bluuebunny/crossref_metadata_2025 huggingface dataset:
The Expression of Oct3/4A mRNA and Not Its Isoforms is Upregulated by the HPV16 E7 Oncoprotein
Authors: Gómez-Gómez Yazmín , Organista-Nava Jorge , Clemente-Periván Sayuri Itzel , Lagunas-Martinez Alfredo , Salmerón-Bárcenas Eric Genaro , Villanueva-Morales Daniel , Ayala-Reyna Dania Yahaira , Alarcón-Romero Luz del Carmen , Ortiz-Ortiz Julio , Jiménez-López Marco Antonio , Illades-Aguiar Berenice
Published: November 2021

Oct3/4 a transcription factor is involved in maintaining the characteristics of cancer stem cells. Oct3/4 can be expressed differentially with respect to the progression of CC. In addition, Oct3/4 can give rise to three isoforms by alternative splicing of the mRNA Oct3/4A, Oct3/4B and Oct3/4B1. The aim of this study was to evaluate the mRNA expression from Oct3/4A, Oct3/4B and Oct3/4B1 in low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), cervical cancer (CC) samples, and measure the effect of the HPV16 E7 oncoprotein on the mRNA expression from Oct3/4 isoforms in the C-33 A cell line. The expression levels of Oct3/4A, Oct3/4B and Oct3/4B1 mRNA were analyzed by reverse transcription quantitative polymerase chain reaction (RT-qPCR) in patients with LSILs, HSILs and CC. Additionally, C-33 A cells that expressed the HPV16 E7 oncoprotein were established to evaluate the effect of E7 on the expression of Oct3/4 mRNA isoforms. Oct3/4A (p=0.02), Oct3/4B (p=0. 001) and Oct3/4B1 (p<0. 0001) expression is significantly higher in patients with LSIL, HSIL and CC than in woman with non-IL. In the C-33 A cell line, the expression of Oct3/4A mRNA in the presence of the E7 oncoprotein increased compared to that in nontransfected C-33 A cells. Oct3/4B and Oct3/4B1 mRNA were expressed at similar levels among the different groups. These data indicate that only the mRNA of Oct3/4A is upregulated by the HPV16 E7 oncoprotein.
Program Characteristics of Cardiothoracic Surgery Departments Versus Divisions
Authors: Soler Lisa Marie , Lopez Raymond A. , Hornbuckle Kyle J , Dabal Robert J , Chen Herbert , Xie Rongbing , Vardas Panos N.
Published: November 2021

Background:The organizational structure of cardiothoracic surgery practices varies among different programs throughout the United States (U.S.). We aimed to investigate the characteristics of the top ranked programs within the specialty and the surgeons practicing within each.Methods: The top 50 hospitals for adult cardiology and heart surgery were identified using the US News and World Report 2019-20 ranking. There were 590 hospitals reported on, with 50 top rated programs. Data was collected from each hospital’s website, analyses conducted using SAS 9.4 with statistical significance set at p < 0.05. Results:When comparing cardiothoracic surgery program organizational structures, 21 of the top 50 ranked programs were departments and 24 were divisions within their respective Department of Surgery. Mean number of surgeons was 11 with no statistical difference when analyzed by division versus department. Overall, 9% of practicing cardiothoracic surgeons were female. Between programs that are a department versus division, general thoracic surgery was included in 58% of divisions and 52% of departments (p = ns). Among programs that were departments, approximately 6% of surgeons had attained a Ph.D., while in divisions approximately 4% of surgeons had attained a Ph.D. Conclusions:The top 50 Cardiothoracic Surgery programs in the U.S. have approximately the same number of surgeons within the group and are organized similarly. This study group had a slightly higher percentage of female surgeons than previously noted in cardiothoracic surgery, with general thoracic surgery trending toward higher gender diversity. The presence of physician scientists was low, though similar amongst the study groups.
DrugDevCovid19: An Atlas of Anti-COVID-19 Compounds Derived By Computer-Aided Drug Design
Authors: Liu Yang , Gan Jianhong , Wang Rongqi , Yang Xiaocong , Xiao Zhixiong , Cao Yang
Published: November 2021

Since the outbreak of SARS-CoV-2, numerous compounds against COVID-19 have been derived by computer-aided drug design (CADD) studies. They are valuable resources for the development of COVID-19 therapeutics. In this work, we reviewed these studies and analyzed 779 compounds against 16 target proteins from 181 CADD publications. We performed unified docking simulations and neck-to-neck comparison with the solved co-crystal structures. We computed their chemical features and classified these compounds aiming to provide insights for subsequent drug design. Through detailed analyses, we recommended a batch of compounds that are worth further study. Moreover, we organized all the abundant data and constructed a freely available database, DrugDevCovid19 (http://clab.labshare.cn/covid/php/index.php), to facilitate the development of COVID-19 therapeutics.
Rapid increase of SpO2 on room air for 34 severe COVID-19 patients after ivermectin-based combination treatment: 55-62% normalization within 12-24 hours
Authors: Stone Jacqueline C , Ndarukwa Pisirai , Scheim David E , Dancis Barry M , Dancis Jerry , Gill Martin G , Aldous Colleen
Published: November 2021

