bluuebunny/crossref_metadata_2025 huggingface dataset:
Peningkatan Prestasi Belajar Matematika melalui Pembelajaran Discovery Learning dengan Adaptasi Lesson Study
Authors: Feriyanto Feriyanto , Abror Ahmad Nafi'ul , Dani Fernanda  , Ira Rismawati
Published: June 2023

Abstract: Improving Mathematics Learning Achievement through Learning Discovery Learning with Lesson Study Adaptation. The purpose of this study is to determine the application of the Lesson Study-Based Discovery Learning learning model to improve mathematics learning outcomes on the subject of Trigonometric Identity in class XI MIPA 4 semester 1 SMA Negeri 1 Gondang students for the 2022/2023 academic year. This research method uses a descriptive type of research using a qualitative approach. The subjects in this study were 34 students of class XI MIPA 4 SMAN 1 Gondang Mojokerto. The application of research is designed in accordance with the Lesson Study which consists of three stages, namely planning (Plan), implementation (Do), and evaluation (See). By using  the Discovery Learning Based Lesson Study learning model  , it can improve mathematics learning outcomes on the subject of Trigonometric Identity in class XI MIPA 4 semester 1 SMA Negeri 1 Gondang students for the 2022/2023 school year. This increase can be seen from the average score obtained by students, which is 70.60 on UH1, then increases to 81.78 on UH2.
Keywords:  mathematics learning, discovery learning, lesson study
Gaya Bahasa Penegasan dalam Novel Buku Besar Peminum Kopi Karya Andrea Hirata
Authors: Tudzahra Salsadila , Samsiarni Samsiarni , Septia Emil
Published: June 2023

Abstract: The Style of Affirmation Language in Andrea Hirata's Big Book of Coffee Drinkers. This study aimsto find out the style of affirmative language in the novel The Big Book of Coffee Drinkers by Andrea Hirata. The type of research used in this study uses qualitative research methods, emphasizes more on the ways of interpretation presented in the form of descriptions, qualitative research focuses more on scientific data, qualitative research methods to describe and explain the meaning in literary works, the novel Buku Besar Peminum Kopi by Andrea Hirata . The results of this study show that in this literary work the author uses the stylistic style of affirmation, namely, pleonasm, repetition and rhetoric, and climax.
Pengaruh Intensitas Penggunaan Gadget Terhadap Minat Belajar Siswa MI/SD
Authors: Fitriani Filly
Published: June 2023

Abstract : The Influence of Intensity Use of Gadgets on Learning Interests of Mi/SD Students. The purpose of this study was to determine the effect of the intensity of using gadgets on students' learning interest. This research is a research using a qualitative approach with descriptive methods on the intensity of gadget use as the independent variable and interest in learning as the dependent variable. The research data was obtained using literature study techniques. From various sources, there are negative and positive impacts that can be taken from using gadgets. From the analysis of the sources of using gadgets it is very influential for students' learning interest, if children make good use of gadgets to find information about lessons, students' interest in learning will increase because gadget features help students to learn, while the intensity of excessive use of gadgets will make students not interested. in learning because of addiction to gadgets.
Effect of Communication and Work Environment on Employee Performance
Authors: Ilham Rachmad , Budianto Shintya Nur Agustin
Published: June 2023

This study aims to find out: (1) to find out that communication has a partial effect on employee performance at PT Astra Sedaya Finance Gresik Branch (2) to find out that the work environment has a partial effect on employee performance at PT Astra Sedaya Finance Gresik Branch (3) to know communication and work environment influences simultaneously on the performance of employees of PT Astra Sedaya Finance Gresik Branch. In this study using primary data, while the research method involves one dependent variable (employee performance), and two independent variables (communication and work environment). The population used in this study were all PT Astra Sedaya Finance Gresik Branch employees, totaling 45 people. The sampling method was carried out using a non-probability sampling method. The technique used is saturated sampling technique. Data collection methods used in this study were questionnaires, documentation and interviews. The analytical method uses validity test, reliability test, multiple linear analysis, coefficient of determination, t test, F test. Conclusion of the study: communication has a partial effect on the performance of employees of PT Astra Sedaya Finance Gresik Branch, this is evidenced by the tcount (3.9437) > ttable (2.01808) and a significant level of 0.000 is smaller than alpha 0.05. The work environment has a partial effect on the performance of employees of PT Astra Sedaya Finance Gresik Branch, this is evidenced by the tcount (3.580) > ttable (2.01808) and a significant level of 0.000 is smaller than alpha 0.05. Communication and the environment simultaneously influence the performance of PT Astra Sedaya Finance Gresik Branch employees. This is evidenced by the value of Fcount (46.655) > Ftable (3.21) and a significant level of 0.000 is smaller than alpha 0.05.
INCONSTITUCIONALIDADE POR OMISSÃO NA PROMOÇÃO DA INTEGRAÇÃO DE AÇÕES DE SEGURANÇA PÚBLICA NAS FRONTEIRAS BRASILEIRAS
Authors: Coelho André Luiz Querino
Published: June 2023

O presente artigo versa sobre a transição do Estado Moderno ao Estado Pós-Moderno e a modificação da criminalidade em tais contextos. Apontando-se a inexistência, observado o dever constitucional de asseguramento do direito difuso à segurança pública, de ações articuladas que possam, efetivamente, prevenir e punir a criminalidade pós-moderna, especialmente a partir de ações nas fronteiras do Brasil.
ÁREA DE CONTROLE INTEGRADO SÃO BORJA/SANTO TOMÉ E A IMPORTÂNCIA DA PARCERIA PÚBLICO-PRIVADA
Authors: Rosas Della Flora Karla Lorena
Published: June 2023

