bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S6 from ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis
Authors: Rodriguez Calleja Lidia , Jacques Camille , Lamoureux François , Baud'huin Marc , Tellez Gabriel Marta , Quillard Thibaut , Sahay Debashish , Perrot Pierre , Amiaud Jerome , Charrier Celine , Brion Regis , Lecanda Fernando , Verrecchia Franck , Heymann Dominique , Ellisen Leif W. , Ory Benjamin
Published: March 2023

miR-527 and miR-665 regulate metastasis dissemination in vivo.
Supplementary Figure S5 from ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis
Authors: Rodriguez Calleja Lidia , Jacques Camille , Lamoureux François , Baud'huin Marc , Tellez Gabriel Marta , Quillard Thibaut , Sahay Debashish , Perrot Pierre , Amiaud Jerome , Charrier Celine , Brion Regis , Lecanda Fernando , Verrecchia Franck , Heymann Dominique , Ellisen Leif W. , Ory Benjamin
Published: March 2023

p63 induces TGFÎ²-mediated metastasis in vivo.
Supplementary Figure S3 from H3K27 Demethylase JMJD3 Employs the NF-κB and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis
Authors: Park Woo-Yong , Hong Beom-Jin , Lee Jungsul , Choi Chulhee , Kim Mi-Young
Published: March 2023

JMJD3 upregulates CCL2 and TFPI2 by activating the BMP pathway.
Supplementary Figure S4 from ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis
Authors: Rodriguez Calleja Lidia , Jacques Camille , Lamoureux François , Baud'huin Marc , Tellez Gabriel Marta , Quillard Thibaut , Sahay Debashish , Perrot Pierre , Amiaud Jerome , Charrier Celine , Brion Regis , Lecanda Fernando , Verrecchia Franck , Heymann Dominique , Ellisen Leif W. , Ory Benjamin
Published: March 2023

The p63 and p73-controlled miR network regulates TGFÎ² induced migration.
Supplementary Figure S2 from CRLX101, a Nanoparticle–Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1α
Authors: Tian Xi , Nguyen Minh , Foote Henry P. , Caster Joseph M. , Roche Kyle C. , Peters Christian G. , Wu Pauline , Jayaraman Lata , Garmey Edward G. , Tepper Joel E. , Eliasof Scott , Wang Andrew Z.
Published: March 2023

Evaluation of skin toxicity following drug with radiation (XRT) treatment. (A) Representative images and (B) quantification of skin toxicities observed in animals 49 days following treatment with PBS (Control), CPT, or CRLX101 with radiation.
Supplementary Figure S1 from CRLX101, a Nanoparticle–Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1α
Authors: Tian Xi , Nguyen Minh , Foote Henry P. , Caster Joseph M. , Roche Kyle C. , Peters Christian G. , Wu Pauline , Jayaraman Lata , Garmey Edward G. , Tepper Joel E. , Eliasof Scott , Wang Andrew Z.
Published: March 2023

There is a linear relationship between the number of HT-29-Luc2 cells and the luminescence intensity.
Supplemental Figure S2 from MFG-E8 Drives Melanoma Growth by Stimulating Mesenchymal Stromal Cell–Induced Angiogenesis and M2 Polarization of Tumor-Associated Macrophages
Authors: Yamada Kazuya , Uchiyama Akihiko , Uehara Akihito , Perera Buddhini , Ogino Sachiko , Yokoyama Yoko , Takeuchi Yuko , Udey Mark C. , Ishikawa Osamu , Motegi Sei-ichiro
Published: March 2023

This file contains two supplementary figure S2. from Supplemental Figure S2: A. The amount of CD68+ macrophages in melanoma tumor in mice treated with clodronate liposomes or control liposomes. B. Survival in mice implanted with melanoma cells and MFG-E8 WT/KO MSC treated with clodoronate liposomes or control liposomes.
Supplemental Figure 2 from SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation
Authors: Bilir Birdal , Osunkoya Adeboye O. , Wiles W. Guy , Sannigrahi Soma , Lefebvre Veronique , Metzger Daniel , Spyropoulos Demetri D. , Martin W. David , Moreno Carlos S.
Published: March 2023

Supplemental Figure 2 Figure S2. Probasin-Cre mice (3) obtained from the NCI mouse repository were crossed to ROSA-lox-stop-lox-GFP mice (C57/BL6;129-ROSA26-Lox-Stop-Lox-EGFP (Charles River Laboratories)). Tissues were harvested from male mice after reaching sexual maturity at 8 weeks of age. GFP imaging of organs was performed on an Olympus OV-100 In Vivo Imaging System. Representative tissues from double transgenic mice are shown on the left, and from control mice on the right. Strong GFP signal was detected in pancreas and all three lobes of the prostate.
Supplementary table from CK2α' Drives Lung Cancer Metastasis by Targeting BRMS1 Nuclear Export and Degradation
Authors: Liu Yuan , Amin Elianna B. , Mayo Marty W. , Chudgar Neel P. , Bucciarelli Peter R. , Kadota Kyuichi , Adusumilli Prasad S. , Jones David R.
Published: March 2023

