bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of CNTs Doped Nickel Copper-Sulfides Composite Electrode Material for High-Performance Battery-Supercapacitor Hybrid Device
Authors: Khan Rizwan , Imran Muhammad , Afzal Amir Muhammad , Iqbal Muhammad Waqas , Mumtaz Sohail , Munnaf Shaik Abdul , Islam Mohammad Shahidul , Sajad Rida , Muzaffar Nimra , Yaqoob M. Z.
Published: October 2023

The hybrid supercapacitor combines the outstanding energy density characteristics of batteries with the remarkable durability and unique power characteristics of supercapacitors (SCs). Herein, a hydrothermal technique was applied to produce nickel-copper sulfide (NiCuS), which was later physically embedded into carbon nanotubes. In this study, a three and two electrode measurement systems were studied. To confirm the battery type nature of the electrode materials, a three-electrode assembly was used. For hybrid device, a two-electrode measurement scheme was employed. In the three-electrode setup, the NiCuS@CNT composite revealed a superior specific capacity (Qs) of 1110.0 C g−1. The NiCuS@CNT//AC nanocomposite based hybrid device established a remarkable Qs of 620.9 C g−1. Additionally, the NiCuS@CNT//AC exhibited a remarkable energy density (Ed) of 29.5 Wh kg−1 and a power density (Pd) of 2165.0 W kg−1.This composite material is distinguished for its remarkable capacity retention, maintaining an amazing 88.2% of its capacity after 8000 cycles. This emphasizes its continued stability and the possibility of having a longer operating lifespan. By advancing energy storage technologies, this dynamic integration might provide brand-new, exciting opportunities.
High Quantum Yield Sensitization of Single Crystal TiO2 Electrodes with CsPbBr3 Nanocrystals
Authors: She Yuqi , Martin Thomas Peter , Parkinson Bruce A.
Published: October 2023

Lead halide perovskites are promising materials for solar cells and photodetectors. Nanocrystals of this family of perovskites also have distinct properties. In this study we report the attainment of high quantum yield sensitized photocurrents from stabilized CsPbBr3 perovskite nanocrystals thermally evaporated onto doped single crystal rutile (110) TiO2 electrodes. Sensitized photocurrent stabilization was achieved by capping the nanocrystals with a thin NiOx layer and a Au carrier transport and protection layers respectively as well as the judicious choice of solvent and electrolyte.
Satellite Fast Maneuver Control Technology Based on Parallel System
Authors: Gao Youtao , Guo Jinghe , You Zhicheng , Dong Zezheng , Cheng Yi
Published: October 2023

An on-orbit thrust estimation method of satellite based on parallel system, which can achieve high-efficiency and high-precision thrust estimation, is proposed. A complete satellite maneuvering parallel system framework is constructed. Initially, a real-time artificial model, which is consistent with the actual system, is established. The injection time of maneuvering control is estimated optimally based on the modification of the artificial model with the specific injection time treated as the optimization parameter. The jet time, with the minimum maneuvering error, is obtained. Then, a maneuver strategy is designed and fed back to the actual system. The method based on a parallel system with jet time as the optimal parameter has higher control accuracy than the previous maneuvering control, which only considers the speed increment. Simulation results show that the terminal error of the first maneuver using the parallel system method is less than 100 meters for a maneuvering mission of tens of kilometers.
Value Chain Analysis of Highland Bamboo (Yushania alpina) in Banja District, Awi Zone, Ethiopia
Authors: Mengstu Mulat , Alemu Asmamaw , Worku Chernet , Bezie Sosina
Published: October 2023

Bamboo is one of the most important vegetation resources in highlands of Ethiopia. In Ethiopia, understanding the socioeconomic significance of bamboo resources and linkages between policy makers and other organizations is a persistent issue for the expansion of bamboo industry. This study aims at analyzing the value chain of highland bamboo originating from Banja district, Awi zone, Ethiopia. Specifically, it investigates the current value chain structure of highland bamboo and the role of actors and identifies the existing upgrading strategies along the chain, estimates the market performance, analyzes the determinants that affect the market supply of highland bamboo, and analyzes the governance structure along the highland bamboo value chain. Primary data were collected from direct value chain actors such as 122 sampled households, 13 traders, 16 processors, and 30 final users through semistructured interview schedules, key informant interviews, focus group discussions, and personal observation. Descriptive statistics, multiple linear regression, and value chain analysis were employed to analyze the data. Government offices and international network of bamboo and rattan and micro and small enterprises were support service providers. The governance structures in the bamboo value chain differ from one stage to the other stage. The result of multiple linear regression model indicated that the land size allocated for bamboo plantation, number of culm harvested, access of market information, and silviculture management practice positively affected the market supply of bamboo culm, whereas distance to the market affected the market supply of bamboo culm negatively and significantly. Based on the findings of this study, designing policies help to increase farmers’ knowledge and skills through capacity building and help to improve information access, silviculture management practice, and market supply of culm.
Design and Analysis of an Expert System for the Detection and Recognition of Criminal Faces
Authors: Gupta Rishi , Gupta Amit Kumar , Panwar Deepak , Jain Ashish , Chakraborty Partha
Published: October 2023

