bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Strategi Bersaing Merek Mie Instan Menggunakan Teknik Markov Chain Dan Game Theory (Studi Kasus Mie I Vs Mie S)
Authors: Ridwan Muhammad , Sari Rianita Puspa , Suseno Agustian
Published: September 2021

The Markov chain hypothesis is the hypothesis discussed in stochastic interactions, and has several applications. This strategy is always coordinated with future situations whose whereabouts cannot be known with certainty, so the community tries to carry out exercises with future directions full of vulnerabilities. Hypotheses are numerical ways of dealing with competitive planning situations and the struggles between different interests. This hypothesis is designed to examine the dynamic cycle of various serious states and includes at least two interests. In this situation, the information obtained from the voting results is then assessed for its legitimacy and quality by using the SPSS program. The consequence of counting with Markov chain's S Noodle items reduces the share of the entire industry by 5.8%, while the fun noodle items expands a portion of the entire industry by 41%, the side effect of the game hypothesis being specific. namely X1 with probability 0.5, X2 with probability 0.5 and X3 with probability 3.16. Meanwhile, to limit misfortune, Indomie consolidates three systems, namely Y1 with likelihood - 0.1, Y2 with likelihood 0.5 and Y3 with likelihood 1.
Mengukur Potensi Bahaya dan Resiko Kecelakaan Kerja dengan Metode Hazard and Operabillity Study pada Aktivitas Maintenance
Authors: Dede  , Winarno
Published: September 2021

Work accidents are things that must be avoided, so that's not inflicted loss on the company and the workers. However, several workers still not pay attention to occupational health and safety regulations and in the work area still found several potential hazards. The research is conducted at PT Pindo Deli Pulp and Paper Mills Indonesia in Karawang Regency and focuses on preventive and corrective maintenance activities that prevent paper machine breakdown. The purpose of this study is to measure how big the potential hazard and impact by using Hazard and Operability Study (HAZOP) method. This method is a systematic study, which aims to find the factors that causing work accidents and find out how big the potential accidents and their impacts. The data is collected by distributing questionnaires to the employee. The results show that hazards caused by the work area and the workers themselves are 18% and 82%, respectively. Based on the severity, the number of extreme, high, medium and low risk hazards are 1, 8, 1 and 1, respectively.
Evaluasi Aktivitas Manual Material Handling Dengan Menggunakan Metode Biomekanika Kerja Pada Pengangkatan Thiner di Bagian Warehouse
Authors: Ade Andhika Saputra  , Wahyudin  , Asep Erik Nugraha
Published: September 2021

In doing a job manually such as moving, lifting a certain material needs to be evaluated to minimize the risk of work accidents. The research that will be conducted is the evaluation of manual material handling on the removal and removal of thiners. The purpose of this study was to determine the application of work biomechanics in minimizing the risk of spinal cord injury and providing improvement in work activities. The methods used in this research are Nordic Body Map, NIOSH, Rapid Entire Body Assessment, L5 / S1 (Fc) Force and Energy Consumptions. The results of this study were found that several parts of the workers' body muscles were injured, such as the neck, left and right shoulders, arms and wrists, back and waist. The RWL and Li values ​​after repairs where is RWL exceeded the Load Constant value of 20 kg, and the Li value <1 (no risk). Then the work category level which was originally light-moderate work changed to light work. Furthermore, the original REBA score got a score of 5 to 3 (level 1). And the results of the compressive force against L5 / S1 have values ​​of Fc <AL and Fc < MPL.
Need Identification on Android-Based Neighborhood Electric Vehicle Dashboard View Using The Kano Model
Authors: Fajar Nurhikmah , Wibisono Muh Arif , Kusuma Enas Dhuhri
Published: September 2021

A customer is someone who repeatedly comes to the same place when he wants to buy an item or get service because he is satisfied with the goods or services. Companies must understand the needs and desires of customers in order to satisfy customer needs. Technology that is currently developing is electric cars, especially the Neighborhood Electric Vehicle (NEV) with the application of smartphones. Conventional dashboards can be replaced with smartphones Android-based. Fulfillment of customer satisfaction with smartphone dashboard products is identified by conducting a customer desires survey and categorized it using the Kano model. The survey was conducted on 14 attributes by producing three categories, such as one dimensional, attractive and indifferent. The Android dashboard is built based on survey results instruments. The use of Arduino nano and ESP32 as controllers that process vehicle instrument data sent using Wi-Fi in real time to Android-based smartphones has a maximum error of 5% for speed data.
Feasibility Study of Public Health Center X
Authors: Tambunan Willy , Pawitra Theresia Amelia , Siagian Riko Yehezkiel
Published: September 2021

