bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Snowpack-Hydrometeorological Sensors for Hydrogeological System Comprehension inside an Alpine Closed-Basin
Authors: Mondani Michele , Gizzi Martina , Taddia Glenda
Published: September 2022

Groundwater resource assessment and forecasting in mountain areas requires the monitoring of two conditions, local meteorological conditions, and springs’ groundwater parameters. The reliability of the monitoring data and conditions are linked to the technical instrumentation, multiparametric probes, and sensors. This paper presents a set of attractive tools and sensors for springs’ groundwater resource monitoring and assessment in mountain basins. Data from the combination of weather station sensors with spring flow-rate instruments, installed in the alpine Mascognaz basin, can guarantee an entire understanding of how one set of parameters can affect other results, defining consequential cause-and-effect relationships. Since a large part of the Alpine groundwater bodies are exploited for drinking purposes, understanding the evolution of their rechange processes requires making the right economic and instrumental investments aimed at using them according to forecast predictions and sustainable development goals.
Development of a 16-Channel Broadband Piezoelectric Micro Ultrasonic Transducer Array Probe for Pipeline Butt-Welded Defect Detection
Authors: Li Bolun , Sun Changhe , Xin Shouchun , Luo Mingzhang , Hei Chuang , Du Guofeng , Feng Ankang
Published: September 2022

Butt welding is extensively applied in long-distance oil and gas pipelines, and it is of great significance to conduct non-destructive ultrasonic testing of girth welds in order to avoid leakage and safety accidents during pipeline production and operation. In view of the limitations of large transducer size, single fixed beam angle, low detection resolution and high cost of conventional ultrasonic inspection technologies, a 16-channel piezoelectric micro ultrasonic transducer (PMUT) array probe was developed through theoretical analysis and structural optimization design. After the probe impedance characterization, the experimental results show that the theoretical model can effectively guide the design of the ultrasonic transducer array, offering the maximum operating frequency deviation of less than 5%. The ultrasonic echo performance tests indicate that the average −6 dB bandwidth of the PMUT array probe can be up to 77.9%. In addition, the fabricated PMUT array probe has been used to successfully detect five common internal defects in pipeline girth welds. Due to the multiple micro array elements, flexible handling of each element, large bandwidth and high resolution of defect detection, the designed PMUT array probe can provide a good application potential in structural health monitoring and medical ultrasound imaging fields.
Optical Property and Stability Study of CH3(CH2)3NH3)2(CH3NH3)3Pb4I13 Ruddlesden Popper 2D Perovskites for Photoabsorbers and Solar Cells and Comparison with 3D MAPbI3
Authors: Kranthiraja Kakaraparthi , Aryal Sujan , Temsal Mahdi , Sharma Mohin , Kaul Anupama B.
Published: September 2022

Three dimensional (3D) perovskite solar cells (PSCs) are a promising candidate for third-generation photovoltaics (PV) technology, which aims to produce efficient photon conversion devices to electricity using low-cost fabrication processes. Hybrid organic-inorganic perovskites for-lmed using low-cost solution processing are explored here, which have experienced a stupendous rise in power conversion efficiency (PCE) over the past decade and serve as a prime candidate for third-generation PV systems. While significant progress has been made, the inherent hygroscopic nature and stability issue of the 3D perovskites (3DPs) are an impediment to its commercialization. In this work, we have studied two-dimensional (2D) organometallic halide (CH3(CH2)3NH3)2(CH3NH3)n−1PbnI3n+1) layered perovskites in the Ruddlesden Popper structure, represented as BA2MA3Pb4I13 for the n = 4 formulation, for both photoabsorbers in a two-terminal architecture and solar cells, given that these material are considered to be inherently more stable. In the two-terminal photo absorber devices, the photocurrent and responsivity were measured as a function of incoming laser wavelength, where the location of the peak current was correlated to the emission spectrum arising from the 2DP film using photoluminescence (PL) spectroscopy. The 2D (BA)2(MA)3Pb4I13 films were then integrated into an n-i-p solar cell architecture, and PV device figures of merit tabulated, while our 3D MAPbI3 served as the reference absorber material. A comparative study of the 3DP and 2DP film stability was also conducted, where freshly synthesized films were inspected on FTO substrates and compared to those exposed to elevated humidity levels, and material stability was gauged using various material characterization probes, such as PL and UV-Vis optical absorption spectroscopy, scanning electron microscopy and X-ray diffraction. While the PCE of the 3D-PSCs was higher than the 2D-PSCs, our results confirm the enhanced environmental stability of the 2DP absorber films compared to the 3DP absorbers, suggesting their promise to address the stability issue broadly encountered in 3D PSCs toward third-generation PV technology.
Perceived Benefit and Cost Perception Gaps between Adopters and Non-Adopters of In-Field Conservation Practices of Agricultural Producers
Authors: McCollum Calder , Bergtold Jason S. , Williams Jeffery , Al-Sudani Amer , Canales Elizabeth
Published: September 2022

