bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-inflammatory and Analgesic Activity of Cleome brachycarpa Ethanolic Extract in Lower Mammals and Effects on Blood and Liver Enzymes
Authors: Naeem Hira , Gul Somia , Khan Maria , Hamid Shaista , Leghari Qurratul Ain , Yasin Hina , Perveen Rehana
Published: May 2023

Background: Cleome brachycarpa, magical species full of phytochemicals, has magical medicinal properties and should be evaluated extensively. Objectives: We evaluated the anti-inflammatory and analgesic activity of Cleome brachycarpa and the effect of its extract on various hematological parameters, cholesterol levels, and liver enzymes to ensure the safe use of this natural product. Methods: Cleome brachycarpa was evaluated for its anti-inflammatory and analgesic effects at 200 mg/kg compared to diclofenic sodium and morphine, respectively. For anti-inflammatory activity, Wistar strain albino rats were pooled and divided into four groups: Negative control (normal saline), positive control (2% acetic acid), standard (Diclofenic sodium 10 mg/kg), and test (Cleome brachycarpa extract orally) groups for 10 days. For analgesic evaluation, mice were divided into control (normal saline), standard (morphine 10 mg/kg), and test (Cleome brachycarpa extract 200 mg/kg) groups and analyzed by the tail-flick method from zero to six hours. An assortment of blood parameters was evaluated, including white cells, red cells, hemoglobin level, hematocrit value, mean corpuscular volume, and mean corpuscular hemoglobin concentration. Besides, we computed the number of platelets, cholesterol, and enzyme (liver) level to ensure the safe use of this natural product. For this purpose, 60 rabbits were collected and divided into groups: Group A (control group) of 30 rabbits pooled without any treatment and Group B (treated group) of 30 rabbits receiving 200 mg/kg of Cleome brachycarpa. After 30 days, 4 mL blood sample was obtained by cardiac puncture. Results: Plethysmometer evaluation of anti-inflammatory effects showed maximum inflammatory inhibition of 29.42% at the sixth hour. Moreover, tail flick analysis showed maximum pain inhibition of 55.10% at the sixth hour, comparable to the standard drug. Furthermore, hematological data were analyzed statistically and showed insignificant results (P ≥ 0.05), indicating no prominent changes in hematological parameters, except for SGPT, a liver enzyme that increased after 30 days of treatment (P ≤ 0.05). Elevated levels of SGPT are usually reported with several drug administrations like NSAIDs and anti-TB drugs, but still, it should be further investigated. Conclusions: Cleome brachycarpa showed promising anti-inflammatory and analgesic effects without producing any potent change in enzymes except SGPT, which would be evaluated further.
Routes of Contamination and Risk Groups in Hepatitis B Virus (HBV) Infections-I
Authors: Cengiz A. Tevfik , Kıyan Mehmet , Uğurel M. Şahin , Özyedek Zeki , Özdöl Çağatay
Published: May 2023

In this article, routes of contamination of Hepatitis B Virus (HBV) infections and people under risk were examined. Meanwhile, the importance of HBV infections and facilitating factors for contamination are stressed. HBs Ag carriage and other important findings in staff working at health services are pointed.
Routes of Contamination and Risk Groups in Hepatitis B Virus (HBV) lnfections-II
Authors: Cengiz A. Tevfik , Kıyan Mehmet , Uğurel M. Şahin
Published: May 2023

In this article, blood receivers and donors are examined. Relation between HBs Ag carriage and effects of living in crawded populations, sexually transmission, parenteral drug dependence is investigated.
A Research Related to the Effects of Different lntensity DC Currents on Blood and Coagulation Parameters.
Authors: Erdal Nurten , Erdal M. Emin , Çelik Salih
Published: May 2023

Different intensity of DC currents is applied with different times and its effects are investigated on thrombin time which is one of the coagulation parameters. 0.25, 0.50 and 1 mA currents reduce the thrombin time according to the obtained results. Most reduction is observed at the value pf 0.50 mA. However it is determined that thrombin time is increased directly proportional with the intensity of the current for 2, 4 and 8 mA current values.
The Effect of Varicocele Grade on Sperm Quality
Authors: Yağcı Faruk , Erbağcı Ahmet , Sözduyar Nazım , Afşar Hamit
Published: May 2023

72 men with varicocele and/or infertility problem admited to our clinic since 3 year were examined for semen quality and the degree of varicocele. There are no significant relation between them: The quality of semen after operation was higher than before operation and it was statistically significant.
Fleksibl Fiberoptik Bronkoskopla Bilateral ve Periferik Yerleşimli Metalik Yabancı Cisim Çıkarılması
Authors: Ekinci Erhan , Filiz Ayten , Elbeyli Levent , Dikensoy Öner , Bulgur Didem
Published: May 2023

