bluuebunny/crossref_metadata_2025 huggingface dataset:
A Validated Liquid Chromatographic Method for the Estimation of Imatinib Mesylate in Dosage Forms: Application to Chemometrics based Robustness Testing and Greenness Assessment
Authors: Panda S.S. , Mohanty S.K. , Pulusu V.S. , Sahu S. , Das B.
Published: July 2023

An eco-friendly liquid chromatography method was developed for determining imatinib mesylate in pharmaceuticals. During pre-development studies, Using a greener mobile phase and a combination of qualitative and semi-quantitative green metrics techniques, the environmental sustainability of the procedure was maintained. Methanol:water (pH maintained at 3.5 using orthophosphoric acid) at 75:25%, v/v flowing at 1 mL/min was the final mobile phase used on a C-18 column. The diode array detector detected imatinib at 262 nm. Method specificity, accuracy, precision, selectivity and system suitability were tested over a linear concentration range of 5-120 μg/mL of imatinib. The limit of detection and limit of quantitation values were 1.5 and 5.0 μg/mL, respectively. In addition, the factorial design showed the procedure to be reliable with minimum testing. Finally, the method recovered the maximum (> 99%) of the analyte from the dosage form. Overall, the present method is suitable for routine applications in quality control of dosage forms of imatinib.
Synthesis and Characterization of Ru(III) Complexes Containing Quinazoline Derivatives and their Biological and Catalytic Activities
Authors: Bhattacharjee Rita , Gayathri Virupaiah
Published: July 2023

Ruthenium trichloride trihydrate (RuCl3·3H2O) reacted with quinazoline derivative ligands (L) in 1:1 mole ratio in acetone to yield a series of brown/green/greenish black ruthenium(III) complexes of the type RuX3L·nH2O where X = Cl, n = 0, 1, 2 and 3 and L is 6-R-5,6-dihydrobenzoimidazo[1,2-c]quinazoline (R = ethyl: L1/n or i-propyl: L2, L3/n or i-butyl: L4, L5/phenyl: L6/furyl: L7/thiophenyl: L8/o or p-hydroxyphenyl: L9, L10/o or p-chlorophenyl: L11, L12/dimethylaminophenyl: L13). All the synthesized Ru(III) complexes were characterized by elemental analyses, conductivity measurements, infrared, electronic, ESR and mass spectral techniques, TGA, magnetic susceptibility and electrochemical studies. A square pyramidal geometry around the metal ion was proposed for all the complexes. The biological activities of the ligand and its ruthenium(III) complexes have been studied on microorganisms such as B. subtilis, E. coli and yeast by cup-plate method. The catalytic activity of the synthesized ruthenium(III) complexes towards oxidation of benzyl alcohol, cyclohexanol and hydroquinone was also carried out in acetonitrile with tert.-butyl hydroperoxide (t-BuOOH) as co-oxidant.
Exploration of in vitro Antioxidant and Cytotoxic Activities of Whole Plant Extracts of Rhynchosia heynei Wight & Arn: An Endemic Medicinal Herbaceous Under Shrub of Eastern Ghats of India
Authors: Korukola Nirmala , Vedula Girija Sastry , Bonthu Mohan Gandhi , Atmakuri Lakshmana Rao
Published: July 2023

This study reports the antioxidant and anticancer potential of Rhynchosia heynei, a widely used plant in traditional medicine, against various cancerous cell lines. The study found that R. heynei exhibited significant radical scavenging activity, indicating its potential as a natural antioxidant compound to guard against oxidative stress-induced diseases, including cancer. The plant extracts also displayed selective cytotoxicity towards various cell lines, with the most potent cytotoxicity exhibited by the ethanol extract towards the MCF-7 cell line and diethyl ether extract towards the HCT-116 cell line. The hexane extract exhibited substantial cytotoxic activity against HepG2, HCT-116 and L6 cell lines. However, the aqueous extract of R. heynei was the least cytotoxic of all the cell lines employed. Overall, the cytotoxic activity of R. heynei extracts was majorly selective towards MCF-7 and HCT-116. The findings suggest that R. heynei could be a potent natural product for developing anticancer drugs with fewer side effects. Further, in vitro and in vivo studies are required to determine the exact mechanism of action of the plant’s potential anticancer activity.
Long Washout Periods Between Biologics for Inflammatory Bowel Disease Clinical Trials Are Unnecessary: A Canadian Retrospective Cohort Study
Authors: Vuyyuru Sudheer K. , Archer Meagan , Nguyen Tran M. , Beaton Melanie , Jairath Vipul
Published: July 2023

INTRODUCTION:

To assess the safety of early vs late biologic switch in patients with inflammatory bowel disease.

METHODS:

In this retrospective study, we included patients with inflammatory bowel disease who underwent biologic switch between January 2014 and July 2022 at a tertiary center. The primary outcome was any infection by 6 months.

RESULTS:

There was no statistically significant difference between patients who had early biologic switch (≤30 days, n = 51) and late switch (>30 days, n = 77) in either infectious or noninfectious adverse events by 6 and 12 months.

