bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Oral GABA on the Nervous System: Potential for Therapeutic Intervention
Authors: Almutairi Shahad , Sivadas Amaya , Kwakowsky Andrea
Published: May 2024

Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system (CNS), plays a pivotal role in maintaining the delicate balance between inhibitory and excitatory neurotransmission. Dysregulation of the excitatory/inhibitory balance is implicated in various neurological and psychiatric disorders, emphasizing the critical role of GABA in disease-free brain function. The review examines the intricate interplay between the gut–brain axis and CNS function. The potential impact of dietary GABA on the brain, either by traversing the blood–brain barrier (BBB) or indirectly through the gut–brain axis, is explored. While traditional beliefs questioned GABA’s ability to cross the BBB, recent research challenges this notion, proposing specific transporter systems facilitating GABA passage. Animal studies provide some evidence that small amounts of GABA can cross the BBB but there is a lack of human data to support the role of transporter-mediated GABA entry into the brain. This review also explores GABA-containing food supplements, investigating their impact on brain activity and functions. The potential benefits of GABA supplementation on pain management and sleep quality are highlighted, supported by alterations in electroencephalography (EEG) brain responses following oral GABA intake. The comprehensive overview encompasses GABA’s sources in the diet, including brown rice, soy, adzuki beans, and fermented foods. GABA’s presence in various foods and supplements, its association with gut microbiota, and its potential as a therapeutic strategy for neurological disorders are thoroughly examined. The articles were retrieved through a systematic review of the databases: OVID, SCOPUS, and PubMed (keywords “GABA”, “oral GABA“, “sleep”, “cognition”, “neurodegenerative”, “blood-brain barrier”, “gut microbiota”, “supplements” and “therapeutic”, and by searching reference sections from identified studies and review articles). This review presents the relevant literature available on the topic and discusses the mechanisms, effects, and hypotheses that suggest oral GABA benefits range from neuroprotection to blood pressure control. The literature suggests that oral intake of GABA affects the brain illustrated by changes in EEG scans and cognitive performance, with evidence showing that GABA can have beneficial effects for multiple age groups and conditions. The potential clinical and research implications of utilizing GABA supplementation are vast, spanning a spectrum of diseases ranging from neurodegeneration to blood pressure regulation. Importantly, recommendations for the use of oral GABA should consider the dosage, formulation, and duration of treatment as well as potential side effects. Effects of GABA need to be more thoroughly investigated in robust clinical trials to validate efficacy to progress the development of alternative treatments for a variety of disorders.
Emerging and Reemerging Parasitic Diseases in Taiwan: A Retrospective Study of Clinical Case Reports in 2001~2018
Authors: Hsu Shao-Lun , Fan Chia-Kwung
Published: May 2024

Emerging and re-emerging parasitic diseases can cause significant economic burdens at national and global levels. However, governments often underestimate or ignore these diseases, especially in developed countries. This retrospective, case-oriented study analyzed parasitic diseases reported in Taiwan between 2001 and 2018. One hundred and thirty-two eligible clinical profiles of Taiwanese patients obtained from the NCBI, Scopus, Google Scholar, and Web of Science databases and local journals according to age, sex, source of infection, symptoms, risk factors, and geographical regions were analyzed. The analysis results showed that the number/frequency of cases caused by nematodes (46.97%) or protozoa (37.88%) was significantly higher than that of trematodes (9.85%) or cestodes (5.30%) (p < 0.0001). Northern Taiwan (46.97%) had a significantly higher rate than Southern Taiwan (33.33%), Central Taiwan (8.33%), and Eastern Taiwan (5.30%) (p < 0.05). The 15–65 age group (68.94%) had a significantly higher rate than the 65–90 age group (22.73%) and the 0–15 age group (8.33%) (p < 0.0001). Males (70.46%) had a significantly higher number/frequency of cases than females (29.54%) (p < 0.0001). People who acquired the infection through the food/soil route (32.58%) or who had a low immune status (32.58%) had a higher rate than travel-related infections (15.15%) (p < 0.001). The present study showed that emerging/reemerging parasitic infections continue to be of great concern to the lives and health of Taiwanese citizens and, if ignored, will threaten the health of the Taiwanese people; therefore, the delineation of preventive measures by health authorities is urgently warranted.
Development and Evaluation of a Water-Free In Situ Depot Gel Formulation for Long-Acting and Stable Delivery of Peptide Drug ACTY116
Authors: Xiong Yingxin , Liu Zhirui , Wang Yuanqiang , Wang Jiawei , Zhou Xing , Li Xiaohui
Published: May 2024

