bluuebunny/crossref_metadata_2025 huggingface dataset:
Uncharted Waters: Treating Trauma Symptoms in the Context of Early Psychosis
Authors: B. Folk Johanna , Tully Laura M. , Blacker Dawn M. , Liles Brandi D. , Bolden Khalima A. , Tryon Valerie , Botello Renata , Niendam Tara A.
Published: September 2019

Psychosis is conceptualized in a neurodevelopmental vulnerability-stress framework, and childhood trauma is one environmental factor that can lead to psychotic symptoms and the development of psychotic disorders. Higher rates of trauma are associated with higher psychosis risk and greater symptom frequency and severity, resulting in increased hospitalization rates and demand on outpatient primary care and mental health services. Despite an estimated 70% of individuals in the early stages of psychosis reporting a history of experiencing traumatic events, trauma effects (post-traumatic anxiety or depressive symptoms) are often overlooked in psychosis treatment and current interventions typically do not target commonly comorbid post-traumatic stress symptoms. We presented a protocol for Trauma-Integrated Cognitive Behavioral Therapy for Psychosis (TI-CBTp), an approach to treating post-traumatic stress symptoms in the context of early psychosis care. We provided a brief summary of TI-CBTp as implemented in the context of Coordinated Specialty Care and presented preliminary data supporting the use of TI-CBTp in early psychosis care. The preliminary results suggest that individuals with comorbid psychosis and post-traumatic stress symptoms can be appropriately and safely treated using TI-CBTp within Coordinated Specialty Care.
Application of Sentinel-2 Multispectral Data for Habitat Mapping of Pacific Islands: Palau Republic (Micronesia, Pacific Ocean)
Authors: Immordino Francesco , Barsanti Mattia , Candigliota Elena , Cocito Silvia , Delbono Ivana , Peirano Andrea
Published: September 2019

Sustainable and ecosystem-based marine spatial planning is a priority of Pacific Island countries basing their economy on marine resources. The urgency of management coral reef systems and associated coastal environments, threatened by the effects of climate change, require a detailed habitat mapping of the present status and a future monitoring of changes over time. Here, we present a remote sensing study using free available Sentinel-2 imagery for mapping at large scale the most sensible and high value habitats (corals, seagrasses, mangroves) of Palau Republic (Micronesia, Pacific Ocean), carried out without any sea truth validation. Remote sensing ‘supervised’ and ‘unsupervised’ classification methods applied to 2017 Sentinel-2 imagery with 10 m resolution together with comparisons with free ancillary data on web platform and available scientific literature were used to map mangrove, coral, and seagrass communities in the Palau Archipelago. This paper addresses the challenge of multispectral benthic mapping estimation using commercial software for preprocessing steps (ERDAS ATCOR) and for benthic classification (ENVI) on the base of satellite image analysis. The accuracy of the methods was tested comparing results with reference NOAA (National Oceanic and Atmospheric Administration, Silver Spring, MD, USA) habitat maps achieved through Ikonos and Quickbird imagery interpretation and sea-truth validations. Results showed how the proposed approach allowed an overall good classification of marine habitats, namely a good concordance of mangroves cover around Palau Archipelago with previous literature and a good identification of coastal habitats in two sites (barrier reef and coastal reef) with an accuracy of 39.8–56.8%, suitable for survey and monitoring of most sensible habitats in tropical remote islands.
The Origin and Early Evolution of Life: Prebiotic Chemistry
Authors: Fiore Michele
Published: September 2019

Microfossil evidence indicates that cellular life on Earth emerged during the Paleoarchean era be-tween 3 [...]
On the Influence of Capillary-Based Structural Health Monitoring on Fatigue Crack Initiation and Propagation in Straight Lugs
Authors: Moonens Marc , Wyart Eric , De Baere Dieter , Hinderdael Michaël , Ertveldt Julien , Jardon Zoé , Arroud Galid , Guillaume Patrick
Published: September 2019

This paper addresses the influence on the fatigue life induced by the implementation of a capillary-based structural health monitoring methodology, patented under the name eSHM. It consists in integrating structurally small and pressurized capillaries into the component, so that when a fatigue crack breaches the capillary network, it results in a leak flow to the open atmosphere and loss of pressure in the galleries which is detected by a pressure sensor. The novelty of the proposed system resides in the opportunity to locate the capillary according to the designer’s need, as one resorts to additive manufacturing for the part production. However, the presence of these galleries in highly stressed regions raises concerns about crack initiation at the capillary itself and accelerated fatigue crack growth. This paper aims at the quantification of the influence the eSHM has on the fatigue behavior of the component and the determination whether this influence is significant or not. To that purpose, numerical simulations on a straight lug component, using the finite elements and eXtended Finite Elements Methods (XFEM), are performed. Various capillary sizes and shapes are assessed, so as to enable a general conclusion on the impact of the eSHM methodology in straight lugs.
Surface Chirality in Rotational Magnetoelectrodeposition of Copper Films
Authors: Mogi Iwao , Morimoto Ryoichi , Aogaki Ryoichi , Takahashi Kohki
Published: September 2019

Chiral surface formation was investigated in rotational magnetoelectrodeposition (RMED) of copper films, where an electrochemical cell was rotated in magnetic fields. The RMED was conducted with clockwise or anticlockwise rotation in the magnetic fields parallel or antiparallel to the ionic currents. The rotational frequencies were 0.5–6 Hz, and the magnetic fields were 2–5 T. The chiral behaviors are divided into four types: type I has chirality depending on the magnetic field polarity, type II has chirality depending on the rotational direction, and type III has chirality depending on both directions. Type IV represents chiral symmetry breaking, where the RMED films exhibit only L activity in any magnetic field polarity and rotational direction.
Viscosity Methods and Split Common Fixed Point Problems for Demicontractive Mappings
Authors: Wang Yaqin , Fang Xiaoli , Kim Tae-Hwa
Published: September 2019

