bluuebunny/crossref_metadata_2025 huggingface dataset:
Calculating component temperatures in gearboxes for transient operation conditions
Authors: Paschold Constantin , Sedlmair Martin , Lohner Thomas , Stahl Karsten
Published: September 2021

The knowledge of component temperatures during transient operation conditions is essential for an optimal design of a gearbox. This is because critical peak temperatures limit the transferable power as well as the load capacity. Moreover, understanding the thermal behavior of the gearbox is key to improving its efficiency. Therefore, the Thermal Network Method (TNM) of the calculation program WTplus was extended to calculate component temperatures in gearboxes for transient operation conditions. Specifically, the TNM considers the component masses and specific heat capacities of each node modelling the gearbox structure. This enables the algorithm to compute a corresponding system of differential equations and thus determine the temperature change over time. Therefore, WTplus can be used to identify critical gearbox component temperatures during load cycles. The applied method was validated with measurements collected at the FZG gear efficiency test rig.
A plant-specific DYRK kinase DYRKP coordinates cell morphology in Marchantia polymorpha
Authors: Furuya Tomoyuki , Shinkawa Haruka , Kajikawa Masataka , Nishihama Ryuichi , Kohchi Takayuki , Fukuzawa Hideya , Tsukaya Hirokazu
Published: September 2021

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are activated via the auto-phosphorylation of conserved tyrosine residues in their activation loop during protein translation, and they then phosphorylate serine/threonine residues on substrates. The DYRK family is widely conserved in eukaryotes and is composed of six subgroups. In plant lineages, DYRK homologs are classified into four subgroups, DYRK2s, yet another kinase1s, pre-mRNA processing factor 4 kinases, and DYRKPs. Only the DYRKP subgroup is plant-specific and has been identified in a wide array of plant lineages, including land plants and green algae. It has been suggested that in Arabidopsis thaliana DYRKPs are involved in the regulation of centripetal nuclear positioning induced by dark light conditions. However, the molecular functions, such as kinase activity and the developmental and physiological roles of DYRKPs are poorly understood. Here, we focused on a sole DYRKP ortholog in the model bryophyte, Marchantia polymorpha, MpDYRKP. MpDYRKP has a highly conserved kinase domain located in the C-terminal region and shares common sequence motifs in the N-terminal region with other DYRKP members. To identify the roles of MpDYRKP in M. polymorpha, we generated loss-of-function Mpdyrkp mutants via genome editing. Mpdyrkp mutants exhibited abnormal, shrunken morphologies with less flattening in their vegetative plant bodies, thalli, and male reproductive organs, antheridial receptacles. The surfaces of the thalli in the Mpdyrkp mutants appeared uneven and disordered. Moreover, their epidermal cells were drastically altered to a narrower shape when compared to the wild type. These results suggest that MpDYRKP acts as a morphological regulator, which contributes to orderly tissue morphogenesis via the regulation of cell shape.
An Intra-Cycle Optimal Control Framework for Ventricular Assist Devices Based on Atrioventricular Plane Displacement Modeling
Authors: Zeile Clemens , Rauwolf Thomas , Schmeisser Alexander , Mizerski Jeremi Kaj , Braun-Dullaeus Rüdiger C. , Sager Sebastian
Published: September 2021

A promising treatment for congestive heart failure is the implementation of a left ventricular assist device (LVAD) that works as a mechanical pump. Modern LVADs work with adjustable constant rotor speed and provide therefore continuous blood flow; however, recently undertaken efforts try to mimic pulsatile blood flow by oscillating the pump speed. This work proposes an algorithmic framework to construct and evaluate optimal pump speed policies with respect to generic objectives. We use a model that captures the atrioventricular plane displacement, which is a physiological indicator for heart failure. We employ mathematical optimization to adapt this model to patient specific data and to find optimal pump speed policies with respect to ventricular unloading and aortic valve opening. To this end, we reformulate the cardiovascular dynamics into a switched system and thereby reduce nonlinearities. We consider system switches that stem from varying the constant pump speed and that are state dependent such as valve opening or closing. As a proof of concept study, we personalize the model to a selected patient with respect to ventricular pressure. The model fitting results in a root-mean-square deviation of about 6 mmHg. The optimization that considers aortic valve opening and ventricular unloading results in speed modulation akin to counterpulsation. These in silico findings demonstrate the potential of personalized hemodynamical optimization for the LVAD therapy.
Macroseismic risk classification of historical constructions: the LEXSIS approach
Authors: Puncello Irene , Caprili Silvia , Bonanni Elisa
Published: September 2021

