bluuebunny/crossref_metadata_2025 huggingface dataset:
Co-creation and Evaluation of Nationwide Remote Training Service for Mental Health Education of Community Health Workers in Rwanda
Authors: Willems Annik , Iyamuremye Jean-Damascène , Misage Claire Nancy , Smith-Swintosky Virginia , Kayiteshonga Yvonne
Published: August 2021

Objective: Johnson & Johnson Global Public Health and the Ministry of Health of Rwanda strengthened the mental health awareness by providing an innovative, low-cost, easily accessible, and scalable remote training service (RTS) on mental health for Community Health Workers (CHWs).

Methods: The RTS consisted of eight training modules shared via simple feature phones over a 4-week period. Quiz questions and baseline/endline assessments were included to assess the feasibility and acceptability of the training platform, the knowledge and self-confidence gained by the CHWs, and prospects for the sustainability of the platform.

Results: Ninety-three percent of the CHWs completed at least four of the eight training modules, and 42% of the CHWs improved with a higher end score. The training content was considered interesting, easy to understand, and helpful to intervene appropriately to refer patients with signs of mental illness to a hospital and to provide community and family education on mental health topics.

Conclusion: The RTS is feasible and acceptable for the delivery of mental health training on a large scale and contributed to strengthening the capacity in delivering mental health care at community level.
The Contribution of Digital Health in the Response to Covid-19 in Vietnam
Authors: Bui Long Viet , Ha Son Thai , Nguyen Ha Ngoc , Nguyen Truong Thanh , Nguyen Thuy Phuong , Tran Kien , Tran Tuyen Van , Nguyen Tu Huu , Tran Thong Huy , Pham Nghiem Duc , Bui Hanh My
Published: August 2021

Emerging from early of 2020, the COVID-19 pandemic has become one of the most serious health crisis globally. In response to such threat, a wide range of digital health applications has been deployed in Vietnam to strengthen surveillance, risk communication, diagnosis, and treatment of COVID-19. Digital health has brought enormous benefits to the fight against COVID-19, however, numerous constrains in digital health application remain. Lack of strong governance of digital health development and deployment; insufficient infrastructure and staff capacity for digital health application are among the main drawbacks. Despite several outstanding problems, digital health is expected to contribute to reducing the spread, improving the effectiveness of pandemic control, and adding to the dramatic transformation of the health system the post-COVID era.
The Holistic Health Status of Chinese Homosexual and Bisexual Adults: A Scoping Review
Authors: Wu Chanchan , Choi Edmond Pui Hang , Chau Pui Hing
Published: August 2021

Background: Same-sex marriage is currently not legalized in China, despite the considerably large number of homosexual and bisexual Chinese populations. At the same time, their holistic health status remains unclear. This is the first scoping review conducted to comprehensively examine all the available literature and map existing evidence on the holistic health of homosexual and bisexual Chinese.

Methods: This scoping review used the framework of Arksey and O'Malley and followed the Preferred Reporting Items for Systematic Review and Meta-Analysis extension for scoping reviews (PRISMA-ScR). A comprehensive search strategy was carried out across 20 English (EN) and Chinese (both traditional and simplified) electronic databases from January 1, 2001, to May 31, 2020. Two reviewers conducted the reference screening and study selection independently and consulted a third senior reviewer whenever a consensus must be achieved. Data extraction was conducted using a structured data form based on the Cochrane template, after which a narrative synthesis of the findings was performed.

Results: A total of 2,879 references were included in the final analysis, with 2,478 research articles, 167 reviews, and 234 theses. Regarding the study populations, the vast majority of studies centered on men only (96.46%), especially men who have sex with men (MSM). Only 1.32% of the studies targeted female sexual minorities. The geographical distribution of all research sites was uneven, with most of them being conducted in mainland China (95.96%), followed by Hong Kong (2.05%), Taiwan (2.02%), and Macau (0.06%). Regarding the specific study focus in terms of the health domain, around half of the studies (45.93%) focused on sexual health only, and an additional quarter of the studies (24.15%) investigated both sexual health and social well-being. Meanwhile, the studies focusing on mental health only accounted for approximately 15% of the total.

Conclusions: This scoping review revealed that previous research focused more on male than female sexual minorities, on disease-centered surveys than person-centered interventions, and investigations on negative health conditions than positive health promotion. Therefore, investigations centered on the female sexual minorities and corresponding person-centered interventions are highly needed.

