bluuebunny/crossref_metadata_2025 huggingface dataset:
Possible Mechanisms for Adverse Cardiac Events Caused by Exercise-Induced Hypertension in Long-Distance Middle-Aged Runners: A Review
Authors: Kim Young-Joo , Park Kyoung-Min
Published: April 2024

Sudden cardiac death (SCD) is rare among athletes. However, hypertrophic cardiomyopathy is the leading cause of SCD among those <35 years of age. Meanwhile, coronary artery disease (CAD) is the primary SCD cause among those ≥35 years of age. CAD-induced plaque ruptures are believed to be a significant cause of cardiovascular diseases in middle-aged individuals who participate in extreme long-distance running activities such as marathons. A total of 1970 articles related to EIH were identified using search terms. Out of these, 1946 studies were excluded for reasons such as arterial hypertension, exercise-induced pulmonary hypertension, the absence of exercise stress testing (EST), and a lack of relevance to EIH. The study analyzed 24 studies related to both long-distance runners with exercise-induced hypertension (EIH) and the general public. Among these, 11 studies were quasi-experimentally designed studies used in randomized controlled trials (RCTs) on long-distance runners with EIH. Additionally, 12 studies utilized cohort designs, and one study with a quasi-experimental design was conducted among the general population. Recent studies suggest that an imbalance between oxygen demand and supply due to ventricular hypertrophy may be the actual cause of cardiovascular disease, regardless of CAD. Exercising excessively over an extended period can reduce endothelial function and increase arterial stiffness, which in turn increases afterload and leads to an excessive increase in blood pressure during exercise. Exercise-induced hypertension (EIH), which increases the morbidity rate of resting hypertension and is a risk factor for cardio-cerebro-vascular diseases, is more prevalent in middle-aged long-distance runners than in runners from other age groups, and it increases the prevalence of critical arrhythmias, such as atrial fibrillation or ventricular arrhythmias. EIH is associated with angiotensin II activity, and angiotensin II receptor blockers show promising effects in middle-aged runners. Further, guidelines for preventing excessive participation in races and restricting exercise intensity and frequency would be useful. This review identifies EIH as a potential risk factor for cardiovascular diseases and describes how EIH induces SCD.
Role of Flex-Dose Delivery Program in Patients Affected by HCC: Advantages in Management of Tare in Our Experience
Authors: Paladini Andrea , Spinetta Marco , Matheoud Roberta , D’Alessio Andrea , Sassone Miriana , Di Fiore Riccardo , Coda Carolina , Carriero Serena , Biondetti Pierpaolo , Laganà Domenico , Minici Roberto , Semeraro Vittorio , Sacchetti Gian Mauro , Carrafiello Gianpaolo , Guzzardi Giuseppe
Published: April 2024

Background: Introduced in the latest BCLC 2022, endovascular trans-arterial radioembolization (TARE) has an important role in the treatment of unresectable hepatocellular carcinoma (HCC) as a “bridge” or “downstaging” of disease. The evolution of TARE technology allows a more flexible and personalized target treatment, based on the anatomy and vascular characteristics of each HCC. The flex-dose delivery program is part of this perspective, which allows us to adjust the dose and its radio-embolizing power in relation to the size and type of cancer and to split the therapeutic dose of Y90 in different injections (split-bolus). Methods: From January 2020 to January 2022, we enrolled 19 patients affected by unresectable HCC and candidates for TARE treatment. Thirteen patients completed the treatment following the flex-dose delivery program. Response to treatment was assessed using the mRECIST criteria with CT performed 6 and 9 months after treatment. Two patients did not complete the radiological follow-up and were not included in this retrospective study. The final cohort of this study counts eleven patients. Results: According to mRECIST criteria, six months of follow-up were reported: five cases of complete response (CR, 45.4% of cases), four cases of partial response (PR, 36.4%), and two cases of progression disease (PD, 18.2%). Nine months follow-up reported five cases of complete response (CR, 45.4%), two cases of partial response (PR, 18.2%), and four cases of progression disease (PD, 36.4%). No intra and post-operative complications were described. The average absorbed doses to the hepatic lesion and to the healthy liver tissue were 319 Gy (range 133–447 Gy) and 9.5 Gy (range 2–19 Gy), respectively. Conclusions: The flex-dose delivery program represents a therapeutic protocol capable of “saving” portions of healthy liver parenchyma by designing a “custom-made” treatment for the patient.
A Unique Case of a Gigantic Left Ventricular Myxoma Resulting in Embolic Acute Lower Limb Ischemia in a Pediatric Patient
Authors: Margarint Irina , Sorescu Adelina , Popescu Monica , Robu Mircea , Untaru Olga , Filip Cristina
Published: April 2024

