bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategi Pemberantasan Praktik Penangkapan Ikan Secara Ilegal di Wilayah Laut Indonesia
Authors: Darajati Muhammad Rafi , Syafei Muhammad
Published: November 2022

Maritime security in Indonesia is still vulnerable because of the high level of violations at sea such as illegal fishing, as well as various threats and other problems. The practice of illegal fishing, which remains a common issue in Indonesian territorial waters has made it difficult for Indonesia to realize itself as a maritime nation. Therefore, the author intends to discuss how are the appropriate efforts to eradicate illegal fishing practices in order to create a sovereign Indonesian state. The type of research used is normative juridical. In addition, this research has an analytical descriptive nature. This research concludes that to maximize the eradication of illegal fishing practices in Indonesia is to strengthen its maritime security system. There are two indicators, namely the optimization of maritime security institutions and strengthening legal products in the form of the Maritime Security Law to be able to realize Indonesia as a maritime country.
Tanggung Jawab Penjamin Pada Kredit Macet Dalam Sistem Borgtocht Di Masa Pandemi Covid-19
Authors: Adnan Indra Muchlis , Syahfitri Triyana , Ridwan Muannif
Published: November 2022

This study discusses the legal responsibilities of guarantors for non-performing loans in the borgtocht system during the Covid-19 Pandemic. The research method used is normative juridical. The research concludes that the guarantor's responsibility for non-permorfing loans in banks under the borgtocht system during the Covid-19 Pandemic era is in accordance with Article 1831 of the Civil Code, namely the guarantor is not required to pay the creditor, unless the debtor is negligent, while the debtor's assets must first be confiscated and auctioned to pay off the debt, but the guarantor cannot ask the creditor to confiscate the goods belonging to the debtor first, before the collateral belonging to the guarantor debtor (borg) is confiscated, if the guarantor releases his privileges through a borgtocht deed, it is regulated in Article 1832 of the Civil Code that the guarantor cannot demand that the debtor’s property be confiscated and sold first to pay off his debt if he has waived his privilege to demand that the borrower's property be confiscated/auctioned first. Settlement efforts in the event of non-performing credit involving the guarantor debtor (borg) during the Covid-19 Pandemic include the debtor has the right to apply for credit restructuring if in fact the debtor has defaulted in making debt payments. Other efforts are by peaceful means such as deliberations or negotiations, so that there is no confiscation of the collateral belonging to the guarantor debtor, and the settlement through legal channels is submitted to the Court to be executed on the guarantee and then auctioned off.
Proposed Method of Combining Continuum Mechanics With Einstein Field Equations
Authors: Ogonowski Piotr
Published: November 2022

The article proposes an amendment to the relativistic continuum mechanics which introduces the relationship between density tensors and the curvature of spacetime. The resulting formulation of a symmetric stress-energy tensor for a system with an electromagnetic field, leads to the solution of Einstein Field Equations indicating a relationship between the electromagnetic field tensor and the metric tensor. In this EFE solution, the cosmological constant is related to the invariant of the electromagnetic field tensor, and additional pulls appear, dependent on the vacuum energy contained in the system. In flat Minkowski spacetime, the vanishing four-divergence of the proposed stress-energy tensor expresses relativistic Cauchy's momentum equation, leading to the emergence of force densities which can be developed and parameterized to obtain known interactions. Transformation equations were also obtained between spacetime with fields and forces, and a curved spacetime reproducing the motion resulting from the fields under consideration, which allows for the extension of the solution with new fields.
Условно эйлерово-лагранжев метод на примере задачи о динамике внутритермоклинной вихревой линзы
Authors: Зацепа Сергей Николаевич , Zatsepa Sergei Nikolaevich , Ивченко Александр Александрович , Ivchenko Aleksandr Aleksandrovich , Солбаков Вячеслав Викторович , Solbakov Vyacheslav Viktorovich
Published: November 2022

Разработан новый условно эйлерово-лагранжев численный метод для решения ряда задач, в которых объект исследования сосредоточен в области меняющейся конфигурации, а движение внутри области описывается системой уравнений двумерной сплошной среды. Модификация вычислительной схемы "частиц в ячейках" на адаптивных эйлеровых сетках представлена на примере решения задачи о динамике внутритермоклинной вихревой линзы. Основные уравнения представляют собой уравнения типа "мелкой воды". Область, в которой определяются поля параметров линзы, является искомой и определяется в процессе решения. Проведено исследование искусственной вязкости численной схемы, приведены результаты тестирования метода и примеры вычислительных экспериментов.
Тестовые задачи динамики газовзвесей с использованием асимптотически точных решений
Authors: Садин Дмитрий Викторович , Sadin Dmitrii Viktorovich
Published: November 2022