Patient Demographics for TMA.
Supplementary Figure Legends from Activation of the Lin28/let-7 Axis by Loss of ESE3/EHF Promotes a Tumorigenic and Stem-like Phenotype in Prostate Cancer
Authors: Albino Domenico , Civenni Gianluca , Dallavalle Cecilia , Roos Martina , Jahns Hartmut , Curti Laura , Rossi Simona , Pinton Sandra , D'Ambrosio Gioacchino , Sessa Fausto , Hall Jonathan , Catapano Carlo V. , Carbone Giuseppina M.
Published: March 2023

Legend for Supplementary Figures S1-S8.
Supplementary Table 3 from Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival
Authors: den Hollander Petra , Rawls Kathryn , Tsimelzon Anna , Shepherd Jonathan , Mazumdar Abhijit , Hill Jamal , Fuqua Suzanne A.W. , Chang Jenny C. , Osborne C. Kent , Hilsenbeck Susan G. , Mills Gordon B. , Brown Powel H.
Published: March 2023

Supp Tab 3 - Excel spreadsheet containing gene list used to identify phosphatases and phosphatase-interacting proteins.
Supplementary Figure 3 from Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition
Authors: Herkert Barbara , Kauffmann Audrey , Mollé Sandra , Schnell Christian , Ferrat Thomas , Voshol Hans , Juengert Janina , Erasimus Hélène , Marszalek Grégory , Kazic-Legueux Malika , Billy Eric , Ruddy David , Stump Mark , Guthy Daniel , Ristov Mitko , Calkins Keith , Maira Sauveur-Michel , Sellers William R. , Hofmann Francesco , Hall Michael N. , Brachmann Saskia M.
Published: March 2023

Despite major dependence of PTENLOF/BRAFMUT melanoma cell lines on PI3Kβ, PI3Kαi synergizes with PI3Kβi to inhibit downstream signaling upon long-term treatment. A) +B) Effects of treatment with the indicated inhibitors as single-agents or in combination for 2h (A) and 72h (B) on PI3K signaling was determined by immunoblotting in PTENLOF/BRAFMUT melanoma cell lines. PI3Kβi=rac-KIN-193, PI3Kαi=BYL719, PI3Kδi=CAL101
Supplementary Figure 2 from Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition
Authors: Herkert Barbara , Kauffmann Audrey , Mollé Sandra , Schnell Christian , Ferrat Thomas , Voshol Hans , Juengert Janina , Erasimus Hélène , Marszalek Grégory , Kazic-Legueux Malika , Billy Eric , Ruddy David , Stump Mark , Guthy Daniel , Ristov Mitko , Calkins Keith , Maira Sauveur-Michel , Sellers William R. , Hofmann Francesco , Hall Michael N. , Brachmann Saskia M.
Published: March 2023

PI3Kβ inhibition induces p85/IRS2 interaction in a time-dependent manner in the PTENLOF/BRAFMUT melanoma cell line RVH-421 that is mediated by negative feedback signaling. A) Co-immunoprecipitation experiments were carried out using cell lysates of RVH-421 treated with the PI3Kbi for the indicated time and blotted for p85, and pTyr (IRS2). B)-D) Input lysates of the immunoprecipitation experiments shown in Figure 4 were immunoblotted with the indicated phospho-specific or total target protein antibodies. PI3Kβi=rac-KIN-193, mTORi=AZD8055, mTORCi=RAD001, PDK1i=GSK-2334470, AKTi=MK2206
Supplemental Figure Legend from Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival
Authors: den Hollander Petra , Rawls Kathryn , Tsimelzon Anna , Shepherd Jonathan , Mazumdar Abhijit , Hill Jamal , Fuqua Suzanne A.W. , Chang Jenny C. , Osborne C. Kent , Hilsenbeck Susan G. , Mills Gordon B. , Brown Powel H.
Published: March 2023

Supplemental Figure Legend
Table S8 from Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas
Authors: Henrich Kai-Oliver , Bender Sebastian , Saadati Maral , Dreidax Daniel , Gartlgruber Moritz , Shao Chunxuan , Herrmann Carl , Wiesenfarth Manuel , Parzonka Martha , Wehrmann Lea , Fischer Matthias , Duffy David J. , Bell Emma , Torkov Alica , Schmezer Peter , Plass Christoph , Höfer Thomas , Benner Axel , Pfister Stefan M. , Westermann Frank
Published: March 2023

