bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH SALESMANSHIP TERHADAP MINAT BELI MOBIL TOYOTA AVANZA PADA PT. AGUNG TOYOTA PAL 10 KOTA JAMBI
Authors: Marsyaf Agesha , Zebua Ade Jermawinsyah
Published: September 2022

Sebagai pelaku bisnis perusahaan harus memiliki pengetahuan tentang lingkungan, pesaing, perilaku konsumen, serta kekuatan dan kelemahan diri sendiri yang dimiliki perusahaan. Adanya penguasaan teknik dan strategi dalam melakukan pendekatan pasar dalam mengelola hal-hal tersebut, perusahaan dapat “menjual” produk dan jasanya masing- masing, serta melakukan perubahan dan pengembangan sikap, dan didapatkan hasil yang optimal sesuai dengan apa yang telah direncanakan.peranan yang penting dalam membantu perusahaan menerapkan strategi pemasaran yang berorientasi pembeli sebagai sasarannya yaitu Salesmanshipseorang Salesman harus memahami, menguasai, dan melaksanakan kegiatan penjualan dan pemasaran dalam mencapai target penjualan perusahaan. Target penjualan disini dapat berupa barang ataupun jasa, sebagai produk dari masing-masing perusahaan.Perusahaan yang melakukan pemasaran produknya dengan menggunakan tenaga penjual (salesmanship). Persepsi hasil dari para responden yang diperoleh melalui hasil kuesioner 65 responden, bahwa dari hasil uji hipotesis dengan menggunakan uji hipotesis t ditemukan bahwa terdapat pengaruh yang positif dan signifikan antara variabel salesmanship dan minat beli mobil toyota avanza
The Value of Sustainable Tourism Destinations in the Eyes of Visitors
Authors:   Department of Economics, University of Bologna, 40126 Bologna, Italy, Stacchini Annalisa , Guizzardi Andrea ,   Department of Statistical Sciences “Paolo Fortunati” and Center for Advanced Studies on Tourism, University of Bologna, 40126 Bologna, Italy, Costa Michele ,   Department of Economics and Center for Advanced Studies on Tourism, University of Bologna, 40126 Bologna, Italy
Published: September 2022

The first objective of this study is to analyze visitors’ perceived value of four Italian small areas, that have been granted the European Regional Development Fund’s financing for developing sustainable tourism. The second objective of this work is to investigate the influences of socio-demographic and trip-related characteristics on the tourists’ assessments of the main aspects of such destinations, for detecting variables useful for market segmentation and for designing better-targeted marketing actions. These areas host protected natural reserves, historical heritage, rural or mountain traditions, and ways of life, the conservation of which is combined with local economic growth through the development of green, cultural, and slow tourism. Thus, insights on how visitors’ perceived value is configured there might provide hints useful for upgrading the local tourism supply consistently with the United Nations’ Agenda 2030 for sustainable development and the European Green Deal Strategy. Results confirm that the perceived value is a fundamental construct, as it strongly and positively influences satisfaction, intention to recommend, and destination image. The value of sustainable destinations, as perceived by visitors, is mainly based on the affective benefits that sustainable experiences provide, starting from positive social interactions making tourists feel welcomed. The tourist segment valorizing sustainable destinations is mostly composed of old people and low-income travelers, who seek basic services and facilities, as their satisfaction depends mainly on relaxing immersed in pristine nature.
Preface: 2022 International Conference on Governance of Accounting and Global Business Management (GAGBM 2022)
Authors: Craigie Gordon , Chi Hongbin
Published: September 2022

The 2022 International Conference on Governance of Accounting and Global Business Management (GAGBM 2022) was successfully held in Yantai, China from July 16-17, 2022 by the Shanghai Maritime University, University of Leicester and University of South Australia. The conference offered extraordinary opportunities for educators, teachers, researchers, administrators and decision-makers to exchange and gain new insights on the ongoing research works and an opportunity to collaborate with like-minded researchers from across the world. This conference covered a variety of sessions, including the works on 1) governance of accounting; 2) economic development; 3) finance & investment; 4) marketing research and strategy; and 5) global business management.

GAGBM 2022 is a platform for researchers, engineers, academics and industry professionals from around the world to showcase their sustainability and research results and development activities in marketing research and global business management. We sincerely invite all researchers, scholars, engineers, students and people to be interested in these areas and participate in our conference.

On behalf of the committee, we would like to thank the authors, reviewers, advisory board, committee members, presenters, and participants. Recognition should go to the GAGBM 2022 team members who have all worked extremely hard for the details of important aspects of the conference programs and social activities. Special thanks are also given to the conference proceedings publisher. We would like to thank all parties for their participation in supporting this publication. We hope to see you all at the next conference.

Kind regards,

GAGBM Organizing Committees

Yantai, China
The Application of the Fama-French Five Factors Model on the U.S Meals Industry During COVID-19
Authors: Du Xinhe , Zhao Yuhan
Published: September 2022

The COVID-19 pandemic has posed unexpected threats to the world, and the healthcare system was overwhelmed and imposing enormous problems for the governments. People’s living environment, consuming behaviors, and investment decisions are primarily affected and changed under the new environment. The dramatic fluctuations in the stock markets reflect the investors’ pessimistic sentiment towards the future. This paper presents an approach to give an overview of the changes in the Meals Industry by using the Fama-French Five Factors Model. The results obtained from the research reveal three significant changes in the determinants of investment decisions for the meals-related industry, which are HML, RMW, and CMA. The preliminary results will help investors identify the change in market preferences and help the firms to recognize the proper adjustment during the epidemic period.
Economic Policy Uncertainty and Corporate Inefficient Investment: A Research Based on Fixed Effects Model with Evidence from China
Authors: Li Jianan , Liao Shiyue , Liu Jingtong , Lyu Yue
Published: September 2022

