bluuebunny/crossref_metadata_2025 huggingface dataset:
Search for Venous Endothelial Biomarkers Heralding Venous Thromboembolism in Space: A Qualitative Systematic Review of Terrestrial Studies
Authors: Harris Katie , Laws Jonathan Michael , Elias Antoine , Green David Andrew , Goswami Nandu , Jordan Jens , Kamine Tovy Haber , Mazzolai Lucia , Petersen Lonnie G. , Winnard Andrew James , Weber Tobias
Published: April 2022

Background: The recent discovery of a venous thrombosis in the internal jugular vein of an astronaut has highlighted the need to predict the risk of venous thromboembolism in otherwise healthy individuals (VTE) in space. Virchow’s triad defines the three classic risk factors for VTE: blood stasis, hypercoagulability, and endothelial disruption/dysfunction. Among these risk factors, venous endothelial disruption/dysfunction remains incompletely understood, making it difficult to accurately predict risk, set up relevant prophylactic measures and initiate timely treatment of VTE, especially in an extreme environment.

Methods: A qualitative systematic review focused on endothelial disruption/dysfunction was conducted following the guidelines produced by the Space Biomedicine Systematic Review Group, which are based on Cochrane review guidelines. We aimed to assess the venous endothelial biochemical and imaging markers that may predict increased risk of VTE during spaceflight by surveying the existing knowledge base surrounding these markers in analogous populations to astronauts on the ground.

Results: Limited imaging markers related to endothelial dysfunction that were outside the bounds of routine clinical practice were identified. While multiple potential biomarkers were identified that may provide insight into the etiology of endothelial dysfunction and its link to future VTE, insufficient prospective evidence is available to formally recommend screening potential astronauts or healthy patients with any currently available novel biomarker.

Conclusion: Our review highlights a critical knowledge gap regarding the role biomarkers of venous endothelial disruption have in predicting and identifying VTE. Future population-based prospective studies are required to link potential risk factors and biomarkers for venous endothelial dysfunction to occurrence of VTE.
Kr-h1, a Cornerstone Gene in Insect Life History
Authors: He Qianyu , Zhang Yuanxi
Published: April 2022

Insect life cycle is coordinated by hormones and their downstream effectors. Krüppel homolog1 (Kr-h1) is one of the crucial effectors which mediates the actions of the two critical hormones of insects, the juvenile hormone (JH) and 20-hydroxyecdysone (20E). It is a transcription factor with a DNA-binding motif of eight C2H2 zinc fingers which is found to be conserved among insect orders. The expression of Kr-h1 is fluctuant during insect development with high abundance in juvenile instars and lower levels in the final instar and pupal stage, and reappearance in adults, which is governed by the coordination of JH, 20E, and miRNAs. The dynamic expression pattern of Kr-h1 is closely linked to its function in the entire life of insects. Over the past several years, accumulating studies have advanced our understanding of the role of Kr-h1 during insect development. It acts as a universal antimetamorphic factor in both hemimetabolous and holometabolous species by directly inhibiting the transcription of 20E signaling genes Broad-Complex (Br-C) and Ecdysone induced protein 93F (E93), and steroidogenic enzyme genes involved in ecdysone biosynthesis. Meanwhile, it promotes vitellogenesis and ovarian development in the majority of studied insects. In addition, Kr-h1 regulates insect behavioral plasticity and caste identity, neuronal morphogenesis, maturation of sexual behavior, as well as embryogenesis and metabolic homeostasis. Hence, Kr-h1 acts as a cornerstone regulator in insect life.
Characterization of a Novel Creeping Tartary Buckwheat (Fagopyrum tataricum) Mutant lazy1
Authors: Liang Chenggang , Wei Chunyu , Wang Li , Guan Zhixiu , Shi Taoxiong , Huang Juan , Li Bin , Lu Yang , Liu Hui , Wang Yan
Published: April 2022

Gravity is known as an important environmental factor involved in the regulation of plant architecture. To identify genes related to the gravitropism of Tartary buckwheat, a creeping line was obtained and designated as lazy1 from the mutant bank by 60Co-γ ray radiation. Genetic analysis indicated that the creeping phenotype of lazy1 was attributed to a single recessive locus. As revealed by the horizontal and inverted suspension tests, lazy1 was completely lacking in shoot negative gravitropism. The creeping growth of lazy1 occurred at the early seedling stage, which could not be recovered by exogenous heteroauxin, hormodin, α-rhodofix, or gibberellin. Different from the well-organized and equivalent cell elongation of wild type (WT), lazy1 exhibited dilated, distorted, and abnormally arranged cells in the bending stem. However, no statistical difference of indole-3-acetic acid (IAA) levels was found between the far- and near-ground bending sides in lazy1, which suggests that the asymmetric cell elongation of lazy1 was not induced by auxin gradient. Whereas, lazy1 showed up-expressed gibberellin-regulated genes by quantitative real-time PCR (qRT-PCR) as well as significantly higher levels of gibberellin, suggesting that gibberellin might be partly involved in the regulation of creeping growth in lazy1. RNA sequencing (RNA-seq) identified a number of differentially expressed genes (DEGs) related to gravitropism at stages I (before bending), II (bending), and III (after bending) between WT and lazy1. Venn diagram indicated that only Pectate lyase 5 was down-expressed at stages I [Log2 fold change (Log2FC): −3.20], II (Log2FC: −4.97), and III (Log2FC: −1.23) in lazy1, compared with WT. Gene sequencing revealed that a fragment deletion occurred in the coding region of Pectate lyase 5, which induced the destruction of a pbH domain in Pectate lyase 5 of lazy1. qRT-PCR indicated that Pectate lyase 5 was extremely down-expressed in lazy1 at stage II (0.02-fold of WT). Meanwhile, lazy1 showed the affected expression of lignin- and cellulose-related genes and cumulatively abnormal levels of pectin, lignin, and cellulose. These results demonstrate the possibility that Pectate lyase 5 functions as the key gene that could mediate primary cell wall metabolism and get involved in the asymmetric cell elongation regulation of lazy1.
The Role of Hydraulic Failure in a Massive Mangrove Die-Off Event
Authors: Gauthey Alice , Backes Diana , Balland Jeff , Alam Iftakharul , Maher Damien T. , Cernusak Lucas A. , Duke Norman C. , Medlyn Belinda E. , Tissue David T. , Choat Brendan
Published: April 2022

