bluuebunny/crossref_metadata_2025 huggingface dataset:
Euglycemic Diabetic Ketoacidosis: A Potential Complication of Treatment With Sodium–Glucose Cotransporter 2 Inhibition
Authors: Peters Anne L. , Buschur Elizabeth O. , Buse John B. , Cohan Pejman , Diner Jamie C. , Hirsch Irl B.
Published: June 2015

OBJECTIVE

Sodium–glucose cotransporter 2 (SGLT-2) inhibitors are the most recently approved antihyperglycemic medications. We sought to describe their association with euglycemic diabetic ketoacidosis (euDKA) in hopes that it will enhance recognition of this potentially life-threatening complication.

RESEARCH DESIGN AND METHODS

Cases identified incidentally are described.

RESULTS

We identified 13 episodes of SGLT-2 inhibitor–associated euDKA or ketosis in nine individuals, seven with type 1 diabetes and two with type 2 diabetes, from various practices across the U.S. The absence of significant hyperglycemia in these patients delayed recognition of the emergent nature of the problem by patients and providers.

CONCLUSIONS

SGLT-2 inhibitors seem to be associated with euglycemic DKA and ketosis, perhaps as a consequence of their noninsulin-dependent glucose clearance, hyperglucagonemia, and volume depletion. Patients with type 1 or type 2 diabetes who experience nausea, vomiting, or malaise or develop a metabolic acidosis in the setting of SGLT-2 inhibitor therapy should be promptly evaluated for the presence of urine and/or serum ketones. SGLT-2 inhibitors should only be used with great caution, extensive counseling, and close monitoring in the setting of type 1 diabetes.
The First Isomorphism Theorem and Other Properties of Rings
Authors: Korniłowicz Artur , Schwarzweller Christoph
Published: June 2015

Different properties of rings and fields are discussed [12], [41] and [17]. We introduce ring homomorphisms, their kernels and images, and prove the First Isomorphism Theorem, namely that for a homomorphism f : R → S we have R/ker(f) ≅ Im(f). Then we define prime and irreducible elements and show that every principal ideal domain is factorial. Finally we show that polynomial rings over fields are Euclidean and hence also factorial
Bidual Spaces and Reflexivity of Real Normed Spaces
Authors: Narita Keiko , Endou Noboru , Shidama Yasunari
Published: June 2015

In this article, we considered bidual spaces and reflexivity of real normed spaces. At first we proved some corollaries applying Hahn-Banach theorem and showed related theorems. In the second section, we proved the norm of dual spaces and defined the natural mapping, from real normed spaces to bidual spaces. We also proved some properties of this mapping. Next, we defined real normed space of R, real number spaces as real normed spaces and proved related theorems. We can regard linear functionals as linear operators by this definition. Accordingly we proved Uniform Boundedness Theorem for linear functionals using the theorem (5) from [21]. Finally, we defined reflexivity of real normed spaces and proved some theorems about isomorphism of linear operators. Using them, we proved some properties about reflexivity. These formalizations are based on [19], [20], [8] and [1].
The Formal Construction of Fuzzy Numbers
Authors: Grabowski Adam
Published: June 2015

In this article, we continue the development of the theory of fuzzy sets [23], started with [14] with the future aim to provide the formalization of fuzzy numbers [8] in terms reflecting the current state of the Mizar Mathematical Library. Note that in order to have more usable approach in [14], we revised that article as well; some of the ideas were described in [12]. As we can actually understand fuzzy sets just as their membership functions (via the equality of membership function and their set-theoretic counterpart), all the calculations are much simpler. To test our newly proposed approach, we give the notions of (normal) triangular and trapezoidal fuzzy sets as the examples of concrete fuzzy objects. Also -cuts, the core of a fuzzy set, and normalized fuzzy sets were defined. Main technical obstacle was to prove continuity of the glued maps, and in fact we did this not through its topological counterpart, but extensively reusing properties of the real line (with loss of generality of the approach, though), because we aim at formalizing fuzzy numbers in our future submissions, as well as merging with rough set approach as introduced in [13] and [11]. Our base for formalization was [9] and [10].
A Case Study of Teacher Personal Practice Assessment Theories and Complexities of Implementing Formative Assessment
Authors: Box Cathy , Skoog Gerald , Dabbs Jennifer M.
Published: June 2015

The value and effectiveness of formative assessment in the classroom has gained an increasing amount of attention during the past decade, especially since the publication of seminal work by Black and Wiliam titled Assessment and Classroom Learning. Since that time, there has been a renewed interest in describing and evaluating teacher practices related to formative assessment. Based on evidence of its effectiveness in the classroom and on improving standardized test scores, many prominent educational entities have initiated reform efforts to promote the use of formative assessment, yet these practices have not been embraced by classroom teachers. This case study investigated internally constructed and externally imposed contextual elements that constrained or facilitated the use of formative assessment by three high school science teachers. Cornett’s curriculum development model of personal practice theories was modified to include assessment, termed personal practice assessment theories (PPATs), and chosen as a framework for the study. This research revealed distinct differences among the three teachers’ PPATs and several different factors that constrained or facilitated the use of formative assessment in their instruction. Most notable of these factors were the forms of teacher knowledge that played a critical role in shaping their assessment practices and had a bearing on their ability to convert espoused theories about assessment into actual classroom practice. Other externally imposed barriers that constrained the use of formative assessment included expectations, habits, and dispositions of students; the pressure that teachers felt to “cover” all of the curriculum in order to prepare students for the end-of-year, high-stakes exam; and an instructivist rather than constructivist approach to teaching and learning. Results from this study add to the growing body of knowledge about the complex terrain teachers negotiate in making teaching and assessment decisions and provides a framework for future studies.
Effects of School Segregation and School Resources in a Changing Policy Context
Authors: Gamoran Adam , An Brian P.
Published: June 2015

