bluuebunny/crossref_metadata_2025 huggingface dataset:
The Magnitude of Dexamethasone-Induced Hyperglycemia in Cataract Surgical Patients with Normal Glucose Metabolism- A Continuous Glucose Monitoring Based Study
Authors: Zhang Wen-li , Gao Gu , Sun Xiao-juan , Ye Lei , Ma Jian-hua , Li Feng-fei
Published: September 2020

Background: To determined 24-hrs glycemic variations using continuous glucose monitoring (CGM) in cataract surgical patients with normal glucose metabolism receiving dexamethasone therapy.Methods: This was a single-center, randomized, observational and prospective trial. Between June 2017 and December 2018, cataract surgical patients with normal glucose toleration were recruited, and were randomized assigned at a ratio of 1:2 to either receiving 10 mg dexamethasone daily for 3 days after cataract surgical (dexamethasone group) or without dexamethasone therapy (control group). A retrospective CGM was performed at afternoon on -1 day before cataract operation performed for at least 3 days. The primary endpoint was the difference in mean amplitude of glycemic excursions (MAGE) between the two groups.Results: We observed that patients receiving 10 mg dexamethasone daily showing mild increase in mean glucose and hourly mean glucose throughout 24-hrs compared to control group. We also detected that dexamethasone leading to a significant increase in glycemic variation, in term of standard deviation, and a number increase in MAGE and CV%.Conclusion: Our data reveal that short period administration of dexamethasone leading a mild increase in glycemic variations (GV). However, the increased GV may have not clinically relevant. Our data indicates that short duration of 10 mg dexamethasone once daily may be a safe therapy regarding glycemic metabolism in subjects without diabetes.
Gender Intentional Approaches to Enhance Health Social Enterprises in Africa: A Qualitative Study of Constraints and Strategies
Authors: McKague Kevin , Harrison Sarah , Musoke Jenipher
Published: September 2020

Background: Health social enterprises are experimenting with community health worker (CHW) models that allow for various income-generating opportunities to motivate and incentivize CHWs. Although evidence shows that improving gender equality contributes to the achievement of health outcomes, gender-based constraints faced by CHWs working with social enterprises in Africa have not yet been empirically studied. This study is the first of its kind to address this important gap in knowledge. Methods: We conducted 30 key informant interviews and 21 focus group discussions between 2016 and 2020 (for a total of 175 individuals: 106 women and 69 men) with four health social enterprises in Uganda and Kenya and other related key stakeholders and domain experts. Interview and focus group transcripts were coded according to gender-based constraints and strategies for enhanced performance as well as key sites for intervention. Results: We found that CHW programs can be more gender responsive. We introduce the Gender Integration Continuum for Health Social Enterprises as a tool that can help guide gender equality efforts. Data revealed female CHWs face seven unique gender-based constraints (compared to male CHWs): higher time burden and lack of economic empowerment; risks to personal safety; lack of career advancement and leadership opportunities; lack of access to needed equipment, medicines and transport; lack of access to capital; lack of access to social support and networking opportunities; and insufficient financial and non-financial incentives. Data also revealed four key areas of intervention: the health social enterprise, the CHW, the CHW’s partner, and the CHW’s patients. In each of the four areas, gender responsive strategies were identified to overcome constraints and contribute to improved gender equality and community health outcomes. Conclusions: This is the first study of its kind to identify the key gender-based constraints and gender responsive strategies for health social enterprises in Africa using CHWs. Findings can assist organizations working with CHWs in Africa (social enterprises, governments or non-governmental organizations) to develop gender responsive strategies that increase the gender and health outcomes while improving gender equality for CHWs, their families, and their communities.
Encephalitis Associated with COVID-19 in a Patient with Multiple Sclerosis
Authors: Moghadasi Abdorreza Naser
Published: September 2020

From the beginning of COVID-19 pandemics, the involvement of patient’s nervous system with this virus is increasingly reporting. Although various reports are published on affliction of multiple sclerosis (MS) patients with SARS-CoV-2, no report has been published on brain involvement by this virus in MS patients so far. Herein, a 34-year-old patient with MS who experienced the decreased level of consciousness and encephalopathy following COVID-19 involvement has been reported.
Survival and Analysis for Mixed Medullary-Follicular Thyroid Carcinoma: based on SEER database
Authors: Wan Zheng , Wang Bing , Miao Xin , Chen Zhida , Huang Sisi , Zhang Kai , Tian Wen , Xi Hongqing
Published: September 2020

