bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanisms and Implications of Mitochondrial Autophagy in Stroke
Authors: Sultan Rabia , Zou Qing , Cao Yiyang , Hong Huanle , Sun Ruiqi , Zhuang Cheng , Zhao Robert Chunhua , Wang Jiao
Published: October 2024

Stroke is an acute cerebrovascular disease that is caused by disruptions in the cerebral blood supply and leads to brain tissue damage. Its pathological mechanisms remain to be fully elucidated. Stroke has high incidence, disability, and mortality rates, thus substantially affecting life and health. Against this backdrop, intracellular mitochondria, which are central to cellular energy metabolism and crucial for cell survival, have major roles in ischemic stroke. Ischemic stroke results in brain cell oxygen and nutrient deprivation, thereby triggering oxidative stress and inflammatory reactions, impairing mitochondrial function, and disrupting energy metabolism. Mitochondrial autophagy is a protective mechanism to improve the quality and quantity of mitrochondria, and exerts neuroprotective effects. In recent years, preserving mitochondrial function after ischemic stroke has emerged as a major research topic. Increasing evidence suggests a close relationship between abnormal mitochondrial autophagy and the occurrence, progression, and pathophysiology of ischemic stroke. However, current research has not adequately explained how ischemic stroke regulates the initiation and execution of mitochondrial autophagy. Elucidating this mechanism in detail will be critical for understanding the development of stroke injury, and identifying novel and effective intervention strategies. Additionally, the optimal treatment time window must be determined to enable effective interventions in mitochondrial autophagy and minimize brain damage. To deepen understanding of mitochondrial autophagy, this review summarizes mitochondrial autophagy’s signaling pathways and its major role in ischemic stroke pathophysiology. Further exploration in this field will provide a crucial theoretical foundation for developing novel therapeutic strategies and clinical applications.
Oscillatory Brain Activity in the Canonical Alpha-Band Conceals Distinct Mechanisms in Attention
Authors: Cruz Gabriela , Melcón María , Sutandi Leonardo , Matias Palva J. , Palva Satu , Thut Gregor
Published: October 2024

Brain oscillations in the alpha-band (8–14 Hz) have been linked to specific processes in attention and perception. In particular, decreases in posterior alpha-amplitude are thought to reflect activation of perceptually relevant brain areas for target engagement, while alpha-amplitude increases have been associated with inhibition for distractor suppression. Traditionally, these alpha-changes have been viewed as two facets of the same process. However, recent evidence calls for revisiting this interpretation. Here, we recorded MEG/EEG in 32 participants (19 females) during covert visuospatial attention shifts (spatial cues) and two control conditions (neutral cue, no-attention cue), while tracking fixational eye movements. In disagreement with a single, perceptually relevant alpha-process, we found the typical alpha-modulations contra- and ipsilateral to the attention focus to be triple dissociated in their timing, topography, and spectral features: Ipsilateral alpha-increases occurred early, over occipital sensors, at a high alpha-frequency (10–14 Hz) and were expressed during spatial attention (alpha spatial cue > neutral cue). In contrast, contralateral alpha-decreases occurred later, over parietal sensors, at a lower alpha-frequency (7–10 Hz) and were associated with attention deployment in general (alpha spatial and neutral cue < no-attention cue). Additionally, the lateralized early alpha-increases but not alpha-decreases during spatial attention coincided in time with directionally biased microsaccades. Overall, this suggests that the attention-related early alpha-increases and late alpha-decreases reflect distinct, likely reflexive versus endogenously controlled attention mechanisms. We conclude that there is more than one perceptually relevant posterior alpha-oscillation, which need to be dissociated for a detailed account of their roles in perception and attention.
The Excessive Tonic Inhibition of the Peri-infarct Cortex Depresses Low Gamma Rhythm Power During Poststroke Recovery
Authors: Alasoadura Michael , Leclerc Juliette , Hazime Mahmoud , Leprince Jérôme , Vaudry David , Chuquet Julien
Published: October 2024

The cortex immediately surrounding a brain ischemic lesion, the peri-infarct cortex (PIC), harbors a large part of the potential to recover lost functions. However, our understanding of the neurophysiological conditions in which synaptic plasticity operates remains limited. Here we hypothesized that the chronic imbalance between excitation and inhibition of the PIC prevents the normalization of the gamma rhythm, a waveband of neural oscillations thought to orchestrate action potential trafficking. Probing the local field potential activity of the forelimb primary sensory cortex (S1FL) located in the PIC of male adult mice, we found a constant, deep reduction of low-gamma oscillation power (L-gamma; 30–50 Hz) precisely during the critical time window for recovery (1–3 weeks after stroke). The collapse of L-gamma power negatively correlated with behavioral progress in affected forelimb use. Mapping astrocyte reactivity and GABA-like immunoreactivity in the PIC revealed a parallel high signal, which gradually increased when approaching the lesion. Increasing tonic inhibition with local infusion of GABA or by blocking its recapture reduced L-gamma oscillation power in a magnitude similar to stroke. Conversely, the negative allosteric modulation of tonic GABA conductance using L655,708 or the gliopeptide ODN rescued the L-gamma power of the PIC. Altogether the present data point out that the chronic excess of ambient GABA in the PIC limits the generation of L-gamma oscillations in the repairing cortex and suggests that rehabilitative interventions aimed at normalizing low-gamma power within the critical period of stroke recovery could optimize the restitution of lost functions.
The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-Actin
Authors: Mirfakhar Farzaneh S. , Castanheira Jorge , Domingues Raquel , Ramalho José S. , Guimas Almeida Cláudia
Published: October 2024

