bluuebunny/crossref_metadata_2025 huggingface dataset:
PARADOXES OF MODERN INSTITUTIONAL DEVELOPMENT OF PEASANT (FARMER) FARMS
Authors: ANDRIANOVA Elena V. , DAVYDENKO Vladimir A. , Khudyakova Yuliya
Published: April 2022

The work is devoted to the study of the constructive nature of institutions in the space of rural territories in the context of social contradictions, often taking paradoxical formats. Methodologically, the article is written in the traditions of modern critical institutional economics and institutional sociology. The authors’ results of the analysis of statistical data from open sources within the framework of the proposed issues over the past 20 years are presented. Three main historical stages of institutional dynamics in agriculture are characterized, the main of which included the introduction and institutionalization of private ownership of land, effectively returning Russia to the number of global players in the agricultural market. The article presents data on the modernization of agriculture resulting from institutional changes “from above” and institutional mutual obligations in rural areas “from below”. The conclusion is made about the increase in land assets and the growth of the total income of landowners. Quantitative indicators of the development of small- and medium-sized peasant (farmer) farms and large landholdings in Russia (agricultural holdings) according to various reporting data are presented. The socio-economic contradictions are revealed that point to the paradoxical development of rural areas of Russia. The foreign experience of managing modern rural business is presented, which can be considered as options for a possible future of Russia. The authors come to the conclusions that the Russian institutional dynamics in rural areas demonstrates several positive changes that have created the basis for the existence and further development of the country in a short period by historical standards. The article puts forward five hypotheses regarding the institutional development of rural areas, some of which are practically verified. It is proved that at present in Russia the risks and dangers of quantitative and qualitative food shortages have really been overcome, and that sufficiently powerful socio-class groups of landowners have been formed who are fundamentally interested in the qualitative reproduction of rural areas, despite the deepening processes of poverty, which marks the paradoxical institutional dynamics. However, there are indications that application of the concept of global instability (including determinants of СOVID-19 pandemic and “special military operation in Ukraine” after 24 February 2022) marks the existence of a new paradox related to the tragedy of agriculture’s future in Russia. It may realistically result in evolutionary crisis of the civilization if we take into account the paradigm of a “folding civilization” introduced by Arkady and Boris Strugatsky, which means that the civilization under study is left defenseless against “Masters of Fools”.
PERCEPTION OF THE CRISIS: THE EXPERIENCE OF THE COVID-2019 PANDEMIC
Authors: ROMASHKINA Gulnara F. , KHUDYAKOVA Marina V.
Published: April 2022

Research purpose of this article is to identify the impact of the crisis phenomena associated with the pandemic on people’s evaluation of the current and future periods of their lives. The scientific novelty is due to the receipt of unique empirical data to characterize the current trends in social optimism in society (using the example of the population of the Tyumen Region) and in understanding of how people reacted to the processes associated with the pandemic.
The empirical base consists of the results of sociocultural monitoring in the Tyumen Region for the period from 2006 to 2021. The research sampling is stratified, random within quotas based on sex and age structure and territory that represent the population of the Tyumen region. The authors studied the main socio-demographic characteristics — components of social optimism: comparison of the results of the current year with the previous one, and the evaluation of the near and distant future. The article demonstrates that public opinion reacts to crisis phenomena in the evaluation of the present moment, but the depth and duration of the crisis influence the evaluation of the future. Over the period from 2006 to 2017, two-thirds of residents of the Tyumen Region maintained strategic optimism — the hope that everything would be fine in the future, but in the last three years their share began to decline. The socio-economic consequences of the COVID-19 pandemic remained the dominant pattern for the residents of the Tyumen Region even in the spring of 2021. Indicators that are statistically consistently related to the perception of consequences and behavior during the pandemic are associated with social optimism (primarily in the evaluation of the current year), age, work experience, type of settlement. When compared with urban residents, rural residents answer that nothing has changed in their lives much more often, they also note the decrease in income and earnings more rarely. But the most significant differences take place on the optimism/pessimism axis. Optimists choose a proactive strategy, rely on their own capabilities; they are twice as less likely to lose their jobs, experience a decrease in income and earnings; they take on additional work more than twice as often. Meanwhile, pessimists expect further deterioration of their lives. The study showed that people who have been ill or whose relatives have been ill during the pandemic, are significantly less likely to be in the group of optimists. Among them, the frequency of responses of the active-achievement type decreases sharply. The direction of the revealed connection remains unclear since qualitative research is needed.
FEATURES OF THE MODERNIZATION OF THE PETROPHYSICAL RESEARCH COMPLEX FOR THE IMPLEMENTATION OF THE POSSIBILITY OF GAS FILTRATION TOGETHER WITH WATER-OIL FLUIDS
Authors: KUZINA Olga A. , POTOCHNYAK Igor R. , PULDAS Lyudmila A.
Published: April 2022

