bluuebunny/crossref_metadata_2025 huggingface dataset:
Total edge irregularity strength of some cycle related graphs
Authors: Rajendran Ramalakshmi , KM Kathiresan
Published: January 2022

An edge irregular total k-labeling f : V ∪ E → 1,2, ..., k of a graph G = (V,E) is a labeling of vertices and edges of G in such a way that for any two different edges uv and u'v', their weights f(u)+f(uv)+f(v) and f(u')+f(u'v')+f(v') are distinct. The total edge irregularity strength tes(G) is defined as the minimum k for which the graph G has an edge irregular total k-labeling. In this paper, we determine the total edge irregularity strength of new classes of graphs Cm @ Cn, Pm,n* and Cm,n* and hence we extend the validity of the conjecture tes(G) = max {⌈|E(G)|+2)/3⌉, ⌈(Δ(G)+1)/2⌉}  for some more graphs.
Relationship between adjacency and distance matrix of graph of diameter two
Authors: Chasanah Siti L. , Khairunnisa Elvi , Yusuf Muhammad , Sugeng Kiki A.
Published: January 2022

The relationship among every pair of vertices in a graph can be represented as a matrix, such as in adjacency matrix and distance matrix. Both adjacency and distance matrices have the same property. Adjacency and distance matrices are both symmetric matrix with diagonals entries equals to 0.  In this paper, we discuss relationships between adjacency matrix and distance matrix of a graph of diameter two, which is D=2(J-I)-A. From this relationship, we  also determine the value of the determinant matrix A+D and the upper bound of determinant of matrix D.
On local antimagic vertex coloring of corona products related to friendship and fan graph
Authors: Himami Zein Rasyid , Silaban Denny Riama
Published: January 2022

Let G=(V,E) be connected graph. A bijection f : E → {1,2,3,..., |E|} is a local antimagic of G if any adjacent vertices u,v ∈ V satisfies w(u)≠ w(v), where w(u)=∑e∈E(u) f(e), E(u) is the set of edges incident to u. When vertex u is assigned the color w(u), we called it a local antimagic vertex coloring of G. A local antimagic chromatic number of G, denoted by χla(G), is the minimum number of colors taken over all colorings induced by the local antimagic labeling of G. In this paper, we determine the local antimagic chromatic number of corona product of friendship and fan with null graph on m vertices, namely, χla(Fn ⊙ \overline{K_m}) and χla(f(1,n) ⊙ \overline{K_m}).
Charakter prawny odszkodowania należnego od osoby zajmującej lokal bez tytułu prawnego w świetle ustawy o ochronie lokatorów
Authors: Królikowski Mateusz
Published: January 2022

Niniejszy artykuł poświęcony został problematyce relacji cywilnoprawnej pomiędzy wynajmującym lokal mieszkalny a byłym najemcą wciąż zajmującym mieszkanie. Zgodnie z przepisami ustawy o ochronie praw lokatorów ten ostatni jest zobowiązany do zapłaty comiesięcznych świadczeń za okres pomiędzy zakończeniem obowiązywania najmu a wydaniem lokalu. W doktrynie oraz orzecznictwie przedmiotem dyskusji jest, czy płatności te powinny być traktowane jako odszkodowanie z tytułu korzyści utraconych przez wierzyciela na skutek brak terminowego zwrotu przedmiotu umowy czy też raczej jako świadczenie należne w ramach wciąż trwającego stosunku prawnego. Moim zdaniem, istotne znaczenie ma podział na lokale należące do gminnego zasobu mieszkaniowego oraz lokale prywatne. W odniesieniu do tej pierwszej, niewątpliwie szeroko rozpowszechnionej kategorii należy przyjąć, że sytuacja prawna byłego lokatora jest zbliżona do pozycji najemcy, o ile gmina jest zobowiązana do zawarcia z nim kolejnej umowy dotyczącej innego lokalu. W pozostałym jednak zakresie świadczenia należne byłemu wynajmującemu powinny być traktowane jako odszkodowanie z tytułu nienależytego wykonania kontraktu.
Management of Foreign Exchange Reserves of the European Central Bank
Authors: Sitek Paweł
Published: January 2022

The aim of the article is to analyze the foreign exchange reserves of the European Central Bank and the methods of their modern management. As a result of the study, it was proven that when implementing foreign reserve management policy, the European Central Bank and national central banks should pursue the objectives of the current monetary policy for future generations. Foreign exchange reserves are a special good that only the current generation and the current government cannot use. The character of the article implies different research methods: analysis of the sources of law, legal dogmatic, comparative dogmatic method. The analysis carried out as part of the study indicates that management of foreign exchange reserves of ECB has an impact on intergenerational justice.
Sebaceous Carcinoma of the Vulva: An Unexpected Diagnosis and Literature Review
Authors: Rocha Ana Carolina , Sá Maria Inês , Abrantes Carlos , Sousa Rita
Published: January 2022

