bluuebunny/crossref_metadata_2025 huggingface dataset:
Sounds with high-frequency components above the human audible range improve glucose tolerance: A quasi-experimental crossover study
Authors: Kawai Norie , Honda Manabu , Nishina Emi , Ueno Osamu , Fukushima Ariko , Ohmura Rikka , Fujita Nahiko , Oohashi Tsutomu
Published: July 2022

Although stress has a significant impact on various metabolic syndrome, including diabetes mellitus, most stress management techniques are psychological and subjective approaches. We previously reported that sounds rich in inaudible high-frequency component (HFC) activate deep-brain structures such as midbrain, thalamus and hypothalamus, which are closely related to stress reactions. The present study examined how the presence or absence of the inaudible HFC of sounds affects glucose tolerance in healthy subjects using oral glucose tolerance test (OGTT). Sounds containing HFC suppressed the increase in blood glucose levels in the OGTT compared with the otherwise same sounds without HFC. The suppression effect of HFC was more prominent in the older age group and the group with high HbA1c. This suggests that sounds with HFC are more effective in improving glucose tolerance in individuals who have potentially impaired glucose tolerance. This study provides a proof of concept for future investigation that sounds rich in HFC may be an effective nonpharmacological alternative for people with abnormal glucose tolerance function.
Whole genome sequence of mulberry crinivirus (MuCV), an uncommon crinivirus containing a tRNA-like structure at the 5'- and 3'-ends of RNA1
Authors: Lu Quan-You , Zhang Peng , Han Tao-Tao , Tang Jia-Xuan , Zhong Kui , Ma Yu , Smith William-Kojo , Zhao Wei-Guo
Published: July 2022

The whole genome sequence of mulberry crinivirus (MuCV), a novel member of the genus Crinivirus (family Closteroviridae) identified from mulberry (Morus alba L), was determined. The bipartite genome of MuCV consists of RNA1, which contains 8571 nucleotides (nt) with four putative open reading frames (ORFs), and RNA2, which contains 8082 nt with eight putative ORFs. The most striking features exhibited by MuCV are tRNA-like structures at the 5'- and 3' -ends of RNA1, which have not been reported for all known members of the family Closteroviridae. Phylogenetic analysis based on RdRp amino acid sequences of criniviruses placed MuCV in “Group 1”.
The Improved X-ray Detector (iXRD) on Sharjah-Sat-1, design principles, tests and ground calibration
Authors: Kalemci Emrah , Altingun Ali M. , Bozkurt Ayhan , Aslan Alim Rustem , Yalcin Refik , Gokalp Kaya , Veziroglu Kaan , Fernini Ilias , Manousakis Antonios , Yasar Ali , Diba Milad , Karabulut Bogac , Catal Egemen , Oztekin Onur
Published: July 2022

The ixRD is the primary science payload on Sharjah-Sat-1, a 3U CubeSat expected to be launched in Q4, 2022. Its main scientific goal is monitoring bright hard X-ray sources and transients in 20 - 200 keV band. The iXRD consists of a CdZnTe crystal (6.45 cm2 area, 5 mm thickness), a Tungsten collimator with square holes with an opening angle of 4.26o, readout and control electronics and power circuitry, a back-shield and mechanical structures.
Some of the design elements of iXRD have been inherited from the XRD on BeEagleSat with significant improvements in terms of collecting area, X-ray background and electronic noise. In this article, the design of the iXRD is discussed in detail taking into account mechanical, electronics, control software and data handling aspects. Its expected performance is determined after ground calibration. Depending on the pixel size, the energy resolution is 4 - 7 keV at 60 keV and the minimum detectable energy is 19 - 23 keV.
A composite blockchain associated event traceability method for financial activities
Authors: Wang Junlu , Li Su , Ji Wanting , Li Dong , Song Baoyan
Published: July 2022

The existing blockchain system mostly adopts the equal mining mode. All bookkeepers (entities) record the ledger books on a single master chain. The data storage is random. Moreover, in complex or classified financial scenarios, master chain data is difficult to be correlated or stored regularly, resulting in low efficiency of storage and query; At the same time, in the existing blockchain system, event traceability is mostly only found in the source block, and the implicit association between entities cannot be identified. To solve these problems, this paper proposes a composite blockchain associated event traceability method. This method firstly constructs the blockchain composite chain storage structure model, proposes the concept of private chain and alliance chain, and realizes the adaptive data association storage in complex or classified scenarios. Secondly, on the basis of obtaining the entity block of event source, auxiliary storage space is established to transfer storage relevant data. A query method of associated entity block based on Apriori algorithm is proposed, and the obtained traceability entity block is constructed to construct the source event association diagram, so as to describe the association relationship between event entities. Finally, a risk assessment system based on reinforcement learning is proposed to realize the risk assessment of traceability entity. Experiments show that the composite blockchain associated event traceability method proposed in this paper can reduce 60% of the storage overhead, improve 90% of the query accuracy and 50% of the security.
Fitness, body composition and metabolic syndrome score in children and adolescents: The UP&DOWN study
Authors: Sánchez-Delgado Alejandro , Pérez-Bey Alejandro , Izquierdo-Gómez Rocío , Jiménez-Iglesias José , Marcos Ascensión , Gómez-Martínez Sonia , Girela-Rejón María José , Veiga Oscar L , Castro-Piñero José
Published: July 2022

