bluuebunny/crossref_metadata_2025 huggingface dataset:
Kepailitan Terhadap Ahli Waris Penanggung yang Perjanjian Penanggungannya Tanpa Persetujuan Istri Penanggung
Authors: Sangkai Tia De
Published: December 2022

AbstractIt is often found that one of the parties, the husband or wife acts on common property without agreement from the marriage partner, which can lead to cases. The real case taken by the author arising from this action is that the heir before death has become a guarantor but in making a guarantee agreement (borgtocht) with the insured there is no agreement by the wife of the guarantor. In this case the creditor can sue for bankruptcy if the creditor can prove that the guarantor has two or more creditors and has not paid off at least one debt that has due and is collectible, which is a requirement that is expressly stated in Article 2 paragraph (1) of Law Number 37 year 2004 concerning Bankruptcy and Suspension of Liability Debt Payment. Then the heir can be filed for bankruptcy to replace the position of the guarantor. Keywords: Common Property; the Heirs; Guarantee Agreement; Bankruptcy.
AbstrakSeringkali ditemukan terdapat salah satu pihak yaitu suami atau istri yang bertindak mengenai harta bersama tanpa persetujuan pasangan kawinnya, yang mana hal tersebut dapat menimbulkan kasus. Kasus nyata yang ditarik oleh penulis yang timbul dari adanya tindakan tersebut yaitu pewaris sebelum meninggal telah menjadi penanggung namun dalam pembuatan perjanjian penanggungan (borgtocht) dengan tertanggung perjanjian tersebut tidak ada persetujuan oleh istri penanggung. Dalam hal ini kreditor mengajukan permohonan pailit apabila kreditor dapat membuktikan bahwa penanggung tersebut memiliki dua atau lebih kreditor dan tidak membayar lunas sedikitnya satu utang yang telah jatuh waktu dan dapat ditagih, yang mana hal tersebut merupakan syarat yang secara tegas dicantumkan dalam pasal 2 ayat (1) Undang-Undang Nomor 37 Tahun 2004 tentang Kepailitan dan Penundaan Kewajiban Pembayaran Utang. Maka ahli waris dapat dimohonkan pailit yang menggantikan posisi penanggung. Kata Kunci: Harta Bersama; Perjanjian Penanggungan; Ahli Waris; Kepailitan.
Sistem Pembuktian Gugatan Lain-Lain dalam Kepailitan
Authors: Patricia Yoshe Agatha
Published: December 2022

AbstractBankruptcy is a general confiscation of all debtor's assets to pay debtors' debts to all their creditors collectively. To file for bankruptcy, two requirements need to be met, namely the debtor has two or more creditors and debts that have matured and can be collected (Article 2 Paragraph (1) of the UUK and PKPU, if these two requirements have been fulfilled, the Commercial Court must grant the petition for bankruptcy based on Article 8 Paragraph (4) UUK and PKPU Consequences of general confiscation of the assets of a bankrupt debtor can cause new problems or disputes to the Commercial Court, but based on the explanation following the authority of Article 8 Paragraph (4) UUK and PKPU. So, in this case there is uncertainty about the procedure for examining other lawsuits based on the explanation of Article 3 Paragraph (1) of the UUK and PKPU against the bankruptcy authority as regulated in Article 8 Paragraph (4) UUK and PKPU. Keywords: Bankruptcy; Micellaneous Lawsuits; Debtors; Creditors; Commercial Courts.
AbstrakKepailitan merupakan sita umum terhadap seluruh harta debitor untuk membayar utang-utang debitor kepada seluruh kreditor-nya secara kolektif. Untuk mengajukan permohonan pailit perlu dipenuhinya dua persyaratan yaitu debitor memiliki dua kreditor atau lebih dan utang yang telah jatuh tempo dan dapat ditagih (Pasal 2 Ayat (1) UUK dan PKPU, apabila telah terpenuhinya dua persyaratan tersebut maka Pengadilan Niaga harus mengabulkan permohonan pailit berdasarkan Pasal 8 Ayat (4) UUK dan PKPU. Konsekuensi dari sita umum terhadap harta debitor pailit, dapat menimbulkan permasalahan atau sengketa baru, berdasarkan Pasal 3 Ayat (1) UUK dan PKPU, permasalahan/sengketa yang timbul akibat kepailitan dapat diajukan sebagai Gugatan Lain-Lain ke Pengadilan Niaga, namun berdasarkan penjelasannya mengikuti kewenangan Pasal 8 Ayat (4) UUK dan PKPU. Sehingga dalam hal ini terdapatnya ketidakpastian tata cara pemeriksaan perkara Gugatan Lain-Lain berdasarkan penjelasan Pasal 3 Ayat (1) UUK dan PKPU terhadap kewenangan kepailitan sebagaimana diatur dalam Pasal 8 Ayat (4) UUK dan PKPU. Kata Kunci: Kepailitan; Gugatan Lain-Lain; Debitor; Kreditor; Pengadilan Niaga.
Combination of 5% Dextrose Ringer’s solution and egg yolk extender maintained the motility and viability of kampung rooster spermatozoa in chilled temperature
Authors: Ahmad Hanif Azzam  , Dadik Rahardjo  , Tatik Hernawati  , Sri Pantja Madyawati  , Budi Utomo
Published: December 2022

