bluuebunny/crossref_metadata_2025 huggingface dataset:
Employment status changes of workers after referral to an occupational disease clinic
Authors: Beyan Ayse Coskun , Demiral Yucel , Cimrin Arif
Published: October 2018

Objective

Occupational diseases (OD) are among the most significant issues of work life, with economic, medical, social, and ethical aspects. The majority of studies concerning OD focus on the causes or medical outcomes of OD. There are a limited number of studies investigating the social and economic impacts of being diagnosed with an OD. One of the important social aspects of OD is the employability of workers after an OD diagnosis. The aim of this study is to evaluate the changes in employment status after the OD diagnosis process.

Methods

This is a cross sectional study. There were 204 eligible cases, and 198 (97%) completed the study. The study data were obtained from patient files, including OD Committee reports and questionnaires applied via telephone interview.

Results

Among the 198 applicants, 170 (85.9%) were male and 146 (73.7%) were diagnosed with an OD. Of these workers, 106 (53.5%) had quit their current jobs. Of those workers, 89 out of 106 were in the OD group, and 17 were in the non- OD group. Diagnosis with OD (OR: 3.1 CI: 1.4-6.8) and non-union membership (OR : 11.1 CI : 5.2-23.5) increased the likelihood of quitting the job after an OD diagnosis.

Conclusion

The short-term prognosis of OD was relatively poor. OD diagnosis or even referral to an outpatient clinic may cause quitting the job. Policies should account for the risk of unemployment after an OD diagnosis, and OD surveillance systems should obtain data on the employment status of workers following diagnosis.
Involucramiento Parental Basado en el Hogar y Desempeño Académico en la Adolescencia
Authors: Morales-Castillo Miguel , Aguirre-Dávila Eduardo
Published: October 2018

El artículo analiza el involucramiento parental basado en el hogar como práctica de crianza asociada al desempeño académico de los adolescentes. A través de la revisión sistemática de estudios con resultados empíricos en seis bases de datos, se presenta la influencia multidimensional del involucramiento parental en el hogar —expresado como monitoreo, apoyo, comunicación, instrucción, socialización académica y disposición de recursos—. Los hallazgos reportados sugieren el lugar relevante de las creencias parentales, el apoyo y la comunicación, para comprender el efecto del involucramiento parental en las trayectorias de desempeño académico durante la adolescencia. De igual forma, se manifiesta la importancia de interpretar dichos efectos con la mediación de diferentes factores personales de los adolescentes.
Galois theory for comatrix group corings
Authors: Chen Quan-Guo , Pang Yang-Lei , Wang Ding-Guo
Published: October 2018

In this paper, we introduce comatrix group corings and define the generalized Galois group corings. Then we give the generalized Galois group coring Structure Theorem.
Efficient online packing of 4-dimensional cubes into the unit cube
Authors: Januszewski Janusz , Zielonka Łukasz
Published: October 2018

Any sequence of 4-dimensional cubes of total volume not greater than 1/8 can be online packed into the unit cube.
On the Skitovich-Darmois-Ramachandran-Ibragimov theorem for linear forms of Q-independent random sequences
Authors: Rao B. L. S. Prakasa
Published: October 2018

We characterize the normal distribution based on the Q-independence of linear forms based on infinite sequences of Q-independent random variables.
A note on reverses of the young type inequalities via Kantorovich constant
Authors: Nasiri Leila , Shkalikov Andrei A. , Shakoori Mahmood
Published: October 2018

In present paper, we give some new reverses of the Young type inequalities which were established by X. Hu and J. Xue [7] via Kantorovich constant. Then we apply these inequalities to establish corresponding inequalities for the Hilbert-Schmidt norm and the trace norm.
Power and hölder type trace inequalities for positive operators in Hilbert spaces
Authors: Dragomir Silvestru Sever
Published: October 2018

In this paper we obtain some new power and hölder type trace inequalities for positive operators in Hilbert spaces. As tools, we use some recent reverses and refinements of Young inequality obtained by several authors.
The Results of a Three-Year Pneumococcal Vaccination of Children in Russia
Authors: Briko Nikolay I. , Korshunov Vladimir A. , Namazova-Baranova Leyla S. , Lobzin Juriy V. , Baranov Alexander A. , Kostenko Natalia A. , Fedoseenko Marina V. , Kajtukova Elena V. , Vishneva Elena V. , Tkachenko Natalia E. , Kaljuzhnaya Tatiana A. , Shakhtakhtinskaya Firuza Ch. , Broeva Marika I. , Semikina Elena L. , Mayanskiy Nikolay A.
Published: October 2018

Background.After inclusion of pneumococcal vaccination in the National Vaccination Schedule, it is very important to evaluate the efficacy of routine immunisation of the child population for more than 3 years. The obtained results provide opportunity to analyse the problems in achieving the goal, determine their causes, and suggest the ways of overcoming. Our aim was to study the results of a three-year period of pneumococcal vaccination of children.Methods.The quality of immunoprophylaxis of pneumococcal infection in the territory of the Russian Federation were assessed by analysing the coverage of vaccination and timeliness of its conduct after the inclusion of pneumococcal vaccine in the National Vaccination Schedule. The actual epidemiological efficacy of pneumococcal vaccination was assessed based on morbidity and mortality due to community-acquired pneumonia, incidence of acute otitis media among children. By questioning parents (n = 352) who applied to the Federal State Autonomous Institution of the Russian Federation Ministry of Health ‘National Medical Research Centre for Children’s Health, the timeliness of pneumococcal vaccination for infants was established.Results.In most regions, a high level of pneumococcal vaccination coverage was reached (87% of children). Despite the fact that the majority of children (73%) were vaccinated untimely. In particular, the results of a questionnaire survey conducted in the Moscow vaccination centre indicate insufficient awareness of parents for the need to vaccinate infants against pneumococcal infection by primary care professionals and, as a consequence, a low level of timely initiated vaccine introduction (40.1%). The introduction of routine prophylactic pneumococcal vaccination in Russia resulted in a 35% reduction in the death rate of children from community-acquired pneumonia, led to a decrease in the incidence of acute otitis media.Conclusion.The introduction of routine prophylactic vaccination of children against Streptococcus pneumoniae helps to reduce morbidity and mortality from pneumococcal infections. The surveillance system for community-acquired pneumonia requires further improvement. It is advisable to conduct an additional analysis on the reasons for refusals and medical exemptions to vaccination. It is important to increase the professional level of paediatricians in prophylactic vaccination.
Evaluation of the Physical Development of Children of Secondary School Age: аn Analysis of the Results of a Cross-Sectional Study
Authors: Namazova-Baranova Leyla S. , Yeletskaya Ksenia A. , Kaytukova Elena V. , Маkarova Svetlana G.
Published: October 2018

