bluuebunny/crossref_metadata_2025 huggingface dataset:
The Potential of New Purple Yardlong Bean Varieties in Open-Field Organic Farming Compared with Chemicals Management under Plastic Net-House
Authors:   Department of Plant Science, Textile, and design, Faculty of Agriculture and Technology, Rajamangala University of Technology Surin Campus 56000, Ngamhui Nion , Boonraeng Supot ,   Department of Agro-Industry, Faculty of Agricultural Technology, Chiang Mai Rajabhat University 50300, Phimchan Paongpetch ,   Department of Plant Science, Textile, and design, Faculty of Agriculture and Technology, Rajamangala University of Technology Surin Campus 56000
Published: May 2024

The purple yardlong bean "Muang Rachamongkol" is a pure line variety and was improved under organic farming. To examine this variety potential, a randomized complete block design was planned with 4 replications of 20 plants each, in comparison with two varieties: “Sirindhorn#1” and “Laisua Jakkaparn”. These bean varieties were grown during September-November 2020 under 2 production systems; 1) organic system under open-field and 2) under plastic net-house. The results showed that the characteristics of the new variety such as flower, fruit, and seed characters differed from the comparative varieties. For plant growth including plant height and the number of branches, and the interaction between the production system and varieties during the 3rd-6th weeks after planting were found to be significantly different. Plants grown under a chemical system showed a higher plant height and number of branches than an organic system, and varieties “Muang Rachamongkol” and “Sirindhorn#1” showed the highest plant height in both conditions. In addition, the influence of the production system was observed with the chemical system which showed the high number of pods, total pod yield, and pod weight of 34.91 pod/plant, 815.11 g/plant, and 27.67 g/pod, respectively. “Muang Rachamongkol” showed 27.15 pod/plant, 611.83 g/plant, and 26.41 g/pod, which was similar to the responses of “Sirindhorn#1” for the growth, yield, uniformity score, and plant vigor score in both of organic and chemical conditions.
EXPERIMENTAL STUDY ON MECHANICAL PROPERTIES OF MODIFIED PERVIOUS CONCRETE AS A RIGID PAVEMENT FOR LOW VOLUME TRAFFIC
Authors:   Sanketika Vidya Parishad Engineering College(SVPEC), B Ms..Raghuram
Published: May 2024

The previous concrete which is also known as No-fines concrete is a mixture of cement, water and a particular sized coarse aggregate combined to form a porous structural material. Application of pervious concrete in pavements mainly focuses on storm water control mostly in urban areas where scarcity of land is high. Permeable pavement allows water from precipitation and other sources to pass through it and therefore reduces the runoff from a site, which results in the recharge of ground water and increases the level. In this view it is necessary to study the behavior of pervious concrete by enhancing its mechanical properties by maintaining required permeability. The main objective of this investigation is to develop a strong pervious concrete mix using with waste tyre rubber powder. In addition, it is also aimed to compare the mechanical properties of these modified mixes with pervious concrete. The properties such as compressive strength, indirect tensile strength, flexural strength and permeability tests are performed to determine the suitability. From the study it is concluded that using of fine aggregate and waste tyre rubber powder as partial replacement material in coarse aggregate shows significant improvement in the mechanical properties (i.e. compressive strength, indirect tensile strength and flexural strength) with maintaining required permeability. Among all the considered modified mixes, MPC-4 (i.e. 10% waste tyre rubber powder as partial replacement material in coarse aggregate) performs better.
HARMONISASI PERAYAAN HARI RAYA NYEPI DI DESA ADAT KEROBOKAN MELALUI TRADISI NGAYAH (PERSPEKTIF NILAI PENDIDIKAN AGAMA HINDU)
Authors: Susanti Komang Dewi
Published: May 2024

Perkembangan ilmu pengetahauan dan teknologi memberikan dampak yang signifikan bagi kegiatan keagamaan di Bali khususnya di Desa Adat Kerobokan, Kabupaten Buleleng. Berbagi sarana upacara yang dibutuhkan saat ini sudah dijual dipasar, sehingga generasi muda malas untuk belajar membuat banten, dengan asumsi lebih praktis dan efisien. Upaya yang dilakukan desa adat untuk melestarikan dan melatih generasi muda Hindu tentang cara membuat banten adalah melaksanakan tradisi ngayah sebagai wahana dalam pembelajaran pendidikan Hindu yang mencakup Tattwa, Susila dan Upacara. Jenis penelitian ini adalah penelitian kualitatif dengan pendekatan fenomenologis untuk mengkaji fenomena yang terjadi di Desa Adat Kerobokan dengan harapan mampu berkontribusi dalam meningkatkan sradha bhakti kepada Ida Sang Hyang Widhi Wasa melalui tradisi ngayah yang diselenggarakan menjelang Hari Raya Nyepi untuk menumbuhkan harmonisasi. Melalui tradisi ngayah yang diselenggarakan pada Hari Raya Nyepi mampu meningkatkan sradha bhakti kepada Ida Sang Hyang Widhi Wasa sesuai dengan ajaran panca sradha (filsafat keTuhanan Hindu). Nilai susila tradisi ngayah adalah wahana berinteraksi dan menjaga kebersamaan. Nilai acara tradisi ngayah adalah sebagai wujud bhakti mempersembahkan korban suci tulus iklas yadnya.Kata kunci ; Ngayah, Nyepi, Nilai Pendidikan Agama Hindu
THE PROBLEMS AND SOLUTIONS IN THE ECONOMIC MANAGEMENT OF MODERN STATE -OWNED ENTERPRISES
Authors: Aray Adel'
Published: May 2024