Objetiva-se demonstrar a importância da Área de Controle Integrado do Centro Unificado de Fronteira São Borja/Santo Tomé por meio da parceria público-privado; concessão binacional; modelo de eficiência na gestão e prestação do serviço público; controles aduaneiros, migratórios, sanitários e fitossanitários, zoo-sanitários e de transporte totalmente integrados; facilitação do comércio internacional e imigração; segurança contra crimes transfronteiriços; desenvolvimento econômico, social e cultural da região fronteiriça; exemplo de boa prática para outras fronteiras brasileiras; fim da concessão; desinteresse brasileiro em renovar a concessão ou realizar nova licitação; governo argentino interesse na estatização do complexo aduaneiro; prejuízos econômicos e sociais para o Brasil e para o MERCOSUL; prorrogação precária da concessão por 365 dias (prorrogáveis por mais 365 dias); COMAB e órgãos técnicos responsáveis por elaborar nova proposta para o centro unificado de fronteira.
OPERAÇÕES COORDENADAS E COOPERAÇÃO INTERNACIONAL PARA O COMBATE AO TRÁFICO DE ARMAS - LEGISLAÇÃO, ESTRATÉGIAS E PERSPECTIVAS
Authors: Roos Faccin Nei Carlos
Published: June 2023

O combate ao tráfico de armas de fogo tem sido um dos grandes desafios às Instituições de Segurança Pública do Brasil, demandando expressivos esforços, na tentativa de evitar esse tipo de crime, bem como tirar de circulação as armas irregulares usadas para o cometimento dos mais diversos tipos de delitos, não só por parte de criminosos comuns, mas, principalmente, pelas grandes facções. Apesar da legislação brasileira ser bastante restritiva ao acesso às armas, as facções criminosas continuam se armando cada vez mais. Grande parte das armas utilizadas por essas quadrilhas vem de fora do país. Sabendo que os recursos tanto humanos quanto materiais são escassos, faz-se necessário que o poder público desenvolva estratégias eficazes para o enfrentamento a essa realidade, maximizando os resultados em prol da segurança pública.
ESTUDOS DE REPASSE E DE ALOCAÇÃO DE RECURSOS FINANCEIROS PARA UMA ESCOLA EM CASCAVEL
Authors: Almeida Carlos Alberto de , Faria Nilson Rosa
Published: June 2023

O estudo trata-se de resultados de uma investigação que trata do uso dos recursos financeiros públicos na Educação Básica Nacional, com base no Manual do Fundeb (Recurso Federal), e obtendo informações e orientações do Ministério Publico Nacional, do Tribunal de Contas do Estado do Paraná e do Conselho de Acompanhamento e Controle Social do Fundeb. A análise de dados foi desenvolvida em pesquisa nos sites do Tesouro Nacional, IBGE, Plano de Dados Aberto – PDA e do próprio Ministério da Educação e Cultura – MEC. O fluxo de informações e de dados dos recursos financeiros, disponibilizados à escola, é o objetivo principal deste trabalho. Dessa forma, podemos identificar e testar se os dados usados como parâmetros para a distribuição dos recursos financeiros são realistas, ou se as estimativas podem apresentar variações, e, como consequência, a escola necessita de novos recursos, e se há meios para que esses recursos se tornem realidade. A escola escolhida para a contemplação da investigação foi o Colégio Estadual Coronel Wilson Joffre, no município de Cascavel-PR. Esta pesquisa aponta a importância dos parâmetros que são utilizados na distribuição dos recursos financeiros para a educação básica, avaliando se esses parâmetros são efetivos.
MODAL RODOVIÁRIO PARANAENSE
Authors: Luz Fabio dos Santos Corrêa da , Faria Nilson Rosa
Published: June 2023

O presente trabalho visa a abordar aspectos do modal rodoviário paranaense, destacando os desafios do escoamento da produção. Nas pegadas desse processo, ocupa-se de estudar e refletir acerca da origem dos transportes e estradas na humanidade. Trata-se de compreender o esforço humano em se atingir alternativas para transportar suas mercadorias e a si próprio, indo desde a tração animal aos mais recentes automóveis e aeronaves. Igualmente, busca-se situar a economia do estado do Paraná, seu histórico, seus ciclos produtivos, anseios e necessidades, para, assim, analisar seu processo de consolidação rodoviária. O estado do Paraná, a despeito de seus desafios e problemas, tem-se mostrado um referencial para a República Federativa do Brasil. Isso porquanto se encontra na lista dos cinco maiores IDHs, dentre os estados-membros, e sua monocultura traz inúmeros benefícios ao mercado nacional. Isso tudo robustece a importância de se estudar e se aprimorar o transporte e modal rodoviário regional.
Factors Associated with Knowledge, Attitudes, and Practices about Tuberculosis in Peruvians
Authors: Loayza-Castro Joan A. , Vásquez-Romero Luisa Erika , Rubín-de-Celis Massa Verónica Eliana , Iturregui-Paucar Cori Raquel , Guillén-Ponce Norka Rocío , Indacochea-Cáceda Sonia , Torres-Malca Jenny Raquel
Published: June 2023

Objective: To determine the factors associated with knowledge, attitudes, and practices (KAPs) about tuberculosis (TB) in the Peruvian population.

Materials and Methods: A cross-sectional, analytical study was carried out by conducting a virtual survey. The instrument that was used consisted of 4 sections: sociodemographic variables (9 questions), knowledge (23 questions), attitudes (9 questions), and practices (8 questions) about tuberculosis. Univariate and bivariate analyses and the Poisson regression model with robust variance were used to obtain crude and adjusted prevalence ratios (PRa).

