bluuebunny/crossref_metadata_2025 huggingface dataset:
Seismic Vulnerability of Sub-Structures: Vantitelli’s Modulus in Murena Palace
Authors: Gusella Vittorio , Liberotti Riccardo
Published: September 2020

This paper focuses on the Murena Palace in Perugia, part of an architectural complex designed by Luigi Vanvitelli and completed by Carlo Murena in the 18th century. In the context of the seismic vulnerability assessment of this masonry building, the safety of a construction modulus, which gathers several peculiar features identified within the edifice, is analyzed by means of an integrated architectural-structural approach. This construction modulus, that will be called Vanvitelli’s Modulus, is characterized by an intrinsic structural asymmetry with clusters of rooms with masonry vaults, combining different heights, where load bearing walls are standing on top of the vaults. Given these peculiarities, this construction modulus has to be analyzed as a sub-structure with regards to the seismic vulnerability. To this purpose, experimental tests, in particular videoendoscopies and structural monitoring, were conducted to identify geometrical features of walls and vaults, mechanical characteristic of materials and the actual damage condition. From an accurate survey, an innovative parametric approach has been proposed to build the geometrical model of the construction modulus. This has been used, by FEM (finite element method), to perform a structural analysis whose results have been checked by comparison with the actual damage patterns. The proposed integrated architectural-structural approach permits a deeper comprehension of the structural principles that characterize Vanvitelli’s construction modulus and to estimate its seismic vulnerability.
Molecular Classification of Endometrial Stromal Sarcomas Using RNA Sequencing Defines Nosological and Prognostic Subgroups with Different Natural History
Authors: Brahmi Mehdi , Franceschi Tatiana , Treilleux Isabelle , Pissaloux Daniel , Ray-Coquard Isabelle , Dufresne Armelle , Vanacker Helene , Carbonnaux Melodie , Meeus Pierre , Sunyach Marie-Pierre , Bouhamama Amine , Karanian Marie , Meurgey Alexandra , Blay Jean-Yves , Tirode Franck
Published: September 2020

A series of 42 patient tumors diagnosed as endometrial stromal sarcoma (ESS) based on the morphology but negative for JAZF1 and/or YWHAE rearrangement in FISH was analyzed by RNA-sequencing. A chromosomal rearrangement was identified in 31 (74%) of the cases and a missense mutation in known oncogenes/tumor suppressor genes in 11 (26%). Cluster analyses on the expression profiles from this series together with a control cohort composed of five samples of low grade ESS harboring a JAZF1-SUZ12 fusion, one high grade ESS harboring a BCOR-ITD, two uterine tumors resembling ovarian sex cord tumors, two samples each of uterine leiomyoma and leiomyosarcomas and a series of BCOR-rearranged family of tumor (n = 8) indicated that tumors could be gather in three distinct subgroups: one mainly composed of BCOR-rearranged samples that contained seven ESS samples, one mainly composed of JAZF1-fused ESS (n = 15) and the last composed of various molecular subtypes (n = 19). These three subgroups display different gene signatures, different in silico cell cycle scores and very different clinical presentations, natural history and survival (log-rank test, p = 0.004). While YWHAE-NUTM2 fusion genes may be present in both high and low grade ESS, the high-grade presents with additional BCOR or BCORL1 gene mutations. RNAseq brings clinically relevant molecular classification, enabling the reclassification of diseases and the guidance of therapeutic strategy.
Cellular Mechanisms Accounting for the Refractoriness of Colorectal Carcinoma to Pharmacological Treatment
Authors: Marin Jose J.G. , Macias Rocio I.R. , Monte Maria J. , Herraez Elisa , Peleteiro-Vigil Ana , Blas Beatriz Sanchez de , Sanchon-Sanchez Paula , Temprano Alvaro G. , Espinosa-Escudero Ricardo A. , Lozano Elisa , Briz Oscar , Romero Marta R.
Published: September 2020

The unsatisfactory response of colorectal cancer (CRC) to pharmacological treatment contributes to the substantial global health burden caused by this disease. Over the last few decades, CRC has become the cause of more than 800,000 deaths per year. The reason is a combination of two factors: (i) the late cancer detection, which is being partially solved by the implementation of mass screening of adults over age 50, permitting earlier diagnosis and treatment; (ii) the inadequate response of advanced unresectable tumors (i.e., stages III and IV) to pharmacological therapy. The latter is due to the existence of complex mechanisms of chemoresistance (MOCs) that interact and synergize with each other, rendering CRC cells strongly refractory to the available pharmacological regimens based on conventional chemotherapy, such as pyrimidine analogs (5-fluorouracil, capecitabine, trifluridine, and tipiracil), oxaliplatin, and irinotecan, as well as drugs targeted toward tyrosine kinase receptors (regorafenib, aflibercept, bevacizumab, cetuximab, panitumumab, and ramucirumab), and, more recently, immune checkpoint inhibitors (nivolumab, ipilimumab, and pembrolizumab). In the present review, we have inventoried the genes involved in the lack of CRC response to pharmacological treatment, classifying them into seven groups (from MOC-1 to MOC-7) according to functional criteria to identify cancer cell weaknesses. This classification will be useful to pave the way for developing sensitizing tools consisting of (i) new agents to be co-administered with the active drug; (ii) pharmacological approaches, such as drug encapsulation (e.g., into labeled liposomes or exosomes); (iii) gene therapy interventions aimed at restoring the impaired function of some proteins (e.g., uptake transporters and tumor suppressors) or abolishing that of others (such as export pumps and oncogenes).
The Prognostic Value of MicroRNAs in Thyroid Cancers—A Systematic Review and Meta-Analysis
Authors: Silaghi Cristina Alina , Lozovanu Vera , Silaghi Horatiu , Georgescu Raluca Diana , Pop Cristina , Dobrean Anca , Georgescu Carmen Emanuela
Published: September 2020

