bluuebunny/crossref_metadata_2025 huggingface dataset:
Rural Australian Doctors’ Views About Midwifery and Midwifery Models of Care: A Qualitative Study
Authors: McCaffery Siubhan , Small Kirsten , Gamble Jenny
Published: March 2022

BACKGROUND AND PURPOSE

Australian rural areas access to midwifery continuity of carer models is restricted. Lack of medical support has been identified as one of the reasons midwifery continuity of carer models have not been implemented. The purpose of his study was to explore rural Australian doctors’ views about midwifery and midwifery continuity of carer models.

STUDY DESIGN

A qualitative study with general practitioner and specialist obstetricians (n = 10) working in Australian rural maternity services. Semi-structured interviews were undertaken and analyzed using thematic analysis.

FINDINGS

Participants’ views of midwifery and midwifery continuity of carer models were expressed in three themes. The themes related to the concepts of knowing: knowing the model, knowing the midwife, and knowing the system. Participants had misconceptions and misunderstandings of the model, midwifery, and systems issues relating to midwifery continuity of carer models.

CONCLUSION

Increasing understanding about midwifery and midwifery continuity of carer models may facilitate implementation of these models. A national education program for doctors about the structure and function of midwifery continuity of carer models would support knowledge building for obstetric doctors. Strong leadership and incentivization for health services may be needed to sustainably roll-out rural models. At a service level, responsibility for establishing and sustaining models should shift from local midwife leaders to hospital executives.
Validation of the Serbian Adaptation of the Self-Absorption Scale
Authors: Kostić Senka M. , Stanojević Dragana
Published: March 2022

McKenzie and Hoyle made the first Self-Absorption Scale. Since this scale is not available in Serbian, we designed two studies aimed at its adaptation (Study 1, N = 400), and validation of the instrument (Study 2, N = 212). Results of Study 1 confirmed original two-factorial structure, but without two items on each subscale. The reliability of the public self-absorption was α = 0.75; and α = 0.72 for the private self-absorption. The factors in both, the original and adapted version, are congruent (measured by Tucker`s congruence coefficient). Results of Study 2 showed that self-absorption was positively correlated to the most aspects of pathological narcissism, self-consciousness, depression, stress and anxiety. Also, it was negatively correlated to self-esteem. We can conclude that the Self-Absorption Scale is short, reliable, and valid measure for assessing the pathological aspect of self-focusing on Serbian population.
Adölesanlarda diyabete özgü yeme bozukluğu:‘Diabulimia’ riskinin ve metabolik etkilerinin araştırılması
Authors: TURAN Hande , GÜNEŞ KAYA Didem , TARÇIN Gürkan , EVLİYAOĞLU Saadet Olcay , ERCAN Oya
Published: March 2022

Amaç: Tip 1 diabetes mellitus, insülin eksikliği ve hiperglisemi ile karakterize kronik bir hastalıktır. İyi bir glisemik kontrolün için yaşam boyunca günde ortalama en az sekiz defa kan şekeri ölçümü, sağlıklı besinlerin seçimi, porsiyon kontrolü ve düzenli egzersiz gerekmektedir ve tüm bunlar diyabetli bireylerin birçoğunda kaygıya neden olmakta ve yeme bozuklukları riskini arttırmaktadır. Diabulimia, diyabetli bireylerde, vücut ağırlığında kayıp sağlama amacıyla, kasıtlı olarak insülin dozunu azaltmak ve/veya atlamayı ifade eder. Bu çalışmanın amacı diyabete özgü yeme bozukluğu olan diabulimia açısından riskli adölesanların sıklığını araştırmak, yeme bozukluğu gelişmesi riski ile metabolik kontrol ve vücut kitle indeksi arasındaki ilişkisini değerlendirmektir. Gereç ve Yöntem: Çalışmaya Tip 1 diabetes mellitus tanısıyla izlenen 10-18 yaş arası 129 olgu dahil edildi. Katılımcılara DEPS-R (Diabetes Eating Problem Survey, Diyabette Yeme Sorunları Anketi) yüz yüze uygulandı. Demografik, antropometrik parametrelere ilişkin veriler ve HbA1c değerleri hastaların tıbbi dosyalarından elde edildi. Bulgular: Katılımcıların DEPS-R puanları incelendiğinde riskli olguların %53,2‟si (n=25) kız, %46,8‟i (n=22) erkek, toplamda 47 olguda (%36,4) bozulmuş yeme davranışı riski saptandı. Olgular DEPS-R puanına göre yeme davranışı bozukluğu açısından risksiz ve riskli iki gruba ayrılarak incelendiğinde HbA1c ve vücut kitle indeksi riskli grupta anlamlı olarak yüksek saptandı. DEPS-R skoru ile diyabet yaşı, vücut kitle indeksi ve HbA1c değeri arasında zayıf korelasyon saptandı. Sonuç: Riskli diyabetli bireylerde diabulimia gelişmesini önlemek ve hali hazırda yeme bozukluğu geliştirmiş çocukların saptanmasında rutin tarama önem kazanmaktadır. Bu konu ile ilgili daha fazla çalışmaya ihtiyaç olmakla beraber özellikle açıklanamayan kilo kaybı ve kötü metabolik kontrolde diabulimia olasılığı akılda tutulmalıdır ve etkili tedavi için klinisyenlerin farkındalığı arttırmalıdır.
Ege tıp öğretim elemanlarının sürekli mesleki gelişim konusundaki eğitim gereksinimlerinin belirlenmesi
Authors: ŞAHİN Hatice , SEZER Hale , DÖKÜMCÜ Ülküm Zafer , GİRGİN SAĞIN Ferhan , YILDIRIM SÖZMEN Eser , SERTÖZ Şaziye Rüçhan , ÜLKER GÖKSEL Sibel
Published: March 2022

