bluuebunny/crossref_metadata_2025 huggingface dataset:
India to envision One Health movement for confronting emerging health threats: From concept to approach toward institutionalization
Authors: Nambiar Prejit
Published: December 2020

The author's key role in advocating and leading One Health (OH) initiatives in India (especially in Kerala), review the need for and progress of OH from concept to approach and proposes its institutionalization as the way forward. India is currently facing many health threats such as antimicrobial resistance, environmental health hazards, and food safety risks and most importantly, zoonotic diseases such as Nipah, Avian Influenza, Scrub typhus, Congo fever, Kyasanur forest disease, COVID-19, and leptospirosis that grossly impact country's economy. The recent pandemics had exposed the gaps in public health policy and government is prepared to commit on the OH approach and to invest more on public health infrastructure. Further, as challenges have increased in recent years, OH approach was clearly advocated by the experts not only to cope up the pandemic but also to manage the infodemic by promoting the timely dissemination of accurate information. Right from the endorsement of OH in 2007 by India's Prime minister to the present fight against COVID-19 pandemic, the actions to control and manage the disease was ideally oriented toward a collaborative approach. Last year (2019), the representatives from relevant ministries and department had a ground-breaking dialog to develop charter and constitute a National policy on OH. Recently, Health Ministers of the Member States of the World Health Organization South-East Asia signed "Delhi declaration" where the key essence was to implement intersectoral coordination mechanisms following the "OH" approach. India's future policy intervention will emphasize on strengthening of integrated public health labs and contributing to building a national institutional platform for OH to boost research initiatives. Taking stock of OH happenings, resources, challenges, and priorities, the implementation strategy has been proposed across human, animal and environmental health. The article further highlights the key areas that need OH intervention in India, the country's progress in OH and the success stories of OH for a sustainable action to confront emerging health threats.
THE INFLUENCE OF THE FACTOR OF INDUSTRY AFFILIATION ON THE FINANCIAL STABILITY OF RESOURCE-SUPPLYING ORGANIZATIONS
Authors: Ilinykh Julia Mikhailovna , Aksenova Elena Alexandrovna
Published: December 2020

In determining the essence of the concept of financial stability of a company, the key point is to present the allowable amount of receivables and the maximum period of cash turnover in settlements with customers. The emerging tendency to reduce the turnover period contributes to an increase in the liquidity of the organization’s assets and, as a result, to an increase in its financial stability. The article discusses the features of the influence of the factor of industry affiliation on the level of receivables and financial stability of resource-supplying organizations; a number of recommendations for managing the factor in order to increase their financial stability is proposed.
Formalization of the informal venture capital market - Business angel networks and syndicates
Authors: Becsky-Nagy Patrícia , Novák Zsuzsanna
Published: December 2020

Business angels are natural persons who provide equity financing for young enterprises and gain ownership in them. They are usually anonym investors and they operate in the background of the companies. Their important feature is that over the funding of the enterprises based on their business experiences they can contribute to the success of the companies with their special expertise and with strategic support. As a result of the asymmetric information between the angels and the companies their matching is difficult (Becsky-Nagy – Fazekas 2015), and the fact, that angel investors prefer anonymity makes it harder for entrepreneurs to obtain informal venture capital. The primary aim of the different type of business angel organizations and networks is to alleviate this matching process with intermediation between the two parties. The role of these organizations is increasing in the informal venture capital market compared to the individually operating angels. The recognition of their economic importance led many governments to support them. There were also public initiations that aimed the establishment of these intermediary organizations that led to the institutionalization of business angels. This study via the characterization of business angels focuses on the progress of these informational intermediaries and their ways of development with regards to the international trends and the current situation of Hungarian business angels and angel networks.
Avaliação do ensino de habilidades de comunicação no currículo do 1º ao 8º período do curso de medicina da Universidade Federal de Juiz de Fora
Authors: Ezequiel Oscarina da Silva , Tibiriça Sandra Helena Cerrato , Langame Angélica de Paula , Santos Denise Junqueira dos , Afonso Denise Herdy
Published: December 2020

A comunicação, como competência nuclear na educação médica, tornou-se tema de interesse como campo de pesquisa e objeto de iniciativas de programas de ensino e avaliação. Seguindo as Diretrizes Curriculares Nacionais (DCN, 2014), o projeto pedagógico do curso de Medicina da UFJF (PPC, 2015) propõe uma formação baseada em competências, visando o atendimento integral do ser humano. Para o sucesso desta proposta, o desenvolvimento das habilidades de comunicação deve ser longitudinal. Assim, faz-se necessária a avaliação da situação atual e da demanda de alunos e professores quanto ao ensino dessas habilidades para posterior implantação deste componente curricular. Objetivos: Avaliar a situação atual e a demanda dos professores quanto ao ensino de habilidade de comunicação nos primeiros quatro anos do curso de medicina. Método: Pesquisa transversal, quali-quantitativa, aplicada e descritiva. Foi realizada a análise documental das DCN (2014), do PPC (2015) e dos programas das disciplinas do 1º ao 8º período e também a análise de questionário eletrônico aplicado aos 78 docentes responsáveis pelas disciplinas. Resultados: 27% dos programas das disciplinas mencionam o tema comunicação, sendo que as categorias mais frequentemente citadas foram registro dos dados, construção de vínculo e técnicas de entrevista médica, enquanto que as categorias compartilhamento de informações e comunicação interprofissional são as mais citadas nas DCN. 52% dos professores responderam os questionários e 91% concordam/concordam fortemente sobre a importância do ensino de habilidades de comunicação. Conclusão: Apesar da obrigatoriedade do ensino da comunicação no currículo médico e da concordância dos docentes quanto à sua relevância, somente um quarto das disciplinas trata do mesmo, revelando a inadequação dos programas às orientações das diretrizes.
Implementação do Programa Saúde na Escola no Colégio Municipal Pedro Amado – Petrópolis/RJ: um relato de experiência interdisciplinar
Authors: De Azevedo Rafaella Araújo , Marcolino Mariana Leal , Mathias Desirré , Curioni Raphael
Published: December 2020