В предположении малых масштабов динамической и тепловой релаксаций газодисперсной смеси построены асимптотически точные решения задач Римана. В зависимости от параметров состояний газовзвеси по разные стороны от начального произвольного разрыва формируются конфигурации с двумя ударными волнами, волной разрежения и ударной волной, а также двумя волнами разрежения. Для этих тестовых задач проверены вычислительные свойства сбалансированного алгоритма гибридного метода крупных частиц, подходящего для решения жестких задач. Изучены особенности неравновесных волновых течений газовзвеси, а также сходимость численных к асимптотически точным решениям при уменьшении размеров частиц газовзвеси.
Phenotypic manifestations of the CFTR c.3140-16T>A (3272-16T>A) variant in homozygous state in a child with cystic fibrosis
Authors:   Academician E.A.Wagner Perm State Medical University, Perm, Russian Federation, Shadrina V.V. , Melyanovskaya Yu.L. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, Furman E.G. ,   Academician E.A.Wagner Perm State Medical University, Perm, Russian Federation
Published: November 2022

We report a case of cystic fibrosis (CF) in a 9-year-old child with the rare c.3140-16T>A (3272-16T>A) variant of the CFTR gene in homozygous state. CF was suspected at neonatal screening. The results of the sweat test (Nanoduct) were 88 and 84 mmol/L. Since the age of 1.5 months, the patient received inhalation of dornase alfa, kinesitherapy, pancreatic enzymes (only in case of abundant intake of fatty foods), and vitamin therapy. The boy early developed cough with sputum; at the age of 5 years, he also developed chronic sinusitis. At the age of 3 years, his level of fecal pancreatic elastase 1 was 597 μg/g, which indicated preserved exocrine function of the pancreas. At the age of 9 years, the boy demonstrated normal physical development and lung function (examined using spirometry). Computed tomography showed no bronchiectasis. X-ray revealed radiological signs of chronic sinusitis. The assessment of intestinal current measurement (ICM) demonstrated a reduced CFTR function typical of mild genetic variants. Thus, the patient with the c.3140-16T>A (3272-16T>A) variant in homozygous state has developed only chronic rhinosinusitis by the age of 9 years. Measurement of ICM confirmed the diagnosis of mild CF genotype. Key words: c.3140-16T>A (3272-16T>A) genetic variant, cystic fibrosis, mild phenotype
Congenital concomitant pathology of the pancreas: cystic fibrosis, pancreatitis, and diabetes
Authors:   Research Centre for Medical Genetics, Moscow, Russian Federation, Kondratyeva E.I. ,   Research Clinical Institute of Childhood of the Moscow Region, Moscow, Russian Federation, Razumovsky A.Yu. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation,   N.F.Filatov Children’s City Clinical Hospital Nо 13, Moscow Healthcare Department, Moscow, Russian Federation, Smirnov A.N. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation,   N.F.Filatov Children’s City Clinical Hospital Nо 13, Moscow Healthcare Department, Moscow, Russian Federation, Kholostova V.V. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation,   N.F.Filatov Children’s City Clinical Hospital Nо 13, Moscow Healthcare Department, Moscow, Russian Federation
Published: November 2022

In this article, we report a case of cystic fibrosis (CF) with untypical manifestations, including obstructive pancreatitis with relative pancreatic insufficiency, complicated by pancreatolithiasis and type 1 diabetes mellitus (DM1). Interestingly, the patient had almost none clinical manifestations of CF in the lower respiratory tract. The first manifestation was abdominal pain associated with chronic obstructive pancreatitis. The patient had only laboratory manifestations of DM1 without any clinical signs. DM1 treatment led to an increase in the child's body weight and increased external respiration, which allowed an operation for pancreatitis. We removed calculi and performed longitudinal pancreaticojejunostomy. The surgery alleviated pain and increased the external secretion of the pancreas. Thus, this case demonstrates difficulties associated with CF diagnosis, as well as effectiveness and feasibility of surgical treatment for obstructive pancreatitis, even in cases when it is believed to be an inherited and incurable disease. Key words: cystic fibrosis, pancreatitis, pancreatic insufficiency, pancreatolithiasis, type 1 diabetes mellitus
Health status of twins with cystic fibrosis and F508del/R334W genotype: opportunities of targeted therapy
Authors:   Research Centre for Medical Genetics, Moscow, Russian Federation, Kondratyeva E.I. ,   Research Clinical Institute of Childhood of the Moscow Region, Moscow, Russian Federation, Voronkova A.Yu. ,   Research Centre for Medical Genetics, Moscow, Russian Federation,   Research Clinical Institute of Childhood of the Moscow Region, Moscow, Russian Federation, Efremova A.S. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, Melyanovskaya Yu.L. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, Bulatenko N.V. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, Bukharova T.B. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, Odinaeva N.D. ,   Research Clinical Institute of Childhood of the Moscow Region, Moscow, Russian Federation, de Jonge H.R. ,   Department of Gastroenterology and Hepatology, Erasmus MC Clinic, Rotterdam, The Netherlands, Goldshtein D.V. ,   Research Centre for Medical Genetics, Moscow, Russian Federation
Published: November 2022

