bluuebunny/crossref_metadata_2025 huggingface dataset:
New Aspects in the Mechanism of Action of 3-hydroxy-3-methylglutaryl- COA Reductase (HMG-CoA reductase): Cyclic Lactones - Potential Inhibitors of the Enzyme (Review)
Authors: Boyarintsev D.I. , Kuzminov I.V. , Orlova M.V.
Published: July 2024

:

The aim is to systematize data from literature sources on the study of changes in the activity
of HMGR enzymes and lipid metabolism under the influence of cyclic lactones, identify among
them new potential inhibitors of HMGR and formulate hypotheses about the details of the mechanism
of action of the enzyme in relation to the product - mevalonolactone.
Stress Management Therapy through Adaptogens and Rasayanas in
Ayurveda: A Comprehensive Review
Authors: Najar Imtiyaz Ahmed , Pamu Sagar , Patyar Sazal , Madhira Geetha , Sharma Akhil , Devi Sushma , Lamba Khushi , Arora Poonam , Kumar Manish
Published: July 2024

This review focuses on how modern stress management incorporates Ayurvedic concepts,
particularly rasayanas and adaptogens. In order to promote complete well-being, Ayurveda’s age-old
holistic therapeutic method places an emphasis on mental, physical, and spiritual harmony. An imbalance of the basic bio-elements (doshas) that impacts one’s bodily and mental well-being is referred
to as stress. Important components of stress treatment include rasayanas, which are reviving formulations, and adaptogens, which are herbs that boost stress tolerance. Liquorice root, Tulsi, Brahmi,
Shatavari, Ashwagandha, and rasayanas like Amla and Chyawanprash constitute crucial adaptogens.
The hypothalamic-pituitary-adrenal axis (a major regulator of stress response), antioxidant pathways,
inflammation, and immune-mediated regulation are critically involved in the pathogenesis of stress,
and all are immediately impacted by new mechanistic discoveries that lead to better alleviation of
stress culminating in the initiation of a myriad of protective responses such as hepatoprotection, renoprotection, cardioprotection, and neuroprotection. Expert guidance is required to address safety issues, dosing recommendations, and specific considerations during pregnancy and nursing regarding
the clinical use of these adaptogens and rasayanas. Integrating Ayurvedic concepts in modern
healthcare meets problems such as standardization and quality control. However, Ayurveda’s holistic
approach aligns with preventive and personalized healthcare trends. Collaborative efforts between
Ayurvedic and conventional practitioners could lead to synergistic benefits. In this purview, research
directions include identifying novel adaptogens, exploring mechanisms of action, and studying longterm effects and sustainability. Future studies must adopt evidence-based practices and consider
Ayurveda’s individualized therapy approach. Integrating adaptogens and rasayanas in mainstream
healthcare offers promising holistic strategies for stress management, aligning with the growing demand for natural and comprehensive wellness solutions.
Beta-site APP-cleaving Enzyme-1 Inhibitory Role of Natural Flavonoids in the Treatment of Alzheimer's Disease
Authors: Singh Sandeep , Kushwaha Virendra , Sisodia Shriram , Kumar Shivendra , Sahu Kantrol Kumar
Published: July 2024

Alzheimer's Disease (AD) is a devastating neurological condition characterized by a
progressive decline in cognitive function, including memory loss, reasoning difficulties, and
disorientation. Its hallmark features include the formation of neurofibrillary tangles and neuritic
plaques in the brain, disrupting normal neuronal function. Neurofibrillary tangles, composed of
phosphorylated tau protein and neuritic plaques, containing amyloid-β protein (Aβ) aggregates,
contribute to the degenerative process. The discovery of the beta-site amyloid precursor protein
cleaving enzyme 1 (BACE1) in 1999 revolutionized our understanding of AD pathogenesis.
BACE1 plays a crucial role in the production of Aβ, the toxic protein implicated in AD progression.
Elevated levels of BACE1 have been observed in AD brains and bodily fluids, underscoring
its significance in disease onset and progression. Despite setbacks in clinical trials of
BACE1 inhibitors due to efficacy and safety concerns, targeting BACE1 remains a promising
therapeutic strategy for early-stage AD. Natural flavonoids have emerged as potential BACE1
inhibitors, demonstrating the ability to reduce Aβ production in neuronal cells and inhibit
BACE1 activity. In our review, we delve into the pathophysiology of AD, highlighting the central
role of BACE1 in Aβ production and disease progression. We explore the therapeutic potential
of BACE1 inhibitors, including natural flavonoids, in controlling AD symptoms. Additionally,
we provide insights into ongoing clinical trials and available patents in this field, shedding
light on future directions for AD treatment research.
Gastric Cancer - Just One Bite: Is it Enough? Comparing the Use of Seven
Biopsies with that of Only One Endoscopic Biopsy to Diagnose Advanced
Gastric Cancer
Authors: Pelosi Alexandre Dias , Luna Patricia Abrantes , de Souza e Mello Gustavo Francisco , de Oliveira Ivanir Martins , Ferreira Maria Aparecida , Thuler Luiz Claudio Santos , Lewandrowski Kai-Uwe , Fiorelli Rossano Kepler Alvim
Published: July 2024

Background:

Gastric cancer is prevalent in the Brazilian population, with diagnosis
largely reliant on endoscopic biopsies. Current guidelines recommend a minimum of seven endoscopic biopsies. However, advances in high-definition imaging, chromoendoscopy technologies (such as narrow-band imaging [NBI]), and histopathological techniques suggest that fewer
biopsies might suffice. Validating this hypothesis could reduce the duration of examinations,
lessen the burden on pathologists, and minimize risks associated with multiple biopsies.