A series of works was carried out to modernize the domestic automated software-measuring complex, designed to find the function of relative phase permeabilities in two-phase oil-water filtration, in order to equip it with the additional ability to filter gas together with two fluids.
The creation of a software-measuring complex that allows to study three-phase filtration is an urgent task of a complex analysis of a field. Complexes produced by the industry with the possibility of three-phase filtration have a high cost. In this regard, there is a need to create a structurally simple and low-cost method for gas filtration, which is the subject of this work.
In order to carry out gas filtration in the software-measuring complex, an intermediate stainless steel tank is installed in the area intended for creating reservoir pressure. Thus, part of the gas from the cylinder goes to the back pressure regulator, thereby forming reservoir pressure, and part is diverted to an intermediate reservoir. A pressure regulator is installed to regulate the gas flow. In this variant, gas is supplied directly to the end of the core holder in parallel with the water line, so fluids and gas are directly mixed in the body of the core holder.
Methodical experiments on filtration of a gas-liquid mixture with subsequent determination of the volumetric flow rate of gas using the equation of state of a real gas were carried out. An analysis was made of the possibility of using this modernization of the installation for further study of three-phase or two-phase filtration.
EXPERIMENTAL INVESTIGATION OF THERMOHYDRODYNAMIC PROCESSES DURING FILTRATION OF WATER-OIL EMULSIONS
Authors: Asylgareev Albert A. , SHARAFUTDINOV Ramil F. , VALIULLIN Rim A. , KOSMYLIN Denis V.
Published: April 2022

Temperature measurements in downhole conditions (well thermometry) are widely used in monitoring the development of oil and gas reservoirs. With the use of thermometry many oilfield tasks are solved: determination of the working intervals, behind-the-casing flows, casing leakage etc. Variation of temperature in formation is caused by thermodynamic effects: Joule-Thomson and adiabatic. One of the main effects in determining the working intervals by downhole thermometry methods is the Joule-Thomson effect, which is associated with the Joule-Thomson coefficient, characterizing the composition of the fluid flowing from the perforated formation into the well. Therefore, it is necessary to know the value of Joule-Thomson coefficient for different fluids, especially it is important for quantitative interpretation of thermometry data.
Currently, the Joule-Thomson coefficient is well studied for various pure fluids and gases, but practically not investigated for emulsions of different types. Meanwhile, the inflow of oil and water from the formation often leads to the formation of emulsion in the bottomhole zone of the formation. Therefore, experimental determination of Joule-Thomson coefficient for such systems and study of thermohydrodynamic processes during emulsion filtration is relevant.
The paper presents the results of experimental studies of thermohydrodynamic processes during filtration of emulsion through a choke cell. The description of the experimental setup and the experimental procedure are given. The main design features of the throttle cell, approaches to reduce heat transfer during the movement of fluid through the throttle cell are discussed in detail. The data of experimental studies of temperature and pressure changes during filtration of type “oil in water” — oil dispersion in water and reverse emulsions of type “water in oil” — water dispersion in oil on the throttling cell are given. The paper also obtained estimates of the Joule-Thomson effect for liquids like water, oil and oil-water emulsions.
Regional Problems of Labour Productivity Rise (illustrated by the Krasnodar area)
Authors: Khokhlova T. P.
Published: April 2022

The article deals with researching the problem of labour productivity rise in the Krasnodar area as a key factor of attaining sustainability and further development of the region economy. Based on dynamic analysis the indexes of labour productivity in Russia, federal area and some entities of the Russian Federation were compared and principle trends and factors of labour productivity drop in the Krasnodar area were identified. It was shown that low, in comparison with the leading entities, labour productivity acts as the major reason for reducing the rate of social and economic development in the area. The authors analyze the content of the strategic program ‘Labour Productivity Rise’ elaborated in the context of the principle project ‘Smart Kuban – Leaders of the Future’ in order to implement the Strategy of social and economic development of the Krasnodar area up to 2030. Key factors of strategic development and approaches to increasing efficiency and labour productivity in the area were identified, including those that can be attained at the expense of technical re-equipment of labour, introduction of advanced methods and technologies, scientific and innovative measures and improving material incentives of workers. The use of all these methods can provide synergy effect that will ensure sustainable development of economic potential of the region.
Vectors of Developing Personnel Potential in Science
Authors: Molchanov I. N.
Published: April 2022

Success of academic work depends greatly on the level and dynamic of developing academic potential and its integral part, i.e. personnel potential. The goal of the research is to study the standing of academic potential, to compare its key characteristics in leading countries of the world selected for the research and to search for funds necessary for improving the efficiency and effectiveness of academic work. In the research the following methods were used: system and historic approaches, methods of induction and deduction, statistic and economic analysis, sociological observations, content analysis and expert assessments. The author found the dependence of academic work results on the standing and dynamics of personnel potential development in conditions of passing over to industry 4.0. New trends in state policy in science were identified, which are stipulated by globalization (de-globalization) processes, fast proliferation of information and communication technologies, steps aimed at overcoming social and economic after-effects of the corona-virus pandemic. The interrelation between specific features of the organization and financing of academic institutions and final results of their functioning was demonstrated. The author proved the key role of personnel potential of science and showed its impact on state policy. The necessity of choosing vectors of development and transformations in state policy in science was substantiated. The article drew conclusions about the need of further changes in science, search for innovative forms of academic work regulation and their practical use for strengthening the material and technical base and personnel potential of science.
Marketplace as Tool of Rising Accessibility of Finance Services
Authors: Garnov A. P. , Zakharova E. V. , Afanasyev E. V.
Published: April 2022

