bluuebunny/crossref_metadata_2025 huggingface dataset:
REALIZAÇÃO DO LIVRE PLANEJAMENTO FAMILIAR DAS FAMÍLIAS ECTOGENÉTICAS MEDIANTE CONTRATO DE COPARENTALIDADE
Authors: Dos Reis Amaro Mylene Manfrinato , Ciscto Yoshioka Anara Rebeca , Galdino Cardin Valéria Silva
Published: September 2023

O artigo busca avaliar se as novas configurações familiares trouxeram desafios ao Direito a partir das famílias coparentais ectogenéticas. O problema que orienta a pesquisa pode ser sintetizado na seguinte pergunta: em que medida um simples contrato de coparentalidade pode ser considerado válido e eficaz para gerar efeitos jurídicos no planejamento familiar de famílias coparentais ectogenéticas? Com base nos dados levantados a partir de um conjunto de pesquisas realizadas sobre o tema na área do Direito, refletidas na bibliografia que dá sustentação ao presente estudo, torna-se possível afirmar que a falta de regulamentação jurídica do tema pode ser um empecilho para a aceitação desse contrato na reprodução humana assistida. O objetivo geral do texto consiste em avaliar a eficácia jurídica do contrato de coparentalidade para gerar efeitos jurídicos como o registro da parentalidade da criança e outras disposições para a efetivação do livre planejamento familiar e constituição de uma família ectogenética. Os objetivos específicos do texto, que se refletem na sua estrutura em três seções, são: a) ponderar a realização da dignidade da pessoa humana mediante o princípio do livre planejamento familiar e da pluralidade das entidades familiares;  b) verificar a eficácia jurídica e os requisitos do contrato de coparentalidade diante do Direito Civil brasileiro; c) analisar as técnicas de reprodução humana assistida perante a Resolução 2.294/2021, do CFM e a possibilidade de formação de famílias coparentais ectogenéticas mediante contrato. O método de pesquisa utilizado foi o hipotético-dedutivo, mediante e emprego da técnica de pesquisa bibliográfica e documental.
ESTADO BRASILEIRO E BANCOS SOB NOVAS FUNDAÇÕES INSTITUCIONAIS
Authors: Salomon Bezerra Mouallem Pedro
Published: September 2023

Características centrais do atual sistema financeiro brasileiro foram forjadas ao longo da implementação de reformas bancárias, entre 1994 e 2002. Apesar de sua importância, não se tem ainda um balanço apropriado das reformas dos anos 1990. Estudos existentes se contradizem em suas descrições e conclusões sobre as motivações, o papel do Estado e as consequências das reformas. Este artigo apresenta uma revisão abrangente dessa literatura e indica suas principais lacunas. Além disso, argumenta que as reformas dos anos 1990 estabeleceram novas fundações institucionais para a atividade bancária, sua regulação e, em especial, para a relação entre Estado e bancos no país. A pesquisa apresenta a política da mudança institucional, descrevendo as motivações em disputa e o andamento da implementação das reformas, que culminaram em novas formas de organização da propriedade, de produção e compartilhamento de informações, de regulação e de mecanismos para casos de falhas de participantes. A pesquisa baseia-se em análise qualitativa de conteúdo de documentos do período.
DIREITO ADMINISTRATIVO COMO AVENTURA EXISTENCIAL E AS PERIPÉCIAS DE APRENDER
Authors: Sundfeld Carlos Ari
Published: September 2023

Balanço das orientações e fontes normativas gerais do direito administrativo brasileiro entre as décadas de 1970 e 2020, e de sua relação com as situações política, econômica e social do país. Análise, a partir da vivência do autor neste período, das práticas habituais e alternativas para o ensino da disciplina. Defesa da orientação realista, pragmática e cética como caminho para o desenvolvimento do ramo, bem como de metodologias ativas para propiciar um aprendizado efetivo e transformador.
DIREITO ADMINISTRATIVO
Authors: Binenbojm Gustavo
Published: September 2023

O texto expõe a evolução contemporânea do direito administrativo brasileiro na perspectiva do autor. Sintetizando as mutações mais relevantes da disciplina, o autor discorre sobre o que denomina de giros democrático-constitucional e pragmático, procurando atender às exigências políticas, econômicas e sociais de seu tempo.
DIREITO ADMINISTRATIVO COMO AVENTURA GLOBAL E AS PERIPÉCIAS DE UMA COMPARATIVISTA
Authors: Mota Prado Mariana
Published: September 2023

Esse artigo argumenta que o ensino do direito administrativo pode ser enriquecido com uma perspectiva de direito comparado. Usando a experiência pessoal e a trajetória intelectual da autora, o artigo mostra alguns dos benefícios, mas também os desafios e dificuldades de se adotar essa visão comparada tanto na pesquisa quanto no ensino.
The Utilization of Picture Storybook: Can It Increase Students’ Critical and Creative Thinking Skills?
Authors: Rindengan Mersty
Published: September 2023

Learning media play an essential role in the development of students' skills. However, the use of learning media remains low, particularly in developing students' critical and creative thinking skills. This study aims to analyze the increase in critical and creative thinking skills of fifth-grade students in participating in learning using the picture storybook learning media. This study was quasi-experimental and utilized pre- and post-test designs. The subjects of this study were 50 students of a fifth-grade elementary school in cluster IV of Sintang District. The research sample was taken using a purposive sampling technique. The research instrument used was a test instrument to measure students' critical and creative thinking skills. Research data were analyzed using statistical tests, namely the MANOVA test and the independent sample t-test. The results of this study indicate a significant increase in students who learn by utilizing picture storybook learning media in terms of critical and creative thinking skills.
Effect of Social Advertising and the Effectiveness of Media- A Study of Swacch Bharat Abhiyan with special reference to youth in Varanasi
Authors: KuFarooqueri Asma , Singh Chandrashekhar
Published: September 2023

