bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening of promising targets for the diagnosis and treatment of the aging pituitary gland by bioinformatics
Authors: Wang Ting-Ting , Zhu Gao-Hong
Published: October 2024

Background: Pituitary senescence constitutes a multifaceted process characterized by numerous morphological alterations, functional disruptions, and metabolic impairments within the pituitary tissue. It stands as a pivotal risk factor contributing to the heightened prevalence of neurodegenerative diseases. But the underlying molecular network mechanism remains to be known. Objective: This study analyzed the gene targets of pituitary with aging by bioinformatics, hoping to screen out promising targets for the diagnosis and treatment of aging pituitary. Methods: The GeneCards database (https://www.genecards.org) was utilized to retrieve targets associated with aging and the pituitary. The dataset was filtered using a score threshold of "Relevance score ≥10". Intersection genes were obtained through Venny intersection analysis. Protein-protein interaction (PPI) network analysis, Gene Ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the intersection genes were conducted on these intersection genes. The association between the obtained findings and the aging process of the pituitary gland was explored and compared with the existing literature. Results: Through bioinformatics analysis, we obtained 17 common genes between aging and pituitary-related genes. GO enrichment, KEGG pathway analysis, and PPI interaction showed that the genes IGF1, AKT1, RET, and POMC manifested down-regulation in aging process, whereas, LEP exhibited a marked up-regulation. Moreover, GO analysis reported activation of protein kinase activity, regulation of multicellular organism growth, and glucose metabolic processes within the realm of GO Biological Process (BP) enrichment. Likewise, the GO Cellular Component (CC) enrichment implicated the Wnt signalosome and catenin complex. In terms of Molecular Function (MF), results pointed to receptor ligand activity, insulin receptor binding, and estrogen receptor binding. Moreover, KEGG pathway enrichment analysis highlighted significant pathways associated with aging, such as Growth hormone synthesis, secretion, and action, Breast cancer, Rap1 signaling pathway, and JAK-STAT signaling pathway. Conclusions: We delved into the intricate link between aging and the pituitary gland, and identify several gene targets through the GeneCards database. By analyzing protein interactions, GO, and KEGG pathways, we found the 17 intersecting genes, which could be used to explain the molecular-level connections in the process of pituitary aging.
Scutellarin promotes neuronal function repair in oxygen-glucose deprivation neuronal model by regulating netrin-1 and associated with 3-kinase and protein kinase B
Authors: Rong Rong
Published: October 2024

Background: Oxygen-glucose deprivation (OGD), as a cell model in vitro, is closely related to nerve injury that has been widely used to investigate molecular mechanism and treatment strategy for cerebral ischemia (CI). As a condition injury induced by insufficient blood supply to meet metabolic obstacle, CI commonly results in several injury and cell at involved area, for which, effective treatments are still waiting to be developed. Objective: This study aims to investigate the therapeutic effect of scutellarin on neuronal repair in an OGD model and to determine the underlying molecular mechanism. Methods: Cell experiments were randomly divided into: the normal group, OGD group, OGD with Scutellarin (SCU), administration group, negative control (NC) group, and OGD administrated by SCU with Netrin-1-si group (NTN1). Cortical neurons were firstly extracted and cultured 3 days from SD rat embryos (16-18 days) under aseptic conditions, followed by scutellarin treatment and NTN1 knockdown, together with specimen collection after 24 hours. Analysis included immunofluorescence, Terminal deoxynucleotidyl transferase dUTP Nick End Labeling (TUNEL) staining, and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were employed to assess netrin expression in brain tissue, and cell apoptosis rate was determined. Results: TUNEL and immunofluorescence staining showed a reduced neuronal apoptosis rate in the SCU-treated group, compared to OGD group (p < 0.05). qRT-PCR revealed a decreased NTN1 expression in OGD than seen in normal, while an upregulation was seen in the SCU-treated group compared to OGD (p < 0.05). NTN1 interference increases cell apoptosis and decreased cell count in OGD than in normal one (p < 0.05). Moreover, OGD with NTN1 knockdown administrated by SCU leads to increased cell apoptosis than in OGD administrated by SCU only. Mechanismly, qRT-PCR indicated Protein Kinase B/Phosphoinositide 3-kinase (AKT/PI3K) expression was involved in this process. Conclusions: Scutellarin may regulate NTN1 expression and affect the P13K/AKT pathway, thereby contributing to neuronal recovery in OGD model. These findings may provide a reference for the clinical treatment of CI in later clinical trials.
Prediction of patients with ovarian hyperstimulation syndrome in gonadotropin-releasing hormone agonist prolonged protocol: a retrospective study
Authors: Ya Wen , He Li-Mei , Rao Meng , Zheng Yu-Hang , Wang Hua-Wei , Su Cun-Mei , Tang Li , Yang Ze-Xing
Published: October 2024

