bluuebunny/crossref_metadata_2025 huggingface dataset:
Different response of the oxygen pathway in patients with chronic thromboembolic pulmonary hypertension treated with pulmonary endarterectomy versus balloon pulmonary angioplasty
Authors: Fu Zhihui , Tao Xincao , Xie Wanmu , Yang Peiran , Gao Qian , Wang Jinzhi , Zhai Zhenguo
Published: September 2022

Background

Oxygen pathway limitation exists in chronic thromboembolic pulmonary hypertension (CTEPH). Pulmonary endarterectomy (PEA) and balloon pulmonary angioplasty (BPA) are two effective interventions for CTEPH, but their effects and comparison of these two interventions on the oxygen pathway are not well demonstrated.

Methods

CTEPH patients with available pulmonary function test, hemodynamics, and blood gas analysis before and after the interventions were included for comparison of oxygen pathway in terms of lung ventilation, lung gas exchange, oxygen delivery, and oxygen extraction between these two interventions.

Results

The change in the percentage of the predicted forced expiratory volume in the 1 s (−3.4 ± 12.7 vs. 3.8 ± 8.7%, P = 0.006) and forced vital capacity (−5.5 ± 13.0 vs. 4.2 ± 9.9%, P = 0.001) among the PEA group (n = 24) and BPA group (n = 46) were significantly different. Patients in the PEA group had a significant increase in their arterial oxygen saturation (from 92.5 ± 3.6 to 94.6 ± 2.4%, P = 0.022), while those in the BPA group had no change, which could be explained by a significant improvement in ventilation/perfusion (−0.48 ± 0.53 vs. −0.17 ± 0.41, P = 0.016). Compared with patients post-BPA, patients post-PEA were characterized by higher oxygen delivery (756.3 ± 229.1 vs. 628.8 ± 188.5 ml/min, P = 0.016) and higher oxygen extraction (203.3 ± 64.8 vs. 151.2 ± 31.9 ml/min, P = 0.001).

Conclusion

Partial amelioration of the oxygen pathway limitations could be achieved in CTEPH patients treated with PEA and BPA. CTEPH patients post-PEA had better performance in lung gas exchange, oxygen delivery, and extraction, while those post-BPA had better lung ventilation. Cardiopulmonary rehabilitation may assist in improving the impairment of the oxygen pathway.
Associations of muscle size and fatty infiltration with bone mineral density of the proximal femur bone
Authors: Li Junfei , Wang Yijing , Zhang Xuesong , Zhang Ping , Su Yunshan , Bai Lin , Wang Yali , Wang Ming , Zhao Jian
Published: September 2022

Purpose

To investigate the relationship of muscle atrophy and fat infiltration around the hip joint with areal bone mineral density (aBMD) in each subregion of the proximal femur.

Materials and methods

In total, 144 participants (66 women and 78 men) were examined by quantitative computed tomography (QCT), and areal bone mineral density (aBMD) of the femoral neck (FN), trochanter (TR), and intertrochanter (IT) of the proximal femur were obtained. The cross-sectional area (CSA) and proton density fat fraction (PDFF) of the gluteus maximus (G.MaxM), gluteus medius (G.MedM), gluteus minimus (G.MinM), and iliopsoas (IliopM) were obtained via magnetic resonance imaging (MRI) using the mDIXON-Quant sequence. A multivariate generalized linear model was used to evaluate the correlation of the CSA and PDFF of muscles with aBMD in all subregions of the proximal femur.

Results

The FN integral (Int) aBMD was significantly associated with the G.MaxM CSA (men: P = 0.002; women: P = 0.008) and PDFF (men: P < 0.001; women: P = 0.047). Some muscle indexes were related to the FN aBMD in males or females, including the CSA of G.MedM, G.MinM, and IliopM as well as the PDFF of IliopM and G.MinM. Associations of hip muscle parameters with the TR Int aBMD in both males and females were observed, including G.MaxM CSA (men: P < 0.001; women: P = 0.028) and G.MaxM PDFF (men: P = 0.031; women: P = 0.038). Other muscle indexes, including G.MedM and IliopM, were related to the TR aBMD, mainly affecting the aBMD of TR cortical (Cort) and TR Int. The IT Int aBMD and IT Cort aBMD showed significant correlation with the muscle indexes of G. MaxM, IliopM, and G.MedM, including the PDFF and CSA in males and females. Further, more indicators of the G.MedM and IliopM correlated with the TR and IT aBMD compared to the FN aBMD.

Conclusions

The CSA of gluteus muscles and iliopsoas had a positive association with the aBMD in the proximal femur, and the PDFF of gluteus muscles and iliopsoas had a negative correlation with the aBMD in the proximal femur. In addition, there was an interaction of the proximal femur aBMD with the muscle size and fatty infiltration of hip muscles.
Identifying shared priorities for a bioregional approach to restoration in the Northern Gulf of Mexico
Authors: Guilbeau Kelly G. , Hijuelos Ann C. , Romañach Stephanie S. , Steyer Gregory D.
Published: September 2022