Investment decision-making is the core of corporate financial decision-making, which has a vital influence on investment income and shareholder wealth. This paper will use the fixed effects model to study the relationship between policy certainty and inefficient investment of enterprises, and the data of Chinese companies used are from the CSMAR database. This article first studies the correlation between inefficient investment and policy uncertainty. Based on the research on the relationship between economic policy uncertainty and corporate inefficient investment, this paper finds that economic policy uncertainty has a negative impact on the investment efficiency of enterprises. This conclusion is still valid after a series of robustness tests, including adding some omitted variables and fixed effects of the research year and industry. And through heterogeneous analysis, this paper finds that the investment efficiency of small-scale and low-quality auditing companies is more affected by economic policy uncertainty.
Economic policy uncertainty and corporate investment efficiency: Evidence from China - Based on panel data
Authors: Du Jianhao , Lu Yuqing , Ma Zhaorong , Xing Shujie
Published: September 2022

This paper studies the impact of economic policy uncertainty on corporate investment efficiency. The study finds that economic policy uncertainty has a significantly positive impact on corporate investment efficiency. In addition, the positive relationship is still robust after conducting a series of robustness checks. Further analyses show that the impact of economic policy uncertainty on corporate investment efficiency is more pronounced in firms that do not employ Big 4 auditors, are non-state-owned, and have fewer analysts. By exploring the economic channel, this study shows that economic policy uncertainty is related to higher information disclosure quality. Firms with higher information disclosure quality tend to improve their corporate investment efficiency when economic policy uncertainty increases. Findings show that the increase in economic policy uncertainty in China's capital market can improve corporate information disclosure quality and further improve corporate investment efficiency.
Internal control issues in Shanghai Jahwa under the normalization of novel coronavirus prevention and control Research
Authors: Ma Jiayi
Published: September 2022

With the normalization of the novel coronavirus, the internal control system of the company will also produce some changes to adapt to the changes of the external environment. In this paper, Shanghai Jahwa United Co., Ltd. will be selected as the subject of study to discuss three aspects of internal environment, business activities, and risk assessment to point out its strengths and weaknesses and identify its changes. This paper compares Shanghai Jahwa with the industry average thus making a comparative judgment, on the premise of concluding that Shanghai Jahwa's novel coronavirus is normalized and the industry average can also be judged.
Research on China's Green Finance Credit Risk Measurement Based on Improved KMV Model — Credit risk assessment of new energy automobile industry
Authors: Nie Yajun
Published: September 2022

This paper focuses on the issue of green finance credit risk measurement, taking China's new energy vehicle listed companies as a sample, taking into account the actual situation of China's financial market, using a modified KMV model to estimate the default distance of selected companies, and comparing with the traditional industries in these three years. The results show that the average default distance of 30 new energy automobile companies is larger than that of 30 traditional automobile manufacturing companies, and the default probability is smaller. As the credit loan risk for the new-energy automobile industry is lower, commercial banks are encouraged to carry out green credit business, and policy and subsidy support related to the new-energy industry shall be given at the same time.
Research Progress on Agricultural Land Stock Cooperative
Authors: Zhu Jinghuan , Wang Shilong
Published: September 2022

As a special form of land circulation, land joint-stock cooperatives have become a trend of land development in the future, and have attracted widespread attention in the academic community. Many scholars have conducted in-depth research on the research of the land share cooperation system, the reasons for its emergence, its role and the influencing factors of participation willingness. On this basis, this paper combs the land share cooperatives in order to provide some reference value for the comprehensive research and future development direction of land share cooperatives.
Study of the Cross-Section for the 122Te(γ, n)121Te Reaction by the Activation Method
Authors: POP OKSANA , MAZUR VOLODYMYR , DERECHKEI PETRO , Bigan ZOYA
Published: September 2022

Relevance. The study of photonuclear reactions plays a defining role in the formation of modern ideas about highlocalized collective excitations in nuclei of the giant resonance type. The giant dipole E1-resonance (GR) is the main feature in γ-quantum absorption cross-sections of nuclei. The presence of isotopes with multiple isotopes makes it possible to trace the evolution of GR characteristics from changes in the number of neutrons in the nuclei. One such element is tellurium.

Purpose. The purpose of this research is an experimental and theoretical study of the cross-section of 122Te(γ, n)121Te reaction in the region of giant E1-resonance energies.

Methods. The study of the cross-section of (γ, n) reaction on 122Te isotope was performed on the bremsstrahlung γ-beam of the M-30 microtron of the Institute of Electronic Physics of the National Academy of Sciences of Ukraine. The yield curves were measured in the range of maximum gamma-quantum energies Eγmax=10-18 MeV. The reaction cross-section was calculated by the inverse matrix method. When registering the reaction products, an activation technique was used, while the gamma activity of the products was recorded by the spectrometric method. The theoretical calculations of the cross-section for the 122Te(γ, n)121Te reaction were performed using the TALYS-1.9 software package.

Results. The measured experimental yield ratios of the 122Te(γ, n)121Te і 130Te(γ, n)129Te d= Yn121 /Yn129 = f (E max) reactions allowed the experimental cross-section for the 122Te(γ, n)121Te reaction to be calculated. The cross-section has a single hump shape with a maximum at an energy of ~ 15.3 MeV. It was approximated by the Lorentz curve with the parameters δ0 =(274.1±2.1) MB, Е0 (15.27±0.10) MeV, Г0 =(4.76±0.08) MeV. The cross-section obtained was compared with similar cross-sections for 126Te and 130Te isotopes, as well as with theoretical calculations according to the TALYS-1.9 program.

