bluuebunny/crossref_metadata_2025 huggingface dataset:
RESPOSTA DA SOJA POR NÚMERO DE GRÃOS POR PLANTA E PESO DE MIL SEMENTES SOB ADUBAÇÃO DE MAP PURIFICADO
Authors: Silva Fabio Barbosa Lopes da , Ramos Leonardo da Cunha , Almeida Lucas Borges , Pereira Wander Murilo Alves
Published: July 2023

O objetivo deste trabalho é avaliar o aumento da produtividade de grãos de soja e o peso de mil sementes (PMS) em resposta à adubação com MAP Purificado em diferentes estádios da planta. Sendo uma alternativa para uma maior produtividade e a resposta da soja sob a adubação do fósforo e nitrogênio, visto que é um nutriente de extrema importância para o aumento do rendimento da soja. Os estádios das plantas de soja, compreendendo: V4+V6, V+R1, V4+V6+R1, V4+V6+R1+R3 e o tratamento testemunha. O experimento foi realizado na fazenda Lagoa Bonita, localizada na cidade de Engenheiro Coelho - SP, sendo utilizado o delineamento em blocos casualizados, com 13 tratamentos e quatro repetições, totalizando 52 tratamentos. O produto aplicado foi um adubo foliar com fonte de nitrogênio e fósforo, com a concentração de 12% de nitrogênio (N) e 61% de fósforo (P2O5 - Pentóxido de difósforo), seu nome comercial é MAP Purificado da empresa HAIFA fertilizantes.
Modélisation d’une Erosion Hydrique A Partir Des Photographies Aériennes Par Drone : Cas De L’érosion Bolikango A Delvaux, Dans La Commune De Ngaliema
Authors: Abdallah Mohamed Abdallah
Published: July 2023

La ville province de Kinshasa connait une présence exponentielle des têtes d’érosion, surtout dans la commune de Ngaliema compte tenu de la topographie de cette dernière et de l’urbanisation anarchique, la population de cette entité territoriale se voit délaisser et préfère abandonner leurs parcelles menacées par des érosions pour trouver refuge dans des communes voisines. C’est ainsi que nous avons trouvé important d’aborder cette thématique, afin de proposer une démarche scientifique et technique qui pourra permettre à l’autorité de prendre des décisions responsables. Cet article se veut un guide technique sur la modélisation des phénomènes érosifs dans le souci d’avoir les données de base nécessaire pour bien projeter les études proprement dites sur la lutte antiérosive.Nous avons eu à positionner les GCPs dans des endroits accessibles de notre site, pour corriger le MNE pendant le traitement, afin d’avoir un modèle réaliste de notre zone d’étude. L’idée ici est de modéliser la zone érosive grâce aux prises de vue aérienne par drone, et pour cela, il a fallu suivre toutes les étapes de manière scientifique et technique pour aboutir à un résultat escompté.La zone considérée comme le bassin versant de l’érosion BOLIKANGO a une superficie estimée à 200 hectares, avec les levers ordinaires, c’est-à-dire station totale et autres, la tâche n’aurait pas été facile. La plus grande question était celle de trouver une approche qui prendra en compte le temps, la qualité des données, la précision du résultat attendu et les contraintes d’ordre sociétal car le travail devrait couvrir plusieurs zones frappées par la délinquance juvénile. La technique de drone combinée avec les GCPs mesurés par des techniques géodésiques répondait au mieux à cette problématique, raison pour laquelle nous avons adopté cette technique combinée, qui du reste nous a permis d’avoir des résultats impressionnants surtout sur la production du MNE qui, représentait sensiblement les comportements de l’érosion et avons constaté que la profondeur moyenne de cette érosion avoisinée 70 m sur une longueur totale de 1890 m.C’est grâce à la photogrammétrie, que nous avons su avoir les données de manière précise, et avons pu cartographier de façon claire toutes les zones d’apport et définir précisément la position de la rivière MAKELELE par rapport à l’érosion BOLIKANGO. Cette rivière serait comme un exutoire naturel dans lequel les eaux peuvent être dirigées en cas d’une étude de la lutte antiérosive de cette érosion.
Character Description of Children Personages in “Charlie and the Chocolate Factory” by Roald Dahl
Authors: Nasiba Khamrakhanova , Ruzmatova Dilnoza Ramatjanovna
Published: July 2023

The article aims to discuss the issue of morality and moral values with the help of characters of children’s book written by Roald Dahl. The main focus is mature and immature morality that helps parents and teachers to be aware of the moral values that young readers are to develop and understand in order to reach the level of being socially well-behaved in the community.
The Effect Of Digital Literacy And Business Strategy On The Performance Of Micro, Small, And Medium Enterprises (MSMES) In Culinary Industry In Padang City
Authors: Nurlina Nurlina , Del Rosa Yenni , Yanti Budi
Published: July 2023

This study aimed to determine the effect of digital literacy and business strategy on the performance of Micro, Small and Medium Enterprises in the Culinary Industry in Padang partially and simultaneously. Primary research data sources were collected from questionnaires. The research population was 361 Culinary Micro, Small and Medium Enterprises, and a sample of 193 Culinary Micro, Small and Medium Enterprises was determined by purposive sampling. All research variables met the provisions of the instrument test and the classical assumption test so that multiple linear regression data analysis could be carried out. The multiple linear regression equations Y = 0.401 + 0.492X1 + 0.247X2 + e indicated that digital literacy and business strategy significantly positively affect the performance of Culinary Micro, Small and Medium Enterprises in Padang partially and simultaneously.
Development Of Terrorism In The Asia Region Post The Marawi Rebellion
Authors: Hanifudin Achmad Fauzan , Priyanto Priyanto , Suhirwan Suhirwan , Sutanto Rudy
Published: July 2023