Purpose: We aimed to analyse the longitudinal association between physical fitness (PF) and body composition (BC) with metabolic syndrome score (MetS) in children and adolescents, and to elucidate whether the association between PF and MetS differs when using relativized or absolute fitness variables. Methods: A total of 188 children (86 females) and 195 adolescents (97 females) were included. Cardiorespiratory fitness (CRF) was determined by the 20-m shuttle run test and muscular fitness (MF) was determined by hand grip and standing long jump tests. Height and weight were measured, and body mass index (kg/m2) was calculated. Triceps and subscapular skinfolds were assessed to compute body fat percentage. MetS was computed from: waist circumference, systolic blood pressure, triglycerides, high-density lipoprotein cholesterol and glucose levels.Results: Relative CRF was longitudinally and negatively associated with MetS in female children (β=-0.031,p=0.025), while absolute CRF was positively associated with MetS in male children and adolescents (β=0.000,p<0.05). Relative upper and lower-body MF were longitudinally and negatively associated with MetS in female adolescents (β=-1.347,β=-0.005,p<0.05), while absolute lower-body MF was positively associated with MetS in male children (β=0.000,p=0.019). BC was longitudinally and positive associated with MetS in male children (β-ranging from 0.011-0.055,all p<0.05) and male adolescents (β-ranging from 0.011-0.046,all p<0.05).Conclusion: BC is more strongly associated with MetS than PF in children and adolescents. An optimal body weight status should be considered the main objective of health promoting programs at childhood and adolescence. Furthermore, the way of expressing the fitness variables determines the direction of the association with MetS.
P-metric: a multi-factor publication metric
Authors: Datta Dilip
Published: July 2022

Currently the h-index is a widely used metric for measuring the impacts of publications of individual authors. However, many limitations of this metric have been reported over the years since its introduction. Other proposals have also been made to overcome such limitations, but none could get a better acceptance. A new metric, namely $P$-metric, is proposed here by incorporating multiple factors, including the author-wise amount of contribution, citation count, quality of each publication, and quality of each journal from which citations are received. The P-metric will not only overcome many limitations of the existing metrics by rewarding authors separately for every individual publication and its citation count, but it is also likely to reduce drastically the number of gift and guest authors. Moreover, the P-metric with a little modification can be used to measure the impacts of journals also.
Treatment, outcome and re-vaccination of patients with SARS-CoV-2 vaccine-associated immune thrombocytopenia
Authors: Ruzicka Michael , Wurm Sonja , Lindner Lars , Dreyling Martin , von Bergwelt-Baildon Michael , Boeck Stefan , Giessen-Jung Clemens , Milani Valeria , Stemmler Hans Joachim , Subklewe Marion , Weigert Oliver , Spiekermann Karsten
Published: July 2022

Purpose:Following the emergency use authorization of BNT162b2 by the Food and Drug administration (FDA) in early December 2020, mRNA- and vector-based vaccines became an important means of reducing the spread and mortality of the COVID-19 pandemic. The European Medicines Agency labelled immune thrombocytopenia (ITP) as a rare adverse reaction of unknown frequency after vector-, but not mRNA-vaccination. Here, we report on the long-term outcome of 6 patients who were diagnosed with de-novo, vaccine-associated ITP (VA-ITP), and on the outcome of subsequent SARS-CoV-2 re-vaccinations.Methods: Patients were included after presenting to our emergency department. Therapy was applied according to ITP guidelines. Follow-up data were obtained from outpatient departments. Both mRNA- or vector-based vaccines were each used in 3 cases, respectively.Results:In all patients, the onset of symptoms occurred after the 1st dose of vaccine was applied. 5 patients required treatment, 3 of them 2nd line therapy. All patients showed a complete response eventually. After up to 359 days of follow-up, 2 patients were still under 2nd line therapy with thrombopoietin receptor agonists. 5 patients have been re‑vaccinated with up to 3 consecutive doses of SARS-CoV-2 vaccines, 4 of them showing stable platelet counts hereafter. Conclusion:Thrombocytopenia after COVID-19 vaccination should trigger a diagnostic workup to exclude vaccine-induced immune thrombotic thrombocytopenia (VITT) and, if confirmed, VA-ITP should be treated according to current ITP guidelines. Re-vaccination of patients seems feasible under close monitoring of blood counts and using a vaccine that differs from the one triggering the initial episode of VA-ITP.
Controlled Pollination to Assess Intraspecific Compatibility Among Passiflora incarnata Genotypes from Different Provenances
Authors: Stafne Eric T.
Published: July 2022

Passiflora incarnata L., commonly known as maypop, is a wild passion fruit native to many areas of the eastern and southern United States where the climate ranges from subtropical to temperate. Although P. incarnata has had little attention paid to it for breeding purposes, it could be used in breeding for fruit production and possibly contribute cold hardiness genes in combination with other Passiflora species. The study was performed in 2018, 2019, and 2021 at the Mississippi State University South Mississippi Branch Experiment Station in Poplarville, MS, United States. Passiflora propagules were collected from various locations: Florida (FL), Illinois (IL), Mississippi (MS), Missouri (MO), and Oklahoma (OK). Of the 122 flowers across the five P. incarnata genotypes from differing locations, none of them produced a fruit or had any indication of successful or partially successful fertilization when selfed, indicating strong self- incompatibility. If self-compatibility does exist in nature, it is likely to be rare. However, certain combinations of P. incarnata from different locations produced successful fruiting, including IL × MO (52% success), FL × MO (85%), FL × OK (80%), MS × OK (40%), MO × IL (50%), MO × OK (40%), and OK × MO (80%). The differences across provenances show that incompatibility exists within P. incarnata but can depend on location. Overall, fruit weight, fruit size, and soluble solids content measured in this study were similar to and, in some cases, greater than those previously reported. These differences help to illustrate the diversity within P. incarnata and the still-untapped potential for breeding improvements. The problem of self-incompatibility is complex and there is much to learn about how Passiflora species, especially P. incarnata, function. Much of the U.S. domestic market is not familiar with passion fruit, especially as a table fresh product. This could be a barrier to adoption, but it could also prove to be an opportunity to create a niche within the present market and expand it. Although maypop fruit quality is not equal to that of Passiflora edulis Sims, selecting superior wild genotypes with desirable attributes to be used in future intra- and interspecific breeding is possible based on the results of this study.
Evaluation of F1 Hybrid Tomato Cultivars for Earliness, Fruit Size, and Yield Using Diallel Analysis1
Authors: Gibrel Gomaa , Boe A. A. , Simpson W. R. , Everson D. O.
Published: July 2022