The process of identifying a person using their facial traits is referred to as face recognition, and it is a form of biometric identification. The use of facial recognition might range from that of an entertainment tool to one of a security tool. Even while other forms of biometric identification, such as fingerprints and iris scans, are reliable, they require the active participation of an individual. As a result, criminals cannot rely on them as the most reliable means of verification. When a criminal database, which stores the individual details of a criminal, and facial recognition technology are brought together, it can identify a criminal who is depicted in an image or seen in a video feed. Not only does a criminal recognition system needs to have a high level of accuracy, but it also needs to be able to adapt to significant changes in lighting, occlusion, aging, expressions, and other factors. In this study, they were analyzed and compared with the many methods of face detection and face recognition, such as HAAR cascades, local binary patterns histogram, support vector machines, convolutional neural networks, and ResNet-34. These methods include a variety of different approaches to recognizing faces. An analysis of these strategies is also conducted and then put into practice to those that seem to be the most effective for the designed criminal recognition system. In addition to that, a variety of uses of this criminal recognition in the real world are also discussed.
Base-Catalyzed Polymerization of a Substituted Methylenebicyclo[3.3.1]nonane
Authors: Thakur Sujeet Kumar , Raviteja Seera , Guru Row Tayur N. , Eswaran Sambasivan Venkat
Published: October 2023

Lignite humic acid on reaction with formaldehyde and aqueous alkali led to a polybicyclo[3.3.1]nonane. This was characterized spectroscopically using mass spectrometry, FT-IR, powder X-ray diffraction, TEM, and NMR studies (1H-NMR, CP-MAS-SS-NMR) which though challenging were useful for confirming the structure of the BCN polymer. The product showed an envelope peak in its MALDI-MS spectrum, based on which

M

̅

n

,

M

̅

w

, and polydispersity index have been calculated. Based on the NMR spectrum of intermediate, the presence of the N-formyl group has been shown in it. The new polymer could be useful in agriculture in water-deficient areas. Most papers on humic acids include only broad and general information like elemental analysis (occasionally TEM, SEM, TGA, DSC, etc.). Very complicated structures have been proposed by scientists earlier. Only in very recent years, it has been recognized that these are relatively small molecules which masquerade as supramolecular structures. It is pointed out that most papers do not put down the structure of the compound and provide no concrete proof for proposing such structures. The novelty of our work is that we have characterized the precise molecular weights based on mass spectrometry and NMR spectroscopy along with a well-defined structure. This is not the case in most other publications.
An Impulse-Quantizing Synchronization Approach for Mixed Continuous-Discrete Complex Networks
Authors: Hu Na , Li Luyan , Bin Honghua , Huang Zhenkun
Published: October 2023

This paper presents synchronization of mixed continuous-discrete complex network via impulse-quantizing approach. A delay-partitioning group strategy is proposed and impulse-quantizing control is designed to derive theoretical criteria ensuring scale-type synchronization of complex networks. Our results show that synchronization of mixed continuous-discrete complex networks can be realized by controlling delay-partitioning subgroup nodes with impulsive quantization. The theoretical results give scale-limited sufficient conditions for quantized synchronization relying on control gains, impulsive intervals, and delays. A numerical simulation is given to demonstrate the effectiveness of the theoretical results.
Figure S7 from Targeting the Immunoglobulin IGSF9 Enhances Antitumor T-cell Activity and Sensitivity to Anti–PD-1 Immunotherapy
Authors: Liu Yifan , Wang Hongying , Zhao Xinyu , Zhang Jiashen , Zhao Zhiling , Lian Xia , Zhang Juan , Kong Feng , Hu Tao , Wang Ting , Li Xiaohua , Wang Lei , Wang Dapeng , Li Chunling , Luan Huiwen , Liu Xiaoli , Wang Chunyan , Jiang Yun , Li Xiaomin , Li Fangmin , Ji Shuhao , Wang Yaopeng , Li Zunling
Published: October 2023

Anti-IGSF9 reversed the inhibition of T cells mediated by IGSF9-ECD.
Supplementary Fig. 4 from Spatial Profiling of Circular RNAs in Cancer Reveals High Expression in Muscle and Stromal Cells
Authors: García-Rodríguez Juan L. , Korsgaard Ulrik , Ahmadov Ulvi , Jarlstad Olesen Morten T. , Dietrich Kim-Gwendolyn , Hansen Emma B. , Vissing Stine M. , Ulhøi Benedichte P. , Dyrskjøt Lars , Sørensen Karina D. , Kjems Jørgen , Hager Henrik , Kristensen Lasse S.
Published: October 2023

circRNAs expression patterns from tissue sub-compartments compared to colon cancer cell lines.
Nanostring normalized counts for circAbParts, circABR, circAKAP12, circCCDC66, circRBM23, circSLC8A1, circSPECC1,
circTNFRSF21, circZNF609, circCAMSAP1 and circXPO1 in each of the sub-compartments for each patient and compared to
4 different colon cancer cell lines.
Tables S10-S12 from Integrative Genomic Analyses Identify LncRNA Regulatory Networks across Pediatric Leukemias and Solid Tumors
Authors: Modi Apexa , Lopez Gonzalo , Conkrite Karina L. , Su Chun , Leung Tsz Ching , Ramanan Sathvik , Manduchi Elisabetta , Johnson Matthew E. , Cheung Daphne , Gadd Samantha , Zhang Jinghui , Smith Malcolm A. , Guidry Auvil Jaime M. , Meshinchi Soheil , Perlman Elizabeth J. , Hunger Stephen P. , Maris John M. , Wells Andrew D. , Grant Struan F.A. , Diskin Sharon J.
Published: October 2023

Table S10: Statistics for input and output variables of lncMod analysis (xls file), Table S11: Significantly dysregulated lncMod triplets, Table S12: lncRNA TF associations ranked by # target genes
Figure S8 from Integrative Genomic Analyses Identify LncRNA Regulatory Networks across Pediatric Leukemias and Solid Tumors
Authors: Modi Apexa , Lopez Gonzalo , Conkrite Karina L. , Su Chun , Leung Tsz Ching , Ramanan Sathvik , Manduchi Elisabetta , Johnson Matthew E. , Cheung Daphne , Gadd Samantha , Zhang Jinghui , Smith Malcolm A. , Guidry Auvil Jaime M. , Meshinchi Soheil , Perlman Elizabeth J. , Hunger Stephen P. , Maris John M. , Wells Andrew D. , Grant Struan F.A. , Diskin Sharon J.
Published: October 2023