DISCUSSION:

Early biologic switch is safe. A prolonged washout period between 2 biologics is unnecessary.
Acute Appendicitis as the First and the Only Presentation of Systemic Mastocytosis
Authors: Sarwate Mrinal , Bakhshwin Ahmed
Published: July 2023

Systemic mastocytosis is a rare myeloproliferative disorder characterized by abnormal accumulation of mast cells in a variety of organs. When affecting the gastrointestinal tracts, it may manifest with steatorrhea, malabsorption, hepatomegaly, splenomegaly, portal hypertension, and ascites, among others. To our knowledge, only one case of systemic mastocytosis has been reported affecting the appendix. We present another case of a 47-year-old woman who was admitted for right-sided acute abdominal pain and found to have systemic mastocytosis in her appendectomy specimen as the first and only manifestation of her disease.
Zur Situation der Aussiedler in der Bundesrepublik Deutschland
Authors: Mammey Ulrich
Published: July 2023

Dieser Bericht kann nur in knapper Form die Schwierigkeiten der Konzeptualisierung und Durchführung einer auch in siedlungsstruktureller Hinsicht repräsentativen Panelbefragung unter Aussiedlern schildern sowie die vorläufigen Ergebnisse der ersten Grobauswertung der ersten Befragungsrunde vor stellen. In 1 219 Aussiedlerhaus halten der Zuzugsjahre 1989 bis 1991 wurden insgesamt 1 962 Personen, die zum Befragungszeitpunkt während des ersten Quartals 1991 noch überwiegend in Übergangswohnheimen untergebracht waren, zu den Wanderungsgründen, zur persönlichen undfamilialen Situation in den Herkunftsländern Polen, Sowjetunion und Rumänien sowie zu ihren Zukunftserwartungen in Deutschland befragt.Zwischen den Haushaltsvorständen aus den drei Herkunftsländern sind deutliche Unterschiede hinsichtlich der demographischen Strukturen, der Gründe für die Aussiedlung, der Sprachkenntnisse sowie der regionalen Verteilung in Deutschland erkennbar. Da es sich bei Aussiedlern, die erst kurze Zeit im Bundesgebiet leben, um eine geographisch hochmobile Bevölkerungsgruppe handelt, ist mit einer Fortdauer des räumlichen Segregationsprozesses zu rechnen. Zu diesen Fragen, wie auch zu denen nach dem Integrationsverlauf während der ersten Jahre in Deutschland, wird die zweite Befragungsrunde im Frühjahr 1994 Antwort geben.
Groundwater Potential Zone Delineation Using Multi-criteria Decision-making Approach: A Case Study
Authors:   Mepco Schlenk Engineering College, Rajaveni S.P. , Muniappan N.
Published: July 2023

Over-exploitation of groundwater from coastal aquifers causes seawater intrusion and depletion of freshwater resources. As 40 percent of the world’s population live within 100 km of the coast. This will increase the demand for potable water in coastal aquifers. Hence, it is essential to evaluate the sources of fresh-groundwater potential and productivity in coastal aquifers. Nowadays, integrated studies based on geographic-information systems play a major role in groundwater-exploration studies. Thus, the current study was carried out with the objective to delineate groundwater potential in the Nambiyar river basin in Tamil Nadu's southeast coastal area, where groundwater is in a critical condition. In order to improve groundwater recharge, it is very important to identify possible recharge areas. A novel work of the integration of remote sensing, geographic information system (GIS) and multi-criteria decision-making approaches of analytical hierarchical-process methodologies (AHP) was used in the present study. A total of 11 thematic layers, such as slope, curvature, soil, roughness, topographic-wetness index, drainage density, land use/land cover, geology, geomorphology, lineament density and rainfall, were generated for delineating groundwater potential zones. All the thematic maps are weighted using AHP based on the attributes of the classes and the potential capacity of their water supply. The demarked region of groundwater potential was validated by comparing pre-monsoon and post-monsoon groundwater levels. The groundwater potential zone map was classified into five categories: very high, high, moderate, low and very low. Areas with very high and very low potentials are delineated only in very limited areas. 64% of the regions are covered under the moderate-potential zones. The low-and high-groundwater potential zones are delineated at 22% and 14%, respectively. KEYWORDS: GIS, Recharge areas, Groundwater potential, Nambiyar river basin, AHP
Economic and Time Risk Factors Influencing the Construction Projects: A Case Study of Lebanese Construction Projects
Authors:   Near East University, Ahmad Omar , Nouban Fatemeh
Published: July 2023

In recent years, Lebanon has been grappling with a multitude of crises across all sectors, presenting numerous challenges that have hindered the progress of the construction industry. The construction industry in Lebanon is plagued by a complex array of risks that can lead to the downfall of construction projects. Therefore, this study is primarily concerned with identifying the most crucial economic and time risk factors influencing the Lebanese construction projects. To achieve the research aim, a questionnaire was initially developed from a review of various sources of literature and then refined to reflect the unique circumstances faced by Lebanon in recent years. In addition to that, some interviews to analyze the economic and time risk factors were conducted among expert respondents in the Lebanese construction industry. Then, the relative important index (RII) was applied in order to classify the major risk factors. The findings obtained from the study reveal that currency fluctuation, risk of war, geological risks, risk of pandemics and vendor failures are the most crucial risk factors that influence the time and cost of the Lebanese construction projects. Finally, in order to mitigate the occurrence of the most critical risk factors identified in this study and ensure successful construction projects in Lebanon, effective risk-management strategies should be implemented. KEYWORDS: Risk factors, Construction projects, Cost, Time, Lebanon.
Factors Affecting Maintenance Practises in Iraq’s Hospital Buildings
Authors:   University of Baghdad, M. Kadhim Esraa , R. Altaie Meervat
Published: July 2023

