bluuebunny/crossref_metadata_2025 huggingface dataset:
Perioperative Blood Loss Can Be Reduced If Total Knee Arthroplasty Was Performed in the Si Hour-Period, Compared with the Wei Hour-Period: A Retrospective Cohort Study
Authors: Wang Xiaojian , Xu Ting , Wang Rui , Wang Penghe , Jin Shuaijie , Tong Peijian , Lv Shuaijie
Published: August 2021

Objective. To investigate the efficacy and safety of performing primary unilateral total knee arthroplasty (TKA) in the “Si hour-period” meaning 09:00 a.m. to 11:00 a.m. (one of the 12 two-hour periods into which the day was traditionally divided, each being given the name of one of the 12 earthly branches), compared with the “Wei hour-period” (13:00–15:00). Methods. Patient documentations were studied for those who underwent a primary unilateral TKA performed by the same surgical team with a tourniquet between January 2018 and January 2021 at our medical center. Eighty-four patients were enrolled and assigned into group A (in Si hour-period) and group B (in Wei hour-period). The main outcomes were total blood cell loss (TBL), hidden blood loss (HBL), visible blood loss (VBL), maximum hemoglobin (Hb) drop, and transfusion rate. Secondary outcomes were length of hospital stay (LOS), postoperative femorotibial mechanical axis (FTMA), FTMA correction, platelet count, plasma D-dimer (D-D), prothrombin time (PT), international normalized ratio (INR), and the incidence of postoperative complications. Results. Group A showed statistical significance lower at the mean TBL, the mean HBL, and the maximum Hb drop (95% CI: −352.8 to −46.1,

P
=
0.011

, 95% CI: −348.0 to −40.1,

P
=
0.014

, and 95% CI: −9.5 to −0.7,

P
=
0.023

, respectively) after TKA than group B. The postoperative platelet count of group A was more significant than that of group B (95% CI:3.1 to 52.9,

P
=
0.028

). The VBL, transfusion rate, the LOS, postoperative FTMA, FTMA correction, plasma D-D, PT, INR, and the incidence of postoperative complications (wound complications, calf muscular vein thrombosis, infection, pulmonary embolism, and deep vein thrombosis) were similar between the two groups (

P
>
0.05

, respectively). Conclusion. Our study shows that blood loss can be reduced when TKA is performed in the “Si hour-period,” which may be due to increasing platelet count, and postoperative complications did not increase, compared with the Wei hour-period. We recommend that the selective operation, such as TKA, should be performed in the “Si hour-period” in clinical practice between the two hour-period.
Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression
Authors: Gäbel Gabor , Northoff Bernd H. , Balboa Amanda , Becirovic‐ Agic Mediha , Petri Marcelo , Busch Albert , Maegdefessel Lars , Mahlmann Adrian , Ludwig Stefan , Teupser Daniel , de Waard Vivian , Golledge Jonathan , Wanhainen Anders , Wågsäter Dick , Holdt Lesca M. , Lindeman Jan H. N.
Published: August 2021

Background

While numerous interventions effectively interfered with abdominal aortic aneurysm (AAA) formation/progression in preclinical models, none of the successes translated into clinical success. Hence, a systematic exploration of parallel and divergent processes in clinical AAA disease and its 2 primary models (the porcine pancreatic elastase and angiotensin‐II infusion [AngII] murine model) was performed to identify mechanisms relevant for aneurysm disease.

Methods and Results

This study combines Movat staining and pathway analysis for histological and genomic comparisons between clinical disease and its models. The impact of a notable genomic signal for metabolic reprogramming was tested in a rescue trial (AngII model) evaluating the impact of 1‐(4‐pyridinyl)‐3‐(2‐quinolinyl)‐2‐propen‐1‐one (PFK15)‐mediated interference with main glycolytic switch PFKFB3. Histological evaluation characterized the AngII model as a dissection model that is accompanied by adventitial fibrosis. The porcine pancreatic elastase model showed a transient inflammatory response and aortic dilatation, followed by stabilization and fibrosis. Normalization of the genomic responses at day 14 confirmed the self‐limiting nature of the porcine pancreatic elastase model. Clear parallel genomic responses with activated adaptive immune responses, and particularly strong signals for metabolic switching were observed in human AAA and the AngII model. Rescue intervention with the glycolysis inhibitor PFK15 in the AngII model showed that interference with the glycolytic switching quenches aneurysm formation.

Conclusions

Despite clear morphological contrasts, remarkable genomic parallels exist for clinical AAA disease and the AngII model. The metabolic response appears causatively involved in AAA progression and provides a novel therapeutic target. The clear transient genomic response classifies the porcine pancreatic elastase model as a disease initiation model.
The Intersection of Type 2 Myocardial Infarction and Heart Failure
Authors: McCarthy Cian P. , Jones‐O’Connor Maeve , Olshan David S. , Murphy Sean , Rehman Saad , Cohen Joshua A. , Cui Jinghan , Singh Avinainder , Vaduganathan Muthiah , Januzzi James L. , Wasfy Jason H.
Published: August 2021

Background

Type 2 myocardial infarction (T2MI) is common and associated with high cardiovascular event rates. However, the relationship between T2MI and heart failure (HF) is uncertain.

