bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplicación interactiva para la estimulación fonética en niños escolares con trastornos fonológicos
Authors: Ramirez Lozano Maria Tatiana , Puello Sepúlveda Saray Julia , Payares Matute Elda Rosana
Published: January 2023

El presente artículo surge del estudio  que se ha realizado alrededor del tema de los trastornos fonológicos en los niños de  4 a   7 años de edad,  que  presentan un habla  ininteligible y evidencian  trastornos fonológicos, siendo esto motivo de consulta frecuente para el fonoaudiólogo, dado que las afectaciones mencionadas, limitan la interacción comunicativa en el aula, en el hogar y demás contextos; de esta forma, se  requiere que el niño logre la emisión de  puntos y modos de articulación, sin embargo, no hay un catálogo amplio de  materiales integrales e  interactivos que permitan de forma lúdica, facilitar la emisión fonética o reestructurar el modelo inadecuado de pronunciación, reprogramándolo adecuadamente la pronunciación en los niños.

Es por eso, que se presenta una propuesta de aplicación tecnológica como  estrategia de estimulación fonética, diseñadas  mediante en un  software interactivo, denominado VEP 1 (Veo, escucho y pronuncio: Jugando con los sonidos),  que dentro del aula permitiría  la estimulación audiovisual del  repertorio fonético básico de los niños, con  la visualización y escucha de los modos articulatorios oclusivos, fricativos, laterales, nasales y vibrantes, asociados a imágenes explicativas, complementadas con la identificación de la sonoridad en cada uno.

Es importarte mencionar, que este artículo se deriva del proyecto de investigación titulado: programa de estimulación de rasgos fonéticos en niños de 4 a 7 años, realizado por un equipo de investigación conformado por tres fonoaudiólogas y un ingeniero de software, quienes son docentes de Instituciones colombianas de Educación Superior en Barranquilla, Bogotá y Medellín.
Estrategias de intervención fonoaudiológicas empleadas para el manejo de la disartria: Una revisión narrativa
Authors: Donneys Valencia Ximena , Córdoba Cuarán Jennifer Andrea , Matos Rojas Daniela , Sánchez Girón Leidy Katherine
Published: January 2023

La presente investigación es una monografía de tipo revisión narrativa, que surgió a partir de la necesidad que se presenta en el área de rehabilitación humana de realizar intervenciones terapéuticas fundamentadas en evidencia científica, en la que se busca identificar las estrategias actuales que se emplean en el manejo de la disartria en diferentes contextos territoriales.

El objetivo general de esta revisión, fue identificar las estrategias de intervención que utilizan los fonoaudiólogos y fonoaudiólogas para el manejo de la disartria, mediante una revisión narrativa basada en evidencia científica, en las bases de datos PubMed, Scopus, Springer Link y Science Direct, en el período de 2011 a 2021, proporcionando así una línea de base para estudiantes y profesionales en fonoaudiología como herramienta de intervención para la práctica clínica.

En cuanto a la metodología, se realizó una búsqueda en las bases de datos mencionadas anteriormente. Se seleccionaron 80 artículos potenciales para la investigación, que, tras la evaluación del contenido y los criterios de elegibilidad, se acotaron a 16, realizando posteriormente una sistematización de los hallazgos.

Los resultados se dieron con base en las variables sociodemográficas, metodológicas y temáticas de la investigación, permitiendo identificar y describir 12 estrategias implementadas desde la fonoaudiología para la intervención de la disartria.

En conclusión, se logró rescatar 16 estudios que sustentaban estar basados en evidencia científica, en los cuales determinaban que las estrategias estaban puestas en intervenciones con pacientes disártricos y que demostraron mejoría, por lo cual pueden ser implementadas en la práctica clínica profesional.
Estimulación del lenguaje infantil mediada por aplicaciones digitales dirigidas a padres
Authors: Morales-Rojas Daniela Alexandra , Murcia Gutiérrez Diego Ferney , Mateus Moreno Angelica , Moreno Pastas Leydy Sofia
Published: January 2023

Los programas de estimulación infantil han resultado fundamentales para favorecer diferentes habilidades durante el desarrollo de los niños y niñas en el mundo. Actualmente, existe poco conocimiento sobre programas de estimulación de lenguaje dirigidos a los padres, quienes son los que más tiempo comparten con los niños y podrían favorecer desde su cotidianidad las habilidades de lenguaje. Objetivo: identificar los hallazgos más recientes de la literatura sobre aplicaciones de estimulación de lenguaje dirigidas a padres de niños con desarrollo típico y con trastornos del lenguaje y la comunicación. Método: Se realizó una búsqueda documental de investigaciones teniendo en cuenta los criterios de selección planteados por los investigadores a través de diferentes bases de datos y se incluyeron dentro de la revisión doce investigaciones para realizar análisis a profundidad.  Resultados y conclusiones: Todas las aplicaciones revisadas buscan enseñar habilidades y estrategias de estimulación a los padres, que faciliten un ambiente favorecedor para el desarrollo del lenguaje de sus hijos; empleando estrategias de estimulación similares y la totalidad de las aplicaciones fueron reportadas por los autores como eficientes, además de ampliamente valoradas por los participantes de los estudios. Sin embargo, se encontró que existe un bajo número de investigaciones publicadas, por lo tanto, los hallazgos de esta revisión reflejan la necesidad de proponer y diseñar herramientas tecnológicas que se orienten al entrenamiento de padres hispanohablantes, en un intento por mejorar el acompañamiento a los procesos de desarrollo del lenguaje infantil.
Conocimiento y percepción del rol fonoaudiológico en la atención de neonatos prematuros
Authors: Vargas Garcia Miguel Antonio , Mazo Velasco María Isabel
Published: January 2023

