bluuebunny/crossref_metadata_2025 huggingface dataset:
Atmospheric rivers over eastern US affected by Pacific/North America pattern
Authors: Dong Wenhao , Zhao Ming , Tan Zhihong , Ramaswamy V.
Published: January 2024

Atmospheric rivers (ARs) play important roles in various extreme weather events across the US. While AR features in western US have been extensively studied, there remains limited understanding of their variability in the eastern US (EUS). Using both observations and a state-of-the-art climate model, we find a significant increase (~10% dec
−1
) in winter AR frequency in the EUS during the past four decades. This trend is closely linked to recent changes in the Pacific/North America (PNA) teleconnection pattern, accompanied by a poleward shift of the mid-latitude jet stream. We further reveal a strong correlation (
R
= 0.8;
P
< 0.001) between interannual variations in AR occurrence and the PNA index. This linkage has been verified in various model simulations. A statistical model, built on this linkage, has proven effective in predicting the AR frequency using the PNA index at both monthly and seasonal scales. These promising results have important implications for addressing concerns related to AR-associated extreme precipitation and flooding in this region.
Erratum to: Are the Goals of Therapy Achievable in Patients with Rheumatoid Arthritis Receiving Upadacitinib in Real Clinical Practice?
Authors: Amirdzhanova V. N. , Karateev A. E. , Pogozheva E. Yu. , Filatova E. S. , Samigullina R. R. , Mazurov V. I. , Anoshenkova O. N. , Lapkina N. A. , Baranov A. A. , Grineva T. Yu. , Lila A. M. , Nasonov E. L.
Published: January 2024

An Erratum to this paper has been published: https://doi.org/10.1134/S1607672923050010
Erratum to: Different Clinical Relevance of Anti-Citrullinated Protein Antibodies in RA Patients
Authors: Avdeeva A. S. , Cherkasova M. V. , Nasonov E. L.
Published: January 2024

An Erratum to this paper has been published: https://doi.org/10.1134/S1607672923050034
Erratum to: Global Antiphospholipid Syndrome Score (GAPSS) in Patients with Systemic Lupus Erythematosus
Authors: Cheldieva F. A. , Reshetnyak T. M. , Shumilova A. A. , Nurbaeva K. S. , Cherkasova M. V. , Lila A. M. , Nasonov E. L.
Published: January 2024

An Erratum to this paper has been published: https://doi.org/10.1134/S1607672923050046
Erratum to: Comparative Pharmacoeconomic Effectiveness of Interleukin-17 Inhibitors for the Treatment of Ankylosing Spondylitis
Authors: Dubinina T. V. , Gaidukova I. Z. , Sableva N. A. , Sapozhnikov K. V. , Sokolova V. D. , Tolkacheva D. G.
Published: January 2024

An Erratum to this paper has been published: https://doi.org/10.1134/S1607672923050058
Erratum to: Structure Analysis of the MatA Locus of Sexual Compatibility in the Edible Mushroom Pleurotus ostreatus
Authors: Shnyreva A. V. , Shnyreva A. A.
Published: January 2024

An Erratum to this paper has been published: https://doi.org/10.1134/S1607672923050071
Erratum to: Synthetic Peptide Fragments of the Wtx Toxin Reduce Blood Pressure in Rats under General Anesthesia
Authors: Severyukhina M. S. , Ismailova A. M. , Shaykhutdinova E. R. , Dyachenko I. A. , Egorova N. S. , Murashev A. N. , Tsetlin V. I. , Utkin Yu. N.
Published: January 2024

An Erratum to this paper has been published: https://doi.org/10.1134/S1607672923050095
Image Super-Resolution Reconstruction Model Based on Multi-Feature Fusion
Authors: Dai Zemiao
Published: January 2024

Due to the limitations of imaging equipment and image transmission conditions on daily image acquisition, the images acquired are usually low-resolution images, and it will cost a lot of time and economic costs to increase image resolution by upgrading hardware equipment. In this paper, we propose an image super-resolution reconstruction algorithm based on spatio-temporal-dependent residual network MSRN, which fuses multiple features. The algorithm uses the surface feature extraction module to extract the input features of the image, and then uses the deep residual aggregation module to adaptively learn the deep features, and then fuses multiple features and learns the global residual. Finally, the high-resolution image is obtained through the up-sampling module and the reconstruction module. In the model structure, different convolution kernels and jump connections are used to extract more high-frequency information, and spatio-temporal attention mechanism is introduced to focus on more image details. The experimental results show that compared with SRGAN, VDSR and Laplacian Pyramid SRN, the proposed algorithm finally achieves better reconstruction effect, and the image texture details are clearer under different scaling factors. In objective evaluation, the peak signal-to-noise ratio (PSNR) and structure similarity (SSIM) of the proposed algorithm are improved compared with SRGAN.
Compact Spice Models for Terafets
Authors: Liu Xueqing , Ytterdal Trond , Shur Michael
Published: January 2024

