bluuebunny/crossref_metadata_2025 huggingface dataset:
Empagliflozin ameliorates ventricular arrhythmias by inhibiting sympathetic remodeling via nerve growth factor/tyrosine kinase receptor A pathway inhibition
Authors: Jing Yuling , Ding Yanling , Fu Hengsong , Li Tao , Long Ting , Ye Qiang
Published: July 2024

Background and aims

Sodium-glucose cotransporter 2 inhibitors (SGLT2is) can ameliorate arrhythmias; however, the mechanisms underlying their antiarrhythmic effect remain unclear. Therefore, we aimed to test the hypothesis that the SGLT2i empagliflozin (EMPA) ameliorates ventricular arrhythmias caused by myocardial infarction (MI) by inhibiting sympathetic remodeling.

Methods

Male nondiabetic Sprague–Dawley rats were divided into Sham (n = 10), MI (n = 13), low-EMPA (10 mg/kg/day; n = 13), and high-EMPA (30 mg/kg/day; n = 13) groups. Except for the Sham group, MI models were established by ligation of the left anterior descending coronary artery. After 4 weeks, the hearts were removed. Echocardiography, electrical stimulation, hematoxylin–eosin staining and Masson's staining, Western blotting, immunohistochemistry (IHC), and ELISA were performed.

Results

Except for left ventricular posterior wall thickness (LVPWT), EMPA treatment significantly ameliorated the left ventricular anterior wall thickness (LVAWT), interventricular septum thickness (IVST), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), and left ventricular ejection fraction (LVEF) in MI rats; there was no statistical difference between the low-EMPA and high-EMPA groups. The threshold for ventricular fibrillation induction and myocardial fibrosis was significantly ameliorated in EMPA-treated rats, and there was no statistical difference between the high-EMPA and low-EMPA groups. EMPA decreased the expression of nerve growth factor (NGF), tyrosine kinase receptor A (TrkA), tyrosine hydroxylase, and growth-associated protein 43 (GAP43) in the left ventricular infarction margin myocardium of MI rats, especially in the high-EMPA group, with a statistically significant difference between the high-EMPA and low-EMPA groups. High-EMPA significantly decreased noradrenaline (NE) levels in the blood of MI rats; however, there was no statistical difference between the low-EMPA and MI groups.

Conclusion

EMPA ameliorated the occurrence of ventricular arrhythmias in MI rats, which may be related to a reduction in sympathetic activity, inhibition of the NGF/TrkA pathway, inhibition of sympathetic remodeling, and improvement in cardiac function and cardiac structural remodeling.
Country risk and political risk under investigation – recent trends, prospects, and implications
Authors: Andreica Ioana Sorina , Bodea Gabriela , Deceanu Liviu Daniel
Published: July 2024

For many years, economic growth has been one the main objectives of economies around the world. Recently, the central focus has diverted from the quantitative to the qualitative approach. Mainstream research acknowledged that institutional quality along with country risk is among the most significant factors that contribute to the achievement of high economic development rates. Country risk is associated with the probability that investors or companies from a certain country will face greater instability or losses and includes financial, economic, and political risks. Lower political risk ranks first in the category of main drives that enable countries to attract more foreign direct investments and allow markets to operate efficiently. This article examined the recent evolutions in terms of the concept and main antecedents of the political risks, considering the current negative disruptions that economies were forced to experience, covering aspects related to health, wars, and economic downturns. The analysis identified that a high political risk negatively impacts demographics, environment, and the health system. The ability of countries to bounce back and develop a strong resilient economy toward adverse shocks depends on the institutional quality and the effectiveness of policymakers, who are responsible for elaborating efficient economic policies.
Innovative Strategy for The Improvement of Competences in the Area of Science
Authors: Carrasco-Acosta Marina , Guerra-Santana Mónica , Rodríguez-Pulido Josefa , Garcia-Jimenez Pilar
Published: July 2024

Objective: To design and implement a cooperative experience in the higher education institution in a subject of the Bachelor's Degree in Chemical Engineering carried out over five academic years.
 
Theoretical Framework: Higher education today calls for innovation processes that facilitate the improvement of student learning.
 
Method: A learning experience based on the Kolb cycle and the seminar was designed and implemented. The evaluation of the experience was carried out using the Learning Oriented Assessment (LOA) model, together with a questionnaire compiling the evaluations expressed by the students, according to the Likert scale.
 
Results and Discussion: The results revealed that students consider that the key to learning development lies in the distribution of tasks and the ability to work actively and autonomously.
 
Research Implications: The practical and theoretical implications of the study are discussed, providing higher education institutions with a learning strategy to improve competences in the area of science through innovation tools.
 
Originality/Value: This research highlights innovative tools that favour the development of the cognitive skills of analysis, critical thought, internalization of concepts and consolidation of part of the contents of the subject, without forgetting the communicative skills and self-learning of the student.
A relevância da objeção de consciência na percepção dos novos direitos no Brasil
Authors: Q. O. Feres Ribeiro Débora
Published: July 2024

Este artigo exporá a partir de um assunto ainda pouco explorado no âmbito jurídico, a saber, a objeção de consciência aferido por José Carlos Buzanello como “um viver de acordo com sua consciência, pautar a própria conduta pelas convicções religiosas, políticas e filosóficas. Dela decorre que cada ser humano tem o direito de conduzir a própria vida como “melhor entender”, desde que não fira o direito de terceiros”. Embora seja um tema de acentuado relevo no direito constitucional brasileiro, de tal maneira que possui estabilidade nos direitos fundamentais inclusive em determinadas Constituições estrangeiras, aponta-se na brasileira nos artigos 5º, inciso VIII, e artigo 143, § 1º, da Constituição Federal, possui pouca percepção na sociedade jurídica assim como na sociedade civil. A partir desse desconhecimento é que, se faz necessário verificar que, tal fenômeno possui a imperativa necessidade de ser efetivado a partir de seu reconhecimento e estudo entre operadores do direito de maneira interdisciplinar que ampare as situações em que, o objetor consiga manifestar livremente sua liberdade de escolher sua posição em conformidade a suas convicções, prestigiando a sua autonomia da vontade e dignidade humana em todas as esferas profissionais em que possa revelar-se o direito a seu não fazer.
El compromiso perenne de Francesco Rosi en su cine más contemporáneo, a través de su obra Dimenticare Palermo (Olvidar Palermo)
Authors: Longhi Ludovico , Ramon Pinat Ezequiel
Published: July 2024