La labor del fonoaudiólogo en la Unidad de Cuidado Critico Neonatal fundamenta el cuidado y mantenimiento de la vida consolidando métodos de alimentación seguros y eficaces en los pacientes. La triada succión-deglución-respiración es un recurso fisiológico alimentario que al alterarse desencadena factores de riesgo en la salud neonatal. Para abordar los riesgos producidos por la incoordinación succión-deglución-respiración, este trabajo busca describir el conocimiento y la percepción del rol del fonoaudiólogo en la atención de neonatos prematuros en la Clínica Universitaria Bolivariana durante el 2021-2022. La metodología fundamentó un estudio descriptivo transversal bajo un enfoque mixto de análisis de instrumentos. Contó con la ejecución de una encuesta tipo Likert de auto diligenciamiento, entrevistas semiestructuradas y el desarrollo de dos grupos focales. Para referencia del estudio participan 6 profesiones vinculadas a las unidades de cuidados neonatales con un total de 33 participantes con una media de 9 años de experiencia profesional. El 93,9% reconoce el término disfagia; este mismo porcentaje reconoce el concepto de succión nutritiva y no nutritiva. Quienes dicen conocer el termino disfagia, están muy de acuerdo con que sea tratada en un 97%. Sin embargo, no reconocen al fonoaudiólogo como el profesional que define criterios de alimentación en los nacidos prematuros. Las conclusiones, sugieren la visualización activa del fonoaudiólogo dentro de equipos en unidades de cuidado neonatal, bajo la proyección de consolidar la rehabilitación deglutoria de los nacidos pretérminos.
"Si usted es varón vaya juegue futbol, vaya revuélquese o vaya pelee": Narrativas de roles de género en adolescentes transgénero y cisgénero de la ciudad de Medellín.
Authors: Moreno Rangel Néstor Eliécer , Velásquez Mejía Laura Sofia , Castiblanco Alfonso Nestor Camilo
Published: January 2023

Para aproximarse a la comprensión de los roles de género en un grupo de adolescentes transgénero y cisgénero de 11 a 18 años de edad en la ciudad de Medellín, entendiendo que, a través del proceso socializante, se mantienen modelos estrictos de adecuación y deseabilidad del ser mujer u hombre, donde las expresiones identitarias trans, representan la contradicción de las expectativas sociales respecto a la triada sexo/género/política, fueron desarrolladas ocho entrevistas semiestructuradas. Dichas entrevistas, conducidas desde una perspectiva de narratividad, fueron co-construidas recabando en nociones únicas y particulares de las y los participantes, pero también comprendiendo algunos elementos en las que aquellos confluyen, se intersectan y comparten las reflexiones. Se encontró que tanto las y los adolescentes trans cuanto los cis cuestionan fuertemente algunas de esas reglas establecidas, poniendo en evidencia las desventajas y privilegios otorgadas a unas y a otros. La genitalidad y reproducción humana como lógica funcionalista que sobrecarga en la condición biológica la identidad de género, son puestos en entredicho por las y los participantes trans, quiénes dan mayor importancia a sus propias identificaciones, necesidades afectivas, emocionales y sociales en la construcción de la identidad de género. Todas las participaciones son coincidentes en poner de manifiesto cambios importantes en la manera en que son construidos y exigidos unos papeles sociales derivados del género, visando su transformación en favor de una mirada menos sexista en el reconocimiento y puesta en juego de los roles de género esperados y posibles para todas las personas.
Salud familiar y desarrollo de la autodeterminación en adolescentes con discapacidad físico-motora
Authors: Rodríguez-Abreu Yanetsy , Turtós Carbonell Larissa Beatriz , Cañamero Dinza María Trinidad
Published: January 2023

Introducción. El desarrollo de la autodeterminación es fundamental para que las personas con discapacidad físico-motora afronten sus desventajas personales y sociales y se adapten óptimamente al entorno. Objetivos. Caracterizar el desarrollo de la autodeterminación y la salud familiar de adolescentes con discapacidad físico-motora, e identificar relaciones de asociación entre salud familiar y autodeterminación. Metodología. Se realizó un estudio cuantitativo transversal, de tipo descriptivo-correlacional. Participaron 23 adolescentes con discapacidad físico-motora y sus familias. Los datos se obtuvieron mediante instrumentos de exploración de autodeterminación y salud familiar. El procesamiento estadístico se realizó con Distribuciones de Frecuencias y Regresión Ordinal Múltiple. Resultados. Se obtuvo bajo nivel de salud familiar y bajo nivel de desarrollo de la autodeterminación en la mayoría de los casos. Los indicadores de salud familiar asociados al desarrollo de la autodeterminación fueron, ambiente familiar, roles, capacidad comunicativa, ética relacional de la familia y capacidad de adaptabilidad familiar.
Un día en la vida de niños y niñas del Suroccidente Colombiano con experiencias de violencia sociopolítica
Authors: Ordoñez Morales Oscar - , Claro La Rotta Silvana Del Pilar
Published: January 2023