Genes whose hypermethylation and downregulation are associated with high-risk disease (HyperDownHR) are de-repressed upon combination treatment with epigenetically active drugs
Table S5 from Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas
Authors: Henrich Kai-Oliver , Bender Sebastian , Saadati Maral , Dreidax Daniel , Gartlgruber Moritz , Shao Chunxuan , Herrmann Carl , Wiesenfarth Manuel , Parzonka Martha , Wehrmann Lea , Fischer Matthias , Duffy David J. , Bell Emma , Torkov Alica , Schmezer Peter , Plass Christoph , Höfer Thomas , Benner Axel , Pfister Stefan M. , Westermann Frank
Published: March 2023

Genes whose hypermethylation and downregulation are associated with high-risk disease (HyperDownHR) are repressed by MYCN in vitro
Supplementary Methods and References from Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas
Authors: Henrich Kai-Oliver , Bender Sebastian , Saadati Maral , Dreidax Daniel , Gartlgruber Moritz , Shao Chunxuan , Herrmann Carl , Wiesenfarth Manuel , Parzonka Martha , Wehrmann Lea , Fischer Matthias , Duffy David J. , Bell Emma , Torkov Alica , Schmezer Peter , Plass Christoph , Höfer Thomas , Benner Axel , Pfister Stefan M. , Westermann Frank
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplemental Figure 8 from Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity
Authors: Kim Dong Joon , Roh Eunmiri , Lee Mee-Hyun , Oi Naomi , Lim Do Young , Kim Myoung Ok , Cho Yong-Yeon , Pugliese Angelo , Shim Jung-Hyun , Chen Hanyong , Cho Eun Jin , Kim Jong-Eun , Kang Sun Chul , Paul Souren , Kang Hee Eun , Jung Ji Won , Lee Sung-Young , Kim Sung-Hyun , Reddy Kanamata , Yeom Young Il , Bode Ann M. , Dong Zigang
Published: March 2023

The effect of polyamine depletion with herbacetin on cancer cell doubling time. Colon cancer cells were stably transfected with shControl, shODC, Mock or SAT1. (A-B) The effect of herbacetin on HCT116 or HT29 colon cancer cell doubling time was assessed in shControl and shODC cells. (C-D) The effect of herbacetin on HCT116 or HT29 colon cancer cell doubling time was assessed in Mock and SAT1 cells. All data are represented as mean values {plus minus} S.D. of triplicate values from 3 independent experiments. The asterisk (*) indicates a significant effect (p < 0.05) of herbacetin compared to untreated controls.
Supplemental Figure 5 from Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity
Authors: Kim Dong Joon , Roh Eunmiri , Lee Mee-Hyun , Oi Naomi , Lim Do Young , Kim Myoung Ok , Cho Yong-Yeon , Pugliese Angelo , Shim Jung-Hyun , Chen Hanyong , Cho Eun Jin , Kim Jong-Eun , Kang Sun Chul , Paul Souren , Kang Hee Eun , Jung Ji Won , Lee Sung-Young , Kim Sung-Hyun , Reddy Kanamata , Yeom Young Il , Bode Ann M. , Dong Zigang
Published: March 2023

The effect of herbacetin on AP-1 upstream proteins. Colon cancer cells were treated with herbacetin for 48 h and expression of total and phosphorylated ERKs and RSK and total ODC was determined by Western blotting. Beta-Actin was used as a loading control. Similar results were obtained from 3 independent experiments and representative blots are shown.
Supplemental Figure 4 from Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity
Authors: Kim Dong Joon , Roh Eunmiri , Lee Mee-Hyun , Oi Naomi , Lim Do Young , Kim Myoung Ok , Cho Yong-Yeon , Pugliese Angelo , Shim Jung-Hyun , Chen Hanyong , Cho Eun Jin , Kim Jong-Eun , Kang Sun Chul , Paul Souren , Kang Hee Eun , Jung Ji Won , Lee Sung-Young , Kim Sung-Hyun , Reddy Kanamata , Yeom Young Il , Bode Ann M. , Dong Zigang
Published: March 2023

The effect of herbacetin on cell cycle. The effect of herbacetin or DFMO on cell cycle was determined using HCT116, DLD1 or HT29 colon cancer cells. Cells were treated with herbacetin or DFMO for 48 h in medium supplemented with 10% FBS and then cells were serum starved for 24 h in medium supplemented with 0.5% FBS. Cells were stained with propidium iodide (PI) and cell cycle was analyzed by Fluorescence Activated Cell Sorting (FACS). All data are represented as mean values {plus minus} S.D. of triplicate values from 3 independent experiments. The asterisk (*) indicates a significant effect (p < 0.05) of herbacetin or DFMO compared to untreated control.
Supplementary Figure S5 from Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma
Authors: Takayama Yusuke , Hattori Noboru , Hamada Hironobu , Masuda Takeshi , Omori Keitaro , Akita Shin , Iwamoto Hiroshi , Fujitaka Kazunori , Kohno Nobuoki
Published: March 2023

