bluuebunny/crossref_metadata_2025 huggingface dataset:
Concettualizzazioni cliniche e psicopatologiche degli esordi psicotici dalla seconda metà dell'800 ai nativi digitali
Authors: Dalle Luche Riccardo Piero
Published: August 2023

La vasta letteratura sulla psicopatologia adolescenziale e gli esordi psicotici ignora la storia delle categorie diagnostiche che nel corso di 150 anni si sono succedute nella concettualizzazione di questi quadri clinici. L'Autore riassume la vicenda che, attraverso una prima descrizione dell'Ebe- frenia, portò al costrutto di Dementia praecox e, successivamente, a quello di Schizofrenia ancora in uso. Successivamente analizza le principali descrizio- ni psicopatologiche dei quadri di esordio che si sono succedute nel ‘900, in particolare quello della Schizofrenie simplex polimorfa e delle Schizofrenie subapofaniche. Tutti questi modelli riservano ancora oggi elementi di grande validità didattica e facilitano il corretto riconoscimento degli esordi nella clinica di oggi, che appare spesso confuso e tardivo per una serie di motivi. Tra questi la crisi della nosografia, la concettualizzazione degli esordi psi- cotici nel modello del disturbo del neurosviluppo tardivo, con le numerose accertate comorbidità ed i cambiamenti nel corso del tempo, il polimorfismo e l'aspecificità sintomatologica, da ultimo i grandi cambiamenti degli stan- dard comportamentali e cognitivi dei nativi digitali che spesso mascherano o si sovrappongono ai sintomi. Appare necessario per gli psichiatri clinici una riconcettualizzazione appropriata di questi quadri il cui trattamento precoce è di fondamentale importanza per la vita dei giovani pazienti, potendo condi- zionare positivamente la prognosi sia a breve che a lungo termine.
Prestatori e mercato del credito in Valtellina: il caso di Chiuro alla fine del XIV secolo tra élite rurale e affermazione sociale
Authors: Piccardo Ilyes
Published: August 2023

Il saggio analizza le persone che sono coinvolte nel settore creditizio nella località di Chiu- ro, in Valtellina, nell'ultimo quarto del XIV secolo. Attraverso l'utilizzo della documentazione notarile, l'autore esamina i prestatori, le loro attività, le modalità del loro coinvolgimento nel mercato del credito e come essi si inseriscono nella dinamica piazza chiurese. Il saggio evidenzia l'affermazione del modello economico e sociale rappresentato dall'élite rurale. Il successo delle scelte economiche di questi notabili, anche attraverso gli atti di mutuo e i prestiti dietro ipoteca fondiaria, li rende il punto di riferimento per gli altri ceti sociali che cercano di arricchirsi. I mercanti, gli artigiani, i proprietari immobiliari e i con- tadini benestanti tentano di ripercorrere le medesime strategie economiche dell'élite locale, seppur con modalità differenti, dimostrando la proficuità dei prestiti e la loro utilità anche come mezzo di mobilità e di affermazione sociale.
Come lo spirito del tempo riadatta la storia: il caso dell'eccidio Rivolta a Monza dopo il Quarantotto
Authors: Coviello Lucia Grazia
Published: August 2023

Il ritorno degli austriaci, dopo la capitolazione di Milano il 5 agosto 1848, si è accompagnato all'adozione di una politica assai repressiva. A Monza il ripristino dell'assoluto e le misure gravose imposte alla popolazione provocano, almeno nelle settimane immedia- tamente successive alla chiusura della breve parentesi rivoluzionaria, manifestazioni di malcontento e di sfida verso l'autorità straniera. È in questo contesto di forte tensione dove la comunicazione fra occupanti e occupati procede tra l'emissione di divieti e dove- ri da un lato, relativi, almeno in questa prima fase, al controllo dell'ordine pubblico, e la violazione dall'altro, che ha luogo la fucilazione di Carlo e Pietro Rivolta, padre e figlio condannati a morte per il possesso di armi e munizioni. Questo saggio, nel ricostruire il clima cittadino antecedente e successivo all'eccidio, intende inoltre mostrare come la morte dei Rivolta, nell'Italia unitaria quanto in quella fascista e repubblicana, venga per certi aspetti snaturata rispetto al suo movente originario e resa assonante alle esigenze narrative delle epoche citate.
Pelestarian Aset Budaya Permainan Congkak Melalui Desain Karakter Untuk Anak
Authors: Sartika Vina Dwi , Wulandari Sri , Ayuswantana Alfian Candra
Published: August 2023

Permainan Tradisional kini semakin hilang disebabkan oleh adanya permainan dari bangsa asing yang banyak beredar dalam bentuk game online. Game yang mampu mengalihkan perhatian dan minat anak-anak terhadap permainan tradisional Indonesia. Melalui permainan anak-anak mampu merasakan berbagai perasaan gembira atau juga kesedihan, bermain juga melibatkan interaksi satu sama lain atau lawan. Untuk mencapai perasaan itu dapat ditemui dengan bermain permainan tradisional. Suasana tersebut dapat ditemui dalam permainan tradisional. Berdasarkan hal tersebut, penulis tertarik untuk merancang desain karakter tentang permaianan tradisional Indonesia yaitu permainan Congklak. Perancangan ini menggunakan metode penelitian kualitatif dengan Teknik pengambilan data berupa wawancara, observasi dan studi literatur. Hasil dalam perancangan ini berupa karakter animasi berbasis 2D yang nantinya akan diimplementasikan dalam berbagai media komunikasi. Perancangan desain karakter ini merupakan salah satu cara untuk melestarikan aset budaya asli Indonesia serta mengedukasi masyarakat tentang permainan tradisional agar eksistensinya tetap terjaga.
¿La arquitectura discursiva de las plataformas digitales influye en la participación política? Un estudio nacional diferenciado
Authors: Echeverría Martín , Bringas  Ramírez Adalid , Rodríguez-Estrada Alejandra
Published: August 2023