The present paper deals with the elaboration of a methodology to assess the macro-seismic risk of monumental historical buildings, representing a fundamental part of the European cultural assets. Monumental buildings typically arise from a very complex constructive and morphological evolution process characterised by modifications occurred over the centuries. Therefore, they are usually heterogeneous buildings similar to 'structural aggregates' rather than single constructions and characterised by a structural behaviour depending on the mutual interaction of different structural units. An accurate knowledge process can allow the determination of structural units within the complex: such units can be therefore analysed using a specific evaluation form conceived to provide a 'risk ranking' of the different portions constituting the aggregate and accounting for vulnerability, exposure and seismic hazard parameters. The proposed methodology exploits what is already used to quickly determine structural features and eventual damages in the post-earthquake phase for ordinary buildings, introducing specific aspects typical of historical-cultural heritage requiring attention. According to the results achieved, retrofit interventions or deepen investigations can be planned for units provided by a higher position in the risk scale, optimising and rationally planning the use of available economic and time resources. In the present work, the proposed methodology is applied to the monumental complex of the Certosa di Calci, Pisa (Italy).
Using TRIZ10 for enhancing creativity in engineering design education
Authors: Cano-Moreno Juan David , Arenas Reina José Manuel , Sánchez Martínez Francisca Victoria , Cabanellas Becerra José María
Published: September 2021

One of the popular creativity methods to solve technical problems is the Theory of Inventive Problem Solving, (TRIZ), however, requires a considerable investment of time. A teaching methodology for a simplified version of TRIZ (TRIZ10) has been developed for reducing learning time and improving the creative process in solving technical problems. This method has been applied in a small group of engineering design students as a proof of concept. The evaluation of the results obtained shows that students achieved adequate learning of this creative technique (75% overall efficiency). This method has led to the doubling of the number ideas developed by students compared to those generated before learning TRIZ10; further, it also improves a 10% the average degree of novelty for these ideas.
Optimal approximation to unitary quantum operators with linear optics
Authors: Garcia-Escartin Juan Carlos , Gimeno Vicent , Moyano-Fernández Julio José
Published: September 2021

Linear optical systems acting on photon number states produce many interesting evolutions, but cannot give all the allowed quantum operations on the input state. Using Toponogov’s theorem from differential geometry, we propose an iterative method that, for any arbitrary quantum operatorUacting onnphotons inmmodes, returns an operator$$\widetilde{U}$$U~which can be implemented with linear optics. The approximation method is locally optimal and converges. The resulting operator$$\widetilde{U}$$U~can be translated into an experimental optical setup using previous results.
The estimation of a preference-based single index for the IBS-QoL by mapping to the EQ-5D-5L in patients with irritable bowel syndrome
Authors: Sturkenboom Rosel , Keszthelyi Daniel , Brandts Lloyd , Weerts Zsa Zsa R. M. , Snijkers Johanna T. W. , Masclee Ad A. M. , Essers Brigitte A. B.
Published: September 2021

Purpose

The Irritable Bowel Syndrome Quality of Life (IBS-QoL) questionnaire is a commonly used and validated IBS-specific QoL instrument. However, this questionnaire is in contrast to the EQ-5D-5L, not preference-based and as such does not allow calculation of QALYs. The objective of this study was to describe the convergent- and known-group validity of both questionnaires and to develop a mapping algorithm from EQ-5D-5L which enable IBS-QoL scores to be transformed into utility scores for use in economic evaluations.

Methods

We used data from two multicenter randomized clinical trials, which represented the estimation and external validation dataset. The convergent validity was investigated by examining correlations between the EQ-5D-5L and IBS-QoL and the known-group validity by calculating effect sizes. Ordinary least squares (OLS), censored least absolute deviations (CLAD), and mixture models were used in this mapping approach.

Results

283 IBS patients were included (n = 189 vs. n = 84). Mean IBS-QoL score was 71.13 (SD 15.66) and mean EQ-5D-5L utility score was 0.73 (SD 0.19). The overall sensitivity of the IBS-QoL and EQ-5D-5L to discriminate between patient and disease characteristics was similar. CLAD model 4, containing the total IBS-QoL score and squared IBS-SSS (IBS severity scoring system), was chosen as the most appropriate model to transform IBS-QoL scores into EQ-5D-5L utility scores.

Conclusion

This study reports the development of an algorithm where the condition-specific questionnaire IBS-QoL can be used to calculate utility values for use in economic evaluations. Including a clinical measure, IBS-SSS, in the model improved the performance of the algorithm.
un/doing clientification: Zur Konstruktion und Dekonstruktion des Klient*innenstatus in der stationären Sozialen Altenarbeit
Authors: Höppner Grit
Published: September 2021

Ohne Klient*innen wäre Soziale Arbeit nicht möglich. Die Bezeichnung „Klient*in“ wirft jedoch die Frage auf, wer oder was genau damit gemeint ist und in welchem Verhältnis Soziale Arbeit zu Klient*innen steht. Dies ist im Handlungsfeld der stationären Sozialen Altenarbeit besonders relevant, in dem ältere Menschen in erster Linie als Bewohner*innen leben und lediglich kontextspezifisch zu Klient*innen werden. Diese fehlende Eindeutigkeit in der Zuschreibung des Klient*innenstatus hat auch zur Folge, dass der Auftrag der Sozialen Arbeit in diesem Handlungsfeld bisher nicht eindeutig definiert ist und die Einrichtung eines Sozialen Dienstes in Seniorenheimen keine Selbstverständlichkeit darstellt. Dieser Beitrag zielt auf eine Präzisierung des Klient*innenstatus in diesem Feld ab. Mit Hilfe der Heuristik desun/doing clientificationsoll bestimmt werden, wie der Klient*innenstatus konstruiert und dekonstruiert wird und welche Aufgaben der Mitarbeitenden des Sozialen Dienstes damit einhergehen. Dies wird mit Hilfe der Ergebnisse eines ethnographischen Forschungsprojektes veranschaulicht. Es werden all jene sozialen Praktiken dargestellt, in denen der Klient*innenstatus im praktischen Tun hervorgebracht, aufrechterhalten, in Frage gestellt oder irrelevant gemacht wird. Die Ergebnisse ermöglichen neue Impulse für das Verständnis des Klient*innenstatus in der stationären Sozialen Altenarbeit und verdeutlichen die Bedeutung des Sozialen Dienstes in Seniorenheimen.
Intraperitoneal-onlay-mesh repair with hernia defect closure via the hernial orifice approach: A case series of 49 patients
Authors: Mikamori Manabu , Nakahara Yujiro , Iwamoto Kazuya , Hyuga Satoshi , Naito Atsushi , Ohtsuka Masahisa , Furukawa Kenta , Moon Jeongho , Imasato Mitsunobu , Asaoka Tadafumi , Kishi Kentaro , Mizushima Tsunekazu
Published: September 2021

