bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Characteristics and Long-term Outcomes in Diabetic Macular Edema Patients: With or without Additional Injection Following Ranibizumab Loading
Authors: Yoon Kyungwoo , Kim Eung Suk , Yu Seung-Young , Kim Kiyoung
Published: August 2022

Purpose: To investigate the baseline characteristics in patients with diabetic macular edema (DME) during 7 years according to the need for additional treatments after intravitreal ranibizumab (RBZ) loading injections.Methods: The medical records of 32 patients treated with intravitreal RBZ loading for DME during 7 years were reviewed. After three-consecutive monthly RBZ injections, additional treatment was decided according to the patient’s response to RBZ loading. Based on whether the patients received treatment with or without additional injections, including intravitreal antivascular endothelial factor or steroid injection, they were divided into the “no add (NA)” or “add” groups, respectively. The baseline best-corrected visual acuity (BCVA), macular volume (MV), central subfoveal thickness, and other clinical factors were analyzed, and their 7-year changes were compared between the two groups.Results: The BCVA of the NA group was better than that of the add group at 2, 3, 5, and 7 years (year 2, 3, and 5; p < 0.01, respectively). Baseline MV was significantly smaller in the NA group than in the add group (10.72 ± 0.88 μm vs. 11.98 ± 1.64 μm, p = 0.008). The DME duration before treatment in the NA group was significantly shorter than in the add group (1.03 ± 0.98 years vs. 1.91 ± 1.33 years, p = 0.042). The proportion of patients with serous retinal detachment or cystic macular edema was significantly lower in the NA group than in the add group (35.3% vs. 73.3%, p = 0.042). The NA group had smaller MV until 2 years than the add group (year 1, p = 0.002; year 2, p = 0.006).Conclusions: The DME pat﻿ients without additional treatments during 7 years after the initial loading treatment had shorter duration of DME and diffuse retinal thickening morphologic type with lower MV at baseline, and better long-term visual prognosis.
Recurrent Submandibular Gland Swelling Relieved by Antihistamine Medication: Is It Eosinophilic Sialodochitis?
Authors: Kim Do Hyung , Lee Sang Eun , Han Kang Min , Kim Bo Hae
Published: August 2022

Sialodochitis fibrinosa is a disease characterized by salivary duct obstruction. A 21-year-old male presented with a painful submandibular gland (SMG) swelling. Serum eosinophilia and Whartons’ duct dilatation with strong enhancement were observed on contrast CT. Core needle biopsy (CNB) for SMG parenchyma revealed lymphocytic infiltration between dilated intralobular ducts. In another case, a 39-year-old male complained of recurrent major salivary glands swelling for ten years with an itching sensation on the overlying skin of the salivary gland. Enhancement of both SMG parenchyma, dilatation of both Wharton’s ducts and elevated serum eosinophilia were observed on contrast CT study. CNB for SMG parenchyma revealed lymphocytic infiltration with many eosinophils around a markedly dilated interlobular duct. The recurrent SMG swelling in both cases were relieved by antihistamine medication, warranting suspicion that these cases might organ-specific eosinophilic disease. We dicuss these two cases with a literature review.
Impact of COVID-19 on pathophysiological changes on feto-maternal health and treatment strategies: A literature review
Authors: Hussain Hazera , Tabassum Tahsin , Tasmin Ruhina , Ahmed Kazi Ishraque , Joty Moshaffayata Jarin , Hayat Shahnaz , Khan Salma
Published: August 2022

Aim: During the coronavirus disease 2019 (COVID-19) pandemic, physiological changes in pregnancy have placed both the mother and the fetus at potential risk of infection. Particularly, changes in cardiovascular function, the coagulation cascade, the immune system, and the respiratory system may be instrumental in the COVID-19 disease progression. Since this is a novel virus, the management, treatment, and prevention of COVID-19 is still evolving in general and obstetric patients as well. Therefore, it has become very crucial to study its effect on pregnancy and how providers adapted new practices pragmatically without prior scientific data. Our goal is to focus on addressing these issues systematically. Methods: We selected all the peer-reviewed articles on pregnancy-related to COVID-19 infection. Search terms were COVID-19, coronavirus, pregnancy, and maternal health using google scholar, Centers for Disease Control and Prevention (CDC), and PubMed. Results: We demonstrated the direct and indirect impact of COVID-19 on maternal health, including physical, mental, and social effects. We primarily highlighted case series and cohort studies discussing the clinical course, management, pathophysiological (immunological) changes, and the outcomes of COVID-19 infection in pregnant women. Conclusion: We discussed the physiological, pathological, and mental health changes in pregnant women with COVID-19 infection and the current evolving management plans, treatment approaches, and preventive measures to combat the disease. A global effort in further research is essential to determine and minimize the impact of COVID-19 on pregnant women and their outcomes.
Judicial medical management of mild and minimal endometriosis in selected patients of infertility is non-inferior to surgical treatment – a retrospective analysis
Authors: Siddhartha Chatterjee , Bishista Bagchi , Arpan Chatterjee
Published: August 2022

