bluuebunny/crossref_metadata_2025 huggingface dataset:
A Role for STOML3 in Olfactory Sensory Transduction
Authors: Agostinelli Emilio , Gonzalez-Velandia Kevin Y. , Hernandez-Clavijo Andres , Kumar Maurya Devendra , Xerxa Elena , Lewin Gary R. , Dibattista Michele , Menini Anna , Pifferi Simone
Published: February 2021

Stomatin-like protein-3 (STOML3) is an integral membrane protein expressed in the cilia of olfactory sensory neurons (OSNs), but its functional role in this cell type has never been addressed. STOML3 is also expressed in dorsal root ganglia neurons, where it has been shown to be required for normal touch sensation. Here, we extended previous results indicating that STOML3 is mainly expressed in the knob and proximal cilia of OSNs. We additionally showed that mice lacking STOML3 have a morphologically normal olfactory epithelium. Because of its presence in the cilia, together with known olfactory transduction components, we hypothesized that STOML3 could be involved in modulating odorant responses in OSNs. To investigate the functional role of STOML3, we performed loose patch recordings from wild-type (WT) andStoml3knock-out (KO) OSNs. We found that spontaneous mean firing activity was lower with additional shift in interspike intervals (ISIs) distributions inStoml3KOs compared with WT neurons. Moreover, the firing activity in response to stimuli was reduced both in spike number and duration in neurons lacking STOML3 compared with WT neurons. Control experiments suggested that the primary deficit in neurons lacking STOML3 was at the level of transduction and not at the level of action potential generation. We conclude that STOML3 has a physiological role in olfaction, being required for normal sensory encoding by OSNs.
A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear
Authors: Rajbhandari Abha K. , Octeau Christopher J. , Gonzalez Sarah , Pennington Zachary T. , Mohamed Farzanna , Trott Jeremy , Chavez Jasmine , Ngyuen Erin , Keces Natasha , Hong Weizhe Z. , Neve Rachael L. , Waschek James , Khakh Baljit S. , Fanselow Michael S.
Published: February 2021

Trauma can cause dysfunctional fear regulation leading some people to develop disorders, such as post-traumatic stress disorder (PTSD). The amygdala regulates fear, whereas PACAP (pituitary adenylate activating peptide) and PAC1 receptors are linked to PTSD symptom severity at genetic/epigenetic levels, with a strong link in females with PTSD. We discovered a PACAPergic projection from the basomedial amygdala (BMA) to the medial intercalated cells (mICCs) in adult mice.
In vivo
optogenetic stimulation of this pathway increased CFOS expression in mICCs, decreased fear recall, and increased fear extinction. Selective deletion of PAC1 receptors from the mICCs in females reduced fear acquisition, but enhanced fear generalization and reduced fear extinction in males. Optogenetic stimulation of the BMA-mICC PACAPergic pathway produced EPSCs in mICC neurons, which were enhanced by the PAC1 receptor antagonist, PACAP 6-38. Our findings show that mICCs modulate contextual fear in a dynamic and sex-dependent manner via a microcircuit containing the BMA and mICCs, and in a manner that was dependent on behavioral state.

SIGNIFICANCE STATEMENT
Traumatic stress can affect different aspects of fear behaviors, including fear learning, generalization of learned fear to novel contexts, how the fear of the original context is recalled, and how fear is reduced over time. While the amygdala has been studied for its role in regulation of different aspects of fear, the molecular circuitry of this structure is quite complex. In addition, aspects of fear can be modulated differently in males and females. Our findings show that a specific circuitry containing the neuropeptide PACAP and its receptor, PAC1, regulates various aspects of fear, including acquisition, generalization, recall, and extinction in a sexually dimorphic manner, characterizing a novel pathway that modulates traumatic fear.
The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim
Authors: Pearring Jillian N. , Martínez-Márquez Jorge , Willer Jason R. , Lieu Eric C. , Salinas Raquel Y. , Arshavsky Vadim Y.
Published: February 2021

Vision begins when light is captured by the outer segment organelle of photoreceptor cells in the retina. Outer segments are modified cilia filled with hundreds of flattened disk-shaped membranes. Disk membranes are separated from the surrounding plasma membrane, and each membrane type has unique protein components. The mechanisms underlying this protein sorting remain entirely unknown. In this study, we investigated the outer segment delivery of the rod cyclic nucleotide-gated (CNG) channel, which is located in the outer segment plasma membrane, where it mediates the electrical response to light. UsingXenopusand mouse models of both sexes, we now show that the targeted delivery of the CNG channel to the outer segment uses the conventional secretory pathway, including protein processing in both ER and Golgi, and requires preassembly of its constituent α1 and β1 subunits. We further demonstrate that the N-terminal glutamic acid-rich protein (GARP) domain of CNGβ1 contains two distinct functional regions. The glutamic acid-rich region encodes specific information targeting the channel to rod outer segments. The adjacent proline-enriched region connects the CNG channel to photoreceptor disk rims, likely through an interaction with peripherin-2. These data reveal fine functional specializations within the structural domains of the CNG channel and suggest that its sequestration to the outer segment plasma membrane requires an interaction with peripherin-2.