ABSTRACT

Introduction:

In intraperitoneal-onlay-mesh repair with hernia defect closure (IPOM-plus), the abdominal cavity can be reliably approached through the hernial orifice. Adhesions can then be detached, and the hernial orifice can be closed by direct visual manipulation.

Presentation of cases:

IPOM-plus via the hernial orifice approach was performed in 49 patients. First, an incision is made just above the hernial orifice to reach the abdominal cavity. Under direct visualization, the adhesions are dissected, and the mesh is inserted after laparoscopic manipulation. After closing the hernial orifice under direct visual manipulation, the mesh is fixed again under laparoscopic guidance.

Conclusions:

This technique has the advantages of an easy intra-abdominal approach and direct visual manipulation. No mesh infections were observed in this study, suggesting that it may be useful as a hybrid procedure.

Highlights
Assessment of the Responsibility of Local Governments in Indonesia for the Management of Refugee Care
Authors: Suyatna I Nyoman , Arsika I Made Budi , Satyawati Ni Gusti Ayu Dyah , Nordin Rohaida , Jones Balawyn
Published: September 2021

This article assesses the responsibility of local governments in Indonesia for the management of refugee care, following the enactment of Presidential Regulation No. 125 of 2016 concerning the Treatment of Refugees (the “PR”). It highlights the limited authority of local governments in handling refugee issues—which is an issue that cuts across several national legal and administrative regimes including Foreign Affairs, Human Rights, and Immigration. This article focuses on the constraints of local political dynamics and budgeting in allocating local government funds for refugee care. In addressing these concerns, the authors argue that the PR should be amended to explicitly define the role of local governments in managing refugee issues and to include the regional revenue and expenditure budget as a source of funding. In addition, the authors argue that local governments that are hosting refugees should establish relevant local regulations for implementation of the PR.
Non-negative integral matrices with given spectral radius and controlled dimension
Authors: YAZDI MEHDI
Published: September 2021

A celebrated theorem of Douglas Lind states that a positive real number is equal to the spectral radius of some integral primitive matrix, if and only if, it is a Perron algebraic integer. Given a Perron numberp, we prove that there is an integral irreducible matrix with spectral radiusp, and with dimension bounded above in terms of the algebraic degree, the ratio of the first two largest Galois conjugates, and arithmetic information about the ring of integers of its number field. This arithmetic information can be taken to be either the discriminant or the minimal Hermite-like thickness. Equivalently, given a Perron numberp, there is an irreducible shift of finite type with entropy$\log (p)$defined as an edge shift on a graph whose number of vertices is bounded above in terms of the aforementioned data.
Barriers to severe acute respiratory coronavirus virus 2 (SARS-CoV-2) testing reported by healthcare workers during the first pandemic wave at an academic center in Boston, Massachusetts
Authors: Zubiago Julia , Wurcel Alysse G. , Guardado Rubeen , Byhoff Elena
Published: September 2021

Healthcare workers (HCWs) experience barriers to severe acute respiratory coronavirus virus 2 (SARS-CoV-2) testing specific to their perceptions of access, and employment factors. A survey was sent to all employees at one Boston hospital to examine their perceived barriers to testing. HCWs who reported difficulty paying their bills were less likely to receive a SARS-CoV-2 test.
Transient linear stability of pulsating Poiseuille flow using optimally time-dependent modes
Authors: Kern J.S. , Beneitez M. , Hanifi A. , Henningson D.S.
Published: September 2021

