bluuebunny/crossref_metadata_2025 huggingface dataset:
Representation of the Dionysian-mysterial plot in the book of poems Pilot Stars by Vyacheslav Ivanov
Authors:   Smolensk State University, Kaianidi Leonid G.
Published: December 2024

In the book Pilot Stars (Kormchiye zvyozdy), the first poetic explication of the Dionysian-mysterial plot takes place. This plot is a system, which, based on the Orphic myth of the tearing of Dionysus, performs a constructive-paradigmatic function in Ivanov, modeling a variety of semantic structures (the system of images, the structure of the plot, etc.). The aim of this work is to describe features of the representation of the Dionysian-mysterial plot in the first book by Vyacheslav Ivanov. The main material of the study was Pilot Stars. To understand poetic texts, the author used Ivanov’s monograph Dionysus and Early Dionysianism, his philosophical articles and extensive epistolary works, as well as the philosophical heritage of the Neoplatonics-Orphics. In the course of the research, the author used comparative, hermeneutic, structuralsemantic methods, the method of contextual and motivic-thematic analysis. First, the author described the structure and symbolic potential of the Dionysian-mysterial plot. It splits into two parts: the plot of the descent, in the center of which is the death of Dionysus and the fall of humankind, and the plot of the ascent, in which the resurrection of Dionysus and the rebirth of humankind take place. The Dionysian-mysterial motifs are concentrated mainly in the two final cycles of the book: “Evia” and “Suspiria”. This
is explained by the history of their creation: they were created in 1902, when Ivanov, wanting to overcome the influence of Friedrich Nietzsche in the field of religious history, studied Dionysian cults at the German Archaeological Institute in Athens. In lyrical texts, unlike in Ivanov’s major works (poems, tragedies), the representation of the Dionysian-mysterial plot has its own peculiarities. Firstly, the poems contain only two or three Dionysian-mysterial motifs or images, and the whole plot never appears in its entirety. These motifs tend to the two triads of the Dionysian-mysterial plot – the mysterial one (the tearing of Dionysus as the universal fall) and the soteriological one (the redemption of humanity through its reunion with the resurrected Dionysus). In Pilot Stars, the Dionysian-mysterial plot is represented with the help of astral symbolism. It is represented antinomically. As a disconnected multitude, the starry sky symbolizes the tearing of Dionysus. In this case, the stars are parts of the torn cosmic body of Dionysus, titans filled with Dionysian energies, and at the same time a host of
souls whom Dionysus brings down to the world of the dead. As a multiple unity, the starry sky is a symbol of the risen Dionysus, who raises the souls of the dead from the world of the dead to the world of the living, as well as a conciliar multitude of titanic beings transformed by Dionysian energies.
On the “phrase-for-phrase” translation of The Song of Igor’s Campaign by Xiyin Li
Authors:   Lomonosov Moscow State University, Li Ziwei
Published: December 2024

The second full Chinese translation of The Song of Igor’s Campaign was completed by Xiyin Li at the end of the 20th century. In the preface of his work, the translator clearly pointed out his approach to translation, namely, “translate phrase-forphrase”. The objective of this study was to analyze the essence of his translation approach based on not only the translated text, but also its paratext. The paratext was studied in two aspects, the form and the content. The contradiction between the rich form and the random content was explained by investigating the general historical influences on the translator. Moreover, the interaction of the paratext of Li’s work with that from the first full translation of The Song of Igor’s Campaign made by Huangnu Wei was taken into account to interpret the reason for Li’s pursuit of formal innovation. In order to analyze the translated text, Svyatoslav’s “Golden Word” was quoted as an example. Firstly, Li’s Chinese translation and its reverse translation into Russian were presented parallelly with the original text reconstructed by V. V. Kolesov and the Old Russian text from Li’s translation. Then the semantic equivalence of the original and the target languages was described and compared in linguistic and literary aspects. The analyzed results indicated that Li intended to use circumlocution to make his work different from Wei’s. The novelty of this research lies in the approach where translation activity is assessed against the socio-cultural background and from the perspective of interaction among different translators.
Классификация неисключительных прав в Гражданском кодексе РФ в контексте статуса иностранного автора
Authors: Lutkova O.
Published: December 2024

Предметом исследования являются нормы Гражданского кодекса Российской Федерации, закрепляющие неисключительные права автора, классификацию неисключительных прав и возможное влияние на статус иностранного автора в Российской Федерации. Особое внимание уделено следующим аспектам: 1) выявлению основных признаков, характеризующих неимущественные права и иные права по законодательству РФ; 2) уточнению, на основании выявленных характеристик неимущественных и иных прав автора, классификации неисключительных авторских прав в законодательстве России; 3) оценке соответствия классификации неисключительных прав автора в ГК РФ международно-правовым обязательствам Российской Федерации; 4) анализу доктринальных позиций и правоприменительной практики по рассматриваемому вопросу; 5) прогнозированию возможных проблем в сфере регулирования неимущественных прав иностранных авторов в Российской Федерации и предложение путей их устранения. В исследовании использованы методы правового анализа, правового моделирования, правового прогноза, методы сравнительного правоведения и исторического анализа. В статье сделано два основных вывода. Во-первых, выявлены пробелы в классификации неисключительных прав автора в соответствии с ГК РФ как неимущественных и иных, и внесены предложения по уточнению классификации с учетом правотворческой практики отдельных государств, российского законодательства, действовавшего до вступления в силу ГК РФ, современных обобщений российской правоприменительной практики, а также с учетом международно-правовых обязательств Российской Федерации (по Бернской конвенции об охране литературных и художественных произведений 1886 г.). Помимо прав, четко обозначенных в ст. 1228 ГК РФ, к категории неимущественных прав предложено отнести право на неприкосновенность и защиту произведения от искажения. К категории иных прав, помимо обозначенных в ст. 1226 ГК РФ, предложено относить право на обнародование произведения, право на отзыв, право на получение вознаграждения за использование служебного произведения и др. Во-вторых, выявлены риски появления возможных проблем в сфере регулирования неимущественных прав иностранных авторов на территории России и предложены варианты их устранения.
Взгляд конституционалиста на проблему правосознания
Authors: Lukyanova Elena
Published: December 2024

