bluuebunny/crossref_metadata_2025 huggingface dataset:
Unravelling the Impact of Grape Washing, SO2, and Multi-Starter Inoculation in Lab-Scale Vinification Trials of Withered Black Grapes
Authors: Checchia Ilaria , Binati Renato L. , Troiano Eleonora , Ugliano Maurizio , Felis Giovanna E. , Torriani Sandra
Published: March 2021

Wine quality is strongly affected by chemical composition and microbial population of grape must, which, in turn, are influenced by several post-harvest treatments, including grape withering. Different strategies have been suggested to manage the fermenting must microbiota, as it plays a central role in the outcomes of both spontaneous and guided fermentations. This study aimed at evaluating the impact of grape washing, SO2 addition, and selected starter culture inoculation on population dynamics, fermentation kinetics, and main oenological parameters in lab-scale trials, focusing on withered grapes usually used for Amarone production. Although grape washing treatment was effective in removing heavy metals and undesirable microorganisms from grape berry surface, inoculation of multi-starter cultures impacted more fermentation rates. Further, both grape washing and starter inoculation procedures had a remarkable impact on wine chemical characteristics, while 30 mg/L SO2 addition did not significantly affect the fermentation process. In summary, the best strategy in terms of limiting off-flavors and potentially reducing the need for SO2 addition in wine from withered grapes was the use of yeast starters, particularly mixed cultures composed by selected strains of Metschnikowia spp. and Saccharomyces cerevisiae. Application of a washing step before winemaking showed a potential to improve organoleptic characteristics of wine.
Simulating and Evaluating a Real-World ElasticSearch System Using the RECAP DES Simulator
Authors: Bendechache Malika , Svorobej Sergej , Endo Patricia Takako , Mihai Adrian , Lynn Theo
Published: March 2021

Simulation has become an indispensable technique for modelling and evaluating the performance of large-scale systems efficiently and at a relatively low cost. ElasticSearch (ES) is one of the most popular open source large-scale distributed data indexing systems worldwide. In this paper, we use the RECAP Discrete Event Simulator (DES) simulator, an extension of CloudSimPlus, to model and evaluate the performance of a real-world cloud-based ES deployment by an Irish small and medium-sized enterprise (SME), Opening.io. Following simulation experiments that explored how much query traffic the existing Opening.io architecture could cater for before performance degradation, a revised architecture was proposed, adding a new virtual machine in order to dissolve the bottleneck. The simulation results suggest that the proposed improved architecture can handle significantly larger query traffic (about 71% more) than the current architecture used by Opening.io. The results also suggest that the RECAP DES simulator is suitable for simulating ES systems and can help companies to understand their infrastructure bottlenecks under various traffic scenarios and inform optimisation and scalability decisions.
Use of Invasive Green Crab Carcinus maenas for Production of a Fermented Condiment
Authors: Greiner Delaney M. , Skonberg Denise I. , Perkins Lewis B. , Perry Jennifer J.
Published: March 2021

To control the population of an invasive species of green crab, we investigated the feasibility of producing a fermented crab condiment. Commercial fermented fish condiments were tested to assess variability in the marketplace and to identify targets for lab-fermented sauces. Finely chopped crab was combined with 100 mg g−1, 200 mg g−1, or 300 mg g−1 NaCl, and spontaneously fermented for up to 120 days. Chromatographic analysis revealed that histamine content was not a safety concern as all treatments were below the current U.S. legal threshold (50 mg 100 mL−1). The majority of microbial and physicochemical properties measured within salt level (proteolytic bacterial population, total volatile basic nitrogen (TVBN), amine nitrogen, water activity, moisture, and biogenic amines) were statistically unchanged between days 60 and 120 of fermentation, suggesting that most of the biochemical changes happened early in the fermentation. While the production of a fermented condiment was successful and could represent an opportunity for the valorization of this invasive species, additional work is needed to accelerate the process and further understand the dynamics of the early fermentation stages.
Protocol for Designing New Functional Food with the Addition of Food Industry By-Products, Using Design Thinking Techniques—A Case Study of a Snack with Antioxidant Properties for Physically Active People
Authors: Tkaczewska Joanna , Kulawik Piotr , Morawska-Tota Małgorzata , Zając Marzena , Guzik Paulina , Tota Łukasz , Pająk Paulina , Duliński Robert , Florkiewicz Adam , Migdał Władysław
Published: March 2021

The aim of the work was to develop an easy-to-follow protocol for designing novel functional products with the addition of food industry by-products using design thinking techniques. As a result, a 12-step protocol has been designed and presented. The protocol consists of steps from the initial formation of the design team, through all the stages of the production and prototyping, until establishing the final storage conditions and creating final documentation. The protocol has been validated and explained using a case study in which a fish industry by-product hydrolysate with bioactive properties was used to develop a novel functional food product for physically active people: a date bar with carp meat and carp skin gelatin hydrolysate. Following the 12 steps presented in the protocol resulted in developing a food product with high nutritional value and antioxidant power which remains stable during storage at reduced temperatures. Moreover, the product is characterized by good sensory qualities and can be easily implemented into full-scale production. The newly designed protocol is an easy-to-follow method that could be used in almost any kind of food industry sector to sucesfully develop user-focused functional food products with by-product addition.
Evidence Supporting the Regulatory Relationships through a Paracrine Pathway between the Sternum and Pectoral Muscles in Ducks
Authors: Li Yanying , Liu Hehe , Wang Lei , Xi Yang , Wang Jiwen , Zhang Rongping , Li Liang , Bai Lili , Mustafa Ahsan
Published: March 2021