Figure S8: RNA expression profiling following TBX2-AS1 and TBX2 knockdown in NLF
Supplementary Figure S4 from Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX
Authors: Singh Rumani , Yu Stacey , Osman Marwa , Inde Zintis , Fraser Cameron , Cleveland Abigail H. , Almanzar Nicole , Lim Chuan Bian , Joshi Gaurav N. , Spetz Johan , Qin Xingping , Toprani Sneh M. , Nagel Zachary , Hocking Matthew C. , Cormack Robert A. , Yock Torunn I. , Miller Jeffrey W. , Yuan Zhi-Min , Gershon Timothy , Sarosiek Kristopher A.
Published: October 2023

Supplementary Figure S4
Supplementary Figure S3 from Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX
Authors: Singh Rumani , Yu Stacey , Osman Marwa , Inde Zintis , Fraser Cameron , Cleveland Abigail H. , Almanzar Nicole , Lim Chuan Bian , Joshi Gaurav N. , Spetz Johan , Qin Xingping , Toprani Sneh M. , Nagel Zachary , Hocking Matthew C. , Cormack Robert A. , Yock Torunn I. , Miller Jeffrey W. , Yuan Zhi-Min , Gershon Timothy , Sarosiek Kristopher A.
Published: October 2023

Supplementary Figure S3
Supplementary Figure S2 from Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX
Authors: Singh Rumani , Yu Stacey , Osman Marwa , Inde Zintis , Fraser Cameron , Cleveland Abigail H. , Almanzar Nicole , Lim Chuan Bian , Joshi Gaurav N. , Spetz Johan , Qin Xingping , Toprani Sneh M. , Nagel Zachary , Hocking Matthew C. , Cormack Robert A. , Yock Torunn I. , Miller Jeffrey W. , Yuan Zhi-Min , Gershon Timothy , Sarosiek Kristopher A.
Published: October 2023

Supplementary Figure S2
Supplementary Figure S6 from Memory-like Differentiation, Tumor-Targeting mAbs, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer
Authors: Jacobs Miriam T. , Wong Pamela , Zhou Alice Y. , Becker-Hapak Michelle , Marin Nancy D. , Marsala Lynne , Foster Mark , Foltz Jennifer A. , Cubitt Celia C. , Tran Jennifer , Russler-Germain David A. , Neal Carly , Kersting-Schadek Samantha , Chang Lily , Schappe Timothy , Pence Patrick , McClain Ethan , Zevallos Jose P. , Rich Jason T. , Paniello Randal C. , Jackson Ryan S. , Pipkorn Patrik , Adkins Douglas R. , DeSelm Carl J. , Berrien-Elliott Melissa M. , Puram Sidharth V. , Fehniger Todd A.
Published: October 2023

Supplementary Figure 6. EphA2-CAR ML NK cells display enhanced functional responses against HPV positive and HPV negative HNSCC cell lines.
Supplementary Table S3 from Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
Authors: Sarén Tina , Ramachandran Mohanraj , Gammelgård Gustav , Lövgren Tanja , Mirabello Claudio , Björklund Åsa K. , Wikström Kristina , Hashemi Jamileh , Freyhult Eva , Ahlström Håkan , Amini Rose-Marie , Hagberg Hans , Loskog Angelica , Enblad Gunilla , Essand Magnus
Published: October 2023

Custom genes added for targeted single-cell sequencing
Supplementary Table S1 from Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer
Authors: Williams Christopher J.M. , Elliott Faye , Sapanara Nancy , Aghaei Faranak , Zhang Liping , Muranyi Andrea , Yan Dongyao , Bai Isaac , Zhao Zuo , Shires Michael , Wood Henry M. , Richman Susan D. , Hemmings Gemma , Hale Michael , Bottomley Daniel , Galvin Leanne , Cartlidge Caroline , Dance Sarah , Bacon Chris M. , Mansfield Laura , Young-Zvandasara Kathe , Sudan Ajay , Lambert Katy , Bibby Irena , Coupland Sarah E. , Montazeri Amir , Kipling Natalie , Hughes Kathryn , Cross Simon S. , Dewdney Alice , Pheasey Leanne , Leng Cathryn , Gochera Tatenda , Mangham D. Chas , Saunders Mark , Pritchard Martin , Stott Helen , Mukherjee Abhik , Ilyas Mohammad , Silverman Rafael , Hyland Georgina , Sculthorpe Declan , Thornton Kirsty , Gould Imogen , O'Callaghan Ann , Brown Nicholas , Turnbull Samantha , Shaw Lisa , Seymour Matthew T. , West Nicholas P. , Seligmann Jenny F. , Singh Shalini , Shanmugam Kandavel , Quirke Philip
Published: October 2023

Primer details
Supplementary Figure S3 from Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer
Authors: Williams Christopher J.M. , Elliott Faye , Sapanara Nancy , Aghaei Faranak , Zhang Liping , Muranyi Andrea , Yan Dongyao , Bai Isaac , Zhao Zuo , Shires Michael , Wood Henry M. , Richman Susan D. , Hemmings Gemma , Hale Michael , Bottomley Daniel , Galvin Leanne , Cartlidge Caroline , Dance Sarah , Bacon Chris M. , Mansfield Laura , Young-Zvandasara Kathe , Sudan Ajay , Lambert Katy , Bibby Irena , Coupland Sarah E. , Montazeri Amir , Kipling Natalie , Hughes Kathryn , Cross Simon S. , Dewdney Alice , Pheasey Leanne , Leng Cathryn , Gochera Tatenda , Mangham D. Chas , Saunders Mark , Pritchard Martin , Stott Helen , Mukherjee Abhik , Ilyas Mohammad , Silverman Rafael , Hyland Georgina , Sculthorpe Declan , Thornton Kirsty , Gould Imogen , O'Callaghan Ann , Brown Nicholas , Turnbull Samantha , Shaw Lisa , Seymour Matthew T. , West Nicholas P. , Seligmann Jenny F. , Singh Shalini , Shanmugam Kandavel , Quirke Philip
Published: October 2023