Natural resource management is often challenged with a mismatch between the scale of decision-making and the scale of the biological, ecological, and physical processes that control a system. Bioregional approaches to adaptive management have emerged as an approach to inform natural resource management at ecologically relevant scales and across multi-level governance structures. The implementation of adaptive management requires the determination of ecological and social priorities that can inform a desired system state across multiple governing bodies. We use the Northern Gulf of Mexico, United States, as a case study for a bioregional approach to adaptive management and illustrate a method for developing objectives and management priorities across programs and jurisdictions. Through this synthesis, using qualitative coding methods to develop a shared vocabulary across the diverse dataset, we identified commonalities and differences in ecological and human community priorities across the five states which line the Northern Gulf of Mexico. Using these shared priorities, we conceptualize a network of priority-focused objectives as a starting point for further stakeholder engagement and effectively monitoring and evaluating progress across boundaries. This approach serves as a framework for cross-program adaptive management by illustrating a desired system state that reflects the shared priorities among decision-making authorities in this region and offering individual programs or projects a method to articulate their contributions to the broader set of shared priorities Gulf-wide. This method can be used by restoration managers in any region of the world to align project objectives within cross-jurisdictional boundaries and illustrate the value of a bioregional approach to restoration.
Machine learning reveals two heterogeneous subtypes to assist immune therapy based on lipid metabolism in lung adenocarcinoma
Authors: Gu Xuyu , Wei Shiyou , Li Zhixin , Xu Huan
Published: September 2022

Background

Lipid metabolism pivotally contributes to the incidence and development of lung adenocarcinoma (LUAD). The interaction of lipid metabolism and tumor microenvironment (TME) has become a new research direction.

Methods

Using the 1107 LUAD records from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, a comprehensive exploration was performed on the heterogeneous lipid metabolism subtypes based on lipid metabolism genes (LMGs) and immune-related genes (LRGs). The clinical significance, functional status, TME interaction and genomic changes of different subtypes were further studied. A new scoring system, lipid-immune score (LIS), was developed and validated.

Results

Two heterogeneous subtypes, which express more LMGs and show the characteristics of tumor metabolism and proliferation, are defined as lipid metabolism phenotypes. The prognosis of lipid metabolism phenotype is poor, and it is more common in patients with tumor progression. Expressing more IRGs, enrichment of immunoactive pathways and infiltration of effector immune cells are defined as immunoactive phenotypes. The immunoactive phenotype has a better prognosis and stronger anti-tumor immunity and is more sensitive to immunotherapy. In addition, KEAP1 is a driving mutant gene in the lipid metabolism subtype. Finally, LIS was developed and confirmed to be a robust predictor of overall survival (OS) and immunotherapy in LUAD patients.

Conclusion

Two heterogeneous subtypes of LUAD (lipid metabolism subtype and immune activity subtype) were identified to evaluate prognosis and immunotherapy sensitivity. Our research promotes the understanding of the interaction between lipid metabolism and TME and offers a novel direction for clinical management and precision therapy aimed to LUAD patients.
Identification of stage-associated exosome miRNAs in colorectal cancer by improved robust and corroborative approach embedded miRNA-target network
Authors: Long Fei , Tian Luyao , Chai Zixuan , Li Jing , Tang Ying , Liu Mingwei
Published: September 2022

Background

Colorectal cancer (CRC) is a common gastrointestinal tumor with high morbidity and mortality. At the molecular level, patients at different stages present considerable heterogeneity. Although the miRNA in exosome is an effective biomarker to reveal tumor progression, studies based on stage-associated exosome miRNA regulatory network analysis still lacking. This study aims to identify CRC stage-associated exosome miRNAs and reveal their potential function in tumor progression.

Methods

In this study, serum and cellular exosome miRNA expression microarrays associated with CRC were downloaded from GEO database. Stage-common (SC) and stage-specific (SS) differentially expressed miRNAs were extracted and their targets were identified based on 11 databases. Furthermore, miRNA SC and SS regulatory function networks were built based on the CRC phenotypic relevance of miRNA targets, and the corresponding transcription factors were identified. Concurrently, the potential stage-associated miRNAs were identified by receiver-operating characteristic (ROC) curve analysis, survival analysis, drug response analysis, ceRNA analysis, pathway analysis and a comprehensive investigation of 159 publications.

Results

Ten candidate stage-associated miRNAs were identified, with three SC (miR-146a-5p, miR-22-3p, miR-23b-3p) and seven SS (I: miR-301a-3p, miR-548i; IIIA: miR-23a-3p; IV: miR-194-3p, miR-33a-3p, miR-485-3p, miR-194-5p) miRNAs. Additionally, their targets were enriched in several vital cancer-associated pathways such as TGF-beta, p53, and hippo signaling pathways. Moreover, five key hotspot target genes (CCNA2, MAPK1, PTPRD, MET, and CDKN1A) were demonstrated to associated with better overall survival in CRC patients. Finally, miR-23b-3p, miR-301a-3p and miR-194-3p were validated being the most stably expressed stage-associated miRNAs in CRC serum exosomes, cell exosomes and tissues.

Conclusions

These CRC stage-associated exosome miRNAs aid to further mechanism research of tumor progression and provide support for better clinical management in patients with different stages.
Triglyceride affects the association between estimated glomerular filtration rate and the onset of non-alcoholic fatty liver disease: A second analysis of a Chinese cohort study
Authors: Hu Haofei , Cao Changchun , Han Yong , He Yongcheng
Published: September 2022

Objective

The role of triglyceride (TG) and estimated glomerular filtration rate (eGFR) effect modifiers on the risk of non-alcoholic fatty liver disease (NAFLD) is unknown. This study examined whether TG modifies the relationship between eGFR and incident NAFLD.

Methods

In a Chinese hospital from January 2010 to December 2014, 15,555 non-obese subjects were collected systematically for this retrospective cohort study. The target-independent and dependent variables were eGFR measured at baseline and NAFLD appearing during follow-up. The modified variable was TG measured at baseline. The multivariate Cox proportional hazards model was used to explore eGFR and TG’s association with NAFLD risk. We explored a priori interaction between eGFR and TG, and performed subgroup analyses to further assess whether the relationship between eGFR and incident NAFLD was modified by TG. We also explored the effect of TG and eGFR interaction on the risk of NAFLD.

