bluuebunny/crossref_metadata_2025 huggingface dataset:
Enucleation and Dermato-fat Graft for Retinoblastoma Management : A Case Report
Authors: SIMANJUNTAK Dr. AGNES ANGELA MAHDALENA , Anne Umboh , Freili Akay
Published: February 2024

Introduction : Retinoblastoma is the most common intraocular malignant tumor found in children before 3 years old can occur unilaterally, bilaterally, hereditary or sporadic. Incidence of about 1:14,000-20,000 individuals. This tumor originated from embryogenic retinal cells. Retinoblastoma gene (RB1) located in the 13q14 chromosome

Case Illustration : A 3-year-old girl presented with leukocoria. Her parents notice whitish in her right eye swollen, teary, painful since 2 months ago. No family history. Visual acuity (VA) on the oculus dextra ( OD) no light perception, oculus sinistra (OS) 6/6. Intraocular pressure on OD n-1/palpation, OS n/palpation. Examination under anasthesia for diagnostic found there weren’t palpebral edema, conjunctival injection, hazy cornea, pupil, lens couldn’t be evaluated on OD. Ultrasound showed sugest vitreous seeding and ptisis. CT scan showed solid mass with calcification and diagnosed retinoblastoma stage group E. Patient was treated with chemoreduction using Vincristine, Etoposide, Carboplatine combined enucleation with dermato-fat graft. We did nervus opticus dissection and histopathological examination which showed retinoblastoma.

Discussion : The common signs of retinoblastoma is leukocoria. The priority is saving life followed by globe preservation. Treatment based on the stage of the disease. We did chemotherapy in this patient, followed by enucleation and dermato-fat graft. Enucleation stills the main therapy for saving life with nervus opticus dissection as possible. Dermato-fat graft has been shown to grow along with the expanding orbit in children therefore shows cosmetics.

Conclusion : This report illustrates a case of Retinoblastoma. The chemotherapy and enucleation using safe dermato-fat graft procedure with implant followed by a well fitted prosthesis for better cosmetics
Spontaneous Globe Rupture due to Neglected Glaucoma: How can it be?
Authors: Firdausi Asri Ayu , Kunhermawan Cosmas Hascaryanto , Lestari Chindhia Rima Rochmatika Bunga
Published: February 2024

Introduction: Globe rupture is usually associated with spontaneous traumatic processes with the worst prognosis. The occurrence without prior trauma is only reported in small numbers of cases. This paper will describe a globe rupture in glaucomatous eye and share our experience with its management.

Case Illustration: A 66-year-old male presented to the emergency department (ED) with reddish and progressive pain in the right eye (RE) followed by severe headaches for the last three days. On history taking, the patient complained of a progressive blurry vision to total blindness of his RE for 1 year. The patient admitted to having a history of glaucoma on previous primer examination but did not routinely control it. On initial examination, the patient was hypertensive , and suddenly began bleeding within 10 minutes upon arrival at ED. The diagnosis of globe rupture was made and he underwent emergency evisceration.

Discussiona: Spontaneous globe rupture is very rare, with an incidence of 3 per 100.000 in the United States, while no definite number is found in Indonesia due to the rarity. In glaucoma patients, spontaneous globe rupture is postulated to occur due to suprachoroidal hemorrhage. Our patients had multiple risk factors such as advanced age, systemic hypertension, and chronic untreated glaucoma. Evisceration went down to reduce pain, stop bleeding and prevent the spread of infection. Performing surgery within 10 days of the initial injury suggests a lower risk of post-operative endophthalmitis or sympathetic ophthalmia.

Conclusion: Spontaneous globe rupture in neglected chronic glaucoma has a very poor outcome but preventable.
Peripheral Ulcerative Keratitis: A Serious Corneal Inflammation
Authors: Fitrah  , Havizra Vitresia  , Getry Sukmawati
Published: February 2024

Abstract

Introduction : Peripheral ulcerative keratitis (PUK) is a rare, but severe sight-threatening inflammatory condition that affects the cornea. PUK is characterized by peripheral corneal ulceration, stromal thinning, and neovascularization that can lead to corneal perforation and vision loss. Although PUK can occur in individuals without underlying systemic disease, it is most commonly associated with autoimmune disorders.

Case Illustration : A 53-year-old woman presented to the ophthalmology clinic with complaints of redness, foreign body sensation, and blurred vision in her both eye for the past three days. On examination, slit-lamp biomicroscopy revealed a peripheral corneal ulcer. She had a history of rheumatoid arthritis for the past 2 months and was being treated with methotrexate and metylprednisolone. Laboratory investigations revealed elevated Anti-CCP IgG, which confirmed the presence of rheumatoid arthritis.

Discussion : PUK is most commonly associated with autoimmune disorders, particularly rheumatoid arthritis, but may also occur in individuals with infectious, degenerative or traumatic corneal injuries. Immune- mediated inflammation, complement activation, and tissue destruction are thought to be involved in the pathogenesis of PUK. The diagnosis of PUK requires a thorough ophthalmic examination, including slit-lamp biomicroscopy, and laboratory investigations for underlying autoimmune disorders.