Clean India Mission was launched on 2nd of October 2014 (145th birth anniversary of Mahatma Gandhi), targeting to achieve completion on the occasion of the 150th birth anniversary year (2019)of Mahatma Gandhi. The mission was implemented to cover all the rural and urban areas of India under the Ministry of Urban Development and the Ministry of Drinking Water and Sanitation. The primary objective of this mission is to spread awareness on cleanliness, which is socially acceptable and has been a big area of concern. Central government has also launched several advertising campaigns for different media vehicles like electronic, print media for spreading the awareness about cleanliness and hygiene. The objective of this paper is to analyze the effects of social advertising campaign on the Clean India Mission (Swachh Bharat Abhiyan) and to determine the degree of impact on citizens' behavior
The Impact of High-Contact Sports on Memory and Auditory Comprehension in Young Athletes following Sports-Related Concussions
Authors: Yoo Hyunsoo , Taylor Bess-Sirmon
Published: September 2023

Purpose: we investigated whether memory and language abilities differ by sports played (football, basketball, and ice hockey) following Sport-Related Concussions (SRCs).Methods: A total of 74 young athletes with mild TBI were enrolled in this study and all participants specifically from Sports-Related Concussions. The group of 74 participants with mTBI from SRCs was divided into three groups by the sports played: football (N=35), basketball (N=19), and ice hockey (N=20).Results: The Multivariate Analysis of Variance (MANOVA) was conducted on the two selected variables, verbal memory composite scores and CRTT-Efficiency Scores. The results of the MANOVA demonstrated that there were no significant differences across three sports group.Conclusions: The primary goal of the current study was to investigate whether measurement of cognitivelinguistic function across three different high-contact sports showed significant differences on young athletes’ memory and language performance following sport-related concussions (SRCs). The results revealed that verbal memory and auditory comprehension at a sentence level were not statistically significantly different across three main high-contact sports following SRCs.
Contribution of foodstuffs contained radionuclides to formation of internal radiation doses received in areas Bryansk region affected by the Chernobyl accident
Authors:   National Research Nuclear University MEPhI, Panov A.V. , Komarova L.N. ,   National Research Nuclear University MEPhI, Lyapunova E.R. ,   National Research Nuclear University MEPhI, Mel’nikova A.A. ,   National Research Nuclear University MEPhI
Published: September 2023

The authors review current specific features of internal radiation doses received by people resided in 135 urban and rural settlements in six south-western districts of the Bryansk region affected by the Chernobyl accident. The residents received the average annual radiation dose > 1 mSv. The Cs-137 radioactivity contained in local agricultural and natural food was evaluated with the account of the dietary structure. Comparative analysis of long-term data on a contribution of local food contained radionuclides to the population, estimated by the average annual effective dose of internal radiation was carried out. Potatoes and pork taken from the private farms in the settlements under survey met health and hygiene standards for different levels of Cs-137 in 2022. However, there was a risk of exceeding the sanitary hygiene’s requirements for Cs-137 specific radioactivity in milk from privately-owned farms located in 89% of the settlements under survey, in 98% of beef produced in the farms and in 100% of mushrooms collected in forests near these settlements. Currently, the main dose-forming product is milk (contribution to the internal exposure dose is 60%), a smaller role in dose formation is in mushrooms (about 20%) and a minimal dose is in potatoes and meat (10% each). Over the past 20 years, the contribution of milk to the internal exposure dose has increased by 15-20%, and the contribution of mushrooms has decreased because of changes in the diet of the rural population of the Bryansk region and due to the reduction and redistribution of local products in the food basket.
A method for assessing the radiation risk of medical exposure after computed tomography scan of children and adolescents based on data from scanning protocols
Authors:   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC), Kashcheev V.V. , Pryakhin E.A. ,   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC), Menyailo A.N. ,   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC)
Published: September 2023

Computed tomography (CT) scan is a fairly accurate and reliable method for diagnosing various diseases, however, based on irradiation of the patient with ionizing radiation, it can lead to an excess risk of developing malignant neoplasms. According to the safety standards of the International Atomic Energy Agency, no patient can be exposed to medical radiation unless he or she has been informed of the risks associated with radiation exposure. This requirement is also contained in the Russian Radiation Safety Standards (NRB-99/2009). Radiation risk is estimated on the basis of calculated values of equivalent doses in the patient's organs and tissues using radiation risk models of the International Commission on Radiological Protection. This article is devoted to the improvement of the method for calculating equivalent doses in the organs and tissues of patients with computed tomography scan for further assessment of radiation risks. For 15 modern computed tomography scanners, with different geometry of patient scanning, the data necessary for calculating the equivalent doses in organs and tissues based on the parameters of the children's phantom were updated. The coefficients of conversion of the surrogate measure of the patient's radiation dose for the entire CT scan study, namely, the value of the "Dose Length Product" (DLP), into the values of equivalent doses in individual organs and tissues exposed to radiation were determined. The results of the calculation are given for five typical scan areas: chest, abdomen, pelvis, head and neck. In the course of simulation numerical modeling, organs and tissues with the highest equivalent doses were determined during CT scan examinations of children and adolescents. Unlike adult patients, for children and adolescents, the dose load on the surface of the bone is significantly lower and does not stand out in any of the considered types of CT scan examinations. It should be noted that with CT scan of the cervical spine, due to the specifics of the geometry of scanning new types of tomography scanners, the dose load on the thyroid gland of boys increased. The dose conversion factors obtained in this paper with estimates of standard deviations make it possible to assess the radiation risks of children and adolescents during examinations on modern CT scanners and optimize their dose loads.
Evaluation of permissible level of soluble I-131 containing fission products for design of protective measures in livestock industry
Authors:   Russian Institute of Radiology and Agroecology, Sarukhanov V.Ya. , Epimakhov V.G. ,   Russian Institute of Radiology and Agroecology
Published: September 2023