Muscles and bones are anatomically closely linked, and they can conduct communication by mechanical and chemical signals. However, the specific regulatory mechanism between the pectoral muscle and sternum in birds was largely unknown. The present study explored the potential relationship between them in ducks. The result of the sections showed that more nuclei in proliferate states were observed in the pectoral muscle fibers attached to the calcified sternum, than those attached to the un-calcified sternum. The RNA-seq identified 328 differentially expressed genes (DEGs) in the sternum between the calcified and un-calcified groups. Gene ontology (GO) showed that the DEGs were mainly enriched in pathways associated with calcification. In addition, DEGs in the muscles between the calcified and un-calcified sternum groups were mainly annotated to signal transduction receptor pathways. The expression patterns of genes encoding for secreted proteins, in bone (CXCL12, BMP7 and CTSK) and muscle (LGI1), were clustered with muscle development (MB) and bone calcification (KCNA1, OSTN, COL9A3, and DCN) related genes, respectively, indicating the regulatory relationships through a paracrine pathway existing between the sternum and pectoral muscles in ducks. Together, we demonstrated that the pectoral muscle development was affected by the sternal ossification states in ducks. The VEGFA, CXCL12, SPP1, NOG, and BMP7 were possibly the key genes to participate in the ossification of the duck sternum. We firstly listed evidence supporting the regulatory relationships through a paracrine pathway between the sternum and pectoral muscles in ducks, which provided scientific data for the study of the synergistic development of bone and skeletal muscle.
Field Observations of a Multilevel Beach Cusp System and Their Swash Zone Dynamics
Authors: Nuyts Siegmund , Li Zili , Hickey Kieran , Murphy Jimmy
Published: March 2021

This paper presents the observed morphological evolution of a multilevel beach cusp system in Long Strand, Co. Cork, Ireland. The surveys were carried out with an Unmanned Aerial Vehicle (UAV) system between March and September 2019. From this site, three levels of beach cusps on the beachface (i.e., lower beach level, mid beach level and upper beach level), and critical cusp parameters are reported, including cusp spacing, cusp elevation, cusp depth, and cusp amplitude. Thus far, such an extensive dataset has not previously been reported in the literature from a single site. The evolution of the different cusp parameters is then linked with the hydrodynamics in the study area, and new prediction theories are proposed for the different cusp parameters. The Lower beach level cusps (1 < z < 2.5 m Irish Transverse Mercator (ITM)) changed with every tide and appeared when surf-similarity parameter-ξ0 < 1.55. These cusps had a mean cusp spacing of λmean = 11.09 m, which are closely linked with the predictions of the self-organisation theory (p < 0.05). In contrast, the Mid beach level cusps (2.5 < z < 3.5 m ITM) are less dynamic compared to the Lower beach level cusps and can persist between spring tidal cycles. They had a mean cusp spacing of λmean = 18.17 m. The Upper beach level cusps (approximately z = 6 m ITM) are above astronomical tide levels and have a mean cusp spacing of λmean = 40.26 m. They did not change significantly over the survey period due to a lack of major storm events. These findings give a better understanding of the evolution of different cusp parameters for a multilevel beach cusp system and can be used to formulate a global theory regarding their change over time.
Clinical Impact of Sarcopenia on Gastrointestinal Tumors
Authors: Pereira Ana , Pereira Joaquim Costa , Martins Sandra F.
Published: March 2021

Preoperative risk stratification in cancer surgery is important to improve treatment and outcome. Sarcopenia is defined by progressive and generalized loss of skeletal muscle mass and strength and is now getting attention as a poor prognostic factor. The purpose of this review was to explore the impact of sarcopenia on short and long-term outcomes in patients undergoing surgical resection of gastrointestinal tumors. Recent studies suggest that sarcopenia contributes to postoperative complications and overall survival. The relatively simple evaluability, as well as its modifiable nature, provides an intriguing potential for sarcopenia to be included in standard preoperative clinical evaluation. Such evaluations can provide physicians with important information to target high-risk individuals with prophylactic measures and eventually improve surgical outcomes.
Molecular Basis of Atrial Fibrillation Initiation and Maintenance
Authors: Beneke Kira , Molina Cristina E.
Published: March 2021