Acts of terrorism carried out by the Abu Sayyaf Insurgent Group and the Maute Clan in the Marawi region which was later called the Battle of Marawi which involved the IS (Islamic State) terrorist organization occupying the Marawi region, the capital of Lanao del Sur Province on South Mindanao Island, Philippines. The fighting quickly spread to various parts of the city and then showed the presence of an increasing threat of extremism that occurred in Southeast Asia. ASEAN as a regional organization is needed to provide a significant role in preventing and fighting transnational terrorism. This research then explores ASEAN's response to the issue of terrorism after the Battle of Marawi. Barriers to ASEAN regional organizations in conducting cooperation influenced ASEAN's response regarding counterinsurgency and counterterrorism strategies after the Battle of Marawi. Furthermore, to explain this, this study uses a qualitative research method with a literature approach.
Analysis of the Perception of Service Quality to Patient Satisfaction in the Royal Prima Hospital Inpatient Room in 2019
Authors: Septiawan Zeky , Girsang Ermi , Ramadhani Nasution Sri Lestari
Published: July 2023

o win the competition, hospitals must be able to provide satisfaction to customers. Service quality is closely related to customer satisfaction, therefore the better the service quality, the more satisfied customers are and vice versa. The purpose of this study was to analyze the effect of perceived service quality on patient satisfaction in the inpatient ward of the Royal Prima Hospital, Medan in 2019. This type of research is quantitative research with a cross sectional approach. The population in this study were all 46 patients treated in class I and 98 for class III, so the total was 146 people and the sample using the Slovin formula was obtained as many as 59 respondents. Data were analyzed by univariate, bivariate and multivariate analysis. The results obtained: 1) Perception of tangible influence on patient satisfaction, 2) Perception of reliability effect on patient satisfaction, 3) Perception of responsiveness effect on patient satisfaction and the most dominant influence on patient satisfaction, 4) Perception of assurance affects patient satisfaction, 5) Perception of empathy affects patient satisfaction. From the results of this study, it is expected that hospitals can provide training to health workers to improve the quality of hospital services.

Keywords: Patient Satisfaction, Quality of Service, Tangible, Reliability, Responsiveness, Assurance, Empathy
Alternative renewable energy in Bhutan: Key findings and policy recommendations
Authors: Malla Avishek , Dhananjayan Pugazenthi
Published: July 2023

Biomass and hydropower are the principal sources of energy in Bhutan. In the future too, the latter is expected to play a significant role in meeting the country’s electricity needs and in earning export revenue. But, for transportation and other purposes, the country still has to import fuel. It is in this context and because of the country’s high dependence on hydroelectricity, as well as due to rising energy usage and falling prices of other renewable energy commodities that it has been deemed necessary to look into other renewable energy sources to diversify the country’s energy mix and economy. Thus, in a concerted manner, the Royal Government of Bhutan (RGoB) has been exploring avenues of alternative renewable energy (ARE) sources. For this, the Department of Renewable Energy (DRE), has been entrusted with the responsibility of developing sustainable energy channels and promoting renewable energy technologies (RETs). This report analyses the achievements in the field of renewable energy in Bhutan and outlines the findings and recommendations so that the country is able to scale up its renewable energy capabilities.
Layanan Bimbingan Karir untuk Meningkatkan Motivasi Siswa Melanjutkan Pendidikan ke Perguruan Tinggi
Authors: Jannah Roikhatul
Published: July 2023

Penelitian ini bertujuan untuk meningkatkan perencanaan karir siswa dengan menggunakan layanan bimbingan karir. Teknik sampling yang digunakan adalah purposive random sampling. Penelitian ini menggunakan pendekatan kualitatif deskriptif, dengan menggunakan metode observasi, wawancara, dokumentasi, sampai pada analisis data sehingga persoalan menjadi jelas dan dapat digambarkan dengan jelas. Hasil dari pelaksanaan layanan bimbingan konseling karir dalam meningkatkan motivasi siswa melanjutkan studi siswa kelas XII SMK Negeri Purwosari yaitu dengan menggunakan layanan bimbingan karir dengan mendatangkan beberapa alumni yang melanjutkan studi ke perguruan tinggi, diantaranya. Setelah diberikan layanan bimbingan karir, motivasi Para siswa untuk melanjutkan keperguruan tinggi meningkat, dari 30 siswa yang awalnya 20% yang berkeinginan melanjutkan ke perguruan tinggi, setelah diadakan layanan bimbingan karir tersebut kini meningkat menjadi 85%. Dan siswa lebih antusias dan lebih giat lagi dalam belajar agar mereka bisa masuk ke perguruan tinggi yang mereka inginkan.
Estudio de algoritmos de inteligencia artificial más utilizados para el diagnóstico de diabetes mellitus tipo 2
Authors: Cuenca Andrade Gabriela , Guamán-Quinche René , Álvarez-Pineda Francisco , Chamba-Zaragocin Wilman , Guamán-Quinche José Oswaldo
Published: July 2023

