bluuebunny/crossref_metadata_2025 huggingface dataset:
The Regulatory Hierarchy Following Signal Integration by the CbrAB Two-Component System: Diversity of Responses and Functions
Authors: Monteagudo-Cascales Elizabet , Santero Eduardo , Canosa Inés
Published: February 2022

CbrAB is a two-component system, unique to bacteria of the family Pseudomonaceae, capable of integrating signals and involved in a multitude of physiological processes that allow bacterial adaptation to a wide variety of varying environmental conditions. This regulatory system provides a great metabolic versatility that results in excellent adaptability and metabolic optimization. The two-component system (TCS) CbrA–CbrB is on top of a hierarchical regulatory cascade and interacts with other regulatory systems at different levels, resulting in a robust output. Among the regulatory systems found at the same or lower levels of CbrAB are the NtrBC nitrogen availability adaptation system, the Crc/Hfq carbon catabolite repression cascade in Pseudomonas, or interactions with the GacSA TCS or alternative sigma ECF factor, such as SigX. The interplay between regulatory mechanisms controls a number of physiological processes that intervene in important aspects of bacterial adaptation and survival. These include the hierarchy in the use of carbon sources, virulence or resistance to antibiotics, stress response or definition of the bacterial lifestyle. The multiple actions of the CbrAB TCS result in an important competitive advantage.
Epigenetic and Epitranscriptomic Control in Prostate Cancer
Authors: López Judith , Añazco-Guenkova Ana M. , Monteagudo-García Óscar , Blanco Sandra
Published: February 2022

The initiation of prostate cancer has been long associated with DNA copy-number alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations, especially those of the Androgen Receptor. Non-mutational events, particularly DNA and RNA epigenetic dysregulation, are emerging as key players in tumorigenesis. In this review we summarize the molecular changes linked to epigenetic and epitranscriptomic dysregulation in prostate cancer and the role that alterations to DNA and RNA modifications play in the initiation and progression of prostate cancer.
Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome
Authors: Hassan Saqib , Kaakinen Marika A. , Draisma Harmen , Zudina Liudmila , Ganie Mohd A. , Rashid Aafia , Balkhiyarova Zhanna , Kiran George S. , Vogazianos Paris , Shammas Christos , Selvin Joseph , Antoniades Athos , Demirkan Ayse , Prokopenko Inga
Published: February 2022

Polycystic ovary syndrome (PCOS) is a very common endocrine condition in women in India. Gut microbiome alterations were shown to be involved in PCOS, yet it is remarkably understudied in Indian women who have a higher incidence of PCOS as compared to other ethnic populations. During the regional PCOS screening program among young women, we recruited 19 drug naive women with PCOS and 20 control women at the Sher-i-Kashmir Institute of Medical Sciences, Kashmir, North India. We profiled the gut microbiome in faecal samples by 16S rRNA sequencing and included 40/58 operational taxonomic units (OTUs) detected in at least 1/3 of the subjects with relative abundance (RA) ≥ 0.1%. We compared the RAs at a family/genus level in PCOS/non-PCOS groups and their correlation with 33 metabolic and hormonal factors, and corrected for multiple testing, while taking the variation in day of menstrual cycle at sample collection, age and BMI into account. Five genera were significantly enriched in PCOS cases: Sarcina, Megasphaera, and previously reported for PCOS Bifidobacterium, Collinsella and Paraprevotella confirmed by different statistical models. At the family level, the relative abundance of Bifidobacteriaceae was enriched, whereas Peptococcaceae was decreased among cases. We observed increased relative abundance of Collinsella and Paraprevotella with higher fasting blood glucose levels, and Paraprevotella and Alkalibacterium with larger hip, waist circumference, weight, and Peptococcaceae with lower prolactin levels. We also detected a novel association between Eubacterium and follicle-stimulating hormone levels and between Bifidobacterium and alkaline phosphatase, independently of the BMI of the participants. Our report supports that there is a relationship between gut microbiome composition and PCOS with links to specific reproductive health metabolic and hormonal predictors in Indian women.
Leveraging Gene-Level Prediction as Informative Covariate in Hypothesis Weighting Improves Power for Rare Variant Association Studies
Authors: Ji Ying , Chen Rui , Wang Quan , Wei Qiang , Tao Ran , Li Bingshan
Published: February 2022

Gene-based rare variant association studies (RVASs) have low power due to the infrequency of rare variants and the large multiple testing burden. To correct for multiple testing, traditional false discovery rate (FDR) procedures which depend solely on P-values are often used. Recently, Independent Hypothesis Weighting (IHW) was developed to improve the detection power while maintaining FDR control by leveraging prior information for each hypothesis. Here, we present a framework to increase power of gene-based RVASs by incorporating prior information using IHW. We first build supervised machine learning models to assign each gene a prediction score that measures its disease risk, using the input of multiple biological features, fed with high-confidence risk genes and local background genes selected near GWAS significant loci as the training set. Then we use the prediction scores as covariates to prioritize RVAS results via IHW. We demonstrate the effectiveness of this framework through applications to RVASs in schizophrenia and autism spectrum disorder. We found sizeable improvements in the number of significant associations compared to traditional FDR approaches, and independent evidence supporting the relevance of the genes identified by our framework but not traditional FDR, demonstrating the potential of our framework to improve power of gene-based RVASs.
Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer
Authors: Ljubić Sven , Sermek Antonio , Prgomet Sečan Angela , Prpić Marin , Jakšić Blanka , Murgić Jure , Fröbe Ana , Ugarković Đurđica , Feliciello Isidoro
Published: February 2022