Among soluble radioactive products of uranium nuclear fission entering a body iodine radioisotopes are the main radiation hazards. The impact of iodine radioisotopes selectively accumulated by the thyroid on a body depends on absorbed radiation dose to the gland, they can cause hypothyroidism or athyreosis. Athyreosis of non-radiation origin is characterized by metabolism decline, fatigue, bradycardia, cessation of hair growth, roughness of the skin, alopecia, reduced animal productivity with increased fat deposition and possible death of embryos in the initial stages of pregnancy. Therefore veterinary service has the opportunity and time to arrange the necessary activities in order to minimize adverse impact of the fission byproducts on dairy cattle in territories contaminated with radionuclides. Thyroid irradiation at a dose of 100 Gy does not cause impairment of cows reproductive traits. The animals can bring full-fledged offspring, their further use should be decided after the examination by veterinary service. Irradiation of the thyroid gland of heifers at a dose of 30 Gy resulted in phase changes in thyroid hormone levels. Subsequent studies of the animals hormonal status demonstrated a recovery trend. No changes in immunological reactivity and productivity were observed in animals. It was found that absorbed radiation dose to the thyroid below 30 Gy did not cause disturbance of hormonal status of animals. This thyroid dose of a cow was registered after the introduction of 333 MBq of I-131. This activity corresponds to the activity of 5,000 MBq/animal of the different radioisotopes accumulated during 10-hours of uranium nuclear fission. Similar safe doses were obtained in an experiment on lactating cows, received 6,475 MBq/animal. If the contribution of iodine radioisotopes to the total activity of soluble uranium fission products is known, it is possible to assess the appropriateness to start the dairy cattle grazing soon after the accident.
Novel stability conditions for some generalization of Nicholson's blowflies model with stochastic perturbations
Authors: Shaikhet Leonid , Abbas Syed
Published: September 2023

We consider a generalization of the well-known nonlinear Nicholson blowflies model with stochastic perturbations. Stability in probability of the positive equilibrium of the considered equation is studied. Two types of stability conditions: delay-dependent and delay-independent conditions are obtained, using the method of Lyapunov functionals and the method of linear matrix inequalities. The obtained results are illustrated by numerical simulations by means of some examples. The results are new, and complement the existing ones.
 
doi: 10.1017/S1446181123000147
Numerical simulations for largely deformed beams and rings adopting a nontensile smoothed particle hydrodynamics algorithm
Authors: Tran-Duc Thien , Meylan Michael , Thamwattana Natalie
Published: September 2023

Three typical elastic problems, including beam bending, truss extension and compression, and two-rings collision are simulated with smoothed particle hydrodynamics (SPH) using Lagrangian and Eulerian algorithms. A contact-force model for elastic collisions and equation of state for pressure arising in colliding elastic bodies are also analytically derived. Numerical validations, on using the corresponding theoretical models, are carried out for the beam bending, truss extension and compression simulations. Numerical instabilities caused by largely deformed particle configurations in finite/large elastic deformations are analysed. The numerical experiments show that the algorithms handle small deformations well, but only the Lagrangian algorithm can handle large elastic deformations. The numerical results obtained from the Lagrangian algorithm also show a good agreement with the theoretical values.
 
doi: 10.1017/S1446181123000160
Exact solutions of hyperbolic reaction-diffusion equations in two dimensions
Authors: Broadbridge Phil , Goard Joanna
Published: September 2023

Exact solutions are constructed for a class of nonlinear hyperbolic reaction-diffusion equations in two-space dimensions. Reduction of variables and subsequent solutions follow from a special nonclassical symmetry that uncovers a conditionally integrable system, equivalent to the linear Helmholtz equation. The hyperbolicity is commonly associated with a speed limit due to a delay, \(\tau\), between gradients and fluxes. With lethal boundary conditions on a circular domain wherein a species population exhibits logistic growth of Fisher–KPP type with equal time lag, the critical domain size for avoidance of extinction does not depend on \(\tau\). A diminishing exact solution within a circular domain is also constructed, when the reaction represents a weak Allee effect of Huxley type. For a combustion reaction of Arrhenius type, the only known exact solution that is finite but unbounded is extended to allow for a positive \(\tau\).
 
doi: 10.1017/S1446181123000093
A Series of Personalized Virtual Light Therapy Interventions for Fatigue: Feasibility Randomized Crossover Trial for N-of-1 Treatment
Authors: Butler Mark , D’Angelo Stefani , Ahn Heejoon , Chandereng Thevaa , Miller Danielle , Perrin Alexandra , Romain Anne-Marie N , Scatoni Ava , Friel Ciaran P , Cheung Ying-Kuen , Davidson Karina W
Published: September 2023

Background

Fatigue is one of the most common symptoms treated in primary care and can lead to deficits in mental health and functioning. Light therapy can be an effective treatment for symptoms of fatigue; however, the feasibility, scalability, and individual-level heterogeneity of light therapy for fatigue are unknown.

