bluuebunny/crossref_metadata_2025 huggingface dataset:
Differential expression of TCAM1P in cancer of the cervix.
Authors: Mamoor Shahan
Published: May 2023

Almost all cervical cancers are caused by infection with high-risk human papillomaviruses (HPVs) (1-3); the transcriptional features that distinguish the gene expression programs of HPV-induced cancers from that of other solid tumors resulting from non-viral abrogation of tumor suppression remain incompletely defined. We mined published and public microarray datasets (4, 5) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the most common type of cervical cancer, cervical squamous cell carcinoma. We found significant differential expression of the gene encoding testicular cell adhesion molecule 1, pseudogene, TCAM1P, when comparing tumor tissue from the human cervix to the tissue of origin. TCAM1P mRNA was present at significantly higher quantities in tumors of the cervix as compared to normal tissues from the cervix. Analysis of human survival data revealed that expression of TCAM1P in tumors of the cervix was correlated with overall survival in patients with cervical cancer. TCAM1P expression changes may be important for the initiation or progression of cancer of the cervix in humans.
Differential expression of AURKA in cancer of the cervix.
Authors: Mamoor Shahan
Published: May 2023

Almost all cervical cancers are caused by infection with high-risk human papillomaviruses (HPVs) (1-3); the transcriptional features that distinguish the gene expression programs of HPV-induced cancers from that of other solid tumors resulting from non-viral abrogation of tumor suppression remain incompletely defined. We mined published and public microarray datasets (4, 5) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the most common type of cervical cancer, cervical squamous cell carcinoma. We found significant differential expression of the gene encoding aurora kinase A, AURKA, when comparing tumor tissue from the human cervix to the tissue of origin. AURKA mRNA was present at significantly higher quantities in tumors of the cervix as compared to normal tissues from the cervix. Analysis of human survival data revealed that expression of AURKA in tumors of the cervix was correlated with recurrence-free survival in patients with cervical cancer. AURKA expression changes may be important for the initiation or progression of cancer of the cervix in humans.
INKLUSIVISME: MEMBANGUN PERDAMAIAN DALAM MASYARAKAT YANG MULTIKULTUR BERDASARKAN PADA FILOSOFI KEHIDUPAN MASYARAKAT TORAJA
Authors: Paramma Previta Dhea
Published: May 2023

Realitas kehidupan masyarakat yang multikultural memunculkan potensi perdamaian dan sekaligus perpecahan. Inklusivisme yang pada dasarnya sebagai sikap dalam melihat perbedaan sebagai suatu yang bisa diterima, sekaligus sebagai sesuatu yang bisa dikritik dan ditolak. Tulisan ini bertujuan untuk mengkaji mengenai konsep perdamaian dalam masyarakat yang multikultur yang dibangun berdasarkan pada filosofi kehidupan masyarakat toraja yang membuat relasi dalam kehidupan sehari-hari tetap terjalin dengan harmonis sekaligus menganalisis konsep pemikiran inklusivisme terhadap realitas multikultural yang ada dalam masyarakat. Dalam penulisan ini menggunakan pendekatan kualitatif dengan jenis penelitian deskriptif yaitu penelitian yang berusaha untuk menggambarkan atau menjelaskan suatu gejala, peristiwa, atau fenomena yang terjadi dalam kehidupan masyarakat yang multikultur.
Differential expression of RAD51AP1 in cancer of the cervix.
Authors: Mamoor Shahan
Published: May 2023

Almost all cervical cancers are caused by infection with high-risk human papillomaviruses (HPVs) (1-3); the transcriptional features that distinguish the gene expression programs of HPV-induced cancers from that of other solid tumors resulting from non-viral abrogation of tumor suppression remain incompletely defined. We mined published microarray datasets (4, 5) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the most common type of cervical cancer, cervical squamous cell carcinoma. We found significant differential expression of the gene encoding RAD51-associated protein 1, RAD51AP1, when comparing tumor tissue from the human cervix to the tissue of origin. RAD51AP1 mRNA was present at significantly higher quantities in tumors of the cervix as compared to normal tissues from the cervix. Analysis of human survival data revealed that expression of RAD51AP1 in tumors of the cervix was correlated with overall survival in cervical cancer patients with high mutational burden. RAD51AP1 expression changes may be important for the initiation or progression of cancer of the cervix in humans.
The role of mental health in the criminal justice system
Authors: noul asad
Published: May 2023

The role of mental health in the criminal justice system
Differential expression of SYCP2 in cancer of the cervix.
Authors: Mamoor Shahan
Published: May 2023

Almost all cervical cancers are caused by infection with high-risk human papillomaviruses (HPVs) (1-3); the transcriptional features that distinguish the gene expression programs of HPV-induced cancers from that of other solid tumors resulting from non-viral abrogation of tumor suppression remain incompletely defined. We mined published microarray datasets (4, 5) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the most common type of cervical cancer, cervical squamous cell carcinoma. We found significant differential expression of the gene encoding synaptonemal complex protein 2, SYCP2, when comparing tumor tissue from the human cervix to the tissue of origin. SYCP2 mRNA was present at significantly higher quantities in tumors of the cervix as compared to normal tissues from the cervix. Analysis of human survival data revealed that expression of SYCP2 in tumors of the cervix was correlated with overall survival in patients with cervical cancer. SYCP2 expression changes may be important for the initiation or progression of cancer of the cervix in humans.
Juvenile justice reform: evidence-based practices and policy implications
Authors: noul asad
Published: May 2023

Juvenile justice reform: evidence-based practices and policyimplications
Berani dalam Pandangan Hadis
Authors: Hapitasari Sherly Widya
Published: May 2023

Berani adalah sikap mental yang melibatkan keberanian untuk menghadapi ketidakpastian, resiko, dan ketakutan dalam mengambil tindakan atau keputusan yang dianggap penting. Berani merupakan kualitas yang dibutuhkan dalam mengatasi tantangan dan memperoleh kesuksesan dalam hidup. Hal ini dapat diperoleh melalui pembiasaan diri untuk menghadapi ketakutan dan mengejar tujuan dengan tekad yang kuat.
CHAPTER16
Authors: Garcia Ricardo
Published: May 2023