Background: Ovarian Hyperstimulation Syndrome (OHSS), a life-threatening complication and the most common adverse effect of fertility treatment, currently lacks an effective prevention method. Objectives: We investigated associated risk factors of OHSS in stimulated ovarian cycles with assisted reproductive technology (ART), with the aim of providing guidance for clinicians on how to prevent OHSS. Methods: A logistic regression analysis was conducted on 336 patients who had completed in vitro fertilization (IVF)-intracytoplasmic sperm injection (ICSI)/embryo transfer (ET) cycles between April 2019 and April 2021 in the first affiliated hospital of Kunming Medical University. Receiver-operating characteristic (ROC) curves for OHSS were calculated for each predictor using cut-off values. Area under the curve (AUC) analysis and logistic regression models were performed to compare the performance of laboratory biomarkers. Results: According to clinical diagnosis, 61 out of 336 cycles experienced OHSS, resulting in an incidence rate of 18.15%. Patients were graded based on their clinical symptoms and severity, with 27 instances of moderate OHSS (8.04%) and 8 cases of severe OHSS (2.38%). The cut-off values for anti-Müllerian hormone (AMH), Estradiol (E2) on Human Chorionic Gonadotropin (HCG) day, and eggs retrieved to predict moderate and severe OHSS were determined as 7.495 ng/ml, 4828 pg/ml, and 19.5, respectively, in the Gonadotropin-Releasing Hormone agonist (GnRH-a) Prolonged Protocol. The sensitivities for these parameters were 77.0%, 67.2%, and 80.3%, with specificities of 68.0%, 70.9%, and 81.5%, respectively. AUC values for AMH, E2 on HCG day, and the number of retrieved oocytes, predicting moderate and severe OHSS, were 0.754, 0.738, and 0.876, respectively. Additionally, the combined index yielded an AUC value of 0.898, attaining the highest AUC with 85.2% sensitivity and 83.6% specificity. Conclusions: AMH, E2 on the day of HCG administration, and the total number of retrieved eggs collectively exhibit a robust predictive influence on the occurrence of OHSS. The predictive efficacy is enhanced significantly when these three indicators are combined.
Identification of Supply Chain Disruption Risks and Strategies in the Electric Vehicle Industry Based on Fuzzy Analytic Hierarchy Process (FAHP)
Authors: Li Xinyi
Published: October 2024

In recent years, the electric vehicle industry has witnessed unprecedented development opportunities. However, with rapid technological iterations and fluctuating market demands, the vulnerability and complexity of the electric vehicle supply chain have significantly increased the potential risk of supply chain disruptions. Against this backdrop, this study adopts the Fuzzy Analytic Hierarchy Process (FAHP) to systematically analyze the risks of supply chain disruptions in the electric vehicle industry. By constructing a judgment matrix through industry data surveys and expert scoring, and conducting consistency checks, the weights of various risk factors are determined. The study finds that technological quality risk, demand forecast deviation, and logistics disruption are the primary factors affecting the stability of the electric vehicle supply chain. Additionally, although the probability is relatively low, the potential destructiveness of exogenous risks is equally undeniable. Accordingly, the study will propose targeted management strategies to enhance the resilience of the new energy vehicle supply chain at both the enterprise and industry levels in response to these risks.
A Study On The Impact of The Digital Economy on China’s Carbon Neutrality Capability
Authors: Wu Shangxu
Published: October 2024

The digital economy is a new economic form driven by digital technology, which contains green and low-carbon effects and can promote the transition to a resource-saving and environmentally friendly society. This paper explores the impact of the digital economy on carbon neutrality capability using panel data from 30 provinces in China between 2013 and 2021and finds that the digital economy has a positive effect on carbon neutrality capability with non-linear characteristics. It has a positive and then a negative effect on carbon reduction capability, as well as a positive effect on carbon removal capability. The digital economy can aid various societal actors in enhancing carbon neutrality capability by promoting corporate technological innovation, encouraging public green consumption, and adjusting government environmental regulations.
Cross-ownership and Corporate Innovation
Authors: Zhang Wenlu
Published: October 2024

This article takes Chinese A-share listed companies from 2014 to 2022 as the research sample, and uses a multiple regression model to empirically test the relationship between cross-ownership and corporate innovation efficiency. Research has found that: (1) cross-ownership can improve the innovation efficiency of enterprises. (2) when the internal control quality of the enterprise is high and the legal system environment is good, the promoting effect of Cross-ownership on the innovation efficiency of the enterprise is more significant.
Comprehensive Analysis of Football Player Market Valuation: Integrating Performance Metrics and Marketability Factors
Authors: Cai Jiaxuan
Published: October 2024

In the fast-paced world of professional football, valuing players involves numerous factors. This paper explores the determinants of football players' market values using a mixed-methods approach. Quantitative data from sources like Opta Sports, Transfermarkt, and the CIES Football Observatory, along with qualitative insights from semi-structured interviews with industry experts, were analyzed. The quantitative analysis found that goals scored and social media followers significantly predict player market value, with a strong social media presence amplifying the impact of goals. Non-linear relationships revealed diminishing returns on market value as social media followers increase. Qualitative insights highlighted the importance of media presence, cultural impact, and digital engagement in shaping player valuations. Players frequently featured in media, seen as cultural icons, or active on digital platforms tend to have higher market values. A comparison with historical data showed a growing emphasis on marketability and digital presence. The study concludes that integrating quantitative performance metrics with qualitative marketability factors is crucial for accurate player valuation. This holistic approach offers valuable insights for clubs, agents, and policymakers, enhancing decision-making in player transfers and contract negotiations. The research contributes to sports management and economics by providing a comprehensive framework for managing player assets in professional football.
TCL Technology's Merger and Acquisition of Central Electronics: Analysis of Corporate M&A and Restructuring Strategies
Authors: Liu Li
Published: October 2024

