bluuebunny/crossref_metadata_2025 huggingface dataset:
The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia
Authors: Fritz Josef , Brozek Wolfgang , Concin Hans , Nagel Gabriele , Kerschbaum Julia , Lhotta Karl , Ulmer Hanno , Zitt Emanuel
Published: May 2022

Significance Statement

Insulin resistance, hypertension, hyperuricemia, and hypercholesterolemia are candidates for mediating the effect of BMI on ESKD. However, the independent contributions of these factors have not been quantified in prospective studies to date. Applying a model of mediation, the authors quantified the contribution of these four metabolic factors to the association of BMI with ESKD in a population-based cohort of 100,269 predominantly healthy Austrian individuals. They found that the association of BMI with ESKD was mediated through TyG index (a measure of insulin resistance), mean arterial pressure, and uric acid, but not through total cholesterol. The findings suggest that in addition to weight reduction, the control of metabolic risk factors is important in mitigating the adverse effects of BMI on kidney function.

Background

Insulin resistance, hypertension, hyperuricemia, and hypercholesterolemia are hypothesized to be important intermediates in the relationship between excess body weight and CKD risk. However, the magnitude of the total effect of excess body weight on ESKD mediated through these four pathways remains to be quantified.

Methods

We applied a model for analysis of correlated mediators to population-based data from 100,269 Austrian individuals (mean age 46.4 years). Association of body mass index (BMI) was coalesced with ESKD risk into direct association. Indirect associations were mediated through the triglyceride-glucose (TyG) index (as an indicator of insulin resistance), mean arterial pressure (MAP), uric acid (UA), and total cholesterol (TC).

Results

Mean follow-up was 23.1 years with 463 (0.5%) incident ESKD cases. An unhealthy metabolic profile (prevalence 32.4%) was associated with a markedly increased ESKD risk (multivariably adjusted hazard ratio (aHR), 3.57; 95% CI, 2.89 to 4.40), independent of BMI. A 5-kg/m2 higher BMI was associated with a 57% increased ESKD risk (aHRtotal association, 1.57; 1.38 to 1.77). Of this association, 99% (76% to 140%) arose from all mediators jointly; 33% (22% to 49%) through TyG index; 34% (24% to 50%) through MAP; 30% (21% to 45%) through UA; and 2% (−1% to 4%) through TC. The remaining direct association was nonsignificant (aHRdirect association, 1.01; 0.88 to 1.14).

Conclusions

TyG index, MAP, and UA, but not TC, mediate the association of BMI with ESKD in middle-aged adults. Our findings highlight that in addition to weight reduction, the control of metabolic risk factors might be essential in mitigating the adverse effects of BMI on kidney function.
EDUCAÇÃO A DISTÂNCIA, MÉTODOS E TECNOLOGIAS EM PROJETO DE FORMAÇÃO COMPLEMENTAR COM JOVENS: O CASE JUVENTUDE CONECTADA
Authors:   CRESOL, PANZER LUIZ ADEMAR , VANDRESEN JOSÉ CARLOS ,   CRESOL INSTITUTO, DALACOSTA ROSIANE ,   CRESOL INSTITUTO, FONTANA JOSÉ AUGUSTO ,   CRESOL INSTITUTO, BALDISSERA HELEM CRISTINA ,   CRESOL INSTITUTO
Published: May 2022

A EDUCAÇÃO A DISTÂNCIA (EAD) É UM MODELO DE ENSINO HÁ MUITO DISCUTIDO NOS DIFERENTES CONTEXTOS EDUCACIONAIS, COM NOTÁVEL EXPANSÃO DE SUA UTILIZAÇÃO A PARTIR DO ADVENTO DA PANDEMIA DA COVID-19. FRENTE A ESTA ASSERTIVA, O PRESENTE TRABALHO OBJETIVOU RELATAR A EXPERIÊNCIA DO PROJETO JUVENTUDE CONECTADA, DESENVOLVIDO POR UMA INSTITUIÇÃO FINANCEIRA COOPERATIVA E QUE EVIDENCIA SEU COMPROMISSO COM OS PRINCÍPIOS COOPERATIVISTAS COM A PESSOAS E AS COMUNIDADES. O PROJETO TEVE A PARTICIPAÇÃO DE 249 JOVENS, COM IDADE ENTRE 16 A 25 ANOS, E CONTOU COM DIVERSIFICADOS RECURSOS DIDÁTICOS E METODOLÓGICOS, ESTRATÉGIAS DE GAMIFICAÇÃO E UTILIZAÇÃO DE REDES SOCIAIS PARA APRENDIZAGEM, COM DURAÇÃO DE 20 SEMANAS E TOTALIZANDO UMA CARGA HORÁRIA DE 110 HORAS. DESTACA-SE QUE A POSSIBILIDADE DE EXECUÇÃO DE UM PROJETO COMO O RELATADO NESTE TRABALHO, SÓ FOI POSSÍVEL COM A ADOÇÃO DO MODELO DE EAD, O QUE TAMBÉM POTENCIALIZOU O SEU ALCANCE, CHEGANDO A JOVENS DE 14 ESTADOS BRASILEIROS, SENDO ASSIM POSSÍVEL, CONTRIBUIR COM A FORMAÇÃO COMPLEMENTAR DOS PARTICIPANTES A PARTIR DE TEMÁTICAS VOLTADAS À EDUCAÇÃO COOPERATIVISTA, EDUCAÇÃO FINANCEIRA E DESENVOLVIMENTO PROFISSIONAL. O RELATO APRESENTOU A CONCEPÇÃO DO PROJETO JUVENTUDE CONECTADA PARA O MODELO DE EAD E A AVALIAÇÃO DA SATISFAÇÃO DOS JOVENS PARTICIPANTES, COMPARTILHANDO TAMBÉM OS VARIADOS RECURSOS UTILIZADOS PARA A APRENDIZAGEM E VIVÊNCIA DOS JOVENS DURANTE O PROJETO
O ENSINO REMOTO E AS MUDANÇAS NO FAZER PEDAGÓGICO DO PROFESSOR: AÇÕES INOVADORAS PARA DESPERTAR A CRIATIVIDADE
Authors:   CENTRO UNIVERSITÁRIO INTERNACIONAL UNINTER, PAULA ALESSANDRA DE , CEGAN EDILAINE ,   CENTRO UNIVERSITÁRIO INTERNACIONAL UNINTER, HERGINZER PALOMA ,   CENTRO UNIVERSITÁRIO INTERNACIONAL UNINTER, SELEME ROBSON ,   UNIVERSIDADE FEDERAL DO PARANÁ
Published: May 2022

