bluuebunny/crossref_metadata_2025 huggingface dataset:
Endogenous Anti-Cancer Candidates in GPCR, ER Stress, and EMT
Authors: Gundamaraju Rohit , Lu Wenying , Azimi Iman , Eri Rajaraman , Sohal Sukhwinder Singh
Published: October 2020

The majority of cellular responses to external stimuli are mediated by receptors such as G protein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress). Since GPCR signalling is pivotal in numerous malignancies, they are widely targeted by a number of clinical drugs. Cancer cells often negatively modulate GPCRs in order to survive, proliferate and to disseminate. Similarly, numerous branches of the unfolded protein response (UPR) act as pro-survival mediators and are involved in promoting cancer progression via mechanisms such as epithelial to mesenchymal transition (EMT). However, there are a few proteins among these groups which impede deleterious effects by orchestrating the pro-apoptotic phenomenon and paving a therapeutic pathway. The present review exposes and discusses such critical mechanisms and some of the key processes involved in carcinogenesis.
Attention Networks in ADHD Adults after Working Memory Training with a Dual n-Back Task
Authors: Dotare Masashi , Bader Michel , Mesrobian Sarah K. , Asai Yoshiyuki , Villa Alessandro E. P. , Lintas Alessandra
Published: October 2020

Patients affected by Attention-Deficit/Hyperactivity Disorder (ADHD) are characterized by impaired executive functioning and/or attention deficits. Our study aim is to determine whether the outcomes measured by the Attention Network Task (ANT), i.e., the reaction times (RTs) to specific target and cue conditions and alerting, orienting, and conflict (or executive control) effects are affected by cognitive training with a Dual n-back task. We considered three groups of young adult participants: ADHD patients without medication (ADHD), ADHD with medication (MADHD), and age/education-matched controls. Working memory training consisted of a daily practice of 20 blocks of Dual n-back task (approximately 30 min per day) for 20 days within one month. Participants of each group were randomly assigned into two subgroups, the first one with an adaptive mode of difficulty (adaptive training), while the second was blocked at the level 1 during the whole training phase (1-back task, baseline training). Alerting and orienting effects were not modified by working memory training. The dimensional analysis showed that after baseline training, the lesser the severity of the hyperactive-impulsive symptoms, the larger the improvement of reaction times on trials with high executive control/conflict demand (i.e., what is called Conflict Effect), irrespective of the participants’ group. In the categorical analysis, we observed the improvement in such Conflict Effect after the adaptive training in adult ADHD patients irrespective of their medication, but not in controls. The ex-Gaussian analysis of RT and RT variability showed that the improvement in the Conflict Effect correlated with a decrease in the proportion of extreme slow responses. The Dual n-back task in the adaptive mode offers as a promising candidate for a cognitive remediation of adult ADHD patients without pharmaceutical medication.
Intervention Using Body Shadow to Evoke Loading Imagery in a Patient with Complex Regional Pain Syndrome in the Foot: A Case Report
Authors: Hirakawa Yoshiyuki , Imai Ryota , Shigetoh Hayato , Morioka Shu
Published: October 2020

We present the case of a female patient who developed complex regional pain syndrome (CRPS) after a right-foot injury. The patient had pain from the right knee to the toes and showed severe disgust at the appearance of the affected limb. Consequently, the affected limb was not fully loaded, and the patient had difficulty walking. General interventions, such as mirror therapy, were attempted, but the effect was limited. We hypothesized that this was due to the disgust toward the affected limb, and we implemented a body-shadow intervention that we developed. This reduced the disgust for the affected limb and improved pain, but neither changed the anticipated pain of loading the affected limb nor improved the patient’s walking ability. The reason for this was considered to be that the previous interventions using the body shadow utilized the third-person perspective, denoting that the image of the load sensation on the sole of the foot during walking was insufficient; therefore, we attempted a first-person body-shadow intervention. The results showed improvement in the patient’s walking ability. In CRPS of the foot, it is important to use interventions that evoke images of loading without causing anticipatory pain, pointing to the effectiveness of body-shadow interventions.
Properties of Iron-Modified-by-Silver Supported on Mordenite as Catalysts for NOx Reduction
Authors: Sánchez-López Perla , Kotolevich Yulia , Khramov Evgeny , Chowdari Ramesh Kumar , Estrada Miguel Angel , Berlier Gloria , Zubavichus Yan , Fuentes Sergio , Petranovskii Vitalii , Chávez-Rivas Fernando
Published: October 2020