We, first, propose a new method for solving split common fixed point problems for demicontractive mappings in Hilbert spaces, and then establish the strong convergence of such an algorithm, which extends the Halpern type algorithm studied by Wang and Xu to a viscosity iteration. Above all, the step sizes in this algorithm are chosen without a priori knowledge of the operator norms.
Antioxidant Peptides from the Protein Hydrolysate of Spanish Mackerel (Scomberomorous niphonius) Muscle by in Vitro Gastrointestinal Digestion and Their In Vitro Activities
Authors: Zhao Guo-Xu , Yang Xiu-Rong , Wang Yu-Mei , Zhao Yu-Qin , Chi Chang-Feng , Wang Bin
Published: September 2019

For the full use of Spanish mackerel (Scomberomorous niphonius) muscle to produce antioxidant peptides, the proteins of Spanish mackerel muscle were separately hydrolyzed under five kinds of enzymes and in vitro gastrointestinal digestion, and antioxidant peptides were isolated from the protein hydrolysate using ultrafiltration and multiple chromatography methods. The results showed that the hydrolysate (SMPH) prepared using in vitro GI digestion showed the highest degree of hydrolysis (27.45 ± 1.76%) and DPPH radical scavenging activity (52.58 ± 2.68%) at the concentration of 10 mg protein/mL among the six protein hydrolysates, and 12 peptides (SMP-1 to SMP-12) were prepared from SMPH. Among them, SMP-3, SMP-7, SMP-10, and SMP-11 showed the higher DPPH radical scavenging activities and were identified as Pro-Glu-Leu-Asp-Trp (PELDW), Trp-Pro-Asp-His-Trp (WPDHW), and Phe-Gly-Tyr-Asp-Trp-Trp (FGYDWW), and Tyr-Leu-His-Phe-Trp (YLHFW), respectively. PELDW, WPDHW, FGYDWW, and YLHFW showed high scavenging activities on DPPH radical (EC50 1.53, 0.70, 0.53, and 0.97 mg/mL, respectively), hydroxyl radical (EC50 1.12, 0.38, 0.26, and 0.67 mg/mL, respectively), and superoxide anion radical (EC50 0.85, 0.49, 0.34, and 1.37 mg/mL, respectively). Moreover, PELDW, WPDHW, FGYDWW, and YLHFW could dose-dependently inhibit lipid peroxidation in the linoleic acid model system and protect plasmid DNA (pBR322DNA) against oxidative damage induced by H2O2 in the tested model systems. In addition, PELDW, WPDHW, FGYDWW, and YLHFW could retain their high activities when they were treated under a low temperature (<60 °C) and a moderate pH environment (pH 5–9). These present results indicate that the protein hydrolysate, fractions, and isolated peptides from Spanish mackerel muscle have strong antioxidant activity and might have the potential to be used in health food products.
Model-Based Analysis of Factors Affecting the Burden Layer Structure in the Blast Furnace Shaft
Authors: Li Haifeng , Saxén Henrik , Liu Weiqiang , Zou Zongshu , Shao Lei
Published: September 2019

The distribution of burden layers in an ironmaking blast furnace strongly influences the conditions in the upper part of the process. The bed permeability largely depends on the distribution of ore and coke in the lumpy zone, which affects the radial gas flow distribution in the shaft. Along with the continuous advancement of technology, more information about the internal conditions of the blast furnace can be obtained through advanced measurement equipment, including 2D profiles and 3D surface maps of the top burden surface. However, the change of layer structure along with the burden descent cannot be directly measured. A mathematical model predicting the burden distribution and the internal layer structure during the descending process is established in this paper. The accuracy of the burden distribution model is verified by a comparison with experimental results. A sensitivity study was undertaken to clarify the role of some factors on the arising layer distribution, including the descent-rate distribution, the initial burden surface profile, and the charging direction through the charging matrix. The findings can be used as a theoretical basis to guide plant operations for optimizing the charging.
Additive Manufacturing of Customized Metallic Orthopedic Implants: Materials, Structures, and Surface Modifications
Authors: Bai Long , Gong Cheng , Chen Xiaohong , Sun Yuanxi , Zhang Junfang , Cai Lecai , Zhu Shengyan , Xie Sheng Quan
Published: September 2019

Metals have been used for orthopedic implants for a long time due to their excellent mechanical properties. With the rapid development of additive manufacturing (AM) technology, studying customized implants with complex microstructures for patients has become a trend of various bone defect repair. A superior customized implant should have good biocompatibility and mechanical properties matching the defect bone. To meet the performance requirements of implants, this paper introduces the biomedical metallic materials currently applied to orthopedic implants from the design to manufacture, elaborates the structure design and surface modification of the orthopedic implant. By selecting the appropriate implant material and processing method, optimizing the implant structure and modifying the surface can ensure the performance requirements of the implant. Finally, this paper discusses the future development trend of the orthopedic implant.
Determination of Hydrogen Transport Behaviour in Boron-Manganese Steels Using Different Methods and Boundary Conditions
Authors: Kuhlmann Matthias , Mitzschke Niels , Jüttner Sven
Published: September 2019

