bluuebunny/crossref_metadata_2025 huggingface dataset:
The crystal structure of zwitterionic 3-aminoisonicotinic acid, C6H6N2O2
Authors: Wang Xinsheng , Wang Xiuge
Published: March 2024

C6H6N2O2, monoclinic P21/c (no. 14), a = 6.7909(2) Å, b = 23.9261(7) Å, c = 7.5103(2) Å, β = 95.265(2)°, V = 1215.12(6) Å3, Z = 8, R
gt(F) = 0.0574, wR
ref(F
2) = 0.1439, T = 293.
Is there hyper-raising in European Portuguese?
Authors: Gonçalves Anabela , Colaço Madalena
Published: March 2024

Several languages allow for hyper-raising, a structure in which a DP that is interpreted as the subject of a finite complement clause is spelled-out as the subject of the matrix clause. Hyper-raising challenges certain core concepts of syntactic theory related to movement and locality. Various proposals have been made for analysing these structures, the main difference being whether the final position of the DP results from movement or not. It has often been assumed that European Portuguese, in contrast to Brazilian Portuguese, does not allow hyper-raising, or only allows it in very limited contexts. In this paper, we present empirical data extracted from written corpora and experimental results attesting to the production and acceptance of hyper-raising structures by a number of native speakers of European Portuguese. We contribute to identifying the contexts that favour hyper-raising in this variety and outline a preliminary analysis to explain what leads these speakers to produce and accept hyper-raising, while many others systematically reject it. In our proposal, this difference results from the properties of the embedded functional heads T and C, and the way in which their formal features are checked. Specifically, we propose that those speakers dissociate Case features from person-number features.
Identification of GPR35-associated metabolic characteristics through LC-MS/MS-based metabolomics and lipidomics
Authors: Zhang Qiqing , Zhao Xian , Qin Siyuan , Xiao Qinwen , Tian Yuan , Zhang Zunjian , Zhang Pei , Xu Fengguo
Published: March 2024

G protein-coupled receptor 35 (GPR35) has gained increasing attention as a promising target in treating inflammatory and gastrointestinal tract conditions, cardiovascular diseases, and cancer. Metabolites including kynurenic acid, lysophosphatidic acids, chemokine 17, and 5-hydroxyindole acetic acid have been suggested to be endogenous ligands of GPR35. However, little is known regarding the downstream metabolic characteristics upon GPR35 regulation. Herein, four GPR35 interventions in cell models, comprising GPR35 knock-down, over-expression, activation, or inhibition, were established through lentiviral transduction, or the use of a potent agonist (pamoic acid) or antagonist (ML194). Targeted metabolomics and pseudotargeted lipidomics were performed on these cell models to capture GPR35-associated metabolites and lipids. Levels of 75 metabolites and 204 lipids were significantly altered in response to one or more GPR35 interventions. Levels of metabolites involved in fatty acid β-oxidation and phosphatidylethanolamine metabolism were notably altered. This study reports the first exploration of the metabolic characteristics of GPR35, and may aid in understanding of the potential mechanisms and functions of GPR35 in various physiological and pathological conditions.
Neurochemical Predictors of Generalized Learning Induced by Brain Stimulation and Training
Authors: Ehrhardt Shane E. , Wards Yohan , Rideaux Reuben , Marjańska Małgorzata , Jin Jin , Cloos Martijn A. , Deelchand Dinesh K. , Zöllner Helge J. , Saleh Muhammad G. , Hui Steve C. N. , Ali Tonima , Shaw Thomas B. , Barth Markus , Mattingley Jason B. , Filmer Hannah L. , Dux Paul E.
Published: March 2024

Methods of cognitive enhancement for humans are most impactful when they generalize across tasks. However, the extent to which such “transfer” is possible via interventions is widely debated. In addition, the contribution of excitatory and inhibitory processes to such transfer is unknown. Here, in a large-scale neuroimaging individual differences study with humans (both sexes), we paired multitasking training and noninvasive brain stimulation (transcranial direct current stimulation, tDCS) over multiple days and assessed performance across a range of paradigms. In addition, we varied tDCS dosage (1.0 and 2.0 mA), electrode montage (left or right prefrontal regions), and training task (multitasking vs a control task) and assessed GABA and glutamate concentrations via ultrahigh field 7T magnetic resonance spectroscopy. Generalized benefits were observed in spatial attention, indexed by visual search performance, when multitasking training was combined with 1.0 mA stimulation targeting either the left or right prefrontal cortex (PFC). This transfer effect persisted for ∼30 d post intervention. Critically, the transferred benefits associated with right prefrontal tDCS were predicted by pretraining concentrations of glutamate in the PFC. Thus, the effects of this combined stimulation and training protocol appear to be linked predominantly to excitatory brain processes.
Numerical simulation of Sb2Se3-based solar cells
Authors:   School of Physics and Materials Science, Nanchang University, Nanchang 330031, China, Liu S. H. , Yuan J. R. ,   School of Physics and Materials Science, Nanchang University, Nanchang 330031, China, Wu Y. ,   School of Physics and Materials Science, Nanchang University, Nanchang 330031, China, Deng X. H. ,   School of Physics and Materials Science, Nanchang University, Nanchang 330031, China, Yu Q. M. ,   School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, China
Published: March 2024