Background: Endometriosis is an enigmatic disease that affects approximately 10% of women of reproductive age and almost 50% of women with endometriosis experience infertility. These women experience symptoms of dysmenorrhea, premenstrual pain, dyspareunia, and infertility, but many affected women are asymptomatic. Objective: To analyse the clinical pregnancy rate after treating mild and minimal endometriosis causing infertility with dienogest (2 mg) or by surgical intervention. Materials and Methods: 146 subfertile women with mild and minimal endometriosis, enrolled over a period of 36 months (January 2017 to December 2019) at Calcutta Fertility Mission have been included in the present study. They were grouped in A and B and treated with dienogest (2mg) for 90days or by laparoscopic ablation, and ovulation induction. Clinical pregnancy rates were analysed. Results: In our study, 18.52% of patients with early stage asymptomatic endometriosis, had conceived spontaneously after treatment with dienogest for 3 months, and 37.04%, 44.44% had conceived after treating them with dienogest followed by letrozole and letrozole and GnRH, for subsequent 3-6months, respectively. 13.64% , 36.36% , 50% of women had conceived spontaneously after laparoscopic ablation, after treating them with ablative procedure and letrozole and with letrozole and GnRH in the next 3-6 cycles, respectively. Spontaneous pregnancy and pregnancy following letrozole only or letrozole and GnRH in Group A and B were also not statistically significant (p - 0.961, p - 0.698). Conclusion: Clinical pregnancy in infertile women with early endometriosis treated with dienogest is non-inferior to others treated with laparoscopic ablation and minimal adhesiolysis.
Interaction between N6-methyladenosine and autophagy in the regulation of bone and tissue degeneration
Authors: Wen Xiaodong , Wang Junhu , Wang Qiong , Liu Peilong , Zhao Hongmou
Published: August 2022

Bone and tissue degeneration are the most common skeletal disorders that seriously affect people’s quality of life. N6-methyladenosine (m6A) is one of the most common RNA modifications in eukaryotic cells, affecting the alternative splicing, translation, stability and degradation of mRNA. Interestingly, increasing number of evidences have indicated that m6A modification could modulate the expression of autophagy-related (ATG) genes and promote autophagy in the cells. Autophagy is an important process regulating intracellular turnover and is evolutionarily conserved in eukaryotes. Abnormal autophagy results in a variety of diseases, including cardiomyopathy, degenerative disorders, and inflammation. Thus, the interaction between m6A modification and autophagy plays a prominent role in the onset and progression of bone and tissue degeneration. In this review, we summarize the current knowledge related to the effect of m6A modification on autophagy, and introduce the role of the crosstalk between m6A modification and autophagy in bone and tissue degeneration. An in-depth knowledge of the above crosstalk may help to improve our understanding of their effects on bone and tissue degeneration and provide novel insights for the future therapeutics.
Novel advances in strategies and applications of artificial articular cartilage
Authors: Chen Yifei , Zhang Chenyue , Zhang Shiyong , Qi Hexu , Zhang Donghui , Li Yifei , Fang Jie
Published: August 2022

Artificial articular cartilage (AC) is extensively applied in the repair and regeneration of cartilage which lacks self-regeneration capacity because of its avascular and low-cellularity nature. With advances in tissue engineering, bioengineering techniques for artificial AC construction have been increasing and maturing gradually. In this review, we elaborated on the advances of biological scaffold technologies in artificial AC including freeze-drying, electrospinning, 3D bioprinting and decellularized, and scaffold-free methods such as self-assembly and cell sheet. In the following, several successful applications of artificial AC built by scaffold and scaffold-free techniques are introduced to demonstrate the clinical application value of artificial AC.
A novel AIRE mutation leads to autoimmune polyendocrine syndrome type-1
Authors: Qian Guofeng , Yan Xiaoyi , Xuan Junli , Zheng Danfeng , He Zhiwen , Shen Jianguo
Published: August 2022

Autoimmune polyendocrine syndrome type-1 (APS-1) is a rare inherited monogenic autoimmune disease characterized by the presence of at least two of three following major clinical features: chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency. Mutations in autoimmune regulator (AIRE) gene have been found to contribute to APS-1. In the present study, we reported a 36-years-old male APS-1 patient who presented with hypoparathyroidism and Addison’s disease. The proband underwent complete clinical examinations and mutation screening was performed by Sanger sequencing on AIRE gene. A novel homozygous mutation in exon 9 of the AIRE gene (c.1024C>T) was identified. Based on sequencing findings, HEK293T cell-based assays were conducted to analyze the subcellular localization and mutant transcript processing. Our results revealed that p.Q342X mutant localized in nuclear speckles and exerted a dominant-negative effect on wildtype AIRE function. We reported the c.1024C>T mutation of AIRE gene for the first time, which enriched the AIRE mutation database and contributed to further understanding of APS-1.
Influence of sire fertility status on conceptus-induced transcriptomic response of the bovine endometrium
Authors: O’Callaghan E. , Sánchez J.M. , Rabaglino M.B. , McDonald M. , Liu H. , Spencer T.E. , Fair S. , Kenny D.A. , Lonergan P.
Published: August 2022

