bluuebunny/crossref_metadata_2025 huggingface dataset:
Direct optical patterning of perovskite nanocrystals with ligand cross-linkers
Authors: Liu Dan , Weng Kangkang , Lu Shaoyong , Li Fu , Abudukeremu Hannikezi , Zhang Lipeng , Yang Yuchen , Hou Junyang , Qiu Hengwei , Fu Zhong , Luo Xiyu , Duan Lian , Zhang Youyu , Zhang Hao , Li Jinghong
Published: March 2022

Precise microscale patterning is a prerequisite to incorporate the emerging colloidal metal halide perovskite nanocrystals into advanced, integrated optoelectronic platforms for widespread technological applications. Current patterning methods suffer from some combination of limitations in patterning quality, versatility, and compatibility with the workflows of device fabrication. This work introduces the direct optical patterning of perovskite nanocrystals with ligand cross-linkers or DOPPLCER. The underlying, nonspecific cross-linking chemistry involved in DOPPLCER supports high-resolution, multicolored patterning of a broad scope of perovskite nanocrystals with their native ligands. Patterned nanocrystal films show photoluminescence (after postpatterning surface treatment), electroluminescence, and photoconductivity on par with those of conventional nonpatterned films. Prototype, pixelated light-emitting diodes show peak external quantum efficiency of 6.8% and luminance over 20,000 cd m
−2
. Both are among the highest for patterned perovskite nanocrystal devices. These results create new possibilities in the system-level integration of perovskite nanomaterials and advance their applications in various optoelectronic and photonic platforms.
Bacterial Carboxyl-Terminal Processing Proteases Play Critical Roles in the Cell Envelope and Beyond
Authors: Sommerfield Alexis G. , Darwin Andrew J.
Published: March 2022

Proteolysis is essential throughout life, and as more proteases are characterized, our understanding of the roles they play continues to expand. Among other things, proteases are critical for protein turnover and quality control, the activation or inactivation of some enzymes, and they are integral components of signal transduction pathways.
Sequential Phosphorylation of Hepatitis C Virus NS5A Protein Requires the ATP-Binding Domain of NS3 Helicase
Authors: Yu Chun-Chiao , Lin Pei-Chen , Chiang Cho-Han , Jen Shu-Tang , Lai Yen-Ling , Hsu Shih-Chin , Lo Lee-Chiang , Lin Jing-Jer , Chan Nei-Li , Yu Ming-Jiun
Published: March 2022

For more than 20 years, NS3 was known to participate in NS5A sequential phosphorylation. In the present study, we show for the first time that the ATP-binding domain of NS3 is involved in NS5A phosphorylation.
In vitro
assays showed that casein kinase Iα is a very potent kinase responsible for NS5A phosphorylation at serines 225, 232, and 235.
When Poly(A) Binding Proteins Meet Viral Infections, Including SARS-CoV-2
Authors: Gao Jie , Tang Yan-Dong , Hu Wei , Zheng Chunfu
Published: March 2022

Viruses have evolved diverse strategies to hijack the cellular gene expression system for their replication. The poly(A) binding proteins (PABPs), a family of critical gene expression factors, are viruses’ common targets.
The Nonmonotonic Dose Dependence of Protein Expression in Cells Transfected with Self-Amplifying RNA
Authors: Tanimoto Cheylene R. , Thurm Abby R. , Brandt Devin S. , Knobler Charles M. , Gelbart William M.
Published: March 2022

Positive-sense RNA viruses often have a cytotoxic effect on their host cell because of the strength of their RNA replicase proteins, even though only one copy of their genome begins the viral life cycle in each cell. Noninfectious forms of them—replicons—which include just their RNA replication-related genes, are also strongly self-amplifying and cytotoxic.
Late Mesozoic intracontinental deformation and magmatism in the Chinese Tianshan and adjacent areas, Central Asia
Authors: Wang Fujun , Luo Meng , He Zhiyuan , Ge Rongfeng , Cao Yuanyuan , Grave Johan De , Zhu Wenbin
Published: March 2022

The Tianshan Range–Junggar Basin– Kalamaili Range system represents the southwestern Central Asian Orogenic Belt and is a natural laboratory for studying intracontinental deformation processes. Its current topography is a product of the farfield effects of the Cenozoic India-Asia collision. However, the Mesozoic topographic and tectonic evolution of the Tianshan and Kalamaili Ranges and their impacts on the Junggar Basin remain enigmatic due to the scarcity of data. Here, we present a comprehensive synthesis of sedimentological and geochronological data on these ranges and adjacent basins to reconstruct the intracontinental evolution from the Early Jurassic to the Early Cretaceous. Based on field observations and seismic profile analysis, we identified several unconformities within the late Mesozoic strata in the Tianshan Range and the Junggar Basin. Detrital zircon U-Pb dating results for Lower Jurassic to Lower Cretaceous sandstones of the eastern and southern Junggar Basin, with published paleocurrent data, reveal a complex intracontinental topographic evolution. Moreover, tuffaceous gravels and tuff samples yielded weighted mean zircon 206Pb/238U ages of 156.5 ± 3.2 Ma and 156.3 ± 2.2 Ma, respectively, which indicates the presence of contemporary magmatic activity. The deformation and magmatism mentioned above were possibly related to multi-plate convergence in East Asia during the late Mesozoic. This study provides new insights into the late Mesozoic tectonic-magmatic evolution of the Tianshan Range and its adjacent areas.
Oral irritation fibroma associated with the pathological migration of a primary tooth
Authors: Lapitskaya Anastasiya , Cahuana-Bartra Pau , Brunet-Llobet Lluís , Miranda-Rius Jaume
Published: March 2022