Benefiting from national policy support and market economy, China's semiconductor industry has made significant progress in technological innovation, especially in the context of 5G, smart Internet and big data era, the center of gravity of the industry is shifting from South Korea and Taiwan to mainland China.Through the acquisition of Azeus, which is equipped with profound semiconductor packaging and testing technology, TCL Technology aims to enhance its competitiveness in the semiconductor field, optimize supply chain management and improve product quality control capability. supply chain management and improve product quality control. This paper examines TCL's acquisition of Azeus and discusses six aspects of the acquisition: overview of the two parties, industry background, progress of the acquisition, performance evaluation (including financial and non-financial), risk analysis, and characteristics of the acquisition. The results show that the acquisition has had a positive impact on TCL's development in semiconductors and related fields.
The Impact of Financial Information Transparency on Corporate Governance Effectiveness
Authors: Wang Jingxuan
Published: October 2024

In today’s rapidly changing business environment, financial information transparency has become a key indicator for measuring the quality of corporate governance. This paper introduces the basic concept of financial information transparency, the relationship between financial information transparency and corporate governance, and focuses on the impact of financial information transparency on stakeholders, challenges and strategies to improve financial information transparency, and finally predicts the development trend of financial information transparency. It is hoped that the analysis of these issues will be helpful in improving the transparency of corporate financial information and promoting more effective and transparent corporate governance practices.
Consumer Behavior in the Digital Marketplace: A Fuzzy Evaluation Approach
Authors: Zhan Wenxi
Published: October 2024

With the growing prevalence of the internet and the development of logistics, consumers face increasingly complex choices when shopping online. Therefore, this article introduces fuzzy comprehensive evaluation to address these shopping issues. In analyzing consumers' purchase decision-making problems for online shopping, it is essential to subjectively evaluate products, such as price, quality, and reputation. By constructing fuzzy relationships and assigning weights, this method effectively handles the ambiguity and uncertainty of evaluation information, reflecting consumers' subjective preferences in actual shopping decisions. This study concludes that quality is the dominant factor among numerous commodity factors,and it also established a shopping decision model, which aids consumers in making the best decisions during their shopping, thereby enhancing shopping efficiency and satisfaction. The results indicate that compared to traditional methods, this method can more accurately focus on consumer purchase intention and improve the understanding of shopping decisions. The paper summarizes the fuzzy comprehensive evaluation of its application value in shopping problems, pointing out that it can better simulate human fuzzy decision-making processes and provide a more practical shopping decision assistance tool. This study not only enriches the application of fuzzy comprehensive evaluation theory in consumer behavior research, but also provides consumers with a scientific and practical shopping decision support method.
Common Institutional Ownership and Auditor Risk Response
Authors: Cheng Cheng
Published: October 2024

Based on the data of China's Shanghai and Shenzhen A-share listed companies from 2010 to 2021, this paper investigates the relationship between a company's common institutional ownership and auditors' risk response behavior. The study shows that common institutional ownership drives auditors to increase audit investment and audit fees, which supports the collusive fraud effect. Further analysis reveals that the effect of common institutional ownership on auditor risk response behavior is more pronounced in firms with a higher degree of industry competition as well as in state-owned enterprises, and that Big Four auditors will be more sensitive to the collusive fraud effect of common institutional ownership and respond to this risk mainly by increasing audit investment. This paper not only enriches the research literature on the factors influencing auditors' risk response behavior and the economic consequences of common institutional ownership but also sheds light on how to improve corporate governance and regulate the market order in practice.
Optimize Airline Service Policy Based on Airline Passenger Satisfaction Data Analysis
Authors: Tian Shiyuan
Published: October 2024

As the preferred means of transportation for long-distance travel after the epidemic, whether an airline can stand out among its peers is deeply related to whether it can satisfy passengers, and the service quality of an airline can significantly affect passenger satisfaction. In this paper, random Forest is applied to judge the correlation between satisfaction and different service factors, and several factors that have the most significant impact on satisfaction are selected. The results show that the influence degree of Online. boarding, Inflight. wifi. service is significantly higher than other factors. Then, Legroom service, Inflight entertainment, departure-arrival time convenience, and Seat comfort are four factors with significant influence. Therefore, this paper believes that airlines should provide convenient online registration, rich flight entertainment activities, and comfortable seat space to improve passenger satisfaction under the premise of ensuring that their costs do not change much. In this way, airlines can greatly improve their competitiveness to attract and retain more loyal passengers.
Advanced Analytics for Retail Inventory and Demand Forecasting
Authors: Chen Junwei
Published: October 2024