Digital technologies have drastically changed finance service market. A new step in Russian finance market development is connected with the project ‘Marketplace’. The article studies stages of this project development, identifies factors promoting its speedy development, among which the increase in demand for finance services, inflow of individuals’ funds to finance market and others. The authors describe advantages, drawbacks and risks that finance marketplaces represent for finance organizations and finance service consumers. On the basis of information of search requests a conclusion can be drawn that popularity of the tool is growing rather fast. Barriers impeding the development of finance marketplaces are shown. According to the forecast, in the coming years we can expect exponential growth in the number of finance marketplace participants in case of the stable political and economic situation. A set of measures aimed at supporting the development of platforms for individual entrepreneurs and legal entities should be devised.
Digitalization Potential in Production Sphere
Authors: Baurina S. B.
Published: April 2022

Global virtualization of production, new challenges and goals of society informatization made today’s production companies change their own production processes in order to retain competitiveness on market. Standard approaches to production management now cannot guarantee stable profitability of business. The concept of smartproduction and wise factories targets at integration of people, information and value chains in one network. It can provide a new impulse to labour productivity, predetermine new opportunities for improving the work efficiency. Today’s foreign and home literature shows academic interest in new production technologies. In spite of various trends and approaches to the subject, principle priorities of advanced smart production processes have not been revealed adequately, which proves the necessity to continue research in this field. The article substantiates the demand for production process digitalization at Russian enterprises. Possibilities of using artificial intellect and introducing smart-production in industry are studied. Priorities of the advanced Russian production companies in the field of digitalization were highlighted: wider use of cloud technologies; predictive analysis; IaaS-services, i. e. virtual centers of data processing and systems of data storage; centralized dispatcher control and data collection (SCADA) and others. The author characterizes parameters of monitoring development of smart production systems on the territory of the Russian Federation, which has been carried out by Rosstat since 2020. The forecast data on assessing the required resources in respect to support tools on behalf of state were shown, aimed at developing technologies of smart production. Target indicators of developing smart technologies were identified within the frames of the federal project ‘Digital Technologies’. The author systematized science-intensive technological innovations, non-standard solutions and advanced tools of managing production systems, specified target indicators of principle technological trends in smart-production development and substantiated lines in the development of smart-potential of Russian industry.
Global and Russian Market of Chemical Products: Key Trends of Development
Authors: Sizova J. O.
Published: April 2022

Chemical industry is one of the leading and most essential spheres of economy. The article studies specific features and makes a comparative analysis of chemical industry production in Russia and the world, analyzes the structure of trade turnover according to Clause 6 of the uniform goods nomenclature of the foreign economic activity in the Eurasian Economic Union. Key challenges and prospects of development of this industry were identified. To make a comparison the author studied international chemical industry including hundreds of companies working with prospecting, treatment and distribution of gases and with the development of the most complicated organic chemicals used for pharmaceutical preparations. Russian chemical industry possesses resource potential for development but current problems hinder its progress. The major reasons are the following: the shortage of Russian competitive chemical equipment, expensive renewal of existing outdated capacities. At the same time it is possible to mention a low level of research and technical and HR potential of the industry. The author proposes approaches to the development of home chemical industry to provide a growth in output and a rise in competitiveness of this sector of Russian economy on the global level.
From Planned Economy to the Internet Era: Economic Behavior Transformations of Russian Customers
Authors: Barinova N. V. , Barinov V. R.
Published: April 2022

One of the most significant lines in economic studies is investigation of economic behavior of individual. The article analyzes key approaches to studying economic behavior of agents within the frames of behavioral economics that arouses higher and higher interest today. The authors provide definitions of the term ‘economic behavior’ that can be found in academic literature. The principle content of the article is made up by studying economic behavior of Russian customers in conditions of economic transformations within the period from the 1970-s to the early 21st century. The research marked stages of economic reforms of this period and analyzed the impact of different factors on shaping the model of behavior in each of the mentioned periods. The authors draw conclusions about trends of developing economic behavior of customers in the era of digitalization and introduction of artificial intellect in the field of making economic decisions.
Monitoring Global Spread of Trademarks: Empiric Analysis
Authors: Galkin D. G. , Pospelova I. N.
Published: April 2022

The goal of the research is to elaborate recommendations dealing with shaping and using trademarks within the frames of national and international registration systems and to represent the condition and trends of trademark spread through analyzing data published by the World Organization of Intellectual Property and the national patent department (Rospatent). In the research such methods as deduction, scientific abstraction, logistic analysis and analogues were used. The authors study the national and international systems of trademarks registration. To show their interaction a universal model of developing and using trademarks was advanced. The article assesses the current global processes in spreading trademarks and compares the rates of filling applications for trademarks in the world and in Russia in 2010–2020. Countries were ranged by the number of application registrations, dynamics and structural changes in filling applications for trademarks among the Madrid system countries were described and the link between application filling and economic cycles was identified. The role of China and the place of Russia were depicted in modern trends of application filling according to the Madrid system. The authors think that the mentioned characteristics can help identify lines in trademarks spread within the short-term period.
Economic Analysis of Innovation Development Processes in Agriculture of the Republic of Uzbekistan
Authors: Rustamova I. B. , Babadjanova M. M.
Published: April 2022