CD2-associated protein (CD2AP) was identified as a genetic risk factor for late-onset Alzheimer's disease (LOAD). However, it is unclear how CD2AP contributes to LOAD synaptic dysfunction underlying AD memory deficits. We have shown that loss of CD2AP function increases β-amyloid (Aβ) endocytic production, but it is unknown whether it contributes to synapse dysfunction. As CD2AP is an actin-binding protein, it may also function in F-actin-rich dendritic spines, which are the excitatory postsynaptic compartments. Here, we demonstrate that CD2AP colocalizes with F-actin in dendritic spines of primary mouse cortical neurons of both sexes. Cell-autonomous depletion of CD2AP specifically reduces spine density and volume, resulting in a functional decrease in synapse formation and neuronal network activity. Postsynaptic reexpression of CD2AP, but not blocking Aβ production, is sufficient to rescue spine density. CD2AP overexpression increases spine density, volume, and synapse formation, while a rare LOAD CD2AP mutation induces aberrant F-actin spine-like protrusions without functional synapses. CD2AP controls postsynaptic actin turnover, with the LOAD mutation in CD2AP decreasing F-actin dynamicity. Our data support that CD2AP risk variants could contribute to LOAD synapse dysfunction by disrupting spine formation and growth by deregulating actin dynamics.
VALORIZATION OF ARTICHOKE LEAF POWDER IN EXTRUDED SNACKS: PRODUCT QUALITY AND IN VITRO STARCH DIGESTIBILITY
Authors: Çaltinoğlu-toraman Çağla , Güven Özge , Şensoy İlkay
Published: October 2024

Artichoke waste is a rich source of fibers and bioactive phenolic substances. The study aimed to investigate the effect of artichoke leaf powder (ALP) addition on physical properties and in vitro starch digestibility of wheat flour (WF) - based extrudates. Feeds were prepared to have extrudates with ALP:WF ratios of 0:100, 3:97, 6:94, and 9:91. Increasing ALP ratio reduced sectional and volume expansion indexes but increased bulk density and hardness values. The water absorption index decreased for the highest ALP: WF ratio (9:91), while the water solubility index was not affected by ALP addition. Rapidly and slowly digestible glucose fractions were not significantly affected by ALP addition. The overall acceptability of products was only affected at the 9:91 ALP: WF ratio. The findings showed that ALP could be valorized as a food ingredient. The information gained could guide future studies that will focus on developing nutritious ready-to-expanded snacks enriched with high fiber ingredients.
Key factors influencing the implementation of virtual reality in employee training
Authors: Kristl Volfova Monika , Egerova Dana
Published: October 2024

Virtual reality (VR) is rapidly becoming more popular and accessible. With the growing popularity of its use in the corporate sphere, there are already a number of publications that focus on adapting this modern technology to employee training. Unfortunately, they only focus on certain areas and lack a comprehensive view. This study focused on this research gap and is one of the first (and in the Czech Republic, the very first) studies investigating the key factors influencing the implementation of VR in employee training. The Delphi method was implemented using a total of 22 deliberately selected experts according to pre-selected criteria to ensure sufficient and relevant data. The Delphi method was conducted in 3 rounds, and 59 factors were obtained, which were divided into positive and negative, at the same time, in both these areas, the factors were categorized into 5 dimensions, which were determined based on the modified Khan’s framework. In the analysis of the third round, Kendall’s coefficient of concordance was calculated for each group. This study represents a significant contribution to the research on virtual reality as a tool for employee training. Moreover, the findings of the study are beneficial for companies, managers and human resources managers in terms of successfully implementing virtual reality into employee training.
Rapid drops of ocean temperatures in several shallow bays in Nova Scotia during a recent cold air outbreak
Authors: Casey Michael P. , Petrie Brian , Lu Youyu , MacDermid Sarah , Paquin Jean-Philippe
Published: October 2024

Abstract
From February 3-5, 2023 Atlantic Canada experienced an extremecold Arctic air outbreak with high winds that set many local meteor-ological records, including wind chills as low as -47°C. The impacts of the cold air outbreak on ocean temperatures and ice formation are investigated using predictions from the Coastal Ice-Ocean Prediction System for the East Coast of Canada (CIOPS-E), developed by Environment and Climate Change Canada. Observations from moorings further inform the predictions. The analysis suggests that during the event, several shallow bays and coastal areas in Nova Scotia experienced significant, abrupt temperature decreases ranging from 1.0 to 3.9°C. Overall cooling estimated by the model was 2.3°C for nearshore locations where observations recorded an average temperature decrease of 3.0°C. On the other hand, at individual sites the difference between observed and modelled cooling was up to 2.4°C. This difference can be attributed partly to the fact that the model does not adequately resolve the coastline features of some of the nearshore mooring sites.
In comparison, we also analyze another cold air outbreak that occurred on December 15-18, 2016, with wind chills as low as -37°C. The ocean temperatures changes associated with this earlier event saw decreases of 0.8 to 3.5°C, potentially contributing to an ongoing fish kill in St. Mary’s Bay (near the mouth of the Bay of Fundy) at the time. 
Keywords: Ocean temperature, Cold air outbreak, Ocean forecasting, Shallow bays, Nova Scotia
Soundwaves in the North Atlantic: Detecting the offshore bats of Sable Island
Authors: Doucette Kayla M. , Patriquin Krista J. , Broders Hugh G. , Horn Andrew G.
Published: October 2024

