bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Different Physical Therapy Interventions on Brain-Derived Neurotrophic Factor Levels in Chronic Musculoskeletal Pain Patients: A Systematic Review
Authors: Di-Bonaventura Silvia , Fernández-Carnero Josué , Matesanz-García Luis , Arribas-Romano Alberto , Polli Andrea , Ferrer-Peña Raúl
Published: January 2023

Objective: The main objectives of this review were, firstly, to study the effect of different physiotherapy interventions on BDNF levels, and, secondly, to analyze the influence of physiotherapy on pain levels to subsequently draw conclusions about its possible relationship with BDNF. Background: Based on the theory that neurotrophic factors such as BDNF play a fundamental role in the initiation and/or maintenance of hyperexcitability of central neurons in pain, it was hypothesized that the levels of this neurotrophic factor may be modified by the application of therapeutic interventions, favoring a reduction in pain intensity. Methods: A literature search of multiple electronic databases (Pubmed, PsycINFO, Medline (Ebsco), Scopus, WOS, Embase) was conducted to identify randomized control trials (RCTs) published without language restrictions up to and including March 2022. The search strategy was based on the combination of medical terms (Mesh) and keywords relating to the following concepts: “pain”, “chronic pain”, “brain derived neurotrophic factor”, “BDNF”, “physiotherapy”, and “physical therapy”. A total of seven papers were included. Results: There were two studies that showed statistically significant differences in pain intensity reduction and an increase in the BDNF levels that used therapies such as rTMS and EIMS in patients with chronic myofascial pain. However, the same conclusions cannot be drawn for the other physical therapies applied. Conclusions: rTMS and EIMS interventions achieved greater short-term reductions in pain intensity and increased BDNF over other types of interventions in chronic myofascial pain patients, as demonstrated by a moderate amount of evidence. In contrast, other types of physical therapy (PT) interventions did not appear to be more effective in decreasing pain intensity and increasing BDNF levels than placebo PT or minimal intervention, as a low amount of evidence was found.
Biodiversity of Phototrophs and Culturable Fungi in Gobustan Caves
Authors: Mazina Svetlana Evgenievna , Gasanova Tatiana Vladimirovna , Kozlova Ekaterina Vitalievna , Popkova Anna Vladimirovna , Fedorov Anton Sergeevich , Bukharina Irina Leonidovna , Pashkova Anna Sergeevna , Larionov Maxim Viktorovich , Abdullayev Rahman Rahim oglu , Isaev Vugar Urfat oglu
Published: January 2023

Unique natural objects, such as the caves of the Gobustan National Historical and Artistic Preserve, are also of great cultural and historical value due to rock art and sites of ancient people. A favorable microclimate makes these habitats convenient for colonization by microbiota, including phototrophs. In arid regions with intense seasonal fluctuations of microclimatic parameters, the conditions for survival are the least favorable; therefore, it becomes especially important to determine the composition of communities that are the most adapted to specific conditions. This work aimed to identify the biodiversity of communities of caves and grottoes of the Gobustan Reserve. The studies were carried out in July 2019. Samples were analyzed for cyanobacteria and algae by microscopy and cultivation methods, microfungi were isolated by soil dilution, and the fouling glass method was also used. In total, 29 taxa of cyanobacteria and algae, 18 taxa of fungi, and 3 species of mosses were identified. The studied habitats were dominated by the algae Chlorella vulgaris, Aphanocapsa sp., and Stichococcus bacillaris; the subdominants were Jaaginema subtilissimum, Leptolyngbya tenuis, Chlorococcum minutum, and Humidophila contenta. Microfungi had the highest occurrence of Aspergillus niger, Aureobasidium pullulans, Alternaria alternata, and Talaromyces ruber. It was noted that cyanobacteria dominated in morphologically differentiated biofilms and green algae on the rocks. The greatest number of microfungi was found in the aphotic zone and bryophyte tufts. The dominance of green algae is atypical for most caves of other regions and may be associated with intense lighting of habitats. The absence of protonema is a consequence of the aridity and low moisture content of the substrates.
Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature
Authors: Kopanou Taliaka Paschalia , Tsantes Andreas G. , Konstantinidi Aikaterini , Houhoula Dimitra , Tsante Konstantina A. , Vaiopoulos Aristeidis G. , Piovani Daniele , Nikolopoulos Georgios K. , Bonovas Stefanos , Iacovidou Nicoletta , Tsantes Argirios E. , Sokou Rozeta
Published: January 2023

