bluuebunny/crossref_metadata_2025 huggingface dataset:
Localized Intrathecal Delivery of Mesenchymal Stromal Cells Conditioned Medium Improves Functional Recovery in a Rat Model of Spinal Cord Injury
Authors: Cizkova Dasa , Cubinkova Veronika , Smolek Tomas , Murgoci Adriana-Natalia , Danko Jan , Vdoviakova Katarina , Humenik Filip , Cizek Milan , Quanico Jusal , Fournier Isabelle , Salzet Michel
Published: March 2018

It was recently shown that the conditioned medium (CM) of mesenchymal stem cells can enhance viability of neural and glial cell populations. In the present study, we have investigated a cell-free approach via CM from rat bone marrow stromal cells (MScCM) applied intrathecally (IT) for spinal cord injury (SCI) recovery in adult rats. Functional in vitro test on dorsal root ganglion (DRG) primary cultures confirmed biological properties of collected MScCM for production of neurosphere-like structures and axon outgrowth. Afterwards, rats underwent SCI and were treated with IT delivery of MScCM or vehicle at postsurgical Days 1, 5, 9, and 13, and left to survive 10 weeks. Rats that received MScCM showed significantly higher motor function recovery, increase in spared spinal cord tissue, enhanced GAP-43 expression and attenuated inflammation in comparison with vehicle-treated rats. Spared tissue around the lesion site was infiltrated with GAP-43-labeled axons at four weeks that gradually decreased at 10 weeks. Finally, a cytokine array performed on spinal cord extracts after MScCM treatment revealed decreased levels of IL-2, IL-6 and TNFα when compared to vehicle group. In conclusion, our results suggest that molecular cocktail found in MScCM is favorable for final neuroregeneration after SCI.
Calorie Restriction Effect of Heat-Processed Onion Extract (ONI) Using In Vitro and In Vivo Animal Models
Authors: Kang Yu-Ri , Choi Hwang-Yong , Lee Jung-Yun , Jang Soo , Kang Hanna , Oh Jung-Bae , Jang Hae-Dong , Kwon Young-In
Published: March 2018

Onion (Allium cepa L.) is widely consumed as food or medicinal plant due to its well-defined health benefits. The antioxidant and antihyperlipidemic effects of onion and its extracts have been reported well. However, very limited information on anti-hyperglycemic effect is available in processed onion extracts. In our previous study, we reported that Amadori rearrangement compounds (ARCs) produced by heat-processing in Korean ginseng can reduce carbohydrate absorption by inhibiting intestinal carbohydrate hydrolyzing enzymes in both in vitro and in vivo animal models. To prove the enhancement of anti-hyperglycemic effect and ARCs content by heat-processing in onion extract, a correlation between the anti-hyperglycemic activity and the total content of ARCs of heat-processed onion extract (ONI) was investigated. ONI has a high content of ARCs and had high rat small intestinal sucrase inhibitory activity (0.34 ± 0.03 mg/mL, IC50) relevant for the potential management of postprandial hyperglycemia. The effect of ONI on the postprandial blood glucose increase was investigated in Sprague Dawley (SD) rats fed on sucrose or starch meals. The maximum blood glucose levels (Cmax) of heat-processed onion extract were significantly decreased by about 8.7% (from 188.60 ± 5.37 to 172.27 ± 3.96, p < 0.001) and 14.2% (from 204.04 ± 8.73 to 175.13 ± 14.09, p < 0.01) in sucrose and starch loading tests, respectively. These results indicate that ARCs in onion extract produced by heat-processing have anti-diabetic effect by suppressing carbohydrate absorption via inhibition of intestinal sucrase, thereby reducing the postprandial increase of blood glucose. Therefore, enhancement of ARCs in onion by heat-processing might be a good strategy for the development of the new product on the management of hyperglycemia.
Spider Communities and Biological Control in Native Habitats Surrounding Greenhouses
Authors: Cotes Belén , González Mónica , Benítez Emilio , De Mas Eva , Clemente-Orta Gemma , Campos Mercedes , Rodríguez Estefanía
Published: March 2018

The promotion of native vegetation as a habitat for natural enemies, which could increase their abundance and fitness, is especially useful in highly simplified settings such as Mediterranean greenhouse landscapes. Spiders as generalist predators may also be involved in intra-guild predation. However, the niche complementarity provided by spiders as a group means that increased spider diversity may facilitate complementary control actions. In this study, the interactions between spiders, the two major horticultural pests, Bemisia tabaci and Frankliniella occidentalis, and their naturally occurring predators and parasitoids were evaluated in a mix of 21 newly planted shrubs selected for habitat management in a highly disturbed horticultural system. The effects of all factors were evaluated using redundancy analysis (RDA) and the generalized additive model (GAM) to assess the statistical significance of abundance of spiders and pests. The GAM showed that the abundance of both pests had a significant effect on hunter spider’s abundance, whereas the abundance of B. tabaci, but not F. occidentalis, affected web-weavers’ abundance. Ordination analysis showed that spider abundance closely correlated with that of B. tabaci but not with that of F. occidentalis, suggesting that complementarity occurs, and thereby probability of biocontrol, with respect to the targeted pest B. tabaci, although the temporal patterns of the spiders differed from those of F. occidentalis. Conservation strategies involving the establishment of these native plants around greenhouses could be an effective way to reduce pest populations outdoors.
Applications of Open Source GMAW-Based Metal 3-D Printing
Authors: Nilsiam Yuenyong , Sanders Paul , Pearce Joshua
Published: March 2018