Methods and Results

We identified patients with T2MI at a large tertiary hospital between October 2017 and May 2018. Patient characteristics, causes of T2MI, and subsequent HF hospitalizations were determined by physician chart review. We identified 359 patients with T2MI over the study period; 184 patients had a history of HF. Among patients with ejection fraction (EF) assessment (N=180), the majority had preserved EF (N=107; 59.4%), followed by reduced EF (N=54; 30.0%), and mid‐range EF (N=19; 10.6%). Acute HF was the most common cause of T2MI (20.9%). Of those whose T2MI was precipitated by HF (N=75), the mean EF was 53.0±16.8% and 16 (21.3%) were de novo diagnoses of HF. Among patients with T2MI who were discharged alive with available follow‐up (N=289), 5.5% were hospitalized with acute HF within 30 days, 17.3% within 180 days, and 22.1% within 1 year. In subgroup analyses, among patients with T2MI with prevalent or new HF (N=161), the rate of HF hospitalization at 1 year was 34.2%, considerably higher than those with T2MI and no HF diagnosis at discharge (7.0%; N=9/128).

Conclusions

Index presentations of HF or worsening chronic HF represent the most common causes of T2MI. ≈1 in 5 patients with T2MI will be readmitted for HF within 1 year of their event. Strategies to prevent HF events after a T2MI are needed.
“Still Holding the Pipa to Hide Half Her Face”: Visions of Bai Juyi’s ‘Song of the Pipa’ in Republican China
Authors: Estep Chloe
Published: August 2021

A recurring subject of manhua (comics) in Republican-era China was the pipa player, a woman whose genealogy can be traced back to the disgraced and displaced subject of Bai Juyi’s ninth-century poem Pipa xing (Song of the pipa). This paper traces this woman’s development from her conception in Pipa xing and follows her as she is re-imagined by modern poets and manhua artists into a variety of figures, from scorned politicians to modern feminine archetypes.

This paper argues that these artists leverage her precarity and anachronism to portray contemporary political turmoil and national insecurity, as they look back at China’s imperial past and towards its uncertain future. And instead of reifying the distinction between the prosody of classical and New Poetry, this paper finds classical poetics not only in poems themselves, but also in tropes and images that reveal how poets and poetry reckoned with the rise of new media.
Conflicting Masculinities in Ha Jin’s Waiting: Talented Scholars and Ruthless Men of Action in China’s Mao and Post-Mao Eras
Authors: Su Lezhou , Hird Derek
Published: August 2021

As a highly acclaimed novel for which Ha Jin won the U.S. National Book Award in 1999, Waiting covers the period from the early 1960s to the early 1980s, encompassing the Cultural Revolution through the early reform era. Its oft-noted central concern is the suppression of emotional life, and by extension humanity, in the totalitarian climate of Mao’s regime. This article offers a new reading, which foregrounds the novel’s use of masculinities as a central theme and driver of the plot. Through the prism of Kam Louie’s wen-wu (literary accomplishment – military prowess) dyad, this study focuses on Ha Jin’s critique of the socialist-era trajectories of two historically prominent Chinese male character types: the intellectually-oriented man of book learning and the physically-driven man of action. It shows how Waiting illuminates the conditions underlying a pervasive social and psychological paralysis of male intellectuals and the contrasting empowerment of a predatory class of nouveau riche entrepreneurs.
Leftover Men and Masculine Grievance: Making Sense of Rural Migrant Men’s Emotional Hardships
Authors: Sun Wanning
Published: August 2021

The social problem of “leftover men” among the most marginalized members of China’s rural migrant population has become widely known, but how these rural migrants themselves talk about and make sense of their failures to secure a marriage partner is relatively less understood. Answering this question may also shed light on how socioeconomic marginalization makes an impact on rural migrant men’s masculine identity. This paper is a longitudinal study of a cohort of unmarried rural migrant men born in the 1980s. This study shows that the emotional experience of cohort members is marked by a mixture of persistent feelings of loneliness, bitterness, and dissatisfaction with the status quo of their lives, and a quiet yearning for the possibility – however remote – of “finding someone” in the future. The paper also points to “masculine grievance” as a useful concept for understanding how unmarried migrant men rationalize their emotional hardships.
The Necessity of Community Collaborations in Supporting Newcomer Student Learning: Lessons Learned from the covid-19 Pandemic
Authors: Pillay Thashika , Ghahari Setareh , Xavier Merin Shobhana , Wali Halima , James Suchetan , Sani Muhammad H. , Alexander Libby
Published: August 2021

This article captures the results of a study illustrating the challenges experienced by newcomer youth to Canada in adapting to online learning between March and June 2020. A collaborative research team consisting of a local immigrant-serving agency, local school board and educators, and a group of interdisciplinary university researchers conducted a qualitative study to explore educational challenges from the perspectives of high school-aged youth and parents of elementary school students. We found that the covid-19 crisis exposed the fissures in the education system whereby those most in need of the supposed support offered by the education system were not intentionally included in organizational policies and procedures, thus further exacerbating educational inequities and compounding the pre-Covid challenges students experienced. This study also models collaborative and community-centred research on how educators and school boards could work with community supporting agencies to provide support for newcomer youth during and beyond the Covid-19 pandemic.
Combating Anti-Asian Racism and Xenophobia in Canada: Toward Pandemic Anti-Racism Education in Post-covid-19
Authors: Guo Shibao , Guo Yan
Published: August 2021

