bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of the socioeconomic factor on Parkinson's disease medication adherence: a scoping review
Authors: Gil Gustavo , Tosin Michelle H. S. , Ferraz Henrique Ballalai
Published: February 2024

Background Therapeutic adherence is a decisive issue on chronic disease management in patients requiring long-term pharmacotherapy, such as Parkinson's disease (PD). Although it is well known that socioeconomic factor is a barrier to medication adherence in many chronic diseases, its impacts on PD still need to be investigated.

Objective Explore what and how socioeconomic factors impact medication adherence in people with PD.

Methods We carried out a scoping review across three databases to identify studies exploring what and how socioeconomic factors impact medication adherence in people with PD considering eight attributes: 1. educational level, 2. disease-related knowledge, 3. income, 4. cost of medication, 5. drug subsidy (meaning presence of subsidies in the cost of medication), 6. employability, and 7. ethnicity (black, indigenous, immigrants).

Results Of the 399 identified studies (Embase = 294, Medline = 88, LILACS = 17), eight met inclusion criteria. We identified factors covering the eight attributes of socioeconomic impact, and all of them negatively impacted the medication adherence of people with PD. The most prevalent factor in the studies was low patient educational level (four studies), followed by costs of medications (three studies), income (three studies), and disease-related knowledge (three studies). Distinctly from most of the studies selected, one of them evidenced suboptimal adherence in individuals receiving the medication free of charge, and another one could not find correlation between suboptimal adherence and educational level.

Conclusion Socioeconomic factors negatively impact medication adherence in PD patients. This review provides basis for developing patient and population-based interventions to improve adherence to treatment in PD.
Risk Profiles and Treatment Patterns in Atrial Fibrillation Patients with Chronic Kidney Disease Receiving or not Receiving Anticoagulation Therapy
Authors: Kreutz Reinhold , Deray Gilbert , Floege Jürgen , Gwechenberger Marianne , Hahn Kai , Luft Andreas R. , Persson Pontus , Axthelm Christoph , Beer Juerg Hans , Bergler-Klein Jutta , Lellouche Nicolas , Taggeselle Jens , Beyer-Westendorf Jan
Published: February 2024

Background Patients with atrial fibrillation (AF) and chronic kidney disease (CKD) are at high risk for both thromboembolism and bleeding events. The latter induces a potential reason for withholding oral anticoagulation (OAC) despite an indication for prophylaxis of thromboembolic events.

Methods AF patients with CKD (estimated glomerular filtration [eGFR] rate between 15 and 49 mL/min per 1.73 m2) were included in a prospective international registry in Europe between 2016 and 2020, that is, XARENO (factor XA inhibition in renal patients with nonvalvular atrial fibrillation observational registry). The study enrolled adult patients treated at the discretion of physicians with rivaroxaban, vitamin K antagonists (VKA), or without OAC (w/oOAC). Here, we report a prespecified explorative baseline comparison between patients receiving OAC or no OAC within XARENO.

Results In total, 1,544 patients (mean age: 78.2 years, mean eGFR: 36.2 mL/min) were studied (rivaroxaban n = 764, VKA n = 691, w/oOAC n = 89). Patients in the w/oOAC group were older and had a similar stroke (mean CHA2DS2-VASc score 4.0) but higher bleeding risk (mean modified Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drugs/Alcohol Concomitantly score 2.5 vs. 1.8) compared with the OAC groups. The distribution of comorbidities including hypertension, diabetes, and heart failure was similar. Treatment with antiplatelet drugs was fivefold more frequent in the w/oOAC group.

Conclusion Only 5.8% of the overall population of AF patients with advanced CKD received no OAC. These patients were older and had a higher bleeding risk, which might explain this decision, but which contrasts with the more frequent use of antiplatelet drugs in this vulnerable group of patients.
Psychological needs and financial well-being: the role of consumer spending self-control
Authors: du Plessis Laureane , Jordaan Yolanda , van der Westhuizen Liezl-Marié
Published: February 2024

Financial service providers continually strive to develop innovative financial products and services that address customer needs and aim to improve customers’ financial well-being. Previous studies discovered that psychological need satisfaction is positively associated with psychological well-being and growth, while psychological need frustration is associated with problematic behaviour and ill-being. However, uncertainty still exists as to whether psychological needs are associated with financial well-being. Furthermore, whereas psychological need satisfaction is associated with positive day-to-day behaviours such as exhibiting self-control, psychological need frustration has been associated with irresponsible spending. Spending can be a psychological coping mechanism, and as such, the regulation of spending behaviour may aid financial well-being. Therefore, the main purpose of this article is to explore the relationship between psychological needs and financial well-being, and to assess whether consumer spending self-control can act as a regulating mechanism in this relationship. Data were collected by means of a self-administered questionnaire distributed via an online paid-for consumer panel to credit-active South African consumers. The results revealed that CSSC had a mediating effect on the relationships between psychological needs and financial well-being. This highlights the importance of developing and promoting consumer spending self-control as a strategy for financial well-being.
Quo vadis higher education? Post-pandemic success digital competencies of the higher educators – a Hungarian university case and actions
Authors: Jarjabka Ákos , Sipos Norbert , Kuráth Gabriella
Published: February 2024

