bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization and Function Analysis of Soluble Dietary Fiber Obtained from Radish Pomace by Different Extraction Methods
Authors: Tan Xiqian , Cheng Xiaoxiao , Ma Bingyu , Cui Fangchao , Wang Dangfeng , Shen Ronghu , Li Xuepeng , Li Jianrong
Published: January 2024

Soluble dietary fiber (SDF) benefits human health, and different extraction methods might modify the structure and functions of the SDFs. Radish is rich in dietary fiber. To assess the impact of various extraction techniques on the properties and functions of radish SDF, the SDFs were obtained from white radish pomace using alkaline, ultrasonic-assisted, and fermentation-assisted extraction methods. Analysis was conducted on the structure, physicochemical characteristics, thermal properties, and functional attributes of the SDFs. The study revealed that various extraction techniques can impact the monosaccharides composition and functionality of the SDFs. Compared with the other two extraction methods, the surface structures of SDFs obtained by fermentation-assisted extraction were looser and more porous, and the SDF had better water solubility and water/oil holding capacity. The adsorption capacities of glucose and cholesterol of the SDFs obtained from fermentation-assisted extraction were also improved. Wickerhamomyces anomalus YFJ252 seems the most appropriate strain to ferment white radish pomace to acquire SDF; the water holding, oil holding, glucose absorption capacity, and cholesterol absorption capacity at pH 2 and pH 7 have a 3.06, 1.65, 3.19, 1.27, and 1.83 fold increase than the SDF extracted through alkaline extraction method.
Reactivity and Stability of (Hetero)Benzylic Alkenes via the Wittig Olefination Reaction
Authors: Khan Ajmir , Sarwar Mohammed G. , Ali Sher
Published: January 2024

Wittig olefination at hetero-benzylic positions for electron-deficient and electron-rich heterocycles has been studied. The electronic effects of some commonly used protective groups associated with the N-heterocycles were also investigated for alkenes obtained in the context of the widely employed Wittig olefination reaction. It was observed that hetero-benzylic positions of the pyridine, thiophene and furan derivatives were stable after Wittig olefination. Similarly, electron-withdrawing groups (EWGs) attached to N-heterocycles (indole and pyrrole derivatives) directly enhanced the stability of the benzylic position during and after Wittig olefination, resulting in the formation of stable alkenes. Conversely, electron-donating group (EDG)-associated N-heterocycles boosted the reactivity of benzylic alkene, leading to lower yields or decomposition of the olefination products.
The Dimerization and Oligomerization of Alkenes Catalyzed with Transition Metal Complexes: Catalytic Systems and Reaction Mechanisms
Authors: Parfenova Lyudmila V. , Bikmeeva Almira Kh. , Kovyazin Pavel V. , Khalilov Leonard M.
Published: January 2024

Dimers and oligomers of alkenes represent a category of compounds that are in great demand in diverse industrial sectors. Among the developing synthetic methods, the catalysis of alkene dimerization and oligomerization using transition metal salts and complexes is of undoubted interest for practical applications. This approach demonstrates substantial potential, offering not only elevated reaction rates but also precise control over the chemo-, regio-, and stereoselectivity of the reactions. In this review, we discuss the data on catalytic systems for alkene dimerization and oligomerization. Our focus lies in the analysis of how the activity and chemoselectivity of these catalytic systems are influenced by various factors, such as the nature of the transition metal, the ligand environment, the activator, and the substrate structure. Notably, this review particularly discusses reaction mechanisms, encompassing metal complex activation, structural and dynamic features, and the reactivity of hydride intermediates, which serve as potential catalytically active centers in alkene dimerization and oligomerization.
Evaluation of the Impact of Alternanthera philoxeroides (Mart.) Griseb. Extract on Memory Impairment in D-Galactose-Induced Brain Aging in Mice through Its Effects on Antioxidant Enzymes, Neuroinflammation, and Telomere Shortening
Authors: Aon-im Possatorn , Monthakantirat Orawan , Daodee Supawadee , Chulikhit Yaowared , Sriya Nattapatsorn , Boonyarat Chantana , Chumwangwapee Thanut , Khamphukdee Charinya , Kijjoa Anake
Published: January 2024

Aging is a well-known factor that accelerates brain deterioration, resulting in impaired learning and memory functions. This current study evaluated the potential of an extract of Alternanthera philoxeroides (AP), an edible flavonoid-rich plant, to ameliorate D-galactose-induced brain aging in male mice. Chronic administration of D-galactose (150 mg/kg/day) in mice mimicked the characteristics of aging by accelerating senescence via downregulation of the following telomere-regulating factors: mouse telomerase reverse transcriptase (mTERT) and mouse telomeric repeat-binding factors 1 (mTRF1) and 2 (mTRF2). D-galactose also decreased the activities of the antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD), while increasing expression of neuroinflammatory cytokines in the frontal cortex and hippocampus. Daily treatment of D-galactose-induced aging mice with AP at 250 and 500 mg/kg/day or vitamin E (100 mg/kg/day) significantly increased the activities of SOD and CAT, as well as expression of mTERT, mTRF1, and mTRF2, which are involved in telomere stabilization, but decreased the levels of proinflammatory cytokines IL-1β, IL-6, and TNF-α. In the behavioral portion of the study, AP improved aging-related cognitive deficits in short-term memory as shown by the Y-maze task and the novel object recognition test (NORT) and long-term memory as shown by the Morris water maze test (MWMT). The flavones kaempferol-O-glucoside (1), quercetin (2), alternanthin B (3), demethyltorosaflavone D (4), and chrysoeriol-7-O-rhamnoside (5), which could be responsible for the observed effects of AP in the D-galactose-induced aging mice, were identified by HPLC analysis.
On Water Arrangements in Right- and Left-Handed DNA Structures
Authors: Yatsunyk Liliya A. , Neidle Stephen
Published: January 2024

