bluuebunny/crossref_metadata_2025 huggingface dataset:
ThePasteur Institute and Its International Network
Authors: Moulin Anne Marie
Published: September 2015

The Pasteur Institute is a French institution pursuing unabated research in biomedical sciences since its creation in 1888. The institute has undergone in‐depth transformation while maintaining a triple orientation to research, teaching and applied sciences. The present International Pasteur Institutes network is composed of 32 centres scattered on the five continents, a powerful asset for its new function of surveillance of a global microbial world and contribution to Global Public Health. The Pastorian specificity is anchored in this long history and the esprit de corps of an international scientific community, sealed by anethicsin biomedical research that can conflict with the managerial transformations of the contemporary institution.

Key Concepts

The Pasteur Institute is a French centre of research in biomedical sciences.

Its specificity lies in its strong link to its founder Louis Pasteur's doctrines and character.

The International Pasteur Institute Network has developed branches all over the world.

The present challenge for the network is to concile ethics of research and economic concerns.
Genetic Information Access, a Legal Perspective: A Duty to Know or a Right Not to Know, and a Duty or Option to Warn?
Authors: Lemmens Trudo , Luther Lori , Hoy Michael
Published: September 2015

It is often argued that concern with basic personal privacy suggests that individuals should be allowed to decide in isolation whether to obtain genetic information through testing and whether to make the results available to others. However, the familial nature of genetic information complicates matters by raising question regarding whether an individual has a moral duty to discover and/or reveal existing genetic information to possibly affected family members. Alternatively, if this information would harm family members, do individuals have a duty not to obtain, or at least not to divulge, genetic test results? What role, if any, should legislation play in dealing with access to genetic information at the familial level? Do health care professionals have a responsibility or a right to inform close family members of the genetic status of a related individual? We consider the personal, familial and public health care perspectives regarding this debate.

Key Concepts

Many individuals face conflicting psychological effects regarding the anticipation of obtaining genetic test results.

Despite the potential usefulness of genetic information, the majority of individuals facing potentially devastating genetic diseases opt not to undergo testing.

Results of an individual's genetic tests are often of interest to family members which raises complications regarding individual privacy.

Controversy also surrounds the responsibility of health care professionals whether to maintain patient privacy or inform affected family members.

Courts and lawmakers struggle with the question whether individual privacy should be respected when genetic information may be of significant interest to family members.

Courts have recognized that in some circumstances, health care providers have an option to warn family members of a genetic risk, when there is a significant risk of a serious and avoidable harm.

A strong case can be made that, with few exceptions (e.g. PKU), genetic information should fall under the usual rules protecting individual privacy and confidentiality.

Future discoveries in genetic information may lead to more exceptions to the duty of confidentiality.
Primer on Protein–Protein Interaction Maps
Authors: Marín‐de la Rosa Nora , Braun Pascal
Published: September 2015

Interactions among proteins mediate regulatory, mechanical, structural and transport functions and are fundamental in the modulation of all cellular activities. About 15 years ago, it was first noted that physical interactions link most if not all proteins to each other in complex networks. The analysis of maps representing current knowledge about these molecular networks can provide insights that range from specific hypotheses on the function of a given protein to system‐level properties on the organisation or evolution of biological systems. Here, we provide an updated introduction to the numerous ways and available tools by which protein–protein interaction maps can be analysed, and caveats that need to be kept in mind.

Key Concepts

Protein–protein interaction maps are important tools to develop functional hypothesis, contextualise ‘omic’ gene lists, analyse system properties and systems evolution and provide an important basis for analysing system dynamics.

Networks can be assembled from small‐scale literature data, bioinformatic prediction and experimental high‐throughput technologies of which affinity‐purification followed by mass spectrometry or binary yeast‐based assays are most common.

Global and local properties of protein–protein interaction maps can be influenced by sociological, technological and experimental biases that need to be taken into account.

High‐throughput technologies can provide data that are in quality at least comparable to the high‐quality fraction from small‐scale studies in public databases.

Carefully benchmarked and appropriate quality controls must be implemented for all approaches.

Binary and co‐complex methodologies give rise to differential and complementary sets of protein interactions.

Bioinformatic tools are available that enable nonspecialists to analyse and use protein–protein interaction networks.
Early Modern/Renaissance Anatomy
Authors: Nutton Vivian
Published: September 2015

The learned practitioners of medicine at the beginning of the fourteenth century knew little about the structures and workings of the human body beyond what they had read in their books or gained from their experience of patients. Three hundred years later, anatomical study was a fundamental part of medical training throughout Western Europe, the dissection of human corpses was common in universities and enormous changes had occurred in the understanding of all aspects of the body. Anatomy, which encompassed what today includes physiology as well as anatomy itself, became the touchstone of the new medicine, and, thanks to the invention of printing, penetrated the cultural scene. Poems, plays, essays and images propagated to a wider public the results of dissection.
Impedimetric Monitoring of Cell‐Based Assays
Authors: Lukic Sonja , Wegener Joachim
Published: September 2015

Electrochemical impedance measurements (electric cell‐substrate impedance sensing, ECIS) have been established as a label‐free and noninvasive experimental tool to monitor and quantify the behaviour of adherent cells grown on planar gold‐film electrodes while they are exposed to chemical, biological or physical stimuli/stressors. Owing to the noninvasiveness of the measurement, impedance‐based cell observation provides continuous information about the cell response in real time. Different data acquisition modes in combination with tailored electrode layouts are used to assess the time courses of several fundamental processes in cell physiology such as cell adhesion, cell proliferation, cell migration, intracellular signal transduction or cell death. Experiments are performed entirely automated and computer‐controlled under regular cell culture conditions. State‐of‐the‐art instrumentation allows for the parallel analysis of up to 384 samples. Its multimodality and throughput suggest that ECIS can play a similar role for the analysis of cell‐based assays as flow cytometry.

Key Concepts

Electric cell‐substrate impedance sensing (ECIS) is a noninvasive experimental technique to monitor adherent cells
in vitro
along different types of biomedical or bioanalytical assays with a time resolution that is adjustable from milliseconds to hours.

To perform ECIS‐based assays, the cells are grown on planar gold‐film electrodes deposited on the surface of a regular cell culture dish. ECIS is compatible with regular cell culture conditions, fully automated and software controlled.