Рецензия на кн.: Сатаров Г.А., Благовещенский Ю.Н., Римский В.Л. Социологический анализ правосознания судей, населения и предпринимателей (М.: ИНДЕМ — Фонд «Либеральная миссия», 2015, 137 с.)
Компенсация или профанация?
Authors: Alekseevskaya Ekaterina
Published: December 2024

В статье сопоставляются критерии эффективного внутреннего средства правовой защиты от волокиты при рассмотрении дела или при исполнении решения суда, используемые Европейским судом по правам человека, и правовые гарантии, установленные в Федеральном законе от 30 апреля 2010 г. № 68-ФЗ «О компенсации за нарушение права на судопроизводство в разумный срок или права на исполнение судебного акта в разумный срок». Автор делает вывод о сужении правовых возможностей компенсации вреда за волокиту, обращая при этом внимание на то, что ограничение правовых возможностей взыскания компенсации вреда за нарушение права на справедливое судебное разбирательство позиционируется российскими властями как особенность национального регулирования. На примере конкретного дела, относящегося к категории защиты прав потребителей, автор демонстрирует сложившуюся судебную практику применения положений названного закона. Апробация этого закона выявляет его неэффективность и новые нарушения ст. 6 Европейской конвенции о защите прав человека и основных свобод (1950). Причины неэффективности российского закона кроются как в его положениях, так и в процессуальных правилах рассмотрения и разрешения требований заявителей о взыскании компенсации вреда, причиненного судебной волокитой. Анализируя нормы указанного закона и судебную практику его применения, автор делает ряд выводов. Правовой институт компенсации за судебную волокиту не соответствует требованиям эффективного внутреннего средства правовой защиты от судебной волокиты, сформулированным в ст. 13 Европейской конвенции и судебных постановлениях Европейского суда по правам человека по жалобам против России. Исходя из этого, системная проблема чрезмерной длительности судебного процесса и исполнения решения суда государством не решена. Существует объективная потребность в устранении выявленных несоответствий требованиям ст. 6 и 13 Европейской конвенции, как в материальном, так и в процессуальном праве. Практика применения положений Федерального закона от 30 апреля 2010 г. № 68-ФЗ демонстрирует, что имеются значительные трудности в непосредственном применении общепризнанных принципов и норм международного права.
Insights into Antiradical Behavior: Crystal Structures and DFT Analysis of 2-Formylpyridine N4-Allylthiosemicarbazone Salts
Authors: Chumakov Yurii , Graur Vasilii , Graur Ianina , Tsapkov Victor , Garbuz Olga , Gulea Aurelian
Published: December 2024

In this paper, six new salts of 2-formylpyridine N4-allylthiosemicarbazone ([H2L]X∙nH2O, where X is NO3 – (1), NH2SO3 – (2), Cl– (3), Cl3CCOO– (4), Cl2CHCOO– (5), ClCH2COO– (6); n = 0 (1, 3, 5, 6), 1 (2, 4)) were synthesized and physico-chemically characterized by elemental analysis, molar conductivity measurements, FT-IR studies, 1H and 13C NMR. The crystal structures of compounds 1–5 were determined by single-crystal X-ray diffraction. Crystal data analysis shows that the structures of these compounds consist of protonated thiosemicarbazone H2L+, anions of acid residue, and water molecules in 2 and 4. These compounds manifest antiradical activity toward ABTS•+ cation radicals that exceeds the activity of non-protonated thiosemicarbazone HL and Trolox used in medical applications. The most active one is compound [H2L]Cl (3) with an IC50 value of 9.9 μmol/L. Density Functional Theory calculations showed that the electronic structure of cation H2L+ is more favorable for accepting electron if compared with HL.
NCI Biospecimen Evidence-Based Practices (BEBP) - Cell-free miRNA: Blood Collection and Processing v1
Authors: Biorepositories and Biospecimen Research Branch NCI
Published: December 2024

This evidence-based best practice document is applicable to the collection, processing, isolation, and storage of circulating cfmiRNA from plasma or serum that is intended for analysis in clinical and/or research settings; it does not include the requisite processing for analysis of exosomal miRNA. The ISO 21899.2020 standard (Reference 9.1.9) may be useful as a reference for validation and verification of SOPs produced using this BEBP.
Further critical reflections on the notion of a “population psychology”.
Authors: Lamiell James T.
Published: December 2024