Public Health Center X is the first level health facility service provider in subdistrict X. Established in 1975, UPT Puskesmas X has never conducted a feasibility study which has been regulated since 2014. Based on these problems, this study aims to conduct a feasibility study on a new building. Aspects contained in Permenkes No. 75 of 2014 namely aspects of location, buildings, facilities and infrastructure, health equipment, personnel, and organization. There is a health center design stage which is made in accordance with the criteria of the Minister of Health No. 75 of 2014. Based on the results of research conducted on the new building of Public Health Center X, it is known that the location aspect meets 87.5% of the location criteria, the building aspect meets 100% of the building suitability, the facilities and infrastructure aspect meets 100% of the eligibility criteria, the equipment aspect only meets 34% of the equipment that must be owned, the manpower aspect fulfills 73% of the total workforce owned, and the organizational aspect meets 100% of the conformity of the organizational structure, so that overall Public Health Center X has a feasibility percentage of 82.4%. Public Health Center X needs to evaluate and improve. Improvements were made to the location aspect, namely, parking facilities by increasing the capacity of the parking lot. Then do the procurement and purchase of medical equipment because there are still 66% of equipment that is lacking, as well as adding health workers to the positions of public health workers, environmental health workers, and workers.
Determination of GTN Model Parameters Based on Artificial Neutral Network for a Ductile Failure
Authors: CHAHBOUB YASSINE , Szabolcs SZAVAI
Published: September 2021

The Gurson – Tvergaard – Needleman (GTN) mechanical model is widely used to predict the failure of materials based on laboratory specimens, direct identification of Gurson – Tvergaard – Needleman parameters is not easy and time-consuming, and the most used method to determine them is the combination between the experimental results and those of the finite elements, the process consists of repeating the simulations several times until the simulation data matches the experimental data obtained at the specimen level.This article aims to find GTN parameters for the Compact Tension (CT) and Single Edge Tensile Test (SENT) specimen based on the Notch Specimen (NT) using the Artificial Neural Network (ANN) approach. . This work presents how the ANN could help us determine the parameters of GTN in a very short period of time. The results obtained show that ANN is an excellent tool for determining GTN parameters.
FUNGSI TEMBANG SINOM LOGONDHANG LARAS PELOG PATHET BARANG DALAM KARYA TARI PRAWESTRI
Authors: Pamenang Nandhang Wisnu
Published: September 2021

Fungsi tembang sebenarnya adalah memaknai berbagai macam tembang yang terdapat dalam macapat. Macapat terdiri dari sebelas jenis dan memiliki arti sendiri-sendiri. Tembang macapat awalnya adalah berdiri sendiri atau vocal tunggal tetapi dalam perkembanganya disesuaikan dengan gamelan akhirnya menemukan bentuk pengembangan tembag macapat yang lebih menarik. Salah satu perkembangannya adalah dengan digunakannya salah satu jenis tembang macapat sebagai salah satu urutan gending tari yang memunculkan tema dan dinamika musik. Sebagai contoh tembang Sinom Logondhang yang digunakan dalam karya tari Pawestri sebagai awalan dan syairnya berisikan tema tarian. Peranan tembang Sinom Logondhang dalam karya tari Pawestri sangat penting karena sebagai penyampai isi. Kata Kunci : Fungsi, Tembang, Sinom
EXPLORING ATTITUDINAL VARIABLES PREDICTIVE OF HOW MEN PERCEIVE RAPE
Authors: Edwards Sarah R. , Hinsz Verlin B.
Published: September 2021

86 male university students completed an assessment battery regarding their attitudes towards women and beliefs about sexual violence, as well as their own intentions to be sexually violent. They read five vignettes depicting different situations in which women were raped, and answered questions about what they thought happened in the vignettes, i.e. whether the actions depicted were rape. Results showed only one of the constructs, acceptance of sexual violence, predicted men’s ability to recognize rape scenarios, whereas hostility towards women, adversarial sexual beliefs, rape myth acceptance and sex role stereotyping were not significant after acceptance of sexual violence was accounted for. Furthermore, men’s acceptance of sexual violence mediated the relationship of their perceptions of rape vignettes and their self-reported intentions to be sexually violent. Implications for further research in sexual violence and interventions to prevent acts of aggression towards women are discussed.
Key words: rape, sexual aggression, violence against women.
CHILDREN´S ANXIETY AND PARENTING STYLES IN FAMILY IN EIGHT-YEAR-OLDS
Authors: Poledňová Ivana
Published: September 2021

Anxiety is a recurrent topic in personality psychology of today. According to Z. Matějček’s (1991) estimation, the issue of anxiety assumes the third place as for the number of clients in children’s counselling service (behind the issue of intellectual capabilities and ADHD) in the Czech Republic. In children where it occurs to a higher degree, it can have a negative impact on their socialisation, achievements, development of self-confidence. The most influential factor in developing an anxious personality appears to be family environment. If the family fails to satisfy the child’s basic needs – feeling of security and confidence – the child’s development can be in jeopardy. The current research is concentrated on how the style of parenting in families (the so-called parenting styles) is related to anxiety in children at a younger school age. The aim of the research is to find out what relationship there is between the individual components of parenting in families (positive – negative component, component of requirements – freedom) and anxiety in eight-year-olds. These relationships were inquired into from mothers’ perspective by means of questionnaire surveys (Children’s Manifest Anxiety Scale and Questionnaire for acquiring the parenting style in family). The data from 407 mothers of eight-year-old children have been analysed. An assumption that anxiety in children of younger school age is significantly influenced by parenting styles in family has been confirmed. The most anxious children appear to be children raised in families with a negative parental emotional involvement towards the child and at the same time with discordant control. They were also some differences in the importance of individual components of parenting by fathers and mothers for anxious orientation of the child identified.
Key words: anxiety, anxious children, parenting styles.
CONSTRUCTION AND PARTIAL VALIDATION OF AN ANIMAL USE INVENTORY
Authors: Templer Donald I. , Bassman Lynette , Szostak Christine , Graces-Bacsal Rhoda Myra , Arikawa Hiroko , Petrovich Anne
Published: September 2021