PurposeDue to lack of proper diagnostic tools, we aimed to establish a nomogram for Mixed Medullary-Follicular Thyroid (MMFTC) and comparison with AJCC staging in prognosis. MethodsData regarding 203 patients with MMFTC (ICD-O-3 codes 8346, 8347) between 2000 and 2016 from The Surveillance, Epidemiology, and End Results (SEER) database. X-tile program was used to evaluate the optimal cut-off values for continuous variables. Univariate and multivariate regression analyses were performed with the Cox proportional hazards regression model to analyze the independent factors related to prognosis. Construct cancer-specific survival (CSS) and overall survival (OS) were analyzed. The resulting values were compared with the nomogram and the American Joint Committee on Cancer (AJCC) staging using C-index, verification curve, internal validation and decision curve analysis (DCA).ResultsThe CSS nomogram presented the prognostic factors including year of diagnosis (p = 0.045), tumor size (p = 0.003), extrathyroidal extension (p = 0.009) and pN stage (p = 0.008), while the OS nomogram showed the prognosis factors including year of diagnosis (p = 0.011), age at diagnosis (p = 0.010), tumor size (p = 0.013), extrathyroidal extension (p = 0.008), pT2 stage (p = 0.021) and Radioactive implants or Radioisotopes (p = 0.031).The C-index, verification curve, internal validation and DCA for these nomograms showed better performance in comparisons with the AJCC staging.ConclusionThe more appropriate and efficient therapeutic strategies were showed by the two nomograms for clinical prediction of OS and CSS in MMFTC.
Receptor-free Discrimination of Peptide Native Bound Conformations Suggests Limited Transferability of the “cen_std+score4l” Rosetta Energy Function From Proteins to Peptides
Authors: Bazzoli Andrea , Contini Alessandro
Published: September 2020

One of the strategies of peptide–protein docking is to pregenerate an ensemble of peptide conformations in the absence of the receptor, and then dock them as rigid bodies onto its surface. Success of this strategy requires that the scoring function that drives the pregeneration step be able to discriminate in favor of conformations that resemble the native bound conformation. Here we present a study on the discrimination of peptide native bound conformations as achieved without receptor by the “cen_std+score4L” Rosetta energy function, a low-resolution scoring function equivalent to one chosen for other tasks where the modeling of solvent effects is of special importance. The cen_std+score4L function was able to assign, on average, lower energies to native-like than to non-native decoy conformations for only 3 of our 18 test peptides; it also ranked one or more native-like decoys in the top 1% for only 2 peptides. However, by optimizing the weights of the energy terms that define the cen_std+score4L function, native discrimination improved substantially: Native-like decoys were assigned lower energies than non-native decoys for 16 peptides, with a discrimination signal larger than noise for 9 peptides, that is, 50% of the test set. And for 9 peptides, too, native-like decoys ranked in the top 1%. An ensuing energetic analysis of native-like versus non-native decoys suggests that native peptide conformations have solvation and non-local electrostatics that poorly recapitulate those of native protein conformations. Native peptide conformations are also characterized by few backbone–backbone H-bonds and by lack of compactness, presumably to optimize interaction with the receptor. Overall, this study lays groundwork for pregenerating dockable peptide conformations with Rosetta, whether the subsequent docking will be performed by Rosetta or some other software.
Morbidity and Mortality Outcomes of Covid-19 Patients With and Without Hypertension in Lagos, Nigeria: A Retrospective Cohort Study
Authors: Osibogun Akin , Abayomi Akin , Kanma-Okafor Oluchi , Idris Jide , Bowale Abimbola , Wright Ololade , Adebayo Bisola , Ogboye Segun , Adeseun Remi , Abdus-Salam Ismael , Mutiu Bamidele , Saka Babatunde , Lajide Dayo , Yenyi Sam , Agbolagorite Rotimi , Onasanya Oluwatosin , Erinosho Eniola , Obasanya Joshua , Adejumo Olu , Adesola Sunday , Oshodi Yewande , Akase IorhenE , Ogunbiyi Shina , Omosun Adenike , Erinoso Femi , Abdur-Razzaq Hussein , Osa Nike , Akinroye Kingsley
Published: September 2020

Background: The current pandemic of coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown epidemiological and clinical characteristics that appear worsened in hypertensive patients with COVID-19. The morbidity and mortality of the disease among hypertensive patients in Africa have yet to be well described.Methods: In this retrospective cohort study all confirmed COVID-19 adult patients (≥18 years of age) in Lagos between February 27 to July 6 2020 were included. Demographic, clinical and outcome data were extracted from electronic medical records of patients admitted at the COVID-19 isolation centers in Lagos. Outcomes included dying or being discharged by July 6, 2020. Variables were compared between hypertensive and non-hypertensives using univariable and multivariable logistic regression, cox regression and Kaplan Meier survival analysis methods to assess hypertension as a risk factor associated with worsened disease severity and death.Results: A total of 2075 adults with COVID-19 were included in this study. The prevalence of hypertension was 17.8% and it was the most common comorbidity followed by diabetes (7.2%) and asthma (2.0%). Overall mortality from COVID-19 was 4.2% while mortality among the hypertensives was 13.7%. Severe symptoms and mortality were significantly higher among the hypertensives and survival rates were significantly lowered by the presence of an additional comorbidity to 50% from 91% for those with hypertension alone and from 98% for all other patients (P<0.001). After adjustment for confounders, severe COVID-19 disease and death were higher for hypertensives (severe/critical illness: HR=2.41, P=0.001, 95%CI=1.4–4.0, death: HR=2.30, P=0.001, 95%CI=1.2–4.6, for those with hypertension only). Hypertension posed an increased risk of severe morbidity and death from coronavirus disease in the presence of other comorbidities (severe/critical illness: HR=3.76, P=0.001, 95%CI=2.1–6.4, death: crude HR=6.63, P=0.001, 95%CI=3.4–1.6, for those with additional comorbidities).Conclusion: The potential morbidity and mortality risks of hypertension especially with other comorbidities in COVID-19 could help direct efforts towards prevention and prognostication. This provides the rationale for improving preventive caution for people with hypertension and other comorbidities and prioritizing them for future antiviral interventions.
Dendrobium officinale Orchid Extract could improve wound healing in diabetic mice
Authors: Zhu Qiang-qiang , Yu Cai-jun , Yang Xiao-ying , Pang Qian-qian , Li Jian-fei , Li Ming-ming , Wang Xuan-jun , Sheng Jun
Published: September 2020