In the new situation of economic globalization, state-owned enterprises face the dual pressures of fierce market competition and social responsibility. This article aims to comprehensively discuss the problems faced by modern state-owned enterprises in economic management and propose appropriate measures to solve them. Firstly, it analyzes the effects of competition pressure, internal mismanagement and social responsibility on the economic management of state-owned enterprises. Secondly, it emphasizes the importance of economic management for the competitiveness and long-term development of enterprises and its key role in the international market. Finally, possible ways to solve the economic management problems of modern state-owned enterprises through system innovation, strengthening internal management and raising awareness of social responsibility are suggested. A case study demonstrates the successful experience of a state-owned enterprise in economic management, which serves as a useful inspiration for other state-owned enterprises.
PROSPECTS FOR THE INTRODUCTION AND USE OF DIGITAL CURRENCIES BY CENTRAL BANKS
Authors: Kondrashov Grigoriy
Published: May 2024

The global economy is constantly changing. The spread of "digital" technologies sooner or later had to affect the evolution of money. If the emergence of cryptocurrencies is considered as an attempt by individuals and companies to get away from state payment systems, then digital currencies of central banks or Central securities are an asymmetric response of the state to the development of cryptocurrencies. The purpose of the study is to identify trends in the introduction and use of digital currencies by central banks. The object of research: digital currencies. Subject of research: digital currencies of central banks. Methodology: Using the method of systematic analysis of scientific sources and regulatory documents regulating the scope of digital currencies, the trends of digital currencies and the transformation of the payment system, which are relevant today, were investigated.
Result: It should be noted that the synchronous decision of almost all Central Banks in the world to accelerate the introduction of central securities for domestic and international settlements confirms the approach according to which, when analyzing relations between countries, more attention should be paid to real economic ties and processes, rather than declared statements.
ISSUES OF DEVELOPMENT OF THE KAZAKH LANGUAGE TRAINING CORPUS
Authors: Zhanabekova A. A. , Zholshayeva M. S. , Mukatayeva A. Zh. , Tlegenova G. B.
Published: May 2024

The creation of national corpora is an urgent problem of the modern digital era. The creation of corpora in the world linguistics began in the middle of the last century. The experience of creating a corpus of the first English language served as a basis for creating corpora of other European languages, as well as Russian and Turkic languages. Research and teaching corpora, which were previously carried out manually, have achieved great results through the use of. The corpora provided the user with more materials, created new dictionaries and facilitated linguistic research. The number of corpus users increased day by day. Such needs favored the creation of corpora depending on the purpose of the user. For historians or researchers of historical linguistics – historical corpus, for translators and language learners – parallel corpus, for researchers of speech peculiarities and development of speech culture - there was a need to create oral corpora. At the same time, there is an urgent need to create educational corpuses – the only tool for digitalization of education. An educational corpus is an information and corpus base for language learners. The article gives an overview of the world experience in the development of educational corpora. The questions of what texts are contained in the text base of English, Russian language learning corpora, what linguistic information is provided to linguists, etc. are studied. The necessary prerequisites for thedevelopment of the Kazakh language training course being developed at the A. Baitursynov Institute of Linguistics will also be determined. Metadata and linguistic markups aimed at teaching/learning the language, ways of adapting reference tools to Kazakh language acquisition by language learners, computer-software methods are considered.
LANGUAGE CONCEPTS «DAY» AND «NIGHT» IN THE POETIC WORLD OF F.I. TYUTCHEV (THE EXPERIENCE OF CORPUS RESEARCH)
Authors: Begaliyeva S. , Shmakova E. , Ryssaldiyev Zh. , Aliakhunova R.
Published: May 2024

The present study is devoted to the interpretation of linguistic concepts “Day” and “Night” in the artistic texts of the classic of Russian poetry F.I. Tyutchev. The research is carried out in an interdisciplinary aspect based on the linguistic understanding of the concept and the interpretation of this concept in the literary study of the poetic text. In addition, the research uses corpus linguistics methods and corpus technologies for the analysis of a work of art. The relevance of the topic selection is due to the increasing interest of scientists in corpus studies of literary text. The research has a scientific novelty, which is justified by the insufficient development of algorithms for corpus research of poetic text, especially in terms of identifying concepts and their interpretation. The paper comprehensively reveals the theoretical foundations of the study of concepts in various aspects: linguistic, literary, corpus. The works of Kazakhstani scientists on the concepts on the basis of which the theoretical basis of the study is being built are reflected. The structure of the concept, its types and relationship with the author's idea are revealed. In the practical part, the interpretation of the concepts “Day” and “Night” in the lyrics of F.I. Tyutchev is presented, a corpus study is conducted to identify the frequency of use of a particular concept, the relationship of the concept with the thematic focus of the poem and its ideological content, interesting observations and conclusions are made. In addition to the theoretical substantiation of the problem of interpretation of artistic concepts in a poetic text, the paper presents an algorithm for the study of the concepts “Day” and “Night” in F.I. Tyutchev's poems, based on work with the RNC (Russian National Corpus).
KAZAKH DIGITAL TERMINOLOGY: EXPERIENCE IN DEVELOPING A TERMINOLOGICAL SUBCORPUS (metatext and terminology markup parameters)
Authors: Kulmanov S. K. , Bissengali A. Z. , Shulenbayev N. K. , Omarova A. D.
Published: May 2024