Within the framework of the project "ELOBEV" (research of electrolytic coating systems for joining elements made of high-strength materials) funded by the Federal Ministry of Education and Research, a test methodology for the assessment of the danger of hydrogen-assisted and liquid metal-induced cracking for auxiliary joining elements is being developed. One working point of the project is the determination of the hydrogen transport behaviour in high-strength boron-manganese steels and their coating concepts. Permeation measurements under different boundary conditions are used to characterize the hydrogen transport in 22MnB5 and 37MnB4. The results are validated by thermal desorption analyses with a constant heating rate and an isothermal temperature control. Several methods for the determination of the diffusion velocity are investigated and the determined values are compared with each other.
Mode of Action of Dietary Dexamethasone May Not Be Dependent Upon Microbial Mechanisms in Broilers
Authors: Duff Audrey F. , Baxter Mikayla F. A. , Graham B. Danielle , Hargis Billy M. , Bielke Lisa R.
Published: September 2019

Dexamethasone (Dex), a synthetic glucocorticoid (GC), in feed has been shown to increase gut permeability via stress-mediated mechanisms, but the exact mode of action on gut barrier function is not fully understood. Stress has been reported to alter the profile and virulence of intestinal flora predisposing for opportunistic disease. This study aimed to evaluate the relationship between dietary Dex and recoverable intestinal microbial profile in broilers to better understand mode of action and refine future uses of the model. Three experiments were conducted that administered Dex-treated feed for one week in conjunction with the antibiotics BMD (bacitracin methylene disalicylate) or Baytril® (enrofloxacin) to evaluate if enteric microbial mechanisms were important in Dex-induced permeability. Serum fluorescein isothiocyanate-dextran (FITC-d) and bacterial translocation (BT) have been reported to increase after Dex treatment and were used to assess gut epithelial leakage. Shifts in bacterial profiles were also measured on selective agar. Combining Dex with BMD or Baytril resulted in increased (P < 0.05) serum FITC-d versus Dex-only. Additionally, Baytril did not reduce aerobic BT and bacterial profiles remained similar after Dex. These results suggest a minimal role of intestinal microbes in Dex-induced changes to intestinal barrier function.
Selective Flotation of Pyrite from Galena Using Chitosan with Different Molecular Weights
Authors: Zhang Wanjia , Sun Wei , Hu Yuehua , Cao Jian , Gao Zhiyong
Published: September 2019

Pyrite is a major gangue mineral associated with galena and other valuable minerals, and it is necessary to selectively remove pyrite to upgrade the lead concentrate by froth flotation. In this study, the flotation experiments of a single mineral and mixed minerals were performed using chitosan with different molecular weights (MW = 2−3, 3−6, 10 and 100 kDa) as a depressant, ethyl xanthate as a collector, and terpineol as a frother, in a bid to testify the separation of pyrite from galena. Flotation results showed that the selective flotation of pyrite from galena can be achieved under the preferred reagent scheme, i.e., 400 g/t chitosan (10 kDa), 1600 g/t ethyl xanthate, and 100 g/t terpineol, while chitosan with other molecular weights cannot. Furthermore, the results of the zeta potential and contact angle measurements revealed that chitosan (10 kDa) has a strong adsorption on galena yet a very weak adsorption on pyrite at the dosage of 400 g/t. This study showed that chitosan (10 kDa) has great potential in the industrial flotation separation of pyrite from lead concentrates.
Implications of Hf Isotopes for the Evolution of the Mantle Source of Magmas Associated with the Giant El Teniente Cu-Mo Megabreccia Deposit, Central Chile
Authors: Stern Charles , Pang Kwan-Nang , Lee Hao-Yang , Skewes M. , Arévalo Alejandra
Published: September 2019

We have determined the Hf isotopic compositions of 12 samples associated with the giant El Teniente Cu-Mo megabreccia deposit, central Chile. The samples range in age from ≥8.9 to 2.3 Ma and provide information about the temporal evolution of their magmatic sources from the Late Miocene to Pliocene. Together with previously published data, the new analysis indicates a temporal decrease of 10 εHf(t) units, from +11.6 down to +1.6, in the 12.7 m.y. from 15 to 2.3 Ma. These variations imply increasing incorporation of continental crust through time in the magmas that formed these rocks. The fact that the samples include mantle-derived olivine basalts and olivine lamprophyres suggests that these continental components were incorporated into their mantle source, and not by intra-crustal contamination (MASH). We attribute the increase, between the Middle Miocene and Pliocene, of crustal components in the subarc mantle source below El Teniente to be due to increased rates of subduction erosion and transport of crust into the mantle. The deposit formed above a large, long-lived, vertically zoned magma chamber that developed due to compressive deformation and persisted between ~7 to 4.6 Ma. Progressively more hydrous mantle-derived mafic magmas feed this chamber from below, providing heat, H2O, S and metals, but no unique “fertile” Cu-rich magma was involved in the formation of the deposit. As the volume of these mantle-derived magmas decreased from the Late Miocene into the Pliocene, the chamber crystallized and solidified, producing felsic plutons and large metal-rich magmatic-hydrothermal breccias that emplaced Cu and S into the older (≥8.9 Ma) mafic host rocks of this megabreccia deposit.
Molecular Mechanisms of Leonurus Cardiaca L. Extract Activity in Prevention of Staphylococcal Endocarditis—Study on in Vitro and ex Vivo Models
Authors: Sadowska Beata , Laskowski Dariusz , Bernat Przemysław , Micota Bartłomiej , Więckowska-Szakiel Marzena , Podsędek Anna , Różalska Barbara
Published: September 2019