Background

In diabetes, delayed wound healing is one of the most prominent clinical manifestations and lacks satisfactory therapeutic schemes. Persistent inflammation impairs the healing process which occurs in the late phase of wound healing in diabetes mellitus (DM) mice. It has been report that dendrobium officinale (DE) could decrease inflammation and the NF-κB signaling pathway plays a critical role in regulated inflammation. The aim of the present study is to detect whether DE attenuated inflammation by NF-κB to accelerate wound healing in diabetes.
Methods

Mice were induced to diabetes by streptozocin (STZ) for 15 days. Two circular 8-mm full-thickness wounds were created on the back and then received DE treatment for 18 days. The percentage of wound healing, re-epithelialization and collagen deposition were calculation to evaluation the effect of DE on wound healing. The expression levels of interleukin (IL)- 1β and TNF-α in the wound site were determined by WB. Macrophage deposition and the type of macrophage were detected by WB and immunohistochemical staining. In addition, the expression of p65 was detected by WB.
Results

Herein, we observed that the late wound healing could be improved by dendrobium officinale orchid extract (DE) in streptozotocin (STZ)-induced DM mice. The accumulation of collagen was increased by DE treatment in the skin. We also found that the expression of pro-inflammation cytokines IL-1β, and TNF-α were inhibited by DE treatment in the skin wounds of DM mice. Furthermore, the macrophages accumulation which increased in diabetes wound site, were inhibited by DE treatment in the DM mice wound skin. And the CD163 which is a marker of type 2 macrophage was increased by DE treatment. Moreover, we confirmed that DE could decrease the expression of iNos which is a marker of type 1 macrophage by IHC in the skin wounds. And the levels of p65 and p65 phosphorylation were decreased by DE.
Conclusions

Wound healing can be improved by DE through NF-κB signaling pathway to attenuated inflammation in STZ-induced diabetic mice.
Association Between Triglyceride-Glucose Index and Risk of Incident Diabetes: A Secondary Analysis Based on A Chinese Cohort Study
Authors: Li Xiaoli , Li Guilong , Cheng Tiantian , Liu Jing , Song Guangyao , Ma Huijuan
Published: September 2020

Background: Recent studies have suggested the triglyceride-glucose index (TyG index) may serve as a suitable substitute for insulin resistance. However, evidence for the relationship between TyG index and risk of diabetes remains limited. This study sought to explore the association of baseline TyG index with risk of developing diabetes in Chinese adults.Methods: This retrospective cohort study was conducted using data from the health screening program in China. A total of 201,298 non-diabetic individuals were included. TyG index was calculated as Ln [fasting plasma glucose (mg/dl) × fasting triglyceride level (mg/dl)/2]. Diabetes was defined as fasting plasma glucose ≥7.0 mmol/L and/or self-reported diabetes. Cox proportion-hazard model was employed to evaluate the independent impact of baseline TyG index on future diabetes risk. Sensitivity and subgroup analyses were implemented to verify the reliability of results. Notably, data were downloaded from the DATADRYAD website, and used only for secondary analyses.Results: During an average follow-up of 3.12 years, among 201,298 individuals aged ≥20 years, 3,389 subjects developed diabetes. After adjusting for potential confounders, elevated TyG index were independently correlated with greater risk of incident diabetes (hazard ratio (HR), 3.34; 95% confidence interval (CI), 3.11–3.60). Compared with the lowest quartile (Q1), increasing TyG index (Q2, Q3, and Q4) was related to increased HR estimates of incident diabetes [HR (95% CI), 1.83 (1.49–2.26); 3.29 ( 2.70–4.01), and 6.26 (5.15–7.6), respectively]. Moreover, a nonlinear relationship was observed between TyG index and risk of diabetes and the slope of the curve increased accompanying the rise of TyG index. Subgroup analysis revealed the positive association was stronger among subjects with age< 40 years, body mass index ≥18.5 kg/m2 and < 24 kg/m2, or systolic blood pressure <140 mmHg, or in females.Conclusions: Elevated TyG index is independently correlated with increased risk of incident diabetes in Chinese adults, indicating it may represent a reliable predictor of diabetes in high-risk populations.
Assessment of D-dimer for ruling out peripherally inserted central catheter-associated upper extremity venous thrombosis: a diagnostic accuracy study
Authors: Liu Wanli , He Lianxiang , Zeng Wenjing , Yue Liqing , Wei Jie , Zeng Shuangshuang , Wang Xiang , Gong Zhicheng
Published: September 2020