Conclusion : PUK is a rare but serious ocular disease that requires prompt diagnosis and management to prevent severe complications such as corneal perforation and vision loss. Although PUK can occur in individuals without underlying systemic disease, it is most commonly associated with autoimmune disorders, particularly rheumatoid arthritis.
Validity and Reliability of Farra Eye Model as a Surgical Simulator for Capsulorhexis Training
Authors: HANIFAH RAHMANI NURSANTI  , Julie Dewi Barliana  , Syska Widyawati  , Faraby Martha  , Levina Chandra Khoe
Published: February 2024

Abstract

Introduction & Objectives : Various simulation models are available for cataract surgery training. Farra Eye Model, a new cataract surgery simulator, was developed to provide the resident with more affordable options. This study aims to determine the validity and reliability of the Farra Eye Model as a surgical simulator for capsulorhexis training.

Methods : A cross-sectional pilot study was performed among ophthalmology residents and consultants to assess face, content, and construct validity of a new surgical simulator. Subjects were divided into novice, intermediate, and expert groups according to their level of expertise. Face and content validity was assessed using a validated questionnaire with a 5-point Likert scale response. Construct validity was done by comparing capsulorhexis performance between the three groups. Two raters assessed performance using capsulorhexis indices in ICO-OSCAR: Phaco assessment tool, number of forceps grabs, and duration of capsulorhexis.

Results : A total of 33 subjects were recruited and divided equally into three groups. The overall face validity score was favorable (3.67 ± 0.67). However, the capsule elasticity was rated poor (2.73 ± 1.1) among the intermediate group. The content validity was favorable regarding the overall score (4.15± 0.58) and each assessment component. In the construct validity test, intermediate and expert groups showed better capsulorhexis performance than the novice group on all parameters (p<0.001), with good inter-rater reliability (ICC>0.7).

Conclusion : Farra Eye Model has a good face and content validity for capsulorhexis training and is able to differentiate the novice group from intermediate and expert groups. However, it remains a challenge to replicate human lens capsule elasticity.
Sudden Ocular Complication after Snake Bite
Authors: Hadrani Farah Hayati , Oktaputri Anita , Widodo Galih , Susetio Yoseph
Published: February 2024

Introduction : A snakebite constitutes a common acute medical emergency and has several systemic and even ocular consequences. Snake venom neurotoxins act mainly on the peripheral nervous system at the neuromuscular junction and can affect the cranial nerves. Neurological symptoms that relate to cephalic muscle paralysis include exotropia, ptosis, diplopia and ophthalmoplegia.

Case Illustration : A 17 years old man came to emergency department with painful swelling on his left hand and sudden blurred vision right after his left hand were bitten by venomous snake in the rice field. Diplopia and ptosis were developed several hours after admission. On eye examination, visual acuity was 0,05 on right eye and 0,8 on left eye, abnormal pupillary reflects on both eyes were present, pupil dilatation, limited eye movement and ptosis were present, Intraocular pressure were 23,7 mmHg on right eye and 24,5 mmHg on left eye. Antivenom was administered immediately. He received cycloplegic, timolol eyedrop, and prednisolone eyedrop for ocular treatment

Discussion : Ocular complications are rare and uncommon but they may lead to sight-threatening conditions. Snake venom neurotoxins act mainly on the peripheral nervous system at the neuromuscular junction and can affect the cranial nerves. Mild neurological symptoms that relate to cephalic muscle paralysis include exotropia, ptosis, diplopia and ophthalmoplegia.

Conclusion : This study presented a rare case of systemic ocular complication as a result of a snake bite. Ophthalmoplegia induced ocular discomfort for an extended period is a rare symptom of snake-bites. Combined treatment of steroid with antivenom may improve the recovery from sudden ocular manifestation in snake bite.
Predicting Cardiovascular Risk in People With Diabetic Retinopathy : Study Using Framingham Risk Score
Authors: Harahap Vicia Belladona Carolina , Metita Mirza , Dewi Nadia Artha
Published: February 2024

Introduction: People with type 2 diabetes have an increase risk of cardiovascular disease (CVD). Framingham risk score is used to determine 10 years the risk of CVD in asymptomatic patients for primary prevention. Up to now, there have been no similar studies regarding the risk of CVD in diabetic retinopathy (DR) patients in Indonesia. Therefore, we would like to investigate the corelation between DR and CVD risk through the population using Framingham risk score.

Methods: This research is a Population-Based Cross-sectional Study. The data was taken from the villages in Malang Regency. Participant with diabetes aged > 40 was recruited. The available data was then processed according to the variables and assessed using Framingham Risk Score. The scores were classified as high, intermediate, and low risk.

Results: From 953 samples there were 155 respondents with Diabetes Mellitus (DM), 23 of them experience DR. There were more female participants than men in DM group without DR (73.9%) and DR group (73.9%). A significant correlation between diabetic retinopathy and CVD risk was found (r=0.407, p=0.001). The risk of CVD in 10 years is low in diabetic patients without retinopathy ( p=0.001), but in patients with diabetic retinopathy, the risk of CVD in 10 years is intermediate-high (p=0.001).

Conclusion: There is corelation between Diabetic Retinopathy and risk for cardiovascular disease in intermediate-high category using Framingham risk score.
Navigating Through The Diagnostic and Management Maze of Atypical Optic Neuritis Due To Autoimmune
Authors: Andi Marsa Nadhira  , Syntia Nusanti  , Salmarezka Dewiputri  , Sita Paramita  , Muhammad Sidik
Published: February 2024

Abstract

Introduction : Typical and atypical optic neuritis (ON) have many overlapping characteristics; however, atypical ON have different features, with more lasting visual impairment and devastating prognosis. This paper describes a challenging case of recurrent, atypical ON due to autoimmune.