Nowadays and especially in our country, it is stili thought that rigid bronchoscope must be used for the removal of all kinds of aspirated foreign bodies in adults or children even if this process has a high risk of complications and it usually needs to be done under general anesthesia. Islamic faith requires women to cover their hair with a head scarf. This practice is more popular especially among young women. They use some kind of pins to attach this scarf. This pin has a coloured plastic little ball on the top and it is longer than the normal pins. in recent years, aspiration of this pin has been very frequent causing severe medical problems. A young wornen applied to our clinic with the same problem. On the postero-anterior chest roentgenogram of this patient, bilaterally placed two metallic foreign bodies were seen in the traceobronchial tree. Contrary to the comrnon beliPf, flexible fiberoptic bronchoscope was used for the removal of these foreign bodies. On the bronchoschopic examination revealed the head scarf pins in the medial segment of the right middle lobe and in the inferior lingula segment of left lung. Tips of the pins were located on the proximale and stuck to the bronchial wall. At first, the stuck tips of the pins were released from the wall of the bronchia with the help of dassic biopsy forceps. Then they were held diagonally by their tips using the forceps which pulled the pin up to the internal channel of bronchoscope. Then the bronchoscope was taken out gradually along with the forceps and the pin. This case report shows that bilateral and peripheric foreign bodies in the tracheabronchial tree can be removed by using flexible fiberoptic bronchoscope under the local anesthesia without any complications.
A Vase With Intercostal Schwannoma
Authors: Elbeyli Levent , Ergüler Erol
Published: May 2023

A male patient was admitted to the Department of Surgery for left chest pain and loca] mass at about 9 th costa. He was operated for this anterior axiller line mass. Solitary and encapsulated tumor and partially adjacent costa resected totaly. Histopathological diagnosis was intercostal schwannoma(neurilemoma). This case is reported and the literature reviewed in relation to the rarity of intercostal schwannomas.
Phosphodiesterase Inhibitors and Using in the Treatment of Congestive Heart Failure
Authors: Özcan Nurettin , Ural Uğur
Published: May 2023

Severe acute and chronic heart failure refractory to the conventional regimen continues to be a leading cause of cardiac mortality. Because depression of myocardial contractility is an important pathophysiological factor of heart failure and because the cardiac glycosides possess a low therapeutic value, intense interest is focused on other non-glycoside, non-sympathomimetic positive inotropic agents. These new cardiotonic agents increase the force of action of phosphodiesterase properties and clinical values.
A Massive Dentigerous Cyst in Maxillary Sinus
Authors:   Professor, Department of Oral and Maxillofacial Surgery, People Dental Academy, Bhopal, Jain Neha , Pillai Ajay K. ,   Professor and Head, Department of Oral and Maxillofacial Surgery, People Dental Academy, Bhopal.
Published: May 2023

The dentigerous cysts are odontogenic cysts associated with impacted or unerupted teeth and supernumerary teeth. This is a case report of a large dentigerous cyst encroaching maxillary sinus in a11-year-old female patient where the surgical enucleation was done.
Existence, multiplicity, perturbation, and concentration results for a class of quasi-linear elliptic problems
Authors: Squassina Marco
Published: May 2023

The aim of this monograph is to present a comprehensive survey of results about existence, multiplicity, perturbation from symmetry and concentration phenomena for a class of quasi-linear elliptic equations coming from functionals of the calculus of variations which turn out to be merely continuous. Some tools of non-smooth critical point theory will be employed.
algorithm for constructing Lyapunov functions
Authors: Hafstein Sigurdur Freyr Hafstein
Published: May 2023

In this monograph we develop an algorithm for constructing Lyapunov functions for arbitrary switched dynamical systems \(\dot{\mathbf{x}} = \mathbf{f}_\sigma(t,\mathbf{x})\), possessing a uniformly asymptotically stable equilibrium. Let \(\dot{\mathbf{x}}=\mathbf{f}_p(t,\mathbf{x})\), \(p\in \mathcal{P}\), be the collection of the ODEs, to which the switched system corresponds. The number of the vector fields \(\mathbf{f}_p\) on the right-hand side of the differential equation is assumed to be finite and we assume that their components \(f_{p,i}\) are \(\mathcal{C}^2\) functions and that we can give some bounds, not necessarily close, on their second-order partial derivatives. The inputs of the algorithm are solely a finite number of the function values of the vector fields \(\mathbf{f}_p\) and these bounds. The domain of the Lyapunov function constructed by the algorithm is only limited by the size of the equilibrium's region of attraction. Note, that the concept of a Lyapunov function for the arbitrary switched system \(\dot{\mathbf{x}} = \mathbf{f}_\sigma(t,\mathbf{x})\) is equivalent to the concept of a common Lyapunov function for the systems \(\dot{\mathbf{x}}=\mathbf{f}_p(t,\mathbf{x})\), \(p\in\mathcal{P}\), and that if \(\mathcal{P}\) contains exactly one element, then the switched system is just a usual ODE \(\dot{\mathbf{x}}=\mathbf{f}(t,\mathbf{x})\). We give numerous examples of Lyapunov functions constructed by our method at the end of this monograph.
INFLUENCE OF DIGESTION TEMPERATURE ON BIOGAS PRODUCTION FROM DISCARDED CASSAVA (
manihot esculenta) PEELS
Authors: Jauro M. S. , Aliyu B. , Abubakar A. J. , Umar M.
Published: May 2023

Anaerobic digestion is an established technology for treating different kinds of wastes and to simultaneously produce biogas (mixture of methane and carbon dioxide), which is useful and renewable energy source. In this work, the influence of temperature on the biogas production from cassava peels was studied in batch type anaerobic digesters of volume 500 ml at digestion temperatures of 35±5
0C, 45±5
0C and 55±5
0C for a retention period of 30 days. The quantity of the biogas produced daily were measured with a pressure gauge for the 30 days retention period and converted to volumetric gas yield. It was observed that the cumulative biogas yield increases by 25 % when the digestion temperature was raised from the mesophilic temperature range to thermophilic temperature range. The highest cumulative biogas yield of 289.33×10-5
m
3/kg-TS was obtained with the highest digestion temperature of 55±5
0C. It is therefore concluded that biogas production increases with the increase in digestion temperature and it is recommended that anaerobic digestion should be carried out at the thermophilic temperature range for better gas yield.
OPTIMIZATION OF BRIQUETTES PRODUCED FROM CARBONIZED COCONUT SHELL AND OIL PALM EMPTY FRUIT BUNCH BLENDS USING RESPONSE SURFACE METHODOLOGY
Authors: Gila L. M. , Abioye A. M. , Mohammed J.
Published: May 2023