The metal 3-D printing market is currently dominated by high-end applications, which make it inaccessible for small and medium enterprises, fab labs, and individual makers who are interested in the ability to prototype and additively manufacture final products in metal. Recent progress led to low-cost open-source metal 3-D printers using a gas metal arc welding (GMAW)-based print head. This reduced the cost of metal 3-D printers into the range of desktop prosumer polymer 3-D printers. Consequent research established good material properties of metal 3-D printed parts with readily-available weld filler wire, reusable substrates, thermal and stress properties, toolpath planning, bead-width control, mechanical properties, and support for overhangs. These previous works showed that GMAW-based metal 3-D printing has a good adhesion between layers and is not porous inside the printed parts, but they did not proceed far enough to demonstrate applications. In this study, the utility of the GMAW approach to 3-D printing is investigated using a low-cost open-source metal 3-D printer and a converted Computer Numerical Control router machine to make useful parts over a range of applications including: fixing an existing part by adding a 3-D metal feature, creating a product using the substrate as part of the component, 3-D printing in high resolution of useful objects, near net objects, and making an integrated product using a combination of steel and polymer 3-D printing. The results show that GMAW-based 3-D printing is capable of distributed manufacturing of useful products for a wide variety of applications for sustainable development.
A Study on the Microstructural Evolution of a Low Alloy Steel by Different Shot Peening Treatments
Authors: González Juan , Peral Luis-Borja , Colombo Chiara , Fernández Pariente Ines
Published: March 2018

Recent studies have shown that severe shot peening can be categorized as a severe plastic deformation surface treatment that is able to strongly modify the microstructure of the surface layer of materials, by both increasing the dislocation density and introducing a large number of defects that define new grain boundaries and form ultrafine structure. In this work, conventional shot peening and severe shot peening treatments were applied to 39NiCrMo3 steel samples. The samples were characterized in terms of microstructure, surface roughness, microhardness, residual stresses, and surface work-hardening as a function of surface coverage. Particular attention was focused on the analysis of the microstructure to assess the evolution of grain size from the surface to the inner material to capture the gradient microstructure. Severe shot peening proved to cause a more remarkable improvement of the general mechanical characteristics compared to conventional shot peening; more significant improvement was associated with the microstructural alteration induced by the treatment. Our datas provide a detailed verification of the relationship between shot peening treatment parameters and the microstructure evolution from the treated surface to the core material.
Nanoparticle-Assisted Metabolomics
Authors: Zhang Bo , Xie Mouzhe , Bruschweiler-Li Lei , Brüschweiler Rafael
Published: March 2018

Understanding and harnessing the interactions between nanoparticles and biological molecules is at the forefront of applications of nanotechnology to modern biology. Metabolomics has emerged as a prominent player in systems biology as a complement to genomics, transcriptomics and proteomics. Its focus is the systematic study of metabolite identities and concentration changes in living systems. Despite significant progress over the recent past, important challenges in metabolomics remain, such as the deconvolution of the spectra of complex mixtures with strong overlaps, the sensitive detection of metabolites at low abundance, unambiguous identification of known metabolites, structure determination of unknown metabolites and standardized sample preparation for quantitative comparisons. Recent research has demonstrated that some of these challenges can be substantially alleviated with the help of nanoscience. Nanoparticles in particular have found applications in various areas of bioanalytical chemistry and metabolomics. Their chemical surface properties and increased surface-to-volume ratio endows them with a broad range of binding affinities to biomacromolecules and metabolites. The specific interactions of nanoparticles with metabolites or biomacromolecules help, for example, simplify metabolomics spectra, improve the ionization efficiency for mass spectrometry or reveal relationships between spectral signals that belong to the same molecule. Lessons learned from nanoparticle-assisted metabolomics may also benefit other emerging areas, such as nanotoxicity and nanopharmaceutics.
Comparison of Multiple Bioactive Constituents in Different Parts of Eucommia ulmoides Based on UFLC-QTRAP-MS/MS Combined with PCA
Authors: Yan Ying , Zhao Hui , Chen Cuihua , Zou Lisi , Liu Xunhong , Chai Chuan , Wang Chengcheng , Shi Jingjing , Chen Shuyu
Published: March 2018

Eucommia ulmoides Oilv. (EU), also called Du-zhong, is a classical traditional Chinese medicine. Its bark, leaf, and male flower are all used for medicinal purposes, called Eucommiae Cortex (EC), Eucommiae Folium (EF), and Eucommiae Flos Male (EFM). In order to study the difference in synthesis and the accumulation of metabolites in different parts of EU, a reliable method based on ultra-fast liquid chromatography tandem triple quadrupole mass spectrometry (UFLC-QTRAP-MS/MS) was developed for the simultaneous determination of a total of 21 constituents, including two lignans, 6 iridoids, 6 penylpropanoids, 6 flavonoids, and one phenol in the samples (EC, EF, and EFM). Furthermore, principal component analysis (PCA) was performed to evaluate and classify the samples according to the contents of these 21 constituents. All of the results demonstrated that the chemical compositions in EC, EF, and EFM were significantly different and the differential constituents (i.e., aucubin, geniposidic acid, chlorogenic acid, pinoresinol-di-O-β-d-glucopyranoside, geniposide, cryptochlorogenic acid, rutin, and quercetin) were remarkably associated with sample classifications. The research will provide the basic information for revealing the laws of metabolite accumulation in EC, EF, and EFM from the same origin.
Ruthenium(η6,η1-arene-CH2-NHC) Catalysts for Direct Arylation of 2-Phenylpyridine with (Hetero)Aryl Chlorides in Water
Authors: Kaloğlu Nazan , Özdemir İsmail , Gürbüz Nevin , Arslan Hakan , Dixneuf Pierre
Published: March 2018

