bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk of Mortality and Cardiovascular Events in Patients with Chronic Obstructive Pulmonary Disease Treated with Azithromycin, Roxithromycin, Clarithromycin, and Amoxicillin
Authors: Alispahic Imane Achir , Eklöf Josefin , Sivapalan Pradeesh , Jordan Alexander Ryder , Harboe Zitta Barrella , Biering-Sørensen Tor , Jensen Jens-Ulrik Stæhr
Published: April 2024

Background: Prior research has raised concerns regarding the use of macrolides and their association with an increased risk of cardiovascular events. Methods: We conducted a cohort study, where we explored the cardiovascular risks associated with the treatment of COPD patients using macrolide antibiotics–namely azithromycin, clarithromycin, and roxithromycin—with amoxicillin serving as a reference. The study focused on COPD patients in an outpatient setting and included a thorough 3-year follow-up. Patients were categorized into four groups based on their treatment. The primary analysis utilized an adjusted Cox model, supplemented by sensitivity analysis through inverse probability of treatment weighting. Results: No significant differences were found in major adverse cardiovascular events (MACE—stroke, acute myocardial infarction, cardiovascular death) between the macrolide groups, and the amoxicillin/hazard ratios (HR) were azithromycin HR = 1.01, clarithromycin HR = 0.99, and roxithromycin HR = 1.02. Similarly, sensitivity analysis showed no disparities in all-cause mortality and cardiovascular death among the groups. Conclusions: Overall, the study revealed no evidence of increased risk of MACE, all-cause mortality, or cardiovascular death in COPD patients treated with these macrolides compared to amoxicillin over a 3-year period.
The Clinical Implications of KRAS Mutations and Variant Allele Frequencies in Pancreatic Ductal Adenocarcinoma
Authors: Nusrat Faria , Khanna Akshay , Jain Aditi , Jiang Wei , Lavu Harish , Yeo Charles J. , Bowne Wilbur , Nevler Avinoam
Published: April 2024

The KRAS proto-oncogene is a major driver of pancreatic tumorigenesis and is nearly ubiquitously mutated in pancreatic ductal adenocarcinoma (PDAC). KRAS point mutations are detected in over 90% of PDAC cases, and these mutations have been shown to be associated with worse therapy response and overall survival. Pathogenic KRAS mutations are mostly limited to codons 12, 13 and 61, with G12D, G12V, G12R, Q61H, and G13D accounting for approximately 95% of the mutant cases. Emerging data have shown the importance of specific mutant subtypes, as well as KRAS variant allele frequency on clinical prognosis. Furthermore, novel technologies and therapies are being developed to target specific mutant subtypes, with encouraging early results. In this paper, we aim to review the recent studies regarding the relative impact of specific mutant KRAS subtypes on oncologic outcomes, the application of variant allele frequency in next generation sequencing analyses, and the ongoing research into therapies targeting specific mutant KRAS subtypes.
A Female-Specific Treatment Group for ADHD—Description of the Programme and Qualitative Analysis of First Experiences
Authors: de Jong M. , Wynchank D. S. M. R. , Michielsen M. , Beekman A. T. F. , Kooij J. J. S.
Published: April 2024

Background: The diagnostics and treatment of attention-deficit/hyperactivity disorder (ADHD) in women remain insufficient. Fluctuations of reproductive hormones during the premenstrual period, postpartum period, and (peri)menopause are neglected, even though they impact ADHD symptoms and associated mood disorders. Therefore, we created a female-specific treatment group for women with ADHD and premenstrual worsening of ADHD and/or mood symptoms. Methods: We describe the group programme and underlying rationale, offering a qualitative analysis of the participants’ evaluation. Results: The seven bi-weekly sessions foreground the menstrual cycle and address several ADHD-specific topics in relation to this cyclical pattern. Concurrently, women track their menstrual cycle and (fluctuating) ADHD and mood symptoms with an adjusted premenstrual calendar. In total, 18 women (25–47 years) participated in three consecutive groups. We analysed the evaluation of the last group. Participants experienced the group as a safe and welcoming space. Recognition was valued by all. The topics discussed were deemed valuable, and the structure suited them well. Completing the premenstrual calendar augmented the awareness and recognition of individual cyclical symptoms. A lifespan approach increased self-understanding. Participants took their menstrual cycle more seriously, prioritising self-acceptance and self-care. Conclusions: Exploring a cyclical approach in a group setting seems to be a positive addition to treatment for female ADHD.
Effects of Rinsing with Povidone-Iodine during Step II Periodontal Therapy: A Systematic Review and Meta-Analysis
Authors: Svellenti Leonardo , Karacic Jelena , Herzog Johannes , Tanner Moritz , Sahrmann Philipp
Published: April 2024