Investigamos el efecto de las redes sociodigitales en los tipos de participación cívica, política y en línea, tomando en cuenta la arquitectura discursiva y consecuente deliberatividad de cada plataforma, que hipotéticamente incrementa la participación. Primero analizamos la deliberatividad de las plataformas Facebook, Twitter y YouTube, y segundo, la medida en que estas predicen la participación, mediante una encuesta nacional (N = 1 750). Encontramos un efecto de las redes en su conjunto y efectos diferenciados de cada una en aquellos tipos de participación, pero sin vinculación con su grado de deliberatividad.
Assembling bodies-and-spaces: a conceptual approach to understanding midwives' perceptions of chest/breastfeeding families and the home environment
Authors: Currie Caroline
Published: August 2023

Chest/breastfeeding parents have consistently voiced their need for relational styles of perinatal care. This care is essential to the maintenance of breastfeeding long-term. Little Canadian research has focused on midwives’ support of families at home and their perceptions of how socio-physical environments affect chest/breastfeeding. This knowledge gap is important because up to 90% of Canadian people intend to breastfeed prenatally. Substantially less exclusively breastfeed their infants at 6 months of age. In this study, I drew on a postmodern conceptual framework to analyze, describe and interpret the accounts of six midwives and their perceptions of breastfeeding families at home. Findings illustrate that midwives support breastfeeding by participating in dynamic bodily encounters with families and creatively engage with spaces to enhance parent-infant togetherness after birth. Findings fill a critical gap in knowledge about these emergent, embodied relations and their impact on breastfeeding practices at home.
Detached Eddy Simulation of Unsteady Flow Past Square Cylinders
Authors: Dong Xiaojia
Published: August 2023

In this thesis, the Detached Eddy Simulation (DES), available in ANSYS-FLUENT) is employed to solve 2D unsteady flow over double cylinders in tandem for three different pitches and a Reynolds number of 22,000. With proper choice of mesh sizes and time steps, the DES is found to yield accurate results at affordable computing cost. Effects of pitch to diameter ratios on the lift and drag forces in the spatial and temporal domains are investigated. The simulation results are useful in studying cross-flow flow induced vibration of slender structures. 
Multi-Criteria Decision-Making Approach with Interval-Valued Intuitionistic Fuzzy Assessment for Green Supplier Evaluation and Selection
Authors: Hashsmi Bushra Ahsan
Published: August 2023

Becoming climate positive is the objective businesses, which have recently started to focus on and research about to curb the ever-increasing climate challenges while being profitable efficiently. In the pursuit of integrating environmental aspects into conventional supply chains, the concepts of green supply chain and supplier selection have emerged that become increasingly complex due to current economic globalization. In this research, we have proposed a green supplier selection methodology based on a comprehensive set of criteria and interval-valued intuitionistic fuzzy assessment of alternatives for realistic decisions. The three phases of the methodology constitute pertinent criteria selection incorporating environmental and social aspect, the assessment of alternatives in an interval-valued intuitionistic fuzzy environment through an integrated multi- criteria decision-making approach comprising best-worst method (BWM) and technique for order preference by similarity to ideal solution (TOPSIS) with cosine similarity measure and finally the sensitivity analysis. We have supported the proposed methodology by illustrative example considering a real-world scenario. 
Techno-Economic Feasibility of Wastewater Energy Transfer (WET) Systems for Cold Climates
Authors: Kwiatek Conrad
Published: August 2023

Wastewater is an abundant and underutilized source of thermal energy, that when coupled with heat exchangers and heat pumps, can provide heating and cooling to buildings. These Wastewater Energy Transfer (WET) systems can result in significant greenhouse gas (GHG) reductions compared to the conventional alternatives.

The Ryerson University campus buildings are used as a case study and are simulated using weather data for 6 major Canadian cities. A detailed energy model was developed that compared the performance of a conventional HVAC system to the WET system. Using local GHG emissions factors and utility rates, the model calculated the energy consumption, operating costs and GHG emission for both systems. A detailed financial model was developed to calculate the project internal rate of return (IRR) and equity returns. The financial results were used to determine the optimal size of the WET system for each city. For 5 of the 6 major Canadian cities considered, the WET system was able to achieve a project IRR of greater than 8%, which was considered to be the minimum acceptable rate of return for a financeable project. The WET systems resulted in annual savings ranging from $128,544 in Calgary up to $2,057,855 in Montreal with an average of $852,196. Annual GHG emissions reductions ranged from 5,464 tonnes in Winnipeg to 21 tonnes in Montreal, with an average of 2,235 tonnes.

A multi-unit residential building in Toronto, Canada was used as the case study to evaluate the viability of integrated WET systems with ambient-loop (AL) HVAC systems consisting of a series of dispersed heat pumps. An energy model was developed that calculated the performance of supplying the AL with conventional boilers and cooling towers, and compared it to supplying the AL with the WET system. The model calculated the annual energy consumption, operating costs and GHG emissions of both systems. Lastly, a financial model was developed to determine the project and equity returns of the WET AL system. The WET based AL system reduced electricity consumption by 8.2%, offset 516,410 m3 of natural gas and 4,655 m3 of water annually from evaporative cooling towers. The year 1 operating savings of the WET AL system were $156,911 and resulted in a project IRR of 9.10%. The annual GHG emissions reduction amounts to 991 tonnes, or approximately 89% of the emissions attributed to the HVAC system.
Exploring weight bias internalization in young women: a multi-methods approach
Authors: Friedman Aliza
Published: August 2023

