bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Human Visual Sensory Stimuli on N1b Amplitude: An EEG Study
Authors: Moore Damien , Ikuta Toshikazu , Loprinzi Paul D.
Published: September 2020

Sensory systems are widely known to exhibit adaptive mechanisms. Vision is no exception to input dependent changes in its sensitivity. Recent animal work demonstrates enhanced connectivity between neurons in the visual cortex. The purpose of the present experiment was to evaluate a human model that noninvasively alters the amplitude of the N1b component in the visual cortex of humans by means of rapid visual stimulation. Nineteen participants (Mage = 24 years; 52.6% male) completed a rapid visual stimulation paradigm involving black and white reversal checkerboards presented bilaterally in the visual field. EEG data was collected during the visual stimulation paradigm, which consisted of four main phases, a pre-tetanus block, photic stimulus, early post-tetanus, and late post-tetanus. The amplitude of the N1b component of the pre-tetanus, early post-tetanus and late post-tetanus visual evoked potentials were calculated. Change in N1b amplitude was calculated by subtracting pre-tetanus N1b amplitude from early and late post-tetanus. Results demonstrated a significant difference between pre-tetanus N1b (M = −0.498 µV, SD = 0.858) and early N1b (M = −1.011 µV, SD = 1.088), t (18) = 2.761, p = 0.039, d = 0.633. No difference was observed between pre-tetanus N1b and late N1b (p = 0.36). In conclusion, our findings suggest that it is possible to induce changes in the amplitude of the visually evoked potential N1b waveform in the visual cortex of humans non-invasively. Additional work is needed to corroborate that the potentiation of the N1b component observed in this study is due to similar mechanisms essential to prolonged strengthened neural connections exhibited in cognitive structures of the brain observed in prior animal research. If so, this will allow for the examination of strengthened neural connectivity and its interaction with multiple human sensory stimuli and behaviors.
Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients
Authors: Zamzam Abdelrahman , Syed Muzammil H. , Greco Elisa , Wheatcroft Mark , Jain Shubha , Khan Hamzah , Singh Krishna K. , Forbes Thomas L. , Rotstein Ori , Abdin Rawand , Qadura Mohammad
Published: September 2020

Diabetic patients with peripheral arterial disease (PAD) often suffer from poor clinical outcomes such as limb-loss. Fatty acid binding protein 4 (FABP4) is mainly expressed by adipocytes and is known to play a significant role in the development of atherosclerosis. In this study, we sought to investigate whether FABP4 is associated with PAD in patients with type 2 diabetes mellitus (DM). FABP4 plasma levels were studied in 119 diabetic patients with PAD (DM-PAD) and 49 diabetic patients without PAD (DM-noPAD) presenting to St. Michael’s Hospital between October 2017 and September 2018. Levels of FABP4 in DM-PAD patients (23.34 ± 15.27 ng/mL) were found to be over two-fold higher than the levels in DM-noPAD patients (10.3 ± 7.59 ng/mL). Regression analysis demonstrated a significant association between FABP4 levels and DM-PAD after adjusting for age, sex, prior history of coronary arterial disease and white blood cells count (OR, 2.77; 95% CI, 1.81–4.31; p-value = 0.001). Relative to DM-noPAD controls, plasma FABP4 levels in DM-PAD patients were noted to be inversely correlated with the ankle brachial index (ABI; r= −0.374, p-value < 0.001). The diagnostic ability of FABP4 was investigated using receiver operator curves (ROC) and area under the curve (AUC) analysis. FABP4 had an AUC of 0.79, which improved to 0.86 after adjusting for age, sex and prior history of coronary arterial disease. This raises a possibility of utilizing FABP4 as a biomarker for diagnosing PAD in diabetic patients.
Comparison of 2-Year Outcomes between Intravitreal Ranibizumab and Intravitreal Aflibercept for Diabetic Macular Edema with “Treat-and-Extend” Regimen—Its Usefulness and Problems
Authors: Chujo Shinichiro , Sugimoto Masahiko , Sasaki Taku , Matsui Yoshitsugu , Kato Kumiko , Ichio Atsushi , Miyata Ryohei , Matsubara Hisashi , Kondo Mineo
Published: September 2020