PAI-1 expression in intrapleural tumors consisting of EHMES-10 or MSTO-211H cells
Supplemental Table 3 from G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program
Authors: Yim Christina Y. , Sekula David J. , Hever-Jardine Mary P. , Liu Xi , Warzecha Joshua M. , Tam Janice , Freemantle Sarah J. , Dmitrovsky Ethan , Spinella Michael J.
Published: March 2023

Inivariant Cox proportional analysis for replace/recurrence free survival in breast cancer with high G0S2
Supplemental Table 2 from G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program
Authors: Yim Christina Y. , Sekula David J. , Hever-Jardine Mary P. , Liu Xi , Warzecha Joshua M. , Tam Janice , Freemantle Sarah J. , Dmitrovsky Ethan , Spinella Michael J.
Published: March 2023

Expression of G0S2 in breast cancer versus normal breast tissue
Supplementary Figure 2 from Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients
Authors: Osman Abdullah A. , Neskey David M. , Katsonis Panagiotis , Patel Ameeta A. , Ward Alexandra M. , Hsu Teng-Kuei , Hicks Stephanie C. , McDonald Thomas O. , Ow Thomas J. , Alves Marcus Ortega , Pickering Curtis R. , Skinner Heath D. , Zhao Mei , Sturgis Eric M. , Kies Merrill S. , El-Naggar Adel , Perrone Federica , Licitra Lisa , Bossi Paolo , Kimmel Marek , Frederick Mitchell J. , Lichtarge Olivier , Myers Jeffrey N.
Published: March 2023

Supplementary Figure 2: TP53 knockdown illustrates both loss and gain of function in vitro in HNSCC cells.
Supplemental Table 3 from Jak1–STAT3 Signals Are Essential Effectors of the USP6/TRE17 Oncogene in Tumorigenesis
Authors: Quick Laura , Young Robert , Henrich Ian C. , Wang Xiaoke , Asmann Yan W. , Oliveira Andre M. , Chou Margaret M.
Published: March 2023

NF dataset p< 0.05
Supplemental Figure 3 from Jak1–STAT3 Signals Are Essential Effectors of the USP6/TRE17 Oncogene in Tumorigenesis
Authors: Quick Laura , Young Robert , Henrich Ian C. , Wang Xiaoke , Asmann Yan W. , Oliveira Andre M. , Chou Margaret M.
Published: March 2023

Jak1 qPCR
Supplementary Methods from Downregulation of the TGFβ Pseudoreceptor BAMBI in Non–Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion
Authors: Marwitz Sebastian , Depner Sofia , Dvornikov Dmytro , Merkle Ruth , Szczygieł Magdalena , Müller-Decker Karin , Lucarelli Philippe , Wäsch Marvin , Mairbäurl Heimo , Rabe Klaus F. , Kugler Christian , Vollmer Ekkehard , Reck Martin , Scheufele Swetlana , Kröger Maren , Ammerpohl Ole , Siebert Reiner , Goldmann Torsten , Klingmüller Ursula
Published: March 2023

Description of additional methods and procedures used in the study.
Figure S6 from S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase
Authors: Rizza Salvatore , Montagna Costanza , Cardaci Simone , Maiani Emiliano , Di Giacomo Giuseppina , Sanchez-Quiles Virginia , Blagoev Blagoy , Rasola Andrea , De Zio Daniela , Stamler Jonathan S. , Cecconi Francesco , Filomeni Giuseppe
Published: March 2023

Meta-analysis of the association between GSNOR expression and HCC.
Supplemental Tables S1-S2 from Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation
Authors: D'Armiento Jeanine , Shiomi Takayuki , Marks Sarah , Geraghty Patrick , Sankarasharma Devipriya , Chada Kiran
Published: March 2023

Tsc2+/- extra-renal tumorigenesis is HMGA2 dependent (S1); Summary of human AML LOH analysis (S2).
Supplemental figure and table legends from Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages
Authors: Zhao Jun-Long , Huang Fei , He Fei , Gao Chun-Chen , Liang Shi-Qian , Ma Peng-Fei , Dong Guang-Ying , Han Hua , Qin Hong-Yan
Published: March 2023

Legend for Supplemental Figures S1-S14 and for Supplemental Tables S1-S2.
Supplementary Figure S2 from Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models
Authors: O'Connor James P.B. , Boult Jessica K.R. , Jamin Yann , Babur Muhammad , Finegan Katherine G. , Williams Kaye J. , Little Ross A. , Jackson Alan , Parker Geoff J.M. , Reynolds Andrew R. , Waterton John C. , Robinson Simon P.
Published: March 2023

Validation of R1 measurement accuracy
Supplemental Figures and Table 1 from Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease
Authors: Murphy Stephen J. , Hart Steven N. , Halling Geoffrey C. , Johnson Sarah H. , Smadbeck James B. , Drucker Travis , Lima Joema Felipe , Rohakhtar Fariborz Rakhshan , Harris Faye R. , Kosari Farhad , Subramanian Subbaya , Petersen Gloria M. , Wiltshire Timothy D. , Kipp Benjamin R. , Truty Mark J. , McWilliams Robert R. , Couch Fergus J. , Vasmatzis George
Published: March 2023