A lo largo de su obra, el director de cine Francesco Rosi adoptó un compromiso político sobre los temas de actualidad que aquejaban a toda Italia, especialmente al sur del país. En una de sus últimas obras, Dimenticare Palermo (1990), se adentra en la relación entre política y mafia. Condicionado por los temas que trata, sus películas acaban por adoptar una narrativa cercana al cine negro. Contemporáneo al debate de aquel entonces, se posiciona a favor de una legalización controlada de las drogas, aunque el enfrentamiento con el PSI que propugnaba una postura diferente, haya hecho peligrar su proyecto.
Estado do conhecimento sobre os desafios dos professores alfabetizadores em tempos de pandemia
Authors: Nunes Luana Thais , Zancanaro Airton
Published: July 2024

Este artigo tem o objetivo de discutir sobre os desafios dos professores alfabetizadores durante o período de pandemia, quando da suspensão das aulas presenciais. Reconhecendo a alfabetização como uma importante etapa para a aprendizagem e com o intuito de buscar estudos na literatura, foram realizadas pesquisas em bases de dados científicas para compor o estado do conhecimento. A partir dos relatos encontrados na literatura, foram identificados os desafios, possibilitando categorizá-los por áreas para uma melhor compreensão, sendo essas: Tecnologia, Avaliação, Cultura, Social, Saúde, Econômica e Ambiente Educacional. Os resultados apresentados revelam uma notável falta de investimentos e ações oriundos do poder público, fazendo com que cada local se organizasse de maneira diferente. Constatou-se que os professores alfabetizadores não estavam preparados para dar continuidade às aulas de maneira remota, tendo que se adaptar sem prévia preparação e poucos recursos. Espera-se contribuir com estudos futuros, fornecendo uma base de conhecimento sobre os desafios enfrentados pelos professores de alfabetização durante a pandemia.
EDUKASI MANFAAT NUTRISI BAGI TUMBUH KEMBANG GIGI DAN MULUT ANAK USIA PRA SEKOLAH PADA MURID TK ADZKIA III DI KOTA PADANG
Authors: Sovira Gita Dwi Jiwanda , Putri Wulandani Liza , Kasuma Nila
Published: July 2024

Kesehatan gigi anak sangat penting untuk menjamin status gizi anak, kemampuan berbicara dan penampilan yang menarik. Gizi, diet dan kesehatan gigi pada anak memiliki kaitan yang erat, terutama pada anak yang sedang dalam fase tumbuh kembang. Gizi yang baik dan tepat sangat penting untuk menunjang kesehatan gigi. Begitupun sebaliknya, kesehatan gigi juga penting untuk asupan nutrisi yang adekuat. Jika gigi dan mulut sehat, maka intake nutrisi akan optimal, dan jika nutrisi maksimal maka tumbuh kembang gigi dan mulut pun akan optimal. Sebanyak 89% persen anak-anak di Indonesia menderita penyakit gigi. Sejumlah survei menunjukkan bahwa lebih dari sepertiga penduduk balita pernah mengalami sakit gigi dan seperenam diantaranya pernah melakukan pencabutan setidaknya satu gigi. Pertumbuhan dan perkembangan gigi dipengaruhi oleh nutrisi. Pertumbuhan gigi yang sehat akan terjadi apabila seluruh unsur nutrisi tersedia dalam jumlah yang cukup. Tujuan kegiatan: memberikan edukasi pada anak usia dini mengenai pentingnya nutrisi bagi tumbuh kembang gigi dan mulut. Metode kegiatan yang digunakan yaitu metode tell-show- do dengan presentasi menggunakan media power point, poster, model gigi dan sikat gigi, serta pemeriksaan gigi dan mulut anak. Metode ini merupakan salah satu metode yang paling tepat dalam memberikan edukasi pada anak usia dini. Hasil kegiatan: bertambahnya pengetahuan anak yang dan timbulnya rasa berani saat dilakukan pemeriksaan gigi oleh dokter gigi. Kesimpulan: Kegiatan ini berdampak positif bagi anak usia dini karena anak menjadi lebih paham bahwa ada keterkaitan antara nutrisi dengan kesehatan gigi dan mulut.
PELATIHAN MANAJEMEN USAHA DALAM UPAYA PENGEMBANGAN USAHA BORDIR DI NAGARI SINGGALANG KABUPATEN TANAH DATAR
Authors: Andriani Yessy , Anggraeni Dian Yuni , Dewi Laksmi
Published: July 2024

