bluuebunny/crossref_metadata_2025 huggingface dataset:
Research of the range and information support of dietary supplements on the market of Ukraine
Authors: Михалина Г. А. , Городецька І. Я. , Корнієнко О. М. , Грушковська Д. Т.
Published: November 2023

The domestic market of dietary supplements today shows a number of unsolved problems, such as: competition of these products with drugs, their appointment by doctors as the main treatment, distribution by means of network marketing, often by incompetent people without appropriate education. The insufficient level of awareness of doctors and pharmacists and the lack of mechanisms for proper control over compliance with the legislation necessitates the need to update the requirements for the circulation and distribution of dietary supplements.

The aim of the study was to review the range and accompanying information of dietary supplements presented by the Compendium.onLine online resource in the «Dietary Supplements» section.

Methods of information search, content analysis, data systematization and generalization have been used.

It has been established that the classification distribution of dietary supplements on the informational Internet resource Compendium.onLine contains 17 groups that imitate the ATC classification of drugs. The leaders in terms of the items number of dietary supplements are the domestic companies «Keys to Health» LLC – 157 items, and «Beauty and Health» LLC – 136 items. A total of 508 manufacturers are represented in the analyzed population, including 68 manufacturers of drugs, which offered 673 items of dietary supplements, which accounted for 19.92% of their total. Capsules (36.31%) and tablets (23.50%) were most often represented by the form of release. A total of 50 release forms were presented, 78.28% of the analyzed nomenclature was produced in the form of medicinal forms. The analysis of the recommendations content for the use of dietary supplements showed that only in 33.89% of cases the quantitative indicators of the ingredients content are indicated, and in 38.62% – the medicinal properties are declared with medical diagnoses, which may carry risks of a medical nature when they are used, and therefore requires a strengthening of the system of monitoring compliance with existing legal requirements.

It is advisable to introduce special labeling that emphasizes that dietary supplements is not a drug, and a legislative prohibition on doctors prescribing and recommending dietary supplements.
Analysis of the awareness by healthcare professionals and the public about viral hepatitis in the context of decentralisation of diagnostics
Authors: Волкова А. В. , Ноздріна А. А.
Published: November 2023

Viral hepatitis B and C (VH) is a global public health problem. The peculiarity of VH is usually asymptomatic onset of the disease, so early diagnosis and, accordingly, treatment of the disease at early stages will help to reduce mortality and costs associated with treatment of complications.
The aim of our study was to investigate the level of awareness of health care professionals (HCPs) and the general population about VH, as well as their attitudes toward VH testing.
In accordance with the objective, a survey form for healthcare professionals and a survey form for the general population were developed. Methods of comparative, statistical, graphical and logical analysis were used to process the survey results, describe them and draw conclusions.
79% of surveyed healthcare professionals believe that the problem of VH spread is relevant for Ukrainian society, 37% consider VH a very dangerous disease. 63% of respondents know the differences in treatment, but 60% answered incorrectly about the possibility of complete cure of HCV. The main obstacle to diagnosing VH is the belief that people do not belong to the risk group (82.3%), but only 23.3% of the surveyed population will not be diagnosed for this reason. Due to the cost of the procedure, 13.8% of the population will refuse to be tested. 71% of respondents said they knew the main symptoms of VH, while 84% did not consider themselves to be at risk of infection. In case of absence of symptoms, 55% of respondents are not ready to buy a test in a pharmacy for self-diagnosis of VH at their own expense. 89% of respondents are ready to buy a test for self-diagnosis in a pharmacy if they suspect VH. In general, the results of the study emphasize the relevance of decentralization of VH diagnostic services.
The majority of respondents, both among the general population and healthcare professionals, are aware of the ways of VH infection, but do not consider it necessary to be tested. In our opinion, there is an urgent need for an information campaign focused on the need for annual VH diagnosis. In the future, decentralization of testing and information campaigns in cooperation with pharmacists will help reduce the burden on the economic system of providing testing and treatment for people with VH at the expense of the state.
Risk assessment as an important factor in the process of developing the composition of the injection solution
Authors: Шевченко В. О. , Шпичак О. С. , Ролік-Аттіа С. М.
Published: November 2023

At the stages of pharmaceutical development, production and use of a medicinal product, including its components, there is necessarily a certain degree of risk. An effective approach to quality risk management can further guarantee the patient high quality of the medicinal product by establishing preventive measures to identify and control possible quality issues during pharmaceutical development and production.
At the beginning of the pharmaceutical development process, a general risk assessment is performed and it is repeated as information and knowledge deepen, because the medicinal product (MP) must be developed in such a way as to satisfy the needs of patients and perform the intended function. The use of scientific knowledge and risk assessment methodology at the FR stage allows planning the quality of the drug and the production process, which is primarily aimed at protecting the patient himself.
The purpose of the work is to develop the composition (formulation) of the drug based on diclofenac sodium in the form of an injection solution at a concentration of 25 mg/ml, taking into account the justified risks.
The object of the study is MP Diclofenac sodium, a solution for injections, as well as potential risk factors that can affect the quality of the medicinal product at the stage of developing the composition of the drug.
The work uses informative and empirical methods of research by studying, summarizing and comparing documentary data.
On the basis of the CPI analysis, the critical quality indicators (CPI) of the drug Diclofenac sodium, solution for injection, 25 mg/ml were determined.
Taking into account the justified risks, the formulation of the drug based on diclofenac sodium was carried out. The target quality profile is selected, on the basis of which the critical quality indicators of the finished product are determined. Grounded critical quality indicators of the finished product at the formulation stage. An assessment of the risks of the variability of the formulation was carried out, taking into account the properties of the active pharmaceutical ingredient diclofenac sodium, as well as for all auxiliary substances included in the composition of the medicinal product.
Caries preventive efficacy of 2-,3-,4-aminophenylacetic acids hexafluorosilicates
Authors: Гельмбольдт В. О. , Литвинчук І. В. , Хромагіна Л. М.
Published: November 2023

In recent years, ammonium hexafluorosilicates have been actively studied as new potential anti-caries agents, which may compete with traditional fluoride preparations in the future. The pharmacological potential of hexafluorosilicates with substituted phenylammonium cations remains unexplored. The purpose of the work is to study the caries-prophylactic effectiveness of 2-,3-,4-aminophenylacetic acids hexafluorosilicates in the experiment on a model of experimental caries.