Case Illustration : 42-year-old female complained of recurrent attacks of bilateral blurry vision, eye pain, and headachefor the past two years. Patient had been on multiple rounds of high-dose oral methylprednisolone, but symptoms reappeared every time it was tapered down. Visual acuity of both eyes was 3/60 and 6/45 (without and with correction, respectively), with normal intraocular pressure, anterior and posterior segment, and cranial nerves. No relative afferent pupillary defect was present. Brain magnetic resonance imaging (MRI) revealed intracerebral chronic small vessels; with no lesion in both optic nerves nor signs of neuromyelitis optica. Blood work-up showed elevated C-reactive protein, platelet aggregation, fibrinogen, D-dimer; positive rheumatoid factor, antinuclear antibody, and lupus anticoagulant; and negative Aquaporin-4 IgG. Diagnosis of atypical ON was established. Internal medicine and neurology departments diagnosed her with non-radiographic axial spondyloarthritis and migraine due to attributed autoimmune, respectively. After administration of intravenous pulse dose of methylprednisolone, her vision recovered to 6/7,5 of both eyes and symptoms alleviated.

Discussion : Atypical features usually give hints for atypical ON, while laboratory examination and imaging modalities may aid in etiology identification. Early immunosuppressant therapy is commonly required.

Conclusion : Recognizing symptoms of ON and necessitating further evaluation through ancillary tests, and collaborations with other specialties can minimize long-lived ailment and improve patients’ quality of life.
Surgical Strategies for Divergence Excess: A Comparison of True Divergence Excess and Pseudo-Divergence Excess Cases
Authors: Anshari Harsya Luthfi , Julita
Published: February 2024

Introduction : True divergence excess (True DE) intermitent exotropia (IXT) is characterized by a greater deviation at distance than near ?10 prism diopters, while pseudo-divergence excess (Pseudo-DE) has greater deviation at distance than near but the difference becomes minimal after patching. Bilateral Lateral Recess (BLR) and Monocular Recess Resect (MRR) are commonly chosen for surgical planning.

Case Illustration : Case 1, a 4-year-old female presented with squint since 1 year old. Hirschberg test showed XT 15° in near (N) and 30° in distance (D). Prism alternate cover test (PACT) result was 30 ?D (N) and 60 ?D (D). Case 2, a 4-year-old female presented with squint since 6 months old. Hirschberg test showed XT 30° (N) and 45° (D) and dominant right eye. PACT result was 70 ?D (N) and 80 ?D (D). Poor fusion was found in both cases. Both patients underwent monocular patching for 30 minutes. We diagnosed patient 1 with True DE and BLR was done, while patient 2 with IXT dominant right eye Pseudo-DE and MRR was done on the left eye.

Discussion : First case was a patient with True DE who underwent 8-mm BLR, while second case was Pseudo-DE with dominant right eye who underwent monocular recess 11 mm and resection 8 mm on the left eye. Orthophoria was found after surgical correction in both cases.

Conclusion : Surgery management in True DE and Pseudo-DE are challenging, especially in determining the amount of surgery dosage and it depends on surgeon's experience. Both cases achieved successful outcomes with surgical correction resulted in orthophoria.
Os Desafios do Exercício da Medicina
Authors: Gilson Soares Feitosa
Published: February 2024

O Editorial retrata a importância dos estudos randomizados para o avanço da Medicina, assim como o papel central do médico em sua prática nas soluções do exercício da Medicina.
Avaliação da Expressão das Células NK no Câncer de Próstata após Prostatectomia Radical
Authors: José Abraão Carneiro Neto  , Merson Silva de Almeida  , Isabella Almeida Motta  , Vitor Lucas de Oliveira Pereira  , Ruth Souza Alves  , Luiz Eduardo Café
Published: February 2024

Introdução. O câncer de próstata (CaP) é o segundo câncer mais frequente em homens. Embora avanços tenham ocorrido no entendimento da fisiopatologia do câncer de próstata, ela não foi totalmente compreendida. O surgimento de novas drogas, principalmente imunoterápicos, agregou a necessidade de novos marcadores de doença, já que o PSA se mostra falho, principalmente nos cenários de recidiva. Pacientes com câncer de próstata poderiam exibir padrões de resposta imune diferenciados de acordo com o estadio clínico da doença, com menor efetividade do sistema imune em pacientes com estadio clínico mais grave, traduzindo uma falência do sistema imune efetor em controlar a doença, em particular as células NK. O objetivo deste estudo é revisar sistematicamente estudos que abordem o papel das células NK ou a expressão de tais células em pacientes portadores de câncer de próstata submetidos a prostatectomia radical (PTR). Método. Revisão sistemática de ensaios clínicos e estudos observacionais em humanos em língua inglesa avaliando a população de células NK ou a sua atividade após prostatectomia radical para tratamento de câncer de próstata. Resultados. 13/20 artigos compilados para avaliação foram revisados. Destes, 5 artigos investigaram de fato a contagem das células NK ou a mensuração de sua atividade como fator prognóstico. Observou-se, na maioria dos trabalhos, aumento da população das células NK ou de sua atividade após PTR e uma correlação positiva entre aumento da população de células NK pós-operatória ou da sua expressão e aumento da sobrevida livre de doença/recidiva bioquímica. Conclusão. A maioria dos artigos revisados demonstrou aumento da população de células NK ou da atividade das células NK no pós-operatório de prostatectomia radical. A grande heterogeneidade dos dados e a ausência de estudos robustos, com a avaliação de desfechos já utilizados na prática clínica, reforçam a necessidade de novos estudos sobre o tema.
ANALISIS KINERJA PERUSAHAAN TAHUN 2021-2022 DENGAN METODE EVA PADA PT. ACE HARDWARE INDONESIA.TBK
Authors: August Halomoan Siregar  , Kiton Mario Andrias
Published: February 2024