As Sable Island National Park Reserve approaches a decade of protection under Parks Canada, new data on the island’s biodiversity is useful for informing management. An ultrasonic autonomous recording unit was deployed for 15 months over two years (October 5, 2015-January 8, 2017) to quantitatively characterize the presence of bats on Sable Island. A total of 1721 echolocation passes were identified across the 32 nights that bats were detected on the island (6.9% of total recording nights). Of the nights that bats were detected, Lasionycteris noctivagans (Silver-haired Bat) was present on 65% of nights, Myotis species were present on 53% of nights, Lasiurus borealis (Eastern Red Bat) was present on 25% of nights, and Lasiurus cinereus (Hoary Bat) was present on 6.25% of nights. All recordings were captured between late-September and early-December. Evidence of bat species on Sable Island, whether deliberately stopping during migration or brought there by external factors such as weather, highlights that the island may be more important for bats than previously thought.
Keywords: bats, bioacoustics, migration, monitoring, Sable Island
Scatarie Island Excursion
Authors: Bird Hank M.B.
Published: October 2024

N/A
Pendidikan Karakter Religius Peserta Didik SMP Negeri 3 Kendal Melalui Program Pembiasaan Jumat Takwa
Authors: Achmad Listanto Nugroho  , Natal Kristiono
Published: October 2024

Pendidikan karakter adalah upaya dan usaha yang dilaksanakan secara sadar dan sistematis yang bertujuan untuk membentuk karakter peserta didik menjadi lebih baik. Sekolah adalah salah satu unsur pendidikan yang memiliki peran penting dalam pelaksanaan pendidikan karakter di Indonesia. Pendidikan karakter religius merupakan salah satu bentuk pendidikan karakter yang berusaha mewujudkan peserta didik yang memiliki karakter dan sikap yang bersumber atau didasarkan pada nilai-nilai agama atau kepercayaan.Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan kualitatif deskriptif. Lokasi penelitian dilaksanakan di sekolah yang bersangkutan yaitu SMP Negeri 3 Kenda dengan fokus penelitian pada pelaksanaan dan dampak dari program pembiasaaan Jumat takwa di SMP Negeri 3 Kendal. Untuk data yang peneliti peroleh berasa dari sumber data primer dengan menggunakan teknik pengumpulan data observasi dan wawancara, serta sumber data sekunder dengan menggunakan teknik dokumentasi dan mengkaji dari berbagai literatur. Dalam penelitian ini, uji keabsahan data dilakukan dengan cara trianggulasi sumber dan teknik. Teknik analisis data dilakukan dengan cara pengumpulan data dan mereduksi data dengan menyajikan data, dan verifikasi data.Pembiasaan Jumat Takwa merupakan salah satu program pendidikan karakter yang dilaksanakan di SMP Negeri 3 Kendal yang bertujuan untuk mewujudkan peserta didik yang beriman, bertakwa, dan berakhlak mulia. Pembiasaan Jumat Takwa yang berisi kegiatan keagamaan terbukti berpengaruh positif terhadap karakter religius peserta didik di SMP Negeri 3 Kendal. Pembiasaan Jumat takwa yang dilaksanakan di SMP Negeri 3 Kendal berisi kegiatan-kegiatan keagamaan yaitu membaca surat yasin dan tahil, membaca surat Al Kahfi, sholat dhuha berjamaah dan doa bersama. Kegiatan pembiasaan Jumat takwa diikuti oleh seluruh peserta didik SMP Negeri 3 Kendal yang semuanya memeluk agama Islam. Secara umum, pembiasaan Jumat takwa memberikan pengaruh yang positif terhadap karakter religius peserta didik SMP Negeri 3 Kendal baik berhubungan dengan Allah Subhanahu Wa Ta’ala yang menandakan manusia sebagai makhluk Tuhan, maupun dalam menjalin hubungan yang baik dengan sesama manusia sebagai makhluk sosial. Penyataan tersebut ditandai dengan meningkatnya motivasi dan semangat peserta didik dalam melaksanakan kegiatan-kegiatan yang terdapat didalam pembiasaan Jumat takwa. Indikator yang kedua adalah terjadi perubahan sikap peserta didik khususnya dalam menghormati dan memuliakan guru sebagaimana pernyataan narasumber.
Prevalence and risk factors associated with erectile dysfunction in adults
Authors: Onchi Luis Alberto Herrera , García Anel Gómez , Hernández Brenda Paullette Morales
Published: October 2024