La investigación desarrollista sobre la violencia socio-política se ha centrado principalmente en explicar sus efectos psicológicos a mediano y largo plazo en la niñez y ha generalizado a partir de grandes muestras. Pocos estudios se han centrado en explorar momento a momento las experiencias de la vida cotidiana de niños y niñas que sufrieron episodios de ese tipo de violencia. En esta investigación se usó un diseño basado en la observación de un día en la vida de dos niñas y dos niños del Suroccidente Colombiano para describir el contexto en que se desarrollan, cómo se ven a sí mismos y cómo resignifican experiencias de violencia política que vivieron en su primera infancia. Se usaron relatos autobiográficos, entrevistas y un análisis de temas emergentes. Se identificaron identidades y experiencias estrechamente ligadas a la construcción de relaciones basadas en el respeto a los demás, la valoración positiva de sí mismos, el reconocimiento de la familia como organizadora de sus experiencias, la construcción de saberes para desarrollar habilidades y la resignificación de las experiencias dolorosas. La discusión se centró en las implicaciones de adoptar una concepción del proceso de desarrollo en términos de trayectorias de desarrollo no siempre previsibles, ni orientadas a un estado final; así como el papel que tiene el método seleccionado en esa indagación. Se concluye que las experiencias actuales no necesariamente se derivan de trayectorias lineales, pues son afectadas por factores situacionales inherentes a la ecología social en las que viven las personas.
Comunicación no verbal de emociones: variables sociodemográficas y ventaja endogrupal
Authors: Bravo Verdugo Edwin Ricardo , Moreno Candil David
Published: January 2023

En el campo de la comunicación no verbal de las emociones aún existe un debate en torno a la universalidad de las expresiones de emoción y el efecto que tiene la cultura en ellas. Actualmente existen dos teorías que tratan de explicar este fenómeno, la teoría neurocultural y la teoría de los dialectos. Ambas se enfocan en explicar la comunicación no verbal de emociones, pero la primera se centra en los aspectos universales, mientras que la segunda lo hace en la cultura. El objetivo del presente estudio fue indagar la ventaja endogrupal al interior de una cultura. Se diseñó un cuasiexperimento en el que se solicitó a 107 participantes que indicaran la emoción expresada en 42 estímulos en tres formatos de presentación distintos.  Los resultados indican la existencia de dicha ventaja en las mujeres y jóvenes. Los presentes resultados ilustran los efectos de la cultura en este fenómeno.
Additive manufacturing technologies in the oral implant clinic: A review of current applications and progress
Authors: Huang Shitou , Wei Hongbo , Li Dehua
Published: January 2023

Additive manufacturing (AM) technologies can enable the direct fabrication of customized physical objects with complex shapes, based on computer-aided design models. This technology is changing the digital manufacturing industry and has become a subject of considerable interest in digital implant dentistry. Personalized dentistry implant treatments for individual patients can be achieved through Additive manufacturing. Herein, we review the applications of Additive manufacturing technologies in oral implantology, including implant surgery, and implant and restoration products, such as surgical guides for implantation, custom titanium meshes for bone augmentation, personalized or non-personalized dental implants, custom trays, implant casts, and implant-support frameworks, among others. In addition, this review also focuses on Additive manufacturing technologies commonly used in oral implantology. Stereolithography, digital light processing, and fused deposition modeling are often used to construct surgical guides and implant casts, whereas direct metal laser sintering, selective laser melting, and electron beam melting can be applied to fabricate dental implants, personalized titanium meshes, and denture frameworks. Moreover, it is sometimes required to combine Additive manufacturing technology with milling and other cutting and finishing techniques to ensure that the product is suitable for its final application.
Construction of a ternary component chip with enhanced desorption efficiency for laser desorption/ionization mass spectrometry based metabolic fingerprinting
Authors: Ding Yajie , Pei Congcong , Li Kai , Shu Weikang , Hu Wenli , Li Rongxin , Zeng Yu , Wan Jingjing
Published: January 2023

Introduction:In vitro metabolic fingerprinting encodes diverse diseases for clinical practice, while tedious sample pretreatment in bio-samples has largely hindered its universal application. Designed materials are highly demanded to construct diagnostic tools for high-throughput metabolic information extraction.

Results: Herein, a ternary component chip composed of mesoporous silica substrate, plasmonic matrix, and perfluoroalkyl initiator is constructed for direct metabolic fingerprinting of biofluids by laser desorption/ionization mass spectrometry.

Method: The performance of the designed chip is optimized in terms of silica pore size, gold sputtering time, and initiator loading parameter. The optimized chip can be coupled with microarrays to realize fast, high-throughput (∼second/sample), and microscaled (∼1 μL) sample analysis in human urine without any enrichment or purification. On-chip urine fingerprints further allow for differentiation between kidney stone patients and healthy controls.