Antimony selenide (Sb2Se3) has remarkable optoelectronic capabilities that make it a promising option for the next generation solar cells. In this work, a solar cell with the structure Al/FTO/CdS/Sb2Se3/Mo is modeled and numerically analyzed using SCAPS-1D program. Furthermore, a Al/FTO/CdS/Sb2Se3/Sb2S3/Mo solar cell structure that uses Sb2S3 as the back surface field (BSF) layer is proposed. A comprehensive examination of photovoltaic characteristics for the solar cells was carried out. The optimization process involved adjusting the operating temperature, series and shunt resistance, doping concentration, bulk defect density, back contact metal work function, and thickness of the absorber layer. The optimized Sb2Se3-based solar cell with Sb2S3 material showed a conversion efficiency of 28.91%, suggesting that Sb2Se3-based solar cells have a great deal of potential for further development.
The Vital Role of Legal Education in Societal Transformation: Fostering Legal Awareness and Social Justice
Authors: Pradanna Satrio Alpen , Irawan Hendri
Published: March 2024

This article explores the crucial role of legal education in societal transformation, with a specific focus on fostering legal awareness and promoting social justice. The introduction highlights the inherent interconnectedness of individuals in communal living and emphasizes law as a dual-aspect phenomenon governing legal subjects. The research aims to analyze the multifaceted functions of law, such as social control, engineering, symbolism, politics, and integration, to contribute to shaping a balanced and just society. The paper also delves into the objectives of legal education, intending to cultivate responsible citizens with a comprehensive understanding of legal awareness. Employing a qualitative approach through an extensive literature review, the methodology focuses on studying existing scholarly works. The article advocates for integrated efforts to realize legal transformation and societal harmony through robust legal education initiatives. In conclusion, it underscores the need for a collective commitment to fostering legal awareness for a more just and harmonious society
Unleashing the Power of Class Action Lawsuits: Redefining Justice for Insurance Policyholders in Indonesia
Authors: Haryanto Imam , Suherman Suherman , Sakti Muthia , Khalilullah Ibrahim Hanif
Published: March 2024

This paper explores the transformative potential of class action lawsuits in redefining justice for insurance policyholders in Indonesia. Through an in-depth examination of the legal landscape and specific cases, the study delves into the mechanisms and implications of leveraging class actions as a means of seeking justice within the insurance sector. By analyzing notable instances, such as the class action lawsuit initiated by insurance policyholders of PT Asuransi Jiwasraya and PT Asuransi Jiwa Adisarana WanaArtha, the paper scrutinizes the impact of collective legal action in addressing grievances and restoring violated rights. The research also navigates the legal provisions surrounding class actions in Indonesia, shedding light on their relevance and effectiveness in the pursuit of justice for insurance policyholders. Ultimately, this paper contributes to the ongoing discourse on legal remedies within the insurance industry, offering insights into the potential of class action lawsuits as a powerful tool for policyholders to assert their rights and demand justice in the Indonesian legal context.
Interpreting Article 22(2) of the 1945 Constitution of the Republic of Indonesia Post Constitutional Court Decision 54/PUU-XXI/2023
Authors: Riqiey Baharuddin , Huda Muhammad Ahsanul
Published: March 2024

The aim of this research is to elucidate the interpretation of Article 22, paragraph (2) of the 1945 Constitution of the Republic of Indonesia, particularly focusing on the phrases "obtain approval from the House of Representatives" and "in the following trial." Employing a normative legal research approach, the study utilizes a statutory regulatory approach, a conceptual approach, and a case approach. The legal materials encompass both primary and secondary legal sources. The research findings delineate that the phrase "obtain approval from the People's Representative Council" in Article 22, paragraph (2) of the 1945 Constitution of the Republic of Indonesia signifies: (i) the requirement for the President to submit the Perppu to the DPR for approval; and (ii) the discretion of the DPR to either approve or disapprove the Perppu. Meanwhile, the interpretation of the phrase "in the following trial" entails: (i) the period during which the Perppu is submitted to the DPR by the President; (ii) the initial session of the DPR following the submission of the Perppu; and (iii) the initial session period after the expiration of the maximum time limit for the President to submit the Perppu to the DPR.
Bilgi paylaşımının erdemli raporlama (whistleblowing) üzerindeki etkisinde birey-örgüt uyumunun aracılık rolü
Authors: Altıntaş Mustafa , Turan Ayşegül
Published: March 2024