Review Registration: The protocol of this review has been registered within Open Science Framework (https://osf.io/82r7z) on April 27, 2020.
Urban Ecological Restoration: Setting Priorities for Restoring Native Vegetation in Lava Field Remnants in Mexico City
Authors: Bonilla-Rodríguez Manuel , Arroyo-Lambaer Denise , Castillo Alicia , Zambrano Luis , Cano-Santana Zenón
Published: August 2021

As cities overgrow, the need for ecological restoration is becoming increasingly urgent, especially in densely populated areas. Urban ecological restoration represents the best approach to undertake damages to restore native ecosystem remnants fulfilling biodiversity but also social goals in dense urban settings such as Mexico City. The feasibility of restoring unique xerophytic scrub vegetation in lava field remnants was evaluated in a portion of a university campus in Mexico City. Here we present an index (Need and Feasibility of Restoration Index, NFRI) for such purpose. The NFRI was designed through multicriteria analysis and considered ecological, economic, and social indicators. Cluster and principal components analysis were carried out to identify different groups of lava field remnants with similar characteristics and to point out critical variables that in turn would support management strategies. The outcomes made evident the necessity of restoring native vegetation for all of the evaluated remnants; however, the group containing the largest ones obtained the highest values for restoration feasibility and NFRI. The recovery of the rest of the remnants is critical to support the ecological restoration of the area as this may provide connectivity with better-preserved ecosystem remnants. When the restoration is unaffordable due to financial constraints, it is highly recommended to direct efforts towards ecological rehabilitation actions. The establishment of native xerophytic gardens is promoted when remnants cannot support a self-sustainable plant community. It is crucial to include the diversity of views and values of the community and the economic and ecological aspects to guarantee the sustainability of the landscape, especially in the urban context. The latter can provide better planning and design processes, ensuring benefits for humans and nature.
Omega-3 Fatty Acids and Inflammation—You Are What You Eat!
Authors: Wierenga Kathryn A. , Pestka James J.
Published: August 2021

Have you ever heard the phrase, “You are what you eat?” Of course, if you eat a donut, you will not actually turn into a donut—but bits and pieces of what we eat do become parts of us! In this article, we will talk about how the fatty acids in our cells can help protect us from various diseases by controlling inflammation. Specifically, we will focus on food components called omega-3 polyunsaturated fatty acids, which are most abundant in seafood. We will talk about how eating foods rich in omega-3s increases the levels of omega-3s in your cell membranes and may protect against several diseases that are associated with uncontrolled inflammation.
Coffee Agroforestry and the Food and Nutrition Security of Small Farmers of South-Western Ethiopia
Authors: Jemal Omarsherif Mohammed , Callo-Concha Daniel , van Noordwijk Meine
Published: August 2021

Agroforestry generally contributes to rural food and nutrition security (FNS). However, specialization on commodity-oriented agroforestry practices or management strategies can weaken local food sourcing when terms of trade fluctuate, as is the case of coffee in Ethiopia. Hence, this study assessed the trade-offs that smallholder farming households in south-western Ethiopia face between growing coffee in agroforestry systems and their food and nutrition security based on home production as well as markets. Data collected from 300 randomly selected households included: (i) attributes of agroforestry practices (AFP) and plants: structure, use type, edibility, marketability, nutritional traits, and (ii) the householders' FNS attributes: food security status, nutritional adequacy, and nutritional status. Data were collected both in food surplus and shortage seasons, during and after coffee harvesting. Within these data, the number of plant species and vegetation stories were significantly correlated with household food access security in both seasons and for all AFP identified, i.e., homegarden, multistorey-coffee-system, and multipurpose-trees-on-farmlands. The number of stories in homegardens and the richness of exotic species in multipurpose-trees-on-farmlands were significantly correlated with the biometric development of children below 5 years old during the shortage season. The richness of “actively-marketed” species in all AFP correlated with the food access security of the household, except in the multistorey-coffee-system, oriented to coffee production. Also, families that cultivate all three AFP showed significantly higher household diversity dietary during the shortage season. We conclude that no single AFP can secure FNS status of the households by itself, but the combination of all three can. Household and individual dietary scores were positively correlated with the AFP diversity-attributes, especially in the shortage season. Thus, the diversity of useful groups of plant species deserves to be promoted for instance by enriching AFP with edible and storable crops needed during the shortage season.
Genome-Wide Scanning Enabled SNP Discovery, Linkage Disequilibrium Patterns and Population Structure in a Panel of Fonio (Digitaria exilis [Kippist] Stapf) Germplasm
Authors: Ibrahim Bio Yerima Abdou R. , Issoufou Kassari Ango , Adje Charlotte A. , Mamadou Aissata , Oselebe Happiness , Gueye Mame Codou , Billot Claire , Achigan-Dako Enoch G.
Published: August 2021

White fonio (Digitaria exilis) is a staple food for millions of people in arid and semi-arid areas of West Africa. Knowledge about nutritional and health benefits, insights into morphological diversity, and the recent development of genomic resources call for a better understanding of the genetic structure of the extant germplasm gathered throughout the region in order to set up a robust breeding program. We assessed the genetic diversity and population structure of 259 fonio individuals collected from six countries from West Africa (Nigeria, Benin, Guinea, Mali, Burkina Faso and Niger) in this study using 688 putative out of 21,324 DArTseq-derived SNP markers. Due to the inbreeding and small population size, the results revealed a substantial level of genetic variability. Furthermore, two clusters were found irrespective of the geographic origins of accessions. Moreover, the high level of linkage disequilibrium (LD) between loci observed resulted from the mating system of the crop, which is often associated with a low recombination rate. These findings fill the gaps about the molecular diversity and genetic structure of the white fonio germplasm in West Africa. This was required for the application of genomic tools that can potentially speed up the genetic gain in fonio millet breeding for complex traits such as yield, and other nutrient contents.
A Landscape Epidemiological Approach for Predicting Chronic Wasting Disease: A Case Study in Virginia, US
Authors: Winter Steven N. , Kirchgessner Megan S. , Frimpong Emmanuel A. , Escobar Luis E.
Published: August 2021