 Weight bias internalization occurs when individuals accept negative societal weight- and shapebased attitudes and direct them towards themselves. Although this construct is typically explored among individuals with a higher body weight, there is a growing amount of evidence suggesting that weight-based stigma experiences and subsequent internalization occur across the weight spectrum. The overall aim of this dissertation was to better understand the construct of weight bias internalization in a group of individuals not typically conceptualized as being negatively impacted by weight-based stigma: young women predominantly in the normal-weight range. Study 1 (N = 196) examined correlates of weight bias internalization and other related internalization constructs (self-objectification, thin ideal internalization). Using a hierarchical multiple regression approach, weight bias internalization was found to predict measures of disordered eating (binge eating, emotional eating, and dietary restraint), body shape concerns, and psychological distress over and above the influences of the other internalization measures. These results potentially underscore the importance of assessing and treating weight bias internalization among young women; however, the high correlation between weight bias internalization and body shape concerns suggest that these variables may instead represent similar constructs. Study 2 built upon these findings by exploring the comparative effects of two strategies aimed at reducing weight bias internalization (teaching participants self- providing psychoeducation about weight regulation) and a control condition using a pre-post, single session study design. Participants (N = 123) demonstrating at least moderate levels of weight bias internalization on a pre-screen measure were randomly assigned to one of three conditions: Self-Compassion, Psychoeducation, or a Control condition. Relative to the Control group, participants in both active treatment conditions demonstrated significant reductions in weight bias internalization and improvements in appearance state self-esteem. Participants in the Psychoeducation condition also reported significantly lower endorsement of weight control beliefs (relative to both comparison groups) and significantly greater endorsement of healthy lifestyle beliefs (relative to the control group). Between-group differences in affect, body shape concerns, self-compassion, and fear of self-compassion were non-significant. These findings suggest that both enhancing self-compassion and providing accurate psychoeducation about weight regulation may help to reduce weight bias internalization among young women.   
Pengenalan Wajah 3D dengan menggunakan PointNet
Authors: Arif Hidayah  , Dewantara Bima Sena bayu , Pramadihanto Dadet
Published: August 2023

Pengenalan wajah tiga dimensi (3D) telah menjadi topik penelitian yang menarik karena mampu mengatasi keterbatasan pengenalan wajah dua dimensi (2D) dalam menghadapi perubahan pose, pencahayaan, dan pemalsuan. Penelitian ini mengusulkan sebuah pipeline pengenalan wajah 3D yang invarian terhadap perubahan cahaya, dengan menggunakan teknik segmentasi euclidean clustering dan Convolutional Neural Network (CNN) PointNet. Data wajah diambil menggunakan kamera Time-of-Flight yang menghasilkan titik awan (point cloud). Proses segmentasi euclidean clustering berhasil memisahkan area wajah dengan akurat, membantu dalam pengenalan wajah 3D. Melalui pelatihan dengan 217 dataset dan 2048 titik per wajah, sistem mencapai akurasi pelatihan sebesar 99% dan akurasi validasi sebesar 84,4%, dengan loss pelatihan sebesar 1% dan loss validasi sebesar 15,6%. Evaluasi pada tiap kelas menunjukkan rata-rata akurasi 0.9887471867966992, presisi 0.8255813953488372, recall 0.8255813953488372, dan F1-score 0.8255813953488372. Hasil menunjukkan bahwa pipeline pengenalan wajah 3D ini memiliki potensi besar dalam aplikasi keamanan, pengawasan, dan pengenalan objek di lingkungan yang kompleks.
 
Three-dimensional (3D) face recognition has emerged as an intriguing research topic, addressing the limitations of two-dimensional (2D) face recognition in handling pose variations, lighting changes, and spoofing. This study proposes an illumination-invariant pipeline for 3D face recognition, utilizing the euclidean clustering segmentation technique and Convolutional Neural Network (CNN) PointNet. Facial data is captured using a Time-of-Flight camera, generating point clouds. The euclidean clustering segmentation effectively isolates facial regions, aiding in 3D face recognition. After training with 217 datasets and 2048 points per face, the system achieved 99% training accuracy and 84.4% validation accuracy, with 1% training loss and 15.6% validation loss. Class-wise evaluation yielded an average accuracy of 0.9887471867966992, precision of 0.8255813953488372, recall of 0.8255813953488372, and F1-score of 0.8255813953488372. The results highlight the significant potential of this 3D face recognition pipeline in security, surveillance, and object recognition in complex environments.
Sistem Screening Mandiri Covid-19 Berbasis Internet of Things (IoT)
Authors: Gusti Agrippina Waya Rahmaning , Rokhana Rika , Kemalasari  , Ningsih Vita Kusuma
Published: August 2023

The increasing need to perform Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) during the COVID-19 pandemic is time-consuming and costly. An IoT-based self-screening system of COVID-19, is expected to be a solution. In this study, instruments were created to monitor SpO2 and heart rate using the MAX30102 sensor, body temperature using the MLX90614 sensor, and breathing rate using a flex sensor as a COVID-19 detection parameter. The measured vital sign results are also transmitted to the website using the Wi-Fi module ESP32. The method used is a decision tree that has two classifications, indicated healthy and indicated COVID-19. Decision tree accuracy is 90% and recall is 100%. Temperature readings have a 98.68% accuracy, SpO2 readings and heartbeats are 98.74% and 98.64%, respectively, and breathing rate per minute readings are 100% accurate. This autonomous COVID-19 screening system can be used as an alternative solution for early detection of COVID-19.
Development of Print Modules into Electronic Modules in Food Microbiology Courses
Authors: Rosel Ruhul Fitri Rosel , Faridah Anni , Kasmita  , Ambiyar
Published: August 2023