Conclusions. The obtained cross-section for the 122Te(γ, n)121Te reaction is consistent with the evolution of the parameters of (γ, n) reaction cross-section on tellurium isotopes 130Te(γ, n)129Te with a change in the number of neutrons. The theoretical approaches used are satisfactorily consistent with the experimental data. This agreement indicates the main contribution of the statistical mechanism to the cross-section of the considered (γ, n) reaction and a relatively small contribution of semi-direct processes
Effects of Repulsion and Attraction between Rotating Cylinders in Fluids
Authors: OSTANIN VADYM
Published: September 2022

Relevance. From the theory of hydrodynamics, it is known about the interaction of a pair of vortices in inviscid fluids. The relevance of the study is conditioned upon the presence of many studies of numerical simulations of the interactions of two vortices or two cylinders, but the lack of research of practical installations for observing the effects of attraction and repulsion in fluid media may slow down research in this area for practical application.

Purpose. The purpose of this study is a practical demonstration of the possibility of the effect of double interaction in the air, with the calculation of the approximate magnitude of the force tending to attract or repel each of the cylinders.

Methods. In a practical experiment, a pair of plastic cylinders are used, which are driven by engines and rotate next to each other in the air at atmospheric pressure. Numerical simulation of the effect shows the nature of the effect and allows predicting the magnitude of the force generated by rotating cylinders on each other. The relationship between the directions of rotation of the cylinders and the observed effects was verified by numerical simulation using numerical simulation of finite volumes of OpenFOAM version 9.

Results. In a practical experiment, a pair of rotating cylinders started interacting at 5-7 cm in the experiment, which at a smaller distance of 2-3 cm created sufficient force to stabilise the vibrations of one of the cylinders around the thread for which it is suspended. Numerical simulation shows that a zone of high or low pressure is formed in the space between the cylinders, depending on the direction of rotation. The rotation of adjacent disks with opposite directions of rotation helps the circulation of the other cylinder to maintain the flow velocity in the gap, which reduces the fluid pressure between the rotating disks and attracts them. Conversely, rotating disks with the same direction extinguish and compress fluid flows in the gap, which increases the air pressure between rotating objects above the stationary pressure and repels them.

Conclusions. The results of the study provide a better understanding of the processes of fluid interaction, link the dependence of the interaction force on the parameters of the medium and cylinders, and demonstrate the practical possibility of applying the effects of interaction in fluid media
Analisa Laporan Keuangan Dan Benchmark Perpajakan (Studi Kasus PT Kimia Farma Tbk Tahun 2019-2021)
Authors: Manurung Gidion Samuel , Rahman Hafidz Taqullah , Lestari Lisa Fitri , Fajri Luqman , Candra Malo Muhamad Wildan , Putra Naufal Rafif Kusuma , Laksonoputra Nigella Sativa , Prebawa Putu Arya Wahyu , Ulhaq Raihan Dhiya , Khosafiah Ristanti Khusnul , Jusikusuma Teta Dirgantara , Aji Wahyu Kartika , Pamungkas Wahyu , Yuditama Yudit , Wijaya Suparna
Published: September 2022

This article aims to determine the financial performance of PT Kimia Farma based on financial statement analysis and DGT benchmark analysis according to SE-96/PJ/2009 regarding the Total Benchmarking Ratio and its Utilization. Financial statement analysis is the process of analyzing financial statements used by users of financial statements for decision making. Benchmarking is the process of comparing the financial performance of similar companies with certain ratios to determine whether the company is fair or not. The method used in this study is a qualitative method with secondary data in the form of financial statement data sourced from the Indonesia Stock Exchange (IDX). The financial statements used are the 2019-2021 financial statements before, during, and after the Covid-19 pandemic took place. What is meant by post-pandemic is when the Covid-19 rate begins to decline from its peak in 2021. The results show that there is a significant increase, but it is far from efficient. Under these circumstances, PT Kimia Farma's financial performance should be better because it is engaged in the pharmaceutical industry. So that there is a need for continuous evaluation regarding why the company cannot show satisfactory financial performance.

Artikel ini bertujuan untuk mengetahui kinerja keuangan PT Kimia Farma berdasarkan analisa laporan keuangan dan analisa benchmark DJP menurut SE-96/PJ/2009 tentang Rasio Total Benchmarking dan Petunjuk Pemanfaatannya. Analisa laporan keuangan adalah proses analisis terhadap laporan keuangan yang digunakan oleh para pengguna laporan keuangan untuk pengambilan keputusan. Benchmarking adalah proses pembandingan kinerja keuangan terhadap perusahaan sejenis dengan rasio-rasio tertentu untuk menentukan apakah perusahaan tersebut wajar atau tidak wajar. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan data sekunder berupa data laporan keuangan yang bersumber dari bursa efek Indonesia (BEI). Laporan keuangan yang digunakan adalah laporan keuangan tahun 2019-2021 pada saat sebelum, saat, dan sesudah pandemi Covid-19 berlangsung. Yang dimaksud sesudah pandemi, yaitu saat tingkat Covid-19 mulai menurun dari puncaknya pada tahun 2021. Hasilnya menunjukkan bahwa terdapat peningkatan yang signifikan, tetapi jauh dari kata efisien. Dalam keadaan tersebut seharusnya kinerja keuangan PT Kimia Farma dapat lebih baik karena bergerak di bidang industri farmasi. Sehingga perlu adanya evaluasi yang berlanjut terkait mengapa perusahaan tersebut tidak dapat menunjukkan kinerja keuangan yang memuaskan.
La franquicia: de la inversión al emprendimiento
Authors: Gómez Miranda Oscar Mauricio
Published: September 2022

La franquicia es un modelo de negocio que no se ha investigado lo suficiente en Colombia, aun cuando tiene un gran potencial de crecimiento. Por esta razón, la franquicia pareciera un modelo organizacional y de relación contractual estático, sin embargo, es un sistema de negocio que ha presentado cambios en la forma como se proyecta y se entiende. Así, la franquicia se percibe como un sistema dinámico y en constante evolución, cuyo objetivo es identificar el cambio de enfoque de la franquicia como un modelo de inversión a un sistema de emprendimiento. Los resultados más importantes indican que la motivación del individuo, el tiempo dedicado a la gestión de la franquicia, los recursos económicos disponibles y la gestión que realizara sobre la empresa, son los aspectos más valorados por el franquiciador para elegir el franquiciado. En consonancia, los franquiciadores buscan personas con enfoque emprendedor, interesadas en invertir y en operar la empresa.
نسخ قرآن کی مختلف تعبیرات: معاصر تفسیری رجحانات کا مطالعہ
Different Interpretations of the Qur'an: A Study of Contemporary Commentary Trends
Authors: Ali Muhammad Rifaqat
Published: September 2022