The aberrant overexpression of alpha satellite DNA is characteristic of many human cancers including prostate cancer; however, it is not known whether the change in the alpha satellite RNA amount occurs in the peripheral tissues of cancer patients, such as blood. Here, we analyse the level of intracellular alpha satellite RNA in the whole blood of cancer prostate patients at different stages of disease and compare it with the levels found in healthy controls. Our results reveal a significantly increased level of intracellular alpha satellite RNA in the blood of metastatic cancers patients, particularly those with metastatic castration-resistant prostate cancer relative to controls. In the blood of patients with localised tumour, no significant change relative to the controls was detected. Our results show a link between prostate cancer pathogenesis and blood intracellular alpha satellite RNA levels. We discuss the possible mechanism which could lead to the increased level of blood intracellular alpha satellite RNA at a specific metastatic stage of prostate cancer. Additionally, we analyse the clinically accepted prostate cancer biomarker PSA in all samples and discuss the possibility that alpha satellite RNA can serve as a novel prostate cancer diagnostic blood biomarker.
Telehealth and Artificial Intelligence Insights into Healthcare during the COVID-19 Pandemic
Authors: El-Sherif Dina M. , Abouzid Mohamed , Elzarif Mohamed Tarek , Ahmed Alhassan Ali , Albakri Ashwag , Alshehri Mohammed M.
Published: February 2022

Soon after the coronavirus disease 2019 pandemic was proclaimed, digital health services were widely adopted to respond to this public health emergency, including comprehensive monitoring technologies, telehealth, creative diagnostic, and therapeutic decision-making methods. The World Health Organization suggested that artificial intelligence might be a valuable way of dealing with the crisis. Artificial intelligence is an essential technology of the fourth industrial revolution that is a critical nonmedical intervention for overcoming the present global health crisis, developing next-generation pandemic preparation, and regaining resilience. While artificial intelligence has much potential, it raises fundamental privacy, transparency, and safety concerns. This study seeks to address these issues and looks forward to an intelligent healthcare future based on best practices and lessons learned by employing telehealth and artificial intelligence during the COVID-19 pandemic.
Alcohol Consumption by Italian and Spanish University Students in Relation to Adherence to the Mediterranean Diet and to the Food Neophobia: A Pilot Study
Authors: Aiello Paola , Peluso Ilaria , Villaño Valencia Débora
Published: February 2022

This work aimed to relate alcohol consumption with adherence to the Mediterranean diet (MD) and with food neophobia (FN) among Italian and Spanish university students. Volunteers (n = 194, 108 Italian and 86 Spanish), recruited at the La Sapienza University of Rome and the Catholic University of Murcia, filled in standardized questionnaires to evaluate alcohol consumption (AUDIT), FN (FN Scale: FNS), and adherence to the MD (MDS-14, MED-55, QueMD). In addition to the previously reported QueMD sub-score (aMED), a sub-score for non-typical MD foods (ntMED, carbonated and/or sugar-sweetened beverages (soft drinks), butter, margarine, or cooking cream, and manufactured sweets, pastries, and cakes) was evaluated. Italian females had higher MED-55 and FNS scores, and a lower AUDIT score than Spaniards (p < 0.01). Students who stayed with their family (resident) were more adherent to MD than those who moved away from home. Resident Italians consumed less beer, hard liquors, and cocktails than Spaniards on Saturday nights (p < 0.01). There were negative correlations between AUDIT and QueMD (R squared: 0.137, p < 0.05), and AUDIT and ntMED (R squared: 0.201, p < 0.01) in Spaniards, however, there was no relationship between AUDIT and other MD scores. In conclusion, this pilot study suggests that non-typical MD foods and Saturday night consumptions, related to being far from home, have a great impact on alcohol consumption.
The Effect of the Schroth Rehabilitation Exercise Program on Spinal and Feet Alignment in Adolescent Patients with Idiopathic Scoliosis: A Pilot Study
Authors: Park Jaeyong , So Wi-Young
Published: February 2022

Background: This study investigated the therapeutic effects of 12-week Schroth rehabilitation exercises (SRE) in improving Cobb’s angle, scoliometer readings, lumbar lordosis, and the calcaneal valgus angle of patients with idiopathic scoliosis. Methods: This pilot study included 60 adolescent patients diagnosed with idiopathic scoliosis by a rehabilitation physician based on a Cobb’s angle of ≥10° using total anteroposterior plain radiography. Patients were classified into groups with a Cobb’s angle of 10–19° (G1), 20–29° (G2), and ≥30° (G3). Cobb’s angle, scoliometer readings, lumbar lordosis, and calcaneal valgus angles were analyzed before and after the 12-week SRE. Results: SRE improved Cobb’s angle (−6.85), scoliometer readings (−2.80), lumbar lordosis (4.23), and calcaneal valgus angles (left, −3.76; right, −2.83) regardless of the initial scoliosis angle, and within-group changes were significant (p < 0.001). In this study, participants in all three groups had undergone SRE, regardless of initial scoliosis severity, and the findings were significant. Conclusion: SRE can be used for patients with idiopathic scoliosis to improve asymmetric musculoskeletal morphology and the patient’s quality of life.
Identification of Suitable Reference Genes for qRT-PCR Normalization in Kiwifruit
Authors: Zhou Yuanjie , Xia Hui , Liu Xinling , Lin Zhiyi , Guo Yuqi , Deng Honghong , Wang Jin , Lin Lijin , Deng Qunxian , Lv Xiulan , Xu Kunfu , Liang Dong
Published: February 2022