Background.Physical development is one of the leading criteria for assessing the health status of children. The body mass index (BMI) is a reliable sign of physical development disorders. The possibility of diagnosing childhood obesity, a significant problem of modern healthcare service, is of particular value. Our aim was to assess the prevalence of obesity, overweight, and underweight in students aged 11 and 15 years attending educational institutions in the regions of the Russian Federation.Methods.The data is based on a prospective assessment of the screening of children. A total of 2,540 children were examined, the study included data of 2,023 schoolchildren of both sexes aged 11 and 15 years. The BMI calculation was assessed using SDS tables and centile scales (WHO, 2007).Results.When assessing the body mass index in 11-year-old boys in the regions of Russia according to SDS, obesity was determined in 18.6% of cases, overweight — in 15.4% of cases, and underweight — in 5.4% of cases. In 15-year-old boys, obesity was detected in 10% of cases, overweight — in 11.5% of cases, and underweight — in 8.5% of cases. In girls aged 11 and 15 years, obesity was detected in 9.2% and 3.6% of cases, overweight — in 14.3% and 10.5% of cases, underweight — in 10.5% and 8.9% of cases, respectively.Conclusion.In the Russian Federation, cases of underweight or overweight were detected, but these indicators do not exceed the number of children with normal parameters. A high proportion of obese boys is detected mainly due to 11-year-olds. More cases of obesity were registered in girls aged comparing with 15-year-old girls.
Comment on the Аrticle «Possibilities of Magnetic Resonance Imaging of the Brain in Infantile Cerebral Palsy»
Authors: Klochkova Olga A. , Namazova-Baranova Leyla S.
Published: October 2018

.
The Role of Iron in the Pathogenesis of Autism Spectrum Disorders in Children
Authors: Kostina Olga V.
Published: October 2018

The review presents an analysis of the mechanisms of iron effect on the brain development. The importance of iron deficiency in the perinatal period is considered as a risk factor for the development of neuropsychiatric disorders in children with autism spectrum disorders (ASDs). Possible causes of sideropenia are discussed; data on haematological and biochemical parameters characterizing iron metabolism in children with ASDs are presented. The demand for studying the role of iron metabolism imbalance in the development of neuropsychiatric disorders in order to clarify pathogenetic mechanisms of ASDs and to determine methods for their correction is emphasized.
Switching to a Second TNF-_ Inhibitor in a Patient with Severe Juvenile Polyarthritis: A Clinical Case
Authors: Denisova Ekaterina V. , Alexeeva Ekaterina I. , Dvoryakovskaya Tatyana M. , Soloshenko Margarita A. , Mamutova Anna V. , Isayeva Kseniya B. , Fetisova Anna N.
Published: October 2018

Background. Insufficient efficacy or intolerance of the first TNF-_ inhibitor in patients with juvenile idiopathic arthritis (JIA) is an indication for the appointment of a second inhibitor. Golimumab is a new TNF-_ inhibitor registered for treating JIA under pediatric indications. Clinical Case Description. At an early age, the patient had an onset of polyarticular JIA. Due to the aggressive and rapidly progressive course, failure of therapy with nonsteroidal anti-inflammatory drugs, methotrexate and glucocorticosteroids for intra-articular administration, infliximab was prescribed to the patient, with a positive effect. Subsequently, the patient developed a secondary resistance to infliximab, inflammatory changes in the joints relapsed; thus, a second TNF-_ inhibitor (golimumab) was prescribed. In the course of therapy, pain and signs of arthritis in the patient were reversed, and the range of motion in the affected joints increased. After one year of therapy, JIA remission was ascertained. At the same time, the child was not administered oral glucocorticosteroids. The duration of remission of the joint syndrome was 5 years. Adverse events were not serious and did not constitute a basis for drug discontinuation. Conclusion. Switching to a second TNF-_ inhibitor (golimumab) was effective in a patient with a secondary resistance to the first TNF-_ inhibitor.
Mechanical and microstructural properties of GGBFS–RHA geopolymer concrete
Authors: Zabihi Seyed Mahmoud , Tavakoli Hamid Reza
Published: October 2018

The current study aims to evaluate the suitability of ground granulated blast-furnace slag (GGBFS)- and rice husk ash (RHA)-based geopolymer concrete for construction of structural elements by using high amounts of the industrial and agricultural solid wastes as raw materials. Compressive and splitting tensile strength, shrinkage and rapid chloride permeability tests were carried out to investigate the geopolymer’s properties. The test results indicated that replacement of cement with GGBFS–RHA-based geopolymer improved the mechanical properties of concrete and 100% replacement with the geopolymer can be considered as having the best results from environmental, structural and economic points of view. Furthermore, the curing time affected the compressive strength significantly. In addition, the carbon dioxide (CO2) emmision will be significant with the construction of studied sustainable GGBFS–RHA-based geopolymer composites. Moreover, from a microstructural point of view, total incorporation of GGBFS–RHA-based geopolymer in composites led to pore refinement in both the matrix and the interfacial zones and a reduction in the width of the interfacial transition zone between the paste and the aggregate, which could efficiently reduce water permeability.
WHERE DO RISKS IN SHRIMP FARMING COME FROM? EMPIRICAL RESULTS FROM SMALL FARMERS IN EAST JAVA, INDONESIA
Authors: Lestariadi Riski A. , Yamao Masahiro , Yamao Masahiro
Published: October 2018

