bluuebunny/crossref_metadata_2025 huggingface dataset:
Sendai virus C protein limits NO production in infected RAW264.7 macrophages
Authors: Odkhuu Erdenezaya , Komatsu Takayuki , Koide Naoki , Naiki Yoshikazu , Takeuchi Kenji , Tanaka Yukie , Tsolmongyn Bilegtsaikhan , Jambalganiin Ulziisaikhan , Morita Naoko , Yoshida Tomoaki , Gotoh Bin , Yokochi Takashi
Published: September 2018

To suppress virus multiplication, infected macrophages produce NO. However, it remains unclear how infecting viruses then overcome NO challenge. In the present study, we report the effects of accessory protein C from Sendai virus (SeV), a prototypical paramyxovirus, on NO output. We found that in RAW264.7 murine macrophages, a mutant SeV without C protein (4C(–)) significantly enhanced inducible NO synthase (iNOS) expression and subsequent NO production compared to wild type SeV (wtSeV). SeV 4C(-) infection caused marked production of IFN-β, which is involved in induction of iNOS expression via the JAK-STAT pathway. Addition of anti-IFN-β Ab, however, resulted in only marginal suppression of NO production. In contrast, NF-κB, a primarily important factor for transcription of the iNOS gene, was also activated by 4C(–) infection but not wtSeV infection. Induction of NO production and iNOS expression by 4C(–) was significantly suppressed in cells constitutively expressing influenza virus NS1 protein that can sequester double-stranded (ds)RNA, which triggers activation of signaling pathways leading to activation of NF-κB and IRF3. Therefore, C protein appears to suppress NF-κB activation to inhibit iNOS expression and subsequent NO production, possibly by limiting dsRNA generation in the context of viral infection.
Appetite for destruction: Günther Anders and the metabolism of nuclear techno-politics
Authors: van Munster Rens , Sylvest Casper
Published: September 2018

It is well recognized how the modern social sciences, particularly in the United States, fed off and contributed to a nuclear state associated with the military-industrial complex. But it is less known that the thermonuclear revolution also constituted a productive moment for critical theories of (nuclear) techno-politics. In this article, we recover a strand of the latter by focusing on Günther Anders (1902–1992), a German philosopher of technology for whom thermonuclear weapons symbolized the self-destructive capacity embedded in a disenchanted modernity. We stress the techno-political dimensions of Anders’ philosophy by approaching it through his concept and metaphor of metabolism. Anders sought to update Marxist thinking to the age of technology to reawaken his readers to the realities and power dynamics of the nuclear condition and the ways in which these were consistently obscured. He pondered the grotesque human ability to live with a monstrous and suicidal weapon, while highlighting the dynamics of extraction and consumption that characterized both modern ‘mass’ society and nuclear techno-politics. Anders’ quest for emancipation focused on a nurturing of the imagination of modern human beings. We stress the critical, global and activist orientation of his analysis and discuss its merits and contemporary relevance.
A new “nuclear normalcy”?
Authors: Schmid Sonja D
Published: September 2018

This article focuses on a part of the “nuclear condition” that is often overlooked in philosophical discussions: that of materiality. Connecting the spheres of nuclear weapons (and associated security threats), and of nuclear power generation (and associated safety concerns), are the materials that bombs and electricity can be made of, and the machines that produce either enriched uranium or plutonium. We now have evidence of just how fragile the machines and devices were (and are) that sustained the nuclear age, but also how tenuous and artificial the boundary is that we assume between “peaceful” and “military” purposes. And yet, each new “nuclear deal” affirms this boundary, and the possibility of its existence. While the community of scholars and policymakers who prioritize nuclear security strive to label as many steps of the process as “special,” and therefore subject to inspection, accounting, and international control, multinational power companies and national nuclear industries promote “technical fixes” for lingering safety concerns, and advance the opposite strategy: to “normalize” many processes to the point of including severe accident response into the industry’s business-as-usual. The article argues that different kinds of “nuclearities” have increasingly become accepted as “normal”: on one hand, international diplomacy that foregrounds legal and regulatory strategies to nip potential nuclear weapons programs in the bud, and on the other, national nuclear power programs growing their fleets and attempting to expand their market reach. By accepting the divide between the “security community” and the “safety community” as the new “nuclear normalcy,” the shared nuclear materiality threatens to slip out of view, or at the very least, out of focus.
The role of secukinumab in the treatment of psoriatic arthritis and ankylosing spondylitis
Authors: Garcia-Montoya Leticia , Marzo-Ortega Helena
Published: September 2018

Psoriatic arthritis and ankylosing spondylitis are chronic inflammatory diseases that can cause significant disability. The commercialization of the first tumour necrosis factor (TNF) inhibitors led to a radical improvement of the quality of life of people affected by these conditions; however, response was not universal, highlighting the need for alternative therapeutic targets. Secukinumab is a monoclonal interleukin (IL)-17A inhibitor which has been proven efficacious for psoriatic arthritis and ankylosing spondylitis in recent clinical trials. Dactylitis, enthesitis, skin and nails are some of the domains in which the inhibition of IL-17 has shown significant improvements apart from the joints. Its safety profile and satisfactory medium- to long-term outcome data are some of the aspects suggesting its potential impact in treatment protocols in the short term.
How to gamify?: Example scenarios for participation in synchronous online learning
Authors: Çakiroğlu Ünal , Kiliç Servet
Published: September 2018