Background: To compare the effectiveness of intravitreal ranibizumab (IVR) and intravitreal aflibercept (IVA) performed with the treat-and-extend (TAE) regimen on eyes with diabetic macular edema (DME). Patients and methods: This is a retrospective study of 125 eyes of 125 treatment-naïve DME patients who received anti-VEGF injections at three consecutive monthly intervals as the loading phase. The changes in the best-corrected visual acuity (BCVA), central retinal thickness (CRT), diabetic retinopathy severity scale (DRSS), and total injection numbers were compared between the two anti-VEGF agents. Results: Among 125 eyes, 26 eyes completed the treatment with the TAE regimen for 24 months (20.8%). Thirteen eyes of 13 patients (mean age, 70.9 ± 6.0 years) received intravitreal injections of 0.5 mg ranibizumab, and 13 eyes of 13 patients (65.9 ± 8.6 years) received 2 mg aflibercept. No significant differences were detected in the baseline demographics. At 24 months, BCVA was significantly improved in both groups; from 0.31 ± 0.19 to 0.10 ± 0.12 logMAR units for IVR and 0.41 ± 0.19 to 0.16 ± 0.28 logMAR units for IVA (p = 1.29 × 10−9). CRT was significantly reduced in both groups; 440.9 ± 69.3 to 307.5 ± 66.4 μm for IVR and 473.9 ± 71.5 to 317.8 ± 71.2 μm for IVA (p = 3.55 × 10−9). No significant differences were detected in the improvements of BCVA, CRT in both groups, and the total injection numbers for 24 months (11.0 ± 1.2 for the IVA group and 12.0 ± 1.0 the IVR group). DRSS was significantly improved in both groups (p = 0.0004 for IVR and p = 0.009 for IVA). Conclusion: No significant differences were detected in the improvements of BCVA or CRT and injection numbers between the IVR and IVA groups treated with the TAE regimen. These results indicate that the results of the treatment with both agents with the TAE regimen were equally effective, but only 20.8% of patients completed 24 months of continuous treatment with the TAE regimen. Synopsis: There are no significant differences regarding effectiveness between the IVR and IVA groups treated with the TAE regimen for DME eyes.
Evaluation of In Vivo Spike Detection Algorithms for Implantable MTA Brain—Silicon Interfaces
Authors: Tambaro Mattia , Vallicelli Elia Arturo , Saggese Gerardo , Strollo Antonio , Baschirotto Andrea , Vassanelli Stefano
Published: September 2020

This work presents a comparison between different neural spike algorithms to find the optimum for in vivo implanted EOSFET (electrolyte–oxide-semiconductor field effect transistor) sensors. EOSFET arrays are planar sensors capable of sensing the electrical activity of nearby neuron populations in both in vitro cultures and in vivo experiments. They are characterized by a high cell-like resolution and low invasiveness compared to probes with passive electrodes, but exhibit a higher noise power that requires ad hoc spike detection algorithms to detect relevant biological activity. Algorithms for implanted devices require good detection accuracy performance and low power consumption due to the limited power budget of implanted devices. A figure of merit (FoM) based on accuracy and resource consumption is presented and used to compare different algorithms present in the literature, such as the smoothed nonlinear energy operator and correlation-based algorithms. A multi transistor array (MTA) sensor of 7 honeycomb pixels of a 30 μm2 area is simulated, generating a signal with Neurocube. This signal is then used to validate the algorithms’ performances. The results allow us to numerically determine which is the most efficient algorithm in the case of power constraint in implantable devices and to characterize its performance in terms of accuracy and resource usage.
Toxin Production by Stachybotrys chartarum Genotype S on Different Culture Media
Authors: Ulrich Sebastian , Schäfer Cornelius
Published: September 2020

Stachybotrys (S.) chartarum had been linked to severe health problems in humans and animals, which occur after exposure to the toxic secondary metabolites of this mold. S. chartarum had been isolated from different environmental sources, ranging from culinary herbs and improperly stored fodder to damp building materials. To access the pathogenic potential of isolates, it is essential to analyze them under defined conditions that allow for the production of their toxic metabolites. All Stachybotrys species are assumed to produce the immunosuppressive phenylspirodrimanes, but the highly cytotoxic macrocyclic trichothecenes are exclusively generated by the genotype S of S. chartarum. In this study, we have analyzed four genotype S strains initially isolated from three different habitats. We grew them on five commonly used media (malt-extract-agar, glucose-yeast-peptone-agar, potato-dextrose-agar, cellulose-agar, Sabouraud-dextrose-agar) to identify conditions that promote mycotoxin production. Using LC-MS/MS, we have quantified stachybotrylactam and all S-type specific macrocyclic trichothecenes (satratoxin G, H, F, roridin E, L-2, verrucarin J). All five media supported a comparable fungal growth and sporulation at 25 °C in the dark. The highest concentrations of macrocyclic trichothecenes were detected on potato-dextrose-agar or cellulose-agar. Malt-extract-agar let to an intermediate and glucose-yeast-peptone-agar and Sabouraud-dextrose-agar to a poor mycotoxin production. These data demonstrate that the mycotoxin production clearly depends on the composition of the respective medium. Our findings provide a starting point for further studies in order to identify individual components that either support or repress the production of mycotoxins in S. chartarum.
Carbon Storage Potential of Silvopastoral Systems of Colombia
Authors: Aynekulu Ermias , Suber Marta , van Noordwijk Meine , Arango Jacobo , Roshetko James M. , Rosenstock Todd S.
Published: September 2020

Nine Latin American countries plan to use silvopastoral practices—incorporating trees into grazing lands—to mitigate climate change. However, the cumulative potential of scaling up silvopastoral systems at national levels is not well quantified. Here, we combined previously published tree cover data based on 250 m resolution MODIS satellite remote sensing imagery for 2000–2017 with ecofloristic zone carbon stock estimates to calculate historical and potential future tree biomass carbon storage in Colombian grasslands. Between 2000 and 2017, tree cover across all Colombian grasslands increased from 15% to 18%, with total biomass carbon (TBC) stocks increasing from 0.41 to 0.48 Pg. The range in 2017 carbon stock values in grasslands based on ecofloristic zones (5 to 122 Mg ha−1) suggests a potential for further increase. Increasing all carbon stocks to the current median and 75th percentile levels for the respective eco-floristic zone would increase TBC stocks by about 0.06 and 0.15 Pg, respectively. Incorporated into national C accounting, such Tier 2 estimates can set realistic targets for silvopastoral systems in nationally determined contributions (NDCs) and nationally appropriate mitigation actions (NAMAs) implementation plans in Colombia and other Latin American countries with similar contexts.
Optimisation of the Thin-Walled Composite Structures in Terms of Critical Buckling Force
Authors: Szklarek Karol , Gajewski Jakub
Published: September 2020