Methods:

This prospective study evaluated the efficacy of various biopsy strategies in diagnosing gastric lesions. A total of 106 lesions from 104 patients were examined over 14 months. The
study compared the diagnostic yield of the conventional seven biopsies (considered the gold
standard) with a single white-light biopsy, one NBI-guided biopsy, and a combination of both
white-light and NBI-guided biopsies.

Results:

When compared to the gold standard of seven biopsies, the single white-light biopsy
demonstrated a sensitivity of 90.1% (range 82.5-95.6%) and a specificity of 100% (range 47.8-
100%). The NBI-guided biopsy yielded a sensitivity of 83.2% (range 74.4-89.9%) and a specificity of 100% (range 47.8-100%). Combining both biopsy techniques achieved a sensitivity of
96.1% and a specificity of 100%.

Conclusions:

A single white-light biopsy was found to be nearly equivalent to the gold standard
of seven biopsies, using a 10% difference as the noninferiority criterion. Performing two biopsies-one conventional and one NBI-guided-provided even greater accuracy, closely approximating that of the gold standard.
WAWASAN KEBANGSAAN DALAM PEMBANGUNAN KARAKTER GENERASI MUDA
Authors: Shabrilia Farikha Fitria ,   Universitas Airlangga, Pandin Moses Glorino Rumambo ,   Universitas Airlangga
Published: July 2024

WAWASAN KEBANGSAAN DALAM PEMBANGUNAN KARAKTER GENERASI MUDA
Precálculo. Con aplicaciones a las funciones
Authors: Ocaña Gómez Adelina ,   Universidad de Bogotá Jorge Tadeo Lozano, Perez Ruiz Mario
Published: July 2024

En el libro Precálculo con aplicaciones a las funciones se presenta el concepto de función y sus características: dominio, rango, cortes con los ejes, intervalos de monotonía, intervalos en los que la función es positiva o negativa, entre otras. Al incluir las trasformaciones y operaciones entre funciones se amplían los puntos desde los cuales es posible acercarse y comprender cualquier tipo de función. Las funciones lineales, cuadráticas, polinomiales, racionales, exponenciales y logarítmicas, a las cuales se les dedica buena parte del libro, se estudian por medio de los aspectos generales y particulares de cada función, y son presentados en un lenguaje sencillo y claro con ejemplos y problemas ampliamente desarrollados. En cada sección se incluyen ejercicios y problemas, en diversos contextos, que permiten afianzar los conceptos tratados.
Evidence-Based Practices in an Early Intervention service in Spain: the voice of families
Authors: Della Barba Patricia Carla de Souza , Cañadas Perez Margarita
Published: July 2024

This study was carried out at the Centro de Atención Temprana y Escuela Infantil L'Alqueria, Universidad Catolica de Valencia, as part of the Observatorio Internacional de Atención Temprana y Desarrollo Infantil (International Observatory of Early Childhood Intervention and Development), and its aim was to identify the families' perceptions and role in the intervention process, the child's development, the quality of family life and their own empowerment.  It involved the participation of a final sample of five families accompanied by four professionals for 11 months. The source of data used was audio recordings of the families, transcribed by the researcher, and the application of instruments before and after six months of intervention, which were analysed qualitatively. The analysis focused on the families' perceptions of the intervention process, child development, family quality of life and empowerment. The results indicate that families perceive the intervention as support, feel empowered to act in the contexts, learn strategies for child development and identify learning opportunities in their routines. Communication is valued, showing that families have a voice in the intervention process. The responses to the instruments indicate that families have a positive view of their children's development and perceive an improvement in the quality of family life. These findings point to the importance of evidence-based practices in Early Intervention.
Validación del concepto de eficacia colectiva. Un estudio en barrios latinoamericanos
Authors: Manzano-Chávez Liliana , Jiménez-García Williams , Vega-Torrejon Fernando
Published: July 2024

El concepto de eficacia colectiva vinculado a la investigación de delitos en barrios surgió en Estados Unidos en los años noventa y pronto fue reconocida como una teoría validada. Sin embargo, su aplicación en América Latina ha evidenciado inconsistencias. A partir de datos de Bogotá, Lima y Santiago, este artículo evalúa la estructura factorial del concepto y su aplicabilidad al estudio de delitos violentos en barrios latinoamericanos. Para ello se estimaron modelos factoriales, invarianza y comparación de medias. Los hallazgos revelan que la eficacia colectiva se compone de tres dimensiones (confianza, cohesión y control social informal), y para cada dimensión se observan medias diferenciadas según experiencia de victimización violenta y ciudad. Así, la composición multidimensional de la eficacia colectiva ofrece una perspectiva enriquecedora para profundizar en los desafíos de la prevención del delito en entornos criminológicos complejos del Sur global.
Sociología del crimen en América Latina
Authors: Alvarado-Mendoza Arturo , Díaz-Román Mario Pavel , Fernández-Osorio Andres Eduardo
Published: July 2024