In this study, briquettes were prepared from agricultural waste (coconut shell and oil palm empty fruit bunch) using cassava peels as binder. Central composite design (CCD) of response surface methodology (RSM) was used to investigate the effect of independent variables (binder amount, compaction force, and proportion of empty fruit bunch) on response variables (calorific value, compressive strength, burn rate and density). Conventional heating was adopted for the carbonization of both products: with coconut shell carbonized at 700
0C at 60 minutes residence time while OPEFB was carbonized at 400
0C at 30 minutes residence time. RSM analysis reveals that experimental results were best fitted into quadratic polynomial models. Optimized preparation conditions were compaction force 9kN, binder amount 50g and EFB:CS 80 % for 27.6151 MJ/kg calorific value, 2.85614 MPa compressive strength, 01.04378 g/min burning rate and 877.889 kg/m
3 density. These results were validated and found to be calorific value 27.97 MJ/kg, compressive strength 2.819 MPa, burning rate 1.025 g/min and density 896.32 kg/m
3 which justifies the predicted results. This study will be helpful for production of fuel alternatives for domestic uses in developing and underdeveloped countries.
UNITY AND DIVERSITY IN EUROPEAN CULTURE
Authors:   Politehnica University Timişoara, Constantin Elena Claudia
Published: May 2023

The author studies the role played by the national culture in the present day European cultural context. The European institutions have to solve, among other problems, the problem of European identity versus national identity. The findings show that the cultural dimension in the European Union is taken into consideration both by the Council of Europe and the European Commission and that different measures were taken to respect and to promote the diversity of European cultures, to bring the people of Europe together and to increase the sense of a European identity. The author analyses the cultural diversity in Banat, Romania, an example of the assimilation of the cultural values keeping at the same time its specific value and identity.
"DAS ZWISCHENSPIEL ZWISCHEN DEM BERSETZUNGSAUFTRAG UND DEM KOGNITIVEN SYSTEM DES ÜBERSETZERS "
Authors:   Politehnica University Timişoara, Icobescu Claudia
Published: May 2023

Der Übersetzungsprozess beginnt mit der Entgegennahme des Auftrags, heißt es. In dieser Arbeit wird dem Zwischenspiel einzelner Elemente des Übersetzungsauftrags und dem kognitiven Wissen des Übersetzers nachgegangen. Die der Übersetzungstätigkeit daraus erwachsenden Schwierigkeiten werden anhand von Beispielen aus dem Unterricht durchleuchtet.
Recruitment Management System
Authors:   Department of Computer Science and Engineering, V.S.B College of Engineering Technical Campus, Coimbatore, India., M Bala Logesh , S M Aadharsh , M Karthik , K Hari Haran , V Radha
Published: May 2023

The task is to develop a web-based application for a college's placement administration system. The college's placement office uses a web-based application created on the Windows platform to store student data in a database for companies to utilize during the recruitment process if they have the required login credentials. The system has all the relevant data about the students. In order to send a CV to an employer, the system saves all of the students' personal data as well as their technical skills. Institutions can utilise the system to manage student data and placement information. Students ought to have access to their accounts and be able to upload their assignments. This project helps students to keep track of their personal and academic information. It saves time by decreasing manual labor and reducing the amount of paper used Key Word: Management system, Connectivity, Dynamic Database, Wi-Fi.
Determination of wind loads on porous sunshade roof cover sheets using conversion factor
Authors: Vu Thanh Trung
Published: May 2023

Porous sunshade roof cover sheets installed on building roofs are new structures for mitigating heat absorption. Thus, there have been few studies on wind flow and its effects on wind-permeable structures, and there is no provision for these structures in the major international wind load standards and codes. Unlike wind loading on building roofs, wind loading on porous sunshade roof cover sheets is a combination of wind pressures on both the upper and lower surfaces, which complicates the calculation of wind loading. From the viewpoint of structural design, we need a simple method for determining wind loading on these structures. Wind tunnel tests have been carried out for various wind angles, three porosities (ratio between area of orifices and area of sheet), and five gaps between sheet and roof, and results have been analyzed. As a result, the author proposes a simple formula for calculating wind loading on porous sunshade roof cover sheets from wind loadings on normal building roofs available from wind loading codes and standards. The calculated results based on this formula and the Japanese wind loading standard (AIJ-RFLB (2015))[4] are compared with those of wind tunnel tests. There is a good similarity between them.
A comparative investigation using artificial neural network (ANN) and decision tree (DT) methods in the prediction of slump and strength for concrete samples
Authors: Vu Van Tuan
Published: May 2023

In the past few years, the application of Machine Learning Techniques (MLT) has become a popular way to enhance the accuracy of predicting concrete properties. This study aims to compare and contrast the performance of Artificial neural network (ANN) and Decision Tree (DT) methods in predicting the compressive strength and slump values of concrete samples. Experimental data used for model building and comparison were obtained from a previous research project. R-squared value (RSQ) and Mean Squared Error (MSE) metrics were used to determine which regression method was the most efficient in predicting concrete compressive strength and slump values. The results from the comparison between ANN and DT methods would be able to identify which of the two regression models is the better choice for forecasting concrete properties.
Calidad en la educación superior en la OCDE. Una revisión sistemática
Authors: Verástegui Velásquez Graciela Soledad
Published: May 2023