Participation in synchronous online learning is an increasing need for students’ learning outcomes. Teachers generally cannot be sure about the fact that students who are seen in the participation lists are really following the online tasks. Recent studies have shown that gamification can be an effective way to support learners’ participation in the tasks. This study intended to suggest sample scenarios in line with using gamification elements in online learning environments. Two basic scenarios were developed considering the properties of online learners’ characteristics and gamification elements. First scenario giving learning responsibilities to the learners includes a puzzle activity. Second scenario presents a block-building activity including the leaderboards. The suggested model includes some new ways of using awards, reputation, badges, levels, and leader boards to provide an attractive learning environment. It is hoped that suggested scenarios can provide learning opportunities via increasing participation in synchronous learning environments.
Spine Fractures in Ankylosing Diseases: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU)
Authors: Reinhold Maximilian , Knop Christian , Kneitz Christian , Disch Alexander
Published: September 2018

Study Design:

Review of literature and case series.

Objectives:

Update and review of current treatment concepts for spine fractures in patients with ankylosing spinal disorders.

Methods:

Case presentation and description of a diagnostic and therapeutic algorithm for unstable spinal injuries with an underlying ankylosing spinal disorder (ASD) of the cervical and thoracolumbar spine.

Results:

Nondisplaced fractures can be missed easily using conventional X-rays. Thus, computed tomography (CT) scans are recommended for all trauma patients with ASD. In doubt or presence of any neurologic involvement additional magnetic resonance imaging (MRI) scans should be obtained. Spine precautions should be maintained all times and until definitive treatment (<24 h). Nonoperative fracture treatment is not recommended given the mechanical instability of the most commonly seen fracture patterns (AOSpine B- and C-type, M2) in patients with ASD and inherent high risk of secondary neurologic deterioration. For patients with ankylosing spondylitis (AS) or diffuse idiopathic hyperostosis (DISH) sustaining cervical spine fractures, a combined anterior-posterior instrumentation for fracture fixation is recommended. Closed reduction and patient positioning can be challenging in presence of preexisting kyphotic deformities. In the thoracolumbar (TL) spine, a posterior instrumentation extending 2 to 3 levels above and below the fracture level is recommended to maintain adequate reduction and stability until fracture healing. Minimally invasive percutaneous pedicle screws and cement augmentation can help to minimize the surgical trauma and strengthen the construct stability in patients with diminished minor bone quality (osteopenia, osteoporosis).

Conclusions:

Current concepts, treatment options, and recommendations of the German Orthopedic Trauma Society–Spine Section for spinal fractures in the ankylosed spine have been outlined.
Nonsurgical and Surgical Management of Osteoporotic Vertebral Body Fractures: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU)
Authors: Blattert Thomas R. , Schnake Klaus J. , Gonschorek Oliver , Gercek Erol , Hartmann Frank , Katscher Sebastian , Mörk Sven , Morrison Robert , Müller Michael , Partenheimer Axel , Piltz Stefan , Scherer Michael A. , Ullrich Bernhard W. , Verheyden Akhil , Zimmermann Volker ,   the Spine Section of the German Society for Orthopaedics and Trauma
Published: September 2018

Study Design:

Prospective clinical cohort study (data collection); expert opinion (recommendation development).

Objectives:

Treatment options for nonsurgical and surgical management of osteoporotic vertebral body fractures are widely differing. Based on current literature, the knowledge of the experts, and their classification for osteoporotic fractures (OF classification) the Spine Section of the German Society for Orthopaedics and Trauma has now introduced general treatment recommendations.

Methods:

a total of 707 clinical cases from 16 hospitals were evaluated. An OF classification–based score was developed to guide in the option of nonsurgical versus surgical management. For every classification type, differentiated treatment recommendations were deduced. Diagnostic prerequisites for reproducible treatment recommendations were defined: conventional X-rays with consecutive follow-up images (standing position whenever possible), magnetic resonance imaging, and computed tomography scan. OF classification allows for upgrading of fracture severity during the course of radiographic follow-up. The actual classification type is decisive for the score.

Results:

A score of less than 6 points advocates nonsurgical management; more than 6 points recommend surgical management. The primary goal of treatment is fast and painless mobilization. Because of expected comorbidities in this age group, minimally invasive procedures are being preferred. As a general rule, stability is more important than motion preservation. It is mandatory to restore the physiological loading capacity of the spine. If the patient was in a compensated unbalanced state at the time of fracture, reconstruction of the individual prefracture sagittal profile is sufficient. Instrumentation technique has to account for compromised bone quality. We recommend the use of cement augmentation or high purchase screws. The particular situations of injuries with neurological impairment; necessity to fuse; multiple level fractures; consecutive and adjacent fractures; fractures in ankylosing spondylitis are being addressed separately.

