bluuebunny/crossref_metadata_2025 huggingface dataset:
Immediate Effects of Prescribed Fire on Sub-Surface Water Quality in a Managed Yellow Pine Forest
Authors: Klimas Kipling , Hiesl Patrick , Hagan Donald , Park Dara
Published: May 2020

Although prescribed fire is a forest management tool annually applied to nearly one million hectares across the southeastern United States, little is known about how prescribed fire influences soil water quality in the region. Sub-surface pools of nitrogen (N) and phosphorous (P) are important indicators of ecosystem response to disturbance and are likely modified, at least temporarily, by fire. We undertook a five-month study to examine sub-surface nutrient concentrations and pH in a managed yellow pine (Pinus sp.) forest before and after a low-severity dormant season prescribed fire in the Southern Blue Ridge Mountains of South Carolina. Between February and July 2019, soil solution was collected weekly from a 30 cm porous cup suction lysimeters and analyzed for ammonium (NH4+), nitrate (NO3-), and orthophosphate (PO43-), as well as pH. We compared the five-month mean and maximum nutrient concentrations and pH to quantify the immediate effects of prescribed fire. The prescribed fire caused significant pH buffering towards neutrality in burned transects relative to the control. There was no change in soil solution NO3-. The prescribed fire caused a significant increase in maximum NH4+ (18.0 mg/L) and PO43- (6.6 mg/L) concentrations. Post-fire NH4+ concentrations reached a maximum of 18.0 mg/L before declining three weeks post-fire. PO43- concentrations in burned stands reached a maximum of 6.6 mg/L and remained elevated for four weeks post-fire. Nutrient leaching was minimal due to complexion to soil cations and ground water uptake from regenerating vegetation at the onset of the growing season. The PO43- and NH4+ pulses in this study are likely influenced by fire-induced changes to soil chemistry and future studies should examine the homogeneity of pH buffering and nutrient pulses across the burned landscape.
The Heat Flux Vector(s) in a Two Component Fluid Mixture
Authors: Kirwan A. D. , Massoudi Mehrdad
Published: May 2020

Bulk kinematic properties of mixtures such as velocity are known to be the density weighed averages of the constituent velocities. No such paradigm exists for the heat flux of mixtures when the constituents have different temperatures. Using standard principles such as frame indifference, we address this topic by developing linear constitutive equations for the constituent heat fluxes, the interaction force between constituents, and the stresses for a mixture of two fluids. Although these equations contain 18 phenomenological coefficients, we are able to use the Clausius-Duhem inequality to obtain inequalities involving the principal and cross flux coefficients. The theory is applied to some special cases and shown to reduce to standard results when the constituents have the same temperature.
Revisiting the Dynamic Linkages of Treasury Bond Yields for the BRICS: A Forecasting Analysis
Authors: Bekiros Stelios , Avdoulas Christos
Published: May 2020

We examined the dynamic linkages among money market interest rates in the so-called “BRICS” countries (Brazil, Russia, India, China, and South Africa) by using weekly data of the overnight, one-, three-, and six- months, as well as of one year, Treasury bills rates covering the period from January 2005 to August 2019. A long-run relationship among interest rates was established by employing the Vector Error Correction modeling (VECM), which revealed the validation of the Expectation Hypothesis Theory (EH) of the term structure of interest rates, taking into account long-run deviations from equilibrium and inherent nonlinearities. We unveiled short-run dynamic adjustments for the term structure of the BRICS, subject to regime switches. We then used Markov Switching Vector Error Correction models (MS-VECM) to forecast them dynamically during an out-of-sample period of May 2016 through August 2019. The MSIH-VECM forecasts were found to be superior to the VECM approaches. The novelty of our paper is mainly due to the exploration of the possibility of parameter instability as a crucial factor, which might explain the rejection of the restricted version of the cointegration space, and on the dynamic out-of-sample forecasts of the term structure over a more recent time span in order to assess further the usefulness of our nonlinear MS-VECM characterization of the term structure, capturing the effects of the global and domestic financial crisis.
Inverse Correlation Between Grip Strength and Serum Phosphorus: A Retrospective Observational Study in Japanese Elderly with Poorly Controlled Type 2 Diabetes
Authors: Tanaka Sho , Takubo Masahiro , Kohno Genta , Kushimoto Masaru , Ikeda Jin , Ogawa Katsuhiko , Suzuki Yutaka , Abe Masanori , Ishihara Hisamitsu , Fujishiro Midori
Published: May 2020

The aim of this study was to investigate factors associated with sarcopenia among elderly patients with poorly controlled diabetes mellitus (DM). We retrospectively analyzed 41 patients with type 2 DM, aged ≥65 years who required diabetes education hospitalization. Patients were classified into two groups according to the presence or absence of a weakened hand grip, and clinical characteristics were compared. Patients with a weakened hand grip (n = 21) scored worse on a mini-mental state examination (24.3 vs. 26.5, p = 0.04), showed a higher prevalence of diabetic peripheral neuropathy (76% vs. 40%, p = 0.03), and had a higher serum phosphorus concentration (3.8 vs. 3.3 mg/dL, p < 0.01) compared to those without a weakened hand grip (n = 20). The serum phosphorus concentration was inversely correlated to hand grip strength (r = −0.501, p < 0.001) among the total of 41 patients. This inverse association was also confirmed after adjusting the effects of estimated glomerular filtration rate, age, and glycated hemoglobin. Thus, cognitive impairment, diabetic peripheral neuropathy, and high serum phosphorus concentrations are associated with hand grip weakness in elderly patients with type 2 DM.
Constructing Constraint-Based Simulation System for Creating Emergency Evacuation Plans: A Case of an Outpatient Chemotherapy Area at a Cancer Medical Center
Authors: Wu I-Chen , Lin Yi-Chun , Yien Huey-Wen , Shih Fuh-Yuan
Published: May 2020