Background: With the extensive use of peripherally inserted central catheter (PICC), PICC-associated venous thrombosis (VT) has become one of the most important complications in the hospital. To reduce unnecessary color Doppler ultrasound (CDU) or imaging tests, D-dimer values are usually used to exclude VT. There is little evidence for the usefulness of the D-dimer level as an independent diagnostic marker for excluding PICC-associated VT.Objectives: To examine the effectiveness of D-dimer concentration to be used as an independent diagnostic marker for excluding PICC-associated UEVT. Design: A retrospective case cohort study. Settings: One teaching hospital in Hunan, China. Participants: In total, 281 subjects who underwent CDU and D-dimer values after PICC placement were eligible.Methods:The patients were categorized into the DVT unlikely group (<2 points) and the DVT likely group (≥2 points) according to their modified Wells score post PICC placement, before extubation. After the Wells score was determined, the patients underwent a D-dimer test and CDU within 7 days after D-dimer test.Results: 281 patients were included in the final analysis. Of them, 180 patients had D-dimer value <0.5 mgL-1. There were 39 patients with upper extremity venous thrombosis identified via CDU and 78.3% with negative predictive value of D-dimer for PICC-associated VT (95% CI: 71.7–83.7%). The negative predictive value of D-dimer for SVT was 91.0% (95% CI: 85.4–94.6%), which was higher than that for DVT (84.9%, 95% CI: 78.7–89.6%) and for VT in the cancer population (80.0%, 95% CI: 73.2–85.4%) and the non-cancer population (60.0%, 95% CI: 35.7–80.2%).Conclusion: the D-dimer concentration should not be used as a diagnostic index to rule out PICC-associated VT to avoid missed diagnosis of PICC-related venous thrombosis, which may cause adverse consequences or may even be life-threatening.
Viral and Bacterial Pneumonia Detection using Artificial Intelligence in the Era of COVID-19
Authors: Ozsoz Mehmet , Ibrahim Abdullahi Umar , Serte Sertan , Al-Turjman Fadi , Yakoi Polycarp Shizawaliyi
Published: September 2020

Background: The outbreak of COVID-19 on the eve of January 2020 has led to global crisis around the world. The disease was declared pandemic by World Health Organization (WHO) in mid-March. Currently the outbreak has affected more than 150 countries with more than 20 million confirmed cases and more than 700,000 death tolls. The standard method for detection of COVID-19 is the Reverse-Transcription Polymerase Chain Reaction (RT-PCR) which is less sensitive, expensive and required specialized health expert. As the number of cases continue to grow, there is high need for developing rapid screening method that is accurate, fast and cheap. Methods: We proposed the use of Deep Learning approach based on Pretrained AlexNet Model for classification of COVID-19, non-COVID-19 viral pneumonia, bacterial pneumonia and normal Chest X-rays Images (CXR) scans obtained from different public databases. Result and Conclusion: For non-COVID-19 viral pneumonia and healthy datasets, the model achieved 94.43% accuracy, 98.19% Sensitivity and 95.78% Specificity. For bacterial pneumonia and healthy datasets, the model achieved 91.43% accuracy, 91.94% sensitivity and 100% Specificity. For COVID-19 pneumonia and healthy CXR images, the model achieved 99.16% accuracy, 97.44% sensitivity and 100% Specificity. For classification of COVID-19 pneumonia and non-COVID-19 viral pneumonia, the model achieved 99.62% accuracy, 90.63% sensitivity and 99.89% Specificity. For multiclass datasets the model achieved 94.00% accuracy, 91.30% sensitivity and 84.78% specificity for COVID-19, bacterial pneumonia and healthy. For 4 classes (COVID-19, non-COVID-19 viral pneumonia, bacterial pneumonia and healthy, the model achieved accuracy of 93.42%, sensitivity of 89.18% and specificity of 98.92%.
Acceleration of Pelvic Tissue Construction by Overexpression of Basic Fibroblast Growth Factor in the Stem Cells
Authors: Wu Xiaotong , Jia Yuanyuan , Wang Shiyan , Wang Jiaqi , Sun Xiuli , Wang Jianliu
Published: September 2020

Background Pelvic organ prolapse (POP) is a common debilitating condition affecting about 30–40% of women. The application of stem cells therapy and growth factor has greatly promoted the development of pelvic tissue engineering, which remains a promising approach, but there is no consensus on the therapeutic mechanism of stem cells and the application of growth factors. Stem cells were mainly used as seed cells to differentiate into target tissue cells, fuse with target tissue after transplantation and paracrine effect to play a therapeutic role in pelvic tissue engineering. However, whether stem cells can be differentiated into target tissue cells is still to be a question,in this regard, the contemporary trend is to investigated the effect of adipose-derived stem cells (ADSCs) as the seed cells of pelvic tissue engineering on the repair of POP and the underlying mechanisms.Methods In the present study,we evaluated the therapeutic potential of gene-modified ADSC that overexpress basic fibroblast growth factor（bFGF）and evaluated its effects on paracrine function and directional differentiation ability.Results The results showed that following ADSCs are designed to continuously release controllable levels of growth factors during the control period of repair, taking advantage of the paracrine function of stem cells to accelerate cell growth and extracellular matrix (ECM) reconstruction during the early stage of stem cell implantation, and then stem cells are differentiated into target tissues-fibroblasts to accelerate the reconstruction of pelvic floor tissues.Conclusions We suggest that the observed effects are determined by pleiotropic effects of bFGF, along with the multifactorial paracrine action of ADSC which remain viable and functionally active within the engineered cell construct.Thus, we demonstrated the high therapeutic potential of the utilized approach for pelvic tissue engineering.
APOE ε4 Allele Modulates The Differential Effects of Education on Cognition in Alzheimer’s Continuum: The SILCODE Study
Authors: Chen Guanqun , Yang Kun , Han Ying
Published: September 2020