A series of new benzimidazolium halides were synthesized in good yields as unsymmetrical N-heterocyclic carbene (NHC) precursors containing the N–CH2–arene group. The benzimidazolium halides were readily converted into ruthenium(II)–NHC complexes with the general formula [RuCl2(η6,η1–arene–CH2–NHC)]. The structures of all new compounds were characterized by 1H NMR (Nuclear Magnetic Resonance), 13C NMR, FT-IR (Fourier Transform Infrared) spectroscopy and elemental analysis techniques. The single crystal structure of one benzimidazole ruthenium complex, 2b, was determined. The complex is best thought of as containing an octahedrally coordinated Ru center with the arene residue occupying three sites, the remaining sites being occupied by a (carbene)C–Ru bond and two Ru–Cl bonds. The catalytic activity of [RuCl2(η6,η1–arene–CH2–NHC)] complexes was evaluated in the direct (hetero)arylation of 2-phenylpyridine with (hetero)aryl chlorides in water as the nontoxic reaction medium. These results show that catalysts 2a and 2b were the best for monoarylation with simple phenyl and tolyl chlorides. For functional aryl chlorides, 2d, 2e, and 2c appeared to be the most efficient.
A Green Protocol for Microwave-Assisted Extraction of Volatile Oil Terpenes from Pterodon emarginatus Vogel. (Fabaceae)
Authors: Vila Verde Giuliana M. , Barros Diogo A. , Oliveira Marilene , Aquino Gilberto , M. Santos Danilo , De Paula José , Dias Lucas , Piñeiro Marta , M. Pereira Mariette
Published: March 2018

Microwave-assisted extraction of volatile oils (MAE) potentially offers a more efficient and bio-sustainable method than conventional extraction by Clevenger apparatus (CE). This study aimed to optimise the MAE of the volatile oil from Pterodon emarginatus fruits and characterise the volatile compounds. A 23 full-factorial central composite design and response surface methodology were used to evaluate the effects of time (min), moisture (%) and microwave power (W) on the extraction yield. The process optimisation was based on the desirability function approach. The reaction time and moisture conditions were standardised in these analyses. The volatile oil composition was analysed by Gas Chromatography/Mass Spectrometry (GC/MS) in order to compare techniques extractions influences. Microwave irradiation showed excellent performance for extraction of the volatile oil from Pterodon emarginatus and there were some advantages in compare to conventional method with respect to the time (14 times), energy (6 times), reagents amounts and waste formation. About chemical composition presents significant differences with the type of extraction. Caryophyllene (25.65%) and trans-α-bisabolol (6.24%) were identified as major components in MAE sample while caryophyllene (6.75%) and γ-elemene (7.02%) are the components with higher relative percentage in CE samples. The microwaves assisted process shown an increase of economic interested compounds present in volatile oil.
Recent Advances in Modified Cellulose for Tissue Culture Applications
Authors: Courtenay James , Sharma Ram , Scott Janet
Published: March 2018

Tissue engineering is a rapidly advancing field in regenerative medicine, with much research directed towards the production of new biomaterial scaffolds with tailored properties to generate functional tissue for specific applications. Recently, principles of sustainability, eco-efficiency and green chemistry have begun to guide the development of a new generation of materials, such as cellulose, as an alternative to conventional polymers based on conversion of fossil carbon (e.g., oil) and finding technologies to reduce the use of animal and human derived biomolecules (e.g., foetal bovine serum). Much of this focus on cellulose is due to it possessing the necessary properties for tissue engineering scaffolds, including biocompatibility, and the relative ease with which its characteristics can be tuned through chemical modification to adjust mechanical properties and to introduce various surface modifications. In addition, the sustainability of producing and manufacturing materials from cellulose, as well as its modest cost, makes cellulose an economically viable feedstock. This review focusses specifically on the use of modified cellulose materials for tissue culturing applications. We will investigate recent techniques used to promote scaffold function through physical, biochemical and chemical scaffold modifications, and describe how these have been utilised to reduce reliance on the addition of matrix ligands such as foetal bovine serum.
The Ubiquitin-Conjugating Enzyme Gene Family in Longan (Dimocarpus longan Lour.): Genome-Wide Identification and Gene Expression during Flower Induction and Abiotic Stress Responses
Authors: Jue Dengwei , Sang Xuelian , Liu Liqin , Shu Bo , Wang Yicheng , Xie Jianghui , Liu Chengming , Shi Shengyou
Published: March 2018