Background. The emergence of COVID-19 in March 2020 challenged Zimbabwe to mount a response with limited medical facilities and therapeutic options. Ivermectin (IVM) had by then been safely used to treat a variety of human diseases affecting millions, as noted by the Nobel Committee in awarding its 2015 prize for medicine. Based upon early clinical indications of efficacy against COVID-19, IVM-based combination treatments were deployed to treat this infection in Zimbabwe.Methods. Data were retrospectively analyzed for 34 severe COVID-19 patients treated with IVM-based combination therapy between August 2020 and May 2021, for whom pre- and post-treatment SpO2 values were all recorded on room air. Mortality and deterioration outcomes were also analyzed for a larger set of 92 severe COVID-19 patients receiving IVM-based treatment.Results: For the 34-patient SpO2 tracking series, all but two patients had significantly increased SpO2 values after the first IVM dose, and all patients recovered. Mean increases in SpO2 as percentages of full normalization to SpO2=97 were 55.1% at +12 hours and 62.3% at +24 hours post-treatment. These results paralleled similar sharp increases in SpO2, all on room air, for a series of 24 RT-qPCR confirmed, mostly severe COVID-19 patients in the USA (California) who were given IVM combination treatment, all of whom recovered. For 19 of those patients having SpO2 ≤ 90 prior to IVM, the mean SpO2 normalization at +24 hours post-treatment was 65.2% as calculated from the SpO2 values reported. For our larger series of 92 severe COVID-19 patients in Zimbabwe, median age 53, only two died and two more deteriorated prior to recovery, far less than a predicted 7 deaths and 17 deteriorations for the demographics and risk factors of these patients.Conclusions. The rapid, marked increases in SpO2 for both the Zimbabwe and California patients stand in sharp contrast to the decline in SpO2 and associated pulmonary function following onset of moderate or severe COVID-19 symptoms under standard care. These rapid SpO2 increases and low mortality rates support extended deployment of IVM treatment for COVID-19, complementary to immunizations for prevention.
Home Care Practices of Cancer Caregivers and the Effect of Perceived Social Support on Care Burden
Authors: Ulgen Tuba , Uğur Özlem
Published: November 2021

Purpose: Caregivers have to manage tasks at home such as providing management of the patient’s follow-up. Social support is known to have protective effects, especially for family members and caregivers for cancer patients. The aim of this study is to investigate the effect of care on home care and perceived social support on cancer burden. Methods: A descriptive and cross-sectional study. This study was conducted in the Chemotherapy Day Treatment Unit of a University Research and Application Hospital. a 222 patients were included in the study. In this study, Caregiver and Patient Identification Form, Caregiver's Home Care Practices Questionnaire Form, Zarit Caregiver Burden Scale, Perceived Multidimensional Social Support Scale, Karnofsky Performance Scales were used. The data of the study were collected by face-to-face interviews conducted with the caregivers. Results: In our research the social support level was found to be moderately adequate and had a mild maintenance burden. In our study, when the relationship between the multidimensional perceived social support scale scores and the Zarit care load scale scores is examined it was found that there was a significant relation between the perceived social support total scores of caregivers and the care burden scores in a weak and negative way (p <.01). Conclusion: It has been determined that the caregivers of cancer patients have taken care of their home care practices and the perceived lack of social support.
The Influence of Visual Objects and Music on Anxiety Levels of Breast Cancer Patients Scheduled to Experience Chemotherapy for the First Time: A Prospective Randomized Clinical Study
Authors: iriagac Yakup , Cavdar Eyyup , Karaboyun Kubilay , Avci Okan , Tuna Nehir , Seber Erdogan Selcuk
Published: November 2021

ObjectiveTo investigate the influence of music together with attractive visual objects as an ambiance in the waiting room on anxiety levels of breast cancer patients scheduled to receive chemotherapy in outpatient setting for the first time.Material and MethodBreast cancer patients planned to receive adjuvant or neoadjuvant chemotherapy for the first time between November 1st, 2020 and July 31st, 2021 were included. Two designs, including a standard waiting room (StWR) and an intervention waiting room (IWR) that was created by adding music and visual objects to the standard room were constructed. These 2 designs were repeated sequentially in monthly periods and a total of 104 patients with 52 in each group were randomized. The State Trait Anxiety Inventory (STAI) and Hospital Anxiety and Depression Scale (HADs) were used for assessments. Results of the patients in StWR and IWR groups were compared.ResultsBoth HADs anxiety and STAI-state anxiety scale scores were lower in patients who waited in IWR compared to those who waited in StWR (p=0.041, p=0.012, respectively). In patients in the IWR group, mean heart rate was lower by 7.6 bpm (p=0.009). No difference was found between the groups with regard to HADs depression score and STAI-trait anxiety score (p=0.305, p=0.535, respectively). For all patients, HADs anxiety scale (r=0.400, p=<0.001) and STAI-state anxiety scale (r=0.475, p=<0.001) scores increased as the waiting time increased.Discussion and ConclusionThe present study is the first to investigate the influence of adding music together with attractive visual objects to the standard ambiance of the chemotherapy waiting room on anxiety levels of breast cancer patients. We propose that introduction of paintings, artificial plants, and music to the ambiance of the waiting room has a significantly positive effect on alleviating anxiety levels of cancer patients waiting for chemotherapy.
The Pacific Decadal Precession and its Relationship to Tropical Pacific Decadal Variability in CMIP6 Models
Authors: Rogers Matthew H. , Furtado Jason , Anderson Bruce
Published: November 2021