Time-dependent flows are notoriously challenging for classical linear stability analysis. Most progress in understanding the linear stability of these flows has been made for time-periodic flows via Floquet theory focusing on time-asymptotic stability. However, little attention has been given to the transient intracyclic linear stability of periodic flows since no general tools exist for its analysis. In this work, we explore the potential of using the recent framework of the optimally time-dependent (OTD) modes (Babaee & Sapsis,Proc. R. Soc. Lond.A, vol. 472, 2016, 20150779) to extract information about both the transient and the time-asymptotic linear stability of pulsating Poiseuille flow. The analysis of the instantaneous OTD modes in the limit cycle leads to the identification of the dominant instability mechanism of pulsating Poiseuille flow by comparing them with the spectrum and the eigenmodes of the Orr–Sommerfeld operator. In accordance with evidence from recent direct numerical simulations, it is found that structures akin to Tollmien–Schlichting waves are the dominant feature over a large range of pulsation amplitudes and frequencies but that for low pulsation frequencies these modes disappear during the damping phase of the pulsation cycle as the pulsation amplitude is increased beyond a threshold value. The maximum achievable non-normal growth rate during the limit cycle was found to be nearly identical to that in plane Poiseuille flow. The existence of subharmonic perturbation cycles compared with the base flow pulsation is documented for the first time in pulsating Poiseuille flow.
Transient dispersion process of active particles
Authors: Jiang Weiquan , Chen Guoqian
Published: September 2021

Active particles often swim in confined environments. The transport mechanisms, especially the global one as reflected by the Taylor dispersion model, are of great practical interest to various applications. For the active dispersion process in confined flows, previous analytical studies focused on the long-time asymptotic values of dispersion characteristics. Only several numerical studies preliminarily investigated the temporal evolution. Extending recent studies of Jiang & Chen (J. Fluid Mech., vol. 877, 2019, pp. 1–34; vol. 899, 2020, A18), this work makes a semi-analytical attempt to investigate the transient process. The temporal evolution of the local distribution in the confined-section–orientation space, drift, dispersivity and skewness, is explored based on moments of distributions. We introduce the biorthogonal expansion method for solutions because the classic integral transform method for passive transport problems is not applicable due to the self-propulsion effect. Two types of boundary condition, the reflective condition and the Robin condition for wall accumulation, are imposed respectively. A detailed study on spherical and ellipsoidal swimmers dispersing in a plane Poiseuille flow demonstrates the influences of the swimming, shear flow, initial condition, wall accumulation and particle shape on the transient dispersion process. The swimming-induced diffusion makes the local distribution reach its equilibrium state faster than that of passive particles. Although the wall accumulation significantly affects the evolution of the local distribution and the drift, the time scale to reach the Taylor regime is not obviously changed. The shear-induced alignment of ellipsoidal particles can enlarge the dispersivity but impacts slightly on the drift and the skewness.
Large-scale energetic coherent structures and their effects on wall mass transfer rate behind orifice in round pipe
Authors: Shan F. , Qin S.Y. , Xiao Y. , Watanabe A. , Kano M. , Zhou F.Y. , Liu Z.C. , Liu W. , Tsuji Y.
Published: September 2021

This paper first uses a low-speed stereoscopic particle image velocimetry (SPIV) system to measure the convergent statistical quantities of the flow field and then simultaneously measure the time-resolved flow field and the wall mass transfer rate by a high-speed SPIV system and an electrochemical system, respectively. We measure the flow field and wall mass transfer rate under upstream pipe Reynolds numbers between 25 000 and 55 000 at three specific locations behind the orifice plate. Moreover, we apply proper orthogonal decomposition (POD), stochastic estimation and spectral analysis to study the properties of the flow field and the wall mass transfer rate. More importantly, we investigate the large-scale coherent structures’ effects on the wall mass transfer rate. The collapse of the wall mass transfer rates’ spectra by the corresponding time scales at the three specific positions of orifice flow suggest that the physics of low-frequency wall mass transfer rates are probably the same, although the flow fields away from the wall are quite different. Furthermore, the spectra of the velocity reconstructed by the most energetic eigenmodes agree well with the wall mass transfer rate in the low-frequency region, suggesting that the first several energetic eigenmodes capture the flow dynamics relevant to the low-frequency variation of the wall mass transfer. Stochastic estimation results of the velocity field associated with large wall mass transfer rate at all three specific locations further reveal that the most energetic coherent structures are correlated with the wall mass transfer rate.
Clouds of bubbles in a viscoplastic fluid
Authors: Chaparian Emad , Frigaard Ian A.
Published: September 2021

Viscoplastic fluids can hold bubbles/particles stationary by balancing the buoyancy stress with the yield stress – the key parameter here is the yield number

$Y$

, the ratio of the yield stress to the buoyancy stress. In the present study, we investigate a suspension of bubbles in a yield-stress fluid. More precisely, we compute how much is the gas fraction

$\phi$

that could be held trapped in a yield-stress fluid without motion. Here the goal is to shed light on how the bubbles feel their neighbours through the stress field and to compute the critical yield number for a bubble cloud beyond which the flow is suppressed. We perform two-dimensional computations in a full periodic box with randomized positions of the monosized circular bubbles. A large number of configurations are investigated to obtain statistically converged results. We intuitively expect that for higher volume fractions, the critical yield number is larger. Not only here do we establish that this is the case, but also we show that short-range interactions of bubbles increase the critical yield number even more dramatically for bubble clouds. The results show that the critical yield number is a linear function of volume fraction in the dilute regime. An algebraic expression model is given to approximate the critical yield number (semi-empirically) based on the numerical experiment in the studied range of

$0\le \phi \le 0.31$

, together with lower and upper estimates.
Testing the area–altitude balance ratio (AABR) and accumulation–area ratio (AAR) methods of calculating glacier equilibrium-line altitudes
Authors: Oien Rachel P. , Rea Brice R. , Spagnolo Matteo , Barr Iestyn D. , Bingham Robert G.
Published: September 2021