Scatterplot: AREG vs EREG
Supplementary Table S12 from Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
Authors: Sarén Tina , Ramachandran Mohanraj , Gammelgård Gustav , Lövgren Tanja , Mirabello Claudio , Björklund Åsa K. , Wikström Kristina , Hashemi Jamileh , Freyhult Eva , Ahlström Håkan , Amini Rose-Marie , Hagberg Hans , Loskog Angelica , Enblad Gunilla , Essand Magnus
Published: October 2023

List of antibodies and dyes used for functionality flow cytometry assays
Supplementary Figure S11 from Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
Authors: Sarén Tina , Ramachandran Mohanraj , Gammelgård Gustav , Lövgren Tanja , Mirabello Claudio , Björklund Åsa K. , Wikström Kristina , Hashemi Jamileh , Freyhult Eva , Ahlström Håkan , Amini Rose-Marie , Hagberg Hans , Loskog Angelica , Enblad Gunilla , Essand Magnus
Published: October 2023

Supplementary Figure S11. Expression of genes included in the single-cell polyfunctionality
strength index analysis in individual patients
Supplementary Table S4 from Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts
Authors: Todisco Gabriele , Creignou Maria , Bernard Elsa , Björklund Ann-Charlotte , Moura Pedro Luis , Tesi Bianca , Mortera-Blanco Teresa , Sander Birgitta , Jansson Monika , Walldin Gunilla , Barbosa Indira , Reinsbach Susanne E. , Hofman Isabel Juliana , Nilsson Christer , Yoshizato Tetsuichi , Dimitriou Marios , Chang David , Olafsdottir Svannildur , Venckute Larsson Sigita , Tobiasson Magnus , Malcovati Luca , Woll Petter , Jacobsen Sten Eirik W. , Papaemmanuil Elli , Hellström-Lindberg Eva
Published: October 2023

Variables significant for survival analysis in univariate analysis
Supplementary Table S1 from Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts
Authors: Todisco Gabriele , Creignou Maria , Bernard Elsa , Björklund Ann-Charlotte , Moura Pedro Luis , Tesi Bianca , Mortera-Blanco Teresa , Sander Birgitta , Jansson Monika , Walldin Gunilla , Barbosa Indira , Reinsbach Susanne E. , Hofman Isabel Juliana , Nilsson Christer , Yoshizato Tetsuichi , Dimitriou Marios , Chang David , Olafsdottir Svannildur , Venckute Larsson Sigita , Tobiasson Magnus , Malcovati Luca , Woll Petter , Jacobsen Sten Eirik W. , Papaemmanuil Elli , Hellström-Lindberg Eva
Published: October 2023

RNA Sequencing metrics.
Supplementary Figure S21 from Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts
Authors: Todisco Gabriele , Creignou Maria , Bernard Elsa , Björklund Ann-Charlotte , Moura Pedro Luis , Tesi Bianca , Mortera-Blanco Teresa , Sander Birgitta , Jansson Monika , Walldin Gunilla , Barbosa Indira , Reinsbach Susanne E. , Hofman Isabel Juliana , Nilsson Christer , Yoshizato Tetsuichi , Dimitriou Marios , Chang David , Olafsdottir Svannildur , Venckute Larsson Sigita , Tobiasson Magnus , Malcovati Luca , Woll Petter , Jacobsen Sten Eirik W. , Papaemmanuil Elli , Hellström-Lindberg Eva
Published: October 2023

MDSRS+ event free survival (EFS, A) and overall survival (OS, B) stratified by estimated MEP percentage and IPSS-mol risk category.
Supplementary Figure S2 from Neoantigen Targetability in Progressive Advanced Melanoma
Authors: van den Bulk Jitske , Verdegaal Els M.E. , van der Ploeg Manon , Visser Marten , Nunes Joana B. , de Ru Arnoud H. , Tjokrodirijo Rayman T.N. , Ijsselsteijn Marieke E. , Janssen Natasja I. , van der Breggen Ruud , de Bruin Linda , de Kok Pita , Janssen George M.C. , Ruano Dina , Kapiteijn Ellen H.W. , van Veelen Peter A. , de Miranda Noel F.C.C. , van der Burg Sjoerd H.
Published: October 2023

HLA class I and II expression on melanoma cell lines derived from early and later metastatic lesions.
Supplementary Information 1 from Urinary Tumor DNA MRD Analysis to Identify Responders to Neoadjuvant Immunotherapy in Muscle-invasive Bladder Cancer
Authors: Zhang Ruiyun , Zang Jingyu , Jin Di , Xie Feng , Shahatiaili Akezhouli , Wu Guangyu , Zhang Lu , Wang Lu , Zhang Yue , Zhao Zhixin , Du Pan , Jia Shidong , Fan Jinhai , Zhuang Guanglei , Chen Haige
Published: October 2023

Supplementary methods and clinical trial protocol
Data from Patient-Specific Targeting of the T-Cell Receptor Variable Region as a Therapeutic Strategy in Clonal T-Cell Diseases
Authors: Lucero Olivia M. , Lee Ji-Ann , Bowman Jenna , Johnson Kara , Sapparapu Gopal , Thomas John K. , Fan Guang , Chang Bill H. , Thiel-Klare Karina , Eide Christopher A. , Okada Craig , Palazzolo Mike , Lind Evan , Kosaka Yoko , Druker Brian J. , Lydon Nicholas , Bowers Peter M.
Published: October 2023