Objective

This study aimed to evaluate the feasibility, acceptability, and effectiveness of a series of personalized (N-of-1) interventions for the virtual delivery of bright light (BL) therapy and dim light (DL) therapy versus usual care (UC) treatment for fatigue in 60 participants.

Methods

Participants completed satisfaction surveys comprising the System Usability Scale (SUS) and items assessing satisfaction with the components of the personalized trial. Symptoms of fatigue were measured using the Patient-Reported Outcomes Measurement Information System (PROMIS) daily, PROMIS weekly, and ecological momentary assessment (EMA) questionnaires delivered 3 times daily. Comparisons of fatigue between the BL, DL, and UC treatment periods were conducted using generalized linear mixed model analyses between participants and generalized least squares analyses within individual participants.

Results

Participants rated the usability of the personalized trial as acceptable (average SUS score=78.9, SD 15.6), and 92% (49/53) of those who completed satisfaction surveys stated that they would recommend the trial to others. The levels of fatigue symptoms measured using the PROMIS daily fatigue measure were lower or improved in the BL (B=−1.63, 95% CI −2.63 to −0.63) and DL (B=−1.44, 95% CI −2.50 to −0.38) periods relative to UC. The treatment effects of BL and DL on the PROMIS daily measure varied among participants. Similar findings were demonstrated for the PROMIS weekly and EMA measures of fatigue symptoms.

Conclusions

The participant scores on the SUS and satisfaction surveys suggest that personalized N-of-1 trials of light therapy for fatigue symptoms are both feasible and acceptable. Both interventions produced significant (P<.05) reductions in participant-reported PROMIS and EMA fatigue symptoms relative to UC. However, the heterogeneity of these treatment effects across participants indicated that the effect of light therapy was not uniform. This heterogeneity along with high ratings of usability and satisfaction support the use of personalized N-of-1 research designs in evaluating the effect of light therapy on fatigue for each patient. Furthermore, the results of this trial provide additional support for the use of a series of personalized N-of-1 research trials.

Trial Registration

ClinicalTrials.gov NCT04707846; https://clinicaltrials.gov/ct2/show/NCT04707846
Methodological Considerations for a Diabetes Family-Based eHealth Intervention (Preprint)
Authors: Brož Jan , Campbell Matthew D , Krollová Pavlína , Michalec Juraj
Published: September 2023

UNSTRUCTURED
Characterizing and Comparing Adverse Drug Events Documented in 2 Spontaneous Reporting Systems in the Lower Mainland of British Columbia, Canada: Retrospective Observational Study (Preprint)
Authors: Lau Erica Y , Cragg Amber , Small Serena S , Butcher Katherine , Hohl Corinne M
Published: September 2023

BACKGROUND

Robust adverse drug event (ADE) reporting systems are crucial to monitor and identify drug safety signals, but the quantity and type of ADEs captured may vary by system characteristics.

OBJECTIVE

We compared ADEs reported in 2 different reporting systems in the same jurisdictions, the Patient Safety and Learning System–Adverse Drug Reaction (PSLS-ADR) and ActionADE, to understand report variation.

METHODS

This retrospective observational study analyzed reports entered into PSLS-ADR and ActionADE systems between December 1, 2019, and December 31, 2022. We conducted a comprehensive analysis including all events from both reporting systems to examine coverage and usage and understand the types of events captured in both systems. We calculated descriptive statistics for reporting facility type, patient demographics, serious events, and most reported drugs. We conducted a subanalysis focused on adverse drug reactions to enable direct comparisons between systems in terms of the volume and events reported. We stratified results by reporting system.

RESULTS

We performed the comprehensive analysis on 3248 ADE reports, of which 12.4% (375/3035) were reported in PSLS-ADR and 87.6% (2660/3035) were reported in ActionADE. Distribution of all events and serious events varied slightly between the 2 systems. Iohexol, gadobutrol, and empagliflozin were the most common culprit drugs (173/375, 46.2%) in PSLS-ADR, while hydrochlorothiazide, apixaban, and ramipril (308/2660, 11.6%) were common in ActionADE. We included 2728 reports in the subanalysis of adverse drug reactions, of which 12.9% (353/2728) were reported in PSLS-ADR and 86.4% (2357/2728) were reported in ActionADE. ActionADE captured 4- to 6-fold more comparable events than PSLS-ADR over this study’s period.

CONCLUSIONS

User-friendly and robust reporting systems are vital for pharmacovigilance and patient safety. This study highlights substantial differences in ADE data that were generated by different reporting systems. Understanding system factors that lead to varying reporting patterns can enhance ADE monitoring and should be taken into account when evaluating drug safety signals.
DIVERSIFIKASI PANGAN DAN DIFERENSIASI POLA KONSUMSI PANGAN LOKAL RUMAHTANGGA TANI DI DESA BLEBERAN KECAMATAN PLAYEN KABUPATEN GUNUNGKIDUL
Authors: Sudrajat Sudrajat
Published: September 2023