Results: The sample consisted of 1284 participants. Regarding knowledge, attitudes, and practices about TB, an insufficient level was found in 47.97%, 50.3%, and 54.36% of the cases, respectively. The variables that increased the probability of having sufficient knowledge were sex, grade, area, family history, and history of having TB. While only the area and both antecedents were for attitudes. Finally, the age, degree, and history of TB were for the practices.

Conclusion: There are insufficient KAPs in around half of the population studied. In addition, there are differences according to the epidemiological characteristics, such as sex, age, academic degree, area, and family history of TB and having had this disease. Therefore, the importance of research in this field should be emphasized in the face of a disease that is related to the differences in the levels of these variables between different strata of the general population.
Assessment of sustained attention in high-performance and attention deficit/hyperactivity disorder (ADHD) children with a vigilance task
Authors: Servera Mateu , Sáez Belén , Iglesias Rodríguez Tania
Published: June 2023

The main objective of this study was to compare children selected in a community setting with ADHD, high-performance, and normo-typical development on a sustained attention task. Three groups of children were selected: ADHD (n = 42), high-performance (n = 20), and normo- typical development (n = 28). A brief computerized vigilance task (CSAT-R) was applied to compare attentional capacity and reaction time. The participants were divided into those with “attentional dysfunction” and those with “normal attention” to analyze clinical validity. Children with high-performance were clearly differentiated from the other two groups, with large effect sizes. The differences between normo-typical and ADHD groups were only significant in the errors and in a nonparametric index of attentional capacity, but with small effect sizes. The CSAT-R showed good specificity and an acceptable positive predictive value, but low levels of sensitivity, and a poor negative predictive value. Therefore, sustained attention could be a prominent mechanism in children with high capacities. The CSAT-R (and probably most of attentional tasks) would be moderately useful in community settings for ADHD diagnosis, but not to rule it out.

El objetivo principal de este estudio fue comparar a niños seleccionados en un contexto comunitario con TDAH, alto rendimiento, y desarrollo normotípico, en una tarea de atención sostenida. Se seleccionaron tres grupos de niños: TDAH (n = 42), alto rendimiento (n = 20) y desarrollo normotípico (n = 28). Se aplicó una tarea breve de vigilancia computarizada (CSAT-R) para comparar la capacidad de atención y el tiempo de reacción. Para analizar la validez clínica, los participantes se dividieron en aquellos con "disfunción atencional" y aquellos con "atención normal”. Los niños con alto rendimiento se diferenciaron claramente de los otros dos grupos, con tamaños del efecto grandes. Las diferencias entre los grupos normotípico y TDAH solo fueron significativas en los errores y en un índice no paramétrico de capacidad de atención, pero con tamaños del efecto pequeños. La CSAT-R mostró una buena especificidad y un valor predictivo positivo aceptable, pero niveles bajos de sensibilidad y un pobre valor predictivo negativo. Por tanto, la atención sostenida podría ser un mecanismo destacado en niños con altas capacidades. La CSAT-R (y probablemente la mayoría de las tareas de atención) sería moderadamente útil en entornos comunitarios para el diagnóstico del TDAH, pero no para descartarlo.
Des jeunes « exceptionnel·le·s » : traduire les protagonistes autistes dans la littérature jeunesse
Authors: Coussy Audrey
Published: June 2023

Cet article s’intéresse à la représentation de l’autisme en littérature jeunesse et à la traduction de ces textes. Il s’agit dans un premier temps de retracer l’apparition des premiers personnages autistes dans les années 2000 et leur transformation en protagonistes accédant à une agentivité discursive. Ils figurent d’abord dans des récits policiers et nourrissent une certaine image archétypale de l’autisme, qui commencent à se nuancer et se diversifier durant la dernière décennie : des héroïnes émergent, ainsi que des autistes aux difficultés cognitives et relationnelles importantes, et les personnages autistiques ont aussi le droit à leurs histoires d’amour, loin du genre policier. Pour pouvoir rendre la poétique d’étrangéité présente dans ces oeuvres sources, les traducteurs et traductrices adoptent des stratégies traductives étrangéisantes qui défient la tendance historique à la domestication et au didactisme en traduction pour la jeunesse.
L’exception dans la traduction des Robâïât d’Edward Fitzgerald : la métrique, le rythme textuel et la rime
Authors: Nakhaei Bentolhoda
Published: June 2023

Robâïât est un recueil de quatrains persans rédigé par Omar Khayyâm au cours du douzième siècle en Iran. En 1859, le poète et traducteur britannique Edward FitzGerald a présenté la première traduction anglaise au lectorat anglais. En tant que poète, il a essayé de recréer le schéma rythmique du quatrain persan dans sa traduction. En d’autres termes, le traducteur victorien a essayé d’introduire la métrique persane du douzième siècle dans la littérature anglaise du dix-neuvième siècle. En s’appuyant sur les théories des traductologues et des linguistes tels que Derek Attridge, André Lefevere et Antoine Berman, cet article vise à examiner la façon dont FitzGerald a rendu le genre du quatrain persan et les quatrains de Khayyâm – qui ont une forme exceptionnelle – en anglais, tout en tenant compte des normes établies de la littérature anglaise. Il s’agit d’évaluer les changements opérés au niveau du sens et de la réception entre le texte persan et la traduction anglaise du chef-d’oeuvre de Khayyâm.
L’exception franco-canadienne dans deux romans ethnographiques québécois
Authors: Brun del Re Ariane
Published: June 2023