Better understanding the mechanisms of Leonurus cardiaca L. extract (LCE) activity is necessary to prepare recommendations for the use of LCE-based herbal products for preventive/supportive purposes in case of infective endocarditis (IE) and other staphylococcal invasive infections. The aim of the study was to analyze molecular mechanisms of LCE effect on Staphylococcus aureus and blood platelets in the context of their interactions playing a pivotal role in such disorders. Using atomic force microscopy, we demonstrated that adhesion forces of S. aureus were markedly reduced after exposure to LCE at subinhibitory concentrations. The effect resulted from the impact of LCE on S. aureus cell morphology and the composition of phospholipids and fatty acids in bacterial membranes (assessed by HPLC), which modulated their stabilization, hydrophobicity, and charge. Moreover, using FACS we showed also that LCE significantly reduced GP IIb/IIIa expression on blood platelets, thus the disruption of platelet-fibrinogen interactions seems to explain antiplatelet effect of LCE. The obtained results prove the usefulness of LCE in the prevention of S. aureus adhesion, platelet activation, and vegetations development, however, also pointed out the necessity of excluding the cationic antibiotics from the treatment of S. aureus-associated IE and other invasive diseases, when motherwort herb is used simultaneously as an addition to the daily diet.
Anti-Metabolic Syndrome Effects of Fucoidan from Fucus vesiculosus via Reactive Oxygen Species-Mediated Regulation of JNK, Akt, and AMPK Signaling
Authors: Wang Xueliang , Shan Xindi , Dun Yunlou , Cai Chao , Hao Jiejie , Li Guoyun , Cui Kaiyun , Yu Guangli
Published: September 2019

Recent studies have reported that dietary fiber improved metabolic syndrome (MetS). However, the effects of fucoidans on MetS were still not clear. In this study, we evaluated the activity of fucoidan from Fucus vesiculosus (FvF) on attenuating MetS and first elucidated the underlying mechanism. In vitro, FvF treatment remarkably lowered the level of reactive oxygen species (ROS) compared with the sodium palmitate (PA)-induced insulin resistance (IR) group. The phosphorylation level of c-Jun N-terminal kinase (JNK) was significantly decreased, while phosphorylation of protein kinase B (pAkt) level increased, compared with that of the HepG2 cells treated with PA. Thus, FvF increased glucose consumption and relieved IR via ROS-mediated JNK and Akt signaling pathways. In addition, these changes were accompanied by the activation of adenosine 5′-monophosphate-ativated protein kinase (AMPK) and its downstream targets (e.g., HMG-CoA reductase (HMGCR), acetyl-CoA carboxylase (ACC), and sterol-regulatory element-binding protein-1c (SREBP-1C)), which improved lipid metabolism in IR HepG2 cells. In vivo, FvF improved hyperglycemia and decreased serum insulin level in mice with MetS. Furthermore, we evaluated the inhibition of glucose transport by in vitro (Caco-2 monolayer model), semi-in vivo (everted gut sac model) and oral glucose tolerance test (OGTT), which indicated that FvF could significantly reduce the absorption of glucose into the blood stream, thus it could improve blood-glucose levels and IR in mice with MetS. Moreover, FvF decreased serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) levels and liver lipid accumulation, while increased the serum high density lipoprotein cholesterol (HDL-C) level in mice with MetS. Therefore, FvF could be considered as a potential candidate for the treatment of MetS by alleviating IR, inhibiting glucose transportation, and regulating lipid metabolism.
Black Sorghum Phenolic Extract Regulates Expression of Genes Associated with Oxidative Stress and Inflammation in Human Endothelial Cells
Authors: Francis Nidhish , Rao Shiwangini , Blanchard Christopher , Santhakumar Abishek
Published: September 2019

Oxidative stress is one of the primary factors leading to endothelial dysfunction, a major underlying cause of vascular disorders. This study aims to understand the key signalling pathways regulated by sorghum (Shawaya short black 1 variety; characterised to be very high in its antioxidant activity) under oxidative stress in endothelial cells. Human umbilical vein endothelial cells (HUVECs) were pre-treated with non-cytotoxic concentrations of phenolic-rich black sorghum extract (BSE) prior to induction of oxidative stress using hydrogen peroxide (H2O2). Treatment with BSE upregulated the expression of heme oxygenase 1 (HO1) and endothelial nitric oxide synthase (eNOS) and downregulated the levels of NADPH oxidase 4 (NOX4). BSE treatment significantly reduced the expression of pro-inflammatory mediators such as monocyte chemoattractant protein 1 (MCP1) and intracellular adhesion molecule 1 (ICAM1). Results from this study suggest that phenolic-rich BSE may reduce oxidative stress by regulating pro- and antioxidant signalling pathways and the expression of inflammatory mediators linked to endothelial dysfunction under oxidative stress.
Coordination Behavior of 1,4-Disubstituted Cyclen Endowed with Phosphonate, Phosphonate Monoethylester, and H-Phosphinate Pendant Arms
Authors: Bárta Jiří , Hermann Petr , Kotek Jan
Published: September 2019

