bluuebunny/crossref_metadata_2025 huggingface dataset:
Radon in child care centers: An examination of state laws and regulations in the United States
Authors: Benjamin Poku  , Sayed Hussaini
Published: June 2021

Radon is the second leading cause of lung cancer after smoking in the United States (US); however, there is a lack of state policies and regulations to address radon gas exposure. This study aimed to explain if state radon legislation for child care centers is associated with the percent of counties within the state in radon zone 1(above 4 pCi/L). The research method was secondary analysis. Data were obtained from EPA radon website, journal resources, state laws and regulations, and official state government websites. The existing radon laws were assessed based on the EPA radon zones. Then, independent T-Test with a significant level of P<0.05 was used. The finding of this study indicated 39 US states have at least one county or more in radon zone 1, and 11 states have no counties in radon zone 1. Eleven states have legislation associated with child care centers, and 39 states have no such regulation in place. Twenty eight percent (28%) (n=39) of states with at least one county or more in radon zone 1 have radon regulations for child care facilities. The findings reveal that states located in EPA radon zone 1, partially or completely, were Eighty eight percent (88%) likely to not have different regulations requiring the radon testing in child care centers than states that are not in zone 1. In other words, the association between state radon legislation for child care centers and the percent of counties in radon zone 1 is remarkable but not significant (p-value = 0.12).
Representaciones femeninas en la configuración de la memoria de Atenas (s. vi a.C.)
Authors: Rodríguez David Sierra
Published: June 2021

La documentación que aquí presentamos se compone de tres representaciones figurativas femeninas que, halladas en el área de la Acrópolis de Atenas, cuentan con un espectro cronológico que abarca parte de la primera y toda la segunda mitad del siglo vi a.C., esto es, el período inmediatamente posterior al arcontado de Solón y, sobre todo, el de los sucesivos gobiernos tiránicos, que culminaría en las reformas clisténicas. Los tres ejemplos se custodian actualmente en el Museo Arqueológico Nacional de Grecia y en el Museo de la Acrópolis de Atenas y, si bien existe diversidad de opiniones, aquí nos sumaremos a la hipótesis de que representan a Pándroso, Aglauro y quizás Herse, las hijas del primer rey mítico de Atenas, Cécrope.
Margarita Leclerc, la revista Concepción Arenal y el feminismo en España (1927-1931)
Authors: Feron David Ginard
Published: June 2021

Teresa Herrero Ruiz (1897-1966), “Margarita Leclerc” es, sin duda, una de las escritoras feministas españolas anteriores a la Segunda República que han pasado más desapercibidas. A finales de la década de los años veinte encabezó desde Barcelona y Mallorca algunas originales iniciativas en pro de la liberación de la mujer, como la edición de un impactante ensayo sobre la superioridad femenina y de la revista Concepción Arenal, consagrada parcialmente a divulgar la figura de la pionera del feminismo español. Su aislamiento respecto a las principales redes organizativas, el misterio en torno a su identidad y la muerte, en 1932, de su polémico mentor José A. Ruiz Rodríguez Méndez, “Max Bembo”, explican la desaparición de Leclerc de la escena pública, así como la nula repercusión de su obra en los años republicanos y el olvido de que ha sido objeto por la historiografía feminista española.
PROPAGAÇÃO DE FALSA-MIRRA POR MINIESTAQUIA DE DIFERENTES PORÇÕES DO RAMO E TIPOS DE CORTE
Authors: Pinheiro Marcos Vinicius Marques , Schmidt Denise , Thiesen Leonardo Antonio , Junges Diéssica Letícia , Diel Maria Inês , Holz Evandro , Mariotto Axel Bruno
Published: June 2021

A planta medicinal Tetradenia riparia pode ser propagada vegetativamente, no entanto, não há relatos do emprego da técnica de miniestaquia provenientes de diferentes porções do ramo e do tipo de corte para propagação desta planta. Com isso, o objetivo deste trabalho foi avaliar a produção de mudas a partir de miniestacas provenientes de diferentes porções do ramo e com diferentes tipos de corte apical. O experimento foi conduzido em delineamento de blocos casualisados, constituído de seis tratamentos [miniestaca proveniente da porção apical em corte reto (T1) e em bisel (T2); miniestacas da porção mediana em corte reto (T3) e em bisel (T4); miniestacas da porção basal em corte reto (T5) e em bisel (T6)] e quatro repetições cada. Após 60 dias, avaliaram-se: número de folhas, número de brotos, comprimento de brotos, massa fresca e massa seca de raiz e da parte aérea e o somatório de enraizamento. Observou-se que as miniestacas em T2 apresentaram os melhores resultados com relação às variáveis analisadas. As miniestacas medianas e da base apresentaram resultados inferiores, e o tipo de corte apresentou influência na propagação das miniestacas. Assim, Tetradenia riparia pode ser propagada vegetativamente por miniestaquia provenientes do ápice dos ramos com corte em bisel.
ANÁLISE SISTEMÁTICA DAS RESPOSTAS METABÓLICAS DA MICROBIOTA SOB APLICAÇÃO DE HERBICIDAS PRE-EMERGENTES EM SOLOS TROPICAIS
Authors: Pessoa-de-Souza Marco Aurélio , Gonçalves Liliane Mendes , E Barros Marilda da Conceição Ribeiro , De Miranda Larissa Gonçalves , Schindel Nathaza Yohana Amorim
Published: June 2021

