bluuebunny/crossref_metadata_2025 huggingface dataset:
Инновации в лечении эндометриоза: от традиционных методов к перспективным стратегиям
Authors: Голубева А.О. , Дёмина Е.О. , Рудык А.В. , Хуранова Д.А. , Моргоева Т.З.
Published: December 2024

Эндометриоз – это распространенное хроническое заболевание, затрагивающее значительное число женщин репродуктивного возраста и оказывающее серьезное влияние на качество их жизни, фертильность, а также на эмоциональное и социальное благополучие. Несмотря на многолетние исследования, до сих пор не существует унифицированного подхода к лечению эндометриоза, что подчеркивает необходимость поиска и оценки эффективности новых терапевтических методов. Статья представляет собой анализ современных подходов и инноваций в лечении эндометриоза – заболевания, затрагивающего значительную часть женского населения репродуктивного возраста. Авторы рассматривают перспективные направления исследований, включая таргетную терапию, иммунотерапию, применение биотехнологий и генной инженерии, подчеркивая важность адаптации медицинских инноваций с учетом индивидуальных особенностей пациенток. Отдельное внимание уделяется необходимости комплексного подхода, включающего психологическую поддержку и коррекцию образа жизни. Статья подчеркивает важность дальнейших исследований для разработки эффективных и безопасных методов лечения эндометриоза, учитывающих индивидуальные особенности каждой пациентки.

Endometriosis is a prevalent chronic disease affecting a significant number of women of reproductive age, seriously impacting their quality of life, fertility, and emotional and social wellbeing. Despite years of research, there still lacks a unified approach to the treatment of endometriosis, highlighting the need for the exploration and evaluation of new therapeutic methods’ effectiveness. This article presents an analysis of current approaches and innovations in treating endometriosis, a condition affecting a considerable portion of the female population at reproductive age. The authors examine promising research directions, including targeted therapy, immunotherapy, the application of biotechnologies, and genetic engineering, emphasizing the importance of adapting medical innovations considering the individual characteristics of patients. Special attention is given to the necessity of a comprehensive approach that includes psychological support and lifestyle adjustments. The article underscores the importance of further research to develop effective and safe treatment methods for endometriosis, considering the individual peculiarities of each patient.
نوادرُ مخطوطاتِ المصاحفِ المغربيةِ العتيقةِ في خَزائنِ المكتباتِ التُّركيّة دراسةٌ تاريخيةٌ وصفيةٌ تحليليةٌ
Authors: Salihoğlu Alaaddin
Published: December 2024

تُعَدُّ المصاحف المخطوطة القديمة مصادرَ أوليةً تكشف عن مسار تطوّر علوم القرآن وتقاليد كتابة المصاحف، وخصائصها الجغرافية والزمنية. وانطلاقاً من هذا المبدأ فإنه يتعيّن دراسة المخطوطات القرآنية ليس فقط من حيث سماتها الشكلية والفنية فحسب، بل أيضًا من منظور علوم القرآن. تهدف هذه الدراسة إلى تسليط الضوء على بعض المصاحف المغربية المخطوطة، التي تُعَدُّ جزءًا جوهريًا من التراث الثقافي الإسلامي. حيث يتمحور البحث حول ثلاث مخطوطات قرآنية مغربية محفوظة في مكتبات مغنيسا وبايزيد والسليمانية. وتكمن أصالة الدراسة في دراسة هذه المصاحف وفق منهجية تاريخية ووصفية وتحليلية، ونشرها للمرة الأولى. ولتحقيق هذه الغاية، تناولت الدراسة أولاً التطور التاريخي لكتابة المصاحف في المغرب والأندلس، بهدف تسليط الضوء على أصل مفهوم الخط الكوفي-الحجازي وعلاقته بالخط المغربي. ثم قامت بتوصيف الخصائص الفنية والشكلية للمخطوطات القرآنية المختارة للدراسة، أعقبه تحليل علميّ لمحتواها من حيث علوم القراءات ورسم المصحف وضبطه وعدّ الآي. وبذلك، تم تحديد العلاقة بين هذه المصاحف ومثيلاتها في المشرق الإسلامي، وإلقاء الضوء على تاريخ كتابة المصاحف في الحقبة الزمنية الخاصة بالنماذج المدروسة.
الحماية المدنية للذكاء الاصطناعي التوليدي
Authors: حازم أكرم صلال  , فارس كامل حسن
Published: December 2024

إنَّ التقدم الهائل في مجال الذكاء الاصطناعي التوليدي تجلَّى عنه تساؤلات حول كيفية حماية المحتوى الذي تنتجه هذه الأنظمة قانونيًا، ومن يمتلك حقوقه، إذ تتباين الآراء حول إمكانية منح الذكاء الاصطناعي شخصية قانونية، وهو مفهوم يعني الاعتراف به ككيان يكتسب بالحقوق ويُثقل بالالتزامات، غير أن هذا الطرح يواجه أزمات قانونية كُثر، أهمها غياب الإدراك والتمييز لدى الأنظمة الذكية، وهما من الشروط الأساسية لأي مسؤولية قانونية-غالباً- لذلك، يظل هذا الخيار موضوع نقاش نظري أكثر منه عملي في الوقت الراهن، إلَّا أنَّ من يقول بعدم حصوله مستقبلاً فإنَّما هو موغلٌ في مجانبة الصواب!
ولما كانت قوانين الملكية الفكرية تُعتبر إطارًا واقعيًا لحماية محتوى الذكاء الاصطناعي، حيث تُنسب الحقوق لمالك أو مصمم البرنامج، فأن هذه القوانين تواجه تحديات مثل تحديد المسؤولية عن الانتهاكات (المبرمج، الشركة المالكة، أو المُلقن)، وأصالة المحتوى الناتج، وما إذا كان يُعتبر عملاً إبداعيًا يستحق الحماية، فالحل يكمن في تحديث القوانين لتواكب تطور الذكاء الاصطناعي، مما يضمن التوازن بين الابتكار وحماية الحقوق.
“Bajar el cuadro”: la historia de una fotografía performativa
Authors: Gamarnik Cora
Published: December 2024

