bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Learner’s Emotional Engagement in Online Learning Using Machine Learning Adam Robust Optimization Algorithm
Authors: Somu Renugadevi , Ashok Kumar Preethi
Published: June 2024

In online mode of teaching—learning process, which is prevailing in large in the recent years, the levels of involvement while taking part in these instructional activities—ranges from boredom to learning gain. It is a significant role of online educators to accurately and effectively determine their online learners’ engagement status in order to offer them individualized pedagogical support through interventions. This work thus focuses on processing the online video classes to analyze emotional engagement of the learners. On the basis of video face processing, an innovative pipeline is suggested. First, the face in the facial video of the dataset is detected using a multitask cascaded convolutional neural networks (MTCNN) framework designed for face detection. Then, using a single efficient convolutional neural network (CNN), the emotional features of each frame are obtained, and the appropriate emotions are forecasted. The engagement level is then determined using the weighted average of the assessed probabilities of the predicted emotions. This network is pretrained on face detection and fine‐tuned for identifying emotions on static images using a newly designed robust optimization technique. The three levels of student engagement—highly engaged, engaged, and disengaged—and their seven different emotions, happy, sad, angry, neutral, scared, surprise, and disgust, are all been quickly and simultaneously predicted using the generated facial features. The students’ facial recordings may all be processed secretly and instantly on their mobile device with this technology, so there is no need to transfer them elsewhere. The proposed model detects emotions and levels of engagement with a better accuracy of 97.45%.
Pancreatic Epithelial IL17/IL17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis
Authors: Castro-Pando Susana , Howell Rian M. , Li Le , Mascaro Marilina , Faraoni Erika Y. , Le Roux Olivereen , Romanin David , Tahan Virginia , Riquelme Erick , Zhang Yu , Kolls Jay K. , Allison James P. , Lozano Guillermina , Moghaddam Seyed J. , McAllister Florencia
Published: June 2024

IL17 is required for the initiation and progression of pancreatic cancer, particularly in the context of inflammation, as previously shown by genetic and pharmacological approaches. However, the cellular compartment and downstream molecular mediators of IL17-mediated pancreatic tumorigenesis have not been fully identified. This study examined the cellular compartment required by generating transgenic animals with IL17 receptor A (IL17RA), which was genetically deleted from either the pancreatic epithelial compartment or the hematopoietic compartment via generation of IL17RA-deficient (IL17-RA−/−) bone marrow chimeras, in the context of embryonically activated or inducible Kras. Deletion of IL17RA from the pancreatic epithelial compartment, but not from hematopoietic compartment, resulted in delayed initiation and progression of premalignant lesions and increased infiltration of CD8+ cytotoxic T cells to the tumor microenvironment. Absence of IL17RA in the pancreatic compartment affected transcriptional profiles of epithelial cells, modulating stemness, and immunological pathways. B7-H4, a known inhibitor of T-cell activation encoded by the gene Vtcn1, was the checkpoint molecule most upregulated via IL17 early during pancreatic tumorigenesis, and its genetic deletion delayed the development of pancreatic premalignant lesions and reduced immunosuppression. Thus, our data reveal that pancreatic epithelial IL17RA promotes pancreatic tumorigenesis by reprogramming the immune pancreatic landscape, which is partially orchestrated by regulation of B7-H4. Our findings provide the foundation of the mechanisms triggered by IL17 to mediate pancreatic tumorigenesis and reveal the avenues for early pancreatic cancer immune interception.

See related Spotlight by Lee and Pasca di Magliano, p. 1130
CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity
Authors: Mehta Naveen K. , Rakhra Kavya , Meetze Kristan A. , Li Bochong , Momin Noor , Chang Jason Y.H. , Wittrup K. Dane , Baeuerle Patrick A. , Michaelson Jennifer S.
Published: June 2024

Despite clinical evidence of antitumor activity, the development of cytokine therapies has been hampered by a narrow therapeutic window and limited response rates. Two cytokines of high interest for clinical development are interleukin 2 (IL2) and interleukin 12 (IL12), which potently synergize to promote the activation and proliferation of T cells and NK cells. However, the only approved human IL2 therapy, Proleukin, is rarely used in the clinic due to systemic toxicities, and no IL12 product has been approved to date due to severe dose-limiting toxicities. Here, we describe CLN-617, a first-in-class therapeutic for intratumoral (IT) injection that co-delivers IL2 and IL12 on a single molecule in a safe and effective manner. CLN-617 is a single-chain fusion protein comprised of IL2, leukocyte-associated immunoglobulin-like receptor 2 (LAIR2), human serum albumin (HSA), and IL12. LAIR2 and HSA function to retain CLN-617 in the treated tumor by binding collagen and increasing molecular weight, respectively. We found that IT administration of a murine surrogate of CLN-617, mCLN-617, eradicated established treated and untreated tumors in syngeneic models, significantly improved response to anti-PD1 checkpoint therapy, and generated a robust abscopal response dependent on cellular immunity and antigen cross-presentation. CLN-617 is being evaluated in a clinical trial in patients with advanced solid tumors (NCT06035744).
Figure S2 from Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma
Authors: Ward George A. , Zhang Zhiqiang , Jueliger Simone , Potapov Ilya S. , Davis Matthew P. , Boxall Adam R. , Taylor Jason , Keer Harold , Biondo Andrea , Lyons John F. , Sims Martin , Smyth Tomoko
Published: June 2024

Figure S2. Additional viability and cytokine data from each TCL CRISPR clone experiment. (Refers to Figure 1)
Brain MRI Injury Patterns across Gestational Age among Preterm Infants with Perinatal Asphyxia
Authors: Parmentier Corline E.J. , el Bakkali Loubna , Verhagen Elise A. , Steggerda Sylke J. , Alderliesten Thomas , Lequin Maarten H. , van de Pol Laura A. , Benders Manon J.N.L. , van Bel Frank , Koopman-Esseboom Corine , de Haan Timo R. , de Vries Linda S. , Groenendaal Floris
Published: June 2024