We report the case of a 3-year-old girl referred to our hospital dentistry service, from a public health centre, due to a 4-week-old swelling in the area of the hard palate, causing displacement of the deciduous tooth and the appearance of an interincisal diastema. The clinical characteristics suggested the possibility of a reactive fibroma and we decided to intervene surgically by means of an excisional biopsy. Histology confirmed the presumptive diagnosis. Prompt referral and early surgical care spontaneously favoured both repositioning of the displaced primary tooth and closure of the diastema. This is an infrequent lesion in paediatric patients.
To call or not to call: exploring the validity of telephone interviews to derive maternal self-reports of experiences with facility childbirth care in northern Nigeria
Authors: Umar Nasir , Schellenberg Joanna , Hill Zelee , Bhattacharya Antoinette Alas , Muzigaba Moise , Tunçalp Özge , Sambo Nuraddeen Umar , Shuaibu Abdulrahman , Marchant Tanya
Published: March 2022

Background

To institutionalise respectful maternity care, frequent data on the experience of childbirth care is needed by health facility staff and managers. Telephone interviews have been proposed as a low-cost alternative to derive timely and actionable maternal self-reports of experience of care. However, evidence on the validity of telephone interviews for this purpose is limited.

Methods

Eight indicators of positive maternity care experience and 18 indicators of negative maternity care experience were investigated. We compared the responses from exit interviews with women about their childbirth care experience (reference standard) to follow-up telephone interviews with the same women 14 months after childbirth. We calculated individual-level validity metrics including, agreement, sensitivity, specificity, area under the receiver operating characteristic curve (AUC). We compared the characteristics of women included in the telephone follow-up interviews to those from the exit interviews.

Results

Demographic characteristics were similar between the original exit interview group (n=388) and those subsequently reached for telephone interview (n=294). Seven of the eight positive maternity care experience indicators had reported prevalence higher than 50% at both exit and telephone interviews. For these indicators, agreement between the exit and the telephone interviews ranged between 50% and 92%; seven positive indicators met the criteria for validation analysis, but all had an AUC below 0.6. Reported prevalence for 15 of the 18 negative maternity care experience indicators was lower than 5% at exit and telephone interviews. For these 15 indicators, agreement between exit and telephone interview was high at over 80%. Just three negative indicators met the criteria for validation analysis, and all had an AUC below 0.6.

Conclusions

The telephone interviews conducted 14 months after childbirth did not yield results that were consistent with exit interviews conducted at the time of facility discharge. Women’s reports of experience of childbirth care may be influenced by the location of reporting or changes in the recall of experiences of care over time.
Why do people take part in atrial fibrillation screening? Qualitative interview study in English primary care
Authors: Hoare Sarah , Powell Alison , Modi Rakesh Narendra , Armstrong Natalie , Griffin Simon J , Mant Jonathan , Burt Jenni
Published: March 2022

Objectives

There is insufficient evidence to support national screening programmes for atrial fibrillation (AF). Nevertheless, some practitioners, policy-makers and special interest groups have encouraged introduction of opportunistic screening in primary care in order to reduce the incidence of stroke through earlier detection and treatment of AF. The attitudes of the public towards AF screening are unknown. We aimed to explore why AF screening participants took part in the screening.

Design

Semistructured longitudinal interview study of participant engagement in the SAFER study (Screening for Atrial Fibrillation with ECG to Reduce stroke). We undertook initial interviews face to face, with up to two follow-up telephone interviews during the screening process. We thematically analysed and synthesised these data to understand shared views of screening participation.

Setting

5 primary care practices in the East of England, UK.

Participants

23 people taking part in the SAFER study first feasibility phase.

Results

Participants were supportive of screening for AF, explaining their participation in screening as a ‘good thing to do’. Participants suggested screening could facilitate earlier diagnosis, more effective treatment, and a better future outcome, despite most being unfamiliar with AF. Participating in AF screening helped attenuate participants’ concerns about stroke and demonstrated their commitment to self-care and being a ‘good patient’. Participants felt that the screening test was non-invasive, and they were unlikely to have AF; they therefore considered engaging in AF screening was low risk, with few perceived harms.

Conclusions

Participants assessed the SAFER AF screening programme to be a legitimate, relevant and safe screening opportunity, and complied obediently with what they perceived to be a recommendation to take part. Their unreserved acceptance of screening benefit and lack of awareness of potential harms suggests that uptake would be high but reinforces the importance of ensuring participants receive balanced information about AF screening initiatives.