Many infectious diseases in wildlife occur under quantifiable landscape ecological patterns useful in facilitating epidemiological surveillance and management, though little is known about prion diseases. Chronic wasting disease (CWD), a fatal prion disease of the deer family Cervidae, currently affects white-tailed deer (Odocoileus virginianus) populations in the Mid-Atlantic United States (US) and challenges wildlife veterinarians and disease ecologists from its unclear mechanisms and associations within landscapes, particularly in early phases of an outbreak when CWD detections are sparse. We aimed to provide guidance for wildlife disease management by identifying the extent to which CWD-positive cases can be reliably predicted from landscape conditions. Using the CWD outbreak in Virginia, US from 2009 to early 2020 as a case study system, we used diverse algorithms (e.g., principal components analysis, support vector machines, kernel density estimation) and data partitioning methods to quantify remotely sensed landscape conditions associated with CWD cases. We used various model evaluation tools (e.g., AUC ratios, cumulative binomial testing, Jaccard similarity) to assess predictions of disease transmission risk using independent CWD data. We further examined model variation in the context of uncertainty. We provided significant support that vegetation phenology data representing landscape conditions can predict and map CWD transmission risk. Model predictions improved when incorporating inferred home ranges instead of raw hunter-reported coordinates. Different data availability scenarios identified variation among models. By showing that CWD could be predicted and mapped, our project adds to the available tools for understanding the landscape ecology of CWD transmission risk in free-ranging populations and natural conditions. Our modeling framework and use of widely available landscape data foster replicability for other wildlife diseases and study areas.
Weaknesses in Motivation and in Establishing a Meritocratic System: A Portrait of the Portuguese Public Administration
Authors: Nishimura Adriana Z. F. C. , Moreira Ana , Sousa Maria José , Au-Yong-Oliveira Manuel
Published: August 2021

The complexities of Public Administration have gained the growing attention of scholars around the world, mainly due to the impacts of the reforms implemented under the doctrine of New Public Management (which aims to apply concepts and practices of private management in public management) on civil servants. The aim of this study is to find out how Portuguese citizens evaluate the Portuguese Public Administration under the aspects of bureaucracy, organisation of human resources, innovation, skills and attitudes of civil servants, its motivation and recognition; and to verify if there are differences of opinion between respondents working in public sector and respondents from other sectors. This study follows a quali-quantitative approach, and data were collected through an online survey in the period from June to December 2020. The survey was answered by 1119 citizens from all districts of Portugal. The main findings reveal a still high level of bureaucracy in the Portuguese Public Administration; weaknesses in the management of human resources, namely regarding the motivation and recognition of civil servants; and difficulties in the establishment of a meritocratic system of recruitment and performance evaluation of civil servants. Statistically significant evaluation differences (chi-square test and non-parametric Mann–Whitney U tests, involving five hypotheses) were found between the public sector and other sectors, except for the motivation variable.
Sensorless Control for DC–DC Boost Converter via Generalized Parameter Estimation-Based Observer
Authors: Zhang Xiaoyu , Martinez-Lopez Mizraim , He Wei , Shang Yukai , Jiang Chen , Moreno-Valenzuela Javier
Published: August 2021

The full-information state feedback controller is usually used for regulating the output voltage of converters. Sufficient sensors should be adopted to measure all of the states. However, the extensive use of current sensors not only increases the cost of the overall system, but also affects the reliability. In this paper, the sensorless control problem of DC–DC boost converters is addressed to avoid the need for the current sensor. First, a PI passivity-based control (PI-PBC) is proposed to stabilize this converter. The main feature of this design is that the exponential convergence of the system is guaranteed. Afterward, a generalized parameter estimation-based observer (GPEBO) is presented to estimate the inductor current with the finite-time convergence (FTC). By adding this estimate in the above PI-PBC, a sensorless controller is developed. Thanks to this FTC, the exponential convergence of an overall closed-loop system is ensured. Finally, the simulation and experimental results are given to assess the performance of the proposed controller.
Wear Behavior of Uncoated and Coated Tools in Milling Operations of AMPCO (Cu-Be) Alloy
Authors: Sousa Vitor F. C. , Castanheira João , Silva Francisco J. G. , Fecheira José S. , Pinto Gustavo , Baptista Andresa
Published: August 2021