Results

The mean age was 43.09 ± 14.92 years, and 8,131 (52.27%) were males. During a median follow-up time of 35.8 months, 2,077 (13.35%) individuals developed NAFLD. In the adjusted model, eGFR was negatively associated with incident NAFLD (HR = 0.984, 95% CI: 0.982, 0.987), while TG was positively related to NAFLD (HR = 1.582, 95% CI: 1.490, 1.681). TG could modify the relationship between eGFR and incident NAFLD. A stronger association between eGFR and NAFLD could be found in the participants without hypertriglyceridemia (HTG) (HR = 0.981, 95% CI: 0.978–0.984, P for interaction = 0.0139). In contrast, the weaker association was probed in the population with HTG (HR = 0.986, 95% CI: 0.983–0.989). At the same time, we also found an interaction between eGFR and TG in influencing NAFLD risk. In participants with decreased eGFR and HTG, the risk of NAFLD was significantly increased. Further, compared to non-HTG subjects with eGFR ≥ 116.56 ml/min/1.73 m2, participants with HTG and eGFR < 82.88 ml/min/1.73 m2 had about a fourfold increase in the risk (HR = 4.852 95% CI: 3.943–5.970) of NAFLD.

Conclusion

eGFR and TG is independently associated with NAFLD risk. The association of eGFR with incident NAFLD is likely to be modified by TG in the Chinese non-obese population. There was an interactive effect between eGFR and TG in affecting NAFLD risk. In participants with decreased eGFR and hypertriglyceridemia, the risk of NAFLD is significantly increased.
General anesthesia in children and long-term neurodevelopmental deficits: A systematic review
Authors: Xiao Aoyi , Feng Yingying , Yu Shan , Xu Chunli , Chen Jianghai , Wang Tingting , Xiao Weimin
Published: September 2022

Background

Millions of children experienced surgery procedures requiring general anesthesia (GA). Any potential neurodevelopmental risks of pediatric anesthesia can be a serious public health issue. Various animal studies have provided evidence that commonly used GA induced a variety of morphofunctional alterations in the developing brain of juvenile animals.

Methods

We conducted a systematic review to provide a brief overview of preclinical studies and summarize the existing clinical studies. Comprehensive literature searches of PubMed, EMBASE, CINAHL, OVID Medline, Web of Science, and the Cochrane Library were conducted using the relevant search terms “general anesthesia,” “neurocognitive outcome,” and “children.” We included studies investigating children who were exposed to single or multiple GA before 18, with long-term neurodevelopment outcomes evaluated after the exposure(s).

Results

Seventy-two clinical studies originating from 18 different countries published from 2000 to 2022 are included in this review, most of which are retrospective studies (n = 58). Two-thirds of studies (n = 48) provide evidence of negative neurocognitive effects after GA exposure in children. Neurodevelopmental outcomes are categorized into six domains: academics/achievement, cognition, development/behavior, diagnosis, brain studies, and others. Most studies focusing on children <7 years detected adverse neurocognitive effects following GA exposure, but not all studies consistently supported the prevailing view that younger children were at greater risk than senior ones. More times and longer duration of exposures to GA, and major surgeries may indicate a higher risk of negative outcomes.

Conclusion

Based on current studies, it is necessary to endeavor to limit the duration and numbers of anesthesia and the dose of anesthetic agents. For future studies, we require cohort studies with rich sources of data and appropriate outcome measures, and carefully designed and adequately powered clinical trials testing plausible interventions in relevant patient populations.
Distal extrahepatic cholangiocarcinoma mimicking groove pancreatitis: A case report and literature review
Authors: Han Chaoqun , Ling Xin , Sheng Liping , Yang Ming , Lin Rong , Ding Zhen
Published: September 2022

Background

The differential diagnosis between cholangiocarcinoma and groove pancreatitis is quite challenging. Groove pancreatitis is commonly misdiagnosed as periampullary tumors. We reported a case of distal extrahepatic cholangiocarcinoma mimicking groove pancreatitis.

Case report

A 57-year-old male patient was transferred to our hospital after endoscopic retrograde cholangiopancreatography (ERCP) with stent placement in the common bile duct due to obstructive jaundice at a local hospital. Groove pancreatitis was considered based on the clinical manifestations and multiple examinations [including computed tomography (CT), magnetic resonance cholangiopancreatography (MRCP), and endoscopic ultrasonography (EUS)]. The patient’s symptoms and laboratory results almost returned to normal after conservative treatments. Interestingly, his symptoms and laboratory results worsened after the stent was removed. We performed a second EUS process and found a lesion in the lower common bile duct. Finally, the patient underwent pancreatoduodenectomy, and the diagnosis was confirmed as moderately differentiated adenocarcinoma of the common bile duct.

Conclusion

Our case highlights the fact that distal extrahepatic cholangiocarcinoma, which is a malignant disease, can mimic a benign condition like groove pancreatitis. Our case also raises the concern that performing stent placement through ERCP to relieve jaundice without a clear diagnosis could interfere with further evaluation of the disease.
Development and validation of a prognostic nomogram for predicting cancer-specific survival in patients with metastatic clear cell renal carcinoma: A study based on SEER database
Authors: Huang Guangyi , Liao Jie , Cai Songwang , Chen Zheng , Qin Xiaoping , Ba Longhong , Rao Jingmin , Zhong Weimin , Lin Ying , Liang Yuying , Wei Liwei , Li Jinhua , Deng Kaifeng , Li Xiangyue , Guo Zexiong , Wang Liang , Zhuo Yumin
Published: September 2022

Objectives

Clear cell renal cell carcinoma (ccRCC) is highly prevalent, prone to metastasis, and has a poor prognosis after metastasis. Therefore, this study aimed to develop a prognostic model to predict the individualized prognosis of patients with metastatic clear cell renal cell carcinoma (mccRCC).