The present article extends critical considerations that I offered in an earlier article challenging the proposition by Lundh that population-level research should be regarded as a branch of psychological science. It is again acknowledged that population-level research can track the incidence of psychological phenomena, i.e., sensations, perceptions, judgments, cognitions, emotions, behaviors, etc., within and across various subgroups of individuals, and this, I argue, is what warrants the designation of such research as “psycho-demographic.” Such research can complement, but should not be considered part of, psychological science. It is explained that this view does not require strict adherence to a mechanistic understanding of causation in the domain of psychological phenomena. Finally, it is suggested that drawing and maintaining a clear distinction between psycho-demography and psychological science will help to correct the long-prevalent but false notion that the knowledge produced by population-level research is interpretable as knowledge about individuals.
La simulación absoluta impropia, su prueba y carga
Authors:   Universidad de Antioquia, Gallo Riaño Carlos Mauricio , Vargas Álvarez Anyela Irene ,   Universidad de Antioquia
Published: December 2024

Con la regulación probatoria incorporada en el artículo 1766 del Código Civil colombiano, el cual es transcripción del 1321 del Código Civil francés, la simulación es una categoría negocial, amplificada por la jurisprudencia y la doctrina, en ausencia de previsión legal. En esta, divergen la voluntad exteriorizada de los contratantes, con la voluntad real y oculta, en la que, a su vez, puede estructurarse en otro negocio jurídico o en ninguno, clasificándose en relativa o absoluta. Frente a la interpretación del artículo 1766 del Código Civil, la doctrina ha decantado sendas teorías, como la simulación-nulidad, la teoría dualista francesa y la monista, cada una de las cuales ha impactado en el desarrollo teórico y práctico. La carga de la prueba se problematiza en este marco, debido a la dificultad que representa para los terceros la prueba directa, ya que los hechos constitutivos de la simulación permanecen en el sigilo de los contratantes. La función del indicio como prueba por razonamiento, emerge en la jurisprudencia como mecanismo idóneo para revertir esa reserva de las partes sustanciales. Todo lo anterior, busca desarrollar el objetivo general, partiendo de la problematización planteada, en términos de describir la caracterización jurídica de la carga de la prueba en la simulación absoluta impropia.
Agricultural land use: prospects for agribusiness in the Ruzhynska territorial community
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Uliganets S. , Pasko V. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Shynkarenko U. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: December 2024

Agricultural development is an important topic in current economic and environmental debates, especially in the context of the growing global demand for food security and environmental policy implementation. Currently, many agricultural actors are working to increase the productivity of agroecosystems, which will help to fill local budgets and enable cooperation between farms and food processing companies, as well as relevant authorities. Implementation of these steps is impossible without the use of modern technologies, such as precision farming, which involves the use of remote sensing data, geographic information systems and other innovative methods that allow monitoring the state of agricultural land use. For territories with a significant share of agricultural land (arable land, pastures) in the land use system, positioning agriculture as a promising area of influence on local economic stability is a priority. As part of the study to determine the potential for agricultural development, the Ruzhynska settlement territorial community was selected as a demonstration case. To analyse the current state of the industry, data on registered agricultural processing enterprises and the existing land fund system were processed. The results showed that the agricultural sector accounts for more than 40% of the operating enterprises in the community. In addition to the economic data, the natural conditions that determine the (dis)favourable conditions for agribusiness were also taken into account. In particular, the NDVI index was calculated to identify spatial patterns of dense and sparse vegetation. The results obtained made it possible to form a comprehensive vision of the community's agricultural potential, which in the future can complement the local development strategy.
A study on the ancient urban environment of the Silla Capital based on micro-remain records
Authors:   Korean Ancient Historical Society, Ahn Sohyeon
Published: December 2024

This article suggests the possibility and direction of using biological micro-remains from archaeological sediments to reconstruct the living environment of ancient cities. It introduces case studies and issues in Gyeongju to illustrate the role and necessity of analytical research on micro-remains, such as pollen, phytoliths, diatoms, and parasitic eggs, in urban environmental studies.
The landscape changes that happened to this area during the Three Kingdoms Period to the Unified Silla Period are characterized by its transition after the 7th century to secondary forests dominated by pine trees, with lower forest density in the plains and mountains. These changes in forest ecosystems are assumed to have had a significant impact on the use of wood species for construction. While focusing simply on the scale of vegetation change tends to emphasize the clearing of forests that occurred this time, also noteworthy is the creation of 'artificial green spaces,’ such as crop production zones and landscaped zones, which the plant micro-remain records suggest to be formed within the royal capital areas.
The parasite eggs discovered from the Wolseong moat and its surrounding water- logged sediments and drainage ditch deposits suggest that water-related facilities during the Three Kingdoms Period and Unified Silla Period were infested with human feces. However, it is hard to determine the exact duration and extent that the living environment was degraded by this feces inflow into water, which requires further research in the future.
Identifying the purpose of the stone masonry features found in many Unified Silla Period sites is of interest to many researchers, but, currently, there is no micro-remains analysis data available to infer their usage as toilets. On the other hand, the significant amount of siliceous microremains identified from them suggests the possibility that they were used to store important resources, such as straw, husk or rice grains, and salt.
Risk factors of tumor lysis syndrome in childhood acute lymphoblastic leukemia
Authors: Andarsini Mia Ratwita , Hartono Audylia , Cahyadi Andi , Larasati Maria Christina Shanty , Asmara Almeir Pradhipta Andras
Published: December 2024

