bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGOLAHAN BIJI ALPUKAT (Persea americana) UNTUK DIJADIKAN TEPUNG SEBAGAI BAHAN DASAR PANGAN BESAR
Authors: Azhar Amsal  , Tika Agustina  , Nurhaliza  , Barisah
Published: July 2023

Pada umumnya alpukat hanya dimanfaatkan daging buahnya sedangkan kulit dan biji nya menjadi limbah terbuang. Pemanfaatan limbah dari alpukat dilakukan agar tidak dibuang begitu saja. Salah satu limbahnya ialah biji dari buah alpukat. Pengolahan yang diupayakan merupakan salah satu upaya untuk bisa memanfaatkan biji buah alpukat seperti pembuatan tepung. Tujuan dilakukannya penelitian ini untuk memanfaatkan limbah biji alpukat menjadi tepung. Metode yang digunakan untuk penelitian ini yaitu kuantitatif deskriptif. Hasil pengolahan menunjukkan jika tepung memiliki tekstur yang lembut dan halus setelah disaring. Tepung berwarna coklat dan tidak memiliki aroma yang khas. Nilai rendemen yang dihasilkan ialah 23,5 %.
Productive Uneasiness as a Driver of Knowledge Creation Processes in Humanities-Business Collaborations
Authors: Tjørring Lise , Mahnke Martina Skrubbeltrang , Petersen Matilde Lykkebo , Nielsen Mikka , Vacher Mark
Published: July 2023

Over the last few decades, Danish humanities researchers have become increasingly expected to engage in business collaborations that have an impact beyond academia. Although there is great willingness to work together, humanities-business collaborations are often tense affairs. This calls for a deeper understanding of the collaboration and knowledge creation processes. In this article, we develop the concept of productive uneasiness as a sensitizing tool to show how humanities scholars enable specific knowledge engagements. Examining three empirical examples, we discuss how emerging tension, discomfort, and the like come into play in business-humanities collaborations, and how accepting and engaging in this uneasiness can become productive, eventually leading to innovation. The aim of the article is to provide a tool for reflection for humanities and social science researchers wishing to engage in humanities-business collaborations and, more generally, to spark a discussion on how one of the core elements of the humanities – in-depth analysis of the intangible – can leverage business processes.
Selling Thrift: Work Practices in an American Thrift Store
Authors: Larsen Frederik
Published: July 2023

Thrift, in its simplest definition, is the practice of using resources in a considered way. The concept has long been employed as a moral trope to condemn or promote a variety of human practices. In the literature, thrift is addressed as it is played out in consumption in and around the household as a way of preserving and saving resources. Thrift stores form part of a thrift economy and, as the receiver of divested objects from the household and a site for thrifty consumption practices, they present aspects of thrift in a variety of ways. In this article, I look at thrift as it relates to work and organizational practices in an American thrift store. Although often linked to work ethics, thrift has mainly been proposed as a moral concept guiding individual and not organizational practices. In order to explore the value of thrift in the thrift store, I present parts of my ethnographic research on second-hand markets. Examining work practices as “thrifty” shows how economic prudence is paired with material frugality and community concern. This, I argue, has significant effect on the flow of consumer goods, as resources flow through the thrift store and appear to be spent, not saved.
The Value of Diversification, Managerial Ability and Corporate Governance: Evidence from Malaysian Firms
Authors: Lee Chyn-Hwa , Foong Swee-Sim
Published: July 2023

Manuscript type: Research paper Research aims: This paper examines the moderating effect of managerial ability on the relationship between diversification and firm value. Design/Methodology/Approach: The analysis is based on all KLSE-listed firms across nine sectors over the period of 2009 to 2017 using panel regression. Research findings: High-ability managers increase Tobin’s q. Managerial ability changes the diversification-firm value relationship from negative to significantly positive. Managerial ability, in terms of governance mechanism, CEO age, and education background, has a positive moderating effect on the value outcome of diversification. Theoretical contribution/Originality: This study is one of the first to link resource-based perspective and outcome of diversification, and find a moderating relationship between diversification and firm value. It contributes to resource-based theory, highlighting that accumulated human capital is a valuable strategic resource for a firm. The results also contribute to the corporate governance literature and provide support for upper echelons theory. Practitioner/Policy implication: The findings are valuable to diversified firms in understanding the effect of managerial ability on the outcome of diversification. Diversified firms that hire older CEOs with better education, practise separate leadership structures, and have a mostly independent board are more likely to benefit from diversification. Research limitation/Implications: This study uses only one proxy for managerial ability. Second, firms are grouped by industry to compare efficiency. However, firms in the same industry can have quite varied inputs and outputs depending on their asset and operation mix.
A Five-Factor Asset Pricing Model of Shariah Compliant Firms in the United States
Authors: Abdul Halim Asyraf
Published: July 2023

Shariah compliant firms operating in an environment with little to no access to a robust Islamic capital market (such as in the United States (US) stock market) will exhibit a consistent bias towards certain corporate financial behaviour. Does this bias subsequently lead to a skewed asset pricing behaviour? To answer this question, this paper investigates the asset pricing behaviour of multiple samples of Shariah compliant firms listed in the US as compared to an overall conventional sample by employing the Fama & French Five-Factor Model. By applying contemporary Shariah stock screening methodology on a sample of all stocks listed in the NYSE, NASDAQ and the IEX from January 2000 to December 2019, this paper shows that asset pricing behaviour differs not only between Shariah compliant and conventional samples, but also amongst Shariah compliant samples themselves. Ultimately, this paper shows that when deriving the appropriate expected return for Shariah compliant portfolios in the US, there are evidence to suggest that the Fama & French Five-Factor model is more suitable compared to the traditional Capital Asset Pricing Model (CAPM) since the additional risk premiums show consistent significance across groups of Shariah compliant firms.
Income Inequality, Income Growth and Government Redistribution in Malaysia: What Do We Know in the Long Run?
Authors: Goh Soo Khoon , Wong Koi Nyen , Kartinah Ayupp , Lai You Wah
Published: July 2023