Background: The presence of a primary cardiac tumor in a pediatric patient is a rare echocardiographic finding. Case Report: We report the case of an 11-year-old female patient with multiple peripheral embolisms, due to a gigantic left ventricular tumor, with a unique echocardiographic appearance. The patient was referred to the emergency department due to acute pain and loss of sensitivity in both of her legs. Past medical history was significant for acute lymphoblastic leukemia. Upon physical examination, suspicion of bilateral lower leg ischemia was raised. Doppler arterial ultrasound of both legs confirmed the suspicion mentioned above, as the right lower extremity suffered from partial arterial occlusion of the external iliac artery and total occlusion of the femoral arteries. Meanwhile, in the left lower extremity, the occlusion was localized in the proximal tibio-peroneal artery. Cardiac sonography revealed a massive, mobile, left ventricular intracavitary mass. Aside from its large dimensions (6.3 cm by 3 cm), its aspect was striking as well as it had very mobile and friable edges. Emergency bilateral endarterectomy and excision of the left ventricular tumor were performed alongside systemic anticoagulant therapy, with excellent results, as no tumoral residual masses could be seen in the left ventricle, and the arterial blood flow was restored completely in both lower extremities. The histopathological aspect of the excised masses was that of a myxoma. The patient recovered well after surgery and was discharged on postoperative day 14. Conclusion: Despite only a handful of cases of cardiac myxomas being reported due to their rarity in the pediatric population, clinical presentation with peripheric embolism triggered a high index of suspicion of embolic mechanism in our patient and prompted a rapid assessment and successful management.
Psychiatric Manifestations in Children and Adolescents with Inherited Metabolic Diseases
Authors: Baglioni Valentina , Bozza Fabiola , Lentini Giuliana , Beatrice Annachiara , Cameli Noemi , Colacino Cinnante Elisa Maria , Terrinoni Arianna , Nardecchia Francesca , Pisani Francesco
Published: April 2024

Background: Inherited metabolic disorders (IEMs) can be represented in children and adolescents by psychiatric disorders. The early diagnosis of IEMs is crucial for clinical outcome and treatment. The aim of this review is to analyze the most recurrent and specific psychiatric features related to IEMs in pediatrics, based on the onset type and psychiatric phenotypes. Methods: Following the PRISMA Statement, a systematic literature review was performed using a predefined algorithm to find suitable publications in scientific databases of interest. After removing duplicates and screening titles and abstracts, suitable papers were analyzed and screened for inclusion and exclusion criteria. Finally, the data of interest were retrieved from the remaining articles. Results: The results of this study are reported by type of symptoms onset (acute and chronic) and by possible psychiatric features related to IEMs. Psychiatric phenomenology has been grouped into five main clinical manifestations: mood and anxiety disorders; schizophrenia-spectrum disorders; catatonia; eating disorders; and self-injurious behaviors. Conclusions: The inclusion of a variety of psychiatric manifestations in children and adolescents with different IEMs is a key strength of this study, which allowed us to explore the facets of seemingly different disorders in depth, avoiding possible misdiagnoses, with the related delay of early and appropriate treatments.
Isthmocele and Infertility
Authors: Baldini Giorgio Maria , Lot Dario , Malvasi Antonio , Di Nanni Doriana , Laganà Antonio Simone , Angelucci Cecilia , Tinelli Andrea , Baldini Domenico , Trojano Giuseppe
Published: April 2024

Isthmocele is a gynecological condition characterized by a disruption in the uterine scar, often associated with prior cesarean sections. This anatomical anomaly can be attributed to inadequate or insufficient healing of the uterine wall following a cesarean incision. It appears that isthmocele may impact a woman’s quality of life as well as her reproductive capacity. The incidence of isthmocele can range from 20% to 70% in women who have undergone a cesarean section. This review aims to sum up the current knowledge about the effect of isthmocele on fertility and the possible therapeutic strategies to achieve pregnancy. However, currently, there is not sufficiently robust evidence to indicate the need for surgical correction in all asymptomatic patients seeking fertility. In cases where surgical correction of isthmocele is deemed necessary, it is advisable to evaluate residual myometrial thickness (RMT). For patients with RMT >2.5–3 mm, hysteroscopy appears to be the technique of choice. In cases where the residual tissue is lower, recourse to laparotomic, laparoscopic, or vaginal approaches is warranted.
Safe and Informed Use of Gadolinium-Based Contrast Agent in Body Magnetic Resonance Imaging: Where We Were and Where We Are
Authors: Iacobellis Francesca , Di Serafino Marco , Russo Camilla , Ronza Roberto , Caruso Martina , Dell’Aversano Orabona Giuseppina , Camillo Costanza , Sabatino Vittorio , Grimaldi Dario , Rinaldo Chiara , Barbuto Luigi , Verde Francesco , Giacobbe Giuliana , Schillirò Maria Laura , Scarano Enrico , Romano Luigia
Published: April 2024

Gadolinium-based contrast agents (GBCAs) have helped to improve the role of magnetic resonance imaging (MRI) for the diagnosis and treatment of diseases. There are currently nine different commercially available gadolinium-based contrast agents (GBCAs) that can be used for body MRI cases, and which are classifiable according to their structures (cyclic or linear) or biodistribution (extracellular-space agents, target/specific-agents, and blood-pool agents). The aim of this review is to illustrate the commercially available MRI contrast agents, their effect on imaging, and adverse reaction on the body, with the goal to lead to their proper selection in different clinical contexts. When we have to choose between the different GBCAs, we have to consider several factors: (1) safety and clinical impact; (2) biodistribution and diagnostic application; (3) higher relaxivity and better lesion detection; (4) higher stability and lower tissue deposit; (5) gadolinium dose/concentration and lower volume injection; (6) pulse sequences and protocol optimization; (7) higher contrast-to-noise ratio at 3.0 T than at 1.5 T. Knowing the patient’s clinical information, the relevant GBCAs properties and their effect on body MRI sequences are the key features to perform efficient and high-quality MRI examination.
Long-Term Results of the Mini Maze Standalone Bi-Atrial Surgical Ablation: A 10-Year Follow-Up
Authors: Radauskaite Greta , Rackauskas Gediminas , Danilenko Svetlana , Janusauskas Vilius , Aidietis Audrius
Published: April 2024