Making emergency evacuation plans for disaster prevention is always a high priority for hospital administrators to ensure the safety of patients and employees. This study employs the outpatient chemotherapy area of a cancer medical center as an example, and its area involves professional medical care and relatively complex human group behaviors. Hence, it is necessary to simulate evacuations in advance to formulate a special evacuation plan. To achieve this task, a constraint-based simulation system is developed with three major processes: defining spatial and activity constraints, agent-based modeling, and optimizing resource allocation. The spatial boundaries are converted from a three-dimensional model in the Building Information Modeling (BIM) to conduct a visualized simulation. Based on the spatial boundaries, the activities of the agents are set to obey the process specified by work studies. Finally, the Monte Carlo method is employed to simulate the stochastic rescue behaviors of nurses during disasters to determine the fittest resource allocation with the shortest evacuation time for different numbers of patients. The results reveal that the proposed system can output a suggested list of resource allocations and visualized results for administrators when making evacuation plans such that all the people in the area can be safely evacuated.
Global Mapping of Research Trends on Interventions to Improve Health-Related Quality of Life in Asthma Patients
Authors: Phan Hai Thanh , Vu Giap Van , Vu Giang Thu , Ha Giang Hai , Pham Hai Quang , Latkin Carl A. , Tran Bach Xuan , Ho Cyrus S.H. , Ho Roger C.M.
Published: May 2020

Globally, approximately 335 million people are being affected by asthma. Given that asthma is a chronic airway condition that cannot be cured, the disease negatively impacts physical health and results in losses of productivity of people experiencing asthma, leading to decrease in quality of life. This study aims at demonstrating the research trends worldwide and identifying the research gaps in interventions for improving quality of life of patients with asthma. Bibliometric approach and content analysis, which can objectively evaluate the productivity and research landscapes in this field, were utilized. In this study, we systematically quantified the development of research landscapes associated with interventions for improving quality of life of people experiencing asthma. Along with the gradual growth in the number of publications, these research topics have relatively expanded in recent years. While the understanding of the pathophysiology, diagnosis and treatment of asthma has been well-established, recent research has showed high interest in the control and management of asthma. Findings of this study suggest the need for more empirical studies in developing countries and further investigation into the effects of environment factors on asthma outcomes, as well as the economic burden of asthma.
An Exploration of Motivation for Disaster Engagement and Its Related Factors among Undergraduate Nursing Students in Taiwan
Authors: Liou Shwu-Ru , Liu Hsiu-Chen , Lin Chun-Chih , Tsai Hsiu-Min , Cheng Ching-Yu
Published: May 2020

The purpose of the study was to explore the levels of and relationships between disaster nursing competence, anticipatory disaster stress, and the motivation for disaster engagement among undergraduate nursing students in Taiwan. A cross-sectional research design was applied. Using convenience sampling, 90 nursing students participated with an 86.54% response rate. The Disaster Core Competencies Questionnaire, Anticipatory Disaster Stress Questionnaire, and Motivation for Disaster Engagement Questionnaire were used to collect data. The Pearson correlation and ANOVA were used to analyze the data. Results showed that students’ level of disaster nursing competence was low, anticipatory disaster stress was not high, and motivation for disaster engagement was high. Motivation for disaster engagement was positively correlated with anticipatory disaster stress. Students who were more willing to participate in disaster management had a higher level of anticipatory disaster stress and motivation for disaster engagement. It is suggested that healthcare institutions and schools should work together to design disaster education plans using innovative teaching/learning strategies to increase students’ willingness and motivation for disaster engagement.
A Nested Ensemble Approach with ANNs to Investigate the Effect of Socioeconomic Attributes on Active Commuting of University Students
Authors: Assi Khaled , Gazder Uneb , Al-Sghan Ibrahim , Reza Imran , Almubarak Abdullah
Published: May 2020

Analysis of travel mode choice is vital in policymaking and transportation planning to comprehend and forecast travel demands. Universities resemble major trip attraction hubs, with many students and faculty members living on campus or nearby. This study aims to investigate the effects of socioeconomic characteristics on the travel mode choice of university students. A nested ensemble approach with artificial neural networks (ANNs) was used to model the mode choice behavior. It was found that students generally prefer motorized modes (bus and car). A more detailed analysis revealed that teenage students (aged 17–19 years) had an approximately equal probability of selecting motorized and non-motorized modes. Graduate students revealed a higher tendency to select motorized modes compared with other students. The findings of this study demonstrate the need to promote non-motorized modes of transport among students, which is possible by providing favorable infrastructure for these modes.
Low-Value Clinical Practices: Knowledge and Beliefs of Spanish Surgeons and Anesthetists
Authors: Aranaz Andrés Jesús , Valencia-Martín José , Vicente-Guijarro Jorge , Díaz-Agero Pérez Cristina , López-Fresneña Nieves , Carrillo Irene , Mira Solves José ,   SOBRINA Working Group
Published: May 2020

