bluuebunny/crossref_metadata_2025 huggingface dataset:
Petrogenesis of the Eocene Highly Fractionated Granite Porphyry with REE Tetrad Effect: An Example from Western Yunnan, Southeastern Tibetan Plateau
Authors: Yang Hang , Wu Peng , Liu Anlin , Wang Feng
Published: October 2023

Highly fractionated granites are widely distributed in the crust and provide unique windows into magmatic evolution. This study reports petrography, zircon U–Pb ages, trace elemental, and Hf isotopic, as well as whole-rock elemental and Nd isotopic data of highly fractionated granite porphyries from the Shiguanshan area in western Yunnan, southeastern Tibet. The granite porphyries were formed at 34.0 ± 0.3 Ma in a post-collisional setting. They are strongly peraluminous (A/CNK = 1.95–2.80), have high SiO2 content (SiO2 = 78.16–79.13 wt.%) and zircon saturation temperatures (803–829 °C, average 819 °C), and low MgO, with pronounced enrichment in Pb, U, Th, and Rb, and depletion in Ti, Eu, P, Sr, and Ba, and belong to highly fractionated A-type granites. These rocks define linear trends on Harker diagrams and display similar enriched whole-rock Nd isotopic (εNd(t) = −12.8 to −12.3) and zircon Hf isotopic (εHf(t) = −10.4 to −8.8) compositions compared to the published data of coeval mantle-derived syenite porphyries, which can be attributed to fractional crystallization processes. A quantitative model suggests that the Shiguanshan granite porphyries likely formed through the fractionation process of a mineral assemblage consisting of plagioclase, K-feldspar, biotite, and amphibole (in a ratio of 40:30:25:5), with fractionation degrees of 50%–55%. The magmatic textures and zircons, decoupling between the REE tetrad effect and fractionation of twin-elements, along with the modeling result of Rayleigh fractionation, suggest that the REE tetrad effect in the Shiguanshan granite porphyries may be caused by fractionation of accessory minerals. Our data, along with regional observations, propose that the generation of these granite porphyries is possibly related to lithospheric removal following the Indo–Asia collision.
Inorganic Nanoparticles as Radiosensitizers for Cancer Treatment
Authors: Babu Balaashwin , Stoltz Samantha Archer , Mittal Agastya , Pawar Shreya , Kolanthai Elayaraja , Coathup Melanie , Seal Sudipta
Published: October 2023

Nanotechnology has expanded what can be achieved in our approach to cancer treatment. The ability to produce and engineer functional nanoparticle formulations to elicit higher incidences of tumor cell radiolysis has resulted in substantial improvements in cancer cell eradication while also permitting multi-modal biomedical functionalities. These radiosensitive nanomaterials utilize material characteristics, such as radio-blocking/absorbing high-Z atomic number elements, to mediate localized effects from therapeutic irradiation. These materials thereby allow subsequent scattered or emitted radiation to produce direct (e.g., damage to genetic materials) or indirect (e.g., protein oxidation, reactive oxygen species formation) damage to tumor cells. Using nanomaterials that activate under certain physiologic conditions, such as the tumor microenvironment, can selectively target tumor cells. These characteristics, combined with biological interactions that can target the tumor environment, allow for localized radio-sensitization while mitigating damage to healthy cells. This review explores the various nanomaterial formulations utilized in cancer radiosensitivity research. Emphasis on inorganic nanomaterials showcases the specific material characteristics that enable higher incidences of radiation while ensuring localized cancer targeting based on tumor microenvironment activation. The aim of this review is to guide future research in cancer radiosensitization using nanomaterial formulations and to detail common approaches to its treatment, as well as their relations to commonly implemented radiotherapy techniques.
Molecular Characterization of Bacterial Agents Causing External Ocular Infections Isolates of Patients in a Third Level Hospital
Authors: Durán-Manuel Emilio Mariano , Bello-López Juan Manuel , Salinas-Bobadilla Aranza Denisse , Vargas-De-León Cruz , Nieto-Velázquez Nayeli Goreti , Moreno-Eutimio Mario Adán , Pastelin-Palacios Rodolfo , Calzada-Mendoza Claudia Camelia , Blanco-Hernández Dulce Milagros Razo
Published: October 2023

Empirical use of antibiotics in the treatment of eye infections leads to bacterial pathogens becoming resistant to antibiotics; consequently, treatment failure and eye health complications occur. The aim of this study was to describe the phenotype and genotype of the resistance and adherence of bacterial agents causing eye infections in patients at Hospital Juárez de México. An observational, prospective, cross-sectional, and descriptive study was carried out in patients with signs and symptoms of ocular infection. Bacterial agents were isolated and identified by classical microbiology and mass spectrometry. Antibiotic resistance and adherence profiles were determined. Finally, resistance (mecA/SCCmec) and virulence (icaA and icaD) genes were detected in the Gram-positive population. The results showed that blepharitis was the most prevalent condition in the study population. A MALDI-TOF analysis revealed that Staphylococcus and Pseudomonas genus were the most prevalent as causal agents of infection. Resistances to β-lactams were detected of 44 to 100%, followed by clindamycins, aminoglycosides, folate inhibitors, and nitrofurans. A multiple correspondence analysis showed a relationship between mecA genotype and β-lactams resistance. The identification of SCCmecIII and SCCmecIV elements suggested community and hospital sources of infection. Finally, the coexistence of icaA+/icaD+/mecA(SCCmecIII) and icaA+/icaD+/mecA(SCCmecIV) genotypes was detected in S. aureus. The identification of resistant and virulent isolates highlights the importance of developing protocols that address the timely diagnosis of ocular infections. Herein, implications for the failure of antimicrobial therapy in the treatment of ocular infections in susceptible patients are analysed and discussed.
Evidence for Bartonella quintana in Lice Collected from the Clothes of Ethiopian Homeless Individuals
Authors: Tufa Tafese Beyene , Margos Gabriele , Fingerle Volker , Hartberger Christine , Poppert Sven , Birtles Richard J. , Kraiczy Peter , Kempf Volkhard A. J. , Frickmann Hagen , Feldt Torsten
Published: October 2023