Sebaceous carcinoma of the vulva is a rare malignancy of the sebaceous glands, with potentially aggressive behaviour, that is usually found in the peri-ocular area. Nonetheless, there are sebaceous glands in the vulva and this diagnosis is especially rare, with only ten cases described in the literature. We report a case of 78-year-old female patient who presented with vulvar pruritus, previously treated with topical steroid and antifungal treatments, without improvement. The vulvar examination showed a visible yellow papule, 12 x 10 mm on the right major labia, which was biopsied and the microscopic examination revealed an invasive sebaceous carcinoma of the vulva, with an in situ component. We performed an uneventful excisional biopsy, followed by a subsequent margin widening. Three months after the diagnosis, she presented with the first recurrence. Two and half years after the diagnosis, she recurred with a larger lesion (13 mm) in the upper half of small right lip, more than 10 mm away from the midline. In a multidisciplinary meeting it was decided that the patient should undergo partial right vulvectomy with homolateral inguino-femoral sentinel node biopsy (one negative node). There was no evidence of recurrence one-year post-surgery.
Estudio de perspectiva sobre la implementación de arquitectura adaptable en el mercado habitacional
Authors: Diaz de Leon Francisco Mercado , Padilla Lozano Fernando , López Alejandra Torres Landa
Published: January 2022

En los últimos años, se ha acrecentado el interés por reducir el consumo de recursos, para lograr un mayor nivel de sustentabilidad, una solución arquitectónica que esté preparada para cambiar sinérgicamente con los usuarios aumentando el ciclo de vida de los edificios y con esto, reduce su huella ambiental.
Cuando las personas buscan una vivienda recurren a distintas opiniones profesionales (arquitectos, valuadores, diseñadores, agentes de venta, etc.). Todos los involucrados en la definición de un edificio tienen intereses diferentes y posiciones distintas sobre la implementación de algún tipo de diseño arquitectónico. Los interesados juegan el papel de promotores o barreras para la implementación de arquitectura adaptable. (Schmidt III & Austin, 2016)
El presente documento, presenta el resultado de la exploración de la posición de una muestra de 142 arquitectos y diseñadores de vivienda, respecto a el conocimiento de conceptos de arquitectura adaptable y el interés de utilizarlos en sus proyectos. Los resultados muestran positivamente la disposición de implementar diseños adaptables en vivienda y las principales preocupaciones e incredulidades sobre la postura de otros interesados.
Apresentação
Authors: RUA Revista
Published: January 2022

Chegamos no segundo número do vigésimo sétimo volume da revista Rua, o quarto número publicado em meio à pandemia. Quase sem palavras e sem fôlego, ainda é preciso continuar, apesar de tamanho desassossego frente a tudo o que vivemos junto com a pandemia no Brasil e no mundo. As lutas são inúmeras e se travam em espaços múltiplos. Resistimos com a ciência, pela ciência, na manutenção da revista Rua com sua pungência porque traz à tela aquilo que normalmente não tem visibilidade em um mundo semanticamente estável; e com sua potência porque mobiliza compreensões fundamentais para que novas possibilidades de sentido se façam visíveis e desejadas. Gesto coletivo. Agradecemos aos autores, pareceristas e à equipe técnica por continuarem fazendo laço conosco nessa travessia! Muito obrigada!!
The Risk-Taking Behaviour of Tunisian Banks in the Post-Revolution Era: A Panel ARDL-PMG Approach
Authors: SAADAOUI Zied , MOKDADI Salma
Published: January 2022

This study investigates the long-term determinants of capital buffers and risk-taking adjustment by focusing on a sample of listed Tunisian commercial banks. This research uses hand-collected semi-annual data. The panel autoregressive distributed lags technique is used to control for unit root processes and to check for long-term determinants of capital and risk-taking adjustment. The empirical findings prove the existence of a moral hazard and procyclical behaviour of Tunisian banks in response to capital requirements. However, some results indicate that capital standards are still an important prudential tool for ensuring the robustness of Tunisian banks. There have been no previous studies focusing on this issue in the context of the Tunisian banking system in the turbulent post-revolution era. This paper innovates by assuming that a set of bank-specific, macroeconomic and regulatory variables exert a long-term rather than a short-term influence on capital buffers and risk-taking. The research does not consider a possible long-term simultaneous relationship between capital and risk-taking. The sample could be extended if data were available. Tunisian banks are advised to diversify their sources of revenues and to thoroughly revise their business models in order to become less dependent on revenues from traditional intermediation activities and to reduce the procyclicality of the banking system.
Quelles perceptions sociales de la forêt ? Aperçu des différentes approches à partir de l’analyse de la littérature
Authors: Lebreuilly Romain , Rigaux Nicolas , Batt Martine
Published: January 2022

Dans cette revue de littérature, nous récapitulons les courants théoriques majeurs qui s’attachent à étudier la forêt, entendue de manière générique, en sciences humaines et en psychologie en particulier soixante-dix études ont été identifiées et analysées afin de mettre en exergue les variables psychosociales majeures relatives à cet objet de recherche un défaut de modèle intégratif et la pertinence d’aborder la représentation sociale et ses effets de la coupe d’un arbre ressortent de cette étude.
Les ventes de bois des forêts publiques en 2020
Authors: Office national des forêts Direction Commerciale Bois et Services
Published: January 2022

L’impact économique de la crise sanitaire mondiale Covid et l’accentuation des dépérissements forestiers conduisent à un recul de 14% du chiffre d’affaires bois des forêts publiques Le prix des bois baisse de 10 %en moyenne, et de 17% pour l’Épicéa avec plus de bois scolytés qu’en 2019 Le Hêtre, le Sapin, le Pin sylvestre et même le Chêne sont victimes de cette troisième année consécutive chaude avec une grande sécheresse d’été Depuis début 2020, toutes les ventes par soumission sont faites avec un outil évolutif de vente en ligne Elles sont principalement complétées par les contrats d’approvisionnement, toujours en croissance et représentant 35% des volumes mobilisés.
Empreinte carbone de la forêt et de l’utilisation de son bois
Authors: Leturcq Philippe
Published: January 2022