Reference genes are used for the correction of qRT-PCR data, and it is necessary to investigate the optimum reference gene under certain conditions. The expression levels of seven traditional reference genes ACT1, ACT2, GAPDH, 18S rRNA, UBQ, TUB and CYP were analyzed using qRT-PCR in different varieties, tissues, developmental stages and hormone (or pollen polysaccharide) treatments in kiwifruit. Gene expression stability was assessed with the help of three common software (geNorm, NormFinder, BestKeeper), and the minimum number of reference genes necessary for normalization was also determined. GAPDH, ACT1 and ACT2 were selected as reference genes for different genotypes of kiwifruit. GAPDH and UBQ were the best combinations of reference genes for root, stem, leaf, flower and fruit. GAPDH and ACT1 could be the preferred reference genes for normalization of qRT-PCR data during fruit development. The pairing of ACT1 and UBQ constituted the optimal combination of reference genes in kiwifruit treated with different hormones (or pollen polysaccharide). This study provides a new and reliable option for the use of reference genes in the analysis of gene expression patterns of interest in kiwifruit.
Underutilized Fruit Crops of Indian Arid and Semi-Arid Regions: Importance, Conservation and Utilization Strategies
Authors: Meena Vijay Singh , Gora Jagan Singh , Singh Akath , Ram Chet , Meena Nirmal Kumar , Pratibha  , Rouphael Youssef , Basile Boris , Kumar Pradeep
Published: February 2022

Nowadays, there is a large demand for nutrient-dense fruits to promote nutritional and metabolic human health. The production of commercial fruit crops is becoming progressively input-dependent to cope with the losses caused by biotic and abiotic stresses. A wide variety of underutilized crops, which are neither commercially cultivated nor traded on a large scale, are mainly grown, commercialized and consumed locally. These underutilized fruits have many advantages in terms of ease to grow, hardiness and resilience to climate changes compared to the major commercially grown crops. In addition, they are exceptionally rich in important phytochemicals and have medicinal value. Hence, their consumption may help to meet the nutritional needs of rural populations, such as those living in fragile arid and semi-arid regions around the world. In addition, local people are well aware of the nutritional and medicinal properties of these crops. Therefore, emphasis must be given to the rigorous study of the conservation and the nutritional characterization of these crops so that the future food basket may be widened for enhancing its functional and nutritional values. In this review, we described the ethnobotany, medicinal and nutritional values, biodiversity conservation and utilization strategies of 19 climate-resilient important, underutilized fruit crops of arid and semi-arid regions (Indian jujube, Indian gooseberry, lasora, bael, kair, karonda, tamarind, wood apple, custard apple, jamun, jharber, mahua, pilu, khejri, mulberry, chironji, manila tamarind, timroo, khirni).
Molecular and Metabolic Changes under Environmental Stresses: The Biosynthesis of Quality Components in Preharvest Tea Shoots
Authors: Liu Jianjun , Wen Beibei , Liu Xiaobo , Yang Yun , Li Meifeng , Wang Xiaojing
Published: February 2022

Severe environments impose various abiotic stresses on tea plants. Although much is known about the physiological and biochemical responses of tea (Camellia sinensis L.) shoots under environmental stresses, little is known about how these stresses impact the biosynthesis of quality components. This review summarizes and analyzes the changes in molecular and quality components in tea shoots subjected to major environmental stresses during the past 20 years, including light (shade, blue light, green light, and UV-B), drought, high/low temperature, CO2, and salinity. These studies reveal that carbon and nitrogen metabolism is critical to the downstream biosynthesis of quality components. Based on the molecular responses of tea plants to stresses, a series of artificial methods have been suggested to treat the pre-harvest tea plants that are exposed to inhospitable environments to improve the quality components in shoots. Furthermore, many pleiotropic genes that are up- or down-regulated under both single and concurrent stresses were analyzed as the most effective genes for regulating multi-resistance and quality components. These findings deepen our understanding of how environmental stresses affect the quality components of tea, providing novel insights into strategies for balancing plant resistance, growth, and quality components in field-based cultivation and for breeding plants using pleiotropic genes.
Influence of Drought Stress on Growth and Essential Oil Yield of Ocimum Species
Authors: Mulugeta Sintayehu Musie , Radácsi Péter
Published: February 2022