Malaysia has a good track record of reducing income inequality, especially between ethnic groups. In recent years, increasing attention has been paid to national inequality – notably by targeting the bottom 40% income group while sustaining growth with inclusivity. This paper uses the latest cointegration technique, namely, the augmented autoregressive distributed lag (A-ARDL) to examine the long-run determinants of income inequality in Malaysia. The long-run results suggest that income inequality is negatively driven by real GDP per capita and government redistribution of income. The findings provide some possible policy implications that could reduce income inequality in the long run, in particular, through the enhancement of the quality and skills of the workforce, and the government’s benevolent role by using redistributive instruments such as progressive income tax and cash transfers to low-income groups.
Supporting SMEs Financial Resilience during Crises: A Framework to Evaluate the Effectiveness of Financial Literacy Programs Targeting SMEs
Authors: Dalal Aassouli , Habib Ahmed
Published: July 2023

Financing capital investments and working capital have been the key challenges for small businesses during and in the aftermath of the pandemic. Excessive indebtedness can increase the fragility of firms, particularly during times of uncertainty. While there are several programs globally that target entrepreneurs’ financial literacy, most of them do not take into consideration entrepreneurs’ financial resilience during and after crisis times such as pandemics. The objective of this paper is to discuss the status of financial literacy programs targeting entrepreneurs. This paper conducts a review of the relevant literature to establish the initial understanding and then generates a framework consisting of entrepreneurs’ financial literacy along with its components. This is done by carrying out qualitative content analysis of the various financial literacy initiatives targeting entrepreneurs in twenty countries globally to understand their target segments, scope, initiating organisations and limitations. The paper then suggests a framework for entrepreneurs’ financial education that takes into consideration financial resilience during and after crisis situations in general and pandemics in particular.
Core-Shell Structured Lanthanide-Doped Lead-Free Double Perovskite Nanocrystals with Dual-Mode Downshifted and Upconversion Luminescence for Encryption and Data Storage
Authors: Cui Endian , Yuan XiangYang , Zhang Yi , Artizzu Flavia , Liao Xiaoling , Tang Jianfeng , Zhao Yanan , Zhao Pengzhou , Liu Yingshuai , Liu Kai , Liu Jing
Published: July 2023

Metal ion doping is the most viable method to modulate the optical
properties of lead-free Cs2AgInCl6 double perovskite (DP) nanocrystals
(NCs). However, despite multiple cations doping can allow for emission
color tuning, their random distribution into the perovskite matrix poses
severe limits caused by uncontrollable and adverse energy interactions
between the dopants, resulting in poor emission color purity and
photoluminescence (PL) quenching. To address this issue, we designed
Cs2AgInCl6-based core-shell NCs doped with different metal ions in the
two layers via an epitaxial growth strategy, with the aim to spatially
separate the diverse optically-active centers. We selected Cs2AgInCl6:Bi
as the core and Cs2AgInCl6:Yb, Er as the shell, and successfully
constructed Cs2AgInCl6:Bi@Cs2AgInCl6:Yb, Er core-shell NCs. The
so-designed core-shell NCs allow for non-interacting dual-modal
luminescence (upconversion/downshifting) yielding not only broadband
self-trapping excitons orange emission under ultraviolet (UV)
excitation, but also upconversion green light emission under
near-infrared (NIR) excitation, so far unprecedented in DP NCs. Taking
advantage of the high photostability and stability against moisture
bestowed by the shell coating, we demonstrate that the resulting
core-shell DP NCs can be successfully employed as luminescent ink for
dual-mode anti-counterfeiting labels. These results not only provide a
novel design strategy for multi-emissive lead-free NCs, but can also
represent a milestone to realize controllable luminescent materials for
anti-counterfeiting and information storage.
Rare-Earth electrocatalysis: Yttrium- and plasma-enabled YNiCo phospho-nitride hetero-phase nanosheets for high-current water electrolysis
Authors: Xiang Huiyang , Chen Guangliang , Huang Jun , Chen Wei , Chen Zhuoyi , Li Tongtong , Ostrikov Kostya
Published: July 2023

Engineering high-performance and low-cost bifunctional catalysts for H2
(HER) and O2 (OER) evolution under industrial electrocatalytic
conditions remains challenging. Here, we use the stronger
electronegativity of rare-earth yttrium ion (Y3+) to in-situ induce NiCo
layered double hydroxide (LDH) nanosheets from the NiCo foam (NCF)
treated by a dielectric barrier discharge plasma (PNCF), and then obtain
a nitrogen-doped YNiCo phosphide (N-YNiCoP/PNCF) after the phosphating
process using RF plasma in nitrogen. The obtained N-YNiCoP/PNCF has a
large specific surface area, rich heterointerfaces and the optimized
electronic structure, causing a high electrocatalytic activity in HER
(331 mV Vs 2000 mA cm-2) and OER (464 mV Vs 2000 mA cm-2) reactions in
1M KOH electrolyte. The X-ray absorption spectroscopy (XAS) and DFT
quantum chemistry calculations reveal that the coordination number of
CoNi decreased with the incorporation of Y atoms, which cause a much
shorter bonds of Ni and Co ions and achieving a long-term stability of
N-YNiCoP in HER and OER under the simulated industrial conditions.
Meanwhile, the CoN-YP5 heterointerface formed by the plasma N-doping is
the active center for overall water splitting. This work opens a new
direction for designing high-performance rare-earth elements into
engineering bifunctional electrocatalysts in the renewable energy field.
Assessment of The Correlation Between Doppler Derived dP/dt and Aortic Velocity-time Integral During Cardiac Resynchronization Therapy Optimization
Authors: Ekinci Selim , Uzun Hakan Gökalp
Published: July 2023