The approach is sensitive to (1) the fractional coverage of the electrode surface and (2) the three‐dimensional shape of the cells attached to the electrode.

ECIS is significantly more sensitive for cell shape changes than optical microscopy.

On the basis of this generic sensitivity, different assays have been developed to monitor cell adhesion to biomaterial surfaces, cell proliferation, cell migration, cell death or the stimulation of cell‐surface receptors.

The scope of available assay formats has been further extended using elevated electric fields for well‐defined cell manipulation integrated into continuous, impedance‐based cell monitoring (e.g.
in situ
electroporation).
Treatment, Right to Refuse: Mental Health
Authors: Christopher Sheresa , Vitacco Michael J.
Published: September 2015

Courts have consistently found that adults who are mentally competent have the right to refuse treatment, even if such treatment is considered in their best interests. Given the inherent complications that arise when trying to balance the best interests of patients with their right to refuse treatment, practitioners must be informed about the way in which this dilemma may influence their practice. The right to refuse treatment is viewed from the perspective of therapeutic jurisprudence, which maximizes the constitutional rights of individuals with mental illness. To improve our understanding of the right to refuse treatment, court cases addressing the right to refuse treatment are examined. We further discuss the influence of right to refuse on clinical practice. Specifically, we examine limits associated with the right to refuse including dangerousness, a compelling state interest, a grave medical need, and in some cases as a stipulation of parole. Finally, we provide key considerations regarding the right to refuse treatment relevant to both practitioners and legal advocates.
Hetero‐Nanonet Rechargeable Paper Batteries: Toward Ultrahigh Energy Density and Origami Foldability
Authors: Cho Sung‐Ju , Choi Keun‐Ho , Yoo Jong‐Tae , Kim Jeong‐Hun , Lee Yong‐Hyeok , Chun Sang‐Jin , Park Sang‐Bum , Choi Don‐Ha , Wu Qinglin , Lee Sun‐Young , Lee Sang‐Young
Published: September 2015

Forthcoming smart energy era is in strong pursuit of full‐fledged rechargeable power sources with reliable electrochemical performances and shape versatility. Here, as a naturally abundant/environmentally friendly cellulose‐mediated cell architecture strategy to address this challenging issue, a new class of hetero‐nanonet (HN) paper batteries based on 1D building blocks of cellulose nanofibrils (CNFs)/multiwall carbon nanotubes (MWNTs) is demonstrated. The HN paper batteries consist of CNF/MWNT‐intermingled heteronets embracing electrode active powders (CM electrodes) and microporous CNF separator membranes. The CNF/MWNT heteronet‐mediated material/structural uniqueness enables the construction of 3D bicontinuous electron/ion transport pathways in the CM electrodes, thus facilitating electrochemical reaction kinetics. Furthermore, the metallic current collectors‐free, CNF/MWNT heteronet architecture allows multiple stacking of CM electrodes in series, eventually leading to user‐tailored, ultrathick (i.e., high‐mass loading) electrodes far beyond those accessible with conventional battery technologies. Notably, the HN battery (multistacked LiNi0.5Mn1.5O4 (cathode)/multistacked graphite (anode)) provides exceptionally high‐energy density (=226 Wh kg−1 per cell at 400 W kg−1 per cell), which surpasses the target value (=200 Wh kg−1 at 400 W kg−1) of long‐range (=300 miles) electric vehicle batteries. In addition, the heteronet‐enabled mechanical compliance of CM electrodes, in combination with readily deformable CNF separators, allows the fabrication of paper crane batteries via origami folding technique.
Cyclopropenes for the Synthesis of Cyclopropane‐Fused Dihydroquinolines and Benzazepines
Authors: Luo Hui‐Xin , Niu You‐Hong , Cao Xiao‐Ping , Ye Xin‐Shan
Published: September 2015

An efficient method for the construction of cyclopropane‐fused dihydroquinolines was established by a novel Povarov‐type three‐component reaction of aromatic aldehydes, anilines and cyclopropenes in the presence of trifluoromethanesulfonic acid. The reaction proceeded in a regioselective and diastereoselective manner. Furthermore, the dihydroquinolines were smoothly converted to benzazepine derivatives via a ring opening/isomerization sequence, further expanding the synthetic scope.

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Synthesis of Tetrasubstituted Pyrroles from Homopropargylic Amines via a Sonogashira Coupling/Intramolecular Hydroamination/Oxidation Sequence
Authors: Wang Chan , Huang Kaimeng , Wang Junying , Wang Hongkai , Liu Lingyan , Chang Weixing , Li Jing
Published: September 2015

A one‐pot reaction of homopropargylic amines and aryl iodides was developed in the presence of a palladium (Pd) catalyst and generated a series of tetrasubstituted pyrrole derivatives in good to high yields. This process involved a Sonogashira, intramolecular hydroamination, cyclization and oxidation sequence of reactions.

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Audience effects, but not environmental influences, explain variation in gorilla close distance vocalizations—A test of the acoustic adaptation hypothesis
Authors: Hedwig Daniela , Mundry Roger , Robbins Martha M. , Boesch Christophe
Published: September 2015

Close distance vocalizations are an integral part of primate vocal communication. They exhibit large acoustic variation which has been suggested to constitute flexible responses to the highly variable social setting of group living animals. However, a recent study suggested that acoustic variation in close distance calls of baboons may also arise from acoustic adaptations to environmental factors in order to counteract sound degradation. We tested whether the variation in calling rate and acoustic structure of gorilla close distance vocalizations may serve to counteract distorting effects of vegetation during sound propagation. Using focal animal sampling we recorded the vocal behavior of 15 adult individuals living in two groups: one group of western lowland gorillas Gorilla gorilla gorilla and one group of mountain gorillas Gorilla beringei beringei. We considered the distance between the caller and its nearest neighbor as the minimum transmission distance of calls; while vegetation density was quantified through measures of visibility. Our analysis revealed vocal plasticity in gorilla close calls in relation to changes in visibility and nearest neighbor distance. However, the observed changes in fundamental frequency and calling rate are unlikely to counteract degrading effects of vegetation, but rather seem to reflect reactions to variation in spatial and visual separation from other group members, similar to the audience effects demonstrated in a range of other species. We propose that vocal plasticity to counteract distorting environmental effects may not be prevalent across taxa and perhaps confined to species living in heterogeneous habitats with highly variable transmission conditions. Am. J. Primatol. 77:1239–1252, 2015. © 2015 Wiley Periodicals, Inc.
Governance for Effective Policy‐Relevant Scientific Research: The Shared Governance Model
Authors: Burgman Mark
Published: September 2015