A pot experiment was conducted to assess the effect of drought stress on growth and secondary compound accumulation of Ocimum species, in a semi-controlled greenhouse during the year 2020. The experiment was performed as a factorial that was based on a randomized complete design with three species of basil namely O. basilicum ‘Genovese’, O. x africanum, and O. americanum, and three levels of water supply (70, 50, and 30% soil water capacity-SWC) that were replicated twice. The results revealed that severe drought conditions (30% SWC) significantly lowered the relative water content and, as a consequence, plants were shorter, narrower in the canopy, and produced smaller leaves which, in turn, resulted in a 50% fresh and dry herb yield loss. Furthermore, severe drought stress negatively affected the essential oil content (except O. x africanum where no change was seen), essential oil yield, and the antioxidant capacity. However, slight enhancements of glandular hair density were observed in the drought treatment than in the control. Regardless of the soil water capacity variation, the major compound of the essential oil and total polyphenol content remained unchanged. Besides drought, morphological and chemical variations were also detected among the Ocimum species. Sweet basil cultivar Genovese produced the maximum biomass (344.7 g/plant) whereas O. x africanum accumulated higher essential oil (2.79%). The major compounds that were identified were linalool in O. basilicum; 1, 8-cineole, and camphor in O. x africanum; and O. americanum had more neral and geranial. In conclusion, a higher water supply is recommended for higher biomass and essential oil yield production in the tested basil species.
The We Can Quit2 Smoking Cessation Trial: Knowledge Exchange and Dissemination Following a Community-Based Participatory Research Approach
Authors: Castello Stefania , Darker Catherine , Vance Joanne , Dougall Nadine , Bauld Linda , Hayes Catherine B.
Published: February 2022

Background: ‘We Can Quit2’ pilot randomised controlled trial determined the feasibility [of conducting a community-based trial of We Can Quit, a peer-delivered stop-smoking programme (group support, combination nicotine replacement therapy (NRT), and tailored individual support) for women living in socioeconomically disadvantaged areas in Ireland. Lessons from a knowledge exchange (KE) workshop that reengaged trial stakeholders are presented. Methods: The trial dissemination plan included invitation of community, regional and national stakeholders (n = 176) to a KE interactive workshop, who received an accessible brief beforehand. Trial findings were presented. Enhancements to community engagement, participants’ recruitment and retention, and policy priorities arising from the research were discussed. Field notes and responses to a post-event anonymous questionnaire were analysed using thematic content analysis. Results: Workshop attendees (41/176, 23%) recommended: dedicated additional time to engage community stakeholders; social prescribing pathways to enhance recruitment; more adaptation of trial-related information and assistance in completion of data forms for low literacy individuals; encouraging women to join healthy community programmes to facilitate retention and sustainability; removal of barriers to access NRT; and ongoing provision of cessation services tailored to disadvantaged groups. Conclusions: The findings are relevant to the implementation of other community-based health interventions for disadvantaged groups, to policy makers and to service providers.
Effects of Pre-Collegiate Sport Specialization on Cognitive, Postural, and Psychological Functions: Findings from the NCAA-DoD CARE Consortium
Authors: Chou Tsung-Yeh , Caccese Jaclyn B. , Huang Yu-Lun , Glutting Joseph J. , Buckley Thomas A. , Broglio Steven P. , McAllister Thomas W. , McCrea Michael A. , Pasquina Paul F. , Kaminski Thomas W.
Published: February 2022

Background: Early sport specialization has been associated with an increased risk of musculoskeletal injuries and unfavorable psychological outcomes; however, it is unknown whether sport specialization is associated with worse cognitive, postural, and psychological functions in first-year collegiate student-athletes. Methods: First-year collegiate multisport (MA) and single-sport (SA) student-athletes were identified using a pre-collegiate sport experience questionnaire. The cognitive, postural, and psychological functions were assessed by the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT), Standardized Assessment of Concussion (SAC), Balance Error Scoring System (BESS), and Brief Symptom Inventory 18 (BSI-18). Results: MA student-athletes performed higher in cognitive outcomes (e.g., higher ImPACT visual memory composite scores [ß = 0.056, p < 0.001]), but had higher psychological distress (e.g., higher BSI-18 global severity index [ß = 0.057, p < 0.001]) and no difference in postural stability (p > 0.05) than SA student-athletes. Conclusions: This study indicated first-year collegiate athletes with a history of sport specialization demonstrate lower cognitive performance but decreased psychological distress and no differences in static postural stability as compared to their MA counterparts. Future studies should consider involving different health measures to better understand the influence of sport specialization on overall physical and mental health.
Psychosocial Predictors of Body Weight Congruence in Adolescents Aged 15 and 17 Years in Poland: Findings from the Health Behaviour in School-Aged Children (HBSC) Study
Authors: Dzielska Anna , Woynarowska Magdalena
Published: February 2022