Realizing good company financial performance is the dream of all companies stakeholders, especially company financial managers, company owners and investors. Financial performance as reported through Financial Reports can be analyzed using various methods including using the Economic Value Added (EVA) method. Recently, many companies have implemented the EVA method as a method for assessing company performance. Economic Value Added (EVA) is a very effective assessment system for assessing a company's financial performance over a certain period. This research aims to analyze the financial performance of the company PT. ACE Hardwared, Tbk uses the Economic Value Added (EVA) method. This research is quantitative descriptive research using secondary data in the form of Financial Reports for the 2021-2022 period obtained from the Indonesia Stock Exchange (BEI). The research results for 2021, 2022 show a positive EVA (>0) so that the company is deemed to have been able to create economic added value after the company paid all of the company's obligations to its investors.
A study on the Linguistic Landscape surrounding the Jangjeon Campus of Pusan National University
Authors:   Urimal Society, Kang Eunji , Kim Taeho
Published: February 2024

This paper aims to investigate the linguistic landscape surrounding Pusan National University through the collection of linguistic data from commercial store signs in the vicinity of the Jangjeon Campus. Since these signs mirror the culture of the university town, we can delineate the characteristics of the area around Pusan National University by examining the types of characters and languages used, as well as the distribution of sign contents based on business types, with the goal of identifying regional peculiarities. The analysis yielded notable findings. Firstly, it was observed that the signage predominantly employs a combination of the Roman alphabet and Hangeul, with the latter being the most prevalent. Secondly, variations in each location were attributed to differences in the market and the primary customer base. Thirdly, instances of shop names incorporating 'pwutae' or 'hyo-won' were identified, signifying their proximity to Pusan National University.
Prima del libretto per musica
Authors: Riccò Laura
Published: February 2024

Partendo dal proto-libretto dell’Orfeo di Striggio (musicato da Monteverdi), stampato in occasione della “prima” del 1607, il saggio analizza le tipologie di ausili per il pubblico che erano in uso durante gli spettacoli cinquecenteschi e primo seicenteschi, anche nell’ambito del “recitar cantando”, prima della nascita del libretto per musica vero e proprio, dopo l’apertura dei teatri pubblici veneziani nel 1637.

 

Starting from the proto-libretto of Striggio's Orfeo (set to music by Monteverdi), printed on the occasion of the “première” in 1607, the essay analyzes the types of aids for the public in use during sixteenth and early seventeenth-century performances, even in the field of "recitar cantando", before the birth of actual libretto for music after the opening of the Venetian public theaters in 1637.
Utilizzo del DOI (Digital Object Identifier) per la diffusione di progetti lessicografici digitali
Authors: Salucci Giovanni
Published: February 2024

Nei progetti lessicografici digitali viene consigliato di utilizzare gli Identificatori persistenti. In questo contributo si esplora l’opportunità di utilizzare il DOI (Digital Object Identifier) come strumento per la diffusione e promozione di un progetto lessicografico digitale, usando Crossref come agenzia di registrazione. Occorre registrare una serie di DOI, in corrispondenza dei vari livelli gerarchici con cui la banca-dati lessicografica è organizzata, prevedendo la compilazione di metadati di qualità e ricchi di informazioni, con l’obiettivo di identificare il sistema più ampio di metadati che possa favorire la diffusione del progetto e massimizzarne l’impatto.
Nell’articolo viene quindi analizzato in dettaglio il tracciato di registrazione del DOI, mettendo in evidenza le informazioni necessarie e consigliate per la diffusione, esemplificando come collocarle nel sistema di tag previsti dallo schema di registrazione.
 
In digital lexicographic projects, the use of persistent identifiers is recommended. This contribution explores the opportunity to adopt Digital Object Identifiers (DOIs) as a tool for the dissemination and promotion of a digital lexicographic project, utilizing Crossref as the registration agency. To achieve maximum dissemination, a series of DOIs need to be registered, corresponding to the various hierarchical levels through which the lexicon database is organized. This necessitates the compilation of high-quality metadata that is rich in information.
This article provides a detailed analysis of the DOI registration process, highlighting the necessary and recommended information for dissemination. It exemplifies how to incorporate this information into the tag system specified by the registration schema.
Concetto e realtà: il metodo della logica combinatoria in Hegel
Authors: Piccini Caterina
Published: February 2024