Atrial fibrillation (AF) is the most common cardiac arrhythmia, largely associated to morbidity and mortality. Over the past decades, research in appearance and progression of this arrhythmia have turned into significant advances in its management. However, the incidence of AF continues to increase with the aging of the population and many important fundamental and translational underlaying mechanisms remain elusive. Here, we review recent advances in molecular and cellular basis for AF initiation, maintenance and progression. We first provide an overview of the basic molecular and electrophysiological mechanisms that lead and characterize AF. Next, we discuss the upstream regulatory factors conducting the underlying mechanisms which drive electrical and structural AF-associated remodeling, including genetic factors (risk variants associated to AF as transcriptional regulators and genetic changes associated to AF), neurohormonal regulation (i.e., cAMP) and oxidative stress imbalance (cGMP and mitochondrial dysfunction). Finally, we discuss the potential therapeutic implications of those findings, the knowledge gaps and consider future approaches to improve clinical management.
Detecting and Treating Psychosocial and Lifestyle-Related Difficulties in Chronic Disease: Development and Treatment Protocol of the E-GOAL eHealth Care Pathway
Authors: Cardol Cinderella K. , Tommel Judith , van Middendorp Henriët , Ciere Yvette , Sont Jacob K. , Evers Andrea W. M. , van Dijk Sandra
Published: March 2021

Many patients with lifestyle-related chronic diseases find it difficult to adhere to a healthy and active lifestyle, often due to psychosocial difficulties. The aim of the current study was to develop an eHealth care pathway aimed at detecting and treating psychosocial and lifestyle-related difficulties that fits the needs and preferences of individual patients across various lifestyle-related chronic diseases. Each intervention component was developed by (1) developing initial versions based on scientific evidence and/or the Behavior Change Wheel; (2) co-creation: acquiring feedback from patients and health professionals; and (3) refining to address users’ needs. In the final eHealth care pathway, patients complete brief online screening questionnaires to detect psychosocial and lifestyle-related difficulties, i.e., increased-risk profiles. Scores are visualized in personal profile charts. Patients with increased-risk profiles receive complementary questionnaires to tailor a 3-month guided web-based cognitive behavioral therapy intervention to their priorities and goals. Progress is assessed with the screening tool. This systematic development process with a theory-based framework and co-creation methods resulted in a personalized eHealth care pathway that aids patients to overcome psychosocial barriers and adopt a healthy lifestyle. Prior to implementation in healthcare, randomized controlled trials will be conducted to evaluate its cost-effectiveness and effectiveness on psychosocial, lifestyle, and health-related outcomes.
Orthodontic Treatment and Craniocervical Posture in Patients with Temporomandibular Disorders: An Observational Study
Authors: Paço Maria , Duarte José Alberto , Pinho Teresa
Published: March 2021

Orthodontic treatment acts through the application of forces and/or by stimulating and redirecting the functional forces within the craniofacial complex. Considering the interrelationship between craniomandibular and craniocervical systems, this intervention may alter craniocervical posture. Thus, our aim is to (a) compare craniocervical posture, hyoid bone position, and craniofacial morphology before, after, and also in the contention phase at least one year after the orthodontic treatment, in patients with temporomandibular disorders and (b) to verify whether the presence of condylar displacement, the skeletal class, or the facial biotype interferes with the abovementioned outcomes. To do so an observational, analytical, longitudinal, and retrospective design study was carried out. A non-probabilistic convenience sampling method was applied. The sample consisted of clinical records of patients diagnosed with temporomandibular disorders in order to compare pre-orthodontic treatment with post-orthodontic treatment (n = 42) and contention phase data (n = 26). A cephalometric analysis of several variables was performed. The p-value was set as 0.05. When the pre- and post-orthodontic treatment data were analyzed, there were statistically significant changes in variables concerning craniocervical posture (CV angle, C0-C1, and AA-PNS) and also concerning hyoid bone position (C3-Rgn). When pre- and post-orthodontic treatment and contention phase data were analyzed the variables concerning craniocervical posture (C0-C1, CVT/Ver, NSL/OPT, NSL/CVT, NSL/Ver; OPT/CVT, OPT/Ver) and facial biotype had statistically significant changes. This allowed us to conclude that in the sample studied, there were significant differences regarding hyoid bone position (pre- versus post-orthodontic treatment) and craniocervical posture (pre- versus post-orthodontic versus contention), with the craniocervical posture being prone to return to basal values. The presence of condylar displacement was found to significantly increase the H-H1 distance in the three moments of evaluation. Facial biotype was found to significantly increase the NSL/Ver angle on hypodivergent compared to hyperdivergent in the contention phase.
Associations between Greenspace and Gentrification-Related Sociodemographic and Housing Cost Changes in Major Metropolitan Areas across the United States
Authors: Schinasi Leah H. , Cole Helen V. S. , Hirsch Jana A. , Hamra Ghassan B. , Gullon Pedro , Bayer Felicia , Melly Steven J. , Neckerman Kathryn M. , Clougherty Jane E. , Lovasi Gina S.
Published: March 2021