The article is devoted to scientific-theoretical and applied-practical issues (development of metatext and terminological markings) of the creation of a terminological subcorpus, which is part of the National Corpus of the Kazakh Language (NCKL).

In the course of the study, the following results were achieved in the development of the terminological subcorpus of the NCKL: 1) scientific texts included in the terminological corpus base have the following meta-text markups: Source, Text type, Text Title, Text Style, Keywords of the text, Field of science, Text language, Number of pages of text, Text graphics, Number of usages, Age of the audience, Subcorpus, Date the text was entered, Markup; 2) terminological terms of various branches of science were assigned terminological markings, including the following parameters: variants of the term in Kazakh and Russian, the etymology of the term and the words that make up the terminological combination, and its equivalent in the Kazakh language, the definition of each term in the Kazakh language, the source from which it was obtained definition of the term, area(s) of application of the term, author of the term, composition of the term, approved version of the term, year of its approval, translation of the term in industry terminology dictionaries, use of the term in legislation (translation and variants).

The theoretical significance: clarifies and complements the scientific foundations of the compilation of bilingual and multilingual industry, explanatory terminological dictionaries, the development of electronic dictionaries, contributes to the development of applied terminology and terminography.

The practical significance: it can be used in lexicographic practice in the process of developing thematic and sectoral terminological subcorps and during the improvement of the structure and content of various terminological dictionaries.

The research used methods of collection, sorting, systematization, translation, diachronic, factual, lexicographic comparison and matching, structural (morphological, syntactic) analysis.
PHRASEOLOGICAL UNITS IN A WRITTEN MONUMENT SAFE SHEDS «GULISTAN BIT-TURKI»
Authors: Seitbekova A. A. , Mamyrbek G. M.
Published: May 2024

The language of written monuments of the Golden Horde era is rich in such artistic and stylistic means  as phraseological units and metaphors that reflect the worldview and way of life of the Turkic peoples. Therefore, the  relevance of the research topic is due to the value of studying phraseological units and metaphors found in the written  monument of the Sarai Safe «Gulistan bit-Turki» (hereinafter – «Turkshe Gulistan») of the Golden Horde period. The article  analyzes phraseological units and metaphors in two aspects: structural-semantic and linguocognitive. Phraseological units  and metaphors are divided into four lexical and semantic groups and their continuity with the Kazakh language is analyzed.  Phraseological units and figurative expressions, collected in eight sections of the written monument, form the concept of  «Man», which reflect the existence and knowledge of the people. They are intertwined with the religious knowledge of that  period. The concept of «Man» is subdivided and analyzed according to the linguocognitive models «Man – power», «Man – satisfaction», «Man – about the benefits of laconicism».

 The practical significance of the work. Linguistic explanations of metaphors and phraseological units in the text of  "Turkshe Gulistan" can be used in the practical development of semantic meta-marks of linguistic units of medieval texts of  the historical subcorpus. They are being developed within the framework of the National Corpus of the Kazakh Language at  the Institute of Linguistics Akhmet Baitursynov.
THE HISTORY OF THE DEVELOPMENT AND FORMATION OF ADVERBIAL SUFFIXES -YP, -IP (based on the monuments of Mamluk Kipchak)
Authors: Sadykbekov K.
Published: May 2024

There has been no in-depth, comprehensive and systematic study of the history of one of the complex grammatical categories of verbs-the category of adverbs, although it is found only slightly in some monuments and textbooks concerning the history of a particular language. One of the urgent problems of Kazakh Turkological science is a comprehensive study of the Turkic languages of any linguistic unity in historical periods, a comprehensive study of them from a synchronous and diachronic point of view and determining the level of historical continuity in comparison with our modern language.

The article examines the grammatical function of the adverbial suffixes -yp, -ip, -up, -üp, -p in the Mamluk-Kipchak language, their influence and phonetic variants on the meaning of the word to which it is attached, the history of development and formation. The research is based on the materials of 5 monuments written in the Mamluk-Kipchak language and extant to the present day. The research work is based on the main method of studying the historical development of language - the comparative historical method.