Patients and Methods

Data of 1790 patients with mccRCC, registered from 2010 to 2015, were extracted from the Surveillance, Epidemiology and End Results (SEER) database. The included patients were randomly divided into a training set (n = 1253) and a validation set (n = 537) based on the ratio of 7:3. The univariate and multivariate Cox regression analyses were used to identify the important independent prognostic factors. A nomogram was then constructed to predict cancer specific survival (CSS). The performance of the nomogram was internally validated by using the concordance index (C-index), calibration plots, receiver operating characteristic curves, net reclassification improvement (NRI), integrated discrimination improvement (IDI), and decision curve analysis (DCA). We compared the nomogram with the TNM staging system. Kaplan–Meier survival analysis was applied to validate the application of the risk stratification system.

Results

Diagnostic age, T-stage, N-stage, bone metastases, brain metastases, liver metastases, lung metastases, chemotherapy, radiotherapy, surgery, and histological grade were identified as independent predictors of CSS. The C-index of training and validation sets are 0.707 and 0.650 respectively. In the training set, the AUC of CSS predicted by nomogram in patients with mccRCC at 1-, 3- and 5-years were 0.770, 0.758, and 0.757, respectively. And that in the validation set were 0.717, 0.700, and 0.700 respectively. Calibration plots also showed great prediction accuracy. Compared with the TNM staging system, NRI and IDI results showed that the predictive ability of the nomogram was greatly improved, and DCA showed that patients obtained clinical benefits. The risk stratification system can significantly distinguish the patients with different survival risks.

Conclusion

In this study, we developed and validated a nomogram to predict the CSS rate in patients with mccRCC. It showed consistent reliability and clinical applicability. Nomogram may assist clinicians in evaluating the risk factors of patients and formulating an optimal individualized treatment strategy.
Effect of lymph node resection on prognosis of resectable intrahepatic cholangiocarcinoma: A systematic review and meta-analysis
Authors: Li Feiyu , Jiang Yong , Jiang Liyong , Li Qingbin , Yan Xiangyu , Huang Songhan , Chen Ji , Yuan Shuai , Fu Yingda , Liu Jun
Published: September 2022

Background

The purpose of this meta-analysis was to evaluate the efficacy of lymph node dissection in patients with intrahepatic cholangiocarcinoma (ICC).

Methods

The literature from January 2009 to December 2021 was searched to determine the comparative study of lymph node dissection and non-lymph node dissection in patients with ICC.

Results

Seventeen studies were included in the analysis. There were no significant differences in 1-, 3-, and 5-year overall survival (OR = 0.80, p = 0.10; OR = 0.93, p = 0.71; OR = 0.80, p = 0.21) and 1-, 3-, and 5-year disease-free survival (OR = 0.89, p = 0.73; OR = 0.92, p = 0.81; OR = 0.85, p = 0.62).

Conclusions

Lymph node dissection does not seem to have a positive effect on the overall survival and disease-free survival.
Targeted therapy in NPM1-mutated AML: Knowns and unknowns
Authors: Wang Rong , Xu Pan , Chang Lin-Lin , Zhang Shi-Zhong , Zhu Hong-Hu
Published: September 2022

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by malignant proliferation of myeloid hematopoietic stem/progenitor cells. NPM1 represents the most frequently mutated gene in AML and approximately 30% of AML cases carry NPM1 mutations. Mutated NPM1 result in the cytoplasmic localization of NPM1 (NPM1c). NPM1c interacts with other proteins to block myeloid differentiation, promote cell proliferation and impair DNA damage repair. NPM1 is a good prognostic marker, but some patients ultimately relapse or fail to respond to therapy. It is urgent for us to find optimal therapies for NPM1-mutated AML. Efficacy of multiple drugs is under investigation in NPM1-mutated AML, and several clinical trials have been registered. In this review, we summarize the present knowledge of therapy and focus on the possible therapeutic interventions for NPM1-mutated AML.
Application of FT-IR spectroscopy and chemometric technique for the identification of three different parts of Camellia nitidissima and discrimination of its authenticated product
Authors: Tew Wan Yin , Ying Chen , Wujun Zhang , Baocai Liu , Yoon Tiem Leong , Yam Mun Fei , Jingying Chen
Published: September 2022