In this study, we compare equilibrium-line altitudes (ELAs) calculated using the area–altitude balance ratio (AABR) and the accumulation–area ratio (AAR) methods, with measured ELAs derived from direct field observations. We utilise a GIS toolbox to calculate the ELA for 64 extant glaciers by applying the AABR and AAR methods to DEMs and polygons of their geometry. The calculated ELAs (c-ELAs) are then compared to measured zero-net balance ELAs (znb-ELAs) obtained from mass-balance time series held by the WGMS for the same glaciers. The correlation between znb-ELAs and AABR (1.56)/AAR (0.58) c-ELAs is very strong, with an r2 = 0.99. The smallest median difference between znb-ELAs and c-ELAs (i.e. 65.5 m) is obtained when a globally representative AABR of 1.56 is used. When applied to palaeoglacier-climate applications, this difference translates to ~0.42°C, well within the uncertainty of palaeotemperature proxies used to determine mean summer temperature at the ELA. The more widely used mean AABR of 1.75 is shown to be statistically invalid due to the skewness of the dataset. On this basis, when calculating glacier ELAs, we recommend the use of a global AABR value of 1.56.
El manejo territorial de los camélidos en la circumpuna de Atacama desde el Arcaico al Formativo (10.000-2400 aP): Una aproximación isotópica y taxonómica
Authors: Mendoza Patricio López , Samec Celeste , Núñez Lautaro , Carrasco Carlos , Loyola Rodrigo , Cartajena Isabel
Published: September 2021

En este trabajo se presentan los resultados de los análisis de isótopos estables (δ13Ccol, δ15Ncol, δ13Capa y δ18Oapa) realizados en huesos de camélidos de sitios de Puripica, Tulán y Salar de Punta Negra (Región de Antofagasta, Chile), dentro de una secuencia que abarca desde el Arcaico temprano hasta el Formativo temprano. Estos datos se cotejaron con datos osteométricos y genéticos de camélidos silvestres y domésticos con el objetivo de comprender el uso de los espacios de caza y pastoreo. Los resultados correspondientes a las muestras de los periodos Arcaico temprano y medio (10.000-5300 aP) obedecen a las características ambientales registradas durante dicho lapso temporal en el área. Para el Arcaico tardío (5300-4000 aP) y el Formativo temprano (3100-2400 aP) se observa una distribución de valores isotópicos relativamente similar. Sin embargo, debido a la alta variabilidad de tamaños dentro de los camélidos domésticos, no es posible definir el uso de ciertas áreas de pastura sobre otras. Al mismo tiempo, los valores isotópicos de carbono y nitrógeno de la fase Tarajne (3700-3200 aP) se muestran poco variables, patrón que se explica por el uso de áreas acotadas para la caza de animales silvestres y/o el pastoreo de animales domésticos.
Dietary fibre intake and risk of prediabetes in China: results from the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) Cohort Study
Authors: Zhang Shunming , Meng Ge , Zhang Qing , Liu Li , Yao Zhanxin , Wu Hongmei , Gu Yeqing , Wang Yawen , Zhang Tingjing , Wang Xuena , Zhang Juanjuan , Sun Shaomei , Wang Xing , Zhou Ming , Jia Qiyu , Song Kun , Qi Lu , Niu Kaijun
Published: September 2021

High dietary fibre intake has been associated with a lower risk of diabetes, but the association of dietary fibre with prediabetes is only speculative, especially in China, where the supportive data from prospective studies are lacking. This study aimed to examine the association between dietary fibre intake and risk of incident prediabetes among Chinese adults. We performed a prospective analysis in 18 085 participants of the Tianjin Chronic Low-grade Systemic Inflammation and Health cohort study who were free of diabetes, prediabetes, cancer and CVD at baseline. Dietary data were collected using a validated 100-item FFQ. Prediabetes was defined based on the American Diabetes Association diagnostic criteria. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95 % CI. During 63 175 person-years of follow-up, 4139 cases of incident prediabetes occurred. The multivariable HR of prediabetes for the highest v. lowest quartiles were 0·85 (95 % CI 0·75, 0·98) (P for trend = 0·02) for total dietary fibre, 0·84 (95 % CI 0·74, 0·95) (P for trend < 0·01) for soluble fibre and 1·05 (95 % CI 0·93, 1·19) (P for trend = 0·38) for insoluble fibre. Fibre from fruits but not from cereals, beans and vegetables was inversely associated with prediabetes. Our results indicate that intakes of total dietary fibre, soluble fibre and fibre derived from fruit sources were associated with a lower risk of prediabetes.
The effect of probiotics/synbiotics supplementation on renal and liver biomarkers in patients with type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials
Authors: Abdollahi Shima , Meshkini Fatemeh , Clark Cain C. T. , Heshmati Javad , Soltani Sepideh
Published: September 2021