Review Book on The Theory of Univalent FunctionsChapter 16
A review about Green Marketing Studies with AI
Authors: Jerry Leonardus
Published: May 2023

Marketing adalah proses bisnis yang melibatkan perencanaan, pengembangan, pelaksanaan, dan evaluasi strategi pemasaran untuk menciptakan nilai bagi pelanggan dan memenuhi tujuan organisasi. Pada awalnya, fokus pemasaran lebih banyak tertuju pada tujuan-tujuan ekonomi dan keuntungan finansial semata, tanpa mempertimbangkan dampak lingkungan yang ditimbulkan oleh kegiatan bisnis tersebut.Namun, seiring dengan berkembangnya kesadaran masyarakat akan keberlanjutan dan pentingnya menjaga lingkungan, munculah konsep green marketing. Green marketing adalah penggunaan strategi pemasaran yang berfokus pada produk atau layanan yang ramah lingkungan, dengan tujuan untuk meningkatkan kesadaran dan minat pelanggan terhadap produk yang ramah lingkungan.Green marketing mempertimbangkan dampak lingkungan dari kegiatan bisnis, mulai dari penggunaan bahan baku yang berkelanjutan, pengurangan limbah dan emisi, hingga peningkatan efisiensi energi. Tujuan dari green marketing adalah untuk menciptakan nilai tambah bagi pelanggan dengan menawarkan produk yang lebih ramah lingkungan, serta untuk memenuhi tuntutan konsumen yang semakin tinggi akan keberlanjutan dan lingkungan yang bersih.
Barriers and enablers to signing up for a weight management program after receiving an opportunistic referral from a General Practitioner
Authors: Gericke Chiara , Rippy Sterling , D'Lima Danielle
Published: May 2023

Introduction General Practitioners are advised to opportunistically refer patients with overweight or obesity to a tier 2 weight management program, but few patients sign up after receiving the referral. Signing up to a weight management program is a behaviour, as such, behaviour change interventions are needed to increase sign ups. However, no research has explored the influences on signing up after an opportunistic referral specifically and there is a lack of literature studying program uptake using theory-based behavioural science frameworks. Aim To investigate the influences (i.e., barriers and enablers) on signing up to a tier 2 weight management service after receiving an opportunistic referral from a GP, using a theoretical framework to inform intervention development.Method Semi-structured interviews were conducted with eighteen residents from the London borough of Hounslow who were eligible for the service. Interview guides were informed by the Theoretical Domains Framework (TDF). Data were analysed inductively using Reflexive Thematic Analysis and Coding Reliability to identify influences on signing up, before being deductively coded to the TDF and grouped into themes.Results Eight theoretical domains were identified as influences on signing up. Fifteen sub-themes were developed and categorised as either a barrier (5), enabler (3) or mixed (7) influence. Beliefs about Consequences was the most frequently reported influence on signing up. Beliefs that were expressed the most often include how effective the program would be, whether the program is needed to lose weight and whether the program would be compatible with their lifestyle. Leveraging Social Influences and changing patient’s Knowledge could address these beliefs and provide a potential route for behaviour change.DiscussionThe present study provides the first insight into behavioural influences on signing up for a weight management service opportunistically using a validated theoretical framework. This study has implications for intervention development in that public health researchers can identify intervention, content and implementation options based on the findings. Interventions targeting the key domains of Knowledge, Social influences and Beliefs about consequences would likely be the most effective because of their prominence and influence on other domains.
Differential expression of FANCI in cancer of the cervix.
Authors: Mamoor Shahan
Published: May 2023

Almost all cervical cancers are caused by infection with high-risk human papillomaviruses (HPVs) (1-3); the transcriptional features that distinguish the gene expression programs of HPV-induced cancers from that of other solid tumors resulting from non-viral abrogation of tumor suppression remain incompletely defined. We mined published microarray datasets (4, 5) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the most common type of cervical cancer, cervical squamous cell carcinoma. We found significant differential expression of the gene encoding Fanconi anemia complementation group I, FANCI, when comparing tumor tissue from the human cervix to the tissue of origin. FANCI mRNA was present at significantly higher quantities in tumors of the cervix as compared to normal tissues from the cervix. Analysis of human survival data revealed that expression of FANCI in tumors of the cervix was correlated with overall survival in patients with cervical cancer. FANCI expression changes may be important for the initiation or progression of cancer of the cervix in humans.
Police use of force: training and accountability
Authors: noul asad
Published: May 2023

Police use of force: training and accountability
Glacial Isostatic Adjustment reduces past and future Arctic subsea permafrost
Authors: Creel Roger , Miesner Frederieke , Wilkenskjeld Stiig , Austermann Jacqueline , Overduin Pier
Published: May 2023

Sea-level rise submerges terrestrial permafrost in the Arctic, turning it into subsea permafrost. Subsea permafrost underlies ∼1.8 million km^2 of Arctic continental shelf, with thicknesses in places exceeding 700 m. Sea-level variations over glacial-interglacial cycles control subsea permafrost distribution and thickness, yet no permafrost model has accounted for glacial isostatic adjustment (GIA), which deviates local sea level from the global mean due to changes in ice and ocean loading. We incorporate GIA into a pan-Arctic model of subsea permafrost over the last 400,000 years. Including GIA significantly reduces present-day subsea permafrost thickness, chiefly because of hydro-isostatic effects as well as deformation related to Northern Hemisphere ice sheets. Additionally, we extend the simulation 1000 years into the future for emissions scenarios outlined in the Intergovernmental Panel on Climate Change’s sixth assessment report. We find that subsea permafrost is preserved under a low emissions scenario but mostly disappears under a high emissions scenario
National-scale, remotely sensed lake trophic state, 1984-2020
Authors: Meyer Michael , Topp Simon , King Tyler , Ladwig Robert , Pilla Rachel , Dugan Hilary , Eggleston Jack , Hampton Stephanie , Leech Dina , Oleksy Isabella , Ross Jesse , Ross Matthew , Woolway R Iestyn , Yang Xiao , Brousil Matthew , Fickas Kate , Padowski Julie , Pollard Amina , Ren Jianning , Zwart Jacob
Published: May 2023