Field effect transistors (FETs) in plasmonic regimes of operation could detect terahertz (THz) radiation and operate as THz interferometers, spectrometers, frequency-to-digital converters and THz modulators and sources. We report on the development of compact models for Si MOS (Metal-Oxide-semiconductor) and heterostructure-based plasmonic FETs (or TeraFETs) suitable for circuit design in the THz range and based on the multi-segment unified charge control model. This model accounts for the electron inertia effect (by incorporating segmented Drude inductances), for the ballistic field effect mobility, which is proportional to the channel length, for parasitic resistances and capacitances and for the leakage current. It is validated by comparison with experimental data and TCAD simulation results. The model can be used for simulation and optimization of sub-THz and THz detectors. Our simulations use up to 200 segments in the device channel. The results are also in good qualitative agreement with the hydrodynamic simulations. Applications of our model could dramatically reduce astronomical design costs of nanoscale VLSI reaching US$1.5 billion for the 3 nm technological node.
Influence of Finite Diffusion on Cation Insertion-Coupled Electron Transfer Kinetics in Thin Film Electrodes
Authors: Chagnot Matthew , Abello Sofia , Wang Ruocun , Dawlaty Jahan , Rodríguez-López Joaquín , Zhang Chao , Augustyn Veronica
Published: January 2024

Materials that undergo ion-insertion coupled electron transfer are important for energy storage, energy conversion, and optoelectronics applications. Cyclic voltammetry is a powerful technique to understand electrochemical kinetics. However, the interpretation of the kinetic behavior of ion insertion electrodes with analytical solutions developed for ion blocking electrodes has led to confusion about their rate-limiting behavior. The purpose of this manuscript is to demonstrate that the cyclic voltammetry response of thin film electrode materials undergoing solid-solution ion insertion without significant Ohmic polarization can be explained by well-established models for finite diffusion. To do this, we utilize an experimental and simulation approach to understand the kinetics of Li+ insertion-coupled electron transfer into a thin film material (Nb2O5). We demonstrate general trends for the peak current vs scan rate behavior, with the latter parameter elevated to an exponent between limiting values of 1 and 0.5, depending on the solid-state diffusion characteristics of the film (diffusion coefficient, film thickness) and the experiment timescale (scan rate). We also show that values < 0.5 are possible depending on the cathodic potential limit. Our results will be useful to fundamentally understand and guide the selection and design of intercalation materials for multiple applications.
Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study
Authors: Gao Li , Yan Shi-Bai , Jiang Fang-Cheng , Huang Zhi-Guang , Li Dong-Ming , Tang Yu-Lu , Luo Jia-Yuan , Chen Gang , Wei Dan-Ming
Published: January 2024

Aim. To investigate the specific expression profile, clinicopathological significance and mechanism of Zic family member 2 (ZIC2) in oral cancer were unclear. Patients and Methods. We explored the expression pattern and clinicopathological significance of ZIC2 in oral cancer through performing in-house tissue microarray and integrated analysis global RNA-seq and microarrays containing large samples. The molecular basis of ZIC2 in oral cancer was further investigated in the aspects of transcription network and immune correlations. We also performed in vitro experiments and calculated drug sensitivity of oral cancer with different ZIC2 expression levels in response to hundreds of compounds. Results. All data unanimously proved the significant overexpression of ZIC2 in oral cancer. The upregulation of ZIC2 was remarkably associated with the malignant clinical progression of oral cancer. ZIC2 was predicted to be targeted by miRNAs such as miR-3140, miR-4999, and miR-1322. The infiltration level of CD8+ T and central memory cells was positively related to the overexpression of ZIC2. Oral cancer patients with higher ZIC2 expression showed higher drug sensitivity to two compounds including AZD8186 and ERK_2240. Conclusions. We demonstrated the upregulation of ZIC2 in oral cancer and its promoting effect on the clinical advancement of oral cancer. The potential clinical value of ZIC2 in oral cancer deserves attention.
A Virtual Fabrication and High-Performance Design of 65 nm Nanocrystal Floating-Gate Transistor
Authors: Cong Thinh Dang , Hoang Trang
Published: January 2024

Floating-gate transistor lies at the heart of many aspects of semiconductor applications such as neural networks, analog mixed-signal, neuromorphic computing, and especially in nonvolatile memories. The purpose of this paper was to design a high-performance nanocrystal floating-gate transistor in terms of a large memory window, low power, and extraordinary erasing speeds. Besides, the transistor achieves a thin thickness of the tunnel gate oxide layer. In order to obtain the high-performance design, this work proposed a set of structure parameters for the device such as the tunnel oxide layer thickness, Interpoly Dielectric (IPD), dot dimension, and dot spacing. Besides, this work was successful in the virtual fabrication process and methodology to fabricate and characterize the 65 nm nanocrystal floating-gate transistor. Regarding the results, while the fabrication process solves the limitation of the tunnel oxide layer thickness with the small value of 6 nm, the performance of the transistor has been significantly improved, such as 2.8 V of the memory window with the supply voltage of ±6 V at the control gate. In addition, the operation speeds are compatible, especially the rapid erasing speeds of 2.03 μs, 28.6 ns, and 1.6 ns when the low control gate voltages are ±9 V, ±12 V, and ±15 V, respectively.
Genistein Ameliorated Vascular Endothelial Growth Factor-A (VEGF-A) and Estrogen Receptor-Alpha (ER-α) in Endometriosis Mice Model, In Vivo and In Silico
Authors: Sutrisno Sutrisno , Maharani Maharani
Published: January 2024

