bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Characteristics of Nonparametric and Parameter-Integrated Weighted Average Estimates of Geoecological Measurement Data
Authors:   National Aerospace Agency, Research Institute of Aerospace Informatics, Iskenderzade Elchin Barat oglu , Rahimov Ceyhun Rasif oglu ,   Azerbaijan Technical University, Rahimov Elshan Rasif oglu ,   Baku Higher Oil School, Veliyev Hasan Sarkar oglu
Published: October 2024

A significant amount of work has been devoted to the issues of weighted average assessment of geoecological measurement data. However, there are some gaps in this area in such areas as the study of: the sensitivity ratio of arithmetically and geometrically weighted average nonparametric estimates; the extreme properties of the integral of geometrically weighted average etc. Research in these areas is certainly relevant, as such studies can increase the informative value of the results of the analysis of geoecological measurements. The object of the study is parametric and nonparametric measurement data. The subject of the study is a comparative evaluation of weighted average nonparametric measurement data. The purpose of the work is to develop scientific and methodological foundations for comparative analysis of arithmetically and geometrically weighted average nonparametric measurement data, as well as to study the extreme characteristics of functionals containing, respectively, geometrically weighted average parametric geoecological measurement data and geometrically weighted average geoecological measurement data with parametric weighting coefficients. Research tasks: 1. Comparative assessment of the sensitivities of arithmetically and geometrically weighted average estimates of geoecological indicators. 2. Investigation of the extreme properties of the target functional including arithmetically weighted average estimates of parametric data, in the presence of some restrictive condition. 3. Investigation of extreme properties of geometrically weighted average estimates of geoecological data with parametric weighting coefficients, in the presence of some restrictive condition. Research results and conclusions. The condition of predominance of the sensitivity of the arithmetically weighted average estimate of the measurement data in comparison with the sensitivity using the method of geometrically weighted average estimate is calculated. Objective functionals are introduced for consideration – parameter-integrated indicators: the integral of a geometrically weighted average estimate of geoecological parametric data the integral of a geometrically weighted average estimate with parametric weighting coefficients. The analysis covers a special case when data from two sources are averaged. Using variational methods of analysis, the extreme properties of the introduced indicators are investigated.
Approaches to the Analysis of the Economic Behavior of Rural Regions in the Conditions of Instability (on the Example of the Republic of Buryatia)
Authors:   East-Siberia State University of Technology and Management, Abgaldaev Vladimir Yu. , Osodoeva Olga A. ,   East-Siberia State University of Technology and Management, Saktoev Vladimir E. ,   East-Siberia State University of Technology and Management
Published: October 2024

This article raises the problem of the need for a microeconomic analysis of the economic behavior of rural areas of the Republic of Buryatia in conditions of instability. The object of the study is the rural areas of the Republic of Buryatia as «hot spots» of unstable development of the regional economy. The subject of the study is the interrelations and relationships that shape the behavior of economic entities in the region in conditions of instability. The purpose of the study is to propose a formalized and pragmatic approach to the applied «input-output» method based on the study of price changes in some sectors of the regional economy as an effective tool for identifying shortcomings in the regional strategy of behavior. The methodological tools of the study were microeconomic approaches to the analysis of regional tables «input – output» as a mechanism for developing and defining a common conceptual and categorical apparatus in the field of unstable development of the region. This made it possible to develop and classify the forms of behavior of economic entities based on the input-output method using the microeconomic approach. The authors propose that enterprises diversify their behavior so that it becomes the main element of the stable management of the region’s economy and an incentive for future research on the activities of enterprises using a microeconomic approach.
Green Integration – a New Stage in the Development of the Green Economy of Countries?
Authors:   Financial University under the Government of the Russian Federation, Kononovich Inga V.
Published: October 2024

Turbulence has become the new normal of the countries’ economies in the last decade of the 21st century. The idea of a new economic paradigm of greening economies, the pursuit of sustainable development and an attempt to preserve the biodiversity of our planet has become a new global economic trend, an increasing number of countries include greening the economy in their long-term development strategies. However, the concept of a green economy is idealized and not fully formulated, which complicates the practical implementation of the points of the new economy in the development strategy of countries. A high innovative load, significant costs for the greening of production stop the process of a green economy development. Green integration can become a key solution to the problem of introducing a green economy in many countries; it will contribute to the integration of economic entities, acting as a new stage in the development of a green economy. The subject of the study is green integration, features, prospects and obstacles for the development of green integration as a new stage in the development of the green economy. The purpose of the study is to show that green integration is a new necessary stage in the green economy development in the countries. The methods and methodology of the work: when formulating the concept of “green integration”, the definitions of green economy and integration; methods of retrospective analysis and synthesis are used; the historical stages of development of the green economy have been studied using synthesis methods. Results of the work: the article considers the stages of green economy development, it is shown that green integration, the desire to create which can already be observed on the world stage, and is the fourth stage in the green economy development; a definition of green integration is given, the structure of the “green integration” concept is reflected as well as positive and negative aspects of the green integration introduction within the framework of various integration associations. This article can be applied in the framework of the research on green economy, the problems of countries and integration groups transition to the green economy.
Penerapan Metode Case-Based Reasoning pada Website SORTING (Sorong Atasi Stunting) Sebagai Implementasi Smart City (Studi Kasus: Distrik Sorong Timur)
Authors: Manuhutu Melda , Tindage Jalmijn , Bobii Permenas
Published: October 2024