Lake trophic state is a key ecosystem property that integrates a lake’s physical, chemical, and biological processes. Despite the importance of trophic state as a gauge of lake water quality, standardized and machine-readable observations are uncommon. Remote sensing presents an opportunity to detect and analyze lake trophic state with reproducible, robust methods across time and space. We used Landsat surface reflectance data to create the first compendium of annual lake trophic state for 55,662 lakes of at least 10 ha in size throughout the contiguous United States from 1984 through 2020. The dataset was constructed with FAIR data principles (Findable, Accessible, Interoperable, and Reproducible) in mind, where data are publicly available, relational keys from parent datasets are retained, and all data wrangling and modeling routines are scripted for future reuse. Together, this resource offers critical data to address basic and applied research questions about lake water quality at a suite of spatial and temporal scales.
Tracking meaning evolution in the brain: Processing consequences of conventionalization
Authors: Schumacher Petra B. , Weiland-Breckle Hanna , Reul Guendalina , Brilmayer Ingmar
Published: May 2023

Language users employ creative and innovative means to refer to novel concepts. One example is place-for-event metonymy as in “How many bands played at Woodstock?” where the place name is used to refer to an event. We capitalize on the observation that place-for-event metonymy can on the one hand result in the conventionalization of the event reading (as is the case for “Woodstock”) but on the other hand can also be relatively short-lived as a function of the socio-cultural or historical impact of the respective event (e.g., “Egypt” to refer to one of the sites of the Arab Spring). We use place-for-event metonymy as a test case to tap into discrete stages of conventionalization and compare the processing of the place and the event reading of particular expressions, with ratings of the degree of conventionalization as predictors. In an event-related potential (ERP) reading study, we observed a modulation of the Late Positivity between 500-750 ms post-onset by condition (event vs. place reading) and degree of conventionalization. The amplitude of the positivity was most pronounced for event readings with a low degree of conventionalization (similar to previous findings from ad-hoc metonymy). Interestingly, place readings with a high degree of (event) conventionalization also evoked a pronounced positivity. The Late Positivity is viewed to reflect processing demands during reconceptualization required for proper utterance interpretation. Overall, the data suggest that stages of meaning evolution are reflected in the underlying neurophysiological processes.
Models of unforced choice
Authors: Cervantes Victor Hernando , Benjamin Aaron
Published: May 2023

Unforced choice tasks are ones in which the responder has the option of selecting from a limited array of choices or rejecting the entire set. Such tasks are common in perceptual and cognitive research, but models of decision-making for unforced choice are sparse in the literature and lack a unifying mathematical framework. Such tasks are important for theoretical development because they contain elements of relative, criterion-independent decision making---in which response options are compared to one another---and also criterion-dependent decision making, in which options are compared to a decision criterion determined by the observer. We provide a generic signal-detection multivariate framework for developing models of unforced choice that draws lessons from the geometry of multivariate statistics, from multidimensional signal-detection theories, and from psychophysical models of visual search. We show how this framework can accommodate all extant models of unforced choice that have been applied to the specific case of lineup memory tasks for eyewitnesses. Exact derivations, some of which have proven elusive to this point, are provided for each model in both an unrestricted form---in which variances and covariances are relatively free to vary across signal and noise---and in various restricted forms, in which constraints are applied to variances and covariances. Using the formalizations presented here, we show that all of the current models of lineup memory have severe limitations that render some models challenging to directly compare to one another and other models unidentifiable. Overall, the multivariate framework will aid in the testing of current models and in the development of new models of lineup memory and other tasks involving unforced choice.
Frontotemporal dementia or frontal variant Alzheimer's disease? A case series
Authors: Powell Alice , Foxe David , Halliday Glenda M. , Piguet Olivier , Hodges John , Burrell James R.
Published: May 2023

Introduction: Accurate prediction of the underlying neuropathology in behavioural variant frontotemporal dementia (bvFTD) is challenging but essential for future targeted therapy trials and prognostication. Alzheimer’s disease (AD) pathology has been reported in a significant proportion of patients with clinical bvFTD. We sought to determine whether detailed clinical and neuroradiological assessment was sufficient to distinguish bvFTD with AD pathology from bvFTD with frontotemporal lobar degeneration (FTLD). Methods: Two patients with clinically diagnosed probable bvFTD but AD pathology at autopsy were identified. The clinical, neuropsychological and imaging features of these patients were compared with those of ten patients with clinically probable bvFTD and proven FTLD pathology (i.e. tau, TDP-43, FUS). Results: Both patients with AD pathology presented with behavioural symptoms typical of bvFTD as well as memory impairment. Executive function, memory and visuospatial skills were impaired in both pathologic groups. Language skills were relatively spared in those with AD pathology. Neuropsychiatric symptoms were frequent in both groups but significant depression and anxiety were seen only in those with FTLD pathology. Dementia severity and caregiver burden were similar across the groups. The degree or topographical distribution of atrophy did not differ on review of MRI data. Discussion: Alzheimer’s pathology may cause bvFTD symptoms which are otherwise indistinguishable to those caused by FTLD pathology. While there may be subtle differences in patterns of cognitive deficits, standard neuropsychological testing is insufficient to discern the underlying pathology. Similarly, structural imaging cannot be used to reliably identify AD pathology. Better access to amyloid biomarkers may be needed to more accurately define bvFTD caused by AD pathology.
Categorical Learning and the Cognitive Foundations of Language Evolution and Development
Authors: Zhang Elizabeth Qing , Shi Edward Ruoyang , Pleyer Michael
Published: May 2023