Une idée répandue est que le remplacement par du bois des combustibles fossiles et des matériaux énergivores est une meilleure stratégie pour atténuer le changement climatique que le stockage de carbone dans les forêts. Cette opinion découle de l’assertion de « neutralité carbone de la biomasse » à laquelle se réfèrent, à tort, les politiques forestière et énergétique d’un grand nombre de pays, notamment en Europe. Les objections de nombreux scientifiques sont restées jusqu’à présent sans effet, sans doute par manque d’une description suffisamment simple, compréhensible par tous, de la véritable empreinte carbone des produits ligneux récoltés. Cet article montre, à partir des fondamentaux, que l’augmentation de la récolte et des usages du bois est contre-productive pour les objectifs d’atténuation du changement climatique, notamment lorsque le bois est utilisé comme combustible.
ELID Mirror Surface Grinding for Concave Molds by Conductive Elastic Wheel Containing Carbon Black
Authors: Ezura Atsushi , Inazawa Katsufumi , Omori Kazuhiro , Uehara Yoshihiro , Itoh Nobuhide , Ohmori Hitoshi ,   Kanazawa University Kakuma-machi, Kanazawa-shi, Ishikawa 920-1192, Japan,   Industrial Technology Center of Tochigi Prefecture, Utsunomiya, Japan,   RIKEN, Wako, Japan,   Ibaraki University, Hitachi, Japan
Published: January 2022

Elastic grinding wheels have previously been adopted for the development of the mirror surface finishing method for concave spheres. In this study, new conductive elastic grinding wheels, to which electrolytic in-process dressing (ELID) can be applied, are developed; the aim of the study is to address the challenge of maintaining a constant removal rate for rubber bond wheels. When ELID grinding is performed using a non-diene (isobutane isoprene rubber, IIR)-based wheel, a larger removal amount is achieved, and a higher-quality surface is also achieved compared to a diene (acrylonitrile-butadiene rubber, NBR)-based wheel. In addition, to investigate the effect of grinding wheel bond hardness on the removal amount and ground shape accuracy, grinding wheels with various levels of hardness are prepared by controlling the amount of carbon black contained in them, and grinding experiments are conducted. Thus, a larger removal amount is achieved using a harder grinding wheel, but the roughness of the ground surfaces deteriorates. Therefore, in practice, it is necessary to select an appropriate grinding wheel that can achieve both productivity and surface quality. Finally, to obtain a high-quality mirror finish on a concave spherical surface, ELID grinding is performed on the workpieces as is done for spherical lens molds. Thus, high-quality mirror surfaces with roughness Ra < 10 nm were generated. When the work pieces are ground using a grinding wheel of the same radius, excessive removal occurs at the edge of the concave spherical profile, decreasing the form accuracy. Numerical simulation demonstrates that chamfering of the grinding wheel is effective for improving the shape accuracy. The results of this study are expected to contribute to automation and cost reduction in the mirror-finishing process for concave molds.
Development of Ultrasonic Vibration-Assisted Magnetic Compound Fluid (MCF) Polishing Technology
Authors: Nomura Mitsuyoshi , Ozasa Kenji , Fujii Tatsuya , Suzuki Tsunehisa , Wu Yongbo ,   Department of Mechanical Engineering, Akita Prefectural University 84-4 Ebinokuchi, Tsuchiya, Yurihonjo, Akita 015-0055, Japan,   Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, China
Published: January 2022

This study investigates the development of an ultrasonic vibration-assisted magnetic compound fluid (MCF) polishing technology for final polishing. The fabrication of an experimental apparatus entails an ultrasonic polishing unit, and the experimental investigation of its performance in surface polishing is described. In addition, ultrasonic vibration-assisted MCF polishing under different applied methods of ultrasonic vibration is studied. The experimental results indicate that applying ultrasonic vibration to the workpiece improves the surface roughness and material removal rate when the ultrasonic vibrations are changed. In addition, across the range of polishing conditions employed in this study, the precision surface roughness and high material removal rate can be easily obtained on the acrylic plate by applying an elliptical vibration to the ultrasonic vibration.
Rotary Cutting with Ultrasonic Vibration of Hardened Steel
Authors: Ninomiya Shinichi , Nagakura Satoshi , Koga Fumio , Yamada Yoji , Iwai Manabu ,   Nippon Institute of Technology 4-1 Gakuendai, Miyashiro-machi Saitama 345-8501, Japan,   Koga Co., Ltd., Kanuma, Japan,   Toyama Prefectural University, Imizu, Japan
Published: January 2022

We propose ultrasonic rotary cutting, in which ultrasonic vibrations are imparted to a rotating cemented carbide cylindrical tool to cut hardened steel to reduce the cutting resistance and improve the properties of the machined surface, and investigate the machining characteristics. Machining experiments were conducted under dry and wet conditions to verify the effects of the ultrasonic vibrations. The surface produced via ultrasonic rotary cutting was intermittently machined, which is characteristic of ultrasonic cutting. In dry machining, the cutting resistance was reduced by approximately 20%, and the surface roughness of the machined surface was reduced by approximately 30% when the cutting speed was below the critical speed. We also demonstrated that the surface roughness was improved by ultrasonic vibrations when the cutting speed was equal to or above the critical speed. A similar tendency was observed in wet machining with longer cutting lengths. We then applied ultrasonic rotary cutting to machine a straight R groove in hardened steel and showed that the cutting resistance was reduced, and the tool engagement was improved.
In Search of Moderation of Islam Againts Extremism: A Promoting “Islam Pribumi” By Gus Dur
Authors: Muzayyin Muzayyin , Kartika Nadia Raifah Nawa , Habib Habib
Published: January 2022