Between late 2015 and early 2016, more than 7,000 ha of mangrove forest died along the coastline of the Gulf of Carpentaria, in northern Australia. This massive die-off was preceded by a strong 2015/2016 El Niño event, resulting in lower precipitation, a drop in sea level and higher than average temperatures in northern Australia. In this study, we investigated the role of hydraulic failure in the mortality and recovery of the dominant species, Avicennia marina, 2 years after the mortality event. We measured predawn water potential (Ψpd) and percent loss of stem hydraulic conductivity (PLC) in surviving individuals across a gradient of impact. We also assessed the vulnerability to drought-induced embolism (Ψ50) for the species. Areas with severe canopy dieback had higher native PLC (39%) than minimally impacted areas (6%), suggesting that hydraulic recovery was ongoing. The high resistance of A. marina to water-stress-induced embolism (Ψ50 = −9.6 MPa), indicates that severe water stress (Ψpd < −10 MPa) would have been required to cause mortality in this species. Our data indicate that the natural gradient of water-stress enhanced the impact of El Niño, leading to hydraulic failure and mortality in A. marina growing on severely impacted (SI) zones. It is likely that lowered sea levels and less frequent inundation by seawater, combined with lower inputs of fresh water, high evaporative demand and high temperatures, led to the development of hyper-salinity and extreme water stress during the 2015/16 summer.
Rapid Detection of Wheat Ears in Orthophotos From Unmanned Aerial Vehicles in Fields Based on YOLOX
Authors: Zhaosheng Yao , Tao Liu , Tianle Yang , Chengxin Ju , Chengming Sun
Published: April 2022

Wheat ears in unmanned aerial vehicles (UAV) orthophotos are characterized by occlusion, small targets, dense distribution, and complex backgrounds. Rapid identification of wheat ears in UAV orthophotos in a field environment is critical for wheat yield prediction. Three improvements were achieved based on YOLOX-m: mosaic optimized, using BiFPN structure, and attention mechanism, then ablation experiments were performed to verify the effect of each improvement. Three scene datasets were established: images were acquired during three different growing periods, at three planting densities, and under three scenarios of UAV flight heights. In ablation experiments, three improvements had increased recognition accuracies on the experimental dataset. Compared the accuracy of the standard model with our improved model on three scene datasets. Our improved model during three different periods, at three planting densities, and under three scenarios of the UAV flight height, obtaining 88.03%, 87.59%, and 87.93% accuracies, which were, respectively, 2.54%, 1.89%, and 2.15% better than the original model. The results of this study showed that the improved YOLOX-m model can achieve UAV orthophoto wheat recognition under different practical scenarios in large fields, and that the best combination were obtained images from the wheat milk stage, low planting density, and low flight altitude.
A New Approach to Develop Resistant Cultivars Against the Plant Pathogens: CRISPR Drives
Authors: Tek Mumin Ibrahim , Budak Kubra
Published: April 2022

CRISPR drive is a recent and robust tool that allows durable genetic manipulation of the pest population like human disease vectors such as malaria vector mosquitos. In recent years, it has been suggested that CRISPR drives can also be used to control plant diseases, pests, and weeds. However, using a CRISPR drive in Arabidopsis for the first time in 2021 has been shown to use this technology in plant breeding to obtain homozygous parental lines. This perspective has proposed using CRISPR drive to develop pathogen-resistant cultivars by disrupting the susceptibility gene (S). In the breeding program, CRISPR is used to create S-gene mutations in two parental lines of hybrid cultivars. However, CRISPR must be reapplied or long-term backcrossed for the parental line to obtain homozygous S-mutant cultivars. When a parental line crosses with different parental lines to develop new hybrids, heterozygous S-mutations could not resist in hybrid against the pathogen. CRISPR drives are theoretically valid to develop homozygous S-mutant plants against pathogens by only routine pollination after CRISPR drive transformation to just one parental line. This way, breeders could use this parental line in different crossing combinations without reapplying the genome-editing technique or backcrossing. Moreover, CRISPR drive also could allow the development of marker-free resistant cultivars with modifications on the drive cassette.
Western Centric Medicine for Covid-19 and Its Contradictions: Can African Alternate Solutions Be the Cure?
Authors: Adunimay Anslem Wongibeh , Ojo Tinuade A.
Published: April 2022