El 24 de marzo de 2004 el presidente Néstor Kirchner ordenó descolgar los cuadros de los dictadores Jorge Rafael Videla y Reynaldo Bignone, antiguos directores del Colegio Militar y presidentes de facto durante la última dictadura cívico militar (1976 a 1983), del Patio de Honor del Colegio Militar. Bajar los cuadros fue un acto didáctico y al mismo tiempo aleccionador, una acción que reducía el poder original de las imágenes para mostrar un cambio de época, la necesidad de refundar las fuerzas armadas bajo las premisas de los derechos humanos. En términos de Bredekamp (2017), fue un acto icónico y, en este caso en particular, un acto icónico sustitutivo. Se descolgó una imagen para producir otra. Bajar los cuadros fue también un acto iconoclasta. Se quitaron las imágenes del lugar de honor en el que se encontraban como una forma de “destrucción creativa” (Mitchell, 2017) para generar imágenes nuevas. La acción que operó en un nivel simbólico quedó sintetizada sobre todo en tres fotografías y en una transmisión en directo por televisión que luego fue reproducida en documentales, noticieros y programas de TV. La potencia política de esta fotografía oscila entre un doble poder. La posibilidad de condensar una historia y al mismo tiempo impulsar otra. En ese sentido, se transformó en una imagen performativa. El artículo describe los pormenores alrededor de la acción de bajar los cuadros y los acontecimientos posteriores. Analiza las fotografías resultantes, sus condiciones de posibilidad, las derivas y las disputas que se dieron a partir de ese acto. La imagen se incorporó con fuerza propia en el debate político, ayudó a construir una identidad militante a partir de ese símbolo y continúa incidiendo en la vida política argentina actual y en las luchas por la memoria.
La fábrica de imágenes de la ESMA. Tomar fotografías como trabajo forzado en un centro clandestino de detención
Authors: Feld Claudia
Published: December 2024

Este artículo indaga en la tarea de tomar fotografías que debieron realizar, como parte de sus trabajos forzados, algunos secuestrados en el centro clandestino de detención ESMA, entre 1977 y 1983. El artículo reconstruye, primero, el funcionamiento del laboratorio fotográfico explicando su rol en el sistema de represión y poder instaurado allí, y definiendo cuatro etapas y “equipos” de prisioneros-fotógrafos. Luego, se analizan dos corpus de fotos tomadas por ellos: 1) fotos de represores destinadas a falsificar documentos de identidad; 2) fotografías realizadas a espaldas de los victimarios, como modo de transgresión. En este marco, se examinan distintos sistemas de contigüidades espaciales entre el acto fotográfico y la violencia, postulando la existencia de diversos espacios “en suspenso”, interiores al centro clandestino pero exteriores a sus lógicas. El artículo problematiza, así, la relación entre fotografía y cautiverio en el marco de la última dictadura en Argentina, entendiendo a la fotografía como una práctica particular desarrollada en el marco de sujeciones y resistencias.
Vistazo al pasado. Fotograbado y espectáculo en la historiografía visual de Caras y Caretas (1898-1910)
Authors: Szir Sandra
Published: December 2024

Este trabajo explora la utilización de la imagen fotográfica en los primeros años del semanario popular ilustrado Caras y Caretas, publicado entre 1898 y 1939, en relación con contenidos del pasado histórico nacional. Se indaga en los modos cómo los artículos tratan discursiva y visualmente a las figuras individuales como San Martín o Rosas y sus imágenes, o acontecimientos como la conquista del desierto o la Semana de Mayo, a la vez que otro tipo de historias culturales, de costumbres como los antiguos carnavales. Recorre así las diversas estrategias y modalidades en las prácticas visuales comunicativas de Caras y Caretas que transitan de la utilización de la imagen en un sentido documental cientificista a la recreación ficcional de acontecimientos históricos. Se muestra entonces el cruce cultural entre la apelación al pasado y la identidad nacional, la tecnología material moderna del fotograbado y la cultura visual masiva.
Pensar las imágenes: los lazos entre fotografía, historia y política
Authors: Gamarnik Cora
Published: December 2024

.
El diseño mutante
Authors: Camusso Mariangeles , Marchetti Viviana
Published: December 2024

La transformación constante que sufren los corpus de los diarios digitales analizados: La Nación,Clarín, Página/12 nos lleva a reflexionar sobre las modificaciones de la lógica proyectual de la tarea dediseño. Los diarios digitales resignifican la utilización de cualisignos como la imagen, el color, la tipografía,la retícula y le quitan al diseñador cierta capacidad de “cerrar” su producto en post de una instancia departicipación del lector-navegador. Es el diseño de una apuesta posible que será actualizada de maneradiversa en cada instancia de uso.Nuestra investigación se ocupa de describir y analizar la amplia gama de estéticas y poéticas utilizadas paraconstruir la narrativa del momento. Desde el punto de vista metodológico, al abordar las dificultades para definir un corpus “inestable” temporal y espacialmente nos enfrentamos a la necesidad de pensar y consensuar nuevas herramientas semiótico analíticas
Sağlık Harcamaları ve Ekonomik Büyüme İlişkisi: BRIC ve MIST Ülkeleri İçin Bir Değerlendirme
Authors: Pehlivanoğlu Ferhat , Acar Merve
Published: December 2024

