bluuebunny/crossref_metadata_2025 huggingface dataset:
Differing paths to organizational performance: strategic implications of resource transformation and capability reinforcement
Authors: Mathur Manisha
Published: February 2023

Globally, organizations have little insight into mechanisms that enable them to leverage their resources and capabilities successfully. In that endeavor, this study demonstrates that organizations can achieve competitive advantages through resource transformation and capability reinforcement. Using a conceptual framework grounded in the resource-based view and the dynamic capabilities theory in combination with Miles and Snow typology, we show how different types of organizations can succeed in the currently evolving competitive landscape by developing mechanisms that match the strategic performance measures of the organizations, such as return on assets or Tobin'sQ. Notably, analyzing data obtained from 114 firms with seemingly unrelated regression, the findings reveal central roles of alternating mechanisms that drive differential organizational performance and enable the organizations to successfully deploy resources and capabilities.
Distinct brain activity alterations of treatment for bipolar disorders with psychotherapy and drug therapy: activation likelihood estimation meta-analysis
Authors: Luo Jingyi , Yi Pengcheng , Liang Meng , Zhang Shuyu , Tao Qian , Li Ni , Zhang Han , Wen Jialin , Xue Xinrong , Fan Chuan , Li Xiaoming
Published: February 2023

Backgrounds

Many studies suggest that both psychotherapy and drug therapy are effective in the treatment of bipolar disorders (BDs). However, the pathophysiology of both types of intervention has not been established definitively.

Methods

An activation likelihood estimation meta-analysis was performed to identify the distinct brain activity alterations between psychotherapy and drug therapy for the treatment of BDs. Articles were identified by searching databases including PubMed, Embase, Cochrane Library, and Web of Science databases. Eligible studies on BDs were published up until 10 June 2021.

Results

21 studies were included and we conducted a meta-analysis for different therapies and imaging tasks. After receiving psychotherapy, BD patients showed increased activation in the inferior frontal gyrus (IFG) and superior temporal gyrus. While after taking drug therapy, BD patients displayed increased activation in the anterior cingulate cortex, medial frontal gyrus, IFG, and decreased activation in the posterior cingulate cortex. The regions of brain activity changes caused by psychotherapy were mostly focused on the frontal areas, while drug therapy mainly impacted on the limbic areas. Different type of tasks also affected brain regions which were activated.

Conclusions

Our comprehensive meta-analysis indicates that these two treatments might have effect on BD in their own therapeutic modes. Psychotherapy might have a top-down effect, while drug therapy might have a bottom-up effect. This study may contribute to differential diagnosis of BDs and would be helpful to finding more accurate neuroimaging biomarkers for BD treatment.
Existential well-being for the oldest old in nursing homes: a meta-ethnography
Authors: Balkin Emma Jelstrup , Grønkjær Mette , Martinsen Bente , Kymre Ingjerd Gåre , Kollerup Mette Geil
Published: February 2023

Ideas of well-being in old age are often anchored in the successful ageing paradigm, foregrounding independence, activeness and autonomy. However, for those oldest old living in nursing homes, these goals are largely out of reach. In this article, we use the meta-ethnographic method to explore and reinterpret existing findings on the ways in which well-being is experienced (or not) by the oldest old in institutional care settings. We frame our findings in existential well-being theory, which understands wellbeing as a sense of ‘dwelling-mobility’. Our analysis resulted in the following themes: (a) institutionalisation as both restrictive and liberating; (b) reciprocity and mattering: the importance of being seen; (c) the need for kinship and the problem of ruptured sociality; (d) rethinking agency: situated, delegated and supported; and (e) lowered expectations: receiving care is not a passive act. We conclude that while institutional care environments are not always conducive to well-being, this does not have to be so. By shifting our focus from successful ageing ideals onto relationally situated care practices, a possibility for existential well-being opens up, even in situations of decline and care dependency.
Sources of individual differences in the dual language development of heritage bilinguals
Authors: PARADIS Johanne
Published: February 2023

Bilingual children are a more heterogenous group than their monolingual counterparts with respect to the sources of variation in their language learning environments, as well as the wide individual variation in their language abilities. Such heterogeneity in both individual difference factors and language abilities argues for the importance of an individual differences approach in research on bilingual development. The main objective of this article is to provide a review and synthesis of research on the sources of individual differences in the second language (L2) and heritage language (HL) development of child bilinguals. Several child-internal and child-external individual difference factors are discussed with respect to their influence on children’s dual language abilities. In addition, the emergent research on individual differences in bilingual children with developmental language disorder is reviewed. Both the theoretical and applied relevance of individual difference approaches to bilingual development are discussed.
Ontogeny of index-finger pointing
Authors: RÜTHER Johanna , LISZKOWSKI Ulf
Published: February 2023

Index-finger pointing is foundational to language acquisition. Less is known about its emergence. In lab-based monthly longitudinal assessments from 8-13 months (N = 31) the study measured longitudinal predictors of index-finger pointing: parent pointing and infants’ earlier emerging showing, hand-pointing, and point-following. All behaviors increased significantly with age and showed inter-individual stability. At 11 months all behaviors except hand pointing were synchronously interrelated, with no evidence for an earlier synchronous interrelation between behaviors. Caregiver pointing and infants’ earlier behaviors longitudinally predicted the age of emergence of index-finger pointing. An additional cross-sectional comparison of parent pointing at 5 and 7 months (N = 44) showed that significantly fewer caregivers of 5- compared to 7-month-olds pointed for their infants. Findings suggest that pointing emerges as an outcome of social co-construction across the first year of life.
Seroprevalence of COVID-19 infection in a densely populated district in the eastern Democratic Republic of Congo
Authors: Irenge Leonid M. , Bulakali Homer M. , Akonkwa Arthur Irenge , Ambroise Jérôme , Gala Jean-Luc
Published: February 2023