Endometriosis (EM) is a gynecological disorder that causes morbidity in women and is characterized by endometrial tissue in the uterus cavity. This study investigated the mechanism of genistein in the VEGF-A and ER-α expression through in vivo and in silico approaches. An in vivo study was conducted by thirty-six mice that were divided into six groups including control, EM, and EM treatment with genistein with the doses of 1.3, 1.95, 2.6, and 3.25 mg/day for 14 days. Peritoneal tissues with lesions were collected and analyzed by immunohistochemistry to measure the VEGF-A and ER-α expression. The data were analyzed using a statistical approach using one-way ANOVA followed by Tukey HSD test with a significant value p<0.05. In silico study was conducted for investigating the inhibition mechanism of genistein in VEGF-A and ER-α protein. Genistein significantly reduced the VEGF-A and ER-α expression with the optimum dose of 3.25 mg/day. Molecular docking showed that genistein inhibited VEGF-A in several active site residues of VEGF-A, also blocked the ER-α protein in estradiol binding sites. This study concluded that genistein prevented endometriosis by performing the antiangiogenic activity and showed a similar function to estradiol.
Fractional‐Order Model for Evolution of Bovine Tuberculosis with Vaccination and Contaminated Environment
Authors: Diallo Boubacar , Okelo Jeconia Abonyo , Osman Shaibu , Karanja Simon , Aguegboh Nnaemeka Stanley
Published: January 2024

Bovine tuberculosis (bTB) is a zoonotic disease that is commonly transmitted via inhaling aerosols, drinking unpasteurized milk, and eating raw meat. We use a fractional‐order model with the Caputo sense to examine the evolution of bovine tuberculosis transmission in human and animal populations, including a vaccine compartment for humans. We derived and obtained the threshold quantity R0 to ascertain the illness state. We established conditions guaranteeing the asymptotic stability of the equilibria (locally and globally). Sensitivity analysis was conducted to identify the factors that govern the dynamics of tuberculosis. The study demonstrates that the rate of human‐to‐animal transmission of tuberculosis and environmental pollution and the rate of bTB transmission between animals all affect tuberculosis transmission. However, as vaccination rates increase and fewer individuals consume contaminated environment products (such as meat, milk, and other dairy products), the disease becomes less common in humans. To manage bovine TB, it is advised that information programmes be implemented, the environment be monitored, infected persons be treated, contaminated animals be vaccinated, and contaminated animals be quarantined. The usefulness of the discovered theoretical results is demonstrated through numerical experiments.
Supplementary Table 3 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy
Authors: De Schepper Maxim , Nguyen Ha-Linh , Richard François , Rosias Louise , Lerebours Florence , Vion Roman , Clatot Florian , Berghian Anca , Maetens Marion , Leduc Sophia , Isnaldi Edoardo , Molinelli Chiara , Lambertini Matteo , Grillo Federica , Zoppoli Gabriele , Dirix Luc , Punie Kevin , Wildiers Hans , Smeets Ann , Nevelsteen Ines , Neven Patrick , Vincent-Salomon Anne , Larsimont Denis , Duhem Caroline , Viens Patrice , Bertucci François , Biganzoli Elia , Vermeulen Peter , Floris Giuseppe , Desmedt Christine
Published: January 2024

Supplementary Table 3 shows pCR rates and sTIL according to histology.
Supplementary Table 1 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy
Authors: De Schepper Maxim , Nguyen Ha-Linh , Richard François , Rosias Louise , Lerebours Florence , Vion Roman , Clatot Florian , Berghian Anca , Maetens Marion , Leduc Sophia , Isnaldi Edoardo , Molinelli Chiara , Lambertini Matteo , Grillo Federica , Zoppoli Gabriele , Dirix Luc , Punie Kevin , Wildiers Hans , Smeets Ann , Nevelsteen Ines , Neven Patrick , Vincent-Salomon Anne , Larsimont Denis , Duhem Caroline , Viens Patrice , Bertucci François , Biganzoli Elia , Vermeulen Peter , Floris Giuseppe , Desmedt Christine
Published: January 2024

Supplementary Table 1 shows clinicopathological characteristics of the entire cohort and the sub-cohort with central pathology performed.
FIGURE 5 from Treatment Response, Tumor Infiltrating Lymphocytes and Clinical Outcomes in Inflammatory Breast Cancer–Treated with Neoadjuvant Systemic Therapy
Authors: De Schepper Maxim , Nguyen Ha-Linh , Richard François , Rosias Louise , Lerebours Florence , Vion Roman , Clatot Florian , Berghian Anca , Maetens Marion , Leduc Sophia , Isnaldi Edoardo , Molinelli Chiara , Lambertini Matteo , Grillo Federica , Zoppoli Gabriele , Dirix Luc , Punie Kevin , Wildiers Hans , Smeets Ann , Nevelsteen Ines , Neven Patrick , Vincent-Salomon Anne , Larsimont Denis , Duhem Caroline , Viens Patrice , Bertucci François , Biganzoli Elia , Vermeulen Peter , Floris Giuseppe , Desmedt Christine
Published: January 2024

Association of pCR with OS. A, Kaplan–Meier curves of OS according to pCR. B, Forest plots showing the association of pCR and standard clinicopathologic and treatment variables with OS quantified by Cox regression.
Patient Experience and Preferences for the Assessment of Olfaction: The Patient International Clinical Assessment of Smell Survey
Authors: Whitcroft Katherine L. , Kelly Christine , Andrews Peter
Published: January 2024