A series of mono and bimetallic catalysts based on a Fe-Ag mixture deposited on mordenite was prepared by ion-exchange and evaluated in the catalytic activity test of the de-NOx reaction in the presence of CO/C3H6. The activity results showed that the most active samples were the Fe-containing ones, and at high temperatures, a co-promoter effect of Ag on the activity of Fe catalysts was also observed. The influence of the order of cation deposition on catalysts formation and their physicochemical properties was studied by FTIR (Fourier Transform Infrared Spectroscopy) of adsorbed NO, XANES (X-ray Absorption Near-Edge Structure), and EXAFS (Extended X-ray Absorption Fine Structure) and discussed in terms of the state of iron. Results of Fe K-edge XANES oscillations showed that, in FeMOR catalysts, iron was present in a disordered state as Fe3+ and Fe2+. In FeAgMOR, the prevailing species was Fe3+, while in the AgFeMOR catalyst, the state of iron was intermediate or mixed between FeMOR and FeAgMOR. The Fe K-edge EXAFS results were characteristic of a disordered phase, the first coordination sphere being asymmetric with two different Fe-O distances. In FeAgMOR and AgFeMOR, coordination of Fe-O was similar to Fe2O3 with a few amount of Fe2+ species. We may conclude that, in the bimetallic FeAgMOR and AgFeMOR samples, a certain amount of tetrahedral Al3+ ions in the mordenite framework is replaced by Fe3+ ions, confirming the previous reports that these species are active sites for the de-NOx reaction. Based on the thermodynamic analysis and experimental data, also, it was confirmed that the order of deposition of the components influenced the mechanism of active sites’ formation during the two steps ion-exchange synthesis.
Photocatalytic Nanocomposite Materials Based on Inorganic Polymers (Geopolymers): A Review
Authors: Falah Mahroo , MacKenzie Kenneth J. D.
Published: October 2020

Geopolymers are ecologically-friendly inorganic materials which can be produced at low temperatures from industrial wastes such as fly ash, blast furnace slags or mining residues. Although to date their principal applications have been seen as alternatives to Portland cement building materials, their properties make them suitable for a number of more advanced applications, including as photocatalytic nanocomposites for removal of hazardous pollutants from waste water or the atmosphere. For this purpose, they can be combined with photocatalytic moieties such as metal oxides with suitable bandgaps to couple with UV or visible radiation, or with carbon nanotubes or graphene. In these composites the geopolymers act as supports for the photoactive components, but geopolymers formed from wastes containing oxides such as Fe2O3 show intrinsic photoactive behaviour. This review discusses the structure and formation chemistry of geopolymers and the principles required for their utilisation as photocatalysts. The literature on existing photocatalytic geopolymers is reviewed, suggesting that these materials have a promising potential as inexpensive, efficient and ecologically-friendly candidates for the remediation of toxic environmental pollutants and would repay further development.
Psychometric Analyses of the Indian (Hindi) Version of the Child Perception Questionnaire (CPQ11–14)
Authors: Tadakamadla Santosh Kumar , Mangal Garima , Quadri Mir Faeq Ali , Nayeem Maryam , Tadakamadla Jyothi
Published: October 2020

The current research aims to evaluate the reliability and validity of the Hindi Child Perception Questionnaire (CPQ11–14) in a child population of India. A randomly selected sample of children aged 11–14 years (n = 331) and their parents completed the Hindi translation of CPQ11–14 and the Parental-Caregiver Perceptions Questionnaire (P-CPQ), respectively, in this cross-sectional study. Children also provided a self-rating of oral health and were examined for dental caries. Exploratory Factor Analysis (EFA) was conducted to assess the dimensionality of the Hindi-CPQ11–14. Internal consistency and reliability on repeated administration were evaluated. Convergent and divergent validities were determined by estimating correlation coefficients between items and the hypothesised subscales. Concurrent validity was assessed using multiple linear regression analyses. The four factors extracted in EFA had a total variance of 38.5%, comprising 31 items. Cronbach’s alpha for the internal consistency of the overall scale was 0.90; reliability on repeated administration was 0.92. All the Hindi CPQ11–14 items had an item-hypothesised subscale correlation coefficient of ≥0.4, and these were greater than item-other hypothesised subscale correlations, demonstrating good convergent and divergent validities respectively. Hindi-CPQ11–14 was associated with self-ratings of the oral health and overall P-CPQ scores demonstrating good concurrent validity. Hindi-CPQ11–14 showed a factor structure different from the English CPQ11–14 and exhibited good validity and reliability.
High-Pressure Structural Behavior and Equation of State of Kagome Staircase Compound, Ni3V2O8
Authors: Diaz-Anichtchenko Daniel , Turnbull Robin , Bandiello Enrico , Anzellini Simone , Errandonea Daniel
Published: October 2020

We report on high-pressure synchrotron X-ray diffraction measurements on Ni3V2O8 at room-temperature up to 23 GPa. According to this study, the ambient-pressure orthorhombic structure remains stable up to the highest pressure reached in the experiments. We have also obtained the pressure dependence of the unit-cell parameters, which reveals an anisotropic compression behavior. In addition, a room-temperature pressure–volume third-order Birch–Murnaghan equation of state has been obtained with parameters: V0 = 555.7(2) Å3, K0 = 139(3) GPa, and K0′ = 4.4(3). According to this result, Ni3V2O8 is the least compressible kagome-type vanadate. The changes of the crystal structure under compression have been related to the presence of a chain of edge-sharing NiO6 octahedral units forming kagome staircases interconnected by VO4 rigid tetrahedral units. The reported results are discussed in comparison with high-pressure X-ray diffraction results from isostructural Zn3V2O8 and density-functional theory calculations on several isostructural vanadates.
Compressive Strength Forecasting of Air-Entrained Rubberized Concrete during the Hardening Process Utilizing Elastic Wave Method
Authors: Lim Zhi Heng , Lee Foo Wei , Mo Kim Hung , Lim Jee Hock , Yew Ming Kun , Kwong Kok Zee
Published: October 2020