The paper presents the optimisation of thin-walled composite structures on a representative sample of a thin-walled column made of carbon laminate with a channel section-type profile. The optimisation consisted of determining the configuration of laminate layers for which the tested structure has the greatest resistance to the loss of stability. The optimisation of the layer configuration was performed using two methods. The first method, divided into two stages to reduce the time, was to determine the optimum arrangement angle in each laminate layer using finite element methods (FEM). The second method employed artificial neural networks for predicting critical buckling force values and the creation of an optimisation tool. Artificial neural networks were combined into groups of networks, thereby improving the quality of the obtained results and simplifying the obtained neural networks. The results from computations were verified against the results obtained from the experiment. The optimisation was performed using ABAQUS® and STATISTICA® software.
Effects of Steel-Slag Components on Interfacial-Reaction Characteristics of Permeable Steel-Slag–Bitumen Mixture
Authors: Liu Wenhuan , Li Hui , Zhu Huimei , Xu Pinjing
Published: September 2020

In this paper, a permeable steel-slag–bitumen mixture (PSSBM) was first prepared according to the designed mixture ratio. Then, the interaction characteristics between steel slag and bitumen were studied. The chemical interaction between bitumen and steel slag was explored with a Fourier-transform infrared spectrometer (FT-IR). The influence of steel-slag chemistry, mineral composition, and bitumen reaction on phase angle, complex shear modulus (CSM), and rutting factor was explored with dynamic shear rheological (DSR) tests. The PSSBM had better properties, including high permeability, water stability, Marshall stability, high-temperature (HT) stability, and low volume-expansion rate. Bitumen-coated steel slag can prevent heavy-metal ions from leaching. In the infrared spectra of the mixture of a chemical component of steel slag (calcium oxide) and bitumen, a new absorption peak at 3645 cm−1 was ascribed to the SiO–H stretching vibration, indicating that new organic silicon compounds were produced in the chemical reaction between calcium oxide and bitumen. SiO–H had an obvious enhancement effect on the interfacial adhesion and high-temperature rheological property of the mixture. In the mineral components of steel slag, dicalcium and tricalcium silicate reacted with bitumen and generated new substances. Chemical reactions between tricalcium silicate and bitumen were significant and had obvious enhancement effects on interfacial adhesion and high-temperature rheological properties of the mixture. The results of FT-IR and DSR were basically consistent, which revealed the chemical-reaction mechanism between steel-slag microcomponents and bitumen at the interface. SEM results showed that pits and grooves on the surface of the steel-slag aggregate, and the textural characteristics provide a framework-like function, thus strengthening the strength and adhesion of the steel-slag–bitumen aggregate interface.
Intelligent Automation System on a Single-Board Computer Platform for the Agro-Industrial Sector
Authors: Butsenko Elena , Kurdyumov Aleksandr , Semin Aleksandr
Published: September 2020

The latest technologies in agribusiness include a range of IT solutions that reduce manual intervention with the top priority tasks to improve, develop, and implement projects based on smart agriculture, which operates on the principles of automation and robotization of production. The aim of the study is to develop a system of automated control of business processes for an agricultural enterprise. The system allows for remote collection and processing of data on technical and economic performance of the farming enterprise. It proves to be a low-cost solution due to the use of affordable and available equipment. When designing the system, the authors described its back end, as well as the connectivity architecture between sensors and modules on one side, and the microcontroller on the other. The paper features modules for monitoring and controlling electrical energy consumption, lighting, temperature, and humidity written in C ++ programming language. Test modules that were controlled by the Arduino microcontroller were analyzed. Further development of the system may involve devising and introducing IoT technologies based on the use of various architectural platforms for practical application.
Nonlinear Position Control Using Differential Flatness Concept with Load Torque Observer for Electro Hydraulic Actuators with Sinusoidal Load Torque
Authors: Suh Sangmin , Kim Wonhee
Published: September 2020

We propose a nonlinear position control using a differential flatness concept with a load torque observer to compensate for the sinusoidal load torque in electro-hydraulic actuators (EHAs) EHAs. In an EHA with a rotational joint, the load torque is a sinusoidal disturbance, whose magnitude can be estimated via a load torque observer. In the proposed load torque observer, the load torque can be estimated without requiring its maximum frequency to be known. The position controller tracks position and comprises an inner-loop load pressure controller and an outer-loop position controller. The former tracks the desired pressure via near input–output linearization. The desired pressure is developed using the differential flatness of the mechanical system in the EHA. The feedback plus feedforward outer-loop position controller is designed to track the desired position and to compensate for the load torque. The stability of the closed-loop system is mathematically proven using the input-to-state stability property.
Integration of Simulation Driven DfAM and LCC Analysis for Decision Making in L-PBF
Authors: Nyamekye Patricia , Unt Anna , Salminen Antti , Piili Heidi
Published: September 2020

