bluuebunny/crossref_metadata_2025 huggingface dataset:
La limitada protección de la seguridad y salud en el trabajo de las fuerzas policiales.
Authors: Rojo Torrecilla Eduardo
Published: May 2022

El litigio encuentra su origen en sede judicial con la presentación de una demanda por parte de un miembro de la policía húngara de intervención rápida, a la que se había incorporado en enero de 2011. El interés de la resolución judicial radica en las muchas y claras restricciones que establece el TJUE para exceptuar la aplicación de la normativa sobre seguridad y salud en el trabajo, en concreto el art. 2 de la Directiva del Consejo, de 12 de junio de 1989, relativa a la aplicación de medidas para promover la mejora de la seguridad y de la salud de los trabajadores en el trabajo, a las fuerzas de policía. Corresponde al órgano jurisdiccional remitente determinar si las misiones llevadas a cabo por la unidad policial lo fueron en circunstancias de una gravedad y una magnitud excepcionales que justificaran la aplicación de la excepción prevista en el artículo 2, apartado 2, párrafo primero, de la Directiva 89/391

The dispute originated in a court case brought by a member of the Hungarian Rapid Intervention Police, which he joined in January 2011. The interest of the judicial decision lies in the many and clear restrictions established by the ECJ to exempt the application of the regulations on safety and health at work, specifically Article 2 of the Council Directive of 12 June 1989 on the introduction of measures to encourage improvements in the safety and health of workers at work, to the police forces. It is for the national court to determine whether the tasks carried out by the police unit were carried out in circumstances of exceptional gravity and magnitude which justified application of the derogation provided for in the first subparagraph of Article 2(2) of Directive 89/391.
Nulidad de convenio colectivo de empresa negociado por sección sindical no constituida conforme a los estatutos del sindicato
Authors: García Murcia Joaquín
Published: May 2022

Las secciones sindicales pueden negociar convenios colectivos si se constituyen conforme a lo dispuesto a los estatutos del sindicato, si ejercen esa competencia de acuerdo con las previsiones de tales normas internas, y si respetan el principio de correspondencia entre el ámbito de representación y el ámbito del convenio.

The union sections can negotiate collective agreements if three conditions are met: the sections must be created in accordance with the provisions of the union statutes, the negotiation must be carried out in accordance with the provisions of such internal regulations, and the principle of correspondence between the scope of representation and the scope of the agreement must be respected.
Las distintas finalidades de los reconocimientos médicos practicados a los trabajadores. Un apunte desde el Derecho comparado español y francés
Authors: Areta Martinez María
Published: May 2022

El artículo 20.4 del Estatuto de los Trabajadores faculta al empresario para verificar, mediante reconocimientos llevados a cabo por personal médico, el estado de salud que los trabajadores alegan para justificar sus faltas de asistencia al trabajo. La finalidad de esta medida, que el empresario puede externalizar, es controlar el absentismo laboral. El trabajador en situación de incapacidad temporal tiene obligación de someterse a este tipo de reconocimientos médicos, y su incomparecencia injustificada puede determinar que el empresario suspenda el abono de los derechos económicos que pudieran existir a su cargo. Conviene diferenciar los referidos reconocimientos médicos de otros que responden a distinta finalidad.

L'employeur peut demander au salarié en arrêt maladie de se soumettre à un contrôle médical afin de vérifier que son état de santé justifie l'arrêt prescrit par son médecin traitant; autrement dit, l'employeur peut faire réaliser une contre-visite médicale pour detérminer si l'arrêt de travail du salarié n'est plus médicalement justifié. On peut dire qu'il s'agit d'une méthode pour maîtriser l'absentéisme au travail. En cas d'absence injustifiée (sans motif légitime), l'employeur peut suspendre le versement du complément de salaire, en compensation des allocations de la Sécurité sociale. D'ailleurs, il est important de souligner que l'externalisation des contrôles médicaux est tout à fait legale. Finalmente, Il ne faut pas confondre ce contrôle médical patronal avec d'autres contrôles médicaux de l'état de santé des salariés, dont les finalités sont bien différentes.
Ropa de trabajo y peligro de contagio.
Authors: López Cumbre Lourdes
Published: May 2022

La presencia de riesgos relacionados con agentes biológicos durante el trabajo genera una obligación legal. Constatado el riesgo, la empresa deberá encargarse por sí misma o externalizando el servicio, de la desinfección o reposición de la ropa de trabajo y/o equipos de protección. En ningún caso deberá consentirse incrementar el riesgo de contagio encomendando tal labor al trabajador en su domicilio personal.

The presence of risks related to biological agents at work creates a legal obligation. Once the risk has been ascertained, the company must take care of the disinfection or replacement of working clothes and/or protective equipment, either by itself or by outsourcing the service. In no case should consent to increase the risk of contagion entrusting such work to the worker at his personal home.
ALMANCA ÖĞRETMEN ADAYLARININ ÖZ YETERLİK İNANÇLARI VE MESLEKİ TUTUMLARI
Authors: CAN Dilek , YÜCEL Fatma
Published: May 2022