The aim was to examine the effect of sire fertility status on conceptus-induced changes in the bovine endometrial transcriptome. To generate elongated conceptuses, Day 7 blastocysts produced in vitro using frozen-thawed sperm from Holstein Friesian bulls (3 High fertility, HF and 3 Low fertility, LF) were transferred in groups of 5–10 into synchronized heifers (n = 7 heifers per bull) and recovered following slaughter on Day 15. Day 15 endometrial explants recovered from the uterine horn ipsilateral to the corpus luteum were recovered from synchronized cyclic heifers (n = 4). Explants from each heifer were co-cultured for 6 h in RPMI medium alone (Control) or with 100 ng/ml ovine recombinant interferon tau (IFNT) or with a single conceptus from each HF or LF bull. After 6 h, explants were snap frozen and stored at −80°C. Extracted mRNA was subjected to RNA-seq and the resulting data were analyzed with R software. The numbers of differentially expressed genes (DEG; FDR<0.05) were: HF vs. Control: 956; LF vs. Control: 1021; IFNT vs. Control: 1301; HF vs. LF: 2. Unsurprisingly, the majority of DEG (658) were common to all comparisons and were related to IFNT-induced changes in the endometrium. Prior to applying the adjusted p-value, there were 700 DEG between HF and LF, with 191 and 509 genes more expressed in HF or LF, respectively (p < 0.05). Overrepresentation analysis of KEGG pathways (FDR<0.05), revealed that DEG with higher expression in LF were involved in cell cycle and proteolysis, while those upregulated DEG by HF conceptuses were strongly associated with immune process pathways, such as TNF, NF-kappa B, cytokine-cytokine receptor interaction, and TLR signaling. These pathways were also enriched by DEG upregulated by IFNT compared to the Control. Furthermore, only the HF, and not the LF group, affected the expression of most genes in these pathways (p < 0.05) according to a negative binomial regression model. Finally, a weighted gene co-expression network analysis revealed two clusters of co-expressed genes associated with the HF conceptuses (p < 0.05), which were also enriched for the aforementioned pathways. In conclusion, HF conceptuses, similar to IFNT treatment, stimulated multiple pathways involved in immune response, which were apparently not affected by LF conceptuses.
Combined dehydrogenation of glycerol with catalytic transfer hydrogenation of H2 acceptors to chemicals: Opportunities and challenges
Authors: Zhang Guangyu , Zhao Jian , Jin Xin , Qian Yanan , Zhou Mingchuan , Jia Xuewu , Sun Feng , Jiang Jie , Xu Wei , Sun Bing
Published: August 2022

Catalytic transformation of low-cost glycerol to value-added lactic acid (LA) is considered as one of the most promising technologies for the upgradation of glycerol into renewable products. Currently, research studies reveal that anaerobic transformation of glycerol to LA could also obtain green H2 with the same yield of LA. However, the combined value-added utilization of released H2 with high selectivity of LA during glycerol conversion under mild conditions still remains a grand challenge. In this perspective, for the first time, we conducted a comprehensive and critical discussion on current strategies for combined one-pot/tandem dehydrogenation of glycerol to LA with catalytic transfer hydrogenation of H2 acceptors (such as CO2) to other chemicals. The aim of this overview was to provide a general guidance on the atomic economic reaction pathway for upgrading low-cost glycerol and CO2 to LA as well as other chemicals.
Recent progress of photocatalysts based on tungsten and related metals for nitrogen reduction to ammonia
Authors: Hui Xiangchao , Wang Lijun , Yao Zhibo , Hao Leiduan , Sun Zhenyu
Published: August 2022

Photocatalytic nitrogen reduction reaction (NRR) to ammonia holds a great promise for substituting the traditional energy-intensive Haber–Bosch process, which entails sunlight as an inexhaustible resource and water as a hydrogen source under mild conditions. Remarkable progress has been achieved regarding the activation and solar conversion of N2 to NH3 with the rapid development of emerging photocatalysts, but it still suffers from low efficiency. A comprehensive review on photocatalysts covering tungsten and related metals as well as their broad ranges of alloys and compounds is lacking. This article aims to summarize recent advances in this regard, focusing on the strategies to enhance the photocatalytic performance of tungsten and related metal semiconductors for the NRR. The fundamentals of solar-to-NH3 photocatalysis, reaction pathways, and NH3 quantification methods are presented, and the concomitant challenges are also revealed. Finally, we cast insights into the future development of sustainable NH3 production, and highlight some potential directions for further research in this vibrant field.
Divergent Cryptosporidium species and host-adapted Cryptosporidium canis subtypes in farmed minks, raccoon dogs and foxes in Shandong, China
Authors: Wang Weijian , Wei Yanting , Cao Shuhui , Wu Wenjie , Zhao Wentao , Guo Yaqiong , Xiao Lihua , Feng Yaoyu , Li Na
Published: August 2022