This study was conducted to explore small-scaleshrimp farmers’ perception of risk and risk management. Thedata used originated from a field survey in the southern andnorthern coasts of East Java, Indonesia. According to the results,there are 32 risk sources, including shrimp price volatilityand high mortality due to shrimp diseases as the mostimportant ones. The exploratory factor analysis showed thatthe risks in small-scale shrimp farming derived from 8 factors:input and pond preparation; finance and credit access; production;personal aspects; harvesting and marketing; weather andenvironment; policy and institutional aspects; and businessenvironment. The results also revealed that the shrimp farmers’perception of risk could significantly influence their riskmanagement behavior. Furthermore, nine factors were identifiedfor risk management strategies, including disease prevention;education and technology improvement; productioninputs; farm management; government support; risk sharingand insurance; financial aspects; household adjustment; andalternative income sources.
EMPIRICAL ANALYSIS OF FOOD SECURITY STATUS OF AGRICULTURAL HOUSEHOLDS IN THE PLATINUM PROVINCE OF SOUTH AFRICA
Authors: Ijatuyi Enioluwa Jonathan , Omotayo Abiodun Olusola , Nkonki-Mandleni Busisiwe
Published: October 2018

This paper gives a succinct report on an investigationinto the food security constraints of rural farminghouseholds in the North West Province of South Africa. Datapresented was gathered across the four districts, and was analyzedusing descriptive statistics and inferential statistics. Thedescriptive results showed that the mean age of rural farmerswas 55 years and the average household size was 7 members.Logistic regression results on factors influencing foodsecurity in the study showed that variables such as age of thehousehold’s head, household feeding rate, the total cost ofproduction, farm income and health expenditure had significantimpact on the respondents’ food security (at p < 0.05).As shown by Probit regression results, constraints such as theage of household head, food availability, veld fires, marketavailability, predator invasion, health expenditure and veterinarypractices significantly influenced the achievement offood security in the study area. This study concluded that ruralfarming households were witnessing different dimensions offood insecurity which affected different aspects of their socialand economic activities. It is therefore the responsibility of thegovernment to come up with a holistic approach to addressthe present discrepancy in the national and grass-roots foodsecurity status.
LIQUIDITY AS A MEASURE OF EFFICIENCY OF FRUIT AND VEGETABLE PRODUCER GROUPS AND ORGANIZATIONS
Authors: Pawlak Joanna , Kopiński Łukasz , Paszko Dariusz , Banach-Albińska Barbara
Published: October 2018

This study attempts to assess the financial liquidityof fruit and vegetable producer groups and organizations.Based on static liquidity ratios, the analysis was used for a preliminaryassessment of the financial condition of the abovementionedeconomic operators in the context of forecastingtheir further market activity. Financial statements from 2012–2015 served as research material. The survey extended to 78groups and organizations of fruit and vegetable producers. Asshown by the results, most of the operators surveyed failed tomeet all the criteria of financial liquidity management. Theaverage and median values of current, quick and cash ratiossuggest that the operators face quite a high liquidity risk. Thiswas confirmed by the results of detailed studies which showedthat the liquidity ratios reported by ca. 60% of the operatorswere below the recommended optimum. Therefore, in the reportingperiod considered, such operators could be unable tomeet their liabilities as they fall due. This may pose a severethreat to their continued existence and further development.
SUCCESS FACTORS FOR MICRO AND SMALL AGRIBUSINESS ENTERPRISES (MSES) – THE CASE OF GHANA
Authors: Boakye Alfred Asuming , Ampadu-Ameyaw Richard , Owusu Essegbey George , Onumah Justina Adwoa
Published: October 2018

Micro and Small Enterprises (MSEs) are consideredto be engines of economic growth worldwide. Their efficiencyand competitiveness is critical to the creation of employment,income generation and poverty reduction and thereby to generalgrowth of the economy. However, studies on MSEs inGhana have mainly focused on the financial performance withlittle or no attention paid to the contribution of environmentaland socio-demographic factors to entrepreneurial success.The data for this study was obtained from Micro and SmallEnterprises (MSEs) in some twenty districts across Ghana.A total of 2899 entrepreneurs were interviewed. A binary logitregression was used in determining the impact of socio-demographicand environmental factors on entrepreneurial businesssuccess. As shown by the results, the odds of business successincrease by 67% if the formal education period is extendedby one year. Supportive environmental factors also significantlycontribute to business success. This study recommendsa policy that will help improving access to market for MSEs.Policy makers should consider strengthening the potential ofinstitutional support in terms of market information deliveredby public institutions to enhance the business success of agribusinessentrepreneurs in Ghana.Micro and Small Enterprises (MSEs) are consideredto be engines of economic growth worldwide. Their efficiencyand competitiveness is critical to the creation of employment,income generation and poverty reduction and thereby to generalgrowth of the economy. However, studies on MSEs inGhana have mainly focused on the financial performance withlittle or no attention paid to the contribution of environmentaland socio-demographic factors to entrepreneurial success.The data for this study was obtained from Micro and SmallEnterprises (MSEs) in some twenty districts across Ghana.A total of 2899 entrepreneurs were interviewed. A binary logitregression was used in determining the impact of socio-demographicand environmental factors on entrepreneurial businesssuccess. As shown by the results, the odds of business successincrease by 67% if the formal education period is extendedby one year. Supportive environmental factors also significantlycontribute to business success. This study recommendsa policy that will help improving access to market for MSEs.Policy makers should consider strengthening the potential ofinstitutional support in terms of market information deliveredby public institutions to enhance the business success of agribusinessentrepreneurs in Ghana.
Modernization Hypothesis and Neoliberalism
Authors: Shcherbak Svetlana
Published: October 2018