Suboptimal response to cardiac resynchronization therapy (CRT) may be
improved by optimization of device parameters using echocardiography.
For this purpose, the aortic velocity-time integral (aVTI) was used as a
target metric to define optimal velocity timings for each ventricle.
dP/dt is a parameter used for the assessment of myocardial
contractility. In this study, we aimed to evaluate the effectiveness of
Doppler-derived dP/dt in optimization by assessing the possible
correlation between aVTI and dP/dt. Patients with CRT admitted for
routine follow-up were included in the study. Aortic VTI and dP/dt
measurements were recorded in four different standard pacing
configurations during reprogramming. A total of 46 patients were
included in the final analysis. No correlation was found between the
aVTI and the delta dP/dt value in the two configurations where the
change in dP/dt was maximum (p=0.894). In the two configurations where
the change in aVTI was maximum, there was also no correlation between
the delta dP/dt and the delta aVTI (p=0.715). When patients were
dichotomized according to the median value of dP/dt, there were no
differences in aVTI, NYHA classes, LVEF, and mitral regurgitation (MR)
severity (p=0.4; p=0.5; p=0.7; p=0.3; respectively). The change in both
dP/dt and aVTI was statistically significant when switching from RV-only
to QRS width-targeted configuration (p=0.001; p=0.041; respectively). In
conclusion, aVTI recorded at different pacing configurations was not
correlated with dP/dt during interventricular optimization. However,
both parameters consistently showed a positive effect of biventricular
pacing on contractile synchronization and stroke volume.
A SUCCESS STORY OF AN INFANTILE ANAPLASTIC LARGE CELL LYMPHOMA --A CASE REPORT.
Authors: J Sowmya , Kumar Nuthan , Kaushik Prakruthi , Kumar Arun , T Avinash , BS Arunakumari , L Appaji
Published: July 2023

Background: Anaplastic large cell lymphoma (ALCL) is an uncommon form of
Non-Hodgkin Lymphoma (NHL) in younger patients, accounting for less than
15% of cases. The median age at presentation is 12 years and is
exceedingly rare in infants. Various prognostic factors, risk
stratification and novel treatment strategies have been studied in
pediatric ALCL. There is no separate data available on the disease
biology, treatment regimens and prognostic factors among infantile ALCL.
Outcomes for infants with ALCL have been reported to be inferior to that
of older children. The long-term Event Free Survival (EFS) in general
among pediatric patients is approximately 70% regardless of the
treatment approach. We report a case of an 8month old infant diagnosed
with ALK positive ALCL with visceral organ involvement stratified as
high risk and treated according to ALCL 99 protocol with excellent
clinical response, on regular follow up and is disease free since
2years.
Adaptive fuzzy event-triggered fault-tolerant control of switched nonlinear systems with actuator failures under state-dependent switchings
Authors: Li Shi , Zhang Ronghao , Chen Yongsheng , Liu Ye
Published: July 2023

In this paper, an adaptive fuzzy event-triggered control (ETC) problem
of switched nonlinear systems (SNSs) under actuator failures is studied.
Fuzzy logic systems (FLSs) are introduced to approximate the unknown
nonlinear terms of the system. To reduce the wastage of communication
resources (WCRs), an adaptive fuzzy event-triggered mechanism (ETM) with
a state-dependent switching law is designed. In order to ensure the
stability of whole systems, the convex combination technology is
adopted. The dynamic surface control method is employed to deal with the
problem of ‘curse of dimensionality’. Additionally, a single Lyapunov
function is constructed to analyze the stability of the system. It is
proved that all signals of the closed-loop system (CLS) are bounded.
Finally, the effectiveness of the method is verified by simulation
results.
Improving the solar cell efficiency by using cooling techniques
Authors: Abed Raad Hamzah , ghaydh nabeel A.
Published: July 2023

The research investigates the usage of fins fastened to a solar panel’s
rear surface for passive cooling purposes. In the research, solar
modules with air conditioning were compared to modules with connected
fins acting as a heat sink to cool them. The former served as the
benchmark for comparison. The research explores two approaches for
cooling modules with fins: ventilation air and still air. The research
looked at the heat transfer by photovoltaic panels with and without fins
to examine the effects of the environment and solar radiation on the
performance of solar cells. The inquiry was carried out ostensibly.
According to the findings, the use of fins for cooling reduced cell
temperature and improved electrical and thermal efficiency. The
estimated performance values of PVT solar cells obtained by using the
COMSOL software and the experimental tests carried out during the
daytime were reasonably in accord. At midday, the cell temperature
decreased by a maximum of 2.8 C , while electrical
and thermal efficiency increased by a maximum of 18.2% and 55.13%,
respectively. Good agreement between experimental and numerical results.
Genomic basis of melanin-phenotypes indicates colour-specific environmental adaptations in tawny owls
Authors: Baltazar-Soares Miguel , Karell Patrik , Wright Dominic , Nilsson Jan-Åke , Brommer Jon
Published: July 2023