Introduction: Erectile dysfunction (ED) and associated risk factors represent a health problem that significantly affects the quality of life (QoL) of men worldwide, with individual, family, psychological and sexual involvement. Objective: To determine the prevalence of erectile dysfunction and associated risk factors in patients aged 30 to 65 years. Methods: Cross-sectional, descriptive study. To outpatients of HGZ/MF No.2, from December 2022 to May 2023, aged 30 to 65 years, who agree to participate in the study. Those under antidepressant treatment were excluded. Sociodemographic and clinical variables were analyzed. The IIEF-5 questionnaire was used to evaluate erectile dysfunction and the Montgomery-Asberg Scale for depression. Descriptive statistics and Chi2 were used to determine association between categorical variables with significant p-value <0.05 and SPSS v.23 for data analysis. Results: 206 participants were surveyed with mean age 46.42 ± 10.18 years, 62.62%(n=129) with arterial hypertension, 36.89%(n=76) with diabetes mellitus, 44.7%(n=92) with dyslipidemia and 38.40%(n=79) depression. 47.5%(n=98) presented some degree of erectile dysfunction, light 42.22%(n=87), mean 5.3%(n=11). We found association between ED with age [p<0.001], blood pressure stage [p<0.001], DM2 [p<0.001], smoking [p=0.001], BMI [p=0.002], physical activity [p<0.001] and depression [p<0.001]. Conclusions: Erectile dysfunction was present in half of the surveyed users, finding association with comorbidities; being important as first level physicians, the adequate metabolic control in them, promoting physical activity and a mental health for its prevention.
Queens Survival during Pleometrosis in Monogynous and Polygynous Ant Species (Hymenoptera, Formicidae)
Authors: Stukalyuk S. , Stelia V.
Published: October 2024

The objective of this study is to examine the survival rates of queens in pleometrotic groups of two ant species: Lasius paralienus Seifert, 1992 (a monogynous species) and Solenopsis fugax (Latreille, 1798) (a polygynous species). The study was conducted in 2020 and 2021 in Odesa, Ukraine. After the nuptial flight, 45 gynes of S. fugax and 64 of L. paralienus were captured. Solenopsis fugax were seated in groups of 5 (9 experiments in total), L. paralienus in groups of 5 (8 experiments) and 3 specimens (8 experiments). For L. paralienus, the effect of pleometrotic group size on the queens was tested. Maximum duration of the experiment was 115 days for S. fugax and 293 days for L. paralienus (until only one queen remains or the number of queens does not change significantly). The number of queens (alive, dead and killed), workers and brood were counted once a week. There were no significant differences in mortality between groups of 3 and 5 queens of Lasius paralienus ants (p = 0.06). The period of main queen mortality occurs shortly after founding of the pleometrotic group. Mortality continues to rise after the emergence of a group of 10–30 workers until only 1 queen remains in group of Lasius. When L. paralienus queens died naturally, the average number of workers was 7.5, the average number of larvae was 3.32 and the average number of pupae was 5.16. However, when they died due to fights, the average number of workers was 23.89, the average number of larvae was 8.89 and the average number of pupae was 13.89. In the case of S. fugax, when queens died naturally, the average number of workers was 5.43. A comparison of the total queen mortality in the pleometrotic groups of the two ant species showed that most queens survive in the polygynous S. fugax, whereas all but one die in the monogynous Lasius.
Morphometric and Meristic Characters of a Small Indigenous Freshwater Balitorid, Triplophysa marmorata (Cypriniformes, Nemacheilidae), from Manasbal Lake, Kashmir, India
Authors: Mushtaq S. T. , Mushtaq S. A. , Shah T. H. , Bhat F. A.
Published: October 2024

The current study investigates the morphometric and meristic characteristics of a small indigenous freshwater balitorid, Triplophysa marmorata, thriving in Manasbal Lake, Kashmir, India. The research involved the collection of 360 samples of Triplophysa marmorata from Manasbal Lake. A detailed investigation was carried out on 18 morphometric and 6 meristic characters of Triplophysa marmorata specimen whose length ranged from 28.66 to 164.1 cm. The analysis revealed that the morphometric measurements were dependent on body size and there was a gradual increase in body length. Regression analysis was performed between the independent variables TL and the dependent variables viz. SL, FL, PrAL, PrVL, PrDL, BD, HL, CFL, PFL and PVL as well as between the dependent variables HL and the dependent variables ED, SnL, PrOL and PoL. The results indicated a positive relation between various morphometric characters and both TL and HL, displaying correlations that ranged from medium to high strength. On the other hand the fish showed constant meristic characters where there was no change in meristic counts with the increase of body length. The fin formula is derived as D 6–9; P 8–10; V 6–7; A 4–6; C 13–18. The findings demonstrated characteristic morphometric traits exclusive to Triplophysa marmorata in Manasbal Lake establishing crucial data for future investigations into the biological dynamics and conservation objectives pertaining to the fish.
Genetic Algorithm Optimization of Hybrid LSTM-AutoEncoder in Tourism Recommendation System
Authors: Sanjaya Bayu Surya Dharma , Setiawan Erwin Budi
Published: October 2024

The tourism industry has rapid growth and has become one of the world's leading economic industries in recent years due to advances in information technology, such as the internet and social media. However, the overwhelming amount of information often makes it difficult for travelers to decide on their preferred travel destination. To address these issues, this research proposes a tourism recommendation system that combines Content-Based Filtering and Hybrid LSTM-AE, which is optimized using Genetic Algorithm (GA). There is no research that has developed a recommendation system using a combination of these methods and optimized using GA. So that this research can contribute to providing personalized recommendations and higher accuracy. The dataset consists of 9,504 ratings collected from the Ministry of Tourism and Creative Economy, Twitter, and web sources. The system was able to achieve a rating prediction accuracy of 96.82% by applying SMOTE to handle data imbalance and implementing a GA approach to the Hybrid LSTM-AE model. Accuracy has increased by 18.7% from the baseline model without using SMOTE and optimization. These results underscore that a strong integration between natural language processing and genetically optimized deep learning provides more accurate recommendations.
Transparency and altruistic punishment in an experimental model of cooperation to corruption through economic games
Authors: Duarte-Barroso Juan José , Cruz Torres Christian Enrique
Published: October 2024