Conventional compressive strength test of concrete involves the destruction of concrete samples or existing structures. Thus, the focus of this research is to ascertain a more effective method to assess the compressive strength of concrete, especially during the hardening process. One of the prevalent non-destructive test (NDT) methods that involves the employment of elastic wave has been proposed to forecast the compressive strength development of air-entrained rubberized concrete. The change of the properties, such as wave amplitude, velocity and dominant frequency of the wave that propagates within the concrete is investigated. These wave parameters are then correlated with the compressive strength data, obtained using the conventional compressive strength test. It has been certified that both correlation between wave amplitude and concrete compressive strength, as well as the correlation between velocity and concrete compressive strength, have high regression degrees, which are 0.9404 and 0.8788, respectively. On the contrary, dominant wave frequency has been proved imprecise to be used to correlate with the concrete compressive strength development, as a low correlation coefficient of 0.2677 is reported. In a nutshell, the correlation data of wave amplitude and velocity could be used to forecast the compressive strength development of an air-entrained rubberized concrete in the future.
Vertical Alignment of Nematic Liquid Crystals Based on Spontaneous Alignment Layer Formation between Silver Nanowire Networks and Nonionic Amphiphiles
Authors: Son Seung-Rak , Lee Jun Hyup
Published: October 2020

The vertical arrangement of nematic liquid crystals (LCs) in displays can be generally achieved by introducing a polyimide material onto indium tin oxide electrodes. However, this method requires multiple coating and deposition processes as well as high curing temperature, restricting the potential applicability to flexible displays. Thus, we herein propose the facile approach for homeotropic alignment of nematic LCs based on spontaneous alignment layer formation between silver nanowire networks and nonionic amphiphiles. The silver nanowires as transparent electrode materials were spin-coated on glass substrate and 4-(4-heptylphenyl)benzoic acids as nonionic amphiphiles were doped into the LC medium. The nonionic amphiphiles were spontaneously bonded to the polyvinylpyrrolidone capping layer of silver nanowire networks through polar interactions, creating the self-assembled alignment layer of nonionic amphiphiles on silver nanowire electrodes. In addition, the alkyl chains of the amphiphiles interacted with the LC molecules, leading to stable directional LC alignment along vertical direction. The electro-optical characteristics of the manufactured LC cell were comparable to those of conventional device including polyimide layer and indium tin oxide electrode. Overall, the combination of silver nanowire electrode and nonionic amphiphiles presents a new way to achieve the vertical alignment of nematic LCs without polyimide layer.
Surface Charge Properties of Marble Powder and its Effect on the Formation of Hydrates in Cement Paste
Authors: Ouyang Xiaowei , Xu Shida , Wang Liquan , Huang Jianzhang
Published: October 2020

Replacing part of cement with waste stone powder can reduce the use of cement, thus reducing energy consumption and CO2 emission. Different stone powders affect the properties of cement-based materials differently. It is important to clarify the effect of the surface properties of the stone powder on the properties of cement-based materials. In this paper, the charge properties of marble powder and its effect on the formation of hydrates were investigated. Zeta potential was used to study the charge properties of the marble surface. Parallelly, the morphology of hydrates on the surface of the cement and marble particles at a very early hydration age was observed by using SEM. Finally, the influence of the surface charge properties of the marble particles on the formation of hydration products of cement was discussed. The results showed that the marble particles have specific adsorption of Ca2+ (chemical adsorption). Therefore, the marble particles in the simulated solution can adsorb a large amount of Ca2+, thus achieving a high potential value and facilitating the formation of hydrates on their surface. However, the adsorption of Ca2+ towards the surface of the cement particle is driven by a relatively weak electrostatic force. Compared with the marble particles, less Ca2+ ions are adsorbed, and thus, fewer hydrates are formed on the surface of cement particles.
Proposal of an Alternative to the AMA Guidelines for the Evaluation of the Cervical ROM
Authors: Martínez-Beltrán María Jesus , Fidalgo-Herrera Alberto , Moreno-Ruiz José A. , de la Torre-Montero Julio C.
Published: October 2020

The cervical spine is one of the most frequently injured joints in a car accident. References for the range of motion (ROM) that should be expected in a person are needed to stage the injuries. The two main objectives of this paper are to clinically validate a measuring device for the cervical spine, and to assess if the use of different ROM reference values will render different results from the American Medical Association (AMA) ROM guidelines. The present study is divided into 2 phases, a validation phase with 55 subjects and a case-control phase with 80 subjects. A BTS (Bioengineering Technology and System) system and the EBI-5 (estudio biomecánico integral) system were used for the present investigation. The intraclass correlation agreement value between both measuring devices is considered very good with a Cronbach alpha up to 0.9 in every dimension. Correlations (r) between variables are very high, not showing any values lower than 0.887. All comparisons between using AMA ROM guidelines or normative values presented significant differences (p < 0.05). The EBI-5 system has exhibited good accuracy being paired to a photogrammetric system. The use of guidelines adjusted to age constitute an alternative to the use of the AMA cervical ROM guidelines. Professionals should use age-normalized guidelines as an alternative to the AMA guidelines.
Automatic Assessment of ASPECTS Using Diffusion-Weighted Imaging in Acute Ischemic Stroke Using Recurrent Residual Convolutional Neural Network
Authors: Do Luu-Ngoc , Baek Byung Hyun , Kim Seul Kee , Yang Hyung-Jeong , Park Ilwoo , Yoon Woong
Published: October 2020

