bluuebunny/crossref_metadata_2025 huggingface dataset:
Chlorophyll-a Estimation in 149 Tropical Semi-Arid Reservoirs Using Remote Sensing and Machine Learning
Authors: Oliveira Santos Victor , Guimarães Bruna Monallize Duarte Moura , Lima Neto Iran Eduardo , Souza Filho Francisco de Assis , Costa Rocha Paulo Alexandre , Van Griensven Thé Jesse , Gharabaghi Bahram
Published: December 2023

Eutrophication, a global concern, impacts water quality, ecosystems, and human health. It’s crucial to monitor algal blooms in freshwater reservoirs, as they indicate the trophic condition of a waterbody through Chlorophyll-a (Chla) concentration. Traditional monitoring methods, however, are expensive and time-consuming. Addressing this hindrance, we developed models using remotely sensed data from the Sentinel-2 satellite for large-scale coverage, including its bands and spectral indexes, to estimate the Chla concentration on 149 freshwater reservoirs in the state of Ceará, Brazil. Several machine learning models, including k-nearest neighbours, random forests, extreme gradient boosting, the least absolute shrinkage, group method of data handling (GMDH), and support vector machine models were trained and tested. A stepwise approach determined the best subset of input parameters. The best-performing model was the GMDH, achieving an R2 of 0.91 and RMSE of 20.38 mg/L, which is a value consistent with the ones found in the literature. Nevertheless, the predicted Chla concentration values were most sensitive to the red, green, and near infra-red bands.
The Healthy and Diseased Retina Seen through Neuron-Glia Interactions
Authors: Tempone Matheus Heidemann , Borges-Martins Vladimir Pedro , César Felipe Godinho Galvão , Alexandrino-Mattos Dio Pablo , De Figueiredo Camila Saggioro , Raony Icaro , Dos Santos Aline Araujo , Duarte-Silva Aline Teixeira , Dias Mariana Santana , Freitas Hercules Rezende , De Araújo Elizabeth Giestal , Ribeiro-Resende Victor Tulio , Cossenza Marcelo , Petrs-Silva Hilda , Paes-de-Carvalho Roberto , Ventura Ana Lucia Marques , Calaza Karin da Costa , Silveira Mariana Souza , Kubrusly Regina Célia Cussa , De Melo Reis Ricardo Augusto
Published: December 2023

The retina is the sensory tissue responsible for the first stages of visual processing, with a conserved anatomy and functional architecture among vertebrates. To date, retinal eye diseases, such as diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa, glaucoma and others, affect nearly 170 million people worldwide, resulting in vision loss and blindness. To tackle retinal disorders, the embryonic retina has been explored as a versatile model to study development, with a broad neurochemical repertoire, approached in the last decades in terms of signaling and diseases. Retina, dissociated and arranged as typical cultures are valuable to understand both neuronal and glial compartments, as mixed or neuron- and glia-enriched, and/or organized as neurospheres and/or as organoids which have contributed to reveal mechanisms between transmitter systems as well as antioxidants, trophic factors, and extracellular matrix proteins. Overall, contributions in understanding neurogenesis, tissue development, differentiation, connectivity, plasticity, and cell death are widely described. A complete access to the genome of several vertebrates, as well the recent transcriptome at the single cell level at different stages of development also anticipates future advances in providing cues to target blinding diseases or retinal dysfunctions.
Comprehensive Analysis of Management Strategies for Red Palm Weevil in Date Palm Settings, Emphasizing Sensor-Based Infestation Detection
Authors: Mendel Zvi , Voet Hillary , Nazarian Ilan , Dobrinin Svetlana , Ment Dana
Published: December 2023

The red palm weevil (Rhynchophorus ferrugineus) inflicts widespread damage in date palm plantations and urban settings, leading to stand loss and safety concerns, intensified by the economic and ecological burdens of synthetic preventive treatments. A novel approach emphasizes detecting weevil-infested palms through sensors and targeting control efforts at colonized trees. The study analyzes two datasets: field manager-reported results from settings with preventive pest control versus seismic sensor-monitored units. Sensor data translates into damage index values, exploring curative treatments, attack likelihood based on infestation history, and the impact of sensor-based management on infestation incidence decline. Findings reveal lower weevil infestation in urban areas and preventive-treated palm settings. A strong correlation exists between sensor indications and grower decisions in date plantations. Palms previously infested are more prone to the damage. Long-term sensor-based management significantly reduces weevil-affected palm numbers. The high infestation in sensor-equipped date palm settings stems from a gap between sensor-identified and preventively treated palms. Controlling weevils based on sensor indications aligns practically with grower curative treatments, preventing significant damage. Weevils target previously infested palms, optimizing pest control through a continuous strategy integrating sensor monitoring with prompt response treatments. This proves highly effective, offering a cost-efficient alternative to preventive treatment reliance.
The Effect of a Mixed-Enzyme Product in Broiler Diets on Metabolizable Energy, Phosphorus and Calcium Retention
Authors: Walker Harriet , Vartiainen Suvi , Apajalahti Juha , Taylor-Pickard Jules , Nikodinoska Ivana , Moran Colm A.
Published: December 2023