Phonetic variants of adverbial forms with suffixes -yp, -ip, -up, -üp, -p the order of attachment to the root, various semantic gradients in the main and indirect meanings, all of them do not differ much from modern Turkic languages, including Kazakh. Some features have been preserved in the modern Oguz language, and some in Kipchak. Even small differences between them can be considered as a natural phenomenon that arises during the historical development of the language.
ABOUT THE UNIFICATION PROBLEM GRAMMATICAL TERMS IN THE KAZAKH AND TURKISH LANGUAGES
Authors: Kassymova A. A. , Khabiyeva A. A. , Omarbayeva G. S.
Published: May 2024

In the context of the modern process of globalization, the intensification of scientific, technical, economic, political, cultural, literary, and linguistic ties between states indicates that an increasing number of new words have entered the language and have become an urgent problem of the system of formation of new words in terminology. In order to determine the manifestation of the modern system of terminology formation in the Turkic languages, a comparative study was conducted on the example of grammatical terms of the Kazakh and Turkish languages, similarities and differences in the grammar of the two languages were revealed, prerequisites for the possibility of unification of grammatical terms formed at the stage of global development were created. To achieve this goal, the article characterizes the stages of the formation of the grammatical sphere in the Kazakh and Turkish languages, reviews scientific conclusions in the field of grammar of two languages and the works of the founding scientists of linguistics. In the course of the study, terms from grammar textbooks in two languages were generalized, their structural specificity, terminological sphere, from which language they entered in the presence of a borrowed term were analyzed. Similarities and differences in the sound, root form of grammatical terms grouped from two languages were presented in the comparative table. According to the results of the study, it was found that the grammatical terms of the Kazakh language have been finally formed, and in the Turkish language grammatical terms still have a variety. The results of the research of the article acquire great practical importance in the unification of grammatical terms in grammar textbooks used in teaching Kazakh and Turkish.
Defining Domestic Violence and Women's Autonomy in Law
Authors: Solanki Gopika
Published: May 2024

This paper explores the complex relationship between Indian feminism and the law and legal systems, as reflected in the recent (2015) Bombay High Court judgment on domestic violence. It is divided into two sections. The first section looks at feminist interventions in marital disputes and domestic violence through grassroots efforts, and outlines the multidimensional and hybrid feminist understandings of domestic violence, discusses change strategies and ethical principles that underpinned their action, and addresses the enactment of the Protection of Women from Domestic Violence Act, 2005 (PWDVA) as one such strategy against domestic violence. This section also focuses on feminist dilemmas and foregrounds the issue of women’s autonomy in situations of domestic violence. The mainstreaming of feminist legal interventions through the PWDVA has brought new challenges for feminists and the second section discusses this issue by focusing on judicial intervention in deciding the boundary of counselling and mediation practices by protection officers under the PWDVA. We suggest that as seen in the 2015 judgement, while the judiciary has upheld some aspects of feminist practice and disallowed reconciliation in situations of serious physical domestic violence, its over-emphasis on equating physical violence with domestic violence and its protectionist stance has limited women’s autonomy and gone against feminist counselling principles and politics undergirding feminist interventions in situations of domestic violence. We suggest that this judgment can be read as a dialogue within a section of feminist groups in India who endorse feminist political ideals of liberty, individual rights, and equality and seek to institutionalize these within the law. This paper is an analytical and interpretive piece and not an empirical inquiry into legal practice or a survey of case law developments of the PWDVA. It focuses on normative questions of theoretical and policy relevance arising from feminist engagements with law.
Advancements in Oncology: Evolving Standards of Care and Personalized Treatment in Lung Cancer
Authors:   Major of Medicine, Universitas Prima Indonesia, Medan, Indonesia, Weiqing Pu
Published: May 2024

Lung cancer remains a significant global health concern, impacting patients and healthcare systems alike. In recent years, substantial progress has been made in understanding the biology, diagnosis, and treatment of both small-cell and non-small-cell lung cancer (SCLC and NSCLC). This research paper synthesizes and reviews key findings from multiple studies published between 2007 and 2023, addressing various aspects of lung cancer researchThe studies covered in this review encompass a broad spectrum of topics, including systemic therapy, targeted treatments, genetic mutations, healthcare strategies, and patient outcomes. Notable highlights include the impact of EGFR tyrosine kinase inhibitors on NSCLC treatment, the role of nuclear factor erythroid 2-related factor 2 (NRF2) in lung adenocarcinoma, the utilization of large databases in radiation oncology research, and the importance of empathy in patient care.The paper also examines the latest developments in the molecular epidemiology of lung cancer, differences in lung cancer susceptibility among ethnic populations, and the implementation of multidisciplinary clinics for timely lung cancer care. It further delves into the significance of liquid biopsy in identifying genetic mutations for targeted therapies, the effect of ALK-positive cell percentage on the outcomes of Alectinib treatment, and the role of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors in adjuvant therapy.Furthermore, this review assesses the impact of platinum-based chemotherapy on the survival of NSCLC patients and explores predictive factors, such as the VeriStrat test, in second-line therapy. The research also addresses the challenges and opportunities in the use of immune checkpoint inhibitors in advanced NSCLC, as well as the clinical utility of epidermal growth factor receptor (EGFR) testing in first-line therapy.In conclusion, this comprehensive review sheds light on the current state of lung cancer research, highlighting breakthroughs, challenges, and the potential for future advancements in the diagnosis and treatment of this life-threatening disease. The insights gathered from these diverse studies provide a valuable resource for clinicians, researchers, and healthcare providers in their efforts to combat lung cancer and improve patient outcomes.
A short clinical perspective on the disease amyotrophic lateral sclerosis
Authors:   Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China, Kasirajan Gayathri
Published: May 2024

