bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatiotemporal optical vortex harmonics in an epsilon-near-zero ITO film
Authors: Jiang Yu , Zhang Chaojin , Wu Xun , Liu Chengpu
Published: February 2025

When an intense few-cycle spatiotemporal optical vortex (STOV) laser propagates through an indium tin oxide (ITO) thin film, the vortex harmonic generations are theoretically investigated by numerically solving the full-wave Maxwell-paradigmatic-Kerr equations. It is shown that the fork-shaped dislocation in the spatiotemporal domain becomes center-asymmetric, and the accompanying harmonic radiation is significantly enhanced when the incident laser frequency is within the epsilon-near-zero (ENZ) frequency region of the ITO film. Specially, the accompanying harmonic radiation presents an obvious bright stripe of spatiospectral tilt as the consequence of a spatial chirp, and the corresponding phase spatiotemporal profile of harmonic radiation displays multiple spiral phase periods of 2π. From these distributions of bright stripes and phase spatiotemporal profiles, one can directly determine the topological number of each order harmonic.
Tonic ubiquitination of the central body weight regulator melanocortin receptor 4 (MC4R) promotes its constitutive exit from cilia
Authors: Ojeda-Naharros Irene , Das Tirthasree , Castro Ralph A. , Bazan J. Fernando , Vaisse Christian , Nachury Maxence V.
Published: February 2025

The G protein-coupled receptor (GPCR) melanocortin receptor 4 (MC4R) is an essential regulator of body weight homeostasis. MC4R is unusual among GPCRs in that its activity is regulated by 2 opposing physiological ligands, the agonist ⍺-MSH and the antagonist/inverse agonist AgRP. Paradoxically, while MC4R localizes and functions at the cilium of hypothalamic neurons, the ciliary levels of MC4R are very low under unrestricted feeding conditions. Here, we find that the constitutive activity of MC4R is responsible for the continuous depletion of MC4R from cilia and that inhibition of MC4R’s activity via AgRP leads to a robust accumulation of MC4R in cilia. Ciliary targeting of MC4R is mediated by its partner MRAP2 and the constitutive exit of MC4R from cilia relies on the sensor of activation β-arrestin, on ubiquitination, and on the BBSome ciliary trafficking complex. Thus, while MC4R exits cilia via conventional mechanisms, it only accumulates in cilia when its activity is suppressed by AgRP.
Comparison of anonymization techniques regarding statistical reproducibility
Authors: Pau David , Bachot Camille , Monteil Charles , Vinet Laetitia , Boucher Mathieu , Sella Nadir , Jegou Romain
Published: February 2025

Background

Anonymization opens up innovative ways of using secondary data without the requirements of the GDPR, as anonymized data does not affect anymore the privacy of data subjects. Anonymization requires data alteration, and this project aims to compare the ability of such privacy protection methods to maintain reliability and utility of scientific data for secondary research purposes.

Methods

The French data protection authority (CNIL) defines anonymization as a processing activity that consists of using methods to make impossible any identification of people by any means in an irreversible manner. To answer project’s objective, a series of analyses were performed on a cohort, and reproduced on four sets of anonymized data for comparison. Four assessment levels were used to evaluate impact of anonymization: level 1 referred to the replication of statistical outputs, level 2 referred to accuracy of statistical results, level 3 assessed data alteration (using Hellinger distances) and level 4 assessed privacy risks (using WP29 criteria).

Results

87 items were produced on the raw cohort data and then reproduced on each of the four anonymized data. The overall level 1 replication score ranged from 67% to 100% depending on the anonymization solution. The most difficult analyses to replicate were regression models (sub-score ranging from 78% to 100%) and survival analysis (sub-score ranging from 0% to 100. The overall level 2 accuracy score ranged from 22% to 79% depending on the anonymization solution. For level 3, three methods had some variables with different probability distributions (Hellinger distance = 1). For level 4, all methods had reduced the privacy risk of singling out, with relative risk reductions ranging from 41% to 65%.

Conclusion

None of the anonymization methods reproduced all outputs and results. A trade-off has to be find between context risk and the usefulness of data to answer the research question.
Rethinking neglected tropical diseases: A shift towards more inclusive and equitable terminology
Authors: Grijsen Marlous L. , Yangaza Yonah E. , Kadri Al , Strub Fidel , Freeman Esther E. , Enbiale Wendemagegn
Published: February 2025

Neglected tropical diseases (NTD) refer to a group of 21 diseases that disproportionally affect impoverished communities in low- and middle-income countries (LMIC) [1]. NTD collectively impact 1.7 billion people, which is about 20% of the world’s population [1]. Each year, NTD account for more than 200,000 deaths, with millions left disabled and disfigured due to insufficient access to care and affordable treatment, often leading to social exclusion, stigmatization and discrimination. Although the term NTD has successfully directed funding and resources towards these conditions and encouraged global partnerships and high-level policy initiatives, the term may also have unintended negative consequences. In this paper, we aim to explore the term NTD and stimulate a dialogue that re-evaluates its meaning into more inclusive and equitable language.
Clinical manifestations associated with the chronic phase of Chikungunya Fever: A systematic review of prevalence
Authors: Santiago Raphael Augusto , Bavaresco Suelen Pereira Priante , Citrangulo Sheyla Goulart , Medronho Roberto de Andrade , Sampaio Vanderson , Costa Antônio José Leal
Published: February 2025

Introduction

The aim of this systematic review of prevalence is to observe and discuss the clinical manifestations of Chikungunya Virus disease in its chronic phase.