La investigación tiene como finalidad, hacer un análisis crítico sobre la calidad en la educación superior, en países de América pertenecientes a la OCDE, tomando en cuenta artículos publicados en revistas indexadas tal como: Scopus, Web of Science y Scielo. Debido a que, la calidad en la educación superior es un tema que hoy en día a nivel internacional, preocupa a las universidades de ser capaces en formar a futuros profesionales de calidad, que contribuyan en el desarrollo de su país, lograr este propósito implica el involucramiento del Estado e instituciones que regulan los lineamientos en educación, por lo tanto, deben generar conciencia de ajustar los sistemas nacionales, internacionales, a las necesidades reales de cada país, con una cultura de calidad integral u holística que toda institución educativa ambiciona. Los años considerados de la información adquirida fueron del 2017 al 2022. Se desarrolló en un enfoque cuantitativo, siendo el tipo de investigación descriptivo, además, se optó por revisar 50 artículos y 3 bases teóricas relevantes para la investigación.
ISSUES OF STRATEGIC ACCOUNTING FOR SUSTAINABLE DEVELOPMENT OF ENTERPRISES
Authors: Abesadze Otar , Martirosyan Gevorg
Published: May 2023

Information users are currently interested in the results of entrepreneurial activity not only in terms of financial, but also non-financial achievements. Along with the traditional financial reports, it is proposed to publish reports on the results of the sustainable development of enterprises.

The article presents suggestions for improving the methodology of strategic accounting for sustainable development of enterprises․ In particular, new management accounts and double registration correspondence were proposed, through which the strategic results of sustainable development of enterprises are recorded.
Persamaan Medan Einstein Efektif untuk Ruang-Waktu 5D Kaluza-Klein
Authors: Latief Muh Fachrul , Ramadani A Indra Wulan Sari
Published: May 2023

Dalam studi ini, telah ditelaah kembali persamaan medan Einstein yang efektif untuk ruang-waktu 5D dalam teori Kaluza Klein. Teori Kaluza-Klein merupakan teori yang menggabungkan gaya gravitasi dengan gaya elektromagnetik secara klasik dalam dimensi ruang-waktu (4d + 1). Studi lebih difokuskan pada perumusan medan Einstein untuk metrik Kaluza-Klein, ungkapan simbol Christoffel yang tidak bernilai nol, ungkapan tensor Ricci yang tidak nol, ungkapan kelengkungan skalar dari geometri ruang-waktu 5D, serta  ungkapan tensor Einstein untuk ruang-waktu 5D. Penjabaran ini dibatasi sampai pada kasus vakum yang dapat direduksi menjadi persamaan medan Einstein 4D sehingga memberikan makna fisis. Hasil yang diperoleh merupakan tinjauan klasik, yakni adanya kelengkungan ruang-waktu akibat hadirnya kopling antara medan elektromagnet dan medan skalar terhadap gravitasi yang dijelaskan melalui persamaan medan Einstein. Yang di mana medan elektromagnetik juga bergantung pada medan skalarnya.
El emprendimiento y su desarrollo desde la perspectiva universitaria
Authors: García Mayra , Hurtado Ketty , Torres Rosa , Díaz Pedro
Published: May 2023

l contexto actual, existe la necesidad de superar los constantes y crecientes problemas que afectan a los diferentes sectores. Es así que los emprendimientos son importantes en el ámbito micro empresarial y académico, debido a su relevante impacto en el desarrollo económico y social de los países. Desafortunadamente, en este marco, se sufre el desconocimiento del perfil emprendedor en el estudiante universitario. Esto ocasiona que, los recursos económicos destinados a financiar el emprendimiento universitario, no se asignen eficientemente, además del desperdicio de esfuerzos que podrían generar nuevos negocios populares. Este trabajo se propone exponer algunos elementos del emprendimiento y su desarrollo desde la perspectiva universitaria en el cantón La Maná. Los emprendimientos, dentro de este cantón, necesitan de recursos para nuevos proyectos, nuevos retos innovadores que agreguen valor a sus productos. En este sentido, estos deben demostrar en el mercado capacidad para anticiparse a nuevas tendencias y prever posibles nichos económicos o socioculturales relacionados con su actividad. Los emprendimientos atacan los problemas que surgen de las necesidades de las comunidades en lo social, económico y cultural, permitiendo alcanzar mayores logros en beneficio de la colectividad. Se concluye que la formación de estudiantes universitarios con capacidad de crear empresas, involucrará sus conocimientos con el desarrollo económico de la región. Esto reflejará su aporte en la creación de empleos sostenibles en los sectores económicos del entorno. Es así que el emprendimiento tiene sus ventajas: primero, genera ingresos a los hogares y empleos en la comunidad; posteriormente, permite al individuo ser independiente y, por lo tanto, manejar su tiempo, espacio y tomar sus propias decisiones.
Experiencias educativas y su impacto en el aprendizaje en tiempos de COVID y POS-COVID
Authors: Vaca Cerda Telmo Edwin , Chiluisa Chiluisa Marcia Janeth , Cayo Lema Efraín Luis , Barbosa Zapata José Nicolás , Cajas Cayo Isaac Eduardo
Published: May 2023