Kegiatan ini bertujuan untuk memberikan pelatihan manajemen usaha pada usaha bordir di nagari Singgalang, Tanah Datar. Hal ini dilakukan agar usaha dapat dikelola dengan baik sehingga memberikan keuntungan usaha yang baik. Metode yang digunakan dalam kegiatan ini adalah metode ceramah dan pelatihan. Metode ceramah diberikan dalam bentuk penyuluhan dengan menggunakan teknik public participative dan woman participative dalam ekonomi. Metode ini memfokuskan pelatihan pada perempuan pengrajin bordir. Pada kegiatan pelatihan, pelaku usaha diberikan pelatihan manajemen usaha yang mencakup manajemen modal, manajemen produksi dan pembuatan laporan keuangan. Usaha mitra diberikan pendampingan langsung dalam pengelolaan usahanya mulai dari membuat struktur organisasi usaha, membuat Standard Operational Procedure (SOP) kegiatan usaha serta membuat laporan keuangan usaha. Output yang dihasilkan dari kegiatan ini adalah terbentuknya struktur organisasi usaha bordir mitra yang mana setiap anggota sadah memiliki tugas masing-masing. Pelatihan juga menghasilkan Standard Operational Procedure (SOP) pada setiap kegiatan usaha bordir mulai dari SOP pemesanan, produksi dan pengiriman atau penjualan. Selain itu, usaha mitra juga sudah memiliki laporan keuangan sederhana usaha. Dengan demikian, pelatihan ini telah meningkatkan kemampuan usaha mitra dalam mengelola usaha sehingga pengelolaan usaha menjadi lebih teratur dan terarah. Hal ini tentu memberikan kemudahan kepada pengelola usaha untuk mengelola bisnisnya sehingga mencapai efisiensi dalam produksi. Pengelolaan usaha yang baik juga akan memberikan kemudahan dalam pengembangan usaha kedepannya.
Toksik organik kirleticilerin mekanokimyasal parçalanması
Authors: Pelitli Volkan
Published: July 2024

Günümüzde birçoğu termal ve termal olmayan bertaraf teknolojilerine ilişkin bazı yaklaşım ve yöntemler, toksik organik kirleticilerin parçalanması amacıyla önerilmektedir. Ancak hem yakma teknolojileri hem de diğer yüksek sıcaklığa sahip bertaraf teknolojileri, yetersiz yönetimlerin sebep olabileceği ikincil kirlenmeler ve sıcaklığın sabit tutulması için işletimi oldukça pahalı olan fazla miktarda enerji ve ortam gereksinimi nedeniyle uzun süre kullanıma uygun değildir. Öte yandan, biyoremediasyon ve fitoremediasyon da dahil olmak üzere farklı bertaraf teknolojileri ise, bitki ve mikrobiyal aktivitelerin kullanımıyla ilişkili dezavantaj ve kısıtlamalara sahiptir. Bu bağlamda, organik kirleticilerin zararlı etkilerini azaltmak veya ortadan kaldırmak için alternatif teknolojilere ihtiyaç duyulmaktadır. Son yıllarda yapılan araştırmalar, mekanokimyasal parçalanmanın organik kirleticileri parçalayarak çevreci yaklaşımla solvent kullanılmaksızın çevresel problemleri ortadan kaldıran yüksek potansiyele sahip yenilikçi bir teknoloji olduğunu göstermiştir. Bu teknoloji saha ölçeğinde çok çeşitli kirleticilere uygulanabilmektedir. Bu nedenle bu derlemede, (i) toksik organik kirleticilerin parçalanması için mekanokimyasal parçalanmanın etkinliği, kabul edilebilirliği, kullanılabilirliği ve güvenilebilirliğinin araştırılması amaçlanmıştır. Sonuç olarak, bu derleme atık yönetiminde mekanokimya uygulamaları ve ilgili mekanizmalar hakkında yol gösterici bir kaynak olacaktır.
Use of oriental spruce gum (Picea orientalis (L.) Link) in gluten-free milk-based dessert
Authors: Delikanlı Kıyak Berrak , Özcan Tülay
Published: July 2024

In this research, the usability of oriental spruce gum (Picea orientalis (L.) Link) as a texture improver in the production of gluten-free milk-based pudding was investigated. The produced custards were investigated in terms of color, texture, and sensorial properties. As a result, it was detected that oriental spruce gum usage in production of milk-based custard was not liked due to sensorial acceptability despite the development of the technological properties of the product in terms of physical and chemical properties. Moreover, it was detected that the product’s attractiveness in terms of taste and visual is less than the control sample. However, the use of the addition of subye in production in innovation studies can contribute to increasing awareness in the literature and providing product diversity, especially for celiac patients.
A study on two fourth-order fuzzy problems with fuzzy coefficients
Authors: Gültekin Çitil Hülya
Published: July 2024

This study is on the solutions of two fourth-order fuzzy problems with positive and negative fuzzy number coefficients. The solutions are found using the fuzzy Laplace transform method. Main results are given. Two examples are solved to illustrate the problems. Graphics of the found solutions are drawn for alpha level sets. Also, the graphics are interpreted and conclusions are given.
Analytical solution of the (2+1)-dimensional Zoomeron equation by rational sine-Gordon Method
Authors: Kemaloğlu Beyhan , Yel Gülnur , Bulut Hasan
Published: July 2024

The current study is about the solution of the Zoomeron equation, one of the important models of mathematics and physics. In this study, the rational Sine-Gordon expansion method (RSGEM) is used to obtain various analytical solutions of the model. Compared to other methods, this method is quite effective and the desired results were obtained. Although there are many analytical solutions to the model used in the literature, we present rational type solutions for the first time with this method. We obtained rational hyperbolic function solutions, and also classified all soliton solutions (kink-like, kink, singular kink, anti-kink, dark, bright). In addition, geometric representations of the solutions in two-, and three-dimensional space and contour shape are made with the Mathematica software program.
Fizik tutum ölçeğinin Türkçe’ye uyarlanması
Authors: Korkmaz Nilay , Kırtak Ad Vahide Nilay
Published: July 2024