Human lice, Pediculus humanus, can transmit various pathogens, including Bartonella quintana, Borrelia recurrentis, and Rickettsia prowazekii. Xenosurveillance is an epidemiological approach to assessing human infection risks performed by screening vectors of infectious disease agents. In the proof-of-principle study reported herein, the DNA of 23 human lice was collected from the clothes of 30 homeless Ethiopian individuals. These samples were assessed using 16S rRNA gene-specific pan-eubacterial PCR for screening, followed by Bartonella genus 16S-23S internal transcribed spacer (ITS) sequence-specific PCR, Bartonella genus gltA gene-specific PCR, and 16S rRNA gene PCR with specificity for relapsing-fever-associated Borrelia spp. with subsequent sequencing of the amplicons. In one sample, the pan-eubacterial 16S rRNA gene-specific screening PCR, the Bartonella genus 16S-23S ITS sequence-specific PCR, and the Bartonella genus gltA gene-specific PCR allowed for the sequencing of B. quintana-specific amplicons. In two additional samples, Bartonella genus gltA gene-specific PCR also provided sequences showing 100% sequence identity with B. quintana. In total, 3/23 (13.0%) of the assessed lice were found to be positive for B. quintana. Correlating clinical data were not available; however, the assessment confirmed the presence of B. quintana in the local louse population and thus an associated infection pressure. Larger-sized cross-sectional studies seem advisable to more reliably quantify the infection risk of lice-infested local individuals. The need for prevention by providing opportunities to maintain standard hygiene for Ethiopian homeless individuals is stressed by the reported findings, especially in light of the ongoing migration of refugees.
Transcriptional Targeting Approaches in Cardiac Gene Transfer Using AAV Vectors
Authors: Schröder Lena C. , Frank Derk , Müller Oliver J.
Published: October 2023

Cardiac-targeted transgene delivery offers new treatment opportunities for cardiovascular diseases, which massively contribute to global mortality. Restricted gene transfer to cardiac tissue might protect extracardiac organs from potential side-effects. This could be mediated by using cis-regulatory elements, including promoters and enhancers that act on the transcriptional level. Here, we discuss examples of tissue-specific promoters for targeted transcription in myocytes, cardiomyocytes, and chamber-specific cardiomyocytes. Some promotors are induced at pathological states, suggesting a potential use as “induction-by-disease switches” in gene therapy. Recent developments have resulted in the identification of novel enhancer-elements that could further pave the way for future refinement of transcriptional targeting, for example, into the cardiac conduction system.
OsCIPK9 Interacts with OsSOS3 and Affects Salt-Related Transport to Improve Salt Tolerance
Authors: Zhou Zhenling , Tang Weijie , Sun Zhiguang , Li Jingfang , Yang Bo , Liu Yan , Wang Baoxiang , Xu Dayong , Yang Jianchang , Zhang Yunhui
Published: October 2023

Salt is harmful to crop production. Therefore, it is important to understand the mechanism of salt tolerance in rice. CIPK genes have various functions, including regulating salt tolerance and other types of stress and nitrogen use efficiency. In rice, OsCIPK24 is known to regulate salt tolerance, but other OsCIPKs could also function in salt tolerance. In this study, we identified another OsCIPK—OsCIPK9—that can regulate salt tolerance. Knockout of OsCIPK9 in rice could improve salt tolerance. Through expression analyses, OsCIPK9 was found to be mainly expressed in the roots and less expressed in mature leaves. Meanwhile, OsCIPK9 had the highest expression 6 h after salt treatment. In addition, we proved the interaction between OsCIPK9 and OsSOS3. The RNA-seq data showed that OsCIPK9 strongly responded to salt treatment, and the transporters related to salt tolerance may be downstream genes of OsCIPK9. Finally, haplotype analyses revealed that Hap6 and Hap8 mainly exist in indica, potentially providing a higher salt tolerance. Overall, a negative regulator of salt tolerance, OsCIPK9, which interacted with OsSOS3 similarly to OsCIPK24 and influenced salt-related transporters, was identified, and editing OsCIPK9 potentially could be helpful for breeding salt-tolerant rice.
Selection of Flax Genotypes for Pan-Genomic Studies by Sequencing Tagmentation-Based Transcriptome Libraries
Authors: Pushkova Elena N. , Borkhert Elena V. , Novakovskiy Roman O. , Dvorianinova Ekaterina M. , Rozhmina Tatiana A. , Zhuchenko Alexander A. , Zhernova Daiana A. , Turba Anastasia A. , Yablokov Arthur G. , Sigova Elizaveta A. , Krasnov George S. , Bolsheva Nadezhda L. , Melnikova Nataliya V. , Dmitriev Alexey A.
Published: October 2023