Cet article cherche à dégager les principales caractéristiques du roman ethnographique québécois explorant la francophonie canadienne en procédant à l’analyse comparative de La maudite Québécoise. Roman nationaliste (Tryptique, 2010) de Janis Locas et Yukonnaise (VLB Éditeur, 2012) de Mylène Gilbert-Dumas. Ces deux romans mettent en scène des protagonistes québécoises qui découvrent la francophonie manitobaine ou yukonnaise. Persuadées de tenir un sujet exceptionnel, elles s’improvisent ethnographes et décident de faire part de leur « découverte » dans un livre qui raconte les différences entre le Québec et la francophonie canadienne. Tout en s’interrogeant sur la perception que les Québécois et les Québécoises entretiennent des francophones en situation minoritaire et vice-versa, Locas et de Gilbert-Dumas proposent des pistes d’intégration à l’intention de leur public cible, le lectorat québécois.
De la injusticia epistémica al epistemicidio: un análisis comparado de los dos conceptos
Authors: Latova Santamaría Diana Rosa
Published: June 2023

El concepto de «injusticia epistémica» fue formalizado y teorizado por Miranda Fricker en 2007. No obstante, no fue la primera vez que se denunciaron y estudiaron fenómenos similares a los que aborda la autora. Problemáticas cercanas a la de la injusticia epistémica ya habían sido tratadas bajo denominaciones tales como «violencia epistémica» o «colonialismo intelectual». Una de ellas es el concepto de «epistemicidio», elaborado por Boaventura de Sousa Santos. Este trabajo trata de relacionar las teorías de la injusticia epistémica y del epistemicidio, intentando encontrar similitudes y diferencias relevantes, así como establecer posibles conexiones entre ellas.
Estado de Derecho y Democracia: equilibrio contramayoritario frente a efectos autoritarios de la polarización
Authors: Rivero Ortega Ricardo
Published: June 2023

La Democracia y el Estado de Derecho son principios constitucionales complementarios, no realizables por separado.   Una crítica constructiva sobre déficits es aceptable, pero la afirmación de su fracaso amenaza la legitimidad de instituciones imprescindibles para la convivencia social. Las aproximaciones académicas que enfrentan dialécticamente gobierno democrático y respeto de las normas favorecen reacciones autoritarias de signo extremista, en un marco de polarización social creciente y riesgo de quiebra de la Democracia. Por ello, los juristas debemos aportar soluciones, así como mostrar audacia y coraje en la defensa de los valores fundamentales. También debemos recordar que los equilibrios contramayoritarios compensan el riesgo de efectos autoritarios de la polarización.
La neurosis de Europa acerca del Estado comercial cerrado
Authors: Ehret Peter
Published: June 2023

La Unión Europea debe replantearse en su concepto de solidaridad que sostiene a sus múltiples sistemas de bienestar social. El problema de fondo es su relación con la identidad nacional. Este trabajo des-construye el argumento de una solidaridad social condicionada por un vínculo social primordial a través de una investigación filosófica que rastrea el devenir del fundamento normativo del Estado de bienestar. Apoyándose en GWF Hegel, Lorenz von Stein, Hermann Heller y Thomas Marshall, se demuestra que el discurso del Estado de bienestar encuentra su continuidad en una ciudadanía europea que desafía a los privilegios de la ciudadanía nacional.
González Ordovás, María José. Derechos versus democracia. Ironía de la globalización. Valencia: Tirant lo Blanch, 2022.
Authors: Pérez Jaraba Mª Dolores
Published: June 2023

Resensión de: González Ordovás, María José. Derechos versus democracia. Ironía de la globalización. Valencia: Tirant lo Blanch, 2022.
de Prada García, Aurelio. El proceso de Sócrates: del ‘nosotros’ al ‘yo’. Contra el prejuicio individualista no percibido. Madrid: Ápeiron, Faber & Sapiens, 2022.
Authors: Muñoz de Baena José Luis
Published: June 2023

Recensión de: de Prada García, Aurelio. El proceso de Sócrates: del ‘nosotros’ al ‘yo’. Contra el prejuicio individualista no percibido. Madrid: Ápeiron, Faber & Sapiens, 2022.
EFFECT OF SAW GINNING ON THE FIBRE QUALITY OF Bt AND NON-Bt COTTON
Authors: Daget Tekalgn Mamay , Tesema Getnet Belay
Published: June 2023

Bt cotton refers to a plant which has Bacillus thuringiensis (Bt) toxins in many of its cells. This naturally occurring soil bacterium will be used to reduce insect damage from bollworm, pink bollworm, and budworm. Therefore, farmers who are cultivating the Bt cotton variety will not be subjected to spray pesticides to control these worms. Whereas in this study, the non-Bt cotton (DP-90) refers to the commercially known variety which have no Bacillus thuringiensis (Bt) toxins in its cells. During the cultivation of non-Bt cotton varieties, the control of bollworms is done through the application of pesticides, which is a costly exercise in terms of cost of pesticides, spray equipment and labour. Along with the cost of cultivation, the best index to cotton quality is the performance of the fibres during spinning at the textile mill. In the present study the effect of saw ginning to the quality of both varieties was studied. The result could help the spinners to predict the preperformance of both varieties when subjected to the mechanical action of modern high rotating spinning machines parts. Ginning results a significant effect (at 0.05 level of significance) in all other measured fibre quality properties (upper half mean length, length uniformity index, short fibre content by number and by weight, level of neps, single fibre tenacity and elongation) of both Bt and non-Bt (DP-90) cotton varieties. The impact of ginning on the studied fibre quality properties was relatively severer on Bt cotton varieties than non-Bt (DP-90) varieties.
PASSIVE DAYTIME COOLING COTTON FABRIC WITH ADAPTIVE COMFORT FEATURES
Authors: Korkmaz Memiş Nazife , Kaplan Sibel
Published: June 2023