El presente trabajo muestra el impacto y las experiencias relacionadas con el proceso de Vinculación con la Sociedad, en la época de emergencia sanitaria ocasionada por el COVID-19. Además, contrasta dichos resultados con el posterior periodo post COVID. En este sentido, se exponen las actividades realizadas en entornos virtuales y los resultados de la aplicación de nuevas estrategias metodológicas y pedagógicas en los beneficiarios. También, fue necesario introducir herramientas innovadoras de enseñanza - aprendizaje, que permitan adaptarse al nuevo entorno virtual y su impacto en la post pandemia.
Propuesta de indicadores de evaluación de impactos de los proyectos de vinculación con la sociedad
Authors: Castillo de la Guerra Cléver Gilberto , Jácome Mogro Emerson Javier , Jiménez Jácome Cristian Santiago , Marín Quevedo Karina Paola
Published: May 2023

El propósito de esta investigación fue buscar un método que permita evaluar los impactos de los proyectos de Vinculación con la sociedad de la Facultad de Ciencias Agropecuarias y Recursos Naturales (CAREN) de la Universidad Técnica de Cotopaxi (UTC), en los sectores priorizados donde fueron implementados. Para ello, se estableció una lista de indicadores fundamentados en criterios económicos, ambientales y socio-culturales que respondan a la realidad concreta del sector en intervención. Los resultados demuestran que el método de Sarandón se basa en los criterios establecidos para este tipo de evaluación de impactos, ya que permite establecer criterios económicos, ambientales, socioculturales. Estos criterios permiten cuantificar el impacto del proyecto a través de escalas numéricas, dando como resultados índices cuantificables.
Implementación de aplicaciones móviles multiplataforma para las MiPymes de la provincia de Cotopaxi
Authors: Quisaguano Collaguazo Luis René , Martínez Freire Maira Natalia , Pallasco Venegas Mirian Susana
Published: May 2023

Las aplicaciones para dispositivos móviles son la gran revolución que las MiPymes tienen a su alcance para llegar a sus clientes. Su uso está creciendo cada día más, como una gran oportunidad de las empresas para realizar un marketing eficaz. Las aplicaciones móviles tienen la gran ventaja de poder entrar en contacto con el cliente, en cualquier lugar y momento del día. No es necesario que la empresa o tienda esté abierta para que esto suceda. Las aplicaciones permiten a las Pymes incrementar sus beneficios, pero para esto es importante crear una estrategia de marketing móvil adecuada para el negocio. Latacunga tiene empresas de actividades agropecuarias, extractivas, comerciales y de servicio con auge productivo y comercial. No obstante, en la provincia de Cotopaxi existe un bajo nivel de uso de aplicaciones móviles, para la gestión de transacciones de ventas, compras y pagos, a pesar que las tecnologías han avanzado de manera considerable. Las MiPymes pueden ser un campo muy amplio, es por ello que, a través del método deductivo, se ha podido establecer componentes fundamentales a considerar por una microempresa, cuando busque incorporar este tipo de estrategias dentro de la organización.
El significado de persona frente al significado de cosa en el contexto del complemento directo. Propuesta didáctica en el aula de ELE
Authors: Méndez Guerra Sara María
Published: May 2023

Este trabajo tiene como objetivo desarrollar el estudio de los recursos sintácticos necesarios para expresar la noción de persona concreta en español en el contexto del complemento directo, con el fin de llevar a cabo una propuesta didáctica para el aula de ELE. Este significado (quiero a mis hijos) se opone al de perfil o clase (quiero hijos) que también transmiten los sustantivos animados. La diferencia semántica, esencial para lograr la competencia comunicativa, procede de la combinación del sustantivo con determinados recursos sintácticos, especialmente con ciertos determinantes y con la preposición a. En este planteamiento, se tiene en cuenta el principio de que los contenidos gramaticales de la clase de ELE deben situarse en el ámbito de la enseñanza comunicativa y de que el enfoque, la metodología, los materiales y los recursos didácticos deben orientarse al servicio de los intereses y necesidades del alumnado.
La lengua poética de Luis Alberto de Cuenca. del mito a los novísimos
Authors: Alonso Fernández Ana María
Published: May 2023

Luis Alberto de Cuenca pertenece a la llamada segunda generación de los novísimos, grupo poético caracterizado por el alejamiento de la poesía social, la metapoesía y el culturalismo, es decir, la introducción en los poemas de referencias a otras artes, incluyendo el cine, los medios de comunicación o el cómic. Uno de los ejes centrales de los novísimos es la escritura poética, la capacidad del lenguaje para expresar la realidad. Por su filiación clásica (como especialista, investigador y traductor de textos griegos y latinos) la poesía de Luis Alberto de Cuenca contiene referencias a mitos y rasgos estilísticos también clásicos que adapta a su mundo lírico, cuyos núcleos temáticos son el desengaño y el fracaso amoroso, el escenario urbano, el sexo descarnado, el cinismo y el pesimismo. La antología Hola, mi amor, yo soy el lobo y otros poemas de Romanticismo feroz (2016) es una buena muestra de la lengua poética del autor a través de sus diferentes etapas.
KONSEP ISTIQAMAH DALAM PERSPEKTIF AL-QUR’AN
Authors: Shofiuddin Shofiuddin , Thohari Muh Hamim
Published: May 2023

