bluuebunny/crossref_metadata_2025 huggingface dataset:
Artificial Intelligence and Cheminformatics-Guided Modern Privileged Scaffold Research
Authors: Qiu Han-Yue , Clausen Rasmus Praetorius , He Yun , Zhu Hai-Liang
Published: May 2021

With the rapid development of computer science in scopes of theory, software, and hardware,
artificial intelligence (mainly in form of machine learning and more complex deep learning)
combined with advanced cheminformatics is playing an increasingly important role in drug discovery
process. This development has also facilitated privileged scaffold-related research. By definition,
a privileged scaffold is a structure that frequently occurs in diverse bioactive molecules, either
has a diverse family affinity or is selective to multiple family members in a superfamily, whilst it is
different from the“frequent hitters”, or the “pan-assay interference compounds”. The long history
of the use of this concept has witnessed a functional shift from stand-alone technology towards an
integrated component in the drug discovery toolbox. Meanwhile, continuous efforts have been dedicated
to deepening the understandings of the features of known privileged scaffolds. In this contribution,
we focus on the current privileged scaffold-related research driven by state-of-art artificial
intelligence approaches and cheminformatics. Representative cases with an emphasis on distinct research
aspects are presented, including an update of the knowledge on privileged scaffolds, proofof-
concept tools, and workflows to identify privileged scaffolds and to carry on de novo design, informatic
SAR models with diversely complex data sets to provide an instructive prediction on new
potential molecules bearing privileged scaffolds.
Synthesis of Novel Amide and Schiff’s Base Functionalized Novel Pyrido[ 1,2-a] Pyrimidin-4-One Derivatives and Their Anticancer Activity Studies
Authors: Abba Chiranjeevi , Betala Sailu , Racha Hanumandlu
Published: May 2021

A series of novel amide and Schiffs base functionalized novel pyrido[1,2-a] pyrimidin- 4-one derivatives was prepared starting from 6-(thiophen-2-yl)/phenyl-4-(trifluoromethyl) pyridin- 2-amine 1a and 1b. These compounds on reacting with EMME afford compounds 2a and 2b, followed by cyclization to afford compounds 3a and 3b. Treatment of compounds 3a and 3b with hydrazine hydrate gave compounds 4a and 4b, which further reacted with different substituted aromatic aldehydes to give Schiff’s base derivatives 5a-j. In another way, compounds 3a, 3b by reacting with aliphatic amines give amide derivatives 6a-f. All the compounds, 5a-j and 6a-f, were screened against four human cancer cell lines (HeLa, COLO205, Hep G2, and MCF 7). Among all the derivatives, compounds 5c, 5e, 6a, and 6b showed promising anticancer activity.
Conocimientos sobre bioética, ética e integridad científica de la investigación en programas de medicina y odontología, Cartagena – Colombia
Authors: Cáceres Matta Sandra Viviana , García Alarcón Rodrigo Hernán
Published: May 2021

Ante la necesidad de unificar conceptos, Colciencias en trabajo colaborativo con los nodos regionales de ética, bioética e integridad científica en el año 2018, inició el proyecto diagnóstico sobre conocimientos en esta área, debido a que se evidenció que aún no se tenía claro cuáles son las premisas desde integridad científica, que deben contemplar disciplinas como medicina y odontología, en la región Caribe, para diseñar e implementar proyectos de investigación específicamente en los trabajos de investigación formativa como requisito de grado. En tal sentido, el objetivo de la presente indagación fue identificar los conocimientos que poseen los estudiantes de medicina y odontología de la Facultad de Ciencias de la Salud en la Universidad del Sinú – Seccional Cartagena, con respecto a ética, bioética e integridad científica de la investigación. Desde el punto de vista metodológico el estudio es de tipo empírico–analítico, con un enfoque cuantitativo. Se encuestó a una población de 50 estudiantes de los programas de medicina y odontología de pregrado. Los resultados destacan lo siguiente: la categoría de bioética en investigación científica, obtuvo el mayor porcentaje de respuestas correctas; los estudiantes de medicina, lograron el mayor porcentaje de respuestas acertadas; el desempeño de las participantes del sexo femenino fue mejor. En base a los hallazgos se concluye que las sociedades actuales exigen profesionales de la salud conocedores de su disciplina, que desarrollen investigaciones con calidad humana, excelencia ética, bioética e integridad científica en la investigación al igual que pensamiento crítico.
La política pública como eje del desarrollo sostenible en las ciudades de América Latina y el Caribe: una visión humanística compartida por Colombia
Authors: Acurero Luzardo Marilú , Gómez Martínez Efraín , Granados-Suarez Lady Mileth , Arce Nader Jaime
Published: May 2021

El desarrollo sostenible es un camino seguro y viable para: la reducción de la pobreza extrema, garantizar la educación, lograr la inclusión social, el incremento de la productividad de las regiones y las empresas, mejorar las cifras del empleo formal, asegurando la satisfacción de las necesidades básicas. Desde este panorama se examina la política pública como eje articulador del desarrollo sostenible en América Latina, haciendo énfasis en la visión humanística de Colombia; en este sentido, el presente estudio de carácter documental, analiza las posturas teóricas de autores como Brundtland (1987); Jordán (2015); Winchester (2006)nacionales, subnacionales y locales. Requiere la convergencia en el espacio urbano de la necesidad de internalizar los costos ambientales (vía mejoras en la gestión y gobernabilidad de los sistemas asociados, entre otros, quienes consideran que el desarrollo económico sostenible de las naciones, articulado con las políticas públicas generadas a partir de los acuerdos internacionales suscritos por las naciones y gobiernos, al acoplarse con los sectores económico, social y ambiental, impactan la región. Del análisis se desprende que esta articulación configuraría territorios sustentables, con sociedades más equitativas y economías competitivas, pues se aumentan los niveles de producción, disminuyen los índices de pobreza extrema, se fortalece la educación, el empleo se reactiva, la competitividad e innovación en los territorios tiende a incrementarse; no obstante, se requirieren los esfuerzos conjuntos de una sociedad civil organizada, capaz de priorizar los diferentes problemas que le afectan bajo un contexto de justicia y paz, a fin de cerrar las brechas existentes en los diferentes estratos de la población, disminuir el margen diferencial, promoviendo la inclusión y el desarrollo humano de las personas.
The Elephant in the Room and Straw Men on Fire
Authors: Faraday Fay
Published: May 2021