Data on coronavirus disease 2019 (COVID-19) prevalence in the Democratic Republic of Congo are scarce. We conducted a cross-sectional study to determine the seroprevalence of antibodies against anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the slum of Kadutu, city of Bukavu, between June and September 2021. The survey participants were all unvaccinated against SARS-CoV-2. The crude seroprevalence rate was adjusted to the known characteristics of the assay. Participants aged 15–49 years old made up 80% of the population enrolled in the study (n = 507; 319 women and 188 men). The overall crude and adjusted seroprevalence rates of antibodies for COVID-19 were 59.7% (95% CI 55.4–63.9%) and 84.0% (95% CI 76.2–92.4%), respectively. This seroprevalence rate indicates widespread dissemination of SARS-CoV-2 in these communities. COVID-19 symptoms were either absent or mild in more than half of the participants with antibodies for COVID-19 and none of the participants with antibodies for COVID-19 required hospitalisation. These results suggest that SARS-CoV-2 spread did not appear to be associated with severe symptoms in the population of these settlements and that many cases went unreported in these densely populated locations. The relevance of vaccination in these communities should be thoroughly investigated.
Solar Orbiter Data‐Model Comparison in Venus' Induced Magnetotail
Authors: Stergiopoulou Katerina , Jarvinen Riku , Andrews David J. , Edberg Niklas J. T. , Dimmock Andrew P. , Kallio Esa , Persson Moa , Khotyaintsev Yuri V.
Published: February 2023

We investigate the structure of the Venusian magnetotail utilizing magnetic field and electron density measurements that cover a wide range of distances from the planet, from the first two Solar Orbiter Venus flybys. We examine the magnetic field components along the spacecraft trajectory up to 80 Venus radii down the tail. Even though the magnetic field behavior differs considerably between the two cases, we see extended electron density enhancements covering distances greater than ∼20 RV in both flybys. We compare the magnetic field measurements with a global hybrid model of the induced magnetosphere and magnetotail of Venus, to examine to what degree the observations can be understood with the simulation. The model upstream conditions are stationary and the solution encloses a large volume of 83 RV × 60 RV × 60 RV in which we look for spatial magnetic field and plasma variations. We rotate the simulation solution to describe different stationary upstream IMF clock angle cases with a 10° step and find the clock angle for which the agreement between observations and model is maximized along Solar Orbiter's trajectory in 1‐min steps. We find that in both flybys there is better agreement with the observations when we rotate the model for some intervals, while there are parts that cannot be well reproduced by the model irrespective of how we vary the IMF clock angle, suggesting the presence of non‐stationary features in  the Venus‐solar wind interaction not accounted for in the hybrid model.
High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight
Authors: Korgan Austin C. , Oliveira-Abreu Klausen , Wei Wei , Martin Sophie L. A. , Bridges Zoey J. D. , Leal-Cardoso José Henrique , Kaczorowski Catherine C. , O’Connell Kristen M. S.
Published: February 2023

Background/Objective

As the obesity epidemic continues, the understanding of macronutrient influence on central nervous system function is critical for understanding diet-induced obesity and potential therapeutics, particularly in light of the increased sugar content in processed foods. Previous research showed mixed effects of sucrose feeding on body weight gain but has yet to reveal insight into the impact of sucrose on hypothalamic functioning. Here, we explore the impact of liquid sucrose feeding for 12 weeks on body weight, body composition, caloric intake, and hypothalamic AgRP neuronal function and synaptic plasticity.

Methods

Patch-clamp electrophysiology of hypothalamic AgRP neurons, metabolic phenotyping and food intake were performed on C57BL/6J mice.

Results

While mice given sugar-sweetened water do not gain significant weight, they do show subtle differences in body composition and caloric intake. When given sugar-sweetened water, mice show similar alterations to AgRP neuronal excitability as in high-fat diet obese models. Increased sugar consumption also primes mice for increased caloric intake and weight gain when given access to a HFD.

Conclusions

Our results show that elevated sucrose consumption increased activity of AgRP neurons and altered synaptic excitability. This may contribute to obesity in mice and humans with access to more palatable (HFD) diets.
Reusability of Germany´s total diet study food list upon availability of new food consumption data—comparison of three update strategies
Authors: Kolbaum Anna Elena , Ptok Sebastian , Jung Christian , Libuda Lars , Lindtner Oliver
Published: February 2023

Background

The German total diet study (TDS)—BfR MEAL Study—established its food list in 2016 based on food consumption data of children (0.5–<5 years) and adults (14–80 years). The list consists of 356 foods selected for analysis in order to ensure ≥90% coverage of the diet. Recently, new food consumption data for children (0.5–<6 and 6–<12 years) in Germany became available, which raised the opportunity to evaluate the applicability of the MEAL food list 2016 on new data.

Objective

We tested the hypotheses that the MEAL food list 2016 also covers ≥90% of the diet of the new collected food consumption data, and that the selection of foods from younger children and adults was sufficient to also cover the middle age group (6–<12 years). Strategies for updating the existing food list were assessed.