Twelve cultivars and one breeding line of tomatoes, (Lycopersicon esculentum Mill.) which varied in maturity from early to late cultivars, were crossed in a diallel to estimate general and specific combining ability for earliness, fruit size, and yield using Griffing's method II, model II. General combining ability mean squares for earliness at 3 stages expressed as growing degree days (GDD) (10–32°C); and for number of days were larger than specific combining ability mean squares except for the index of first flowering stage to first fruit set. Days from seeding to first flowering and of first fruit set to first ripe fruit were positively correlated with each other and with total earliness. However, days from first flowering to first fruit set was not correlated either with the period from first fruit set to first ripe fruit or with total earliness. Fruit sizes, measured at the 3 different times were positively correlated with each other and with overall average size. A positive correlation resulted between the September 1st and October 1st yields and total yield. There was no significant correlation between fruit size and yield. General and specific combining ability mean squares were estimated on August 1st, September 1st, and October 1st for fruit size and yield. Broad sense heritability estimates were high and narrow sense heritability estimates were low, for both fruit size and yield.
Effects of Mechanical and Hand Pruning, Tree Spacing, and Limb Bending on Tree Development and Yield of Hedgerow ‘Delicious’ Apples on Mailing Merton 106 Rootstock1
Authors: Dozier W. A. , Carlton C. C. , Short K. C.
Published: July 2022

A combination of mechanical and hand pruning each year from 1971-1976 reduced pruning time over that of hand pruning alone for ‘Delicious’ apple (Malus domestica Borkh.). Yield was not significantly affected by pruning method with one exception in 1975. The use of the mechanical pruner destroyed the framework of the tree by inducing a thick canopy and reducing light penetration. Yield was increased by limb positioning at both the 2.3- and 3.0-m spacings. In 1974, higher yields were obtained with the 1.5-m spaced trees and in 1979 with the 3.0-m spaced trees. Average fruit weight was less for the 1.5-m spaced trees than for the 3.0-m spaced trees.
“WE ARE ALL MIGRANT WORKERS”: COMMONALITY OF BANGLADESHI MIGRANTS’ EXPERIENCES IN SINGAPORE AMIDST COVID-19
Authors:   School of Social and Health Science, James Cook University, 149 Sims Drive, Singapore 387380, Chattoraj Diotima
Published: July 2022

The number of COVID-19 infections in Singapore has increased dramatically since January 2020, with tens of thousands of cases linked to clusters in migrant workers’ (MWs) dormitories. The government planned to isolate the dormitories, conduct COVID-19 tests regularly, and relocate symptomatic individuals into quarantine facilities in order to combat the spread. Despite this, the majority of them were locked in their dormitories, living in tight conditions where social distancing is a myth. This research explores how COVID-19 has impacted the lives of these workers in several ways and illustrates the experiences these migrants have during the pandemic. The emphasis is on low-skilled workers from Bangladesh, who are vulnerable to COVID-19 in a variety of ways. This study used the theory of commonality to explain the diverse experiences of Singapore employees. The data demonstrate the shared hardships of commonality they accepted during COVID-19. Apart from their families, they face a life of uncertainty and anguish in the dorms, stating that commonality is felt and embodied individually while collectively negotiated and enacted. Despite the fact that their lives are filled with uncertainty and worry, they are happy and comfortable in Singapore because of how the government has taken care of them during times of crisis.
COVID-19 AND THE ROHINGYA REFUGEES IN BANGLADESH: SOCIOECONOMIC AND HEALTH IMPACTS ON WOMEN AND ADOLESCENTS
Authors:   Department of Economics, Rabindra University, Bangladesh, Shahjadpur, Sirajganj 6770, Bangladesh, Kumar Bezon ,   BK School of Research, Shahjadpur, Sirajganj 6770, Bangladesh, Pinky Susmita Dey ,   Chittagong Medical College & Hospital, Chattogram 4203, Bangladesh,   BK School of Research, Shahjadpur, Sirajganj 6770, Bangladesh, Pulock Orindom Shing ,   Chittagong Medical College & Hospital, Chattogram 4203, Bangladesh, Kamal Raihana Sayeeda ,   BRAC Institute of Governance and Development, Dhaka 1212, Bangladesh, Aziz Rashenda ,   Department of Public Health, North South University, Bashundhara, Dhaka 1229, Bangladesh,   BK School of Research, Shahjadpur, Sirajganj 6770, Bangladesh
Published: July 2022