Amaç: Ege Üniversitesi Tıp Fakültesinde görevli olan öğretim elemanlarının sürekli mesleki gelişimini (SMG) sağlayacak eğitici gelişim programlarının planlanması için eğitim gereksinimlerinin belirlenmesi amacıyla gerçekleştirilmiştir. Gereç ve Yöntem: Aralık 2019-Şubat 2020 ayları arasında yapılan kesitsel tipte araştırmadır. Ege Üniversitesi Tıp Fakültesinde görevli olan 225 öğretim elemanına ulaşılmıştır. Araştırmanın verilerini öğretim elemanlarının eğitim gereksinimlerini belirlemeye yönelik hazırlanan dijital anket formu ile toplanmıştır. Veriler, SPSS 21 paket programında değerlendirilmiştir. Verilerin analizinde dağılım istatistikleri (frekans, yüzde, ortalama, standart sapma) kullanılmıştır. Bulgular: Öğretim elemanlarının %61,6‟sı (n:98) Dâhili Bilimler, %17‟si (n:27) Cerrahi Bilimler, %21,4‟ü (n: 34) Temel Bilimlerde görev yapmaktadır. Öğretim elemanları SMG etkinliklerini ayda dört saat, belli zamanlarda tekrarlanan modüler program ve en az 2-5 öğretim yöntemi ile yürütülmesini istedikleri belirlenmiştir. Sürekli mesleki gelişim etkinliklerinde eğitim becerileri olarak asistanların ve Dr. Öğr. Üyelerinin eğitim becerileri konusunda ihtiyaçları olduğu saptanmıştır. Araştırma becerileri olarak asistan ve uzmanların yayın hazırlama ve bilimsel toplantı, diğer öğretim elemanlarının araştırma planlama konusunda gereksinimlerinin olduğu belirlenmiştir. Kişisel gelişim ve uygulama becerileri olarak asistan ve uzmanların bilimsel toplantı, diğer öğretim elemanlarının ise kişisel gelişimlerini destekleyecek eğitimlere ihtiyaçlarının olduğu belirlenmiştir. Sonuç: Eğitici gelişim programlarının planlanmasında eğiticilerin gereksinimlerinin ve isteklerinin belirlenmesi sürekli mesleki gelişim etkinliklerinin başarısını etkilemektedir. Saptanan eğitim gereksinimleri doğrultusunda sürekli mesleki gelişim etkinlikleri düzenlenmesi önerilmektedir.
O ensino superior no contexto pos-comunista
Authors: Nascimento Carolina Monteiro de Castro , Oliveira Amurabi
Published: March 2022

Os estudos sobre ensino superior têm se ampliado no Brasil nas últimas décadas, o que tem ocorrido de forma concomitante à crescente internacionalização do debate. Apesar desses avanços, percebe-se que ainda há pouca literatura disponível em língua portuguesa sobre o ensino superior de certas latitudes como, por exemplo, de países que integraram o bloco comunista e suas transformações após o fim da União das Repúblicas Socialistas Soviéticas (URSS). Neste artigo analisamos o caso da República Tcheca, apresentando as transformações vivenciadas no contexto do pós-comunismo e de sua entrada na União Europeia. Partindo do exemplo tcheco, buscamos destacar como as experiências sócio-históricas moldam a dinâmica do ensino superior, visibilizando as assimetrias da “comunidade global” e enfatizando, ao mesmo tempo, como o investimento em políticas educacionais nesse campo também é capaz de dinamizar essa realidade.
Internacionalização da educação superior na perspectiva sul-sul
Authors: Corte Marilene Gabriel Dalla , Morosini Marilia Costa , Felicetti Vera Lucia
Published: March 2022

Prioriza-se analisar movimentos e contextos emergentes relacionados à internacionalização da Educação Superior na perspectiva sul-sul em tempos pandêmicos, com atenção a internacionalização em casa (IaH) e aos estudantes. A metodologia de pesquisa, natureza qualitativa, constitui-se exploratória-interpretativa com aplicação de questionários on-line à coordenadores de Programas de Pós-graduação (PPGs) da região Sul do Brasil. A análise aborda a articulação de Programas de Pós-graduação quanto a IaH e movimentos de internacionalização sul-sul realizados a partir da pandemia Covid-19. Também, busca-se mapear quais [re]articulações das relações internacionais e de cooperação acadêmica que estão sendo realizadas entre países e Instituições de Educação Superior do global Sul. Tais [re]articulações podem se constituir a partir de movimentos de internacionalização solidária e horizontal ou mercantilista, considerando possíveis novos contextos emergentes na Educação Superior.
ANALISIS EKONOMI WILAYAH DAN EVALUASI DAMPAK PEMBANGUNAN EKONOMI DI KABUPATEN BONDOWOSO
Authors: Azizah Nor Aufa , Kumalawati Rosalina , Normelani Ellyn , Bachri Ahmad Alim
Published: March 2022

Negara berkembang dapat mewujudkan kondisi yang lebih baik dari sebelumnya dengan melakukan pembangunan. Pembangunan yang sering dilakukan oleh negara berkembang adalah pembangunan ekonomi. Pembangunan ekonomi adalah proses peningkatan pendapatan total, yaitu terjadinya peristiwa pertumbuhan ekonomi di suatu negara dengan meningkatkan jumlah penduduk, perubahan mendasar dalam komposisi ekonomi dan distribusi pendapatan. Pembangunan ekonomi merupakan salah satu petunjuk kemajuan keuangan yang harus dilihat melalui peningkatan pembayaran teritorial asli selama periode waktu tertentu.Produk Domestik Regional Bruto (PDRB) merupakan penanda yang signifikan untuk menentukan kondisi keuangan di ruang angkasa dalam jangka waktu tertentu, baik berdasarkan biaya saat ini maupun berdasarkan biaya tetap. sebagian besar tingkat pembangunan ekonomi di Kabupaten Bondowoso relatif meningkat meskipun memiliki pendapatan per kapita yang moderat. Sektor industri yang juga merupakan penyumbang pendapatan terbesar di Kabupaten Bondowoso perlu dikembangkan dan dikelola kembali agar dapat memenuhi target pembangunan dan ekonomi.
ANALISIS KESIAPSIAGAAN BENCANA BANJIR DI SDN PETUKANGAN SELATAN 02 JAKARTA SELATAN
Authors: Qurrotaini Lativa , Diana Diana
Published: March 2022