O excesso de aplicação de agrotóxicos é motivado pela expansão de complexos agrícolas, como a cana-de-açúcar. Dentre os produtos mais usados, o clomazone, o hexazinone e o imazapic ganham destaque. Sabe-se que o comportamento de herbicidas no solo é dependente de características físico-químicas das moléculas e do solo, e a biodisponibilidade impacta diretamente na biodiversidade do solo. Portanto, o objetivo deste estudo foi fazer uma revisão sistemática e crítica em torno das similaridades metabólicas do mecanismo de ação dos produtos e das rotas bioquímicas de microrganismos de solo. As evidencias apontaram para similaridades que podem afetar negativamente e positivamente a microbiota do solo, existe um consenso da versatilidade do grupo das Pseudomonas sp. nos processos de degradação.
LICURI BAGASSE (SYAGRUS CORONATA) IN RATIONS FOR BROILERS
Authors: Melo Fúlvio Viegas Santos Teixeira de , Da Cruz Neto Manoel Adriano , Mendes Damião Bonfim , Melo Jose Fernando Bibiano
Published: June 2021

The evaluation of the use of licuri bran for broilers in the initial (1-21 days), growth (22-35 days) and finishing (36-42 days) phases. Three hundred birds with a day age were submitted to four treatments with diets based on corn and soybean containing levels of inclusion of the licuri bagasse (4, 8, 12 and 16%) and a reference diet without the inclusion of the bagasse. Daily weight gain (DWG), total weight gain (TWG), daily feed intake (DFI) and feed conversion (FC) were evaluated. A completely randomized design was used. Five treatments and six replicates, with a density of 10 birds / m2 per experimental unit. Regression analysis was performed. The inclusion of increasing licuri bagasse levels interfered positively in the of birds’ performance, providing better rates for the levels with 8; 12 and 16% inclusion of the bran, within the studied variables.
GEOTECNOLOGIAS APLICADAS A AQUICULTURA: ESTUDO DE CASO DO POTENCIAL AQUÍCOLA DO MUNICÍPIO DE CONCEIÇÃO DO ARAGUAIA-PA.
Authors: Catuxo Victor Tiago Da Silva , Costa Breno Gustavo Bezerra , Silva Kátia Cristina De Araújo
Published: June 2021

O presente estudo no município de Conceição do Araguaia no estado do Pará visando observar de forma espacial o estabelecimento de empreendimentos aquícolas e a possibilidade de ampliação da atividade, utilizando análise espacial ponderada. Foi verificado a distribuição espacial dos piscicultores existentes e suas respectivas produções, através de ferramentas geoestatísticas, entre as quais: Averagem Nearest Neighbor (ANN) e kernel, para análise de densidade e o método Natural Neighbor (NN) para avaliar as áreas mais produtivas. Para análise de ponderação a áreas propícias a construção de viveiros escavados utilizou a metodologia Weighted Overlay, que sobrepõem várias camadas com pesos atribuídos, de acordo com a sua participação no processo construção aquícola. Na análise de ponderação foram utilizadas imagens de satélite processadas de forma a representar relevos, hidrografia e uso do solo, em alguns mapas foi utilizado informações de instituições governamentais. Os resultados mostraram que a dispersão dos piscicultores se deu de forma agregada. Os aglomerados formados dentro de um raio de 5,0 km, constituíram 6 áreas, mas apenas duas com potencial para crescimento. As ponderações de áreas propicias, mostraram que 27,43% é regular e 16,65% são ideais, muito embora a atividade se desenvolveu nas áreas regulares.
GERMINAÇÃO E DESENVOLVIMENTO DE SEMENTES DE DOIS HÍBRIDOS DE MILHO SOB ESTRESSE HÍDRICO.
Authors: Ribeiro Crosa Claudia Farela , Chacón-Ortiz Andrés , Felipez Winder
Published: June 2021

O milho é uma cultura altamente sensível às deficiências hídricas sofridas por as mudanças climáticas súbitas e inesperadas dos últimos anos. É por isso que se avaliou o efeito do potencial osmótico (PO) na germinação e crescimento de plântulas de dois híbridos de milho (BM709 e Milho Doce 159-cat S2). Um DIC foi usado com um arranjo bifatorial com 2 níveis de variedades e 6 níveis de potencial osmótico com 2 repetições. O PO: 0; -0,2; -0,4; -0,6; -0,8 e -1,0 Mpa foram usados. A tendência de ambos os híbridos foi diminuir seu potencial de crescimento tanto na raiz quanto no nível da parte aérea em -0,4 MPa. Apesar de observar graficamente uma menor capacidade de resposta da variedade 1 v.s. da variedade 2, não foram encontradas diferenças significativas quando elas foram comparadas as duas variedades versus os potenciais osmóticos, porém, apresentam-se diferenças significativas na capacidade germinativa de cada uma.
„A beach resort for people who don’t like beach resorts“. Die idyllische Ambivalenz des Strandes: Danny Boyles The Beach als filmisches Ausstiegsnarrativ
Authors: Jablonski Nils
Published: June 2021