Background: Elders with subjective cognitive decline (SCD) in the absence of objective cognitive impairment are at increased risk of developing mild cognitive impairment (MCI) or Alzheimer’s disease (AD). Previous study has reported that higher education was associated with better performance in cognitive performance in elderly people with SCD. However, it is not clear whether there is a differential effect of education on cognition between healthy controls (HC), individuals with SCD and patients with cognitive impairment (CI).Methods: We performed a cross-sectional study that included 186 HC, 279 SCD subjects and 79 patients with CI from the Sino Longitudinal Study on Cognitive Decline (SILCODE) project. A series of neuropsychological tests of memory, executive, language, and general cognitive function were used to assess the subjects cognitive performance. We performed multiple linear regression models to examine the effect of education on neuropsychological test scores in the total sample and then described differences in the effect according to three different groups. In addition, we presented the effect of education on total test score expressed as a global composite z-scores in the total sample and three different groups, respectively. Furthermore, we examined whether apolipoprotein E ε4 allele (APOE ε4) status would regulate the effect of education on the global composite score among three different groups.Results: Education has a positive effect on cognition in the total sample. Stratification for different groups showed that the positive effect of education on cognition is found in HC and SCD group, while education has a negative effect on cognition in the CI group. Furthermore, we found the APOE ε4 allele does not modify the positive effect of education on cognition in the HC group, but the APOE ε4 allele weaken that beneficial effect in the SCD group and maintain the negative effect in the CI group.Conclusions: High education may delay the progression from SCD to cognitive impairment and yield differential effects on cognition across the spectrum of AD. Furthermore, that differential effects are subjected to modulation by the APOE ε4 status.
Modelling the Global Air Quality Conditions in Perspective of COVID-19 Stimulated Lockdown Periods Using Remote Sensing Data
Authors: Talukdar Swapan , Mahato Susanta , Pal Swades , Debanshi Sandipta , Shahfahad  , Das Priyanka , Rahman Atiqur
Published: September 2020

COVID-19 outbreak across the world has invited forced lockdown conditions, which causes a huge economic landslide. But it has brought an opportunity for restoring the environment of its own which may cause ecosystem well-being. Focusing on the second issue, the present work has intended to explore the streams of air quality change based on some quality components and develop a multi-date air quality state (AQS) model for the world in consequence of emergency lockdown. It is very clear from the result that amid lockdown aerosol optical depth (AOD), sulfur dioxide (SO2), ozone, carbon monoxide (CO), particulate matter (PM2.5), and black carbon (BC) concentration level have been significantly reduced in fully lockdown countries. AQS is considerably improved amid lockdown. Hotspots of COVID-19 were under unhealthy, very unhealthy air quality class in pre lockdown condition, but amid lockdown, these countries have been shifted to good and moderate healthy air quality classes
Coronavirus Disease 2019 is Threatening Stroke Care Systems: Challenge and Management
Authors: Xin Jiawei , Huang Xuanyu , Liu Changyun , Huang Yun
Published: September 2020

Background

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, the stroke care systems have been seriously affected because of social restrictions and other reasons. As the pandemic spreads further to global, it is of great significant to understand how COVID-19 affect the stroke care systems.

Methods

We retrospectively studied the real-world data of one comprehensive stroke center in China from January to February, 2020, and compared it with the same period in 2019. We analyzed time from stroke onset to admission, severity, effect after treatment, hospital stays, cost of hospitalization, etc., and correlation among them.

Results

We observed a great extension of the onset-to-door time of stroke patients during the pandemic. The degree of neurological deficit of the patients was significantly higher, both admission and discharge. Longer onset-to-door time and higher degree of neurological deficit were significantly correlated with longer hospital stays and higher medical burden.

Conclusions

COVID-19 pandemic is threatening the stroke care systems. Measures must be taken to minimize the collateral damage caused by COVID-19.
Long Non-Coding RNA BC040587 is Required in Cell Invasion of Renal Cancer Induced by Acidosis
Authors: Zhou Yang , Dong Di , Yao Qin , chen binghai
Published: September 2020