Bu araştırmanın amacı örgütlerde bilgi paylaşımının erdemli raporlama (whistleblowing) üzerindeki etkisinde birey- örgüt uyumunun aracılık rolünün belirlenmesidir. Çalışma erdemli raporlamaya karşı farkındalık oluşturmak açısından önemlidir. Nicel araştırma deseninin benimsendiği çalışmada örneklemi, Kırşehir’de faaliyet gösteren küçük, orta ve büyük ölçekteki işletmelerde çalışanlar oluşturmaktadır. Kolayda örnekleme yöntemiyle ulaşılan 448 kişiyle, çevrimiçi anket yoluyla veriler toplanmıştır. Toplanan verilerin analiz edilmesinde kısmi en küçük kareler yol analizi (PLS-SEM) tercih edilmiş olup Smart-PLS istatistik programı kullanılarak analiz gerçekleştirilmiştir. Araştırma verilerinden elde edilen bulgulara göre bilgi paylaşımı tutumunun erdemli raporlama üzerindeki etkisinde birey-örgüt uyumunun aracılık rolü bulunamamıştır. Bunun yanı sıra bilgi paylaşımının birey-örgüt uyumu üzerinde pozitif yönlü ve anlamlı etkisi ile birey-örgüt uyumunun erdemli raporlama üzerinde pozitif yönlü ve anlamlı etkisi bulunmaktadır. Elde edilen sonuçlar örgütlerde uygulanan bilgi paylaşımı tutumunun ve birey- örgüt uyumunun etik dışı sonuçları açığa çıkarmada etkisi olduğunu göstermektedir. Çalışanların olumlu bilgi paylaşımı tutumları onların birey- örgüt uyumlarını iyileştirmekte, birey- örgüt uyumu iyileştikçe erdemli raporlama davranışına olan meyilleri artmaktadır. Çalışanların olumlu bilgi paylaşımı tutumları erdemli raporlama davranışına teşvik ederken, bireyin çalıştığı örgütle olan uyumu bu teşviki artırmamaktadır. Bu durumun tersine çalışanların olumsuz bilgi paylaşımı tutumları, erdemli raporlama davranışından kaçınmayı teşvik ederken, bireyin çalıştığı örgütle olan uyumsuzluğu bu teşviki artırmamaktadır. Çalışandaki, erdemli raporlama davranışının kültürel olarak olumsuz algı yaratmasına yönelik kaygıların, bireyin örgütle uyum veya uyumsuzluğundan bağımsız geliştiğini ve bu nedenle aracılık rolünün bulunmadığını ifade etmek mümkündür.
Why Principal Positive Leadership Is Important: It’s Mediating Effect on the Relation between the School Context and Student Academic Achievement
Authors: Zhang Xinping
Published: March 2024

“Deficit remediation” as an educational governance paradigm has given rise to many problems, whereas principal positive leadership under the “strengths development” paradigm has the potential to give new impetus to school development. Based on large-scale survey data within a provincial region, this study investigates how the school context and principal positive leadership impact student academic achievement using structural equation models. Research findings show that principal positive leadership as a structural latent variable has positive impacts on student academic performance and significantly mediates the effects of the school context on student academic results; and that the patterns of the impacts of principal positive leadership differ according to the variations of the school’s autonomy in operation.
Unternehmensbesteuerung und Rechtsform
Authors: Marx Franz Jürgen
Published: March 2024

Die Fallstudie ermöglicht einen verständlichen und überschaubaren Einblick in die Bestimmung der Steuerbelastung von Unternehmen in Deutschland. Im Unterschied zu einer gesamtwirtschaftlichen Betrachtung werden die für ein unternehmerisches Engagement in Betracht kommenden Steuerbelastungen identifiziert und im Beispiel anhand gegebener Daten für verschiedene Rechtsformen quantifiziert. Zugleich bietet die Fallstudie die Möglichkeit zur Auseinandersetzung mit der Notwendigkeit der steuerlichen Rechtsformneutralität und Ansätzen für eine weitere Reform der Unternehmensbesteuerung.
Functional biodiversity and agroecological selfregulation for sustainable food
Authors: Vázquez Luis L
Published: March 2024

Functional biodiversity is a determining factor in the agroecological transformation towards sustainable food systems. The agroecological design and management of productive, associated and auxiliary biodiversity accumulates agroecological self-regulation capacities from the primary production process to food ingestion
Confidence bias, hindsight bias and perceptions of risk in motorcyclists
Authors: Freeman Rod
Published: March 2024

Confidence bias and hindsight bias were investigated as predictors of perceived levels of risk in a sample of motorcyclists. Confidence bias was predictive of both perceived absolute risk and perceived comparative risk. Hindsight bias was predictive of total absolute risk but was only predictive of comparative risk regarding car drivers and not total comparative risk or risk compared to other motorcyclists. In addition, the direction of the relationship with risk perception differed for confidence bias compared to hindsight bias. It appears that confidence and hindsight bias operate through different processes. Personal experience of accidents was not a predictor of perceived risk, but having a friend who had an accident did have an impact.
Improving Accuracy of Medication Reconciliation for Hospitalized Children: A Quality Project
Authors: Gunkelman Samantha M. , Jamerino-Thrush Jennifer , Genet Katherine , Blackford Martha , Jones Kerwyn , Bigham Michael T.
Published: March 2024

BACKGROUND AND OBJECTIVES

Medication reconciliation is a complex, but necessary, process to prevent patient harm from medication discrepancies. Locally, the steps of medication reconciliation are completed consistently; however, medication errors still occur, which suggest process inaccuracies. We focused on removal of unnecessary medications as a proxy for accuracy. The primary aim was to increase the percentage of patients admitted to the pediatric hospital medicine service with at least 1 medication removed from the home medication list by 10% during the hospital stay by June of 2022.

METHODS

Using the Model for Improvement, a multidisciplinary team was formed at a children’s hospital, a survey was completed, and multiple Plan–Do–Study–Act cycles were done focusing on: 1. simplifying electronic health record processes by making it easier to remove medications; 2. continuous resident education about the electronic health record processes to improve efficiency and address knowledge gaps; and 3. auditing charts and real-time feedback. Data were monitored with statistical process control charts.

