bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and validation of prognostic nomograms for adult patients with papillary renal cell carcinoma (PRCC): A Retrospective Study
Authors: Guo Qingxiang , Li Shuaishuai , Zhu Jiawei , Wang Zewei , Jiang Lei , Li Zhen , Wang Junqi , Wen Rumin , Li Hailong
Published: February 2023

Objective
Creating two consensus nomograms for predicting overall survival (OS) and cancer-specific survival (CSS) in adult patients with papillary renal cell carcinoma was the aim of this study (pRCC).
Method
Using the Surveillance, Epidemiology, and End Results (SEER) database, a retrospective analysis of 1074 adult patients with pRCC from 2004 to 2015 was performed. These patients were then randomly divided into two independent cohorts with a ratio of 7:3 (training cohort: 752, validation cohort: 322). In a retrospective analysis of 752 patients from the training cohort, independent prognostic variables affecting OS and CSS were found. R software was used to create prognostic nomograms based on the findings of Cox regression analysis. The performance of the nomograms was assessed using the C-index, AUC curves, calibration curves, and DCA curves. Data from the 107 postoperative pRCC patients at the Affiliated Hospital of Xuzhou Medical University were used to externally validate the nomogram.
Results
For OS and CSS, the C-indices and AUCs of the training cohort and the validation cohort indicated that the model had excellent discrimination. The DCA curves demonstrate that the model is clinically applicable. The calibration curves in internal and external validation showed that the model's accuracy was high.
Conclusion
In the current study, we developed and validated a prognostic nomogram that accurately predicts the 3-, 5-, and 8-year OS and CSS of adult patients with pRCC. Clinicians can use this knowledge to direct the clinical management and counseling of patients with pRCC.
As(III)-oxidizing bacteria alleviate arsenite toxicity via reducing As accumulation, elevating antioxidative activities and modulating ionome in rice (Oryza sativa L.)
Authors: Lin Guobing , He Xiaoman , Zeng Jiayuan , Tang Jie , Wang Lin
Published: February 2023

Compared to other crops, paddy rice trends to accumulate more arsenic (As) from soils. The toxicity and mobility of As mainly depended on its chemical species. To mitigate As(III) stress to rice plants, As(III)-oxidizing strain SMS11 isolated from As-contaminated soils was employed in the current study. The rice seedlings were hydroponically cultivated in three groups: Control Group (without any addition), As(III) group (amended with 1 mg∙L-1 As(III)) and As(III)+B group (treated with As(III) and As(III)-oxidizing bacteria). Compared to Control group, the growth of rice shoots from As(III) group was significantly restricted. Inoculation with the bacteria could not only enhance the growth of the rice plants, but also significantly reduce the As level in the rice shoots. Evaluation of oxidative stress indices showed that superoxide dismutase activity in the rice plants was enhanced under As(III) stress, resulting in promoted inhibition ability of superoxide anion radical (O2•−). The activity of catalase in the rice shoots was weakened when exposed to As(III), increasing the risk of hydroxyl radical (•OH) formation. When co-cultivated with the bacteria, •OH formation was significantly inhibited in the rice shoots. Uptake of As elevated most nutrient element contents in the rice shoots simultaneously. The levels of most nutrient elements in the rice shoots were declined with alleviation of As stress after inoculation with the bacteria. The ionomics of the rice plants revealed significant variations with tissues and environmental conditions. The results represented ionomic profile as a promising tool to identify rice plants under different external conditions.
The Experiences of Online Students with Permanent Acquired Memory Related Issues: A qualitative study
Authors: Moore Justine E , Garip Gulcan
Published: February 2023

Higher education institutions within the United Kingdom have been making efforts to reduce the educational disparity that occurs between abled students and those with learning disabilities. Students with learning disabilities are more likely to abandon their studies than their able counterparts. However, given the unprecedented shift to online learning during the Covid − 19 pandemic, it is likely that those with learning disabilities have faced new challenges. Within psychology research into online learning, one population that has received little attention is students with permanent acquired memory-related issues. Therefore, this qualitative interpretative phenomenological analysis study explores the student experience of six mature university students who started online learning before Covid-19 to understand (i) what online learning means for students with permanent acquired memory related issues and (ii) what barriers and facilitators they encountered within their academic journey. Three themes were developed (i) Negotiating the challenges of online learning (ii) Online learning and the emotional experience, and (iii) Avoiding the gaps presented by online learning. The findings suggest that students’ online experience with permanent acquired memory loss was complex. Academic staff’s misunderstanding and the impact of Covid-19 combined to create several challenges, but support and individualised strategies aided course adherence.
Health expectancy in Russia in 1998-2022
Authors: Ramonov Alexander
Published: February 2023

Background:
The aim of this research is to estimate the scenarios of health expectancy dynamics following life expectancy dynamics
Methods:
Life tables including the information on health self-assessment.
Results:
From 2004 to 2019 the value of e(20)-h(20) for males increased from 4.5 years to 5.5 years (%e(20) remained constant on the level of 11%).
For females e(20)-h(20) decreased from 10.8 to 7.5 years (%e(20) decreased by 7% - from 20% to 13%).
Conclusion:
The positive dynamics of general health among females in Russia may be associated with a decrease in mortality from cardiovascular diseases among the elderly, which, combined with the positive dynamics of self-protective behavior, could show signs of the “cardiovascular revolution”.
Additional explanatory mechanism for this hypothesis is proposed.
Employability of Young Graduates in Togo
Authors: AMENOUDJI Ahoéfa Améyo , Wonyra Kwami Ossadzifo
Published: February 2023