Laser based powder bed fusion (L-PBF) is used to manufacture parts layer by layer with the energy of laser beam. The use of L-PBF for building functional parts originates from the design freedom, flexibility, customizability, and energy efficiency of products applied in dynamic application fields such as aerospace and automotive. There are challenges and drawbacks that need to be defined and overcome before its adaptation next to rivaling traditional manufacturing methods. Factors such as high cost of L-PBF machines, metal powder, post-preprocessing, and low productivity may deter its acceptance as a mainstream manufacturing technique. Understanding the key cost drivers of L-PBF that influence productivity throughout the whole lifespan of products will facilitate the decision-making process. Functional and operational decisions can yield profitability and increase competitiveness among advanced manufacturing sectors. Identifying the relationships between the phases of the life cycle of products influences cost-effectiveness. The aim of the study is to investigate the life cycle cost (LCC) and the impact of design to it in additive manufacturing (AM) with L-PBF. The article provides a review of simulation driven design for additive manufacturing (simulation driven DfAM) and LCC for metallic L-PBF processes and examines the state of the art to outline the merits, demerits, design rules, and life cycle models of L-PBF. Practical case studies of L-PBF are discussed and analysis of the interrelating factors of the different life phases are presented. This study shows that simulation driven DfAM in the design phase increases the productivity throughout the whole production and life span of L-PBF parts. The LCC model covers the whole holistic lifecycle engineering of products and offers guidelines for decision making.
Soil Type Affects Organic Acid Production and Phosphorus Solubilization Efficiency Mediated by Several Native Fungal Strains from Mexico
Authors: Zúñiga-Silgado Dorcas , Rivera-Leyva Julio C. , Coleman Jeffrey J. , Sánchez-Reyez Ayixon , Valencia-Díaz Susana , Serrano Mario , de-Bashan Luz E. , Folch-Mallol Jorge L.
Published: September 2020

Phosphorus (P) is considered a scarce macronutrient for plants in most tropical soils. The application of rock phosphate (RP) has been used to fertilize crops, but the amount of P released is not always at a necessary level for the plant. An alternative to this problem is the use of Phosphorus Solubilizing Microorganisms (PSM) to release P from chemically unavailable forms. This study compared the P sorption capacity of soils (the ability to retain P, making it unavailable for the plant) and the profile of organic acids (OA) produced by fungal isolates and the in vitro solubilization efficiency of RP. Trichoderma and Aspergillus strains were assessed in media with or without RP and different soils (Andisol, Alfisol, Vertisol). The type and amount of OA and the amount of soluble P were quantified, and according to our data, under the conditions tested, significant differences were observed in the OA profiles and the amount of soluble P present in the different soils. The efficiency to solubilize RP lies in the release of OAs with low acidity constants independent of the concentration at which they are released. It is proposed that the main mechanism of RP dissolution is the production of OAs.
Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense
Authors: Beck Katharina , Ohno Hiroshi , Satoh-Takayama Naoko
Published: September 2020

Innate lymphoid cells (ILCs) are a recently discovered type of innate immune lymphocyte. They include three different groups classified by the nature of the transcription factors required for their development and by the cytokines they produce. ILCs mainly reside in tissues close to the mucosal barrier such as the respiratory and gastrointestinal tracts. Due to their close proximity to the mucosal surface, ILCs are exposed to a variety of both commensal and pathogenic bacteria. Under non-pathological conditions, ILCs have been shown to be important regulators for the maintenance of tissue homeostasis by mutual interactions with the microbiome. Besides these important functions at homeostasis, several studies have also provided emerging evidence that ILCs contribute to defense against pathogenic bacterial infection by responding rapidly to the pathogens as well as orchestrating other immune cells. In this review, we summarize recent advances in our understanding of the interactions of ILCs and bacteria, with special focus on the function of the different ILC subsets in bacterial infections.
Non-Empirical Large-Scale Search for Optical Metasurfaces
Authors: Iwanaga Masanobu
Published: September 2020

Metasurfaces are artificially designed, on-top, thin structures on bulk substrates, realizing various functions in recent years. Most metasurfaces have been conceived of for attaining optical functions, based on elaborate human knowledge-based designs for complex structures. Here, we introduce a method for a non-empirical, large-scale structural search to find optical metasurfaces, which enable us to access intended functions without depending on human knowledge and experience. This method is different from the optimization and modification reported so far. To illustrate the outputs in the non-empirical search, we show unpredictable, optically high-performance, all-dielectric metasurfaces found in the machine search. As an extension of the finding of a higher order diffractive structure, we furthermore show a light-focusing metadevice, which is diffraction-limited and has the unique feature that the focal length is almost invariant even when the distance from the incident spot to the metadevice largely varies.
Off-Resonant Absorption Enhancement in Single Nanowires via Graded Dual-Shell Design
Authors: Liu Wenfu , Guo Xiaolei , Xing Shule , Yao Haizi , Wang Yinling , Bai Liuyang , Wang Qi , Zhang Liang , Wu Dachuan , Zhang Yuxiao , Wang Xiao , Yi Yasha
Published: September 2020