Methods

Three approaches evaluated the reusability and potential adjustment strategies of the existing food list. Approach 1 applied the existing food list to new food consumption data. Approach 2 allowed the extension of the existing food list to improve coverage of food consumption. Approach 3 set up a new food list based on the new data.

Results

The MEAL food list 2016 covered 94% of the overall diet of the new collected food consumption data. The diet of the middle age group was sufficiently covered with 91%. However, coverage on main food group or population subgroup level was <90% in some cases. Approach 3 most accurately identified relevant modifications to the existing food list. 94% of the MEAL food list 2016 could be re-used and 51 new foods were identified as potentially relevant.

Significance

The results suggest that a high investment in the coverage of a TDS food list will lower the effort and the resources to keep data updated in the long-term.

Impact

There is no established approach to update a TDS food list. This study provides comparative approaches to handle newly collected food consumption data for follow-on TDS activities. The results provide useful information for institutions planning or updating a TDS. Furthermore, new food consumption data for children in Germany recently became available and are here presented for the first time.
SARS-CoV-2 infection induces persistent adipose tissue damage in aged golden Syrian hamsters
Authors: Bogard Gemma , Barthelemy Johanna , Hantute-Ghesquier Aline , Sencio Valentin , Brito-Rodrigues Patricia , Séron Karin , Robil Cyril , Flourens Anne , Pinet Florence , Eberlé Delphine , Trottein François , Duterque-Coquillaud Martine , Wolowczuk Isabelle
Published: February 2023

Coronavirus disease 2019 (COVID-19, caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)) is primarily a respiratory illness. However, various extrapulmonary manifestations have been reported in patients with severe forms of COVID-19. Notably, SARS-CoV-2 was shown to directly trigger white adipose tissue (WAT) dysfunction, which in turn drives insulin resistance, dyslipidemia, and other adverse outcomes in patients with COVID-19. Although advanced age is the greatest risk factor for COVID-19 severity, published data on the impact of SARS-CoV-2 infection on WAT in aged individuals are scarce. Here, we characterized the response of subcutaneous and visceral WAT depots to SARS-CoV-2 infection in young adult and aged golden hamsters. In both age groups, infection was associated with a decrease in adipocyte size in the two WAT depots; this effect was partly due to changes in tissue’s lipid metabolism and persisted for longer in aged hamsters than in young-adult hamsters. In contrast, only the subcutaneous WAT depot contained crown-like structures (CLSs) in which dead adipocytes were surrounded by SARS-CoV-2-infected macrophages, some of them forming syncytial multinucleated cells. Importantly, older age predisposed to a unique manifestation of viral disease in the subcutaneous WAT depot during SARS-CoV-2 infection; the persistence of very large CLSs was indicative of an age-associated defect in the clearance of dead adipocytes by macrophages. Moreover, we uncovered age-related differences in plasma lipid profiles during SARS-CoV-2 infection. These data suggest that the WAT’s abnormal response to SARS-CoV-2 infection may contribute to the greater severity of COVID-19 observed in elderly patients.
The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention
Authors: Cambier Seppe , Gouwy Mieke , Proost Paul
Published: February 2023

Chemokines are an indispensable component of our immune system through the regulation of directional migration and activation of leukocytes. CXCL8 is the most potent human neutrophil-attracting chemokine and plays crucial roles in the response to infection and tissue injury. CXCL8 activity inherently depends on interaction with the human CXC chemokine receptors CXCR1 and CXCR2, the atypical chemokine receptor ACKR1, and glycosaminoglycans. Furthermore, (hetero)dimerization and tight regulation of transcription and translation, as well as post-translational modifications further fine-tune the spatial and temporal activity of CXCL8 in the context of inflammatory diseases and cancer. The CXCL8 interaction with receptors and glycosaminoglycans is therefore a promising target for therapy, as illustrated by multiple ongoing clinical trials. CXCL8-mediated neutrophil mobilization to blood is directly opposed by CXCL12, which retains leukocytes in bone marrow. CXCL12 is primarily a homeostatic chemokine that induces migration and activation of hematopoietic progenitor cells, endothelial cells, and several leukocytes through interaction with CXCR4, ACKR1, and ACKR3. Thereby, it is an essential player in the regulation of embryogenesis, hematopoiesis, and angiogenesis. However, CXCL12 can also exert inflammatory functions, as illustrated by its pivotal role in a growing list of pathologies and its synergy with CXCL8 and other chemokines to induce leukocyte chemotaxis. Here, we review the plethora of information on the CXCL8 structure, interaction with receptors and glycosaminoglycans, different levels of activity regulation, role in homeostasis and disease, and therapeutic prospects. Finally, we discuss recent research on CXCL12 biochemistry and biology and its role in pathology and pharmacology.
Silver nanoparticle enhanced metal-organic matrix with interface-engineering for efficient photocatalytic hydrogen evolution
Authors: Liu Yannan , Liu Cheng-Hao , Debnath Tushar , Wang Yong , Pohl Darius , Besteiro Lucas V. , Meira Debora Motta , Huang Shengyun , Yang Fan , Rellinghaus Bernd , Chaker Mohamed , Perepichka Dmytro F. , Ma Dongling
Published: February 2023