The CFTR gene contains 27 exons and is located at position 31.1 of the long arm of chromosome 7 (7q31.1). More than 2000 variants of the CFTR gene have been described so far. The R334W variant is associated with the mild disease course. Objective. To perform comprehensive assessment of the health status, functional CFTR activity, and efficacy of CFTR modulators in twins with the F508del/R334W genotype. Materials and methods. Data from medical records, intestinal current measurement (ICM), intestinal organoid culture. Results. We examined two twins with moderate cystic fibrosis who had similar clinical manifestations, including rhinosinusitis with nasal polyps and respiratory infections caused by gram-negative bacteria. Both patients also had polyvalent allergy. One child presented with a decrease of pancreatic elastase 1 in stool from 500 μg/g to 125 500 μg/g, which required administration of pancreatin and dosage increase later. Both children had reduced chloride channel function as demonstrated by ICM. The administration of a corrector (VX-809) and a potentiator (VX-770) effectively restored the channel function; their simultaneous use ensured an additive effect. The quantitative results obtained in both cultures of intestinal organoids were very similar. Key words: cystic fibrosis, CFTR gene, pathogenic variant R334W, intestinal current measurement, intestinal organoids, forskolin-induced swelling assay, correctors, potentiators, targeted therapy, ivacaftor, lumacaftor
Selection of CFTR modulators for children with the W1282R variant
Authors:   Research Centre for Medical Genetics, Moscow, Russian Federation, Voronkova A.Yu. , N.V.Bulatenko N.V. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, Yu.L.Melyanovskaya Yu.L. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, A.S.Efremova A.S. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, T.B.Bukharova T.B. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, S.I.Kutsev S.I. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, H.R. de Jonge H.R. ,   Department of Gastroenterology and Hepatology, Erasmus MC Clinic, Rotterdam, The Netherlands, N.V.Petrova N.V. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, D.V.Goldshtein D.V. ,   Research Centre for Medical Genetics, Moscow, Russian Federation
Published: November 2022

Objective. To study the clinical manifestations of W1282R variant, functional activity of the cystic fibrosis transmembrane conductance regulator (CFTR) channel, and effectiveness of CFTR modulator therapy in patients with the W1282R variant. Materials and methods included medical records, intestinal current measurement method (ICM) and method of intestinal organoids (IO). Results. The c.3844T>C (p.Trp1282Arg, W1282R) variant refers to missense mutations. The Cystic Fibrosis (CF) Patient Registry of the Russian Federation (2019) provides the data on 34 patients with the W1282R variant in the genotype. Clinical manifestations in two patients with the W1282R variant corresponds to the severe course of CF. ICM method revealed the loss of CFTR function. The effect of VX-809 corrector, VX-770 potentiator and their combined use were assessed in each patient using the method of IO. Conclusion. The results indicated a “severe” W1282R variant. The application of VX-809 corrector had no effect on the restoration of chloride channel function, unlike the F508del homozygous control sample (class II mutations). The VX-770 potentiator had no effect on the kinetic properties of CFTR protein. But in both patients, a significant restoration of lost channel function (~45%) was recorded with the combined use of VX-809 corrector and VX-770 potentiator, which is typical for class III and class IV variants. This challenges the conclusions that the W1282R variant has class II characteristics only. Combination therapy with VX-809 and VX-770 may be recommended for patients with the W1282R/CFTRdel2,3 and W1282R/F508del genotypes. Key words: cystic fibrosis, CFTR gene, W1282R pathogenic variant, intestinal current measurement method, intestinal organoids, forskolin-induced swelling assay, correctors, potentiators, target therapy, ivacaftor, lumacaftor
The Role of Database Applications of Digital Archive Management in The Era of Society 5.0
Authors: Marsofiyati  , Eryanto Henry , Usman Osly , Faslah Roni , Febriantina Susan , Oktobisono Anggriawan , Fadli Ghifari Aminudin , Sulastri Tita , Suparman Ady Fahril , Nada Shafwatun , Maharrizki Alif
Published: November 2022

We will encounter many technologies in the 4.0 revolution era, such as cloud computing, artificial intelligence, the internet, 5G, digitalization, and big data. All of these technologies have potential in the world of education. Based on information about some of the problems faced by teachers at ASPAPI Member Vocational Schools in the DKI Jakarta area, they must be addressed as soon as possible as a solution to increasing knowledge, abilities, and skills in running database applications on digital archives as one of the development and utilization of information and communication technology in the Industrial Revolution 4.0 era and the 5.0 social era. Therefore, the community service team tries to offer solutions to these problems through the following main activities: 1) increasing the understanding and skills of ASPAPI Member Vocational High School teachers in the DKI Jakarta area, 2) increasing abilities in teaching and learning activities for digital archives, especially the use of database applications. The method used for providing training consists of planning, action execution, observation, and reflection. We generate an application called Dive Apps, where these apps can manage archives with a digitalization system and can also be used by teachers in archival learning.
Rapid Community Engagement in Response to SARS-CoV-2 Funding Opportunities: New York City, 2020‒2021
Authors: Williams Natasha J. , Gill Emily , Punter Malcolm A. , Reiss Jeremy , Goodman Melody , Shelley Donna , Thorpe Lorna E.
Published: November 2022