Camellia nitidissima C.W. Chi is a golden camellia recognized in Chinese herbology and widely used as tea and essential oil in Chinese communities. Due to its diverse pharmacological properties, it can be used to treat various diseases. However, unethical sellers adulterated the flower with other parts of Camellia nitidissima in their product. This study used an integrated tri-step infrared spectroscopy method and a chemometric approach to distinguish C. nitidissima’s flowers, leaves, and seeds. The three different parts of C. nitidissima were well distinguished using Fourier transform infrared spectroscopy (FT-IR), second-derivative infrared (SD-IR) spectra, and two-dimensional correlation infrared (2D-IR) spectra. The FT-IR and SD-IR spectra of the samples were subjected to principal component analysis (PCA), PCA-class, and orthogonal partial least square discriminant analysis (OPLS-DA) for classification and discrimination studies. The three parts of C. nitidissima were well separated and discriminated by PCA and OPLS-DA. The PCA-class model’s sensitivity, accuracy, and specificity were all >94%, indicating that PCA-class is the good model. In addition, the RMSEE, RMSEP, and RMSECV values for the OPLS-DA model were low, and the model’s sensitivity, accuracy, and specificity were all 100%, showing that it is the excellent one. In addition, PCA-class and OPLS-DA obtained scores of 27/32 and 26/32, respectively, for detecting adulterated and other TCM reference flower samples from C. nitidissima. Combining an infrared spectroscopic method with a chemometric approach proved that it is possible to differentiate distinct sections of C. nitidissima and discriminate adulterated samples of C.nitidissima flower.
Implications of notch signaling in duchenne muscular dystrophy
Authors: Den Hartog Lily , Asakura Atsushi
Published: September 2022

This review focuses upon the implications of the Notch signaling pathway in muscular dystrophies, particularly Duchenne muscular dystrophy (DMD): a pervasive and catastrophic condition concerned with skeletal muscle degeneration. Prior work has defined the pathogenesis of DMD, and several therapeutic approaches have been undertaken in order to regenerate skeletal muscle tissue and ameliorate the phenotype. There is presently no cure for DMD, but a promising avenue for novel therapies is inducing muscle regeneration via satellite cells (muscle stem cells). One specific target using this approach is the Notch signaling pathway. The canonical Notch signaling pathway has been well-characterized and it ultimately governs cell fate decision, cell proliferation, and induction of differentiation. Additionally, inhibition of the Notch signaling pathway has been directly implicated in the deficits seen with muscular dystrophies. Here, we explore the connection between the Notch signaling pathway and DMD, as well as how Notch signaling may be targeted to improve the muscle degeneration seen in muscular dystrophies.
Salt stress resilience in plants mediated through osmolyte accumulation and its crosstalk mechanism with phytohormones
Authors: Singh Pooja , Choudhary Krishna Kumar , Chaudhary Nivedita , Gupta Shweta , Sahu Mamatamayee , Tejaswini Boddu , Sarkar Subrata
Published: September 2022

Salinity stress is one of the significant abiotic stresses that influence critical metabolic processes in the plant. Salinity stress limits plant growth and development by adversely affecting various physiological and biochemical processes. Enhanced generation of reactive oxygen species (ROS) induced via salinity stress subsequently alters macromolecules such as lipids, proteins, and nucleic acids, and thus constrains crop productivity. Due to which, a decreasing trend in cultivable land and a rising world population raises a question of global food security. In response to salt stress signals, plants adapt defensive mechanisms by orchestrating the synthesis, signaling, and regulation of various osmolytes and phytohormones. Under salinity stress, osmolytes have been investigated to stabilize the osmotic differences between the surrounding of cells and cytosol. They also help in the regulation of protein folding to facilitate protein functioning and stress signaling. Phytohormones play critical roles in eliciting a salinity stress adaptation response in plants. These responses enable the plants to acclimatize to adverse soil conditions. Phytohormones and osmolytes are helpful in minimizing salinity stress-related detrimental effects on plants. These phytohormones modulate the level of osmolytes through alteration in the gene expression pattern of key biosynthetic enzymes and antioxidative enzymes along with their role as signaling molecules. Thus, it becomes vital to understand the roles of these phytohormones on osmolyte accumulation and regulation to conclude the adaptive roles played by plants to avoid salinity stress.
Personality of nonprofit organizations’ Instagram accounts and its relationship with their photos’ characteristics at content and pixel levels
Authors: Kim Yunhwan
Published: September 2022

Nonprofit organizations (NPO) can utilize social networking sites (SNSs) for their activities. Like individual users, they can create SNS accounts, upload posts to show what they are doing, and communicate with other users. Thus, their accounts can be investigated from the same perspective of personality which has been one of the key lenses through which SNS posts of individual users was investigated. In the line of literature that analyzed the personality of non-human objects such as products, stores, brands, and websites, the present research analyzed the personality of NPOs’ Instagram accounts using an online AI service. Also, it investigated how their personality traits were related to the characteristics of the uploaded photos at content and pixel levels. The results of analysis of 223,446 photos on 177 Instagram accounts suggested that the personality of NPOs’ Instagram accounts can be summarized as being high in openness and agreeableness but low in extraversion and neuroticism. And it was found that openness and agreeableness were the personality traits that associated the most with the photo features. Also, the personality traits of NPOs’ Instagram accounts, except neuroticism, were predicted from the photo features with an acceptable level of accuracy. Implications of this research and suggestions for further research were presented.
The application of network agenda setting model during the COVID-19 pandemic based on latent dirichlet allocation topic modeling
Authors: Liu Kai , Geng Xiaoyu , Liu Xiaoyan
Published: September 2022

Based on Network Agenda Setting Model, this study collected 42,516 media reports from Party Media, commercial media, and We Media of China during the COVID-19 pandemic. We trained LDA models for topic clustering through unsupervised machine learning. Questionnaires (N = 470) and social network analysis methods were then applied to examine the correlation between media network agendas and public network agendas in terms of explicit and implicit topics. The study found that the media reports could be classified into 14 topics by the LDA topic modeling, and the three types of media presented homogeneity in the topics of their reports, yet had their own characteristics; there was a significant correlation between the media network agenda and the public network agenda, and the We Media reports had the most prominent effect on the public network agenda; the correlation between the media agenda and the implicit public agenda was higher than that of the explicit public agenda. Overall, findings showed a significant correlation between network agendas among different media.
Effects of Contact Sports on Temporomandibular Disorders: An Observational Study
Authors: Crincoli Vito , De Biase Corrado , Cazzolla Angela Pia , Campobasso Alessandra , Dioguardi Mario , Piancino Maria Grazia , Mattia Luigi , Ribatti Domenico , Di Comite Mariasevera
Published: September 2022