The article provides econometric analysis of agricultural production efficiency in the Republic of Uzbekistan. As methodology for identifying the impact of land, labour resources and capital on the net output of agriculture Kobba - Douglas production function was used. The results of analyzing parameters of the production function let the authors make a conclusion about the necessity to work out a new concept of innovation development and a new model of efficient running of agriculture and its development on the basis of innovative technologies and agrarian sector diversification. The plotted econometric model is statistically reliable and it can show the state of the net output of Uzbekistan agriculture. Kobba – Douglas production function by the net output of Uzbekistan agriculture and factors affecting it, as well as all its parameters checked by Fisher criterion, Student t-criterion and Darbin – Watson DW-criterion showed that the function by parameters meet all the requirements, which testifies to the possibility to use the model (multiplying model in the form of variables’ product) for the current analysis and future forecast of the net output of the Republic agriculture. On the basis of system econometric analysis the forecast parameters of the net output up to 2025 were identified that were found by raising efficiency of innovative processes in agriculture.
Bioactive Compounds and Diabetes Mellitus: Prospects and Future Challenges
Authors: Rahman Md. Mominur , Islam Md. Rezaul , Rabbi Fazle , Islam Mohammad Touhidul , Sultana Sharifa , Ahmed Muniruddin , Sehgal Aayush , Singh Sukhbir , Sharma Neelam , Behl Tapan
Published: April 2022

Diabetes mellitus is a metabolic condition that influences the endocrine framework. Hyperglycemia and hyperlipidemia are two of the most widely recognized metabolic irregularities in diabetes and two of the most well-known reasons for diabetic intricacies. Diabetes mellitus is a persistent illness brought about by metabolic irregularities in hyperglycemic pancreatic cells. Hyperglycemia can be brought about by an absence of insulin-producing beta cells in the pancreas (Type 1 diabetes mellitus) or inadequate insulin creation that does not work effectively (Type 2 diabetes mellitus). Present diabetes medication directs blood glucose levels in the systemic circulation to the typical levels. Numerous advanced prescription medicines have many negative results that can bring about unexpected severe issues during treatment of the bioactive compound from a different source that is beneficially affected by controlling and adjusting metabolic pathways or cycles. Moreover, a few new bioactive medications disengaged from plants have shown antidiabetic action with more noteworthy adequacy than the oral hypoglycemic agent that specialists have utilized in clinical treatment lately. Since bioactive mixtures are collected from familiar sources, they have a great activity in controlling diabetes mellitus. This study discusses bioactive compounds, their activity in managing diabetes mellitus, and their prospects. Though bioactive compounds have many health-beneficial properties, adequate clinical studies still need to acknowledge that they effectively manage diabetes mellitus.
The Effect of Ramosetron on Remifentanil in Preventing Emergence Cough from
Sevoflurane Anesthesia in Female Patients
Authors: Kim Ji Ho , Lee Ga Yun , Lee Hye Sun , Park Sung Yong
Published: April 2022

Background:

Remifentanil reduces cough during extubation. Ramosetron, a 5-HT3 receptor antagonist,
is a potent antiemetic. Regarding the antitussive property of 5-HT receptor agonists, ramosetron can mediate
the cough reflex by increasing the remifentanil requirement. This study evaluated the effect of ramosetron
on the optimal effect-site concentration (Ce) of remifentanil for preventing emergence cough from sevoflurane
anesthesia in female patients.

Methods:

Forty-seven randomly selected female patients undergoing laparoscopic cholecystectomy received
either ramosetron 0.3 mg (n = 23) or the same volume of normal saline (n = 24) intravenously at the end of surgery.
The remifentanil Ce using target-controlled infusion in 50% of patients (EC50) and 95% of patients (EC95)
were assessed using Dixon’s up-and-down or isotonic regression method with a bootstrapping approach.

Results:

Using Dixon’s up-and-down method, the EC50 of remifentanil in the control group (1.33 ± 0.38 ng/mL)
was comparable to that of ramosetron group (1.50 ± 0.69 ng/mL) (P = 0.615). Using isotonic regression analysis,
the EC50 (83% confidence interval) did not differ between the two groups (1.17 [0.86-1.43] ng/mL and 1.13
[0.68-1.56] ng/mL in control and ramosetron groups). However, the EC95 (95% confidence interval) was significantly
lower in the control group than in the ramosetron group (1.90 [1.45-1.96] ng/mL and 2.92 [2.35-2.97]
ng/mL).

Conclusion:

Remifentanil Ce for preventing emergence cough was higher in the ramosetron group than in the
control group. It may indicate the lowering effect of ramosetron on the antitussive activity of remifentanil.