Farmers’ willingness to adopt conservation practices is influenced by their perceptions of the practices. Differences in perceptions point toward potential educational and outreach strategies that may be employed to promote adoption. The purpose of this study was to assess perception gaps between adopters and non-adopters for continuous no-tillage, conservation crop rotations, cover crops, and variable-rate application of inputs. Using primary survey data from Kansas agricultural producers, we evaluated differences in perceptions regarding economic, agronomic, environmental, and management outcomes through descriptive statistic and mean separation tests. Practice adoption ranged from 29% for variable-rate application of inputs to 69% for conservation crop rotations. On average, adopters perceived increases in crop yields and net returns for each practice compared to non-adopters. Perceptions about other factors varied by practice, but perceived benefits tended to be higher for adopters. Similarly, perceived disadvantages from adoption (e.g., higher cost, increased management needs) tended to be lower among adopters. Overall, both adopters and non-adopters perceived environmental benefits from adopting conservation practices. Our findings point toward potential outreach strategies to promote conservation adoption, such as extension and outreach that share more relevant and localized economic information and build upon joint perceptions of environmental benefits of practices.
Multilevel Mixed-Effects Models to Identify Contributing Factors on Freight Vehicle Crash Severity
Authors: Park Seongmin , Park Juneyoung
Published: September 2022

Freight vehicle crashes are more serious than regular vehicle crashes because they are likely to lead to major damage and injury once they occur; therefore, countermeasures are needed. The fatality rate from freight vehicle crashes is 1.5 times higher than that of all other accidents, and the death rate from expressway freight vehicle crashes continues to increase. In this study, the ten-freight-vehicle crash severity models (the ordered logit and probit model, the multinomial logit and probit model, mixed-effects logit and probit model, random-effects ordered logit and probit model, and multilevel mixed-effects ordered logit and probit model) are used to analyze the freight vehicle crash severity factors. The model was constructed using data collected from expressways over eight years, and 13 factors were derived to increase the severity of crashes and 7 factors to reduce the severity of crashes. As a result of comparing the 10 constructed models using AIC and BIC, the multilevel mixed-effects ordered probit model showed the best performance. It is expected that it can contribute to improving the safety of freight vehicles in the expressway section by utilizing factors related to the severity of crashes derived from this study.
A Conceptual Design and Analysis of a Novel Trigeneration System Consisting of a Gas Turbine Power Cycle with Intercooling, Ammonia–Water Absorption Refrigeration, and Hot Water Production
Authors: Altun Ayşe Fidan
Published: September 2022

In this study, the performance of a novel trigeneration system with a gas turbine prime mover, an ammonia–water refrigeration system, and a hot water generation system is investigated from thermodynamic and economic standpoints. The effects of various operating conditions on energy efficiency and the levelized cost of energy are investigated. The proposed system has a production capacity of 45.4 kW power, 14.07 kW cooling rate, and 16.32 kW heat rate. The efficiency of the gas turbine cycle is 49.7%, and it becomes 83.0% after the implementation of the trigeneration system. Through combined heating, cooling, and power generation, primary energy input and the CO2 emissions will be 49% lower compared to separate production. According to the exergy analysis, the combustion chamber is the main component where the greatest exergy destruction occurs. Sensitivity analysis revealed that an increase in the ambient temperature results in a decrease in the energy utilization factor and the net power output. The LCOE of the system is around 0.02 $/kWh, whereas the unit price of the local electricity from the grid is 0.09 $/kWh. The payback period of the absorption sub-cycle is between 4 months and 4 years, depending on the annual operation time of the chiller.
Agriculture from Areas Facing Natural or Other Specific Constraints (ANCs) in Poland, Its Characteristics, Directions of Changes and Challenges in the Context of the European Green Deal
Authors: Zieliński Marek , Koza Piotr , Łopatka Artur
Published: September 2022

Increasing the European Union’s (EU) current efforts to protect the natural environment, especially in the context of protecting agricultural soils, is one of its basic challenges. The European Commission (EC) is now ready and willing to strongly strengthen protection of the natural environment. Activities are primarily supported by the European Green Deal (EGD) strategy from 2019 and its thematic strategies, as well as the currently revised Common Agricultural Policy (CAP) for 2023–2027. Further direct support for farms from Areas facing Natural or other Specific constraints (ANCs support), compensating for them at least some of the additional costs and lost income related to the difficulties for agricultural production, will be one of the most important actions of the future CAP in the context of the protection of agricultural soils. It should be added that, in recent years, all EU Member States, including Poland (in 2019), have carried out a mandatory new delimitation of ANCs according to the same rules established by the EC Joint Research Center (EC JRC) under the CAP 2014–2020. The aim of the study is to characterize the organizational situation of Polish agriculture, to indicate the direction and strength of the changes taking place in it, as well as the main determinants of its further functioning in areas (communes) with a particularly high saturation of current ANCs, as compared to other areas, with and without ANCs. It is also important to present the economic consequences and development opportunities for farms conducting agricultural production in these areas. The results of the study show the condition of Polish agriculture and changes taking place in this sector in areas with different saturation and specificity of ANCs related to challenges for environmental protection included in the EGD strategy and the current and future CAP. The research results will also provide an important basis for policymakers in undertaking effective agricultural support in ANCs and for the scientific community to develop agricultural research that can meet the most pressing challenges faced in the areas. It should be noted that the study emphasizes the significance of the new institutional economics, the postulates of which can provide solid support for the actions taken to better protect ANCs.
Sustainability with Changing Climate and Extremes
Authors: Jin Shaofei , Yang Jia , Yan Xiaodong
Published: September 2022