Persistent, multi-year shifts in atmospheric circulations and their associated influence on regional climates have profound impacts on physical, biological, and socioeconomic systems. The Pacific Decadal Precession (PDP), an atmospheric mode of variability consisting of a lower tropospheric height dipole which rotates counterclockwise over several years in the North Pacific, describes a series of such shifts in atmospheric circulations. One phase of the PDP, the north-south (N-S) phase, is hypothesized to be partially driven by central tropical Pacific (CP) sea surface temperature (SST) variability, but robust assessment of this dynamical connection in climate models remains to be done. In this study, we investigate this hypothesis with analyses in both reanalysis and selected models from the Coupled Model Intercomparison Project Phase 6 (CMIP6) archive. We show that the emergence of the N-S phase is both related to and influenced by tropical Pacific decadal SST variability, specifically variability associated with CP El Niño-Southern Oscillation (ENSO) events. When examining the CMIP6 model output, we find that most models cannot recover the characteristic cyclonic precession of the dipoles of the PDP, instead featuring only amplitude and sign changes of the N-S phase, Moreover, the models do not replicate the dynamical connections between the tropical Pacific and this North Pacific mode. Our results suggest that primary reasons for this inconsistency are that models inaccurately simulate both the SST pattern associated with the PDP, shared low-frequency power associated with CP ENSO events, and incorrect Rossby wavetrains emanating from the tropical Pacific into the North Pacific on quasi-decadal timescales. Taken together, our analyses offer another benchmark by which to test the fidelity of the climate model simulations in capturing Pacific decadal climate variability in order to improve decadal-to-centennial climate projections.
In diffuse intrinsic pontine gliomas, non-coding RNA expression is significantly varied dependent on overall survival
Authors: Rucha  , S Vijay
Published: November 2021

Diffuse intrinsic pontine glioma is a kind of pediatric brain cancer that kills 99 percent of patients within five years and for which there are no conventional chemotherapies. It is crucial for new treatments to comprehend the cancer's transcriptional activity. Using a published dataset, we compared the transcriptomes of tumors from patients who lived longer or less than six months. Among the genes whose expression changed most, we observed that numerous microRNAs and snoRNAs were present. The publication's findings are the first evidence of variable levels of non-coding RNA expression in diffuse intrinsic pontine glioma.
Design and Optimization of a Novel-Herbosomal Loaded PEG-Poloxamer Topical Formulation For the Treatment of Cold Injuries: A Quality By Design Approach
Authors: Yadav Renu Bala , Pathak Dharam Pal , Varshney Rajeev , Arora Rajesh
Published: November 2021

Cold injury/injuries can range from minor chilblain to extreme form of frostbite. Cold injuries are pathologically a combination of ice crystal formation in tissue with inflammation, thrombosis and ischemia to extremities, necessitating limb amputation in extreme cases due to tissue necrosis. Less severe forms of cold injuries can be managed by gentle rewarming of limb and avoiding exposure to cold leading to favorable outcomes, however severe forms of frostbite are a cause of major concern to patients as well as the treating physician. Due to lack of effective pre-treatment modalities and paucity of research in prophylaxis and therapeutics of cold injuries, we have developed a novel-herbosomal loaded PEG-Poloxamer topical formulation (n-HPTF) by Quality by Designed approach, incorporating natural ingredients which are having potential therapeutic effect for the treatment of cold injury in a form of a novel-lipid vesicles (herbosomes) loaded in polymers (PEG-3350 and Poloxamer-188) resulting excellent occlusive barrier and thus promote rapid healing. Optimized novel-herbosomes showed entrapment efficiency > 90% and < 300 nm mean particle size and in-vitro drug permeation of about 2 µg/cm2 followed by Higuchi’s release kinetic. Skin irritancy study on female Sprague Dawley rats showed no edema or erythema. In-vivo bio-efficacy study was performed and found significantly good at p-value < 0.05 when compared to the standard treatment groups.
Corruption Control, Renewable-led Energy Transition and Carbon Emissions: Empirical Evidence from Panel Data of Multi-countries
Authors: Wang Yongpei , Yang Jieru
Published: November 2021