Desegregation policies have been rolled back across the country. Some advocates for dismantling desegregation argue that resources allocated to desegregation would pay off better if allocated to improve education in schools with disadvantaged populations. We test this claim by examining student achievement before, during, and after the end of court-ordered desegregation in Nashville, Tennessee. School-by-grade fixed effect models reveal no evidence that increases in a school’s proportion of Black students impeded achievement growth. Increased exposure to students in poverty curtailed achievement growth, but enhanced option schools, which bring extraordinary resources to high-poverty, racially isolated schools, compensated for the effects of concentrated poverty. Schools that became specialized magnet schools, however, did not contribute to achievement gains and in some cases curtailed growth.
Gaseous Products of Incense Coil Combustion Extracted by Passive Solid Phase Microextraction Samplers
Authors: Cheng Wen-Hsi , Lai Chin-Hsing , Tzeng Wen-Jiunn , Her Chyn , Hsu Ya-Han
Published: June 2015

Burning incense indoors is a common behavior in Southeast Asia. In this investigation, needle trap samplers (NTS), a novel, green analytical technology is used for sampling gaseous combustion by-products from sandalwood incense coils. To extract indoor volatile organic compounds (VOCs), two NTS are prepared, one using 60–80 mesh and the other using 100–120 mesh divinylbenzene (DVB) particles packed in 22-gauge stainless steel needles. This work compares extraction efficiency of an NTS and that of a commercially available 100 μm polydimethylsiloxane solid phase microextration (PDMS-SPME) fiber sampler. Experimental results indicated that the 100–120 mesh DVB-NTS performed best among all samplers during a 1 h sampling period. The main extracted compounds were toluene, ethylbenzene, propane, chloromethane, 1,3-butadiene, methanol and dichloromethane. The potential use of small badge-sized or pen-sized NTS for the indoor atmosphere and occupational hygiene applications is addressed.
Silencing of Taxol-Sensitizer Genes in Cancer Cells: Lack of Sensitization Effects
Authors: Huang Shang-Lang , Chao Chuck
Published: June 2015

A previous genome-wide screening analysis identified a panel of genes that sensitize the human non-small-cell lung carcinoma cell line NCI-H1155 to taxol. However, whether the identified genes sensitize other cancer cells to taxol has not been examined. Here, we silenced the taxol-sensitizer genes identified (acrbp, atp6v0d2, fgd4, hs6st2, psma6, and tubgcp2) in nine other cancer cell types (including lung, cervical, ovarian, and hepatocellular carcinoma cell lines) that showed reduced cell viability in the presence of a sub-lethal concentration of taxol. Surprisingly, none of the genes studied increased sensitivity to taxol in the tested panel of cell lines. As observed in H1155 cells, SKOV3 cells displayed induction of five of the six genes studied in response to a cell killing dose of taxol. The other cell types were much less responsive to taxol. Notably, four of the five inducible taxol-sensitizer genes tested (acrbp, atp6v0d2, psma6, and tubgcp2) were upregulated in a taxol-resistant ovarian cancer cell line. These results indicate that the previously identified taxol-sensitizer loci are not conserved genetic targets involved in inhibiting cell proliferation in response to taxol. Our findings also suggest that regulation of taxol-sensitizer genes by taxol may be critical for acquired cell resistance to the drug.
An Exploratory Study of the Factors That May Affect Female Consumers’ Buying Decision of Nail Polishes
Authors: Sun Chen , Adhikari Koushik , Koppel Kadri
Published: June 2015

The objective of this study was to determine what factors female consumers valued more when they buy nail polish. Ninety-eight female consumers participated in a nail polish consumer study at the Sensory Analysis Center, Kansas State University. A questionnaire containing a check-all-that-apply (CATA) question, behavior questions and demographic questions was presented to each consumer. In the CATA question, the factors that may affect consumers’ decision to buy a nail polish were asked, including both sensory and non-sensory factors. The frequency in percent for the factors was calculated. Sensory appeal, price and convenience of usage were the top factors that affected consumers’ buying decisions. Consumers valued sensory appeal and convenience of usage; this suggested that a nail polish company’s product development and advertising departments may want to focus on these two areas, primarily. The information presented in this study could help a nail polish company understand more about consumer segmentation and advertising strategy.
Circulating HMGB1 and RAGE as Clinical Biomarkers in Malignant and Autoimmune Diseases
Authors: Pilzweger Christin , Holdenrieder Stefan
Published: June 2015