The early detection and rapid quantification of acute ischemic lesions play pivotal roles in stroke management. We developed a deep learning algorithm for the automatic binary classification of the Alberta Stroke Program Early Computed Tomographic Score (ASPECTS) using diffusion-weighted imaging (DWI) in acute stroke patients. Three hundred and ninety DWI datasets with acute anterior circulation stroke were included. A classifier algorithm utilizing a recurrent residual convolutional neural network (RRCNN) was developed for classification between low (1–6) and high (7–10) DWI-ASPECTS groups. The model performance was compared with a pre-trained VGG16, Inception V3, and a 3D convolutional neural network (3DCNN). The proposed RRCNN model demonstrated higher performance than the pre-trained models and 3DCNN with an accuracy of 87.3%, AUC of 0.941, and F1-score of 0.888 for classification between the low and high DWI-ASPECTS groups. These results suggest that the deep learning algorithm developed in this study can provide a rapid assessment of DWI-ASPECTS and may serve as an ancillary tool that can assist physicians in making urgent clinical decisions.
An Evaluation of the Drone Delivery of Adrenaline Auto-Injectors for Anaphylaxis: Pharmacists’ Perceptions, Acceptance, and Concerns
Authors: Beck September , Bui Tam , Davies Andrew , Courtney Patrick , Brown Alex , Geudens Jef , Royall Paul
Published: October 2020

Anaphylaxis is a life-threatening condition where delays in medical treatment can be fatal. Such situations would benefit from the drone delivery of an adrenaline auto-injector such as EpiPen®. This study evaluates the potential risk, reward, and impact of drone transportation on the stability of adrenaline during episodes of anaphylaxis. Further, this study examines pharmacists’ perceptions on drone delivery—pharmacists approved the use of drones to deliver EpiPen® during emergencies but had concerns with drone safety and supply chain security. Laboratory simulated onboard drone conditions reflected typical missions. In these experiments, in vitro model and pharmaceutical equivalent formulations were subjected independently to 30 min vibrations at 5, 8.43, and 13.33 Hz, and temperature storage at 4, 25, 40, and 65 °C for 0, 0.5, 3, and 24 h. The chiral composition (an indicator of chemical purity that relates to molecular structure) and concentration of these adrenaline formulations were determined using ultraviolet (UV) and circular dichroism spectroscopy (CD). Adrenaline intrinsic stability was also explored by edge-of-failure experimentation to signpost the uppermost limits for safe transportation. During drone flight with EpiPen®, the temperature and vibration g-force were 10.7 °C and 1.8 g, respectively. No adverse impact on adrenaline was observed during drone flight and laboratory-simulated conditions shown by conformation to the British Pharmacopeia standards (p > 0.05 for CD and UV). This study showed that drone delivery of EpiPen® is feasible. There are more than 15,000 community pharmacies and ≈9000 GP surgeries spanning the UK, which are likely to provide achievable ranges and distances for the direct drone delivery of EpiPen®. The authors recommend that when designing future missions, in addition to medicine stability testing that models the stresses imposed by drone flight, one must conduct a perceptions survey on the relevant group of medical professionals, because their insights, acceptance, and concerns are extremely valuable for the design and evaluation of the mission.
Education and Care: How Teachers Promote the Inclusion of Children and Youth at Risk in South Africa
Authors: Balie Lorna , Sayed Yusuf
Published: October 2020

Children and youth at risk, particularly those placed in child and youth care centres (CYCC) in South Africa, have suffered from school disengagement due to multiple barriers to learning such as the exposure to crime and violence at a young age. As children and youth at risk at these centres find it difficult to engage in learning, new approaches need to be found to re-engage their interest to learn. This article discusses how the ‘Curriculum of Care’, an adaptation of the Curriculum and Assessment Policy Statement (CAPS), responds to the educational needs of children and youth at risk at a CYCC in the Western Cape. It draws primarily from interviews and a focus group discussion with the centre manager and teachers at the institution. The findings reveal that positive learning outcomes, and the effective integration of children and youth at risk, are shaped by positive teacher–learner relationships; however, the findings raise questions about the extent to which such a curriculum prepares children and youth at risk for life after they leave the institution. The article suggests that the institutions providing education and care for children and youth at risk need to provide a curriculum balancing academic rigour with care to promote a holistic, inclusive education programme that enables youth and children at risk to effectively navigate their entry into society.
A Contemplation on Electricity Meters In-Service Surveillance Assisted by Remote Error Monitoring
Authors: Nakutis Žilvinas , Kaškonas Paulius
Published: October 2020

In this paper, remote error monitoring techniques for electricity meters are overviewed suggesting their utilization for in-service surveillance assistance. It is discussed that in-service error observation could provide valuable input, contributing to the timely detection of batches of meters reaching nonconformance status. The payback period analysis of the deployment of a remote error monitoring solution is considered. However, it is pointed out that such an analysis lacks input information describing the relationship between the remote monitoring system’s performance and its ability to detect nonconformance of the batch. It is also noticed that there is no published methodology for grading the status of an entire batch of meters referring to error estimates of a subset of the meters, when the uncertainty of estimation is rather high.
Assessment of the Lowland Bog Biomass for Ex Situ Remediation of Petroleum-Contaminated Soils
Authors: Tarabukin Dmitriy V.
Published: October 2020