Clinical Trial Registration No:

(KCT0005441).
Ang-1 Inhibited Endoplasmic Reticulum Stress and Apoptosis of VECs in
Rats with aSAH-induced CVS Through the Regulated PI3K/Akt Pathway
Authors: You Chao , Wei Pingbo , Han Yangyun , Chen Hao , Luo Le , Liu Gang , Lin Bing , Gong Hao
Published: April 2022

Aims:

To explore angiopoietin-1 (Ang-1) involved in cerebral vasospasm (CVS) after
aneurysmal subarachnoid hemorrhage (aSAH) through its effect on endoplasmic reticulum stress
(ERS) and apoptosis of vascular endothelial cells (VECs).

Background:

CVS accounts for high morbidity and mortality of aSAH. Abnormal cellular physiological
processes of VECs play a critical role in aSAH-induced CVS. In addition, Ang-1 is involved
in regulating vascular structure and function.

Objective:

To study the role of Ang-1 played in CVS and the underlying mechanism.

Methods:

Blood samples of 130 aSAH patients were collected from 2016 to 2020 at West China
Hospital of Sichuan University. A two-hemorrhage rodent model was employed to structure an
aSAH-induced CVS rat model. Moreover, oxyHb was used to treat VECs to construct a CVS cell
model in vitro. ELISA was used to measure the level of Ang-1 and HE staining to assess the rat's
basilar arteries. Subsequently, CCK-8 was used to detect cell viability ability, and flow cytometry
was used to test the cell apoptosis rate. Western blotting was used to determine the expression level
of ERS marker and apoptosis-related proteins.

Results:

There was an abnormally low expression of Ang-1 in CVS patients and CVS rats; besides,
oxyHb treatment decreased Ang-1 in VECs in a concentration-dependent manner. Ang-1 treatment
led to the thinner basilar artery wall and lumen circumference in CVS rats; moreover, in oxyHbtreated
VECs, Ang-1 treatment inhibited ERS and apoptosis. In addition, the expression of p-PI3K
and p-Akt in the CVS group decreased, while the expression of p53 in the CVS group increased.
The expression of p-PI3K and p-Akt in 8 CVS rats negatively correlates with the expression of Ang-
1, but the correlation between p53 and Ang-1 was positive. Furthermore, the results suggested that
Ang-1 suppressed ERS and apoptosis of VECs through the regulated PI3K/Akt/p53 pathway.

Conclusion:

Elevated Ang-1 inhibited p53-mediated ERS and apoptosis of VECs through the activated
PI3K/Akt pathway; Ang-1 might be an attractive treatment strategy for CVS.
Restraint Stress Impacts on Behavioral Changes and Adrenal and Kidney Tissue Histopathology of Adult Mice
Authors: Reyhanditya Davy , Hikmawati Viona Faiqoh , Kurnianingsih Nia , Fatchiyah Fatchiyah
Published: April 2022

Restraint stress causes changes in the brain parameters. Little research has been done on the impact of restraint stress on other tissues, including adrenal glands and kidneys. This study aimed to determine the effect of restraint stress on eating behaviors, depressive-like, anxiety-like behaviors, weight gain as well as histopathological changes in the kidneys and adrenal glands. Twenty adult BALB/c mice were assigned into control male, stressed male, control female, and stressed female. Restraint stress was applied two hours/day for 14 days. Tail suspension and open field tests were carried out to perform behavior analyses. Adrenal and kidney histological slides were observed under an Olympus CX-31 microscope and visualized using an Olympus E330 camera. The two-way ANOVA test was used for statistical analysis using GraphPad Prism 9.0.0 software. We found that restraint stress defeat appetite and reduces weight gain particularly in stressed female. However, depressive- and anxiety-like behavior were demonstrated in both sexes. Adrenal and kidney tissues of stressed mice demonstrated a higher number of necrotic cells than control. The pyknosis phase was more common than the karyorrhexis and karyolitic phases. Interestingly, male mice were more receptive to stress than female mice. These findings indicate that restraint stress leads to behavioral changes and cellular defects in the adrenal glands and kidneys, particularly in male mice. The sympathetic activation and hypothalamus-pituitary-axis stimulation are assumed as the underlying stress effect of the restraint procedure. The restraint stress method has the potential to be used in future research on stress-responsive target organs.
Effectiveness of Hyaluronic Acid Nasal Drops in Post Functional Endoscopic Sinus Surgery
Authors: Yusnita Dian , Dewi Anna Mailasari Kusuma , Hariyati Riece
Published: April 2022