(1) Background: Although invasive fungal infections are a major cause of neonatal morbidity and mortality, data on the incidence and outcomes of localized abscesses in solid organs due to fungal infections are scarce. The aim of this study was to consolidate evidence and enhance our understanding on neonatal liver abscesses due to invasive fungal infections. (2) Methods: An electronic search of the PubMed and Scopus databases was conducted, considering studies that evaluated fungal liver abscesses in the neonatal population. Data on the epidemiology, clinical course, treatment, and outcome of these infections were integrated in our study. (3) Results: Overall, 10 studies were included presenting data on 19 cases of neonatal fungal liver abscesses. Candida spp. were the most common causative pathogens (94.7%). Premature neonates constituted the majority of cases (93%), while umbilical venous catheter placement, broad spectrum antibiotics, and prolonged parenteral nutrition administration were identified as other common predisposing factors. Diagnosis was established primarily by abdominal ultrasonography. Medical therapy with antifungal agents was the mainstay of treatment, with Amphotericin B being the most common agent (47%). Abscess drainage was required in four cases (21%). Eradication of the infection was achieved in the majority of cases (80%). (4) Conclusions: Even though fungal liver abscess is a rare entity in the neonatal population, clinicians should keep it in mind in small, premature infants who fail to respond to conventional treatment for sepsis, particularly if an indwelling catheter is in situ. A high index of suspicion is necessary in order to achieve a timely diagnosis and the initiation of the appropriate treatment.
Finite-Element Modeling of the Hysteresis Behavior of Tetragonal and Rhombohedral Polydomain Ferroelectroelastic Structures
Authors: Lobanov Sviatoslav M. , Semenov Artem S.
Published: January 2023

The influence of the domain structure’s initial topology and its evolution on the hysteresis curves of tetragonal and rhombohedral polydomain structures of ferroelectroelastic materials is studied. Based on the analysis of electrical and mechanical compatibility conditions, all possible variants of representative volume elements of tetragonal and rhombohedral second-rank-domain laminate structures were obtained and used in simulations. Considerable local inhomogeneity of stress and electric fields within the representative volume, as well as domain interaction, necessitates the use of numerical methods. Hysteresis curves for laminated domain patterns of the second rank were obtained using finite-element homogenization. The vector-potential finite-element formulation as the most effective method was used for solving nonlinear coupled boundary value problems of ferroelectroelasticity. A significant anisotropy of the hysteresis properties of domain structures was established both within individual phases and when comparing the tetragonal and rhombohedral phases. The proposed approach describes the effects of domain hardening and unloading nonlinearity.
Effect of Graphitization Degree of Mesocarbon Microbeads (MCMBs) on the Microstructure and Properties of MCMB-SiC Composites
Authors: Huang Shijie , Yao Xiumin , Bai Jialin , Huang Zhengren , Liu Xuejian
Published: January 2023

Mesocarbon microbead-silicon carbide (MCMB-SiC) composites were prepared by hot-press sintering (2100 °C/40 MPa/1 h) with two different graphitized MCMBs as the second phase, which exhibited good self-lubricating properties. The effects of the graphitization degree of the MCMBs on the microstructure and properties of the composites were investigated contrastively. The results showed that the composites that added raw MCMBs with a low degree of graphitization had excellent self-sintering properties, higher densities, and better mechanical properties; by comparison, the composites that added mature MCMBs with a high degree of graphitization, which has regular and orderly lamellar structures, not only had good mechanical properties but also exhibited a lower and more stable dry friction coefficient (0.35), despite the higher wear rate (2.66 × 10−6 mm3·N−1·m−1). Large amounts of mature MCMBs were peeled off during the friction process to form a uniform and flat graphite lubricating film, which was the main reason for reducing the dry friction coefficient of the self-lubricating composites and making the friction coefficient more stable.
Light-Controlled Rotational Speed of an Acoustically Levitating Photomobile Polymer Film
Authors: Lucchetta Daniele Eugenio , Castellini Paolo , Martarelli Milena , Scalise Lorenzo , Pandarese Giuseppe , Riminesi Cristiano , Singh Gautam , Di Donato Andrea , Francescangeli Oriano , Castagna Riccardo
Published: January 2023

In this work, we study the light-induced changes of the rotational speed of a thin photomobile film using a single-axis acoustic levitator operating at 40 kHz. In our experiments, a 50 μm thick photomobile polymer film (PMP) is placed in one of the nodes of a stationary acoustic field. Under the action of the field, the film remains suspended in air. By externally perturbing this stable equilibrium condition, the film begins to rotate with its natural frequency. The rotations are detected in real time by monitoring the light of a low power He–Ne laser impinging on and reflected by the film itself. During the rotational motion, an external laser source is used to illuminate the PMP film; as a consequence, the film bends and the rotational speed changes by about 20 Hz. This kind of contactless long-distance interaction is an ideal platform for the development and study of many electro-optics devices in microgravity and low-friction conditions. In particular, we believe that this technology could find applications in research fields such as 3D dynamic displays and aerospace applications.
Harsh Environmental-Tolerant and High-Performance Triboelectric Nanogenerator Based on Nanofiber/Microsphere Hybrid Membranes
Authors: Sun Dequan , Cao Ruirui , Wu Haoyi , Li Xin , Yu Haoran , Guo Lijin
Published: January 2023

Triboelectric nanogenerator (TENG) can convert tiny mechanical energy into precious electrical energy. Constant improvements to the output performance of TENG is not only the driving force for its sustainable development, but also the key to expand its practical applicability in modern smart devices. However, most previous studies were conducted at room temperature, ignoring the influence of temperature on the output performance of TENG. Additionally, due to thermionic emission effect, the electrons transferred to a dielectric surface can be released into a vacuum after contact electrification. Therefore, TENG cannot maintain an effective electrical output under high-temperature conditions. Here, a series of high-temperature operatable flexible TENGs (HO-TENGs) based on nanofiber/microsphere hybrid membranes (FSHMs) was fabricated by electrospinning and electrospraying. The Voc of HO-TENG is 212 V, which is 2.33 times higher than that of control TENG. After 10,000 cycle stability tests, the HO-TENG shows excellent durability. Especially, this HO-TENG can maintain 77% electrical output at 70 °C compared to room temperature, showing excellent high-temperature operability. This study can not only provide a reference for the construction of advanced high-performance TENG, but also provide a certain experimental basis for efficient collection of mechanical energy in high-temperature environment and promote the application of TENG devices in harsh environments.
The Effect of Glass Structure on the Luminescence Spectra of Sm3+-Doped Aluminosilicate Glasses
Authors: Herrmann Andreas , Zekri Mohamed , Maalej Ramzi , Rüssel Christian
Published: January 2023