Ubiquitin-conjugating enzymes (E2s or UBC enzymes) play vital roles in plant development and combat various biotic and abiotic stresses. Longan (Dimocarpus longan Lour.) is an important fruit tree in the subtropical region of Southeast Asia and Australia; however the characteristics of the UBC gene family in longan remain unknown. In this study, 40 D. longan UBC genes (DlUBCs), which were classified into 15 groups, were identified in the longan genome. An RNA-seq based analysis showed that DlUBCs showed distinct expression in nine longan tissues. Genome-wide RNA-seq and qRT-PCR based gene expression analysis revealed that 11 DlUBCs were up- or down-regualted in the cultivar “Sijimi” (SJ), suggesting that these genes may be important for flower induction. Finally, qRT-PCR analysis showed that the mRNA levels of 13 DlUBCs under SA (salicylic acid) treatment, seven under methyl jasmonate (MeJA) treatment, 27 under heat treatment, and 16 under cold treatment were up- or down-regulated, respectively. These results indicated that the DlUBCs may play important roles in responses to abiotic stresses. Taken together, our results provide a comprehensive insight into the organization, phylogeny, and expression patterns of the longan UBC genes, and therefore contribute to the greater understanding of their biological roles in longan.
Silyl Ketene Acetals/B(C6F5)3 Lewis Pair-Catalyzed Living Group Transfer Polymerization of Renewable Cyclic Acrylic Monomers
Authors: Hu Lu , Zhao Wuchao , He Jianghua , Zhang Yuetao
Published: March 2018

This work reveals the silyl ketene acetal (SKA)/B(C6F5)3 Lewis pair-catalyzed room-temperature group transfer polymerization (GTP) of polar acrylic monomers, including methyl linear methacrylate (MMA), and the biorenewable cyclic monomers γ-methyl-α-methylene-γ-butyrolactone (MMBL) and α-methylene-γ-butyrolactone (MBL) as well. The in situ NMR monitored reaction of SKA with B(C6F5)3 indicated the formation of Frustrated Lewis Pairs (FLPs), although it is sluggish for MMA polymerization, such a FLP system exhibits highly activity and living GTP of MMBL and MBL. Detailed investigations, including the characterization of key reaction intermediates, polymerization kinetics and polymer structures have led to a polymerization mechanism, in which the polymerization is initiated with an intermolecular Michael addition of the ester enolate group of SKA to the vinyl group of B(C6F5)3-activated monomer, while the silyl group is transferred to the carbonyl group of the B(C6F5)3-activated monomer to generate the single-monomer-addition species or the active propagating species; the coordinated B(C6F5)3 is released to the incoming monomer, followed by repeated intermolecular Michael additions in the subsequent propagation cycle. Such neutral SKA analogues are the real active species for the polymerization and are retained in the whole process as confirmed by experimental data and the chain-end analysis by matrix-assisted laser desorption/ionization time of flight mass spectroscopy (MALDI-TOF MS). Moreover, using this method, we have successfully synthesized well-defined PMMBL-b-PMBL, PMMBL-b-PMBL-b-PMMBL and random copolymers with the predicated molecular weights (Mn) and narrow molecular weight distribution (MWD).
Synthesis of New C- and N-β-d-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase
Authors: Kun Sándor , Bokor Éva , Sipos Ádám , Docsa Tibor , Somsák László
Published: March 2018

The aim of the present study was to broaden the structure-activity relationships of C- and N-β-d-glucopyranosyl azole type inhibitors of glycogen phosphorylase. 1-Aryl-4-β-d-gluco-pyranosyl-1,2,3-triazoles were prepared by copper catalyzed azide-alkyne cycloadditions between O-perbenzylated or O-peracetylated β-d-glucopyranosyl ethynes and aryl azides. 1-β-d-Gluco-pyranosyl-4-phenyl imidazole was obtained in a glycosylation of 4(5)-phenylimidazole with O-peracetylated α-d-glucopyranosyl bromide. C-β-d-Glucopyranosyl-N-substituted-tetrazoles were synthesized by alkylation/arylation of O-perbenzoylated 5-β-d-glucopyranosyl-tetrazole or from a 2,6-anhydroheptose tosylhydrazone and arenediazonium salts. 5-Substituted tetrazoles were glycosylated by O-peracetylated α-d-glucopyranosyl bromide to give N-β-d-glucopyranosyl-C-substituted-tetrazoles. Standard deprotections gave test compounds which were assayed against rabbit muscle glycogen phosphorylase b. Most of the compounds proved inactive, the best inhibitor was 2-β-d-glucopyranosyl-5-phenyltetrazole (IC50 600 μM). These studies extended the structure-activity relationships of β-d-glucopyranosyl azole type inhibitors and revealed the extreme sensitivity of such type of inhibitors towards the structure of the azole moiety.
Antioxidant and Neuroprotective Effects of N-((3,4-Dihydro-2H-benzo[h]chromen-2-yl)methyl)-4-methoxyaniline in Primary Cultured Rat Cortical Cells: Involvement of ERK-CREB Signaling
Authors: Lee Kyeongjun , Park Chowee , Oh Yeonsoo , Lee Heesoon , Cho Jungsook
Published: March 2018