BackgroundAcute lymphoblastic leukemia (ALL) is the most common childhood hematologic malignancy. Treatment failure in ALL can be caused by severe and life-threatening complications, including tumor lysis syndrome (TLS). Delay in identifying risk factors and establishing the diagnosis of TLS by clinicians can be fatal. This study aimed to determine the risk factors for TLS in children with ALL.
MethodsThis was a retrospective cross-sectional study on 81 children aged 0 to 18 years with ALL. Tumor lysis syndrome comes in two forms: laboratory and clinical. Laboratory TLS occurs if uric acid levels >normal values, potassium >6mEq/L, phosphate >6.5mg/dl, and calcium <7mg/dl. Clinical TLS includes an increase in serum creatinine, the presence of heart attacks, sudden death, and seizures. Risk factors for TLS include age, nutritional status, leukocyte count, presence of organ infiltration, presence of mediastinal mass, uric acid level, renal function, and type of chemotherapy regimen. Risk factors were analyzed using simple and multiple logistic regression analyses. A value of p<0.05 indicates a significant risk factor.
ResultsTwenty seven patients (33.3%) experienced TLS. Adjusted OR analysis showed that the presence of organ infiltration (aOR 5.42; 95% CI 1.45-20.27; p=0.012), leukocyte count (aOR 8.70; 95% CI 1.67-45.13; p=0.010), and decreased kidney function (aOR 12.21; 95% CI 1.09-136.89; p=0.042) were significant risk factors for TLS.
ConclusionDecreased renal function, leukocyte count, and organ infiltration were significant risk factors for TLS. We suggest more vigilant assessment and monitoring to recognize and treat those patients who are at risk of TLS.
Ethanol extract of Abrus precatorius L. leaves diminishes inflammatory responses in nicotine-treated human gingival fibroblasts: an in vitro study
Authors: Kesumaningtias Raden Roro Widorini , Kusuma Indra , Suciati Yulia , Sari Wening
Published: December 2024

BACKGROUNDNicotine induces oxidative stress in human gingival fibroblasts (HGF) and stimulates the production of cytokines that trigger inflammation. Abrus precatorius L. (AP) leaves contain antioxidants with anti-inflammatory properties that can prevent the formation of free radicals and reduce tissue damage due to inflammation. This study aimed to determine the effect of ethanolic extract of AP leaves (EAP) on interleukin (IL-6) levels and cyclooxygenase-2 (COX-2) gene expression in gingival fibroblasts exposed to nicotine.
METHODSCells were randomized into six treatment groups and clustered into the non-treatment control group (NTC), solvent control (SC), nicotine control (NC), and groups treated with nicotine and EAP at doses of 9.375 µg/mL, 18.75 µg/mL, and 37.5 µg/mL, respectively, for 24 hours. IL-6 levels were examined using the Elisa method, while COX-2 gene expression was assessed using PCR. Data were analyzed using Oneway ANOVA and the Kruskal Wallis test.
RESULTSIL-6 levels and COX-2 expression were considerably higher in the nicotine control group. Conversely, the cell groups treated with nicotine and EAP had substantially decreased levels of both inflammatory markers IL-6 and COX-2 (p=0.029) across all EAP dose levels compared to the nicotine control group. The highest reduction in response was observed at the dose of 9.375 ìg/mL EAP.
CONCLUSIONThese results highlight the potential of Abrus precatorius L. in relieving nicotine-induced inflammation in smokers. By suppressing the production of inflammatory mediators IL-6 and COX-2 in HGF, EAP presents a promising avenue for further in vitro research.
Acute effect of five different stretching strategies on speed and agility parameters in recreationally active women
Authors: GENÇ Harun , CİĞERCİ Ali Erdem , AYDINLI İbrahim
Published: December 2024

BackgroundStretching includes movements that provide joint range of motion, increase the flexibility of muscles, joints, ligaments, and the speed of musculoskeletal communication, which are applied to increase performance in the main part of the training. Anaerobic properties are among the most important determinants of performance in athletes. Therefore, the objective of this study was to investigate the effects of five different stretching exercises on anaerobic performance (speed and agility parameters) in recreationally active women.
MethodsA study of within-subject experimental design was conducted involving 30 recreationally active females aged 23.76 ± 1.50 years. Five different protocols (NS: no stretching; SS: static stretching; DS: dynamic stretching; SDS: static + dynamic stretching; DSS: dynamic + static stretching) were used to measure performance parameters after stretching exercises. After each stretching exercise, the 10 and 20 m sprint, Illinois agility test, and reactive agility test were used to determine anaerobic performance. Repeated measures analysis of variance (ANOVA) was employed for the analysis.
ResultsA notable difference was observed in the 10 m and 20 m performance of recreationally active women after five different stretching protocols (p<0.05). When looking at the agility test values, it was found that a significant difference existed (p<0.05). DS showed the best performance in all tests.
ConclusionAccording to these results, in recreationally active women, only SS should be avoided before high or explosive exercises, or the warm-up period should include only DS, or if a combined application is to be made, DS should be applied after SS.
Risk factors of doxorubicin-induced cardiomyopathy in non-muscle- invasive bladder cancer
Authors: Sabudi I Made Nugraha Gunamanta , Hendri Ahmad Zulfan
Published: December 2024