Climate change and extreme events are receiving increasingly more attention in the global sustainable development sphere [...]
Environmental Sustainability and Tourism—The Importance of Organic Wine Production for Wine Tourism in Germany
Authors: Szolnoki Gergely , Tafel Maximilian
Published: September 2022

Sustainable aspects of wine tourism have become very important in recent years. The environmental sustainability of wineries, in the form of organic certification, is not a direct component of wine tourism but can nevertheless play a significant role in visiting a winery. Semi-structured in-depth interviews with 32 wineries from 10 different German wine growing regions were conducted to analyze the tourism appeal, the importance of organic certification, and the future development of organic wine tourism from the producers’ points of view. The results show that there is certain evidence for using organic certification as a unique selling point, but it appears that wineries are not fully exploiting these possibilities. This study could help organic wineries to get a transparent picture of the current situation in terms of relevance and to break down communication barriers in order to establish contact with potential visitors to the winery.
Role of Biogas in Achieving Sustainable Development Goals in Rohingya Refugee Camps in Bangladesh
Authors: Chowdhury Hemal , Chowdhury Tamal , Sharifi Ayyoob , Corkish Richard , Sait Sadiq M.
Published: September 2022

Energy is an essential need of people; however, people living in displacement settings are often deprived of this basic need. Connecting refugee camps through the main grid is challenging due to their locations. Biogas is an energy source that can be implemented to address the energy need of refugee camps. Implementation of biogas technology can help to reach sustainable development goal-7 (SDG 7) and its synergies in refugee camps. Therefore, in this study, the contribution of biogas in achieving sustainable development goals is presented to address the current gap in the literature. For this, Rohingya refugees in Bangladesh were considered as a case study. The waste situation in Rohingya refugee camps is highlighted and considered. Generated biogas from the organic fraction municipal solid (OFMSW) was used to determine the LPG cylinder reduction potential in Rohingya refugee camps. Approximately 497,587 LPG cylinders can be replaced if biogas is used in cooking activities. Moreover, compared to wood fuel, biogas used in cookstoves emits 85% less greenhouse gas. This study underlines the importance of further research to determine the prospective use of biogas in clean cooking in refugee camps.
Exploring the Needs of Elderly Care in China from Family Caregivers’ Perspective via Machine Learning Approaches
Authors: Wang Ying , Luo Peiwen
Published: September 2022

With the rapid graying of China’s population, ensuring and improving the quality of life for Chinese elderly people has become an urgent issue. This paper explores the needs of elderly people in China from the perspective of their caregivers by applying machine learning approach upon social media posts related to elderly care and subsequently put forward strategies with respect to data mining findings. We obtain more than thirty thousand texts from the Douban discussion group named “One-Child Parent Retirement Exchange”; Latent Dirichlet Allocation (LDA) model is employed to extract topic and words, to analyze and categorize text into relevant elderly care. This study then utilizes SnowNLP module upon previous outcome to appraise the emotional bias of the caregivers. Our finding points out that the essential needs of Chinese elderly people are mental health needs, information needs and intergenerational needs; the emotional bias of children in supporting their parents was generally negative. At the end, our paper subsequently suggests strategies to satisfy the primary elderly caring needs while at the same time alleviating caregivers’ pressure.
Indicators for the Circular City: A Review and a Proposal
Authors: Paoli Federica , Pirlone Francesca , Spadaro Ilenia
Published: September 2022

The theme of the circular city is currently much debated in the literature as a possible strategy for achieving sustainability in urban areas. However, as a recent development it still has many features in the making, one of the most important being the issue concerning monitoring and the tool through which to achieve it. In the paper, therefore, the “indicator” tool is explored in depth. Metrics represent a fundamental and complex aspect that is foundational to measuring and quantifying the progress of results achieved with respect to the goals set. Currently, most existing indicators are associated with specific aspects of the circular economy; there have been few examples of indicators designed to assess the circularity of an entire city. The paper aims to identify priority themes and describe a set of indicators to be used at the urban level. In the absence of an established reference frame, themes and indicators were identified through a methodology starting with an extensive literature search and careful analysis, including statistical analysis, of the scientific literature as well as international and European strategies on the subject. A particular result of this research is the definition ofa minimum set of indicators common to all cities, which can be applied for comparative purposes.
Understanding the Role of Nature in Urban-Rural Linkages: Identifying the Potential Role of Rural Nature-Based Attractive Clusters That Serve Human Well-Being
Authors: Cozzi Mario , Prete Carmelina , Viccaro Mauro , Sijtsma Frans , Veneri Paolo , Romano Severino
Published: September 2022