Background: It is well known that aggressive growth and metastasis of tumors are strengthened in acidic environments of cancer. Whether Long non-coding RNA (LncRNA) is involved in this process is still unknown and has never been reported in renal cell cancer(RCC).Methods: We determined the invasion ability of 786-O and 769P cells upon acidosis. Then LncRNA profiling was used to figure out the potential acidosis-related LncRNAs. We then knocked out the LncRNA (BC040587) to investigate its role in acidosis-induced cell invasion. AKT/mTOR ,MEK/ERK pathway as well as pMDM2 were analyzed to uncover the cell signaling induced by BC040587 upon acidosis. Clinical features were also carefully analyzed.Results: Acidosis elevated the level of Snail and induced cell invasions in RCC. BC040587 was required in this process as the increased cell invasion could be abolished by knockout of BC040587. Acidosis activated AKT/mTOR and MEK/ERK pathway in a BC040587-dependent manner. MDM2 could be the downstream of BC040587, which implicated poorer prognosis in RCC based on the clinical features.Conclusions: BC040587 is required in cell invasion of renal cancer induced by acidosis. The BC040587-AKT/ERK-pMDM2-Snail axis is of vital importance in the development of RCC and is likely to be potential therapeutic target in RCC.
A Multi-Epitope Vaccine Against Sars-Cov-2 Directed Towards the Latin American Population: An Immunoinformatics Approach
Authors: Cuspoca Andrés F. , Díaz Laura L. , Acosta Alvaro F. , Peñaloza Marcela K. , Mendez Yardany R. , Clavijo Diana C. , Reyes Juvenal Yosa
Published: September 2020

The coronavirus pandemic is a major public health crisis affecting global health systems with dire socioeconomic consequences, especially in vulnerable regions such as Latin America. There is an urgent need for a vaccine to help control contagion, reduce mortality and alleviate social costs. In this study, we propose a rational multi-epitope vaccine against SARS-CoV-2. Using bioinformatics, we constructed a library of potential vaccine peptides to predict immunological complexes among antigenic, non-toxic and non-allergenic peptides extracted from the conserved regions of 92 proteomes. We included the most common HLA-I and II molecules in the Latin American population. We also used three-dimensional structures of SARS-CoV-2 proteins to identify potential regions for antibody production. The best HLA-I and II predictions (with increased coverage in common alleles and regions evoking B lymphocyte responses) were grouped into an optimised final construct that meets the necessary safety and physicochemical requirements for conducting experimental tests.
Aphelenchus yinyuensis n. sp. (Tylenchina: Aphelenchoididae) found in Terminalia sp. in China
Authors: Jianfeng Gu , Maria Munawar , Fang Yiwu , Lele Liu , Chen Xianfeng , Cai Bo
Published: September 2020

During a nematode biodiversity survey in Hainan Province, China, Aphelenchus yinyuensis n. sp. was detected in the rhizosphere of Terminalia sp. It is characterized by medium-sized a body of adult nematodes, i.e. 793 (639-877) μm and 756 (647-863) μm for females and males, respectively, with low, rounded, not offset lip region. The lateral field has 10 incisures. The excretory pore is located posterior to the nerve ring. The vagina is not sclerotised and the vulva has simple lips without a flap. The PUS is well developed and forms ca 45 to 83% of the vulva to anus distance. Female tail is straight, cylindrical, ca 2.7 times longer than anal body diam, tail tip broad, and bluntly rounded. Males have four pairs of caudal papillae and spicule 28.7 (25.8-32.3) μm long in the chord and well developed bursa, extending to the tail tip. 18S and 28S rRNA phylogenetic analyses were performed for the new species, and the ITS analysis was not performed due to low posterior probability support. Phylogenetically, the new species grouped with Aphelenchus avenae and this is the first new Aphelenchus species ever described from China.
The wealth of nations and sustainable development: energy intensity and the environmental Kuznets curve
Authors: Honningdal Grytten Ola , Lindmark Magnus , Bjørn Minde Kjell
Published: September 2020

Scholars warn that wealth leads to unsustainable environmental development. However, over the last decades, studies have shown an increase in environmental degradation at the initial stage of economic growth, and then a decline when economic growth reaches a certain level. This first acceleration and then deceleration create an inverted U-shaped curve between pollution and economic growth, called the environmental Kuznets curve (EKC). Environmental degradation can be measured by different factors. This paper deals with two of them, i.e. energy consumption and energy intensity (EI). The latter is measured as the ratio between energy consumption and GDP. The relationship of energy consumption and intensity to economic growth can serve as a tool for examining whether an EKC exists. The paper presents continuous series of energy consumption energy intensity and gross domestic product for the Norwegian mainland economy 1835–2019. The series are used to examine the possible existence of relative and absolute environmental Kuznets curves (EKC). Time series are established using available data and annual figures for 1835–2019, which are presented for the first time. They depict a development that, first, reflects an almost constant downward trend in EI, and, second, the existence of EKCs. The paper also proposes a polynomial regression model to discuss the relationship between environmental degradation as measured by energy consumption and intensity on the one hand, and economic growth on the other. It is concluded that there are both relative and absolute EKC-relations between environmental degradation and economic growth, with 1975 as relative and 2002 as absolute turning point.
Disruptive Innovations: A Case of Solving Hoax Information in Indonesia
Authors: Tukina Tukina , Mozin Abd.Razak M , Sanjaya Marta
Published: September 2020

The research discussed hoax information as an effect of disruptive innovation and how to solve it in society. It applied a qualitative descriptive method with a case study focusing on hoax information of 10 million Chinese workers who came to Indonesia. The research was a library research conducted through various sources of literature and journals. Data analysis was carried out by answering the points that were analyzed and cross-checked to other data sources in order to answer the research questions. It is found that living in the millennial changes rapidly; various forms of innovation are born and developed very quickly, and so do the problems and challenges. To prevent the spread of hoax information, some efforts need to be done to understand the process, ethics implementation, law enforcement, and accountability of information.
Filosofia da Educação a Distância
Authors: Figueiredo Nascimento Camila , Esteves dos Santos Maria Emanuela
Published: September 2020