A PANDEMIA EXIGIU MUDANÇAS NA FORMA DE MINISTRAR AULAS E, PARA VERIFICAR COMO AS AULAS ESTÃO SENDO REALIZADAS EM UMA IES QUE OFERECE CURSOS NAS MODALIDADES A DISTÂNCIA, PRESENCIAIS E SEMIPRESENCIAIS, FEZ-SE UMA PESQUISA QUALITATIVA, APLICADA, DE CARÁTER EXPLORATÓRIO, PARA VERIFICAR COMO FOI FEITA A ADEQUAÇÃO DE METODOLOGIAS E ESTRATÉGIAS, PELOS PROFESSORES. DE ACORDO COM OS PRESSUPOSTOS TEÓRICOS QUE DEFENDEM A EDUCAÇÃO COMO RECURSO PARA A CONQUISTA DA INDEPENDÊNCIA E ACESSO À CIDADANIA, O ENSINO DEVE PRIVILEGIAR A ANÁLISE, A REFLEXÃO E A CRÍTICA, BEM COMO FAVORECER O DESENVOLVIMENTO E A CRIATIVIDADE. OS RESULTADOS APONTAM QUE GRANDE PARTE DOS PROFESSORES DA IES BUSCAM REALIZAR ATIVIDADES QUE CONTRIBUAM PARA DESPERTAR A CRIATVIDADE,EMBORA HAJA ALGUNS QUE AINDA SÃO RESISTENTES A MUDANÇAS E INOVAÇÕES
MODELO DE CURADORIA DE CONTEÚDO E SUA REPRESENTATIVIDADE PEDAGÓGICA E TECNOLÓGICA NA EAD
Authors:   UNIVERSIDADE FERNANDO PESSOA, ROCHA DAIANA GARIBALDI DA , GOUVEIA LUIS MANUEL BORGES ,   UNIVERSIDADE FERNANDO PESSOA
Published: May 2022

EM DECORRÊNCIA DA PANDEMIA DE COVID-19, PROFESSORES DE TODAS AS ÁREAS DO CONHECIMENTO NECESSITARAM SE ADAPTAR AO ENSINO NÃO PRESENCIAL E PRATICAR DE MANEIRA MAIS AUTÔNOMA A CURADORIA DE CONTEÚDO. O OBJETIVO DESSE ARTIGO BUSCA APRESENTAR O RECORTE DE UM MODELO DE REFERÊNCIA DE QUALIDADE DE CURADORIA DE CONTEÚDO PARA A EAD DESTACANDO DUAS DE QUATRO DIMENSÕES IMPRESCINDÍVEIS PARA TAL APLICAÇÃO, A DIMENSÃO PEDAGÓGICA E A TECNOLÓGICA. A PESQUISA SE CONFIGURA COMO EMPÍRICA COM LEVANTAMENTO DE DADOS COM ENFOQUE QUANTITATIVO ATRAVÉS DE QUESTIONÁRIO E QUALITATIVO ATRAVÉS DE ENTREVISTAS. O PÚBLICO ALVO CONSULTADO FORAM PROFESSORES UNIVERSITÁRIOS,AVALIADORES DO MEC, IBLIOTECÁRIOS E GESTORES DE IES E DE EDTECHS. OS RESULTADOS APONTADOS A DUAS DIMENSÕES ABORDADAS COMO COMPLEMENTARES E A NECESSIDADE DE UM PROCESSO MAIS APROFUNDADO DE DESENVOLVIMENTO DE PROFESSORES CURADORES SOBRE AS CARACTERÍSTICAS DAS DIMENSÕES PARA UM PROCESSO DE CURADORIA MAIS QUALIFICADO E PRÓXIMO DA REALIDADE DO ALUNO,REFORÇANDO O CONHECIMENTO DO USO E CARACTERÍSTICAS DE RECURSOS QUE ENVOLVEM OBJETOS DE APRENDIZAGEM, INTELIGÊNCIA ARTIFICIAL E APRENDIZAGEM ADAPTATIVA POR MEIO DE METODOLOGIAS ATIVAS E DA HIBRIDIZAÇÃO DAS MODALIDADES DE ENSINO
POSSIBILIDADES FORMATIVAS E CRIATIVAS NO CONTEXTO DE PANDEMIA — CONHECIMENTOS EAPRENDIZAGENS PRODUZIDAS E MOBILIZADAS POR FUTUROS PROFESSORES EM UMA DISCIPLINA DE ESTÁGIO
Authors:   UNIVERSIDADE CIDADE DE SÃO PAULO, MARTINS PRISCILA BERNARDO , CARVALHO JANE GARCIA DE ,   UNIVERSIDADE CRUZEIRO DO SUL
Published: May 2022

NESSE ARTIGO BUSCAMOS EVIDENCIAR E DISCUTIR COMO A PROPOSTA DO PLANO DE ATIVIDADES EMERGENCIAIS IMPLEMENTADA EM UMA DISCIPLINA DE ESTÁGIO CURRICULAR SUPERVISIONADO EM MATEMÁTICA NOS ANOS FINAIS DO ENSINO FUNDAMENTAL, OFERTADA NO CURSO DE LICENCIATURA EM MATEMÁTICA NA MODALIDADE EAD DE UMA INSTITUIÇÃO DE ENSINO SUPERIOR PRIVADA NA CIDADE DE SÃO PAULO, PODE CONTRIBUIR PARA A PRODUÇÃO E MOBILIZAÇÃO DOS CONHECIMENTOS DAS APRENDIZAGENS DOS FUTUROS PROFESSORES. PARA ISSO, O ESTUDO FOI NORTEADO POR UMA ABORDAGEM DE CUNHO QUALITATIVO. DENTRE OS RESULTADOS PODEMOS DESTACAR QUE, COM AS ATIVIDADES EMERGENCIAIS PARA REALIZAÇÃO DE ESTÁGIO, FICOU CLARO QUE AS INSTITUIÇÕES DE ENSINO DEVEM PROMOVER FORMAÇÕES QUE INCORPOREM O DESENVOLVIMENTO DAS COMPETÊNCIAS, NOS FUTUROS PROFESSORES,POR MEIO DE REFLEXÃO DE UMA POSSÍVEL PRÁTICA PROFISSIONAL. OU SEJA, OS PROFESSORES PRECISAM SER SUBMETIDOS A SITUAÇÕES EM QUE VIVENCIEM AS COMPETÊNCIAS GERAIS E ESPECÍFICAS DE UM DOCUMENTO NORTEADOR QUE VISA ALINHAR DOCUMENTOS CURRICULARES BRASILEIROS, LEVANDO EM CONTA AS APRENDIZAGENS QUE OS ESTUDANTES DEVEM ALCANÇAR
TRANSVERSALIDADE E ENSINO ADAPTATIVO NA EDUCAÇÃO CONTINUADA DA POLÍCIA MILITAR DO ESTADO DE SÃO PAULO
Authors:   POLÍCIA MILITAR DO ESTADO DE SÃO PAULO, CORREA ENOS LUIZ DA SILVA , RIBEIRO EDUARDO AUGUSTO ALVES ,   POLÍCIA MILITAR DO ESTADO DE SÃO PAULO
Published: May 2022