Bu makalede Almanca öğretmen adaylarının Almanca öz yeterlik inançları ve öğretmenlik mesleğine ilişkin tutumları bazı değişkenler açısından incelenerek bunların arasındaki ilişkinin sonuçları belirlenerek sunulmuştur. Araştırmanın örneklemini Atatürk Üniversitesinin Yabancı Diller Eğitimi Anabilim Dalı Alman Eğitimi Bilim Dalı’nda 2019-2020 eğitim öğretim yılı güz yarıyılında hazırlık sınıfı, 1., 2., 3. ve 4. sınıfta eğitimlerini sürdüren öğretmen adayları oluşturmuştur. Yapılan bu araştırmada nicel araştırma modellerinden olan ilişkisel tarama modeli kullanılmıştır. Verileri toplamak için kişisel bilgi formu, öz yeterlik inanç ölçeği ve tutum ölçeği uygulanmıştır. Genel anlamda Almanca öğretmen adaylarının öz yeterlik inançlarının ve öğretmenlik mesleğine ilişkin tutumlarının cinsiyet, not ortalaması, mezun olunan lise türü ve üniversite öncesinde edinilen Almanca bilgisi değişkenlerine göre farklılaşmadığı görülmüştür. Yaş değişkenine göre okuma, dinleme ve konuşma alt boyutlarında ve genel toplamda anlamlı farklılaşmanın olduğu sonucuna varılmıştır. Almanca konuşulan bir ülkede bulunma değişkenine göre; sadece konuşma alt boyutunda anlamlı farklılaşma görülmüştür. Ayrıca Almanca öğretmen adaylarının öz yeterlik inançları ile mesleki tutumları arasında pozitif yönlü anlamlı bir ilişki b ulunmuştur. Öğretmen adaylarının öğretmenlik mesleğine yönelik tutumları ise değişkenlere göre farklılık göstermemiştir. Sınıf değişkenine göre okuma, yazma, dinleme ve konuşma alt boyutlarında en yüksek öz yeterlik inancı 4. sınıflarda gözlemlenmiştir.
Diseño de un evento como herramienta de relaciones públicas en la nueva normalidad post Covid-19.
Authors: Chaluisa Chaluisa Sonia Fabiola
Published: May 2022

La organización de todos los tipos de eventos fue cancelada a lo largo del año 2020, desde el 11 de marzo donde la Organización Mundial de la Salud (OMS) declaropandemia mundial al virus Covid-19. Esta situación ha afectado a la economía de muchas instituciones que se beneficiaban de las diferentes festividades para promocionar sus mayores atractivos turísticos, naturales o culturales. Este es el caso concreto del Gobierno Descentralizado Autónomo (GAD) de Latacunga, un municipio de la provincia de Cotopaxi-Ecuador, que desde hace algunos años se celebra la semana cultural denominado “Latacunga, histórica y literaria”, mismo que se lleva a cabo generalmente el mes de noviembre de cada año en la Casa de los Marqueses de la localidad como uno de los eventos por la emancipación latacungueña. El pasado año 2020, no se desarrolló el mencionado evento debido a que el gobierno impuso algunas restricciones con la finalidad de frenar los contagios por la Covid-19; aun así, las autoridades municipales, decidieron considerar dentro de su plan de festividades para el año 2021 en medio de la pandemia como forma de fomentar la semana cultural con un sin número de actividades. La presente investigación es una propuesta para la celebración del evento antes mencionado, mediante el acto denominada “Fiesta de la lectura 2021”, misma que se desarrollará con toda la logística técnica y administrativa que ello supone e incluido las medidas de bioseguridad Covid-19
A Survey of Dormitory Vietnamese University Students’ Lifestyle
Authors: Dung Phung Xuan , Vinh Nguyen Quang
Published: May 2022

The research is conducted to explore the reality of cultural life of Vietnamese boarding students at a public university in Ho Chi Minh City, Vietnam. Thereby, the authors made recommendations for a proper cultural life in the educational setting, which helped to enhance the living and studying environment for boarders. A 73-item questionnaire for assessing the present state of boarders was delivered to 638 students who were living in a few dormitories in the city. The question items are about learning behaviours (20 items), living habits (22 items), communication habits (21 things), and relationships (10 items). The results indicated that boarding students are serious about obeying school rules, but they are uninterested in studying activities. They are also disciplined and participate well in mandatory activities, but do not actively get involved in community volunteer activities and spend little time on morning exercises. Furthermore, students at boarding schools communicate in ways that are consistent with the social trends, and their romantic relationships are within acceptable bounds. In addition, their family relationships are quite secure; boarders are frequently proud of their parents' profession and adhere to the school's policies. Based on legal foundation, practical basis, norms, consultation with experts, and student feedback, 27 contents have been chosen to establish a cultural life for boarding students.
SYNTHESIS, CHARACTERIZATION AND MOLECULAR DOCKING STUDIES OF NOVEL 2-(5- BROMOBENZOFURAN-2-YL)-5-SUBSTITUTEDPHENYL-1,3,4-OXADIAZOLE DERIVATIVES
Authors: Sanjeeva P. , Rao B. Subba , Ramana P. Venkata , Raju C. Naga , Rajani V. , Prasad V. Kamala
Published: May 2022

A series of 2-(5-bromobenzofuran-2-yl)-5-substitutedphenyl-1,3,4-oxadiazoles were synthesized in good yields using 5- bromobenzofuran-2-carbohydrazide and characterized by analytical and spectral data. Auto Dock 4.0/ADT program was used to investigate binding interaction of oxadiazole derivatives to Asp kinase. Asp kinase of Mycobacterium tuberculosis (MTB) is a type II topoisomerase and is a well-established and validated target for the development of novel therapeutics. The search was based on the Lamarckian genetic algorithm and the results were analyzed using binding energy. Analysis was based on lowest docked energy and inhibition constant values. Among the tested compounds, 3g, 3a, 3hand 3f derivatives of oxadiazole showed highest binding energy with the lowest inhibition constant. From the observed results it is concluded that 3g, 3a, 3h and 3f showed more affinity to Asp Kinase protein.
STUDY OF MYCOTOXIC EFFECT AND CONTROL OF ASPERGILLUS NIGER INFECTION IN LEGUMINOSAE (FABACEAE) WITH SPECIAL REFERENCE TO ARACHIS HYPOGAEA
Authors: Thakar Angira , Patel Mrunali , Badlawala Ankita , Patel Priti
Published: May 2022