The full impact of COVID-19 is yet to be fully understood, and while there are many unknowns, the rapid and continued reliance on the social media cannot be denied. Some Global Economy and World Health Organisations have discouraged the usage of traditional medicine for COVID-19 treatment. However, some African states such as Tanzania, Equatorial Guinea, Guinea-Bissau, Guinea Conakry, and Togo have engaged with formal researchers to see if traditional medicine can treat COVID-19. Nevertheless, there is still a lot of hesitancy amongst African populations in getting vaccinated. The paper conceptualises the criticism of Western-centric medicine and investigates the promotion of alternate approaches in the African economy. The article situates the study context by exploring the African economy's socio-politics and public health governance. It investigates explicitly African states responses to conventional treatment by analysing the role of traditional medicine and its efficacy as well as the possible effects on the continent. The methodological framework engaged a review approach relying heavily on reputable secondary sources from government publications, journal articles, books and publications from professional bodies and institutional search engines. The data was analysed in themes supporting the study aim's and objectives. The paper concludes that Africa could consolidate the readily available knowledge and give opportunities to traditional medical therapies that are cheap, convenient and safe for public health, especially for COVID-19 supposedly cure.
The Importance of Project Description to Charitable Crowdfunding Success: The Mediating Role of Forwarding Times
Authors: Lu Liangdong , Jiang Weijian , Xu Jia , Wang Fei
Published: April 2022

The COVID-19 outbreak has been a public health crisis of international concern, causing huge impact on people’s lives. As an important part of social public crisis management, how to quickly and effectively raise resources to participate in emergency relief in the era of self-media is a common challenge faced by global charitable organizations. This article attempts to use empirical evidence from Tencent charitable crowdfunding platform, the largest charitable crowdfunding platform in China, to answer this question. We consider 205 COVID-19 charitable projects and 11,177,249 donors to assess the process by which non-profit organizations raise funds through the information about project descriptions. Based on the effects of information and emotional framing, we explore the effects of the readability (i.e., complexity and understandability) and negative tone of the project description on fundraising amount. We then investigate the mediating role of forwarding times, as affective response to the text might explain forwarding times, which in turn affects money raised by increasing the visibility of the campaign. On this basis, the moderating role of recipient’s crisis involvement is tested during this process. The empirical results indicate that the complexity of the description will reduce the fundraising amount, while understandability and negative tone help to improve it. Furthermore, we found that forwarding times played an important mediating role in this process. Then the buffer effect of crisis involvement on the negative effect of complexity was validated, and its amplification on the positive effects of understandability was also verified.
Shared Reality Can Reduce Stressor Reactivity
Authors: Goldring Megan R. , Pinelli Federica , Bolger Niall , Higgins E. Tory
Published: April 2022

When a person faces a stressor alongside someone else, do they get more or less stressed when the other person agrees that the situation is stressful? While an equally stressed partner could plausibly amplify stress by making the situation seem more real and worthy of distress, we find that social validation during co-experienced stressors reduces reactivity. Specifically, the psychological experience of shared reality calms some people down. In Study 1, 70 undergraduate females who jointly faced a stressful event with someone else reported feeling less anxious when the other person felt the same way about the stressor, relative to when the other person appraised the situation in the opposite way or provided no indication of their appraisal. These findings were reflected in participants’ physiological reactivity, especially in the parasympathetic nervous system. In Study 2, we generalize these findings to co-experienced stressors in the daily lives of 102 heteronormative romantic couples in the New York City area. In line with tend-and-befriend theory, we found that shared reality during co-experienced stressors reduced anxiety for almost all females (99% of the sample) and for a minority of males (42% of the sample). Together, these findings unify major theories in health and social psychology by implying that shared reality reduces stressor reactivity, and that this effect is partially moderated by sex.
EEG Microstates in Altered States of Consciousness
Authors: Bréchet Lucie , Michel Christoph M.
Published: April 2022

Conscious experiences unify distinct phenomenological experiences that seem to be continuously evolving. Yet, empirical evidence shows that conscious mental activity is discontinuous and can be parsed into a series of states of thoughts that manifest as discrete spatiotemporal patterns of global neuronal activity lasting for fractions of seconds. EEG measures the brain’s electrical activity with high temporal resolution on the scale of milliseconds and, therefore, might be used to investigate the fast spatiotemporal structure of conscious mental states. Such analyses revealed that the global scalp electric fields during spontaneous mental activity are parceled into blocks of stable topographies that last around 60–120 ms, the so-called EEG microstates. These brain states may be representing the basic building blocks of consciousness, the “atoms of thought.” Altered states of consciousness, such as sleep, anesthesia, meditation, or psychiatric diseases, influence the spatiotemporal dynamics of microstates. In this brief perspective, we suggest that it is possible to examine the underlying characteristics of self-consciousness using this EEG microstates approach. Specifically, we will summarize recent results on EEG microstate alterations in mind-wandering, meditation, sleep and anesthesia, and discuss the functional significance of microstates in altered states of consciousness.
A Mixed-Methods Study on Senior High School EFL Teacher Resilience in China
Authors: Chu Wenxiu , Liu Honggang
Published: April 2022