ESTE ARTIGO RELATA A ESTRATÉGIA METODOLÓGICA PARA O PLANEJAMENTO E APLICAÇÃO DA TRANSVERSALIDADE E DO ENSINO ADAPTATIVO NA EDUCAÇÃO CONTINUADA DA POLÍCIA MILITAR DO ESTADO DE SÃO PAULO, A PARTIR DO PLANEJAMENTO CURRICULAR E DO USO DAS TECNOLOGIAS EDUCACIONAIS. A ABORDAGEM DESTE TEMA TEM COMO ESCOPO DEMONSTRAR OS PROCESSOS DE GESTÃO E A PRÁXIS DOCENTE PARA O FOMENTO DE APRENDIZAGENS MULTIDISCIPLINARES, QUE ABRANJAM OS CONHECIMENTOS NECESSÁRIOS AOS PROFISSIONAIS DE SEGURANÇA PÚBLICA, DE FORMA QUE POSSAM SER APLICADOS DE MANEIRA PLENA, CORRELACIONADOS ENTRE TODAS AS DISCIPLINAS NECESSÁRIAS À ATUALIZAÇÃO E APERFEIÇOAMENTO DOS POLICIAIS MILITARES, NOS MAIS DIFERENTES NÍVEIS. NÃO OBSTANTE, ESTA ESTRATÉGIA DE ENSINO E APRENDIZAGEM BUSCA CONTEMPLAR AS CARACTERÍSTICAS E NECESSIDADES PARTICULARES DOS DISCENTES, NA MEDIDA EM QUE CONSIDERA OS ESTILOS DE APRENDIZAGEM E AS INTELIGÊNCIAS MÚLTIPLAS, VALENDO-SE DAS HABILIDADES SINESTÉSICAS PAUTADAS NAS POTENCIALIDADES DE CADA ALUNO, A FIM DE QUE SE GARANTA, COMO RESULTADO, UMA APRENDIZAGEM SIGNIFICATIVA. NESTE SENTIDO, SERÃO APRESENTADAS AS PROPOSTAS DE CONSTRUÇÃO DOS CURRÍCULOS,FORMAÇÃO DOCENTE E AS ESTRATÉGIAS EDUCACIONAIS IMPLEMENTADAS NO SISTEMA DE ENSINO DA PMESP, PARTICULARMENTE AQUELAS SUPORTADAS PELAS NOVAS TECNOLOGIAS DA INFORMAÇÃO E COMUNICAÇÃO (NTIC)
METODOLOGIAS ATIVAS E GAMIFICAÇÃO NA EDUCAÇÃO A DISTÂNCIA: ANÁLISE DA PARTICIPAÇÃO NOS MOMENTOS SÍNCRONOS EM UM CURSO DE EXTENSÃO
Authors:   UNIVERSIDADE FEDERAL DE SANTA CATARINA, RAMOS DANIELA KARINE , ANASTÁCIO BRUNA SANTANA ,   UNIVERSIDADE FEDERAL DE SANTA CATARINA, SILVA GLEICE ASSUNÇÃO DA ,   INSTITUTO FEDERAL DE SANTA CATARINA, PIRES LEILA URIOSTE ROSSO ,   PONTIFÍCIA CATOLICA DE SÃO PAULO
Published: May 2022

ESTE TRABALHO TEM COMO OBJETIVO ANALISAR A PARTICIPAÇÃO DE CURSISTAS NOS ENCONTROS SÍNCRONOS DE UM CURSO DE EXTENSÃO EM METODOLOGIAS ATIVAS DE APRENDIZAGEM BASEADA EM JOGOS, PARA IDENTIFICAR ESTRATÉGIAS PEDAGÓGICAS QUE PODEM CONTRIBUIR PARA INCENTIVAR UMA POSTURA MAIS ATIVA. TRATA-SE DE UMA PESQUISA CARACTERIZADA COMO ESTUDO DE CASO COM FOCO EM UMA COMUNIDADE VIRTUAL (NÃO GEOGRÁFICA) DE FORMAÇÃO. A ABORDAGEM DO PROBLEMA CARACTERIZASE POR UMA METODOLOGIA QUALITATIVA, PERMITINDO UMA COMPREENSÃO MAIS DETALHADA E DESCRITIVA DOS PROCESSOS REALIZADOS E VIVENCIADOS NO CONTEXTO DE PESQUISA. A ANÁLISE PAUTOU-SE NOS VÍDEOS GRAVADOS E NOS REGISTROS DOS CHATS DOS ENCONTROS SÍNCRONOS REALIZADOS COMO PARTE DO CURSO DE FORMAÇÃO. OBSERVOU-SE O NÍVEL DE PARTICIPAÇÃO, COMO UM ASPECTO IMPORTANTE DAS METODOLOGIAS ATIVAS NA EDUCAÇÃO A DISTÂNCIA, CONSIDERANDO COMO INDICADOR A QUANTIDADE DE PALAVRAS POSTADAS NO CHAT DE INTERAÇÃO DE APOIO DO SISTEMA DE VIDEOCONFERÊNCIA DIVIDIDO PELA QUANTIDADE DE PARTICIPANTES. OS RESULTADOS REVELARAM QUE OS ENCONTROS SÍNCRONOS QUE UTILIZARAM METODOLOGIAS ATIVAS TIVERAM UM MAIOR ÍNDICE DE PARTICIPAÇÃO DOS CURSISTAS, DESTACANDO AS ESTRATÉGIAS PEDAGÓGICA PAUTADAS NA DINÂMICA DO JÚRI SIMULADO E NO USO DO KAHOOT
ESTUDO DE CASO:INOVAÇÃO DESRUPTIVA DA METODOLOGIA DE ENSINO BASEADO EM PROJETOS PARA MEIO DIGITAL COM GANHO ECONÔMICO
Authors:   FACULDADES DE EXTREMA, COBERO CLAUDIA , JUNIOR JUVÊNCIO JUNIOR BEZERRA LOIOLA ,   FACULDADES DE EXTREMA
Published: May 2022

O PRESENTE TRABALHO TRATA-SE DE UM ESTUDO DE CASO DE UMA IES QUE MEIO AO CENÁRIO DE PANDEMIA E COMO FORMA DE MANTER SUA QUALIDADE NO ENSINO E SE MANTER NO MERCADO, BUSCOU UMA NOVA METODOLOGIA DE ENSINO PARA O MEIO DIGITAL. BUSCOU-SE POR UMA EMPRESA PARCEIRA, COM UMA METODOLOGIA INOVADORA E COM UMA PLATAFORMA ESPECÍFICA PARA A APRENDIZAGEM BASEADA EM PROJETOS. COM A ADESÃO DE UMA NOVA METODOLOGIA E UMA NOVA PLATAFORMA, OS PROFESSORES DA IES PASSARAM POR DIVERSOS CAPACITAÇÕES E METODOLOGIA DE AULA E DE ENSINO FORAM TOTALMENTE INOVADAS. ESSA NOVA FERRAMENTA E METODOLOGIA APLICOU-SE A 1300 ALUNOS DE DIVERSOS CURSOS SUPERIORES BACHAREIS E TECNOLÓGICOS NO PERÍODO DE 1 ANO. NOTOU-SE QUE HOUVE GRANDE ADESÃO POR PARTE DOS ALUNOS E PROFESSORES DA IES E O NÚMERO DE ALUNOS REMATRICULADOS E INGRESSANTES NA IES NO INÍCIO DE 2021 FOI SUPERIOR AO PERÍODO LETIVO ANTERIOR A PANDEMIA. FOI POSSÍVEL COMPROVAR-SE ENTÃO QUE A MUDANÇA NA GESTÃO E NA METODOLOGIA CORROBORARAM PARA A SOBREVIVÊNCIA DA IES NESSE PERÍODO DE PANDEMIA E AGREGOU VALORES NA FORMAÇÃO DOS ALUNOS
VENDO COM OUTROS OLHOS: UMA CAPACITAÇÃO EAD EM AUDIODESCRIÇÃO DIDÁTICA
Authors:   UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO, FERNANDES EDICLEA MASCARENHAS
Published: May 2022