Despite the aligned aspirations of many applied scientists and policy‐makers that science should contribute directly to policy decisions, there are significant gaps between what scientists provide and what policy‐makers can use. This article outlines the features that encourage effective adoption of scientific advice in public policy. It reviews some of the major impediments to its use. It describes governance mechanisms that aim to overcome these impediments, and discusses their strengths and weaknesses. Opportunities exist for designing governance mechanisms that will better support the development and persistence of the personal relationships that underpin the most effective delivery of science for policy.
Explaining the Role of Parental Education in the Regional Variations in Infant Mortality in India
Authors: Choudhury Pradeep Kumar
Published: September 2015

Using data from the National Family Health Survey (2005–06), this study examines the effect of parental education and the related factors (mother's exposure to mass media and her socio‐economic empowerment) in the regional variations in infant mortality in India. The study finds that parental education is significantly associated with reducing infant mortality to a varying degree at the regional level. It is also evident that children born to mothers having any kind of exposure to the mass media are less likely to die during infancy compared with children born to mothers having no mass media exposure. More importantly, parental education works better in regions that are socio‐economically underdeveloped. The findings of the study place emphasis on imparting education to mothers along with mass media exposure and higher level of socio‐economic empowerment to reduce infant deaths in India and also to minimise its glaring regional variations.
Aiding Women Candidates in Solomon Islands: Suggestions for Development Policy
Authors: Wood Terence
Published: September 2015

This article discusses the poor performance of women candidates in Solomon Islands elections and potential aid policy responses. The article outlines women candidates' performance, details challenges faced by women, examines existing aid work designed to help women candidates and provides policy suggestions. The article argues that existing aid policy focused on candidate training and voter education has achieved little because the main impediments women candidates face are access to finance and local gatekeepers, alongside more subtle normative constraints. These are barriers that are not easily shifted by training or education programs. Meanwhile, for reasons of political economy, another area of aid‐supported engagement, a parliamentary gender quota, is unlikely to be enacted. Reflecting this, and the nature of the challenges women candidates face, the article recommends donors also undertake work to help prospective women candidates engage with communities over time, building ties and reputations as providers of assistance.
Radiotherapy and locally advanced rectal cancer
Authors: Glynne-Jones R , Hall M
Published: September 2015

Blanket use of radiotherapy unwarranted
CFD modeling for the estimation of pressure loss coefficients of pipe fittings: An undergraduate project
Authors: Perumal Kumar , Ganesan Rajamohan
Published: September 2015

This work reports the outcomes of a senior undergraduate project done as part of a CFD course offered at Curtin University, Malaysia. Pressure loss coefficients for single phase flow through 90 degree bend has been estimated using CFD simulation. It is evident from the results that a validated CFD model is a reliable and cheap tool for loss coefficient estimation of any combination of pipe fitting and complex fluid / flow. © 2015 Wiley Periodicals, Inc. Comput Appl Eng Educ 24:180–185, 2016; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21695
Consecutive percutaneous valve‐in‐valve replacement late after ross procedure: A novel approach in an adult with congenital heart disease
Authors: Wiktor Dominik M. , Kay Joseph D. , Kim Michael S.
Published: September 2015

The emergence of transcatheter valve technology over the last decade has made significant impact on the treatment of patients with valvular heart disease. There has been increasing experience with both native and valve‐in‐valve indications with promising results. We present the case of a young woman with congenital heart disease who underwent the Ross procedure for bicuspid aortic valve endocarditis with subsequent reoperation and surgical aortic valve replacement for neo‐aortic root dilation who experienced worsening symptoms related to both pulmonary and aortic valve dysfunction. She was successfully treated with percutaneous pulmonary and aortic valve replacement with excellent early term technical results and marked improvement in symptoms. © 2015 Wiley Periodicals, Inc.
No reflow leading to catastrophic hemodynamic collapse in a patient with severe aortic stenosis and its management
Authors: Singh Rao Ravinder , Shapiro Robert L. , Lasala John M.
Published: September 2015

We report a case of an 87‐year‐old female who underwent percutaneous coronary intervention (PCI) for non‐ST elevation myocardial infarction while she was being worked up for transcatheter aortic valve procedure. Hemodynamic compromise occurred during the PCI, which could only be mitigated by doing a balloon aortic valvuloplasty and Impella™ insertion. This case report will help in preparedness for any untoward events in patients with aortic stenosis and undergoing percutaneous coronary intervention. © 2015 Wiley Periodicals, Inc.
Ischemic Postconditioning After Routine Thrombus Aspiration During Primary Percutaneous Coronary Intervention: Rationale and Design of the POstconditioning Rotterdam Trial
Authors: Yetgin Tuncay , van Kranenburg Matthijs , ten Cate Tim , Duncker Dirk J. , de Boer Menko‐Jan , Diletti Roberto , van Geuns Robert‐Jan M. , Zijlstra Felix , Manintveld Olivier C.
Published: September 2015

Background

Whether ischemic postconditioning (IPOC) immediately after routine thrombus aspiration (TA) reduces infarct size (IS) in patients with ST‐segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) has not been established.

Study design

The POstconditioning Rotterdam Trial (PORT) is a dual‐center, prospective, open‐label, randomized trial with blinded endpoint evaluation enrolling 72 subjects with first‐time STEMI, and an occluded infarct‐related artery (IRA) without collaterals undergoing PPCI. Subjects are randomized 1:1 to a strategy of IPOC immediately after TA followed by stenting of the IRA or to conventional percutaneous coronary intervention (PCI), including TA followed by stenting of the IRA (controls). Cardiac magnetic resonance imaging (MRI) is performed at 3–5 days after STEMI and at 3 months. The primary endpoint is IS at 3 months measured by delayed enhancement MRI. Other secondary endpoints include MRI‐derived microvascular obstruction (MVO), left ventricular ejection fraction, myocardial salvage index, enzymatic IS, ST‐segment resolution, myocardial blush grade, microcirculatory resistance, inflammation markers, and clinical events through 3‐month follow‐up.