This paper examines the factors influencing the employability of young graduates in Togo. The results obtained from econometric estimations using a binary Logit model reveal that the age range of 25–35 years and the married status positively affect the employability of young graduates of both sexes. In addition, being the head of the household is more motivating to seek work. On the other hand, the results suggest that women are less likely to get a job than their male counterparts. In addition, a high level of education decreases the chances of getting a job. Conversely, apart from Lomé, other urban centres negatively affect the employability of young graduates. Additional results also show that youth with disabilities have a low probability of finding employment. Multinomial logit estimates reveal that youth aged 25–35 in Togo choose the primary sector less than other sectors. Young women are more likely to be employed in the secondary sector.
Trends of Tropical Cyclone Parameters
Authors: Swedan Nabil
Published: February 2023

Tropical cyclones are seasonal phenomena that have to be calculated annually. The annual sea temperature rise in the tropics is small, of the order of 0.0018°C or less, and detecting mathematically significant trends of tropical cyclone parameters using Carnot cycle representation does not appear to be practically possible. The size of tropical cyclones is massive, and minute calculation errors spread large enough to overshadow the trends of the parameters. However, most of tropical cyclone structure may be determined by equations of classical mechanics, which are well defined and exact. This may reduce the calculation errors and mathematically significant and valid trends of tropical cyclone parameters determined. Accordingly, for equal temperature difference between sea water and air, the ocean heat flux required for tropical cyclone genesis decreases with latitude. Because sea temperature rise increases with latitude, tropical cyclones have been shifting their nascent locations farther away from the equator. Therefore, for the same annual energy available to tropical cyclones, the number of tropical cyclones increases with time. The increase is nearly equal to 4.08% ±0.76% per decade. Tropical cyclone intensity does not appear to be impacted by surface warming. The methodology provided may be used to assess trends of virtually all tropical cyclone parameters.
Hacking Inequality
Authors: Verständig Dan , Stricker Janne
Published: February 2023

Der planvolle Umgang mit digitalen Technologien kann als eine zentrale Herausforderung in medien- und schulpädagogischen Handlungsfeldern gesehen werden. Dabei ist weitestgehend offen, welche Bedeutung Partizipation und Teilhabe im Hinblick auf den digitalen Wandel haben und wie sie sich konkret umsetzen lassen. Der Beitrag will ausgehend vom Begriff des Hackings eine Perspektive auf digitale Ungleichheit und mediale Praktiken entwickeln, bei der kreative Ansätze im Umgang mit digitalen Technologien im Vordergrund stehen. Hacking meint dabei die unkonventionelle Lösung von Problemen. Die These lautet, dass eine nachhaltige Gestaltung von formalen Lern- und Bildungssettings in der digitalen Welt vor allem dadurch erfolgen kann, dass Schule im Horizont der Digitalität neu erdacht und damit sprichwörtlich gehackt wird.
A Comparison of Two Media Formulations and Two Vented Culture Vessels for Shoot Multiplication and Rooting of Hemp Shoot Tip Cultures
Authors: Borbas Lillian N. , Kurtz Lauren E. , Lubell-Brand Jessica D.
Published: February 2023

Micropropagation of hemp (Cannabis sativa) is constrained by problems with hyperhydricity and culture decline of microshoots. These problems can be reduced by increasing agar and nutrients in the media during micropropagation stages 1 and 2, respectfully. Performance of microshoots of ‘Abacus’ and ‘Wife’ hemp cultured in Driver and Kuniyuki Walnut medium (DKW) for 15 weeks (6 weeks of stage 1 + 9 weeks of stage 2), with subculturing every 3 weeks during both stages 1 and 2, or in Murashige and Skoog with vitamins medium (MS) for 6 weeks (stage 1) followed by Lubell-Brand Cannabis medium (LBC) for 9 weeks (stage 2), with subculturing every 3 weeks during both stages 1 and 2, was evaluated. In a separate study, microshoot performance of ‘Abacus’ and ‘Wife’ in MS for 3 weeks (stage 1) followed by LBC for 6 weeks (stage 2), with subculturing every 3 weeks, using boxes (Magenta GA-7) with lids featuring a vent with a diameter of 10 mm and a pore size of 0.2 µM or using microboxes (Sac O2 O95/114 + OD95) with lids featuring a filter (Sac O2 #10) were evaluated. Shoot multiplication rate (SMR) and explant height were greater for ‘Abacus’ in LBC than DKW. For ‘Wife’, SMR at 9 weeks was greater in LBC, as LBC provided more nutrients and water than cultures had received in MS initially during stage 1. Culture medium did not influence ex vitro rooting success, which was 75% for ‘Abacus’ and ≥ 90% for ‘Wife’. Microboxes resulted in greater hyperhydricity of shoots and a lower ex vitro rooting percentage than boxes. For cultivars that are highly prone to developing hyperhydricity, like ‘Abacus’, the microboxes were not adequate to control this condition.
Humpuukia ja hulluutta: Uuden taiteen vastaanotto 1910-luvun Suomessa
Authors: Siukonen Jyrki
Published: February 2023