OBJECTIVES: To know the frequency and causes of low value surgical practices, according to the opinion of surgeons and anesthetists, and to determine their degree of knowledge about the Spanish “Choosing wisely” initiative. METHODS: Cross-sectional observational study, based on a self-administered online questionnaire through an opportunistic sample of 370 surgeons and anesthetists from three Spanish regions, contacted through Scientific Societies. The survey took part between July and December 2017. RESULTS: A patient profile requesting unnecessary practices was identified (female, 51−65 years old and unaffiliated disease). The frequency of requests was weekly or daily for 50.0% of the professionals, of whom 15.1% acknowledged succumbing to these pressures. To dissuade the patient, clinical reasons (47%) were considered the most effective. To increase control and safety in the case was the main reason to indicate them. The greatest responsibility for overuse was attributed to physicians, defensive medicine and mass media. Assessing professionals’ knowledge on unnecessary practices, an average of 5 correct answers out of 7 was obtained. Some 64.1% of the respondents were unaware of the Spanish “Choosing wisely” initiative. CONCLUSIONS: Low value surgical practices are perceived as a frequent problem, which requires an approach entailing intervention with patients and the media as well as professionals. Increase awareness on unnecessary surgical practices, and how to avoid them remain essential.
Exploring Changes in Activity Patterns in Individuals with Chronic Pain
Authors: Serrano-Ibáñez Elena Rocío , Bendayan Rebecca , Ramírez-Maestre Carmen , López-Martínez Alicia Eva , Ruíz-Párraga Gema Teresa , Peters Madelon , Esteve Rosa
Published: May 2020

This longitudinal study explored whether activity patterns change over time in a sample of 56 individuals with chronic musculoskeletal pain over a 15-day period. Once a day, the participants recorded their level of pain intensity and the degree to which they had engaged in several specific activity patterns. Linear mixed models with random coefficients were used to investigate the rate of change in the activity patterns. Age, sex, pain intensity, and pain duration were controlled. The results show that excessive persistence was the only self-reported activity pattern to show a linear change over the 15-day period. There was a decrease in excessive persistence, and this decrease was slower with higher levels of activity avoidance. However, no significant association was found between sex, age, pain intensity, and pain duration and excessive persistence at baseline or change over time. At baseline, a positive association was found between excessive persistence and pain avoidance, pain-related persistence, and pacing to reduce pain, and a negative association was found between excessive persistence and pacing to save energy for valued activities. This result suggests a profile characterized by alternate periods of high and low activity that, in this study, were unrelated to longitudinal changes in pain intensity.
Spatial Variation Characteristics of Soil Erodibility in the Yingwugou Watershed of the Middle Dan River, China
Authors: Liu Xiaojun , Zhang Yi , Li Peng
Published: May 2020

Knowledge of soil erodibility (k-value) is vital for measuring soil erosion and conservation planning. Through field sampling, laboratory analysis, and geostatistical analysis, the effects of land use type and soil depth on soil erodibility were studied in a typical watershed of China. The spatial distribution of k-value was determined by Kriging interpolation. Results showed that: (1) soil organic carbon (SOC) content in the study aera is 0.09–150.00 g/kg, and the soil is dominated by silt. The soil erodibility k-values obeyed normal distribution, with an average value of 0.032 t·hm2·h/(MJ·mm·hm2) and a medium degree variation. (2) k-values increased with soil depth. The k-values of surface soil (0–10 cm) for the six different vegetation types ranked in the following order: oak forest > peanut field > grassland > pine forest > tea field > corn field. (3) The theoretical semivariogram model of k-values was a spherical model; k-values in the study area gradually decreased from south to north and east to west, with an obvious banding distribution. Human activities have the greatest effect on k-value such that specific corresponding managements are needed. This could provide scientific and technological support for soil and water conservation measures and comprehensive utilization of the resources.
What Is Accounting for the Rapid Decline in Cigarette Sales in Japan?
Authors: Cummings K. Michael , Nahhas Georges J. , Sweanor David T.
Published: May 2020

This study describes how trends in the sale of cigarettes in Japan between 2011 and 2019 correspond to the sales of heated tobacco products (HTPs) that were introduced into the Japanese market in late 2015. Data used for this study come from the Tobacco Institute of Japan and Philip Morris International. The findings show that the accelerated decline in cigarette only sales in Japan since 2016 corresponds to the introduction and growth in the sales of HTPs.
Sedentary Behavior Research in the Chinese Population: A Systematic Scoping Review
Authors: Bao Ran , Chen Si-Tong , Wang Yanlei , Xu Jun , Wang Lei , Zou Liye , Cai Yujun
Published: May 2020