Background: One way to treat atrial fibrillation is through surgical ablation. However, the literature only provides information on patient follow-up results for up to 5 years. Methods: In order to assess long-term monitoring data over ten years, this retrospective study included 58 patients with paroxysmal or persistent atrial fibrillation who underwent Mini Maze surgical ablation at Santaros Clinics between 1 February 2009 and 1 June 2014. The follow-up time after surgery was 144 ± 48 months. We evaluated the absence of atrial fibrillation, echocardiographic and clinical parameters, and EHRA score. Results: Sinus rhythm remained in 69.4%, 75.5%, 55.6%, and 44.1% of patients with paroxysmal AF, and 68,2%, 59.1%, 50%, and 41.9% of patients with persistent AF (p = 0.681). In the post-operative period, one patient (1.7%) had a transient ischemic attack, and another patient (1.7%) had a thoracotomy for post-operative bleeding. A total of 20% of patients were diagnosed with a post-operative respiratory tract infection. EHRA scores showed that patients’ quality of life improved after they underwent Mini Maze surgical ablation. Conclusions: Despite AF recurrences after surgery, quality of life remains better than before surgery, showing that Mini Maze surgery is an effective and safe second-line treatment method for atrial fibrillation.
Asymptotic Ray Method for the Double Square Root Equation
Authors: Shilov Nikolay N. , Duchkov Anton A.
Published: April 2024

The parabolic wave equation describes wave propagation in a preferable direction, which is usually horizontal in underwater acoustics and vertical in seismic applications. For dense receiver arrays (receiver spacing is less than signal wavelength), this equation can be used for propagating the recorded wavefield back into the medium for imaging sources and scattering objects. Similarly, for multiple source and receiver array acquisition, typical for seismic exploration and potentially beneficial for ocean acoustics, one can model data in one run using an extension of the parabolic equation—the pseudo-differential Double Square Root (DSR) equation. This extended equation allows for the modeling and imaging of multi-source data but operates in higher-dimensional space (source, receiver coordinates, and time), which makes its numerical computation time-consuming. In this paper, we apply a faster ray method for solving the DSR equation. We develop algorithms for both kinematic and dynamic ray tracing applicable to either data modeling or true-amplitude recovery. Our results can be used per se or as a basis for the future development of more elaborated asymptotic techniques that provide accurate and computationally feasible results.
Mechanical Properties, Tissue Structure, and Elemental Composition of the Walking Leg Tips of Coconut Crabs
Authors: Inoue Tadanobu , Oka Shin-ichiro , Hiroto Takanobu
Published: April 2024

The coconut crab, Birgus latro, has black protrusions on the tops of its walking legs and claw fingers. In addition, there are regularly aligned small black protrusions on parts of the exoskeleton surface of the claws and leg. In this study, the elemental composition, crystal structure, tissue structure, and mechanical properties of these protrusions were studied using a materials science approach, and the results were compared with those of mineralized cuticle. These leg tips were found to be a non-calcified fibrous tissue of α-chitin connected to the mineralized cuticle. The tip of the second walking leg was elongated and had a pointed shape with an oval cavity at its center that was more than 1000 times larger than the pore tubes (100–350 nm) of the mineralized cuticle. It was very soft, with a hardness of 0.4 GPa, corresponding to 11–12% of the hardness of the hard exocuticle and 55–57% of the hardness of the soft endocuticle. The elastic modulus of 8.0 GPa obtained by means of nanoindentation testing was consistent with that of α-chitin fibers of shrimp shells obtained by means of tensile testing. These soft protrusions provide a secure grip on the surfaces of trees or rocks and protect the claw fingertips. It was concluded that the black protrusions are related to a unique ecological (engaging in vertical movements, entering and exiting limestone caves, and escape behavior) aspect of the coconut crab, the largest terrestrial crustacean.
Investigating the Potential Influence of TAS2R16 Genetic Variants and Protein Levels on Multiple Sclerosis Development
Authors: Gedvilaite Greta , Pileckaite Enrika , Ramanauskas Ignas , Kriauciuniene Loresa , Balnyte Renata , Liutkeviciene Rasa
Published: April 2024