SIGNIFICANCE STATEMENTNeurons and other differentiated cells have a remarkable ability to deliver and organize signaling proteins at precise subcellular locations. We now report that the CNG channel, mediating the electrical response to light in rod photoreceptors, contains two specialized regions within the N terminus of its β-subunit: one responsible for delivery of this channel to the ciliary outer segment organelle and another for subsequent channel sequestration into the outer segment plasma membrane. These findings expand our understanding of the molecular specializations used by neurons to populate their critical functional compartments.
Consonance Preferences Within an Unconventional Tuning System
Authors: Friedman Ronald S. , Kowalewski Douglas A. , Vuvan Dominique T. , Neill W. Trammell
Published: February 2021

Recently, Bowling, Purves, and Gill (2018a), found that individuals perceive chords with spectra resembling a harmonic series as more consonant. This is consistent with their vocal similarity hypothesis (VSH), the notion that the experience of consonance is based on an evolved preference for sounds that resemble human vocalizations. To rule out confounding between harmonicity and familiarity, we extended Bowling et al.’s (2018a) procedure to chords from the unconventional Bohlen-Pierce chromatic just (BPCJ) scale. We also assessed whether the association between harmonicity and consonance was moderated by timbre by presenting chords generated from either piano or clarinet samples. Results failed to straightforwardly replicate this association; however, evidence of a positive correlation between harmonicity and consonance did emerge across timbres following post hoc exclusion of chords containing intervals that were particularly similar to conventional equal-tempered dyads. Supplementary regression analyses using a more comprehensive measure of harmonicity confirmed its positive association with consonance ratings of BPCJ chords, yet also showed that spectral interference independently contributed to these ratings. In sum, our results are consistent with the VSH; however, they also suggest that a composite model, incorporating both harmonicity as well as spectral interference as predictors, would best account for variance in consonance judgments.
Visualizing Debt and Credit in Hồ Chí Minh City
Authors: Lainez Nicolas
Published: February 2021

While conducting research on debt in the lives of sex workers in Hồ Chí Minh City, I stumbled upon an ad a moneylender had glued to a wall. It revealed that financialization was thriving in Vietnam, and more specifically that credit was rapidly expanding and colonizing the urban landscape. Photography became a tool to visually capture this radical financial transformation. This article argues that photography can be an effective inductive research method for moving from the particular to the general and seeing the big picture. I contend that looking at the world through the camera viewfinder with an open mind can help us to uncover hidden patterns and generate a rich and meaningful overall picture of a research problem. This process facilitates the formation of research perspectives and generalizations based on observations. I support this argument by describing the reflexive journey that drove me from photographing debt records in enclosed spaces to wandering in Hồ Chí Minh City’s streets to document a thriving credit boom. This journey radically transformed my research agenda on credit and debt.
Hybrid Electric Vehicles: A mini Overview
Authors: Muhammad Aisha , Haruna Ibrahim Shanono
Published: February 2021

The present greenhouse effect and its arrays of limitations on energy sources have made Hybrid Electric Vehicles (HEV’s) a current research focus due to its reduced amount of fuel usage.  The ability to simultaneously deliver power to the wheels from the mo-tor/engine made HEVs to have greater advantages (less fuel consumption and reduced internal combustion engine size without compromising the power output) over the tradi-tional vehicles. Despite its low patronage in markets, there is still hope that its popularity in the market will rise due to the superior qualities associated with it. This paper presented an brief review of Hybrid Electric Vehicles, by focusing on history, architecture and energy sources.
Role of AMPK in the protective effects exerted by triiodothyronine in ischemic-reperfused myocardium
Authors: Hermann Romina , Mestre Cordero Victoria Evangelina , Fernández Pazos María de las Mercedes , Córdoba Mailen Florencia , Reznik Federico Joaquín , Vélez Débora Elisabet , Fellet Andrea Lorena , Marina Prendes María Gabriela
Published: February 2021

Recent studies have provided evidence that triiodothyronine (T3) might play an effective role in the recovery of ischemic myocardium, through the preservation of mitochondrial function and the improvement of energy substrate metabolism. To this respect, it has been suggested that T3 could activate AMP-activated protein kinase (AMPK), the cellular ‘fuel-gauge’ enzyme, although its role has yet to be elucidated. The aim of the present study was to investigate the effects produced by acute treatment with T3 (60 nM) and the pharmacological inhibition of AMPK by compound C on isolated rat left atria subjected to 75 min simulated ischemia-75 min reperfusion. Results showed that T3 increased AMPK activation during simulated ischemia-reperfusion, while compound C prevented it. At the end of simulated reperfusion, acute T3 treatment increased contractile function recovery and cellular viability conservation. Mitochondrial ultrastructure was better preserved in the presence of T3 as well as mitochondrial ATP production rate and tissue ATP content. Calcium retention capacity, a parameter widely used as an indicator of the resistance of mitochondrial permeability transition pore (MPTP) to opening, and GSK-3β phosphorylation, a master switch enzyme that limits MPTP opening, were increased by T3 administration. All these beneficial effects exerted by T3 acute treatment were prevented when compound C was co-administrated. The present study provided original evidence that T3 enhances intrinsic activation of AMPK during myocardial ischemia-reperfusion, being this enzyme involved, at least in part, in the protective effects exerted by T3, contributing to mitochondrial structure and function preservation, post-ischemic contractile recovery and conservation of cellular viability.
First insights on seminal extracellular vesicles in chickens of contrasted fertility
Authors: Cordeiro Luiz , Lin Hsiu-Lien Herbie , Vitorino Carvalho Anaïs , Grasseau Isabelle , Uzbekov Rustem , Blesbois Elisabeth
Published: February 2021