O Programa Saúde na Escola (PSE) resulta do trabalho integrado entre o Ministério da Saúde e o Ministério da Educação, na perspectiva de ampliar as ações específicas de saúde aos alunos da rede pública de ensino, com a finalidade de contribuir para a formação integral dos estudantes por meio de ações de prevenção, promoção e atenção à saúde. Dessa forma, unem-se os setores saúde e educação, buscando o trabalho conjunto entre a equipe do Programa Saúde da Família e a equipe pedagógica da Escola. Relatar a experiência da equipe do PSF – Meio da Serra no Colégio Municipal Pedro Amado, ambos localizados no município de Petrópolis, com inicio em Junho de 2016, e ainda em andamento. O Programa deu-se inicio com a pactuação deste entre a equipe do PSF e a equipe pedagógica do Colégio, realizando-se o levantamento das necessidades e demandas. Em seguida, fez-se o planejamento da ação, definição do calendário das atividades, discussão dos temas que serão abordados e construção dos materiais que serão utilizados. Também foi realizada a apresentação do Programa para as famílias dos alunos e para a equipe pedagógica da escola. Os temas trabalhados foram: Higiene Corporal; Higiene Bucal; Promoção das práticas corporais e atividade física nas escolas; Promoção da cultura de paz e prevenção das violências; Ações de segurança alimentar e promoção da alimentação saudável; Educação para a saúde sexual, saúde reprodutiva e prevenção das DST/aids; Prevenção ao uso de álcool e tabaco e outras drogas; Promoção da saúde ambiental e desenvolvimento sustentável. Todas as temáticas foram tratadas de acordo com cada faixa etária, respeitando-se o nível de cognição, a linguagem e as particularidades sócio-culturais de cada grupo. As intervenções foram realizadas em conjunto pelos profissionais da UBS – Meio da Serra, (Residentes em Psicologia e Enfermagem, Enfermeira, Cirurgiã-Dentista, Técnica em Saúde Bucal, Técnica em Enfermagem, e Agentes Comunitárias de Saúde), com a participação dos docentes e discentes do Colégio, e com o apoio da Secretaria de Saúde de Petrópolis. Participaram ao todo cerca de 234 alunos, divididos em 10 turmas, que contemplam o 1º seguimento (Ensino Infantil ao 5ºano) e o 2º seguimento (6º ao 8º ano). Tem-se que o trabalho realizado, apesar de ainda não finalizado, uma vez que se busca a sua longitudinalidade, mostrou-se bem sucedido, visto que possibilitou a discussão de temáticas da saúde numa perspectiva ampla, de forma lúdica, horizontal e participativa. O PSE é um Programa que busca proporcionar aos jovens experiências de contato com temáticas poucas vezes trabalhadas em sala de aula, de forma lúdica, participativa, horizontalizada e integrativa. Assim, almeja-se uma aproximação da saúde na perspectiva da prevenção de doenças e agravos, e na promoção do bem-estar individual e comunitário e na qualidade de vida.
Controle social como cenário de prática da Residência Multiprofissional em Gestão de Políticas Públicas para a Saúde
Authors: Souza Antônio Alves de , Silva João Paulo Almeida Brito da , Raggio Armando Martinho Bardou , Passos Maria Fabiana Damásio
Published: December 2020

Introdução: A participação da comunidade foi imprescindível para a criação e o desenvolvimento do SUS. Assegurada na Constituição Federal e sendo diretriz estratégica deste, expressa-se na saúde por meio dos conselhos e conferências de saúde e se configura como importante espaço de formação da Residência Multiprofissional em Gestão de Políticas Públicas para a Saúde, na perspectiva de formar profissionais para o exercício de gestões mais democráticas e participativas. Objetivo: Apresentar a discussão do controle social como campo de prática da Residência Multiprofissional em Gestão de Políticas Públicas para a Saúde. Métodos: Relato da experiência institucional de atores da EFG no processo de construção pedagógica da Residência a partir das atividades desenvolvidas  junto aos espaços de controle social. Resultados: Dentre a construção do  projeto  pedagógico da residência, juntamente com a ESCS foi feita a leitura da importância do Controle Social na formação dos residentes. No primeiro trimestre da residência foram ofertadas a participação em conferências e reuniões dos Conselhos Regionais, Distrital e Nacional, cujos debates tem contribuído para a formação destes demonstrando que são importantes espaços para o amadurecimento e formação dos residentes como gestores de políticas públicas. Conclusões: A construção e gestão de políticas públicas devem ser constituídas em espaços democráticos e participativos e devem orientar todo o processo de formação dos profissionais de saúde residentes.
DEVELOPMENT OF A MINING SIMULATION MODEL FOR POTASSIUM ORE MINING PLANNING
Authors:   Perm National Research Polytechnic University, Berezniki Branch, Berezniki,  Perm region, Russian Federation, Zatonskiy A.V. , Yazev P.A. ,   Perm National Research Polytechnic University, Perm, Russian Federation
Published: December 2020