The study aimed to investigate the association between the TAS2R16 gene (rs860170, rs978739, rs1357949), TAS2R16 serum levels, and multiple sclerosis (MS). A total of 265 healthy control subjects and 218 MS patients were included in the study. Single nucleotide polymorphisms (SNPs) were tested by real-time polymerase chain reaction (RT-PCR). The serum concentration of TAS2R16 was measured using the ELISA method. Analyses revealed that the TAS2R16 rs860170 TT genotype was statistically significantly less frequent in the MS group than in the control group (p = 0.041), and the CC genotype was statistically significantly more frequent in the MS group than in the control group (p < 0.001). In the most robust (codominant) model, the CC genotype was found to increase the odds of MS by ~27-fold (p = 0.002), and each C allele increased the odds of MS by 1.8-fold (p < 0.001). Haplotype analysis of the rs860170, rs978739, and rs1357949 polymorphisms showed that the C-C-A haplotype was associated with a ~12-fold increased odds of MS occurrence (p = 0.02). Serum TAS2R16 levels were elevated in the MS group compared to control subjects (p = 0.014). Conclusions: The rs860170, rs978739, and rs1357949 polymorphisms demonstrated that the C-C-A haplotype and elevated TAS2R16 serum levels can promote the development of MS. These preliminary findings underscore the importance of specific genetic variants, such as rs860170, rs978739, and rs1357949, in MS risk. Additionally, elevated TAS2R16 serum levels in MS patients suggest a potential role in MS pathogenesis. These findings provide insights into the genetic and molecular mechanisms underlying MS and pave the way for personalized diagnostic and therapeutic strategies. Integrating genetic and serum biomarker data in MS research offers promising avenues for improving clinical outcomes and advancing precision medicine approaches in the future.
Bridging Sustainable Development Goals and Land Administration: The Role of the ISO 19152 Land Administration Domain Model in SDG Indicator Formalization
Authors: Chen Mengying , Van Oosterom Peter , Kalogianni Eftychia , Dijkstra Paula , Lemmen Christiaan
Published: April 2024

This study illustrates the linkages between the ISO’s Land Administration Domain Model (LADM) and the UN’s sustainable development goals (SDGs), highlighting the role of the LADM in promoting effective land administration suitable for efficient computation of land/water (space)-related SDG indicators. The main contribution of this study is the formalization of SDG indicators by using the ISO standard LADM. This paper proposes several SDG-indicator-related extensions to the multi-part LADM standard that is currently under revision. These extensions encompass the introduction of new procedures for calculating indicators, the integration of blueprints for external classes to fulfil additional information needs and the design of interface classes for presenting indicator values across specific countries and reporting years. In an innovative approach, this paper introduces the Four-Step Method—a powerful framework designed to formalize SDG indicators within the LADM framework. Detailed attention is devoted to specific indicators, including 1.4.2 (secure land rights), 5.a.1 (women’s agricultural land rights), 14.5.1 (protected marine areas) and 11.5.2 (valuation as a basis for direct economic loss). In short, the Four-Step Method is pivotal in eliminating ambiguities, enhancing the efficiency of indicator computation and securing more accurate indicator values that more truly reflect the progress towards SDG realization. This approach is also expected to work with other (ISO) standards for other SDG indicators.
Carbon Sequestration Dynamics in Peri-Urban Forests: Comparing Secondary Succession and Mature Stands under Varied Forest Management Practices
Authors: Braga Cosmin Ion , Petrea Stefan , Radu Gheorghe Raul , Cucu Alexandru Bogdan , Serban Tibor , Zaharia Alexandru , Leca Stefan
Published: April 2024

This study examines the impact of silvicultural and land-use management practices on carbon sequestration in peri-urban forest ecosystems, with a particular focus on human-induced carbon dynamics. The study area’s complex profile spans from a compact native forest to varying degrees of fragmentation. This included areas undergoing secondary succession forest without silvicultural interventions (No-SI) alongside sites subjected to high-intensity (High-SI) and low-intensity silvicultural interventions (Low-SI). The research assessed carbon stocks and sequestration in different carbon pools (living biomass, dead organic matter and soil) using field data, allometric equations and laboratory analysis. Findings reveal a significant correlation between the intensity of anthropogenic interventions and variations in carbon stocks. The CASMOFOR model facilitated the reconstruction of carbon stock and carbon-stock change dynamics over four decades (1980–2022), showing disparities in carbon storage capabilities linked to the structural characteristics of the sites. The Low-SI site had the highest carbon stock in all carbon pools (378 tonnes C ha−1), which is more than double compared to High-SI (161 tonnes C ha−1) or No-SI sites (134 tonnes C ha−1). However, the secondary succession forest (No-SI) demonstrated the highest annual carbon stock change (4.4 tonnes C ha−1 year−1), two times higher than the Low-SI mature stand (2.2 tonnes C ha−1 year−1), emphasising the resilience of forest ecosystems to recover and sustain carbon sequestration capacities after harvesting if forest land use remains unchanged. The study underscores the significant importance of anthropogenic interventions on carbon dynamics, especially for living tree biomass, which has consequences in enhancing carbon sequestration and contributing to emission reduction targets.
Impact of Cropland Management on Invertebrate Richness and Abundance in Agroforestry Systems in Bali, Indonesia
Authors: Campera Marco , Chavez Jessica , Humber Coral , Jain Vinni , Cioci Hannah , Aulia Fadilla , Alua Kristiana Aurel , Prawerti Desak Ayu Diah , Ali Sabarian Riskinto Ramadani , Swastika I Wayan , Dusak Putu Gede Bayu Janardhana , Priatama I Putu Ade , Jones Andrew K. , Bulbert Matthew W. , Putra Nyoman Gede Maha , Kuntayuni Kuntayuni , Sukmadewi Desak Ketut Tristiana , Nijman Vincent , Setiawan I Made , Manson Sophie
Published: April 2024