Background and Objectives: Antiseptics have been suggested to enhance the outcomes of non-surgical periodontal treatment (NSPT). Among these, povidone-iodine (PVP-iodine) was reported to significantly reduce periodontal pocket depths (PPDs). The aim of this study was to systematically re-assess the existing literature regarding the potential benefit of using PVP-iodine in step II periodontal therapy. Material and Methods: The scientific literature was systematically searched across electronic libraries for randomized controlled trials employing PVP-iodine during NSPT through to September 2023, using search items related to PVP-iodine and periodontitis. The selection process was performed by two independent reviewers. The primary outcomes were reductions in periodontal probing depth (PPD) and clinical attachment level (CAL). When reasonable, a meta-analysis of the included studies was performed. Results: Initially, 799 records were identified. After abstract and title screening and fulltext revision, 15 RCTs were included. The data from eight studies were merged in meta-analyses. The use of PVP-iodine had no significant effect on PPD reduction at 6 months (means [standard deviation]: −0.12 mm [−0.33; 0.09]) but it did at 12 months (−0.29 mm [−0.56; −0.02]). CAL was significantly better at 6 (−0.42 mm [−0.64; −0.20]) and 12 months (−0.39 mm [−0.66; −0.11]). Conclusions: PVP-iodine rinsing during NSPT may slightly improve patients’ PPD and CAL.
Advancements in Hybrid Cellulose-Based Films: Innovations and Applications in 2D Nano-Delivery Systems
Authors: Ramezani Ghazaleh , Stiharu Ion , van de Ven Theo G. M. , Nerguizian Vahe
Published: April 2024

This review paper delves into the realm of hybrid cellulose-based materials and their applications in 2D nano-delivery systems. Cellulose, recognized for its biocompatibility, versatility, and renewability, serves as the core matrix for these nanomaterials. The paper offers a comprehensive overview of the latest advancements in the creation, analysis, and application of these materials, emphasizing their significance in nanotechnology and biomedical domains. It further illuminates the integration of nanomaterials and advanced synthesis techniques that have significantly improved the mechanical, chemical, and biological properties of hybrid cellulose-based materials.
Advancing 3D Dental Implant Finite Element Analysis: Incorporating Biomimetic Trabecular Bone with Varied Pore Sizes in Voronoi Lattices
Authors: Alemayehu Dawit Bogale , Todoh Masahiro , Huang Song-Jeng
Published: April 2024

The human mandible’s cancellous bone, which is characterized by its unique porosity and directional sensitivity to external forces, is crucial for sustaining biting stress. Traditional computer- aided design (CAD) models fail to fully represent the bone’s anisotropic structure and thus depend on simple isotropic assumptions. For our research, we use the latest versions of nTOP 4.17.3 and Creo Parametric 8.0 software to make biomimetic Voronoi lattice models that accurately reflect the complex geometry and mechanical properties of trabecular bone. The porosity of human cancellous bone is accurately modeled in this work using biomimetic Voronoi lattice models. The porosities range from 70% to 95%, which can be achieved by changing the pore sizes to 1.0 mm, 1.5 mm, 2.0 mm, and 2.5 mm. Finite element analysis (FEA) was used to examine the displacements, stresses, and strains acting on dental implants with a buttress thread, abutment, retaining screw, and biting load surface. The results show that the Voronoi model accurately depicts the complex anatomy of the trabecular bone in the human jaw, compared to standard solid block models. The ideal pore size for biomimetic Voronoi lattice trabecular bone models is 2 mm, taking in to account both the von Mises stress distribution over the dental implant, screw retention, cortical bone, cancellous bone, and micromotions. This pore size displayed balanced performance by successfully matching natural bone’s mechanical characteristics. Advanced FEA improves the biomechanical understanding of how bones and implants interact by creating more accurate models of biological problems and dynamic loading situations. This makes biomechanical engineering better.
Impact of Oxygen Content on Flame Dynamics in a Non-Premixed Gas Turbine Model Combustor
Authors: Chen Mingmin , Huang Xinbo , Wang Zhaokun , Zheng Hongtao , Deng Fuquan
Published: April 2024

In this study, large eddy simulation (LES) was used to investigate the dynamic characteristics of diffusion flames in a swirl combustion chamber at an oxygen content of 11–23 wt% and temperature of 770 K. The proper orthogonal decomposition (POD) method was employed to obtain flame dynamic modes. The results indicate that oxygen content has a significant impact on the downstream flow and flame combustion characteristics of the swirl combustion chamber. With oxygen content increasing, the size of the recirculation zone is reduced, and the flame field fluctuations are intensified. The pressure and heat release fluctuations under different oxygen contents were analyzed using frequency spectrum analysis. Finally, the flame modes were analyzed using the POD method, and it was found that the coherent structures are asymmetric relative to the local coordinate system. At an oxygen content of 11 wt%, they exhibit larger coherent structures, while at an oxygen content of 23 wt%, they exhibit numerous turbulent structures.
Efficacy and Safety of Anti-CD38 Monoclonal Antibodies in Patients with Relapsed or Refractory Multiple Myeloma: A Meta-Analysis of Randomized Clinical Trials
Authors: Moraes Francisco Cezar Aquino de , Sano Vitor Kendi Tsuchiya , Lôbo Artur de Oliveira Macena , Kelly Francinny Alves , Morbach Victória , Pasqualotto Eric , Burbano Rommel Mario Rodríguez
Published: April 2024

