bluuebunny/crossref_metadata_2025 huggingface dataset:
Butler e a Psicanálise: Do Fracasso das Normas à Estranheza do Gozo
Authors: Lima Vinícius Moreira , Bedê Heloísa Moura , Rocha Guilherme Massara
Published: March 2023

Resumo O objetivo deste artigo é fazer avançar o debate entre a psicanálise e os estudos queer, em especial a partir da interlocução traçada por Judith Butler com os trabalhos de Freud e Lacan. Retomando o modo como Butler articula Foucault, Derrida e a psicanálise para pensar os problemas de gênero, evidenciamos que a teoria psicanalítica permite à filósofa situar, a partir de sua concepção da melancolia de gênero, os pontos de fracasso da norma em função da vida psíquica do poder. Ainda que a cisheterossexualidade normativa imponha um roteiro de identificações e escolhas de objeto a seus sujeitos, há uma imprevisibilidade na maneira pela qual cada um responderá às injunções normativas da cultura, o que aponta para uma falha das normas em determinar completamente a subjetividade. A melancolia de gênero se torna, assim, uma marca da importância da psicanálise no percurso de Butler. Em seguida, discutimos as interpelações da filósofa ao simbólico lacaniano, bem como as nuances progressivamente introduzidas em sua leitura da diferença sexual. Ao longo do percurso de Butler, a diferença sexual deixa de ser considerada uma teoria da heterossexualidade e passa a ser apresentada como um conceito-borda, uma fronteira vacilante, que tomamos aqui como um convite para produzirmos uma releitura não normativa da diferença sexual na psicanálise a partir da teoria lacaniana da sexuação. Finalmente, localizamos a estranheza do gozo e o caráter irredutível da sexualidade às normas sociais como um importante eixo partilhado entre Butler e a psicanálise.
2.14.1 DRAG REDUCTION: INTRODUCTION
Authors: Hewitt Geoffrey F. , Bismarck A. , Griffen J. M. , Chen L. , Vassilicos John Christos
Published: March 2023

Insert the new sections in the folder for Part 2 after Section 2.13.
5.1.3 PROPERTIES OF PURE FLUIDS: VAPOUR PRESSURE, ENTHALPIES OF VAPORISATION AND BOILING AND MELTING POINTS OF PURE FLUIDS
Authors: Fenghour A.
Published: March 2023

Remove the existing Section 5.1.3 from the folder for Part 5 and insert new Section.
Transcriptional and Clonal Characterization of Cytotoxic T Cells in Crescentic Glomerulonephritis
Authors: Mueller Anne , Zhao Yu , Cicek Hakan , Paust Hans-Joachim , Sivayoganathan Amirrtavarshni , Linke Alexandra , Wegscheid Claudia , Wiech Thorsten , Huber Tobias B. , Meyer-Schwesinger Catherine , Bonn Stefan , Prinz Immo , Panzer Ulf , Tiegs Gisa , Krebs Christian F. , Neumann Katrin
Published: March 2023

Significance Statement

T-cell infiltration is a hallmark of crescentic GN (cGN), often caused by ANCA-associated vasculitis. Pathogenic T-cell subsets, their clonality, and downstream effector mechanisms leading to kidney injury remain to be fully elucidated. Single-cell RNA sequencing and T-cell receptor sequencing revealed activated, clonally expanded cytotoxic CD4+ and CD8+ T cells in kidneys from patients with ANCA-associated cGN. In experimental cGN, kidney-infiltrating CD8+ T cells expressed the cytotoxic molecule, granzyme B (GzmB), which induced apoptosis in renal tissue cells by activation of procaspase-3, and aggravated disease pathology. These findings describe a pathogenic function of (clonally expanded) cytotoxic T cells in cGN and identify GzmB as a mediator and potential therapeutic target in immune-mediated kidney disease.

Background

Crescentic GN (cGN) is an aggressive form of immune-mediated kidney disease that is an important cause of end stage renal failure. Antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis is a common cause. T cells infiltrate the kidney in cGN, but their precise role in autoimmunity is not known.

Methods

Combined single-cell RNA sequencing and single-cell T-cell receptor sequencing were conducted on CD3+ T cells isolated from renal biopsies and blood of patients with ANCA-associated cGN and from kidneys of mice with experimental cGN. Functional and histopathological analyses were performed with Cd8a
−/− and GzmB
−/− mice.

Results

Single-cell analyses identified activated, clonally expanded CD8+ and CD4+ T cells with a cytotoxic gene expression profile in the kidneys of patients with ANCA-associated cGN. Clonally expanded CD8+ T cells expressed the cytotoxic molecule, granzyme B (GzmB), in the mouse model of cGN. Deficiency of CD8+ T cells or GzmB ameliorated the course of cGN. CD8+ T cells promoted macrophage infiltration and GzmB activated procaspase-3 in renal tissue cells, thereby increasing kidney injury.