Passive daytime radiative cooling materials have attracted increasing attention due to their great potential for energy saving and the possibility to meet the need for smart clothes. However, the practical application of passive daytime cooling material in the textile industry is greatly affected by comfort components and also physical/mechanical properties that require optimization. Herein, it was aimed to develop a thermoregulating fabric using zinc oxide nanoparticles (ZnO), which provide dynamic and passive control of the infrared transmission, by adapting to the ambient temperature. For this aim, the cotton fabric was coated with a nanocomposite treatment composed of ZnO nanoparticles and temperature-responsive shape memory polyurethane (SMPU) matrix, obtaining strong scattering effects to control the wideband transmission of thermal radiation and also adaptive comfort features based on shape memory function. By reflecting sunlight of SMPU-ZnO nanocomposite coating, the cotton fabric can reach an average temperature drop of ∼ 2.2°C and 0.4°C compared to the raw ones under direct sunlight and also indoor at 40°C, respectively. Also, SMPU and SMPU-ZnO nanocomposite coated cotton fabric exhibited dynamic air and water vapour permeability hence adaptive comfort features. Owing to passive cooling and also adaptive comfort features besides the simple production process, this smart fabric is promising to be widely used in sports or protective clothing areas.
EMULSION ELECTROSPINNING OF PVA NANOFIBERS CONTAINING HYPERICUM PERFORATUM OIL
Authors: Pala Nursema , Aral Nebahat , Nergıs Banu
Published: June 2023

The aim of this study is to produce essential oil loaded nanofiber wound dressings from PVA, which is a biodegradable and biocompatible polymer, by emulsion electrospinning method. Hypericum Perforatum oil, known for its antibacterial, antioxidant and anti-inflammatory properties on skin disorders, was used and Kolliphor RH40 surfactant was added to emulsify oil in polymer solution. In order to examine the effect of surfactant amount on nanofiber morphology, surfactant was used at 2%, 4% and 6% (w/w) ratios. The effect of surfactant concentration on solution viscosity and fibre morphology were investigated by viscosity measurements and SEM analysis. To confirm the presence of Hypericum Perforatum oil in nanofibers structure FT-IR spectroscopy analysis were carried out. According to the results, the solution viscosity increased as the amount of surfactant increased. Additionally, it was observed that the average diameters of nanofibers, containing 2%, 4%, and 6% surfactant (w/w), increased compared to the pristine PVA nanofiber. In conclusion, the fiber morphology of Hypericum Perforatum oil-containing PVA nanofibers has been changed with the effect of surfactant.
DEVELOPMENT OF FLEXIBLE SENSOR STRUCTURES WITH ALERT FEATURE ON ROLLER BLIND SURFACE WORKING WITH SOLAR ENERGY
Authors: Hacıoğlu Berin , Yıldırım Murat , Alısoy Hafız
Published: June 2023

In the project, roller blinds with alarm sensors working with solar energy were developed. It is aimed to develop the alarm system, which is a security system product that has become the need of every house, on the curtain surface by designing flexible sensor structures. Lightweight fabric design, sensor design, system design and mobile application studies were carried out. User tests of the product with optimum values were carried out. As a result of the evaluations, it was seen that the lightweight fabric rate was 34% and the capacitive sensing distance of the selected pattern was 15 cm.
DESIGN AND DEVELOPMENT OF POLYLACTIDE BASED NANOFIBROUS pH INDICATOR
Authors: Palak Handan , Karagüzel Kayaoğlu Burçak
Published: June 2023

In this study, a colorimetric pH indicator was developed using nanofibrous mats of polylactide (PLA) including turmeric, a natural dye. Firstly, nanofibrous mats were produced by dissolving PLA at different concentrations in chloroform (CHL)/dimethylformamide (DMF) at various volume ratios, and morphological analysis was performed. Subsequently, turmeric was added at a concentration of 2% wt. to the polymer solution having a PLA concentration of 10% in 75/25 CHL/DMF, and nanofibrous pH indicators were produced. Then, pH indicators containing turmeric were immersed into pH buffer solutions (pH 1, 4, 7 and 10), and color variations were measured using a spectrophotometer. It was foreseen that the produced pH indicators have the potential to be used in intelligent food packaging applications.
INVESTIGATION OF TRIBOELECTRICITY ON TEXTILE STRUCTURES THROUGH A TEG WHICH COMBINES SLIDING AND VERTICAL MODE
Authors: Repoulıas Aristeidis , Ertekin Mustafa , Galata Sotiria F , Vassılıadıs Savvas , Marmaralı Arzu
Published: June 2023

The use of textile materials and structures to build textile-based TEGs is of particular interest as they can also offer unique textile properties. In this work, the initial goal is to present a prototype TEG measuring device and its experimental results for comparing the open circuit voltages coming from various pairs of knitted samples which may constitute part of a textile TEG. We focus on representing realistic testing conditions as on a wearable garment, by introducing a friction stage between the contact and separation stages which is applied under a lightweight load. Α second goal is to explore the possibilities of some environmentally friendly textile materials to provide electric energy, again under realistic conditions. From the carried tests, it was seen that even conventional natural knitted textiles structures like single jersey, without expensive and complex nano-treatments, can provide considerable voltages if they are part of a wearable garment. Moreover, it was found that even low friction under a weight load of 20grf is adequate to give the above results. The hereby presented measuring TEG device can be used in the comparison or improvement of textile or even non-textile based TEGs, in order to find optimal combinations of materials and designs to be used on clothing TEGs.
INVESTIGATION OF FLUID DISTRIBUTION AND REWET PERFORMANCE WITH THE USE OF DIFFERENT INNER LAYER DESIGN AND TOP SHEETS IN SANITARY NAPKINS
Authors: Culfa Gizem , Sarıoğlu Esin , Daşdemir Mehmet , Çelikten Ebru , Kaya Nacarkahya Tülin
Published: June 2023