A great unacknowledged challenge in litigating systemic discrimination claims under the section 15 equality guarantee of the Canadian Charter of Rights and Freedoms1 is that claimants bear a double burden. Like all litigants, they must meet the burden of proving the elements of their legal claim. But, before they can do that, equality claimants must often first meet the extraordinary burden of dislodging judges’ phenomenological anchoring in worldviews shaped by privilege. Where judges lack lived experience of systemic oppression, claimants must convince them that oppression exists. This gulf between lived experiences — what I call the reality gap — is the elephant in the room in many section 15 cases.

1 s 15, Part I of the Constitution Act, 1982, being Schedule B to the Canada Act 1982 (UK), 1982, c 11.
Fatty Acid Composition of Meat Animals as Flavor Precursors
Authors: Dinh Thu T. N. , To K. Virellia , Schilling M. Wes
Published: May 2021

This article provides an overview of fatty acids in meat, their variation among animal species, and the roles of fatty acids as flavor precursors. Animal fat mostly consists of triglycerides and phospholipids. Fats from ruminant (cattle, sheep, and goats) and monogastric (pigs and horses) animals have similar fatty acids with more saturated fatty acids and monounsaturated fatty acids than polyunsaturated fatty acids. In monogastric animals, fatty acids in the muscle reflect the composition of diets, whereas ruminant fatty acids are more saturated because of biohydrogenation in the rumen. Lipid- derived flavor compounds are formed from the thermal oxidation of fatty acids during cooking, producing more desirable aromatic compounds than autoxidation. Monounsaturated fatty acids such as oleic acid and polyunsaturated fatty acids such as linoleic acid in meat produce various volatile compounds contributing to cooked meat aromas. Under most cooking conditions, lipid-derived flavor compounds are usually predominant. However, these compounds have greater thresholds than those derived from water-soluble compounds, such as the Maillard reaction products. The interactions between lipid oxidation products and Maillard compounds are more important for the development of meat flavor than originally thought. Moreover, fat-derived volatile compounds provide flavor notes indicative of species identification.
ЦИФРОВАЯ ТРАНСФОРМАЦИЯ СБОРОЧНО-­МОНТАЖНОГО ПРОИЗВОДСТВА, ИЛИ КАК ДОСТИЧЬ KPI ПО ЦИФРОВИЗАЦИИ
Authors: Чернов Д.
Published: May 2021

Рассмотрены решения для цифровой трансформации сборочно-­монтажного производства, предлагаемые ООО «Остек-­СМТ». Отмечено, что комплекс решений Остек-­СМТ полностью адаптирован под отечественные условия и позволяет обеспечить эффективность мирового уровня.
Weakly convex hypersurfaces of pseudo-Euclidean spaces satisfying the condition LkHk+1 = λHk+1
Authors: Pashaie Firooz
Published: May 2021

In this paper, we try to give a classification of spacelike hypersurfaces of the Lorentz-Minkowski space-time E1n+1, whose mean curvature vector field of order (k+ 1) is an eigenvector of the kth linearized operator Lk, for a non-negative integer k less than n. The operator Lk is defined as the linear part of the first variation of the (k + 1)th mean curvature of a hypersurface arising from its normal variations. We show that any spacelike hypersurface of E1n+1 satisfying the condition LkHk+1 = λHk+1 (where 0 ≤ k ≤ n − 1) belongs to the class of Lk-biharmonic, Lk-1-type or Lk-null-2-type hypersurface. Furthermore, we study the above condition on a well-known family of spacelike hypersurfaces of Lorentz-Minkowski spaces, named the weakly convex hypersurfaces (i.e. on which all of principle curvatures are nonnegative). We prove that, on any weakly convex spacelike hypersurface satisfying the above condition for an integer k (where, 0 ≤ r ≤ n−1), the (k + 1)th mean curvature will be constant. As an interesting result, any weakly convex spacelike hypersurfaces, having assumed to be Lk-biharmonic, has to be k-maximal.
La transición de Trump a Biden en Estados Unidos: implicaciones para la relación México – Estados Unidos. Un análisis desde un enfoque nacional y subnacional
Authors: Zepeda Roberto
Published: May 2021

El ascenso del demócrata Joseph Biden a la presidencia de Estados Unidos en 2021 representa el inicio de una nueva era con múltiples implicaciones que es pertinente analizar. Este articulo examina los cambios en el enfoque de política doméstica y exterior de Estados Unidos, en la transición de Trump a Biden. Asimismo, se analizan las perspectivas de la relación de EE.UU. con México, desde un plano nacional y subnacional, en la era Biden. El argumento principal es que la administración de Joe Biden marca un cambio notable respecto a la administración Trump. Entre los cambios notables, se encuentran la estrategia del gobierno federal para hacerle frente a los efectos de la pandemia Covid-19; mientras que se percibe un giro notable en temas de política exterior como migración, medio ambiente y seguridad, lo cual traerá mayores ventajas que desventajas para México.
Paleomagnetic estimation of emplacement temperature of pyroclastic deposits-preliminary study of caldera de los Humeros and Alchichica crater
Authors: Urrutia Fucugauchi Jaime
Published: May 2021