A 78-item Animal Use Inventory was constructed. Previous animal attitude scales have centered on affection, bonding, companion animal ownership, animal-human continuity, and general attitudes toward animals, but not use of animals. The present inventory has six scales: Sports and Entertainment, Hunting, Working and Service, Research, Fur, and Loving and Affection. Men scored higher on the Hunting, Research, Entertainment, and Service scales. National Rifle Association members scored higher than animal protection society members on the Hunting and Fur scales. In general, the scales correlated positively with each other but negatively with the Loving and Affection scale. Nevertheless, caution was urged because of the unimpressive Cronbach’s alphas on some of the scales. Further development is recommended.
Key words: animal use, ethnicity, gender, scales, hunting, companionship, work, food.
CHILDHOOD EXPERIENCES OF RECIDIVISTS AS PREDICATORS OF CRIMINOGENIC LIFESTYLE
Authors: Urbanek Arkadiusz
Published: September 2021

The research tackles the issue of the reconstruction of childhood experiences of recidivists. The aim of these reflections is to search for cause and effect relation between socialisation experiences and further criminogenic lifestyle. It is an interdisciplinary work due to the fact that the issue of socialisation, transmission of behaviour patterns and environmental influences reflect scientific domains of psychology, criminology and resocialisation pedagogy. Accomplishing the objective to reconstruct experiences and their relation with subsequent deviant activities a source material from auto-anamnestic interviews was applied. During the research 100 respondents aged 22 to 30 were interviewed. Each of them has already been sentenced repeatedly for criminal offences, serving the punishment of deprivation of liberty. The research was conducted in 2013. In terms of methodology the data analysis concentrated on the qualitative model of structural and reconstruction research, whereas the results were presented within cause-effect matrixes. The construction of each matrix was designed to classify and present common areas of experiences that occurred within biographies of the individual respondents. Therefore, the research, despite its qualitative nature, categorised the socialisation experiences and the predicators of criminogenic lifestyle subject to subgroup classification. The procedure of analysis was dual, i.e. the cause matrixes of 33 random cases were firstly designed, and then applied to replicate the experiences of the rest of the respondents from the group. It allowed not only to distinguish similar experiences but also consolidated the matrixes as tools for further interpretation. The results of research of socialisation experiences and predicators of criminogenic lifestyle are applicable for penitentiary resocialisation practice and psychological support for the prisoners. Moreover, the research results revealed crucial areas of disturbances, such as isolation from the relatives, void of emotional contacts, susceptibility to deviant group influences, or reducing the hierarchy of values to the desires of possession, unfulfilled in their childhood. Key words: childhood, parents – children, pathogenic factors, relations, socialization.
IMPACT OF PERSONAL ORIENTATIONS ON ATTITUDES TO DIVERSITY AND CIVIC SOCIAL-POLITICAL ACTIVENESS
Authors: Zografova Yolanda
Published: September 2021

The dynamically ongoing processes of integration are among the crucial premises for the development of contemporary interpersonal, intergroup and cross-cultural relations, attitudes, conflicts and more. The research problem here directs to an analysis, based on ESS data collected in 8 countries, rounds 2006 and 2008, on the extent to which Europeans' personal orientations significantly influence the attitudes towards ethno-national diversity, in this case, towards two social groups: immigrants coming from poorer countries outside Europe and people with different sexual orientation. Furthermore, the influence of the same factors on the civic activeness and involvement in the social-political processes has been followed. Through regressive analysis the important effect of the co-otherness orientation (a concept developed by Sicakkan, 2003), the orientation to success and traditionalism on all included dependent variables has been proved. The expectations for predicting effects of the three personal orientations have been confirmed regarding the civic involvement and tolerance to diversity. Simultaneously the necessity of working EU politics to deal with the risks of emerging negative attitudes has been pointed out in relation to the broad immigrant and refugee wave to European countries.
Key words: attitudes towards immigrants, civic activeness, co-otherness.
Guardian For Children Out of Marriage in Marriage (Analysis of Syafi'īyyah Fiqh and Civil law)
Authors: Faisal  , Nasrullah  , Muhammad Wali al-Khalizi
Published: September 2021