Humbuggery and madness. The reception of new art in the 1910s in Finland If the artworld is a battlefield of meanings, the fortunes of discourse did not favour avant-garde art in Finland in the 1910s. The latest trends, introduced by German and Russian artists in three pioneering exhibitions in Helsinki in 1914 and 1916, were dismissed by the Finnish press as foolish and unworthy. This book researches the contemporary reactions and contents of these exhibitions. The works shown in Helsinki included masterpieces from artists such as Chagall, Jawlensky, Kandinsky, Marc, Münter and Rozanova. Today these works can be found in the collections of leading museums in Europe, Russia and the USA. From the Finnish perspective, the turndown in the 1910s proved effective and irreversible. Never again have the local collections had similar opportunities to make a purchase. The rejection of radical international developments and emphasis on narrow nationalistic views left Finnish art lagging behind. This trend was already apparent in 1917 in St. Petersburg, where the Finnish artists were celebrated but their paintings deemed sombre and superannuated.
INDUCTION OF LABOR AND ITS FETOMATERNAL OUTCOME
Authors:   Post Graduate, Department of Obstetrics & Gynaecology, Victoria Government Hospital for Women & Children, Andhra Medical College, Visakhaptnam, Andhra Pradesh, India., Hima Madhuri Doddipatla , Dali Naga Swetha Ravi ,   Assistant Professor, Department of Obstetrics & Gynaecology, Victoria Government Hospital for Women & Children, Andhra Medical College, Visakhaptnam, Andhra Pradesh, India., Soumini Gangaraju ,   Professor, Department of Obstetrics & Gynaecology, Victoria Government Hospital for Women & Children, Andhra Medical College, Visakhaptnam, Andhra Pradesh, India., Prasad Usha ,   Professor, Department of Obstetrics & Gynaecology, Victoria Government Hospital for Women & Children, Andhra Medical College, Visakhaptnam, Andhra Pradesh, India.
Published: February 2023

Induction of labor is opted for benefits of expeditious delivery to outweigh the risks of continuing the pregnancy. Aims and Objectives: To study the indications and methods of induction of labor & to correlate Feto-Maternal outcome. Materials & Methods: The present study was conducted on 150 pregnant women. It is a prospective observational study, conducted from April 2021 to September 2021. Patient details with Indication, examination, pre-induction Modified Bishops score, Partogram, were noted of 150 pregnant women and the results were analyzed. Electronic fetal heart rate monitoring was done in all except Intra-uterine Fetal Demise (IUFD) cases. Methods used were Dinoprostone, misoprostol, mechanical dilatation using foleys catheter single or in combination with each other. SPSS version 23.0 was used for statistical analysis, statistical significance was set as p<0.05. Result: Common indications for induction were Past-dated pregnancy, followed by Gestational- Hypertensive disorders, Oligoamnios, Pre-labor rupture of membranes respectively. Among the 150 mothers, 113(75.3%) delivered vaginally and 37(24.6%) underwent LSCS. Dinoprostone gel was the dominant method used. Mechanical dilatation with Dinoprostone for induction of labor had a better outcome and less rate of failed induction. 4 mothers in this study were diagnosed with IUFD and induced with Mechanical Dilatation followed by Dinoprostone, all delivered vaginally. NICU admissions were required in 21.7%, 25%, 22% of the mothers who were induced with Dinoprostone, Misoprostol and Mechanical Dilatation respectively. Conclusion: Most common indication for induction is Past dated pregnancy. Most common method used is Dinoprostone alone. Perinatal Morbidity was more with Misoprostol. No maternal and Perinatal mortality.
BARRIERS AND PROSPECTS FOR CREATING HEALTHY MEAT SNACKS
Authors: Patshina Marina , Bryanceva N. E. , Puzyrnikova A. I.
Published: February 2023

The spread of alimentary-dependent diseases can be considered a national threat. The lack of
prevention often leads to mortality and disability in Russia and the world. The promotion of a healthy
lifestyle is gaining a global scale in the formation of a healthy society. Food producers in general and
meat processing enterprises in particular play a key role in solving this problem. The vectordetermining trajectory of the development of the market of meat products for healthy nutrition is the
presence of consumers, demand and niche. Today, the market of "healthy" meat snacks is developing
and promising. Identifying development barriers and insights will allow businesses to occupy a niche
and gain a market advantage.
EDITING OF THE HUMAN GENOME – LEGAL ASPECTS OF CLINICAL APPLICATION
Authors: Pestrikova A. A.
Published: February 2023

The relevance of the study is determined by the need to take into account the risks
of editing the human genome (somatic, embryonic and inherited editing of the human genome), the
possibilities of introducing human genome editing into clinical practice. Editing of the human
genome (somatic, germinal and inherited editing of the human genome) has significant potential for
humanity and health systems, medicine and science. At the same time, editing of the human genome
requires studying the risks and advantages of such editing for the formation of legal regulation.
DEVELOPMENT OF TECHNOLOGIES FOR CURD FOOD SYSTEMS BASED ON PLANT BIOCORRECTORS
Authors: Pozhidaeva Ekaterina , Golubeva Lyubov , Boeva Yu. O.
Published: February 2023

The objects of experimental studies were curd products of m.d.zh. 5% without including and
without bioactive composition based on flour from seeds of sesame seeds, pumpkin and walnuts in
the amount of 20%. Based on the analysis of experimental data obtained using an odor analyzer
(«electronic nose»), it was revealed that, in terms of the quantitative and qualitative composition of
the equilibrium gas phase, the degree of identity of the control and experimental samples is more than 85%. It has been established that the prototype is characterized by the predominance of
traditional organoleptic indicators corresponding to curd products.
DEVELOPMENT OF HEALTH-SAVING BIOTECHNOLOGIES OF SPECIALIZED PRODUCTS: PARADIGMS OF PRIORITY SOLUTIONS
Authors: Poznyakovskiy Valeriy , Vekovtsev Andrey , Gorbushina I. S.
Published: February 2023

A health-saving biotechnology of a specialized product has been developed using the
technology of obtaining carrot cells with the intestinal alkaline phosphatase genome, based on the
cultivation of transformed carrot cells (somatic embioids) in suspension culture with further freezedrying. The probiotic product is intended for the correction and complex treatment of disorders of
the intestinal microflora and the immune system, prevention of the development of autoimmune and
inflammatory diseases. The mechanism of this action is to prevent the activity of LPS, NF – Kb,
TLRY receptors and, as a consequence, the expression of anti-inflammatory cytokines. The data of
the target segment and the volume of their production are presented. Recombinant human intestinal
alkaline phosphatase (cSF) was obtained in vitro from carrot cells, which is the novelty and
originality of technological solutions. In this case, the plant cell acts as an ideal means of delivering SF to the target cells of the intestine. At the same time, it is stable in the acidic environment of the
stomach and is promptly destroyed in the intestine by microflora enzymes. The product has been
tested on the basis of the biotech cluster of the Art Life company (Tomsk) according to the
requirements of the 22,000 series and GMP standards, providing confidence in the stability of the
specified quality and safety characteristics.
DESIGN OF COMPLEX FOOD SUPPLEMENTS BASED ON POLYPHENOL COMPOUNDS OBTAINED FROM CALLUS CULTURES VACCINIUM VITIS-IDAEA IN VITRO METHOD
Authors: Popov V. G. , Aksent'eva V. V.
Published: February 2023