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Perfil de actividad física juvenil en escolares en confinamiento, Zipaquirá, Colombia
Authors: Herrera-Cubillos Edgar , Zapata-Torres Diana Marcela , Sanjuanelo-Corredor Danny Wilson
Published: July 2024

este capítulo examina el perfil de actividad física juvenil de adolescentes escolares, para el fomento de estrategias de promoción de la salud en confinamiento. Método: estudio descriptivo, enfoque cuantitativo, transversal. Variables primarias nivel de actividad física moderado y vigoroso: durante jornada escolar, fuera de la jornada escolar, en tiempo libre, fin de semana y comportamiento sedentario, incluyendo variables secundarias edad, sexo, grado. En los tres grupos etarios se reporta un bajo nivel de actividad física: 12-13 años, 5,71 %; 14-15 años, 19,51 %, y 16 -17 años, 22,31 %, por debajo de la recomendación OMS. Se concluye que hay una disminución en la práctica de actividad física moderada a vigorosa (MVPA) en adolescentes a medida que se incrementa la edad.
Ejército Nacional de Colombia: capacitación impartida a la población rural, 1953-1966
Authors: Velásquez-Cuervo Bibiana , Duque-López José Octavio
Published: July 2024

Este capítulo describe los programas, avances y vacíos en la educación de la población rural que, en el periodo 1953-1966 fueron suplidos por el Ejército Nacional de Colombia (EJC). Por lo tanto, se señalan los elementos sociales, económicos, políticos y educacionales del país de aquella época, en pro de conocer por qué el EJC, mediante el cumplimiento de la intención del Gobierno de turno, y de acuerdo con las consideraciones generales de orden público, realizó labores de acercamiento con los campesinos. Se subraya que, dentro de estas labores, estuvo la educación difundida mediante las acciones cívico-militares que se encontraban en los planes militares desarrollados en este periodo colombiano.
The new service development process of green FinTech innovation: A multi-case study
Authors: Thanapongporn Ajaree ,   Technopreneurship and Innovation Management Program, Chulalongkorn University, Bangkok, Thailand, Saengchote Kanis , Gowanit Chupun ,   Department of Banking and Finance, Chulalongkorn University, Bangkok, Thailand,   Technopreneurship and Innovation Management Program, Chulalongkorn University, Bangkok, Thailand
Published: July 2024

In light of increasing global challenges like climate change, carbon neutrality, and biodiversity loss, the need for sustainable solutions is essential. Green FinTech innovation, which combines financial resources, services, and technologies, has become a significant area of focus for addressing these issues. However, despite growing interest from various stakeholders, progress towards sustainable development remains slow due to fragmented academic knowledge. This study aims to bridge this gap by offering practical guidelines for those involved in green FinTech innovation. By examining the new service development process, including both the front-end and back-end stages, the study will identify key influencers such as customers, organizations, and partners. Semi-structured interviews will be conducted with three green FinTech case studies in Thailand, specifically focusing on rental electric bike services, energy trading systems, and solar rooftop platforms. The research will investigate the concepts, methods, and critical success factors that drive the innovation processes of these projects through a comparative multi-case study. The findings will reveal different paths for B2B and B2C green FinTech innovation, emphasizing the importance of external factors. Successful innovation requires a thorough understanding of customer behavior, beyond just pro-environmental tendencies. These insights aim to accelerate green FinTech innovation in emerging economies and underscore the need for further quantitative research to validate these findings. This research will provide valuable insights for policymakers, financial institutions, and innovators, supporting the advancement of sustainable development through green FinTech solutions.
Modelo de evaluación de contabilidad de gestión para empresas de servicios
Authors: Moyano Yerovi Sandra , Pérez Barral Osmany
Published: July 2024

Los constantes cambios en los sistemas de evaluación requieren que las empresas de servicios adopten nuevas formas de procesar la información financiera, con lo cual, el estudio centra su objetivo en proponer un modelo de evaluación de contabilidad de gestión para la toma de decisiones, con el propósito de evaluar diferentes procesos de gestión aplicados y lograr resultados en las empresas de servicios. La metodología empleada en esta investigación es de tipo descriptiva-explicativa, dado que, se detallan los componentes de mayor relevancia dentro de la información financiera de las empresas de servicios, siendo necesario aplicar el método inductivo - deductivo, partiendo de la revisión de los procesos contables para llegar a conclusiones generales relativas a la información financieras y a la forma de cómo esta es procesada por los colaboradores. El resultado muestra la necesidad de alcanzar flexibilidad sobre el manejo de la información financiera para responder a las necesidades en los diferentes niveles directivos de la organización, con direccionamiento hacia el cumplimiento de objetivos a través de una eficiente capacidad organizacional y la oferta de servicios de alta calidad.
Estudio del proceso metodológico del examen complexivo: Lecciones aprendidas en la Facultad de Ciencias Agrícolas de la Universidad Central del Ecuador
Authors: Vivas Vivas Ramiro , Borja Vivero Juan , Molina Velásquez Edison , Aguirre Flores Alejandro
Published: July 2024