Feathers comprise a series of evolutionary innovations but also harbor
colour, a biological trait with immense selective value and known to
co-vary with life history or complex traits. Such an intricate web of
relationships is particularly true in melanin-based pigmentation
species, mainly due to known pleiotropic effects of the melanocortin
pathway – originating so-called melanin-phenotypes. Here we explored
the molecular basis of melanin coloration and expected co-variation at
molecular level in a melanin-based, colour polymorphic benchmark system,
the tawny owl. An extensive body of literature has revealed grey and
brown tawny owl color morphs differ in a series of life history and
behavioral traits. We assembled the first draft genome of the species
against which we mapped ddRADseq reads from 220 grey and 150 brown
morphs - representing 10 years of pedigree data from a population in
Southern Finland - and explored genome-wide associations with colour
phenotype. Our results revealed molecular signatures of cold adaptation
strongly associated with grey coloration, namely a non-synonymous
substitution in MCHR1 detected when comparing genomes, plus 2
substitutions in non-coding regions of FTCD and FAM135A whose genotype
combinations obtained a predictive power of up to 100% (predicting grey
colour). All these genes have functions related to energy homeostasis,
fat deposition and control of starvation response and indicate the
molecular basis of some cold environment adaptations predicted to be
grey-morph specific. our results unveil part of the molecular machinery
of melanin-phenotypes and shed light on the maintenance and evolution of
colour polymorphism in melanin-based pigmented species.
Phenotypic characterization of the Rwandan stinging nettle (Urtica massaica Mildbr.) with emphasis on leaf morphological differences.
Authors: Nduwamungu Jean , Munyandamutsa Philippe , Senyanzobe Jean Marie Vianney , Ruhimbana charles , Ugirabe Marie Aurore , Mahoro Janvier , Dusingize Marie Christine , Karungi Mary , Irimaso Emmanuel , Maniraho Eric , Nsabimana Phenias , Mugunga Canisius , Mugemangago Cyprien
Published: July 2023

Phenotypic characterization of the Rwandan stinging nettle (Urtica
massaica Mildbr.) with emphasis on leaf morphological differences.
Authors : Nduwamungu, J.1, Munyandamutsa, P.1, Senyanzobe, J.M.V.1,
Ruhimbana, C.1, Ugirabe, M.A1, Mahoro, J1., Dusingize, M.C1., Kabarungi,
M.1, Irimaso, E.1, Maniraho, E1., Nsabimana, P.1, Mugunga, C.1, and
Mugemangango, C.2 1. College of Agriculture, Animal Sciences and
Veterinary Medicine 2. College of Sciences and Technology. Corresponding
author: nzobe2020@gmail.com Abstract Patterns of intraspecific variation
based on environmental conditions in which populations live may reflect
adaptive responses to their habitat. The Rwandan stinging nettle plant
grows in most parts of Rwanda both in the wild and domestication forms.
While the plant can easily be identified through its leaves and life
form, it has been observed that the leaf morphology slightly varied from
one region to another. This study aimed to investigate morphological
variations, particularly in leaf morphology of the Rwandan stinging
nettle growing in the lowland, midland, and highland. Specimens of the
stinging nettle were taken from different sites located in the three
altitudinal zones. Plant heights and leaf lengths varied from one site
to another and the statistical analysis revealed that the average plant
heights, as well as leaf lengths of mature stinging nettle samples from
highland, midland, and lowland, were significantly different. The
results showed that there were morphological differences, particularly
in leaves among the three altitudinal zones. The most prominent
difference was in the main vein of the stinging nettle. Changes in leaf
morphology can be linked to differences in environment and nutrient
availability between the three habitats which could have enabled the
species to evolve differently. However, the genetic basis of these
phenotypic changes needs to be examined in future research to establish
their heritability for future populations of the stinging nettle plant
in Rwanda. Key words: Morphometrics, stinging nettle, traits, habitat,
Rwanda.
Discovery of the covalent SARS-CoV-2 M pro inhibitors from anti-viral herbs via integrating target-based high-throughput screening and chemoproteomic approaches
Authors: Ge Guang-Bo , Zhang Ya-Ni , Zhu Guang-Hao , Liu Wei , Chen Xi-Xiang , Xie Yuan-Yuan , Xu Jian-Rong , Jiang Mei-Fang , Zhuang Xiao-yu , Zhang Wei-Dong , Chen Hong-Zhuan
Published: July 2023

The main proteases (M ) are highly conserved
cysteine-rich proteins that can be covalently modified by numerous
natural and synthetic compounds. Herein, we constructed an integrative
approach to efficiently discover covalent inhibitors of M
from complex herbal matrices. This work begins
with biological screening of sixty clinically used antiviral herbal
medicines, among which Lonicera japonica (LJ) demonstrated the
strongest anti-M effect (IC =
37.82 μg/mL). Mass spectrometry-based chemical analysis and
chemoproteomic profiling revealed that LJ extract contains at least 50
constituents, of which 22 exhibited the capability to covalently modify
M . We subsequently verified the anti-M
effects of these covalent binders. Gallic acid and
quercetin were found to potently inhibit SARS-CoV-2 M
in dose- and time- dependent manners, with the IC
values below 10 µM. The inactivation kinetics,
binding affinity and binding mode of gallic acid and quercetin were
further characterized by fluorescence resonance energy transfer, surface
plasmon resonance, and covalent docking simulations. Overall, this study
established a practical approach for efficiently discovering the
covalent inhibitors of M from herbal medicines by
integrating target-based high-throughput screening and mass
spectrometry-based assays, which would greatly facilitate the discovery
of key anti-viral constituents from medicinal plants.
The clinical utility of elective flexible bronchoscopy to improve outcomes for children: a systematic review.
Authors: J Rahul Thomas , Yerkovich Stephanie , Goyal Vikas , Chang Anne , Rutter Cameron , Masters Ian , Marchant Julie
Published: July 2023