This work integrates cooperation, punishment, damage to the treasury, and the transgression of norms in a single experimental model of corruption. Participants formed words with predetermined letters, receiving a reward for each word, and, if they reached a goal, an extra taken from the common fund. Manipulation in the letters made it impossible to reach the goal, so reporting exceeding it implied cheating for a benefit. Three studies model the effects of signaling, descriptive norms, and the possibility of punishing or investigating (transparency) corruption acts. 248 participants were randomly assigned to the conditions of each study. Significant differences were found in reports of words and earnings in Studies 1 and 3, but not in Study 2. The experimental model reveals the potential of transparency as an alternative of lower social cost than altruistic punishment to diminish corruption. The relevance of these results for implementing public policies was discussed.
Structural, electronic, and optical-absorption properties of 2D Si thin films
Authors: Saunders Nicholas , Palchoudhury Soubantika , Jakowski Jacek , Huang Jingsong
Published: October 2024

Recent experimental studies highlighted the potential of thin-film crystalline silicon (Si) for high-efficiency solar cells. Using density functional theory, we investigated 2D Si thin films across various orientations, thicknesses, and surface structures to elucidate their structure–property relationships. Through surface-energy calculations and Wulff construction, we determined the crystal habit of Si, which aligns with available experimental observations. Electronic-structure calculations underscored the critical role of valence saturation on surfaces in enabling semiconducting behavior in Si thin films, essential for optical applications. From optical-absorption calculations, we identified the surface index exhibiting the highest absorption coefficients for thin films Si solar cell applications.

Graphical abstract
A Brief Inquiry into the History of Everyday Aesthetic Ideas. Care of the Home in the Thought of Socrates and Xenophon
Authors: Di-Stefano Elisabetta
Published: October 2024

Emerged as a new philosophical trend, Everyday Aesthetics shifts focus from Arts to daily practices and objects. However, its historical dimension remains relatively unexplored. Adopting a historical approach inspired by Tatarkiewicz, this paper addresses this gap by examining the notions of home care in the thoughts of Greek philosophers Socrates and Xenophon. Analyzing Xenophon’s works reveals how ancient concepts of order and beauty apply to daily life, enriching contemporary Everyday Aesthetics discussions on cleanliness and domestic care.
Estética de lo cotidiano y transculturalidad. «Por los caminos de Asia Oriental»
Authors: Fernández-Gómez Rosa
Published: October 2024

El artículo defiende la dimensión transcultural de la estética de lo cotidiano a partir de las premisas de la estética pragmatista. A partir de la noción deweyana de ritmo se tenderán puentes con la estética china clásica y con ejemplos de las artes del pincel se ilustrará cómo la cotidianidad es una de las protagonistas clave de sus temáticas. La dimensión cíclica de la temporalidad será clave para completar esta visión estética de la cotidianidad.
Una ontología indiferenciada: la Estética Cotidiana entre Oriente y Occidente
Authors: Molina-Barea María-del-Carmen
Published: October 2024

Este trabajo rastrea los pilares definitorios de la Estética Cotidiana a partir del análisis de dos nociones básicas: desinterés y Einfühlung. Se aborda primero la tradición estética occidental erigida sobre estos conceptos, y después el posicionamiento diferencial de la estética japonesa. El artículo contrasta ambas posturas y sitúa a la Estética Cotidiana entre una y otra, argumentando su conexión con la estética japonesa como alternativa a la estética desinteresada y empática de Occidente.
The Language of Anti-Digital Resistance: Features of Protest Nomination Formation in Russian-Language Media Texts
Authors: Marinova Elena
Published: October 2024

The specifics of the word formation reflecting the certain protest of a society part against the Digital Society concept implementation in the country are considered on the material of Russian-language media texts. The aim of the study is to determine the semantic dominants and pragmatic peculiarities of the new nominations as the interpretive language function realization. The analysis of the material is carried out in line with functional sociolinguistics using the methodology of establishing the cognitive conditionality of language processes. The research resulted in revealing the contents of nominations, which reflect the protest attitude towards the concept of Digital Society. According to the type of the referent the following groups of lexical units are identified: the nominations of digitalization members, of the process itself and its consequences, as well as the foreseen future. The word-building peculiarities of the protest nominations are noted, their role in the key term elements structure of the Digital Society language is emphasized. The ‘restriction of freedom’ has been revealed to be the common semantic dominant of the new nominations. The coining of the units under consideration is characterized by the use of label-words and word-building formants that are typical of protest nominations. The semantic modification of the Digital Society terms shifts towards the ideologisation of meaning. The language and rhetoric of the official Digital Society concept followers, using their own ideologemes and word markers, are opposed to the language of the anti-digital resistance. The research outlook is in the analysis of pseudo arranging Digital Society nominations, which disguise the actual state of affairs.
Metalanguage in the Reflection of Its Functions
Authors: Kravchenko Michail
Published: October 2024