From the very beginning, abrogation has been given special importance by Muslim scholars. There is a consensus among the Muslim Ummah on the fact of abrogation. Only a few people denied this fact. Everyone has agreed on the occurrence of abrogation in the Holy Qur’an; however, scholars and researchers have been differing in its nature. Qur'anic exegetical literature has great importance among Islamic scholars. While interpreting the Holy Qur'an, various commentators have discussed the abrogation in detail. The commentators of Urdu Qur'anic exegetical literature also seem to be in favour of abrogation in the Holy Qur'an. In these commentaries, not only the verses related to abrogation have been described, but in some commentaries, the causes and circumstances of revelation have been described in such detail that after reading these commentaries, there remains no need to search for related books.
Sir Syed Ahmad Khan and Ghulam Ahmad Pervez are among the commentators who have worked hard to harmonize the commentary with Western thought. As a result of this struggle, they denied the abrogation in the holy Quran.
Most of the commentators of the subcontinent agree that the Qur'anic Verses may have been abrogated. However, they split into two groups. Some have expanded the concept of abrogation, while others have accepted the abrogation of only a few verses of the Holy Qur'an. There was a need to highlight and compare the views of both classes. The article under review is an attempt to fill this gap.
The application of Robotic Process Automation in the financial accounting in entities that operate in Poland
Authors: Remlein Marzena , Bejger Piotr , Olejnik Iwona , Jastrzębowski Artur , Obrzeżgiewicz Dawid
Published: September 2022

Purpose: The article discusses the concept of Robotic Process Automation (RPA) and examines the level of its application in the area of financial accounting in Polish compa-nies.
Methodology/approach: The article uses quantitative research in the form of a ques-tionnaire, which was conducted based on a purposeful sampling of respondents. Taking into account the nature of the questions and scales included in the research tool, de-scriptive statistics measures were used in the data analysis in the study.
Findings: The research showed that among entities that use RPA in Poland, robotiza-tion is mainly used in the area of financial accounting. Further analysis indicated that robots are implemented mainly either in processes with a high volume of transactions (like sales or purchases) or in processes determined by internally generated data (month-end closing, financial reporting). It also shows that entities that implemented RPA mainly have a long history of operation and are large corporations employing over 1,000 employees.
Research limitations/implications: The article is a contribution to research on the use of RPA in accounting and it identifies the benefits and threats that result from us-ing RPA.
Practical implications: This article indicates that financial accounting is the area that is most often the subject of robotization among entities that apply RPA in Poland. Addi-tionally, it presents the specific processes within financial accounting in which the ap-plication of robotization is most popular. The results of the research give a clear direc-tion both for the companies that are at the initial stage of implementing RPA and those that are considering expanding its application.
Originality/value: The article covers the current and relatively little-known area of contemporary financial accounting. The literature review, especially the Polish litera-ture, indicates that the area of applying RPA in accounting is a new topic. This study is one of the first to present the results of research conducted among entities operating in Poland.
COVID-19 Pandemisinde Semptomlar ve Vaka Profilinin Veri Madenciliği Yaklaşımıyla İncelenmesi
Authors: KARAHAN ADALI Gökçe
Published: September 2022

Tüm dünyaya hızla yayılan Corona virüsü 2019 (COVID-19), SARS ve MERS salgınları sonrası görülen üçüncü koronavirüs salgını olarak tüm dünyayı etkisi altına almıştır. Virüs dünya çapında halk sağlığı için büyük bir tehdit olmaya devam etmektedir. Dünya sağlık örgütü tarafından pandemi ilan edilen bu salgın, insanların sağlığına, eğitimine, sosyalleşmelerine ve küresel ekonomiye çok büyük etkiler bırakan önemli bir halk sağlığı krizidir. COVID-19’a daha hızlı yanıt verebilmek için her yönüyle çalışmalar devam etmektedir. Bu kapsamda hastalığın seyrinde, hastaların benzer özellikleri taşıdıkları semptomlar ve iyileşme sürecine etkileri önem arz etmektedir.

Bu çalışma, COVID-19 hastaları arasında yaş, cinsiyet, hastalığın seyrinde görülen semptomlar, iyileşme ve ölüm durumunda etkili birliktelikleri ortaya çıkarmayı amaçlamaktadır. Çalışmada, sık görülen semptomları belirlemek ve demografik verilerin iyileşme sürecine etkilerini çıkarmak için birliktelik kuralı adı verilen ve yaygın olarak kullanılan makine öğrenimi tekniği R programlama dili kullanılarak uygulanmıştır.

Elde edilen kurallarda, salgına yakalanmada yaş faktörünün büyük ölçüde etken olduğu tespit edilmiştir. En belirgin semptom olarak ateş ortaya konmuştur. Ateş semptomunu takiben öksürük semptomunun hastalar arasında sıklıkla rastlandığı görülmektedir. Analizler sonucunda, ölüm oranlarında yaşlı bireylerin ve erkeklerin kadınlara göre daha çok kayıp verdiği tespit edilmiştir.
Herramientas digitales para la educación médica en el contexto del COVID-19
Authors: Alvarado-Rodríguez Yazlin , Galán-Rodas Edén
Published: September 2022

Desde la declaratoria de pandemia por la Organización Mundial de la Salud, el 11 de marzo del 2020(1), en el mundo entero se decretaron estados de emergencia por las graves circunstancias que afectaban la vida de las personas a consecuencia de la enfermedad producida por el virus SARS-CoV-2 (COVID-19), siendo el aislamiento social obligatorio, la principal medida con la que se pretendió mantener en confinamiento a las personas junto a otras medidas sanitarias, sociales y económicas.