Penelitian ini dilatarbelakangi dari hasil observasi di SDN Petukangan Selatan 02 Jakarta Selatan belumlah lengkap kesiapsiagaannya. Tujuan dari penelitian ini untuk menganalisis kesiapsiagaan bencana banjir di SDN Petukangan Selatan 02 melalui observasi, wawancara, dan dokumentasi. Penelitian ini dilaksanakan di SDN petukangan Selatan 02 dengan subjek penelitian guru berjumlah 4 orang, petugas kebersihan orang, dan siswa 8 siswa. Jenis penelitian yang digunakan adalah Fenomenologi dengan metode Kulalitatif Deskriptif. Teknik-teknik pengumpulan data yang digunakan ada 3 tahap yaitu Obervasi,Wawancara, dan Dokumentasi. Berdasarkan hasil wawancara dengan guru,staff dan siswa menunjukkan hasil bahwa kesiapsiagaan bencana banjir Sekolah Dasar Negeri Petukangan Selatan 02 Jakarta Selatan belum terlaksana dengan baik, dapat dilihat dari belum adanya penyuluhan tentang kesiapsiagaan banjir. Hasil penelitian diharapkan dapat mengadakan penyuluhan tentang kesiapsiagaan banjir kepada lingkungan masyarakat disekolah guna meningkatkan pengetahuan teroritis tentang bencara banjir dan lebih meningkatkan lagi sarana dan prasarana yang dibutuhkan untuk kesiapsiagaan bencana banjir.
IMPLEMENTASI SEKOLAH SIAGA KEPENDUDUKAN MELALUI PEMBELAJARAN GEOGRAFI DI MAN INSAN CENDEKIA TANAH LAUT
Authors: Ulfah Restu
Published: March 2022

Tujuan penelitian ini untuk mendeskripsikan implementasi pendidikan kependudukan, faktor penghambat implementasi pendidikan kependudukan, dan  upaya yang dilakukan dalam mengimplentasikan pendidikan kependudukan melalui pembelajaran geografi dalam mendukung Sekolah Siaga Kependudukan (SSK) di MAN Insan Cendekia Tanah Laut. Penelitian ini merupakan penelitian penelitian kualitatif dengan pendekatan studi kasus. Teknik analisis data dalam penelitian ini adalah analisis kualitatif yaitu tahapan data reduction, data display, dan conclusion drawing/veryficatiion. Hasil penelitian implementasi pendidikan kependudukan dalam mata pelajaran geografi di kelas XI MAN Insan Cendekia Tanah Laut telah dilaksanakan oleh guru pada perencanaan pembelajaran, proses pembelajaran dan penilaian. Pada rencana pelaksanaan pembelajaran (RPP) implementasi pendidikan kependudukan dapat dilihat pada kompetensi dasar, indikator dan tujuan pembelajaran. Faktor penghambat implementasi pendidikan kependudukan adalah siswa beranggapan materi kependudukan terlalu luas dan banyak hapalan serta motivasi belajar siswa yang kurang. Upaya yang dilakukan oleh guru geografi dalam mengimplementasikan pendidikan kependudukan adalah memberikan metode dan media pembelajaran yang menarik untuk mempelajari materi kependudukan serta penyediaan layanan pojok kependudukan
Non-Hemostatic Functions of Human Blood Platelets: Effects of Bioactive Compounds
Authors: Das Diptimayee , Adhikary Subhamay , Banerjee Antara , Radhakrishnan Arun Kumar , Pathak Surajit , Duttaroy Asim K.
Published: March 2022

Platelets have long been associated with sustaining the balance between hemostasis and thrombosis. Platelets, however, are also involved in a wide range of biological activities, including inflammation, immunology, wound healing, cancer biology, and angiogenesis. Platelets' diverse roles are mediated by the expression of various adhesive and immune receptors and the secretion of a diverse array of bioactive proteins, ions stored in granules, and several lipid mediators. Platelets also release pro-inflammatory and anti-inflammatory, and angiogenic factors and shed microparticles into the bloodstream. The challenge for therapeutic intervention in non-hemostatic disease is identifying the factors that primarily inhibit specific targets implicated in platelets' complicated contribution to inflammation or tumor growth while leaving their hemostatic function intact. In addition, blood platelets are involved in infection and innate and adaptive immunity by mediating complicated vascular homeostasis via specialized receptors and granule release, RNA transfer, and mitochondrial secretion. Anti-platelet drugs/bioactive compounds are developed based on their platelet anti-aggregatory properties; however, very little information is available on their effects on non-hemostatic function. Therefore, a better understanding of the impact of the anti-platelet bioactive on the platelets' diverse roles and mechanisms may help develop new strategies and prevent CVD and other diseases. In this review, a comprehensive overview of platelet multifunctional roles in CVD and other diseases and dietary factors' modulatory effects are described.
Convolutional LSTM Approach for Left Ventricle Segmentation and Estimation of Left Ventricle Ejection Fraction in Echocardiography
Authors: Jeong Jin Gyo , Kim DongHyun , Kim Young Jae , Yoo Kyungmin , Ha Kyungeun , Chung Wook-Jin , Kim Kwang Gi
Published: March 2022