Neighborhood greenspace may attract new residents and lead to sociodemographic or housing cost changes. We estimated relationships between greenspace and gentrification-related changes in the 43 largest metropolitan statistical areas (MSAs) of the United States (US). We used the US National Land Cover and Brown University Longitudinal Tracts databases, as well as spatial lag models, to estimate census tract-level associations between percentage greenspace (years 1990, 2000) and subsequent changes (1990–2000, 2000–2010) in percentage college-educated, percentage working professional jobs, race/ethnic composition, household income, percentage living in poverty, household rent, and home value. We also investigated effect modification by racial/ethnic composition. We ran models for each MSA and time period and used random-effects meta-analyses to derive summary estimates for each period. Estimates were modest in magnitude and heterogeneous across MSAs. After adjusting for census-tract level population density in 1990, compared to tracts with low percentage greenspace in 1992 (defined as ≤50th percentile of the MSA-specific distribution in 1992), those with high percentage greenspace (defined as >75th percentile of the MSA-specific distribution) experienced higher 1990–2000 increases in percentage of the employed civilian aged 16+ population working professional jobs (β: 0.18, 95% confidence interval (CI): 0.11, 0.26) and in median household income (β: 0.23, 95% CI: 0.15, 0.31). Adjusted estimates for the 2000–2010 period were near the null. We did not observe evidence of effect modification by race/ethnic composition. We observed evidence of modest associations between greenspace and gentrification trends. Further research is needed to explore reasons for heterogeneity and to quantify health implications.
The Association between Bone Mineral Density and Periodontal Disease in Middle-Aged Adults
Authors: Chou Hsin-Hua , Lu Sao-Lun , Wang Sen-Te , Huang Ting-Hsuan , Chen Sam Li-Sheng
Published: March 2021

The association between osteoporosis and periodontal disease (PD) has been revealed by previous studies, but there have been few studies on the association in younger adults. We enrolled a total of 7298 adults aged 40 to 44 who underwent PD screening between 2003 and 2008. Data on quantitative ultrasound for the measurement of bone mineral density (BMD) were collected for the diagnostic criteria of osteopenia and osteoporosis. The Community Periodontal Index (CPI) was measured for defining PD. A multiple logistic regression model was used to assess the effect of low bone mass on the risk of PD. Of 7298 enrollees, 31% had periodontal pockets >3 mm, 36.2% had osteopenia, and 2.1% had osteoporosis. The 39.8% of PD prevalence was high in adults with osteoporosis, followed by 33.3% in osteopenia. A negative association was found between BMD and CPI value (p < 0.0001). Low bone mass was associated with the risk of PD (adjusted OR: 1.13; 95% CI:1.02–1.26) after adjusting the confounding factors, including age, gender, education level, overweight, smoking status, past history of osteoporosis, and diabetes mellitus. An association between BMD and PD among young adults was found. An intervention program for the prevention of PD and osteoporosis could be considered starting in young adults.
Investigating Molecular Mechanisms of Immunotoxicity and the Utility of ToxCast for Immunotoxicity Screening of Chemicals Added to Food
Authors: Naidenko Olga V. , Andrews David Q. , Temkin Alexis M. , Stoiber Tasha , Uche Uloma Igara , Evans Sydney , Perrone-Gray Sean
Published: March 2021

The development of high-throughput screening methodologies may decrease the need for laboratory animals for toxicity testing. Here, we investigate the potential of assessing immunotoxicity with high-throughput screening data from the U.S. Environmental Protection Agency ToxCast program. As case studies, we analyzed the most common chemicals added to food as well as per- and polyfluoroalkyl substances (PFAS) shown to migrate to food from packaging materials or processing equipment. The antioxidant preservative tert-butylhydroquinone (TBHQ) showed activity both in ToxCast assays and in classical immunological assays, suggesting that it may affect the immune response in people. From the PFAS group, we identified eight substances that can migrate from food contact materials and have ToxCast data. In epidemiological and toxicological studies, PFAS suppress the immune system and decrease the response to vaccination. However, most PFAS show weak or no activity in immune-related ToxCast assays. This lack of concordance between toxicological and high-throughput data for common PFAS indicates the current limitations of in vitro screening for analyzing immunotoxicity. High-throughput in vitro assays show promise for providing mechanistic data relevant for immune risk assessment. In contrast, the lack of immune-specific activity in the existing high-throughput assays cannot validate the safety of a chemical for the immune system.
Proposal of a New Orange Selection Process Using Sensory Panels and AHP
Authors: Baviera-Puig Amparo , García-Melón Mónica , Ortolá María Dolores , López-Cortés Isabel
Published: March 2021

Although the consumption of fruits and vegetables is being promoted by different institutions as a key question of public health, their consumption is decreasing and their waste is increasing. To address this situation, we propose to include the consumer’s perception of the quality (from a sensory point of view) of a fruit, in particular Valencian oranges, in the supplier’s selection process by retailers. To do so, we use a combination of consumer and trained sensory panels and Analytic Hierarchy Process (AHP). This approach is completely novel in the literature. According to the expert panel, the most important criteria when evaluating the quality of an orange are fruity smell, juiciness, sweetness and acidity. These criteria are related to the freshness and taste of the oranges. Consumers found the methodology proposed useful and easy to develop. The application of the AHP methodology has helped to facilitate a participatory discussion among consumers on the concept of the quality of the oranges. The methodology proposed can help the agrifood sector in different ways up and down the supply chain. Specially, it can contribute to better meet consumer’s demands, increasing the consumption of fruits and vegetables and reducing its waste.
Development and Effects of Cognitive Behavior-Based Healing Programs Using Mobile Apps
Authors: Hwang Won Ju , Jo Hyun Hee
Published: March 2021