Conclusions:

The therapeutic recommendations presented here provide a reliable and reproducible basis to decide for treatment choices available. However, intermediate clinical situations remain with a score of 6 points allowing for both nonsurgical and surgical options. As a result, individualized treatment decisions may still be necessary. In the next step, the recommendations presented will be further evaluated in a multicenter controlled clinical trial.
Treatment of Fractures of the Thoracolumbar Spine: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU)
Authors: Verheyden Akhil P. , Spiegl Ulrich J. , Ekkerlein Helmut , Gercek Erol , Hauck Stefan , Josten Christoph , Kandziora Frank , Katscher Sebastian , Kobbe Philipp , Knop Christian , Lehmann Wolfgang , Meffert Rainer H. , Müller Christian W. , Partenheimer Axel , Schinkel Christian , Schleicher Philipp , Scholz Matti , Ulrich Christoph , Hoelzl Alexander
Published: September 2018

Study Design:

Abstract consensus paper with systematic literature review.

Objective:

The aim of this study was to establish recommendations for treatment of thoracolumbar spine fractures based on systematic review of current literature and consensus of several spine surgery experts.

Methods:

The project was initiated in September 2008 and published in Germany in 2011. It was redone in 2017 based on systematic literature review, including new AOSpine classification. Members of the expert group were recruited from all over Germany working in hospitals of all levels of care. In total, the consensus process included 9 meetings and 20 hours of video conferences.

Results:

As regards existing studies with highest level of evidence, a clear recommendation regarding treatment (operative vs conservative) or regarding type of surgery (posterior vs anterior vs combined anterior-posterior) cannot be given. Treatment has to be indicated individually based on clinical presentation, general condition of the patient, and radiological parameters. The following specific parameters have to be regarded and are proposed as morphological modifiers in addition to AOSpine classification: sagittal and coronal alignment of spine, degree of vertebral body destruction, stenosis of spinal canal, and intervertebral disc lesion. Meanwhile, the recommendations are used as standard algorithm in many German spine clinics and trauma centers.

Conclusion:

Clinical presentation and general condition of the patient are basic requirements for decision making. Additionally, treatment recommendations offer the physician a standardized, reproducible, and in Germany commonly accepted algorithm based on AOSpine classification and 4 morphological modifiers.
The incidence and distribution of primary fibula tumors and tumor-like lesions: A 35-year experience
Authors: Arikan Yavuz , Misir Abdulhamit , Ozer Devrim , Kizkapan Turan Bilge , Yildiz Kadir Ilker , Saygili Mehmet Selcuk , Incesoy Mustafa Alper , Dincel Yasar Mahsut , Gursu Sukru Sarper , Sahin Vedat
Published: September 2018

Purpose:

Primary bone tumors of the fibula are rare. There are only a few studies reporting the incidence, histologic, and anatomic distribution of primary fibula tumors. This study aimed to comprehensively report the incidence, presenting symptoms, and histologic tumor types with the anatomic and histologic distribution of primary bone tumors of the fibula.

Methods:

Between January 1983 and December 2017, 6457 primary bone tumors and tumor-like lesions were diagnosed and treated in our musculoskeletal oncology surgery clinic. Of these, 264 (4.08%) were primary bone tumors and tumor-like lesions of the fibula. We retrospectively reviewed patients’ records, histopathology records, and radiologic images regarding age, gender, anatomic localization, histopathologic diagnosis, and treatment methods.

Results:

There were 209 (79.2%) benign and 55 (20.8%) malignant lesions. The most common benign and malignant tumors were osteochondroma (51 of 209; 24.4%) and chondrosarcoma (16 of 55; 29.1%). The proximal fibula was the most common location for both benign and malignant tumors (141 of 209; 67.5% and 45 of 55; 81.8%, respectively), followed by the distal fibula (52 of 209; 24.9% and 8 of 55; 14.5%, respectively) and the diaphysis (17 of 209; 8.14% and 2 of 55; 3.64%, respectively).

Conclusion:

The incidence of primary bone tumors is higher than that reported in previous studies. Benign lesions constitute the majority of cases. One-fifth of all cases are malignant. The most common anatomic site involving the primary fibula tumors is the proximal fibula.

Level of evidence:

III.
Tax Evasion and Provision of Public Goods: Implications for Wage and Employment
Authors: Kar Saibal , Banerjee Srijan
Published: September 2018

This exploratory paper analyses, theoretically with some numerical examples, the relationship between tax evasion and provision of public goods. In this model, we incorporate tax evasion leading to a fall in the supply of public goods. We investigate the relation between provision of public goods and wages of workers engaged in the production of public goods and an intermediate private goods. We show that under plausible conditions, and parameter values, fall in the number of taxpayers leads not only to fall in the provision of public goods, but also lowers wages. We find a threshold level of marginal cost associated with supply of public goods, above which the rise in the number of taxpayers may still lower provision of public goods and worker’s wages.