Functional Endoscopic Sinus Surgery (FESS) is commonly performed on patients with chronic rhinosinusitis (CRS) that has not improved through medical treatment. Hyaluronic acid (HA) has a vital role in wound healing and mucosa repair. This study aimed to determine the effectiveness of nasal drops using HA on clinical symptom scores, quality of life, and endoscopic features in post-FESS patients. This study was conducted with a pre- and post-test randomized control group design in 50 CRS patients undergoing FESS (25 males, 25 females, aged 18 to 55 years) at Dr. Kariadi General Hospital Medical Center Semarang from May to November 2019. The treatment group received additional HA therapy, while the control group only received standard therapy. Subjects were assessed with clinical symptom scores, quality of life, and endoscopic features before and after treatment. The statistical analysis was performed between the control and treatment groups using the Mann-Whitney test. There were significant differences between the control and treatment groups on clinical symptom scores (nasal congestion p = 0.001, runny nose p = 0.027) and endoscopic features (edema p = 0.001, secret p = 0.001, crusts p = 0.001). The therapy in post-FESS patients was using nasal drops, the treatment group was given HA, and the control group was given a placebo. Nasal drops using HA in the treatment group show improvement in clinical symptom scores of nasal congestion and runny nose, as well as the endoscopic appearance of edema, secret, and crusts.
Baseline Stroke Severity as a Predictor of 30-Day Post-Ischemic Stroke Disability Outcome
Authors: Teresa Diana , Pinzon Rizaldy Taslim , Adisaputro Sugianto
Published: April 2022

More than 50% of patients who survived stroke have a chronic disability. The National Institute of Health Stroke Scale (NIHSS) is a scoring system to determine the neurologic deficit of a stroke patient. This study analyzed stroke severity based on baseline NIHSS score as a determinant for 30-day post-ischemic stroke disability. This study method uses a retrospective cohort design based on medical records and stroke registry of ischemic stroke patients in Bethesda Hospital Yogyakarta. During admission, the predictive factors for the disability of the study subjects were evaluated. The baseline NIHSS assessment score was measured at 1x24 hours after admission. Disability was measured using a simplified modified Rankin Scale questionnaire (smRSq) Indonesian version at 30-day post-ischemic stroke. Statistical analysis includes univariate, bivariate, and logistic regression multivariate data analysis. The subjects were 84 patients with ischemic stroke. Disability at 30-day post-ischemic stroke occurred in 22 patients (26.2%). Logistic regression multivariate analysis show that Neutrophil to Lymphocyte Ratio (NLR) (RR: 4.488, CI: 1.873–10.756, p: 0.001) and baseline NIHSS score (RR: 28.563, CI: 2.891–282.181, p: 0.004) together significantly affect the mRS of 30-day post-ischemic stroke. Patients admitted with a higher baseline NIHSS score have a 28.5 fold risk for a worse functional outcome than those with lower baseline NIHSS scores. Stroke severity based on baseline NIHSS score is a determinant factor for disability in patients at 30-day post-ischemic stroke.
Sugiyama Layouts for Prescribed Drawing Areas
Authors: Rüegg Ulf
Published: April 2022

The area of graph drawing is concerned with positioning the elements of a graph on a canvas such that the resulting drawing is well-readable by humans and aids their execution of certain tasks.
While known methods are usually well-studied from a theoretical perspective, both their applicability to graphs from practice and their integration into tools from practice are not always satisfactory.
This is due to various reasons, for instance, due to known methods usually solving well-defined, self-contained problems that do not cover all of the bits and pieces that must be considered in practice.
There, the diagrams the graphs originate from often comprise more than just simple nodes and simple edges, they tend to be messy and complex, and existing methods regularly compute drawings with poor compactness.
This thesis is concerned with improving the well-known layer- based layout approach, originally proposed by Sugiyama et al., and devotes special attention to the requirements of data flow diagrams.
It presents new methods for the approach’s layer assignment and coordinate assignment steps, and it identifies and illustrates research tasks that are essential to further better the situation in practice.
Lessening Organ Dysfunction With Vitamin C (LOVIT) Trial: Statistical Analysis Plan
Authors: Adhikari Neill KJ , Pinto Ruxandra , Day Andrew G , Masse Marie-Hélène , Ménard Julie , Sprague Sheila , Annane Djillali , Arabi Yaseen M , Battista Marie-Claude , Cohen Dian , Cook Deborah J , Guyatt Gordon H , Heyland Daren K , Kanji Salmaan , McGuinness Shay P , Parke Rachael L , Tirupakuzhi Vijayaraghavan Bharath Kumar , Charbonney Emmanuel , Chassé Michaël , Del Sorbo Lorenzo , Kutsogiannis Demetrios James , Lauzier François , Leblanc Rémi , Maslove David M , Mehta Sangeeta , Mekontso Dessap Armand , Mele Tina S , Rochwerg Bram , Rewa Oleksa G , Shahin Jason , Twardowski Pawel , Young Paul Jeffrey , Lamontagne François ,   LOVIT Investigators
Published: April 2022

Background

The LOVIT (Lessening Organ Dysfunction with Vitamin C) trial is a blinded multicenter randomized clinical trial comparing high-dose intravenous vitamin C to placebo in patients admitted to the intensive care unit with proven or suspected infection as the main diagnosis and receiving a vasopressor.

Objective

We aim to describe a prespecified statistical analysis plan (SAP) for the LOVIT trial prior to unblinding and locking of the trial database.

Methods

The SAP was designed by the LOVIT principal investigators and statisticians, and approved by the steering committee and coinvestigators. The SAP defines the primary and secondary outcomes, and describes the planned primary, secondary, and subgroup analyses.