Purpose: There has been a recent surge in interest in mental health and how to improve individuals’ health-related quality of life. Mental health management using mobile apps can be a useful intervention method. The development and application of verified and highly efficient apps for mental health and stress management are needed. We developed healing programs and verified their effectiveness based on apps designed to promote adult mental health. Methods: We conducted a one-group pretest-posttest study in which 85 participants used the app for 12 weeks. We assessed its effects on participants’ stress (perceived stress scale, effort–reward imbalance, and photoplethysmogram (PPG)), anxiety, depression, emotional labor, and well-being. Results: The stress survey results post-intervention increased or stayed the same; however, the PPG results decreased (p = 0.002) after using the app. Depression (p = 0.043) and anxiety (p = 0.003) also decreased; however, emotional labor and well-being remained unchanged. The awareness of, knowledge of, and attitude toward mental health management all increased post-intervention. Discussion: The developed mobile app was an efficient and highly accessible way to promote mental health. However, the app requires modification and supplementation for continual use. Additionally, ongoing research concerning the study, evaluation, and integration of mobile apps is required.
Performance Assessment Indicators for Comparing Recreational Services of Urban Parks
Authors: Yang Yang , Wang Zhifang , Lin Guangsi
Published: March 2021

Parks can offer varied services to human well-being, including recreational services (RS); however, there is insufficient understanding of park differences concerning the actual performance of their varied RS. To fill this gap, this study aimed to develop a set of performance indicators as a tool for comparing the functional efficacy of RS among different parks. The indicators covered three aspects of RS: recreational usage of various physical activities, their recreational satisfaction level and the collective performance rating. These indicators were applied in a case study of four parks in Guangzhou, China, based upon on-site observation and a questionnaire survey. The functional difference of these indicators was compared and the collective indicator was found to be able to effectively capture different efficacies of urban parks in supporting varied RS. Results show all the parks were far from reaching the maximum performance of designed RS, so it is worthy of consideration by urban managers to further improve their RS efficacy. In addition, the overall spatial design and configuration were inferred to be essential for improving the RS efficacy of urban parks, but not park size nor ornamental vegetation. The findings offered valuable evidence for the optimal spatial design and management of urban parks.
Understanding the Global Challenges to Accessing Appropriate Wheelchairs: Position Paper
Authors: Gowran Rosemary Joan , Bray Nathan , Goldberg Mary , Rushton Paula , Barhouche Abou Saab Marie , Constantine David , Ghosh Ritu , Pearlman Jonathan
Published: March 2021

Introduction: Appropriate wheelchairs are often essential for the health and wellbeing of people with mobility impairments to enhance fundamental freedoms and equal opportunity. To date, provision has mainly focused on just delivering the wheelchair instead of following an evidence-based wheelchair service delivery process. In addition, many governments have not committed to a national wheelchair provision policy. Approach: To prepare this position paper, a systemic development model, founded on the sustainable human security paradigm, was employed to explore the global challenges to accessing appropriate wheelchairs. Positions: I: Consideration of key perspectives of wheelchair provision across the life course is essential to meet the needs to children, adults, older people and their families; II: Comprehensive wheelchair service delivery processes and a competent workforce are essential to ensure appropriate wheelchair service provision; III: Evaluations on wheelchair product quality development, performance and procurement standards are key as wheelchair product quality is generally poor; IV: Understanding the economic landscape when providing wheelchairs is critical. Wheelchair funding systems vary across jurisdictions; V: Establishing wheelchair provision policy is a key priority, as specific policy is limited globally. Conclusion: The vision is to take positive action to develop appropriate and sustainable wheelchair service provision systems globally, for me, for you, for us.
Which PHQ-9 Items Can Effectively Screen for Suicide? Machine Learning Approaches
Authors: Kim Sunhae , Lee Hye-Kyung , Lee Kounseok
Published: March 2021

(1) Background: The Patient Health Questionnaire-9 (PHQ-9) is a tool that screens patients for depression in primary care settings. In this study, we evaluated the efficacy of PHQ-9 in evaluating suicidal ideation (2) Methods: A total of 8760 completed questionnaires collected from college students were analyzed. The PHQ-9 was scored in combination with and evaluated against four categories (PHQ-2, PHQ-8, PHQ-9, and PHQ-10). Suicidal ideations were evaluated using the Mini-International Neuropsychiatric Interview suicidality module. Analyses used suicide ideation as the dependent variable, and machine learning (ML) algorithms, k-nearest neighbors, linear discriminant analysis (LDA), and random forest. (3) Results: Random forest application using the nine items of the PHQ-9 revealed an excellent area under the curve with a value of 0.841, with 94.3% accuracy. The positive and negative predictive values were 84.95% (95% CI = 76.03–91.52) and 95.54% (95% CI = 94.42–96.48), respectively. (4) Conclusion: This study confirmed that ML algorithms using PHQ-9 in the primary care field are reliably accurate in screening individuals with suicidal ideation.
Bayesian Estimation for Reliability Engineering: Addressing the Influence of Prior Choice
Authors: Leoni Leonardo , BahooToroody Farshad , Khalaj Saeed , Carlo Filippo De , BahooToroody Ahmad , Abaei Mohammad Mahdi
Published: March 2021

