bluuebunny/crossref_metadata_2025 huggingface dataset:
ПЕПТИДНЫЙ ОБОГАЩЕННЫЙ МОДУЛЬ ФУНКЦИОНАЛЬНОЙ НАПРАВЛЕННОСТИ ДЛЯ ПРОФИЛАКТИКИ ОЖИРЕНИЯ И ГИПЕРЛИПИДЕМИИ
Authors: Табакаев  Антон Вадимович Табакаев  Антон Вадимович , Табакаева Оксана Вацлавовна
Published: April 2024

В настоящей работе приведены результаты исследований получения пептидного модуля функциональной направленности, обогащенного микроэлементом цинком и таурином для профилактики гиперлипидемии и ожирения. Пептидный модуль получали путем биотехнологической модификации мягких тканей двустворчатого моллюска Дальневосточного региона Anadara broughtonii с использованием ферментного препарата - протеаза щелочная протозим В, условия процесса -  рН 7,0-7,2, температуре 50 0С, продолжительность 24 ч. Обогащение цинком проводили реакцией комплексообразования путем внесения в пептидный модуль 20%-ного водного раствора ZnCl2 в соотношении по массе 6,25 × азот в жидкой фракции : хлорид цинка = 10:1. Условия процесса: температура 20-25°С, продолжительность 60 мин, рН 7,0-7,1. Содержание высокомолекулярной фракции (массой более 160 кДа) было низким и составляло не более 1,2%. Максимально представленными фракциями являются низкомолекулярные фракции с массами 6,5-12,5 кДа, 12,5-18 кДа и 1,4-6,5 кДа. Низкомолекулярные фракции массой не более 24 кДа максимально определены в  пептидном модуле мантии – 89,3%. Полученные пептидные модули имели достаточно  высокое содержание таурина - 28,48-30,15% от суммы аминокислот. Максимально из незаменимых аминокислот представлены  лейцин, лизин, валин, изолейцин, условно-незаменимая аминокислота аргинин. Максимальное связывание микроэлемента цинка как в пептидном модуле мускула, так и мантии, происходит во фракциях с молекулярными массами 12,5-18 кДа и 6,5-12,5 кДа. Суммарно 81,1% (мускул) и 83,7% (мантия) цинка связано в низкомолекулярных фракциях массами от 24 до менее 1,4 кДа. Минимальная массовая доля цинка определена в высокомолекулярных фракциях массами более 160кДа и 67-160 кДа – суммарно 4,2% (мантия) и 4,5% мускул. Использование в пищевых системах полученных пептидных модулей, обогащенных цинком и таурином, будет оказывать влияние на метаболический синдром, в том числе и на профилактику гиперлипидемии и ожирения.
МЯСНАЯ СНЕКОВАЯ ПРОДУКЦИЯ С ДОБАВЛЕНИЕМ ЯГОДНОГО ПОРОШКА ИЗ ВЫЖИМОК RÚBUS SAXÁTILIS L.
Authors: Рыгалова Е.А. , Шароглазова Л.П. , Величко Н.А. , Смольникова Я.В.
Published: April 2024

Независимый портал «Мясной Эксперт», отражающий перспективы направлений производства мясных продуктов, опубликовал результаты изучения глобального рынка, проведенные чикагским исследовательским институтом, которые показали, что продажи и потребление разных видов снековых продуктов и закусок растут, так как потребителям интересен такой вид продукции [1‒5, 20‒27]. В связи с этим производство снековых продуктов питания (в том числе и обогащенных функциональными ингредиентами) становится одним из самых актуальных и перспективных направлений в пищевой промышленности. Статья содержит результаты исследования по созданию новой рецептуры мясных снеков, обогащенных ягодным порошком из выжимок костяники каменистой (Rúbussaxátilis L.) и оценке соответствия разработанного продукта требованиям качества и безопасности. Органолептическая оценка опытных образцов показала, что разработанные мясные изделия удовлетворяют нормативной документации снеков (ГОСТ 34159-2017 [8]), полученные образцы изделия имели приятный пряный аромат, чистый, свойственный сыровяленым изделиям вкус с ягодным послевкусием, красивый красный цвет. Наилучшим по органолептической оценке был образец мясных снеков (реструктурированных чипсов) с добавлением порошка из ягодных выжимок костяники каменистой (Rúbussaxátilis L.) в количестве 0,75 % от массы мясного сырья. Результаты физико-химических показателей наилучшего по выбору экспертов в органолептическом исследовании образца мясных снеков в дозировке 0,75 % от массы мясного сырья (массовые показатели жира 19,40 %; поваренной соли 1,98 %; нитрита натрия 0,0026 %; белка 20,90 %) и показатели безопасности (микробиологические показатели, содержание токсичных элементов, пестицидов, нитрозаминов, антибиотиков, радионуклидов) соответствуют ГОСТ 34159-2017, ТР ТС 034/2013, ТР ТС 021/2011 и СанПиН 2.3.2.1078-2001 [6–9].
ЧИСЛЕННОЕ МОДЕЛИРОВАНИЕ УЛАВЛИВАНИЯ МЕЛКОДИСПЕРСНЫХ ЧАСТИЦ КАТАЛИЗАТОРА СЕПАРАЦИОННЫМ УСТРОЙСТВОМ С ДУГООБРАЗНЫМИ ЭЛЕМЕНТАМИ
Authors: Салахова Эльмира Ильгизяровна , Зинуров Вадим Эдуардович , Абдуллина  Азалия Айратовна Абдуллина  Азалия Айратовна , Дмитриева Оксана Сергеевна , Мадышев  Ильнур Наилович Мадышев  Ильнур Наилович , Титенков Вячеслав Владимирович
Published: April 2024