COVID-19 has exacerbated the existing crisis that the vulnerable refugee population faces. More than a million Rohingya refugees live in Bangladesh. COVID-19 has affected both males and females. It is critical to understand how this population group is coping during this trying period. They are constituted by 52% women and 55% adolescents. The socioeconomic and physiological repercussions of the pandemic on the Rohingya people are contextualised in this study. The socioeconomic and health impacts of COVID-19 on Rohingya women and adolescents in Bangladesh are investigated. Because of the restrictions imposed, over 63% of Rohingya adolescent females suffered from food scarcity. The vast majority of respondents (87%) stated that they had reduced their meal frequency, resulting in a protein deficiency. Since their arrival in Bangladesh, they have had limited access to medical and educational facilities. The pandemic has further exacerbated the situation. Girls are more vulnerable to sexual and gender-based abuse, early marriage, school dropout, and pregnancy. This research aims to add to existing knowledge on refugees, Rohingya, women, and adolescents.
Impact of Wheat Cultivars on Establishment and Suppression of Summer Annual Weeds1
Authors: Wicks G. A. , Ramsel R. E. , Nordquist P. T. , Schmidt J. W. , Challaiah
Published: July 2022

Differences in weed interference among winter wheat (Triticum aestivumL.) cultivars have been observed in farmer fields. Identifying cultivars that are more competitive would be useful in weed control programs. Twenty cultivars of winter wheat were grown with spring germinating weeds during 1979 and 1980 and eight cultivars were grown in 1981 at North Platte, NE on a Typic Argiustoll soil. Cultivars included semi‐dwarf through normal statured types and were adapted to a wide geographic area of the Central Great Plains. ‘Lancota’ selections (NE 78939, NE 78906, NE 78895, NE 78892, and NE 78925) and sister lines NE 78742 and NE 78743 were good weed competitors. ‘Centurk 78’, ‘Buckskin’, ‘Vona’, and ‘Sage’ were intermediate, while ‘Homestead’ and several lines with Homestead germplasm were relatively poor annual weed competitors. Several cultivars that were 73 to 78 cm tall were poor competitors with weeds, while most cultivars that were 83 cm or taller were good competitors. NE 78742 (75 cm) and NE 78743 (72 cm) were among the shortest cultivars but were among the best in competitiveness with weeds. Cultivar selection can reduce summer annual weed growth in winter wheat
Timing Corn Forage Harvest for Bunker Silos
Authors: Cox W. J. , Cherney J. H.
Published: July 2022

Dairy producers with large operations have switched from upright to bunker silos so they begin corn (Zea mays L.) forage harvest at 300 g kg−1 instead of 350 g kg−1 dry matter (DM) content. Three hybrids were harvested at average DM contents of 295, 310, and 350 g kg−1 to compare DM yield and forage quality of corn forage typical of bunker and upright silos. Hybrid and DM content did not have interactions for DM yield and forage quality characteristics. The DM content at harvest did not affect DM yield (14.6, 15.0, and 15.1 Mg ha−1 at 295, 310, and 350 g kg−1, respectively). As DM content increased, neutral detergent fiber (NDF) declined (469, 447, and 417 g kg−1, respectively), but NDF digestibility (657, 632, and 631 g kg−1) and crude protein (78, 73, and 72 g kg−1) declined only from 295 to 310 g kg−1 As DM content increased, milk per megagram, a forage quality index, increased (1622, 1699, and 1764 kg Mg−1 respectively), but in vitro true digestibility (IVTD) increased (839, 835, and 847 g kg−1), only from 310 to 350 g kg−1 Calculated milk yields differed at DM contents of 295 (24380 kg ha−1) vs. 350 g kg−1 (26947 kg ha−1) but not at 310 g kg−1 (25727 kg ha−1). Results from this study indicate that dairy producers with bunker silos do not compromise DM and calculated milk yields, despite somewhat lower forage quality, if they begin harvest at 310 g kg−1 DM content.
Abscisic Acid Spray on Sunflower Acts Differently under Drought and Irrigation Conditions
Authors: Hussain S. , Ma B. L. , Saleem M. F. , Anjum Shakeel A. , Saeed A. , Iqbal J.
Published: July 2022

Appropriate use of abscisic acid (ABA), a well‐known plant growth regulator, could be beneficial to crop production under certain environmental conditions. A field experiment was conducted in both 2008 and 2009 to determine the appropriate level of ABA and the growth stages at which sunflower (Helianthus annuus L.) are sensitive to exogenous application of ABA. Sunflowers grown in fully irrigated plots or in plots receiving limited irrigation were sprayed with 0, 5, and 10 μM ABA at the bud initiation or early flowering. Growth and yield of sunflower were severely reduced (P < 0.05) by limited irrigation. When irrigation was withheld at the bud initiation, foliar spray of ABA at 5 μM increased (P < 0.05) crop growth rate (6%) and leaf area index (16%) at flowering, and total biomass production (14%), leading to increased achene yield by up to 27% and oil yield by 24%. However, achene and oil yields were often reduced by ABA treatment under drought‐free conditions. More improvement of ABA application in growth and yield was observed when drought occurred at bud initiation stage, and when ABA was applied to drought‐prone sunflower at 5 μM than at 10 μM concentrations. Our study suggests that timely application of 5 μM ABA could improve sunflower productivity under drought‐prone conditions.
ESTIMATION OF SERUM CRP,FERRITIN,D-DIMER,LACTATE DEHYDROGENASE IN COVID 19 PATIENTS
Authors:   Associate Professor, Department of Biochemistry Government Medical College, Kadapa., Venkateswarlu K. , Vasundhara Devi Ilaka ,   Associate professor, Department of Biochemistry, Andhra Medical College, Visakhapatnam., Swaroopa Rani R.S. ,   Assistant Professor, Department of Biochemistry Guntur, Medical College, Guntur., P. Srirekha ,   Assistant Professor, Department of Biochemistry Kurnool Medical College, Kurnool.
Published: July 2022