This study aims to determine the motility and viability of kampung rooster (Gallus domesticus) spermatozoa in 5% Dextrose Ringer’s solution as an extender with or without the addition of various egg yolk concentrations at 5ºC during storage. Semen was collected by massage in the morning. In this study, four types of extenders were used, i.e., 5% Dextrose Ringer’s extender without egg yolk, 5% Dextrose Ringer’s extender with 5, 7.5, and 10% egg yolk for T0, T1, T2, and T3, respectively. Then, 1000 IU Penicillin and 1 mg Streptomycin were added per mL extender. Fresh semen from each rooster was evenly divided into four volumes to be diluted 11 times in each group extender. Extended semen from all groups was stored at 5°C. Data were analyzed using ANOVA and Duncan's new multiple range test. The result showed a significant difference (p <0.05) between each treatment group for spermatozoa motility and viability. In conclusion, this study revealed that the addition of various concentrations of egg yolk into 5% Dextrose Ringer’s solution as an extender maintained the motility and viability of kampung rooster spermatozoa.
Determination of sexual maturity of Indonesian box turtle (Cuora amboinensis couro) based on straight carapace length
Authors: Daniel Leonardo  , Pudji Srianto  , Iwan Sahrial Hamid  , Boedi Setiawan  , Djoko Legowo  , Hani Plumeriastuti
Published: December 2022

Predicting the turtle's reproductive status and sexual maturity is necessary for ex-situ breeding and conservation program. The histology of the seminiferous tubules of the Indonesian box turtle (Cuora amboinensis couro) at various ages has not been studied much. This study aims to develop equations to predict the sexual maturity of Indonesian box turtles based on straight carapace length (SCL). Six turtles with SCL sizes 10-21 cm were sacrificed and their testes were taken for morphometric measurements and histological preparations for Hematoxylin Eosin staining. Pearson’s correlation of SCL with testicular maturity parameters was analyzed, followed by Anova Regression. The results showed that there were differences in the morphometry and topographic anatomy of the Indonesian box turtle testes between SCL below 15 cm and above 15 cm. Six turtles with SCL size of 10-21 cm were sacrificed and their testes were taken for morphometric measurements and histological preparations for Hematoxylin Eosin staining. Pearson's correlation of SCL with testicular maturity parameters was analyzed, followed by Regression Anova. The results showed that there were differences in the morphometry and topographic anatomy of the Indonesian box turtle testes between SCL below 15 cm and above 15 cm.
Tomato (Lycopersicon esculentum Mill.) juice restored the number of Leydig cells, and the diameter of the seminiferous tubules of mice (Mus musculus) exposed to lead acetate
Authors: Revina Ayu Septiani  , Iwan Sahrial Hamid  , Emy Koestanti Sabdoningrum  , Anwar Ma’ruf  , Eka Pramyrtha Hestianah  , Maslichah Mafruchati
Published: December 2022

Lead is a harmful pollutant from engine exhaust that causes free radicals and has detrimental effects on the testicular tissue. This study aimed to determine the effects of tomato juice on the number of Leydig cells and the diameter of the seminiferous tubules of mice exposed to lead acetate. Twenty-five male mice were divided into five groups. Mice in the control (C-) group were given placebos. Meanwhile, mice in C+, T1, T2, and T3 groups were exposed to lead acetate at a dose of 100 mg/kg BW/day for 14 days and given tomato juice respectively at 0, 0.16, 0.32, and 0.64 mL/day from day 8 to day 35. On day 36, all mice were sacrificed, and the testes were collected for histological preparation. The result showed that lead exposure in the C+ group decreased (p <0.05) in the number of Leydig cells and the diameter of the seminiferous tubules compared to the mice in group C-. Administration of tomato juice in groups T1, T2, and T3 increased (p <0.05) the number of Leydig cells and the diameter of seminiferous tubule compared to the mice in the C+ and C- groups. However, tomato juice administration to the T3 group decreased the number of Leydig cells and the diameter of the seminiferous tubules (p <0.05) compared to the T2 group. In conclusion, an effective dose of 0.32 mL/day of tomato juice restored Leydig cell number and seminiferous tubules diameter in mice exposed to lead acetate.
A new combination of Strobilanthes (Acanthaceae) with two new records from Thailand
Authors:   Department of Biology, Center of Excellence on Biodiversity (BDC) and Applied Taxonomic Research Center (ATRC), Faculty of  Science, Khon Kaen University, Khon Kaen 40002, Thailand, Kladwong Pornchai , Chantaranothai Pranom ,   Department of Biology, Center of Excellence on Biodiversity (BDC) and Applied Taxonomic Research Center (ATRC), Faculty of  Science, Khon Kaen University, Khon Kaen 40002, Thailand,   Honorary Research Associate, Royal Botanic Gardens, Kew, Richmond, Surrey, TW9 3AE, UK
Published: December 2022

Strobilanthes spirei is proposed as a new combination of Clinacanthus spirei. Strobilanthes hypomalla and S. spirei are newly recorded for Thailand. The lectotypification of S. hypomalla is made. A detailed description of morphology and pollen features is provided as well as photographs, distribution map, ecology and taxonomic notes.
Almost C(α)-Manifold on M-Projective Curvature Tensor
Authors: Mert Tuğba , Atçeken Mehmet
Published: December 2022