Categorical learning plays a foundational role in language development. By reviewing comparative studies on categorical learning in humans and nonhuman animals, we show that categorical learning displays evolutionary continuity across invertebrates and vertebrates. Great apes and parrots can be trained to produce categories of (proto-)language-like symbols in different modalities. From the neurological perspective, we show that as a conserved brain structure, the basal ganglia are involved in categorical learning across species, and language processing in humans. This raises the possibility that categorical learning is one of the crucial cognitive foundations for language evolution.
Pengantar Bisnis (Respons Dinamika Era Digital)
Authors: Agusfianto Nendy Pratama , Andayani Sri Umiatun , Anwar  , Sihombing Lukertina , Setiawan Adi , Amelia Dahlia , Gunawan Ce , Indraswati Tris Dewi , Wati Krisna Mutiara , Octasylva Annuridya Rosyidta Pratiwi , Sari Dina Purnama , Nurbismi  , Kamal Edwin , Luthfiyani Ulfah Khairiyah , Sijabat Ferdi Nazirun , Wijayanto Sigit Ary
Published: May 2023

Sebagian besar aktivitas bisnis kini tengah bergeser dari metode konvensional-tradisional ke arah bisnis dengan memanfaatkan kemajuan teknologi dan informasi digital yang semakin mudah diakses oleh siapapun dan di manapun. Hal ini membuat para pelaku bisnis perlu merespon dan beradaptasi dengan dinamika tersebut.Menjawab fenomena di atas, maka buku ini hadir untuk membantu para pembacanya yang ingin memahami konseptual dasar bisnis yang dibekali dengan pendekatan teknologi dan informasi digital.Adapun isi pembahasan dalam buku ini terdiri dari 16 bab yang saling terhubung, yaitu: Konsep dan Teori-teori Bisnis; Etika dan Perilaku Bisnis; Konsep Studi Kelayakan Bisnis; Manajemen Risiko Bisnis Umum; Transformasi Bisnis ke Sistem Digital; Peluang dan Pemanfaatan Digitalisasi Bisnis; Rantai Pasokan Digital; Internet of Things (IoT) dalam Bisnis; Website dan Media Sosial; Mobile Business; E-Commerce; Pembayaran Digital; Konsep Dasar Cloud Computing; Mengenal Cybersecurity; Pemanfaatan Artificial Intelligence (AI); Evaluasi Kinerja Bisnis.
Anatomy and Variants of Hepatic Arteries in 120 Patients Studied with 128 Slice Volumetric Scan in Nepalese Population
Authors: Paudel Bigyan , Adhikari Deepak , Raut Yuv Raj , Paudyal Sudil
Published: May 2023

Introduction: Modern advances in radiology, imaging, and novel surgical methods have greatly aided doctors in making both surgical and non-surgical decisions. During surgery, anatomical variances are frequently encountered by surgeons, making operation complex and occasionally challenging. The purpose of our study was to evaluate the hepatic artery and its variants, including the length and diameter of the right and left hepatic arteries. This information is vital for patients undergoing major hepatic surgeries and hepatic transplantation
Methods: A total of 120 patients who underwent contrast-enhanced Triphasic CT of the abdomen were evaluated with the consent of the ethics committee at Chitwan medical college. Study subjects were selected on a random basis, who had no previous abdominal or hepatic surgeries, and without the known hepatic disease.
Results: Out of 120 participants, 63 (52.5%) were male and the rest 57(47.5 %) were females. Normal anatomy was observed in 104 cases (86.7%) and the rest of the 16 cases showed an anomalous hepatic arterial pattern, which consisted of Michel’s type III in 6 cases (5%), Type IV in 1 case (0.8%) and Type X in 3 cases (2.5%); and 5 cases (4.2%). did not fall under Michel’s Classification. Supply to segment IV of the liver was observed from Left hepatic artery in 97 cases (80.8%) and from the right hepatic artery in 23 cases (19.2%).
Conclusions: Many hepatic arterial variants which did not fall under Michel’s classification were observed in our population.
Retroperitoneal Seminoma in Undescended Testis: A Case Report
Authors: Paudel Sharma , Kayastha Prakash , Suwal Sundar , Singh Shashi Shekhar , Gautam Bishnu , Chataut Dinesh
Published: May 2023

Testicular seminoma needs to be considered as a differential diagnosis for intra-abdominal mass in the male patient if there is a history of undescended testis. The risk of developing seminoma in an undescended testis is about 4-7.5 times greater than in a normally located testis.The risk of seminoma in undescended testis is increased even after orchidopexy.The identification of the draining gonadal vein can play a key role in the diagnosis of the testicular tumor in undescended intra-abdominally located testis. We report a case of seminoma in the retroperitoneal undescended testis in 50 years old male admitted for abdominal pain and distension
'गाउँमा गीतहरू गुन्जिदैनन्' कथामा अभिघात {Trauma in the Story Gaunma Geetharu Gunjidainan}
Authors: भट्टराई Bhattarai टंकप्रसाद Tankaprasad
Published: May 2023

प्रस्तुत अनुसन्धानात्मक लेख नेपाली जनजीवनमा व्याप्त अभिघातपरक अवस्थितिको प्रभावमा परेका जनताकस्तो भयाक्रान्त अवस्थामा बाचिरहेका छन् भन्ने सन्दर्भसँग सम्बन्धित छ । नेपाली समाजमा समयसमयमाहुँदै आएका द्वन्द्व र तिनले समाजमा पार्ने प्रभावलाई प्रस्तुत गर्ने क्रममा नेपाली साहित्यमा अभिघातपरककथाकारको रूपमा विशिष्ट पहिचान बनाएका महेशविक्रम शाहको 'गाउँमा गीतहरू गुन्जिदैनन्’ कथालाईअध्ययनको आधार सामग्री चयन गरिएको छ । हिंसात्मक द्वन्द्वले समाज कसरी आक्रान्त बन्दछ, गाउँहरूमानिर्मित विकासका संरचनाहरू कसरी ध्वस्त पारिन्छन्, मान्छेहरू आफ्नै परिवार समाजमा आफूलाई कतिसम्मअसुरक्षित महसुस गर्न पुग्दछन् र त्यसको नतिजा कतिसम्म ध्वंशात्मक हुन्छ भन्ने कुराको पहिचान गराउनु नैप्रस्तुत लेखको महत्त्वपूर्ण पक्ष हो । यही सन्दर्भमा केन्द्रित रहेर यस अनुसन्धान लेखको निष्कर्ष निकालिएको छ ।
{The present article deals with the context in which the people affected by the traumatic situation in Nepali life. Mahesh Vikram Shah's story ' Gaunma Geetharu Gunjidainan has been selected as the basis material for the study while presenting the conflicts in Nepali society from time to time and its impact on the society. An important aspect of this article is to identify how violent conflicts attack  society, how development structures built in villages are destroyed, how people feel insecure in their own family society and how destructive the consequences are. In this context, the findings of this research article are drawn.}
सङ्‍घीय नेपालको सार्वजनिक वित्त व्यवस्थापन
Authors: वाग्ले Wagle अच्युत Achyut
Published: May 2023