In this article, we discuss the modernization hypothesis in consideration of the causes of democratization related to economic development. The modernization hypothesis was formulated in the mid-twentieth century in the midst of specific economic and socio-political conditions. Since then, both societies and representations of their developments have changed. Current research disregards these transformations; therefore, with this work, we aim to fill the gap. We make clear how the neo-liberal turn influenced representations of economic development and democracy. Realization of the neo-liberal economic policy resulted in important social changes, particularly the rise of inequality and the wave of populism that endangers liberal democracy. At the same time, the modernization hypothesis is based on presumptions that economic development leads to income equalization and the creation of the broad middle class. Our analysis reveals that empirical surveys tend to confirm the relationship between economic development and democracy. However, economic growth does not necessarily entail more equal income distribution. The rise of populism indirectly confirms the rightness of the modernization hypothesis and suggests an important role for class dynamics. Democratization necessitates not only the establishment of liberal institutions but also the transformation of the social structure via convergence of incomes.
FARKLI ÜLKELERDEKİ ÖĞRENCİLERİN BİLGİ-İLETİŞİM TEKNOLOJİLERİNE AŞİNALIKLARININ ÇEŞİTLİ DEĞİŞKENLERE GÖRE SINIFLAMA DOĞRULUKLARININ İNCELENMESİ
Authors: Şengül Muharrem , Demir Ergül
Published: October 2018

Bu araştırmanın amacı, PISA 2012
uygulamasına katılan farklı matematik yeterlik düzeyindeki Türkiye, Yunanistan,
Portekiz ve Şanghay’daki 15 yaş grubu öğrencilerin bilgi iletişim teknolojileri
aşinalıklarının; öğrencilerin okul türü, sosyo-ekonomik düzey ve cinsiyetlerine
göre sınıflama doğruluklarını incelemektir. Araştırma korelasyonel araştırma
olarak yürütülmüş olup, araştırma sorularını yanıtlamak için çok değişkenli
varyans analizi (MANOVA) ve diskriminant fonksiyon analizi kullanılmıştır.
Araştırma sonuçlarına göre; genel olarak BİT aşinalık düzeyinin en yüksek
Portekiz’de olduğu, ikinci sırada bazı alt boyutlarda Türkiye’nin bazı alt
boyutlarda Yunanistan’ın yer aldığı, son sırada ise Şanghay’ın yer aldığı
bulunmuştur. Matematik dersinde bilgi iletişim teknolojileri kullanımında
Türkiye’nin diğer ülkelere göre manidar olarak yüksek indeks değerlerine sahip
olduğu bulunmuştur. Diskriminant fonksiyon analizi sonuçlarına göre; Türkiye,
Yunanistan, Portekiz ve Şanghay’da sırasıyla okul türüne göre %60.9, %83.6,
%61.2, %54; sosyo-ekonomik düzeye göre %56, %48.6, %50.2, %55.6; cinsiyetlere
göre %64.2, %58.4, %65.2, %57.5 sınıflama doğruluğu elde edilmiştir. Her ülkede
okul türü, sosyo-ekonomik düzey ve cinsiyetlere göre sınıflama doğruluğu
maksimum şans kriterine eşit veya bu kriterin üzerindedir. Bu sonuçlar; her
ülkede okul türü, sosyo-ekonomik düzey ve cinsiyetlere göre elde edilen
farkları desteklemekte ve yordayıcıların manidar olduğunu göstermektedir.
Seçmen Tercihlerinin Yönlendirilmesinde Değer Odaklı Argümantasyon Kullanımı
Authors: ÇALIŞKAN Osman , POYRAZ Emel
Published: October 2018

Seçmen tercihlerinin belirli bir siyasi kurum ya da görüş lehine yönlendirilmesi farklı bir çok teknikle yapılmaktadır. Bununla birlikte, seçmenin ikna edilmesi sürecinde siyasi kurumun ürettiği mesajın belirli mantıksal ilkelere göre tasarlanması da genel bir zorunluluktur. Bu doğrultuda politik argümantasyon, bir taraftan mesajın taşıması gereken mantıksal şartları karşılarken bir taraftan da belirli teknik yapılar ve üslup özellikleri sunmaktadır. Bununla paralel olarak bu araştırmada, seçmen tercihlerinin yönlendirilmesinde değer odaklı argümantasyon kullanımı incelenmiştir. Bu kapsamda, 2017 yılında yapılmış olan “Cumhurbaşkanlığı Hükümet Sistemi Referandumu” uygulama alanı olarak seçilmiştir. AK Parti ve CHP’nin referandum kampanyası dahilinde ürettiği yazılı materyalin değer odaklı argümantasyon bağlamında politik argümantasyon analizi yapılmıştır. Araştırma sonucunda, referandum konularına yönelik üretilen toplam yedi AK Parti argümanından üçünün, CHP’nin ise toplam dokuz argümanından ikisinin değer odaklı argümantasyon tarzına uygun olduğu tespit edilmiştir.
Perkütan endoskopik gastrostomi uygulamalarındaki tecrübelerimiz
Authors: DEMİRCİ Hakan , KİLCİLER Güldem , ÖZTÜRK Kadir , KANTARCIOĞLU Murat , UYGUN Ahmet , BAĞCI Sait
Published: October 2018