The purpose of this paper is to show the necessary competence sets for Higher Education (HE) lecturers in the framework of the COVID and post-COVID. A COVID-situated competence survey was carried out among university lecturers. Exploratory and confirmatory factor analyses (EFA, CFA) were applied to show the significant digital education competence factors. The representative online survey of 322 respondents shows that three big competence sets can be identified: Awareness, Professional, and Digital. Those having higher scores in Professional competencies foresee more digital programs and communications in the future, and not only the digital competencies but also the professional ones should be developed to meet the requirements of the digital education transformation process. The findings emphasize that the forced and drastic changes in the application of digital education to the intensification of COVID-19 should become sustainable and find its proper place and role in the future HE. The structured and closely managed use of the results was followed by a set of digital and professional competence development initiatives carried out within the framework of the Digital Education and Learning Support Centre, founded in 2020 at the University of Pécs.
Identifying risks in temporal supernetworks: an IO-SuperPageRank algorithm
Authors: Liu Yijun , Jin Xiaokun , Zhang Yunrui
Published: February 2024

Complex systems pose risks characterized by factors such as uncertainty, nonlinearity, and diversity, making traditional risk measurement methods based on a probabilistic framework inadequate. Supernetworks can effectively model complex systems, and temporal supernetworks can capture the dynamic evolution of these systems. From the perspective of network stability, supernetworks can aid in risk identification for complex systems. In this paper, an IO-SuperPageRank algorithm is proposed based on the supernetwork topological structure. This algorithm reveals network instability by calculating changes in node importance, thereby helping to identify risks in complex systems. To validate the effectiveness of this algorithm, a four-layer supernetwork composed of scale-free networks is constructed. Simulated experiments are conducted to assess the impact of changes in intralayer edge numbers, intralayer node numbers, and interlayer superedge numbers on the risk indicator IO value. Linear regression and multiple tests were used to validate these relationships. The experiments show that changes in the three network topological indicators all bring about risks, with changes in intralayer node numbers having the most significant correlation with the risk indicator IO value. Compared to traditional measures of network node centrality and connectivity, this algorithm can more accurately predict the impact of node updates on network stability. Additionally, this paper collected trade data for crude oil, chemical light oil, man-made filaments and man-made staple fibers from the UN Comtrade Database. We constructed a man-made filaments and fibers supply chain temporal supernetwork, utilizing the algorithm to identify supply chain risks from December 2020 to October 2023. The study revealed that the algorithm effectively identified risks brought about by changes in international situations such as the Russia-Ukraine war, Israel–Hamas conflict, and the COVID-19 pandemic. This demonstrated the algorithm’s effectiveness in empirical analysis. In the future, we plan to further expand its application based on different scenarios, assess risks by analyzing changes in specific system elements, and implement effective risk intervention measures.
Modeling the link between tourism and economic development: evidence from homogeneous panels of countries
Authors: Cárdenas-García Pablo Juan , Brida Juan Gabriel , Segarra Verónica
Published: February 2024

Having previously analyzed the relationship between tourism and economic growth from distinct perspectives, this paper attempts to fill the void existing in scientific research on the relationship between tourism and economic development, by analyzing the relationship between these variables using a sample of 123 countries between 1995 and 2019. The Dumistrescu and Hurlin adaptation of the Granger causality test was used. This study takes a critical look at causal analysis with heterogeneous panels, given the substantial differences found between the results of the causal analysis with the complete panel as compared to the analysis of homogeneous country groups, in terms of their dynamics of tourism specialization and economic development. On the one hand, a one-way causal relationship exists from tourism to development in countries having low levels of tourism specialization and development. On the other hand, a one-way causal relationship exists by which development contributes to tourism in countries with high levels of development and tourism specialization.
Partially reflecting jamming objects in correlation-enhanced target detection with entangled photons
Authors: Kornienko V. V. , Vidal C. , Pönni A. , Raasakka M. , Tittonen I.
Published: February 2024

In the optical detection of distant objects, one can benefit from quantum light properties over those of classical light. Two-beam correlation-enhanced protocols can improve imaging or target detection even under strong background noise and in the low photon flux regime. We demonstrate that a partially reflecting jamming object introduces noise to these protocols, including quantum illumination. In contrast to background noise, the signal radiation reflected from the jammer is correlated with the corresponding idler beam. We analyze the means to mitigate this noise and introduce an indistinguishability parameter μ, showing how efficiently the jammer can be distinguished from the target. We use the quantum Chernoff bound and the density matrix orthogonalization procedure to separate the contributions from the target, the background, and the jammer. We illustrate our findings with an experiment using optical entangled photon pairs at 800 nm. Our results can be applied to the design of target detection protocols and advanced imaging techniques.
Programmable photonic system for quantum simulation in arbitrary topologies
Authors: Bartlett Ben , Long Olivia Y. , Dutt Avik , Fan Shanhui
Published: February 2024