AbstractPurpose:
Targeted therapeutics are a goal of medicine. Methods for targeting T-cell lymphoma lack specificity for the malignant cell, leading to elimination of healthy cells. The T-cell receptor (TCR) is designed for antigen recognition. T-cell malignancies expand from a single clone that expresses one of 48 TCR variable beta (Vβ) genes, providing a distinct therapeutic target. We hypothesized that a mAb that is exclusive to a specific Vβ would eliminate the malignant clone while having minimal effects on healthy T cells.
Experimental Design:
We identified a patient with large granular T-cell leukemia and sequenced his circulating T-cell population, 95% of which expressed Vβ13.3. We developed a panel of anti-Vβ13.3 antibodies to test for binding and elimination of the malignant T-cell clone.
Results:
Therapeutic antibody candidates bound the malignant clone with high affinity. Antibodies killed engineered cell lines expressing the patient TCR Vβ13.3 by antibody-dependent cellular cytotoxicity and TCR-mediated activation-induced cell death, and exhibited specific killing of patient malignant T cells in combination with exogenous natural killer cells. EL4 cells expressing the patient's TCR Vβ13.3 were also killed by antibody administration in an in vivo murine model.
Conclusions:
This approach serves as an outline for development of therapeutics that can treat clonal T-cell–based malignancies and potentially other T-cell–mediated diseases.

See related commentary by Varma and Diefenbach, p. 4024
Dynamic Prognostic Score to Predict Survival in East Asian Elderly Populations with Dysphagia
Authors: Wang Jiao , Huang Shuying , Huang Lianghua , Tang Yunliang
Published: October 2023

Introduction: Dysphagia is a common disorder in older adults, leading to severe complications, including aspiration pneumonia, dehydration, malnutrition, weight loss, and even death. However, no prognostic model has been developed to predict the prognosis of older adults with dysphagia. Methods: Data from patients with dysphagia at a single center were retrospectively reviewed between 2014 and 2017. All data were obtained from the Dryad Digital Repository. The least absolute shrinkage and selection operator regression model was used to select potentially relevant features. Multiple Cox proportional hazard analysis was used to develop a model based on the training set. Results: The nomogram comprised age, sex, percutaneous endoscopic gastrostomy, chronic heart failure, total lymphocyte count, daily calorie intake, and severe pneumonia, which provided favorable calibration and discrimination in the training dataset, with AUCs for the 1-year, 2-year, and 3-year survival predictions of 0.833, 0.871, and 0.886, respectively. Furthermore, it showed acceptable discrimination in the validation cohort, with AUCs for the 1-year, 2-year, and 3-year survival predictions of 0.884, 0.834, and 0.782, respectively. Moreover, the decision curve analysis results revealed that the nomogram was clinically beneficial. Conclusion: A nomogram, combining seven demographic and clinical factors, provided an excellent preoperative prediction of survival probability in older individuals with dysphagia. This predictive model can be used as a reference to assist clinicians in making clinical decisions.
Current State and Future Prospects of Diagnosis and Management of TP53-Mutated Myeloid Neoplasms
Authors: Venugopal Sangeetha , Loghavi Sanam
Published: October 2023

TP53-mutated myeloid neoplasms including acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are notoriously treatment resistant with uniformly poor outcomes. TP53 status is an important prognostic indicator and early knowledge of the TP53 mutation/allelic state may assist in appropriate management including clinical trial enrollment for eligible patients. Thus far, no therapy has shown to demonstrate durable response or incremental survival benefit in TP53-mutated AML or MDS. Therefore, there is an urgent need for innovative therapies to improve the outcomes in this notoriously recalcitrant genomic subset. In this review, we dissect the biology, classification, prognosis, current treatment landscape, and the early phase evaluation of investigational agents in TP53-mutated AML and MDS.
Risk Assessment Score and Chi-Square Automatic Interaction Detection Algorithm for Hypertension Among Africans: Models From the SIREN Study
Authors: Asowata Osahon J. , Okekunle Akinkunmi Paul , Akpa Onoja M. , Fakunle Adekunle Gregory , Akinyemi Joshua O. , Komolafe Morenikeji Adeyoyin , Sarfo Fred Stephen , Akpalu Albert K. , Obiako Reginald , Wahab Kolawole W. , Osaigbovo(Osawaru) Godwin O. , Owolabi Lukman F. , Jenkins Carolyn M. , Calys-Tagoe Benedict Nii Laryea , Arulogun Oyedunni Sola , Ogbole Godwin I. , Ogah Okechukwu Samuel , Lambert Appiah T. , Ibinaiye Philip Oluleke , Adebayo Philip B. , Singh Arti , Adeniyi Sunday Adebori , Mensah Yaw B. , Laryea Ruth Y. , Balogun Olayemi , Chukwuonye Innocent Ijezie , Akinyemi Rufus O. , Ovbiagele Bruce , Owolabi Mayowa Ojo
Published: October 2023

BACKGROUND:

This study aimed to develop a risk-scoring model for hypertension among Africans.

METHODS:

In this study, 4413 stroke-free controls were used to develop the risk-scoring model for hypertension. Logistic regression models were applied to 13 risk factors. We randomly split the dataset into training and testing data at a ratio of 80:20. Constant and standardized weights were assigned to factors significantly associated with hypertension in the regression model to develop a probability risk score on a scale of 0 to 1 using a logistic regression model. The model accuracy was assessed to estimate the cutoff score for discriminating hypertensives.