PROMOVER A ACESSIBILIDADE PARA ALUNOS COM DEFICIÊNCIA VISUAL AINDA É UM DESAFIO PARA AS INSTITUIÇÕES DE ENSINO. NESSE CENÁRIO, A CAPACITAÇÃO DOCENTE SE APRESENTA COMO UMA DAS AÇÕES NECESSÁRIAS E URGENTES PARA PROMOVER A INCLUSÃO DESSE PERFIL DE ALUNO. O PRESENTE ESTUDO TEM COMO OBJETIVO APRESENTAR UM RELATO DE EXPERIÊNCIA SOBRE O DESENVOLVIMENTO E A IMPLEMENTAÇÃO DE UMA CAPACITAÇÃO EAD EM AUDIODESCRIÇÃO DIDÁTICA PARA A EQUIPE DOCENTE DO CURSO DE LICENCIATURA EM GEOGRAFIA DO CONSÓRCIO CEDERJ. A CAPACITAÇÃO FOI DESENVOLVIDA AO LONGO DE UMA PESQUISA DE MESTRADO PROFISSIONAL EM DIVERSIDADE E INCLUSÃO. FOI PAUTADA NO ESTADO DA ARTE DA AUDIODESCRIÇÃO E APLICADA A 20 PARTICIPANTES, NA MODALIDADE DE ENSINO A DISTÂNCIA (EAD). PARA O CURSO FOI DESENVOLVIDO UM MATERIAL DIDÁTICO QUE ESTÁ DISPONÍVEL GRATUITAMENTE PARA DOWNLOAD NO BLOG VENDO COM OUTROS OLHOS,SOB A LICENÇA CREATIVE COMMONS DE ATRIBUIÇÃO-NÃO COMERCIAL 4.0 INTERNACIONAL
DIFICULDADES NAS AULAS REMOTAS DE ESTUDANTES COM SURDEZ EM RELAÇÃO A DISPONIBILIZAÇÃO DE LEGENDAS EM OBRAS AUDIOVISUAIS
Authors:   UNIVERSIDADE DE BRASÍLIA, FILHO ELIAS DO NASCIMENTO MELO , BEATRIZ CAMPOS BEATRIZ CAMPOS ,   INSTITUTO DE EDUCAÇÃO SUPERIOR DE BRASÍLIA
Published: May 2022

ESTE ARTIGO TEM O OBJETIVO DE CONTEXTUALIZAR AS DIFICULDADES DOS ESTUDANTES COM SURDEZ, NAS AULAS REMOTAS, QUE CARECEM DE OBRAS AUDIOVISUAIS QUE POSSUAM LEGENDAS, PARA QUE ESTE PÚBLICO POSSA APRECIAR E ENTENDER ESSAS OBRAS. ESSA É UMA DIFICULDADE MUITO COMUM DA EDUCAÇÃO A DISTÂNCIA, E ESSA DISPONIBILIDADE DE LEGENDAS É UM PONTO MUITO IMPORTANTE PARA AS PESSOAS COM SURDEZ, O QUE FAVORECE AINDA MAIS A APRENDIZAGEM NAS AULAS A DISTÂNCIA. ALÉM DISSO, ESSE ARTIGO CONCEITUA SOBRE O CONTEXTO DE COMO AS LEGENDAS DEVEM SER APLICADAS NAS OBRAS AUDIOVISUAIS. ESTE ARTIGO FOI REALIZADO POR MEIO DA METODOLOGIA DE ENTREVISTA NÃO ESTRUTURADA COM A OPINIÃO DE 3 ESTUDANTES DO CURSO DE GRADUAÇÃO EM CINEMA, SOBRE O USO DE LEGENDAS EM OBRAS AUDIOVISUAIS APRESENTADAS EM SALA DE AULA REMOTA. COMO RESULTADO, O ARTIGO APRESENTA UMA DIVERSIFICAÇÃO DE OPINIÕES QUE SÃO RESUMIDOS PELA FALTA NOTÓRIA DE LEGENDAS NAS OBRAS AUDIOVISUAIS, PRINCIPALMENTE LANÇADAS NO BRASIL, E UMA DIFICULDADE APARENTE DOS PROFESSORES EM TRABALHAR DE MELHOR FORMA COM ESSE TIPO DE MATERIAL.
PRÁTICAS PEDAGÓGICAS E CRIATIVIDADE NA EDUCAÇÃO BÁSICA: O JOGO MINECRAFT E SUAS POTENCIALIDADES EDUCATIVAS
Authors:   ENSINO MÉDIO COM INTERMEDIAÇÃO TECNOLÓGICA/IFBA, FERREIRA GRAÇA REGINA ARMOND MATIAS , MATIAS LORENA DE ANDRADE ,   COLÉGIO BOM PASTOR
Published: May 2022

O OBJETIVO DESTE TRABALHO É APRESENTAR AS POTENCIALIDADES PEDAGÓGICAS O USO DO JOGO MINECRAFT NA EDUCAÇÃO INFANTIL E FUNDAMENTAL. O JOGO COMO PRÁTICA EDUCATIVA OFERECE POTENCIALIDADES PEDAGÓGICAS QUE PERMITEM QUE OS ESTUDANTES POSSAM IMERGIR NO UNIVERSO CRIATIVO E, A PARTIR DESSAS EXPERIÊNCIAS POSSIBILITAR O APRENDIZADO ATRAVÉS DE CONTEÚDOS CURRICULARES.TRATA-SE DE UMA PESQUISA NARRATIVA, TENDO A OBSERVAÇÃO E IMERSÃO NO JOGO IDENTIFICANDO ALGUMAS POSSIBILIDADES APONTADAS PELAS CRIANÇAS NESSA VIVÊNCIA FORMATIVA A PARTIR DA IDENTIFICAÇÃO DE CATEGORIAS ANALISADAS PELAS NARRATIVAS PRODUZIDAS. OS RESULTADOS INDICAM UMA POTÊNCIA NO USO DOS JOGOS, NO CASO O MINECRAFT, NESTE PÚBLICO E QUE É POSSÍVEL APROVEITAR ESSA EXPERIÊNCIA PARA ATRELAR ESTE RECURSO AO CURRÍCULO ESSENCIAL COMO UMA ALTERNATIVA DE INCREMENTO PEDAGÓGICO QUE PRECISA SER MAIS APROVEITADA COM INVENTIVIDADE, O QUE TRAZ UM CONTRAPONTO AO INSTRUCIONISMO DANDO LUGAR A PRÁTICAS CRIATIVAS INOVADORAS.
O DESENVOLVIMENTO DO GAME LUKA: UM JOGO DIGITAL PARA APOIAR O DESENVOLVIMENTO DE HABILIDADES ARGUMENTATIVAS
Authors:   UNIVERSIDADE FEDERAL DE PERNAMBUCO, MIRANDA FELLIPE GIOVANNE NERI , CASTRO LAIS ARAÚJO ,   UNIVERSIDADE FEDERAL DE PERNAMBUCO, SILVEIRA RAPHAEL HONÓRIO FERRO DA ,   COLÉGIO SANTA BÁRBARA, PEREIRA LEONARDO EMANUEL CARVALHO GONÇALVES ,   C6 BANK, SANTOS JOÃO VICTOR DE SANTANA ,   UNIVERSIDADE FEDERAL DE PERNAMBUCO, MELO NATHÁLIA PATRÍCIA TEÓFILO BEZERRA DE ,   UNIVERSIDADE FEDERAL DE PERNAMBUCO, VALENÇA ALISSON MICHEL SILVA ,   UNIVERSIDADE FEDERAL DE PERNAMBUCO
Published: May 2022