Synthetic dimensions have generated great interest for studying many types of topological, quantum, and many-body physics, and they offer a flexible platform for simulation of interesting physical systems, especially in high dimensions. In this paper, we describe a programmable photonic device capable of emulating the dynamics of a broad class of Hamiltonians in lattices with arbitrary topologies and dimensions. We derive a correspondence between the physics of the device and the Hamiltonians of interest, and we simulate the physics of the device to observe a wide variety of physical phenomena, including chiral states in a Hall ladder, effective gauge potentials, and oscillations in high-dimensional lattices. Our proposed device opens new possibilities for studying topological and many-body physics in near-term experimental platforms.
Efficient ground state preparation in variational quantum eigensolver with symmetry-breaking layers
Authors: Park Chae-Yeun
Published: February 2024

A variational quantum eigensolver (VQE) solves the ground state problem of a given Hamiltonian by finding the parameters of a quantum circuit Ansatz that minimizes the Hamiltonian expectation value. Among possible quantum circuit Ansätze, the Hamiltonian variational Ansatz (HVA) is widely studied for quantum many-body problems as the Ansatz with sufficiently large depth is theoretically guaranteed to express the ground state. However, since the HVA shares the same symmetry with the Hamiltonian, it is not necessarily good at finding symmetry-broken ground states that prevail in nature. In this paper, we systematically explore the limitations of the HVA for solving symmetry-broken systems and propose an alternative quantum circuit Ansatz with symmetry-breaking layers. With extensive numerical simulations, we show that the proposed Ansatz finds the ground state in depth significantly shorter than the bare HVA when the target Hamiltonian has symmetry-broken ground states.
Adverse Childhood Experiences, Suicidality, and Aggression as Indicators of Polypharmacy Practice in Forensic Mental Health Systems
Authors: Stinson Jill D. , LeMay Carrie C. , Quinn Megan A.
Published: February 2024

Pharmacotherapy is a front-line intervention used to address complex health concerns among forensic system consumers. Many are prescribed a polypharmacy pharmacotherapy regimen, though this may pose significant risks to physical health and well-being. Forensic consumers also have evidence of behavioral health concerns that may impact preferred treatment and prescribing practices. We examined the relationship between ACEs, suicide, self-harm, and inpatient aggression with psychotropic polypharmacy using retrospective data extracted from medical records from a US forensic mental health facility ( N = 182). Nearly all participants (98.5%) prescribed any medication (72%) received a psychotropic polypharmacy regimen. ACEs were common, impacting 75.8% of the sample. ACEs, self-harm, and inpatient aggression, though not suicide attempts, were positively predictive of psychotropic polypharmacy in a series of regression analyses. Mediation analyses explored the interplay between ACEs, specific behavioral concerns, and psychotropic polypharmacy, though only models involving self-harm were significant. Implications for trauma-informed practice include an emphasis on consumer choice, empowerment, collaboration, and autonomy. Future research should investigate implementation of trauma-informed practices in forensic mental health settings and the effectiveness of nonpharmacological interventions that can be used to reduce dependence on psychotropic medications when managing forensic consumers’ health concerns.
Predictors of Nicotine Replacement Therapy Adherence: Mixed-Methods Research With a Convergent Parallel Design
Authors: Kim Sun S , Prasad Anyah , Nayak Manan M , Chen Hua , Srisoem Chaowalit , DeMarco Rosanna F , Castaldi Peter , Cooley Mary E
Published: February 2024

Background

Few studies have examined the effect of baseline attitudes toward nicotine replacement therapy (NRT) on its actual adherence in a smoking cessation intervention.

Purpose

This study (i) examined the predictability of baseline variables (quantitative data) on NRT adherence and (ii) explored the congruence of participants’ statements about NRT products (qualitative data) during counseling sessions with their baseline attitudes.

Methods

This is a mixed-methods research study using a convergent parallel design. Participants included 74 individuals in the treatment group who received behavioral counseling and combination NRT. A Poisson regression analysis was performed to identify baseline variables predicting NRT adherence. Thematic analysis was completed with a subset of participants (n = 38) who varied in NRT attitude scores and adherence. A joint display was created to integrate quantitative and qualitative data and discover convergence.

Results

Approximately 59% of the participants (41/74) used NRT continuously for ≥5 weeks. Having negative attitudes toward NRT and depressive symptoms predicted NRT adherence even after controlling for education and anxiety symptoms. Thematic analysis revealed that NRT adherence is a learning process that consists of the following three distinctive but interrelated phases: (i) information needs, (ii) comprehensive readiness, and (iii) experiential learning. Of the 38 participants, 34 (89.5%) showed convergence between baseline attitude scores and statements about NRT made during counseling sessions.

Conclusions

Individuals who have negative attitudes toward NRT are less likely to use the products in a smoking cessation intervention. Counselors should assess attitudes toward NRT at baseline and address them proactively during counseling sessions.
Machine learning for detection of heterogeneous effects of Medicaid coverage on depression
Authors: Goto Ryunosuke , Inoue Kosuke , Osawa Itsuki , Baicker Katherine , Fleming Scott L , Tsugawa Yusuke
Published: February 2024