Background: The negative effects of sedentary behavior (SB) on public health have been extensively documented. A large number of studies have demonstrated that high prevalence of SB is a critical factor of all-cause mortality. Globally, the frequency of SB research has continued to rise, but little is known about SB in the Chinese population. Therefore, this review was conducted to scope the research situation and to fill the gaps related to the effects of SB in the Chinese population. Methods: Using a scoping review based on York methodology, a comprehensive search of published journal articles and grey literature was carried out through 12 databases. The literature research was conducted by two authors in July 2019, and included journal articles that targeted on the Chinese population were published between 1999 and 2019. The two authors screened the records independently and included those research topics related to SB in the Chinese population. Results: The number of included studies increased from 1 to 29 per year during the analyzed period, during which, a remarkable climb happened from 8 in 2013 to 19 in July 2019. Out of the 1303 screened studies, a total of 162 studies (81 English and 81 Chinese journal articles) met the inclusion criteria in this review. Most of the included studies (66.0%) reported the overall estimated prevalence of SB, in which, 43.2% of studies reported the average time of SB, and 40.0% of studies reported the cutoff point of SB. Besides this, 54.9% and 23.5% of studies focused on the outcomes and correlates/determinants of SB, and the proportions of studies based on testing the validation of measurement tools and on interventions were 3.7% and 4.9%, respectively. Nearly all of the reviewed articles used data from cross-sectional studies (75.9%) and longitudinal studies (13.6%), while intervention trials are less developed. The majority of the studies (64.8%) used self-reported surveys, and only 3.7% studies used device-based measurement tools. Furthermore, 35.8% of the included studies were focused on children and adolescents, while only a few studies investigated infants/toddlers and older adults. Both female and male were examined in most studies, and non-clinical populations were investigated in the context of SB in a relatively large number of studies. Conclusions: The number of research articles on SB in the Chinese population published per year has increased year by year, indicating a growing interest in this research area. More studies using population subgroup samples are needed, particularly among infants/toddlers, older adults, and clinical populations. To provide stronger evidence of the determinants and outcomes of SB, longitudinal studies using device-based measures of SB are required.
Effect of HIIT with Tabata Protocol on Serum Irisin, Physical Performance, and Body Composition in Men
Authors: Murawska-Cialowicz Eugenia , Wolanski Pawel , Zuwala-Jagiello Jolanta , Feito Yuri , Petr Miroslav , Kokstejn Jakub , Stastny Petr , Goliński Dawid
Published: May 2020

High-intensity interval training (HIIT) is frequently utilized as a method to reduce body mass. Its intensity of work results in a number of beneficial adaptive changes in a relatively short period of time. Irisin is a myokine and adipokine secreted to the blood during exercise and it takes part in the regulation of energy metabolism. It is a vital issue from the prophylaxis point of view as well as treatment through exercise of different diseases (e.g., obesity, type-2 diabetes). The aim of this study was to evaluate changes in irisin concentration, body composition, and aerobic and anaerobic performance in men after HIIT. Eight weeks of HIIT following the Tabata protocol was applied in the training group (HT) (n = 15), while a sedentary group (SED) (n = 10) did not participate in fitness activities within the same time period. Changes of irisin, body composition, and aerobic and anaerobic performance were evaluated after graded exercise test (GXT) and Wingate anaerobic test (WAnT) before and after eight weeks of training. Training resulted in an increased of blood irisin concentration (by 29.7%) p < 0.05), VO2max increase (PRE: 44.86 ± 5.74 mL·kg−1·min−1; POST: 50.16 ± 5.80 mL kg−1·min−1; p < 0.05), reduction in percent body fat (PRE: 14.44 ± 3.33%; POST: 13.61 ± 3.16%; p < 0.05), and increase of WAnT parameters (p < 0.05) in the HT group. No changes were observed in the SED group. HIIT resulted in beneficial effects in the increase in blood irisin concentration, physical performance, and reduced fat content. The HIIT may indicate an acceleration of base metabolism. This effect can be utilized in the prevention or treatment of obesity.
Mechanized and Optimized Configuration Pattern of Crop-Mulberry Systems for Controlling Agricultural Non-Point Source Pollution on Sloping Farmland in the Three Gorges Reservoir Area, China
Authors: Zhong Shouqin , Han Zhen , Li Jiangwen , Xie Deti , Yang Qingyuan , Ni Jiupai
Published: May 2020