The importance of enzymes in the poultry industry is ever increasing because they help to extract as many nutrients as possible from the raw material available and reduce environmental impacts. Therefore, an experiment was conducted to examine the effect of a natural enzyme complex (ASC) on diets low in AME, Ca and P. Ross 308 broilers (n = 900) were fed one of four diets: (1) positive control (PC) with no enzyme added (AME 12.55 MJ/kg, AVPhos 4.8 g/kg and AVCal 9.6 g/kg); (2) negative control (NC) with no enzyme added and down-specified for AME, Ca and P (AME 12.18 MJ/kg, AVPhos 3.3 g/kg, AVCal 8.1 g/kg); (3) negative control plus ASC at 200 g/t; and (4) negative control plus ASC at 400 g/t. Broiler performance, digesta viscosity, tibia mineralization and mineral content were analyzed at d 21. Between d 18 and 20, excreted DM, GE, total nitrogen, Ca, and P were analyzed. ASC at 200 g/t and 400 g/t improved the FCR (p = 0.0014) significantly when compared with that of the NC. There were no significant differences in BW or FI between the treatments. Birds fed ASC at 200 g/t and 400 g/t had significantly improved digesta viscosity (p < 0.0001) compared with that of the PC and NC and had significantly higher excreted DM digestibility (p < 0.01) than the NC and the PC with 400 g/t ASC. ASC inclusion significantly improved P retention (p < 0.0001) compared with that in the PC. Ca retention was significantly increased by 400 g/t ASC compared with that in the PC and NC (p < 0.001). AME was significantly higher (p < 0.0001) for all treatments compared with that in the NC. There were no significant differences between treatments for any of the bone measurements. This study showed that feeding ASC can support the performance of broilers when fed a specification reduced in Ca, P and AME, with the greatest results being seen with the higher inclusion level of ASC.
Analysis of Combustion Characteristics’ of CI DI VCR Engine using Blends of Mixture of two Biodiesel and Diesel with Artificial Neural Network
Authors: Doddi Suresh , Hosamani B R , Kusur Chidanand s , Puthani Prashant , Mangond Keerti
Published: December 2023

Combustion parameters are the important aspects in the development and research of an internal combustion engines. Hence present work is an attempt to develop an artificial neural network (ANN) model for anticipating the combustion characteristics of computerized CI DI VCR, four strokes, single cylinder, and water cooled engine using mixture of two biodiesel and diesel blends as a fuel. The two biodiesel selected are Jatropha and Simarouba and mixed in the ratio of 75:25. Two biodiesel mixtures is used for the preparation of various blends with diesel. Experiments are carried out at different compression ratio, at different % load and blends B20, B40, B60and neat diesel (B00) fuel to accumulate the assorted combustion data. The input variables are % load, compression ratio, blends and crank angle. The outputs well thought-out are cylinder pressure (CP), net heat release rate (NHRR), cumulative heat release (CHR), rate of pressure rise (RPR), mass fraction burned (MFB) and maximum cylinder pressure. The assessment is focused on developing artificial neural network for the prediction and verifying the combustion characteristics of engine. MATLAB software is used for analysis of different combustion aspects of the engine. Multilayer neural network perceptions are used with Feed-Forward Back Propagation algorithm with performance function for mapping the input and output parameters. The experimental outcomes are compared with ANN estimated results for the analysis. The outcome from the study authenticate that experimental results are in match with ANN results. The accuracy of the ANN model shows the developed model can effectively predict the engine combustion characteristics with excellent regression coefficients ‘R’ and its values are close to unity and the mean square errors are extremely less. ANN model approach is competent towards predicting the combustion aspect of diesel engine with good accuracy
Revolutionizing Medical Education: The Impact of Virtual and Mixed Reality on Training and Skill Acquisition
Authors: D'Urso Fabiana , Piscitelli Prisco , Miani Alessandro , Broccolo Francesco
Published: December 2023

This review explores the integration of Virtual and Mixed Reality in medical training. The advent of immersive technologies has revolutionized traditional methodologies, offering immersive, interactive, and flexible learning environments. This study aims to assess the impact, efficacy, and potential of Extended Reality (XR) in medical education. Methods included a comprehensive analysis of current Metaverse’s applications in various medical fields, including surgery, diagnostics, and patient care. Results indicate a significant enhancement in learning outcomes, practical skills, and student engagement. Conclusions suggest that Virtual Reality is a valuable tool for medical training, providing realistic simulations and improving both theoretical knowledge and practical skills. The intersection of virtual reality and cognitive neuroscience presents an exciting frontier for understanding the human brain's response to immersive environments. This review explores how VR impacts learning, with a particular focus on the activation and engagement of the prefrontal cortex during immersive experiences. It delves into various studies that highlight the transformative potential of VR in educational settings and therapeutic applications, demonstrating how VR can facilitate deeper and more effective learning experiences. The review will present a dedicated section on the current methodologies used to analyze the brain's response while immersed in a virtual environment.
Comparative Cyto-histological Genetic Profile in a Series of Differentiated Thyroid Carcinomas
Authors: Matos Maria de Lurdes , Pinto Mafalda , Alves Marta , Canberk Sule , Gonçalves Ana , Bugalho Maria João , Papoila Ana Luísa , Soares Paula
Published: December 2023