Rural areas provide unique amenities for recreational purposes which are highly appreciated by urban inhabitants. This generates an important but often hidden relationship between the urban and the rural. The aim of our study is first to provide empirical evidence for this linkage and then to identify for Italy, at the municipal level, those rural areas which actually function as nature-based attractive clusters. We used the data coming from a participatory webGIS survey that asked 1632 Italian respondents to mark attractive nature related places locally, regionally, nationally and world-wide to explain quantitatively and qualitatively the relationship between urban and rural. From the survey, indicators were developed to rank the nature-based attractive clusters. Our results pointed out a major (almost double) flow from urban to rural for natural amenities, which increased with the spatial level at which attractive nature areas were marked. This analysis allowed for the identification rural clusters of Italian municipalities that form nodal points for nature-based urban well-being; shedding light on an often neglected urban-rural relationship. The method is applicable in other countries and may stimulate better planning and management strategies for improving rural areas, taking an urban-rural perspective.
New Hermite–Hadamard Type Inequalities in Connection with Interval-Valued Generalized Harmonically (h1,h2)-Godunova–Levin Functions
Authors: Sahoo Soubhagya Kumar , Mohammed Pshtiwan Othman , O’Regan Donal O’ , Tariq Muhammad , Nonlaopon Kamsing
Published: September 2022

As is known, integral inequalities related to convexity have a close relationship with symmetry. In this paper, we introduce a new notion of interval-valued harmonically m,h1,h2-Godunova–Levin functions, and we establish some new Hermite–Hadamard inequalities. Moreover, we show how this new notion of interval-valued convexity has a close relationship with many existing definitions in the literature. As a result, our theory generalizes many published results. Several interesting examples are provided to illustrate our results.
Generalization of Two-Sided Length Biased Inverse Gaussian Distributions and Applications
Authors: Simmachan Teerawat , Phaphan Wikanda
Published: September 2022

The notion of length-biased distribution can be used to develop adequate models. Length-biased distribution was known as a special case of weighted distribution. In this work, a new class of length-biased distribution, namely the two-sided length-biased inverse Gaussian distribution (TS-LBIG), was introduced. The physical phenomenon of this scenario was described in a case of cracks developing from two sides. Since the probability density function of the original TS-LBIG distribution cannot be written in a closed-form expression, its generalization form was further introduced. Important properties such as the moment-generating function and survival function cannot be provided. We offered a different approach to solving this problem. Some distributional properties were investigated. The parameters were estimated by the method of the moment. Monte Carlo simulation studies were carried out to appraise the performance of the suggested estimators using bias, variance, and mean square error. An application of a real dataset was presented for illustration. The results showed that the suggested estimators performed better than the original study. The proposed distribution provided a more appropriate model than other candidate distributions for fitting based on Akaike information criterion.
CD163-Expressing Porcine Macrophages Support NADC30-like and NADC34-like PRRSV Infections
Authors: Xu Yulin , Ye Mengxue , Sun Shaohua , Cao Qi , Luo Jia , Wang Yuening , Zheng Wanglong , Meurens François , Chen Nanhua , Zhu Jianzhong
Published: September 2022

Porcine reproductive and respiratory syndrome virus (PRRSV) has a strict cell tropism. In addition to the primary alveolar macrophages, PRRSV is strictly cytotropic to African green monkey kidney cells, such as MARC-145 cells; however, MARC-145 cells are not infected by most NADC30-like and NADC34-like PRRSV strains. The essential scavenger receptor CD163 has been proved to mediate productive infection of PRRSV in various non-permissive cell lines. In this study, we systematically tested the porcine CD163 stably expressing 3D4/21 cells for infections with various PRRSV strains. The results showed that the porcine CD163-expressing macrophages support the infections of PRRSV2 of lineages 1, 5, and 8, as evidenced by Western blotting, immunofluorescence assay, quantitative PCR, and virus titration assay. Considering the current prevalence of NADC30-like and NADC34-like PRRSV2 of lineage 1 in China, the CD163-expressing macrophages are very useful for PRRSV research and disease management.
FDA-Approved Inhibitors of RTK/Raf Signaling Potently Impair Multiple Steps of In Vitro and Ex Vivo Influenza A Virus Infections
Authors: Meineke Robert , Stelz Sonja , Busch Maximilian , Werlein Christopher , Kühnel Mark , Jonigk Danny , Rimmelzwaan Guus F. , Elbahesh Husni
Published: September 2022

Influenza virus (IV) infections pose a burden on global public health with significant morbidity and mortality. The limited range of currently licensed IV antiviral drugs is susceptible to the rapid rise of resistant viruses. In contrast, FDA-approved kinase inhibitors can be repurposed as fast-tracked host-targeted antivirals with a higher barrier of resistance. Extending our recent studies, we screened 21 FDA-approved small-molecule kinase inhibitors (SMKIs) and identified seven candidates as potent inhibitors of pandemic and seasonal IV infections. These SMKIs were further validated in a biologically and clinically relevant ex vivo model of human precision-cut lung slices. We identified steps of the virus infection cycle affected by these inhibitors (entry, replication, egress) and found that most SMKIs affected both entry and egress. Based on defined and overlapping targets of these inhibitors, the candidate SMKIs target receptor tyrosine kinase (RTK)-mediated activation of Raf/MEK/ERK pathways to limit influenza A virus infection. Our data and the established safety profiles of these SMKIs support further clinical investigations and repurposing of these SMKIs as host-targeted influenza therapeutics.
Quantification of APOBEC3 Mutation Rates Affecting the VP1 Gene of BK Polyomavirus In Vivo
Authors: McIlroy Dorian , Peltier Cécile , Nguyen My-Linh , Manceau Louise , Mobuchon Lenha , Le Baut Nicolas , Nguyen Ngoc-Khanh , Tran Minh-Chau , Nguyen The-Cuong , Bressollette-Bodin Céline
Published: September 2022