The study investigated the prevalence of temporomandibular disorders in 100 competitive athletes in contact sports, equally grouped by the practiced game: Soccer (SoG), Rugby (RG), American Football (AFG), Boxing (BoG), Basketball (BaG), compared to a randomly control group of 20 non-athletes (CG). Symptoms and signs were examined according to the standardized Diagnostic Criteria for Temporomandibular Disorders through a questionnaire and clinical evaluation. Arthralgia showed significant differences between RG and CG and between AFG and CG (p < 0.05). Study groups reported masticatory muscle pain during function, neck and shoulder pain more frequently than CG, except for BoG. Closing click was significantly more present in study groups than CG, while crepitation was significantly higher only in RG and AFG. The deviation was wider in SoG, RG and AFG compared to CG (p < 0.05). Tukey’s multiple comparisons test showed a statistically significant reduction in right laterotrusion in RG vs. CG (p < 0.05); the comparison showed a decrease in right laterotrusion in RG vs. SoG and BoG (p < 0.05), a decrease in endfeel in RG vs. CG, BaG and AFG (p < 0.05). The data seem to support a relationship between the prevalence of TMD symptoms and signs in competitive athletes in contact sports, especially in RG and AFG compared to CG.
Estimations of Forest Stand Parameters in Open Forest Stand Using Point Cloud Data from Terrestrial Laser Scanning, Unmanned Aerial Vehicle and Aerial LiDAR Data
Authors: ARSLAN Adil Enis , İNAN Muhittin , ÇELİK Mehmet Furkan , ERTEN Esra
Published: September 2022

Two of the very basic forestry parameters, the Breast Height Diameter (DBH) and Tree Height (TH) are very effective when characterizing forest stands and individual trees. The traditional measurement process of these parameters takes a lot of time and consumes human power. On the other hand, 3D Point Cloud (PC) quickly provides a very detailed view of forestry parameters, because of the development of computer processing power and digital storage in recent years. PC data sources for forestry applications include Airborne LiDAR Systems (ALS), Terrestrial Laser Scanning (TLS) and most recently the Unmanned Air Vehicle (UAV). In this study, the PC datasets from these sources were used to study the feasibility of the DBH and TH values of a d development stage (i.e. DBH > 52 cm in mature stage) oak stand. The DBH and TH estimates are compared with the onsite measurements, which are considered to be fundamental truths, to their performance due to overall error statistics, as well as the cost of calculation and the difficulties in data collection. The results show that the computer data obtained by TLS has the best average square error (0.22 cm for DBH and 0,051 m for TH) compared to other computer data. The size of Pearson correlation between TLS-based and on-site-based measurements has reached 0.97 and 0.99 for DBH, respectively.
The communication educational needs analysis for improve communication ability: the case of psychiatric wards and emergency room nurse
Authors:   Korean Society of Nursing Research, Oh Eun Jung
Published: September 2022

Purpose : This study used a descriptive investigative design to explore educational needs of communication the purpose of establishing communication education program for nurses in psychiatric wards and emergency room.
Method : A survey was conducted on 190 nurses working in psychiatric wards and emergency room located in J, K and I cities. The collected data were analyzed using descriptive statistics, independent t-test, One-way ANOVA and paired t-test with the SPSS/WIN 21.0 program. For the purpose of analyzing educational need of communication, we analyzed data through an importance-performance analysis and the Borich needs assessment.
Results : The average importance of the communication education of nurses in psychiatric wards and emergency room was 3.60±0.36 out of 5, and the average communication ability was 3.47±0.31 out of 5. A t-test on the difference between IPA and Borich needs assessment showed the highest educational need of communication in the categories of Goal settings, and ‘Actively delivers own thoughts using body language and intonations’.
Conclusion : This is needed to develop on communication education program that can strengthen ‘Actively delivers own thoughts using body language and intonations’ communication for nurses in psychiatric wards and emergency room. Our study findings can be used as basic to design a communication education program suitable for nurses in psychiatric wards and emergency room to meet the educational of communication.
Development and application of simulation based high-risk newborn nursing education program for nursing students:Focus on scenario in the transient tachypnea of the newborn
Authors:   Korean Society of Nursing Research, Choi Eun Ju
Published: September 2022

Purpose : This study was conducted to develop and implement a simulation based high-risk newborn nursing education program for nursing student, and examine its effects on clinical competency, SBAR communication competency and learning confidence.
Methods : For this quasi-experimental study, 54 nursing students were recruited from 7 colleges. Twenty eight nursing students were assigned to experimental group and participated in the simulation based high-risk newborn nursing education program. Data were analyzed using the SPSS 22.0 program to perform χ²-test and t-tests between experimental and control groups.
Results : Clinical competency increased after simulation based high-risk newborn nursing education program, and there was a statistically significant difference(t＝6.05, p＜.001). SBAR communication competency increased after simulation based high risk high-risk newborn nursing education program and there was a statistically significant difference(t＝3.49, p ＝.001). However, there was no statistically significant difference in learning confidence after simulation based high-risk newborn nursing education program(t＝0.91, p＝.066).
Conclusion : These findings indicated that simulation based high risk high-risk newborn nursing education program is effective educational strategy for nursing students to learn clinical competency and SBAR communication competency
A scoping review of studies on nursing simulation education using standardized patients in Korea
Authors:   Korean Society of Nursing Research, Cho Hyeon Ah , Park Sun Jung
Published: September 2022