Cryptosporidium spp. are common parasitic pathogens causing diarrhea in humans and various animals. Fur animals are widely farmed in Shandong Province, China, but the prevalence and genetic identity of Cryptosporidium spp. in them are unclear. In this study, 1,211 fecal samples were collected from 602 minks, 310 raccoon dogs and 299 foxes on two farms in Shandong and analyzed for Cryptosporidium spp. by nested PCR and sequence analyses of the small subunit rRNA gene. The overall infection rate of Cryptosporidium spp. was 31.5% (381/1,211), with a higher infection rate in raccoon dogs (37.7%, 117/310) than in foxes (32.4%, 97/299) and minks (27.7%, 167/602). By age, the highest infection rates of Cryptosporidium spp. were observed in raccoon dogs of 1-2 months, minks of 5-6 months, and foxes of > 12 months. Three Cryptosporidium species and genotypes were detected, including C. canis (n = 279), C. meleagridis (n = 65) and Cryptosporidium mink genotype (n = 37). Among the three major host species, raccoon dogs were infected with C. canis only (n = 117), while foxes were infected with both C. canis (n = 32) and C. meleagridis (n = 65), and minks with C. canis (n = 130) and Cryptosporidium mink genotype (n = 37). Subtyping of C. canis by sequence analysis of the 60 kDa glycoprotein gene identified eight subtypes. They belonged to two known subtype families, XXa and XXd, and two novel subtype families XXf and XXg, with host adaptation at the subtype family level. Notably, C. canis from foxes was genetically distant from those in other hosts. Further subtyping analysis identified three subtypes (IIIeA21G2R1, IIIeA19G2R1 and IIIeA17G2R1) of C. meleagridis and two novel subtype families Xf and Xg of the Cryptosporidium mink genotype. The presence of zoonotic C. canis subtypes in raccoon dogs and C. meleagridis subtypes in foxes suggests that these fur animals might be potential reservoirs for human-pathogenic Cryptosporidium spp.
Convolutional kernel function algebra
Authors: Stow Edward , Kelly Paul H. J.
Published: August 2022

Many systems for image manipulation, signal analysis, machine learning, and scientific computing make use of discrete convolutional filters that are known before computation begins. These contexts benefit from common sub-expression elimination to reduce the number of calculations required, both multiplications and additions. We present an algebra for describing convolutional kernels and filters at a sufficient level of abstraction to enable intuitive common sub-expression based optimizations through decomposing filters into smaller, repeated, kernels. This enables the creation of an enormous search space of potential implementations of filters via algebraic manipulation. We demonstrate how integral image and sliding window optimizations can be expressed in the context of common sub-expression elimination as well as show the direct use case for this algebra in massively SIMD multiply-free contexts such as in cellular processor arrays. We then show that this algebra is general enough to express and optimize kernels that use non-standard semi-rings to enable shortest path algorithms.
Echocardiography-based AI detection of regional wall motion abnormalities and quantification of cardiac function in myocardial infarction
Authors: Lin Xixiang , Yang Feifei , Chen Yixin , Chen Xiaotian , Wang Wenjun , Chen Xu , Wang Qiushuang , Zhang Liwei , Guo Huayuan , Liu Bohan , Yu Liheng , Pu Haitao , Zhang Peifang , Wu Zhenzhou , Li Xin , Burkhoff Daniel , He Kunlun
Published: August 2022

Objective

To compare the performance of a newly developed deep learning (DL) framework for automatic detection of regional wall motion abnormalities (RWMAs) for patients presenting with the suspicion of myocardial infarction from echocardiograms obtained with portable bedside equipment versus standard equipment.

Background

Bedside echocardiography is increasingly used by emergency department setting for rapid triage of patients presenting with chest pain. However, compared to images obtained with standard equipment, lower image quality from bedside equipment can lead to improper diagnosis. To overcome these limitations, we developed an automatic workflow to process echocardiograms, including view selection, segmentation, detection of RWMAs and quantification of cardiac function that was trained and validated on image obtained from bedside and standard equipment.

Methods

We collected 4,142 examinations from one hospital as training and internal testing dataset and 2,811 examinations from other hospital as the external test dataset. For data pre-processing, we adopted DL model to automatically recognize three apical views and segment the left ventricle. Detection of RWMAs was achieved with 3D convolutional neural networks (CNN). Finally, DL model automatically measured the size of cardiac chambers and left ventricular ejection fraction.

Results

The view selection model identified the three apical views with an average accuracy of 96%. The segmentation model provided good agreement with manual segmentation, achieving an average Dice of 0.89. In the internal test dataset, the model detected RWMAs with AUC of 0.91 and 0.88 respectively for standard and bedside ultrasound. In the external test dataset, the AUC were 0.90 and 0.85. The automatic cardiac function measurements agreed with echocardiographic report values (e. g., mean bias is 4% for left ventricular ejection fraction).

Conclusion

We present a fully automated echocardiography pipeline applicable to both standard and bedside ultrasound with various functions, including view selection, quality control, segmentation, detection of the region of wall motion abnormalities and quantification of cardiac function.
Isoprenaline modified the lipidomic profile and reduced β-oxidation in HL-1 cardiomyocytes: In vitro model of takotsubo syndrome
Authors: Fiserova Ivana , Trinh Minh Duc , Elkalaf Moustafa , Vacek Lukas , Heide Marek , Martinkova Stanislava , Bechynska Kamila , Kosek Vit , Hajslova Jana , Fiser Ondrej , Tousek Petr , Polak Jan
Published: August 2022