All’interno del grande problema metodologico sul rapporto tra Logica e Realphilosophie, Hegel identifica come realmente scientifica la comprensione della relazione tra Begriff e Vorstellung, in cui si tratta della rappresentazione come strumento categoriale dove il pensiero è immerso nell’alterità. A partire dalla necessità metodologica di un nesso sistematico tra rappresentazione e concetto, costitutivo di una logica combinatoria, il presente contributo si propone di comprendere quali ragioni sistematico-concettuali hanno portato Hegel nell’Enciclopedia delle scienze filosofiche in compendio (nelle sue edizioni più tarde: 1827,1830) a una rivalutazione della rappresentazione in quanto materia indispensabile e condizione necessaria per la conoscenza. La ripresa hegeliana della Vorstellung come sinonimo del logico immerso nell’alterità porterà a interrogarsi sul modo in cui la nozione di Übersetzung sia idonea a esprimere quella delicata azione svolta dalla coscienza nell’atto di far assumere ai propri contenuti una forma filosofica, consentendo di comprendere tutti i gradi della Realphilosophie come momenti di una logica della rappresentazione. Muovendo da tali osservazioni sarà necessario domandarsi se e in che senso la logica combinatoria possa essere considerata una semplice trasposizione del concetto nella rappresentazione o la messa in atto della componente concettuale che nella rappresentazione si volge all’esperienza.
 
Within the methodological problem of the relationship between Logic and Realphilosophie, Hegel identifies as truly scientific the understanding of the relationship between Begriff and Vorstellung. In that relationship, representation is treated as a categorical instrument where thought is immersed in otherness. Starting from the methodological necessity of a systematic link between representation and concept, constitutive of a combinatory logic, the present contribution aims to understand what systemic-conceptual reasons led Hegel in the Encyclopaedia of the Philosophical Sciences in Compendium (in its later editions: 1827,1830) to a re-evaluation of representation as an indispensable subject and necessary condition for knowledge. The Hegelian revival of Vorstellung as a synonym for the logical immersed in otherness will then lead to questioning how the notion of Übersetzung is suitable for expressing that delicate action performed by consciousness in the act of making its contents take on a philosophical form, making it possible to understand all the degrees of the Realphilosophie as moments of a logic of representation. On the basis of these observations, it will finally be necessary to ask whether and in what sense combinatorial logic can be considered as a simple transposition of the concept into representation or as the implementation of the conceptual component that in representation turns to experience.
Does a computer think if no one is around to see it?
Authors: Stoica Ovidiu Cristinel
Published: February 2024

I show that a computer cannot have unambiguous thoughts, not even about a number. What we believe computers do is our own convention. It may seem objective because we anchor it in the user interface. But many other conventions are possible, and they yield different computations, equally valid according to the principles of Computer Science. I prove that the alternative computations equally happen when a single computation is carried out, and in principle they can be accessed. I exemplify this with a program that computes the result for a given input, and then decodes it into the results for all other possible inputs. If thinking would be a computation, a computer would have different, possibly opposite thoughts, corresponding to many alternative computations it implements at the same time. I show probabilistically that the human mind does not have this ambiguity. Therefore, even if the human mind can be simulated by a computer, it cannot be reduced to computation.
A Multiply-And-Max/min Neuron Paradigm for Aggressively Prunable Deep Neural Networks
Authors: Prono Luciano , Bich Philippe , Boretti Chiara , Mangia Mauro , Pareschi Fabio , Rovatti Riccardo , Setti Gianluca
Published: February 2024

The growing interest in Internet of Things and mobile Artificial
Intelligence applications is pushing the investigation on Deep Neural
Networks (DNNs) that can operate at the edge using low-resources/energy
devices.

To obtain such a goal, several pruning techniques have been proposed in
the literature. They aim to reduce the number of interconnections - and
consequently the size, and the corresponding computing and storage
requirements - of DNNs that traditionally rely on classic
Multiply-and-ACcumulate (MAC) neurons.

In this work, we propose a novel neuron structure based on a
Multiply-And-Max/min (MAM) map-reduce paradigm, and we show that by
exploiting this new paradigm it is possible to build naturally and
aggressively prunable DNN layers, with a negligible loss in performance.
This novel structure allows a greater interconnection sparsity when
compared to classic MAC-based DNN layers. Moreover, most of the already
existing state-of-the-art pruning techniques can be used with MAM layers
with little to no changes.

To test the pruning performance of MAM, we employ different models -
AlexNet, VGG-16 and the more recent ViT-B/16 - and different computer
vision datasets - CIFAR-10, CIFAR-100 and ImageNet-1K. Multiple pruning
approaches are applied, ranging from single-shot methods to
training-dependent and iterative techniques.

As a notable example, we test MAM on the ViT-B/16 model fine-tuned on
the ImageNet-1K task and apply one-shot gradient-based pruning. We
remove interconnections until the model experiences a 3% decrease in
accuracy. While MAC-based layers need at least 56.16% remaining
interconnections, MAM-based layers achieve the same accuracy with only
0.04%.
Hepatitis B Status in Hemodialysis Patients: An Overview from Morocco
Authors: Mouline Souhail , Hemodialysisbe Rabia Bouna , Alayoud Ahmed , Azizi Mounia
Published: February 2024