Thyroid cancer (TC) includes various phenotypes, from indolent to highly aggressive cancer. The limitations of the current prognostication systems to predict the recurrence risk and the variability in expression of the genes involved in the thyroid carcinogenesis uncover the need for new prognostic biomarkers by taking into account potential epigenetic differences. We aimed to summarize the current knowledge regarding the prognostic impact of microRNAs (miRNAs) in TC. A literature search was conducted in PubMed, Embase, Scopus, and Web of Science databases. Both upregulated and downregulated miRNAs are significantly correlated with worse overall survival (hazard ratio (HR) = 5.94, 95% CI: 2.73–12.90, p < 0.001; HR = 0.51, 95% CI: 0.26–0.96, p = 0.048) disease/recurrence-free survival (HR = 1.58, 95% CI: 1.08–2.32, p = 0.003; HR = 0.37, 95%, CI: 0.24–0.60, p < 0.001). Sensitivity analysis revealed a significant association between the higher expression of miR-146b, miR-221, and miR-222 and the recurrence of papillary TC (OR = 9.11, 95% CI 3.00 to 27.52; p < 0.001; OR = 3.88, 95% CI 1.34 to 11.19, p < 0.001; OR = 6.56, 95% CI 2.75 to 15.64, p < 0.001). This research identified that miR-146b, miR-221, and miR-222 could serve as potential prognostic biomarkers in TC, particularly in PTC. Further studies are needed to strengthen these findings and sustain its clinical applicability.
Bone and Soft Tissue Sarcoma
Authors: Ruggiero Antonio
Published: September 2020

Bone and soft-tissue sarcomas are relatively rare tumors both in children and adults [...]
Triage May Improve Selection to Colonoscopy and Reduce the Number of Unnecessary Colonoscopies
Authors: Petersen Mathias M. , Ferm Linnea , Kleif Jakob , Piper Thomas B. , Rømer Eva , Christensen Ib J. , Nielsen Hans J.
Published: September 2020

Implementation of population screening for colorectal cancer by direct colonoscopy or follow-up colonoscopy after a positive fecal blood test has challenged the overall capacity of bowel examinations. Certain countries are facing serious colonoscopy capacity constraints, which have led to waiting lists and long time latency of follow-up examinations. Various options for improvement are considered, including increased cut-off values of the fecal blood tests. Results from major clinical studies of blood-based, cancer-associated biomarkers have, however, led to focus on a Triage concept for improved selection to colonoscopy. The Triage test may include subject age, concentration of hemoglobin in a feces test and a combination of certain blood-based cancer-associated biomarkers. Recent results have indicated that Triage may reduce the requirements for colonoscopy by around 30%. Such results may be advantageous for the capacity, the healthcare budgets and in particular, the subjects, who do not need an unnecessary, unpleasant and risk-associated bowel examination.
Radical Carbonylative Synthesis of Heterocycles by Visible Light Photoredox Catalysis
Authors: Hu Xiao-Qiang , Liu Zi-Kui , Xiao Wen-Jing
Published: September 2020

Visible light photocatalytic radical carbonylation has been established as a robust tool for the efficient synthesis of carbonyl-containing compounds. Acyl radicals serve as the key intermediates in these useful transformations and can be generated from the addition of alkyl or aryl radicals to carbon monoxide (CO) or various acyl radical precursors such as aldehydes, carboxylic acids, anhydrides, acyl chlorides or α-keto acids. In this review, we aim to summarize the impact of visible light-induced acyl radical carbonylation reactions on the synthesis of oxygen and nitrogen heterocycles. The discussion is mainly categorized based on different types of acyl radical precursors.
The Demonstration of the Superiority of the Dual Ni-Based Catalytic System for the Adjustment of the H2/CO Ratio in Syngas for Green Fuel Technologies
Authors: Sangsong Suntorn , Ratana Tanakorn , Tungkamani Sabaithip , Sornchamni Thana , Phongaksorn Monrudee , Croiset Eric
Published: September 2020

A novel dual Ni-based catalytic process (DCP) to control the H2/CO ratio of 2 in the syngas product within one step at temperature <700 °C was created and constructed. With the sequence of the catalysts located in the single reactor, the endothermic combined steam and CO2 reforming of methane (CSCRM) reaction and the exothermic ultra-high-temperature water–gas shift (UHT-WGS) reaction work continuously. During the process, the H2/CO ratio is raised suddenly at UHT-WGS after the syngas is produced from CSCRM, and CSCRM utilizes the heat released from UHT-WGS. Due to these features, DCP is more compact, enhances energy efficiency, and thus decreases the capital cost compared to reformers connecting with shift reactors. To prove this propose, the DCP tests were done in a fixed-bed reactor under various conditions (temperature = 500, 550, and 600 °C; the feed mixture (CH4, CO2, H2O, and N2) with H2O/(CH4 + CO2) ratio = 0.33, 0.53, and 0.67). According to the highest CH4 conversion (around 65%) with carbon tolerance, the recommended conditions for producing syngas with the H2/CO ratio of 2 as a feedstock of Fischer–Tropsch synthesis include the temperature of 600 °C and the H2O/(CH4 + CO2) ratio of 0.53.
The Amazonian Red Side-Necked Turtle Rhinemys rufipes (Spix, 1824) (Testudines, Chelidae) Has a GSD Sex-Determining Mechanism with an Ancient XY Sex Microchromosome System
Authors: Viana Patrik F. , Feldberg Eliana , Cioffi Marcelo B. , de Carvalho Vinicius Tadeu , Menezes Sabrina , Vogt Richard C. , Liehr Thomas , Ezaz Tariq
Published: September 2020