Conclusions

PORT is testing the hypothesis that adding IPOC (against lethal reperfusion injury) to TA (against distal embolization and MVO) is cardioprotective and reduces ultimate IS in STEMI patients undergoing PPCI (Dutch Trial Register identifier: NTR4040). © 2015 Wiley Periodicals, Inc.
Photochemical Fluorination Reactions – A Promising Research Field for Continuous‐Flow Synthesis
Authors: Rehm Thomas H.
Published: September 2015

The unique properties of fluorine resulting from its tremendously high electronegativity make it a key player in the quest of enabling new and advanced qualities for chemical compounds and materials. With the advent of fluorinating reagents, a great diversity of synthetic methodologies has been developed to incorporate fluorine or fluorine‐containing groups into small molecules with high conversion and selectivity. Especially photochemically catalyzed fluorination reactions proved their potential for the synthesis of fluorine‐containing fine chemicals due to their mild reaction conditions. This tutorial review gives an overview of recently published synthesis strategies that use (visible‐) light‐absorbing catalysts for the activation of fluorinating reagents. A special focus lies on the use of continuous‐flow microreactors for photochemically catalyzed fluorination reactions due to the excellent utilization of this reactor equipment for photochemistry.
ChemInform Abstract: Nanoindentation, High‐Temperature Behavior, and Crystallographic/Spectroscopic Characterization of the High‐Refractive‐Index Materials TiTa2O7 and TiNb2O7.
Authors: Perfler Lukas , Kahlenberg Volker , Wikete Christoph , Schmidmair Daniela , Tribus Martina , Kaindl Reinhard
Published: September 2015

Colorless single crystals of TiTa2O7 and TiNb2O7 are prepared by melting stoichiometric mixtures of Nb2O5 or Ta2O5, and TiO2 at 1973 and 1873 K, respectively.
ChemInform Abstract: Hybrid Germanium Iodide Perovskite Semiconductors: Active Lone Pairs, Structural Distortions, Direct and Indirect Energy Gaps, and Strong Nonlinear Optical Properties.
Authors: Stoumpos Constantinos C. , Frazer Laszlo , Clark Daniel J. , Kim Yong Soo , Rhim Sonny H. , Freeman Arthur J. , Ketterson John B. , Jang Joon I. , Kanatzidis Mercouri G.
Published: September 2015

AGeI3 (A: Cs+ (I), MeNH3+ (II), HC(NH2)2+ (III), CH3C(NH2)2+ (IV), C(NH2)3+ (V), Me3NH+ (VI), iPrNH3+ (VII)) polar hybrid inorganic/organic semiconductors are prepared from a solution of GeI4 in aqueous HI and H3PO2 by precipitation and crystallization through the addition of stoichiometric amounts of AI (stirring at 120 °C until half of the solution is evaporated, 25 °C, 24 h, 80‐90% yield).
ChemInform Abstract: Solar Hydrogen Production by Amorphous Silicon Photocathodes Coated with a Magnetron Sputter Deposited Mo2C Catalyst.
Authors: Morales‐Guio Carlos G. , Thorwarth Kerstin , Niesen Bjoern , Liardet Laurent , Patscheider Joerg , Ballif Christophe , Hu Xile
Published: September 2015

A 5 nm Mo2C film is deposited on an amorphous Si photocathode by confocal magnetron co‐sputtering.
ChemInform Abstract: Synthesis and Electrochemical Investigation of Novel Phosphite Based Layered Cathodes for Li‐Ion Batteries.
Authors: Hameed A. Shahul , Reddy M. V. , Sarkar Nirjhar , Chowdari B. V. R. , Vittal Jagadese J.
Published: September 2015

M2 [(VO)2(HPO3)2(C2O4)] (M: Li, Na, K) are prepared by hydrothermal reaction of an aqueous mixture of V2O5, H2C2O4, MOH, and H3PO3 (autoclave, 120 °C, 2 d, 80‐90% yield) followed by dehydration at 150 °C (200 °C for the Li compound) in vacuum.
ChemInform Abstract: Direct Synthesis of Hexagonal NaGdF4 Nanocrystals from a Single‐Source Precursor: Upconverting NaGdF4:Yb3+,Tm3+ and Its Composites with TiO2 for Near‐IR‐Driven Photocatalysis.
Authors: Chen Ying , Mishra Shashank , Ledoux Gilles , Jeanneau Erwann , Daniel Marlene , Zhang Jinlong , Daniele Stephane
Published: September 2015

A single source precursor, NaGd(tfa)4(diglyme) is prepared from a THF solution of Na(tfa), Gd(tfa)3(H2O), and diglyme (room temperature, 5 h; 83% yield).
ChemInform Abstract: Solution‐Phase Conversion of Bulk Metal Oxides to Metal Chalcogenides Using a Simple Thiol—Amine Solvent Mixture.
Authors: McCarthy Carrie L. , Webber David H. , Schueller Emily C. , Brutchey Richard L.
Published: September 2015

A solvent mixture of en together with Et‐SH, HS‐(CH2)2‐OH, or HS‐(CH2)2‐SH is used to dissolve Cu2O, ZnO, GeO2, As2O3, Ag2O, CdO, SnO, Sb2O3, PbO, and Bi2O3 at 25 °C.
ChemInform Abstract: Coffinite, USiO4, Is Abundant in Nature: So Why Is It So Difficult to Synthesize?
Authors: Mesbah Adel , Szenknect Stephanie , Clavier Nicolas , Lozano‐Rodriguez Janeth , Poinssot Christophe , Den Auwer Christophe , Ewing Rodney C. , Dacheux Nicolas
Published: September 2015

Conditions are established under which coffinite can be reproducibly synthesized.
ChemInform Abstract: A2MnU3O11 (A: K, Rb) and Li3.2Mn1.8U6O22: Three New Alkali‐Metal Manganese Uranium(VI) Oxides Related to Natrotantite.
Authors: Read Cory Michael , Morrison Gregory , Yeon Jeongho , Smith Mark D. , zur Loye Hans‐Conrad
Published: September 2015