Methods

To be eligible, the observational studies should accompany the individuals for at least six months. The research was conducted using electronic databases MEDLINE and EMBASE. The methodological quality was evaluated using the “Joanna Briggs Institute’s critical appraisal checklist for studies reporting prevalence data” tool.

Results

The search has found 175 articles. The application of the inclusion criteria defined a total of 29 selected studies. From the included studies, only one did not present arthralgia as a prevalent symptom in the chronic phase. Other signs and symptoms observed were: fatigue; sleep disorders; myalgia; skin lesions; depression; digestive disorders.

Conclusion

Because it is an often incapacitating symptom, arthralgia can affect the individuals’ quality of life, with implications in their social and work life. Since the chronic phase is common in infected individuals, all levels of health care should be prepared to monitor, in the medium to long term, the patients affected by this condition.
Temporal shifts in dengue epidemic in Guangdong Province before and during the COVID-19 pandemic: a Bayesian model study from 2012 to 2022
Authors: Xu Jiaqing , Tan Xiaohua , Quan Yi , Gong Dexin , Deng Hui , Zhao Jianguo , Huang Xing , Zhang Yingtao , Ren Zhoupeng , Rong Zuhua , Zeng Weilin , Li Xing , Zheng Wenyuan , Xiao Shu , Xiao Jianpeng , Zhang Meng
Published: February 2025

Background

During the coronavirus disease 2019 (COVID-19) pandemic, the implementation of public health intervention measures have reshaped the transmission patterns of other infectious diseases. We aimed to analyze the epidemiological characteristics of dengue in Guangdong Province, China, and to investigate the temporal shifts in dengue epidemic in Guangdong Province during the COVID-19 pandemic.

Methods

Based on the data of dengue reported cases, meteorological factors, and mosquito vector density in Guangdong Province from 2012 to 2022, wavelet analysis was applied to investigate the relationship between the dengue incidence in Southeast Asian (SEA) countries and the local dengue incidence in Guangdong Province. We constructed the dengue importation risk index to assess the monthly risk of dengue importation. Based on the counterfactual framework, we constructed the Bayesian structural time series (BSTS) model to capture the epidemic trends of dengue.

Results

Wavelet analysis showed that the local dengue incidence in Guangdong Province was in phase correlation with the dengue incidence of the prior month in relative SEA countries. The dengue importation risk index showed an increasing trend from 2012 to 2019, then decreased to a low level during the COVID-19 pandemic. From 2020 to 2022, the average annual number of reported imported cases and local cases of dengue in Guangdong Province were 26 and 2, respectively, with a decrease of 95.62% and 99.94% compared to the average during 2017-2019 (594 imported cases and 3,118 local cases). According to BSTS model estimates, 6557 local dengue cases may have been reduced in Guangdong Province from 2020 to 2022, with a relative reduction of 99.91% (95%CI: 98.85-99.99%).

Conclusion

The incidence of dengue in Guangdong notably declined from 2020 to 2022, which may be related to the co-benefits of COVID-19 intervention measures and the intensified interventions against dengue during that period. Furthermore, our findings further supported that dengue is not currently endemic in Guangdong.
Crankshaft high cycle bending fatigue test method based on the combined extended Kalman filtering algorithm and different failure criterion parameters
Authors: Wei Zhang , Ruidong Yan , Sun Songsong , Xiaolin Gong , Zhentao Liu
Published: February 2025

In this paper, an accelerated bending fatigue test method for the crankshaft was proposed based on the combination of the extended Kalman filtering algorithm method (EKF) and different failure criterion parameters. First the intrinsic frequency of the system and the fatigue crack depth were chosen to be the failure criterion parameters based on the test regulation and the theory of fracture mechanics. Then the extended Kalman filtering method was adopted in predicting the remaining high cycle fatigue life of the crankshaft during the experiment process. Finally the predicted fatigue life was selected to replace the actual test results for the key fatigue property parameter analysis. Based on this research, the time duration of the test was reduced obviously without affecting the key analysis parameters obviously. In addition, compared with the intrinsic frequency of the system, the fatigue crack depth is more suitable to be selected as the failure criterion to provide more reasonable enhancing effect. The main conclusions draw from this paper can provide some theoretical guidance for the design and manufacturing process of the part.
A meta-analysis of the impact of TOE adoption on smart agriculture SMEs performance
Authors: Nagy Adrian , Tumiwa Johan , Arie Fitty , László Erdey , Alsoud Anas Ratib , Al-Dalahmeh Main
Published: February 2025

Background

Agricultural SMEs face distinct challenges due to factors such as weather, climate change, and commodity price changes. Technology has become essential in helping SMEs overcome these challenges and grow their businesses. The relationship between technology and SMEs in the agriculture sector covers various aspects, such as using hardware and software, digital applications, sensors, and e-commerce strategies to be examined in further depth through literature study.

Problem statement

The implementation of the TOE (technology, organization, and environment) framework in smart agriculture faces several challenges. To overcome these challenges, an integrated approach is needed that involves technological capacity building, organizational management changes, and adequate policy and infrastructure support to help SMEs in the agricultural sector develop their businesses.