Integrating plasmonic nanoparticles into the photoactive metal-organic matrix is highly desirable due to the plasmonic near field enhancement, complementary light absorption, and accelerated separation of photogenerated charge carriers at the junction interface. The construction of a well-defined, intimate interface is vital for efficient charge carrier separation, however, it remains a challenge in synthesis. Here we synthesize a junction bearing intimate interface, composed of plasmonic Ag nanoparticles and matrix with silver node via a facile one-step approach. The plasmonic effect of Ag nanoparticles on the matrix is visualized through electron energy loss mapping. Moreover, charge carrier transfer from the plasmonic nanoparticles to the matrix is verified through ultrafast transient absorption spectroscopy and in-situ photoelectron spectroscopy. The system delivers highly efficient visible-light photocatalytic H2 generation, surpassing most reported metal-organic framework-based photocatalytic systems. This work sheds light on effective electronic and energy bridging between plasmonic nanoparticles and organic semiconductors.
Modulating stereoselectivity in allylic C(sp3)-H bond arylations via nickel and photoredox catalysis
Authors: Huang Long , Szewczyk Marcin , Kancherla Rajesh , Maity Bholanath , Zhu Chen , Cavallo Luigi , Rueping Magnus
Published: February 2023

While significant progress has been made in developing selective C-H bond cross-couplings in the field of radical chemistry, the site and stereoselectivity remain a long-standing challenge. Here, we present the successful development of stereodivergent allylic C(sp3)-H bond arylations through a systematic investigation of the direction and degree of stereoselectivity in the cross-coupling process. In contrast to the signature photosensitized geometrical isomerization of alkenes, the catalytic reaction demonstrates the feasibility of switching the C-C double bond stereoselectivity by means of ligand control as well as steric and electronic effects. Computational studies explain the stereochemical outcome and indicate that excitation of a Ni-allyl complex from singlet to a triplet state results in a spontaneous change of the allyl group coordination and that the subsequent isomerization can be directed by the choice of the ligand to achieveE/Zselectivity.
The importance of the interface for picosecond spin pumping in antiferromagnet-heavy metal heterostructures
Authors: Kholid Farhan Nur , Hamara Dominik , Hamdan Ahmad Faisal Bin , Nava Antonio Guillermo , Bowen Richard , Petit Dorothée , Cowburn Russell , Pisarev Roman V. , Bossini Davide , Barker Joseph , Ciccarelli Chiara
Published: February 2023

Interfaces in heavy metal (HM) - antiferromagnetic insulator (AFI) heterostructures have recently become highly investigated and debated systems in the effort to create spintronic devices that function at terahertz frequencies. Such heterostructures have great technological potential because AFIs can generate sub-picosecond spin currents which the HMs can convert into charge signals. In this work we demonstrate an optically induced picosecond spin transfer at the interface between AFIs and Pt using time-domain THz emission spectroscopy. We select two antiferromagnets in the same family of fluoride cubic perovskites, KCoF3 and KNiF3, whose magnon frequencies at the centre of the Brillouin zone differ by an order of magnitude. By studying their behaviour with temperature, we correlate changes in the spin transfer efficiency across the interface to the opening of a gap in the magnon density of states below the Néel temperature. Our observations are reproduced in a model based on the spin exchange between the localized electrons in the antiferromagnet and the free electrons in Pt. Through this comparative study of selected materials, we are able to shine light on the microscopy of spin transfer at picosecond timescales between antiferromagnets and heavy metals and identify a key figure of merit for its efficiency: the magnon gap. Our results are important for progressing in the fundamental understanding of the highly discussed physics of the HM/AFI interfaces, which is the necessary cornerstone for the designing of femtosecond antiferromagnetic spintronics devices with optimized characteristics.
Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions
Authors: Chen Nai-Chi , Wang Chun-Hsiung , Yoshimura Masato , Yeh Yi-Qi , Guan Hong-Hsiang , Chuankhayan Phimonphan , Lin Chien-Chih , Lin Pei-Ju , Huang Yen-Chieh , Wakatsuki Soichi , Ho Meng-Chiao , Chen Chun-Jung
Published: February 2023

Understanding the structural diversity of honeybee-infecting viruses is critical to maintain pollinator health and manage the spread of diseases in ecology and agriculture. We determine cryo-EM structures of T = 4 and T = 3 capsids of virus-like particles (VLPs) of Lake Sinai virus (LSV) 2 and delta-N48 LSV1, belonging to tetraviruses, at resolutions of 2.3–2.6 Å in various pH environments. Structural analysis shows that the LSV2 capsid protein (CP) structural features, particularly the protruding domain and C-arm, differ from those of other tetraviruses. The anchor loop on the central β-barrel domain interacts with the neighboring subunit to stabilize homo-trimeric capsomeres during assembly. Delta-N48 LSV1 CP interacts with ssRNA via the rigid helix α1’, α1’–α1 loop, β-barrel domain, and C-arm. Cryo-EM reconstructions, combined with X-ray crystallographic and small-angle scattering analyses, indicate that pH affects capsid conformations by regulating reversible dynamic particle motions and sizes of LSV2 VLPs. C-arms exist in all LSV2 and delta-N48 LSV1 VLPs across varied pH conditions, indicating that autoproteolysis cleavage is not required for LSV maturation. The observed linear domino-scaffold structures of various lengths, made up of trapezoid-shape capsomeres, provide a basis for icosahedral T = 4 and T = 3 architecture assemblies. These findings advance understanding of honeybee-infecting viruses that can cause Colony Collapse Disorder.
Measurement of the axial vector form factor from antineutrino–proton scattering
Authors: Cai T. , Moore M. L. , Olivier A. , Akhter S. , Dar Z. Ahmad , Ansari V. , Ascencio M. V. , Bashyal A. , Bercellie A. , Betancourt M. , Bodek A. , Bonilla J. L. , Bravar A. , Budd H. , Caceres G. , Carneiro M. F. , Díaz G. A. , da Motta H. , Felix J. , Fields L. , Filkins A. , Fine R. , Gago A. M. , Gallagher H. , Gilligan S. M. , Gran R. , Granados E. , Harris D. A. , Henry S. , Jena D. , Jena S. , Kleykamp J. , Klustová A. , Kordosky M. , Last D. , Le T. , Lozano A. , Lu X.-G. , Maher E. , Manly S. , Mann W. A. , Mauger C. , McFarland K. S. , Messerly B. , Miller J. , Moreno O. , Morfín J. G. , Naples D. , Nelson J. K. , Nguyen C. , Paolone V. , Perdue G. N. , Plows K.-J. , Ramírez M. A. , Ransome R. D. , Ray H. , Ruterbories D. , Schellman H. , Salinas C. J. Solano , Su H. , Sultana M. , Syrotenko V. S. , Valencia E. , Vaughan N. H. , Waldron A. V. , Wascko M. O. , Wret C. , Yaeggy B. , Zazueta L.
Published: February 2023