Conclusions

Clonally expanded cytotoxic T cells have a pathogenic function in immune-mediated kidney disease.
Deserción en la Educación Superior Rural: Análisis de Causas desde el Pensamiento Sistémico
Authors: Guzmán Rincón Alfredo , Barragán Moreno Sandra , Cala-Vitery Favio , Segovia-García Nuria
Published: March 2023

La deserción limita los beneficios personales y sociales de la educación. En este sentido, los estados e instituciones educativas buscan prevenir y mitigar este fenómeno mediante el desarrollo de políticas públicas e institucionales, sin embargo, la complejidad del fenómeno es tal, que estas políticas son insuficientes y no se encuentran del todo articuladas con las realidades de los estudiantes, de ahí que persistan las elevadas tasas de deserción. Así, el objetivo del presente artículo fue establecer las causas de la deserción estudiantil en la educación superior rural a partir de un modelo conceptual basado en pensamiento sistémico a partir de las narrativas de un grupo de estudiantes colombianos. Para su cumplimiento se realizó un estudio cualitativo, en el que participaron 19 estudiantes. El análisis se realizó mediante codificación abierta para la identificación de variables que incidían en este fenómeno educativo, y se finalizó con un modelo basado en diagrama de bucles causales. Los resultados evidenciaron que las obligaciones laborales y familiares, la condición financiera del estudiante y el rol de los docentes son las variables más recurrentes en los participantes. Finalmente, a partir de las variables encontradas y el modelo, se proponen acciones que deben ser incorporadas en el marco de las políticas públicas e institucionales para prevenir y mitigar el fenómeno de la deserción.
Bootstrap Based Diagnostics for Survival Regression Model with Interval and Right-Censored Data
Authors: Arasan Jayanthi , Midi Habshah
Published: March 2023

This research proposes a new approach based on the bias-corrected bootstrap harmonic mean and random imputation technique to obtain the adjusted residuals (Hboot) when a survival model is fit to right- and interval-censored data with covariates. Following that, the model adequacy and influence diagnostics based on these adjusted residuals, case deletion diagnostics, and the normal curvature are discussed. Simulation studies were conducted to assess the performance of the parameter estimate and compare the performances of the traditional Cox-Snell (CS), modified Cox-Snell (MCS) and Hboot at various censoring proportions (cp) and samples sizes ($n$) using the log-logistic and extreme minimum value regression models with right- and interval-censored data. The results clearly indicated that Hboot outperformed other residuals at all levels of cp and $n$, for both models. The proposed methods are then illustrated using real data set from the COM breast cancer data. The results indicate that the proposed methods work well to address model adequacy and identify potentially influential observations in the data set.
Faculty’s Access to Information and Communication Technologies in Colleges and Universities in Central Visayas, Philippines
Authors:   the College of Teacher Education of Cebu Normal University in Cebu City, Philippines, Sanchez Joje Mar P. , Sumalinog Gino G. , Mananay Janet A. , Baguia Mathea M. , Goles Charess E. , Alejandro Isidro Max V.
Published: March 2023

Information and communications technology (ICT) is a useful tool in the modern world, becoming indispensable, particularly in the educational setting. With this, the researchers looked into the ICT access of the faculty in colleges and universities in Central Visayas, Philippines. This access was measured through Faculty’s ICT Access (FICTA), administered through online surveys. Study findings revealed that faculty had physical access to ICT, evidenced by their acquisition of laptop computers, smartphones, Internet connections, and office suite software. Moreover, teachers were highly motivated to use ICT and highly skilled to operate, search, and strategize online. They also had high usage of ICT in their general and instructional work. Furthermore, motivation, skills, and usage access were significantly associated with one another. In conclusion, teachers have access to ICT which made their teaching better. Better digital infrastructure, more capability training, and encouraged utilization of ICT are recommended at the higher educational level in the country.
El proceso de comercialización de concentrados de cobre: una mirada a América Latina y el cumplimiento fiscal
Authors: Reyes-Tagle Gerardo , Guajardo Juan Carlos
Published: March 2023

El objetivo del presente trabajo es ampliar la base de conocimiento sobre el papel que desempeña la industria minera en las economías de América Latina y, en consecuencia, sobre su importancia en la recaudación fiscal. En particular, busca aportar información sobre el proceso de comercialización de concentrados de cobre, cuyo grado de especialización y complejidad hace necesario un conocimiento adecuado que permita a los responsables de la supervisión y el control de estos concentrados minimizar los riesgos en la estimación de la base tributaria de los países que los exportan. Para ello, esta publicación examina diferentes elementos clave, desde los procesos productivo y de comercialización del cobre, la manera de determinar su valor comercial y las principales cláusulas contractuales que se utilizan a nivel global, hasta los mecanismos de control y tratamiento fiscal más importantes, así como las buenas prácticas internacionales identificadas en los países con mayor producción de este mineral a nivel mundial. Entre estas últimas se cuentan, por ejemplo, la formalización y el registro de los productores, el acceso a información comercial, societaria y de mercado, y el empleo de metodologías de riesgo específicas, entre otras. En suma, es posible afirmar que los temas involucrados con la producción y la comercialización de concentrados de cobre revisten una gran complejidad. Por esa razón, resulta fundamental efectuar una planificación cuidadosa de la gestión de carrera de los funcionarios encargados de modo que permita su alineación con los intereses fiscales, como el control de la evasión y la corrupción, así como afrontar exitosamente los desafíos que presentan las tareas de coordinación entre las diversas instituciones del Estado.
N-Acetylcysteine Mediated Regulation of MnSOD, UCP-2 and Cytochrome C Associated with Amelioration of Monocrotophos-Induced Hepatotoxicity in Rats
Authors: Singh Jagjeet , Phogat Annu , Kumar Vijay , Malik Vinay
Published: March 2023