La universidad ecuatoriana requiere que sus estudiantes completen un trabajo académico como parte de los requisitos para obtener su titulación. Sin embargo, a partir de la publicación del Reglamento de Régimen Académico por el Consejo de Educación Superior de Ecuador (CES), se ha añadido el examen complexivo a estos requisitos. Si bien hay estudios preliminares, en el área de las ciencias agrícolas en el Ecuador, las indagaciones científicas sobre la aplicación de esta modalidad son limitadas. Esta investigación tiene como objetivo aportar los primeros resultados y lecciones aprendidas en la aplicación de este examen a estudiantes de Ingeniería Agronómica en la Facultad de Ciencias Agrícolas de la Universidad Central del Ecuador (UCE). No obstante, la información actual resulta insuficiente para llegar a conclusiones definitivas. El alcance de la investigación fue de tipo exploratorio y descriptivo. La población inicial constó de 19 estudiantes, de los cuales 7 no completaron los requisitos para ser declarados aptos. La muestra final se compuso de 12 estudiantes, equitativamente distribuidos entre hombres y mujeres. El acompañamiento en el componente teórico involucró a 6 docentes; mientras que, en el componente práctico participaron 20 docentes y 6 técnicos docentes. Los datos obtenidos cumplieron con los supuestos de normalidad y se ajustaron a una distribución de tipo paramétrica. No se encontraron diferencias estadísticas en la media del rendimiento general entre hombres y mujeres. En el componente teórico, se observó una media más alta en los hombres, y en cambio, el componente práctico mostró un rendimiento superior en las mujeres.
Leadership for AI Transformation in Health Care Organization: Scoping Review
Authors: Sriharan Abi , Sekercioglu Nigar , Mitchell Cheryl , Senkaiahliyan Senthujan , Hertelendy Attila , Porter Tracy , Banaszak-Holl Jane
Published: July 2024

Background

The leaders of health care organizations are grappling with rising expenses and surging demands for health services. In response, they are increasingly embracing artificial intelligence (AI) technologies to improve patient care delivery, alleviate operational burdens, and efficiently improve health care safety and quality.

Objective

In this paper, we map the current literature and synthesize insights on the role of leadership in driving AI transformation within health care organizations.

Methods

We conducted a comprehensive search across several databases, including MEDLINE (via Ovid), PsycINFO (via Ovid), CINAHL (via EBSCO), Business Source Premier (via EBSCO), and Canadian Business & Current Affairs (via ProQuest), spanning articles published from 2015 to June 2023 discussing AI transformation within the health care sector. Specifically, we focused on empirical studies with a particular emphasis on leadership. We used an inductive, thematic analysis approach to qualitatively map the evidence. The findings were reported in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews) guidelines.

Results

A comprehensive review of 2813 unique abstracts led to the retrieval of 97 full-text articles, with 22 included for detailed assessment. Our literature mapping reveals that successful AI integration within healthcare organizations requires leadership engagement across technological, strategic, operational, and organizational domains. Leaders must demonstrate a blend of technical expertise, adaptive strategies, and strong interpersonal skills to navigate the dynamic healthcare landscape shaped by complex regulatory, technological, and organizational factors.

Conclusions

In conclusion, leading AI transformation in healthcare requires a multidimensional approach, with leadership across technological, strategic, operational, and organizational domains. Organizations should implement a comprehensive leadership development strategy, including targeted training and cross-functional collaboration, to equip leaders with the skills needed for AI integration. Additionally, when upskilling or recruiting AI talent, priority should be given to individuals with a strong mix of technical expertise, adaptive capacity, and interpersonal acumen, enabling them to navigate the unique complexities of the healthcare environment.
Regulatory Frameworks for AI-Enabled Medical Device Software in China: Comparative Analysis and Review of Implications for Global Manufacturer (Preprint)
Authors: Han Yu , Ceross Aaron , Bergmann Jeroen
Published: July 2024

UNSTRUCTURED

The China State Council released the new generation artificial intelligence (AI) development plan, outlining China's ambitious aspiration to assume global leadership in AI by the year 2030. This initiative underscores the extensive applicability of AI across diverse domains, including manufacturing, law, and medicine. With China establishing itself as a major producer and consumer of medical devices, there has been a notable increase in software registrations. This study aims to study the proliferation of health care–related software development within China. This work presents an overview of the Chinese regulatory framework for medical device software. The analysis covers both software as a medical device and software in a medical device. A comparative approach is employed to examine the regulations governing medical devices with AI and machine learning in China, the United States, and Europe. The study highlights the significant proliferation of health care–related software development within China, which has led to an increased demand for comprehensive regulatory guidance, particularly for international manufacturers. The comparative analysis reveals distinct regulatory frameworks and requirements across the three regions. This paper provides a useful outline of the current state of regulations for medical software in China and identifies the regulatory challenges posed by the rapid advancements in AI and machine learning technologies. Understanding these challenges is crucial for international manufacturers and stakeholders aiming to navigate the complex regulatory landscape.
Effectiveness of eHealth Interventions in Improving Medication Adherence Among Patients With Cardiovascular Disease: Systematic Review and Meta-Analysis (Preprint)
Authors: Miao Yiqun , Luo Yuan , Zhao Yuhan , Liu Mingxuan , Wang Huiying , Wu Ying
Published: July 2024

BACKGROUND

Nonadherence to medication among patients with cardiovascular diseases undermines the desired therapeutic outcomes. eHealth interventions emerge as promising strategies to effectively tackle this issue.