The Amazonian red side-necked turtle Rhynemis rufipes is an endemic Amazonian Chelidae species that occurs in small streams throughout Colombia and Brazil river basins. Little is known about various biological aspects of this species, including its sex determination strategies. Among chelids, the greatest karyotype diversity is found in the Neotropical species, with several 2n configurations, including cases of triploidy. Here, we investigate the karyotype of Rhinemys rufipes by applying combined conventional and molecular cytogenetic procedures. This allowed us to discover a genetic sex-determining mechanism that shares an ancestral micro XY sex chromosome system. This ancient micro XY system recruited distinct repeat motifs before it diverged from several South America and Australasian species. We propose that such a system dates back to the earliest lineages of the chelid species before the split of South America and Australasian lineages.
Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast
Authors: Lamas Iker , Weber Nathalie , Martin Sophie G.
Published: September 2020

The small GTPase Cdc42 is critical for cell polarization in eukaryotic cells. In rod-shaped fission yeast Schizosaccharomyces pombe cells, active GTP-bound Cdc42 promotes polarized growth at cell poles, while inactive Cdc42-GDP localizes ubiquitously also along cell sides. Zones of Cdc42 activity are maintained by positive feedback amplification involving the formation of a complex between Cdc42-GTP, the scaffold Scd2, and the guanine nucleotide exchange factor (GEF) Scd1, which promotes the activation of more Cdc42. Here, we use the CRY2-CIB1 optogenetic system to recruit and cluster a cytosolic Cdc42 variant at the plasma membrane and show that this leads to its moderate activation also on cell sides. Surprisingly, Scd2, which binds Cdc42-GTP, is still recruited to CRY2-Cdc42 clusters at cell sides in individual deletion of the GEFs Scd1 or Gef1. We show that activated Cdc42 clusters at cell sides are able to recruit Scd1, dependent on the scaffold Scd2. However, Cdc42 activity is not amplified by positive feedback and does not lead to morphogenetic changes, due to antagonistic activity of the GTPase activating protein Rga4. Thus, the cell architecture is robust to moderate activation of Cdc42 at cell sides.
Ionocytes and CFTR Chloride Channel Expression in Normal and Cystic Fibrosis Nasal and Bronchial Epithelial Cells
Authors: Scudieri Paolo , Musante Ilaria , Venturini Arianna , Guidone Daniela , Genovese Michele , Cresta Federico , Caci Emanuela , Palleschi Alessandro , Poeta Marco , Santamaria Francesca , Ciciriello Fabiana , Lucidi Vincenzina , Galietta Luis J. V.
Published: September 2020

The airway epithelium contains ionocytes, a rare cell type with high expression of Forkhead Box I1 (FOXI1) transcription factor and Cystic Fibrosis Transmembrane conductance Regulator (CFTR), a chloride channel that is defective in cystic fibrosis (CF). Our aim was to verify if ionocyte development is altered in CF and to investigate the relationship between ionocytes and CFTR-dependent chloride secretion. We collected nasal cells by brushing to determine ionocyte abundance. Nasal and bronchial cells were also expanded in vitro and reprogrammed to differentiated epithelia for morphological and functional studies. We found a relatively high (~3%) ionocyte abundance in ex vivo nasal samples, with no difference between CF and control individuals. In bronchi, ionocytes instead appeared very rarely as previously reported, thus suggesting a possible proximal–distal gradient in human airways. The difference between nasal and bronchial epithelial cells was maintained in culture, which suggests an epigenetic control of ionocyte development. In the differentiation phase of the culture procedure, we used two media that resulted in a different pattern of CFTR expression: confined to ionocytes or more broadly expressed. CFTR function was similar in both conditions, thus indicating that chloride secretion equally occurs irrespective of CFTR expression pattern.
An Evolutionary Cancer Epigenetic Approach Revealed DNA Hypermethylation of Ultra-Conserved Non-Coding Elements in Squamous Cell Carcinoma of Different Mammalian Species
Authors: Morandi Luca , Sabattini Silvia , Renzi Andrea , Rigillo Antonella , Bettini Giuliano , Dervas Eva , Schauer Alexandria , Morandi Marco , Gissi Davide B. , Tarsitano Achille , Evangelisti Stefania , Tonon Caterina
Published: September 2020