Mutations in the BK polyomavirus (BKPyV) capsid accumulate in kidney transplant (KTx) recipients with persistent virus replication. They are associated with neutralization escape and appear to arise as a result of cytosine deamination by host cell APOBEC3A/B enzymes. To study the mutagenic processes occurring in patients, we amplified the typing region of the VP1 gene, sequenced the amplicons to a depth of 5000–10,000×, and identified rare mutations, which were fitted to COSMIC mutational signatures. Background mutations were identified in amplicons from plasmids carrying the BKPyV genome and compared to mutations observed in 148 samples from 23 KTx recipients in France and in Vietnam. Three mutational signatures were consistently observed in urine, serum, and kidney biopsy samples, two of which, SBS2 and SBS13, corresponded to APOBEC3A/B activity. In addition, a third signature with no known etiology, SBS89, was detected both in patient samples, and in cells infected in vitro with BKPyV. Quantitatively, APOBEC3A/B mutation rates in urine samples were strongly correlated with urine viral load, and also appeared to vary between individuals. These results confirm that APOBEC3A/B is a major, but not the only, source of BKPyV genome mutations in patients.
Reply to Alberts, P. Comment on “Hietanen et al. Cytolytic Properties and Genome Analysis of Rigvir® Oncolytic Virotherapy Virus and Other Echovirus 7 Isolates. Viruses 2022, 14, 525”
Authors: Hietanen Eero , Susi Petri
Published: September 2022

Our work focused on comparing the cellular effects of Rigvir to other echovirus 7 isolates, because originally Rigvir is also an echovirus 7 isolate [...]
Pathogenicity of Avian Polyomaviruses and Prospect of Vaccine Development
Authors: Wang Chen-Wei , Chen Yung-Liang , Mao Simon J. T. , Lin Tzu-Chieh , Wu Ching-Wen , Thongchan Duangsuda , Wang Chi-Young , Wu Hung-Yi
Published: September 2022

Polyomaviruses are nonenveloped icosahedral viruses with a double-stranded circular DNA containing approximately 5000 bp and 5–6 open reading frames. In contrast to mammalian polyomaviruses (MPVs), avian polyomaviruses (APVs) exhibit high lethality and multipathogenicity, causing severe infections in birds without oncogenicity. APVs are classified into 10 major species: Adélie penguin polyomavirus, budgerigar fledgling disease virus, butcherbird polyomavirus, canary polyomavirus, cormorant polyomavirus, crow polyomavirus, Erythrura gouldiae polyomavirus, finch polyomavirus, goose hemorrhagic polyomavirus, and Hungarian finch polyomavirus under the genus Gammapolyomavirus. This paper briefly reviews the genomic structure and pathogenicity of the 10 species of APV and some of their differences in terms of virulence from MPVs. Each gene’s genomic size, number of amino acid residues encoding each gene, and key biologic functions are discussed. The rationale for APV classification from the Polyomavirdae family and phylogenetic analyses among the 10 APVs are also discussed. The clinical symptoms in birds caused by APV infection are summarized. Finally, the strategies for developing an effective vaccine containing essential epitopes for preventing virus infection in birds are discussed. We hope that more effective and safe vaccines with diverse protection will be developed in the future to solve or alleviate the problems of viral infection.
Hijacking Host Immunity by the Human T-Cell Leukemia Virus Type-1: Implications for Therapeutic and Preventive Vaccines
Authors: Pise-Masison Cynthia A. , Franchini Genoveffa
Published: September 2022

Human T-cell Leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and other inflammatory diseases. High viral DNA burden (VL) in peripheral blood mononuclear cells is a documented risk factor for ATLL and HAM/TSP, and patients with HAM/TSP have a higher VL in cerebrospinal fluid than in peripheral blood. VL alone is not sufficient to differentiate symptomatic patients from healthy carriers, suggesting the importance of other factors, including host immune response. HTLV-1 infection is life-long; CD4+-infected cells are not eradicated by the immune response because HTLV-1 inhibits the function of dendritic cells, monocytes, Natural Killer cells, and adaptive cytotoxic CD8+ responses. Although the majority of infected CD4+ T-cells adopt a resting phenotype, antigen stimulation may result in bursts of viral expression. The antigen-dependent “on-off” viral expression creates “conditional latency” that when combined with ineffective host responses precludes virus eradication. Epidemiological and clinical data suggest that the continuous attempt of the host immunity to eliminate infected cells results in chronic immune activation that can be further exacerbated by co-morbidities, resulting in the development of severe disease. We review cell and animal model studies that uncovered mechanisms used by HTLV-1 to usurp and/or counteract host immunity.
COVID-19 Vaccines against Omicron Variant: Real-World Data on Effectiveness
Authors: Kherabi Yousra , Launay Odile , Luong Nguyen Liem Binh
Published: September 2022