Three 1,4,7,10-tetraazacyclododecane-based ligands disubstituted in 1,4-positions with phosphonic acid, phosphonate monoethyl-ester, and H-phosphinic acid pendant arms, 1,4-H4do2p, 1,4-H2do2pOEt, and 1,4-H2Bn2do2pH, were synthesized and their coordination to selected metal ions, Mg(II), Ca(II), Mn(II), Zn(II), Cu(II), Eu(III), Gd(III), and Tb(III), was investigated. The solid-state structure of the phosphonate ligand, 1,4-H4do2p, was determined by single-crystal X-ray diffraction. Protonation constants of the ligands and stability constants of their complexes were obtained by potentiometry, and their values are comparable to those of previously studied analogous 1,7-disubstitued cyclen derivatives. The Gd(III) complex of 1,4-H4do2p is ~1 order of magnitude more stable than the Gd(III) complex of the 1,7-analogue, probably due to the disubstituted ethylenediamine-like structural motif in 1,4-H4do2p enabling more efficient wrapping of the metal ion. Stability of Gd(III)–1,4-H2do2pOEt and Gd(III)–H2Bn2do2pH complexes is low and the constants cannot be determined due to precipitation of the metal hydroxide. Protonations of the Cu(II), Zn(II), and Gd(III) complexes probably takes place on the coordinated phosphonate groups. Complexes of Mn(II) and alkali-earth metal ions are significantly less stable and are not formed in acidic solutions. Potential presence of water molecule(s) in the coordination spheres of the Mn(II) and Ln(III) complexes was studied by variable-temperature NMR experiments. The Mn(II) complexes of the ligands are not hydrated. The Gd(III)–1,4-H4do2p complex undergoes hydration equilibrium between mono- and bis-hydrated species. Presence of two-species equilibrium was confirmed by UV-Vis spectroscopy of the Eu(III)–1,4-H4do2p complex and hydration states were also determined by luminescence measurements of the Eu(III)/Tb(III)–1,4-H4do2p complexes.
Porphyrin Supramolecular Arrays Formed by Weakly Interacting Meso-Functional Groups on Au(111)
Authors: Sánchez-Muñoz Esteban , Gárate-Morales José L. , Sandoval-Lira Jacinto , Hernández-Pérez Julio M. , Aguilar-Sánchez Rocío
Published: September 2019

The formation of a binary porphyrinic self-assembled system between meso-tetrakis(4-carboxyphenyl) porphyrin (TCPP) and meso-tetrakis(4-dimethyl amino) porphyrin (TDAP) was easily designed through non-covalent interactions in solution and adsorbed on a gold substrate. It was found that non-covalent interactions and geometrical conformations between porphyrins allow their self-assembly into a well-defined arrangement, which was confirmed by UV-Vis spectroscopy, electrochemistry, atomic force microscopy and density functional theory (DFT) studies.
Theoretical Studies of IR and NMR Spectral Changes Induced by Sigma-Hole Hydrogen, Halogen, Chalcogen, Pnicogen, and Tetrel Bonds in a Model Protein Environment
Authors: Michalczyk Mariusz , Zierkiewicz Wiktor , Wysokiński Rafał , Scheiner Steve
Published: September 2019

Various types of σ-hole bond complexes were formed with FX, HFY, H2FZ, and H3FT (X = Cl, Br, I; Y = S, Se, Te; Z = P, As, Sb; T = Si, Ge, Sn) as Lewis acid. In order to examine their interactions with a protein, N-methylacetamide (NMA), a model of the peptide linkage was used as the base. These noncovalent bonds were compared by computational means with H-bonds formed by NMA with XH molecules (X = F, Cl, Br, I). In all cases, the A–F bond, which lies opposite the base and is responsible for the σ-hole on the A atom (A refers to the bridging atom), elongates and its stretching frequency undergoes a shift to the red with a band intensification, much as what occurs for the X–H bond in a H-bond (HB). Unlike the NMR shielding decrease seen in the bridging proton of a H-bond, the shielding of the bridging A atom is increased. The spectroscopic changes within NMA are similar for H-bonds and the other noncovalent bonds. The C=O bond of the amide is lengthened and its stretching frequency red-shifted and intensified. The amide II band shifts to higher frequency and undergoes a small band weakening. The NMR shielding of the O atom directly involved in the bond rises, whereas the C and N atoms both undergo a shielding decrease. The frequency shifts of the amide I and II bands of the base as well as the shielding changes of the three pertinent NMA atoms correlate well with the strength of the noncovalent bond.
High-Power Large-Energy Raman Soliton Generations Within a Mode-Locked Yb-Doped Fiber Laser Based on High-Damage-Threshold CVD-MoS2 as Modulator
Authors: Ma Pengfei , Lin Wei , Zhang Huanian , Xu Shanhui , Yang Zhongmin
Published: September 2019

In our work, based on a high-damage-threshold MoS2 saturable absorber (SA), high-power intra-cavity Raman solitons within a passively mode-locked Yb-doped fiber laser were demonstrated successfully for the first time. The damage threshold of the MoS2 SA was as high as ~0.48 J/cm2. By adjusting the polarization states, stable single- or dual-pulse Raman soliton operations were obtained. The maximum average output power for single-pulse and dual-pulse Raman soliton operations was 80.11 and 89.33 mW, respectively. Our experiment results show significant enhancement in comparison with previous works, which provides fundamental guidance for future designs of high-power, large-energy, intra-cavity Raman soliton generations based on two-dimensional materials as SAs.
Development and Applications of MOFs Derivative One-Dimensional Nanofibers via Electrospinning: A Mini-Review
Authors: Liu Mingming , Cai Ning , Chan Vincent , Yu Faquan
Published: September 2019

Metal organic frameworks (MOFs) have been exploited for various applications in science and engineering due to the possibility of forming different mesoscopic frameworks and pore structures. To date, further development of MOFs for practical applications in areas such as energy storage and conversion have encountered tremendous challenge owing to the unitary porous structure (almost filled entirely with micropores) and conventional morphology (e.g., sphere, polyhedron, and rod shape). More recently, one-dimensional (1D) MOFs/nanofibers composites emerged as a new molecular system with highly engineered novel structures for tailored applications. In this mini-review, the recent progress in the development of MOFs-based 1D nanofibers via electrospinning will be elaborated. In particular, the promising applications and underlying molecular mechanism of electrospun MOF-derived carbon nanofibers are primarily focused and analyzed here. This review is instrumental in providing certain guiding principles for the preparation and structural analysis of MOFs/electrospun nanofibers (M-NFs) composites and electrospun MOF-derived nanomaterials.
Highly Dispersed Ag2S Nanoparticles: In Situ Synthesis, Size Control, and Modification to Mechanical and Tribological Properties towards Nanocomposite Coatings
Authors: Ma Yanjun , Zhao Zhicheng , Xian Yanbo , Wan Hongqi , Ye Yinping , Chen Lei , Zhou Huidi , Chen Jianmin
Published: September 2019