Stunting is one of the issues designated as a national priority issue at this time. Determining this priority issue is to accelerate the level of achievement of national development goals. East Sorong District, Sorong City, Southwest Papua Province is one of the focus location with a high prevalence rate. This study aims to develop an information technology called SORTING (Sorong Atasi Stunting) using the case-based reasoning method. This research produces a system that can be accessed from anywhere and at any time, which can be used by residents, especially mothers, to consult regarding their baby's growth problems. SORTING was developed using the expertise of nutritionists who usually deal with stunting problems. SORTING resulted in several conclusions that the application expert system can diagnose stunting by using the case-based reasoning method as an engineering approach to the knowledge base; The application of the SORTING expert system can provide an overview of stunting including the results of the percentage of diagnoses, factors and recommendations for solutions that must be taken; The application of the SORTING expert system can be used as a second alternative to consult with experts in diagnosing stunting. And it can also be an alarm to continue consulting with experts directly; The application of the SORTING expert system can increase knowledge about stunting. The researchers hope that SORTING can assist the government in the National Action Plan for Stunting Management which emphasizes reducing stunting rates and can help the community recognize stunting diseases early and prevent them.
Clinical laboratory profiling and microbiological analysis of the oral cavity of dogs (Canis familiaris) with dental disorders
Authors: Costa Rocha Leonardo , de Souza Moraes Emilly , Novais Siqueira Aurioneide , Mendes Brandão Erica , Jasmyne Costa de Carvalho Hyanka , Azevedo Carvalho Isabel , de Araujo Melo Solange
Published: October 2024

Periodontal disease (PD) is caused by the accumulation of biofilm in the oral cavity. Biofilm is a viscous, yellowish film that is initially composed of non-pathogenic bacteria; the biofilm creates an environment that is conducive to the proliferation of pathogenic Gram-negative bacteria if it is not removed, leading to periodontitis. This study identified the bacteria present in oral cavity samples from 22 dogs with dental disorders and related them to clinical and laboratory findings. To identify these microorganisms, samples were collected and cultivated in a variety of culture media and bacterial identification was carried out using biochemical tests. We also performed antimicrobial susceptibility tests to select the most appropriate treatment for each case. The results showed that the dogs in the study presented with anemia, leukocytosis, and increased plasma protein, which were possibly associated with PD. The most severe periodontal changes were observed in dogs between 6 and 12 years old that consumed moist and/or soft foods. We identified eight species of bacteria, including Klebsiella aerogenes, Pantoea agglomerans, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, and bacteria from the genus Clostridium sp. These results highlight the importance of the antibiogram and of restricting the use of broad-spectrum antibiotics as complementary treatment for PD.
Economic and productive performance of broilers subjected to quantitative feed restriction
Authors: Pizolotto Wiliam , Machado Costa Marcio , Zancanaro Gasperin Nadine , Beatriz Rodrigues Laura , Ruschel dos Santos Luciana , Pilotto Fernando
Published: October 2024

Nutrition today accounts for approximately 75% of broiler production costs due to the large variety of ingredients contained in poultry feed. Commercial chicken breeds have been genetically selected for rapid weight gain, among other characteristics, thereby stimulating their voracious feeding behavior. However, this greater feed intake has not seen an attendant increase in the digestion capacity of the birds’ digestive system, thus interfering with feed conversion. The objective of this study to compare the performance of feed conversion, mortality rates, daily weight gain, carcass rejections, carcass and parts yields and the cost of ad libitum feeding of broiler chickens with those achieved through quantitative feed restriction (Cobb broiler diet table and 10% less than recommended in the table). The treatments were tested in three consecutive batches on a poultry farm with three aviaries. The results obtained indicated that quantitative feed restriction improves feed conversion and reduces daily weight gain and mortality rates, but affects neither carcass rejection rates nor carcass and parts yields. As for production costs, the kilogram of live chicken was 5.69% lower among birds that received controlled feed, following the diet recommended for the breed, and 7.38% in birds that received a 10% quantitative feed restriction compared to the Cobb broiler diet table. The results of this study indicate that the use of quantitative feed restriction programs, despite the lower daily weight gain of broiler chickens, can offer advantages because lower mortality rates and enhanced feed conversion compensate for this loss, thus significantly reducing production costs.
Glymphatic System Dysfunction in Congenital Sensorineural Hearing Loss: A DTI-ALPS Study
Authors: Sha Li , Xu Zhen-Gui , Chen Yu-Chen
Published: October 2024

Background:

The neural mechanisms underlying congenital sensorineural hearing loss (CSNHL) remain elusive.