JEL Classifications: H26, H41, E24
Employee Turnover in the Garment Industry in Bangladesh: An Organization-level Perspective
Authors: Hossain Gazi , Mahmood Monowar
Published: September 2018

The main objective of this study is to identify the root causes of employee turnover in the garment industry in Bangladesh. The study employed a combination of case study and documentary research methods. Data and information were collected from eight garment factories through in-depth interviews, reviewing relevant documents, information extracting from annual reports and meetings minutes. The findings reveal wage rates, wage payment methods, training and development, career opportunities and occupational health and safety (OHS) as the main factors leading to high employee turnover in garment factories in Bangladesh. This study further explores the reasons for the variation in employee turnover rates among different garment factories. The findings advocate for a holistic approach adopting “multiple human resource practices” as a bundle to reduce employee turnover in the garment industry. Based on its empirical findings, this study provides recommendations that both corporate managers and government policy makers can follow to reduce employee turnover in the garment industry in Bangladesh.
Urban Slum Morphology and Socio-economic Analogies: A Case Study of Kibera Slum, Nairobi, Kenya
Authors: Mukeku Joseph
Published: September 2018

Narratives around slums tend to amplify their negative attributes, often based on a sensorial assessment of their environment. This article talks about a study carried out in Kibera, the second largest slum in Africa located in Nairobi, Kenya, which examines how slums are morphologically constituted with respect to their socio-economic settings. The study stems from the author’s several years of work as a community design architect on slum upgrading projects, many of which were of a participatory nature. Given that slums exist outside of formal planning and lack documented development records, a basic approach to studying slums was adopted. This article uses analogies to expound on the link between the spatial-temporal formation of the slum and the socio-economic activities and practices of its residents. It goes on to show the crucial need for slum upgrading programmes to pay attention to this strong yet hidden interrelationship in order to meet the needs of the beneficiaries in a sustainable manner.
Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
Authors: Sud Amit , Thomsen Hauke , Orlando Giulia , Försti Asta , Law Philip J. , Broderick Peter , Cooke Rosie , Hariri Fadi , Pastinen Tomi , Easton Douglas F. , Pharoah Paul D. P. , Dunning Alison M. , Peto Julian , Canzian Federico , Eeles Rosalind , Kote-Jarai ZSofia , Muir Kenneth , Pashayan Nora , Campa Daniele ,   the PRACTICAL Consortium, Hoffmann Per , Nöthen Markus M. , Jöckel Karl-Heinz , von Strandmann Elke Pogge , Swerdlow Anthony J. , Engert Andreas , Orr Nick , Hemminki Kari , Houlston Richard S.
Published: September 2018

To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL risk loci at 6p21.31 (rs649775; P = 2.11 × 10−10), 6q23.3 (rs1002658; P = 2.97 × 10−8), 11q23.1 (rs7111520; P = 1.44 × 10−11), 16p11.2 (rs6565176; P = 4.00 × 10−8), and 20q13.12 (rs2425752; P = 2.01 × 10−8). Integration of gene expression, histone modification, and in situ promoter capture Hi-C data at the 5 new and 13 known risk loci implicates dysfunction of the germinal center reaction, disrupted T-cell differentiation and function, and constitutive NF-κB activation as mechanisms of predisposition. These data provide further insights into the genetic susceptibility and biology of HL.
Microenvironmental immune cell signatures dictate clinical outcomes for PTCL-NOS
Authors: Sugio Takeshi , Miyawaki Kohta , Kato Koji , Sasaki Kensuke , Yamada Kyohei , Iqbal Javeed , Miyamoto Toshihiro , Ohshima Koichi , Maeda Takahiro , Miyoshi Hiroaki , Akashi Koichi
Published: September 2018

Key Points

Microenvironmental immune cell signatures stratify PTCL-NOS patients into clinically meaningful disease subtypes. Immune-checkpoint inhibitors represent potential therapeutic options for a PTCL-NOS patient subgroup.
Quantitative prediction of total organic carbon content in shale-gas reservoirs using seismic data: A case study from the Lower Silurian Longmaxi Formation in the Chang Ning gas field of the Sichuan Basin, China
Authors: Chen Sheng , Zhao Wenzhi , Zeng Qingcai , Yang Qing , He Pei , Gai Shaohua , Deng Yu
Published: September 2018

We present a quantitative prediction of total organic carbon (TOC) content for shale-gas development in the Chang Ning gas field of the Sichuan Basin (China). We have used the rock-physics analysis method to define the geophysical characteristics of the reservoir and the most sensitive elastic parameter to TOC content. We established a quantitative prediction template of the TOC content by rock-physics modeling. Well data and 3D seismic data were combined for prestack simultaneous inversion to obtain the most sensitive elastic parameter data volume. According to the prediction template, we transformed the sensitive elastic parameter data volume to the TOC content volume. The rock-physics analysis indicates that the reservoir with a high TOC content in the Lower Silurian Longmaxi Formation (Fm) of the Chang Ning (CN) gas field is characterized by low density, low P-wave velocity ([Formula: see text]), low S-wave velocity ([Formula: see text]), low Poisson’s ratio (PR), and low ratio of P-wave velocity to S-wave velocity ([Formula: see text]). Density is the most sensitive elastic parameter to TOC content. The rock-physics model suggests that density is negatively correlated with TOC content, and the relationship between them changes under different porosities. The reservoir with high TOC content is mainly distributed at the bottom of the Longmaxi Fm and in the central and east central area of the study field. The quantitative prediction results are in good agreement with the log interpretation and production test. Therefore, it has important implications for the efficient development of the shale-gas reservoir in the basin.
Transversus Abdominal Plane Block in Children: Efficacy and Safety: A Randomized Clinical Study and Pharmacokinetic Profile
Authors: Sola Chrystelle , Menacé Cecilia , Bringuier Sophie , Saour Anne-Charlotte , Raux Olivier , Mathieu Olivier , Capdevila Xavier , Dadure Christophe
Published: September 2018