A facile in situ synthesis approach and a size control strategy were established to obtain Ag2S nanoparticles in polyimide (PI) composite coatings. Such Ag2S nanoparticles in the composite coatings were characterized, and the effects of the as-obtained Ag2S nanoparticles of different sizes on the mechanical and tribological properties of the nanocomposite coatings were investigated. Results indicate that the in situ synthesized Ag2S nanoparticles exhibited good dispersibility and bimodal and multimodal size distribution in the nanocomposite coatings. The size of the Ag2S nanoparticles can be effectively controlled by adjusting the substituent alkyl chain length of single-source precursor, and these Ag2S nanoparticles exhibited superior improvement to mechanical and tribological properties of the nanocomposite coatings. More importantly, the Ag2S nanoparticles with the proper grain size and bimodal size distribution provided the optimal mechanical and tribological properties for the nanocomposite coatings, and the excellent tribological properties were attributed to their outstanding mechanical properties and strong ability to form a homogenous and stable protective tribofilm.
Comparing the Effect of Folic Acid and Pentoxifylline on Delaying Dialysis Initiation in Patients with Advanced Chronic Kidney Disease
Authors: Yang Hsun , Juang Shiun-Yang , Liao Kuan-Fu , Chen Yi-Hsin
Published: September 2019

Background: We hypothesized that the nutrient loss and chronic inflammation status may stimulate progression in advanced chronic kidney disease. Therefore, we aimed to generate a study to state the influence of combined nutritional and anti-inflammatory interventions. Methods: The registry from the National Health Insurance Research Database in Taiwan was searched for 20–90 years individuals who had certified end-stage renal disease. From January 2005 through December 2010, the diagnosis code ICD-9 585 (chronic kidney disease, CKD) plus erythropoiesis-stimulating agent (ESA) use was defined as entering advanced chronic kidney disease. The ESA starting date was defined as the first index date, whereas the initiation day of maintenance dialysis was defined as the second index date. The duration between the index dates was analyzed in different medical treatments. Results: There were 10,954 patients analyzed. The combination therapy resulted in the longest duration (n = 2184, median 145 days, p < 0.001) before the dialysis initiation compared with folic acid (n = 5073, median 111 days), pentoxifylline (n = 1119, median 102 days, p = 0.654), and no drug group (control, n = 2578, median 89 days, p < 0.001). Lacking eGFR data and the retrospective nature are important limitations. Conclusions: In patients with advanced CKD on the ESA treatment, the combination of folic acid and pentoxifylline was associated with delayed initiation of hemodialysis.
Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly
Authors: An Ran , Wilms Ellen , Smolinska Agnieszka , Hermes Gerben D.A. , Masclee Ad A.M. , de Vos Paul , Schols Henk A. , van Schooten Frederik J. , Smidt Hauke , Jonkers Daisy M.A.E. , Zoetendal Erwin G. , Troost Freddy J.
Published: September 2019

Aging is accompanied with increased frailty and comorbidities, which is potentially associated with microbiome perturbations. Dietary fibers could contribute to healthy aging by beneficially impacting gut microbiota and metabolite profiles. We aimed to compare young adults with elderly and investigate the effect of pectin supplementation on fecal microbiota composition, short chain fatty acids (SCFAs), and exhaled volatile organic compounds (VOCs) while using a randomized, double-blind, placebo-controlled parallel design. Fifty-two young adults and 48 elderly consumed 15 g/day sugar beet pectin or maltodextrin for four weeks. Fecal and exhaled breath samples were collected before and after the intervention period. Fecal samples were used for microbiota profiling by 16S rRNA gene amplicon sequencing, and for analysis of SCFAs by gas chromatography (GC). Breath was used for VOC analysis by GC-tof-MS. Young adults and elderly showed similar fecal SCFA and exhaled VOC profiles. Additionally, fecal microbiota profiles were similar, with five genera significantly different in relative abundance. Pectin supplementation did not significantly alter fecal microbiota, SCFA or exhaled VOC profiles in elderly or young adults. In conclusion, aside from some minor differences in microbial composition, healthy elderly and young adults showed comparable fecal microbiota composition and activity, which were not altered by pectin supplementation.
Diet Diversity and Micronutrient Adequacy among Filipino School-Age Children
Authors: Mak Tsz-Ning , Angeles-Agdeppa Imelda , Lenighan Yvonne M. , Capanzana Mario V. , Montoliu Ivan
Published: September 2019

Previous studies have shown that the dietary diversity of young Filipino children to be limited and that the prevalence of nutrient inadequacies is high. This study extends the current knowledge to examine the relationship between diet diversity and the probability of adequacy of micronutrients among Filipino schoolchildren (aged 6 to 12 years), by the wealth status and dwelling location. The dietary intake data were collected using a single 24-h recall from 6460 children in the Filipino National Nutrition Survey 2013. The diet diversity score (DDS) and the probability of adequacies (PA) of 11 micronutrients were calculated, and further stratified by socio-economic status (SES) and dwelling location. The diet diversity was generally low (mean DDS = 4 out of 9). Children from the lowest SES, and living in rural areas, tended to have a lower DDS. Children with a DDS of 1 were likely to be inadequate in all 11 micronutrients. The higher DDS (≥6) was associated with higher PAs for the B vitamins but not for calcium, folate, iron, vitamin A and to large extent, vitamin C. This suggests that it was difficult for this population to achieve adequacy in these 5 micronutrients. More rigorous research on the topic is needed. Better access to nutrient-rich or fortified staple foods, in tandem with increased education on the importance of dietary diversity, are potential strategies to support children in achieving adequate micronutrient intakes.
Relationships of Trait Anxiety and Loss of Control Eating with Serum Leptin Concentrations among Youth
Authors: Byrne Meghan E. , Tanofsky-Kraff Marian , Jaramillo Manuela , Shank Lisa M. , LeMay-Russell Sarah , Rubin Sarah G. , Ramirez Sophie , Altman Deborah R. , Schvey Natasha A. , Brady Sheila M. , Shomaker Lauren B. , Courville Amber B. , Yang Shanna B. , Kozlosky Merel , Broadney Miranda M. , Yanovski Susan Z. , Yanovski Jack A.
Published: September 2019