Single nanowires (NWs) are of great importance for optoelectronic applications, especially solar cells serving as powering nanoscale devices. However, weak off-resonant absorption can limit its light-harvesting capability. Here, we propose a single NW coated with the graded-index dual shells (DSNW). We demonstrate that, with appropriate thickness and refractive index of the inner shell, the DSNW exhibits significantly enhanced light trapping compared with the bare NW (BNW) and the NW only coated with the outer shell (OSNW) and the inner shell (ISNW), which can be attributed to the optimal off-resonant absorption mode profiles due to the improved coupling between the reemitted light of the transition modes of the leak mode resonances of the Si core and the nanofocusing light from the dual shells with the graded refractive index. We found that the light absorption can be engineered via tuning the thickness and the refractive index of the inner shell, the photocurrent density is significantly enhanced by 134% (56%, 12%) in comparison with that of the BNW (OSNW, ISNW). This work advances our understanding of how to improve off-resonant absorption by applying graded dual-shell design and provides a new choice for designing high-efficiency single NW photovoltaic devices.
Non-Coding RNA Databases in Cardiovascular Research
Authors: Balamurali Deepak , Stoll Monika
Published: September 2020

Cardiovascular diseases (CVDs) are of multifactorial origin and can be attributed to several genetic and environmental components. CVDs are the leading cause of mortality worldwide and they primarily damage the heart and the vascular system. Non-coding RNA (ncRNA) refers to functional RNA molecules, which have been transcribed into DNA but do not further get translated into proteins. Recent transcriptomic studies have identified the presence of thousands of ncRNA molecules across species. In humans, less than 2% of the total genome represents the protein-coding genes. While the role of many ncRNAs is yet to be ascertained, some long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been associated with disease progression, serving as useful diagnostic and prognostic biomarkers. A plethora of data repositories specialized in ncRNAs have been developed over the years using publicly available high-throughput data from next-generation sequencing and other approaches, that cover various facets of ncRNA research like basic and functional annotation, expressional profile, structural and molecular changes, and interaction with other biomolecules. Here, we provide a compendium of the current ncRNA databases relevant to cardiovascular research.
Dietary Oxalate Intake and Kidney Outcomes
Authors: Bargagli Matteo , Tio Maria Clarissa , Waikar Sushrut S. , Ferraro Pietro Manuel
Published: September 2020

Oxalate is both a plant-derived molecule and a terminal toxic metabolite with no known physiological function in humans. It is predominantly eliminated by the kidneys through glomerular filtration and tubular secretion. Regardless of the cause, the increased load of dietary oxalate presented to the kidneys has been linked to different kidney-related conditions and injuries, including calcium oxalate nephrolithiasis, acute and chronic kidney disease. In this paper, we review the current literature on the association between dietary oxalate intake and kidney outcomes.
Prevalence and Socio-Demographic Predictors of Food Insecurity in Australia during the COVID-19 Pandemic
Authors: Kent Katherine , Murray Sandra , Penrose Beth , Auckland Stuart , Visentin Denis , Godrich Stephanie , Lester Elizabeth
Published: September 2020

The COVID-19 pandemic has exacerbated economic vulnerabilities and disrupted the Australian food supply, with potential implications for food insecurity. This study aims to describe the prevalence and socio-demographic associations of food insecurity in Tasmania, Australia, during the COVID-19 pandemic. A cross-sectional survey (deployed late May to early June 2020) incorporated the U.S. Household Food Security Survey Module: Six-Item Short Form, and fifteen demographic and COVID-related income questions. Survey data (n = 1170) were analyzed using univariate and multivariate binary logistic regression. The prevalence of food insecurity was 26%. The adjusted odds of food insecurity were higher among respondents with a disability, from a rural area, and living with dependents. Increasing age, a university education, and income above $80,000/year were protective against food insecurity. Food insecurity more than doubled with a loss of household income above 25% (Adjusted Odds Ratio (AOR): 2.02; 95% CI: 1.11, 3.71; p = 0.022), and the odds further increased with loss of income above 75% (AOR: 7.14; 95% CI: 2.01, 24.83; p = 0.002). Our results suggest that the prevalence of food insecurity may have increased during the COVID-19 pandemic, particularly among economically vulnerable households and people who lost income. Policies that support disadvantaged households and ensure adequate employment opportunities are important to support Australians throughout and post the COVID-19 pandemic.
Traits of Orthorexia Nervosa and the Determinants of These Behaviors in Elite Athletes
Authors: Surała Olga , Malczewska-Lenczowska Jadwiga , Sadowska Dorota , Grabowska Izabela , Białecka-Dębek Agata
Published: September 2020