OBJECTIVE

The aim of this study was to conduct a network meta-analysis (NMA) to compare and rank the efficacy of various eHealth interventions in improving medication adherence among patients with cardiovascular diseases (CVDs).

METHODS

A systematic search strategy was conducted in PubMed, Embase, Web of Science, Cochrane, China National Knowledge Infrastructure Library (CNKI), China Science and Technology Journal Database (Weipu), and WanFang databases to search for randomized controlled trials (RCTs) published from their inception on January 15, 2024. We carried out a frequentist NMA to compare the efficacy of various eHealth interventions. The quality of the literature was assessed using the risk of bias tool from the Cochrane Handbook (version 2.0), and extracted data were analyzed using Stata16.0 (StataCorp LLC) and RevMan5.4 software (Cochrane Collaboration). The certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach.

RESULTS

A total of 21 RCTs involving 3904 patients were enrolled. The NMA revealed that combined interventions (standardized mean difference [SMD] 0.89, 95% CI 0.22-1.57), telephone support (SMD 0.68, 95% CI 0.02-1.33), telemonitoring interventions (SMD 0.70, 95% CI 0.02-1.39), and mobile phone app interventions (SMD 0.65, 95% CI 0.01-1.30) were statistically superior to usual care. However, SMS compared to usual care showed no statistical difference. Notably, the combined intervention, with a surface under the cumulative ranking curve of 79.3%, appeared to be the most effective option for patients with CVDs. Regarding systolic blood pressure and diastolic blood pressure outcomes, the combined intervention also had the highest probability of being the best intervention.

CONCLUSIONS

The research indicates that the combined intervention (SMS text messaging and telephone support) has the greatest likelihood of being the most effective eHealth intervention to improve medication adherence in patients with CVDs, followed by telemonitoring, telephone support, and app interventions. The results of these network meta-analyses can provide crucial evidence-based support for health care providers to enhance patients’ medication adherence. Given the differences in the design and implementation of eHealth interventions, further large-scale, well-designed multicenter trials are needed.

CLINICALTRIAL

INPLASY 2023120063; https://inplasy.com/inplasy-2023-12-0063/
Water Content and Pb Concentrations in the Bottom Sediments Of The Gdansk Deep (South-Eastern Baltic Sea) According to the Portable X-Ray Fluorescence Analyzer Olympus Vanta C
Authors: Laskina D. , Dorokhova E. , Koroleva Yu.
Published: July 2024

This work describes a method for determining the water content in sediments from the Gulf of Gdansk of the Baltic Sea, which is based on the analysis of spectral data obtained using the portable X-ray fluorescence analyzer (XRF) Olympus Vanta C. The water content calculated from the XRF spectral data showed a high correlation ( = 0.95) with those measured using the conventional method of drying to constant mass. This allows the conversion between the results obtained using the portable XRF analyzer on bulk sediments to those obtained on dried sediments. Comparison of the converted data from the portable analyzer with the results of element composition analysis performed on dried homogenized samples using the wavelength-dispersive XRF analyzer Spectroscan-Max-G and atomic absorption spectrophotometer Varian AA240FS showed high correlation coefficients for Mn, Ca, K, Zn, Pb, As and low coefficients for Fe, Co, Ti, Ni, Cu and Sr. The results of the analysis using the portable XRF spectrometer, converted to dry weight of the sediment, were used to study the distribution of Pb concentrations in the sediments of the Gulf of Gdansk. An increase in Pb content up to 60 ppm was observed in the upper part of sediment cover. This increase is likely associated with the intensification of anthropogenic activities in AD 1 and AD 1200. Maximum lead concentrations up to 124 ppm were found in near-surface sediments, likely related to the period of industrialization in the 1970s.
Determinants on green purchasing behavior of generation Y: Empirical evidence in Can Tho city
Authors: Ngo My Tran , Bui Thi Kim Thanh , Tran Buu Hau
Published: July 2024

This study aims to analyze the determinants of green purchasing behavior of Generation Y in Can Tho city based on the survey data from 180 consumers. The results estimated by PLS - SEM show that concern for the environment has the highest impact on green purchasing intention, followed by green price sensitivity and perceived green behavior control. Besides, the evidence indicates that green purchasing intention has a positive effect on the green purchasing behavior of millennials. Based on the research results, several managerial implications have been proposed for businesses in the industry. These include the need to expand selling locations and distribution channels to increase the convenience of finding green products; organizing environmental awareness campaigns in collaboration with government agencies; developing product pricing strategies that reflect the product's value and consumer benefits; and enhancing consumer intentions by implementing communication campaigns that highlight the information and benefits of green products.
Evaluating the performance of Random Forest, Decision Tree, Support Vector Regression and Gradient Boosting for streamflow prediction
Authors: Idemudia Osahon , Ehiorobo Jacob Odeh , Izinyon Christopher Osadolor , Ilaboya Idowu
Published: July 2024