In this article, we show the importance of potash fertilizers produced by PJSC Uralkali, Berezniki, Perm Territory for agriculture and the economy in general. А process of potas¬sium ore underground mining is described from breaking up moment till transportation to the surface. An importance of production planning for the mining enterprise functioning is substantiated. Various levels of plan-ning, from a general production plan to a weekly and daily plans are described. The problem of such planning at PJSC Uralkali is in using only integral performance indicators, it leads to significant errors. It is proposed to use simulation modeling as a possible solution to the problem. Purpose of work. The purpose of this work is to develop a simulation model of mining operations, from the process of breaking and transporting ore to a conveyor-transport system, and to test model’s applicability for ore mining planning. Since the existing software has a number of limitations in applies to potash mines, a specialized object-oriented library allows modeling queuing systems, multi-agent and active systems is used as a basis for modeling. The limitations and as-sumptions of the model are described. Materials and methods. The model is igned as a determinis-tic automaton. The end point for ore mining process modeling is the transfer of ore to the unloading point, because further transportation of ore is not a limiting factor for mining. Conclusion. The spe-cial states of all objects of the system including mining combine – self-propelled car – unloading point and all possible transitions between them are described. A data from open sources is taken to check the adequacy of the model. Changes in the simulation results are investigated for various in-put parameters in the developed software. The simulation results are of a pulsating character due to the periodic execution of the harvester drive away. A productivity of the combine decreases with an increase in the distance traveled by a self-propelled car. The possibility of transition to a stochas-tic model is investigated. An expected decrease due to an increase in the downtime of the combine is shown. A conclusion about the applicability of the model to improve the quality of planning for un-derground potassium ore mining is made based on obtained data.
THE USE OF MATHEMATICAL METHODS OF DIAGNOSTICS AS A FACTOR OF EFFECTIVE MANAGEMENT OF A MEDICAL ORGANIZATION
Authors:   South Ural State University, Chelyabinsk, Russian Federation, Loginovskiy O.V. , Gilev D.V. ,   Ural Federal University named after the first President of Russia B.N. Yeltsin,  Ekaterinburg, Russian Federation
Published: December 2020

This article introduces the main mathematical methods of diagnosis of diseases. At first, based on the study of the issue, it is concluded that the task of diagnostics is the most important task for the implementation of effective activities of any medical institution. Methods. Further, in the theoretical part, the main diagnostic models are formulated, such as discriminant analysis and taxonomy (cluster analysis). Then methods of discriminant analysis are applied for the diagnostic system, which allow reducing the medical problem to a system of linear inequalities, using the meth-od of decomposition of the function by basic functions. Results. At the end of the article, important conclusions are made that iterative methods for solving this problem are grouped mainly around the linear correction method, and final methods are grouped around the simplex method. The issue of using decision rule collectives in application packages is also discussed. Further, as a practical part, we consider the application of the described methods to a specific medical task, namely, the diagnosis of primary headaches by signs. To solve the problem, we construct the decisive rules that are the result of discriminant analysis. For these purposes, the Committee method is enabled, and other methods are used in comparison with it. The results show better predictive power for the Committee method. Conclusion. In the conclusion the author about kind of the specifics of mana¬gement of medical institutions, and highlighted the criterion of a correct and timely diagnosis – as one of the main, lets talk about the efficiency of management from the point of view of public health that is Central to an integrated approach of evaluating the effectiveness of medical organiza-tions.
METHODOLOGY OF SYSTEM MODELING OF ADAPTIVE MANAGEMENT OF MACHINE-BUILDING PRODUCTION
Authors:   Ufa State Aviation Technical University, Ufa, Russian Federation, Kulikov G.G. , Rechkalov A.V. ,   United Engine Corporation JSC, Moscow, Russian Federation, Artyukhov A.V. ,   United Engine Corporation JSC, Moscow, Russian Federation
Published: December 2020