Discussion: Given the fast, high throughput, and easy operation, our approach brings a new dimension to designing nano-material-based chips for high-performance metabolic analysis and large-scale diagnostic use.
Recent advances of antioxidant low-dimensional carbon materials for biomedical applications
Authors: Tang Nan , Ding Zhen , Zhang Jin , Cai Yanting , Bao Xingfu
Published: January 2023

As the primary cause of many tissue damage and diseases, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well known to be extremely harmful to a variety of biological components in cells including lipids, proteins and DNA. Numerous antioxidative nanomaterials have been artificially designed and rationally synthesized to protect cells from the oxidative damage caused by reactive oxygen species/reactive nitrogen species. Recent studies demonstrate that low dimensional carbon antioxidative nanomaterials have received a lot of attention owing to their tiny nanoscales and unique physicochemical property. As a result, a brief overview of recent advancements in antioxidant low-dimensional carbon materials is provided. Typically, carbon nanomaterials are classified according to their nanostructure dimensions, which are zero-dimension, one-dimension, and two-dimension. Last but not least, the challenges and perspectives of these high-performance low-dimensional materials in biomedical fields and further clinical usages are discussed as well.
A review of durability improvement in concrete due to bacterial inclusions
Authors: Bandlamudi Radha Kiranmaye , Kar Arkamitra , Ray Dutta Jayati
Published: January 2023

Since the invention of industrially produced Portland cement in the nineteenth century, concrete has been the world’s most frequently used construction material. Because of the significant CO2 emissions produced during cement manufacture and concrete maintenance and repair costs, sustainably improving concrete durability has become a topic of concern. Bacterial self-healing is a unique method that uses CaCO3 precipitation to repair cracks in concrete, thereby improving the structure’s durability. This review highlights the effect of bacterial treatment on concrete durability. The permeation properties, water absorption, and mechanical properties are assessed. Emphasis is laid on the selection of bacteria and bacteria nutrients. The paper overviews the morphological analysis of CaCO3 precipitation by bacterial concrete. Despite the benefits of bacterial technology in concrete, numerous critical concerns remain unresolved. Further investigation on nutrients is required to develop a multi-nutrient system that will improve the efficiency of bacterial precipitation since a good combination of low-cost nutrients would reduce the total cost of bacterial concrete.
The aqueous supramolecular chemistry of crown ethers
Authors: Qi Zhenhui , Qin Yao , Wang Jijun , Zhao Maojin , Yu Zhuo , Xu Qiangqiang , Nie Hongqi , Yan Qilong , Ge Yan
Published: January 2023

This mini-review summarizes the seminal exploration of aqueous supramolecular chemistry of crown ether macrocycles. In history, most research of crown ethers were focusing on their supramolecular chemistry in organic phase or in gas phase. In sharp contrast, the recent research evidently reveal that crown ethers are very suitable for studying abroad range of the properties and applications of water interactions, from: high water-solubility, control of Hofmeister series, “structural water”, and supramolecular adhesives. Key studies revealing more details about the properties of water and aqueous solutions are highlighted.
Information consistency as response to pre-launch advertising communications: The case of YouTube trailers
Authors: Kampani Julia , Nicolaides Christos
Published: January 2023

Introduction

Pre-launch advertising communications are critical for the early adoption of experiential products. Often, companies release a variety of advertising messages for the same product, which results in a lack of information consistency. Research on the effect of advertising communications with different message content is scarce. Further, most studies on information consistency rely on experimental methods, leaving the actual effect of consumer response on product adoption unknown.

Methods

Treating online comments to movie trailers as consumer response to advertising communication, we propose a natural language processing methodology to measure information consistency. We validate our measurement through an online experiment and test it on 1.3 million YouTube comments.

Results

Our empirical results provide evidence that information consistency driven by trailer-viewing is a key driver of opening box office success.

Discussion

Insights deriving from this study are important to marketing communications research, especially in contexts where early product adoption is critical.
In silico identification of potential inhibitors of acyl carrier protein reductase and acetyl CoA carboxylase of Plasmodium falciparum in antimalarial therapy
Authors: Salifu Elliasu Y. , Abugri James , Rashid Issahaku A. , Osei Festus , Ayariga Joseph Atia
Published: January 2023

Malaria caused by Plasmodium falciparum, remains one of the most fatal parasitic diseases that has affected nearly a third of the world’s population. The major impediment to the treatment of malaria is the emergence of resistance of the P. falciparum parasite to current anti-malaria therapeutics such as Artemisinin (ART)-based combination therapy (ACT). This has resulted in countless efforts to develop novel therapeutics that will counter this resistance with the aim to control and eradicate the disease. The application of in silico modelling techniques has gained a lot of recognition in antimalarial research in recent times through the identification of biological components of the parasite for rational drug design. In this study we employed various in silico techniques such as the Virtual screening, molecular docking and molecular dynamic simulations to identify potential new inhibitors of biotin acetyl-coenzyme A (CoA) carboxylase and enoyl-acyl carrier reductase, two enzyme targets that play a crucial role in fatty acid synthesis in the Plasmodium parasite. Initially, nine hit compounds were identified for each of the two enzymes from the ZINCPharmer database. Subsequently, all hit compounds bind favourably to the active sites of the two enzymes as well as show excellent pharmacokinetic properties. Three 3) of the hits for the biotin acetyl-coenzyme A (CoA) carboxylase and six 6) of the enoyl-acyl carrier reductase showed good toxicity properties. The compounds were further evaluated based on the Molecular Dynamics simulation that confirmed the binding stability of the compounds to the targeted proteins. Overall, the lead compounds ZINC38980461, ZINC05378039, and ZINC15772056, were identified for acetyl-coenzyme A (CoA) carboxylase whiles ZINC94085628, ZINC93656835, ZINC94080670, ZINC1774609, ZINC94821232 and ZINC94919772 were identified as lead compounds for enoyl-acyl carrier reductase. The identified compounds can be developed as a treatment option for the malaria disease although, experimental validation is suggested for further evaluation of the work.
Modeling and analysis of hydraulic fracture complexity index in sandy conglomerate reservoirs based on genetic expression programming—A case study in Xinjiang Oilfield
Authors: Zhang Long , Wang Zhenhua , Xu Rui , Cheng Hao , Ren Lan , Lin Ran
Published: January 2023