Peralkaline Sm3+-doped aluminosilicate glasses with different network modifier ions (Mg2+, Ca2+, Sr2+, Ba2+, Zn2+) were investigated to clarify the effect of glass composition and glass structure on the optical properties of the doped Sm3+ ions. For this purpose, the Sm3+ luminescence emission spectra were correlated with the molecular structure of the glasses derived by molecular dynamics (MD) simulations. The different network modifier ions have a clear and systematic effect on the peak area ratio of the Sm3+ emission peaks which correlates with the average rare earth site symmetry in the glasses. The highest site symmetry is found for the calcium aluminosilicate glass. Glasses with network modifier ions of lower and higher ionic radii show a notably lower average site symmetry. The symmetry could be correlated to the rare earth coordination number with oxygen atoms derived by MD simulations. A coordination number of 6 seems to offer the highest average site symmetry. Higher rare earth coordination probabilities with non-bridging oxygen result in an increased splitting of the emission peaks and a notable broadening of the peaks. The zinc containing glass seems to play a special role. The Zn2+ ions notably modify the glass structure and especially the rare earth coordination in comparison to the other network modifier ions in the other investigated glasses. The knowledge on how glass structure affects the optical properties of doped rare earth ions can be used to tailor the rare earth absorption and emission spectra for specific applications.
Helical Milling of CFRP/Ti6Al4V Stacks Using Nano Fluid Based Minimum Quantity Lubrication (NF-MQL): Investigations on Process Performance and Hole Integrity
Authors: Mughal Kiran , Mughal Mohammad Pervez , Farooq Muhammad Umar , Qaiser Saleem Muhammad , Haber Guerra Rodolfo
Published: January 2023

The structural components in the aeronautical industry require CFRP/Ti6Al4V stacks to be processed together, which results in poor hole integrity due to the thermal properties of the materials and challenges related to processability. These challenges include quality variation of the machined holes because of the limitations in process properties. Therefore, a novel solution through helical milling is investigated in the study using nano fluid based minimum quantity lubrication (NF-MQL). The analysis of variance shows, for Ti6Al4V, eccentricity (PCR = 28.56%), spindle speed (Ti) (PCR = 42.84%), and tangential feed (PCR = 8.61%), and for CFRP, tangential feed (PCR = 40.16%), spindle speed (PCR = 28.75%), and eccentricity (PCR = 8.41%) are the most significant parameters for diametric error. Further on, the rise in the circularity error is observed because of prolonged tool engagement at a higher value of tangential feed. Moreover, the surface roughness of Ti was reduced with an increasing percentage of MoS2 in the lubricant. The spindle speed (37.37%) and lubricant (45.76%) have a potential influence on the processing temperature, as evident in the analysis of variance. Similarly, spindle speed Ti (61.16%), tangential feed (23.37%), and lubrication (11.32%) controlled flank wear, which is critical to tool life. Moreover, the concentration of MoS2 decreased edge wear from ~105 µm (0.5% concentration) to ~70 µm (1% concentration). Thorough analyses on process performance in terms of hole accuracy, surface roughness, processing temperature, and tool wear are carried out based on the physical science of the process for cleaner production. The NF-MQL has significantly improved process performance and hole integrity.
Association between Novel Hematological Indices and Measures of Disease Activity in Patients with Rheumatoid Arthritis
Authors: Choe Jung-Yoon , Lee Chan Uk , Kim Seong-Kyu
Published: January 2023

Background and Objectives: Hematological indices have been known to be available markers used for evaluating disease activity in rheumatoid arthritis (RA). This study serves to verify the association between four different hematological indices and disease activity measures in patients with RA. Materials and Methods: The study included 257 female RA patients and 71 age-matched female controls. Four hematological indices, namely systemic immune-inflammation index (SII), neutrophil-to-hemoglobin and lymphocyte (NHL) score, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), were evaluated. Composite measures of RA included Disease Activity Score 28 joints (DAS28), the simplified disease activity index (SDAI), and the clinical disease activity index (CDAI). Results: Patients with RA showed statistically higher SII, NHL score, NLR, and PLR compared with controls. SII and NHL score were significantly associated with DAS28 erythrocyte sedimentation rate (DAS28-ESR), DAS28 C-reactive protein (DAS28-CRP), CDAI, and SDAI, whereas NLR was related to DAS28-CRP, CDAI, and SDAI. SII, NHL score, and NLR tended to increase as disease activity based on DAS28-ESR, DAS28-CRP, and CDAI worsened. In the analysis using receiver operating characteristic curve of hematological indices for diagnostic accuracy, the area under the curve was 0.703 (95% confidence interval, CI 0.637–0.769, p < 0.001) for SII and 0.705 (95% CI 0.639–0.770, p < 0.001) for NHL score, which showed acceptable potential for the diagnosis of RA. Four hematological indices showed weak potential for the detection of remission. Conclusions: The present study results showed that SII and NHL scores might be useful markers that adequately reflect disease activity and lead to more accurate diagnosis in RA.
Evaluation of FAU-type Zeolite Membrane Stability in Transesterification Reaction Conditions
Authors: Ikeda Ayumi , Matsuura Wakako , Abe Chie , Lundin Sean-Thomas Bourne , Hasegawa Yasuhisa
Published: January 2023