Bog petroleum-contaminated soils have been remediated ex situ in conditions close to natural ones. It was found that during the first 30 days in natural conditions, the decomposition of total petroleum hydrocarbons (TPH) was 30 ± 5%. On the 60th and 90th days, the process of TPH decomposition was 45 ± 5% and 60 ± 5%, respectively. The effect of various stimulant supplements was negligible. For the entire observed period, bog soil showed a very high self-cleaning potential with pollution concentration of 5 g of petroleum per 100 g of soil sample. Such diagnostic indicators of soil condition as urease and cellulase activities turned out to be most sensitive in the bog soil. The introduction of mineral fertilizers to stimulate the TPH decomposition increased the activity of urease in comparison with the background soil. On the other hand, the nonionic surfactant acted as an inhibitor of microorganisms involved in nitrogen metabolism, even in the presence of mineral fertilizers. The introduction of mineral fertilizers to petroleum-polluted bog soil stimulated the cellulases activity, while surfactants suppressed them in the early stages. The simultaneous introduction of surfactants and fertilizers kept the cellulase activity at the background level. It is concluded that in the case of petroleum pollution of infertile soils, the introduction of the upper layers of the phytomass of lowland bogs by providing looseness and long-term supply of nutrients from the dying parts of the moss will accelerate the self-cleaning processes.
Reconstruction of Piñon–Juniper Woodlands in the Sky Islands of the Davis Mountains, Texas, USA
Authors: Bataineh Mohammad M. , Oswald Brian P. , Williams Hans M. , Unger Daniel R. , Hung I-Kuai
Published: October 2020

Piñon (Pinus spp. L.)–juniper (Juniperus spp. L.) woodlands’ historical stand structures were recreated to provide reference conditions and document long-term changes in the Sky Islands of the Davis Mountains, Texas. Restoration of these isolated woodlands requires insights into the range of variability in current and historical stand structures, as well as an understanding of the spatiotemporal establishment and recruitment patterns of tree species. With drastic changes in forests and woodlands of the Southwestern United States widely reported, the main objective of this study was to reconstruct woodland tree temporal and spatial establishment patterns. A stratified random sampling approach was used to select two study sites each of 3600 m2 in area. Within each site, all individual trees were mapped, measured, and cored for age determination. Age and tree location data were used to recreate the spatiotemporal patterns of tree species establishment and recruitment. Increments in density of both Mexican piñon (Pinus cembroides var. cembroides Zucc.) and alligator juniper (Juniperus deppeana var. deppeana Steud.) reached 422 trees ha−1 in the 115-year period between 1890 and 2005; a yearly increment of 4 trees ha−1 that did not reflect a rapid rate of change in these piñon–juniper woodlands. Age distributions reflected the multi-cohort nature of these woodlands, and spatial autocorrelation measures were useful in the objective delineation of these cohorts. Temporal and functional niche differentiation of juniper was reflected in the development pattern where alligator juniper served as a pioneer species, exhibited a longer period of substantial recruitment, and had greater recruitment rates than that of Mexican piñon. Recruitment of Mexican piñon and alligator juniper occurred in an episodic fashion, with the majority of recruits being acquired between 1890 and 1949.
Bacterial Canker Disease on Populus × euramericana Caused by Lonsdalea populi in Serbia
Authors: Zlatković Milica , Tenorio-Baigorria Imola , Lakatos Tamás , Tóth Tímea , Koltay András , Pap Predrag , Marković Miroslav , Orlović Saša
Published: October 2020

Populus × euramericana (Dode) Guinier clone (cl.) “I-214” is a fast-growing interspecific hybrid between Eastern cottonwood (P. deltoides Bartr. ex Marsh) and European black poplar (Populus nigra L.). Populus × euramericana was introduced into Serbia in the 1950s and has become one of the most widely grown poplar species. In September 2019, cankers were observed on stems and branches of P. × euramericana cl. “I-214” trees in a two-year-old poplar plantation in the province of Vojvodina, Serbia. The canker tissue was soft and watery, and a colorless fluid that smelled rotten flowed from the cracks in the bark, suggesting possible bacterial disease. After two weeks, diseased trees experienced crown die-back and oozing of foamy, odorous exudates and this study aimed to identify the causal agent of the disease. Canker margins and exudates were collected from 20 symptomatic trees. The associated bacterium was isolated and identified using biochemical characteristics, phylogenetic analyses based on 16S rRNA gene sequences, and multilocus sequence analyses (MLSA) based on partial sequencing of three housekeeping genes (gyrB, infB, and atpD). The pathogen was identified as Lonsdalea populi. Pathogenicity tests were conducted on rooted cuttings of P. × euramericana cl. “I-214” in an environmental test chamber and demonstrated that the isolated bacterial strain was able to reproduce symptoms of softened, water-soaked cankers and exudation. To the best of our knowledge, this is the first report of L. populi causing bacterial canker disease on P. × euramericana cl. “I-214” in Serbia and in southeastern Europe (SEE). It is also the first report of a bacterial disease on hybrid poplars, including P. × euramericana in this country and in SEE. If the disease spreads into new areas, selection for L. populi resistance may need to be integrated into future poplar breeding programs.
Rockfall Research: A Bibliometric Analysis and Future Trends
Authors: Briones-Bitar Josué , Carrión-Mero Paúl , Montalván-Burbano Néstor , Morante-Carballo Fernando
Published: October 2020