Trial registration number

ISRCTN16939438; Pre-results.
Infection-related and lifestyle-related cancer burden in Kampala, Uganda: projection of the future cancer incidence up to 2030
Authors: Asasira Judith , Lee Sanghee , Tran Thi Xuan Mai , Mpamani Collins , Wabinga Henry , Jung So-Youn , Chang Yoon Jung , Park Yikyung , Cho Hyunsoon
Published: March 2022

Objectives

In Uganda, infection-related cancers have made the greatest contribution to cancer burden in the past; however, burden from lifestyle-related cancers has increased recently. Using the Kampala Cancer Registry data, we projected incidence of top five cancers, namely, Kaposi sarcoma (KS), cervical, breast and prostate cancer, and non-Hodgkin’s lymphoma (NHL) in Uganda.

Design

Trend analysis of cancer registry data.

Setting

Kampala Cancer Registry, Uganda.

Main outcome measure

Cancer incidence data from 2001 to 2015 were used and projected to 2030. Population data were obtained from the Uganda Bureau of Statistics. Age-standardised incidence rates (ASRs) and their trends over the observed and projected period were calculated. Percentage change in cancer incidence was calculated to determine whether cancer incidence changes were attributable to cancer risk changes or population changes.

Results

It was projected that the incidence rates of KS and NHL continue to decrease by 22.6% and 37.3%, respectively. The ASR of KS was expected to decline from 29.6 per 100 000 population to 10.4, while ASR of NHL was expected to decrease from 7.6 to 3.2. In contrast, cervical, breast and prostate cancer incidence were projected to increase by 35.3%, 57.7% and 33.4%, respectively. The ASRs of cervical and breast were projected to increase up to 66.1 and 48.4 per 100 000 women. The ASR of prostate cancer was estimated to increase from 41.6 to 60.5 per 100 000 men. These changes were due to changes in risk factors and population growth.

Conclusion

Our results suggest a rapid shift in the profile of common cancers in Uganda, reflecting a new trend emerging in low/middle-income countries. This change in cancer spectrum, from infection-related to lifestyle-related, yields another challenge to cancer control programmes in resource-limited countries. Forthcoming cancer control programmes should include a substantial focus on lifestyle-related cancers, while infectious disease control programmes should be maintained.
Qualitative analysis of topical corticosteroid concerns, topical steroid addiction and withdrawal in dermatological patients
Authors: Tan Sean , Phan Phillip , Law Je Yin , Choi Ellie , Chandran Nisha Suyien
Published: March 2022

Objective

To explore the phenomenon of topical corticosteroid (TCS) phobia and comprehensively understand the factors driving TCS concerns, in particular pertaining to steroid addiction and withdrawal.

Design

Prospective qualitative study using 1:1 in-depth semistructured interviews and analysed using grounded theory.

Participants

Patients with a prior experience of TCS use for a dermatological condition recruited from a tertiary academic dermatology clinic, or through word of mouth and online social media platforms.

Results

26 participants encompassing those with positive, neutral and negative opinions towards TCS were interviewed. 13 reported having topical steroid addiction or withdrawal. The drivers of TCS concerns could be categorised into seven themes: attitudes towards TCS (comprising beliefs and knowledge about TCS), availability of alternatives, treatment inconvenience, personality, patient’s ongoing evaluation of clinical response to TCS, doctor–patient relationship and healthcare-seeking behaviour. Of mention, patients placed high value and trust on their own experiences with TCS, such as their perceived experienced side effects. The doctor who failed to acknowledge the patient’s opinions and instead emphasised the safety of TCS was often viewed as dismissive, resulting in a deteriorating patient–doctor relationship.

Conclusion

Provision of knowledge and education is important but may be ineffective if the basis for TCS concern regarding safety is reasonable, or when the patient has a firmly established belief supporting his/her concern. In such instances, failure to acknowledge and respect the patient’s decision to avoid TCS could worsen the doctor–patient relationship.
Unburdening expectation and operatingbetween: architecture in support of palliative care
Authors: Mclaughlan Rebecca , George Beth
Published: March 2022

The role of design and materials in the enactment and experience of healthcare has gained increasing attention across the fields of evidence-based design, architecture, anthropology, sociology and cultural geography. Evidence-based design, specifically, seeks to understand the ways in which the built environment can support the healing process. In the context of palliative care, however, the very measure of healing differs vastly. Physicians Mount and Kearney suggest that ‘it is possible to die healed’, and that such healing can be facilitated through the provision of ‘a secure environment grounded in a sense of connectedness’ (2003: 657). Acknowledging this critical difference raises important questions around the various ways through which the built environment might support healing, but also about the potential of architecture to impart care. This paper reports on 15 interviews with architects, experienced in the design of palliative care settings, from the UK, USA and Australia, to provide a deeper understanding of the questions being asked within the briefing processes for these facilities, the intentions embedded in the ways that architects respond, and the kinds of compromises deemed allowable (by various stakeholders) within the procurement process. Our findings suggest that palliative care architects often respond to two briefs, one explicit and the other unspoken. Design responses in relation to the first include: formally expressing a differentiation in the philosophy of care (signalling difference), attention to quality, extending comfort and providing ‘moments’. The second relates to the unburdening of palliative care facilities from their associative baggage and responding to the tension between the physical and imaginative inhabitation of space. In revealing the presence of this hidden brief, and the relationship between the two, this paper invites a broader discussion regarding the capacity of architecture to support palliative care patients, their families and staff.
Chromosome number, heterochromatin, and genome size support recent polyploid origin of the Epidendrum nocturnum group and reveal a new species (Laeliinae, Orchidaceae)
Authors: Cordeiro Joel M.P. , Chase Mark W. , Hágsater Eric , Almeida Erton Mendonça , Costa Lucas , Souza Gustavo , Nollet Felipe , Felix Leonardo P.
Published: March 2022