In this article, the behavior of the C(α)-manifold satisfying the conditions R(X,Y)W∗ = 0,W∗
(X,Y)R = 0,W∗
(X,Y)Z˜ =
0, W∗
(X,Y)S = 0 and W∗
(X,Y)C˜ = 0 on the M−projective curvature tensor is investigated. The C(α)−Manifold is characterized
according to these states of the curvature tensor. Here, W∗
,R,S,Z˜ and C˜ are M−projective, Riemann, Ricci, concircular and quasiconformal curvature tensors
On s-Convex Functions in the Third Sense and New Integral Inequalities
Authors: Kamali Serap , Ünal Baki
Published: December 2022

In this paper, some new integral inequalities are obtained for functions whose n-th derivative is s-convex function in the
third sense with the help of an integral identity.
On the convergence of finite difference scheme for a Schrödinger type equation
Authors: Yildirim Aksoy Nigar
Published: December 2022

In the present paper, an initial boundary value problem for the linear Schrodinger equation including the momentum operator ¨
is introduced. This problem is discretized by the finite difference method and a difference scheme is presented. Moreover, an estimate
for the solution of the proposed scheme is obtained. Finally, with the help of the estimate, it is proved that the proposed scheme is
unconditionally stable and convergent.
Targeting the EGF receptor family in non-small cell lung cancer—increased complexity and future perspectives
Authors: Boch Tobias , Köhler Jens , Janning Melanie , Loges Sonja
Published: December 2022

Lung cancer remains the leading cause of cancer-associated mortality worldwide, but with the emergence of oncogene targeted therapies, treatment options have tremendously improved. Owing to their biological relevance, members of the ERBB receptor family, including the EGF receptor (EGFR), HER2, HER3 and HER4, are among the best studied oncogenic drivers. Activating EGFR mutations are frequently observed in non-small cell lung cancer (NSCLC), and small molecule tyrosine kinase inhibitors (TKIs) are the established first line treatment option for patients whose tumors bear “typical/classical” EGFR mutations (exon 19 deletions, L858R point mutations). Additionally, new TKIs are rapidly evolving with better efficacy to overcome primary and secondary treatment resistance (e.g., that due to T790M or C797S resistance mutations). Some atypical EGFR mutations, such as the most frequent exon 20 insertions, exhibit relative resistance to earlier generation TKIs through steric hindrance. In this subgroup, newer TKIs, such as mobocertinib and the bi-specific antibody amivantamab have recently been approved, whereas less frequent atypical EGFR mutations remain understudied. In contrast to EGFR, HER2 has long remained a challenging target, but better structural understanding has led to the development of newer generations of TKIs. The recent FDA approval of the antibody-drug conjugate trastuzumab-deruxtecan for pretreated patients with HER2 mutant NSCLC has been an important therapeutic breakthrough. HER3 and HER4 also exert oncogenic potential, and targeted treatment approaches are being developed, particularly for HER3. Overall, strategies to inhibit the oncogenic function of ERBB receptors in NSCLC are currently evolving at an unprecedented pace; therefore, this review summarizes current treatment standards and discusses the outlook for future developments.
Fabrication Methods of the Polygonal Masonry of Large Tightly-fitted Stone Blocks with Curved Surface Interfaces in Megalithic Structures of Peru
Authors: Lapshin Rostislav
Published: December 2022

The article suggests methods that allow creating the most complicated type of polygonal masonry found in Peru. This masonry type consists of large stone blocks weighing from several hundred kilograms to several tons fitted close to each other almost without a gap between complicated curved surfaces over a large area. The work provides a description of techniques, which apparently were used by builders who arrived from Europe. The techniques under discussion are based on the use of a reduced clay model, 3D-pantograph, topography translator and replicas. The use of the topography translator, reduced clay model and pantograph provides not only the unique appearance and high quality of masonry of large blocks, but also allows to increase the productivity of the builders significantly. As machines coping-scaling three-dimensional objects are known since the beginning of the 18th century, the stone structures under consideration should be approximately dated by this time. The remaining simpler types of polygonal masonry, when the stones are small or the fitted surfaces are almost flat, or the stones contact each other over a small area, or there are significant gaps between the stones, are quite consistent with the well-known methods of stone processing at that time or earlier, and, therefore, they do not require any additional explanations. The Fortress Sacsayhuaman is considered as an example of early star fortresses that has survived to our time. The polygonal structures in Peru, the polygonal Face Towers and polygonal bas-reliefs in Cambodia, symmetrical statues of pharaohs in Egypt are based on the same construction technologies, working methods, tools and technical contrivances. Therefore, with a high probability one can state that all these monuments were created by the same group of architects, sculptors, builders, and could not have appeared before the 17th century.
Similar Cognitive Skill Impairment in Children with Upper Limb Motor Disorders Due to Arthrogryposis Multiplex Congenita and Obstetrical Brachial Plexus Palsy
Authors: Blagovechtchenski Evgeny , Koriakina Maria , Bredikhin Dimitri , Agranovich Olga , Kadieva Dzerassa , Ermolovich Evgenia , Jääskeläinen Iiro P , Shestakova Anna N
Published: December 2022

Cognitive function, arthrogryposis, obstetrics palsy, children, motor disorder
The Role of Dual-Mobility Components in Total Hip Arthroplasty
Authors: Manson Theodore T. , Adrados Murillo , Gililland Jeremy M. , Mahmood Bilal M. , Samuel Linsen T. , Moskal Joseph T.
Published: December 2022

➤ Dual mobility (DM) refers to a now widely available option for total hip articulation. DM implants feature a small inner head, a hard bearing, that connects via a taper fit onto the femoral trunnion. This head freely rotates but is encased inside a larger, outer polyethylene head that articulates with a smooth acetabular component.