In 2008, Oregon expanded its Medicaid program using a lottery, creating a rare opportunity to study the effects of Medicaid coverage using a randomized controlled design (Oregon Health Insurance Experiment). Analysis showed that Medicaid coverage lowered the risk of depression. However, this effect may vary between individuals, and the identification of individuals likely to benefit the most has the potential to improve the effectiveness and efficiency of the Medicaid program. By applying the machine learning causal forest to data from this experiment, we found substantial heterogeneity in the effect of Medicaid coverage on depression; individuals with high predicted benefit were older and had more physical or mental health conditions at baseline. Expanding coverage to individuals with high predicted benefit generated greater reduction in depression prevalence than expanding to all eligible individuals (21.5 vs 8.8 percentage-point reduction; adjusted difference = +12.7 [95% CI, +4.6 to +20.8]; P = 0.003), at substantially lower cost per case prevented ($16 627 vs $36 048; adjusted difference = −$18 598 [95% CI, −156 953 to −3120]; P = 0.04). Medicaid coverage reduces depression substantially more in a subset of the population than others, in ways that are predictable in advance. Targeting coverage on those most likely to benefit could improve the effectiveness and efficiency of insurance expansion.

This article is part of a Special Collection on Mental Health.
Exposure to per- and polyfluoroalkyl substances and breast cancer risk: a systematic review and meta-analysis of epidemiologic studies
Authors: Chang Che-Jung , Ish Jennifer L , Chang Vicky C , Daniel Meklit , Jones Rena R , White Alexandra J
Published: February 2024

We synthesized the epidemiologic evidence on the associations between per- and polyfluoroalkyl substances (PFAS) exposure and breast cancer risk. Our systematic review and meta-analysis included 18 and 11 articles, respectively, covering studies up to February 2023. The summary relative risks (RRs) estimated by random-effects meta-analyses did not support an association between PFAS and overall breast cancer risk (eg, a natural log (ln)-unit increase in serum/plasma concentrations [ng/mL] for perfluorooctanoate [PFOA] RR = 0.95; 95% CI, 0.77-1.18; perfluorooctane sulfonate [PFOS] RR = 0.98; 95% CI, 0.87-1.11). However, when limiting to studies that assessed exposures prior to a breast cancer diagnosis, we observed a positive association with PFOA (a ln-unit increase, RR = 1.16; 95% CI, 0.96-1.40). We also observed some possible heterogeneous associations by tumor estrogen and progesterone receptor status among postmenopausal breast cancer cases. No meaningful changes were observed after excluding the studies with high risk of bias (Tier 3). Based on the evaluation tool developed by the National Toxicology Program, given the heterogeneity across studies and the variability in timing of exposure measurements, the epidemiologic evidence needed to determine the association between PFAS exposure and breast cancer remains inadequate. Our findings support the need for future studies with improved study designs to determine this association.
Handling missing data when estimating causal effects with targeted maximum likelihood estimation
Authors: Dashti S Ghazaleh , Lee Katherine J , Simpson Julie A , White Ian R , Carlin John B , Moreno-Betancur Margarita
Published: February 2024

Targeted maximum likelihood estimation (TMLE) is increasingly used for doubly robust causal inference, but how missing data should be handled when using TMLE with data-adaptive approaches is unclear. Based on data (1992-1998) from the Victorian Adolescent Health Cohort Study, we conducted a simulation study to evaluate 8 missing-data methods in this context: complete-case analysis, extended TMLE incorporating an outcome-missingness model, the missing covariate missing indicator method, and 5 multiple imputation (MI) approaches using parametric or machine-learning models. We considered 6 scenarios that varied in terms of exposure/outcome generation models (presence of confounder-confounder interactions) and missingness mechanisms (whether outcome influenced missingness in other variables and presence of interaction/nonlinear terms in missingness models). Complete-case analysis and extended TMLE had small biases when outcome did not influence missingness in other variables. Parametric MI without interactions had large bias when exposure/outcome generation models included interactions. Parametric MI including interactions performed best in bias and variance reduction across all settings, except when missingness models included a nonlinear term. When choosing a method for handling missing data in the context of TMLE, researchers must consider the missingness mechanism and, for MI, compatibility with the analysis method. In many settings, a parametric MI approach that incorporates interactions and nonlinearities is expected to perform well.
The InterSECT Framework: a proposed model for explaining population-level trends in substance use and emotional concerns
Authors: Halladay Jillian , Sunderland Matthew , Chapman Cath , Teesson Maree , Slade Tim
Published: February 2024

Across high-income countries, adolescent emotional concerns have been increasing in prevalence over the past two decades and it is unclear why this is occurring, including whether and how substance use relates to these changing trends. On the other hand, substance use has been generally declining, and little is known about the role of emotional concerns in these trends. Several studies have explored the changes in co-occurring substance use and emotional concerns among adolescents over time, with mixed results and inconsistent messaging about the implications of the findings. In response, we developed a theoretical framework for exploring the intersection between trends in substance use and emotional concerns (InterSECT Framework). This framework includes a discussion and related examples for 3 core hypotheses: (1) strengthening of co-occurrence, or the “hardening” hypothesis; (2) co-occurrence staying the same, or the “consistency” hypothesis; and (3) weakening of co-occurrence, or the “decoupling” hypothesis. This framework seeks to guide the conceptualization, evaluation, and understanding of changes in the co-occurrence of substance use and emotional concerns over time, including outlining a research agenda informed by pre-existing research and youth perspectives.
Estimating effects of longitudinal and cumulative exposure to PFAS mixtures on early adolescent body composition
Authors: Kuiper Jordan R , Liu Shelley H , Lanphear Bruce P , Calafat Antonia M , Cecil Kim M , Xu Yingying , Yolton Kimberly , Kalkwarf Heidi J , Chen Aimin , Braun Joseph M , Buckley Jessie P
Published: February 2024