O livro “Filosofia da Educação a Distância: conceitos e concepções” é uma obra organizada pela professora doutora Lílian do Valle em parceria com Estrella Bohadana (in memorian), Sônia Ribeiro e Ana Lúcia Gomes. Trata-se de uma coletânea de textos que exploram conceitos pouco (ou nada) visitados na área da educação a distância (EaD), propondo a reflexão conceitual das noções de presença, distância, interatividade, comunicação, mediação, sujeito, atividade, ação, qualidade e autonomia.
O menino e o mundo
Authors: Cordeiro Andrea , Souza Gizele , Gaspar da Silva Vera Lucia
Published: September 2020

Neste artigo, nos debruçaremos sobre as narrativas de desenraizamento e enfrentamento, abordados na animação “O menino e o mundo” (Brasil- 2013), de Alê Abreu. Nosso objetivo será analisar, na potência desta obra, vestígios de uma infância brasileira presente nos deslocamentos migratórios forçados, na constituição das cidades e suas consequências humanas. O aporte teórico estará alicerçado em Milton Santos com seu olhar sobre as motivações e consequências da mobilidade interna das populações no Brasil e na América Latina; nas análises de Bauman sobre as causas sociais e consequências humanas da errância dos indivíduos no espaço globalizado; e também nas contribuições de Cecconi e Polenghi que apontam o cinema como fonte para os estudos históricos da infância. Como resultado esperamos ampliar o entendimento da presença e papel das infâncias na dinâmica das migrações e da cidade, assinalando também o lugar de O menino e o mundo na história do cinema brasileiro.
Letramento digital no Ensino Superior
Authors: De Assis Maria Paulina , Bianconcini de Almeida Maria Elizabeth
Published: September 2020

Este artigo parte de preocupações a respeito de desafios enfrentados por professores no uso das Tecnologias Digitais de Informação e Comunicação (TDIC) na sala de aula e a apropriação dessas tecnologias nas práticas pedagógicas. Objetivou-se investigar o que existe em publicações internacionais sobre letramento digital (digital literacy) no Ensino Superior, por meio de uma revisão sistemática da literatura. Utilizou-se a base acadêmica Education Resources Information Center (ERIC), com o termo digital literacy no título, publicados em periódicos revisados por pares. A pesquisa foi realizada em março de 2020, quando foram encontrados 41 artigos sobre digital literacy no período entre 2008 e 2019, publicados por pesquisadores de 16 países diferentes, que tratam de temas relacionados a: atividades com recursos imersivos, letramento digital associado a aspectos psicológicos, níveis de letramento digital, impactos de características pessoais na apropriação do letramento digital, metodologias e estratégias para desenvolvimento do letramento digital e propostas teóricas, políticas e reflexões.
Estratégias de governamento sobre sujeitos com deficiência em programas da mídia televisiva
Authors: Sonaglio de Vasconcellos Alice , Belmonte Machado Roseli , Veiga-Neto Alfredo
Published: September 2020

Na Contemporaneidade as pessoas com deficiência circulam em diversos espaços e são objeto de distintos debates. Este artigo tem o objetivo de discutir como alguns programas midiáticos operam modos de subjetivação para conduzir a conduta dos sujeitos telespectadores em relação as pessoas com deficiência. O material de análise é parte de um acompanhamento de dois programas televisivos, Encontro com Fátima Bernardes e Esporte Espetacular, que foram analisados por um ano, totalizando 31 episódios. Para este trabalho abordamos 7 episódios. A análise tem por base os Estudos Foucaultianos em Educação, em especial os conceitos-ferramentas de governamento e modos de subjetivação. Destacamos que a mídia exerce uma condução das condutas dos telespectadores, operando modos de subjetivação por intermédio da participação de pessoas com deficiência. Uma participação que não é desinteressada, mas conexas a modos de compreender a pessoa com deficiência como aquela capaz de se superar constantemente.
Editorial
Authors: De Araújo Marta Maria
Published: September 2020

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Educational Change and NEXTSchool
Authors: Starr Lisa , Levitan Joseph , Butler-Kisber Lynn , Rosenberg Aron , Gold Vanessa , MacCannell Ellen
Published: September 2020

In this paper, we examine the current literature on whole-school-system change processes, and the ways in which research findings may be applied to schools in Quebec, Canada. Throughout the paper we use a current school change initiative, NEXTschool, to explore the possibilities and challenges that some of this literature presents, applied to a specific context. At the conclusion we offer a conceptual framework that underpins how we conceptualize the NEXTSchool initiative. The review focuses on three fields that have emerged as relevant to current change movements: 21st century educational change/reform, power dynamics, and design thinking as a systems-change process.
Teaching Science with Intention and Connection
Authors: Tan Poh , Gluck Eduardo
Published: September 2020