Introduction: Olfactory dysfunction (OD) is common and carries significant personal and societal burden of disease. Accurate assessment of olfaction is required for good clinical care and affords patients insight into their condition. However, the accuracy of assessment varies with technique used, and there is presently little standardisation of clinical practice. We therefore aimed to determine experience of and preferences for olfactory assessment in healthcare-seeking adults. Methods: An anonymous patient co-produced survey was developed in collaboration with a UK-based OD charity. Distribution was via their social media patient forum. “Healthcare seeking” adults (i.e., who had undergone olfactory assessment by a healthcare professional [any care level/speciality] or may do so in the future) were included. Results: 576 people (88.5% female, mean 46 years) responded. Hyposmia, parosmia, and retronasal OD were most frequently reported. 55.2% had been assessed by a healthcare professional – GP most commonly, followed by ENT. Importantly, only 15.6% and 16.9% of respondents had undergone systematic assessment with smell tests or symptom questionnaires, respectively. Most respondents had not undergone imaging. Mean satisfaction was higher in those seen by ENT. Interestingly, respondents prioritise orthonasal odour identification over other forms of smell test. Unfortunately, many felt that healthcare professionals (across specialities) were dismissive towards OD and lacked appropriate knowledge of both its pathophysiology and effects. We propose simple steps that can be taken to improve olfactory assessment, including education and establishment of robust referral networks. Conclusion: We hope these results and supporting practical recommendations will inform future service planning, funding allocation and research, as well as better aligning patient and clinician priorities.
New Asian Andrena species, with notes on the subgenus Cnemidandrena (Hymenoptera: Andrenidae)
Authors: WOOD T.J.
Published: January 2024

Asia is the world’s largest continent and comprises most of the Holarctic biogeographic region. The genus Andrena is principally distributed through the Holarctic, but it remains understudied in Asia. The subgenus Cnemidandrena Hedicke, 1933 is distributed across Asia with some species reaching south to the Tibetan Plateau. However, some southern members display an unusual morphology, including A. (Cnemidandrena) kishidai chagyabensis Wu, 1982 (newly recorded for Bhutan, India, and Nepal) and A. (Cnemidandrena) granulitergorum Tadauchi & Xu, 2002 (newly recorded for Nepal). The male of A. granulitergorum is described for the first time, A. (Cnemidandrena) rufina Morawitz, 1876 is reported from Kyrgyzstan, Afghanistan, and Kashmir for the first time, and possible senior synonyms for Asian A. (Cnemidandrena) are suggested. To contribute to an improved understanding of localised Asian Andrena diversity, the following new species are described: A. (Cnemidandrena) textrix sp. nov. from China, A. (incertae sedis) liebigi sp. nov. and A. (Troandrena) monfaredi sp. nov. from Iran, and A. (incertae sedis) quercorum sp. nov. from Turkey. These results further confirm that additional taxonomic work is needed to harmonise Andrena species concepts across the different biogeographic regions of Asia.
The taxonomic identity of Trigona lacteipennis Friese, 1900 and description of a new bee species of the Trigona cilipes (Fabricius, 1804) group (Hymenoptera: Apidae: Meliponini)
Authors: OLIVEIRA FAVÍZIA FREITAS DE , ENGEL MICHAEL S. , RASMUSSEN CLAUS , RIBEIRO CRISTIANO FEITOSA , URBAN DANÚNCIA
Published: January 2024

A critical study of type material for Trigona lacteipennis Friese, 1900 and allied species is presented along with a discussion of literature data. This work reveals that T. lacteipennis is a junior subjective synonym of Melipona paupera Provancher, 1889 (new synonymy), a species currently classified placed in the genus Frieseomelitta. Similarly, T. lehmanni Friese, 1901 and T. parastigma Cockerell, 1918 are also junior subjective synonyms of Melipona paupera (new synonymies). Morphological characters, photographic illustrations of type specimens, and data on distribution are provided for Frieseomelitta paupera. Also, we describe a new species of Trigona cilipes species group, Trigona (Aphaneuropsis) silveirai sp. nov., which is very similar to the former and had been misidentified with it.
Trends in Legal Firearm Transactions: A Possible Protective Role of Gun Law Strength
Authors: Paladugu Anushka , Shipley Jonathan , Grigorian Areg , Qazi Alliya , Kong Allen , Kuza Catherine , Donnelly Megan , Nahmias Jeffry
Published: January 2024

Introduction

The United States (US) holds the highest personal firearm ownership among industrialized nations, with implications for firearm-related deaths tied to increased per capita gun ownership and varying gun laws. This study examines the influence of gun law strength on legal firearm transactions, positing a correlation between stronger laws and reduced transactions. The analysis, focused on the stress-laden COVID-19 pandemic, evaluates handgun, long gun, and multiple gun transactions in 2020 and 2021 compared to 2018-2019.

Methods

The Giffords Gun Law scorecard categorized states into the top 25 “strong” and bottom 25 “weak” gun law groups. Multivariate linear regressions assessed the association between strong gun law states and monthly National Instant Criminal Background Check System (NICS) data from 2018 to 2021. The study queried NICS for handgun, long gun, and multiple gun transactions, comparing median monthly transactions in 2018 and 2019 to 2020 and 2018-2020 to 2021.