Male subfertility causes are very varied and sometimes related to post-gonadic maturation disruption, involving seminal plasma constituents. Among them, extracellular vesicles are involved in key exchanges with sperm in mammals. However, in birds, the existence of seminal extracellular vesicles is still debated. The aim of the present work was first to clarify the putative presence of extracellular vesicles in the seminal plasma of chickens, secondly to characterize their size and protein markers in animals showing different fertility, and finally to make preliminary evaluations of their interactions with sperm. We successfully isolated extracellular vesicles from seminal plasma of males showing the highest differences in semen quality and fertility by using ultracentrifugation protocol (pool of 3 ejaculates/rooster, n =3/condition). Size characterization performed by electron microscopy revealed a high proportion of small extracellular vesicles (probably exosomes) in chicken seminal plasma. Smaller extracellular vesicles appeared more abundant in fertile than in subfertile roosters, with a mean diameter of 65.12 and 77.18 nm, respectively. Different protein markers of extracellular vesicles were found by western blotting (n = 6/condition). Among them, HSP90A was significantly more abundant in fertile than in subfertile males. In co-incubation experiments (n = 3/condition), extracellular vesicles enriched seminal fractions of fertile males showed a higher capacity to be incorporated into fertile than into subfertile sperm. Sperm viability and motility were impacted by the presence of extracellular vesicles from fertile males. In conclusion, we successfully demonstrated the presence of extracellular vesicles in chicken seminal plasma, with differential size, protein markers and putative incorporation capacity according to male fertility status.
A French corpus annotated for multiword expressions and named entities
Authors: Candito Marie , Constant Mathieu , Ramisch Carlos , Savary Agata , Guillaume Bruno , Parmentier Yannick , Cordeiro Silvio
Published: February 2021

We present the enrichment of a French treebank of various genres with a new annotation layer for multiword expressions (MWEs) and named entities (NEs).1 Our contribution with respect to previous work on NE and MWE annotation is the particular care taken to use formal criteria, organized into decision flowcharts, shedding some light on the interactions between NEs and MWEs. Moreover, in order to cope with the well-known difficulty to draw a clear-cut frontier between compositional expressions and MWEs, we chose to use sufficient criteria only. As a result, annotated MWEs satisfy a varying number of sufficient criteria, accounting for the scalar nature of the MWE status. In addition to the span of the elements, annotation includes the subcategory of NEs (e.g., person, location) and one matching sufficient criterion for non-verbal MWEs (e.g., lexical substitution). The 3,099 sentences of the treebank were double-annotated and adjudicated, and we paid attention to cross-type consistency and compatibility with thesyntactic layer. Overall inter-annotator agreement on non-verbal MWEs and NEs reached 71.1%. The released corpus contains 3,112 annotated NEs and 3,440 MWEs, and is distributed under an open license.
Ukrainian language as a factor of state formation: scientific principles and models of implementation (transcript of scientific report at the meeting of the Presidium of NAS of Ukraine, January 20, 2021)
Authors:   Institute of Ukrainian Language of the National Academy of Sciences of Ukraine , Kyiv, Ukraine, Hrytsenko Pavlo Yu.
Published: February 2021

The report emphasizes that the language development of the state remains a priority for the legislative and executive power, academics and the public. In recent years, the volume and complexity of the study of the Ukrainian language has increased, including substantiation of ways and forms of nationalization of the Ukrainian language, achieving conflict-free linguistic existence of society, which requires further development and deepening of academic research, expansion of issues aimed at meeting the practical needs of state building, improving the structure and expanding staffing and logistics of the basic institution in linguo-ukrainistic studies: the Institute of the Ukrainian Language of the NAS of Ukraine.
Model Satisfaction Users Measurement of Academic Information System Using End-User Computing Satisfaction (EUCS) Method
Authors: Hidayah Nur Aeni , Fetrina Elvi , Taufan Alvali Zaqi
Published: February 2021

As concrete steps in order to realize the vision and mission of an organization or educational institution is to implement the system of academic information. The one factor that influences the success of the academic information system is the satisfaction of users.  The problems in the user satisfaction are also issues that cannot be denied and continue to be studied. In consequently, having measurements related to user satisfaction is required. This research is done to see how the user satisfaction of the existing system has been implemented and to know what factorshas influenced the system. The method used in this study is a quantitative method using the End User Computing Satisfaction (EUCS) model whereas 255 respondents are chosen as the sample for the study. The purposive sampling technique is usedand the PLS-SEM approach with tools Smart PLS 3.0 is used for analyzing the data.  This research consists of 7 hypotheses and 8 variables, namely Content, Accuracy, Format, Timeliness, Ease of Use, System Reliability, System Speed and End-User Satisfaction. The research finds out that the current level of end-user satisfaction is in satisfied level. Inferentially, of the 7 hypotheses tested, 2 of them were rejected and the other 5; Accuracy, System Reliability, Timeliness, Content and System Spee;are accepted.Through this research, it is hoped that later it could be used as a practical consideration and theoretical study in thefuture.
IMPLEMENTASI METODE WATERFALL PADA PERANCANGAN SISTEM INFORMASI KOPERASI SIMPAN PINJAM BERBASIS WEB DAN ANDROID (STUDI KASUS PT. PEB)
Authors: Saputri Galuh , Eriana Emi Sita
Published: February 2021