Bu araştırmanın amacı, Kaur ve Zhao (2017) tarafından geliştirilen Fizik Tutum Ölçeği’ni (Physics Attitude Scale) Türkçe’ye uyarlamak ve ölçeğin psikometrik özelliklerini incelemektir. Araştırmaya ortaöğretim düzeyindeki 5 farklı okulda okumakta olan ve Fizik dersini alan 332 lise öğrencisi katılmıştır. Ölçeğin dil eşdeğerliliğe sahip olduğu görüldükten sonra SPSS 26 ve LISREL 8.80 programları kullanılarak geçerlik ve güvenilirlik analizleri yapılmıştır. Güvenilirlik analizi sonucunda ölçeğin Cronbach Alpha katsayısının 0.84 olduğu belirlenmiştir. Yapılan doğrulayıcı faktör analizi sonuçları, ölçeğin Türkçe formunun orijinal beş faktörlü yapıyı doğruladığını göstermiştir; ayrıca, uyum iyiliği indekslerinden üçünün kabul edilebilir, üçünün ise mükemmel uyum gösterdiği tespit edilmiştir. Bu sonuçlar, uyarlanan ölçeğin lise öğrencilerinin fiziğe yönelik tutumlarını değerlendirmek için kullanılabilecek geçerli ve güvenilir bir ölçme aracı olduğunu göstermektedir.
Un pájaro para los nidos de libros del desierto saharaui

Authors: Fuentes González Antonio Daniel , Fuentes Schmitte Celia
Published: July 2024

En español peninsular tenemos un pajarillo llamado por lo general collalba, blanca o negra, que en español saharaui es conocido por bubisher, procedente del hasaní, lengua neoárabe, hablada en la RASD. Ese pájaro tiene un fuerte significado en la cultura del desierto. Conocido por su aguante, simboliza los buenos augurios, de modo que tiene un lugar de honor en la rica y larga tradición oral del pueblo saharaui, como legítimamente reivindica el poeta y escritor saharaui Mahmud Awah (2010). Los saharauis, entonces, diluyen esos etiquetados occcidentalistas donde los refugiados o, simplemente, los otros pueblos, están atrasados porque no tienen cultura sino costumbres. La tienen y muy robusta, como forma de oralidad cultural que aquí perdemos a pasos agigantados.
Not Just Small Adults: Considerations for Pediatric Chronic Kidney Disease
Authors: Gerber Anisha , Kamath Nivedita
Published: July 2024

Chronic kidney disease (CKD), including pediatric CKD, is a global public health concern. Pediatric CKD has lasting effects into adulthood. In this review, we focus on the etiology of pediatric CKD and unique aspects that should be considered in treating a child with CKD, such as ensuring adequate nutrition and assessing growth hormone axis dysregulation. We review risk factors for CKD progression and how clinical surveillance can be used to address modifiable factors. We address the issues of accurate glomerular filtration rate (GFR) estimation, cardiovascular disease, immunization, neurodevelopment, and planned transition to adult care. We also cover kidney failure preparation and global CKD care disparities affecting children worldwide.
Granulomatosis with polyangiitis masquerading as disseminated tuberculosis in presence of bilateral lung cavities and hemorrhagic infarct
Authors: Patil Shital , Tak Sanidhaya
Published: July 2024

Lung cavitations with constitutional symptoms are usually associated with pulmonary tuberculosis due to its high prevalence and are the most common infectious cause in India. Granulomatosis with polyangiitis (GPA) with the systemic pulmonary disease will have different radiological presentations such as nodule, mass, and consolidation with or without cavitation. In this case report, we have reported a 40-year-old female presented with cough, fever, and weight loss of 6 months duration with chest imaging suggestive of bilateral cavitary lung disease. She was labeled as a case of disseminated tuberculosis due to involvement of the central nervous system and empirically treated with anti-tuberculosis treatment (ATT) without microbiological evidence of tuberculosis in smear and cartridge-based nucleic acid amplification tests. The absence of clinical response and radiological worsening to empirical ATT gives a clue for an alternate diagnosis. Bronchoscopy workup documented Aspergillus colonization and vasculitis workup in the presence of cavitary lung disease documented abnormally raised proteinase 3 anti-neutrophil cytoplasmic antibodies titers. She was treated with a combination of systemic methylprednisolone and azathioprine with voriconazole. Her clinical response was observed in 4 weeks and radiological response with complete radiological clearance of pulmonary cavitations was documented after 6 months of treatment. We recommend prompt workup and ruling out GPA in all cases with pulmonary cavitations with negative microbiological workup and no empirical ATT should be given in the era of rapid microbiological tests with good sensitivity and specificity.
Traditional Yakut Society of the Late 16th – Early 17th Centuries: Social Structures and Power (Sources, Studies, Discussions)
Authors: Парфенова О.А.
Published: July 2024

В статье исследована проблема устройства традиционного якутского общества на переломном этапе истории в момент вхождения в состав Российского государства. Данная тема стала предметом изучения многих поколений историков, однако новацией автора является анализ потестарных институтов власти (лидер, клан, линидж) и характеристика их взаимодействий с точки зрения новых теорий кочевых социумов. Особое внимание уделено якутскому лидеру Тыгыну, его исторической роли и этапам изучения его потестарной деятельности. Цель исследования – попытка типологизации общественного устройства якутов конца XVI – начала XVII вв. с позиции цивилизационного подхода. В задачи исследования входят: выявление основных структурных единиц якутского общества изучаемого периода и анализ их взаимоотношений. Также методологически важным в этом ключе становится определение статуса и роли потестарного лидера. Методы исследования – историко-генетический, институциональный. В результате исследования дается оценка якутскому родовому строю как системе стратификаций кланов и линиджей. Подчеркиваются такие особенности социального развития, как распыленность проживания, невыраженность и неустойчивость родоплеменных структур. Данное положение определенным образом затрудняет типологизацию социального устройства, но, тем не менее, с новых позиций якутское общество изучаемого периода оценивается как переходное к вождеству. В свою очередь, в деятельности одного из племенных якутских лидеров Тыгына (племя кангаласцев) проявилась объединительная тенденция якутских кланов и линиджей в новую социальную структуру.
Prokopy Yavtysy’s Prose Mythopoetics: Convergence of Magical Ritualism and Soviet Ideologems
Authors: Елепова М.Ю.
Published: July 2024