The idyllic setting of Danny Boyle’s film The Beach presents this place as a space of longing and escape – longing for the return to a more natural, idealized way of life and escape from everyday life. Even as the film draws upon the paradigm of the idyll in its depiction of the beach, it simultaneously deconstructs any notion of a habitable paradise on Earth. Using semiotic theories of space, this article examines the ambivalence of modern tourist desires. The film shows how the continuous narrativization of an idyllic space becomes the impetus for a community of backpackers to risk their lives for illusory ideals which cannot be upheld in reality.
Off the grid. Touristische Idyllen der Entnetzung
Authors: Schabacher Gabriele
Published: June 2021

The article examines the relation of tourism and idyll in regard to the mediation of the tourist experience. Digital detox tourism and off grid tourism are two examples of contemporary tourism – including their respective practices and ways of promotion – that associate certain cultural stereotypes with the idyll. While digital detox tourism promises independence from the digital world, off grid tourism detaches the tourist from infrastructure and supplies. Paradoxically, the advertising of these types of ‘disconnection’ makes use of the same linked infrastructures that tourists are bound to leave behind. Thus, this article reveals the ways in which digital detox tourism and off grid tourism remain dependent on those networks.
Drug interactions in the pharmacotherapy of patients included in primary care comprehensive medication management services
Authors: SILVA Hágabo M. , RAMALHO-DE-OLIVEIRA Djenane , MARTINS Ursula M. , NASCIMENTO Yone A. , REIS Adriano M. , SANTOS Aline A. , NASCIMENTO Mariana  G.
Published: June 2021

Objective: A drug interaction (DI) is the clinical event in which the effect or action of one drug is modified by the presence of another. Because of potential harms and low consistency of available information, it is critical to assess the clinical relevance of DI. This study aimed to identify and evaluate the clinical consequences of DI in the pharmacotherapy of patients followed in a primary care Comprehensive Medication Management (CMM) services. Methods: This observational cross-sectional study was based on the analysis of the CMM records all the patients that used at least two medications and attended to at least three CMM consultations from August 2015 to March 2016 (n=88). Potential DI were identified among the medications used in the initial consultation of CMM using Micromedex® Drug-Reax® software. The DI were classified as “monitorable” (when its clinical consequences could be monitored by effectiveness or safety paremeters) or non-monitorable, and their clinical consequences were evaluated by analysis of CMM records. Results: Among the studied population 95.5% of the patients had at least one potential DI in their pharmacotherapy, totaling 493 potential DI. Of all the potential DIs identified, 90.9% were monitorable, and the majority of these monitorable DI presented no clinical consequences (62.7%). For 63.9% of the DI with clinical impact, the pharmacist adopted direct or indirect measures that would favor the resolution or reduction of the clinical impact of DIs. Conclusion: The CMM service facilitates the management of DIs since its decision-making method calls for monitoring of the effectiveness and safety parameters, individualizing the management of DIs according to the patient’s needs and their clinical consequences.
COMPARATIVE ANALYSIS OF METHODS FOR DETERMINATION OF SUPPLY FLOWS
Authors: Semchenko Nataliia , Kholodova Olha , Buhaiova Maryna
Published: June 2021

Problem. The capacity of signalized intersections is determined using the concept of "saturation flow". It is the main characteristic in the process of their analysis, design and calculation. The work is devoted to solving the scientific-applied problem of increasing the efficiency of the signalized intersection at one level by choosing a rational method of determining saturation flows for these characteristics of traffic flows, geometric parameters of the intersection and infrastructure in its area. The subject of the study is the influence of the main characteristics of the traffic flow, parameters and infrastructure of the intersection on the saturation flow value. Goal. The aim of the work is the analysis of the influence of the main characteristics of the traffic flow, parameters and infrastructure of the intersection on the saturation flow value. Methodology. The calculation of the control regime at the intersection is based on determining the relation between the traffic intensity of vehicles at the intersection and the saturation flow value, which changes under the influence of a number of factors. Analytical calculation of the saturation flow value is based on using of correction factors that take into account the influence of these factors. Results. The methods of determination of saturation flows are analyzed out in the work; performed a comparative analysis of the definition of ideal saturation flows by different methods; a comparative analysis of the determination of the saturation flow correction coefficients for the parameters that have an effect on it were performed; the estimation of discrepancy at calculations of coefficients of correction of saturation flows by various methods is done; the list of coefficients which need to be considered at definition of their influence on a saturation flow is refined. Originality. In oppose to classical and other approaches to determining the saturation flow, the method recommended by the American "Highway Capacity Manual" takes into account more parameters of influence. It is proposed to use this method for the saturation flow calculation, but with an updated list of coefficients that must be taken into account in the calculations. Practical value. The results of the work can be used in the practice of improving the efficiency of signalized intersections in sections of the urban road network, as well as in further research on this topic.
INFLUENCE OF THE MEASURING TOOLS ON THE FLOW CHARACTERISTICS IN VORTEX CHAMBER PUMP
Authors: Rogovyi Andrii , Neskorozhenyi Artem
Published: June 2021