Scattering of high energy particles from nucleons probes their structure, as was done in the experiments that established the non-zero size of the proton using electron beams1. The use of charged leptons as scattering probes enables measuring the distribution of electric charges, which is encoded in the vector form factors of the nucleon2. Scattering weakly interacting neutrinos gives the opportunity to measure both vector and axial vector form factors of the nucleon, providing an additional, complementary probe of their structure. The nucleon transition axial form factor, FA, can be measured from neutrino scattering from free nucleons, νμn → μ−p and $${\bar{\nu }}_{\mu }p\to {\mu }^{+}n$$

ν

¯

μ

p
→

μ

+

n

, as a function of the negative four-momentum transfer squared (Q2). Up to now, FA(Q2) has been extracted from the bound nucleons in neutrino–deuterium scattering3–9, which requires uncertain nuclear corrections10. Here we report the first high-statistics measurement, to our knowledge, of the $${\bar{\nu }}_{\mu }\,p\to {\mu }^{+}n$$

ν

¯

μ

p
→

μ

+

n

cross-section from the hydrogen atom, using the plastic scintillator target of the MINERvA11 experiment, extracting FA from free proton targets and measuring the nucleon axial charge radius, rA, to be 0.73 ± 0.17 fm. The antineutrino–hydrogen scattering presented here can access the axial form factor without the need for nuclear theory corrections, and enables direct comparisons with the increasingly precise lattice quantum chromodynamics computations12–15. Finally, the tools developed for this analysis and the result presented are substantial advancements in our capabilities to understand the nucleon structure in the weak sector, and also help the current and future neutrino oscillation experiments16–20 to better constrain neutrino interaction models.
Field-linked resonances of polar molecules
Authors: Chen Xing-Yan , Schindewolf Andreas , Eppelt Sebastian , Bause Roman , Duda Marcel , Biswas Shrestha , Karman Tijs , Hilker Timon , Bloch Immanuel , Luo Xin-Yu
Published: February 2023

Scattering resonances are an essential tool for controlling the interactions of ultracold atoms and molecules. However, conventional Feshbach scattering resonances1, which have been extensively studied in various platforms1–7, are not expected to exist in most ultracold polar molecules because of the fast loss that occurs when two molecules approach at a close distance8–10. Here we demonstrate a new type of scattering resonance that is universal for a wide range of polar molecules. The so-called field-linked resonances11–14 occur in the scattering of microwave-dressed molecules because of stable macroscopic tetramer states in the intermolecular potential. We identify two resonances between ultracold ground-state sodium–potassium molecules and use the microwave frequencies and polarizations to tune the inelastic collision rate by three orders of magnitude, from the unitary limit to well below the universal regime. The field-linked resonance provides a tuning knob to independently control the elastic contact interaction and the dipole–dipole interaction, which we observe as a modification in the thermalization rate. Our result provides a general strategy for resonant scattering between ultracold polar molecules, which paves the way for realizing dipolar superfluids15 and molecular supersolids16, as well as assembling ultracold polyatomic molecules.
Single-cell spatial landscapes of the lung tumour immune microenvironment
Authors: Sorin Mark , Rezanejad Morteza , Karimi Elham , Fiset Benoit , Desharnais Lysanne , Perus Lucas J. M. , Milette Simon , Yu Miranda W. , Maritan Sarah M. , Doré Samuel , Pichette Émilie , Enlow William , Gagné Andréanne , Wei Yuhong , Orain Michele , Manem Venkata S. K. , Rayes Roni , Siegel Peter M. , Camilleri-Broët Sophie , Fiset Pierre Olivier , Desmeules Patrice , Spicer Jonathan D. , Quail Daniela F. , Joubert Philippe , Walsh Logan A.
Published: February 2023