BackgroundDoxorubicin is an anthracycline antibiotic widely used as a chemotherapeutic agent to treat solid tumors and hematologic malignancies. Bladder cancer is the second most common genitourinary malignancy and can be classified into muscle-invasive bladder cancer and non-muscle-invasive bladder cancer (NMIBC). In Indonesia, NMIBC is treated by doxorubicin instillation. Several risk factors have been suggested to be associated with doxorubicin-induced cardiomyopathy, but on their quantitative effects no consensus has as yet been reached. This study aimed to determine the risk factors of doxorubicin-induced cardiomyopathy in NMIBC patients with intravesical doxorubicin instillation.
MethodsA cross-sectional study was conducted involving 74 NMIBC patients who received local treatment by doxorubicin instillation after transurethral resection of bladder tumor (TURBT). Data were collected on the risk factors that may be favorable to doxorubicin-induced cardiomyopathy, namely age, sex, hypertension, type 2 diabetes mellitus, smoking, and NMIBC risk classification. The dependent variable was cardiomyopathy with decreasing left ventricular ejection fraction (LVEF) below 50 %. Multiple logistic regression was used to analyze the data.
ResultsThe prevalence of cardiomyopathy was 6.75% (5/74). Type 2 diabetes mellitus was a significant risk factor for doxorubicin-induced cardiomyopathy among our subjects (aOR=34.30;95% C.I.:1.36-865-86;p=0.032). In contrast, age, sex, risk classification, hypertension, and smoking were nonsignificant predictors for doxorubicin-induced cardiomyopathy (p>0.05).
ConclusionThis study demonstrated that type 2 diabetes mellitus increased the risk of cardiomyopathy in doxorubicin users among patients with NMIBC. More research is necessary regarding the mechanisms underlying type 2 diabetes mellitus as a risk factor for doxorubicin-induced cardiomyopathy.
Comparison of natural versus artificial cycles for endometrial preparation prior to frozen embryo transfer
Authors: Tyagitha Galuh Anindya , Nuryanto Kartiwa Hadi , Pratama Gita , Maidarti Mila , Harzif Achmad Kemal , Sumapraja Kanadi , Lestari Silvia Werdhy , Ampri Irfan Arieqal Hatta , Talya Natasha , Yanfaunas Atika Mahira
Published: December 2024

BackgroundThe endometrial preparation phase preceding embryo transfer assumes pivotal significance in achieving optimal endometrial receptivity and ensuring the success of pregnancy. The natural cycle (NC) and artificial cycle (AC) are the preferred methods for many in vitro fertilization (IVF) specialists. The objective of this study was to compare the difference between NC and AC in women undergoing frozen-thawed embryo transfer (FET) after IVF.
MethodsA cross-sectional study was conducted involving 150 adult women who underwent FET with a single autologous blastocyst stage embryo in a 5-year period (2014-2019). Bivariate analysis was conducted to discern implantation and pregnancy rates associated with NC and AC for endometrial preparation. Multiple logistic regression was used to assess the association between endometrial preparation and clinical outcomes while adjusting for potential confounders.
ResultsOf the 150 subjects meeting study criteria, 19 underwent NC, while 131 underwent AC for endometrial preparation. Natural cycle exhibited a higher biochemical pregnancy rates compared to AC (89.5% vs. 53.4%; p=0.003). Artificial cycle is a significant determinant for biochemical pregnancy rates compared to NC (aOR: 0.132;95% CI: 0.028 – 0.623; p=0.010)
ConclusionIn women undergoing FET, NC resulted in higher biochemical pregnancy rates compared to AC. However, clinical pregnancy rates and ongoing pregnancies rates did not exhibit significant disparities between NC and AC. Future studies will hopefully further illuminate which protocol is most suitable for the individual patient. Further multi-center randomized clinical trials are needed to confirm the relationship between biochemical pregnancy rates and NC.
Relationship between presenting symptoms and tumor location in colorectal cancer patients
Authors: Ismida Fitri Dewi , Maghfirah Desi , Salam Nurbahri L , Yusuf Fauzi , Mulia Vera Dewi , Purnomo Avisena Gatot
Published: December 2024

BackgroundColorectal cancer (CRC) often shows symptoms at an advanced stage, causing delayed diagnosis and poorer prognosis. Initial symptoms, or chief complaints, are usually identified through patient history and can vary based on tumor location. This can help in establishing a diagnosis. This study aimed to determine the relationship between presenting symptoms and tumor location in CRC patients at Zainoel Abidin Regional General Hospital, Banda Aceh.
Methods This cross-sectional study was conducted using secondary data from medical records (2019–2022) for 163 CRC patients. Information on symptoms of patients were collected from patient files: anemia, anorexia, diarrhea, constipation, abdominal pain, rectal bleeding, and palpable abdominal mass. Tumor locations were classified as right colon, left colon, rectum, and left colon plus rectum. Bivariate analysis was used to analyze the data.
Results Of the 163 patients, 98 (58%) were aged e”50 years, 82 (50.3%) were male, and 99 (60.7%) had rectal tumors. The percentage of patients presenting with rectal bleeding was significantly higher in rectal cancers (47.47%) as compared with cancers in the left colon (28.57%) and left colon and rectal (33.33%) cancers (p=0.000). The percentage of patients presenting a palpable abdominal mass was significantly higher in right colon (31.58%) compared with left colon (4.76%) and rectal cancer (1.01%) (p=0.000).
ConclusionsTumor location in the right colon is associated with palpable abdominal mass, while rectal location is associated with rectal bleeding in CRC patients. Familiarity with clinical symptoms of CRC could make patients more sensitive to undergo more frequent screening for cancer.
Evaluating sarcopenia prevalence and relationship with disease activity of primary Sjögren syndrome in females
Authors: Başaran Pınar Özge , Eker Büyükşireci Dilek
Published: December 2024