This paper focuses on the carbon emission reduction effect of anti-corruption mediated by renewable-led energy transition based on the panel data of 98 countries from 1996 to 2015. Since the mediation model is estimated by estimating a series of multiple regression equations, the total, direct and indirect effects can be separated out to clarify the conduction path between corruption control, renewable energy and carbon emissions. Owing to confirmation of the Sobel-Goodman mediation tests, renewable energy acts as a significant mediator through which corruption control contributes to emission reduction, regardless of the indicator is total carbon emissions, carbon emissions per capita or carbon emission intensity. For policymakers and regulators, there needs to be more emphasis on eliminating corruption in the increased penetration of renewable energy and not being seduced by traditional lobbyists. Particularly for developing countries, the effective way to reduce emissions is to remove institutional barriers in priority areas including the energy and resources sectors to cleaner-oriented energy transition.
Research On the Multiscale Characteristics of the Early Spring Temperature and Response To Climate Indices Over the Past 179 Years in the Qinling Mountains
Authors: Zhang Chenhua , Wang Jiachuan , Li Shuheng , Hou Li
Published: November 2021

Examination of the periodic differences in temperature in the Qinling Mountains at different time scales is highly important in research on the long-term evolution of the regional climate system and ecological environment. Based on February-April temperature data from 1835 to 2013 obtained at 27 weather stations in the Qinling Mountains reconstructed through tree rings, the multiscale characteristics of the early spring temperature time series on the southern and northern slopes of the Qinling Mountains and the response to climate signals were analyzed. The results indicate that the early spring temperature in the Qinling Mountains exhibits significant periodic characteristics on multiple time scales. Reconstruction at the different time scales reveals that the interannual scale change in the temperature variation on the northern slope of the Qinling Mountains plays a decisive role. The temperature on the northern slope exhibits a higher amplitude at the interannual and interdecadal scales than does that on the southern slope, and temporal differences occur at the quasi-century scale. The temperature achieves the strongest correlation with the original Atlantic Multidecadal Oscillation (AMO) sequence during the entire study period. In addition, the different time scales reveal that there exists a significant response relationship between the temperature at the interannual scale and the May sea temperature in the NINO3.4 area, which lags by one year. At the different time scales and various time ranges, the Qinling early spring temperature responds differently to the climate signals, which is an important factor leading to a lower correlation during the entire study period.
Factors Influencing Health-Related Quality of Life of People who Eat Alone
Authors: Lee Eunmi , Han Kuem Sun , Cho Jeonghyun , Kim Taeyoun
Published: November 2021

Background: The Andersen model was utilized to identify differences in the predictors of quality of life (QOL) between people who eat alone and those who do not. Methods: Data of 5,432 adults who responded to a question about having company for meals from the 2016 KNHANES were analyzed. Using the Andersen model, the parameters were classified into predisposing factors, enabling factors, need factors, and health behaviors; differences in the influences of each parameter category on QOL, depending on company during meals, were analyzed using logistic regression. Results: Individuals who ate alone included higher percentages of older women living alone, people with no medical aid or private insurance membership, low education and income, more chronic diseases, poorer perceived health, activity restrictions and unmet health care needs, and smoking and drinking, and lower health examination rates. Differences in the predictors of each domain of health-related QOL (HRQOL) were analyzed according to the absence of company during meals. Perceived health status was a predictor of all domains of HRQOL regardless of eating alone or not; age, activity restrictions, sex, and number of chronic diseases predicted two to four domains of QOL. Factors predicting QOL only among individuals who ate alone were sex (mobility, self-care, and usual activities), number of chronic diseases and health examination (pain/discomfort), and private insurance membership (anxiety/depression). Conclusion: The results verify the potential of using the Andersen model for measuring HRQOL. These findings highlight the need for tailored welfare services, social policies, and programs for people who eat without company.
Comprehensive Modeling and Molecular Docking of Phosphodiesterase Inhibitors
Authors: khosravi zahra , baher elham , gharaghani sajad , ehsani salma
Published: November 2021

In the present study, the biological activity of some pharmaceutical molecules was investigated and predicted by using quantitative structure-activity relationship (QSAR) studies and molecular docking. The aim of this study is to apply QSAR and molecular docking methods to predict and calculate the half maximal inhibitory concentration (IC50) of phosphodiesterase (PDE) 10A. To apply QSAR method at first multiple linear regression (MLR), genetic algorithm (GA), and successive projection algorithm (SPA) were used to select the best descriptors related to PDE 10A inhibitory activity. The selected descriptors were then applied as inputs to construct MLR and a non-linear support vector machine (SVM). Also we used molecular docking method to extract the descriptors and then by using MLR and SVM methods a linear and non-linear models developed respectively. Consequently, a comparison of the results of QSAR and docking study indicated that the non-linear SVM-SPA2 in QSAR study and SVM-MLR in molecular docking study had a much better prediction power than the other models. Finally, the Y-scrambling and cross-validation tests were used to evaluate the validity of the obtained model and the results of these tests indicates that the model is appropriate for using in prediction.
Relationship Among Health-Related Quality of Life and Autosomal Ancestry, Clinical and Socioeconomic Factors In Type 1 Diabetes in an Admixed Brazilian Population.
Authors: Azulay Rossana Sousa , Lago Débora , Santos Glaucia Abreu Silva , Tavares Maria da Gloria , Rodrigues Vandilson , Magalhães Marcelo , Reis Roberta Ferreira , Nunes Nayara , de Almeida Ana Gregória Ferreira Pereira , Sá Adriana Guimarães , Nascimento Gilvan , Damianse Sabrina , Rocha Viviane , Silva Dayse Aparecida , Gomes Marília Brito , Faria Manuel
Published: November 2021