DNA requires hydration to maintain its structural integrity. Crystallographic analyses have enabled patterns of water arrangements to be visualized. We survey these water motifs in this review, focusing on left- and right-handed duplex and quadruplex DNAs, together with the i-motif. Common patterns of linear spines of water organization in grooves have been identified and are widely prevalent in right-handed duplexes and quadruplexes. By contrast, a left-handed quadruplex has a distinctive wheel of hydration populating the almost completely circular single groove in this structure.
Preparation of Progressive Driving Bilayer Polymer-Dispersed Liquid Crystals Possessing a PDLC-PVA-PDLC Structure
Authors: Wu Yongle , Zhao Yuzhen , Wang Dong
Published: January 2024

In this paper, the bilayer polymer-dispersed liquid crystals possessing a PDLC-PVA-PDLC structure were prepared by integrating two monolayer PDLCs. The effect of the polymer mesh size on the electro–optical properties of a bilayer PDLC was investigated by comparing the micro-morphology and electro–optical curves under different polymerization conditions. In addition, the impact of doping MoO2 nanoparticles with surface modification on the comprehensive performance of the bilayer PDLC was further researched. The contrast ratio of the bilayer PDLC prepared under the optimal conditions was improved by more than 90% and still maintained excellent progressive driving performance. Therefore, the development of a bilayer PDLC with optimal electro-optical properties will significantly enhance the technological prospects for the application of PDLC-based devices in smart windows, displays, and flexible devices.
Reactions of Cadmium(II) Halides and Di-2-Pyridyl Ketone Oxime: One-Dimensional Coordination Polymers
Authors: Stamou Christina , Dechambenoit Pierre , Lada Zoi G. , Gkolfi Patroula , Riga Vassiliki , Raptopoulou Catherine P. , Psycharis Vassilis , Konidaris Konstantis F. , Chasapis Christos T. , Perlepes Spyros P.
Published: January 2024

The coordination chemistry of 2-pyridyl ketoximes continues to attract the interest of many inorganic chemistry groups around the world for a variety of reasons. Cadmium(II) complexes of such ligands have provided models of solvent extraction of this toxic metal ion from aqueous environments using 2-pyridyl ketoxime extractants. Di-2-pyridyl ketone oxime (dpkoxH) is a unique member of this family of ligands because its substituent on the oxime carbon bears another potential donor site, i.e., a second 2-pyridyl group. The goal of this study was to investigate the reactions of cadmium(II) halides and dpkoxH in order to assess the structural role (if any) of the halogeno ligand and compare the products with their zinc(II) analogs. The synthetic studies provided access to complexes {[CdCl2(dpkoxH)∙2H2O]}n (1∙2H2O), {[CdBr2(dpkoxH)]}n (2) and {[CdI2(dpkoxH)]}n (3) in 50–60% yields. The structures of the complexes were determined by single-crystal X-ray crystallography. The compounds consist of structurally similar 1D zigzag chains, but only 2 and 3 are strictly isomorphous. Neighboring CdII atoms are alternately doubly bridged by halogeno and dpkoxH ligands, the latter adopting the η1:η1:η1:μ (or 2.0111 using Harris notation) coordination mode. A terminal halogeno group completes distorted octahedral coordination at each metal ion, and the coordination sphere of the CdII atoms is {CdII(η1 − X)(μ − X)2(Npyridyl)2(Noxime)} (X = Cl, Br, I). The trans-donor–atom pairs in 1∙2H2O are Clterminal/Noxime and two Clbridging/Npyridyl; on the contrary, these donor–atom pairs are Xterminal/Npyridyl, Xbridging/Noxime, and Xbridging/Npyridyl (X = Br, I). There are intrachain H-bonding interactions in the structures. The packing of the chains in 1∙2H2O is achieved via π-π stacking interactions, while the 3D architecture of the isomorphous 2 and 3 is built via C-H∙∙∙Cg (Cg is the centroid of one pyridyl ring) and π-π overlaps. The molecular structures of 1∙2H2O and 2 are different compared with their [ZnX2(dpkoxH)] (X = Cl, Br) analogs. The polymeric compounds were characterized by IR and Raman spectroscopies in the solid state, and the data were interpreted in terms of the known molecular structures. The solid-state structures of the complexes are not retained in DMSO, as proven via NMR (1H, 13C, and 113Cd NMR) spectroscopy and molar conductivity data. The complexes completely release the coordinated dpkoxH molecule, and the dominant species in solution seem to be [Cd(DMSO)6]2+ in the case of the chloro and bromo complexes and [CdI2(DMSO)4].
Magnetic Anisotropy of Homo- and Heteronuclear Terbium(III) and Dysprosium(III) Trisphthalocyaninates Derived from Paramagnetic 1H-NMR Investigation
Authors: Kormschikov Ilya D. , Polovkova Marina A. , Kirakosyan Gayane A. , Martynov Alexander G. , Gorbunova Yulia G. , Tsivadze Aslan Yu.
Published: January 2024