Over the last few decades, reliability analysis has attracted significant interest due to its importance in risk and asset integrity management. Meanwhile, Bayesian inference has proven its advantages over other statistical tools, such as maximum likelihood estimation (MLE) and least square estimation (LSE), in estimating the parameters characterizing failure modelling. Indeed, Bayesian inference can incorporate prior beliefs and information into the analysis, which could partially overcome the lack of data. Accordingly, this paper aims to provide a closed-mathematical representation of Bayesian analysis for reliability assessment of industrial components while investigating the effect of the prior choice on future failures predictions. To this end, hierarchical Bayesian modelling (HBM) was tested on three samples with distinct sizes, while five different prior distributions were considered. Moreover, a beta-binomial distribution was adopted to represent the failure behavior of the considered device. The results show that choosing strong informative priors leads to distinct predictions, even if a larger sample size is considered. The outcome of this research could help maintenance engineers and asset managers in integrating their prior beliefs into the reliability estimation process.
Koshu GRoup Activity, Active Play and Exercise (GRAPE) Study: A Cluster Randomised Controlled Trial Protocol of a School-Based Intervention among Japanese Children
Authors: Yamakita Mitsuya , Ando Daisuke , Sugita Hayato , Akiyama Yuka , Sato Miri , Yokomichi Hiroshi , Yamaguchi Kaori , Yamagata Zentaro
Published: March 2021

School-based programmes need to be effective, easy for all, easy to perform within a short duration, and inexpensive. However, no studies have reported whether voluntarily and very short-time active play programmes contribute to improved health outcomes. This study aims to describe the GRoup activity, Active Play and Exercise (GRAPE) cluster randomised controlled trial that examined whether active play interventions of very short durations contribute to increasing physical activity (PA) and bone mass among school-aged children. The trial was conducted in 2018 from January to June, and the activity comprised ≥2 children jumping together for approximately 10 s per session, at least five times a day (approximately 1 min/day). School clusters, pair-matched as per school size (total number of children) and region, were randomly allocated to either intervention or wait-list control groups. The primary outcomes comprised objectively measured changes in PA levels (moderate-to-vigorous PA) evaluated using wrist-worn activity trackers from baseline to the one-year follow-up (six-month post-intervention follow-up) and changes in bone mass evaluated using calcaneus quantitative ultrasound parameters. This study could describe the problems and challenges in school-based PA intervention studies and present findings that could make a potentially important contribution to health education and PA promotion.
User Involvement in the Handover between Mental Health Hospitals and Community Mental Health: A Critical Discourse Analysis
Authors: Jørgensen Kim , Rasmussen Tonie , Hansen Morten , Andreasson Kate , Karlsson Bengt
Published: March 2021

Introduction: This study aimed to explore how healthcare professionals and users could perceive user involvement in the handover between mental health hospitals and community mental healthcare, drawing on the discourse analysis framework from Fairclough. Methods: A qualitative research design with purposive sampling was adopted. Five audio-recorded focus group interviews with nurses, users and other health professionals were explored using Fairclough’s discourse analysis framework. Ethical approval: The study was designed following the ethical principles of the Helsinki Declaration and Danish Law. Each study participant in the two intersectoral sectors gave their informed consent after verbal and written information was provided. Results: This study has shown how users can be subject to paternalistic control despite the official aims that user involvement should be an integral part of the care and treatment offered. As evidenced in discussions by both health professionals and the users themselves, the users were involved in plans with the handover on conditions determined by the health professionals who were predominantly focused on treating diseases and enabling the users to live a life independent of professional help. Conclusions: Our results can contribute to dealing with the challenges of incorporating user involvement as an ideology in the handover between mental health hospitals and community mental health. There is a need to start forming a common language across sectors and, jointly, for professionals and users to draw up plans for intersectoral care.
Suicidal Ideation of Men with Alcohol Use Disorder in South Korea: A Structural Equation Modeling Analysis
Authors: Hong Hyon Joo , Shin Sung Hee
Published: March 2021

South Korea’s suicide rate has been ranked second among OECD countries, and the rate of suicidal ideation is the highest among men with alcohol use disorder. To test a hypothetical model of men with alcohol use disorder based on O’Connor’s integrated motivational-volitional model, a study was conducted at a psychiatric outpatient clinic, a community addiction management center, and an Alcoholics Anonymous meeting in South Korea, comprising 203 men with alcohol use disorder. Data were collected using the Scale for Suicide Ideation, Barratt Impulsiveness Scale-11, Childhood Trauma Questionnaire-Short Form, Survey of Recent Life Experiences-Short Form, Defeat Scale and Entrapment Scale. The final model was a good fit to the data (χ2/df = 1.51, comparative fit index = 0.97, normed fit index = 0.92, incremental fit index = 0.97, Tucker–Lewis index = 0.96, and root mean square error of approximation = 0.05). The structural model explained 34.0% of the variance in suicidal ideation; and it validated that impulsivity, stress, defeat, and entrapment were the key factors affecting suicidal ideation. To prevent suicide among men with alcohol use disorder, it is necessary to develop a suicide prevention program that includes men’s feelings of defeat and entrapment.
Burnout Determinants among Nurses Working in Palliative Care during the Coronavirus Disease 2019 Pandemic
Authors: Gonçalves José Vítor , Castro Luísa , Rêgo Guilhermina , Nunes Rui
Published: March 2021