The Epidendrum nocturnum Jacq. group comprises about 60 species. Nine species occur in Brazil, predominantly in the Atlantic and Amazon Forests. The group is taxonomically complex because its species are morphologically similar and not easily distinguished. The main objective of this work is to characterize their chromosome evolution and how this has affected species delimitation in Brazilian representatives of the E. nocturnum group. We used chromosome numbers, heterochromatin band patterns, and genome size variation to better understand the chromosome variation, species delimitation, and the relationship among seven representatives of this group. A new species from the Cerrado/Amazon Rainforest ecotone is described based on cytological and morphological characters. The new species, Epidendrum pareciense sp. nov., is a diploid (2n = 40), Epidendrum bahiense Rchb.f., Epidendrum carpophorum Barb.Rodr., Epidendrum micronocturnum Carnevali & G.A.Romero, Epidendrum purpureocaulis Sambin & Essers, and E. nocturnum are tetraploids (2n = 80), and Epidendrum tumuc-humaciense (Veyret) Carnevali & G.A.Romero is hexaploid (2n = 120), the last a new ploidy for the group. Heterochromatin in these species is characterized by guanine-cytosine-rich regions (cromomycin A3 (CMA+) bands) on proximal and terminal regions associated with NORs. Genome size and numbers of CMA terminal bands are directly related to ploidy, suggesting that diploidization has not yet occurred and supporting the hypothesis of a recent polyploid origin for the E. nocturnum group.
Investigation of welding parameters effects on temperature field and structure field during laser-arc hybrid welding
Authors: Gui Xiaoyan , Gao Xiangdong , Zhang Yanxi , Wu Jiakai
Published: March 2022

Thermo-structural weak coupling model was adopted in numerical simulation of laser-arc hybrid T-joint welding. Gauss surface heat source and Rotary-Gauss body heat source were used to form a combined heat source in the temperature field analysis and simulate the arc and laser heat source. The laser-arc hybrid overlaying welding test of 304 stainless steel was carried out, and the weld molten pool morphology was obtained by metallographic corrosion test. The test results of a molten pool morphology show that the combination heat source can better simulate the laser-arc hybrid welding process. The effects of laser power, arc power and welding speed on residual stress and deformation of T-joint in laser-arc hybrid welding were studied by orthogonal experiments. Experimental results show that the arc power has great influence on the depth-width ratio, the laser power has great influence on the welding residual stress, and the welding speed has great influence on the thermal deformation. Through quantitative analysis and comparison, the optimal parameters were found during laser-arc hybrid welding.
Ricci curvature for biwarped product submanifolds of the type N𝜃1 ×f2N𝜃2 ×f3N𝜃3 in Kenmotsu space forms
Authors: Khan Meraj Ali , Hui Shyamal Kumar , Mandal Pradip , Al-Khaldi A. H.
Published: March 2022

The major goal of this work is to express the Ricci curvature inequality for biwarped product submanifold of the type [Formula: see text] isometrically immersed in a Kenmotsu space form via terms of the squared norm of mean curvature vector and warping functions, where [Formula: see text], [Formula: see text] and [Formula: see text] are the slant submanifolds with slant angles [Formula: see text], [Formula: see text] and [Formula: see text]. The interpretations of equality are also explored. In addition, we provide several applications of these inequalities.
Weak deflection angle of light in two classes of black holes in nonlinear electrodynamics via Gauss–Bonnet theorem
Authors: El moumni H. , Masmar K. , Övgün A.
Published: March 2022

In this paper, we study the gravitational lensing by some black hole classes within the nonlinear electrodynamics in weak field limits. First, we calculate an optical geometry of the nonlinear electrodynamics black hole and then we use the Gauss–Bonnet theorem for finding deflection angle in weak field limits. The effect of nonlinear electrodynamics on the deflection angle in leading order terms is studied. Furthermore, we discuss the effects of the plasma medium on the weak deflection angle.
Hypersurfaces with a common asymptotic curve in the 4D Galilean space 𝔾4
Authors: Makki Roa
Published: March 2022

In this study, we investigate how to construct hypersurfaces using an asymptotic curve in the 4D Galilean space [Formula: see text]. Then, by utilizing the Serret–Frenet frame, we give the conditions that a curve becomes asymptotic on a hypersurface when the marching-scale functions are three types of functions. After then, an example connected to our method is given for the aim of visibility.
Learning-Replay Based Automated Robotic Testing for Mobile App
Authors: Xue Feng , Wu Junsheng , Zhang Tao
Published: March 2022