While teacher resilience has gained significant attention in recent years, empirical exploration of this issue is still insufficient, particularly with regard to English as a foreign language (EFL) teacher resilience in China. In this context, this study employed a mixed-methods design to investigate Chinese EFL teacher resilience. Specifically, the Connor-Davidson Resilience Scale (CD-RISC)-EFL Teacher Survey was distributed to 330 Chinese senior high school EFL teachers. Five volunteers in the survey sample participated in semi-structured interviews. The results revealed that resilience in Chinese senior high school EFL teachers was at a moderate to high level, and there was no significant difference in teacher resilience in relation to gender and years of teaching experience, but a small significant difference with teachers’ educational background. Possible reasons for interpreting EFL teacher resilience were provided from personal and contextual perspectives. Finally, the implications of these findings were discussed for developing teacher resilience.
CEO Relational Leadership and Product Innovation Performance: The Roles of TMT Behavior and Characteristics
Authors: Wang Yimin , Su Qianhong , Sun Wei
Published: April 2022

CEO leadership is considered a critical antecedent of product innovation performance, but the relational aspect of leadership has been largely neglected in this area. Drawing on upper echelons theory and relational leadership literature, this study explores whether, how, and when CEO relational leadership influences product innovation performance. Specifically, we analyze the underlying mechanism of TMT (top management team) voice behavior and two boundary conditions—TMT educational level and TMT age. Based on multi-source and multi-wave data on 105 Chinese firms, this study finds that CEO relational leadership plays an important role in promoting product innovation performance through the intervening mechanism of TMT voice behavior. Furthermore, the positive relationship between CEO relational leadership and TMT voice behavior is stronger in TMTs with higher educational level and lower age. This study contributes to the existing literature by empirically examining the under-investigated relationship between CEO relational leadership and product innovation performance, and by disentangling the underlying mechanism and boundary conditions.
Investment Behavior Related to Automated Machines and Biased Technical Change: Based on Evidence From Listed Manufacturing Companies in China
Authors: Jiang Hong , Wang Xue , Xiao Qian , Li Silin
Published: April 2022

This paper studies the impact of a recent increase in the ratio of automated machines to ordinary capital (RAMOC) on the bias of technical change in the manufacturing industry and the mechanism influencing this. Using panel data of A-share listed manufacturing companies on the Shanghai and Shenzhen stock exchanges from 2012 to 2019, combined with the Xtfrontier model and trans-log production function, we measure the index of the bias of technical change of the manufacturing industry in China. Furthermore, we adopt a fixed effects model to test the impact of an increase of investment in automated machines on the bias of technical change. We also use an intermediary effect model to examine the intermediate mechanism from the perspectives of capital and skill matching. The results show that technical change in the manufacturing industry is biased toward automated machine capital. An incremental increase in RAMOC leads to technical change in the manufacturing industry becoming biased toward automated machine capital, wherein the intermediary mechanism is the labor structure effect. Based on industrial linkage, the investment in automated machines in the upstream (downstream) manufacturing industry increases, the technical change of the downstream (upstream) manufacturing industry is biased toward automated machine capital, and the forward linkage effect is greater than the backward linkage effect. This research enhances understanding of (1) the direction and characteristics of technical change in China, (2) how to improve the output efficiency of automated machines, (3) differences in factor revenue distribution, and (4) how new growth points in the economy can be cultivated. They show that we should encourage and support investment in automated machines, vigorously promote technical change to bias toward automated machine capital, improve the skill level of the labor force, and strengthen the match between automated machines and labor.
Anti-saccade as a Tool to Evaluate Neurocognitive Impairment in Alcohol Use Disorder
Authors: Si Yuqi , Wang Lihui , Zhao Min
Published: April 2022

It has been widely shown that chronic alcohol use leads to cognitive dysfunctions, especially inhibitory control. In an extension of the traditional approach, this research field has benefited from the emergence of innovative measures, among which is an anti-saccade, allowing direct and sensitive measure of the eye movements indexing attention bias to alcohol-related cues and the capability of inhibiting the reflexive saccades to the cues. During the past decade, there are numerous reports showing that drinkers make more unwanted reflexive saccades and longer latency in the anti-saccade task. These increased errors are usually explained by the deficits in inhibitory control. It has been demonstrated that inhibitory control on eye movement may be one of the earliest biomarkers of the onset of alcohol-related cognitive impairments. This review summarizes how an anti-saccade task can be used as a tool to investigate and assess the cognitive dysfunctions and the early detection of relapsing risk of alcohol dependence.
The Impact of Early Neighborhood Cohesion, and Its Mechanism, on Cognitive Function in Later Life
Authors: Zhou Tao , Zhang Xiaoyi , Fan Shuming , Deng Zeming , Jiao Can
Published: April 2022

Objectives

This study aimed to explore the impact of early neighborhood cohesion, and its mechanism, on cognitive function in later life.