Canada is often held up internationally as a successful model of immigration. Yet, Canada’s history, since its birth as a nation one hundred and fifty-four years ago, is one of contested racial and ethnic relations. Its racial and ethnic conflict and division resurfaces during covid-19 when there has been a surge in racism and xenophobia across the country towards Asian Canadians, particularly those of Chinese descent. Drawing on critical race theory and critical discourse analysis, this article critically analyzes incidents that were reported in popular press during the pandemic pertaining to this topic. The analysis shows how deeply rooted racial discrimination is in Canada. It also reveals that the anti-Asian and anti-Chinese racism and xenophobia reflects and retains the historical process of discursive racialization by which Asian Canadians have been socially constructed as biologically inferior, culturally backward, and racially undesirable. To combat and eliminate racism, we propose a framework of pandemic anti-racism education for the purpose of achieving educational improvement in post-covid-19.
Embracing a Practice of Care During Challenging Times: Voices of Social Justice Leaders
Authors: Niño Juan Manuel
Published: August 2021

In an attempt to mitigate community spread of covid 19, many school districts cancelled face to face sessions and shifted to online instruction. As communities enacted quarantines, schools were pressed to transition learning environments to students’ homes while policymakers and leaders implemented a number of new policies and procedures. The purpose of this study explored how the covid 19 transformed the leadership of educators in three southwest Texas school districts when instruction was modified to e-learning. This qualitative study centered on the accounts and experiences of 25 elementary and secondary educators from 3 different Title I school districts in southwest Texas. The participants were graduate students in a nationally recognized program for the development of social justice leaders. As a result, this study uncovered how the practice of these educational leaders evolved to serve the Latino students in their communities. This study will highlight how the teachers’ agency helped leverage services to provide the learning opportunity for the learners.
Pausing for Answerability: A Critical Investigation of U.S. Assessment and Accountability Decisions Amidst the covid-19 Pandemic
Authors: Carter Cee , Mcintee Kimberly
Published: August 2021

This paper takes up Leigh Patel’s (2016) methodological stance of pausing to consider how and whether the U.S. federal government’s theory of educational change, or their plan for educational equity and accountability, is answerable to Black, Indigenous, and students of color in the context of the global pandemic, the switch to remote learning, and global uprisings for Black lives. To discuss the federal government’s current theory of educational change, we (the authors) conducted a policy document review, outlining the U.S.’s educational response(s) to the ongoing global health crisis. The paper reports on current federal law requirements and waivers for: assessments, accountability, reporting, and school identification. We also discuss how the federal educational response is limited for addressing the context and learning of Black, Indigenous and students of color. We practice answerability by positing alternative approaches for educational policymaking in the age of covid-19.
Unpacking the Status-Leveling Burden for Women in Male-Dominated Occupations
Authors: Cardador M. Teresa , Hill Patrick L. , Salles Arghavan
Published: August 2021

The challenges faced by women in male-dominated occupations are often attributed to the men in, and masculine cultures of, these occupations—and sometimes to senior women in these occupations who may fail to give a “leg up” to the women coming up behind them. As such, prior research has largely focused on challenges that women experience from those of higher or equal status within the occupation and on the negative climate that surrounds women in these positions. We introduce a novel challenge, the status-leveling burden, which is the pressure put on women in male-dominated occupations from women in occupations lower in the institutional hierarchy to be their equal. Drawing on interviews with 45 surgeons, we present a model that unpacks this status-leveling burden. Our research makes novel contributions to the literatures on challenges to women in male-dominated occupations and on shared demography in cross-occupational collaboration, and it suggests new avenues for research at the intersection of gender and occupational status in the workplace.
Racial Discrimination in Housing: How Landlords Use Algorithms and Home Visits to Screen Tenants
Authors: Rosen Eva , Garboden Philip M. E. , Cossyleon Jennifer E.
Published: August 2021

An extensive literature documents racial discrimination in housing, focusing on its prevalence and effect on non-White populations. This article studies how such discrimination operates, and the intermediaries who engage in it: landlords. A fundamental assumption of racial discrimination research is that gatekeepers such as landlords are confronted with a racially heterogeneous applicant pool. The reality of urban housing markets, however, is that historical patterns of residential segregation intersect with other structural barriers to drive selection into the applicant pool, such that landlords are more often selecting between same-race applicants. Using interviews and observations with 157 landlords in four cities, we ask: how do landlords construct their tenants’ race within racially segmented housing markets, and how does this factor into their screening processes? We find that landlords distinguish between tenants based on the degree to which their behavior conforms to insidious cultural narratives at the intersection of race, gender, and class. Landlords with large portfolios rely on screening algorithms, whereas mom-and-pop landlords make decisions based on informal mechanisms such as “gut feelings,” home visits, and the presentation of children. Landlords may put aside certain racial prejudices when they have the right financial incentives, but only when the tenant also defies stereotypes. In this way, landlords’ intersectional construction of race—even within a predominantly Black or Latino tenant pool—limits residential options for low-income, subsidized tenants of color, burdening their search process. These findings have implications for how we understand racial discrimination within racially homogenous social spheres. Examining landlords’ screening practices offers insight into the role housing plays in how racism continues to shape life outcomes—both explicitly through overt racial bias, and increasingly more covertly, through algorithmic automation and digital technologies.
Above and Beyond Age: Prediction of Major Postoperative Adverse Events in Head and Neck Surgery
Authors: Mascarella Marco A. , Muthukrishnan Nikesh , Maleki Farhad , Kergoat Marie-Jeanne , Richardson Keith , Mlynarek Alex , Forest Veronique-Isabelle , Reinhold Caroline , Martin Diego R. , Hier Michael , Sadeghi Nader , Forghani Reza
Published: August 2021