Objectives

This research aims to demonstrate and identify how TOE plays an important role in the performance of SMEs, particularly with regard to agriculture in order to improve agricultural productivity, efficiency, and sustainability while enabling access to broader markets in several countries. This study employs a meta-analysis method using a quantitative approach taken by each publication, which typically used SEM.

Methods

PRISMA technique was used to examine evidence from clinical trials, and clinical significance was determined using the GRADE approach. Statistical analysis was performed using the Fisher test to combine the results of several studies and Cohen’s approach to interpreting effect sizes.

Findings

The results of this study are in line with the findings of 27 previous studies which showed a direct positive relationship between TOE construction and the performance of agricultural SMEs, with variables including technological factors, organizational factors, environmental factors, and SME performance. The synergy between technology adoption by agricultural SMEs and Industry 4.0 can increase connectivity and automation in the agricultural sector. However, it is important to remember that adopting TOE to realize the smart agriculture concept has its own challenges and risks, such as resource management (technology), good organizational management (organization), and internal and external organizational environments (environments), including intense competition

Research implication

TOE adoption improves access to information about competitors and customers, providing practitioners and decision-makers with a clearer understanding. It enables focus on factors with a significant impact on TOE adoption, so that they are more independent in developing effective business concepts that are adaptive to the era of agricultural technology 4.0.
Translation, content validity and internal structure of the Brazilian version of the Adolescent Resilience Questionnaire (B-ARQ)
Authors: Gomes Genara Brum , Gatti-Reis Luisa , Perazzo Matheus França , Araújo Marisa Alves , Mattos Flávio Freitas , Gartland Deirdre , Paiva Saul Martins , Pordeus Isabela Almeida
Published: February 2025

Resilience refers to one’s ability to face life’s challenges and achieve positive outcomes, and has drawn increasing interest from researchers and policymakers. The Adolescent Resilience Questionnaire (ARQ) is a measure that assesses resilience in adolescents according to a multidimensional perspective, encompassing its several different domains. This cross-sectional study aimed to translate and evaluate the measurement properties of the Brazilian version of the ARQ (B-ARQ) for use with Brazilian adolescents. Two native speakers in Brazilian Portuguese language who were also fluent in English language translated the ARQ from English into Portuguese. A committee of experts in validation studies compared the translated versions. A summarized version was produced and back-translated by a translator native of the English language and fluent in Portuguese. The B-ARQ was pre-tested in a sample of 21 adolescents. An expert committee considered the suggestions and defined the final version of the instrument, which was tested in a sample of 210 adolescent students from public and private schools in the city of Dom Pedrito, Brazil. All students filled out the 88-item instrument as well as a socio-demographic questionnaire. Statistical analysis included descriptive statistics of all variables (frequency distribution, floor, ceiling effects), internal consistency, and confirmatory factor analysis of the version with 88 items and the shortened version with 49 items. The short version with 49 items was validated in a cross-sectional study in an adolescent population of high school students using exploratory factor analysis in the Unites States. The 88-item ARQ had poor structural validity with unsatisfactory model fit indices. Therefore, the investigation focused on the short 49-item version of the ARQ (B-ARQ-SV). The final model presented satisfactory RMSEA = 0.042 (p = 0.994, 90% CI: 0.037–0.047) and SRMR of 0.076, despite the low CFI (0.878). The internal consistency was estimated with McDonald’s Omega for each factor: Confidence (ω = 0.480), Negative Cognition (ω = 0.588), Empathy/tolerance (ω = 0.295), Emotional insight (ω = 0.425), Social Skill (ω = 0.235), Family Domain Connectedness (ω = 0.785), Family Domain Availability (ω = 0.847), Peers Domain Connectedness (ω = 0.719), Peers Domain Availability (ω = 0.402), School Domain Supportive environment (ω = 0.677), School Domain Connectedness (ω = 0.013), Community Domain Connectedness (ω = 0.791). One scale showed a ceiling effect (frequency higher than 15.0%), but we identified no critical floor effect. The B-ARQ-SV is a valid (in terms of content and structural validity) and reliable (in terms of internal consistency) measurement instrument to assess resilience in Brazilian adolescents.
Uncovering the genetic basis of milk production traits in Mexican Holstein cattle based on individual markers and genomic windows
Authors: Cortes-Hernández José G. , García-Ruiz Adriana , Peñagaricano Francisco , Montaldo Hugo H. , Ruiz-López Felipe J.
Published: February 2025

The objective of this study was to evaluate the proportion of genetic variance explained by single nucleotide polymorphism markers, individually or clustered in 1, 2, and 5 Mb windows, for milk yield, fat yield, protein yield, fat content, protein content, and somatic cell score in Mexican Holstein cattle. The analysis included data from 640,746 lactation records of 358,857 cows born between 1979 and 2019, distributed in 353 herds in 18 states of Mexico. The analysis included genotypic data on 7,713 cows and 577 sires, with information on 88,911 markers previously imputed and filtered by quality control. Genomic scans via the single-step genomic best linear unbiased prediction method were performed using BLUPF90 software. A total of 162 markers were significantly associated (p<0.01) with the phenotypic traits evaluated, and the SNP markers were distributed across chromosomes 1, 3, 5, 6, 10, 12, 14, 16, 18, 20, 22, and 29. When the size of the genomic windows was increased from 1 to 5 Mb, a greater proportion of genetic variance was explained by the SNPs within the window, and a greater number of windows explained more than 1% of the genetic variance. The most significant regions were associated with two or more phenotypic traits, such as one region on chromosome 14 that harbors the DGAT1, EXOSC4, PPP1R16A, and FOXH1 genes, which affect all the traits under study. In general, the utilization of genomic windows resulted in a greater proportion of genetic variance explained by milk production traits.
Do health professionals know about overdiagnosis in screening, and how are they dealing with it? A mixed-methods systematic scoping review
Authors: Piessens Veerle , Van den Bruel Ann , Piessens An , Van Hecke Ann , Brodersen John Brandt , Lauwerier Emelien , Stul Florian , De Sutter An , Heytens Stefan
Published: February 2025