Record-replay testing is widely used in mobile app testing as an automated testing method. However, the current record-replay methods are closely dependent on the internal information of the device or app under test. Due to the diversity of mobile devices and system platforms, their practical use is limited. To break this limitation, this paper proposes an entirely black-box learning-replay testing approach by combining robotics and vision technology to achieve a record-replay testing that can support cross-device and cross-platform. Firstly, vision technology is used to extract the critical information of GUI and gesture actions during the tester’s testing process; secondly, the GUI composition and test actions are analyzed to form a test sequence; finally, the robotic arm is guided to complete the replay of the test sequence through visual judgment. On the one hand, the approach in this paper does not access the interior of the app, shielding the association between test actions and device; on the other hand, it captures more abstract test action information instead of simple operation location records and supports more flexible test action replay. We demonstrate the effectiveness of this approach by evaluating the learning-replay of 12 popular apps for 13 typical scenarios on the same device, across devices, and across platforms.
Application of Digital Technology-Based TPACK in English Translation
Authors: Du Min
Published: March 2022

Internet teaching encourages the societal improvement of teaching and learning systems. In this paper, we examine big data and interactive teaching modes and the design process of interactive teaching modes. We propose an interactive teaching model that uses big data in learning analytics and content analysis to optimize the whole teaching practice application process. We also show how to use current technology, build a great teaching management platform, and raise the teaching management level. In this paper, we also examine and develop an English translation teaching model based on TPACK and propose the use of TPACK in technical English translation based on big data platforms, with the purpose of “cultivating students to improve translation abilities”. The model is effective and promotes the improvement of translation teaching levels.
An Efficient Method for Diagnosing Brain Tumors Based on MRI Images Using Deep Convolutional Neural Networks
Authors: Han-Trong Thanh , Nguyen Van Hinh , Nguyen Thi Thanh Huong , Tran Anh Vu , Nguyen Tuan Dung , Vu Dang Luu
Published: March 2022

This paper proposes a system to effectively identify brain tumors on MRI images using artificial intelligence algorithms and ADAS optimization function. This system is developed with the aim of assisting doctors in diagnosing one of the most dangerous diseases for humans. The data used in the study is patient image data collected from Bach Mai Hospital, Vietnam. The proposed approach includes two main steps. First, we propose the normalization method for brain MRI images to remove unnecessary components without affecting their information content. In the next step, Deep Convolutional Neural Networks are used and then we propose to apply ADAS optimization function to build predictive models based on that normalized dataset. From there, the results will be compared to choose the most optimal method. Those results of the evaluated algorithms through the coefficient F1-score are greater than 94% and the highest value is 97.65%.
Digital Art Pattern Design Based on Visual Material Colouring Intelligent Programming System
Authors: Liu Yan , Liang Chong , Xu Huan , Wang Fen , Hao Yuanfeng , Dong Jianhan , Dong Yu , Guo Dong , Sun Tao , Yu Ping
Published: March 2022

With the continuous enhancement of computer technology, digital technology brings more convenience to people with its powerful functions. After the digital technology is applied to the design field, it greatly expands the creative space of art design. In the digital age, fabric printing and dyeing design needs to be combined with digital technology under the guidance of art theory. Traditional flat patterns can no longer satisfy people’s pursuit of visual illusion patterns with a sense of space and three-dimensionality. The use of computer representation can realize the innovative artistic design and can directly generate various highly creative visual images in the computer according to the theme and creative needs. We input the digital data related to the fabric, such as graphics, photographic photos, logos, fonts, and textures, into the computer and then use various application software to perform various special effects on them to produce creative, unique, and surprising picture effects. In the aspect of exploring the meaning of the theme, the application of spatial expression means is studied, and practical research is carried out to guide the design of works with spatial beauty and creativity. In view of the neglect of artistic design, on the basis of studying the space art expression of traditional printing and dyeing process patterns, the traditional space art expression is combined with computer image processing technology. And special techniques are used to create differences in various textile fabrics and garments. We use the software of digital art design to carry out the artistic creation practice of spatial expression. Through the application of computer software functions, combined with the guidance of spatial expression techniques, the design comparison of patterns is carried out, which provides design practice ideas for the integration and innovation of traditional printing and dyeing technology and modern design. The implementation of the visual material colouring programming system reduces the coupling between artists and programmers and reduces the coupling between art collections and producers. The colouring program in the process of art pattern development improves the efficiency of art design.
Assessment of the Teratogenic Effect of Sulfadoxine-Pyrimethamine on the Chicken Embryo
Authors: Tari Rachida Moussa , Diallo Aboudoulatif , Kouame Emmanuelle , Assogba Phénix , Badjabaissi Essotolom , Povi Lawson-Evi , Bakoma Batomayena , Potchoo Yao , Tona Kokou
Published: March 2022