Механическое разрушение частиц катализатора в псевдоожиженном слое значительно сокращает срок их службы и увеличивает эксплуатационные расходы. Процессы дробления и истирания частиц катализатора зависят от множества факторов и приводят к образованию мелкодисперсной пыли, которая будет вынесена из реактора газовым потоком. Главной проблемой на производстве является недостаточно высокая степень очистки выбросов дымовых газов от катализаторной пыли с помощью циклонов. В работе авторским коллективом предложена конструкция сепарационного устройства с дугообразными элементами и решеткой, состоящих из множества пластин. Представлена трехмерная модель устройства. Описан механизм улавливания мелкодисперсных частиц в нем. Отмечено конструктивное расположение дугообразных элементов в рядах друг относительно друга. Исследование улавливания твердых частиц пыли сепарационным устройством с дугообразными элементами проводились численным путем в программном комплексе Ansys Fluent. В ходе исследований было изучено влияние расходных характеристик потока газа, размер частиц пыли, толщина дугообразных элементов на эффективность работы устройства. Получено, что при меньших толщинах дугообразных элементов (2-3 мм) достигается наибольшая эффективность сепарационного устройства, т.к. волнообразная структура потока близка к идеальной. Наиболее оптимальной скоростью газопылевого потока на входе в сепарационное устройство является 0,5-1 м/с. Эффективность аппарата в среднем составляет 86,5 %. Обработку опытных данных произвели в критериях подобия, построив зависимость Eu = f(Re). Установлено, что во время абразивного истирания частиц в качестве аппарата улавливания можно использовать сепарационное устройство с дугообразными элементами, высокая эффективность при низком перепаде давления достигается за счет создания упорядоченной волнообразной структуры газопылевого потока, на основе которой возникают центробежные силы высоких значений при относительно низких скоростях газа на входе в устройство.
АНТИФРИКЦИОННЫЕ ЭПОКСИДНЫЕ МАТЕРИАЛЫ, НАПОЛНЕННЫЕ СИЛИКАТАМИ НА ОСНОВЕ ИСКОПАЕМОГО, РАСТИТЕЛЬНОГО И ТЕХНОГЕННОГО СЫРЬЯ
Authors: Готлиб Елена Михайловна , Ямалеева Екатерина Сергеевна , Валеева  Алина Равилевна Валеева  Алина Равилевна , Твердов  Илья Дмитриевич Твердов  Илья Дмитриевич , Поволоцкий Александр Давидович
Published: April 2024

В статье рассматривается применение силикатов кальция и магния в качестве наполнителей эпоксидных материалов. Исследуются наполнители, которые получены на основе природного, растительного и техногенного сырья, то есть на базе природных минералов, золы рисовой шелухи и отходов черной металлургии. Эти наполнители повышают твердость на 14 %, износостойкость эпоксидных композиций на 37 %, прочность при изгибе до 55% и адгезию к стали до 75%, при этом снижая коэффициент статического трения на 67 %. В работе также рассматривается зависимость физико-механических свойств эпоксидных материалов от концентрации в них наполнителя. Экспериментально доказано, что оптимальным является соотношение компонентов 5-15 мас. ч. наполнителя на 100 мас.ч эпоксидной смолы. Диопсид содержащий наполнитель техногенного происхождения обеспечивает значительно большее снижение коэффициента статического трения материалов, то есть их лучшие трибологические характеристики, как по сравнению с применением Миволл 10-97, так и синтетического волластонита на основе золы рисовой шелухи. Полученные результаты свидетельствуют о том, что, характер модифицирующего действия силикатных наполнителей практически не зависит от их состава, который влияет только на величину конкретных эксплуатационных показателей.
ИЗМЕНЕНИЕ ОБЪЁМА ЗАКРИСТАЛЛИЗОВАННОЙ ВОДЫ КАК РЕЗУЛЬТАТ ВОЗДЕЙСТВИЯ ЭЛЕКТРОМАГНИТНОГО ПОЛЯ. ВЛИЯНИЕ ПРЕДЫСТОРИИ ВОДЫ
Authors: Шипунов Борис Павлович , Терентьева  Юлия Владимировна Терентьева  Юлия Владимировна
Published: April 2024