Introduction

Medical screening is a major driver of overdiagnosis, which should be considered when making an informed screening decision. Health professionals (HPs) often initiate screening and are therefore responsible for informing eligible screening participants about the benefits and harms of screening. However, little is known about HPs’ knowledge of overdiagnosis and whether they are prepared to inform screening candidates about this risk and enable people to make an informed screening decision.

Methods

This is a systematic review of studies examining HPs’ knowledge and perception of overdiagnosis, whether it affects their position on offering screening, and their willingness to inform screening candidates about overdiagnosis. We conducted systematic searches in MEDLINE, Embase, Web of Science, Scopus, CINAHL, and PsycArticles without language restrictions. Two authors analysed the qualitative and quantitative data separately. Confidence in the findings of the qualitative data was assessed using the GRADE-CERQual approach.

Results

We included 23 publications after screening 9786 records. No studies directly examined HPs’ knowledge of overdiagnosis. HPs’ perceptions of overdiagnosis varied widely, from considering it a significant harm to seeing it as negligible. This seems linked to their overall beliefs about the benefits and harms of screening and to their position on offering screening, which varies from discouraging to actively promoting it. HPs also hold diverging approaches to informing screening candidates about overdiagnosis, from providing detailed explanations to limited or no information.

Conclusion

There is a lack of research on HPs’ knowledge of overdiagnosis, however, HPs who do know about overdiagnosis attribute substantially different levels of harm to it. This seems intertwined with their overall beliefs about the benefits of screening, their position towards offering screening, and their willingness to inform screening candidates about overdiagnosis. This has important implications for the public’s right to evidence-based information and compromises an individual’s right to make an informed screening decision.
Research on the relationship between key risk factors of university emergencies based on ISM-MICMAC
Authors: Li Yufei , Liu Xiaoyun , Hu Nanyan , Li Xuexue
Published: February 2025

In order to accurately analyze the interaction among the risk factors of university emergencies, firstly, based on the key performance indicator (KPI) concept, by initially extracting risk factors, identifying initial risk factors, and correcting initial risk factors, and the risk factors of emergencies in universities were divided into three categories: human factors, environmental factors, and management factors, and 18 key risk factors of emergencies in universities, including psychological problems, weak legal awareness and lack of safety awareness, were subdivided and determined. Secondly, the interpretive structure model (ISM) was used to construct a multi-layer hierarchical model of the relationship between university emergencies risk factors, clarified the hierarchical affiliation between the risk factors of university emergencies, divided the risk factors of university emergencies into surface direct factors, middle indirect factors and deep fundamental factors, and analyzed the coupling effect of various risk factors on university emergencies. Thirdly, combined with the matrix impacts cross-reference multiplication applied to a classification (MICMAC), the driving force and dependence force of each risk factor of university emergencies were obtained, and the risk factors of university emergencies were divided into spontaneous factors, independent factors, dependent factors, linkage factors, etc. 4 categories, and targeted governance and prevention measures were proposed for different types of risk factors. Finally, the research results will help universities to accurately identify, warn and manage the key risks of emergencies, and provide a reference for the management of emergencies in universities.
Cerebrovascular accidents association between serum trace elements and toxic metals level, a case-control study
Authors: Jamebozorgi Khosro , Kooshki Alireza , Saljoughi Mahbobeh , Sanjari Mohamadjavad , Ahmadi Zahra , Mosavi Mirzaei Seyed Mohammad
Published: February 2025

Background

Cerebrovascular accidents (CVAs) are among the most common complications of patients today. As the prevalence of ischemic CVAs rises, detecting related risk factors is crucial. Metal concentration has previously been considered a major risk factor in several neural complications, and in this study, we will investigate this.

Methods

In this case-control study, 70 CVA (clinically approved ischemic stroke cases by imaging and NIH Stroke Scale (NIHSS)) and 70 individuals with no history of CVA controls were enrolled as the control group. The serum level of several metals, including Fe (Iron), Co (Cobalt), Ni (Nickel), Cu (copper), Zn (Zinc), Mn (Manganese), Pb (lead), Hg (Mercury), has been assessed using Inductively coupled plasma mass spectrometry (ICP-MS) method. Logistic regression (LR) has also been used to determine the association between metals’ levels and CVA occurrence.

Results

As the mean age of the CVA group was 48.68  ±  15.25 years and for the non-CVA group was 47.89 ± 9.65 years, the result indicated that the serum level of Cu and Pb has been statically higher in the CVA group (respectively; P  <  0.001 and P  =  0.002) and Ni level was significantly lower (P  =  0.003). Other measured metals’ levels (Fe, Co, Ni, Mn, Hg) were not significantly different between CVA and non-CVA groups. In the LR model, all Cu, Pb, and Zn metals had a P value of 0.03 and an odd ratio (OR) and confidence interval (CI) of 1.34 (1.02–1.75), 1.19 (1.01–1.39) and 1.01 (1.001–1.02) respectively.