Results

When evaluating gun law strength through multivariate linear regression models, stronger gun law states had fewer monthly NICS transactions for handguns, long guns, and multiple guns in 2020 and 2021 versus all comparison years (all P < .05). However, from 2018-2019 to 2020 and 2018-2020 to 2021, median monthly NICS transactions per 100,000 people for all gun types increased (all P < .05).

Conclusion

Stricter gun laws correlated with decreased firearm transactions in stronger law states, yet handgun, long gun, and multiple gun transactions increased during the pandemic years of 2020 and 2021. Therefore, strengthening firearm legislation may be protective against the proliferation of firearms, which warrants further research.
Reinterpreting human rights in the climate crisis: Moving beyond economic growth and (un)sustainable development to a future with degrowth
Authors: Bueno de Mesquita Judith
Published: January 2024

The UN General Assembly has recently recognised that unsustainable development and climate change ‘constitute some of the most pressing and serious threats to the ability of present and future generations to effectively enjoy all human rights’. International human rights law is evolving to obligate States to tackle climate change, including through mitigation measures. At the same time, economic growth and sustainable development are often upheld to underpin the realisation of human rights. However, economic growth is a significant contributor to climate change, which, in turn, harms human rights. This article argues that these contradictions require a recalibrated interpretation of economic growth under international human rights law, in particular in terms of; (i) the nature of the relationship between human rights and sustained economic growth in Global North States, which disproportionately contribute to climate change, and consequentially (ii) the degree of alignment of the 2030 Agenda on Sustainable Development with international human rights law. Different visions are abounding for ecologically sustainable social and economic life. This includes proposals for degrowth which centre on a planned reduction in consumption and use of resources, especially in the Global North. This article uses degrowth as a case study to argue that such proposals provide crucial insights to support the interpretation of, and pathways for, the realisation of human rights within planetary boundaries, and to shape a rights-based, and sustainable post-2030 development landscape.
A comparison of model-free phase I dose escalation designs for dual-agent combination therapies
Authors: Barnett Helen , George Matthew , Skanji Donia , Saint-Hilary Gaelle , Jaki Thomas , Mozgunov Pavel
Published: January 2024

It is increasingly common for therapies in oncology to be given in combination. In some cases, patients can benefit from the interaction between two drugs, although often at the risk of higher toxicity. A large number of designs to conduct phase I trials in this setting are available, where the objective is to select the maximum tolerated dose combination. Recently, a number of model-free (also called model-assisted) designs have provoked interest, providing several practical advantages over the more conventional approaches of rule-based or model-based designs. In this paper, we demonstrate a novel calibration procedure for model-free designs to determine their most desirable parameters. Under the calibration procedure, we compare the behaviour of model-free designs to model-based designs in a comprehensive simulation study, covering a number of clinically plausible scenarios. It is found that model-free designs are competitive with the model-based designs in terms of the proportion of correct selections of the maximum tolerated dose combination. However, there are a number of scenarios in which model-free designs offer a safer alternative. This is also illustrated in the application of the designs to a case study using data from a phase I oncology trial.
The Future of Work: Understanding the Effectiveness of Collaboration Between Human and Digital Employees in Service
Authors: Le Khanh B. Q. , Sajtos Laszlo , Kunz Werner H. , Fernandez Karen V.
Published: January 2024

The use of digital employees (DEs)—chatbots powered by artificial intelligence (AI)—is becoming increasingly common in the service industry. However, it is unclear whether collaborations between the human employee (HE) and DE can influence customer outcomes, and what the mechanisms behind such outcomes are. This research proposes and tests a theoretical model that explains how the communication of HE-DE collaboration in the form of interdependent behavioral cues can influence customer evaluations of the service they received from such a team. Five experimental studies involving a total of 1403 participants demonstrate that making HE-DE collaboration visible to customers during the service encounter can reinforce their perception of HE-DE team cohesiveness and service process fluency, driving satisfaction. The communication of coordination and team goal cues are two strong stimulants that strengthen such impressions. Further, this research also reveals that the HE-DE collaboration (vs. augmentation or substitution) appeals to customers thanks to their perception of a transparent process, which is induced through collaborative cues. This research provides theoretical implications for a transparent collaborative process between HE and DE and practical advice for firms seeking to integrate DE into their organizations’ workflows.
Evaluation of paediatric palliative care ambulance plans: A retrospective study
Authors: Wan Julianna , Vaughan Angela , Shepherd Elizabeth , Coombs Sandra , Trethewie Susan , Jaaniste Tiina
Published: January 2024

Paediatric Palliative Care Ambulance Plans (‘Plans’) are used by New South Wales Ambulance (Australia) to support the care needs of children with life-limiting conditions. We aimed to describe the population of children with Plans and provide details regarding Plan completion, paramedic responses during ambulance callouts, and correspondence between Plan recommendations and paramedic responses. Plans lodged in January 2017–December 2019 were retrospectively coded for demographic information, completeness and care preferences. Associated paramedic callout notes (January 2018–December 2019) were coded for paramedic responses. Of 141 Plans retrieved, 38 (41.3% of those providing suggested medications) suggested medication use outside general paramedic scope of practice. Of 199 associated ambulance callouts, reasons for callout included symptom management, planned transfer, death notification and end-of-life care. Over two-thirds of callouts ( n = 135, 67.8%) occurred after-hours. Most paramedic callouts ( n = 124, 62.3%), excluding planned transfers, resulted in children being transported. Paramedic interventions corresponded with interventions suggested in Plans. However, only 24 (25.3%) of paramedic callout notes documented Plans being sighted. This study provided detailed information about children with palliative care needs for whom Plans were being used, the nature of these Plans and associated paramedic callouts. However, it is not known how paramedics were influenced by Plans.
An asymmetric model two-dimensional oscillator
Authors: Rath B , Erturk VS , Asad Jihad , Mallick P , Jarrar Rabab
Published: January 2024