Background: Body weight congruence (BWC) has implications for adolescent health. The main goal of this study was to examine the distribution of BWC and its relationship with six psychosocial factors. Methods: A representative sample of N = 3508 adolescents aged 15 and 17 years (52.4% girls) derived from the Health Behaviour in School-aged Children study, conducted in 2017/2018 in Poland, was used. BWC groups were defined based on self-reported BMI and subjective assessment of weight: (1) correct perception; (2) overestimation, and (3). underestimation. Principal component analysis (PCA) extracted the following two factors: a socio-relational factor (SR) related to perceived social support and social self-efficacy, and a body attitudes and social media exposure factor (BAME). Using the total sample, multinomial logistic regression was applied to estimate their impact on the BWC, and gender-specific models were compared. Results: Half (48.6%) of the adolescents correctly estimated their body weight, 31.0% overestimated it (girls 43.9%, boys 17.1%), and 20.0% underestimated it (boys 37.2%, girls 9.0%). Overestimation of body weight concerns 48.0% of normal weight girls, 50.0% of underweight girls, and 21.3% and 32.1% of normal weight and underweight boys, respectively. The percentage of normal weight (34.4%), and overweight and obese (30.8%) boys who underestimated their body weight was three times higher than the respective percentages of girls that underestimated their weight (9.0% and 11.9%). The SR factor protected adolescents from both underestimation (only in girls) and overestimation in the total sample (OR 0.74, 95%CI 0.68–0.81) and both genders. BAME increased this risk of overestimation in both genders (OR = 1.83, 95%CI 1.67–2.0), and the risk of underestimation among boys. Conclusions: Prevention programmes should include a wide range of psychosocial factors to improve BWC among adolescents.
Suicide Attempts and Suicides as a Result of Poisoning and under the Influence of Xenobiotics in Poland in 1999–2020
Authors: Staniszewska Anna , Lasota Dorota , Kielan Aleksandra , Brytek-Matera Anna
Published: February 2022

Background: The most common method of suicide in Poland is hanging, especially among men. However, women tend to overdose on medications to commit suicide. Considering suicide attempts, poisoning, which involves overdosing various substances, is the most commonly used method. The purpose of the present study was to analyze suicide attempts by intoxication, suicides, and substances that influenced the state of consciousness of suicide victims in Poland in the years covered by the study. Methods: A descriptive analysis was made based on the data obtained from the registers of the General Police Headquarters of Poland and the Statistics Poland for the years 1999–2020. Results: During the 21-year study period, 161,655 cases of suicide attempts were recorded in Poland, 106,169 of which resulted in suicides. Results showed that out of 14,660 self-poisoning suicide attempts, there were 2258 cases of suicide poisoning deaths in the analyzed study period. According to the data of the General Police Headquarters of Poland, the total number of suicides of all causes was 106,169. Self-poisoning suicides accounted for 2.1% of all cases of suicides. Conclusion: Due to the distribution of suicide registration systems in Poland, data available in this area should be interpreted with caution.
The Impact of Treated Wastewater Irrigation on the Metabolism of Barley Grown in Arid and Semi-Arid Regions
Authors: Alvarez-Holguin Alan , Sosa-Perez Gabriel , Ponce-Garcia Omar Castor , Lara-Macias Carlos Rene , Villarreal-Guerrero Federico , Monzon-Burgos Carlos Gustavo , Ochoa-Rivero Jesus Manuel
Published: February 2022

The use of treated wastewater (TWW) for irrigation has gained global attention since it reduces pressure on groundwater (GW) and surface water. This study aimed to evaluate the effect of TWW on agronomic, photosynthetic, stomatal, and nutritional characteristics of barley plants. The experiment with barley was established on two bands: one band was irrigated with GW and the other with TWW. The evaluation was performed 25, 40, 60, 90, and 115 days after sowing (DAS). Results showed that irrigation with TWW increased (p < 0.01) grain yield by 54.3% and forage yield by 39.4% compared to GW irrigation. In addition, it increased plant height (PH) (p = 0.013), chlorophyll concentration index (CCI) (p = 0.006), and leaf area index (LAI) (p = 0.002). TWW also produced a positive effect (p < 0.05) in all the photosynthetic efficiency parameters evaluated. Barley plants irrigated with TWW had lower stomatal density (SD) and area (SA) (p < 0.001) than plants irrigated with GW. Plants irrigated with TWW had a higher P concentration (p < 0.05) in stems and roots and K concentration in leaves than plants irrigated with GW. We concluded that the use of TWW induced important biochemical, physiological, and agronomic changes in barley plants. Hence, the use of TWW may be a sustainable alternative for barley production in arid and semi-arid regions. This study was part of a government project, which aimed to develop a new metropolitan irrigation district with TWW. This study may contribute to the sustainability of water resources and agricultural practices in northern Mexico.
Psychometric Properties of the Urdu Translation of Berg Balance Scale in People with Parkinson’s Disease
Authors: Kashif Muhammad , Ahmad Ashfaq , Bandpei Muhammad Ali Mohseni , Gilani Syed Amir , Iram Humaira , Farooq Maryam
Published: February 2022