RESULTS:

Mean age was 59.9±13.3 years, 56.0% were hypertensives, and 8 factors, including diabetes, age ≥65 years, higher waist circumference, (BMI) ≥30 kg/m
2
, lack of formal education, living in urban residence, family history of cardiovascular diseases, and dyslipidemia use were associated with hypertension. Cohen κ was maximal at ≥0.28, and a total probability risk score of ≥0.60 was adopted for both statistical weighting for risk quantification of hypertension in both datasets. The probability risk score presented a good performance—receiver operating characteristic: 64% (95% CI, 61.0–68.0), a sensitivity of 55.1%, specificity of 71.5%, positive predicted value of 70.9%, and negative predicted value of 55.8%, in the test dataset. Similarly, decision tree had a predictive accuracy of 67.7% (95% CI, 66.1–69.3) for the training set and 64.6% (95% CI, 61.0–68.0) for the testing dataset.

CONCLUSIONS:

The novel risk-scoring model discriminated hypertensives with good accuracy and will be helpful in the early identification of community-based Africans vulnerable to hypertension for its primary prevention.
A Novel Window Into Human Vascular Remodeling and Diagnosing Carotid Flow Impairment: The Petro‐Occipital Venous Plexus
Authors: Yang Wenjie , Sam Kevin , Qiao Ye , Huang Zhongqing , Steinman David A. , Wasserman Bruce A.
Published: October 2023

Background

Adaptive arterial remodeling caused by flow reduction from downstream stenosis has been demonstrated in animal studies. The authors sought to determine whether inward remodeling from downstream stenosis also occurs in humans and is detectable by ex vacuo expansion of the Rektorzik venous plexus (RVP) surrounding the petrous internal carotid artery.

Methods and Results

The authors analyzed 214 intracranial magnetic resonance imaging examinations that included contrast‐enhanced vessel wall imaging. RVP symmetry was qualitatively assessed on vessel wall imaging. RVP thickness (RVPT) was measured on the thicker side if asymmetric or randomly assigned side if symmetric. Maximum stenosis (M1 or intracranial internal carotid artery) was measured. Posterior communicating artery and A1 diameters (>1.0 mm and 1.5 mm, respectively) defined adequate collateral outflow when proximal to the stenosis. Seventy‐two patients had stenosis downstream from RVPT measurements. For those without adequate outflow (38 of 72), 95.0% with RVPT ≥1.0 mm had ≥50% stenosis compared with only 5.6% with RVPT <1.0 mm. For these 72 patients, higher RVPT (RVPT ≥1.0 mm versus <1.0 mm) and absent adequate outflow were associated with greater downstream stenosis (
P
<0.001) using multivariate regression. For patients with downstream stenosis without adequate outflow, asymmetric RVP thickening was associated with greater ipsilateral stenosis (
P
<0.001, all had ≥46% stenosis) when stenosis was unilateral and greater differences in stenosis between sides (
P
=0.005) when stenosis was bilateral.

Conclusions

Inward internal carotid artery remodeling measured by RVPT or RVP asymmetry occurs as downstream stenosis approaches 50%, unless flow is preserved through a sufficiently sized posterior communicating artery or A1, and may serve as a functional measure of substantial flow reduction from downstream stenosis.
Abstract P2008.1: Association Of Myocardial Stiffening With Impaired Relaxation In A Diabetic Murine Model Of Left Ventricular Diastolic Dysfunction
Authors: Mukherjee Tanmay , Neelakantan Sunder , Fugate Elizabeth , Mendiola Emilio , Burton Aaron , Lindquist Diana , Sadayappan Sakthivel , Avazmohammadi Reza
Published: October 2023

Introduction:
Left ventricular diastolic dysfunction (LVDD) is often manifested by impaired relaxation and myocardial stiffening in the left ventricle (LV). While impairments in the function of myofilament regulatory proteins are known to deteriorate LV relaxation, the effects of passive myocardial stiffening on the relaxation of active forces remain unknown.

Methods:
A diabetic murine model of LVDD (db/db, n=5) and wild-type mice (WT, n=5) were used to study the association between tissue-level passive stiffness and organ-level relaxation. Early transmitral flow velocity to mitral annular tissue velocity ratio (E/e’), measured by Doppler imaging, was used to assess LV relaxation. Cardiac magnetic resonance imaging was performed using a 7T Bruker scanner to estimate diastolic strains via image registration. Mechanical testing was performed on harvested LV free wall (LVFW) specimens to measure passive stiffness.

Results:
LVDD was confirmed by a high septal E/e’ ratio (Fig. 1A). The db/db mice presented an increase in passive LVFW stiffness measured as the tangent to the circumferential stress-strain curve at 30% strain (Fig. 1B). A positive correlation was observed between passive stiffness and E/e’ (Fig. 1C). End-diastolic strain calculations (Fig. 1D) corroborated LV filling impairment indicating significant reductions in circumferential LV strains (Fig. 1E).

Conclusion:
Passive stiffening may impair LV filling by not only restraining the passive stretch of the myocardium at diastole but also by decelerating the active relaxation. Further integrated in-vivo and ex-vivo studies of LVDD can deconvolute the “active” and “passive” causes of impaired relaxation.
Abstract P3189: Vcam-1-mediated Mitochondrial Biogenesis In Macrophages Exacerbates Inflammation And Atherosclerosis
Authors: Natarajan Niranjana , Florentin Jonathan , Johny Ebin , Ohayon Lee , Dutta Partha
Published: October 2023