Bireyin merkezde yer aldığı beşerî sermaye kavramı, toplumsal gelişimde büyük rol üstlenen; eğitim ve sağlık gibi kavramlarla da olan ilişkisiyle dikkat çekmektedir. Sürdürülebilir ekonomik büyümenin sağlanabilmesi ülkedeki bireylerin fiziksel ve ruhsal açıdan sağlıklı bireyler olması ile mümkün olmaktadır. Dolayısıyla ülkelerin gerçekleştirecekleri sağlık yatırımları bireylerin verimliliklerinin artmasına ve ekonomik büyümeye katkı sağlayacaktır. Bu çalışma, BRIC ve MIST ülkelerinde sağlık harcamaları ile ekonomik büyüme arasındaki nedensellik ilişkisini incelemektedir. 2000-2019 dönemini kapsayan veriler panel veri yöntemi ile analiz edilmiş ve Driscoll-Kraay (1998) tahmincisi ile model oluşturulmuştur. Dumitreschu-Hurlin (2012) nedensellik testi kullanılarak sağlık harcamaları ile ekonomik büyüme arasında karşılıklı bir nedensellik ilişkisinin olduğu tespit edilmiştir. Çalışma, bireylerin sağlık harcamaları ve yatırımlarıyla ekonomik büyüme arasındaki önemli bağı vurgulamakta ve bu ilişkinin sürdürülebilir ekonomik büyüme için kritik olduğunu ortaya koymaktadır. Araştırmanın sonuçları, gelişmekte olan ülkelerin sağlık politikalarının ekonomik büyümeye olan katkısını önemini de ortaya çıkarmıştır.
Ortak Zihinsel Modellerin Sanal Takımlara Katkıları: Performans ve İşbirliğini Artıran Bir Dinamik
Authors: Of Mustafa , Gökkaya Öznur
Published: December 2024

Sanal takımlarda ortak zihinsel modeller, iletişim, uyum ve iş birliği süreçlerinin geliştirilmesinde önemli bir yapı taşı olarak öne çıkmaktadır. Özellikle fiziksel etkileşimin sınırlı olduğu sanal ortamlar için geliştirilen bu modeller, takım üyelerinin ortak bir anlayış geliştirmesine imkân tanır ve takım performansını artırır. Bu çalışma, sanal takımların performansına ve iş birliğine yönelik olarak ortak zihinsel modellerin katkılarını incelemektedir. Sanal çalışma ortamlarının karmaşıklığı ve fiziksel mesafelerin getirdiği iletişim zorlukları, takım üyeleri arasında ortak bir anlayış geliştirilmesini zorlaştırmaktadır. Bu bağlamda, ortak zihinsel modellerin, takım üyeleri arasında daha etkili iletişim ve koordinasyon sağladığı, karar verme süreçlerini hızlandırdığı ve takım verimliliğini artırdığı görülmektedir. Çalışmada, mevcut literatür ışığında, ortak zihinsel modellerin sanal takımlarda nasıl geliştirildiği ve performans üzerindeki olumlu etkileri ele alınmaktadır. Ayrıca, sanal takımlarda liderlik ve iş birliği süreçleri ile ortak zihinsel modeller arasındaki ilişki de değerlendirilmiştir. Son olarak, bu modellerin sanal ortamlarda nasıl daha verimli bir şekilde kullanılabileceği ve gelecekteki çalışma alanları tartışılmıştır.
Second-hand clothing classification algorithm based on feature
fusion and attention
Authors: CHENG TING , ZHANG YUN , LI WEIBO , ZHANG JUNJIE
Published: December 2024

This study suggests a second-hand clothing categorization method based on enhanced residual networks to enhance
the effect of second-hand clothing retrieval and encourage clothing transactions on second-hand platforms. This study
first gathers image data on used garments. Web crawlers are utilized to gather internet photos of second-hand clothes
to train the network model, while camera equipment is used to take pictures of second-hand clothing. The resulting
images are then used to assess the network model’s categorization accuracy. The next step is to construct a
classification model based on ResNet50, add an attention mechanism, and carry out feature extraction in stages. Finally,
the developed classification model’s performance is assessed and contrasted with other approaches. The experimental
findings demonstrate that this strategy outperforms previous methods in terms of classification accuracy on the self-built
dataset and DeepFashion dataset, reaching 79.69% and 82.22%, respectively. Additionally, the sorting and recycling of
used clothing is greatly assisted by this method.
Effect of walking speed on the evaporation coefficient of defence workwear
Authors: ALFALEH AYMAN
Published: December 2024

The ripstop fabrics are highly appreciated in the military and defence workwear. One of the qualities requirements in
defence clothing is quick evaporation. The effect of the wearer’s walking speed on textile fabric evaporation during
capillary rise was investigated in this study. To achieve this, two steps were taken: modelling the capillary considering
evaporation and estimating the coefficient of evaporation using a program designed for image analysis. The walking
speed was simulated by varying the air velocity from 0 m/s (non-walking) to 1 m/s (walking) and 2 m/s (running). Results
conclusively demonstrated that the evaporation coefficient is directly relational to the water vapour in the surrounding
air layer and is highly dependent on the aeration rate. Furthermore, liquid equilibrium front level and capillary diffusion
were found to be inversely proportional to the walking speed. The walking speeds affected the indirect water amount on
the fabrics and it was more difficult to evaporate liquid from the 100% cotton compared to 65% polyester/35% cotton/
A highlight sharp estimates for multilinear pseudodifferential operators
Authors: SuhaSoliman SuhaSoliman , ShawgyHussein ShawgyHussein
Published: December 2024