This writing aims to explain the position guardian in marriage according to Fiqh Syafi'īyyah dan Civil Law, as well asto describe guardian for children out of wedlock according to analysis Fiqh Syafi'īyyah and Civil Law.This research includes library research (Library Research). The method used is descriptive analysis research method, the approach used is a normative approach. To assist the preparation of this research the author reads books and books related to the problems to be discussed. The results showed thatposition guardian in marriage according to Fiqh Syafi'īyyah dan Civil law is very important, meaning that at the same time it has the nature of determining the validity of a marriage contract, so that if a marriage contract is carried out by a guardian or his representative, then the marriage contract will be valid, but on the contrary if the marriage contract is not carried out by the guardian or his representative, then The marriage contract is invalid and invalid. So betweenFiqh Syafi'īyyahand Civil Law has the same view regarding position guardian in marriage. The results also show that which become guardian for children out of wedlock according to Fiqh analysis Shafi'īyyah is guardian judge, in this case is the president even though she is a woman, and state officials whose powers are delegated by the president in matters of trustees such as the Minister of Religion and his lowest officials such as the KUA. Whereas according to Civil Law analysis is the biological father of the child provided there is an acknowledgment from the mother and father and is proven by an authentic deed and can be proven based on science and technology.
Economic benefits of resilient pastures
Authors: Journeaux Phil
Published: September 2021

An improvement in the resilience of New Zealand pastures will have significant economic benefits to the country. The renewal of pastures on-farm is an important aspect of this resilience, which involves a range of costs and benefits. This paper illustrates three aspects of these costs and benefits:(i) That the cost of growing pasture can be substantial, with a combination of direct and indirect costs;(ii) Modelling of an increase in re-grassing level on a representative dairy farm, from 8% to 15% per year, showed a significant Net Present Value and Internal Rate of Return; and(iii) The increase in costs and benefits on-farm, also show a significant multiplier effect on the wider regional economy.
Mastopathy in clinical examples: so similar and so different
Authors: Khuraseva A. B.
Published: September 2021

Aim of study. Using specific clinical examples to analyze the therapeutic and diagnostic approaches in patients with dyshormonal breast diseases (DBD).

Material and methods. Based on the data of the anamnesis, clinical and laboratory examination (ultrasound of the mammary glands and thyroid gland, the results of hormonal examination, MRI of the brain and pituitary gland with contrast enhancement), as well as data from the literature, two clinical cases of DBD were analyzed in detail.

Results. The presented clinical data indicate that hyperprolactinemia is the main marker of hormonal distress in patients with DBD, and MRI of the brain reveals structural changes that lead to an increase in prolactin levels. With moderate hyperprolactinemia, the administration of herbal dopaminomimetics leads to a decrease in the symptoms of DBD and allows to correct the concomitant hormonal pathology.

Conclusions. It is advisable to include MRI of the brain in the scope of examination of patients with DBD, as well as to apply a differentiated approach to the management of patients. One can start therapy with herbal preparations that have a complex positive effect on the female reproductive system, Mastodynon® or Cyclodynon®.
Prognostic value of levels of specific autoantibodies in patients of reproductive age with endometrial polyps
Authors: Tkachenko L. V. , Sviridova N. I. , Gritsenko I. A. , Maksimov S. N.
Published: September 2021

The problem of endometrial polyps in women of reproductive age is one of the urgent problems of modern gynecology. The detection rate of PE according to the data of domestic and foreign scientists reaches 25–35%, and therefore they occupy a leading place in the structure of intrauterine pathology.

The aim. To study the levels of specific autoantibodies (to double-stranded DNA; to TrM‑03 antigens and collagen) and to assess their prognostic value for the risk of PE formation and recurrence in patients of reproductive age.

Materials and methods. Examination of 86 patients aged 18 to 45 years (average age was 34.1 ± 6.3 years), admitted for hysteroscopy, hysteroresection of PE. Study of the relative content of specific autoantibodies to double-stranded DNA; to TrM‑03 antigens and collagen in blood serum was carried out by the method of enzyme-linked immunosorbent assay using specialized reagent kits (ELI-P-Complex).

Results. In the course of this study, it was found that in the overwhelming majority of cases (65.1%) PEs were manifested by various types of AMC. All patients with PE were diagnosed with a significant decrease in the level of autoantibodies to double-stranded DNA, which is a marker of apoptosis processes, as well as a statistically significant decrease in the levels of autoantibodies to platelet antigens TrM‑03. The profile of deviations in the level of autoantibodies to TrM‑03 from the reference range in the area of negative values correlated with an increase in the average level of autoantibodies to collagen.

Conclusions. Determination of the levels of auto-ATs to double-stranded DNA in serum can be used as a marker for predicting the recurrent course of PE. Determination of the levels of auto-ATs to platelet antigens TrM‑03 and to collagen in blood serum can be used as markers for the development of AMC by the type of BMC or a combination of BMC and BMC in patients with endometrial polyps.
Cognitive disorders in perimenopausal women
Authors: Tkachenko L. V. , Kurushina O. V. , Vorobyova Yu. S.
Published: September 2021

