bluuebunny/crossref_metadata_2025 huggingface dataset:
Mental health problems and associated school interpersonal relationships among adolescents in China: a cross-sectional study
Authors: Li Jiayu , Li Jing , Jia Ruixia , Wang Yingquan , Qian Sheng , Xu Yong
Published: March 2020

Background

During adolescence, middle school students facing psychophysical changes are vulnerable to psychological problems. The present study aimed to investigate mental health status and associated school interpersonal relationships among adolescents in China, which may help to inform effective prevention strategies to reduce the prevalence of mental health problems.

Methods

In the cross-sectional study, a total of 10,131 middle school students were selected from three cities in eastern China by stratified random sampling. The Symptom Checklist-90 (SCL-90), Teacher–Student Relationship Questionnaire (TSRQ) and Peer Relationship Scale (PRS) were used to evaluate psychological symptoms, the quality of relationship with teachers and the quality of relationship with peers, respectively. Multivariable logistic regression analysis was conducted to explore the association between school interpersonal relationships and mental health problems in adolescents.

Results

36% of the middle school students reported positive in mental health problems assessed by the SCL-90. The most prevalent dimensional symptom was obsessive–compulsive (43.3%). The risk of all types of psychological symptoms was significantly associated with school interpersonal relationships. Moreover, a higher risk of mental health problems was associated with poorer school interpersonal relationships.

Conclusions

Mental health problems were prevalent among adolescents and highly associated with school interpersonal relationships. Our findings underscore the pressing need for school administrators to make efforts to improve school interpersonal relationships among adolescents.
The design and development of covalent protein-protein interaction inhibitors for cancer treatment
Authors: Cheng Sha-Sha , Yang Guan-Jun , Wang Wanhe , Leung Chung-Hang , Ma Dik-Lung
Published: March 2020

Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibition of PPIs has attracted significant attention in drug discovery. Covalent inhibitors have been reported to achieve high efficiency through forming covalent bonds with cysteine or other nucleophilic residues in the target protein. Evidence suggests that there is a reduced risk for the development of drug resistance against covalent drugs, which is a major challenge in areas such as oncology and infectious diseases. Recent improvements in structural biology and chemical reactivity have enabled the design and development of potent and selective covalent PPI inhibitors. In this review, we will highlight the design and development of therapeutic agents targeting PPIs for cancer therapy.
circFOXM1 promotes proliferation of non-small cell lung carcinoma cells by acting as a ceRNA to upregulate FAM83D
Authors: Yu Chengtao , Cheng Zhuoan , Cui Shaohua , Mao Xiaowei , Li Botai , Fu Yujie , Wang Hui , Jin Haojie , Ye Qing , Zhao Xiaojing , Jiang Liyan , Qin Wenxin
Published: March 2020

Background

Biological role and clinical significance of circular RNAs (circRNAs) remain largely unknown. Herein, we aimed to investigate biological function, molecular mechanism, and clinical significance of a circular RNA FOXM1 (circFOXM1) in non-small cell lung cancer (NSCLC).

Methods

Expression of circFOXM1 was measured in 48 paired samples of NSCLC by qRT-PCR. Functional roles of circFOXM1 on tumor cells were explored by in vitro and in vivo assays. Transcriptome sequencing was employed to screen the molecules involved in circFOXM1 regulatory network. RNA immunoprecipitation, luciferase analysis, RNA pull-down, and rescue assay were used to investigate potential mechanisms of circFOXM1.

Results

We found that circFOXM1 was significantly upregulated in NSCLC tissues, and its upregulation was positively correlated with advanced clinical stage and poor prognosis of NSCLC patients. Gain or loss-of-function assay showed that circFOXM1 promoted cell proliferation and cell cycle progression. In vivo assays showed that silencing circFOXM1 inhibited xenograft tumor growth. Mechanically, transcriptome sequencing data indicated that silencing circFOXM1 led to the downregulation of cell cycle-related mRNAs. RNA pull-down and dual-luciferase reporter assay suggested that circFOXM1 could bind to miR-614, and FAM83D was an essential gene involved in the circFOXM1/miR-614 regulatory network.

Conclusions

circFOXM1promotes NSCLC progression by interacting with miR-614 and thus inactivating the function of miR-614, which will further release the suppression of FAM83D. circFOXM1/miR-614/FAM83D regulatory network may serve as a potential therapeutic target for NSCLC patients.
Avocado: a multi-scale deep tensor factorization method learns a latent representation of the human epigenome
Authors: Schreiber Jacob , Durham Timothy , Bilmes Jeffrey , Noble William Stafford
Published: March 2020

The human epigenome has been experimentally characterized by thousands of measurements for every basepair in the human genome. We propose a deep neural network tensor factorization method, Avocado, that compresses this epigenomic data into a dense, information-rich representation. We use this learned representation to impute epigenomic data more accurately than previous methods, and we show that machine learning models that exploit this representation outperform those trained directly on epigenomic data on a variety of genomics tasks. These tasks include predicting gene expression, promoter-enhancer interactions, replication timing, and an element of 3D chromatin architecture.
Correction to: Effectiveness and pulmonary complications of perioperative laryngeal mask airway used in elderly patients (POLMA-EP trial): study protocol for a randomized controlled trial
Authors: Zhu Ling , Shi Xiao , Yin Suqing , Yin Jiemin , Zhu Ziyu , Gao Xiong , Jiao Yingfu , Yu Weifeng , Yang Liqun
Published: March 2020