RESULTS

The project exceeded the goal, improving from 35% to 48% of patients having at least 1 medication removed from their home medication list. Improvement has sustained for 12 months.

CONCLUSIONS

The combination of interventions including simplifying workflow, improving education, and enhancing accountability resulted in more patients with medications removed from their home medication list.
The moderating effect of income inequality in fiscal policy efficiency: The case of Central and Eastern Europe
Authors: Aktaş Emi̇n Efecan
Published: March 2024

One of the objectives of fiscal policy is to ensure a fair income distribution. In the literature there is no consensus on the income inequality – fiscal policy nexus. Unlike previous studies, this paper contributes to the literature by quantifying the moderating effect of income inequality in total tax revenues and gross national expenditures which are defined as fiscal policy tools. With the help of two moderator variables (income inequality*total tax revenues, and income inequality*gross national expenditures), the impact of income inequality and fiscal policy tools on economic growth are tested for 20 Central and Eastern European (CEE) countries from 1990 to 2019. Diagnostic tests are also carried out on the series before long-term relationships are determined. Our analysis finds that the inequality-growth relationship is negative, the moderator variable defined as income inequality * total tax revenues decreases the strength of the relationship, and the moderator variable defined as income inequality * gross national expenditures increases the strength of the relationship.
Beyond Carvings and Rituals: Unveiling the Ikenga's Role in Modern Igbo Society
Authors: Ndubuisi Chinyere
Published: March 2024

Purpose of the Study: This study examines the contemporary significance of the Ikenga, a crucial cultural symbol among the Igbo people of Nigeria, commonly associated with strength, determination, and entrepreneurial drive. Methodology: The study used a qualitative research design and employed semi-structured interviews, participant observation, and document analysis to collect data from various participants in Igbo society. These participants included entrepreneurs, community leaders, cultural historians, and spiritual leaders. Main Findings: The research reveals that Ikenga continues to serve as a significant cultural icon, supporting entrepreneurship and symbolizing communal achievements and personal aspirations in contemporary times. Despite the challenges of globalization, Ikenga adapts to maintain its relevance, underpinning socio-economic practices and embodying the enduring Igbo values of resilience and determination. Applications of this Study: The findings provide valuable insights for policymakers, cultural practitioners, and scholars, highlighting the importance of integrating cultural heritage into development strategies. This study encourages a multidisciplinary approach to understanding the dynamic interplay between traditional symbols and modern societal roles, offering a model for preserving cultural identity in rapidly changing environments. Novelty/Originality of this Study: This research contributes to the ethnographic literature by offering a contemporary analysis of Ikenga's relevance in Igbo society, beyond its traditional and symbolic interpretations. It underscores the symbol's adaptability and enduring significance, enriching the discourse on the preservation of cultural heritage in the face of globalization and modern challenges.
Wolf Soup
Authors: Harvey John
Published: March 2024

A satire by the playwrite John Harvey.
Une Mauvaise Herbe
Authors: Murrell Di
Published: March 2024

An essay about purslane, a member of the Portulacaceae family providing its history, medicinal and culinary properties and recipes.
The Relationship of Low-Serum Vitamin D and Early Dental Implant Failure
Authors: Francis John R. , Barber H. Dexter , Beals Douglas , Siu Trever
Published: March 2024

The study is aimed to assess the effects of serum vitamin D levels and their relationship to early dental implant failures. A total of 174 implants in 109 patients were placed and serum vitamin D levels were noted on the day of implant placement. Implants were followed up until restoration, approximately 3–6 months later, and any implant failure was reported based on 50% or more bone loss or implant mobility. Eight individuals had an implant fail early and their vitamin D levels had a mean of 42.54 ng/mL compared with the successful patients’ levels of 31.92 ng/mL. Although not statistically significant, there was no correlation between patients’ low serum vitamin D levels and early implant failure.
A Survey on ARP Poisoning
Authors: Mehta Suma B , Rengarajan A.
Published: March 2024

This paper's primary goal is to examine the detection and mechanism of ARP spoofing. One may argue that the Address Resolution Protocol, or ARP for simple terms, is crucial to computer science and forensics. ARP spoofing is one of the various computers hacking techniques used nowadays by individuals to transmit phony ARP packets across a Local Area Network (LAN). Such attacks might lead to changes in traffic patterns or, worse yet, a temporary or permanent stoppage of traffic. Even though this attack is only possible on networks with Address Resolution Protocols, ARP spoofing can be a precursor to more dangerous assaults that have the potential to do considerably more harm. An attacker seeking to launch this sort of attack will search for the Address Resolution Protocol's vulnerabilities. He may, for instance, be trying to take advantage of flaws like the message's inability to properly verify the sender. Because of this, hackers may find it very simple to alter or steal users' data. Because ARP spoofing poses a genuine risk to the security of every user on the network, all appropriate precautions must be taken to minimize harm.
The Effects of Technology evolution on Cybercrime
Authors: Nafish Afrin , Rengarajan A.
Published: March 2024