The stimulation effect of oil wells is seriously affected by the complexity of hydraulic fractures, and the analysis of the factors that control the fracture complexity index has become the key to fracturing design in sandy conglomerate reservoirs. Based on the intrinsic relationship between geological engineering parameters and the fractures complexity index, a Genetic Expression Programming (GEP) method, which has broad advantages in solving multi-factor nonlinear fitting and black-box prediction problems, is proposed to analyze the hydraulic fracture complexity index. Combined with the geoengineering factors that affect the hydraulic fractures propagation, a comprehensive index calculation method is established to analyze the relative importance of these features and 18 reconstructed features were obtained by collecting the geoengineering parameter data of 118 fracturing sections in 8 fracturing wells in Jinlong oilfield. The principal component analysis was performed to eliminate the interaction between the features, and then a GEP-based fractures complexity index calculation model was developed. The partial dependence plot is used to analyze the influence of the main control feature (variable) on the hydraulic fracture complexity index. It showed that GEP model can achieve satisfactory performance (Training set: R = 0.861; Test set: R = 0.817) by statistical parameters. The results showed that the model can calculate the hydraulic fracture complexity index quickly and precisely. The influence of geological engineering control factors can be obtained. It proved that the GEP method can effectively analyze and evaluate the complexity in sandy conglomerate reservoirs.
Diagenesis of the first member of Canglangpu Formation of the Cambrian Series 2 in northern part of the central Sichuan Basin and its influence on porosity
Authors: Zou Bing , Qu Haizhou , Zhao Rongrong , Zhang Lianjin , Zhang Yu , Ma Zike , Zhang Xingyu , Huang Qinyang , Mo Qianwen , An Hongyi , Pei Yu
Published: January 2023

In this paper, taking the first Member of the Canglangpu Formation of the Cambrian Series 2 in the northern central Sichuan Basin as an example, the diagenesis and its influence on porosity are systemically studied based on the observations and identifications of cores, casts and cathodoluminescence thin sections. The results show that the rock types of the first member of Canglangpu Formation are various, including mixed rocks, carbonate rocks and clastic rocks. The specific lithology is dominated by sand-bearing oolitic dolomite, sandy oolitic dolomite, sparry oolotic dolomite and fine-grained detrital sandstone. At the same time, the Cang 1 Member has experienced five types of diagenetic environments, including seawater, meteoric water, evaporative seawater, shallow burial, and medium-deep burial diagenetic environments. Moreover, the main diagenetic processes under different diagenetic environments include cementation, dissolution, compaction, chemical compaction, dolomitization and structural fractures. According to the analysis, fabric-selective dissolution in meteoric water diagenetic environment, dolomitization in evaporative seawater environment, and non-fabric-selective dissolution, dolomitization and structural fractures in buried diagenetic environment are beneficial to the development of pores. However, cementation, compaction and chemical compaction in medium and deep burial environments, are unfavorable for the development of pores.
Influence of the bedding plane on the propagation of multiple hydraulic fractures
Authors: Ma Yulin , Wang Ding , Zheng Yongxiang
Published: January 2023

The presence of bedding planes (BPs) in unconventional shale reservoirs is common and widespread. BPs always affect fracture propagation. The objective of this study was to investigate the impacts of BPs on multiple hydraulic fracturing. The BPs were assumed to be perpendicular to the direction of the fractures. Based on the block distinct element method, we established a numerical model to simulate multiple fracture propagation in reservoirs with BPs. The model considered the fluid partitioning of multiple fractures and the fracture interaction by stress shadow. The numerical simulations clearly showed that the BPs reduced the non-uniform growth of multiple fractures. The results indicated that when hydraulic fractures met BPs, the BPs likely prevented the hydraulic fractures from passing through the formation with a smaller stress contrast. When hydraulic fracturing in a formation containing BPs, the key problem is how to reduce the obstructive effects of the BPs to increase the length of the main fractures.
Land‒atmosphere coupling effects of soil temperature and moisture on extreme precipitation in the arid regions of Northwest China
Authors: Wu Shuting , Wei Zhigang , Li Xianru , Ma Li
Published: January 2023