After publication of our article [1] we have been notified on a mistake in the sample size.
The design and development of a multicentric protocol to investigate the impact of adjunctive doxycycline on the management of peripheral lymphoedema caused by lymphatic filariasis and podoconiosis
Authors: Horton John , Klarmann-Schulz Ute , Stephens Mariana , Budge Philip J. , Coulibaly Yaya , Debrah Alex , Debrah Linda Batsa , Krishnasastry Suma , Mwingira Upendo , Ngenya Abdallah , Wanji Samuel , Weerasooriya Mirani , Yahathugoda Channa , Kroidl Inge , Deathe Drew , Majewski Andrew , Sullivan Sarah , Mackenzie Charles , Nutman Thomas B. , Shott Joseph P. , Weil Gary , Ottesen Eric , Hoerauf Achim
Published: March 2020

Background

As new lymphatic filariasis infections are eliminated through mass chemotherapy, previously affected individuals are left with the sequellae, especially chronic progressive lymphoedema. Currently this is managed by careful attention to limb hygiene to prevent infection. Studies over the past 15 years have suggested that the incorporation of doxycycline treatment may arrest or even reverse progression of lymphoedema. Most of this work has been observational or based on small studies, and if this intervention is effective, studies need to be conducted on a larger scale and under diverse geographical and social conditions before it can be incorporated into treatment policy.

Methods/Design

The double-blind, placebo-controlled study was designed to investigate the impact of six weeks treatment with doxycycline added to standard limb hygiene on early stage filarial lymphoedema in five sites in Africa and the Indian subcontinent. One site in Cameroon is selected for studying lymphoedema in podoconiosis. Each site was individually powered with the potential to undertake a meta-analysis on completion. Evaluation methods followed those used in Ghana in 2012 with additions resulting from advances in technology. The details of the core protocol and how it was varied to take account of differing situations at each of the sites are provided. The study will enrol up to 1800 patients and will complete in mid-2021.

Conclusions

This paper provides details of what challenges were faced during its development and discusses the issues and how they were resolved. In particular, the reasons for inclusion of new technology and the problems encountered with the supply of drugs for the studies are described in detail. By making these details available, it is hoped that the study protocol will help others interested in improving treatment for filarial lymphoedema in the design of future studies.

Trial registration India: Clintrials.gov. NCT02929121 registered 10 Oct 2016: https://clinicaltrials.gov/ct2/show/NCT02929121

Mali: Clintrials.gov. NCT02927496 registered 7 Oct 2016: https://clinicaltrials.gov/ct2/show/NCT0292749

Sri Lanka: Clintrials.gov. NCT02929134 registered 10 Oct 2016: https://clinicaltrials.gov/ct2/show/NCT02929134

Ghana: ISRCTN. 14042737 registered 10 July 2017: 10.1186/ISRCTN14042737

Tanzania: ISRCTN. 65756724 registered 21 July 2017: 10.1186/ISRCTN65756724

Cameroon: ISRCTN. 1181662 registered 25 July 2017: 10.1186/ISRCTN11881662
Male involvement in prevention of mother to child transmission of human immuno virus and associated factors among partners’ of reproductive age women at Debre Tabor town, Northwest Ethiopia: a community based cross sectional study
Authors: Dagnew Enyew , Andualem Miteku , Worku Temesegen , Gebeyehu Dawit , Taklual Wubet , Melkie Abenezer
Published: March 2020

Objective

The aim of this study was to determine the prevalence of male involvement in prevention of mother to child transmission (PMTCT) of human immune virus (HIV) and associated factors among partners’ of reproductive age women at Debre Tabor town, Northwest Ethiopia. A community based cross sectional study was employed among 561 study participants. Data was collected with pretested structured questionnaire. The data was entered by Epi-Info version 7 software and exported to SPSS version 23 for analysis. Statistical significance was declared at P value of < 0.05.

Results

In this study, only 119 (21.2%) of males (95% CI 17.8%, 24.8%) were involved in PMTCT of HIV. Being government employee (AOR = 3.73, 95%CI (2.169, 6.419)), had ever heard about PMTCT of HIV (AOR = 2.46, 95%CI (1.20, 5.02)), discussed with their partner (AOR = 3.11, 95%CI (1.43, 6.55)), partners’ who were informed the need to go PMTCT of HIV clinic (AOR = 2.45, 95%CI (1.17, 5.14)), Health workers friendly approach (AOR = 2.36, 95%CI (1.34, 4.15)), and long waiting time (AOR = 0.36, 95%CI (0.216, 0.610)) were found to be significantly associated with male involvement in PMTCT of HIV. Improving service provision including respectful care and health education on PMTCT of HIV for males and their partners shall be emphasized by the government.
Rotavirus and Cryptosporidium pathogens as etiological proxies of gastroenteritis in some pastoral communities of the Amathole District Municipality, Eastern Cape, South Africa
Authors: Msolo Luyanda , Iweriebor Benson C. , Okoh Anthony I.
Published: March 2020

Objective

Cryptosporidium and Rotavirus agents have been associated with severe diarrheal illnesses and remain as one of the worst human health burdens in most developing regions. In the present study, we evaluated the incidences of Cryptosporidium and Rotavirus in diarrheal stool specimens of patients in some rural settlements of the Amathole District Municipality in the Eastern Cape Province, South Africa. Stool specimens from diarrheal children and elderly individuals were collected from clinics and hospitals within the rural communities of the region over a period of 21 months (February 2017–November 2018). Commercial enzyme-immuno-assays were used for the detection of Rotavirus and Cryptosporidium pathogens from processed diarrheal stool specimens.