The rapid evolution of technology has revolutionized numerous aspects of modern life, however, it has also resulted in additional challenges, particularly in the realm of cybersecurity. This research paper explores the multifaceted effects of technological evolution on cybercrime. It examines how advancements in technology have both facilitated cybercriminal activities and enabled innovative strategies for cybersecurity. This paper aims to provide insight into the complex interplay between technological progress and cybercrime, ultimately highlighting the importance of proactive measures to mitigate cyber threats in an increasingly digitized world.
Structure of Soft Skills of Future Social Workers
Authors:   Vasyl Stefanyk Precarpathian National University, Mandro Lesia
Published: March 2024

The article is dedicated to the research of soft skills structural units and their formation of future social workers, as well as the issue of their professional growth and development. Professional skills consist of specific knowledge and abilities important for performing a particular job and that can be mostly identified, evaluated and measured. Until now, there was a perception that hard or functional- -technical skills were the only skills needed for career growth and development. However, a study carried out at Harvard University shows that 80% of career achievements are determined by soft (social and communication) skills and only 20% by functional and technical skills. Since the labor market currently requires diverse professionals, higher education institutions face new challenges. One of these challenges is to create pedagogical conditions for the development of soft skills, including those of future social workers. The professional competence of a social worker involves three groups of skills, namely hard skills, soft skills and meta skills. We suppose that the mechanism of their formation in the conditions of professional training should be focused on the development of all components of soft skills, and their development provides the necessary professional qualities, the implementation of abilities, and the realization of values in social work. In accordance with the characteristics of future social workers in the development of «soft skills», its characteristic features and peculiarities are clarified, including: creating an informal environment for the formation of social leadership in higher educational institutions; filling the educational program with options for «soft skills», activities aimed at increasing the practice-oriented training of future specialists, the use of active and interactive techniques, forms, methods and means of developing the «soft skills» of social workers. The results of the study include the definition of the concept of «soft skills», the identification of their general characteristics, the outlining of groups of soft skills, and the description of their main components. It was found that the most in-demand flexible competencies are: teamwork, critical thinking, leadership, creativity, meeting deadlines, responsibility and discipline, as well as communication skills, emotional stability, ability to work in stressful situations, adaptability to a new team or working conditions, conflict resolution, critical and creative thinking, public speaking skills, reliability, flexibility, responsibility, priority setting, planning, adequate perception of criticism and readiness for improvement, and professional etiquette proficiency
CONEXÕES EPIDEMIOLÓGICAS ENTRE TELAS E MOVIMENTO, COMPORTAMENTO SEDENTÁRIO, (IN)ATIVIDADE FÍSICA E HÁBITOS DE SAÚDE
Authors: Santos Marco Antonio Ferreira dos , Albuquerque Bruno Rolemberg de , Nascimento Bruno José , Castro Bruno , Valente Luciano Alonso
Published: March 2024

Este estudo analisou os padrões de atividade física, comportamentos sedentários e exposição a telas em estudantes de quatro unidades escolares no Rio de Janeiro. O objetivo foi fornecer insights para o desenvolvimento de estratégias de promoção da saúde através de atividades físicas e esportes (AFES). Utilizando o questionário IPAQ, foram coletados dados de 1668 estudantes, com idade média de aproximadamente 13.8 anos de todas as séries do ensino fundamental e médio. Testes estatísticos foram empregados para análise.

Os resultados indicaram que os estudantes caminharam, em média, mais de 10 minutos por dia em 4 dias (masculino) e 3 dias (feminino), com 75 minutos (masculino) e 69 minutos (feminino) de caminhada diária, respectivamente. A média de atividades moderadas foi de 91 minutos por dia, enquanto as atividades vigorosas totalizaram, em média, 126 minutos (masculino) e 71 minutos (feminino). Diferenças significativas entre sexos foram observadas na caminhada diária, atividades moderadas e vigorosas, além do tempo de inatividade semanal. Variações também foram identificadas entre as unidades escolares, indicando diferenças na aplicação das AFES.

A correlação positiva e significativa entre o total de dias e o tempo de atividades vigorosas (ρ = 0.65; p ≤ 0.05) destaca a importância de estratégias diferenciadas. No que diz respeito à inatividade e exposição a telas, a média de tempo durante a semana foi de 574 minutos, enquanto nos finais de semana foi de 510 minutos. Esses resultados contribuem para direcionar políticas de promoção da saúde, enfatizando a necessidade de abordagens personalizadas para estudantes no Rio de Janeiro.
DO MAIS EDUCAÇÃO AO NOVO MAIS EDUCAÇÃO: O FINANCIAMENTO DO GOVERNO FEDERAL DO TEMPO INTEGRAL NAS ESCOLAS
Authors: Menezes Janaína Specht da Silva , Diniz Júnior Carlos Antônio , Iglesias Alessandra Fontes
Published: March 2024