Flax (Linum usitatissimum L.) products are used in the food, pharmaceutical, textile, polymer, medical, and other industries. The creation of a pan-genome will be an important advance in flax research and breeding. The selection of flax genotypes that sufficiently cover the species diversity is a crucial step for the pan-genomic study. For this purpose, we have adapted a method based on Illumina sequencing of transcriptome libraries prepared using the Tn5 transposase (tagmentase). This approach reduces the cost of sample preparation compared to commercial kits and allows the generation of a large number of cDNA libraries in a short time. RNA-seq data were obtained for 192 flax plants (3–6 individual plants from 44 flax accessions of different morphology and geographical origin). Evaluation of the genetic relationship between flax plants based on the sequencing data revealed incorrect species identification for five accessions. Therefore, these accessions were excluded from the sample set for the pan-genomic study. For the remaining samples, typical genotypes were selected to provide the most comprehensive genetic diversity of flax for pan-genome construction. Thus, high-throughput sequencing of tagmentation-based transcriptome libraries showed high efficiency in assessing the genetic relationship of flax samples and allowed us to select genotypes for the flax pan-genomic analysis.
Insecticidal Activity of Selected Essential Oils against Drosophila suzukii (Diptera: Drosophilidae)
Authors: Bošković Dragana , Vuković Slavica , Lazić Sanja , Baser Nuray , Čulum Dušan , Tekić Dragana , Žunić Antonije , Šušnjar Aleksandra , Šunjka Dragana
Published: October 2023

The spotted wing drosophila (SWD), Drosophila suzukii Matsumura (Diptera: Drosophilidae), is an invasive polyphagous pest of soft-skinned fruit that has started to threaten small fruit production in Europe since 2008. High reproductive capacity, short generation time, and difficulties in visualizing early damage contribute to its rapid spread. Currently, the control strategy against D. suzukii mostly relies on treatment with synthetic insecticides. Keeping in mind that this pest causes the greatest damage during the harvesting period, control using chemicals is not recommended due to the increased risk of high pesticide residue levels in the fruit. With the aim of reducing the use of insecticides, there is a need for developing an environmentally safer way of control. Alternative solutions could rely on the use of essential oils (EOs), which can be used in conventional and organic production systems. Four essential oils, geranium (Pelargonium graveolens), dill (Anethum graveolens), Scots pine (Pinus sylvestris), and bergamot (Citrus bergamia), were assessed for their insecticidal effects using four different tests (contact toxicity, fumigant-contact toxicity, repellent effect, and multiple-choice tests). The EOs applied were dissolved in acetone at three different concentrations. The most promising one was the geranium essential oil, which had the best effect in all conducted tests, even at the lowest applied concentration. Geranium oil caused very high mortality (95%), even at the lowest concentration applied, after 24 h in the fumigant-contact test, and it caused a mortality of over 85% in the contact test. It was also noticed that geranium demonstrated a deterrent effect by repelling females from laying eggs for four days after at the lowest applied concentration. Scots pine and dill EOs have moderate to strong effects in most tests. The mortality of 100% was achieved for the highest applied concentration in the fumigant-contact and contact tests. Bergamot EO did not have any significant insecticidal activity. Geranium, Scots pine, and dill have great potential to be used as an environmentally friendly way of controlling D. suzukii as they exhibit deterrent, repellent, and insecticidal effects.
Fast-Frequency-Response Control Method for Electrode Boilers Supporting New Energy Accommodation
Authors: Shi Tao , Chen Zhiqiang , Guo Shufeng , Li Dan
Published: October 2023

With the large-scale integration of new energy generation, represented by wind and photovoltaic power, into the power grid, the intermittency, randomness, and fluctuations of their output pose significant challenges to the safe and stable operation of the power system. Therefore, this paper proposes a control method for electrode boiler systems participating in rapid grid frequency response based on a fuzzy control strategy. This method improves the traditional electrode boiler control strategy, giving it characteristics similar to those of synchronous generators in terms of active power–frequency droop, allowing it to actively adjust active power based on system frequency disturbances. Furthermore, it optimizes its control performance indicators using fuzzy algorithms. The simulation results on the Matlab/Simulink platform demonstrate that the modified electrode boiler control system, when applying this method, can effectively address power disturbances in the system, reduce system frequency deviations, and contribute to enhancing the grid frequency regulation capability and system stability.
Optimal Design of Motor–Pump Parameters for Direct Load-Sensitive EHA Based on Multi-Objective Optimization Algorithm
Authors: Li Yanpeng , Kang Hongpu , Li Mingzhong , Zhang Jinhu , Han Huijun , Yu Tian , Hu Shaoping
Published: October 2023

The electro-hydrostatic actuator (EHA) is a highly integrated and reliable actuation system which has been widely used in aerospace and construction machinery. In addition, the direct load sensitive EHA (DLS–EHA) has been investigated by introducing load-sensitive techniques which can well match the system output and external loads. More importantly, the matching design of motor–pump parameters is an important stage in the pre-design phase of DLS–EHA. For this reason, a multi-objective optimization design method for DLS–EHA motor–pump parameters is proposed in this paper. Firstly, the motor–pump mass and energy loss models are constructed based on similarity criteria. Secondly, the multi-objective particle swarm optimization algorithm (MOPSO) is used to optimize the design of the motor-pump parameters, and the Pareto frontier solutions of the optimized parameters are obtained. Further, the optimal design parameters are selected on the basis of meeting the actual requirements. Finally, the DLS–EHA prototype is designed based on the optimized design parameters and experimental verification is completed. The results of the study show that the optimized design parameters can meet the design requirements. The design method proposed in this paper provides an important theoretical basis for the optimized design of DLS–EHA.
Searching for the Location of Lord Lao: The Evolution of Daoist Cosmic Concept between the Han and Tang Dynasties
Authors: Bai Zhaojie , Li Pei
Published: October 2023