High molecular group box 1 (HMGB1) is a highly conserved member of the HMG-box-family; abundantly expressed in almost all human cells and released in apoptosis; necrosis or by activated immune cells. Once in the extracellular space, HMGB1 can act as a danger associated molecular pattern (DAMP), thus stimulating or inhibiting certain functions of the immune system; depending on the “combinatorial cocktail” of the surrounding milieu. HMGB1 exerts its various functions through binding to a multitude of membrane-bound receptors such as TLR-2; -4 and -9; IL-1 and RAGE (receptor for advanced glycation end products); partly complex-bound with intracellular fragments like nucleosomes. Soluble RAGE in the extracellular space, however, acts as a decoy receptor by binding to HMGB1 and inhibiting its effects. This review aims to outline today’s knowledge of structure, intra- and extracellular functions including mechanisms of release and finally the clinical relevance of HMGB1 and RAGE as clinical biomarkers in therapy monitoring, prediction and prognosis of malignant and autoimmune disease.
Contribution to Transfer Entropy Estimation via the k-Nearest-Neighbors Approach
Authors: Zhu Jie , Bellanger Jean-Jacques , Shu Huazhong , Le Bouquin Jeannès Régine
Published: June 2015

This paper deals with the estimation of transfer entropy based on the k-nearest neighbors (k-NN) method. To this end, we first investigate the estimation of Shannon entropy involving a rectangular neighboring region, as suggested in already existing literature, and develop two kinds of entropy estimators. Then, applying the widely-used error cancellation approach to these entropy estimators, we propose two novel transfer entropy estimators, implying no extra computational cost compared to existing similar k-NN algorithms. Experimental simulations allow the comparison of the new estimators with the transfer entropy estimator available in free toolboxes, corresponding to two different extensions to the transfer entropy estimation of the Kraskov–Stögbauer–Grassberger (KSG) mutual information estimator and prove the effectiveness of these new estimators.
Bayesian Approach to Disentangling Technical and Environmental Productivity
Authors: Malikov Emir , Kumbhakar Subal , Tsionas Efthymios
Published: June 2015

This paper models the firm’s production process as a system of simultaneous technologies for desirable and undesirable outputs. Desirable outputs are produced by transforming inputs via the conventional transformation function, whereas (consistent with the material balance condition) undesirable outputs are by-produced via the so-called “residual generation technology”. By separating the production of undesirable outputs from that of desirable outputs, not only do we ensure that undesirable outputs are not modeled as inputs and thus satisfy costly disposability, but we are also able to differentiate between the traditional (desirable-output-oriented) technical productivity and the undesirable-output-oriented environmental, or so-called “green”, productivity. To measure the latter, we derive a Solow-type Divisia environmental productivity index which, unlike conventional productivity indices, allows crediting the ceteris paribus reduction in undesirable outputs. Our index also provides a meaningful way to decompose environmental productivity into environmental technological and efficiency changes.
Analysis of Medium-Scale Solar Thermal Systems and Their Potential in Lithuania
Authors: Valančius Rokas , Jurelionis Andrius , Jonynas Rolandas , Katinas Vladislovas , Perednis Eugenijus
Published: June 2015

Medium-scale solar hot water systems with a total solar panel area varying from 60 to 166 m2 have been installed in Lithuania since 2002. However, the performance of these systems varies depending on the type of energy users, equipment and design of the systems, as well as their maintenance. The aim of this paper was to analyse operational SHW systems from the perspective of energy production and economic benefit as well as to outline the differences of their actual performance compared to the numerical simulation results. Three different medium-scale solar thermal systems in Lithuania were selected for the analysis varying in both equipment used (flat type solar collectors, evacuated tube collectors) and type of energy user (swimming pool building, domestic hot water heating, district heating). The results of the analysis showed that in the analysed cases the gap between measured and modelled data of heat energy produced by SHW systems was approx. 11%. From the economical perspective, the system with flat type solar collectors used for domestic hot water production was proved to be most efficient. However, calculation of Internal Rate of Return showed that a grant of 35% is required for this project to be fully profitable.
Horizontal and Vertical Reinforcement in Global Climate Governance
Authors: Jänicke Martin
Published: June 2015

This paper is dealing with mechanisms that can accelerate the global diffusion of climate-friendly technologies. The accelerated diffusion of low-carbon technology innovation can possibly be achieved by interactive processes such as: (1) mutually reinforcing cycles of policy-induced domestic market growth, innovation, and policy feedback; (2) lead markets and political lesson-drawing, the reinforced international adoption of innovations from pioneer countries; and (3) interaction between the vertical and horizontal dynamics in multi-level systems of governance. The three mechanisms are not exclusive. They can overlap and reinforce each other. After a theoretical introduction they will be described. The empirical focus is on the European system of multi-level climate governance. The paper draws some final conclusions for policy makers.
Illegal Dumping of Toxic Waste and Its Effect on Human Health in Campania, Italy
Authors: Mazza Alfredo , Piscitelli Prisco , Neglia Cosimo , Rosa Giulia , Iannuzzi Leopoldo
Published: June 2015