Background. The sulfadoxine-pyrimethamine combination is a product used in the intermittent preventive treatment (IPT) of malaria in pregnant women in our country. To date, there is very little data on the teratogenic effect of this product. This study proposed to evaluate the teratogenic effect of sulfadoxine-pyrimethamine on chicken embryos. Methods. The teratogenic effect of the product was evaluated on chicken embryos at a dose of 1.3 mg/g sulfadoxine and 0.06 mg/g pyrimethamine. The product was injected before the start of incubation and on days 12, 14, 16, and 18 of incubation. One batch received a double injection of the product on days 16 and 18 of incubation. The quality of the hatched chicks was evaluated by the Tona Score followed by the determination of hematological and biochemical parameters. Results. From the aforementioned, it appears that the eggs treated with sulfadoxine-pyrimethamine significantly decreased the hatchability rate of the eggs. The chicks obtained were all of very good quality. Apart from a significant decrease in the weight of the chicks of the batch that received the injection twice and a significant increase in the weight of the yolk sac of the chicks of the batch that received the injection on day 16 compared to the control, no variation was obtained. A significant increase in the white blood cell count of the chicks compared to the control was reported in the chicks of the batch injected before incubation and on day 12, as well as a significant increase in the platelet count of the chicks of the batch injected twice. For biochemical parameters, no significant difference was reported in ALT and AST. Conclusion. Sulfadoxine-pyrimethamine decreased egg hatch and caused an increase in embryo and chick mortality as well as a loss in relative chick weight and an increase in relative yolk sac weight. More in-depth studies would be needed on sulfadoxine-pyrimethamine teratogenicity and the benefit/risk ratio of this drug during pregnancy.
Research on Flow Characteristics of a Variable Mach Number Aerodynamic Test Device by a Rotating Profile
Authors: Chen Zaicheng , Liu Yang , Bao Futing , Wei Ran
Published: March 2022

In the development process of aircraft, it needs to be tested in different incoming flow environments. Therefore, the test equipment that can provide a wide Mach number range and a fast-response flow field has always been a research hotspot. In this paper, a variable Mach number aerodynamic test device by a rotating profile is constructed with a divergent nozzle. The flow field parameters of the device are calculated by numerical simulation. The influence of the initial divergent half-angle of the cubic curve profile and the profile rotation mode on the test area is analyzed by using the flow quality evaluation method. The results show that when the incoming flow Mach number is 1.5 to 3.0, by adjusting the incoming flow Mach number and the expansion ratio of the test device, the Mach number in the test area can change continuously from 3 to 5 and the atmospheric environment at an altitude of 11 km to 20 km can be simulated. The test device composed of the cubic curve profile with the same initial divergent half-angle as the original straight line has a better flow quality. The both-side rotation mode can ensure the symmetry of the flow direction better than the one-side rotation mode.
Joint Extraction of Long-Distance Entity Relation by Aggregating Local- and Semantic-Dependent Features
Authors: Wei Xiao , Chen Yongqi
Published: March 2022

The relations among long-distance entities are important for text understanding. Long-distance entities mean a pair of entities separated by more words in the text. Most current work of the joint extraction of entity relation is between entities that are close together. These methods are not suitable for long-distance entity relation extraction for they usually ignore the interaction between long-distance entities. In this paper, we propose Long-Distance Feature Aggregation Model (LDFAM), an end-to-end long-distance entity relation joint extraction model, which uses a Bi-GRU and weighted graph neural network to model text and learn its local- and semantic-dependent features. The long-distance dependence between entities is obtained by aggregating these two types of features. For entity recognition, we use conditional random fields to further obtain the dependency information between tags. For relation extraction, we fuse entity tag information for biaffine pairwise scoring. Experimental results on NYT and SemEval2010-Task8 datasets show that our model has achieved significant improvements compared to the baseline model. Finally, we apply the model to the field of material science to extract entity relationship knowledge from material literature. Experimental results show that benefiting from the long-distance entity relation extraction, the proposed method can get more useful knowledge from material literature and improve the knowledge coverage of material domain knowledge acquisition.
Home-Based Remedies to Prevent COVID-19-Associated Risk of Infection, Admission, Severe Disease, and Death: A Nested Case-Control Study
Authors: Nuertey Benjamin Demah , Addai Joyce , Kyei-Bafour Priscilla , Bimpong Kingsley Appiah , Adongo Victor , Boateng Laud , Mumuni Kareem , Dam Kenneth Mibut , Udofia Emilia Asuquo , Seneadza Nana Ayegua Hagan , Calys-Tagoe Benedict NL , Tette Edem M. A. , Yawson Alfred Edwin , Soghoian Sari , Helegbe Gideon K. , Vedanthan Rajesh
Published: March 2022

Objective. This study aimed at determining the various types of home-based remedies, mode of administration, prevalence of use, and their relevance in reducing the risk of infection, hospital admission, severe disease, and death. Methods. The study design is an open cohort of all participants who presented for testing for COVID-19 at the Infectious Disease Treatment Centre (Tamale) and were followed up for a period of six weeks. A nested case-control study was designed. Numerical data were analysed using STATA version 14, and qualitative data were thematically analysed. Results. A total of 882 participants made up of 358 (40.6%) cases and 524 (59.4%) unmatched controls took part in the study. The prevalence of usage of home-based remedies to prevent COVID-19 was 29.6% (n = 261). These include drinks (34.1% (n = 100)), changes in eating habits/food (33.8% (n = 99)), physical exercise (18.8% (n = 55)), steam inhalation (9.9% (n = 29)), herbal baths (2.7% (n = 8)), and gurgle (0.7 (n = 2)). Participants who practiced any form of home-based therapy were protected from SARS-CoV-2 infection (OR = 0.28 (0.20–0.39)), severe/critical COVID-19 (OR = 0.15 (0.05–0.48)), hospital admission (OR = 0.15 (0.06–0.38)), and death (OR = 0.31 (0.07–1.38)). Analysis of the various subgroups of the home-based therapies, however, demonstrated that not all the home-based remedies were effective. Steam inhalation and herbal baths were associated with 26.6 (95% CI = 6.10–116.24) and 2.7 (95% CI = 0.49–14.78) times increased risk of infection, respectively. However, change in diet (AOR = 0.01 (0.00–0.13)) and physical exercise (AOR = 0.02 (0.00–0.26)) remained significantly associated with a reduced risk of infection. We described results of thematic content analysis regarding the common ingredients in the drinks, diets, and other home-based methods administered. Conclusion. Almost a third of persons presenting for COVID-19 test were involved in some form of home-based remedy to prevent COVID-19. Steam inhalation and herbal baths increased risk of COVID-19 infection, while physical exercise and dietary changes were protective against COVID-19 infection and hospital admission. Future protocols might consider inclusion of physical activity and dietary changes based on demonstrated health gains.
The Industrial Product Design Service System Based on the Sustainable Development of the Internet of Things
Authors: Guo Linjing , Chen Bohong
Published: March 2022