The strain of fungus namely Aspergillus niger was isolated from infected groundnut crop field, collection from Rajasthan Agricultural Research Institute, Durgapura, Jaipur. A number of fungicides were assayed for antifungal efficacy. The fungicides like Carbendazim, Mancozeb, kemoxyl and Antracol were used and they showed different antifungal activity against isolated infectious crop. The treatment of spray and drenching of different fungicide were observed and infected Leguminosae plant was recovered by the effect of fungicide. The best antifungal activity was observed in Antracol fungicide sample. The fungal resistance to Carbendazim has been reported in minor amount, which make it a very useful in preventing fungal infection in Leguminosae plants.
"Generalising and Negotiating Queer Talk: The Selected Plays of Mahesh Dattani"
Authors: Devi Sanjna , Sharma Tanu , Rupa Ms.
Published: May 2022

Mahesh Dattani is an Indian playwright and the most outstanding practitioner of art performing. He is the author who has successfully launched the Indian theatre. In this paper various issues like homosexuality, gender discrimination and commensalism will be of the main focus. There will be an attempt to understand the Indian gay and lesbian problem and how homosexuals have been marginalized in the society.
A Finite Difference Method for Positive Definite Fractional Damped String Vibration Equations
Authors: Wei Congcong , Yin Zhe , Zhu Ailing
Published: May 2022

In this paper, the finite difference method is used to solve the positive fractional derivative damped string vibration equations, and the vibration attenuation phenomenon of the model is described by numerical simulation. In numerical examples, the effects of the order of the positive definite fractional derivative and the damping coefficient on vibration are studied and compared respectively. The results show that, on the one hand, when the damping coefficient c is fixed, the closer the order p(0 < p < 1) is to 1, the faster the attenuation is. On the other hand, when the order p is fixed, the larger the damping coefficient c is, the faster the attenuation is.
HİZMET SEKTÖRÜ İÇİNDE BANKALAR VE BANKACILARIN PAZARLAMA MOTİVASYONLARI ÜZERİNE BİR ARAŞTIRMA
Authors: KALELİ Sumru , YENEKESKİN Refiye Simge
Published: May 2022

Hizmetlerin pazarlanması söz konusu olduğunda, gerek işlem hacmi gerekse diğer sektörlere etkileri bakımından bankalar ayrı bir öneme sahiptir. Diğer hizmet işletmelerinde olduğu gibi bankalarda da, çoğu zaman müşterilerin aldıklarını hizmet ve ürünler, doğrudan ilişki içinde bulundukları çalışanlarla değerlendirilir. Bu sebeple iç müşteriler olarak adlandırılan çalışanların, pazarlama faaliyetlerini gerçekleştirirken sahip oldukları motivasyon ve çalıştıkları kurumların sunduğu hizmetlerin bu motivasyona ne ölçüde katkı sunduğu toplam başarı için son derece önemlidir.

Bu çalışma, Edirne ilinde faaliyet gösteren 15 adet bankanın pazarlama departmanında çalışan 81 bankacı üzerinde yapılan bir araştırmayı içermektedir. Araştırmada, banka çalışanlarının demografik özelliklerine ve çalıştıkları kurumun sermaye yapısına göre, pazarlama motivasyonları ve hizmet tutumlarında bir farklılık olup olmadığı incelenmiştir. Anket yöntemi kullanılmış, verilen cevaplar SPSS programıyla analiz edilmiştir. Çıkan sonuca göre; katılımcıların demografik özelliklerine göre birbirinden farklı tutumlara sahip oldukları ancak çalıştıkları kurumun sermaye yapısına göre farklı bir görüş ve tutum içinde bulunmadıkları saptanmıştır.
Autismo: Modos pedagógicos de alfabetização e letramento
Authors: Trevizan Zizi , Araújo Gisele Silva
Published: May 2022

Esta pesquisa qualitativa envolve Análise Documental de Coleções Didáticas destinadas à alfabetização de alunos com Transtornos do Espectro Autista, produzidas nos anos de 2015 a 2018, período posterior à determinação de Lei de obrigatoriedade de inclusão dos autistas no Sistema Regular de Ensino, em todos os níveis escolares (BRASIL, 2012; 2014). As questões problematizadoras que geraram a Análise Documental foram: Qual o aporte epistemológico utilizado, nestas Coleções, para norteamento dos processos de alfabetização? Ele estaria vinculado à lógica formal da Pedagogia Tradicional? Ou centrado na lógica dialética da Pedagogia Histórico-Cultural e da Pedagogia Histórico-Crítica? Os resultados confirmaram a hipótese inicial do uso único da lógica formal da Pedagogia Tradicional e possibilitaram o alcance do objetivo final da proposição de revisões epistemológicas destas Coleções, para uma formação reflexiva dos autistas, a partir de suas relações intra e inter pessoais, valorizadas pela Psicologia do Desenvolvimento Cultural e pela Filosofia Materialista da Linguagem.
A experiência do estágio supervisionado na EJA no curso de pedagogia da UFAL: As vozes dos estudantes
Authors: Silva Elvson Arlindo da , Silva Gauquilane Júlia da , Silva Givanildo Da
Published: May 2022