1H-NMR spectroscopy of lanthanide complexes is a powerful tool for deriving spectral–structural correlations, which provide a clear link between the symmetry of the coordination environment of paramagnetic metal centers and their magnetic properties. In this work, we have first synthesized a series of homo- (M = M* = Dy) and heteronuclear (M ≠ M* = Dy/Y and Dy/Tb) triple-decker complexes [(BuO)8Pc]M[(BuO)8Pc]M*[(15C5)4Pc], where BuO- and 15C5- are, respectively, butoxy and 15-crown-5 substituents on phthalocyanine (Pc) ligands. We provide an algorithmic approach to assigning the 1H-NMR spectra of these complexes and extracting the axial component of the magnetic susceptibility tensor, χax. We show how this term is related to the nature of the lanthanide ion and the shape of its coordination polyhedron, providing an experimental basis for further theoretical interpretation of the revealed correlations.
Synthetic Studies toward 5,6,7,3′,4′-Monomethoxytetrahydroxyflavones: Synthesis of Pedalitin
Authors: Kamma Koteswara Rao , Cho Joungmo , Won Hyo Jun , Nam So-Yeon , Le Ngan Hong , Jung Je Hyeong , Lee Kee-In
Published: January 2024

During the synthetic studies toward 5,6,7,3′,4′-monomethoxytetrahydroxyflavones, a concise pedalitin synthesis procedure was achieved. As previously reported, 6-hydroxy-2,3,4-trimethoxyacetophenone was prepared by Friedel–Crafts acylation of 1,4-dihydroxy-2,6-dimethoxybenzene with boron trifluoride diethyl etherate in acetic acid. When aldol condensation of 6-hydroxy-2,3,4-trimethoxyacetophenone 2b with vanillin was performed in basic conditions, it produced 2′-hydroxychalcone 3b, and, surprisingly, along with 3-hydroxyflavone 4 in a considerable amount. We propose that this oxidative cyclization is presumably due to the contribution of a quinone methide, likely to be subjected to aerobic oxidation. The chalcone was then subjected to oxidative cyclization with iodine in dimethyl sulfoxide to afford flavone 5 in good yield. To our delight, serial demethylation of the three methoxy groups at the 5-, 6-, and 3′-positions of 5 proceeded smoothly to produce pedalitin 1, under hydrogen bromide solution (30% in acetic acid). The crystal structures of 3-hydroxyflavone 4 and pedalitin tetraacetate 6 were unambiguously determined by X-ray crystallography.
PNPT1 Spectrum Disorders: An Underrecognized and Complex Group of Neurometabolic Disorders
Authors: Sgobbi Paulo , Farias Igor Braga , Serrano Paulo de Lima , Badia Bruno de Mattos Lombardi , Oliveira Hélvia Bertoldo de , Barbosa Alana Strucker , Pereira Camila Alves , Moreira Vanessa de Freitas , Chieia Marco Antônio Troccoli , Barbosa Adriel Rêgo , Fraiman Pedro Henrique Almeida , Braga Vinícius Lopes , Machado Roberta Ismael Lacerda , Calegaretti Sophia Luiz , Fernandes Isabela Danziato , Ribeiro Roberta Correa , Orsini Neves Marco Antonio , Pinto Wladimir Bocca Vieira de Rezende , Oliveira Acary Souza Bulle
Published: January 2024

An 18-year-old man presented with slowly progressive infancy-onset spasticity of the lower limbs and cerebellar ataxia, associated with painless strabismus, intellectual disability, urinary incontinence, bilateral progressive visual loss, and cognitive decline since early adolescence. A neurological examination disclosed spastic dysarthria, left eye divergent strabismus, bilateral ophthalmoparesis, impaired smooth pursuit, severe spastic paraparesis of the lower limbs with global brisk tendon reflexes, bilateral extensor plantar responses, and bilateral ankle clonus reflex. Bilateral dysdiadochokinesia of the upper limbs, Stewart-Holmes rebound phenomenon, bilateral dysmetria, and a bilateral abnormal finger-to-nose test were observed. Markedly reduced bilateral visual acuity (right side 20/150, left side 20/400) and moderate to severe optic atrophy were detected. Neuroimaging studies showed cerebellar atrophy and bilateral optic nerves and optic tract atrophy as the main findings. As a complicated Hereditary Spastic Paraplegia, autosomal dominant Spinocerebellar Ataxia, or inherited neurometabolic disorders were suspected, a large next-generation sequencing-based gene panel testing disclosed the heterozygous pathogenic variant c.162-1G>A in intron 1 of the PNPT1 gene. A diagnosis of PNPT1-related spastic ataxia was established. Clinicians must be aware of the possibility of PNPT1 pathogenic variants in cases of spastic ataxia and spastic paraplegias that are associated with optic atrophy and marked cognitive decline, regardless of the established family history of neurological compromise.
RNA N6-Methyladenosine Affects Copper-Induced Oxidative Stress Response in Arabidopsis thaliana
Authors: Sharma Bishwas , Govindan Ganesan , Li Yongfang , Sunkar Ramanjulu , Gregory Brian D.
Published: January 2024