Single crystals of the title compounds are prepared from molten chloride fluxes using U3O8, MnCl2, and KCl, RbCl, or LiCl as starting materials (alumina crucible, 900—950 °C, 12 h, 70 and 90% yield for Rb2MnU3O11 and K2MnU3O11, respectively).
ChemInform Abstract: Pb2PdO2(OH)2 and Pb2PdO(OH)4(H2O): Synthesis and Crystal Growth at Ambient Conditions.
Authors: Komarek Alexander Christoph , Merz Patrick , Guo Hanjie , Suard Emmanuelle , Chen Jin‐Ming , Felser Claudia , Jansen Martin
Published: September 2015

The crystal structures of the new compounds (III) and (IV) are determined by powder neutron diffraction and single crystal XRD.
ChemInform Abstract: Ba2 [Pd(HS2O7)2 (S3O10)2]: A Heteroleptic Polysulfatopalladate.
Authors: Bruns Joern , Kluener Thorsten , Wickleder Mathias S.
Published: September 2015

Oxidation of Pd with oleum (65% SO3) in the presence of BaCO3 (sealed glass ampoules, 180 °C) results in single crystals of Ba2 [Pd(HS2O7)2 (S3O10)2] which crystallize in the triclinic space group P$\bar 1$ (Z = 1, single crystal XRD) and show Pd2+ in a square‐planar coordination of O atoms from two [HS2O7] and two [S3O10] anions.
ChemInform Abstract: Diphenylprolinol Silyl Ether‐Derived Thioureas as Highly Efficient Catalysts for the Asymmetric Michael Addition of Aldehydes to Nitroalkenes.
Authors: He Chunyan , Ren Xiaochen , Feng Yingle , Chai Yonghai , Zhang Shengyong , Chen Weiping
Published: September 2015

It is found that the spatial placement of the C‐4 substituent on the pyrrolidine ring of the catalyst has high influence on the reactivity, diastereoselectivity, and enantioselectivity.
ChemInform Abstract: Generation of Cycloheptynes and Cyclooctynes via a Sulfoxide—Magnesium Exchange Reaction of Readily Synthesized 2‐Sulfinylcycloalkenyl Triflates.
Authors: Yoshida Suguru , Karaki Fumika , Uchida Keisuke , Hosoya Takamitsu
Published: September 2015

Cycloheptynes and cyclooctynes are efficiently generated via a sulfoxide—magnesium exchange reaction of readily synthesized 2‐sulfinylcycloalkenyl triflates.
ChemInform Abstract: Organic Inorganic Hybrid Cobalt Phthalocyanine/Polyaniline as Efficient Catalyst for Aerobic Oxidation of Alcohols in Liquid Phase.
Authors: Panwar Vineeta , Kumar Pawan , Ray Siddharth S. , Jain Suman L.
Published: September 2015

The heterogeneous title reaction exhibits superior activity compared to homogeneous cobalt phthalocyanine catalysts with added benefits of easy recovery and recycling.
ChemInform Abstract: Highly Diastereoselective Cobalt‐Mediated C(sp3)—C(sp2) Cross‐Coupling Reactions of Cyclic Halohydrins with (Hetero)Aryl Grignard Reagents.
Authors: Hammann Jeffrey M. , Haas Diana , Steib Andreas K. , Knochel Paul
Published: September 2015

In addition to the transformation of O‐Tbs‐protected 2‐bromo and 2‐iodopentan‐1‐ols or the corresponding hexan‐1‐ols, respectively, the title reaction is also applied to a heterocyclic pyrrolidine‐derived iodohdydrin.
ChemInform Abstract: Polyethylene Glycol Functionalized Magnetic Dicationic Ionic Liquids as a Novel Catalyst and Their Application in Ring Opening of Epoxides in Water.
Authors: Godajdar Bijan Mombeni , Mombeni Sare
Published: September 2015

The title compound is prepared starting from PEG‐400 and used as magnetic phase transfer catalyst in the synthesis of 1,2‐azidoalcohols (II) and (IV).
ChemInform Abstract: An Efficient, Mild, Solvent‐Free, One‐Pot Three‐Component Mannich Reaction Catalyzed by (C4H12N2)2 [BiCl6]Cl·H2O.
Authors: Lu Hongfei , Wu Runze , Cheng Helong , Nie Shipeng , Tang Yan , Gao Yuhua , Luo Zhibin
Published: September 2015

The reaction starts from aromatic ketones, (hetero)aryl or cycloalkyl aldehydes and primary or secondary alkyl amines or (hetero)aryl amines.
ChemInform Abstract: Cobalt(III)‐Catalyzed C—H Bond Amidation with Isocyanates.
Authors: Hummel Joshua R. , Ellman Jonathan A.
Published: September 2015

The air‐ and moisture‐stable catalyst is highly efficient in the amidation of 1‐arylpyrazoles.
ChemInform Abstract: α‐Alkyl‐α‐aryl (Trimethyltin) Nitriles: Versatile Nucleophilic Intermediates in Aldol‐Like Reactions.
Authors: Qin Wenling , Long Sha , Bongini Alessandro , Panunzio Mauro
Published: September 2015

Trimethyltin nitriles either generated in situ or introduced directly readily react with carbonyl compounds to yield β‐hydroxynitriles.
ChemInform Abstract: Trifluoromethylthiolation of Aryl Iodides and Bromides Enabled by a Bench‐Stable and Easy‐To‐Recover Dinuclear Palladium(I) Catalyst.
Authors: Yin Guoyin , Kalvet Indrek , Schoenebeck Franziska
Published: September 2015

Trifluoromethylthiolation of aryl iodides and bromides in high yields is achieved by the robust dinuclear title catalyst.
ChemInform Abstract: Copper‐Catalyzed Intermolecular Trifluoromethylthiocyanation of Alkenes: Convenient Access to CF3‐Containing Alkyl Thiocyanates.
Authors: Liang Zhaoli , Wang Fei , Chen Pinhong , Liu Guosheng
Published: September 2015

Togni reagent II (II) and isothiocyanate (III) represent a highly effective combination for the title reaction.
ChemInform Abstract: Regioselective Suzuki Couplings of Non‐symmetric Dibromobenzenes: Alkenes as Regiochemical Control Elements.
Authors: Zhao Peng , Young Marshall D. , Beaudry Christopher M.
Published: September 2015

The Suzuki cross‐coupling reaction of non‐symmetric dibromobenzenes is investigated.
ChemInform Abstract: Cinchonidinium Acetate as a Convenient Catalyst for the Asymmetric Synthesis of cis‐Stilbenediamines.
Authors: Walvoord Ryan R. , Kozlowski Marisa C.
Published: September 2015