Pesticides are now a risk to the environment and public health. Monocrotophos (MCP) is known to cause organ toxicity and impart degenerative effects at cellular levels. N-acetylcysteine (NAC) is a natural antioxidant having various prophylactic properties. Male Wistar rats were given NAC (200 mg/kg b.wt), MCP (0.9 mg/kg b.wt) and NAC followed by MCP; intragastrically for 28 consecutive days. Regulation of MnSOD, UCP-2 and cytochrome c was analyzed by western blotting and polymerase chain reaction. Histology, electron microscopy and weight parameters were evaluated in the liver. MCP exposure significantly decreased body weight gain, relative liver weight, and structural changes. Altered MnSOD protein expression, decreased transcription of UCP-2 and MnSOD, and released cytochrome c indicated that oxidative stress is involved in MCP exposure. Treatment of NAC to MCP-exposed rats normalized the weight and structural changes, restored MnSOD and UCP-2 levels and prevented the release of cytochrome c. The present study suggests that the regulation of UCP-2, MnSOD and cytochrome c is involved in NAC efficacy against MCP toxicity. These findings illustrate that NAC can serve as a potential therapeutic agent for toxicity and oxidative stress in mammals.
INVERNO VERSUS ANTIMICROBIANOS: INTERAÇÕES MEDICAMENTOSAS DE ACORDO COM O PERFIL DAS PRESCRIÇÕES MÉDICAS DISPENSADAS EM UMA FARMÁCIA COMUNITÁRIA DO SUL DE SANTA CATARINA
Authors: Scarabelot Gabriela , Borges Marília Schutz
Published: March 2023

Medicamentos são parte importante da atenção à saúde e o acesso a estes, é direito humano fundamental defendido por lei. No contexto de uso racional de medicamentos, a prescrição é fator importante para que isto ocorra. Entretanto, diversos estudos demonstram erros de prescrição, como possíveis e graves interações medicamentosas. Por isto, temos como objetivo neste trabalho determinar o perfil das interações medicamentosas de acordo com as prescrições a fim de promover o uso racional de medicamentos identificando e prevenindo possíveis interações medicamentosas. Realizou-se um estudo retrospectivo quantitativo, envolvendo uma análise documental das prescrições médicas atendidas dispensadas no período de 21 de junho de 2018 à 22 de setembro de 2018. Observamos que, das 345 prescrições analisadas, apenas 6,67% (n=23) apresentaram potenciais interações envolvendo antimicrobianos.
The Façade of Green Lifestyles: Outdoor Recreation and Greenhouse Gas Emissions in Norway
Authors: Aritza Alaitz
Published: March 2023

Outdoor recreation is a popular leisure activity many consider to be an environmentally friendly practice that promotes care for the natural world. This study uses a survey to investigate transportation use and gear purchasing habits among Norwegians who participate regularly in outdoor life. Using a hybrid life-cycle assessment, it was estimated that the average participant releases between 3.4 and 4.7 tons of carbon dioxide equivalent emissions per year due to outdoor recreation activities. This is equal to around one fifth of the average Norwegian’s yearly greenhouse gas emissions and is more than double the per capita boundary required to limit global temperature rise to 2 degrees Celsius. Regression analysis highlights level of disposable income as the best predictor of environmental load. This indicates that the façade of a green lifestyle based on ecological values masks the global environmental consequences of excessive consumption related to outdoor recreation activities.
Apel o modułowe ujmowanie etyki biznesu. Podstawy etycznego uzasadniania decyzji ekonomicznych
Authors: Schweitzer Marcell
Published: March 2023

We regard this article as a plea for the modular design of a practice-related discipline of business
ethics, in which we analyse under what conditions economic decisions and actions in firms – regardless
of their content – are to be understood as morally right. Following the clarification of certain
fundamentals of the ethical substantiation of economic decisions, we describe a system of modules
as the epistemological frame of reference that designs the formal analysis. We examine in detail
the contribution of the descriptive module (as a conception of representation), the theoretical module
(as a conception of explanation and prediction), the pragmatic module (as a conception of designing)
and the normative module (as a conception of value-judgment) to the ethical substantiation
of economic decisions and actions.
As a conclusion of the formal analysis, we show that the ideal of the virtuous merchant as a basis
of the ethics of conviction for the substantiation of economic decisions offers, at best, an imperfect
solution. Following this, we give reasons why a practice-related discipline of business ethics as ethics
of responsibility for the substantiation of economic decisions is particularly efficient. The main reason
for this lies in the fact that this discipline integrates relevant insights (statements) from the descriptive,
theoretical, pragmatic and normative modules into a self-contained system of statements. We ensure
the systematic complementation of business administration by the discipline of business ethics
by relating the statements of both systems to the same decisions concerning scarce goods that form
the subject of business administration, and close factual and methodical relations between
the two systems.
Ekonomia narodowa a etyka w ujęciu Stanisława Głąbińskiego
Authors: Szymański Zdzisław
Published: March 2023