Despite the apparent beneficial effects of probiotics/synbiotics on glucose haemostasis, lipid profile and inflammatory responses, it is not clear whether these beneficial effects also impact renal and hepatic function in diabetes. Therefore, we sought to assess the effect of probiotics/synbiotics supplementation on renal and liver biomarkers in adults with type 2 diabetes mellitus (T2DM) using a systematic review and meta-analysis of randomised controlled trials (RCT). PubMed, Scopus, Web of Science and Cochrane Library were systematically searched, up to February 2021. The pooled weighted mean difference (WMD) was estimated using a random-effects model. The methodological quality of studies, as well as certainty of evidence, was assessed using standard scales. Fifteen related trials were identified. Meta-analysis of six trials, involving 426 participants, indicated that probiotics/synbiotics supplementation reduced serum levels of creatinine (WMD = −0·10 mg/dl, 95 % CI −0·20, −0·00; P = 0·01; I2 = 87·7 %; P-heterogeneity < 0·001), without any significant effect on blood urea nitrogen (BUN), glomerular filtration rate or microalbuminuria. No significant improvement was found on liver biomarkers following probiotics/synbiotics supplementation. The subgroup analysis showed a significant improvement in BUN when follow-up duration lasted for 12 weeks or more (WMD = −1·215 mg/dl, 95 % CI −1·933, −0·496; P = 0·001) and in creatinine levels in patients with renal dysfunction (WMD = −0·209 mg/dl, 95 % CI −0·322, −0·096; P < 0·001). Our results are insufficient to advocate the use of probiotics/synbiotics for improving renal or liver function in patients with T2DM. Indeed, due to the low certainty of evidence, these findings need to be affirmed in further high-quality RCT.
A new second intermediate host and phylogenetic relationships based on the ITS2 sequence of Isoparorchis sp. (Digenea: Isoparorchiidae) in Thailand
Authors: Jaruboonyakorn P. , Chontananarth T.
Published: September 2021

The genus Isoparorchis (Family: Isoparorchiidae) contains trematodes infecting the air bladder of freshwater catfishes in Asia and Australia. Isoparorchis spp. rely on freshwater shrimps and fishes as intermediate hosts. There is limited information about parasitic infections in freshwater shrimp in Thailand, and Isoparorchis infection in an intermediate host in this country has never been reported. Thus, this study reports infections in freshwater shrimp (Macrobrachium lanchesteri and Caridina sp.), including overall prevalence, mean intensity, morphological characters and molecular analyses. The parasite specimens were analysed by studying their morphological characters, together with a molecular approach based on internal transcribed spacer 2 (ITS2) sequence data. The overall prevalence and mean intensity of Isoparorchis infections were 92% and 1.89, respectively. The metacercariae were identified as Isoparorchis sp. based on their morphological characters and supported by the comparison with published ITS2 sequences of Isoparorchis species. The phylogenetic studies based on the ITS2 region demonstrated that all of the Isoparorchis sp. specimens in this study are distinct from Isoparorchis species in previous reports. Moreover, we show for the first time that the freshwater shrimp M. lanchesteri serves as a second intermediate host of Isoparorchis sp. and we provide a morphological description and molecular characterization of Isoparorchis sp. metacercariae based on ITS2 sequence data to clarify the status of Isoparorchis sp. in Thailand.
The Italian Arctic expedition 1899–1900: What happened to the first support party?
Authors: Lantz Björn
Published: September 2021

Beginning in the seventeenth century, numerous attempts were made to reach a very high latitude or even the North Pole. One of the more successful of these was the Italian Arctic expedition of 1899–1900, led by Luigi Amedeo di Savoia (Duke of the Abruzzi). Using two successively returning support parties, di Savoia’s second-in-command, Captain Umberto Cagni’s party eventually reached 86°34’N north of their base in the Franz Josef Land archipelago before retreating due to lack of supplies. The second support party also returned safely to the base from 83°16’N. However, the first support party, led by Lieutenant Francesco Querini, disappeared without a trace after returning southwards from 82°32’N. Although previous studies have cited starvation from lack of food supplies or accidents as the potential causes of their disappearance, the extant literature does not provide any deeper analyses to explain these events. This study explores the hypothesis that the first support party in fact turned back from a much more westerly position than they thought. This, in combination with an untimely blizzard that prevented travelling for several days, most likely made it impossible for Querini and his two men to return to base before their limited supplies ran out.
Job quality trajectories among baby-boomers in Germany and their consequences for the motivation to work – results from the lidA cohort study
Authors: Stiller Michael , Garthe Nina , Hasselhorn Hans Martin
Published: September 2021

In light of a large proportion of older workers leaving the German labour market in the near future, policy makers aim to extend working lives to ensure sustainability of the social security system. In this context, safe and healthy working conditions are considered a precondition for encouraging employment participation. To understand better the role of the work environment in pre-retirement years, we draw upon an established model of five job quality profiles for the German ageing workforce. We explored seven-year profile development and linked selected manual and non-manual job quality trajectories to the motivation to work (MTW) using data from the 2011, 2014 and 2018 assessments of the lidA cohort study (valid N = 2,863). We found that older workers shifted to physically less-demanding profiles. Individual profile stability was prevalent among one-third of the workers. In 2018, there was a higher MTW when job quality remained favourable or improved early, while later improvements were associated with lower MTW. Early deterioration of job quality was associated with lower MTW levels among workers with non-manual trajectories only. The results highlight the dynamic job quality situation of the older German workforce and the importance of adopting a person-centred perspective when investigating working conditions and its effects. They further underline the need to consider quality of work when designing and implementing strategies to extend working lives.
CONSUMERS’ UPDATING, POLICY SHOCKS, AND PUBLIC DEBT: AN EMPIRICAL ASSESSMENT OF STATE DEPENDENCIES
Authors: Geiger Martin , Zachariadis Marios
Published: September 2021