In response to fast-turnaround funding opportunities, collaborations have been forming across the country to address severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disparities. Here we describe the process, notes from the field, and evaluation results from a new collaboration involving multiple partners, formed in October 2020 in New York City as part of the Rapid Acceleration of Diagnostics initiative. We used the validated Research Engagement Survey Tool to evaluate the partnership. Results can inform future research and improve engagement efforts aimed at reducing SARS-CoV-2 disparities. (Am J Public Health. 2022;112(S9):S904–S908. https://doi.org/10.2105/AJPH.2022.307072 )
Effects of a Health Education Intervention for COVID-19 Prevention in Latinx Communities: A Cluster-Randomized Controlled Trial
Authors: De Anda Stephanie , Budd Elizabeth L. , Halvorson Sven , Mauricio Anne Marie , McWhirter Ellen Hawley , Cioffi Camille C. , Ramírez García Jorge I. , Cresko William A. , Leve Leslie D. , DeGarmo David S.
Published: November 2022

To promote COVID-19 preventive attitudes and behaviors among Latinx individuals, researchers and community partners implemented a culturally tailored health education intervention across 12 Oregon counties from February 2021 through April 2022. We did not identify any significant intervention effects on preventive attitudes and behaviors but did observe significant decreases in psychological distress. Although Latinx individuals’ preventive attitudes and behaviors were not associated with the health education intervention, findings suggest the intervention has value in promoting their well-being (ClinicalTrials.gov Identifier: NCT04793464). (Am J Public Health. 2022;112(S9):S923–S927. https://doi.org/10.2105/AJPH.2022.307129 )
National Ordinary High Water Mark Field Delineation Manual for Rivers and Streams : Interim Version
Authors: David Gabrielle C. L. , Trier Patrick H. , Fritz Ken M. , Kichefski Steven L. , Nadeau Tracie-Lynn , James L. Allan , Topping Brian J. , Ellen E. Wohl , Allen Aaron
Published: November 2022

The ordinary high water mark (OHWM) defines the lateral extent of nontidal aquatic features in the absence of adjacent wetlands in the United States. The federal regulatory definition of the OHWM, 33 CFR 328.3(c)(7), states the OHWM is “that line on the shore established by the fluctuations of water and indicated by physical characteristics such as [a] clear, natural line impressed on the bank, shelving, changes in the character of soil, destruction of terrestrial vegetation, the presence of litter and debris, or other appropriate means that consider the characteristics of the surrounding areas.” This is the first manual to present a methodology for nationwide identification and delineation of the OHWM. A two-page data sheet and field procedure outline a weight-of-evidence (WoE) methodology to organize and evaluate observations at stream sites. This manual presents a consistent, science-based method for delineating the OHWM in streams. It also describes regional differences and challenges in identifying the OHWM at sites disturbed by human-induced or natural changes and illustrates how to use remote data to structure field inquiries and interpret field evidence using the principles of fluvial science. The manual demonstrates that, in many landscape settings, the OHWM may be located near the bankfull elevation.
Usabilidad de Moodle para apoyar clases presenciales : un estudio sobre las percepciones de profesores y estudiantes de la Universidad de La Salle
Authors: Aguilar-Cortés Carlos Eduardo , Rojas-Rodríguez Jorge Edison , Betancur-Chicué Viviana , López-Ospina Liz Stefany
Published: November 2022

Este artículo presenta el análisis realizado sobre la usabilidad de Moodle como plataforma de apoyo a las clases presenciales en la Universidad de La Salle, Bogotá. Aunque Moodle se ha convertido en una plataforma digital con preponderancia en la educación superior con TIC, esta investigación se propuso validar su efectividad, eficiencia y satisfacción como Learning Management System (LMS) desde las percepciones de sus usuarios, según sus propósitos de enseñanza y aprendizaje. El proceso investigativo se realizó teniendo en cuenta los aportes de una muestra significativa de profesores y estudiantes que participaron en clases presenciales con apoyo de aulas virtuales de Moodle. Si bien el estudio se centró en la experiencia previa al COVID-19, se presentan datos informados por esta contingencia sanitaria. El análisis se desarrolló utilizando un enfoque mixto, a través de una investigación con encuestas virtuales, preguntas de respuesta de tipo cerrado y abierto, e instrumentos diferentes para estudiantes y profesores, de los cuales se derivaron datos de carácter cualitativo y cuantitativo. Las principales conclusiones sugieren que los profesores y estudiantes manifestaron una percepción positiva sobre la usabilidad general de Moodle para apoyar clases presenciales, así como de la mayoría de las herramientas que ofrece esta plataforma. No obstante, si bien se reconoció en Moodle un sistema de gestión de aprendizaje pertinente para enriquecer las clases presenciales de la universidad, se encontró que, para acrecentar su usabilidad b-learning, es necesario trabajar con docentes y estudiantes en el entrenamiento de algunos de sus componentes.
Guest Editorial: UPSKILLING in a Lean Working Environment
Authors: Lougheed Dylan
Published: November 2022

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A pervasive shortage of technical skills is costing the energy  sector billions of dollars every year in lost value. One  global oil and gas recruiting firm estimated last year that  41% of this skills shortage is due to lack of adequate education and training.

So, why are operators struggling so much to acquire and retain a skilled workforce? There are several reasons, but two in particular stand out to us since they have recently emerged within the continuing education landscape.