Background: The most common assessment tool used in clinical settings to detect changes in balance performance is the Berg Balance Scale (BBS). Thus, the purpose of this study was to translate the BBS into Urdu and investigate the psychometric properties (acceptability, internal consistency reliability, interrater reliability, construct validity) for individuals with Parkinson’s disease (PD). Methods: Eighty patients of either gender with idiopathic Parkinson’s disease, stages I–III on the modified Hoehn–Yahr (H&Y) scale, with intact cognition according to the Mini Mental Score Examination (MMSE) score (greater than or equal to 24) and independent of transfers, were included in this study. The BBS was translated according to international guidelines based on forward and backward translation processes. The test-retest reliability as well as intra- and inter-observer reliability was assessed by calculating the intra-class correlation coefficient (ICC). The internal consistency of the entire BBS score was assessed by calculating Cronbach’s α. The convergent validity was assessed by correlating the scale with the Unified Parkinson Disease Rating Scale (UPDRS) parts II and III and the Activity-specific Balance Confidence Scale (ABCS). The construct validity was assessed using a factor analysis. Results: The mean age of the subjects was 62.35 ± 5.74 in years (range: 60–87 years). The ICC for intra- and inter-observer reliability was 0.95 (p < 0.0001) and 0.99 (p < 0.001), respectively. Cronbach’s α was calculated as 0.81, which showed acceptable internal consistency of the Urdu version of the BBS. The test-retest reliability (ICC) of the Urdu version of the BBS was determined as 0.97 for the total score, and ranged from 0.66–0.95 for individual items. In terms of validity, the Urdu version of the BBS was correlated with the ABCS (in the positive direction) and UPDRS-II and III (in the negative direction) (r = 0.53, p < 0.001; r = −0.68, p < 0.001, r = −0.78, p < 0.0001), respectively. Conclusion: The Urdu version of the BBS is a reliable and valid scale to be used in balance assessment of population diagnosed with PD with excellent psychometric properties.
Self-Reported Coping Strategies for Managing Work-Related Stress among Public Safety Personnel
Authors: Anderson Gregory S. , Ricciardelli Rosemary , Tam-Seto Linna , Giwa Sulaimon , Carleton R. Nicholas
Published: February 2022

Public safety personnel (PSP) experience a disproportionately high number of on-the-job stressors compared to the general population. PSP develop self-initiated actions, or coping strategies, that either confront the situation (approach strategies) or avoid the situation (avoidance strategies) to reduce the impact of stressors on their well-being. Understanding how PSP cope with stress is critical to ensuring their safety and that of the public. In the current study, we examined the coping strategies of PSP (n = 828 in the total sample). Participants managed their experiences of occupational stress or distress using three primary approach coping strategies: education (learning about mental illness and their causes), self-reliance (processes of self-reflection), and treatment (pharmaceutical, psychotherapy) that were considered adaptive. Results demonstrate PSP used multiple coping strategies simultaneously to deal with occupational stress. PSP who reported doing better tended to attribute their success to treatment, specifically psychotherapy, either alone or in combination with other interventions, and almost always emphasizing important supports from co-workers, families, and friends. Changing workplace culture could help to de-pathologize the effects of stress reactions being perceived as individual “failings”.
Aging with HIV: Increased Risk of HIV Comorbidities in Older Adults
Authors: Roomaney Rifqah Abeeda , van Wyk Brian , Pillay-van Wyk Victoria
Published: February 2022

With improved access to antiretroviral treatment (ART), adults with HIV live longer to reach older age. The number of older adults living with HIV is increasing steadily, giving rise to a new population of interest in HIV research and for invigorated considerations in health service delivery and policy. We analysed the profile of comorbidities in older people (50 years and older) living with HIV in South Africa. We conducted a secondary analysis of all individuals over 15 years who tested HIV positive in the Fifth South African National HIV Prevalence, Incidence, Behaviour and Communication Survey, 2017. We conducted multivariate logistic regression to determine the factors associated with having HIV comorbidity using Stata 15.0 software. We entered 3755 people living with HIV into the analysis, of whom 18.3% (n = 688) were 50 years or older. Older adults had four times greater odds (OR = 4.7 (3.1–7.0)) of having an HIV comorbidity compared to younger adults. Being female (OR = 1.6 (1.1–2.4)) and living in an urban area (OR = 2.6 (1.8–3.7)) increased the odds of HIV comorbidity. Older adults with HIV require comprehensive health care to deal with multimorbidity, to maximise the benefits gained by advances in HIV therapies.
Rise of Social Media Influencers as a New Marketing Channel: Focusing on the Roles of Psychological Well-Being and Perceived Social Responsibility among Consumers
Authors: Kim Jihye , Kim Minseong
Published: February 2022

This empirical research investigated the structural relationships between social media influencer attributes, perceived friendship, psychological well-being, loyalty, and perceived social responsibility of influencers, focusing on the perspective of social media users. More specifically, this study conceptually identified social media influencer attributes such as language similarity, interest similarity, interaction frequency, and self-disclosure and examined the respective effects of each dimension on perceived friendship and psychological well-being, consequently resulting in loyalty toward social media influencers. The authors collected and analyzed data from 388 social media users in the United States via Amazon’s Mechanical Turk with multivariate analyses to test the hypothesized associations among the variables in this study. The findings indicated that perceived friendship was significantly influenced by language similarity, interest similarity, and self-disclosure, but did not have a significant impact on psychological well-being. Additionally, perceived friendship significantly affected psychological well-being and loyalty, and psychological well-being significantly influenced loyalty. Lastly, social media influencers’ social responsibility moderated the path from psychological well-being to loyalty. Based on these findings, this study proposes theoretical and managerial implications for the social media influencer marketing context.
Epidemiology and Risk Factors of Delayed Sputum Smear Conversion in Malaysian Aborigines with Smear-Positive Pulmonary Tuberculosis
Authors: Ibrahim Muhammad Naim , Nik Husain Nik Rosmawati , Daud Aziah , Chinnayah Thilaka
Published: February 2022