Copper-Beryllium alloys have excellent wear resistance and high mechanical properties, they also possess good electrical and thermal conductivity, making these alloys very popular in a wide variety of industries, such as aerospace, in the fabrication of tools for hazardous environments and to produce injection molds and mold inserts. However, there are some problems in the processing of these alloys, particularly when these are subject to machining processes, causing tools to deteriorate quite rapidly, due to material adhesion to the tool’s surface, caused by the material’s ductile nature. An assessment of tool-wear after machining Cu-Be alloy AMPCOLOY 83 using coated and uncoated tools was performed, offering a comparison of the machining performance and wear behavior of solid-carbide uncoated and DLC/CrN multilayered coated end-mills with the same geometry. Multiple machining tests were conducted, varying the values for feed and cutting length. In the initial tests, cutting force values were registered. The material’s surface roughness was also evaluated and the cutting tools’ edges were subsequently analyzed, identifying the main wear mechanisms and how these developed during machining. The coated tools exhibited a better performance for shorter cutting lengths, producing a lower degree of roughness on the surface on the machined material. The wear registered for these tools was less intense than that of uncoated tools, which suffered more adhesive and abrasive damage. However, it was observed that, for greater cutting lengths, the uncoated tool performed better in terms of surface roughness and sustained wear.
Social and Mental Health Impact of Nuclear Disaster in Survivors: A Narrative Review
Authors: Longmuir Caley , Agyapong Vincent I. O.
Published: August 2021

This narrative review synthesizes the literature on the psychological consequences of the Three Mile Island nuclear accident of 1979, the Chernobyl nuclear disaster of 1986, and the Fukushima nuclear disaster of 2011. A search was conducted on OVID for studies in English from 1966 to 2020. Fifty-nine studies were included. Living through a nuclear disaster is associated with higher levels of PTSD, depression, and anxiety. Decontamination workers, those living in closest proximity to the reactor, and evacuees experience higher rates of mental health problems after a nuclear disaster. Those with greater psychological resilience and social supports experience lower rates of psychological distress. Individual-level interventions, such as mindfulness training, behavioral activation, and cognitive reappraisal training, have shown modest benefits on improving psychological wellbeing. At the population level, many of the measures in place aimed at reducing exposure to radiation actually increase individuals’ anxiety. Technology-based supports have been studied in other types of natural disasters and it may be beneficial to look at mobile-based interventions for future nuclear disasters.
Evaluation of ALARO-0 and REMO Regional Climate Models over Iran Focusing on Building Material Degradation Criteria
Authors: Hedayatnia Hamed , Top Sara , Caluwaerts Steven , Kotova Lola , Steeman Marijke , Van Den Bossche Nathan
Published: August 2021

Understanding how climate change affects material degradation is the first step in heritage conservation. To study such impact, high-resolution climate information is required. However, so far, no regional climate simulations have been evaluated considering building damage criteria over the region of Iran. This paper has a twofold objective: to conduct an overview of climate model performance over Iran by evaluating the output of two regional climate models, ALARO-0 and REMO2015, and to find an optimal approach for model evaluation fitted to studies on building physics. Data of the evaluation run for both models were compared with data of weather stations located in six different climate zones in Iran to assess their performance over the region and gain insight about model uncertainties. Given that the research scope covers the evaluation of climate models to use in studies on building physics, in addition to climate parameters, five degradation risks are analysed. The performance of the two models varies over the studied locations. In general, both models fall within the spread of observations except for wind parameters. Accordingly, indices related to temperature and precipitation are well predicted, in contrast to indices related to wind. The analysis shows that considering the observed biases, selecting an ensemble of representative models based on the evaluation results of climate variables important for hygrothermal simulations would be recommended.
Present Challenges in Catalytic Emission Control for Internal Combustion Engines
Authors: Doronkin Dmitry E. , Casapu Maria
Published: August 2021

Mobility in the modern world relies on heterogeneous catalysis [...]
Chemical Functionalization of Graphene Nanoplatelets with Hydroxyl, Amino, and Carboxylic Terminal Groups
Authors: Peng Cheng , Zhang Xiaoyan
Published: August 2021

As the most studied two-dimensional material, graphene is still attracting a lot of attention from both academia and industry due to its fantastic properties such as lightness, excellent mechanical strength, and high conductivity of heat and electricity. As an important branch of graphene materials, graphene nanoplatelets show numerous applications such as in coating, fillers of polymer composites, energy conversion and storage devices, sensing, etc. Chemical functionalization can introduce different functional groups to graphene nanoplatelets and can potentially endow them with different properties and functions to meet the increasing demand in the fields mentioned above. In this minireview, we present an overview of the research progress of functionalized graphene nanoplatelets bearing hydroxyl, amino, and carboxylic terminal groups, including both covalent and noncovalent approaches. These terminal groups allow subsequent functionalization reactions to attach additional moieties. Relevant characterization techniques, different applications, challenges, and future directions of functionalized graphene nanoplatelets are also critically summarized.
Global Trends in Cosmetics Use-Related Adverse Effects: A Bibliometric Analysis of Literature Published during 1957–2021
Authors: Nayak Manjula , Sreedhar Dharmagadda , Prabhu Smitha S. , Ligade Virendra S.
Published: August 2021