Methods

In total, 10,727 Chinese elderly, aged 60–90, forming two datasets (2014 and 2018) from the China Health and Retirement Longitudinal Study (CHARLS) were used as a sample. Childhood neighborhood cohesion was measured by the extent of how much neighbors were willing to help and how close-knit neighbors were. Mini-Mental State Examination (MMSE) and Center for Epidemiologic Studies Depression Scale (CESD-10) were used to assess the cognitive functions and depression of the elderly. We used a structural equation model to examine the relationship between early neighborhood cohesion and late-life cognitive function and conducted bootstrapping analyses to assess the mechanism.

Results

Cognitive function was positively predicted by childhood neighborhood cohesion (β = 0.06, p < 0.001), and cognitive function of the elderly were also positively predicted through the mediating effects of childhood friendships, which included depression and social activity participation as two chain paths.

Conclusion

The findings suggest that childhood neighborhood cohesion positively predicts cognitive function among elderly people through the mediating roles of childhood friendship, depression, and social activity engagement. Childhood neighborhood cohesion is correlated with better childhood friendships, then to fewer depression symptoms and greater elderly social activity participation, and finally to better cognitive functions in the elderly.
mHealth Solutions for Mental Health Screening and Diagnosis: A Review of App User Perspectives Using Sentiment and Thematic Analysis
Authors: Funnell Erin Lucy , Spadaro Benedetta , Martin-Key Nayra , Metcalfe Tim , Bahn Sabine
Published: April 2022

Mental health screening and diagnostic apps can provide an opportunity to reduce strain on mental health services, improve patient well-being, and increase access for underrepresented groups. Despite promise of their acceptability, many mental health apps on the market suffer from high dropout due to a multitude of issues. Understanding user opinions of currently available mental health apps beyond star ratings can provide knowledge which can inform the development of future mental health apps. This study aimed to conduct a review of current apps which offer screening and/or aid diagnosis of mental health conditions on the Apple app store (iOS), Google Play app store (Android), and using the m-health Index and Navigation Database (MIND). In addition, the study aimed to evaluate user experiences of the apps, identify common app features and determine which features are associated with app use discontinuation. The Apple app store, Google Play app store, and MIND were searched. User reviews and associated metadata were then extracted to perform a sentiment and thematic analysis. The final sample included 92 apps. 45.65% (n = 42) of these apps only screened for or diagnosed a single mental health condition and the most commonly assessed mental health condition was depression (38.04%, n = 35). 73.91% (n = 68) of the apps offered additional in-app features to the mental health assessment (e.g., mood tracking). The average user rating for the included apps was 3.70 (SD = 1.63) and just under two-thirds had a rating of four stars or above (65.09%, n = 442). Sentiment analysis revealed that 65.24%, n = 441 of the reviews had a positive sentiment. Ten themes were identified in the thematic analysis, with the most frequently occurring being performance (41.32%, n = 231) and functionality (39.18%, n = 219). In reviews which commented on app use discontinuation, functionality and accessibility in combination were the most frequent barriers to sustained app use (25.33%, n = 19). Despite the majority of user reviews demonstrating a positive sentiment, there are several areas of improvement to be addressed. User reviews can reveal ways to increase performance and functionality. App user reviews are a valuable resource for the development and future improvements of apps designed for mental health diagnosis and screening.
Cognitive Rigidity, Habitual Tendencies, and Obsessive-Compulsive Symptoms: Individual Differences and Compensatory Interactions
Authors: Ramakrishnan Smriti , Robbins Trevor W. , Zmigrod Leor
Published: April 2022

Recent theories have posited a range of cognitive risk factors for obsessive-compulsive disorder (OCD), including cognitive inflexibility and a maladaptive reliance on habits. However, empirical and methodological inconsistencies have obscured the understanding of whether inflexibility and habitual tendencies indeed shape OCD symptoms in clinical and sub-clinical populations, and whether there are notable interactions amongst these traits. The present investigation adopted an interactionist individual differences approach to examine the associations between behaviorally-assessed cognitive flexibility and subclinical OCD symptomatology in a healthy population. It also explored the nature of the interactions between cognitive flexibility and habitual tendencies, and the degree to which these cognitive traits predict subclinical OCD symptomatology. Across two studies, including a preregistration, Bayesian and regression analyses revealed that cognitive inflexibility and compulsive habitual tendencies act as unique and independent predictors of subclinical OCD symptomatology in healthy populations. Furthermore, there was a significant interaction between cognitive rigidity and habitual compulsivity, which accounted for 49.4% of the variance in subclinical OCD symptomatology in Study 1, and 37.3% in Study 2. In-depth analyses revealed a compensatory effect between cognitive inflexibility and habitual compulsivity such that both are necessary for OCD symptomatology, but neither is sufficient. These results imply that in order to generate reliable and nuanced models of the endophenotype of OCD symptomatology, it is essential to account for interactions between psychological traits. Moreover, the present findings have important implications for theories on the cognitive roots of OCD, and potentially in the development of interventions that target both cognitive inflexibility and habitual compulsivity.
Singing at 0.1 Hz as a Resonance Frequency Intervention to Reduce Cardiovascular Stress Reactivity?
Authors: Tanzmeister Sandra , Rominger Christian , Weber Bernhard , Tatschl Josef M. , Schwerdtfeger Andreas R.
Published: April 2022