Background: Tuberculosis (TB) remains a serious public health challenge despite enormous eradication efforts. Indigenous groups worldwide have a higher TB incidence and associated delayed sputum–smear conversion. The aim of this case–control study was to determine the epidemiology and factors associated with delayed sputum–smear conversion among Malaysian aborigines. Methods: We used secondary data from 2016 to 2020 in the MyTB surveillance system. Malaysian aborigines with smear-positive pulmonary TB were enrolled and followed until the end of the intensive phase. Descriptive statistics and multiple logistic regression were used for data analysis. Results: Of 725 Malaysian aborigines with pulmonary TB, 572 (78.9%) were smear-positive and 487 (78.9%) fulfilled the study criteria. The mean (SD) age of smear-positive pulmonary TB was 39.20 (16.33) years. Majority of participants were male (63%), Senoi tribe (54.9%), living in rural areas (88.1%), formally educated (60.4%) and living below the poverty line (97.1%). Overall, 93 (19.1%) of 487 patients showed delayed sputum-smear conversion and significantly associated factors, such as smoking (AdjOR: 3.25; 95% CI: 1.88, 5.59), diabetes mellitus (AdjOR: 12.84; 95% CI: 6.33, 26.06), and HIV infection (AdjOR: 9.76; 95% CI: 3.01, 31.65). Conclusions: Stakeholders should adopt targeted approaches to tackle the problem of aboriginal groups with pulmonary TB and these associated risk factors to realise the End TB target.
The Carbon Emission Assessment of a Building with Different Prefabrication Rates in the Construction Stage
Authors: Han Qingye , Chang Junjie , Liu Guiwen , Zhang Heng
Published: February 2022

The utilization of prefabricated components is taken as a potential way to reduce carbon emissions from the construction industry, and the prefabrication rate may be a factor that influences the mitigation efficiency. This study develops an assessment method to compare carbon emissions of a building in the construction stage when it is built with multiple different prefabrication rates. Firstly, two carbon sources (building materials and machineries) and three construction sub-phases (production of materials and components, transportation, and on-site construction) are determined to clarify the calculation boundary. Then, a carbon emission measurement model for prefabricated buildings in the construction stage is developed by using a process-based method. A dormitory building in Chongqing, China, is selected to conduct a case study to show the application of the provided model. The result shows that the carbon emission of prefabricated buildings is higher compared to that of traditional cast-in situ buildings. Moreover, the emission of prefabricated buildings decreased slightly with the increase in the prefabrication rate. A detailed discussion is followed to investigate the reason why the carbon emission does not decrease with the utilization of prefabricated units. Based on the discussion, some suggestions are given to improve the carbon emission reduction efficiency of prefabrication techniques.
An Update on Planned Oocyte Cryopreservation (POC) in Italy: Medical, Epidemiological and Legal Consideration
Authors: Cremonese Jessica , Marcon Marianna , Oppi Laura , Paletti Giulia , Romolo Vincenzo , Tozzo Pamela , Caenazzo Luciana
Published: February 2022

Starting with a brief socioeconomic analysis of the phenomenon of female fertility, this narrative review aims to provide an analysis of the use and possibilities of medically assisted reproductive technology in combating fertility issues, adopting socioeconomic, legal and medical perspectives in Italy. The authors mainly employ data from the annual reports of the National Registry of Medically Assisted Reproduction (PMA Registry) and the Italian Statistical Institute (ISTAT) to understand the evolution of oocyte use in medically assisted reproductive technology in Italy from 2015 to 2018 and in particular to dissect the possibilities of oocyte cryopreservation as a measure to counteract age-related infertility, specifically through Planned Oocyte Cryopreservation (POC), also known as “social freezing”. It seems that the best course of action in the context of medically assisted reproduction would be the use of young and healthy cryopreserved oocytes (autologous or donated), preferably before the age of 40, while encouraging donation of oocytes whenever possible. Italy’s dependence on foreign biobanks for donated oocytes calls for the institution of a national biobank and further specific regulation of gamete donation. For this reason, it would be useful to encourage the acceptance of Planned Oocyte Cryopreservation to allow greater availability of healthy, younger oocytes.
How Socio-Economic Drivers Explain Landscape Soil Erosion Regulation Services in Polish Catchments
Authors: Istanbuly Mustafa Nur , Krása Josef , Jabbarian Amiri Bahman
Published: February 2022

Most studies that address the relationship between socio-economic characteristics and soil erosion focus on the effects of soil erosion on socio-economic conditions at different levels, from global to smallholder. Few, if any, efforts are made to address the influence of socio-economic variables on the soil erosion rate as an indicator of landscape degradation. The present study was carried out using spatial data from 402 catchments that cover Poland, to find out how socio-economic variables, which include area-weighted average income per capita (PLN km−2), area-weighted average gross domestic product (PLN km−2), population density (person km−2), and human development index can drive the soil erosion rate (kg ha−1 yr−1), along with annual precipitation, soil and geomorphological variables that include soil organic carbon content, soil water content, clay ratio, stream gradient, and terrain slope. The results showed that the soil erosion rate is indirectly driven by the socio-economic variables in the study catchments, as it is alleviated by increasing population density, the area-weighted average gross domestic product, and the human development index. Furthermore, analyzing the incremental relationship between soil erosion rate and the area-weighted average of socio-economic variables revealed that no uniform change can be observed in the relationship between the area-weighted average socio-economic variables and soil erosion in the study catchments.
Aging Adults’ Motivation to Use Embodied Conversational Agents in Instrumental Activities of Daily Living: Results of Latent Profile Analysis
Authors: Smrke Urška , Plohl Nejc , Mlakar Izidor
Published: February 2022