Problem. Perturbation of the flow by measuring instruments forces researchers to choose optical research methods. But these methods significantly increase the cost of experimental research, due to the high cost of optical-type measuring equipment. On the other hand, using contact methods for measuring the flow velocity, such as Pitot tubes, hot-wire anemometers, the researcher must be sure that the measurement results can really be compared with the calculations results and the equipment influence on the flow parameters is minimal. The aim of this work is to study the measuring tool influence on the flow characteristics in the swirl chamber pump, as well as to compare the results obtained due to the measurements with the parameters of the undisturbed flow. The research methodology consisted of two stages: 1) modeling the flow in the model pump; 2) comparison of flow characteristics, as well as the values of velocity and pressure at the points of installation of the measuring tool. Results. Although the total velocity at the measuring point is practically independent of the measuring tool, the tangential component of the velocity is significantly reduced. It indicates that there is a significant error in velocity measuring. For a more accurate rotational velocity component measurement, it is necessary to orient the instrument perpendicular to the measured component. Scientific novelty. Installing the measuring tool in the end cover of the swirl chamber reduces the flow rate sucked by the pump through the lower axial channel. The size of the tool has practically no effect on the energy characteristics of the swirl chamber pump. Practical value. To ensure measurement accuracy, the ratio of the swirl chamber dimensions and the tool should be ensured in the way that the relative diameter of the tool does not exceed 0.25 of the swirl chamber neck diameter.
Comparative evaluation of dynamics and fuel efficiency indicators of the car with robotic stepped transmission under condition of different diameters of engine cylinders
Authors: Hudz Hustav , Нlobchak Mykhailo , Pelo Roman , Kotsjumbas Oleg
Published: June 2021

Problem. Repair dimensions method regulates increment of cylinders by the means of mechanical treatment, which leads to increasing of working volume of the engine. This will cause a change of dynamics and fuel-efficiensy indicators of the car with the certain type of transmission. Goal. The goal is to comparatively evaluate dynamism and fuel-efficiency of automotive vehicle category N2 with two options of engines, which have nominal and repair cylinder sizes. The riding cycle of the cars with robotic stepped gearbox was researched, that is without breaking of force stream while switching gears. Methology. Imitative simulation of cars riding cycle, according to standard, was conducted with the help of Matlab Simulink software. Because of the fact that mathematical model of cars movement during mentioned cycle is based on elementary dependencies, for its realization the only basics avialable blocks of the sofware package were used. The flowchart is given in the paper. Results. Simulation of riding cycle of N2 – category automotive vehicle with robotic gearbox was conducted at full engine’s capacity while running-up. Obtained results have shown that engines with repairment sizes have advantage in dynamism indicators, engines with nominal cylinder sizes have advantages in fuel-efficiency. Originality. For obtaining of comparative evaluation of dynamics and fuel-efficiency indicators of the car with robotic gearbox with different engines, the imitation simulation of riding cycle, according to standarts, was used with the help of Matlab Simulink software. Practical value. Application of the repairment sizes method upon the engine’s cylinder liners has shown improvement of dynamics indicators of car with robotic transmission, which will improve its productivity under excessive engines work conditions.
Evaluating traffic parameters of vehicles according to registrars when conducting automotive research
Authors: Yalovenko Vladyslav , Danets Serhii
Published: June 2021

The main tendencies in developing the methods of evaluating vehicles movement according to registrars when conducting automotive research of road accidents are considered. It is noted that modern video recorders, in addition to the standard recording of events in the form of video, have additional functions of recording the parameters of traffic, which allows more objective and in-depth investigation of the circumstances of road accidents. Goal. The aim of the work is development of the method of obtaining quantitative data that allow to estimate the parameters of vehicle movement on video recordings made with the help of DVR MiVue-j85. Methodology. Theoretical data of the functionality of the MiVue-j85 video recorder were verified and analyzed during the real experiment. The study includes an analysis of quantitative data to assess the parameters of vehicle movement on video recordings made using a video recorder MiVue-j85. Results. It is noted that this method currently has a number of disadvantages, which are the imperfect system of synchronization, display and recording of the received data using software designed for the DVR. The presence of integrated in the DVR GPS-navigation and G-sensor, make it possible to determine the parameters of the vehicle and the coordinates of the location of the vehicle in the process of changing its dynamics, but with a significant error that does not meet the requirements of accident research. Originality. For the first time, the method of obtaining vehicle motion parameters using a video recorder with a built-in G-sensor is shown. Practical value. The obtained results can be used in practice in the study of the circumstances of the accident. Application of the certain method will allow facilitating the process of reception of initial data, namely the parameters of vehicle movement when studying road accidents.
Promoting Multilingual Students’ Disciplinary and Language Learning Through the WIDA Framework for Equitable Instruction
Authors: Molle Daniella , Wilfrid Jennifer
Published: June 2021

This article explores the development of a guidance document titled the “Framework for Equitable Instruction” (Framework), which aims to support multilingual students’ content-area learning and language development. The Framework was developed by WIDA, a national consortium of states, as part of its system of language standards, assessments, and professional learning. The article discusses the Framework using a protocol originally created for the alignment of content-area and language standards. The protocol highlights the rigorous theoretical foundations of the Framework, the research-based rationale behind its conceptualization of language trajectories, and the tight linkages between the Framework, content-area standards, and classroom instruction. The systematic exploration of the Framework’s features in this article can inform the future design of language standards and related documents and serve as a foundation for the constructive critique of existing ones.
Multi-Level Conditional Transit Signal Priority in Connected Vehicle Environments
Authors: Cvijovic Zorica , Zlatkovic Milan , Stevanovic Aleksandar , Song Yu
Published: June 2021