1. The significant—and likely permanent—headcount reduction resulting from the pandemic.

2. Conditions where technical skill requirements are rapidly evolving due to the clean energy transition and net-zero initiative.

The combination of these two new and indisputable realities has created an environment wherein, if left unchecked, the skills gap will almost certainly get worse.

A seemingly obvious solution to the skills gap problem would be for energy companies to ramp up their investment in skill development and training. But this ignores the constraints energy producers currently face.

For instance, despite current favorable economic conditions, investors remain supportive of the producers’ focus on increasing return on capital vs. increasing their general and administrative (G&A) budget.

In addition to the pressure to drive cashflow, a more pressing constraint is time. When I ask upstream professionals whether they feel they are doing enough to upskill in their career, most say no. The reason is usually time, or lack thereof.

Today’s positive economics combined with lean operations mean that time for training is extremely limited.

Avenues for Learning

Suppose the above conditions don’t change.

Suppose we will continue to run lean as an industry, and as a result, time and budget for training will always be a problem. What can we do as an industry to reduce the skills gap? What are the available avenues for upskilling?

The baseline option is to do nothing. In other words, we can learn by doing.

To its credit, a great deal of technological advancement has resulted from this approach. The advantage of doing nothing is that learning will always take place on the job.

It could be argued that this is also an efficient option since the learnings from the work are directly applicable to the work. However, this “do nothing” approach carries both cost and risk. Risk comes in the form of mistakes that could have been avoided with proper training.

The associated costs can be high and include drilling into a depleted zone or a botched completion. The industry has many examples to draw on where neglecting knowledge- and experience-sharing has proven to be enormously inefficient and costly.

An alternative is to insource all training. This is considered to be a low-cost avenue since it relies on using subject matter experts already within the company to teach other employees. Hence, existing stores of wisdom and company best practices can be disseminated with no additional investment.
Data Analytics Study Clarifies Parent/Child Well Relationships in Unconventional Basins
Authors: Carpenter Chris
Published: November 2022

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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 209171, “Parent/Child Well Relationships Across US Unconventional Basins: Learnings From A Data Analytics Study,” by Joe Cozby, SPE, EOG Resources, and Mukul M. Sharma, SPE, The University of Texas at Austin. The paper has not been peer reviewed.

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In this study, parent/child well pairs for wells completed within the last 7 years in nine different unconventional basins are identified using a Python code applied to public data. These basins are the Bakken, Delaware, Eagle Ford, Haynesville, Marcellus/Utica, Midland, Niobrara, Powder River, and Scoop/Stack Basins. The study finds that, as stated in the technical literature, child-well performance increases with spacing and decreases with infill timing. In the complete paper, the authors show that parent cumulative production [barrel of oil equivalent (BOE)] at the child-well completion is a better indicator of child-well performance.

Challenges of Child Wells

Many different factors influence the completion and production of a child well. An engineer’s role is to determine the optimal way to complete infill wells to mitigate those risks, namely depletion and fracture communication, and maintain economic efficiencies. This section of the complete paper provides a high-level overview of the primary problems that cause child wells’ reduced production performance, including depletion and fracture communication.

Current Public Production Analysis

The data analysis conducted in this study was inspired primarily by the work of two previous studies outlined in the complete paper.

Both groups of researchers took a high-level approach to analyzing and characterizing various unconventional basins by aggregating all parent/child well pairs within each basin for analysis. The authors of this paper detail the methodology and results used by these studies to allow the reader an appreciation of the methodological changes and assumptions adopted in their own study.
Integrated Completion Design Method Predicts Sand Production
Authors: Carpenter Chris
Published: November 2022

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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 205935, “From Wellbore Breakout to Sand-Production Prediction: An Integrated Sand-Control Completion Design Methodology and Case Study,” by Caleb DeValve, Gilbert Kao, SPE, and Stephen Morgan, ExxonMobil, et al. The paper has not been peer reviewed.

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This paper presents a physics-based approach to predicting sand production on a well-by-well basis to inform overall sand-management design. The work flow integrates geomechanical estimates of wellbore breakout and volume of failed sand downhole, log-based prediction of the sand-particle-size variation along the well path, modeling of sand filtration based on experimental and analytical methods for specific completion options, and a natural sandpack-permeability prediction for standalone screen (SAS) completions and associated well-performance analysis.

Method

The general challenge addressed in this paper is how to predict the produced sand mass rate from any given well with a specific sand-control completion installed. A novel four-step method has been created to predict sand production from wells drilled in hydrocarbon-bearing sandstone formations with installed sand-control equipment and its associated effect on well productivity (Fig. 1).