The period between the Han and Tang dynasties was a crucial time in the development of the Daoist cosmic concept. During that time, Daoist believers needed to place important deities properly in the newly created heavenly realm. Faced with placing the great deity Lord Lao in a specific place, different Daoist believers made various attempts with some complex adjustments, which eventually reached the consensus during the Tang Dynasty at the latest that “Lord Lao lives in Great Clarity Heaven”. The investigation of this adjustment process would present multiple possibilities in the development of the Daoist cosmic concept.
The Dynamic Endogeneity Issue between Corporate Ownership Structure and Real-Based Earnings Manipulation in an Emerging Market: Advanced Dynamic Panel Model
Authors: Attia Eman Fathi , Mehafdi Messaoud
Published: October 2023

This study aims to contribute to the existing literature by examining the relationship between corporate governance (CG) attributes and real-based earnings management (REM) in the context of an emerging market economy. The study employs a sample of 78 Egyptian Exchange (EGX)-listed companies covering the period from 2008 to 2017, yielding a total of 780 observations. To address dynamic endogeneity concerns between CG mechanisms and REM, the dynamic panel system-generalized method of moments (SGMM) estimator is used as the main analytical tool. The findings reveal that managerial and family ownership are negatively and significantly correlated with REM proxies, except for the ABCFO measure. By contrast, government and institutional ownership exhibit contrasting results, depending on the REM proxies used. The CG-EM relationship is influenced by several conflicting theoretical perspectives, including agency theory, institutional theory, stewardship theory, and resource dependence theory, resulting in inconsistent empirical findings. To the best of the authors’ knowledge, this study is the first to detect Real-earnings manipulation practices (REM) in the Egyptian context using six models to confirm the validity, reliability, and robustness of the findings. Additionally, the study employs an advanced statistical technique that considers endogeneity, heteroscedasticity, and simultaneity in the relationship between CG mechanisms and earnings quality. The results highlight the importance of considering the institutional and legal context of a country when analyzing the impact of corporate governance mechanisms on earnings quality, as the practice and implementation of governance mechanisms vary across countries.
Comparative Analysis of the Journalistic Agenda between Corporate and Community Media in Ecuador National Strike 2022
Authors: Cuzco-Gallegos Franklin Gabriel , Vanegas-Toala Yadis Vanessa
Published: October 2023

This article presents a comparative analysis of the journalistic coverage of the Ecuador social mobilizations of June 2022. It takes as case studies the corporate media Ecuavisa, with 215 news of the stellar newscast Televistazo, and the community media Televisión del Movimiento Indígena de Cotopaxi (TV MICC), with 437 publications on its Facebook page. Based on the Critical Discourse Analysis, we investigate the media disputes of meaning and power in the journalistic agenda and framing, from which the legitimization and delegitimization of the protest were configured. Among the main results, Ecuavisa focused its news agenda on the defense of governmental actions and the support to the productive business sector, generating a frame of support for the actions of the public forces in defense of democracy, while TV MICC, in a practice of communicational sovereignty, generated journalistic coverage vindicating the political agenda of the mobilization led by the Indigenous Movement. Additionally, it made visible the multiple violations of human and cultural rights carried out by the public force within the framework of a racist culture.
Factors Influencing Post-COVID-19 Virtual Education and Its Impact on University Students: Analysis Using Structural Equation Models
Authors: Valdés Hernández Roberto Carlos , Zazueta Lizeth Armenta , López Hernández Juan Gabriel , Ortega Vidblain Amaro
Published: October 2023

The transcendence of the COVID-19 pandemic in education has transformed the way students use information and communication technologies (ICT) to take virtual classes since the closure of universities, so this research aims to describe how students in the School of Administrative Sciences at the Autonomous University of Baja California use ICT in times of COVID-19 to take their classes. The results obtained show that ICT management directly and indirectly influences students’ collaborative work, and in a direct way, the responsible use of ICT in the teaching–learning process. It also includes a construct validation of the ICT factor in the teaching–learning process and COVID-19 by means of confirmatory factor analysis (CFA), an analysis procedure in structural equation modeling (SEM).
Systematic Review of Agent-Based and System Dynamics Models for Social-Ecological System Case Studies
Authors: Nugroho Supradianto , Uehara Takuro
Published: October 2023

Social–ecological system (SES) modeling involves developing and/or applying models to investigate complex problems arising from the interactions between humans and natural systems. Among the different types, agent-based models (ABM) and system dynamics (SD) are prominent approaches in SES modeling. However, few SES models influence decision-making support and policymaking. The objectives of this study were to explore the application of ABM and SD in SES studies through a systematic review of published real-world case studies and determine the extent to which existing SES models inform policymaking processes. We identified 35 case studies using ABM, SD, or a hybrid of the two and found that each modeling approach shared commonalities that collectively contributed to the policymaking process, offering a comprehensive understanding of the intricate dynamics within SES, facilitating scenario exploration and policy testing, and fostering effective communication and stakeholder engagement. This study also suggests several improvements to chart a more effective trajectory for research in this field, including fostering interdisciplinary collaboration, developing hybrid models, adopting transparent model reporting, and implementing machine-learning algorithms.
Assessment of Genotoxicity of Zinc Oxide Nanoparticles Using Mosquito as Test Model
Authors: Ahluwalia Kanwaljit Kaur , Thakur Kritika , Ahluwalia Amrik Singh , Hashem Abeer , Avila-Quezada Graciela Dolores , Abd_Allah Elsayed Fathi , Thakur Neelam
Published: October 2023