Development of complex food additives based on valuable Arctic plant raw materials obtained
by in vitro callusogenesis, producing polyphenolic compounds. The process under consideration makes
it possible to obtain high-quality phenolic compounds in sufficient quantity with the lowest economic
costs in comparison with the traditional plantation method.
NUMERICAL SIMULATION OF THE OPERATION OF THE APPARATUS FOR THE HEAT TREATMENT OF DAIRY RAW MATERIALS WITH INDUCTION HEATING
Authors: Porohnov A. N. , Milentyeva Irina
Published: February 2023

This work is devoted to the development of algorithms for numerical simulation of the
processes of heat treatment of raw milk using induction heating. Such studies will help determine
the thermal effect of the process, the characteristics of the quality and safety of the resulting product
based on dairy raw materials.
A CASE OF PREIMPLANTATION GENETIC TESTING FOR A COUPLE IN WHICH BOTH SPOUSES ARE CARRIERS OF AUTOSOMAL RECIPROCAL TRANSLOCATIONS
Authors: Puppo I. L. , Tonyan Z. N. , Sayfitdinova A. F.
Published: February 2023

The paper presents the results of the preimplantation genetic testing for a couple in which both
spouses are carriers of balanced autosomal translocations. The chromosome segregation pattern and
individual characteristics of quadrivalents for both rearrangements were determined, and the risk of
reproductive problems in a offspring who inherited a maternal translocation was assessed.
THE PERSONALIZED TECHNOLOGY OF CANCER TREATMENT "KARANAHAN" HAS THREE VECTORS OF THERAPEUTIC EFFECT
Authors: Ruzanova V. S.
Published: February 2023

The aim of this work was to test the technology of treatment of malignant tumors
"Karanahan" on the Lewis lung carcinoma model and to prove the existence of the third antitumor
therapeutic vector of this technology – activation of antitumor immunity.
FUNCTIONAL BREAD MADE USING RYE FLOUR AND INNOVATIVE INGREDIENTS BASED ON SPROUTED RYE GRAIN
Authors: Savkina O. A. , Kostyuchenko M. N. , Kuznecova L. I. , Burykina M. S.
Published: February 2023

The development of the production of bakery products for specialized and functional
purposes, enriched with irreplaceable components that allow changing bread as a nutritional
element, is a priority for the baking industry. The aim of the work was to study the nutrition
values of bread made using rye flour and an innovative ingredient based on sprooted rye. It was
shown that bread made using rye flour, as well as products based on sprouted rye, is a source of
essential elements and it can be classified as food additives.
DEVELOPMENT OF DAIRY DRINK TECHNOLOGY BASED ON RECONSTITURED SYSTEMS «MILK POWDER – WHEY POWDER» ENRICHED WITH GINGER ROOT
Authors: Salmanova D. A. , Evdokimov Ivan , Lodygin Aleksei
Published: February 2023

The relevance of the cavitation disintegration method application for the reconstitution of dry
dairy products is substantiated. The results of research on the creation of a milk drink based on the
systems «milk powder – whey powder» restored using ultrasonic cavitation are presented. The
technology and formulation of an enriched milk drink with the addition of ground ginger root have been
developed.
JUSTIFICATION OF THE FEASIBILITY OF USING A NEW BIODEGRADABLE PACKAGING FOR FOOD
Authors: Semuhin A. S. , Zavorohina N. V.
Published: February 2023

This article substantiates the expediency of using packaging made of environmentally
friendly biodegradable materials instead of traditional plastic packaging based on petroleum
polymers because of analysis of the current state of packaging use in the Russian consumer market
and an assessment of environmental awareness of Yekaterinburg residents regarding the production
and use of biodegradable packaging.
STUDY OF THE EFFECT OF IMITATION BACON ON THE QUALITY INDICATORS OF SEMI-SMOKED SAUSAGES
Authors: Seregin Sergey
Published: February 2023

Objective: the paper studies the qualitative characteristics and functional properties of
thermostable emulsions (imitation bacon) of various compositions, assesses the effect of the level of
application of imitation bacon on the chemical composition and consumer characteristics of semismoked sausages
FUTURE DIRECTIONS OF VEGETABLE RAW MATERIAL PROCESSING FOR EXTRACTION OF PHYTOCHEMICAL COMPOUNDS FOR FOOD SYSTEMS
Authors: Starovoitova Kseniya , Tereshchuk Lyubov , Sergeeva Irina
Published: February 2023

A team of scientists from the Department of Food Technology from Plant Raw Materials
conducts a set of studies aimed at finding ways to extract phytochemical compounds to create
functional food systems. Laboratory methods have been developed for the extraction of watersoluble and fat-soluble biologically active substances from plant raw materials (tocopherols,
carotenoids and phospholipids). Supercritical liquid extraction was chosen as the most suitable
method to replace organic solvent extraction protocols. In order to develop laboratory methods for
extracting flavonoids, as well as methods adapted to industrial conditions, the following vegetable
raw materials were chosen: as a source of apigenin - parsley, luteolin and genistein - lupin,
isoramnetin - sea buckthorn berries, cyanidine and petunidine - chokeberry, flavons, flavanones,
flavanonols - root dandelion.
METHOD FOR IMPROVING ORGANOLEPTIC PROPERTIES OF A DRINK BASED ON MEDUSOMYCES GISEVII CULTURE BY ADDING PINE CONES DECOAT
Authors: Stepanova A. A. , Asyakina Lyudmila , Proskuryakova Larisa
Published: February 2023