This article focuses on teaching science through Vision I, Vision II and Vision III which is an increasingly important but understudied aspect of science literacy. Dr. Poh Tan and Eduardo Gluck, interviewed Clarah Menezes, an elementary school teacher in Novo Hamburgo in Southern Brazil. Clarah teaches Grades 4-5 within a marginalized community and most of her students have varied levels of literacy and numeracy. Dr. Tan visited Clarah when she went to Brazil in 2018 as a visting scholar. Dr. Tan and Clarah have been working together for the past year on disrupting traditional approaches to teaching science. Clarah’s new approach to teaching science is built on Dr. Tan’s framework that builds upon Roberts and Bybee’s attributes of a scientifically literate person.  Dr. Tan’s framework includes a perspective of teaching science from a relational and more than human connection with entities, including animals, nature and material. In this interview, Clarah shares her experiences, struggles and insights into teaching science by applying the three-vision framework.
Towards a New Teaching Approach for Scientific Literacy
Authors: Tan Poh
Published: September 2020

Through the three-visions framework, a science educator approaches her science lessons and her practice from a more purposeful and intentional place and building and understanding the relation to the subject of study beyond an objective view can potentially bring more meaningful learning for the students.
Ecosistema global del emprendedor desde una perspectiva financiera y tecnológica
Authors: Rodríguez García Martha del Pilar
Published: September 2020

Esta investigación tiene como objetivo realizar una comparativa del ecosistema emprendedor, financiero y tecnológico entre países desarrollados y emergentes. El estudio considera una muestra de 43 países y los años 2006 y 2018. Para la medición del ecosistema usamos el Índice de Emprendedor Global. Para realizar el análisis se selecciona el método no paramétrico de Vecindades Cercanas. Los hallazgos muestran que los ecosistemas globales permanecen sin cambios en el tiempo. En el ecosistema financiero y tecnológico durante el periodo de estudio, países líderes y niveles inferiores de emprendimiento se mantienen con pocos cambios. Debido a lo estático de los ecosistemas, las políticas públicas y privadas, como cambios cultures, inversión en infraestructura financiera y tecnología deben ser canalizadas a los emprendedores independientemente del país en donde surja el emprendimiento. Las limitaciones que presentaron es poca muestra de países en África en donde es necesario que surjan los emprendimientos para la mejora del bienestar en su población. La metodología de Vecindades Cercanas nos ayuda a analizar diferencias entre países emergentes y desarrollados, lo que nos permite arrojar conclusiones en política económica.
Granger revisited: t values and the empirical OLS bias with stationary and non-stationary time series using Monte Carlo simulations
Authors: Guerrero de Lizardi Carlos
Published: September 2020

La realización de un análisis estadístico confiable se fundamenta en el reconocimiento de las características estadísticas de las series de tiempo en juego y de los supuestos probabilísticos subyacentes del modelo aplicado. Nuestro propósito es ilustrar este tipo de análisis utilizando algunas ideas de Granger. Nuestros resultados de Monte Carlo muestran que en presencia de series de tiempo estacionarias y no estacionarias, la inferencia basada en los mínimos cuadrados ordinarios puede ser engañosa. Abordamos gráficamente la distribución empírica del sesgo del estimador y el inconveniente del uso de errores estándar que subestiman su verdadera variación. Recomendaremos seguir las sugerencias de Granger, que destacamos con originalidad utilizando una perspectiva desde la “medición en economía”. Nuestros ejercicios cuantitativos son replicables en la medida en que compartimos completamente nuestros códigos y utilizamos la base de datos de acceso abierto del documento seminal escrito por Nelson y Plosser (1982). Nuestra conclusión principal es simple: los investigadores empíricos deben ser absolutamente cautelosos al momento de extraer conclusiones cualitativas basadas en una inferencia estándar de mínimos cuadrados ordinarios realizada en el contexto de un análisis de regresión.
The Use of Mumsnet by Parents of Young People With Mental Health Needs: Qualitative Investigation
Authors: Croucher Lauren , Mertan Elif , Shafran Roz , Bennett Sophie D
Published: September 2020

Background

There are high rates of mental health needs in children in the United Kingdom, and parents are increasingly seeking help for their children's needs. However, there is not enough access to child and adolescent mental health services and parents are seeking alternative forms of support and information, often from web-based sources. Mumsnet is the largest web-based parenting forum in the United Kingdom, which includes user-created discussions regarding child mental health.

Objective

This qualitative investigation aimed to explore the emergent themes within the narratives of posts regarding child mental health on Mumsnet and to extrapolate these themes to understand the purpose of Mumsnet for parents of children and young people with mental health needs.

Methods

A total of 50 threads from Mumsnet Talk Child Mental Health were extracted. Following the application of inclusion and exclusion criteria, 41 threads were analyzed thematically using the framework approach, a form of qualitative thematic analysis.

Results

In total, 28 themes were extracted and organized into 3 domains. These domains were emotional support, emotional expression, and advice and information. The results suggested that parents of children with mental health needs predominantly use Mumsnet to offer and receive emotional support and to suggest general advice, techniques, and resources that could be applied outside of help from professional services.

Conclusions

This paper discusses the future of health information seeking. Future research is required to establish initiatives in which web-based peer-to-peer support and information can supplement professional services to provide optimum support for parents of children with mental health needs.