Abstrak: Diversifikasi pangan  merupakan salah satu bentuk upaya manusia  untuk menganekaragamkan ketersedian pangan. Namun, pada kenyataan tidak semua manusia  mampu melakukan diversifikasi pangan, sehingga terjadilah diferensiasi pola konsumsi pangan.  Penelitian ini dilakukan dengan tujuan untuk mengkaji   diversifikasi pangan  dan   diferensiasi  pola  konsumsi pangan lokal pada rumahtangga tani, serta faktor yang mempengaruhinya. Penelitian ini dilakukan di Desa Bleberan Playen dengan mengambil sejumlah sampel rumahtangga tani secara random sampling. Pengumpulan data perimer dilakukan melalui wawancara dengan kepala rumahtangga tani meggunakan kusioner. Data dianalisis secara deskriptif dengan menggunakan  tabel frekuensi dan secara kuantitatif dengan uji statistic regresi liner berganda. Hasil penelitian menemukan, diversifikasi  produksi bahan pangan  maupun diversifikasi  olahan bahan pangan  yang dihasilkan rumahtangga tani sangat beragam dan tidak terlepas dari pengaruh  faktor demografi, social, budaya  maupun ekonomi. Penelitian ini juga menemukan, adanya diferensiasi pola konsumsi pangan pada rumahtangga tani, baik dlihat dari jenis, fekreuensi maupun jumlah bahan pangan yang dikonsumsi rumahtangga dalam periode waktu tertentu. Diferensiasi pola konsumsi pangan juga tidak terlepas dari pengaruh  faktor social-budaya  maupun  ekonomi.
Cómo se pensó Costa Rica. Imágenes e imaginarios en tarjetas postales 1900 - 1930
Authors: Camacho Navarro Enrique
Published: September 2023

Cómo se pensó Costa Rica. Imágenes e imaginarios en tarjetas postales: 1900-1930 es una obra que analiza el tema de las tarjetas postales, cuyo origen surgió en 1869, durante el Imperio austro-húngaro. Éstas eran un medio de comunicación, entre personas ubicadas e n lugares distantes, que de ser unas simples tarjetas de fácil manejo, en las que se escribía un mensaje breve, pasarían a convertirse en medios de comunicación ilustrados, llenos de imágenes que comprendían diferente aspectos relacionados con los lugares desde donde eran enviadas.
Heridas crónicas: retos y tratamientos
Authors: Flores-Merino Miriam V. , Flores Estrada Jaime , Domínguez García Ma. Victoria
Published: September 2023

Las personas en buen estado de salud no tienen problemas con los procesos de cierre de heridas; sin embargo, en el mundo existen millones de personas con heridas crónicas, las cuales son consecuencia de padecimientos complejos. Un ejemplo claro son los pacientes con diabetes mellitus, que a menudo sufren complicaciones como la úlcera diabética, la cual es producto del retraso del proceso normal de cicatrización. Actualmente, hay varias terapias que pueden ayudar en los procesos de cierre de heridas crónicas, que van desde los tratamientos más tradicionales, como el retiro de piel muerta, hasta aquellos que incluyen el uso de piel artificial o materiales avanzados. No obstante, estos últimos son tratamientos costosos y complejos, lo que los hace poco accesibles, especialmente en países en vías de desarrollo. Por ello, en este artículo se abordan los retos relacionados con los tratamientos principales para las heridas crónicas.
La mujer novohispana en el mundo del libro
Authors: García Valente María de Lourdes
Published: September 2023

En la sociedad novohispana, sin importar su clase social, las mujeres se caracterizaban por ser sumisas y se les atribuía una debilidad y sometimiento de tipo patriarcal y confesional. La mujer con estatus económico alto tenía, en general, mejor vida que las menos favorecidas económicamente, incluso un mayor acceso a la cultura. Estas mujeres provenían de familias poseedoras de ranchos, haciendas o dedicadas al comercio; podían ser hijas de médicos, pintores, impresores, entre otros, pero aun así sus labores estaban limitadas por su sexo y a lo que su padre o marido decidieran para ellas; recibían una instrucción básica y eran educadas para casarse y educar a los hijos según los valores de su tiempo.
"Las revistas literarias y la configuración de las sociedades modernas". Fin de siglo porfirista: arte y política en la Revista Moderna (1898-1911)
Authors: Moncayo Ramírez Jonatan
Published: September 2023

Reseña de:Fin de siglo porfirista: arte y política en la Revista Moderna (1898-1911). Diana Hernández Suárez. Madrid: Editorial Verbum, 2021, 273 p. ISBN: 978-84-1337-663-9.
Evaluation of Lipid Profile of High Salt fed Rats treated with L-Arginine
Authors: Beshel Justin Atiang , Ashipu Justina Andornimye , Adie Paulicarp Umim , Beshel Favour Nyoh , Ujong Gabriel Otu
Published: September 2023