Few methods have been used to characterize repeatedly measured biomarkers of chemical mixtures. We applied latent profile analysis (LPA) to serum concentrations of 4 perfluoroalkyl and polyfluoroalkyl substances (PFAS) measured at 4 time points from gestation to age 12 years. We evaluated the relationships between profiles and z scores of height, body mass index, fat mass index, and lean body mass index at age 12 years (n = 218). We compared LPA findings with an alternative approach for cumulative PFAS mixtures using g-computation to estimate the effect of simultaneously increasing the area under the receiver operating characteristic curve (AUC) for all PFAS. We identified 2 profiles: a higher PFAS profile (35% of sample) and a lower PFAS profile (relative to each other), based on their average PFAS concentrations at all time points. The higher PFAS profile had generally lower z scores for all outcomes, with somewhat larger effects for males, though all 95% CIs crossed the null. For example, the higher PFAS profile was associated with a 0.50-unit lower (β = −0.50; 95% CI, −1.07 to 0.08) BMI z score among males but not among females (β = 0.04; 95% CI, −0.45 to 0.54). We observed similar patterns with AUCs. We found that a higher childhood PFAS profile and higher cumulative PFAS mixtures may be associated with altered growth in early adolescence.

This article is part of a Special Collection on Environmental Epidemiology.
Manipulation, deception, the victim’s reasoning and her evidence
Authors: Krstić Vladimir
Published: February 2024

This paper rejects an argument defending the view that the boundary between deception and manipulation is such that some manipulations intended to cause false beliefs count as non-deceptive. On the strongest version of this argument, if a specific behaviour involves compromising the victim’s reasoning, then the behaviour is manipulative but not deceptive, and if it involves exposing the victim to misleading evidence that justifies her false belief, then it is deceptive but not manipulative. This argument has been consistently used as a reason to reject the traditional analysis of human deception, according to which intentionally causing someone to acquire a false belief is sufficient for deception. And because the traditional analysis is also consistent with our most basic intuitions about deception, it does matter whether this argument succeeds.
Flexible females: nutritional state influences biparental cooperation in a burying beetle
Authors: Lambert Georgia A , Smiseth Per T
Published: February 2024

In species that provide biparental care, there is a sexual conflict between parents over how much each should contribute toward caring for their joint offspring. Theoretical models for the resolution of this conflict through behavioral negotiation between parents assume that parents cannot assess their partner’s state directly but do so indirectly by monitoring their partner’s contribution. Here, we test whether parents can assess their partner’s state directly by investigating the effect of nutritional state on cooperation between parents in the burying beetle Nicrophorus vespilloides. We used a two-by-two factorial design, in which a well-fed or food-deprived female was paired with a well-fed or food-deprived male. We found that females adjusted their level of care in response to both their own nutritional state and that of their partner and that these decisions were independent of their partner’s contribution. We found no evidence that males responded directly to the nutritional state. Males instead responded indirectly based on the contribution of their partner. Our results suggest that parents are able to assess the state of their partner, in contrast to what has been assumed, and that these assessments play an important role in the mediation of sexual conflict between caring parents.
TrajPy: empowering feature engineering for trajectory analysis across domains
Authors: Moreira-Soares Maurício , Mossmann Eduardo , Travasso Rui D M , Bordin José Rafael
Published: February 2024

Motivation

Trajectories, which are sequentially measured quantities that form a path, are an important presence in many different fields, from hadronic beams in physics to electrocardiograms in medicine. Trajectory analysis requires the quantification and classification of curves, either by using statistical descriptors or physics-based features. To date, no extensive and user-friendly package for trajectory analysis has been readily available, despite its importance and potential application across various domains.

Results

We have developed TrajPy, a free, open-source Python package that serves as a complementary tool for empowering trajectory analysis. This package features a user-friendly graphical user interface and offers a set of physical descriptors that aid in characterizing these complex structures. TrajPy has already been successfully applied to studies of mitochondrial motility in neuroblastoma cell lines and the analysis of in silico models for cell migration, in combination with image analysis.

Availability and implementation

The TrajPy package is developed in Python 3 and is released under the GNU GPL-3.0 license. It can easily be installed via PyPi, and the development source code is accessible at the repository: https://github.com/ocbe-uio/TrajPy/. The package release is also automatically archived with the DOI 10.5281/zenodo.3656044.
Phylogeography and ecological niche modelling of the South American cricetid rodent Graomys griseoflavus, with insights into its chromosomal evolution
Authors: Urquizo José H , Ferro Ignacio , Murgia Agustina , Pardiñas Ulyses F J , Martínez Juan J
Published: February 2024