We assess the impact of fiscal and monetary policy shocks on US survey-based consumer expectations within states of low and high public debt. Following an unexpected increase in government spending, consumption intentions rise in the low-debt state and fall in the high-debt state. Overall, such a shock has adverse effects on expectations in high-debt states. Similarly, contractionary monetary policy shocks induce pessimistic expectations in the high-debt state but not in the low-debt state. The estimated responses suggest that higher public debt fuels considerations regarding its repayment, giving rise to state dependencies in the updating of expectations in response to both fiscal and monetary policy shocks.
Evaluation of the food environment of public hospitals in a Brazilian metropolis
Authors: José Maria Eduarda Ribeiro , Castro Inês Rugani Ribeiro de , Canella Daniela Silva
Published: September 2021

Objective:

To characterise the food environment of public hospitals in a Brazilian metropolis.

Design:

A cross-sectional study involving the audit of mini-kitchens, non-commercial food services, commercial food services and vending machines within hospitals and interviews with workers and managers. Environmental dimensions assessed included: availability, accessibility, affordability, convenience, nutrition information, promotion and advertising, infrastructure for food and ambience, in addition to decisions-level aspects.

Setting:

Rio de Janeiro, Brazil.

Participants:

24 public hospitals in the municipal health network.

Results:

Of the hospitals assessed, 92·0 % had a non-commercial food service, 87·5 % had mini-kitchens (facilities to consume food taken from home), 37·5 % had commercial food services and 25·0 % had vending machines. Mini-kitchens were available in most but not all hospitals, a key facility given that few commercial or non-commercial food services were open 24 h a day. The food availability in the hospitals surveyed did not promote healthy eating. A wide variety of ultra-processed foods and drinks was found and advertising promoting their consumption, even in non-commercial food services with menus planned by nutritionists. Water filters/fountains were present in around 50 % of mini-kitchens and non-commercial food services but were unavailable in commercial food services. According to workers interviewed, the temperature of the environment was the worst-rated aspect of mini-kitchens, non-commercial food services and commercial food services. Nutrition service managers reported little involvement in producing biddings and proposals for hiring outside companies to run non-commercial food services or commercial food services.

Conclusion:

The food environment of the hospitals studied did not promote healthy eating habits.
PosgenPy: An Automated and Reproducible Approach to Assessing the Validity of Cluster Search Parameters in Atom Probe Tomography Datasets
Authors: Klupś Przemysław , Haley Daniel , London Andrew J , Gardner Hazel , Famelton James , Jenkins Benjamin M , Hyde Jonathan M , Bagot Paul AJ , Moody Michael P
Published: September 2021

One of the main capabilities of atom probe tomography (APT) is the ability to not only identify but also characterize early stages of precipitation at length scales that are not achievable by other techniques. One of the most popular methods to identify nanoscale clustering in APT data, based on the density-based spatial clustering of applications with noise (DBSCAN), is used extensively in many branches of research. However, it is common that not all of the steps leading to the selection of certain parameters used in the analysis are reported. Without knowing the rationale behind parameter selection, it may be difficult to compare cluster parameters obtained by different researchers. In this work, a simple open-source tool, PosgenPy, is used to justify cluster search parameter selection via providing a systematic sweep through parameter values with multiple randomizations to minimize a false-positive cluster ratio. The tool is applied to several different microstructures: a simulated material system and two experimental datasets from a low-alloy steel . The analyses show how values for the various parameters can be selected to ensure that the calculated cluster number density and cluster composition are accurate.
THE BLACK MODEL MINORITY
Authors: Marquez Bayley J.
Published: September 2021

This paper interrogates the fundamental anti-Blackness of model minority discourses and how they are embedded in structures of anti-Blackness and settler colonialism through a genealogical examination of the contradictory history of the “Black model minority” within the Hampton Normal and Agricultural Institute’s Indian Program. This program educated both Black and Indigenous students throughout the late nineteenth and early twentieth centuries and purposefully made racialized comparisons between groups. I read this history through present day scholarship on the model minority myth in relation to anti-Blackness and settler colonialism. I argue that the “Black model minority” at Hampton was predicated on upholding slavery through defining it as an educational project and that slavery and settler colonialism are intimately linked through pedagogy. This narrative of the Black model minority demonstrates that slavery and land dispossession were framed as pedagogic by industrial education institutions. Ultimately, this work questions the idea of “valuing education,” which is present in model minority discourses across many contexts, and how it is complicated by this history.
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β
Authors: Du Fu , Qi Xin , Zhang Aotong , Sui Fanfan , Wang Xuemin , Proud Christopher G. , Lin Cunzhi , Fan Xinglong , Li Jing
Published: September 2021