PEB Cooperative is a savings and loan cooperative which is intended for employees of PT. PEB, is engaged in the garment industry. Established since 15 years with the number of cooperative members who are permanent employees of the company. This cooperative becomes an economical shelter to meet the needs of its employees. Technology in admin data processing is still simple using Microsoft Excel tools, in applications that connect members with admins on this system have not been designed, so from the background of this research will design a web-based and android-based savings and loan cooperative information system This design uses the waterfall model which will take a sequential design making it easier for developers and users. The hope is that this design will help make transactions for savings, loans, deposits, data collection, and reports to members, admins and leaders. The results obtained from the questionnaire with the System Usability Scale method in this savings and loan cooperative application are easy to use, faster, and practical, stated by the cooperative members by 84% and cooperative managers by 80%. It can be concluded that this application that has been designed can make it easier to carry out savings and loan transactions quickly and practically.
Reconsidering Humanist Chaplaincy for a Plural Society
Authors: Jacobs Gaby , Damen Annelieke , Suransky Caroline , Kate Laurens ten
Published: February 2021

Recent developments in Dutch society and its healthcare system pose new challenges to humanist chaplaincy. Thus far, chaplaincy has been predominantly rooted in institutionalized religion, but it now has to serve a diversity of people who are increasingly secularized with personal ways of worldviewing. Moreover, chaplaincy is increasingly becoming a profession like many others, reducing the focus on its worldviewing competencies. The main question this article addresses is what this implies for the education of chaplains, more specifically for humanist chaplains who are educated on a Master’s level course at the University of Humanistic Studies. Using the concepts of interprofessional learning communities (Stoll & Seashore Louis, 2007) and dialogical professionalism (Jacobs, 2010), two visions are put forward for developing the education of humanist chaplains that might also be relevant for other chaplaincy educational programs.
Olsen, C. (2017). Loneliness: Caring for yourself and others.
Authors: Mercer Tim
Published: February 2021

Olsen, C. (2017). Loneliness: Caring for yourself and others. Chawton: Redemptorist Publications. 62 pp. (Pbk). ISBN: 978-0852315057.
Realistic simulation is associated with healthcare professionals’ increased self-perception of confidence in providing acute stroke care: a before-after controlled study
Authors: FARIAS DA GUARDA Suzete Nascimento , SANTOS João Pedro Souza , REIS Mariana Sampaio Motta , PASSOS Rogério da Hora , CORREIA Luis Claúdio , CALDAS Juliana Ribeiro , GOBATTO André Luiz Nunes , TEIXEIRA Maurício , OLIVEIRA Adelmo , RIBEIRO Michel Pordeus , BATISTA Paulo Benigno Pena , CALDERARO Marcelo , PASCHOAL JUNIOR Fernando , PONTES-NETO Octávio Marques , RAMOS João Gabriel Rosa
Published: February 2021

ABSTRACT Background: Simulations are becoming widely used in medical education, but there is little evidence of their effectiveness on neurocritical care. Because acute stroke is a neurological emergency demanding prompt attention, it is a promising candidate for simulation training. Objective: To assess the impact of a stroke realistic simulation course on clinicians’ self-perception of confidence in the management of acute stroke. Methods: We conducted a controlled, before-after study. For our intervention, 17 healthcare professionals participated in a stroke realistic simulation course. As controls, participants were chosen from a convenience sample of attendees to the courses Emergency Neurologic Life Support (ENLS) (18 participants) and Neurosonology (20 participants). All participants responded pre- and post-test questionnaires evaluating their self-perception of confidence in acute stroke care, ranging from 10 to 50 points. We evaluated the variation between pre- and post-test results to assess the change on trainees’ self-perception of confidence in the management of acute stroke. Multivariate analysis was performed to control for potential confounders. Results: Forty-six (83.63%) subjects completed both questionnaires. The post-test scores were higher than those from the pretests in the stroke realistic simulation course group [pretest median (interquartile range - IQR): 41.5 (36.7-46.5) and post-test median (IQR): 47 (44.7-48); p=0.033], but not in the neurosonology [pretest median (IQR): 46 (44-47) and post-test median (IQR): 46 (44-47); p=0.739] or the ENLS [pretest median (IQR): 46.5 (39-48.2), post-test median (IQR): 47 (40.2-49); p=0.317] groups. Results were maintained after adjustment for covariates. Conclusions: This stroke realistic simulation course was associated with an improvement on trainees’ self-perception of confidence in providing acute stroke care.
Blood-cerebrospinal fluid (CSF) barrier dysfunction means reduced CSF flow not barrier leakage - conclusions from CSF protein data
Authors: REIBER Hansotto
Published: February 2021

ABSTRACT Background: Increased concentrations of serum proteins in cerebrospinal fluid (CSF) are interpreted as blood-CSF barrier dysfunction. Frequently used interpretations such as barrier leakage, disruption or breakdown contradict CSF protein data, which suggest a reduced CSF flow rate as the cause. Results: Even the severest barrier dysfunctions do not change the molecular size-dependent selectivity or the interindividual variation of the protein transfer across barriers. Serum protein concentrations in lumbar CSF increase with hyperbolic functions, but the levels of proteins that do not pass the barrier remain constant (brain proteins) or increase linearly (leptomeningal proteins). All CSF protein dynamics above and below a lumbar blockade can also be explained, independent of their barrier passage, by a reduced caudally directed flow. Local accumulation of gadolinium in multiple sclerosis (MS) is now understood as due to reduced bulk flow elimination by interstitial fluid (ISF). Nonlinear change of the steady state in barrier dysfunction and along normal rostro-caudal gradients supports the diffusion/flow model and contradicts obstructions of diffusion pathways. Regardless of the cause of the disease, pathophysiological flow blockages are found in bacterial meningitis, leukemia, meningeal carcinomatosis, Guillain-Barré syndrome, MS and experimental allergic encephalomyelitis. In humans, the fortyfold higher albumin concentrations in early fetal development decrease later with maturation of the arachnoid villi, i.e., with beginning CSF outflow, which contradicts a relevant outflow to the lymphatic system. Respiration- and heartbeat-dependent oscillations do not disturb net direction of CSF flow. Conclusion: Blood-CSF and blood-brain barrier dysfunctions are an expression of reduced CSF or ISF flow rate.
The controversial Third Reich history of Hans Creutzfeldt: was he a supporter or just another adept of the “hand washing policy”?
Authors: CARRILHO Paulo Eduardo Mestrinelli , NITRINI Ricardo
Published: February 2021