The Model Paradigm of digital control in production systems is based on the intelligent integra-tion of virtual and real processes with production objects (their system models). In this case, the platform (environment) for the intelligent integration of virtual and real processes is the information environment of the subject-oriented area. The functions of specialists, in this case, are reduced to the role of experts who implement the formal predicate knowledge prescribed in the corresponding methods and job descriptions (documents) and analyze the updated data of real production from the corresponding databases and knowledge bases. This ensures the properties of identifiability and traceability of production facilities and their processes. The spatial and temporal distribution of the holding's production facilities determine the basic coordinate system for their system modeling and management. Automation of intellectual processes of organization, planning, monitoring and management of interconnected production facilities in space and time, taking into account the in-fluence of the external environment, in real and virtual aspects, is an important and urgent task. System modeling is one of the main components of the organization of any process, including pro-duction. It should also be noted that the system modeling process itself is an intellectual, laborious and ob-jective process. Purpose of the study. To develop a methodology for system modeling (system de-scription) and adaptive management of production activities by individual enterprises as part of a machine-building holding. Develop a methodology for implementing this system model. Research methods used in the work: – principles of system engineering methodology (process approach, life cycle, etc.); – an integrated approach and structural analysis of the diversity of information processes in the interaction of individual production enterprises within the holding; – functional modeling of dynamic systems. Results. A methodology of system modeling (system description) of multilevel adaptive control of production systems distributed in space and time is proposed, taking into account the influence of the external environment. On the example of a machine-building holding, it is shown that this in-tellectualized system dynamic model can be implemented in the form of an Information-Advisory System. Conclusion. The proposed Methodology of System Analysis and Modeling of Adaptive Mana¬gement of Machine-Building Production as a part of the holding allows solving urgent prob-lems of effective management of production activities, taking into account the influence of the ex-ternal environment.
MECHANISMS OF THE EFFECT OF TRADITIONAL MASSAGE ON CENTRAL AND PERIPHERAL CIRCULATION IN ADOLESCENT FEMALES INVOLVED IN RUNNING SPORTS
Authors: Sabiryanov A , Sabiryanova E , Sashenkov S , Izarovskaia I
Published: December 2020

Aim. The paper aims to analyze the effect of traditional massage on functional recovery of the cardiovascular system in adolescent females involved in running sports. Materials and methods. A 10-day traditional back and neck massage program was used as a recovery technique. The indicators of the central and peripheral circulation, the time and frequency characteristics of the heart rate, as well as finger pulse amplitude were obtained before and after the program. Results. After traditional massage, adolescent females involved in running sports demonstrate a decrease in heart rate, which is associated with a decrease in sympathoadrenal regulation of chronotropic heart function (a decrease in VLF, a decrease in the amplitude of dominant VLF and LF harmonics). Regression and canonical analysis shows that heart rate dependence of the activity of regulation levels changes. There is an increase in peripheral blood circulation and a decrease in blood pressure associated with both humoral and metabolic factors and a decrease in sympathoadrenal influences, which is confirmed by an analysis of pulse amplitude variability. It is shown that the dynamics of the time and frequency characteristics of VLF range is a marker of physiological changes in blood circulation after massage therapy. Conclusion. The effect of traditional massage on the blood circulation of adolescent females involved in running sports is associated with adaptation to massage effects and is manifested by changes in the neurohumoral regulation of hemodynamics.
The CO2/CH4 Separation Potential of ZIF-8/Polysulfone Mixed Matrix Membranes at Elevated Particle Loading for Biogas Upgradation Process
Authors: Sutrisna Putu Doddy , Hadi Ronaldo Pangestu , Siswanto Jonathan , Prabowo Giovanni J
Published: December 2020

Biogas is a renewable energy that has been explored widely in Indonesia to substitute non-renewable energy. However, the presence of certain gas, such as carbon dioxide (CO2), can decrease the calorific value and generate greenhouse gas. Hence, the separation of CO2 from methane (CH4) occurs as a crucial step to improve the utilization of biogas. The separation of CH4/CO2 can be conducted using a polymeric membrane that needs no chemical, hence considered as an environmentally friendly technique. However, the utilization of polymeric membrane in gas separation processes is hampered by the trade-off between gas throughput and selectivity. To solve this problem, the incorporation of inorganic particles, such as Zeolitic Imidazolate Framework-8 (ZIF-8) particles, into the polymer matrix to improve the gas separation performance of the membrane has been conducted recently. In this research, ZIF-8 has been incorporated into Polysulfone matrix to form ZIF-8/Polysulfone-based membrane by simple blending and phase inversion techniques in flat sheet configuration. The pure gas permeation tests showed an increase in gas permeability (26 Barrer compared to 17 Barrer) after the inclusion of ZIF-8 particles with a slight decrease in CO2/CH4selectivity for particle loading more than 15wt. %. Therefore, the membrane with 15wt. % of particles showed the best performance in terms of gas selectivity. This result was due to the aggregation of ZIF-8 particles at particle loading higher than 15wt. %. Chemical analysis indicated an interaction between filler and polymer, and there were increases in the degree of crystallinity after the incorporation of ZIF-8.
Kesantunan Berbahasa dalam Whatsapp di Lingkungan Rukun Tetangga
Authors: Astuti Sri Puji
Published: December 2020

The purpose of this study is to reveal the politeness maxim of what is obeyed and the maxim of what is violated in the Whatsapp group of PKK RT 04 RW XXIII Kelurahan Meteseh, Kecamatan Tembalang, Semarang. This research data is a piece of discourse taken from the group Whatsapp messages by choosing the topic of commemorating the 74th Anniversary of the Independence of the Republic of Indonesia. Once the data is collected, it is then analyzed by using linguistic politeness theory. Based on the results of the study, communication via Whatsapp of the PKK group complied with six maxims. Obedience to these six maxims causes a more harmonious relationship between group members. In addition to obeying the sixth maxim, this Whatsapp group also violates the maxim of wisdom and the maxim of sympathy that was aimed at humor.
Florence: a Web-based Grammar of Graphics for Making Maps and Learning Cartography
Authors: Poorthuis Ate , Van der Zee Lucas , Guo Grace , Keong Jo Hsi , Dy Bianchi
Published: December 2020

Online, web-based cartography workflows use a dizzying variety of software suites, libraries, and programming languages. This proliferation of mapmaking technologies, often developed from a software engineering rather than a cartographic foundation, creates a series of challenges for cartography education, research, and practice.