PD-L1 is abnormally regulated in many cancers and is critical for immune escape. Fully understanding the regulation of PD-L1 expression is vital for improving the clinical efficacy of relevant anticancer agents. TGF-β plays an important role in the low reactivity of PD-1/PD-L1 antibody immunotherapy. However, it is not very clear whether and how TGF-β affects PD-L1 expression. In the present study, we show that TGF-β upregulates the expression of the transcriptional coactivator MRTF-A in non-small-cell lung cancer cells, which subsequently interacts with NF-κB/p65 rather than SRF to facilitate the binding of NF-κB/p65 to the PDL1 promoter, thereby activating the transcription and expression of PD-L1. This leads to the immune escape of NSCLC cells. This process is dependent on the activation of the TGF-β signaling pathway. In vivo, inhibition of MRTF-A effectively suppresses the growth of lung tumor syngrafts with enrichment of NK and T cells in tumor tissue. Our study defines a new signaling pathway that regulates the transcription and expression of PD-L1 upon TGF-β treatment, which may have a significant impact on research into the application of immunotherapy in treating lung cancer.
Evolutionary computational platform for the automatic discovery of nanocarriers for cancer treatment
Authors: Stillman Namid R. , Balaz Igor , Tsompanas Michail-Antisthenis , Kovacevic Marina , Azimi Sepinoud , Lafond Sébastien , Adamatzky Andrew , Hauert Sabine
Published: September 2021

We present the EVONANO platform for the evolution of nanomedicines with application to anti-cancer treatments. Our work aims to decrease both the time and cost required to develop nanoparticle designs. EVONANO includes a simulator to grow tumours, extract representative scenarios, and simulate nanoparticle transport through these scenarios in order to predict nanoparticle distribution. The nanoparticle designs are optimised using machine learning to efficiently find the most effective anti-cancer treatments. We demonstrate EVONANO with two examples optimising the properties of nanoparticles and treatment to selectively kill cancer cells over a range of tumour environments. Our platform shows how in silico models that capture both tumour and tissue-scale dynamics can be combined with machine learning to optimise nanomedicine.
Exploring how microbiome signatures change across inflammatory bowel disease conditions and disease locations
Authors: Amos Gregory C. A. , Sergaki Chrysi , Logan Alastair , Iriarte Rolland , Bannaga Ayman , Chandrapalan Subashini , Wellington Elizabeth M. H. , Rijpkema Sjoerd , Arasaradnam Ramesh P.
Published: September 2021

Understanding the variables that influence microbiome studies is critical for successful translational research. Inflammatory bowel disease (IBD) is a complex group of diseases that can present at multiple locations within the Gastrointestinal tract. Here, using the FAMISHED study cohort, we aimed to investigate the relationship between IBD condition, IBD disease location, and the microbiome. Signatures of the microbiome, including measures of diversity, taxonomy, and functionality, all significantly differed across the three different IBD conditions, Crohn’s disease (CD), ulcerative colitis (UC), and microscopic colitis (MC). Notably, when stratifying by disease location, patients with CD in the terminal ileum were more similar to healthy controls than patients with CD in the small bowel or colon, however no differences were observed at different disease locations across patients with UC. Change in taxonomic composition resulted in changes in function, with CD at each disease location, UC and MC all having unique functional dysbioses. CD patients in particular had deficiencies in Short-Chain Fatty Acid (SCFA) pathways. Our results demonstrate the complex relationship between IBD and the microbiome and highlight the need for consistent strategies for the stratification of clinical cohorts and downstream analysis to ensure results across microbiome studies and clinical trials are comparable.
Vitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen
Authors: Rothen Jean-Pierre , Rutishauser Jonas , Walter Philipp N. , Hersberger Kurt E. , Arnet Isabelle
Published: September 2021

Comparison of several regimens of oral vitamin D including an individually calculated loading regimen with the aim of achieving serum values > 75 nmol/l. Interventional, randomized, 3-arm study in vitamin D-deficient outpatients. Participants were allocated to supplementation of 24,000 IU vitamin D monthly over three months, using either a monthly drinking solution (Vi-De 3) or capsule (D3 VitaCaps), or an individualized loading regimen with the capsules taken weekly. For the loading regimen, the cumulative dose was calculated according to baseline 25-hydroxy-vitamin D (25(OH)D) serum value and body weight. Main inclusion criteria were age ≥ 18 years and 25(OH)D serum concentration < 50 nmol/l. The primary outcome was 25(OH)D serum concentration one week after treatment termination. Secondary endpoints were patient’s preferences and adverse events. Full datasets were obtained from 52 patients. Mean 25(OH)D values were statistically significant higher after a loading regimen compared to a monthly administration of 24,000 IU vitamin D (76.4 ± 15.8 vs 61.4 ± 10.8 nmol/l; p < 0.01). All patients treated with the loading regimen reached sufficient 25(OH)D values > 50 nmol/l. Serum 25(OH)D values > 75 nmol/l were observed more frequently in patients taking the loading regimen (47% vs 11% drinking solution vs 12% capsules). Vitamin D-related adverse effects did not occur in any treatment groups. Capsules were preferred by 88.5% of the patients. Compared to treatments with monthly intake of 24,000 IU vitamin D, the intake of an individually calculated weekly loading regimen was able to raise serum concentrations > 50 nmol/l in all cases within a safe range.