Cosmetic and beauty products, though not essential for physical health, go a long way in providing mental well-being and confidence, and hence are used substantially. Increasing utilization of varying cosmetic products leads to a multitude of adverse effects. There is more awareness about cosmeceutics, cosmetic products and their adverse effects, and studies on the same are currently trending. Bibliometrics has become a prominent and growing field of research in recent years. The aim of this research was to assess bibliometric features and conduct systematic trend analysis on the literature available on cosmetics’ adverse effects. We analyzed all the published documents that included the keywords “cosmetics” and “adverse effects” between 1957 and 2021. We performed a detailed scientometric and bibliometric assessment in this field. A total of 4127 articles were retrieved from the databases provided by Scopus, which most were original articles. The United States ranked first and dominated the literature with 1292 (31.44%) documents followed by South Korea 7.47%. Harvard medical school was the most productive institution (1.16%). The study of the adverse effects of cosmetics should be supported and taken up by the researchers/authors from developing and underdeveloped countries.
Measuring the Effect of Government Response on COVID-19 Pandemic: Empirical Evidence from Japan
Authors: Wang Rui
Published: August 2021

The basic approach of this research is to use an estimated series of effective reproduction number Rt and multiple series of index from Oxford COVID-19 Government Response Tracker (OxCGRT) to measure the effect of Japanese government’s response on COVID-19 epidemic by running a time-varying regression with flexible least squares method. Then, we use estimated series of time-varying coefficients obtained from the previous step as proxy variables for the government response’s effect and run stepwise regressions with policy indicators of OxCGRT to identify which specific policy can mitigate the spreading of the COVID-19 epidemic in Japan. The main finding is that the response of Japanese government on COVID-19 epidemic is basically effective. However, the effect of Japanese government’ policy is gradually weakening. Under our identification scheme, we find that policies of quarantine and movement restrictions are still most effective, but policies of public health system do not show much effectiveness in the regression analysis. Another important empirical finding is that policies of economic support are effective in reducing the spread of COVID-19. Within the framework of empirical strategy proposed in this paper, the conclusion should be explained in the context of the socio-political and health situation in Japan, but the methodology is assumed to be applicable to other countries and regions in the analysis of government performance of response to COVID-19.
Ionic Conductors: Effect of Temperature on Conductivity and Mechanical Properties and Their Interrelations
Authors: Aniya Masaru , Sadakuni Haruhito , Hirano Eita
Published: August 2021

The ionic transport and the mechanical properties in solids are intimately related. However, few studies have been done to elucidate the background of that relation. With the objective to fill this gap and gain further understanding on the fundamental properties of ion conducting materials, we are studying systematically the mechanical properties of different materials. In the present study, after showing briefly our previous results obtained in crystalline materials, results regarding the relation between ionic conduction and mechanical properties in superionic glasses is presented. All these results indicate the intimate relation between the mechanical and ionic conduction. The results also indicate that the Grüneisen parameter and the Anderson–Grüneisen parameter of ionic conductors exhibit large temperature dependence and increase with temperature.
A Study of the Characteristics of Plasma Generated by Infrared Pulse Laser-Induced Fused Silica
Authors: Wang Lixue , Sun Xudong , Geng Congrui , Zhang Zequn , Cai Jixing
Published: August 2021

When high energy infrared laser pulses are incident on fused silica, the surface of the fused silica is damaged and a laser-induced plasma is produced. Based on the theory of fluid mechanics and gas dynamics, a two-dimensional axisymmetric gas dynamic model was established to simulate the plasma generation process of fused silica induced by a millisecond pulse laser. The results show that the temperature of the central region irradiated by the laser is the highest, and the plasma is first produced in this region. When the laser energy density is 1.0 × 104 J/cm2 and the pulse width is 0.2 ms, the maximum expansion velocity of the laser-induced plasma is 17.7 m/s. Under the same experimental conditions, the results of the simulation and experiment are in good agreement. With an increase in pulse width, the plasma expansion rate gradually decreases.
Forecasting Recessions with Financial Variables and Temporal Dependence
Authors: Chu Pyung Kun
Published: August 2021

Extending earlier research on forecasting recessions with financial variables, I examine the importance of additional financial variables and temporal dependence for recession prediction. I show that both additional financial variables, in particular, the Treasury bill spread, default yield spread, stock return volatility, and temporal cubic terms, which account for temporal dependence, independently help to improve not only in-sample, but also out-of-sample recession prediction. I also find that additional financial variables and temporal cubic terms complement each other in enhancing the predictability of recessions, increasing the explanatory power and decreasing prediction error further, compared to their individual performance.
Palynostratigraphy, Palynofacies, T-R Cycles and Paleoenvironments in the Middle Jurassic–Early Cretaceous Ramså Basin, Andøya, Northern Norway
Authors: Smelror Morten
Published: August 2021