There are sporadic and inherited variants of the motor neuron disease amyotrophic lateral sclerosis (ALS). Young and middle-aged persons are more likely to get ALS, and there aren't many therapies for it. Even though frontotemporal dementia mostly affects the nervous system and the fact that cognitive and behavioral symptoms have been documented for more than a decade, there are signs that ALS and frontotemporal degeneration coincide medically, radiologically, and pathologically, in addition to genetically. Cognitive decline in ALS is characterized by personality changes, irritability, obsessions, a lack of comprehension, and extensive abnormalities in frontal executive functions. The alterations in personality, social behavior, and executive function seen in frontotemporal dementia are consistent with this presentation. We also provide guidelines for the clinical assessment of frontotemporal dysfunction in patients with ALS. Improved protection for victims and their households as well as useful insights into the biology of neurodegeneration will result from knowledge of cognitive damage in ALS.
Exploring the potential of Beta Vulgaris L. Against thrombocytopenia: in vitro, in silico, phytochemicals, and antioxidant analysis
Authors:   Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia, Nugraha Sony Eka
Published: May 2024

The purpose of this study was to assess anti- thrombocytopenia of beetroot extract using both in vitro and in silico methods. Additionally, antioxidant capacity, phenolic content, and flavonoid content of beetroot were determined. The extraction procedure was optimized by reflux method, the extracts obtained were examined to determine the Total Phenolic Content (TPC) and Total Flavonoid Content (TFC) using the Folin-Ciocalteu colorimetric and aluminum chloride methods, respectively. Furthermore, antioxidant capacity was assessed using the DPPH method, while betanin concentration was determined by thin-layer chromatography. This research approach encompasses the binding acticity of ligands and target proteins, the process of docking thrombopoietin receptor (TPOr) and betanin compound using Swissdock, and the examination of docking data using the USCF Chimera software. The studies revealed that the reflux-extracted beetroot extract had a total phenol concentration of 39.72 ± 2.56 mgGAE/g. The flavonoid concentration of beetroot extract obtained using reflux extraction was 5.47 ± 0.39 mg QE/g. The qualitative test conducted using thin layer chromatography yielded data indicating that the reflux-extracted extract tested positive for betanin. The reflux approach yielded an extract with antioxidant activity (IC50) of 95.71 μg/ml. The results of the molecular docking simulation showed that the betanin compound had a ΔG value of -8.1 Kcal/mol. It interacts with multiple amino acid residues, including LEU62, PRO63, ALA64, VAL65, ASP66, ARG138, THR139, THR140, ALA141, HIS142, ALA147, ILE148, LEU150, SER151, HIS154, PRO70, ARG71, ARG102, PHE104, PHE105, PRO106, and PHE126. An in vitro study demonstrated that the extract of Beta vulgaris L. has the ability to induce blood coagulation, indicating its potential as a haemostatic agent. Additionally, in silico investigations suggest that the betanin chemicals found in beetroot serve as TpoR agonists, and it can be concluded that betanin has antithrombocytopenia potential.
Development and evaluation of therapeutically useful oral solid tablets containing natural extracts: a quality by design approach
Authors:   Zydus Wellness Institute, Zydus Wellness Research & Development, Ahmedabad, Gujarat, India, Vyas Tejas
Published: May 2024

The quality target product profile was created for therapeutically useful oral solid tablets containing natural extracts. Important quality criteria were recognised. The risk priority no. was used to evaluate critical materials for initial risk assessment. Using Central Composite Design, the effects of critical parameters (croscarmellose sodium & PVP K-30) were investigated. The impact of the formulation variables X1: Croscarmellose sodium and X2: PVP K-30 on responses Y1: DT (Disintegration time in minutes) and Y2: Friability (%) were assessed. Factor X2: PVP K-30 was found to have a substantial impact on both the responses. The optimized formulation having Croscarmellose sodium-20mg/tab and PVP K-30 8 mg/tab meets the QTPP (quality target product profile) and essential requirements for oral solid tablets standards. Present research shows that QbD (quality by design) is an excellent method which comprehending the critical parameters for optimising therapeutically useful oral solid tablets containing natural extracts.
In-silico design and synthesis of curcumin derivatives with enhanced antibacterial and anti-inflammatory activities
Authors:   Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharastra, India, Sabale Prafulla M
Published: May 2024