This process improves the traditional sand-control completion design process, which relies on limited formation data obtained through coring programs and classified according to particle-size distribution (PSD) characteristics (D10, fines content, and uniformity coefficient). PSD is critical data for traditional sand-control analysis, and multiple cores are used to represent the varying rock characteristics expected throughout a reservoir. The selection of sand control and the ultimate completion design using existing work flows will be based on the range of PSDs measured from the core study, along with their predicted distribution along the drilled well paths based on practitioner experience. The novel work flow presented in this paper enhances the traditional approach by integrating geomechanical failed sand volume (FSV) predictions with sand-screen-filtration performance expectations, which are analyzed along the wellbore to improve overall completion selection. These results can be integrated with traditional well-performance simulation to understand completion performance and influence well startup.
The Impact of Green Chelating Agent and Corrosion Inhibitor on Foam Rheology and Stability at High Temperature, Pressure, and Salinity
Authors: Al-Darweesh Jawad , Aljawad Murtada Saleh , Al-Yousif Zuhair , BinGhanim Ahmed , Kamal Muhammad Shahzad , Mahmoud Mohamed
Published: November 2022

This research fills the gap in understanding the impact of corrosion inhibitors (CIs) and a chelating agent on the rheology and stability of foam under harsh conditions. In this regard, a modified high-pressure, high-temperature (HPHT) foam rheometer and HPHT foam analyzer were used to investigate foam rheology and stability at 1,000 psi and 120 to 150°C with carbon dioxide (CO2) in the gas phase. Surfactant screening showed that Duomeen TTM and Armovis are thermally stable at high temperature and high water salinity and thus were used in this study. The liquid phase generally contained produced water (PW) (total dissolved solids ~ 24,611 ppm), 15 wt% chelating agent [L-glutamic acid-N, N-diacetic acid (GLDA)], and 1 wt% surfactant with and without a CI. First, we screened the viscosity and stability of Duomeen TTM and Armovis; the results showed that Duomeen TTM has a higher viscosity (at least by 82%) at a low shear rate, but both have similar viscosity at a higher shear rate. However, Armovis produced more stable foam. Once the GLDA was added to the Duomeen TTM solution, the viscosity increased significantly by 135% at a high shear rate (1,000–1,500). For the Armovis system, the viscosity improved by 77% and 68% at the low and high shear rates by adding GLDA. Additionally, foam stability was improved remarkably in both systems; half-life time almost doubled. Finally, we reported the effect of CI on the fluid systems, showing it considerably reduced the foam viscosity and stability. It reduced the half-life of the Armovis system by 79.4% and hindered the generation of foam for the Duomeen TTM system. A detailed discussion of foam properties, such as foamability, bubble count, and bubble radius, is provided. This study provides a wide-ranging understanding of additives’ impact on stimulating foam stability at HPHT.
BrkgaCuda 2.0: A Framework for Fast Biased Random-Key Genetic Algorithms on GPUs
Authors: de Oliveira Bruno Almêda , Xavier Eduardo Candido , Borin Edson
Published: November 2022

In this paper, we present the development of a new version of the BrkgaCuda, called BrkgaCuda 2.0, to support the design and execution of Biased Random-Key Genetic Algorithms (BRKGA) on CUDA/GPU-enabled computing platforms, employing new techniques to accelerate the execution. We compare the performance of our implementation against the standard CPU implementation called BrkgaAPI, developed by Toso and Resende (2015), and the recently proposed GPU-BRKGA, developed by Alves et al (2021). In the same spirit of the standard implementation, all central aspects of the BRKGA logic are dealt with our framework, and little effort is required to reuse the framework on another problem. The user is also allowed to choose to implement the decoder on the CPU in C++ or on GPU in CUDA. Moreover, the BrkgaCuda provides a decoder that receives a permutation created by sorting the indices of the chromosomes using the genes as keys. To evaluate our framework, we use a total of 54 instances of the Traveling Salesman Problem (TSP), the Set Cover Problem (SCP), and the Capacitated Vehicle Routing Problem (CVRP), using a greedy and an optimal decoder on the CVRP. We show that our framework is faster than the standard BrkgaAPI and the GPU-BRKGA while keeping the same solution quality. Also, when using the bb-segsort to create the permutations, our framework achieves even higher speedups when compared to the others.
Deterministic Bell state measurement with a single quantum memory
Authors: Kosaka Hideo , Kamimaki Akira , Wakamatsu Keidai , Mikata Kosuke , Sekiguchi Yuhei
Published: November 2022

Any quantum information system operates with entanglement as a resource, which should be deterministically generated by a joint measurement known as complete Bell state measurement (BSM). The determinism arises from a quantum nondemolition measurement of two coupled qubits with the help of readout ancilla, which inevitably requires extra physical qubits. We here demonstrate a deterministic and complete BSM with only a nitrogen atom in a nitrogen-vacancy (NV) center in diamond as a quantum memory without reliance on any carbon isotopes by exploiting electron‒nitrogen (14N) double qutrits at a zero magnetic field. The degenerate logical qubits within the subspace of qutrits on the electron and nitrogen spins are holonomically controlled by arbitrarily polarized microwave and radiofrequency pulses via zero-field-split states as the ancilla, enabling the complete BSM deterministically. Since the system works under an isotope-free and field-free environment, the demonstration paves the way for realizing high-yield, high-fidelity, and high-speed quantum repeaters for long-haul quantum networks and quantum interfaces for large-scale distributed quantum computers.
MicroRNAs-26 and related osteogenic target genes can play a pivotal role in improving the mechanical and cellular properties of critical-sized foot defects in photobiomodulation and adipose-derived stem cell-based treatments in a rat model
Authors: Mohebbi Hanieh , Torbati Elham Siasi , Khosravipour Armin , Asghari Mohammadali , Amini Abdollah , Mostafavinia Atarodalsadat , Bayat Mohammad
Published: November 2022