Food microbiology is one of the compulsory and important subjects as a basis for advanced courses such asFood Control, Food Preservation and Food Technology. Students experience difficulties in understanding learning material because there is no valid and practical media to use. To overcome this problem, media development was carried out in the form of E-modules for Food Microbiology Courses. The aim of this research is to develop E-module on Food Microbiology course in terms of material, format and presentation. This research uses the methodResearch and Development. E-module development using 4D models. Number of test validatorsvalidity 6 lecturers, consisting of 3 media test validator lecturers and 3 material test validator lecturersas well as 27 students majoring in Culinary Management. The average result of the assessment of material validation is 0.84 with the Valid category. Data were analyzed using the Aiken's V formula. The average result of the E-module validation assessment was 0.85 in the Valid category. The overall average result of the E-module validation on Food Microbiology Course is 0.84 with the Valid category. The average percentage of practicality by lecturers is 86.3% in the very practical category while the average practicality by students is 83.29% in the very practical category. Based on the results of all analyzes canconcluded E-module Food Microbiology Course is suitable for use in learning.
Enhancing Gaming Engagement through the Integration of Game Design Document and Finite State Machine: A Study on Optimizing Non-playable Character Responsiveness
Authors: Wiratama Jansen , Rian  , Evelin Johan Monika , Santoso Hari
Published: August 2023

Non-playable Character (NPC) is a prominent terminology within the gaming domain. While players do not directly control NPCs, their role significantly influences the gaming experience. Enhancing NPC responsiveness becomes imperative as NPCs' passive nature can lead to monotonous gameplay. To address this concern, a computational model, namely Finite State Machine (FSM), is implemented to elevate NPC responsiveness during interactions with the main characters, whether as adversaries or allies. This research uses the Game Design Document (GDD) methodology to design a survival horror-themed game. The resultant Survival Horror Game undergoes Alpha testing to validate its overall functionality and the successful integration of the FSM computational model. Findings indicate that enemy NPCs can pursue the main character from any position, with an average arrival interval of 68 seconds. Additionally, allied NPCs promptly respond when the main character approaches. Subsequently, the Beta testing results reflect an 80% average score interpretation based on percentage responses, implying the game's favorable suitability and acceptability on the Likert scale.
A Comparative Study of Computer Programming Challenges of Computing and Non-Computing First-Year Students
Authors: Mbiada Alain , Isong Bassey , Lugayizi Francis
Published: August 2023

The learning of computer programming comes with unique difficulties that vary among students depending on their backgrounds, learning methods, and objectives. This paper investigates the programming challenges first-year students from non-computing at the North-West University, South Africa, and computing backgrounds at the University of Dschang, Cameroon face. A questionnaire-based data collection method is utilized and categorizes participants based on their gender, age, fields of study, prior experiences in mathematics, statistics, English, and programming languages, lab use/access, learning strategies, and material preferences. The aim is to identify and analyze the student's understanding of the basic programming concepts and the specific challenges met during introductory programming modules. Analysis of the collected data shows that while a considerable percentage of non-computing students have prior experience in mathematics and English, they lack familiarity with programming. Equally, while most computing students are proficient in spoken English, they face significant challenges in programming, mathematics, and written English. Notable difficulties are experienced in grasping concepts like recursion, arrays, error handling, and function/procedure methods. Moreover, a comparative study reveals that both groups of students encounter similar challenges, however, non-computing students’ difficulties are more than their computing counterparts. This paper, therefore, suggests designing teaching methods and learning materials to specifically meet the needs of non-computer science students, and enhance their understanding and proficiency in computer programming.
Myeloid lineage switch in KMT2A-rearranged acute lymphoblastic leukemia treated with lymphoid lineage-directed therapies
Authors: Bataller Alex , Abuasab Tareq , McCall David , Wang Wei , Cuglievan Branko , Issa Ghayas C. , Jabbour Elias , Short Nicholas , DiNardo Courtney D. , Tang Guilin , Garcia-Manero Guillermo , Kantarjian Hagop M. , Sasaki Koji
Published: August 2023

Not available.
Albayrak Gazetesinin Kapatılması Üzerine Görüşler
Authors: ŞAVKILI Cengiz , AKYILDIZ Ali
Published: August 2023

Albayrak gazetesi Milli Mücadele döneminde Erzurum’da yayın yapan önemli gazetelerinden biridir. Albayrak’ın baş yazarı ve sorumlu müdürü Mithat Bey 21 Şubat 1921 tarihindeki “Emel ve Fikir Birliği” başlıklı makalesinden ötürü kovuşturmaya tabi tutulmuştur. Söz konusu kovuşturma ile birlikte Albayrak gazetesi kapanmıştır. Gazetenin kapanması bazı tartışmaları beraberinde getirmiştir. Gazetenin kapatılmasına sebep olarak Halk Hükümeti kurma girişimi, İttihatçı etkisinde kalma ve komünizm fikri etkisinde yayın yapma iddiaları gösterilmiştir. Makalede bu iddialar ele alınarak değerlendirilmiştir. Albayrak’ın kapatılmasının en önemli sebebinin komünist fikir etkisinde yayın yapması nedeniyle gerçekleştiği sonucuna ulaşılmıştır. Çalışmada arşiv kaynakları, gazeteler ve kaynak eserlerden faydalanılmıştır.
Disease vector occurrence and ecological characteristics of chiggers on the chestnut white-bellied rat Niviventer fulvescens in Southwest China between 2001 and 2019
Authors: Chen Yan-Ling , Guo Xian-Guo , Song Wen-Yu , Ren Tian-Guang , Zhang Lei , Fan Rong , Zhao Cheng-Fu , Zhang Zhi-Wei , Dong Wen-Ge , Huang Xiao-Bin , Jin Dao-Chao
Published: August 2023