We present a novel 2D oscillator with an asymmetric design and investigate its stable vibration utilizing the Ms-DTM method. Initially, we obtain the equations of motion for the proposed system. Subsequently, by employing Taylor expansion of [Formula: see text] and [Formula: see text], the derived nonlinear equations are transformed into linear ones, which we solve analytically using the eigenvalues-eigenfunctions technique. Additionally, we solve the obtained nonlinear system using the Ms-DTM method. Lastly, we examine the stability of the nonlinear system by visualizing the closed nature of the phase portrait.
Physical Activity Policy, Systems, and Environment Change Through Extension SNAP-Ed: A Multistate Perspective
Authors: Stroope Jessica , Umstattd Meyer M. Renée , Gabbert Kerry , John Deborah H. , Kellstedt Debra , Orzech Kathryn M. , Wende Marilyn E.
Published: January 2024

The Supplemental Nutrition Assistance Program-Education (SNAP-Ed) provides nutrition education and support for healthy living in SNAP-qualifying communities. SNAP-Ed supports policy, systems, and environmental (PSE) efforts to make the healthy choice an easier choice. SNAP-Ed implementers have widely adopted healthy eating PSE supports. However, physical activity (PA) PSE strategies are less common, with limited awareness between states of how other SNAP-Ed implementers approach PA-focused PSE work. Physical Activity Policy, Research, and Evaluation Network (PAPREN) Rural Active Living Workgroup project members sought to explore how Extension-based SNAP-Ed implements PA-focused PSE approaches. A sample of Extension-based SNAP-Ed program ( n = 8) leaders were purposefully recruited from eligible universities in six of the seven SNAP-Ed regions. An interview guide to systematically collect information about current Extension SNAP-Ed implementation focused on PA PSE strategies was developed iteratively by the PAPREN Rural Active Living Workgroup Extension PA PSE project team. PA PSE Extension SNAP-Ed implementation efforts occurred at the state, county, and community levels and/or within local organizations. PA PSEs included school PA policy change, shared-use agreements, active transportation promotion, park development, walking challenges, and PA-promoting signage. All interviews highlighted the importance of partnerships at local, county, and state levels for PSE efforts. Extension-based SNAP-Ed shows potential to bring community partners together to plan and implement PA-focused PSE approaches. With a focus on SNAP-eligible people and substantial geographic reach, Extension SNAP-Ed is uniquely situated as a public health partner to broadly implement PA PSE changes.
When a Negative Experience Sticks With You: Does the Revised Outcome Debriefing Counteract the Consequences of Experimental Ostracism in Psychological Research?
Authors: Miketta Stefanie , Friese Malte
Published: January 2024

For research purposes, it is generally accepted that experimental ostracism manipulations can lead to a reduction of participants’ well-being. To eventually restore participants’ well-being, researchers rely on post-experimental debriefings that discredit prior deception. However, evidence suggests that discredited beliefs can persevere. The present research investigates whether a potent debriefing procedure restores participants’ well-being after an experimentally induced ostracism experience. In two studies, participants were either excluded or included in a Cyberball game, indicated their well-being, and were debriefed. In two additional conditions, participants were debriefed before indicating their well-being. Ostracism compared to inclusion led to decreased positive and increased negative mood. The debriefing did not counteract this effect (Studies 1 & 2). Unwanted aftereffects of the manipulation persevered for more than one day after the experimental session (Study 2). These findings question the effectiveness of debriefings and raise issues about research ethics.
Adaptation for sustainability in an implementation trial of team-based collaborative care
Authors: Miller Christopher J. , Sullivan Jennifer L. , Connolly Samantha L. , Richardson Eric J. , Stolzmann Kelly L. , Brown Madisen , Bailey Hannah M. , Weaver Kendra , Sippel Lauren , Kim Bo
Published: January 2024

Background

Sustaining healthcare interventions once they have been implemented is a pivotal public health endeavor. Achieving sustainability requires context-sensitive adaptations to evidence-based practices (EBPs) or the implementation strategies used to ensure their adoption. For replicability of adaptations beyond the specific setting in question, the underlying logic needs to be clearly described, and adaptations themselves need to be plainly documented. The goal of this project was to describe the process by which implementation facilitation was adapted to improve the uptake of clinical care practices that are consistent with the collaborative chronic care model (CCM).

Method

Quantitative and qualitative data from a prior implementation trial found that CCM-consistent care practices were not fully sustained within outpatient general mental health teams that had received 1 year of implementation facilitation to support uptake. We undertook a multistep consensus process to identify adaptations to implementation facilitation based on these results, with the goal of enhancing the sustainability of CCM-based care in a subsequent trial. The logic for these adaptations, and the resulting adaptations themselves, were documented using two adaptation-oriented implementation frameworks (the iterative decision-making for evaluation of adaptations [IDEA] and the framework for reporting adaptations and modifications to evidence-based implementation strategies [FRAME-IS], respectively).