Photobiomodulation (PBM) and stem cell-based treatments are relatively invasive methods for treating bone defects. Specific and oriented cellular and molecular functions can be induced by applying an appropriate type of PBMT and ADSs. This study aimed to explore the role of MicroRNAs in the PBM & hADS-based treatments in improving the mechanical and cellular properties of a critical size fracture in a rat model. A critical size femoral defect (CSFD) is induced in both femoral bones of 24 rats. Then a human demineralized bone matrix scaffold (hDBMS) was engrafted into the CSFDs of all rats. Experiments are performed on 4 groups (12 rats per group): (1) Control (hDBMS); (2) hDBMS + hADS, hADS was engrafted into CSFDs; (3) hDBMS + PBM, the CSFD was exposed to PBM(810 nm wavelength, 1.2 J/cm2 energy density); (4) hDBMS+(hADS + PBM), hADSs were implanted into CSFD then were exposed to PBM. At 42 days after CSFD induction, the rats were killed and, the left and right CSFDs were removed for the mechanical compression tests, and molecular and cellular studies, respectively. The results indicate that miRNA-26a, BMP, SMAD, RUNX, and OSTREX were more expressed in the treated groups than in the control group. Furthermore, the biomechanical and histological properties of CSFDs in treated groups were better than the control group. The correlation tests revealed a positive relationship between microRNA and improving biomechanical and cellular parameters of CSFDs in the rat model. We concluded that MicroRNA-26 plays a significant role in the hADS, PBM, and hADS + PBM-based healing of CSFDs in rats.
Investigating the impact of innovation on Carbon emission: Evidence from OBOR countries
Authors: Mpeqa Rethabile , Sun Hua Ping , Beraud Jean-Jacques Dominique
Published: November 2022

Carbon dioxide emissions are a major cause of global climate change. The public is aware that the world must rapidly reduce its windows to avoid the worst effects of climate change. But how this responsibility is distributed between regions, countries, and individuals has become a recurring element of debate in international debates. This study aimed to compare the different impacts of exporting and importing CO2 emissions in 29 selected countries with the Belt and Road Initiative from 2008 to 2019. We will also look at the impact of innovations on CO2 emissions. Regular testing is done using cross-sectional data, panel data, and integrated testing. Sector results show that exports and imports have a negative effect on CO2 emissions.. EKC is useful in these countries. In addition, population size and energy efficiency increase CO2 emissions. Modern technologies reduce CO2 emissions by increasing energy efficiency. It is important to promote environmental sustainability and the development of professional enterprises in certain countries.
A Randomised Controlled Trial evaluating the Guide Cymru Mental Health Literacy intervention programme in Year 9 (age 13-14) school pupils in Wales
Authors: Simkiss Nicola J. , Gray Nicola S. , Kemp Andrew , Dunne Chris , Snowden Robert J.
Published: November 2022

Background
Adolescent mental health has become a public health concern as 10–20% of adolescents have experiences with mental health problems. Improving mental health education is critical to reducing stigma and improving access to appropriate care when needed. Here we examine the impact of a mental health literacy programme (Guide Cymru) in young adolescents in the UK. A randomised controlled trial assessed the effectiveness of the Guide Cymru intervention.
Method
A total of 1,926 pupils (860 males and 1066 females) aged 13–14 (year 9) took part in the study. The secondary schools were randomised into the active and control arms of the study. Teachers in the active arm of the study were trained on the Guide Cymru and then delivered the intervention to their pupils. Pupils in the active groups received six modules of mental health literacy (the Guide Cymru), and control schools received teaching as usual. Mental health literacy across several domains (e.g., knowledge, stigma, help-seeking intentions) were assessed both before and after the intervention. Data collection for the randomised controlled trial ran from September 2019 to March 2020. Multi-level modelling analysis was conducted to account for the clustered nature of the design.
Results
All aspects of mental health literacy, including mental health knowledge (g = 0.32), good mental health behaviours (g = 0.22), mental health stigmas (g = 0.16), intentions to seek help (g = 0.15), and avoidant coping (g = 0.14) improved after completing the Guide Cymru programme (ps < .001).
Discussion
The current study presents evidence for the Guide Cymru’s effectiveness in improving secondary school pupils' mental health literacy. We demonstrate that providing teachers with appropriate resources and training to deliver the Guide Cymru programme within their classrooms can improve the mental health literacy of pupils. These findings have important implications for the beneficial impacts the secondary school system can have on reducing the burden of mental health problems at a critical point in a young person’s life.
Trial registration
ISRCTN15462041. Registered 03/10/2019.
Angioarchitecture and genetic variants of spinal cord cavernous malformations and associated DVAs — A case report
Authors: Ren Jian , Tu Tianqi , Hong Tao , Zhang Hongqi
Published: November 2022