Penelitian ini berjudul konsep istiqamah dalam perspektif al-Qur’an (kajian tafsir tematik terhadap ayat-ayat istiqamah). Penelitian ini berusaha menguraikan beberapa penafsiran istiqamah menurut para mufassir atau dalam kata lain untuk mengetahui dan mengkaji konsep istiqamah secara mendalam sesuai dengan tuntunan agama dan syariat Allah SWT. Penelitian ini merupakan kajian studi kepustakaan (library research) yang bersifat deskriptif-analisis dengan langkah-langkahnya meliputi penyusunan data dan penafsiran data atau menguraikannya secara sistematis terhadap sebuah konsep atau antar konsep, dengan menggunakan motode kajian tafsir tematik. Adapun hasil dari penelitian menunjukkan bahwa ada beberapa konsep istiqamah dalam al-Qur’an, Pertama istiqamah janji. Kedua istiqomah do’a, Ketiga istiqamah dalam perintah. Keempat istiqamah dalam tauhid. Kelima istiqamah dalam berdakwah. Keenam istiqamah dalam jalan agama.
Effect of service quality dimensions on customer satisfaction at the Nikisa Body Repair Workshop in Malang
Authors: Ramadhani Ardhi
Published: May 2023

This type of research is explanatory research, namely explaining the relationship between research variables and testing the hypotheses that have been formulated previously. The background for taking the title in this study is the fairly tight competition in the four-wheeled vehicle maintenance service business, which causes the NIKISA BODY REPAIR workshop to have an advantage in winning the competition. Excellence can be realized, one of which is by improving the quality of service from the NIKISA BODY REPAIR workshop so that consumer satisfaction can be realized. The purpose of this study was to determine the effect of service quality dimensions on customer satisfaction at NIKISA BODY REPAIR workshops, and to determine which service quality dimension factors most dominantly influence satisfaction at NIKISA BODY REPAIR workshops in Malang. The research method used was a sample population by distributing questionnaires to predetermined respondents (purposive sampling) to obtain research data. The data analysis used is using statistical methods such as multiple linear regression, F test, t test, to test the determined hypothesis. Based on the theoretical study used, the authors draw a hypothesis. Hypothesis I where there is significant influence simultaneously and partially between service quality dimension variables such as Physical Evidence (X1), Reliability (X2), Responsiveness (X3), Assurance (X3), and Empathy (X5) to customer satisfaction variables (Y1). And the second hypothesis is suspected that the empathy variable (X5) has a dominant influence on the Customer Satisfaction variable (Y1) compared to the other four variables. From the processed data, the resulting variable dimensions of service quality have a significant effect on customer satisfaction either partially or simultaneously. And the variable dimension of service quality that has a dominant influence on customer satisfaction is the variable Empathy (X5).
Analysis of selling price setting mechanisms and services in the perspective of Islamic economics (Case study of photocopying and printing Ammey Kel. Dermayu Kab. Seluma Prov. Bengkulu)
Authors: Muslihatun Siti
Published: May 2023

The purpose of this study was to find out how the mechanism for setting selling prices and services for Photocopying and Printing Ammey Kel. Dermayu Kab. Selum Prov. Bengkulu and to find out how the Islamic economic review of the mechanism for setting selling prices and services on Ammey's Photocopying and Printing. To reveal this issue in depth and comprehensively, the authors used qualitative methods to collect the information needed during the research period. The data collection for this research was carried out by conducting observations or observations and interviews, with research objects at Ammey Photocopying and Printing. using fairness-based pricing, the pricing at Ammey Photocopying and Printing is in accordance with Islamic economic principles because the prices set do not tyrannize the buyer, namely Ammey Photocopying and Printing take advantage of the interest rate horse. Photocopying and Printing Ammey does not take advantage of the round off price, but the rest of the round off will be collected and diverted to social funds and to the mosque's charity box. and the determination of price rounding is a balance point between the forces of supply and demand which are agreed voluntarily and voluntarily by sellers and buyers.
IMPLEMENTATION OF GROUP GUIDANCE WITH GROUP DISCUSSION TECHNIQUES TO INCREASE LEARNING INTEREST OF STUDENTS SMAN 1 SUSUT
Authors: Dartiningsih Made Wery , Anggareni Ni Luh Trisna
Published: May 2023

This study aims to determine the application of group guidance using group discussion techniques to increase the learning interest of grade XII Language 3 students at SMAN 1 Susut in the academic year 2022/2023. This research includes Classroom Action Research, an effort carried out in a planned and systematic way by reflecting on service practices and then carrying out corrective actions to improve counseling service practices. The subjects of this study were students of class XII Language 3 SMAN 1 Susut who were selected for one class that showed a problem regarding low interest in learning, which was determined based on data from the guidance and counseling teacher as well as direct observation of the researcher, then through the interest in learning instrument it was found that five students became research subject. The results of this study indicate that group counseling services with group discussion techniques are very effective and can increase students' interest in learning by 73.8%. The researchers suggest counseling guidance teachers can use group guidance services with group discussion techniques as an appropriate alternative to address student problems, significantly increasing student interest in learning at SMAN 1 Susut.
pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells
Authors: Farahani Payam E , Yang Xiaoyu , Mesev Emily V , Fomby Kaylan A , Brumbaugh-Reed Ellen H , Bashor Caleb J , Nelson Celeste M , Toettcher Jared E
Published: May 2023