The benefit of associating anti-CD38 monoclonal antibodies to proteasome inhibitor (PI)/immunomodulatory agent (IA) and dexamethasone in the treatment of patients with relapsed or refractory multiple myeloma (MM) remains unclear. PubMed, Embase, and Cochrane Library databases were searched for randomized controlled trials that investigated the addition of anti-CD38 monoclonal antibodies to a therapy composed of PI/IA and dexamethasone versus PI/IA and dexamethasone alone for treating relapsed or refractory MM. Hazard ratios (HRs) or risk ratios (RRs) were computed for binary endpoints, with 95% confidence intervals (CIs). Six studies comprising 2191 patients were included. Anti-CD38 monoclonal antibody significantly improved progression-free survival (HR 0.52; 95% CI 0.43–0.61; p < 0.001) and overall survival (HR 0.72; 95% CI 0.63–0.83; p < 0.001). There was a significant increase in hematological adverse events, such as neutropenia (RR 1.41; 95% CI 1.26–1.58; p < 0.01) and thrombocytopenia (RR 1.14; 95% CI 1.02–1.27; p = 0.02), in the group treated with anti-CD38 monoclonal antibody. Also, there was a significant increase in non-hematological adverse events, such as dyspnea (RR 1.72; 95% CI 1.38–2.13; p < 0.01) and pneumonia (RR 1.34; 95% CI 1.13–1.59; p < 0.01), in the group treated with anti-CD38 monoclonal antibody. In conclusion, the incorporation of an anti-CD38 monoclonal antibody demonstrated a promising prospect for reshaping the established MM treatment paradigms.
Microfluidics-Based Drying–Wetting Cycles to Investigate Phase Transitions of Small Molecules Solutions
Authors: Verma Ajay , Mateo Tiphaine , Quintero Botero Juan , Mohankumar Nishanth , Fraccia Tommaso P.
Published: April 2024

Drying–wetting cycles play a crucial role in the investigation of the origin of life as processes that both concentrate and induce the supramolecular assembly and polymerization of biomolecular building blocks, such as nucleotides and amino acids. Here, we test different microfluidic devices to study the dehydration–hydration cycles of the aqueous solutions of small molecules, and to observe, by optical microscopy, the insurgence of phase transitions driven by self-assembly, exploiting water pervaporation through polydimethylsiloxane (PDMS). As a testbed, we investigate solutions of the chromonic dye Sunset Yellow (SSY), which self-assembles into face-to-face columnar aggregates and produces nematic and columnar liquid crystal (LC) phases as a function of concentration. We show that the LC temperature–concentration phase diagram of SSY can be obtained with a fair agreement with previous reports, that droplet hydration–dehydration can be reversibly controlled and automated, and that the simultaneous incubation of samples with different final water contents, corresponding to different phases, can be implemented. These methods can be further extended to study the assembly of diverse prebiotically relevant small molecules and to characterize their phase transitions.
Platelet, Antiplatelet Therapy and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review
Authors: Boccatonda Andrea , Del Cane Lorenza , Marola Lara , D’Ardes Damiano , Lessiani Gianfranco , di Gregorio Nicoletta , Ferri Claudio , Cipollone Francesco , Serra Carla , Santilli Francesca , Piscaglia Fabio
Published: April 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is not only related to traditional cardiovascular risk factors like type 2 diabetes mellitus and obesity, but it is also an independent risk factor for the development of cardiovascular disease. MASLD has been shown to be independently related to endothelial dysfunction and atherosclerosis. MASLD is characterized by a chronic proinflammatory response that, in turn, may induce a prothrombotic state. Several mechanisms such as endothelial and platelet dysfunction, changes in the coagulative factors, lower fibrinolytic activity can contribute to induce the prothrombotic state. Platelets are players and addresses of metabolic dysregulation; obesity and insulin resistance are related to platelet hyperactivation. Furthermore, platelets can exert a direct effect on liver cells, particularly through the release of mediators from granules. Growing data in literature support the use of antiplatelet agent as a treatment for MASLD. The use of antiplatelets drugs seems to exert beneficial effects on hepatocellular carcinoma prevention in patients with MASLD, since platelets contribute to fibrosis progression and cancer development. This review aims to summarize the main data on the role of platelets in the pathogenesis of MASLD and its main complications such as cardiovascular events and the development of liver fibrosis. Furthermore, we will examine the role of antiplatelet therapy not only in the prevention and treatment of cardiovascular events but also as a possible anti-fibrotic and anti-tumor agent.
Investigation of the Allelopathic Effect of Two Invasive Plant Species in Rhizotron System
Authors: Bakacsy László , Kardos Luca Viktória , Szepesi Ágnes , Nagy Krisztina Napsugár , Vasas Andrea , Feigl Gábor
Published: April 2024

A key question in plant invasion biology is why invasive plants are more competitive in their introduced habitat than in their native habitat. Studies show that invasive species exhibit allelopathy, influencing other plants by releasing chemicals. Research on allelopathy uses in vitro tests, investigating effects on seed germination and seedling development. Although soil plays a role in modifying allelopathic effects, observations with soil are rare and almost nothing is known about the root development of test plants developing in soil and the effects of allelopathic compounds on root architecture. Our study evaluates the allelopathic effects of false indigo-bush (Amorpha fruticosa L.) and common milkweed (Asclepias syriaca L.) on oilseed rape growth as a model plant. The rhizotron system was used to study the effect of morphology and root architecture. Leaf–soil mixtures at 0.5%, 1%, and 5% concentrations were used. Shoot and root development was strongly inhibited at 5%. But there was no difference between the allelopathy of the two species, and the application of lower concentrations did not show any effect, demonstrating that soil has a significant modifying effect on their allelopathy. Our results highlight that the development of roots growing in the soil is also worth investigating in connection with allelopathy, which can strengthen the ecological importance of allelochemicals during successful invasions.
Factors Associated with Success of Switching to Faricimab for Neovascular Age-Related Macular Degeneration Refractory to Intravitreal Aflibercept
Authors: Machida Akira , Oishi Akio , Ikeda Junichiro , Kurihara Junko , Yoneda Ai , Tsuiki Eiko , Hirata Yuki , Murakami Ryuya , Kitaoka Takashi
Published: April 2024