Научная новизна исследования обусловлена выявлением в прозе П.А. Явтысого оригинальной контаминации форм древнего магизма как выражения национальной традиции и советских мировоззренческих идеологем. Цель работы заключается в осмыслении проблематики и поэтики повести «Схватка» и рассказа «Бубен» Явтысого в контексте этно- и мифопоэтики, методологии изучения Северного текста русской литературы. Задачи исследования состоят в выявлении функций мифопоэтической образности в прозе Явтысого, осмыслении формы воплощения революционных идей в движении сюжета повести «Схватка», этногенетических причин синкретизма магизма и советизма, характеристики особенностей ленинского неомифа. В статье рассматривается проблематика и поэтика прозаических сочинений П.А. Явтысого разных жанров – повести и рассказа в контексте контаминации фольклорной образности, мифопоэтической ритуалистики и советских идеологем. Произведения писателя рассматриваются в рамках методологии изучения Северного текста русской литературы как локального сверхтекста. Феномен мифа, основы мифопоэтики в указанных произведениях изучаются на базе фундаментальных теоретических исследований по фольклору и мифологии и конкретных научных работ, посвященных ненецкой национальной мифологии. Филологические методы исследования дополняются антропологическим, этнографическим и геопоэтическим подходами к рассмотрению различных аспектов художественного текста. В результате анализа повести «Схватка» и рассказа «Бубен» выявлено переплетение архаических верований и магических действий героев с революционными идеями строительства новой жизни. Доказано, что феномен шаманизма предстает в двойственном освещении – как отживший элемент уходящего под ударами советских преобразований старого мира и в то же время как мистическое явление, вмещающее в себя трансцендентальный опыт многих поколений. Установлено, что в повести намечаются черты советского неомифа, когда Ленин предстает как новый культурный герой, усвоивший функцию мифологического первопредка по созиданию новой общности людей. Сделан ргументированный вывод о том, что идейный синкретизм прозы писателя обусловил особенности ее поэтики: сочетание магических формул, заклинаний и других форм национального фольклора с советскими лозунгами и социологизаторскими штампами.
Adaptive system of feeding.
Authors: Пономарёв Н. , Кирнос И. , Дуборезов В.
Published: July 2024

Внедрение адаптивной системы кормления молочного скота позволяет реализовать генетический потенциал продуктивности коров и повысить рентабельность предприятий.

Introduction of an adaptive feeding system for dairy cattle allows realization of the genetic potential of cow productivity and increase farm profitability.
Lupine seeds: specifics of application.
Authors: Сорокин А. , Руцкая В. , Ляпченко В.
Published: July 2024

Ввод в комбикорм зерна люпина и продуктов его переработки положительно сказывается на продуктивности бройлеров и кур-несушек.

Addition of lupine grain and products of its processing in compound feed has a positive effect on broiler and layer productivity.
Recycling of Bulk Polyamide 6 by Dissolution- Precipitation in CaCl2-EtOH-H2O Mixtures
Authors: Goldhahn Ruben , Minor Ann-Joelle , Rihko-Struckmann Liisa , Ohl Siew-Wan , Pfeiffer Patricia , Ohl Claus-Dieter , Sundmacher Kai
Published: July 2024

Given the problems of virgin plastic production from fossil resources and the growing amount of plastic waste, a rapid transition towards a circular economy is pursued. For recycling, the separation of mixed plastics into pure fractions is of paramount importance to prevent downcycling. Here, experimental parameters for selective bulk dissolution of polyamide 6 (PA 6) filaments (1.75 mm diameter, 1 cm long) using CaCl2-EtOH-H2O mixtures (CEW) at 75 ◦C are investigated. They include the energy supply mode, dissolution time, CEW composition and the CEW:PA mass ratio. Energy supply with ultrasound instead of microwaves improved the yield of dissolved and recovered PA 6 after 5 hours from 31 to 52%. In total, the PA 6 yield after 3 hours of bulk dissolution could be increased from 18 to 69% by changing the energy supply mode from microwave to ultrasound and the H2O:EtOH molar ratio of CEW from 0.40 to 1.33 whilst maintaining an optimal CEW:PA mass ratio of 8.5. Additionally, master plot analysis suggests that dissolution by microwave energy supply follows a contracting cylinder model, while ultrasonic energy supply aligns with a 2D diffusion or third-order kinetic model. Microscopic observations suggest that, in the case of ultrasonic energy supply, oscillating bubbles on the particle surface enhance the dissolution rate of PA 6 filaments in CEW.
A proof-of-principle study for δ15N measurements of aqueous dissolved nitrate and nitrite with a modified LC-IRMS interface
Authors: Hesse Tobias , Niemann Felix , Khaliq Shaista , Köster Daniel , Enss Julian , Feld Christian , Nachev Milen , Kerpen Klaus , Jochmann Maik A. , Schmidt Torsten C.
Published: July 2024

The analysis of nitrogen isotopes in aqueous dissolved nitrate is an effective method for identifying pollution sources and offers the potential to study the nitrogen cycle. However, the measurement of nitrogen isotope signatures of nitrate still requires extensive sample preparation or derivatization. In this study, a modified commercially available liquid chromatography-isotope ratio mass spectrometer (LC-IRMS) interface is presented that enables automated measurement of δ15N signatures from nitrate by online reduction of nitrate in two consecutive steps. First, vanadium(III)-chloride is used as a reducing agent to convert NO3- to NxOy under acidic conditions. The mix of nitrogen oxides is then transferred into a stream of helium and reduced to nitrogen (N2) analysis gas via a hot copper reactor. Prior to the online conversion of aqueous nitrate into elemental nitrogen, the sample was chromatographically separated from potential matrix effects on a PGC column. Precision was achieved at a level below 1.4 ‰ by injecting 10 µL of 50 mg L-1 N, using five different nitrate standards and reference materials. These materials spanned a range of more than 180 ‰ in δ15N. To demonstrate the applicability of the method we measured water samples from an enrichment experiment, where isotopically enriched ammonium chloride was administered into a small river over the course of two weeks. In contrary to our expectation, the δ15N values of river nitrate showed values between +0.4 ± 0.4 ‰ and +4.1 ± 0.3 ‰, varying over a small range of 3.7 ‰. Our study showed that the measurement of nitrate nitrogen isotope signatures with a modified LC-IRMS system is possible, but that further modifications and improvements would be necessary for a robust and user-friendly instrument.
Phononic Modulation of Spin-Lattice Relaxation in Molecular Qubit Frameworks
Authors: Zhou Aimei , Li Denan , Tan Mingshu , Lv Yanpei , Pang Simin , Zhao Xinxing , Shi Zhifu , Zhang Jun , Jin Feng , Liu Shi , Sun Lei
Published: July 2024