A lack of adequate building maintenance is a significant obstacle faced by governmental hospitals. This paper evaluates factors that negatively impact building-maintenance practices in Iraq. A literature review was conducted to identify factors affecting maintenance. A list of 42 factors affecting hospital-buildings was collected from previous studies and tested using a structured questionnaire distributed to hospital-maintenance experts. During the data analysis, 76 valid questionnaires were used. Based on the respondents’ ratings, the relative-importance index (RII) was used to determine the level of importance of each factor. From the results, it was concluded that twelve factors affect maintenance practices in hospital buildings: faulty design (0.889), lack of funding (0.874), inadequate training (0.871), misuse of building facilities (0.866), construction errors (0.863), lack of work experience (0.858), building age (0.826), individual modifications carried out by the hospital staff (0.826), shortage of maintenance staff (0.824), administrative corruption (0.821), selection of unqualified maintenance contractors (0.816) and unavailability of skilled appointed maintenance personnel (0.808). Understanding these factors’ effects is essential for maintenance-department managers to develop strategies for maintaining hospital buildings in Iraq by controlling them, as well as identifying problems and finding appropriate solutions to avoid them. KEYWORDS: Governmental hospitals, Maintenance, Iraq, Building maintenance, Maintenance practices, Factors affecting maintenance
Bioremediation of Oil-contaminated Sand
Authors:   Government College of Technology, Sathyapriya S. , Sharvesh R. , Natarajan C.
Published: July 2023

The energy demand is set to grow very rapidly and the potential demand for oil around the world is at its highest level. Apart from indigenous oil sources, crude oil is imported by water transportation to fulfill local demand. The occurrence of oil leakage during drilling and transportation in pipelines is a major concern. As a result of this, soil is getting polluted and its geotechnical properties are altered. In this study, the effect of engine oil and diesel contamination on the geotechnical parameters of sea sand has been studied. Further, to enhance the properties of oil-contaminated sand, the bioremediation method was adopted. Sea sand from Ganagalla Peta beach, Andhra Pradesh state, India was taken up for the study. In the laboratory, 4%, 8%, 12% and 16% of engine oil and diesel were used to artificially contaminate the sea sand and geotechnical parameters; namely, compaction, shear strength and permeability, were studied for oil-contaminated sand and compared with those of virgin sea sand. In the next stage, bioremediation of engine oil-and diesel-contaminated sand was carried out to improve the geotechnical properties. It has been found that the geotechnical properties had improved after three days of bioremediation. Fourier transform infrared spectroscopy (FTIR) analysis showed that the contaminated sand is of a lipopeptide nature and showed the presence of carboxyl groups, whereas the IR absorption pattern of the treated sand matches with N-Methyl-N-Vinyl Acetamide. KEYWORDS: Engine-oil contamination, Diesel contamination, Bioremediation, Bacillus subtilis, Geotechnical properties, Compaction characteristics, Shear-strength characteristics, Permeability, FTIR analysis.
Tension-Stiffening of Reinforced HVFA-SCC Beams
Authors:   Universitas Sebelas Maret, Fajrul Falah Muhammad , Adi Kristiawan Stefanus , Alfisa Saifullah Halwan
Published: July 2023

Prediction of cracking behavior and deformation of reinforced concrete is a complex problem, including reinforced concrete that can still bear tensile stress after cracking due to the bond between reinforcement and surrounding concrete, termed the tension-stiffening effect. This research aims to determine the tension-stiffening of reinforced High Volume Fly Ash Self-compacting Concrete (HVFA-SCC) at various tensile reinforcement ratios. In this tension-stiffening analysis, shrinkage and creep effects are taken away. The data used in the analysis was obtained from beams tested with two loading points. The tests were conducted on six reinforced HVFA-SCC beams and six Normal Concrete (NC) beams with dimensions of 150 x 250 x 2000 mm, with tensile reinforcement ratios of 0.61%, 1.10% and 1.55%. The analysis shows that the effect of creep on shrinkage is negligible, so that it can be ignored in the calculation. On the other hand, shrinkage increases the value of the maximum tension-stiffening stress by 1.43% and the ultimate tension-stiffening stress (𝜎𝑡𝑠,u) by 72.51% from the initial tension-stiffening values. The greater the tensile reinforcement ratio in concrete, the smaller the effect of tension-stiffening stress. KEYWORDS: Creep, HVFA-SCC, NC, RC beams, Shrinkage, Tension-stiffening.
Identification and Assessment of Major Risks in Syrian Construction Projects: Lattakia-Syria Case
Authors:   Tishreen University, Ghanem Kattoub Reem , Omran Jamal
Published: July 2023

The Syrian construction industry is plagued with risks that can be challenging to the overall success of any construction project. To minimize a project’s damage in terms of cost, time and quality, an authentic data-driven and expert-approved risk plan must be developed. This paper proposes a methodology to identify and assess major risks based on the personal evaluation of experienced civil engineers as a step in a comprehensive risk-management process. By combining a ranked risk magnitude index and an assigned risk zone, fifteen major risks were identified and assessed. Companies are advised to use the list to develop a resourceful general risk plan. Combining the two methods together makes the risk plan more representative and thus more reliable, as the two proposed methods can result in different rankings. The top fifteen risks in the Syrian construction industry were mainly management, financial and design risks. Locating in the zone of maximum risk came “an unprecedented increase in raw-material prices” and “the loss due to an increase in fuel prices” as number one and number two, respectively”. “Unavailability of resources” was next in the zone of high risk. “Improper cost estimation” and “losing critical work forces at a critical time” scored high in the final ranking. KEYWORDS: Risk identification, Risk assessment, Syria, Construction industry.
Regression Analysis for Predicting Soil Strength in Bangladesh
Authors:   Islamic University of Technology, Rahman Sabab Shadman , Md. Shahin Hossain , Muhim Bondhon Muftashin , Ehsan Kabir Md.
Published: July 2023