The transesterification conversion of methyl ether can be enhanced by the removal of the byproduct methanol using methanol permselective faujasite (FAU-type) zeolite membranes. However, the authors previously observed that the methanol flux during the transesterification reaction was lower than the predicted flux. Therefore, this study investigated the stability of FAU-type zeolite membranes in the presence of organic components associated with the transesterification reaction of methyl hexanoate and 1-hexanol. The stability was defined in terms of changes in methanol permeance and zeolite structure. The effect of reaction components (methanol, 1-hexanol, methyl hexanoate, and hexyl hexanoate) on the FAU-type zeolite structure and the methanol permeation performance of the FAU-type zeolite membranes were evaluated to find the component causing the lower methanol flux. From these results, two esters were found to adsorb strongly on the FAU-type zeolite. The methanol flux of the FAU-type zeolite membrane was examined after vapor exposure of each of the four reaction chemicals at 373 K for 8 h. In the case of methyl hexanoate and hexyl hexanoate vapor exposure, the methanol flux was reduced by about 75% compared to the initial flux of 15 kg m−2 h−1. These results indicated methanol permeation performance was inhibited by the adsorption of esters.
Fabrication and Investigation of Acid Functionalized CNT Blended Nanocomposite Hollow Fiber Membrane for High Filtration and Antifouling Performance in Ultrafiltration Process
Authors: Yang Eunmok , Park Shinyun , Kim Yeji , Yanar Numan , Choi Heechul
Published: January 2023

In this study, we fabricated a nanocomposite polyethersulfone (PES) HF membrane by blending acid functionalized carbon nanotubes (FCNT) to address the issue of reduced membrane life, increased energy consumption, and operating costs due to low permeability and membrane fouling in the ultrafiltration process. Additionally, we investigated the effect of FCNT blending on the membrane in terms of the physicochemical properties of the membrane and the filtration and antifouling performance. The FCNT/PES nanocomposite HF membrane exhibited increased water permeance from 110.1 to 194.3 LMH/bar without sacrificing rejection performance and increased the flux recovery ratio from 89.0 to 95.4%, compared to a pristine PES HF membrane. This study successfully developed a high filtration and antifouling polymer-based HF membrane by blending FCNT. Furthermore, it was validated that blending FCNT into the membrane enhances the filtration and antifouling performance in the ultrafiltration process.
Double-Layered Pebax® 3533/ZIF-8 Membranes with Single-Walled Carbon Nanotube Buckypapers as Support for Gas Separation
Authors: Berned-Samatán Víctor , Téllez Carlos , Coronas Joaquín
Published: January 2023

Single-walled carbon nanotube buckypapers (SWCNT-bps) coated with a metal–organic framework ZIF-8 layer were used as supports for the preparation of Pebax® 3533 TFC membranes by both phase inversion and spin coating techniques. Upon proper characterization of the materials by X-ray diffraction, IR spectroscopy, thermogravimetry and electron microscopy, the obtained membranes were tested in gas separation experiments with a 15:85 CO2/N2 mixture. These experiments proved that the ZIF-8 layer prevented from the penetration of the polymer selective film into the SWCNT-bp support, giving rise to a highly permeable selective membrane. The optimum membrane was achieved by the spin-coating method, with better permeation results than that prepared by the phase inversion method, obtaining a CO2 permeance of 566 GPU together with a CO2/N2 selectivity of 20.9.
Grain Structure Rearrangement by Means the Advanced Statistical Model Modified for Describing Dynamic Recrystallization
Authors: Trusov Peter , Kondratev Nikita , Podsedertsev Andrej
Published: January 2023

The study of grain and defect structure evolution in materials subjected to thermomechanical processing is still an urgent problem because the state of a structure substantially determines the physical and mechanical macro properties of polycrystals and polycrystalline products. Significant changes in the structure of polycrystalline materials are associated with the process of dynamic recrystallization (DRX). To investigate DRX, an extended statistical model of inelastic deformation with internal variables is proposed, which takes into consideration contact interactions between neighboring grains. We constructed a geometric image of the grain structure by applying a Laguerre polyhedron in order to describe such interactions in the statistical framework. During the recrystallization simulation, this image is being reconstructed as new recrystallized grains emerge. This leads to the problem of establishing correspondence between an initial grain structure and a reconstructed structure with the required statistical consistency. To provide such consistency, an optimization problem is formulated to preserve the stress and strain parameters and the recrystallization driving force from changes in a statistical sense. This problem is posed with respect to the distributions of differences in defect-stored energy, mutual misorientation angles between grains and sizes of these grains. A genetic algorithm is applied for resolution. By the example of simulating inelastic deformation of a representative volume element (a macrosample analogue) of polycrystalline copper, the influence of the mentioned distributions on the material response upon structure reconstruction is shown. Reasonable values for the objective weights and the genetic algorithm parameters were obtained. This paper presents a detailed description of the grain structure correspondence establishment method, the formulation of the optimization problem and the algorithm to resolve it.
α-Methyltryptamine (α-MT) Metabolite Profiling in Human Hepatocyte Incubations and Postmortem Urine and Blood
Authors: Malaca Sara , Bottinelli Charline , Fanton Laurent , Cartiser Nathalie , Carlier Jeremy , Busardò Francesco Paolo
Published: January 2023