Supplemental Table 1 and Figures 1-5 combined in single PDF file. Supplemental Table 1: Mate Pair sequencing data statistics. Supplemental Figure 1: KRAS Mutations in PDAC tumors. Supplemental Figure 2: Frequency copy number plots at the SMAD4 locus (A), chromosome 18 (B), FHIT (C), ZNF521 (D) loci in the primary PDAC tumors and for SMAD4, FHIT and ZNF521 in the PDX tumors (E). Supplemental Figure 3: Expression level changes of commonly hit genes. Supplemental Figure 4: TGFbeta responsive genes. Supplemental Figure 5: FHIT pathway genes and signaling networks.
Supplementary Table S4 from Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications
Authors: Popova Tatiana , Manié Elodie , Boeva Valentina , Battistella Aude , Goundiam Oumou , Smith Nicholas K. , Mueller Christopher R. , Raynal Virginie , Mariani Odette , Sastre-Garau Xavier , Stern Marc-Henri
Published: March 2023

The list of genes differentially expressed in CDK12 inactivated tumors (raw p-values are shown)
Supplementary Tables 1 through 3, Supplementary Figures 1 through 10 from Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition
Authors: Bräutigam Lars , Pudelko Linda , Jemth Ann-Sofie , Gad Helge , Narwal Mohit , Gustafsson Robert , Karsten Stella , Carreras Puigvert Jordi , Homan Evert , Berndt Carsten , Berglund Ulrika Warpman , Stenmark Pål , Helleday Thomas
Published: March 2023

Table S1: The redox status of the cell correlates with sensitivity to MTH1 inhibition. Table S2: Data collection and refinement statistics. Table S3: Kinetic parameters of zfMTH1. Table S4: Primer sequences. Figure S1: BSO treatment sensitizes U2OS and U343 cells against MTH1 inhibition. Figure S2: pre-treatment with PEG-catalase protects cancer cells against MTH1 inhibition. Figure S3: Alignment of human and zebrafish MTH1. Figure S4: Purification of zebrafish MTH1. Figure S5: Electron density for TH588 in the structure of Zebrafish MTH1. Figure S6: knock-down of VHL in HAEB cells sensitizes to the MTH1 inhibitor TH588. Figure S7: TH588 is well tolerated of zebrafish embryos. Figure S8: Expression of MTH1 in VHL knock-out background. Figure S9: Experimental setup for DMOG exposure of zebrafish embryos. Figure S10: ZebROS exposed to reducing and oxidizing agent.
Supplementary Figure S8 from miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3
Authors: Zhou Ying , Dang Jason , Chang Kung-Yen , Yau Edwin , Aza-Blanc Pedro , Moscat Jorge , Rana Tariq M.
Published: March 2023

LAMA3 and LAMC2 Expression Do Not Predict Survival of NSCLC Patients with Tumors Expressing a KRAS Gene Signature.
Supplementary Figure S7 from miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3
Authors: Zhou Ying , Dang Jason , Chang Kung-Yen , Yau Edwin , Aza-Blanc Pedro , Moscat Jorge , Rana Tariq M.
Published: March 2023

siRNA-Mediated Knockdown of KRAS or Overexpression of KRASG12V Has No Effect on FAK mRNA Levels in NSCLC Lines.
Supplementary Figures from Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications
Authors: Popova Tatiana , Manié Elodie , Boeva Valentina , Battistella Aude , Goundiam Oumou , Smith Nicholas K. , Mueller Christopher R. , Raynal Virginie , Mariani Odette , Sastre-Garau Xavier , Stern Marc-Henri
Published: March 2023

22 Supplementary Figures: CDK12 mutations detected in TCGA (S1-2) and in-house (S3) tumors; TDs in CDK12-mutated tumors (S4); Microhomology at the breakpoints and the size of TDs in CDK12-mutated tumors (S5); Copy number alteration profiles of eaPEO14 and PEO14 samples (S6); CDK12 mutation in PD3722a sample (S7); TDs in 25 TCGA cases with WGS (S8); Tumors with frequent TDs in the TCGA cohorts (S9); TD-plus phenotype in breast and prostate cancers (S10); GC content and mutation rate in TDs (S11); Recurrence analysis of TDs (S12); Replication time and CTCF binding sites at TDs (S13). TDs and gene loci (S14); Genomic signatures of HRD and CDK12 TD-plus phenotype (S15); Copy number profiles in tumors with CDK12 TD-plus phenotype (S16); CDK12 mutated tumors and mesenchymal subtype (S17); Molecular features of tumors with CDK12 TD plus phenotype (S18); Genes correlated to CDK12 (S19); Expression of ATM and CSTF3 and RPRD1A in a CDK12 context (S20); Alteration profiles of SKOV3 cell line (S21); The size of microhomology at the breakpoint junctions (S22).
Supplementary Figure Legend from Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications
Authors: Popova Tatiana , Manié Elodie , Boeva Valentina , Battistella Aude , Goundiam Oumou , Smith Nicholas K. , Mueller Christopher R. , Raynal Virginie , Mariani Odette , Sastre-Garau Xavier , Stern Marc-Henri
Published: March 2023