This study focuses on establishing a robust relationship between Standard Penetration Test-N values (SPT-N), geotechnical parameters and unconfined compressive strength (qu) using regression analysis. The proposed relationship offers a reliable method for estimating qu based on SPT-N values. A comprehensive dataset comprising approximately 200 soil samples collected from various boreholes across Dhaka city was utilized. Multiple Linear Regression (MLR), Rando-forest Regression (RFR) and AdaBoost Regression techniques were employed to develop a unified correlation model. Evaluation metrics including R-squared (R2), Mean Absolute Error (MAE) and Root Mean Squared Error (RMSE), along with Trend-behavior Analysis were employed to assess and compare the performances of the models. Additionally, sensitivity analysis was carried out on the selected model in order to assess the importance of each parameter used to predict qu. Finally, the selected model was compared against the existing empirical models that were published in previous studies. In terms of evaluation metrics and Trend-behavior Analysis, the results showed that the RFR model performed better than the others. Additionally, the selected model outperformed the others, demonstrating the highest R2 score, the smallest RMSE and MAE values and lower residuals compared to the previous models. Hence, the proposed model provides accurate predictions of qu for clayey soil in Bangladesh. Its implementation could ensure more efficient geotechnical designs, specifically adjusted to the geological conditions of the Dhaka region. While previous studies have established regional equations for various parts of the world, our model uniquely has incorporated the Plasticity Index (PI) as a predictor for qu and is specifically calibrated for the geological characteristics of Dhaka city. The findings of this study highlight the effectiveness and applicability of regression analysis in predicting qu for Dhaka's soil properties, thus introducing a valuable tool for enhancing the accuracy and effectiveness of geotechnical assessments and design in the region. KEYWORDS: Unconfined compressive strength, Standard penetration test-N values, Plasticity index, Multiple linear regression, Random-forest regression, AdaBoost regression, Evaluation metrics, Trend-behavior analysis, Sensitivity analysis
Эволюция концепта скуки в творчестве Елены Шварц
Authors: Vorontsova Kristina
Published: July 2023

This paper focuses on the concept of boredom in the creative work of one of the significant figures of Soviet underground culture – Elena Shvarts. All the creative heritage – both poetic and prosaic – is treated like a semiotic unity, so that it is possible to see the evolution in understanding such a notion during more than five decades of the poet’s life. While analyzing the five-volume collection by Shvarts, statistical calculation has revealed only 28 cases of using the concept. Even though for Shvarts’s lyrical subjects, who are usually passionate and ecstatically active, boredom is not specific at all, the author sometimes puts this concept in the meaningful center of her creative universe. It could be done both explicably and implacably through the description of “boring” landscapes and events. After close reading of the texts from the five-volume collection, it is claimed that boredom in Shvarts’s oeuvre is strictly associated to the physical (and\or physiological) world, with its routines, wishes and activities. To the contrast, the transcendental world and everything connected to the sacrum, according to Elena Shvarts, cannot be boring.
Motyw nadziei w najnowszej poezji Dmitrija Strocewa
Authors: Osiewicz Bartosz
Published: July 2023

This article is devoted to the analysis of the motif of hope in the latest poetry of the Belarusian independent poet Dmitry Strotsev. The peaceful Belarusian revolution of 2020 became a source of inspiration for Strotsev and influenced the form and content of his latest works. The methodological basis of the research is focused on the observations on hope made by the French philosopher Gabriel Honoré Marcel in the essay Outline of the phenomenology and metaphysics of hope (1942), and by the priest Józef Tischner in the essay Binding of Hope (1973). In Strotsev’s latest poetry, the theme of hope is combined with the heroic peaceful struggle for freedom undertaken by Belarusian society and is inscribed in an intertextual dialogue with the Bible. The poet presents a collective portrait of people filled with hope, which is an impulse for them to act. It shows society at the time of a test of enslavement. The answer to enslavement is opposition born of hope. The experience of heroism also flows from hope. Strotsev’s works not only immortalize the people who fought for freedom, but also multiply the hope inherent in all those who take up a heroic fight against evil. Hope allows them to visualize the “fragility” and “impermanence” of evil. It is also a comfort to those who are suffering from loss. It also helps not to succumb to despair.
Existence of nonminimal solutions to an inhomogeneous elliptic equation with supercritical nonlinearity
Authors: Ishige Kazuhiro , Okabe Shinya , Sato Tokushi
Published: July 2023

In our previous paper [K. Ishige, S. Okabe, and T. Sato, A supercritical scalar field equation with a forcing term, J. Math. Pures Appl. 128 (2019), pp. 183–212], we proved the existence of a threshold

κ

∗

>
0

{\kappa }^{\ast }\gt 0

such that the elliptic problem for an inhomogeneous elliptic equation

−
Δ
u
+
u
=

u

p

+
κ
μ

-\Delta u+u={u}^{p}+\kappa \mu

in

R

N

{{\bf{R}}}^{N}

possesses a positive minimal solution decaying at the space infinity if and only if

0
<
κ
≤

κ

∗

0\lt \kappa \le {\kappa }^{\ast }

. Here,

N
≥
2

N\ge 2

,

μ

\mu

is a nontrivial nonnegative Radon measure in

R

N

{{\bf{R}}}^{N}

with a compact support, and

p
>
1

p\gt 1

is in the Joseph-Lundgren subcritical case. In this article, we prove the existence of nonminimal positive solutions to the elliptic problem. Our arguments are also applicable to inhomogeneous semilinear elliptic equations with exponential nonlinearity.
Cloning and expression analysis of VrNAC13 gene in mung bean
Authors: Zhang Siyu , Ai Jing , Guo Yaning , Bai Yu , Yao Han , Wang Fugang
Published: July 2023