O objetivo geral da pesquisa foi compreender a visão dos estudantes do curso de Pedagogia, da Universidade Federal de Alagoas, sobre o estágio supervisionado na EJA. Os objetivos específicos foram perceber o papel do estágio supervisionado na EJA na formação dos estudantes e analisar, a partir da visão dos estudantes, as práticas vivenciadas no estágio supervisionado na EJA no curso de Pedagogia da UFAL. O caminho metodológico da pesquisa esteve pautado em uma abordagem qualitativa e na pesquisa exploratória. Os participantes da pesquisa foram estudantes do curso de Pedagogia, da UFAL, campus A. C. Simões, matriculados nos estágios III e IV, no semestre 2020.2. A coleta de dados foi realizada por meio de questionário on-line. Os dados foram analisados a partir da Análise do Conteúdo. Como resultados, foi possível notar que a práxis pedagógica dos estágios supervisionados esteve baseada na ação-reflexão-ação, reverberando em uma ação significativa para os estagiários.
Analisis Data Sumber Daya Manusia Dalam Isu-Isu Global
Authors: Samad Abdul Wahab
Published: May 2022

Tujuan penelitan ini adalah untuk mengetahui perkembangan penggunaan aplikasi Analisa data pada bidang sumber daya manusia dan tantangan analisis data dalam isu-isu global yang penting pada era industri 4.0  dalam memenuhi kemustahilan mengganti kecerdasan manusia dengan mesin, dengan di dasarkan pada kemampuan mesin dan manusia mengelola data. Metode yang digunakan adalah kualitatif troubling method analisis. Hasilnya menemukan applikasi data Analisa pada era industri 4.0 pada seluruh aspek kecerdasan manusia dapat digantikan oleh robot dengan memori data yang sangat besar.
Pengaruh Pelayanan Fasilitas di Terminal Keberangkatan terhadap Kepuasan Penumpang Selama Pandemi Covid-19 di Bandar Udara Yogyakarta International Airport
Authors: Langgeng Slamet Widodo  , Nuning Agustina Ambarsari
Published: May 2022

Penelitian ini bertujuan untuk untuk mengetahui pelayanan fasilitas di terminal keberangkatan apakah berpengaruh atau tidak terhadap kepuasan penumpang selama pandemi Covid–19 di Bandar Udara Yogyakarta International Airport. Jenis penelitian ini adalah kuantitatif dengan pendekatan deskriptif. Pengambilan sampel sebanyak 99 responden, teknik pengumpulan data melalui penyebaran angket/kuesioner dan dokumentasi. Analisis data dan pengujian hipotesis dilakukan dengan menggunakan simple linear regression analysis (analisis regresi linear sederhana) melalui SPSS for windows release 25.0. Hasil penelitian menunjukkan bahwa pelayanan fasilitas di terminal keberangkatan berpengaruh positif dan signifikan terhadap kepuasan penumpang selama pandemi Covid–19 di Bandar Udara Yogyakarta International Airport.
Accounting Information System Analysis of Internal Control of UPT Income Karangbinangun Lamongan Health Center
Authors: Erry Setiawan  , Dwi Dewianawati  , Frendy Sutikno  , Eny Nuraeni
Published: May 2022

The purpose of this study was to determine the analysis of accounting information control system of internal. Based on the measurement scale Gutman, accounting information system of the internal control values ​​obtained revenues amounting to 85.71%. This value is compared with the measurement criteria of accounting information systems with the scale Gutman including a sufficient criterion. The role of information systems in the UPT Puskesmas akuntani Karangbinangun been done  adequately. Inadequate system of accounting information obtained can be identified that the management of the elements of accounting information system, the purpose of accounting information system, and the function of accounting information system has run as much as possible. So as to provide pengolalaan adequate accounting information system. Accounting information systems to work toward internal control at revenue has been done adequately. Internal control plans and methods of income is against (the elements of accounting information systems, the purpose of accounting information systems, and accounting information systems function) conducted by the internal to control income derived from activities done in a period, which will produce reliable financial statements concerning effective and efficient revenue. The results of this study, for accounting information systems at  implementation should be further improved so that easier to carry out daily operations ranging from data collection, classification of data, data storage, and surveillance data to health centers can provide a more adequate control to keep the health center assets. So that the internal control income must remain in place and be effected again, so that the financial statements more valid, effective and efficient.
Comparison of wind flow effect for varying cross – sectional height of tall building using ANSYS
Authors: Rukhaiyar Ark , Jayant Bhagya , Dahiya Kunal , Raj Ritu
Published: May 2022

Study of wind is empirical for the designing of tall structures because it considers the instability due to slender behavior of these structures. In this study, three models namely A, B, and C are analyzed on ANSYS using Computational fluid dynamics approach. These three models have a total height of 192 m built of two types of cross – sections as plus and square (below plus). These models differ by the heights of the cross sections only. Plus and square cross – section heights for Model A are 96 m each, for Model B are 48 m and 144 m respectively and for Model C are 144 m and 48 m respectively. CFD simulations are performed for wind of magnitude 10 m/s when incident on these three modes at wind incidence angle 0° and the results are interpreted in terms of pressure contours and streamlines. It is observed that designing for critical faces is a must. Also from streamlines it may be observed that as the cross – sectional height of irregular shape increase, more stability is noticed. It is also observed that the wind velocity increases at the top most points of the models.
Identifikasi Tumbuhan Berbiji (Spermatophyta) di Taman Botani Sukorambi Kabupaten Jember untuk Menunjang Mata Kuliah Taksonomi Tumbuhan
Authors: Azisah Fita Elisia , Sudiarti Diah , Hasbiyati Haning
Published: May 2022