O objetivo deste artigo é analisar os mo(vi)mentos do financiamento federal da política de educação em tempo integral, empreendidos a partir da substituição do Programa Mais Educação pelo Programa Novo Mais Educação. De natureza quanti-qualitativa o estudo tem por base a pesquisa bibliográfica, a partir de referenciais teóricos que tratam da educação integral e do tempo integral e alicerçado na pesquisa documental, o artigo examina os documentos editados pelo governo federal que tratam do financiamento dos referidos programas via Programa Dinheiro Direto na Escola. Entre seus resultados, revela, a priori, a marca da descontinuidade nas políticas indutoras da educação em tempo integral no país. Constatou-se que ambos os programas utilizaram o financiamento repassado diretamente às escolas como estratégia de indução à sua implementação e capilaridade nas redes públicas das instâncias subnacionais. Além disso, observou-se que os atrasos no envio dos recursos financeiros contribuiu para a demora no início das atividades do programa bem como para a sua interrupção por parte das escolas.
SENSITIVITY ANALYSES OF A MULTIPHYSICS LONG-TERM CLOGGING MODEL FOR STEAM GENERATORS
Authors: Jaber Edgar , Chabridon Vincent , Remy E. , Baudin M. , Lucor D. , Mougeot M. , Iooss Bertrand
Published: March 2024

Long-term operation of nuclear steam generators can result in the occurrence of clogging, a deposition phenomenon
that may increase the risk of mechanical and vibration loadings on tube bundles and internal structures, as well as
potentially affecting their response to hypothetical accidental transients. To manage and prevent this issue, a robust maintenance program that requires a fine understanding of the underlying physics is essential. This study focuses on the utilization of a clogging simulation code developed by EDF R&D. This numerical tool employs specific physical models to simulate the kinetics of clogging and generates time-dependent clogging rate profiles for particular steam generators. However, certain parameters in this code are subject to uncertainties. To address these uncertainties, Monte Carlo simulations are conducted to assess the distribution of the clogging rate. Subsequently, polynomial chaos expansions are used to construct a metamodel while time-dependent Sobol' indices are computed to understand the impact of the random input parameters throughout the entire operating time. Comparisons are made with a previously published study, and additional Hilbert-Schmidt independence criterion sensitivity indices are calculated. Key input-output dependencies are exhibited in the different chemical conditionings, and new behavior patterns in high-pH regimes are uncovered by the sensitivity analysis. These findings contribute to a better understanding of the clogging phenomenon while opening future lines of modeling research and helping to make maintenance planning more robust.
The role of intrinsic soil properties in the compressive strength and volume change behavior of unstabilized earth mortars
Authors: Meimaroglou Nikiforos , Mouzakis Charalampos
Published: March 2024

Despite the growing interest in earthen construction, there is critical lack of reliable experimental data on the soil properties which mostly affect the engineering characteristics of the dried building material. Therefore, the main objective of this research was to explore the influence of some of these properties, namely clay fraction content, Specific Surface Area (SSA), Cation Exchange Capacity (CEC), chemical and mineralogical composition and various forms of iron and calcium carbonate on earth mortars. The initial trigger for this research was the extraordinary compressive strength of four earth mortars prepared with different soils. So, these four soils, along with seven others from previous research, were thoroughly examined using soil science techniques to investigate the link between soil properties and compressive strength and linear shrinkage of earth mortars. A relationship between the compressive strength to CEC ratio and dry density was found, highlighting the decisive role of clay activity as expressed by CEC, in earthen materials properties. According to linear regression and dominance analysis, the strongest correlation was exhibited by SSA followed by CEC, demonstrating that compressive strength is largely dependent on these two properties. Less strong correlation was found for clay fraction content, while poorly ordered/amorphous iron oxides were found to correlate with strength and shrinkage, but their contribution requires further research. Regarding the mineralogical properties, it was found that the mortars that achieved the highest strengths contained poorly crystalline smectite clays. Finally, even significant differences in soil chemical composition did not necessarily lead to different mortar properties.
Genome-Wide CRISPR Screen Identifies Phospholipid Scramblase 3 as the Biological Target of Mitoprotective Drug SS-31
Authors: Silvaroli Josie A. , Bisunke Bijay , Kim Ji Young , Stayton Amanda , Jayne Laura A. , Martinez Shirely A. , Nguyen Christopher , Patel Prisha S. , Vanichapol Thitinee , Verma Vivek , Akhter Juheb , Bolisetty Subhashini , Madhavan Sethu M. , Kuscu Cem , Coss Christopher C. , Zepeda-Orozco Diana , Parikh Samir V. , Satoskar Anjali A. , Davidson Alan J. , Eason James D. , Szeto Hazel H. , Pabla Navjot S. , Bajwa Amandeep
Published: March 2024

Key Points

Szeto–Schiller-31–mediated mitoprotection is phospholipid scramblase 3–dependent.

Phospholipid scramblase 3 is required for recovery after AKI.

Background

The synthetic tetrapeptide Szeto–Schiller (SS)-31 shows promise in alleviating mitochondrial dysfunction associated with common diseases. However, the precise pharmacological basis of its mitoprotective effects remains unknown.

Methods

To uncover the biological targets of SS-31, we performed a genome-scale clustered regularly interspaced short palindromic repeats screen in human kidney-2, a cell culture model where SS-31 mitigates cisplatin-associated cell death and mitochondrial dysfunction. The identified hit candidate gene was functionally validated using knockout cell lines, small interfering RNA-mediated downregulation, and tubular epithelial–specific conditional knockout mice. Biochemical interaction studies were also performed to examine the interaction of SS-31 with the identified target protein.