Rockfall is one of the main phenomena in mountainous environments due to its fast and high speed of movement, its unpredictability, and, therefore, the difficulty of identifying signs of instability and detachment of the blocks. Compared to other types of sliding, the proportion of rockfall research is smaller and sometimes little known, but, in the last five years, rapid growth in this area has been shown. Therefore, this research aimed to review the intellectual structure of rockfall, through analysis of scientific production using bibliometric techniques that allow its analysis, knowledge, global evolution, and future trends in rockfall. The research methodology consists of three steps: (1) data compilation, (2) software and data cleaning, and (3) analysis, interpretation, and visualization. This analysis focuses on the period from 1975 to 2019. For the data, a total of 811 academic publications were retrieved from the Scopus database. The results indicate an increasing trend of annual publications on rockfall. This analysis reveals the main topics, countries, and most influential institutions in the world that have carried out relevant research in scientific publications; it also shows the journals that have the most publications. VOSviewer software was adopted to evaluate the co-occurrence of author keywords. Currently, the hotspots rockfall issues mainly include: hazard-risk assessment, remote sensing, and rockfall monitoring. Finally, this article analyzes the limitations of current research and proposes a future direction for the development of new research.
Variations in Rates of Discharges to Nursing Homes after Acute Hospitalization for Stroke and the Influence of Service Heterogeneity: An Anglia Stroke Clinical Network Evaluation Study
Authors: Tørnes Michelle , McLernon David , Bachmann Max O , Musgrave Stanley D , Day Diana J , Warburton Elizabeth A , Potter John F , Myint Phyo Kyaw
Published: October 2020

Nursing home placement after stroke indicates a poor outcome but numbers placed vary between hospitals. The aim of this study is to determine whether between-hospital variations in new nursing home placements post-stroke are reliant solely on case-mix differences or whether service heterogeneity plays a role. A prospective, multi-center cohort study of acute stroke patients admitted to eight National Health Service acute hospitals within the Anglia Stroke and Heart Clinical Network between 2009 and 2011 was conducted. We modeled the association between hospitals (as a fixed-effect) and rates of new discharges to nursing homes using multiple logistic regression, adjusting for important patient risk factors. Descriptive and graphical data analyses were undertaken to explore the role of hospital characteristics. Of 1335 stroke admissions, 135 (10%) were discharged to a nursing home but rates varied considerably from 6% to 19% between hospitals. The hospital with the highest adjusted odds ratio of nursing home discharges (OR 4.26; 95% CI 1.69 to 10.73), was the only hospital that did not provide rehabilitation beds in the stroke unit. Increasing hospital size appeared to be related to an increased odds of nursing home placement, although attenuated by the number of hospital stroke admissions. Our results highlight the potential influence of hospital characteristics on this important outcome, independently of patient-level factors.
Partitioning of Rainfall and Sprinkler-Irrigation by Crop Canopies: A Global Review and Evaluation of Available Research
Authors: Lin Meimei , Sadeghi Seyed Mohammad Moein , Van Stan John T.
Published: October 2020

The role of crop canopies in the global water cycle is a topic of increasing international interest. How much rain and sprinkler-irrigation water are returned to the atmosphere or reach the soils beneath crop canopies, and the pathways of those water inputs at the soil, are linked to agricultural productivity and sustainability. This concise-format review synthesized and evaluated the available, limited, observational data (138 studies) on cropland throughfall, stemflow, and/or interception for >60 crop species covering all major climate types to obtain a global analysis of rainfall and sprinkler-irrigation partitioning by crop canopies. Partitions normalized per unit rain/sprinkler-irrigation (relative fractions, %) vary greatly across crop types with the interquartile range of throughfall, stemflow, and interception being 58–83%, 2–26%, and 11–32%, respectively. Stemflow data distribution across crop types is more often different than for throughfall and interception, contributing to overall variations in the partitioning of rain and irrigation observed to date. Partitions per storm also differ depending on the magnitude of rain or sprinkler-irrigation events and the stage of crop growth. Furthermore, throughfall and stemflow input patterns at the soil surface and subsurface may erode soils through different physical processes (i.e., throughfall droplet impact/splash versus scouring by stemflow); however, more research is needed to elucidate the underlying mechanisms and overall impacts. Finally, comparative analyses of partitions among croplands, shrublands, and forests indicate that crop canopies partition rain inputs differently and that there is a lack of studies in croplands. Hence, we suggest that future effort should be directed to the partitioning of rainfall and sprinkler-irrigation by canopies in agricultural settings.
Gingival Crevicular Blood as a Potential Screening Tool: A Cross Sectional Comparative Study
Authors: Rapone Biagio , Ferrara Elisabetta , Santacroce Luigi , Topi Skender , Converti Ilaria , Gnoni Antonio , Scarano Antonio , Scacco Salvatore
Published: October 2020