Excitotoxicity and oxidative stress play vital roles in the development of neurodegenerative disorders including Alzheimer’s disease (AD). In the present study, we investigated the effect of N-((3,4-dihydro-2H-benzo[h]chromen-2-yl)methyl)-4-methoxyaniline (BL-M) on excitotoxic neuronal cell damage in primary cultured rat cortical cells, and compared to that of memantine, a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist clinically used to treat AD. We found that BL-M inhibited glutamate- or N-methyl-d-aspartate (NMDA)-induced excitotoxic cell damage. The IC50 value of BL-M against NMDA toxicity was comparable to that of memantine. BL-M potently inhibited intracellular reactive oxygen species generated by glutamate or NMDA. Additionally, it inhibited the formation of 1,1-diphenyl-2-picryl-hydrazyl radicals in vitro and lipid peroxidation in rat brain homogenates. In contrast, memantine showed minimal or negligible antioxidant activity. Western blotting and immunocytochemical analyses showed that BL-M, not memantine, increased the ERK1/2 phosphorylation and subsequent phosphorylation of cAMP response element-binding protein (CREB). The inhibition of NMDA toxicity by BL-M was dramatically reversed by U0126, a well-known MEK inhibitor, suggesting that ERK1/2-mediated CREB phosphorylation is required for the neuroprotective action. Collectively, in this study, we demonstrated the neuroprotective effect of a newly synthesized chromene derivative BL-M and its underlying action mechanism(s). In contrast to memantine, BL-M exhibited marked antioxidant activity. Furthermore, it enhanced the ERK-mediated phosphorylation of CREB, which plays a crucial neuroprotective role. Our findings suggest that BL-M may be beneficial for AD and other neurodegenerative disorders associated with excitotoxicity as well as oxidative stress.
Cooperation between NMDA-Type Glutamate and P2 Receptors for Neuroprotection during Stroke: Combining Astrocyte and Neuronal Protection
Authors: Vermehren Philipp , Trotman-Lucas Melissa , Hechler Beatrice , Gachet Christian , Evans Richard , Gibson Claire , Fern Robert
Published: March 2018

Excitotoxicity is the principle mechanism of acute injury during stroke. It is defined as the unregulated accumulation of excitatory neurotransmitters such as glutamate within the extracellular space, leading to over-activation of receptors, ionic disruption, cell swelling, cytotoxic Ca2+ elevation and a feed-forward loop where membrane depolarisation evokes further neurotransmitter release. Glutamate-mediated excitotoxicity is well documented in neurons and oligodendrocytes but drugs targeting glutamate excitotoxicity have failed clinically which may be due to their inability to protect astrocytes. Astrocytes make up ~50% of the brain volume and express high levels of P2 adenosine triphosphate (ATP)-receptors which have excitotoxic potential, suggesting that glutamate and ATP may mediate parallel excitotoxic cascades in neurons and astrocytes, respectively. Mono-cultures of astrocytes expressed an array of P2X and P2Y receptors can produce large rises in [Ca2+]i; mono-cultured neurons showed lower levels of functional P2 receptors. Using high-density 1:1 neuron:astrocyte co-cultures, ischemia (modelled as oxygen-glucose deprivation: OGD) evoked a rise in extracellular ATP, while P2 blockers were highly protective of both cell types. GluR blockers were only protective of neurons. Neither astrocyte nor neuronal mono-cultures showed significant ATP release during OGD, showing that cell type interactions are required for ischemic release. P2 blockers were also protective in normal-density co-cultures, while low doses of combined P2/GluR blockers where highly protective. These results highlight the potential of combined P2/GluR block for protection of neurons and glia.
Walking Meditation: Being Present and Being Pilgrim on the Camino de Santiago
Authors: Smith Alison
Published: March 2018

The Camino de Santiago has witnessed an unprecedented number of walkers in recent years. Traditionalists feel that the Camino is suffering from excess—too many visitors and too much strain on the infrastructure, accompanied by an ignorance of what it means to be an “authentic” pilgrim. Contemporary pilgrims often use ancillary services to transport their bags, approaching the Camino as an athletic event or a holiday excursion. For scholars and people of faith, these superficial attitudes to the ancient pilgrimage route are disturbing. How can serious pilgrims make peace with those who have neither the historical nor the religious background to understand the magnitude of their endeavor? Vietnamese Zen master and peace activist Thich Nhat Hahn offers us the practice of walking meditation as a means of being present. I believe that pilgrims can benefit from studying the principles of walking meditation as it is observed in the Buddhist tradition. Pilgrims of all faiths and backgrounds can make use of Thich Nhat Hahn’s practice to enhance their experience. Travelers who incorporate the custom of walking meditation may find common ground. Certainly, those who choose to do walking meditation while on pilgrimage will be more mindful of their journey.
3VSR: Three Valued Secure Routing for Vehicular Ad Hoc Networks using Sensing Logic in Adversarial Environment
Authors: Sohail Muhammad , Wang Liangmin
Published: March 2018