सङ्‍घीय राज्य संरचनाको सबैभन्दा आकर्षक पक्ष ‘वित्तीय सङ्‍घीयता’ जसले सङ्‍घीय राज्य प्रणालीमा सङ्‍घीय एकाइहरूले गर्ने सार्वजनिक वित्त व्यवस्थापन र विभिन्न तहका सरकारहरूबिचको आर्थिक कारोबारलाई परिभाषित र परिचालित गर्छ । खासगरी उपराष्ट्रिय तहहरू (Subnational Levels) लाई दिइने खर्चको जिम्मेवारी, राजस्वको क्षेत्राधिकार, अन्तरसरकारी वित्तीय हस्तान्तरण, वित्तीय पारदर्शिता र आर्थिक सुशासन, उपराष्ट्रिय तहहरूको ऋण उठाउने अधिकार, ऋण दिगोपन वित्तीय सङ्‍घीयताका प्रमुख अवयवहरू हुन् । नेपालको संविधानले सङ्‍घीय, प्रादेशिक र स्थानीयसहित तीनै तहका सरकारहरूलाई ‘आफ्नै’ बजेट तर्जुमा गर्ने अधिकार दिएको छ । अहिले प्रादेशिक र स्थानीय तहको सार्वजनिक वित्त व्यवस्थापनमा सबैभन्दा ठुलो चुनौती मानवस्रोत व्यवस्थापन देखिएको छ । योजना निर्माण, तिनको प्राथमिकीकरण, त्यसअनुरूपको बजेट लेखन, सार्वजनिक खरिद, योजना कार्यान्वयन, खर्च प्रभावकारिता र खर्च अनुगमनसम्मका लागि प्रदेशस्तरमै पनि विषयगत र क्षेत्रगत दक्षता भएका जनशक्ति पाउन र उनीहरूलाई टिकाइराख्न मुस्किल परिरहेको छ । साथमा अनुदान, राजश्व र अन्य आर्थिक स्रोतहरूको बाँडफाँटका सूत्रहरूको पुनरावलोकन र सबै तहमा सार्वजनिक वित्त व्यवस्थापनको क्षमता वृद्धि अपरिहार्य देखिएको छ। यो लेख नेपालको वित्तीय सङ्‍घीयतासम्बद्ध नीतिगत, संरचनागत र सञ्चालनगत पक्षहरूको समीक्षामा केन्द्रित छ ।
Community Based Organization Governance in Nepal
Authors: Paudel Narendra Raj
Published: May 2023

Globally diversity of Civil Society Organizations (CSOs) applications raises the curiosity to analyze CSOs’ application in Nepal due to uncoerced collective action around shared interest purposes and values. The study focuses on the analysis of the structure, environment, values and impacts of CSOs to illustrate CSO governance. Based on the four types of Nepalese CSOs- Community Forest Users Groups (CFUGs), Cooperatives, Non-governmental Organizations (NGOs), Not-profit Making Organizations and Community Organizations due to the availability of their data. The findings reveal that CSOs have wide coverage and networking throughout the country having voluntary in nature and autonomous in working style. However, their performance is conditioned by the availability of donors’ funds, and elite-captured, begging tools in the name of democratic-value addition except not profit-making CSOs due to individualization of the social members.
Pendampingan Pelaku Ekonomi Kreatif Makanan Siap Saji Berbasis Singkong Di Desa Gading Kembar Kec. Jabung, Kab. Malang
Authors: Machfudz Masyhuri , Rianti Titis Surya Maha , Nadhiroh Umi
Published: May 2023

Tujuan program pengabdian ini adalah untuk memunculkan potensi produksi singkong menjadi suatu produk olahan dan bentuk deversifikasi produk yang ada di Desa Gading Kembar. Selain itu dengan kegiatan ini diharapkan dapat memunculkan sedini mungkin calon wirausaha, menawarkan ‘solusi’ permasaalah umum yang esensi dan pemasaran produk. Metode yang dipakai dalam melaksanakan program pengabdian ini adalah program aksi (action) yang mengedepankan kesepakatan (agreement) berbasis FGD. Mekanisme pelaksanan pengabdian melalui ceramah dan praktek baik aspek produksi maupun pemasaran. Hasil program pengabdian menunjukkan bahwa (1) kepakatan (agreement) pemebrdayaan singkong guna memunculkan konsep terinpirasi one village on product, berupa mocaf. Disamping telah ada sebelumnya berupa kripik singkong; (2) upaya  memunculkan sedini mungkin kelompok calon wirausaha baru (start-up) singkong sebagai komoditas yang mempunyai nilai daya gengsi (prestisius); (3) optimalisasi kemajuan teknologi untuk pemasaran manual dan on-line sebagai aktualisasi dari pengabdian yang menjadikan tawaran solusi dalam pemasaran produk, dan (4) ’solusi’ pada masyarakat umum adalah kelangkaan pupuk yang ini menjadi bahan pengabdian dimasa yang datang. Saran yang disampaikan ada 3 (tiga), yaitu (1) kemitraan telah terbangun pada kelompok ibu-ibu PKK, pelaku UMKM dan gabungan kelompok tani (GAPOTAN) perlu dipertahankan; (2)  inptek yang diintruduksikan berupa mocaf sebagai penambahan pada deversifikasi pada konsep ‘on village one product’ di Desa gading Kembar; dan (3) diharapkan pada program ini ada keberlanjutan yang akan dilakukan program pengabdian yang berkesinambungan khususnya berkaitan dengan solusi tawaran berupa kelangkaan pupuk sebagai kebutuhan petani produsen dalam berusahatani.
E-Libra Media Bantu Minat Baca Yang Asik Bagi Siswa Sekolah Dasar
Authors: Zulkifli Zulkifli , Wahyuningtyas Nabilah , Hoar Maria Apriani , Shofiah Shofiah , Firdiansah Irgi , Maulana Alvin Viki
Published: May 2023