The efficacy of vaccines against coronavirus disease 2019 (COVID-19) has now been well established in phase III clinical trials. However, clinical studies based on real-world data remain critical to assess vaccines effectiveness (VE), especially in specific populations and against variants of concern (VOC). This review presents the principles and methods of VE studies and the main available results on VE of COVID-19 vaccines at the time of Omicron circulation. References for this narrative review were identified through searches of PubMed database up to 13 September 2022. The results of phase III clinical trials have been globally confirmed by VE in real-life studies, including in the elderly. Emergence of VOC Omicron emphasized the importance of booster doses to maintain a high level of protection against severe forms. There are still numerous challenges regarding booster(s) and duration of immunity, particularly in specific subpopulations, and regarding the need for adapted vaccines.
Hemogram Findings in Cats from an Area Endemic for Leishmania infantum and Feline Immunodeficiency Virus Infections
Authors: Masucci Marisa , Donato Giulia , Persichetti Maria , Priolo Vito , Castelli Germano , Bruno Federica , Pennisi Maria
Published: September 2022

In feline Leishmania infantum (Li) infection and in clinical cases of feline leishmaniosis, co-infection with feline immunodeficiency virus (FIV) has been reported. However, the role of the retroviral co-infection in the impairment of feline clinical health is still controversial. The aim of this study was to evaluate hemogram changes in cats from regions endemic for both Li and FIV infection. Four hundred and ninety-six cats tested for Li (EDTA blood polymerase chain reaction and immunofluorescence antibody test) and for FIV infection (enzyme-linked immune assay) were retrospectively evaluated. Hemogram results including blood smear morphological evaluation were statistically compared considering four infection patterns: Li+FIV+, Li+FIV−, Li−FIV+, and Li−FIV−. Significantly lower values of erythrocytes (Li+FIV−: p = 0.0248; Li−FIV+: p = 0.0392) and hemoglobin (Li+FIV: p = 0.0086; Li−FIV+: p = 0.0249) were found in both infections when compared to Li−FIV− cats, and severity of anemia was more frequently moderate in Li-positive cats (p = 0.0206) and severe in FIV infection (p = 0.024). Li infection was associated with monocytosis (p = 0.0013) and morphologically activated monocytes (p = 0.0209). Moreover, FIV infection was associated with the presence of inflammatory leukogram (p = 0.023), and an association between thrombocytosis and the co-infection was found (p = 0.0347). Li infection in cats induces hematological changes compatible with chronic inflammation, some of which are due to co-infection with FIV.
Trichinella spiralis and T. britovi in North-Eastern Romania: A Six-Year Retrospective Multicentric Survey
Authors: Iacob Olimpia , Chiruță Ciprian , Mareș Mihai
Published: September 2022

The genus Trichinella includes species with a wide geographical spread that cause pathology in humans and animals. In this context, an epidemiological study of Trichinella infection was carried out in the northeastern part of Romania to investigate for the first time the prevalence of this infection in pigs, horses, wild boars and bears, the geographical distribution of Trichinella species and the natural reservoir of Trichinella infection. Between 2010 and 2015, a total of 166,270 animals were examined by the method of artificial digestion, in order to calculate the annual and general prevalence of Trichinella infection, according to the host and the Trichinella species involved, the Pearson correlation coefficient (r), trendline and geographical distribution of species of the genus Trichinella. Taxonomic framing was performed by the multiplex PCR method. The overall prevalence of Trichinella infection in animals was 0.188%. Within the host species, the prevalence varied as follows: in pigs 0.096%, horses 0.021%, wild boar 1.46% and bears 36.76%. The geographical distribution showed that T. spiralis was dominant, occupying the entire northeastern part of Romania, being identified in pigs, horses, wild boars and bears. T britovi occupied five mountain counties, being identified only in wild boars and bears. These results validate the presence of T. spiralis and T. britovi in domestic and game animals in the northeastern part of Romania.
Facilitating Development of Problem-Solving Skills in Veterinary Learners with Clinical Examples
Authors: Carr Amanda (Mandi) Nichole , Kirkwood Roy Neville , Petrovski Kiro Risto
Published: September 2022

This paper seeks to open discussion on the teaching of problem-solving skills in veterinary learners. We start by defining the term problem before discussing what constitutes problem-solving. For veterinary medical learners, problem-solving techniques are similar to those of decision-making and are integral to clinical reasoning. Problem-solving requires the veterinary learner to organize information logically to allow application of prior or new knowledge in arriving at a solution. The decision-making must encompass choices that provide the most beneficial and economical approach. In a modification of an existing protocol, we suggest the inclusion of the 5 elements: (1) define the problem list; (2) create an associated timeline; (3) describe the (anatomical) system involved or the pathophysiological principle applicable to the case; (4) propose management for the case; and (5) identify unique features of the case. During problem-solving activities, the instructor should take the role of facilitator rather than teacher. Skills utilized in the facilitation of problem-solving by learners include coaching, differential reinforcement, effective feedback, modelling and ‘think out loud’. Effective feedback must inform learners of their progress and performance, as this is fundamental to continued learning and motivation to succeed. In order to put the above into context, we end with an example case scenario showing how we would approach the teaching of problem-solving to veterinary learners.
Multiple Meningioma Resection by Bilateral Extended Rostrotentorial Craniotomy with a 3D-Print Guide in a Cat
Authors: Song Kyohyuk , Lee Haebeom , Jeong Jaemin , Roh Yoonho
Published: September 2022