Today IoT integrate thousands of inter networks and sensing devices e.g., vehicular networks, which are considered to be challenging due to its high speed and network dynamics. The goal of future vehicular networks is to improve road safety, promote commercial or infotainment products and to reduce the traffic accidents. All these applications are based on the information exchange among nodes, so not only reliable data delivery but also the authenticity and credibility of the data itself are prerequisite. To cope with the aforementioned problem, trust management come up as promising candidate to conduct node’s transaction and interaction management, which requires distributed mobile nodes cooperation for achieving design goals. In this paper, we propose a trust-based routing protocol i.e., 3VSR (Three Valued Secure Routing), which extends the widely used AODV (Ad hoc On-demand Distance Vector) routing protocol and employs the idea of Sensing Logic-based trust model to enhance the security solution of VANET (Vehicular Ad-Hoc Network). The existing routing protocol are mostly based on key or signature-based schemes, which off course increases computation overhead. In our proposed 3VSR, trust among entities is updated frequently by means of opinion derived from sensing logic due to vehicles random topologies. In 3VSR the theoretical capabilities are based on Dirichlet distribution by considering prior and posterior uncertainty of the said event. Also by using trust recommendation message exchange, nodes are able to reduce computation and routing overhead. The simulated results shows that the proposed scheme is secure and practical.
Context Mining of Sedentary Behaviour for Promoting Self-Awareness Using a Smartphone
Authors: Fahim Muhammad , Baker Thar , Khattak Asad , Shah Babar , Aleem Saiqa , Chow Francis
Published: March 2018

Sedentary behaviour is increasing due to societal changes and is related to prolonged periods of sitting. There is sufficient evidence proving that sedentary behaviour has a negative impact on people’s health and wellness. This paper presents our research findings on how to mine the temporal contexts of sedentary behaviour by utilizing the on-board sensors of a smartphone. We use the accelerometer sensor of the smartphone to recognize user situations (i.e., still or active). If our model confirms that the user context is still, then there is a high probability of being sedentary. Then, we process the environmental sound to recognize the micro-context, such as working on a computer or watching television during leisure time. Our goal is to reduce sedentary behaviour by suggesting preventive interventions to take short breaks during prolonged sitting to be more active. We achieve this goal by providing the visualization to the user, who wants to monitor his/her sedentary behaviour to reduce unhealthy routines for self-management purposes. The main contribution of this paper is two-fold: (i) an initial implementation of the proposed framework supporting real-time context identification; (ii) testing and evaluation of the framework, which suggest that our application is capable of substantially reducing sedentary behaviour and assisting users to be active.
Non-Contact Respiration Measurement during Exercise Tolerance Test by Using Kinect Sensor
Authors: Aoki Hirooki , Nakamura Hidetoshi
Published: March 2018

This study aims to assess non-contact respiration measurement during the exercise stress test using an upright bicycle ergometer and to evaluate the ventilation threshold value. We propose the tracking of the chest and abdomen by applying the motion capture function of the Kinect V2 sensor to cope with an increase in physical exercise accompanied by an increase in exercise intensity. In the proposed method, the region enclosed by the four joints corresponding to the left and right shoulders and the right and left hip extracted using the Kinect sensor is set as the region of interest. The region is updated in response to changes in body movements. By extracting the signal of the pedaling frequency component from the time series data of the volume in the region, only the volume change due to respiration was extracted. The point at which the increased rate of the volume change elevates is estimated as the ventilation threshold. The assessment of the efficacy of the proposed method by comparative analysis using an expiration gas analyzer confirmed that non-contact respiration evaluation is possible with an exercise intensity of about 160 W. Furthermore, the ventilation threshold estimated by the proposed method is ±10 W of the estimated value by expiratory gas analyzer.
Carbon Chemistry in the Mainstream of Kuroshio Current in Eastern Taiwan and Its Transport of Carbon into the East China Sea Shelf
Authors: Qu Baoxiao , Song Jinming , Yuan Huamao , Li Xuegang , Li Ning
Published: March 2018

Comprehensive carbon chemistry data were measured from the mainstream of Kuroshio, off eastern Taiwan, in May 2014. Results indicated that variations of pH@25 °C, POC, ΩCa, DIC, pCO2 and RF were closely related to the characteristics of various water types. Phytoplankton photosynthesis played important roles in DIC variation in Kuroshio Surface Water (KSW), whereas the DIC variation in Kuroshio Subsurface Water (KSSW) was probably influenced by the external transport of DIC-enriched water from the South China Sea. Vertical profiles of hydrological parameters and carbonate species indicated that the Kuroshio Current off eastern Taiwan could intrude into the ECS shelf as far as 27.9° E, 125.5° N in spring. What is more, the KSW, KSSW and Kuroshio Intermediate Water (KIW) could convey DIC into the East China Sea (ECS) with flux of 285, 305 and 112 Tg C/half year (1 Tg = 1012 g), respectively. The relevant flux of POC was 0.16, 2.93 and 0.04 Tg C/half year, respectively. Consequently, the intrusion of Kuroshio could probably exert a counteracting influence on the potential of CO2 uptake in the ECS, which needs further study.
Parametric Assessment of Pre-Monsoon Agricultural Water Scarcity in Bangladesh
Authors: Ahammed Sumaiya , Chung Eun-Sung , Shahid Shamsuddin
Published: March 2018