We investigated the factors associated with the success of switching to faricimab for type 1 macular neovascularization (MNV) refractory to intravitreal aflibercept (IVA). This retrospective cohort study included patients with type 1 MNV who were switched to faricimab because they were refractory to IVA at two centers. The primary endpoint was a more than two-week extension of the treatment interval after 6 months. In addition, factors related to the success or failure of extension and visual and anatomical outcomes were assessed. The analysis included 43 eyes from 43 patients. Extended dosing intervals of >2 weeks were identified in 14 eyes (32.6%). A short dosing interval before switching, absence of polypoidal lesions, and thin central choroidal thickness before switching were identified as factors involved in successful extension. For patients with refractory type 1 MNV, switching to faricimab is a safe and potential option to extend existing dosing intervals.
Oxidation Behavior of Pre-Strained Polycrystalline Ni3Al-Based Superalloy
Authors: Guo Rui , Ding Jian , Wang Yujiang , Feng Haomin , Chen Linjun , Yang Jie , Xia Xingchuan , Zhao Yingli , Li Jun , Ji Shuang , Luo Junyi
Published: April 2024

The harsh service environment of aeroengine hot-end components requires superalloys possessing excellent antioxidant properties. This study investigated the effect of pre-strain on the oxidation behavior of polycrystalline Ni3Al-based superalloys. The growth behaviors of oxidation products were analyzed by scanning electron microscope, transmission electron microscope, X-ray Photoelectron Spectroscopy and Raman spectroscopy. The results indicated that the 5% pre-strained alloys exhibited lower mass gain, shallower oxidation depth and more compact oxide film structures compared to the original alloy. This is mainly attributed to the formation of rapid diffusion paths for Al atoms diffusing to the surface under 5% pre-strain, which promotes the faster formation of protective Al2O3 film while continuing to increase the pre-strain to 25% results in less protective transient oxidation behavior being aggravated due to the increase in dislocation density within the alloy, which prevents the timely formation of the protective Al2O3 film, resulting in uneven oxidation behavior on the alloy.
The Effects of Organically Modified Lithium Magnesium Silicate on the Rheological Properties of Water-Based Drilling Fluids
Authors: Luo Taotao , Li Jun , Xu Jiangen , Wang Jun , Zhang Lianxi , Yu Zeya
Published: April 2024

To address the problem of insufficient temperature and salt resistance of existing polymer viscosity enhancers, we designed an organic–inorganic hybrid composite as a viscosity enhancer for water-based drilling fluids, named LAZ, and it was prepared by combining a water-soluble monomer and lithium magnesium silicate (LMS) using an intercalation polymerization method. The composite LAZ was characterized using Fourier transform infrared spectroscopy, transformed target X-ray diffractometry, scanning electron microscopy, and thermogravimetric analysis. The rheological properties of the composite LAZ were evaluated. The composite LAZ was used as a water-based drilling fluid viscosity enhancer, and the temperature and salt resistance of the drilling fluid were evaluated. The results showed that the composite LAZ presented a complex reticulation structure in an aqueous solution. This reticulation structure intertwined with each other exhibited viscosity-enhancing properties, which can enhance the suspension properties of water-based drilling fluids. The aqueous solution of the composite LAZ has shear dilution properties. As shear rate increases, shear stress becomes larger. The yield stress value of the aqueous solution increases as the composite LAZ’s concentration increases. The aqueous solution of the composite LAZ exhibits strong elastic characteristics with weak gel properties. The addition of the composite LAZ to 4% sodium bentonite-based slurry significantly increased the apparent viscosity and dynamic shear of the drilling fluid. The drilling fluids containing the composite LAZ had good temperature resistance at 150 °C and below. The rheological properties of brine drilling fluids containing the composite LAZ changed slightly before and after high-temperature aging at 150 °C.
Correlation between the Chemical Structure of (Meth)Acrylic Monomers and the Properties of Powder Clear Coatings Based on the Polyacrylate Resins
Authors: Pojnar Katarzyna , Pilch-Pitera Barbara
Published: April 2024

This paper presents studies on the influence of the chemical structure of (meth)acrylic monomers on the properties of powder coatings based on polyacrylate resins. For this purpose, a wide range of monomers were selected—2-hydroxyethyl methacrylate (HEMA), methyl methacrylate (MMA), n-butyl acrylate (nBA), tert-butyl acrylate (tBA), dodecyl acrylate (DA), ethyl acrylate (EA) and benzyl acrylate (BAZ)—for the synthesis of the polyacrylate resin. The average molecular mass and molecular mass distribution of the synthesized resins were measured by gel permeation chromatography (GPC). The glass transition temperature (Tg) and viscosity of polyacrylate resins were determined by using differential scanning calorimetry (DSC) and a Brookfield viscometer. These parameters were necessary to obtain information about storage stability and behavior during the application of powder clear coatings. Additionally, DSC was also used to checked the course of the low-temperature curing reaction between the hydroxyl group contained in the polyacrylate resin and the blocked polyisocyanate group derived from a commercial agent such as Vestanat B 1358/100. The properties of the cured powder clear coatings were tested, such as: roughness, gloss, adhesion to the steel surface, hardness, cupping, scratch resistance, impact resistance and water contact angle. The best powder clear coating based on the polyacrylate resin L_HEMA/6MMA/0.5nBA/0.5DA was characterized as having good scratch resistance (550 g) and adhesion to the steel surface, a high water contact angle (93.53 deg.) and excellent cupping (13.38 mm). Moreover, its crosslinking density (CD) and its thermal stability was checked by using dynamic mechanical analysis (DMA) and thermogravimetric analysis (TGA).
Assessment of the Thermal Properties of Gypsum Plaster with Plastic Waste Aggregates
Authors: Vidales-Barriguete Alejandra , Barreira Eva , Gomes Dias Susana
Published: April 2024