Recently, post-transcriptional regulation of mRNA mediated by N6-methyladenosine (m6A) has been found to have profound effects on transcriptome regulation during plant responses to various abiotic stresses. However, whether this RNA modification can affect an oxidative stress response in plants has not been studied. To assess the role of m6A modifications during copper-induced oxidative stress responses, m6A-IP-seq was performed in Arabidopsis seedlings exposed to high levels of copper sulfate. This analysis revealed large-scale shifts in this modification on the transcripts most relevant for oxidative stress. This altered epitranscriptomic mark is known to influence transcript abundance and translation; therefore we scrutinized these possibilities. We found an increased abundance of copper-enriched m6A-containing transcripts. Similarly, we also found increased ribosome occupancy of copper-enriched m6A-containing transcripts, specifically those encoding proteins involved with stress responses relevant to oxidative stressors. Furthermore, the significance of the m6A epitranscriptome on plant oxidative stress tolerance was uncovered by assessing germination and seedling development of the mta (N6-methyladenosine RNA methyltransferase A mutant complemented with ABI3:MTA) mutant exposed to high copper treatment. These analyses suggested hypersensitivity of the mta mutant compared to the wild-type plants in response to copper-induced oxidative stress. Overall, our findings suggest an important role for m6A in the oxidative stress response of Arabidopsis.
Mango Consumption Was Associated with Higher Nutrient Intake and Diet Quality in Women of Childbearing Age and Older Adults
Authors: Fulgoni Kristin , Fulgoni Victor L.
Published: January 2024

Nutritional equity has been recognized as a priority in nutrition research, as reiterated by the new life-stage approach utilized by the Dietary Guidelines for Americans. Two of the life stages focused on are pregnant and lactating females as well as older adults, due to their unique nutritional needs and unique chronic health conditions. Both groups have low intakes of several nutrients, including those of public health concern, and suboptimal diet quality, underlining the importance to improve their dietary intakes. Incorporating fruit into their diets could help alleviate these gaps. Thus, the objective of the current study is to expand upon our current knowledge of the benefits of fruit within these two subgroups that DGA guidelines focus on and determine nutrient and food group intake as well as diet quality in women of childbearing age (WCA; as a proxy for pregnant and/or lactating females, n = 16,774) and older adult (n = 18,784) mango consumers compared with non-consumers, using NHANES 1988–1994 and 1999–2018. Both WCA and older adult mango consumers had greater than 20% higher intakes of fiber and vitamin C and WCA consumers had upwards of 10% higher folate, magnesium, and potassium intakes compared with non-consumers. Both groups of consumers had lower intake of saturated fat and older adults had lower intakes of protein and vitamin B12. Diet quality was 16 and 13% higher in WCA and older adult consumers compared with non-consumers, respectively. Additionally, mango consumers had lower beef, poultry, fish, and solid fat intakes and WCA consumers had higher whole grain intakes compared with non-consumers. This study suggests incorporating mango into the diet could increase select nutrient intake as well as diet quality in specific life stages of adult Americans.
Evaluation of the Immunosafety of Cucurbit[n]uril In Vivo
Authors: Pashkina Ekaterina , Aktanova Alina , Boeva Olga , Bykova Maria , Gavrilova Elena , Goiman Elena , Kovalenko Ekaterina , Saleh Na’il , Grishina Lyubov , Kozlov Vladimir
Published: January 2024

Cucurbiturils are a family of macrocyclic oligomers capable of forming host–guest complexes with various molecules. Due to noncovalent binding to drug molecules and low toxicity, cucurbiturils has been extensively investigated as potential carriers for drug delivery. However, the immune system’s interactions with different drug carriers, including cucurbiturils, are still under investigation. In this study, we focused on cucurbiturils’ immunosafety and immunomodulation properties in vivo. We measured blood counts and lymphocyte subpopulations in blood, spleen, and bone marrow, and assessed the in vivo toxicity to spleen and bone marrow cells after intraperitoneal administration to BALB/c mice. When assessing the effect of cucurbit[6]uril on blood parameters after three intraperitoneal injections within a week in laboratory animals, a decrease in white blood cells was found in mice after injections of cucurbit[6]util, but the observed decrease in the number of white blood cells was within the normal range. At the same time, cucurbit[7]uril and cucurbit[8]uril did not affect the leukocyte counts of mice after three injections. Changes in the number of platelets, erythrocytes, and monocytes, as well as in several other indicators, such as hematocrit or erythrocyte volumetric dispersion, were not detected. We show that cucurbiturils do not have immunotoxicity in vivo, with the exception of a cytotoxic effect on spleen cells after сucurbit[7]uril administration at a high dosage. We also evaluated the effect of cucurbiturils on cellular and humoral immune responses. We founded that cucurbiturils in high concentrations affect the immune system in vivo, and the action of various cucurbiturils differs in different homologues, which is apparently associated with different interactions in the internal environment of the body.
Engineered AAV2.7m8 Serotype Shows Significantly Higher Transduction Efficiency of ARPE-19 and HEK293 Cell Lines Compared to AAV5, AAV8 and AAV9 Serotypes
Authors: Gurtsieva Dzerassa , Minskaia Ekaterina , Zhuravleva Sofia , Subcheva Elena , Sakhibgaraeva Elena , Brovin Andrew , Tumaev Artem , Karabelsky Alexander
Published: January 2024