A 13-year-old castrated male domestic shorthair cat was referred for the surgical removal of multiple meningiomas. The cat experienced generalized tonic–clonic seizures, altered mentation, mild proprioceptive ataxia, and circling. Magnetic resonance imaging (MRI) revealed two round, solitary, well-delineated, space-occupying lesions suggestive of multiple meningiomas in the right frontal and occipital lobes. Before surgery, patient-specific three-dimensional (3D) printed models and guides were produced using a 3D program based on MRI and computed tomography (CT), and a rehearsal surgery was performed. With a 3D guide to find the location of the craniotomy lines, bilateral extended rostrotentorial craniotomy allowed en bloc resection of multiple meningiomas. The bone fragment was replaced and secured to the skull with a craniofacial plate and screws with an artificial dura. All of the surgical steps were performed without complications. The preoperative presenting signs were resolved by the time of follow-up examinations 2 weeks after surgery. Twelve months after the removal of the multiple meningiomas, the cat survived without further neurological progression. For the resection of multiple meningiomas, surgery can result in large bone defects and risk of massive hemorrhage. For this challenging surgery, patient-specific 3D models and guides can be effective for accurate and safe craniotomies.
Large-Scale Extraction and Mapping of Small Surface Water Bodies Based on Very High-Spatial-Resolution Satellite Images: A Case Study in Beijing, China
Authors: Ji Zhonglin , Zhu Yu , Pan Yaozhong , Zhu Xiufang , Zheng Xuechang
Published: September 2022

Surface water is a crucial resource and environmental element for human survival and ecosystem stability; therefore, accurate information on the distribution of surface water bodies is essential. Extracting this information on a large scale is commonly implemented using moderate- and low-resolution satellite images. However, the detection and analysis of more detailed surface water structures and small water bodies necessitate the use of very high-resolution (VHR) satellite images. The large-scale application of VHR images for water extraction requires convenient and accurate methods. In this paper, a method combining a pixel-level water index and image object detection is proposed. The method was tested using 2018/2019 multispectral 4-m resolution images obtained from the Chinese satellite Gaofen-2 across Beijing, China. Results show that the automatic extraction of water body information over large areas using the proposed method and VHR images is feasible. Kappa coefficient and overall accuracy of 0.96 and 99.8% after post-classification improvement were obtained for testing images inside the Beijing area. The Beijing water body dataset obtained included a total of 489.53 km2 of surface water in 2018/2019, 108.01 km2 of which were ponds with an area smaller than 2 km2. This study can be applied for water body extraction and mapping in other large regions and provides a reference for other methods for using VHR images to extract water body information on a large scale.
Catalytic Partial Desalination of Saline Water
Authors: Antia David D. J.
Published: September 2022

More than 1 billion ha of land is adversely affected by salinization, including about 54 million ha of irrigated cropland. This study trials a batch flow, bubble column, static bed, catalytic, pressure swing adsorption−desorption, zero valent iron, and diffusion reactor train, which is designed to partially desalinate water, for use as either livestock feed water or partially desalinated irrigation water. ZVI desalination produces a partially desalinated water product, without producing a waste brine product. The trial demonstrates sequential batch processing of 50 (0.86 m3) batches of saline water (43 m3 total), using a single ZVI charge, without loss of activity. The trialed feed water contained between 1 and 9 g NaCl L−1. The average desalination was 41.84% (standard deviation was 15.61%). The optimum batch processing time is determined as being between 12 and 24 h. For each batch, the first-order forward rate constants, for both Cl− and Na+ ion removal, decline with time. The study considers the irrigation application of the product water on crop yield for 70 crop varieties; the application of the technology to desalinate a saline aquifer; applications of the technology to improve the environmental efficiency of conventional desalination plants.
Securing Flows in the River Systems through Irrigation Water Use Efficiency—A Case Study from Karula River in the Ganga River System
Authors: Kaushal Nitin , Babu Suresh , Mishra Arjit , Bajpai Rajesh , Sinha Phanish Kumar , Arya Rama Kant , Tickner David , Linstead Conor
Published: September 2022