Results

A total of 53 fresh stool samples from diarrheal patients were screened and 36% of the diarrheagenic stool specimens tested positive for Group A Rotavirus antigens, while 5.7% tested positive for Cryptosporidium antigens. Our findings reveal Rotavirus and Cryptosporidium pathogens as important etiological agents associated with diarrheal illnesses in children, among the rural hinterlands of the Amathole District Municipality.
Association between dietary energy density with mental health and sleep quality in women with overweight/obesity
Authors: Maddahi Niloofar Sadat , Yarizadeh Habib , Setayesh Leila , Nasir Yasaman , Alizadeh Shahab , Mirzaei Khadijeh
Published: March 2020

Objective

Mental health, sleep quality, and dietary intake are interlinked. Impairment of mental health and low sleep quality may contribute to obesity through the consumption of diets high in energy density. Nevertheless, it is not clear whether dietary energy density (DED) influences mental health. This study aimed to examine the association of DED with mental health indices, including depression, anxiety, stress, and sleep quality in women with overweight/obesity.

Results

There was a decreasing trajectory in serum triglyceride across quartiles of DED (from Q1 to Q4) in the crude analysis and also after adjustment for age, BMI, and physical activity After adjustment for age, BMI, and physical activity, subjects in the highest quartile of DED had higher systolic and diastolic blood pressure. DED was significantly associated with increased odds of stress in the crude (OR = 2.15, 95% CI 1.01–4.56, p = 0.04) and adjusted model for age, BMI, and physical activity (OR = 2.56, 95% CI 1.13–5.79, p = 0.02). No significant relationship was observed between DED and depression, anxiety and sleep quality. In conclusion, current study shows preliminary evidence of an association between DED and stress.
Women in focus: advice from the front lines on how to enable well-being and build resilience
Authors: Morris Elizabeth , Kubik-Huch Rahel A. , Abdel-Wahab May , Balogun Elizabeth , Beardmore Charlotte , Beets-Tan Regina , Boyd-Thorpe Aidan , Derchi Lorenzo , Fuchsjäger Michael , Husband Janet , Jackson Valerie , Salama Dina Husseiny , Vilgrain Valérie , Hricak Hedvig
Published: March 2020

The 2019 European Congress of Radiology program, “Women in Focus: Be Inspired,” offered insights from successful women and men for overcoming a number of everyday work and personal life challenges. With regard to balancing career and personal life and achieving well-being, the advice of female and male radiology leaders on the front lines, throughout the world, shares common themes. This paper highlights and expands on points of advice and encouragement from the “Women in Focus” program. The first step is to know yourself, so you can set priorities. Then, take charge, be brave, and follow your dreams, which may not be the same as other people’s. Finding balance requires examining your goals and acknowledging that you may not be able to get everything you want all at once. Receiving effective mentorship from numerous sources is key, as is finding an environment that supports your growth. It is important to surround yourself both at work and at home with people who support your ideas and give you a sense of peace, well-being, and resilience. If the culture does not fit, have the courage to move on. Current leaders should reach out to ensure the diversity of future teams. Society benefits, radiology benefits, and our patients benefit from a specialty that values equity, diversity, and inclusiveness.
Harmonisation of imaging dosimetry in clinical practice: practical approaches and guidance from the ESR EuroSafe Imaging initiative
Authors:   on behalf of the European Society of Radiology (ESR), Vano Eliseo , Frija Guy , Stiller Wolfram , Efstathopoulos Efstathios , Granata Claudio , Loose Reinhard , Paulo Graciano , Pekarovic Dean , Sjöberg Johan , Donoso-Bach Lluís
Published: March 2020

The European Directive 2013/59/EURATOM requires member states of the European Union to ensure justification and optimisation of the radiological procedures and to include information on patient exposure as part of the report of the examinations. The EuroSafe Imaging campaign of the European Society of Radiology created a working group (WG) on “Dosimetry for imaging in clinical practice” with the aim to help with the dosimetry aspects required by European and national regulations. The primary focus topics were selected and a survey among the experts of the WG, allowed suggesting some initial consensus approaches.