The widespread applications of ZnO NPs in the different areas of science, technology, medicine, agriculture, and commercial products have led to increased chances of their release into the environment. This created a growing public concern about the toxicological and environmental effects of the nanoparticles. The impact of these NPs on the genetic materials of living organisms is documented in some cultured cells and plants, but there are only a few studies regarding this aspect in animals. In view of this, the present work regarding the assessment of the genotoxicity of zinc oxide nanoparticles using the mosquito Culex quinquefaciatus has been taken up. Statistically significant chromosomal aberrations over the control are recorded after the exposure of the fourth instar larvae to a dose of less than LD20 for 24 h. In order to select this dose, LD20 of ZnO NPs for the mosquito is determined by Probit analysis. Lacto-aceto-orcein stained chromosomal preparations are made from gonads of adult treated and control mosquitoes. Both structural aberrations, such as chromosomal breaks, fragments, translocations, and terminal fusions, resulting in the formation of rings and clumped chromosomes, and numerical ones, including hypo- and hyper-aneuploidy at metaphases, bridges, and laggards at the anaphase stage are observed. The percentage frequency of abnormalities in the shape of sperm heads is also found to be statistically significant over the controls. Besides this, zinc oxide nanoparticles are also found to affect the reproductive potential and embryo development as egg rafts obtained from the genetic crosses of ZnO nanoparticle-treated virgin females and normal males are small in size with a far smaller number of eggs per raft. The percentage frequencies of dominant lethal mutations indicated by the frequency of unhatched eggs are also statistically significant (p < 0.05) over the control. The induction of abnormalities in all of the three short-term assays studied during the present piece of work indicates the genotoxic potential of ZnO NPs, which cannot be labeled absolutely safe, and this study pinpoints the need to develop strategies for the protection of the environment and living organisms thriving in it.
Torquetenovirus Loads in Peripheral Blood Predict Both the Humoral and Cell-Mediated Responses to SARS-CoV-2 Elicited by the mRNA Vaccine in Liver Transplant Recipients
Authors: Minosse Claudia , Matusali Giulia , Meschi Silvia , Grassi Germana , Francalancia Massimo , D’Offizi Gianpiero , Spezia Pietro Giorgio , Garbuglia Anna Rosa , Montalbano Marzia , Focosi Daniele , Girardi Enrico , Vaia Francesco , Ettorre Giuseppe Maria , Maggi Fabrizio
Published: October 2023

Three years into the COVID-19 pandemic, mass vaccination campaigns have largely controlled the disease burden but have not prevented virus circulation. Unfortunately, many immunocompromised patients have failed to mount protective immune responses after repeated vaccinations, and liver transplant recipients are no exception. Across different solid organ transplant populations, the plasma levels of Torquetenovirus (TTV), an orphan and ubiquitous human virus under control of the immune system, have been shown to predict the antibody response after COVID-19 vaccinations. We show here a single-institution experience with TTV viremia in 134 liver transplant recipients at their first or third dose. We found that TTV viremia before the first and third vaccine doses predicts serum anti-SARS-CoV-2 Spike receptor-binding domain (RBD) IgG levels measured 2–4 weeks after the second or third dose. Pre-vaccine TTV loads were also associated with peripheral blood anti-SARS-CoV-2 cell-mediated immunity but not with serum SARS-CoV-2 neutralizing antibody titers.
Vaccine Hesitancy among Healthcare Workers in Europe: A Systematic Review
Authors: Kaur Mandeep , Coppeta Luca , Olesen Ole F.
Published: October 2023

This study analyzes vaccine hesitancy (VH) among healthcare workers (HCWs) in 15 European countries. We have undertaken a systematic review by synthesizing data from 46 articles (between 2015 and 2022) encompassing 55,612 subjects. Despite the heterogeneity of the methods in the various studies, we found that physicians had consistently higher vaccination rates than nurses across different countries and different vaccines. Physicians’ average vaccination rate was 79% across a selection of vaccines, while that of nurses was 62%. Concerns regarding vaccine safety, information gaps, and the responsibility of healthcare authorities in managing VH are highlighted by qualitative insights. This research contributes to our comprehension of the ways in which VH among HCWs is impacted by healthcare roles, vaccine types, and regional disparities. The insights gleaned from this analysis can serve as a guide for targeted interventions aimed at increasing vaccine acceptance and coverage in Europe, ultimately strengthening public health.
Opinions, Attitudes and Factors Related to SARS-CoV-2 Vaccine Uptake in Eight South American Countries
Authors: Urueña Analía , Machado Ricardo , Cunha Juarez , López Colmano Clara , Rancaño Carolina , Kfouri Renato , Pírez Catalina , Bonvehí Pablo , Calvo Mario , Cuadros Robinson , Muñoz Greta , Rodríguez Mónica , Torres Jaime , Cahn Florencia , Ballalai Isabella
Published: October 2023

This article presents attitudes and practices regarding COVID-19 vaccination in the South American population. The study collected data from a self-administered survey distributed through social media platforms between February and April 2022 (N = 6555). The survey included questions related to participants’ sociodemographic background, flu vaccination practices, sources of information about COVID-19, and opinions regarding pandemic management and vaccination against SARS-CoV-2. The respondents agreed with the statement that COVID-19 vaccines were necessary (86.4%), effective (79.8%), safe (79.1%), and should be mandatory (64%). Overall, 83.4% accepted vaccination and 12.3% refused it completely. Main rejection reasons were safety (65.8%) and efficacy (54.9%) issues, and rushed development and approvals (49.1%). Vaccine uptake was associated with being ≥60 years, being a healthcare worker, previous influenza vaccine uptake, adherence to preventive measures, the death of ≥1 close people from COVID-19, and being informed through mass media or health authorities’ channels. Vaccine uptake inversely correlated with male gender, low educational level, and use of closed social networks for COVID-19 information purposes. This study provides valuable insights into COVID-19 vaccination attitudes and practices in South America that may be used to promote vaccine uptake in the region. Higher COVID-19 vaccination acceptance among people with previously acquired prevention habits reinforces the importance of routine health promotion strategies.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KECEMASAN PASIEN PADA TINDAKAN PENCABUTAN GIGI
Authors: Widyastuti Tri , Khoirunnisa Nani Mira , Putri Megananda Hiranya , Ningrum Nining
Published: October 2023