Indonesian religious expressions are facing an extraordinary challenge with the emergence of fundamentalist movements affiliated with number of Islamic transnationalist from Middle East, which is rigidly establishing the ideology of "purification" or as so called Islam Kaffah even if to be forced to the all nation. In this Case, Gus Dur presented another alternative religious pattern by promoting the idea of Islam Pribumi or “Islam Pribumi” which mean to respon and againts this scripturalist-fundamentalist movement. Islam Pribumi is intended to provide opportunities for the diversity of interpretations in term of practicing religious life (Islam) in each different region. Thus, Islam is no longer seen as a single, but rather compound. So there is no longer an assumption that Islam in the Middle East is the best representative of Islam. Therefore, this paper attempts to examine Gus Dur's thoughts on Islam Pribumi which is definitly inclusive, tolerant and peaceful Islamic culture, relflecting Islam as rahmatal lil alamin. It is also to offer a model of Islamic Moderation provided a solution in realizing global peace against conflicts between religions and politics that has occurred most recently in a Muslim-majority country like Syria, Afghanistan, Iraq, and Yemen.
Kekhilafahan Islam, Globalisasi dan Gerilya Maya: Studi Kasus Hizbut Tahrir Indonesia
Authors: Setia Paelani , Rahman M. Taufiq
Published: January 2022

This paper aims to explain the role of radical Islamic organizations in the era of globalization. The case study taken in this research is Hizbut Tahrir Indonesia (HTI). As a transnational organization, Hizb ut-Tahrir grew and crossed national boundaries, including arriving in Indonesia and playing an essential role in shaping public opinion in Indonesia. This study uses qualitative research methods to collect data through online observation, which is described by content analysis. The findings of this study are Hizb ut-Tahrir Indonesia is part of the players of globalization. This is evidenced by the organization's involvement in 50 countries and five continents globally supported by their global media. In Indonesia, although the Government disbanded it in 2017, Hizb ut-Tahrir's activities are still strengthened and maintained through globalization instruments such as the internet. HTI then carried out virtual guerrilla activities to keep the idea of a caliphate grounded.
Treatment of Overweight and Obesity by Suppressing Intestinal Epithelial Renewal in a Mouse Model of Obesity
Authors: Zeng Wei-ping
Published: January 2022

Obesity and overweight pose serious risk for many diseases and clinical conditions.However currently available weight loss strategies and pharmacotherapies of obesity are notsatisfactory. This study shows that treatments with pH modifiers such as acids are not only welltolerated by obese mice but also very effective in reducing bodyweight and fat mass by depletingand suppressing the proliferation of proliferating epithelial cells of the intestinal villi. Thereforeother cell proliferation inhibitors that suppress intestinal epithelial renewal can also be used forpharmacotherapy of obesity and overweight.
Reduction of Pulmonary Inflammation by pH Modifiers
Authors: Zeng Wei-ping
Published: January 2022

Pulmonary inflammation is a common pathological feature of a variety of diseases, ofwhich successful therapy with currently available anti-inflammatory drugs is limited byresistance and adverse side effects. Using the ovalbumin-induced mouse allergic asthma model,the present study shows that treatments with pH modifiers, particularly simple acids such asacetate or hydrochloric acid, effectively depleted inflammatory cells in the lungs and blood aswell as hyperplastic lung tissue cells while preserving the structure of the blood vessels and lungparenchyma. The acid treatments also suppressed mucus hypersecretion. These resultsdemonstrated pH modifiers as a new class of broad-spectrum anti-inflammatory agents with antiproliferationand mucus suppression activities.
Understanding of Controllable Optical Memory Using 1D Inp Based Photonic Structures at Three Communication Windows
Authors: M Rajesh Khanna , Appathurai Karthikeyan , G Kuppusamy P , R Prianka R
Published: January 2022

The present research realises a controllable optical memory using one dimensional indium phosphate (InP) photonic structures at three optical communication windows (850 nm, 1310 nm and 1550 nm). The photonic structures comprise 21 layers of InP and air material. The memory applications are realised at both single and dual signals of the communication windows. The physics of the research deals with the materials property including the variation of the refractive indices with respect to the input signal. Similarly, mathematics of the works relies on the analysis of reflectance, transmittance and absorbance phenomena. Further, the light from visible spectrum acts as triggering signal to realise optical memory applications. Finally, it is revealed that InP based photonic structures are suitable for controllable memory applications pertaining to the single wavelength (850 nm, 1310 nm, 1550 nm) or dual wavelengths (850 nm and 1310 nm, 1310 nm and 1550 nm, 1550 nm and 850 nm).
Pediatric Resident Education in Pediatric Cardiology – A Needs Assessment
Authors: Hovis Ian W. , Frank Lowell H. , Gordish-Dressman Heather , Spurney Christopher F.
Published: January 2022