The region of Campania (particularly Naples and Caserta) has experienced an emergency in the waste management cycle during past years. Although the most critical phase has been overcome after the construction of the incineration plant in Acerra (an old-fashioned technology built up over a few months, whose impact on environment and health has not yet been assessed), most of the underlying problems have not been resolved. The illegal burning of wheels, plastics, textiles, and other industrial residuals, along with the detection of two thousand toxic substance dumping sites, still represents major concerns of environmental pollution and population health. This review summarizes the most relevant studies, which analyzed chemical contamination (primarily dioxins and polychlorinated biphenyls (PCBs)) of the air, soil, water, animals, and humans in Campania. In addition, we reviewed information on population health (i.e., mortality data, congenital malformations, and cancer incidence). Moving from a detailed mapping of (mostly illegal) waste dumping sites in Campania, we have focused on recent studies which have found: (a) high concentrations of dioxins (≥5.0 pg TEQ/g fat) in milk samples from sheep, cows, and river buffaloes; (b) remarkable contamination of dioxin and PCBs in human milk samples from those living in the Naples and Caserta areas (PCDDs+PCDFs and dioxin-like-PCBs (dl-PCBs) assessed at 16.6 pg TEQ/g of fat; range: 7.5–43 pg/g of fat); (c) potential age-adjusted standardized mortality rates associated with some specific cancer types; (d) a statistically significant association between exposure to illegal toxic waste dumping sites and cancer mortality, even after adjustment by socio-economic factors and other environmental indicators.
Mineralization and Detoxification of the Carcinogenic Azo Dye Congo Red and Real Textile Effluent by a Polyurethane Foam Immobilized Microbial Consortium in an Upflow Column Bioreactor
Authors: Lade Harshad , Govindwar Sanjay , Paul Diby
Published: June 2015

A microbial consortium that is able to grow in wheat bran (WB) medium and decolorize the carcinogenic azo dye Congo red (CR) was developed. The microbial consortium was immobilized on polyurethane foam (PUF). Batch studies with the PUF-immobilized microbial consortium showed complete removal of CR dye (100 mg·L−1) within 12 h at pH 7.5 and temperature 30 ± 0.2 °C under microaerophilic conditions. Additionally, 92% American Dye Manufactureing Institute (ADMI) removal for real textile effluent (RTE, 50%) was also observed within 20 h under the same conditions. An upflow column reactor containing PUF-immobilized microbial consortium achieved 99% CR dye (100 mg·L−1) and 92% ADMI removal of RTE (50%) at 35 and 20 mL·h−l flow rates, respectively. Consequent reduction in TOC (83 and 79%), COD (85 and 83%) and BOD (79 and 78%) of CR dye and RTE were also observed, which suggested mineralization. The decolorization process was traced to be enzymatic as treated samples showed significant induction of oxidoreductive enzymes. The proposed biodegradation pathway of the dye revealed the formation of lower molecular weight compounds. Toxicity studies with a plant bioassay and acute tests indicated that the PUF-immobilized microbial consortium favors detoxification of the dye and textile effluents.
Reducing the Oxidation Level of Dextran Aldehyde in a Chitosan/Dextran-Based Surgical Hydrogel Increases Biocompatibility and Decreases Antimicrobial Efficacy
Authors: Chan Maggie , Brooks Heather , Moratti Stephen , Hanton Lyall , Cabral Jaydee
Published: June 2015

A highly oxidized form of a chitosan/dextran-based hydrogel (CD-100) containing 80% oxidized dextran aldehyde (DA-100) was developed as a post-operative aid, and found to significantly prevent adhesion formation in endoscopic sinus surgery (ESS). However, the CD-100 hydrogel showed moderate in vitro cytotoxicity to mammalian cell lines, with the DA-100 found to be the cytotoxic component. In order to extend the use of the hydrogel to abdominal surgeries, reformulation using a lower oxidized DA (DA-25) was pursued. The aim of the present study was to compare the antimicrobial efficacy, in vitro biocompatibility and wound healing capacity of the highly oxidized CD-100 hydrogel with the CD-25 hydrogel. Antimicrobial studies were performed against a range of clinically relevant abdominal microorganisms using the micro-broth dilution method. Biocompatibility testing using human dermal fibroblasts was assessed via a tetrazolium reduction assay (MTT) and a wound healing model. In contrast to the original DA-100 formulation, DA-25 was found to be non-cytotoxic, and showed no overall impairment of cell migration, with wound closure occurring at 72 h. However, the lower oxidation level negatively affected the antimicrobial efficacy of the hydrogel (CD-25). Although the CD-25 hydrogel’s antimicrobial efficacy and anti-fibroblast activity is decreased when compared to the original CD-100 hydrogel formulation, previous in vivo studies show that the CD-25 hydrogel remains an effective, biocompatible barrier agent in the prevention of postoperative adhesions.
Regulation of Human Trophoblast GLUT3 Glucose Transporter by Mammalian Target of Rapamycin Signaling
Authors: Xu Jie , Lu Chunmei , Wang Jiao , Zhang Ruotong , Qian Xin , Zhu Hui
Published: June 2015

Glucose transporter isoform-3 (GLUT3), one of the primary placental facilitative glucose transporters responsible for basal glucose transport, has a crucial role in glucose transport and fetal growth during early pregnancy. A GLUT3 mutation in mice has been reported to cause loss of early pregnancy or late-gestational fetal growth restriction. However, the underlying mechanisms that regulate the placental GLUT3 transporter in humans are largely unknown. In the present study, we used the JEG-3 human choriocarcinoma cell line, which resembles a first trimester placental model, to study the role of the mammalian target of rapamycin complex 1 (mTORC1) in the regulation of placental GLUT3. We combined rapamycin treatment and small interfering (si) RNA-mediated silencing approaches with mRNA and protein expression/localization studies to investigate the alteration of GLUT3 expression and localization following mTORC1 inhibition in JEG-3 trophoblasts. Inhibition of mTORC1 signaling by silencing raptor decreased GLUT3 mRNA expression (−41%) and protein expression (−50%). Similar effects were obtained in cells in which mTORC1 was inhibited by rapamycin. Immunofluorescence analysis revealed that GLUT3 expression was markedly reduced in the cell surface and cytoplasm of JEG-3 cells in response to mTORC1 silencing. Because placental mTORC1 activity and GLUT3 expression are decreased in human intrauterine growth restriction, our data suggested one possible mechanism for the abnormal fetal growth in this pregnancy complication.
Insect Pests and Integrated Pest Management in Museums, Libraries and Historic Buildings
Authors: Querner Pascal
Published: June 2015