This study assesses the geographical distribution of agricultural water scarcity in Bangladesh in order to streamline the adaptation measures. The agricultural water scarcity was assumed to be a system with five subsystems, namely, groundwater depth, surface water availability, rainfall availability, groundwater salinity for irrigation, and surface water salinity for irrigation. The catastrophe-theory-based multi-criteria decision making approach was used for the estimation of agricultural water scarcity index from five subsystem indices. The obtained results showed that agriculture in about 6.3% of the area of the country is experiencing very high-risk water scarcity, 19.1% with high water scarcity, 37.2% with moderate water risk, and the rest is low or no risk of water scarcity for agriculture. Results showed that the western part of Bangladesh was more vulnerable to agricultural water scarcity. The analysis of the results showed that higher agriculture water scarcity in the northwest region resulted from water unavailability, and in the southwest region it was closely related to poor water quality. The severe areas of water scarcity are very similar to those that are usually regarded as water-scarce. The approach presented in this study can be used for rapid but fair assessment of water scarcity with readily available data, which can be further improved by incorporating other factors related to water scarcity.
Shifting Scarcities? The Energy Intensity of Water Supply Alternatives in the Mass Tourist Resort of Benidorm, Spain
Authors: Yoon Hyerim , Sauri David , Rico Amorós Antonio
Published: March 2018

The energy intensity of water—‘energy (electricity)-for-water’—is calculated for Benidorm, a mass tourism resort in the Spanish Mediterranean coast, where the urban water cycle has evolved in response to a series of episodes of water stress. The analysis is based on primary data compiled from various actors involved in the urban water cycle encompassing water extraction, end uses, and wastewater treatment, including tertiary treatment. The results provide one of the first analyses of the relations between energy and water in a mass tourist center, which may be of potential interest for other tourist areas. It is estimated that a total of 109 GWh/year of electricity is required to operate the water cycle of Benidorm. About 4% of total energy use in Benidorm is dedicated to extracting, transporting, and treating water. The most energy-intensive stage is represented by end uses, which accounts for 20% of the total energy use in Benidorm when the energy required for water pumping and hot water use is considered. Additionally, energy intensity for water extraction was estimated for normal, wet, and two dry year scenarios. In comparison with the normal scenario, energy intensity is six times larger when desalinated water is incorporated during a dry year, whereas the emergency interbasin water transfer resulted in a more moderate increase in energy intensity. While treated wastewater and emergency water transfers appear to be a more convenient solution in energy terms, the strong impulse given to desalination in Spain is forcing local water authorities towards the use of a resource that is much more energy intensive, although, on the other hand, much less dependent on the vagaries of climate. In light of recent technological and managerial developments, the Benidorm case illuminates the challenges appearing in the analysis of the water-energy nexus, especially the fact that scarcity may be transferred from water to energy.
Traditional and Local Knowledge Practices for Disaster Risk Reduction in Northern Ghana
Authors: Macnight Ngwese Nsioh , Saito Osamu , Sato Akiko , Agyeman Boafo Yaw , Jasaw Godfred
Published: March 2018

In order to deal with recurrent disasters, like floods and droughts coupled with the limited adaptive capacity, in the semiarid regions of Northern Ghana, local communities have no choice but to apply traditional and local knowledge practices. This study seeks to identify such practices employed in selected rural communities in Northern Ghana and to investigate their effectiveness. Data were collected through key informant interviews, household questionnaire surveys, focus group discussions, and participant observations. The findings indicated that although diverse practices were applied to predict and manage local disaster events, skepticism prevailed among locals toward these practices regarding their effectiveness. Due to the lack of science-based tools and systems for disaster prediction and management, local communities continually depended on these knowledge systems and practices. Integrating local and traditional disaster risk reduction (DRR) efforts into modern scientific knowledge should be encouraged in order to reduce the vulnerability of local communities to disasters with thorough effectiveness evaluation protocols.
Anthropogenic Impact on Erosion Intensity: Case Study of Rural Areas of Pirot and Dimitrovgrad Municipalities, Serbia
Authors: Manojlović Sanja , Antić Marija , Šantić Danica , Sibinović Mikica , Carević Ivana , Srejić Tanja
Published: March 2018

In many Eastern European countries, the standard of living increased as a result of the process of industrialization in the second half of the 20th Century. Consequently, the population in rural areas with small-scale farming decreased due to the availability of employment elsewhere. This directly impacted soil erosion (and thereby sustainability of the land), but the degree and direction are not well known. This study investigates two municipalities within Serbia, their change in population and its impact on land use changes and soil erosion. The standard of living increased after the industrialization process in the 1960s within these municipalities. The erosion potential model is used to calculate gross annual erosion. The changes related to population and arable land in rural settlements are analyzed according to proportional spatial changes. The results show an overall decrease of erosion intensity in the study area. In addition, two basic findings are derived: first, the highest level of human impact on soil is in rural settlements at the lowest elevation zones, where erosion intensity shows the least amount of decrease; and, second, the most intensive depopulation process, recorded in higher elevation zones, indicates a rapid decrease of erosion intensity.
Spatial Pattern of Residential Carbon Dioxide Emissions in a Rapidly Urbanizing Chinese City and Its Mismatch Effect
Authors: Lu Heli , Liu Guifang , Miao Changhong , Zhang Chuanrong , Cui Yaoping , Zhao Jincai
Published: March 2018

Cities undergoing rapid urbanization are characterized by quick successions of spatiotemporal patterns, meaning that traditional methods cannot adequately assess carbon emissions from urban residential areas, which prevents the study of spatial mismatch. Therefore, this study utilizes night-time lights to construct a spatial emissions model that enables the analysis of the evolution of emissions patterns in China. The results indicate that, compared to the traditional method, the spatial modeling based on night-time lights reflects the spatial emissions trajectories in a more timely and accurate manner in rapidly urbanizing cities. Additionally, we found a relatively low degree of spatial match between emissions and economic activities, with the former, which are greatly affected by urbanization, having a larger dynamism and instability than the latter. Such spatial mismatch effect illustrates that policy makers should focus on factors beyond economics in order to reduce residential carbon emissions during China’s rapid urbanization process.
On the Architecture of Systemology and the Typology of Its Principles
Authors: Rousseau David
Published: March 2018