Se reportan resultados paleomagnéticos de un estudio preliminar de depósitos piroclásticos de la caldera de Los Humeros y del cráter Alchichica. Los datos son analizados siguiendo un criterio simple de clasificaci6n que usa los resultados iniciales del magnetismo remanente y los obtenidos por desmagnetizaci6n. Los dep6sitos estudiados en el cráter de explosi6n de Alchichica fueron depositados con temperaturas de emplazamiento de 100°C a 300°C. El dep6sito estudiado en la caldera de Los Humeros se emplaz6 a una temperatura mayor, de aproximadamente 4S0°C o mayor.
Calculating semantic relatedness of lists of nouns using WordNet path length
Authors: Ganbold Amarsanaa , Batsuren Khuyagbaatar
Published: May 2021

Lists of semantically related words are better recalled on immediate memory tests than otherwise equivalent lists of unrelated words. However, measuring the degree of relatedness is not straightforward. We report three experiments that assess the ability of various measures of semantic relatedness—including latent semantic analysis (LSA), GloVe, fastText, and a number of measures based on WordNet—to predict whether two lists of words will be differentially recalled. In Experiment 1, all measures except LSA correctly predicted the observed better recall of the related than the unrelated list. In Experiment 2, all measures except JCN predicted that abstract words would be recalled equally as well as concrete words because of their enhanced semantic relatedness. In Experiment 3, LSA, GLoVe, and fastText predicted an enhanced concreteness effect because the concrete words were more related; three WordNet measures predicted a small concreteness effect because the abstract and concrete words did not differ in semantic relatedness; and three other WordNet measures predicted no concreteness effect because the abstract words were more related than the concrete words. A small concreteness effect was observed. Over the three experiments, only two measures, both based on simple WordNet path length, predicted all three results. We suggest that the results are not unexpected because semantic processing in episodic memory experiments differs from that in reading, similarity judgment, and analogy tasks which are the most common way of assessing such measures.
Anti-Diabetic and Antioxidant Effects of Methanolic Flower Head Extract of Tagetes Patula in Streptozotocin and Dexamethasone Induced Diabetic Rats
Authors: M. Ganga Raju  , Gayathri S  , N V L Suvarchala Reddy V  , Anusha K  , Pavani K
Published: May 2021

Diabetes is a chronic metabolic disorder characterized by a high blood glucose concentration, i.e., hyperglycemia or caused by insulin deficiency, often combined with insulin resistance. In the Present study, the antidiabetic and antioxidant activity of the methanolic extract of Tagetes patula flower heads was screened out in rodent models. The pharmacological evaluation was carried out using 200 and 400 mg/kg, b.w. The in-vivo antidiabetic activity was performed in streptozotocin, dexamethasone- induced diabetic models and oral glucose tolerance test. Metformin hydrochloride was used as a standard. The parameters like blood glucose levels, insulin levels, homeostasis assessment of insulin resistance, insulin sensitivity, and fasting glucose-insulin ratio were estimated in these models. The in-vitro antioxidant activity of methanolic extract of Tagetes patula was performed by using hydroxyl radical scavenging assay and Ascorbic acid was used as a standard. The preliminary phytochemical screening of Tagetes patula revealed  the   presence  of  phytoconstituents  like   alkaloids,  flavonoids,  saponins,  steroids,  phenols,  carbohydrates, triterpenoids, and tannins. The extract showed a significant decrease in the elevated blood glucose levels in streptozotocin, dexamethasone-induced diabetic models, and also in the oral glucose tolerance test. The extract prevented insulin resistance and significantly  increased  insulin  sensitivity  in  the  dexamethasone-induced  model.  The  various  phytochemical  constituents  like alkaloids, flavonoids, saponins, steroids, and phenols might be responsible for lowering the blood glucose levels in the animal models  mentioned  above.  The  extract showed significant  scavenging  activity  against  hydroxyl  free  radicals.  From  the  above outcomes, it is flawless that the methanolic extract of Tagetes patula has antidiabetic and antioxidant activities.
AN ANALYSIS OF ILLOCUTIONARY AND PERLOCUTIONARY SPEECH ACTS OF AN INSTAGRAM ONLINE SHOPPING ACCOUNT
Authors: Dewi Cahya Wati
Published: May 2021

Language is important in human’s life because we cannot communicate with one another without it. Therefore, it is appealing to study speech acts since we can understand how utterances are reflected in actions. It is also interesting to analyze the speech acts used in Instagram captions. This study aims to analyze speech acts of an online shopping account on Instagram that is an international brand N.Y.X. Illocutionary speech acts aims to state something to influence the listener to do activities according to what the speaker means. Based on the data obtained, the illocutionary act of the online shopping account @nyxcosmetics is in the form of directive and expressive acts. The directives illocution acts are ordering and demanding. On the other hand, the perlocutionary aims to portray the act of offering someone. Keywords: Speech acts, Illocutionary acts, Perlocutionary acts
ANALYSIS OF STUDENTS’ AND TEACHERS’ RESPONSE OF THE IMPLEMENTATION OF SCIENTIFIC APPROACH WITH PODCAST APP IN TEACHING LISTENING
Authors: Kurnanika Desyari Lestari , Rachmijati Cynantia
Published: May 2021