Receptor tyrosine kinases (RTKs) are major signaling hubs in metazoans, playing crucial roles in cell proliferation, migration, and differentiation. However, few tools are available to measure the activity of a specific RTK in individual living cells. Here, we present pYtags, a modular approach for monitoring the activity of a user-defined RTK by live-cell microscopy. pYtags consist of an RTK modified with a tyrosine activation motif that, when phosphorylated, recruits a fluorescently labeled tandem SH2 domain with high specificity. We show that pYtags enable the monitoring of a specific RTK on seconds-to-minutes time scales and across subcellular and multicellular length scales. Using a pYtag biosensor for epidermal growth factor receptor (EGFR), we quantitatively characterize how signaling dynamics vary with the identity and dose of activating ligand. We show that orthogonal pYtags can be used to monitor the dynamics of EGFR and ErbB2 activity in the same cell, revealing distinct phases of activation for each RTK. The specificity and modularity of pYtags open the door to robust biosensors of multiple tyrosine kinases and may enable engineering of synthetic receptors with orthogonal response programs.
RANK+TLR2+ myeloid subpopulation converts autoimmune to joint destruction in rheumatoid arthritis
Authors: Zhang Weixin , Noller Kathleen , Crane Janet , Wan Mei , Wu Xiaojun , Cahan Patrick , Cao Xu
Published: May 2023

Joint destruction is the major clinic burden in patients with rheumatoid arthritis (RA). It is unclear, though, how this autoimmune disease progresses to the point of deterioration of the joint. Here, we report that in a mouse model of RA the upregulation of TLR2 expression and its α(2,3) sialylation in RANK+ myeloid monocytes mediate the transition from autoimmunity to osteoclast fusion and bone resorption, resulting in joint destruction. The expression of α(2,3) sialyltransferases was significantly increased in RANK+TLR2+ myeloid monocytes, and their inhibition or treatment with a TLR2 inhibitor blocked osteoclast fusion. Notably, analysis of our single-cell RNA-sequencing (scRNA-seq) libraries generated from RA mice revealed a novel RANK+TLR2− a subset that negatively regulated osteoclast fusion. Importantly, the RANK+TLR2+ subset was significantly diminished with the treatments, whereas the RANK+TLR2− subset was expanded. Moreover, the RANK+TLR2− subset could differentiate into a TRAP+ osteoclast lineage, but the resulting cells did not fuse to form osteoclasts. Our scRNA-seq data showed that Maf is highly expressed in the RANK+TLR2− subset, and the α(2,3) sialyltransferase inhibitor-induced Maf expression in the RANK+TLR2+ subset. The identification of a RANK+TLR2− subset provides a potential explanation for TRAP+ mononuclear cells in bone and their anabolic activity. Further, TLR2 expression and its α(2,3) sialylation in the RANK+ myeloid monocytes could be effective targets to prevent autoimmune-mediated joint destruction.
Multiple repeat regions within mouse DUX recruit chromatin regulators to facilitate an embryonic gene expression program
Authors: Smith Christina M. , Grow Edward J. , Shadle Sean C. , Cairns Bradley R.
Published: May 2023

The embryonic transcription factor DUX regulates chromatin opening and gene expression in totipotent cleavage-stage mouse embryos, and its expression in embryonic stem cells promotes their conversion to 2-cell embryo-like cells (2CLCs) with extraembryonic potential. However, little is known regarding which domains within mouse DUX interact with particular chromatin and transcription regulators. Here, we reveal that the C-terminus of mouse DUX contains five uncharacterized ∼100 amino acid (aa) repeats followed by an acidic 14 amino acid tail. Unexpectedly, structure-function approaches classify two repeats as ‘active’ and three as ‘inactive’ in cleavage/2CLC transcription program enhancement, with differences narrowed to a key 6 amino acid section. Our proximity dependent biotin ligation (BioID) approach identified factors selectively associated with active DUX repeat derivatives (including the 14aa ‘tail’), including transcription and chromatin factors such as SWI/SNF (BAF) complex, as well as nucleolar factors that have been previously implicated in regulating the Dux locus. Finally, our mechanistic studies reveal cooperativity between DUX active repeats and the acidic tail in cofactor recruitment, DUX target opening, and transcription. Taken together, we provide several new insights into DUX structure-function, and mechanisms of chromatin and gene regulation.
Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange
Authors: Tippett David N. , Breen Colum , Butler Stephen J. , Sawicka Marta , Dutzler Raimund
Published: May 2023

Members of the SLC26 family constitute a conserved class of anion transport proteins, which encompasses uncoupled transporters with channel-like properties, coupled exchangers and motor proteins. Among the ten functional paralogs in humans, several participate in the secretion of bicarbonate in exchange with chloride and thus play an important role in maintaining pH homeostasis. Previously, we have elucidated the structure of murine SLC26A9 and defined its function as an uncoupled chloride transporter (Walter, Sawicka, & Dutzler, 2019). Here we have determined the structure of the closely related human transporter SLC26A6 and characterized it as a coupled exchanger of chloride with bicarbonate and presumably also oxalate. The structure defines an inward-facing conformation of the protein that generally resembles known structures of SLC26A9. The altered anion selectivity between both paralogs is a consequence of a remodeled ion binding site located in the center of a mobile unit of the membrane-inserted domain, which also accounts for differences in the coupling mechanism.
Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ
Authors: Tan Zhi Yang , Cai Shujun , Noble Alex J. , Chen Jon K. , Shi Jian , Gan Lu
Published: May 2023