Background: Ultra-conserved non-coding elements (UCNEs) are genomic sequences that exhibit > 95% sequence identity between humans, mammals, birds, reptiles, and fish. Recent findings reported their functional role in cancer. The aim of this study was to evaluate the DNA methylation modifications of UNCEs in squamous cell carcinoma (SCC) from different mammal species. Methods: Fifty SCCs from 26 humans, 17 cats, 3 dogs, 1 horse, 1 bovine, 1 badger, and 1 porcupine were investigated. Fourteen feline stomatitis and normal samples from 36 healthy human donors, 7 cats, 5 dogs, 5 horses, 2 bovines and 1 badger were collected as normal controls. Bisulfite next generation sequencing evaluated the DNA methylation level from seven UCNEs (uc.160, uc.283, uc.416, uc.339, uc.270, uc.299, and uc.328). Results: 57/59 CpGs were significantly different according to the Kruskal–Wallis test (p < 0.05) comparing normal samples with SCC. A common DNA hypermethylation pattern was observed in SCCs from all the species evaluated in this study, with an increasing trend of hypermethylation starting from normal mucosa, through stomatitis to SCC. Conclusions: Our findings indicate that UCNEs are hypermethylated in human SCC, and this behavior is also conserved among different species of mammals.
Understanding School-Aged Childhood Obesity of Body Mass Index: Application of the Social-Ecological Framework
Authors: Noh Keeyoon , Min Jihyun Jane
Published: September 2020

In order to understand the prevalence of school-aged childhood obesity in the United States and suggest better methods to prevent and treat the public health problem, we examined it with significant and identifiable factors within the social-ecological model. To investigate the association between social-ecological factors and child obesity/overweight (BMI), we used the 5th wave of the Fragile Families and Child Wellbeing Study. The dataset included information on 9-year-old children. The sample size for our study was 2054. We utilized multiple normal distributions for missing values and the Ordinary Least Square regression analysis. Black and Hispanic children were more likely to be obese/overweight than White children; children with higher physical activity were negatively associated with higher obesity; older mothers were more likely to be associated with children’s obesity; family structure was also significantly related to the likelihood of childhood obesity; finally, school environment was significantly associated with child obesity. To combat childhood obesity, more school physical activities should be implemented, such as increasing physical education opportunities as well as building more sizable playgrounds and accessible recreation facilities at school and in communities. School environments also should be pleasant and safe for children. Health practitioners need to assess home environments to intervene for children’s health.
Effect of Fluorine Incorporation on DLC Films Deposited by Pulsed Cathodic Arc Deposition on Nitrile Butadiene Rubber and Polyurethane Rubber Substrates
Authors: Zhang Lijie , Zong Xuemei , Guo Fei , He Bing , Yuan Xiaoming
Published: September 2020

Diamond-like carbon (DLC) and fluorinated diamond-like carbon (F-DLC) films were deposited via pulsed cathodic arc deposition on pretreated nitrile butadiene rubber (NBR) and polyurethane (PU) rubber substrates. Both DLC and F-DLC films showed a more than 50% decrease in coefficients of friction compared to uncoated NBR and PU rubber substrates. The incorporation of fluorine was found to have little influence on the film coefficient of friction. However, a decrease in film wettability was overserved in the F-DLC films compared to the DLC films.
Review of the Application of Graphene-Based Coatings as Anticorrosion Layers
Authors: Ollik Karolina , Lieder Marek
Published: September 2020

Due to the excellent properties of graphene, including flexibility that allows it to adjust to the curvature of the substrate surface, chemical inertness, and impermeability, graphene is used as an anticorrosion layer. In this review, we present the current state-of-the-art in the application of graphene in the field of protective coatings. This review provides detailed discussions about the protective properties of graphene coatings deposited by different methods, graphene-based organic coatings, the modification of graphene-based coatings, and the effects of graphene functionalization on the corrosion resistance of protective coatings.
Large Angle Forward Diffraction by Chiral Liquid Crystal Gratings with Inclined Helical Axis
Authors: Stebryte Migle , Nys Inge , Ussembayev Yera Ye. , Beeckman Jeroen , Neyts Kristiaan
Published: September 2020

A layer of chiral liquid crystal (CLC) with a photonic bandgap in the visible range has excellent reflective properties. Recently, two director configurations have been proposed in the literature for CLC between two substrates with periodic photo-alignment: one with the director parallel to the substrates and one with the director in the bulk parallel to the tilted plane. The transmission experiments under large angles of incidence (AOI) presented in this work prove that, in the bulk, the director does not remain parallel with the substrates. Because of the inclined helical axis, the full reflection band can be observed at a smaller AOI than in planar CLC. For sufficiently large AOI, the reflection of diffracted light is prohibited by total internal reflection and efficient diffraction occurs in the forward direction.
Prediction of Properties of FRP-Confined Concrete Cylinders Based on Artificial Neural Networks
Authors: Ahmad Afaq , Plevris Vagelis , Khan Qaiser-uz-Zaman
Published: September 2020