This research is aimed to analyze teachers and students respond in teaching listening skills to the Tenth Grade Students using a scientific approach with learning English podcast applications. This research uses qualitative descriptive, this research is purposed to collect the data both qualitative and quantitative approaches. questionnaires and Interviews. it was done in tenth-grade consist of 21 students in senior high school. The result shows that from two indicators are attention and relevance, from these indicators show that, most of the students respond stated agree in the indicators attention with percentage 471.4% with the number of frequencies 99 and for indicators relevance, most students stated neutral with percentage 228.6% with total frequency 48. Also, teacher responses show that students are quite enthusiastic and it is quite an effective way to teach listening. From this research, it can conclude most of the students choose to agree, that the use of podcast make students have a high motivation to the learn, improve retention, easy to understand the material, avoid the wrong concept, it is not boring, and improve listening comprehension, additionally teacher agree that podcast can make students quite enthusiastic during the learning activity. must include an abstract of 200 words or fewer. Keywords:  Listening skill, podcast, respond, Motivation
STUDENTS’ RESPONSES TOWARD THE IMPLEMENTATION OF BINGO GAME WITH SCIENTIFIC APPROACH IN TEACHING WRITING DESCRIPTIVE TEXT
Authors: Putri Febriani Sahna , Kareviati Evie
Published: May 2021

This study aimed to investigate the implementation of the Bingo game technique in teaching writing and to find out the students’ participation toward the implementation of the Bingo game. The research instruments used interview and observation sheet. This study was conducted at Junior High School in Cimahi. The students of VII F class were selected as the participant of the research. The research used descriptive qualitative method. The data was obtained from classroom observation and students’ interview. The result showed that Bingo game can be used  to motivate students in writing skill. It was very helpful in providing the students with more enjoyable activities which made the students involved in the teaching and learning process actively. Keywords:  Writing, Bingo Game, Descriptive Text.
IMPROVING STUDENTS’ WRITING SKILLS IN DESCRIPTIVE TEXT USING PICTURE WORD INDUCTIVE MODEL (PWIM) STRATEGY
Authors: Oktafiani Desy , Husnussalam Hendra
Published: May 2021

The objective of the study is to provide the students treatment and make the students easy in learning process of writing descriptive text, therefore to improve the students writing skills in English by using PWIM strategy. The participants are the 7th grade students of Junior High School at Cimahi in academic year 2019/2020 which consist of 32 students. The study using CAR with two cycles to observe the activities and responses of students in classroom. Result of the study could be seen from the improvement score from pretest to posttest 2 with a minimum score of 75 and maximum score of 85 in posttest 2. Keywords:  Writing, Descriptive Text, PWIM Strategy, CAR
Políticas Públicas na Educação do Campo: a Formação Docente no Município de Serra do Ramalho
Authors: Rolim Inaiara Alves , Moreira Edna Souza
Published: May 2021

A presente pesquisa intitulada ‘Políticas públicas na Educação: reflexões a partir do processo de formação dos docentes que atuam em escolas no campo no município de Serra do Ramalho- BA’ objetivou compreender como acontece a formação dos professores que atuam nas escolas do meio rural e como esta formação implica na prática pedagógica. A pesquisa foi desenvolvida com a direção, os professores de uma escola do campo da cidade de Serra do Ramalho e com a coordenadora geral de educação do município. Utilizou-se da abordagem embasada nos pressupostos qualitativos, a pesquisa foi de campo do tipo participante, e para produzir os dados essa investigação fez uso do questionário, entrevista semiestruturada, diário de campo e análise documental. A análise dos dados permitiu construir uma visão mais ampla a respeito dos significados atribuídos à educação do campo, à formação específica para atuar nessa modalidade de educação, bem como, a visão desses sujeitos a respeito do tipo de educação que é oferecida aos povos do campo. Os dados mostraram, também, a necessidade de ampliar as oportunidades de formação inicial e continuada específicas para os educadores do campo, com vistas a oportunizar a construção de habilidades que os instrumentalizem para desenvolver práticas que respeitem a cultura camponesa e contribuam para a construção da autonomia dos povos do campo.
Editorial
Authors: Dos Santos Arlete Ramos
Published: May 2021

Não se aplica.
From human settlement region to bird dominated grassland: Avian diversity in the Padampur grassland of Chitwan National Park, Nepal
Authors: Khadka Bed , Pathak Abhinaya , Wilson Jennifer , Paudel Prashamsa , Acharya Paras , Ram Ashok , Adhikari Lokendra
Published: May 2021

A Mosaics provide productive ecosystems that include foraging
opportunities, breeding grounds, and protection for birds, particularly
within mosaics of grassland, wetland, and savanna habitats. This study
explored the status of species diversity, richness, and seasonal
population rate of avian species within the mosaics of the Padampur
grassland of Chitwan National Park (CNP), Nepal. Point count surveys
were performed in 10 randomly selected plots by walking transects or
riding on elephant back during the rainy season. A total of 118 bird
species and 4905 individual birds belonging to 43 families was recorded.
Surveys and regression analysis revealed species preferred diverse
ecotone habitats interspersed with mosaics of tallgrass prairie, shrubby
grassland, savanna and marshy grassland. Regression models also revealed
occupancy rates were relatively consistent across seasons, however,
months within the rainy and the summer season were lower than autumn and
winter. Rarefaction curves showed sampling efforts of approximately 10
months to produce accurate estimates of species richness. Although the
diversity indices resulted in insignificant differences between the
plots, the CNP appears to provide preferred grassland habitat to bird
species all year round. This study suggests conservation efforts to
consider these survey methods and estimates when implementing
initiatives. This paper recommends concerned authorities to prioritize
and give continuity to bird conservation, including grassland management
alongside the wetlands within the CNP.
Genome size mediates the effect of environmental filtering in determining plant β-diversity across temperate grasslands
Authors: Zhang Hai-Yang , Lü Xiaotao , wei cunzheng , Powell Jeff , Wang Xiaobo , Xing Dingliang , Han Xing-Guo
Published: May 2021