Nuclear processes depend on the organization of chromatin, whose basic units are cylinder-shaped complexes called nucleosomes. A subset of mammalian nucleosomes
in situ
(inside cells) resembles the canonical structure determined
in vitro
25 years ago. Nucleosome structure
in situ
is otherwise poorly understood. Using cryo-ET and 3-D classification analysis of yeast cells, here we find that canonical nucleosomes account for less than 10% of total nucleosomes expected
in situ
. In a strain in which H2A-GFP is the sole source of histone H2A, class averages that resemble canonical nucleosomes both with and without an extra density are found
ex vivo
, but not
in situ
. These data suggest that the yeast intranuclear environment favors multiple non-canonical nucleosome conformations. Using the structural observations here and the results of previous genomics and biochemical studies, we propose a model in which the average yeast nucleosome’s DNA is partially detached
in situ
.
Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis
Authors: Watanuki Shintaro , Kobayashi Hiroshi , Sugiura Yuki , Yamamoto Masamichi , Karigane Daiki , Shiroshita Kohei , Sorimachi Yuriko , Fujita Shinya , Morikawa Takayuki , Koide Shuhei , Oshima Motohiko , Nishiyama Akira , Murakami Koichi , Haraguchi Miho , Tamaki Shinpei , Yamamoto Takehiro , Yabushita Tomohiro , Tanaka Yosuke , Nagamatsu Go , Honda Hiroaki , Okamoto Shinichiro , Goda Nobuhito , Tamura Tomohiko , Nakamura-Ishizu Ayako , Suematsu Makoto , Iwama Atsushi , Suda Toshio , Takubo Keiyo
Published: May 2023

Metabolic pathways are plastic and rapidly change in response to stress or perturbation. Current metabolic profiling techniques require lysis of many cells, complicating the tracking of metabolic changes over time after stress in rare cells such as hematopoietic stem cells (HSCs). Here, we aimed to identify the key metabolic enzymes that define differences in glycolytic metabolism between steady-state and stress conditions in murine HSCs and elucidate their regulatory mechanisms. Through quantitative 13C metabolic flux analysis of glucose metabolism using high-sensitivity glucose tracing and mathematical modeling, we found that HSCs activate the glycolytic rate-limiting enzyme phosphofructokinase (PFK) during proliferation and oxidative phosphorylation (OXPHOS) inhibition. Real-time measurement of ATP levels in single HSCs demonstrated that proliferative stress or OXPHOS inhibition led to accelerated glycolysis via increased activity of PFKFB3, the enzyme regulating an allosteric PFK activator, within seconds to meet ATP requirements. Furthermore, varying stresses differentially activated PFKFB3 via PRMT1-dependent methylation during proliferative stress and via AMPK-dependent phosphorylation during OXPHOS inhibition. Overexpression of Pfkfb3 induced HSC proliferation and promoted differentiated cell production, whereas inhibition or loss of Pfkfb3 suppressed them. This study reveals the flexible and multilayered regulation of HSC glycolytic metabolism to sustain hematopoiesis under stress and provides techniques to better understand the physiological metabolism of rare hematopoietic cells.
Ritual Renewal and Spatiotemporal Fusion
Authors: Trémon Anne-Christine
Published: May 2023

This chapter examines the diasporic relationship through the lens of ritual. It traces how the revival of ancestor worship from 1981 was actually its relocalization, since its practice was moved overseas during the period when it was prohibited on the mainland. The way in which the rituals are performed today is the outcome of negotiation between the villagers and Hong Kongers. The chapter looks at how the rituals accomplish the fusion of spatiotemporally distant kin and simultaneously display tensions and differentiation. The symbolic association of the diaspora with the past is very visible in the ways the villagers contrast their overseas.
Saving Medications versus Saving Children
Authors: Brada Betsey Behr
Published: May 2023

This chapter examines how the Superlative Clinic's pediatricians assessed whether children were taking their antiretrovirals (ARVs). When pediatricians concluded that a child's adherence was inconsistent, they had to decide whether to confiscate the child's ARVs in a bid to preserve their long-term efficacy. By focusing on the ways pediatricians scaled pediatric HIV treatment, the chapter shows how the uncertainties immanent in assessments could cast doubt on the broader project of HIV treatment. It highlights the pediatricians' interest in preserving the efficacy of ARVs that could place the lives of individual children at risk. It also discusses adherence assessments, the processes by which Clinic staff determined whether children were taking their medications as directed.
How to Do Things to Children with Words
Authors: Brada Betsey Behr
Published: May 2023

This chapter talks about the problem of adherence that shaped how pediatricians taught children to talk about HIV. Concerned that children's families concealed their diagnoses from them, pediatricians stressed the need for transparency as a precondition for children's ongoing adherence and their very survival. The chapter highlights the pediatricians' conviction that the word AIDS impaired children's ability to acknowledge their infections and adhere to treatment. The word AIDS lead them to silent representations of HIV as anything other than a manageable condition readily controlled by diligent children. The chapter describes the pediatricians' anxious efforts to shape children through speech informed by visions of catastrophe that could only be forestalled one child at a time.
Experiencing AIDS in Africa
Authors: Brada Betsey Behr
Published: May 2023

The chapter looks more closely at the profound moral transformation Americans expected from global health as an embodied experience. Focusing on the register of heroic American medicine, it shows how Eastern University Medical School (EUMS) personnel attempted to frame mere physical proximity violence into moments that revealed and affirmed their moral rectitude. It also contrasts Americans' longings for moments with the perspectives of the ward's young Batswana medical officers, who regarded their own medical expertise as a means of aligning themselves with their patients in a project of national progress. The chapter looks at the promised transformations of global health pedagogies as a fantasy grounded in institutional and national inequalities. It examines the ideological framework that grounds the fantasy of transformative encounters that global health pedagogies promise to students.