In situ depot gel is a type of polymeric long-acting injectable (pLAI) drug delivery system; compared to microsphere technology, its preparation process is simpler and more conducive to industrialization. To ensure the chemical stability of peptide ACTY116, we avoided the use of harsh conditions such as high temperatures, high shear mixing, or homogenization; maintaining a water-free and oxygen-free environment was also critical to prevent hydrolysis and oxidation. Molecular dynamics (MDs) simulations were employed to assess the stability mechanism between ACTY116 and the pLAI system. The initial structure of ACTY116 with an alpha helix conformation was constructed using SYBYL-X, and the copolymer PLGA was generated by AMBER 16; results showed that PLGA-based in situ depot gel improved conformational stability of ACTY116 through hydrogen bonds formed between peptide ACTY116 and the components of the pLAI formulation, while PLGA (Poly(DL-lactide-co-glycolide)) also created steric hindrance and shielding effects to prevent conformational changes. As a result, the chemical and conformational stability and in vivo long-acting characteristics of ACTY116 ensure its enhanced efficacy. In summary, we successfully achieved our objective of developing a highly stable peptide-loaded long-acting injectable (LAI) in situ depot gel formulation that is stable for at least 3 months under harsh conditions (40 °C, above body temperature), elucidating the underlying stabilisation mechanism, and the high stability of the ACTY116 pLAI formulation creates favourable conditions for its in vivo pharmacological activity lasting for weeks or even months.
A Novel 2-Methoxyestradiol Derivative: Disrupting Mitosis Inhibiting Cell Motility and Inducing Apoptosis in HeLa Cells In Vitro
Authors: Njangiru Isaac Kinyua , Bózsity-Faragó Noémi , Resch Vivien Erzsébet , Paragi Gábor , Frank Éva , Balogh György T. , Zupkó István , Minorics Renáta
Published: May 2024

The clinical application of 2-methoxyestradiol (2ME) in cancer therapy has been limited by its low solubility and rapid metabolism. Derivatives of 2ME have been synthesised to enhance bioavailability and decrease hepatic metabolism. Compound 4a, an analog of 2ME, has demonstrated exceptional pharmacological activity, in addition to promising pharmacokinetic profile. Our study, therefore, aimed at exploring the anticancer effects of 4a on the cervical cancer cell line, HeLa. Compound 4a exhibited a significant and dose-dependent antimetastatic and antiinvasive impact on HeLa cells, as determined by wound-healing and Boyden chamber assays, respectively. Hoechst/Propidium iodide (HOPI) double staining showcased a substantial induction of apoptosis via 4a, with minimal necrotic effect. Flow cytometry revealed a significant G2/M phase arrest, accompanied by a noteworthy rise in the sub-G1 cell population, indicating apoptosis, 18 h post-treatment. Moreover, a cell-independent tubulin polymerisation assay illustrated compound 4a’s ability to stabilise microtubules by promoting tubulin polymerisation. Molecular modelling experiments depicted that 4a interacts with the colchicine-binding site, nestled between the α and β tubulin dimers. Furthermore, 4a displayed an affinity for binding to and activating ER-α, as demonstrated by the luciferase reporter assay. These findings underscore the potential of 4a in inhibiting HPV18+ cervical cancer proliferation and cellular motility.
Susceptibility and Cixous’s Self-Strange Subject
Authors: Hughes Robert
Published: May 2024

This essay reads a short narrative, “Savoir” by Hélène Cixous, to describe susceptibility as a problem organized around two lines of impingement: between subject and world and between consciousness and the wayward impulses of interior life. The young girl in Cixous’s text suffers a moment of disorientation and distress one misty morning and, against presumptions of inviolability and ideals of subjective consistency, this unhappy event comes to resonate with her disappointed trust in the generosity of the world, her anxious sense of betrayal with respect to those who ought to protect her and her insecurity about her own role in this complex of associations. The frame of susceptibility thus opens up a space for Cixous’s reader and this essay to think the subject in her inconsistency and self-strangeness.
Genetic Dissection of Diverse Seed Coat Patterns in Cowpea through a Comprehensive GWAS Approach
Authors: Xiong Haizheng , Chen Yilin , Ravelombola Waltram , Mou Beiquan , Sun Xiaolun , Zhang Qingyang , Xiao Yiting , Tian Yang , Luo Qun , Alatawi Ibtisam , Chiwina Kenani Edward , Alkabkabi Hanan Mohammedsaeed , Shi Ainong
Published: May 2024

This study investigates the genetic determinants of seed coat color and pattern variations in cowpea (Vigna unguiculata), employing a genome-wide association approach. Analyzing a mapping panel of 296 cowpea varieties with 110,000 single nucleotide polymorphisms (SNPs), we focused on eight unique coat patterns: (1) Red and (2) Cream seed; (3) White and (4) Brown/Tan seed coat; (5) Pink, (6) Black, (7) Browneye and (8) Red/Brown Holstein. Across six GWAS models (GLM, SRM, MLM, MLMM, FarmCPU from GAPIT3, and TASSEL5), 13 significant SNP markers were identified and led to the discovery of 23 candidate genes. Among these, four specific genes may play a direct role in determining seed coat pigment. These findings lay a foundational basis for future breeding programs aimed at creating cowpea varieties aligned with consumer preferences and market requirements.
Gibberellin Positively Regulates Tomato Resistance to Tomato Yellow Leaf Curl Virus (TYLCV)
Authors: Zhang Chenwei , Wang Dandan , Li Yan , Wang Zifan , Wu Zhiming , Zhang Qingyin , Jia Hongwei , Dong Xiaoxu , Qi Lianfen , Shi Jianhua , Shang Zhonglin
Published: May 2024