A la fecha (mayo 2022), en el mundo existen más de 531 millones de personas infectadas y más de 6 millones de fallecidos a causa de esta enfermedad(2), lo que ha significado un reto para la economía y los sistemas de salud de los países más afectados a nivel global. En ese contexto, otro escenario bastante afectado por la pandemia lo representa la educación, con el cierre de aulas en todos sus niveles, pero particularmente por la alta demanda y afectación de los sistemas de salud, la educación universitaria en carreras de ciencias de la salud y especialmente la educación médica.
Úlceras genitales crónicas por virus del herpes simple en paciente inmunocomprometido: reporte de caso
Authors: Baquedano-Ordoñez Abner , Martel-Ramos Benilda
Published: September 2022

El herpes genital es una infección de transmisión sexual vírica que representa la causa más frecuente de úlcera genital. Clínicamente, cursa con episodios recurrentes, asintomáticos, o con lesiones características como vesículas-úlceras. En nuestro medio, el diagnóstico es eminentemente clínico, aunque existen pruebas laboratoriales para su confirmación, el tratamiento de elección consiste en fármacos antivirales sistémicos, que acortan el tiempo de eliminación del virus, aunque no evitan la recidiva. Además, es importante recordar su frecuente predisposición con otras ITS, en especial, el VIH/SIDA como en este caso.
Đánh giá tình trạng bệnh lý tai mũi họng sau nhiễm COVID-19 của học viên, sinh viên tại Học viện Quân y
Authors: Đỗ Lan Hương Đỗ Lan Hương , Nguyễn Thúy Nhường Nguyễn Thúy Nhường , Trần Quang Mạnh Trần Quang Mạnh , Nguyễn Vân Anh Nguyễn Vân Anh , Vũ Tùng Lâm Vũ Tùng Lâm , Nguyễn Phi Long Nguyễn Phi Long
Published: September 2022

Mục tiêu: Mô tả một số đặc điểm bệnh lý tai mũi họng (TMH) sau nhiễm COVID-19 mức độ trung bình và nhẹ ở các học viên, sinh viên tại Học viện Quân y. Đối tượng và phương pháp: Nghiên cứu mô tả, cắt ngang có theo dõi trên 793 học viên, sinh viên bị nhiễm COVID-19 mức độ trung bình và nhẹ tại Học viện Quân y từ tháng 4/2021 - 6/2022. Kết quả: Triệu chứng khi nhiễm COVID-19: Ho 75,16%, ngạt mũi 74,53%, đau họng 73,01%, chảy dịch mũi 65,32%, ù tai 11,35%. Triệu chứng kéo dài sau nhiễm COVID-19 ho 34,55%, ngạt mũi 6,05%, mệt mỏi 6,94%, đau họng 7,57%, đau đầu 5,55%, sốt 0,38%. Thời gian trở lại sinh hoạt, học tập bình thường sau nhiễm COVID-19 từ 8 - 14 ngày 52,59%, trong vòng 7 ngày 40,82%. 66,0% học viên có nhu cầu đi khám và điều trị bệnh lý TMH sau nhiễm COVID-19. Một số triệu chứng ảnh hưởng nhiều và nghiêm trọng đến học tập sinh hoạt của học viên: Ho (9,08% và 2,02%), ngạt mũi (7,69% và 0,26%), chảy dịch mũi (7,94% và 0,38%), khàn tiếng (1,01% và 1,89%). Kết luận: Triệu chứng TMH được ghi nhận chủ yếu trong khoảng 7 ngày khi nhiễm COVID-19. Các triệu chứng này phần lớn kéo dài sau nhiễm COVID-19 và trong 1 tháng, không ảnh hưởng hoặc ảnh hưởng ít đến sinh hoạt và học tập của các học viên. Tuy nhiên, các triệu chứng có thể gây ảnh hưởng nhiều hoặc nghiêm trọng đến học tập và sinh hoạt của học viên và phần lớn học viên đều có nhu cầu được thăm khám và điều trị các bệnh lý TMH sau  nhiễm COVID-19.

* Từ khóa: COVID-19; Hậu COVID-19; Triệu chứng tai mũi họng.
Assessment of clinical, paraclinical characteristics of patients receiving concomitant mitral and aortic valve replacement with On-X mechanical prosthesis at Bach Mai Hospital
Authors: Ngo Phi Long  , Duong Duc Hung  , Nguyen Truong Giang
Published: September 2022

Objectives: To investigate clinical and paraclinical characteristics of patients undergoing concomitant mitral and aortic valve replacement with On-X mechanical valve at Bach Mai Hospital. Subjects and methods: This was a non-controlled, prospective, descriptive study on 100 patients with severe aortic and mitral diseases undergoing concomitant aortic and mitral valve replacement with On-X valve. Clinical and paraclinical parameters were selected based on Vietnam National Heart Association and ACC/AHA guidelines. Results: Clinical manifestations included history of rheumatic heart disease (70.0%), NYHA          class II (36.0%), NYHA class III (64.0%), atrial fibrillation (67.0%). Echocardiography showed dilated left ventricle (LVEDd 55.2 ± 8.9 mm, LVEDs 37.3 ± 8.1 mm), preserved left ventricular ejection fraction (63.9 ± 9.5%), moderately pulmonary arterial hypertension (47.2 ± 13.8 mmHg), and dilated left atrium (53.8 ± 10.5 mm). Conclusion: Most patients undergoing concomitant On-X aortic and mitral prosthetic valve replacement presented with moderate and severe heart failure, dilated left ventricle and left atrium, and increased pulmonary arterial pressure.