Introduction: Brain injury patterns of preterm infants with perinatal asphyxia (PA) are underreported. We aimed to explore brain magnetic resonance imaging (MRI) findings and associated neurodevelopmental outcomes in these newborns. Methods: Retrospective multicenter study included infants with gestational age (GA) 24.0–36.0 weeks and PA, defined as ≥2 of the following: (1) umbilical cord pH ≤7.0, (2) 5-min Apgar score ≤5, and (3) fetal distress or systemic effects of PA. Findings were compared between GA <28.0 (group 1), 28.0–31.9 (group 2), and 32.0–36.0 weeks (group 3). Early MRI (<36 weeks postmenstrual age or <10 postnatal days) was categorized according to predominant injury pattern, and MRI around term-equivalent age (TEA, 36.0–44.0 weeks and ≥10 postnatal days) using the Kidokoro score. Adverse outcomes included death, cerebral palsy, epilepsy, severe hearing/visual impairment, or neurodevelopment <-1 SD at 18–24 months corrected age. Results: One hundred nineteen infants with early MRI (n = 94) and/or MRI around TEA (n = 66) were included. Early MRI showed predominantly hemorrhagic injury in groups 1 (56%) and 2 (45%), and white matter (WM)/watershed injury in group 3 (43%). Around TEA, WM scores were highest in groups 2 and 3. Deep gray matter (DGM) (aOR 15.0, 95% CI: 3.8–58.9) and hemorrhagic injury on early MRI (aOR 2.5, 95% CI: 1.3–4.6) and Kidokoro WM (aOR 1.3, 95% CI: 1.0–1.6) and DGM sub-scores (aOR 4.8, 95% CI: 1.1–21.7) around TEA were associated with adverse neurodevelopmental outcomes. Conclusion: The brain injury patterns following PA in preterm infants differ across GA. Particularly DGM abnormalities are associated with adverse neurodevelopmental outcomes.
Food-Related Quality of Life in Inflammatory Bowel Disease: Translation and Validation of Food-Related Quality of Life to the Portuguese Language (FR-QoL-29-Portuguese)
Authors: Oliveira Raquel , Martins Viviana , Teixeira Laetitia , Tavares de Sousa Helena , Roseira Joana
Published: June 2024

Introduction: Food-related quality of life (FR-QoL) has been shown to be an important patient-reported outcome in inflammatory bowel disease (IBD). We aimed to translate and validate a Portuguese version of the FR-QoL-29. Methods: This was a case-control cross-sectional study undertaken at a tertiary hospital. After obtaining the original authors’ authorization, both forward and backward translations of the original FR-QoL-29 were performed by bilingual researchers. After an IBD expert’s revision and the input of a small group of patients, a final version was obtained. Portuguese IBD patients were prospectively recruited from the outpatient clinic of a tertiary hospital and completed the questionnaire at two timepoints (0 and 4 weeks). Reliability (internal consistency, test-retest, and intraclass correlation [ICC]), validity (content and convergent validity, and hypothesis testing using Spearman’s correlations), and responsiveness (Student t tests) were analysed. Results: 239 patients (mean age 50.1 [SD = 15.3 years], 56.5% female) and 87 (36.4%) patients answered the questionnaire at the first and second timepoints, respectively; 126 controls answered the questionnaire. Overall, the FR-QoL-29-Portuguese showed excellent internal consistency (Cronbach’s α = 0.97) and good test-retest reliability (ICC = 0.78 [95% CI: 0.64–0.85]). FR-QoL moderately correlated with health-related quality of life, measured by the SIBDQ-PT (R = 0.49; p < 0.05). Lastly, the questionnaire revealed appropriate responsiveness when patients reported an overall improvement in general well-being (mean improvement 25.88 [SD = 32.50]; p < 0.05). Discussion/Conclusions: We present an adaptation and validation of the FR-QoL-29 tool for Portuguese IBD patients. The FR-QoL-29-Portuguese is a reliable and valid tool shown to be responsive to changes in general well-being.
Related Clinical Factors of Platinum-Based Chemotherapy Resistance in Patients with Epithelial Ovarian Cancer
Authors: Xiong Zhuo , Ha Chunfang , Li Ruyue , Wu Mingyong , Wei Meng
Published: June 2024

Objective: Ovarian cancer is the second most common malignancy in women, but it is a fatal gynecological tumor. Although it has a standard treatment regimen, resistance to chemotherapy makes patients more prone to early recurrence, leading to poor survival rates. Therefore, this study investigated factors related to platinum resistance through a complete analysis of clinical data. Design: Clinical data of patients with ovarian cancer were collected, and the patients were categorized into platinum-sensitive and platinum-resistant groups. By comparing the differences in clinical data between the groups, the key factors affecting platinum resistance were analyzed. Participants/Materials, Setting, Methods: We collected the clinical data of patients with epithelial ovarian cancer (EOC) who were admitted to the Department of Oncology of the General Hospital of Ningxia Medical University between January 1, 2019, and December 31, 2020. We conducted univariate and multivariate analyses and evaluated overall survival and progression-free survival using the Kaplan-Meier method. Results: We enrolled 161 patients with EOC, of whom 124 demonstrated platinum sensitivity and 37 demonstrated platinum resistance after the initial platinum-based chemotherapy. Univariate analyses revealed that the International Federation of Gynecology and Obstetrics (FIGO) stage, neoadjuvant chemotherapy, and Fagotti score were associated with an increased risk of platinum resistance for the first recurrence. In multivariate logistic regression analysis, only Fagotti score and neoadjuvant chemotherapy were associated with an increased risk of platinum resistance (odds ratio: 0.372 and 0.328, 95% confidence interval: 0.160–0.863 and 0.141–0.762, p = 0.021 and 0.010, respectively). Limitations: The sample size of this study was relatively small because of nonstandard treatment of some patients, the absence of clinical data, and failure of follow-up. Conclusions: Patients with EOC exhibiting platinum resistance had a very poor prognosis. The Fagotti score and neoadjuvant chemotherapy appeared to increase the risk of platinum resistance at first recurrence.
Short- and Long-Term Outcome of Selective Reduction by Fetoscopy-Guided Bipolar Cord Coagulation in Monochronic Twin Pregnancies
Authors: Tang Huirong , Dai Chenyan , Yan Chenchen , Li Jie , Dai Yimin , Xiao Xian , Jin Liang , Hu Yali , Zheng Mingming
Published: June 2024