Single-cell technologies have revealed the complexity of the tumour immune microenvironment with unparalleled resolution1–9. Most clinical strategies rely on histopathological stratification of tumour subtypes, yet the spatial context of single-cell phenotypes within these stratified subgroups is poorly understood. Here we apply imaging mass cytometry to characterize the tumour and immunological landscape of samples from 416 patients with lung adenocarcinoma across five histological patterns. We resolve more than 1.6 million cells, enabling spatial analysis of immune lineages and activation states with distinct clinical correlates, including survival. Using deep learning, we can predict with high accuracy those patients who will progress after surgery using a single 1-mm2 tumour core, which could be informative for clinical management following surgical resection. Our dataset represents a valuable resource for the non-small cell lung cancer research community and exemplifies the utility of spatial resolution within single-cell analyses. This study also highlights how artificial intelligence can improve our understanding of microenvironmental features that underlie cancer progression and may influence future clinical practice.
Single-cell spatial immune landscapes of primary and metastatic brain tumours
Authors: Karimi Elham , Yu Miranda W. , Maritan Sarah M. , Perus Lucas J. M. , Rezanejad Morteza , Sorin Mark , Dankner Matthew , Fallah Parvaneh , Doré Samuel , Zuo Dongmei , Fiset Benoit , Kloosterman Daan J. , Ramsay LeeAnn , Wei Yuhong , Lam Stephanie , Alsajjan Roa , Watson Ian R. , Roldan Urgoiti Gloria , Park Morag , Brandsma Dieta , Senger Donna L. , Chan Jennifer A. , Akkari Leila , Petrecca Kevin , Guiot Marie-Christine , Siegel Peter M. , Quail Daniela F. , Walsh Logan A.
Published: February 2023

Single-cell technologies have enabled the characterization of the tumour microenvironment at unprecedented depth and have revealed vast cellular diversity among tumour cells and their niche. Anti-tumour immunity relies on cell–cell relationships within the tumour microenvironment1,2, yet many single-cell studies lack spatial context and rely on dissociated tissues3. Here we applied imaging mass cytometry to characterize the immunological landscape of 139 high-grade glioma and 46 brain metastasis tumours from patients. Single-cell analysis of more than 1.1 million cells across 389 high-dimensional histopathology images enabled the spatial resolution of immune lineages and activation states, revealing differences in immune landscapes between primary tumours and brain metastases from diverse solid cancers. These analyses revealed cellular neighbourhoods associated with survival in patients with glioblastoma, which we leveraged to identify a unique population of myeloperoxidase (MPO)-positive macrophages associated with long-term survival. Our findings provide insight into the biology of primary and metastatic brain tumours, reinforcing the value of integrating spatial resolution to single-cell datasets to dissect the microenvironmental contexture of cancer.
IL-6/ERK signaling pathway participates in type I IFN-programmed, unconventional M2-like macrophage polarization
Authors: Yang Limin , Guo Panpan , Wang Pei , Wang Wei , Liu Jianghuai
Published: February 2023

Type I interferons (IFN-Is) have been harnessed for cancer therapies due to their immunostimulatory functions. However, certain tumor-tolerating activities by IFN-Is also exist, and may potentially thwart their therapeutic effects. In this respect, our previous studies have demonstrated a monocyte-orchestrated, IFN-I-to-IL-4 cytokine axis, which can subsequently drive M2-skewed pro-tumoral polarization of macrophages. Whether other IFN-dependent signals may also contribute to such an unconventional circumstance of M2-like macrophage skewing remain unexplored. Herein, we first unveil IL-6 as another ligand that participates in IFN-dependent induction of a typical M2 marker (ARG1) in transitional monocytes. Indeed, IL-6 significantly promotes IL-4-dependent induction of a major group of prominent M2 markers in mouse bone marrow-derived macrophages (BMDMs) and human peripheral blood-derived macrophages, while it alone does not engage marked increases of these markers. Such a pattern of regulation is confirmed globally by RNAseq analyses in BMDMs, which in turn suggests an association of IL-6-amplified subset of M2 genes with the ERK1/2 signaling pathway. Interestingly, pharmacological experiments establish the role of SHP2-ERK cascade in mediating IL-6’s enhancement effect on these M2 targets. Similar approaches also validate the involvement of IL-6/ERK signaling in promoting the IFN-dependent, unconventional M2-skewing phenotype in transitional monocytes. Furthermore, an inhibitor of ERK signaling cooperates with an IFN-I inducer to enable a greater antitumor effect, which correlates with suppression of treatment-elicited ARG1. The present work establishes a role of IL-6/ERK signaling in promoting M2-like macrophage polarization, and suggests this axis as a potential therapeutic target for combination with IFN-I-based cancer treatments.
Physical evidence of meminductance in a passive, two-terminal circuit element
Authors: Dinavahi Abhiram , Yamamoto Alexandre , Harris H. Rusty
Published: February 2023

The first intentional memristor was physically realized in 2008 and the memcapacitor in 2019, but the realization of a meminductor has not yet been conclusively reported. In this paper, the first physical evidence of meminductance is shown in a two-terminal passive system comprised primarily of an electromagnet interacting with a pair of permanent magnets. The role of series resistance as a parasitic component which obscures the identification of potential meminductive behavior in physical systems is discussed in detail. Understanding and removing parasitic resistance as a “resistive flux” is explored thoroughly, providing a methodology for extracting meminductance from such a system. The rationale behind the origin of meminductance is explained from a generalized perspective, providing the groundwork that indicates this particular element is a realization of a fundamental circuit element. The element realized herein is shown to bear the three required and necessary fingerprints of a meminductor, and its place on the periodic table of circuit elements is discussed by extending the genealogy of memristors to meminductors.
Toxic Ag+ detection based on Au@Ag core shell nanostructure formation using Tannic acid assisted synthesis of Pullulan stabilized gold nanoparticles
Authors: Jayeoye Titilope John , Supachettapun Chamaiporn , Muangsin Nongnuj
Published: February 2023