M. Cao, Q.Xue and K.Yabuta [52] investigate the boundedness of the multilinear pseudodifferential operator
𝑇𝜎𝑘
.They establish the local exponential decay estimates for 𝑇𝜎𝑘
. In terms of the corresponding commutators
𝑇𝜎𝑘,𝛴𝑏,they obtain the local subexponential decay estimates. They also derive the weighted mixed weak type
inequality for 𝑇𝜎𝑘
, which parallels Sawyer’s conjecture for Calderon-Zygmund operators and covers the
endpoint weighted inequalities. In addition they present the sharp weighted estimates for 𝑇𝜎𝑘
and 𝑇𝜎𝑘,𝛴𝑏.We
follow [52] to do a slight application on the verified valid rare results.
Role of Social Media on Stock Market Participation: A Study of Self-Employed Women in Kerala
Authors: Salim K C Muhammed , Dr. C.V. Shaji Dr. C.V. Shaji
Published: December 2024

The availability of all financial and non-financial information almost free of cost globally through social media and various internet sources has enhanced stock market participation in every corner of the globe.Kerala is a state in India with a high literacy rate and a remarkable portion of the population are self-employed, especially women. A recent survey reveals that 68% of women aged 30 -50 in Kerala are very active on social media. They try to get tips from social media that are useful for the selection of the best investment options.This research article examines how self-employed women in Kerala utilise social media platforms to educate themselves, gain financial literacy,andearn profit from stock market investments. Through a blended method approach mixingonline surveys and direct interviews, the researcher investigates the opportunities and challenges of social media. The findings of the study reveal that financial information passed through social media platforms acts as a double-edged sword, helping to create a well-diversified portfolio while also misleading via false information.
A Brief Review on Herbal Curcuma Longa
Authors: Sheshrao Kondke Mr.Rutik , Chandile Miss Ashwini , Khule Swapnil Baban , Khillare Vaibhav Shrirang , Kurund Rohit Ramdas , Dr.DK.Vir Dr.DK.Vir
Published: December 2024

Curcuma, commonly known as turmeric, is a
flowering plant of the Zingiberaceae family, with
its rhizomes (underground stems) being the primary
source of its medicinal properties. Curcuma longa,
the most widely studied species, contains bioactive
compounds such as curcumin, which has gained
attention for its broad range of therapeutic effects.
These include anti-inflammatory, antioxidant,
antimicrobial, and anticancer properties. Curcuma
has been traditionally used in various cultures for
its ability to promote digestion, alleviate pain,
enhance skin health, and improve cognitive
function. Recent scientific studies have
substantiated many of these traditional uses,
showing that curcumin can modulate key signaling
pathways involved in chronic diseases, including
cancer, diabetes, cardiovascular diseases, and
neurodegenerative conditions. Despite its
therapeutic potential, the bioavailability of
curcumin is low, which has led to the development
of novel formulations aimed at enhancing its
absorption and efficacy. This abstract explores the
pharmacological properties of Curcuma, its role in
traditional and modern medicine, and ongoing
efforts to optimize its clinical applications.
Additionally, the safety profile and potential side
effects of Curcuma-based treatments are discussed,
providing a comprehensive overview of this widely
used herbal remedy and its future prospects in
integrative medicine. Curcuma, commonly known
as turmeric, is a perennial herb in the Zingiberaceae
family, renowned for its medicinal properties.
An overview on a Computer-Aided Drug Designby Pharmacophore modelling and Virtual screening approach.
Authors: Bapusaheb Jare Krushna , Gore Miss.Aaditee , T.Salve Dr.Megha
Published: December 2024

The drug discovery process is a
rocky path that is full of challenges, with the result
that very few candidates progress from hit
compound to a commercially available product,
often due to factors, such as poor binding affinity,
off-target effects, or physicochemical properties,
such as solubility or stability. This process is
further complicated by high research and
development costs and time requirements. It is thus
important to optimize every step of the process in
order to maximize the chances of success. As a
result of the recent advancements in computer
power and technology, computer-aided drug design
(CADD) has become an integral part of modern
drug discovery to guide and accelerate the process.
Computer-aided drug discovery techniques reduce
the time and the costs needed to develop novel
drugs. Their relevance becomes more and more
evident with the needs due to health emergencies as
well as to the diffusion of personalized medicine.
Pharmacophore approaches represent one of the
most interesting tools developed, by defining the
molecular functional features needed for the
binding of a molecule to a given receptor, and then
directing the virtual screening of large collections
of compounds for the selection of optimal
candidates. Computational tools to create the
pharmacophore model and to perform virtual
screening are available and generated successful
studies. This article describes the procedure of
pharmacophore modelling followed by virtual
screening, the most used software, possible
limitations of the approach, and some applications
reported in the literature.
SyzygiumCumini [L]: A Review of its Antidiabetic activity
Authors: Raju *Gagare Aditi , Vinayak Nimse Gauri , Changedev, Landge Kalyani , Bhausaheb .Kolse Pooja
Published: December 2024

Syzygiumcumini (S. cumini) (L.) Skeels
(jambolan) is one of the broadly used medicinal
plant life in the remedy of numerous diseases
especially diabetes. the existing review has been
primed to describe the present facts at the statistics
on botany, phytochemical elements, conventional
makes use of and pharmacological movements of
S. cumini (L.) Skeels (jambolan). electronic
database search was carried out with the quest
phrases of Eugenia jambolana, S. cumini,
jambolan, not unusual plum and java plum. The
plant has been viewed as an antidiabetic plant since
it have become commercially available several
decades ago. at some stage in last 4 many years,
numerous folk medicine and scientific reports at
the antidiabetic results of this plant have been
mentioned inside the literature. The plant is rich in
compounds containing anthocyanins, glucoside,
ellagic acid, isoquercetin, kaemferol and myrecetin.
The seeds are claimed to contain alkaloid,
jambosine, and glycoside jambolin or antimellin,
which halts the diastatic conversion of starch into
sugar. The good sized variety of literatures found
inside the database discovered that the extracts of
various components of jambolan showed enormous
pharmacological actions. We suggest that there is a
need for similarly research to isolate lively
principles which confer the pharmacological
movement. for this reason identification of such
energetic compounds is useful for generating safer
pills in the treatment of various illnesses inclusive
of diabetes.
Non-Pharmacological Management of Hypertension-A Systematic Approach
Authors: Shalini V Shalini V , Abhinayani G Abhinayani G , Mahendar Ram G Mahendar Ram G , Keerthy V Keerthy V , Hareesh M Hareesh M
Published: December 2024