Introduction: The aim of this study was to assess the short- and long-term outcome of selective reduction by fetoscopy-guided bipolar cord coagulation in monochronic twin pregnancies. Methods: Retrospective analysis was conducted of a consecutive cohort of all monochorionic twin pregnancies treated with fetoscopy-guided bipolar cord coagulation between December 2015 and December 2022 in a single center in China. Results: A total of 43 monochronic twin pregnancies undergoing fetoscopy-guided bipolar cord coagulation were analyzed. There were 5 intrauterine deaths with an 88.4% (38/43) survival rate overall. The preterm premature rupture of the membranes rate was 13.2%, and the preterm birth before 37 and 32 weeks was 42.1% and 13.1%, respectively. An uptrend in the survival rate (78.9 vs. 95.8%, p = 0.086) and a downtrend of procedure time (30 vs. 16.5 min, p = 0.036) were observed over time (period 1 from December 2015 to December 2019 verses period 2 from January 2020 to December 2022). Long-term outcome was assessed in 94.6% (35/37) of survivors, and 91.4% (32/35) had normal neurodevelopmental outcome. Conclusion: Fetoscopy-guided bipolar cord coagulation for fetal reduction in complicated monochorionic twin pregnancies could achieve a favorable short- and long-term outcome, especially in experienced hands.
The Responses of Arterial Stiffness Parameter Beta-Derived Index of the Aorta and Illiac-Femoral Artery to Acute Hypovolemia in Rabbits
Authors: Ito Toshiro , Katsuda Shin-ichiro , Horikoshi Yuko , Funyu Toru , Hazama Akihiro , Shimizu Tsuyoshi , Shirai Kohji
Published: June 2024

Introduction: Acute hemorrhage decreases blood pressure (BP) and sometimes causes hypovolemic shock. At this time, peripheral arteries are supposed to contract and increase peripheral vascular resistance to raise BP. However, there has not been an adequate index of a degree of arterial stiffness. We assessed changes in arterial stiffness during rapid bleeding using new BP-independent vascular indices, aBeta and ifBeta, determined by applying the cardio-ankle vascular index theory to the elastic (aorta) and muscular (common iliac-femoral) arteries, respectively, in rabbits. Methods: Eleven Japanese white male rabbits were fixed at the supine position under pentobarbital anesthesia. Fifteen percent of the total blood volume was depleted at a rate of 2 mL/kg/min for 6 min; 15 min later, the withdrawn blood was re-transfused at the same rate. Pressure waves at the origin of the aorta (oA), distal end of the abdominal aorta (dA), distal end of the left common iliac artery (fA), and flow waves at oA were measured simultaneously. Beta was calculated using the following formula: beta = 2ρ/PP × ln(SBP/DBP) × PWV2, where ρ, SBP, DBP, and PP are blood density, systolic, diastolic, and pulse pressures, respectively. aBeta, ifBeta, and aortic-iliac-femoral beta (aifBeta) were calculated using aPWV, ifPWV, and aifPWV, respectively. Results: BP declined significantly at oA, dA, and fA during the acute bleeding. aBeta and aifBeta increased significantly from 3.7 and 5.0 before the bleeding (control) to 5.0 (about 34%) and 6.3 (about 26%) on average, while ifBeta decreased significantly from 20.5 before the bleeding to 17.1 (about 17%) after the completion of the bleeding. Reverse reactions of those indices were observed by transfusing the removed blood. Conclusion: Total arterial stiffness (aifBeta) increased; however, the elastic and muscular arteries stiffened and softened during the bleeding, respectively. These results would give useful diagnostic information during fall in BP.
Towards Interdisciplinary Collaboration: Surveying Dentists’ and Orthodontists’ Perspectives on Orofacial Myofunctional Disorders and Therapy
Authors: Van der Straeten Charis , Philibert Quinten , Bettens Kim , Verbeke Jolien , De Pauw Guy , Van Lierde Kristiane M.
Published: June 2024