Kecemasan adalah reaksi normal manusia yang sudah tampak sejak masa anak-anak. Salah satu hal yang sering membuat anak cemas adalah pergi ke dokter gigi, terutama saat gigi harus melakukan perawatan pencabutan gigi. Bagi terapis gigi dan mulut serta dokter gigi, kecemasan terhadap perawatan gigi merupakan suatu tantangan dalam melakukan pelayanan kesehatan gigi dan mulut, khususnya pada pasien anak. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang berhubungan dengan kecemasan pasien saat pencabutan gigi di klinik utama Yayasan Kesehatan Gigi Anak Indonesia. Jenis metodologi pada penelitian ini ialah penelitian deskriptif dengan menggunakan pendekatan observasional. Jumlah sampel sebanyak 19 orang, pengambilan sampel dengan menggunakan teknik Aksidental Sampling. Peneliti mengumpulkan data secara langsung pada sampel, dengan bantuan enumerator, dan kemudian menampilkannya dalam tabel distribusi frekuensi. Hasil penelitian pada anak-anak mayoritas menunjukkan rasa cemas pada facial image scale pada wajah datar pada saat sebelum dilakukan pencabutan gigi. Wajah datar ditandai dengan perasaan agak tidak senang yang ditunjukkan dengan sudut-sudut mulut yang menunjukkan indikator ketidakpuasan sedang. Faktor yang menyebabkan kecemasan mayoritas disebabkan oleh faktor ketakutan/phobia terhadap alat perawatan gigi sebanyak 17 responden (89,5%). Faktor yang menyebabkan kecemasan terbanyak kedua ialah faktor keluarga dan teman yaitu sebanyak  10 responden (52,6%). Faktor yang menyebabkan kecemasan paling sedikit ialah faktor pengalaman traumatik  yaitu sebanyak 2 responden (10,5%). Untuk mengurangi kecemasan perawatan gigi pada anak dapat menggunakan teknik tell-show-do dan penggunaan aroma terapi.
New Combinations and New Names in Desmopsis (Annonaceae)
Authors: Schatz George E. , Ortiz-Rodriguez Andrés Ernesto , Martínez-Velarde María Fernanda , Couvreur Thomas L. P.
Published: October 2023

Recent studies have suggested that the closely related Neotropical genera Desmopsis Saff. and Stenanona Standl. (Annonaceae) are non-monophyletic and would be better considered as a single genus Desmopsis. The transfer of species currently circumscribed in Stenanona necessitates 14 new combinations and two new names in Desmopsis.
Konsep Etika Sosial dalam Pandangan Ketuhanan Jean-Luc Marion di Era Postmodern
Authors: Manusiwa Rudolfo Jacob , Ludji Irene , Lattu Izak Y. M.
Published: October 2023

This research delves explicitly into and elaborates on the concept of social ethics through the eyes of Jean-Luc Marion's concept of divinity. Through this research, the author understood the contribution of Marion's theory regarding the human face as an icon in social lives during the postmodern era. In order to get the results from the research, a qualitative approach to the literature study was used. The results show that Marion's ideas complete the concept of social ethics characteristics, which can formulate ethics. Marion offers to live icon relations and reject idol relations in social lives because icon relations are relevant for eliminating truth claims (God) within the framework of displaying the character of religious adherents that are inclusive, hospitable, and constructive actions appreciative of each of the characteristics of the various definitions and concepts of divinity. Icon relations live the values of inclusiveness, accepting and being open to plural truth (definition and concept of God), and viewing truth as relative. Furthermore, Marion's understanding of human relations with humans speaks phenomenologically and is normative. Human relations refer to individual awareness that the responses in living together are ethical orders that speak through faces (icon), and the context of agape is also present. Ethical orders and agape will always burden the individual when every time he is faced with the face (icon) of another being.
Apakah Milbank Keliru?: Tinjauan atas Polemik John Milbank dan Teolog Scotist Kontemporer Perihal Doktrin Univocity
Authors: Lumbanbatu Kornelius Andrian R.
Published: October 2023

Artikel ini menganalisis doktrin univocity dalam polemik teologis antara John Milbank dan teolog-teolog Scotist kontemporer. Di dalamnya, penulis mengusung pernyataan tesis bahwa kekeliruan Milbank dalam memahami doktrin univocity secara paradoksal membuktikan validitas argumennya. Penulis mempertanggungjawabkan pernyataan tesisnya dengan memberikan penjelasan bercabang tiga. Masing-masing bagian berfokus pada argumen Milbank terhadap John Duns Scotus, kritik teolog-teolog Scotist kontemporer terhadap Milbank, dan alasan-alasan yang mengindikasikan sifat paradoksal dari argumen Milbank.
Exploring Belief Values in Batu Umang Folklore: A Cultural Analysis of Durin Tani Village, Sibolangit District, Deli Serdang Regency
Authors: Situmorang Sarma , Sinaga Dewi Sartika , Simbolon Soter
Published: October 2023