Recently, the use of fiber-reinforced polymers (FRP)-confinement has increased due to its various favorable effects on concrete structures, such as an increase in strength and ductility. Therefore, researchers have been attracted to exploring the behavior and efficiency of FRP-confinement for concrete structural elements further. The current study investigates improved strength and strain models for FRP confined concrete cylindrical elements. Two new physical methods are proposed for use on a large preliminary evaluated database of 708 specimens for strength and 572 specimens for strain from previous experiments. The first approach is employing artificial neural networks (ANNs), and the second is using the general regression analysis technique for both axial strength and strain of FRP-confined concrete. The accuracy of the newly proposed strain models is quite satisfactory in comparison with previous experimental results. Moreover, the predictions of the proposed ANN models are better than the predictions of previously proposed models based on various statistical indices, such as the correlation coefficient (R) and mean square error (MSE), and can be used to assess the members at the ultimate limit state.
Diagnosing Organic Causes of Schizophrenia Spectrum Disorders: Findings from a One-Year Cohort of the Freiburg Diagnostic Protocol in Psychosis (FDPP)
Authors: Endres Dominique , Matysik Miriam , Feige Bernd , Venhoff Nils , Schweizer Tina , Michel Maike , Meixensberger Sophie , Runge Kimon , Maier Simon J. , Nickel Kathrin , Bechter Karl , Urbach Horst , Domschke Katharina , Tebartz van Elst Ludger
Published: September 2020

Introduction: Secondary schizophrenia spectrum disorders (SSDs) have clearly identifiable causes. The Department for Psychiatry and Psychotherapy at the University Hospital Freiburg has continued to expand its screening practices to clarify the organic causes of SSDs. This retrospective analysis was carried out to analyze whether a comprehensive organic diagnostic procedure could be informative in patients with SSDs. Methods and Participants: The “Freiburg Diagnostic Protocol in Psychosis” (FDPP) included basic laboratory analyses (e.g., thyroid hormones), metabolic markers, pathogens, vitamin status, different serological autoantibodies, rheumatic/immunological markers (e.g., complement factors), cerebrospinal fluid (CSF) basic and antineuronal antibody analyses, as well as cranial magnetic resonance imaging (cMRI) and electroencephalography (EEG). The findings of 76 consecutive patients with SSDs (55 with paranoid–hallucinatory; 14 with schizoaffective; 4 with hebephrenic; and 1 each with catatonic, acute polymorphic psychotic, and substance-induced psychotic syndromes) were analyzed. Results: Overall, vitamin and trace element deficiency was identified in 92%. Complement factor analyses detected reduced C3 levels in 11%. Immunological laboratory alterations were detected in 76%. CSF analysis revealed general alterations in 54% of the patients, mostly with signs of blood–brain barrier dysfunction. cMRI analyses showed chronic inflammatory lesions in 4%. Combination of EEG, cMRI, and CSF revealed alterations in 76% of the patients. In three patients, autoimmune psychosis was suspected (4%). Discussion: On the basis of these findings, we conclude that a comprehensive diagnostic procedure according to the FDPP in patients with SSD is worthwhile, considering the detection of secondary, organic forms of SSDs, as well as alterations in “modulating factors” of the disease course, such as vitamin deficiency. Larger studies using comprehensive diagnostic protocols are warranted to further validate this approach.
Association between EGFR Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer
Authors: Lin Ching-Hsiung , Yang Po-Jen , Lin Sheng-Hao , Yeh Kun-Tu , Tsao Thomas Chang-Yao , Chen Yu-En , Lin Shu-Hui , Yang Shun-Fa
Published: September 2020

EGFR mutation status is considered as an important predictor of therapeutic responsiveness in non-small-cell lung carcinoma patients. Recent evidence suggests that antioxidant gene polymorphisms are potential predictors of lung cancer risk. Thus, stratification of EGFR mutation-related phenotypes by antioxidant gene polymorphism status can be an effective approach in terms of improving the prognosis of lung cancer patients. The present study was designed to evaluate the distribution frequency of antioxidant gene polymorphisms in lung adenocarcinoma, as well as its association with hotspot EGFR mutations. The study findings revealed that a statistically significant association exists between EGFR L858R mutation and AG + GG genotypes of SOD rs4880 polymorphism. Furthermore, the subgroup analysis data revealed that compared to AA genotype of SOD rs4880, AG + GG genotypes were significantly associated with advanced cancer stage and distant metastasis. Taken together, these findings can be utilized clinically to predict cancer aggressiveness, metastatic, potential and therapeutic responsiveness of lung cancer patients.
Life’s Energy and Information: Contrasting Evolution of Volume- versus Surface-Specific Rates of Energy Consumption
Authors: Makarieva Anastassia M. , Nefiodov Andrei V. , Li Bai-Lian
Published: September 2020

As humanity struggles to find a path to resilience amidst global change vagaries, understanding organizing principles of living systems as the pillar for human existence is rapidly growing in importance. However, finding quantitative definitions for order, complexity, information and functionality of living systems remains a challenge. Here, we review and develop insights into this problem from the concept of the biotic regulation of the environment developed by Victor Gorshkov (1935–2019). Life’s extraordinary persistence—despite being a strongly non-equilibrium process—requires a quantum-classical duality: the program of life is written in molecules and thus can be copied without information loss, while life’s interaction with its non-equilibrium environment is performed by macroscopic classical objects (living individuals) that age. Life’s key energetic parameter, the volume-specific rate of energy consumption, is maintained within universal limits by most life forms. Contrary to previous suggestions, it cannot serve as a proxy for “evolutionary progress”. In contrast, ecosystem-level surface-specific energy consumption declines with growing animal body size in stable ecosystems. High consumption by big animals is associated with instability. We suggest that the evolutionary increase in body size may represent a spontaneous loss of information about environmental regulation, a manifestation of life’s algorithm ageing as a whole.
Distributed Attack Modeling Approach Based on Process Mining and Graph Segmentation
Authors: Chen Yuzhong , Liu Zhenyu , Liu Yulin , Dong Chen
Published: September 2020