With global warming and more frequent extreme precipitation events in recent years, the phenomenon of warming and humidification in the arid regions of Northwest China (ANWC) has attracted increasing attention. We assessed the coupling effects of soil temperature and moisture on extreme precipitation in the ANWC by using daily precipitation data from CN05.1 and monthly data on soil temperature, soil moisture, and energy from ERA5-land, 1961–2018. After logical partitioning by K-means clustering, the primary influencing routes in each partition were investigated using two indices of extreme precipitation, indicated by precipitation on very wet days (R95P) and the number of extreme precipitation days (R10day). We found that 1) Local extreme precipitation has had a steadily growing impact on overall precipitation. In summer, this impact is primarily driven by an increase in the quantity of extreme precipitation, but in winter, it is primarily driven by an increase in the intensity of single precipitation. 2) The Tianshan Mountains (TM) and Qilian Mountains (QM) are the key locations for the coupling of soil temperature and moisture with the extreme precipitation index. Both locations exhibit a positive coupling state for soil temperature with extreme precipitation with positive coupling in the TM but negative coupling in the QM for soil moisture with extreme precipitation. 3) In the coupling of soil temperature and moisture with energy, the relevant significant regions are almost all over the ANWC throughout the year and all seasons, and the coupling high-value areas are concentrated around the basin. 4) In the TM–Hami Basin (HB)–QM, the coupling between energy and the extreme precipitation index is also stronger. The specific coupling paths have been changing with seasonal and regional changes.
Sensitivity experiments of RegCM4 using different cumulus and land surface schemes over the upper reaches of the Yangtze river
Authors: Li Bingxue , Huang Ya , Du Lijuan , Wang Dequan
Published: January 2023

For the optimal performance of climate simulation, it is critical to localize physical parameterization schemes of climate models, especially in regions with unique geographic characteristics. To study the performance of different physical parameterization schemes for climate simulation in the upper reaches of the Yangtze River Basin (UYRB), we conducted short-term simulations with a resolution of 50 km from 1990 to 1993 using RegCM4 driven by ERA-Interim. Simulations with 72 different scheme combinations were conducted and analyzed to identify the optimal cumulus convection schemes (CSs) and the land surface process schemes in the RegCM4 model. Using the multi-standard scoring method, we evaluated the model performance of precipitation and temperature over the UYRB with different physical parameterization schemes. The results show that precipitation is more sensitive to the CSs than the LSPs. Among the selected CSs, the Kain-Fritsch scheme can better reproduce precipitation characteristics of the UYRB, with a wet bias of only 0.2 mm/day for the multi-year average precipitation. Compared to the community land model (CLM 3.5 and CLM4.5), the Biosphere-Atmosphere Transfer Scheme (BATS) performs better in reproducing temperature characteristics of the UYRB, with an average cold bias of only 0.2°C for all BATS schemes. The soil moisture, evapotranspiration and precipitation are lower and sensible heat flux is higher in CLM simulations, which can account for CLMs simulating warmer temperatures than BATS. The results provide a baseline for the localization of the RegCM4’s parameterization schemes in the UYRB and other regions of China.
Recent progress in understanding the interaction between ENSO and the East Asian winter monsoon: A review
Authors: Ma Tianjiao , Chen Wen
Published: January 2023

This paper reviews recent advances in understanding the interaction between the East Asian winter monsoon (EAWM) and El Niño-Southern Oscillation (ENSO). The achievements are summarized into two aspects: 1) the impacts of ENSO on the EAWM, and 2) effects of the EAWM on ENSO. For the first aspect, the results show that: the current climate model simulations of ENSO impacts on the EAWM have a common weaker bias than in the observations; The influence of central Pacific type ENSO on the EAWM is generally weaker than that of the eastern Pacific type ENSO; The precipitation anomalies in the tropical Indian Ocean tend to contribute to the intra-seasonal transition of ENSO teleconnection over East Asia; The ENSO-EAWM relationship is unstable and subject to non-linear modulation by the state of oceans and extratropical atmospheric phenomena, which include the Pacific Decadal Oscillation and the Arctic Oscillation. Regarding the second aspect, studies have shown that the “pure” EAWM (denoted as EAWMres), which is independent of the ENSO signal, can lead to significant variations in the tropical convection over the western Pacific, the local Hadley circulation over East Asia, and the Walker circulation over the equatorial latitudes; The CMIP6 models can preproduce the above EAWMres effects well, although with some weaker bias. The changes in tropical convection and extratropical zonal flow associated with the EAWMres tend to have a significant modulating effect on the ENSO atmospheric teleconnection over North America. A strong EAWM and a strong Australian summer monsoon coherently provide favorable conditions for the onset of El Niño.
Investigating the simultaneous fracture propagation from multiple perforation clusters in horizontal wells using 3D block discrete element method
Authors: He Rui , Yang Jian , Li Li , Yang Zhaozhong , Chen Weihua , Zeng Ji , Liao Xingchuan , Huang Liuke
Published: January 2023

Multi-cluster horizontal well fracturing is one of the key technologies to develop the unconventional reservoirs such as shales. However, the field data shows that some perforation clusters have little production contribution. In this study, a three-dimensional (3D) numerical model for simulating the multiple fracture propagation based on 3D block discrete element method was established, and this model considers the stress interference, perforation friction and fluid-mechanical coupling effect. In order to determine the most appropriate measures to improve the uniformity of multiple fracture propagation, the effect of the geologic and engineering parameters on the multiple fracture propagation in shale reservoirs is investigated. The modeling results show that the geometry of each fracture within a stage is different, and the outer fractures generally receive more fracturing fluid than the interior fractures. The vertical stress almost has no effect on the geometries of multiple fractures. However, higher horizontal stress difference, larger cluster spacing, smaller perforation number, higher injection rate, and smaller fracturing fluid viscosity are conducive to promote the uniform propagation of multiple fractures. The existence of bedding planes will increase the fluid filtration, resulting in a reduction in fracture length. The middle two fractures receive less fluid and the width of them is smaller. Through analyzing the numerical results, a large amount of fracturing fluid should be injected and the proppant with smaller size is suggested to be used to effectively prop the bedding planes. Cluster spacing and perforation number should be controlled in an appropriate range according to reservoir properties. Increasing the injection rate and reducing the viscosity of fracturing fluid are important means to improve the geometry of each fracture.
Influence of normal stress on the shear strength of the structural plane considering the size effect
Authors: Huang Yuxi , Hu Gaojian
Published: January 2023