BACKGROUND: Type 1 diabetes is a chronic disease of an autoimmune character that affects the quality of life of patients in different degrees. Race and socioeconomic differences directly affect glycemic control. This study aimed to evaluate the Health-related quality of life (HRQoL) of Type 1 diabetes mellitus (T1D) patients an admixed Brazilian population, and to identify the variables influencing this condition.METHODS: This research is a cross-sectional study conducted at the University Hospital-Federal University of Maranhão Endocrinology Service with 152 T1D patients between 2017 and 2018. HRQoL information was obtained from two self-completed questionnaires: Short Form-6 dimensions and EuroQol-5 dimensions with visual analog scale. For inference of autosomal ancestry, a panel of 46 autosomal informational insertion/deletion ancestry markers (AIM–Indels) was used. Demographic information, socioeconomic data, presence of chronic complications, glycemic control level, and type of treatment were collected.RESULTS: In the study, the patients who had good HRQoL were characterized as follows: male, under 18 years old, single, with average of 11 years of schooling, had health insurance, with less than 5 years of diagnosis, practiced physical activity, experienced no hypoglycemia in the last 30 days, reported no chronic complications (retinopathy and nephropathy), participant in several group educational activities, used analogous insulin, monitored blood glucose, showed maximum treatment adherence, and came from the secondary service. Autosomal ancestry and self-reported color/race did not show influence on HRQoL indexes.CONCLUSION: Our study is the first to measure the HRQoL, autosomal ancestry and recognize the impact of T1D on patients' lives in the State of Maranhão, Northeast of Brazil. The results validate the need to provide T1D patients with continuous training on self-management and self-monitoring, seeking better results in metabolic control and consequently, in the prevention of acute and chronic complications to generate positive impacts on the quality of life of this population. In addition, reinforcing physical activity at each appointment should be part of the health team’s routine. We understand that ethnicity in a highly mixed population like ours did not influence the quality of life of these patients.
Comparative Physiological and Transcriptomic Analysis Reveal MdWRKY75 Associated With Sucrose Accumulation in Postharvest Apples With Bitter Pits
Authors: Sun Chen , Zhang Weiwei , Qu Haiyong , Yan Longfei , Li Lixia , Zhao Yuqi , Yang Hongqiang , Zhang Hua , yao gaifang , Hu Kangdi
Published: November 2021

Background: Calcium (Ca) deficiency can cause apple bitter pits, reduce the quality and shelf life. WRKY Transcription factors play essential role in plant response to multiple diseases. However, the underlying mechanisms causing bitter pits in apple fruit due to Ca deficiency during storage is extremely limited. Results: In the present study, the nutritional metabolites and reactive oxygen species (ROS) were compared in Ca-deficient and healthy apple fruit (CK) during storage. Results showed that Ca-deficient apples sustained significantly higher production of ROS, PPO activity, flavonoids, total phenol, total soluble solids (TSS), and sucrose contents, but the contents of Ca, H2O2, titratable acids (TA), glucose and fructose were significantly lower than those of CK during storage. Principal component analysis (PCA) showed that TSS, •O2−­, PPO, MDA and Ca were the main factors, and TSS had a positive correlation with sucrose. Furthermore, transcriptome analysis revealed that WRKYs were co-expressed with sucrose metabolism-related enzymes (SWEETs, SS, SPS). RT-qPCR and correlation analysis indicated that MdWRKY75 were significantly positively correlated with MdSWEET1. Moreover, transient overexpression of MdWRKY75 could significantly increase the sucrose content and promote the expression of MdSWEET1 in apple fruit.Conclusions: Calcium deficiency could decrease antioxidant capacity, accelerate nutritional metabolism and up-regulate the expression of WRKYs in apple with bitter pits. Overexpression of MdWRKY75 significantly increased sucrose accumulation and the expression of MdSWEET1. These findings further strengthened knowledge of the basic molecular mechanisms in calcium-deficient apple flesh and contributed to improving the nutritional quality of apple fruit.
Neuroligins Facilitate The Development of Bone Cancer Pain via Regulating Synaptic Transmission
Authors: Xie Xianqiao , Li Yang , Su Shanchun , Li Xiaohui , Xu Xueqin , Sun Dongsheng , Gao Yan , Peng Minjing , Wu Yanqiong , Ke Changbin
Published: November 2021