BackgroundPrimary Sjögren’s syndrome (pSS) leads to impaired muscle function and mass as well as pain and fatigue. Sarcopenia is the pathological reduction of skeletal muscle mass and strength. We aimed to investigate the prevalence of sarcopenia and determine its relationship with disease activity levels in females with primary Sjögren syndrome.
MethodsThis cross-sectional study was performed on 62 female patients diagnosed with pSS and 62 female age matched healthy controls. Disease activity was evaluated with the EULAR Sjögren’s syndrome patient reported index (ESSPRI) and EULAR Sjögren’s syndrome disease activity index (ESSDAI), fatigue severity scale (FSS), hospital anxiety and depression scale (HADS), and numerical rating scale (NRS). A simple questionnaire to rapidly diagnose sarcopenia (SARC-F) was used to screen for sarcopenia. Degree of sarcopenia was evaluated by handgrip strength, anterior thigh muscle thickness by USG, the 6-meter walk test (6MWT), and the five times sit-to-stand test (FTSST).
ResultsThe prevalence of sarcopenia was found to be 36/62 (58.1%) in pSS and 6/62 (9.7%) in healthy controls (p<0.001). HADS anxiety and depression scores and SARC-F scores were significantly higher in pSS (p<0.001). There were significant differences in 6MWT, FTSST, and hand grip strength results in pSS (p<0.001). Anterior thigh muscle thickness was similar in both groups (p=0.298). A positive correlation was found between SARC-F on the one hand and ESSPRI and NRS on the other (r=0.595, p=0.009; r=0.569, p=0.014).
ConclusionSarcopenia prevalence was increased in female patients with pSS and there was a relationship of SARC-F scores with pain and disease activity levels.
Editors' Introduction
Authors: Grushkin Donald , Brune Jeff
Published: December 2024

No abstract available.
Where Can I Sign My Language?: A Systematic Literature Review (2000–2019) of Young People's Access to Sign Language Socialisation Spaces in the Nordic Countries
Authors: Haualand Hilde , Hjulstad Johan , Ingjerd Legreid Ødemark  , Kermit Patrick
Published: December 2024

This article presents the results from a systematic literature review of Nordic research studies from 2000 to 2019, addressing the question of children and adolescents' access to spaces where they can sign with peers and adults. The study is based on a dialogistic approach to language, and holds that languaging is inextricably tied to places and situations—that is, spaces and contexts in which people participate in interactions with others. Thus, acquiring sign language is not only about the child or adolescent's individual learning of sign language in an educational setting, but also about participation in sign language activities. The review addresses the paradoxical situation in the field of sign language education whereby formal recognition of sign language and the institutionalisation of rights to sign language education gained momentum at around the same time as the number of deaf schools began to decline. The results from the review indicate that very few studies of sign language pay attention to spaces where children and adolescents can interact with other people through sign language. It appears that current legislation, as well as research, emphasises the individual right to learn sign language for deaf and hard-of-hearing children, and has overlooked the significance of facilitating and protecting sign language-based socialisation spaces as significant sites for sign language learning, participation and acquisition.
Personalized approach to the biologicals’ selection in patients with severe asthma: real practice tools and new possibilities
Authors: Pavlova K. S. , Timoshenko D. O. , Osokin A. A. , Kofiadi I. A. , Kurbacheva O. M.
Published: December 2024

Currently, the most effective approach to treating patients with severe uncontrolled asthma is the use of biologicals. These treatments are highly effective and safe, but not universal. Different biologicals block various parts of asthma pathogenesis. Also, biologicals have different effectiveness in relation to comorbidities. In this regard, the targeted therapy selection should be personalized, endotypeand phenotype-oriented.

The aim of this review was to analyze the literature data on methods for personalized biologicals’ selection in patients with severe asthma that are currently used in clinical practice, as well as new prospects in this area.

Conclusion. Laboratory and instrumental examination methods currently used for endoand phenotyping of severe asthma help in identifying the key pathogenetic factor in the disease development that serves as a basis for selection of the biological. However, biomarkers identified during routine examination are not absolute and are prone to exceptions. Also, the targeted therapy selection is based on a subjective determination of the prevailing pathogenetic mechanism when a patient with severe asthma has a mixed disease phenotype and meets the criteria for prescribing all available biologicals. Therefore, the search for biomarkers that predict the effect of a particular biological remains a relevant direction for future studies. The combined use of clinical, molecular-genetic examination results and evaluation of epigenetic markers can help in solving this problem. This review provides current data on the biologicals used in severe asthma treatment, the phenotyping and endotyping tools used in real practice, and also describes promising areas of the epigenetic biomarkers research.
Analysis of the incidence, disability and mortality rates of the Russian population due to respiratory diseases and COVID-19 in the period 2016 – 2021
Authors: Bystritskaya E. V. , Bilichenko T. N. , Misharin V. M.
Published: December 2024

High incidence of respiratory diseases (RD) makes monitoring of the associated morbidity and mortality in the Russian population important for the public health.