Background: Although congenital heart disease is the most common human birth defect, the scope and breadth of pediatric cardiology is far more diverse. Additionally, there continues to be rapid advancements in the field with educators becoming increasingly sub-specialized. As such, determining the topics general pediatric residents are taught must be selected based on numerous factors including resident career goals, core topics for board exams, and educator preferences. This study aimed to determine if the educational needs of general pediatric residents are met while on a pediatric cardiology rotation. Methods: All PL-2 and PL-3 residents in the Children’s National Hospital pediatrics residency program who had completed a required cardiology rotation as well as all pediatric cardiology fellows and pediatric cardiology attendings were asked to complete a survey. Participation in the study was voluntary. Respondents were asked to answer questions related to the perceived effectiveness and applicability of the currently administered cardiology curriculum, specifically inquiring about methods of teaching, the level taught, and the utility of topics selected. Results: Twenty-four (31%) of the 77 eligible residents completed the survey. Fourteen (82%) of the eligible attendings and nine (75%) of the cardiology fellows completed the survey. Seventeen unique topics in pediatric cardiology were ranked. The highest rated topics based on both perceived needs and wants included congenital heart disease, murmurs, cardiac physiology, ECG interpretation, and syncope/dizziness. Participants reported the highest satisfaction for whiteboard and bedside teaching. Conclusions: Overall, general pediatrics residents were satisfied with the current educational design of the inpatient cardiology rotation. These data provide a framework, both in teaching modalities and core concepts, for continued development and reassessment of inpatient pediatric cardiology rotations to optimally prepare pediatric residents with a strong foundation in pediatric cardiology.
Clinical and Pathological Features of Immune-Mediated Necrotising Myopathies in a Single-Centre Muscle Biopsy Cohort
Authors: Yang Hongxia , Tian Xiaolan , Zhang Lining , Li Wenli , Liu Qingyan , Jiang Wei , Peng Qinglin , Wang Guochun , Lu Xin
Published: January 2022

Objective

Immune-mediated necrotising myopathy (IMNM) is a recently entitled novel subset of idiopathic inflammatory myopathies (IIM) characterized by significant elevated creatine kinase (CK) level, muscle weakness and predominant muscle fibre necrosis in muscle biopsy. This study aimed to investigate the clinical and pathological characteristics of patients with IMNM in our single-centre muscle biopsy cohort.
Methods

A total of 860 patients who had muscle biopsy reports in our centre from May 2008 to December 2017 were enrolled in this study. IMNM was diagnosed in according with 2018 European Neuromuscular Centre (ENMC) clinicopathological diagnostic criteria for IMNM.
Results

The muscle biopsy cohort consisted of 531 patients with IIM (61.7%), 253 patients with non-IIM (29.4%), and 76 undiagnosed patients (8.8%). Among IIM patients, polymyositis (PM), dermatomyositis(DM), amyopathic dermatomyositis, juvenile DM, and inclusion body myositis were 182(21.2%), 236(27.4%), 83(9.7%), 18(2.1%) and 3(0.3%), respectively. In PM subgroup, 59 patients met serological and pathological characteristics of IMNM according to 2018 ENMC criteria including 29 anti-SRP-positive patients,10 anti-HMGCR-positive patients and 20 MSA-negative patients. Limb girdle muscular dystrophy (LGMD) 2B and lipid storage myopathy (LSM) were 29 and 16 respectively, which present similar manifestations of IMNM with elevated CK levels and muscle weakness among non-IIM group. IMNM patients had older age of onset (mean: 42.25 vs 21.66 and 24.56, p<0.0001), shorter duration of diseases (mean: 22.56 vs 66.69 and 48.94, p<0.0001) and more frequent of dysphagia (33.9% vs 3.4% and 6.3%, p<0.0001) compare to patients with LGMD 2B and LSM. Muscle biopsy from IMNM patients showed frequent muscle fibre necrosis (96.6% vs 72.4% and 56.3%, p<0.0001), overexpression of MHC-I on sarcolemma (81.4% vs 37.9% and 12.9%, p<0.0001) and CD4+ T cell endomysial infiltration (89.9% vs 53.6% and 50%, p<0.0001) compared with LGMD 2B and LSM patients.
Conclusions

It is easy to distinguish IMNM from other subtype of IIM according to clinical symptoms and MSAs profiles. However, distinguishing IMNM from disorders clinically similar non-IIM need to combine with clinical, serological and pathological features.
Erythemal UV Dose and UV Index Measurement at 37th North Latitude and Its Possible Effects on Humans
Authors: Emrahoglu Nuri
Published: January 2022

In this study, UV irradiance and UV erythemal and UV index data of May, June, July and August measured in Adana (longitute=36 E, latitute=37 N altitute=140m) between 2013 and 2019 were analyzed. As a result of the analysis, the average of four months was 14.16 MED (2.9736 J/m2) and the highest value of these four months was calculated as 15.6 MED (3.276 J/m2) in July. The percentage frequency of the total daily UV dose was also calculated and it was determined that the region was under the effect of 70-80% high UV dose. In addition, it was calculated to have a high UV index according to local time (10.00-14.00). It was concluded that this situation poses a great risk for workers working in agricultural areas in the region and for people who spend their summer holidays by the sea. UV Dose-Ozone, UV Dose-temperature, UV Dose-humidity and Ozone-temperature correlations were also calculated. As a result of the comparison, it was found that there was an R= -0.64 correlation between UV-ozone, an R= -1.00 correlation between temperature and ozone, and a direct correlation of R= 0.60 between UV radiation and temperature.
Significance of HMMR Overexpression in Hepatocellular Carcinoma
Authors: Zhao Weidong , Zhang Zhengxiang
Published: January 2022