Achieving operational efficiency and enhancing customer satisfaction levels in the retail sector is directly dependent on efficient inventory management and accurate demand forecasting. The following study employs advanced analytics techniques, such as time series forecasting and machine learning, to bolster these essential functions. By leveraging on historical sales data from 45 retail stores sourced by Kaggle, this paper has constructed predictive models with the aim to optimize inventory levels and forecast demand with precision. The Seasonal AutoRegressive Integrated Moving Average with Exogenous Regressors (SARIMAX) model employed in this study adequately captures linear dependencies and seasonal patterns, while Long Short-Term Memory (LSTM) networks are responsible for the management of intricate, non-linear dependencies. The findings from this study depict the significant seasonal trends, the impact of economic factors, the impact of economic variables and the effectiveness of hybrid models in improving forecast accuracy. The integration of such advanced methodologies clearly highlights their massive potential in improving aspects such as inventory management and operational efficiency in the retail domain.
Overseas Returnee Executives and Digital Transformation of Enterprises: From the Perspective of Executive Compensation Gap and Executive Overconfidence
Authors: Huang Qi , Xu Yuhang , Tu Shiming
Published: October 2024

This article selects panel data of A-share listed companies in Shanghai and Shenzhen from 2013 to 2022, uses a fixed effects model to study the relationship between overseas returnee executives and digital transformation of enterprises, and analyzes the moderating effects of executive compensation gap and executive overconfidence. The research results indicate that overseas returnee executives can significantly promote the digital transformation of enterprises; The salary gap and overconfidence of executives play a negative moderating role in the positive relationship between overseas returnees executives and digital transformation of enterprises; Heterogeneity analysis shows that overseas returnee executives have a greater impact on high-tech enterprises, low marketization areas, and enterprises in the eastern region than on non-high-tech enterprises, high marketization areas, and enterprises in the central and western regions. To better solve the problems of "not being able to transform", "unwilling to do", and "afraid to transform" in the process of enterprise digital transformation, firstly, it is necessary to effectively utilize the high-quality human resources of overseas returnee executives and provide them with reasonable care and support to better play their role; The second is to optimize the executive compensation structure and strengthen the correlation between compensation and performance; The third is to pay attention to leadership training and psychological counseling for executives, and ensure objective analysis and sufficient discussion in the decision-making process of digital transformation.
Behavioral Economics Strategies to Improve Medication Adherence in Diabetes
Authors: Qiao Haobo
Published: October 2024

Nowadays, diabetes has become an international challenge. In spite of the great technological advances in human society compared to a few decades ago, a cure for this disease has never been discovered. Hundreds of millions of patients are suffering from it, and in order to enable diabetics to keep their condition as stable as possible, this paper examines how to enhance patients' medication adherence from the perspective of behavioral economics. After reclassification of the influencing factors through tables such as pivot tables, among the data of 1127 patients selected who required long-term medication, 559 were affected by Convergence and Avoidance of Harm and were reluctant to take medication. Another 231 participants suffered from cognitive bias. A further 165 patients made irrational calculations about whether or not to take their medication. The remaining patients were influenced by some objective factors. Based on the analysis of the distinct causes of medication non-adherence in diabetic patients, it was found that this could be tackled by allowing patients to be more informed about their condition, improving access to education in order to break down information barriers, increasing the presence of family and friends, and illustrating the cost of treatment with the help of visualization tools. Beyond financial and dietary approaches, these facilitation methods could nudge as much to stabilize patients' medication-taking behaviors.
Investigation on Influence Factors of the C-REIT Market: Applying the Fama-French Three-Factor Model
Authors: Huang Mingda
Published: October 2024

This research paper has applied the Fama-French Three-Factor Model to the China Real Estate Investment Trust (C-REIT) market over a two-year period from June 2022 to June 2024. The innovation is recognized as the C-REIT market was established in 2021 with the first 9 REITs issued and few researches were conducted on the C-REITs. The study obtained data from the Wind database in the after-COVID period and concluded that the model fits well for the behavior of the Chinese REIT market. The market premium factor is found to be positive, while the size factor (SMB) is negatively significant, and the value premium (HML) is positively significant. This suggests that REITs with smaller market capitalization and those with a higher book-to-market ratio are more likely to contribute to the portfolio's excess returns. The intercept in the regression is statistically significant and that implies that there may be additional factors that are not captured by the current model. As such, the paper advocates for further research into multi-factor models to explore potential factors.
Analysis of Earnings Quality and Enterprise Valuation of Microsoft by Earnings Quality and Residual Income Model
Authors: Jiang Ruitao
Published: October 2024

Artificial intelligence has had a remarkable influence in recent years and has developed many revolutionary solutions in many industries. OpenAI’s ChatGPT is one of the most popular products in this trend. As the largest stockholder of OpenAI, Microsoft has committed itself to integrating artificial intelligence into its primary products, like Microsoft Office and Azure. Although Microsoft experienced a continuous slump in stock in 2022, Microsoft’s current stock price has broken through $400 per share. This paper aims to conduct a financial analysis and forecast Microsoft’s future growth to figure out Microsoft’s intrinsic value. This article uses earnings quality analysis and residual income model to evaluate Microsoft’s financial performance and conduct valuation. Microsoft’s Cash Conversion Cycle has become negative since 2021, so Microsoft can reinvest the cash it receives from sales before using it to pay suppliers. The present value of the continuing value in the Residual Income Model indicates that Microsoft is undervalued compared to the current stock price. Economic conditions and the global supply chain will also influence investors’ expectations, except for quantitative factors. Therefore, Microsoft's stock price fluctuates and does not exceed the forecasted price. This article offers some insights on Microsoft and relevant industry valuation analysis.
The Research on Influence Factors of Red Wine Quality
Authors: Liu Tianze
Published: October 2024