Herein, a sensitive colorimetric detection strategy is proposed for Ag+ detection based on the use of environmentally friendly synthesis of gold nanoparticles (AuNPs), at room temperature, using (tannic acid, TA), as the reductant and pullulan (PUL) as stabilizing agent. The colloidal solution (TA/PUL-AuNPs), at the optimal synthesis conditions, showed maximum absorbance at 529 nm with a berry red color. TEM and FESEM validated that the particles are spherical and monodispersed, while other characterization results elucidated the role of pullulan in the nano-synthesis. Ag+ addition to the probe (TA/PUL-AuNPs), pH 11, resulted in naked-eye color changes, owing to Au@Ag core shell nanostructure formation. Further, the added Ag+ is reduced to AgNPs, on the surface of the TA/PUL-AuNPs probe. A hypsochromic shift in the absorption maximum, from 529 to 409 nm was observed, while (AAg+-Abl)@409 nm exhibited linearity with Ag+ concentrations, from 0.100 to 150 µM. The estimated limit of detection was 30.8 nM, which is far lower than the acceptable limit of 0.930 µM from the regulatory agency. The TA/PUL-AuNPs probe was further tested for Ag+ detection in lake water samples, and it displayed satisfactory detection performances for real sample applications.
Bagarius bagarius, and Eichhornia crassipes are suitable bioindicators of heavy metal pollution, toxicity, and risk assessment
Authors: Mahamood Mohammad , Khan Farmanur Rahman , Zahir Farhana , Javed Mehjbeen , Alhewairini Saleh S.
Published: February 2023

Water quality index (WQI) of Narora channel and health of endemic fish Bagarius bagarius and plant Eichhornia crassipes, district Bulandshahar, Uttar Pradesh, India were studied. Among the physicochemical properties of water, pH, D.O, Cr, Fe, Ni, and Cd were above the recommended standards. These factors lead to high WQI (4124.83), indicating poor quality and not suitable for drinking and domestic usage. In fish tissues, the highest metal load was reported in the liver (58.29) and the lowest in the kidney (33.73). Heavy metals also cause a lowering of condition indices. As expected, decreased serum protein (− 63.41%) and liver glycogen (− 79.10%) were recorded in the exposed fish. However, blood glucose (47.22%) and serum glycogen (74.69%) showed elevation. In the plant, roots (21.50) contained the highest, and leaves (16.87) had the lowest heavy metal load. Bioaccumulation factor (BAF) > 1, indicates hyperaccumulation of all metals. E. crassipes roots showed the highest translocation factor (TF) > 1 for Ni (1.57) and Zn (1.30). The high mobility factor (MF) reflected the suitability of E. crassipes for phytoextraction of Mn, Cd, Zn, Fe, Ni, and Cu. Moreover, Bagarius sp. consumption could not pose any non-cancer risk. Although, lower cancer risk can be expected from Ni and Cr.
Quantitative multimodal imaging of extensive macular atrophy with pseudodrusen and geographic atrophy with diffuse trickling pattern
Authors: Antropoli Alessio , Arrigo Alessandro , Bianco Lorenzo , Berni Alessandro , Lamberto La Franca , Saladino Andrea , Bandello Francesco , Battaglia Parodi Maurizio
Published: February 2023

To compare clinical and imaging characteristics of extensive macular atrophy with pseudodrusen-like appearance (EMAP) versus diffuse-trickling geographic atrophy (DTGA) and non-diffuse-trickling geographic atrophy (nDTGA) phenotypes of age-related macular degeneration. Prospective, observational study performed in the Ophthalmology Department of IRCCS San Raffaele Hospital between January 2015 and January 2021. Patients examination included fundus autofluorescence (FAF) and optical coherence tomography at baseline and follow-up visits. We measured subfoveal choroidal thickness (SCT), Sattler/choroid ratio (SCR), choroidal vascularity index and ellipsoid zone disruption distance on OCT scans. We calculated progression rates and circularity of the atrophic lesions on FAF images. These variables were compared between the three groups and correlations with progression rates and visual acuity were assessed. Sixty-three eyes from 63 patients were included: 18 with EMAP, 18 with DTGA and 27 with nDTGA. Mean follow-up was 3.73 ± 2.12 years. EMAP and DTGA shared a faster progression, lower circularity and SCR, and higher EZ disruption distance than nDTGA, while SCT and CVI were similar between the three groups. Baseline circularity and SCR correlated with progression rates. EMAP and DTGA show similar OCT and FAF characteristics, which differ from nDTGA.
Surface-dependent quenching of Qdot emission can be a new tool for high resolution measurements
Authors: Okura Kaoru , Tatsumi Hitoshi
Published: February 2023