High-intensity utilization of sloping farmland causes serious soil erosion and agricultural non-point source pollution (AGNSP) in the Three Gorges Reservoir Area (TGRA). Crop-mulberry systems are important agroforestry systems for controlling soil, water, and nutrient losses. However, there are many different mulberry hedgerow planting patterns in the TGRA. In this study, soil structure, nutrient buildup, and runoff nutrient loss were observed in field runoff plots with five configurations: P1 (two longitudinal mulberry hedgerows), P2 (two mulberry contour hedgerows), P3 (three mulberry contour hedgerows), P4 (mulberry hedgerow border), and P5 (mulberry hedgerow border and one mulberry contour hedgerow), as well as a control (CT; no mulberry hedgerows). P1 had the smallest percentage of aggregate destruction (18.8%) and largest mean weight diameter (4.48 mm). P5 led to the greatest accumulation of ammonium nitrogen (NH4+–N) and total phosphorus (TP) (13.4 kg ha−1 and 1444.5 kg ha−1 on average, respectively), while P4 led to the greatest accumulation of available phosphorus (AP), nitrate nitrogen (NO3−–N), and total nitrogen (TN) (114.0, 14.9, and 1694.1 kg ha−1, respectively). P5 was best at preventing soil erosion, with the smallest average annual runoff and sediment loss of 112.2 m3 ha−1 and 0.06 t ha−1, respectively, which were over 72.4% and 87.4% lower than those in CT, respectively. P5 and P4 intercepted the most N in runoff, with average NH4+–N, NO3−–N, particulate N, and TN losses of approximately 0.09, 0.07, 0.41, and 0.58 kg ha−1, respectively, which were 49.7%, 76.2%, 71.3%, and 69.9% lower than those in CT, respectively. P5 intercepted the most P in runoff, with average TP and total dissolved phosphorus (TDP) losses of 0.09 and 0.04 kg ha−1, respectively, which were 77.5% and 70.4% lower than those in CT, respectively. Therefore, the pattern with one mulberry hedgerow border and one mulberry contour hedgerow (P5) best controlled AGNSP, followed by that with only a mulberry hedgerow border (P4).
Automated Conflation of Digital Elevation Model with Reference Hydrographic Lines
Authors: Samsonov Timofey E.
Published: May 2020

Combining misaligned spatial data from different sources complicates spatial analysis and creation of maps. Conflation is a process that solves the misalignment problem through spatial adjustment or attribute transfer between similar features in two datasets. Even though a combination of digital elevation model (DEM) and vector hydrographic lines is a common practice in spatial analysis and mapping, no method for automated conflation between these spatial data types has been developed so far. The problem of DEM and hydrography misalignment arises not only in map compilation, but also during the production of generalized datasets. There is a lack of automated solutions which can ensure that the drainage network represented in the surface of generalized DEM is spatially adjusted with independently generalized vector hydrography. We propose a new method that performs the conflation of DEM with linear hydrographic data and is embeddable into DEM generalization process. Given a set of reference hydrographic lines, our method automatically recognizes the most similar paths on DEM surface called counterpart streams. The elevation data extracted from DEM is then rubbersheeted locally using the links between counterpart streams and reference lines, and the conflated DEM is reconstructed from the rubbersheeted elevation data. The algorithm developed for extraction of counterpart streams ensures that the resulting set of lines comprises the network similar to the network of ordered reference lines. We also show how our approach can be seamlessly integrated into a TIN-based structural DEM generalization process with spatial adjustment to pre-generalized hydrographic lines as additional requirement. The combination of the GEBCO_2019 DEM and the Natural Earth 10M vector dataset is used to illustrate the effectiveness of DEM conflation both in map compilation and map generalization workflows. Resulting maps are geographically correct and are aesthetically more pleasing in comparison to a straightforward combination of misaligned DEM and hydrographic lines without conflation.
Comparative Transcriptome Analysis of Two Aegilops tauschii with Contrasting Drought Tolerance by RNA-Seq
Authors: Zhao Xinpeng , Bai Shenglong , Li Lechen , Han Xue , Li Jiahui , Zhu Yumeng , Fang Yuan , Zhang Dale , Li Suoping
Published: May 2020

As the diploid progenitor of common wheat, Aegilops tauschii is considered to be a valuable resistance source to various biotic and abiotic stresses. However, little has been reported concerning the molecular mechanism of drought tolerance in Ae. tauschii. In this work, the drought tolerance of 155 Ae. tauschii accessions was firstly screened on the basis of their coleoptile lengths under simulated drought stress. Subsequently, two accessions (XJ002 and XJ098) with contrasting coleoptile lengths were selected and intensively analyzed on rate of water loss (RWL) as well as physiological characters, confirming the difference in drought tolerance at the seedling stage. Further, RNA-seq was utilized for global transcriptome profiling of the two accessions seedling leaves under drought stress conditions. A total of 6969 differentially expressed genes (DEGs) associated with drought tolerance were identified, and their functional annotations demonstrated that the stress response was mediated by pathways involving alpha-linolenic acid metabolism, starch and sucrose metabolism, peroxisome, mitogen-activated protein kinase (MAPK) signaling, carbon fixation in photosynthetic organisms, and glycerophospholipid metabolism. In addition, DEGs with obvious differences between the two accessions were intensively analyzed, indicating that the expression level of DEGs was basically in alignment with the physiological changes of Ae. tauschii under drought stress. The results not only shed fundamental light on the regulatory process of drought tolerance in Ae. tauschii, but also provide a new gene resource for improving the drought tolerance of common wheat.
Role of microRNAs in Hemophilia and Thrombosis in Humans
Authors: Jankowska Katarzyna I. , Sauna Zuben E. , Atreya Chintamani D.
Published: May 2020