Objective:

This study evaluated the function of the glymphatic system in children with CSNHL compared to normal-hearing children using the DTI-ALPS
approach, which utilizes diffusion tensor imaging along the perivascular space.

Methods:

Twenty-six children with CSNHL and 30 age- and sex-matched healthy controls (HCs) with normal hearing thresholds were recruited. The DTIALPS
index was calculated for each group. We analyzed the discrepancies in the DTI-ALPS index between patients with CSNHL and healthy
controls. Additionally, Spearman's correlation analysis was performed to investigate the relationship between the DTI-ALPS index and age in
children with CSNHL.

Results:

Significant differences in the DTI-ALPS index were observed between the two groups. Compared with HCs, the DTI-ALPS index in CSNHL
patients was significantly lower (1.49388±0.11441 vs. 1.61402±0.15430, p=0.002). In addition, diffusivity along the z-axis in the association fiber
(Dzzassoc) index was significantly higher in the CSNHL group than in the HC group (0.00041±0.00006 vs. 0.00036±0.00004, p=0.003).
Furthermore, we discovered a noteworthy downward correlation between the DTI-ALPS index and age in children with CSNHL (rho = -0.544,
p=0.005).

Conclusion:

In this present study, glymphatic system activity in CSNHL children was investigated for the first time using the DTI-ALPS index. A significant
decrease in glymphatic system function was detected in CSNHL children, which correlated well with age. The DTI-ALPS index could serve as a
valuable biomarker for tracking disease progression and treatment in CSNHL and unraveling the neural mechanisms of early hearing deprivation in
children with CSNHL.
Motion Sickness: Holding the Acupressure Point of Village-Owned Business Entities on the Wheel of “Good Corporate Governance”
Authors: Dewi Amelia Sri Kusuma , Prasetyo Ngesti Dwi , Rifan Mohamad , Habsari Hanugrah Titi
Published: October 2024

The transcription of Good Corporate Governance (GCG) scenarios in various state regulations basically attempts to build plots to move various economic resources from an area with low productivity to an area with higher productivity with greater results. However, this condition is different when the Indonesian Government wants Village-Owned Enterprises (BUMDes) which normatively and culturally are not designed for entrepreneurship like BUMD/BUMN. The consequence of this desire is that in its implementation BUMDes tends to be neglected and not bound by the principles of Good Corporate Governance (GCG). Through juridical-normative research methods and 3 (three) legal approaches, this research focuses on "Motion Sickness" towards BUMDes resulting from their placement in the "return on investment" space without Good Corporate Governance (GCG). The results of this research show that when analogous to a vehicle, BUMDes experience Motion Sickness or nausea due to: First, the psychological burden on the apparatus in the Village Government; Second, the Good Corporate Governance (GCG) Design is not in accordance with the BUMDes Design. Hence, the acupressure points that need to be pressed in dealing with BUMDes problems include: legal revitalization in the Village Law, overcoming work culture (such as fraud and insider transactions), sterilization of political elements (separating the interests of village officials from interests of Business Entities), and expansion of the business environment. So that in the future Corporate Governance and Corporate Management in BUMDes can be realized through the commitment of stakeholders such as: Capital Owners/GMS, Board of Supervisory/Commissioners, and Board of Directors.
The United States’ Assault on Multilateralism: The Crisis in WHO, WTO and ICC
Authors: Yadav Anita , Srivastva Utkarsh
Published: October 2024

The culmination of the second world war marked the beginning of multilateral cooperation amongst nations of the world to achieve peace, security, economic prosperity, and social advancement. The United States led the international movement towards achieving common goals through multilateral efforts during that era. However, in recent years, the United States’ disenchantment with the principle of multilateral cooperation has become increasingly prominent. The authors have adopted descriptive analytical approach to analyse the unilateral actions taken by the United States against three multilateral organisations, namely, the World Health Organization, the World Trade Organization and the International Criminal Court, which have been at the forefront of the United States’ criticism. The article also critically evaluates the criticism by the United States against these organisations. Further, the authors have also explored the shortcoming in terms of the structure and functioning of these organisations. These organisations have long relied on the cooperation between their members to fulfil their mandates in addressing global challenges. The United States' actions against these organizations have demonstrated a disregard for multilateralism and a preference for the age-old dictum of ‘might is right’. The actions of the United States must also be seen from the lens of challenges it faces today, particularly from China and other emerging economies. Perhaps, the United States’ actions can be seen as an attempt to counter the diminishing giant syndrome. Thus, it is imperative for other nations to respond by reaffirming their commitment to collective action and shared responsibilities.
Digital Transformation of Rheumatology Care in Germany: Cross-Sectional National Survey
Authors: May Susann , Darkow Robert , Knitza Johannes , Boy Katharina , Klemm Philipp , Heinze Martin , Vuillerme Nicolas , Petit Pascal , Steffens-Korbanka Patricia , Kladny Heike , Hornig Johannes , Aries Peer , Welcker Martin , Muehlensiepen Felix
Published: October 2024