Аннотация. Изучен процесс кристаллизации воды подвергшейся влиянию высокочастотным электромагнитным полем частотой 30-200 МГц. В качестве объекта воздействия была выбрана талая вода, полученная расплавлением льда, в качестве предмета отклика – размер ледяного керна при кристаллизации воды. Дополнительным фактором было использовано время выдержки воды после полевого воздействия, которое варьировалось от 0 до 21 суток. Проведено сопоставление эффективности полевого воздействия с ранее полученными результатами, где в качестве объекта воздействия использовалась дистиллированная вода. Сопоставление результатов выявило существенное отличие в восприятии высокочастотного поля водой различного происхождения. Максимальное совпадение зависимостей наблюдается для частот 200 и 60 МГц. Набольшее расхождение – для всех остальных частот 30, 90, 110, 140 и 170 МГц. для частоты 170 МГц наблюдается существенная дифференциация изменений размеров керна: для малых времён существенны изменения для дистиллированной воды, для максимальных – для талой. Примерно такая же зависимость наблюдается и в случае частоты 90 МГц. Тогда как для частоты 140 МГц наблюдаются слабые изменения при малых временах выдержки после полевого воздействия, и очень существенные при максимально исследованном времени – 21 сутки. Для частоты 110 МГц талая вода проявила очень слабый отклик на полевое воздействие, по сравнению с дистиллированной. Столь существенная дифференциация результатов полевого воздействия для талой воды и дистиллата, по-видимому, является следствием сложной внутренней организации как дистиллированной, так и талой воды. Предложено объяснение наблюдаемым зависимостям, которое базируется на современном представлении о полиморфном представлении о структурной организации воды и специфическом восприятии каждой структурной организации полевого воздействия.
Application of Trichoderma micromycetes and trichoderma-based consortia in agrobiotechnology (review)
Authors:   Vyatka State Agrotechnological University, Domracheva L. I. ,   Institute of Biology of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, Starikov P. A. ,   Vyatka State Agrotechnological University, Kovina A. L. ,   Vyatka State Agrotechnological University, Ashikhmina T. Ya. ,   Institute of Biology of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences,   Vyatka State University
Published: April 2024

The review presents the results of studies on the role of Trichoderma spp. micromycetes in soil microbiomes, on the emerging syntrophic relationships that promote the co-prosperity of various microbial trichoderma consortia. Physiological and biochemical characteristics of Trichoderma is the basis for the creation of biological products with multifunctional action, in particular, for use in agriculture as a biocontrol agent, a growth stimulator of higher plants, and a bioremediator of contaminated soils. Of particular interest are studies devoted to the creation of associations of Trichoderma with nitrogen-fixing bacteria, since in the future it is precisely such biological products that have the greatest potential both in protecting plants from infections and in increasing soil fertility. Analysis of literary data shows that Trichoderma spp. is one of the most promising agrobiotechnology objects. Their unique properties applied in agriculture are due to their metabolism characteristics, the specificity of the secreted secondary metabolites, as well as the ability to symbiotic and antagonistic relationships with other organisms, both microbes and higher plants. Trichoderma was originally used as a phytopathogen antagonist in the development of biological products due to the release of various antibiotics. In addition to antibiosis, the protective properties of Trichoderma towards higher plants are manifested in the ability to mycoparasitize phytopathogens through chemotrophic and chitinase activity. An inventory of Trichoderma exometabolites shows that a significant portion of its produced compounds positively affect higher plants, including growth-stimulating and immunomodulatory effect, the ability to destroy mycotoxins, and to activate water exchange and photosynthesis processes. The combined use of Trichoderma with free-living and symbiotic nitrogen fixers is of particular interest in recent years. Research on the use of such consortia has shown the prospects for application not only in equatorial and subequatorial latitudes but also in the temperate climatic zone.
Comprehensive assessment of the ecological state of the transboundary Narva River
Authors:   St. Petersburg Federal Research Center of the Russian Academy of Sciences, Kuznetsova T. V. , Manvelova A. B. ,   St. Petersburg Federal Research Center of the Russian Academy of Sciences, Polyak Y. M. ,   St. Petersburg Federal Research Center of the Russian Academy of Sciences
Published: April 2024

A comprehensive study of the ecological state on the transboundary Narva River (Russia –Estonia border) downstream of Ivangorod, Kingisepp District, Leningrad Region, was carried out. It included the determination of chemical indicators of pollution of the natural river water, with an emphasis on some heavy metals content in water, sediments and soft tissues of local filter-feeding mollusks; the latter were used as bioindicators of river pollution in this location. Zn was determined in maximum concentrations in bottom sediments, then Cu, to a lesser extent Pb, Cd and Ni. The coefficient of metal bioconcentration calculated in soft tissues of mollusks showed maximum for Zn and Cu, to a lesser extent for Pb, Cd and minimum for Ni. However, such values have no negative effect on local biota as shown by physiological testing of bivalves from study site. The functional assessment of bivalves by non-invasive cardiac rhythm recording made it possible to characterize their functional status and adaptive capabilities as good. The relative abundance of hydrocarbon-oxidizing bacteria in the digestive tract of mollusks from the Narva River has been determined as an indicator of environmental pollution by oil products. It was noted that the number of hydrocarbon-oxidizing bacteria does not exceed the values characteristic of the reference waters of the Eastern Gulf of Finland. Based on the totality of the studies, it was concluded that the river waters in the studied location can be characterized as slightly polluted and its ecological status as of a good quality.
Primary pedogenesis on different texture substrates in post-technogenic ecosystems of the taiga zone
Authors:   Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, Likhanova I. A. , Kuznetsova E. G. ,   Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, Kholopov Yu. V. ,   Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, Deneva S. V. ,   Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, Lapteva E. M. ,   Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences
Published: April 2024