MicroRNAs (miRNA) play an important role in gene expression at the posttranscriptional level by targeting the untranslated regions of messenger RNA (mRNAs). These small RNAs have been shown to control cellular physiological processes including cell differentiation and proliferation. Dysregulation of miRNAs have been associated with numerous diseases. In the past few years miRNAs have emerged as potential biopharmaceuticals and the first miRNA-based therapies have entered clinical trials. Our recent studies suggest that miRNAs may also play an important role in the pathology of genetic diseases that are currently considered to be solely due to mutations in the coding sequence. For instance, among hemophilia A patients there exist a small subset, with normal wildtype genes; i.e., lacking in mutations in the coding and non-coding regions of the F8 gene. Similarly, in many patients with missense mutations in the F8 gene, the genetic defect does not fully explain the severity of the disease. Dysregulation of miRNAs that target mRNAs encoding coagulation factors have been shown to disturb gene expression. Alterations in protein levels involved in the coagulation cascade mediated by miRNAs could lead to bleeding disorders or thrombosis. This review summarizes current knowledge on the role of miRNAs in hemophilia and thrombosis. Recognizing and understanding the functions of miRNAs by identifying their targets is important in identifying their roles in health and diseases. Successful basic research may result in the development and improvement of tools for diagnosis, risk evaluation or even new treatment strategies.
Acid Soil Improvement Enhances Disease Tolerance in Citrus Infected by Candidatus Liberibacter asiaticus
Authors: Li Bo , Wang Shuangchao , Zhang Yi , Qiu Dewen
Published: May 2020

Huanglongbing (HLB) is a devastating citrus disease that has caused massive economic losses to the citrus industry worldwide. The disease is endemic in most citrus-producing areas of southern China, especially in the sweet orange orchards where soil acidification has intensified. In this work, we used lime as soil pH amendment to optimize soil pH and enhance the endurance capacity of citrus against Candidatus Liberibacter asiaticus (CLas). The results showed that regulation of soil acidity is effective to reduce the occurrence of new infections and mitigate disease severity in the presence of HLB disease. We also studied the associated molecular mechanism and found that acid soil improvement can (i) increase the root metabolic activity and up-regulate the expression of ion transporter-related genes in HLB-infected roots, (ii) alleviate the physiological disorders of sieve tube blockage of HLB-infected leaves, (iii) strengthen the citrus immune response by increasing the expression of genes involved in SAR and activating the salicylic acid signal pathway, (iv) up-regulate 55 proteins related to stress/defence response and secondary metabolism. This study contributes to a better understanding of the correlation between environment factors and HLB disease outbreaks and also suggests that acid soil improvement is of potential value for the management of HLB disease in southern China.
The Influence of Local Pamidronate Application on Alveolar Dimensional Preservation after Tooth Extraction—An Animal Experimental Study
Authors: Kauffmann Frederic , Höhne Christian , Assaf Alexandre Thomas , Vollkommer Tobias , Semmusch Jan , Reitmeier Aline , Michel Stein Jamal , Heiland Max , Smeets Ralf , Rutkowski Rico
Published: May 2020

The aim of this randomized, controlled animal exploratory trial was to investigate the influence of local application of aminobisphosphonate pamidronate during the socket preservation procedure. Mandibular premolars were extracted in five Göttingen minipigs. Two animals underwent socket preservation using BEGO OSS (n = 8 sockets) and three animals using BEGO OSS + Pamifos (15 mg) (n = 12 sockets). After jaw impression, cast models (baseline, eight weeks postoperative) were digitized using an inLab X5 scanner (Dentsply Sirona) and the generated STL data were superimposed and analyzed with GOM Inspect 2018 (GOM, Braunschweig). After 16 weeks, the lower jaws were prepared and examined using standard histological methods. In the test group (BEGO OSS + pamidronate), buccooral dimensional loss was significantly lower, both vestibulary (−0.80 ± 0.57 mm vs. −1.92 ± 0.63 mm; p = 0.00298) and lingually (−1.36 ± 0.58 mm vs. −2.56 ± 0.65 mm; p = 0.00104) compared with the control group (BEGO OSS). The test group showed a significant difference between vestibular and lingual dimensional loss (p = 0.04036). Histology showed cortical and cancellous bone in the alveolar sockets without signs of local inflammation. Adjuvant application of pamidronate during socket preservation reduces alveolar dimensional loss significantly. Further investigations with regard to dose–response relationships, volume effects, side effects, and a verification of the suitability in combination with other bone substitute materials (BSMs) are necessary.
Comparison of the Characteristics and Outcomes of Coronavirus Disease 2019 in Different Types of Family Infections in Taiwan
Authors: Liu Shih-Feng , Kuo Nai-Ying , Kuo Ho-Chang
Published: May 2020

Background: There were some family infections of coronavirus disease 2019 (COVID-19) in Taiwan to date. This study aimed to investigate the clinical characteristics and outcomes of different types of family infections with COVID-19 and to share Taiwan’s experience. Material and methods: We collected cases of family infections of COVID-19 from 21 January 2020 to 16 March 2020. The data were collected from a series of press conference contents by Taiwan’s Central Epidemic Command Center (CECC). Results: During this period, there were six family infections in Taiwan, including two couple infections, one imported family cluster infection, and three domestic family cluster infections. Compared to the former two, the starters (cases 19, 24, and 27) of domestic family cluster infections showed longer symptom-onset to diagnosis (p = 0.02); longer symptom-onset to quarantine or isolation (p = 0.01); higher first-generation reproduction number (p = 0.03); and more critical presentation (endotracheal tube insertion and intensive care unit (ICU) care) (p < 0.01). In addition, compared to the former two, the starters of the latter were older, had no history of travel, and had more underlying diseases and more mortality. There are more contacts of domestic family cluster infections, making epidemiological investigations more difficult and expensive. However, the second-generation reproduction number of the above three families was zero. Conclusion: Domestic family cluster infections of COVID-19 have different characteristics and outcomes from couple infection and imported family cluster infections in this study.
Present and Future of Bronchopulmonary Dysplasia
Authors: Bonadies Luca , Zaramella Patrizia , Porzionato Andrea , Perilongo Giorgio , Muraca Maurizio , Baraldi Eugenio
Published: May 2020