Nowadays, product quality certificates are being used by enterprises to market their products. This is an expensive and ineffective process that takes a long time and requires assessments from customers and human experts. Determining the relationship between a red wine's chemical composition and subjective quality is a difficult task. This paper investigates the use of statistical methods, such as linear regression, to predict the values of target variables and ascertain how dependent the target variable is on the independent factors. It is more accurate than previous methods. These results contribute to the understanding of how different red wine consumers perceive quality and can help the red wine industry identify the primary sensory-active ingredients that influence quality in different red wines. The paper uses linear regression to solve the problem. The research examines at those factors' VIF value and significance in order to assess the efficacy of this operation. It turns out that volatile acidity, chlorides, total sulfur dioxide, sulphates and alcohol have a significant linear relationship with red wine quality, while the other factors have less influence on red wine quality. Overall, red wine quality can be evaluated based on how much these variables affect them.
Research on Factors Influencing Medical Insurance Cost in the US
Authors: He Quanjing
Published: October 2024

After the COVID-19 epidemic, the growing concern over medical insurance cost and the factors that influence it are increasingly coming to the forefront. These factors include age, sex, body mass index, number of children, smoker or non-smoker and region. Therefore, this paper analyzes the impact of six factors on medical insurance costs by utilizing data on medical insurance expenses of 2,772 individuals in the US. The analysis employs a multiple linear regression model and the stepwise regression method. It is concluded that age, body mass index, number of children, smoker or non-smoker and region have a significant impact on medical insurance cost with the largest regression coefficients for age, body mass index and smoker or non-smoker. This shows that it is physiological factors that have the greatest impact and therefore it is recommended that people should better maintain good health in order to reduce medical insurance cost and save money.
MENINGKATKAN MINAT BERWIRAUSAHA MELALUI PELATIHAN SOSIAL MEDIA MARKETING DAN PRODUCT PHOTO STYLING BAGI SISWA SMA NEGERI 2 SLAWI
Authors: Qusaeri Muammar Afif Al , Wiliyanto Wiliyanto , Khasanah Muthi’atul , Khasbulloh M. Wahab , Musripah Musripah , Atmoko Dwi , Subekti Agung Tyas
Published: October 2024

Tujuan pengabdian kepada masyarakat ini adalah pengembangan jiwa entrepreneurship bagi siswa SMA Negeri 2 Slawi melalui Sosial Media Marketing dan Product Photo Stailing. Metode atau tahapan untuk pengembangan jiwa entrepreneurship yang dilakukan peneliti yakni melalui pelatihan menjadi wirausaha. Dimana metode pengabdian kepada masyarakat yang digunakan adalah dengan interaksi langsung melalui diskusi dan praktek dalam rangka pengembangan jiwa entrepreneurship. Hasil evaluasi terhadap peserta pengabdian kepada masyarakat menunjukkan tercapainya tujuan pengabdian kepada masyarakat, dimana adanya peningkatan pengetahuan siswa setelah diberikan materi kewirausahaan. Peserta dalam kegiatan ini adalah siswa SMA Negeri 2 Slawi. Berdasarkan hasil kegiatan dapat ditarik kesimpulan bahwa secara umum siswa berminat untuk menjadi seorang entrepreneurship, namun terkendala dengan keterbatasan pengetahuan, pengalaman, dan biaya
Ozone therapy in periodontal disease in type 2 diabetic patients
Authors: Pérez Ayala Danisbel , Labrador Falero Dunia Milagros , Martínez Pita Milenis , Cáceres González Ivette , Wong Silva Jadier
Published: October 2024

Introduction: periodontopathies are frequent in the world population and Cuba does not escape from this situation. In the search for more effective treatments, ozone therapy is a therapeutic alternative.
Objective: to determine the efficacy of oleozon in the treatment of periodontal disease in diabetic patients.
Methods: quasi-experimental study of therapeutic intervention in patients with diabetes mellitus type 2 and periodontal disease who attended Periodontics consultation at the "Hermanos Saiz" Stomatological Clinic of San Juan y Martínez, Pinar del Río in the period November 2023-April 2024. Universe: 125 patients. By means of intentional sampling by expert criteria, the sample was 96 patients, divided into 2 homogeneous groups: group I (oleozon) and group II (aqueous chlorhexidine 0.2 %). The Russell Periodontal Index, a revised WHO form to determine prevalence and severity of periodontal disease, was applied. The results were expressed in absolute and percentage frequencies and the non-parametric Chi-square test.
Results: Male patients and the 50-60 years age group predominated with higher numbers of advanced periodontitis in both groups before and after treatment. Bleeding on probing was eliminated 21 days after treatment in both groups. Most of the patients were cured after 21 days and the treatment applied was successful in both treatment groups.
Conclusions: Oleozon is an effective drug in the treatment of chronic inflammatory periodontal diseases in diabetic patients
Advancing Medical Image Analysis: The Role of Adaptive Optimization Techniques in Enhancing COVID-19 Detection, Lung Infection, and Tumor Segmentation
Authors: Muhyeeddin Alqaraleh , Mowafaq Salem Alzboon , Al-Batah Mohammad Subhi , Mutaz Abdel Wahed
Published: October 2024