Background

In recent years, health care has undergone a rapid and unprecedented digital transformation. In many fields of specialty care, such as rheumatology, this shift is driven by the growing number of patients and limited resources, leading to increased use of digital health technologies (DHTs) to maintain high-quality clinical care. Previous studies examined user acceptance of individual DHTs in rheumatology, such as telemedicine, video consultations, and mHealth. However, it is essential to conduct cross-technology and continuous analyses of user acceptance and DHT use to maximize the benefits for all relevant stakeholders.

Objective

This study aimed to explore the current acceptance, use, and preferences regarding DHTs among patients in rheumatology care in Germany.

Methods

Rheumatology patients from 3 clinics in Germany were surveyed to understand their perspectives on DHTs. The survey included main themes, including acceptance, preferences, COVID-19’s impact, potential, and barriers related to DHTs. The data were analyzed using descriptive statistics and correlation analysis.

Results

Out of 337 participants, 53% (179/337) reported using DHTs. Specific technologies included wearables (72/337, 21%), mHealth apps (71/337, 21%), digital therapeutics (32/337, 9%), electronic prescriptions (30/337, 9%), video consultations (15/337, 4%), and at-home blood self-sampling (3/337, 1%). Nearly two-thirds (220/337, 65%) found DHTs useful, and 69% (233/337) held a generally positive attitude toward DHTs. Attitudes shifted positively during the COVID-19 pandemic for 40% (135/337) of participants. Higher education was more prevalent among DHT users (114/179, 63.7%) compared with nonusers (42/151, 27.8%; P=.02). The main potential benefits identified were location-independent use (244/337, 72%) and time-independent use (216/337, 64%). Key barriers included insufficient user knowledge (165/337, 49%) and limited information on DHTs (134/337, 40%).

Conclusions

Patient acceptance and use of DHTs in rheumatology is increasing in Germany. A prospective, standardized monitoring of digital transformation in rheumatology care is highly needed.
Digital Interventions for Managing Medication and Health Care Service Delivery in West Africa: Systematic Review (Preprint)
Authors: Oluokun Emmanuel Oluwatosin , Adedoyin Festus Fatai , Dogan Huseyin , Jiang Nan
Published: October 2024

BACKGROUND

As a result of the recent advancements in technology, the incorporation of digital interventions into the health care system has gained a lot of attention and adoption globally. However, these interventions have not been fully adopted, thereby limiting their impact on health care delivery in West Africa.

OBJECTIVE

This review primarily aims at evaluating the current digital interventions for medication and health care delivery in West Africa. Its secondary aim is to assess the impacts of digital interventions in managing medication and health care service delivery with the intent of providing vital recommendations that would contribute to an excellent adoption of digital intervention tools in the health care space in West Africa.

METHODS

In line with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), a comprehensive search through various databases yielded 529 results. After a rigorous screening, 29 articles that provided information on 3 broad digital health intervention tools were found eligible for this review.

RESULTS

Out of 29 studies, 16 (55%) studies examined phone-based interventions, 9 (31%) studies focused on tele- and e-based interventions, and 4 (14%) studies evaluated digital interventions. These interventions were used for diverse purposes, some of which are monitoring adverse drug reactions, general health, sexual and reproductive health, and training of health care practitioners. The phone-based intervention appears to be the most known and impactful of all the interventions, followed by tele- and e-based, while digital interventions were scarcely used.

CONCLUSIONS

Digital interventions have had a considerable level of impact on medication and health care delivery across West Africa. However, the overall impact is limited. Therefore, strategies must be developed to address the challenges limiting the use of digital intervention tools so that these tools can be fully incorporated into the health care space in West Africa.