Cardiovascular disease is the leading cause of death worldwide. A key factor in assessing the risk of cardiovascular disease is left ventricular functional evaluation. Left ventricular (LV) systolic function is evaluated by measuring the left ventricular ejection fraction (LVEF) using echocardiography data. Therefore, quick and accurate left ventricle segmentation is important for estimating the LVEF. However, it is difficult to accurately segment the left ventricle due to changes in the shape and area of the left ventricle during cardiac cycles. In this study, we proposed a framework that considers changes in the shape and area of the left ventricle during the cardiac cycle by applying the convolutional long short-term memory (CLSTM) approach. In addition, we evaluated the left ventricular segmentation and multidimensional quantification of the proposed system in comparison to manual and automated segmentation methods. In addition, to assess the validity of CLSTM, the values of multi-dimensional quantification metrics were compared and analyzed using graphs and Bland–Altman plots on a frame-by-frame basis. We demonstrated that the CLSTM method effectively segments the left ventricle by considering the LV activity. In conclusion, we demonstrated that LV segmentation based on our framework may be utilized to accurately estimate LVEF values.
Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency
Authors: Barreto Sara , Al-Zubaidi Mohammed A , Dale Tina P , Worrall Amy J , Kapacee Zoher , Kimber Susan J , Sulé-Suso Josep , Forsyth Nicholas R , Rutter Abigail V
Published: March 2022

Human pluripotent stem cells (hPSCs) have widespread potential biomedical applications. There is a need for large-scale in vitro production of hPSCs, and optimal culture methods are vital in achieving this. Physiological oxygen (2% O2) improves key hPSCs attributes, including genomic integrity, viability, and clonogenicity, however, its impact on hPSC metabolism remains un-clear. Here, Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) was used to detect and quantify metabolic Volatile Organic Compounds (VOCs) in the headspace of hPSCs and their differentiated progeny. hPSCs were cultured in either 2% O2 or 21% O2. Media was collected from cell cultures and transferred into glass bottles for SIFT-MS measurement. The VOCs acetaldehyde and dimethyl sulfide (DMS)/ethanethiol were significantly increased in undifferentiated hPSCs compared to their differentiating counterparts, and these observations were more apparent in 2% O2. Pluripotent marker expression was consistent across both O2 concentrations tested. Transcript levels of ADH4, ADH5, and CYP2E1, encoding enzymes involved in converting ethanol to acetaldehyde, were upregulated in 2% O2, and chemical inhibition of ADH and CYP2E1 decreased acetaldehyde levels in hPSCs. Acetaldehyde and DMS/ethanethiol may be indicators of altered metabolism pathways in physiological oxygen culture conditions. The identification of non-destructive biomarkers for hPSC characterization has the potential to facilitate large-scale in vitro manufacture for future biomedical application.
Radiation spectra in ionizing gas flows for the QSPA-T installation with a longitudinal field
Authors: Klimov Nikolai Sergeyevich , Gutorov Konstantin Mikhailovich , Kovalenko Dmitry Vladimirovich , Kozlov Andrey Nikolaevich , Konovalov Venyamin Sergeevich , Podkovyrov Vyacheslav Leonidovich , Yaroshevskaya Anna Dmitrievna
Published: March 2022

The results of calculations of the spectral and integral characteristics of radiation in flows of ionizing gases in the channel of the quasi-stationary plasma accelerator in the presence of an additional longitudinal magnetic field are presented. The numerical model of the radiative magnetogasdynamics is based on the modified transport equations for the multicomponent medium consisting of atoms, ions, and electrons. The MHD equations for two-dimensional axisymmetric flows are presented in terms of the azimuthal components of magnetic field and vector potential of magnetic field, taking into account the electrical conductivity, thermal conductivity, and radiation transport. The spectral and integral characteristics of radiation were determined within the framework of the 3D model using the method of long characteristics in the multigroup approximation.
Pengaruh Musik Gamelan terhadap Atensi pada Mahasiswa Kedokteran FK UNS (Kajian Neuroplastisitas)
Authors: Kresnantyo Adi Nugroho  , Nanang Wioyono  , Yunia Hastami  , Siti Munawaroh
Published: March 2022

Pendahuluan: Neuroplastisitas merupakan kemampuan jaringan saraf untuk membentuk sinaps baru atau mengganti yang rusak dan dipengaruhi oleh lingkungan. Konsep tersebut telah diadaptasikan untuk terapi gangguan neurologik. Penelitian ini mencoba untuk mengkaji konsep neuroplastisitas terhadap atensi pada mahasiswa kedokteran karena memiliki urgensi tersendiri yaitu untuk meningkatkan kemampuan atensi guna menunjang kegiatan yang memerlukan fungsi kognitif. Intervensi yang diberikan adalah aktivitas mendengarkan musik gamelan. Sampai saat ini belum ada penelitian tentang kajian neuroplastisitas pengaruh musik gamelan terhadap fungsi atensi. Penelitian ini bertujuan untuk mengetahui pengaruh mendengarkan musik gamelan terhadap atensi.

Metode: Penelitian ini termasuk penelitian eksperimental dengan pretest posttest control group design. Jumlah responden yang diteliti sebanyak 27 mahasiswa dibagi menjadi 3 kelompok yaitu A (kontrol), B1 (15 menit) dan B2 (30 menit). Pemberian intervensi berupa aktivitas mendengarkan musik gamelan pada kelompok eksperimen selama 14 hari. Data yang didapatkan dianalisis menggunakan uji T berpasangan dan uji One Way Anova.

Hasil: Hasil skor posttest pada semua komponen atensi kelompok eksperimen mengalami perbaikan. Hasil uji T berpasangan tidak terdapat perbedaan yang signifikan pada seluruh komponen atensi dengan nilai p kelompok A, B1 dan B2 berturut-turut yaitu alerting (0,781; 0,056; 0,606), Orienting (0,395; 0,340; 0,272), dan Executive Control (0,240; 0,653; 0,068). Hasil uji One Way Anova post-intervensi tidak terdapat perbedaan yang signifikan antara kelompok perlakuan dengan nilai p yaitu Alerting (0,433), Orienting (0,948) dan Executive Control (0,416).