The research is devoted to the topical issues of linguistics, determined by the necessity of clarifying the scientific approaches to identification of the natural language functions, systematization of data on its metalanguage function, and the construction of a scientifically grounded representation of the metalanguage function implementation in a modern text (discourse). The relevance of the work is explained by the increased number and diversity of metalanguage contexts in modern communicative practice. The paper represents the results of a comprehensive study and description of the content and variants of manifestation in the text (discourse) of the metalanguage function of the language. The taxonomy of metalanguage functions is presented on the material of modern Russian literature works. The metalanguage is revealed to perform two basic functions: information research and modelling. The information and research function has an ontological basis and is characterized by a substantial heterogeneity, which made it possible to identify a number of specific functions: metaphatic, explanatory, characterizing, evaluative, searching, connecting and categorizing. The modelling function has psychological foundations, meaningfully aimed at creative understanding of the code for the purpose of its subsequent processing and creative use in speech activity, which provides a new modelling of reality. It is shown that when updating this function, the potential of pun, or play on words, is widely used. It is established that the modelling function is characterized by the implicitness of its realization in the text.
“New Sincerity” Interview Strategies: Million Dollar Questions and Smaller Conversational Exchanges
Authors: Issers Oxana , Gerasimova Anastasia
Published: October 2024

The article deals with the techniques of building a dialogue in the interview genre that encourage the interlocutor to be sincere. The intrusion of a journalist into the addressee’s private space, as well as the interviewee’s expression of their own identity through answers to “uncomfortable” questions can be considered as the discursive indicators for determining whether a text belongs to the tendency of “new sincerity” described in the present paper. The material of the study includes text fragments from the interviews of the Russian journalists with famous cultural figures and politicians published in the media or posted on the Internet platforms within the period of 2018–2023. It has been established that in order to determine the markers of “new sincerity” in the genre of a journalistic interview, one should consider the following essential discursive characteristics: thematic variety, methods of requesting (finding out) information by a journalist, the interlocutor’s reaction to a question that is on the borderline between public and private communication, techniques of euphemization and implication/explication of taboo meanings. “New sincerity” is found, first of all, in the expanded zone of thematic freedom acceptable in public communication. The main topics discussed in journalistic interviews, which reveal this trend (finances, health, appearance, etc.) are described in the article. The subject of the study is various methods of stimulating the “confessional” statement of the interlocutor and their latter’s reaction to violations of the acceptable boundaries of sincerity in public communication. The study also reveals metalinguistic markers of “new sincerity” that represent the strategies of speech behavior of both the journalist and their interlocutor. The results of the study show that “new sincerity” is becoming a technology that is used in mass media as a tool to influence the audience; thereby it shapes the communicative culture of the society in the public space.
Multiple substance use and associated factors in transgender women and travestis: findings from the TransOdara Study, Brazil
Authors: da Mota Jurema Corrêa , Sperandei Sandro , De Boni Raquel Brandini , Dourado Inês , Veras Maria Amélia de Sousa Mascena , Bastos Francisco Inácio
Published: October 2024

ABSTRACT Objective To estimate the prevalence of concomitant substance consumption and analyze associated risk factors in a non-probabilistic sample of the Brazilian population of transgender women and travestis. Methods A cross-sectional study was conducted with recruitment via respondent-driven sampling. The sample included transgender women and travestis residing in São Paulo, Porto Alegre, Salvador, Manaus, and Campo Grande, aged 18 years or older, between 2019 and 2021. The outcome was the concomitant use of licit and illicit substances. The association between sociodemographic/behavioral factors and the outcome was analyzed through Poisson regression with mixed effects. Adjusted prevalence ratios (confidence interval of 95% — 95%CI) were estimated. Results The prevalence in the last 12 months of multiple substance use was 49.3%, of which 65.5% were alcohol, 52.9% tobacco, and 40.1% marijuana. Transgender women and travestis who use multiple substances face more violence (1.71; 95%CI 1.14–2.55), unemployment (1.58; 95%CI 1.05–2.37) and pervasive unstable work status (1.52; 95%CI 1.08–2.14), transactional sex (1.51; 95%CI 1.21–1.88) which can be their sole option to make a living, and are aged 18 to 24 years (1.37; 95%CI 1.14–1.65). Conclusion The use of multiple substances may be an attempt to cope with distress and marginalization. Substance use has been associated with multiple harms and medical conditions. Comprehensive management and care should be provided, as defined by the key principles of the Brazilian Unified Health System. Health care should be integrated into structural interventions.
Chinese Double Effect on Brazilian Foreign Policy (2003-2018)
Authors: Coutinho Yuri Bravo , Rodriguez Júlio César Cossio
Published: October 2024

Abstract This research examines contemporary Brazilian foreign policy, and its central concern is to explore how China’s global rise has impacted the general guidelines of Brazilian foreign policy from 2003 to 2018. We argue that China has had a double impact on Brazilian foreign policy: (i) restraining its scope due to the restrictive nature of Sino-Brazilian relations, primarily via commerce and political divergence, and (ii) enhancing Brazil’s autonomous insertion in the international system due to the structural gaps produced by Chinese diplomatic support in the global sphere and from the convergence of specific agendas. A case study on Sino-Brazilian relations is conducted with typologies on foreign policy actions elaborated by Schweller (1994). Then, we propose that Brazilian foreign policy, through the ‘bandwagoning for profit’ strategy, sought to interpret a Jackal position within the international system. Our variables are defined based on Ripsman, Taliaferro and Lobell (2016), considering the structural stimulus of China’s rise as the independent variable, the permissiveness, and clarity of the international system as the intervening variable, and the behaviour of Brazilian foreign policy as a dependent variable.
Uncertainty reduction in MASW inversion and ground response analysis using a-priori information
Authors: Desai Aniket , Jakka Ravi S.
Published: October 2024