To address these challenges, we introduce a JavaScript-based open-source framework for web-based cartography and data visualization. It is built on top of existing open web standards that are already in intensive use for online mapmaking today, but provides a framework that is firmly based on cartographic and visualization theory rather than software engineering concepts. Specifically, we adopt concepts from Bertin’s Semiology of Graphics and Wilkinson’s Grammar of Graphics to create a language with a limited number of core concepts and verbs that are combined in a declarative style of “writing” visualizations. In this paper, we posit a series of design guidelines that have informed our approach, and discuss how we translate these tenets into a software implementation and framework with specific use cases and examples. We frame the development of the software and the discussion specifically in the context of the use of such tools in cartography education.

With this framework, we hope to provide an example of a software for web-based data visualization that is in sync with cartographic theories and objectives. Such approaches allow for potentially greater cartographic flexibility and creativity, as well as easier adoption in cartography courses.
Estimating population average treatment effects from experiments with noncompliance
Authors: Ottoboni Kellie N. , Poulos Jason V.
Published: December 2020

Randomized control trials (RCTs) are the gold standard for estimating causal effects, but often use samples that are non-representative of the actual population of interest. We propose a reweighting method for estimating population average treatment effects in settings with noncompliance. Simulations show the proposed compliance-adjusted population estimator outperforms its unadjusted counterpart when compliance is relatively low and can be predicted by observed covariates. We apply the method to evaluate the effect of Medicaid coverage on health care use for a target population of adults who may benefit from expansions to the Medicaid program. We draw RCT data from the Oregon Health Insurance Experiment, where less than one-third of those randomly selected to receive Medicaid benefits actually enrolled.
Cocaine-Dependent Acquisition of Locomotor Sensitization and Conditioned Place Preference Requires D1 Dopaminergic Signaling through a Cyclic AMP, NCS-Rapgef2, ERK, and Egr-1/Zif268 Pathway
Authors: Jiang Sunny Zhihong , Sweat Sean , Dahlke Sam P. , Loane Kathleen , Drossel Gunner , Xu Wenqin , Tejeda Hugo A. , Gerfen Charles R. , Eiden Lee E.
Published: December 2020

Elucidation of the mechanism of dopamine signaling to ERK that underlies plasticity in dopamine D1 receptor-expressing neurons leading to acquired cocaine preference is incomplete. NCS-Rapgef2 is a novel cAMP effector, expressed in neuronal and endocrine cells in adult mammals, that is required for D1 dopamine receptor-dependent ERK phosphorylation in mouse brain. In this report, we studied the effects of abrogating NCS-Rapgef2 expression on cAMP-dependent ERK→Egr-1/Zif268 signaling in cultured neuroendocrine cells; in D1 medium spiny neurons of NAc slices; and in either male or female mouse brain in a region-specific manner. NCS-Rapgef2 gene deletion in the NAc in adult mice, using adeno-associated virus-mediated expression of cre recombinase, eliminated cocaine-induced ERK phosphorylation and Egr-1/Zif268 upregulation in D1-medium spiny neurons and cocaine-induced behaviors, including locomotor sensitization and conditioned place preference. Abrogation of NCS-Rapgef2 gene expression in mPFC and BLA, by crossing mice bearing a floxed Rapgef2 allele with a cre mouse line driven by calcium/calmodulin-dependent kinase IIα promoter also eliminated cocaine-induced phospho-ERK activation and Egr-1/Zif268 induction, but without effect on the cocaine-induced behaviors. Our results indicate that NCS-Rapgef2 signaling to ERK in dopamine D1 receptor-expressing neurons in the NAc, but not in corticolimbic areas, contributes to cocaine-induced locomotor sensitization and conditioned place preference. Ablation of cocaine-dependent ERK activation by elimination of NCS-Rapgef2 occurred with no effect on phosphorylation of CREB in D1 dopaminoceptive neurons of NAc. This study reveals a new cAMP-dependent signaling pathway for cocaine-induced behavioral adaptations, mediated through NCS-Rapgef2/phospho-ERK activation, independently of PKA/CREB signaling.

SIGNIFICANCE STATEMENTERK phosphorylation in dopamine D1 receptor-expressing neurons exerts a pivotal role in psychostimulant-induced neuronal gene regulation and behavioral adaptation, including locomotor sensitization and drug preference in rodents. In this study, we examined the role of dopamine signaling through the D1 receptor via a novel pathway initiated through the cAMP-activated guanine nucleotide exchange factor NCS-Rapgef2 in mice. NCS-Rapgef2 in the NAc is required for activation of ERK and Egr-1/Zif268 in D1 dopaminoceptive neurons after acute cocaine administration, and subsequent enhanced locomotor response and drug seeking behavior after repeated cocaine administration. This novel component in dopamine signaling provides a potential new target for intervention in psychostimulant-shaped behaviors, and new understanding of how D1-medium spiny neurons encode the experience of psychomotor stimulant exposure.
The economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in Germany
Authors: Schaffner Monika , Rochau Ursula , Mühlberger Nikolai , Conrads-Frank Annette , Qerimi Rushaj Vjollca , Sroczynski Gaby , Koukkou Eftychia , Thuesen Betina Heinsbaek , Völzke Henry , Oberaigner Wilhelm , Siebert Uwe
Published: December 2020

Objective

More than 30% of the German population suffers from mild to moderate iodine deficiency causing goiter and other iodine deficiency disorders (IDDs). The economic burden of iodine deficiency is still unclear. We aimed to assess costs for prevention, monitoring and treatment of IDDs in Germany.