Purpose : This study is a scoping literature review on simulation education using domestic standardized patients based on the scoping literature review protocol presented by The Joanna Briggs Institute (JBI), and provides basic data for future simulation education using standardized patients.
Method : The literature search was conducted through 4 domestic sources (DBpia, KISS, KMBASE, NDSL), and documents published from January 2011 to December 2021. The main search terms were ‘standardized patient’ and ‘simulation’. As a result, 21 articles that met the selection criteria were selected.
Results : The results show that quantitative research was the largest with 17 (81.0%) out of a total of 21 articles, and that nursing simulation education as the main topic (title) had the most articles with 7 (33.3%). Communication ability was found to be the most common variable with 8 pieces (38.1%).
Conclusion : By means of the analysis results of the literature review on the subject range of simulation education using domestic standardized patients, it will be possible to use them as meaningful data to improve the effectiveness and quality of simulation education using standardized patients.
ВБИВСТВО, ДОВЕДЕННЯ ДО САМОГУБСТВА ЧИ ІНСЦЕНУВАННЯ САМОГУБСТВА? МЕТОДИКА РОЗСЛІДУВАННЯ
Authors: Корабель М. Г. , Павленко Т. А.
Published: September 2022

У науковій статті здійснено аналіз методики розслідування доведення до самогубства та інсценування самогубства з метою приховати умисне вбивство.

Методика розслідування досліджених кримінальних правопорушень є складною та вимагає проведення значної кількості слідчих дій, що спрямовані на отримання (збирання) доказів або їх перевірку в кримінальному провадженні. Спосіб доведення до самогубства є доволі складним щодо процесу розслідування кримінального провадження, оскільки факт жорстокого поводження, систематичного приниження або шантажу найчастіше відбувається в межах сімейних взаємин, без свідків та з необережною формою вини, коли особа не усвідомлювала наслідків своєї поведінки з потерпілим.

Не менш складним у розслідуванні обставин самогубства є сам процес інсценування з метою приховання умисного вбивства, коли злочинці намагаються інсценувати само-губство, через ретельне планування своїх дій або вже після вчинення кримінального правопорушення. Злочинець, усвідомлюючи невідворотність притягнення до кримінальної відповідальності, намагається відтворити подію самогубства в найменших деталях. Але навіть найідеальніший план інсценування допускає прорахунки. Аналіз механізму вчинення злочину в процесі формування версій вказує на обставини, що не відповідають послідовності подій під час самогубства. Встановлення факту інсценування самогубства зумовлено аналізом суперечливих подій під час самогубства: передсмертна записка, що не відповідає проблемам загиблого, або вчинення двох пострілів, кожен з яких є смертельним тощо.

Для виявлення такого діяння необхідно дотримуватися рекомендацій методики розслідування вбивств. Проведення всіх необхідних перевірок дозволяє встановити справж-ню причину смерті та правильно кваліфікувати вчинене.
ІНСТИТУТ ПРИЗНАЧЕННЯ БІЛЬШ М’ЯКОГО ПОКАРАННЯ, НІЖ ПЕРЕДБАЧЕНО ЗАКОНОМ: МИНУЛЕ, СЬОГОДЕННЯ, МАЙБУТНЄ
Authors: Коновальчик Є. О.
Published: September 2022

У статті наведено історико-правовий аналіз інституту призначення більш м’якого покарання, ніж передбачено законом. Досліджено мотиви законодавця щодо включення такої норми до закону про кримінальну відповідальність. Розглянуто невнесення до проекту нового Кримінального кодексу України можливості суду призначати більш м’яке покарання, ніж передбачено законом, з точки зору обмеження конституційного права особи, яка вчинила кримінальне правопорушення, на індивідуалізацію кримінальної відпові-дальності.
ПРОБЛЕМИ ЗАБЕЗПЕЧЕННЯ ПРИНЦИПУ СВОБОДИ ДОГОВОРІВ ПРО ПРАЦЮ В УМОВАХ ДИСТАНЦІЙНОЇ РОБОТИ НАУКОВО-ПЕДАГОГІЧНИХ ПРАЦІВНИКІВ
Authors: Шабанов Р. І. , Ждан М. Д.
Published: September 2022

Авторами вивчаються проблеми забезпечення принципу свободи договорів про працю в умовах дистанційної роботи науково-педагогічних працівників. Дистанційна робота як перспективний напрям піднесення виробничої сфери та прискорення економічного тання, потребує ефективного та дотичного використання, щоб не завдавати шкоди здоров’ю працівників та не нівелювати їхні традиційні професійні якості. Для унеможливлення прояву зазначених ризиків дистанційна робота потребує належного правового регулювання. На думку авторів, розповсюдження нормативних положень про дистанційну роботу не лише на відповідних працівників інформаційно-цифрової сфери не відповідає як принципу єдності і диференціації правового регулювання трудових відносин, так і принципу свободи договорів про працю. Автори констатують, що відповідно до положень підзаконних нормативно- правових актів про здійснення дистанційного навчання та практики їх втілення у закладах вищої освіти первинна трудова функція науково-педагогічних працівників в умовах дистанційної роботи була заміщена функцією адміністрування мережевого освітнього процесу з максимальним витісненням викладацької і наукової складової. У такий спосіб здійснюється недопустимий із точки зору принципу свободи договорів про працю вплив на волю науково-педагогічних працівників, які позбавляються можливості повноцінно реалізовувати власну трудову функцію та погоджуватись на зміну умов трудового договору в процесі переходу на дистанційне навчання. Авторами пропонується перенести положення про дистанційну роботу в окрему главу Кодексу законів про працю України, норми якої будуть розповсюджуватись лише на тих працівників, в яких здійснення трудової функції, пов’язаної з ІТ-сферою, є провідною. Автори також пропонують розробити Наказ Міністерства освіти і науки України “Про службу дистанційного навчання в закладах вищої освіти”, який буде регулювати положення про роботу відповідної служби, до завдань якої має належати організація дистанційної роботи в закладах вищої освіти, контроль, а також складання звітності про її виконання.
БАТЬКІВСЬКЕ СТАВЛЕННЯ ЯК ЧИННИК «Я-КОНЦЕПЦІЇ» ПІДЛІТКА
Authors: Крамченкова Віра
Published: September 2022