Background: The purpose of this study was to evaluate the traits of orthorexia nervosa (ON) and its relation to body composition and anthropometric indices among elite athletes. Methods: We studied 273 (125 female, 148 male) competitive athletes. ON was assessed with the self-administered ORTO-15 questionnaire. Total body composition was determined using dual-energy X-ray absorptiometry (DXA). Results: The ORTO-15 score was independent of sex, type of effort or age. The ORTO-15 score was related to: total body mass (TBM) (p = 0.037; R = 0.170), body mass index (BMI) (p = 0.022; R = 0.187), bone mineral content (BMC) (p = 0.035; R = 0.172), lean soft tissue (p = 0.026; R = 0.182) and visceral adipose tissue (VAT) (p = 0.007; R = 0.255) in the male; BMI (p = 0.045; R = 0.412) and BMC (p = 0.012; R = 0.506) in weight-dependent male athletes. There was no relationship between ORTO-15 score and body composition in the total study group and subgroup of female athletes. In female athletes, ON tendencies were related to the weekly training time (p = 0.039), but in sprint and high-intensity intermittent efforts subgroup exclusively. Conclusions: Factors related to ON tendencies concerned exclusively BMI and body composition in male, and the weekly training time in female athletes. The results from this study demonstrate that a significant percentage of athletes, irrespective of sex, age, type of sport or hours of training per week, may manifest traits of orthorexia nervosa.
Pharmacokinetic Comparison of Three Different Administration Routes for Topotecan Hydrochloride in Rats
Authors: Jeong Seung-Hyun , Jang Ji-Hun , Lee Yong-Bok
Published: September 2020

Topotecan is actively used in clinic, with its primary use being in treatment of various types of cancer. The approved administration routes are oral and intravenous. The purpose of this study was to investigate and identify pharmacokinetic profiles of different administration routes. We conducted pharmacokinetic studies on three different routes of administration in rats. Five rats in each group received a single dose of 4 mg/kg of topotecan hydrochloride intravenously, orally, or subcutaneously, and the concentrations of lactone and total forms of the drug in plasma, urine, and feces were quantified. Various pharmacokinetic parameters were compared statistically. Plasma concentrations of both the lactone and total forms at elimination phase following subcutaneous administration, were two times higher than was seen with oral administration and 10 times higher than with intravenous administration. Subcutaneous administration of topotecan showed pharmacokinetic profiles similar to sustained release. In addition, subcutaneous administration showed bioavailability from 88.05% (for lactone form) to 99.75% (for total form), and these values were four–five times greater than those of oral administration. The results of this non-clinical study will not only provide greater understanding of the in vivo pharmacokinetics of topotecan, but also be useful for development of additional formulations and/or administration routes.
A New Nano-Platform of Erythromycin Combined with Ag Nano-Particle ZnO Nano-Structure against Methicillin-Resistant Staphylococcus aureus
Authors: Naskar Atanu , Lee Sohee , Lee Yunhee , Kim Semi , Kim Kwang-sun
Published: September 2020

Nano-particles have been combined with antibiotics in recent studies to overcome multidrug-resistant bacteria. Here, we synthesized a nano-material in which Ag nano-particles were assembled with a ZnO nano-structure to form an Ag-ZnO (AZO) nano-composite at low temperature. This material was combined with erythromycin (Ery), an antibiotic effective towards gram-positive bacteria, using three different approaches (AZO + Ery (AZE) [centrifuged (AZE1), used separately after 1-h gap (AZE2), without centrifugation (AZE3)]) to prepare a nano-antibiotic against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). X-ray diffraction analysis and transmission electron microscopy confirmed the presence of Ag nano-particles and ZnO nano-structure. The elemental and chemical state of the elements present in the AZO nano-composite were assessed by X-ray photoelectron spectroscopy. The antibacterial activity of AZE samples against both Escherichia coli and S. aureus strains including MRSA was evaluated in antibacterial and morphological analyses. The AZE3 sample showed greater antibacterial activity than the other samples and was comparable to erythromycin. AZE3 was ~20-fold less prone to developing bacterial resistance following multiple exposures to bacteria compared to erythromycin alone. The AZE3 nano-composite showed good biocompatibility with 293 human embryonic kidney cells. Our newly synthesized nano-platform antibiotics may be useful against multidrug-resistant gram-positive bacteria.
Tea Tree Oil Induces Systemic Resistance against Fusarium wilt in Banana and Xanthomonas Infection in Tomato Plants
Authors: Dalio Ronaldo J. D. , Maximo Heros J. , Roma-Almeida Rafaela , Barretta Janaína N. , José Eric M. , Vitti Agnelo J. , Blachinsky Daphna , Reuveni Moshe , Pascholati Sérgio F.
Published: September 2020

The essential tea tree oil (TTO) derived from Melaleuca alternifolia plant is widely used as a biopesticide to protect crops from several plant-pathogens. Its activity raised queries regarding its ability to, not only act as a bio-fungicide or bio-bactericide, but also systemically inducing resistance in plants. This was examined by TTO application to banana plants challenged by Fusarium oxysporum f. sp. cubense (Foc, Race 1) causing Fusarium wilt and to tomato plants challenged by Xanthomonas campestris. Parameters to assess resistance induction included: disease development, enzymatic activity, defense genes expression correlated to systemic acquired resistance (SAR) and induced systemic resistance (ISR) and priming effect. Spraying TTO on field-grown banana plants infected with Foc and greenhouse tomato plants infected with Xanthomonas campestris led to resistance induction in both hosts. Several marker genes of salicylic acid, jasmonic acid and ethylene pathways were significantly up-regulated in parallel with symptoms reduction. For tomato plants, we have also recorded a priming effect following TTO treatment. In addition to fungicidal and bactericidal effect, TTO can be applied in more sustainable strategies to control diseases by enhancing the plants ability to defend themselves against pathogens and ultimately diminish chemical pesticides applications.
Editorial for the Special Issue “Selected Papers from the 16th International Conference on Squeezed States and Uncertainty Relations (ICSSUR 2019)”
Authors: Sánchez-Soto Luis L. , Man’ko Margarita A.
Published: September 2020