Conclusion

Given that some metals are associated with a higher risk of CVA, researchers and physicians must better understand the risk factors and causes of the burden of CVA. However, further studies with a larger population and investigation of the exact pathogenesis of these metals are needed.
Media ecology, genetics and society: A possible contribution from Neil Postman’s Technopoly to the ethical debate surrounding ancient human DNA studies
Authors: Frassetto Gabriel , Okumura Mercedes
Published: February 2025

Ancient DNA (aDNA) research has been intertwined with technology since its very beginning. Recognized for its potential to unveil insights into history and evolution, the field has been regarded as ‘revolutionary’ – and even capable of solving a myriad of questions still left open. Yet, critics range from ethical implications of the destruction of human remains – a non-renewable source of biological, cultural and spiritual significance – to the perceived overvaluation of genetics as a more reliable source of knowledge than other disciplines. Additionally, native communities (often sought for these studies) voiced concerns about biocolonialism, emphasizing the potential harm to their identity and both territorial and repatriation claims. Given this context, this article explores possible contributions from Postman’s Technopoly to the field’s ongoing discussions. What transformations has such technology brought about? Have inequalities been perpetuated (or even exacerbated)? How might understanding media ecology contribute to navigating these complexities, after all?
ET Russian: Redefining illustration through multisensory storytelling
Authors: Fernandes Deanne Genevieve
Published: February 2025

This short text highlights how ET Russian reshapes traditional illustration by weaving together multisensory techniques to create accessible, immersive narratives. Grounded in disability justice and queer identity, Russian’s work goes beyond visual art, blending performance, sound, texture and tactile elements. This approach invites underrepresented communities, especially disabled and LGBTQ+ individuals, into the storytelling process. By pushing the boundaries of accessibility and identity, Russian’s art challenges viewers’ perceptions and demonstrates how multisensory storytelling can evoke empathy and drive change within the field of illustration.
Comparative Analysis of Popular CNN Based Deep Learning Models for Tree Trunk Detection in Orchards
Authors: Cejnek Matous , Vrba Jan , Jura Jakub , Trnka Pavel , Zeleny Lubor
Published: February 2025

This study compares machine vision deep learning models based on convolutional neural networks to detect tree trunks in orchards from camera images, with a primary focus on apple trees. Two distinct datasets are used, one original with apple trees and another publicly available featuring vineyard trunks. Multiple deep learning models are tested and compared in order to evaluate their efficacy in tree trunk detection. Research not only provides insight into the performance of various models but also serves as a valuable benchmark for assessing achievable results in orchard-based machine vision applications. The findings contribute to the field’s understanding of tree trunk detection, facilitating advancements in agricultural automation.
A PARCERIA ENTRE O TOXICÔMANO E A DROGA
Authors: Santos Luzia Silva dos , Ferreira Renata Wirthmann G. , Nunes Tiago Ribeiro
Published: February 2025

Propomos investigar no presente estudo a parceria entre o toxicômano e a droga. Para tanto, examinaremos, a partir das elaborações psicanalíticas, vinhetas de entrevistas realizadas com pacientes da Clínica de Reabilitação Fundação Jovem na cidade de Catalão/GO. Ao todo, oito pacientes (todos do sexo masculino, entre 19 e 53 anos de idade) consentiram em participar das entrevistas que foram realizadas entre os meses de julho a setembro de 2014. O presente trabalho se justifica por permitir esclarecer algumas relações existentes entre a parceria do toxicômano e a devastação do corpo com a conseqÃ¼ente ruptura dos laços sociais que dela decorre. Ao final, propomos que as políticas públicas de combate às drogas sejam revisadas a partir do conceito lacaniano de gozo.
CONTRIBUIÇÕES DE SIGMUND FREUD SOBRE A RELIGIÃO
Authors: Martes Jeanhderson Morais , Martins Paulo César Ribeiro
Published: February 2025

O objetivo deste artigo é descrever as contribuições de Sigmund Freud sobre a religião. Foi utilizado o método dedutivo para chegarmos a premissas descritivas a partir das obras freudianas, tendo como procedimento a pesquisa bibliográfica com abordagem teórica. O problema proposto consiste em como Freud concebe a religião. O estudo justifica-se pela recuperação histórica da participação freudiana sobre o tema. A religião para Freud tem uma influência considerável na sociedade com o intuito de conceder consolo diante do desamparo da vida. Por isso, pode ser tida como uma ilusão que possui a finalidade de conferir ao homem um propósito de vida.
A ALIANÇA TERAPÊUTICA NO PACIENTE DIAGNOSTICADO COM TRANSTORNO DE PERSONALIDADE BORDERLINE
Authors: Geremia Lisiane , Benetti Silvia Pereira da Cruz , Esswein Georgius Cardoso , Bittencourt Aline Alvares
Published: February 2025