La diabetes es la segunda causa de muerte a nivel mundial sobre todo en países de bajos recursos. En el Ecuador uno de cada diez personas es diagnosticado con diabetes mellitus tipo 2, esto es debido a factores de riesgo como: antecedentes familiares con diabetes, medicación, sedentarismo o mala alimentación. Por lo tanto, es indispensable hacer una Revisión Sistemática de Literatura sobre el estado del uso de técnicas o algorítmos de Inteligencia Artificial para el diagnóstico de diabetes mellitus tipo 2; con este fin de responder la pregunta: ¿Cuáles son las técnicas de inteligencia artificial aplicadas al diagnóstico de diabetes mellitus tipo 2?
PRAVO NA BESPLATNO OSNOVNO OBRAZOVANJE – OD IDEALA DO STVARNOSTI
Authors: Zdravković Ana M. , Begović Aleksandra A.
Published: July 2023

U radu su analizirani međunarodnopravni akti, sudske odluke međunarodnih i nacionalnih sudova i kvazisudskih tela, kao i praksa država u pogledu prava na osnovno obrazovanje. Za omogućavanje jednakog pristupa obaveznom osnovnom obrazovanju neophodno je da ono bude besplatno, što je i propisano međunarodnopravnim aktima. Međutim, rezultati istraživanja su pokazali da se ovaj standard različito tumači, a to dovodi do neujednačene prakse u državama. Ilustrativni primer su svakako bivše jugoslovenske republike, te će poseban deo rada biti posvećen analizi normativnog okvira i prakse Republike Srbije, koja i dalјe ne obezbeđuje besplatne udžbenike za osnovnu školu.
Infestation assessment of banana weevil (cosmopolites sordidus germar) in different banana-based farming systems in Arusha and Kilimanjaro regions, Tanzania
Authors:   , Mohamed Yusuph
Published: July 2023

The present study was conducted to determine population size, infestation level and farmer’s understanding of banana weevils in different banana-based farming systems (BFS) namely banana monoculture, banana-beans, banana-coffee and banana-maize. This was conducted by using banana pseudostem traps, coefficient of infestation method and standard interviewing. It was conducted from June to September 2017 in Nkoaranga, Mbuguni and Ngurdoto villages (Meru District) and Uduru, Uraa and Mbosho villages (Hai District) in Northern Tanzania. The physical and survey data collected were analyzed by using statistical packages of GENSTAT 11th edition and SPSS Version 21 respectively. There were significant differences (P<0.05) in the number of banana weevils in different BFS. The highest banana weevil population (29.2 banana weevils/trap/farm over the period of three months) was recorded in banana-maize followed by banana-beans (8.2 banana weevils/trap/farm over the period of three months); however, this reading was not significantly different from the banana-monoculture and banana-coffee farming systems. Such results not only indicated that different BFS experience different banana weevil infestation levels but also that the banana-maize system attracted more banana weevils than any other BFS in this study. Of the banana cultivars, Kimalindi recorded the highest (153 weevils per farm) number compared to other banana cultivars indicating that different banana materials attract differently banana weevils. The results also showed that banana weevil was ranked to be the first insect pest of banana and a problem for about 68.8% of banana farmers. The present study calls for more studies on identifying factors responsible for the highest population in a banana-maize farming system unlike in other BFS and how banana weevils can be managed in Tanzania.
Evaluation of tick repellency activity and toxicity of commiphora swynnertonii (burtt) exudates
Authors:   , Swai Disela Edwin
Published: July 2023

This thesis reports the repellency activity and toxicity of Commiphora swynnertonii exudates. The exudates were extracted using hexane and chloroform solvents. The crude extracts were tested for repellency activity at concentration of 110, 100, 90, 80, 70, 60 and 50 mg/ml against Rhipicephalus appendiculatus larvae. The crude extracts were further evaluated for the acute and subacute toxicity using albino mice and rats, respectively. The results showed that repellency activity appeared to be concentration and time dependent. In acute toxicity, oral administration of C. swynnertonii hexane and chloroform extract at a doses of 500, 1000, and 2000 mg/kg body weight induced no clinical signs of toxicity in the mice during 14 days of experimental period. However, C. swynnertonii chloroform extract showed some toxic properties in some of blood parameters and in vital organs (liver and kidney) of treated mice. In subacute toxicity, C. swynnertonii hexane extract showed significant change in some of hematological and biochemical parameters. Even though rats treated with C. swynnertonii chloroform extract did not develop any observable sign of toxicity, some toxic properties was observed in some of blood parameters and in vital organs (liver and kidney). It is concluded that, C. swynnertonii hexane and chloroform extracts considered as good repellency agents against Rhipicephalus appendiculatus larvae. For the toxicity evaluation, C. swynnertonii hexane extracts was nontoxic while C. swynnertonii chloroform extract had toxic properties deduced from change in blood parameters and internal organs of treated animals.
Terapia de Padres Separados: Una Forma de Terapia en Pareja Basada en los Vínculos
Authors: Arias Regina Giraldo
Published: July 2023

El presente artículo describe los postulados teóricos, así como los procedimientos y estrategias terapéuticas de la “Terapia de Padres Separados”, una intervención que se realiza con padres en proceso de separación, o ya divorciados, principalmente aquellos en litigio por la custodia de los hijos. Habitualmente el liticio parental se presenta por rupturas conflctivas de la pareja, conduciendo a grandes sufrimientos en toda la familia, pero principalmente en los hijos, quienes afectados emocionalmente sufren las consecuencias de la disputa entre los padres. La terapia de padres separados, es una propuesta de la autora del artículo, quien la ha venido desarrollando a través de su practica clínica con este tipo de parejas, la mayoría de ellas derivadas de los juzgados y comisarías de familia de Bogotá, Colombia. El objetivo de la terapia es lograr una relación adecuada "cordial" entre los padres; donde el amor por los hijos, el bienestar de la familia, y la tranquilidad y paz personal de cada uno de los progenitores son las claves para el cambio.
Be Colonial American Working Wife and Her Dear and Loving Husband Absent upon Some Public Employment: Deborah and Benjamin Franklin’s Married Life
Authors: Chylińska Bożenna
Published: July 2023