➤ DM acetabular components are available in the form of a monoblock shell or as a liner that is impacted into a modular shell, providing a metal articulation for the polyethylene outer head.

➤ DM is designed to increase hip stability by providing the arthroplasty construct with a higher jump distance, head-to-neck ratio, and range of motion prior to impingement.

➤ The use of DM in total hip arthroplasty continues to increase in the United States for both primary and revision arthroplasty. Surgeons should be aware of the potential benefits and pitfalls.

➤ Long-term data are lacking, especially for modular DM implants. Points of concern include a potential for accelerated polyethylene wear, intraprosthetic dislocation, and modular backside fretting corrosion.
Bava & Leone: The “Spaghettification” of the American Cinematic Form
Authors: Bains Prabhjot
Published: December 2022

In the 1960s two Italian filmmakers, Mario Bava and Sergio Leone, released a string of notable films that directly challenged and re-framed the revered American genres of horror and the western respectively. Their revisualization and ultimate reinterpretation of these traditional genres reached its zenith with the release of Bava’s Black Sabbath (1963) and Leone’s Once Upon a Time in the West (1968). They marked the dawn of a “spaghettification” of the American cinematic form.

This paper argues that the “spaghettification” of the horror and western genres within Black Sabbath and Once Upon a Time in the West redefined the visual calculus of these American genres and revitalized their core tenets, cementing a new cinematic approach to them. Their use of cinematic close-ups, operatic scores, technicolour cinematography, and subversion of the American icon through the casting of Boris Karloff and Henry Fonda established a bold new cinematic style that reshaped the classic American form. This analysis will also note that the motivation behind this visual reformulation was wholly divergent, as Bava embraced his low-budget circumstances to relish the absurdity inherent in the horror genre, while Leone sought to establish a “New West” that was emblematic of the violence and bigotry of the American frontier. The cinematic style of these two films were primarily motivated by a love for the American classics and their revitalization of these classic genres would permeate in the minds of many budding auteurs such as Quentin Tarantino and Martin Scorsese, who in turn would go on to further rejuvenate the American cinematic landscape.

Keywords: Sergio Leone, Mario Bava, Western, Horror, Italian, American, Cinema
Idiopathic Ventricular Tachycardia: Good Prognosis but Debilitating Symptoms
Authors: Simu Gelu , Puiu Mihai , Cismaru Gabriel , Gusetu Gabriel , Pop Dana , Zdrenghea Dumitru , Rosu Radu
Published: December 2022

Ventricular arrhythmias may occur in patients without anatomical heart abnormalities, a condition that is known as idiopathic ventricular arrhythmias. The most common form originates at the level of the outflow tracts. It can manifest as PVCs, non-sustained ventricular tachycardia (VT), and sustained VT. A 52-year-old female patient was admitted for 2 episodes of syncope related to a high burden of premature ventricular contractions (PVCs) and several episodes of VT with the same QRS morphology as the PVCs. A diagnosis of sustained monomorphic VT was formulated in a patient with no structural heart disease and a normal ejection fraction. Antiarrhythmic drugs such as metoprolol, propafenone, and amiodarone failed to reduce the number of PVCs, hence catheter ablation was suggested to the patient. The patient consented to the treatment, and following catheter ablation, the patient no longer experienced syncope. The 24-hour Holter ECG monitoring revealed no PVCs or VTs. PVCs and VTs from the RVOT are typically benign with a good prognosis. Catheter ablation should be employed as the definitive treatment for RVOT-VT, as our case demonstrates only partial response to antiarrhythmic drugs.
Assessment of the Relationship between Expressions of CD34, p63 with Different Clinical Types of Oral Epithelial Dysplasia: A Retrospective Immunohistochemical Study
Authors: Abdulhussain Mustafa , Alaswad Fawaz
Published: December 2022

Background: Potentially malignant disorders such as leukoplakia and erythroplakia are often associated with dysplastic changes that have an increased risk for malignant transformation. CD34 is considered as an important marker for tissue vascularization, which represents microvessel density. P63 has a role in epithelial proliferation and is frequently altered in dysplasia and associated with tumorigenesis. The aim of this study was to evaluate the expression of CD34 and p63 in different grades of oral epithelial dysplasia (OED). Methods and Results: This research included 50 histopathologically confirmed OED. CD34 and P63 expressions were studied by using the immunohistochemical technique. Most OED lesions were observed in patient between 40 and 69 years of age. Buccal mucosa was the most affected site (42%). According to histopathological grades, mild OED was predominant (54%). There was a significant difference among OED grades through the P63 marker. Conclusion: The P63 marker can be considered a good indicator for malignant transformation by grade scoring scales, and the CD34 marker can be used as a useful diagnostic indicator for OED.
Serum Level of Il-2 in Patients with Type 2 Diabetes Mellitus and Periodontopathy
Authors: Bunjaku V , Popovska M , Spasovski S , Spasovska-Gjorgovska A , Barani M , Mrasori Sh
Published: December 2022