Results

Three adaptations emerged from this process and were documented using the FRAME-IS: (a) increasing the scope of implementation facilitation within the medical center, (b) having the internal facilitator take a greater role in the implementation process, and (c) shortening the implementation timeframe from 12 to 8 months, while increasing the intensity of facilitation support during that time.

Conclusions

EBP sustainability may require careful adaptation of EBPs or the implementation strategies used to get them into routine practice. Recently developed frameworks such as the IDEA and FRAME-IS may be used to guide decision-making and document resulting adaptations themselves. An ongoing funded study is investigating the utility of the resulting adaptations for improving healthcare.
Relationship between systemic immune inflammation index and development of complete atrioventricular block in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
Authors: Esin Fatma , Esen Saban , Aktürk Semih , Pekersen Ömer , Kiris Tuncay , Karaca Mustafa
Published: January 2024

Background

The systemic immune-inflammation index (SII), based on white blood cell, neutrophil, and platelet counts, is a proposed marker of systemic inflammation and immune activation. This study aimed to explore the relationship between SII and complete atrioventricular block (CAVB) development in STEMI patients undergoing primary PCI.

Methods

We retrospectively analyzed data from 883 patients who underwent primary PCI for STEMI between January 2009 and December 2017. Patients were categorized into two groups based on CAVB development. SII levels were calculated from blood samples taken on admission.

Results

Of the included patients, 48 (5.03%) developed CAVB. SII was higher in patients with CAVB compared to those without CAVB (1370 [1050–1779]x109/L vs. 771 [427–1462] x109/L, p < 0.001). Multivariate analysis showed a significant positive correlation between SII and the risk of CAVB development (OR:1.0003, 95%CI:1.0001–1.0005, P = 0.044). The cut-off value for the SII in the estimation of CAVB was 1117.7 × 109/L (area under the ROC curve [AUC]: 0.714, 95% CI = 0.657–0.770 with a sensitivity of 70.8% and specificity of 65.6%, p < 0.001).

Conclusion

This study showed a significant link between high SII levels and CAVB development in STEMI patients undergoing PCI. Our findings suggest that SII may be a valuable, routinely available, and inexpensive marker for identifying patients at increased risk of CAVB.
Attitudes and barriers to breastfeeding among women at high-risk for not breastfeeding: a prospective observational study
Authors: Cole Jessica , Bhatt Ateshi , Chapple Andrew G. , Buzhardt Sarah , Sutton Elizabeth F.
Published: January 2024

Background

Rates of breastfeeding are lower among minority and underserved populations in the United States. Our study objective was to assess pregnant persons attitudes and barriers to breastfeeding among a cohort at high risk for not breastfeeding.

Methods

We disseminated the Iowa Infant Feeding Attitude Scale (IIFAS) to 100 pregnant persons at least 18 years of age attending a prenatal visit in a low-resource, academic practice in south-central Louisiana (Woman’s Hospital). The IIFAS, as well as questions collecting information on breastfeeding experience and sociodemographic characteristics, were administered via interview. Medical records were reviewed to investigate associations between attitudes about breastfeeding in pregnancy and patient’s feeding choices during the delivery hospital stay. Fisher exact tests and Wilcoxon rank-sum tests were used to assess associations between categorical and continuous variables respectively.

Results

Of the 98 participants who completed the study, 8% were Hispanic, 63% were Black, 95% were Medicaid eligible, and 50% were unemployed. 59% (n = 58) went on to breastfeed/combination breast-formula feed (called “Any-Breastfeeding Group”) during the delivery stay. Total IIFAS score during pregnancy was significantly higher among those who went on to breastfeed during delivery hospital stay (Any-Breastfeeding Group vs. Formula-Feeding-Only Group: 58.9 ± 5.5 vs. 53.7 ± 6.2 respectively, p < 0.001). In the group that went on to only formula feed (Formula-Feeding-Only Group), only 4% agreed breastfeeding was more convenient when surveyed during pregnancy, compared to 45% of the Any-Breastfeeding Group. 60% of Formula-Feeding-Only Group agreed formula is as healthy as breast milk.

Conclusion

The three major themes that coincided with favorability toward breastfeeding in the study, and can be addressed during prenatal counseling, are: mother-infant bonding, convenience, and health benefits. By identifying attitudes and barriers to breastfeeding for patients during pregnancy who went on to not breastfeed, directed educational opportunities can be developed to address these specific attitudes to ultimately increase breastfeeding initiation and continuation.
Systemic inflammation, enteropathogenic E. Coli, and micronutrient insufficiencies in the first trimester as possible predictors of preterm birth in rural Bangladesh: a prospective study
Authors: Gerety Meghan K. , Kim Debora K. , Carpenter Rebecca M. , Ma Jennie Z. , Chisholm Christian , Taniuchi Mami , Islam Md Ohedul , Pholwat Suporn , Platts-Mills James A. , Siraj Md Shahjahan , Billah Sk Masum , Haque Rashidul , Petri William A.
Published: January 2024

Background

An incomplete understanding of preterm birth is especially concerning for low-middle income countries, where preterm birth has poorer prognoses. While systemic proinflammatory processes are a reportedly normal component of gestation, excessive inflammation has been demonstrated as a risk factor for preterm birth. There is minimal research on the impact of excessive maternal inflammation in the first trimester on the risk of preterm birth in low-middle income countries specifically.