Although historians recognize Deborah Franklin’s abilities and accomplishments, she invariably suffers in comparison with her famous husband. She seems to have shared the fate of Anne Bradstreet a century earlier, whose worldly spouse, Simon, for years remained object of his wife’s tender affection and dutiful supervision of his affairs. The article attempts to examine and evaluate Mrs. Franklin’s immeasurable contribution to the Franklin household and business, which enabled Benjamin to act on the international arena and indulge in the frivolities of the contemporary high life, against his egalitarian declarations.
Central Corneal Thickness and Endothelial Cell Changes after Phacoemulsification in Patients with Diabetes Mellitus: A Prospective Study
Authors: Sharma Hans Raj , Kaur Anureet , Sharma Ashok K , Jabeen Asma , Choudhary Rohini
Published: July 2023

Introduction: Diabetes Mellitus (DM) has emerged as a significant cause of ocular morbidity. The toxic effects of hyperglycaemia spare no cell in the body and cornea, has also revealed certain changes in diabetic patients. Higher phacoemulsification time and power effect corneal endothelial cells. This can inflict an additional stress on the altered diabetic corneal endothelium. Aim: To compare the Central Corneal Thickness (CCT) thickness and endothelial Cell Density (CD) and morphology in Type 2 Diabetes Mellitus (T2DM) patients undergoing phacoemulsification with age-matched non diabetic controls undergoing phacoemulsification. Materials and Methods: A prospective, hospital-based, interventional study was conducted in the Department of Ophthalmology, Government Medical College, Jammu, Jammu and Kashmir, India. The duration of the study was nine months, from April 2021 to December 2021. The study included 50 patients with T2DM and 50 non diabetic controls. All patients underwent phacoemulsification performed by a single surgeon. The CCT and endothelial cell parameters were measured preoperatively and postoperatively at one week, six weeks and three months using Topcon specular microscope. Postoperative changes in the corneal endothelial cells were compared between the two groups for a period of three months. Statistical analysis was done by using the Statistical Package for Social Sciences (SPSS) version 25.0 (IBM Corp. Released 2017. Armonk, NY, USA). Categorical variables were analysed using Chi-square test and the groups were compared using Student’s t-test. Results: The mean age of the study participants was 63.22±7.52 years in diabetic group and 64.52±7.29 years in non diabetic group. Diabetic patients showed significantly greater corneal thickness than non diabetic controls (p=0.034). This pattern was observed till the last follow-up at three months. The endothelial cell parameters were comparable between diabetic and non diabetic patients. There was a fall in endothelial cell count in all patients postoperatively, but it was significantly higher in the diabetic patients at three months (p=0.048). Postoperatively, Co-efficient of Variation (CV) was significantly higher in diabetic patients (p=0.001) accompanied by a decreased hexagonality (p=0.039) at the end of three months. Conclusion: A diabetic cornea is different than a non diabetic cornea at the cellular level. Diabetics show accelerated corneal endothelial cell loss and greater variation in cell morphology in response to surgical stress. Diabetes mellitus is a risk factor for endothelial cell loss in patients undergoing cataract surgery.
Association of Reducing the Recommended Colorectal Cancer Screening Age With Cancer Incidence, Mortality, and Costs in Canada Using OncoSim
Authors: Kalyta Anastasia , Ruan Yibing , Telford Jennifer J. , De Vera Mary A. , Peacock Stuart , Brown Carl , Donnellan Fergal , Gill Sharlene , Brenner Darren R. , Loree Jonathan M.
Published: July 2023

Importance

Recent US guideline updates have advocated for colorectal cancer (CRC) screening to begin at age 45 years in average-risk adults, whereas Canadian screening programs continue to begin screening at age 50 years. Similarities in early-onset CRC rates in Canada and the US warrant discussion of earlier screening in Canada, but there is a lack of Canadian-specific modeling data to inform this.

Objective

To estimate the association of a lowered initiation age for CRC screening by biennial fecal immunochemical test (FIT) with CRC incidence, mortality, and health care system costs in Canada.

Design, Setting, and Participants/Exposures

This economic evaluation computational study used microsimulation modeling via the OncoSim platform.

Main Outcomes and Measures

Modeled rates of CRC incidence, mortality, and health care costs in Canadian dollars.

Results

This analysis included 4 birth cohorts (1973-1977, 1978-1982, 1983-1987, and 1988-1992) representative of the Canadian population accounting for previously documented effects of increasing CRC incidence in younger birth cohorts. Screening initiation at age 45 years resulted in a net 12 188 fewer CRC cases, 5261 fewer CRC deaths, and an added 92 112 quality-adjusted life-years (QALYs) to the cohort population over a 40-year period relative to screening from age 50 years. Screening initiation at age 40 years yielded 18 135 fewer CRC cases, 7988 fewer CRC deaths, and 150 373 QALYs. The cost per QALY decreased with younger birth cohorts to a cost of $762 per QALY when Canadians born in 1988 to 1992 began screening at age 45 years or $2622 per QALY with screening initiation at age 40 years. Although costs associated with screening and resulting therapeutic interventions increased with earlier screening, the overall health care system cost of managing CRC decreased.