Актуальність У сучасному суспільстві особливої уваги потребує вивчення «Я-концепції» підлітка та зв’язку її компонентів із характеристиками батьківського ставлення.

Мета: дослідження особливостей «Я-концепції» підлітків у залежності від характеристик стилю батьківського ставлення.

Методи. Тест-опитувальник батьківського ставлення Г.Я. Варга та В.В. Століна, методика дослідження самоставлення В.В. Століна – С.В. Пантілєєва, проективна методика «Неіснуюча тварина» М.3. Друкаревич

РезультатиВизначенно стилі батьківського ставлення та виховних стратегій. Виявлено типи сімей із конструктивним та неконструктивним стилем батьківського ставлення. Встановлено особливості проекції «образу-Я» та характеристик самоставлення підлітків, як компонентів їх «Я-концепції» у залежності від конструктивності стилю батьківського ставлення Виявлено кореляційні зв’язки характеристик батьківського та материнського ставлення із компонентами самоставлення підлітків.

Висновки. Встановлено, що неконструктивний стиль батьківського ставлення представлений у матерів переважно інфантилізацією, відштовхуванням та симбіозом, а у батьків – відштовхуванням, авторитарною гіперсоціалізацією та інфантилізацією, тобто матері більш схильні до симбіотичного злиття, а батьки до авторитаризму.

Виявлено, що для підлітків з сімей з неконструктивним стилем батьківського ставлення характерні недостатня стабільність «Я-концепції», суперечливість «образу-Я» й неадекватність самооцінки, залежність від ситуативних впливів, зниження глобального самоставлення, самоповаги, аутосимпатії, самоприйняття й самозацікавлення. При цьому, прагнення до соціального визнання поєднується із пасивністю, несамостійністю та схильністю до агресії, як відповіді на тривожні очікування негативного ставлення з боку значущих соціальних фігур.

Показано, що на самоставленні підлітків позитивно позначається кооперація у батьківському ставленні, яка є більш впливовою, якщо проявляється у материнської поведінці ніж у батьківської. Порушення батьківського ставлення негативно пов’язане, як із глобальним самоставленням підлітків, так й з його компонентами.
ПСИХОЛОГІЧНІ ОСОБЛИВОСТІ СТАНОВЛЕННЯ КРЕАТИВНОЇ ПІДСИСТЕМИ СУБ’ЄКТА НАВЧАЛЬНО-ПРОФЕСІЙНОЇ ДІЯЛЬНОСТІ ГУМАНІТАРНОГО ПРОФІЛЮ
Authors: Саврасов Микола , Чернякова Олеся , Мартинова Карина
Published: September 2022

Актуальність дослідження. Проблема становлення креативності вчителя гуманітарного профілю набуває особливої виразності та значущості в умовах сучасних освітніх трансформацій.

Мета дослідження. Встановити та описати основні психологічні особливості динаміки становлення креативності майбутнього вчителя гуманітарного профілю в процесі навчання у виші.

Методи дослідження.Вибірка дослідження утворена студентами гуманітарного профілю ДВНЗ «ДДПУ» загальною кількістю 120 осіб та віком від 18 до 30 років. Використовується математико-статистична процедура аналізу ступеня статистичної достовірності розбіжностей середніх значень показників креативності. В якості методик дослідження використані скорочений варіант зображувальної (фігурної) батареї тесту Є. Торренса «Закінчи малюнок» та тест вербальної креативності С. Медніка.

Результати дослідження. Представлені основні результати аналізу ступеня статистичної достовірності розбіжностей середніх значень емпіричних показників креативності студентів гуманітаріїв на етапі першого, третього та п’ятого років навчання.

Висновки. Емпіричним шляхом встановлено, що позитивна динаміка даної системи властива лише вербальній креативності та забезпечується за рахунок зростання більшості її показників виключно на завершальному етапі, а саме показників гнучкості, оригінальності та розробленості вербальної креативності. Виявлено зростання варіативності вербальних асоціацій, рівня їх нетиповості та прагнення до втілення вербального творчого задуму, його зрозумілості та доступності для оточуючих ймовірно викликане поглибленням особистісно-професійного становлення студента гуманітарного профілю. Доведено, що образна складова креативної психічної системи суб’єкта навчально-професійної діяльності гуманітарного профілю протягом професійної підготовки у виші демонструє негативні тенденції відсутності достовірного зростання та епізодичного достовірного занепаду, основними причинами таких незадовільних тенденцій може виступати вербальна когнітивна перевантаженість змісту навчально-професійної діяльності студентів-гуманітаріїв.