Giriş ve Amaç: Perkütan endoskopik gastrostomi uzun vadeli enteral nutrisyona gereksinim duyan hastalarda beslenme için tercih edilen yöntemdir. Bu çalışmanın amacı, perkütan endoskopik gastrostomi uygulanan hastaların özelliklerini retrospektif olarak analiz etmektir. Gereç ve Yöntem: Gülhane Askeri Tıp Akademisi, Gastroenteroloji Bilim Dalında 1999 ile 2014 yılları arasında perkütan endoskopik gastrostomi uygulanan hastaların endikasyonları, işlem detayları, takip süreleri ve gelişen komplikasyonlar retrospektif olarak değerlendirildi. Bulgular: Çalışmaya dahil edilen 642 hastanın 405’i (%63.1) erkek, 237’si (%36.9) kadındı. Hastaların ortalama yaşları 64.2 (18-97) yıl idi. Yedi hasta dışındaki tüm hastalara perkütan endoskopik gastrostomi başarıyla uygulandı. En sık perkütan endoskopik gastrostomi yerleştirme endikasyonu 495 (%77.1) hasta ile nörolojik hastalıklardı. Diğer endikasyonlar ise; 109 (%16.9) hastada orofaringeal hastalıklar ve 38 (%6) hastada özofageal hastalıklardı. Perkütan endoskopik gastrostomi prosedürüne bağlı 123 (%19.1) hastada komplikasyon gözlendi. Perkütan endoskopik gastrostomi sonrası 1 aylık dönem içinde 9 (%1.4) hasta, 3 ay içinde 15 (%2.3) hasta, 6 ay içinde ise 38 (%5.9) hasta ex oldu. Perkütan endoskopik gastrostomi yerleştirilmesine bağlı hiçbir hastada mortalite gözlenmedi. Sonuç: Perkütan endoskopik gastrostomi, beslenme desteğinin enteral olarak sağlanmasında güvenli, minimal invaziv, etkili, iyi tolere edilen ve düşük komplikasyon oranına sahip bir uygulamadır.
In Silico Study on N-Ferrocenylmethyl-N-Phenylpropionohydrazide and N-Ferrocenylmethyl-N-Pheylbenzohydrazide as Anticancer Drugs for Breast and Prostate Cancer
Authors: Nadjiba Zegheb , Chérifa Boubekri , Lanez Touhami , Lanez Elhafnaoui
Published: October 2018

Molecular docking calculations were used to evaluate the antitumor activities of N-ferrocenylmethyl-N-phenylpropanamide (FP) and N-ferrocenylmethyl-N-pheylbenzohydrazide (FH) against the enzymes of breast cancer 17-beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) and human steroidogenic cytochrome P450 17A1 prostate cancer mutant A105L (CYP17A1). The molecular docking study was performed using the open source AutoDock 4.2 software. The obtained results showed that both FP and FH bind with 17β-HSD1 and CYP17A1 via hydrogen bonds, binding free energy values for the adducts FH-17β-HSD1 and FH-CYP17A1 were respectively equal to-27.67 and-27.55 KJmol-1, while for the adducts FP-17β-HSD1 and FP-CYP17A1 they were respectively equal to-29.13 and 29.18 KJmol-1. The negative values and the magnitude of the obtained binding free energy indicated respectively the spontaneity and the electrostatic interaction of both ligands FP and FH with 17β-HSD1 and CYP17A1 receptors as the dominant mode. Finally the ligand FP binds more strongly to the receptor CYP17A1 and forms two respective hydrogen bonds with Arg96 and His373; this finding clearly indicate that FP is best qualified as potential drug candidature for breast and prostate cancer.
Knowledge and awareness on disaster management among medical professionals of a selected public and private medical college hospital
Authors: Rahman Atoshi Bazi , Chaklader Mainul Alam , Muhammad Faisal
Published: October 2018

Background: Disaster causes widespread destruction, disrupting people’s lives and causing human suffering with communities finding it difficult to cope. When the disaster occurs, human beings may not have the power to stop it from occurring, nevertheless they may have the power and ability to adapt or minimize the impact of the disaster on their lives. This study was aimed to assess the level of knowledge and awareness on disaster management among medical professionals.Methods: A cross-sectional study was conducted among the medical professionals from two selected medical college hospitals in Dhaka city of Bangladesh from January to April 2017. A total of 120 samples were selected purposively using two stages sampling technique. The data was collected using self-administered semi-structured questionnaire and was analysed using SPSS 20.0 version.Results: In this study half 60 (50.0%) of the study participants were in the age group 20-30 years and about 77.5% of the study participants were Muslims. About 64.2% of the study participants had less than 11 years of professional experience. Only 10 (8.3%) of the study participants had attended training on disaster management. About 30.0% of the study participants had good level of knowledge and only 49.2% had high level of awareness.Conclusions: The findings revealed that most of the study participants had not attended any training on disaster management. It also reported that the majority of the study participants had poor level of knowledge. Evacuation exercises need to be done for the entire hospital at least twice a year.
Carotid intima-media thickness and cardiovascular risk factors in childhood and adolescent obesity
Authors: Mahfouz Aml A. , Massoud Mohamed N. , Omar Omneya M. , Abou–Gabal Ahmed M.
Published: October 2018