Background: Hyaluronan Mediated Motility Receptor (HMMR), as one of the key surface binding proteins of HA, is up-regulated in many tumors. What’s more, the expression level of HMMR is usually correlate with tumor progression and prognosis. However, the relationship between the expression of HMMR and the prognosis and immune infiltration of hepatocellular carcinoma (HCC) is still unclear.Methods: We analyzed the expression level of HMMR by TIMER database, GEO database and GEPIA database. The correlation between the HMMR expression and tumor prognosis was analyzed via the Kaplan-Meier plots. The TIMER database and GEPIA database were used to study the relationship between HMMR expression and immune infiltration. GO and KEGG enrichment analysis were used to explore the potential biological functions of HMMR.Results: HMMR expression was significantly higher in several human cancers, including HCC, than in corresponding normal tissues. High HMMR expression associated with poorer overall survival, disease-specific survival, progression-free survival and relapse-free survival in HCC patients. HMMR showed strong correlation with tumor-infiltrating B cells, CD4 + and CD8 + T cells, macrophages, neutrophils, and dendritic cells. Several immune marker genes expression, including CD86, IRF5, CD11b, KIRIDL4, CD11c, IFN-γ, STAT3, STAT5B, and CTLA4, have markedly positive correlations with HMMR expression. Enrichment analysis found that HMMR is mainly involved in cell cycle, DNA replication and repair, PLK1 pathway, E2F pathway, ATR pathway and AURORA B pathway.Conclusions: HMMR is a potential prognostic biomarker that influence tumor progression and correlated with tumor immune cells infiltration in HCC.
Blood Transfusion Has An Adverse Impact On The Prognosis of Patients Receiving Chemotherapy For Advanced Colorectal Cancer: Experience From a Single Institution With a Patient Blood Management Program
Authors: Lim Ah Reum , Kim Jwa Hoon , Hyun Myung Han , Chang Won-Jin , Lee Soohyeon , Kim Yeul Hong , Park Kyong Hwa , Park Jong Hoon
Published: January 2022

Purpose: Perioperative blood transfusion in early stage cancer patients had a negative effect on the prognosis of patients, but the prognostic impact of transfusion in advanced cancer patients remains unclear. To minimize transfusion, a institutional patient blood management (PBM) program was launched, and we evaluated the new program has changed practice and impacted on prognosis of advanced cancer patients. Methods: We investigated the medical records of colorectal cancer patients who received chemotherapy from 2015 to 2020. The amount and frequency of transfusion, iron replacement and laboratory findings, and overall survival were compared before and after implementation of PBM. Results: The rate of transfusion in colorectal cancer patients was significantly decreased from 23.5/100 person-quarter in 2015 to 1.2/100 person-quarter in 2020, but iron supplementation therapy was frequently used and the proportion of patients who received transfusion under haemoglobin 7 g/dL significantly increased from 15.9% in 2015 to 55.3% in 2020. Multivariate analysis revealed that transfusion was a significant risk factor affecting the overall survival of patients (HR 2.70, 95% CI: 1.93–3.78, p<0.001). Kaplan–Meier analysis revealed that overall survival was significantly longer in non-transfused patients than in transfused patients (11.0 versus 22.4 months; HR 0.69, 95% CI: 0.56–0.86, p<0.001). Conclusions: This study shows that minimized transfusion through an institutional PBM can positively affect the prognosis of patients who are receiving chemotherapy for advanced colorectal cancer.
Characteristics of Three Organic Fertilizers and Their Influence on the Mobility of Cadmium and Arsenic in a Soil-Rice (Oryza Sativa L.) System
Authors: Tan Xiao , Cao Jinman , Liu Jiahao , Wang Jinhang , Duan Guilan , Zhang Yinjie , Lin Aijun
Published: January 2022

The properties and effects of organic fertilizers are different, including the ability to improve soil fertility and the potential of stabilizing heavy metals in soils that have not been explored in depth. In this study, three organic fertilizers from different raw materials were characterized and evaluated. The mushroom residue organic fertilizer (MO) had higher C, H, and O contents and more functional groups (-OH, C-H, and C=O), and its application significantly increased pH (1.00~1.32 units), organic matter (OM) content (26.58%~69.11%) and cation exchange capacity (CEC) (31.52%~39.91%) of soil. MO treatment also reduced the toxicity characteristic leaching procedure (TCLP)-Cd (24.21%) and TCLP-As (18.44%) concentration in the soil. That inhibited the mobilization of Cd and As from soil to plant, especially to plant shoots, and positively affected the plant growth and biomass. Redundancy analysis (RDA) showed that 40.09 % of total plant variation was related to soil properties (pH, OM, and CEC). Furthermore, the heavy metal risk assessment for all organic fertilizers was at safe levels. This study provides a valuable reference for the selection of organic fertilizers. Besides, it recommends organic fertilizers as economic and multi-effect amendments with safe use and provides a new option for the ‘simultaneous production and remediation’ of farmlands with low pollution.
Feasibility of Diffusion Kurtosis Imaging in Evaluating Cervical Spinal Cord Injury in Multiple Sclerosis
Authors: Bian BingYang , Liu ZhuoHang , Shao ZhiQing , Tian Pu , Liang YaQian , Zhu XiaoNa , Jie YiGe , Li Dan
Published: January 2022