Disposable hygienic products are classified as technical textile products and are used intensively in the field of medical textiles. As a hygienic textile product, a sanitary napkin consists of a top sheet, an inner layer (Acquisition Distribution Layer (ADL) and a core of Pulp/Superabsorbent mixture), and a back sheet. Nonwovens are commonly used in the production of these components. The most important factors to consider in new product design are rapid absorption of menstrual fluid, comfort, and also price. In this context, although there is a cost restriction on sanitary napkins, it is clear that the use of different new raw materials and methods will improve their performance characteristics. In this study, a new designed airlaid composite nonwoven combined with synthetic fiber and wood pulp was used as the inner layer of a sanitary napkin without the core. In addition, four different top sheet types were used in the sanitary napkin design. Liquid strike through time, rewet, and menstrual fluid diffusion of the samples were determined, to compare the performance of sanitary napkins with core and without the core. It was concluded that the inner layer design has a significant effect on the liquid strike through time and menstrual fluid diffusion properties. It has been revealed that the menstrual fluid diffusion value of airlaid composite nonwoven sanitary napkins is higher than the ADL+core inner layer. In addition, it was concluded that the top sheet type did not have a statistically significant effect on liquid strike through and rewet properties.
TIGER 17 PEPTIDE LOADED POLYCAPROLACTONE/CELLULOSE ACETATE ELECTROSPUN NANOFIBROUS MATS FOR APPLICATIONS IN CUTANEOUS WOUND DRESSINGS
Authors: Rıbeıro Ana R. M. , Teıxeıra Marta A. , Pereıra-lıma Sílvia M. M. A. , Costa Susana P. G. , Felgueıras Helena P.
Published: June 2023

A skin wound if not properly treated can result in a chronic wound susceptible to widespread infections, which can result in the patient's death. Currently, tissue engineering is described as an interdisciplinary field that combines principles of engineering, chemistry and biology to generate solutions that allow to repair, restore and/or improve the functions of injured tissues. In the same sense, the textile area addresses solutions based on polymeric fibers, produced from a wide range of polymers, which allow the generation of structures with a large surface area, porosity and mechanical resistance that can be used as bioactive dressings that promote a healing and efficient antimicrobial activity. This research work focused on the synthesis of Tiger 17, through microwave-assisted solid-phase synthesis methodologies, and Tiger 17 commercially obtained, respective structural characterization and evaluation of the antimicrobial capacity. Simultaneously, nanofibrous polymer matrices were produced using the electrospinning technique with the aim of immobilizing the developed biomolecule and thus creating potential vehicles for a local and sustainable antimicrobial action (controlled release). In order to verify its physical and chemical properties, advanced characterization techniques were used: proton nuclear magnetic resonance, high performance liquid chromatography, optical microscopy, scanning electron microscopy, fourier transform infrared spectroscopy–attenuated total reflectance, thermogravimetry, differential scanning calorimetry, contact angle and surface energy and determination of porosity and hydration.
Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
Authors: Duffet Loïc , Williams Elyse T , Gresch Andrea , Chen Simin , Bhat Musadiq A , Benke Dietmar , Hartrampf Nina , Patriarchi Tommaso
Published: June 2023

The glucagon-like peptide-1 receptor (GLP1R) is a broadly expressed target of peptide hormones with essential roles in energy and glucose homeostasis, as well as of the blockbuster weight-loss drugs semaglutide and liraglutide. Despite its large clinical relevance, tools to investigate the precise activation dynamics of this receptor with high spatiotemporal resolution are limited. Here, we introduce a novel genetically encoded sensor based on the engineering of a circularly permuted green fluorescent protein into the human GLP1R, named GLPLight1. We demonstrate that fluorescence signal from GLPLight1 accurately reports the expected receptor conformational activation in response to pharmacological ligands with high sensitivity (max ΔF/F0=528%) and temporal resolution (τON = 4.7 s). We further demonstrated that GLPLight1 shows comparable responses to glucagon-like peptide-1 (GLP-1) derivatives as observed for the native receptor. Using GLPLight1, we established an all-optical assay to characterize a novel photocaged GLP-1 derivative (photo-GLP1) and to demonstrate optical control of GLP1R activation. Thus, the new all-optical toolkit introduced here enhances our ability to study GLP1R activation with high spatiotemporal resolution.
A hybridizing-enhanced differential evolution for optimization
Authors: Ghasemi Mojtaba , Zare Mohsen , Trojovský Pavel , Zahedibialvaei Amir , Trojovská Eva
Published: June 2023

Differential evolution (DE) belongs to the most usable optimization algorithms, presented in many improved and modern versions in recent years. Generally, the low convergence rate is the main drawback of the DE algorithm. In this article, the gray wolf optimizer (GWO) is used to accelerate the convergence rate and the final optimal results of the DE algorithm. The new resulting algorithm is called Hunting Differential Evolution (HDE). The proposed HDE algorithm deploys the convergence speed of the GWO algorithm as well as the appropriate searching capability of the DE algorithm. Furthermore, by adjusting the crossover rate and mutation probability parameters, this algorithm can be adjusted to pay closer attention to the strengths of each of these two algorithms. The HDE/current-to-rand/1 performed the best on CEC-2019 functions compared to the other eight variants of HDE. HDE/current-to-best/1 is also chosen as having superior performance to other proposed HDE compared to seven improved algorithms on CEC-2014 functions, outperforming them in 15 test functions. Furthermore, jHDE performs well by improving in 17 functions, compared with jDE on these functions. The simulations indicate that the proposed HDE algorithm can provide reliable outcomes in finding the optimal solutions with a rapid convergence rate and avoiding the local minimum compared to the original DE algorithm.
Post COVID-19 Infection with Staphylococcus Aureus Bacteraemia: A Case Series
Authors: Karthik Meruva , Abburu Alekhya , Aftab Kainat
Published: June 2023