Introduction: Children with malocclusion, combined with orofacial myofunctional disorders (OMDs), show increased risk of developing orthodontic problems and needs later in life. Speech-language therapists typically provide orofacial myofunctional therapy (OMT) after referral by dentists, orthodontists or ENT specialists. Interdisciplinary treatment is often advisable to prevent relapse after orthodontic treatment. OMDs and OMT are often found to be controversial topics by dentistry professionals. This study aimed to investigate self-reported knowledge and attitudes of Flemish dentists and orthodontists towards OMDs and OMT. Methods: A survey containing 32 items on demographics, self-reported knowledge of OMDs and OMT, attitudes towards OMDs, OMT, and its use in clinical practice, and referral behaviour was filled out by 48 general dentists (48/79, 61%) and 31 orthodontists (31/79, 39%). The impact of specialization, degree of experience and educational programme was also evaluated. Results: Fifty-six percent of all participants (44/79) reported insufficient to non-existent knowledge of OMT. Nevertheless, the general attitude towards the use of OMT was neutral (47%, 37/79) to (very) positive (48%, 38/79). Although they found correct, evidence-based knowledge on OMDs and OMT important, the majority indicated their formal training did not provide adequate information on OMDs (52%, 41/79) and OMT (62%, 49/79). Specialization showed significant effects, as orthodontists reported themselves knowledgeable on this topic significantly more often than general dentists (p < 0.001), and generally reported a more positive stance towards OMT (p = 0.022). Conclusion: Dentists and orthodontists indicated a general interest in the topic of OMDs and OMT, alongside an overall lack of information provided by formal education. Current findings suggest the necessity of re-evaluating current curricula on OMDs and OMT.
Two novel variants of the CAPN3 gene in Chinese patients with Limb-Girdle Muscular Dystrophy Recessive 1
Authors: Zhang Lulu , Zhang Yi , Han Chunru , Jiang Juean , Jiang Jianhua , Cai Xiuying , Yu Liqiang , Qi Huan , Fang Qi , Ding Dongxue
Published: June 2024

Introduction
Recessive mutations in the CAPN3 gene can lead to Limb-girdle muscular dystrophy Recessive 1 (LGMD R1). Targeted next-generation sequencing facilitates the discovery of new mutations linked with disease, owing to its ability to selectively enrich specific genomic regions.
Methods
We performed targeted next-generation sequencing of all exons of the CAPN3 gene in four patients with sporadic LGMD and further analyzed the effects of the novel identified variant using various software tools.
Results
We found 5 variants in CAPN3 gene in four patients, c.82_83insC (insertion mutation) and c.1115+2T>C (splicing mutation) are reported for the first time in CAPN3 (NM_000070.2). The bioinformatics analysis indicated that these two novel variants affected CAPN3 transcription as well as translation.
Discussion
Our findings reveal previously unreported splicing mutation and insertion mutation in CAPN3 gene, further expanding the pathogenic gene profile of LGMD.
Erratum: Ecological attributes of aquatic invertebrates in two water turbidity scenarios in a lake of the Pantanal, Brazil
Authors: Butakka Cristina Márcia de Menezes , Loverde-Oliveira Simoni Maria , Oliveira Valdeci Antonio de
Published: June 2024

The objective of this work was to determine the taxonomic structure and Functional Feeding Groups (FFGs) of benthic invertebrates and their roles in two different water turbidity scenarios in a floodplain lake in the Pantanal wetland (Sinhá Mariana Lake, Barão de Melgaço, state of Mato Grosso). We studied the benthic invertebrate fauna at 18 sampling sites in periods of high turbidity (HT) and low turbidity (LT) during high water (HW) and low water (LW). We hypothesize that the structure of Chironomidae assemblages (species and functional feeding groups) varies between sites in Sinhá Mariana Lake, and the density and diversity attributes of species in this family and their functional feeding groups are reduced under increased turbidity. Depth, water temperature, turbidity, pH, pCO₂, water color, and organic matter content of the sediment were analyzed in each sampling site. Chironomidae presented higher density and diversity in periods of high water (HW) in sites with low turbidity water (LT). The dominance increased in periods of low water (LW). The main FFGs were represented by collector-gatherers, while the smallest groups corresponded to shredder-herbivores (50% and 9% of the total abundance, respectively). Collector-gatherers (Aedokritus sp., Chironomus strenzkei, Goeldichironomus petiolicola, G. maculatus, Beardius phytophilus), predators (Ablabesmyia gr. annulata, Labrundinia sp. and Cryptochironomus brasiliensis) and shredder-herbivores (Asheum sp., Polypedilum sp., Polypedilum gr. fallax) predominated in high water (HW) periods. A change in the community structure from the HW to LW was evidenced, characterized by the substitution of collector-gatherers for collector-filterers. Notodiaptomus deitersi (Crustacea) was dominant in LW (dominance index = 10.9) and Aedokritus sp. (Insecta) in HW (dominance index = 5.4). Water turbidity and the hydrological cycle are important factors determining spatial and temporal patterns in communities, particularly changes in FFGs. Changes in turbidity in different sites and periods alter the structure of trophic communities and lead to questions about the main drivers of communities in Pantanal wetlands as areas of high ecological relevance for maintaining biodiversity.
Fitogeografia da Caatinga no núcleo de desertificação do Seridó (Brasil)
Authors: Pereira Neto Manoel Cirício
Published: June 2024

As formações vegetais da Caatinga são notavelmente diversas, superando outras florestas sazonalmente secas da América do Sul, com várias fácies fitogeográficas influenciadas pela distribuição, abundância e relação das espécies com os fatores ambientais. Este estudo visa identificar possíveis padrões fitogeográficos da Caatinga na região do Seridó potiguar, um núcleo de desertificação no Brasil, analisando a possível correlação com a diversidade de seus sistemas geoambientais. A pesquisa baseia-se no conceito de Paisagem e no método de análise fitossociológica proposto por Rodal, Sampaio e Figueiredo (2013) para o bioma da Caatinga. Os parâmetros fitossociológicos analisados incluem densidade (D), frequência (Fr), dominância (Dm) e índices de valor de importância (VI), além da diversidade hierárquica pelo índice de Shannon (H’) e de similaridade florística pelo Índice de Jaccard (IJ). Entre as espécies lenhosas mais abundantes destacam-se a Catingueira (Cenostigma pyramidale (Tul.) E. Gagnon & G.P. Lewis), Marmeleiro (Croton blanchetianus Baill.), Pereiro (Aspidosperma pyrifolium Mart. & Zucc.) e Jurema-Preta (Mimosa tenuiflora (Willd.) Poir.). Os índices de diversidade Shannon (H' = 1,31 a 2,48) e Simpson (1-D = 0,64 a 0,89) revelaram maior riqueza florística nas áreas serranas, como o Maciço Residual da Formiga (2,48 H’ e 0,89 1-D) e o Planalto da Borborema (2,86 H’ e 0,87 1-D), enquanto o índice de similaridade de Jaccard indicou maior semelhança entre pontos dentro do mesmo sistema geoambiental, sugerindo que condições similares favorecem a similaridade florística. A densidade fitogeográfica variou entre 0,007 e 0,034 ao longo do transecto florístico analisado. Esses dados são fundamentais para direcionar esforços de conservação em regiões afetadas pela desertificação. No Seridó potiguar, observa-se um padrão fitogeográfico curioso com distintas fácies de caatingas, refletindo os sistemas geoambientais e a degradação ambiental.
Estudo de uma intervenção remota com adolescentes em situação de vulnerabilidade na pandemia do COVID-19
Authors: Britto Ana Luisa Sanders , Silva Marcela Dantas dos Santos , Castilho Pedro Teixeira
Published: June 2024