ABSTRACT Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy whose initial description is associated with two German authors, Alfons Maria Jakob and Hans Gerhard Creutzfeldt. As polemic as the issue about the Creutzfeldt’s merit in the first description of the disease, is his history during the Third Reich. Some evidence pointed to the idea that he was essentially against the Nazi ideology, though some did not. He was an official member of the SS, but his own wife was convicted by a Nazi court. Some authors have argued that Creutzfeldt helped save many patients during Aktion T4 operation, but, in fact, he could have done more. Even during the post-war period, he sent a letter to authorities reporting the name of a Nazi physician who worked as a medical reviewer at the euthanasia court, but he did not proceed any further when his letter initially failed to start an investigation.
The impact of physical functions on depressive symptoms in people with multiple sclerosis
Authors: TAUIL Carlos Bernardo , RAMARI Cintia , DA SILVA Flávia Martins , BRASIL Erica , DAVID Ana de , GOMES Jaqueline Ramos Andrade , SILVA Felipe von Glehn , BRANDÃO Carlos Otávio , DOS SANTOS Leonilda Maria Barbosa , SANTOS-NETO Leopoldo dos
Published: February 2021

ABSTRACT Background: Multiple sclerosis (MS) is an immune-mediated disease that affects the central nervous system. The impact of MS transcends physical functions and extends to psychological impairment. Approximately 50% of people with MS develop depressive symptoms during their lifetime and depressive symptoms may predict impairment of physical functions. However, prediction of depressive symptoms based on objective measures of physical functions is still necessary. Objective: To compare physical functions between people with MS presenting depressive symptoms or not and to identify predictors of depressive symptoms using objective measures of physical functions. Methods: Cross-sectional study including 26 people with MS. Anxiety and/or depressive symptoms were assessed by the Beck Depression Inventory-II (BDI-II) and by the Hospital Anxiety and Depression Scale (HADS). Outcomes of physical functions included: the Nnnine-hole Ppeg Ttest (NHPT), knee muscle strength, balance control, the Timed Up and Go Test (TUG), and the 6-minute walk test (6MWT). Perceived exertion was measured using the Borg scale. Results: The frequency of depressive symptoms was 42% in people with MS. Balance control during a more challenging task was impaired in people with MS who presented depressive symptoms. Balance could explain 21-24% of the variance in depressive symptoms. 6MWT and TUG presented a trend of significance explaining 16% of the variance in the BDI-II score. Conclusions: Impairment in physical functions consists in a potential predictor of depressive symptoms in people with MS. Exercise interventions aiming at the improvement of physical functions, together with the treatment of depressive symptoms and conventional medical treatment, are suggested.
Reformadores da escravidão Brasil e Cuba c. 1790 e 1840
Authors: RAMINELLI Ronald
Published: February 2021

Resumo O artigo analisa debates sobre a escravidão em Cuba e Brasil, entre as décadas de 1790 e 1840. Em conjunturas distintas, os reformadores se dividiam entre escravistas e abolicionistas e discutiam a inserção de afrodescendentes nas mencionadas sociedades. Os primeiros defendiam não somente a escravidão, mas a inserção dos escravos, negros e mulatos livres como parte da heterogênea população brasileira e cubana. No entanto, os abolicionistas consideravam a mistura de raças como entrave à formação da nação ou origem de possíveis dificuldades de integração social. Diferentemente dos escravistas, eles defendiam a homogeneidade da população, repudiavam o aumento desproporcional de "inimigos internos" e incentivavam a imigração europeia. A "racialização" do projeto de nação era uma tendência mais evidente nos escritos portugueses e brasileiros antes da década de 1830. Em Cuba, o esse debate se tornou mais intenso com a percepção do aumento da população negra e de mulatos a partir da década de 1830.
Aquatic larval of the genus Arrenurus (Trombidiformes: Parasitengonina: Arrenuridae) associated with Odonata species from Pampa Biome, Brazil
Authors: Bizarro Gabriel Lima , Périco Eduardo , Dalzochio Marina , Silva Guilherme Liberato da , Ferla Noeli Juarez , Johann Liana
Published: February 2021