Stanisław Głąbiński (1862-1941), professor of Lviv University and the author
of the two-volume ‘National Economics (‘Ekonomika narodowa’), was one
of the main representatives of the historical-national approach in Polish economics.
The study of national economics which he created was divided into general
economics, i.e. economic theory, and practical economics, referred to as economic
and social policies. Głąbiński emphasizes that there is a close relationship between
the latter and ethics. Before the development of economic theory, economic
thought was normative, because of its close relationship to ethics. However, it was
not the history of economic theory, but the history of the notion of economic
politics and of its practical application. Due to the social nature of ethics, there
are also specific relations between it and theoretical economics. In modern countries
finding a solution to the so-called social question has become a common task
of economics and ethics.
Ethical topics are also contained in the content of the category ‘social resources’,
in which the social determinants of human economic activity find their
fullest reflection. This applies in particular to the category of moral resources,
which illustrates the functioning of state bodies and public institutions, the state
of education, the prevailing habits and the customs and the character of the nation.
Determination of alteration zones applying fractal modeling and Spectral Feature Fitting (SFF) method in Saryazd porphyry copper system, central Iran
Authors: BEHBAHANI Behzad , HARATI Hamid , LOTFI Mohammad , AFZAL Peyman
Published: March 2023

The target of this research is recognition of the alteration zones utilizing concentration-area fractal methodology according to the reflection of the main minerals of each alteration zone that enhanced by Spectral Feature Fitting (SFF) method due to Advanced Space-borne Thermal Emission and Reflection Radiometer (ASTER) satellite images in Saryazd porphyry system, central Iran. The alterations and mineralization developed in Eocene volcanics. Remote sensing results achieved by the SFF method and Concentration -Area (C - A) fractal modeling represent different parts of propylitic, argillic and phyllic alteration zones due to their intensity and pixel values. In addition, the results reveal that there is a ring-shaped structure in the alteration zones, which are correlated with results, derived from X-Ray Diffraction (XRD) analyses and field observations.
The Effectiveness of Peer Group WhatsApp on Adolescent Knowledge and Attitudes about Risky Sexual Behavior
Authors: Arisani Greiny , Wahyuni Seri
Published: March 2023

Background: Nowadays problems of teenagers are very complex and worrying, both those that arise from within themselves and from outside themselves. Various internal and external factors that affect adolescents will also have an impact on adolescents to have negative and unhealthy attitudes and behaviors (high-risk behaviors). Efforts to increase knowledge and attitudes in adolescents can be used in preventing risky sexual behavior through WhatsApp peer groups. Objective: This study analyzes the effectiveness of the WhatsApp peer group on the knowledge and attitudes of adolescents about risky sexual behavior in Isen Mulang Senior High School, Palangka Raya City. Methods: This study is a quasi-experimental study with two groups, pretest-posttest with a control group design which was carried out from July to September 2020. The population in this study were all adolescents who were in the age range of 15-21 years in Isen mulang Senior High School at SMA Isen Mulang, Palangka Raya city numbered 169 people with the sampling technique in this study using consecutive sampling with a sample of 31 respondents in the intervention group and 31 respondents in the control group. Results: There is a significant difference in the average value of knowledge (P-value = 0.000) and attitude score (P-value = 0.000) before and after the intervention in each group, there is a significant difference in increasing knowledge (P-value = 0.045) and attitude (P-value = 0.048) between the intervention group and the control group. The average increase in knowledge scores and attitude scores of the intervention group was higher than the control group. Conclusion: WhatsApp peer groups are considered effective in increasing adolescent knowledge and attitudes about risky sexual behavior. WhatsApp peer groups can be used as dynamic communication media and become one of the alternative choices in providing health education to adolescents other than face-to-face.
Cathepsin K: both a likely biomarker and a new therapeutic target in lymphangioleiomyomatosis?
Authors: Marchand-Adam Sylvain , Pronost Marion , Saidi Ahlame , Lecaille Fabien , Lalmanach Gilles
Published: March 2023

Lymphangioleiomyomatosis (LAM) is a rare disease which is characterized by cystic lung destruction and lymphangiomas, and is associated with a high risk of osteoporosis-related bone fractures. Its diagnosis is based on pulmonary anatomopathological criteria combined with chest computed tomography. VEGF-D is the only serum diagnostic biomarker used in clinic, while inhibition of the mTOR pathway by rapamycin is currently the only reference therapy for LAM. Human cathepsin K (CatK), a potent collagenase predominantly found in osteoclasts, is considered as a valuable target for anti-osteoporosis and bone cancer therapy. Recently, CatK, which is overexpressed in lung cysts, was proposed as a putative LAM biomarker. Moreover, CatK may take part in the LAM pathophysiology by participating in pulmonary cystic destruction and bone degradation. Accordingly, targeting of collagenolytic activity of CatK by exosite-binding inhibitors in combination with mTOR inhibition could represent an innovative therapeutic option in reducing lung destruction in LAM.
Critical Thinking Skills Improvement of Students Through Guided Inquiry Learning Model with Scientific Approach
Authors: Affilia Rheima , Komariyah Laili , Efwinda Shelly
Published: March 2023