Chigger mites are the vector of scrub typhus. This study estimates the infestation status and ecological characteristics of chiggers on the chestnut white-bellied rat Niviventer fulvescens in Southwest China between 2001 and 2019. Chiggers were identified under the microscope, and infestation indices were calculated. The Preston’s log-normal model was used to fit the curve of species abundance distribution. A total of 6,557 chiggers were collected in 136 of 342 N. fulvescens rats, showing high overall infestation indices (prevalence=39.8%, mean abundance=19.2, mean intensity=48.2) and high species diversity (S=100, H’=3.0). Leptotrombidium cangjiangense, Neotrombicula japonica, and Ascoschoengastia sifanga were the three dominant chigger species (constituent ratio=42.9%; 2,736/6,384) and exhibited an aggregated distribution among different rat individuals. We identified 100 chigger species, with 3 of them (Leptotrombidium scutellare, Leptotrombidium wenense, and Leptotrombidium deliense) as the main vectors of scrub typhus in China and nine species as potential vectors of this disease. Disease vector occurrence on N. fulvescens may increase the risk of spreading scrub typhus from rats to humans. Chigger infestation on N. fulvescens varied significantly in different environments. The species abundance distribution showed a log-normal distribution pattern. The estimated number of chigger species on N. fulvescens was 126 species.
Phylogenetic and phylogeographic analyses of Anisakis simplex sensu stricto (Nematoda: Anisakidae) from the common minke whale in Korean waters
Authors: Kim Sunmin , Lee Bom Sok , Choe Seongjun
Published: August 2023

The genus Anisakis is among the most significant parasites to public health, as it causes anisakiasis, a parasitic infection in humans resulting from consuming raw or undercooked seafood. Although the infection status of i>Anisakis in second intermediate hosts, such as marine fishes and cephalopods, and humans have been severally reported in Korea, no information about the definitive host in Korean waters is available. In 2014, 2 adult gastric nematodes were collected from a common minke whale (Balaenoptera acutorostrata) found in the East Sea, Korea. These worms were identified as A. simplex sensu stricto (s.s.) by comparing the mitochondrial COX2 marker with previously deposited sequences. Phylogenetic and phylogeographic analyses of A. simplex (s.s.) worldwide revealed 2 distinct populations: the Pacific population and the European waters population. This is the first report on adult i>Anisakis and its definitive host species in Korea. Further studies on Anisakis infection in other cetacean species and marine mammals in Korean seas are warrantedi>Anisakis
A case of hepatic anisakidosis caused by Anisakis pegreffii mimicking liver cancer
Authors: Yamada Minoru , Murakoshi Fumi , Ikoma Hisashi , Inamori Osamu , Yanagisawa Akio , Konishi Eiichi
Published: August 2023

Extra-gastrointestinal anisakidosis is rare. We herein report an Anisakis pegreffii infection in a patient with hepatic anisakidosis diagnosed based on its molecular identification. A 71-year-old male patient had a hepatic tumor presenting as a low-density area of 20 mm in diameter in segment 6 of the liver on abdominal ultrasonography, computed tomography, and magnetic resonance imaging. The surgically resected pathological specimen revealed a necrotizing eosinophilic granuloma containing nematode larvae, possibly an Anisakis larva. Molecular and phylogenetic analysis demonstrated Anisakis larvae belonging to A. pegreffii. The present results will help identify and characterize unknown Anisakis species in histological sections.
Prens Muhammed bin Selman’ın 2030 Vizyonunu Anlamlandırmak: Suudi Arabistan’da Teknokrasi, Milliyetçilik ve Yeni Ekonomi
Authors: ÇINKARA Gökhan
Published: August 2023

Suudi Arabistan, Arap Baharı sonrasında toplumsal, siyasî ve iktisadî boyutlarda dönüşüm sürecine girmiştir. Bu aşamayı başlatan gelişme Prens Muhammed bin Selman'ın (MbS) Veliaht pozisyonuna getirilmesidir. Çok yönlü ve kapsamlı modernleşme sürecine giren Suudi Arabistan'ın bu gelişmeleri hangi dinamikler üzerinden ilerlettiği sorusu önemlidir. Bu çalışma 2030 Vizyonu etrafında şekillenen Suudi Arabistan'ın modernleşmesini üçlü ve birbirine bağlı geniş ve yapısal dönüşümler üzerine oturtmaktadır: Toplum düzeyinde dönüşüm milliyetçiliğin yükselişiyle ilerlemekte; siyaset düzeyinde değişim teknokrat kadroların yönetici elit pozisyonuna gelmesiyle şekillenmekte ve ekonomi düzeyinde farklı bir rotaya girilmesi ise petrol-sonrası ekonomiye geçiş çabalarında görülmektedir.

Suudi Arabistan’da yönetici elitler ülkenin değişen demografisi, dinamik bölgesel jeopolitik ve küresel ekonomik gelişmeler etrafında 2030 Vizyonunu yerlici bir modernleşme projesi olarak benimsemişlerdir. Lider bağımlı olan bu sürecin özelde Suudi Arabistan genelde ise bölgesel düzlemde ideolojik, ekonomik ve jeopolitik yansımalarının olacağı beklenmektedir.

Suudi Arabistan elitleri ve toplumsal sektörleri ile değişen demografi, yükselen yeni bölgesel siyasal eğilimler ve küresel siyasette pozisyonunu güncelleme arzusu arasında eskiden kopuş yeniye ise uyum sağlama arasında kapsamlı bir dönüşüm döngüsü içerisindedir. Prens MbS’in monarşi içerisindeki dengeleri gözetmesi öte yandan toplumun geleneksel sektörlerinin statü aşınmalarını yeni toplumsal aktörlerle (gençler, kadınlar ve beyaz yakalı çalışanlar) ikame etmesi 2030 Vizyonuna görece risk oluşturabilir. Bu çalışma 2030 Vizyonunun riskler ve fırsatlar etrafında şekillenen sürecini vizyonun üçlü rotası etrafında (teknokrasi, milliyetçilik ve yeni ekonomi) irdelemektedir.
Gelin Kaynana İlişkisinde Akrabalık Bağının Yeri ve Rolü
Authors: ÇAKIR Şule
Published: August 2023