Insect pests are responsible for substantial damage to museum objects, historic books and in buildings like palaces or historic houses. Different wood boring beetles (Anobium punctatum, Hylotrupes bajulus, Lyctus sp. or introduced species), the biscuit beetle (Stegobium paniceum), the cigarette beetle (Lasioderma serricorne), different Dermestides (Attagenus sp., Anthrenus sp., Dermestes sp., Trogoderma sp.), moths like the webbing clothes moth (Tineola bisselliella), Silverfish (Lepisma saccharina) and booklice (Psocoptera) can damage materials, objects or building parts. They are the most common pests found in collections in central Europe, but most of them are distributed all over the world. In tropical countries, termites, cockroaches and other insect pests are also found and result in even higher damage of wood and paper or are a commune annoyance in buildings. In this short review, an introduction to Integrated Pest Management (IPM) in museums is given, the most valuable collections, preventive measures, monitoring in museums, staff responsible for the IPM and chemical free treatment methods are described. In the second part of the paper, the most important insect pests occurring in museums, archives, libraries and historic buildings in central Europe are discussed with a description of the materials and object types that are mostly infested and damaged. Some information on their phenology and biology are highlighted as they can be used in the IPM concept against them.
Directional Medium Access Control (MAC) Protocols in Wireless Ad Hoc and Sensor Networks: A Survey
Authors: Wong David , Chen Qian , Chin Francois
Published: June 2015

This survey paper presents the state-of-the-art directional medium access control (MAC) protocols in wireless ad hoc and sensor networks (WAHSNs). The key benefits of directional antennas over omni-directional antennas are longer communication range, less multipath interference, more spatial reuse, more secure communications, higher throughput and reduced latency. However, directional antennas lead to single-/multi-channel directional hidden/exposed terminals, deafness and neighborhood, head-of-line blocking, and MAC-layer capture which need to be overcome. Addressing these problems and benefits for directional antennas to MAC protocols leads to many classes of directional MAC protocols in WAHSNs. These classes of directional MAC protocols presented in this survey paper include single-channel, multi-channel, cooperative and cognitive directional MACs. Single-channel directional MAC protocols can be classified as contention-based or non-contention-based or hybrid-based, while multi-channel directional MAC protocols commonly use a common control channel for control packets/tones and one or more data channels for directional data transmissions. Cooperative directional MAC protocols improve throughput in WAHSNs via directional multi-rate/single-relay/multiple-relay/two frequency channels/polarization, while cognitive directional MAC protocols leverage on conventional directional MAC protocols with new twists to address dynamic spectrum access. All of these directional MAC protocols are the pillars for the design of future directional MAC protocols in WAHSNs.
Dangerous Relations in the Arctic Marine Food Web: Interactions between Toxin Producing Pseudo-nitzschia Diatoms and Calanus Copepodites
Authors: Harðardóttir Sara , Pančić Marina , Tammilehto Anna , Krock Bernd , Møller Eva , Nielsen Torkel , Lundholm Nina
Published: June 2015

Diatoms of the genus Pseudo-nitzschia produce domoic acid (DA), a toxin that is vectored in the marine food web, thus causing serious problems for marine organisms and humans. In spite of this, knowledge of interactions between grazing zooplankton and diatoms is restricted. In this study, we examined the interactions between Calanus copepodites and toxin producing Pseudo-nitzschia. The copepodites were fed with different concentrations of toxic P. seriata and a strain of P. obtusa that previously was tested to be non-toxic. The ingestion rates did not differ among the diets (P. seriata, P. obtusa, a mixture of both species), and they accumulated 6%–16% of ingested DA (up to 420 µg per dry weight copepodite). When P. seriata was exposed to the copepodites, either through physical contact with the grazers or separated by a membrane, the toxicity of P. seriata increased (up to 3300%) suggesting the response to be chemically mediated. The induced response was also triggered when copepodites grazed on another diatom, supporting the hypothesis that the cues originate from the copepodite. Neither pH nor nutrient concentrations explained the induced DA production. Unexpectedly, P. obtusa also produced DA when exposed to grazing copepodites, thus representing the second reported toxic polar diatom.
Synergic Role of Self-Interstitials and Vacancies in Indium Melting
Authors: Montanari Roberto , Varone Alessandra
Published: June 2015