The article discusses a method for increasing the organoleptic component of a tea fungus
drink by adding a decoction of pine cones, and a method for cultivating Medusomyces gisevii on
a nutrient medium. The results of evaluating the quality of the cultural liquid of kombucha
according to organoleptic indicators are given: appearance, color, taste and smell.
THE LEVEL OF CHROMOSOMAL ABERRATIONS AND THE DOSE OF ACTIVE RIBOSOMAL GENES IN COAL MINE WORKERS
Authors: Timofeeva A. A. , Soboleva O. A. , Astaf'eva E. A.
Published: February 2023

Purpose: to study the relationship between the dose of active ribosomal genes and the level of
chromosomal aberrations in coal mine workers.
Chromosomal aberrations were studied in 357 miners and 736 men who do not work at
industry. The dose of active ribosomal assessed in 154 miners and 91 people from the comparison
group. Identified increase in the frequency of occurrence of single fragments in workers with an
average dose of active ribosomal genes.
THE ROLE OF ADPRT 2285 A>G rs1136410 GENE POLIMORPHISM IN THE FORMING OF SUSCEPTIBILITY TO THE DEVELOPMENT OF BREAST CANCER
Authors: Torgunakova A.V. , Minina V.I. , Soboleva O. A. , Neverova Olga
Published: February 2023

Breast cancer (BC), with nearly 1.7 million incidence and 522,000 deaths (according to
GLOBOCAN statistics), is the most frequently occurring cancer in women. The etiology of BC is
multifactorial and has not been fully elucidated. However, genetic factors are known to increase or
decrease susceptibility to BC, suggesting that genetic polymorphisms play an important role in the
oncopathology.
Accordingly to these facts, the aim of our study was the analysis of polymorphic variants of
DNA repair genes ADPRT 2285 A>G rs113641 in BC patients and conditionally healthy women of
Kemerovo region.
STUDY OF THE STORAGE OF BAS ENCAPSULATED IN EMULSION FOOD SYSTEMS
Authors: Feofilaktova O. V.
Published: February 2023

The article presents the results of a comparative analysis of the persistence of biologically
active substances on the example of vitamins B1 and E, encapsulated in the matrix core of double
emulsion food systems, in the aqueous phase of the direct and fatty phase of the reverse emulsion
food systems. According to the results of the research, the efficiency of vitamin encapsulation in
double emulsion systems was established to increase their shelf life: at the end of storage, the residual content of vitamin B1 in the double emulsion system water-oil-water was 34% higher than
its content in the inverse emulsion, and the content of vitamin E in the emulsion system oil-wateroil at the end of the storage period was 24% more than in direct emulsion.
MODERN ASPECTS OF THE USE OF BIOLOGICALLY ACTIVE ADDITIVES
Authors: Bikbulatov P.S. , Arisov A.V.
Published: February 2023

In the modern market, manufacturers are widely represented, providing a large selection of
biologically active additives that help to fill various deficits. In this regard, the study of the main criteria
for the production, certification, quality control of biologically active additives allows us to study this
market in more detail and find new opportunities for the development and provision of new and modern
production technologies to consumers.
PROSPECTS FOR THE USE OF VITAMIN D IN FOOD SYSTEMS
Authors: Chugunova Olga , Dyldin D. V. , Shkolnikova Marina
Published: February 2023

The features of the use of vitamin D in food systems, the choice of the most
effective forms and methods of vitamin D use are considered. It is shown that the
bioavailability of vitamin D2 varies depending on the products, while vitamin D3 is
bioavailable from many products.
POPYMORPHISM OF IMMUNE RESPONSE GENES AND LUNG CANCER RISK IN NON-SMOKING RESIDENTS OF KUZBASS
Authors: Buslaev V.Yu. , Torgunakova A.V. , Milentyeva Irina , Dyshlyuk Lyubov , Minina V.I.
Published: February 2023

Lung cancer (LC) is leading oncological pathology, posing a serious threat for patient’s lives.
Accordingly to World Health Organization (WHO) 2,1 million of new cases and 1,8 of deaths are
annually registered. It was accumulated a lot of information about significant influence of smoking on
increased risk of LC development. 80-90% of patients with LC are namely smokers. However at present
time it was registered increased level of mortality from this pathology among non-smoking patients [1].
LC formation in non-smoking individuals can occur due to environmental pollution by industrial and
household cancerogens and also because of molecular and genetical and cytogenetical dissimilarities.
Since LC development can be associated with anomalous immunological response, immune genes can
be considered as potential biological markers [2].
Objective: To assess the influence of polymorphic variants of innate immunity genes on LC
development in non-smoking patients.
PREPARATION OF GALACTOOLIGOSACCHARIDES USING HYPERTHERMOPHILIC ΒGALACTOSIDASE IN PERMEABILIZED WHOLE CELLS OF LACTOCOCCUS LACTIS
Authors: Buyanova Irina , Elistratova D.A.
Published: February 2023

Purpose: The current state and prospects of the production of functional nutrition products are
analyzed. Analysis of the conducted research to develop a convenient and cost-effective method for
obtaining food products enriched with galactooligosaccharides.
TECHNOLOGICAL FEATURES OF PLANT MILK PRODUCTION
Authors: Vasil'ev K. I. , Korotkaya Elena
Published: February 2023