Artificial intelligence (AI) holds significant potential to revolutionize healthcare by improving clinical practices and patient outcomes. This research explores the integration of AI in healthcare, focusing on methodologies such as machine learning, natural language processing, and computer vision, which enable the extraction of valuable insights from complex medical imaging and clinical data. Through a comprehensive literature review, the study highlights AI’s practical applications in diagnostics, treatment planning, and predicting patient outcomes. Additionally, ethical issues, data privacy, and legal frameworks are examined, emphasizing the importance of responsible AI usage in healthcare. The findings demonstrate AI’s ability to enhance diagnostic accuracy, streamline administrative tasks, and optimize resource allocation, leading to personalized treatments and more efficient healthcare management. However, challenges remain, including data quality, algorithm transparency, and ethical concerns, which must be addressed to ensure safe and effective AI deployment. Continued research, collaboration between healthcare professionals and AI experts, and the development of robust regulatory frameworks are essential for maximizing AI’s benefits while minimizing risks. This research underscores the transformative potential of AI in healthcare and stresses the need for a multidisciplinary approach to address the ethical and regulatory complexities involved in its widespread adoption
Udeboende børn som pårørende – Når far er syg
Authors: Sommer-Lykke Emilie Christine , Farsinsen Gundorff Nielsen Helle , Lykke Camilla
Published: October 2024

Resumé Baggrund Udeboende børn som pårørende til en alvorlig syg forælder er en sårbar og overset gruppe. Formål At undersøge hvilke behov patienter med uhelbredelig tarmkræft og deres udeboende børn i alderen 18-28 år har for støtte og inddragelse i fædrenes sygdomsforløb, og hvordan sygeplejesker kan støtte dem. Metode Et kvalitativt studie indeholdende tre semistrukturerede interviews med tre mandlige patienter med uhelbredelig tarmkræft. Resultater Projektet viser fem temaer: ”Den mandlige patient - Når far er syg”, ”Usynlig sygdom”, ”Åben og ærlig kommunikation”, ”Forældreskab som største bekymring”, ”Mit barns behov”. Konklusion Patienterne har behov for åben og ærlig kommunikation med deres børn om sygdommen, men oplever bekymring forbundet med ærligheden. Et paradoks ses mellem patientens behov for at bevare normaliteten og deres børns behov for information. Manglende tilbøjelighed til at tage imod tilbud om støtte og vejledning, kan være kønsbetinget. Sundhedsprofessionelle har ansvaret for at identificere de udeboende børn og deres behov samt formidle tilbud om støtte. Nøgleord: Kommunikation, palliativ indsats, tarmkræft, udeboende børn, pårørende inddragelse, uhelbredelig sygdom.
Forskningsstrategi: Hvorfor, hvordan og med hvilke teoretiske redskaber kan sygeplejefaglige forskningsstrategier udarbejdes
Authors: Beck Malene , Pedersen Anita , Hølge-Hazelton Bibi
Published: October 2024

Resume Vores artikel beskæftiger sig med de teoretiske lag af udarbejdelsen af en forskningsstrategi inden for sygepleje. Vi undersøger de grundlæggende argumenter for, hvordan, hvorfor, og hvilke redskaber der kan anvendes i denne komplekse proces med at producere forskningsstrategi med et sygeplejefagligt fokus. Ved at sætte fokus på sygeplejeteori udforsker vi, hvordan disse kan informere og styrke udviklingen af en forskningsstrategi. Artiklen tilbyder læserne at fordybe sig i rationale, metoder og indsigter om, hvordan sygeplejepraksis kan beriges gennem en systematisk udarbejdet forskningsstrategi. Vores mål er ikke at præsentere en opskrift, men at understrege betydningen af sygeplejeteori som fundamental hjørnesten til at udvikle en bæredygtig strategi inden for sygeplejepraksis og forskning.
Spiritual Experience as a Predictor of Organizational Commitment among Nurse Educators in Government Higher Education Institutions
Authors:   Pamantasan ng Lungsod ng Maynila, Ramos David Paul , Habig Edith ,   University of Santo Tomas
Published: October 2024

Filipino spirituality is deeply rooted in their sense of meaning. In Filipino culture, spirituality transcends the religious aspect. This study aimed to determine if spiritual experience is related to and can predict organizational commitment among nursing educators. By examining how spiritual experience is related to organizational commitment, the research aimed to provide evidence of what can potentially predict loyalty to the workplace among nursing educators. The study utilized survey questionnaires to measure spiritual experience and organizational commitment. The questionnaires were administered online through Google Forms to 80 nurse educators currently teaching in government higher education institutions (HEIs) in the CALABARZON and NCR areas. Data analysis was conducted using JAMOVI. Participants have high (frequent) spiritual experience and average organizational commitment. Results revealed significant positive relationship between spiritual experience and affective commitment; spiritual experience and normative commitment; and spiritual experience and overall organizational commitment (total scale). Spiritual experience was also found to significantly predict affective commitment, normative commitment, and overall organizational commitment. Spiritual experience was not related to and did not predict continuance commitment. This study demonstrates that fostering and promoting the practice and expression of nurse educators' spirituality in the workplace may enhance organizational commitment. The findings of this study advocate for the integration of spirituality in the workplace, fostering an organizational culture centered on spirituality, wherein individuals discover meaning and purpose in their work.
EXPLORING THE EMERGING AREAS OF CORPORATE DISCLOSURES: A BIBLIOMETRIC ANALYSIS
Authors: Agrawal Sakshi , Marvadi Chetana
Published: October 2024