The intensive management of cropland refers to a reduction in habitat complexity (i.e., shade tree cover, tree species richness, crop species richness) to gain more profits. This usually entails a decrease in biodiversity, but agroforestry systems have been shown to provide a solution to the need for profits while maintaining biodiversity and ecosystem services. Invertebrates are important bioindicators since they are not just affected by a decrease in habitat complexity; they are also key for the maintenance of ecosystems given their ecological roles. We aimed to understand how agricultural intensification impacted invertebrate abundance and richness in an agroforestry system in Bali, Indonesia. We set up 53 × 25 m2 plots and collected data via pitfall and pan traps. We linked those data to vegetation data (canopy cover, tree species richness, crop species richness), habitat type (rustic vs. polyculture), and productivity. Overall, we found that the abundance and richness of invertebrate taxa were positively influenced by increasing canopy cover and crop and tree species richness. This supports the habitat heterogeneity hypothesis, which indicates that increased habitat complexity promotes higher invertebrate species richness and abundance. The abundance and richness of certain invertebrate taxa, including agents of biocontrol, were shown to increase in plots with higher yields, thus solidifying the important role of invertebrate communities in the provision of ecosystem services. Harvesting crops from complex agroforestry systems ensures a sustainable income for local communities as well as habitats for invertebrates.
Antivirulence Effects of Trans-Resveratrol and Curcumin on Methicillin-Resistant Staphylococcus aureus (MRSA) from Saudi Arabia
Authors: Alqahtani Maisa , Almukainzi May , Alghoribi Majed F. , El-Mahdy Areej M.
Published: April 2024

Methicillin-resistant Staphylococcus aureus (MRSA) is a common resistant bacterium, whose resistance has expanded to commonly used antibiotics. It is crucial to create novel treatments to tackle bacterial resistance. Trans-resveratrol and curcumin are naturally occurring phenolic compounds, whose effects on MRSA virulence are the subject of this investigation. Sub-MICs of trans-resveratrol and curcumin were tested on the virulence factors of 50 MRSA clinical isolates (CIs), including biofilm, hemolysin, hemagglutination, protease, and lecithinase. The distribution of the virulence factors of the CIs was as follows: hemolysin: 98%, hemagglutination: 70%, protease: 62%, biofilm: 56%, and lecithinase: 52%. The sub-MIC that could reduce the effect of the tested virulence factors by 50% or more (IC50) was observed in the strains that showed susceptibility to the individual administration of trans-resveratrol at 50 µg/mL and curcumin at 20 µg/mL. Hemagglutination and hemolysin activity were inhibited by at least 50% in the majority of CIs (57–94%). Meanwhile, the IC50 for protease and biofilm was observed in 6.5–17.8% of the CIs. A few of the CIs were susceptible to lecithinase inhibition, but all showed a full inhibition. This research supports the possibility of the use of these compounds to reduce the bacterial virulence that can reduce antibiotic utilization, and eventually, they can become a potential alternative treatment in combating bacterial resistance.
Research on Vibration Suppression Methods for Industrial Robot Time-Lag Filtering
Authors: Liu Shichang , Wu Chengdong , Liang Liang , Zhao Bin , Sun Ruohuai
Published: April 2024

This paper analyzes traditional vibration suppression methods in order to solve the vibration problem caused by the stiffness of flexible industrial robots. The principle of closed-loop control dynamic feedforward vibration suppression is described as the main method for solving robot vibration suppression. This paper proposes a method for time-lag filtering based on T-trajectory interpolation, which combines the T-planning curve and the time-lag filtering method. The method’s basic principle is to dynamically adjust the trajectory output through the algorithm, which effectively suppresses the amplitude of the harmonic components of a specific frequency band to improve the vibration response of industrial robot systems. This experiment compared traditional vibration suppression methods with the time-lag filtering method based on T-trajectory interpolation. A straight-line method was proposed to measure the degree of vibration. The results demonstrate that the time-lag filtering method based on T-trajectory interpolation is highly effective in reducing the vibration of industrial robots. This makes it an excellent option for scenarios that demand real-time response and high-precision control, ultimately enhancing the efficiency and stability of robots in performing their tasks.
Saddle-Point Equilibrium Strategy for Linear Quadratic Uncertain Stochastic Hybrid Differential Games Based on Subadditive Measures
Authors: Jia Zhifu , Li Cunlin
Published: April 2024

This paper describes a kind of linear quadratic uncertain stochastic hybrid differential game system grounded in the framework of subadditive measures, in which the system dynamics are described by a hybrid differential equation with Wiener–Liu noise and the performance index function is quadratic. Firstly, we introduce the concept of hybrid differential games and establish the Max–Min Lemma for the two-player zero-sum game scenario. Next, we discuss the analysis of saddle-point equilibrium strategies for linear quadratic hybrid differential games, addressing both finite and infinite time horizons. Through the incorporation of a generalized Riccati differential equation (GRDE) and guided by the principles of the Itô–Liu formula, we prove that that solving the GRDE is crucial and serves as both a sufficient and necessary precondition for identifying equilibrium strategies within a finite horizon. In addition, we also acquire the explicit formulations of equilibrium strategies in closed forms, alongside determining the optimal values of the cost function. Through the adoption of a generalized Riccati equation (GRE) and applying a similar approach to that used for the finite horizon case, we establish that the ability to solve the GRE constitutes a sufficient criterion for the emergence of equilibrium strategies in scenarios extending over an infinite horizon. Moreover, we explore the dynamics of a resource extraction problem within a finite horizon and separately delve into an H∞ control problem applicable to an infinite horizon. Finally, we present the conclusions.
Application of Graph Theory for Blockchain Technologies
Authors: Jayabalasamy Guruprakash , Pujol Cyril , Latha Bhaskaran Krithika
Published: April 2024