The shear strength of a structural plane is a critical parameter in the analysis of engineering rock stability. Significant differences exist due to the various normal stresses in the structural plane. Therefore, evaluating the rock deformation to effectively determine the influence of normal stresses at different scales on the shear strength of structural planes is of great significance. This study discusses the effects of normal stress and structural plane size on shear strength through numerical simulations and regression analysis. The results showed that the shear strength of the structural plane increases linearly with increasing normal stress. The shear strength of the structural plane decreases with increasing size, and the corresponding curve is exponential. The characteristic size and shear strength increase linearly with increasing normal stress. This paper presents the concrete form of these relationships, which can be used to calculate and predict the shear strength, which has significance in guiding engineering.
A preliminary study on the mechanism of the Liangzhu culture’s migration across the Yangtze river
Authors: Xiao Jiayi , Shang Zhiyuan , Zhang Zixin , Xiao Shengjun , Jia Xin
Published: January 2023

The Liangzhu culture (5300–4200 cal BP) was the most famous Neolithic culture of who settled near the lower reaches of the Yangtze River in China. The core and initial distribution area of Liangzhu originated around Taihu Lake, located on the south bank of the Yangtze River delta. Recently, archaeological studies believe that the Jianghuai area and Huanghuai area north of the Yangtze River are also important distribution areas of Liangzhu culture. The route for Liangzhu culture migrating across the Yangtze River is inferred as follows: One would have crossed the Yangtze River from Nanjing-Zhenjiang belt and continued to migrate northward; while the other would have crossed the River near the estuary before moving north along the ancient coastline to the Jianghuai during the late period of Liangzhu, or crossed the Yangtze River from the east of the present Beijing-Hangzhou Grand Canal to Jianghuai and Huanghuai. According to the formation of the Yangtze River delta during the Holocene and the evolution of the estuarine sand bar, it is believed that there were large shoals in the Yangtze River channel in the middle-Holocene. The Liangzhu ancestors around 5000 cal BP had the ability of making canoes over 8 m. Based on the archaeological research of the Neolithic period, the evolution of the Yangtze River channel in the Holocene, the history of ancient Chinese shipbuilding, and the modern examples of crossing the Yangtze River with boat, it can be concluded that the present Changzhou–Jiangyin–Zhangjiagang line should be the main and reasonable route for the Liangzhu culture migrating across the Yangtze River.
Ethical relationality, TribalCrit, and autobiographical narrative inquiry: Imagining coming alongside Indigenous children
Authors: Cardinal Trudy , Stavrou Stavros , Murphy M. Shaun , Huber Janice
Published: January 2023

Creating this chapter brought us together as a diverse group of scholars to think deeply about a process of reflection in teacher education that centers on ethical relationality. To show our coming alongside adult learners attentive to reflection that centers ethical relationality, we inquire into both the Assessment as Pimosayta courses that Murphy, Cardinal, and Huber teach and into Stavrou's experiences teaching and enacting assessment in his practice. The body of our chapter is structured by the five design elements foregrounded by Stavrou and Murphy's recent bringing of critical race theory and anti-racist education to narrative inquiry: beginning with experience; carrying theoretical frameworks into an inquiry; negotiating theoretical frameworks with participants; using narrative threads to show the complexity of experience; ending in experience. Centering ethical relationality as we come alongside pre- and in-service teachers as they imagine coming alongside Indigenous children, youth, families, and communities lifts the long-termness of our work, including that this long-termness entails interactions and responsibilities with other humans and more-than-human beings.
Implementation of five machine learning methods to predict the 52-week blood glucose level in patients with type 2 diabetes
Authors: Fu Xiaomin , Wang Yuhan , Cates Ryan S. , Li Nan , Liu Jing , Ke Dianshan , Liu Jinghua , Liu Hongzhou , Yan Shuangtong
Published: January 2023

Objective

For the patients who are suffering from type 2 diabetes, blood glucose level could be affected by multiple factors. An accurate estimation of the trajectory of blood glucose is crucial in clinical decision making. Frequent glucose measurement serves as a good source of data to train machine learning models for prediction purposes. This study aimed at using machine learning methods to predict blood glucose for type 2 diabetic patients. We investigated various parameters influencing blood glucose, as well as determined the most effective machine learning algorithm in predicting blood glucose.

Patients and methods

273 patients were recruited in this research. Several parameters such as age, diet, family history, BMI, alcohol intake, smoking status et al were analyzed. Patients who had glycosylated hemoglobin less than 6.5% after 52 weeks were considered as having achieved glycemic control and the rest as not achieving it. Five machine learning methods (KNN algorithm, logistic regression algorithm, random forest algorithm, support vector machine, and XGBoost algorithm) were compared to evaluate their performances in prediction accuracy. R 3.6.3 and Python 3.12 were used in data analysis.