Palynostratigraphy and palynofacies analyses are applied to identify transgressive-regressive sequences and changes in paleoenvironment through the Middle Jurassic–Early Cretaceous succession of the Ramså Basin on Andøya. The conglomerate, the succeeding lacustrine-swamp deposits of the Hestberget and Kullgrøfta members (Ramså Formation) and the overlying terrestrial to marginal marine deposits of the lower Bonteigen Member (Ramså Formation), comprise the Bajocian T-R sequence. Bathonian–Oxfordian strata appear to be missing in the studied boreholes, and the second T-R cycle spans the Kimmeridgian to Berriasian open marine deposits of the upper Bonteigen Member and the Dragneset Formation (Breisanden, Taumhølet and Ratjønna members). The overlying Nybrua Formation comprises a condensed marine succession of Valanginian–Early Barremian calcareous sandstone and marl, followed by brownish-red siltstone. The upper T-R sequence (Skarstein Formation) consists of marine transgressive Barremian dark siltstones, silty shales and mudstones, followed by dark mudstone and shale. Marine palynomorphs recovered in these stacked marine slope turbidite sediments are of Late Barremian age, but possibly the youngest T-R cycle also includes Aptian deposits elsewhere in the basin.
YouTube as a Source of Patient Information Regarding Exercises and Compensated Maneuvers for Dysphagia
Authors: Chang Min Cheol , Park Donghwi
Published: August 2021

Objective: Acquiring online health-related information has become increasingly widespread. In this study, we aimed to evaluate the quality of the most-viewed YouTube videos on dysphagia regarding exercises and compensated maneuvers. Method: We searched for the keywords “dysphagia exercise”, “dysphagia rehabilitation”, “dysphagia maneuver”, “dysphagia therapy”, and “dysphagia compensation” on YouTube on 5 February 2021. The educational quality of videos on YouTube was investigated based on the Global Quality Scale (GQS) and categorized into three groups: high-, intermediate-, and low-quality. The modified DISCERN tool was used to evaluate the reliability of the YouTube videos. Video parameters were compared between the groups according to the quality of the videos. Results: Of the 51 videos evaluated, according to the GQS, 54.9% (n = 28) were of high-quality, 35.3% (n = 18) were of intermediate-quality, and 9.8% (n = 5) were of low-quality, respectively. When the video parameters were compared among the groups, there were no significant differences in the number of views, likes, dislikes, or comments per day (p > 0.05). However, there was a significant difference in the DISCERN scores between the groups (p < 0.001). Conclusion: YouTube can be deemed as a predominant source for high-quality videos on dysphagia exercise and compensated maneuvers. However, YouTube should be accepted as a mixed pool, with high-, intermediate-, and low-quality videos. Therefore, healthcare professionals, such as physicians and therapists, should verify the suitability and quality of the video, and suggest it to the patient, to ensure that the patient obtains the appropriate information.
First Detection of the Adventive Egg Parasitoid of Halyomorpha halys (Stål) (Hemiptera: Pentatomidae) Trissolcus mitsukurii (Ashmead) (Hymenoptera: Scelionidae) in France
Authors: Bout Alexandre , Tortorici Francesco , Hamidi Rachid , Warot Sylvie , Tavella Luciana , Thomas Maud
Published: August 2021

We report the first detection of Trissolcus mitsukurii in France. More than 1860 sentinel egg masses of Halyomorpha halys (BMSB) were exposed in the field during the 2018–2020 period, and 12 specimens of T. mitsukurii emerged from one egg mass. Their taxonomic identification was confirmed both by morphological and molecular analysis. Trissolcus mitsukurii, similar to T. japonicus, is an egg parasitoid of BMSB in its area of origin in Asia, and both species are considered to be candidates for a classical biological control strategy against BMSB. Trissolcus mitsukurii was previously recorded in Italy where it is well established and widespread, and this may be the source of the French population. Possible permanent establishment and dispersion of T. mitsukurii in France should be monitored with emphasis on its potential effect on BMSB populations.
Molecular Detection and Phylogenetic Analysis of Tick-Borne Pathogens in Ticks Collected from Horses in the Republic of Korea
Authors: Seo Hyun-Ji , Truong A-Tai , Kim Keun-Ho , Lim Ji-Yeon , Min Subin , Kim Heung-Chul , Yoo Mi-Sun , Yoon Soon-Seek , Klein Terry A. , Cho Yun Sang
Published: August 2021

The horse industry has grown rapidly as a leisure industry in the Republic of Korea (ROK) in parallel with an increased demand for equestrian activities. As a result, there has been an increase in horse breeding and equestrian population and potential exposure to ticks and their associated pathogens. To provide a better understanding of the potential disease risks of veterinary and medical importance, a study was conducted to determine the geographical distribution and diversity of ticks collected from horses and vegetation associated with horse racetracks/ranches throughout the ROK. This included a survey of five associated common pathogens, Anaplasma phagocytophilum, Ehrlichia chaffeensis, Borrelia spp., Babesia caballi, and Theileria equi. A total 9220 ticks were collected from horses and associated pastures. Ticks were identified to species, stage of development, and sex. Two species of ticks, Haemaphysalis longicornis (99.9%) and Ixodes nipponensis (0.1%) were identified. Two of the target pathogens, A. phagocytophilum and Borrelia spp., were detected in 5/1409 tick pools (0.35%) and 4/1409 pools (0.28%) of H. longicornis, respectively, both of which are zoonotic pathogens of medical importance. The results of 16S rRNA phylogenetic analysis of A. phagocytophilum showed a close relationship to strains distributed in China, USA, Germany, Italy, Turkey, and Poland. Borrelia spp. showed a close relationship, based on 16S rRNA gene, to the strains reported from the USA (B. burgdorferi and B. americana) and Japan (B. tanukii and B. garinii). These results provide information about the potential risks of veterinary and medical importance and the development of mitigation strategies for disease prevention.
The Physicochemical, Biopharmaceutical, and In Vitro Efficacy Properties of Freeze-Dried Dexamethasone-Loaded Lipomers
Authors: Pena-Rodríguez Eloy , Mata-Ventosa Aida , Garcia-Vega Laura , Pérez-Torras Sandra , Fernández-Campos Francisco
Published: August 2021