Amparada nos conceitos de biopolítica e necropolítica, e na psicanálise lacaniana, a pesquisa busca refletir sobre os efeitos da pandemia nos adolescentes em situação de vulnerabilidade participantes do projeto Desembola na Ideia. A (não) implicação dos adolescentes nas medidas de proteção contra o vírus exigiu a criação de espaços virtuais para oficinas e acolhimento para que houvesse uma via de endereçamento da angústia dos jovens. Além disso, analisa os modos de subjetivação que foram suscitados na experiência de atenção psicossocial nos grupos remotos durante esse período. Como metodologia, utilizam-se vinhetas clínicas colhidas nos grupos e discutidas em três categorias de análise. O atendimento remoto apresentou uma função de “prótese” para a manutenção de algo do laço social, diante do desamparo colocado pela pandemia e pela violência já vivida pelos adolescentes.
Adoção tardia, filiação e devolução de crianças: uma realidade brasileira
Authors: Souza Barbara Manfroni Amaral de , LoBianco Anna Carolina
Published: June 2024

O artigo trata da questão da adoção a partir da experiência de uma das autoras no Tribunal de Justiça do Rio de Janeiro. Apresenta as formas de adoção presentes na sociedade brasileira – algumas em conformidade com as leis outras realizadas de maneira informal. Examina as vicissitudes da adoção, entre elas os casos conhecidos como de “devolução”. Procura, em seguida, discutir suas consequências para o psiquismo, a partir da psicanálise. Conclui, utilizando fragmentos da clínica, que se trata de escutar os envolvidos – trabalho que envolve a equipe de profissionais – para facilitar os caminhos através dos quais o sujeito venha a fazer para si um lugar e se exercer como sujeito do desejo.
Do mal-estar ao educar: desdobramentos do diálogo entre psicanálise e educação
Authors: Monteiro Elisabete Aparecida , Dias Mariângela de Andrade Máximo
Published: June 2024

Cet article se penche sur les effets de la rencontre entre la psychanalyse et l’éducation, dont l’origine est à situer dans une période initiale des écrits de Freud, lorsque celui-ci concevait encore la prophylaxie des névroses par le biais d’une réforme de l’éducation et de la culture. Au regard de la théorisation de la pulsion de mort et de la compulsion de répétition, cet idéal se révéla une illusion. Sur la base d’études importantes dans le champ de la connexion psychanalyse-éducation, on propose ici une analyse de l’actuel scénario des idéaux qui entourent l’éducation, et notamment le pari visant, dans un cadre prétendument scientifique, à former des élèves cognitivement et émotionnellement idéaux. Ce parcours nous permet d’identifier une crise proportionnelle au volume de théories de l’éducation, ce qui justifie alors qu’on situe la psychanalyse comme voie privilégiée par laquelle il est possible de redimensionner les idéaux qui se posent dans ce champ
A voracidade do supereu e a anorexia na adolescência
Authors: Pena Dayane Costa de Souza , Marcos Cristina Moreira
Published: June 2024

Neste artigo, abordamos pela psicanálise as implicações de um supereu voraz na anorexia durante a adolescência. Para tanto, evidenciamos a adolescência enquanto um marco no processo de subjetivação, que convoca um outro posicionamento em relação ao sexual e ao desejo. A anorexia pode aparecer como uma via de posicionamento do sujeito diante da questão do sexual. Nesse caso, a voz do supereu convocada como uma reposta ao dilema adolescente conduz o sujeito a uma armadilha, na qual o gozo é resultado da renúncia e cujo alto preço se faz ver em um corpo devorado pela voracidade e tirania do supereu.
Faz de conta que consigo comer: estudo de caso de uma criança com fibrose cística
Authors: Farias Gisely , Cunha Maiara Pereira
Published: June 2024

The objective was to report the psychoanalytic psychotherapy process of a 6 year old girl years with eating difficulties. Follow-up was carried out in a psychology school clinic, with the main complaint of oral refusal since the age of four months. This refusal started during a hospital stay in which the diagnosis of Cystic Fibrosis was discovered. Were 24 sessions were held with the patient and 4 sessions with her parents, to get to know the life history of the child and provide a space for speech and guidance for family members.
Throughout the follow-up, food was the main theme of the sessions, which were guided by the child and interpreted by the therapist. This process allowed the child to reframe his relationship with food and became interested in it.
Serguei Eisenstein: a biblioteca como espelho de uma obra
Authors: Barros Erivoneide , Jallageas Neide , Ackerman Ada
Published: June 2024