Attack graph modeling aims to generate attack models by investigating attack behaviors recorded in intrusion alerts raised in network security devices. Attack models can help network security administrators discover an attack strategy that intruders use to compromise the network and implement a timely response to security threats. However, the state-of-the-art algorithms for attack graph modeling are unable to obtain a high-level or global-oriented view of the attack strategy. To address the aforementioned issue, considering the similarity between attack behavior and workflow, we employ a heuristic process mining algorithm to generate the initial attack graph. Although the initial attack graphs generated by the heuristic process mining algorithm are complete, they are extremely complex for manual analysis. To improve their readability, we propose a graph segmentation algorithm to split a complex attack graph into multiple subgraphs while preserving the original structure. Furthermore, to handle massive volume alert data, we propose a distributed attack graph generation algorithm based on Hadoop MapReduce and a distributed attack graph segmentation algorithm based on Spark GraphX. Additionally, we conduct comprehensive experiments to validate the performance of the proposed algorithms. The experimental results demonstrate that the proposed algorithms achieve considerable improvement over comparative algorithms in terms of accuracy and efficiency.
Reinforcement Learning Based Passengers Assistance System for Crowded Public Transportation in Fog Enabled Smart City
Authors: Neelakantam Gone , Onthoni Djeane Debora , Sahoo Prasan Kumar
Published: September 2020

Crowding in city public transportation systems is a primary issue that causes delay in the mobility of passengers. Moreover, scheduled and unscheduled events in a city lead to excess crowding situations at the metro or bus stations. The Internet of Things (IoT) devices could be used for data collection, which are related to crowding situations in a smart city. The fog computing data centers located in different zones of a smart city can process and analyze the collected data to assist the passengers how to commute smoothly with minimum waiting time in the crowded situation. In this paper, Q-learning based passengers assistance system is designed to assist the commuters in finding less crowded bus and metro stations to avoid long queues of waiting. The traffic congestion and crowded situation data are processed in the fog computing data centers. From our experimental results, it is found that our proposed method can achieve higher reward values, which can be used to minimize the passengers’ waiting time with minimum computational delay as compared to the cloud computing platform.
A V-Band Phase-Locked Loop with a Novel Phase-Frequency Detector in 65 nm CMOS
Authors: Abbas Waseem , Mehmood Zubair , Seo Munkyo
Published: September 2020

A 65–67 GHz phase-locked loop (PLL) with a novel low power phase-frequency detector (PFD) in 65 nm LP CMOS is presented. The PLL consists of a V-band voltage-controlled oscillator (VCO), a divide-by-two injection-locked frequency divider (ILFD), and a current-mode logic (CML) divider chain. A charge pump (CP) and a 2nd-order loop filter are used with PFD for VCO tuning. The PFD is implemented with 16 transistors with dead-zone-free capability. The measured locking range of the PLL is from 65.15 to 67.4 GHz, with −11.5 dBm measured output power at 66.05 GHz while consuming 88 mW. The measured phase noise at 1 MHz offset is −84.43 dBc/Hz. The chip area of the PLL is 0.84 mm2 including probing pads. The proposed PLL can be utilized as a frequency synthesizer for carrier signal generation in IEEE 802.11ad standard high data rate transceiver circuits.
A Computationally Efficient Algorithm for Feedforward Active Noise Control Systems
Authors: Gaiotto Stefano , Laudani Antonino , Lozito Gabriele Maria , Riganti Fulginei Francesco
Published: September 2020

In this paper, a novel algorithm with high computational efficiency is proposed for the filter adaptation in a feedforward active noise control system. The proposed algorithm Zero Forcing Block Adaptive Filter (ZF-BAF) performs filter adaptation on a block-by-block basis in the frequency domain. Filtering is performed in the time domain on a sample-by-sample basis. Working in the frequency domain permits us to get sub-linear complexity, whereas filtering in the time domain minimizes the latency. Furthermore, computational burden is tunable to meet specific requirements about adaptation speed and processing load. No other parameter tuning according to the working condition is required. Computer simulations, performed in different realistic cases against other high-performing time and frequency-domain algorithms, show that achievable performances are comparable, or even better, with those of the algorithms perfectly tuned for each specific case. Robustness exhibited in the tests suggests that performances are expected to be even better in a wide range of real cases where it is impossible to know a priori how to tune the algorithms.
IoT-Based Digital Twin for Energy Cyber-Physical Systems: Design and Implementation
Authors: Saad Ahmed , Faddel Samy , Mohammed Osama
Published: September 2020

With the emergence of distributed energy resources (DERs), with their associated communication and control complexities, there is a need for an efficient platform that can digest all the incoming data and ensure the reliable operation of the power system. The digital twin (DT) is a new concept that can unleash tremendous opportunities and can be used at the different control and security levels of power systems. This paper provides a methodology for the modelling of the implementation of energy cyber-physical systems (ECPSs) that can be used for multiple applications. Two DT types are introduced to cover the high-bandwidth and the low-bandwidth applications that need centric oversight decision making. The concept of the digital twin is validated and tested using Amazon Web Services (AWS) as a cloud host that can incorporate physical and data models as well as being able to receive live measurements from the different actual power and control entities. The experimental results demonstrate the feasibility of the real-time implementation of the DT for the ECPS based on internet of things (IoT) and cloud computing technologies. The normalized mean-square error for the low-bandwidth DT case was 3.7%. In the case of a high-bandwidth DT, the proposed method showed superior performance in reconstructing the voltage estimates, with 98.2% accuracy from only the controllers’ states.
Development of a DC-Side Direct Current Controlled Active Ripple Filter for Eliminating the Double-Line-Frequency Current Ripple in a Single-Phase DC/AC Conversion System
Authors: Chen Ying-Chieh , Chen Liang-Rui , Lai Ching-Ming , Lin Yuan-Chih , Kuo Ting-Jung
Published: September 2020