Blockchain technology, serving as the backbone for decentralized systems, facilitates secure and transparent transactional data storage across a distributed network of nodes. Blockchain platforms rely on distributed ledgers to enable secure peer-to-peer transactions without central oversight. As these systems grow in complexity, analyzing their topological structure and vulnerabilities requires robust mathematical frameworks. This paper explores applications of graph theory for modeling blockchain networks to evaluate decentralization, security, privacy, scalability and NFT Mapping. We use graph metrics like degree distribution and betweenness centrality to quantify node connectivity, identify network bottlenecks, trace asset flows and detect communities. Attack vectors are assessed by simulating adversarial scenarios within graph models of blockchain systems. Overall, translating blockchain ecosystems into graph representations allows comprehensive analytical insights to guide the development of efficient, resilient decentralized infrastructures.
Natural Language Understanding for Navigation of Service Robots in Low-Resource Domains and Languages: Scenarios in Spanish and Nahuatl
Authors: Hernández Amadeo , Ortega-Mendoza Rosa María , Villatoro-Tello Esaú , Camacho-Bello César Joel , Pérez-Cortés Obed
Published: April 2024

Human–robot interaction is becoming increasingly common to perform useful tasks in everyday life. From the human–machine communication perspective, achieving effective interaction in natural language is one challenge. To address it, natural language processing strategies have recently been used, commonly following a supervised machine learning framework. In this context, most approaches rely on the use of linguistic resources (e.g., taggers or embeddings), including training corpora. Unfortunately, such resources are scarce for some languages in specific domains, increasing the complexity of solution approaches. Motivated by these challenges, this paper explores deep learning methods for understanding natural language commands emitted to service robots that guide their movements in low-resource scenarios, defined by the use of Spanish and Nahuatl languages, for which linguistic resources are scarcely unavailable for this specific task. Particularly, we applied natural language understanding (NLU) techniques using deep neural networks and transformers-based models. As part of the research methodology, we introduced a labeled dataset of movement commands in the mentioned languages. The results show that models based on transformers work well to recognize commands (intent classification task) and their parameters (e.g., quantities and movement units) in Spanish, achieving a performance of 98.70% (accuracy) and 96.96% (F1) for the intent classification and slot-filling tasks, respectively). In Nahuatl, the best performance obtained was 93.5% (accuracy) and 88.57% (F1) in these tasks, respectively. In general, this study shows that robot movements can be guided in natural language through machine learning models using neural models and cross-lingual transfer strategies, even in low-resource scenarios.
Neural Networks with Transfer Learning and Frequency Decomposition for Wind Speed Prediction with Missing Data
Authors: Li Xiaoou , Zhu Yingqin
Published: April 2024

This paper presents a novel data-driven approach for enhancing time series forecasting accuracy when faced with missing data. Our proposed method integrates an Echo State Network (ESN) with ARIMA (Autoregressive Integrated Moving Average) modeling, frequency decomposition, and online transfer learning. This combination specifically addresses the challenges missing data introduce in time series prediction. By using the strengths of each technique, our framework offers a robust solution for handling missing data and achieving superior forecasting accuracy in real-world applications. We demonstrate the effectiveness of the proposed model through a wind speed prediction case study. Compared to the existing methods, our approach achieves significant improvement in prediction accuracy, paving the way for more reliable decisionmaking in wind energy operations and management.
A New Observer Design for the Joint Estimation of States and Unknown Inputs for a Class of Nonlinear Fractional-Order Systems
Authors: Peng Chenchen , Yang Haiyi , Yang Anqing , Ren Ling
Published: April 2024

This article designs an observer for the joint estimation of the state and the unknown input for a class of nonlinear fractional-order systems (FOSs) such that one portion satisfies the Lipschitz condition and the other does not necessarily satisfy such a condition. Firstly, by reconstructing system dynamics, the observer design is transformed equivalently into the tracking problem between the original nonlinear FOSs and the designed observer. Secondly, the parameterized matrices of the desired observer are derived by use of the property of the generalized inverse matrices and the linear matrix inequality (LMI) technique combined with the Schur complement lemma. Moreover, an algorithm is presented to determine the desired observer for the nonlinear FOSs effectively. Finally, a numerical example is reported to verify the correctness and efficiency of the proposed algorithm.
Dynamics of Social Influence and Knowledge in Networks: Sociophysics Models and Applications in Social Trading, Behavioral Finance and Business
Authors: Tsintsaris Dimitris , Tsompanoglou Milan , Ioannidis Evangelos
Published: April 2024