Background: Childhood obesity is a significant health problem that has reached epidemic proportions around the world and it is a risk factor for atherosclerosis. The study aimed to investigate carotid intima-media thickness (CIMT) in obese children and evaluate the relationship of CIMT to various cardiovascular risk factors.Methods: This was achieved through including 40 obese children aged 5-16 years who were referred to Alexandria University Children's Hospital (AUCH) and 20 non-obese age and sex-matched children as the control group. All obese children in this study were subjected to thorough history taking, thorough clinical examination stressing on anthropometric measurement, blood pressure measurement and laboratory investigations including lipid profile, liver function tests, fasting glucose and fasting insulin and ultrasonographic study for the liver and carotid intima-media thickness measurement.Results: compared to the control, the obese children demonstrated a significantly thicker carotid intima-media (p<0.001). Univariate correlation analysis revealed that CIMT was significantly correlated with the body mass index (BMI), waist circumference measurement, diastolic blood pressure (DBP), high-density lipoprotein cholesterol (HDLC), fasting insulin, homeostasis model assessment- insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI) and fatty liver. In multiple linear regression analysis, CIMT correlated significantly with DBP in the obese group.Conclusions: Atherosclerosis begins in obese children and adolescents and CIMT measurement is a noninvasive, feasible, reliable and inexpensive method to detect subclinical atherosclerosis.
Toxicological Analysis of Insects on the Corpse: a Valuable Source of Information in Forensic Investigations
Authors: Salimi Mojtaba , Rassi Yavar , Chatrabgoun Omid , Kamali Artin , Ali Oshaghi Mohammad , Shiri-Ghaleh Vida , Moradi Mehrdad , Rafizadeh Sayena , Akbarzadeh Kameran , Zahra Parkhideh Seyedeh
Published: October 2018

Background: Entomotoxicology as a subset of forensic entomology can be used by analysis of carcass feeding in­sects to detecting of drugs or toxins, as well as the cause and manner of death in cases of ante-mortem drugs intoxi­cation. Morphine is one of the deacetylate metabolites of heroin. The aim of this study was to determine the presence and quantity of morphine in insects on the carcass and compare them with decomposing carcass.
Methods: Field of this study was in Chalabeh District and toxicological tests were carried out at the Department of Forensic Toxicology, Legal Medicine Center, Kermanshah, Iran in 2017. Morphine was inoculated into live rabbit as experimental model at concentrations of 12.5, 25, 50mg/ml, similar to those normally encountered in human over­doses, then quality and quantity of morphine were determined in insects such as Chrysomya albiceps (as the first wave of insect succession on human cadavers) fed on carcass.
Results: Quantitative assessment at larvae showed that morphine was detected in all larvae (feeding and post feeding stage) fed on tissues from carcasses administered morphine, except for post-feeding larvae from R1 which received 12.5mg/ml dosage of morphine.
Conclusions: Necrophagous insects are an indicator on the scene of crime and a potential source of information about the antemortem situation. Detection of drug in insects which is actually a reflection of the cause of death is possible.
Cross-Genera PCR Amplification of DNA from Apicomplexan Parasites
Authors: Gil de Mendonça Philippe
Published: October 2018

Background: The discovery of an unexpected genetic sequence raised doubts about the specificity of a primer pair targeting Babesia spp. and Theileria spp. This study aimed to check the specificity of this primer pair.
Methods: Conventional end-point PCR and real-time PCR protocols using primers targeting the 18S rRNA gene V4 hypervariable region of Babesia spp. and Theileria spp. were tested for potential cross-genera amplification using DNA from a palette of parasitic protists and pathogenic bacteria as a template. These investigations took place at the Ludwig Maximilian University of Munich (Germany) in 2010 as part of the EDEN project.
Results: Successful amplification was obtained with DNA from five apicomplexan genera: Babesia, Theileria, Hepa­tozoon, Toxoplasma, and Hammondia. No amplicons were obtained when DNA from Leishmania infantum or bacte­ria within the genera Borrelia, Leptospira or Anaplasma was used as a template.
Conclusion: This cross-genera amplification ability is useful for the quick exclusion of many parasite species from PCR negative diagnostic samples. Accurate species identification from PCR positive samples requires genetic se­quencing of the amplicon.
Cómo abordar la preeclampsia en el momento actual
Authors: Garzón-Olivares Carmen Doris , Bautista-Charry Alejandro A.
Published: October 2018

En la Antigua Grecia se creía que el cuerpo humano estaba constituido por cuatro tipos de humores y que el desbalance entre ellos llevaba a la enfermedad. La mujer era considerada más vulnerable de presentar dolencias, por tener una súper producción de sus fluidos y presentar un “útero errante” que podría irrumpir en sus diferentes órganos y llevarla aún a convulsionar durante el embarazo (1). Hipócrates el padre de la Medicina, pensaba que las convulsiones durante el embarazo se producían por congestión o por depleción sanguínea del cerebro (2).Durante la Edad Media dominaron las creencias religiosas. Se utilizaron amuletos, pociones mágicas y oraciones de sanidad (1). Para tratar de disminuir la congestión cerebral y prevenir la eclampsia, Mauriceau recomendó realizar de dos a tres flebotomías durante el embarazo y magnificó en sus escritos la naturaleza crítica de la enfermedad (3).Al final del siglo 19 y comienzo del 20, los médicos alemanes y de los países bajos realizaban un manejo agresivo de la eclampsia, desembarazando de manera inmediata por vía vaginal o abdominal. Esta conducta obstétrica agresiva incrementó de manera notable la mortalidad materna. Como resultado empezó a ganar popularidad el manejo conservador de la eclampsia (4). Los pioneros de este método fueron Tweedy de Dublin y Stroganoff de  Rusia (1). El primero consideraba que el trabajo de parto incrementaba la ocurrencia de convulsiones por mecanismos reflejos. El médico debía abstenerse de realizar exámenes vaginales, palpación abdominal, dilatación del cérvix. La paciente debía sedarse con altas dosis de morfina. Si se entraba en trabajo de parto la aplicación del fórceps era aceptada (5).
Estudo e Validação Experimental de um Conversor Multinível Modular Entrelaçado CA-CC Monofásico Para Aplicações de Transformadores de Estado Sólido
Authors: Joca Davi R. , Barreto Luiz H. S. C. , Jr. Demercil de S. Oliveira , Vannier Jean-C. , Džonlaga Bogdan , Quéval Loïc
Published: October 2018