Objective:

Major postoperative adverse events (MPAEs) following head and neck surgery are not infrequent and lead to significant morbidity. The objective of this study was to ascertain which factors are most predictive of MPAEs in patients undergoing head and neck surgery.

Methods:

A cohort study was carried out based on data from patients registered in the National Surgical Quality Improvement Program (NSQIP) from 2006 to 2018. All patients undergoing non-ambulatory head and neck surgery based on Current Procedural Terminology codes were included. Perioperative factors were evaluated to predict MPAEs within 30-days of surgery. Age was classified as both a continuous and categorical variable. Retained factors were classified by attributable fraction and C-statistic. Multivariate regression and supervised machine learning models were used to quantify the contribution of age as a predictor of MPAEs.

Results:

A total of 43 701 operations were analyzed with 5106 (11.7%) MPAEs. The results of supervised machine learning indicated that prolonged surgeries, anemia, free tissue transfer, weight loss, wound classification, hypoalbuminemia, wound infection, tracheotomy (concurrent with index head and neck surgery), American Society of Anesthesia (ASA) class, and sex as most predictive of MPAEs. On multivariate regression, ASA class (21.3%), hypertension on medication (15.8%), prolonged operative time (15.3%), sex (13.1%), preoperative anemia (12.8%), and free tissue transfer (9%) had the largest attributable fractions associated with MPAEs. Age was independently associated with MPAEs with an attributable fraction ranging from 0.6% to 4.3% with poor predictive ability (C-statistic 0.60).

Conclusion:

Surgical, comorbid, and frailty-related factors were most predictive of short-term MPAEs following head and neck surgery. Age alone contributed a small attributable fraction and poor prediction of MPAEs.

Level of evidence:

3
Mortality in dementia is predicted by older age of onset and cognitive presentation
Authors: Loi Samantha M , Tsoukra Paraskevi , Chen Zhiben , Wibawa Pierre , Mijuskovic Tamara , Eratne Dhamidhu , Di Biase Maria A , Evans Andrew , Farrand Sarah , Kelso Wendy , Goh Anita MY , Walterfang Mark , Velakoulis Dennis
Published: August 2021

Objectives:

Survival information in dementia is important for future planning and service provision. There have been limited Australian data investigating survival duration and risk factors associated with mortality in younger-onset dementia.

Methods:

This was a cross-sectional retrospective study investigating survival in inpatients with a diagnosis of dementia admitted to a tertiary neuropsychiatry service from 1991 to 2014. The Australian Institute of Health and Welfare National Death Index was used to obtain mortality information.

Results:

A total of 468 inpatients were identified, of which 75% had symptom onset at ⩽65 years of age (defined as younger-onset dementia). Dementia was categorised into four subtypes, Alzheimer’s dementia, frontotemporal dementia, vascular dementia and other dementias; 72% of the patients had died. Overall median survival duration was 10.6 years with no significant differences in duration within the dementia subtypes ( p = 0.174). Survival in older-onset dementia (symptom onset at >65 years of age) was about half of that in younger-onset dementia (median survival 6.3 years compared to 12.7 years, respectively). Independent predictors of mortality were having older-onset dementia (hazard ratio: 3.2) and having initial presenting symptoms being cognitive in nature (hazard ratio: 1.5). Females with an older-onset dementia had longer survival compared to males with an older-onset dementia, and this was reversed for younger-onset dementia. Older-onset dementia and younger-onset dementia conferred 3 and 6 times, respectively, increased risk of death compared to the general population.

Conclusion:

This is the largest Australian study to date investigating survival and risk factors to mortality in dementia. We report important clinical information to patients with dementia and their families about prognosis which will assist with future planning. Our findings suggest that for both older-onset dementia and younger-onset dementia, ‘new onset’ psychiatric symptoms precede the cognitive symptoms of a neurodegenerative process. This, and sex differences in survival depending on the age of onset of the dementia warrant further investigation.
Caries Detection on Intraoral Images Using Artificial Intelligence
Authors: Kühnisch J. , Meyer O. , Hesenius M. , Hickel R. , Gruhn V.
Published: August 2021