Connected Vehicles (CV) are an emerging technology with a large potential to improve traffic operations and safety. This paper develops and tests advanced CV-based multi-level conditional Transit Signal Priority (TSP). The algorithms are using the latitude/longitude (lat/lon) coordinates of CV vehicles and intersections to establish communication, share information and request priority. The TSP strategies are implemented through controllers’ built-in features and logic processor, using Econolite ASC/3 as a representative traffic signal controller. The tests were performed in VISSIM microsimulation with the ASC/3 Software-in-the-Loop (SIL) controller emulator. State Street in Salt Lake City, UT, is selected as a test-case corridor. The paper shows that the developed signal control priority (SCP) algorithms are successful in reducing delays for target vehicles in excess of 6%, without significant impacts on other traffic. The information obtained from CV vehicles can be used to further enhance control algorithms and create adaptive SCP programs.
Overview of methods of application of waste car tires in the production of asphalt mixtures and the possibility of application in Montenegro
Authors: Božović Ivan , Mirković Katarina
Published: June 2021

The use of waste car tires in the production of asphalt mixtures has been used successfully for over 50 years around the world, starting with the USA, Australia, South Africa, many European countries, and progress in this area can be found in the region, especially Hungary. The aim of this paper is to get familiar with the methods of application of waste car tires in the production of asphalt mixtures that are used in the world, introduction to the basic terms, equipment and machinery necessary for production, construction and testing of mixtures, and analysis of basic conditions for possible application in Montenegro.
Roundabouts - drivers' attitudes about the way of moving in two-lane roundabouts
Authors: Gnjatović Nikola
Published: June 2021

In the last few years, there has been an expansion in the construction of roundaboust. The construction of roundabouts, raised the level of traffic safety. However, it can not be said that all roundabouts have the same level of traffic safety. One-lane roundabouts belong to the category of roundabouts with the fewest points of conflict, and then follow two-lane and multi-lane roundabouts. In general, in the Republic of Srpska there are certain deficiency in the statute and regulations, which refer to this area. These deficiency bring drivers to misapprehension how they should behave at roundabouts. In this labour will be presented the data obtained by surveying with random sampling. Attitudes refer to the way of direction of drivers, only in two-lane roundabouts. Also, in the labour we will provide a suggestion of measures. The suggested measures are practical and can be relatively easily applied in our country.
Increasing the level of traffic safety - the role of standardization in the field of vehicle control and testing in Serbia
Authors: Božanić Vojislav , Dedovic Vlastimir , Božović Milan
Published: June 2021

The paper presents an overview of the most important regulations and institutions affecting the level of quality and fittingness of the vehicle fleet, in order to increase the level of general traffic safety in the Republic of Serbia. The Traffic Safety Agency, among other things, alone or in cooperation with others, regulates, controls and implements the system of homologation, testing and control of conformity of vehicles, equipment and parts. It authorizes and supervises other organizations for vehicle control and testing. The role of standardization in this process is dual: first - it refers to the subject of testing - vehicles, and second - to the quality of testing - authorized organizations. The paper discusses the important provisions of regulations for vehicle testing and analyzes the impact of the standards ISO 17020 and ISO 17025 on the work of authorized organizations. In conclusion, it was proposed that in order to achieve and maintain high level of testing quality, mandatory accreditation of authorized organizations should be prescribed. Mandatory application of the standards would have a positive impact on the traffic safety segment which depends on the technical characteristics of the vehicle, and as well, reduce the Agency's obligations.
Warisan Cagar Budaya sebagai Ikon Desa Wisata Kaba-Kaba, Kabupaten Tabanan, Bali
Authors: Darma Oka I Made , Sudiarta Made , Widya Darmayanti Putu
Published: June 2021

Kini semakin banyak desa di Bali menggali potensi desanya agar mampu bersaing secara kompetitif guna mendapatkan manfaat dari aktivitas pariwisata. Salah satu desa yang sedang berbenah untuk mengembangkan desa wisata yaitu Desa Kaba-Kaba. Artikel ini bertujuan untuk mengkaji keberadaan warisan â€œcagar budayaâ€ dalam pengembangan Desa Wisata Kaba-Kaba. Pengumpulan data dilakukan dengan metode observasi, wawancara, dan studi pustaka dengan analisis deskriptif kualitatif. Hasil penelitian menunjukkan bahwa Desa Kaba-Kaba mengusung cagar budaya sebagai ikon atau ciri khas dari pengembangan desa wisata yang disinergikan dengan keasrian alam persawahan sebagai paket wisata cycling unggulan. Pengangkatan warisan â€œcagar budayaâ€ sebagai ikon Desa Wisata Kaba-Kaba menunjukkan bahwa kesadaran masyarakat akan pelestarikan warisan budaya semakin kuat guna mendukung implementasi Perda Provinsi Bali No.4/2014. Masyarakat lokal antusias mendukung hal tersebut agar pengembangan pariwisata di desanya dapat berkelanjutan. Disarankan kepada pemerintah harus tetap memantau eksistensi warisan â€œcagar budayaâ€ agar tetap ajeg dan lestari di masa depan.
Eksistensi Kesenian Rebana Gending Desa Langko Dalam Masa Pandemik Covid-19 Di Lombok
Authors: Yudarta I Gede , Haryanto Tri
Published: June 2021

