identified in enzalutamide resistance Cells. TP53 interacted with AR may play an important role in the development of enzalutamide resistance from PPI and RNA-seq data. Data from TCGA support that patient with TP53&AR low expression endured higher pathology stage, Gleason grades, more disease progress, recurrence, positive lymphnotes examination numbers and more abnormal bones scan results. LNCaP cell dealt with enzalutamide or with TP53 knockout showed inhibited cell cycle at G0~G1, increased apoptosis percentage and also inhibited cell proliferation. Conclusions: Current data support that TP53 protein inhabiting AR signaling promote enzalutamide resistance in LNCaP cell.
Twelve-Weeks of Virtual and In-Person Exercise Training Improve Static and Dynamic Balance in Female Cancer Patients
Authors: Aliki Katherine L. , Teranishi-Hashimoto Cheri , Yamada Paulette
Published: August 2021

Background: Balance is important for maintaining activities of daily living and functional independence. Whether balance is improved in cancer patients after fitness training is unclear. The purpose of this study was to determine if 12-weeks of exercise improves balance and posture in female cancer patients. Methods: Thirty-eight female cancer patients were enrolled. Of the 16 patients who completed the program (mean age±SD: 65±10 years), 12 participants were novice and 4 were experienced exercisers. Six-weeks of exercise sessions were provided in-person and the remaining sessions were virtually delivered. The American College of Sports Medicine’s exercise recommendations were followed. Novice exercises received 36, 90-minute exercise sessions (3x/week) and experienced exercisers had 24, 90-minute sessions (2x/week). Posture was measured using the plumb line method and overhead squat test; balance was measured using the unipedal single leg stance and limits of stability (LOS). Body composition, cardiorespiratory fitness, muscular strength, and flexibility were also measured. Two-way repeated measures ANOVAs and Bonferroni’s multiple comparison tests were used to determine significant differences. Results: Balance on the left leg (eyes closed) and LOS with leftward excursion were significantly improved in experienced exercisers (P=0.0029), but not in the novice group (P=0.0013). Qualitative data showed that experienced exercisers had improved static and dynamic postural alignment of the lower body. Conclusions: While cardiorespiratory and muscular fitness significantly improved in the novice group, these patients did not show balance and postural improvements. Only the experienced exercisers had significant improvements in static and dynamic balance and lower body posture.
Research on Eco-geological Environment Carrying Capacity for Pingwu County after Wenchuan Earthquake Based on Modified AHP
Authors: wang pu , Liu Yimin
Published: August 2021

Many counties in southwestern China are devastated by the Wenchuan earthquake, and the earthquake also induced lots of geological hazards. So evaluation of the eco-geological environment in the disaster area is essential for county restoration and ecological remediation. This research accounts for Pingwu County, which is 89 km to the epicenter of the Wenchuan earthquake, as a study area to evaluate eco-geological environment carrying capacity. Firstly, three evaluation index layers are built to the eco-geological environment carrying capacity model after the earthquake, including geological environment, ecological environment, and social environment. And then, the evolutionary algorithm(EA) is used to modify Analytic Hierarchy Process(AHP). Through optimizing consistency ratio of AHP, the best consistent evaluation matrix can be obtained. Finally, We calculate the eco-geological environment carrying capacity of Pingwu by the best consistent evaluation matrix, and obtain hierarchical map of the eco-geological environment carrying capacity through grid rasterization. The results show that current eco-geological environment carrying capacity in Pingwu county mainly contains two states, equilibrium and surplus. According to the hierarchical map, this study suggests optimizing the construction of the central area in Pingwu, controlling the scale of regional construction, and maintaining the original ecological species in the natural protection area.
Cancer Risk Behaviors, Cancer Beliefs and Health Information Seeking Among Under-Represented Populations in San Francisco: Differences by Sexual Orientation and Gender Identity
Authors: Santiago-Rodríguez Eduardo J. , Rivadeneira Natalie A. , DeVost Michelle A. , Sarkar Urmimala , Hiatt Robert A.
Published: August 2021

Background

Compared to the general population, sexual and gender minorities (SGM) are at increased risk of some types of cancer, in part due to engagement in high-risk behaviors and lack of adequate preventive care. Understanding how SGM perceive cancer risk and their practices and preferences for accessing health information is key for improving the preventive and healthcare services they receive.
Methods

In this cross-sectional study we analyzed data from the San Francisco Health Information National Trends Survey. SGM were identified by self-report. Differences in cancer risk factors and cancer beliefs as well as health information seeking behaviors and preferences were evaluated by sexual orientation and gender identity (SOGI) using multivariable logistic regression models.
Results

Out of 1027 participants, 130 (13%) reported being SGM. In multivariable models adjusting for age, sex at birth, education and race/ethnicity, current smoking was more common in SGM than non-SGM respondents (OR = 1.62, 95% CI = 1.03, 2.54). No differences in health information seeking behaviors, preferences and cancer beliefs were observed by SGM status. However, SGM reported significantly higher odds of feeling frustrated during the most recent health information search (OR = 1.71, 95% CI = 1.14, 2.56).
Conclusions

In this diverse urban population, SGM were more likely to be current smokers. No differences in preferences for accessing and exchanging health information were reported by SGM status. The drivers of increased feelings of frustration while seeking health information and its implications for SGM health and care merit further evaluation. Also, tobacco cessation interventions should be promoted in this community.