Legends of the 22 Supplementary Figures
Supplementary Figure S5 from miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3
Authors: Zhou Ying , Dang Jason , Chang Kung-Yen , Yau Edwin , Aza-Blanc Pedro , Moscat Jorge , Rana Tariq M.
Published: March 2023

miR-1298-TRAP Crosslinking by UVA Treatment.
Supplementary Figure S1 from miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3
Authors: Zhou Ying , Dang Jason , Chang Kung-Yen , Yau Edwin , Aza-Blanc Pedro , Moscat Jorge , Rana Tariq M.
Published: March 2023

Isogenic HCT116 Cell Lines Show Differential Sensitivity to KRAS Silencing.
Supplemental Materials and Methods from PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Authors: Hein Ashley L. , Seshacharyulu Parthasarathy , Rachagani Satyanarayana , Sheinin Yuri M. , Ouellette Michel M. , Ponnusamy Moorthy P. , Mumby Marc C. , Batra Surinder K. , Yan Ying
Published: March 2023

Description of additional details of materials and methodologies used in this study
Supplemental Figure Legends from PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Authors: Hein Ashley L. , Seshacharyulu Parthasarathy , Rachagani Satyanarayana , Sheinin Yuri M. , Ouellette Michel M. , Ponnusamy Moorthy P. , Mumby Marc C. , Batra Surinder K. , Yan Ying
Published: March 2023

Legends for Supplementary Figures S1-S4
Supplementary Material and Methods from EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor
Authors: Jia Yong , Juarez Jose , Li Jie , Manuia Mari , Niederst Matthew J. , Tompkins Celin , Timple Noelito , Vaillancourt Mei-Ting , Pferdekamper AnneMarie Culazzo , Lockerman Elizabeth L. , Li Chun , Anderson Jennifer , Costa Carlotta , Liao Debbie , Murphy Eric , DiDonato Michael , Bursulaya Badry , Lelais Gerald , Barretina Jordi , McNeill Matthew , Epple Robert , Marsilje Thomas H. , Pathan Nuzhat , Engelman Jeffrey A. , Michellys Pierre-Yves , McNamara Peter , Harris Jennifer , Bender Steven , Kasibhatla Shailaja
Published: March 2023

This file contains additional Materials and Methods that are not listed in the main text.
Supplementary Table I and II from PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer
Authors: Nagarsheth Nisha , Peng Dongjun , Kryczek Ilona , Wu Ke , Li Wei , Zhao Ende , Zhao Lili , Wei Shuang , Frankel Timothy , Vatan Linda , Szeliga Wojciech , Dou Yali , Owens Scott , Marquez Victor , Tao Kaixiong , Huang Emina , Wang Guobin , Zou Weiping
Published: March 2023

This is Supplementary Tables I and II Table 1: RT-PCR primers and ChIP primers Table 2: shRNA Sequences
Figure S2 from PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer
Authors: Nagarsheth Nisha , Peng Dongjun , Kryczek Ilona , Wu Ke , Li Wei , Zhao Ende , Zhao Lili , Wei Shuang , Frankel Timothy , Vatan Linda , Szeliga Wojciech , Dou Yali , Owens Scott , Marquez Victor , Tao Kaixiong , Huang Emina , Wang Guobin , Zou Weiping
Published: March 2023

Figure S2: Effects of H3K27me3 on Th1-type chemokine production in colon cancer cells
Supplementary Figure 4 from SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness
Authors: Crottès David , Rapetti-Mauss Raphael , Alcaraz-Perez Francisca , Tichet Mélanie , Gariano Giuseppina , Martial Sonia , Guizouarn Hélène , Pellissier Bernard , Loubat Agnès , Popa Alexandra , Paquet Agnès , Presta Marco , Tartare-Deckert Sophie , Cayuela Maria Luisa , Martin Patrick , Borgese Franck , Soriani Olivier
Published: March 2023

Sig1R silencing inhibits CRC HCT-116 cell motility
Supplementary Figure 6 from A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis
Authors: Fang Liang , Zhu Qionghua , Neuenschwander Martin , Specker Edgar , Wulf-Goldenberg Annika , Weis William I. , von Kries Jens P. , Birchmeier Walter
Published: March 2023