The rapidly increasing share of ageing adults in the population drives the need and interest in assistive technology, as it has the potential to support ageing individuals in living independently and safely. However, technological development rarely reflects how needs, preferences, and interests develop in different ways while ageing. It often follows the strategy of “what is possible” rather than “what is needed” and “what preferred”. As part of personalized assistive technology, embodied conversational agents (ECAs) can offer mechanisms to adapt the technological advances with the stakeholders’ expectations. The present study explored the motivation among ageing adults regarding technology use in multiple domains of activities of daily living. Participants responded to the questionnaire on the perceived importance of instrumental activities of daily living and acceptance of the idea of using ECAs to support them. Latent profile analysis revealed four profiles regarding the motivation to use ECAs (i.e., a low motivation profile, two selective motivation profiles with an emphasis on physical and psychological well-being, and a high motivation profile). Profiles were compared in terms of their acceptance of ECA usage in various life domains. The results increase the knowledge needed in the development of assistive technology adapted to the expectations of ageing adults.
Stay in Risk Area: Place Attachment, Efficacy Beliefs and Risk Coping
Authors: Qing Chen , Guo Shili , Deng Xin , Wang Wei , Song Jiahao , Xu Dingde
Published: February 2022

For residents living in earthquake-threatened areas, choosing suitable risk coping behaviors can effectively reduce the loss of family life and property. However, some residents still choose to continue to live within areas at risk of earthquake disaster. Place attachment may play an important role. Based on place attachment theory and the Protective Action Decision Model (PADM), this study explores the possible relationships among place attachment, efficacy beliefs, and evacuation/relocation intention. Furthermore, it examines the mediating role of efficacy beliefs. The study also used the partial least squares method (PLS-SEM) to test samples of 327 rural households in Wenchuan and Lushan earthquake-hit areas. The results show that: (1) Place attachment has a significant effect on response efficacy (RE), but not on self-efficacy (SE); (2) Place dependence (PD) has a negative and significant effect on relocation intention (RI) but has no significant effect on evacuation intention (EI). However, place identity (PI) can indirectly affect EI by influencing RE; (3) Efficacy beliefs have a significant positive effect on EI and RI. These results help us understand the complex relationships among place attachment, efficacy beliefs, and residents’ risk coping behavior, thus providing decision-making references for the formulation and improvement of regional disaster risk management policies.
Socioeconomic Determinants of Universal Health Coverage in the Asian Region
Authors: Takura Tomoyuki , Miura Hiroko
Published: February 2022

The World Health Organization (WHO) states that examining medical financial systems is the most important process in evaluating universal health coverage (UHC). This study used the service coverage index (SCI) as a proxy of the progress toward UHC in eleven Asian countries. We employed a fixed-effects regression model to analyze panel data from 2015 to 2017, to explain the interrelationship between the SCI and major socioeconomic indicators. We also conducted a performance analysis (ratio of achieved SCI level to gross domestic product (GDP) or health expenditure displacement) to examine the balance between the degree of achievements related to UHC and a country’s economic level. The results showed that GDP and health expenditure were significantly positively correlated with the SCI (p < 0.01). The panel data analysis results showed that GDP per capita was a factor that greatly influenced the SCI as well as poverty (partial regression coefficient: 0.0017, 95% CI: 0.0013–0.0021). The results of the performance analysis showed that the Philippines had the highest scores (GDP: 1.84 SCI score/USD per capita, health expenditure: 1.04 SCI score/USD per capita) and South Korea the lowest. We conclude that socioeconomic factors, such as GDP, health expenditure, unemployment, poverty, and population influence the progress of UHC, regardless of system maturity or geographic characteristics.
The Relationship between Dental Fear and Anxiety, General Anxiety/Fear, Sensory Over-Responsivity, and Oral Health Behaviors and Outcomes: A Conceptual Model
Authors: Stein Duker Leah I. , Grager Mollianne , Giffin Willa , Hikita Natasha , Polido José C.
Published: February 2022

Dental fear and anxiety (DFA) is common across the lifespan and represents a barrier to proper oral health behaviors and outcomes. The aim of this study is to present a conceptual model of the relationships between DFA, general anxiety/fear, sensory over-responsivity (SOR), and/or oral health behaviors and outcomes. Two rounds of literature searches were performed using the PubMed database. Included articles examined DFA, general anxiety/fear, SOR, catastrophizing, and/or oral health behaviors and outcomes in typically developing populations across the lifespan. The relationships between the constructs were recorded and organized into a conceptual model. A total of 188 articles were included. The results provided supporting evidence for relationships between DFA and all other constructs included in the model (general anxiety/fear, SOR, poor oral health, irregular dental attendance, dental behavior management problems [DBMP], and need for treatment with pharmacological methods). Additionally, SOR was associated with general anxiety/fear and DBMP; general anxiety/fear was linked to poor oral health, irregular attendance, and DBMP. This model provides a comprehensive view of the relationships between person factors (e.g., general anxiety/fear, SOR, and DFA) and oral health behaviors and outcomes. This is valuable in order to highlight connections between constructs that may be targeted in the development of new interventions to improve oral health behaviors and outcomes as well as the experience of DFA.