There is a global concern on salt consumption above the dietary guideline; salt consumption evokes physiological responses with cardiovascular risks associated with dyslipidemia other than increased blood pressure as numerous studies have pointed out. This study aimed at evaluating the effect of L-Arginine on lipid profile of rats fed high salt diet. Forty Male Albino Wister rats weighing between 70-120g were randomly selected assigned into four groups of 10 rats each. Group 1 served as the control and was given distilled water and normal rat chow. Group 2 was fed with high salt diet (8% Nacl in feed, and 1% Nacl in drinking water) Group 3 was treated as group 2 with the introduction of L-Arginine on the 43rd day of the experiment. Group 4 was treated as group 2 with the introduction of losartan administration on the 43rd day of the experiment. Administration of L-Arginine and losartan lasted for 14 days, making a total duration of feeding and drugs administration 56 days. At the end of the 56th day, the rats were fasted overnight for 12 hours and sacrificed under anaesthesia using sodium pentobarbitone. Blood samples were then collected from each animal via cardiac puncture into heparinized tubes and centrifuged at 3500rpm for a period of 15 min, and the clear supernatant plasma were collected and stored at -20°C for biochemical analyses of lipid profile. The results showed a significant increase in TG, LDL-C, TC, VLDL-C and a reduction of HDL-C in the salt fed group. Conversely, a significant reduction in TG, LDL-C, TC, VLDL-C and an increase in HDL-C was shown in the salt + L-Arginine treated group when compared to the control. The changes observed in the L-Arginine treated groups reversed the hyperlipidemia in the salt treated group which indicates L-Arginine is beneficial in treatment of salt induced dyslipidemia and cardiovascular diseases.
Keywords: cardiovascular risks, dyslipidemia, L-Arginine, rats fed high salt diet
Management of Radius and / Or Ulna Fracture by Screw Intramedullary Nail in Skeletally Mature Patients
Authors: Shah Dr. Parth , Dhaniwala Dr. Nareshkumar , Pandey Dr. Poornima
Published: September 2023

The standard nailing of both bone forearm fractures of the radius and ulna poses a possible complication of nail migration androtational instability, despite being one of the best reduction techniques. This study has strived to evaluate how effectively screw elasticintramedullary nail is useful in the therapy for mature diaphyseal fractures of both bone forearms. The issues faced with conventional nailingtechniques for managing forearm fractures have also been discussed. A prospective evaluation of twenty-one cases with forearm fractures (radiusand ulna or isolated fracture of the single bone) was done. Out of the twenty-one cases studied, eighteen patients had undergone closedreduction, and three cases required mini-open reduction. The fracture was categorized as claimed by Arbeitsgemeinschaft furOsteosynthesefragen (AO) Foundation/Orthopedic Trauma Association(OTA). The results were evaluated according to Anderson criteria, inwhich 13 cases had excellent results, 4 had good results, 3 had an unsatisfactory result, and 1 was reported as failure. Also, there was 1 case ofsynostosis and 1 case of delayed union in radius. We concluded that the intramedullary screw nail for forearm fractures in adults could be used asa good internal fixation therapy giving excellent functional and radiological results. This technique is easy to learn, and the implant used is alsocost-effective, thus, providing a good fixation of the fracture. The most accepted technique for forearm fracture, as per current recommendationand AO, are open reductions and internal fixation with plating, but our study is exclusive since it helped to overcome the failure of conventionalnailing of both forearm bones with the potential complication of nail migration and rotational instability in spite the best reduction.
Concept of Sangyaharana (Anaesthesia) and Pain Management in Ayurveda: A Critical Review
Authors: Sharma Dr. Shivam , Asutkar Dr. Sheetal
Published: September 2023

Despite highly developed scientific studies, pain continues to be the leading cause of disability that affects a sizable portion of theglobal population. An integrated approach to pain management may alleviate the distress associated with treating this symptom, which can bepresent in various degrees. The Sushruta Samhita is the only complete work that addresses the difficulties of actual surgery and midwifery.Sushruta was a deeply skilled surgeon. Since the beginning, doctors have recognized the importance of anesthesia and have worked to createthis pain-free surgical environment. Sushruta utilized Sangyaharana for painless surgery. The Sushruta Samhita is where we first see asystematic approach to organizing the surgical expertise of more experienced surgeons. Some dravyas, such as Madya (wine), have beendescribed by Sushruta, while mohachurna has been discussed in Bhojaprabandha. According to Charaka, the tikshna sura should beadministered to the patient before surgery. Some study experts have also detailed the use of Ayurvedic medications, including Vacha,Ashwagandha, Bramhi, Parijata, and Parasika yavani, postoperatively to reduce pain, edema, and anxiety in patients.A major herbal anestheticis still needed, though. This review provides a historical overview of the Sangyaharana (Anaesthesia) practiced by ancient surgeons. Thisarticle highlights the concept of sangyaharana (anesthesia) and pain management in Ayurveda. The main objective of this article was to collectdata from different articles and textual concepts and present it systematically. This review article covers a combination of all the drugs andayurvedic herbal methods for sangyaharana and pain management. Most previous articles had very little information about the drugs andmethods of sangyaharn, and the data was very discrete and in random order. This article covers all the details in a systematic and orderlymanner. This article provides information regarding various Ayurvedic treatment modalities for pain management. It also shows the need foran effective Ayurvedic anesthetic drug having sangyaharan properties in the present era, and scientists and researchers have to work on thison a priority basis. The article concludes with how the sangyaharna was given in old times and old literature about sangyaharna and drugs thathelp pain management in pre-sangyaharna and their work in the modern era.
Rehabilitación en la enfermedad de Pompe
Authors: Jaramillo-Herrera Diana Patricia
Published: September 2023

Introducción: gracias a la nueva herramienta de tratamiento con la terapia de reemplazo enzimático en la enfermedad de Pompe, se ha reducido la mortalidad a corto plazo.
Contenidos: esta herramienta permite a los pacientes mantener la independencia funcional y la adaptación de las habilidades motrices para su participación en varios aspectos de la vida diaria.
Conclusiones: el abordaje de estos pacientes debe ser multidisciplinario, para dar un manejo integral a la condición clínica de cada individuo, y procurar el tratamiento de los sistemas físicos y emocionales que se pueden ver alterados con el curso de la enfermedad: osteomuscular, cardiovascular y respiratorio, deglución, lenguaje, nutrición y psicológico, incluidos los cuidados paliativos y el manejo del dolor.
Are urbanization and brood parasitism associated with differences in telomere lengths in song sparrows?
Authors: Lane Samuel , Vernasco Ben , Fossett Taylor , VanDiest Isaac , Watts Heather E. , Sewall Kendra
Published: September 2023