Results

Our primary screen and validation studies in hexokinase 2 and primary murine tubular epithelial cells showed that phospholipid scramblase 3 (PLSCR3), an understudied inner mitochondrial membrane protein, was essential for the protective effects of SS-31. For in vivo validation, we generated tubular epithelial–specific knockout mice and found that Plscr3 gene ablation did not influence kidney function under normal conditions or affect the severity of cisplatin and rhabdomyolysis-associated AKI. However, Plscr3 gene deletion completely abrogated the protective effects of SS-31 during cisplatin and rhabdomyolysis-associated AKI. Biochemical studies showed that SS-31 directly binds to a previously uncharacterized N-terminal domain and stimulates PLSCR3 scramblase activity. Finally, PLSCR3 protein expression was found to be increased in the kidneys of patients with AKI.

Conclusions

PLSCR3 was identified as the essential biological target that facilitated the mitoprotective effects of SS-31 in vitro and in vivo.
Introducción
Authors: Österberg Rakel , El-Madkouri Maataoui Mohamed
Published: March 2024

Léxico y semántica (Lexicon and semantics) offers ten chapters that explore the lexicon and its semantic structures from varied perspectives, all profoundly characterized by multidisciplinarity, transversality combined with a holistic research focus, such that the themes of the lexicon and semantics have been approached from a focus which begins with etymology and philology, passes through morphology and syntax in relation to the generation of meaning, and touches on computational linguistics and translation studies. The languages of study are not limited to the more common European varieties, to those related through evolution or via geographical proximity, but we further offer a de-centering through the representation of Swedish, Japanese and Arabic.
Las series etimológicas en la investigación sobre el cambio léxico: a propósito de los verbos españoles derivados del latín mitto ’enviar’
Authors: González Pérez Rosario
Published: March 2024

The aim of this paper is to sound out the tension between innovation and tradition in lexical-semantic changes, in line with recent developments in the study of language change. We start from the hypothesis that in the conceptual configuration of the lexicon, the procedure for receiving the constituent lexical segments (inherited, multiplied and acquired lexicon) may be relevant; we must also take into account therefore the opposition between inheritance and innovation within the field of diachronic semantics. To test our hypothesis, we will carry out a diachronic semantic analysis of an etymological series, that of the heirs of the Latin verb mitto 'send', whose formal inheritance is visible in admitir, dimitir, emitir, omitir, permitir, remitir, transmitir o manumitir (admit, dismiss, issue, omit, allow, send, transmit or manumit), taking into account learned words in contrast to romance evolution (suppletian), meter (put / insert) and its possible derivatives: acometer, cometer, comprometer, entremeter, entrometer, prometer, remeter, someter (undertake, commit, compromise, interfere, promise, put back, submit), many of which had already been formed in Latin. In this research we try to verify if the etymological opacity, as compared to Latin, causes the speakers not to be aware of the original semantic relationship between the lexemes. We also try to determine if other elements come into play in the relationship between inheritance and innovation.
El léxico del Romancero Nuevo
Authors: Botta Patrizia , Marini Massimo
Published: March 2024

The paper presents data collected by the ongoing Glossary of the Romancero general of 1600, focusing on the Baroque Romancero nuevo, written by a known or identifiable author. Thus, the Glossary contains the first 450 texts drawn from a total 803 texts and has been composed by a team of 11 graduates from the University of Rome “La Sapienza”, coordinated by Patrizia Botta. A part of the Glossary has already been published and is available on the website Glossari di ispanistica (http://digilab2.let.uniroma1.it/glosarios); articles and reports on the first results gained were also published. The paper draws attention to the many cases of unica, that is, those words that have only one mention in the Glossary. The large number of these unica elevate the lexical variety of this corpus. Special attention is paid to the specific terms of the Romancero morisco, which presents a peculiar lexicon of Arabic origin, and related onomastics.
Dispositional middle constructions with accusative objects in Slovenian
Authors: Lenardič Jakob
Published: March 2024

This paper provides a study of an impersonal type of dispositional middle construction that appears in Slovenian. This impersonal construction atypically contains an undemoted thematic external argument in syntax, but nevertheless ascribes a disposition to the internal one in semantics, which goes against previous assumptions about the way in which syntax and semantics interact in middles. On the basis of this Slovenian construction, the paper develops a new syntactic and semantic analysis of the modal phrase whose head contributes the dispositional interpretation and assigns it to the internal argument. The paper shows how such an analysis accounts for both non-canonical Slovenian middles with syntactically realised external arguments as well as the more prototypical middles without external arguments both in Slovenian and English. Finally, the paper proposes why the external argument in the Slovenian impersonal middle is – exceptionally – not an intervener for the dispositional assignment.
Effect of Olive Oil Hydrogel as a Fat Replacer in Beef Meatballs
Authors: Palamutoğlu Recep , Kasnak Cemal , Özen Ünaldı Buket , Duman Sabire , Türk Baydır Ayşegül
Published: March 2024