Recent studies have suggested a pathogenetic link between impaired mitochondria and Takotsubo syndrome (TTS), which is closely connected with catecholamine overstimulation, poor outcomes, and changes in lipid metabolism. We investigated the changes in lipid metabolism at the level of fatty acid β-oxidation and changes in the intracellular lipidomic spectrum. The immortalized cell line of HL-1 cardiomyocytes was used in this study as an established in vitro model of TTS. The cells were exposed to the non-selective β-agonist isoprenaline (ISO) for acute (2 h) and prolonged (24 h) periods. We investigated the impact on mitochondrial adenosine 5’-triphosphate (ATP) production and β-oxidation using real-time cell metabolic analysis, total lipid content, and changes in the lipidomic spectrum using high-performance liquid chromatography (HPLC) and mass spectrometry. Furthermore, modifications of selected lipid transporters were determined using real-time – polymerase chain reaction (RT-PCR) and/or Western blot techniques. By choosing this wide range of targets, we provide a detailed overview of molecular changes in lipid metabolism during catecholamine overstimulation. The present study demonstrates that acute exposure to ISO decreased ATP production by up to 42.2%, and prolonged exposure to ISO decreased β-oxidation by 86.4%. Prolonged exposure to ISO also increased lipid accumulation by 4%. Lipid spectrum analysis of prolonged exposure to ISO showed a reduced concentration of cardioprotective and an increased concentration of lipotoxic lipid molecules during long-term exposure. Decreased lipid utilization can lead to higher intracellular lipid accumulation and the formation of lipotoxic molecules. Changes in the lipid spectrum can induce pathophysiological signaling pathways leading to cardiomyocyte remodeling or apoptosis. Thus, changes in lipid metabolism induced by excessive doses of catecholamines may cause TTS and contribute to a progression of heart failure, which is at increased risk after a TTS episode.
A clinical study on relationship between visualization of cardiac fibroblast activation protein activity by Al18F-NOTA-FAPI-04 positron emission tomography and cardiovascular disease
Authors: Lyu Zhehao , Han Wei , Zhao Hongyue , Jiao Yuying , Xu Peng , Wang Yangyang , Shen Qiuyi , Yang Shuai , Zhao Changjiu , Tian Lin , Fu Peng
Published: August 2022

Objective

FAP plays a vital role in myocardial injury and fibrosis. Although initially used to study imaging of primary and metastatic tumors, the use of FAPI tracers has recently been studied in cardiac remodeling after myocardial infarction. The study aimed to investigate the application of FAPI PET/CT imaging in human myocardial fibrosis and its relationship with clinical factors.

Materials and methods

Retrospective analysis of FAPI PET/CT scans of twenty-one oncological patients from 05/2021 to 03/2022 with visual uptake of FAPI in the myocardium were applying the American Heart Association 17-segment model of the left ventricle. The patients’ general data, echocardiography, and laboratory examination results were collected, and the correlation between PET imaging data and the above data was analyzed. Linear regression models, Kendall’s TaU-B test, the Spearman test, and the Mann–Whitney U test were used for the statistical analysis.

Results

21 patients (60.1 ± 9.4 years; 17 men) were evaluated with an overall mean LVEF of 59.3 ± 5.4%. The calcific plaque burden of LAD, LCX, and RCA are 14 (66.7%), 12 (57.1%), and 9 (42.9%). High left ventricular SUVmax correlated with BMI (P < 0.05) and blood glucose level (P < 0.05), and TBR correlated with age (P < 0.05). A strong correlation was demonstrated between SUVmean and CTnImax (r = 0.711, P < 0.01). Negative correlation of SUVmean and LVEF (r = −0.61, P < 0.01), SUVmax and LVEF (r = −0.65, P < 0.01) were found. ROC curve for predicting calcified plaques by myocardial FAPI uptake (SUVmean) in LAD, LCX, and RCA territory showed AUCs were 0.786, 0.759, and 0.769.

Conclusion

FAPI PET/CT scans might be used as a new potential method to evaluate cardiac fibrosis to help patients’ management further. FAPI PET imaging can reflect the process of myocardial fibrosis. High FAPI uptakes correlate with cardiovascular risk factors and the distribution of coronary plaques.
Cardiogenic shock among cancer patients
Authors: Curtiaud Anais , Delmas Clement , Gantzer Justine , Zafrani Lara , Siegemund Martin , Meziani Ferhat , Merdji Hamid
Published: August 2022

Sophisticated cancer treatments, cardiovascular risk factors, and aging trigger acute cardiovascular diseases in an increasing number of cancer patients. Among acute cardiovascular diseases, cancer treatment, as well as the cancer disease itself, may induce a cardiogenic shock. Although increasing, these cardiogenic shocks are still relatively limited, and their management is a matter of debate in cancer patients. Etiologies that cause cardiogenic shock are slightly different from those of non-cancer patients, and management has some specific features always requiring a multidisciplinary approach. Recent guidelines and extensive data from the scientific literature can provide useful guidance for the management of these critical patients. Even if no etiologic therapy is available, maximal intensive supportive measures can often be justified, as most of these cardiogenic shocks are potentially reversible. In this review, we address the major etiologies that can lead to cardiogenic shock in cancer patients and discuss issues related to its management.
Lung ultrasound-guided treatment for heart failure: An updated meta-analysis and trial sequential analysis
Authors: Li Yan , Ai Hu , Ma Na , Li Peng , Ren Junhong
Published: August 2022

Background

The usefulness of lung ultrasound (LUS) in guiding heart failure (HF) treatment is still controversial.