The first quantum revolution started in the early 20th century and gave us new rules that govern physical reality [...]
A Method for an Integrated Sustainability Assessment of RFID Technology
Authors: Gladysz Bartlomiej , Ejsmont Krzysztof , Kluczek Aldona , Corti Donatella , Marciniak Stanislaw
Published: September 2020

Industry 4.0 (I4.0) has become a widely accepted manufacturing paradigm across a wide range of industries. It includes an array of various approaches, tools, techniques, and methods. They were known to researchers before, but when combined they build a new reality, which needs procedures for the assessment of technologies and manufacturing processes. Current assessment methods often fail to incorporate economic, environmental, and social impacts simultaneously in an integrated way. The potential implementation of a sustainability assessment procedure on a larger scale is seen for (well-developed) Radio Frequency Identification (RFID) technology. The measures for assessment were identified through a literature review and validated by expert panels. Validation measures were quantified using multi-criteria decision making (AHP). Criteria ranking was used for reasoning if the assumed modular structure responded to the experts’ needs. To connect the existing research gap, a holistic and integrated assessment method for I4.0 applications, depicted in a structured way and tailored for RFID technology, is developed, which constitutes a research gap in current literature on this topic. Results showed that a modularized structure of approach (module—group of measures—measures [as indicators]) for RFID sustainability assessment, which depends on the complexity of this technology, may be a convenient method for assessment of I4.0 technologies. It was confirmed that all sustainability perspectives are important due to their contributions to supporting decisions and should be considered in the assessment of RFID. On the other hand, it can help managers and practitioners implement the assessment method in their practice to reduce pollution and save the environment.
A Case Study of the Retention Efficiency of a Traditional and Innovative Drainage System
Authors: Starzec Mariusz , Dziopak Józef
Published: September 2020

To determine the effectiveness of the retention capacity utilization of traditional and innovative drainage systems equipped with damming partitions, the detailed model tests were carried out. The research results allowed indicating what values of the hydraulic parameter of the innovative drainage system should be adopted in order to effectively use the retention capacity of drainage collectors. The adoption of short distances between the LKR damming partitions and a high level of permissible rainfall of stormwater Hper turned out to be the most effective solution. In the most favorable conditions, the peak flow was reduced by up to 60% (717.46 dm3/s) compared to the values established in the traditional drainage system (1807.62 dm3/s). The benefits obtained resulted from the increased retention efficiency of the drainage system after equipping it with the damming partitions. It was found that the innovative system always achieved the maximum retention capacity with longer rainfall compared to the traditional system. In the real catchment area, an increase in the use of the retention capacity of the drainage system, from an initial value of 65% for a traditional system to almost 88% for an innovative system, was also found. Very large variability of the volume of accumulated stormwater in the conduits of the traditional and innovative drainage system was observed during rainfall, which generated the peak rainfall discharge in the innovative system. With rainfall of TRK duration, the innovative system accumulated up to 746.50 m3 more stormwater compared to a traditional system, which was 49.2% of the total retention capacity of the drainage system, with a value of 1515.76 m3. The approach to reduce the growing flood risk in cities provided the right approach to long-term urban drainage system planning, especially since traditional drainage systems are still the leading way to transport stormwater in cities. In addition, the innovative sewage system gives the possibility of favorable cooperation with any objects (LID) and retention tanks with any hydraulic model. The implementation of an innovative system allows achieving significant financial savings and reducing the need to reserve areas designated for infrastructure investments.
Diurnal to Seasonal Variations in Ocean Chlorophyll and Ocean Currents in the North of Taiwan Observed by Geostationary Ocean Color Imager and Coastal Radar
Authors: Hsu Po-Chun , Lu Ching-Yuan , Hsu Tai-Wen , Ho Chung-Ru
Published: September 2020