Cavernous malformations (CMs) have long been considered congenital of central nervous system, while the mechanism of CMs detailed development process associated with genetic factors remains unclear. We reported an uncommon case which suffered spinal cord cavernous malformations. In this work, representative samples were obtained and the sequenced results were described for the first time. A 9-year-old boy was found oblique shoulder with slightly weakness of left limbs, MRI indicated spinal cord cavernous malformations (CMs) located at the C4-C6 vertebral level. On genetic analysis, a shared mutation of PIK3CA (p.H1047R) in CMs and associated DVAs was detected, with a different abundance (2% and 7%, respectively), and a somatic mutation of MAP3K3 (p.I441M) was detected in the CM tissue samples. This case provides better knowledge of the formation history and genetic triggers of the DVA-associated CMs. This evidence allows us to speculate the developmental history of the CM lesion: the DVA with PIK3CA mutation might be genetic precursor, and then the associated CM could be derived from terminal cell population of the DVA by acquiring a somatic mutation in MAP3K3.
Melatonin alleviates chromium toxicity by altering Cr6+ subcellular distribution and enhancing antioxidant metabolism in wheat seedlings
Authors: Sun chuanjiao , Gao Lijun , Xu Libin , Zheng Qiaomei , Sun Shuzhen , Liu Xiaoxue , Zhang Zigang , Tian Zhongwei , Dai Tingbo , Sun Jianyun
Published: November 2022

It was reported that Melatonin (MT) is essential for plants and can mitigate multiple abiotic stresses. However, the mechanism used by endogenous MT to alleviate chromium phytotoxicity is still unclear. In this study, the effects of MT pretreatment on growth, root architecture, subcellular Cr distribution, phytochelatin synthesis and antioxidant metabolism of wheat seedlings under chromium (50 µM Cr6+) stress were researched. Our results showed that Cr stress markedly inhibited seedlings growth and increased ROS accumulation in both roots and leaves. Importantly, growth inhibition and oxidative stress were significantly improved by MT under Cr stress. On the one hand, Cr accumulation and transport from roots to leaves were reduce by MT, which was owed to enhanced vacuolar sequestration via up-regulated phytochelatin (PC) accumulation, which was derived from that MT up-regulated the expression of key genes for PC synthesis (TaPCS and Taγ-ECS). On the other hand, MT pretreatment obviously alleviated Cr-induced oxidative damage, which proved by the diminished lipid peroxidation and cell apoptosis, profiting from the enhanced scavenging ability of reactive oxygen species (ROS) as a result of the MT-induced increment of the activities of superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX) and glutathione reductase (GR) and the related encoding genes expression levels of TaSOD2, TaCAT, TaAPX and TaGR. Taken together, all these results revealed that MT alleviated Cr toxicity to wheat seedlings probably through altering Cr6+ subcellular distribution and enhancing antioxidant metabolism. And these findings may be helpful to increase wheat production under Cr stress.
TMT-based proteomic analysis of the causes of reduced seed viability in Allium mongolicum under accelerated aging
Authors: Song Xiaoqing , Zhang Dong , Zhang Fenglan , Zhang Xiaoyan , Liu Jiecai , Yang Zhongren
Published: November 2022

Background: Seeds are the most basic production material in agricultural production and occupy an important position in the whole process of agricultural production. However, aging begins to occur after seed harvested, serious aging will affect the conservation of germplasm resources. Seed propagation is the most commonly used method in the production of A.mongolicumseeds, but with the prolongation of storage time, A.mongolicum seeds undergo different degrees of aging. Therefore, we used an integrated approach of Tandem Mass Tag(TMT) labeling in conjunction with liquid chromatographytandem mass spectrometry (LC-MS/MS) to capture the differential protein expression profiles of A.mongolicumseeds under unaged (CK), lightly aged (T1), and severely aged (T4) treatments to provide evidence of protein expression levels for revealing the aging mechanism study of A.mongolicumseeds.
Results: A total of 4336 proteins were identified in this study, of which 4318 total proteins could be quantified. There were 291 diferentially expressed proteins (DEPs) identifed after accelerated aging treatments. Compared with CK, 36 DEPs (16 up-regulated and 20 down-regulated) were found in T1; and 139 DEPs (64 up-regulated and 75 down-regulated) in T4. Compared with T1, 116 DEPs (51 up-regulated and 65 down-regulated) were found in T4. A number of candidate proteins associated with seed aging were screened, for example, ATP-dependent RNA helicase-like protein DB10(Unigene0060546)、β-D-glucan exohydolase(Unigene0008772)、Histone H1.2 partial(Unigene0049278)、defensin Ec-AMP-D2(Unigene0042879)、NAD(P)H dehydrogenase (quinone) FQR1(Unigene0047137)、glutathione S-transferase(Unigene0000863)、oleosin S1-2(Unigene0011542)、probable inactive purple acid phosphatase 2(Unigene0010352)、glutathione S-transferase U8-like(Unigene0006910)、glutathione S-transferase U17-like(Unigene0051938).
Conclusions: This study was the first to determine the proteome of A.mongolicum seeds, these data provided references for further study of seed aging mechanism of A.mongolicum. The results showed that the related proteins were significantly enriched in glutathione metabolism and other pathways after accelerated aging. In addition, among the candidate proteins, PAP2 is down-regulated after aging, which was speculated to be the main reason for limiting radicle growth.