Sukorambi Botanical Garden is a natural tourist spot for flora and fauna with a land area of ​​about 12 hectares. In this location, there are about 500 types of plants ranging from lower-grade plants to higher-grade plants. The existence of seed plants (Spermatophyta) of habitus tree in the Botanical Garden has been identified, but there are some plants whose species are not yet known. This research is a descriptive study with a qualitative approach. The method used in this research is a survey method. The research data were analyzed descriptively and identified to the genus level. The results showed that there were 66 genera of seed plants (Spermatophyta) belonging to 30 families. These families are Achariaceae, Anarcadiacea, Annonaceae, Apocynaceae, Araucariaceae, Arecaceae, Bignoniaceae, Burseraceae, Clusiaceae, Ebenaceae, Fabaceae, Gnetaceae, Lamiaceae, Lauraceae, Lythraceae, Malvaceae, Meliaceae, Mimosaceae, Moraceae, Moringaceae, Myristicaceae, Oxalidaceae, Rutaceae, Sapindaceae, Sapotaceae, and Thymelaeaceae. The results of identification can be used as a learning resource to support the Plant Taxonomy course.
Sarcomatoid Change in Adenocarcinoma Arising in Adulthood Congenital Pulmonary Airway Malformation
Authors: Tassi Valentina , Daddi Niccolò , Altimari Annalisa , Gruppioni Elisa , Crinò Lucio , Rossi Giulio , Mattioli Sandro
Published: May 2022

Congenital pulmonary airway malformations (CPAM) are rare conditions generally diagnosed in childhood and possibly harboring malignant tumor growths. We describe a unique case of pleomorphic carcinoma in a longstanding type 1 CPAM diagnosed by wedge resection. The patient underwent completion left lower lobectomy and lymphadenectomy, but cancer recurred in nodal station #7 six months later. Clinicians should keep in mind that CPAM may hide radiologically undetectable malignancy in a relevant rate of cases, then requiring surgery in all patients. While MIA is the most common histology in type 1 CPAM, sarcomatoid change has herein been demonstrated.
Influence of Age on Adherence to Auto-CPAP: Experience from a Sleep Center in Portugal
Authors: Barroso Andreia , Carrondo Maria Cristina , Moita Joaquim
Published: May 2022

Introduction: Obstructive sleep apnea (OSA) is a disorder characterized by obstructive apneas, hypopneas, and/or arousals related to respiratory effort caused by repetitive collapse of the upper airway during sleep. Left untreated, or with poor adherence to treatment, is likely to lead to negative outcomes, especially cardiac or cerebrovascular diseases. Our objective was to investigate age as a potential factor that may interfere with adherence to treatment with automatic positive airway pressure (APAP). Materials and Methods: This is a cross-sectional study on 1151 patients with OSA and we analyzed the adherence data of all patients who had been on APAP for at least six months during the period from 1 July 2019 to 31 December 2020 at Centro de Medicina do Sono. Spearman correlation was used in the bivariate analysis and to determine the factors associated with APAP adherence, a logistic regression was performed. Results: Of 1151 patients included, 780 patients were men (67.1%) and the majority was under 65 years (59.4%). APAP adherence was higher in older age groups (p < 0.001) and in patients with a higher AHI (p < 0.001), no differences were observed with regards to gender. In the multivariable regression analysis, the main factors associated with adherence were age group over 65 years (OR = 2.435; 95% CI = 1.862–3.185), AHI 15–30/h (OR = 1.733; 95% CI = 1.242–2.416), and AHI > 30/h (OR = 3.406; 95% CI = 2.426–4.782). Conclusions: Patients older than 65 years have better adherence to APAP than younger ones and with moderate but especially severe AHI have better adherence than those with the milder form of the disease.
Should a Prescription Database Be Used to Search Uncontrolled Severe Asthmatics?
Authors: Sposato Bruno , Petrucci Elisa , Lena Fabio , Lacerenza Leonardo Gianluca , Bindi Michele , Montagnani Andrea , Perrella Antonio , Scalese Marco
Published: May 2022

Introduction: Many uncontrolled severe asthmatics are not on biologic therapy. We hypothesized that using a prescription database could help us identify them. Material and Methods: 3309 patients who received at least one Montelukast prescription in 2019 were extracted from our prescription database. Number of packages/year, types and dosages of ICS, LABA, ICS/LABA, LAMA and monoclonal antibodies were considered for each patient. In our analysis, for subjects that took > 7 packages of ICS/LABA + LTRA +/– LAMA (high adherent) the number of oral corticosteroids (OC) packets prescribed for each of them was also looked upon. Results: Patients that took ICS/LABA or ICS/LABA + LAMA continuously with high ICS doses were 188 (25.6%) and 117 (39.3%) respectively (total: 305 — 29.5%). Among them, 58 (30.9%) and 53 (45.3%) (total: 111 — 36.4%) were prescribed more than 2 OC packages. Whereas, 21 (11.2%) and 24 (20.5%) patients (total: 45 — 14.75%) received at least 4 OC package prescriptions. Conclusion: Approximately 36% of patients in continuous step-4/5 of GINA Guideliness treatment may have severe uncontrolled asthma (overusing OC) which needed biologic treatment. In our opinion, a prescription archiving database may be a tool that can help us identify such uncontrolled asthma patients.
Monitoring Organising Pneumonia Pattern in CT among Mild COVID-19: Unclear Clinical Utility
Authors: Sakthivel Pirabu , Ish Pranav
Published: May 2022

We read with interest the recent article published by Raoufi et al [...]
Prognostic Role of Cardiopulmonary Exercise Testing in Pulmonary Hypertension: A Systematic Review and Meta-Analysis
Authors: Barbagelata Leandro , Masson Walter , Bluro Ignacio , Lobo Martín , Iglesias Diego , Molinero Graciela
Published: May 2022