The article is devoted to the discussion of possible mechanisms of the development of cognitive disorders, the onset and progression of neurodegenerative diseases and the level of sex hormones in women during perimenopause, a condition associated with endocrine changes caused by a decrease in the follicular mass of the ovaries, and, as a consequence, a decrease in the level of their steroid hormones (in particular, estrogen). It is known that estrogen has a neuroprotective effect, affects the mental and cognitive spheres. Reducing it in the perimenopausal period contributes to the appearance of vegetative symptoms (hot flashes, insomnia, mood changes, etc.), increases the risk of developing depressive-anxiety symptoms, cognitive disorders. In order to correct them and prevent the development of neurodegenerative diseases, it is possible to use hormone replacement therapy to prolong the neuroprotective effect of estrogens in a woman’s body.
Search for light dark matter in the NA64 experiment
Authors: Gninenko S N , Krasnikov N V , Matveev V A
Published: September 2021

We review the most important models of light dark matter and discuss the NA64 experiment aimed at searching for hypothetical particles, including dark matter, in the mass range ⩽ O (1) GeV with the use of electron and muon beams at the Super Proton Synchrotron (SPS) accelerator at CERN. We consider the methods and results of searches in the NA64 and other accelerator experiments and also discuss their further prospects.
On Packing Thirteen Points in an Equilateral Triangle
Authors: Tedeschi Natalie
Published: September 2021

The conversation of how to maximize the minimum distance between points - or, equivalently, pack congruent circles- in an equilateral triangle began by Oler in the 1960s. In a 1993 paper, Melissen proved the optimal placements of 4 through 12 points in an equilateral triangle using only partitions and direct applications of Dirichlet’s pigeon-hole principle. In the same paper, he proposed his conjectured optimal arrangements for 13, 14, 17, and 19 points in an equilateral triangle. In 1997, Payan proved Melissen’s conjecture for the arrangement of fourteen points; and, in September 2020, Joos proved Melissen’s conjecture for the optimal arrangement of thirteen points. These proofs completed the optimal arrangements of up to and including fifteen points in an equilateral triangle. Unlike Melissen’s proofs, however, Joos’s proof for the optimal arrangement of thirteen points in an equilateral triangle requires continuous functions and calculus. I propose that it is possible to continue Melissen’s line of reasoning, and complete an entirely discrete proof of Joos’s Theorem for the optimal arrangement of thirteen points in an equilateral triangle. In this paper, we make progress towards such a proof. We prove discretely that if either of two points is fixed, Joos’s Theorem optimally places the remaining twelve. KEYWORDS: optimization; packing; equilateral triangle; distance; circles; points; thirteen; maximize
An Error Analysis of Orthographic Representation in Written Chinese Characters
Authors: Kuan Wee-Ling
Published: September 2021

This paper reports an error analysis of orthographic representation in written Chinese characters among Mandarin as foreign language (MFL) learners studying at an elementary level at a Malaysian public university in their dictation assessment. A total of 262 stroke error types of their orthographic representation in written Chinese characters were collected and analysed. The errors were consequently classified into four main categories among 165 MFL learners who took part in the study. The study found that participants made most mistakes in the stroke numbers and shape of orthographic representation in written Chinese characters. It was also found that there were detectable mistakes in stroke relation and stroke direction of orthographic representation in written Chinese characters. The cognitive factors contributing to the orthographic representation error types in written Chinese characters are discussed. It is concluded that beginner MFL learners would have a greater tendency to commit several character errors in writing Mandarin because of their low level of orthographic awareness and presumably a high cognitive load given to them as they transit from writing alphabets scripts to writing Chinese characters. Future research could examine how MFL learners cognitively adapt when transitioning from alphabet scripts to Chinese characters. Findings would guide instructors in the teaching Chinese characters more efficient and subsequently, it would allow them to interpret orthographic representations and write Chinese characters more accurately.
Experiential Learning through Field Trips: Effects on Educational, Social and Personal Development among Linguistics Majors
Authors: Campbell Yvonne Michelle , Gedat Remmy
Published: September 2021

The study explores a group of university students' perceptions towards field trips and the effect on their educational, social, and personal development. Data was collected using questionnaires and it has revealed that participants' overall perception of field trips was positive. Findings showed that participants preferred certain aspects of the field trips, particularly those on gaining new experiences and the opportunity to apply what they have learned. It helped improve their knowledge, interest, confidence, communication skills, social training, and awareness of the world around them. However, the least liked aspects were the pre-and post- activities, group size and time allocation. Future studies may want to examine and compare a more varied sampling of students from various fields and perceptions of different genders.
Perceived Stress and Resilience among Private and Public Undergraduate University Students during Covid-19 Pandemic
Authors: Abai Barbara Ruran , Madihie Amalia
Published: September 2021

This is a quantitative study that examines relationships between perceived stress and resilience among private and public undergraduates university students during the COVID-19 pandemic in Malaysia. In total, 160 undergraduate students had been gathered for this study's purposes. Two questionnaires were utilised in the research; the Perceived stress scale and Connor-Davidson Resilience were distributed among respondents through Google Form. The findings reported that there is a low negative relationship between perceived stress and resilience. Apart from that, the findings reported no significant relationship between perceived stress and genders. There was a significant relationship in perceived stress predicting the level of resilience among public and private undergraduates university students during the COVID-19 pandemic. Undergraduates students had a moderate level of perceived stress thus needing a stress intervention or stress management in facing a stressful situation. Resilience is needed to be implemented in every educational system to help to build resilience among students.
The Psychological States of Beggars in Malaysia: Happiness, Subjective Well-Being, and Gratitude
Authors: L. Gin Lim , Kalaivanan Syasyila , Sehu Mohamad Zhooriyati
Published: September 2021