2-,3-,4-aminophenylacetic acids hexafluorosilicates (I–III, respectively) were synthesized according to the previously proposed method, reference drugs – NaF and (NH4)2SiF6. The studied drugs were applied to the teeth and gums of rats as part of a gel based on Na-salt of carboxymethylcellulose. The activity of alkaline and acid phosphatases was determined and the mineralization index was calculated in the pulp of incisors. The number and depth of carious lesions of the teeth were calculated and the caries prevention efficiency was calculated. The concentration of calcium ions was determined in the alveolar bone homogenate, the level of malondialdehyde, the activity of elastase, urease, and lysozyme was determined in the mucous membrane of the oral cavity homogenate.

It was established that the caries-prophylactic efficiency of NaF, (NH4)2SiF6, I–III is 38.1%, 33.3%, 28.6%, 59.5%, 64.3%, that is, the anti-caries effect of compounds II and III exceeds the similar indicator of NaF by more than 1,6 and 1,7 times, respectively. The results of determining the phosphatases activity in the pulp of incisors showed that I–III almost completely normalize the mineralizing index. Compounds I–III provide an effective reduction of inflammatory markers, and the maximum effect is achieved when using gels with the participation of compounds II and III. The studied fluoropreparations reduce the activity of urease; the effect of all hexafluorosilicates is more effective compared to the reference drug – NaF. All hexafluorosilicates significantly return lysozyme activity to the control level compared to NaF, with compounds II and III being the most effective. Calculations using the PASS online method demonstrate an increased probability of anti-inflammatory (intestinal), anti-infectious, antiviral (influenza), antiseptic activity in the case of 3-,4-aminophenylacetic acids in the composition of salts II and III, which can lead to potentiation of their joint action and strengthening of anti-caries effect of these compounds. It is planned to continue research on the biological activity of 3-,4-aminophenylacetic acids hexafluorosilicates as potential means of caries treatment and prevention.
Lens disorders in degenerative myopia. Treatment options
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Rabadanova M.G. ,   O.M. Filatov City Clinical Hospital No. 15, Moscow, Russian Federation, Oganezova J.G. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Kremkova E.V. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Yakh'yaeva M.M. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: November 2023

Cataracts are the leading cause of vision loss in patients over 50 years. In addition to senile cataracts, its earlier development due to various risk factors (for example, degenerative myopia characterized by lens opacity even in low myopia) is also an issue. This article discusses the pathogenesis of cataracts with a focus on oxidative stress, which is also important for myopia progression. The published and authors' data on the association between myopia and cataracts are addressed. The importance of early diagnosis of cataract in patients with myopia at the stage of lens suture compaction and its early radial and meridional opacities (that is possible with maximum mydriasis) is emphasized. Potential complex therapy with anti-cataract drops characterized by antioxidant effect is discussed as a pathogenetic approach to delay cataract progression in patients who (for various reasons) are not suitable for surgery. Recommendations for modifying the lifestyle to prevent cataract development are provided. KEYWORDS: degenerative myopia, myopic cataract, lens, oxidative stress, antioxidants, risk factors, drug treatment, pirenoxine. FOR CITATION: Rabadanova M.G., Oganezova J.G., Kremkova E.V., Yakh'yaeva M.M. Lens disorders in degenerative myopia. Treatment options. Russian Journal of Clinical Ophthalmology. 2023;23(4):207–212 (in Russ.). DOI: 10.32364/2311-7729-2023-23-4-6.
Development and progression association of various ophthalmic pathologies with the gut microbiome state (literature review)
Authors:   All-Russian Center for Eye and Plastic Surgery of the Bashkir State Medical University, Ufa, Russian Federation, Rezbaeva G.N. , Babushkin A.E. ,   Ufa Research Institute of Eye Diseases of the Bashkir State Medical University, Ufa, Russian Federation, Orenburkina O.I. ,   All-Russian Center for Eye and Plastic Surgery of the Bashkir State Medical University, Ufa, Russian Federation, Gimranova I.A. ,   Bashkir State Medical University, Ufa, Russian Federation
Published: November 2023