Türk aile yapısı içinde gelin-kaynana ilişkisinin önemi yadsınamaz bir gerçektir. Öyle ki bu ilişkinin sağlıklı ilerleyemediği durumlarda evliliklerin bitmesine neden olduğu bilinmektedir. Gelin-kaynana ilişkisini belirleyen; tarafların eğitim düzeyi, gelir düzeyi, maddi manevi sermaye, kültür düzeyi, kuşak farkı gibi pek çok etken olmakla birlikte bu çalışmada bu ilişkinin gidişatında akrabalık bağının etkisi incelenmiştir. Akrabalık bağı bulunan gelin kaynanalar ile akrabalık ilişkisi bulunmayan gelin kaynanalar arasındaki ilişkinin niteliği ortaya konulmaya çalışılmıştır. Akrabalık bağının beraberinde “yakınlık” kavramı ile özdeşleştirilmesi ve yakınlık kavramının da sınır tanımazlık olarak algılanması ile gelin-kaynana ilişkisinin nasıl kaotik hal aldığı ele alınmıştır. Akrabalık bağının avantaj mı dezavantaj mı olduğu örneklerle ortaya konulmaya çalışılmıştır. Kaynak kişi görüşmeleri gelinlerle yapılmış olup çalışmanın kuramsal alt yapısı Feminist teori bağlamında oluşturulmuştur.
Risk Toplumu Bağlamında Covid-19 Pandemisinin Öğretmenlerin Gündelik Yaşamlarına Etkileri Üzerine Bir İnceleme
Authors: TAŞ Levent
Published: August 2023

Bu çalışmanın konusu Covid-19 pandemisinin öğretmenlerin yaşamındaki etkileridir. Salgının küresel çapta etkileri olmuştur. İnsan hayatını ve toplumsal yaşamı tehdit etmesi acil önlemleri gerektirmiştir. Pandemiyi engellemeye yönelik sokağa çıkma kısıtlamaları, sosyal mesafe kuralı, maske zorunluluğu, ticarethanelerin kapatılması, yüz yüze eğitimin durdurulması gibi birçok önlem alınmıştır. Bu önlemler toplumsal yaşamda ani değişmelere neden olmuştur. Bütün toplum gibi öğretmenlerin gündelik yaşamı da bu süreçten etkilemiştir. Bu çalışmada pandeminin öğretmenlerin yaşamındaki etkilerini açıklanması amaçlanmaktadır. Bu amaçla risk toplumu ile ilgili teorilerden hareket edilmektedir. Bu görüşler bağlamında Covid-19 pandemisi küresel bir risk olarak kabul edilmiştir. Çalışmada Covid-19 pandemisinin öğretmenlerin yaşamına etkileri risk algısı ve riskin gündelik yaşama etkileri olmak üzere iki kategoride ele alınmaktadır. Risk algısı çerçevesinde öğretmenlerin salgın hakkındaki düşünceleri ve bu düşüncelerdeki farklılıkların ortaya konulması amaçlanmaktadır. Gündelik yaşama etkilerin değerlendirilmesinde ise risklerin öğretmenlerin günlük yaşamlarındaki olumlu ve olumsuz yansımaları incelenmektedir. Araştırmada nicel betimsel araştırma benimsenmiştir. Araştırmanın verileri açık ve kapalı uçlu sorulardan oluşan soru formu ile toplanmıştır. Soru formunun uygulanması google forms aracılığıyla internet üzerinden yapılmıştır. Toplamda 210 katılımcı soru formunu yanıtlamıştır. Ancak 188 katılımcının formu analize dahil edilmiştir. Verilerin analiz edilmesinde SPSS-25 programı kullanılmıştır. Araştırma sonucunda öğretmenlerin gündelik yaşamlarında olumlu ve olumsuz etkilerinin olduğu görülmüştür. Olumsuz etkiler sosyal ilişkilerin ve sosyalliğin azalması, korku, kaygı ve stresin artması, hareketsizliğe bağlı sağlık sorunları gibi etkilerdir. Buna karşılık olumlu etkiler ise yaşama karşı farkındalığın artması, hobilere vakit ayırma, aile ile daha çok vakit geçirme şeklinde ortaya çıkmıştır. Bu çalışmanın sonuçları Covid-19 pandemisi örneğinde risklerin öğretmenlerin gündelik hayatlarında benlik ve kimlik inşasında etkileri olduğunu göstermektedir.
Sıraç Alevilerinde Orta Çağ Tarikatlarından Yesevîlik ve Bektaşilik İzleri: Hafik Beydili ve Tokat Hubyâr Örneği
Authors: MAZLUM Ahmet , GÜRTAŞ DÜNDAR Derya
Published: August 2023

Son yılların gerek akademide gerekse akademi dışındaki entelektüel camiada en çok ele alınan, tartışılan, farklı bakış açılarıyla ortaya konulmaya çalışılan konulan konulardan bir tanesi de Alevilik konusudur. Bazı çalışmalar Aleviliğin inanç boyutu üzerine odaklanırken, bazı çalışmalar da Aleviliğin siyasal boyutunu irdelemektedir. Günümüzde Alisiz Alevilik, Aleviliğin bir mezhep olmayıp siyasal bir itiraz olduğu, Cumhuriyetin kuruluşuyla birlikte kentlileşen bir yaşam tarzı olduğu, diğer yandan da Aleviliğin Orta Asya Şaman Türklüğünün günümüze kadar ulaşmış biçimi olduğu konuları bu tartışmaların odak konusunu oluşturmaktadır.