CLINICALTRIAL
Correction: Early Prediction of Cardiac Arrest in the Intensive Care Unit Using Explainable Machine Learning: Retrospective Study (Preprint)
Authors: Kim Yun Kwan , Seo Won-Doo , Lee Sun Jung , Koo Ja Hyung , Kim Gyung Chul , Song Hee Seok , Lee Minji
Published: October 2024

UNSTRUCTURED
Assess the capabilities of AI-based large language models (AI-LLMs) in interpreting histopathological slides and scientific figures: performance evaluation study (Preprint)
Authors: Gumilar Khanisyah Erza , Ariani Grace , Wiratama Priangga Adi , Rimbun Rimbun , Yuliawati Tri Hartini , Chen Hong , Ibrahim Ibrahim Haruna , Lin Cheng-Han , Hung Tai-Yu , Anggrahini Dewanti , Rajanagara Arya Satya , Yu Zih-Ying , Hsu Yu-Cheng , Dachlan Erry Gumilar , Yang Jer-Yen , Liao Li-Na , Tan Ming
Published: October 2024

BACKGROUND

Interpreting histopathology slides and scientific figures requires specialized skills and knowledge. Pathologists analyze various tissues and cells, while the general population often struggles with the technical information in scientific figures. Artificial intelligence-based large language models (AI-LLMs) can simplify these processes by providing clearer explanations.

OBJECTIVE

This study explores the capabilities AI-LLMs in interpreting histopathology slides and scientific figures. The objective is to assess the value of AI LLMs in medical applications and scientific education.

METHODS

The study was divided into two parts: interpreting histopathology slides and scientific figures. Six histopathology images and six scientific figures were tested on each of the three most frequently used chatbots (ChatGPT-4, Gemini Advanced, and Copilot). Responses from the chatbots were coded and blindly examined by expert raters using five parameters—relevance, clarity, depth, focus, and coherence—on a 5-point Likert scale. Statistical analysis included one-way ANOVA and multiple linear regression.

RESULTS

ChatGPT-4 outperformed Gemini Adv and Copilot in both histopathology and scientific image interpretation, with significantly higher scores across all parameters (P<.001). High homogeneity among raters validated these findings. ChatGPT-4's superior performance may be due to its advanced algorithms, extensive training data, specialized modules, and user feedback.

CONCLUSIONS

ChatGPT-4 excels in interpreting histopathology and scientific images, which may lead to improving diagnostic accuracy, clinical decision-making, and reducing pathologists' workload. It also benefits education by enhancing students' understanding of complex images and promoting interactive learning. ChatGPT-4 shows a significant potential to improve patient care and enrich student learning.
Acceptance, Drivers, and Barriers to use mHealth Applications to Improve Quality of Life in Female Patients Affected by Hypothyroidism: a Cross-sectional Study (Preprint)
Authors: Doll Moritz , Chandrakumar Ranujan , Jahre Lisa Maria , Skoda Eva-Maria , Dinse Hannah , Führer Dagmar , Lampropulou Eleni , Teufel Martin , Bäuerle Alexander
Published: October 2024

BACKGROUND

Hypothyroidism is a common chronic disease associated with lower quality of life, a trend that interventions delivered by mHealth applications could ameliorate.

OBJECTIVE

The objective of the present study was to assess acceptance, drivers, and barriers to use mHealth applications to improve quality of life in female patients affected by hypothyroidism.

METHODS

A survey-based, cross-sectional study, which included N = 318 female patients affected by hypothyroidism (assessed via self-report) was conducted between April 2023 and April 2024. Sociodemographic, health, and eHealth-related data were assessed. To determine acceptance and its drivers and barriers, an extended version of the Unified Theory of Acceptance and Use of Technology model was applied. Group comparisons and multiple hierarchical regression were conducted.

RESULTS

Acceptance of mHealth applications was high (M = 4.10, SD = 0.91), with 76.1% (n = 242) of the participants reporting high acceptance, 18.6% (n = 59) reporting moderate acceptance, and only 5.3% (n = 17) reporting low acceptance. Significant predictors of acceptance were Place of Residence: Medium-sized city (β = .34, p = .02) and small town or rural area (β = .28, p = .003), Fatigue (β = .54, p < .001), Internet anxiety (β = -.20, p = .002), and the UTAUT predictors Effort expectancy (β = .37, p < .001), Performance expectancy (β = .32, p < .001), and Social influence (β = .20, p < .001). The extended model explained 56.1% of variance in acceptance.

CONCLUSIONS

The high level of acceptance of mHealth applications observed among females affected by hypothyroidism suggests that mHealth interventions can provide such patients with valuable support to manage the disease. Drivers and barriers should be addressed during the implementation of mHealth interventions

CLINICALTRIAL

N/A
Breast and Prostate Cancer Screening by Life Expectancy in Patients with Kidney Failure on Dialysis
Authors: Tran Michelle , Xu Chun Anna , Wilson Jonathan , Hall Rasheeda , Ephraim Patti L. , Shafi Tariq , Weiner Daniel E. , Goldstein Benjamin A. , Scialla Julia J. ,   on behalf of the Comparative Effectiveness Studies in Dialysis Patients Group
Published: October 2024

Key Points

Breast and prostate cancer screening were more frequent among patients on hemodialysis waitlisted for kidney transplant.

Among patients not waitlisted for transplant, we found that screening rates were generally higher among patients with higher predicted 5-year survival.