Methods

Pregnant women were enrolled at the rural Bangladesh site of the National Institute of Child Health Global Network Maternal Newborn Health Registry. Serum samples were collected to measure concentrations of the inflammatory markers C-reactive protein (CRP) and Alpha-1-acid glycoprotein (AGP), and stool samples were collected and analyzed for enteropathogens. We examined associations of maternal markers in the first-trimester with preterm birth using logistic regression models. CRP and AGP were primarily modeled with a composite inflammation predictor.

Results

Out of 376 singleton births analyzed, 12.5% were preterm. First trimester inflammation was observed in 58.8% of all births, and was significantly associated with increased odds of preterm birth (adjusted odds ratio [aOR] = 2.23; 95% confidence interval [CI]: 1.03, 5.16), independent of anemia. Maternal vitamin B12 insufficiency (aOR = 3.33; 95% CI: 1.29, 8.21) and maternal anemia (aOR = 2.56; 95% CI: 1.26, 5.17) were also associated with higher odds of preterm birth. Atypical enteropathogenicE. colidetection showed a significant association with elevated AGP levels and was significantly associated with preterm birth (odds ratio [OR] = 2.36; 95% CI: 1.21, 4.57), but not associated with CRP.

Conclusions

Inflammation, anemia, and vitamin B12 insufficiency in the first trimester were significantly associated with preterm birth in our cohort from rural Bangladesh. Inflammation and anemia were independent predictors of premature birth in this low-middle income setting where inflammation during gestation was widespread. Further research is needed to identify if infections such as enteropathogenicE. coliare a cause of inflammation in the first trimester, and if intervention for infection would decrease preterm birth.
Protocol for the development of a Core Outcome Set (COS) for Adolescents and Young Adults (AYAs) with cancer
Authors: Husson Olga , Janssen Silvie H. M. , Reeve Bryce B. , Sodergren Samantha C. , Cheung Christabel K. , McCabe Martin G. , Salsman John M. , van der Graaf Winette T. A. , Darlington Anne-Sophie
Published: January 2024

Background

Adolescents and young adults (AYAs) with cancer, defined as individuals aged 15–39 years at initial cancer diagnosis, form a unique population; they face age-specific issues as they transition to adulthood. This paper presents the protocol for the development of a core outcome set (COS) for AYAs with cancer.

Methods

The methodological standards from the Core Outcome Measures in Effectiveness Trials (COMET) and the International Consortium for Health Outcomes Measurement (ICHOM) for COS development will guide the development of the COS for AYAs with cancer. The project will consist of the following phases: (1) define the scope of the COS; (2) establish the need for a COS in this field (3) assemble an international, multi-stakeholder working group; (4) develop a detailed protocol; (5) determine “what to measure” (i.e., outcomes); (6) determine “how to measure” (i.e., measures); and (7) determine “case-mix” variables.

Conclusions

The development of a COS for AYAs with cancer will facilitate the implementation of efficient and relevant standards for data collection, both for clinical trials and in routine healthcare, thereby increasing the usefulness of these data to improve the value of the care given to these underserved young cancer patients.
A novel computer-assisted tool for 3D imaging of programmed death-ligand 1 expression in immunofluorescence-stained and optically cleared breast cancer specimens
Authors: Lee Yi-Hsuan , Huang Chung-Yen , Hsieh Yu-Han , Yang Chia-Hung , Hung Yu-Ling , Chen Yung-An , Lin Yu-Chieh , Lin Ching-Hung , Lee Jih-Hsiang , Wang Ming-Yang , Kuo Wen-Hung , Lin Yen-Yin , Lu Yen-Shen
Published: January 2024

Background

Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) are the two most common immune checkpoints targeted in triple-negative breast cancer (BC). Refining patient selection for immunotherapy is non-trivial and finding an appropriate digital pathology framework for spatial analysis of theranostic biomarkers for PD-1/PD-L1 inhibitors remains an unmet clinical need.

Methods

We describe a novel computer-assisted tool for three-dimensional (3D) imaging of PD-L1 expression in immunofluorescence-stained and optically cleared BC specimens (n = 20). The proposed 3D framework appeared to be feasible and showed a high overall agreement with traditional, clinical-grade two-dimensional (2D) staining techniques. Additionally, the results obtained for automated immune cell detection and analysis of PD-L1 expression were satisfactory.

Results

The spatial distribution of PD-L1 expression was heterogeneous across various BC tissue layers in the 3D space. Notably, there were six cases (30%) wherein PD-L1 expression levels along different layers crossed the 1% threshold for admitting patients to PD-1/PD-L1 inhibitors. The average PD-L1 expression in 3D space was different from that of traditional immunohistochemistry (IHC) in eight cases (40%). Pending further standardization and optimization, we expect that our technology will become a valuable addition for assessing PD-L1 expression in patients with BC.

Conclusion

Via a single round of immunofluorescence imaging, our approach may provide a considerable improvement in patient stratification for cancer immunotherapy as compared with standard techniques.