α-MT is a hallucinogenic and stimulant tryptamine that was involved in several overdose fatalities in the United States and Europe. Analytical toxicology, and particularly the identification of metabolite biomarkers in biological samples, often is the only way to prove tryptamine use in clinical and forensic caseworks. We aimed to identify optimal α-MT metabolite biomarkers of consumption in humans. We identified α-MT metabolites in 10-donor-pooled human hepatocyte incubations and postmortem urine and blood from an α-MT overdose case using in silico metabolite predictions, liquid chromatography high-resolution-tandem mass spectrometry (LC-HRMS/MS), and software-assisted data mining. Nine metabolites were identified in vitro and eight additional metabolites were found in urine; five metabolites were found in blood. Metabolic transformations were hydroxylation, O-sulfation, O-glucuronidation, N-glucuronidation, and N-acetylation, consistent with the metabolism of structural analogues. The findings in hepatocyte incubations and postmortem samples were consistent, proving the in vitro model suitability. We suggest α-MT, hydroxy-α-MT glucuronide, and two hydroxy-α-MT sulfates as biomarkers of α-MT use in non-hydrolyzed urine; we suggest α-MT, two hydroxy-α-MT sulfates and N-acetyl-α-MT as biomarkers of α-MT use in blood. Further studies on α-MT clinical and forensic caseworks with different doses and routes of administration are necessary to better explore α-MT metabolism.
Electrolysis of Bacteria Based on Microfluidic Technology
Authors: Zhao Jianqiu , Li Na , Zhou Xinyu , Yu Zihan , Lan Mei , Chen Siyu , Miao Jiajia , Li Yulai , Li Guiying , Yang Fang
Published: January 2023

Cell lysis is a key step for studying the structure and function of proteins in cells and an important intermediate step in drug screening, cancer diagnosis, and genome analysis. The current cell lysis methods still suffer from limitations, such as the need for large instruments, a long and time-consuming process, a large sample volume, chemical reagent contamination, and their unsuitability for the small amount of bacteria lysis required for point-of-care testing (POCT) devices. Therefore, a fast, chemical-free, portable, and non-invasive device needs to be developed. In the present study, we designed an integrated microfluidic chip to achieve E. coli lysis by applying an alternating current (AC) electric field and investigated the effects of voltage, frequency, and flow rate on the lysis. The results showed that the lysis efficiency of the bacteria was increased with a higher voltage, lower frequency, and lower flow rate. When the voltage was at 10 Vp-p, the lysis efficiency was close to 100%. The study provided a simple, rapid, reagent-free, and high-efficiency cleavage method for biology and biomedical applications involving bacteria lysis.
Extraction of Low-Dimensional Structures of Noble and Rare Metals from Carbonaceous Ores Using Low-Temperature and Energy Impacts at Succeeding Stages of Raw Material Transformation
Authors: Aleksandrova Tatiana , Nikolaeva Nadezhda , Afanasova Anastasia , Romashev Artyem , Aburova Valeriya , Prokhorova Evgeniya
Published: January 2023

The possibility of extraction of metals from ores of different genesis, containing low-dimensional structures of rare and noble metals, increases their commodity value and, in a deficit for some types of metals, leads to the need to search and develop new nature-like technologies, which can be used to extract from ores of different genesis almost all valuable noble, rare earth and nonferrous metals regardless of their concentration. This article presents the results of studying the processes of comminution and flotation to extract low-dimensional structures of noble and rare metals from carbonaceous ores using low-temperature and energy impacts at successive stages of the ores’ transformation. With the use of modern mineralogical, physical and chemical methods of research of composition, structure and properties of ores, the initial samples, concentrates and tailings after enrichment were studied. During the study, it was established that the difficulty of extraction of strategic metals from carbonaceous hard-enriched ores consists in fine dissemination of valuable components in concentrator minerals, mutual penetration of ore mineralization into each other and into rock-forming minerals, and in proximity of physical, chemical and technological properties of minerals, which complicates selective extraction of valuable components in concentrates. Also, difficulties in enrichment are associated with high flotation activity of waste rock, which significantly reduces the quality of concentrates.
CO2 Dipole Moment: A Simple Model and Its Implications for CO2-Rock Interactions
Authors: Calcara Massimo , Caricaterra Matteo
Published: January 2023