Background
The underlying mechanism of chronic pain involves the plasticity in synaptic receptors and neurotransmitters. This study aimed to investigate potential roles of neuroligins (NLs) within the spinal dorsal horn of rats in a newly established bone cancer pain (BCP) model.
Methods
Using our rat BCP model, we assessed pain hypersensitivity over time. Quantitative real-time polymerase chain reaction and Western blot analysis were performed to investigate NL expression, and NLs were overexpressed in the rat spinal cord using lentiviral vectors. Immunofluorescence staining and whole-cell patch-clamp recordings were deployed to investigate the role of NLs in the development of BCP.
Results
We observed reduced expression levels of NL1 and NL2, but not NL3, within the rat spinal cord, which were found to be associated with and essential for the development of BCP in our model. Accordingly, NL1 or NL2 overexpression in the spinal cord alleviated mechanical hypersensitivity of rats. Electrophysiological experiments indicated that NL1 and NL2 are involved in BCP via regulating γ-aminobutyric acid-ergic interneuronal synapses and the activity of glutamatergic interneuronal synapses, respectively.
Conclusions
Our observations unravel the role of NLs in cancer-related chronic pain and further suggest that inhibitory mechanisms are central features of BCP in the spinal dorsal horn. These results provide a new perspective and basis for subsequent studies elucidating the onset and progression of BCP.
Multi-criteria approach to selecting sites for solar-diesel hybrid systems
Authors: Tremyasov V. A. , Grigorieva O. A. , Kenden K. V.
Published: November 2021

The paper aims to develop a site selection procedure for solar-diesel hybrid systems using a multi-criteria performance analysis of site options. The site selection process using this multi-criteria approach was carried out on the example of Kungurtug rural settlement (Tyva Republic). The area surrounding this settlement was analyzed, revealing four possible sites for a solar-diesel system. For evaluating the performance of these site options, the following criteria were adopted: ease of installation and maintenance of the solar-diesel hybrid system; surface topography and soil quality; convenience of the photovoltaic cell layout; environmental impact of the solar-diesel hybrid system; opportunities for further expansion of the system; orientation potential of the photovoltaic cell. In order to assess the significance of the concordance coefficient, the distribution quantile was determined, amounting to 16.2. For 5 degrees of freedom and a significance level of 0.05, the table value of the concordance coefficient amounted to 16.2. Since the distribution quantile is greater than the table value, the concordance coefficient can be considered significant (95% confidence level), indicating agreement between expert opinions. Experts ranked the site options to obtain relative performance estimates for the criteria; numeric indicators were converted into the relative estimates using linear transformation formulas. The multi-criteria performance estimates of the possible options were calculated for arithmetic mean and harmonic convolutions. After comparing the site options for the solar-diesel system, the second variant characterized by the highest criterion scores was selected for Kungurtug settlement. As a result, a site selection procedure for the elements of solar-diesel hybrid systems was developed using the theory of multi-criteria optimization and the method of expert evaluations, allowing a set of technical, economic, climatic, and environmental criteria to be taken into account.
Implementation of digital automated control systems at electrolytic copper refining plants in Vietnam
Authors: Bazhin V. Yu. , Gorlenkov D. V. , Nguyen Huu Hoang , Nikitina L. N.
Published: November 2021

The work aims to develop digital control and management systems of copper electrolytic refining processes when addressing energy efficiency issues. Thermal imaging scanners can be used to monitor the process state of an electrolytic cell. In this regard, the experience in the automation and control systems of OJSC Novgorod Metallurgical Plant was considered. Mathematical research methods and a stochastic model developed in the MatLab software were used. This model was applied at the Lao Cai copper-smelting plant (Vietnam). The proposed algorithm is based on the temperature variation in electrolyte depending on the heating of cathode and anode sections during short circuits due to dendritic growth, as well as process disturbance time. The algorithm was developed using the Visual BasicScript programming languages. The temperature rise in short circuit areas was recorded using a thermal imaging scanner immediately after the colour change of the cathode surface. It was shown that the duration of a short circuit depends on the amount of sludge deposited in an electrolytic cell. The sludge formed following the destruction of intergrown dendrites contains precious metals. The developed measures, along with those of digitisation, are necessary for effective management, taking into account the functional and kinetic characteristics of the copper refining process. The proposed solutions and control algorithms will allow remote access systems with augmented reality elements when creating a digital twin. This will reduce the specific power consumption by 20 –25% while decreasing the number of electrode short circuits. Controlling the composition and level of electrolyte and sludge will reduce material losses and maintain the concentration of noble metals in the electrolyte. To improve the control quality of automation during the electrolytic production of cathode copper, a number of technical measures were proposed that provide additional points of control to expand the process database. Furthermore, the proportion of manual periodic measurements of process parameters is reduced.
Cooked sausage enriched with essential nutrients for the gastrointestinal diet
Authors: Sadovoy Vladimir , Shchedrina Tatiana , Trubina Irina , Morgunova Anna , Franko Evgenia
Published: November 2021

Introduction. People with gastrointestinal disorders should have a sparing diet with a balanced chemical and amino acid composition including all essential components. Based on formulations of meat products, we identified a number of essential nutritional components that could improve the diet for gastrointestinal pathologies. In this study, we aimed to develop a formulation for cooked sausage enriched with deficient essential nutrients.

Study objects and methods. Our study object was cooked sausage. First, we analyzed the diet for people with gastrointestinal disorders. Then, we formulated a meat-based product (cooked sausage), determined its chemical and amino acid compositions, as well as vitamin and mineral contents, and assessed the balance of amino acids. Finally, we evaluated the biological value and safety of the formulated sausage on laboratory mice.