Kesimpulan: Tidak ada pengaruh mendengarkan musik gamelan terhadap fungsi atensi pada mahasiswa kedokteran. Namun demikian, terdapat perbaikan rerata skor seluruh fungsi atensi.
Hubungan Antara Tingkat Aktivitas Fisik Dengan Derajat Nyeri Pada Pasien Osteoarthritis Lutut di RS UNS
Authors: Devita Intania Putri Gunadi  , Kurniawati Tandiyo Desy , Hastami Yunia
Published: March 2022

Pendahuluan: Osteoarthritis lutut adalah penyakit sendi degeneratif yang menyerang tulang rawan sendi. Sebanyak 80% penderitanya memiliki keterbatasan dalam beraktivitas dan 25% diantaranya tidak bisa melakukan aktivitas sehari-hari. Penelitian ini bertujuan untuk menganalisis hubungan antara tingkat aktivitas fisik dengan derajat nyeri pada pasien osteoarthritis lutut.

Metode: Penelitian ini menggunakan metode observasional analitik dengan pendekatan cross sectional. Subjek penelitian adalah pasien osteoarthritis lutut Instalasi Rehabilitasi Medik RS UNS. Terdapat 25 subjek yang memenuhi kriteria, terbagi menjadi 9 laki-laki dan 16 perempuan. Variabel bebas penelitian adalah tingkat aktivitas fisik yang diukur menggunakan kuesioner International Physical Activity Questionnaire (IPAQ). Variabel terikat penelitian adalah derajat nyeri, diukur menggunakan Numerical Rating Scale(NRS). Hubungan antar variabel diuji menggunakan uji Spearman.

Hasil: Terdapat hubungan yang signifikan antara tingkat aktivitas fisik dengan derajat nyeri saat ini (p=0,015) dan korelasi negatif dengan kekuatan korelasi sedang (r=-0,479). Tidak terdapat hubungan yang signifikan antara tingkat aktivitas fisik dengan derajat nyeri dahulu (p>0,05).

Kesimpulan: Tingkat aktivitas fisik memiliki hubungan yang berkorelasi negatif dengan derajat nyeri saat ini, sedangkan tingkat aktivitas fisik tidak memiliki hubungan dengan derajat nyeri dahulu pada pasien osteoarthritis lutut di RS UNS.

Kata Kunci: Aktivitas Fisik; Derajat Nyeri; Osteoarthritis Lutut
Fracturing Optimization Design of Fractured Volcanic Rock in Songliao Basin Based on Numerical Research and Orthogonal Test
Authors: Liu Zhaoyi , Pan Zhejun , Li Shibin , Zhang Ligang , Wang Fengshan , Wang Changhao , Han Lingling , Ma Yuanyuan , Li Hao , Wang Peng , Huang Yize
Published: March 2022

The efficient development of fractured volcanic reservoir relies on fracturing, while the existence of natural fractures has an important impact on hydraulic fracturing in this reservoir. There are few reports on fracturing optimization of deep volcanic gas reservoirs in Songliao Basin in China; thus, the parameter optimization under single-stage action is studied. On the basis of logging interpretation, coring observation, and seismic interpretation, the fracture development degree is obtained. By employing numerical simulation and orthogonal tests, hydraulic fracturing optimization design is carried out. The results indicate that the pumping rate of 0.01 m3/s/m and perforation direction parallel to the maximum principal stress are the optimum parameters for the studied volcanic reservoirs. In addition, multibranch seam expansion will occur when the displacement reaches 0.01 m3/s/m according to fracture morphology results after fracturing. And the research method has certain significance for improving the fracturing design of fractured reservoir in the research block.
Hydrogen Production and Char Formation Assessment through Supercritival Gasification of Biomass
Authors: Mohamadi-Baghmolaei Mohamad , Zahedizadeh Parviz , Hajizadeh Abdollah , Zendehboudi Sohrab
Published: March 2022

The massive potential in biomass gasification could satisfy the rising energy demand. A promising technology for sustainable hydrogen production is supercritical water gasification of biomass (SCWG). This study proposes a new model to assess gas yields and char formation through SCWG. To this end, a thermodynamic approach is utilized to model the reactor, assuming the equilibrium condition. The impact of catalyst on the SCWG is also involved in the new model, considering a deviation term for the Gibbs free energy of solid char. Two different feedstocks, including sunflower and corncob, are assessed toward SCWG. The newly developed model considerably improves gas yields and char formation predictions considering the experimental data. Compared to the non-modified modeling strategy, the sunflower and corncob's gas yield and char formation are improved by 85.37 and 62.52, respectively. The sensitivity results indicate that temperature and feed concentration substantially impact the gas yields and char formation, while pressure is less impactful.
Texture Analysis of Breast DCE-MRI to Predict Benign and Malignant Tumors and HER-2 Status Using Machine Learning and Deep Learning
Authors: You Jia , Zhang Bin , yin Jiandong
Published: March 2022

Objectives: The purpose of this study was to evaluate the diagnostic performance of three classification models that utilize logistic regression analysis (LRA), support vector machine (SVM), and convolutional neural network (CNN) in distinguishing breast tumor properties and HER-2 status using quantitative analysis of breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods: A total of 354 patients who underwent breast DCE-MRI were included in this retrospective study. All enrolled patients were divided into benign and malignant groups. Patients with breast cancer were divided into positive and negative HER-2 groups. Each group was then divided into training and validation cohorts using different MRI scanners. Machine learning texture analysis was realized using LRA and SVM. Least absolute shrinkage and selection operator (LASSO) were used to filter texture features. Deep learning was implemented using CNN. The classification model performance was evaluated using receiver operating characteristic (ROC) analysis. Results: When distinguishing breast tumor properties, three classifiers based on LASSO_LRA, LASSO_SVM, and CNN in the training cohorts achieved the areas under ROC curves (AUCs) of 0.937, 0.946, and 0.995 (accuracy = 88.75%, 89.37%, and 95.63%), respectively. Three classifiers in the corresponding validation cohorts achieved AUCs of 0.896, 0.914, and 0.965 (accuracy = 83.30%, 85.56%, and 91.11%), respectively. When identifying the HER-2 status, three classifiers in the training cohorts reached AUCs of 0.907, 0.914, and 0.954 (accuracy = 82.61%, 86.09%, and 92.17%), respectively. Three classifiers in the corresponding validation cohorts reached AUCs of 0.819, 0.869, and 0.923 (accuracy = 81.43%, 84.29%, and 87.14%), respectively.Conclusion: The performance of the deep learning approach with CNN is superior to that of machine learning approaches employing LRA and SVM. These results suggest that the classifier based on CNN can be used as an efficient tool for preoperative evaluation of breast tumor properties and HER-2 status.
miRNA-518a-3p inhibits hepatocarcinogenesis by suppressing ZNF281
Authors: Chen Diandian , Shi Kezhi , Hu Yili
Published: March 2022