Elucidating mechanisms underlying community assembly and biodiversity
patterns is central to ecology and evolution. Genome size (GS, i.e.
nuclear DNA content) determines species’ capacity to tolerate
environmental stress or to exploit new environments and therefore
potentially drive community assembly. However, its role in driving
β-diversity (i.e., the site-to-site variability in species composition)
remains unclear. We measured GS for 169 plant species and investigated
their occurrences within plant communities across 52 sites spanning a
3200-km transect in the temperate grasslands of China. We found
environmental factors showed larger effects on β-diversity of large-GS
than that of small-GS species. Community weighted mean GS increased with
mean annual precipitation, soil total nitrogen and phosphorus
concentrations, but decreased with mean annual temperature, suggesting a
negative selection against species with large GS in resources-limited or
warmer climates. These findings highlight the roles for GS in driving
community assembly and predicting species responses to climate change.
No Escape: The Influence of Substrate Sodium on Plant Growth and Tissue Sodium Responses
Authors: Santiago-Rosario Luis , Harms Kyle , Elderd Bret , Hart Pamela , Dassanayake Maheshi
Published: May 2021

As an essential micronutrient for many organisms, sodium plays an
important role in ecological and evolutionary dynamics. Although plants
mediate trophic fluxes of sodium, from substrates to higher trophic
levels, we know relatively little about plants’ comparative growth and
sodium accumulation responses to variation in substrate sodium. We
carried out a systematic review to examine how plants respond to
variation in substrate sodium concentrations. We compared growth and
tissue-sodium responses among 107 populations (67 species in 20 plant
families), broadly expanding beyond the agricultural and model taxa for
which several generalizations previously have been made. We hypothesized
a priori response models for each population’s growth and sodium
accumulation responses as a function of increasing substrate NaCl. We
used BIC to choose the best model. Additionally, using a phylogenetic
signal analysis, we tested for phylogenetic patterning of growth and
sodium accumulation responses across plant taxa. The influence of
substrate sodium on growth differed across taxa, with most populations
experiencing detrimental effects at high concentrations. Irrespective of
growth response, tissue concentrations of sodium for most taxa increased
as sodium concentrations in the substrate increased. We found no strong
associations between growth and types of sodium accumulation responses
across taxa. Our phylogenetic signal analyses found that evolutionary
history helps predict the distribution of total plant growth responses
across the phylogeny, but not sodium accumulation responses. Our study
suggests that saltier plants in saltier soils may prove to be a broadly
general pattern for sodium across plant taxa. Regardless of growth
responses, sodium accumulation mostly followed an increasing trend and
did not have any evident association with growth responses as substrate
sodium levels increased. Finally, plant adaptations to substrate sodium
vary with a degree of phylogenetic conservatism.
Delivery and neonatal outcomes in women with antepartum severe maternal morbidity: a population-based study.
Authors: Raineau Mégane , Deneux-Tharaux Catherine , Seco Aurélien , Bonnet Marie-Pierre
Published: May 2021

Objectives: To assess the incidence, causes, risk factors and adverse
outcomes of antepartum severe maternal morbidity (SMM) Design:
Population-based case–control study Setting: 119 Maternity hospitals, 6
French regions Population: All women with antepartum SMM (cases, N=601),
a randomly selected control sample of women who gave birth without SMM
in the same hospitals during the same period (controls, N=3650) Methods:
Uni- and multivariable logistic regression with multiple imputation Main
outcomes measure: Antepartum SMM, defined as a morbid event occurring
from 22 weeks of gestation and before the onset of labour Results:
Antepartum SMM complicated 0.33% of pregnancies (95%CI, 0.30-0.36).
Rates of prematurity, neonatal mortality, and transfer to the neonatal
intensive care unit were 10 times higher for babies whose mothers had
antepartum SMM than for the control mothers. Similarly, emergency
caesarean and general anaesthesia were more frequent in women with
antepartum SMM. Risk factors for antepartum SMM were maternal age
>35 (aOR 1.55; 95% CI, 1.22-1.97), increased body mass
index (aOR for 5kg/m2 increase, 1.24; 95% CI, 1.14-1.36), maternal
birth in sub-Saharan Africa (aOR, 1.80; 95% CI, 1.29-2.53),
pre-existing medical condition (aOR, 2.56; 95% CI, 1.99-3.30),
nulliparity (aOR, 2.26; 95% CI, 1.83-2.80), previous pregnancy-related
hypertensive disorders (aOR, 4.94; 95% CI, 3.36-7.26), multiple
pregnancy (aOR, 5.79; 95% CI, 3.75-7.26), irregular prenatal care (aOR,
1.86; 95% CI, 1.27-2.72). Conclusion: Antepartum SMM is rare but
associated with a massively higher incidence of adverse delivery and
neonatal outcomes.
Clinical and Echocardiographic Characteristics After Six Months of Sacubitril Valsartan in Chagas Heart Disease.
Authors: Figueiredo Clara , Melo Rodrigo de , Viana Taina , Jesus Aline Queiroz de , Silva Tainara da , Silva Vitor da , Carvalho William de , Silva Daniela da , Passos Luiz Carlos
Published: May 2021

Chagas cardiomyopathy is the most prevalent non-ischemic cardiomyopathy
in Latin America, with high morbidity and mortality even today.
Treatment of these patients is based on the use of medications for heart
failure. This study evaluated a cohort of patients with Chagas heart
disease who used sacubitril valsartan at a referral hospital for the
disease in Brazil. After six months, there was a symptomatic improvement
in these individuals assessed by the NYHA classification, with a 44.3%
reduction in the absolute number of patients classified as III-IV in the
period (p 0.035), but without changes in the parameters on the
echocardiogram for reverse ventricular remodeling and still high
mortality rate and hospitalization. These results emphasize the
importance of studying the use of sacubitril valsartan in chagas heart
disease to better describe its effectiveness taking into account the
peculiarities of these individuals.
CAREC Gender Assessment: Supplementary Document for the CAREC Gender Strategy 2030
Authors:   Asian Development Bank
Published: May 2021