Precursor effects of indium melting have been investigated by means of Mechanical Spectroscopy (MS) and High Temperature X-ray Diffraction (HT-XRD). MS tests evidenced a sharp drop of dynamic modulus in the temperature range between 418 K and 429 K (melting point). At 429 K, HT-XRD showed partial grain re-orientation, peak profile broadening, in particular in the lower part, and peak shift towards lower angles. Experimental results are consistent with density increase of self-interstitials and vacancies in the crystal lattice before melting. Self-interstitials and vacancies play a synergic role in the solid–liquid (S-L) transformation. The increase of self-interstitials over a temperature range of about 10 K before melting has the effect of weakening interatomic bonds (modulus drop) that favors the successive vacancy formation. Finally, the huge increase of vacancy concentration above 428 K leads to the collapse of crystal lattice (melting).
Fructose Alters Intermediary Metabolism of Glucose in Human Adipocytes and Diverts Glucose to Serine Oxidation in the One–Carbon Cycle Energy Producing Pathway
Authors: Varma Vijayalakshmi , Boros László , Nolen Greg , Chang Ching-Wei , Wabitsch Martin , Beger Richard , Kaput Jim
Published: June 2015

Increased consumption of sugar and fructose as sweeteners has resulted in the utilization of fructose as an alternative metabolic fuel that may compete with glucose and alter its metabolism. To explore this, human Simpson-Golabi-Behmel Syndrome (SGBS) preadipocytes were differentiated to adipocytes in the presence of 0, 1, 2.5, 5 or 10 mM of fructose added to a medium containing 5 mM of glucose representing the normal blood glucose concentration. Targeted tracer [1,2-13C2]-d-glucose fate association approach was employed to examine the influence of fructose on the intermediary metabolism of glucose. Increasing concentrations of fructose robustly increased the oxidation of [1,2-13C2]-d-glucose to 13CO2 (p < 0.000001). However, glucose-derived 13CO2 negatively correlated with 13C labeled glutamate, 13C palmitate, and M+1 labeled lactate. These are strong markers of limited tricarboxylic acid (TCA) cycle, fatty acid synthesis, pentose cycle fluxes, substrate turnover and NAD+/NADP+ or ATP production from glucose via complete oxidation, indicating diminished mitochondrial energy metabolism. Contrarily, a positive correlation was observed between glucose-derived 13CO2 formed and 13C oleate and doses of fructose which indicate the elongation and desaturation of palmitate to oleate for storage. Collectively, these results suggest that fructose preferentially drives glucose through serine oxidation glycine cleavage (SOGC pathway) one-carbon cycle for NAD+/NADP+ production that is utilized in fructose-induced lipogenesis and storage in adipocytes.
WiFi-Aided Magnetic Matching for Indoor Navigation with Consumer Portable Devices
Authors: Li You , Zhuang Yuan , Lan Haiyu , Zhang Peng , Niu Xiaoji , El-Sheimy Naser
Published: June 2015

This paper presents a WiFi-aided magnetic matching (MM) algorithm for indoor pedestrian navigation with consumer portable devices. This algorithm reduces both the mismatching rate (i.e., the rate of matching to an incorrect point that is more than 20 m away from the true value) and computational load of MM by using WiFi positioning solutions to limit the MM search space. Walking tests with Samsung Galaxy S3 and S4 smartphones in two different indoor environments (i.e., Environment #1 with abundant WiFi APs and significant magnetic features, and Environment #2 with less WiFi and magnetic information) were conducted to evaluate the proposed algorithm. It was found that WiFi fingerprinting accuracy is related to the signal distributions. MM provided results with small fluctuations but had a significant mismatch rate; when aided by WiFi, MM’s robustness was significantly improved. The outcome of this research indicates that WiFi and MM have complementary characteristics as the former is a point-by-point matching approach and the latter is based on profile-matching. Furthermore, performance improvement through integrating WiFi and MM depends on the environment (e.g., the signal distributions of magnetic intensity and WiFi RSS): In Environment #1 tests, WiFi-aided MM and WiFi provided similar results; in Environment #2 tests, the former was approximately 41.6% better. Our results supported that the WiFi-aided MM algorithm provided more reliable solutions than both WiFi and MM in the areas that have poor WiFi signal distribution or indistinctive magnetic-gradient features.
Dynamism of Stimuli-Responsive Nanohybrids: Environmental Implications
Authors: Plazas-Tuttle Jaime , Rowles Lewis , Chen Hao , Bisesi Joseph , Sabo-Attwood Tara , Saleh Navid
Published: June 2015

Nanomaterial science and design have shifted from generating single passive nanoparticles to more complex and adaptive multi-component nanohybrids. These adaptive nanohybrids (ANHs) are designed to simultaneously perform multiple functions, while actively responding to the surrounding environment. ANHs are engineered for use as drug delivery carriers, in tissue-engineered templates and scaffolds, adaptive clothing, smart surface coatings, electrical switches and in platforms for diversified functional applications. Such ANHs are composed of carbonaceous, metallic or polymeric materials with stimuli-responsive soft-layer coatings that enable them to perform such switchable functions. Since ANHs are engineered to dynamically transform under different exposure environments, evaluating their environmental behavior will likely require new approaches. Literature on polymer science has established a knowledge core on stimuli-responsive materials. However, translation of such knowledge to environmental health and safety (EHS) of these ANHs has not yet been realized. It is critical to investigate and categorize the potential hazards of ANHs, because exposure in an unintended or shifting environment could present uncertainty in EHS. This article presents a perspective on EHS evaluation of ANHs, proposes a principle to facilitate their identification for environmental evaluation, outlines a stimuli-based classification for ANHs and discusses emerging properties and dynamic aspects for systematic EHS evaluation.
Validation of Land Cover Products Using Reliability Evaluation Methods
Authors: Shi Wenzhong , Zhang Xiaokang , Hao Ming , Shao Pan , Cai Liping , Lyu Xuzhe
Published: June 2015