For information on patient exposure, it was agreed to include the dosimetric values reported by the imaging modalities (validated by a medical physics expert). It was also suggested to prepare educational material on dosimetric quantities for patients. Individual optimisation was considered a challenge, especially for interventional procedures. In these cases, patient and occupational doses should be part of the global optimisation process and trigger levels should be defined to avoid skin radiation injuries. Diagnostic Reference Levels (DRLs) always need to be considered for comparison with periodic patient dose audits. In the case of accidental or unintended exposures, a report should be produced for the Quality Assurance programme, together with an educational note to avoid the repetition of incidents. Dose registry and management systems should allow fulfilling the regulatory requirements of national and European regulations. In a second step, and after the initial experience with the Directive implementation, a wider survey will be considered.
Comparison and improvement of the predictability and interpretability with ensemble learning models in QSPR applications
Authors: Chen Chia-Hsiu , Tanaka Kenichi , Kotera Masaaki , Funatsu Kimito
Published: March 2020

Ensemble learning helps improve machine learning results by combining several models and allows the production of better predictive performance compared to a single model. It also benefits and accelerates the researches in quantitative structure–activity relationship (QSAR) and quantitative structure–property relationship (QSPR). With the growing number of ensemble learning models such as random forest, the effectiveness of QSAR/QSPR will be limited by the machine’s inability to interpret the predictions to researchers. In fact, many implementations of ensemble learning models are able to quantify the overall magnitude of each feature. For example, feature importance allows us to assess the relative importance of features and to interpret the predictions. However, different ensemble learning methods or implementations may lead to different feature selections for interpretation. In this paper, we compared the predictability and interpretability of four typical well-established ensemble learning models (Random forest, extreme randomized trees, adaptive boosting and gradient boosting) for regression and binary classification modeling tasks. Then, the blending methods were built by summarizing four different ensemble learning methods. The blending method led to better performance and a unification interpretation by summarizing individual predictions from different learning models. The important features of two case studies which gave us some valuable information to compound properties were discussed in detail in this report. QSPR modeling with interpretable machine learning techniques can move the chemical design forward to work more efficiently, confirm hypothesis and establish knowledge for better results.
Phase-dependence of response curves to deep brain stimulation and their relationship: from essential tremor patient data to a Wilson–Cowan model
Authors: Duchet Benoit , Weerasinghe Gihan , Cagnan Hayriye , Brown Peter , Bick Christian , Bogacz Rafal
Published: March 2020

Essential tremor manifests predominantly as a tremor of the upper limbs. One therapy option is high-frequency deep brain stimulation, which continuously delivers electrical stimulation to the ventral intermediate nucleus of the thalamus at about 130 Hz. Constant stimulation can lead to side effects, it is therefore desirable to find ways to stimulate less while maintaining clinical efficacy. One strategy, phase-locked deep brain stimulation, consists of stimulating according to the phase of the tremor. To advance methods to optimise deep brain stimulation while providing insights into tremor circuits, we ask the question: can the effects of phase-locked stimulation be accounted for by a canonical Wilson–Cowan model? We first analyse patient data, and identify in half of the datasets significant dependence of the effects of stimulation on the phase at which stimulation is provided. The full nonlinear Wilson–Cowan model is fitted to datasets identified as statistically significant, and we show that in each case the model can fit to the dynamics of patient tremor as well as to the phase response curve. The vast majority of top fits are stable foci. The model provides satisfactory prediction of how patient tremor will react to phase-locked stimulation by predicting patient amplitude response curves although they were not explicitly fitted. We also approximate response curves of the significant datasets by providing analytical results for the linearisation of a stable focus model, a simplification of the Wilson–Cowan model in the stable focus regime. We report that the nonlinear Wilson–Cowan model is able to describe response to stimulation more precisely than the linearisation.
Maternal and fetal thyroid dysfunction following porcine reproductive and respiratory syndrome virus2 infection
Authors: Pasternak J. Alex , MacPhee Daniel J. , Harding John C. S.
Published: March 2020

To better understand the host response to porcine reproductive and respiratory virus-2 (PRRSV2) we evaluated circulating thyroid hormone and associated gene expression in a late gestation challenge model. Pregnant gilts were inoculated at gestation day 85 and fetal samples collected at either 12 or 21 days post-infection (dpi). A subset of fetuses was selected for analysis based on viability and viral load categorized as either uninfected-viable (UNIF), high viral load viable (HV-VIA) or high viral load meconium stained (HV-MEC) and were compared with gestational age matched controls (CON). In dams, circulating levels of total T3 and T4 decreased in the acute period following infection and rebounded by 21 dpi. A similar effect was observed in fetuses, but was largely restricted to HV-VIA and HV-MEC, with minimal decrease noted in UNIF relative to CON at 21 dpi. Gene expression in fetal heart at 12 dpi showed significant decompensatory transcription of thyroid hormone transporters (SLC16A2) and deiodinases (DIO2, DIO3), which was not observed in brain. Correspondingly, genes associated with cell cycle progression (CDK1,2,4) were downregulated in only the heart of highly infected fetuses, while expression of their inhibitor (CDKN1A) was upregulated in both tissues. Finally, expression of genes associated with cardiac stress including CAMKD and AGT were upregulated in the hearts of highly infected fetuses, and a shift in expression of MYH6 to MYH7 was observed in HV-MEC fetuses specifically. Collectively, the results suggest PRRSV2 infection causes a hypothyroid state that disproportionally impacts the fetal heart over the brain.
Sphingolipids are required for exocyst polarity and exocytic secretion in Saccharomyces cerevisiae
Authors: Guo Qingguo , Zhang Tianrui , Meng Na , Duan Yuran , Meng Yuan , Sun Dong , Liu Ying , Luo Guangzuo
Published: March 2020

Background

Exocytosis is a process by which vesicles are transported to and fused with specific areas of the plasma membrane. Although several studies have shown that sphingolipids are the main components of exocytic compartments, whether they control exocytosis process is unclear.