Introduction:Hypertensionisamajorpublichealthco
ncernworldwide,contributingsignificantly to
cardiovascular morbidity and mortality.
Understanding its prevalence
andassociatedriskfactorsiscrucialforeffectivepreven
tionand managementstrategies.
Methods:ThiscrosssectionalstudywasconductedamongadultpatientsofT
elanganabetween November and April. A
structured questionnaire was used to collect
demographicinformation, contributing factors such
as physical activity, alcohol consumption,
nutrition,nicotine and current use antihypertensive
medication. Hypertension was defined as
systolicbloodpressure(SBP)≥140
mmHgand/ordiastolic bloodpressure(DBP)
≥90mmHg.
Results: A total of 482 adult patients participated
in the study of Prevalence of
hypertension.Themeanageofhypertensivepatientswa
s45years,withahigherprevalenceobservedamongmal
es(53.7%)comparedtofemales(46.3%).Multivariatea
nalysisrevealedsignificantassociationsbetweenhype
rtensionandage,gender,familyhistoryofhypertension
,andphysicalinactivity.
Conclusion: This cross-sectional study highlights a
high prevalence of hypertension amongadult
patients in Telangana. Age, gender, family history,
obesity, and physical inactivity
wereidentifiedassignificantriskfactorsforhypertensio
n.Thesefindingsunderscoretheimportanceof
targeted interventions aimed at lifestyle
modifications and early detection to mitigate
theburdenof hypertension and
itsassociatedcomplications.
Stability indicating HPLC method development and validation for quantification of salicylic acid impurity in acetaminophen aspirin caffeine oral solid dosage forms
Authors: Hareesh Divadari Hareesh Divadari , Teja Kamireddy Teja Kamireddy , Rama Krishna Mynen Rama Krishna Mynen , Vijaykumar Chollety Vijaykumar Chollety , Pranitha Sambu Pranitha Sambu , SrinivasuluKasa SrinivasuluKasa , Ashok Morsu Ashok Morsu , Prasanna Kumar Lankalapalli Prasanna Kumar Lankalapalli
Published: December 2024

The present study discusses the
development of simple isocratic reversed-phase
HPLC method was developed and validated for the
quantification of Salicylic acid, itwas amajor
degradant impurity of Aspirin, in the
Acetaminophen Aspirin Caffeine Tablet dosage
formulations. The analytes were separated on a
C18 Zodiac column (100mm x 4.60 mm i.d., 5 μm
particle size). A mobile phase, water, MeOH,
Glacial acetic acid in the ratio of (690:280:30)
(v/v/v) were used. The column temperature 45℃
and flow rate 2.0ml/mint.The UV detection was
made at 302 nm for Salicylic Acid. The HPLC
method was obtained highly specific with linearity
concentration ranging between 0.373-
112.079μg/mL of salicylic Acid, and the
correlation coefficient was found to be >0.999 The
method showed high accuracy more than 97%. The
limit of detection(LOD) for Salicylic acid
was0.41μg/ml, respectively. The limit of
quantification (LOQ) for salicylic acid was
1.25μg/ml,respectively. Validation acceptance
criteria were met in all cases. The developed
method was validated as per international ICH
guidelines with respect to specificity, linearity,
precision, accuracy and robustness. In stress studies
the Acetaminophen Aspirin and caffeine tablets
were found to be sensitive inAcid, Base stress
conditions and Oxidation stress condition.
Theproposed method was established to be precise
and stability indicating as no interfering peaks of
degrades and excipients were observed. The
proposed method is suitable for purpose in quality
control laboratories forquantitative analysis of
salicylic acid in Acetaminophen Aspirin and
caffeine tablet, as it is simple and rapid with
tremendous precision and accuracy.
Expression and Evaluation of Polyherbal Tablet
Authors: Gawande Siddhant , Ghadge Aditya , Sakore Asmita
Published: December 2024

Herbal tablet expression dates back to ancient
civilisations, where traditional knowledge and
natural resources were employed to create effective
remedies. They used a combination of powdered
plant substance, natural binders and manual
compression techniques to formulate the tablets.
Historical records from regions similar as India,
China, and the Mediterranean reveal different
approaches to herbal tablet preparation. Herbal
tablet surfaced as a safe, effective, and accessible
substitute to synthetic medicine. This study focuses
on the expression and evaluation of a herbal tablet
prepared using Liquorice (Glycyrrhiza glabra),
Ashwagandha (Withania somnifera), Amla
(Phyllanthus emblica), and Tulsi (Phyllanthuus
emblica) through wet granulation method. The
herbs were named for their synergistic properties,
including anti-inflammatory, anti-oxidant, and
immune-boosting effects. The wet granulation
method was employed to ensure uniformity,
improve compressibility and achieve solid tablet
structure. The set tablets were subordinated to
standard physicochemical evaluation parameters
such as hardness, friability, weight variation, and
disintegration. All parameters complied with
pharmacopeial norms, indicating the quality and
stability of the expression. The result demonstrated
that the herbal tablet expression is effective in
delivering the combined remedial benefits of the
selected herbs. This study highlights the future of
integrating traditional herbal knowledge with
ultramodern pharmaceutical methods to produce
standardised, efficacious, and patient friendly
herbal tablets. Advanced exploration involving
clinical evaluation will strengthen the utility of this
expression in the remedial operations.
Review on Different Preparation Methods Used for Dvelopment of Curcumin Nanoparticles
Authors: A.C. Potraje A.C. Potraje , B.Y. Zade B.Y. Zade , Asst.Prof G . N. Gujatwar, Asst.Prof G . N. Gujatwar, , Dr. N. O . Chachda Dr. N. O . Chachda
Published: December 2024