The paper focuses on the primary soil formation under automorphic conditions in the middle taiga sub-zone of the European North-East of Russia (Komi Republic) on the post-technogenic territories (quarries for the extraction of minerals (construction sand)) with different soil materials (ancient alluvial sands; fluvioglacial sands and sandy loams, moraine loams). In the quarries, the processes of soil formation and vegetation cover development are interdependent and are affected by the properties of soil-forming rocks. Along with the improvement of soil properties (from sandy loam to loam), the biometric parameters of pine stands increase; in the ground cover, dominating lichens are replaced by mosses, and then by grasses. The biogenic accumulation rates of organic matter increase along with the transition of soil material to fine-textured. In automorphic conditions, the accumulation rate of Corg. in soil of sandy quarry under sparse young lichen pine forest reaches 0.1, in sandy loam under young forb-moss pine forest – 0.3, in loam under young grass-forb pine forest – 0.6 t/ha/year. Already in the first succession decades, every study soil demonstrates weakly expressed processes of eluviation and illuviation (the beginning of podzolization). These processes are evidenced by morphological signs (the appearance of bleached quartz grains and whitish patches under organic horizon and in its lower part), redistribution of silicon, iron, and aluminum compounds, as well as of silty particles proportion.
Obtaining and application iodinated bactericide for water disinfection in local treatment systems
Authors:   Yuri Gagarin State Technical University of Saratov, Vedeneeva N. V. , Tikhomirova E. I. ,   Yuri Gagarin State Technical University of Saratov, Koshelev A. V. ,   Federal State Unitary Enterprise “State Research Institute of Organic Chemistry and Technology” (FGUP “GosNIIOKhT”), Golovkov V. F. ,   Federal State Unitary Enterprise “State Research Institute of Organic Chemistry and Technology” (FGUP “GosNIIOKhT”)
Published: April 2024

The paper presents the results of studies on obtaining a bactericide based on iodized anion exchange resin АВ-17-8. The obtained compound bactericidal efficiency was assessed on Escherichia сoli culture suspensions at 103–109 CFU/mL. All experiments gave positive results and demonstrated the possibility of their use for natural water treatment in local water treatment systems. The obtained bactericidal filter can be used for quantitative determination of bacteriological contamination of the studied waters. Water samples contaminated with E. coli at 500, 1000, 5000 and 10000 CFU/mL were prepared to quantify the bactericidal activity of the iodine-containing compound obtained on an anion-exchange resin. Then samples were sequentially passed through a 100 cm3 bactericidal filter. By the amount of iodine released, the degree of microbial contamination can be determined. There were no microbial cells in the filtrate at zero concentrations of released iodine in the solution. The degree of microbiological contamination of water Q was 10,000 CFU/mL at 0.00391 g/L of iodine. A linear dependence between bactericidal activity and iodine release from the anion-exchange resin was established. This allows us to assume that the positive iodine radical is released “on a signal” – at the appearance of living microorganisms carrying excessive electrostatic charge. The released by the bactericide positive iodine radical (I*+) interacts only with the electrostatic charge of microorganisms, and not with the functional groups of their shells. The found quantitative dependence makes it possible to determine microbiological contamination based on the iodine concentration in the treated solution. Based on the test results, a flowchart of the technological process of surface water treatment was proposed. The presence of a bactericidal filter allows the use of a reverse osmosis filter, sensitive to biological water contaminants, as part of the installation.
Simvastatin’s Mitochondrial Defenses against Angiotensin II-Induced Heart Failure
Authors:   Apollo College of Pharmacy, Anjora, Durg (C.G), India, Sonwani Hari Prasad
Published: April 2024

Background and Aims: Heart failure is one cardiovascular condition that might progress due to mitochondrial dysfunction. In chronic heart failure, 3hydroxy-3-methylglutaryl CoA reductase inhibitors (statins), which prevent the production of ROS, have cardioprotective benefits. However, it is still unknown how statins can protect the mitochondria in heart failure Experimental Strategy: Angiotensin II (1.5 mg/kg/day) or co-administered simvastatin (oral, 10 mg/kg/day) were given to rats for 14 days, after which the treatment was withdrawn. Wheat germ agglutinin staining and echocardiography were used to analyze the structure and function of the heart. Transmission electron microscopy was used to analyze the shape of the mitochondria as well as the numbers of lipid droplets, lysosomes, autophagosomes, and mitophagosomes. After stimulating human cardiomyocytes, flow cytometry was used to assess changes in intracellular ROS and mitochondrial membrane potential (m). and, respectively, JC1 staining. By using immunohistochemistry and western blotting, apoptotic proteins that are associated to autophagy, mitophagy, and mitochondrial regulation were identified. Key outcomes Simvastatin mitigated the disruption of m and dramatically decreased ROS generation. Simvastatin stimulated autophagy and mitophagy, caused lipid droplets to accumulate, and provided energy for maintaining mitochondrial function and impeded apoptosis that was mediated by mitochondria. According to these results, simvastatin-mediated mitochondrial protection prevents heart failure by modifying antioxidant status and enhancing energy sources for autophagy and mitophagy, which prevent mitochondrial damage and cardiomyocyte apoptosis. Final Thoughts and Implications Mitochondria are crucial in controlling the course of heart failure. Simvastatin reduced angiotensin II-induced heart failure through mitochondrial preservation and may offer a new treatment for heart failure prevention.
A Radiological Review of the Varied Duodenal Lesions with Histopathological Correlation
Authors:   Centre of Excellence in Radiology and Imaging Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, R Ramachandran , J Dhamodaran ,   Centre of Excellence in Radiology and Imaging Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, P Paneerselvam ,   Centre of Excellence in Radiology and Imaging Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, S Balasubramanian ,   Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, R Rangasami ,   Centre of Excellence in Radiology and Imaging Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, India
Published: April 2024