Since curcumin and curcuminoids include potential functional groups (such as α, β-unsaturated β-diketone, α, β-unsaturated ketone, and β 0-hydroxy-α, β-unsaturated ketone linked with aromatic rings on both sides), they have been the subject of much discussion. These groups have anti-inflammatory, anti-cancer, and antioxidant qualities, among other bioactivities. Using spectroscopic techniques, novel compounds of curcumin were created and described. This study assessed the antibacterial and anti-inflammatory properties of PDB ID:1IU 4 and PDB ID: 4LHF molecular docking, utilizing in silico models. In terms of binding affinity, compounds C-04 and C-05 they had a greater affinity for the 1IU4 and 4LHF, respectively. Using the Agar disc diffusion plate method (500μg/mL), the derivatized compounds were evaluated for their in-vitro antibacterial properties against two strains: S. Aureus and E. coli. When compared to conventional ciprofloxacin, compound C-04 demonstrated good to exceptional antibacterial efficacy against two distinct strains. they were further tested utilizing the carrageenan-induced paw edema method for anti-inflammatory efficacy. By using the HRBC membrane stabilizing test method, Compound C-05 showed strong anti-inflammatory action, while Compounds C-05 &and C-06 demonstrated noteworthy anti-inflammatory activity.
Genetic analysis of pyrazinamide resistance: mutations in the pncA gene among clinical isolates of multi-drug resistant Mycobacterium Tuberculosis
Authors:   Department of Microbiology, JSS Medical College, JSSAHER, Mysore. India, Tejashree A Tejashree A
Published: May 2024

Pyrazinamide (PZA) resistance presents a significant challenge in tuberculosis (TB) management, particularly in multi-drug resistant (MDR) cases. Understanding the genetic basis of PZA resistance is crucial for effective treatment strategies. This review provides a comprehensive overview of recent advancements in molecular characterization of PZA resistance, focusing on mutations in the pncA, rpsA, and panD genes. We discuss the prevalence of PZA resistance, mechanisms of resistance, and the utility of genetic analysis in early diagnosis. Key findings from studies investigating PZA resistance in clinical isolates are summarized, highlighting the predominant role of pncA mutations. Additionally, we explore the significance of mutations in rpsA and panD genes, elucidating alternative pathways to PZA resistance. Insights from genetic analysis have implications for personalized treatment approaches and TB control programs. Future directions in research and the potential of molecular methods in enhancing PZA susceptibility testing are also discussed.
Op verkenning in de digitale frontlinie: de mogelijke toepassingen van kunstmatige intelligentie bij de Koninklijke Marechaussee
Authors: Bootsma Jorrit , van Staveren Mariel
Published: May 2024

Exploring the digital frontline: possible applications of artificial intelligence within the Royal Netherlands Marechausssee

The security domain is currently facing major challenges, both internationally and nationally. The Royal Netherlands Marechaussee is therefore committed to the development of artificial intelligence (AI) to improve its effectiveness. This article describes three possible applications of AI within the Marechaussee: the virtual border guard, smart analysis of sensor data, and autonomous robotics for security tasks. The article then discusses a number of potential problems related to the use of AI: the effectiveness, bias and transparency of algorithms, and the lack of a legal framework. Examples and mitigating measures are given for each of the potential problems.
Ethische aspecten bij het ontwikkelen en toepassen van AI
Authors: Steen Marc
Published: May 2024

Ethical aspects in developing and applying AI. A method for reflection and deliberation

This article discusses some ethical aspects involved in developing and applying AI systems: positive contribution, human autonomy, privacy, justice, and transparency. It would be good if the people involved in development and application consider such ethical aspects explicitly and carefully. To this end, they can organize a process of reflection and deliberation: a series of meetings in which, for example, data scientists, software engineers, lawyers, civil servants, human rights experts and citizens discuss such ethical aspects. Rapid Ethical Deliberation is discussed as an example of such an approach, with some examples from the justice and security domain. Finally, a brief discussion follows on the added value of transdisciplinary approaches (ELSA) and virtue ethics for organizing such meetings.
Een herstelrechtelijk perspectief op vrijheidsbeperkende en -benemende straffen
Authors: Slump Gert Jan , Claessen Jacques
Published: May 2024

A restorative justice perspective on liberty-restricting and -depriving sentences

In their article, Gert Jan Slump and Jacques Claessen provide a restorative justice perspective on liberty-restricting and -depriving sentences. About 85% of the cases in which a prison sentence is currently imposed in the Netherlands involve custodial sentences of less than six months. Precisely in those cases, according to the authors, an alternative with more focus on resocialization/rehabilitation and restoration should be given priority. This should primarily involve community service and electronic detention. Moreover, in the context of these criminal sanctions, there is much more room to work on the so-called four restorative justice challenges: restoration/recovery of the self, restoration with one’s own network, restoration with the victim and restoration with community and society. According to the authors, this may also be the case in the context of small-scale detention, characterized by the principles of proximity and normalization. Also, this form of ‘societal detention’ can offer a solution for offenders who, for lack of their own home, do not qualify for electronic home detention. Finally, Slump and Claessen identify developments within the forensic context that are relevant for shaping detention of the future, of which they give an outline at the end of their contribution.
Herstel bij de tenuitvoerlegging van (levens) lange gevangenisstraffen
Authors: Meijer Sonja
Published: May 2024

Restorative justice in the enforcement of (life) long prison sentences

What room is there for restorative justice in the enforcement of (life) long prison sentences? Based on the current international and national legal-normative framework, this contribution argues that there is room for restorative justice in the enforcement phase. Moreover, based on ECtHR case law and legal sociology literature, it argues that rehabilitation and restorative justice are inextricably linked. Life prisoners should be offered a real prospect of release, given ECtHR case law. Release may follow if the offender has made sufficient progress in his rehabilitation. For that to actually happen, attention must be paid to restorative justice during execution. It is observed that attention to restorative justice is largely lacking in the current laws and regulations on the enforcement of (life) long prison sentences, but also that there are opportunities to embed restorative justice more firmly in them.
Herstelrecht en detentie in Vlaanderen
Authors: Aertsen Ivo , Beck Miriam , Lauwaert Katrien
Published: May 2024