Introduction: Elective flexible bronchoscopy (FB) is now widely
available and standard practice for a variety of indications in children
with respiratory conditions. However, there is limited evidence
regarding the utility of elective FB in children. This systematic review
aimed to determine the utility of FB on its impact in clinical decision
making and patient-reported outcome measures (PROMs). Methods:
We searched Pubmed, Cochrane central register of controlled trials,
Embase, World Health Organisation Clinical Trials Registry Platform and
Cochrane database of systematic reviews from inception to 20
April 2023. We included systematic reviews (SRs)
and randomised controlled trials (RCTs) that used parallel group design
(comparing use of elective FB versus no FB, or a wait-list approach
[early FB versus usual wait FB]) in children aged ≤ 18 years. Our
protocol was prospectively registered and used Cochrane methodology for
systemic reviews of interventions. Results: Our search
identified 859 articles; 102 duplicates were removed, and 753 articles
were excluded by title and abstract. Four full text articles were
reviewed and subsequently excluded, as none met the inclusion criteria
outlined in our PICO framework. Conclusions: Given the paucity
of data, there is need for high-quality evidence to support the routine
use of elective FB in children with respiratory conditions. We recommend
clinicians adhere to current international guidelines until such
evidence emerges. Registration: PROSPERO CRD42021291305.
Proteomic Analysis in the Histodifferentiation Process during the Recalcitrant Seed Development of Artocarpus hirsutus. Lam
Authors: S Sreedevi , Kumar K.G.Ajith , Amritha V.V , John Sneha
Published: July 2023

Artocarpus hirsutus Lam. is a tropical evergreen recalcitrant tree
species. The seed development is marked by the histodifferentiation
phase which is highly complicated by the interaction of a variety of
proteins involved in embryo expansion and differentiation. For a better
understanding of the physiology and biochemistry of this process,
protein expression profiling was carried out by SDS-PAGE followed by
LC-MS/MS technique. 410 proteins could be identified from the spectral
data belonging to different classes viz. cell division, metabolism,
stress, transport, folding, hormone metabolism etc. Simultaneous
analysis of Plant growth regulators (PGRs) by LC-MS/MS technique
revealed that IAA, GA4, trans-Zeatin (tZ), ABA, Jasmonic acid (JA),
Epibrasinolide (24epiBl) and salicylic acid (SA) were found to be in
elevated levels in the young embryos. However, proteome analysis only
showed JA biosynthetic proteins. Results indicate that most of the PGRs
involved in histodifferentiation process of recalcitrant embryo
development is provided by the maternal tissue rather than de-novo
synthesis in young embryo, a possible answer to a much debated question.
Comparison of seeds to analyse protein expression during
histodifferentiation in Artocarpus hirsutus with Phaseolus vulgaris
showed almost similar processes are happening in both the species.
However the accumulation of some proteins showed different pattern.
Proteomics Analysis of Porcine Kidney Cell Lines LLC-PK1 and PK15 with Different PEDV Infectivity
Authors: Jin Deng , Xinna Ge , Jun Han , Lei Zhou , Ning Zhang Yong , Xin Guo , Yang Han Chun
Published: July 2023

The screening and identification of porcine epidemic diarrhea virus
(PEDV) host restriction factors are of great significance for the
prevention, control and treatment of porcine epidemic diarrhea (PED),
but due to the lack of a suitable research platform, this field has been
progressing slowly. In this study, label-free liquid
chromatography-tandem mass spectrometry (LC-MS/MS) was used to
quantitatively identify the differentially expressed proteins (DEPs)
between porcine kidney cell lines LLC-PK1 and PK15, whose susceptibility
to PEDV was distinct. We identified 118 and 69 specific expressed
proteins (fold changes >20 and with p < 0.05) in
LLC-PK1 and PK15 cells, respectively. In addition, another 1138 DEPs,
including 652 upregulated and 486 downregulated proteins, were
identified in LLC-PK1 cells. Alterations in the expression of selected
proteins were verified by western blot. Bioinformatics analyses,
including GO, KEGG, and STRING, further demonstrated that the DEPs are
involved in numerous crucial biological processes and signaling
pathways, such as organelle organization, nucleotide binding, phagosome,
lysosome, focal adhesion pathways and metabolic pathways. Altogether,
this is the first proteomic study of porcine cell lines with high
homology but different infectivity to PEDV, which shall provide valuable
clues for further investigation of PEDV pathogenesis.
Time Trends in the Incidence of Diabetic Ketoacidosis Leading to Hospital Admission Among Adults With Type 1 Diabetes: A Nationwide Danish Register Study
Authors: Stougaard Elisabeth B. , Amadid Hanan , Søndergaard Esben , Carstensen Bendix , Jørgensen Marit E. , Nørgaard Kirsten , Rossing Peter , Persson Frederik , Vistisen Dorte
Published: July 2023

OBJECTIVE

Diabetic ketoacidosis (DKA) is a life-threatening but preventable complication in people with type 1 diabetes. We aimed to quantify the incidence of DKA according to age and describe the time trend of DKA among adults with type 1 diabetes in Denmark.

RESEARCH DESIGN AND METHODS

Individuals aged ≥18 years with type 1 diabetes were identified from a nationwide Danish diabetes register. Hospital admissions due to DKA were ascertained from the National Patient Register. The follow-up period was from 1996 to 2020.