Introduction – Molecular tests can contribute to improve the preoperative diagnosis of thyroid nodules. Tests available are expensive and not adapted to different population. Aim – This study aimed to compare the cyto-histological genetic profile, and to evaluate the reliability of molecular tests on Ultrasound-guided Fine Needle Aspiration Cytology (US-FNAC) in accurately diagnosing differentiated thyroid carcinomas (DTCs) and predicting biologic behavior of papillary thyroid carcinomas (PTCs). Material and methods – The series included 259 patients with paired cyto-histological samples totalizing 518 samples. The genetic alterations were analyzed by PCR/Sanger sequencing. The association with clinicopathologic features was evaluated in PTCs. Results/Discussion – From the 259 patients included, histologies were 50 (19.3%) benign controls and 209 (80.7%) DTCs cases, from which 182 were PTCs; cytologies were 5.8% non-diagnostic, 18.2% benign, 39% indeterminate and 37.1% malignant. In histology, indeterminate nodules (n=101) were 22.8% benign and 77.2% malignant. Mutation frequencies in cytology and histology specimens were, respectively, TERTp: 3.7% vs. 7.9%; BRAF: 19.5% vs. 25.1%; RAS: 11% vs. 17.5%. The overall cyto-histological agreement of the genetic mutations was 94.9%, Cohen’s k=0.67, and in indeterminate nodules 95.7%, k=0.64. The identified mutations exhibited a discriminative ability in diagnosing DTC with a specificity of 100% for TERTp and BRAF, and of 94% for RAS, albeit with low sensitivity. TERTp and BRAF mutations were associated with aggressive clinicopathological features and tumor progression in PTCs (p<0.001). The obtained good cyto-histological agreement suggests that molecular analysis in US-FNAC may anticipate the genetic profile and the behavior of thyroid tumors, confirming malignancy and contributing to refer patients towards surgery.
Digital Inclusion for People with Autism Spectrum Disorders: Review of the Current Legal Models and Doctrinal Concepts
Authors: Hutson J. , Hutson P.
Published: December 2023

Objective: today, a significant part of professional tasks are performed in the digital environment, on digital platforms, in virtual and other meetings. This necessitates a critical reflection of traditional views on the problem of accessible environment and digital accessibility, taking into account the basic universal needs of persons with disabilities.

Methods: a gap between the traditional legal perspective on special working conditions for persons with disabilities and the urgent need of a digital workplace (digital environment) clearly shows lacunas in the understanding of accessibility, which are identified and explored with formal-legal and doctrinal methods. The multifaceted aspects of digital inclusion are revealed based on an informative approach to legislation. It leads, among other things, to searching for recommendations which would fill this gap and contribute to the creation of a more inclusive and responsible legal, social and technological environment.

Results: the research has led to a conclusion that the existing legal, social and technological paradigms need to be re-evaluated. This reevaluation should aim to develop a more inclusive and benevolent concept of accessible environment that takes into account the diversity of human experience and needs, and a wide range of behavioral and cognitive characteristics. Creating special conditions in the workplace for those with overt and covert health problems should become an integral part of the employer's focus, along with improving management efficiency.

Scientific novelty: covert (hidden) health problems have traditionally been understudied, although they include a range of mental and physical impairments, which, like explicit health problems, vary in their origin, intensity, and permanent or episodic character. This study fills a gap in the issues of disability and its legal protection, taking into account the trend of digital inclusion, the dynamic labor activity of today, and the wide range of human abilities and needs.

Practical significance: the aspects of hidden or latent disability considered in the study provide a different perspective at employment, focusing on the workplace conditions that could be created. Employers may be unaware of the need to create special working conditions for those with hidden health problems. This results in negative effects on unemployment, increased sick leave, limited opportunities in the workplace, and more. Employees are often reluctant to disclose their non-obvious health problems to employers; hence, employers should facilitate disclosure of such information by creating relevant conditions. Such an approach will contribute to the legal protection of this category of employees and to further development of the existing legislative regulation, since the latter does not fully comply with today's needs and changed reality.
Ethics of Artificial Intelligence and Robotics: Key Issues and Modern Ways to Solve Them
Authors: Yadav N.
Published: December 2023

Objective: modern achievements in the development and dissemination of digital technologies have attracted the attention of scholars and practitioners to the discussion of key ethical issues related to artificial intelligence and robotics. Hence, this study presents the most relevant of these issues, posing new challenges for legal scholars and practitioners to develop the regulation of artificial intelligence and robotics in terms of technology moralization.

Methods: the research used practice- and risk-oriented approaches, complemented by multidisciplinary analysis of documents (European principles and codes of ethics) and studies, including those devoted to various problems of artificial intelligence and robotics.

Results: the article identifies key ethical issues in the field of artificial intelligence and robotics. It is established that the key ethical issues involved can be solved if they are legally formalized and implemented at the international level. The algorithm proposed by the author, based on the analysis of the digital technologies application, will allow improving the moral actions of technologies in the process of their decision making.

Scientific novelty: the article presents the latest ethical problems that concern scientists and practitioners in the field of artificial intelligence and robotics, and the methods of their solution by ethical and legal means aimed at moralizing technology and increasing its responsibility.