The scalable procedure provides cis‐stilbenediamines with moderate enatiomeric excess which may be improved via recrystallization.
ChemInform Abstract: Silver‐Catalyzed Direct Thiolation of Quinones by Activation of Aryl Disulfides to Synthesize Quinonyl Aryl Thioethers.
Authors: Zhang Cheng , McClure Jesse , Chou C. James
Published: September 2015

The optimized conditions allow a preparation of various target compounds with good to excellent yields.
ChemInform Abstract: Superacid‐Promoted Dual C—C Bond Formation by Friedel—Crafts Alkylation/Acylation of Cinnamate Esters: Synthesis of Indanones.
Authors: Ramulu Bokka Venkat , Niharika Pedireddi , Satyanarayana Gedu
Published: September 2015

In the case of cinnamic esters (I), the indanone is formed by cyclization of the more electron‐rich aryl moiety: arene reactant for (III), (V), (VII)/(VIII) and (IX) or cinnamic ester for (X) and (XII).
ChemInform Abstract: Cu(OAc)2‐Promoted Reaction of [60]Fullerene with Primary Amines or Diamines.
Authors: Lu Xin‐Wei , Xing Meng‐Lei , Miao Chun‐Bao , Li Jia‐Xing , Sun Xiao‐Qiang , Yang Hai‐Tao
Published: September 2015

The title reaction allows the concise preparation of aziridinofullerenes.
ChemInform Abstract: The Copper‐Catalyzed Asymmetric Construction of a Dispiropyrrolidine Skeleton via 1,3‐Dipolar Cycloaddition of Azomethine Ylides to α‐Alkylidene Succinimides.
Authors: Yang Wu‐Lin , Liu Yang‐Zi , Luo Shuai , Yu Xingxin , Fossey John S. , Deng Wei‐Ping
Published: September 2015

A series of chiral dispiropyrrolidines (III), (V), and (VII) is readily prepared by a copper‐catalyzed 1,3‐dipolar cycloaddition of azomethine ylides (II) and (IV) to α‐alkylidene succinimides (I) and (VI), respectively.
ChemInform Abstract: A Cinchona Alkaloid Catalyzed Enantioselective Sulfa‐Michael/Aldol Cascade Reaction of Isoindigos: Construction of Chiral Bispirooxindole Tetrahydrothiophenes with Vicinal Quaternary Spirocenters.
Authors: Gui Yong‐Yuan , Yang Jian , Qi Liang‐Wen , Wang Xiao , Tian Fang , Li Xiao‐Nian , Peng Lin , Wang Li‐Xin
Published: September 2015

The first protocol for the asymmetric preparation of the highly congested title compounds by an organocatalytic cascade reaction is presented.
ChemInform Abstract: Suzuki—Miyaura Reactions of Halospirooxindole Derivatives.
Authors: El Bouakher Abderrahman , Allouchi Hassan , Abrunhosa‐Thomas Isabelle , Troin Yves , Guillaumet Gerald
Published: September 2015

Based on the regioselective mono‐ and dibromination of spirofuroindoline (I) an efficient synthesis of mono‐ and diarylated products is developed.
ChemInform Abstract: Synthesis of Thiiranes by Rhodium‐Catalyzed Sulfur Addition Reaction to Reactive Alkenes.
Authors: Arisawa Mieko , Ichikawa Takuya , Yamaguchi Masahiko
Published: September 2015

A rhodium complex derived from RhH(PPh3)4, dppe, and 4‐ethynyltoluene catalyzes the addition reaction of sulfur to norbornenes giving the corresponding thiiranes.
ChemInform Abstract: Pt‐Catalyzed Rearrangement of Oxaspirohexanes to 3‐Methylenetetrahydrofurans: Scope and Mechanism.
Authors: Malapit Christian A. , Chitale Sampada M. , Thakur Meena S. , Taboada Rosa , Howell Amy R.
Published: September 2015

An unprecedented rearrangement is detected during the attempt to open the cyclopropane ring in oxaspirohexanes for the preparation of psico‐nucleoside synthons.
ChemInform Abstract: Design, Synthesis, and Application of a Chiral Sulfinamide Phosphine Catalyst for the Enantioselective Intramolecular Rauhut—Currier Reaction.
Authors: Su Xiao , Zhou Wei , Li Yangyan , Zhang Junliang
Published: September 2015

A novel class of chiral phosphine catalysts is introduced and successfully employed in the enantioselective intramolecular Rauhut‐Currier reaction.
ChemInform Abstract: Phosphine‐Free Palladium‐Catalyzed Direct Bisarylation of Pyrroles with Aryl Iodides on Water.
Authors: Cho Beom Shin , Bae Hyun Jung , Chung Young Keun
Published: September 2015

A broad spectrum of 2,5‐diarylated pyrroles is readily available under mild conditions.
ChemInform Abstract: The Chemistry of Vicinal Tricarbonyls: An Expedient Route to Fully‐Substituted 3‐Aminopyrroles.
Authors: Truong Phong M. , Mandler Michael D. , Doyle Michael P.
Published: September 2015

The synthesis is based on the one‐pot four‐component reaction of a 2,3‐diketoester, a primary amine and an aryl aldehyde or formaldehyde.
ChemInform Abstract: PyBidine—NiCl2‐Catalyzed Asymmetric Addition of Alcohols and Peroxides to Isatin‐Derived Ketimines.
Authors: Arai Takayoshi , Tsuchiya Kento , Matsumura Eri
Published: September 2015

MeOH (II) and peroxide (V) are found to be the optimal reactants for the title process in the presence of the chiral ligand PBPA.
ChemInform Abstract: Maleimide as an Efficient Nucleophilic Partner in the Aza‐Morita—Baylis—Hillman Reaction: Synthesis of Chiral 3‐Substituted‐3‐aminooxindoles.
Authors: Kumar Akshay , Sharma Vivek , Kaur Jasneet , Kumar Naveen , Chimni Swapandeep Singh
Published: September 2015