RESULTS

The cohort consisted of 24,718 adults with type 1 diabetes. The incidence rate of DKA per 100 person-years (PY) decreased with increasing age for both men and women. From 20 to 80 years of age, the DKA incidence rate decreased from 3.27 to 0.38 per 100 PY. From 1996 to 2008, the incidence rate of DKA increased for all age-groups, with a subsequent minor decrease in incidence rate until 2020. From 1996 to 2008, the incidence rates increased from 1.91 to 3.77 per 100 PY for a 20-year-old individual and from 0.22 to 0.44 per 100 PY for an 80-year-old individual living with type 1 diabetes. From 2008 to 2020 the incidence rates decreased from 3.77 to 3.27 and from 0.44 to 0.38 per 100 PY, respectively.

CONCLUSIONS

The incidence rates of DKA are declining for all ages, with an overall decline from 2008 for both men and women. This likely reflects improved diabetes management for individuals with type 1 diabetes in Denmark.
Glycemic Measures in Childhood as Predictors of Future Diabetes Related Microvascular Complications in an Indigenous American Population
Authors: Vazquez Laura , Vazquez Arreola Elsa , L. Hanson Robert , Sinha Madhumita
Published: July 2023

OBJECTIVE 

To examine the role of glycemic measures performed during childhood in predicting future diabetes related nephropathy and retinopathy in a high-risk indigenous American cohort. 

RESEARCH DESIGN AND METHODS

We studied associations between glycated hemoglobin (HbA1c) and 2-hour plasma glucose (2-hr PG), measured during childhood (5-<20 years) in a longitudinal observational study of diabetes and its complications (1965-2007) with future albuminuria [Albumin creatinine ratio (ACR)≥30 mg/g], severe albuminuria (ACR≥300 mg/g), and retinopathy (at least one microaneurysm or hemorrhage or proliferative retinopathy on direct ophthalmoscopy). Areas under the ROC curve (AUC) for childhood glycemic measures when predicting nephropathy and retinopathy were compared. 

RESULTS

Higher baseline levels of HbA1c and 2-hr PG significantly increased risk of future severe albuminuria [(HbA1c: HR=1.45 per %, 95% CI: 1.02-2.05) and (2-hr PG: HR=1.21 per mmol/L, 95% CI: 1.16-1.27)]. When categorized by baseline HbA1c, children with prediabetes had higher incidence of albuminuria (29.7 cases/1,000 PY), severe albuminuria (3.8 cases/1,000 PY) and retinopathy (7.1 cases/1,000 PY) than children with normal HbA1c levels (albuminuria: 23.8 cases/1,000 PY; severe albuminuria: 2.4 cases/1,000 PY; retinopathy: 1.7 cases/1,000 PY); children with diabetes at baseline had the highest incidence of the three complications. No significant differences were observed between AUCs for models with HbA1c, 2-hr PG, and FPG when predicting albuminuria, severe albuminuria, or retinopathy.

CONCLUSIONS

In this study, higher glycemia levels ascertained by HbA1c and 2-hr PG during childhood were associated with future microvascular complications; this demonstrates potential utility of screening tests performed in high-risk children in predicting long-term health outcomes.
Designing Cloud Chamber for Simulate the Microphysics Processes in the Formation of Ice Crystals
Authors: Azeez Hasan M. , Khalaf Monim Hakeem , Degan Eptehaal M. , Robaa S. M.
Published: July 2023

The simulate microphysical processes in the atmosphere, a cloud chamber, which behaves as the atmosphere, has been designed and fabricated in order to be used to execute several atmospheric experiments. These experiments allow a better understanding of clear visual cloud formation. The executed temperature and saturated pressure experiments clarify the basic mechanisms of the ice crystals nucleation, which in contrast, represent the core of the cloud microphysics. The cloud chamber can represent an isolated environment that deals with a certain volume of pure air and contains certain nucleation particles or ice nuclei. The temperature range in such a chamber is similar to that found at the mid-latitudes between the surface of the earth and the top of the troposphere. Thus, it is possible to simulate clouds of the type of Cirrostratus at the bottom of the chamber. It has been designed with dimensions of 22×22×59 cm3 and made of 3mm in thickness copper with a purity of 99.9%, and thermal conductivity of 401 W/m.°K.
Frequency of Hypomagnesemia in Patients with Hypokalemia Admitted in A Tertiary Care Hospital
Authors: Romel Md Sazzad Hosen , Afrin Rezowana
Published: July 2023

Deficiencies of electrolytes (hypokalemia and hypomagnesemia) are of clinical importance in hospitalized patients. Hypomagnesemia is often associated with hypokalemia and concomitant hypomagnesemia potentiates hypokalemia and makes it difficult to treat with potassium replacement alone. Therefore, the aim of this study was to evaluate the frequency of hypomagnesemia in hypokalemic patients admitted in a tertiary care hospital. Total 75 patients with admission hypokalemia (serum potassium <3.5 mmol/l) were approached for inclusion in the study. Overall frequency of hypomagnesemia (serum Mg2+ level <0.66 mmol/L) were present in 58.7% (n=44) patients. A positive correlation was observed between serum level of potassium and magnesium in our study population. (Pearson’s correlation co-efficient, r=0.801, P <0.001). However, before any final comment further multicenter study is recommended.
Kajian Analisis Faktor pada Faktor yang Mempengaruhi Produksi Padi di Nagari Cupak Kabupaten Solok
Authors: Aisy Rohadatul , Sari Devni Prima
Published: July 2023