Background: Emerging evidences have indicated that microRNAs (miRNAs) play a significant role in multiple biological processes, including the control of the cell cycle, apoptosis, autophagy and metabolic reprogramming. Among them, miRNA-518a-3p has been revealed to display a notably key function during the development of many types of cancer, containing colorectal cancer, breast cancer and squamous cell carcinoma. However, its functions and the molecular mechanisms during HCC progression still remain unclear. Methods: miRNA-518a-3p expression level was detected by RT-qPCR in HCC tumor tissues and four HCC cell lines, and its related prognostic effects were also investigated. Furthermore, its functions during HCC progression were investigated by CCK-8 experiment, transwell assay in two HCC cell lines. Moreover, its potential mechanisms were investigated by bioinformatic analysis, RT-qPCR, western blotting, luciferase reporter assay and rescue experiments. Results: Downregulation of miRNA-518a-3p was found in HCC tumor tissues and correlated with a more awful overall survival. Gain and loss of function analyses displayed miRNA-518a-3p repressed HCC cells proliferation, migration and invasion. Then, bioinformatic analysis and luciferase reporter assay have suggested that ZNF281, upregulated in HCC tumor tissues, was negatively regulated by miRNA-518a-3p. Moreover, rescue experiments demonstrated that the suppression of HCC progression by miRNA-518a-3p was mediated by ZNF281.Conclusion: Our studies indicated that miRNA-518a-3p inhibited hepatocarcinogenesis through suppression of ZNF281 expression, indicating that miRNA-518a-3p is a promising therapeutic approach targeting for the treatment of HCC.
Effect of body mass index on postoperative mechanical alignment and long-term outcomes of residual varus after total knee arthroplasty: a retrospective cohort study of 671 knees
Authors: Lai Ya-hao , Su Qiang , Li Ze-xi , Feng Wei , Cao Jian , Xu Hong , Zhou Zongke
Published: March 2022

Background
High body mass index (BMI) is associated with increased rates of complications after total knee arthroplasty (TKA). Here, we aimed to investigate the potential association between high BMI and incidence of postoperative misalignment in patients undergoing TKA for varus osteoarthritis. We also evaluated whether higher BMI is associated with shorter prosthetic survival and worse clinical function in patients with postoperative residual varus.
Methods
We retrospectively reviewed 671 patients who underwent primary TKA for varus osteoarthritis between January 2010 and December 2015. The mean follow up was 8.16 years (± 1.45 years). Patients were divided into five groups depending on their BMI: normal weight (< 25.0 kg/m2), overweight (25.0–29.9 kg/m2), class I obese (30.0–34.9 kg/m2), class II obese (35–39.9 kg/m2), and class III obese (> 40 kg/m2). All patients underwent standing, full-length radiography before and after surgery in order to measure the mechanical hip-knee-ankle axis angle (HKA). After excluding 496 non-varus knees, we followed up 175 residual varus knees. Among the BMI subgroups, we compared prosthetic survival and knee function scores, including Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, Knee Society Knee Score (KS-KS), Knee Society Function Score (KS-FS), Forgotten Joint Score (FJS), and range of motion (ROM).
Results
Multivariate and logistic regression revealed that preoperative alignment and higher BMI were associated with higher risk of postoperative misalignment. ROM and KS-FS were similar among all groups. WOMAC was higher in the normal and overweight groups than in the other groups. FJS and KS-KS gradually decreased with increasing BMI. Kaplan-Meier survival analysis showed a non-significant trend towards lower prosthetic survival with higher BMI.
Conclusions
Higher BMI is associated with greater risk of misalignment after TKA. Among patients with postoperative residual varus, those with class II and III obesity had worse long-term clinical outcomes. However, long-term prosthetic survival was similar between among the BMI subgroups.
Trial registration:
The trial was registered in the Chinese Clinical Trial Registry (ChiCTR2000038360).
Evaluation of Abdominal Compression-Decompression Combined With Chest Compression CPR Performed by a New Device: Is the Prognosis Improved After This Combination CPR Technique?
Authors: Li Haishan , Wang Chao , Zhang Hongyuan , Cheng Fang , Zuo Shuang , Xu Liyou , Chen Hui , Wang Xiaodong
Published: March 2022

Introduction: This study was designed to compare outcomes between standard cardiopulmonary resuscitation (STD-CPR) and combined chest compression and abdominal compression-decompression cardiopulmonary resuscitation (CO-CPR) with a new device following out-of-hospital cardiac arrest. Moreover, we investigated whether patient prognosis improved with this combination treatment.Methods: This trial was a single-center, prospective, randomized trial with a blinded assessment of the outcome. A total of 297 consecutive patients with OHCA were initially screened, and 278 were randomized to STD-CPR (n=135) or CO-CPR (n=143). We compared return of spontaneous circulation (ROSC) rates, survival to hospital admission rates, survival to hospital discharge rates, and neurological outcomes at hospital discharge between the two groups. In addition, we also performed the Kaplan-Meier analysis at the end of the follow-up. Results: An ROSC rate of 31/135 (22.96%) versus 35/143 (24.48%), and survival to a hospital admission rate of 28/135 (20.74%) versus 33/143 (23.07%) were found between in the CO-CPR group and the STD-CPR group respectively. The difference did not reach statistical significance. However, there was a significant difference in the survival to hospital discharge rates of 16/135 (11.85%) versus 7/143 (4.90%) between the two groups. 9 patients (6.67%) in the CO-CPR group versus 2 patients (1.40%) in the STD group with good neurological outcomes were obtained according to the CPC status, and the difference was statistically significant( P=0.003). And the Kaplan-Meier analysis showed a survival benefit favoring the CO-CPR group over the STD-CPR group at the end of the follow-up (P=0.007).Conclusion: Patients who had suffered out-of-hospital cardiac arrest could achieve better survival benefits from CO-CPR than from STD-CPR.
Effects of Husband Involvement in Prenatal Care on Couples’ Intimacy and Postpartum Blues in Primiparous Women
Authors: Dehshiri Maryam , Ghorashi Zohreh , Lotfipur S. Maryam
Published: March 2022