Fig. S6 Influence of LF3 on gene profiling and differentiation of mouse salivary gland CSCs.
Supplementary Figure 1 from SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness
Authors: Crottès David , Rapetti-Mauss Raphael , Alcaraz-Perez Francisca , Tichet Mélanie , Gariano Giuseppina , Martial Sonia , Guizouarn Hélène , Pellissier Bernard , Loubat Agnès , Popa Alexandra , Paquet Agnès , Presta Marco , Tartare-Deckert Sophie , Cayuela Maria Luisa , Martin Patrick , Borgese Franck , Soriani Olivier
Published: March 2023

FDM induces a stable increase in hERG current in a Sig1R-dependent manner but does not alter channel maturation
Supplementary Figure 3 from A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis
Authors: Fang Liang , Zhu Qionghua , Neuenschwander Martin , Specker Edgar , Wulf-Goldenberg Annika , Weis William I. , von Kries Jens P. , Birchmeier Walter
Published: March 2023

Fig. S3 Inhibition of Wnt signaling by LF3 in colon cancer cells.
Supplementary Table S4 from Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance
Authors: Busch Susann , Sims Andrew H. , Stål Olle , Fernö Mårten , Landberg Göran
Published: March 2023

Gene list of customized RT² Profiler PCR Array (SABiosciences).
Supplementary Table S2 from Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance
Authors: Busch Susann , Sims Andrew H. , Stål Olle , Fernö Mårten , Landberg Göran
Published: March 2023

Correlations of SMAD2 phosphorylation to clinico-pathological parameters and molecular markers.
Supplemental Figures from SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth
Authors: Park Seong-Hoon , Ozden Ozkan , Liu Guoxiang , Song Ha Yong , Zhu Yueming , Yan Yufan , Zou Xianghui , Kang Hong-Jun , Jiang Haiyan , Principe Daniel R. , Cha Yong-Il , Roh Meejeon , Vassilopoulos Athanassios , Gius David
Published: March 2023

Supplemental Figure S1. PKM2 is acetylated by PCAF and Tip60. Supplemental Figure S2. SIRT2-knockdown stable MCF7, MDA-MB-231, and HeLa cell lines showed decreased PK activity and increased glycolysis rate. Supplemental Figure S3. LC-Ms/Ms analysis to detect potentially reversible acetylation sites of PKM2 peptide. Supplemental Figure S4. Sirt2-/--MMT cell growth was inhibited by SIRT2 and PKM2-deacetylation mimic mutants. Supplemental Figure S5. PKM2 deacetylation mimic mutants (K62R and K305R) increased PKM2 tetramer formation.
Supplementary Figure S7 from Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance
Authors: Busch Susann , Sims Andrew H. , Stål Olle , Fernö Mårten , Landberg Göran
Published: March 2023

Transcriptional activity and TGFBR2 overexpression in MCF7 and tamoxifen-resistant cells (TAM-R).
Supplemental Figures Legends from SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth
Authors: Park Seong-Hoon , Ozden Ozkan , Liu Guoxiang , Song Ha Yong , Zhu Yueming , Yan Yufan , Zou Xianghui , Kang Hong-Jun , Jiang Haiyan , Principe Daniel R. , Cha Yong-Il , Roh Meejeon , Vassilopoulos Athanassios , Gius David
Published: March 2023

Supplemental figure legends for supplemental figures S1-S5.
Supplementary Figure S3 from SSBP1 Suppresses TGFβ-Driven Epithelial-to-Mesenchymal Transition and Metastasis in Triple-Negative Breast Cancer by Regulating Mitochondrial Retrograde Signaling
Authors: Jiang Hong-Lin , Sun He-Fen , Gao Shui-Ping , Li Liang-Dong , Huang Sheng , Hu Xin , Liu Sheng , Wu Jiong , Shao Zhi-Ming , Jin Wei
Published: March 2023

(A) The relative mtDNA content was analyzed by real-time PCR amplification of mtDNA encoded COX I and nuclear encoded GAPDH. (B) Statistical data of mitochondrial ROS generation in the indicated cells. (C) Western blot analysis of p-SMAD3 and SMAD3 expression in the indicated cells. (D) The migration abilities of indicated cell line were evaluated by Transwell assays in vitro. *** P < 0.005 compared with control. (E) Left: Control and CCCP-treated (20 μM for 2 h) MDA-MB-231 and MDA-MB-231shSSBP1 cells were incubated with or without added FK506 (10 nM). Total cellular protein fractions were subjected to western blot analysis using indicated antibodies. Right: Total cellular protein fractions of MDA-MB-231 cells transfected with CnA and treated with or without FK506 analyzed by western blot analysis using indicated antibodies. (F) Control and CCCP-treated (20 μM for 2 h) MDA-MB-231 and MDA-MB-231shSSBP1 cells were incubated with or without added FK506 (10 nM). Nuclear protein fractions were subjected to western blot analysis using indicated antibodies. (G) Western blot analysis of E-cadherin and Fibronectin expression in the indicated cells.
Supplementary Figure S3 from Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance
Authors: Busch Susann , Sims Andrew H. , Stål Olle , Fernö Mårten , Landberg Göran
Published: March 2023