Background：Quantitative evaluation of cervical spinal cord (CSC) injury in multiple sclerosis has always been a difficulty. The present study aimed to evaluate the lesion, normal-appearing gray matter (GM) and white matter (WM) damage, and therapeutic effect using diffusion kurtosis imaging (DKI) on CSC of patients with multiple sclerosis.Methods: A total of 48 patients with MS and 30 healthy adults, underwent routine MR scan and DKI of CSC. DKI-metrics were measured in the lesions and in the normal-appearing gray and white matter. MS patients were divided into those with and without T2-hyperintense lesions. Disability was assessed by the expanded disability status scale before and after therapy.Results：1) Significant differences were detected in MK, MD, and FA values between patients and healthy subjects (P < 0.05) and between patients with CSC T2-hyperintense and patients without T2-hyperintense (P < 0.05); 2) Compared to healthy, GM-MK and WM-FA were statistically reduced in patients without T2-hyperintense (P < 0.05). 3) Significant differences were observed in MK, MD, and FA between patients with T2-hyperintense after therapy (P < 0.05), as well as GM-MK and WM-FA in patients without T2-hyperintense (P < 0.05); 4) EDSS was correlated with MK values, as well as EDSS scores and MK values after therapy.Conclusions：1) DKI-metrics can detect and quantitatively evaluate the changes in cervical spinal cord micropathological structure; 2) MK values are sensitive metrics to detect the damage of gray matter; 3) MK values quantitatively evaluate the clinical disability progression and the therapeutic effect in MS patients.
Deformation Behavior and Damage-Induced Permeability Evolution of Sandy Mudstone Under Triaxial Stress
Authors: Liu Yang , Zhang Tong , Ma Yankun , Song Shuaibing , Tang Ming , Li Yanfang
Published: January 2022

The permeability and mechanical behavior in sandy mudstone are crucial to the hazard prevention and safety mining. In this study, to investigate the evolution and characteristic of permeability and mechanical properties of mudstone during the in-site loading process, triaxial compression-seepage experiments were performed. The increase of permeability and decrease of mechanical strength gradually evaluated to the decrease of permeability and increase of mechanical strength subjected to the increase of confining stress from 5 to 15 MPa, which corresponds to the transformation from brittleness to ductility of mudstone, and the transformation threshold of 10 MPa confining stress was determined. The shear fractures across the sample at brittle regime, while shear fracture does not cross the sample or even be not generated at semibrittle and ductile state. The dynamic decrease, slight decrease, and residual response were determined in axial strain, and the divided zone increases with the increase of confining stress. The relatively higher permeability corresponds to the higher pore pressure as the increase of confining stress. The volumetric strain increases as the increase of confining stress, compared to that decrease correspond to the increase of the pore pressure, and the higher volumetric strain and the lower permeability. In addition, an improved permeability model was developed to describe the loading-based permeability behavior considering the Klinkenberg effect.
Failure Properties and Stability Monitoring of Strip and Column Cemented Gangue Backfill Bodies Under Uniaxial Compression In Constructional Backfill Mining
Authors: Ran Hongyu , Guo Yuxia , Feng Guorui , Li Chunqing
Published: January 2022

The strip and column cemented gangue backfill bodies (CGBBs) are the main supporting components in the design of constructional backfill mining for coal mining, which determines the stability of goaf. Previous researches have mostly focused on the mechanical properties of column CGBB, but the mechanical properties of strip CGBB are still unclear. Herein, the uniaxial compression experiments for strip and column CGBBs were conducted to compare the failure properties. The acoustic emission (AE) and two types of resistivity monitoring were used to monitor the damage evolution. The effect of the length-height ratio on the mechanical characteristic of strip CGBB was analyzed by discrete element simulation. The results show that: the strength and peak strain of strip CGBB under uniaxial compression is higher than those of column CGBB, and the strip CGBB shows better ductility. The stress of column CGBB decreases significantly faster than that of strip CGBB at the post-peak stage. The strength and ductility of strip CGBB increase with the increase of length-height ratio. The strip CGBB is destroyed from both ends to the middle under uniaxial compression, and the core bearing area is reduced correspondingly. The AE signal evolution of CGBBs under uniaxial compression before the peak stress contains three stages, and the AE signals of strip CGBB at the peak stress will not rise sharply compared with column CGBB. The resistivity monitoring effect of the horizontally symmetrical conductive mesh is better than that of the axial. The horizontal resistivity increases gradually with the increase of stress under uniaxial compression, and increases sharply at the peak stress, and then drops after the peak stress. The damage constitutive models and the stability monitoring models of the CGBBs are established based on the experimental results. This work would be instructive for the design and stability monitoring of CGBB.
Effects of Tillage and Cropping Sequences On Crop Production And Environmental Benefits in the North China Plain
Authors: Liu Wen-Xuan , Liu Wen-Sheng , Yang Mu-Yu , Wei Yu-Xin , Chen Zhe , Virk Ahmad Latif , Lal Rattan , Zhao Xin , Zhang Hai-Lin
Published: January 2022