Practical significance: all solutions presented in the article have practical significance and are ready for wide implementation at the international level. Their formalization in normative form and subsequent compliance will reduce the harm that artificial intelligence may cause in applied fields, including robotics using artificial intelligence. Regulatory, including legislative, decisions must therefore be taken as soon as possible to ensure that artificial intelligence and robotics become reliable tools for these systems to be used at work, at home, and in other areas such as shopping centers, stores, schools, universities, etc.
Remote Methods of Conducting Transactions Using Digital Technologies
Authors: Savelyeva T. A.
Published: December 2023

Objective: to substantiate the need to identify new contractual constructs (models) taking into account the specific relations associated with the use of remote method of contract conclusion through digital technologies and to study the possible risks for their participants.

Methods: along with special legal methods, the method of critical analysis was fundamental for the research process, which allowed us to evaluate and interpret the main sources and norms of civil law in relation to distant transactions. It also allowed assessing the current state of legislation in this area in the context of developing processes of digitalization and technologization of civil-law relations.

Results: a critical analysis of the current state of legal regulation of remote ways of concluding contracts is presented, their classification is given. It is concluded that the digital technologies development gives rise to new remote ways of transactions, as well as fills with new content the procedures of contract conclusion, traditional for civil law. The expediency of singling out the concept of a “distant transaction” as a legal category in order to create a special civil-law regime is substantiated, and the basic concept being that of a “distant contract”. Certain types of distant contracts are analyzed to substantiate the need for special legal regimes in cases when the distant method of contract conclusion is combined with the use of digital technologies. It poses such problems as the distribution of risks of technological failures, hacker attacks, compliance with the balance of interests of the parties taking into account information asymmetry, and the need to protect the weaker party.

Scientific novelty: an attempt is made to define such concepts as a “distant contract” and a “distant transaction” and to identify their features. The expediency is substantiated of considering a distant contract as a separate legal construction (model) of the contract. Within this framework, a special legal regime should be developed and fixed, which can be extended to unilateral distant transactions. The problems of legal regulation caused by the use of information technologies are formulated, and legal constructions for their solution are proposed.

Practical significance: the final conclusions and proposals can be used both in contractual practice by the participants of civil turnover and for the normative consolidation of the concept and features of “distant contract”, “distant transaction”. A special legal regime can be created, taking into account the specificity generated by the use of digital technologies.
Wnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma
Authors: Jain Rakesh , Krishnan Shanmugarajan , Lee Somin , Amoozgar Zohreh , Subudhi Sonu , Kumar Ashwin , Posada Jessica , Lindeman Neal , Lei Pinji , Duquette Mark , Roberge Sylvie , Huang Peigen , Andersson Patrik , Datta Meenal , Munn Lance , Fukumura Dai
Published: December 2023

Wnt signaling plays a critical role in the progression and treatment outcome of glioblastoma (GBM). Here, we identified WNT7b as a heretofore unknown mechanism of resistance to immune checkpoint inhibition (αPD1) in GBM patients and murine models. Acquired resistance to αPD1 was found to be associated with the upregulation of Wnt7b and β-catenin protein levels in GBM in patients and in a clinically relevant, stem-rich GBM model. Combining the porcupine inhibitor WNT974 with αPD1 prolonged the survival of GBM-bearing mice. However, this combination had a dichotomous response, with a subset of tumors showing refractoriness. WNT974 and αPD1 expanded a subset of DC3-like dendritic cells (DCs) and decreased the granulocytic myeloid-derived suppressor cells (gMDSCs) in the tumor microenvironment (TME). By contrast, monocytic MDSCs (mMDSCs) increased, while T-cell infiltration remained unchanged, suggesting potential TME-mediated resistance. Our preclinical findings warrant the testing of Wnt7b/β-catenin combined with αPD1 in GBM patients with elevated Wnt7b/β-catenin signaling.
Synthetic Mn3Ce2O5-Cluster Mimicking the Structure and Function of the Oxygen-Evolving Center in Photosynthesis
Authors: Zhang Chunxi , Chen Yang , Su Yao , Han Juanjuan , Chen Changhui , Fan Hong-Jun
Published: December 2023

The photosynthetic oxygen-evolving center (OEC) is a unique Mn4CaO5-cluster that catalyses the water-splitting reaction in nature. It is a long-standing challenge to precisely mimic the structure and function of the OEC in the laboratory. Herein we report two synthetic Mn3Ce2O5-clusters that display unprecedented similarities to the OEC regarding the ten-atom core and the alkyl carboxylate peripheral ligands, as well as the catalytic capability of the water-splitting reaction in aqueous solution. In addition, it has been shown that the oxide bridge in the cluster can rapidly exchange with the isotopic oxygen of H218O in solution. These results, for the first time, demonstrate that cerium can structurally and functionally replace both the calcium and one manganese in the cluster. Our data provide chemical evidence that the oxide bridge could be directly involved in the O-O bond formation in its biological paragon and shed new light on the design of water-splitting catalysts in future.
High Frequency of Alpha7-HPV in Colombian Caribbean Coast Women: Cervical Cancer Screening Analysis
Authors: Aretaga-Pautt Heiser , Leon Sara Cecilia Soto-De , Castano-Caraballo Lorena , Perdomo-Lara Sandra Janeth , Zetien-Arteaga Helvey Ramon , Ricardo-Caldera Dina , Espitia-Pérez Lyda , Avilés-Vergara Paula A. , Tovar-Acero Catalina , Behaine-Bravo Valentina , Bru-Cordero O. Elias
Published: December 2023