The purpose of this study was to investigate the influence of low-level laser therapy (LLLT) in patients with type 2 diabetes mellitus (T2DM) and chronic periodontopathy (ChP) on serum levels of IL-2. Methods and Results: A total of 80 patients aged 35-60 years were followed; all of them had T2DM diagnosed (HbA1C≤7.5%) with ChP, where clinical attachment loss (CAL) was ≥4mm on at least 50% of affected teeth. All participants are divided into two groups. Group A included 40 patients who underwent conservative (non-surgical) periodontal treatment supplemented with LLLT. Group B included 40 patients who underwent only conservative therapy. Patients used oral antidiabetic medications to control glycemia: Metformin (Alkaloid, Skopje S. Macedonia) 500 mg two times a day. LLLT (Laser HF® comfort, Hager. Werken, Duisburg, Germany) was applied (660 nm, 10 mW, 8 min/day) with contact to the gingiva for five consecutive days. Serum IL-2 was determined by ELISA in 3 time intervals: at the first examination, 6 weeks, and 3 months after treatment in both groups. In Group A and Group B, at the first examination, 6 weeks after therapy, and 3 months after treatment, the serum IL-2 was 17.20±0.54 pg/ml and 17.22±0.66 pg/ml, 17.12±0.63 pg/ml and 17.17±0.63 pg/ml, and 17.03±0.64 pg/ml and 16.98±0.65 pg/ml, respectively. In Group A, there was a significant difference between the serum IL-2 values in specified time points (first examination, 6 weeks, and 3 months after the therapy) (Friedman’s ANOVA: χ² (n=40, df=2) = 17.22 and P=0.0002). In Group B, between the serum IL-2 levels, there also was a significant difference in specified time points (Friedman’s ANOVA: χ² (n=40, df=2) = 42.33 and P=0.0000). The intergroup analysis, according to the temporal dynamics of the measurements, showed an evident difference between the two groups, but the serum IL-2 values in the two groups treated with and without LLLT were close, and no statistical significance was recorded between them. Conclusion: No significant differences were recorded in the serum IL-2 levels in T2DM patients with ChP non-surgically treated with and without the application of LLLT.
Bioethical Knowledge and Attitudes Among Dental and Medical Students in the Medical Faculty, University of Prishtina
Authors: Haliti Fehim , Haliti Dion , Hyseni Valon , Haliti Valdete , Hajdari Elena , Haliti Dea , Haliti Naim
Published: December 2022

The importance of bioethics as a formal subject has been recognized globally. The purpose of this study was to analyze undergraduate medical and dental students’ knowledge, practice and attitudes regarding bioethical questions through a questionnaire. This cross-sectional study was conducted among students from the Medical Faculty who were in their first or fourth year of education. There were no differences in bioethics awareness between direction (general medicine [GM] or dentistry) or years of study among 301 GM and dental students. In this research, GM and dental students, in general, indicated a positive attitude and knowledge of bioethics.
Dam and Levee Safety Risk during Remedial Construction
Authors: Schaefer Jeffrey A.
Published: December 2022

Structural modifications to dams and levees can create life safety risks during the construction period. It is important for all parties involved to understand the potential risk, evaluate methods to mitigate risk, and consider the risk when making decisions. Most importantly, it is critical to always strive to “do no harm” and prevent activities that could potentially increase risk. This case history will provide examples of conditions that can lead to increased risk during construction including excavations that lower the crest of a dam or levee, excavations at the toe of an embankment, rapid embankment construction, blocked bypass tunnels, spillway modifications, excavations for outlet culverts, and damage from grouting. A key component of many construction projects is a temporary cofferdam to protect the work area from flooding. Cofferdams have a high potential to create risk during construction. An important step to help prevent increasing risk during construction is to have multiple constructability reviews during the development of the project design. If the potential for construction risk is properly identified, the risk can often be mitigated or reduced. Decision-maker involvement is necessary to assure risks are understood and proper decisions can be made. Several case histories are presented to demonstrate how risks during remedial construction are evaluated and incorporated into decision-making.
Editorial
Authors: Dai David Wei , Grieve Averil , Yahalom Sharon
Published: December 2022

Interactional competence (IC) is a concept gaining growing currency in language learning, teaching and assessment. First proposed by Kramsch (1986), IC focuses on developing second language (L2) speakers’ abilities to use language for functional purposes, ranging from “survival as a tourist or a student to negotiating treaties” (p. 366). The conceptualization of language competence as an ability for use differentiates IC from traditional understanding of proficiency, which consists of componential, de-contextualized ability indicators such as lexical range, grammatical soundness, and pronunciation. The ethos of IC emphasizes that language teaching education needs to focus on cultivating L2 speakers’ abilities to use their linguistic resources (e.g., vocabulary and grammar) to achieve meaningful social actions in real-world interactional contexts. This special issue comprises three research articles and three book reviews, each of which exemplifies the ways in which IC can be applied to face-to-face and online learning opportunities for L2 speakers.
Development of India Meteorological Department - High Resolution Rapid Refresh (IMD-HRRR) Modeling System for Very Short Range Weather Forecasting
Authors: Srivast Akhil , Kumar Prashant , Panda Sambit Kumar , Das Ananda Kr. , Pattanaik D. R.
Published: December 2022