Although visual examination (VE) is the preferred method for caries detection, the analysis of intraoral digital photographs in machine-readable form can be considered equivalent to VE. While photographic images are rarely used in clinical practice for diagnostic purposes, they are the fundamental requirement for automated image analysis when using artificial intelligence (AI) methods. Considering that AI has not been used for automatic caries detection on intraoral images so far, this diagnostic study aimed to develop a deep learning approach with convolutional neural networks (CNNs) for caries detection and categorization (test method) and to compare the diagnostic performance with respect to expert standards. The study material consisted of 2,417 anonymized photographs from permanent teeth with 1,317 occlusal and 1,100 smooth surfaces. All the images were evaluated into the following categories: caries free, noncavitated caries lesion, or caries-related cavitation. Each expert diagnosis served as a reference standard for cyclic training and repeated evaluation of the AI methods. The CNN was trained using image augmentation and transfer learning. Before training, the entire image set was divided into a training and test set. Validation was conducted by selecting 25%, 50%, 75%, and 100% of the available images from the training set. The statistical analysis included calculations of the sensitivity (SE), specificity (SP), and area under the receiver operating characteristic (ROC) curve (AUC). The CNN was able to correctly detect caries in 92.5% of cases when all test images were considered (SE, 89.6; SP, 94.3; AUC, 0.964). If the threshold of caries-related cavitation was chosen, 93.3% of all tooth surfaces were correctly classified (SE, 95.7; SP, 81.5; AUC, 0.955). It can be concluded that it was possible to achieve more than 90% agreement in caries detection using the AI method with standardized, single-tooth photographs. Nevertheless, the current approach needs further improvement.
Tissue scale agent-based simulation of premalignant progressions in Barrett’s esophagus
Authors: Ozmen Ozgur , Nutaro James , Ostvar Sassan , Hur Chin , Kong Chung Yin
Published: August 2021

Barrett’s esophagus (BE) is a benign condition of the distal esophagus that initiates a multistage pathway to esophageal adenocarcinoma (EAC). Short of frequent intrusive (and costly) surveillance, effective screening for neoplasia in BE populations is yet to be established since progressors are rare and virtually undetectable without routine biopsies, which often sample only a small portion of the BE tissue. As a result, reliable estimation of the true prevalence of dysplasia in a BE population and evidence-based optimization of screening for at-risk individuals is challenging. Data-driven microsimulations, i.e., model-generated instances of disease history in a predefined virtual population, have found utility in the EAC screening literature as low-overhead alternatives to real-world hypothesis testing of optimal interventions for dysplasia. Despite the successes, computational limitations, paucity of knowledge and data on Barrett’s dysplasia, and the complexities of disease progression as a multiscale multiphysics process have hindered the treatment of disease progression in BE as a spatial process. Agent-based modeling of nucleation and proliferation processes in dysplasia warrants exploration in this context as an approximation that operates at a trade-off between computational tractability and precise representation of the composition and physics of the substrate (tissue). In this study, we describe spatially resolved simulations of premalignant progression toward EAC in a coarse-grained model of Barrett’s tissue that resolves the metaplastic tissue at a length scale of 0.42 mm (~3300 crypts/mm2). The model is calibrated to reproduce historical high-grade dysplasia prevalence when model-generated patients are screened using the Seattle protocol.
Uncanny Europe and Protective Europeanness: When European Identity Becomes a Queerly Viable Option
Authors: Szulc Łukasz
Published: August 2021

Europe has recently become closely associated with LGBTQ rights. It remains unclear, however, what is the role of this association in everyday European imaginations and identifications. Empirical research on European identity hardly ever discusses the role of LGBTQ rights. Nor do we know much about European identifications of LGBTQ people themselves. In this article, I address those gaps from the perspective of Polish LGBTQs in the UK. Drawing on 30 interviews from a recent two-year research project, I discuss my participants’ European imaginations and identifications by developing the concepts of ‘uncanny Europe’ and ‘protective Europeanness’. I show how my participants tend to view Europe as ‘diverse’, ‘open’ and ‘tolerant’, while attributing those characteristics exclusively to Western Europe. I also demonstrate that they tend to readily identify as European in the context of increasingly hostile national identities, with the increasing anti-Polish xenophobia in the UK and growing anti-LGBTQ discrimination in Poland.
On the recursive relationship between gentrification and labour market precarisation: Evidence from two neighbourhoods in Athens, Greece
Authors: Gourzis Konstantinos , Herod Andrew , Chorianopoulos Ioannis , Gialis Stelios
Published: August 2021

Gentrification and labour precarisation constitute prominent responses to urban capitalist crises. They have typically been addressed in the literature as distinct processes. Even though they can indeed occur independently of one another, here we argue that they are also often deeply interconnected. To do so, we utilise a mix of fieldwork and secondary data to investigate how gentrification has both fostered labour precarisation but also how it has been supported by it, within a context of economic recession yet growing tourist inflows into two neighbourhoods (Koukaki and Kerameikos) in central Athens, Greece. Our findings show that the growth of precarious labour in construction has facilitated the development of several gentrification loci whilst, in turn, gentrification’s consolidation has encouraged the growth of poor working conditions in local lodging, hospitality/catering, and creative activities. Ultimately, in highlighting the role of labour precarisation in gentrification, the paper argues that these processes are more than mere parts of an opportunistic conjuncture. Instead, their interconnectedness constitutes an integral part of the city’s contemporary urbanisation, being a continuation of the crisis-struck, construction-driven economic models that have historically characterised much of the Mediterranean European Union.
Natural population growth and urban management in metropolitan regions: Insights from pre-crisis and post-crisis Athens, Greece
Authors: Vinci Sabato , Egidi Gianluca , Salvia Rosanna , Gimenez Morera Antonio , Salvati Luca
Published: August 2021