Background: Patients with end-stage renal disease, particularly hemodialysis patients are at risk for contracting hepatitis B virus (HBV) because of their compromised immune status and exposure to blood products. Regardless of a shorten in the incidence of HBV infection, surveillance is mandatory in preventing the spread of this dreaded virus. Infection control practices, regular review of serologic markers and hepatitis B vaccination are the cornerstone to maintain a safe environment for dialysis. The aim of our study is to provide an overview of the serologic and vaccination status for hepatitis B in hemodialysis patients. Methods: A cross-sectional study was carried out in our hospital haemodialysis center to evaluate hepatitis B serological status and vaccination profile of chronic kidney disease patients on chronic dialysis program in Agadir, Morocco. Serologic profile results were checked for all patients (anti-HBc, HBsAg and anti-HBs). Individuals without previous vaccination, incomplete vaccination schedule or no serological conversion (anti-HBs <10mUI/ml) have been prescribed hepatitis B vaccine as it is still not available in public health center in Morocco, with a monitoring of adverse events. Results: Fifty-five dialysis patients were included in the study. The majority were male (56,4%), mean age was 59.29 years. All patients were already screened and negative for HBsAg. 69,09% of the population study were vaccinated against hepatitis B (65,78% complete and 34,22% incomplete schedule), with a seroconversion rate of 78,94%. A booster dose of vaccine was given to patients who had not achieve seroconversion (anti HBs <10mUI/ml), because of the immunocompromised state of the dialysis patient. All patients were already screened for anti-HBc. 20% of them were positive, indicating previous contact with the virus. This contact was immunizing in 80 % of patients (anti-HBs>10mUI/ml). For the two patients whose previous contact was not immunizing, the HBV vaccine
The Study of Accuracy of Alvarado Score, CRP, Bilirubin Level and Mean Platelet Volume in the Diagnosis of Acute Appendicitis in a Tertiary Care Centre
Authors: Sarkar Amarendra Nath , Deb Partha Pratim , Islam Mazharul
Published: February 2024

Acute appendicitis is one of the common surgical emergencies and when it progresses to appendicular perforation, morbidity and mortality becomes much higher. Nearly 6% of the population is expected to have appendicitis in their lifetime. Though absolute diagnosis is only possible at operation and histopathological examination of the specimen, many scoring systems are available for the diagnosis of acute appendicitis. Among them Alvarado scoring system is an important one which is based on history, clinical examinations and few laboratory tests. Recent studies have shown the association of hyperbilirubinemia with acute appendicitis and appendicular perforation. Many reports have investigated the value of raised C reactive protein (CRP) and reduced mean platelet volume (MPV) in improving the diagnosis of acute appendicitis. The objective of our study was to evaluate the accuracy of Alvarado scoring system and CRP as a preoperative diagnostic tool in acute appendicitis and to evaluate whether hyperbilirubinemia and reduced MPV has a predictive potential for its diagnosis. A total of one hundred one patients coming to our emergency in a study period of one year were included. It was observed that the sensitivity, specificity, positive predictive value of Alvarado score was 82.7%, 70% and 96%, CRP level- 96.5%, 63.6%, 95.4%, total bilirubin level- 96.4%, 19%, 60.91%, MPV level- 95.7%, 16%, 51.72% respectively and the P value was clinically significant for Alvarado score, CRP level, total bilirubin level but not for MPV. We conclude that Alvarado score, raised total bilirubin level and CRP level are very effective in the diagnosis of acute appendicitis in both men and women but some other diagnostic modality may be necessary to ascertain the diagnosis in females to rule out pelvic pathology and to reduce negative appendicectomy rate.
Giant Cell Tumor of the Tendon Sheaths in the Foot: A Case Report
Authors: Y Bouras, , M Elkaseh, , M Aitrahou, , M Nassiri, , A Achkoun, , M Madhar, , H Elhaoury, , R Chafik,
Published: February 2024

Tendon sheath giant cell tumor (TCGGT) is a benign soft tissue tumor that usually affects the tendons of the hand, but rarely affects the foot. It mainly affects young adults, but can occur between the ages of 10 and 60. It is a predominantly female tumor. Anatomopathological examination remains the key to diagnosis and prognosis. Treatment is based on surgery with complete removal of the tumour. We report a case of a giant cell tumor of the flexor sheaths localized in the sole of the foot.
Surgical Outcomes of Needlescopic Cholecystectomy Versus Laparoscopic Cholecystectomy- A Comparative Study in A Specialized Hospital in Bangladesh
Authors: Begum Mst. Mamtaz , Hossain Mohammad Farid , Rozario Agatha Prianka
Published: February 2024

Background: Needlescopic cholecystectomy (NSC) and laparoscopic cholecystectomy (LC) are both minimally invasive surgical techniques used for the removal of the gallbladder in patients with gallbladder disease, primarily gallstones. The comparison of surgical outcomes between needlescopic cholecystectomy (NSC) and laparoscopic cholecystectomy (LC) has been a subject of interest among surgeons and researchers. Aim of the study: The aim of the study was to compare the surgical outcomes of needlescopic cholecystectomy versus laparoscopic cholecystectomy. Methods: This was a prospective observational study conducted in the Department of General & Laparoscopy Surgery, Evercare Hospital, Dhaka-Bangladesh from December 2022 to November 2023. A total of 50 symptomatic cholelithiasis patients were randomly selected as the study population. The total 50 patients were equally divided into two groups, Group A underwent Needlescopic cholecystectomy, and Group B underwent laparoscopic cholecystectomy. Data analysis was performed using MS Office tools and SPSS version 23.0 program. Results: In this study, intraoperative incidents were less frequent, with 28% in the Needlescopic group and 36% in the Laparoscopic group. Wound length in the epigastrium was significantly smaller in the Needlescopic group (3.9 mm vs. 13.1 mm in Laparoscopic). In the hypochondrium, Needlescopic patients had a 3.7 mm wound, while Laparoscopic patients had 7.9 mm. In the flank region, Needlescopic patients had a 4.2 mm wound, compared to 8.8 mm in Laparoscopic patients. According to a 10-grade VAS scale, satisfaction scores were 9.8 for Needlescopic and 9.6 for Laparoscopic cholecystectomy patients. Conclusion: Needlescopic cholecystectomy has clear advantages over laparoscopic cholecystectomy, with fewer intraoperative incidents, reduced post-operative pain, and smaller wounds, resulting in less discomfort, minimal scarring, and a quicker recovery. Late postoperative complications are also less .........
Severe Acute Asthma, Subcutaneous Emphysema, Pneumomediastinum and Pneumothorax Related to Cocaine: A Rare Clinical Case
Authors: Benjelloun Hanane , Benmerzouq Zineb , Chaanoun Khadija , Zaghba Nahid , Yassine Najiba
Published: February 2024