Background: Severe COVID-19 illness is associated with intense inflammation, leading to high rates of thrombotic complications that increase morbidity and mortality . New laboratory tests capable of differentiating between severe and non-severe cases and appropriate management of COVID-19. Aims and Objective: Aim to investigate the association between several biomarkers, including serum C-reactive protein (CRP), Lactate Dehydrogenase, D-dimer, and serum ferritin, and COVID-19 severity. Methodology: The study was conducted during September 2020-Dec-2021 among Covid patients confirmed by RT-PCR and admitted to Government general hospital.LDH was estimated in semi-auto analyzer by UVkinetic method and serum Ferritin, CRP, D-dimer was estimated by Immunoturbidometric method. Results: Amongst 1200 SARS-CoV-2 patients, Elevated CRP levels were seen in 88 percent of patients, D-Dimer in 94 percent of patients, Ferritin in 83 percent of patients, LDH in 93 percentof patients. Discussion: Elevated serum CRP, D-dimer, and serum ferritin levels were associated withan increased poor outcome that comprises mortality, severe COVID-19, ARDS, and the need for ICU care in patients with COVID-19.
Características sociodemográficas, laborais, estilo de vida e estado nutricional associados à baixa concentração de HDL-c de siderúrgicos
Authors: Viana Michell Vetoraci , Viana Danyela Gomes , Cattafesta Monica , Ferraz Almir Franca , Salaroli Luciane Bresciani , Andrade Douglas Roque , Junior Aylton Figueira
Published: July 2022

Objetivo: Avaliar as características sociodemográficas, laborais, estilo de vida e estado nutricional associados à baixa concentraçãode HDL-c de siderúrgicos. Método: Trata-se de uma investigação observacional, analítica e transversal que avaliou as variáveis independentes(características sociodemográficas, laborais, estilo de vida e estado nutricional) associados à baixa concentração de HDL-c de trabalhadores siderúrgicos, considerando o universo amostral de 4.500 colaboradores de uma empresa do setor siderúrgico, localizada no município de Vitória – ES/Brasil. Resultados: Após as análises múltiplas, identificou-se que com o aumento da idade, há relação aumentada de mais de uma vez de chance em HDL-c abaixo (OR 1,11, IC95% 1,06 – 1,15, p<0,001), enquanto trabalhar 12 horas ou mais aumenta em 26% a chances de ter HDL-c abaixo do recomendado (OR 0,26, IC95% 0,08 – 0,81, p=(0,020).Ao avaliar os hábitos de vida, constatou-se que os colaboradores insuficientemente ativos apresentaram 3,52 vezes mais chances de HDL-c abaixo do recomendado (OR 3,52, IC95% 1,40 – 8,89, p=0,008). Conclusão: Os resultados do presente estudo permitem concluir que o baixo índice de HDL-c em colaboradores do setor siderúrgico associa-se a condicionantes multifatoriais, com destaquepara a idade acima dos 40 anos, tempo de trabalho acima de 12 horas/dia e inatividade física. Embora poucos estudos tenham tratado do tema relacionado ao trabalhador siderúrgico, sugerimos programas que promovam aumento da atividade física comointervenção para prevenção, promoção da saúde, buscando melhorar os valores de HDL-c, e consequentemente, diminuir os riscos associados à saúde de colaboradores, principalmente a inatividade física.
O Coração da Mulher: Tecnologia educativa para prevenção de doenças cardiovasculares em mulheres menopausadas
Authors: Albuquerque Queiroz Camila , De Azevedo Ponte Keila Maria , Teixeira de Sousa Santos Lucas , Sousa da Ponte Hermínia Maria
Published: July 2022

Objetivou-se averiguar a contribuição de uma Tecnologia Educativa (TE) para prevenção de Doenças Cardiovasculares (DCV) em mulheres na menopausa. Trata-se de uma pesquisa participante e exploratória descritiva, com abordagem qualitativa realizada denovembro de 2016 a março de 2017 com mulheres no climatério em Sobral-Ceará. A tecnologia educativa denominada o Coração da Mulher contribuiu de forma lúdica no aprendizado, compreensão, conscientização, conhecimentos sobre as DCVs e olhar holístico à sua própria saúde. Na avaliação pelas participantes houve uma ótima adesão em relação à TE.
SOCIOLOGICAL ASPECT IN THE CONTENT OF THE MODERN HYBRID WARFARE
Authors: Panfilov Oleksandr , Savchenko Olga
Published: July 2022

The goal of the article is to study the essence of hybrid warfare within the sociological aspect. The paper focuses on the essence of “soft power” as the basis of a certain social technology that comprises the system of means and methods of purposeful action on social processes, the life of people under a hybrid war. The essence of organisational weapons is highlighted in the sociological context. It is noted that organisational weapons are based on special technologies of organisational management reflexion, which are aimed at representatives of social groups and institutions who are directly or indirectly involved in the long-term and short-term regulation of the behaviour of the population. The mechanism of the organizational weapons impact on the value and semantic models of social reality perception is determined.
PANDEMIC AS A CHALLENGE: FEATURES OF PHILOSOPHY IN EMERGENCY CONDITIONS
Authors: Kovalenko Inna , Meliakova Yuliia , Kalnytskyi Eduard
Published: July 2022

The article explores the specifics of philosophizing in the context of the COVID-19 pandemic. Various versions of comprehension of a new reality, expressed by famous thinkers, are analyzed. The specificity of social and personal life is shown in the context of the theory of viral modernity in combination with the experience of global digital control. The modern pandemic situation has been rethought as an extraordinary event, which, in contrast to the temporality of familiar experience, radically changes the sense of time in the conditions of daily life of covid.
THE LAW BETWEEN ECOLOGY AND OEKOUMÈNE: FOR A PUBLIC NORMATIVITY
Authors: Melkevik Bjarne
Published: July 2022