The economic downturn causes a fluctuation of Malaysian beggars with disrupted psychological states. The research focuses on happiness, subjective well-being, and gratitude among the beggars in Kuala Lumpur and Selangor. Ten beggars participated in an in-depth interview. Their selection was based on a purposive sampling technique. Findings show that with life satisfaction and maintained health conditions, they would be contented. Intolerable circumstances currently made the beggars wishing they could restart an ideal life to restore their subjective well-being. Amidst gratefulness, beggars tend to wake up with an appreciation for every little thing. However, the limited psychological care given has caused the number of beggars to escalate. The number of beggars would dwindle by appraising the public with what they necessitate through an awareness brought by findings from the study.
PLUS – An Academic Mentorship Guide for Undergraduate Studies: A Preliminary Study
Authors: Tan Ping Ping
Published: September 2021

This paper introduces an approach to academic mentorship, named PLUS, that specifically assist students in their academic performance through personalised guidance. Through the guidance of a mentor, PLUS lets mentees evaluate their strength and weakness before setting their target to achieve for each subject. Based on this preliminary study with 23 computer science undergraduate students by measuring their academic performance using the cumulative grade point average (CGPA), students that are not introduced to PLUS tend to perform inconsistently throughout their undergraduate studies compared to those introduced to PLUS. Weaker students (CPGA <2.8) with face-to-face guidance with a mentor using the PLUS approach displayed constant improvement compared to those who did not have any mentor. Regardless of what stage of their undergraduate studies the students are introduced to PLUS, all the students that applied PLUS showed consistent improvement and agreed that the method is valid. PLUS, personalised guidance helps the mentor connect with the mentee better, a good complement to the digital education lacking in human connection. It warrants further investigation beyond this preliminary study.
Exploring Managers’ Perspective on Factors Affecting Generation Y Retention
Authors: Thompson Dideana , Muda Agatha Lamentan
Published: September 2021

The study explores factors behind Generation Y employees' retention from the perspective of managers in a financial services sector. A qualitative method was employed, by interviewing eight managers as informants. The results show ten factors affecting Generation Y employees’ retention are compensation and pay, personal development, job security, job satisfaction, work-life balance, reward and recognition, training, leadership, relationship and communication, and work environment. Seven main challenges to retain Generation Y employees identified are loyalty, their love for a challenging job, communication, strategy, working style, satisfaction, and traits. The study discusses implications and suggestions for organisational level strategies to retain Generation Y employees.
Tingles, Triggers and Therapeutic Sensations: Autonomous Sensory Meridian Response (ASMR) among Young Adults
Authors: Loy Vi-Vivian , Mohamad Fitri Suraya
Published: September 2021

This qualitative study explored the experiences of university students watching Autonomous Sensory Meridian Response (ASMR) videos towards psychological effects and mindfulness. ASMR experiences were shown to phenomenologically overlapped with mindfulness and well-being. This study entailed a phenomenological research method used in determining the nature of human experiences regarding a phenomenon through the descriptions of participants in the study. Snowball sampling method was used whereby locating the additional informants was expanded through the recommendation of others for interview. The Interpretative Phenomenological Analysis (IPA) and Positive Emotion, Engagement, Relationship, Meaning, Accomplishment (PERMA) Model were employed to analyse written interview transcripts. Findings revealed how participants viewed ASMR as applicable to enhance their well-being. ASMR is also seen as a potential benefit for participants to improve mindfulness; Participants also reported a better ability to cope with stress and a notable reduction in perception of cognitive workload. A future inquiry could investigate the effects of ASMR on specific cognitive activities.
Cortex-Like Complex Systems: What Occurs Within?
Authors: Grindrod Peter , Lester Christopher
Published: September 2021

We consider cortex-like complex systems in the form of strongly connected, directednetworks-of-networks. In such a network, there are spiking dynamics at each of the nodes (modelling neurones), together with non-trivial time-lags associated with each of the directed edges (modelling synapses). The connections of the outer network are sparse, while the many inner networks, called modules, are dense. These systems may process various incoming stimulations by producing whole-system dynamical responses. We specifically discuss a generic class of systems with up to 10 billion nodes simulating the human cerebral cortex. It has recently been argued that such a system’s responses to a wide range of stimulations may be classified into a number of latent, internal dynamicalmodes. The modes might be interpreted as focussing and biasing the system’s short-term dynamical system responses to any further stimuli. In this work, we illustrate how latent modes may be shown to be both present and significant within very large-scale simulations for a wide and appropriate class of complex systems. We argue that they may explain the inner experience of the human brain.
Human Three-Dimensional Hepatic Models: Cell Type Variety and Corresponding Applications
Authors: Xu Qianqian
Published: September 2021