To explore the role of NAC transcription factors in mung bean (Vigna ratiata), we here comprehensively analyzed VrNAC13 structure and expression patterns in the mung bean cultivar “Yulin No.1”. The nucleotide sequence of VrNAC13 (GenBank accession number xp014518431.1) was determined by cloning and sequencing the gene. A predicted transcriptional activation domain in VrNAC13 was validated with a yeast one-hybrid assay. The composition and functional characteristics of VrNAC13 were analyzed using basic bioinformatics techniques, and the expression characteristics of VrNAC13 were analyzed via quantitative reverse transcription-PCR. The results showed that VrNAC13 was 1,068 bp in length and encoded a product of 355 amino acids. VrNAC13 was predicted to contain a NAM domain and to belong to the NAC transcription factor family. The protein was hydrophilic and contained several threonine phosphorylation sites. Phylogenetic analysis showed that VrNAC13 was highly similar in sequence to two Arabidopsis thaliana NAC proteins; we hypothesize that VrNAC13 may perform functions in mung bean similar to those of the two closely related proteins in Arabidopsis. Promoter analysis of VrNAC13 revealed cis-acting elements predicted to respond to abscisic acid (ABA), gibberellin, auxin, light, drought, low temperature, and other stressors. VrNAC13 was most highly expressed in the leaves and expressed at very low levels in the stem and root. It was experimentally determined to be induced by drought and ABA. Based on these results, VrNAC13 appears to regulate stress resistance in mung bean.
Investigation of MXene-modified agar/polyurethane hydrogel elastomeric repair materials with tunable water absorption
Authors: Liu Jinbo , Tang Xuewei , Chen Xiaotong , Wang Guoqing
Published: July 2023

The study of repairing materials is of paramount importance, considering that damage during usage can significantly impact performance and bring inconvenience during maintenance work. One highly sought-after material is water-swellable elastomers, known for their effect in sealing and repairing damaged materials. In this study, agar/polyurethane dual-network hydrogel elastomers were prepared, which were further modified by MXene. The material exhibits a uniform and flat surface, along with a rich pore-filled internal structure. It showcases excellent thermal stability, good tensile strength retention, and a controllable low swelling rate (SR) upon water absorption. The performance of the material can be regulated by the MXene content. In addition, the “water absorption–drying–water absorption” cycle effectively controls the reduction of the SR and gradually increases the tensile strength. All samples demonstrated exceptional photothermal conversion efficiency, stability, and durability, with the maximum conversion temperature increasing with the MXene content. The scratch repair experiments demonstrated the remarkable potential of these materials for photothermal conversion-assisted repair. These materials can be adapted as auxiliary restoration materials in water bodies and various application environments, making them ideal for repair and restoration purposes.
Space use by Callosciurus erythraeus in a fragmented landscape
Authors: Guichón M. Laura , Benitez Verónica V. , Gozzi A. Cecilia , Doyle Santiago R. , Cassini Guillermo H.
Published: July 2023

Tree squirrel species that are successful invaders may modify their behaviour according to the characteristics of the invaded community. We studied the use of space by Callosciurus erythraeus in the main invasion focus established in Argentina, where suitable habitat is highly fragmented and immersed in a rural–urban landscape of the Pampas region. We evaluated habitat use in relation to the dominant arboreal vegetation (evergreen vs. deciduous) based on seasonal trapping data throughout two years and home range size and overlap based on seasonal radio-tracking data in two consecutive years. We captured 476 squirrels with a higher trapping success in areas dominated by evergreen vegetation. Effective home ranges were smaller for females (0.10–0.77 ha, n = 12) than for males (0.9–3.78 ha, n = 3). We observed home range overlap between and within both sexes, suggesting no or low territoriality. Our results support the two working hypotheses on the relatively higher use of areas dominated by evergreen vegetation and on the relatively small home range sizes and large overlapping areas associated to high squirrel density. The flexibility in the use of different type of arboreal patches would be another attribute linked to the invasion success of this species.
Potential protective effects of Huanglian Jiedu Decoction against COVID-19-associated acute kidney injury: A network-based pharmacological and molecular docking study
Authors: Wu Weichu , Zhang Yonghai , Liu Guoyuan , Chi Zepai , Zhang Aiping , Miao Shuying , Lin Chengchuang , Xu Qingchun , Zhang Yuanfeng
Published: July 2023

Corona virus disease 2019 (COVID-19) is prone to induce multiple organ damage. The kidney is one of the target organs of SARS-CoV-2, which is susceptible to inducing acute kidney injury (AKI). Huanglian Jiedu Decoction (HLJDD) is one of the recommended prescriptions for COVID-19 with severe complications. We used network pharmacology and molecular docking to explore the therapeutic and protective effects of HLJDD on COVID-19-associated AKI. Potential targets related to “HLJDD,” “COVID-19,” and “Acute Kidney Injury/Acute Renal Failure” were identified from several databases. A protein–protein interaction (PPI) network was constructed and screened the core targets according to the degree value. The target genes were then enriched using gene ontology and Kyoto Encyclopedia of Genes and Genomes. The bioactive components were docked with the core targets. A total of 65 active compounds, 85 common targets for diseases and drugs were obtained; PPI network analysis showed that the core protein mainly involved JUN, RELA, and AKT1; functional analysis showed that these target genes were mainly involved in lipid and atherosclerosis signaling pathway and IL-17 signal pathway. The results of molecular docking showed that JUN, RELA, and AKT1 had good binding activity with the effective chemical components of HLJDD. In conclusion, HLJDD can be used as a potential therapeutic drug for COVID-19-associated AKI.
Crack Initiation in Bulk Matrix of Austenitic Stainless Steel during Very High Cycle Fatigue
Authors: Chai Guocai , Bergström Jens , Burman Christer
Published: July 2023