In the current Indian scenario of the financial reporting regime, stakeholders are increasingly looking at the disclosure practices of the companies. Therefore, higher level of transparency is required which implies that there is need of higher level of disclosure. In the present era, the sources of information are not only restricted to annual reports for stakeholders to take decisions. Hence, it is very crucial to have encyclopaedic study on corporate disclosures. The main objective of this paper is to determine the current state of research on corporate disclosure practices across the world. In the present study, literature in subject areas business, management, accounting, economics, econometrics, and finance has been retrieved from Scopus Database and analysed for 15 years between 2009 & 2023. The bibliometric analysis has been conducted using VOS Viewer. This study highlights the trend of publication across two decades, countries and journals along with most cited papers, top journals, most influential authors. Finally, through co-occurrence analysis of keywords, least explored areas have been identified. This paper highlights the gap in the available literature and make recommendations for future research in emerging areas.
A Morris Semiotic Perspective on the Characteristics and Cultural Significance of Traditional Guangdong Furniture Patterns
Authors: Yi Xi qiong , Yong Yuan , Abas Imelda Hermilinda
Published: October 2024

Based on Morris's semiotic theory, this paper systematically analyzes the symbolic features of traditional Guangdong furniture patterns and their cultural symbolism from the three dimensions of semiotics (syntax, semantics, and pragmatics). The study focuses on typical patterns such as dragon and phoenix, pine and crane, plum, orchid, bamboo and chrysanthemum in Guangdong traditional furniture, and explores their historical origins, social functions, and close links with Confucianism, family concepts, and social hierarchies in the context of Lingnan culture. By analyzing these symbols, the paper reveals their special symbolic meanings in different social classes and ritual cultures, as well as how they convey the values and lifestyles of the Guangdong region through visual forms. The study further explores the potential application of these traditional symbols in modern design, especially through simplification and abstraction, combining traditional cultural symbols with modern design concepts, materials and techniques to realize the fusion of cultural heritage and innovative design. This paper provides a new theoretical framework for the study of the patterns of traditional furniture in Guangdong, and practical suggestions for modern designers on how to effectively inherit and innovate the cultural heritage symbols, and to promote the synergistic development of cultural heritage preservation and design industry.
Unraveling Capability and Capacity of Parallel Diplomacy Governance in Indonesia: How Far Are Indonesia’s Regional Governments Ready to Go?
Authors: Dermawan Windy , Alam Gilang Nur , Djuyandi Yusa , Ridzuan Abdul Rauf
Published: October 2024

Dewasa ini, praktik diplomasi tidak hanya dilakukan oleh aktor negara saja, tetapi juga aktor lainnya, salah satunya aktor daerah. Aktor daerah kini telah melakukan hubungan internasional dari berbagai sektor yang didasarkan pada kebutuhan daerah. Fenomena tersebut merupakan hal yang lumrah di daratan Eropa, bahkan praktik diplomasi yang dilakukan aktor daerah tersebut telah masuk dan berkembang di Indonesia. Hal ini dapat ditinjau melalui tata kelola diplomasi paralel di Indonesia yang dibangun oleh aspek yuridis, pararelitas, dan tata cara pelaksanaan. Meskipun begitu, pada praktiknya, kapabilitas dan kapasitas pemerintah daerah dalam melaksanakan aktivitas diplomasi paralel yang menjadi salah satu penentu keberhasilan diplomasi daerah. Riset ini bertujuan untuk mengeksplorasi kapasitas dan kapabilitas aktor daerah di Indonesia, baik secara institusional maupun personal, dengan merujuk pada Konsep Paradiplomasi (Diplomasi Paralel) dan tata kelola, Kapabilitas, dan Kapasitas. Periset menggunakan pendekatan kualitatif melalui wawancara terhadap sejumlah informan yang relevan, internet-based research, studi dokumentasi, dan juga studi kearsipan. Riset ini menemukan bahwa kapasitas dan kapabilitas aktor daerah di Indonesia dalam melaksanakan diplomasi paralel masih belum merata dan optimal. Hal ini dapat dilihat melalui dua aspek, yaitu besaran anggaran dana yang berbeda-beda dan pengelolaannya yang masih kurang optimal serta terbatasnya pengetahuan terhadap aspek regulatif hingga praktik diplomasi oleh aparatur sipil negara di daerah.
Ranolazine New Potential Therapeutic Aspects
Authors: Bahgat Mennatallah M. , Taye Ashraf , Kamel Esam Omar , Wazeery Abdulhakim Erian Mustafa , Ellisy Reham A.M.
Published: October 2024