Results

Here, we have investigated the role of sphingolipids in exocytosis by reducing the activity of the serine palmitoyl-transferase (SPT), which catalyzes the first step in sphingolipid synthesis in endoplasmic reticulum. We found that the exocyst polarity and exocytic secretion were impaired inlcb1-100mutant cells and in wild type cells treated with myriocin, a chemical which can specifically inhibit SPT enzyme activity, suggesting that sphingolipids controls exocytic secretion. This speculation was further confirmed by immuno-fluorescence and electron microscopy results that small secretory vesicles were accumulated inlcb1-100mutant cells.

Conclusions

Taken together, our results suggest that sphingolipids are required for exocytosis. Mammals may use similar regulatory mechanisms because components of the exocytic secretion apparatus and signaling pathways are conserved.
Low intake of iodized salt and iodine containing supplements among pregnant women with apparently insufficient iodine status - time to change policy?
Authors: Rosen Shani R. , Ovadia Yaniv S. , Anteby Eyal Y. , Fytlovich Shlomo , Aharoni Dorit , Zamir Doron , Gefel Dov , Shenhav Simon
Published: March 2020

Background

Iodine is an essential nutrient for human health throughout the life cycle, especially during early stages of intrauterine life and infancy, to ensure adequate neurocognitive development. The growing global reliance on desalinated iodine-diluted water raises the specter of increased iodine deficiency in several regions. The case of Israel may be instructive for exploring the link between iodine status and habitual iodine intake in the setting of extensive national reliance on desalinated water. The aim of this study was to explore the relationship between iodine intake, including iodized salt and iodine-containing supplements intake, and iodine status among pregnant women residing in a sub-district of Israel that is highly reliant on desalinated iodine-diluted water.

Methods

A total of 134 consecutive pregnant women were recruited on a voluntary basis from the obstetrics department of the Barzilai University Medical Center during 2018. Blood was drawn from participants to determine levels of serum thyrotropin (TSH), thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb) and thyroglobulin (Tg). An iodine food frequency questionnaire (sIFFQ) was used to assess iodine intake from food, IS and ICS. A questionnaire was used to collect data on demographic and health characteristics.

Results

A total of 105 pregnant women without known or reported thyroid disease were included in the study. Elevated Tg values (≥ 13 μg/L), were found among 67% of participants, indicating insufficient iodine status. The estimated iodine intake (median, mean ± SD 189, 187 ± 106 μg/d by sIFFQ) was lower than the levels recommended by the World Health Organization and the Institute of Medicine (250 vs. 220 μg/day respectively). The prevalence of iodized salt intake and iodine containing supplement intake were 4 and 52% (respectively). Values of Tg > 13 μg/L were inversely associated with compliance with World Health Organization and Institute of Medicine recommendations.

Conclusions

While the Israeli Ministry of Health has recommended the intake of iodized salt and iodine containing supplements, this is apparently insufficient for achieving optimal iodine status among Israeli pregnant women. The evidence of highly prevalent probable iodine deficiency in a sample of pregnant women suggests an urgent need for a national policy of iodized salt regulation, as well as guidelines to promote iodine containing supplements and adherence to them by caregivers. In addition, studies similar to this one should be undertaken in additional countries reliant on desalinated iodine-diluted water to further assess the impact of desalinization on maternal iodine status.
Lyapunov-type inequalities for higher-order half-linear difference equations
Authors: Liu Haidong
Published: March 2020

In this paper, we will establish some new Lyapunov-type inequalities for some higher-order superlinear–sublinear difference equations with boundary conditions. Our results not only complement the existing results established in the literature, but also furnish a handy tool for the study of qualitative properties of solutions of some difference equations.
An ADMM-based SQP method for separably smooth nonconvex optimization
Authors: Liu Meixing , Jian Jinbao
Published: March 2020

This work is about a splitting approach for solving separably smooth nonconvex linearly constrained optimization problems. Based on the ideas from two classical methods, namely the sequential quadratic programming (SQP) and the alternating direction method of multipliers (ADMM), we propose an ADMM-based SQP method. We focus on decomposing the quadratic programming (QP) subproblem of the primal problem into small-scale QP subproblems, which further embedded with Bregman distances can be solved effectively and followed by a dual ascent type update for the Lagrangian multipliers. Under suitable conditions as well as the crucial Kurdyka–Łojasiewicz property, we establish the global and strong convergence properties of the proposed method.
On convex combinations of harmonic mappings
Authors: Beig Subzar , Sim Young Jae , Cho Nak Eun
Published: March 2020