Bronchopulmonary dysplasia (BPD) is the most common respiratory disorder among infants born extremely preterm. The pathogenesis of BPD involves multiple prenatal and postnatal mechanisms affecting the development of a very immature lung. Their combined effects alter the lung’s morphogenesis, disrupt capillary gas exchange in the alveoli, and lead to the pathological and clinical features of BPD. The disorder is ultimately the result of an aberrant repair response to antenatal and postnatal injuries to the developing lungs. Neonatology has made huge advances in dealing with conditions related to prematurity, but efforts to prevent and treat BPD have so far been only partially effective. Seeing that BPD appears to have a role in the early origin of chronic obstructive pulmonary disease, its prevention is pivotal also in long-term respiratory outcome of these patients. There is currently some evidence to support the use of antenatal glucocorticoids, surfactant therapy, protective noninvasive ventilation, targeted saturations, early caffeine treatment, vitamin A, and fluid restriction, but none of the existing strategies have had any significant impact in reducing the burden of BPD. New areas of research are raising novel therapeutic prospects, however. For instance, early topical (intratracheal or nebulized) steroids seem promising: they might help to limit BPD development without the side effects of systemic steroids. Evidence in favor of stem cell therapy has emerged from several preclinical trials, and from a couple of studies in humans. Mesenchymal stromal/stem cells (MSCs) have revealed a reparatory capability, preventing the progression of BPD in animal models. Administering MSC-conditioned media containing extracellular vesicles (EVs) have also demonstrated a preventive action, without the potential risks associated with unwanted engraftment or the adverse effects of administering cells. In this paper, we explore these emerging treatments and take a look at the revolutionary changes in BPD and neonatology on the horizon.
Associations of Sedentary Behaviour, Physical Activity, Cardiorespiratory Fitness and Body Composition with Risk of Sleep-Related Breathing Disorders in Children with Overweight/Obesity: A Cross-Sectional Study
Authors: Torres-Lopez Lucia V. , Cadenas-Sanchez Cristina , Migueles Jairo H. , Adelantado-Renau Mireia , Plaza-Florido Abel , Solis-Urra Patricio , Molina-Garcia Pablo , Ortega Francisco B.
Published: May 2020

The aim of this study was to examine the associations of sedentary behaviour, physical activity, cardiorespiratory fitness (CRF), and body composition parameters with risk of sleep-related breathing disorders (SRBD) in children with overweight/obesity. One-hundred and nine children (10.0 ± 1.1 years old, 45 girls) with overweight (n = 27) and obesity (n = 82) were included. Television viewing time was self-reported by using the Spanish adaptation of the “Youth Activity Profile” (YAP) questionnaire. Sedentary time and physical activity were measured with accelerometry. CRF was assessed with the 20-m shuttle-run test and body composition parameters with Dual-energy X-ray absorptiometry. SRBD were evaluated by using the Spanish version of the Pediatric Sleep Questionnaire. Television viewing time was positively associated with risk of SRBD (r = 0.222, p = 0.021). CRF was negatively correlated with risk of SRBD (r = −0.210, p = 0.030). Body composition parameters were positively associated with risk of SRBD (all p < 0.05), except fat mass index. Stepwise regression analyses showed that body mass index (BMI) explained the largest proportion of the variance in SRBD (r2 = 0.063, p = 0.01) and television viewing time was the only one added after BMI (r2 change = 0.048, p = 0.022). This study supports the notion that higher body weight status negatively influences risk of SRBD and adds that unhealthy behaviours could contribute to worsen SRBD, related to an increased risk of cardiovascular diseases. All the significant association observed in this manuscript were of small magnitude, indicating than other factors in addition to the one hereby studied contribute to explain the variance in SRBD.
Comparative Study of Contact Repulsion in Control and Mutant Macrophages Using a Novel Interaction Detection
Authors: Solís-Lemus José Alonso , Sánchez-Sánchez Besaiz J , Marcotti Stefania , Burki Mubarik , Stramer Brian , Reyes-Aldasoro Constantino Carlos
Published: May 2020

In this paper, a novel method for interaction detection is presented to compare the contact dynamics of macrophages in the Drosophila embryo. The study is carried out by a framework called macrosight, which analyses the movement and interaction of migrating macrophages. The framework incorporates a segmentation and tracking algorithm into analysing the motion characteristics of cells after contact. In this particular study, the interactions between cells is characterised in the case of control embryos and Shot mutants, a candidate protein that is hypothesised to regulate contact dynamics between migrating cells. Statistical significance between control and mutant cells was found when comparing the direction of motion after contact in specific conditions. Such discoveries provide insights for future developments in combining biological experiments with computational analysis.
Quality Performance Evaluation of Thin Walled PLA 3D Printed Parts Using the Taguchi Method and Grey Relational Analysis
Authors: Aslani Kyriaki-Evangelia , Chaidas Dimitrios , Kechagias John , Kyratsis Panagiotis , Salonitis Konstantinos
Published: May 2020