Background: Husband involvement in prenatal care is a relatively new concept in developing countries, including Iran. Considering the key role of men in the promotion of women's health, this study aimed to determine the effects of husband involvement in prenatal care on couples' intimacy and postpartum blues in primiparous pregnant women referring to selected comprehensive health centers in Rafsanjan in 2021.Methods: This experimental study was performed on 69 primiparous pregnant women aged 15-45 years with a gestational age of 20-36 weeks. Participants in the intervention group were accompanied by their husbands and received routine prenatal care and virtual training. Participants in the control group received routine prenatal care without husband involvement. The Unidimensional Relationship Closeness Scale (URCS) was completed in two stages, before intervention and two weeks after delivery, and the Stein questionnaire was completed one week after delivery. Data was analyzed with T-test, Chi-square and Fisher exact tests.Results: The results showed that the incidence of postpartum blues was significantly lower in the intervention group than in the control group (p <0.001). The mean score of couples' intimacy after intervention increased in the intervention group and decreased in the control group; however, the difference was not statistically significant (p = 0.08).Conclusion: Husband involvement in prenatal care and virtual training for couples may be effective in controlling postpartum blues and possibly in increasing couples' intimacy.
ATPase activity of DFCP1 controls selective autophagy
Authors: Nähse Viola , Raiborg Camilla , Tan Kia Wee , Mørk Sissel , Torgersen Maria , Wenzel Eva , Nager Mireia , Salo Veijo , Johansen Terje , Ikonen Elina , Schink Kay , Stenmark Harald
Published: March 2022

Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER) known as omegasomes, which are characterized by the presence of the ER protein DFCP1/ZFYVE1. The function of DFCP1 is unknown, as are the mechanisms of omegasome formation and constriction. Here, we demonstrate that DFCP1 is an ATPase that dimerizes in an ATP-dependent fashion. Whereas depletion of DFCP1 had a minor effect on bulk autophagic flux, DFCP1 was required to maintain the autophagic flux of p62 under both fed and starved conditions, and this was dependent on its ability to bind and hydrolyse ATP. While DFCP1 mutants defective in ATP binding or hydrolysis localized to forming omegasomes, these omegasomes failed to constrict. Consequently, the release of nascent autophagosomes from omegasomes was markedly delayed. DFCP1 was found to associate with ubiquitinated proteins, and degradation of ubiquitinated cargoes such as protein aggregates, mitochondria and micronuclei was strongly inhibited when DFCP1 was knocked out or mutated. Thus, DFCP1 mediates ATPase-driven constriction of omegasomes to release autophagosomes for selective autophagy.
Current availability and distribution of Congo basin's freshwater resources
Authors: Tourian Mohammad J. , Papa Fabrice , Elmi Omid , Sneeuw Nico , Kitambo Benjamin , Tshimanga Raphael , Paris Adrien , Calmant Stephane
Published: March 2022

The Congo Basin is of global significance for biodiversity and the water and carbon cycles. However, its freshwater availability remains highly unknown. Here, we leverage a new method to characterize the relationship between drainable water storage and river discharge across the entire basin. We estimate that the Congo Basin currently holds 481±24 km³ of Total Drainable Water Storage, unevenly distributed throughout the region, with 68% being stored in the southernmost sub-basins, Kasaï (227±17 km³) and Lualaba (146±7 km³), while the northern sub-basins contribute only 173±8 km³. We further estimate the time constant for draining its entire water storage to be 4.3±0.4 month, but, regionally, large lakes act as resistors resulting in greater time constants of up to 105±3 month. Our estimate provides a robust basis to address the challenges of water demand for 120 million inhabitants, a population expected to double in a few decades.
Spontaneous generation and active manipulation of real-space optical vortex
Authors: Seo Min-Kyo , Kim Dongha , Baucour Arthur , Choi Yun-Seok , Shin Jonghwa
Published: March 2022

Optical vortices host the orbital nature of photons1, which offers an extra degree of freedom in photonic applications2,3,4,5,6,7,8. Unlike vortices in other physical entities, optical vortices require structural singularities9,10,11,12, which restrict their abilities in terms of dynamic and interactive characteristics13,14,15,16,17. In this study, we present the spontaneous generation and external magnetic field-induced manipulation of an optical vortex and antivortex. A gradient-thickness optical cavity (GTOC) consisting of an Al/SiO2/Ni/SiO2 multilayer structure realised the distinct transition between the trivial and non-trivial topological phases, depending on the magneto-optic effects of the Ni layer. In the non-trivial topological phase, the mathematical singularities generating the optical vortex and antivortex pair in the reflected light existed in the generalised parameter space of the thicknesses of the top and bottom SiO2 layers, which is bijective to the real space of the GTOC. Coupled with the magnetisation, the optical vortex and antivortex in the GTOC experienced an effective spin-orbit interaction and showed topology-dependent dynamics under external magnetic fields. We expect that field-induced engineering of optical vortices will pave the way for the study of topological photonic interactions and their applications.
Accuracy of The Axillary Temperature Screening Compared to Core Rectal Temperature.
Authors: Alayed Yazeed , Hommadi Abdullah , Alkhalifah Mohammed , Bashir Muhammad
Published: March 2022