Tomato yellow leaf curl virus (TYLCV) is a prominent viral pathogen that adversely affects tomato plants. Effective strategies for mitigating the impact of TYLCV include isolating tomato plants from the whitefly, which is the vector of the virus, and utilizing transgenic lines that are resistant to the virus. In our preliminary investigations, we observed that the use of growth retardants increased the rate of TYLCV infection and intensified the damage to the tomato plants, suggesting a potential involvement of gibberellic acid (GA) in the conferring of resistance to TYLCV. In this study, we employed an infectious clone of TYLCV to inoculate tomato plants, which resulted in leaf curling and growth inhibition. Remarkably, this inoculation also led to the accumulation of GA3 and several other phytohormones. Subsequent treatment with GA3 effectively alleviated the TYLCV-induced leaf curling and growth inhibition, reduced TYLCV abundance in the leaves, enhanced the activity of antioxidant enzymes, and lowered the reactive oxygen species (ROS) levels in the leaves. Conversely, the treatment with PP333 exacerbated TYLCV-induced leaf curling and growth suppression, increased TYLCV abundance, decreased antioxidant enzyme activity, and elevated ROS levels in the leaves. The analysis of the gene expression profiles revealed that GA3 up-regulated the genes associated with disease resistance, such as WRKYs, NACs, MYBs, Cyt P450s, and ERFs, while it down-regulated the DELLA protein, a key agent in GA signaling. In contrast, PP333 induced gene expression changes that were the opposite of those caused by the GA3 treatment. These findings suggest that GA plays an essential role in the tomato’s defense response against TYLCV and acts as a positive regulator of ROS scavenging and the expression of resistance-related genes.
Fracture Toughness, Radiation Hardness, and Processibility of Polymers for Superconducting Magnets
Authors: Gaarud Anders , Scheuerlein Christian , Parragh David Mate , Clement Sébastien , Bertsch Jacob , Urscheler Cedric , Piccin Roland , Ravotti Federico , Pezzullo Giuseppe , Lach Ralf
Published: May 2024

High fracture toughness at cryogenic temperature and radiation hardness can be conflicting requirements for the resins for the impregnation of superconducting magnet coils. The fracture toughness of different epoxy-resin systems at room temperature (RT) and at 77 K was measured, and their toughness was compared with that determined for a polyurethane, polycarbonate (PC) and poly(methyl methacrylate) (PMMA). Among the epoxy resins tested in this study, the MY750 system has the highest 77 K fracture toughness of KIC = 4.6 MPa√m, which is comparable to the KIC of PMMA, which also exhibits linear elastic behaviour and unstable crack propagation. The polyurethane system tested has a much higher 77 K toughness than the epoxy resins, approaching the toughness of PC, which is known as one of the toughest polymer materials. CTD101K is the least performing in terms of fracture toughness. Despite this, it is used for the impregnation of large Nb3Sn coils for its good processing capabilities and relatively high radiation resistance. In this study, the fracture toughness of CTD101K was improved by adding the polyglycol flexibiliser Araldite DY040 as a fourth component. The different epoxy-resin systems were exposed to proton and gamma doses up to 38 MGy, and it was found that adding the DY040 flexibiliser to the CTD101K system did not significantly change the irradiation-induced ageing behaviour. The viscosity evolution of the uncured resin mix is not significantly changed when adding the DY040 flexibiliser, and at the processing temperature of 60 °C, the viscosity remains below 200 cP for more than 24 h. Therefore, the new resin referred to as POLAB Mix is now used for the impregnation of superconducting magnet coils.
Effect of Long Glass Fiber Orientations or a Short-Fiber-Reinforced Composite on the Fracture Resistance of Endodontically Treated Premolars
Authors: Hazar Ecehan , Hazar Ahmet
Published: May 2024

This study aimed to evaluate the effect of direct restorations using unidirectional glass fiber orientations and a short-fiber-reinforced composite (SFRC) on the fracture resistance of endodontically treated premolars with mesio-occluso-distal cavities. Ninety double-rooted premolars were selected. Fifteen teeth were left intact/as a control group. The endodontic treatment and cavity preparations of seventy-five teeth were performed and divided into five experimental groups: Resin composite (RC), modified transfixed technique + RC, circumferential technique + RC, cavity floor technique + RC, and SFRC + RC. All teeth were fractured under oblique static loading at a 30° angle using a universal testing machine. The fracture patterns were observed and classified. Data were analyzed with one-way analysis of variance, Pearson chi-square, and Tukey HSD post hoc tests (p = 0.05). The highest fracture strength values were obtained in intact teeth (599.336 N), followed by modified transfixed + RC treated teeth (496.58 N), SFRC + RC treated teeth (469.62 N), RC (443.51 N), circumferential + RC treated teeth (442.835 N), and cavity floor + RC treated teeth (404.623 N) (p < 0.05). There was no significant difference between the RC and the circumferential technique + RC (p > 0.05). Unrepairable fractures were observed at low rates (20%) in the modified transfixed + RC and SFRC + RC teeth, and at higher rates in RC (73.3%), cavity floor + RC (60%), and circumferential + RC (80%) teeth. The application of an SFRC or the modified transfixed technique yielded an improved fracture strength and the fracture pattern of ETPs being restored with a universal injectable composite.
Biodegradable Biocomposite of Starch Films Cross-Linked with Polyethylene Glycol Diglycidyl Ether and Reinforced by Microfibrillated Cellulose
Authors: González-Pérez María M. , Lomelí-Ramírez María G. , Robledo-Ortiz Jorge R. , Silva-Guzmán José A. , Manríquez-González Ricardo
Published: May 2024