Let$\psi_{\mu,\nu}(z)=(1-2\cos\nu e^{i\mu}z+e^{2i\mu}z^{2})^{-1}$ψμ,ν(z)=(1−2cosνeiμz+e2iμz2)−1,$\mu,\nu\in[0,2\pi)$μ,ν∈[0,2π)andpbe an analytic mapping with$\operatorname{Re} p>0$Rep>0on the open unit disk. We consider the sense-preserving planar harmonic mappings$f=h+\overline{g}$f=h+g‾, which are shears of the mapping$\int_{0}^{z} \psi_{\mu,\nu}(\xi) p(\xi)\,{d}\xi$∫0zψμ,ν(ξ)p(ξ)dξin the directionμ. These mappings include the harmonic right half-plan mappings, vertical strip mappings, and their rotations. For various choices of dilatations$g'/h'$g′/h′off, sufficient conditions are found for the convex combinations of these mappings to be univalent and convex in the directionμ.
What influences the selection of contextual cues when starting a new routine behaviour? An exploratory study
Authors: Stawarz Katarzyna , Gardner Benjamin , Cox Anna , Blandford Ann
Published: March 2020

Background

Contextual cues play an important role in facilitating behaviour change. They not only support memory but may also help to make the new behaviour automatic through the formation of new routines. However, previous research shows that when people start a new behaviour, they tend to select cues that lack effectiveness for prompting behaviour. Therefore, it is important to understand what influences cue selection, as this can help to identify acceptable cues, which in turn could inform future behaviour change interventions to help people select cues that best fit their context and so ensure continued repetition.

Methods

We conducted a qualitative study to investigate what cues people select, how, and what influences their decisions. We recruited 39 participants and asked them to take vitamin C tablets daily for 3 weeks and later interviewed them about their experience. Quantitative habit strength and memory measures were taken for descriptive purposes.

Results

Cue selection was primarily influenced by a desire to minimise effort, e.g. keeping related objects at hand or in a visible place; prior experience with similar behaviours (regardless of whether the cues used in the past were reliable or not); and beliefs about effective approaches. In addition, we found that suboptimal remembering strategies involved reliance on a single cue and loosely defined plans that do not specify cues. Moreover, for many participants, identifying optimal cues required trial and error, as people were rarely able to anticipate in advance what approach would work best for them.

Conclusions

Future behaviour change interventions that rely on routine behaviours might fruitfully include the provision of educational information regarding what approaches are suboptimal (single factors, vaguely defined plans) and what is most likely to work (combining multiple clearly defined cues). They should also assess people’s existing beliefs about how to best remember specific behaviours as such beliefs can either enhance or inhibit the cues they select. Finally, interventions should account for the fact that early failures to remember are part of the process of developing a reliable remembering strategy and to be expected.
Enhancing response time thresholds with response behaviors for detecting disengaged examinees
Authors: Sahin Füsun , Colvin Kimberly F.
Published: March 2020

The item responses of examinees who rapid-guess, who do not spend enough time reading and engaging with an item, will not reflect their true ability on that item. Rapid-disengagement refers to rapidly selecting a response to multiple-choice items (i.e., rapid-guess), omitting items, or providing short-unrelated answers to open-ended items in an unreasonably short time. Such rapid responses need to be identified to enhance the validity of the arguments from the test data. Detection of rapid-guessing behaviors is typically based on identifying a threshold to represent the minimum response time required for the student to have thoughtfully considered a given item. This study investigates whether using response behaviors can improve the detection of rapid-disengagement by investigating two approaches: (a) using response behaviors to decide on the size of the threshold, and (b) using response behaviors as a condition for detecting disengaged examinees in addition to response times, referred as enhanced methods. Process data and item responses from the PISA 2012 computer-based mathematics assessment were used to examine both approaches under threshold values varying from very small (5 s) to very large (60 s). Results suggested that response behaviors can provide meaningful input on establishing the size of the threshold and that while enhanced methods performed better than using only response times in recognizing rapid-disengagement in some cases, no clear pattern was observed as to when such improvement occurs. This study makes a unique contribution by inspecting the response behaviors of disengaged examinees and providing guidelines on using response behaviors to decide on the size of the threshold. This study suggests response behavior categories that can be applicable to many item and response types, which make them suitable for use in digitally-based large-scale assessments.
Understanding and reconstructing the coastal sea level variations along the western boundary of the North Pacific
Authors: Li Penghui , Xu Fanghua
Published: March 2020

To better understand the coastal sea level (SL) variations along the western boundary of the North Pacific, we quantitatively estimate the contributions of various forcing to the coastal SL variations on seasonal and longer time scales. Based on a western boundary SL theory and a linear least-squares regression, we obtain a polynomial equation to estimate the coastal SL variations from ocean interior information, atmospheric forcing, as well as local steric effects. The estimated results can explain about 91% (93%) of the SL variations at tide gauges south (north) of the Kuroshio extension jet. It is found that the local thermosteric effect is dominant on seasonal time scales. On interannual time scales, the signals from ocean interior and atmospheric forcing are dominant. For decadal SL trends, the coastal SL rise is mainly resulted from the signals from the open ocean. With the same polynomial equation, the SL variations at 6 new tide gauges were estimated and compared to the nearest satellite measurements. The newly estimated SL is generally in much better agreement with the tide gauge data than the satellite data. It is promising to apply the newly derived polynomial equation to estimate SL variations along the western boundary of the North Pacific where tide gauge data are not available. Particularly, the approach is promising to estimate the future SL change given the required oceanic and atmospheric conditions.
Sagittal instability with inversion is important to evaluate after syndesmosis injury and repair: a cadaveric robotic study
Authors: Patel Neel K. , Murphy Conor I. , Pfeiffer Thomas R. , Naendrup Jan-Hendrik , Zlotnicki Jason P. , Debski Richard E. , Hogan MaCalus V. , Musahl Volker
Published: March 2020