CO2 is a widespread fluid naturally occurring within the Earth crust or injected in deep strata for technological issues such as Carbon Capture and Storage (CCS). At STP conditions, CO2 is a gas, with a net zero dipole moment. Growing pressures produce an increase in its density. The reduced intermolecular distance causes a variation in the molecular structure, due to the intensification of mutual interactions. Some published spot data reveal the departure from the planarity of the bond angle while others provide few values of the CO2 dipole moment. Based on a small amount of literature-measured angle values, it was possible first to extrapolate a correlation between bond angle and density (R2 = 0.879). By fixing the partial charges distribution, we present a simple model that allows the calculation of the CO2 dipole moment directly from the geometry of the molecule, in the range of 179–162 degrees, 1-degree step. Results give values up to about 1 D. Being aware that this model is qualitative, it gives, however, an explanation of the experimental reactivity, and it also provides a valid tool in identifying zones in the crust where these reactions are likely to occur efficiently. Finally, we hypothesise the role of dry CO2 in the carbonate formation through the interactions with the basalts.
Highly Sensitive Multi-Channel Biosensor for Low-Interference Simultaneous Detection
Authors: Su Jiapeng , Xiao Gongli , Yang Hongyan , Chen Jiayu , Li Haiou , Liu Xingpeng , Luo Yunhan , Li Jianqing
Published: January 2023

In this paper, we propose a multi-channel photonic crystal fiber sensor, which adopts dual-polarization and multiple materials to effectively reduce the mutual interference between channels and enhance the surface plasmon resonance, thus achieving simultaneous detection of a multi-channel with low interference. Four channels are polished around the cylindrical fiber, and then different metal films (gold or silver) and plasmonic materials (titanium dioxide, thallium pentoxide, or graphene) are added to the sensing area of each channel. All channels detect refractive indices in the range of 1.34 to 1.42. The sensing performance of the fiber optic sensor was numerically investigated using the full vector finite element method. After the optimization of structural parameters, the maximum wavelength sensitivity of channel-1, channel-2, channel-3, and channel-4 are 49,800 nm/RIU, 49,000 nm/RIU, 35,900 nm/RIU, and 36,800 nm/RIU, respectively. We have theoretically analyzed the sensor’s capabilities for partial bio-detection and simulated its detection capability with a wavelength sensitivity of 11,500 nm/RIU for normal red blood cells and 12,200 nm/RIU for MCF-7 cancerous cells. Our proposed sensor has a novel design, can detect multiple channels simultaneously, has strong anti-interference capability and high sensitivity, and has good sensing characteristics.
Revisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine
Authors: Lerin Carles , Collado María Carmen , Isganaitis Elvira , Arning Erland , Wasek Brandi , Demerath Ellen W. , Fields David A. , Bottiglieri Teodoro
Published: January 2023

Breastfeeding is the gold standard for early nutrition. Metabolites from the one-carbon metabolism pool are crucial for infant development. The aim of this study is to compare the breast-milk one-carbon metabolic profile to other biofluids where these metabolites are present, including cord and adult blood plasma as well as cerebrospinal fluid. Breast milk (n = 142), cord blood plasma (n = 23), maternal plasma (n = 28), aging adult plasma (n = 91), cerebrospinal fluid (n = 92), and infant milk formula (n = 11) samples were analyzed by LC-MS/MS to quantify choline, betaine, methionine, S-adenosylmethionine, S-adenosylhomocysteine, total homocysteine, and cystathionine. Differences between groups were visualized by principal component analysis and analyzed by Kruskal–Wallis test. Correlation analysis was performed between one-carbon metabolites in human breast milk. Principal component analysis based on these metabolites separated breast milk samples from other biofluids. The S-adenosylmethionine (SAM) concentration was significantly higher in breast milk compared to the other biofluids and was absent in infant milk formulas. Despite many significant correlations between metabolites in one-carbon metabolism, there were no significant correlations between SAM and methionine or total homocysteine. Together, our data indicate a high concentration of SAM in breast milk, which may suggest a strong demand for this metabolite during infant early growth while its absence in infant milk formulas may indicate the inadequacy of this vital metabolic nutrient.
Identification of Nanoparticle Properties for Optimal Drug Delivery across a Physiological Cell Barrier
Authors: Ross Aisling M. , Cahalane Rachel M. , Walsh Darragh R. , Grabrucker Andreas M. , Marcar Lynnette , Mulvihill John J. E.
Published: January 2023

Nanoparticles (NPs) represent an attractive strategy to overcome difficulties associated with the delivery of therapeutics. Knowing the optimal properties of NPs to address these issues could allow for improved in vivo responses. This work investigated NPs prepared from 5 materials of 3 sizes and 3 concentrations applied to a cell barrier model. The NPs permeability across a cell barrier and their effects on cell barrier integrity and cell viability were evaluated. The properties of these NPs, as determined in water (traditional) vs. media (realistic), were compared to cell responses. It was found that for all cellular activities, NP properties determined in media was the best predictor of the cell response. Notably, ZnO NPs caused significant alterations to cell viability across all 3 cell lines tested. Importantly, we report that the zeta potential of NPs correlates significantly with NP permeability and NP-induced changes in cell viability. NPs with physiological-based zeta potential of −12 mV result in good cell barrier penetration without considerable changes in cell viability.
pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
Authors: Pilch Joanna , Potęga Agnieszka , Kowalczyk Agata , Kasprzak Artur , Kowalik Patrycja , Bujak Piotr , Paluszkiewicz Ewa , Augustin Ewa , Nowicka Anna M.
Published: January 2023