Background
Cervical cancer (CC) is a significant global public health concern, particularly in developing countries such as Colombia. The main risk factor involves high-risk HPV types (HR-HPV) infection, coupled with population-specific variables. The Caribbean region in Colombia lacks research on HR-HPV-type frequencies. Therefore, this study aims to establish the prevalence of type-specific HR-HPV and its association with sociodemographic factors among women undergoing cervical cytology screening.
Methods
A cross-sectional study involving voluntary women who provided informed consent and completed a questionnaire capturing sociodemographic, clinical, and sexual behavior information was conducted. All participants underwent cervical cytology and molecular analysis. Generic HPV detection employed three simultaneous PCRs (GP5+/6+, MY09/11, and PU1R/2M), and positive samples were genotyped using the Optiplex HPV Genotyping kit. The analysis encompassed the 12 types of high-risk HPV (HR-HPV-16,-18,-31,-33,-35,-39,-45,-51,-52,-56,-58, and − 59). Frequencies were reported based on geographic subregions within the Córdoba department, and disparities were made between single and multiple infections. Sociodemographic and clinical variables were subjected to multinomial logistic regression, with statistical significance at a p-value < 0.05. The statistical analyses utilized STATA 14® and R-Core Team-software.
Results
We included 450 women, mean age 40 (SD\(\pm\)11.44). PCR analysis revealed 43% HPV-positive (n=192). GP5+/6+ detected the most positives at 26% (n=119), followed by PU1R/2M at 22% (n = 100) and MY09/11 at 15% (n=69). Multiple infections occurred in 87.3% (n=142), primarily 2 to 4 types (47.37%, n=90). Dominant types were HPV-18 (15.6%, n=61), HPV-16 (14.9%, n=58), HPV-31 (13.0%, n = 51), and HPV-45 (11.5%, n=45). Logistic regression identified age above 60 as a risk for concurrent multiple types (OR=6.10; 95% CI 1.18–31.63). Menopause was protective (OR=0.31; 95% CI 0.11–0.89).
Conclusions
Our study reveals a notable prevalence of multiple (2–4) high-risk HPV infections among adult women engaged in CC detection initiatives. Predominantly, α7 species constitute the prevalent HR-viral types, with the Medio Sinú subregion showing elevated prevalence. Menopausal status confers protection against diverse HR-HPV infections. Nevertheless, advancing age, particularly beyond 60 years, is linked to an increased susceptibility to simultaneous infections by multiple HPV-types.
Born with Two Faces: Sequential development of Diffuse Large B-cell Lymphoma and Angioimmunoblastic T-cell Lymphoma with EBV positive and TET2 mutation
Authors: Li Qing , Dai Shishuo , Liu Weiping , Wu Yu
Published: December 2023

There may be significant histopathological and pathogenetic overlap between Epstein–Barr virus (EBV) -positive diffuse large B cell lymphoma (DLBCL) and other lymphomas, including angioimmunoblastic T-cell lymphoma (AITL). Herein, we reported a rare case of an AITL developing two years after the initial diagnosis of EBV-positive DLBCL. Next-generation sequencing (NGS) is used to study genetic mutations in biopsy samples of DLBCL and subsequent AITL. NGS revealed that TET2 mutated in both DLBCL and AITL, while other differential mutations were also detected, reflecting their own characteristics. Since inherent EBV infection plays a role in both AITL and DLBCL, we evaluated the characteristics of lymphoma associated with EBV infection, including morphology and treatment, etc. We deduce that chronic EBV infection and epigenetic TET2 mutations may alter the immune profile or tumor microenvironment of lymphoma cells, resulting in patients presenting with different tumor types at different times. Patients with AITL secondary to DLBCL have a poor prognosis, and the combination of chidamide and chemotherapy is expected to provide new treatment options for these patients, mainly due to the multiplex antitumor mechanism of chidamide in lymphoma.
Strategically dewaxed honeycomb powder is a promising and eco-friendly alternative for the removal of malachite green through fixed bed column
Authors: Kumari Roshni , Khan Md. Adnan , Mahto Mithilesh , Qaiyum Md. Atif , Mohanta Jhilirani , Dey Banashree , Samal Priyanka Priyadarsini , Sambasivaiah B. , Dey Soumen
Published: December 2023

A fixed-bed column study for the removal of malachite green (MG) from the aqueous phase was demonstrated using strategically dewaxed honeycomb powder (HCP). The removal efficiency was tested at several working column parameters such as column bed height, initial dye concentration, working pH, and flow rate. Breakthrough curves have been plotted using throughput volume versus concentration ratio for different parameters to identify the pathway of uptake. Thomas and BDST kinetic models have been exercised to obtain rate constants and uptake capacity. BDST model suggests an adsorption capacity of 196.28 mg/L. The column performance was seen to vary with solution pH and was found favorable at higher pH.The adsorption rate decreases with increasing flow rate but increases with increasing concentration of the dye. Easy regeneration ensures multi-cycle operations. The mechanism of dye adsorption by HCP has been proposed to be a blend of electrostatic attraction and weak forces. Henceforth the use of HCP for removal of MG in column mode may be extrapolated to serve as a promisingagent in the treatment of dye-containing water and wastewater.
Development and validation of a risk prediction model for frailty in patients with chronic diseases
Authors: wang yaling , xu yuanchun , cao wei , he zongsheng , wu nuoyi , cai mingyu , yang li , liu shuying , jia wangping , he haiyan
Published: December 2023