The waters in the north of Taiwan are located at the southern end of the East China Sea (ECS), adjacent to the Taiwan Strait (TS), and the Kuroshio region. To understand the physical dynamic process of ocean currents and the temporal and spatial distribution of the ocean chlorophyll concentration in the north of Taiwan, hourly coastal ocean dynamics applications radar (CODAR) flow field data and geostationary ocean color imager (GOCI) data are analyzed here. According to data from December 2014 to May 2020, the water in the TS flows along the northern coast of Taiwan into the Kuroshio region with a velocity of 0.13 m/s in spring and summer through the ECS. In winter, the Kuroshio invades the ECS shelf, where the water flows into the TS through the ECS with a velocity of 0.08 m/s. The seasonal variation of ocean chlorophyll concentration along the northwestern coast of Taiwan is obvious, where the average chlorophyll concentration from November to January exceeds 2.0 mg/m3, and the lowest concentration in spring is 1.4 mg/m3. It is apparent that the tidal currents in the north of Taiwan flow eastward and westward during ebb and flood periods, respectively. Affected by the background currents, the flow velocity exhibits significant seasonal changes, namely, 0.43 m/s in summer and 0.27 m/s in winter during the ebb period and is 0.26 m/s in summer and 0.45 m/s in winter during the flood period. The chlorophyll concentration near the shore is also significantly affected by the tidal currents. Based on CODAR data, virtual drifter experiments, and GOCI data, this research provides novel and important knowledge of ocean current movement process in the north of Taiwan and indicates diurnal to seasonal variations in the ocean chlorophyll concentration, facilitating future research on the interaction between the TS, ECS, and Kuroshio.
An Assessment on the Technical and Economic Feasibility of Mechanized Rice Straw Collection in the Philippines
Authors: Balingbing Carlito , Van Hung Nguyen , Roxas Ampy Paulo , Aquino Daniel , Barbacias Mary Grace , Gummert Martin
Published: September 2020

The increasing utilization of rice combine harvesters in the Philippines has made collection of scattered rice straw difficult and laborious. While there are high demands for using rice straw, e.g., for feed or mushroom production, rice straw is predominantly burned in the field due to labor shortages and the high manual cost of collection, particularly for scattered rice straw harvested by combine harvesters. This study conducted an assessment and evaluated the feasibility of mechanized collection of rice straw by comparing the performance of two types of baler (i.e., roller and piston type) for two seasons—2019 wet and dry seasons at the International Rice Research Institute (IRRI) and in Nueva Ecija, the Philippines. The study collected data on fuel consumption, manpower requirements, and field capacity by operating the balers to collect scattered rice straw in the field and piled rice straw that was left in the field after threshing. The round baler operated at 35% lower effective field capacity (EFC) on piled rice straw than on scattered rice straw, while the square baler operated at 2.33 times and 5.79 times higher EFC compared with the round baler on piled and scattered rice straw, respectively. The square baler used for collecting scattered rice straw is more appropriate under Philippine conditions, with a significantly lower baling cost by about 68% and an average EFC that is 4.43 times higher compared to the round baler. With the increasing demand for rice straw as feedstock for ruminants and for other alternative uses, using mechanical balers to gather scattered rice straw in the field is a sustainable option for farmers to utilize the straw for value-adding purposes. This is a foremost study conducted in the Philippines to guide policy makers, development workers, and end-users on the suitability of either square balers or round balers to gather scattered rice straw in the field after rice harvesting with combines.
Trace Mineral Leaching from Equine Compost
Authors: Fowler Ashley L. , Brummer-Holder Mieke , Dawson Karl A.
Published: September 2020

Mineral leaching from compost can be environmentally disruptive. Little information is available regarding trace mineral leaching from equine-sourced compost. The objective of this study was to quantify the mineral content and leaching potential of compost produced from feces of horses fed different amounts and forms (organic or inorganic) of trace minerals. Nine horses were fed three treatments in a 3 × 3 replicated Latin Square design. The dietary treatments were provided as a daily pellet: CON (pellet without added trace minerals), ING (added inorganic trace minerals), and ORG (added organic trace minerals). The added trace minerals were Co, Cu, Mn, and Zn. Feces were collected from each horse after a 16-day feeding period, combined with straw, composted, and then subjected to simulated rainfall to measure mineral mobility. Concentrations of Co, Cu, Mn, and Zn were greater in ING and ORG compared to CON compost (p < 0.05); additionally, ING had greater Zn than ORG compost (p < 0.05). More Cu leached from ING and ORG compared to CON (p < 0.05). The most Zn leached from ING, followed by ORG, and the least amount leached from CON compost (p < 0.05). Dietary trace mineral intake affected the trace mineral concentration in the compost and amount available to leach during rainfall events.
Entrepreneurial Orientation (EO), Integrated Marketing Communications (IMC), and Performance in Small and Medium-Sized Enterprises (SMEs): Gender Gap and Inter-Country Context
Authors: Butkouskaya Vera , Llonch-Andreu Joan , Alarcón-del-Amo María-del-Carmen
Published: September 2020

Expanding and maintaining the number of Small and Medium-sized Enterprises (SMEs) is directly related to sustainable economic, social, and individual development. However, SMEs are vulnerable to competition. Thus, this study focusses on the analysis of entrepreneurial orientation (EO) as an antecedent of integrated marketing communications’ (IMC) successful implementation directed at improving SMEs’ performance, with additional focus on the institutional inter-country context. Considering the role of owner-managers in SMEs, analysis of the gender gap is also applied. The data from 315 managers’ surveys (in Spain and Belarus) is analyzed using Structural Equation Modelling (SEM). The results show a positive relationship between EO, IMC, and performance among SMEs in both markets. However, these connections are significantly stronger in the case of male, rather than female managers in a developed market (Spain). There is no gender gap in an emerging market (Belarus). Moreover, and conversely, in a developing market, the EO-IMC-performance relations are more intensive when the manager is female. Further implementations are provided for practitioners and government organizations with a focus on the gender gap and inter-country differences.