Abstract: Many studies have reported that the interaction between water mite larvae and their Odonata hosts affects mating success, flight, and longevity. Males and females of Odonata species collected in the steppes and coastal plains (Pampa Biome) of Rio Grande do Sul were analyzed. Mites were removed when present and the prevalence and intensity of parasites was calculated. The aim of this study was to search and report new Odonata hosts species that are parasitized by water mite larvae and also to evaluate the prevalence and intensity rates; the differences in mite occurrence and frequency between males and females, and between thorax and abdomen of the dragonflies and damselflies in the southern Pampa biome located in Rio Grande do Sul. A total of 162 larval mites were found associated to two Odonata families: Coenagrionidae (Acanthagrion lancea Selys, 1876, Ischnura capreolus Hagen, 1861 and Ischnura fluviatilis Selys, 1876) and Libelullidae (Micrathyria ocellata Martin, 1897 and Perithemis mooma Kirby, 1889). All mites were identified as Arrenurus (Arrenurus) sp. (Arrenuridae) and showed high numbers when attached to I. capreolus (55.5%), I. fluviatilis (33.3%), followed by low numbers on M. ocellata (6.1%), A. lancea (3.7%), and P. mooma (1.2%). Mites were found on males and females of I. capreolus and I. fluviatilis, females of A. lancea and P. mooma and in M. ocellata only in males. As the parasitized Odonata species are generalist and abundant in all water body types, traits associated with mating and oviposition or larval behavior are believed to explain the frequency of parasitism in these species.
Construção de um luxímetro digital utilizando plataforma Arduino para uso em laboratórios didáticos
Authors: Pereira C. B. , Berleze S. L. M. , Soares W. A. , Serbena J. P. M.
Published: February 2021

Este trabalho teve como finalidade a construção de um luxímetro utilizando um fotodetector/conversor luz em frequência (LTF, do inglês “light to frequency”) e plataforma Arduino. As etapas de execução consistiram no desenvolvimento do código de programação da comunicação e controle entre fotodetector e Arduino, na confecção de uma placa de circuito impresso caseira e no acabamento do luxímetro com a inserção de botões, display e demais componentes eletrônicos numa caixa Patola®. O luxímetro construído foi utilizado em três experimentos didáticos realizados na disciplina de laboratório dos cursos de graduação em Física e Engenharias cujo tema estudado é a Óptica. As medidas realizadas demonstraram que o luxímetro atende à necessidade do laboratório ao substituir equipamentos comerciais atualmente utilizados.
Social representations of comfort for patients’ family members in palliative care in intensive care
Authors: Perão Odisséia Fátima , Nascimento Eliane Regina Pereira do , Padilha Maria Itayra Coelho de Souza , Lazzari Daniele Delacanal , Hermida Patrícia Madalena Vieira , Kersten Mayara Ana da Cunha
Published: February 2021

ABSTRACT Objective: To know the social representations of comfort for patients’ family members in palliative care in intensive care. Method: Descriptive, qualitative study, theoretical framework adopted was Social Representations. 30 family members of patients admitted to an intensive care unit in palliative care participated. Data were collected through semi-structured individual interviews, organized and analyzed using the Collective Subject Discourse technique. Results: Pointed out as central ideas, positive and negative feelings of family members, communication and interaction with the team, ICU as excellence and palliative care as a measure of comfort for the patient and the family. Conclusion: The social representations about the comfort of family members of hospitalized patients in an intensive care unit in palliative care are identified by the family members’ feelings during the visit, communication, and the humanized care applied by nursing professionals in the patients in palliative care.
Informational support for families of children with autism spectrum disorder
Authors: Weissheimer Gisele , Mazza Verônica de Azevedo , Freitas Cibelly Aliny Siqueira Lima , Silva Silvana Rodrigues da
Published: February 2021

ABSTRACT Objective: To identify the sources of informational support used by families of children with Autism Spectrum Disorder. Method: Qualitative and descriptive research carried out in three health institutions and three teaching institutions in Paraná, Ceará and Amapá. 55 family members participated who responded to semi-structured interviews, between September 2018 and 2019. Thematic categorical analysis and the resources of Qualitative Data Analysis Software were used. Results: Families find informational support from several sources, both formal and informal, such as the internet and other sources (books, Workshops, courses, television). Conclusion: Families use different sources of information, however, often incomplete and contradictory, which can generate a new demand on health professionals, in order to integrate access to information in the health care process, since they must be considering benefits and weaknesses that this represents for society.
A linguagem tabu em contexto: um estudo exploratório da linguagem tabu do ponto de vista das variáveis do registro
Authors: Xavier Catarina
Published: February 2021

RESUMO Os falantes interagem através dos recursos linguísticos ao seu dispor para produzir significados ao nível da compreensão do mundo que os rodeia e dos restantes falantes (EGGINS, [1994] 2004, p. 11). O falante conhece, então, um código para cada situação comunicativa e adequa as suas seleções estilísticas ao contexto em que as produz. Neste enquadramento, este artigo exploratório investiga a linguagem tabu do ponto de vista das variáveis do contexto situacional, como propostas por Halliday (1978, [1985] 2014). Segue, por um lado, uma abordagem teórica onde propõe o cruzamento das variáveis do registro com os conceitos de uso marcado e não marcado (HYMES, 1974); e, por outro, aplica esta proposta num corpus escolhido para o efeito. Os resultados, de ordem quantitativa, demonstram o predomínio do uso não marcado da linguagem tabu no corpus.
A escrita de resumos no quadro dos letramentos acadêmicos de estudantes de graduação
Authors: Melo Bárbara Olímpia Ramos de , Bezerra Benedito Gomes
Published: February 2021