Research background. Meat and meat products are essential sources of dietary saturated fatty acids. However, excessive consumption of meat and meat products may be harmful to human health. The study evaluates the effect of fat replacement with hydrogels (olive oil in water emulsions gelled by gelatine) in meatballs.
Experimental approach. The effect of replacing fat with different ratios of hydrogel (control, 25 (F25), 50 (F50), 75 (F75) and 100 % (F100)) on the chemical (fatty acids and thiobarbituric acid reactive substances (TBARS)) and physical (cooking loss, diameter reduction, fat retention, water retention, colour and texture analysis) characteristics of the meatballs were analyzed.
Results and conclusions. The fat content of raw meatball samples was reduced from (31.2±2.2) to (10.5±0.4) % in the sample with the highest fat substitution (F100). The energy levels of the F100 samples were almost 56 % lower than of the control group. Monounsaturated fatty acids (MUFAs) represented the dominant group in all substitution rates of the meatballs, followed by saturated fatty acids (SFAs) and finally polyunsaturated fatty acids (PUFAs). Among the raw meatball samples, the highest oxidation occurred in the F50 and F100 groups. However, it was determined that the difference between F25 and F75 and the difference between control and F75 were not statistically significant (p>0.05). When the cooked samples were compared, the highest thiobarbituric acid (TBA) value was found in the F50 sample, followed by the F100 and F75 samples. The difference between the mean values of springiness and cohesiveness of the samples was not significant (p>0.05). The hardness value of samples decreased significantly (p<0.001) with >75 % fat replacement.
Novelty and scientific contribution. It can be concluded that the oil replacement rate that may satisfy consumer demand without impairing the product technological and chemical quality should be <75 %. As the fat replacement ratio increases, the SFA content of cooked meatballs decreases, while the MUFA and PUFA contents increase. Considering the positive effects of reducing the intake of SFAs and increasing the intake of unsaturated fatty acids on non-communicable diseases such as cardiovascular diseases, fat replacement in meatballs is important for future developments.
Predicting the strength, density, and porosity of rocks from roll crusher tests
Authors: Kahraman S. , Ince I. , Rostami M. , Dibavar B.
Published: March 2024

The density, porosity, and strength of rocks are fundamental in the design of geo-engineering projects. Determining these properties requires the preparation of smooth core samples, which is usually impossible for soft rocks. Besides, only fragmented samples may be available in some projects. A method for predicting rock properties from rock particles such as drilling debris would therefore be useful. This study was undertaken to develop prediction equations for compressive strength (UCS), tensile strength (BTS), density, and porosity values from the crushability index (CI) obtained from rock fragments. The results showed that UCS, BTS, density, and porosity were strongly correlated with the CI. The physical characteristics and strength of rocks may be predicted with the help of the derived equations. The CI test is a valuable tool for estimating rock properties in drilling projects and in situations where core specimens are not available.
Satisfacción con la compra de ropa en línea: análisis de sus antecedentes
Authors: Cavazos-Arroyo Judith , Máynez-Guaderrama Aurora , Vargas Salgado María Marisela
Published: March 2024

Cuando las empresas comprenden las variables que impulsan la satisfacción de los clientes, pueden establecer mejores puntos de referenciay perfeccionar sus estrategias. En la actualidad, existe un crecimiento exponencial de las compras de ropa de moda a través de plataformasdigitales. Esta investigación evalúa si la orientación a la moda rápida y a la moda lenta, la conciencia ambiental y las experiencias del producto,emocional y con el sitio web inciden sobre la satisfacción con la compra en línea. Además, se analiza la importancia y el rendimiento de las experienciassobre la satisfacción. Las técnicas estadísticas utilizadas son un modelo de ecuaciones estructurales basados en mínimos cuadrados parcialesy una matriz de importancia-desempeño. El diseño de investigación fue cuantitativo, explicativo y transversal, desarrollado en la frontera nortede México y aplicado a 539 compradores de ropa en plataformas web o aplicaciones digitales. Los resultados evidencian que solo la orientación a la moda lenta influye sobre la conciencia ambiental, a diferencia de la orientación a la moda rápida que no tiene efecto en ella, la concienciaambiental tiene un impacto positivo sobre los tres tipos de experiencia y éstos inciden favorablemente sobre la satisfacción con la compra de ropa en línea. La matriz importancia-desempeño evidenció que la experiencia con el sitio web/app es el factor más relevante para la satisfacción en línea. En conclusión, la satisfacción con la compra en línea depende en gran medida de la experiencia con el sitio web.
Navigating the Digital Landscape: Factors Shaping Entrepreneurial Dynamics in Saudi Arabia
Authors: Al-Ghazali Basheer
Published: March 2024

This paper provides a comprehensive analysis of the factors impacting entrepreneurial intentions, behaviors, innovations, and senses of self-efficacy in the digital entrepreneurial ecosystem in the Kingdom of Saudi Arabia. Through illuminating the roles of ecosystem, entrepreneurial intention, innovation, and education, the study aspires to provide insights into the distinctive dynamics of digital entrepreneurship in this geographical setting. The study makes use of both qualitative in-depth interviews with subject matter experts and quantitative statistical analysis of survey responses. The Saudi digital entrepreneur ecosystem is explored qualitatively through 15 in-depth interviews with industry experts, and quantitatively with 248 survey responses that allow for hypothesis testing using structural equation modeling. The quantitative data in this study was analyzed using PLS-SEM. The results emphasize the mediating roles of entrepreneurial ambition and innovation, highlighting the key significance of the digital entrepreneurial ecosystem in driving entrepreneur behavior. Entrepreneurial education emerges as a powerful element, acting as both a moderator in shaping entrepreneurial success. The research provides useful information about the unique characteristics of digital entrepreneurship in Saudi Arabia.