Design

We performed a comprehensive cost analysis.

Methods

We assessed direct medical costs and direct non-medical costs for inpatient and outpatient care of IDDs and costs for productivity loss due to the absence of work in 2018. Additionally, we calculated total costs for an IDD prevention program comprising universal salt iodization (USI). We performed threshold analyses projecting how many cases of IDDs or related treatments would need to be avoided for USI to be cost-saving.

Results

Annual average costs per case in the year of diagnosis were € 211 for goiter/thyroid nodules; € 308 for hyperthyroidism; and € 274 for hypothyroidism. Average one-time costs for thyroidectomy were € 4184 and € 3118 for radioiodine therapy. Average costs for one case of spontaneous abortion were € 916. Annual costs of intellectual disability were € 14,202. In the German population, total annual costs for USI would amount to 8 million Euro. To be cost-saving, USI would need to prevent, for example, 37,900 cases of goiter/thyroid nodules.

Conclusion

USI potentially saves costs, if a minimum amount of IDDs per year could be avoided. In order to recommend the implementation of USI, a full health-economic evaluation including a comprehensive benefit-harm assessment is needed.
Alert to US physicians: DHEA, widely used as an OTC androgen supplement, may exacerbate COVID-19
Authors: Nyce Jonathan
Published: December 2020

Androgens play a fundamental role in the morbidity and mortality of COVID-19, inducing both the ACE-2 receptor to which SARS-CoV-2 binds to gain entry into the cell, and TMPRS22, the transmembrane protease that primes the viral spike protein for efficient infection. The United States stands alone among developed nations in permitting one androgen, oral DHEA, to be freely available OTC and online as a ‘dietary supplement’. DHEA is widely used by males in the US to offset the age-related decline in circulating androgens. This fact may contribute to the disparate statistics of COVID-19 morbidity and mortality in this country. In regulatory antithesis, every other developed nation regulates DHEA as a controlled substance. DHEA is an extremely potent inhibitor of glucose-6-phosphate dehydrogenase (G6PD), with uniquely unstable uncompetitive inhibition kinetics. This has particular relevance to COVID-19 because G6PD-deficient human cells have been demonstrated to be exceptionally sensitive to infection by human coronavirus. Because DHEA is lipophilic and freely passes into cells, oral DHEA bypasses the normal controls regulating androgen biology and uncompetitive G6PD inhibition. DHEA’s status as a ‘dietary supplement’ means that no clinical trials demonstrating safety have been performed, and, in the absence of physician supervision, no data on adverse events have been collected. During the current pandemic, the unrestricted availability of oral DHEA as a ‘dietary supplement’ cannot be considered safe without proof from placebo-controlled clinical trials that it is not contributing to the severity of COVID-19. US physicians may therefore wish to query their patients’ use of DHEA.
Métricas de autor Ruth Alejandra Patiño Jacinto
Authors: Camilo Alejandro Corchuelo Rodriguez , Cristian Alexander Vega Mosquera , Luz Marina Paez
Published: December 2020

Informe de las métricas de autor de la Dra. Ruth Alejandra Patiño Jacinto de las publicaciones indexadas en Google Académico cuyo objetivo es entregar un insumo para el fortalecimiento de las capacidades y potencialidades de los autores de la Universidad Santo Tomás en el posicionamiento y visibilidad de sus publicaciones
Panel Internacional de expertos en Actividad Física para la Salud Ciclo: Actividad Física en casa. El juego en casa para mantener activos a nuestros niños, niñas y familias
Authors: Cindy Joulieth Castro Ramírez , Johanna Ruiz González , Nathaly Ospino , Patricia Traslaviña Espitia
Published: December 2020

El juego en casa para mantener activos a nuestros niños, niñas y familias, socializó las reflexiones y contextualización de los beneficios del juego durante el confinamiento, su vivencia plena en marco de la practica recreativa de las familias y algunas experiencias aplicadas como: Saltar en la cama, romper las reglas para jugar en la casa durante la cuarentena y el Festival de juegos en casa. El confinamiento, que ha desencadenado la pandemia del COVID-19, ha generado un punto de encuentro entre los niños y niñas con sus padres y familias, en el cual, el juego se convierte en una práctica de actividad física recurrente que beneficia la salud física, emocional y social; resignificando así el sentido del juego desde las posibilidades de ser y estar en la experiencia genuina de la práctica recreativa que nos invita al disfrute desde la dimensión lúdica como actitud ante la vida
Reabsorción radicular externa asociada al tratamiento ortodóncico: revisión de la literatura
Authors: Torres-Pinto Daniela Alejandra , Álvarez-Parker María Catalina
Published: December 2020