In the very high cycle fatigue regime, fatigue crack initiation in high-strength steels is usually correlated to a subsurface inclusion with a fine granular area (FGA). Localized stress–strain concentration at the subsurface inclusion is a critical factor. Fatigue crack initiation with an FGA in the bulk matrix without any defect has rarely been reported. In this paper, a fundamental study on the formation of FGAs in the bulk matrix of an austenitic stainless steel has been carried out using a progressive stepwise load-increasing test with a cycle step of about 108 cycles. FGA formation in the subsurface bulk matrix has been observed. The microstructural damage in the fatigue-tested specimens has been studied using the electron channeling contrast imaging electron microscopy technique. Strain localization and grain fragmentation are the main processes for the formation of FGAs. Local plasticity exhaustion leads to crack initiation due to local stress concentrations. This method can also be used to predict the fatigue damage process, especially the damage rate in individual specimens.
O PROCESSO DE SIGNIFICAÇÃO DE CIDADÃO/CIDADANIA NO CONTEXTO DE REDEMOCRATIZAÇÃO
Authors: Fernandes Carolina , Dos Santos Matheus Rodrigues
Published: July 2023

Este estudo está vinculado aos pressupostos teórico-metodológicos da Análise de Discurso Materialista, teoria que nos permite compreender a produção de sentidos em seu funcionamento ideológico e político. Neste artigo, buscamos analisar como a concepção de “cidadão” e “cidadania” se constitui a partir do processo de redemocratização do Estado brasileiro, a fim de construir um imaginário social para o cidadão enquanto um sujeito de direito em uma nação democrática. Para tanto, analisamos sequências discursivas da Constituição Federal de 1988 e da Lei de Diretrizes e Bases de 1996 a fim de observar os movimentos de sentidos para compreender os processos de significação para o cidadão brasileiro e sua educação. A partir da análise realizada, esta pesquisa nos possibilitou compreender que os sentidos se produzem na imbricação entre duas formações discursivas, configurando-se em distintas posições-sujeito que dividem o sujeito-cidadão entre o individual e o social.
THE CURIOSITY OF THINGS, OBJECTS, AND SUBJECTS IN MARK HADDON’S NOVEL OF INCIDENTS
Authors: Sá Luiz Fernando Ferreira
Published: July 2023

I begin with a moment from Mark Haddon’s The Curious Incident of the Dog in the Night-time (2003) describing an encounter with things, in the form of an enumeration and a collection of sorts, where bodily, sensory, mental, and imaginative life are fused. Probing the porous boundaries, affinities, and frictions between contemporary subjects and objects, between bodies, special minds, and things, this essay develops novel approaches to notions of materiality, the object world, and embodied experience while also interrogating developments in the area of material culture, object studies, cultural phenomenology, and thing theory. Haddon and Boone insisted on the material basis of all aspects of human existence and finally suggested that the subject can be materially transformed through interacting with objects.
TEMPO E LITERATURA: A OBRA O AMANUENSE BELMIRO, DE CYRO DOS ANJOS - UM OLHAR A PARTIR DA FILOSOFIA DE HENRI BERGSON
Authors: Jardim Alex Fabiano , Gusmão Warley Kelber
Published: July 2023

Pretendemos realizar um diálogo entre filosofia e literatura. De um lado teremos a obra literária O Amanuense Belmiro, do escritor mineiro Cyro dos Anjos; de outro, o pensamento do filósofo francês Henri Bergson. O pretexto que movimentará esse diálogo será o problema da subjetividade, do tempo e sua ação na vida humana, sua passagem. A leitura do livro O Amanuense Belmiro nos apresenta seu protagonista em uma situação conflituosa, pois, se o presente, com suas intermináveis exigências, não lhe permite acessar por completo o tão desejado passado vivido em Vila Caraíbas, de modo contrário, este mesmo passado atualizado em fragmentos, lampejos, o impede de viver por completo sua vida presente. Configura-se assim a gaiola (confinamento) temporal da qual Belmiro faz-se prisioneiro. E é particularmente esta característica da obra, isto é, sua concepção intrincada de tempo, que percorre todo o seu conjunto, que nos interessa, pois ela nos permitirá estabelecer uma aproximação com o pensamento de Henri Bergson, especificamente em relação a um conceito muito particular de sua filosofia, a duração: um modo de ver o tempo onde passado, presente e futuro convivem, misturam-se, interpenetram-se. As implicações deste modo de ver o tempo impactam diretamente nas ideias de vida interior e psicológica, criação, evolução, individualidade, percepção e memória.
A JUSTAPOSIÇÃO E O MECANISMO DE JUNÇÃO "E" COMO INDÍCIO DA COMPLEXIDADE NA ESCRITA INFANTIL
Authors: Filho Paulo Alexandre , Bertaglia Claudineia Peres
Published: July 2023