The level of transduction efficiency of the target retinal cells affects the choice of AAV serotype and the outcome of gene replacement therapy for inherited retinal diseases. This study focused on the tropism and transduction efficiency of AAV2.7m8-, AAV5-, AAV8-, and AAV9-GFP in ARPE-19 and HEK293 cells. Fluorescence intensity was assessed bi-hourly by means of IncuCyte S3 live imaging microscopy. Within 12 h, AAV2.7m8 demonstrated the highest transduction efficiency at four viral concentrations of 1-, 3-, 6-, and 8 × 104 VG/cell in a dose-dependent manner, followed by AAV5 in ARPE-19 and AAV9 in HEK293 cells. The transduction efficiency of AAV2.7m8 at a dose of 6 × 104 VG/cell was 21, 202, and 323 times higher in ARPE-19 cells and 324, 100, and 52 times higher in HEK293 cells compared to AAV5, AAV8, and AAV9, respectively. This trend remained for 4 days at all viral concentrations, as additionally shown by flow cytometry. At a dose of 6 × 104 VG/cell, AAV2.7m8 (97% GFP-positive cells, GFP +) was nearly two and 10 times as efficient as AAV5 (52% GFP+) and AAV9 or AAV8 (both 9%), respectively, in ARPE-19 cells. In HEK293 cells, 95% of AAV2.7m8-, 26% of AAV9-, 17% of AAV8-, and 12% of AAV5-transduced cells were GFP-positive.
Time-Delay Signature Suppression and Communications of Nanolaser Based on Phase Conjugate Feedback
Authors: Chen Hao , Mu Penghua , Guo Gang , Liu Xintian , He Pengfei
Published: January 2024

The nonlinear dynamics of nanolasers (NLs), an important component of optical sources, has received much attention. However, there is a lack of in-depth research into the high-quality chaotic output of NLs and their applications in chaotic secure communications. In this paper, we make the NLs generate broadband chaotic signals whose time-delay signatures (TDS) are completely hidden by a phase conjugate feedback structure. And in the two-channel communication scheme, we make the NLs achieve a combination of a low-latency high degree of synchronization and two-channel transmission technique, which enhances the security of message encryption and decryption. We also investigate the effects of system parameters, Purcell factor F, spontaneous emission coupling factor β, and bias current I on the TDS, as well as the effects of parameter mismatch and injection parameters on chaos synchronization and message recovery. The results show that the phase conjugate feedback-based NLs can achieve the suppression of the TDS within a certain parameter range, and it can achieve high-quality synchronization and enhance the security of chaotic communication under appropriate injection conditions.
Analysis of High-Order Surface Gratings Based on Micron Lasers on Silicon
Authors: Tian Jiachen , Chen Licheng , Zhou Xuliang , Yu Hongyan , Zhang Yejin , Pan Jiaoqing
Published: January 2024

High-quality silicon-based lasers are necessary to achieve full integration of photonic and electronic circuits. Monolithic integration of III–Vmicron lasers on silicon by means of the aspect ratio trapping (ART) method is a promising solution. To obtain sufficient optical feedback to excite the laser without introducing complex fabricating processes, we have designed a high-order surface grating on micron lasers which was epitaxially grown by the ART method and can be fabricated by common UV lithography. The performance of the grating was analyzed by the finite-difference time-domain (FDTD) method and eigenmode expansion (EME) solver. After simulation optimization, the etching depth was set to 0.6 μm to obtain proper reflection. The width of the slots and the slot spacing were selected to be 1.12 μm and 5.59 μm, respectively. Finally, we obtained results of 4% reflectance and 82% transmittance at a 1.55 μm wavelength at 24 periods.
The Toughness-Enhanced Atelocollagen Double-Network Gel for Biomaterials
Authors: Tsuyukubo Atsushi , Kubota Riku , Sato Yuzo , Fujimoto Ichiro
Published: January 2024

A tough gel composed of atelocollagen, which lacks an immunogenetic site, is a promising material for biomedical application. In this study, we created a composite hydrogel composed of atelocollagen gel cross-linked with glutaraldehyde (GA) and poly-(N,N-dimethylacrylamide) gel exhibiting biocompatibility based on the double-network (DN) gel principle. The tensile toughness of atelocollagen gel remained constant regardless of the amount of cross-linker (GA) used. In contrast, tensile tests of the DN gel indicated that mechanical properties, such as fracture stress and toughness, were significantly higher than those of the atelocollagen gel. Moreover, fibroblast cells adhered and spread on the gels, the Schiff bases of which were treated via reductive amination for detoxification from GA. These findings demonstrate the potential of the proposed gel materials as artificial alternative materials to soft tissues with sub-MPa fracture stress.
Tomographic Universality of the Discrete Wigner Function
Authors: Sainz Isabel , Camacho Ernesto , García Andrés , Klimov Andrei B.
Published: January 2024

We observe that the discrete Wigner functions (DWFs) of n-partite systems with odd local dimensions are tomographically universal, as reflected in the delta function form of the DWF for any stabilizer. However, in the n-qubit case, this property does not hold due to the non-factorization of the mapping kernel, the explicit form of which depends on a particular partition of the discrete phase space. Nonetheless, it turns out that the DWF for some specific stabilizers, not included in the set used for the construction of the Wigner map, takes on the form of a delta function. This implies that the possibility of classical simulations of Pauli measurements in a given stabilizer state for qubit systems is closely tied to the experimental setup.
Developing Encounters between Chinese and Western Art: The Contribution of Two Jesuits in China in the Seventeenth and Eighteenth Centuries
Authors: Feng Lisi
Published: January 2024