Tulisan bertujuan untuk mengungkap eksistensi kesenian Rebana Gending yang merupakan salah satu bentuk musik tradisional Sasak, Lombok. Merebaknya pandemic Corona Virus Disease (Covid) 19 pada tahun 2019 dan mengalami perkembangan di Indonesia pada awal tahun 2020, sangat berdampak dalam berbagai aspek kehidupan termasuk salah satunya di bidang budaya. Kesenian sebagai salah satu aspek kebudayaan mengalami stagnasi dimana banyak aktivitas berkesenian dibekukan sehingga berdampak secara negatif terhadap eksistensi berbagai bentuk kesenian yang terdapat di masyarakat. Fenomena ini juga terjadi pada eksistensi kesenian Rebana Gending yang terdapat di Desa Langko, Kecamatan Lingsar, Kabupaten Lombok Barat, Nusa Tenggara Barat. Rabana Gending merupakan salah satu bentuk kesenian tradisional yang hidup dan berkembang di dalam masyarakat Sasak. Kesenian ini memiliki berbagai keunikan dalam bentuk, fungsi dan musikalitas sehingga berbeda dengan kesenian rebana yang secara umum berkembang di berbagai wilayah di Indonesia. Berkenaan dengan berbagai keunikan tersebut, topik yang dikaji secara khusus akan membahas bentuk dan fungsi kesenian Rebana Gending di dalam kehidupan masyarakat di Lombok. Adapun metode yang digunakan adalah metode kualitatif dengan pendekatan organologi dan ethnomusikologi. Dari pembahasan topik ini selanjutkan akan diketahui dan dipahami bentuk dan fungsi kesenian Rebana Gending di dalam kehidupan masyarakat Sasak.
Stimulator of interferon genes (STING)-activating nanoparticles can be employed as a tool for controlled immune activation
Authors: Dowaidar Moataz
Published: June 2021

Advances in materials and chemistry have helped stimulator of interferon genes (STING) agonists deliver nanomedicine, and drug delivery scientists have generated a spate of STING-activating nanocarriers capable of bypassing biological barriers for targeted innate and adaptive immune activation. Using STING-activating nanoparticles in antiviral vaccination has yielded several promising results in preclinical studies, and the strong antiviral humoral and cellular immunity elicited by these particulate adjuvants against HIV, influenza, and coronaviruses justifies the continued development of the platforms against the global infectious threat. STING-activating nanoparticles can be employed in virology and immunology research as a tool for controlled immune activation, as many processes underpinning STING-mediated immunological potency in viral infections are yet unclear. Because many of the nanoparticle platforms used to deliver STING agonists may also be utilized with various molecular adjuvants, these systems may be utilized to examine how diverse innate immune signals impact adaptive immunity production. Combinatorial nanoparticles mixing STING agonists with other molecular adjuvants may further increase antiviral protectivity by synergistically increasing immunological potential. Despite the promise of nanoparticulate vaccines, these synthetic nanoparticles are strikingly absent from COVID-19 vaccine research worldwide talks. Many elements, such as formulation safety, manufacturing scalability, storage, and deployment logistics, must be considered to achieve the enormous potential of the nanoparticulate STING agonists. Reduced synthetic methods and formulation lyophilization are important factors in platform designs to make antiviral vaccines accessible and affordable to poor nations. Nevertheless, the platform's great efficiency and wide use provide promise advances in both fundamental and translational research, opening the way to a deeper knowledge of viral containment and superior approaches.
Over-expression of La ribonucleoprotein domain family member 4B in human endometrial cancer.
Authors: Mamoor Shahan
Published: June 2021

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified La ribonucleoprotein domain family member 4B, encoded by LARP4B, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. LARP4B was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of LARP4B was correlated with recurrence-free survival in white patients with high mutational burden. LARP4B may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.
NATIONALISM EDUCATION (THEORY & APPLICATIONS) (PENDIDIKAN NASIONALISME (TEORI & APLIKASI))
Authors: Zahira Raisya Ghina , Pandin Moses Glorino Rumambo
Published: June 2021

The book entitled "Nationalism Education (Theory & Application)" was written by the author to straighten the meaning of nationalism in Islam. Today, nationalism has a lot of syiar and slogans that focus on three, namely freedom, nationality, and progress. This only eliminates the influence of Islam in the stage of life. This book is expected to help future generations know and follow the study results of the problem of nationalism itself. This book can read by various circles of society. However, the main thing is the millennial generation because it has contained teachings that can open the minds of the millennial generation to learn about nationalism not only by looking through its exterior window.
Gene modification research has potential, from diagnostic to therapeutic levels. The most promising metabolic pathways include the TGF-1 signaling system, inflammation and protein transport
Authors: Dowaidar Moataz
Published: June 2021

A human disease modifier gene is a gene that regulates another gene's function or effects. The presence of a modifier gene is not sufficient to cause a disease. Nonetheless, the presence of a modifier gene alters the disease's onset and severity. A genetic modifier can interact in several ways with another gene product. Changes in penetration and expressiveness, direct interaction with the target gene product, mechanistic contribution to the same biological process and/or functional compensation through other routes might all have effects. Despite long hypothesized genetic modifiers, their influence is yet unclear. Improved computational tools, international consortia with larger patient cohorts, improved laboratory precision procedures, and high-throughput technology have all helped find and verify genetic modifiers in recent years. As new possible genetic modifiers are found, common pathways can be established linking some modifying genes or neuromuscular diseases. The most promising metabolic pathways include the TGF-1 signaling system, inflammation, endoplasmic reticulum metabolism, axon formation, regeneration, extracellular matrix, RNA metabolism and protein transport. Perhaps in the future, we will conceive of neuromuscular diseases in terms of impaired molecular processes and the amount involving multiple metabolic pathways, rather than main genetic variations or medical nomenclature. Another fascinating feature of genetic modifiers in neuromuscular diseases is the involvement of genetic moderators in oligogenic inheritance. Preliminary research on animal models and people indicates that more rare, non-synonymous mutations in NMD-related genes might worsen muscle damage and lead to a more severe phenotype. Besides oligogenic inheritance, the "diagnostic gap"—individuals who remain unresolved after exome or genome sequencing—can be explained by the action of genetic modifiers. In the coming years, genetic modification research is expected to advance from diagnostic to therapeutic levels, and it would be extremely tempting from a therapeutic point of view to identify "protective" modifiers and comparable metabolic pathways for NMDs.
Sickle cell disease has emerged as a public health concern. Some drugs may conflict with curative therapies, yet they may be useful as a bridge to HSCT and gene therapy
Authors: Dowaidar Moataz
Published: June 2021