Results

The statistical variables for which p< 0.05 was obtained were BMI, pulse, Na, Cl, AKP. Compared with the other four algorithms, XGBoost algorithm has the highest accuracy (Accuracy=99.54% in training set and 78.18% in testing set) and AUC values (1.0 in training set and 0.68 in testing set), thus it is recommended to be used for prediction in clinical practice.

Conclusion

When it comes to future blood glucose level prediction using machine learning methods, XGBoost algorithm scores the highest in effectiveness. This algorithm could be applied to assist clinical decision making, as well as guide the lifestyle of diabetic patients, in pursuit of minimizing risks of hyperglycemic or hypoglycemic events.
Big insulin-like growth factor 2-producing multiple solitary fibrous tumors treated with debulking surgery: A case report
Authors: Keidai Yamato , Murakami Takaaki , Yamamura Nana , Tsunoda Shigeru , Ikeda Atsushi , Hida Koya , Nagao Mototsugu , Yamada Yosuke , Fukui Ayaka , Ogura Masahito , Fukuda Izumi , Nakamoto Yuji , Obama Kazutaka , Inagaki Nobuya
Published: January 2023

Background

Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome caused by a tumor-producing high molecular weight form of insulin-like growth factor 2 (IGF2) known as big IGF2. The only curative treatment for this condition is surgical resection of the responsible tumors. However, this may not be feasible in cases with multiple metastases at diagnosis of NICTH, and no standard treatment strategy for multiple tumors has been established. The effects of pharmacological therapies including somatostatin analogs are often inefficient and remain difficult to predict.

Case description

A 68-year-old man was admitted to our hospital due to impaired consciousness and severe hypoglycemia. His medical history included diagnosis of a left temporal solitary fibrous tumor (SFT) at the age of 48 years, after which local recurrent and metastatic tumors were repeatedly resected. Four years before admission, multiple intraabdominal and subcutaneous tumors were detected and, being asymptomatic, were managed conservatively. Laboratory exam on admission demonstrated hypoglycemia accompanied with low serum insulin and IGF1 levels. Computed tomography (CT) scan revealed multiple intraabdominal and subcutaneous tumors increasing in size. Serum big IGF2 was detected on immunoblot analysis, and he was diagnosed as NICTH. In addition, tumor uptake was observed on 68Ga-labelled 1,4,7,10-tetraazacyclododecane-N,N’,N’’,N’’’-tetraacetic acid-d-Phe1-Tyr3-octreotide positron emission tomography/CT (DOTATOC-PET/CT). Since larger tumor is more suspicious about responsible producibility of big IGF2, we planned to resect large ones preferentially and reduce the amounts of residual tumors. Debulking surgery was performed by removing eleven intraabdominal tumors; the hypoglycemia was then completely corrected. Histological analyses revealed the resected tumors to be metastases of SFT having somatostatin receptor 2 expression. In immunoblot analysis, the resected tumors were found to be positive for big IGF2; serum big IGF2 was undetectable after surgery.

Conclusion

We present a case of NICTH with multiple metastatic SFTs. We strategically performed debulking surgery, which led to remission of hypoglycemia. This result demonstrates a pioneering practical solution for NICTH cases with multiple tumors. In addition, in cases of SFTs presenting with NICTH, positivity of DOTATOC-PET/CT as well as single-dose administration of octreotide may be predictive of the efficacy of somatostatin-based therapy.
A real-world study of anlotinib combined with GS regimen as first-line treatment for advanced pancreatic cancer
Authors: Zhan Gouling , Hu Jianbing , Da Shijian , Weng Jie , Zhou Chuanyi , Wen Fang , Liu Songlian , Fang Fang , Shen Erdong , Zhou Qiang , Luo Pan , Xu Min , Zhan Dahe , Su Yuqi
Published: January 2023

Background

Anlotinib may boost the efficacy of pancreatic cancer (PC) treatment if timely added to the GS regimen (Gemcitabine, Tegafur-gimeracil-oteracil potassium); however, no data has been published. This study evaluated the safety and efficacy of anlotinib in combination with the GS regimen(hereafter referred to as the A+GS regimen) in the first-line treatment of patients with unresectable or metastatic PC.

Methods

Patients with unresectable or metastatic PC treated at Yueyang Central Hospital and Yueyang People’s Hospital between October 2018 and June 2022 were enrolled in this retrospective real-world investigation. Treatment efficacy was evaluated based on the overall survival (OS), progression-free survival (PFS), disease control rate (DCR), and objective response rate (ORR), while the treatment safety was assessed by the frequency of major adverse events (AEs).

Results

Seventy-one patients were included in this study, 41 in the GS group and 30 in the A+GS group. The A+GS group had a longer mPFS than the GS group (12.0 months (95% CI, 6.0–18.0) and 6.0 months (95% CI, 3.0–8.1)), respectively (P = 0.005). mOS was longer in the GS+A group) when compared with the GS group (17.0 months (95%CI, 14.0–20.0) and 10.0 months (95% CI, 7.5–12.5)), respectively (P = 0.018). The GS+A group had higher ORR (50.0% vs 26.8%, P = 0.045) and DCR (83.3% vs 58.5%, P = 0.026). Furthermore, there were no grade 4-5 AEs and no treatment-related deaths, and no discernible increase in AEs in the GS+A group when compared with the GS group.

Conclusion

The A+GS regimen therapy holds great promise in managing treatment-naive advanced PC, except that future prospective studies with larger sample sizes and multiple centers are required to determine its efficacy and safety.