Study results presented in this review concern the role of changes in the intestinal microbiota composition (the so-called gut microbiota dysbiosis) in the development and/or progression of various eye diseases. Nowadays, about 1150 species of microorganisms that can colonize the GIT have been identified, but no more than 20–30% of them can be cultivated. A huge study breakthrough of the gut microbiota species composition in a healthy person, as well as in persons with various pathologies, was obtained after a technique development for DNA sequencing. Modern researches focus on studying the effect of changes in the gut microbiome on human health, including his eyes. This suggests the potential use of this indicator as a non-invasive biomarker during differential diagnosis, as well as its introduction for ophthalmic therapy purposes. In particular, the association between the gut microbiota and the eyes can serve as a basis for the technique development aimed at the treatment of a number of eye diseases. For instance, dry eye syndrome, especially chronic progressive ophthalmic pathology, such as diabetic retinopathy, glaucoma, age-related macular degeneration, etc. KEYWORDS: microbiome, gut microbiota dysbiosis, association with eye diseases, development of treatment techniques. FOR CITATION: Rezbaeva G.N., Babushkin A.E., Orenburkina O.I., Gimranova I.A. Development and progression association of various ophthalmic pathologies with the gut microbiome state (literature review). Russian Journal of Clinical Ophthalmology. 2023;23(4):219–224 (in Russ.). DOI: 10.32364/2311-7729-2023-23-4-8.
Molecular and Microbial Identification of Microbiota of Processed Chicken Products: Mini Review
Authors: Al-maaqar Saleh
Published: November 2023

Chicken and chicken products are a leading source of animal protein classified under poultry meat. They are a healthy and affordable alternative to other protein sources like red meat. This makes poultry meat and eggs a popular dietary component in most countries. Despite the relative safety and nutritional status of fresh chicken meat, it is a perishable product. Its physical and chemical properties make it ideal for microbial spoilage, while its handling from the farm to the fork makes it vulnerable to microbial contamination from multiple sources. The presence and activities of microbial contaminants in chicken meat compromise its quality and safety for human consumption. This review sought to evaluate the conventional microbial methods for identifying the microbiota of processed chicken products as well as the modern, culture-independent methods of microbiota identification. Despite an increased understanding of the presence and activity of microbial communities in processed chicken products, the microbiota that constitutes this community is not well understood, making their presence and activity difficult to control. Also, 16S rRNA sequence and Omic tools were reviewed as some culture-independent techniques for microbiota identification. Thus, the understanding of how bacteria in chicken and chicken products can be controlled and reduced using these methods to improve consumption of chicken and chicken products was systematically explored. The implementation of the outcome of this study would reduce the prevalence of foodborne illnesses in consumers.
Impact of Bank Liquidity and Macroeconomic Determinants on Profitability of Commercial Banks in Bangladesh
Authors: Lalon Raad Mozib , Anika Afroz  , Tasneema Khan
Published: November 2023

This paper aims at investigating the relationship between profitability and liquidity of the State-Owned Commercial Banks of Bangladesh. An important motive of this study is to provide valuable insights into how liquidity influences profitability. There are various research papers on liquidity exposure and the profitability relationship of banks in Bangladesh. But those researches are separately conducted for conventional or Islamic banks or there is a comparative analysis of both banks. But there is little research on the state-owned banking industry. During the Pandemic the banking industry of Bangladesh was affected severely in respect of liquidity risk and it also affected its profitability. There is no recent paper focused on this study. So, this study will try to identify the significant factors that affect the liquidity of a bank and its profitability. In this regard, 10 years’ data from Annual Report of the State-Owned Commercial Banks and macroeconomic data from Bangladesh Bank website and several journals have been collected from 2012-2021. This study primarily aims at exploring the liquidity-profitability relationship using econometric model. Loan to Deposit ratio is used measuring liquidity of a bank. Other control variables Loan Loss Provision to Total Asset (LLPTA) for credit risk, Equity to Total Asset (EQTA) for capital efficiency, Operational expense to Total Asset (OPEXTA) for operational efficiency, Total Asset (TA) for Bank size, Non-performing Loan (NPL) for asset quality, Gross Domestic Product (GDP) for economy size, Inflation (INF) for consumer price index, Interest Rate (INT) for opportunity cost, and the Unemployment rate for measuring labor force. The major finding of this study show that there is a significant positive relationship between liquidity risk and profitability. Among bank-specific variables credit risk, capital efficiency, and bank size have a significant relationship with Profitability which also supports the theory. Macroeconomic variables like interest rate, inflation rate, and GDP have a significant relationship with profitability which also supports the theory. Here BDBL and BASIC should have maintained the liquidity standard mentioned by Bangladesh Bank and BIS to mitigate their liquidity crisis. This study also shows that there is no severe effect of the COVID pandemic on the State-Owned Commercial Banks of Bangladesh. The findings of this study will provide valuable insights for banks and regulators to make informed decisions regarding risk management, liquidity decision, capital allocation, and strategic planning.
A Book and a Heart: Attribution of a Manuscript and a Reliquary of the du Bellay Family
Authors:   Institute of World History of the Russian Academy of Sciences, Kurysheva Marina A.
Published: November 2023

The paper focuses on the attribution of two unique artefacts – a Greek manuscript and a fu-nerary reliquary associated with the du Bellay brothers. The Greek manuscript of the 16th century Grech. 150, stored in the Russian State Library (Moscow), written by the wonder-ful calligrapher Angelos Vergikios, contains the commissioner’s coat of arms in the head-piece. This is the coat of arms of the noble Anjou family du Bellay, which allows us to une-quivocally believe that the manuscript was commissioned by one of the four brothers du Bellay – Guillaume, Jean, Marten, or Rene. The analysis of the brothers’ personal coats of arms with various additional attributes suggests that the manuscript belonged to either Guillaume or Rene. In the first case, the manuscript RGB. Grech. 150 would be datable to 1535–1541, in the second case, to 1535–1536. In 2019, during an archaeological study of La chapelle Notre Dame du Chevet de la cathédrale du Mans, a unique heart-shaped reliquary was found. It can be almost unambiguously attributed to Bishop Le Mans Rene du Bellay, who died in 1546 and bequeathed to place his heart just in this chapel of “musical angels”.
Catholicos Nerses III the Builder: a Historical Portrait
Authors:   Yerevan State University, Hakobyan Zaruhi A. , Kazaryan Ioane A. ,   independent researcher
Published: November 2023