Conclusions and Relevance

This economic evaluation study using microsimulation modeling found that earlier screening may reduce CRC disease burden and add life-years to the Canadian population at a modest cost. Guideline changes suggesting earlier CRC screening in Canada may be justified, but evaluation of the resulting effects on colonoscopy capacity is necessary.
The Role of Ear, Nose, and Throat Specialists in the Nose-to-Brain Pathway
Authors: Radulesco Thomas , Serrano Elie , Michel Justin
Published: July 2023

This Viewpoint discusses the role of ear, nose, and throat specialists in the understanding, development, growth, and administration of direct nose-to-brain delivery route devices and therapies.
Monitor unit verification for Varian TrueBeam VMAT plans using Monte Carlo calculations and phase space data
Authors: Pant Ankit , Miri Narges , Bhagroo Stephen , Mathews Joshua A. , Nazareth Daryl P.
Published: July 2023

To use the open‐source Monte Carlo (MC) software calculations for TPS monitor unit verification of VMAT plans, delivered with the Varian TrueBeam linear accelerator, and compare the results with a commercial software product, following the guidelines set in AAPM Task Group 219. The TrueBeam is modeled in EGSnrc using the Varian‐provided phase‐space files. Thirteen VMAT TrueBeam treatment plans representing various anatomical regions were evaluated, comprising 37 treatment arcs. VMAT plans simulations were performed on a computing cluster, using 107–109 particle histories per arc. Point dose differences at five reference points per arc were compared between Eclipse, MC, and the commercial software, MUCheck. MC simulation with 5 × 107 histories per arc offered good agreement with Eclipse and a reasonable average calculation time of 9–18 min per full plan. The average absolute difference was 3.0%, with only 22% of all points exceeding the 5% action limit. In contrast, the MUCheck average absolute difference was 8.4%, with 60% of points exceeding the 5% dose difference. Lung plans were particularly problematic for MUCheck, with an average absolute difference of approximately 16%. Our EGSnrc‐based MC framework can be used for the MU verification of VMAT plans calculated for the Varian TrueBeam; furthermore, our phase space approach can be adapted to other treatment devices by using appropriate phase space files. The use of 5 × 107 histories consistently satisfied the 5% action limit across all plan types for the majority of points, performing significantly better than a commercial MU verification system, MUCheck. As faster processors and cloud computing facilities become even more widely available, this approach can be readily implemented in clinical settings.
A Coenzyme‐Based Deep Eutectic Supramolecular Polymer Bioadhesive
Authors: Cui Chunyan , Sun Yage , Nie Xiongfeng , Yang Xuxuan , Wang Fushuo , Liu Wenguang
Published: July 2023

α‐lipoic acid (LA), a coenzyme, has proved to have excellent antioxidant and antibacterial activities; however, its intrinsic hydrophobicity and metastability of polyLA remains a major challenge for the application of LA‐based bulk materials in biomedical field. Herein, a self‐stabilized LA‐based deep eutectic supramolecular polymer (LA‐DESP) adhesive is created by one‐step heating the mixture of LA and sodium α‐lipoate (LA‐Na) (S‐, R‐isomer, racemate) without introducing any exogenous stabilizing molecules. The underlying deep eutectic effect in LA/LA‐Na is unveiled to be originated from the multiple hydrogen bonds between polyLA and polyLA‐Na, which not only prevent polyLA depolymerization but also lower the melting point of LA‐DESP to the near body and pathological temperature. Copolymerization of LA and LA‐Na slows down the dissociation of polyLA‐Na, thus affording sustainable release of bioactive LA‐based small molecules and satisfactory antioxidant and antibacterial functions. Also, the LA‐DESP exhibits fast and tough adhesion to diverse substrates, including wet tissues, relying on its in situ curing property and rich carboxyl groups. The LA‐DESP is explored as a tissue sealant, which can well replace surgical suture to enhance the wound healing of skin incision in a rat model. The unprecedented deep eutectic effect will provide a new strategy for the development of LA‐based bioadhesives.
Unlocking the Potential of Field Effect Transistor (FET) Biosensors: A Perspective on Methodological Advances in Computational and Molecular Biology
Authors: Rexha Jesmina , Perta Nunzio , Roscioni Agnese , Motta Stefano , La Teana Anna , Maragliano Luca , Romagnoli Alice , Di Marino Daniele
Published: July 2023

Field‐effect transistor (FET)‐based sensors are increasingly gaining relevance in diagnostic, healthcare, and environmental monitoring applications. A FET operates by transducing chemical interactions between a surface‐immobilized bioreceptor and the target analyte into a detectable electrical signal. FET biosensors can detect and monitor molecules (i.e., biomarkers, small molecules, viruses, bacterias) present in liquid samples, making a “liquid gate” configuration of FETs the most suitable approach. However, this FET architecture presents dimensional constraints that affect bioreceptors’ stability and immobilization in the liquid phase. To overcome these limitations, herein, a combination of computational and molecular biology techniques for improving bioreceptors' applicability in biosensing is proposed. This results in the optimized and problem‐tailored protein receptors for specific FET biosensors applications, thus enhancing their overall performance. The interplay between the computational and experimental approaches will represent a ground‐breaking solution for the development of next‐generation biosensors.
A Learning‐Based Sensor Array for Untethered Soft Prosthetic Hand Aiming at Restoring Tactile Sensation
Authors: Xu Haipeng , Rong Yu , Ren Jieji , Zhang Ningbin , Zhao Yi , Yang Xinyu , Zhu Zhenpu , Gu Guoying
Published: July 2023