Diante da complexidade dos fenômenos da linguagem escrita, este trabalho tem como objetivo analisar os mecanismos de junção (MJ) utilizados em textos narrativos e argumentativos, de escreventes do 6° ano, do Ensino Fundamental II e da rede pública, em duas escolas estaduais do interior do estado de São Paulo. Para tanto, fez-se uma revisão da literatura científica, amparada na Linguística Funcional, para fins de embasamento teórico que fornecesse os subsídios necessários para conduzir esta investigação. A metodologia empregada foi de natureza quanti-qualitativa, tendo como instrumento para coleta de dados os gêneros “conto de terror” e “artigo de opinião”, trabalhados durante as aulas de Língua Portuguesa, obedecendo a estratégias de encaminhamento e comandas específicas. A hipótese inicial é de que, diferentemente da simplicidade associada à escrita infantil, os escreventes partem de situações concretas de enunciação, pois, nessa idade, imprimem, na escrita, suas experiências com as tradições da oralidade típica do ambiente familiar. Nesse sentido, as análises quantitativa e qualitativa permitiram obter conclusões acerca das diferentes acepções de sentido, possíveis nos diferentes e diversos usos dos mecanismos de junção (MJ), corroborando a ideia preliminar de que as situações de escrita, atreladas a determinados gêneros, requerem dos escreventes diferentes tipos de articuladores linguísticos.
Cuerpos bajo sospecha
Authors: Croce Marcela
Published: July 2023

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A TRADUÇÃO ORIENTADA PELO FÔNICO: UM OLHAR SAUSSURIANO PARA DUAS TRADUÇÕES DE LARANJA MECÂNICA
Authors: Czarnobai De Jorge Bianca
Published: July 2023

A tradução como objeto de estudo é bastante interessante para pensarmos sobre os usos da linguagem, o que pode implicar diversas áreas de conhecimento, incluindo os Estudos da Linguagem, a Linguística e os Estudos Literário. Em textos cuja orientação é de ordem fônica, como poemas, uma reflexão sobre língua e linguagem se faz fundamental enquanto lugares de produção de sentido. Esse também é o caso de Laranja Mecânica, de Anthony Burgess. Tendo em vista que o legado saussuriano apresenta profunda análise acerca de língua, linguagem e do valor que estas permitem instaurar, viabilizando uma vasta possibilidade de temas de estudo, a tradução também se vê facilmente amparada pela reflexão proposta na obra saussuriana. Assim, propomos a análise de traduções da referida obra segundo conceitos saussurianos como: língua, sistema, signo e valor. Esses conceitos se mostram fundamentais ao estudo da tradução, especialmente quando articulados e deslocados para as diferentes possibilidades de produção de sentido.
OS PRINCÍPIOS FUNDADORES DO PENSAMENTO BENVENISTIANO E A ABERTURA PARA ANÁLISE NA LITERATURA
Authors: Da Silva André Rodrigues , Neumann Daiane
Published: July 2023

O objetivo deste artigo é buscar os princípios fundadores da teorização benvenistiana, especificamente a partir do estudo dos pronomes e da subjetividade, a fim de atentar para o fato de que a construção desses princípios teóricos potencializa a interface entre língua e literatura, para uma abertura de análise em obras literárias. Será feita, com isso, uma discussão acerca da língua e linguagem, através da consideração sobretudo dos textos que compõem a quinta parte dos Problemas de Linguística Geral I intitulado “O homem na língua”. Ademais, é de nosso interesse refletir acerca de como essa reflexão teórica advinda do pensamento benvenistiano foi explorada por diferentes pesquisas que buscam a interface aqui propulsionada, no contexto francês e no brasileiro.
Distinct Frontoparietal Brain Dynamics Underlying the Co-Occurrence of Autism and ADHD
Authors: Watanabe Daichi , Watanabe Takamitsu
Published: July 2023

Previous diagnostic systems precluded the co-existence of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in one person; but, after many clinical reports, the diagnostic criteria were updated to allow their co-occurrence. Despite such a clinical change, the neurobiological bases underpinning the comorbidity remain poorly understood, and whether the ASD+ADHD condition is a simple overlap of the two disorders is unknown. Here, to answer this question, we compared the brain dynamics of high-functioning ASD+ADHD children with age-/sex-/IQ-matched pure ASD, pure ADHD, and typically developing (TD) children. Regarding autistic traits, the socio-communicational symptom of the ASD+ADHD children was explained by the same overstable brain dynamics as seen in pure ASD. In contrast, their ADHD-like traits were grounded on a unique neural mechanism that was unseen in pure ADHD: the core symptoms of pure ADHD were associated with the overly flexible whole-brain dynamics that were triggered by the unstable activity of the dorsal-attention network and the left parietal cortex; by contrast, the ADHD-like cognitive instability of the ASD+ADHD condition was correlated with the atypically frequent neural transition along a specific brain state pathway, which was induced by the atypically unstable activity of the frontoparietal control network and the left prefrontal cortex. These observations need to be validated in future studies using more direct and comprehensive behavioral indices, but the current findings suggest that the ASD+ADHD comorbidity is not a mere overlap of the two disorders. Particularly, its ADHD-like traits could represent a unique condition that would need a specific diagnosis and bespoke treatments.
Differential Modulation of GABAergic and Glutamatergic Neurons in the Ventral Pallidum by GABA and Neuropeptides
Authors: Neuhofer Daniela , Kalivas Peter
Published: July 2023