This study utilized a range of machine learning algorithms to predict the hourly streamflow in the Ikpoba River. Data gathering relied on a Hydromet System installed along the river, collecting hourly measurements of gage height, ambient temperature, and atmospheric pressure. To convert the gage height to streamflow data, historical gage and streamflow data covering the period from 2015 to 2020 were extracted from the Ikpoba River rating curve and were analyzed using curve fitting techniques to establish the precise relationship between streamflow and gage height. Various goodness-of-fit measures, such as adjusted R-squared value, standard error of estimate, and coefficient of determination, were utilized to identify the best-fit relationship. The estimated streamflow data were subsequently validated using the Soil and Water Assessment Tool, incorporating the digital elevation model of the study area, along with other input parameters like soil, slope, daily maximum precipitation, and daily maximum temperature. Validation results were illustrated using regression plots generated in Microsoft Excel. From the machine learning results, random forest algorithm outperformed other methods in predicting streamflow, with a mean square error of 0.02 and a coefficient of determination of 0.98. Conversely, decision trees showed superior accuracy in predicting individual data points, with the lowest root-mean-square error of 0.02.
Research on the Motivation and Effect of "Deceptive" Share Repurchase—Take Orient Group Incorporationas an Example
Authors: Wang Dianjie
Published: July 2024

With the continuous improvement of China's share repurchase system, the policy optimization actively promotes the application of share repurchase in the capital market, and makes it become a common way for listed companies to manage market value. However, the problems presented by listed companies in the implementation of share repurchase plans have gradually been exposed, especially the frequent occurrence of "deceptive" repurchase, which has become the focus of the market. In order to solve this problem, China has issued detailed rules for the implementation of share repurchase, clearly emphasizing the prevention of "deceptive" repurchase, aiming at guiding listed companies to operate in compliance. However, due to the low cost of violation, most listings still fail to comply with the standards and continue to appear "deceptive" buyback behavior. Therefore, by analyzing the motivation of listed companies to implement "deceptive" share repurchase behavior and the economic consequences, this paper provides a warning for investors, urges listed companies to self-examine the share repurchase plan, and puts forward regulatory suggestions for the regulatory authorities to be optimized.
A study of the Performance of Haier Smart under Digital Transformation
Authors: Zhang Yuchao
Published: July 2024

In recent years, the digital boom has continued to hit, and global scientific and technological innovation has been unprecedentedly intensive and active. On the cusp of this 5G trend, emerging technologies such as artificial intelligence, cloud sharing, and big data are emerging in an endless stream, constantly impacting traditional technologies and the real economy. The fourth industrial revolution has quietly penetrated into every corner of society. Both people's lives and the economic environment have been unprecedentedly affected. As an important pillar industry in the national economic construction, how to meet the digital transformation, seize the opportunity of digital transformation, enhance product value, and create new quality productivity has become particularly important. This paper takes digital transformation as the starting point, explores the motivation and path of Haier's digital transformation in the past ten years, and evaluates its performance. The study found that Haier Smart Home's digital transformation has improved the long-term performance of enterprises; the first enlightenment is to accelerate the transformation and upgrading and improve the degree of digital attention ; second, adhere to innovation-driven, enhance digital R & D sales; third, create a digital platform to enhance the user's personalized experience. It is expected that the research in this paper can provide some reference for the digital transformation of other household appliance enterprises and bring some help to the digitization of China's household appliance manufacturing industry.
IPO Pricing Theory and Mechanism under the Registration System
Authors: Yin Wenjie
Published: July 2024

When a firm makes an initial public offering (IPO) and qualifies for listing, it negotiates and determines a price with its underwriters for the public sale of its shares to specific or non-specific investors. This paper elaborates the theory of IPO price suppression through literature review and analysis, and also summarizes the IPO pricing mechanism. It helps to provide guidelines for the study of IPO pricing in China under the registration system environment and assists the regulators to further improve the relevant regulations.
Community Administrativeisation and Governance Measures - A Case Study of Community S in Chengdu City
Authors: Deng Yuling
Published: July 2024

Since the reform of the "unit system", the problems exposed in the operation of community neighbourhood committees have led to endless debate in the academic community about the need for "administrativeisation". The theoretical basis for the "de-administration" of community neighbourhood committees comes from the relevant provisions of the Constitution and the law, while the theoretical basis for "administrativeisation" comes from the real problems that exist in practice, which is the gap between what should be the case and what is the case for community neighbourhood committees. Based on a sample analysis of Community S in Chengdu City, this paper synthesises the actual situation of community neighbourhood committees across the country, and puts forward some thoughts on the governance of community neighbourhood committees.
ROLE OF POLIDOCANOL IN PERCUTANEOUS SCLEROTHERAPY IN TREATMENT OF ANEURYSMAL BONE CYST – A SINGLE-CENTER STUDY
Authors: PAVAN KUMAR BABU  , S SUJIN , AJAY RAIDU G  , UMA SHANKAR
Published: July 2024