Endowing tactile feedback for prosthetic hands is profound for upper‐limb amputees. However, existing prosthetic hands are generally not in possession of the embedded sensory feedback. Herein, a flexible tactile sensor array which can be integrated into an untethered soft prosthetic hand to achieve static and dynamic discrimination tasks is presented. The flexible piezoresistive sensory arrays with 25 sensor units which can be arranged on five fingers of the soft prosthetic hand are fabricated. According to the collected large‐scale tactile dataset (including pressure distribution and pressure magnitude) during different grasping tasks, a learning‐based classification model that can reveal the correspondences between tactile information and object attributes while interacting with touched objects is developed. To transfer tactile information extracted from tactile sensor arrays, a wearable vibrotactile feedback band with a spatial coding feedback strategy is implemented by selectively activating vibrotactile motors located on the skin of the upper arm. In a set of tests performed by an individual with transradial amputation and eight able‐bodied subjects, the soft prosthetic hand integrated with tactile sensor arrays can help the users regain finger tactile sensation, discriminate grasped objects, and achieve real‐time dynamic rolling detection.
Microsupercapacitors Working at 250 °C
Authors: Mishukova Viktoriia , Su Yingchun , Chen Shiqian , Boulanger Nicolas , Xu Bo , Thangavelu Hari Hara Sudhan , Sun Jinhua , Xia Wei , Talyzin Alexandr , Li Jiantong
Published: July 2023

The raised demand for portable electronics in high‐temperature environments (>150 °C) stimulates the search for solutions to release the temperature constraints of power supply. All‐solid‐state microsupercapacitors (MSCs) are envisioned as promising on‐chip power supply components, but at present, nearly none of them can work at temperature over 200 °C, mainly restricted by the electrolytes which possess either low thermal stability or incompatible fabrication process with on‐chip integration. In this work, we have developed a novel process to fabricate highly thermally stable ionic liquid/ceramic composite electrolytes for on‐chip integrated MSCs. Remarkably, the electrolytes enable MSCs with graphene‐based electrodes to operate at temperatures as high as 250 °C with a high areal capacitance (~72 mF cm−2 at 5 mV s−1) and good cycling stability (70 % capacitance retention after 1000 cycles at 1.4 mA cm−2).
Highly efficient expression and secretion of human lysozyme using multiple strategies in Pichia pastoris
Authors: Wang Yasen , Wang Buqing , Gao Yahui , Nakanishi Hideki , Gao Xiao‐Dong , Li Zijie
Published: July 2023

Background

Human lysozyme (hLYZ), an emerging antibacterial agent, has extensive application in the food and pharmaceutical industries. However, the source of hLYZ is particularly limited.

Results

To achieve highly efficient expression and secretion of hLYZ in Pichia pastoris, multiple strategies including G418 sulfate screening, signal sequence optimization, vacuolar sorting receptor VPS10 disruption, and chaperones/transcription factors co‐expression were applied. The maximal enzyme activity of extracellular hLYZ in a shaking flask was 81,600 ± 5230 U mL−1, which was about five times of original strain. To further reduce the cost, the optimal medium RDMY was developed and the highest hLYZ activity reached 352,000 ± 16,696.5 U mL−1 in a 5 L fermenter.

Conclusion

This research provides a very useful and cost‐effective approach for the hLYZ production in P. pastoris and can also be applied to the production of other recombinant proteins.
Examining the effects of a modified SART when measuring mind‐wandering
Authors: liu Yuqing , Dong Qin , Yu ChengHao , Jin YuTong , Fang ChenYuan , Hu Yu , Zhou Qiang
Published: July 2023

Objective

Mind‐wandering (MW) is defined as a shift of attention from external tasks toward internal thoughts and is popularly measured by the sustained attention to response task (SART). SART is able to capture MW, but cannot track the dynamics of mind‐wandering over time well. We thus attempted to modify the sustained attention to response task paradigm (mSART) to capture the participant's mind‐wandering state over time and quantify the degree of mind‐wandering using the current behavioral data.

Methods

179 participants from Wenzhou Medical University were recruited to participate in this experiment. The main changes to the experiment included (1) manipulating different no‐go stimuli frequencies to control the difficulty of the task and setting 9 modes; (2) extending the experiment time to 30 min; (3) allowing participants to correct errors by pressing the b key. Error rate, Mean RTs, RT CV, and d' were used to reflect MW. Analysis of covariance (ANCOVA) was performed.

Results

ANOVA was used to explore Mean RTs, RT CV and d’ for participants with different levels of mind‐wandering and significant differences were found (Mean RTs:Welch's F (2, 8606.04) = 579.00, p < .001, ηp2 = 0.03; RT CV:Welch's F (2, 198.11) = 69.93, p < .001, ηp2 = 0.18; d':F (2, 176) = 19.88, p < .001, ηp2 = 0.18). The 30‐min experiment was divided into six time windows, and mind‐wandering deepens over time.