O objetivo deste trabalho foi investigar a Aliança Terapêutica na psicoterapia psicanalítica de uma paciente com Transtorno de Personalidade Borderline. Trata-se de um estudo de caso sistemático, que inclui a análise de 12 sessões de um total de 34 sessões de psicoterapia. As sessões foram avaliadas através de anotações clínicas e do instrumento WAI-O (Working Alliance Inventory, Observer Form) composto pelas subescalas Vínculo, Tarefa e Objetivos. Os resultados indicaram o desenvolvimento de uma boa Aliança Terapêutica, especialmente na subescala Vínculo. Assim, a ligação entre paciente e terapeuta foi mais importante para a adesão da paciente à psicoterapia do que tarefas e objetivos acordados. Destaca-se a importância de pesquisas de processo psicoterápico para identificar os ingredientes ativos na manutenção dos tratamentos.
Factorial structure, measurement invariance and reliability of the Emotion Regulation Checklist (ERC) in a sample of Portuguese parents
Authors: Fernandes Marília , Morais Inês , Santos Carolina , Gudes Maryse , Ribeiro Olívia , Fernandes Carla , Pires Eva , Santos Ana Filipa , Santos António J. , Veríssimo Manuela
Published: February 2025

Emotion regulation is important for socioemotional and mental health development, with lifelong implications. The Emotion Regulation Checklist (ERC; Shields & Cicchetti, 1997) is a widely used tool to assess emotional regulation and dysregulation in children. Despite wide use and translate into several languages, inconsistent findings have been found in its factorial structure across studies. This study addresses this gap by examining the factorial structure, reliability, and measurement invariance of the ERC in a Portuguese sample. A sample of 789 parents (mostly mothers, 90.9%) with children between 3 to 12 years old (49.3% preschoolers and 50.7% School-age) completed the scale. Confirmatory Factor Analysis (CFA) revealed that the original two-factor model (Emotion Regulation and Lability/Negativity) reached an acceptable fit, however three items had to be removed, and two item residuals correlated. Full invariance was achieved regarding boys and girls. While, regarding age, only configural invariance was achieved, meaning that, different loadings should be expected between preschool and school-age children. Considering the final model the Cronbach’s alphas (α) was .66 for Emotion Regulation and .80 for Lability/Negativity. These findings provide some support for the use of the Portuguese parents’ version of the ERC with preschool and school-age children.
Umsetzung von verbindlichen Flächensparzielen im Rahmen der räumlichen Planung
Authors: Blecken Lutke , Böhnke Robert , Götze Gabriel , Gutsche Jens-Martin , Köck Wolfgang , Preuß Thomas
Published: February 2025

New land use for settlement and transport exceeds the federal government’s “below 30 ha/day” target. Varial federal states have incorporated this target into their own state targets. However, there has not been any operationalization in the form of binding targets at state, regional or municipal level to date. Operationalizing a binding quota system could involve trading land certificates (using an environmental economic approach) and spatial planning (using a regulatory approach). The analysis of land certificates trading was conducted through the “land trading simulation game” pilot project. However, there is no implementation or organizational model for operationalization using a spatial planning approach. To fill this gap, this paper presents a concept for implementing binding land-saving targets within the framework of spatial planning. It contains statements on the determination of a binding total volume of land quotas, the distribution between the federal and state governments, the distribution at state level to municipalities, the application of the quotas in planning procedures, the administration by “quota authorities” and the necessary accompanying measures.
Meditative elements in contemporary Ukrainian music
Authors: Serhaniuk Liubov , Kazymyriv Khrystyna , Maskovych Tetiana , Taran Iryna , Bardashevska Yaroslava
Published: February 2025

The study of meditativeness in music is of particular interest to scholars, especially when the interaction of unique factors can lead to the emergence of new patterns or a profound rethinking of long-established norms or laws. This phenomenon is evident in Ukrainian music of the last third of the 20th century and the early 21st century. The aim of this article is to uncover the potential of meditativeness as a style-forming phenomenon (using examples from Ukrainian compositional work) and to identify its analogs, which play a significant role in its practical implementation and subsequent interpretation. An important aspect is also establishing broader connections with phenomena rooted in Ukrainian music, thought, and culture, particularly those currently identified as “new sacred”. This analysis has led to an approach that allows tracing connection between contemporary understandings of meditation in music and the archetypal and conceptual layers of Ukrainian musical culture, as reflected in musical thought, poetics, and the core stylistic models of individual works. In this way, the classification of a particular piece as belonging to the meditative sphere depends on the interpretation of stylistic techniques by both artists and researchers as elements of implementing a specific concept. At the same time, the very idea of meditative perception of the world and the related concepts can be seen as a significant style-modulating factor. This factor is grounded in a substantial reexamination of various academic genres or artistic concepts, which can be defined as artistic experimentation.
21st century skills model: Secondary school physical education and sports lesson curriculum
Authors: Yavuz Sevilcan , Yavuz Ulfet , Baydar Arıcan Hacer Özge
Published: February 2025