Validation of land cover products is a fundamental task prior to data applications. Current validation schemes and methods are, however, suited only for assessing classification accuracy and disregard the reliability of land cover products. The reliability evaluation of land cover products should be undertaken to provide reliable land cover information. In addition, the lack of high-quality reference data often constrains validation and affects the reliability results of land cover products. This study proposes a validation schema to evaluate the reliability of land cover products, including two methods, namely, result reliability evaluation and process reliability evaluation. Result reliability evaluation computes the reliability of land cover products using seven reliability indicators. Process reliability evaluation analyzes the reliability propagation in the data production process to obtain the reliability of land cover products. Fuzzy fault tree analysis is introduced and improved in the reliability analysis of a data production process. Research results show that the proposed reliability evaluation scheme is reasonable and can be applied to validate land cover products. Through the analysis of the seven indicators of result reliability evaluation, more information on land cover can be obtained for strategic decision-making and planning, compared with traditional accuracy assessment methods. Process reliability evaluation without the need for reference data can facilitate the validation and reflect the change trends of reliabilities to some extent.
An Improved Method for Producing High Spatial-Resolution NDVI Time Series Datasets with Multi-Temporal MODIS NDVI Data and Landsat TM/ETM+ Images
Authors: Rao Yuhan , Zhu Xiaolin , Chen Jin , Wang Jianmin
Published: June 2015

Due to technical limitations, it is impossible to have high resolution in both spatial and temporal dimensions for current NDVI datasets. Therefore, several methods are developed to produce high resolution (spatial and temporal) NDVI time-series datasets, which face some limitations including high computation loads and unreasonable assumptions. In this study, an unmixing-based method, NDVI Linear Mixing Growth Model (NDVI-LMGM), is proposed to achieve the goal of accurately and efficiently blending MODIS NDVI time-series data and multi-temporal Landsat TM/ETM+ images. This method firstly unmixes the NDVI temporal changes in MODIS time-series to different land cover types and then uses unmixed NDVI temporal changes to predict Landsat-like NDVI dataset. The test over a forest site shows high accuracy (average difference: −0.0070; average absolute difference: 0.0228; and average absolute relative difference: 4.02%) and computation efficiency of NDVI-LMGM (31 seconds using a personal computer). Experiments over more complex landscape and long-term time-series demonstrated that NDVI-LMGM performs well in each stage of vegetation growing season and is robust in regions with contrasting spatial and spatial variations. Comparisons between NDVI-LMGM and current methods (i.e., Spatial and Temporal Adaptive Reflectance Fusion Model (STARFM), Enhanced STARFM (ESTARFM) and Weighted Linear Model (WLM)) show that NDVI-LMGM is more accurate and efficient than current methods. The proposed method will benefit land surface process research, which requires a dense NDVI time-series dataset with high spatial resolution.
Improved Measurement of Blood Pressure by Extraction of Characteristic Features from the Cuff Oscillometric Waveform
Authors: Lim Pooi , Ng Siew-Cheok , Jassim Wissam , Redmond Stephen , Zilany Mohammad , Avolio Alberto , Lim Einly , Tan Maw , Lovell Nigel
Published: June 2015

We present a novel approach to improve the estimation of systolic (SBP) and diastolic blood pressure (DBP) from oscillometric waveform data using variable characteristic ratios between SBP and DBP with mean arterial pressure (MAP). This was verified in 25 healthy subjects, aged 28 ± 5 years. The multiple linear regression (MLR) and support vector regression (SVR) models were used to examine the relationship between the SBP and the DBP ratio with ten features extracted from the oscillometric waveform envelope (OWE). An automatic algorithm based on relative changes in the cuff pressure and neighbouring oscillometric pulses was proposed to remove outlier points caused by movement artifacts. Substantial reduction in the mean and standard deviation of the blood pressure estimation errors were obtained upon artifact removal. Using the sequential forward floating selection (SFFS) approach, we were able to achieve a significant reduction in the mean and standard deviation of differences between the estimated SBP values and the reference scoring (MLR: mean ± SD = −0.3 ± 5.8 mmHg; SVR and −0.6 ± 5.4 mmHg) with only two features, i.e., Ratio2 and Area3, as compared to the conventional maximum amplitude algorithm (MAA) method (mean ± SD = −1.6 ± 8.6 mmHg). Comparing the performance of both MLR and SVR models, our results showed that the MLR model was able to achieve comparable performance to that of the SVR model despite its simplicity.
Synthesis and Gas Sensing Properties of Single La-Doped SnO2 Nanobelts
Authors: Wu Yuemei , Zhang Heng , Liu Yingkai , Chen Weiwu , Ma Jiang , Li Shuanghui , Qin Zhaojun
Published: June 2015