Building material manufacturers must support new production models that encourage the manufacture of more efficient and sustainable products. This includes thinking about savings in the use of raw materials, a contribution to the energy efficiency of buildings during their useful life, and a reduction in the generation and deposit of waste in landfills. In this research, an analysis of the thermal properties of gypsum composites added with plastic waste is carried out using the most common methods, the steady state method and the transient plane source method, and the effect of water saturation on these composites is tested. The results show an improvement in the thermal performance of the composites (values reduced with respect to the reference by 4–7%), despite their heterogeneity, as well as a variation in the measurements carried out, depending on the method used for the measurements (variation up to 10%). It is also found that the degree of humidity negatively affects the thermal conductivity coefficient but, on the contrary, this coefficient is not altered in the composites with plastic waste, due to their lower hygroscopicity. Therefore, it is considered that the proposed eco-plasters are a good alternative to traditional plasters, with which to contribute to the achievement of the objectives of the current European directives on waste and circular economy.
Machine Learning Prediction of Quantum Yields and Wavelengths of Aggregation-Induced Emission Molecules
Authors: Bi Hele , Jiang Jiale , Chen Junzhao , Kuang Xiaojun , Zhang Jinxiao
Published: April 2024

The aggregation-induced emission (AIE) effect exhibits a significant influence on the development of luminescent materials and has made remarkable progress over the past decades. The advancement of high-performance AIE materials requires fast and accurate predictions of their photophysical properties, which is impeded by the inherent limitations of quantum chemical calculations. In this work, we present an accurate machine learning approach for the fast predictions of quantum yields and wavelengths to screen out AIE molecules. A database of about 563 organic luminescent molecules with quantum yields and wavelengths in the monomeric/aggregated states was established. Individual/combined molecular fingerprints were selected and compared elaborately to attain appropriate molecular descriptors. Different machine learning algorithms combined with favorable molecular fingerprints were further screened to achieve more accurate prediction models. The simulation results indicate that combined molecular fingerprints yield more accurate predictions in the aggregated states, and random forest and gradient boosting regression algorithms show the best predictions in quantum yields and wavelengths, respectively. Given the successful applications of machine learning in quantum yields and wavelengths, it is reasonable to anticipate that machine learning can serve as a complementary strategy to traditional experimental/theoretical methods in the investigation of aggregation-induced luminescent molecules to facilitate the discovery of luminescent materials.
Design and Control Performance Optimization of Variable Structure Hydrostatic Drive Systems for Wheel Loaders
Authors: Wang Xin , Wang Zhongyu , Wang Songlin , Cai Wei , Wu Qingjie , Ma Wenxing
Published: April 2024

The traditional loader drive system is based on the hydraulic torque converter as the key component, and its gear is shifted through the coordination of the clutch and gearbox, which greatly increases power loss and operator fatigue. To address the above problem, a variable-structure hydrostatic drive system is proposed. This system adopts a closed-loop design and adjusts the displacement of the pump and dual motors to follow the throttle opening of the vehicle, achieving automatic gear shifting and smooth speed regulation. It can also automatically change the system structure according to the vehicle’s speed, meeting the vehicle’s demand for rapid switching output of high torque and high speed. At the same time, in the displacement matching control process, an adaptive sliding mode control scheme based on radial basis function neural network compensation is proposed. This scheme designs an adaptive hyperparameter update strategy according to the characteristics of the system to effectively compensate for changes in uncertain factors. Experimental results show that, compared to traditional drive systems, this system has the characteristics of simple operation, smooth speed regulation, and high fuel economy.
Approaches for Streamlining Performance Control by Monte Carlo Modeling
Authors: Cipu Elena , Cipu Ruxandra , Michnea Ştefania
Published: April 2024

For decades, cancer has remained a persistent health challenge; this project represents a significant stride towards refining treatment approaches and prognostic insights. Proton beam therapy, a radiation therapy modality employing high-energy protons to target various malignancies while minimizing damage to adjacent healthy tissue, holds immense promise. This study analyzes the relationship between delivered radiation doses and patient outcomes, using various approximation functions and graphical representations for comparison. Statistical analysis is performed through the Monte Carlo method based on repeated sampling to estimate the variables of interest in this analysis, namely, the survival rates, financial implications, and medical effectiveness of proton beam therapy. To this end, open-source data from research centers that publish patient outcomes were utilized. The second study considered the estimation of pay gaps that can have long-lasting effects, leading to differences in retirement savings, wealth accumulation, and overall financial security. After finding a representative sample containing the relevant variables that contribute to pay gaps, such as gender, race, experience, education, and job role, MC modeling is used to simulate a range of possible pay gap estimates. Based on the Monte Carlo results, a sensitivity analysis is performed to identify which variables have the most significant impact on pay gaps.
Virtual Reality-Based Assessment for Rehabilitation of the Upper Limb in Patients with Parkinson’s Disease: A Pilot Cross-Sectional Study
Authors: Bissolotti Luciano , Artiles-Sánchez Justo , Alonso-Pérez José Luís , Fernández-Carnero Josué , Abuín-Porras Vanesa , Sinatti Pierluigi , Villafañe Jorge Hugo
Published: April 2024