Atherosclerotic cardiovascular disease is a leading cause of adult mortality worldwide. Macrophages play a key role in atherogenesis by sustaining the local inflammatory response, facilitating accumulation of immune cells in atheromas that contribute to plaque development. Mitochondrial metabolism plays a key role in governing inflammatory gene expression in macrophages. Yet, the role of mitochondrial biogenesis and mitochondrial DNA synthesis in regulating macrophage inflammation is not known. Vascular cell adhesion protein 1 (VCAM-1) expressed by endothelial cells mediates monocyte adhesion and extravasation in developing atherosclerotic plaques. We observed increased VCAM-1 expression in human and murine plaque macrophages. However, the function of this cell adhesion molecule expressed by macrophages is not known. Here, we evaluated if and how myeloid-VCAM-1 drive mitochondrial biogenesis, inflammation, and atherosclerosis pathology. Increased VCAM-1 expression in plaque macrophages correlated with oxidative DNA damage and mitochondrial volume. To understand the role of myeloid-Vcam1 in atherogenesis, we generated
Apoe
-/-
LyzM
cre/+
VCAM-1
fl/fl
mice. Consistently,
Apoe
-/-
mice lacking
Vcam1
in macrophages exhibited reduced atherosclerosis severity and inflammation. Vcam1-deficient macrophages exhibited decreased inflammation, oxidative phosphorylation, mitochondrial biogenesis, and mitochondrial DNA synthesis genes, including Cmpk2.
Cmpk2
deletion in macrophages after oxidized LDL treatment reduced inflammatory mediators that aggravate atherosclerosis. RNA sequencing analysis of
Vcam-1
-deficient plaque macrophages and analysis of macrophages lacking
Cmpk2
identified
Fcor
and
Lyz1
as the target genes of
Vcam1
and
Cmpk2
. Interestingly, atherosclerotic plaque macrophages deficient of
Sting
, which mediates inflammatory signaling in response to oxidized mitochondrial DNA, had increased levels of
Fcor
and
Lyz1
. Our data suggest that VCAM-1 in macrophages signals via CMPK2 and POLG to promote mitochondrial biogenesis, oxidation, and fragmentation, mediating atherogenesis.
SYRIAN IMMIGRATION EFFECT ON SOCIAL CAPITAL IN TURKEY: EMPIRICAL STUDY
Authors: SATICI Esra , KIRAL Halis
Published: October 2023

ABSTRACT

The aim of this study is to examine the impact of migration from Syria on Turkey's social capital. In this context, Turkey's social capital index produced at the provincial level and be considered as intervention year of 2012, the pre-intervention of 2007 and 2017 were evaluated after the intervention. One of the methods accepted in the impact analysis literature to examine the impact of immigrants who entered Turkey after the Syrian civil war on social capital; single group designs, comparative group designs, difference-in-difference method and trend score matching methods are applied and the results are interpreted. Accordingly, it was observed that Syrian migration did not have a positive or negative effect on the social capital index values evaluated within the scope of the criteria discussed in this study.
Ship Security Rules in China’s Maritime Traffic Safety Law: Increased Legal Flexibility in Maritime Security Measures and Potential Problems
Authors: Wang Qiuwen , Zhang Hu , Hu Chenghang
Published: October 2023

China recently amended its Maritime Traffic Safety Law (MTSL2021) and has introduced a series of stipulations concerning ship security. In these ship security rules, flexibility has been maintained in the decision to adopt maritime security measures in cases when ship operators and Chinese maritime authorities face maritime security threats. This research examines the ship security rules in MTSL2021, analyses how the rules’ ambiguities could provide flexibility as well as uncertainties in practical implementation, and explores how they may affect the law’s institutional coordination with other domestic laws and regulations as well as China’s maritime law enforcement coordination with other countries.
Repair Effect and Mechanism of Electrospinning Nanocomposite Material with Gelatin-Bletilla Striata Gum/Salvia Miltiorrhiza on Orthopedic Refractory Wounds
Authors: Hu Geliang , Deng Ming , Ma Yonggang , Ming Jianghua
Published: October 2023

For improving the wound healing probability of patients, this work discussed the application value and mechanism of nano-electrospinning (NES) composites combined with gelatin-Bletilla striata gum (BSG)/Salvia miltiorrhiza (SM) in the repair of orthopedic refractory wounds (ORWs). 40 patients with ORWs were included and randomly rolled into a control group (Ctrl group, treated with only NES composite) and an observation group (Obs group, NES+ gelatin-BSG/SM composite), with 20 cases in each. The expression levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and transforming growth factor beta 1 (TGF-β1) in the Obs group were higher than those in the Ctrl group (P<0.05). NES composite combined with gelatin-BSG/SM could promote the formation of tissues and blood vessels in ORWs by upregulate VEGF, b-FGF, and TGF-β1. Therefore, it was more conducive to the healing and repair of ORWs.
Resistance in Supervision: A Qualitative Study of Training Experiences Among Multiethnic Women
Authors: Diaz Emma B. , Goldbach Chloë , Hardy Crystal , Watson Tiara , Chambers-Baltz Stephanie , Knutson Douglas , Dykema Stephanie
Published: October 2023

Psychology trainees operate in high stress environments and supervisees with multiple marginalized identities, such as multiethnic women, must also navigate and/or resist discrimination. Resistance as a tool against oppression (positive resistance) is an emerging concept in psychology. Consensual qualitative research method was used to explore the ways multiethnic women engage in resistance during the supervision process. The central research question was, “How do multiethnic women engage in resistance to gender- and ethnicity-based inequities during supervision?” Participants ( N = 12) identified as multiethnic women who were in, or had recently graduated from, clinical or counseling psychology programs. Participants sat for a 60–90 minute interview. Analyses of the interview transcripts yielded the primary domain, Resistance, and three subdomains: Motivation for Resistance, Capability for Engagement, and Forms of Resistance. Implications for supervision with women are discussed, including ways that supervisors may encourage and respond to positive resistance in the training of diverse future psychologists.
Restorative Justice Treatment for Domestic Violence Crimes: A Qualitative Study
Authors: Barocas Briana , Avieli Hila , Mills Linda G.
Published: October 2023