Objectives: To study the clinical and radiological outcomes in patients treated with 3% polidocanol as a sclerosing agent in percutaneous sclerotherapy for aneurysmal bone cyst (ABC).
Methods: This is a single-centered retrospective study conducted in the Department of Orthopaedics at Kurnool Medical College with 23 patients from 2018 to 2021 over 3 years, where 3% polidocanol was used as a sclerosing agent in percutaneous sclerotherapy as a treatment option for ABC. Postoperatively, patients are evaluated based on clinical and radiological examinations.
Results: Clinically, patients were compared to their own Visual Analog Score (VAS) at the time of healing to the VAS score during their first visit. The mean VAS during the first visit was 7.6. At the time of healing, there were only two patients who scored a score of 1 on the VAS. Radiologically, plain radiographs were observed for ossification. 20 (86.9%) patients achieved complete ossification, 2 (8.69%) patients could achieve partial ossification.
Conclusion: With this study, we would like to present that percutaneous sclerotherapy with 3% polidocanol is effective both clinically and radiologically in the treatment of ABCs. Our institution has adopted sclerotherapy as part of salvage therapy and as the first line of treatment in treating ABC tumors.
EFFECT OF INTRAVENOUS LIGNOCAINE ON HEMODYNAMIC VARIABLES DURING INTRAOPERATIVE AND POST-OPERATIVE PERIOD
Authors: KHANDEKAR SHEETAL , TITLER SANJIV , SHYAMBARAN  , DR RAKESH , SINGH RAVINDRA
Published: July 2024

Objectives: The objective of this study was to assess the efficacy of intravenous lignocaine on hemodynamic variables during intraoperative and post-operative periods and in relieving post-operative pain in major abdominal surgery.
Methods: To investigate the effects of lidocaine, we designed a double-blind study. We enrolled 100 patients of ASA Grade I or II slated for major abdominal procedures. Each participant received either lidocaine or a saline placebo intravenously. After surgery, we monitored their pain levels, vital signs, and any potential side effects.
Results: Our study revealed clear differences in heart rate, blood pressure (both systolic and diastolic), and overall arterial pressure between the lidocaine and placebo groups. Notably, the lidocaine group experienced fewer side effects, such as nausea, vomiting, headache, and shivering, compared to the control group.
Conclusion: Intravenous lidocaine reduces intraoperative and post-operative pulse rate and blood pressure in major abdominal surgery. It delays analgesic needs and lowers the incidence of nausea, vomiting, chills, and headache compared to controls.
POST-OPERATIVE URINARY RETENTION AFTER SPINAL ANESTHESIA IN HERNIA SURGERY: A PROSPECTIVE, COMPARATIVE DOUBLE-BLIND STUDY BETWEEN ROPIVACAINE HEAVY 0.75% AND BUPIVACAINE HEAVY 0.5%
Authors: HETAL KANABAR  , DIPTI DESAI  , DINESH C BABARIYA  , LAXMI YADAV  , KANVEE M VANIA
Published: July 2024

Objective: The objective of this study was to evaluate and compare the effect of spinal anesthesia (SA) with bupivacaine and ropivacaine on recovery of bladder function and time of ambulation in healthy men who were scheduled for hernia surgery.
Methods: In this double-blind study, 60 patients of the American Society of Anesthesiologists I/II/III were assigned to Group B (bupivacaine)/Group R (ropivacaine). Before SA, ultrasonography-guided bladder volume was measured. After the operation, bladder volume was measured continuously every 2 hourly until the patient could void urine spontaneously or need of catheterization. Motor blockade and time of ambulation were recorded.
Results: Bromage scale at 4 h was significantly higher (p=0.0001) in ropivacaine showing intrathecal ropivacaine 3.5 mL produce shorter motor blockade then 3.5 mL bupivacaine. Both Group R and Group B were comparable in terms of ability to void urine (p>0.05), time to complete ambulation without support (p>0.05), and time to negative Romberg test (p>0.05). Negative correlation was found between the first spontaneous void urine and the modified Bromage scale.
Conclusions: After SA with bupivacaine, only two patients developed post-operative urinary retention and none in the ropivacaine. However, Group R required lesser time to void and early recovery of motor function. The time to first void urine was more than the time for complete ambulation (1–3.5 h after ambulation).
BEHAVIOR OF BLADDER AFTER TURP IN UNDERACTIVE DETRUSOR PATIENTS
Authors: PRANAB PATNAIK  , GUPTA VIKALAP , DAS SUREN
Published: July 2024

Objective: The gold standard therapy for benign prostatic obstruction is transurethral resection of the prostate (TURP). Because it improves outlet resistance, it may also be useful for individuals who have detrusor underactivity (DU) with lower urinary tract dysfunction that is refractory to medicinal therapy or in situations with a substantial residual urine volume. The objective of the current study was to assess the urodynamic behavior of the bladder following TURP in DU patients.
Methods: This research examined and analyzed 41 individuals with DU (mean age 68.7 years). All these patients had a TURP for a suspected outlet blockage. All these patients had extensive pre-operative evaluations and urodynamics assessments before and after TURP. We compared maximum flow rate (Qmax), international prostate symptom score (IPSS), post-void residuals (PVR), quality of life (QoL) along with other urodynamic parameters assessing detrusor function like bladder contractility index (BCI), and detrusor pressure at Qmax (pdetQmax) pre- and post-TURP.
Results: The average duration of follow-up of patients was 9.2 months. Following TURP, the mean IPSS and QoL improvement was statistically significant. Following TURP, there was also a substantial decrease in PVR while we observed an improvement in Qmax value. Even after TURP, there was no substantial change in total cystometric capacity, BCI, or pdetQmax index.
Conclusion: DU may not be an absolute contraindication to TURP. Despite the presence of DU, the prognosis of TURP may be optimistic if the patients have evident bladder outlet obstruction. However, medically removing the blockage does not increase contractility, which is essential when evaluating and advising on TURP surgery.
Considerations for the Use of AI Tools at the Centre for Social Innovation
Authors: de Pagter Jesse ,   ZSI - Centre for Social Innovation, Schürz Stefanie , Lampert Dietmar
Published: July 2024