Bu çalışmanın amacı bahsedilen bu tartışma konularına angaje olmak değildir. Aleviliği verili bir durum kabul ederek tasavvuf ve inanç boyutundaki Ortodoksi diyebileceğimiz ibadet ritüellerini spesifik bir grup olarak Sıraç ve Hubyar Alevileri üzerinden değerlendirme amacındadır. Avrupa, Orta çağ döneminin Kilise karanlığını yaşarken Anadolu’da Ahmet Yesevî (11. ve 12. yüzyılda yaşamış) ve Hacı Bektaş-ı Veli gibi düşünür ve dinsel önderler daha hümanist ve kadın-erkek ilişkisi anlamında daha eşitlikçi bir görüşü temsil ediyordu. Bu iki düşünürün görüşleri ve dinsel önerileri günümüzde Sivas Beydili Sıraç Alevileri ve Tokat yöresi Hubyar Alevileri tarafından sıkı bir biçimde uygulanmaktadır. Ortodoksi bir katılıkta uygulanan bu ibadet ritüelleri çalışmanın temel konusunu oluşturmaktadır.

Metodolojik olarak tarihsel süreç içerisindeki gelişim değerlendirilmiş ve Orta çağda yaşamış bu düşünürlerin günümüzdeki dinsel varislerinin bu konudaki inanç ve uygulamaları ele alınmıştır. Bu çalışma nitel araştırıma deseni olan Odak Grup görüşmesi kullanılarak gerçekleştirilmiştir. Ahmet Yesevî ve Hacı Bektaş-ı Veli geleneğini sürdüren Sıraç Alevilerinden, farklı illerde yaşayan 8 kişi ile yüz yüze ve telefonla görüşme yapılmıştır. Katılımcıların görüş ve düşünceleri aktarıldıktan sonra zaman zaman tarihsel karşılaştırmalar yapılarak bahsedilen geleneğin günümüzde ne kadar sürdürüldüğü ortaya konulmaya çalışmıştır.
Advances in the application of recombinase-aided amplification combined with CRISPR-Cas technology in quick detection of pathogenic microbes
Authors: Li Xiaoping , Zhu Shuying , Zhang Xinling , Ren Yanli , He Jing , Zhou Jiawei , Yin Liliang , Wang Gang , Zhong Tian , Wang Ling , Xiao Ying , Zhu Chunying , Yin Chengliang , Yu Xi
Published: August 2023

The rapid diagnosis of pathogenic infections plays a vital role in disease prevention, control, and public health safety. Recombinase-aided amplification (RAA) is an innovative isothermal nucleic acid amplification technology capable of fast DNA or RNA amplification at low temperatures. RAA offers advantages such as simplicity, speed, precision, energy efficiency, and convenient operation. This technology relies on four essential components: recombinase, single-stranded DNA-binding protein (SSB), DNA polymerase, and deoxyribonucleoside triphosphates, which collectively replace the laborious thermal cycling process of traditional polymerase chain reaction (PCR). In recent years, the CRISPR-Cas (clustered regularly interspaced short palindromic repeats-associated proteins) system, a groundbreaking genome engineering tool, has garnered widespread attention across biotechnology, agriculture, and medicine. Increasingly, researchers have integrated the recombinase polymerase amplification system (or RAA system) with CRISPR technology, enabling more convenient and intuitive determination of detection results. This integration has significantly expanded the application of RAA in pathogen detection. The step-by-step operation of these two systems has been successfully employed for molecular diagnosis of pathogenic microbes, while the single-tube one-step method holds promise for efficient pathogen detection. This paper provides a comprehensive review of RAA combined with CRISPR-Cas and its applications in pathogen detection, aiming to serve as a valuable reference for further research in related fields.
Musculoskeletal simulation of professional ski jumpers during take-off considering aerodynamic forces
Authors: Huang Yi , Jiang Liang , Chen Xue , Sun Qing , Zhang Xiao , Tan Xunan , Du Yan , Zhang Fangtong , Wang Nannan , Su Rufeng , Qu Feng , Zhang Guoqing , Huo Bo
Published: August 2023

Introduction: Musculoskeletal simulation has been widely used to analyze athletes’ movements in various competitive sports, but never in ski jumping. Aerodynamic forces during ski jumping take-off have been difficult to account for in dynamic simulation. The purpose of this study was to establish an efficient approach of musculoskeletal simulation of ski jumping take-off considering aerodynamic forces and to analyze the muscle function and activity.

Methods: Camera-based marker-less motion capture was implemented to measure the take-off kinematics of eight professional jumpers. A suitable full-body musculoskeletal model was constructed for the simulation. A method based on inverse dynamics iteration was developed and validated to estimate the take-off ground reaction force. The aerodynamic forces, which were calculated based on body kinematics and computational fluid dynamics simulations, were exerted on the musculoskeletal model as external forces. The activation and joint torque contributions of lower extremity muscles were calculated through static optimization.

Results: The estimated take-off ground reaction forces show similar trend with the results from past studies. Although overall inconsistencies between simulated muscle activation and EMG from previous studies were observed, it is worth noting that the activation of the tibialis anterior, gluteus maximus, and long head of the biceps femoris was similar to specific EMG results. Among lower extremity extensors, soleus, vastus lateralis, biceps femoris long head, gluteus maximus, and semimembranosus showed high levels of activation and joint extension torque contribution.