Background and Objectives: This study aimed to examine the responsiveness and concurrent validity of a serious game and its correlation between the use of serious games and upper limbs (UL) performance in Parkinson’s Disease (PD) patients. Materials and Methods: Twenty-four consecutive upper limbs (14 males, 8 females, age: 55–83 years) of PD patients were assessed. The clinical assessment included: the Box and Block test (BBT), Nine-Hole Peg test (9HPT), and sub-scores of the Unified Parkinson’s Disease Rating-Scale Motor section (UPDRS-M) to assess UL disability. Performance scores obtained in two different tests (Ex. A and Ex. B, respectively, the Trolley test and Mushrooms test) based on leap motion (LM) sensors were used to study the correlations with clinical scores. Results: The subjective fatigue experienced during LM tests was measured by the Borg Rating of Perceived Exertion (RPE, 0–10); the BBT and 9HPT showed the highest correlation coefficients with UPDRS-M scores (ICCs: −0.652 and 0.712, p < 0.05). Exercise A (Trolley test) correlated with UPDRS-M (ICC: 0.31, p < 0.05), but not with the 9HPT and BBT tests (ICCs: −0.447 and 0.390, p < 0.05), while Exercise B (Mushroom test) correlated with UPDRS-M (ICC: −0.40, p < 0.05), as did these last two tests (ICCs: −0.225 and 0.272, p < 0.05). The mean RPE during LM tests was 3.4 ± 3.2. The evaluation of upper limb performance is feasible and does not induce relevant fatigue. Conclusions: The analysis of the ICC supports the use of Test B to evaluate UL disability and performance in PD patients, while Test A is mostly correlated with disability. Specifically designed serious games on LM can serve as a method of impairment in the PD population.
Cutaneous Calcified Mass of Foot in Pseudohypoparathyoidism: Case Report
Authors: Lee Sang Heon , Kim Sung Hwan , Choi Seung Jin , Lee Young Koo
Published: April 2024

Soft tissue calcifications frequently appear on imaging studies, representing a prevalent but non-specific discovery, varying from a local reaction without clear cause to suggesting an underlying systemic condition. Because calcifications like these can arise from various causes, an accurate differential diagnosis is crucial. Differential diagnosis entails a methodical assessment of the patient, encompassing clinical presentation, medical history, radiological and pathological findings, and other pertinent factors. Through scrutiny of the patient’s medical and trauma history, we can refine potential causes of calcification to vascular, metabolic, autoimmune, neoplastic, or traumatic origins. Furthermore, routine laboratory assessments, including serum levels of calcium, phosphorus, ionized calcium, vitamin D metabolites, and parathyroid hormone (PTH), aid in identifying metabolic etiologies. We describe a rare occurrence of osteoma cutis in a 15-year-old female patient with a history of pseudohypoparathyroidism (PHP) and Albright’s hereditary osteodystrophy (AHO). The patient presented with a painful mass on the lateral side of her left foot. The diagnosis was based on medical history, laboratory tests, and imaging, leading to an excisional biopsy and complete pain relief post-surgery. Understanding such rare occurrences and related conditions is crucial for accurate diagnosis and management.
Optimising Percutaneous Coronary Interventions: The Impact of Stent Type and Diameter on Long-Term Clinical Outcomes in Large Coronary Arteries
Authors: Gök Gökhan , Akçay Murat , Yıldırım Ufuk , Çoksevim Metin , Soylu Korhan , Şahin Mahmut
Published: April 2024

Background and Objectives: Our study aimed to reveal the effect of using 4 mm bare-metal stents (BMS), 4 mm drug-eluting stents (DES), or 3 mm DES with 4 mm diameter balloon post-dilation strategies on long-term clinical outcomes and endpoints for large-diameter coronary artery percutaneous coronary intervention (PCI). Materials and Methods: In our study, patients who had undergone PCI were retrospectively screened between January 2014 and July 2020. The study included 350 patients and was divided into three groups; Group I (n = 134) included patients with direct 4.0 mm BMS implantation, Group II (n = 109) included patients with direct 4.0 DES implantation, and Group III (n = 107) included patients with 4mm NC post-dilatation after 3 mm DES implantation. Primary endpoints were determined as target lesion revascularisation, cardiac mortality, and myocardial infarction associated with the target vessel. Our secondary endpoint was all-cause mortality. Results: No differences were observed between the groups in terms of the baseline variables. Stent length was the highest in Group II and the shortest in Group III. There were no significant differences between the groups regarding major adverse cardiovascular events (MACE). Conclusions: Our study suggests that in percutaneous coronary interventions for non-complex lesions, there is no significant difference in MACE outcomes when directly implanting a 4 mm diameter DES, a 4 mm diameter BMS, or a 3 mm diameter DES, followed by post-dilation with an appropriately sized NC balloon when the target vessel diameter is in the range of 4 to 4.4 mm.
Untapped Opportunities in Additive Manufacturing with Metals: From New and Graded Materials to Post-Processing
Authors: Mosallanejad Mohammad Hossein , Ghanavati Reza , Behjat Amir , Taghian Mohammad , Saboori Abdollah , Iuliano Luca
Published: April 2024