Owing to retained hepatic phenotypes and functions, human three-dimensional (3D) hepatic models established with diverse hepatic cell types are thought to recoup the gaps in drug development and disease modeling limited by a conventional two-dimensional (2D) cell culture system and species-specific variability in drug metabolizing enzymes and transporters. Primary human hepatocytes, human hepatic cancer cell lines, and human stem cell–derived hepatocyte-like cells are three main hepatic cell types used in current models and exhibit divergent hepatic phenotypes. Primary human hepatocytes derived from healthy hepatic parenchyma resemble in vivo–like genetic and metabolic profiling. Human hepatic cancer cell lines are unlimitedly reproducible and tumorigenic. Stem cell–derived hepatocyte-like cells derived from patients are promising to retain the donor’s genetic background. It has been suggested in some studies that unique properties of cell types endue them with benefits in different research fields of in vitro 3D modeling paradigm. For instance, the primary human hepatocyte was thought to be the gold standard for hepatotoxicity study, and stem cell–derived hepatocyte-like cells have taken a main role in personalized medicine and regenerative medicine. However, the comprehensive review focuses on the hepatic cell type variety, and corresponding applications in 3D models are sparse. Therefore, this review summarizes the characteristics of different cell types and discusses opportunities of different cell types in drug development, liver disease modeling, and liver transplantation.
Recent Advances and Perspectives on Expanding the Chemical Diversity of Lasso Peptides
Authors: Wang Mengjiao , Fage Christopher D. , He Yile , Mi Jinhui , Yang Yang , Li Fei , An Xiaoping , Fan Huahao , Song Lihua , Zhu Shaozhou , Tong Yigang
Published: September 2021

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing family of natural products that exhibit a range of structures and bioactivities. Initially assembled from the twenty proteinogenic amino acids in a ribosome-dependent manner, RiPPs assume their peculiar bioactive structures through various post-translational modifications. The essential modifications representative of each subfamily of RiPP are performed on a precursor peptide by the so-called processing enzymes; however, various tailoring enzymes can also embellish the precursor peptide or processed peptide with additional functional groups. Lasso peptides are an interesting subfamily of RiPPs characterized by their unique lariat knot-like structure, wherein the C-terminal tail is inserted through a macrolactam ring fused by an isopeptide bond between the N-terminal amino group and an acidic side chain. Until recently, relatively few lasso peptides were found to be tailored with extra functional groups. Nevertheless, the development of new routes to diversify lasso peptides and thus introduce novel or enhanced biological, medicinally relevant, or catalytic properties is appealing. In this review, we highlight several strategies through which lasso peptides have been successfully modified and provide a brief overview of the latest findings on the tailoring of these peptides. We also propose future directions for lasso peptide tailoring as well as potential applications for these peptides in hybrid catalyst design.
Systematic Review of the Application of Perinatal Derivatives in Animal Models on Cutaneous Wound Healing
Authors: Pichlsberger Melanie , Jerman Urška Dragin , Obradović Hristina , Tratnjek Larisa , Macedo Ana Sofia , Mendes Francisca , Fonte Pedro , Hoegler Anja , Sundl Monika , Fuchs Julia , Schoeberlein Andreina , Kreft Mateja Erdani , Mojsilović Slavko , Lang-Olip Ingrid
Published: September 2021

Knowledge of the beneficial effects of perinatal derivatives (PnD) in wound healing goes back to the early 1900s when the human fetal amniotic membrane served as a biological dressing to treat burns and skin ulcerations. Since the twenty-first century, isolated cells from perinatal tissues and their secretomes have gained increasing scientific interest, as they can be obtained non-invasively, have anti-inflammatory, anti-cancer, and anti-fibrotic characteristics, and are immunologically tolerated in vivo. Many studies that apply PnD in pre-clinical cutaneous wound healing models show large variations in the choice of the animal species (e.g., large animals, rodents), the choice of diabetic or non-diabetic animals, the type of injury (full-thickness wounds, burns, radiation-induced wounds, skin flaps), the source and type of PnD (placenta, umbilical cord, fetal membranes, cells, secretomes, tissue extracts), the method of administration (topical application, intradermal/subcutaneous injection, intravenous or intraperitoneal injection, subcutaneous implantation), and the type of delivery systems (e.g., hydrogels, synthetic or natural biomaterials as carriers for transplanted cells, extracts or secretomes). This review provides a comprehensive and integrative overview of the application of PnD in wound healing to assess its efficacy in preclinical animal models. We highlight the advantages and limitations of the most commonly used animal models and evaluate the impact of the type of PnD, the route of administration, and the dose of cells/secretome application in correlation with the wound healing outcome. This review is a collaborative effort from the COST SPRINT Action (CA17116), which broadly aims at approaching consensus for different aspects of PnD research, such as providing inputs for future standards for the preclinical application of PnD in wound healing.
Polymer Scaffolds-Enhanced Bone Regeneration in Osteonecrosis Therapy
Authors: Dong Hengliang , Zhu Tongtong , Zhang Mingran , Wang Dapeng , Wang Xukai , Huang Guanning , Wang Shuaishuai , Zhang Minglei
Published: September 2021