Slow breathing at 6 breaths per min (corresponding to ~ 0.1 Hz) has been found to benefit psychological and physical health. In this study, we aimed to examine if paced singing at 0.1 Hz has beneficial acute effects on physiological function as compared to slow breathing. Participants were randomized to one of four experimental interventions prior to performing a mental stress task: paced breathing at 0.1 Hz (n = 26), paced singing at 0.1 Hz (n = 26), spontaneous breathing (n = 24), or spontaneous singing (n = 25). Heart rate, heart rate variability in the low (LF-HRV) and high frequency (HF-HRV) domain, blood pressure and affective wellbeing were assessed. As expected, both paced breathing and paced singing resulted in elevated LF-HRV. Moreover, both singing groups evidenced increases in heart rate, blood pressure and positive affect, thus indicating elevated sympathetic activation. Breathing and singing at 0.1 Hz had no robust effect on cardiovascular stress reactivity. Findings suggest that paced singing could constitute a promising alternative to slow paced breathing as it increases cardiovascular coherence, although more studies are needed to elucidate whether slow breathing and/or singing could ameliorate acute stress responses.
Theory of Mind and Empathy in Adults With Epilepsy: A Meta-Analysis
Authors: Wang HongZhou , Zhao PanWen , Zhao Jing , Zhong JianGuo , Pan PingLei , Wang GenDi , Yi ZhongQuan
Published: April 2022

Mounting evidence suggests that social cognitive abilities [including theory of mind (ToM) and empathy] are impaired in adult patients with epilepsy. Although the deficits in overall ToM in epilepsy have been documented well, the effects of epilepsy on empathic ability and specific subcomponents of ToM remain unclear. The primary aim of this study was to provide the first meta-analytic integration of ToM and empathy in adult patients with epilepsy, and to decompose these constructs to clearly differentiate their distinct (cognitive ToM and affective empathy) and overlapping (affective ToM/cognitive empathy) components. This meta-analysis included 28 studies. Adult patients with temporal lobe epilepsy (TLE) and frontal lobe epilepsy (FLE) showed impairments in cognitive ToM and affective ToM/cognitive empathy compared to the healthy controls (HCs); no group differences were identified for affective empathy. Besides, cognitive ToM was impaired in adult patients with idiopathic generalized epilepsy (IGE) and focal seizures (caused by epileptogenic foci) outside the temporal and frontal lobes (extra-TLE/FLE) and no group differences were evident for affective ToM/cognitive empathy compared to the HCs. Moreover, relative to the HCs, no group differences were identified for affective empathy in adult patients with IGE. Additionally, no (statistically) significant difference was observed between the magnitude of ToM/empathy impairment in adult patients who underwent and those who did not undergo epilepsy surgery. These quantitative findings suggest differential impairment of the core aspects of social cognitive processing in adult patients with epilepsy, which may contribute to the development of structured cognitive interventions (i.e., social cognitive training) for adult patients with epilepsy.
Gender Differences in Job Burnout, Career Choice Regret, and Depressive Symptoms Among Chinese Dental Postgraduates: A Cross-Sectional Study
Authors: Yan Li , Zhong Xiaogang , Yang Lu , Long Huiqing , Ji Ping , Jin Xin , Liu Li
Published: April 2022

Background

Job burnout, career choice regret, and depressive symptoms among medical students have received widespread attention. However, little is known about the role of gender in these areas for dental postgraduates. This study aimed to explore gender differences in job burnout, career choice regret, and depressive symptoms among Chinese dental postgraduates.

Methods

The data were collected from an epidemiological survey conducted by our group from February 2021 to March 2021. We used a self-administered questionnaire covering demographic characteristics, the Maslach Burnout Inventory, the Primary Care Evaluation of Mental Disorders scale, and the Career Choice Regret scale. Univariate and multivariable analyses were performed to explore influencing factors.

Results

A total of 558 valid dental postgraduate questionnaires were included in this study. The prevalence of job burnout, career choice regret, and depressive symptoms exceeded 30% in males and females. The prevalence of job burnout was 4.7% higher in females than in males; career choice regret was 12.2% higher in females than in males (P < 0.05), and depressive symptoms were 4.9% higher in females than in males. The multivariable analysis showed that factors associated with job burnout for males were sleep time and career choice regret for females. The influencing factors on career choice regret for females were postgraduate entrance examination score, sleep time, and job burnout. Depressive symptoms were a common influencing factor for job burnout and career choice regret in male and female dental postgraduates. Also, job burnout and depressive symptoms had the highest odds ratio for influencing factors on each other.

Conclusion

Over 30% of dental postgraduates suffered from job burnout, career choice regret, and depressive symptoms, and incidences were higher in females. A discrepancy of influencing factors existed between male and female dental postgraduates. Targeted measures should be taken to change this situation.
Cost-Effectiveness of Avelumab Maintenance Therapy Plus Best Supportive Care vs. Best Supportive Care Alone for Advanced or Metastatic Urothelial Carcinoma
Authors: Xie Qian , Zheng Hanrui , Chen Ye , Peng Xingchen
Published: April 2022

Objective

Avelumab (MSB0010718C) is a fully human anti-programmed cell death ligand 1(PD-L1) antibody against PD-L1 interactions and enhances immune activation against tumor cells in the meantime. Avelumab has been approved for locally advanced or metastatic urothelial cancer (mUC) after disease progression in several countries. We therefore conducted this study to evaluate the cost-effectiveness of avelumab maintenance therapy for advanced or mUC from the perspective of the United States (US) and China payer.