The objective of this paper is to propose an active ripple filter (ARF) using the patented DC-side direct current control for eliminating the double-line-frequency current ripple in a single-phase DC/AC conversion system. The proposed ARF and its control strategies can not only prolong the usage life of the DC energy source but also improve the DC/AC system performance. At first, the phenomena of double-line-frequency current ripple and the operation principle of the ARF are illustrated. Then, steady-state analysis, small-signal model, and control loop design of the ARF architecture are derived. The proposed control system includes: (1) a DC current control loop to provide the excellent ripple eliminating performance on the output of the DC energy source; (2) a voltage control loop for the high-side DC-bus voltage of the ARF to achieve good steady-state and transient-state responses; (3) a voltage feedforward loop for the low-side voltage of the ARF to cancel the voltage fluctuation caused by the instability of the DC energy source. Finally, the feasibility of the proposed concept can be verified by the system simulation, and the experimental results show that the nearly zero double-line-frequency current ripple on the DC-side in a single-phase DC/AC conversion system can be achieved.
Polysilane-Inserted Methylammonium Lead Iodide Perovskite Solar Cells Doped with Formamidinium and Potassium
Authors: Oku Takeo , Kandori Satsuki , Taguchi Masaya , Suzuki Atsushi , Okita Masanobu , Minami Satoshi , Fukunishi Sakiko , Tachikawa Tomoharu
Published: September 2020

Polysilane-inserted CH3NH3PbI3 perovskite photovoltaic devices combined with potassium and formamidinium iodides were fabricated and characterized. Decaphenylcyclopentasilane layers were inserted at the perovskite/hole transport interface and annealed across a temperature range of 180–220 °C. These polysilane-coated cells prevented PbI2 formation, and the conversion efficiencies were improved over extended periods of time.
Performance Assessment of Large Photovoltaic (PV) Plants Using an Integrated State-Space Average Modeling Approach
Authors: Nobile Giovanni , Vasta Ester , Cacciato Mario , Scarcella Giuseppe , Scelba Giacomo , Di Stefano Agnese Giuseppa Federica , Leotta Giuseppe , Pugliatti Paola Maria , Bizzarri Fabrizio
Published: September 2020

Distributed power converters represent a technical solution to improve the performance of large or utility-scale photovoltaic (PV) plants. Unfortunately, evaluation of the yield obtained in large PV fields by using distributed converters is a difficult task because of recurring partial unavailability, inaccuracy of power analyzers, operating constraints imposed by the Power Plant Controller and so on. To overcome such issues in real operating scenarios, a new modeling strategy has been introduced and validated in terms of computational complexity and accuracy. This approach is based on the state-space averaging technique which is applied to large PV plants with multiple conversion stages by performing some elaborations in order to get a final integrated model. The new modeling strategy has been tested in MatLab Simulink environment using data coming from a 300 MW PV plant located in Brazil representing the case study of this work. In this plant, one subfield is equipped with central inverters while another is with string inverters. The proposed model, whose accuracy is in the range from 2.2 to 2.7% with respect to the measured energy, effectively supports data analysis leading to a consistent performance assessment for the distributed conversion system. Final results highlight that string inverters ensure a gain of about 2% in terms of produced energy.
Study on the Coupling Effect of a Solar-Coal Unit Thermodynamic System with Carbon Capture
Authors: Wang Jixuan , Liu Wensheng , Meng Xin , Liu Xiaozhen , Gao Yanfeng , Yu Zuodong , Bai Yakai , Yang Xin
Published: September 2020

Based on the structural theory of thermo-economics, a 600 MW unit was taken as an example. An integration system which uses fuel gas heat and solar energy as a heat source for post-combustion carbon capture was proposed. The physical structure sketch and productive structure sketch were drawn and a thermo-economics model and cost model based on the definition of fuel-product were established. The production relation between units was analyzed, and the composition and distribution of the exergy cost and thermo-economic cost of each unit were studied. Additionally, the influence of the fuel price and equipment investment cost of the thermo-economic cost for each product was studied. The results showed that the main factors affecting the unit cost are the fuel exergy cost, component exergy efficiency, and irreversible exergy cost of each unit, and the main factors affecting the thermo-economics cost are the specific irreversible exergy cost and investment exergy cost. The main factors affecting the thermal economics of solar energy collectors and low-pressure economizers are the invested exergy cost, negentropy exergy cost, and irreversible exergy cost of each unit.
Frequency Response Improvement of PMSG Wind Turbines Using a Washout Filter
Authors: Shabestari Parisa M. , Mehrizi-Sani Ali
Published: September 2020