The article has a philosophical framework of some of the concerns raised by the degradation of the environment and even the current global environmental crisis. He does this by updating the idea of the «oekoumene» to present his reasons and in particular to clarify our way of thinking about our relationship to the «environment» and «nature». Emphasis is placed on the implications, both practical and theoretical, of the choice of the perspective of the œkoumene, with regard to the paradigm of a legal modernity in perpetual construction.
CHILEAN COLONIAL REPUBLIC 1929-1973. SCHOOL AND MAPUN-KIMUN INVISIBILIZATION OF THE MAPUCHE NATION PEOPLE
Authors: Mansilla Sepúlveda Juan Guillermo
Published: July 2022

The article presents the experience of the Chilean schools’ activities in the post-occupation period in Mapuche. The features of the state educational politics are reconstructed within the framework of asymmetric intercultural relations. It is shown that the school became an active agent in achieving monoculturalism and the introduction of Western knowledge which did not fulfill its mission: the people of Mapuche managed to survive when the attempts of control and conquest were taken; today, there is also an opposing cultural resistance to the state, which operates the logic of excluding ethnic and linguistic diversity.
Indoquinoline Alkaloids from Sida rhombifolia (L.) (Malvaceae) and Antimicrobial Evaluation of Cryptolepinone Derivatives
Authors: Oliveira Micaelly , Chaves Otemberg , Cordeiro Laísa , Gomes Ayala , Fernandes Diégina , Teles Yanna , da Silva Tania , Freire Kristerson , Lima Edeltrudes , Agra Maria de Fátima , de Souza Maria de Fátima
Published: July 2022

Considering the relevance of natural products to the development of new drugs, this study focuses on the species Sida rhombifolia (L.), Malvaceae, widely used as a traditional remedy in several countries. The species is used to treat several diseases such as fevers, skin diseases, stomach pain, diarrhea, gum infection, conjunctivitis, urinary infections and inflammation. Many researchers around the word have investigated its pharmacological potential, and many uses have been confirmed. In spite of that, the phytochemical composition of its extracts is still poorly investigated. This research aims to make advances on the understanding of the constituents of S. rhombifolia identifying its alkaloidal compounds using ultra-high performance liquid chromatography coupled to mass spectrometry (UPLC-QTOF-MS/MS). By analyzing its alkaloidal fraction it was possible to identify: 11-cryptolepine carboxylic acid (1), cryptolepine (2), quindoline (3), 11-methoxyquidoline (4), quindolinone (5), cryptolepinone (6), and 11-quindoline methyl ester (7). The alkaloids 1 and 7 are being reported for the first time from Sida genus. Based on the antimicrobial potential of cryptolepinone-type alkaloids, we prepared by semi-synthesis two cryptolepinone derivatives: 10-methylcryptolepinone (8) and the unreported compound 10-ethylcryptolepinone (9). Both derivatives were tested against fungae and bacterial strains and 10-methylcryptolepinone (8) showed strong activity against Cryptococcus neoformans, Candida albicans, C. tropicalis, Aspergillus fumigatus and A. flavus.
Water quality reliability based on an improved entropy in a water distribution system
Authors: Wang Yumin , Zhu Jianguo , Zhu Guangcan
Published: July 2022

In this paper, information entropy was proposed to measure water quality reliability in a water distribution system (WDS), which had been applied to evaluate hydraulic reliability in the WDS. In the water quality reliability evaluation, residual chlorine is a representative of water quality, and a first-order decay model was usually adopted. The water quality reliability (R) based on water quality entropy (WQE) and improved water quality reliability (Rd) based on improved water quality entropy (IWQE) were proposed and compared for three networks. The method was developed based on the EPANET toolkit and MATLAB environment. The results indicated that flow entropy (FE) is strongly related to WQE, and improved flow entropy (IFE) is also strongly related to IWQE. In addition, Rd can reflect the effect of pipe velocity, whereas R can only reflect the effects of pipe flow and the WDS layout. The novelty of this paper is to develop the entropy with consideration of the pipe velocity to measure water quality liability as a surrogate index, which can reduce the calculation load and can be applied to a nonlinear system. The proposed water quality reliability evaluation method based on information entropy can help design, analyze, and improve the water quality in the WDS.
Assessing the impact of climate change in the wheat–maize cropping system across the Huang–Huai–Hai Plain under future climate scenarios
Authors: Shirazi Sana Zeeshan , Mei Xurong , Liu Buchun , Liu Yuan
Published: July 2022

General circulation models suggest that changes in climatic parameters will have an effect on food production globally. Therefore, this study assessed the impact of climate change on wheat–maize rotation areas in the Huang–Huai–Hai Plain (3H Plain). The projections generated suggest an increase in precipitation during the wheat growth period (WGP) by 1.33–4.16% (2.6–8.3 mm) and 3.13–8.16% (6.2–18.0 mm) under RCP4.5 and RCP8.5, respectively, relative to the base period (1981–2016). Across the 3H Plain, the mean temperature during the WGP is projected to increase between 1.17–1.21 and 1.17–1.28 °C under RCP4.5 and RCP8.5, respectively. The projections during the maize growth period (MGP) indicate an increase in the temperature between 1.29–1.92 and 1.84–2.08 °C under RCP4.5 and RCP8.5, respectively. During the MGP, precipitation is also projected to increase by 7.41–9.73% (33.6–45.1 mm) and 6.63–14.78% (29.8–72.7 mm) under RCP4.5 and RCP8.5 scenarios, respectively. For each 1% change in climatic factors, the comprehensive effect on yield was projected to be 0.65 and 0.58% for wheat and −1.08 and −1.11% for maize, under RCP4.5 and RCP8.5, respectively, when other factors were kept constant. The change in water resources will be insignificant during the WGP and more pronounced during the MGP. The study provides an overview of changes in meteorological parameters and scientific evidence for climate change adaptation in the wheat–maize cropping system.
El desafío del arquitecto en la protección de los bosques del Perú
Authors: Takahashi Luis
Published: July 2022