The rodent Graomys griseoflavus has a wide geographical distribution in the Arid Diagonal of South America, showing variation in the diploid number (2n = 33–38) caused by three different Robertsonian (Rb) translocations. Two contrasting hypotheses have been proposed to explain the origin and evolution of this polymorphism: (i) unique and sequential events; or (ii) multiple and independent origins of Rb translocations. Here, we combined phylogeography and ecological niche modelling to elucidate the evolutionary history of G. griseoflavus and help to contrast these hypotheses. The results indicated a demographic increase that would have begun ~150 kya from the High Monte ecoregion. The spatial distributions of these populations were coincident with the areas of highest habitat suitability. The palaeoclimatic projections suggested the presence of two main glacial refugia coincident with the main genetic clusters. Graomys griseoflavus underwent two pulses of southward expansion at ~220 and ~210 kya. More recently (~20 kya), there was a secondary contact between the southern populations (Low Monte ecoregion) expanding northwards and the northern populations (High Monte ecoregion) expanding into marginal areas of the Chaco ecoregion. Combined with the cytogenetic evidence, our results support the multiple and independent origins of Rb translocations.
Regulation of early spermatogenesis in the giant prawn Macrobrachium rosenbergii by a GCL homolog
Authors: Molcho Jonathan , Albagly Dana , Levy Tom , Manor Rivka , Aflalo Eliahu D , Alfaro-Montoya Jorge , Sagi Amir
Published: February 2024

The germ cell-less gene is crucial for gonad development in various organisms. Early interventions in its expression suggested a regulatory role at the mitotic stages of spermatogenesis, and its early knockout resulted in complete sterility in Drosophila. Genomic and transcriptomic data available for the catadromous giant prawn Macrobrachium rosenbergii enabled the identification of a germ cell-less homolog for this species, which we termed MroGCL (mRNA accession number OQ533056). An open reading frame containing 494 amino acids and a typical evolutionarily conserved BTB/POZ domain suggests possible protein–protein interaction functions in keeping with the Drosophila germ cell-less protein. Genomic mapping of MroGCL showed a full length of 120 896 bases. Analysis of the temporal expression of MroGCL showed constant expression in early prawn embryonic and larval stages, but a significant increase 10 days after metamorphosis when crucial sexual differentiation processes occur in prawns. In adult animals, high expression was detected in the gonads compared to the somatic tissues. RNAi-based knock-down experiments showed that both the silenced and control groups reached advanced spermatogenic stages, but that there was a significant decrease in the yield of spermatozoa in about half of the silenced animals. This finding supports our hypothesis that MroGCL is crucial for mitosis during early stage spermatogenesis. In conclusion, this study contributes to the understanding of crustacean gonad development and provides a stepping stone in the development of environmentally valuable sterile crustacean populations.
Network-adjusted covariates for community detection
Authors: Hu Y , Wang W
Published: February 2024

Community detection is a crucial task in network analysis that can be significantly improved by incorporating subject-level information, ie, covariates. Existing methods have shown the effectiveness of using covariates on the low-degree nodes, but rarely discuss the case where communities have significantly different density levels, ie, multiscale networks. In this paper, we introduce a novel method that addresses this challenge by constructing network-adjusted covariates, which leverage the network connections and covariates with a node-specific weight for each node. This weight can be calculated without tuning parameters. We present novel theoretical results on the strong consistency of our method under degree-corrected stochastic blockmodels with covariates, even in the presence of misspecification and multiple sparse communities. Additionally, we establish a general lower bound for the community detection problem when both the network and covariates are present, and it shows that our method is optimal for connection intensity up to a constant factor. Our method outperforms existing approaches in simulations and a LastFM app user network. We then compare our method with others on a statistics publication citation network where 30% of nodes are isolated, and our method produces reasonable and balanced results. Our method is implemented in the R package NAC.
Intra-patient and inter-observer image quality analysis in liver MRI study with gadoxetic acid using two different multi-arterial phase techniques
Authors: Castagnoli Francesca , Faletti Riccardo , Inchingolo Riccardo , Villanacci Alberta , Ruggeri Valeria , Zacà Domenico , Koh Dow-Mu , Grazioli Luigi
Published: February 2024

Purpose

To evaluate intra-patient and interobserver agreement in patients who underwent liver MRI with gadoxetic acid using two different multi-arterial phase (AP) techniques.

Methods

A total of 154 prospectively enrolled patients underwent clinical gadoxetic acid-enhanced liver MRI twice within 12 months, using two different multi-arterial algorithms: CAIPIRINHA-VIBE and TWIST-VIBE. For every patient, breath-holding time, body mass index, sex, age were recorded. The phase without contrast media and the APs were independently evaluated by two radiologists who quantified Gibbs artefacts, noise, respiratory motion artefacts, and general image quality. Presence or absence of Gibbs artefacts and noise was compared by the McNemar’s test. Respiratory motion artefacts and image quality scores were compared using Wilcoxon signed rank test. Interobserver agreement was assessed by Cohen kappa statistics.

Results

Compared with TWIST-VIBE, CAIPIRINHA-VIBE images had better scores for every parameter except higher noise score. Triple APs were always acquired with TWIST-VIBE but failed in 37% using CAIPIRINHA-VIBE: 11% have only one AP, 26% have two. Breath-holding time was the only parameter that influenced the success of multi-arterial techniques. TWIST-VIBE images had worst score for Gibbs and respiratory motion artefacts but lower noise score.