Selective therapy and controlled drug release at an intracellular level remain key challenges for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating molecule in nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) for the delivery of antitumor unsymmetrical bisacridine compound (C-2028) to lung and prostate cancers as well as normal cells. The bisacridine derivative can form the inclusion complex with β-cyclodextrin molecule, due to the presence of a planar fragment in its structure. The stability of such a complex is pH-dependent. The drug release profile at different pH values and the mechanism of C-2028 release from QDs-β-CD-FA nanoconjugates were investigated. Next, the intracellular fate of compounds and their influence on lysosomal content in the cells were also studied. Confocal Laser Scanning Microscopy studies proved that all investigated compounds were delivered to acidic organelles, the pH of which promoted an increased release of C-2028 from its nanoconjugates. Since the pH in normal cells is higher than in cancer cells, the release of C-2028 from its nanoconjugates is decreased in these cells. Additionally, we obtained the concentration profiles of C-2028 in the selected cells treated with unbound C-2028 or nanoconjugate by the HPLC analysis.
Traditional, Therapeutic Uses and Phytochemistry of Terrestrial European Orchids and Implications for Conservation
Authors: Bazzicalupo Miriam , Calevo Jacopo , Smeriglio Antonella , Cornara Laura
Published: January 2023

The Orchidaceae family accounts for about 28,000 species, and most of them are mentioned in the folk medicine of nations around the world. The use of terrestrial orchids in European and Mediterranean regions has been reported since ancient times, but little information is available on their medicinal properties, as well as on their phytochemicals and biological activities. However, plant collection for human use is still listed as one of the main threats for terrestrial orchids, alongside other menacing factors such as wrong habitat management and disturbance to symbionts, such as pollinators and mycorrhizal fungi. Therefore, the primary aim of this review was to resume and discuss available information regarding the past and current popular uses of European orchids. We then grouped phytochemical data to evaluate the presence of bioactive compounds of pharmacological relevance, and we discussed whether these could support the therapeutic employment of the different organs. Finally, we briefly debated the sustainability of orchid utilizations, considering the different threatening factors and conservation actions including plant propagation methods.
Occurrence, Function, and Biosynthesis of the Natural Auxin Phenylacetic Acid (PAA) in Plants
Authors: Perez Veronica C. , Zhao Haohao , Lin Makou , Kim Jeongim
Published: January 2023

Auxins are a class of plant hormones playing crucial roles in a plant’s growth, development, and stress responses. Phenylacetic acid (PAA) is a phenylalanine-derived natural auxin found widely in plants. Although the auxin activity of PAA in plants was identified several decades ago, PAA homeostasis and its function remain poorly understood, whereas indole-3-acetic acid (IAA), the most potent auxin, has been used for most auxin studies. Recent studies have revealed unique features of PAA distinctive from IAA, and the enzymes and intermediates of the PAA biosynthesis pathway have been identified. Here, we summarize the occurrence and function of PAA in plants and highlight the recent progress made in PAA homeostasis, emphasizing PAA biosynthesis and crosstalk between IAA and PAA homeostasis.
The Effect of Thermal Annealing on the Structure and Gas Transport Properties of Poly(1-Trimethylsilyl-1-Propyne) Films with the Addition of Phenolic Antioxidants
Authors: Kossov Anton , Makrushin Vladimir , Levin Ivan , Matson Samira
Published: January 2023

The thermally activated relaxation of poly(1-trimethylsilyl-1-propyne) (PTMSP) samples of various cis-/trans-compositions (50–80% units of cis-configuration) in the presence of phenolic antioxidants of various structures was investigated. It was pointed out that polymers with a high content of cis-units exhibited greater thermal-oxidative stability due to the greater flexibility of the cis-enriched macrochains. The use of hindered phenols as antioxidants made it possible to prevent the process of thermally initiated oxidative degradation. At the same time, the most effective stabilizing agents were antioxidants with larger molecules such as Vulkanox BKF, Irganox 1010, and Irganox 1076. It was shown that the permeability coefficients of stabilized PTMSP during thermal treatment initially slightly decreased (by 20–30%), which, according to the X-ray diffraction data, was associated with an increase in the density of the macrochain packing, and during further heating remained practically unchanged. Note that for the cis-enriched samples, no signs of oxidation or decrease in the transport characteristics were observed during polymer heating for 240 h at 140 °C.
Structural Performance of Waste Plastic Bottles Modified Asphalt: A Review
Authors: Shah Abdul Muqeet , Lodhi Rida Hameed , Javed Muhammad Faisal , Jasiński Michał , Jasińska Elżbieta , Gono Miroslava
Published: January 2023

The usage of plastic materials in our daily life is increasing day by day. These plastic materials are somehow beneficial for us, but the disposal of waste plastic materials has become a serious problem. The use of plastic not only enhances road construction but also helps extend the life of roads and improves the environment. Waste plastics use in roads increases durability and also reduces water retention. This research reviews the use of waste plastics in asphalt pavement. In this study, the properties such as Marshall stability, flow, resilient modulus, fatigue, etc., are studied to boost the usage of waste plastic in asphalt pavements. It is concluded that with the use of waste plastic in asphalt pavement, the quality of roads will be enhanced, and it will also be very beneficial for our environment. The other major advantage is that it will be very cost-effective for underdeveloped countries.
Blind Super-Resolution for SAR Images with Speckle Noise Based on Deep Learning Probabilistic Degradation Model and SAR Priors
Authors: Zhang Chongqi , Zhang Ziwen , Deng Yao , Zhang Yueyi , Chong Mingzhe , Tan Yunhua , Liu Pukun
Published: January 2023