Este artigo tem como objetivo apresentar o estudo teórico e a obtenção de resultados experimentais de uma topologia monofásica baseada em um conversor multinível modular entrelaçado. A estrutura pode ser empregada como o estágio ca-cc em aplicações de transformador de estado sólido. O objetivo é a conexão entre uma rede elétrica ca de média tensão e uma rede cc de baixa tensão. A nova técnica de entrelaçamento divide as correntes através das pernas do conversor multinível modular e é responsável pela modulação de tensão nos submódulos. O transformador de média frequência de 10 kHz fornece isolação galvânica e conecta o conversor multinível modular entrelaçado a um conversor de ponte completa. As características do conversor são discutidas, considerando a estrutura, o princípio de operação, a técnica de modulação e o esquema de controle. O sistema de controle regula a corrente de entrada e a tensão de barramento, no lado de alta tensão, e a tensão de saída e o fluxo de potência bidirecional, no lado de baixa tensão. A validação experimental do conversor é feita com um protótipo de pequena escala.
Trzy pytania o polską socjologię sportu
Authors: Nosal Przemysław
Published: October 2018

W dwóch wydanych niedawno publikacjach pod redakcją Kevina Younga (2016, 2017) przedstawiony został światowy pejzaż socjologii sportu. Autorzy poszczególnych rozdziałów tej publikacji, reprezentujący różne państwa, zostali poproszeni o opisanie rodzimego statusu tej subdyscypliny w oparciu o zbiór pytań kluczowych dla jej scharakteryzowania. Wśród analizowanych krajów nie pojawia się jednak Polska. Niniejszy tekst jest zatem próbą opisania kondycji polskiej socjologii sportu przez pryzmat trzech jej aspektów: przeszłości, teraźniejszości i przyszłości.
Determination of Pesticide Residues in Grapes From Vineyards Implemented Good Agricultural Practice in Uşak
Authors: Zengin Erdal , Karaca İsmail
Published: October 2018

This
study was conducted to determine pesticides residue levels in grapes samples
which taken from vineyards implemented good agricultural practice in Uşak province
in 2017 growing seasons. A total of 51 grape samples from three districts were
collected. Liquid chromatography with mass spectrometry (LC-MS/MS) and gas
chromatography with mass spectrometry (GC-MS/MS) devices were used for all
analyses. In 45.1% of the samples taken weren’t detected any pesticide residue.
In 54.9% of grape samples found residue, none of this pesticides exceeded the
maximum residue limits given in Turkish Food Codex. The most common pesticides
detected in grape samples with residue were spinosad, pyrimethanil and boscalid
respectively. Thirteen different pesticide active substances were detected
below the MRL in the samples. All pesticides detected in the samples were
fungicides (85%) and insecticides (15%).
Enjeux et outils du traitement raisonné contre les strongles gastro-intestinaux chez les bovins et les petits ruminants
Authors: RAVINET N. , CHARTIER C. , HOSTE H. , MAHIEU M. , DUVAUCHELLE-WACHE A. , MERLIN A. , BAREILLE N. , JACQUIET P. , CHAUVIN A.
Published: October 2018

Chez les ruminants élevés au pâturage, les strongles gastro-intestinaux (SGI) peuvent induire des pertes de production, voire des atteintes cliniques chez les animaux non immuns. Le contrôle de l’infestation repose essentiellement sur les traitements anthelminthiques (AH) administrés fréquemment sans évaluation préalable de la réalité du risque parasitaire. Cette synthèse vise tout d’abord à exposer les principaux risques associés à ce recours insuffisamment raisonné aux AH : apparition de populations de parasites résistants aux AH, écotoxicité pour la microfaune prairiale dégradant les fèces, et installation retardée de l’immunité anti-strongles (notamment chez les bovins). Les stratégies de traitement ciblé-sélectif devraient permettre de maîtriser ces risques tout en prévenant les atteintes cliniques et sécurisant les performances des animaux. Il s’agit de rationaliser les traitements AH en ciblant les troupeaux ou les lots et les périodes à risque, et en sélectionnant les individus les plus parasités ou « souffrant » le plus du parasitisme. Cette synthèse vise donc ensuite à décrire les outils et les indicateurs étudiés pour mettre en œuvre de telles stratégies chez les ruminants. Il s’agit d’indicateurs zootechniques (gain moyen quotidien, parité, niveau de production…), cliniques (FAMACHA©, index de diarrhée…), parasitologiques (coproscopie, niveau d’anticorps anti-SGI…), ou d’indicateurs de conduite (modalité de pâturage), et aussi d’outils informatiques (modélisation du recyclage parasitaire). Leur fiabilité et leur opérationnalité sont variables. La mise en place de telles stratégies nécessitera de dépasser les freins à l’acceptation de ces nouvelles pratiques tant au niveau des éleveurs que des vétérinaires prescripteurs. Cet usage raisonné des AH assurerait une meilleure durabilité du contrôle de l’infestation par les SGI.
Particularités de la reproduction des vaches allaitantes de races françaises
Authors: GRIMARD B. , AGABRIEL J. , CHAMBON G. , CHANVALLON A. , CONSTANT F. , CHASTANT S.
Published: October 2018