This research delves into the belief values embedded in the Batu Umang folklore of Durin Tani Village, located in the Sibolangit District of Deli Serdang Regency, North Sumatra, Indonesia. Through a comprehensive and multidisciplinary approach, the study uncovers the intricate web of cultural, social, and historical factors that have shaped these belief values, shedding light on their origins, evolution, and contemporary significance. The cultural context of the Batak people in Durin Tani Village plays a central role in the development of these belief values, with a deep reverence for nature and a harmonious relationship with the environment at its core. Social dynamics, including close-knit community bonds and shared values of unity and collective responsibility, have reinforced these belief values, fostering a sense of community cohesion. The historical backdrop of Dutch colonialism, trade, and migration has left an indelible mark on the folklore, imbuing it with stories of resilience and adaptability in the face of historical challenges. This research contributes significantly to the fields of folklore and cultural anthropology, highlighting the preservation of cultural heritage, community cohesion, and the adaptability of cultural traditions. It also underscores the universal nature of storytelling and belief systems, providing insights into the interconnectedness of culture, society, and history in shaping the belief values of a unique community. Ultimately, this study celebrates the enduring spirit of Durin Tani Village and its timeless cultural heritage, offering a deeper understanding of how local narratives can provide insights into the universal human experience.
Exploring the Influence of Diction and Language Style in Children's Song Lyrics on Preschool Learning and Development
Authors: Hartnett Aron Coffey , Lasslo Sanner Kenrick , Hertlein Beach Reynolds
Published: October 2023

This research delves into the profound influence of diction and language style within children's song lyrics on the educational experiences of preschoolers. The study investigates the impact of diverse language styles, ranging from simpler, repetitive structures to more complex and varied compositions, on language development, cognitive engagement, emotional responses, and learning outcomes in young children. Through a mixed-methods approach encompassing quantitative analysis and qualitative observations, the research examines the implications of varied language styles on comprehension, engagement, and cognitive growth among preschoolers. Findings highlight the significance of diverse language styles in fostering comprehensive learning experiences, nurturing cognitive engagement, emotional responses, and social interactions among preschoolers. The research underscores the importance of a balanced approach to language styles in educational materials, offering immediate engagement while stimulating cognitive challenge for sustained educational growth. The practical application of these findings advocates for educators to curate a diverse repertoire of song lyrics, integrate multisensory experiences, and harness technology to enhance the learning environment for preschoolers, nurturing their language skills, cognitive abilities, and emotional development. The study's implications extend to educational practices, emphasizing the importance of embracing diverse language styles to create a dynamic and comprehensive educational journey for our youngest learners.
Screening of Lipid Production Capacities of Bacillus sp. Strains Isolated from Soil and Lipid Staining with Different Staining Techniques
Authors: DEMİRKAN Elif , YILDIRIM İrem
Published: October 2023

Microbial lipids have been attracting more and more attention in recent years as promising raw

materials for the production of biodiesel and value-added compounds. In the current economic and

environmental situation, finding new renewable sources of lipids will be crucial. Recent research has

necessitated the search for new efficient microbial producers with lipid production efficiency. For this

purpose,50 Bacillus sp. strains previously isolated from the soil were screened for their lipid production

capacity. As a result of the production using a single-cell oil production medium, only two Bacillus spp.

strains showed growth. These bacteria were named as Bacillus sp. E40 and Bacillus sp. E226. Bacteria

were then characterized in terms of their biomass, lipid yields, and lipid contents. The biomass of

Bacillus sp. E40 and E226 bacterial isolates, were 0,28 and 0,22 g.L-1, respectively. The highest lipid

content was reached by E226 with 54.5%. Bacillus sp. E40 lipid content was determined as 46.4%. In

addition, both intracellular lipid staining and colony staining demonstrated the presence of lipids. With

this study, it was reported for the first time that local Bacillus sp. strains isolated from soil have lipid

producing capacity.
Sivaslı (Uşak) Yöresi Mermerlerinin Mühendislik Özelliklerinin Araştırılması
Authors: ÇELİK Haluk , ALPEREN Ayşe Nur , BAĞCI Metin
Published: October 2023

Uşak ve çevresinde yer alan Menderes Masifinde bulunan metamorfik birimlerde Karahallı, Ulubey ve

Sivaslı ilçelerinde önemli mermer potansiyeli bulunmaktadır. Menderes Masifinde yer alan metamorfik

birimler çekirdek ve örtü birimlerden oluşmaktadır. Gnayslar çekirdek birimleri, Şist ve mermerler ise

örtü birimleri oluşturmaktadır. Masifin en yaşlı kayaçlarını oluşturan gnayslar genellikle gözlü ve bantlı

gnayslar şeklinde görülmektedirler. Şistler ise bölgede çok geniş bir alanda bulunmaktadır. Genellikle

şist ve mermerler yer yer birbirleriyle geçişli seviyeler göstermektedir. Bu çalışmada; Sivaslı İlçesinde

işletilmekte olan üç mermer ocağından alınan mermer numunelerinin fiziksel, mekanik, kimyasal,

mineralojik ve petrografik analizleri gerçekleştirilmiştir. Numunelerin fiziksel özelliklerden olan birim

hacim ağırlık değerlerinin 2.69 ile 2.80 gr/cm3 arasında olduğu, ağırlıkça su emme oranlarının %0.17

0.32 arasında değiştiği, doluluk oranı değerlerinin ise %94.04-97.63 arasında değişim gösterdiği

belirlenmiştir. Sivaslı (Uşak) mermerlerinin mekanik özelliklerden olan tek eksenli basınç dayanımı

değerlerinin 919.9-1051.1 kg/cm2 arasında, hacimce sürtünme ile aşınma dayanımı değerlerinin ise 3.90

ile 4.67 cm3/50cm2 arasında olduğu görülmüştür. Mineralojik-petrografik incelemeler neticesinde