La gran diferencia entre los bosques tropicales amazónicos y los bosques de climas templados y fríos es que en los primeros existen miles de especies de árboles que conviven en un medio ecológico complejo y variado, mientras que en los segundos hay pocas especies que forman bosques homogéneos y fáciles de manejar. La gran variedad de especies forestales presentes en los bosques tropicales inicialmente se considera como un obstáculo, esto debido a su complicada extracción, lo cual, junto con el uso de maderas con propiedades disímiles y el tratamiento industrial que esto implica, lleva a afirmar de forma equivocada que este bosque no sirve, especialmente porque la mayoría de las especies tropicales son muy diferentes a las de los bosques templados, por lo tanto, se desprecian y se destruyen. En realidad, esa gran diversidad arbórea se convierte en una bendición al tener árboles que presentan maderas con propiedades naturales aptas para muchísimos usos. La experiencia de los últimos 40 años demuestra que las especies forestales antes ignoradas hoy se exportan y son consideradas entre las más valiosas. En el presente artículo se señala que la clave de la salvación del bosque es otorgarle el valor económico a todas las especies, con lo cual el rol del arquitecto promotor del uso de la madera en construcción (no decoración) es esencial.
Comparative Study of Binding Pockets in Human CYP1A2, CYP3A4, CYP3A5, and
CYP3A7 with Aflatoxin B1, a Hepato-Carcinogen, by Molecular Dynamics Simulation
& Principal Component Analysis
Authors: Saba Nikhat , Seal Alpana
Published: July 2022

Background:

Aflatoxin B1 is a harmful hepatocarcinogen which is metabolized in our body by Cytochrome
P450 enzymes, namely CYP1A2, CYP3A4, CYP3A5, and CYP3A7, into toxic (exo-8, 9-epoxide) and nontoxic
(AFQ1, endo-epoxide) products. We have found from the literature that due to cooperativity, the rate of metabolic
reactions increases in CYP1A2 and CYP3A4 involving more than one site of proteins to form two products at a
given time, whereas the interaction of CYP3A5 and CYP3A7 is still unknown. Our work aims to study these four
enzymes with AFB1 based on binding site pocket characterization and to find the probable resultant products at each
binding site.

Methods:

We used computational approaches like homology modeling, molecular docking to form mono and double
ligated systems, molecular dynamic simulations to analyze the potential energies (vdW & electrostatic), PCA,
RMSF, and residue-wise interactions at the active as well as allosteric sites of these four enzymes.

Results:

We found that CYP1A2, CYP3A4, and CYP3A5 were more hydrophobic at the first site and may induce
epoxidation reaction to form toxic products, whereas the second site would be expected to be more polar and comprising
charged interactions, thus enhancing non-toxic hydroxylated products. However, in CYP3A7, the first site
favors hydroxylation, whereas the second site is involved in higher hydrophobic interactions.

Conclusion:

Thus, in the fetus where AFB1 is metabolized only by CYP3A7, a lower concentration of toxic metabolites
will be expected, while in adults exhibiting CYP1A2, CYP3A4 and CYP3A5 may increase the concentration of
the toxic metabolites due to the combined effect of these enzymes, consequently increasing liver toxicity. We believe
that AFB1 binding characteristics will be helpful for medicinal chemists in the process of designing a new drug.
Application of Diffusion Tensor Imaging Based on Automatic Fiber Quantification in Alzheimer's Disease
Authors: Yu Bo , Ding Zhongxiang , Wang Luoyu , Feng Qi , Fan Yifeng , Xu Xiufang , Liao Zhengluan
Published: July 2022

Background:

Neuroimaging suggests that white matter microstructure is severely affected in Alzheimer's disease (AD) progression. However, whether alterations in white matter microstructure are confined to specific regions and whether they can be used as potential biomarkers to distinguish normal control (NC) from AD are unknown.

Methods:

In this cross-sectional study, 33 cases of AD and 25 cases of NC were recruited for automatic fiber quantification (AFQ). A total of 20 fiber bundles were equally divided into 100 segments for quantitative assessment of fractional anisotropy (FA), mean diffusivity (MD), volume and curvature. In order to further evaluate the diagnostic value, the maximum redundancy minimum (mRMR) and LASSO algorithms were used to select features, calculate the Radscore of each subject, establish logistic regression models, and draw ROC curves, respectively, to assess the predictive power of four different models.

Results:

There was a significant increase in the MD values in AD patients compared with healthy subjects. The differences were mainly located in the left cingulum hippocampus (HCC), left uncinate fasciculus (UF) and superior longitudinal fasciculus (SLF). The point-wise level of 20 fiber bundles was used as a classification feature, and the MD index exhibited the best performance to distinguish NC from AD.

Conclusion:

These findings contribute to the understanding of the pathogenesis of AD and suggest that abnormal white matter based on DTI-based AFQ analysis is helpful to explore the pathogenesis of AD.
Predicting COVID-19 Severity Integrating RNA-Seq Data Using Machine
Learning Techniques
Authors: Bajo-Morales Javier , Castillo-Secilla Daniel , Herrera Luis Javier , Caba Octavio , Prados Jose Carlos , Rojas Ignacio
Published: July 2022

A fundamental challenge in the fight against COVID -19 is the development of reliable and accurate tools to predict disease progression in a patient. This information can be extremely useful in distinguishing hospitalized patients at higher risk for needing UCI from patients with low severity. How SARS-CoV-2 infection will evolve is still unclear.