Background
The occurrence rate of frailty is high among patients with chronic diseases. However, the assessment of frailty among these patients is still far from being a routine part of clinical practice. The aim of this study is to develop a validated predictive model for assessing frailty risk in patients with chronic illnesses.
Methods
This study utilized survey data from elderly chronic disease patients (aged ≥ 60 years) at a tertiary hospital in China between 2022 and 2023. A total of 57 indicators were analyzed, encompassing sociodemographic variables, health status, physical measurements, nutritional assessment, physical activity levels, and blood biomarkers. The research cohort was randomly divided into training and validation sets at a ratio of 70–30%. Employing LASSO regression analysis, the study selected the optimal predictive factors based on univariate analysis. Logistic regression models were applied to investigate factors associated with frailty in chronic disease patients. A nomogram was constructed to establish the predictive model. The predictive performance of the model was evaluated using the area under the receiver operating characteristic curve, calibration curves, and decision curve analysis.
Results
This study recruited a total of 543 patients with chronic diseases, among which 237 were included in the development and validation of the predictive model. There were 100 cases (42.2%) presenting frailty symptoms. Multivariate logistic regression analysis revealed that gender, age, chronic diseases, Mini Nutritional Assessment (MNA) score, and Clinical Frailty Scale (CFS) score were predictive factors for frailty in chronic disease patients. Utilizing these factors, a nomogram model demonstrated good consistency and accuracy. The AUC values for the predictive model and validation set were 0.946 and 0.945, respectively. Calibration curves, ROC, and DCA indicated the nomogram had favorable predictive performance.
Conclusions
The comprehensive nomogram developed in this study is a promising and convenient tool for assessing frailty risk in patients with chronic diseases, aiding clinical practitioners in screening high-risk populations.
Registration: ChICTR2300068076 (first recruitment date was 2022/07/06)
Development of a deep learning algorithm to estimate knee adduction moment during gait using a single inertial measurement unit
Authors: Akiba Ayako , Harato Kengo , Yoshihara Hiroshi , Iwama Yu , Nishizawa Kohei , Nagura Takeo , Nakamura Masaya
Published: December 2023

Background: The external knee adduction moment (KAM) during gait is known as a digital biomarker for knee osteoarthritis (KOA). Three-dimensional motion capture system has been used to measure KAM, but it has limitations to measure KAM in cost, measuring time and space.
Purpose: To developed a simple and wearable system to estimate KAM, which can be used in daily practice. For this purpose, a deep learning algorithm was developed to estimate KAM of KOA using data from a single inertial measurement unit on the knee.
Study Design: Cross-Sectional Study. Level 3
Methods: Fifty female and ten male subjects who diagnosed as having KOA were included to develop an AI system. Simultaneous measurements of 5m walk using 3D motion capture and IMU attached on the knee were performed, and a deep learning algorithm was developed base on gait phase detection algorithm and 1D Convolutional Neural Network (CNN) model. Reliability of the AI system was evaluated by 5m gait data of another 13 KOA and 7 asymptomatic subjects.
Results: The mean absolute percent error (MAPE) and the mean absolute error (MAE) of estimated KAM peak of training data set and test data set were 13.0% and 0.0428 Nm.s/(BW*Ht), and 17.3% and 0.0505Nm.s/(BW*Ht) respectively, and those of estimated KAM impulse were 20.4% and 0.0214 Nm.s/(BW*Ht), and 21.4% and 0.0212 Nm.s/(BW*Ht) respectively. Peason’s correlation coefficients between estimated KAM (peak, impulse) and true KAM (peak, impulse) were 0.870 and 0.975 in train data set, and those in the test data set were 0.591 and 0.690. The intraclass correlation coefficients (ICCs) of estimated KAM impulse were 0.83, 0.94, 0.70 and 0.82, for ICCs (1.1), (1,k), (2,1) and (2,k) respectively.
Conclusions:
Using gait phase detection algorithm and 1D-CNN, we have successfully obtained the acceleration parameters (iKAM) from a single IMU data, and the acceleration parameters showed reasonable accuracy and reliability in estimating KAM. We require only single sensor on each knee which needs less calculation and hardware cost. Simple equipment of our system enables us to measure KAM during daily practice at clinic or hospital if there is free space to walk 5m.
Alteration of prefrontal cortex and its associations with emotional and cognitive dysfunctions in adolescent borderline personality disorder
Authors: Xiao Qian , Shen Liying , He Haoling , Wang Xueying , Fu Yan , Ding Jun , Jiang Furong , Zhang Jinfan , Zhang Zhejia , Yi Xiaoping , Chen Bihong T.
Published: December 2023