Cocaine is one of the most widely used and trafficked illicit drugs in the world. Snorted or smoked cocaine can cause a variety of pulmonary complications ranging from bronchospasm to destruction of the alveolar-capillary membrane. We report the case of a 19 year old female patient, asthmatic since the age of 12 with non compliance to treatment, admitted for severe acute asthma associated with soft tissue emphysema, pneumomediastinum and right pneumothorax, secondary to her first consumption of snorted cocaine, requiring intubation and ventilation in intensive care with good radio-clinical evolution under symptomatic treatment.
EVALUASI PENYIMPANAN DAN PENDISTRIBUSIAN VAKSIN COVID-19 DI DINAS KESEHATAN PROVINSI SULAWESI TENGAH
Authors:   Universitas Tadulako, Diana Khusnul , Ekasandra Nur , Tandah Muhamad Rinaldhi
Published: February 2024

The Health Department is responsible for distributing COVID-19 vaccines in the region. This research was conducted to evaluate the suitability of storage and distributionÂ in the warehouse of the Pharmaceutical Installation of the Central Sulawesi Health Department, following the guidelines set in the Director General of Disease Prevention and Control Decision Number Hk.02.02/4/1/2021. The research used observational and qualitative descriptive methods, collecting data within a specific period, using all COVID-19 vaccines stored in the Pharmaceutical Installation of the Central Sulawesi Health Department as the sample. The research results showÂ 8 types of COVID-19 vaccines managed by the Central Sulawesi Health Department, divided into 3 groups: vaccines that must be stored at 2-8 ÂºC, vaccines that must be stored at -20 ÂºC, and vaccines that must be stored at -70ÂºC. All groups of vaccines comply with the guidelines at 100%. However, concerning distribution, the level of compliance hasn't reached 100%. The group of vaccines that must be stored at 2-8 ÂºC, the compliance percentage is 63.64%. Similarly, the group of vaccines that must be stored at -20 ÂºC, the compliance percentage is also 63.64%, and the group of vaccines that must be stored at -70 ÂºC, the compliance percentage reaches 69.23%
EVALUASI KESESUAIAN RESEP OBAT DM PADA PASIEN RAWAT JALAN TERHADAP FORMULARIUM NASIONAL DI RS ARAFAH ANWAR MEDIKA SUKODONO
Authors:   Universitas Anwar Medika, Amarullah Adinugraha , Jannah Ananda Kurniatul , Fickri Djelang Zainuudin ,   Program Studi S1 Farmasi, Fakultas Ilmu Kesehatan, Universitas Anwar Medika, Anwari Farida ,   Program Studi Teknologi Labrotratorium Medika, Fakultas Ilmu Kesehatan, Universitas Anwar Medika
Published: February 2024

Pharmaceutical services are services that are directly responsible to patients in relation to pharmacy. One of the factors that improve the quality of pharmaceutical services is prescription services. In the era of the National Health Insurance (JKN), prescriptions given to patients must refer to the National Formulary. If the prescription is not in accordance with the National Formulary, it will affect the quality of pharmacy installation services. Arafah Anwar Medika Hospital is one of the hospitals with a large number of patients diagnosed with diabetes and requires proper management of drug use. The purpose of this study was to determine the suitability and discrepancy of prescribing with the National Formulary for outpatient Diabetes Mellitus BPJS patients at Arafah Anwar Medika Sukodono Hospital. This research is a non-experimental descriptive study using quantitative research methods, purposive sampling technique with 384 data on all DM prescriptions for outpatient BPJS patients in 2021. not in accordance with FORNAS 2.86%. The conclusion is that a good pharmacy service quality will get a high percentage of prescription conformity with the National Formulary.
PENGARUH PEMBERIAN EDUKASI DENGAN MEDIA VIDEO TERHADAP TINGKAT PENGETAHUAN MASYARAKAT KUIN CERUCUK BANJARMASIN DALAM MENGELOLA OBAT RUSAK DAN KEDA LUWARSA mmmmmmmjk
Authors:   Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Borneo Lestari, Mahrita Mahrita , Saputera Mochammad Maulidie Alfiannor ,   Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Borneo Lestari, Kurniawan Guntur
Published: February 2024