Objective: investigation the influence of the type of plant materials on the technological
features of the production of plant milk
ION CHROMATOGRAPHY AND ITS APPLICATIONS IN DISTILLED BEVERAGES QUALITY CONTROL
Authors: Abramova I. M. , Medrish M. E. , Savel'eva V. B. , Romanova A. G. , Matrosova N. V.
Published: February 2023

This work describes the ionic composition studies of several distilled alcoholic beverages by ion chromatography with conductometric detection. Typical mass concentrations ranges for cations and anions have been established. Microelement migration from filter cardboard used in alcoholic beverage production has been researched. Introducing the described express methods into the quality control system for alcoholic beverages obtained from herbal raw materials will make it possible to control the critical points in their production, thereby timely eliminating the drinks quality deterioration causes.
INTEGRATED PROGRAM FOR PREDICTION OF THE RISK OF LUNG CANCER DEVELOPMENT IN WORKING COAL MINES OF KUZBASS
Authors: Vasil'ev N. A. , Stepanov Yu. A. , Bakanova M. L. , Minina V.I.
Published: February 2023

Polymorphic variants of genes of 214 miners of coal mines in Kuzbass in lung cancer
patients, and 300 men of the control group were analyzed. A computer program has been
developed for predicting the risk of developing lung cancer in the working coal mines of
Kuzbass.
Objective: to develop a comprehensive program for predicting the risk of developing
lung cancer in coal mine workers in Kuzbass.
FUNCTIONAL COTTAGE CHEESE PRODUCT WITH THE ADDITION OF CARROTS
Authors: Vorob’eva Ekaterina , Asyakina Lyudmila , Pereverzeva M. K. , Serazetdinova Yu. R. , Emel'yanenko V. P.
Published: February 2023

Currently, due to poor nutrition, people are increasingly suffering from non-communicable diseases. Curd mass helps to reduce the risk of diseases of the gastrointestinal tract due to lactic acid bacteria contained in the product (natural intestinal microflora). Carrots, thanks to dietary fibers, vitamins and macro- and microelements, reduce the possibility of cardiovascular diseases. Thus, curd mass with carrot puree is a functional product aimed at reducing the occurrence of non–communicable diseases.
RELEVANCE OF THE DEVELOPMENT OF INTEGRATED RESOURCE-SAVING TECHNOLOGY FOR THE PRODUCTION OF GELATIN AND HIGH-PROTEIN INGREDIENTS FROM SECONDARY RAW MATERIAL RESOURCES OF ANIMAL ORIGIN
Authors: Voroshilin Roman , Mahambetov E. M. , Kostel'ceva Yu. A. , Golovko K. K. , Maklyuk V. V.
Published: February 2023

The article presents the main production problems in the production of edible gelatin. ways of optimizing the technological operations of demineralization, liming, deashing of bone raw materials, concentration and drying of gelatin broths are proposed.
GENOME-WIDE ANALYSIS OF A TRIPLE NEGATIVE BREAST TUMORS
Authors: Gaptulbarova K.A. , Cyganov M. M. , Litvyakov N. V. , Ibragimova M. K.
Published: February 2023

Today, breast cancer (BC) is not only a heterogeneous solid malignant neoplasm, but also a heterogeneous disease in terms of prognosis and sensitivity to anticancer therapy. The search for markers to predict the course of the disease and an approach to prevent recurrence and metastasis is of great importance for improving the survival of patients with triple-negative type (TN) breast cancer. Therefore, the aim of the work was to conduct a genome-wide analysis of a breast tumor with a TNBC.
METHOD FOR PRODUCING DIETARY CUTLETS WITH DIETARY FIBERS
Authors: Absalimova M.A. , Baybolova L.K. , Taeva A.M. , Glotova I.A.
Published: February 2023

Soy minced okara was used for the targeted enrichment of minced meat semi-finished
products with dietary fibers (DF). Additionally, it is a source of high-grade protein in amino acid
composition, as well as potassium, calcium, magnesium, phosphorus, iron. Okara was used as a
component of a protein-carbohydrate composition (PCC). Chickpea flour and whey protein
concentrate were used to balance the amino acid composition of beech and correct the functional
and technological properties of food systems
STUDY OF FRACTIONAL COMPOSITION OF PROTEINS OF MILK-PROTEIN CONCENTRATES
Authors: Gutov N
Published: February 2023

Purpose: to study the fractions of casein proteins and whey proteins with reference to their molecular weight values. Consider the nature of microfiltration and diafiltration processes actively accepted in the separation of casein proteins from whey proteins. Describe the process of removing pathogenic microflora from defatted mo-lock using ceramic membranes.
THEORETICAL FOUNDATIONS OF THE DEVELOPMENT OF FLOUR CONFECTIONERY PRODUCTS THAT MEET THE PRINCIPLES OF HEALTHY NUTRITION
Authors: Demchenko Elena , Mizinchikova Inessa
Published: February 2023

Preserving the health and increasing the life expectancy of the population is a priority task of the modern state policy of the Russian Federation. The complexity and multidimensional nature of the task determine the relevance of the development of specialized and functional food products that meet the needs of various population groups in optimal, healthy nutrition, taking into account their traditions, habits and economic situation. The article analyzes the existing regulatory and methodological framework in the field of specialized and functional food products, discusses current problems in the field of its development and production, identifies areas requiring development and offers technological solutions.
SIGNIFICANCE OF CYP2D6 GENE POLYMORPHISM FOR DETERMINING THE RISK OF BREAST CANCER
Authors: Dzhambetova P. M. , Bisultanova Z. I. , Acaeva M. M.
Published: February 2023