Dexamethasone-loaded polymer hybrid nanoparticles were developed as a potential tool to treat alopecia areata due to their follicular targeting ability. Freeze drying (FD) is a common technique used to improve nanoparticle stability; however, there are few studies focused on its effect on ethyl cellulose lipid-core nanoparticles. Nanoparticles were lyophilized with different cryoprotectants. Sucrose was selected because it allowed for a good resuspension and provided acceptable physicochemical parameters (374.33 nm, +34.7 mV, polydispersion 0.229%, and 98.87% encapsulation efficiency). The nanoparticles obtained were loaded into a pleasant xanthan gum hydrogel, and the rheological, release, and skin permeation profiles of different formulations were studied. The FD formulation significantly modified the particle size, and the drug release and permeation properties were also altered. In addition, analyses of the cytotoxicity and anti-inflammatory efficacy of FD and non-FD particles on human keratinocytes indicated no differences.
Effect of In-Mold Annealing on the Properties of Asymmetric Poly(l-lactide)/Poly(d-lactide) Blends Incorporated with Nanohydroxyapatite
Authors: Boruvka Martin , Cermak Cenek , Behalek Lubos , Brdlik Pavel
Published: August 2021

The proper choice of a material system for bioresorbable synthetic bone graft substitutes imposes strict requirements for mechanical properties, bioactivity, biocompatibility, and osteoconductivity. This study aims to characterize the effect of in-mold annealing on the properties of nanocomposite systems based on asymmetric poly(l-lactide) (PLLA)/Poly(d-lactide) (PDLA) blends at 5 wt.% PDLA loading, which was incorporated with nano-hydroxyapatite (HA) at various concentrations (1, 5, 10, 15 wt.%). Samples were melt-blended and injection molded into “cold” mold (50 °C) and hot mold (100 °C). The results showed that the tensile modulus, crystallinity, and thermal-resistance were enhanced with increasing content of HA and blending with 5 wt.% of PDLA. In-mold annealing further improved the properties mentioned above by achieving a higher degree of crystallinity. In-mold annealed PLLA/5PDLA/15HA samples showed an increase of crystallinity by ~59%, tensile modulus by ~28%, and VST by ~44% when compared to neat hot molded PLLA. On the other hand, the % elongation values at break as well as tensile strength of the PLLA and asymmetric nanocomposites were lowered with increasing HA content and in-mold annealing. Moreover, in-mold annealing of asymmetric blends and related nanocomposites caused the embrittlement of material systems. Impact toughness, when compared to neat cold molded PLLA, was improved by ~44% with in-mold annealing of PLLA/1HA. Furthermore, fracture morphology revealed fine dispersion and distribution of HA at 1 wt.% concentration. On the other hand, HA at a high concentration of 15 wt.% show agglomerates that worked as stress concentrators during impact loading.
Tamed Mobilization. Marian Messages, Pilgrim Masses and Papal Moderateness in Fatima since Paul VI
Authors: Barbato Mariano P.
Published: August 2021

Marian apparitions attract modern masses since the 19th century. The radical message of the apparition asking for penitence and the return of public and politics to God resonated well within major parts of Catholicism. While popes kept promoting Marian pilgrimages in order to secure their public and political standing throughout the 20th and 21st century, they tried to control the masses and to attenuate the messages. Particularly since the Second Vatican Council, the popes tamed mobilization. Instead of stirring up the masses, popes kept modest at Marian apparitions sites. A quantitative analysis of the papal documents issued during papal journeys to Fatima, the most political apparition of the 20th century, shows that a modest religious discourse about God and world had been presented instead of promoting the critical messages of the apparition. Following the methodological ideal of parsimony, the analysis concentrates on the most uttered words during the journeys and compares the four pontificates since Paul VI. Instead of stressing the radical message of Fatima, which is introduced in the discussion of the findings, the pontificates share a modest Catholic discourse.
Prevalence in News Media of Two Competing Hypotheses about COVID-19 Origins
Authors: Rozado David
Published: August 2021