The ventral pallidum (VP) is an integral locus in the reward circuitry and a major target of GABAergic innervation of both D1-medium spiny neurons (MSNs) and D2-MSNs from the nucleus accumbens. The VP contains populations of GABAergic [VPGABA, GAD2(+), or VGluT(–)] and glutamatergic [VPGlutamate, GAD2(–), or VGluT(+)] cells that facilitate positive reinforcement and behavioral avoidance, respectively. MSN efferents to the VP exert opponent control over behavioral reinforcement with activation of D1-MSN afferents promoting and D2-MSN afferents inhibiting reward seeking. How this afferent-specific and cell type-specific control of reward seeking is integrated remains largely unknown. In addition to GABA, D1-MSNs corelease substance P to stimulate neurokinin 1 receptors (NK1Rs) and D2-MSNs corelease enkephalin to activate μ-opioid receptors (MORs) and δ-opioid receptors. These neuropeptides act in the VP to alter appetitive behavior and reward seeking. Using a combination of optogenetics and patch-clamp electrophysiology in mice, we found that GAD2(–) cells receive weaker GABA input from D1-MSN, but GAD2(+) cells receive comparable GABAergic input from both afferent types. Pharmacological activation of MORs induced an equally strong presynaptic inhibition of GABA and glutamate transmission on both cell types. Interestingly, MOR activation hyperpolarized VPGABA but not VGluT(+). NK1R activation inhibited glutamatergic transmission only on VGluT(+) cells. Our results indicate that the afferent-specific release of GABA and neuropeptides from D1-MSNs and D2-MSNs can differentially influence VP neuronal subtypes.
Metoda badawcza – problem z precyzją pojęcia w podręcznikach do metodologii badań na studiach pedagogicznych
Authors:   Uniwersytet Mikołaja Kopernika w Toruniu, Cuprjak Magdalena
Published: July 2023

This article is a polemic over the certainty (or uncertainty) of what a research method is and what is called a method in methodological books used in studies in the discipline of pedagogy. The topic is the result of problems faced by young adepts of science when asking questions, eg “is an interview a method or a technique”? In the literature on the subject, there are various classifications, and therefore terminological differences. Selected textbooks have been presented in terms of their specificity, incl. belonging to a discipline, affiliation of authors and research strategy. As an example of the vagueness of the concept of method, the differences in defining a case study – as a scheme, strategy and research method – are discussed. Definitional problems lie in various perspectives of understanding the method.
Metodologiczna rekonstrukcja warunków tworzenia wiedzy – wybrane zagadnienia – recenzja książki Danuty Urbaniak-Zając i Jacka Piekarskiego, Łódź: Wydawnictwo Uniwersytetu Łódzkiego, 2022
Authors:   Szkoła Doktorska Nauk Społecznych Uniwersytetu Łódzkiego, Jarota Martyna
Published: July 2023

The main purpose of the text is to present the problems surrounding the book Metodologiczna rekonstrukcja warunków tworzenia wiedzy – wybrane zagadnienia. These problems closely correspond with research practice and can be interpreted as an expression of concern for the quality of activities undertaken as part of the research process. The reader is also presented with the advantages and limitations of this publication.
The Determinants Of Economic Growth In North African Countries
Authors: Imleesh Mohammed Mahmoud
Published: July 2023

Economic growth is one of the most important indicators used in developing and evaluating the economic activity of developing countries, including North African countries, but economic growth faces several major economic challenges such as FDI, unemployment rate, inflation and exchange rate. This study used quantitative research, and data were collected by documentation method with secondary data since 2001-2020, Based on the results of the analysis by panel data regression, it was found that FDI is statistically significant, while it has a positive sign, which indicates that it has a positive impact on economic growth, If FDI  increase by1%, economic growth will increase by 0.684%, and there is no impact of inflation and unemployment rate on economic growth, and the exchange rate has a positive and significant impact on economic growth, as each increase leads by 1% in the exchange rate to a increase in economic growth by 0.420%, in future research other variables affecting economic growth, such as the volume of exports, import tariffs, taxes or government regulations.
DIPNECH: pragmatic approach, uncertainties, notable associations, and a proposal for an improved definition
Authors: Samhouri Bilal F , Halfdanarson Thorvardur R , Koo Chi Wan , McCarthy Cormac , Yi Eunhee S , Thomas Charles F , Ryu Jay H
Published: July 2023

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare, but increasingly recognized entity that primarily affects middle-aged and elderly women. It is characterized by abnormal proliferation of pulmonary neuroendocrine cells (PNECs) and is considered a preinvasive lesion for carcinoid tumorlets/tumors. Sometimes, DIPNECH is accompanied by constrictive bronchiolitis which usually manifests as chronic cough and/or dyspnea, along with airflow limitation on spirometry. The telltale imaging sign of DIPNECH is the presence of multiple noncalcified pulmonary nodules and mosaic attenuation on CT. However, these clinico-radiologic features of DIPNECH are characteristic but nonspecific; thus, histopathologic confirmation is usually necessary. DIPNECH has an indolent course and only rarely leads to respiratory failure or death; progression to overt neuroendocrine tumor (carcinoid) of the lung occurs in a minority of patients. Of available therapies, somatostatin analogs and mechanistic target of rapamycin inhibitors are the most promising. In this review, we provide an update regarding the diagnosis and management of DIPNECH and describe critical gaps in our understanding of this entity, including the central terms ‘diffuse’ and ‘idiopathic.’ We also summarize the inconsistencies in definitions employed by recent studies and discuss the pitfalls of the DIPNECH definitions proposed by the World Health Organization in 2021. In this context, we propose an objective and reproducible radio-pathologic case definition intended for implementation in the research realm and seeks to enhance homogeneity across cohorts. Furthermore, we discuss aspects of PNECs biology which suggest that PNEC hyperplasia may contribute to the pathogenesis of phenotypes of lung disease aside from constrictive bronchiolitis and carcinoid tumorlets/tumors. Finally, we steer attention to some of the most pressing and impactful research questions awaiting to be unraveled.