Purpose: to identify the role of the polymorphic variant of the CYP2D6*4 gene, as the most common variant among Europeans, in the diagnosis of breast cancer among 240 patients diagnosed with breast cancer and 360 women in the control group of the Chechen population. Quantitative analysis showed that the polymorphic variant CYP2D6 * 4 detection (p=0.005) increased the risk of developing a malignant tumor (OR = 1.65 (95% CI = 1.16 - 2.34). It was shown that in intermediate metabolizers, an ineffective allele breast *4 of the CYP2D6 gene can be a predictor of the development of breast cancer.
FORMATION OF REQUIREMENTS FOR THE COMPOSITION AND PHYSICOCHEMICAL PARAMETERS OF LACTOSE-CONTAINING RAW MATERIALS FOR THE PRODUCTION OF LACTULOSE CONCENTRATES
Authors: Avtandilyan N.G. , Halkechev R.R. , Lodygin Aleksei
Published: February 2023

The relevance of lactulose concentrates development for the production of functional foods
is substantiated. The results of studies of the effect of the amount of an alkaline catalyst of the
isomerization reaction on the physico-chemical parameters of permeates of secondary dairy raw
materials are presented.
STUDYING THE PROSPECTS OF APPLICATION OF MICROGREEN FOR SPECIALIZED NUTRITION
Authors: Zirka A. Yu. , Plastun A. D.
Published: February 2023

The range and popularity of vegetable raw materials is growing, in connection with this, there is a need to study the prospects for the use of new or less popular food products of the "superfood" category for specialized nutrition as a source of essential macro and micro nutrients. The study analyzed the benefits and possible difficulties of using microgreens for specialized nutrition. Microgreens can be a good source of essential nutrients, since they have a wide range of them in their chemical composition, which can be used to form a complete diet. However, to date, the use of microgreens is associated with difficulties, since this category of raw materials of plant origin has been little studied.
THE BASIS OF MOLECULAR GENETIC CLASSIFICATION OF BREAST TUMORS WITH A TRIPLE NEGATIVE PHENOTYPE
Authors: Ibragimova M.K. , Tsyganov M. , Litvyakov N.V.
Published: February 2023

Current knowledge of the genetic heterogeneity of the most aggressive molecular subtype of breast cancer (BC) - triple negative (TN) - has led to promising discoveries in drug treatment, including the use of DNA-damaging agents (platinum drugs and PARP inhibitors) in these tumors, as well as current use of immunotherapy.
Of greatest importance is the ability to prescribe optimal drug treatment regimens to patients with TN in breast cancer, based on knowledge of the molecular genetic characteristics of this subtype of breast cancer, which will ultimately allow achieving high rates of overall and relapse-free survival. Thus, the identification of the molecular genetic phenotype of breast carcinomas is an important prognostic factor of the disease and makes it possible to personalize the treatment of patients.
The purpose of this work was to present a new approach to the molecular genetic classification of TN in breast cancer with predicting the outcome of patients.
EVALUATION OF THE PROSPECTS FOR THE USE OF NUTRIENT PROFILING IN THE DEVELOPMENT OF SPECIALIZED DIETS
Authors: Kalinkina A. O. , Lachugin A. P. , Rozhdestvenskaya L. N.
Published: February 2023

Objective: Demonstrate the need to use a nutritional profiling system in the development of specialized diets.
TECHNOLOGICAL TECHNIQUES AIMED AT PRESERVING THE NUTRITIONAL VALUE OF GRAPE JUICE
Authors: Kiseleva Tatyana , Rabovalyuk D. V.
Published: February 2023

The paper considers the peculiarities of the chemical composition and nutritional value of grapes, special attention is paid to the methods of obtaining grape juice that has stability during storage.
RESEARCH AND DEVELOPMENT OF FROZEN BIODESERT TECHNOLOGY WITH A GIVEN COMPOSITION AND PROPERTIES
Authors: Kolosova E. V. , Moliboga Elena
Published: February 2023

The foundations of the state policy in the field of healthy nutrition and the policy of producers of healthy food products are the preservation and strengthening of public health, prevention of diseases associated with malnutrition of children and adults. The creation of safe and high-quality food products that improve the nutritional status of the population is an urgent task of the food industry. One of the key directions of its solution is connected with the development and introduction of various types of functional food products into the nutrition structure of the Russian population.
The priority direction in the production of ice cream is the production of functional products, using food components and biologically active additives, not only contributing to an increase in the nutritional value of products, but also allowing them to give it the desired therapeutic and preventive properties.
ANALYSIS OF THE SYSTEM OF ORGANIZATION OF SCHOOL MEALS IN THE KEMEROVO MUNICIPAL DISTRICT
Authors: Alymova E.Yu. , Mayurnikova L.A. , Krapiva T.V.
Published: February 2023

The analysis of the system of organization of school meals in the Kemerovo municipal district is
carried out. It is shown that along with the generally accepted ways of optimization, innovations are
widely used in the form of taking into account the climatic and geographical features of Kuzbass, age
categories of schoolchildren, individual characteristics of the body, involvement of the general public in
the process, and the use of digital technologies.
THE USE OF PLANT RAW MATERIALS AS A SOURCE OF RETINOL IN THE PRODUCTION OF SPECIALIZED NUTRITION PRODUCTS
Authors: Kostina Natalya , Grigorieva Roza
Published: February 2023

The development of specialized food products is currently a priority in many sectors of the food industry. The presence of a large number of electronic devices in modern life leads to significant vision problems in the population of different age groups around the world. One of the priority and promising raw materials for maintaining the health of the organs of vision is plant raw materials, used as an enriching component for various food products. Spinach and parsley were chosen as products with a significant content of retinol (vitamin A).
ETHICAL ISSUES OF THE PRACTICAL APPLICATION OF BIOTECHNOLOGY WITHIN LEGAL PROCEEDINGS
Authors: Kruchinina N.V.
Published: February 2023