The COVID-19 pandemic pushed many schools to create hybrid learning systems due to drastic changes in the learning environment. Technology and knowledge have advanced swiftly in the 21st century. As the foundation of education, the school is expected to foster students' 4C skills, one of which is critical thinking. This study aimed to analyze how students' critical thinking skills changed after studying harmonic motion using the guided inquiry model and scientific approach. The study used a quantitative method with the pre-experimental design's one-group pre-test post-test procedure. A 10-question essay was used to obtain data from 31 students in grade X IPA 3. The findings indicated that students' critical thinking skills improved, with an N-Gain score of 0.72. As well as implications for this study, there were significant differences in critical thinking participants were educated with the T-test sample pair after using the santific suppression with the guided inquiry model.
HASHTAG AS A UNIT OF INTERNET DISCOURSE: COGNITIVE AND PRAGMATIC PERSPECTIVE
Authors:   Financial University under the Government of Russian Federation, Department of Foreign Languages and Intercultural Communication, Yudina N.V. , Seliverstova O.A. ,   Financial University under the Government of Russian Federation, Department of Foreign Languages and Intercultural Communication
Published: March 2023

Internet discourse is a multifaceted phenomenon studied by a number of sciences from different perspectives. In any type of discourse, the choice of syntactical structure and lexical units is determined by pragmatics of communication and is dependent on the speaker’s intention. The same is true for blogs. This paper undertakes to look into cognitive mechanisms underlying the creation or choice of hashtags in Instagram blogs. The analysis was based on collected corpus of 2000 hashtags including those in English and Russian. Instagram accounts under study included those with the number of followers ranging from 5000 to 200 million. Among them were accounts of celebrities (who are famous due to their profession and take blog as a way of communication with their fans) and “proper” bloggers (whose blogs are their job and main activity). The study resulted in a classification of hashtags distinguished with regard to their form, communicative intention of the author and cognitive mechanisms employed in choosing them. Thus 1) prototype hashtags aim to express involvement or belonging and may be based on the cognitive mechanism of implication; 2) performative hashtags are based on profiling and show intention of highlighting one component of a blogger’s image; 3) imperative hashtags are based on profiling as well and aim to encourage some action on the part of followers; 4) metaphoric hashtags are based on cognitive metaphors and usually serve self-representation; 5) topical hashtags include a number of subtypes and may be based on generalization, perspectivization, focusing or elaboration and serve as topical markers or means of consolidation with other topically related accounts; 6) category hashtags are based on concretization and serve to navigate within one blog; 7) summarizing hashtags are based on inference and aim to provide a summary or a conclusion; 8) metatext hashtags are based on composition and seek to link with already known hashtags adding new characteristics, knowledge or meaning to the precedent message. The choice of hashtags by each blog author appears to be dependent on the number of followers and the type of blog.
SPECIFICS OF EVALUATION IN ENGLISH MEDIA TEXTS (by the example of “opinion”, “analysis” and “editorial” sections)
Authors:   MGIMO University, Nikonova E.A.
Published: March 2023

The study investigates the representation of the vaccine against COVID-19 in “editorial”, “opinion” and “analysis” articles. The study draws on the appraisal model as a linguistic tool to analyze the attitudinal language of the articles, the differences in which have the potential to be the ground for differentiating “opinion”, “editorial”, and “analysis” texts. The selected 30 articles belong to the period from March 2020 to January 2021, when the importance of the vaccine was unprecedented and all political and economic factors moved to the background. The findings indicate no significant differences in the types of evaluations used, though demonstrate some tendencies that constitute grounds for further research in the field: 1) “analysis” texts draw on less evaluative elements than “editorial” and “opinion”; 2) “opinion” texts demonstrate a balance of appreciation and judgment; 3) there is a dominance of judgment in “editorial” texts. The paper demonstrates that all texts judge the vaccines as effective tools and avoid emotional or negative evaluations.
ETHNIC AND GENDER STEREOTYPES OF RUSSIAN AND CHINESE
Authors:   Perm State Univerrsity, Erofeeva E.V. , Chen Yao ,   Perm State Univerrsity
Published: March 2023

The article considers variation of social stereotypes within four ethnic-gender groups: Chinese males, Chinese females, Russian males, Russian females. The authors carried out the study as a cross-group experiment using the semantic differential method. The participants (30 pers. in each group, 120 pers. in total) evaluated the attributes of appearance, character and intellect of each group considered. The data analysis showed complex interaction between the ethnic and gender factors: the ethnic factor is more important for the Chinese subjects (both males and females), while the gender factor is the leading one for the Russian females. The types of attributes that are stereotypically referred to different groups and are preferably used by different groups also vary. Thus, appearance attributes are mostly used for describing females; the Chinese participants evaluate ethnic-gender groups using the character and appearance attributes; the Russian females evaluate ethnic-gender groups using the intellect attributes. Chinese and Russian females, both as an evaluating subject and an object of evaluation, are more “stereotypical” (females evaluate other groups using a wider range of attributes, and stereotypes about females include more attributes than stereotypes about males). Males as an object of evaluation are less stereotyped than females and, at the same time, perceive social groups less stereotypically. Almost no stable stereotypes were revealed about the Russian males. Overall, the results indicate that in each particular case of social categorization attributing stereotype features to different groups is a complex cognitive process determined by a unique combination of various factors.
TEXT TOOLS FOR ARCHETYPING THE MODEL OF THE WORLD IN THE SYSTEM OF THE LATEST MEDIA
Authors:   Derzhavin Tambov State University, Zvereva E.A. , Shesterina A.M. ,   Lomonosov Moscow State University; Derzhavin Tambov State University
Published: March 2023