Purpose

Disruption of the syndesmosis, the anterior-inferior tibiofibular ligament (AITFL), the posterior-inferior tibiofibular ligament (PITFL), and the interosseous membrane (IOM), leads to residual symptoms after an ankle injury. The objective of this study was to quantify tibiofibular joint motion with isolated AITFL- and complete syndesmotic injury and with syndesmotic screw vs. suture button repair compared to the intact ankle.

Methods

Nine fresh-frozen human cadaveric specimens (mean age 60 yrs.; range 38–73 yrs.) were tested using a six degree-of-freedom robotic testing system and three-dimensional tibiofibular motion was quantified using an optical tracking system. A 5 Nm inversion moment was applied to the ankle at 0°, 15°, and 30° plantarflexion, and 10° dorsiflexion. Outcome measures included fibular medial-lateral translation, anterior-posterior translation, and external rotation in each ankle state: 1) intact ankle, 2) AITFL transected (isolated AITFL injury), 3) AITFL, PITFL, and IOM transected (complete injury), 4) tricortical screw fixation, and 5) suture button repair.

Results

Both isolated AITFL and complete injury caused significant increases in fibular posterior translation at 15° and 30° plantarflexion compared to the intact ankle (p < 0.05). Tricortical screw fixation restored the intact ankle tibiofibular kinematics in all planes. Suture button repair resulted in 3.7 mm, 3.8 mm, and 2.9 mm more posterior translation of the fibula compared to the intact ankle at 30° and 15° plantarflexion and 0° flexion, respectively (p < 0.05).

Conclusion

Ankle instability is similar after both isolated AITFL and complete syndesmosis injury and persists after suture button fixation in the sagittal plane in response an inversion stress. Sagittal instability with ankle inversion should be considered when treating patients with isolated AITFL syndesmosis injuries and after suture button fixation.

Level of evidence

Controlled laboratory study, Level V.
Geometric conditions of a two-link-and-six muscle structure based on internal force stability
Authors: Ochi Hiroaki , Kino Hitoshi , Tahara Kenji , Matsutani Yuki
Published: March 2020

In a musculoskeletal system, internal tensile forces are generated among the muscles because it is a redundant system. The balancing of the internal tensile forces for a given posture generates a potential field in the system. Therefore, the potential field is utilized for the sensorless feedforward position control and improvement of stability based on the feedback method. However, the stability of the internal tensile forces is strongly influenced by the muscular arrangement. Previous studies showed that a stable condition can be identified through the minimization of the potential at a desired posture, and the sufficient condition has been theoretically established; however, the geometric condition of the muscular arrangement has not been determined. To effectively exploit the characteristics of the internal tensile forces, the geometric condition must be elucidated in the design of a musculoskeletal system. This paper aims to clarify the geometric condition to generate stable internal tensile forces. Based on the conditions generating the potential that is minimum at the desired posture, the paper analyzes that the geometric condition on a musculoskeletal structure with two-link and six-muscle. Additionally, the identified condition is assessed based on simulations. As a result, we revealed the geometric condition of the muscular arrangement to generate stable internal tensile forces. By designing the muscular arrangement to satisfy the condition, the stability of the internal tensile forces is ensured, and consequently, a control method utilizing the characteristics of the internal tensile force is stably implemented.
Using FFPE RNA-Seq with 12 marker genes to evaluate genotoxic and non-genotoxic rat hepatocarcinogens
Authors: Furihata Chie , You Xinyue , Toyoda Takeshi , Ogawa Kumiko , Suzuki Takayoshi
Published: March 2020

Introduction

Various challenges have been overcome with regard to applying ‘omics technologies for chemical risk assessments. Previously we published results detailing targeted mRNA sequencing (RNA-Seq) on a next generation sequencer using intact RNA derived from freshly frozen rat liver tissues. We successfully discriminated genotoxic hepatocarcinogens (GTHCs) from non-genotoxic hepatocarcinogens (NGTHCs) using 11 selected marker genes. Based on this, we next attempted to use formalin-fixed paraffin-embedded (FFPE) pathology specimens for RNA-Seq analyses.