Этот документ представляет собой диагностическую основу для анализа уровня гендерного равенства в странах Центральноазиатского регионального экономического сотрудничества (ЦАРЭС). Он также служит основой для разработки Гендерной стратегии ЦАРЭС до 2030 года и оценки эффективности Программы ЦАРЭС по включению гендерного фактора в ее операции. Анализ включает сравнение ключевых гендерных глобальных показателей, а также сквозных гендерных вопросов и вопросов человеческого развития – в особенности, таких как доступ женщин к достойной работе, экономическим возможностям, образованию и обучению, услугам здравоохранения, информационным и коммуникационным технологиям, а также инфраструктуре и государственным услугам, и участие женщин в принятии решений. Репрезентативная выборка из 107 проектов ЦАРЭС была проанализирована для выявления передовой практики, пробелов и упущенных возможностей в области учета гендерной проблематики.
The Use of Diuretic in Mechanically Ventilated Children with Viral Bronchiolitis: A Cohort Study
Authors: Agasthya Nisha , Chromey Kimberlee , Hertzog James H. , Chauhan Jigar C.
Published: May 2021

Introduction

Viral bronchiolitis is a leading cause of admissions to pediatric intensive care unit (PICU). A literature review indicates that there is limited information on fluid overload and the use of diuretics in mechanically ventilated children with viral bronchiolitis. This study was conducted to understand diuretic use concerning fluid overload in this population.

Material and methods

A retrospective cohort study performed at a quaternary children’s hospital. The study population consisted of mechanically ventilated children with bronchiolitis, with a confirmed viral diagnosis on polymerase chain reaction (PCR) testing. Children with co-morbidities were excluded. Data collected included demographics, fluid status, diuretic use, morbidity and outcomes. The data were compared between groups that received or did not receive diuretics.

Result

Of the 224 mechanically ventilated children with confirmed bronchiolitis, 179 (79%) received furosemide on Day 2 of invasive ventilation. Out of these, 72% of the patients received intermittent intravenous furosemide, whereas 28% received continuous infusion. It was used more commonly in patients who had a higher fluid overload. Initial fluid overload was associated with longer duration of mechanical ventilation (median days 6 vs 4, p<0.001) and length of stay (median days 10 vs 6, p<0.001) even with the use of furosemide. Superimposed bacterial pneumonia was seen in 60% of cases and was associated with a higher per cent fluid overload at 24 hours (9.1 vs 6.3, p = 0.003).

Conclusion

Diuretics are frequently used in mechanically ventilated children with bronchiolitis and fluid overload, with intermittent dosing of furosemide being the commonest treatment. There is a potential benefit of improved oxygenation in these children, though further research is needed to quantify this benefit and any potential harm. Due to potential harm with fluid overload, restrictive fluid strategies may have a potential benefit.
Optimalisasi Pembelajaran Seni Grafis bagi Guru Seni Budaya se-Kawedanan Jatinom, Klaten, Jawa Tengah
Authors: Nurjanah Devy Ika , Afandi Nizar Mohamad
Published: May 2021

Kelompok MGMP (Musyawarah Guru Mata Pelajaran) seni budaya SMP se-Kawedanan Jatinom merupakan wadah para guru mata pelajaran seni budaya untuk meningkatkan mutu dan kualitas pembelajaran dalam mempersiapkan dan melaksanakan kegiatan belajar mengajar di sekolah. Dalam kelompok ini dilatarbelakangi oleh guru-guru seni budaya dengan berbagai disiplin ilmu. Keterbatasan disiplin ilmu tentunya tidak seharusnya menjadi kendala dalam memberikan materi pembelajaran di kelas, apalagi dalam penyampaian materi pembelajaran seni grafis. Tujuan dari penelitian ini, mengoptimalkan kompetensi guru seni budaya di SMP se-Kawedanan Jatinom dalam mengajarkan materi seni grafis kepada siswa. Metode pencarian  data yang digunakan dalam penelitian ini adalah metode kualitatif, data diperoleh dengan cara  observasi langsung, dokumentasi, kuesioner, wawancara dengan informan. Subjek dari penelitian ini yaitu guru seni budaya SMP se-Kawedanan Jatinom, Klaten, Jawa Tengah yang pernah atau sedang memberikan materi seni grafis di kelas IX semester II dengan latar belakang disiplin ilmu seni rupa. Luaran dari penelitian ini akan disusun buku bahan ajar seni grafis bagi guru seni budaya SMP. Dengan bahan ajar tersebut diharapkan para guru dapat menambah ilmu tentang seni grafis dan dapat dengan mudah diajarkan kepada siswa. Penelitian ini diharapkan dapat bermanfaat dalam mengembangkan ilmu pengetahuan seni grafis kepada guru dan siswa sejak dini, sehingga nantinya seni grafis lebih dikenal masyarakat luas.
‟L’Amor che move il sole e l’altre stelle…" ovvero l’italianistica come strumento ausiliare nella letteratura comparata
Authors: Płaszczewska Olga
Published: May 2021