In daily life, people use and store medicines at home for self-medication. Medicines that are stored and not used properly can cause drug damage and drugs to accumulate until the expiration date. The purpose this study was to determine the effect of providing education with video media on knowledge in managing damaged and expired drugs in the Kuin Cerucuk Banjarmasin Village community. This study used a pre-experimental research design with a One Group Pretest Posttest approach. The number of respondents this study were 100 respondents who met the inclusion and exclusion criteria. Data collection used a validated knowledge questionnaire and sampling was done door to door. The results study shows the level of knowledge before being given education with video media, namely the good category 9%, the sufficient category 46% and the less category 45%. While the level of knowledge after being given education with video media 80% good category, 20% sufficient category and 0% lacking category. Based on non-parametric tests using Wilcoxon test, it is known that the p value = 0.000 with a significance level <0.05, which means that there a significant (real) influence between the level of knowledge before and after being given education through video media.
Customer Segmentation in IT Sector using Datamining Techniques
Authors: Kalai Selvi T , Sasirekha S , Deepika N , Kanagalakshmi V , Kavya R
Published: February 2024

Due to its large client base, the IT industry generates enormous amounts of data every day. Business experts and decision-makers stressed that keeping current clients is less expensive than acquiring new ones. Business analysts and customer relationship management (CRM) analysts must understand the causes of customer attrition as well as the patterns of behavior found in the data of these clients. This research is a comprehensive study about churn prediction in IT industry it also suggests a churn prediction model to identify consumer churn and provide the reasons behind customer churn in the IT industry by employing clustering and classification algorithms. Information gain and correlation attribute ranking filters are used in feature selection. One of the CRM's most important tasks is to create retention strategies that work to keep customers from leaving. The study intends to create a model that can effectively identify the primary reasons behind customer churn. This model is likely to use various techniques, such as analyzing customer behavior, preferences, or other relevant data, to identify patterns or characteristics associated with churn and segment the churning customers based on groups in order to retain the customers based on the specific characteristics or behaviors they share within their respective groups. The main aspect of the study is to identify the challenges in the existing methods that are used in churn prediction and suggest a model to improve churn prediction and elude churn effectively.
Machine Learning Driven Smart Transportation Sharing
Authors: Shangaranarayanee N. P , Aakashbabu V , Balamurugan M , Gokulraj R
Published: February 2024

In many urban areas, traffic congestion has become one of the most challenging issues of modern life, resulting in detrimental effects on the environment, productivity loss, fuel wastage, and longer travel times. As a solution, people are increasingly turning to shared transportation modes due to the convenience of multi-modal journeys facilitated by smart transportation systems. The last mile problem refers to the fact that, in large cities, buses and trains deliver passengers to transit stations close to retail and job areas, leaving them needing another form of transportation to reach their final destination. By promoting the use of public transportation and addressing this issue, a smart bike-sharing system can contribute to reducing traffic congestion. The study presents a review of various methods that are associated with the designing of the bike sharing system and suggests a model incorporating various methods to derive solutions, with a focus on utilizing clustering algorithms for the analysis of the provided time series dataset. The study reveals that the application of algorithms such as the K-Means algorithm, Fuzzy C-means, etc. would be very effective in visualizing the resulting clusters and improve the forecasting accuracy.
USE OF COMBINED ORAL CONTRACEPTIVES AND THE RISK OF CERVICAL CANCER IN YOUNG WOMEN
Authors: Filho Danillo Gondim da Silva , Martins Gabriela de Souza , Santos Luan Bernardino Montes , Campos Isabela Sousa , Junior Valdivino Soares de Oliveira , Soares Erika dos Santos , Leit Soraya de Souza Marques , Soares Natascha de Prado , Cruz Thays Souza , Bitanti Rafael Martins , Souza Cristiana Daniela de , Ribeiro Bruna Martins , Borges Daniella Afonso , Júnior Leandro Rezende de Souza
Published: February 2024

The relationship between the use of combined oral contraceptives and the risk of cervical cancer in young women has been the subject of intense scrutiny in the scientific literature. This topic, which is extremely important for women's health, has sparked debates and investigations due to the prevalence of the use of these contraceptives and the significant incidence of cervical cancer in young women. Understanding this possible association is crucial to inform contraceptive practices and cervical cancer prevention strategies. Objective: To evaluate and consolidate the available evidence on the relationship between the use of combined oral contraceptives and the risk of cervical cancer in young women, using studies and articles published in the last 10 years. Methodology: strictly adhered to the PRISMA checklist, using the PubMed, Scielo and Web of Science databases to identify relevant studies. The selected descriptors were combined oral contraceptives, cervical cancer, young women, risk and association. The search covered articles published in the last 10 years. The inclusion criteria included studies that focused exclusively on young women, directly investigated the relationship between the use of combined oral contraceptives and cervical cancer, and were published in the last 10 years. On the other hand, studies with participants outside the specific age range, research that did not directly address the association in question and articles that were not fully available or did not qualify as systematic reviews or primary studies were excluded. This methodological approach provided a comprehensive and careful analysis of the existing evidence on the topic. Results: 18 articles were selected. Analysis of studies revealed a diversity of perspectives on the association between combined oral contraceptives and cervical cancer risk in young women. Key topics included possible biological mechanisms, variations in the types of contraceptives used, and the influence of confounding factors. Conclusion: Given the complexity of the data analyzed, this review highlights the need for careful approaches in interpreting the relationship between combined oral contraceptives and cervical cancer in young women. Future research is crucial to fully clarify this association and provide more precise guidance for clinical practice.