The personality of Catholicos Nerses III the Builder (641–661) is characterized by Armenian chronicles variously. As an active conductor of the Byzantine policy and Orthodoxy in Arme-nia, Nerses tried in all possible ways to strengthen the political and ecclesiastical ties of Ar-menians and Romans, and this resulted in the treaty of 652. Both, Armenians-Monophisites and Armenians-Chalcedonians fought for the welfare and development of the Armenian state. The difference was only in the details of the political vision of the latter during the 7th century. The Armenian-Byzantine alliance became evident already in the 9th century, when Armenia established new relations with Byzantium, as well as in the 10th–11th and 13th centuries, when the Orthodox community and culture reached their heyday in Armenia. Nerses III was the initiator and patron of a number of wonderful church buildings, which largely determined the architectural and artistic image of the epoch. Catholicos Nerses re-built the cathedral in Dvin, erected the churches in Khor Virap, the Holy Zion in Garni, the Holy Sign near the mountain Varaga, as well as the churches in Bagavan and Vagharshakert (Valarshakert). The most outstanding building of Catholicos Nerses is Zvartnots, or the church of the Vigilant Power, which had its replicas in the architecture of Armenia and South Caucasus. Nerses paid much attention to the Christianization of Armenia. All his buildings were some-how connected with this historical event. Moreover, he implemented the program of hieroto-pia – the transferring of the topography of the Holy Land to Armenia: Zvartnots repeated the form of the Holy Sepulcher, the cathedral in Dvin reproduced the composition of the Ba-silica of the Nativity in Bethlehem, the small church in Khor Virap interpreted one of the Palestine Shrines. Nerses III repeated his grandiose idea in his birthplace, in Tayk, erected the churches in Ishkhan, Banak and Oltu (Ukhteats). The historical portrait of Catholicos Nerses III perfectly reflected his era, very bright and unprecedented in the context of the history of medieval Armenia.
Clinical case. Bilateral subtotal mandibulectomy with fusion of the tympanic part of the temporal bone with the medial surface of the angle of the mandible in a puppy
Authors: Spirina A. S. , Spirina O. A. , Kontsevaya S. Yu. , Ermakov A. M.
Published: November 2023

Relevance. A rare, predominantly congenital pathology Fusion of the tympanic part of the temporal bone with the medial surface of the angle of the mandible leads to irreversible pathological processes in the maxillofacial region, which significantly reduces the quality of life of the animal. The article discusses surgical correction options that can improve the dog’s quality of life. A timely procedure increased the comfort of existence and improved the general health of the animal, eliminating discomfort, otitis media and pain.

Methods. The method of choice was technically complex bilateral subtotal mandibulectomy. To perform the procedure, the following were used: surgical dental instruments; dental unit with high-speed and low-speed handpieces; various types of bur. For extra- and intraoral radiography, the following were used: CR7Vet X-ray digitizer with luminoform plates (0, 1, 2, 3, 4, 5); combined general anesthesia with the use of narcotic and potent drugs.

Results. The solution of this problem is possible only operationally, therefore, the method of choice was bilateral subtotal mandibulectomy, the evaluation of which served as the purpose of the study. As a result of the procedure, already on the 14th day, the dog had activity, satisfactory well-being, and no problems with taking food and water. The study of the results of the study showed that the pathology requires immediate intervention, since the outcome of the fusion of the tympanic part of the temporal bone with the medial surface of the angle of the lower jaw in a few weeks can lead to inoperable.
Study of the specific features in the histological structure of the longissimus muscle dorsi in animals of the genus Ovis
Authors: Volkova N. A. , Volkova L. A.
Published: November 2023

Relevance. Interspecific hybridization of domestic animals with wild related species is considered as one of the promising directions in animal husbandry in the framework of improving the quality and nutrient biodiversity of livestock products. The article shows the research results of the specific features in the histological structure of the longissimus muscle dorsi in animals of the genus Ovis with different genotypes.

Methods. The object of research was sheep of the Romanov breed and interspecific hybrids of domestic sheep (Romanov breed) with argali. Histological studies of the longissimus dorsi muscle of purebred and hybrid animals at the age of 12 months were carried out in a comparative aspect. The thickness and area of muscle fibers, muscle bundles, the number of muscle fibers per unit cross-sectional areas were studied.

Results. Differences in a number of morphometric parameters in the main structural units of the longissimus dorsi muscle in hybrid animals depending on the genotype were revealed. In hybrid animals, in comparison with purebred sheep, a decrease in the thickness and area of muscle fibers by 12% and 25% was found (p < 0.01). An increase in the number of muscle fibers per 1 mm2 of the cut and a decrease in the proportion of connective tissue in the structure of the longissimus dorsi muscle in interspecific hybrids were shown in comparison with those in sheep of the Romanov breed (p < 0.01). These biological features of hybrid animals should be taken into account when breeding, selecting and using them to obtain meat and meat products.
Influence of a biotechnological additive on the weight growth of broiler chickens
Authors: Neverova O. P. , Gorelik O. V. , Kharlap S. Yu. , Rebezov M. B. , Zinina O. V. , Chepushtanova O. V. , Alexandrina E. V. , Neverova E. P.
Published: November 2023

Relevance. The aim of the work is to study the effect of the biotechnological additive (dietary supplement) «Ares» in the cultivation of broiler chickens on their weight growth.