Since Ranolazine approval as an antianginal medication by the US Food and Drug Administration in 2006, it has been administered to specific patient populations with stable angina. Originally, it was thought that ranolazine's therapeutic actions were due to its inhibition of the metabolism of fatty acids. However, as research progressed, it became clear that ranolazine's primary advantageous benefits come from its influence on the heart's late sodium current. Numerous experimental and clinical studies have tested ranolazine either directly or indirectly on heart failure since late-sodium currents have been found to be involved in various heart pathologies such as ischemia, arrhythmias, systolic and diastolic dysfunctions, and all these conditions are associated with heart failure. The inhibition of the underlying mechanisms of cardiac remodeling, such as ion disruptions, oxidative stress, inflammation, apoptosis, fibrosis, metabolic dysregulation, and neurohormonal dysfunction, by ranolazine is reviewed after any kind of severe injury, along with open questions. Ranolazine additional metabolic properties contribute to its efficacy in treating conditions other than coronary artery disease. Our publication will focus on potential therapeutic applications of ranolazine, extending beyond cardiology.
Peran Lembaga Pemasyarakatan Dalam Upaya Pembinaan Terhadap Pelaku Residivis Tindak Pidana Narkotika
Authors: Rian Tuta  , Dian Ekawaty Ismail  , Mohamad Rivaldi Moha
Published: October 2024

The purpose of this activity is to determine the success of the role of efforts to develop the Gorontalo Class IIA Penitentiary for prisoners, one of which is prisoners who have a high level of awareness so that there will be no repetition of narcotics crimes (narcotics recidivism). The research method used is a type of empirical legal research, namely the Sulatul Meltholm research method, which has the ultimate function of seeing law in a real sense and studying how law works in the social environment. The results of the research obtained on the role of Correctional Institutions in efforts to guide recidivist perpetrators of narcotics crimes in Gorontalo Class IIA Prisons have not been effective. The factors that hinder efforts to provide guidance to recidivist narcotics criminals are the lack of differences in guidance between narcotics recidivists and non-recidivist perpetrators, overcapacity in prisons, a lack of officers, and a low level of supervision. The author's suggestions for overcoming existing obstacles are to separate the guidance given to narcotics recidivists and non-recidivists, improve prison infrastructure, including adding officers, which can improve supervision in prisons.
Pendampingan UMKM: Meningkatkan Daya Saing Dan Inovasi di Era Digital Pada UMKM Bintang Emas di Desa Kasengan, Kecamatan Manding, Kabupaten Sumenep
Authors: Moh. Kurdi  , Dina Arifatun Nisa  , Unsilatur Rahmah  , Dewi Intan Andini  , Riana Suci Ardianty  , Muhammad Amir  , Mohammad Ahsani Taqwim  , Ary Wahyudi
Published: October 2024

The SME assistance program entitled "SME Assistance: Enhancing Competitiveness and Innovation in the Digital Era for Bintang Emas SMEs in Kasengan Village, Manding Subdistrict, Sumenep Regency" was implemented from March 1, 2024, to May 31, 2024. This program aims to enhance digital capacity, product innovation, and modern marketing strategies for Bintang Emas SMEs. Through digital marketing training, product innovation workshops, and technical assistance, participants learn to utilize digital technology and e-commerce platforms to enhance the visibility and sales of their products, including the flagship product of cassava chips. The results showed a 25% increase in sales in the first three months, an improvement in product variety and quality, as well as an enhancement in business and financial management skills. This program also successfully fostered a spirit of mutual cooperation and collaboration in the local community and strengthened the relationship between SMEs and the surrounding community. With these achievements, it is hoped that Bintang Emas SMEs will continue to innovate and adapt to market changes, providing sustainable benefits to the local economy and the welfare of the local community.
Pengabdian Masyarakat melalui Kegiatan Pemanfaatan Pojok Baca untuk Meningkatkan Pengetahuan Literasi Membaca Anak melalui Kegiatan Membaca Desa Jenggalu Dusun III Mekar Sari
Authors: Agustya Erawati  , Suci Dwi Putri  , Anggita Novitasari  , Bayu Lailatul Hasanah  , Sinar Komalasari  , Saadah Mardliyati
Published: October 2024

The activity of placing a Reading Corner as an effort to support the increase in community interest in reading in Jenggalu Village, Dusun III Mekar Sari is a community service activity motivated by a joint effort to increase literacy and interest in reading among the village community because in Jenggalu Village, Dusun III Mekar Sari does not provide a reading corner. This program aims to improve the literacy skills of the community with the support of a reading corner as well as being able to bring reading materials closer to the community while in Jenggalu Village Hamlet III Mekar Sari. The implementation methods used in community service include discussion methods, promotion and placement of reading corners in Jenggalu Village Hamlet III Mekar Sari. This activity involved village officials in the discussion and promotion process as well as the community so that on the first day after the initial laying of the reading corner the number of visitors was quite a lot, namely 16 people and the visitors' responses were very positive and felt lucky because in Jenggalu Village Dusun III Mekar Sari there was already a reading corner that not only benefited the village but also the people of Jenggalu Village Dusun III Mekar Sari in increasing reading literacy in Jenggalu Village Dusun III Mekar Sari