Purpose

We aimed to evaluate the usefulness of LUS-guided treatment vs. usual care in reducing the major adverse cardiac event (MACE) rate in patients with HF.

Materials and methods

We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) identified through systematic searches of MEDLINE, EMBASE, the Cochrane Database, Google Scholar, and SinoMed. The primary outcome was MACEs (a composite of all-cause mortality, HF-related rehospitalization, and symptomatic HF). The required information size was calculated by trial sequential analysis (TSA).

Results

In total, ten RCTs involving 1,203 patients were included. Overall, after a mean follow-up period of 4.7 months, LUS-guided treatment was associated with a significantly lower risk of MACEs than usual care [relative risk (RR), 0.59; 95% confidence interval (CI), 0.48–0.71]. Moreover, the rate of HF-related rehospitalization (RR, 0.63; 95% CI, 0.40–0.99) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration (standardized mean difference, –2.28; 95% CI, –4.34 to –0.22) were markedly lower in the LUS-guided treatment group. The meta-regression analysis showed a significant correlation between MACEs and the change in B-line count (p < 0.05). The subgroup analysis revealed that the risk of MACEs was markedly lower in patients aged up to 70 years (RR, 0.54; 95% CI, 0.44–0.67), with a lower rate of atrial fibrillation (< 27.2%) (RR, 0.53; 95% CI, 0.43–0.67), and with a lower NT-proBNP concentration (< 3,433 pg/ml) (RR, 0.51; 95% CI, 0.40–0.64). TSA indicated a lower risk of MACEs with LUS-guided treatment than with usual care among patients with HF (p < 0.05).

Conclusion

Lung ultrasound seems to be a safe and effective method to guide HF treatment.

Systematic review registration

[https://inplasy.com/], identifier [INPLASY202220124].
Link between sterile inflammation and cardiovascular diseases: Focus on cGAS-STING pathway in the pathogenesis and therapeutic prospect
Authors: Du Yao , Zhang Hui , Nie Xiaoyan , Qi Yajun , Shi Shi , Han Yingying , Zhou Wenchen , He Chaoyong , Wang Lintao
Published: August 2022

Sterile inflammation characterized by unresolved chronic inflammation is well established to promote the progression of multiple autoimmune diseases, metabolic disorders, neurodegenerative diseases, and cardiovascular diseases, collectively termed as sterile inflammatory diseases. In recent years, substantial evidence has revealed that the inflammatory response is closely related to cardiovascular diseases. Cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway which is activated by cytoplasmic DNA promotes the activation of interferon regulatory factor 3 (IRF3) or nuclear factor-κB (NF-κB), thus leading to upregulation of the levels of inflammatory factors and interferons (IFNs). Therefore, studying the role of inflammation caused by cGAS-STING pathway in cardiovascular diseases could provide a new therapeutic target for cardiovascular diseases. This review focuses on that cGAS-STING-mediated inflammatory response in the progression of cardiovascular diseases and the prospects of cGAS or STING inhibitors for treatment of cardiovascular diseases.
Effect of preoperative pulse oximeter oxygen saturation on postoperative prolonged mechanical ventilation in patients with tetralogy of Fallot
Authors: Wu Xie , An Ran , Luo Qipeng , Li Yinan , Wang Hongbai , Liu Qiao , Huang Jiangshan , Jia Yuan , Yuan Su , Yan Fuxia
Published: August 2022

Background

As an easily accessible and intervened clinical indicator, preoperative pulse oximeter oxygen saturation (SpO2) is an important factor affecting the prognosis of patients with tetralogy of Fallot (TOF). However, whether SpO2 is associated with postoperative mechanical ventilation (MV) time remains unknown. Therefore, this study aimed to investigate the impact of preoperative SpO2 on postoperative prolonged mechanical ventilation (PMV) in children with TOF.

Materials and methods

The study included children younger than 18 years who underwent corrective operations for TOF between January 2016 and December 2018 in Fuwai Hospital, China. Univariate and multivariate logistic regression analyses were used to evaluate the influence of preoperative SpO2 on postoperative PMV. After identifying SpO2 as an independent risk factor for PMV, patients were further divided into two groups according to the cutoff value of SpO2, and propensity score matching (PSM) analysis was used to eliminate the effect of confounding factors. The logistic regression was used to compare the outcomes between the two groups after PSM.

Results

A total of 617 patients were finally enrolled in this study. By the univariable and multivariate logistic analysis, four independent risk factors for PMV were determined, namely, SpO2, surgical technique, aortic cross-clamp time, and intraoperative minimum temperature. According to the outcomes of 219 paired patients after PSM, the incidence of PMV was significantly higher in patients with lower preoperative SpO2 (P = 0.022). Also, there was significant increase in mechanical ventilation time (P = 0.019), length of intensive care unit stay (P = 0.044), postoperative hospital stay (P = 0.006), hospital stay (P = 0.039), and hospitalization cost (P = 0.019) at the lower preoperative SpO2 level.