Staphylococcus aureus (S.aureus) is a leading bacterial pathogen, that causes deadly infections such as bacteraemia, Toxic Shock Syndrome (TSS) and endocarditis. It has been the main contributor to secondary bacterial infections during viral pandemics, greatly raising patient morbidity and fatality rates. It is unknown how this secondary bacteraemia would affect people who have Severe Acute Respiratory Distress Syndrome Coronavirus 2 (SARS-CoV2). Herein, the authors present a series of case studies of 8 patients, (4 males and 4 females) infected with Coronavirus Disease-2019 (COVID-19) at tertiary hospital, Hyderabad, India, who eventually developed S.aureus bacteraemia with widespread seeding of secondary infections including cellulitis and abscess formation. Adult patients aged 20-60 years of age who were infected with COVID-19 from June’2022-August’2022 and had positive bacterial cultures for S.aureus during admission were included in the study. A total of eight patients hospitalised for COVID-19 with secondary bacteraemia were identified. Of these patients admitted with severe limb infections, three patients expired after a week of ongoing treatment from their blood cultures. Multivariate analysis identified the onset of bacteraemia (>4 days from date of admission) and age as significant predictors of mortality in admitted patients. Systemic Inflammatory Response Syndrome (SIRS) scoring and blood cultures were used to identify the mortality risk with p-value=0.05 statistical significance. The patients were subsequently treated with antibiotics and given conservative management, some of the patients admitted to Intensive Care Unit (ICU) who had critical co-morbidities, expired within a week of ongoing treatment. The final outcome of the present case series was that bacteraemia caused by S.aureus is associated with a high mortality rate in COVID-19 patients. More research is needed to understand the relationship between COVID-19 and secondary S.aureus bacteraemia.
Influence of Biofertilizers and Phosphorus on Growth and Yield of Lentil (Lens culinaris Medik)
Authors: Kumar Mukesh , Singh Rajesh
Published: June 2023

The Experiment was conduct at Crop Research Farm, Department of Agronomy during Rabi season of 2022 on Lentil crop. The treatment consisted of three level of Biofertilizer Rhizobium, PSB and Rhizobium + PSB and three level of Phosphorus (30, 40 and 50 kg/ha) and control. The experiment was layout in Randomized Block Design (RBD) with 10 treatment and replicated thrice. The soil in the experimental area was sandy loam with pH (8.0), EC (0.56 dS/m), Organic Carbon (0.62%), available N (225 kg/ha), available P (38.2 kg/ha), and available K (240.7 kg/ha). The results revealed that the treatment-9 [Rhizobium + PSB + Phosphorus 50 kg/ha] produces higher plant height (36.60 cm), plant dry weight (6.64 g), maximum number of pods/plant (158.66), maximum number of seeds/pod (1.89), higher seed yield (2018.04 kg/ha) and stover yield (3530.60 kg/ha).
In silico Study of Ornithine Decarboxylase and HSP-90 Gene in the Anti-trypanosomal Activities of Annona muricata Annonaceae
Authors: Osho Innocent Bamidele , Adebayo Isaac Abayomi , Elekofehinti Olusola Olalekan , Durojaye Catherine Olusunmibola
Published: June 2023

Aims: Trypanosomiasis is one of the neglected tropical diseases of Sub-Saharan Africa caused by the numerous species and sub-species of the protozoan genus Trypanosoma. Soursop, also known as Annona muricata (Annonaceae), is a prevalent tropical plant species renowned for its numerous medicinal properties, including the treatment of protozoan infections. The fundamental mechanism of anti-trypanosomal effects of A. muricata was investigated using ornithine decarboxylase and HSP-90, which are validated potential drug targets.

Place and Duration of Study: Animal Parasitology and Microbiology Research Unit, Department of Animal Production and Health, Federal University of Technology, Akure, Nigeria, between March and October 2022.

Methodology: The interaction of compounds previously characterized from A. muricata was investigated against Ornithine decarboxylase and HSP-90 genes of Trypanosoma brucei brucei using Autodock Vina.

Results: Based on their binding affinity and binding free energy, eight compounds (rutin, kaempferol 3-O-rutinoside, annomuricinA, murihexocin B, muricatocin A, acetogenin, asimilobine, and gigantetrocin A) out of the 160 compounds screened were found to be effective against Trypanosoma brucei brucei. The hit molecules were further screened for ADME profiles. Acetogenin and asimilobine were considered the ideal drug candidates because they showed moderation for ADME properties and obeyed Lipinski’s rule of five.

Conclusion: This study confirmed the use of Annona muricata in the treatment of trypanosomosis and the probable compounds responsible for its antitrypanosomal effect are acetogenin and asimilobine which acts at the HSP-90 genes of the parasite Trypanosoma brucei brucei.
Applying Lessons From Major Public Health Accomplishments to Firearm Injuries in the US
Authors: Gonzalez-Guarda Rosa M.
Published: June 2023

This JAMA Forum discusses policies that reduce access to guns, reengineering to improve firearm safety, and hyperlocal community-led responses in marginalized communities.
Camrelizumab Plus Apatinib and Temozolomide as First-Line Treatment in Patients With Advanced Acral Melanoma
Authors: Mao Lili , Lian Bin , Li Caili , Bai Xue , Zhou Li , Cui Chuanliang , Chi Zhihong , Sheng Xinan , Wang Xuan , Tang Bixia , Yan Xieqiao , Li Siming , Kong Yan , Dai Jie , Wei Xiaoting , Li Juan , Duan Rong , Xu Huayan , Wu Xiaowen , Yang Yue , Cheng Fengzhuo , Zhang Cheng , Xia Fangzhou , Pang Zheng , Guo Jun , Si Lu
Published: June 2023

Importance

Acral melanoma, known for low tumor mutation burden, responds poorly to immunotherapy. A standard therapy is still lacking.