The advancement of molecular quantum information science demands solid-state integration of molecular electron spin qubits. With highly ordered structures and rational designability, microporous framework materials offer ideal matrices to host qubits. They exhibit tunable phonon dispersion relations and spin distributions, enabling optimization of essential qubit properties including the spin-lattice relaxation time (T1) and decoherence time. In this study, through spin dynamic and vibrational spectroscopic characterizations of two radical-embedded framework materials, we show that hydrogen-bonded networks give rise to a low Debye temperature of acoustic phonons and generates sub-terahertz optical phonons, both of which facilitate spin-lattice relaxation. Whereas deuterating hydrogen-bonded networks reduces both phonon frequencies and T1, eliminating such flexible structural motifs in the structure raises phonon dispersions and improves the T1 by one to two orders of magnitude. The phononic tunability of spin-lattice relaxation in molecular qubit frameworks would facilitate the development of solid-state qubits operating at elevated temperatures.
Developing Chlorin/Arylaminoquinazoline Conjugates with Nanomolar Activity for Targeted Photodynamic Therapy: Design, Synthesis, SAR, and Biological Evaluation
Authors: Krylova Lubov V. , Otvagin Vasilii F. , Gribova Galina P. , Kuzmina Natalia S. , Fedotova Ekaterina A. , Zelepukin Ivan V. , Nyuchev Alexander V. , Balalaeva Irina V. , Fedorov Alexey Yu.
Published: July 2024

In this report, we developed novel chlorin/arylaminoquinazoline conjugates for targeted photodynamic therapy of cancer. The synthesized photosensitizers consisted of chlorin-e6 metallocomplexes (Zn, In, or Pd) conjugated with arylaminoquinazoline ligands with high affinity for EGFR receptors. Through the incorporation of cationic moieties, we successfully prepared water-soluble conjugated drugs suitable for intravenous administration. Comprehensive SAR studies were conducted to evaluate the influence of structural features on the photodynamic activity of these conjugates. Additionally, the selectivity and antitumor properties of the conjugates were investigated in EGFR-expressing A431 human tumor cell line in vitro. Among the tested molecules, the In-containing conjugate effectively inhibited tumor cell proliferation at nanomolar concentrations, a rare property for conventional photosensitizers. In in vivo experiments, the conjugates rapidly accumulated at the tumor site in nude mice bearing A431 xenograft tumors. Subsequent distribution analysis among different tissues was carried out using fluorescence imaging and elemental analysis. Finally, we demonstrated that the most promising In-containing conjugate was capable of inhibiting xenograft tumor growth in mice through combinational therapy.
IMPACT OF HUMAN DEVELOPMENT ON CO2 EMISSIONS IN VIETNAM
Authors: Minh Nguyen Hoang , Ly Do Khanh
Published: July 2024

This study aimed to examine how human development affects CO2 emissions in Vietnam from 1990 to 2020. By utilizing data from the World Bank and CountryEconomy.com, the research results indicate no causal relationship between human development and CO2 emissions in Vietnam. However, the study found that human development has a positive impact on reducing CO2 emissions and, therefore, that it positively affects environmental protection. The result of this study is explained by the fact that more people need to live and invest in a cleaner environment to improve their health and well-being. This study contributes to enhancing knowledge about the relationship between human development and CO2 emissions, which is significant for reducing environmental pollution in the future.
PHÁT TRIỂN DU LỊCH CHĂM SÓC SỨC KHỎE TẠI TỈNH THỪA THIÊN HUẾ: GÓC NHÌN TỪ KHÁCH DU LỊCH
Authors: Hà Đinh Thị Khánh , Hằng Đoàn Lê Diễm
Published: July 2024

Du lịch chăm sóc sức khỏe đã xuất hiện từ lâu và trong bối cảnh dịch bệnh đã trở thành một xu hướng mới của du lịch thế giới. Việt Nam nói chung và Thừa Thiên Huế nói riêng có rất nhiều tiềm năng nhưng chưa có sản phẩm dịch vụ cụ thể để phát triển du lịch chăm sóc sức khỏe. Dựa trên tổng quan lý thuyết, nghiên cứu tập trung xác định mức độ cần thiết của các dịch vụ/ hoạt động CSSK nên có ở Huế trên cơ sở 6 nhóm hoạt động chính về: (1) thể chất; (2) tâm trí và cơ thể; (3) tâm linh và kết nối bản thân; (4) cảm xúc cá nhân; (5) thiên nhiên và (6) xã hội. Sử dụng phương pháp điều tra bằng bảng hỏi với 200 khách du lịch có hiểu biết về chăm sóc sức khỏe, một số hoạt động được đánh giá ở mức độ cần thiết cao như: tham quan các cảnh quan thiên nhiên, đạp xe, đi bộ, dành thời gian trải nghiệm cùng gia đình/bạn bè, đọc sách, dành thời gian cho bản thân, tắm suối khoáng nóng… Đồng thời, kết quả cũng cho thấy sự khác biệt trong ý kiến đánh giá của các nhóm du khách theo một số đặc điểm nhân khẩu học. Từ đó, bài viết đề xuất 6 nhóm giải pháp về phát triển sản phẩm du lịch chăm sóc sức khỏe tại tỉnh Thừa Thiên Huế.
SỰ LÂY LAN RỦI RO GIỮA TỶ GIÁ ĐỒNG VIỆT NAM VỚI CÁC ĐỒNG TIỀN CHỦ CHỐT CHÂU Á TRƯỚC VÀ TRONG ĐẠI DỊCH COVID-19
Authors: Tân Lê Tô Minh , Tuấn Nguyễn Mạnh , Hoàn Phan Thanh
Published: July 2024