Single quantum dots (Qdots) are often used in the field of single-molecule imaging. Qdots are sensitive to changes in the physical interactions between the Qdots and the surrounding materials. However, the spectral changes in a single Qdot emission have not been studied in detail. Low-temperature plasma treatment of glass surfaces reduced the intensity of the 655 nm emission peak of Qdot655 on glass surfaces, but did not significantly change the intensity of the 580 nm emission. Silanization of the glass surface increases the thickness of the silane layer, and the 655 nm emission peak increased. When single Qdots on the untreated glass were imaged, plasma treatment decreased the intensity of red emission and increased yellow emission. When Qdots were brought close to the glass surface in the range of 28–0 nm, the red emission intensity decreased and the yellow emission intensity increased slightly. When single actin filaments were labeled with Qdots, fluctuations of the yellow and red emission of the Qdot were detected, which reflected the very small distance changes. Our results indicate that the local interaction of Qdots with the glass surface improves the spatial and temporal resolution of optical measurements of biomolecules labeled with Qdots.
Efficacy of combined transbronchial lung cryobiopsy and conventional forceps biopsy for lung malignancies: a prospective cohort study
Authors: Kinoshita Kohei , Morikawa Kei , Tsuruoka Hajime , Chosokabe Motohiro , Kida Hirotaka , Handa Hiroshi , Inoue Takeo , Miyazawa Tomoyuki , Saji Hisashi , Mineshita Masamichi
Published: February 2023

There are few prospective reports of transbronchial lung cryobiopsy (TBLC) for malignant tumors in combination with forceps biopsy. We investigated the clinical parameters in which TBLC is superior to forceps biopsy. This is a prospective cohort study to analyse the efficacy of TBLC for suspected malignancy. TBLC was performed after brushing cytology and forceps biopsy, and the diagnostic yield for TBLC, brushing cytology, and forceps biopsy were examined. Adverse events were defined as those requiring additional procedures. Next-generation sequencing (NGS) analysis was performed in each case of non-small cell lung cancer. Of the 100 patients, malignancy was confirmed in 94 cases. The diagnostic yield for TBLC/forceps biopsy/brushing cytology was 86/81/82% respectively, while the diagnostic yield for all procedures combined was 94%. There was no significant difference in the diagnostic yield between TBLC and forceps biopsy. When comparing the biopsy site, the diagnostic yield for TBLC at the lower lobe was significantly higher than forceps biopsy (P < 0.01). Endobronchial ultrasonography imaging using a guide-sheath did not significantly differ in the diagnostic yield of TBLC. The success rate of NGS for TBLC specimens was 100% (26 cases). Adverse events included two cases of severe bleeding. TBLC of peripheral lesions may improve the diagnostic yield when combined with forceps biopsy and brushing cytology. The diagnostic yield of TBLC was higher at the lower lobes. Furthermore, TBLC provided sufficient specimen quality for NGS.
Unveiling the complex structure-property correlation of defects in 2D materials based on high throughput datasets
Authors: Huang Pengru , Lukin Ruslan , Faleev Maxim , Kazeev Nikita , Al-Maeeni Abdalaziz Rashid , Andreeva Daria V. , Ustyuzhanin Andrey , Tormasov Alexander , Castro Neto A. H. , Novoselov Kostya S.
Published: February 2023

Modification of physical properties of materials and design of materials with on-demand characteristics is at the heart of modern technology. Rare application relies on pure materials—most devices and technologies require careful design of materials properties through alloying, creating heterostructures of composites, or controllable introduction of defects. At the same time, such designer materials are notoriously difficult to model. Thus, it is very tempting to apply machine learning methods to such systems. Unfortunately, there is only a handful of machine learning-friendly material databases available these days. We develop a platform for easy implementation of machine learning techniques to materials design and populate it with datasets on pristine and defected materials. Here we introduce the 2D Material Defect (2DMD) datasets that include defect properties of represented 2D materials such as MoS2, WSe2, hBN, GaSe, InSe, and black phosphorous, calculated using DFT. Our study provides a data-driven physical understanding of complex behaviors of defect properties in 2D materials, holding promise for a guide to the development of efficient machine learning models. In addition, with the increasing enrollment of datasets, our database could provide a platform for designing materials with predetermined properties.
Predicting chemical exfoliation: fundamental insights into the synthesis of MXenes
Authors: Björk Jonas , Halim Joseph , Zhou Jie , Rosen Johanna
Published: February 2023

The factors controlling the top-down synthesis of MXenes, by selectively removing the A elements from parent MAX phases, is still under debate. In particular, understanding why some MAX phases can be used for creating MXenes, while others cannot, is of immense interest and would greatly support computational screening and identification of new two-dimensional materials that could also be created by chemical exfoliation. Here we computationally study the etching of MAX phases in hydrofluoric acid, considering the complete exfoliation process and competing processes during the initial steps of the synthesis. The results are compared to experiments and MAX phases successfully converted to MXenes, as well as so far unsuccessful attempts, including previously unpublished experimental data, rationalizing why some MAX phases are exfoliable while others are not. Our results provide an improved understanding of the synthesis of MXenes under acid conditions, anticipated to be vital for our ability to discover novel two-dimensional materials.
When the dynamical writing of coupled memories with reinforcement learning meets physical bounds
Authors: Jules Théo , Michel Laura , Douin Adèle , Lechenault Frédéric
Published: February 2023

Bits manipulation in traditional memory writing is commonly done through quasi-static operations. While simple to model, this method is known to reduce memory capacity. We demonstrate how a reinforcement learning agent can exploit the dynamical response of a simple multi-bit mechanical system to restore its memory. To do so, we introduce a model framework consisting of a chain of bi-stable springs manipulated on one end by the external action of the agent. We show that the agent learns how to reach all available states for three springs, even though some states are not reachable through adiabatic manipulation, and that training is significantly improved using transfer learning techniques. Interestingly, the agent also points to an optimal system design by taking advantage of the underlying physics. Indeed, the control time exhibits a non-monotonic dependence on the internal dissipation, reaching a minimum at a cross-over shown to verify a mechanically motivated scaling relation.