Majority of the duodenal lesions have received little attention in imaging literature in comparison with jejunum and ileum as most of them are primarily investigated with conventional endoscopy. Cross sectional imaging techniques–Multi Detector Computed Tomography (MDCT) and Magnetic Resonance Imaging (MRI) have dramatic improvement in diagnostic capabilities as they can analyse the wall of the duodenum, intraluminal content, submucosal extent of the disease, and infiltration into the surrounding viscera. Few of the duodenal lesions have overlapping imaging characteristics and it is crucial to correlate these conditions with histopathological analysis for definitive diagnosis. The main aim of this imaging review is to elucidate the diverse spectrum of duodenal lesions with emphasis on CT and MRI imaging features.
Update on Treatment of Covid-19 in Children
Authors:   Department of Pediatrics, Military Hospital, Sudan, Mohammed Taghreed Abdeen
Published: April 2024

Since its emergence in December 2019 in Wuhan, China, more than three years, and a half has passed, yet the world is still grappling with the far-reaching impacts of the COVID-19 pandemic. Many countries endured a devastating blow during the second wave of COVID-19, witnessing a significant rise in severe cases among children and instances of multisystem inflammatory syndrome in children, surpassing the numbers seen during the initial wave of the pandemic [1]. While numerous countries have successfully developed effective COVID-19 vaccines for adults, options for pediatric populations have only recently emerged. The Drugs Controller General of India (DCGI) granted emergency approval for the use of COVISHIELD and COVAXIN in pediatric patients aged 12 years and older [2]. However, despite considerable research efforts, a definitive cure or treatment for COVID-19 remains elusive. Several drugs, including remdesivir, casirivimab/imdesivimab, ivermectin, baricitinib, and tofacitinib, have garnered significant attention, but none can be hailed as a panacea [3].
Synthesis of N-beta-brominated alkenyl isothiocyanates via dehydrogenation of alkyl isothiocyanates
Authors: Maeda Bumpei , Akiyoshi Ryohei , Tanaka Daisuke , Sato Kohei , Murakami Kei
Published: April 2024

This study presents a new dehydrogenative synthesis of alkenyl isothiocyanates, providing compounds with bromo and isothiocyanate groups. These reactive functionalities offer versatility for further transformations. Application in an amine sensor utilizing a coumarin-attached product demonstrates practical utility. This streamlined approach facilitates access to alkenyl isothiocyanates, valuable tools for biological studies.
An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization
Authors: Rial-Rodríguez Eduardo , Williams Jason D. , Cantillo David , Fuchß Thomas , Sommer Alena , Eggenweiler Hans-Michael , Kappe C. Oliver , Laudadio Gabriele
Published: April 2024

Automated batch and flow reactors are well-established for high throughput experimentation in both thermal chemistry and photochemistry. However, the development of automated electrochemical platforms is hindered by cell miniaturization challenges in batch and difficulties in designing effective single-pass flow systems. In order to address these issues, we have designed and implemented a new, slug-based automated electrochemical flow platform. This platform was successfully demonstrated for electrochemical C-N cross-couplings of E3 ligase binders with diverse amines (44 examples), which were subsequently transferred to a continuous-flow mode for confirmation and isolation. To further validate the versatility of the platform, Design of Experiments (DoE) optimization was performed for an unsuccessful library target. This optimization process, fully automated by the platform, resulted in a remarkable 5-fold increase in reaction yield.
Analysis of Climate Norms in the Trans-Baikal Territory
Authors:   Institute of Natural Resources, Ecology and Cryology SB RAS, Noskova E. V. , Vakhnina I. L. ,   Institute of Natural Resources, Ecology and Cryology SB RAS
Published: April 2024

Using observational data from 27 meteorological stations of the Roshydromet network, on average for the territory of the Trans-Baikal Territory and its geoadministrative regions, the values of climatic norms for four operational periods recommended by the WMO (1961–1990, 1971–2000, 1981–2010, 1991–2020) were calculated and analyzed. , and general (1961–2020) for surface air temperature and precipitation. Updated data on climate norms and their dynamics over different time intervals are of particular importance for ensuring the economic sustainability and environmental security of the Russian Federation in the context of current climate trends. The purpose of this study was to assess the regional features of changes in climatic norms of air temperature and precipitation in the territory of the Trans-Baikal Territory. The results of the study showed that the warming observed in the Trans-Baikal Territory led to an increase in the norms, the average annual values of which with each subsequent period are 0.3–0.4 °C higher than in the previous one. On average, over the region, the largest contribution to the increase in climatic norms of average annual air temperatures for the cold season was observed in 1971–2000, for the warm season in 1981–2010. An analysis of air temperature anomalies calculated as deviations from the average value for the base period 1991–2020 shows that positive anomalies on average over the territory of the region began to be recorded only since 1990. Then the mode of precipitation here is characterized by cyclicity. An analysis of precipitation anomalies shows that, in general, their negative values correspond to the dry phases of the cycle, while positive values correspond to wet ones, although wet years are noted in arid years, and dry years in humid ones. The average difference between the sum of atmospheric precipitation of different phases is about 50 mm. The values of climatic norms correspond to their average number for the general period. Precipitation norms do not reflect the climatic situation, and in order to solve applied problems in climate-dependent industries and adopt management strategies, it is more expedient to take into account the cycle phase of the territory's humidification regime.
Quantum Geography: Problems of Typification, Classification and Zoning
Authors:   V. B. Sochava Institute of Geography SB RAS, Cherkashin A. K.
Published: April 2024