Osteonecrosis without effective early treatment eventually leads to the collapse of the articular surface and causes arthritis. For the early stages of osteonecrosis, core decompression combined with bone grafting, is a procedure worthy of attention and clinical trial. And the study of bone graft substitutes has become a hot topic in the area of osteonecrosis research. In recent years, polymers have received more attention than other materials due to their excellent performance. However, because of the harsh microenvironment in osteonecrosis, pure polymers may not meet the stringent requirements of osteonecrosis research. The combined application of polymers and various other substances makes up for the shortcomings of polymers, and to meet a broad range of requirements for application in osteonecrosis therapy. This review focuses on various applying polymers in osteonecrosis therapy, then discusses the development of biofunctionalized composite polymers based on the polymers combined with different bioactive substances. At the end, we discuss their prospects for translation to clinical practice.
An Open-Source Framework for Automated High-Throughput Cell Biology Experiments
Authors: Katunin Pavel , Zhou Jianbo , Shehata Ola M. , Peden Andrew A. , Cadby Ashley , Nikolaev Anton
Published: September 2021

Modern data analysis methods, such as optimization algorithms or deep learning have been successfully applied to a number of biotechnological and medical questions. For these methods to be efficient, a large number of high-quality and reproducible experiments needs to be conducted, requiring a high degree of automation. Here, we present an open-source hardware and low-cost framework that allows for automatic high-throughput generation of large amounts of cell biology data. Our design consists of an epifluorescent microscope with automated XY stage for moving a multiwell plate containing cells and a perfusion manifold allowing programmed application of up to eight different solutions. Our system is very flexible and can be adapted easily for individual experimental needs. To demonstrate the utility of the system, we have used it to perform high-throughput Ca2+ imaging and large-scale fluorescent labeling experiments.
The Skin Microbiome of Patients With Atopic Dermatitis Normalizes Gradually During Treatment
Authors: Khadka Veda D. , Key Felix M. , Romo-González Carolina , Martínez-Gayosso Adrián , Campos-Cabrera Blanca L. , Gerónimo-Gallegos Armando , Lynn Tucker C. , Durán-McKinster Carola , Coria-Jiménez Rafael , Lieberman Tami D. , García-Romero Maria T.
Published: September 2021

Background

Atopic dermatitis (AD) is characterized by an altered skin microbiome dominantly colonized by S. aureus. Standard treatment includes emollients, anti-inflammatory medications and antiseptics.

Objectives

To characterize changes in the skin microbiome during treatment for AD.

Methods

The skin microbiomes of children with moderate-to-severe AD and healthy children were investigated in a longitudinal prospective study. Patients with AD were randomized to receive either standard treatment with emollients and topical corticosteroids or standard treatment with the addition of dilute bleach baths (DBB) and sampled at four visits over a three-month period. At each visit, severity of AD was measured, swabs were taken from four body sites and the composition of the microbiome at those sites was assessed using 16S rRNA amplification.

Results

We included 14 healthy controls and 28 patients. We found high relative abundances of S. aureus in patients, which correlated with AD severity and reduced apparent alpha diversity. As disease severity improved with treatment, the abundance of S. aureus decreased, gradually becoming more similar to the microbiomes of healthy controls. After treatment, patients who received DBB had a significantly lower abundance of S. aureus than those who received only standard treatment.

Conclusions

There are clear differences in the skin microbiome of healthy controls and AD patients that diminish with treatment. After three months, the addition of DBB to standard treatment had significantly decreased the S. aureus burden, supporting its use as a therapeutic option. Further study in double-blinded trials is needed.
Psychometric Analysis and Coupling of Emotions Between State Bulletins and Twitter in India During COVID-19 Infodemic
Authors: Aggrawal Palash , Jolly Baani Leen Kaur , Gulati Amogh , Sethi Amarjit , Kumaraguru Ponnurangam , Sethi Tavpritesh
Published: September 2021

COVID-19 infodemic has been spreading faster than the pandemic itself. The misinformation riding upon the infodemic wave poses a major threat to people’s health and governance systems. Managing this infodemic not only requires mitigating misinformation but also an early understanding of underlying psychological patterns. In this study, we present a novel epidemic response management strategy. We analyze the psychometric impact and coupling of COVID-19 infodemic with official COVID-19 bulletins at the national and state level in India. We looked at them from the psycholinguistic lens of emotions and quantified the extent and coupling between them. We modified Empath, a deep skipgram-based lexicon builder, for effective capture of health-related emotions. Using this, we analyzed the lead-lag relationships between the time-evolution of these emotions in social media and official bulletins using Granger’s causality. It showed that state bulletins led the social media for some emotions such as Medical Emergency. In contrast, social media led the government bulletins for some topics such as hygiene, government, fun, and leisure. Further insights potentially relevant for policymakers and communicators engaged in mitigating misinformation are also discussed. We also introduce CoronaIndiaDataset, the first social-media-based Indian COVID-19 dataset at the national and state levels with over 5.6 million national and 2.6 million state-level tweets for the first wave of COVID-19 in India and 1.2 million national tweets for the second wave of COVID-19 in India.