A BASE NACIONAL COMUM CURRICULAR DESTACA A ARGUMENTAÇÃO COMO UMA DAS COMPETÊNCIAS ESSENCIAIS A SEREM DESENVOLVIDAS NA EDUCAÇÃO BÁSICA BRASILEIRA. COM BASE EM UMA REVISÃO BIBLIOGRÁFICA NA ÁREA DE ARGUMENTAÇÃO, FOI DESENVOLVIDO O JOGO LUKA, UM GAME QUE TEM O OBJETIVO DE APOIAR O DESENVOLVIMENTO DE HABILIDADES ARGUMENTATIVAS. A NARRATIVA DO JOGO CONTA A HISTÓRIA DO JOVEM LUKA QUE RECEBE A MISSÃO DE VIAJAR AO LONGO DO TEMPO PARA AJUDAR PESSOAS, ATRAVÉS DA ARGUMENTAÇÃO E, COM ISSO, IMPEDIR UM FUTURO APOCALÍPTICO PARA O MUNDO. OS PRESSUPOSTOS TEÓRICOS DO JOGO, O PROCESSO DE CONSTRUÇÃO DO JOGO, BEM COMO SUAS MECÂNICAS E NARRATIVAS SERÃO DETALHADAS NO PRESENTE TRABALHO. O JOGO FOI DESENVOLVIDO POR UM PESQUISADOR DE DOUTORADO EM PSICOLOGIA COGNITIVA, QUATRO ESTUDANTES DE GRADUAÇÃO EM PSICOLOGIA, UM PROFESSOR-CONSULTOR DE GEOGRAFIA E UM GAME DESIGNER/DEVELOPER E FOI TESTADO POR 259 PROFESSORES E PROFESSORAS DO BRASIL E SUAS RESPECTIVAS TURMAS.
Quantification of SARS-CoV-2 variant mutations (HV69-70, E484K/N501Y,del156-157/R158G, del143-145, and LPPA24S) in settled solids using digital RT-PCR v2
Authors: Hughes Bridgette , J. White Bradley , K. Wolfe Marlene , B B Boehm Alexandria
Published: May 2022

This process instruction describes the steps for quantitative analysis of nucleic acid from SARS-CoV-2 with a triplex Reverse Transcriptase droplet digital Polymerase Chain Reaction (RT-ddPCR) assay targeting the N Gene, S Gene and 3 mutation assays (one each for HV69-70, E484K/N501Y, del156-157/R158G, del143-145, and LPPA24S) in extracted and purified RNA samples from solid wastewater samples for population level SARS-CoV-2 community surveillance. RT-ddPCR is a modified version of conventional RT-PCR workflows which involves separating the reaction mixture into many partitions (~20,000) before thermal cycling which allows for direct absolute quantification of the target RNA molecules. Future protocols will be published that are complementary to this one and describe assays targeting additional SARS-CoV-2 mutations. This protocol uses RNA extracted using this protocol: High Throughput RNA Extraction and PCR Inhibitor Removal of Settled Solids for Wastewater Surveillance of SARS-CoV-2 RNA. That RNA is generated from samples subjected to pre-analytical steps outlined in: High Throughput pre-analytical processing of wastewater settled solids for SARS-CoV-2 RNA analyses. It is recommended that these assays be run along assays for PMMoV and BCoV as controls as described in the companion protocol High Throughput SARS-COV-2, PMMOV, and BCoV quantification in settled solids using digital RT-PCR The readout of this assay is a concentration of each target in the extracted RNA samples (copies/µL). Scope This process instruction applies to quantitative analysis of nucleic acid from SARS-CoV-2 RNA from solid wastewater samples with ddPCR using a Bio-Rad AutoDG Droplet Digital PCR system consisting of the AutoDG Automated Droplet Generator and the QX200 droplet reader.
High Throughput SARS-COV-2, PMMOV, and BCoV quantification in settled solids using digital RT-PCR v5
Authors: Topol (Verily Life Sciences) Aaron , not provided marlene.wolfe , Wigginton Krista , B Boehm Alexandria
Published: May 2022

v3 updates: changes to the S gene primers and probes for detection of all SARS-CoV-2 variants This process instruction describes the steps for quantitative analysis of nucleic acid from SARS-CoV-2 with a triplex Reverse Transcriptase droplet digital Polymerase Chain Reaction (RT-ddPCR) assay targeting the N Gene, S Gene and ORF1a and a duplex assay targeting Bovine Coronavirus Vaccine (BCoV) and Pepper Mild mottle virus (PMMoV) in extracted and purified RNA samples from solid wastewater samples for population level SARS-CoV-2 community surveillance. RT-ddPCR is a modified version of conventional RT-PCR workflows which involves separating the reaction mixture into many partitions (~20,000) before thermal cycling which allows for direct absolute quantification of the target RNA molecules. This protocol uses RNA extracted using this protocol: High Throughput RNA Extraction and PCR Inhibitor Removal of Settled Solids for Wastewater Surveillance of SARS-CoV-2 RNA. That RNA is generated from samples subjected to pre-analytical steps outlined in: High Throughput pre-analytical processing of wastewater settled solids for SARS-CoV-2 RNA analyses. This protocol describes 2 separate PCR reactions, one containing primer/probe mixtures targeting the three SARS-CoV-2 targets and one containing primer/probe mixtures targeting BCoV and PMMoV. BCoV is spiked into samples before nucleic acid extraction and serves as a process control as well as an indicator of PCR inhibition. PMMoV is an enveloped virus which is abundant in human fecal waste and serves as an endogenous control for data normalization. PMMoV RNA is abundant at such high levels in wastewater samples that the samples must be diluted by a factor of 100 before quantification. The readout of this assay is a concentration of each target in the extracted RNA samples (copies/uL). Scope This process instruction applies to quantitative analysis of nucleic acid from SARS-CoV-2 RNA from solid wastewater samples with ddPCR using a Bio-Rad AutoDG Droplet Digital PCR system consisting of the AutoDG Automated Droplet Generator and the QX200 droplet reader.
N-Words in Dawurotsuwa
Authors: Naba Aklilu Abera
Published: May 2022

This article investigates n-words in Dawurotsuwa, which is classified under the Omotic language family under the Afroasiatic phylum. Speakers of the language are found in Ethiopia, specifically in the southwest part of the country. The study aims to describe n-words in this language, which is one of the scarcely described languages in the area. N-words in the language are formed by suffixing the morpheme -kka/-nne to content question words. These morphemes also mark indefiniteness in the language. These formed n-words express negation in fragmented answers but don’t in a complete main clause. In the main clause, they are accompanied by sentential negative markers to transfer negative meanings. In Dawurotsuwa, n-words are not inherently negative. These n-word-forming morphemes -nne and -kka are also used for coordinating conjunction and emphatic coordination, respectively. The morpheme -kka also serves as a scalar focus suffix. They also express a specificity that is indefinite, but when the specificity is definite, the last vowel changes to -o and becomes only -kko. Thus, n-words can be named indefinite pronouns.
Letting the Struggling Saudi EFL Readers Take Lead: How Teachers Transform English Language Instruction
Authors: Sharma Vipin
Published: May 2022