Background
The neurobiological mechanism of borderline personality disorder (BPD) in adolescents remains unclear. The study aimed to assess the alterations in neural activity within prefrontal cortex in adolescents with BPD and investigate the relationship of prefrontal activity with cognitive function and emotional regulation.
Methods
This study enrolled 50 adolescents aged 12–17 years with BPD and 21 gender and age-matched healthy control (HC) participants. Study assessment for each participant included a brain resting-state functional MRI (rs-fMRI), cognitive testing with Stroop Color-Word Test (SCWT) and clinical assessment questionnaires such as Borderline Personality Features Scale (BPFS), Difficulties in Emotion Regulation Scale (DERS), Ottawa Self-Injury Inventory and Childhood Trauma Questionnaire (CTQ). Fractional amplitude of low-frequency fluctuations (fALFF) and seed-based functional connectivity (FC) were obtained from rs-fMRI analysis. Correlative analysis was also performed to evaluate the associations of the neuroimaging metrics such as fALFF and FC with cognitive testing scores and clinical assessment questionnaire scores.
Results
Adolescents with BPD showed increased fALFF values in the right inferior frontal gyrus and decreased activity in the left middle frontal gyrus as compared to the HC group (p < 0.05, cluster size ≥ 100, FWE correction). In adolescents with BPD, the reduced fALFF in the left middle frontal gyrus was associated with SCWT-A (reading characters) and SCWT-B (reading color). Increased fALFF in the right inferior frontal gyrus was related to BPFS, DERS-F and Ottawa Self-Injury Inventory-4C. Additionally, both the fALFF values in the left middle frontal gyrus and the right inferior frontal gyrus were related to the CTQ-D (emotional neglect) (p < 0.05). The left middle frontal gyrus exhibited increased FC with the right hippocampus, left inferior temporal gyrus and right inferior frontal gyrus (voxel p < 0.001, cluster p < 0.05, FWE correction). The increased FC between the left middle frontal gyrus and the right hippocampus was related to SCWT-C (cognitive flexibility).
Conclusions
We observed diverging changes in intrinsic brain activity in prefrontal cortex, and neural compensatory FC changes to maintain function in adolescents with BPD. In addition, increased neural function as indicated by brain activity and FC was associated with cognitive dysfunction, while decreased neural function was closely associated with emotional dysregulation. These results indicated that alterations of intrinsic brain activity may be one of the underlying neurobiological markers for clinical symptoms in adolescents with BPD.
A case study of furunculosis following an Ayurvedic oil massage and sudation therapy, and lessons to learn
Authors: Kulkarni Satyajit P , Kulkarni Pallavi S , S Kumar
Published: December 2023

India has a long history of using sudation therapy and oil massage as Ayurvedic treatments. However, nothing is known about its side effects, and just two studies have identified side effects as cutaneous Adverse Drug Reactions brought on by Ayurvedic oil massage. We are presenting the example of a 72-year-old adult man who visited our hospital and had his right knee massaged with Nirgudi oil. Erythema, papules, itchiness, and scorching pain were some of his symptoms. However, these sensations only partially abated once we quit massaging. Our investigation demonstrates that the skin reaction associated with furunculosis is brought on by a Nirgudi oil massage or sudation. This case report illustrates the necessity to be aware of Panchakarma-related consequences and suggests that medical practitioners, patients, and product makers take into account the likelihood of such a reaction following Nirgudi oil massage and sudation therapy as a precaution.
Innovative Methodology for Teaching European Studies Using a Corpus Approach
Authors: Anokhina Tetiana , Kobyakova Iryne , Schvachko Svitlana
Published: December 2023

Тhe most popular methodology for teaching European Studies is the methodology is corpus-oriented. The teacher is demonstrating the data and the translation finding information online (Sketch Engine) and in an offline mode (AntConc). It is possible to use many online resources available online avoiding the prepaid data libraries. In addition, we use the Open Library, which contains digitized works of European authors in audio format, access to which is provided by personal free access. In addition, students can provide their digital resources to the shared library. Thus, students may add their digital resources to the shared library. The purpose of this work is to create the shared data resources to learn the European Studies. The open access is viewed as the basic, other data flow is possible and welcomed.
IMAGOLOGICAL PRESENTATIONS IN MODERN POLISH LITERATURE OF THE FACT: THE MIGRANT AS ANOTHER-SUPERDEAL
Authors: Sukhomlynov Oleksiy
Published: December 2023

In recent years, several books have been published in Poland, which deal with the socio-political, cultural and moral situation, as well as aspects of the everyday life of the modern inhabitants of the Republic. An understudied aspect is the multicultural heritage of the Ottoman Empire and the ethno-cultural situation of the modern Turkish Republic. In the article, the author focuses on the analysis of selected works of Witold Szabłowski and Mircelina Szumer-Brysz, where the image of the migrant occupies a special place.
English Phraseological Units as Representatives of National and Cultural Specificity
Authors: Chulanova Halyna , Vnuchkova Viktoriia
Published: December 2023