Conclusion

CAIPIRINHA-VIBE images were always diagnostic, but with a failure of triple-AP in 37%. TWIST-VIBE was successful in obtaining three APs in all patients. Breath-holding time is the only parameter which can influence the preliminary choice between CAIPIRINHA-VIBE and TWIST-VIBE algorithm.

Advances in knowledge

If the patient is expected to perform good breath-holds, TWIST-VIBE is preferable; otherwise, CAIPIRINHA-VIBE is more appropriate.
The development of inherited cardiac conditions services: current position and future perspectives
Authors: Alway Thomas , Bastiaenen Rachel , Pantazis Antonis , Robert Leema , Akilapa Rhoda , Whitaker John , Page Stephen P , Carr-White Gerald
Published: February 2024

Background

Over the last two decades, inherited cardiac conditions (ICC) centres have emerged with the aim of improving outcomes for patients and their families, through early diagnosis, genetic testing, risk assessment and specialist treatment.

Sources of data

A literature search was performed using PubMed (https://pubmed.ncbi.nlm.nih.gov/). Commissioned ICC service reviews from NHS England, NHS Improvement and PHG Foundation were evaluated.

Areas of agreement

ICC patient management requires a multi-disciplinary approach. ICC services are predominantly based within tertiary centres. Despite expansion, provision of care remains inadequate to meet rising demands. Access to services is inconsistent, partly due to geographic variation and lack of standardized pathways.

Areas of controversy

The optimal ICC care model remains undecided, although there is growing interest in ‘hub-and-spoke’ networks, which could aid secondary and tertiary service integration and repatriation of care.

Growing points

Genetic mainstreaming is a priority for the Genomic Medicine Service Alliance. The benefits of telehealth and virtual clinics have been validated by their use during the COVID-19 pandemic. Other innovations to improve resource efficiency, such as clinical scientist–led and nurse-led clinics, show promise.

Areas timely for developing research

An update for the NHS ICC service specifications is planned that appears well timed given the rapid evolution of the ICC landscape in the decade since last review. This has the potential to address needs including national audit, standardized pathways and ICC networks to improve governance and equity of care. Delegation of commissioning for specialist services to integrated care systems may also provide opportunity for increased regional direction.
RNA methylation-related genes INHBB and SOWAHA are associated with MSI status in colorectal cancer patients and may serve as prognostic markers for predicting immunotherapy efficacy
Authors: Yin Yuehan , Yang Shangjiu , Huang Zhijian , Yang Zheng , Zhang Changhua , He Yulong
Published: February 2024

The role of RNA methylation is vital in the advancement and spread of tumors. However, its exact role in microsatellite instability in colorectal cancer (CRC) is still not fully understood. To address this gap in knowledge, this study investigated the impact of genes associated with RNA methylation on the prognosis and response to immunotherapy in individuals diagnosed with low microsatellite instability (MSI-L) or microsatellite stable (MSS) CRC. The differentially expressed genes (DEGs) in two groups of patients: those with high microsatellite instability (MSI-H) and those with MSI-L/MSS was thoroughly investigated and compared with aims of exploring the association between them and the 60 RNA methylation regulators. We employed these genes and developed an MSI-RMscore to establish a risk signature capable of forecasting patient outcomes. Furthermore, an investigation of the immunophenotypic traits was conducted encompassing patients categorized as high-risk and low-risk. By combining the MSI-RMscore and clinicopathological features, a predictive nomogram was developed, which was subsequently validated using the GEO database. Furthermore, immunohistochemistry was employed to establish the correlation between INHBB and SOWAHA and the MSI status, as well as patient prognosis. Our findings indicated that the high-risk subgroup exhibited unfavorable overall survival rates, reduced responsiveness to immune checkpoint blockers, elevated estimate scores, and increased infiltration of macrophages and fibroblasts. We also confirmed that INHBB and SOWAHA were associated with CRC patient prognosis and MSI status, as well as immunotherapy response. These findings suggest that targeting INHBB and SOWAHA could be a promising strategy to enhance patient responsiveness to immunotherapy.
Efficient conversion of glycerol into 1,2-propanediol over Cu/SiO2 catalyst prepared through impregnation assisted with crown ether
Authors: Sasaki Shun , Kurniawan Enggah , Yamada Yasuhiro , Sato Satoshi
Published: February 2024

A highly efficient and stable Cu/SiO2 catalyst was prepared via 12-crown-4-ether (12C4)-assisted impregnation and used in the vapor-phase conversion of glycerol to 1,2-propanediol (propylene glycol, PG) via acetol formation in an ambient hydrogen flow. The 12C4-Cu/SiO2 catalyst gave a PG yield of >97% due to a low rate of C–C cleavage to generate ethylene glycol. Under optimum conditions, the high catalytic performance was maintained for 98 h of time on stream.
Odor dilution sorting as a clinical test of olfactory function: normative values and reliability data.
Authors: Lötsch Jörn , Wolter Anne , Hähner Antje , Hummel Thomas
Published: February 2024