The paper intends to divulge and argue the major reading problems Saudi students face and flaws in contemporary research that affects a lot on developing their reading skills. The problems and pitfalls related to reading skill, prime facie, seem traditional but widely discussed; hitherto, remain unsettled in the arena of language learning. The researcher tries to explore and shed light on these problems while achieving different asymptotic levels of performance, constrained and unconstrained skills to observe and experience how far and fast the Saudi EFL learners master the reading skills in and out of classroom settings at Jazan University. It is solely based on experience and observational data that the researcher has collected on his students’ everyday classroom performance. The paper also monitors how far the previous findings contributed to overcome struggling readers’ problems and improve their reading abilities and suggests how recognizing these major occurring problems may endow with an authentic and viable initiative for planning reading instruction and interventions. Hence, the present study aims to provide in-depth examination and interpretation of struggling Saudi EFL learners’ problems and challenges meting out different texts in structure and related aspects on different reading tasks. The paper concludes with some vital suggestions that would indubitably help learners and teachers practice in realia to lessen anxiety, achieve desired outcomes and evolve educational policies for language instruction, evaluation and assessment.
A Correlative Study on English Listening Beliefs and Strategies of Chinese High School Students—A Case in Fujian Province
Authors: Wu Yajing , Peng Mei
Published: May 2022

This study investigates the correlation between language learning beliefs and strategies in terms of listening comprehension. Data were collected from 94 tenth graders in a Chinese high school in Fujian Province through questionnaires and in-depth interviews. The findings show a significant and positive correlation between English listening beliefs and strategies, which influence each other to varying degrees. Specifically, the participants were reported to hold various beliefs on English listening while employing a range of strategies for listening comprehension, though the frequency of their overall strategy use was at the medium level. Furthermore, cognitive strategies were found to be the most frequently used ones, followed by socio-affective strategies and metacognitive strategies. Based on the research findings, this article suggests that high school English teachers should help learners foster positive beliefs which normally lead to effective use of learning strategies; meanwhile, learners are advised to keep aware of what beliefs they hold, what strategies they use most or least, and what alternative strategies they can select so as to enhance their metacognition level and improve their listening comprehension.
Disorders of high psychic functions in patients in the early recovery period of the ischemic insult
Authors: Gusev E. I. , Burd G. S. , Gekht A. B. , Bogolepova A. N.
Published: May 2022

The state, of high psychic functions depending on the ischemic focus localization and disease gravity in the early recovery period of the ischemic insult is studied in 51 patients with left and right hemisphere insult. The neuropsychologic examination is performed using A. P. Luriyas method with tests for assessment of all kinds of praxis, gnosis, memory, speech, intellectual processes. The additional assessment of the functional state of various cerebral zones is given. The disorders of praxis (dynamic, postural, spatial), of visual-constructive activity, aural and speech memory, count, visual and acoustic gnosis prevail in the early recovery period. This suggests the disfunction of posterofrontal, temporal and parietal structures vascularized principally by the region of the middle cerebral artery.
Ability to adaptation — an integrative criterion in neuropsychorehabilitation system
Authors: Shmidt I. R. , Kogan O. G.
Published: May 2022

The use of ability to adaptation index in neurology clinic proved to be adequate in the decision of basic tasks occuring in the process of treatment, rehabiltiation and prophylaxis of neurologic diseases. The characteristic of individual peculiarities of the disease, epidemiologic characteristic of the selection, treatment efficacy estimation, rehabilitation level, prognosis tasks, medicoworking examination, distribution by dispensary account groups and prophylactic measures efficacy estimation are among these tasks.
Psychorehabilitation aspects in vascular diseases of the brain
Authors: Skoromets A. A. , Burakova Z. F. , Skoromets T. A.
Published: May 2022

The psychorehabilitation measures are performed in patients with vascular pathology of the brain. The possibility to form the active aim at psychohygienic neurovascular self-regulation, to use the autorelaxation habits in psychotraumatizing situations in patients is shown, resulting in an increase of the efficacy of rehabilitation measures and prolongation of the ability to work of the contingent.
Possibilities of the functional rehabilitation of dysgemic disorders of adaptation in patients with initial stages of cerebrovascular diseases
Authors: Shutov A. A. , Shestakov V. V.
Published: May 2022

The cerebral blood flow, adaptive functions of supsegmental vegetative formations, neuropsychologic status, encephalography are studied in 121 patients with initial stages of cerebrovascular diseases. The relationshipbetween indices and the degree of the progress of vascular pathology is revealed. The rehabilitation complex is proposed which is promising for the treatment and recovery of cerebral blood flow in patients with initial stages of cerebrovascular diseases.
Endovascular lasertherapy in combined rehabilitation of patients with cerebral insult
Authors: Livshits L. Y. , Ageeva T. S. , Rassomakhin A. A.
Published: May 2022

The treatment of 36 patients with ischemic insult is performed using endovescular laser irradiation of blood. This therapy has an essential effect on the clinical state of patients, is beneficial for the recovery of motor functions, suppresses the processes of peroxide oxidation of lipids, removes an excess of cholesterol from erythrocyte membranes, providing the basis of positive changes of microhemocirculation and correspondingly blood supply of cerebral tissue. The method is suggested for treatment of patients with cerebrovascular pathology.
New possibilities of rehabilitation of the disordered motor and speech functions in patients with paralyses of the cerebral origin
Authors: Barer A. S. , Semeneva K. A. , Dotsenko V. I. , Sinigin V. M. , Sologtlbov E. G. , Tikhomirov E. P. , Sheinkman O. G.
Published: May 2022

The theoretical justification of the new rehabilitation method of the disordered motor and speech functions of patients with paralyses of the cerebral origin is given. The method provided is based on the formation (recovery) of new functional connections at the expense of the afferentation from periphery and improvement of tissue trophicity being under load.
Individual program of physical rehabilitation of patients with infantile cerebral paralysis late in residual period of the disease
Authors: Isanova V. A.
Published: May 2022

In conditions of the specialized rehabilitation center the combined treatment including the Petos conductive pedagogy method provides the satisfactory result in diplegic and spasticorigid forms and comparatively weak effect of the treatment in hyperkinetic form.
Correction of motor disorders in some psychic diseases in the early age
Authors: Goryunova A. V.
Published: May 2022

In children with schizophrenia the motor disorders are studied and their connection with psychic disfunctions in infancy is defined. As many as 112 children I the early age are examined: one-sided burdening - is revealed in 80 of these, doublesided burdening in 32 of these. The peculiarities of postural motor development and Various motor disfunctions are noted, which can be correlated with psychic endogenic disease in infancy or schizo- typical diathesis as a manifestation of sctizophrenic development and can be diagnosed in the first year of life. The early correction of motor development disorders directed to the normalization and stimulation of motility with an accent on the training of normal poses and motions, provides the maturation of not only motor but also psychic functions, stimulates the development of high integrative centers having an inhibiting effect on the truncal mechanisms activity.
Rehabilitation treatment of patients after ischemic spinal insult of lumbosarcral Localization
Authors: German D. G. , Pascal O. K.
Published: May 2022