Findings

In this study we performed FFPE RNA-Seq to compare a typical GTHC, 2-acetylaminofluorene (AAF) to genotoxicity equivocal p-cresidine (CRE). CRE is used as a synthetic chemical intermediate, and this compound is classified as an IARC 2B carcinogen and is mutagenic in S. typhimurium, which is non-genotoxic to rat livers as assessed by single strand DNA damage analysis. RNA-Seq was used to examine liver FFPE samples obtained from groups of five 10-week-old male F344 rats that were fed with chemicals (AAF: 0.025% and CRE: 1% in food) for 4 weeks or from controls that were fed a basal diet. We extracted RNAs from FFPE samples and RNA-Seq was performed on a MiniSeq (Illumina) using the TruSeq custom RNA panel. AAF induced remarkable differences in the expression of eight genes (Aen, Bax, Btg2, Ccng1, Gdf15, Mbd1, Phlda3 and Tubb4b) from that in the control group, while CRE only induced expression changes in Gdf15, as shown using Tukey’s test. Gene expression profiles for nine genes (Aen, Bax, Btg2, Ccng1, Cdkn1a, Gdf15, Mbd1, Phlda3, and Plk2) differed.

between samples treated with AAF and CRE. Finally, principal component analysis (PCA) of 12 genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15, Lrp1, Mbd1, Phlda3, Plk2, and Tubb4b) using our previous Open TG-GATE data plus FFPE-AAF and FFPE-CRE successfully differentiated FFPE-AAF, as GTHC, from FFPE-CRE, as NGHTC.

Conclusion

Our results suggest that FFPE RNA-Seq and PCA are useful for evaluating typical rat GTHCs and NGTHCs.
A review of the manufacturing process and infection rate of 3D-printed models and guides sterilized by hydrogen peroxide plasma and utilized intra-operatively
Authors: Shea Graham Ka-Hon , Wu Kenneth Lap-Kei , Li Iris Wai-Sum , Leung Man-Fai , Ko Ada Lai-Ping , Tse Lane , Pang Sherby Suet-Ying , Kwan Kenny Yat-Hong , Wong Tak-Man , Leung Frankie Ka-Li , Fang Christian Xinshuo
Published: March 2020

3D printing in the context of medical application can allow for visualization of patient-specific anatomy to facilitate surgical planning and execution. Intra-operative usage of models and guides allows for real time feedback but ensuring sterility is essential to prevent infection. The additive manufacturing process restricts options for sterilisation owing to temperature sensitivity of thermoplastics utilised for fabrication. Here, we review one of the largest single cohorts of 3D models and guides constructed from Acrylonitrile butadiene styrene (ABS) and utilized intra-operatively, following terminal sterilization with hydrogen peroxide plasma. We describe our work flow from initial software rendering to printing, sterilization, and on-table application with the objective of demonstrating that our process is safe and can be implemented elsewhere. Overall, 7% (8/114 patients) of patients developed a surgical site infection, which was not elevated in comparison to related studies utilizing traditional surgical methods. Prolonged operation time with an associated increase in surgical complexity was identified to be a risk factor for infection. Low temperature plasma-based sterilization depends upon sufficient permeation and contact with surfaces which are a particular challenge when our 3D-printouts contain diffusion-restricted luminal spaces as well as hollows. Application of printouts as guides for power tools may further expose these regions to sterile bodily tissues and result in generation of debris. With each printout being a bespoke medical device, it is important that the multidisciplinary team involved in production and application understand potential pitfalls to ensuring sterility as to minimize infection risk.
Integrins in multiple myeloma
Authors: Hosen Naoki
Published: March 2020

Integrins have crucial roles in BM homing, survival, proliferation, or drug resistance of multiple myeloma (MM) cells. Especially, integrin α4β1 (VLA-4) and α4β7 has been reported to have important functions in MM cells, and therefore are potential therapeutic targets. We have recently shown that integrin β7 constitutively adopts the active conformation specifically in MM cells, and found that chimeric antigen receptor (CAR) T cells targeting the activated conformation of integrin β7 is promising for MM. Although the mechanism for the constitutive activation is still being investigated, our results indicate that integrin conformation is different between MM and normal cells and suggest that it may be associated with the pathology of MM.
Role of self-focussed reappraisal of negative emotion in emergence of emotional symptoms in adolescent girls
Authors: Malhi Gin S. , Das Pritha , Outhred Tim , Bryant Richard A. , Calhoun Vince
Published: March 2020

Background

Adolescent subthreshold emotional symptoms arise from impaired self-referential information-processing and approach–avoidance behaviour network integration, which compromises goal evaluation and pursuit strategies.

Aims

We investigated whether impairment of negative emotion (goal) reappraisal strategies (self-focussing and self-distancing) generates emotional symptoms (emotional disorders precursors).

Method

Using functional magnetic resonance imaging and a triple-network model (default mode, executive control and salience), functional connectivity differences within and between networks, and their modulation by task and relationships with emotional symptoms were determined in healthy adolescent girls (N = 202) grouped by presence or absence of emotional symptoms.

Results

The groups differed in spectral power distribution and in dorsal default mode network and right executive control network modulation when self-focussing and self-distancing, respectively. Girls without emotional symptoms had greater spectral power and less network modulation. Greater spectral power was associated with reduced emotional symptoms and less dorsal default mode network modulation when self-focussing.

Conclusions

The early phases of anxiety and depressive disorders in adolescence are marked by emotional symptoms that usually emerge in the context of negative life events. To contend with the negative effect of such events, a typical reappraisal strategy is to distance oneself and switch the focus of one's thinking. This brain-imaging study in adolescent girls prone to the development of emotional disorders has found functional changes in key neural networks that are involved in reappraisal and shown that this process is impaired. This is important because it provides an early indication of these common disorders and a potential target for psychological interventions.