This article explores the introduction and influence of Western art in China during the Ming and Qing dynasties, focusing on the role of the Jesuits—especially Matteo Ricci (1552–1610), one of the founders of Catholic missionary work in China—and the most famous and influential Western figure in China’s art history, Giuseppe Castiglione (1688–1766). The Jesuits recognized art’s potential in their missionary efforts. The article examines the varied responses of Chinese literati to Western art theories in the 17th and 18th centuries, and how Jesuit-introduced artistic concepts were assimilated within different Chinese contexts. It also investigates how Western art merged into Chinese culture, noting the linguistic integration of concepts like chiaroscuro. In Ricci’s time, Western art intrigued the Chinese, but deep acceptance and conceptual transformation were limited. The assimilation of Western techniques was not as widespread as expected. In the 18th century, due to restrictions on Christianity, the religious role of painting diminished. Castiglione’s hybrid style, though influential in the Qing court, faced challenges in gaining cultural acceptance from the Han literati, leading to more criticism than in Ricci’s era. Despite these challenges and varying receptions, the contributions of Ricci and Castiglione to the Sino–Western art exchange are significant, reflecting the complex interplay of art, religion, and cultural dynamics across these periods.
Estimation of Economic Spillover Effects under the Hierarchical Structure of Urban Agglomeration Based on Time-Series Night-Time Lights: A Case Study of the Pearl River Delta, China
Authors: Bao Han , Tao Haiyan , Zhuo Li , Shi Qingli , Guo Siying
Published: January 2024

Urban agglomerations are becoming increasingly important in driving economic development in China. Accurate representation of the economic development status and spillover effects of cities within an urban agglomeration is the foundation of and an effective approach for promoting the coordinated development of that agglomeration. However, current studies of economic spillovers tend to focus on urban agglomerations as a whole, and there is a lack of scrutiny and validation of research data. Therefore, this study proposes a framework for detecting economic spillover effects within an urban agglomeration based on a prolonged night-time light dataset. Firstly, we explored the most suitable night-time light index to characterize the economic status. Then, we used this index to construct the economic network and hierarchical structure of the urban agglomeration. Finally, we explored the heterogeneity of spillover effects under the hierarchical structure. The results of a case study in the Pearl River Delta (PRD) urban agglomeration show that (1) the total night-time light in built-up areas (BNTL) has the highest Pearson correlation coefficient with GDP, which is 0.82; (2) there is an obvious hierarchical structure within the PRD; (3) there are significant and sustained economic spillover effects among the core cities, with Guangzhou–Foshan and Shenzhen–Dongguan having more obvious spillover effects; and (4) the economic spillover effects within the three metropolitan areas have different characteristics. The Guangzhou–Foshan–Zhaoqing metropolitan area is closely linked, to apparent differences in the pace of spillover effects. The Shenzhen–Dongguan–Huizhou metropolitan area has strong close linkages, with strong synchronization of spillover effects. The Zhuhai–Zhongshan–Jiangmen metropolitan area has not yet formed a stable synergistic development relationship. Overall, the framework can effectively reveal the hierarchical structure and different characteristics of economic spillovers within urban agglomerations, which can provide a scientific reference for policy making related to the coordinated development of such agglomerations.
Intercomparison of Landsat Operational Land Imager and Terra Advanced Spaceborne Thermal Emission and Reflection Radiometer Radiometric Calibrations Using Radiometric Calibration Network Data
Authors: Yarahmadi Mehran , Thome Kurtis , Wenny Brian N. , Czapla-Myers Jeff , Voskanian Norvik , Tahersima Mohammad , Eftekharzadeh Sarah
Published: January 2024

This paper presents a comprehensive intercomparison study investigating the radiometric performance of and concurrence among the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), Landsat 8 Operational Land Imager (L8 OLI), and Landsat 9 OLI (L9 OLI) instruments. This study leverages data sourced from the Radiometric Calibration Network (RadCalNet) and focuses on spectral bands relevant for vegetation analysis and land cover classification, encompassing a thorough assessment of data quality, uncertainties, and underlying influencing factors. This study’s outcomes underscore the efficacy of RadCalNet in evaluating the precision and reliability of remote sensing data, offering valuable insights into the strengths and limitations of ASTER, L8 OLI, and L9 OLI. These insights serve as a foundation for informed decision making in environmental monitoring and resource management, highlighting the pivotal role of RadCalNet in gauging the radiometric performance of remote sensing sensors. Results from RadCalNet sites, namely Railroad Valley Playa and Gobabeb, show their possible suitability for sensors with spatial resolutions down to 15 m. The results indicate that the measurements from both ASTER and OLI closely align with the data from RadCalNet, and the observed agreement falls comfortably within the total range of potential errors associated with the sensors and the test site information.
Pressure Sensors: Working Principles of Static and Dynamic Calibration
Authors: Pereira José Dias
Published: January 2024

This paper starts with an overview of the main principles used for pressure measurements, focusing on their usage in industrial applications’ domains. Then, the importance of calibration procedures, namely, static and dynamic calibration of pressure sensors, is analyzed. Regarding calibration, it is important to note that there are several applications where the pressure signals to be measured can have large variations in short periods of time. In industrial applications, particularly in continuous production processes, generally, dynamic pressure measurements are less common; however, they are still required in several cases, such as control loops that are very sensitive to pressure variations, even if the frequencies of those variations are in the range of a few tens of hertz, or even lower. The last part of the paper presents the hardware and software of a flexible and low-cost static and dynamic pressure calibrator that also presents the capability to generate arbitrary waveform pressure signals for calibration and testing purposes. The proposed calibrator also includes the following advantages: remote pressure sensing capabilities that can be used to minimize calibration errors, such as those associated with capillary effects and pressure leakages; portability; and low cost. The paper ends with some experimental results obtained with the proposed calibrator.
Assessment of Directional–Hemispherical Reflectance of Tablets with Cefuroxime during Storage under Elevated Temperature and Ultraviolet Radiation
Authors: Meisner Michał , Sarecka-Hujar Beata
Published: January 2024