Conclusions

The mSART paradigm could quantify the extent of MW based on changes in the frequency at which the no‐go stimuli were presented and also revealed that the recommended length of the experiment was about 20 min.
Nut consumption and urogenital and genital, gastrointestinal and women‐related cancers: Assessment and review
Authors: Mohamadi Maryam , Dousdampanis Periklis , Ahmadi Zahra , Pourmasumi Soheila , Naderi Monavare , Zainodini Nahid , Nazari Alireza
Published: July 2023

The prevalence of cancer, especially in industrial countries, is a major problem for health and treatment systems. Cancer can affect the quality of life of all family members and has many negative effects on the community. Despite many advances in cancer treatment, this disease is still a major worldwide problem. There is strong evidence that dietary habits are effective in protecting against cancer and even helping in the disease treatment progress. Nuts with various biologically‐active compounds, such as vitamins, phytosterols, isoflavones, flavonoids, and polyphenols have been reported to possess anticarcinogenic properties. Accordingly, this review provides an insight into the association between nut consumption and the prevention of some cancers. We considered the cancers related to the urogenital and genital tract, gastrointestinal tract, as well as women‐related cancers. Both cell culture examinations and experimental animal studies alongside observational epidemiological studies demonstrated that regular consumption of a nut‐enriched diet is able to reduce the risk of these cancers.
Risk of decreased ovarian reserve in women with HPV infection and cervical lesions
Authors: Fakor Fereshteh , Gashti Nasrin G. , Fallah Amirhossein H. , Kabodmehri Roya , Rafiei Sorouri Zahra , Hasanzadi Aida , Pourhabibi Zahra
Published: July 2023

Background

Human papillomavirus (HPV) infection has been considered an important involved factor for infertility. Since one of the causes of decreased ovarian reserve is oophoritis due to viral infections, this study aimed to evaluated the association between HPV infection and ovarian reserve.

Methods

This case‐control study was performed on 219 women aged 25–35 years who were referred to the gynecologic oncology clinic during 2019–2020. The positive or negative HPV infection was confirmed by cervical biopsy and polymerase chain reaction (PCR) test. Cervical lesions or abnormalities in the cervix were assessed by colposcopy and histopathological analysis. Serum anti‐Mullerian hormone (AMH) levels were measured for all participants to assess ovarian reserve.

Results

The results of this study showed that in patients who were HPV positive, decreased ovarian reserve was more common than in the HPV negative group (p = 0.0001). Also, there was a significant difference between Cervical intraepithelial neoplasia (CIN) I and CIN III sub‐groups in AMH level (p = 0.0001).

Conclusions

Traces of HPV have been observed in various aspects of infertility, but no study has been performed on its association with ovarian reserve. According to the results of this study, decreased ovarian reserve was more common in patients who were HPV positive.
Shallow and local or deep and regional? Inferring source groundwater characteristics across mainstem riverbank discharge faces
Authors: Haynes Adam B. , Briggs Martin A. , Moore Eric , Jackson Kevin , Knighton James , Rey David M. , Helton Ashley M.
Published: July 2023

Riverbank groundwater discharge faces are spatially extensive areas of preferential seepage that are exposed to air at low river flow. Some conceptual hydrologic models indicate discharge faces represent the spatial convergence of highly variable age and length groundwater flowpaths, while others indicate greater consistency in source groundwater characteristics. Our detailed field investigation of preferential discharge points nested across mainstem riverbank discharge faces was accomplished by: (1) leveraging new temperature‐based recursive estimation (extended Kalman Filter) modelling methodology to evaluate seasonal, diurnal, and event‐driven groundwater flux patterns, (2) developing a multi‐parameter toolkit based on readily measured attributes to classify the general source groundwater flowpath depth and flowpath length scale, and, (3) assessing whether preferential flow points across discharge faces tend to represent common or convergent groundwater sources. Five major groundwater discharge faces were mapped along the Farmington River, CT, United States using thermal infrared imagery. We then installed vertical temperature profilers directly into 39 preferential discharge points for 4.5 months to track vertical discharge flux patterns. Monthly water chemistry was also collected at the discharge points along with one spatial synoptic of stable isotopes of water and dissolved radon gas. We found pervasive evidence of shallow groundwater sources at the upstream discharge faces along a wide valley section with deep bedrock, as primarily evidenced by pronounced diurnal discharge flux patterns. Discharge flux seasonal trends and bank storage transitions during large river flow events provided further indication of shallow, local sources. In contrast, downstream discharge faces associated with near surface cross cutting bedrock exhibited deep and regional source flowpath characteristics such as more stable discharge patterns and temperatures. However, many neighbouring points across discharge faces had similar discharge flux patterns that differed in chloride and radon concentrations, indicating the additional effects of localized flowpath heterogeneity overprinting on larger scale flowpath characteristics.
Cross‐talk of pyroptosis‐based subtypes, the development of a risk classifier and immune responses in cervical cancer
Authors: Gu Jiamin , Ding Bo
Published: July 2023

Background

Cervical cancer (CC) is one of the most common gynecology malignancies and has a dismal survival outcome. The prognostic value of pyroptosis and its role in the regulation of immune metabolism in CC remain unclear.

Methods

Two independent CC cohorts collected from public databases were integrated for unsupervised cluster analysis. All CC cases were assigned to different subsets based on the pyroptosis‐related genes (PRGs). The differentially expressed genes (DEGs) between different subclusters were included in stepwise Cox regression for the risk classifier establishment. Next, single‐cell sequencing analysis was conducted to explore the cellular location of each model gene. The CIBERSORT algorithm was applied to estimate immunocytes infiltration. Finally, a series of functional experiments were performed to detect the role of CDH3 in CC.

Results

Based on the 52 PRGs, the combined CC cohort was clustered into two subsets (C1 (n = 259) and C2 (n = 242)). Survival and Cox regression methods were used to create a pyroptosis‐based risk classifier including four PRGs (PEG3, FSCN1, CDH3 and SLC2A1). For the immune environment in CC, the high‐risk group had a lower infiltration level of B cells, memory‐activated CD4 T cells and CD8 T cells and a higher infiltration abundance of neutrophils. The expression pattern of model genes was confirmed in CC cell lines by PCR assay. Furthermore, we observed that knockdown of CDH3 could suppress CC cell proliferation.