Scientific achievements in the field of biotechnology promote higher standards of human life, improve its quality, revealing new opportunities in all spheres of human activities.
Moreover, biotechnology is very helpful in checking whether each evidence is quite reliable in legal proceedings, both civil and criminal. The article points out that, at the same time, achievements of biotechnology entail moral problems, as well as criminal risks. It is stated that it is necessary to consider the problems of biotechnological applications within legal proceedings under the optics of morality and of family values.
CHANGES VIABILITY INDICATORS OF DROSOPHILA MELANOGASTER WHEN USING EXTRACTS REPRESENTATIVES OF THE GENUS MONARDA REGARDING INFLUENCE ANTI-TUMOR DRUGS
Authors: Antosyuk O.N. , Bolotnik E.V.
Published: February 2023

In the course of the analysis of the protective properties of representatives of the genus
Monarda, in relation to the antitumor drug methotrexate, a decrease in the lethality of Drosophila
melanogaster individuals was found with the simultaneous use of this drug and M. fistulosa extract
(100 mg/ml). With regard to exposure to etoposide, protective properties in terms of lethality were
determined for extracts of M. fistulosa var. menthifolia and M. didyma.
SELECTION OF PARAMETERS FOR OBTAINING EXTRACTS OF VALERIANA OFFICINALIS WITH ANTIOXIDANT PROPERIESS
Authors: Larina V.V. , Babich Olga , Voronova S , Chupakhin Evgeny
Published: February 2023

In this work, were obtained various extracts from the root of Valeriana officinalis and was studied their antioxidant activity by three methods, was studied the content of secondary metabolites of a phenolic nature. Biologically active substances were isolated from the extracts individually.
THE USE OF ENZYMES PRODUCED BY MICROORGANISMS IN THE FOOD INDUSTRY
Authors: Liyaskina I. G. , Milentyeva Irina
Published: February 2023

Objective: to study the most promising enzymes produced by microorganisms and used in
various branches of the food industry.
METHOD FOR PREPARATION THE SUM OF TRITERPENE GLYCOSIDES - IMPORTANT BIOLOGICALL ACTIVE COMPOUNS FROM THE FAR EASTERN EDIBLE HOLOTHURIA - Apostichopus japonicas
Authors: Mazeyka A. N. , Sanina N. M. , Pomazenkova L. A. , Barsova E. A.
Published: February 2023

Description of a method for preparation the sum of triterpene glycosides of the Far Eastern
edible holothuria - Apostichopus japonicus is given. The method utilize a food production waste as
a feedstock. The method includes a description of the procedures of procurement and storage of
feedstock, extraction and purification of triterpene glycosides. The characteristic of the resulting is
given.
ASSESSMENT OF BEHAVIORAL RISK FACTORS AS A WAY OF DESIGNING NEW PRODUCTS OF SPECIALIZED NUTRITION
Authors: Maksimov S. A. , Kurakin Mikhail , Kostina Natalya , Kotova M. B.
Published: February 2023

The aspects of designing new products are considered. The relevance of socio-demographic
data of the consumer is noted. A developed questionnaire consisting of 10 modules is proposed to
obtain data on behavioral risk factors of students of a higher educational institution. The survey will
allow a comprehensive assessment of the contextual impact on students of environmental conditions
and their individual eating patterns and habits.
THE EFFECT OF POLYMORPHISM OF THE MTHFR C677T GENE ON THE MORPHOFUNCTIONAL STATE OF LYMPHOCYTES DURING DRUG INTOXICATION
Authors: Astaf'eva E. A. , Tolochko T. A. , Timofeeva A. A.
Published: February 2023

The prevalence of opioid dependence among the able-bodied population is an important
medical and social problem. Methylenetetrahydrofolate reductase (MTHFR) plays a key role in the
metabolism of narcotic drugs. A decrease in the enzyme activity in polymorphic variants of the
gene encoding it is associated with a decrease in the immunity of opioid addiction patients.
METHODS OF MODIFICATION OF STARCHES FOR SPECIALIZED FOOD PRODUCTS
Authors: Markov Aleksandr
Published: February 2023

Methods of modification of native starches for use as the main component in specialized
food products are considered. Some modern physical, chemical and enzymatic methods of
processing starches and their influence on the properties of the resulting components are described.
THE ECONOMIC FEASIBILITY OF EXPANDING THE RANGE OF SPECIALIZED MEALS FOR SCHOOL MEALS
Authors: Mayurnikova Larisa , Vasilyuk N. V.
Published: February 2023

Objective: The article discusses the proposed solutions to the prevention of AZZ. The problem
of iodine deficiency has been known for a long time, but the measures currently applied do not have an
effect. It was proposed to develop a technology for preparing minced fish for school meals, taking into
account the ratio of consumer preferences and economic feasibility. The results showed the
effectiveness of this development of minced meat for implementation in school food factories.
CATERING DURING MASS SPORTS EVENTS
Authors: Merkulova N. V. , Krapiva Tatyana
Published: February 2023

The goal is to consider issues related to the organization of high–quality, varied and safe
nutrition of athletes and guests of the II Winter International Sports Games "Children of Asia", held
in the Kemerovo region – Kuzbass in 2023.
APPLICATION OF EGGSHELL MINERAL CONCENTRATE FOR BOILED SAUSAGES
Authors: Myshalova O , Dmitrienko I. S. , Roslikov D. A.
Published: February 2023

Theoretically and experimentally, the possibility of using an eggshell mineral concentrate
the production of boiled sausage products in an amount of no more than 1% has been substantiated.
The formulation and technology of production of boiled sausages enriched with calcium and
magnesium have been developed
THEORETICAL ASPECTS OF INCREASING THE SHELF LIFE OF GINGERBREAD
Authors: Nazimova E. V. , Zelenkova M. A.
Published: February 2023

Purpose: to study the factors affecting the preservation of the freshness of gingerbread, to
analyze possible measures to increase the shelf life of gingerbread.