* Keywords: Mitral and aortic valve replacement; On-X valve.
Evaluation of acid-thermal pretreatments and enzymatic saccharification to obtain fermentable sugars from the juice and bagasse of Agave salmiana leaves
Authors: Martínez-Hernández Sergio , Hernández-Mendoza Alonso Guadalupe , Ruiz-Leza Héctor Arturo , Ortiz-Ceballos Angel Isauro , Castro-Luna Alejandro Antonio , Láinez-González Magdiel
Published: September 2022

This study presents the results of acid-thermal pretreatments and enzymatic saccharification for the production of fermentable sugars from the juice and bagasse of Agave salmiana leaves. In the acid-thermal pretreatment, H2SO4 was used while in the enzymatic saccharification the commercial enzyme Cellic Ctec2 (Novozyme) was used. In the results it was found that the best conditions of the acid thermal pretreatment (H2SO4 % (v/v) at 100 ° C for 30 min) for the juice generated a concentration of 43.65 ± 1.36 g/L of reducing sugars. In bagasse, the best conditions (H2SO4 % (p/v) at 120 ° C for 60 min) produced a concentration of 37.35 ± 1.65 g/L of reducing sugars in the hydrolysates. In the enzymatic saccharification at 15 FPU/g substrate and solids load of 10 % (p/v), a concentration of 87.37 ± 1.27 g/L of reducing sugars was obtained after 72 h. The results obtained demonstrate the potential of the integral use of bagasse and juices from the leaves of Agave salmiana as raw material to produce fermentable sugars.
(in)visibilidade da interculturalidade em um Curso de Licenciatura em Música
Authors: Araujo Eli de Matos , De Almeida Jéssica
Published: September 2022

Este artigo tem o objetivo de apresentar resultados parciais de uma pesquisa de mestrado que analisou como discentes de um Curso de Licenciatura em Música do Norte do Brasil desenvolvem, em suas práticas acadêmico-docentes, uma perspectiva de educação musical intercultural. Para tanto, toma-se como pressupostos as considerações de Walsh (2012) e Queiroz (2004) sobre a interculturalidade, embebidas de princípios decoloniais, e a necessidade de se repensar a formação acadêmico-docente em uma concepção de educação musical abrangente, que atenda demandas da sociedade contemporânea e que faça ouvir, também, conhecimentos musicais não hegemônicos. Para isso, a referida pesquisa foi desenvolvida através de uma abordagem qualitativa de fundamento fenomenológico a partir de pesquisa documental e da realização de entrevistas com três acadêmicos, orientando-se pela análise de conteúdo (BARDIN, 2011). Neste recorte, enfoca-se os resultados parciais da pesquisa documental esperando contribuir com a formação docente para o ensino de música embasada na perspectiva intercultural.
Empresas y emprendimientos turísticos de la Región Este de Uruguay: una aproximación a su estado de situación en el contexto del COVID-19
Authors: Zorzi Mariciana , Bula Kristina , Bianchi Facundo , Campodónico Gabriela , Angelo Gabriela
Published: September 2022

Este artículo presenta los resultados de una investigación desarrollada desde junio de 2020, mediante la aplicación de  una encuesta a empresas y emprendimientos turísticos de la Región Este de Uruguay; con el objetivo de aproximarse a la situación de los mismos en el contexto de la emergencia sanitaria ocasionada por el COVID-19. Entre los resultados obtenidos se destaca que: la mayoría de las empresas consultadas cesaron sus actividades, dadas las dinámicas propias del territorio y/o por la emergencia sanitaria; gran parte de las empresas no accedieron a las medidas oficiales de contención y reactivación del sector y la mayoría de las empresas entiende que el turismo interno posibilitará su sostén a futuro.
A realidade do outro em realidade virtual: experiências imersivas e multissensoriais para comunicar a empatia
Authors: Couto Tiago , Zilles Borba Eduardo
Published: September 2022

O artigo discute as potencialidades de uso da Realidade Virtual (RV) para a promoção do comportamento empático no usuário. Parte-se do entendimento de que a exploração imersiva e multissensorial de contextos digitais que simulam situações de adversidades e/ou preconceitos estimulam o sujeito a perceber-se no lugar do outro. A metodologia inicia-se com uma revisão bibliográfica para, em seguida, avançar com a exploração de duas peças em RV que exercitam a empatia. Os resultados sintetizam sugestões para se estudar ou desenvolver ações de empatia através da RV.
Taking a Spatial Turn in Mathematics Teacher Education
Authors: Weiland Travis , Poling Lisa L.
Published: September 2022

The spaces we inhabit and the physical communities in which we learn all affect how we come to experience the world, construct what mathematics is to us, and develop how we teach mathematics. In this theory-to-practice article, we discuss why explicitly considering spatial ways of knowing is important in mathematics teacher education. We begin by providing theoretical arguments for the importance of considering space in mathematics education. We then present a rationale for why considering space is so important in mathematics teacher education, specifically discussing links to the practice of teaching mathematics. Examples of how to consider tasks related to spatial justice are provided to help reimagine what an mathematics teacher education task can look like.
Response to Selpercatinib in a Patient With Recurrent Glioblastoma and RET Amplification
Authors: Czech Cameron , Chen Ashley , Morgan Katherine P. , Zamora Carlos , El-Refai Sherif , Poynter Norleena , Khagi Simon
Published: September 2022

Glioblastoma (GBM) is a malignant central nervous system neoplasm that remains largely incurable. Limited treatment options currently exist after disease progression on standard-of-care first-line therapy. However, repurposing the use of approved therapies in patients with potentially targetable genomic alterations continues to be an emerging area of interest. This report presents the first description of a patient with isocitrate dehydrogenase wild-type GBM with an underlying RET amplification who demonstrated a near-complete response while receiving therapy with the RET inhibitor selpercatinib. The case highlights the excellent blood-brain barrier penetration of selpercatinib, as well as its potential role in the management of RET-amplified GBM. Larger biomarker-enriched studies are needed to confirm the results of this case report. Given the rare incidence of RET alterations in GBM, findings from this report can help guide and support optimal treatment strategies for patients with RET-altered GBM.
A New Approach in Brand Measurement Models and Its Implementation in The Health Sector: Statistical Measurements and Evaluations
Authors: DÜZCÜ Tuba , ZÜLFİKAR Haluk
Published: September 2022