The newest media feel the constant need both to attract the attention of the audience and to form a stable circle of subscribers. To achieve this goal, they attempt to appeal to the basic values of users. One of these forms of work is the archetypization of plots and characters of media works. The paper is based on the method of content analysis. We also used comparative-typological and historical-functional methods; an analysis of textual means of archetyping the model of the world in the latest media is carried out, both at the level of printed works and at the level of modern audiovisual formats. The research material is the most popular print online media and video blogs of the Russian-speaking sector of the Internet in 2021 and in particular - the blog of the stylist Alexander Rogov. In the course of the study, we explored the archetypal images and plots most often broadcast by them: transformation, the struggle with the titan, adventure, systematization of philosophical categories, chicanery, etc. Examples of the most particular directions in the modification of archetypal images and plots are given. The conclusion is made about the multiplot, often manifested in network content. The results of the study capture the dominant characteristics of modern mass communication and can be extrapolated to other textual realities that characterize the socio-cultural background of modern society.
THE ORIGINS OF LINGUISTIC AND COGNITIVE RESEARCH IN THE SCHOOL OF ANGLISTICS OF SPbU
Authors:   Saint Petersburg State University, Myachinskaya E.I. ,   Saint Petersburg State University, Emelianova O.V. ,   Saint Petersburg State University, Petukhova T.I. ,   Saint Petersburg State University
Published: March 2023

The article, devoted to the 300th anniversary of St. Petersburg State University, examines the formation and functioning of the anthropocentric linguistic paradigm on the example of the development of the philological school of English Studies at the University. The comprehensive linguocognitive research, which is currently being successfully conducted within the School of English Studies by scholars from the Department of English Philology and Language and Culture Studies and the Department of English Philology and Translation, is the result of the gradual development of a linguistic paradigm whose origins were laid down by lecturers at the beginning of the last century. We focused in particular on preserving the origins and century-old traditions of the School of Anglistics in modern linguocognitive and cultural studies, as well as on the University’s philologists unequivocal contribution to investigating the singularity of English-language space at the level of its semantic, linguo-cultural and pragmacognitive characteristics.
Role of the Gut Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence
Authors: Bragazzi Maria Consiglia , Venere Rosanna , Vignone Anthony , Alvaro Domenico , Cardinale Vincenzo
Published: March 2023

The “Gut-Liver Axis” refers to physiological bidirectional interplay between the gut and its microbiota and the liver which, in health, occurs thanks to a condition of immune tolerance. In recent years, several studies have shown that, in case of modifications of gut bacterial homeostasis or impairment of intestinal barrier functions, cholangiocytes, which are the epithelial cells lining the bile ducts, activate innate immune responses against gut-derived microorganisms or bacterial products that reach the liver via enterohepatic circulation. Intestinal dysbiosis or impaired intestinal barrier functions expose cholangiocytes to an increasing amount of microorganisms and may exacerbate inflammatory responses thus leading to fibrotic remodeling of the organ. The present review focuses on the role of the gut liver axis in the pathogenesis of cholangiopathies.
Condition Monitoring in the Advances of Industry 4.0- Case Study
Authors: Shaalan Abdu , Baglee David
Published: March 2023

Technology-enabled maintenance via sensors and the internet of things (IoT) technologies is seen as the “new maintenance strategy”. The aim is to use these technologies to focus on unnecessary breakdowns and increase levels of asset availability where the existing of a dedicated team to maintain or data on asset condition is limited, useless or full of noise. This paper presents the integration of various sensing nodes within an automated laser cutting machine for monitoring of critical components’ conditions. The integrated system provides a centralised platform for data collection from various sensors and provides early failure detection mechanism based on specified set points with alert mechanisms utilising a custom dashboard for data visualisation. The research highlights the required stages for the identification of the appropriate components and sensory devices for the development of efficient monitoring environment.
Establishment of a Novel Anti-Human CCR6 Monoclonal Antibody C6Mab-19 with the High Binding Affinity in Flow Cytometry
Authors: Tanaka Tomohiro , Kitamura Kaishi , Suzuki Hiroyuki , Kaneko Mika K. , Kato Yukinari
Published: March 2023

CC chemokine receptor 6 (CCR6) is a member of the G protein-coupled receptor (GPCR) family that is highly expressed in B lymphocytes, effector and memory T cells, regulatory T cells, and immature dendritic cells. CCR6 has been revealed to have important functions in many pathological conditions, such as cancer, intestinal bowel disease, psoriasis, and autoimmune diseases. The only CCR6 chemokine ligand, CC motif chemokine ligand 20 (CCL20), is also involved in pathogenesis by interacting with CCR6. The CCL20/CCR6 axis is drawing attention as an attractive therapeutic target for various diseases. In this study, we developed novel monoclonal antibodies (mAbs) against human CCR6 (hCCR6) using the peptide immunization method, which are applicable to flow cytometry and immunohistochemistry. The established anti-hCCR6 mAb, clone C6Mab-19 (mouse IgG1, kappa), reacted with hCCR6-overexpressed Chinese hamster ovary-K1 (CHO/hCCR6), HepG2 (human liver carcinoma), and HuH-7 (human differentiated hepatoma) cells in flow cytometry. The dissociation constant (KD) of C6Mab-19 was determined as 3.0 × 10−10 M for CHO/hCCR6, 6.9 × 10−10 M for HepG2, and 1.8 × 10−10 M for HuH-7. Thus, C6Mab-19 could bind to exogenously and endogenously expressed hCCR6 with extremely high affinity. Furthermore, C6Mab-19 could stain formalin-fixed paraffin-embedded lymph node tissues from a patient with non-Hodgkin lymphoma by immunohistochemistry. Therefore, C6Mab-19 is suitable for detecting hCCR6-expressing cells and tissues, and could be useful for pathological analysis and diagnosis.
Human Activity Recognition-based Cyber-Physical System Security Through IoT-Cloud Computing
Authors: Achar Sandesh , Faruqui Nuruzzaman , Whaiduzzaman Md , Awajan Albara , Alazab Moutaz
Published: March 2023