The ever-increasing trend of greenhouse gas (GHGs) emissions is accelerating global warming and threatening food security. Environmental benefits and sustainable food production must be pursued locally and globally. Thus, a field experiment was conducted in 2015 to understand how to balance the trade-offs between agronomic productivity and environment quality in the North China Plain (NCP). Eight treatments consisted of two factors, i.e., (i) tillage practices: rotary tillage (RT) and no-till (NT), and (ii) cropping sequences (CS): maize-wheat-soybean-wheat (MWSW), soybean-wheat-maize-wheat (SWMW), soybean-wheat (SW), and maize-wheat (MW). The economic and environmental benefits were evaluated by multiple indicators including the carbon footprint (CF), maize equivalent economic yield (MEEY), energy yield (EY), carbon sustainability index (CSI), etc. Compared with NT, RT increased the EY and MEEY, but emitted 9.4% higher GHGs. Among different CSs, no significant reduction was observed in CF. The lowest (2.0 Mg CO2-eq ha-1 yr-1) and the highest (5.6 Mg CO2-eq ha-1 yr-1) CF values were observed under MW and SWMW, respectively. However, CSs with soybean enhanced MEEY and the net revenue due to its higher price compared to that of MW. Although the highest CSI was observed under RT-MW, soybean-based crop rotation could offset the decline in CSI under NT when compared to that for RT. These findings suggest that conservation agriculture (CA) could enhance the balance in trade-offs between economic and environmental benefits. Additional research is needed on how to achieve high crop production by establishing a highly efficient conservation agriculture system in the NCP.
Research on the Relationship Between Self-Management Efficacy and Quality of Life for Breast Cancer Patients Receiving Endocrine Therapy
Authors: Yi Hongjie , Jiang Haoran , Wang Aiping , Zong Wei , Dong Yu , Li Yao
Published: January 2022

Purpose

To investigate the status quo and relationship between self-management efficacy and quality of life (QOL) of patients with breast cancer undergoing endocrine therapy, and to explore the influencing factors of QOL.
Methods

The convenience sampling method was used to select 240 patients who received endocrine therapy after breast cancer surgery in the First Hospital of China Medical University, the self-designed general data questionnaire, self-management efficacy questionnaire for breast cancer patients with endocrine therapy and quality of life scale for breast cancer patients were used to investigate. The frequency, percentage, mean ± standard deviation were used to describe patients' self-management efficacy and quality of life. Pearson correlation analysis was used to analyze the relationship between self-management efficacy and quality of life, and univariate analysis and multiple stepwise regression were used to analyze the influencing factors of QOL.
Results

The scores of self-management efficacy and QOL of patients with breast cancer endocrine therapy were 125.21 ± 25.57 and 153.33 ± 19.31 respectively, which were at the middle level; self-management efficacy was significantly positively correlated with quality of life ( p < 0.01 ) ; multiple stepwise regression results showed that self-management efficacy, the number of physical symptoms, monthly family income and recurrence and metastasis were the influencing factors of QOL.
Conclusion

The self-management efficacy of endocrine therapy was positively correlated with QOL in breast cancer patients. The higher the self-management efficacy of endocrine therapy, the better QOL in breast cancer patients. Self-management efficacy is the main factor affecting the quality of life of breast cancer patients undergoing endocrine therapy. Improving the level of self-management efficacy can improve their quality of life.
Designing a New Multi-Echelon Multi-Period Closed-Loop Supply Chain Network by Forecasting Demand Using Time Series Model: A Genetic Algorithm
Authors: Safaei Shahab , Ghasemi Peiman , Goodarzian Fariba , Momenitabar Mohsen
Published: January 2022

In the closed-loop supply chain, demand plays a critical role. The flow of materials and commodities in the opposite direction of the normal chain is inevitable too. So, in this paper, a new multi-echelon multi-period closed-loop supply chain network is addressed to minimize the total costs of the network. The considered echelons include suppliers, manufacturers, distribution centers, customers, and recycling and recovery units of components in the proposed network. Also, a linear programming model considering factories' vehicles and rental cars of transportation companies is formulated for the proposed problem. Moreover, the products demand is predicted by Auto-Regressive Integrated Moving Average (ARIMA) time series model to decrease the amount of shortage may happens in the network. To solve the proposed model, GAMS software is used in small-sized problems and a genetic algorithm in large-sized problems is employed. Numerical results show that the proposed model is closer to the real situation and the proposed solution method is efficient. Accordingly, sensitivity analysis is performed on important parameters to show the performance of the proposed model.
Determination of the Area of Energy-efficient Working Equipment Position and Effective Digging Radius of Hydraulic Excavators in Open-pit Mining
Authors: Markov Sergey , Tyulenev Maxim
Published: January 2022

Since the end of the last century, a significant number of hydraulic excavators have arrived on Russian quarries. Most of these excavators are equipped with backhoe operating equipment. The widespread use of such excavators in open-pit mining proves their exceptional efficiency. However, at the same time there is no clear understanding of the conditions under which a hydraulic excavator will be most effective: a theory of the face block of hydraulic shovels has not yet been developed. The available scientific studies are limited to determining the rational height of the excavation layer for efficient operation. If to take the quality of preparation of rock mass and the scheme of its loading into dump trucks as external parameters, i.e. not depending on the features of excavator design, then the position of its working equipment relative to the rock block has a decisive influence on operation of the hydraulic drive and fuel consumption. This is due to the changing value of digging force at various points of the bucket teeth position in the range of their possible positions at constant power of the hydraulic drive. Thus, application of optimal position of hydraulic excavator working equipment elements (bucket, arm, and boom) relative to the rotary platform and the rock massive during the digging cycle allows both to reduce fuel consumption and to increase the digging force. The application of the developed methodology is promising in terms of improving the energy efficiency of both individual excavation and loading units and the enterprise as a whole.