An organocatalytic enantioselective Aza‐Morita—Baylis—Hillman Reaction of maleimide derivatives with various N‐substituted isatin imine derivatives by employing chiral β‐isocupreidine as a catalyst is developed.
ChemInform Abstract: A Facile, Superacid‐Promoted Sequential Domino One‐Pot Dual C—C Bond Formation and Fischer Indole Synthesis: Rapid Access to 10‐Phenyl‐5,10‐dihydroindeno[1,2‐b]indoles.
Authors: Reddy Alavala Gopi Krishna , Satyanarayana Gedu
Published: September 2015

TfOH‐mediated reaction between cinnamic esters (I) and arenes initially furnishes indanones, e.
ChemInform Abstract: Organocatalyzed CO2 Trapping Using Alkynyl Indoles.
Authors: Xin Zhuo , Lescot Camille , Friis Stig D. , Daasbjerg Kim , Skrydstrup Troels
Published: September 2015

This first organocatalyzed trapping of CO2 gives access to new heterocyclic structures.
ChemInform Abstract: Silver(I) NHC Mediated C—C Bond Activation of Alkyl Nitriles and Catalytic Efficiency in Oxazoline Synthesis.
Authors: Heath Rachael , Mueller‐Bunz Helge , Albrecht Martin
Published: September 2015

The reaction of Ag2O in refluxing MeCN with triazolium iodide leads to the formation of Ag‐NHC complexes via selective C—C bond cleavage and from C—CN bond activation.
ChemInform Abstract: BF3‐Mediated cis‐Selective Cycloaddition of O‐Silyloxime with Alkenes.
Authors: Morita Nobuyoshi , Kono Rina , Fukui Kenji , Miyazawa Asuka , Masu Hyuma , Azumaya Isao , Ban Shintaro , Hashimoto Yoshimitsu , Okamoto Iwao , Tamura Osamu
Published: September 2015

O‐Silyloxime (I) reacts with alkenes (II) and Boc2O to the Boc‐protected isoxazolidin‐3‐carboxamides (IV) and (V) favouring the cis‐isomer (IV).
ChemInform Abstract: Novel, One‐Pot, Three‐Component, Regioselective Synthesis of Fluorine‐Containing Thiazole and Bis‐3H‐thiazole Derivatives Using Polyvinyl Pyridine as Heterogeneous Catalyst, and Evaluation of Their Antibacterial Activity.
Authors: Abbasi Shiran Jafar , Yahyazadeh Asieh , Mamaghani Manouchehr , Yamin Bohari M. , Albadi Jalal , Shirini Farhad , Rassa Mehdi
Published: September 2015

Eleven title compounds of type (IV) and four of type (VIII) are prepared by this new polyvinylpyridine‐catalyzed one‐pot, three‐component procedure.
ChemInform Abstract: A Green Synthesis of Substituted Coumarins Using Nano Graphene Oxide as Recyclable Catalyst.
Authors: Khodabakhshi Saeed , Marahel Farzaneh , Rashidi Alimorad , Abbasabadi Masoud Khaleghi
Published: September 2015

Graphene oxide nanosheets are used as efficient catalyst in one‐pot syntheses of pyranocoumarins (IV) and biscoumarins (V).
ChemInform Abstract: Stereoselective Construction of Functionalized Tetracyclic and Pentacyclic Coumarinopyranpyrazole/Pyrimidinedione/Coumarin Scaffolds Using a Solid‐State Melt Reaction.
Authors: Bakthadoss Manickam , Kannan Damodharan , Sivakumar Nagappan , Malathi Palani , Manikandan Vasudevan
Published: September 2015

A simple and novel protocol for the facile synthesis of complex angularly substituted tetracyclic and pentacyclic hybrid molecular frameworks containing a coumarinopyranpyrazole/pyrimidinedione and coumarin ring systems via a solid‐state melt reaction (SSMR) through a domino process is developed.
ChemInform Abstract: Pd/Pivalic Acid Mediated Direct Arylation of 2‐Pyrones and Related Heterocycles.
Authors: Pardo Leticia M. , Prendergast Aisling M. , Nolan Marie‐T. , O Muimhneachain Eoin , McGlacken Gerard P.
Published: September 2015

An oxidative direct intramolecular C‐H arylation of 2‐pyrone and 2‐pyridone derivatives bearing ortho‐halogenated benzyloxy groups is developed.
ChemInform Abstract: Knoevenagel‐Michael‐Cyclocondensation Tandem Reaction of Malononitrile, Various Aldehydes and Dimedone Catalyzed by Sulfonic Acid Functionalized Pyridinium Chloride as a New Ionic Liquid and Catalyst.
Authors: Zolfigol Mohammad Ali , Khazaei Ardeshir , Moosavi‐Zare Ahmad Reza , Afsar Javad , Khakyzadeh Vahid , Khaledian Omid
Published: September 2015

Sulfonic acid functionalized pyridinium chloride is prepared and used for the one‐pot synthesis of tetrahydrobenzo[b]pyran derivatives (IV) as a reusable catalyst under solvent‐free conditions.
ChemInform Abstract: Metal‐Free C(3)—H Arylation of Coumarins Promoted by Catalytic Amounts of 5,10,15,20‐Tetrakis(4‐diethylaminophenyl)porphyrin.
Authors: Kojima Masahiro , Oisaki Kounosuke , Kanai Motomu
Published: September 2015

This new, mild and environmentally friendly Meerwein arylation provides facile access to a broad variety of 3‐arylcoumarins in good yields.
ChemInform Abstract: Domino Acylation/Diels—Alder Synthesis of N‐Alkyl‐octahydroisoquinolin‐1‐one‐8‐carboxylic Acids under Low‐Solvent Conditions.
Authors: Slauson Stephen R. , Pemberton Ryan , Ghosh Partha , Tantillo Dean J. , Aube Jeffrey
Published: September 2015

Optimized condition sequences render possible the approach to the desired isoquinoline structures and the analogous lactone (VII).
ChemInform Abstract: PhI(OCOCF3)2‐Mediated Cyclization of o‐(1‐Alkynyl)benzamides: Metal‐Free Synthesis of 3‐Hydroxy‐2,3‐dihydroisoquinoline‐1,4‐dione.
Authors: Yang Chao , Zhang Xiang , Zhang‐Negrerie Daisy , Du Yunfei , Zhao Kang
Published: September 2015