Loss of control (LOC) eating in youth is associated with elevated fasting serum leptin, even after accounting for adiposity. Anxiety is closely linked to, and may exacerbate, LOC eating. Yet, it remains unclear how anxiety relates to leptin, or if the relationship is moderated by the presence of LOC eating. We examined whether self-reported trait anxiety interacted with LOC eating in relation to leptin in a convenience sample of youths (n = 592; 13.1 ± 2.7 years; body mass index z-score (BMIz) = 0.9 ± 1.1; 61.8% girls; 53.5% non-Hispanic White; 36.6% with LOC eating). LOC eating was assessed by interview. Leptin was measured after an overnight fast. Exploratory analyses were conducted to examine anxiety and LOC eating in relation to laboratory intake patterns in three sub-samples. In a generalized linear model adjusting for relevant covariates, anxiety significantly interacted with LOC eating in relation to leptin (p = 0.02), such that greater trait anxiety related to higher concentrations of leptin only among youth with LOC eating. Trait anxiety was not significantly related to fasting serum leptin independently in a generalized linear model adjusting for age, race, height, sex, study type, and fat mass (kg). Exploratory mechanistic analyses of food intake patterns did not identify consistent results for participants with both anxiety and LOC eating. Among youth with LOC eating, anxiety may be associated with higher serum leptin. Prospective data are required to elucidate the directionality and mechanisms of these relationships.
Non-Nutritive (Artificial) Sweetener Knowledge among University Students
Authors: Wilson Ted , Murray Breanna , Price Tamara , Atherton Denzel , Hooks Tisha
Published: September 2019

This study determined non-nutritive sweetener (NNS; artificial sweetener) depth of knowledge among university health and science students. An online survey was delivered to 1248 science students and completed by 493 respondents (19.0 ± 2.2 years old), evaluating ability to provide an NNS description/definition, examples of NNS from memory, and evaluate NNS word familiarity with a click-drag-box to identify six NNS by chemical name (CN) and six NNS by trade name (TN), relative to six decoy NNS, six caloric sweeteners, and six food items (mean ± standard deviation). NNS definitions contained 1.1 ± 1.1 of four previously defined elements suggestive of knowledge depth, with highest scores among self-described non-NNS users and food ingredient label users. Knowledge depth was not correlated with gender, age, American College Test score, or history of weight loss attempts. Without prompting, respondents could name 0.9 ± 1.1 NNS from memory, with highest scores among self-described non-NNS users (1.4 ± 0.8) and food ingredient label users (1.4 ± 0.8). NNS example memory was not correlated with gender, age, ACT score, or history of weight loss attempts. With the click-drag-box exercise, NNS were correctly identified 4.9 ± 1.0 times by TN and significantly less by CN (3.9 ± 1.9 times). Decoy NNS were incorrectly identified as being a real NNS 4.7 ± 1.3 times, while caloric sweeteners and food items were incorrectly identified as NNS 1.7 ± 1.7 times and 1.0 ± 1.5 times, (TN and Decoy NNS > CN > caloric sweetener and food item). NNS knowledge among university students may be inadequate for understanding what NNS are, if they consume NNS, or whether NNS are important for dietary health.
6′-Sialyllactose Ameliorates In Vivo and In Vitro Benign Prostatic Hyperplasia by Regulating the E2F1/pRb–AR Pathway
Authors: Jin Bo-Ram , Kim Hyo-Jung , Kim Eun-Yeong , Chung Tae-Wook , Ha Ki-Tae , An Hyo-Jin
Published: September 2019

Background: 6′-Sialyllactose (6SL) displays a wide range of the bioactive benefits, such as anti-proliferative and anti-angiogenic activities. However, the therapeutic effects of 6SL on benign prostatic hyperplasia (BPH) remain unknown. Methods: Six-week-old male Wistar rats (n = 40) were used for in vivo experiments. All rats were castrated and experimental BPH was induced in castrated rats by intramuscular injection of testosterone, with the exception of those in the control group. Rats with BPH were administrated finasteride and 0.5 or 1.0 mg/kg 6SL. Furthermore, the inhibitory effects of 6SL on human epithelial BPH cell line (BPH-1) cells were determined in vitro. Results: Rats with BPH exhibited outstanding BPH manifestations, including prostate enlargement, histological alterations, and increased prostate-specific antigen (PSA) levels. Compared to those in the BPH group, rats in the 6SL group showed fewer pathological changes and normal androgen events, followed by restoration of retinoblastoma protein (pRb) and cell cycle-related proteins. In BPH-1 cells, treatment with 6SL significantly suppressed the effects on the androgen receptor (AR), PSA, and E2F transcription factor 1 (E2F1)-dependent cell cycle protein expression. Conclusions: 6SL demonstrated anti-proliferative effects in a testosterone-induced BPH rat model and on BPH-1 cells by regulating the pRB/E2F1–AR pathway. According to our results, we suggest that 6SL may be considered a potential agent for the treatment of BPH.
Evaluation of Tobramycin and Ciprofloxacin as a Synergistic Combination Against Hypermutable Pseudomonas Aeruginosa Strains via Mechanism-Based Modelling
Authors: Rees Vanessa E. , Bulitta Jürgen B. , Oliver Antonio , Nation Roger L. , Landersdorfer Cornelia B.
Published: September 2019