Metal additive manufacturing (AM) is an innovative manufacturing method with numerous metallurgical benefits, including fine and hierarchical microstructures and enhanced mechanical properties, thanks to the utilization of a local heat source and the rapid solidification nature of the process. High levels of productivity, together with the ability to produce complex geometries and large components, have added to the versatile applicability of metal AM with applications already implemented in various sectors such as medicine, transportation, and aerospace. To further enhance the potential benefits of AM in the context of small- to medium-scale bulk production, metallurgical complexities should be determined and investigated. Hence, this review paper focuses on three significant metallurgical aspects of metal AM processes: in situ alloying, functionally graded materials, and surface treatments for AM parts. The current text is expected to offer insights for future research works on metal AM to expand its potential applications in various advanced manufacturing sectors.
A Novel Asymmetric Trench SiC Metal–Oxide–Semiconductor Field-Effect Transistor with a Poly-Si/SiC Heterojunction Diode for Optimizing Reverse Conduction Performance
Authors: Yu Yiren , Cheng Zijun , Hu Yi , Lv Ruiyi , Hu Shengdong
Published: April 2024

In this paper, a novel asymmetric trench SiC MOSFET with a Poly-Si/SiC heterojunction diode (HJD-ATMOS) is designed to improve its reverse conduction characteristics and switching performance. This structure features an integrated heterojunction diode, which improves body diode characteristics without affecting device static characteristics. The heterojunction diode acts as a freewheeling diode during reverse conduction, reducing the cut-in voltage (Vcut-in) to a lower level than conventional asymmetric trench SiC MOSFET (C-ATMOS), while maintaining a similar breakdown voltage. Meanwhile, the split gate structure reduces gate-to-drain charge (Qgd). Through TCAD simulation, the HJD-ATMOS decreases Vcut-in by 53.04% compared to the C-ATMOS. Both Qgd and switching loss are reduced, with a decrease of 31.91% in Qgd and 40.29% in switching loss.
A Comprehensive Review on Shiga Toxin Subtypes and Their Niche-Related Distribution Characteristics in Shiga-Toxin-Producing E. coli and Other Bacterial Hosts
Authors: Wang Xuan , Yu Daniel , Chui Linda , Zhou Tiantian , Feng Yu , Cao Yuhao , Zhi Shuai
Published: April 2024

Shiga toxin (Stx), the main virulence factor of Shiga-toxin-producing E. coli (STEC), was first discovered in Shigella dysenteriae strains. While several other bacterial species have since been reported to produce Stx, STEC poses the most significant risk to human health due to its widespread prevalence across various animal hosts that have close contact with human populations. Based on its biochemical and molecular characteristics, Shiga toxin can be grouped into two types, Stx1 and Stx2, among which a variety of variants and subtypes have been identified in various bacteria and host species. Interestingly, the different Stx subtypes appear to vary in their host distribution characteristics and in the severity of diseases that they are associated with. As such, this review provides a comprehensive overview on the bacterial species that have been recorded to possess stx genes to date, with a specific focus on the various Stx subtype variants discovered in STEC, their prevalence in certain host species, and their disease-related characteristics. This review provides a better understanding of the Stx subtypes and highlights the need for rapid and accurate approaches to toxin subtyping for the proper evaluation of the health risks associated with Shiga-toxin-related bacterial food contamination and human infections.
Genomoviruses in Liver Samples of Molossus molossus Bats
Authors: Couto Roseane da Silva , Abreu Wandercleyson Uchôa , Rodrigues Luís Reginaldo Ribeiro , Marinho Luis Fernando , Morais Vanessa dos Santos , Villanova Fabiola , Pandey Ramendra Pati , Deng Xutao , Delwart Eric , da Costa Antonio Charlys , Leal Elcio
Published: April 2024

CRESS-DNA encompasses a broad spectrum of viruses documented across diverse organisms such as animals, plants, diatoms, fungi, and marine invertebrates. Despite this prevalence, the full extent of these viruses’ impact on the environment and their respective hosts remains incompletely understood. Furthermore, an increasing number of viruses within this category lack detailed characterization. This investigation focuses on unveiling and characterizing viruses affiliated with the Genomoviridae family identified in liver samples from the bat Molossus molossus. Leveraging viral metagenomics, we identified seven sequences (MmGmV-PA) featuring a circular DNA genome housing two ORFs encoding replication-associated protein (Rep) and capsid protein (Cap). Predictions based on conserved domains typical of the Genomoviridae family were established. Phylogenetic analysis revealed the segregation of these sequences into two clades aligning with the genera Gemycirculavirus (MmGmV-06-PA and MmGmV-07-PA) and Gemykibivirus (MmGmV-01-PA, MmGmV-02-PA, MmGmV-03-PA, MmGmV-05-PA, and MmGmV-09-PA). At the species level, pairwise comparisons based on complete nucleotide sequences indicated the potential existence of three novel species. In summary, our study significantly contributes to an enhanced understanding of the diversity of Genomoviridae within bat samples, shedding light on previously undiscovered viral entities and their potential ecological implications.
State of the Art in Hygienic Quality of Food Ice Worldwide: A Ten-Year Review
Authors: Triggiano Francesco , Apollonio Francesca , Diella Giusy , Marcotrigiano Vincenzo , Caggiano Giuseppina
Published: April 2024