Solok district is the largest rice producing center in West Sumatra, known as "Bareh Solok", with most of the population working as farmers. Increased production is influenced by factors such as land area, labor, seeds, fertilizers, capital, pesticides, and irrigation. These seven factors are interconnected and related to each other, so the purpose of this study was to determine the factors that influence rice production in Nagari Cupak, Gunung Talang District, Solok Regency. The type of research used is applied research. This study has a sample of 89 respondents. Furthermore, in the analysis using factor analysis method. The results of this study indicate that the first factor consists of land area, labor, seeds and pesticides. The second factor consists of fertilizer, capital and pesticide variables
Optimasi Rata-rata Produksi Jagung di Kabupaten Limapuluh Kota Menggunakan Pemrograman Kuadratik Metode Wolfe
Authors: Fitri Sari , Helma Helma
Published: July 2023

This research was an experimented research that purpose to form a mathematical model for optimizing average corn production in Fifty Cities District with the constraint that the harvested area should not be more than the planted area and solve the model with the Wolfe quadratic programming method. The model of mathematical in the research was a model by formed nonlinear using the method of least squares. Then use the Wolfe method to form a new linear objective function and constraints in the form of Karush Kuhn-Tucker conditions. The results showed that the optimal average corn production in Fifty Cities District was 49.00456 tons/Ha with an optimal corn harvest area of 656.256 Ha.
Klasifikasi Masyarakat Penerima BPNT Program Sembako 2021 di Kelurahan Tiakar dengan Mengunakan Metode KNN Classifier
Authors: Nufus Annisa Hidayatul , Helma Helma
Published: July 2023

At the time of the implementation of the food program in the Tiakar Sub-District, there was no information available on the criteria that would make the head of a family eligible to be a recipient of assistance, even though this was very important so that the government's goal of fulfilling the need for nutritious food could be felt by those who really needed it. The purpose of this study was to classify the heads of families in Tiakar Subdistrict as eligible or not eligible to receive staple foods using the K-Nearest Neighbor method. This study uses interview data conducted with the heads of families in the Tiakar Village. The data analysis step is to divide the data into training data and test data by 80%:20%, determine the number of nearest neighbours, calculate the dissimilarity distance and choose a class, calculate the level of accuracy using the confusion matrix and then choose the optimal K. Based on the results of the study, it was found that the K value that was good to use in the classification of family heads in Tiakar Subdistrict was K=3 because it had an accuracy percentage of 95%.
Model Matematika Penyebaran Penyakit Infeksi Saluran Pernapasan Akut (ISPA) Berdasarkan Lokasi Anatomi Akibat Bakteri Streptococcus Pneumoniae
Authors: Leris Diana , Rosha Media
Published: July 2023

Streptococcus pneumoniae is a bacterium that attacks the human respiratory tract. Streptococcus pneumoniae bacteria cause respiratory diseases in the form of pneumonia, otitis media, sinusitis, sepsis, peritonitis, and abscesses. The purpose of this study was to establish, analyze, and interpret the mathematical model of the spread of Acute Respiratory Infections (ARI) based on the anatomical location of the Streptococcus pneumoniae bacteria. In the mathematical population formation model, the human population is divided into six population groups: susceptible, exposes, sinusitis infections, otitis media infections, pneumonia infections, and recovered.  An analysis of the stability of the system around the equilibrium point produces two points, namely, disease-free points, which will be asymptotically stable if βπ<μ(μ+ε+ρ). While the endemic point of the desease will be asymptotically stable if βπ-μ(μ+ε+ρ>0.
Model Matematika Penyebaran Online Compulsive Buying Disorder
Authors: Puspita Lovira , Arnellis Arnellis
Published: July 2023

ABSTRACT Online compulsive buying disorder is a disorder of impulse control when shopping online, so that a person becomes uncontrollable when shopping online and is done repeatedly with a large number of purchases and not so useful. The purpose of this study is to analyze the mathematical model of the spread of online compulsive buying disorder. The method used is the descriptive method. Based on the analysis of the mathematical model of the spread of online compulsive buying disorder, one equilibrium point was obtained, where all eigenvalues of the Jacobi matrix were negative, so that the equilibrium point of the mathematical model of the spread of online compulsive buying disorder was stable asymptotic. This suggests that the spread of online compulsive buying behavior will go towards the equilibrium point over time.
Model Penyebaran Rumor di Media Sosial
Authors: Harista Tasya Salsabilla , Subhan Muhammad
Published: July 2023

Rumors are information that spreads widely without any confirmation of truth and definite facts. One of the media that is used in rumors spreading is social media. The negative impact raised by rumors spreading through social media is the disruption of social stability, economic systems, and politics. The research purpose is to analyze the rumor spreading model on social media. This research is basic research (theoretical) using descriptive methods. The analytical results are obtained of a rumor-free equilibrium point and a rumor spread equilibrium point, each of which is asymptotic stable.  The basic reproduction number obtained by the rumor will spread if the rate of movement of the population of individual who never hear the rumor or counter-rumor increases and became a individual who have been exposed to the rumor or counter-rumor.
A precarização dos direitos da personalidade do trabalhador como consequência da reforma trabalhista
Authors: Carrilho Bernardineli Muriana , Maria Messias da Silva Leda
Published: July 2023