Nurses working in palliative care are at risk of burnout. The Copenhagen Burnout Inventory was used to determine burnout levels of nurses working in the Portuguese national network of palliative care. We evaluated the contribution of personal, work, and COVID-19 variables in three burnout subclasses: personal, work, and patient-related. A cross-sectional, exploratory, and quantitative design was employed and participants were sampled using convenience and snowball technique. An online survey was conducted and 153 nurses participated in our study. Socio-demographic characterization was conducted, levels of burnout and determinants were explored through multiple linear regression models for its three dimensions. High levels of personal, working, and patient burnout were present in 71 (46%), 68 (44%), and 33 nurses (22%), respectively. Most of them agreed that COVID-19 had an impact on their activities. Significant personal and work related burnout factors found were specialization in palliative care, self-perceived health status, unit type, weekly hours of work, and allocation to COVID-19 units. Gender was found to be a significant factor in patient-related burnout. There is a high level of burnout among nurses working in the Portuguese national network of palliative care. Measures for identification and mitigation of burnout are necessary to protect health care professionals.
Inactivation of Indigenous Microorganisms and Salmonella in Korean Rice Cakes by In-Package Cold Plasma Treatment
Authors: Kang Joo Hyun , Bai Jaewoo , Min Sea C.
Published: March 2021

The antimicrobial effects of in-package cold plasma (CP) treatment on Korean rice cakes (KRC) were evaluated. The CP treatment (25 kV) inactivated indigenous mesophilic aerobic bacteria by 0.8–1.0 log CFU/g, irrespective of the position of KRC in the package. The addition of a shaking step during CP treatment increased the reduction in microbes by ~1 log CFU/g. The microbial inactivation efficiency increased significantly when the treatment time increased from 1 to 3 min. Microbial inactivation activity was highest for packages containing eight rice cakes. The optimized CP treatment achieved a 2.0 ± 0.1 log CFU/g reduction in indigenous bacteria. In addition, the optimum CP treatment inactivated indigenous yeast and molds and Salmonella in KRC by 1.7 ± 0.1 log CFU/g and 3.9 ± 0.3 log CFU/g, respectively. No significant changes in color and firmness were observed, and the surface temperature of KRC did not exceed 22 °C after CP treatment. Moreover, CP treatment damaged the cellular membrane of Salmonella, mainly by inducing lipid peroxidation. This study demonstrates the potential use of in-package CP treatment for the non-thermal microbial inactivation of KRC.
Linking Health Literacy to Self-Care in Hypertensive Patients with Physical Disabilities: A Path Analysis Using a Multi-Mediation Model
Authors: Nam Hye Jin , Yoon Ju Young
Published: March 2021

Hypertension has been identified as the most prevalent chronic disease, accounting for the majority of premature deaths in people with physical disability in South Korea. Self-care is vital in controlling high blood pressure. Health literacy has been implicated in self-care behaviors; however, the mechanisms behind this relationship remain unclear. Therefore, the present study aimed to test a hypothetical path model estimating the association between health literacy and hypertension self-care behaviors and to verify the mediating effects of access to healthcare, provider–patient interactions, hypertension knowledge, and hypertension control self-efficacy in hypertensive people with physical disability. In total, 211 hypertensive adults with physical disability completed an online survey. A path analysis using a multi-mediation model was performed using AMOS 17.0 (IBM SPSS Inc., Chicago, IL, USA), and indirect effects were estimated using phantom variables. As a result, the model fit indices were deemed excellent. Significant indirect pathways were determined from health literacy to hypertension self-care behavior via provider–patient interactions, knowledge, and self-efficacy, although no direct association was found between health literacy and self-care behaviors. The study findings supported the importance of provider–patient interactions, knowledge, and self-efficacy, which play a role in linking health literacy and self-care behavior in hypertensive patients with physical disability.
Comparison of a Barcode-Based Smartphone Application to a Questionnaire to Assess the Use of Cleaning Products at Home and Their Association with Asthma Symptoms
Authors: Lemire Pierre , Temam Sofia , Lyon-Caen Sarah , Quinot Catherine , Sévin Etienne , Remacle Sophie , Supernant Karine , Slama Rémy , Dumas Orianne , Siroux Valérie , Le Moual Nicole ,   the SEPAGES Study Group
Published: March 2021

Household disinfectant and cleaning products (HDCPs) assessment is challenging in epidemiological research. We hypothesized that a newly-developed smartphone application was more objective than questionnaires in assessing HDCPs. Therefore, we aimed to compare both methods, in terms of exposure assessments and respiratory health effects estimates. The women of the SEPAGES birth cohort completed repeated validated questionnaires on HDCPs and respiratory health and used an application to report HDCPs and scan products barcodes, subsequently linked with an ingredients database. Agreements between the two methods were assessed by Kappa coefficients. Logistic regression models estimated associations of HDCP with asthma symptom score. The 101 participants (18 with asthma symptom score ≥1) scanned 617 different products (580 with available ingredients list). Slight to fair agreements for sprays, bleach and scented HDCP were observed (Kappa: 0.35, 0.25, 0.11, respectively). Strength of the associations between HDCP and asthma symptom score varied between both methods but all odds ratios (OR) were greater than one. The number of scanned products used weekly was significantly associated with the asthma symptom score (adjusted-OR [CI 95%]: 1.15 [1.00–1.32]). This study shows the importance of using novel tools in epidemiological research to objectively assess HDCP and therefore reduce exposure measurement errors.
Religious Affiliation in Relation to Positive Mental Health and Mental Disorders in a Multi-Ethnic Asian Population
Authors: Vaingankar Janhavi Ajit , Choudhary Niyanta , Chong Siow Ann , Kumar Fiona Devi Siva , Abdin Edimansyah , Shafie Saleha , Chua Boon Yiang , van Dam Rob M. , Subramaniam Mythily
Published: March 2021