Developing technology, globalisation and rapidly increasing population with the globalising world have brought about changes in the social structure. With these changes, the skills that individuals are expected to have are also being renewed and updated. These renewals and updates are also reflected in the educational policies of the states and cause changes in the legislation and regulations related to education. In this study, which was conducted to analyse the achievements of the “Physical Education and Sports Course Curriculum” within the scope of the ‘Research Report on 21st Century Skills and Values’ prepared by the Ministry of National Education, Board of Education and Board of Discipline, document analysis was used and the findings obtained were subjected to content analysis. As a result of the analysis, it was determined that the outcomes in the “Physical Education and Sports Curriculum” were associated with 7 basic skills and 46 sub-skills within the framework of the “21st Century Skills Model”, the skills were repeated 132 times in the outcomes and 11 values surrounding all of the skills were included in the outcomes in the programme.
(Extended English summary is at the end of this document)
Özet
Küreselleşen dünya ile birlikte gelişen teknoloji, globalleşme, hızla artan nüfus toplumsal yapıdaki değişimi beraberinde getirmiştir. Yaşanan bu değişimlerle birlikte bireylerin sahip olmaları beklenen beceriler de yenilenmekte ve güncellenmektedir. Bu yenilenme ve güncellemeler, devletlerin eğitim politikalarına da yansıyarak, ülkelerin eğitim ile ilgili mevzuat ve yönetmeliklerinde de değişimlere neden olmaktadır. Milli Eğitim Bakanlığı Talim ve Terbiye Kurulu Başkanlığı tarafından hazırlanmış olan “21. Yüzyıl Becerileri ve Değerlere Yönelik Araştırma Raporu” kapsamında “Beden Eğitimi ve Spor Dersi Öğretim Programı”nın kazanımlarının analiz edilmesi amacıyla yapılan bu çalışmada doküman incelemesinden yararlanılmış ve elde edilen bulgular içerik analizine tabi tutulmuştur. Yapılan analiz sonucunda, “Beden Eğitimi ve Spor Öğretim Programı”nda yer alan kazanımlar, “21. Yüzyıl Beceri Modeli” çerçevesinde yer alan 7 temel beceri ve 46 alt beceri ile ilişkilendirilerek becerilerin kazanımların içerisinde 132 kez tekrarlandığı ve becerilerin tümünü saran 11 değerin programdaki kazanımlarda yer aldığı tespit edilmiştir.
Temporary bilateral clamping of renal arteries induces ischemia–reperfusion: A new pig model of acute kidney injury using total intravenous anesthesia
Authors: Guilpin Axel , Magnin Mathieu , Aigle Axel , Ayoub Jean‐Yves , Schuhler Timothée , Lac Romain , Marchal Thierry , Brichart Thomas , Hammed Abdessalem , Louzier Vanessa
Published: February 2025

Ischemia‐reperfusion (IR) is a leading cause of acute kidney injury (AKI), and pigs are commonly used in preclinical AKI models. However, existing models often vary in the methods used to induce ischemia, and the resulting AKI tends to be mild‐to‐moderate. Moreover, follow‐up is often performed under volatile anesthesia, which, in contrast to total intravenous anesthesia (TIVA), can induce malignant hyperthermia and cause hemodynamic instability. Here we present a novel surgical model of IR‐induced AKI using bilateral renal artery clamping under TIVA. Anesthesia was induced via TIVA with diazepam, ketamine, and morphine. After retroperitoneal exposure, the renal arteries were isolated and clamped with a plastic tube for 90 min, followed by 8 h of reperfusion. The IR group (n = 6) was compared with a Sham group (n = 5) that underwent the same procedure without IR. The IR group developed moderate‐to‐severe AKI as evidenced by reduced glomerular filtration, a 158% increase in plasma creatinine versus 21% in the Sham group, and elevated neutrophil gelatinase‐associated lipocalin levels (+280% in IR vs. 0% in Sham), indicating tubular injury. Histopathology confirmed these findings. Thus, this preclinical model successfully induced moderate‐to‐severe AKI in pigs. The TIVA anesthetic protocol offered several advantages compared to halogenated gas anesthesia.
Myofiber structure, sarcoplasmic reticulum Ca2+ handling, and contractile function after muscle‐damaging exercise in humans
Authors: Handegard V. , Lunde P. K. , Frisk M. , Seynnes O. , Ørtenblad N. , Louch W. E. , Paulsen G. , Raastad T.
Published: February 2025

Exercise‐induced muscle damage (EIMD) is characterized by a severe and prolonged decline in force‐generating capacity. However, the precise cellular mechanisms underlying the observed long‐lasting decline in force‐generating capacity associated with EIMD are still unclear. We investigated in vivo force generation and ex vivo Ca2+‐activated force generation, Ca2+ sensitivity, and myofiber Ca2+ handling systems (SR and t‐tubules) in human biceps brachii before and 2, 48, and 96 h after eccentrically muscle‐damaging contractions and in non‐exercised control arm. The force‐generating capacity declined by 50 ± 13% 3 h after exercise and was still not recovered after 96 h. The force‐Ca relationship of skinned myofibers revealed an impaired maximal Ca2+‐activated force in MHC I‐fibers, but not MHC II‐fibers 48 h after exercise. Further, Ca2+ sensitivity was increased in MHC II‐fibers, which was reversed after incubation with a strong reductant. There was a biphasic increase in SERCA sulfonylation, and a parallel reduction in the SR Ca2+ uptake rate, with no effects on SR vesicle leak or SR vesicle Ca2+ release rate. T‐tubules showed a progressive increase in the density of longitudinal tubules by 96 h after exercise. In conclusion, MHC II‐fiber Ca2+ sensitivity was increased 48 h after exercise, attributed to changes in the REDOX status. 96 h after exercise SR vesicle Ca2+ uptake was impaired, and an increased number of longitudinal tubules were observed. These alterations may contribute to the impaired force generation evident at the late stage of recovery.
Establishment of gender– and age–related reference intervals for serum uric acid in adults based on big data from Zhejiang Province in China
Authors: Chen Dandan , Zhou Yunxian , Fan Lina , Yang Zheng , Yang Dagan
Published: February 2025

Objectives

This study utilized large-scale health examination data to explore gender– and age–specific reference intervals (RIs) for serum uric acid (UA) using indirect methods and assessed the consistency of different approaches.