Sickle cell disease has resurfaced as a health-care priority in high-income nations and low-income countries (LMICs). Transplantation results with haploidentical haematopoietic stem cell transplantation (HSCT) are improving, increasing the likelihood of a curative treatment for the majority of patients. The indications for HSCT and for disease-modifying drugs, for example, must be determined. There are still a few things to think about, including biomarkers for systemic vasculopathy. Some medications may compete with curative treatments, but they might potentially be an important bridge treatment to HSCT. One of the most difficult hurdles yet ahead is reaching out to general practitioners and haematologists to bridge the awareness gap about curative alternatives such as matched sibling donor HSCT so that patients and their families may be identified early.
Medium, Small and Medium Enterprises and Digital Platforms
Authors: Thedy Christopher Carlos
Published: June 2021

Hasil dari survey terkait dengan bisnis tahun 2020-2021
Empowering the Creative Economy and UMKM in a Pandemic Period Through Digitalization
Authors: Halim Vincent Jonathan
Published: June 2021

memberdayakan kekreatifan oleh UMKM ditengah pandemi melalui digitalisasi
Hemophilia therapeutics
Authors: Dowaidar Moataz
Published: June 2021

Hemophilia is a genetic hemorrhagic condition marked by uncontrollable and persistent bleeding following surgery or trauma. Hemophilia A is the more common of the two, affecting 1:5000 newborn males in the population. Injecting factor replacement treatments are the most common therapy for hemophilia. The drugs that replaced the clotting factors VIII and IX were developed in the 1950s and 60s. They have been used to treat blood transfusions since the mid-1970s. The development of a humanized bispecific antibody (emicizumab; ACE910) that binds to FIX and FX and replicates the action of FVIII was a key breakthrough in hemophilia therapy. The cost of maintaining this antibody is high, and the feasibility of developing antibodies against the reactant has yet to be determined. Gene therapy is a promising alternative.
Book Review: “Buku Saku Millenial Mengawasi Pilkada 2020”
Authors: Madalena Suci
Published: June 2021

The Pocketbook of Millennials Supervising the 2020 Pilkada was written to provide knowledge and guidance to the millennial generation in implementing the 2020 elections. The importance of implementing the 2020 Pilkada, of course, cannot be separated from the Pilkada organizers themselves. Some of the reasons why the election is important, namely as a means of directly choosing candidates to lead in the future, being able to know the programs and vision and mission of prospective leaders during their future tenure, and the election results will determine the future of the region being led. As a millennial citizen aged 17 and has the right to vote, we must be an intelligent voter by paying attention to several things, such as ensuring that he has been registered in the DPT. Observing every vision and mission conveyed by each candidate, recognizing the background and curriculum vitae of the candidate, ensuring choice with the consideration which is good and faithful, chooses with the applicable election rules which can be considered "legally," Participates in overseeing the voting and counting and does not hesitate to report if suspicious things and are included in election violations.
Restoring the economy through digitalization
Authors: Azalia Vania
Published: June 2021

Restoring the economy through digitalization
SURAT 1 PETRUS DAN MISI: SEBUAH PERSPEKTIF
Authors: Simanjuntak Irfan Feriando
Published: June 2021

Artikel ini bertujuan untuk menunjukkan bahwa surat 1 Petrus adalah sebuah tulisan yang bermotif misi dan ditulis dengan kesadaran misi yang tinggi. Sekalipun surat ini tidak memuat dua kata paling signifikan yang berkaitan dengan misi, yakni ekklesia dan euangelizethai--yang menyebabkan banyak orang meng-klaim jika kitab ini tidak memiliki motif misi sama sekali, 1 Petrus merupakan gudang data tentang misi yang memberikan perspektif yang luas tentang misi. Dalam surat ini misi dikaitkan dengan identitas orang Kristen. Artinya menjadi Kristen berarti memanggul misi di pundaknya. Di samping itu misi juga dikaitkan dengan penderitaan, bukan dalam pengertian misi menghasilkan penderitaan melainkan melalui penderitaan misi tetap dapat dilakukan. Melalui surat ini juga dapat dilihat bahwa misi dapat dilakukan dengan cara, yaitu melalui pelayanan, perbuatan dan perkataan. Melalui penelitian yang intensif terhadap surat 1 Petrus, artikel ini akhirnya menyarankan sebuah redefinisi yang berkaitan dengan misi. Redefinisi tersebut diharapkan dapat meningkatkan kesadaran dan vitalitas orang Kristen dalam melaksanakan misi.
Book Review: All About National Insights in Context: Democracy, Citizenship, Social Integration (Serba-Serbi Wawasan Kebangsaan dalam Konteks: Demokrasi, Kewarganegaraan, hingga Integrasi Sosial)
Authors: 'Aisy Jihan Aqil Rihhadatul , Pandin Moses Glorino Rumambo
Published: June 2021