Biopolymers are biodegradable and renewable and can significantly reduce environmental impacts. For this reason, biocomposites based on a plasticized starch and cross-linker matrix and with a microfibrillated OCC cardboard cellulose reinforcement were developed. Biocomposites were prepared by suspension casting with varied amounts of microfibrillated cellulose: 0, 4, 8, and 12 wt%. Polyethylene glycol diglycidyl ether (PEGDE) was used as a cross-linking, water-soluble, and non-toxic agent. Microfibrillated cellulose (MFC) from OCC cardboard showed appropriate properties and potential for good performance as a reinforcement. In general, microfiber incorporation and matrix cross-linking increased crystallization, reduced water adsorption, and improved the physical and tensile properties of the plasticized starch. Biocomposites cross-linked with PEGDE and reinforced with 12 wt% MFC showed the best properties. The chemical and structural changes induced by the cross-linking of starch chains and MFC reinforcement were confirmed by FTIR, NMR, and XRD. Biodegradation higher than 80% was achieved for most biocomposites in 15 days of laboratory compost.
Polyethylene Film Surface Modification via Benzoic Acid Grafting
Authors: Grafia Ana Luisa , Barbosa Silvia Elena
Published: May 2024

A polyethylene (PE) film surface modification method is proposed via benzoic acid (BA) alkylation grafting to improve the surface affinity to polar substances. The procedure involves sequentially spraying AlCl3 and BA onto the heat-softened PE surface. The occurrence of the alkylation reaction was evaluated through comparative chemical, morphological, and thermal analyses. It was demonstrated that the grafting reaction of BA onto the PE film surface took place, limited to the surface layer, while preserving the bulk properties of PE. The reaction resulted in the formation of aluminum benzoate complexes, which improved the surface affinity to polar compounds. The impact of grafting on the surface properties of PE was further assessed by comparing the behavior of PE films treated with BA and untreated PE films when painted with watercolors. The PE film grafted with BA exhibited increased affinity towards watercolors, providing strong evidence of a change in surface polarity from hydrophobic to hydrophilic. These findings indicate that the proposed methodology effectively renders the PE surface paintable, even with non-toxic water-based inks, making it suitable for applications such as packaging.
Mechanisms of Groundwater Damage to Overlying Rock in Goaf
Authors: Zhu Nan , Liu Fei , Sun Dafa
Published: May 2024

The discontinuation of pumping and drainage activities upon the cessation of mining operations leads to the gradual accumulation of groundwater. This inflow into mined-out areas affects the properties of the rock, disturbing the previously stable goaf and exacerbating instability. In this study, we advance an existing theoretical framework pertaining to the residual deformation of mines by delineating the mechanisms through which groundwater influences the degradation of the overlying strata in goaf areas. Using analogous material simulation experiments and rigorous theoretical analyses, we clarify the specific mechanisms by which groundwater causes structural damage to these regions. The deformation of overlying rock is divided into three different forms: the compressive deformation of rock, the sliding instability of rock, and the rotational instability of rock. The main contributions of this study are its refinement of the existing theory of the residual deformation of mines, an analysis of the damage mechanisms of groundwater, and suggestions regarding technical support for targeted treatment measures in affected mines.
How Moral Distress Contributes to Depression Varies by Gender in a Sample of Sub-Saharan African Nurses
Authors: Chukwuorji JohnBosco Chika , Nwogiji Michael Onwe , Ifeagwazi Chuka Mike , Eke Okechukwu Hope , Obed-Ohen Dumkelechuku , Osondu Oluchi Miracle , Rukmi Dwi Kartika , Njoku Crystal , Chike-Okoli Adaeze
Published: May 2024

Although research has shown that moral distress harms mental health in diverse populations, information on potential moderators of such associations is scarce. In a sample of sub-Saharan African nurses, we examined the link between moral distress and depressive symptoms. We explored for whom and when such relationships may hold with regard to gender, age, and work experience. Participants consisted of 398 nurses drawn from a tertiary healthcare institution in southeastern Nigeria. Data were collected using the Moral Distress Questionnaire (MDQ) for clinical nurses, and the Center for Epidemiological Studies Depression Scale Revised (CEDS-R). Hayes regression-based macro results for the moderation effects indicated that the association of high moral distress with increased depressive symptoms was robust for women but not significant for men. Although older age and higher years of nursing experience were associated with reduced symptoms of depression, nurses’ age and years of work experience did not moderate the relationship between moral distress and depressive symptoms. To promote mental well-being and preserve the integrity of nurses, gender-based differentials in how morals contribute depressive symptoms should be considered in policy and practice.
Contributions of the Synodal Process to the Religious Life of Adult Believers in Christian Communities
Authors: Vranješ Nikola
Published: May 2024