Günümüzde tüm işletmelerde olduğu gibi sağlık sektöründe de marka imajı ve marka algısına çok fazla önem verilmektedirler. Pazarlama bakımından marka imajı önemli bir etkiye sahipken marka algısı genel kavramla müşterilerin satın alma
davranışını tetikleyen önemli bir işleve sahiptir. Bu çalışmanın amacı, sağlık sektöründe marka imajı ve algısı ölçeğinin güvenirlilik analizlerini gerçekleştirmek ve literatüre yeni bir ölçek kazandırmaktır. Bu amaçla, çalışmaya
dahil edilen sağlık grubu ve ilaç şirketi için 18-64 yaş aralığındaki toplamda 221 hasta ve 18 fikir liderine yüz yüze anket uygulanarak araştırma verisi toplanmıştır. Çalışmada toplanan veriler SPSS Windows 20.00 ve AMOS 22.0
programı kullanılarak analiz edilmiş, elde edilen veriler istatistiksel analizlere tabi tutularak sırasıyla, demografik yüzdesel dağılım, doğrulayıcı faktör analizi, açımlayıcı faktör analizleri elde edilmiştir. Ayrıca, istatistiksel
veri analizi ile Cronbach Alpha değeri, ayrışma geçerliliği açıklanan varyans değerlerine bakılmıştır. Elde edilen bulgulara göre ölçeğin marka şahsiyeti ile marka gücü ana boyutları altında toplamda altı adet alt boyutta ölçek
ifadelerinin toplandığı sonucuna ulaşılmıştır. Bu çalışma ile sağlık sektöründe marka imajı, marka algısı konularında bilimsel araştırma yapmak isteyen araştırmacılara istatistiksel veriler sunulmuştur.
Investigation of Self-Confidence Emotional States of University Students receiving sports education
Authors: DOĞAN Erol
Published: September 2022

Bu çalışmada spor eğitimi alan üniversite öğrencilerde özgüven duygu durumlarının araştırılması amaçlanmıştır. Toplam 315 öğrencinin doldurmuş olduğu özgüven ölçeği değerlendirilmiştir. İstatistiksel işlemlerde bağımsız t- testi, tek
yönlü varyans analizi (ANOVA) ve LSD testleri kullanılmıştır. Cinsiyete göre iç özgüven ve dış özgüven alt boyutu ve toplam özgüven puanları arasında anlamlı bir farklılık bulunmamıştır (p>0,05). Yaş seviyesine göre iç özgüven,
dış özgüven ve toplam özgüvende anlamlı bir farklılık tespit edilmemiştir (p>0,05). Öğrencilerin okuduğu bölüme göre iç özgüven ve dış özgüven alt boyutunda ve özgüvende anlamlı farklılık bulunmamıştır (p>0,05). Öğrencilerin
kaldığı yere göre dış özgüven alt boyutunda ve özgüvende anlamlı farklılık vardır (p<0,05). Evde kalan öğrencilerin yurtta kalan öğrencilere göre dış özgüvenleri ve özgüvenleri daha iyidir. Sonuç: Spor Fakültesi öğrencilerinin
cinsiyet, yaş kategorisi, sınıf ve bölüm değişkenine göre özgüvenlerinin benzer olduğu tespit edilmiştir. Öğrencilerin özgüven duyguları yüksek kabul edilebilir. Bu nedenle öğrencilerin kendini sevme, kendini tanıma, kendini iyi
ifade edebilme, kendini ortaya koyma ve duygularını kontrol etme, kendine açık hedefler koyma, pozitif düşünme, duygularını kontrol edebilme ve iletişim becerileri iyi olarak kabul edilebilir. Bunun yanında evde kalan öğrencilerin
yurtlarda kalan öğrencilere göre özgüvenleri daha iyidir. Evde kaldığını beyan eden spor fakültesi öğrencilerinin yurtlarda kaldığını belirtenlerden daha iyi özgüvene sahip olmaları evde daha serbest hareket edebilmeleri yanında
iyi dinlenebilmeleri gibi nedenlere bağlanabilir. Spor fakültesinde eğitim gören öğrencilerin kalma yerlerinin sporcuların daha serbest hareket edebilmeleri ve dinlenebilmelerine uygun olacak şekilde düzenlenmesi önerilir.
Effect of Sowing Date and Phosphorus on Growth, Seed Yield and Quality of Fenugreek
Authors: Nahar Shamsun , Mostarin Tahmina , Khatun Khaleda , Akter Akhi , Begum Tahira , Shamim Abdullah Salfe Al , Mamun Faysal-Al , Imtiaz Abdullah All , Iqbal Mahbub , Samad Md. Abdus
Published: September 2022