Discussion: Results of this study advanced the understanding of muscle action during ski jumping take-off. The simulation approach we developed may help guide the physical training of jumpers for improved take-off performance and can also be extended to other phases of ski jumping.
The role of tyrosine in protein-dopamine based bioinspired adhesives: the stoichiometry that maximizes bonding strength
Authors: Lo Presti Marco , Ostrovsky-Snider Nicholas , Rizzo Giorgio , Portoghese Marina , Blasi Davide , Farinola Gianluca M. , Omenetto Fiorenzo G.
Published: August 2023

Nature has evolved adhesive materials adaptive for several different environments by using versatile chemistry that largely relies on two simple components: catechols and polypeptides. Herein, using dopamine as a catechol compound and several model proteins, we show how the adhesive properties can be tuned by controlling the ratio between catechol units and the tyrosine amino acid residue in the protein components. We found that the best bonding strength performance is obtained using a dopamine molar excess to tyrosine of 8.6 ± 2.9. Our study points out a general design criterion and process to obtain high-performance adhesives (>2 MPa) starting from cheap, commercially available, and sustainable raw materials.
Shaping the future of Ethereum: exploring energy consumption in Proof-of-Work and Proof-of-Stake consensus
Authors: Asif Rameez , Hassan Syed Raheel
Published: August 2023

Ethereum (ETH) is a popular Layer-1 blockchain platform that has been used to create decentralized applications (dApps) and smart contracts. Ethereum 2.0, or Serenity, is a significant update to the network that intends to address numerous issues with scalability, security, and energy efficiency. The Proof-of-Stake (PoS) consensus method will replace the Proof-of-Work (PoW) mechanism, which is one of the major new features of Ethereum 2.0. Given that PoS doesn’t require miners to do intensive mathematical calculations in order to validate transactions, it has the potential to be more energy-efficient than PoW. Additionally, this Ethereum upgrade will also be more secure due to the introduction of a new mechanism called “Casper” that will ensure that validators are always in agreement on the state of the blockchain. The paper begins by discussing the current issues facing Ethereum, including the limitations of the Proof of Work (PoW) consensus mechanism and the need for more efficient and scalable solutions. In this study, we peered at the major changes introduced by Ethereum 2.0, such as the new consensus method (Proof-of-Stake) and the addition of shard chains (Ethereum 2.0), as well as the associated development timelines, benefits and the community criticism on this upgrade.
Regulation of adult stem cell function by ketone bodies
Authors: Andersen Ole Emil , Poulsen Jens Vase , Farup Jean , de Morree Antoine
Published: August 2023

Adult stem cells play key roles in tissue homeostasis and regeneration. Recent evidence suggests that dietary interventions can significantly impact adult stem cell function. Some of these effects depend on ketone bodies. Adult stem cells could therefore potentially be manipulated through dietary regimens or exogenous ketone body supplementation, a possibility with significant implications for regenerative medicine. In this review we discuss recent findings of the mechanisms by which ketone bodies could influence adult stem cells, including ketogenesis in adult stem cells, uptake and transport of circulating ketone bodies, receptor-mediated signaling, and changes to cellular metabolism. We also discuss the potential effects of ketone bodies on intracellular processes such as protein acetylation and post-transcriptional control of gene expression. The exploration of mechanisms underlying the effects of ketone bodies on stem cell function reveals potential therapeutic targets for tissue regeneration and age-related diseases and suggests future research directions in the field of ketone bodies and stem cells.
Early expansion of activated adaptive but also exhausted NK cells during acute severe SARS-CoV-2 infection
Authors: Claus Maren , Pieris Naomi , Urlaub Doris , Bröde Peter , Schaaf Bernhard , Durak Deniz , Renken Frank , Watzl Carsten
Published: August 2023

The analysis of immunological parameters during the course of a SARS-CoV-2 infection is of great importance, both to identify diagnostic markers for the risk of a severe course of COVID-19, and to better understand the role of the immune system during the infection. By using multicolor flow cytometry we compared the phenotype of Natural Killer (NK) cells from hospitalized COVID-19 patients during early SARS-CoV-2 infection with samples from recovered and SARS-CoV-2 naïve subjects. Unsupervised high-dimensional analysis of 28-color flow cytometric data revealed a strong enrichment of NKG2C expressing NK cells in response to the acute viral infection. In addition, we found an overrepresentation of highly activated NK cell subsets with an exhausted phenotype. Moreover, our data show long-lasting phenotypic changes within the NK cell compartment that did not completely reverse up to 2 months after recovery. This demonstrates that NK cells are involved in the early innate immune response against SARS-CoV-2.
Plasma myeloperoxidase: association with atrial fibrillation progression and recurrence after catheter ablation
Authors: Liu Jingmeng , Lin Changjian , Zhou Taojie , Bao Yangyang , Xie Yun , Wei Yue , Luo Qingzhi , Ling Tianyou , Pan Wenqi , Zhang Ning , Lu Lin , Wu Liqun , Jin Qi
Published: August 2023

Background

Myeloperoxidase (MPO), released by activated neutrophils, is significantly increased in atrial fibrillation (AF). MPO may play a role in the progression of atrial fibrillation and further involved in AF recurrence after catheter ablation. We compared plasma MPO levels in paroxysmal and persistent AF and explored their role in AF recurrence after catheter ablation.

Methods

Plasma MPO levels were measured in consecutive patients with paroxysmal AF (n = 225) and persistent AF (n = 106). Samples of patients were collected from the femoral vein during catheter ablation and all patients included were followed up after catheter ablation.

Results

Plasma MPO levels increased from paroxysmal AF to persistent AF patients (56.31 [40.33–73.51] vs. 64.11 [48.65–81.11] ng/ml, p < 0.001). MPO significantly correlated with left atrium volume (LAV) and there existed a significant interaction between the two in relation to AF recurrence (p for interaction <0.05). During a median follow-up of 14 months, 28 patients with paroxysmal AF (12.44%) and 27 patients with persistent AF (25.47%) presented with recurrence after catheter ablation. The percentage of recurrence increased stepwise with increasing tertiles of MPO levels in both paroxysmal AF and persistent AF. MPO levels remained independently associated with AF recurrence after adjusting for potential confounding variables.

Conclusion

MPO levels were higher in persistent AF than in paroxysmal AF and MPO was positively correlated with LAV in AF. Elevated MPO levels may predispose a switch in AF phenotype and AF recurrence after catheter ablation.