Results and discussion. The chemical and amino acid compositions of a daily gastrointestinal diet in medical institutions revealed a deficiency of some water-soluble vitamins, vitamin A, calcium, magnesium, and iron, as well as an imbalance of amino acids. To replenish the deficiency, we formulated a meat-based product composed of trimmed beef and pork, beef liver, egg mix, food gelatin, chitosan succinate, rice flour, and soy fortifier. The product was classified as a meat and cereal cooked sausage of grade B, in which most amino acids were used for anabolic purposes. Its daily portion of 100 g eliminated the deficiency of potassium and iron, almost completely replenished magnesium, calcium, and vitamin A, as well as reduced the deficiency of dietary fiber by 4.8 g. The cytological studies of the blood of laboratory animals, whose basic diet contained the formulated sausage, proved its high biological value and safety.

Conclusion. We found that the formulated meat and cereal sausage can be included in the diet for patients with gastrointestinal diseases and used in medical institutions to eliminate the deficiency of essential nutrients.
Bodies of Transitional Power at the Final Stage of the Civil War
Authors:   Don State Technical University, Morozova Olga M. , Troshina Tatyana I. ,   Northern (Arctic) Federal University named after M.V. Lomonosov,   Northern State Medical University
Published: November 2021

The article is grounded on the research based on a large set of documents stored in the central and regional archives of the Russian Federation and neighboring countries. The authors have formulated a research question concerning identification of the common features in the process of restoration of the Soviet power on the outskirts of the country during the last stage of the Civil War. The article draws on the material spanning a short period between the retreat of the whites (in the territory of Arkhangelsk province, the Don and Tersk regions, Kuban, Dagestan) and liquidation of governing bodies of the Azerbaijan Democratic Republic and entrance of the Red Army units. If before January-February 1920, the “whites” retreated with battles, then a preventive retreat ensued, and a regime of interstate power was established in the territory they left behind. The article reveals two scenarios on the eve of the reunification of the peripheral territories with the central Bolshevik power. It was quite rare that the area was abandoned without power and order. Usually, the consolidated democratic society either intercepted power from the weakened hands of the white administration or took over the reins of power from the command of the withdrawing White army in an organized manner. Temporary transitional authorities usually included representatives of socialist parties, non-partisan public, and trade unions. But in practice, this process had a distinct regional specificity influenced by the local palette of political forces, in the configuration that had developed before the Civil War. This phenomenon was very poorly reflected in the synchronous historical sources, so along with such miraculously preserved separate documents, personal evidence collected during the early Soviet memorial campaigns formed the basis for the study.
Khyadag and Zunii Gol: Animal Art and the Bronze to Iron Age Transition in Northern Mongolia
Authors:   Smithsonian Institution, Arctic Studies Center, Fitzhugh William W. , Bayarsaikhan Jamsranjav ,   National Museum of Mongolia
Published: November 2021

The Late Bronze Age Mongolian culture known for its memorial deer stones and khirigsuur burials, the Deer Stone-Khirigsuur complex (hereafter DSK) dating to 1300–700 BCE, displays persistence over several hundred years. Radiocarbon dates from hearths and horse remains associated with these sites show little change in architecture, ritual practice, and iconography, giving the impression of an unchanging mortuary cultural regime. New research demonstrates that deer stones are memorials to recently deceased leaders that display distinctive features of personal identification within the unifying framework of an over-arching religious theme represented by deer-bird iconography. Despite continuity, the DSK complex is not monolithic. This paper presents evidence for regional cultural and chronological variation in deer stone art and ceremonial activity based on research at the Khyadag and Zunii Gol sites in northcentral Mongolia. Areal excavation, detailed survey, and recording of deer stone art revealed the presence at Khyadag of a new class of miniature deer stones and evidence of copper smelting, and at Zunii Gol — an unusual khirigsuur associated with a deer stone carrying elements of Scytho-Saka animal style art. These data indicate geographic and chronological overlap in V. V. Volkov’s deer stone types and changes in deer stone art and khirigsuur ritual in the later period of the DSK complex. In the future, emphasis needs to be given to broad excavation strategies that explore the contextual history of individual DSK sites, dating of Volkov’s Type II and III deer stones, and regional comparisons with Xinjiang, Baikal, and the Mongolian and Gornyi Altai.
The Problem of Harmonizing the Economic Interests of the USSR and the Socialist Countries. The Сase of Soviet-Polish Trade and Financial Relations (1958–1964)
Authors:   Chelyabinsk State University, Popov A. A.
Published: November 2021