The study aims at the sustainable development of the Internet of Things. This paper studies the industrial product design service system and understands the relevant knowledge and theories of the industrial product design service system on the basis of literature data, and then the sustainable development of Internet of Things is set as the goal, and the industrial product design service system is designed and tested. The industrial revolution in the 18th century brought about technological innovation and economic take-off in today’s society, which completely changed people’s lifestyles and was also accompanied by a series of environmental, social, and economic problems. Abnormal weather, lack of resources, and serious waste are becoming more and more obvious. The study problem that needs to be solved urgently is the contradiction between the environment and the economy. As a result, many companies, organizations, and individuals gradually began to find effective ways and means to solve this problem, and the concept of sustainable design came into being. The study test results show that the overall system evaluation designed in this paper is relatively good: 67% of the system function evaluation scores above 3, and 66% of the system interface evaluation scores above 3 points.
Phillygenin Protects the Intestinal Barrier from Dysfunction via let-7b Signaling Pathway and Regulation of Intestinal Microbiota
Authors: Feng Huiping , He Ling , Wang Zihua , Pi Bin , Liu Zhihua
Published: March 2022

The study investigates the positive effects of phillygenin on intestinal tight junction via the let-7b signaling pathway and the regulation of intestinal microbiota. The expression levels of tight junction proteins are determined through PCR and Western blot. DSS-induced mice colitis is used to verify the protective effects of phillygenin on intestinal barrier and tight junction. Fecal microbiota transplantation is used to verify the role intestinal microbiota. let-7b is detected in the colon tissues of patients with acute stercoral obstruction. Phillygenin could promote the expression of occludin, which might be inhibited by let-7b inhibitor. DSS-induced mice colitis showed that phillygenin could lower the colonic permeability and maintain the tight junction-associated proteins. The effects of phillygenin could be deprived by anti-let-7b and rescued by FMT of normal intestinal microbiota. Clinical samples verified a lower level of let-7b in stercoral obstruction patients. Phillygenin could protect the intestinal barrier from dysfunction via the signaling pathway of let-7b by regulating intestinal microbiota.
Modeling of Residential Environment Artistic Design Based on Multisensor Data Fusion
Authors: Yu Yang
Published: March 2022

The development of a 3D city model is accompanied by the continuous progress of technical knowledge, the continuous increase of public interest in it, and the rapid progress of national knowledge. The use of a 3D city model has become the common concern of academia, enterprises, and most users. The article takes the community as an example to summarize the research overview and basic knowledge of the 3D model. From the aspects of 3D city location data collection technology, 3D city model technology, 3D exhibition, etc., the advanced technology in 3D city model, 3DGIS software system, and other issues are discussed and studied, and the current state-of-the-art technology development level is summarized and analyzed. The article first introduces the purpose and importance of the 3D town model and further analyzes the development context, research background, and research content at home and abroad. Secondly, the theoretical basis of the 3D data model, study location data characteristics, location data model configuration, location data survey structure, and location data model construction requirements were put forward. Then, 3DMax software was used to build a house model and finally find it in OpenGL software. The effective distance of the detector is 0.4~3.5 m, and the maximum resolution is

640
×
480

. It also introduces the realization of 3D architectural model storage and the visual expression of 3D city modeling. The article uses the Kinect depth sensor to recreate a simple static dimensional scene.
In Silico Analysis Identifies Upregulated lncRNA DLGAP1-AS1 Which Is Correlated to Poor Prognosis and Promotes Cell Proliferation in Glioblastoma
Authors: Huang Yinxing , Liu Li , Fang Meng , Yan Wangjun
Published: March 2022