Background: This study investigated association of religious affiliation with positive mental health (PMH) and mental disorders. Methods: A cross-sectional survey of 2270 adults was conducted in Singapore. Participants reported their religious affiliation to Buddhism, Christianity, Hinduism, Islam, Sikhism, Taoism, or other religions. A PMH instrument measured total PMH and six subcomponents: general coping (GC), emotional support (ES), spirituality (S), interpersonal skills (IS), personal growth and autonomy (PGA), and global affect (GA). Lifetime history of mental disorders was assessed with the Composite International Diagnostic Interview. Results: Total PMH (mean ± SD) was 4.56 ± 0.66 for participants with any religion versus 4.12 ± 0.63 (p = 0.002) in those without any religion. After adjustment for all potential confounders, the mean difference in total PMH between these groups was 0.348 (95% CI: 0.248–0.448). Having any religion was significantly associated with higher scores for S, GC, ES, IS, but not with PGA, GA or mental disorders. Compared with individuals without any religion, total PMH and S levels were significantly higher across all religions. Additionally, Christianity was significantly associated with higher ES, Taoism with higher GC, Buddhism and Islam with higher GC, ES and IS, Hinduism with higher IS and Sikhism with higher ES and IS. Conclusion: Our results indicate that religious affiliation is significantly associated with higher PMH, but not with mental disorders in an Asian community setting. In addition, different religions showed unique patterns of association with PMH subcomponents.
Comparing Methods to Impute Missing Daily Ground-Level PM10 Concentrations between 2010–2017 in South Africa
Authors: Arowosegbe Oluwaseyi Olalekan , Röösli Martin , Künzli Nino , Saucy Apolline , Adebayo-Ojo Temitope Christina , Jeebhay Mohamed F. , Dalvie Mohammed Aqiel , de Hoogh Kees
Published: March 2021

Good quality and completeness of ambient air quality monitoring data is central in supporting actions towards mitigating the impact of ambient air pollution. In South Africa, however, availability of continuous ground-level air pollution monitoring data is scarce and incomplete. To address this issue, we developed and compared different modeling approaches to impute missing daily average particulate matter (PM10) data between 2010 and 2017 using spatiotemporal predictor variables. The random forest (RF) machine learning method was used to explore the relationship between average daily PM10 concentrations and spatiotemporal predictors like meteorological, land use and source-related variables. National (8 models), provincial (32) and site-specific (44) RF models were developed to impute missing daily PM10 data. The annual national, provincial and site-specific RF cross-validation (CV) models explained on average 78%, 70% and 55% of ground-level PM10 concentrations, respectively. The spatial components of the national and provincial CV RF models explained on average 22% and 48%, while the temporal components of the national, provincial and site-specific CV RF models explained on average 78%, 68% and 57% of ground-level PM10 concentrations, respectively. This study demonstrates a feasible approach based on RF to impute missing measurement data in areas where data collection is sparse and incomplete.
Educational and Employment Outcomes among Young Australians with a History of Depressive Symptoms: A Prospective Cohort Study
Authors: Witt Katrina , Milner Allison , Evans-Whipp Tracy , Toumbourou John W. , Patton George , LaMontagne Anthony D.
Published: March 2021

The aim of this study was to investigate whether depressive symptoms reported during adolescence are associated with subsequent educational and employment outcomes, including whether experiences of depressive symptoms in adolescence are associated with higher exposures to adverse psychosocial job stressors among those who were employed in emerging adulthood. We used data from the Victorian arm of the International Youth Development Study (IYDS). Multiple logistic regression analyses were used to model the association of depressive symptoms reported in 2002 (wave one) and/or 2003 (wave two) and self-reported completion of compulsory secondary schooling, employment status, and exposure to a number of psychosocial job stressors roughly a decade later (i.e., at wave three in 2014). In fully adjusted models, reporting high depressive symptoms at waves one or two (odds ratio (OR) 0.71, 95% confidence interval (CI) 0.55 to 0.92), as well as at both waves (OR 0.55, 95% CI 0.41 to 0.75) were associated with a reduced likelihood of completing secondary schooling by wave three. High depressive symptoms reported at multiple waves were also associated with a reduced likelihood of employment (OR 0.49, 95% CI 0.36 to 0.66). Amongst those employed at wave three (n = 2091; 72.5%), adolescent depressive symptoms were associated only with workplace incivility. Psychosocial job stressor exposures should be considered in the design and selection of jobs for young workers with a history of depressive symptoms in order to increase employment participation and sustainability for young people experiencing symptoms of depression.