High integration of renewable energy resources, such as wind turbines, to the power grid decreases the power system inertia. To improve the frequency response of a low-inertia system, virtual inertia approach can be used. This letter proposes a control method to decrease the frequency transients and restore frequency to its nominal value. A wind turbine usually works based on maximum power point tracking (MPPT) curves to achieve the maximum power. In this letter, the proposed controller uses a non-MPPT method to leave power for frequency regulation during transients. Moreover, it uses a washout filter-based method to remove the steady-state error in the frequency. Simulation results in the PSCAD environment validate the improved performance of the proposed method during load changes by comparing it with the MPPT and non-MPPT methods.
Data-Based RC Dynamic Modelling to Assessing the In-Situ Thermal Performance of Buildings. Analysis of Several Key Aspects in a Simplified Reference Case toward the Application at On-Board Monitoring Level
Authors: Olazo-Gómez Yessenia , Herrada Héctor , Castaño Sergio , Arce Jesús , Xamán Jesús P. , Jiménez María José
Published: September 2020

This paper reports the application of RC dynamic models for assessing thermal performance of buildings from in-situ tests (obtaining the U value for the walls, and the UA value and gA value for the whole buildings). The following aspects which are relevant to this approach have been systematically analyzed: The effect of the solar radiation on the heat flux through the opaque walls versus the performance of the models including this effect, the optimum number of nodes required to represent the thermal systems, the assignment of inputs and outputs and the length of the test period. Additionally, several options modelling relevant effects using unmeasured variables were studied to evaluate the feasibility to reduce the cost and intrusiveness of the measurement devices required to obtain accurate results. Data series recorded under different experimental conditions were considered to analyze the robustness and validity of the results. The performance of the models for each of these different test conditions is discussed. The uncertainties estimated using the described method for the U values of the opaque walls, and the UA and gA values of the whole building, are, respectively, 2.8%, 4.2% and 2.3%. The feasibility to model relevant effects using unmeasured variables has been demonstrated. A simplified and well-known building has been used as a case study, reinforcing and complementing the validation criteria.
Seasonal Variation of Soil Respiration in the Mongolian Oak (Quercus mongolica Fisch. Ex Ledeb.) Forests at the Cool Temperate Zone in Korea
Authors: Kim Gyung Soon , Joo Seung Jin , Lee Chang Seok
Published: September 2020

To investigate the variation in seasonal soil respiration (SR) as a function of soil temperature (Ts) and soil water content (SWC) in Mongolian oak (Quercus mongolica) forests in urban (Mt. Nam) and well-reserved (Mt. Jeombong) areas in South Korea, we conducted continuous field measurements of SR and other environmental parameters (Ts and SWC) using an automated chamber system. Overall, the SR rates in both stands were strongly correlated with the Ts variable during all seasons. However, abrupt fluctuations in SR were significantly related to episodic increases in SWC on a short time scale during the growing season. The integrated optimal regression models for SR using Ts at a depth of 5 cm and SWC at a depth of 15 cm yielded the following: the SR rate in Mt. Nam = SR(Ts) + ΔSR(Ts) = 104.87 exp(0.1108Ts) − 10.09(SWC)2 + 604.2(SWC) − 8627.7 for Ts ≥ 0 °C, and the SR rate in Mt. Jeombong = SR(Ts) + ΔSR(Ts) = 95.608 exp(0.1304Ts) − 33.086(SWC)2 + 1949.2(SWC) − 28499 for Ts ≥ 0 °C. In both cases, SR = 0 for Ts < 0 °C. As per these equations, the estimated annual total SRs were 1339.4 g C m−2 for Mt. Nam and 1003.0 g C m−2 for Mt. Jeombong. These values were quite similar to the measured values in field. Our results demonstrate that the improved empirical equation is an effective tool for estimating and predicting SR variability and provide evidence that the SR of Q. mongolica forests in the cool temperate zone of Korean Peninsula depends on Ts and SWC variables.
Direct Versus Indirect Tree Ring Reconstruction of Annual Discharge of Chemora River, Algeria
Authors: Meko David , Touchan Ramzi , Kherchouche Dalila , Slimani Said
Published: September 2020

Annual river discharge is a critical variable for water resources planning and management. Tree rings are widely used to reconstruct annual discharge, but errors can be large when tree growth fails to respond commensurately to hydrologically important seasonal components of climate. This paper contrasts direct and indirect reconstruction as statistical approaches to discharge reconstruction for the Chemora River, in semi-arid northeastern Algeria, and explores indirect reconstruction as a diagnostic tool in reconstruction error analysis. We define direct reconstruction as predictions from regression of annual discharge on tree ring data, and indirect reconstruction as predictions from a four-stage process: (1) regression of precipitation on tree rings, (2) application of the regression model to get reconstructed precipitation for grid cells over the basin, (3) routing of reconstructed precipitation through a climatological water balance (WB) model, and (4) summing model runoff over cells to get the reconstructed discharge at a gage location. For comparative purposes, the potential predictors in both modeling approaches are the same principal components of tree ring width chronologies from a network of drought-sensitive sites of Pinus halepensis and Cedrus atlantica in northern Algeria. Results suggest that both modeling approaches can yield statistically significant reconstructions for the Chemora River. Greater accuracy and simplicity of the direct method are countered by conceptual physical advantages of the indirect method. The WB modeling inherent to the indirect method is useful as a diagnostic tool in error analysis of discharge reconstruction, points out the low and declining importance of snowmelt to the river discharge, and gives clues to the cause of severe underestimation of discharge in the outlier high-discharge year 1996. Results show that indirect reconstruction would benefit most in this basin from tree ring resolution of seasonal precipitation.