Objective

To investigate the activity and safety of camrelizumab (an anti–programmed cell death-1 antibody) plus apatinib (a vascular endothelial growth factor receptor 2 inhibitor) and temozolomide as first-line treatment in patients with advanced acral melanoma.

Design, Setting, and Participants

In this single-arm, single-center, phase 2 nonrandomized clinical trial, patients with treatment-naive unresectable stage III or IV acral melanoma were enrolled at Peking University Cancer Hospital and Institute between June 4, 2020, and August 24, 2021. The data cutoff date was April 10, 2022.

Interventions

Patients received 4-week cycles of intravenous camrelizumab, 200 mg, every 2 weeks; oral apatinib 250 mg, once daily; and intravenous temozolomide, 200 mg/m2, once daily on days 1 to 5 until disease progression or unacceptable toxic effects.

Main Outcomes and Measures

The primary end point was objective response rate as assessed by investigators according to the Response Evaluation Criteria In Solid Tumors (version 1.1). Secondary end points included progression-free survival, time to response, duration of response, disease control rate, overall survival, and safety.

Results

A total of 50 patients (32 men [64%]; median age, 57 years [IQR, 52-62 years]) were enrolled and received treatment. The median follow-up duration was 13.4 months (IQR, 9.6-16.2 months). The objective response rate was 64.0% (32 of 50; 95% CI, 49.2%-77.1%). The median time to response and duration of response were 2.7 months (IQR, 0.9-2.9 months) and 17.5 months (95% CI, 12.0 to not reached), respectively. The disease control rate was 88.0% (44 of 50; 95% CI, 75.7%-95.5%). The estimated median progression-free survival was 18.4 months (95% CI, 10.6 to not reached). The median overall survival was not reached. The most common grade 3 or 4 treatment-related adverse events were increased gamma-glutamyltransferase levels (15 [30%]), decreased neutrophil count (11 [22%]), increased conjugated bilirubin levels (10 [20%]), and increased aspartate aminotransferase levels (10 [20%]). No treatment-related deaths occurred.

Conclusions and Relevance

The findings of this nonrandomized clinical trial suggest that camrelizumab plus apatinib and temozolomide may be a potential first-line treatment option for patients with advanced acral melanoma, which warrants further validation in a randomized clinical trial.

Trial Registration

ClinicalTrials.gov Identifier: NCT04397770
Membrane association of the ATG8 conjugation machinery emerges as a key regulatory feature for autophagosome biogenesis
Authors: Tooze Sharon A. , Zhang Wenxin , Lazzeri Gianmarco , Gahlot Deepanshi , Thukral Lipi , Covino Roberto , Nishimura Taki
Published: June 2023

Autophagy is a highly conserved intracellular pathway that is essential for survival in all eukaryotes. In healthy cells, autophagy is used to remove damaged intracellular components, which can be as simple as unfolded proteins or as complex as whole mitochondria. Once the damaged component is captured, the autophagosome engulfs it and closes, isolating the content from the cytoplasm. The autophagosome then fuses with the late endosome and/or lysosome to deliver its content to the lysosome for degradation. Formation of the autophagosome, sequestration or capture of content, and closure all require the ATG proteins, which constitute the essential core autophagy protein machinery. This brief ‘nutshell’ will highlight recent data revealing the importance of small membrane‐associated domains in the ATG proteins. In particular, recent findings from two parallel studies reveal the unexpected key role of α‐helical structures in the ATG8 conjugation machinery and ATG8s. These studies illustrate how unique membrane association modules can control the formation of autophagosomes.
Improvement of deep learning prediction model in patient‐specific QA for VMAT with MLC leaf position map and patient's dose distribution
Authors: Tozuka Ryota , Kadoya Noriyuki , Tomori Seiji , Kimura Yuto , Kajikawa Tomohiro , Sugai Yuto , Xiao Yushan , Jingu Keiichi
Published: June 2023

Purpose

Deep learning‐based virtual patient‐specific quality assurance (QA) is a novel technique that enables patient QA without measurement. However, this method could be improved by further evaluating the optimal data to be used as input. Therefore, a deep learning‐based model that uses multileaf collimator (MLC) information per control point and dose distribution in patient's CT as inputs was developed.

Methods

Overall, 96 volumetric‐modulated arc therapy plans generated for prostate cancer treatment were used. We developed a model (Model 1) that can predict measurement‐based gamma passing rate (GPR) for a treatment plan using data stored as a map reflecting the MLC leaf position at each control point (MLPM) and data of the dose distribution in patient's CT as inputs. The evaluation of the model was based on the mean absolute error (MAE) and Pearson's correlation coefficient (r) between the measured and predicted GPR. For comparison, we also analyzed models trained with the dose distribution in patient's CT alone (Model 2) and with dose distributions recalculated on a virtual phantom CT (Model 3).

Results

At the 2%/2 mm criterion, MAE[%] and r for Model 1, Model 2, and Model 3 were 2.32% ± 0.43% and 0.54 ± 0.03, 2.70% ± 0.26%, and 0.32 ± 0.08, and 2.96% ± 0.23% and 0.24 ± 0.22, respectively; at the 3%/3 mm criterion, these values were 1.25% ± 0.05% and 0.36 ± 0.18, 1.57% ± 0.35% and 0.19 ± 0.20, and 1.39% ± 0.32% and 0.17 ± 0.22, respectively. This result showed that Model 1 exhibited the lowest MAE and highest r at both criteria of 2%/2 mm and 3%3 mm.

Conclusions

These findings showed that a model that combines the MLPM and dose distribution in patient's CT exhibited a better GPR prediction performance compared with the other two studied models.