Introduction: Several studies have evaluated the relation between variables of cardiopulmonary exercise testing (CPET) and major clinical events in pulmonary hypertension (PH) patients, although the results were conflicting. The main objective of this study was to investigate the prognostic value of the CPET derived parameters on all-cause mortality or urgent transplantation in PH patients. Material and Methods: A meta-analysis of time-to-event outcomes were performed from observational studies that evaluated the predictive value of CEPT-related variables [peak oxygen uptake (VO₂) and the ventilation to CO₂ production slope (VE/VCO₂)] in PH patients, reporting data from mortality or urgent transplantation, after searching the PubMed/MEDLINE, Embase, Science Direct, Scopus, Google Scholar, and Cochrane databases. A random-effects meta-analysis model was then applied. Results: Nine eligible studies, including 986 patients, were identified and considered eligible for the quantitative analyses. This meta-analysis showed that high peak VO₂ was associated with a lower mortality or transplant occurrence (HR: 0.81; 95% CI: 0.78–0.85, I2 = 29%). In addition, high VE/VCO₂ slope was associated with a higher incidence of the primary endpoint (HR: 1.04; 95% CI: 1.02-1.06, I2 = 78%). The sensitivity analysis showed that the results were robust. Conclusions: Our data suggest that in a population with PH the CPET-related variables have predictive capacity regarding mortality and the risk of transplantation. Future studies should establish the best cut-off points for these CPET-related variables.
A Study on Fathers’ Experiences of Participation in Parents’ Movement for People with Disabilities
Authors: Heo Joon , Lee Soojeoung
Published: May 2022

Joon Heo, Soojeoung Lee
Kampung Taman’s Corridor Structure Investigation: A Territorial Analysis by Using a Snapshot Method
Authors: Lianto Fermanto , Trisno Rudy , Husin Denny , Tedyardi Clinton
Published: May 2022

Communality is prime in kampungs; the phenomenon of collective activities in kampungs is reflected in their structure, especially in the network of corridors, i.e., the in-between spaces that are the topic of this research. This research explored territorial analysis by converting photographs into architectural mapping diagrams and photo-collages using the snapshot method. The diagrams were produced to highlight the collective structure and the actual processes of communality. The physical structure was investigated as a medium to accommodate everyday activities in Kampung Taman, Yogyakarta, presenting a territorial analysis with respect to: a) implementation/execution, including activities, expressions, spaces, and joint structures; b) circulation; and c) dynamic phenomena occurring in Kampung Taman. The investigation illustrates a territorial implementation involving the physical structure of Kampung Taman’s corridor network and the user’s interpretation of space when conducting communal activities. This involves sharing social, communal, and public spaces. The territorial activities that affect the Kampung’s physical structure were tracked. The novelty is the discovery of spatial patterns that suggest organic development of the corridor network, as illustrated by a compilation of diagrams composed of strong examples captured directly on-site from Augustus 2018 to November 2020.
Ungleichheiten der Lebensverhältnisse zwischen Stadt und Land
Authors: ELTGES MARKUS , MILBERT ANTONIA
Published: May 2022

Wohnen endet nicht an der Wohnungstür. Wohnqualität hängt auch von den regionalen Lebensbedingungen ab. Deshalb werden in diesem Beitrag die unterschiedlichen Lebensverhältnisse in Stadt und Land sowie in West und Ost untersucht. Zusätzlich wird aber auch danach gefragt, wie sich die Lebensverhältnisse in Abwanderungsregionen von denen in Regionen mit Bevölkerungsgewinnen unterscheiden, denn die demografische Entwicklung ist nach wie vor Ursache und einer der wichtigsten Treiber für die räumlichen Differenzierungen der Lebensverhältnisse. Die Komponenten der demografischen Entwicklung – Außenwanderung, Binnenwanderung und natürliche Bevölkerungsbewegungen – werden zuerst zwischen Ost- und Westdeutschland, Stadt und Land sowie den eigens dafür gebildeten Demografietypen analysiert. Sodann folgt die Betrachtung von räumlichen Unterschieden der Bevölkerung hinsichtlich Alters- und Sozialstruktur, der Entwicklung der Arbeitsplätze, Wohnen und Daseinsvorsorge. Die Bundesregierungen der 19. und 20. Legislaturperiode betonen die Bedeutung gleichwertiger Lebensverhältnisse und zielen auf den Abbau politisch nicht akzeptierter Ungleichheiten. Diese Aufgabe erfordert eine Koordination und Abstimmung der Fachpolitiken und der Landes- und Kommunalpolitiken unter Einbeziehung der Unternehmen und Sozialpartner.
Insecticide Resistance in WhitefliesBemisia tabaci(Gennadius): Current Global Status
Authors: Patra Biswajit , Kumar Hath Tapan
Published: May 2022

The whitefly, Bemisia tabaci (Gennadius) is a polyphagous pest causing considerable yield loss to many crops around the globe. It is a phloem feeder and transmits several viral diseases as well. It has great genetic diversity and is considered a complex of biotypes. Despite the adoption of several available control strategies, management by chemical pesticides has still been the first choice for the farmers to protect their crops. However, prolonged use of chemical pesticides has ultimately accelerated the development of multifold resistance against various groups of insecticides in different parts of the world. The status of development of insecticide resistance against different groups of insecticides by this pest, mechanisms of resistance, cross-resistance, role of detoxifying enzymes, and management issues have been discussed in this chapter.
Characterization and Integration of Muscle Signals for the Control of an Exoskeleton of the Lower Limbs during Locomotor Activities
Authors: Charafeddine Jinan , Alfayad Samer , Olaru Adrian , Dychus Eric
Published: May 2022