As an active microwave coherent imaging technology, synthetic aperture radar (SAR) images suffer from severe speckle noise and low-resolution problems due to the limitations of the imaging system, which cause difficulties in image interpretation and target detection. However, the existing SAR super-resolution (SR) methods usually reconstruct the images by a determined degradation model and hardly consider multiplicative speckle noise, meanwhile, most SR models are trained with synthetic datasets in which the low-resolution (LR) images are down-sampled from their high-resolution (HR) counterparts. These constraints cause a serious domain gap between the synthetic and real SAR images. To solve the above problems, this paper proposes an unsupervised blind SR method for SAR images by introducing SAR priors in a cycle-GAN framework. First, a learnable probabilistic degradation model combined with SAR noise priors was presented to satisfy various SAR images produced from different platforms. Then, a degradation model and a SR model in a unified cycle-GAN framework were trained simultaneously to learn the intrinsic relationship between HR–LR domains. The model was trained with real LR and HR SAR images instead of synthetic paired images to conquer the domain gap. Finally, experimental results on both synthetic and real SAR images demonstrated the high performance of the proposed method in terms of image quality and visual perception. Additionally, we found the proposed SR method demonstrates the tremendous potential for target detection tasks by reducing missed detection and false alarms significantly.
Monitoring Urban Expansion by Coupling Multi-Temporal Active Remote Sensing and Landscape Analysis: Changes in the Metropolitan Area of Cordoba (Argentina) from 2010 to 2021
Authors: Marzialetti Flavio , Gamba Paolo , Sorriso Antonietta , Carranza Maria Laura
Published: January 2023

Uncontrolled and unsustainable urban sprawl are altering the Earth’s surface at unprecedented rates. This research explores the potential of active remote sensors for mapping urban areas, for monitoring urban expansion processes and for depicting landscape pattern dynamics in a metropolis of South America. Based on multi-temporal urban cover maps of Cordoba, Argentina, purposely derived from COSMO-SkyMed SAR data by urban extraction algorithms, we quantified urban surface increase and described urbanization processes that occurred during 2010–2021 in sectors with different degrees of soil sealing. We extracted urban extent in four time-steps using an Urban EXTent extraction (UEXT) algorithm and quantified urban expansion, identifying newly built areas on 2.5 ha cells. For these cells, we computed urban cover and a set of landscape pattern indices (PIs), and by projecting them in a composition vs. configuration Cartesian space we performed a trajectory analysis. SAR-based urban extraction and cover change proved to be very accurate. Overall accuracy and Cohen’s Kappa statistic evidenced very high values, always above 91.58% and 0.82, respectively, for urban extraction, and also above 90.50% and 0.72 concerning the accuracy of urban expansion. Cordoba’s urban surface significantly increased (≈900 ha in 10 years) following three main spatial processes in different city sectors (e.g., edge-expansion and outlying on peri-urban areas, and infill inside the ring road), which may have contrasting effects on the sustainability of the metropolitan area. Trajectory analysis highlighted non-linear relations between the urban cover and the PIs. Areas with very low and low urban intensity underwent a steep rise of both urban cover and PI values (e.g., urban patch dimension, complexity and number), depicting urban edge-expansion and outlying processes. In the areas with medium and high urban intensity the increase in patch dimension, along with the decrease in patch number and complexity, evidence the coalescence of urban areas that incorporate in the urban fabric the remnants of non-built up zones and fill the few residual green spaces. The proposed SAR mapping procedure coupled with landscape analysis proved to be useful to detect and depict different moments of urban expansion and, pending more tests on other cities and geographical conditions, it could be postulated among the RS indicators to monitor the achievement of the Sustainable Development Goals established by the United Nations.
Supervised versus Semi-Supervised Urban Functional Area Prediction: Uncertainty, Robustness and Sensitivity
Authors: Deng Rui , Guan Yanning , Cai Danlu , Yang Tao , Fraedrich Klaus , Zhang Chunyan , Tang Jiakui , Liao Zhouwei , Wei Zhishou , Guo Shan
Published: January 2023

To characterize a community-scale urban functional area using geo-tagged data and available land-use information, several supervised and semi-supervised models are presented and evaluated in Hong Kong for comparing their uncertainty, robustness and sensitivity. The following results are noted: (i) As the training set size grows, models’ accuracies are improved, particularly for multi-layer perceptron (MLP) or random forest (RF). The graph convolutional network (GCN) (MLP or RF) model reveals top accuracy when the proportion of training samples is less (greater) than 10% of the total number of functional areas; (ii) With a large amount of training samples, MLP shows the highest prediction accuracy and good performances in cross-validation, but less stability on same training sets; (iii) With a small amount of training samples, GCN provides viable results, by incorporating the auxiliary information provided by the proposed semantic linkages, which is meaningful in real-world predictions; (iv) When the training samples are less than 10%, one should be cautious using MLP to test the optimal epoch for obtaining the best accuracy, due to its model overfitting problem. The above insights could support efficient and scalable urban functional area mapping, even with insufficient land-use information (e.g., covering only ~20% of Beijing in the case study).