The results of rehabilitation treatment of patients after ischemic spinal insult of lumbosacral localization using sermion and terrilitine electrophoresis with subsequent ultrasound effect on the region of affected segments of the spinal cord are presented. The positive effect of sermion electrophoresis with subsequent ultrasound effect is revealed in the basic groupin 80% of the patients and in the treatment with terrilitine in 75%. The results given allow to recommend the methods proposed for the wide introduction in practice.
Clinico-physiologic characteristic of patients with birth paralyses of the upper extremities
Authors: Kurénkov A. L. , Dotsenko V. I. , Sholomov I. I. , Vagner I.
Published: May 2022

Based on the results of clinical, electromyographic and electroneurographic examinations of 42 children with birth paralyses of the upper extremities, the conclusion regarding the injury in birth of essentially peripheric nerves with relative intactness of the spinal cord is made. The clinicoelectromyographic picture corresponds the spinal level of the injury only in 4,8% of the cases, and the combined nature of the injury may be assumed in 7,1% of the patients.
Experience in the use of computed tomography in the diagnosis of brain diseases
Authors: Mikhailov M. K. , Akberov R. F. , Appakova A. Z. , Ziyatdinov K. S.
Published: May 2022

From 1989 to 1992, X-ray computed tomography (CT) of the skull and brain was performed in 183 patients on the basis of the Medical Unit "Radiopribor" in Kazan. There were 71 children (30 boys, 41 girls), adult patients aged 20 to 69 years - 112 (45 men, 67 women).
Morphofunctional features of the soleus muscle
Authors: Kadyrova L. A. , Tereshchenko A. A. , Marchenko V. G.
Published: May 2022

In the clinical manifestations of ischiocrural syndromes, a significant role belongs to the triceps muscle of the lower leg, especially the soleus. What morphological and functional features of the soleus muscle can be displayed in the clinic of ischiocrural syndromes? In order to identify these features, we undertook a macromicroscopic study of 57 anatomical preparations.
New aspects of the pathogenesis of gunshot wounds
Authors: Shaposhnikov Yu. G. , Kesyan G. A. , Kondratieva I. E. , Zasukhina G. D. , Alekhina N. I.
Published: May 2022

Central Institute of Traumatology and Orthopedics. N.N. Priorova, Institute of General Genetics, MoscowAs a result of studies using the cytogenetic method, it was shown that gunshot injuries can cause violations of the integrity of the chromosomal apparatus, which persist for a long time and aggravate the severity of the wound process
Patella resection and patellectomy for comminuted fractures
Authors: Kuzmenko V. V. , Girshin S. G. , Litvina E. A.
Published: May 2022

The work is based on the analysis of the results of surgical treatment of 106 patients with multiple fractures of the patella, of which 92 underwent patella resection and 14 - patelllectomy. The indications for these operations are substantiated, the details of the surgical technique are described. To eliminate tension on the tendon-bone contact line (for resection) and tendon-tendon (for patelllectomy), a locking wire loop was used. Original methods have been developed for replacing extensor defects after resection of the lower third of the patella with autografts from the rectus muscle tendon and from the patellar ligament. Long-term results studied in 76 patients confirm the advantages of the proposed patellar resection and patelllectomy techniques
Indications for transosseous osteosynthesis and the limits of its use for fractures of long bones in children
Authors: Merkulov V. H. , Dorokhin A. I. , Stuzhina V. T. , Sokolov O. G. , Arkhipova I. M.
Published: May 2022

The results of treatment of 3067 children with long bone fractures were analyzed. The method of transosseous osteosynthesis was used in 114 children (116 fractures). The frequency of its use was, depending on the type and location of the fracture, from 0.9 to 21%. On the basis of a comprehensive study involving radiography, scintigraphy, polarography, echoosteometry, thermography, indications for the use of compression-distraction osteosynthesis in children have been developed and substantiated: the method is indicated for fractures of long bones with a complicated course - improperly fused fractures with unacceptable displacements, fractures with circulatory disorders and bone formation in the damaged area, multiple and difficult to reposition fractures. The choice of the type of apparatus was carried out individually
Evaluation of the elemental composition of bone tissue in children with genetically determined forms of rickets during treatment
Authors: Berezhny A. P. , Snetkov A. I. , Zaichik V. E.
Published: May 2022

Using neutron activation analysis, we determined the absolute values ​​and ratios of the concentrations of calcium, phosphorus, magnesium, sodium, potassium and chlorine in biopsies of the iliac wing in 20 children with genetically determined forms of rickets (GOFR) before and after drug treatment, as well as in 13 conditionally healthy children (control group). It has been shown that in children with GOFR, the content of calcium, phosphorus, sodium and more than 45% content of magnesium is statistically significantly reduced in comparison with the age norm by an average of 25-30%. Also revealed shifts in the ratio of the concentrations of Ca: Mg, Ca: Na and P: Na. Drug treatment in most children with GOFR leads to the normalization of all studied characteristics, with the exception of magnesium, the deficiency of which is manifested both in the absolute value of its content and in the ratio of Ca: Mg concentrations, which may indicate the need to include medicinal preparations containing magnesium
Asthma and COVID-19 in the elderly: course, survival, predictors of mortality
Authors: Gaynitdinova V. V. , Avdeev N. N. , Pozdniakova A. A. , Vlasenko A. Ye. , Baytimerova I. V. , Gneusheva T. V.
Published: May 2022

Bronchial asthma occurs in 0.9 – 17% of patients hospitalized with COVID-19. However, it is not clear whether asthma is a risk factor for the development and severity of COVID-19. Studies have shown that patients with asthma appear to be more susceptible to COVID-19 infection, but severe disease progression is not related to medication use, including asthma biologics, but rather to older age and comorbidities.

Aim.To evaluate the clinical course of SARS-CoV-2 infection in elderly patients with asthma, to examine the effect of asthma and comorbidities on COVID-19related outcomes, and to determine predictors of mortality.

Methods.Elderly patients [WHO, 2020] (> 60 years,n= 131, median age 74 (67; 80) years; 59 men, 72 women) with asthma hospitalized for COVID-19 were included in the study. COVID-19 was confirmed by laboratory tests (PCR smear) and/or clinical and radiological examinations. All patients had a history of a documented diagnosis of asthma (GINA, 2020).

Results.Out of 131 patients, 30 (22.9%) died in the hospital, and 15 (14.9%) died after discharge from the hospital (within 90 days). The group of patients with lethal outcome showed the following differences from those who recovered: values of Charlson index, respiration rate, degree of lung damage on CT scan, absolute number of leukocytes, neutrophils and neutrophils-to-lymphocytes ratio, C-reactive protein on the 5th day of hospitalization, and LDH were statistically significantly higher, while absolute number of eosinophils, total protein content, SpO2and SpO2/FiO2levels were lower; steroid intake during the year and non-atopic asthma were more common. Multivariate and ROC analysis revealed the most significant predictors of hospital mortality and their thresholds: Charlson comorbidity index ≥ 6 points, neutrophil/lymphocyte ratio ≥ 4.5, total protein ≤ 60 g/l, eosinophil level ≤ 100 cells/μL.