The possibility of using the mathematical apparatus of the quantum theory of computer science for modeling geographical phenomena in solving problems of typification, classification and zoning to explain the reasons for the integrity of territorial objects is discussed. The methods of trivial and principal bundles of differential geometry and functional analysis of virtual internal spaces of geosystems (geomers and geochores) are used. The advantage of the quantum description lies in the linear simplicity of equations and formulas reflecting both the typical functions of discrete quantum states of geosystems and the superposition of these states realized in the observed spatial patterns in nature and society. This approach is the result of the ascent from a simple understanding of geographical objects as systems of continuous connection of elements to the allocation of independent discrete layers of independent functioning (geomers), their polysystem equivalence in geochores and holysystem integrity in region. The integrity of objects is described by general equations that do not take into account the influence of the geographical environment, therefore they allow creating models of different geosystems in the same way. For quantitative analysis of cartographic data, methods of reliability theory are used, based on the identification of frequency distributions of geomer areas by height, calculation of reliability and safety indicators. The application of the ideas of quantum geoinformatics is demonstrated by the example of assessing the factorial influence on the habitus of landscapes based on the signs of territorial manifestation of facies of different factorial series (facies classes) of the localities of the Maly Khamar-Daban ridge and the altitude distribution of the geomes of the Transbaikalia.
Exploring the Bookkeeping Practices of Family-owned Business: A Case Study of Carriaga Traders Mart
Authors: Casas Cristine Mae , Cariaga Eunice , Adlawan Khate Marie , Batingal Ace Virgel , Sumicad Elijen
Published: April 2024

Carriaga Traders Mart (CTM), an established retail business, has transitioned from a small grocery store to a thriving enterprise, offering a diverse array of affordable products. Their sustained success is attributed to meticulous bookkeeping practices. This study explores how a family-owned business can effectively implement bookkeeping practices to address unique bookkeeping challenges, offering valuable insights from CTM's experiences that benefit entrepreneurs, investors, and policymakers. Positive Accounting Theory (PAT) underpinned this investigation, shedding light on how economic, political, market factors, and contracting considerations influence bookkeeping practices, particularly in the context of CTM. The research employed a qualitative case study approach. Through extensive interviews with key financial management personnel, it gained comprehensive insights into the company's bookkeeping and financial practices. Participants included individuals directly involved in CTM's bookkeeping and financial management, meticulously selected based on their expertise in the field. The study's findings underscored CTM's meticulous bookkeeping practices, encompassing technology-driven sales recording, rigorous expense management, and a commitment to financial transparency. The study recommends that entrepreneurs adopt advanced accounting software and technology to enhance efficiency, implement risk mitigation strategies, and prioritize cross-functional personnel training to strengthen their financial practices. For financial managers, the study suggests investing in ongoing training, diversifying financial tools and methods, and emphasizing skill development to navigate the ever-evolving business landscape effectively. In conclusion, this research contributes to the discourse on bookkeeping practices, bridging theoretical insights from PAT with practical knowledge from CTM. It underscores the importance of a versatile and adaptive approach to bookkeeping practices in real-world business settings.
Radioecological situation in certain areas of the Southern Federal District
Authors: Plahotnyаyа D. P. , Buraeva E. A. , Ratushnyj V. I.
Published: April 2024

Radioecological monitoring of natural and urban areas is intended not only to assess the consequences of the operation of nuclear fuel energy enterprises, but also to ensure radiation safety of humans and the environment. This type of research allows not only to identify areas with increased background radiation, but also to reduce social tension in the population associated with radiophobia. This paper presents the results of long-term studies of the ambient dose equivalent rate (ADR) of gamma radiation within urban and rural settlements of the Southern Federal District using the example of the Krasnodar Territory. ADR measurements were carried out at a height of 100 cm from the earth's surface using dosimeters-radiometers SRP-88n, DRBP-03 and DKS-96s with a detection unit BDKS-96s using pedestrian gamma survey methods. The study regions represent different types of landscapes: steppe plain territories, the foothills of the North Caucasus and the Black Sea coast. It is shown that the arithmetic average ADR values in urban conditions are 0.11 μSv/h, and in rural settlements – 0.14 μSv/h. Similar results may be due to differences in soil and climatic conditions in different settlements. In general, differences in gamma radiation ADR may be due to a greater extent to measurement uncertainty (standard deviation), and also, to a lesser extent, to relief features and the content of radionuclides in the soils of a given region. The radiation situation in the Krasnodar Territory at the time of the study complies with the requirements of SanPiN 2.6.1.2612-10. The gamma radiation equivalent dose rate values are within the limits of natural background fluctuations characteristic of the Russian Federation.
Study on the Accuracy of Serum Prealbumin Level in Predicting the Prognosis of Patients with Critical Respiratory Illness
Authors: Wang Xiang , Xie Zuozhou , Zhao Jinhong , Liu Yi
Published: April 2024

Objective: To analyze the accuracy of serum prealbumin levels in predicting the prognosis of patients with critical respiratory illness. Methods: Fifty patients with critical respiratory illness admitted to our hospital from October 2022 to September 2023 were selected and divided into an observation group and a control group after condition assessment, with 25 cases in each group. The results of cholinesterase (ChE), prealbumin (PALB), albumin (ALB), aspartate aminotransferase (AST), total protein (TP), and forced expiratory volume (FEV1)/Predicted (Pred) of the two groups were measured. Results: The ChE levels of the observation group were lower than those of the control group, while the PALB and ALB levels of the observation group were higher than those of the control group (P < 0.05). The AST, TP, and FEV1 /Pred levels of the observation group were higher than those in the control group (P < 0.05). Conclusion: Serum PALB levels can be used as the main indicator for prognosis in critically ill respiratory patients.
Comprehension of the phenomenon of consciousness within the framework of quantum approach (on the example of the concepts of M. Mensky and R. Penrose – S. Hameroff)
Authors: Garifzyanova D. S.
Published: April 2024