Results

The SAP includes a draft participant flow diagram, tables, and planned figures. The primary outcome is a composite of mortality and persistent organ dysfunction (receipt of mechanical ventilation, vasopressors, or new renal replacement therapy) at 28 days, where day 1 is the day of randomization. All analyses will use a frequentist statistical framework. The analysis of the primary outcome will estimate the risk ratio and 95% CI in a generalized linear mixed model with binomial distribution and log link, with site as a random effect. We will perform a secondary analysis adjusting for prespecified baseline clinical variables. Subgroup analyses will include age, sex, frailty, severity of illness, Sepsis-3 definition of septic shock, baseline ascorbic acid level, and COVID-19 status.

Conclusions

We have developed an SAP for the LOVIT trial and will adhere to it in the analysis phase.

International Registered Report Identifier (IRRID)

DERR1-10.2196/36261
Fruit Quality Evaluation in The Maturation Process of Blueberries Using Image Processing
Authors: Zahra Aryanis Mutia , Chosa Tadashi , Tojo Seishu
Published: April 2022

Blueberries' quality does not change uniformly during ripeness. Blueberries should be harvested fully ripened at the post-climacteric stage with an excellent indicator including consistent color, taste, and ease of removal from plant as excellent indicators. Therefore, the blueberries are not harvested until it has the desired blue color. The reliance on human perception on the fruit's taste and appearance might cause inconsistency and inaccurate judgment of the fruit maturation. This study aimed to develop an image processing algorithm capable of classifying blueberry maturity stages. The Bluecrop Northern highbush blueberry was harvested at five different stages of maturity based on visual grading of the fruit color (green, green-red, red, red-blue, and blue) from various fruit positions on the tree. Image processing with discriminant analysis accurately classified maturity stages at 98.3% accuracy. The image quality attributes of blueberries changed significantly at different maturity stages. Overall, most image quality attributes correlated strongly with well-performed blueberry physicochemical properties. This study showed that image processing during the blueberry maturation process could be a reliable and comprehensible method for estimating changes in color, shape, weight, and ultimately changes in specific physicochemical properties. This study also provided a practical evaluation of the maturity stages and physicochemical properties, which were predicted using image processing.
EDUCATORS’ KNOWLEDGE AND STANDPOINTS ON BONE MARROW DONATION
Authors: KARAKOSTA VASILIKI , NIKITIDIS NIKOLAOS
Published: April 2022

Objectives: The objectives of the study are what is the degree of registration of educators, what is the attitude of educators about organ donation, and what are the factors related to the decision to donate.
Methods: It is a quantitative cross-sectional study using a structured questionnaire. A sample consisted of 208 teachers with the greater predominance of women. Logarithmic regression was applied to determine the effect of demographics, knowledge evaluation, and evaluation of views toward the possibility of registration in the body donor register.
Results: Out of the participants, 7.5% are registered in the organ donor and 20.5% are active body donors. One in two wants to become an organ donor. The views evaluation on a scale with a minimum of 23 and a maximum of 115 was 87.58 (9.62). The knowledge evaluation on a scale with a minimum of 0 and a maximum of 6 was 2.17 (1.46). The underlying impression of participants on their knowledge of organ donation on a scale of 1–6 was 3.18 (1.47). The 45–50 age group is 19.9 times more likely to be registered and the evaluation of views increases.
Conclusion: The degree of registration in donor registers (7.5%) is considered low. The assessment of attitudes 87.58 and knowledge 2.17 (1.46) is considered also insufficient. The main source of knowledge is the media. It is necessary to increase the contribution of more reliable sources (academic studies, ministry, and information actions).
ИНТЕЛЛЕКТУАЛЬНАЯ САПР «СМЕКАЛЕЦ»: БЫСТРЫЙ И ПРОСТОЙ СИНТЕЗ СВЧ ИНТЕГРАЛЬНЫХ СХЕМ
Authors: Калентьев А. , Добуш И. , Горяинов А. , Сальников А.
Published: April 2022

В статье представлена САПР «Смекалец», разрабатываемая компанией 50ohm Technologies. ПО ориентировано на автоматический синтез схемотехнических решений и эскизов топологий как монолитных интегральных схем, так и многофункциональных интегральных схем СВЧ-диапазона. САПР «Смекалец» подготавливает схемные решения, учитывая особенности технологических процессов. Приведенные результаты измерений изготовленных образцов монолитных интегральных схем СВЧ-диапазона подтверждают работоспособность предложенных подходов.
50 лет хиральной жидкостной хроматографии: методы, сорбенты, применения
Authors: Яшин А.Я. , Яшин Я.И. , Даванков В.А.
Published: April 2022

Обсуждаются основные достижения хиральной хроматографии за 50 лет: рассмо-
трены методы, в которых реализованы режимы хиральной хроматографии, и эволю-
ция технологий приготовления хиральных сорбентов. Приведены примеры многих
применений хиральной хроматографии от анализа лекарств до диагностики забо-
леваний и процессов старения, фармакокинетики лекарств в медицине, в контроле
качества и безопасности пищевых продуктов, мониторинге загрязнений окружаю-
щей среды, в судебной химии. Отдельно рассмотрены новые применения.
Аккредитация – объективный путь к надежным и достоверным результатам испытаний
Authors: Болдырев И.В.
Published: April 2022