The aim was to study the incidence, disability and mortality rates associated with RD in 2016 – 2021 by federal districts of Russian Federation.

Methods. Statistical data from the Ministry of Healthcare of the Russian Federation and Federal State Statistics Service was used.

Results. There was an increase in the RD morbidity by 12.0% from 2019 to 2021 (from 40,694.7 to 45,560.7 per 100 thousand population, p < 0.001), and a 3-fold increase in the incidence of pneumonia. The RD incidence increased in all federal districts, with the maximum in the Northwestern Federal District (2021 – 55,680.9 per 100 thousand population). An increase in the RD-associated mortality rates (MR) by 95.8% was recorded from 2019 to 2021: from 40.3 to 78.7 deaths per 100,000 population. In 2021, the proportion of pneumonia in the structure of MR was 65.3%, and the hospital mortality due to RD increased. The proportion of people with primary disability due to RD decreased in 2021. The COVID-19 (COronaVIrus Disease 2019) incidence rate has been registered since 2020 (2020 – 3,391.1, 2021 – 8,085.7 cases per 100 thousand population). The MR associated with COVID-19 reached 98.8 per 100,000 population in 2020 and 319.1 per 100,000 population in 2021.

Conclusion. In the period 2019 – 2021, there were an increase in the RD incidence in the Russian population, mostly due to pneumonia. The RD incidence and pneumonia incidence reached the maximum in 2021, which required expansion of the healthcare capacities at short notice.
Registry as a tool for monitoring effectiveness of immunobiological therapy for severe asthma in real clinical practice
Authors: Naumova V. V. , Kiseleva D. V. , Zykov K. A. , Beltyukov Е. К. , Klyachina E. S. , Nikiforova I. O. , Suvorkov P. A.
Published: December 2024

Registry is a unique and universal mechanism for group and individual approaches to managing patients, including those with severe asthma (SA) who require targeted therapy.

The aim is to evaluate the clinical and organizational potential of the SA patient registry as a tool for group and individual approaches to patient management, as a way to describe and systematize the signs of bronchial asthma, comorbid diseases, and monitoring immunobiological therapy (using anti-IgE therapy as an example) in patients with SA in Sverdlovsk region.

Methods. The subject of the study was the Territorial Registry of Patients with SA of the Sverdlovsk region. The registry effectiveness was assessed based on the clinical and organizational indicators, including monitoring the effectiveness of 3-year anti-IgE therapy in patients with SA with an allergic component.

Results. From 2016 to 2023, both inclusive, 198 patients with SA were entered into the registry. Analysis of the registry data allowed us to develop a scheme for SA phenotyping and selecting the 1st and 2nd line targeted drugs and a scheme for phenotyping and selecting a targeted drug for T2 inflammatory nasal diseases. Over 3 years of anti-IgE therapy with omalizumab, the ACT test increased from 9.00 to 19.50 points, the proportion of patients with partial and good asthma control increased by 13.89 times, the frequency of exacerbations decreased by 71.43%, FEV1 increased by 17.91%, and the proportion of patients requiring systemic corticosteroids decreased by 83.32%.

Conclusion. The registry of SA patients has high clinical and organizational potential to describe and systematize the signs of bronchial asthma, comorbid diseases, and monitor the effectiveness and safety of immunobiological therapy. The 3-year anti-IgE therapy demonstrates statistically significant effectiveness in patients with SA with an allergic component.
Understanding Student Performance in Foundation Year: Insights from Logistic Regression, Naïve Bayes, and Random Forest Models
Authors:   Department of Basic Sciences, Deanship of Preparatory Year and Supporting Studies, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Musa Abdallah Bashir
Published: December 2024

Foundation programs enhance students’ essential skills, equip them for degree programs, and impact academic performance, retention, and intrinsic motivation. Previous studies focused mostly on demographic factors and statistics. Limited literature has focused on students’ performance in the foundation year. This study uses machine learning techniques to investigate the factors influencing foundation year students’ performance. The study assesses 22 predictor factors, including demographics, secondary school achievement, language proficiency, and university experiences, using Logistic Regression (LR), Naïve Bayes (NB), and Random Forest (RF) algorithms. The study’s findings revealed that gender, school type, secondary school scores, desired college major, and English and math proficiency levels were the significant determinants of students’ performance in their foundation year. Random Forest (RF) showed higher accuracy than both Naïve Bayes (NB) and Logistic Regression (LR). The study indicated that identifying performance factors can improve support services by maximizing learning and results via data-driven methodologies. In conclusion, this study revealed the potential of machine learning in evaluating student performance determinants, supporting targeted interventions, and individualized training through advanced machine learning algorithms and longitudinal data. Moreover, the study helps predict students’ performance in the second semester. Consequently, it projects the enrollment figures for each college along with the anticipated dropout rates.
Advancing dental implantology with phototherapy: A comparative review of photobiomodulation and photodynamic therapies
Authors: Selvam Divyabharathi , Rengasamy Venkat , Vasudevan Karthikeyan
Published: December 2024