Synodality, as a determinant of the mentality and style of pastoral activity, has proven to be one of the key themes of Church life in the last few years. The synodal dimension of the Church is seen as the fundamental backbone of all the other important components of pastoral engagement. Religious life and practice of adult believers, on the other hand, remains one of the most challenging pastoral tasks. This claim is so current that concerning many church environments one can legitimately ask whether a mature and developed practice of faith exists at all. The synodal process that is ongoing in the Catholic Church, especially until the fall of 2024, helps to improve so many pastoral activities and most of them concern the practice of faith of adult believers. This paper is dedicated to the theological–pastoral study of the main components of the improvement of this practice in light of the contributions of the synodal process.
Reimagining Violence in Contemporary Africa: Catholic Martyrdom and the Ethics of Sacrificial Solidarity in Burundi
Authors: Mikalachki Jodi
Published: May 2024

This article discusses the enculturated Catholic ethics of martyrdom embodied by the Martyrs of Fraternity of Burundi, a group of students whose cause is now before the Vatican’s Congregation for the Causes of Saints for refusing to separate into Hutus and Tutsis during Burundi’s 1993–2005 civil war. Engaging Fratelli Tutti from a local African perspective, it considers how the conviction that all human beings are brothers and sisters is to find concrete embodiment. Its argument develops Emmanuel Katongole’s assertion that the African church provides a living witness of what hope looks like in contexts of violence and war, drawing on Burundian scholarship and more than sixty interviews conducted in Burundi from 2018 to 2024 to develop a thick narrative of fraternal martyrdom and the ethics of Ubuntu. By placing sacrificial solidarity rather than violence at the center of the story of the Martyrs of Fraternity, Burundian Catholics reimagine their civil war in ethical terms. This Burundian embodiment of an ethics of sacrificial solidarity, solidly grounded in its original cultural substratum, stands as a resource for a world increasingly engulfed by war, refusing to let violence have the last word in a story of fraternal love hallowed by sacrifice.
MVT: Multi-Vision Transformer for Event-Based Small Target Detection
Authors: Jing Shilong , Lv Hengyi , Zhao Yuchen , Liu Hailong , Sun Ming
Published: May 2024

Object detection in remote sensing plays a crucial role in various ground identification tasks. However, due to the limited feature information contained within small targets, which are more susceptible to being buried by complex backgrounds, especially in extreme environments (e.g., low-light, motion-blur scenes). Meanwhile, event cameras offer a unique paradigm with high temporal resolution and wide dynamic range for object detection. These advantages enable event cameras without being limited by the intensity of light, to perform better in challenging conditions compared to traditional cameras. In this work, we introduce the Multi-Vision Transformer (MVT), which comprises three efficiently designed components: the downsampling module, the Channel Spatial Attention (CSA) module, and the Global Spatial Attention (GSA) module. This architecture simultaneously considers short-term and long-term dependencies in semantic information, resulting in improved performance for small object detection. Additionally, we propose Cross Deformable Attention (CDA), which progressively fuses high-level and low-level features instead of considering all scales at each layer, thereby reducing the computational complexity of multi-scale features. Nevertheless, due to the scarcity of event camera remote sensing datasets, we provide the Event Object Detection (EOD) dataset, which is the first dataset that includes various extreme scenarios specifically introduced for remote sensing using event cameras. Moreover, we conducted experiments on the EOD dataset and two typical unmanned aerial vehicle remote sensing datasets (VisDrone2019 and UAVDT Dataset). The comprehensive results demonstrate that the proposed MVT-Net achieves a promising and competitive performance.
Remote Detection of Geothermal Alteration Using Airborne Light Detection and Ranging Return Intensity
Authors: Freski Yan Restu , Hecker Christoph , Meijde Mark van der , Setianto Agung
Published: May 2024

The remote detection of hydrothermally altered grounds in geothermal exploration demands datasets capable of reliably detecting key outcrops with fine spatial resolution. While optical thermal or radar-based datasets have resolution limitations, airborne LiDAR offers point-based detection through its LiDAR return intensity (LRI) values, serving as a proxy for surface reflectivity. Despite this potential, few studies have explored LRI value variations in the context of hydrothermal alteration and their utility in distinguishing altered from unaltered rocks. Although the link between alteration degree and LRI values has been established under laboratory conditions, this relationship has yet to be demonstrated in airborne data. This study investigates the applicability of laboratory results to airborne LRI data for alteration detection. Utilising LRI data from an airborne LiDAR point cloud (wavelength 1064 nm, density 12 points per square metre) acquired over a prospective geothermal area in Bajawa, Indonesia, where rock sampling for a related laboratory study took place, we compare the airborne LRI values within each ground sampling area of a 3 m radius (due to hand-held GPS uncertainty) with laboratory LRI values of corresponding rock samples. Our findings reveal distinguishable differences between strongly altered and unaltered samples, with LRI discrepancies of approximately ~28 for airborne data and ~12 for laboratory data. Furthermore, the relative trends of airborne and laboratory-based LRI data concerning alteration degree exhibit striking similarity. These consistent results for alteration degree in laboratory and airborne data mark a significant step towards LRI-based alteration mapping from airborne platforms.
Terrace Extraction Method Based on Remote Sensing and a Novel Deep Learning Framework
Authors: Zhao Yinghai , Zou Jiawei , Liu Suhong , Xie Yun
Published: May 2024