In this paper we offer a comprehensive review of Sociophysics, focusing on relevant models as well as selected applications in social trading, behavioral finance and business. We discuss three key aspects of social diffusion dynamics, namely Opinion Dynamics (OD), Group Decision-Making (GDM) and Knowledge Dynamics (KD). In the OD case, we highlight special classes of social agents, such as informed agents, contrarians and extremists. As regards GDM, we present state-of-the-art models on various kinds of decision-making processes. In the KD case, we discuss processes of knowledge diffusion and creation via the presence of self-innovating agents. The primary question we wish to address is: to what extent does Sociophysics correspond to social reality? For that purpose, for each social diffusion model category, we present notable Sociophysics applications for real-world socioeconomic phenomena and, additionally, we provide a much-needed critique of the existing Sociophysics literature, so as to raise awareness of certain issues that currently undermine the effective application of Sociophysics, mainly in terms of modelling assumptions and mathematical formulation, on the investigation of key social processes.
Boundedness of Solutions for an Attraction–Repulsion Model with Indirect Signal Production
Authors: Wu Jie , Huang Yujie
Published: April 2024

In this paper, we consider the following two-dimensional chemotaxis system of attraction–repulsion with indirect signal production 𝜕tu=Δu−∇·χ1u∇v1+∇·(χ2u∇v2),x∈R2,t>0,0=Δvj−λjvj+w,x∈R2,t>0,(j=1,2),𝜕tw+δw=u,x∈R2,t>0,u(0,x)=u0(x),w(0,x)=w0(x),x∈R2, where the parameters χi≥0, λi>0(i=1,2) and non-negative initial data (u0(x),w0(x))∈L1(R2)∩L∞(R2). We prove the global bounded solution exists when the attraction is more dominant than the repulsion in the case of χ1≥χ2. At the same time, we propose that when the radial solution satisfies χ1−χ2≤2πδ∥u0∥L1(R2)+∥w0∥L1(R2), the global solution is bounded. During the proof process, we found that adding indirect signals can constrict the blow-up of the global solution.
Impact of Backbone Substitution on Organocatalytic Activity of Sterically Encumbered NHC in Benzoin Condensation
Authors: Aysin Rinat R. , Galkin Konstantin I.
Published: April 2024

In this study, we provide a theoretical explanation for the experimentally observed decrease in the organocatalytic activity of N-aryl imidazolylidenes methylated at the C4/5-H positions in the benzoin condensation of aromatic aldehydes. A comparative quantum chemical study of energy profiles for the NHC-mediated benzoin condensation of furfural has revealed a high energy barrier to the formation of the IPrMe-based furanic Breslow intermediate that can be attributed to the negative steric interactions between the imidazole backbone methyl groups and N-aryl substituents.
Temperature-Controlled Divergent Synthesis of Pyrazoles and 1-Tosyl-1H-pyrazoles under Transition-Metal-Catalyst- and Oxidant-Free Conditions
Authors: Wang Kai , Xu Wenjing , Xia Chengcai , Cao Xianting
Published: April 2024

Herein, a general and practical temperature-controlled approach for the divergent synthesis of pyrazoles and 1-tosyl-1H-pyrazoles via electrophilic cyclization in the absence of transition-metal catalysts and oxidants was developed. The desired products were obtained in moderate to excellent yields from common starting materials in both ionic liquids and ethanol by simply tuning the reaction temperature. This strategy employs easily synthesized substrates, mild reaction conditions, and excellent functional-group tolerance.
A Novel Cocrystal of Daidzein with Piperazine to Optimize the Solubility, Permeability and Bioavailability of Daidzein
Authors: Wang Zhipeng , Li Shuang , Li Qi , Wang Wenwen , Liu Meiru , Yang Shiying , Zhang Li , Yang Dezhi , Du Guanhua , Lu Yang
Published: April 2024

It is well known that daidzein has various significant medicinal values and health benefits, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, cholesterol lowering, neuroprotective, cardioprotective and so on. To our disappointment, poor solubility, low permeability and inferior bioavailability seriously limit its clinical application and market development. To optimize the solubility, permeability and bioavailability of daidzein, the cocrystal of daidzein and piperazine was prepared through a scientific and reasonable design, which was thoroughly characterized by single-crystal X-ray diffraction, powder X-ray diffraction, Fourier transform infrared spectroscopy, differential scanning calorimetry and thermogravimetric analysis. Combining single-crystal X-ray diffraction analysis with theoretical calculation, detailed structural information on the cocrystal was clarified and validated. In addition, a series of evaluations on the pharmacogenetic properties of the cocrystal were investigated. The results indicated that the cocrystal of daidzein and piperazine possessed the favorable stability, increased solubility, improved permeability and optimized bioavailability of daidzein. Compared with the parent drug, the formation of cocrystal, respectively, resulted in 3.9-, 3.1-, 4.9- and 60.8-fold enhancement in the solubility in four different media, 4.8-fold elevation in the permeability and 3.2-fold in the bioavailability of daidzein. Targeting the pharmaceutical defects of daidzein, the surprising elevation in the solubility, permeability and bioavailability of daidzein was realized by a clever cocrystal strategy, which not only devoted assistance to the market development and clinical application of daidzein but also paved a new path to address the drug-forming defects of insoluble drugs.
Genistein Prevents Apoptosis and Oxidative Stress Induced by Methylglyoxal in Endothelial Cells
Authors: Liccardo Maria , Sapio Luigi , Perrella Shana , Sirangelo Ivana , Iannuzzi Clara
Published: April 2024