A design and development of herbal (i.e.
Curcumin) nanoparticles it has become a extremes
research in the Nano formulation field. Curcumin,
an orange crystalline powder which derived from
the herbs of curcuma longa linn (Zingiberaceae), it
is natural hydrophobic polyphenol compound
mainly applied in Chinese medicine and some of
the food industries, which supply different
biological and pharmacological activity including
antioxidant, anti-inflammatory, anti-microbial,
anti-neoplastic, anti-diabetic and chemo preventive
properties. Curcumin (diferuloylmethane) is one of
the potent, nontoxic, and major bioactive
components pre sent in turmeric. The major
drawbacks of curcumin are low absorption and
poor bioavailability. The present review highlights
on the methods for the fabrication of curcumin
nanoparticles and their applications in treatment of
cancer and wound infections. Curcumin nano
particles possess remarkable antibacterial, antiviral,
and antiprotozoan activity. hence, curcumin
nanoparticle loaded nano-gel, microemulsion, and
nano-cream can be used for drug delivery.
Curcumin shows therapeutic efficacy against many
human illness and diseases but clinical application
of this compound is limited due to its poor
bioavailability, poor water solubility, fast
metabolism, susceptibility to degradation in the
alkaline medium. One of the most important
technique/ method to improve the poor
biopharmaceutical properties of the curcumin is to
enhance aqueous solubility, bioavailability by
using nanotechnology and nanoparticles, having a
small size in nanometer range. In this review, there
are various methods used for preparation of
curcumin nanoparticles are briefly discussed
Therapeutic application of monoclonal antibodies: A review
Authors: Sana Nusrat Praween Sana Nusrat Praween , Tanya Sharma Tanya Sharma , Dr. Kaushal Kishore Chandrul Dr. Kaushal Kishore Chandrul
Published: December 2024

Overview. An essential family of proteins called
antibodies is created when the body mounts an
immunological defense against a foreign substance.
Antibodies fall into five main classes: IgM, IgG,
IgA, IgD, and IgE. Immunoglobulins vary in their
structure and immunological activity. Multiple
disulphide linkages bind the two light and two
heavy chains that make up an antibody. On light
and heavy chains, there are variable portions called
the fragment antigen-binding (Fab) area and a
constant region called the fragment crystallizable
(Fc) region. As a class, antibodies are broadspectrum antimicrobial drugs that can combat any
type of disease.
Individual antibodies, however, are typically
pathogen-specific. Antibody engineering methods
including hybridoma, phage display, and transgenic
technologies can be used to create monoclonal
antibodies, which only identify one epitope of the
cognate antigen. Antibody fragments like Fab,
scFv, and diabodies are produced when the
complete constant region or a piece of the entire Fc
area is removed. Antibody fragments are more
suitable for therapy than the entire antibody
because of their superior tissue or tumor
penetration properties. Aim. By altering their
structural or functional characteristics, antibodies
can now be used for a variety of therapeutic
purposes.
A Comprehensive Review of Speech-ToText Technologies: Incorporating Translation, Summarization, And Beyond
Authors: Alen Thomas Alen Thomas , Rosu J Edanad Rosu J Edanad , Sourav J Raju Sourav J Raju , Suchitra NT Suchitra NT , Syeatha Merlin Thampy Syeatha Merlin Thampy
Published: December 2024

—Speech-to-text technologies have
transformed the way humans interact with
computers by allowing spoken lan- guage to be
transcribed effortlessly into written form. In
addition to transcribing, incorporating translation
and summarization features boosts the accessibility
and usefulness of speech-to-text systems in various
languages and fields. This paper investigates the
changing STT technology landscape, focusing on
its role in live communication, processing
multiple languages, and creat- ing content. The
paper emphasizes the possibility of advanced
applications in education, business, and
accessibility services by tackling issues such as
language diversity, and context awareness.
Next-Generation Air Conditioning: Leveraging Machine Learning For Advanced System Modeling and Optimization
Authors: Prince N Nwankwo Prince N Nwankwo , A.N Isizoh A.N Isizoh
Published: December 2024

The introduction of next-generation HVAC
(Heating, Ventilation, and Air Conditioning)
systems has spurred a revolution in HVAC
technology, especially with regard to the
incorporation of machine learning algorithms for
improved system optimization. The ideas of
innovation (next generation), technology (machine
learning), and practical application (system
modeling and optimization) are all skillfully
combined in this study. It investigates how to use
cutting-edge machine learning approaches to
enhance the operational effectiveness, energy
efficiency, and adaptability of air conditioning
systems.Using time series analysis and machine
learning approaches, the study focuses on
developing an advanced model and algorithm to
estimate the energy usage of air conditioners.The
goal is to develop a system that can forecast energy
consumption in response to time and environment
dependent factors like temperature, humidity, and
daytime. Precise estimation of energy usage can
enhance the effectiveness of air conditioning
systems, minimize energy wastage, and boost
financial viability, particularly in residential and
commercial structures. The outcomes of this study
underline the feasibility of machine learning as a
vital instrument in defining the future of HVAC
technology and the broader sustainability of
building management systems. These results offer a
way forward for creating intelligent, cutting-edge
air conditioning systems that tackle environmental
and financial issues.
Machine Learning for Predictive Maintenance in Industrial Iot: A Comparative Study of Algorithms and Applications
Authors: Akpan Itoro Udofot Akpan Itoro Udofot , Omotosho Moses Oluseyi Omotosho Moses Oluseyi , Edim Bassey Edim Edim Bassey Edim
Published: December 2024