The aim of this study is the operational dynamical nowcasting application over different parts of India from Indian Meteorological Department (IMD) using Doppler Weather Radar (DWR) network of multiple radars and numerical weather prediction (NWP) model. The High Resolution Rapid Refresh (HRRR) approach has been adopted to achieve this objective in which the DWR data are hourly assimilated at convective-scale in the Weather Research and Forecasting (WRF) model. The designated NWP setup implemented for very short-range to nowcasting of weather is defined as the IMD-HRRR modelling system. Various quality controls are employed before assimilating DWR data in the IMD-HRRR system. Three different domains are specified over India that cover the entire Indian landmass, and next 12-hours predictions are provided from hourly cyclic assimilation experiments. The results of all domains suggested that the IMD-HRRR predictions are not degraded with forecast lengths (upto 12 hours) when compared against observations e.g. Synop, Metar, Buoy, total precipitable water (TPW) from GPS stations. Minimum errors are achieved when model predictions are compared against Buoy and TPW observations. The correlation values are higher than 0.9 for all domains. Furthermore, the IMD-HRRR model forecasts are also compared with observed DWR radial winds to demonstrate auxiliary applications of the DWR data for model verifications at high spatio-temporal resolution.
Adaptive Dimensional Search Based Orthogonal Experimentation SSA (ADOX-SSA) for training RBF Neural Network and optimal Feature Selection
Authors: Mahapatra Ajit Kumar , Panda Nibedan , Pattanayak Binod Kumar
Published: December 2022

Salp Swarm Algorithm (SSA) is a new stochastic approach for solving optimization issues based on the ideas of swarm intelligence. The ease of implementation and lower number of parameters to fine-tune are responsible for SSA's success and universal acceptance among researchers. The typical SSA method suffers from local optima entrapment and a poor convergence rate while dealing with more complex situations because of a lack of population density and inadequate local exploitation. To overcome such challenges, this study suggests a hybrid kind of SSA called Adaptive-Dimensional-Search based Orthogonal Experimentation SSA (ADOX-SSA). Furthermore, the inclusion of an ADOX operator increases population diversity, intensifies local exploitation, and strengthens the SSA standards. Consequently, the balance between the processes of exploration and exploitation is attuned, resulting in a faster rate of convergence than the normal SSA. To validate the ADOX-SSA technique's competency, 14 basic functions and 30 advanced standard functions were chosen following IEEE-CEC-2014. The findings of the proposed strategy have also been compared to those of recent metaheuristic approaches. Two nonparametric tests were employed to demonstrate statistical significance as Friedman and Holms approach. Additionally, the suggested ADOX-SSA approach is castoff for training Radial Basis Function Neural Network (RBFNN) by selecting datasets from the UCI depository. Finally, the same suggested approach is utilized to select the best features from benchmark datasets while maintaining accuracy and minimizing neural network complexity.
Green Innovation, Globalization, Financial development and CO2 Emissions: The role of Governance as a moderator in South Asian Countries
Authors: Naz Ayesha , Aslam Misbah
Published: December 2022

The current study is designed to analyze the relationship between, environmental innovations, globalization, financial development, and CO2 emissions in the South Asian region over the period of 1996 to 2019. In this regard, the role of governance is also incorporated as a moderator along with Environmental Kuznets Curve (EKC) hypothesis. The sample size includes Bangladesh, India, Pakistan, Nepal, and Sri Lanka. The results of robust least square show the validity of EKC in the sample countries. Environmental innovations show desirable results on CO2 emissions, while globalization, financial development, and governance are increasing environmental degradation. The role of governance as a moderator is only effective and favorable with environmental innovation. However, in the case of globalization and financial development, governance is appeared to be ineffective in lessening the rate of emissions rather it contributes to emissions. It is clearly showing the missing link in formulating coherent policy to achieve sustainability targets. Therefore, it is desirable to improve the role of governance with respect to environmental policies not only to handle directly environmental issues but also indirectly while promoting the process of globalization and financial development.
Comparative Effects of Curcumin versus Nano-Curcumin on histological, immunohistochemical expression, histomorphometric, and biochemical changes to pancreatic beta-cells and lipid profile of Streptozocin induced diabetes
Authors: Metawea mohamed r. , Abdelrazek Heba M A , El-Hak Heba Nageh Gad , Moghazee Mona m. , Marie Ohoud
Published: December 2022

Diabetes mellitus is a worldwide problem characterized by hyperglycemia as well as the damage of the microscopic structure of the beta-cells of Langerhans pancreatic islets. In the present study, the histological, immunohistochemical, morphometric, and biochemical alterations to pancreatic beta-cells in streptozocin (STZ) induced diabetes were assessed in rats treated with Curcumin (CU) or Nano-Curcumin (nCU). Twenty-four adults male Wistar albino rats were distributed into four groups: the nondiabetic control group, the diabetic untreated group, and two diabetic groups treated with CU or nCU, respectively. Blood glucose, serum insulin levels and lipid profile were measured. The pancreatic tissues were collected and processed into paraffin sections for histological and immunohistochemical examination, oxidative stress markers and real time PCR expression for pancreatic and duodenal homeobox 1 (PDX1). The insulin expression in beta-cells was assessed using immunohistochemistry. Morphometrically, the percentage area of anti-insulin antibody reaction and the percentage area of islets cells were determined. STZ-induced deteriorating alteration in beta-cells led to declines in the number of functioning beta-cells and insulin immunoreactivity. In STZ-treated rats, CU and nCU significantly reduced blood glucose concentration while increasing blood insulin level. It also caused a significant increase in the number of immunoreactive beta-cells to the insulin expression and significant reduction of the immunoreactive beta-cells to the caspase-3 expression. In conclusion, CU and nCU could have a therapeutic role in the biochemical and microscopic changes in pancreatic beta-cells in diabetes induced rats through STZ administration with more bio-efficacy of nCUR.
Assessing the effectiveness and implementation of a universal classroom-based set of educator practices to improve preschool children's outcomes: Protocol for a cluster randomized controlled type 2 hybrid trial in Singapore
Authors: Tan Evelyn Siyun , McLeod Bryce D. , Mildon Robyn A. , Shlonsky Aron , Seah Cheryl K.F. , McCrickerd Keri , Goh Esther , Kembhavi Gayatri
Published: December 2022