Daily activities are a source of fatigue and stress for people with lower extremity spasticity. The possible aids must be introduced while maintaining priority control by the patient. This work aims to develop such an application in the context of walking on the exoskeleton developed at the Systems Engineering Laboratory of Versailles (LISV). The application results are based on data recorded at the END-ICAP laboratory with gait sensors for healthy subjects, people with CPs, and people who had a stroke. Our contribution is the proposal of a new method of neuromotor control for a rehabilitative exoskeleton. It consists in determining and assisting the motor instructions for the movements of a patient while retaining his expertise; the assistance as needed and the detection of its intention based on a fusion of information. The results show that the proposed index characterizes the relationship of the angle difference with a reference movement for each joint. It dynamically compensates for movements efficiently and safely. This index is applicable for gait pathology studies and robotic gait assistance.
Nonribosomal Peptide Synthesis
Authors: Dincer Sadık , Aysun Mercimek Takci Hatice , Sumengen Ozdenefe Melis
Published: May 2022

Nonribosomal peptides (NRPs) are a type of secondary metabolite with a wide range of pharmacological and biological activities including cytostatics, immunosuppressants or anticancer agents, antibiotics, pigments, siderophores, toxins. NRPs, unlike other proteins, are synthesized on huge nonribosomal peptide synthetase (NRPS) enzyme complexes that are not dependent on ribosomal machinery. Bacteria and fungi are the most common NRPs producers. Furthermore, the presence of these peptides has been confirmed in marine microbes. Nowadays, many of these peptides are used in the treatments of inflammatory, cancer, neurodegenerative disorders, and infectious disease for the development of new therapeutic agents. The structure, function, and synthesis of NRPs, as well as producer microorganisms and their several application areas, are covered in this chapter.
Pasado, presente y futuro de la traducción de literatura infantil y juvenil
Authors: Valero Cuadra Pino , Marcelo Wirnitzer Gisela , Pérez Vicente Nuria
Published: May 2022

La diversidad de tipologías textuales y las dificultades y problemas que se le presentan al traductor han contribuido a diversificar constantemente los Estudios de Traducción. En el caso de la traducción de literatura infantil y juvenil (LIJ), sumamos a estos factores el complejo entramado que constituye este sistema literario, y el resultado de la ecuación se refleja en la gran variedad de inquietudes investigadoras actuales en el ámbito de la traducción de la LIJ. No olvidemos que la escritura para niños se ha erigido en una fuente inagotable de creatividad, de formatos y de géneros, y esta inventiva, a la hora de trasladarla a otras lenguas y otras culturas, supone verdaderos retos para los traductores. Por estas razones, en este artículo hacemos un recorrido bibliográfico cronológico y temático de este ´mbito investigador, periférico, pero tan complejo y actual a la vez: el de la traducción de la literatura infantil y juvenil.
The Future’s Overrated: How History and Ahistoricity Collide in William Gibson’s Bridge Trilogy
Authors: Hayes Lil
Published: May 2022

In 1988, Gibson “asserted his interest in the how’s and why’s of memory, the ways it defines who and what we are, in how easily it’s subject to revision” (qtd. in McCaffery 224). While this statement is a reflection on his appropriation of human memory in the Sprawl trilogy, it is also a useful standpoint from which to assess the interplay between history and memory
in the Bridge trilogy. In my view, this trilogy is primarily concerned with the implications of postmodernization for historical perception. Moreover, it serves to explore how the proliferation of the spectacle has significant effects on social memory, the ramification of which is the eventual effacement of memory’s value, and its substitution by commodified images. Through a close assessment of Gibson’s architecturally familiar landscape and the perseverance of nostalgia in an ahistorical society, I argue that in this postmodern world, history as a concept is not obsolete despite the death of historical perspective that postmodernism ideologically affirms. In fact, by creating a world that simultaneously experiences the “abandonment of history” and the “false consciousness of time” (Debord 90), Gibson is able to convey the idea that historical perspective, no matter how unreliable, is the only means through which to fully understand not only the past, but also the present, and, indeed, the future.
Where Futures Converge
Authors: Buderi Robert
Published: May 2022

The evolution of the most innovative square mile on the planet: the endless cycles of change and reinvention that created today's Kendall Square.

Kendall Square in Cambridge, Massachusetts, has been called “the most innovative square mile on the planet.” It's a life science hub, hosting Biogen, Moderna, Pfizer, Takeda, and others. It's a major tech center, with Google, Microsoft, IBM, Amazon, Facebook, and Apple all occupying big chunks of pricey office space. Kendall Square also boasts a dense concentration of startups, with leading venture capital firms conveniently located nearby. And of course, MIT is just down the block. In Where Futures Converge, Robert Buderi offers the first detailed account of the unique ecosystem that is Kendall Square, chronicling the endless cycles of change and reinvention that have driven its evolution.

Buderi, who himself has worked in Kendall Square for the past twenty years, tells fascinating stories of great innovators and their innovations that stretch back two centuries. Before biotech and artificial intelligence, there was railroad car innovation, the first long-distance telephone call, the Polaroid camera, MIT's once secret, now famous Radiation Laboratory, and much more. Buderi takes readers on a walking tour of the square and talks to dozens of innovators, entrepreneurs, urban planners, historians, and others. He considers Kendall Square's limitations—it's “gentrification gone rogue,” by one description, with little affordable housing, no pharmacy, and a scarce middle class—and its strengths: the “human collisions” that spur innovation.