The pressure on freshwater resources is leading to diminishing flows in some of the critical river systems across the globe. India is no exception, and this is mainly because of water withdrawal for irrigation, which is often to the tune of 70% to 80% of the lean season flows, with some proportion for domestic and industrial use. While graduating from the concept of environmental flows and its assessment methodologies in India, the water-managers, the researchers and the conservationists are now moving towards answering the next question, if the rivers are to be revived, where will the water come from, especially in the case of over-allocated rivers, including the River Ganga. While the logical way is to look at the biggest user of water, i.e., irrigation, it remains to be seen whether the irrigation water savings will actually lead to enhancing flows in a river, complementing the efforts towards maintaining e-flows in rivers, or whether it will lead to more area under agriculture, bring changes in cropping patterns towards more water-intensive crops or result in something else. This is a growing debate across the globe, where India is no exception, and there has been a wide range of opinions in this regard. This paper discusses the process, findings and lessons from a joint initiative involving farmers, the Uttar Pradesh state Irrigation and Water Resources Department, Bijnor District Administration and a conservation organisation, WWF, to enhance flows in a sub-tributary, called the Karula River, which is part of the Ganga River system. Another objective of this paper is to look at the scalability and replicability of similar approaches in other irrigation command areas to benefit nearby river systems in general. Under this initiative, the team attempted to enhance flows in the river Karula by routing the saved water from irrigation supplies in a canal commanded area. This saving of water is being achieved due to supply-side and demand-side measures that are being adopted in the project area. With the objective of ensuring the sustainability of the initiative, efforts are made to form an institutional arrangement, through which this initiative can be sustained beyond the project support.
Contamination Assessment and Source Analysis of Urban Waterways Based on Bayesian and Principal Component Analysis—A Case Study of Fenjiang River
Authors: Pang Jiafeng , Lin Kairong , Gan Wenhui , Hu Sike , Luo Wei
Published: September 2022

Contamination assessment and source analysis of urban waterways are important for the environmental management of water resources. This study applied an improved water quality index (WQI), which was called WQI-DET (water quality index deterioration) to analyze the Fenjiang River’s (Foshan City, South China) water quality monitoring data from 2016 to 2021. Between 2016 and 2021, the Fenjiang River had the highest WQI-DET value in 2016. Since then, the water quality has shown a decreasing trend year by year. Then, through Spearman analysis, it was identified that the chemical oxygen demand (COD) and ammonia nitrogen (NH3-N) are the main factors of water quality deterioration. Moreover a Bayesian model was used to analyze and evaluate the main factors. On this basis, relationships between COD, NH3-N, the natural environment, and human activities were analyzed by principal component analysis. The results showed that NH3-N has been the main factor affecting the water quality in recent years and there were no significant changes in COD and NH3-N during the study period. However, COD and NH3-N showed significant differences in spatial distribution. Meanwhile, human activities contributed 52.3% to the variability in the water quality of the Fenjiang River, and natural factors only 26.8%; factors not considered in this study contributed the remaining 20.9%. Human activities had a more significant impact on the water quality of the Fenjiang River than natural factors.
The Role of the Andalusian Institute for Agrarian Reform (IARA) in Irrigation Expansion: The Case of the Chanza Irrigation Project (Huelva, Spain)
Authors: Jurado Almonte José Manuel , Díaz Diego José
Published: September 2022

In the last two decades of the 20th century, irrigation in Andalusia experienced a historic expansion as a result of the transfer of political powers from the State to regional authorities and, thanks to its application in Andalusia, to pass, among other measures, an agrarian reform bill and the subsequent development of new irrigation infrastructures. Against this background, our objective was to determine the role of the body responsible for implementing agrarian reform, i.e., the Institute for Agrarian Reform (Instituto Andaluz de Reforma Agraria, IARA), by converting drylands into irrigation lands, with a special focus on one of the region’s most vibrant agro-economically transformed areas: the irrigable area of the River Chanza (the west coast of the province of Huelva). To conduct the study, we have applied the historical method and content analysis to technical, legal and agro-statistical documentation from the entire active period of the IARA (1984–2011). The results highlight the leading role played by the IARA in extending irrigation land in agrarian-reform priority areas, as well as in developing irrigation infrastructures in the areas that the State defined as strategic in Andalusia, such as the 17,200 hectares of irrigated land of the Chanza Irrigation Project. We conclude that the radical agro-productive transformation of the coast of Huelva in recent decades is mainly due to the availability of water for irrigation, which the IARA was primarily responsible for planning and executing.
Uncertainty Analysis of Numerical Simulation of Seawater Intrusion Using Deep Learning-Based Surrogate Model
Authors: Miao Tiansheng , Huang He , Guo Jiayuan , Li Guanghua , Zhang Yu , Chen Naijia
Published: September 2022

Seawater intrusion is expected to cause a shortage of freshwater resources in coastal areas which will hinder regional economic and social development. The consequences of global climate change include rising sea levels, which also affect the results of the predictions of seawater intrusion that are based on simulations. It is thus important to examine the impact of the randomness in the rise in sea levels on the uncertainty in the results of numerical simulations that are used to predict seawater intrusion. Deep learning has lately emerged as a popular area of research that has been used to establish surrogate models in this context. In this study, the authors have used deep learning to determine the complex and nonlinear mapping relationship between the inputs and outputs of a three-dimensional variable-density numerical model of seawater intrusion in the case of a limited number of training samples, wherein, this has improved the accuracy of the approximation of the surrogate models. We used the rise in sea level as a random variable, and then applied the Monte Carlo method to analyze the influence of randomness on the uncertainty in the results of the numerical predictions of seawater intrusion. Statistical analyses and interval estimations of the Cl− concentration and the area of seawater intrusion were conducted at typical observation wells. The work that is here provides a reliable reference for decision making in the area.