Background
Providing high-quality early childhood care and education is widely understood as key to maximizing children's potential to succeed later in life, as it equips young children with the essential skills and competencies needed for their development. Despite the government's efforts to support the early childhood sector, educators in Singapore continue to report difficulties in implementing practices in classrooms that promote children's social, emotional, and cognitive development. To enhance educators' skills in these domains, we developed the Enhancing and Supporting Early development to better children's Lives (EASEL) Approach, a set of universal, educator-delivered practices for use with 3-6-year-old children to improve social, emotional, behavioral, and executive functioning (SEB+EF) outcomes.
Methods
This study will evaluate the implementation and effectiveness of the EASEL Approach in improving early childhood educators' teaching practices and, in turn, children's SEB+EF outcomes. We will conduct a cluster randomized controlled trial that utilizes a type 2 hybrid implementation-effectiveness design in 12 childcare centers. We will use the EPIS (Explore, Prepare, Implement, Sustain) Framework to support the implementation of the EASEL Approach. Implementation strategies include training, educator self-assessments, practice-based coaching, and data monitoring. Primary outcomes include educators' teaching practices and their adoption of the EASEL Approach in everyday practice. Secondary outcomes include the acceptability and feasibility of the EASEL Approach and children's SEB+EF outcomes. Quantitative and qualitative data will be collected at baseline, six months, and after implementation.
Conclusion
Findings from this study will provide important evidence on the implementation of the EASEL Approach in early childhood classrooms in Singapore and the effectiveness of the EASEL Approach in improving educators' teaching practices and children's SEB+EF outcomes.
Trial registration
This study was prospectively registered on ClinicalTrials.gov, Identifier: NCT05445947 on 6th July 2022.
Interference coordination algorithm based on disturbance code
Authors: chen xiaoqing , feng ziliang
Published: December 2022

With the development of wireless network and the improvement of spectrum space reuse, the same-frequency interference becomes the bottleneck restricting the performance of wireless communication system, which will inevitably reduce the network performance and user service quality. Same-frequency network is an unavoidable problem in wireless communication. How to more effectively restrain or coordinate the interference of the same-frequency critical interval has become a long-term problem. Although the traditional SFR successfully coordinates the interference between the neighbors, it also fragments the use of wireless resources, increases the complexity of resource scheduling, and affects the throughput of the system. Therefore, this paper proposes a purpose of focusing on the edge users of adjacent cells; to ensure that the disturbances of the edge users of adjacent cells are orthogonal to each other and do not affect each other to resolve their own signals. In order to reduce the interference of edge users to the adjacent communication, improve the throughput and wireless resource utilization of the entire wireless communication system.
UV 20W-class single-mode nanosecond pulse delivery using a vacuum-free/ambient air inhibited-coupling hollow-core fiber
Authors: LEROI FLORIAN , GÉRÔME FRÉDÉRIC , DIDIERJEAN JULIEN , SABY JULIEN , BENABID FETAH , BOULLET JOHAN
Published: December 2022

Silica fibers have been successful used to deliver high-power high-energy laser beam in the near-infrared and visible range but suffer from high absorption and color formation in the UV spectrum which disqualify then for such wavelength. Recently, the advances of inhibited-coupling hollow-core photonic crystal fibers made them as an unique tool to transport UV radiation thanks to an ultralow overlap with the silica cladding and record losses down to 10 dB/km. By further optimizing such fiber, we report in this letter a record single-mode delivery of 23.3 W (155 μJ) with 92% transmission from a 343 nm, 10 ns, 150 kHz laser source, corresponding to an improvement of the current state-of-the-art by two orders of magnitude. © 2022 OpticaPublishing Group
What is Appropriate? On the Assessment of Human-Robot Proxemics for Casual Encounters in Closed Environments
Authors: Neef Nicolas Eric , Zabel Sarah , Lauckner Mathis , Otto Siegmar
Published: December 2022

Autonomous robots of different kinds become more and more salient in our everyday life and because the spatial proximity of robots has an effect on the well-being of humans, researchers try to find and give appropriate guidelines regarding spatial proximity. In doing so, these studies rely on a few different concepts (e.g., safety or comfort) and on a rather large variety of different measurement approaches thereof. From psychology we know that the conceptual framing, as well as the way we measure (number of items, labels of scales, and wording) can affect the outcome of such studies. We present the first study that addresses and evaluates the consequences of these different conceptual and methodological approaches. We found that there is significant interaction between the different measurement approaches and the determined appropriate distance. This interaction was significant for both lateral passing distances and frontal approaches. This can have real-life effects, since the appropriate distances determined in studies such as the present may directly influence actual programming algorithms. Furthermore, by using three different types of robots, we were able to show that the humanization of mechanoids can lead to the acceptance of smaller distances by humans.
A prediction and fuzzy-based approach for VM migration for optimal trade off energy-performance in cloud network
Authors: Zolfaghari Rahmat
Published: December 2022