The goal of this document is to inform ZSI staff on key aspects relating to the use of AI for work at ZSI, including relevant terms and concepts, legal and regulatory frameworks, and a range of considerations for a responsible and effective use of AI. Moreover, it puts forward a course of action for ZSI in how to integrate AI tools effectively and responsibly in the future. The document closes with an initial set of potential use cases that could serve as a basis for a growing collaborative collection to guide ZSI staff in their work with AI. Since the technological possibilities and regulatory framework surrounding AI is very much in flux at the point of the publication of this document (July 2024), it must be seen as preliminary. ZSI is committed to continuing its active and critical engagement with new and developing technologies to integrate them in a responsible manner into its workflows.
Advancements in Coordination Chemistry and Trends in the Chemical Industry: Applications and Implications
Authors: Chauhan Preeti
Published: July 2024

Abstract: This research paper delves into the current advances in coordination chemistry alongside the evolving trends within the chemical industry, exploring their intersections and applications. Coordination chemistry has witnessed remarkable progress in recent years, driven by innovative synthetic methodologies and a deeper understanding of metal-ligand interactions. The study examines the synthesis and characterization of novel coordination complexes, highlighting their diverse structures and properties. Furthermore, it explores the role of coordination chemistry in various applications, ranging from catalysis and drug design to materials science and environmental remediation. Concurrently, the chemical industry is experiencing transformative shifts, embracing sustainable practices, and adapting to emerging regulatory frameworks. This paper investigates key trends shaping the chemical industry, such as green chemistry initiatives, circular economy principles, and the adoption of advanced manufacturing technologies. By synthesizing the latest research findings and industry developments, this study offers insights into the potential synergies between coordination chemistry advancements and the evolving landscape of the chemical industry, paving the way for innovative applications and sustainable solutions.
Elementary teacher’s perspective critical thinking process in analyzing mathematics problems: Right triangles
Authors: Yayuk Erna , Ekowati Dyah Worowirastri , Restian Arina
Published: July 2024

In the learning process that occurs, many students work quickly, but the results obtained are not accurate. This is because students do not carry out the evaluation process. This research aims to analyze students’ critical thinking processes in solving mathematics problems. The questions discussed are flat geometry material, especially right triangles. The research method used is descriptive qualitative. The subjects were 13 students Elementary School Teacher, Faculty Teacher Training and Education, University Muhammadiyah of Malang. Subjects were selected using the purposive sampling method. The questions were given to 50 potential respondents and only 13 students were able to analyze them correctly. This research has resulted in 13 subjects being able to write information using their language at the interpretation stage. In the analysis stage, this subject can find the latest information by connecting previous knowledge with information obtained while studying in class. Evaluation Stage, 13 subjects were able to carry out the evaluation process by linking the main information found. In the interpretation stage, all subjects can draw a conclusion accompanied by reasons to support the answers and conclusions obtained. Communication and regulation stage, 13 subjects were able to communicate and carry out the process well.
Enhancing elementary learning with Webtoon-based digital comics
Authors: Wulandari Nova Suci , Widodo Susilo Tri
Published: July 2024

One innovative learned media development that could improve student learned outcomes was digital comics. Digital comics was an innovation from printed comics that accessed used the Internet network and are more efficient. This research aimed to develop and tested the feasibility of Webtoon-based digital comic media for applying Pancasila valued. Aparted from that, to found out the effectiveness of media in improved the learned outcomes of class V students during the learning process. This researched used research and development with the waterfall model according to Somerville, which had five stages. The use of the waterfall model in this research is limited to 4 stages: 1) requirements analysis; 2) design; 3) implementation; and 4) testing. The sample in this studied was 6 class V students in small class trial subjects and 23 class V students in significant class trial subjects. Data collection techniques used interviews, validation sheets, and tests. The instruments used were interview sheets, needed questionnaires, validation sheets, response questionnaires, and pretest post-test questioned (20 cognitive questions). The validation results of material and media experts showed that the media is "Very suitable" for the learning process. Teachers and students stated that the media was "Efficient" to use in the learning process. A significant difference existed between student learning outcomes before and after using Webtoon-based digital comic media (T (22) = 9.20, p < 0.05. These findings could have used to expand media distribution to a broader scale.
Regional system of support for small businesses in the Primorsky Territory
Authors: Raevskiy S.V. ,   The Russian Presidential Academy of National Economy  and  Public  Administration
Published: July 2024

The purpose of the article is to reveal the regional system of supporting the development of small businesses in the Primorsky Territory. To achieve this goal, the following tasks are set and solved in the article: the place and the role of small business in the modern economy have been characterized; the criteria for classifying business entities as small businesses have been identified in accordance with the current legislation; specific features of the development of Russian small business have been identified; the leading place of the Primorsky Territory among the regions of the Far-Eastern Federal District in the development of small businesses has been shown; the problems of small business development in the region have been substantiated. The author of the article reveals the system of measures used in the Primorsky Territory to support small businesses. In conclusion, it has been proved that the region has a comprehensive system of institutions for state support of entrepreneurial activity.