Background: Diabetes is known to be one of the major global epidemic diseases, significantly associated with mortality and morbidity worldwide, conferring a substantial burden to the health care system. The epidemiological transition of this chronic disease tends to worsen unless preventive health strategies are implemented. Appropriate screening devices and standardized methods are crucial to prevent this potentially inauspicious life condition. Currently, the glucometer is the conventional device employed for blood glucose level determination that outputs the blood glucose reading. Glucometer performed in the dental office may be an important device in screening diabetes, so it can be addressed during a periodontal examination. Because gingival blood is a useful source to detect the glucose level, the focus is placed on the opportunity that might provide valuable diagnostic information. This study aimed to compare gingival crevicular blood with finger-stick blood glucose measurements using a self-monitoring glucometer, to evaluate whether gingival crevicular blood could be an alternative to allow accurate chairside glucose testing. Methods: A cross-sectional comparative study was performed among a 31–67-year-old population. Seventy participants with diagnosed type 2 diabetes and seventy healthy subjects, all with positive bleeding on probing, were enrolled. The gingival crevicular blood was collected using a glucometer to estimate the blood glucose level and compared with finger-stick blood glucose level. Results: The mean capillary blood glucose and gingival crevicular blood levels from all samples were, respectively, 160.42 ± 31.31 mg/dL and 161.64 ± 31.56 mg/dL for diabetic participants and 93.51 ± 10.35 mg/dL and 94.47 ± 9.91 mg/dL for healthy patients. In both groups, the difference between gingival crevicular blood and capillary blood glucose levels was non-significant (P < 0.05). The highly significant correlation between capillary blood glucose and gingival crevicular blood (r = 0.9834 for diabetic patients and r = 0.8153 for healthy participants) in both the groups was found. Conclusions: Gingival crevicular blood test was demonstrated as a feasible and useful primary screening tool test for detecting diabetes and for glucose estimation in non-diabetic patients. Use of gingival crevicular blood for screening is an attractive way of identifying a reasonable option of finger-stick blood glucose measurement under the appropriate circumstances. Rapid assessment may precede diagnostic evaluation in diabetic as well as healthy patients with acute severe bleeding. In addition, gingival crevicular blood levels may be needed to monitor the diabetic output.
Integrated Impact Assessment of Active Travel: Expanding the Scope of the Health Economic Assessment Tool (HEAT) for Walking and Cycling
Authors: Götschi Thomas , Kahlmeier Sonja , Castro Alberto , Brand Christian , Cavill Nick , Kelly Paul , Lieb Christoph , Rojas-Rueda David , Woodcock James , Racioppi Francesca
Published: October 2020

The World Health Organization’s Health Economic Assessment Tool (HEAT) for walking and cycling is a user-friendly web-based tool to assess the health impacts of active travel. HEAT, developed over 10 years ago, has been used by researchers, planners and policymakers alike in appraisals of walking and cycling policies at both national and more local scales. HEAT has undergone regular upgrades adopting the latest scientific evidence. This article presents the most recent upgrades of the tool. The health impacts of walking and/or cycling in a specified population are quantified in terms of premature deaths avoided (or caused). In addition to the calculation of benefits derived from physical activity, HEAT was recently expanded to include assessments of the burden associated with air pollution exposure and crash risks while walking or cycling. Further, the impacts on carbon emissions from mode shifts to active travel modes can now be assessed. The monetization of impacts using Value of Statistical Life and Social Costs of Carbon now uses country-specific values. As active travel inherently results in often substantial health benefits as well as not always negligible risks, assessments of active travel behavior or policies are incomplete without considering health implications. The recent developments of HEAT make it easier than ever to obtain ballpark estimates of health impacts and carbon emissions related to walking and cycling.
The Hospitality Industry in the Face of the COVID-19 Pandemic: Current Topics and Research Methods
Authors: Davahli Mohammad Reza , Karwowski Waldemar , Sonmez Sevil , Apostolopoulos Yorghos
Published: October 2020

This study reports on a systematic review of the published literature used to reveal the current research investigating the hospitality industry in the face of the COVID-19 pandemic. The presented review identified relevant papers using Google Scholar, Web of Science, and Science Direct databases. Of the 175 articles found, 50 papers met the predefined inclusion criteria. The included papers were classified concerning the following dimensions: the source of publication, hospitality industry domain, and methodology. The reviewed articles focused on different aspects of the hospitality industry, including hospitality workers’ issues, loss of jobs, revenue impact, the COVID-19 spreading patterns in the industry, market demand, prospects for recovery of the hospitality industry, safety and health, travel behavior, and preference of customers. The results revealed a variety of research approaches that have been used to investigate the hospitality industry at the time of the pandemic. The reported approaches include simulation and scenario modeling for discovering the COVID-19 spreading patterns, field surveys, secondary data analysis, discussing the resumption of activities during and after the pandemic, comparing the COVID-19 pandemic with previous public health crises, and measuring the impact of the pandemic in terms of economics.
A Meta-Analysis on the Effects of Therapeutic Recreation Programs for the Elderly
Authors: Kim Eui Jae , Kang Hyun Wook , Park Seong Man
Published: October 2020