Ice consumption has widely increased over the last decade. Cases of ice contamination by various microorganisms (bacteria, viruses and fungi) have been documented in the literature. In this review, we summarize the findings of selected articles on the hygienic and sanitary quality of food ice from 1 January 2013 to 31 December 2023. A total of 14 articles found via the PubMed search engine during the study period were reviewed. From the comparison between the ice produced on an industrial scale and the ice produced on a local scale in food businesses, the latter was found to be more contaminated by microorganisms. The most detected bacteria included Escherichia coli, coliforms, Pseudomonas spp., Staphylococcus aureus; three studies evaluated the presence of Vibrio cholerae and Vibrio parahaemolyticus; two studies highlighted the presence of viruses (Rotavirus and Norovirus). Finally, two studies detected the presence of fungi (molds and yeasts). Almost all authors of the studies argued that ice contamination also depends on the hygienic–sanitary quality of the ice-making machines. The results show that the information currently available in the literature on the hygienic–sanitary quality of ice is incomplete and that future national and international scientific studies need to be carried out.
Numerical Analysis of Crack Propagation in an Aluminum Alloy under Random Load Spectra
Authors: Wang Fangli , Zheng Jie , Liu Kai , Tong Mingbo , Zhou Jinyu
Published: April 2024

This study develops a rapid algorithm coupled with the finite element method to predict the fatigue crack propagation process and select the enhancement factor for the equivalent random load spectrum of accelerated fatigue tests. The proposed algorithm is validated by several fatigue tests of an aluminum alloy under the accelerated random load spectra. In the validation process, two kinds of panels with different geometries and sizes are used to calculate the stress intensity factor, critical crack length, and crack propagation life. The simulated and experimental findings indicate that when the aluminum alloy is in a low plasticity state, the crack propagation life exhibits a linear relationship with the acceleration factor. When the aluminum alloy is in a high plasticity state, this study proposes an empirical formula to calculate the equivalent stress intensity factor and crack propagation life. The normalized empirical formula is independent of the geometry and size of different samples, although the fracture processes are different in the two kinds of panels used in our study. Overall, the numerical method proposed in this paper can be applied to predict the fatigue crack propagation life for the random spectrum of large samples based on the results of the simulated accelerated crack propagation process and the accelerated fatigue tests of small samples to reduce the cost and time of the testing.
Synergism with Shikimic Acid Restores β-Lactam Antibiotic Activity against Methicillin-Resistant Staphylococcus aureus
Authors: Hou Limin , Ye Minqi , Wang Xiaoyu , Zhu Yifan , Sun Xueyan , Gu Ruiheng , Chen Liangzhu , Fang Binghu
Published: April 2024

Methicillin-resistant Staphylococcus aureus (MRSA) has evolved into a dangerous pathogen resistant to beta-lactam antibiotics (BLAs) and has become a worrisome superbug. In this study, a strategy in which shikimic acid (SA), which has anti-inflammatory and antibacterial activity, is combined with BLAs to restart BLA activity was proposed for MRSA treatment. The synergistic effects of oxacillin combined with SA against oxacillin resistance in vitro and in vivo were investigated. The excellent synergistic effect of the oxacillin and SA combination was confirmed by performing the checkerboard assay, time-killing assay, live/dead bacterial cell viability assay, and assessing protein leakage. SEM showed that the cells in the control group had a regular, smooth, and intact surface. In contrast, oxacillin and SA or the combination treatment group exhibited different degrees of surface collapse. q-PCR indicated that the combination treatment group significantly inhibited the expression of the mecA gene. In vivo, we showed that the combination treatment increased the survival rate and decreased the bacterial load in mice. These results suggest that the combination of oxacillin with SA is considered an effective treatment option for MRSA, and the combination of SA with oxacillin in the treatment of MRSA is a novel strategy.
Promoting Effect of Ball Milling on the Functionalization and Catalytic Performance of Carbon Nanotubes in Glycerol Etherification
Authors: Ptaszyńska Karolina , Malaika Anna , Morawa Eblagon Katarzyna , Figueiredo José Luís , Kozłowski Mieczysław
Published: April 2024

A facile and eco-friendly approach using in situ-generated 4-benzenediazonium sulfonate (BDS) was applied to prepare highly functionalized carbon nanotubes (CNTs). The effectiveness of this functionalization was additionally enhanced by a green and short-time ball milling process applied beforehand. The obtained BDS-modified CNTs presented significant activity in glycerol etherification, producing tert-butyl glycerol ethers, which are considered promising fuel additives. Excellent results of ~56% glycerol conversion and ~10% yield of higher-substituted tert-butyl glycerol ethers were obtained within just 1 h of reaction at 120 °C using a low catalyst loading of only 2.5 wt.%. Furthermore, the sulfonated CNTs were reusable over several reaction cycles, with only a minor decrease in activity. Additionally, the sample activity could be restored by a simple regeneration approach. Finally, a clear correlation was found between the content of -SO3H groups on the surface of CNTs and the catalytic performances of these materials in glycerol etherification. Improved interaction between functionalized ball-milled CNTs and the reactants was also suggested to positively affect the activity of these catalysts in the tested process.