Soviet trade with Eastern European countries was one of the main forms of economic interaction within the socialist camp. The problem of imbalances in this trade traditionally has been associated with the politicization of intra-bloc relations. However, when harmonizing the interests of the USSR and the socialist interests vis-à-vis long-term trade agreements, economic motives were of great importance. This article discusses the process of harmonizing economic interests, using the case of Soviet-Polish trade relations in 1958–1964. This research based on archival documents from the Department of the Central Committee of the CPSU for Economic Cooperation with the Socialist Countries (in RGANI) and declassified documents from the special fund for the State Planning Commission of RGAE. The analysis shows that contradictions in trade issues provoked a discussion of a wider range of issues: military supplies, credit debt, and transit tariffs for the two countries. Moreover, each of the parties was guided by its own economic interests and rarely made concessions for political reasons. The Soviet government in 1958-1964 made a number of supply concessions, agreed to revise transit tariffs, and incurred part of the costs of maintaining the stability of intra-block trade in the distribution system. There was a change in the structure of Soviet-Polish trade, which significantly reduced the passive trade balance for Polish People’s Republic (RPL). Nevertheless, in accordance with Soviet calculations, after all these changes, trade with RPL and other socialist countries was profitable for the USSR.
Russian Lacquer Crafts During the Great Patriotic War
Authors:   St. Petersburg State University, Lavrov D. E.
Published: November 2021

The history of The Great Patriotic War, which was the greatest test for Russia in the 20th century and whose 75th anniversary was celebrated in 2020, contains many topics that have not been well studied. One such topic is the activity of Russian folk crafts during wartime, among which the lacquered miniatures of Palekh, Mstyora, Kholui, and Fedoskino occupy a special place. This article provides one of the first complex studies of the economic, social, and artistic activities of all four centers of Russian lacquers during the war. In addition to information about the contribution of artists and residents of these villages to victory, the article reveals the main events and results of the development of Russian lacquer crafts during the war. These include exhibition activity and work of local art schools, the activities of artists in propaganda, and lacquered miniatures. Further, the article explores the state purchase orders and work of miniaturists for private purchases, the field of state regulation in folk art, and the loss of life suffered by villages. Special attention is paid to gender-related processes in Russian crafts, as well as support measures that the Soviet state provided to folk art during the war. The author concludes that the Great Patriotic War, despite losses and difficulties, became a time of development for the lacquer crafts in Russia, ensuring their subsequent development in the post-war years.
Searching for the “Strong Hand”: The Revolutionary Crisis in Russia in 1917 and the French Assessments on its Termination
Authors:   Moscow State Institute (University) of International Relations, Magadeev I. E.
Published: November 2021

This article explores how French diplomatic and military representatives in Russia perceived the growing revolutionary crisis of 1917 and what means they proposed to terminate it. Though the French perceptions of the Russian revolution are rather well researched, scholars paid attention chiefly to French estimates linked to the international and strategic situation of Russia and not to the interior processes in this country. Exploring these questions allows us to widen our understanding of the international context of the Russian revolution and to throw new light on the events of 1917 through the lens of French perceptions. This article is based on the underresearched documents from the Diplomatic archives of the French Foreign Ministry and from the National Archives of France. After having analyzed dispatches of French diplomats and military representatives in Russia during 1917, the author discerns two interlinked tendencies of these observers. First, they notice growing disorganization and “anarchy” in Russia; second, they tried to find and to support political forces in Russia that were capable of restoring “order” and to continue the fight in the war. However, inside this conceptual “frame” there were significant controversies. Conservative French diplomats and the military initially put their hopes in Alexander Kerensky and then in General Lavr Kornilov. After being disappointed in both, they tried to restore “discipline” and to conserve the Eastern front by external forces. Left French observers initially had more enthusiasm for the February revolution and even after the evaporation of these hopes warned Paris not to support counterrevolutionary forces in Russia. In many aspects, discussions about Russian policy of France in 1917 foreshadowed the dilemmas in the relations of Paris with “Reds” and “Whites” during the intervention and the Civil war.
Food Supply of Partisan Formations of Belarus During the Nazi Occupation (Based on the Materials of the Vitebsk Region)
Authors:   Peter the Great St. Petersburg Polytechnic University, Krasnozhenova E. E. , Kulinok S. V. ,   National Archives of the Republic of Belarus
Published: November 2021

During the Great Patriotic War, a massive and well-organized partisan movement developed on the territory of the BSSR. In the conditions of struggle behind enemy lines, the material and technical (including food) support for “forest soldiers” was of crucial importance for its quantitative and qualitative growth. The initial policy of the Soviet government to maximize the self-sufficiency of partisan detachments at the expense of trophies and food captured from the enemy was ineffective. With the creation of the Belarusian headquarters of the partisan movement, as well as with the organization of partisan airfields and sites, the supply of food (primarily salt and tobacco) became regular. The main source of food for the “forest soldiers” were products obtained during procurement and economic operations from the civilian population. Because of the “food issue.” the attitude of the local population to the partisans was not always positive. There were cases of abuses by the partisan leadership during procurement operations, as well as cases of looting. The leading partisan and party bodies actively fought against offenses among the partisans, but it was not possible to completely eradicate this phenomenon. At the same time, in some cases partisans themselves distributed food and livestock to the civilian population. In some detachments and brigades, small enterprises were organized that produced food products (creameries, small slaughterhouses, bakeries, etc.). In general, during the occupation, the partisans managed to solve the issue of food supply to one degree or another, which had a positive impact on the dynamics of growth in the number of “forest soldiers” and on the combat and moral qualities of the personnel.