BACKGROUND:

The transversus abdominis plane (TAP) block has become a common regional anesthesia technique for pain management in a wide variety of abdominal procedures. Evidence to support any particular local anesthetic regimen as well as pharmacokinetic and systemic toxicity risks of TAP block remain insufficiently studied in children. The aim of this study was to compare the analgesic effects and investigate pharmacokinetic profile of levobupivacaine after ultrasound-guided TAP block using a low volume/high concentration (LVHC) or a high volume/low concentration (HVLC) solution in children.

METHODS:

This prospective randomized study included children scheduled for day-case inguinal surgery. Children were randomized to receive TAP block using 0.4 mg·kg−1 levobupivacaine as either HVLC (0.2 mL·kg−1 of 0.2% levobupivacaine) or LVHC (0.1 mL·kg−1 of 0.4% levobupivacaine). The primary outcome was the number of children who required opioid rescue analgesia postoperatively. Pharmacokinetic profile study of levobupivacaine was also performed.

RESULTS:

Seventy patients were equally randomized, and 65 were included in the final analysis. Seventy-one percent of patients did not require any postoperative opioid analgesia. The number of patients who received rescue analgesia was 12 (35%) in the LVHC group and 7 (23%) in the HVLC group (relative risk, 0.64; 95% confidence interval [CI], 0.29–1.42; P = .26). Mean pain scores (FLACC [faces, legs, activity, cry, and consolability]) at postanesthesia care unit discharge did not differ between LVHC and HVLC groups, respectively, 0.39 ± 0.86 and 1 ± 1.71 with mean group difference −0.60 (95% CI, −1.27 to 0.06; P = .08). The pharmacokinetic profile of levobupivacaine was comparable in the 2 groups: the mean total and free levobupivacaine peak concentrations were 379 ± 248 and 3.95 ± 3.16 ng·mL−1, respectively, occurring 22.5 ± 11 minutes after injection. The highest total and free levobupivacaine concentrations collected, respectively, 1360 and 15.1 ng·mL−1, remained far below theoretical toxic thresholds.

CONCLUSIONS:

In children, quality of postoperative pain control provided by TAP block using levobupivacaine 0.4 mg·kg−1 administered as either HVLC or LVHC did not differ and was associated with a very low risk of local anesthetic systemic toxicity.
Technicolored
Authors: duCille Ann
Published: September 2018

From early sitcoms such as I Love Lucy to contemporary prime-time dramas like Scandal and How to Get Away with Murder, African Americans on television have too often been asked to portray tired stereotypes of blacks as villains, vixens, victims, and disposable minorities. In Technicolored black feminist critic Ann duCille combines cultural critique with personal reflections on growing up with the new medium of TV to examine how televisual representations of African Americans have changed over the last sixty years. Whether explaining how watching Shirley Temple led her to question her own self-worth or how televisual representation functions as a form of racial profiling, duCille traces the real-life social and political repercussions of the portrayal and presence of African Americans on television. Neither a conventional memoir nor a traditional media study, Technicolored offers one lifelong television watcher's careful, personal, and timely analysis of how television continues to shape notions of race in the American imagination.
Double Negative
Authors: Gates Racquel J.
Published: September 2018

From the antics of Flavor Flav on Flavor of Love to the brazen behavior of the women on Love & Hip Hop, so-called negative images of African Americans are a recurrent mainstay of contemporary American media representations. In Double Negative Racquel J. Gates examines the generative potential of such images, showing how some of the most disreputable representations of black people in popular media can strategically pose questions about blackness, black culture, and American society in ways that more respectable ones cannot. Rather than falling back on claims that negative portrayals hinder black progress, Gates demonstrates how reality shows such as Basketball Wives, comedians like Katt Williams, and movies like Coming to America play on "negative" images to take up questions of assimilation and upward mobility, provide a respite from the demands of respectability, and explore subversive ideas. By using negativity as a framework to illustrate these texts' social and political work as they reverberate across black culture, Gates opens up new lines of inquiry for black cultural studies.
Desire Work
Authors: Hackman Melissa
Published: September 2018

In postapartheid Cape Town—Africa's gay capital—many Pentecostal men turned to "ex-gay" ministries in hopes of “curing” their homosexuality in order to conform to conservative Christian values and African social norms. In Desire Work Melissa Hackman traces the experiences of predominantly white ex-gay men as they attempt to forge a heterosexual masculinity and enter into heterosexual marriage through emotional, bodily, and religious work. These men subjected themselves to daily self-surveillance and followed prescribed behaviors such as changing how they talked and walked. Ex-gay men also saw themselves as participating in the redemption of the nation, because South African society was perceived as suffering from a crisis of masculinity in which the country lacked enough moral heterosexual men. By tying the experience of ex-gay men to the convergence of social movements and public debates surrounding race, violence, religion, and masculinity in South Africa, Hackman offers insights into the construction of personal identities in the context of sexuality and spirituality.
The Macrogenoeconomics of Comparative Development
Authors: Ashraf Quamrul H. , Galor Oded
Published: September 2018