Terraces, farmlands built along hillside contours, are common anthropogenically designed landscapes. Terraces control soil and water loss and improve land productivity; therefore, obtaining their spatial distribution is necessary for soil and water conservation and agricultural production. Spatial information of large-scale terraces can be obtained using satellite images and through deep learning. However, when extracting terraces, accurately segmenting the boundaries of terraces and identifying small terraces in diverse scenarios continues to be challenging. To solve this problem, we combined two deep learning modules, ANB-LN and DFB, to produce a new deep learning framework (NLDF-Net) for terrace extraction using remote sensing images. The model first extracted the features of the terraces through the coding area to obtain abstract semantic features, and then gradually recovered the original size through the decoding area using feature fusion. In addition, we constructed a terrace dataset (the HRT-set) for Guangdong Province and conducted a series of comparative experiments on this dataset using the new framework. The experimental results show that our framework had the best extraction effect compared to those of other deep learning methods. This framework provides a method and reference for extracting ground objects using remote sensing images.
Leveraging Temporal Information to Improve Machine Learning-Based Calibration Techniques for Low-Cost Air Quality Sensors
Authors: Ali Sharafat , Alam Fakhrul , Potgieter Johan , Arif Khalid Mahmood
Published: May 2024

Low-cost ambient sensors have been identified as a promising technology for monitoring air pollution at a high spatio-temporal resolution. However, the pollutant data captured by these cost-effective sensors are less accurate than their conventional counterparts and require careful calibration to improve their accuracy and reliability. In this paper, we propose to leverage temporal information, such as the duration of time a sensor has been deployed and the time of day the reading was taken, in order to improve the calibration of low-cost sensors. This information is readily available and has so far not been utilized in the reported literature for the calibration of cost-effective ambient gas pollutant sensors. We make use of three data sets collected by research groups around the world, who gathered the data from field-deployed low-cost CO and NO2 sensors co-located with accurate reference sensors. Our investigation shows that using the temporal information as a co-variate can significantly improve the accuracy of common machine learning-based calibration techniques, such as Random Forest and Long Short-Term Memory.
Arduino-Based Readout Electronics for Nuclear and Particle Physics
Authors: Köhli Markus , Weimar Jannis , Schmidt Simon , Schmidt Fabian P. , Lambertz Alexander , Weber Laura , Kaminski Jochen , Schmidt Ulrich
Published: May 2024

Open Hardware-based microcontrollers, especially the Arduino platform, have become a comparably easy-to-use tool for rapid prototyping and implementing creative solutions. Such devices in combination with dedicated front-end electronics can offer low-cost alternatives for student projects, slow control and independently operating small-scale instrumentation. The capabilities can be extended to data taking and signal analysis at mid-level rates. Two detector realizations are presented, which cover the readouts of proportional counter tubes and of scintillators or wavelength-shifting fibers with silicon photomultipliers (SiPMs). The SiPMTrigger realizes a small-scale design for coincidence readout of SiPMs as a trigger or veto detector. It consists of a custom mixed signal front-end board featuring signal amplification, discrimination and a coincidence unit for rates of up to 200 kHz. The nCatcher transforms an Arduino Nano to a proportional counter readout with pulse shape analysis: time over threshold measurement and a 10-bit analog-to-digital converter for pulse heights. The device is suitable for low-to-medium-rate environments up to 5 kHz, where a good signal-to-noise ratio is crucial. We showcase the monitoring of thermal neutrons. For data taking and slow control, a logger board is presented that features an SD card and GSM/LoRa interface.
Gait Pattern Analysis: Integration of a Highly Sensitive Flexible Pressure Sensor on a Wireless Instrumented Insole
Authors: Das Partha Sarati , Skaf Daniella , Rose Lina , Motaghedi Fatemeh , Carmichael Tricia Breen , Rondeau-Gagné Simon , Ahamed Mohammed Jalal
Published: May 2024

Gait phase monitoring wearable sensors play a crucial role in assessing both health and athletic performance, offering valuable insights into an individual’s gait pattern. In this study, we introduced a simple and cost-effective capacitive gait sensor manufacturing approach, utilizing a micropatterned polydimethylsiloxane dielectric layer placed between screen-printed silver electrodes. The sensor demonstrated inherent stretchability and durability, even when the electrode was bent at a 45-degree angle, it maintained an electrode resistance of approximately 3 Ω. This feature is particularly advantageous for gait monitoring applications. Furthermore, the fabricated flexible capacitive pressure sensor exhibited higher sensitivity and linearity at both low and high pressure and displayed very good stability. Notably, the sensors demonstrated rapid response and recovery times for both under low and high pressure. To further explore the capabilities of these new sensors, they were successfully tested as insole-type pressure sensors for real-time gait signal monitoring. The sensors displayed a well-balanced combination of sensitivity and response time, making them well-suited for gait analysis. Beyond gait analysis, the proposed sensor holds the potential for a wide range of applications within biomedical, sports, and commercial systems where soft and conformable sensors are preferred.
Motion Capture Technology in Sports Scenarios: A Survey
Authors: Suo Xiang , Tang Weidi , Li Zhen
Published: May 2024