Domestic Violence Intervention Programs have become a key component in addressing domestic violence (DV) crimes. Recent research suggests that combining standard intervention programs with other approaches can improve overall effectiveness. The aim of this study was to examine the experiences of individuals court-mandated to treatment who completed either a standard intervention program or a restorative justice (RJ)-based hybrid intervention program combining a standard treatment program with RJ elements and Circles of Peace. Multiple interviews were conducted with participants ( N = 14) who completed one of the two programs. Qualitative data analysis was performed. Four major themes emerged: Communication and understanding, Changes in the nature of the violence, Changes in self-perception, and Program content and atmosphere experiences. The findings suggest that the hybrid intervention program may have a positive influence on the way participants perceive treatment effectiveness. Participants’ experiences may serve as a framework for improving approaches to DV treatment.
Introduction to Special Issue: Geneses, organizations and transformations of psychiatric epidemiology
Authors: Delille Emmanuel , Lézé Samuel
Published: October 2023

Recent historiography has revealed a growing interest in the developments of psychiatric epidemiology. This volume aims to explicitly tackle the problem of transforming a diversity of knowledge into a structured scientific unit. Furthermore, it aims to answer this by bringing together historical studies that demonstrate how epistemic authority has led to the hierarchization of knowledge and the institutionalization of psychiatric epidemiology. Interdisciplinary research teams are traced back in history, and their organization is interrogated. Tracing the history of psychiatric epidemiology involves an exploration of disciplinary divisions of labour, such as how survey methods are based on theoretical frameworks, how research programmes are regulated with political and moral ideals, and how the wider public recognizes public health expertise.
Epithelioid Inflammatory Myofibroblastic Sarcoma With Poor Response to Crizotinib: A Case Report
Authors: Aminimoghaddam Soheila , Pourali Roghayeh
Published: October 2023

Introduction:

Epithelioid type inflammatory myofibroblastic sarcoma (EIMS) is a subtype of inflammatory myofibroblastic tumor (IMT). It consists of round or epithelioid cells, and almost all types of EIMS contain rearrangements of the anaplastic lymphoma kinase (ALK) gene.

Case presentation:

We describe a 20-year-old female presenting with abdominal pain and a rapidly growing intraabdominal mass who underwent surgical tumor resection. She was diagnosed with EIMS. ALK and ki-67 expressions were detected in immunohistochemistry assessment. She was started with Crizotinib 200 mg twice a day, and chemotherapy was also initiated due to the recurrence of the disease 4 months after the initial treatment. She was unresponsive to all the medical regimens and died in 8 months.

Conclusion:

Approach to patients with EIMS is really challenging in terms of both diagnosis and treatment. Patients with combined surgical and non-surgical treatment regimen were seen to have a more favorable outcome in some EIMS cases. Therefore, it is essential to implement a multidisciplinary approach to diagnose and treat patients suspicious of EIMS.
Vaccination frequency in people newly diagnosed with multiple sclerosis
Authors: Darvishi Sonia , Donnachie Ewan , Gasperi Christiane , Hapfelmeier Alexander , Hemmer Bernhard
Published: October 2023

Background:

Infections are discussed as risk factor for multiple sclerosis (MS) development and relapses. This may lead to decreased vaccination frequency in newly diagnosed patients.

Objective:

The aim of this study was to evaluate the relation of MS diagnosis to subsequent vaccination frequency.

Methods:

Based on German ambulatory claims data from 2005 to 2019, regression models were used to assess the relation of MS diagnosis ( n = 12,270) to vaccination. A cohort of patients with MS was compared to control cohorts with Crohn’s disease, psoriasis, and without these autoimmune diseases (total n = 198,126) in the 5 years after and before diagnosis.

Results:

Patients with MS were less likely to be vaccinated compared to persons without the autoimmune diseases 5 years after diagnosis (odds ratio = 0.91, p < 0.001). Exceptions were vaccinations against influenza (1.29, p < 0.001) and pneumococci (1.41, p < 0.001). Differences were strong but less pronounced after than before diagnosis ( p < 0.001). The likelihood of vaccination was also lower compared to patients with Crohn’s disease or psoriasis.

Conclusions:

Patients with MS were not adequately vaccinated despite guideline recommendations. Increasing awareness about the importance of vaccination is warranted to reduce the risk of infection, in particular, in patients with MS receiving immunotherapies.
Deconstructing verbal and nonverbal accommodation in Arabic cross-dialectal communication
Authors: Soulaimani Dris , Chakrani Brahim
Published: October 2023

Aims and objectives:

This study examines language accommodation in cross-dialectal encounters. It demonstrates how speakers of different Arabic varieties use (non)accommodation strategies that include both verbal and embodied actions.

Approach:

The study uses qualitative data from Arabic cross-dialectal communication. In the course of their interactions, participants draw on linguistic and nonlinguistic resources to achieve either convergent or divergent accommodation. Using the theoretical frameworks of discourse analysis (DA) and communication accommodation theory (CAT), the study investigates natural conversations for insight into qualities of Arabic cross-dialectal communication.

Data and analysis:

The data were collected in the United States. In this study, the participants originate from four major geographical areas in the Arab world, including the Maghreb, Egypt and Sudan, the Levant, and the Gulf.

Findings/conclusions:

The analysis demonstrates that successful accommodation requires a verbal and nonverbal collaborative construction of meaning to achieve co-participation. Participants linguistically converge while they display a shared Arab identity. The data also show that when a sense of shared Arabness is deemphasized and the positive social image to a group’s variety is violated, divergence as a nonaccommodative strategy is used.

Originality:

This is the first study that demonstrates how different modes of accommodation are expressed, not only through speech but also through embodied actions. The study shows that accommodation as a process is not complete at the verbal level; it must be orchestrated at multiple semiotic levels, including nonverbal ones.

Significance/implications:

Scholars have paid less attention to nonverbal accommodation. This study seeks to bridge this gap by analyzing both verbal and nonverbal accommodation, whether convergent or divergent, in Arabic cross-dialectal communication. It shows how speakers of different dialects use accommodation to signal intergroup relations and negotiate different social identities.