Environmental conditions can lead to changes in the physical and chemical structures of drug products. In this study, the stability of cefuroxime tablets stored under adverse conditions was evaluated based on total directional–hemispherical reflectance (THR). The THR value was measured before and after the tablets’ exposure to stress factors (temperature of 45 °C and UV radiation). Each measurement was performed three times within seven spectral bands at the beginning of the experiment (day 0), and then on days 1, 2, 3, 5, and 7. In addition, hyperspectral profiles (400–1030 nm) were analyzed on days 0 and 7. A significant decrease in THR values in all wavelength ranges was observed when day 7 vs. day 0 were compared, especially for spectral bands of 335–380 nm and 1700–2500 nm (Δ = 0.220, p < 0.001 and Δ = 0.171, p < 0.001, respectively). The hyperspectral analysis confirmed a decrease in the reflectance after the end of stress conditions in the visible light range (400–700 nm) compared to tablets before the experiment. This may indicate that more radiation entered the tablets. In conclusion, the THR of cefuroxime tablets decreases during the exposure to heat and UV radiation, which may result from some physicochemical changes that have occurred during storage.
Low-Energy Ion Implantation and Deep-Mesa Si-Avalanche Photodiodes with Improved Fabrication Process
Authors: Wang Tiancai , Peng Hongling , Cao Peng , Zhuang Qiandong , Deng Jie , Chen Jian , Zheng Wanhua
Published: January 2024

Since the avalanche phenomenon was first found in bulk materials, avalanche photodiodes (APDs) have been exclusively investigated. Among the many devices that have been developed, silicon APDs stand out because of their low cost, performance stability, and compatibility with CMOS. However, the increasing industrial needs pose challenges for the fabrication cycle time and fabrication cost. In this work, we proposed an improved fabrication process for ultra-deep mesa-structured silicon APDs for photodetection in the visible and near-infrared wavelengths with improved performance and reduced costs. The improved process reduced the complexity through significantly reduced photolithography steps, e.g., half of the steps of the existing process. Additionally, single ion implantation was performed under low energy (lower than 30 keV) to further reduce the fabrication costs. Based on the improved ultra-concise process, a deep-mesa silicon APD with a 140 V breakdown voltage was obtained. The device exhibited a low capacitance of 500 fF, the measured rise time was 2.7 ns, and the reverse bias voltage was 55 V. Moreover, a high responsivity of 103 A/W@870 nm at 120 V was achieved, as well as a low dark current of 1 nA at punch-through voltage and a maximum gain exceeding 1000.
Designing and Testing an IoT Low-Cost PPP-RTK Augmented GNSS Location Device
Authors: Amalfitano Domenico , Cutugno Matteo , Robustelli Umberto , Pugliano Giovanni
Published: January 2024

Nowadays, the availability of affordable multi-constellation multi-frequency receivers has broadened access to accurate positioning. The abundance of satellite signals coupled with the implementation of ground- and satellite-based correction services has unlocked the potential for achieving real-time centimetre-level positioning with low-cost instrumentation. Most of the current and future applications cannot exploit well-consolidated satellite positioning techniques such as Network Real Time Kinematic (RTK) and Precise Point Positioning (PPP); the former is inapplicable for large user bases due to the necessity of a two-way communication link between the user and the NRTK service provider, while the latter necessitates long convergence times that are not in keeping with kinematic application. In this context, the hybrid PPP-RTK technique has emerged as a potential solution to meet the demand for real-time, low-cost, accurate, and precise positioning. This paper presents an Internet of Things (IoT) GNSS device developed with low-cost hardware; it leverages a commercial PPP-RTK correction service which delivers corrections via IP. The main target is to obtain both horizontal and vertical decimetre-level accuracies in urban kinematic tests, along with other requisites such as solution availability and the provision of connection ports for interfacing an IoT network. A vehicle-borne kinematic test has been conducted to evaluate the device performance. The results show that (i) the IoT device can deliver horizontal and vertical positioning solutions at decimetre-level accuracy with the targeted solution availability, and (ii) the provided IoT ports are feasible for gathering the position solutions over an internet connection.
How Not to Make the Joint Extended Kalman Filter Fail with Unstructured Mechanistic Models
Authors: Iglesias Cristovão Freitas , Bolic Miodrag
Published: January 2024