The article investigates the national and cultural aspect of phraseological units of the English language. This field is underdeveloped, but attracts more and more attention of linguists. This article focuses on highlighting the national and cultural specificity of phraseological units in such areas as cooking, weather, sports, social inequality and history. Each of the above areas is represented by several examples of phraseological units, with an explanation of the meaning and analysis of the cultural component. Understanding the cultural aspect of idioms is important for effective intercultural communication. Each phraseological unit has its own history and influence on modern culture around the world, as English remains the main international language of communication. The article expands the understanding of the relationship between language and culture, emphasizing that culture has a significant impact on both the language of its people and global communication in the world. Each phraseological unit analyzed in the article carries important information about the history, development and formation of the nation as such. Each phraseological unit connects the modern life of the British with their historical past. Therefore, the purpose of the article is to explore and deepen the understanding of the cultural aspect of phraseological units for better communication in international discourse. The study has highlighted the close relationship between language, culture and British national identity.
Review and Opponent’s Review in the System of Scientific and Literary-critical Genres (part 1)
Authors: Ishchenko Olena , Oropaі Anna
Published: December 2023

The article is devoted to understanding the specifics of review and opponent’s review as integral elements of the scientific and literary-critical genre system. It is noted that the increased attention to them in multi-aspect intelligence is explained by the active introduction into the educational process of disciplines aimed at the development of analytical and creative thinking, communication skills, the formation of an aesthetic worldview, etc. The main scientific works were considered, in which an attempt was made to find a comprehensive definition of terms, to create typologies and classifications, and to determine the purpose and tasks of the texts. It is determined that contemporary researchers understand a critical analysis of a scientific source (sources) by review, designed for specialists and created by the author of the same field. The article proves the importance of opponent’s review as work, which contributes to the objective assessment of the results of scientific research. The similarity of structural and content elements of genres is emphasized.
Paternalistic Leadership and Work Engagement in the Innovative Service Industry: The Mediating Role of Psychological Contract
Authors: Aybar Sibel , Cark Ozgur
Published: December 2023

According to the common view, paternalistic leadership, which is accepted in traditional societies, is assumed to be an effective form of leadership and can be persuasive and impose its authority to the extent that it acts in the interests of its followers. It is argued that authority and control behaviours, which we know as paternalistic leadership behaviours, arouse feelings of respect, fear and obedience among followers, and this results in positive organizational behaviours such as loyalty, respect and harmony, especially in Eastern societies. Work engagement is a positive motivational state in which employees have positive feelings toward their work, find their work meaningful, think their professional responsibilities are manageable, and think positively about the future of their work. A psychological contract, on the other hand, is an informal and unwritten, mutually agreed-upon contract that expresses the sum of mutual expectations between an organization and its employees. Whereas there are many studies examining the relationship between paternalistic leadership and work engagement, none of them examine the mediating effect of the relational psychological contract on this relationship, particularly in the innovative service sector. This research was conducted to contribute to filling this gap in the field. This study had two objectives: (1) determining how paternalist leaders influence employee work engagement and (2) identifying whether the relational psychological contract mediates paternalistic leadership and work engagement. Data were collected from 223 gray-collar employees working in the innovative service sector in Turkey through an online survey. The data were analysed using partial least squares (PLS)-structural equation modelling. The results showed that paternalistic leadership significantly affects work engagement and relational psychological contracts. The results also showed that the relational psychological contract fully mediated the relationship between paternalistic leadership and work engagement. Our results are also original in that they show that the relational psychological contract plays a mediating role between paternalistic leadership and work engagement in innovative service industry businesses.
PENGARUH PINJAMAN MODAL USAHA DAN PENDAMPINGAN USAHA TERHADAP PENDAPATAN UMKM
Authors: Prasetyo Candra , Firdaus Muhammad Anang , Karman Abd
Published: December 2023

Abstrak: Modal usaha sangat berpengaruh bagi bertambahnya pendapatan UMKM, diharapkan dengan modal usaha UMKM dapat mengembangkan usahanya dengan mengikuti perkembangan zaman yang ada. Dengan modal usaha juga UMKM bisa berinovasi dengan usahanya sehingga menambah pendapatan. Tidak hanya modal usaha saja, pendampingan kepada para UMKM juga mesti dilakukan demi menangani kasus yang dilalui oleh UMKM sendiri, pendampingan juga berguna untuk membuka pengetahuan baru bagi UMKM yang kurang baik dalam pengelolaannya. Pendekatan penelitian yang dikenakan dalam riset ini merupakan pendekatan riset kuantitatif menggunakan SPSS sebagai alat analisis. Pinjaman modal mempengaruhi secara signifikan peningkatan Pendapatan UMKM. Variabel pendampingan usaha juga mempengaruhi secara signifikan peningkatan Pendapatan UMKM. Variabel independen yakni pinjaman modal serta pendampingan usaha mempengaruhi secara simultan terhadap Pendapatan UMKM.

Kata Kunci: Pinjaman Modal; Pendampingan; Pendapatan; UMKM.

 

Abstract: Business capital has a significant impact on the increase in UMKM income. It is expected that with business capital, UMKM can develop its businesses by following the current trends. With business capital, UMKM can also innovate their businesses to increase income. Not only business capital but mentoring for UMKM must also be carried out to handle cases faced by UMKM themselves, mentoring is also useful to open up new knowledge for UMKM that is not good in management. The research approach used in this research is a quantitative research approach using SPSS as an analysis tool. Loan capital significantly affects the increase in UMKM income. The business mentoring variable also significantly affects the increase in UMKM income. The independent variables, namely loan capital and business mentoring, simultaneously affect UMKM income.

Keywords: Capital loan; Mentoring; Income; MSM.