La reproduction des vaches allaitantes présente des particularités par rapport à celle des vaches laitières. Améliorer leur reproduction est un levier pour augmenter leur productivité. Les génisses de race à viande sont pubères lorsqu’elles ont atteint 50-55% du poids adulte vs 40-45% chez les génisses laitières. Les premières peuvent être mises à la reproduction vers 70% du poids adulte contre 60% pour les secondes. Le taux de renouvellement est assez faible en élevage allaitant, de 18 à 30% selon les races. Après le vêlage, la durée de l’anœstrus postpartum est plus longue qu’en race laitière du fait de la tétée du veau. L’expression des chaleurs est bonne chez la vache allaitante : les chaleurs durent entre 6 et 10 h dans les 3 principales races (Charolaise, Limousine et Blonde d’Aquitaine), et l’acceptation du chevauchement est exprimée dans 90 à 100% des œstrus. La monte naturelle domine en élevage allaitant : seuls 3 à 24% des veaux sont issus d’insémination selon les races. La fertilité des vaches allaitantes est actuellement mal connue, la performance de reproduction est plutôt approchée par la fécondité : l’intervalle vêlage-vêlage moyen des troupeaux est compris entre 379 et 444 jours selon les races. La proportion de vaches atteintes d’endométrite après vêlage semble élevée chez la vache allaitante comme chez la vache laitière (environ 20% même au-delà de 50 jours postpartum) mais les effets de cette affection sur la reproduction ont été peu explorés. De nombreuses données françaises concernant les races à viande spécialisées et rustiques sont présentées dans cet article.
Les échanges de bovins vivants et de viande bovine dans le monde et dans l’UE : trajectoires productives et commerciales des principaux pays impliqués
Authors: CHATELLIER V.
Published: October 2018

L’augmentation de la consommation de viande bovine dans plusieurs pays asiatiques contribue à renforcer les jeux concurrentiels entre les principaux exportateurs mondiaux de viande bovine, dont l’Australie, l’Inde, le Brésil ou les États-Unis. Les principaux importateurs de viande bovine, dont les États-Unis, la Chine (avec Hong-Kong), le Japon et la Russie, connaissent des trajectoires différenciées en fonction de l’évolution de la demande intérieure en viande bovine, des conditions sanitaires propres aux pays fournisseurs et, parfois, de questions géopolitiques. L’Union Européenne, qui connait à la fois une baisse de sa production et de sa consommation de viande bovine, n’est pas un acteur majeur du commerce international dans ce secteur. La demande intérieure est satisfaite essentiellement par des produits européens, mais des flux importants de bovins vivants et de viande bovine ont lieu entre les États membres. En utilisant les bases de données des douanes disponibles, tant à l’échelle mondiale (« Comtrade » et « Baci ») que de l’Union Européenne (« Comext »), cet article propose une analyse sur l’évolution de la situation productive et commerciale des principaux acteurs du secteur bovin mondial pour la période 2000 à 2015.
Des services contrastés rendus par l’élevage dans les espaces urbains et périurbains européens
Authors: DELFOSSE C. , DUMONT B. , HOSTIOU N.
Published: October 2018

L’élevage dans les espaces urbains et périurbains trouve actuellement un net regain d’intérêt en Europe du fait de l’intérêt croissant des consommateurs autour du « produire local » et du besoin de « nature » des citadins. Notre objectif est ici de synthétiser une littérature souvent fragmentaire et de structurer cette analyse grâce au cadre des bouquets de services. Pour les espaces périurbains, la littérature scientifique traite en priorité des enjeux d’aménagement pour répondre à l’approvisionnement alimentaire des villes. L’élevage en ville est bien moins étudié, ce qui nous a conduits à utiliser quelques travaux hors Europe et à consulter les sites internet de communautés urbaines et des sites associatifs. Les bouquets de services rendus par l’élevage et les freins à son développement sont très différents entre ces deux types d’espaces. Dans les villes d’Europe de l’Ouest le service d’approvisionnement reste minoritaire. La réintroduction des animaux en ville est largement motivée par une volonté de créer du lien social et constitue un facteur de réinsertion et d’éducation des citadins vis-à-vis de l’origine des produits qu’ils consomment. Les principaux freins sont liés aux nuisances et aux risques épidémiologiques occasionnés par les animaux. Dans les espaces périurbains, la contribution de l’élevage au service d’approvisionnement est plus importante et dynamisée par la vente directe. L’élevage d’herbivores maintient des prairies qui fournissent différents services de régulation et répondent aux attentes des citadins pour des espaces récréatifs à proximité immédiate des villes. Le développement de l’élevage est principalement contraint par la forte pression foncière qui s’exerce sur ces espaces. Nous concluons en proposant quelques pistes de recherches.
Productions et activités équines en France : quelles contributions à la durabilité de l’agriculture ?
Authors: BIGOT Geneviève , VIAL Céline , FLEURANCE Géraldine , HEYDEMANN Pascale , PALAZON Roger
Published: October 2018

Le cheptel équin français est estimé à 1 million de têtes, ce qui le place toutefois, loin derrière les cheptels de bovins et d’ovins. Les poneys et chevaux de selle pour le sport et les loisirs équestres représentent les 2/3 des effectifs. Le seul secteur des courses réalise un chiffre d’affaire de l’ordre de 10 milliards d’euros. Quelle que soit l’orientation (élevage, pension, entraînement, centre équestre…), la présence d’équins dans les structures est principalement motivée par la passion des dirigeants pour cet animal, si bien que la limite entre loisir et activité productive n’est pas toujours claire. Cet aspect influe sur l’atomisation de la filière, le temps consacré aux animaux et les objectifs économiques des exploitants, ainsi que sur leur perception par le reste du monde agricole. Cette motivation peut néanmoins expliquer, pourquoi les productions et activités équines sont présentes sur tout le territoire national où elles contribuent à l’image et à l’attractivité des zones rurales et suburbaines. Les spécificités intrinsèques de cet herbivore lui permettent de valoriser des surfaces en herbe non exploitables par les bovins ou en complément de ceux-ci. La présence de chevaux contribue ainsi à la préservation de ressources naturelles et de la biodiversité. L’illustration des différents impacts - économiques, sociaux et environnementaux - des productions et activités équines dans le secteur agricole devrait contribuer à une meilleure lisibilité de cette filière par la profession agricole et ses interlocuteurs publics permettant ainsi son intégration dans les stratégies d’évolution de l’agriculture vers plus de durabilité.