This study gathered previous research on the effects of therapeutic recreation programs for the elderly conducted in Korea in order to investigate the average effect size as well as the factors that influence the effect sizes. This study connoted findings of individual studies related to therapeutic recreation programs for the elderly from 2000 to 2018. A total of 15 papers were selected for meta-analysis. To analyze the data, a comprehensive meta-analysis 2.0 software program was used. Firstly, the overall mean effect size of the therapeutic recreation programs for the elderly was 0.644, and it was medium size. Secondly, for each dependent variable, the mean effect size on social emotional domain was 0.739, the mean effect size on physical domain was 0.548, and the mean effect size on cognitive domain was 0.485. Thirdly, major factors that influence the effect of therapeutic recreation programs for the elderly appeared to be the program period and hours per session. The results of this study prove that therapeutic recreation programs for the elderly can be an effective way to bring along a positive change, and show that the program period and hours per session are crucial factors in the design of therapeutic recreation programs for the elderly.
Individual Capital Structure and Health Behaviors among Chinese Middle-Aged and Older Adults: A Cross-Sectional Analysis Using Bourdieu’s Theory of Capitals
Authors: Xu Peng , Jiang Junfeng
Published: October 2020

This study draws on Bourdieu’s theory of capitals to analyze the relative importance of economic, cultural, and social capital on health behaviors in Chinese middle-aged and older adults. Based on data from the China Family Panel Studies of 2016 (N = 15,147), we first harnessed a binary logistic regression model to discuss the associations between the three capitals and four types of health behaviors (i.e., physical exercise, smoking, binge drinking and stay-up). Using the sheaf coefficients technique, we then compared the relative effects of three of the capitals on health behaviors. The results suggest that cultural capital is the most influential one, which would significantly increase physical exercise and stay-up behaviors, and reduce smoking and binge drinking behaviors. Economic capital is also an important predictor, that may reduce smoking behavior but increase binge drinking and stay-up behaviors. Social capital has shown the least importance, although it would still be saliently associated with physical exercise, smoking and stay-up behaviors. In addition, some significant group disparities are also identified. This article is one of the first to explain health behavior inequalities through a Bourdieusian capital-based approach in Chinese contexts.
Does Masticatory Ability Contribute to Nutritional Status in Older Individuals?
Authors: Fujimoto Keiko , Suito Hideki , Nagao Kan , Ichikawa Tetsuo
Published: October 2020

Mastication plays a primary role in the process of eating. Hence, compromised masticatory ability may affect the nutrition and quality of life, which are particularly important concerns among older individuals. It remains unclear how is the masticatory ability assessed regarding the nutritional status. We examined the effect of various oral factors on three masticatory ability tests conducted among older individuals. A total of 100 older individuals were enrolled in this study. Body mass index (BMI) as an indicator of nutritional status; and age, sex, and the number of occlusal and molar occlusal supports as clinical attributes were recorded. Three masticatory ability tests (masticatory efficiency, masticatory score, and satisfaction with mastication) were conducted, and tongue pressure, cheek pressure, and occlusal force were assessed as oral functions. A significant but weak correlation was found between masticatory efficiency and the masticatory score, but not between masticatory efficiency and satisfaction score. Objective masticatory efficiency was strongly associated with objective oral factors, whereas subjective assessments of masticatory ability (masticatory score and satisfaction score) were not. Furthermore, BMI was significantly associated with subjective assessments of masticatory ability but not with objective masticatory efficiency. Both subjective and objective assessments of masticatory ability, along with considerations of nutritional formulations, are required for the maintenance and improvement of nutritional status in older individuals.
The Effects of Upper-Body Exoskeletons on Human Metabolic Cost and Thermal Response during Work Tasks—A Systematic Review
Authors: Del Ferraro Simona , Falcone Tiziana , Ranavolo Alberto , Molinaro Vincenzo
Published: October 2020

Background: New wearable assistive devices (exoskeletons) have been developed for assisting people during work activity or rehabilitation. Although exoskeletons have been introduced into different occupational fields in an attempt to reduce the risk of work-related musculoskeletal disorders, the effectiveness of their use in workplaces still needs to be investigated. This systematic review focused on the effects of upper-body exoskeletons (UBEs) on human metabolic cost and thermophysiological response during upper-body work tasks. Methods: articles published until 22 September 2020 were selected from Scopus, Web of Science, and PubMed for eligibility and the potential risk of bias was assessed. Results: Nine articles resulted in being eligible for the metabolic aspects, and none for the thermal analysis. All the studies were based on comparisons between conditions with and without exoskeletons and considered a total of 94 participants (mainly males) performing tasks involving the trunk or overhead work, 7 back-support exoskeletons, and 1 upper-limb support exoskeleton. Eight studies found a significant reduction in the mean values of the metabolic or cardiorespiratory parameters considered and one found no differences. Conclusions: The reduction found represents a preliminary finding that needs to be confirmed in a wider range of conditions, especially in workplaces, where work tasks show different characteristics and durations compared to those simulated in the laboratory. Future developments should investigate the dependence of metabolic cost on specific UBE design approaches during tasks involving the trunk and the possible statistical correlation between the metabolic cost and the surface ElectroMyoGraphy (sEMG) parameters. Finally, it could be interesting to investigate the effect of exoskeletons on the human thermophysiological response.