Cyber-physical security is vital for protecting key computing infrastructure against cyber attacks. Individuals, corporations, and society can all suffer considerable digital asset losses due to cyber attacks, including Data loss, theft, financial loss, reputation harm, company interruption, infrastructure damage, ransomware attacks, and espionage. A cyber-physical attack harms both digital and physical assets. Cyber-physical system security is more challenging than software-level cyber security because it requires physical inspection and monitoring. This paper proposes an innovative and effective algorithm to strengthen Cyber-Physical Security (CPS) with minimal human intervention. It is a Human Activity Recognition (HAR)-based approach where a GoogleNet-BiLSTM network hybridization has been used to recognize suspicious activities in cyber-physical infrastructure perimeter. The proposed HAR-CPS algorithm classifies suspicious activities from real-time video surveillance with an average accuracy of 73.15%. It incorporates Machine Vision at the IoT Edge (Mez) technology to make the system latency tolerant. Dual-layer security has been ensured by operating the proposed algorithm and GoogleNet-BiLSTM hybrid network from a cloud server, which ensures the security of the proposed security system. The innovative optimization scheme makes it possible to strengthen cyber-physical security with $4.29 per month only.
One-Week Elderberry Juice Treatment Increases Carbohydrate Oxidation After a Meal Tolerance Test and is Well Tolerated in Adults: A Randomized Controlled Pilot Study
Authors: Rust Bret M. , Riordan Joseph O. , Carbonero Franck G. , Solverson Patrick M.
Published: March 2023

Obesity in the United States continues to worsen. Anthocyanin-rich fruits and vegetables provide a pragmatic dietary approach to slow its metabolic complications. Given American diet patterns, foods with high anthocyanin content could address dose-response challenges. In a placebo-controlled, randomized, crossover pilot study, determine the effect of 100% elderberry juice on measures of indirect calorimetry (IC), and insulin sensitivity/glucose tolerance. Overweight and obese adults were randomized to a 5-week study which included two 1-week periods of twice-daily elderberry juice (EBJ), or sugar-matched placebo consumption separated by a 3-week washout period. Following each 1-week test period, IC and insulin sensitivity/glucose tolerance was measured with a 3-hour meal tolerance test (MTT). Treatment differences were tested with linear mixed modeling. 22 prospective study volunteers (18F/4M) attended recruitment meetings, 10 volunteers completed the protocol, and 9 were analyzed for treatment differences. EBJ was well tolerated and compliance was 99.6%. Six IC measures (intervals) were created which coincided with 10-20 minute gaseous samplings in-between MTT blood samplings. Average CHO oxidation was significantly higher during the MTT after 1-week EBJ consumption (3.38 vs. 2.88 grams per interval, EBJ vs. placebo, p = 0.0113). Conversely, average fat oxidation was significantly higher during the MTT after 1-week placebo consumption (1.17 vs 1.47 grams per interval, EBJ vs. placebo, p = 0.0189). This was in-line with a significantly lower average respiratory quotient after placebo treatment (0.87 vs. 0.84, EBJ vs. placebo, p = 0.0114). Energy expenditure was not different. There was no difference in serum glucose or insulin response between treatments. This pilot study of free-living volunteers describes significant change in IC but not insulin sensitivity with an EBJ intervention. Controlled feeding and increased sample size will help determine the utility of EBJ on these outcomes.
Improving Soil Stability with Alum Sludge: An AI-Enabled Approach for Accurate Prediction of California Bearing Ratio
Authors: Baghbani Abolfazl , Nguyen Minh Duc , Alnedawi Ali , Milne Nick , Baumgartl Thomas , Abuel-Naga Hossam
Published: March 2023

Alum sludge is a byproduct of water treatment plants and its use as a soil stabilizer has gained increasing attention due to its economic and environmental benefits. Its application has been shown to improve the strength and stability of soil, making it suitable for various engineering applications. However, to go beyond just measuring the effects of alum sludge as a soil stabilizer, this paper explores the use of artificial intelligence (AI) methods to predict the California bearing ratio (CBR) of soils stabilized with alum sludge. Three AI methods, including two black box methods (artificial neural network and support vector machines) and one grey box method (genetic programming), were used to predict CBR based on a database with nine input parameters. The results showed that all three AI models were able to predict CBR with good accuracy, with coefficient of determination (R2) values ranging from 0.94 to 0.99 and mean absolute error (MAE) values ranging from 0.30 to 0.51. In a novel approach, the genetic programming method was used to produce an equation to estimate CBR, which included seven inputs and accurately predicted CBR. The analysis of sensitivity and importance of parameters showed that the number of hammer blows for compaction was the most important parameter, while the parameters for maximum dry density of soil and mixture were the least important. This study suggests that AI methods can effectively predict the performance of alum sludge as a soil stabilizer, and the proposed equation using genetic programming can be a useful tool for predicting CBR.
Is Smart Working Beneficial for Workers' Well-being? A Longitudinal Investigation of Smart Working, Workload and Hair Cortisol/Dehydroepiandrosterone Sulfate during the COVID-19 Pandemic
Authors: Falco Alessandra , Girardi Damiano , Elfering Achim , Peric Tanja , Pividori Isabella , Dal Corso Laura
Published: March 2023