Methodology. Scientific and production experience was carried out in the conditions of the poultry workshop of the educational and experimental farm of the Ural State Agrarian University on the poultry of the «Coob 500» cross. In all experiments, the control group›s poultry received a general household ration, the 1st experimental was given «Ares» additive in water in the amount of 150 g/t, the 2nd experimental was given «Ares» additive in feed in the amount of 300 g/t.

Results. As a result of the research, it was found that all chickens (regardless of the group) increased their live weight with age, reaching 2632–2880 g by the end of cultivation, which meets the requirements of the cross standard. The highest live weight was obtained in the 2nd experimental group, where dietary supplements «Ares» were used in dry form in the amount of 300 g per 1 ton of compound feed. Absolute growth increases with age, which is most likely due to the increase in linear and volumetric sizes of chickens and their ability to increase feed intake. Over the entire growing period, their live weight increased 68.7, 67.2 and 73.8 times. The best indicators were in the group of chickens that additionally received 300 g/t of «Ares» dietary supplement feed. Starting from the 7th day, they had an excess of absolute growth indicators over chickens from other groups. The use of an additive in the form of a solution with a dose of 150 g per 1 ton of water showed a decrease in absolute growth over the entire growing period. The peculiarities of weight growth in broiler chickens receiving dietary supplements «Ares» were established, and the growth of broiler chickens itself followed the general biological patterns of growth and development.
Proses Pembuatan Shell pada Bejana Tekan di PT. XYZ Cikarang
Authors: Nugroho Farhan Adi , Oleh Oleh
Published: November 2023

Bejana tekan dirancang khusus untuk menahan tekanan dari fluida di dalamnya yang mungkin memiliki tekanan berbeda dengan tekanan lingkungan sekitarnya. Ini mencakup berbagai jenis wadah tertutup, seperti tangki penyimpanan, tangki reaktor, dan pipa bertekanan. Tekanan operasi bejana tekan dapat berasal dari tekanan internal (tekanan dari fluida di dalam bejana), tekanan eksternal (tekanan dari lingkungan sekitarnya), atau kombinasi dari keduanya. Tujuan di adakan penelitian ini adalah untuk mengetahui ketebalan shell menggunakan material SA 240 304L dan mengetahui tekanan maksimum yang diberikan ketika produk sedang dalam bekerja (MAWP). Metode yang dipakai dalam penelitian ini adalah metode elemen hingga untuk menganalisa pengaruh terhadap tegangan maksimum yang diterima pada bejana tekan. Hasil analisis adalah bejana tekan yang paling efektif adalah ketebalan minimum sebesar 1,54 mm dan tekanan kerja maksimal yang diijinkan (MAWP) pada shell bejana tekan tersebut sebesar 19,35 kg/cm^2 (18,975 Bar).
ІННОВАЦІЙНІ ТЕХНОЛОГІЇ ШТУЧНОГО ІНТЕЛЕКТУ В УПРАВЛІННІ ЛОГІСТИКОЮ СОЦІАЛЬНИХ ПІДПРИЄМСТВ
Authors: Медведєв Євген , Попова Юлія , Коваленко Микола
Published: November 2023

У статті розглянуто специфіку застосування інноваційних технологій штучного інтелекту в сучасних бізнес-процесах. Визначено особливості використання штучного інтелекту в діяльності соціальних підприємств, які мають своєю метою не тільки забезпечення прибутку, але й розв’язання актуальних соціальних та екологічних проблем суспільства. Доведено, що логістика відіграє важливу роль у функціонуванні соціальних підприємств, оскільки ефективне управління логістичними процесами дозволяє досягти сталості та оптимізації їх діяльності. Досліджено вплив інноваційних технологій штучного інтелекту на управління логістикою в контексті соціальних підприємств. Розглянуто різноманітні аспекти використання штучного інтелекту в логістиці, включаючи автоматизацію виробничих процесів, прогнозування попиту, оптимізацію маршрутів та планування виробничих запасів. Визначено переваги, які можуть виникнути внаслідок впровадження інноваційних технологій, зокрема такі як зменшення витрат, підвищення ефективності діяльності підприємства та покращення рівня обслуговування клієнтів.
ПСИХОЛОГО-ПЕДАГОГІЧНА КЛАСИФІКАЦІЯ МОВЛЕННЄВИХ ПОРУШЕНЬ ДІТЕЙ ДОШКІЛЬНОГО ТА МОЛОДШОГО ШКІЛЬНОГО ВІКУ
Authors: ЛУК’ЯНИК Людмила
Published: November 2023