Nghiên cứu áp dụng khung phân tích phân rã phương sai sai số dự báo để khảo sát mức độ lây lan rủi ro tỷ giá giữa đồng tiền Việt Nam (VND) với các đồng tiền chủ chốt trong khu vực châu Á trước và trong đại dịch Covid-19. Kết quả nghiên cứu cho thấy: Một là, nhìn chung mức lây lan rủi ro giữa VND với các đồng tiền châu Á chủ chốt trong nghiên cứu ở mức khiêm tốn. Hai là, cường độ lây lan rủi ro không cố định mà có sự thay đổi theo thời gian, tăng đột biến khi Covid-19 trở thành đại dịch. Ba là, đồng VND là đồng tiền nhận ròng rủi ro, đặc biệt từ các đồng tiền mạnh như KRW, SGD hay JPY và trở nên dễ bị tổn thương hơn khi dịch bệnh xảy ra.
Comparative Evaluation and Correlation of Salivary Total Antioxidant Capacity with Dental Caries among Smokers and Tobacco Chewers in North Karnataka Region of Indian Sub Population - A Clinico Biochemical Study
Authors: R Halkai Kiran , Halkai Rahul , Kapse Jyothi
Published: July 2024

Background Tobacco chewing and smoking influence salivary antioxidant levels and therefore their effect on dental caries incidence needs to be evaluated. Objectives To correlate the effect of smoking and tobacco chewing on salivary pH and total antioxidant capacity TAC in individuals with and without dental caries in North Karnataka region of India.Methods About 180 male patients aged 20-60 years were chosen and allotted to three groups n60. Group 1 Non-smokers and chewers. Group 2 Only tobacco chewers and Group 3 Only smokers. Each group was further split into two subgroups n30 A with dental caries B without dental caries. Dental caries was assessed by WHO-recommended DMFT Decayed Missing Filled Teeth criteria and salivary samples were obtained by spitting method. Salivary pH was determined and supernatants from centrifuged samples were subjected to ferric reducing antioxidant power FRAP assay for estimating TAC levels. The one-way analysis of variance ANOVA and Post Hoc Tukey tests were used for statistical analysis P lt0.05.Results Higher caries rate with lower pH and decreased salivary TAC levels were found in tobacco chewers and smokers with and without dental caries compared to non-tobacco chewers and non-smokers with significant difference.Conclusion Tobacco chewers and smokers showed decreased salivary TAC levels with lower pH and high caries rate compared to individuals without these habits.
In Vitro Evaluation of Mercury Release from Dental Amalgam After Magnetic Resonance Imaging
Authors: Raghavan Shubhasini , Mandal Bashishta , Birur Praveen , Karale Rupali , Bhaskar MV , K Jain Vipin
Published: July 2024

Background Dental amalgam is a widely used restorative material that is prepared by triturating mercury with a metal alloy. Mercury vapor is released during placement and removal of the restoration. It is also released during chewing and brushing. A few studies have reported that mercury is also released on exposure to MRI.Objectives This was an in vitro cross-sectional study. In this study we aimed to evaluate mercury release from dental amalgam after exposure to magnetic resonance imaging MRI.Methods Seven blocks of amalgam measuring about 5times5times5 mm were prepared. Each block was placed in 20 mL of artificial saliva for 48 hours and mercury analysis was performed using Inductive coupled plasma mass spectrometry before and after exposure to MRI. Students lsquotrsquo test was used for statistical analysis.Results Mean mercury levels before and after exposure to MRI were 4.74 ppb and 8.68 ppb respectively. Thus there was a significant increase in release of mercury after MRI. Conclusion It can be concluded that it is advisable to use non-mercury containing restorative materials in dentistry.
Formulation and Evaluation of Trimetazidine Hydrochloride Loaded Solid Lipid Nanoparticles
Authors: Manjunath K , Gowda S J Rohith , S Harshith
Published: July 2024

Objective The aim of the current study was to design trimetazidine hydrochloride solid lipid nano-particles SLNs and to evaluate them.Methods Hot homogenization technique was used for preparation of trimetazidine hydrochloride SLNs using different lipids Tristearin GMS and Compritol soy lecithin as stabilizers and Tween 80 Poloxamer as surfactants. Results The nano-particles were characterized for particle size polydispersity index PDI zeta potential entrapment efficiency and drug release patterns. Particle sizes ranged from 145.6 to 780.1 nm. All formulations showed PDI from 0.170 to 0.358. The zeta potential ranged from -24.2 to -38.0 mV trimetazidine SLNs demonstrated entrapment efficiency ranging from 84.42 to 93.82. The cumulative percentage release of drug from different trimetazidine hydrochloride nano- particles ranged from 75.43 to 93.59 depending upon nature and quantity of lipid used. Conclusion Among all the formulations F1 showed highest drug release of 93.59 and was considered as optimized formulation. Drug release was found to follow first order diffusion control and the lsquonrsquo value obtained from the Korsmeyer Pepparsquos model indicated anomalous diffusion non-Fickian type n value of F1 was 0.5716 as release mechanism. The particle size PDI and zeta potential of optimized formulation were found to be 153.8 nm 0.358 -38.0 mV respectively.
Hypothyroidism and Mental and Emotional Health of Females Aged 30-45 Years in Belagavi - An Exploratory Observational Study
Authors: M Ansari Fauzia , Agarwal Nuti
Published: July 2024