Building on the job demands-resources (JD-R) and the allostatic load (AL) models, in this study we investigated the role of smart working (SW) in the longitudinal association between workload/job autonomy (JA) and a possible biomarker of work-related stress (WRS) in the hair, namely the cortisol to dehydroepiandrosterone sulphate (DHEA(S)) ratio, during the COVID-19 pandemic. Overall, 124 workers completed a self-report questionnaire (i.e., psychological data) at Time 1 (T1) and collected a strand of hair (i.e., biological data) three months later (Time 2, T2). Results from moderated multiple regression analysis showed that smart working at T1 was negatively associated with hair cortisol/DHEA(S) ratio at T2. Additionally, the interaction between workload and SW was significant, with workload at T1 being positively associated with hair cortisol/DHEA(S) ratio at T2 among smart workers. Overall, this study indicates that SW can be conceived as a double-edged sword, with both positive and negative consequences on employee well-being. Furthermore, our findings suggest that hair cortisol/DHEA(S) ratio is a promising biomarker of WRS. Practical implications that organizations and practitioners can adopt to promote organizational well-being are discussed.
Implementation of a new flux rotor based on model reference adaptive system for sensorless direct torque control modified for induction motor
Authors: Saifi R.
Published: March 2023

Introduction. In order to realize an efficient speed control of induction motor, speed sensors, such as encoder, resolver or tachometer may be utilized. However, some problems appear such as, need of shaft extension, which decreases the mechanical robustness of the drive, reduce the reliability, and increase in cost. Purpose. In order to eliminate of speed sensors without losing. Several solutions to solve this problem have been suggested. Based on the motor fundamental excitation model, high frequency signal injection methods. The necessity of external hardware for signal injection and the adverse influence of injecting signal on the motor performance do not constitute an advantage for this technique. Fundamental model-based strategies method using instantaneous values of stator voltages and currents to estimate the rotor speed has been investigate. Several other methods have been proposed, such as model reference adaptive system, sliding mode observers, Luenberger observer and Kalman filter. The novelty of the proposed work consists in presenting a model reference adaptive system based speed estimator for sensorless direct torque control modified for induction motor drive. The model reference adaptive system is formed with flux rotor and the estimated stator current vector. Methods. The reference model utilizes measured current vector. On the other hand, the adjustable model uses the estimated stator current vector. The current is estimated through the solution of machine state equations. Practical value. The merits of the proposed estimator are demonstrated experimentally through a test-rig realized via the dSPACE DS1104 card in various operating conditions. The experimental results show the efficiency of the proposed speed estimation technique. Experimental results show the effectiveness of the proposed speed estimation method at nominal speed regions and speed reversal, and good results with respect to measurement speed estimation errors obtained.
HONG KONG, SINGAPORE, UKRAINE – THE GENESIS OF INTERNATIONAL FINANCIAL CENTERS, THE DEVELOPMENT PROSPECT OF UKRAINE
Authors: Posokhov Igor , Novik Irina
Published: March 2023

The analysis of the features of the formation of the world financial centers of the Asia-Pacific region has been carried out. The study showed that the experience of Singapore and Hong Kong shows that attracting the best specialists can turn into a prosperous country, an international financial center. Ukraine has great opportunities and resources for development, it has the potential to become one of the leading financial centers, but for this it is necessary to adopt the experience of establishing existing international financial centers, take into account strengths and weaknesses, develop its own unique development concept, train qualified specialists, provide support all spheres of the country's activities for their development. The features of the formation of the world financial centers of the Asia-Pacific region are highlighted: an advantageous geographical position on the routes of regional and world trade, close communication ties with London and the presence of a preferential tax regime; Singapore is the financial center of the countries of Southeast Asia with a developed set of all components, namely: a developed gold market, a developed foreign exchange market; a developed bank lending market and a developed stock market; Hong Kong is the second international financial center in terms of IPO and the second stock market in Asia, has representative offices of 70 largest banks in the world; close partnership (cooperation) of the financial centers of Hong Kong and Shanghai and the support of investors and the market as a whole; the growth of the role of the world economy in the world and the development of the specialization

of international financial centers. Proposals for the gradual transformation of Ukraine into a global financial center have been developed: programs for state regulation and support of the education system to gradually improve the efficiency of the level of education: significant retraining of specialists, free state training programs, increased funding for the education sector; reform of the medical system is a factor contributing to attracting foreign investment, both in the medical and industrial sectors, solving the problem of labor migration of medical workers due to their low wages; development and implementation of anti-corruption measures; development of the financial sector of Ukraine (banking, stock, insurance market, etc.) in order to achieve the status of "International Financial Center"; creating conditions for attracting public and private investments in the financial sector, improving the legislative and tax policy of the financial sector.