Systems engineering is increasingly challenged by the rising complexity of projects undertaken, resulting in increases in costs, failure rates, and negative unintended consequences. This has resulted in calls for more scientific principles to underpin the methods of systems engineering. In this paper, it is argued that our ability to improve systems Engineering’s methods depends on making the principles of systemology, of which systems engineering is a part, more diverse and more scientific. An architecture for systemology is introduced, which shows how the principles of systemology arise from interdependent processes spanning multiple disciplinary fields, and on this basis a typology is introduced, which can be used to classify systems principles and systems methods. This framework, consisting of an architecture and a typology, can be used to survey and classify the principles and methods currently in use in systemology, map vocabularies referring to them, identify key gaps, and expose opportunities for further development. It may, thus, serve as a tool for coordinating collaborative work towards advancing the scope and depth of systemology.
The short-a split in a suburban area of the New York City dialect region
Authors: Shapp Allison
Published: March 2018

In American English, the most common pattern for the pronunciation of the allophones of the vowel phoneme /æ/ is the “nasal-split,” where the vowel is tense (raised, fronted) when followed by a nasal consonant and lax (lowered, backed) otherwise. In contrast, historically New York City English (NYCE) has had a “complex short-a split” with different conditioning factors for each allophone. This paper reports on new data from the eastern edge of the NYCE dialect region: suburban Nassau County, Long Island. Using word-list data from the sociolinguistic interviews of 24 high school students, aged 14-18, and 7 of their teachers and mentors, this paper shows that while young speakers in this region are moving towards the wider American nasal-split, the local version of that nasal-split still includes components of the traditional NYCE complex-split.
Constraints on Metal Oxide and Metal Hydroxide Abundances in the Winds of AGB Stars: Potential Detection of FeO in R Dor
Authors: Decin L. , Danilovich T. , Gobrecht D. , Plane J. M. C. , Richards A. M. S. , Gottlieb C. A. , Lee K. L. K.
Published: March 2018

Using the Atacama Large Millimeter/submillimeter Array (ALMA), we observed the stellar wind of two oxygen-rich asymptotic giant branch stars, IK Tau and R Dor, between 335 and 362 GHz. One aim was to detect metal oxides and metal hydroxides (AlO, AlOH, FeO, MgO, and MgOH), some of which are thought to be direct precursors of dust nucleation and growth. We report on the potential first detection of FeO (v = 0, Ω = 4, J = 11–10) in R Dor (mass-loss rate

∼ 1 × 10−7
M
⊙ yr−1). The presence of FeO in IK Tau (

∼ 5 × 10−6
M
⊙ yr−1) cannot be confirmed, due to a blend with 29SiS, a molecule that is absent in R Dor. The detection of AlO in R Dor and of AlOH in IK Tau was reported earlier by Decin et al. All other metal oxides and hydroxides, as well as MgS, remain undetected. We derive a column density N(FeO) of 1.1 ± 0.9 × 1015 cm−2 in R Dor, or a fractional abundance [FeO/H] ∼ 1.5 × 10−8 accounting for non-local thermodynamic equilibrium effects. The derived fractional abundance [FeO/H] is a factor ∼20 larger than conventional gas-phase chemical-kinetic predictions. This discrepancy may be partly accounted for by the role of vibrationally excited OH in oxidizing Fe, or it may be evidence for other currently unrecognized chemical pathways producing FeO. Assuming a constant fractional abundance w.r.t. H2, the upper limits for the other metals are [MgO/H2] < 5.5 × 10−10 (R Dor) and <7 × 10−11 (IK Tau), [MgOH/H2] < 9 × 10−9 (R Dor) and <1 × 10−9 (IK Tau), [CaO/H2] < 2.5 × 10−9 (R Dor) and <1 × 10−10 (IK Tau), [CaOH/H2] < 6.5 × 10−9 (R Dor) and <9 × 10−10 (IK Tau), and [MgS/H2] < 4.5 × 10−10 (R Dor) and <6 × 10−11 (IK Tau). The retrieved upper-limit abundances for these latter molecules are in accord with the chemical model predictions.
Possible Photometric Signatures of Moderately Advanced Civilizations: The Clarke Exobelt
Authors: Socas-Navarro Hector
Published: March 2018

This paper puts forward a possible new indicator of the presence of moderately advanced civilizations on transiting exoplanets. The idea is to examine the region of space around a planet where potential geostationary or geosynchronous satellites would orbit (hereafter, the Clarke exobelt). Civilizations with a high density of devices and/or space junk in that region, but otherwise similar to ours in terms of space technology (our working definition of “moderately advanced”), may leave a noticeable imprint on the light curve of the parent star. The main contribution to such a signature comes from the exobelt edge, where its opacity is maximum due to geometrical projection. Numerical simulations have been conducted for a variety of possible scenarios. In some cases, a Clarke exobelt with a fractional face-on opacity of ∼10−4 would be easily observable with existing instrumentation. Simulations of Clarke exobelts and natural rings are used to quantify how they can be distinguished by their light curves.