RESUMO A produção escrita de resumos de trabalhos científicos integra práticas de letramento complexas e diversificadas, das quais os estudantes são chamados a participar desde a graduação universitária. Neste estudo, sob a perspectiva dos estudos de letramento e de teorias de gênero aplicadas à escrita acadêmica, analisamos 32 exemplares de resumos, observando sua configuração retórica como um dos elementos indicadores dos letramentos acadêmicos de estudantes de graduação. Observações adicionais sobre os letramentos acadêmicos dos autores foram construídas a partir da aplicação de um questionário enviado por e-mail. Os resultados sugerem certa flexibilidade tanto da parte dos alunos como dos participantes experimentados da comunidade discursiva em lidar com as convenções que regem a construção do resumo acadêmico.
Dialysis-related thrombocytopenia: a case report
Authors: Duayer Irene Faria , Araújo Maria Júlia Correia Lima Nepomuceno , Nihei Camila Hitomi , Barcelos Maria Alice Fernandes , Braga Osni , Britto Zita Maria Leme , Elias Rosilene Mota
Published: February 2021

Abstract Thrombocytopenia is frequently observed in hemodialysis patients, and its correct investigation and control remain a challenge. It is estimated that during the hemodialysis session there is a drop of up to 15% in the platelet count, with recovery after the end of treatment. This reduction in platelets is due to platelet adhesion and complement activation, regardless of the membrane material. Several studies with platelet surface markers demonstrate increased platelet activation and aggregation secondary to exposure to cardiopulmonary bypass. This case report describes a patient on hemodialysis who developed severe thrombocytopenia during hospitalization. Investigation and exclusion of the most common causes were carried out: heparin-related thrombocytopenia, adverse drug reaction, hypersplenism, and hematological diseases. Afterwards, the possibility of hemodialysis-related thrombocytopenia was raised, since the fall was accentuated during the sessions with partial recovery after the dialyzer change. Attention to the sterilization method and dialyzer reuse must be considered for correction. In the current case, reusing the dialyzer minimized the drop in platelet counts associated with hemodialysis.
AGEs accumulation is related to muscle degeneration and vascular calcification in peritoneal dialysis patients
Authors: Fonseca Laís de Faria , Araújo Anna Beatriz , Quadros Kélcia Rosana da Silva , Carbonara Cinthia Esbrile Moraes , Dertkigil Sérgio San Juan , Sposito Andrei Carvalho , Oliveira Rodrigo Bueno de
Published: February 2021

Abstract Background: Patients with chronic kidney disease (CKD) are affected by dynapenia, sarcopenia, and vascular calcification. Advanced glycation end products (AGEs) may accumulate in peritoneal dialysis (PD) patients and favor sarcopenia via changes in collagen cross-linking, muscle protein breakdown, and the calcification of arterial smooth muscle cells via p38-MAPK activation. The aim of this study is to explore the relationships between AGEs, muscle degeneration, and coronary artery calcification. Methods: This was a clinical observational study in patients with CKD undergoing PD, in which serum and skin AGEs (AGEs-sAF), cumulative glucose load, muscle strength and functional tests, muscle ultrasounds with elastography, coronary artery calcium (CAC) quantification, and muscle density by multislice computed tomography were measured. Results: 27 patients aged 48±16 years, dialysis vintage of 27±17 months, had AGEs-sAF levels of 3.09±0.65 AU (elevated in 13 [87%] patients), grip strength levels of 26.2±9.2 kg (11 [42%] patients with dynapenia), gait speed of 1.04±0.3 m/s (abnormal in 14 [58%] patients) and "timed-up-and-go test" (TUG) of 10.5±2.2s (abnormal in 7 [26%] patients). Correlations between AGEs-sAF levels and femoral rectus elastography (R=-0.74; p=0.02), anterior-tibialis elastography (R= -0.68; p=0.04) and CAC (R=0.64; p=0.04) were detected. Cumulative glucose load correlated with femoral rectal elastography (R=-0.6; p=0.02), and serum glycated hemoglobin concentrations correlated with psoas muscle density (R= -0.58; p=0.04) and CAC correlated with psoas muscle density (R=0.57; p=0.01) and lumbar square muscle density (R=-0.63; p=0.005). Conclusions: The study revealed associations between AGEs accumulation and lower muscle stiffness/density. Associations that linked muscle degeneration parameters with vascular calcification were observed.
Well-being and disease severity of multiple sclerosis patients following a physical activity program
Authors: Pedro Luísa , Pais-Ribeiro José , Pinheiro João Páscoa
Published: February 2021

Abstract Introduction: Multiple sclerosis (MS) is a chronic disease of the central nervous system that mainly affects young adults, promoting a great impact on functionality. Fatigue is a very common symptom, associated with multiple impairments in sensitivity, muscle activity, neuromotor control, balance, cognition and problem-solving ability. MS leads to strong functional restrictions, particularly in the context of daily living activities, as well as in patient participation. Objective: To understand the implications of a self-regulation program in the perception of well-being and mental health in MS patients. Methods: A set of exercises was implemented for use in daily activities, supported by different studies with MS patients. Patients were asked to classify the severity of their disease and to use the Mental Health Inventory (MHI-38), at the beginning (time A) and at the end (time B) of the self-regulation program. We used the Statistical Package for the Social Sciences (SPSS) version 25. A non-parametric statistical hypothesis test (Wilcoxon test) was used to analyze the variables. Results: The mean age was 44 years old, with patients between the ages of 20 and 58. 58.3% were women, 37.5% were currently married, 67% were retired and the mean level of education was 12.5 years. The correlation between the perception of disease severity and psychological well-being before the self-regulation program (r = 0.26, p < 0.05) and after the intervention (r = 0.37, p < 0.01) suggests a low to moderate correlation. Conclusion: The implementation of the self-regulatory model, through the promotion of physical activity in patients with MS, had a positive impact of clinical rehabilitation, well-being, and perception of disease severity of these people.
BRAZILIAN IBD STUDY GROUP POSITION STATEMENT ON SARS-COV2 VACCINATION
Authors: QUEIROZ Natália Sousa Freitas , TEIXEIRA Fábio Vieira , FREIRE Caio Cesar Furtado , MOTTA Marina Pamponet , VASCONCELLOS Marcela Almeida Menezes de , CHEBLI Liliana Andrade , SAAD-HOSSNE Rogerio
Published: February 2021