La reabsorción radicular externa (RRE) se define como la destrucción del cemento o la dentina por la actividad cementoblástica u osteoclástica, dando como resultado un acortamiento de la raíz al ser sometida a una fuerza ortodóncica. Aproximadamente un 80% de los pacientes presentan algún grado de reabsorción.  Esta condición tiene una gran variabilidad individual y su etiología es multifactorial por lo que esta revisión de literatura tiene como propósito entregar información sobre el proceso de reabsorción radicular y sus factores de riesgo para poder prevenir o intervenir oportunamente este efecto indeseado.  Para llevar a cabo este estudio se utilizaron bases de datos como Pubmed, Scielo, Wiley, Elsevier, teniendo como límite de búsqueda artículos publicados entre 2010 y 2020, a excepción de tres estudios, uno del 2005, del año 2007 y otro del año 2009, que proporcionaron información de suma relevancia sobre los factores de riesgo del fenómeno estudiado.  La reabsorción radicular externa es una complicación prevalente y actualmente no existe un consenso para manejar este proceso, es por esto, que es necesario estudios sistemáticos que proporcionen evidencia más confiable para que tanto ortodoncistas como otros especialistas tengan más conocimiento del tema evitando complicaciones tanto en el diagnóstico como durante el tratamiento al realizar movimientos dentales.
Piedras de toque en castros de Galicia y Asturias
Authors: Villa Valdés Ángel
Published: December 2020

Entre el repertorio de materiales líticos recuperados en los castros del noroeste peninsular se identifican nueve piezas dadas a conocer por sus descubridores o por los museos donde se exponen como piedras de toque, herramientas singulares vinculadas con la manipulación y transformación de metales preciosos aparecidas en horizontes de la Edad del Hierro o de temprana implantación romana. En este trabajo se describen las piezas conocidas así como sus contextos de procedencia.
Dominae: grandes propietarias de tierras en la Hispania romana
Authors: Castelo Ruano Raquel , López Pérez Ana María
Published: December 2020

A lo largo de estas líneas podremos observar la capacidad de la mujer hispanorromana para poseer tierras y ostentar sus derechos como propietaria. Algunas de ellas alcanzaron un gran protagonismo y fueron muy influyentes, tanto desde el punto de vista político como desde el punto de vista religioso.
Experimentación arqueológica con lucernas de época romana: usos y funcionalidad
Authors: Ramos Sainz Mª Luisa
Published: December 2020

Por medio de la arqueología experimental se han investigado diversos aspectos del uso y funcionalidad de las lucernas en época romana: los diferentes tipos de aceites empleados como combustible, las diversas fibras vegetales o animales utilizadas para la elaboración de las mechas, la morfología de las lucernas para conocer su uso, cómo se aviva la llama, cómo se recarga el aceite o para qué sirven los diversos orificios que presentan, etc. Así mismo se han realizado experimentos en torno a la iluminación, observando su duración y ventajas respecto al uso de velas. Por último se ha investigado sobre las labores cotidianas que podían llegar a realizarse con la luz que emitían las lucernas, y se ha valorado el número de lámparas que eran necesarias para iluminar adecuadamente una estancia.
Constitution and Preservation: Experiences of the Grand Duchy of Lithuania
Authors: Kuolys Darius
Published: December 2020

By refering to the examples of different cultural traditions, Arūnas Sverdiolas in his study Constitution and Preservation described the mechanisms that are involved in the creation of culture – constitution and preservation. The goal of this article is to show how these mechanisms operated in the reality of the Grand Duchy of Lithuania. The article analyzes the roles that the Lithuanian political society gave to legislation, upbringing, historical narratives, heroic and occasional poetry while constituting and preserving itself.
Space, Place, Haven: Levinas’s Phenomenology of Home
Authors: Saldukaitytė Jolanta
Published: December 2020

By distinguishing between space and place, the article situates and analyses the meaning of the closest place – home – in the philosophy of Emmanuel Levinas. The effort to encounter transcendence, to escape, to leave, to not be attached a particular place, and not to be driven by a nostalgia to return, is dominant in Levinas’s philosophy. This article shows that dwelling in a place, as settling in a home, also has a positive meaning for Levinas. This positive meaning comes, however, not from an ontological but from an ethical relationship with a place. The home is shown as chosen place, warm and human, as opposed to a given or natural place. On the one hand, the home is a necessary condition for security, but also the very condition of interiority and activity, of having the place in the world in contrast to thrownness. On the other hand, it is not a place where I is embodied and rooted in like a vegetable, but a place where I welcome the other.
Domain engineering approach of software requirements analysis
Authors:   National Aviation University, Chebanyuk O.V. , Palahin O.V. ,   Glushkov Institute of Cybernetics NAS of Ukraine, Markov K.K. ,   Institute of Information Theories and Applications Sofia, Bulgaria
Published: December 2020

Requirement analysis is one of the important processes in software development lifecycle management. In Agile approach requirements software models are the basic of generating other software development artifacts. Improving requirements approaches and techniques allows avoiding mistakes in other software development artifacts. Domain engineering fundamentals is the basic for “template oriented” approaches of software development artifacts designing. Reusing domain models and knowledge allows adding details in vertical “model to model” transformation operations, refine generated software development artifacts, organize systematic software reuse and perform many other activities. Paper proposes an approach of requirement analysis based on UML Use Case diagrams transformations into communication ones and the next refinements of them by means of information from domain models. The advantages of the proposed approach is the next: proposed transformation method involves ”many to many” transformation in order to save the semantic of initial model. Domain knowledge are used to complete communication diagram by means of adding details after transformation to them. In order to perform Use case to communication transformation graph representation of software models is chosen.
Elements of concrete algorithmics: computability and solvability
Authors:   Kiev Taras Shevchenko National University, Provotar O.I. , Provotar O.O. ,   Glushkov Institute of Cybernetics NAS of Ukraine
Published: December 2020