Single crystal SnO2 nanobelts (SnO2 NBs) and La-SnO2 nanobelts (La-SnO2 NBs) were synthesized by thermal evaporation. Both a single SnO2 NB sensor and a single La-SnO2 NB sensor were developed and their sensing properties were investigated. It is found that the single La-SnO2 NB sensor had a high sensitivity of 8.76 to ethanediol at a concentration of 100 ppm at 230 °C, which is the highest sensitivity of a single SnO2 NB to ethanediol among three kinds of volatile organic (VOC) liquids studied, including ethanediol, ethanol, and acetone. The La-SnO2 NBs sensor also exhibits a high sensitivity, good selectivity and long-term stability with prompt response time to ethanediol. The mechanism behind the enhanced sensing performance of La-doped SnO2 nanobelts is discussed.
Relationship between the Pedaling Biomechanics and Strain of Bicycle Frame during Submaximal Tests
Authors: Manolova Aneliya , Crequy Samuel , Lestriez Philippe , Debraux Pierre , Bertucci William
Published: June 2015

The aim of this study was to analyse the effect of forces applied to pedals and cranks on the strain imposed to an instrumented bicycle motocross (BMX) frame. Using results from a finite element analysis to determine the localisation of highest stress, eight strain gauges were located on the down tube, the seat tube and the right chain stay. Before the pedaling tests, static loads were applied to the frame during bench tests. Two pedaling conditions have been analysed. In the first, the rider was in static standing position on the pedals and applied maximal muscular isometric force to the right pedal. The second pedaling condition corresponds to three pedaling sprint tests at submaximal intensities at 150, 300 and 550 W on a cycle-trainer. The results showed that smaller strain was observed in the pedaling condition than in the rider static standing position condition. The highest strains were located in the seat tube and the right chain stay near the bottom bracket area. The maximum stress observed through all conditions was 41 MPa on the right chain stay. This stress was 11 times lower than the yield stress of the frame material (460 MPa). This protocol could help to adapt the frame design to the riders as a function of their force and mechanical power output. These results could also help design BMX frames for specific populations (females) and rider morphology.
The Unintended Consequences of Technological Change: Winners and Losers from GM Technologies and the Policy Response in the Organic Food Market
Authors: Smyth Stuart , Kerr William , Phillips Peter
Published: June 2015

It is often said that innovations create winners and losers. All innovations are somewhat disruptive, but some have more distributed effects. We have a sense of who the winners are and how much they gain. Yet, how much do losers actually lose? Organic farmers frequently like to publicly announce that they are the losers following the commercialization of genetically modified (GM) crops, yet consumers in search of non-GM products have helped increase demand for organic products, something that would not have occurred in the absence of GM crops. Are organic farmers really losers? This article lays out the argument that were it not for the commercialization of GM crop varieties in the mid-1990s, organic production and food sectors would not be at the level they enjoy today. That is, the commercialization of GM crops has made the organic industry better off than had GM crops not been commercialized. Theoretical modelling of the organic benefits is complemented by supportive market data. The article concludes that in spite of numerous vocal offerings about the adverse impacts suffered by the organic industry due to GM crop production, the organic industry has gained significantly from that which they vociferously criticize.
An Extended Detailed Investigation of First and Second Order Supersymmetries for Off-Shell N = 2 and N = 4 Supermultiplets
Authors: Gates Sylvester , Parker James , Rodgers Vincent , Rodriguez Leo , Stiffler Kory
Published: June 2015

This paper investigates the d = 4, N = 4 Abelian, global Super-Yang Mills system (SUSY-YM). It is shown how the N = 2 Fayet Hypermultiplet (FH) and N = 2 vector multiplet (VM) are embedded within. The central charges and internal symmetries provide a plethora of information as to further symmetries of the Lagrangian. Several of these symmetries are calculated to second order. It is hoped that investigations such as these may yield avenues to help solve the auxiliary field closure problem for d = 4, N = 4, SUSY-YM and the d = 4, N = 2 Fayet-Hypermultiplet, without using an infinite number of auxiliary fields.
Le paysage auvergnat, des Celtes à la Révolution (The landscapes in Auvergne from the Celtic times to 1789)
Authors: Charbonnier Pierre
Published: June 2015

Abstract. - During this whole time the Massif Central was thickly peopled. There were four agricultural ways : rich polyculture, poor polyculture, viticulture, dairycattle breeding in the high mountain grass combined with seasonal cattle movements. Ponds were numerous. Woods were sarce. Their substitutes, waste lands, were used very much for pasture and temprary tillage. At the Celtic and galloro- man times settlement was thick. The invasions of the third and fourth centuries made it to go back. Then clearings went on again under the Merovingians. At the beginning of the fourteenth century settlement was at its summit. At the end of the eighteenth vineyard was winning while wood had been cut down very much.
Le paysage agro-pastoral villageois du Massif Central (The agro-pastoral village landscape in the Massif Central)
Authors: Fel André
Published: June 2015

Résumé. - Recherche de signification d'un vieux paysage : minuscule « village » avec ses terres privées «ouvertes» et sa lande commune. Espace de pauvreté persistante, à l'écart des herbages pastoraux de la vraie montagne comme des terroirs entièrement cultivés des régions basses. Signification agronomique du troupeau commun et curieuse valeur collective d'une micro-société paysanne. Persistance tardive de cette physionomie en plein vingtième siècle.
Paysage, milieu physique et anthropisme (Landscape, physical environment and anthropism)
Authors: Valadas Bernard
Published: June 2015

Abstract. - From two rural landscapes (granitic middle mountain and Grands Causses) the study presents two farmer societies. After showing the elementary units (geomorphology and soil) and their utilization, it has been shown how the agricultural erosion has changed the cultivated slopes as to remodel them ; new physical conditions are so different as before that a new settlement must consider them.