Among patients not waitlisted for transplant and with the highest predicted 5-year survival, there was a deficit of screening compared with waitlisted patients.

Background

The Choosing Wisely campaign suggests an individualized approach to cancer screening among patients receiving dialysis. We aimed to evaluate breast and prostate cancer screening among patients receiving maintenance hemodialysis by kidney transplant waitlist status and 5-year survival probability.

Methods

We conducted a retrospective cohort study using a nationally representative population of hemodialysis patients. Patients receiving hemodialysis each calendar year from 2003 to 2018, ≥1 year of Medicare as the Primary Payer, and age 50–69 years were included. The cohort was split into prognosis and cancer screening sets. Models of 5-year survival were built in the prognosis set using logistic regression. Five-year survival probabilities were generated in the cancer screening set, excluding patients with prior breast or prostate cancer, and screening over the next year was assessed.

Results

One hundred sixty thousand five hundred thirty-seven patients contributed 356,165 person-years to the cancer screening set (59% of the person-years were contributed by males, median age was 60 years). Compared with a benchmark rate of 50% (e.g., mammography every other year), 42% of waitlisted female-years were screened by mammography. Overall, 17% of nonwaitlisted female-years were screened (20% among those with >50% probability of 5-year survival and 8% among those with <10% probability of 5-year survival). Compared with a benchmark rate of 20% (e.g., serum prostate-specific antigen screening up to 5 years apart), 24% of waitlisted male-years were screened with serum prostate-specific antigen. Overall, 15% of nonwaitlisted male-years were screened (13% among those with >50% probability of 5-year survival and 11% among those with <10% probability of five-survival). Patterns were similar after age-standardization.

Conclusions

Patients with higher predicted survival have higher rates of cancer screening, suggesting providers consider life expectancy. However, nonwaitlisted patients with high probability of 5-year survival were less likely to be screened compared with waitlisted patients. Interventions may be needed to close this screening gap.
Impaired Incretin Homeostasis in Nondiabetic Moderate-to-Severe CKD
Authors: Ahmadi Armin , Gamboa Jorge , Norman Jennifer E. , Enkhmaa Bamba , Tucker Madelynn , Bennett Brian J. , Zelnick Leila R. , Fan Sili , Berglund Lars F. , Ikizler Talat Alp , de Boer Ian H. , Cummings Bethany P. , Roshanravan Baback
Published: October 2024

Key Points

Total incretin levels and incretin response during oral glucose tolerance testing were significantly higher among patients with moderate-to-severe nondiabetic patients with CKD compared with healthy people.

Unlike in healthy individuals, increased incretin response was not correlated with insulin response and coincided with persistently greater glucagon levels to oral glucose tolerance testing in CKD.

Disruption in the incretin system and glucagon dynamics may contribute to metabolic complications in moderate-to-severe CKD.

Background

Incretins are regulators of insulin secretion and glucose homeostasis metabolized by dipeptidyl peptidase-4 (DPP-4). CKD may modify incretin release, metabolism, or response.

Methods

We performed 2-hour oral glucose tolerance testing in 59 people with nondiabetic CKD (eGFR <60 ml/min per 1.73 m2) and 39 matched controls. We measured total area under the curve and incremental area under the curve (iAUC) of plasma total glucagon-like peptide-1 (GLP-1) and total glucose-dependent insulinotropic polypeptide (GIP). Fasting DPP-4 levels and activity were measured. Linear regression was used to adjust for demographic, body composition, and lifestyle factors.

Results

Mean (SD) eGFR was 38±13 and 89±17 ml/min per 1.73 m2 in patients with CKD and controls, respectively. GLP-1 total area under the curve and GIP iAUC were higher in patients with CKD than controls with a mean of 1531±1452 versus 1364±1484 pM×min and 62,370±33,453 versus 42,365±25,061 pg×min/ml, respectively. After adjustment, CKD was associated with 15,271 pM×min/ml greater GIP iAUC (95% confidence intervals [CIs], 387 to 30,154) compared with controls. Adjustment for covariates attenuated associations of CKD with higher GLP-1 iAUC (adjusted difference, 122; 95% CI, −619 to 864). Plasma glucagon levels were higher at 30 minutes (mean difference, 1.6; 95% CI, 0.3 to 2.8 mg/dl) and 120 minutes (mean difference, 0.84; 95% CI, 0.2 to 1.5 mg/dl) in patients with CKD compared with controls. There were no differences in insulin levels or plasma DPP-4 activity or levels between groups.