Methods

A Markov simulation model was performed based on clinical trial JAVELIN Bladder 100. Utilities and costs adopted in this analysis were derived from published literature and clinical trials. Incremental cost-effectiveness ratios (ICERs) were calculated to compare the avelumab maintenance therapy group (AVE group) and the best supportive care group (CON group).

Results

The ICER of the AVE group compared with the CON group were $38,369.50 and $16,150.29 per QALYs in the overall population and in the PD-L1–positive population, respectively. While the ICER of AVE group compared with CON group were $241,610.25 and $100,528.29 per QALYs in the overall population and in the PD-L1–positive population, respectively.

Conclusion

Avelumab maintenance therapy was a cost-effective first-line treatment compared with BSC in patients with mUC which were not progressed with platinum-based chemotherapy not only in the PD-L1–positive population but also in the overall population based on the current willingness to pay (WTP) of $150,000 in the US. It was not cost-effective both in the overall population and in the PD-L1 positive population at the WTP threshold of $30,447.09 in China.
At the End of Every Pandemic: Beginning a Pandemic Playbook to Respond to the Next
Authors: Goldschmidt Peter G.
Published: April 2022

The world was unprepared for COVID-19. Pandemics can unfold quickly; faster than governments can respond, unless they have maintained a realistic pandemic playbook. As the world ahead becomes ever-more complex, such playbook becomes ever-more necessary. This article not only describes the importance of a pandemic playbook but also a system to maintain it. A pandemic playbook both (1) specifies what is needed to respond to a pandemic and (2) provides a lens through which to identify measures that will keep people safe and society secure. The plays in the book are thought-though policies and strategies and corresponding implementation plans. The process of developing a playbook is as important as the product. Any playbook must be fit for purpose in the context of the times in which it is to be used. Above all, it must contain realistic policies and plans that can actually be implemented and can realize their intended effects. Achieving this goal requires (1) repeatedly exercising the playbook so that people know what to do when they need to do it and (2) evaluating results and updating the playbook to keep it relevant and current. Necessarily, to bring ideas alive, this article illustrates them with reference to COVID-19 and earlier pandemics, but it is not intended as a playbook for responding to the next pandemic; nor a postmortem on responses to COVID-19. Instead, it describes actions to take now to be ready when the next global pandemic strikes, so that policy decision-makers will not be lamenting “we should have done that.”
Occupational Burnout Symptoms and Its Relationship With Workload and Fear of the SARS-CoV-2 Pandemic Among Hospital Nurses
Authors: Belji Kangarlou Marzieh , Fatemi Farin , Paknazar Fatemeh , Dehdashti Alireza
Published: April 2022

Introduction

The pandemic has intensified physical and psychological work demands experienced by nurses in a hospital environment. The purpose of this study was to examine personal and work environmental risk factors associated with occupational burnout among hospital nurses.

Methods

We conducted a cross-sectional from April to November 2020. Data from 831 nurses who worked professionally in four educational hospitals were compiled through survey questionnaires to report the prevalence of burnout, occupational and individual factors. Independent t-test and Mann–Whitney test measured the link between the scopes of occupational burnout and risk factors.

Results

About half of the participants indicated moderate symptoms of burnout. The fear of the nurses correlated significantly with emotional exhaustion (r = 0.71, p = 0.001), depersonalization (r = 0.67, p = 0.02), and personal accomplishment (r = 0.63, p = 0.05). Mental demand (r = 0.74, p = 0.01) and effort at work (r = 0.68, 0.001) correlated significantly with emotional exhaustion (r = 0.51, p = 0.03).

Conclusion

The findings indicated a high prevalence of burnout symptoms, particularly emotional exhaustion, among hospital nursing professionals. Occupational health services should consider burnout as an occupational-related condition and provide interventions to reduce workplace chronic stressors and burnout in hospitals.
The Moderating Effect of Community Environment on the Association Between Social Support and Chinese Older Adults' Health: An Empirical Analysis Study
Authors: Li Dongfang , Li Xiaolin , Zeng Yi
Published: April 2022

Background

The aging population conundrum and the gradual weakening of older adults' health and ability to obtain resources as they age have drawn attention to this population's health. Older adults' health relates not only to their own quality of life, but also to the development of families/society.

Methods

We analyzed micro data from the 2011 and 2015 waves of the China Health and Retirement Longitudinal Study Follow-up Questionnaire, using the probit model, ordinary least squares model, and other methods.