Glycolytic overload promotes accumulation of the highly reactive dicarbonyl compounds, resulting in harmful conditions called dicarbonyl stress. Methylglyoxal (MG) is a highly reactive dicarbonyl species and its accumulation plays a crucial pathophysiological role in diabetes and its vascular complications. MG cytotoxicity is mediated by reactive oxygen species (ROS) generation, a key event underlying the intracellular signaling pathways leading to inflammation and apoptosis. The identification of compounds able to inhibit ROS signaling pathways and counteract the MG-induced toxicity is a crucial step for developing new therapeutic strategies in the treatment of diabetic vascular complications. In this study, the effect of genistein, a natural soybean isoflavone, has been evaluated on MG-induced cytotoxicity in human endothelial cells. Our results show that genistein is able to counteract the MG-induced apoptosis by restraining ROS production, thus inhibiting the MAPK signaling pathways and caspase-3 activation. These findings identify a beneficial role for genistein, providing new insights for its potential clinical applications in preserving endothelial function in diabetic vascular complications.
Moslae Herba: Botany, Traditional Uses, Phytochemistry, and Pharmacology
Authors: Duan Zhuo-Ying , Sun Yan-Ping , Wang Zhi-Bin , Kuang Hai-Xue
Published: April 2024

Moslae Herba (MH) can be used for both medicine and food and has a long history of medicine. MH has the effects of sweating and relieving the exterior, removing dampness and harmonizing, and is mainly used for colds caused by damp heat in summer. It is called “Xiayue Zhi Mahuang” in China. So far, 123 chemical compounds have been isolated and identified from MH, including flavonoids, terpenoids, phenolic acids, phenylpropanoids, and other chemical compounds. Its chemical components have a wide range of pharmacological activities, including antibacterial, antiviral, anti-inflammatory, antioxidant, analgesic sedation, antipyretic, immune regulation, insecticidal, and other effects. In addition, because of its aromatic odor and health care function, MH also has development and utilization value in food, chemical, and other fields. This paper reviewed the research progress of MH in botany, traditional uses, phytochemistry, and pharmacology and provided a possible direction for further research.
Exploring Lifestyle Factors and Treatment Adherence among Older Adults with Hypertension Attending a Mobile Health Unit (MHU) in a Rural Area of Central Portugal
Authors: Pinto Cátia , Chaves Cláudia , Duarte João , Raposo António , Zandonadi Renata Puppin , Monteiro Sara , Teixeira-Lemos Edite
Published: April 2024

This cross-sectional and analytical study aimed to characterize a sample of hypertensive older adults attending a Mobile Health Unit (MHU) in a rural area of central Portugal according to their lifestyle and to analyze the impact of lifestyles on treatment adherence. The sample comprised 235 Portuguese hypertense patients, mainly females (63.8%) with a mean age of 75 years (±8.14 years) and low level of education. The data collection was carried out through a questionnaire consisting of sociodemographic questions, dietary variables, an Alcohol Dependence Questionnaire, an International Physical Activity Questionnaire (Short Version), a Nutrition Health Determination Questionnaire, a Self-Care with Hypertension Scale, and an Adherence to Treatments Measurement Scale. Only 34.5% of the hypertensive patients have controlled blood pressure values (28.2% men and 38% women). However, more than half (56.2%) of the hypertensive patients are classified as adherent to therapeutic measures. The hypertensive individuals, who present higher levels of adherence to the treatment, do not present alcohol dependence, are frequent consumers of aromatic herbs, sporadically consume salt, present good nutritional health, and practice moderate physical activity. The predictor variables for treatment adherence are the self-care dimensions general dietary (p = 0.001), specific dietary (p = 0.034), physical activity (p = 0.031), and antihypertensive medication intake (p < 0.001). Hypertensive patients with healthier lifestyles present better levels of treatment adherence. Therefore, promoting physical activity and healthy dietary practices is necessary to improve treatment adherence and increase antihypertensive treatment’s effectiveness.
Ser9p-GSK3β Modulation Contributes to the Protective Effects of Vitamin C in Neuroinflammation
Authors: Ruggiero Melania , Cianciulli Antonia , Calvello Rosa , Porro Chiara , De Nuccio Francesco , Kashyrina Marianna , Miraglia Alessandro , Lofrumento Dario Domenico , Panaro Maria Antonietta
Published: April 2024

Background. The prolonged activation of microglia and excessive production of pro-inflammatory cytokines can lead to chronic neuroinflammation, which is an important pathological feature of Parkinson’s disease (PD). We have previously reported the protective effect of Vitamin C (Vit C) on a mouse model of PD. However, its effect on microglial functions in neuroinflammation remains to be clarified. Glycogen synthase kinase 3β (GSK3β) is a serine/threonine kinase having a role in driving inflammatory responses, making GSK3β inhibitors a promising target for anti-inflammatory research. Methods. In this study, we investigated the possible involvement of GSK3β in Vit C neuroprotective effects by using a well-known 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of PD and a cellular model of neuroinflammation, represented by Lipopolysaccharide (LPS)-activated BV-2 microglial cells. Results. We demonstrated the ability of Vit C to decrease the expression of different mediators involved in the inflammatory responses, such as TLR4, p-IKBα, and the phosphorylated forms of p38 and AKT. In addition, we demonstrated for the first time that Vit C promotes the GSK3β inhibition by stimulating its phosphorylation at Ser9. Conclusion. This study evidenced that Vit C exerts an anti-inflammatory function in microglia, promoting the upregulation of the M2 phenotype through the activation of the Wnt/β-catenin signaling pathway.