The importance of evolutionary forces for comparative economic performance across societies has been the focus of a vibrant literature, highlighting the roles played by the Neolithic Revolution as well as the prehistoric “out of Africa” migration of anatomically modern humans in generating worldwide variations in the composition of human traits. This essay provides an overview of the literature on the macrogenoeconomics of comparative development, underscoring the significance of evolutionary processes and human population diversity in generating differential paths of economic development across societies. Furthermore, it examines the contribution of Nicholas Wade’s recent hypothesis, regarding the evolutionary origins of comparative development, to this important line of research. ( JEL N10, N30, O11, Z10)
Transparency, Reproducibility, and the Credibility of Economics Research
Authors: Christensen Garret , Miguel Edward
Published: September 2018

There is growing interest in enhancing research transparency and reproducibility in economics and other scientific fields. We survey existing work on these topics within economics and discuss the evidence suggesting that publication bias, inability to replicate, and specification searching remain widespread in the discipline. We next discuss recent progress in this area, including through improved research design, study registration and pre-analysis plans, disclosure standards, and open sharing of data and materials, drawing on experiences in both economics and other social sciences. We discuss areas where consensus is emerging on new practices, as well as approaches that remain controversial, and speculate about the most effective ways to make economics research more credible in the future. ( JEL A11, C18, I23)
Recent advances in understanding and managing infantile colic
Authors: Daelemans Siel , Peeters Linde , Hauser Bruno , Vandenplas Yvan
Published: September 2018

A newborn brings joy to the family. Crying belongs to the spectrum of normal behaviour of young infants. However, although it occurs in about 20% of all infants, unsoothable and persistent crying in young infants distresses the family, although it is usually benign. The aetiology of infantile colic remains unknown, although an unbalanced gastro-intestinal microbiome, increased intestinal permeability, and chronic inflammation are involved, as well as behavioural factors, including over- and under-stimulation. It is a challenge for healthcare professionals to decide when organic disease needs to be excluded. Parental stress is a reason for babies to cry more, inducing a vicious cycle. Therefore, parental reassurance with explanatory guidance is the cornerstone of management. The placebo effect is estimated to be as high as 50%. If an intervention is felt to be necessary to offer further support to the baby and family, it is important to choose the options for which there is some efficacy without adverse effects. There is evidence that some specific probiotic strains such asLactobacillus reuteriDSM 19378, especially in breastfed infants, are effective. However, there are also promising data for some synbiotics and/or killed or tyndallized bacteria, as well as substances decreasing intestinal permeability. Formula management with extensive and/or partial hydrolysates may also bring relief. But, above all, offering parental support remains imperative.
Recent advances in the understanding and management of mucormycosis
Authors: Pilmis Benoit , Alanio Alexandre , Lortholary Olivier , Lanternier Fanny
Published: September 2018

Mucormycoses were difficult-to-manage infections owing to limited diagnostic tools and therapeutic options. We review here advances in pathology understanding, diagnostic tools including computed tomography, and serum polymerase chain reaction and therapeutic options.
Distal middle cerebral artery occlusion does not result in depression-like behaviours
Authors: Couch Yvonne , Clausen Bettina Hjelm , Ormhøj Maria , Andersen Maria Gammelstrup , Kring Christine , Møller Maja , Lambertsen Kate Lykke
Published: September 2018

Background:Stroke is a devastating neurological injury, which can result in significant cognitive and behavioural deficits. Modelling the disease processes associated with stroke in animals is key to the development of novel therapeutic approaches. However, some aspects of stroke pathophysiology, including neuropsychiatric symptoms, do not translate well from humans to animals. Here, we aimed to investigate the development of post-stroke depression in a rodent model of stroke.

Methods:The distal middle cerebral artery (MCA) was permanently occluded by electrocoagulation in adult male C57/Bl6/J mice. Animals were allowed to survive for 6 hours, 24 hours, 2 days, 5 days or 7 days prior to behavioural testing. Brains were taken to confirm lesion volumes at the above times. Behavioural tests studied basic exploration and motivation (open field and marble burying) as well as depression-like behaviours (tail suspension and sucrose preference).

Results:Animals developed robust and reproducible lesions in the cortex but whilst stroke reduced activity in the open field, animals showed no associated behavioural deficits in any of the tests used for depression-like behaviours.