У статті розглянуто психолого-педагогічну класифікацію мовленнєвих порушень дітей дошкільного та молодшого шкільного віку, адже за статистикою кількість дітей із порушеннями мовлення з кожним роком зростає. Саме у дошкільному та молодшому шкільному віці створюється підґрунтя для успішного розвитку мовлення, а сприяє цьому корекційно-педагогічна робота педагогів, що й обумовлює актуальність даного дослідження. Метою статті є теоретичний аналіз психолого-педагогічної класифікації мовленнєвих порушень дітей дошкільного та молодшого шкільного віку. Наукова новизна: достовірність психолого-педагогічної класифікації мовленнєвих порушень дітей дошкільного та молодшого шкільного віку під час корекційно-педагогічної роботи педагога можлива за умови точної діагностики мовленнєвих недоліків у дітей дошкільного та молодшого шкільного віку, вчасно проведеної корекційно-педагогічної роботи щодо пропедевтики мовленнєвих порушень, формування й удосконалення мовленнєвих умінь дітей дошкільного та молодшого шкільного віку. Тема багатогранності проблеми діагностики та корекції мовленнєвих порушень у дітей дошкільного та молодшого шкільного віку розкривається у фундаментальних класичних і сучасних наукових дослідженнях. Запропоновано різні класифікації з корекційно-педагогічного досвіду багатьох дослідників: психологів, логопедів, лінгводидактів. Було визначено сутність понять: «фонетичні порушення мовлення», «фонетико-фонематичні порушення мовлення», «лексико-граматичне недорозвинення мовлення», «загальне недорозвинення мовлення». Враховано психолого-педагогічну та клініко-педагогічну класифікації мовленнєвих порушень дітей дошкільного та молодшого шкільного віку. Доведено, що поряд із порушеннями вербального характеру, дітям властиві певні особливості вищих психічних функцій: нестійкість довільної уваги, труднощі перемикання, стійкості пам’яті (особливо на мовний матеріал), труднощі в розумінні абстрактних понять, і т. д. Все це перешкоджає успішній навчальній діяльності та обумовлює нестійку успішність дітей. Отже, в учнів початкових класів з нормотиповим розвитком мовлення має бути сформоване на лексичному, граматичному, і фонематичному рівнях. Тому невід’ємним елементом освітнього процесу на даному етапі розвитку суспільства є корекційно-педагогічна робота педагогів над мовленнєвими недоліками учнів.
Analisis Jaringan Komputer LAN (Local Area Network) Pada Dinas XXXXXX
Authors: I kadek Noppi adi jaya , Adi Wardana I Putu Mahendra
Published: November 2023

Perkembangan teknologi informasi membuat revolusi besar dalam dunia industri. Berkembangnya teknologi informasi sangat cepat berpengaruh juga pada jaringan komputer dimana sistem yang berjalan akan memerlukan sebuah akses satu sama lain. Tujuan dilakukannya penelitian ini adalah untuk melakukan analisa terhadap sistem jaringan local area network (LAN) yang berguna untuk memaksimalkan fungsi kerja yang sudah ada pada beberapa Komputer PC yang tersedia. Hasil yang didapatkan dari analisa jaringan local area network adalah klien yang terhubung ke LAN berkisar 150-200 unit, terdapat 6 (enam) unit server antara lain (Server Documentum dan Proxy, Server DC, Server Email, Server FTV, Server AV & BU). Selain itu juga mendapatkan terdapat juga perangkat tambahan seperti Switch 24unit, Router, dan menggunakan kabel Unshielded Twisted Pair (UTP) CAT 5 dan CAT 6.
Sistem Informasi Pembayaran SPP Berbasis Website Pada SMK Muhammadiyah 3 Tegaldlimo
Authors: Putra Diva Ananda , Kurniawan Gede Aby Sanjiwa , Wulandari Ni Nyoman Sekarini , Nababan Elma Regina , Sukerni Komang , Wicaksana Gusti Ngurah Yogi , Mahendra Gede Surya
Published: November 2023

Seiring dengan perkembangan zaman, teknologi dan era globalisasi, manusia dituntut untuk bekerja secara lebih profesional, maka diperlukan sebuah hal guna membawa perbaikan di segala bidang. Banyak instansi atau organisasi publik yang menggunakan komputer untuk mendukung kegiatan operasional mereka, salah satunya adalah SMK Muhammadiyah 3 Tegaldlimo. Tujuan dari adanya penelitian ini adalah untuk merancang serta membuat sistem informasi pembayaran SPP pada SMK Muhammadiyah 3 Tegaldlimo berbasis web dan Selain itu juga dapat menghasilkan suatu sistem yang memudahkan pihak sekolah, baik dari pegawai maupun siswa. Penelitian ini menempati peran yang penting dalam kegiatan pembayaran di SMK Muhammadiyah 3 Tegaldlimo. Dalam melakukan aktivitas ini, pembayaran uang sekolah masih tergolong manual, yaitu menggunakan dokumen buku. Teknologi informasi tidak hanya mempengaruhi sistem tetapi juga mempengaruhi kehidupan sehari-hari, sehingga dibutuhkan program komputer untuk memulihkan sistem informasi cepat pada pembayaran SPP. Rumusan masalah dari penelitian ini adalah “Perancangan sistem informasi pembayaran SPP Berbasis Website pada SMK Muhammadiyah 3 Tegaldlimo”. Pada penelitian ini, peneliti menggunakan beberapa metode, antara lain Observasi, Analisis, Desain, Implementasi dan Uji Coba. Merancang dan Membangun Sistem Informasi Pembayaran SPP Berbasis Website Website ini menggunakan bahasa pemrograman atau script yang meliputi PHP dan MySQL.
PENERAPAN GEOGRAPHICALLY WEIGHTED REGRESSION PADA KASUS PNEUMONIA BALITA DI KABUPATEN ACEH TAMIANG, KOTA LANGSA, DAN KABUPATEN ACEH TIMUR
Authors: Ray Milenia  , Riezky Purnama Sari  , Fitra Muliani
Published: November 2023