Clinical assessment of an individual’s sense of smell has gained prominence, but its resource-intensive nature necessitates the exploration of self-administered methods. In this study, a cohort of 68 patients with olfactory loss and 55 controls were assessed using a recently introduced olfactory test. This test involves sorting 2 odorants (eugenol and phenylethyl alcohol) in 5 dilutions according to odor intensity, with an average application time of 3.5 min. The sorting task score, calculated as the mean of Kendall’s Tau between the assigned and true dilution orders and normalized to [0,1], identified a cutoff for anosmia at a score ≤ 0.7. This cutoff, which marks the 90th percentile of scores obtained with randomly ordered dilutions, had a balanced accuracy of 89% (78% to 97%) for detecting anosmia, comparable to traditional odor threshold assessments. Retest evaluations suggested a score difference of ±0.15 as a cutoff for clinically significant changes in olfactory function. In conclusion, the olfactory sorting test represents a simple, self-administered approach to the detection of anosmia or preserved olfactory function. With balanced accuracy similar to existing brief olfactory tests, this method offers a practical and user-friendly alternative for screening anosmia, addressing the need for resource-efficient assessments in clinical settings.
Saphenous vein to the right coronary system from the right thoracic artery or the aorta. Long-term propensity-matched results of 2 groups
Authors: Prapas Sotirios , Katsavrias Konstantinos , Gaudino Mario , Puskas John D , Di Mauro Michele , Zografos Panayiotis , Guarracini Stefano , Linardakis Ioannis , Panagiotopoulos Ioannis , Di Marco Massimo , Papandreopoulos Styliani , Pomakidou Sofia , Totaro Antonio , Calafiore Antonio M
Published: February 2024

OBJECTIVES

Since 2000, we anastomosed the saphenous vein graft to the right coronary artery system using the stump of the right internal thoracic artery as inflow. The long-term results of patients where the right coronary artery was grafted with the right internal thoracic artery or the ascending aorta as saphenous vein inflow has not been reported.

METHODS

From 2000 to 2018, 699 consecutive patients had right internal thoracic artery elongated with saphenous vein (I-graft group, n = 358, 51.2%) or saphenous vein from the aorta (Ao-graft group, n = 341, 48.8%) on right coronary artery system. Inclusion criteria were age ≤75 years, bilateral internal thoracic arteries as a Y graft on the left system (three-vessel disease, n = 603, 86.3%) or as a left internal thoracic artery on left anterior descending and right internal thoracic artery elongated with saphenous vein on the right coronary artery system (two-vessel disease, n = 96, 13.7%), only 1 saphenous vein per patient. Propensity-matching identified 272 patients per group. One-hundred and twenty-two patients underwent coronary computed tomographic angiography to asses grafts patency after a median follow-up of 88 (65–93) months.

RESULTS

In the paired samples, there was no difference in the early outcome. Ten-year survival and freedom from death, non-fatal acute myocardial infarction and repeat revascularization were higher in I-graft group: 90.6 [standard error (SE): 2.0] vs 78.2 (SE: 5.3), P = 0.0266, and 85.2 (SE: 2.4) vs 69.9 (SE: 5.3), P = 0.0179. Saphenous vein graft, at a long-time follow-up, showed a higher patency rate (81.6% (SE: 7.0) vs 50.7% (SE: 7.9), P < 0.0001) and a smaller internal lumen diameter (2.7, standard deviation: 0.4 vs 3.4, standard deviation: 0.6 mm, P < 0.0001) when right internal thoracic artery was the inflow.

CONCLUSIONS

Grafting the right coronary artery with saphenous vein may entail higher patency rate and better outcome when the inflow is the right internal thoracic artery than when is the ascending aorta. Prospective randomized data are needed to test this hypothesis.
Extended autologous tracheal replacement by a novel pedicled thoraco-chondro-costal flap: a cadaveric proof of concept
Authors: de Frémicourt Kim , Wurtz Alain , Georgescu Dragos , Sarsam Matthieu
Published: February 2024

OBJECTIVES

Our aim was to report an anatomic model of an autologous flap based on the internal thoracic blood supply: the pedicled thoraco-chondro-costal flap; and establish the feasibility of various types of extended tracheal replacement with this novel flap, according to a newly proposed topographic classification.

METHODS

In a cadaveric model, a cervicotomy combined with median sternotomy was performed. The incision was extended laterally to expose the chest wall. The internal thoracic pedicle was freed from its origin down to the upper limit of the delineated flap to be elevated. The perichondria and adjacent periostea were incised longitudinally to remove cartilages and adjacent rib segments, preserving perichondria and periostea. A full-thickness quadrangular chest wall flap pedicled on internal thoracic vessels was then elevated and shaped into a neo conduit to replace the trachea with the pleura as an inner lining.

RESULTS

Various types of extended non-circumferential and full-circumferential tracheal replacements were achieved with this composite flap. No anastomosis tension was noticed despite the absence of release manoeuvres.

CONCLUSIONS

This model could represent a suitable autologous tracheal substitute, which is long, longitudinally flexible and eventually transversely rigid. No microsurgical vascular anastomoses are required. The technique is reproducible. The perichondria and periostea would regenerate vascularized neo-cartilaginous rings, potentially decreasing the need for long-term stenting. The inner pleural lining could potentially transform into ciliated epithelium as shown in previous preclinical studies.