Energy efficiency, low utilization of Physical Machines (PM) and service access level are challenges of cloud networks, while efficient migration of Virtual Machines (VMs) is a solution for them. Uncontrolled migration of the VMs can causes migration overhead, that most important of them comprising: violation in Service Level Agreement (SLA) and high energy consumption. Generally, performance requirements in the form of SLAs are formalized. The main goal of the dynamic migration of VMs is a trade-off in energy and performance. Detecting when cloud's PMs is being overloaded or under-loaded are two substantial sub-problems of dynamic VM migration, which directly effects the performance and energy efficiency. Thus, migration technique is a practical approach for balancing the electricity consumption and Quality of Service (QoS) requirements in the cloud networks. In this paper, with definition an architectural framework in the system modelling, in first to detect overloaded and under-loaded PMs a Predict Detection method (PD method), and then for selection of VMs on overloaded PMs a Fuzzy Selection method (FS method), in overall, algorithm (PDFS) is proposed. The algorithm PDFS simulation results demonstrate that the proposed algorithm significantly outperforms benchmark algorithms in terms of energy, migration overhead, service access and SLA violation.
F10-AS1/hsa-miR-146b-5p/RAD54L axis regulates the progression of gastric cancer by mediating homologous recombination pathway
Authors: Zhou Ying , Geng Yan , Guo Xianling
Published: December 2022

Radiation resistance and the etiology of gastric cancer (GC) is significantly influenced by the DNA damage response, particularly DNA double-strand breaks (DSBs). A repair method for dealing with DNA damage is homologous recombination repair (HRR). The stability of the genome may be directly harmed by the homologous recombination deficiency (HRD) or blockage of the HRR pathway, inducing a slight increase in chromosome aberration and eventually leading to malignant tumors, including gastric adenocarcinoma. Therefore, to clarify the mechanism of DNA damage repair and create GC therapeutic targets, it is crucial to investigate the feedback mechanism of HRR to DSB in GC. Through bioinformatics analysis, the differentially expressed genes related to GC were found, the core genes were screened by the WGCNA method, the ceRNA network F10-AS1/hsa-miR-146b-5p / RAD54L was predicted and constructed by mirDIP and LncBase database, and the inhibitory effect of knockdown F10-AS1 on RAD54L was verified by in vivo and in vitro experiments. Results exhibited that knockdown of F10-AS1 raised the inhibitory effect of F10-AS1 on hsa-miR-146b-5p, promoted the combination of miR-146b-5p and RAD54L, downregulated the expression of RAD54L, and induced GAC cell death in vitro and slowed tumor growth in vivo. In the HR route of DNA repair, the F10-AS1/hsa-miR-146b-5p/RAD54 axis is crucial. Knockdown of F10-AS1 means that it inhibits homologous recombination in cancer cells and the maintenance efficiency of the DNA repair mechanism, induces the accumulation of spontaneous DSB, blocks DNA repair in cancer cells, achieves the best effect of anticancer drugs, and inhibits tumor development.
Two Improving Approaches for Faulty Interaction Localization using Logistic Regression Analysis
Authors: Nishiura Kinari , Choi Eun-Hye , Choi Eunjong , Mizuno Osamu
Published: December 2022

Faulty Interaction Localization (FIL) is a process to identify which combination of input parameter values induced test failures in combinatorial testing. An accurate and fast FIL provides helpful information to fix defects causing the test failure. One type of conventional FIL approach, which analyzes test results of whole test cases and estimates the suspiciousness of each combination, has two main concerns; (1) the accuracy is not enough, (2) the huge time cost is sometimes needed. In this paper, we propose two novel approaches to improve those concerns. FROGa attempts to estimate suspiciousness more accurately using logistic regression analysis. FROGb attempts to estimate failure-inducing combinations at high speed by estimating the subsets of them using logistic regression analysis and exploring just their supersets. Through evaluation experiments using a large number of artificial test results based on several real software systems, we observed that FROGa has very high accuracy, and FROGb can drastically reduce time cost for targets that have been difficult to complete by the conventional method.
Bio-medical Image Restoration Using Hybrid Hyperspectral Images Deep Learning With MMA
Authors: Latchoumi T. P. , Senthilselvi A. , chelliah Balika J
Published: December 2022

Photothermal Therapy (PT) is an efficient scanning technique in biological research. However, rapid PT scanning and noise attenuation constitute a critical challenge in a clinical trial. To solve this problem, techniques based on Compression Sensors (CS) have recently been developed that use lower PT calculation costs and excellent accuracy. The majority of image results of prominence techniques depends on rare and inconsistent circumstances. It also takes considerable time to ensure that the photothermal information gathered empirically meets CS requirements. To address these constraints, a Hyperspectral Images Deep Learning (HSIDL-PT) and Maximize-Minimize Algorithm (MMA) method proposed in this paper to efficiently reduce under-represented artifacts in Neural Network (NN). The proposed method is to retrieve high photothermal images which used 5% of the total measuring information. Furthermore, the quantitative evaluation shows that the s HSIDL-PT technique improves performance by 30 percent when compared to the existingZ technique. with mean Structure Similarity Index (SSIM) = 0.974, Peak Signal-to-Noise Ratio (PSNR) = 29.88 dB and Standard Deviation of ± 0.007. Researchers propose MMA with Deep Learning, which would be the outcome of employing the limit for non-convex optimization, ethical and responsible that used the unifying MMA viewpoint; studies demonstrate that the proposed method outperforms the only one depending on linear maximizing.