Meningkatkan minat baca bagi siswa yang duduk di bangku sekolah dasar merupakan hal yang harus terus ditingkatkan untuk memperluas pengetahuan. SDN 2 Sumberpasir mengalami kesulitan dalam pengadaan buku yang juga menjadi faktor penghambat dalam meningkatkan minat baca siswa. Dengan adanya permasalahan tersebut kami menciptakan E-libra yang memiliki fungsi menggantikan buku-buku yang sulit diadakan oleh pihak sekolah, untuk mempermudah siswa menemukan bacaan yang sesuai.
Pembuatan Instalasi Pengolahan Limbah (IPAL) Berbasis Eco-green di SDN Madyopuro 2 Malang
Authors: Sudjianto Agus Tugas , Zulkifli Zulkifli , Paramita Niken , Tjahjono Ngudi , Faried Muhammad Yussac
Published: May 2023

Air merupakan suatu kebutuhan kebutuhan dasar manusia, dimana meningkatnya populasi manusia diiringi peningkatan kebutuhan konsumsi air. Penggunaan air untuk berbagai kegiatan menghasilkan limbah cair domestik yang berasal dari kegiatan mandi, cuci dan kakus. Air limbah domestik biasanya dibuang ke saluran air menuju sungai dapat menurunkan kualitas air dan fungsi air untuk kehidupan makhluk hidup akibat pencemaran air permukaan. Tujuan penelitian ini adalah pembuatan Instalasi Pengolahan Air Limbah (IPAL) skala rumah tangga berbasis ekogreen. Dimana hasil air limbah di sekolah dimanfatkan untuk menyiram tanaman atau dengan kata lain sekolah berwawasan ramah lingkungan yang membangun kesadaran siswa untuk menjaga dan melindungi kehidupan lain dilingkungan. Pengamatan ini dilakukan secara langsung di SDN Negeri 2 Madyopuro Kota Malang dengan tujuan untuk membangun kesadaran siswa dalam mencintai dan melestarikan lingkungan melalui pembuatan dan pemanfaatan IPAL sekolah.
Pelatihan Pembuatan Laporan Keuangan Berbasis Digital Menggunakan Aplikasi BukuKas pada UMKM Aneka Keripik Cap Kenari
Authors: Hastuti Tuti , Solihah Ulfi Alifatu , Aulinah Ina , Krisbiantoro Aldy
Published: May 2023

UMKM Aneka Keripik Cap Kenari bergerak dalam bidang produksi aneka keripik utamanya keripik singkong dan keripik talas mengalami kesulitan dalam mengelola keuangan karena keterbatasan pengetahuan dalam membuat laporan keuangan. Kegiatan pelatihan ini bertujuan untuk memberi pengetahuan dan keterampilan dalam membuat laporan keuangan berbasis digital dengan memanfaatkan aplikasi BukuKas bagi mitra pengabdian, UMKM Aneka Keripik Cap Kenari. Untuk mencapai tujuan tersebut digunakan metode pendekatan, metode pelatihan, dan metode pendampingan. Hasilnya, UMKM Aneka Keripik Cap Kenari telah dapat mencatat transaksi pemasukan dan pengeluaran, mencatat stok barang, mengetahui keuntungan dan kerugian pada tiap penjualan, serta mengetahui laporan keuangan otomatis. UMKM Aneka Keripik Cap Kenari menganggap bahwa kegiatan pelatihan ini sangat bermanfaat dalam membantu melakukan pencatatan dan pengelolaan keuangan usaha secara digital dengan mudah, cepat, dan praktis menggunakan aplikasi BukuKas.
Pemanfaatan Limbah Kertas Duplex Sebagai Bahan Pengganti Tembaga Pada Canting Cap UMKM Batik Tulis Lintang Dan Sosialisasi Kepada`Masyarakat Sekitar
Authors: Miladiyanto Sulthon , Pangestuti Restu Siwi , Rahmadani Rani , Maulana Yusril Iqbal
Published: May 2023

Batik merupakan hasil karya yang menjadi kebanggaan Bangsa Indonesia. UMKM yang menjalankan usaha kerajinan batik di Indonesia juga banyak, salah satunya UMKM Batik Tulis Lintang yang berlokasi di Kabupaten Malang, tepatnya di Desa Ngijo, Karangploso. Batik Tulis Lintang merupakan salah satu UMKM penghasil Batik Malangan yang berkontribusi dalam melestarikan budaya warisan leluhur. Untuk produksi massal dan lebih cepat, Batik Tulis Lintang menggunakan canting cap dari tembaga yang memiliki harga relatif mahal. Dari banyaknya limbah kertas duplex yang masih dapat didaur ulang sebagai pengganti tembaga untuk canting cap, diharapkan mampu menekan biaya yang dikeluarkan oleh UMKM Batik Tulis Lintang. Tujuan dari penelitian ini adalah untuk membuat canting cap dari limbah kertas duplex yang jauh lebih terjangkau harganya dan melakukan sosialisasi penggunaan canting cap hasil daur ulang ini kepada masyarakat sekitar UMKM. Metode pelaksanaan pembuatan canting cap dari limbah kertas duplex diawali dengan pengumpulan limbah kertas duplex dan bahan lain yang dibutuhkan seperti kayu dan kertas karton lalu dipilah yang masih dapat digunakan, serta membeli peralatan yang dibutuhkan. Kemudian membuat pola pada kertas karton dengan ukuran yang dibutuhkan, lalu memotong kertas duplex harus dengan tinggi yang rata. Tinggi idealnya yaitu 1,5 cm agar lebih mudah dalam merekatkan kertas duplex ke pola yang rumit. Yang terakhir, lem kertas duplex yang sudah dipotong pada kertas karton lalu kertas karton ditempelkan pada papan kayu yang telah disiapkan sebelumnya agar lebih kuat dan solid ketika digunakan. Hasil canting cap dari limbah kertas duplex dengan tinggi 1,5cm pada percobaan menghasilkan cap yang bagus dan lebih mudah diaplikasikan dan pastinya dengan biaya yang terjangkau. Setelah percobaan berhasil, dilaksanakanlah sosialisasi penggunaan canting cap dari limbah kertas duplex kepada masyarakat sekitar UMKM Batik Tulis Lintang.
Pemberdayaan UMKM Melalui Peningkatan Produktivitas dan Market di Era Digital
Authors: Marisa Fitri , Subakti Dedi Eryan , Anastasya Nita , Muktiyanto Robby , Maulana Jefri Angga
Published: May 2023