Hypermutable Pseudomonas aeruginosa strains have a greatly increased mutation rate and are prevalent in chronic respiratory infections. Initially, we systematically evaluated the time-course of total and resistant populations of hypermutable (PAO∆mutS) and non-hypermutable (PAO1) P. aeruginosa strains in 48-h static concentration time-kill studies with two inocula. Both strains were exposed to clinically relevant concentrations of important antibiotics (aztreonam, ceftazidime, imipenem, meropenem, tobramycin, and ciprofloxacin) in monotherapy. The combination of tobramycin and ciprofloxacin was subsequently assessed in 48-h static concentration time-kill studies against PAO1, PAO∆mutS, and two hypermutable clinical P. aeruginosa strains. Mechanism-based mathematical modelling was conducted to describe the time-course of total and resistant bacteria for all four strains exposed to the combination. With all monotherapies, bacterial regrowth and resistant populations were overall more pronounced for PAO∆mutS compared to PAO1. The combination of tobramycin and ciprofloxacin was synergistic, with up to 106.1 colony forming units (CFU)/mL more bacterial killing than the most active monotherapy for all strains, and largely suppressed less-susceptible populations. This work indicates that monotherapies against hypermutable P. aeruginosa strains are not a viable option. Tobramycin with ciprofloxacin was identified as a promising and tangible option to combat hypermutable P. aeruginosa strains.
Fluorescence Imaging as a Tool in Preclinical Evaluation of Polymer-Based Nano-DDS Systems Intended for Cancer Treatment
Authors: Etrych Tomáš , Janoušková Olga , Chytil Petr
Published: September 2019

Targeted drug delivery using nano-sized carrier systems with targeting functions to malignant and inflammatory tissue and tailored controlled drug release inside targeted tissues or cells has been and is still intensively studied. A detailed understanding of the correlation between the pharmacokinetic properties and structure of the nano-sized carrier is crucial for the successful transition of targeted drug delivery nanomedicines into clinical practice. In preclinical research in particular, fluorescence imaging has become one of the most commonly used powerful imaging tools. Increasing numbers of suitable fluorescent dyes that are excitable in the visible to near-infrared (NIR) wavelengths of the spectrum and the non-invasive nature of the method have significantly expanded the applicability of fluorescence imaging. This chapter summarizes non-invasive fluorescence-based imaging methods and discusses their potential advantages and limitations in the field of drug delivery, especially in anticancer therapy. This chapter focuses on fluorescent imaging from the cellular level up to the highly sophisticated three-dimensional imaging modality at a systemic level. Moreover, we describe the possibility for simultaneous treatment and imaging using fluorescence theranostics and the combination of different imaging techniques, e.g., fluorescence imaging with computed tomography.
The Hazards of a Biomedical Exercise Paradigm: Exploring the Praxis of Exercise Professionals
Authors: Gray John
Published: September 2019

There is a belief that exercise has a major role to play in the current health and wellbeing agendas. Consequently, health interventions are implemented based upon the recommendations of the ACSM and similar exercise research organizations. However this development has been challenged through both social and political perspectives. Specifically accusations of medicalization have been raised against the increasing relationship between the exercise and medical domains. The purpose of this article is to present a similar critique of the growing emergence of a medical paradigm within the exercise domain. In this instance the focus will examine the relationship between exercise professional, exercise science and the proposed medical paradigm. Through the use of philosophical essay and systematic review of literature, it is argued that a continuing shift by exercise science to mirror the medical paradigm will cause a number of issues and potential hazards in the working practices of its professionals.
Sugarcane Omics: An Update on the Current Status of Research and Crop Improvement
Authors: Ali Ahmad , Khan Mehran , Sharif Rahat , Mujtaba Muhammad , Gao San-Ji
Published: September 2019

Sugarcane is an important crop from Poaceae family, contributing about 80% of the total world’s sucrose with an annual value of around US$150 billion. In addition, sugarcane is utilized as a raw material for the production of bioethanol, which is an alternate source of renewable energy. Moving towards sugarcane omics, a remarkable success has been achieved in gene transfer from a wide variety of plant and non-plant sources to sugarcane, with the accessibility of efficient transformation systems, selectable marker genes, and genetic engineering gears. Genetic engineering techniques make possible to clone and characterize useful genes and also to improve commercially important traits in elite sugarcane clones that subsequently lead to the development of an ideal cultivar. Sugarcane is a complex polyploidy crop, and hence no single technique has been found to be the best for the confirmation of polygenic and phenotypic characteristics. To better understand the application of basic omics in sugarcane regarding agronomic characters and industrial quality traits as well as responses to diverse biotic and abiotic stresses, it is important to explore the physiology, genome structure, functional integrity, and collinearity of sugarcane with other more or less similar crops/plants. Genetic improvements in this crop are hampered by its complex genome, low fertility ratio, longer production cycle, and susceptibility to several biotic and abiotic stresses. Biotechnology interventions are expected to pave the way for addressing these obstacles and improving sugarcane crop. Thus, this review article highlights up to date information with respect to how advanced data of omics (genomics, transcriptomic, proteomics and metabolomics) can be employed to improve sugarcane crops.