This review examines the roles of phototherapy such as Photobiomodulation Therapy (PBMT) and Photodynamic Therapy (PDT) in the field of implantology, assessing their benefits, limitations, and clinical applications. PBMT has emerged as a promising adjunctive treatment, offering benefits such as enhanced tissue healing, improved implant stability, and reduced postoperative discomfort through stimulation of cellular processes. However, inconsistencies in treatment protocols and the need for more comprehensive long-term studies underscore the need for standardized approaches. PDT, on the other hand, shows efficacy in managing peri-implantitis by targeting bacterial infections with photosensitizers and light. Despite its potential, challenges such as incomplete bacterial eradication suggest a need for further refinement and integration with mechanical debridement. The review highlights the necessity for developing standardized treatment protocols, conducting extended research, and exploring combination therapies to optimize the application of PBMT and PDT in implantology. Future investigations should focus on these areas to enhance clinical outcomes and establish best practices in implant therapy.
Beauty beyond numbers: The golden ratio and facial aesthetics
Authors: Vincent Divya , Nazar Jincy , Abraham George Varghese , Philip Rony
Published: December 2024

Facial aesthetics encompasses studying facial features and proportions to understand what makes a face visually appealing. The Golden Ratio refers to a mathematical proportion of 1.618, has been compared since ages for its aesthetic harmony and has been known to play a major role in defining ideal facial proportions. The Golden Ratio is used in assessing facial symmetry and proportionality across all cultures and populations. The implications of using the Golden Ratio in fields like digital imaging, cosmetic surgery and art, and its role in shaping perceptions of beauty. By using historical insights with modern research, this article provides an outline of the relationship between facial aesthetics and the Golden Ratio, thereby emphasizing both the theoretical foundations and practical implications of the theory in the study of beauty.
Beam of hope: Laser therapy for peripheral ossifying fibroma
Authors: Purohit Janhavi Nikhil , Indurkar Maya Sanjiv
Published: December 2024

Peripheral ossifying fibroma (POF) is a reactive non-neoplastic gingival overgrowth. It is reactive overgrowth originating from periodontal ligament cells. POF occurs frequently in the maxillary anterior region. The lesion has female predilection. POF has high recurrence rate. Various treatment modalities are available to excise POF including scalpel, electrocautery, cryotherapy & laser. It is a case report of 48 year old female patient with POF in the left palatal region and one-year follow-up after excision done using Er: YAG laser.
Intracranial lesions: Histopathological and radiological correlation
Authors: Chag Shyama Manojkumar , Chaudhari Suraj Karshanbhai , Chaudhari Sanjay Namdev
Published: December 2024

Intracranial space-occupying lesions (ICSOLs) include neoplastic and non-neoplastic lesions of the central nervous system. “In India, central nervous system neoplasms account for approximately 1.9% of all malignant tumours.” Biopsy and histopathology are essential for accurate diagnosis and preventing incorrect therapeutic interventions.

The study aims to correlate histopathological and radiological diagnosis of intracranial lesions. Epidemiological parameters of various neoplastic and non-neoplastic intracranial lesions according to age, sex and site are assessed.

The retrospective and prospective descriptive study, conducted at the tertiary care centre, analysed 104 cases of ICSOLs. The study utilised preoperative radiological reports, MRI (Primarily) or CT scan. The statistical analysis was performed using STATA (14.2). Frequencies and the chi-square test were used for calculation.

In the present study, neoplastic lesions (93.27%) were more common than non-neoplastic lesions (6.73%), with a male predominance (Male: Female = 1.36:1). Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of radiological diagnosis in neoplastic lesions were 98.97%, 28.57%, 95.04%, 66.67% and 94.23% respectively, compared to histopathological diagnosis. P-value <0.05 suggests statistically significant results.

The study found a higher incidence of neoplastic intracranial lesions, likely due to the institute's fully functional oncology department. Radiological techniques offer non-invasive insights into lesion characteristics, while histopathological examination provides a definitive cellular-level diagnosis. Together, these methods enhance diagnostic accuracy, guide treatment decisions, and improve patient outcomes.
Atypical stromal cells, a pseudosarcomatous change in sinonasal polyp causing diagnostic dilemma - A case report and review of literature
Authors: Radhika S , Lakshmi Selva Guru , Saranya M , Preethi G Rajalakshmi
Published: December 2024

Nasal polyposis is a commonly encountered non-neoplastic inflammatory disease of the nose and paranasal sinuses presenting with various clinical manifestations like nasal obstruction, rhinorrhea, headache, anosmia/hyposmia, etc. The two most common etiologies of nasal polyps includes allergy and infections. The incidence of nasal polyposis in the general population is 0.5 to 4%. The histological diagnosis of benign inflammatory polyps of the nasal cavity usually doesnot pose any diagnostic difficulties. However, certain unusual histological features can be observed rarely which might be a huge challenge to the pathologists as they can mimic sarcoma. We hereby present one of the unusual feature - atypical stromal cells in a nasal polyp which we came across during histopathological examination of an antrochoanal polyp from a 34 year old female who presented with bilateral nasal obstruction. Pathologists and clinicians must be well aware of this entity, though they are rare. A better understanding of this entity - atypical stromal cells in a benign inflammatory polyp can help in preventing an erroneous diagnosis of sarcoma, thereby preventing unnecessary treatment and anxiety to the patient.