A presente pesquisa objetiva relacionar os direitos da personalidade no meio ambiente de trabalho e a necessidade em promover sua efetiva proteção, os quais nitidamente vem sofrendo crescente precarização em decorrência da reforma trabalhista que ocorreu em 2017 e suprimiu inúmeros direitos do trabalhador. A problemática será direcionada à análise do caráter fundamental do meio ambiente de trabalho e sua relação com uma vida mais digna, assim como será abordado sobre os direitos trabalhistas e da personalidade que foram drasticamente reduzidos com a reforma trabalhista, apresentando quais os prejuízos advieram ao trabalhador com a mencionada reforma, dentre os quais imprescindível mencionar a supressão das horas in itinere, a permissão da redução salarial, aumento da jornada laboral, alterações legislativas no que tange ao acidente de trabalho, concomitantemente com a sobreposição do negociado sobre o legislado, os quais tornam o ambiente de trabalho cada vez mais precarizado e o trabalhador cada vez mais vulnerável ao modelo contemporâneo de relação de trabalho, violando inclusive princípios basilares da relação de trabalho, presentes da Constituição Federal de 1988. Almeja-se ainda depreender sobre a necessidade de tutela dos direitos da personalidade do trabalhador no ambiente laboral e a necessidade de participação de toda a sociedade em sua implementação, considerando ser o ambiente laboral, temática que adentra todos os setores sociais. Menciona-se ainda que foram utilizados para elaboração deste artigo o método histórico e indutivo, pautando-se em documentos físicos e eletrônicos.
O paradoxo da ação antrópica: ser humano causador da destruição florestal e das mudanças climáticas e criador da inteligência artificial para reduzir os efeitos nocivos
Authors: Calgaro Cleide , Reato Talissa Truccolo
Published: July 2023

O problema de pesquisa questiona como que a inteligência artificial pode contribuir para a redução das mudanças climáticas causadas, entre outros fatores, pela destruição das florestas pelos humanos. O objetivo geral é analisar a contribuição da inteligência artificial em prol da redução das mudanças climáticas ocasionadas por vários motivos, entre eles a destruição florestal, tomando em conta que o ser humano ao mesmo tempo em que cria importantes inovações tecnológicas não consegue gerenciar a utilização adequada de recursos naturais. O primeiro objetivo específico visa identificar se a inteligência artificial é capaz de contribuir para a diminuição das mudanças climáticas. O segundo objetivo específico pretende demonstrar como o ser humano não é sensato ao prejudicar as florestas. Quanto aos métodos de pesquisa, a linguagem textual está posta via uma leitura sistemática. Usa-se o método dedutivo. Classifica-se esta pesquisa como básica. É uma análise exploratória. Por fim, com relação aos procedimentos técnicos se trata de uma pesquisa bibliográfica. Conclui-se que o ser humano pode criar máquinas e investir em inteligência artificial, mas precisa contribuir para a redução de mudanças climáticas cessando a interferência antrópica prejudicial, com ênfase na mitigação da destruição das florestas. Assim, a inteligência artificial é uma tecnologia importante, que deve ser somada a normatização, a qual regulamenta as atividades humanas, inclusive punindo atitudes nocivas ao meio ambiente. Além disso, urge estimular a educação ambiental e para o consumo a fim de que existam melhores condições de possibilidade para obter um futuro melhor.
A litigância climática como estratégia de governança: uma alternativa à omissão estatal frente às mudanças climáticas
Authors: Oliveira Alex , Moreira Eliane
Published: July 2023

Este artigo pretende analisar a importância da litigância climática como uma estratégia de governança. Esta litigância pode ser um instrumento eficaz ao enfrentamento das omissões estatais frente à necessidade de concretização de políticas climáticas pois afeta gravemente os direitos humanos e causa uma série violações a estes direitos especialmente pelo seu potencial lesivo aos direitos de populações vulneráveis. Este artigo foi estruturado em busca de uma resposta à seguinte problemática: A litigância climática pode ser considerada uma alternativa eficaz face à omissão estatal frente à adoção de uma política climática mais efetiva? Este artigo possui como objetivo geral demonstrar as vantagens da implementação litigância climática apontando as deficiências da política climática nacional. Em termos metodológicos consiste em um artigo de caráter dedutivo, com pesquisa bibliográfica das principais obras doutrinárias e artigos científicos de doutrinadores nacionais que tratam do tema além da pesquisa possuir um caráter documental analisando determinadas leis que tratam do assunto assim como entendimentos jurisprudenciais das principais cortes do país.
Propriedade Intelectual e Inovação: Um Olhar Político-Constitucional
Authors: Arrabal Alejandro Knaesel
Published: July 2023

Este estudo procura observar a Propriedade Intelectual como vetor de Inovação, sob a ótica Político-Constitucional, ou seja, enquanto projeto, cujas aspirações integram-se ao espectro de valores constitucionalmente resguardados; e enquanto ação, dada a necessária efetividade destes postulados no contexto da sociedade complexa, cujas relações de seus agentes são mediadas por Tecnologias da Informação e Comunicação (TICs). Desenvolvida a partir de uma abordagem sistêmico-dialógica, mais precisamente sob a perspectiva da complexidade abordada por Edgar Morin, a pesquisa apresenta elementos teóricos que procuram contribuir para a observação da Propriedade Intelectual como vetor estratégico de uma Política Constitucional orientada à Inovação. Estruturado em três partes, na primeira o trabalho aborda a diversidade semântica que marca o conceito de Inovação. Na segunda as categorias Criação e Autoria são evidenciadas a partir de revisão teórica que informa seus pressupostos históricos e jurídicos, especialmente em relação ao cotejo entre a legitimidade da autonomia individual e da produção coletiva. Na terceira parte são explorados os conceitos de Propriedade e Propriedade Intelectual para além da exclusividade individualista e segmentação doutrinária, costumeiramente vinculadas a estas categorias. Com especial atenção ao papel das Universidades, a conclusão aponta para o reconhecimento da Propriedade Intelectual como um vetor estratégico para realização de uma política de cariz constitucional voltada à Inovação, a partir da ação destas instituições.