Between the 1970s and the 1990s, cities in Southern Europe experienced a progressive delocalisation of population, settlements and activities over larger regions. Economic downturns have increasingly influenced more recent waves of metropolitan growth, shaping differentiated patterns of urban change. While some cities evolved towards accelerated population dynamics in central districts responding to re-urbanisation impulses, other agglomerations were intrinsically bounded in a sort of ‘late suburbanisation’, with demographic shrinkage of both inner districts and rural areas, and uneven expansion of suburban population. By providing a comprehensive interpretation of the socioeconomic mechanisms underlying recent urban expansion, this study illustrates a diachronic analysis of population dynamics over multiple spatial scales and time frames in a metropolitan region of Southern Europe (Athens, Greece) between 1999 and 2019. Natural population balance was investigated vis à vis selected territorial indicators using descriptive, inferential and multivariate statistics. Results of the analysis identify different social forces underlying suburban population growth during economic expansion (2000s) and recession (2010s), evidencing a distinctive response of local communities to economic downturns that depends mostly on the background context (affluent versus disadvantaged neighbourhoods). Given the multiplicity of territorial dimensions involved in urban growth, our findings highlight how economic downturns distinctively shape metropolitan development based on locally differentiated demographic dynamics.
Successful treatment of multiple relapsed–refractory Langerhans cell histiocytosis with cyclosporine
Authors: Özyörük Derya , Yozgat Ayça Koca , Kaçar Dilek , Yazal Erdem Arzu , Işık Melek , Güzelküçük Zeliha , Hacısalihoğlu Şadan
Published: August 2021

Langerhans cell histiocytosis is a rare hematologic disorder and patients who fail first-line treatment have a poor prognosis, and require more intensive treatment. We present an infant diagnosed with multisystem Langerhans cell histiocytosis refractory to multimodal therapy who was successfully treated with cyclosporine. Cyclosporine might be an effective alternative drug as nonmyelosuppressive rescue therapy for multiple relapsed-refractory Langerhans cell histiocytosis that has not achieved remission with cladribine and cytarabine therapy.
Cemiplimab- and nivolumab-induced myasthenia gravis: two clinical cases
Authors: Canino Fabio , Pugliese Giuseppe , Baldessari Cinzia , Greco Stefano , Depenni Roberta , Dominici Massimo
Published: August 2021

Immune-related myasthenia gravis is a rare, disabling, and potentially fatal adverse event of immune checkpoint inhibitor treatment. It is important to identify and manage it promptly. We present two cases of immune-related de novo myasthenia gravis observed at the Modena Cancer Center in two elderly patients treated with two anti-PD-1 monoclonal antibodies: cemiplimab and nivolumab.
Unusual presentation of extranodal diffuse large B-cell lymphoma in a solid-organ recipient during long-term immunosuppressive treatment
Authors: Camerini Chiara , Sant’Antonio Emanuela , Ginori Alessandro , Pellegri Marco , De Gaudio Cataldo , Banti Elena , Ciliberti Vincenzo , Parrini Manuela , Bozzoli Laura , Simonetti Federico , Capochiani Enrico
Published: August 2021

Introduction:

Posttransplant lymphoproliferative disorders (PTLDs) refer to a group of diseases, including diffuse large B-cell lymphoma (DLBCL), that develop after solid organ transplantation or hematopoietic stem cell transplantation. Extranodal involvement in PTLDs is common. Reports about exclusive bone marrow involvement are rare.

Case description:

A 70-year-old woman, who had undergone kidney transplantation in 2018, was diagnosed with exclusively extranodal, Epstein-Barr virus–negative DLBCL, with bone marrow and spleen involvement, during long-term immunosuppression. She achieved complete remission with combined immunochemotherapy and temporary hold of immunosuppression.

Conclusions:

This case shows an uncommon clinical presentation of DLBCL, which was challenging to diagnose, being entirely extranodal. The favorable clinical course relied on timely diagnosis and a multidisciplinary approach. Long-term consequences of posttransplant immunosuppression require a high level of suspicion for an appropriate management, aimed at preserving the graft while eradicating the lymphoproliferative disorder.
Evaluating the Sustainability of Urban Food Recovery Programs: A Quantitative Assessment in Chicago
Authors: Zheng Junjun , Ai Ning
Published: August 2021

This study demonstrates the critical need for strategic transportation planning for sustainable food waste management in urban regions. The majority of food waste is generated from non-industrial sectors (i.e., residential, commercial, and institutional sectors that cluster in cities), while over two-thirds of discarded food could have been edible. Food recovery programs (FRPs) can help reduce food wastage, avoid the negative impacts of landfill disposal, and mitigate food insecurities. Notably, FRPs shift long-haul waste transport services destined for a central landfill location to local, short, and time-sensitive pick-up and delivery trips, which have not been carefully studied. This study quantifies the economic efficiency (i.e., cost) and environmental impact (i.e., emissions) of urban FRP scenarios by incorporating the characteristics of surplus food pick-up options, fleet, urban built environment, and donor program participation rates. The results of an empirical study in Chicago, U.S., show that urban FRPs can be both economically efficient and environmentally beneficial, although the preferred strategy for FRPs may vary by neighborhood characteristics. With strategic planning and management, the transportation cost could be as low as $ 0.06/lb of recovered food. Meanwhile, diverting 1 ton of edible food from landfills, on average, reduces greenhouse gas emissions by 97%, or 0.51 MTCO2e. If the estimated volume of 10,000 tons of surplus food in Chicago can be fully recovered, the regional net emission reduction can reach 5,100 MTCO2e, which is equivalent to removing 1,110 vehicles from the roads. This study is anticipated to provide planning insights into initiating and scaling up city-wide FRPs.
Who Are Gun Owners in the United States? A Latent Class Analysis of the 2019 National Lawful Use of Guns Survey
Authors: Boine Claire , Caffrey Kevin , Siegel Michael
Published: August 2021