The article considers two modern concepts of consciousness: M.  Menski's quantum theory of consciousness and R. Penrose-S. Hameroff's theory  of objective reduction of states. Key aspects of the concept of consciousness  within the framework of quantum approach are identified and both advantages  and disadvantages of each concept are noted. Further prospects for the  development of these concepts are presented, the philosophical analysis of  which, of course, reflects certain trends in the development of modern science.
Digital socialization: children and young people in the modern information space
Authors: Toganova Zh. K. , Syzdykova M. B.
Published: April 2024

This article discusses the issues of digital socialization in detail. In  addition, the analysis of ways and effective ways of support and protection of  children and adolescents in modern information space was carried out, the  behavior formed in the course of digital socialization was determined, and an  algorithm for determining the types of internet users was proposed. The results  of the sociological study allow us to formulate working hypotheses about the  various effects of digital socialization on modern students. The results of the  study can be used in the formation of strategic plans for the development of  the digital sphere and educational policies. The scientific novelty of the study  consists in the development of a new methodological solution for use in the  process of generalizing the socializing influence of the internet environment.  The practice was proved by the types of questionnaires, tests, etc.at the Kyzylorda  higher pedagogical college named after M. Mametova.
Spatial scan statistics and identification of high-risk areas for COVID-19 in the state of Bahia, Brazil
Authors: Marques Bezerra Ronney , Santana Gibson Barros de Almeida Santana , Cavalcanti Leal Thiago , Gomes Santos Lucas , Ferreira Machado Michael , Xavier José Emerson , Fernandes Tânia Rita Moreno de Oliveira Fernandes , Armstrong Anderson da Costa , Dos Santos Allan Dantas , Bezerra-Santos Márcio , Nunes Bruno Eduardo Bastos Rolim , Vieira Santos Giulia , Do-Carmo Rodrigo Feliciano do-Carmo
Published: April 2024

Introduction: The number of COVID-19 cases in Brazil has increased substantially in all regions of the country. The North and Northeastern region of Brazil has been severely affected by COVID-19, with high mortality rates. The first case of COVID-19 in northeastern Brazil was confirmed in the state of Bahia. The state is also the largest in the region in terms of area and population size. The study aimed to analyze the spatial distribution of incidence and mortality rates due to COVID-19 in the state of Bahia, Brazil.

Methods: An observational study was carried out with COVID-19 data accumulated on May 16, 2020. Global and local Moran statistics and spatial scan statistics were used.

Results: Between March 6, 2020 and May 16, 2020 there were 8,288 confirmed cases and 284 deaths (1.9/100,000) of COVID-19 in Bahia state. Over that time frame the incidence risk of disease was 55,7 (95%CI  54,1-58,2) per 100,000 individuals at risk. The mortality rate is 1.9 per 100,000 (95%CI  1,81-1.98). The spatial scan statistics identified five high-risk clusters for incidence rate, among which cluster 1 stood out, with 86 municipalities. This cluster accounts for 85.24% of all cases registered in the state, and it has a RR of 10.6.

Conclusion:  The study showed heterogeneous distribution of occurrence and death in Bahia, with areas of higher relative risk in the east and south. Actions to fight the disease in the state must take into account the risk areas identified in the study.

Keywords: coronavirus; COVID-19; epidemiology; SARS-CoV-2; spatial analysis.
PERAN SEKTOR PERDAGANGAN BESAR DAN ECERAN: REPARASI MOBIL DAN SEPEDA MOTOR DALAM PEREKONOMIAN KOTA MATARAM: ANALISIS INPUT-OUTPUT
Authors: Wibawanindah Nadiani , Basuki Prayitno , Wijimulawiani Baiq Saripta
Published: April 2024

Kota Mataram merupakan salah satu kota yang ada di Provinsi Nusa Tenggara Barat. Pertumbuhan ekonomi Kota Mataram dalam beberapa tahun terakhir cukup stabil. Salah satu sektor yang memiliki kontribusi yang besar dalam PDRB Kota Mataram adalah sektor perdagangan besar dan eceran. Penelitian ini bertujuan untuk mengetahui seberapa besar peran sektor perdagangan besar dan eceran dalam perekonomian Kota Mataram. Metode yang digunakan dalam penelitian ini adalah Analisis Input-Output. Tahapan-tahapan dalam penelitian ini terdiri dari mengupdate tabel IO Provinsi NTB tahun 2016, menyusun tabel input-output Kota Mataram (metode LQ), analisis keterkaitan dan analisis multiplier. Hasil analisis LQ menunjukkan bahwa sektor perdagangan besar dan eceran termasuk dalam sektor basis, karena memiliki nilai LQ yang tinggi (1,426). Hasil analisis keterkaitan antar sektor menunjukkan bahwa sektor perdagangan besar dan eceran termasuk dalam sektor unggulan, karena memiliki angka keterkaitan kedepan dan kebelakang diatas rata-rata (2,106 dan 1,193). Hasil analisis penyebaran menunjukkan bahwa sektor perdagangan besar dan eceran mempunyai peranan sebagai sektor pemimpin, karena memiliki nilai koefisien penyebaran dan kepekaan penyebaran yang tinggi (1,001 dan 1,783). Hasil analisis multiplier output menunjukkan bahwa sektor perdagangan besar dan eceran berpengaruh untuk meningkatkan output bagi sektor lainnya, karena memiliki angka yang cukup tinggi (1,193).
ANÁLISE DA FREQUÊNCIA DE DIAGNÓSTICOS DE HANSENÍASE NO BRASIL EM PACIENTES DO SEXO FEMININO
Authors: Coelho Chrystian Erlon Almeida , Sousa Lucas Santos
Published: April 2024