Motion capture technology plays a crucial role in optimizing athletes’ skills, techniques, and strategies by providing detailed feedback on motion data. This article presents a comprehensive survey aimed at guiding researchers in selecting the most suitable motion capture technology for sports science investigations. By comparing and analyzing the characters and applications of different motion capture technologies in sports scenarios, it is observed that cinematography motion capture technology remains the gold standard in biomechanical analysis and continues to dominate sports research applications. Wearable sensor-based motion capture technology has gained significant traction in specialized areas such as winter sports, owing to its reliable system performance. Computer vision-based motion capture technology has made significant advancements in recognition accuracy and system reliability, enabling its application in various sports scenarios, from single-person technique analysis to multi-person tactical analysis. Moreover, the emerging field of multimodal motion capture technology, which harmonizes data from various sources with the integration of artificial intelligence, has proven to be a robust research method for complex scenarios. A comprehensive review of the literature from the past 10 years underscores the increasing significance of motion capture technology in sports, with a notable shift from laboratory research to practical training applications on sports fields. Future developments in this field should prioritize research and technological advancements that cater to practical sports scenarios, addressing challenges such as occlusion, outdoor capture, and real-time feedback.
Damage Severity Assessment of Multi-Layer Complex Structures Based on a Damage Information Extraction Method with Ladder Feature Mining
Authors: Tu Jiajie , Yan Jiajia , Ji Xiaojin , Liu Qijian , Qing Xinlin
Published: May 2024

Multi-layer complex structures are widely used in large-scale engineering structures because of their diverse combinations of properties and excellent overall performance. However, multi-layer complex structures are prone to interlaminar debonding damage during use. Therefore, it is necessary to monitor debonding damage in engineering applications to determine structural integrity. In this paper, a damage information extraction method with ladder feature mining for Lamb waves is proposed. The method is able to optimize and screen effective damage information through ladder-type damage extraction. It is suitable for evaluating the severity of debonding damage in aluminum-foamed silicone rubber, a novel multi-layer complex structure. The proposed method contains ladder feature mining stages of damage information selection and damage feature fusion, realizing a multi-level damage information extraction process from coarse to fine. The results show that the accuracy of damage severity assessment by the damage information extraction method with ladder feature mining is improved by more than 5% compared to other methods. The effectiveness and accuracy of the method in assessing the damage severity of multi-layer complex structures are demonstrated, providing a new perspective and solution for damage monitoring of multi-layer complex structures.
Dielectric Properties of Materials Used for Microwave-Based NOx Gas Dosimeters
Authors: Walter Stefanie , Baumgärtner Johanna , Hagen Gunter , Schönauer-Kamin Daniela , Kita Jaroslaw , Moos Ralf
Published: May 2024

Nitrogen oxides (NOx), primarily generated from combustion processes, pose significant health and environmental risks. To improve the coordination of measures against excessive NOx emissions, it is necessary to effectively monitor ambient NOx concentrations, which requires the development of precise and cost-efficient detection methods. This study focuses on developing a microwave- or radio frequency (RF)-based gas dosimeter for NOx detection and addresses the optimization of the dosimeter design by examining the dielectric properties of LTCC-based (Low-Temperature Co-fired Ceramics) sensor substrates and barium-based NOx storage materials. The measurements taken utilizing the Microwave Cavity Perturbation (MCP) method revealed that these materials exhibit more pronounced changes in dielectric losses when storing NOx at elevated temperatures. Consequently, operating such a dosimeter at high temperatures (above 300 °C) is recommended to maximize the sensor signal. To evaluate their high-temperature applicability, LTCC substrates were analyzed by measuring their dielectric losses at temperatures up to 600 °C. In terms of NOx storage materials, coating barium on high-surface-area alumina resolved issues related to limited NOx adsorption in pure barium carbonate powders. Additionally, the adsorption of both NO and NO2 was enabled by the application of a platinum catalyst. The change in dielectric losses, which provides the main signal for an RF-based gas dosimeter, only depends on the stored amount of NOx and not on the specific type of nitrogen oxide. Although the change in dielectric losses increases with the temperature, the maximum storage capacity of the material decreases significantly. In addition, at temperatures above 350 °C, NOx is mostly weakly bound, so it will desorb in the absence of NOx. Therefore, in the future development of a reliable RF-based NOx dosimeter, the trade-off between the sensor signal strength and adsorption behavior must be addressed.
Quantitative 1H NMR Spectroscopy Method for Determination of Anthraquinone Derivatives in Extracts from Rubia tinctorum L. Roots and Rhizomes
Authors: Vasil’ev Vasilii , Sheremeta Anzhelika , Ivlev Vasilii , Goriainov Sergey , Hajjar Fadi , Esparza Cesar , Platonov Evgeniy , Khromov Arkadiy , Kolesnov Alexandr , Romashchenko Victoria , Kalabin Gennady
Published: May 2024