Results and Conclusions

Both formal and informal social support significantly impacted the physical and mental health of Chinese older adults, and the community environment moderated this relationship. To build a reasonable and effective social support system for older adults and improve their health, we suggest that stakeholders should continue to strengthen the formal and informal social support provided to older adults; they should also build a community-based care system, which will allow for the moderating role of community environment on the relationship between social support and older adults' health. Family and social support factors are important for older adults' health. We should enable the moderating role of community environment on the relationship between social support and health to be fully exerted, as well as build a community-based pension system.
Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly
Authors: Shive Carey , Pandiyan Pushpa
Published: April 2022

An optimal immune response requires the appropriate interaction between the innate and the adaptive arms of the immune system as well as a proper balance of activation and regulation. After decades of life, the aging immune system is continuously exposed to immune stressors and inflammatory assaults that lead to immune senescence. In this review, we will discuss inflammaging in the elderly, specifically concentrating on IL-6 and IL-1b in the context of T lymphocytes, and how inflammation is related to mortality and morbidities, specifically cardiovascular disease and cancer. Although a number of studies suggests that the anti-inflammatory cytokine TGF-b is elevated in the elderly, heightened inflammation persists. Thus, the regulation of the immune response and the ability to return the immune system to homeostasis is also important. Therefore, we will discuss cellular alterations in aging, concentrating on senescent T cells and CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) in aging
Effect of Fatiguing Wheelchair Propulsion and Weight Relief Lifts on Subacromial Space in Wheelchair Users
Authors: Arnet Ursina , Boninger Michael L. , Cools Ann , Bossuyt Fransiska M.
Published: April 2022

Objective

This study aimed to identify targets of intervention for reducing shoulder pain in wheelchair users with spinal cord injury (SCI) by (1) examining changes in subacromial space [acromiohumeral distance (AHD) and occupation ratio (OccRatio)] with fatiguing wheelchair propulsion, and different loading conditions [unloaded position vs. weight relief lifts (WRL)]; (2) associating these changes with wheelchair user capacity, as well as (3) identifying subject characteristics associated with subacromial space, such as sex, lesion level, time since injury, body mass index and impaired shoulder range of motion.

Methods

Fifty manual wheelchair users with SCI [11 females, age = 50.5 (9.7) years, time since injury = 26.2 (11.4) years] participated in this quasi-experimental one-group pretest-posttest study. Ultrasound images were used to define AHD during an unloaded position, and during personal and instructed WRL before and after fatiguing wheelchair propulsion. Furthermore, supraspinatus and biceps thickness defined from ultrasound images were used to calculate OccRatios. Wheelchair user capacity was quantified as functional strength (maximum resultant force reached during maximum isometric forward push) and anaerobic work capacity (highest power output reached during 15-m sprint test). Multilevel mixed-effects linear regression analyses controlling for between subject variability and covariables were performed to address the research questions.

Results

AHD was significantly smaller during personal WRL (p < 0.001) and instructed WRL (p = 0.009, AHD both 11.5 mm) compared to the unloaded position (11.9 mm). A higher wheelchair user capacity (higher anaerobic work capacity) reduced the impact of WRL on AHD decrease. The fatiguing wheelchair propulsion had no effect on AHD (p = 0.570) and on OccRatio of supraspinatus (p = 0.404) and biceps (p = 0.448). Subject characteristics related to a larger subacromial space were lower lesion level, shorter time since injury, impaired external rotation, a lower body mass index and a higher anaerobic work capacity.

Conclusion

This study showed a significant reduction in AHD during WRL with no effect of fatiguing wheelchair propulsion on the subacromial space in wheelchair users with SCI. A higher anaerobic work capacity was beneficial in stabilizing the shoulder during WRL. Our findings may assist clinicians in designing a shoulder injury prevention program.
Effectiveness of the Lorodent Probiotic Lozenge in Reducing Plaque and Streptococcus mutans Levels in Orthodontic Patients: A Double-Blind Randomized Control Trial
Authors: Ebrahim Fatima , Malek Sarah , James Kris , MacDonald Kyle , Cadieux Peter , Burton Jeremy , Cioffi Iacopo , Lévesque Celine , Gong Siew-Ging
Published: April 2022

Orthodontic patients are at a significant risk for oral diseases due to increased plaque accumulation and oral bacterial dysbiosis. We aimed to determine the efficacy of the commercially available Lorodent Probiotic Complex at reducing plaque accumulation and Streptococcus mutans bacterial levels in adolescent orthodontic patients. Sixty adolescents undergoing fixed orthodontic treatment for a minimum of 6 months were recruited in a randomized, double-blind, parallel-group, placebo-controlled trial. They received either Lorodent probiotic lozenge (intervention, n = 30) or placebo lozenge (control, n = 30) orally every day for a 28-day administration period. Participants were assessed at four appointments (T1–T4) over a total of 56 days. Compliance and lozenge satisfaction were monitored. Saliva samples and supragingival plaques were collected for evaluation of S. mutans levels. Clinical assessment using a Plaque Index (PI) was used. Compliance with lozenge intake of all participants was over 90%. There was no significant change in the PI and composite PI scores in both placebo and probiotic groups at each time frame (all p > 0.05) or the relative S. mutans DNA levels in the saliva and plaque between the probiotic and placebo groups. The findings of high compliance and satisfaction with the probiotic lozenges combined with the study's rigorous design offer a baseline for subsequent testing of further potential probiotics (of varying formulations, concentrations), especially in adolescents.