Methods

UA data were collected from a hospital in Zhejiang Province, China. The test set covered January 2019 to December 2023, with a validation set from January to June 2024. Various methods – EP28 nonparametric (EP28-NP), parametric (EP28-P), TMC, refineR, and Kosmic – were used to establish gender– and age–specific RIs. Continuous age-based RIs were derived using the Generalized Additive Model for Location Scale and Shape (GAMLSS). Validation rates were calculated for each method using the validation set.

Results

Using EP28-NP as the benchmark, other methods showed similar UA RIs (bias ratios ≤0.375, except for one group), with Kosmic, refineR, and TMC yielding slightly higher values than EP28-NP and EP28-P. For males, UA RIs varied by age: 19–42 years (256–537 μmol/L), 43–66 years (235–513 μmol/L) and ≥67 years (214–515 μmol/L), with validation rates ranging from 94.05 to 96.50 %. Male continuous RIs declined from ages 20–79 and then gradually increased after age 80. For females, UA RIs were age-dependent: 19–48 years (169–374 μmol/L), 49–74 years (178–405 μmol/L), and ≥75 years (186–470 μmol/L), with validation rates ranging from 92.70 to 96.80 %. Female continuous RIs decreased from ages 20–48, then increased significantly from age 49 onward.

Conclusions

Three indirect methods and two EP28 methods demonstrated good consistency in establishing UA RIs. Males had higher RIs than females, and RIs showed a non-linear correlation with age.
Language ideology as fake news
Authors: Ajšić Adnan
Published: February 2025

Fake news has a long history despite coming to the fore of academic debates only recently. The current fake news epidemic is related to the rise in right-wing populism globally, while social media has been central to the rapid spread of misinformation and the corrosive influence of right-wing populist discourses thriving on online conspiracy theories and disinformation campaigns. But does this trend have identifiable historical antecedents? I argue that 1980s and 1990s Serbian nationalist propaganda, especially its deployment of pseudoscientific discourses on language with their underlying language ideologies, may be a direct antecedent and an instructive case study for our understanding of the current wave. The discussion is based upon a corpus of Serbian news published between 2003 and 2008, and the application of advanced methods such as exploratory factor analysis and topic modeling. The findings show that the Central South Slavic language conflict has been characterized by pseudoscientific argumentation deployed as (fake) news. I suggest that there is a link between Central South Slavic ethnolinguistic contestation and contemporary Western far right discourses, contending that pseudoscientific argumentation is a major type of fake news in the service of illiberal causes and should be a central element in analyses of the phenomenon.
Critical review on the derivative of graphene with binary metal oxide-based nanocomposites for high-performance supercapacitor electrodes
Authors: Kandwal Kenya , Jain Alok , Kumar Rajeev , Sharma Shubham , Bains Pardeep Singh , Sharma Ashish , Joshi Sanjeev Kumar , Kozak Dražan , Abbas Mohamed , Lozanovic Jasmina
Published: February 2025

Supercapacitors, owing to their high power density and rapid charge–discharge capabilities, have gained significant attention as energy storage devices in various applications. In the context of electrochemical supercapacitors, this article provides a comprehensive review of the production and electrochemical performance of binary metal oxide (BMO) and reduced graphene oxide (rGO) composite materials. The synthesis processes and synergistic benefits of BMO–rGO composites, with an emphasis on how they perform better than separate parts in terms of specific capacitance and cycle stability, are discussed. The potential of BMO–rGO composites as high-performance electrode materials for supercapacitors is highlighted in this research. In the context of electrochemical supercapacitors, this work provides a comprehensive review of the production and electrochemical performance of binary transition metal oxide (TMO) and rGO composite materials. Composite materials with enhanced electrochemical characteristics that are appropriate for supercapacitor applications are the primary novelty, which is the synergistic combination of rGO with a variety of TMOs. Compared to individual TMOs or other carbonaceous materials, these composites demonstrate enhanced specific capacitance, energy density, power density, cyclic stability, and rate capability. The synthesis processes and synergistic benefits of BMO–rGO composites are discussed, with an emphasis on their superior performance in specific capacitance and cycle stability compared to individual components. This research highlights the potential of BMO–rGO composites as high-performance electrode materials for supercapacitors, showcasing their enhanced specific capacitance, improved charge storage capacity, increased power density, excellent cycling stability, and overall durability even after numerous charge–discharge cycles.
Polycarbinol-siloxane surfactants: synthesis, characterization, fire suppression evaluation and foaming-defoaming properties
Authors: Snow Arthur W. , Ananth Ramagopal
Published: February 2025

A series of polycarbinol-siloxane surfactants with variations of two to six hydroxyl groups in the head structure and tri- and tetrasiloxane tail structures is synthesized, characterized and tested for foaming ability and fire suppression. The synthesis is practical, involving two steps, and produces products in high yield with good purity. The trisiloxane surfactants with 5 or 6 hydroxyl groups have sufficient water solubility, critical micelle concentrations, and display foaming ability levels to be effective in fire suppression testing. The tetrasiloxane surfactant with six hydroxyl groups was less soluble by a factor of 10 and did not exhibit sufficient foaming for effective fire suppression.