The unstructured mechanistic model (UMM) allows for modeling the macro-scale of a phenomenon without known mechanisms. This is extremely useful in biomanufacturing because using the UMM for the joint estimation of states and parameters with an extended Kalman filter (JEKF) can enable the real-time monitoring of bioprocesses with unknown mechanisms. However, the UMM commonly used in biomanufacturing contains ordinary differential equations (ODEs) with unshared parameters, weak variables, and weak terms. When such a UMM is coupled with an initial state error covariance matrix P(t=0) and a process error covariance matrix Q with uncorrelated elements, along with just one measured state variable, the joint extended Kalman filter (JEKF) fails to estimate the unshared parameters and state simultaneously. This is because the Kalman gain corresponding to the unshared parameter remains constant and equal to zero. In this work, we formally describe this failure case, present the proof of JEKF failure, and propose an approach called SANTO to side-step this failure case. The SANTO approach consists of adding a quantity to the state error covariance between the measured state variable and unshared parameter in the initial P(t = 0) of the matrix Ricatti differential equation to compute the predicted error covariance matrix of the state and prevent the Kalman gain from being zero. Our empirical evaluations using synthetic and real datasets reveal significant improvements: SANTO achieved a reduction in root-mean-square percentage error (RMSPE) of up to approximately 17% compared to the classical JEKF, indicating a substantial enhancement in estimation accuracy.
Urban Traffic Congestion Prediction: A Multi-Step Approach Utilizing Sensor Data and Weather Information
Authors: Tsalikidis Nikolaos , Mystakidis Aristeidis , Koukaras Paraskevas , Ivaškevičius Marius , Morkūnaitė Lina , Ioannidis Dimosthenis , Fokaides Paris A. , Tjortjis Christos , Tzovaras Dimitrios
Published: January 2024

The continuous growth of urban populations has led to the persistent problem of traffic congestion, which imposes adverse effects on quality of life, such as commute times, road safety, and the local air quality. Advancements in Internet of Things (IoT) sensor technology have contributed to a plethora of new data streams regarding traffic conditions. Therefore, the recognition and prediction of traffic congestion patterns utilizing such data have become crucial. To that end, the integration of Machine Learning (ML) algorithms can further enhance Intelligent Transportation Systems (ITS), contributing to the smart management of transportation systems and effectively tackling traffic congestion in cities. This study seeks to assess a wide range of models as potential solutions for an ML-based multi-step forecasting approach intended to improve traffic congestion prediction, particularly in areas with limited historical data. Various interpretable predictive algorithms, suitable for handling the complexity and spatiotemporal characteristics of urban traffic flow, were tested and eventually shortlisted based on their predictive performance. The forecasting approach selects the optimal model in each step to maximize the accuracy. The findings demonstrate that, in a 24 h step prediction, variating Ensemble Tree-Based (ETB) regressors like the Light Gradient Boosting Machine (LGBM) exhibit superior performances compared to traditional Deep Learning (DL) methods. Our work provides a valuable contribution to short-term traffic congestion predictions and can enable more efficient scheduling of daily urban transportation.
Efficient Decoder and Intermediate Domain for Semantic Segmentation in Adverse Conditions
Authors: Chen Xiaodong , Jiang Nan , Li Yifeng , Cheng Guangliang , Liang Zheng , Ying Zuobin , Zhang Qi , Zhao Runsheng
Published: January 2024

In smart city contexts, traditional methods for semantic segmentation are affected by adverse conditions, such as rain, fog, or darkness. One challenge is the limited availability of semantic segmentation datasets, specifically for autonomous driving in adverse conditions, and the high cost of labeling such datasets. To address this problem, unsupervised domain adaptation (UDA) is commonly employed. In UDA, the source domain contains data from good weather conditions, while the target domain contains data from adverse weather conditions. The Adverse Conditions Dataset with Correspondences (ACDC) provides reference images taken at different times but in the same location, which can serve as an intermediate domain, offering additional semantic information. In this study, we introduce a method that leverages both the intermediate domain and frequency information to improve semantic segmentation in smart city environments. Specifically, we extract the region with the largest difference in standard deviation and entropy values from the reference image as the intermediate domain. Secondly, we introduce the Fourier Exponential Decreasing Sampling (FEDS) algorithm to facilitate more reasonable learning of frequency domain information. Finally, we design an efficient decoder network that outperforms the DAFormer network by reducing network parameters by 28.00%. When compared to the DAFormer work, our proposed approach demonstrates significant performance improvements, increasing by 6.77%, 5.34%, 6.36%, and 5.93% in mean Intersection over Union (mIoU) for Cityscapes to ACDC night, foggy, rainy, and snowy, respectively.
Effectiveness of Non-Geotagged Social Media Data for Monitoring Visitor Experience in a National Park in Japan
Authors: Kubota Yutaka , Miyasaka Takafumi , Kajikawa Masahiro , Oba Akihiro , Miyasaka Katori
Published: January 2024

In the pursuit of sustainable national park management, park managers need to understand the interests and activities of their diverse visitors in order to conserve the natural environment and offer a better visitor experience. This study aimed to examine the effectiveness of using non-geotagged social media data from posts by park visitors for park management in comparison with geotagged data, which has been studied more extensively. We compared (1) visitors’ sociodemographic characteristics between geotagged and non-geotagged social media users through an onsite survey in Nikko National Park, Japan, and (2) the content of geotagged and non-geotagged photos shared within the study area on X (formerly Twitter). Our results showed that visitors in their 30s and 40s and foreign visitors had a greater tendency to use geotags. Non-geotagged photos more frequently and deeply capture nature-based activities and interests, including activities on trails, such as mountain climbing and hiking, and an interest in diverse animals and plants and landscapes that are less accessible. These findings indicate that non-geotagged social media data may have less age and nationality bias and advantages over the more widely-used geotagged data in capturing various nature-based experiences offered by national parks. Leveraging both geotagged and non-geotagged data can enable park managers to implement sustainable practices catering to a broader range of visitor interests and activities, contributing to the overarching goal of sustaining the natural environment while also enriching the visitor experience within national parks.