Sivaslı mermerlerinin CaO oranlarının %50.6-53.7 arasında değişim gösterdiği numunelerin granoblastik

doku gösteren kalsit mineralleri ve daha az oranda dolomit mineralleri içerdikleri ve tane boyut

dağılımlarına göre kalsit kristallerinin 68.8 µm ile 963.1 µm arasında tane boyutlarının değiştiği tespit

edilmiştir.
Hacılar Ocağı Kireçtaşının Jeolojisi, Petrografik ve Jeokimyasal Özellikleri (Batı Toroslar, Burdur)
Authors: CENGİZ Oya , EĞİN KARACA Yeliz , KIRAY Didem
Published: October 2023

İnceleme alanı, Batı Toroslar’da Isparta Büklümünün batı kanadı üzerinde Hacılar Köyünde (Burdur) yer

alır. Bu çalışmanın amacı, Hacılar Ocağı’ndaki Orta-Triyas-Liyas yaşlı kireçtaşının jeolojisini, mineralojik

petrografik ve jeokimyasal özelliklerini incelemektir. Kireçtaşı beyazımsı-açık-koyu gri ve bej renkli, yer

yer koyu renge sahip dolomitli seviyeler ile açık kırmızı, pembe renkli silisli kireçtaşı düzeyleri kapsar.

Genellikle masif görünümlü olan kireçtaşı Burdur fay zonu üzerinde yer aldığı için yoğun kırık ve

çatlaklara sahiptir. Hacılar bej kireçtaşı mikritik doku, yer yer sparlaşmış, oolitik yapı gösterir. Ayrıca,

kireçtaşı içerisindeki kırıkları ve erime boşluklarını dolduran kolloform ve ışınsal yapılı aragonit-kalsit,

tarak yapılı kuvars, breşik kalsit ve özşekilli dolomit kristallerine de rastlanır. Hacılar kireçtaşı petrografik

sınıflamada, vaketaşı ya da yer yer pelmikritik dokulu dolomitik kireçtaşıdır. Kireçtaşı numunelerinin

CaO ve MgO içerikleri sırasıyla % 37.36-55.74 ve % 0.43-15.45 arasındadır ve yüksek MgO değerleri

dolomit mineralinden gelir. Na2O ve K2O değerlerinin Al2O3 oranlarına ait ve MgO-CaO-Al2O3 üçlü

diyagramlara göre Hacılar kireçtaşı sedimanter kökenlidir. (Mg/Ca)-SiO2 ve Sr-(Mg/Ca) karbonat

ayırtman diyagramlarında numuneler çoğunlukla kireçtaşı, daha az dolomitik kayaç-kireçtaşı geçiş

alanında gözlenir. Bunun yanında, Ca/Mg diyagramında tüm numuneler dolomitik kayaç-kireçtaşı geçiş

zonuna düşerken, MgO/CaO ve SiO2+(Al,Fe)2O3 diyagramında çoğunlukla kireçtaşı, daha az dolomitik

kireçtaşı ve kalsitik kireçtaşı sınıfındadır. Rb-Sr-Ba üçlü ve Sr/Ba-Sr/Rb oranları diyagramları, Hacılar

kireçtaşının kıta kenarları ortamında oluştuğunu gösterir.
A Dispersive Liquid-Liquid Micro Extraction-Gas Chromatography-Mass Spectrometric Method for The Determination of 4-Nonylphenol in Water Samples
Authors: DENİZ Sabahattin
Published: October 2023

In this study an environmentally-friendly, uncomplicated, and responsive method involving dispersive

liquid-liquid microextraction (DLLME) was presented for the isolation and analysis of 4-nonylphenol in

aquatic environments. The extraction process employed the undecanol–water dispersive liquid-liquid

system to isolate 4-nonylphenol. Essential variables impacting the efficiency of microextraction, such

as the quantities of 1-undecanol and acetonitrile, as well as the ionic strength of the aqueous solution,

were fine-tuned. Furthermore, the chromatographic parameters of the Gas Chromatography-Mass

Spectrometer (GC-MS) were optimized for precise analysis, and the analysis of 4-nonylphenol was

conducted using a linear calibration curve spanning 2-1000 µg/L, achieving a rapid 6-minute retention

time. The method exhibited a detection limit of 0.05 µg/L and a preconcentration factor of 188. Analyte

recovery rates ranged from 96% to 103%, having a relative standard deviation below 3%.The applied

procedure was effectively evaluated for its suitability in examining tap water and river water samples.
Infancias que importan: políticas culturales, heterosexualidad y teatro para «niños»
Authors:   , Casella Germán Andrés
Published: October 2023

Propongo generar una trama de reflexiones y problematizaciones alrededor de los procesos de selección de obras de teatro para las infancias, a partir de entender a los mismos como dispositivos de significación que vuelven obligatoria a la heterosexualidad. Para eso, tomo como material de análisis las políticas culturales del Centro Cultural Pasaje Dardo Rocha de la Ciudad de La Plata (Buenos Aires, Argentina), entre los años 2010 y 2020. Así, sostengo que son las maneras de elegir las que sedimentan normativas de género y sexo al conformar y confirmar una serie de preceptos restrictivos sobre el signo «niño», como el elemento convocante al interior del acontecimiento escénico. La pregunta por el sujeto político en el teatro para las infancias, será la base para problematizar alrededor de los procesos de acción cultural implicados en la producción de una política sexual. A través de esto sostendré que hay exclusiones constitutivas que custodian los límites de lo posible, en cuyo núcleo la heterosexualidad se torna pre-discursiva, demostrando así que hay infancias que importan. Éstas son las que se vuelven inteligibles por ser descriptas como esencialmente cisheterosexuales pero, mediante un abordaje epistemológico feminista, se demuestran como el resultado de una serie de mecanismos reguladores específicos. Finalmente, los criterios para elegir una obra para «niños» se vuelven un espacio político de fuerza prescriptiva, donde la heterosexualización de la realidad simbólica infantil se ve determinada previamente.