What's next for Kendall Square? Buderi speculates about the next big innovative enterprises and outlines lessons for aspiring innovation districts. More important, he asks how Kendall Square can be both an innovation hub and a diversity, equity, and inclusion hub. There's a lot of work still to do.
Thermosynechococcus switches the direction of phototaxis by a c-di-GMP-dependent process with high spatial resolution
Authors: Nakane Daisuke , Enomoto Gen , Bähre Heike , Hirose Yuu , Wilde Annegret , Nishizaka Takayuki
Published: May 2022

Many cyanobacteria, which use light as an energy source via photosynthesis, show directional movement towards or away from a light source. However, the molecular and cell biological mechanisms for switching the direction of movement remain unclear. Here, we visualized type IV pilus-dependent cell movement in the rod-shaped thermophilic cyanobacterium Thermosynechococcus vulcanus using optical microscopy at physiological temperature and light conditions. Positive and negative phototaxis were controlled on a short time scale of 1 min. The cells smoothly moved over solid surfaces towards green light, but the direction was switched to backward movement when we applied additional blue light illumination. The switching was mediated by three photoreceptors, SesA, SesB, and SesC, which have cyanobacteriochrome photosensory domains and synthesis/degradation activity of the bacterial second messenger cyclic dimeric GMP (c-di-GMP). Our results suggest that the decision-making process for directional switching in phototaxis involves light-dependent changes in the cellular concentration of c-di-GMP. Direct visualization of type IV pilus filaments revealed that rod-shaped cells can move perpendicular to the light vector, indicating that the polarity can be controlled not only by pole-to-pole regulation but also within-a-pole regulation. This study provides insights into previously undescribed rapid bacterial polarity regulation via second messenger signalling with high spatial resolution.
Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis
Authors: Rodríguez-Lorenzo Sabela , van Olst Lynn , Rodriguez-Mogeda Carla , Kamermans Alwin , van der Pol Susanne MA , Rodríguez Ernesto , Kooij Gijs , de Vries Helga E
Published: May 2022

Multiple sclerosis (MS) is a chronic demyelinating disease characterised by immune cell infiltration resulting in lesions that preferentially affect periventricular areas of the brain. Despite research efforts to define the role of various immune cells in MS pathogenesis, the focus has been on a few immune cell populations while full-spectrum analysis, encompassing others such as natural killer (NK) cells, has not been performed. Here, we used single-cell mass cytometry (CyTOF) to profile the immune landscape of brain periventricular areas – septum and choroid plexus – and of the circulation from donors with MS, dementia and controls without neurological disease. Using a 37-marker panel, we revealed the infiltration of T cells and antibody-secreting cells in periventricular brain regions and identified a novel NK cell signature specific to MS. CD56bright NK cells were accumulated in the septum of MS donors and displayed an activated and migratory phenotype, similar to that of CD56bright NK cells in the circulation. We validated this signature by multiplex immunohistochemistry and found that the number of NK cells with high expression of granzyme K, typical of the CD56bright subset, was increased in both periventricular lesions and the choroid plexus of donors with MS. Together, our multi-tissue single-cell data shows that CD56bright NK cells accumulate in the periventricular brain regions of MS patients, bringing NK cells back to the spotlight of MS pathology.
Hyperreactivity to uncertainty is a key feature of subjective cognitive impairment
Authors: Attaallah Bahaaeddin , Petitet Pierre , Slavkova Elista , Turner Vicky , Saleh Youssuf , Manohar Sanjay G , Husain Masud
Published: May 2022

With an increasingly ageing global population, more people are presenting with concerns about their cognitive function, but not all have an underlying neurodegenerative diagnosis. Subjective cognitive impairment (SCI) is a common condition describing self-reported deficits in cognition without objective evidence of cognitive impairment. Many individuals with SCI suffer from depression and anxiety, which have been hypothesised to account for their cognitive complaints. Despite this association between SCI and affective features, the cognitive and brain mechanisms underlying SCI are poorly understood. Here, we show that people with SCI are hyperreactive to uncertainty and that this might be a key mechanism accounting for their affective burden. Twenty-seven individuals with SCI performed an information sampling task, where they could actively gather information prior to decisions. Across different conditions, SCI participants sampled faster and obtained more information than matched controls to resolve uncertainty. Remarkably, despite their ‘urgent’ sampling behaviour, SCI participants were able to maintain their efficiency. Hyperreactivity to uncertainty indexed by this sampling behaviour correlated with the severity of affective burden including depression and anxiety. Analysis of MRI resting functional connectivity revealed that SCI participants had stronger insular-hippocampal connectivity compared to controls, which also correlated with faster sampling. These results suggest that altered uncertainty processing is a key mechanism underlying the psycho-cognitive manifestations in SCI and implicate a specific brain network target for future treatment.
Single-cell monitoring of dry mass and dry mass density reveals exocytosis of cellular dry contents in mitosis
Authors: Miettinen Teemu P , Ly Kevin S , Lam Alice , Manalis Scott R
Published: May 2022

Cell mass and composition change with cell cycle progression. Our previous work characterized buoyant mass dynamics in mitosis (Miettinen et al., 2019), but how dry mass and cell composition change in mitosis has remained unclear. To better understand mitotic cell growth and compositional changes, we develop a single-cell approach for monitoring dry mass and the density of that dry mass every ~75 s with 1.3% and 0.3% measurement precision, respectively. We find that suspension grown mammalian cells lose dry mass and increase dry mass density following mitotic entry. These changes display large, non-genetic cell-to-cell variability, and the changes are reversed at metaphase-anaphase transition, after which dry mass continues accumulating. The change in dry mass density causes buoyant and dry mass to differ specifically in early mitosis, thus reconciling existing literature on mitotic cell growth. Mechanistically, cells in early mitosis increase lysosomal exocytosis, and inhibition of lysosomal exocytosis decreases the dry mass loss and dry mass density increase in mitosis. Overall, our work provides a new approach for monitoring single-cell dry mass and dry mass density, and reveals that mitosis is coupled to extensive exocytosis-mediated secretion of cellular contents.