Usaha Masyarakat Kecil Menengah (UMKM) salah satu usaha yang diharapkan bisa meningkatkan kualitas hidup masyarakat. Salah satu bisnis UMKM Sumber Rejeki terletak di daerah Kecamatan Lawang, Kabupaten Malang, Jawa Timur. UMKM ini merupakan sebuah usaha kecil menengah yang memproduksi makanan olahan sempol dan rolade yang masih mengandalkan produksinya menggunakan pralatan yang masih manual, selain itu pemasarannya masih bersifat lokal dan tidak adanya pemasaran pada sosial media karena lemahnya wawasan terkait penggunaan teknologi yang tepat dalam pemasaran produksi dan kurang menariknya suatu kemasan produk, berdampak pada kurangnya jangkauan pasar dalam pendistribusian produk sehingga lingkup pendistribusiannya kurang dan target penjualan kurang maksimal. Untuk itu kami mengusulkan sebuah inovasi yaitu dengan melakukan pembaharuan sistem penggunaan alat produksi olahan sempol dan rolade sehingga mempercepat proses produksi dan desain kemasan produk yang menarik serta memaksimalkan proses pemasaran dengan memanfaatkan penggunaan website dan pemasangan iklan di beberapa sosial media yang sedang trending di masyarakat. Dengan adanya pembaharuan pada alat produksi, kemasan produk dan proses pemasaran ini, diharapkan dapat menarik minat konsumen sehingga dapat meningkatkan target penjualan produk.
Becoming Reflective Practitioners: Gender GAP Analysis of Mathematics Student Teachers’ Reflective Practices
Authors: Olawale Babawande Emmanuel , Hendricks Winston
Published: May 2023

While reflective thinking practices are thought to be a factor in building bridges between a course of study and personal experience resulting in engaging and personalized learning activities, the present study examined the potential disparities in reflective thinking practices and how they influence preservice mathematics teachers' behavior. Underpinned by a positivist paradigm, the present study employed a quantitative research approach and a survey design. Data was collected from three hundred and fifty-nine mathematics student teachers who were preparing to become mathematics teachers once they had obtained a Bachelor of Education (B.Ed.) degree. Data collected was therefore analyzed through the use of descriptive statistics. Lifelong learning skills, self-assessment, self-belief, teaching awareness, and reflective thinking were all examined using a framework based on five components. Research findings revealed that while reflective thinking practices are often emphasized in teacher education programs, results clearly show that the process of reflective practices is conceptualized differently by female and male participants. Research findings also revealed that constructs such as lifelong learning skills, self-assessment ability, and teaching awareness have a more decisive influence on male participants than their female counterparts. This resulted in male participants having less perception of the usefulness of reflective thinking practices. Based on the findings, it was suggested that various support systems should be developed in mathematics teacher education programs to facilitate more independent and self-directed reflective thinking practices among both female and male mathematics students teachers.

Keywords: Classroom Practices, Gender GAP, Reflective Thinking, Self-Belief, Teacher Education.
"حوكمة الأمن الإقليمي، وتوقعات الجمهور وأدوار السياسة الخارجية شمال أفريقيا ومطلبها أن تحافظ تونس على "نأيها الاستراتيجي
Authors: منصور عماد , دانيلز هيكس جون
Published: May 2023

من خلال دراسة السياسة الخارجية التونسية في العقد الذي تلا الانتفاضات الشعبية عام 2010 ، تسهم هذه الدراسة في نظرية الدور، عن طريق شرح كيفية تأثير توقعات الجمهور الإقليمي في أدوار السياسة الخارجية. وتوضّح الدراسة كيفية تطوير الأدوار المحققة للتوقعات بين دول المنطقة بصفتها الجمهور، ثمّ تشرح كيف أنّ هذه التوقعات تحدّد الدور، وتُظهر كيفية تطوير تونس لموقف السياسة الخارجية، ثمّ عمّقته، وهو متمثّل في نأي استراتيجي يتميّز بالحياد في النزاعات الإقليمية، والالتزام بالشرعية، والسعي لتحقيق المصالح الاقتصادية. لقد أصبح النأي الاستراتيجي بالنسبة إلى تونس أمرًا متوقّعًا من دول شمال أفريقيا.
سياسة إسرائيل تجاه المشروع النووي الإيراني في العامين الأخيرين
Authors: محارب محمود
Published: May 2023