Abbracciando la questione dell’utilità dell’italianistica nello studio comparato delle lettere, l’osservazione riguarda il problema dell’irradiarsi della cultura italiana nella civiltà europea attraverso temi e immagini comuni, la sua funzione ispiratrice per il corpus transnazionale di generi e di modelli artistici, e infine, l’intervento si riferisce anche al significato della letteratura e dell’arte italiana per la memoria culturale contemporanea, in particolare quella polacca, anch’essa ispirata da Dante.„Miłość, co wprawia w ruch słońce i gwiazdy…”, albo italianistyka jako narzędzie pomocnicze komparatystyki literackiejZłożony z pięciu fragmentów szkic poświęcony jest roli i znaczeniu kompetencji italianistycznych w warsztacie komparatystycznym. Rozpiętość italotematycznych badań porównawczych wskazują kolejno: refleksja nad tradycją podróży włoskiej (obejmująca problematykę intertekstualności, promieniowania wzorców literackich i artystycznych, zagadnienie „mitu Italii” i italianizmu w różnych epokach literackich), ze szczególnym uwzględnieniem włoskich wątków pisarstwa Stanisława Vincenza; następnie rozważania dotyczące genologii (tradycja sonetu i oktawy w literaturze polskiej) oraz przekładu jako obszarów wzajemnego oddziaływania literatur (w tym polskiej jako przyjmującej włoskie modele literackie – przypadek Juliusza Słowackiego – i oddziałującej na piśmiennictwo włoskie – przypadek Wisławy Szymborskiej). Odrębnym sygnalizowanym wątkiem jest zagadnienie recepcji Dantego w polskiej (i europejskiej) tradycji kulturowej (petrarkizm Felicjana Faleńskiego; fascynacje polskich romantyków Boską komedią).
Prevalência de necrose tecidual após aplicação de ácido hialurônico
Authors: Dos Reis Maria Angélica Otero de Melo , Rabelo Ana Júlia Moreno , Téo Ana Sara Negre , Cardoso Giulia Dalla Bernardina , Guerra Marcela Scardua Zanotti , Rua Mariana Olympio , Bicalho Mariana Reis Chaves , Araujo Martina Barina , Vasconcelos Tawany Tavares Santos , Gandra Milena Ferreira
Published: May 2021

Objetivo: Analisar a produção científica recente sobre a necrose tecidual após a aplicação de ácido hialurônico, explorando a epidemiologia, patogênese, prevenção e tratamento desta complicação. Revisão bibliográfica: Constatou-se que a ocorrência de complicações após a aplicação de ácido hialurônico não é frequente e a maior parte dos eventos adversos são leves e autolimitados. Apesar de rara, a necrose tecidual desencadeada por preenchimento com ácido hialurônico é grave e importante, no entanto, as evidências são muito escassas quanto ao tratamento ideal. Para não desencadear o agravamento do problema, deve-se, a partir dos primeiros sinais e sintomas (dor, branqueamento da pele ou alterações de cor na distribuição do vaso sanguíneo regional), interromper imediatamente a aplicação e injetar hialuronidase o mais precoce possível, associado a compressas mornas e massagem local, para tentar aumentar o fluxo sanguíneo e dissolver o êmbolo. Considerações finais: No presente estudo, pode-se observar a importância do conhecimento profundo da anatomia vascular da face, bem como o treinamento adequado de médicos que usam preenchimentos injetáveis, visto que esse procedimento tem se tornado crescente nos consultórios de dermatologia.
Computational Load Balancing Method for Hybrid Computing Systems
Authors: Баранова Татьяна Петровна , Бугеря Александр Борисович , Ефимкин Кирилл Николаевич
Published: May 2021

The paper considers the issues of the computations distributing within one node of a hybrid computing system for applied programs with computation-intense operations. A method is proposed for static distribution of computations, as well as a method for automatic balancing of the computational load during program execution, which is based on periodic analyzing the CPU load by the executed program and making decision to redistribute computational load if necessary. The proposed methods are implemented in an applied program that solves a gas dynamic problem using the computing resources of the multicore central processor and graphics accelerators. The results of program execution with various data distributions were obtained and analyzed, both with and without the mechanism for automatic balancing of the computational load.
A REVIEW: MODELS COSTING QUALITY AND ITS IMPACT ON THE PLANNING AND CONTROL PROCESSES IN MANUFACTURING INDUSTRIES
Authors: Asada Riyadh Y. , Kumar Yathish , Al-Hubaishi Dr. Wahib
Published: May 2021

In today's world, industrial organizations must pay attention to policies and procedures that balance cost and quality in production processes. Therefore, it must adopt a framework that enables it to accumulate the CoQ. The purpose of this work is to understand CoQ analysis's philosophy, its impact on the planning, control processes in industrial companies, the mechanism of reporting in the financial report, its importance in reducing costs, and enhancing competitive advantages. Also, this work intended to complement the existing literature by reviewing and critically appraising several CoQ models together with details of their application. The study results show that conformity costs are subject to Control. Planning processes are the costs of conformity as for the expenses of non-conformity, cannot be avoided. In general, every philosophy and approach views quality from its perspective. Still, everyone agrees that the product must meet the customer's needs, requirements, and desires.
MINI REVIEW: THE APPLICATION OF BRAIN-COMPUTER INTERFACES IN ROBOTIC THERAPY
Authors: Farzaneh Mohammad Mehdi
Published: May 2021

The idea of robotic therapy has been considered as a possible rehabilitation strategy to facilitate recovery of the patients with disability and it can represent an efficient treatment. Brain-computer interface (BCI) is known as an advanced technology with great potential in therapeutic and assistive robots. This paper is presented to review the application of BCI in rehabilitation robotic systems through the combination of BCI with electroencephalography (EEG) and functional electrical stimulation (FES). For this purpose, the basic concept of each of BCI, EEG, and FES is introduced to give a general view of their function. In addition, the application of EEG-BCI and FES-BCI systems in therapeutic and assistive treatments is showed by providing a summary of different researches for each field. In the end, this document is terminated with a discussion about the arguments behind the studied topics and the future directions of advances in robotic therapy.
Manisa Ulu Cami ve Medresesi’nde Yeni Keşfedilen Devşirme Taş Eserler
Authors: TOK Emine
Published: May 2021