Introdução: A hanseníase, também conhecida como lepra, é uma doença infecciosa crônica causada
pela bactéria Mycobacterium leprae. Esta patologia afeta principalmente a pele, os nervos periféricos,
FINANCIAMENTO DE SAÚDE NO TRAUMATISMO CRANIOENCEFÁLICO E CIRÚRGICO NO POLITRAUMATIZADO.
Authors: Almeida Fernanda Braga de , Zambon Mayara Crystina Marthos , Santana Milena Alves , Sebba Rogério , Uchôa Semiramis Vitória Da Silva
Published: April 2024

Introdução: Um evento com impacto físico significativo pode levar um paciente ao trauma ou até ao politrauma, que é quando há múltiplos traumas ou lesões graves em diferentes partes do corpo. Além do
Ludicidade no ensino de língua estrangeira
Authors: Ribeiro Poliana da Silva , Barreto Sônia Maria da Costa
Published: April 2024

A publicação oferece algumas sugestões de jogos digitais que contribuem para a aprendizagem da língua inglesa, bem como atividades lúdicas que podem ser facilmente desenvolvidas em salas de aula do ensino fundamental e que podem ser adaptadas de acordo com o ano de escolaridade e características da turma.
PRAÇAS DIGITAIS: A EFETIVIDADE DO ACESSO GRATUITO À INTERNET NAS PRAÇAS DIGITAIS DE FRANCISCO MORATO
Authors: Amado Thiago Campos
Published: April 2024

Combater a vulnerabilidade social por meio de políticas públicas que atendam em diferentes aspectos as necessidades dos cidadãos é inquestionavelmente necessário. Explorando o amplo campo de possibilidades e caminhos a serem traçados para atender essas demandas, será reforçada aqui a tecnologia como uma das principais chaves para o giro na engrenagem do desenvolvimento populacional. A pesquisa aborda o projeto Wifi Livre, realizado pela Prefeitura de Francisco Morato, uma das cidades com o pior IDH (Índice de Desenvolvimento Humano) da região metropolitana de São Paulo. Através do núcleo tecnológico da internet e de uma parceria público privada, a cidade buscou o fornecimento de um acesso gratuito e democrático para todos os munícipes. O artigo analisa os principais pontos do projeto, que fomenta a importância da rede de acesso, possibilitando o atendimento à comunidade de forma inclusiva e acessível. Vale a pena ressaltar que a oferta de internet distribuída em 15 praças espalhadas pela cidade possibilita a troca de informações entre usuário e a gestão pública de forma ainda mais efetiva, de maneira que os serviços públicos digitais oferecidos tenham ampla divulgação e os anseios da população sejam compartilhados diariamente. Neste artigo é avaliada a navegação oferecida para os usuários em três praças digitais, por meio das conexões, abrangência de sinal, velocidade e largura da banda para verificar o pleno atendimento do termo técnico referencial, base do projeto. Esses e outros dados demonstram que o projeto como o Wifi livre traz ganhos diversos à comunidade, que usufrui da inovação da gestão pública por meio da tecnologia.
Teologia da Conversão
Authors: José Henrique
Published: April 2024

A cura de almas extraordinária que se exerce por ocasião das missões paroquiais, tem entre as suas primeiras finalidades a conversão dos pecadores. O zêlo sacerdotal do pároco e dos missionários, dando ao povo o benefício das santas missões, visa a renovação total da vida cristã coletiva, mas procura de um modo particular a conversão dos mais afastados, a volta das ovelhas tresmalhadas que talvez possam ser reconduzidas ao redil do Bom Pastor....
Evaluation of pricing methods and its impact on accessibility to care in public hospitals: Cases of the Makiso and Mangobo General Reference Hospitals from 2019 to 2021
Authors: Gabriel Omari Asaka  , Obed Kasereka Kaniki  , Raymond Assani Ramazani
Published: April 2024

Introduction: In the Democratic Republic of Congo, there are two types of pricing for medical care in hospitals: Flat Rate Pricing and Pricing per Act. This study focuses on the evaluation of pricing methods and its impact on accessibility to care in public hospitals. This study specifically aims to determine the pricing method that allows the GRH/Makiso and the GRH/Mangobo to maximize revenue. Methodology: This is a retrospective analytical study, conducted over a period of three years, i.e. from 2019 to 2021, and which concerned the maximization of revenues in the General Reference Hospitals of Makiso and Mangobo. The documentary analysis allowed us to collect the data and the use of average and percentage calculations made it possible to analyze the data. The comparison of the results was certified by the Chi2 test at the threshold of 0.05. Results: The annual revenues produced by the Pricing per Act at the GRH/Mangobo from 2019 to 2021 are relatively lower than the annual revenues generated by the Flat Rate Pricing at the GRH/Makiso, i.e. respectively, 129,013,100.00 FC, compared to 706,501,460.00 FC. Finally, it is the Flat Rate Pricing which is advantageous for the hospital in being able to maximize revenue. Conclusion: The Congolese State is obliged to finance the health system accordingly to allow public hospitals to operate efficiently. It is therefore up to hospitals to choose the type of pricing that allows them to generate revenue.