Conclusions:The distal middle cerebral artery occlusion (MCAO) model results in a small cortical lesion which produces no depression-like behaviours. These negative data are important for those wishing to investigate the more cognitive and behavioural aspects of stroke.
ANALYSIS OF FACTORS-FACTORS FECTING THE PERFORMANCE OF ACCOUNTING INFORMATION SYSTEMS IN. BPR SHINTA PUTRA PENGASIH KULON PROG
Authors: Kurniawan Fauzi , Imron Moch
Published: September 2018

This study aims to examine the influence of user participation, user personal techniques, training and education as well as management support on the performance of accounting information systems at PT. BPR Shinta Putra Pengasih. The samples in this study were all employees of PT. BPR Shinta Putra Pengasih working section of marketing, human resources, planning, administration and reporting, and the public. The sample selection was based on purposive sampling by distributing questionnaires. The analysis model used is multiple linear regression. The results show that management support and training and education programs for employees does not affect the performance of accounting information systems, in this case can be seen at a significance level above 0.05 is equal to 0.407 and 0.126. While the personal techniques and user participation affect the performance of accounting information systems, it can be seen from the significant value for the variable and value engineering 0,045 personal significance for variable user participation 0.016. That means the value of the personal significance of variables technique and user participation below 0.05. So the higher the personal techniques and user participation, then the information system performance will increase.
PENGARUH DANA PIHAK KETIGA, MARGIN KEUNTUNGAN, SERTIFIKAT WADIAH BANK INDONESIA, RETURN ON ASSET, DAN NON PERFORMING FINANCING TERHADAP PEMBIAYAAN MURABAHAH PADA BANK SYARIAH MANDIRI DAN BANK MUAMALAT INDONESIA PERIODA 2009-2013
Authors: Amalia Rizqi , Hidayah Khusnul
Published: September 2018

Islamic banks have the same functionality conventional banks as intermediaries of financial services (financial intermediary), has a fundamental duty to collect funds from the public and channeled back to the community in the form of financing facilities. Fund raising is done through savings and investments such, wadiah deposits, savings and time deposits. The distribution of funds is done with some kind of contract as, murabahah, istishna, mudharabah, musyarakah, ijarah, and salam. The purpose of this research is to determine the effect of Third party funds (DPK), profit margin, wadiah certificate of Indonesian Bank (SWBI), return on assets (ROA), and non performing financing (NPF) to murabahah financing. Object in the reserach is Bank Syariah Mandiri and Bank Muamalat Indonesia period 2009-2013. The result of analysis showed by simultan DPK, profit margin, SWBI, ROA, and NPF effect to murabahah financing. Predictive ability of the five variables to financing is 98.7% which is indicated by the amount of adjusted R2 and the rest is influenced by other variables. DPK, and ROA partially positive effect to murabahah financing. SWBI negatively affect to murabahah financing. The profit margin is not a positive influence to murabahah financing and NPF does not negative affect to murabahah financing.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI TINGKAT KEPATUHAN PAJAK WAJIB PAJAK BADAN PADA PERUSAHAAN INDUSTRI MANUFAKTUR DI DAERAH ISTIMEWA YOGYAKARTA
Authors: Irawan Didik , Ariesanti Alia
Published: September 2018

The purpose of the research is to analyze the behavior of tax compliance of corporate taxpayers, particularly large industrial manufacturing company that exists through out Daerah Istimewa Yogyakarta, represented by professional tax who work at the company. The results of this study indicate that: (1) the strength or weakness of a professional tax attitude does not affect the level of tax compliance in a corporate entity, (2) subjective norm has no effect on the level of corporate tax compliance, (3) strong or weak moral obligation of professional tax does not affect the level of tax compliance in a corporate entity, (4) the strength or weakness of a professional tax intention to behave not affect the level of tax compliance in a corporate entity, (5) the company 's financial condition does not affect the level of corporate tax compliance, (6) large or a small facility of company where professional tax work does not affect the level of tax compliance from a corporate entity, (7) organizational climate where professional tax work affects the level of tax compliance from a corporate entity. This study also represents that professional tax do not greatly affect the level of tax compliance in the corporate taxpayers large manufacturing company in Daerah Istimewa Yogyakarta.
PENGARUH KOMITMEN PROFESIONAL, KOMITMEN ORGANISASIONAL, DAN BUDAYA ORGANISASI TERHADAP KEPUASAN KERJA AKUNTAN PENDIDIK, STUDI KASUS PADA UNIVERSITAS DI YOGYAKARTA
Authors: Wulandari Yuni , Sumaryanto Sumaryanto
Published: September 2018

The purpose of this research examines for the influences of professional commitment, organizational commitment, and organization culture to the satisfaction of work. The population of this research are the educationalist accountants (the lecturers who have an accountant professional’s degree) from some of universities in Yogyakarta. This research takes samples by using quizioner. The technique of sample’s taking use purposive sampling for the population that has been chosen with responden’s requirement based on those requirement, there are 45 respondents as the sample from 7 universitas in Yogyakarta. Based on the result of analysis, it could be cocluded that the professional commitment and organizational commitment do not give influence to the work;s satisfaction of educatinalist accountants. Otherwise, the organization culture give influence to the work’s satisfaction of educationalist accountants.
FAKTOR-FAKTOR PERSEPSI WAJIB PAJAK TERHADAP ETIKA PENGGELAPAN PAJAK
Authors: Surahman Wanda , Putra Ulinnuha Yudiansa
Published: September 2018