The roots and rhizomes of Rubia tinctorum L. have been widely used both for industrial and medicinal purposes for centuries. The primary biologically active substances from Rubia tinctorum L. roots and rhizomes are anthraquinone derivatives such as ruberythric acid and lucidin-3-primeveroside. Their identification and quantification are carried out by various analytical methods, requiring a complicated sample preparation as well as special reagents and reference samples. However, NMR spectroscopy has no limitations of this kind. In this work, we have developed and validated a new express and standard-free method for the qualitative and quantitative analysis of ruberythric acid and lucidin-3-primeveroside by 1H NMR spectroscopy in the extracts from the roots and rhizomes of Rubia tinctorum L. In this work, we have optimized the conditions of the sample preparation and registration of 1H NMR spectra, determined the optimal solvent and reference compound and confirmed the obtained results by HPLC-UV-MS.
Exploring Motivators for Trust in the Dichotomy of Human—AI Trust Dynamics
Authors: Gerlich Michael
Published: May 2024

This study analyses the dimensions of trust in artificial intelligence (AI), focusing on why a significant portion of the UK population demonstrates a higher level of trust in AI compared to humans. Conducted through a mixed-methods approach, this study gathered 894 responses, with 451 meeting the criteria for analysis. It utilised a combination of a six-step Likert-scale survey and open-ended questions to explore the psychological, sociocultural, and technological facets of trust. The analysis was underpinned by structural equation modelling (SEM) and correlation techniques. The results unveil a strong predilection for trusting AI, mainly due to its perceived impartiality and accuracy, which participants likened to conventional computing systems. This preference starkly contrasts with the scepticism towards human reliability, which is influenced by the perception of inherent self-interest and dishonesty in humans, further exacerbated by a general distrust in media narratives. Additionally, this study highlights a significant correlation between distrust in AI and an unwavering confidence in human judgment, illustrating a dichotomy in trust orientations. This investigation illuminates the complex dynamics of trust in the era of digital technology, making a significant contribution to the ongoing discourse on AI’s societal integration and underscoring vital considerations for future AI development and policymaking.
“We Cannot Go There, They Cannot Come Here”: Dispersed Care, Asian Indian Immigrant Families and the COVID-19 Pandemic
Authors: Roy Rianka , Purkayastha Bandana , Chacko Elizabeth
Published: May 2024

The COVID-19 pandemic disrupted families and displaced individuals. For migrant workers, these disruptions and displacements exacerbated the state-imposed constraints on family formation. But how did high-skilled and high-wage immigrants, presumably immune from these challenges, provide care to and receive care from families during the pandemic? Based on 33 in-depth interviews with high-skilled Asian Indian immigrants in the USA during the pandemic, we note disruptions in their care to and from families. These disruptions reveal a persistent pattern of dispersion in immigrant families which leads to what we call “dispersed care.” By “dispersed care” we identify the effects of various state-imposed immigration laws and policies, which force immigrants to divide and allocate care among multiple fragments of their families in home and host countries. Dispersed care affects immigrant workers’ professional output, forcing them to make difficult choices between their career and care commitments. To unsettle the assumed homogeneity of high-skilled “Asian Indians,” we choose participants at diverse intersections of their migration pathways—naturalized US citizens, permanent US residents, and temporary visa holders or nonimmigrants. While naturalized US citizens and permanent residents have better resources to maintain transnational family ties than nonimmigrants, all of them face the intersectional challenges of dispersed care.
Analysing Pre-Operative Gait Patterns Using Inertial Wearable Sensors: An Observational Study of Participants Undergoing Total Hip and Knee Replacement
Authors: Natarajan Pragadesh , Yin Ashley Lim Cha , Fonseka R. Dineth , Abi-Hanna David , Rooke Kaitlin , Sy Luke , Maharaj Monish , Broe David , Koinis Lianne , Mobbs Ralph Jasper
Published: May 2024

Background. Knee and hip arthroplasty are two of the most frequently performed procedures in orthopaedic surgery. They are associated with positive patient-reported outcomes and significant improvements in quality of life for patients. Despite this, there may be room for further progress by quantifying functional improvements with gait analysis. Our study therefore aims to characterise the disease-specific gait pattern of participants with knee and hip osteoarthritis undergoing total joint replacement using a single chest-based wearable sensor. Methods. Twenty-nine participants awaiting total hip replacement and 28 participants awaiting total knee replacement underwent three-dimensional motion analysis with inertial wearable sensors. These gait metrics were then compared with 28 healthy controls of similar ages. Differences in gait metrics were evaluated using a T-test. The participants were recruited through a single centre to participate in this cross-sectional observational study. Participants with osteoarthritis severity sufficient to warrant surgical intervention were considered for inclusion in our study. The participants were instructed to walk 15–120 m in a hospital environment while fitted with a chest-based wearable sensor. Results. In total, three domains were evaluated, including spatiotemporal, variability and asymmetry parameters. There were marked variations in the gait asymmetry parameters and step length variation in both the hip and knee osteoarthritis patients compared with the healthy controls. The magnitude of gait deterioration in terms of step length asymmetry was greater on average in the hip osteoarthritis group than the knee group. The hip osteoarthritis (+180%, p < 0.001) and knee osteoarthritis (+129%, p = 0.001) groups demonstrated marked differences in step length asymmetry. Discussion. A single chest-based sensor was found to be capable of detecting pathological gait signatures in osteoarthritis patients when compared with age-matched controls. Future studies should compare pre- and postoperative changes to disease-specific gait impairments to validate the use of wearable sensors as a clinical adjunct.