ABSTRACT Mass vaccination offers the best strategy to fight against COVID-19 pandemic, and SARS-CoV2 vaccines are being approved in several countries for emergency use. In Brazil, vaccine approval is expected in the next few days, however potential concerns exist regarding vaccine recommendations for specific populations, such as patients with inflammatory bowel disease (IBD). To address these questions, the Brazilian IBD Study Group (GEDIIB) provides this practical advice with key recommendations about the COVID-19 vaccines in IBD population.
Estrutura e processo de trabalho para as ações de alimentação e nutrição na Atenção Primária à Saúde no Brasil, 2014
Authors: Machado Patrícia Maria de Oliveira , Lacerda Josimari Telino de , Colussi Claudia Flemming , Calvo Maria Cristina Marino
Published: February 2021

Resumo Objetivo: Avaliar as condições de estrutura e de processo de trabalho para as ações de alimentação e nutrição na Atenção Primária à Saúde, no Brasil. Métodos: Estudo transversal, sobre dados secundários do Programa de Melhoria do Acesso e da Qualidade da Atenção Básica. Foram descritas as proporções de adequação das unidades básicas de saúde (UBS) e equipes de saúde segundo variáveis organizacionais, pela razão da prevalência e regressão de Poisson. Resultados: Foram analisadas 19.793 UBS e 24.549 equipes; 35,0% (n=6.928) das UBS mostraram-se adequadas na estrutura e 7,9% (n=1.934) das equipes adequadas ao processo de trabalho. Nas análises de associação, destacaram-se as UBS da região Sul (44,7%) e as equipes da região Sudeste (10,9%), além de municípios com mais de 300 mil habitantes. Conclusão: As UBS e equipes analisadas apresentaram baixas proporções de adequação de estrutura e de processo de trabalho para as ações de alimentação e nutrição.
População com risco cardiovascular elevado em uso de medicamento e aconselhamento: a situação do Brasil em relação à meta mundial, 2014-2015
Authors: Malta Deborah Carvalho , Pinheiro Pedro Cisalpino , Andrade Fabiana Martins Dias de , Sardinha Luciana Monteiro Vasconcelos , Matoso Leonardo Ferreira , Caixeta Roberta de Betânia , Ondarsuhu Dolores
Published: February 2021

Resumo Objetivo: Estimar a prevalência de risco cardiovascular (RCV) elevado, a proporção de pessoas com RCV elevado que recebem tratamento e aconselhamento, e investigar os fatores sociodemográficos associados ao desfecho, no Brasil. Métodos: Estudo transversal, com dados de subamostra da Pesquisa Nacional de Saúde, coletados por exames bioquímicos, em 2014-2015. Empregou-se regressão de Poisson. Resultados: A proporção de RCV elevado em homens foi de 11,2% (IC95% 9,6;12,9), e em mulheres, de 10,4% (IC95% 9,2;11,8%). No grupo com RCV elevado, 68,8% (IC95% 63,7;73,4%) receberam aconselhamento; 59,3% (IC95% 54,2;64,3%), medicamento; e 55,6% (IC95% 50,4;60,7%), ambos. Na análise multivariável, receber tratamento e aconselhamento mostrou associação com a idade de 50 anos e mais, e com autoavaliação de saúde ruim/muito ruim (RP=1,26 - IC95% 1,06;1,51). Conclusão: A proporção de pessoas com RCV elevado que receberam tratamento e aconselhamento foi superior a 50%.
Gastos com internações psiquiátricas no estado de São Paulo: estudo ecológico descritivo, 2014 e 2019
Authors: Dias Bruna Moreno , Badagnan Heloisa França , Marchetti Silvana Proença , Zanetti Ariane Cristina Barboza
Published: February 2021

Resumo Objetivo: Analisar os gastos com internações psiquiátricas no estado de São Paulo, Brasil, nos anos de 2014 e 2019. Métodos: Estudo ecológico descritivo, com análise de dados das internações hospitalares psiquiátricas no estado, obtidos do Sistema de Informações Hospitalares do Sistema Único de Saúde. Resultados: Foram analisadas 115.652 internações ocorridas em 2014, e 79.355 em 2019 (redução de 31,38%). Observaram-se reduções nos valores gastos com internações psiquiátricas (-42,94%), destacando-se as internações de caráter de urgência, de pessoas do sexo feminino (-46,46%), nas idades de 15 a 49 (-36,85%) e mais de 50 anos (-51,54%). Conclusão: As reduções de frequência e de valores gastos com internações psiquiátricas fornecem elementos para a avaliação e alocação de recursos destinados à atenção da saúde mental, no âmbito das internações hospitalares e da utilização de serviços de base comunitária.