Urbanization reflects a major form of environmental change impacting
wild birds globally. Whereas urban habitats may provide increased
availability of water, some food items, and reduced predation levels
compared to rural, they can also present novel stressors including
increased light at night, ambient noise, and reduced nutrient
availability. Urbanization can also alter levels of brood parasitism,
with some host species experiencing elevated levels of brood parasitism
in urban areas compared to rural areas. Though the demographic and
behavioral consequences of urbanization and brood parasitism have
received considerable attention, their consequences for cellular-level
processes are less understood. Telomeres provide an opportunity to
understand the cellular consequences of different environments as they
are a well-established metric of biological state that can be associated
with residual lifespan, disease risk, and behaviour, and are known to be
sensitive to environmental conditions. Here we examine the relationships
between urbanization, brood parasitism, and blood telomere lengths in
adult and nestling song sparrows (Melospiza melodia). Song sparrows are
a North American songbird found in both urban and rural habitats that
experience high rates of brood parasitism by brown-headed cowbirds
(Molothrus ater) in the urban, but not the rural, sites in our study
system. Among adults and nestlings from non-parasitized nests, we found
no differences in relative telomere lengths between urban and rural
habitats. However, among urban nestlings, the presence of a brood
parasite in the nest was associated with significantly shorter relative
telomere lengths compared to when a brood parasite was absent. Our
results suggest a novel, indirect, impact of urbanization on nestling
songbirds through the physiological impacts of brood parasitism.
Explainable AI Model as a Complementary Tool to Randomized Controlled Trials (RCTs): A Comprehensive Assessment using Historical COVID Data
Authors: Shetty Manu , Mozumdar Aaloke , Gupta Saurabh , Gupta Lalit , Chaudhary Kapil , Roy Vandana , Kumar Suresh , singh Bhupinder , E Sanjeev Khanth P , Gupta Anubha
Published: September 2023

Background and Purpose: Randomized Control Trials (RCTs) are the gold
standard for establishing causality in drug efficacy, However, they have
limitations due to strict inclusion criteria and complexity. When RCTs
are not feasible, researchers turn to observational studies. Explainable
AI (XAI) models provide an alternative approach to understanding
cause-and-effect relationships. Experimental Approach: : In this study,
we utilized an XAI model with a historical COVID-19 dataset to establish
the hypothesis of drug efficacy. The datasets consisted of 3,307
COVID-19 patients from a hospital in Delhi, India. Eight XAI models were
employed to assess factors influencing COVID-19 mortality. LIME and SHAP
interpretability techniques were applied to the best-performing ML model
to determine feature importance in outcome. Key Results: The XGBoost ML
classifier outperformed (weighted F1 score, MCC, accuracy, ROC-AUC,
sensitivity and specificity score of 91.7%, 58.8%, 91.3%, 92.2%
93.8%, and 70.2%, respectively) other models and the SHAP summary plot
enabled the identification of significant features that contributes to
COVID-19 mortality. These features encompassed comorbidities like renal
and cardiac diseases and tuberculosis. Additionally, the XAI models
revealed that medications such as enoxaparin, remdesivir, and ivermectin
did not exhibit preventive effects on mortality Conclusion and
Implications: While XAI models offer valuable insights, they should not
replace RCTs as a priority for ensuring the safety and effectiveness of
new drugs and treatments. However, XAI models can serve as valuable
tools for suggesting future research directions and aiding clinical
decision-making, particularly when the efficacy of a drug in a
controlled trial is uncertain.
Family typology for adults with type 2 diabetes: Longitudinal stability and validity for diabetes management and wellbeing
Authors: Mayberry Lindsay S. , Zhao Shilin , K. Roddy McKenzie , Spieker Andrew J. , Berg Cynthia A. , Nelson Lyndsay A. , Greevy Robert A.
Published: September 2023

Objective: We validated longitudinally a typology of diabetes-specific family functioning (Collaborative and Helpful, Satisfied with Low Involvement, Want More Involvement, Critically Involved) in adults with type 2 diabetes.

Research Design and Methods: We conducted k-means cluster analysis with nine dimensions to determine if the typology replicated in a diverse sample and type assignment was robust to variations in sampling and included dimensions. In a subsample with repeated assessments over 9 months, we examined stability and validity of the typology. We also applied a multinomial logistic regression approach to make the typology usable at the individual-level, like a diagnostic tool.

Results: Participants (N=717) were 51% male, over one-third reported minoritized race or ethnicity, mean age was 57 and mean HbA1c was 7.9% (63 mmol/mol) [8.7% (72 mmol/mol) for longitudinal subsample]. The typology replicated with respect to the number of types and dimension patterns. Type assignment was robust to sampling variations (97% consistent across simulations). Type had an average 52% stability over time within participants; instability was not explained by measurement error. Over 9 months, type was independently associated with HbA1c, diabetes self-efficacy, diabetes medication adherence, diabetes distress, and depressive symptoms (all p-values<0.05).