An approach to proving the fundamental results of the theory of recursive functions using specific algorithms is consider. For this, the basic constructions of the algorithm are describing exactly and Church's thesis for more narrow classes of algorithmically computational functions is specified (concretized). Using this approach, the belonging of functions to classes of algorithmically computable is argued by the construction of the corresponding algorithms.
Experience of the semantic technologies use for intelligent Web encyclopedia creation (on example of the Great Ukrainian Encyclopedia portal)
Authors:   Institute of Software Systems NAS of Ukraine, Andon P.I. , Rogushina J.V. ,   Institute of Software Systems NAS of Ukraine, Grishanova I.Yu. ,   Institute of Software Systems NAS of Ukraine, Reznichenko V.A. ,   Institute of Software Systems NAS of Ukraine, Kyridon A.M. ,   State Scientific Institution "Encyclopedic Publishing House", Aristova A.V. ,   State Scientific Institution "Encyclopedic Publishing House", Tishchenko A.O. ,   State Scientific Institution "Encyclopedic Publishing House"
Published: December 2020

We consider the conceptual principles of the Great Ukrainian Encyclopedia development and analyze the main advantages of its portal version – e-VUE. This portal version requires the relevant technological platform with high-level expressiveness and efficiency. Development of e-VUE with complex knowledge structure causes the study of modern Web-technologies and matching their capabilities with the specific requirements of encyclopedia. Therefore we consider in details the project idea and purposes, the specifics of e-VUE information representation (number and volume of articles, content types and sources, relations between content elements and their properties, business processes of article publication, design requirements) and processing (navigation, requests, integration and matching means) to estimate the Wiki-technology feasibility use (namely - opportunities and restrictions of MediaWiki technological platform). Also attention is paid to the means of information security ensuring and semantic-based establishment of content access rights. The results of such analysis show that MediaWiki with semantic plugins can be used as a base for e-VUE portal construction but needs in extension of its functionality based on modern knowledge management tools and formats of their interoperable representation. Now we are oriented on use of ontological analysis and Semantic Web standards (OWL, RDF, SPARQL). In terms of the Semantic Web, e-VUE is a distributed database with heterogeneous types of information objects that can be used both by humans and by external software (e.g. by intelligent agents). The main principles of e-VUE knowledge base organization are grounded on Wiki categories and semantic properties of Semantic MediaWiki that are used for formal representation of the e-VUE typical information objects (TIO). Such approach allows to express TIO relations, properties and characteristics that can be used by logical inference and semantic retrieval to improve the navigation between portal elements and integration of data from various Wiki pages.
Construction of diagnostic expert-medical system using neural networks
Authors:   National University ", Glybovets M.M. ,   Kyiv-Mohyla Academy", Salata K.V. ,   National University "Kyiv-Mohyla Academy", Tkach N.A. ,   Strazhesko Institute of Cardiology
Published: December 2020

In the article was discussed the methods (decision trees, deep learning algorithms, k-nearest neighbors, neural networks) to create diagnostic expert medical systems. For practice part were developed diagnostic API based on chosen classifiers that implement the algorithms and a study of their work was conducted. Namely, classifiers based on neural networks, decision trees and k-nearest neighbors method were compared. The parameters for the selected classifier were optimized. As a result, were selected parameters on which the data were researched. In addition, the dataset of information of patients who had heart attack was researched to develop a diagnostic system for revealing heart diseases. The diagnostic API for revealing patients’ heart diseases is described. Keywords: diagnostic systems, medical systems, neural networks, decision trees, diagnostic API.
Cluster Radioactivity
Authors: Poenaru D. N. , Gherghescu R. A.
Published: December 2020

Cluster radioactivity (spontaneous emission of heavy particles from nuclei) is presented from theoretical point of view in good agreement with experimental results. After a brief hystorical account we give details about the analytical super asymmetric fission (ASAF) model extensively used for predicting the half-lives of heavy and superheavy (Z ≥ 104) elements. For the already measured 26 cluster decays (from 14C to 32,34Si of parent nuclides with Z = 87-96) it is clear that cluster radioactivity is a rare phenomenon in the best case about 9 orders of magnitude weaker than the competing alpha decay. Then we show the theoretical possibility of a strong cluster decay compared to alpha decay for some superheavy nuclei with Z ≥ 122, e.g. 306122; 310-314122; 306-324124, and 311-323124.
Economic and Easy Do It Yourself (DIY) Safety Kit
Authors: Chauhan Yukta
Published: December 2020

The main objective of this paper is to present a cost effective and efficient safety kit in order to help fulfill the scarcity of PPE kits during COVID19 pandemic. These days it is quite essential to wear safety gears like masks, gloves, face shields etc. resulting in shortage of these items at some places and the second problem is that certain sections of people cannot afford to purchase these items. This paper presents methods to create cheap yet effective safety kits at home. The kit will require easily available material like cloth bag, biodegradable trash bag, polythene bag etc. and items like gown, cap, masks, and gloves can be made using these materials.