Purpose: To compare the sensitivity of axillary and rectal temperature in infants who presents to the emergency department with a recent history of fever in order to implement an early diagnostic modality to reduce risk of sepsis, urgency in antibiotic administration and decrease the need for delayed hospital admission. Methods: A single-centre cross-sectional comparative study of 201 patients who presents with a recent history of fever. Infants Up to 12 months of age were included. Any patient with the following comorbidities were excluded: (1) Haematological malignancy (2) immunocompromised (3) hyperthyroidism (4) recent administration of antipyretics medications and (5) congenital anal or rectal malformation. Demographic characteristics such as age and gender, weight, mean axillary and rectal temperatures were documented. Fever is defined as rectal temperature > 38 C as opposed to >37.4 in the axillary method. Pearson’s correlation between axillary and rectal temperatures was determined. Results: The mean age was 6.1 ± 3.5 months. The study had 111 (55.2%) males and 90 (44.8%) females. The mean weight was 7.4 Kg ± 2.1 Kg. The mean (SD) rectal-axillary temperature difference was 0.8 °C ± 0.7 °C which was statistically significant (P<0.001). The sensitivity, specificity, positive predictive and negative predictive values of the axillary method for fever > 37.4 were 79.34% (95% CI [73-84.9]), 14.3% (95% CI [0.36-57.9]), 96.2% (95% CI [95-97.2]) and 2.4% (95% CI [0.4-13.5]), respectively. Conclusion: the axillary temperature measurement method is not as accurate as the rectal temperature method for the detection of fever in infants with a recent history of fever. The rectal method remains highly important for accurate and prompt diagnosis.
Fresh-marketable tomato yields enhanced by moderate weed control and suppressed fruit dehiscence with woodchip mulching
Authors: Horimoto Sakae , Fukuda Kazuaki , Yoshimura Jin , Ishida Atsushi
Published: March 2022

The plastics have recently been recognized as serious global environmental hazards, because they do not decay in nature. The use of plastic film for mulching imposes various environmental risks in agroecosystems. The replacement of plastics with organic materials for mulching has been suggested to enhance the sustainability of agroecosystems. However, whether woodchip mulch can be used for annual crops needs to be verified, and it is still rarely used in vegetable fields. We examined the effects of mulberry woodchip mulches on tomato fruit yields over two successive years. Setting three treatments, including woodchip mulch, weed-free and weedy (i.e., unweeded) treatments, we compared the amounts of fresh-marketable and unmarketable tomato fruits. The yields of fresh-marketable tomato fruits in the woodchip mulch treatment were significantly higher than those in the weed-free treatment and comparable to those in the weedy treatment. The yields of unmarketable dehiscent tomato fruits in the weed-free treatment were significantly highest among the treatments. The woodchip mulches moderately suppressed the weed density, while the weeds that did occur grew large, preventing strong sunlight exposure and dehiscence of tomato fruits. The replacement of plastics by woodchips is a possible alternative, facilitating climate change mitigation and adaptation with agroforestry practices.
Effect of Smoking on Endocrine Therapy for Stage IV Hormone Receptor Positive Breast Cancer
Authors: Takada Koji , Kashiwagi Shinichiro , Yabumoto Akimichi , Iimori Nozomi , Goto Wataru , Asano Yuka , Tauchi Yukie , Morisaki Tamami , Ogisawa Kana , Shibutani Masatsune , Ohira Masaichi
Published: March 2022

Background: Smoking worsens breast cancer prognosis. It has been reported that tobacco components directly reach mammary gland tissue, causing smoking-related DNA damage and biological effects. We hypothesized that smoking may have a characteristic course other than the therapeutic effect in patients with stage IV hormone receptor-positive breast cancer (HRBC) who received endocrine therapy as the first-line treatment.Methods: Fifty-six patients diagnosed with stage IV HRBC were treated with endocrine therapy as the first-line treatment. Before treatment, the period and amount of smoking were confirmed through patient interviews, and each pack-year was recorded.Results: It was significantly more frequent for smokers to be evaluated for disease progression due to the appearance of new metastases during endocrine therapy as first-line treatment (p=0.034). Furthermore, as the pack-year increased, new metastases tended to appear (pack-year ≤15; hazard ratio [HR] 1.929, p=0.507; pack-year 15–30, HR 3.857, p=0.223; pack-year >30, HR: 7.714, p=0.028).Conclusions: In stage IV HRBC, smoking increases the metastatic potential of breast cancer, suggesting that changes in its biology may lead to poor prognosis.
Ageing with HIV: Challenges and coping mechanisms of older adults 50 years and above living with HIV in a less developed Country
Authors: Mbalinda Scovia Nalugo , Lusota Derrick Amooti , Martin Muddu , Nyashanu Mathew
Published: March 2022

Introduction: Globally, adults 50 years and older are an increasing proportion of persons living with HIV (PLHIV), accounting for 16% of the patient group globally. The long-term effects of antiretroviral use are still being discovered and have been associated with several comorbidities; Stigma presents challenges for those in need of services and health care and can significantly affect mental health and treatment adherence. Understanding the experiences and challenges of older PLHIV will inform the development of interventions to improve their care, health, and quality of life, which may help prevent the further spread of HIV. We explored the experiences and challenges of older PLHIV ages 50 years and above.Methods: We conducted 40 in-depth interviews with elderly PLHIV aged 50 years and above who had lived with HIV for more than ten years. We also explored experiences and challenges of ageing with HIV in two hospitals. We analysed the data thematically. Results: The key themes that emerged included; late diagnosis of HIV, depression and fear at the time of diagnosis, acceptance of close family, stigma from community, polypharmacy, development of comorbidities, financial burden, resilience, and mastery of own care. Conclusion: Older adults experience several challenges, and there is a need to develop special clinics providing appropriate care for the ageing and their social life. Prevention, Early diagnosis and appropriate treatment of HIV, and appropriate geriatric care are essential for the well-being of elderly PLHIV.