The science of citizenship is a crucial thing that must be present at every level of education, where the aim for citizens is to make them be able to think or to have a foundation of nationalism and patriotism that must be nurtured from an early age. It was written with the hope of strengthening the competence of students or the public in terms of knowledge and attitudes as a whole, where the process of achievement is through learning from several materials arranged in a continuous unit. The achievement of competence can be applied to the present and future life of the nation. This book provides useful information to increase national insight in the context of democracy, citizenship, and even social integration.This masterpiece provides an understanding of national insight or insight into the archipelago in the context of democracy, citizenship, to social integration. The insight of the archipelago is a teaching‘s belief about Indonesian people with the aim that there is no misleading or deviation in achieving and realizing national ideals and goals. Thus, the insight of the archipelago can become a vision foundation in carrying out national life in which basic things like this should be understood by the public (Indonesian people), especially students, as agents of change. The book certainly needs to be reviewed so that readers can find a brief synopsis of the book or a reviewer's assessment of this work which can be used as a consideration before reading it in its entirety. In a review, a reader can find out what urgency they have, so they are strongly advised to join in reading the book.
Gene-regulatory elements may change the amount, timing, or location of gene expression, cis-Regulation therapy platforms might become a gene therapy to treat many genetic diseases
Authors: Dowaidar Moataz
Published: June 2021

Changes in gene expression levels above or below a particular threshold may have a dramatic impact on phenotypes, leading to a wide spectrum of human illnesses. Gene-regulatory elements, also known as cis-regulatory elements (CREs), may change the amount, timing, or location (cell/tissue type) of gene expression, whereas mutations in a gene's coding sequence may result in lower or higher gene expression levels resulting in protein loss or gain. Loss-of-function mutations in both genes produce recessive human illness, while haploinsufficient mutations in 65 genes are also known to be deleterious due to function gain, according to the ClinVar1 and ClinGen3 databases. CREs are promoters living near to a gene's transcription start site and switching it on at predefined times, places, and levels. Other distal CREs, like enhancers and silencers, are temporal and tissue-specific control promoters. Enhancers activate promoters, commonly referred to as "promoters," whereas silencers turn them off. Insulators also restrict promiscuous interactions between enhancers and gene promoters. Systematic genomic approaches can help understand the cis-regulatory circuitry of gene expression by highly detecting and functionally defining these CREs. This includes the new use of CRISPR–CRISPR-associated protein 9 (CRISPR–Cas9) and other editing approaches to discover CREs. Cis-Regulation therapy (CRT) provides many promises to heal human ailments. CRT may be used to upregulate or downregulate disease-causing genes due to lower or higher levels of expression, and it may also be used to precisely adjust the expression of genes that assist in alleviating disease features. CRT may employ proteins that generate epigenetic modifications like methylation, histone modification, or gene expression regulation looping. Weighing CRT's advantages and downsides against alternative treatment methods is crucial. CRT platforms might become a practical technique to treat many genetic diseases that now lack treatment alternatives if academics, patient communities, clinicians, regulators and industry work together.
Precision medicine in refractory metastatic triple-negative breast cancer is enhanced by molecular subtyping and genomic profiling
Authors: P Rucha , S Vijay , P Rushabh
Published: June 2021

Triple-negative breast cancer (TNBC) is a very variable disease, and molecular subtyping may enable moreprecise diagnosis and treatment. Our earlier work categorized TNBCs into four subgroups, each with its ownset of potential treatment targets. To assess the effectiveness of these targets, we performed the study, a phaseIb/II subtyping-based and genomic biomarker-guided umbrella study. Patients with refractory metastaticTNBC were enrolled and assigned to one of seven arms: (A) pyrotinib plus capecitabine, (B) androgenreceptor inhibitor plus CDK4/6 inhibitor, (C) anti-PD-1 plus nab-paclitaxel, (D) PARP inhibitor plus nabpaclitaxel,(E) and (F) anti-VEGFR plus nab-paclitaxel, or (G The major outcome measure was the rate ofobjective response (ORR). We included 69 patients with resistant metastatic TNBC who had previouslyreceived a median of three lines of treatment (range, 1-8). Twenty-nine (29.0 percent, 95 percent confidenceinterval (CI): 18.7 percent -41.2 percent ) of the 69 intention-to-treat (ITT) patients obtained an objectiveresponse. Our findings indicated that immunotherapy (arm C) had the greatest ORR (52.6 percent, 95 percentconfidence interval [CI]: 28.9 percent -75.6 percent ) in the ITT group. Arm E had a good ORR (26.1 percent,95 percent CI: 10.2 percent -48.4 percent in the ITT group), but was associated with a higher prevalence ofsevere adverse events (grade 3). Somatic mutations in TOP2A and CD8 immunohistochemistry score may beable to predict immunotherapy response in patients with TNBC classified as immunomodulatory. Inconclusion, the phase Ib/II study demonstrated the therapeutic benefit of subtyping-based targeted therapy forrefractory metastatic TNBC.