Conclusions: The typology of diabetes-specific family functioning replicated, and longitudinal analyses suggest type is more a dynamic state than stable trait. However, type varies with diabetes self-management and wellbeing over time as a consistent independent indicator of outcomes. The typology is ready to be applied to further precision medicine approaches to behavioral and psychosocial diabetes research and care.
Reliability and validity of the supine-to-stand test in people with stroke
Authors: Ng Shamay S.M. , Chen Peiming , Chan Tony C.W. , Chang Cherry H.L. , Cheng Regen H.Y. , Chow Kylie K.L. , Yeung Alex F.M. , Liu Tai-Wa , Ho Lily Y.W. , Yeung Jerry W.F. , Xu Richard H. , Tse Mimi M.Y.
Published: September 2023

Objective: To investigate the psychometric properties of the supine-to-stand test in people with stroke. Design: Cross-sectional design. Subjects: Fifty-two people with stroke (mean (standard deviation) age 63.13 (6.09) years; time post-stroke 93.13 (61.36) months) and 49 healthy older adults (61.90 (7.29) months). Methods: Subjects with stroke were recruited from the community dwelling in Hong Kong and  assessed with the supineto- stand test, Fugl-Meyer Motor Assessment, ankle muscle strength test, Berg Balance Scale, limit of stability test, Timed Up-and-Go Test, Six-Minute Walk Test, Chinese version of Activities-specific Balance Confidence scale, Community Integration Measure (CIM-C), and 12-item Short-Form Health Survey (SF-12) in a university-based rehabilitation laboratory. Results: The supine-to-stand test completion time demonstrated excellent intra-rater, inter-rater and test-retest reliability (intraclass correlation coefficient 0.946–1.000) for the people with stroke. The completion time was significantly negatively correlated with Berg Balance Scale, Six-Minute Walk Test, limit of stability – maximal excursion, and limit of stability – endpoint excursion results (r = –0.391 to –0.507), whereas it was positively correlated with the Timed Up-and-Go test results (r = 0.461). The optimal cut-off supine-to-stand test completion time of 5.25 s is feasible for a clinical measure to distinguish the performance of people with stroke from healthy older adults (area under the curve = 0.852, sensitivity = 81.1%, specificity = 84.0%). Conclusion: The supine-to-stand test is a reliable, sensitive, specific and easy-to-administer clinical test for assessing the supine-to-stand ability of people with stroke.
Clinical and Healthcare Impacts of Portable Ultrasonography in Ambulatory Care Musculoskeletal Rehabilitation Consultations
Authors: De la Lama Jose M. , Morales Manuel , De Nicolas Juan , Ucin Andrea , Galvan Antonio
Published: September 2023

Objective: Point-of-care ultrasound (POCUS) is increasingly used to evaluate patients with musculoskeletal problems. Here we evaluated the impact of POCUS in musculoskeletal consultations in primary care setting using a Philips Lumify portable ultrasound device. We aimed to determine the impact of POCUS on the number of hospital referrals for therapeutic infiltrations as well as on the number of infiltrations performed in consultation. Design: This retrospective case study compared two periods: June to September 2021 (pre-POCUS) and November 2021 to February 2022 (POCUS). Statistical comparisons were performed using the chi-squared test. In both periods, 21 medical consultations were performed. In the pre-POCUS period, 470 patients were assessed, with average of 1.29 hospital referrals made per day for infiltration and average of 2.05 infiltrations performed per day during consultation. In the POCUS period, 589 patients were assessed, with an average of 0.1 hospital referrals per day (-92.6%; p<0.00001) and an average of 2.76 infiltrations performed per day during consultation (+34.9%; p<0.00001). The introduction of POCUS at our practice drastically reduced the number of referrals made for interventional techniques and increased the number of interventional procedures performed during consultations. Conclusion: This suggests that POCUS is of great clinical value in musculoskeletal rehabilitation consultations.
Incrusion of Bubonic Plague in the Rural Commune Andina
Authors: Razafindrakalia Mathilde
Published: September 2023

Introduction: Plague is a current scourge, despite the therapeutic evolution. In Africa, the DRC and Madagascar are the two countries that declare cases of plague: in 2018, 133 cases and 5 deaths in the DRC; 104 cases and 34 deaths in Madagascar. It is an infectious bacterial disease of wild rodents accidentally transmitted to humans by the infected fleas. It is a notifiable disease subject to international health regulations. Andina is one of the most active plagues in Madagascar. All people bitten by infected fleas can be sick without distribution according to social class. In view of these considerations, our objective aims to estimate the frequency of the plague, to describe its epidemiological, clinical and therapeutic aspects, and to evaluate the exposure of patients in the commune to the disease. Materials and Methods: On the one hand, we carried out a retrospective study in Andina by consulting the registered cases of the years 2013-2014. The diagnosis of plague was retained in 18 cases among the 31 cases recorded in the center. On the other hand, a survey on the housing of the patients was carried out. Results: The disease affected children under 15 (66.67% of cases). The female gender was predominant (61.11%). More than 51% of patients are febrile, including 69% with inguinal and axillary lymphadenopathy. More than 81% of clinical suspects were confirmed by the rapid diagnostic test and more than 44% of cases were treated with streptomycin, with 12% of cases dying during treatment. An additional survey was carried out to know the knowledge of the population which showed that 80% of people had heard of the plague and 60% recognized that deratting constitutes a means of preventive control of this disease. Conclusion: Plague management and surveillance have been improved following the possibility of rapid diagnosis in all CSB II, but the persistence of poverty plays a role in the maintenance of endemic outbreaks of this disease.