Conclusions

Overall, incretin response to oral glucose is preserved or augmented in moderate-to-severe CKD, without apparent differences in circulating DPP-4 concentration or activity. However, neither insulin secretion nor glucagon suppression is enhanced.
Research on the Consistency between the New Era College Entrance Examination Evaluation System and Career Planning Education
Authors: Zhang Anqi , Wang Yanlong
Published: October 2024

This paper systematically analyzes the relevant characteristics of career development theory and the core functions, assessment content, and requirements of the college entrance examination evaluation guided by the “China College Entrance Examination Evaluation System” in the context of educational evaluation reform in the new era. It discusses the implementation of career planning education in high school to meet the basic goal of "student-oriented" in the current education evaluation reform, which helps to form a college entrance examination evaluation system of "categorized examination, comprehensive evaluation, and diversified admission". Through investigation and research, it summarizes the policy support and practical situation of implementing career planning education for high school students across the country. Ultimately, it suggests approaches to highlight the principle of "integrated development with dual wings" and to foster students' "meta-competence" in order to enhance career planning education at the high school level.
Periodontitis Treatment by Scaling and Root Planing with Antimicrobial and Anti-Inflammatory Solutions in a Patient with Systemic Lupus Erythematosus
Authors: Cruz-Velasquez Tomas , Ruiz-Reyes Héctor , Rodríguez-Orozco Alain Raymundo
Published: October 2024

Introduction: Systemic Lupus Erythematosus is a chronic autoimmune disease of unknown cause in which patients regularly consume immunosuppressants, causing a decrease in body fluids of proteins such as mucins, immunoglobulin A and G antibodies, which causes destruction of periodontal tissue. Objective: To report a clinical case on the benefits of scaling and root planing (srp) with solutions based on hypochlorous acid (HOCl) and modified diallyl disulfide oxide (mddo) in the periodontal inflammatory process in a patient with systemic lupus erythematosus patient, tubulointerstitial nephritis and periodontitis. Case presentation: A 32-year-old woman, with systemic lupus erythematosus, tubulointerstitial nephritis and, according to the 2017 global workshop on the classification of periodontal diseases and conditions, was diagnosed with Stage 2 and Grade B periodontitis. Periodontal assessment revealed a high overall dental plaque index, with high-risk plaque being the most prevalent. srp treatment was carried out by quadrants, applying a HOCl solution during periodontal debridement and periodontal pockets were irrigated with mddo solution to disinfect them. Conclusions: The antimicrobial and anti-inflammatory solutions used as adjuvants to srp in this novel periodontal irrigation therapy helped to reduce gingival inflammation and high-risk plaque, which favoured healing of periodontal tissues in a patient with systemic lupus erythematosus.
Some physical and mechanical properties of particle boards produced with hazelnut husk and astragalus (Astragalus membranaceus) plant
Authors: Karahan Selim , Guler Cengiz
Published: October 2024

In this study, under laboratory conditions, hazelnut husk and astragalus plant were mixed separately into black pine wood chips, and multi-purpose boards were produced from the obtained chips with urea formaldehyde glue. After the hazelnut husk and astragalus plant were dried and ground, they were added to the chip and glue mixture in certain proportions. Hazelnut husk mixture ratios were applied as 100 %; 0 %, 75 %; 25 %, 50 %; 50 %, 25 %; 75 %, 0 %; 100 % to black pine wood chip in the particle board mixture. These ratios were made in the same way for the astragalus plant. From these mixtures, chipboard blanks of 16 mm thickness and densities between 0,68 g/cm3 and 0,72 g/cm3 were produced. Density, moisture content, thickness increase, water intake, bending strength, modulus of elasticity in bending and tensile strength perpendicular to the surface were tested in physical and mechanical experiments. According to the results obtained, as the participation rate of hazelnut shells and astragalus increased, the durability properties of the panels decreased. At the same time, it shows that the technological properties of the panels produced by adding up to 25 % astragalus plant and hazelnut shells to the mixture comply with the standards.
Mapping of segments of the economic ecosystem of the territory
Authors:   Уральский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Екатеринбург, Россия, Евгений Васильевич Попов , Игорь Павлович Челак ,   Уральский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Екатеринбург, Россия, Максим Михайлович Скворцов ,   Уральский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Екатеринбург, Россия,   Правительство Тюменской области, Тюмень, Россия
Published: October 2024

Relevance. The rapid introduction of digital technologies into economic activity has marked a new paradigm of economic analysis – the analysis of economic ecosystems. The relevance of the structural study of the economic ecosystems of territories is due to both the weak elaboration of this topic in the world and domestic scientific literature, and the practical need for the formation of scientifically based strategies for the socio-economic development of territories. Goal. The purpose of this study is to develop a methodology for mapping the economic ecosystem of the territory. Materials and methods. The object of this study is the economic ecosystem of the territory. The subject of the study is economic relations for the development of the economic ecosystem of the territory on the basis of mapping its elements. The information base of the research was scientific publications indexed in the Scopus and RSCI databases, as well as the author's results on public management of the development of economic ecosystems. The method of logical system analysis is used as a research method. Results. As a result of the conducted research, a scheme of a map of the industry and sphere of activity of the economic ecosystem is proposed, including indicators, participants, products of activity, development trends, assessment experts and conclusions on the development of this sphere of economic activity. An algorithm for mapping the economic ecosystem of the territory has been developed, which includes the stages of segmentation, the formation of maps of industries, the assessment of development projects and the formation of a strategy for the socio-economic development of the territory. Using the example of the development of the Tyumen region, the applicability of mapping segments of the economic ecosystem of the territory for public management of the development of various fields of activity is shown. The novelty of this study lies in the development of the author's approach to mapping segments of the economic eco-system of the territory, which develops the theory of modeling the structure and development of elements of economic ecosystems.
Threats to food security in Russia and import substitution tools
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Татьяна Павловна Черкасова , Григорий Николаевич Героев ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: October 2024