Background The rising incidence of thyroid dysfunction especially among middle-aged females necessitates a comprehensive understanding of the mental and emotional challenges they face.Objectives To assess the mental and emotional health of females aged 30-45 with hypothyroidism identify factors that may predispose them to thyroid dysfunction and explore its psychological impact including effects on physical appearance self-esteem and reproductive health.Methods A pilot study was undertaken to screen females for hypothyroid dysfunction using Zulewskirsquos clinical score inclusive of school and college teachers at A.M Shaikh Group of Institutions and other females around Nehru Nagar Belagavi visiting AMSC OPDs. As per the scale the subjects scoring above 5 were considered clinically to have hypothyroid dysfunction.Results Out of 111 females in the age range of 30-45 years who were provided with Zulewskirsquos rating scale 61 females scored between 0-2 32 scored between 3-5 and 18 scored above 6. This showed that 55 were Euthyroid 29 had subclinical hypothyroidism and 16 had clinical hypothyroidism. Fifty subjects who were found to have clinical subclinical hypothyroid dysfunction on the rating scale were provided with self designed open-ended questionnaire in order to elicit presence of mental and emotional difficulties.Conclusion The study aimed to identify common circumstantial factors contributing to thyroid dysfunction in this demographic and explored the psychological impact of thyroid dysfunction. It underscores the significance of early thyroid function screening to enhance patient care and treatment. Additionally the study examined the mental and emotional difficulties faced by females in multitasking roles and their potential link to thyroid dysfunction. The research offered suggestions for managing these challenges and promoting thyroid health
IMPACT OF LEGUMES AND CEREALS ON OLIVE PRODUCTIVITY IN THE SOUTH MEDITERRANEAN
Authors: Amassaghrou Asmae , Barkaoui Karim , Bouaziz Ahmed , Alaoui Si Bennasseur , Razouk Rachid , Daoui Khalid
Published: July 2024

Intercropping of trees with crops on the same piece of land at a given time has been hypothesized to: enhance crop yield, increase land-use and improve land equivalent ratio (LER). To address this hypothesis, we evaluated two legumes faba bean, lentil and three cereals durum wheat, soft wheat and barley grown in olive (Olea europea) agroforestry during two growing seasons (Y) with contrasting weather (Y1: 2015-2016 and Y2: 2016-2017) under a Mediterranean climate of north western Morocco. We assessed the effect of annual crops on olive growth and yield; the effect of trees on annual crop growth, yield components, and final yields; finally, we calculated the land equivalent ratio (LER) of olive agroforestry to assess the productivity of the associations. Legumes had no effect on olive growth and yield, while cereals negatively affected shoot elongation and olive yield compared to olive in sole crop. Olive limited crop growth and yield of all associated crops and yield reduction was around 33 % for legumes and 47 % for cereals in agroforestry than sole crop. The magnitude of reduction was higher in Y1 than Y2. Similar responses were found when comparing crops at different distances from trees. Annual crops generally had lower biomass and yield, near the trees compared to the middle of tree inter-rows, causing significant spatial heterogeneity in crops. The LER reached 1.36 with lentil and 1.33 with faba bean, the lowest LER was recorded with durum wheat in both years with 1.01 in Y1 and 1.02 in Y2, and the highest LER with cereals was registered with soft wheat and reached 1.19 in Y1.
IMPACT OF CLIMATE CHANGE ON SUGARCANE PRODUCTION IN UTTAR PRADESH, INDIA: A DISTRICT LEVEL STUDY USING STATISTICAL ANALYSIS AND GIS MAPPING
Authors: Sengupta Anirup , Thangavel Mohanasundari
Published: July 2024

Sugarcane is a cash crop typically cultivated for sugar. Due to climate change, there is a rise in temperature, disruption in the rainfall patterns and cycle of seasons. Such changes in weather parameters affect sugarcane production as well as sugar recovery from the canes. The study was conducted in Uttar Pradesh, India using GIS (Geographic Information System) based models and statistical multiple linear regression from districtwise data on yield and climatic parameters over the study period (1986 to 2015). The GIS models reveal that climatic factors like rainfall, temperature and evapotranspiration changed significantly throughout the study.The multiple linear regression model shows that such changes in climatic parameters have a significant impact on the yield of sugarcane. Graphical analysis of yearly data on temperature and sugar recovery (%) showed that temperature affects the amount of sugar recovered from the canes. The study aims to illustrate the evidence of climate change and its impact on sugarcane production in Uttar Pradesh.
MOLECULAR ISOLATION, SCREENING AND IDENTIFICATION OF HYDROCARBON DEGRADING FUNGI FROM OIL CONTAMINATED SOILS, KRI, IRAQ
Authors: Abdulrahim Ahmed Tablo , Ganjo Ahmed Dilshad
Published: July 2024

This study aims to isolate and recognize (native/indigenous) hydrocarbon degrading fungal strains from oil-laden soils, at different geographical locations in KRI oilfields, Iraq. The identification was mainly based on macroscopic and microscopic examinations, but due to morphological similarities, which make the identification at species level doubtful in some cases, an attempt was made to use molecular techniques as well, as confirmatory/comparative analysis. The extracted DNA from hypha was used for polymerase chain reaction (PCR) amplification, using specific internal transcribed spacer primer (ITS1/ITS2). PCR product sequencing analyses were compared with the other related sequences in GenBank (NCBI) for molecular evolutionary analyses. Results showed that; out of 68 screened fungal strains; only two genera (i.e. Aspergillus spp. and Penicillium sp.) were identified as the most potent hydrocarbon degrading fungi. DNA sequence analysis confirmed the validity of the species as; Aspergillus fumigatus-KU321562.1; A. flavus-MH270609.1; A. niger-MK452260.1 and Penicillium chrysogenum-MK696383.1.