Restorative justice and detention in Flanders

In this practice oriented contribution an overview is given on the state of affairs of restorative justice related initiatives and developments in various detention settings in the Flemish part of Belgium. An introductory section first provides a contextualisation of restorative detention within the general development of restorative justice in Belgium since the early 1990s. This is followed by a concise, but complete overview of restorative justice practices and programmes in residential centres for juvenile delinquents: both victim-offender mediation programmes and other restorative justice initiatives are presented, as they have become an integral part of trajectories in the treatment of young persons. Then, restorative justice programmes in prisons working with adult offenders are discussed. These relate to restorative justice practices in a strict sense, such as victim-offender mediation, but also concern dialogue groups between victims and offenders and mediation in non-related cases, and the operation of a compensation fund based on dialogue with the victim and voluntary work by the inmate. Other restorative oriented developments in prisons are being dealt with as well, as they are part of rehabilitation programmes offered by social services in the community. Special attention is given to the recent development of small-scale detention and transition houses and their potential to implement restorative approaches, focusing on their close relationship with local communities. The overview of restorative detention in Flanders concludes with some critical reflections on the scope and the hoped-for innovative character of institutional reform.
Hoe kun je een gedetineerde persoon bewegen om stil te staan bij wat er gebeurd is?
Authors: Kampert Evert
Published: May 2024

How can you move a detained person to reflect on what happened? Reflections from a recovery counsellor

In Dutch prisons restorative ways of working are integrated more and more in the daily life and training modules for the detainees. In some of the correctional institutions a special person dedicated to the topic is hired; the so-called ‘restorative consultant’ (herstelconsulent). Evert Kampert is such a consultant and works for several years in the prison in Nieuwegein. He describes in this practice note how they work on a restorative prison culture. This is a culture where they try to motivate everyone working within the institution to focus on restoring the disturbed relationship between the offender, his network, the victim and society. It is also a culture where it is normalized to talk about the offence and what can be done to avoid such mistakes again. One of the trainings Kampert is involved with is called ‘Clearing Rubble’ (Puinruimen). The course is explained in detail.
Over de randen van de muren: transmuraal herstelgericht werken voor kinderen met een vader in detentie
Authors: Smeenk Anouk , Tumer Nuray , Höing Mechtild , Claes Bart
Published: May 2024

Transmural restorative work for children with a father in detention

This article discusses transmural restorative work focusing on children with fathers in detention. It highlights the significant impact of parental incarceration on childrens’ well-being and emphasizes the need for a restorative approach to address their needs. The project that is being discussed, ‘Parent in Prison’, aims to explore how these children can be identified and supported through action research. One of the main challenges within the project is the collaboration among all practice partners and clarifying the roles and tasks, as well as responsibilities towards these families. We conclude that in order to identify, reach and support these children and their families, all parties have to acknowledge the severe impact of parental incarceration on children and take shared ownership over the unintended consequences of the detention through working together restoratively.
TOURISM PRICING STRATEGIES
Authors:   Senior lecturer, Karshi Engineering-Economics Institute, Uzbekistan, Murodova Nargiza
Published: May 2024

Tourism pricing strategies are vital for businesses in the travel and hospitality sector to maximize revenue, attract and retain customers, and stay competitive. These strategies range from value-based pricing, which relies on the perceived value to the customer, to dynamic pricing, adjusting costs in real-time based on market demand. Other approaches include discount pricing for off-peak periods, package deals offering combined services, psychological pricing to make costs seem more attractive, penetrationpricing to quickly gain market share, premium pricing for exclusive experiences, seasonal adjustments, cost-plus pricing to cover expenses and ensure profit, and geographical pricing to account for regional economic differences. Each strategy has its unique implications and is chosen based on the business’s goals, market conditions, and customer preferences.
Comparative analysis of power consumption time series in deprived and developed regions of Iran
Authors:   University of Oklahoma Norman, USA, Safarishaal Masoud
Published: May 2024

This paper presents a comparative analysis of power consumption time series at 12 o'clock every day between 2020 and 2022 for one distribution network in Sistan and one in Tehran. The aim of this study is to compare the development and climate differences between these regions, as well as the impact of social, industrial, and environmental factors. By comparing a deprived area with an area in the capital, we aim to identify potential disparities in power consumption and identify potential areas for improvement. We employed the CRP tool software and toolkit for time series analysis and used various methods to compare and predict the predictability of each time series. Our findings suggest significant differences in power consumption between the two regions, which could be attributed to socio-economic and environmental factors. Overall, this study sheds light on the potential impact of regional differences on power consumption and highlights the need for further research in this area.
Encéphalites limbiques non infectieuses à propos de deux cas et revue de la littérature.
Authors: Admin Admin , DIAKHOUMPA A. B  , , DEME H  , PEROU A  , NIANG E
Published: May 2024