Conclusion

Low preoperative SpO2 represents an independent risk factor of postoperative PMV in children with TOF.
Multi-parametric study of an eruptive phase comprising unrest, major explosions, crater failure, pyroclastic density currents and lava flows: Stromboli volcano, 1 December 2020–30 June 2021
Authors: Calvari S. , Di Traglia F. , Ganci G. , Bruno V. , Ciancitto F. , Di Lieto B. , Gambino S. , Garcia A. , Giudicepietro F. , Inguaggiato S. , Vita F. , Cangemi M. , Inguaggiato C. , Macedonio G. , Mattia M. , Miraglia L. , Nolesini T. , Pompilio M. , Romano P. , Salerno G. , Casagli N. , Re G. , Del Carlo P. , Di Roberto A. , Cappello A. , Corradino C. , Amato E. , Torrisi F. , Del Negro C. , Esposito A. M. , De Cesare W. , Caputo T. , Buongiorno M. F. , Musacchio M. , Romaniello V. , Silvestri M. , Marotta E. , Avino R. , Avvisati G. , Belviso P.
Published: August 2022

Open conduit volcanoes like Stromboli can display elusive changes in activity before major eruptive events. Starting on December 2020, Stromboli volcano displayed an increasing eruptive activity, that on 19 May 2021 led to a crater-rim collapse, with pyroclastic density currents (PDCs) that spread along the barren NW flank, entered the sea and ran across it for more than 1 km. This episode was followed by lava flow output from the crater rim lasting a few hours, followed by another phase of lava flow in June 2021. These episodes are potentially very dangerous on island volcanoes since a landslide of hot material that turns into a pyroclastic density current and spreads on the sea surface can threaten mariners and coastal communities, as happened at Stromboli on 3 July and 28 August 2019. In addition, on entering the sea, if their volume is large enough, landslides may trigger tsunamis, as occurred at Stromboli on 30 December 2002. In this paper, we present an integration of multidisciplinary monitoring data, including thermal and visible camera images, ground deformation data gathered from GNSS, tilt, strainmeter and GBInSAR, seismicity, SO2 plume and CO2 ground fluxes and thermal data from the ground and satellite imagery, together with petrological analyses of the erupted products compared with samples from previous similar events. We aim at characterizing the preparatory phase of the volcano that began on December 2020 and led to the May–June 2021 eruptive activity, distinguishing this small intrusion of magma from the much greater 2019 eruptive phase, which was fed by gas-rich magma responsible for the paroxysmal explosive and effusive phases of July–August 2019. These complex eruption scenarios have important implications for hazard assessment and the lessons learned at Stromboli volcano may prove useful for other open conduit active basaltic volcanoes.
Spatial–temporal variations in natural disasters during the Ming and Qing dynasties (1368–1911 AD) in the ancient Huizhou region, eastern China
Authors: Lu Shuguang , Wu Li , Cheng Xianfu , Xu Guanglai , Shen Fei , Li Chenchen , Hu Xiaosi , Yang Baodong , Zhang Hongmei , Li Xiaoxue
Published: August 2022

The Little Ice Age (LIA) during the Ming and Qing dynasties was the most abnormal climate event in China for nearly 2,000 years. During this period, the climate was relatively cold and various natural disasters frequently took place. By locating and compiling related historical documents, we aimed to quantitatively and systematically analyze the spatial–temporal variations in the natural disasters in the ancient Huizhou region (hereinafter referred to as Huizhou region or Huizhou) during the Ming and Qing dynasties (1368–1911; all dates are in AD, unless otherwise mentioned). The results show that (1) flood and drought disasters, the major types of disasters in this area during the Ming and Qing dynasties, occurred 422 times, accounting for 79.6% of the natural disasters, (2) there was a significant correlation of occurrence frequency of flood plus drought disasters and the total natural disasters on a certain time scale. In addition to flood and drought disasters, other disasters (hailstorms, windstorms, frosts, and earthquakes) occurred more frequently in the Qing dynasty (1644–1911) than in the Ming dynasty (1368–1644). The occurrence frequency of natural disasters had a fluctuant variation pattern over time, with peaks emerging about once a century. The peaks of natural disasters were mainly concentrated at 1471–1490, 1571–1590, 1671–1690, 1751–1770, and 1851–1870, which is supported by the wavelet analysis, (3) the most frequent natural disasters took place in Wuyuan, followed by Jixi, Shexian, Xiuning, Qimen, and Yixian. More droughts occurred in Jixi and Yixian, while more floods occurred in Wuyuan, Shexian, and Qimen, more hailstorms occurred in Wuyuan and Jixi, more frost disasters occurred in Wuyuan, Jixi, and Qimen, and more earthquakes occurred in Wuyuan and Jixi. The occurrence frequency of wind disasters was not high in any of the counties, (4) flood and drought disasters in the Huizhou region exhibited obvious stage characteristics during the Ming and Qing dynasties, and they changed gradually from droughts to floods, among which the transition from slight drought to slight flooding was the most obvious during 1811–1911, and (5) overall, slight flooding and slight drought situations accounted for the largest percentage of drought and flood disasters in this area during the Ming and Qing dynasties. Among these, slight flooding mainly occurred in Shexian and Qimen; severe flooding mainly occurred in Wuyuan; slight drought mainly occurred in Yixian; and severe drought mainly occurred in Jixi.
Study on the threshold value of disaster-causing factors of engineering slope cutting in red-layer areas
Authors: Pan Yuangui , Chen Kezhu , Gao Meiben , Wu Zhonggeng , Zheng Guoqiang , He Qingqing , Lu Feng , Wan Yi , Du Chunyang , Cao Nan , Xie Xiaoguo
Published: August 2022