The COVID-19 pandemic has been one of the most disruptive and painful phenomena of the last few decades. As of July 2021, the origins of the SARS-CoV-2 virus that caused the outbreak remain a mystery. This work analyzes the prevalence in news media articles of two popular hypotheses about SARS-CoV-2 virus origins: the natural emergence and the lab-leak hypotheses. Our results show that for most of 2020, the natural emergence hypothesis was favored in news media content while the lab-leak hypothesis was largely absent. However, something changed around May 2021 that caused the prevalence of the lab-leak hypothesis to substantially increase in news media discourse. This shift has not been uniformed across media organizations but instead has manifested itself more acutely in some outlets than others. Our structural break analysis of daily news media usage of terms related to the laboratory escape hypothesis provides hints about potential sources for this sudden shift in the prevalence of the lab-leak hypothesis in prestigious news media.
The Moderating Effect of ‘Generation’ on the Relations between Source Credibility of Social Media Contents, Hotel Brand Image, and Purchase Intention
Authors: Shin Hye-Ryeong , Choi Jeong-Gil
Published: August 2021

This is a timely study that simultaneously considers the issues of source credibility of social media contents and generational differences. The study aims to explore the influence of ‘generation’ on perceived source credibility, and its effect on the relation between source credibility, hotel brand image, and purchase intention in cases where the content providers are general users (UGCs) and hotel marketers (MGCs), respectively. Using an independent samples t-test (278 people sampled), the differences in source credibility between generations were tested and multi-group analysis was conducted to verify the moderating effect of generation. Significant differences appeared in trustworthiness between the generations. Millennials are sharper in observation than the generations born earlier in recognizing the source credibility of social media contents. The moderating effect of generation is noticeable only in the impact of the UGCs’ expertise on hotel brand image, indicating Millennials are affected by the expertise of UGCs more strongly than the earlier generations are. The findings offer insight into better strategizing of social media communication for hotel marketers, utilizing social media and targeting Millennials. A further contribution of the study is that it reveals the relations between variables and effects according to different content providers (UGCs and MGCs).
Comparative Study of Univariate and Multivariate Long Short-Term Memory for Very Short-Term Forecasting of Global Horizontal Irradiance
Authors: Mandal Ashis Kumar , Sen Rikta , Goswami Saptarsi , Chakraborty Basabi
Published: August 2021

Accurate global horizontal irradiance (GHI) forecasting is crucial for efficient management and forecasting of the output power of photovoltaic power plants. However, developing a reliable GHI forecasting model is challenging because GHI varies over time, and its variation is affected by changes in weather patterns. Recently, the long short-term memory (LSTM) deep learning network has become a powerful tool for modeling complex time series problems. This work aims to develop and compare univariate and several multivariate LSTM models that can predict GHI in Guntur, India on a very short-term basis. To build the multivariate time series models, we considered all possible combinations of temperature, humidity, and wind direction variables along with GHI as inputs and developed seven multivariate models, while in the univariate model, we considered only GHI variability. We collected the meteorological data for Guntur from 1 January 2016 to 31 December 2016 and built 12 datasets, each containing variability of GHI, temperature, humidity, and wind direction of a month. We then constructed the models, each of which measures up to 2 h ahead of forecasting of GHI. Finally, to measure the symmetry among the models, we evaluated the performances of the prediction models using root mean square error (RMSE) and mean absolute error (MAE). The results indicate that, compared to the univariate method, each multivariate LSTM performs better in the very short-term GHI prediction task. Moreover, among the multivariate LSTM models, the model that incorporates the temperature variable with GHI as input has outweighed others, achieving average RMSE values 0.74 W/m2–1.5 W/m2.
Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus
Authors: Leneva Irina , Kartashova Nadezhda , Poromov Artem , Gracheva Anastasiia , Korchevaya Ekaterina , Glubokova Ekaterina , Borisova Olga , Shtro Anna , Loginova Svetlana , Shchukina Veronika , Khamitov Ravil , Faizuloev Evgeny
Published: August 2021

An escalating pandemic of the novel SARS-CoV-2 virus is impacting global health, and effective antivirals are needed. Umifenovir (Arbidol) is an indole-derivative molecule, licensed in Russia and China for prophylaxis and treatment of influenza and other respiratory viral infections. It has been shown that umifenovir has broad spectrum activity against different viruses. We evaluated the sensitivity of different coronaviruses, including the novel SARS-CoV-2 virus, to umifenovir using in vitro assays. Using a plaque assay, we revealed an antiviral effect of umifenovir against seasonal HCoV-229E and HCoV-OC43 coronaviruses in Vero E6 cells, with estimated 50% effective concentrations (EC50) of 10.0 ± 0.5 µM and 9.0 ± 0.4 µM, respectively. Umifenovir at 90 µM significantly suppressed plaque formation in CMK-AH-1 cells infected with SARS-CoV. Umifenovir also inhibited the replication of SARS-CoV-2 virus, with EC50 values ranging from 15.37 ± 3.6 to 28.0 ± 1.0 µM. In addition, 21–36 µM of umifenovir significantly suppressed SARS-CoV-2 virus titers (≥2 log TCID50/mL) in the first 24 h after infection. Repurposing of antiviral drugs is very helpful in fighting COVID-19. A safe, pan-antiviral drug such as umifenovir could be extremely beneficial in combating the early stages of a viral pandemic.