The title reaction can be carried out either under conditions A) or under a modified variant if the nitrogen of the starting benzamides (syntheses described) bears an alkyl group instead of ‐O‐Me (reaction mechanism).
ChemInform Abstract: Stereoselective Synthesis of Organosulfur Compounds Incorporating N‐Aromatic Heterocyclic Motifs and Quaternary Carbon Centers via a Sulfa‐Michael Triggered Tandem Reaction.
Authors: Qin Tianyou , Cheng Lu , Zhang Sean Xiao‐An , Liao Weiwei
Published: September 2015

A novel sulfa‐Michael addition (SMA)‐triggered tandem reaction is developed by combining a SMA reaction with a simultaneous rearomatization process utilizing a less reactive carbonyl group as an intramolecular electrophilic partner.
ChemInform Abstract: The Reaction of 6‐Substituted 4‐Pyrone‐2‐carboxylic Acids with O‐Phenylenediamine. Synthesis and Structure of 3‐(1H‐1,5‐Benzodiazepin‐2(3H)‐ylidenemethyl)quinoxalin‐2(1H)‐ones.
Authors: Obydennov Dmitrii L. , Sosnovskikh Vyacheslav Ya.
Published: September 2015

The reactions of 4‐pyrone‐2‐carboxylic acid derivatives (I), (V), (X), and (XIII) with o‐phenylenediamine (II) or 2‐aminophenol (VIII) are described.
ChemInform Abstract: Ruthenium‐Catalyzed Silylation of 1,3‐Butadienes with Vinylsilanes
Authors: Szudkowska‐Fratczak Justyna , Marciniec Bogdan , Hreczycho Grzegorz , Kubicki Maciej , Pawluc Piotr
Published: September 2015

leading to (E,E)‐dienylsilanes (III) as main products
ChemInform Abstract: Pd‐Catalyzed Carbonylative Access to Aroyl Phosphonates from (Hetero)aryl Bromides.
Authors: Lian Zhong , Yin Hongfei , Friis Stig D. , Skrydstrup Troels
Published: September 2015

This is the first transition‐metal catalyzed carbonylation with a phosphorus nucleophile.
ChemInform Abstract: Trapping Hemiacetals with Phosphono Substituted Palladium π‐Allyl Complexes for the Synthesis of Substituted Cyclic Ethers.
Authors: Sutivisedsak Nongnuch , Dawadi Surendra , Spilling Christopher D.
Published: September 2015

It is demonstrated, that hemiacetals or hydrates derived from aldehydes (I) and methanol or water undergo Pd‐catalyzed intramolecular trapping to form cyclic acetals (III) and (V).
ChemInform Abstract: Resveratrol‐Based Benzoselenophenes with an Enhanced Antioxidant and Chain Breaking Capacity.
Authors: Tanini Damiano , Panzella Lucia , Amorati Riccardo , Capperucci Antonella , Pizzo Elio , Napolitano Alessandra , Menichetti Stefano , d'Ischia Marco
Published: September 2015

A novel class of resveratrol derivatives is obtained in good yields by direct selenenylation of resveratrol with Se(0) and SO2Cl2 in dry THF.
ChemInform Abstract: Two Novel Antiviral Terpenoids from the Cultured Perovskia atriplicifolia.
Authors: Jiang Zhi‐Yong , Zhou Jun , Huang Chao‐Guan , Hu Qiu‐Fen , Huang Xiang‐Zhong , Wang Wei , Zhang Li‐Zhu , Li Gan‐Peng , Xia Fu‐Ting
Published: September 2015

Isolation and structural elucidation of norperovskatone (I) and biperovskatone (II) are described.
ChemInform Abstract: Two Homosecoiridoids from the Flower Buds of Lonicera japonica
Authors: Song Wei‐Xia , Guo Qing‐Lan , Yang Yong‐Chun , Shi Jian‐Gong
Published: September 2015

isolation and structure elucidation of loniaceticiridoside (I) and lonimalondialiridoside (II)
ChemInform Abstract: Taraxastane‐Type Triterpene Saponins Isolated from Pittosporum angustifolium Lodd.
Authors: Baecker Christian , Jenett‐Siems Kristina , Siems Karsten , Niedermeyer Timo H. J. , Wurster Martina , Bodtke Anja , Lindequist Ulrike
Published: September 2015

Two new taraxastane‐type triterpene saponins, named pittangretoside L (I) and C1 (II), are isolated from the leaves of Pittosporum angustifolium.
ChemInform Abstract: Polyoxygenated Dihydropyrano[2,3‐c]pyrrole‐4,5‐dione Derivatives from the Marine Mangrove‐Derived Endophytic Fungus Penicillium brocae MA‐231 and Their Antimicrobial Activity
Authors: Meng Ling‐Hong , Li Xiao‐Ming , Liu Yang , Wang Bin‐Gui
Published: September 2015

isolation and structure elucidation of pyranonigrin F (I)
ChemInform Abstract: Synthesis of Marine Brominated Alkaloid Amathamide F: A Palladium‐Catalyzed Enamide Synthesis.
Authors: Ahmad Saeed , Choudhury Sumit , Khan Faiz Ahmed
Published: September 2015

The total synthesis requires only 4 steps from easily accessible starting material.
ChemInform Abstract: Construction of 9,10‐syn—trans‐Decalin Skeleton via Semipinacol Rearrangement: Asymmetric Synthesis of (+)‐syn‐Copalol and a Candelalide Analogue.
Authors: Li Zhongliang , Yang Dan
Published: September 2015

(+)‐syn‐Copalol (I) and its analogue (II) are prepared from (+)‐sclareolide.
ChemInform Abstract: Flavonoids from the Leaves of Sun Cured Tobacco and Their anti‐Tobacco Mosaic Virus Activity.
Authors: Yang Guang‐Yu , Miao Ming‐Ming , Wang Yun , Liu Chun‐Bo , Shen Qin‐Peng , Zhang Feng‐Mei , He Pei , Liu Zhi‐Hua , Zhang Hong‐Bin , Yang Xiao‐Dong
Published: September 2015

From the leaves of Yunnan local sun cured tobacco, two new flavonoids, 4′,6‐dihydroxy‐7,8‐dimethoxyisoflavone (I), and 8‐acetyl‐4′‐hydroxy‐7‐methoxy‐6‐methylflavone (II), together with four known flavonoids are isolated and their structures determined by NMR spectroscopic studies.