И. В. Болдырев стоял у истоков формирования и развития в России систем аккреди-
тации испытательных лабораторий. Признанный на международном уровне эксперт
по аккредитации, лидерские качества и компетентность которого в качестве управ-
ляющего позволили органу по аккредитации ААЦ «Аналитика» первому в России
получить признание Международного сотрудничества по аккредитации лаборато-
рий – ILAC (International Laboratory Accreditation Cooperation).
Пользуясь возможностью, мы попросили И. В. Болдырева рассказать об истории
аккредитации в России, проблемах, с которыми столкнулись российские испытатель-
ные лаборатории, об актуальных нормативных документах и перспективах междуна-
родного сотрудничества.
Design and Implementation of Smart Energy Meter
Authors: Sharma Prof. C. J. , Bhajbhuje Aparna S. , Tajane Nikita R. , Dharmik Bhavesh V.
Published: April 2022

Abstract: In this paper we are presents the design and implementation of a smart energy meter using an PIC16F886 microcontroller and a liquid crystal display (LCD). It is used in residential consumer. It is an electric device having energy meter chip for measuring the electric energy consumed. It is also allowing the meter owner to have a meter utilized and the corresponding amount will be displayed on the LCD continuously. Also they can monitor the meter reading regularly without the person visiting each house. Microcontroller PIC16F886 to prevent and control the energy meter from power theft. In the voltage system whenever occurring of under voltage and over voltage condition then meter should be given a constant voltage. Keywords: Smart meter, PIC16F886 microcontroller, Power consumption, Voltage stabilizer and LCD display
Fingerprint,Face and Voice Recognition Based Attendance Monitoring System
Authors: Danish Aafreen , Hedau Khushali , Ukey Diksha , Walde Anisha , Sheikh Uzma Sohail , Nagani Prof.Akbar
Published: April 2022

Abstract: In This project aims to record the attendance without manual intervention. In the area of technology that changes and modifies daily, use biometrics is the most popular and trending technology. Taking attendance manually for a class of almost 60-80 students can be a time-consuming task if thought of it in a long run Each person has a unique biometric feature such as fingerprint, face structure, voice detection etc. Keywords— Boimetrics, Fringerprint, Face Structure,Voice Detection.
Review Paper of Pedal Power Washing Machine
Authors: Waghmare Dr. Atul , Sadmal Sahil , Jain Hardik , Sakarde Chetan , Kosare Yogesh , Meshram Prakash , Khandekar Rajat
Published: April 2022

Abstract: Pedal Powered Clothes Washer is a low cost machine made up of easily and readily available scrap parts in daily life. It is a machine which generates power through human pedaling and with the drive mechanism, converts the pedaling motion into required rotary motion of the washing drum. Its innovation lies in its simple design, use of inexpensive parts, very low repairing and maintenance cost, affordability to each member of the society and it does not affect the environment. Our team intends to directly address the problems faced in washing clothes, and thus have developed a new design for easy effort in washing, rinsing and drying clothes. The Pedal Powered Clothes Washer is a completely new concept, which in its one laundry cycle does washing, rinsing and drying of clothes similar to that of an automatic washing machine available in the market.
Acoustic and Viscometric Investigations of Aqueous D-Pantothenic Acid Calcium Hemi-salt
Authors: Kinnake Subhash V.
Published: April 2022

Abstract: Acoustic and viscometric measurements are increasingly being used to investigate the properties of pure components as well as the nature, strength, and order of intermolecular interactions between constituents in solution. The density (ρ), viscosity (n), and ultrasonic velocity (U) of aqueous D-Pantothenic acid hemi-calcium salt at 298.15K and 300.15K were measured. Various thermo -acoustic parameters such as adiabatic compressibility, free length (Lf), free volume (Vf), internal pressure, acoustic impedance (Z), Gibb's free energy (G), and molar sound velocity (R) have been calculated using experimentally measured data. Acoustic parameters are useful in understanding molecular interactions in binary liquid mixtures. Keywords; Ultrasonic velocity, Free length, acoustical parameters, Acoustic impedance.
Automatic Material Filling Machine for IBM
Authors: Parwadi Aniket , Mayekar Shrilesh , Divekar Amol , Ahire Harshal
Published: April 2022

Abstract: Technological advancements are taking place day- by-day and industrial growth has been the key aspect of development of any nation. In plastic injection moulding machine, the provision is to transfer powder raw material from ground to the hopper is not provided or the powder transfer can be done manually in machine. Many small scale industries has moulding machine where they have to fill the raw material at a height where a human efforts are needed which increases the production time rate, leads to increases the wastage of raw materials. Also limited space and hence the system cost increases design of Raw Material feeding mechanism is made as per small scale industries need by considering the above constraints and accordingly. Accordingly theoretical design calculations are made for mini hopper, material volume. Types of raw materials Polyvinylchloride, Polypropylene are selected and testing their total fill time, empty time. Power consumption rate with respect to height in a design of raw material hopper feeding mechanism. Overall, this project involves processes like design, analysis, fabrication and assembling of different components