Pneumonia merupakan pembunuh utama balita di dunia. Pneumonia adalah bentuk parah dari infeksi saluran pernafasan akut bagian bawah yang secara khusus mempengaruhi paru dengan keadaan alveoli pada salah satu atau kedua paru-paru terisi oleh cairan yang menyebabkan terganggunya oksigen sehingga membuat sulit bernapas. Gejala yang dialami balita penderita pneumonia yaitu sesak nafas atau nafas cepat disertai flu dan batuk. Pada penelitian ini terdapat variabel bebas yaitu balita usia kurang dari 1 tahun (X 1 ), balita jenis kelamin laki-laki (X 2 ), balita dengan gizi sedang (x 3 ), balita tidak diberi vitamin A (X 4) dan variabel terikat yaitu jumlah balita penderita pneumonia. Metode yang digunakan pada penelitian ini yaitu Geographically Weighted Regression (GWR). Sumber data yang digunakan pada penelitian ini yaitu data kasus pneumonia balita tahun 2020 dari Dinas Kesehatan Kabupaten Aceh Tamiang, Dinas Kesehatan Kota Langsa dan Dinas Kesehatan Kabupaten Aceh Timur. Tujuan dari penelitian ini yaitu untuk mengetahui hasil penerapan model GWR pada kasus pneumonia balita serta untuk mengetahui faktor-faktor yang berpengaruh secara signifikan terhadap jumlah kasus pneumonia balita di Kabupaten Aceh Tamiang, Kota Langsa, dan Kabupaten Aceh Timur. Hasil analisis data menunjukkan bahwa model GWR merupakan model terbaik untuk memodelkan kasus pneumonia balita dibandingkan regresi linier berganda dengan nilai R2 GWR yaitu 0.993362 dan nilai AIC GWR yaitu 69.074801. faktor-faktor yang berpengaruh signifikan terhadap jumlah balita Faktor penderita pneumonia yaitu faktor balita berjenis kelamin laki-laki (X 2 ) dan balita yang tidak diberi Vitamin A (X 4 ).
Dalgaları Arasında Şiir Taşıyan Taş: Divan Şiirinde Mermer
Authors: AYDIN Fatıma
Published: November 2023

Osmanlı dönemi mimarisinde mermer önemli bir yer tutmaktadır. Divan şairleri çevrelerinde gözlemledikleri mermer kullanımlarını şiirlerine taşımışlardır. Klasik şairler bu taşı tanımlamak için mermer kelimesinin yanında “hârâ” ve “rûhâm” kelimelerini de kullanmışlardır. Divan şiirine baktığımızda mermerin minber, türbe, ev, hamam, saray, mezar taşı, kitabe veya havuz gibi çok farklı alanlarda kullanıldığını görmekteyiz. Divan şairleri güzelliği ve sağlamlığı ile şiiri, beyazlığı ile sevgilinin tenini ve ellerini, sertliği ile sevgilinin kalbini, rakibin acımasızlığını mermere benzetmişlerdir. Mermer ile diğer değerli taşlar arasında benzerlik ve farklılıklar Divan şairinin dikkatini çekmiştir. Elmas veya safir gibi mermer de maden ocaklarından çıkarılır fakat onlar kadar değerli değildir. Şiirlerde mermer ile su arasında mevc (dalga) sahibi olmaları açısından benzerlik kurulurken sertlik açısından zıtlık vurgulanmıştır. Mermerin benzetildiği bir diğer mefhum ipektir. Hârâ kelimesi hem ipek hem de mermer anlamına uygun düşecek şekilde şiirlerde kullanılmıştır. Doğada mermerin birçok farklı rengi bulunmaktadır. Divan şairleri siyah, mavi ve özellikle beyaz renkli mermerlerden bahsetmişlerdir. Övülen kişinin cömertliği, mermerde çiçek/çimen bitiren bir yağmur olarak tasvir edilmiştir. Mermer her ne kadar sertliği ile anılsa da şairler âşığın bedduasının mermeri dahi delebileceğinini inanmaktadır. Divan şairleri mermer kelimesini “mermere sikke kazımak”, mermere nükte kazımak” ve “zâd-ı sahtı mermerden almak” gibi deyimler içerisinde de kullanmışlardır
AVANCES EN EL NUEVO SISTEMA PARA DISEMINAR EL UTC(CNMP) POR VOZ EN PANAMÁ
Authors: Ovalle Johan , Solís Raúl
Published: November 2023

El objetivo de este proyecto es el desarrollo de un nuevo Sistema de Diseminación del UTC(CNMP) por voz mediante llamadas telefónicas para el Laboratorio de Diseminación de Tiempo y Frecuencia del CENAMEP AIP. Este sistema funciona mediante grabaciones de voz que son reproducidas directamente por el sistema a la línea telefónica de la que recibe la llamada. La diseminación de la hora se realizará de manera gratuita, buscando beneficiar a toda la población de Panamá, incluyendo individuos, empresas, oficinas del gobierno, o cualquier otra organización que desee darle uso. Además, cumplirá con la función de servir como referencia de tiempo oficial para sistemas que no requieran el nivel de precisión que puede tener acceso a un sistema NTP (Network Time Protocol) seguro. Este proyecto se desarrolló mediante financiamiento por la SENACYT para Estancias Académicas para estudiantes universitarios del año 2022.
ESTIMACIÓN REMOTA DE CAUDAL EN UN RÍO UTILIZANDO METODOLOGÍA PIV CASO DE ESTUDIO RÍO LA VILLA
Authors: Concepción Erick , Hooper Mauricio
Published: November 2023