Conclusion

Our project could offer promising reference for prognosis assessment, immune metabolism prediction and clinical decision‐making of patients with CC.
Understanding the Black male experience: Recommendations for clinical, community, and school settings
Authors: Burt Isaac , Hines Erik M. , Moore James L.
Published: July 2023

The characterizations of Blackness and maleness are stark and pervasive throughout the theoretical and scientific literature. Too often, Black males occupy a vicarious and distinctive position in American society. The depictions of Black males are rarely casted in a positive manner. Instead, an overpowering image of incompetence, unintelligence, complacency, and propensity to result to violence consumes the livelihood of Black males in the United States. Thus, despite these perceptions, they have been resilient, successful, and stubbornly resistant to negative typecasts. Moreover, there has to be a better awareness and understanding of the educational challenges and psychological and social struggles that Black males endure as “they define who they are, build and maintain relationships, cope with racism, and search for strengths in the African American way of being”. Further, more research is needed to better support Black males in clinical, community, and school settings. This special issue on the Black male experience is a step in this direction. To that end, the Journal of Multicultural Counseling and Development (JMCD) presents five theoretical, qualitative, and quantitative articles focusing specifically on the Black male experiences in both clinical and educational contexts. Each article, in its own way, amplifies the importance of culturally responsive approaches.
Assessment of projected climate change impact on agro‐climatic indicators in Poland
Authors: Marcinkowski Paweł , Piniewski Mikołaj , Jefimow Maciej
Published: July 2023

This study presents a long‐term assessment of the impact of projected climate change on selected agro‐climatic indicators in Poland. The analysis was based on an ensemble of six bias‐corrected EURO‐CORDEX projections covering the period from 2006 to 2100 under Representative Concentration Pathways: RCP4.5 and 8.5, and partly on simulations of an agro‐hydrological Soil and Water Assessment Tool model. The indicators included growing season (length, beginning, and ending date), growing degree days, frost days, accumulated frost, and planting and harvest timing. The study focused on four major crops cultivated in Poland, namely spring barley, rapeseed, maize silage, and potato. The analysis revealed a significant future increase in precipitation and mean temperature in Poland reaching +10.3% and 3.4°C by the end of century, respectively. Warmer conditions will significantly accelerate the beginning of the growing season (by up to 24 days) and delay its ending (by up to 18 days), consequently significantly extending its length throughout the country (by up to 42 days). A decrease is projected in potential soil moisture deficit by up to 26 mm by the end of century in the high‐end emission scenario. A significant advancement (by up to 30 days) in planting timing is projected for the future for all crops under consideration. A significant increase in growing degree days (by up to 760°C‐days) will also advance the harvest timing (by up to 54 days). The projected temperature increase over the winter season will result in a significant decrease in frost days (by 56 days) and accumulated frost (by 375°C‐days), which may lead to an increased presence of pests. This study can provide a scientific basis for assessing the future risks to the local agriculture from climate change and will be beneficial in planning adaption and mitigation actions for food security at the national and local scale.
Tribological characteristics evaluation of a helical gear pair based on the tribo‐dynamic model
Authors: Liu Mingyong , Han Xinguang , Yan Chunai , Ouyang Zhouhuan , Qi Dezhong
Published: July 2023

In this paper, a tribo‐dynamic model of a helical gear is established. For the lubrication sub‐model, a finite line thermal elastohydrodynamic lubrication model of helical gear is adopted. The lateral vibration, axial vibration of gear and torsional vibration of the gear shaft are considered in the dynamic sub‐model. Results show that the tribological parameters of helical gear under the tribo‐dynamic model deviate significantly from that of the quasi‐static model, especially in the engaging‐in region of tooth pair. The friction excitation mainly affects the vibration along the off‐line‐of‐action direction of the gears. The influence of operating conditions on the tribological and dynamic properties of a helical gear pair is significant, especially in the case related to the characteristic frequency of gears.
MXene‐Based Soft Actuators with Multiresponse and Diverse Applications by a Simple Method
Authors: Xu Mengjie , Li Lin , Zhang Wei , Ren Zhen , Liu Jinquan , Qiu Changwen , Chang Longfei , Hu Ying , Wu Yucheng
Published: July 2023

Smart actuators that can convert external energy stimuli into mechanical energy output have great potential in industrial, biomedical, and military applications. However, the existed disadvantage such as complex fabrication process, single stimulus source, and the requirement of artificial energy restrict their further development. Herein, a MXene/polyethylene (PE)‐based soft actuator with multistimulus response and the ability to be driven by natural sunlight and human humidity is proposed through a simple method. Owing to the excellent electrical conductivity, high photothermal conversion capability, and surface hydrophilicity of MXene, the MXene/PE actuator exhibits rapid and large bending deformation in response to external multistimuli such as light, electricity, heat, and humidity. Owing to the simple preparation, and anisotropic, tailorable and programmable properties of the MXene/PE actuator, a soft robot that can crawl directionally under light conditions is constructed. In addition, based on the high sensitivity response of the actuator to light and humidity, smart clothing that can generate reversible bending deformation under natural sunlight as well as sweat conditions is developed. These results provide a new inspiration for the design of high‐performance soft actuators with multistimulus response, and demonstrate the potential applications of the MXene/PE actuators in smart devices, bionic robots, and wearable clothing.