Long noncoding RNAs have been reported to regulate the tumorigenesis, growth, and metastasis of glioblastomas. In this study, we identified 1623 differently expressed mRNAs and 38 lncRNAs utilizing the CGGA and TCGA databases. Among these mRNAs and lncRNAs, we focused on DLGAP1-AS1 in this study. The results demonstrated that DLGAP1-AS1 was higher in WHO IV glioma than in WHO II and WHO III gliomas, higher in WHO III glioma than in WHO II glioma samples, higher in IDH1 wildtype glioma than in IDH1-mutant glioma samples, and higher in 1p/19q noncodeletion glioma than in 1p/19q codeletion glioma samples. Moreover, we observed that higher expression levels of DLGAP1-AS1 were correlated to shorter OS time in both low-grade and high-grade gliomas. Next, we evaluated the function of DLGAP1-AS1 in GBM using in vivo experiments. The data revealed that DLGAP1-AS1 knockdown greatly hindered U87 cell and U251 cell proliferation. Using coexpression network analysis, we identified that ATG4A was a potential downstream target of DLGAP1-AS1. The further analysis showed that ATG4B was significantly upregulated and correlated to shorter OS time in gliomas using both the CGGA and TCGA databases. Finally, we showed that ablated ATG4B greatly hindered GBM cell proliferation. Our conclusion suggested that DLGAP1-AS1 may be a potential prognosis biomarker and facilitated the occurrence and development of glioma via ATG4A in GBM.
LGBM-CBFS: A Heuristic Feature Sampling Method Based on Tree Ensembles
Authors: Zhou Yu , Li Hui , Chen Mei
Published: March 2022

Gradient boosting decision tree (GBDT) is widely used because of its state-of-art performance in academia, industry, and data science competitions. The efficiency of the model is limited by the overwhelming training cost with the surge of data. A common solution is data reduction by sampling on training data. Current popular implementations of GBDT such as XGBoost and LightGBM both supports cut the search space by using only a random subset of features without any prior knowledge, which is ineffective and may lead the model fail to converge when sampling on a high-dimensional feature space with a small sampling rate assigned. To mitigate this problem, we proposed a heuristic sampling algorithm LGBM-CBFS, which samples features based on an available prior knowledge named “importance scores” to improve the performance and the effectiveness of GBDT. Experimental results indicate that LGBM-CBFS obtains a higher level of model accuracy than uniform sampling without introducing unacceptable time cost in the sparse high-dimensional scenarios.
Regulatory Mechanism of circEIF4G2 Targeting miR-26a in Acute Myocardial Infarction
Authors: Zhang Zaiyong , Li Jianhao , Long Cheng , Han Yuanyuan , Fan Jun , Misrani Afzal , Ji Xiangyu
Published: March 2022

Background. Acute myocardial infarction (AMI) involves a series of complex cellular and molecular events, including circular RNAs (circRNAs), microRNAs (miRNAs) and other noncoding RNAs. Objective. In this study, the regulation mechanism of circEIF4G2 acting on miR-26a on HUVECs (Human Umbilical Vein Endothelial Cells) proliferation, cell cycle and angiogenesis ability was mainly explored in the vascular endothelial growth factor induced (VEGF-induced) angiogenesis model. Methods. VEGF induced HUVECs angiogenesis model was constructed, and the expression of circEIF4G2 and miR-26a in VEGF model was detected by qRT-PCR. When circEIF4G2 and miR-26a were knocked down or overexpressed in HUVECs, qRT-PCR was used to detect the expression of circEIF4G2 and miR-26a, CCK-8 was used to detect cell proliferation, flow cytometry was used to detect the cell cycle transition of HUVECs, and cell formation experiment was used to detect the ability of angiogenesis. MiRanda database and Targetscan predicted the binding site of circEIF4G2 and miR-26a, lucifase reporting assay and RNA pull down assay verified the interaction between circEIF4G2 and miR-26a. Results. After HUVECs were treated with VEGF, circEIF4G2 was significantly upregulated. After circEIF4G2 was knocked down, the proliferation and angiogenesis of HUVECs cells were decreased, and the process of cell cycle G0/G1 phase was blocked. The overexpression of miR-26a reduced the proliferation and angiogenesis of HUVECs cells and blocked the cell cycle progression of G0/G1 phase. Double lucifase reporter gene assay verified that circEIF4G2 could directly interact with miR-26a through the binding site, and RNA Pull down assay further verified the interaction between circEIF4G2 and miR-26a. When circEIF4G2 and miR-26a were knocked down simultaneously in HUVECs, it was found that knocking down miR-26a could reverse the inhibition of circEIF4G2 on cell proliferation, cycle and angiogenesis. Conclusion. In the VEGF model, circEIF4G2 was highly expressed and miR-26a was low expressed. MiR-26a regulates HUVECs proliferation, cycle and angiogenesis by targeting circEIF4G2.
A Larger Capacity Data Hiding Scheme Based on DNN
Authors: Liu Lianshan , Meng Lingzhuang , Zheng Weimin , Peng Yanjun , Wang Xiaoli
Published: March 2022

With the in-depth research in data hiding technology, the latest data hiding schemes using deep neural network (DNN) could hide the full-size color image into the same size color image. This paper proposed a larger capacity data hiding scheme based on DNN, which could hide large-size color image into small-size color image. This scheme used DNN in both the data hiding stage and data extraction stage. And the two networks were obtained through adversarial training and used in pairs. The information ratio between the carrier image and the secret image had reached 1 : 4. The image obtained after hiding the data did not change much compared with the carrier image, and the extracted image had the same size and no visual difference compared with the secret image. It could be seen from the simulation experiment that, compared with the existing DNN-based data hiding scheme, even if the capacity of the proposed scheme was 4 times larger than that of the existing scheme, the visual effect and PSNR were also better than some existing schemes.