Entrevista com a pesquisadora francesa Ada Ackerman sobre seu trabalho de investigação e análise realizado na vasta biblioteca do cineasta letão soviético Serguei Mikhailóvitch Eisenstein. A entrevista é antecedida por uma breve contextualização do percurso metodológico da pesquisadora no lendário Gabinete S. M. Eisenstein, que, por mais de cinquenta anos, abrigou a biblioteca do cineasta, no coração de Moscou.
Tolstoï, écrivain de la différence et de la conversion éthique
Authors: Colin Yoann
Published: June 2024

We propose to read Tolstoy's novel Resurrection as allowing us to think about ethical conversion, that is, the metamorphosis of an ordinarily selfish and self-interested individual into a man acting in favor of others – which would be a possible incarnation of Levinas's thought, explicitly influenced by Tolstoy's work.
Saber viver, saber morrer: Hadji Murat, ou o poema da força
Authors: Matoso Ana
Published: June 2024

Este artigo debruça-se sobre Hadji Murat (1912), novela póstuma de Tolstói, em que o autor revisita o topus do Cáucaso e recria os últimos meses de vida do lendário herói da resistência. A leitura que se faz aqui desta obra singular, e das sucessivas revisões por que passou até chegar à sua forma definitiva, tem como ponto de partida a reflexão de Simone Weil sobre a Ilíada como um “poema da força”.
Tolstoy Against Things: Ostranenie, Pragmatic Conversions and Natural Attitude
Authors: Pousson Guilhem
Published: June 2024

The article discusses Viktor Shklovsky's concept of defamiliarization (ostranenie) from a broad perspective, including criticisms of it, its contemporary ramifications and even parallels, such as the Brechtian V-effekt. The author then moves on to a broad approach of Lev Tolstoy's work from the perspective of the previous considerations regarding the shklovskian term, bringing to light various particularities of Tolstoyan poetics that tension Shklovsky's formulations.
Um conceito de classe
Authors: Santiago Homero
Published: June 2024

Com o conceito de “multidão”, o filósofo italiano Antonio Negri quer designar o surgimento de um novo sujeito coletivo capaz de fazer frente ao domínio capitalista tal como tomou forma no mundo contemporâneo, o que ele nomeia “Império”. Daí a centralidade da multidão na trilogia que Negri publicou nos últimos anos com Michael Hardt: Império, Multidão, Commonwealth. Uma peculiaridade do conceito, reiterada por Negri, é consistir num “conceito de classe”. O que isso quer dizer? Nosso propósito é, partindo dessa indicação, retomar o fio do surgimento da “multidão” nos textos negrianos da década de 70, mostrar como o conceito é tomado a Espinosa (Negri sempre o dá como um conceito “espinosano”) e por fim, com base no percurso, entender esse aspecto “classista” da multidão negriana e espinosana. Com efeito, a partir de Espinosa o que Negri descobre é uma nova forma de pensar a classe explorada pelo capital; com o conceito de multidão ele consegue formular um conceito não empírico de classe, o único que, ao seu ver, daria conta de designar, hoje, a classe que pode enfrentar o Império.
Vigotski: notas para uma psicologia geral e concreta das emoções/afetos
Authors: Toassa Gisele
Published: June 2024

Este artigo sustenta que o projeto de psicologia de L.S. Vigotski organiza-se segundo uma estrutura triádica, dividindo-se em psicologia geral, particular e concreta – expressão de seu compromisso com a edificação de uma psicologia científica fundada no materialismo dialético. Descreve, brevemente, os percalços que têm afetado estudos mais detalhados da obra vigotskiana e problematiza presença de Espinosa na obra do autor. A partir disso, trata do compromisso de Vigotski em compor, em quadro único, uma psicologia das emoções/afetos em que coubessem as múltiplas manifestações da vida emocional humana, vivenciais e comportamentais. Expõe a extrema importância da filosofia de Espinosa nas ideias vigotskianas sobre a regulação dos afetos. Também, indica algumas ideias inspiradas em Espinosa para abordagem dos afetos no campo da “psicologia concreta da personalidade/pessoa”.
Espinosa Revolucionário
Authors: Oliveira Fernando Bonadia de
Published: June 2024

Maquiavel, Espinosa e Marx – sempre em contraposição a Hobbes, Rousseau e Hegel – são tomados por Antonio Negri, repetidas vezes, como filósofos ligados à revolução. Neste artigo será destacada a construção da imagem de Espinosa como um revolucionário, procurando atentar para as posições críticas de Negri em relação à ideia de mediação. O objetivo é explicar, a partir de certas passagens de A anomalia selvagem, como esta imagem pode ganhar alcance histórico e político como projeto presente, sobretudo na perspectiva apontada por Negri & Hardt em certa passagem de Multidão.
Myocardial Inflammation in Heart Failure With Reduced and Preserved Ejection Fraction
Authors: Alcaide Pilar , Kallikourdis Marinos , Emig Ramona , Prabhu Sumanth D.
Published: June 2024

Heart failure (HF) is characterized by a progressive decline in cardiac function and represents one of the largest health burdens worldwide. Clinically, 2 major types of HF are distinguished based on the left ventricular ejection fraction (EF): HF with reduced EF and HF with preserved EF. While both types share several risk factors and features of adverse cardiac remodeling, unique hallmarks beyond ejection fraction that distinguish these etiologies also exist. These differences may explain the fact that approved therapies for HF with reduced EF are largely ineffective in patients suffering from HF with preserved EF. Improving our understanding of the distinct cellular and molecular mechanisms is crucial for the development of better treatment strategies. This article reviews the knowledge of the immunologic mechanisms underlying HF with reduced and preserved EF and discusses how the different immune profiles elicited may identify attractive therapeutic targets for these conditions. We review the literature on the reported mechanisms of adverse cardiac remodeling in HF with reduced and preserved EF, as well as the immune mechanisms involved. We discuss how the knowledge gained from preclinical models of the complex syndrome of HF as well as from clinical data obtained from patients may translate to a better understanding of HF and result in specific treatments for these conditions in humans.
Revisiting Cardiac Biology in the Era of Single Cell and Spatial Omics
Authors: Palmer Jack A. , Rosenthal Nadia , Teichmann Sarah A. , Litvinukova Monika
Published: June 2024