We report 2 cases of non-infectious limbic encephalitis diagnosed on MRI. These were an 85-year-old man and a 22-year-old woman seen in a neurological emergency department in whom cerebral MRI had shown bilateral internal temporal hypersigns in FLAIR for both patients, a T1 isosignal rising after gadolinium injection in one patient and a T1 hyposignal in the other. There were no abnormalities in diffusion and T2* weighting. The CSF virus test for HSV was negative.
The thoraco-abdomino-pelvic CT scan and immunological tests performed in the etiological work-up had found a positive ovarian teratoma and anti-NMDAr autoantibodies in the young woman. The diagnosis of limbic encephalitis of paraneoplastic origin was retained in the young woman and the origin was not specified in the elderly subject. Under immunoglobulin therapy followed by corticosteroid therapy and teratoma removal in the young girl, the evolution was favourable.
MRI is the imaging modality of choice in the diagnostic approach to non-infectious limbic encephalitis.
Résumé
Nous rapportons 2 cas d’encéphalite limbique non infectieuse diagnostiqués à l’IRM. Il s’agissait d’un homme de 85 ans et d’une femme de 22 ans reçus dans un tableau d’urgence neurologique chez qui L’IRM cérébrale avait montré des hypersignaux temporaux internes bilatéraux en FLAIR pour les deux patients, en isosignal en T1 se rehaussant après injection de gadolinium chez un patient et un hyposignal en T1 chez l’autre. Il n y’avait pas d’anomalie à la diffusion et en pondération T2*. La recherche du virus HSV dans le LCR était négative.
Le scanner thoraco-abdomino-pelvien et les tests immunologiques réalisés dans le bilan étiologique avait trouvé un tératome ovarien et des autoanticorps anti-NMDAr positifs chez la jeune femme. Le diagnostic d’encéphalite limbique d’origine paranéoplasique était retenu chez la jeune femme, l’origine n’était pas précisée chez le sujet âgé. Sous immunoglobulinothérapie suivie d’une corticothérapie et d’une exérèse du tératome chez la jeune fille, l’évolution était favorable.
L’IRM constitue la modalité d’imagerie de choix dans l’approche diagnostique des encéphalites limbiques non infectieuses.
Caractéristiques des opérateurs du post traitement en imagerie tomodensitométrique thoracique dans les hôpitaux de référence en Côte d’Ivoire.
Authors: Administrateur- JAIM  , KONAN Anhum Nicaise  , KOUAME-KOUTOUAN Annick  , ZUNON-KIPRE Eric  , KOUASSI-ABOUKOUA N’go Nathalie  , N’DRIN N’guessan Konan Julien  , TOURE Massiami
Published: May 2024

Objective: To analyse the profile and knowledge of the operators and their application of post-processing in CT imaging in our hospital practice.
Material and method: Cross-sectional study carried out over 32 weeks in the imaging departments of the 3rd level hospitals of the health pyramid of Côte d'Ivoire. It concerned senior and junior radiologists, trainee doctors and radiology interns with more than 4 semesters of training. Socio-professional parameters, knowledge and characteristics of post treatment use were studied.
Results: We registered 79 operators. Juniors represented 58.2% of the respondents. Sex ratio was 2.1 and the average age was 37.4 years. In 65-83%, the practitioners partially identified all the main post-processing algorithms, useful for the diagnosis and follow-up of common thoracic pathologies. The post processing algorithms were underused. 3D surface, CAD and quantification were never used because 24.3% of the participants had never heard of them, 68.2% did not know how to use them and 7.6% did not know how to find them on their post treatment station. The majority (80.3%) of respondents had not received any specific training in post processing.
Conclusion: Post-processing in thoracic CT was insufficiently known and under-used by radiologists due to a lack of specific training.
RESUME
Objectif : Analyser le profil des opérateurs, leur connaissance et application du post-traitement en imagerie TDM dans notre pratique hospitalière.
Matériels et méthodes : Étude transversale réalisée sur 32 semaines, au sein des services d’imagerie des hôpitaux de 3ème niveau de la pyramide sanitaire de Côte d’Ivoire. Elle a concerné les radiologues séniors et juniors, médecins apprenants et internes en radiologie ayant plus de 4 semestres de formation. Les paramètres socio-professionnels, la connaissance et les caractéristiques d’utilisation du post traitement ont été étudiés. 
Résultats : Nous avons recensé 79 opérateurs. Les juniors représentaient 58,2% des répondants. Le sex ratio était de 2,1 et l’âge moyen de 37,4 ans. Dans 65 à 83% des cas, les praticiens ont partiellement identifié tous les principaux algorithmes de post traitement, utiles au diagnostic et au suivi des pathologies thoraciques courantes. Les algorithmes de post traitement étaient sous utilisés. Le 3D surfacique, le CAD et la quantification n’étaient jamais utilisés car 24,3% des participants n’en avait jamais entendu parler, 68,2% ne savaient pas les utiliser et 7,6% ne savait pas les retrouver sur leur station de post traitement. La majorité (80,3%) des répondants n’avait pas reçu de formation spécifique en post traitement.
Conclusion : Le post traitement en TDM thoracique était insuffisamment connu et sous utilisé par les radiologues en raison d’une insuffisance de formation spécifique.