Methods:

A novel pipeline was developed that can integrate RNA-Seq data from different databases to obtain a genetic biomarker COVID -19 severity index using an artificial intelligence algorithm. Our pipeline ensures robustness through multiple cross-validation processes in different steps.

Results:

CD93, RPS24, PSCA, and CD300E were identified as a COVID -19 severity gene signature. Furthermore, using the obtained gene signature, an effective multi-class classifier capable of discriminating between control, outpatient, inpatient, and ICU COVID -19 patients was optimized, achieving an accuracy of 97.5%.

Conclusion:

In summary, during this research, a new intelligent pipeline was implemented with the goal of developing a specific gene signature that can detect the severity of patients suffering COVID -19. Our approach to clinical decision support systems achieved excellent results, even when processing unseen samples. Our system can be of great clinical utility for the strategy of planning, organizing and managing human and material resources, as well as for automatically classifying the severity of patients affected by COVID -19.
Adherence to Self-Care Behaviors and Associated Factors among Adult Heart Failure Patients Attending Chronic Follow-Up Care at Jimma University Medical Center, Southwest Ethiopia
Authors: Mulugeta Temesgen , Duguna Desalegn , Bekele Azmeraw , Umeta Belachew
Published: July 2022

Background:

Optimal outcomes and quality of life in patients with heart failure (HF) depend on effective self-care activities. However, patients may experience difficulties, and their performance may be inconsistent.

Aim:

To determine the level of adherence to self-care behaviors and associated factors among adult HF patients attending chronic follow-up care at Jimma University Medical Center (JUMC).

Methods:

A cross-sectional study was conducted between August and September 2021. Data were collected through face-to-face interviews and by reviewing patients’ medical records. The collected data were analyzed using SPSS version 25 and the findings were presented in frequency, percentage, mean (SD), and median (IQR). Multivariate logistic regression was performed to determine factors associated with adherence to self-care behaviors. Odds ratios with 95% confidence intervals and p-values were used to report the findings.

Results:

Out of 266 HF patients, 50.0% had good adherence towards self-care behavior recommendations. The highest following recommendation was taking medication as prescribed (75.5%), followed by a dietary recommendation of a low-salt diet (45.2%). Participants who could not read and write (adjusted odds ratio (AOR) = 0.30 (95% confidence interval (CI) 0.13, 0.71), P = 0.006), had an illness duration greater than or equal to ten years (AOR = 0.31 (95% CI 0.12, 0.82), P = 0.02), in the NYHA class II HF (AOR = 0.33 (95% CI 0.15, 0.73), P = 0.007) were negatively associated with good adherence to self-care behavior recommendations.

Conclusion:

In this study, only half of the respondents had good adherence to self-care behaviors. Lower educational level, longer illness duration, and NYHA class II HF were predictors of poor adherence to self-care. Therefore, nurses should devise strategies to counsel or educate the HF patients on self-care practice recommendations, particularly patients with a lower education level and who lived longer with HF.
Adjunct Therapy of Zinc Supplementation Increases Immunological Response in HIV-Infected Patients: A Systematic Review and Meta-Analysis
Authors: Sindhughosa Dwijo Anargha , Somia I Ketut Agus , Merati Ketut Tuti Parwati , Suryana Ketut
Published: July 2022

Introduction:

Malnutrition greatly accelerates the impairment of immune function among HIV-infected patients. Zinc deficiency is often found in people living with HIV/AIDS, affecting their immune function. Several studies have evaluated the effect of zinc in HIV-infected patients, including CD4+ T-cells. However, the results have varied. This review aimed to evaluate the effect of zinc supplementation in HIV patients, particularly its effect on CD4+ T-cells count.

Methods:

Relevant publications were obtained from PubMed database, Google Scholar, COCHRANE, and Science Direct. The primary outcome was CD4+ T-cells count, while the secondary outcomes were viral load and zinc levels. Year of publication, type of study, population, doses of zinc given, duration of zinc administration, sample size, age, and baseline CD4+ T-cells counts were also obtained and reported. Quantitative data from the publications were analyzed using a fixed-effect model or a random-effect model.

Results:

We evaluated 13 full-text articles on zinc supplementation in HIV-infected patients, involving 802 subjects for the experiment group and 742 subjects for the control group. Overall, zinc supplementation, whether as zinc supplementation-only or prepared as multiple micronutrient or multivitamin preparation, increases CD4+ T-cells counts by 33.14 cells/mm3 (p =0.02; 95% CI: 6.09 to 60.19), irrespective of age. Subgroup analysis revealed CD4+ T-cells counts also increase in patients who receive zinc supplementation-only preparation by 33.56 cells/mm3 (p = 0.04; 95% CI: 1.5 to 65.63). Zinc supplementation increases serum zinc levels with pooled mean difference of 15.41 µg/dl (p < 0.05; 95% CI: 12.77 to 18.06). However, the viral load did not significantly decrease with zinc supplementation, with a pooled mean difference of -4.02 copies/ml (p =0.7; 95% CI: -24.78 to 16.75), based on the random-effect model.

Conclusion:

Zinc supplementation in HIV-infected patients enhances immunological response, characterized by an increase in CD4+ T-cells counts. In addition, it increases zinc serum levels in HIV-infected patients, indicating the importance of zinc supplementation in this group of patients.