We used data from the 2019 National Lawful Use of Guns Survey to segment the gun-owning population into different subcultural categories. Performing a latent class analysis, we introduce six types of indicators: (1) the types of firearm owned, (2) the reported primary reason for owning a firearm, (3) involvement in various gun-related activities, (4) Second Amendment activism, (5) the extent to which those in one’s social network own guns, and (6) measures of symbolic meanings attached to firearms. We introduce gender, race, U.S. region, and political affiliation as covariates. We find six classes of gun owners. The largest group (28 percent) is composed of family protectors who go to the shooting range and feel empowered by their guns. The second largest category (19 percent) is made up of incidental gun owners motivated by protection or family tradition. The third group (18 percent) consists of Second Amendment activists who engage in multiple gun-related activities and are resistant to social change. The fourth category (13 percent) contains target shooters. The fifth group (12 percent) is made up of hunters. The sixth category (11 percent), self-protectors, has a majority of women (51 percent). Our findings add to a very recent body of literature on variations in the meanings that guns have for people. In particular, we demonstrate that there are stark cultural differences between gun owners and that the body of existing research on this topic has mostly focused on the Second Amendment activists, who only represent about 18 percent of all gun owners.
More Than Words: Anxiety, Self-Esteem, and Behavioral Problems in Children and Adolescents With Dyslexia
Authors: Zuppardo Linda , Serrano Francisca , Pirrone Concetta , Rodriguez-Fuentes Antonio
Published: August 2021

This study focused on psycho-affective and behavioral problems in children and adolescents with dyslexia. It aims to define clinical psycho-affective and behavioral profiles of dyslexia beyond those found in existing descriptions of the cognitive, neural, and behavioral correlates. The study focused specifically on the understudied population of native Italian-speaking students. Characteristics of anxiety and self-esteem, as psycho-affective factors, and a variety of associated behavioral problems were studied in a sample of children and adolescents with dyslexia ( n = 22) and compared to those of a group without learning disabilities ( n = 25). The findings suggest the group of participants diagnosed with dyslexia exhibited psycho-affective symptoms, especially anxiety and low self-esteem in social and academic situations more frequently than the control group. These problems were related to reading measures. More research is needed to determine how they are related and their interaction. Overall, these findings are useful in clarifying the profile of psycho-affective symptoms in the development of academic difficulties in children and adolescents with dyslexia. In some cases, school personnel focus their interventions only on the academic difficulties and not the psycho-affective or behavioral problems. These findings could have implications regarding intervention for this population.
Retirement? Other Ways Out of the Labour Market Are Far More Worrying for Health: Results from a Matching Approach Study
Authors: Pirani Elena , De Santis Gustavo , Zanasi Francesca
Published: August 2021

Objective

Despite a growing body of research, the effects of retirement on health are not clear. The study explores the role played by the path out of the labour market (formal retirement vs. unemployment or family reasons), accounting for individual heterogeneity. Methods: Propensity score matching approach is employed on longitudinal data from the Survey of Health, Ageing and Retirement in Europe (2004–2015). Results: While health does not change significantly for those who formally retire, it worsens considerably for those who leave the labour market for other reasons. Moreover, health outcomes turn out to be highly heterogeneous, depending on individual socio-economic and job-related characteristics. Discussion: Leaving the labour market in one’s mature years is a complex transition. Future research should focus on understanding and combating the causes of premature exit from the labour market, a relevant concern both in economic terms and on health grounds, in the light of our results.
Overcoming theoretical stagnation through cultural–historical neuropsychology: The case of dyslexia
Authors: Solovieva Yulia , Koutsoklenis Athanasios , Quintanar Luis
Published: August 2021

In this article we argue that cultural–historical neuropsychology manages to escape the theoretical stagnation that characterises the field of dyslexia. To support our argumentation, we first define cultural–historical psychology and neuropsychology and determine their subject matter. Afterwards, we provide an outline of how reading and reading difficulties are perceived through the prism of cultural–historical neuropsychology. We then discuss several mainstream conceptualisations of dyslexia that contribute to the theoretical stagnation in the field. Finally, we explain how cultural–historical neuropsychology avoids each theoretical barrier imposed by mainstream conceptualisations.
Long non-coding RNA LINC00630 facilitates hepatocellular carcinoma progression through recruiting transcription factor E2F1 to up-regulate cyclin-dependent kinase 2 expression
Authors: Kang Jian , Huang Xu , Dong Weiguo , Zhu Xueying , Li Ming , Cui Ning
Published: August 2021