This study examines the effect of taxation understanding, subjective norm, love of money and religiousity on taxpayers’ perception on tax evasion ethics. Primary data were obtained through direct survey using questionnaires.  Using multiple regression analysis, four hypotheses were tested. The results show that only two hypotheses are supported revealing that taxation understanding and religiousity have positive effect on taxpayers’ perception on tax evasion ethics.
Cardioprotective whole-diet advice in cardiac rehabilitation
Authors: Parker Tracy , Taylor Victoria
Published: September 2018

Seven out of ten people are surviving a heart attack. Good quality cardiac rehabilitation with dietary advice as a core component is a vital part of the management of these patients. In the past, cardiac rehabilitation advice focused on single risk factors and nutrients, such as fats and lipid modification. However, as knowledge about nutrition and cardiovascular disease (CVD) has grown, it has become clear that there is a much broader role for dietary change; advice must focus on the diet as a whole and the balance of food within it, to reduce CVD risk. Despite this, much of the debate around nutrition and the cardiac patient continues to focus on individual foods or risk factors. This can detract from the advice given to patients in national guidelines on a whole-diet approach. The traditional Mediterranean diet is recommended consistently across national guidelines and is one of the most well-researched dietary patterns. This approach has been associated with a lower risk of CVD; however, other models, including the ‘dietary approaches to stop hypertension’ (DASH) diet, have also been found to be successful.
The homoerotics of the boyband, queerbaiting and RPF in pop music fandoms
Authors: Roach Emily E.
Published: September 2018

This article analyses pop music fandoms, exploring the relationship between LGBT communities and popular music, the homoerotics of the nineties boyband, Nick Jonas and performative allyship, the phenomenon of One Direction and related slash ship, Larry Stylinson and the queer appeal of solo artist and former One Direction member, Harry Styles. Through these examples, this article explores the trends towards marketing and styling boybands with an eye towards homosexual men and heterosexual teenage girls and/or a large fandom producing queer works of ‘Real Person Fiction’. This article interrogates the perilous line between being baited for economic gain and the transformative possibilities of queer coded pop and homoerotic subtext, which can have an affirmational impact on queer fans. It considers the problems with making incomplete assumptions about fandom demographics and draws out complexities involved when real lives and sexualities are at the forefront of anti-queerbaiting rhetoric and fan activism takes a toxic turn. The article explains why ‘queerbaiting’, as the term has been broadly defined in relation to fictional narratives, is not quite the right terminology to use when interrogating the behaviour of pop stars and their interactions with the fandoms built around them.
Slashbaiting, an alternative to queerbaiting
Authors: Brennan Joseph
Published: September 2018

This article analyses discourse on gay and lesbian Internet forum DataLounge that discusses homoeroticism in the BBC’s Merlin. Merlin is a cult series that is commonly associated with the ‘queerbaiting’ phenomenon, a fan activist term that criticizes unrealized homoerotic suggestiveness in mainstream texts. Textual analysis is performed on seven relevant threads created between 2009 and 2012, which have attracted in excess of 700 responses. The threads were authored by predominately gay men and align with the airing of the series, commentators posting in real time. Focus is given in the analysis to discussion of homoeroticism in the text, in particular on how this homoeroticism is interpreted by viewers. Notably, across this sample, homoeroticism in Merlin is discussed in a celebratory way, with no mention of queerbaiting or the exploitative connotations that underscore the term. In fact, such homoeroticism is routinely described as a form of ‘fan service’ across the sample. The study provides empirical evidence that a sizeable proportion of the Merlin viewership (gay men) have a more ‘playful’ approach to the queerbaiting phenomenon. The discourse also supports the coining of a new term, ‘slashbaiting’, which is in line with a view of homoeroticism in contemporary media as a form of fan service, in particular for slash fans.
Development of Masterplan and Initial Program for Food Security in Papua Region, Indonesia
Authors: Pertiwiningrum Ambar , Agus Cahyono , Supriadi Supriadi , Supriyanta Supriyanta , Agus Ali , Napitupulu Richard P , Soeherman Yudistira
Published: September 2018

Food Security and Vulnerability Atlas (FSVA) of Indonesia 2015 categorized the vulnerability to food and nutrition insecurity based on nine indicators covering food availability, food access and food utilization. According to the assessment, 14 districts in priority 1 (severely vulnerable to food insecurity) were all in Papua. Responding to the problems of food insecurity, a multi-year program focusing on two regencies, i.e., Manokwari and Merauke, was conducted from August 2015. The program was developed in cooperation with the Ministry of Villages, Disadvantaged Regions and Transmigration (Kemendes PDTT), Gadjah Mada University Yogyakarta and district governments. This research aimed to examine the problems causing food insecurity and to develop integrative and collaborative macro-scale policy recommendations. The study used a qualitative descriptive method and a pilot project approach to address food insecurity problems in both regencies. It found five main issues related to food insecurity in Papua: the prevalence of stunting among children under five, the ratio of per capita normative consumption towards net cereal production, the population living below poverty line, households without access to clean water, and low-income families. The problems could be overcome by concerning the ratio of normative consumption per capita and the preservation of local food, and local crops should be grown especially tubers. Regarding the problems associated with low-income families, a program that should be implemented is the welfare improvement of the rural low-income families through the optimization of land resources in the integrated and intensive ways in response to many land resources still underutilized. Moreover, water treatment should be encouraged further to tackle clean water issues.