In the era of Industry 4.0, the integration of
Machine Learning (ML) with the Industrial Internet
of Things (IIoT) has transformed predictive
maintenance into a powerful tool for enhancing
operational efficiency and minimizing unplanned
downtime. This study provides a comprehensive
comparative analysis of various machine learning
algorithms applied in predictive maintenance
within IIoT environments. We evaluate the
performance of algorithms such as Random Forest,
Support Vector Machines, Neural Networks, and
Gradient Boosting in terms of accuracy,
computational efficiency, and scalability. Our
research explores the nuances of these algorithms
when applied to different industrial datasets,
highlighting their strengths and limitations in realworld scenarios. Furthermore, we discuss the
practical applications of predictive maintenance in
diverse industrial sectors, emphasizing case studies
where specific ML techniques have led to
significant cost savings and operational
improvements. This study not only serves as a
guide for selecting appropriate ML algorithms for
predictive maintenance but also contributes to the
ongoing discourse on optimizing IIoT systems for
maximum reliability and efficiency. The findings
underscore the importance of algorithm selection
tailored to specific industrial needs and offer
actionable insights for practitioners and researchers
in the field.
Advanced Machine Learning – A Comprehensive Survey and New Research Directions
Authors: Akpan Itoro Udofot Akpan Itoro Udofot , Omotosho Moses Oluseyi Omotosho Moses Oluseyi , Edim Bassey Edim Edim Bassey Edim
Published: December 2024

This paper presents a comprehensive survey of
advanced machine learning techniques, focusing on
recent innovations and emerging research
directions. As machine learning continues to
evolve, significant strides have been made in areas
such as supervised, unsupervised, and
reinforcement learning, as well as deep learning
methodologies. This survey reviews the latest
advancements in these domains, highlighting novel
algorithms, hybrid models, and approaches
designed to enhance scalability and efficiency. We
also explore real-world applications and case
studies that illustrate the impact of these
advancements across various fields, including
healthcare, finance, and robotics. By synthesizing
current knowledge, this paper identifies key
challenges and gaps in the existing literature,
proposing new research directions that hold
promise for pushing the boundaries of machine
learning. Future research areas include the
development of more robust and interpretable
models, the integration of machine learning with
emerging technologies, and the exploration of
ethical considerations in algorithmic decisionmaking. This survey aims to provide a valuable
resource for researchers and practitioners seeking
to understand the state-of-the-art in machine
learning and to stimulate further investigation into
these promising new directions.
Improving the competitiveness of small and medium enterprises in Ho Chi Minh City
Authors: Bui Ngoc Hien Bui Ngoc Hien
Published: December 2024

In the context of an increasingly deeply integrated
economy, improving competitiveness is a vital
factor for small and medium enterprises. In Ho Chi
Minh City , small and medium enterprises play a
key role in the economy, not only contributing to
economic growth but also creating jobs and
promoting innovation. The performance of small
and medium enterprises directly affects the
competitiveness and economic development scale
of the city.The article analyzes the development
status of small and medium enterprises in Ho Chi
Minh City in the period of 2020-2023, clarifying
the challenges and opportunities that enterprises
face in the context of digital economy and global
integration. Based on this analysis, the author
proposes a number of specific solutions to improve
the competitiveness of small and medium
enterprises, from reforming support policies to
applying technology and improving management
capacity. These solutions are expected to contribute
to promoting the sustainable development of small
and medium enterprises and the common
prosperity of Ho Chi Minh City.
A Review on Statistical Models for Estimating Renewable Energy Production
Authors: Eti Jain Eti Jain , Prof. A.K. Sharma Prof. A.K. Sharma
Published: December 2024

The transition towards renewable
energy is no longer just an option but a necessity in
addressing the growing challenges of climate
change, environmental degradation, and energy
security. Fossil fuels, which currently dominate
global energy consumption, are finite and
contribute significantly to greenhouse gas
emissions. Shifting to renewable energy sources
such as solar, wind, hydropower, and biomass
offers a sustainable path forward, benefiting both
the environment and global economies. Despite its
benefits, the migration to renewable energy faces
challenges, including the need for substantial initial
investments, technological limitations, and
resistance from entrenched fossil fuel industries.
Governments, private sectors, and international
organizations must work together to create policies
and incentives that encourage renewable energy
adoption. Public awareness campaigns, subsidies,
and research funding are critical in overcoming
these barriers. To develop a sustainable renewable
energy infrastructure, we need to forecast the
amount of renewable energy production in future
and meet energy demands in future through
renewable sources. This paper presents a
comprehensive review of statistical models for
forecasting renewable energy along with associated
challenges that the sector faces.
An Examination into the Impact of Risk Management Techniques on Building Construction Projects
Authors: Obadimu Obadimu , Olawale Oladipupo Olawale Oladipupo , Ezeokoli Fidelis Okechukwu Ezeokoli Fidelis Okechukwu , Okoli Obuneme Godwin Okoli Obuneme Godwin , Oluwatayomi Daniel Fadumo Oluwatayomi Daniel Fadumo
Published: December 2024

This study examined the impacts of risk
management practice techniques in building
construction projects in Kwara State, Nigeria. A
survey design research approach was used, with
targeted professionals in the public and private
sectors. A total number of one hundred and
seventy-four (174) questionnaires were
administered but one hundred and thirty-six (136)
were returned valid. Data were analysed using
descriptive statistical mean scores, and standard
deviation. The outcome showed that most
professionals in building construction projects
adopted risk reduction, Risk difference, and risk
avoidance as their commonly used risk
management techniques.It further affirms that;
Impacts positively on building construction project
cost, improves program plan (time) of construction
project, and enhances construction project quality.
This is because, it gives a better project output in
terms of effective cost, timely delivery, and high
quality. Consequently, risk management technique
ensuring the entire process to minimize any
negative consequences in the course of building
construction process. The study concludes that risk
management techniques have great positive
impacts on the performance of projects in terms of
cost, time, and quality.The study recommend that,
the building contractors should pay critical
attention to the affirmed risk techniques in the
study area as a useful risk management technique
to handling their projects’ risk.
Predicting Effect of Refuse Dump on the Water Quality of Otamiri River
Authors: Nwakwasi L. N Nwakwasi L. N , Onosakponome O. R Onosakponome O. R , Onuoha O. I Onuoha O. I
Published: December 2024