تتلخص الفرضية الأساسية للدراسة في سعي إسرائيل الدائم للحفاظ على احتكارها الساح النووي في الشرق الأوسط أطول فترة ممكنة، وقيامها بمختلف النشاطات السياسية والدبلوماسية والأمنية والعسكرية والاقتصادية لمنع إيران، وأي دولة أخرى في الشرق الأوسط، من احتكار الساح النووي. تتابع الدراسة سياسة إسرائيل التي تدعو إلى فرض أقصى العقوبات الاقتصادية الدولية على إيران، التي تتجلى في تخليها كلية عن المشروع النووي أو إسقاط النظام الإيراني. وتعرض سياسة إسرائيل تجاه مفاوضات العودة إلى الاتفاق النووي الإيراني، وتقف على الارتباك الاستراتيجي الذي وجدت إسرائيل نفسها فيه، من جراء العديد من الفرضيات المخطئة التي تبنتها حكومة بنيامين نتنياهو تجاه المشروع النووي الإيراني، وتعرض أهداف إسرائيل من "المعركة بين الحروب" التي تشنها ضد إيران، وتقف على الاستراتيجية الكبرى ضد إيران التي ينادي بها منظرو المؤسسة العسكرية الإسرائيلية، وتتابع سعي إسرائيل لإقامة حلف عسكري إسرائيلي - عربي - أميركي ضد إيران، وتعرض التصور الإسرائيلي للهجوم العسكري الإسرائيلي على المنشآت النووية الإيرانية والمخاطر والمشكلات التي تواجهه.
EXERCINAS: NOVOS HORIZONTES NA BIOLOGIA DO EXERCÍCIO FÍSICO
Authors: Yamada André Katayama
Published: May 2023

Duas décadas atrás um grupo de pesquisadores descobriu que a contração muscular produz peptídeos que conferem benefícios a outros órgãos, levando a uma nova era da comunicação-inter-órgãos. Esses peptídeos foram denominados de miocinas, e atualmente se sabe que vários outros órgãos como o fígado, cérebro e tecido adiposo produzem tais substâncias. As exercinas têm papel importante na cognição, metabolismo lipídico e glicídico, browning do tecido adiposo branco, formação óssea, função da célula endotelial, função da célula ?, hipertrofia muscular, estrutura da pele e crescimento tumoral. Assim, o objetivo desta a “palavra é sua” é descrever/atualizar de forma sucinta a ciência das exercinas na biologia do exercício físico.
Adults Myelodysplastic Syndromes in Algeria: A Study by the Algerian MDS Group
Authors: Bekadja Mohamed Amine , Fenaux Pierre , Akrouf Sabrina , Ahmed-Nacer Redhouane , Hamladji Rose-marie , Bouchakour Amina , Taoussi Souad , Abad Mohand Tahar , Bradai Mohamed , Benzineb Brahim , Mesli Naima , Cheritti M , Zouaoui Z , Benlazar Mohamed , Bougherira Soraya , Grifi Fatiha , Ait-Ali Hocine , Allouda Malika , Djillali Malika , Djouadi Khadija , Kherbache Fatima , Hamdi Selma , Hamouda Hakim , Boumeida Imene , Belhani Meriem , Boudjerra Nadia , Kaci Fatima Zohra , Osmani Soufi , Yafour Nabil , Barkat Soumia , Soltani Fatma , Nacib Razika , Saidi Mahdia , Touati Laid , Lakhdari Noureddine , Zouani Samira , Touhami Hadj , Saidi Djamel , Cherif Louazani Lamia , Ramaoun Mohamed , Akkal Cherifa , Mehalhal Nemra , Krim Amina , Sidimansour Noureddine , Ouchenane Zohra , Zidani Nadia , Nekkal Salim , Barkat Samia , Ouarlent Y , Aberkane Mohamed , Belakehal Salah Eddine , Bachiri Aissa , Baghdad Samir
Published: May 2023

Introduction: Myelodysplastic syndromes (MDS) are a group of haematological disorders, whose diagnosis is based mainly on cytological studies of blood and marrow cells and cytogenetic analysis. Moreover, national epidemiological data on MDS are very scarce, especially in Maghreb countries where the population is on average younger than in Europe or the USA. The objective of the present study was to describe demographic and clinical features and the overall survival of patients with MDS in Algeria. Materials and Methods: This study is retrospective and national multicenter (n=19 centres), performed between 2014 to 2019. The evaluation was performed using EPI-INFO and SPSS version 21 software. Survival data were calculated using the Kaplan-Meier method and comparison of survival curves using the Log Rank test. Univariate and multivariate analysis of survival was performed using the Cox regression method. The study has been approved by the Ethical and Scientific Council of the participating hospitals. The closing date of the study is 31/12/2019. Results: A total of 670 patients with newly diagnosed MDS have been identified. The average number of new cases was 112/year, with an annual progression rate of 19%. Demographics show a slight female predominance (M/F of 317/353=0, 89; sex ratio F/M=1.11). The median follow-up was 29,3 months (range, 1 to 77 months). The overall median age was 69 years (range 16-96). The crude mean annual incidence rate was 0, 38 per 100,000 inhabitants aged ≥15 years old and it was 0, 17/100,000 in men and 0, 21/100,000 in women. Overall survival was 39 months. According to the IPSS score, the high-risk forms are low and their overall survival was 15 months. The rate of transformation into acute myeloid leukaemia (AML) is 32%. Conclusion: This national epidemiological survey shows an annual progression rate of 19% and an increase in incidence from 0.007/100.000 in 2005 to 0.45/100.000 in 2019.
Mechanism of Action p53
Authors: Ali Ghorbat Saleh
Published: May 2023

P53 is a 393 residue protein in humans made up of five proposed domains, with which the central DNA binding domain with 100-300 sequences very important for the direct binding of p53 in the promoters of its target genes to specific response elements. P53 is a tumor suppressor gene with cellular stress like oxygen deficiency, oxidative stress, radiation and carcinogens substances, is stimulated has major roles in translational regulation and feedback processes. A wide variety of damage signals that relate to the stability, post-translational alteration and recruitment of p53 to binding sites in chromatin which activate the p53 pathway. As a transcriptional activation, p53 mediates transcriptional changes which facilitate cell death, senescence or reversing and protective arrest of the cell cycle. P53 is a protein under intense investigation because it is necessary to prevent tumor, in human tumors have been found to deregulation of p53 activity. On this article study focuses the mechanism of suppressive p53 effects in the response to any stress and correlation of the mutation p53 with different tumor.