This study is aimed to investigate the role of long non-coding RNA 630 (LINC00630) in hepatocellular carcinoma (HCC). Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to examine LINC00630 expression in HCC cell lines and tissues. After LINC00630 was overexpressed or depleted in HCC cell lines, cell counting kit-8 (CCK-8) assay, BrdU assay, and flow cytometry were conducted for detecting HCC cell multiplication, apoptosis, and cell cycle progression. The catRAPID database was adopted to predict the binding relationship between LINC00630 and E2F transcription factor 1 (E2F1), and RNA pull-down and RNA immunoprecipitation (RIP) assays were carried out to verify this binding relationship. The binding of E2F1 to the cyclin-dependent kinase 2 (CDK2) promoter region was verified by dual-luciferase reporter gene assay and chromatin immunoprecipitation-quantitative polymerase chain reaction (ChIP-qPCR) assay. Western blotting was conducted to detect the protein expression of E2F1 and CDK2 in HCC cells. We report that LINC00630 expression was up-regulated in HCC and was significantly correlated with TNM stage and lymph node metastasis. LINC00630 overexpression facilitated HCC cell proliferation and cell cycle progression and inhibited the cell apoptosis, while LINC00630 knockdown had the opposite effects. LINC00630 directly bounds with E2F1. LINC00630 overexpression enhanced the binding of E2F1 to the CDK2 promoter region, thereby promoting CDK2 transcription, whereas knocking down LINC00630 inhibited CDK2 transcription. Collectively, LINC00630 promoted CDK2 transcription by recruiting E2F1 to the promoter region of CDK2, thereby promoting the malignant progression of HCC. Our data suggest that LINC00630 is a promising molecular target for HCC.
Nationalisation of Health Workforce in Saudi Arabia’s Public and Private Sectors: A Review of Issues and Challenges
Authors: Albejaidi Fahad , Nair Kesavan Sreekantan
Published: August 2021

Presently, Saudi Arabia depends largely on expatriate health workforce for delivery of health services. This article provides an overview of Saudization policy introduced by the Kingdom of Saudi Arabia and analyses its underlying impact on health workforce in public and private sectors. It also examines key strategic initiatives undertaken by the government for health workforce development and challenges of replacing expatriates in the country as envisaged in the Vision 2030. There are concerns about low participation of females in nursing, mainly due to a poor image attached to the profession, and further exacerbated by religious and cultural factors. There is a strong need to adopt a health workforce development policy that integrates local culture, values and social ties. Government needs to follow a multipronged approach to change the mindset of citizens to take up health care jobs, particularly nursing and pharmacist professions.
Pre-Teen Gang Involvement Is Associated With Teenage Gambling Behavior: Exploratory Findings From a Longitudinal Cohort Study of Pacific Youth in New Zealand
Authors: Bellringer Maria E. , Pearson Janet , Iusitini Leon
Published: August 2021

Pacific youth in New Zealand have a disproportionately high risk for gambling and gang involvement compared with New Zealand European youth. Limited evidence indicates that youth gang involvement is associated with problem gambling; no research shows if it is associated with gambling. We conducted exploratory secondary analyses of data from 1063 Pacific youth and their mothers using data from two time points (age nine and 14 years) from a longitudinal cohort study. Gang involvement at age nine years was significantly associated with gambling at age 14 years, with adjusted odds of 2.25 (95% CI [1.16, 4.37]). Of confounders, having a mother with a partner and Cook Islands ethnicity appeared protective against gambling at age 14 years. Despite some study limitations, as youth gambling can lead to subsequent adult problem gambling, our findings highlight the importance of understanding why Pacific youth join gangs, to inform public health policies to reduce the potential for future development of harmful behaviors.
Hong Kong Poison Information Centre: Annual report 2019
Authors: Chow Tin Yat Anthony , Chan Chi Keung , Ng Sze Hong , Tse Man Li
Published: August 2021

Background:

The Hong Kong Poison Information Centre (HKPIC) provides consultation service to health care professionals and collect epidemiological data on poisoning in Hong Kong since 2005.

Objective:

To report and analyse the data of Hong Kong Poison Information Centre on poisoning in 2019.

Methods:

This was a retrospective review of all poisoning cases recorded in the Poison Information and Clinical Management System of Hong Kong Poison Information Centre in 2019.

Results:

A total of 4016 poisoned cases were analysed, which involved 1698 men (42.3%), 2312 women (57.6%) and 6 sex‐unspecified patients (0.1%). Majority of cases (77.3%) were between 13 and 69 years of age, and 10.5% were teenagers 13–19 years of age. Self‐harm/suicidal attempt (42.1%), unintentional exposure (18.1%) and abusive substance use (11.1%) were common reasons of poisoning. Excluding ethanol, which was the common co‐ingestant, the five most common types of poison were benzodiazepines, paracetamol, household products, zopiclone and Chinese herbal medicine. While most patients were managed with supportive treatment, 16.5% and 16.8% of the consultation cases were treated with decontamination and antidotes, respectively. Majority of cases recovered uneventfully, but 1.0% died and 4.7% had a major outcome. A total of six interesting cases and two outbreaks were discussed in this report.

Conclusion:

This 14th annual report provided updated epidemiological information on the pattern of poisoning in Hong Kong and highlighted a number of important changes compared with our previous reports.