The effect of sowing date (three sowing dates viz., S1= 01 November, S2= 15 November and S3= 30 November) and phosphorus levels (four phosphorus fertilizer levels viz., P0= Control, P1= 35 kg P ha-1, P2= 45 kg P ha-1 and P3= 55 kg P ha-1) on growth, seed yield and quality of fenugreek was investigated at Horticulture Farm, Sher-e-Bangla Agricultural University, Dhaka, Bangladesh, during 10 October 2020 to April 2021. Growth-related data was maximum on S1 (01 November) treatment but S2 (15 November) treatment showed the best result in case of seed yield. In case of growth characters, P3 (55 kg ha-1) revealed the best result but in case of seed yield, P2 (45 kg ha-1) treatment showed the best effect. Under this investigation, it was revealed that the maximum growth was obtained by S1P3 (01 November with 55 kg P ha-1) and the minimum growth was obtained by S3P0 (30 November with control) treatment combination. The maximum pods per plant (52.61), seeds per pod (12.87), weight of individual pod (147.11 mg), the weight of seeds per plant (7.67 g) and weight of 1000-seed (13.86 g), seed yield per plot (306.72 g), seed yield per hectare (2.13 t) and vigor index (570.27) was observed from the treatment combination S2P2 (15 November with 45 kg P ha-1). It was concluded that the combination of sowing date S2 (15 November) along with phosphorus application P2 (45 kg P ha-1) were given the better performance of all the yield contributing parameters and seed yield of fenugreek. So, S2P2 (15 November with 45 kg P ha-1) treatment combination can be repeated in different agro-ecological zones of Bangladesh.
An A‐form of poly[d(A‐C)] · poly[d(G‐T)] induced by mercury (II) as studied by UV and FTIR spectroscopies
Authors: Garriga Pere , Garcia-Quintana David , Manyosa Joan
Published: July 2002

The conformational changes of poly[d(A‐C)]·poly[d(GT)] induced by Hg(CiO4)2 in aqueous solution have been studied using UV absorption and fourth derivative spectrophotometries, and FTIR spectroscopy. The UV absorption and fourth derivative spectra reflect changes in the polynucleotide stacking interactions as a result of the metal‐polynucleotide interaction. The fourth derivative spectra do not indicate a Z‐form either at low or at high metal‐to‐polynucleotide ratios. Furthermore, the infrared spectrum at high metal‐to‐polynucleotide ratio has the main features of an A‐form, in contrast with previous CD studies which proposed that the polynucleotide adopts a Z‐form under these conditions. The nature of a different conformation of the polynucleotide induced at low r‐ratios (r < 0.2) is discussed.
DNA binding properties of the zinc‐bound and zinc‐free HIV nucleocapsid protein: supercoiled DNA unwinding and DNA‐protein cleavable complex formation
Authors: Priel Esther , Aflalo Esther , Seri Iftach , Henderson Louis E , Arthur Larry O , Aboud Mordechai , Segal Shraga , Blair Donald G
Published: July 2002

The HIV nucleocapsid (NC) protein contains, as those of other retroviruses, two Cys‐His arrays which function as zinc finger binding domains. The nucleic acid binding properties of retroviral NC have been previously demonstrated. In this study, we characterized the DNA binding ability of the zinc‐bound and zinc‐free forms of HIV NC. We found that in addition to binding single‐stranded DNA, both forms bind and unwind supercoiled plasmid DNA. The binding ability of the zinc‐bound form was higher than the zinc‐free form. In addition we showed the formation of NC protein‐DNA cleavable complex which is the result of a presumably covalent bond formed between the protein and the phosphate moiety of the DNA backbone. The NC unwinding activity and the protein‐DNA cleavable complex formation resembles the first step of the relaxing mechanism of DNA topoisomerase. Our results shed light on the possibility of a novel physiological function for the HIV NC protein in the viral life cycle.
Phosphorothioate oligonucleotides bind in a non sequence‐specific manner to the nucleolar protein C23/nucleolin
Authors: Weidner Douglas A. , Valdez Benigno C. , Henning Dale , Greenberg Scott , Busch Harris
Published: July 2002

To design optimal strategies for intracellular delivery of antisense phosphorothioate oligonucleotides, it may be useful to understand their interaction with cellular macromolecules. Nuclear extracts from LOX amelanotic myeloma cells were studied for protein binding to phosphorothioate oligonucleotides using a Southwestern protocol. Multiple nuclear proteins bound to the phosphorothioate oligonucleotides but no detectable protein binding was found to phosphodiester oligonucleotides. The protein with the strongest binding signals was shown by immunoprecipitation to be nucleolar C23/nucleolin, a 110 kDa protein. With glutathione S‐transferase/nucleolin fusion protein constructs, the region of nucleolin containing the RNA recognition motifs had binding activity to phosphorothioate oligonucleotides.
Heads or tails — what determines the orientation of proteins in the membrane
Authors: Spiess Martin
Published: July 2002

The same translocation machinery in the endoplasmic reticulum translocates either the N‐ or the C‐terminal domain of signal‐anchor proteins across the membranes. Charged residues flanking the signal sequence are important to determine which end is translocated, but are not sufficient to generate a uniform topology. The folding state of the N‐terminal segment, which is to be translocated posttranslationally, and the length or hydrophobicity of the signal sequence are additional criteria to determine protein orientation in the membrane.
Up‐regulation of protein serine/threonine phosphatase type 2C during 1α,25‐dihydroxyvitamin D3‐induced monocytic differentiation of leukemic HL‐60 cells
Authors: Nishikawa Masakatsu , Omay Serdar B. , Nakai Keiji , Kihira Hisakazu , Kobayashi Takayasu , Tamura Shinri , Shiku Hiroshi
Published: July 2002

Treatment with 20 nM 1α,25‐dihydroxyvitamin D3 (1,25(OH)2D3) caused a progressive increase in the activity of Mg2+‐dependent protein serine/threonine phosphatase type 2C (PP2C) in subcellular fractions of HL‐60 cells, whereas PP2C activity was relatively constant throughout all‐trans retinoic acid‐induced (1 μM) granulocytic differentiation. The increase in PP2C activity appeared to parallel the 1,25(OH)2D3‐induced phenotypic and functional changes in HL‐60 cells. Immunoblot and Northern blot analysis indicated that the increase in PP2C activity corresponded to the increased expression of PP2C protein, which was preceded by an increase in the level of mRNA for PP2Cβ. No mRNA for PP2Cα was detected in resting or 1,25(OH)2D3‐stimulated HL‐60 cells. These results suggest that the increased expression of PP2C is related with the 1,25(OH)2D3‐induced monocytic differentiation of HL‐60 cells.