Throughout our lifetime, each beat of the heart requires the coordinated action of multiple cardiac cell types. Understanding cardiac cell biology, its intricate microenvironments, and the mechanisms that govern their function in health and disease are crucial to designing novel therapeutical and behavioral interventions. Recent advances in single-cell and spatial omics technologies have significantly propelled this understanding, offering novel insights into the cellular diversity and function and the complex interactions of cardiac tissue. This review provides a comprehensive overview of the cellular landscape of the heart, bridging the gap between suspension-based and emerging in situ approaches, focusing on the experimental and computational challenges, comparative analyses of mouse and human cardiac systems, and the rising contextualization of cardiac cells within their niches. As we explore the heart at this unprecedented resolution, integrating insights from both mouse and human studies will pave the way for novel diagnostic tools and therapeutic interventions, ultimately improving outcomes for patients with cardiovascular diseases.
Cervicocerebral Atherosclerosis Burden Increases Long‐Term Mortality in Patients With Ischemic Stroke or Transient Ischemic Attack
Authors: Lainelehto Kati , Pienimäki Juha‐Pekka , Savilahti Sirpa , Huhtala Heini , Numminen Heikki , Putaala Jukka
Published: June 2024

Background

The influence of burden of atherosclerosis in the brain supplying arteries on mortality in patients with acute ischemic stroke or transient ischemic attack is poorly known. We assessed whether total burden of atherosclerosis within cervicocerebral arteries is associated with long‐term mortality.

Methods and Results

A total of 406 patients (median age, 71.8 years; 57.9% male) with acute ischemic stroke or transient ischemic attack were included and their cervicocerebral arteries imaged with computed tomography angiography. The presence of atherosclerotic findings was scored for 25 artery segments and points were summed as a Cervicocerebral Atherosclerosis Burden (CAB) score, analyzed as quartiles. Data on all‐cause mortality came from Statistics Finland. After a median follow‐up of 7.3 years, 147 (33.5%) patients had died. Compared with surviving patients, those who died had a higher median CAB score (5, interquartile range 2–10 versus 11, 7–16;
P
<0.001). Cumulative mortality increased from 8.9% (95% CI, 7.0–10.8) in the lowest to 61.4% (95% CI, 55.4–67.4) in the highest quartile of CAB score. Adjusted for demographics, cardiovascular risk factors, secondary preventive medication, and admission National Institute of Health Stroke Scale score, every CAB score point increased probability of death by 3%. Analyzed in quartiles, the highest CAB quartile was associated with a 2.5‐fold likelihood of all‐cause mortality.

Conclusions

The main findings of our study were the increasing mortality with the total burden of computed tomography angiography‐defined atherosclerosis in the brain supplying arteries after ischemic stroke or transient ischemic attack and that the CAB score—integrating this pathology—independently increased all‐cause mortality.
Association of Anthropometric Indices With Midlife Cardiovascular Risk in Young Individuals Without Obesity and Traditional Risk Factors
Authors: Masrouri Soroush , Tamehri Zadeh Seyed Saeed , Afaghi Siamak , Hadaegh Farzad , Khalili Davood , Shapiro Michael D.
Published: June 2024

Background

The aim of this study was to assess how early‐adulthood body mass index (BMI) and waist circumference (WC) relate to long‐term cardiovascular structure, function, and prognosis in individuals without obesity and with low cardiovascular risk factor (CVRF) burden.

Methods and Results

A total of 2024 participants aged 18 to 30 from the CARDIA (Coronary Artery Risk Development in Young Adults) study, without obesity and with low CVRFs defined as the absence of cardiovascular disease (CVD), diabetes, hypertension, current smoking, and dyslipidemia were included. A CVRF‐optimal subgroup was also defined, with blood pressure<120/80 mm Hg, fasting glucose <100 mg/dL, total cholesterol <200, low‐density lipoprotein cholesterol <130, and women with high‐density lipoprotein cholesterol ≥50 mg/dL. Coronary artery calcification, carotid intima‐media thickness, left ventricular mass, left ventricular ejection fraction, longitudinal peak systolic strain, and diastolic function were assessed in midlife. Cox regression was used to calculate hazard ratios of BMI and WC for all‐cause death and CVD events. Logistic regression was used to estimate odds ratios for subclinical CVD. Over 33.9 years (median follow‐up), 5.2% (n=105) died, and 2.6% (n=52) had CVD events. Each 1‐SD BMI increase was associated with 27% (95% CI, 1.10–1.47), 24% (1.08–1.43), 42% (1.20–1.68), 28% (1.05–1.57), 51% (1.20–1.90), and 49% (1.10–2.02) higher odds of coronary artery calcification presence, increased carotid intima‐media thickness, left ventricular hypertrophy, reduced left ventricular ejection fraction, low longitudinal peak systolic strain, and diastolic dysfunction, respectively, in the CVRF‐low group. Generally, similar associations were found for WC and in the CVRF‐optimal subgroup. No significant associations between BMI and WC with CVD and death were found.