Slope cutting is becoming more common in engineering construction to obtain a large floor area. Slope cutting disrupts a slope’s inherent stability, causing instability and sliding. To solve the problem of geological disasters caused by artificial slope cutting, Cangxi County is used as an example to analyze the cutting slope and the height of different slope structures in the county, to study the disaster mode and disaster factors caused by slope cutting, and to analyze the influence of slope cutting height and slope cutting gradient on the disaster process. This study demonstrates that the stability of cutting on different types of slopes is weakened to different degrees, with mixed rocky-soil slopes having the strongest resistance to weakening, thick-soil slopes the second strongest, and thin-soil slopes the weakest. Slope cutting is the main factor of disaster, and rainwater infiltration promotes landslide formation. Numerical simulation is employed to determine the proximities of the slope cutting height and slope cutting gradient, and 75% of the critical value is taken as the proposed threshold value of slope cutting. The recommended cut slope threshold value corresponds to the real stable cut slope gradient on site, and the research findings can be used to guide engineering cut slope decisions in Cangxi County and other red-layer areas.
Toward learning progression analytics — Developing learning environments for the automated analysis of learning using evidence centered design
Authors: Kubsch Marcus , Czinczel Berrit , Lossjew Jannik , Wyrwich Tobias , Bednorz David , Bernholt Sascha , Fiedler Daniela , Strauß Sebastian , Cress Ulrike , Drachsler Hendrik , Neumann Knut , Rummel Nikol
Published: August 2022

National educational standards stress the importance of science and mathematics learning for today’s students. However, across disciplines, students frequently struggle to meet learning goals about core concepts like energy. Digital learning environments enhanced with artificial intelligence hold the promise to address this issue by providing individualized instruction and support for students at scale. Scaffolding and feedback, for example, are both most effective when tailored to students’ needs. Providing individualized instruction requires continuous assessment of students’ individual knowledge, abilities, and skills in a way that is meaningful for providing tailored support and planning further instruction. While continuously assessing individual students’ science and mathematics learning is challenging, intelligent tutoring systems show that it is feasible in principle. However, the learning environments in intelligent tutoring systems are typically not compatible with the vision of how effective K-12 science and mathematics learning looks like. This leads to the challenge of designing digital learning environments that allow for both – meaningful science and mathematics learning and the reliable and valid assessment of individual students’ learning. Today, digital devices such as tablets, laptops, or digital measurement systems increasingly enter science and mathematics classrooms. In consequence, students’ learning increasingly produces rich product and process data. Learning Analytics techniques can help to automatically analyze this data in order to obtain insights about individual students’ learning, drawing on general theories of learning and relative to established domain specific models of learning, i.e., learning progressions. We call this approach Learning Progression Analytics (LPA). In this manuscript, building of evidence-centered design (ECD), we develop a framework to guide the development of learning environments that provide meaningful learning activities and data for the automated analysis of individual students’ learning – the basis for LPA and scaling individualized instruction with artificial intelligence.
Bile acids, gut microbiota and metabolic surgery
Authors: Tu Jui , Wang Yangmeng , Jin Lihua , Huang Wendong
Published: August 2022

Metabolic surgery, or bariatric surgery, is currently the most effective approach for treating obesity and its complications. Vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the top two types of commonly performed metabolic surgery now. The precise mechanisms of how the surgeries work are still unclear, therefore much research has been conducted in this area. Gut hormones such as GLP-1 and PYY have been studied extensively in the context of metabolic surgery because they both participate in satiety and glucose homeostasis. Bile acids, whose functions cover intestinal lipid absorption and various aspects of metabolic regulation via the action of FXR, TGR5, and other bile acid receptors, have also been actively investigated as potential mediators of metabolic surgery. Additionally, gut microbiota and their metabolites have also been studied because they can affect metabolic health. The current review summarizes and compares the recent scientific progress made on identifying the mechanisms of RYGB and VSG. One of the long-term goals of metabolic/bariatric surgery research is to develop new pharmacotherapeutic options for the treatment of obesity and diabetes. Because obesity is a growing health concern worldwide, there is a dire need in developing novel non-invasive treatment options.
Primary cilium in kidney development, function and disease
Authors: Bai Yunfeng , Wei Cuiting , Li Ping , Sun Xuefeng , Cai Guangyan , Chen Xiangmei , Hong Quan
Published: August 2022

The primary cilium is a hair-like, microtubule-based organelle that is covered by the cell membrane and extends from the surface of most vertebrate cells. It detects and translates extracellular signals to direct various cellular signaling pathways to maintain homeostasis. It is mainly distributed in the proximal and distal tubules and collecting ducts in the kidney. Specific signaling transduction proteins localize to primary cilia. Defects in cilia structure and function lead to a class of diseases termed ciliopathies. The proper functioning of primary cilia is essential to kidney organogenesis and the maintenance of epithelial cell differentiation and proliferation. Persistent cilia dysfunction has a role in the early stages and progression of renal diseases, such as cystogenesis and acute tubular necrosis (ATN). In this review, we focus on the central role of cilia in kidney development and illustrate how defects in cilia are associated with renal disease progression.