This paper investigates the quality performance of FDM 3D printed models with thin walls. The design of experiments method (DOE) was used and nine models of the same size were fabricated in a low-cost 3D printer using polylactic acid (PLA) material. Two limited studied parameters were considered (extraction temperature and wall thickness), each one having three levels. External X and Y dimensions were measured using a micrometer, as well as four surface roughness parameters (Ra, Rz, Rt, Rsm) with a surface tester. Two optimization techniques (the Taguchi approach and Grey relational analysis) were utilized along with statistical analysis to examine how the temperature and wall thickness affect the dimensional accuracy and the surface quality of the parts. The results showed that high extraction temperature and median wall thickness values optimize both dimensional accuracy and surface roughness, while temperature is the most important factor.
Corporate Governance and Agency Cost: Empirical Evidence from Vietnam
Authors: Huu Nguyen Anh , Thuy Doan Duong , Ha Nguyen Linh
Published: May 2020

This study examines the impact of corporate governance, reflecting a wide spectrum of board characteristics and ownership structure on agency costs in 281 listed companies on Ho Chi Minh Stock Exchange (HOSE) in Vietnam in the period 2013–2018. For this purpose, three board characteristics were chosen: (1) the size of board of directors, (2) equilibrium between non-executive and executive members of the board of directors, (3) the CEO chair duality and three types of ownership structures were chosen: (1) management ownership, (2) government ownership, (3) foreign ownership. An inverse proxy of agency costs is used: asset utilization ratio (asset turnover), which reflects the managerial efficiency. The research methodology includes three statistical approaches: Ordinary least squares (OLS), fixed effects model (FEM) and random effects model (REM) are considered to employ to address econometric issues and to improve the accuracy of the regression coefficients. The results can create effective corporate governance mechanisms in controlling the managerial opportunistic behavior to lower agency conflicts, and hence lower agency costs.
Delivering Climate-Development Co-Benefits through Multi-Stakeholder Forestry Projects in Madagascar: Opportunities and Challenges
Authors: Favretto Nicola , Afionis Stavros , Stringer Lindsay C. , Dougill Andrew J. , Quinn Claire H. , Ranarijaona Hery Lisy Tiana
Published: May 2020

This paper explores multi-stakeholder perspectives on the extent to which forestry projects that pursue ecological restoration and rehabilitation in Madagascar engage with local communities and can co-deliver climate-development benefits. Drawing on mixed methods (policy analysis, semi-structured interviews, participatory site visits and focus groups) in two different forestry contexts, we show that by strengthening access to capital availability, projects can enhance local adaptive capacity and mitigation and deliver local development. We show that active consideration of ecological conservation and action plans early in project design and implementation can co-develop and support monitoring and reporting systems, needed to progress towards integrated climate-compatible development approaches. Climate mitigation benefits remain poorly quantified due to limited interest in, and low capacity to generate, carbon revenues. Monitoring alone does not ensure carbon benefits will materialize, and this research stresses that institutional considerations and strengthened engagement and cooperation between practitioners and communities are key in achieving both climate mitigation and community development impacts. Multiple benefits can be fostered by aligning objectives of multiple landscape actors (i.e., community needs and project developers) and by systematically linking project deliverables, outputs, outcomes and impacts over time, grounded in a theory of change focused on ensuring community buy-in and planning for delivery of tangible benefits.
A Spatial-Temporal Analysis of the Effects of Households’ Land-use Behaviors on Soil Available Potassium in Cropland: A Case Study from Urban Peripheral Region in Northeast China
Authors: Liu Hongbin , Sun Zhanli , Luo Xiaojuan , Dong Xiuru , Wu Mengyao
Published: May 2020

Available potassium (AVK) in the soil of cropland is one of the most important factors determining soil quality and agricultural productivity. Thus, it is crucial to understand the variation of AVK and its influencing factors for sustaining soil fertility and mitigating land degradation. Farm households are the ultimate land users, and their land-use behaviors inevitably play an important role in the variation of AVK. This paper, therefore, aims to explore the effects of households’ land-use behaviors on soil AVK from spatial and temporal perspectives. Taking an urban peripheral region in Northeast China as the study area, we firstly use geostatistics (Kriging interpolation) and GIS tools to map out the spatial AVK distributions in 1980, 2000, and 2010, based on soil sampling data points, and then assess the impacts of land-use behaviors on AVK using econometric models. The results show that, although the AVK content in the study area has a largely downward trend over the 30 years, there are distinct trends in different stages. The disparity of trends can be attributed to the changes in households’ land-use behaviors over time. The spatial variation of AVK is also substantial and intriguing: the closer to the urban area, the greater the decline of soil AVK content, while the farther away from the urban area, the greater the rise of soil AVK content. This spatial disparity can too be largely explained by the obvious differences in households’ land-use behaviors in various regions.