Conclusions

Elevations in BMI and WC among young low‐risk individuals, even within the nonobesity range, are associated with midlife cardiovascular health.
On the identity of species of the huntsman spider genus Thelcticopis Karsch, 1884 (Araneae: Sparassidae: Sparianthinae) from India, Myanmar, Pakistan, and Sri Lanka
Authors: SANKARAN PRADEEP M. , SHERWOOD DANNIELLA , JÄGER PETER
Published: June 2024

The species of the genus Thelcticopis Karsch, 1884 from India, Myanmar, Pakistan, and Sri Lanka are reviewed. Stasina nalandica Karsch, 1892 and S. paripes (Karsch, 1879) are re-transferred to the genus Thelcticopis. Thelcticopis ajax Pocock, 1901, T. bicornuta Pocock, 1901, T. birmanica Thorell, 1895 stat. rev., T. hercules Pocock, 1901, T. moolampilliensis Sunil Jose & Sebastian, 2007, T. nalandica (Karsch, 1892) comb. rest., T. paripes (Karsch, 1879) comb. rest., T. picta (Thorell, 1887), T. rufula Pocock, 1901, T. serambiformis Strand, 1907, and T. virescens Pocock, 1901 are diagnosed, redescribed, and/or illustrated based on type and/or freshly collected material, and their current distributional records are mapped. The female of T. virescens is described for the first time. The type locality of Thelcticopis goramensis (Thorell, 1881) is situated in Indonesia, Maluku, not in Malaysia. Thelcticopis bifasciata (Thorell, 1891), and T. fasciata (Thorell, 1897) are proposed as nomina dubia as the holotypes are immature and their identity cannot be fully elucidated. Thelcticopis ancorum Dyal, 1935 and T. telonotata Dyal, 1935 from Lahore, Punjab are considered species incertae sedis, and the subfamily Sparianthinae is most likely not distributed in Pakistan.
Genetic Variability, Heritability and Expected Genetic Advance of Yield and Yield Related Traits in Desi Type Chickpea (Cicer Arietinum L.) at Bule Hora, Southern Ethiopia
Authors: Itana Taera , Mohammed Wassu , Abady Seltene
Published: June 2024

Chickpea is one of most important pulse crops in Ethiopia. Despite its significance, the national average chickpea yield is low due to many constraints of which the unavailability of improved varieties for each growing and potential area. This research was conducted to evaluate genetic variability, heritability, and expected genetic advance of yield and yield related traits in chickpea genotypes. It was conducted at Bule Hora during 2022/23 cropping season that 36 Desi type of chickpea genotypes were evaluated using a 6 x 6 simple lattice design. The results of the analysis of variance showed the presence of significant variations among genotypes for nine characteristics. In this study, the phenotypic variance was higher than the genotypic variance for all the traits studied. However, the difference between phenotypic and genotypic variances was low, ranging from 0.05 to 5.46 for four traits, and the difference between phenotypic and genotypic coefficients of variation was <5% (1.89 to 4.32%) for six of nine traits. Furthermore, Phenotypic (PCV) and genotypic (GCV) coefficient of variations ranged from 5.32 to 41.77% and 3.43 to 37.45%, respectively. Heritability (H2) in broad sense and genetic advance as percent of mean (GAM) ranged from 23.91 to 80.40 and 5.89 to 69.18%, respectively. The estimates of GCV and PCV, H2 and GAM were high for number of pods per plant, seeds per plant in gram, and grain yield.
Innovating the Future: Unveiling the Initial Iteration of the Pragmatic Framework for Product Managers
Authors: Pattyn Frederic
Published: June 2024

Context: This study introduces the Pragmatic Framework for Product Managers, a tool developed to enhance the understanding and application of product management activities. Objectives: The aim is to provide a comprehensive overview of Product Manager (PM) activities that positively impact efficiency, business growth, budget control, user satisfaction, and release processes. The framework is intended to aid decision-making, training, and clarifying the PM role, ultimately contributing to product success. Methods: A systematic literature review of 134 studies was conducted to develop the PFPM. This extensive research led to identifying and classifying 122 activities into 33 categories within 6 domains, forming a robust framework for product managers. Results: The PFPM, in its initial iteration, represents a minimal viable product of the framework. The research findings highlight the framework’s potential for future refinement, particularly in the context of software startups. Conclusion: The PFPM significantly affects software companies' product decision-making, PM training, and role transparency. It is a valuable resource for researchers and practitioners in Software Product Management (SPM), Requirement Engineering (RE), New Product Development (NPD), and innovation. The framework paves the way for future studies focused on the unique dynamics of PM activities in the software startup ecosystem.
Wind Speed Prediction in Jerusalem Using Machine Learning Algorithms: A Case Study of Using ANFIS and KNNR
Authors: Abuayyash Khalil , Alsamamra Husain , Teir Musa , Doufesh Hazem
Published: June 2024

Wind energy is acknowledged for its status as a renewable energy source that offers several advantages, including its low cost of electricity generation, abundant availability, high efficiency, and minimal environmental impact. The prediction of wind speed using machine learning algorithms is crucial for various applications, such as wind energy planning and urban development. This paper presents a case study on wind speed prediction in Palestine Jerusalem city using the Adaptive Neuro-Fuzzy Inference System (ANFIS) and K-Nearest Neighbors Regression (KNNR) algorithms. The study evaluates their performance using multiple metrics, including root mean square (RMSE), bias, and coefficient of determination R2. ANFIS demonstrates good accuracy with lower RMSE (0.196) and minimal bias (0.0003). However, there is room for improvement in capturing overall variability (R2 = 0.15). In contrast, KNNR exhibits a higher R2 (0.4093), indicating a better fit, but with a higher RMSE (1.4209). These results demonstrated the potential of machine learning algorithms in wind speed prediction, which can lead to optimize the wind energy generation at specific site, and reducing the cost of energy production. This study provides insights into the applicability of ANFIS and KNNR in wind speed prediction for Jerusalem and suggests future research directions. The outcomes have practical implications for wind energy planning, urban development, and environmental assessments in similar regions.