Conclusion.The most significant predictors of hospital mortality in elderly patients with severe COVID-19 against asthma are Charlson comorbidity, neutrophil/lymphocyte ratio; lower eosinophil and total protein levels. Survival time of patients has an inverse correlation with the number of mortality risk factors present.
Lipopolysaccharide-binding protein and presepsin in patients with SARS-CoV-2 viral lung disease in the Republic of Crimea
Authors: Yatskov I. A. , Beloglazov V. A. , Kubyshkin A. V. , Nikolaeva A. P. , Zyablitskaya E. Yu. , Kunitskaya Ju. E. , Lavrenchu E. N.
Published: May 2022

Although more than 2 years have passed since the beginning of the pandemic of the new coronavirus infection, treatment and prediction of the course of SARS-CoV-2 infection remain pressing global problems. In this regard, the search for additional links in the pathogenesis of SARS-CoV-2 is currently one of the most important tasks. The

Aim. To assess the level of lipopolysaccharide-binding protein (LBP) and presepsin (sCD14-ST) in patients with SARS-CoV-2 viral lung disease in Crimea.

Methods. We examined 121 patients with a positive PCR result for SARS-CoV-2 in the age group of 45 – 75 years who were hospitalized in the Department of Infectious Diseases, State Budgetary Healthcare Institution of the Republic of Crimea “N.A.Semashko Republican Clinical Hospital”. Patients were divided into 3 clinical groups according to the severity of SARS-CoV-2 infection: Group 1 – patients with moderate disease, Group 2 – patients with severe disease, and Group 3 – patients with fatal outcome. Peripheral blood levels of LBP, presepsin, ferritin, and C-reactive protein were determined upon admission to the infectious disease hospital.

Results. A significant increase in all studied parameters was observed in the 1st, 2nd and 3rd clinical groups of patients with coronavirus infection. This finding corresponds to the state of lipopolysaccharide-binding systems and systemic infection in patients with SARS-CoV-2 viral lung disease. The highest levels of LBP, sCD14-ST, and ferritin were registered in the 3rd clinical group. We found a direct correlation between LBP and sCD14-ST levels in the 2nd group (r = 0.523, p < 0.05) and the 3rd group (r = 0.748, p < 0.05).

Conclusion. Patients with SARS-CoV-2 lung disease were found to have an increased blood levels of LBP and presepsin upon admission. The highest values were observed in patients with fatal outcome. Severe SARSCoV-2 lung damage was associated with a direct correlation between levels of LBP and sCD14-ST. Presepsin, LBP, and ferritin are important prognostic markers for severe SARS-CoV-2 lung damage and risk of death in the early stages of hospital treatment.
Virus-induced and bacteria-induced exacerbations of chronic obstructive pulmonary disease caused by industrial aerosols or tobacco smoke exposure
Authors: Shpagina L. A. , Kotova O. S. , Shpagin I. S. , Kuznetsova G. V. , Gerasimenko D. A. , Anikina E. V.
Published: May 2022

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are associated with disease progression and increased risk of death. We need to better understand the phenotypes of AECOPD to improve treatment strategies. The main triggers of COPD exacerbations are viral and bacterial infections.

The aim is to characterize the viral, bacterial, and viral-bacterial phenotypes of acute exacerbations in patients with COPD caused by industrial aerosol exposure or tobacco smoke.

Methods. 180 subjects with established moderate and severe COPD who met the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, 2020 – 2021, and were hospitalized with AECOPD, were enrolled in this prospective observational study. The virus-induced, bacteria-induced, and virus-bacteria-induced AECOPD strata (n = 60 each) were formed. Each stratum included 30 patients with occupational COPD and 30 patients with COPD caused by tobacco smoke. Virus-induced AECOPDs were diagnosed by PCR of bronchoalveolar fluid. Length of hospital stay, symptoms, lung function, mean pulmonary artery pressure (mPAP), and type of inflammation were assessed. Cox proportional hazard regression was used to examine the relationships.

Results. The length of hospital stay was highest in patients with virus-induced and virus-bacteria-induced exacerbations of occupational COPD, being equal to (Me, IQR) 16.5 (14 – 18) and 18 (16 – 20) days. The virus-induced exacerbations in occupational COPD and in COPD caused by tobacco smoke featured the highest bronchodilation coefficient, 10.9 (9.8 – 11,5)% and 9.2 (8.3 – 10.3)%, respectively, decrease in the diffusing capacity of the lungs (DLCO/Va) by 42 (40 – 45)% and 49 (47 – 52)%, increase in mPAP by 44 (39 – 45) и 33 (29 – 38) mmHg, and eosinophilic inflammation with blood eosinophil count of 425 (385 –527) and 350 (310 – 391) cells per μl (р > 0.01). Virus-bacteria-induced AECOPD in occupational COPD and in COPD caused by smoke were characterized by decrease in FEV1 by 40.2 (36.6 – 42.2)% and 31.0 (28.1 – 33.6%), decrease in DLCO/Va by 48 (44 – 50)% and 37 (35 – 41)%, increase in mPA by 43 (38 – 46) and 50 (45 – 54) mmHg, and eosinophilic-neutrophilic inflammation in 63.3 and 66.6% of patients. The mid-range FEV1, highest DLCO/Va, and neutrophilic inflammation were seen in patients with bacteria-induced AECOPD.

Conclusion. Exacerbations of occupational COPD are characterized by more severe functional impairment and inflammation with high eosinophil count when these exacerbations have viral origin.
Chronic fibrosing interstitial lung diseases according to the register of Irkutsk (Russia)
Authors: Nashatyreva M. S. , Trofimenko I. N. , Chernyak B. A.
Published: May 2022

The Interstitial lung diseases (ILD) are a wide heterogeneous group of disorders, different in many parameters, however having similar pathophysiological mechanisms. Idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), chronic hypersensitivity pneumonitis (CHP), ILD associated with autoimmune disorders (predominantly systemic sclerosis (SSc ILD) and rheumatoid arthritis (RA ILD), and other diseases may be accompanied by the formation of pulmonary fibrosis. Currently there are no generally accepted criteria for the fibrosing and progressive fibrosing ILD, and the information on the frequency of these conditions is limited.

The study aims to research the structure of fibrosing ILD and the frequency of the progressive fibrosing phenotype (PFP) according to the register of patients with ILD in Irkutsk, Russia.

Methods. At the first stage information letters were sent to all medical institutions of Irkutsk with recommendations on all referral patients with ILD for further examination. At the second stage, each ILD case was verified collegially (n = 270). All patients’ data were analysed in terms of clinical, functional, radiological and histological aspects. A register of ILD patients was formed based on this analysis. The follow-up period was 1 to 5 years.

Results. According to the results of a comprehensive assessment, HRCT signs of pulmonary fibrosis were detected by 104 patients (38.5%). fibrosing course was observed in 100% IPF and SSc ILD, in 90.9% of CHP, 71.4% of NSIP and 60% of RA ILD. 61 patients (22.6% of all ILD cases, 58.6% of fibrosing ILD) was diagnosed with PFP. The 5-year mortality for PFP ILD was 55.5%.

Conclusion. In the case of a PFP development, the evolution of ILD loses its nosological specificity, acquiring similarity with IPF. Due to the high mortality rate, it is necessary to actively identify the progressive fibrosing course of a wide range of ILD and to prescribe an antifibrotic therapy in a timely manner.