The method of multi-channel analysis of surface waves (MASW) is commonly used for estimating the shear wave velocity (Vs) profile of soil and subsequent ground response analysis (GRA). However, the uncertainties from inversion non-uniqueness in MASW testing and the absence of soil type information in GRA can undermine their accuracy and affect seismic designs. Incorporating a-priori information from geotechnical investigations can be a potential solution, but its effectiveness in MASW testing is not well understood. The aim of this study is to quantify the uncertainty reduction achieved by incorporating a-priori information in MASW testing and GRA. Extensive numerical simulations of MASW and GRA for nine idealised soil profiles were carried out. Subsequently, the findings were validated by carrying out field testing with and without a-priori information. The a-priori information included number and thickness of soil layers, soil type and index properties. The findings demonstrate that incorporating a-priori information significantly reduces inversion uncertainty in MASW and GRA, enhancing the reliability and accuracy of the analyses. This work provides a quantitative assessment of uncertainty reduction using a-priori information for different possible site and earthquake scenarios. The findings have important implications for the design of earthquake-resistant structures and for improving the safety of people and infrastructure in earthquake-prone areas.
Heavy metal immobilisation with microbial-induced carbonate precipitation: a review
Authors: Omoregie Armstrong Ighodalo , Ouahbi Tariq , Basri Hazlami Fikri , Ong Dominic Ek Leong , Muda Khalida , Ojuri Oluwapelumi Olumide , Flores Diana Jumbo , Ammami Mohamed Tahar
Published: October 2024

Microbial-induced carbonate precipitation (MICP) is a promising bioremediation technology for heavy metal immobilisation. This review explores the applications and efficacy of MICP in environmental challenges. It provides a comprehensive overview of the mechanism, primarily through ureolysis, detailing the process from urea hydrolysis to heavy metal precipitation as carbonate minerals. Alternative pathways such as photosynthesis and nitrate reduction are also discussed, highlighting the broad applicability of MICP. The review covers the historical evolution and advancements of MICP as a sustainable solution for heavy metal contamination. Recent studies demonstrate the efficiency of MICP in achieving high removal rates in diverse environments. The sustainable operation, precise targeting of heavy metal species, and versatility of MICP are examined. Challenges such as high copper concentrations, acidic conditions, and cost considerations are addressed. The article provides future directions and solutions to these challenges, including leveraging machine learning for optimal performance and enhancing cost considerations through detailed analyses. This review improves understanding of MICP’s potential, provides a valuable resource for researchers in environmental engineering and the built environment, and encourages innovative approaches within these fields.
[Erratum] Brain Imaging and neurostimulation in health and disorders: status report
Authors: Baptista Abrahão Fontes , Casali Adenauer Girardi , Oda Adriana Leico , Okano Alexandre Hideki , Moreira Alexandre , Santos Ana Lúcia Yaeko da Silva , Fernandes Ana Mércia , Fontana Ana Paula , Brunoni André , Fonseca André , Gosling Artur Padão , Boffino Catarina Costa , Tanaka Clarice , De Oliveira Claudia Eunice Neves , Caparelli-Dáquer Egas , De Angelis Elisabete Carrara , Rodrigues Erika de Carvalho , Fraga Francisco , Hazime Fuad Ahmad , Santana Jamille Evelyn , Sato João Ricardo , Da Silva Josie Resende Torres , Goulardins Juliana Barbosa , Valente Julie Azevedo Araújo , Monte-Silva Kátia , Sá Katia Nunes , Valiengo Leandro , Trambaiolli Lucas Remoaldo , Maia Maércio , Da Silva Marcelo Lourenço , Santana Marcus Vinícius , Carthery-Goulart Maria Teresa , Muszkat Mauro , Lee Michael , Parizotto Nivaldo Antonio , Montoya Pedro , Baptista Rachel Fontes , Duarte-Moreira Rafael Jardim , Brito Rodrigo de Mattos , De Oliveira Rogério Adas Ayres , Cury Rubens , Shinjo Samuel Katsuyuki , Lopes Tiago da Silva , Zana Yossi
Published: October 2024

INTRODUCTION: Despite being considered least important for clinical practice in the pyramid of evidence for recommendations, sometimes scientists' expert opinions could help to better understand the summarization of updated publications. OBJECTIVE: To provide a major summarized update about brain imaging and stimulation of the nervous system in health and disease. METHODS: Comprehensive review developed by experts in each subarea of knowledge in neuroimaging and non-invasive stimulation of the nervous system. A team of researchers and clinic experts was invited to present an update on their area of expertise. RESULTS: In basics on brain imaging techniques, we approach general and quantitative electroencephalography, functional magnetic resonance imaging, functional near-infrared spectroscopy, and experimental paradigms in brain imaging studies. Were included associations between transcranial magnetic stimulation and electromyography, electroencephalography, and functional near-infrared stimulation to evaluate brain activity. Furthermore, we showed several actualized central and peripheral neuromodulation techniques. And finally, we presented different clinical and performance uses of non-invasive neuromodulation. CONCLUSION: To our knowledge, this is a major summarized and concentrated update about brain imaging and stimulation that can benefit neuroscience researchers and clinicians from different levels of experience.
PacBio long-read sequencing v1
Authors: A. Popp Nicholas
Published: October 2024