En la actualidad la estimación remota de parámetros o variables ha brindado a la sociedad científica la posibilidad de contar con una fuente de información para abastecer la escases de datos que puede existir a causa de factores como el acceso a un lugar de estudio específico o la dificultad de medición de un parámetro o variable. Las estimaciones remotas de mayor impacto e innovación dentro de la hidrología es la estimación del caudal de un río. En esta investigación se propone la utilización de una metodología innovadora que calcula el caudal de un río a partir de fotogramas extraídos de grabaciones de videos. La metodología fue puesta en práctica en el Río La Villa donde se estimaron caudales en el rango de 6 m3/s y 18 m3/s. Se estimó un caudal promedio para el primer transecto de 9.14 m3/s y un caudal promedio para el segundo transecto de 10.96 m3/s. La metodología propuesta funciona como una herramienta para la estimación de caudales de río donde no existan equipos de registro de caudal, las profundidades del cauce sean demasiado profundas para llevar a cabo las técnicas tradicionales de medición o donde los ríos representen un riesgo para un usuario por un alto caudal.
As implicações da pandemia Covid-19: Repercussões sobre as atividades acadêmico-científicas de docentes de pós-graduação stricto senso em Engenharia de Produção da região sudeste do Brasil
Authors: Maluf Euclides Brandão , Corrêa Dalila Alves
Published: November 2023

The Covid-19 pandemic has brought a series of challenges and transformations to various sectors of society, including higher education. This article presents part of the results of a study that investigated the implications of this phenomenon on the work of a group of faculty members assigned to stricto sensu graduate programs in Industrial Engineering in the Southeast region. These programs play a direct role in training highly specialized professionals, either for the field of scientific research and/or the business environment. On a national scale, the Southeast region significantly accounts for 57% of these programs. By analyzing the changes, adaptations, challenges, learning experiences, and gains in the context of the pandemic, the study sheds light on the various facets of the manifestation of this event, covering topics and situations typical of the work of faculty members operating at this educational level. The article highlights the repercussions on the teaching, research, and outreach activities of the faculty by identifying the need for adaptations and revisions, as well as implications related to the development of remote work. The study was conducted with the support of a literature review and a qualitative field survey. It involved 55 faculty members from 11 programs in the mentioned region. Data collection took place online under the supervision of one of the article's authors and was carried out in May 2023. The study is linked to research investigating the impact of the Covid-19 pandemic on the work of faculty members, specifically in the field of Industrial Engineering in stricto sensu postgraduate programs.
Electroacupuncture Stimulation Alleviates Inflammatory Pain in Male Rats by Suppressing Oxidative Stress
Authors: ZHANG R , ZHU B , ZHAO J , ZHAO L , WANG L
Published: November 2023

In the present study, we focused on whether the analgesic effect of Electroacupuncture (EA) is related to the regulation of oxidative stress. We established a chronic inflammatory pain model in male rats by a single injection of complete Freund’s adjuvant (CFA) and then treated the animals with daily EA stimulation at the site of “zusanli”. The analgesic effect of EA was evaluated by measuring the paw withdrawal threshold (PWT) when rats received mechanical and thermal pain stimulation. The levels of inflammation-related molecules and oxidative stress-related markers in the spinal cord were measured by western blotting or ELISA kits. EA stimulation and antioxidants effectively increased the PWT in CFA rats. Co-treatment of CFA rats with the ROS donor t-butyl hydroperoxide (t-BOOH) further decreased the PWT and weakened the analgesic effect of EA. EA treatment inhibited inflammation and oxidative stress, as shown by decreased levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and MDA and increased activity of SOD and catalase. Moreover, EA reduced the expression of p-p38, p-ERK, and p-p65 and simultaneously downregulated the expression of TRPV1 and TRPV4 in CFA rats. In an in vitro study, direct stimulation with t-BOOH to the C6 cells increased the production of TNF-α, IL-1β, IL-6, activated p38, ERK, and p65 and up-regulated the expression of TRPV1 and TRPV4, and these effects could be prevented by the ROS scavenger PBN. Taken together, our data indicate that the inhibition of oxidative stress and the generation of ROS contribute to the analgesic effect of EA in male CFA rats.
Role of LncMALAT1-miR-141-3p/200a-3p-NRXN1 Axis in the Impairment of Learning and Memory Capacity in ADHD
Authors: MU Y , LI J , ZHANG S , ZHONG F , ZHANG X , SONG J , YUAN H , TIAN T , HU Y
Published: November 2023

As a prevalent neurodevelopmental disease, attention-deficit hyperactivity disorder (ADHD) impairs the learning and memory capacity, and so far, there has been no available treatment option for long-term efficacy. Alterations in gene regulation and synapse-related proteins influence learning and memory capacity; nevertheless, the regulatory mechanism of synapse-related protein synthesis is still unclear in ADHD. LncRNAs have been found participating in regulating genes in multiple disorders. For instance, lncRNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) has an essential regulatory function in numerous psychiatric diseases. However, how MALAT1 influences synapse-related protein synthesis in ADHD remains largely unknown. Here, our study found that MALAT1 decreased in the hippocampus tissue of spontaneously hypertensive rats (SHRs) compared to the standard controls, Wistar Kyoto (WKY) rats. Subsequent experiments revealed that MALAT1 enhanced the expression of neurexin 1 (NRXN1), which promoted the synapse-related genes (SYN1, PSD95, and GAP43) expression. Then, the bioinformatic analyses predicted that miR-141-3p and miR-200a-3p, microRNAs belonging to miR-200 family and sharing same seed sequence, could interact with MALAT1 and NRXN1 mRNA, which were further confirmed by luciferase report assays. Finally, rescue experiments indicated that MALAT1 influenced the expression of NRXN1 by sponging miR-141-3p/200a-3p. All data verified our hypothesis that MALAT1 regulated synapse-related proteins (SYN1, PSD95, and GAP43) through the MALAT1-miR-141-3p/200a-3p-NRXN1 axis in ADHD. Our research underscored a novel role of MALAT1 in the pathogenesis of impaired learning and memory capacity in ADHD and may shed more light on developing diagnostic biomarkers and more effective therapeutic interventions for individuals with ADHD.