This research is aimed at predicting effect of refuse
dump on the water quality of Otamiri River which
served for domestic uses among the rural
inhabitants. Anthropogenic activities that goes on
at its bank that serve as non-point source have
raised much concern about the water quality of the
river. Water samples were collected from nine (9)
spatially referenced points within the river using
the conventional WHO (2004) methods [1] and
analyzed in line with APHA standard procedures
for testing water in order to evaluate the water
quality status of Otamiri River. Spatial variations in
biological and physicochemical parameter were
observed across the sampling locations. Maximum
levels of pH and colour were recorded in sampling
Location 1 (5.7 and 17.5Pcu respectively).
Maximum levels of EC, Nitrate, Sulphate, TDS,
TSS and TS were recorded in sampling locations 3
with the average value (79 , 5.1225 mg/l
N0-
3 2.46mg/L, 52mg/L, 161mg/L and 109mg/L
respectively). Maximum levels of COD in Location
2 (684mg/L). Maximum levels of
Turbidity, , , DO and
(8.34NTU, 0.443 mg/L, 2.22 mg/l, 15.18 mg/L and
12.21 mg/L respectively) were recorded in
Location 5. The data analysis tool in Microsoft
Excel was used to explore and study the
interrelationship between the water quality index as
dependent variable and some conservative
parameters like (pH, EC, Tur, N0-3, TH, TDS,
, , DO, and COD) as
independent variables. Regression models were
developed and they will help in determining the
pollution concentration at any point within the
river. As constant dumping of refuse at the site has
increased the concentration of pollutants in the
river water, even though some remain within
established standards, water from Otamiri River
requires elaborate treatment before it could be
suitable for domestic purposes. Institutional and
social familiarities were identified as cause of poor
waste disposal problem
معوقات التدريب الفندقي لدى طلبة قسم العلوم الفندقية والسياحية في كلية العقبة الجامعية في جامعة البلقاءالتطبيقية وسبل التغلب علىها
Authors: المحاسنة محمد , الزيني ميادة
Published: December 2024

يمثل التدريب الفندقي حجر الزاوية في برامج الإعداد والتأهيل الوظيفي لأنه يساعد الطلبة المتدربين في التعرف على مشكلات مهنتهم والانتقال تدريجيا إلى التأقلم والتكيف معها، لذا هدفت الدراسة إلى التعرف على معوقات التدريب الفندقي لدى الطلبة، ومعرفة مقترحاتهم للتغلب على تلك المعوقات وإيجاد حلول لها لتحسين جودة التدريب الفندقي، واهتمت بتحسين جودة التدريب الفندقي لطلبة قسم العلوم الفندقية والسياحية، من خلال توفير التغذية الراجعة للقائمين على برامج التدريب الفندقي فى إبراز نقاط القوة والضعف فى برامجهم، ووضعت مقترحات لمعالجة المشكلات التى تواجه طلبة قسم العلوم الفندقية والسياحية أثناء التدريب الفندقي، واستخدمت المنهج الوصفى على عينة مقدارها (124) من طلبة التدريب الفندقي وطلبة الدبلوم بقسم العلوم الفندقية والسياحية بكلية العقبة بجامعة البلقاء بالمملكة الأردنية الهاشمية، وتم تصميم استبانة مكونة من ثلاثة أجزاء لتحقيق هدف الدراسة، وتوصلت إلى عدة نتائج أهمها: قلة العائد المادي مقابل الجهد المبذول من قبل الطلبة في التدريب، وتدني المهارات اللازمة لدى الطلبة للتغلب على مشكلات وضغوط التدريب، قلة المخصصات المإلىة التي توفرها الكلية لتحسين جودة عملية التدريب الفندقي للطلبة، ضعف التنسيق بين إدارة الكلية والفنادق بخصوص تسهيل عملية التدريب للطلبة، كما يتضمن البحث مجموعة من التوصيات لمختلف الأصعدة للطلبة مثل زيادة المخصصات المإلىة المخصصة للمتدربين، إضافة دورات أومقررات تساعد الطلبة على تطوير مهاراتهم فى حلول مشكلات التدريب التى تقابلهم.
Peculiarities of the legal status of immovable property of family members
Authors: Semenova Ekaterina
Published: December 2024

Introduction. The Russian lawmakers do not endow immovable property of family members with independent features of objectness, however, in family relations the realisation of rights to such property has a certain specificity, which is evident in the peculiarities of its purchasing and saling, realisation of the rights of the owner, as well as of the persons residing with him, restrictions of rights, protection measures, and the procedure for termination of rights. The purpose of the article is to develop theoretical provisions regarding the legal status of immovable property of family members, as well as practical recommendations aimed at further improvement of the current legislation. Methods. The research is based on the integrated use of dialectical method, which made it possible to reveal the peculiarities of the legal status of immovable property of family members, due to the identified specificity of the object and subject composition of relations, as well as the systematic approach, through which the legal status of immovable property of family members was analysed as a complex legal phenomenon, representing a set of legal means. Results. The legal status of immovable property of family members requires a systematic approach in ensuring the property interests of family members as a civil-law community, as well as public interests aimed at protecting the family, protecting the interests of particular family members unable to meet their own housing needs, and includes a set of legal means on the basis of which it is possible to own, use and dispose of a particular real property object.