The barcoded library is also sequenced via PacBio long-read sequencing to associate variants with particular barcodes. This allows for the generation of a variant-barcode map along the length of the protein of interest, to which variant scores can be mapped.
Barcode Sequencing by Illumina NGS v1
Authors: A. Popp Nicholas
Published: October 2024

This protocol details the extraction of genomic DNA from cells and barcode sequencing by NGS.
PCR Fragment Generation (for inserts) v1
Authors: Lopez Carolina
Published: October 2024

Protocol to generate inserts by PCR for cloning
Purity sorting HEK293F cells v1
Authors: A. Popp Nicholas
Published: October 2024

This protocol covers the sorting of landing pad cells (HEK293F) for purity prior to starting MultiSTEP experiments. This avoids using cells which have undergone landing pad silencing, and increases the proportion of cells that are recombined during transfection experiments. Cells are sorted on blue fluorescence, as cells which do express the landing pad also express blue fluorescent protein (BFP). Sort ~2 million BFP+ cells and plate in 10 mL with doxycycline and grow up.
Tests of pulse interference from lightning discharges occurring in unmanned aerial vehicle housings made of carbon fibers.
Authors: Szczupak Paweł , Kossowski Tomasz , Szostek Kamil , Szczupak Mateusz
Published: October 2024

The Aim of the study was to determine the effect of a carbon fiber enclosure on overvoltages induced in unmanned aerial vehicle (UAV) circuits. Carbon fiber reinforced polymer (CFRP) is characterized by a heterogeneous structure and a thorough analysis of its impact on the LEMP (Lightning ElectroMagnetic Pulse) protection of UAVs is crucial for the further development of such machines. The shorter the distance, the greater the amplitude of the EMP, the greater the value of the surges. Their maximum value determines the safe zone. This distance can be reduced by using an enclosure that can absorb or dissipate EMP. The tested object was placed between a large capacitor plates, which ensured the uniformity of the field. This article presents new results of tests on the CFRP shielding effectiveness against the electrical component of atmospheric discharge. Using described below method, an increase in the signal amplitude inside the box was achieved in relation to the input signal, thus strengthening it instead of suppressing it.
Radiological evaluation of a calyceal diverticulum presenting with hematuria
Authors: Masino Federica , Montatore Manuela , Eusebi Laura , Gifuni Rossella , Muscatella Gianmichele , Balbino Marina , Sortino Giuseppe , Pitoni Lucia , Guglielmi Giuseppe
Published: October 2024

Calyceal diverticula, also known as pyelogenic cysts, are a relatively uncommon condition, which is usually asymptomatic and incidentally diagnosed during routine imaging. In some cases, they may lead to concerning symptoms such as hematuria and flank pain, mimicking a renal tumor. In this case report, the patient suffered from hematuria that was initially suspected as a renal malignancy but was ultimately attributed to a calyceal diverticulum. The presented case allows evaluating one of the rarest and underestimated causes of hematuria and describes the main imaging features of calyceal diverticula. In particular, ultrasonography, computed tomography urography, dual-energy computed tomography, and magnetic resonance urography were performed. Subsequently, this case report also serves an educational purpose.
A young patient complaining of left scrotal pain diagnosed with testicular ischemia: a potentially fatal consequence of epididymitis
Authors: Montatore Manuela , Balbino Marina , Fascia Giacomo , Tupputi Ruggiero , Masino Federica , Muscatella Gianmichele , Gifuni Rossella , Guglielmi Giuseppe
Published: October 2024

Rare complications of acute epididymitis include ischemia and infarction of the testicles. Both clinically and radiologically, it is challenging to distinguish testicular torsion. In this article we have tried to expand the library of digital images of radiological diagnostic methods used for fast and accurate differential diagnostics. This case emphasizes the significance of a comprehensive radiological assessment and how a multidisciplinary approach is necessary to guarantee an accurate diagnosis. A 24-year-old man experienced severe left testicular pain and came to the hospital 2 weeks later. At the radiology department, he reported that he had for some time painful ejaculations, pain during intercourse (dyspareunia), scrotal redness/swelling, genital inflammation, chills, swollen inguinal lymph nodes, dysuria, and scrotal pain. All diagnostic procedures were performed, first ultrasonography and then magnetic resonance imaging, as required by the urologist. The imaging studies revealed left testicular ischemia, and based on the referred clinical history, a chronic orchid-epididymitis was suspected. Thus, the condition was resolved, not with a left orchidectomy but with medical therapy because the ischemia area was not too large. The patient also had a left varicocele. Images acquired with different magnetic resonance imaging sequences were carefully examined. A rare instance of epididymal orchitis is described as a potentially dangerous complication of epididymitis and must be considered if sudden, severe scrotal pain is experienced to avoid severe consequences. This case can help with optimal patient management and prevent unnecessary interventions.