The issues of food security of national states have become particularly relevant in the modern era of global turbulence, when geopolitical threats have generated sanctions pressure, breaking production chains, including in the agricultural sector. In this regard, the issues of food sovereignty require the search for new instruments of state policy for its preservation. The article presents conceptual approaches to the study of food security, which made it possible to identify the basic factors of ensuring it, as well as the main categories of threats. Conducted analysis of the legal framework of the concept of food security and the main conditions for ensuring it in Russia made it possible to specify 4 main groups of threats and determine options for their prevention. The results obtained became the basis for proposing directions for increasing food security in Russia.
Innovative technologies in public administration: digitalization of processes and their effectiveness
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Татьяна Владимировна Игнатова , Дарья Евгеньевна Иванова ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Вячеслав Евгеньевич Иванов ,   Волгодонский филиал Ростовского юридического института МВД России, Волгодонск, Россия, Арина Александровна Сибилева ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: October 2024

The article analyzes innovations and trends in the framework of digital transformation from the point of view of economic, political, managerial and social spheres. The authors consider the trends of converting offline services to an online format, as well as the software and hardware support necessary for this transition. The aspects of optimizing work processes in all these areas when using information and digital technologies are studied. Conclusions are drawn about the need for the development and wide-spread transformation of offline services into a digital format.
To the strategy of managing environmental safety of the Russian Federation and its regions in modern conditions
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Александр Васильевич Кокин , Людмила Николаевна Тимейчук ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: October 2024

In connection with the upcoming review of the Strategy for Environmental Safety until 2025, it is foreseen that changes and additions to it will be necessary in new socio-economic and political conditions. At the global level: due to the unidentified causes (natural or anthropogenic) affecting global climate change, the RF should withdraw from the Paris Agreement on Climate due to fundamentally incorrect estimates of contribution of countriesCO2 issuers in relation to the area of their territories. Because the share of CO2 emissions per unit area in the Russian Federation is much lower than in other countries, with very low population density and dispersion over production and infrastructure. In the exchange processes on the territory of the Russian Federation, up to 46,5% covered by forests, vegetation is able not only to bind anthropogenic CO2, but also to produce significant amounts of oxygen in the Earth’s atmosphere compared to other countries. Therefore, when investing capital in the Russian economy, countries with a large contribution of anthropogenic CO2 per unit of area must pay an environmental rent. At the regional level, the new direction of the Strategy for ensuring environmental safety of regions should be gradually moved to the assessment of territories not by the level of anthropogenic loads on the environment, but by the amount of their assimilation potential, as an indicator of the ability of nature itself to restore the quality of the environment in natural and economic complexes; to an adaptive system of natural resources management, according to the need not to fight against emergencies, related to climate change (landscape fires, mudslides, floods and so on), and adapt to environmental changes through the systematic relocation of infrastructure and production to less affected areas.
The Effect of Habits of Mindo n Junior High School Students’ Mathematics Communication Ability
Authors: Veni Aprilia Dwi Astuti  , Yuliani Anik
Published: October 2024

This research aims to determine the effect of habits of mind on junior high school students' mathematical communication skills on triangles and quadrilaterals. Habits of Mind is defined as a habit of thinking that is carried out as an intelligent behavior pattern when faced with a problem whose solution isn’t easily known so that productive action occurs. The problem in this research is motivated by its importance habits of mind in learning mathematics and improving students' mathematical abilities. The method used in this research is method ex post facto. The population in this study were all class VIII students in one of Junior High Schools in Karawang Regency. The sample in this study was 42 students using the technique purposive sampling. The instrument used in this research is a test, namely mathematical communication skills which consists of 5 (five) description questions. Apart from that, it also uses non-test instruments in the form of questionnaires habits of mind which consists of 30 statements. Data analysis was carried out using simple linear regression techniques. The research results obtained a linear regression equation Y = -25.065 + 1.345X. The magnitude of the correlation coefficient r2 = 0.848 and coefficient of determination = 84.8%. This shows that there is habits of mind had an influence on students' mathematical communication skills of 84.8%, while 15.6% was influenced by other factors not measured in this research.