Manisa Ulu Camii ve Medresesi’nde 2018 tarihinde başlayan restorasyon çalışmaları, Ulu Cami’nin gerek mimari planı, gerek cephe düzeni gerekse inşa malzemesine yönelik yeni veriler sunmuştur. Çalışmamızda, Manisa Ulu Camii ve Medresesi’nde yeni keşfedilen Bizans ve öncesi dönemlere ait devşirme malzemenin ilk kez bilim dünyasına tanıtılması ve değerlendirilmesi amaçlanmıştır. Yeni bulgularla, yapıda inşa malzemesi olarak kullanılan devşirme malzemeye 22 adet eser daha eklenmiştir. Sütun, sütun başlığı, sütun kaidesi, postament, lento, templon arşitravı gibi elemanların yanında, yazıtlı bir mermer parçası gibi çeşitli dönemlere ait karışık malzemenin bir arada kullanıldığı tespit edilmiştir. Eserlerden ikisi harim içinde, biri avluda yapılan zemini tespit etmek amacıyla yapılan araştırma kazıları sırasında bulunmuştur. Diğer parçaların ağırlıklı olarak harim kuzey duvarında, doğrudan caminin orijinal plan tasarımına mimari öğeler olarak dahil edildiği görülmüştür. Tespitlerimizden biri, Saruhanoğulları Beyliği bünyesinde çalışan, alanlarında ehil Müslüman taş ustalarının, orijinalde postament veya impost olarak üretilmiş eserleri, son derece pratik çözümlemelerle İslami kimlik kazandırarak sütun başlığına dönüştürmeleri olmuştur. Harim kuzey duvarında ortaya çıkan iki sütun başlığı ise bugüne dek literatürde Korinth başlıkların özel gurubu altında incelenen tipin (S-Sarmal Volütlü Başlıklar) dağılım alanına Manisa’nın da yeni bir merkez olarak eklenmesi açısından son derece önemli verilerdir.
acceso a la educación superior como derecho humano
Authors: Terán Suárez Román José Luis
Published: May 2021

Este trabajo analiza los aspectos centrales del acceso a la educación superior como derecho humano, desde la proclamación de la Declaración Universal de Derechos Humanos de 1948. El estudio se centra en la problemática de la exclusión educativa de los grupos más pobres en términos socioeconómicos, a partir de la vigencia de la Constitución de la República del Ecuador del 2008 y la Ley Orgánica de Educación Superior. A partir de este fundamento, el objetivo es realizar un análisis crítico-reflexivo en torno al funcionamiento del Sistema de Educación Superior en Ecuador, sobre la base de las reglas que ofrece la ley antes citada. Para ello, se empleó una metodología cualitativa centrada en la revisión bibliográfica documental. La información obtenida, permitió determinar los principales documentos doctrinales y legales que han permitido cumplir con el objetivo. A partir de ello, se demostró, en efecto, el ordenamiento jurídico ecuatoriano es insuficiente para garantizar el ejercicio efectivo de la igualdad de oportunidades, en función de los méritos respectivos, a fin de acceder a una formación académica y profesional con producción de conocimiento pertinente y de excelencia y que, por lo tanto, otras estrategias adicionales son imperiosas si se busca garantizar el acceso y la permanencia de estos sectores desprotegidos en el sistema de educación superior.
protección y garantía constitucional para el deporte ecuatoriano
Authors: Pérez Valverde Jorge Washington
Published: May 2021

La protección y garantía constitucional para el deporte ecuatoriano, surge como una exigibilidad, que es la facultad de reclamar por diferentes mecanismos el cumplimiento de los derechos. El deporte es un derecho humano que se encuentra en la categoría de los derechos económicos, sociales y culturales, puesto que, es necesario para el desarrollo, la salud y el bienestar tanto de los individuos como de la sociedad. Las formas en que se puede plantear la exigibilidad de este derecho son a través de mecanismos sociales, políticos y legales. Esto conlleva a estimular la práctica de experiencias deportivas auténticas, en las que, los deportistas indistintamente de su condición tienen las mismas oportunidades en las diferentes disciplinas deportivas y desarrollan competencias, conscientes de las ventajas del deporte. La práctica deportiva como un factor influyente en el desarrollo físico e intelectual desde una cosmovisión centrada en el desarrollo de valores requiere que la educación física a nivel de formación en deporte y recreación motive y oriente la reflexión crítica, el trabajo productivo y la comunicación, lo cual, contribuye a la formación de una verdadera conciencia como parte del desarrollo integral.
medidas cautelares constitucionales en Ecuador
Authors: Terán Suárez Román José Luis
Published: May 2021

Este trabajo analiza los aspectos centrales de las medidas cautelares constitucionales en Ecuador, como mecanismos que favorecen el acceso de las personas a la justicia y a una tutela judicial efectiva de sus derechos. El estudio se centra en el período 2008-2020, a partir de la vigencia de la Constitución de la República del Ecuador del 2008 y la Ley Orgánica de Garantías Jurisdiccionales y Control Constitucional, que tiene por objeto regular la jurisdicción constitucional, con el fin de garantizar jurisdiccionalmente los derechos reconocidos en la Constitución y en los instrumentos internacionales de derechos humanos. A partir de este fundamento, el objetivo es realizar un análisis crítico-reflexivo en torno al funcionamiento del procedimiento cautelar constitucional en Ecuador a partir de las reglas que ofrecen las leyes antes referidas. Para ello, se empleó una cualitativa, en el que la revisión bibliográfica – documental fue el principal método. Se aplicó un fichaje bibliográfico, que permitió determinar los principales documentos doctrinales y legales. A partir de ello, se demuestra el ordenamiento jurídico ecuatoriano reconoce las medidas cautelares constitucionales, las que poseen una connotación diferente a la cautela ordinaria, por la naturaleza del derecho que protegen. No se profundiza en casos concretos, por lo que es meritorio continuar su tratamiento por los jueces constitucionales.