Viability of MCF7 with TGFBR2-specific knockdown.
Supplementary Figure S2 from SSBP1 Suppresses TGFβ-Driven Epithelial-to-Mesenchymal Transition and Metastasis in Triple-Negative Breast Cancer by Regulating Mitochondrial Retrograde Signaling
Authors: Jiang Hong-Lin , Sun He-Fen , Gao Shui-Ping , Li Liang-Dong , Huang Sheng , Hu Xin , Liu Sheng , Wu Jiong , Shao Zhi-Ming , Jin Wei
Published: March 2023

(A) Kaplan-Meier curves showing that patients with stomach adenocarcinoma and an SSBP1 gene alteration have shorter lifespans than those with stomach adenocarcinoma without an SSBP1 gene alteration in the TCGA cohort (P = 0.013; log-rank test). (B) The left panel shows representative images of mouse lungs six weeks after tail vein injection with the indicated cells, and the right panel shows number of mouse lung metastases (*, P < 0.05). (C) Real-time PCR analysis of metastasis-related target genes by TGF-β in control and stable SSBP1-depleted MDA-MB-231 and MDA-MB-468 cells. The data are presented as the mean {plus minus} SD.
supplemental materials and methods from Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone–Related Protein
Authors: Kim Wonnam , Takyar Farzin M. , Swan Karena , Jeong Jaekwang , VanHouten Joshua , Sullivan Catherine , Dann Pamela , Yu Herbert , Fiaschi-Taesch Nathalie , Chang Wenhan , Wysolmerski John
Published: March 2023

supplemental materials and methods
supplemental figures from Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone–Related Protein
Authors: Kim Wonnam , Takyar Farzin M. , Swan Karena , Jeong Jaekwang , VanHouten Joshua , Sullivan Catherine , Dann Pamela , Yu Herbert , Fiaschi-Taesch Nathalie , Chang Wenhan , Wysolmerski John
Published: March 2023

Supplemental Figure 1. A&B) Whole mount preparations of mammary glands from 9-week-old virgin CaSR; Supplemental Figure 2. A) Representative immunoblot showing total cdk2 levels in BT474 cells {plus minus} NPS2143 or control, CaSRKD, and PTHrPKD BT474 cells at different calcium concentrations; Supplemental Figure 3. A) Representative TUNEL staining in control MDA-MB-231.1833 cells {plus minus} NPS2143, and CaSRKD and PTHrPKD MDA-MB-231.1833 cells at different calcium concentrations; Supplemental Figure 4. A) Representative immunoblot for AIF in cytoplasmic or nuclear extracts from cells cultured from control MMTV-PyMT tumors {plus minus} NPS2143 and exposed to 5mM extracellular calcium; Supplemental Figure 5. BrdU incorporation in CaSRKD (A) or PTHrPKD (B) MDA-MB-231.1833 cells {plus minus} 10nM or 100nM PTHrP.
Supplementary Table S4 from Hemolytic E. coli Promotes Colonic Tumorigenesis in Females
Authors: Jin Ye , Tang Senwei , Li Weilin , Ng Siew Chien , Chan Michael W.Y. , Sung Joseph J.Y. , Yu Jun
Published: March 2023

Primers used in this study
Supplementary Table S3 from Hemolytic E. coli Promotes Colonic Tumorigenesis in Females
Authors: Jin Ye , Tang Senwei , Li Weilin , Ng Siew Chien , Chan Michael W.Y. , Sung Joseph J.Y. , Yu Jun
Published: March 2023

Cancer-associated gene fold regulation by E. coli strains in the NCM460 cell line, identified using the Human Cancer PathwayFinder (TM) RT2 Profiler (TM) PCR Array
Supplementary Figures 1 though 6 from Balancing Protein Stability and Activity in Cancer: A New Approach for Identifying Driver Mutations Affecting CBL Ubiquitin Ligase Activation
Authors: Li Minghui , Kales Stephen C. , Ma Ke , Shoemaker Benjamin A. , Crespo-Barreto Juan , Cangelosi Andrew L. , Lipkowitz Stanley , Panchenko Anna R.
Published: March 2023

Fig. S1. The distribution of unfolding and binding free energy changes for Single, Recurrent and Random class mutations for all states in CBL activation cycle. Fig.S2. The distribution of local RMSD of mutant structures for Single, Recurrent and Random class mutations for CBL-E2-S and pCBL-E2-S states. Fig. S3. Mean values and standard errors of local RMSD of mutant structures for different classes of mutations for CBL-E2-S and pCBL-E2-S states, respectively. Fig. S4. The number of "Single" and "Recurrent" mutations located on CBL-E2 interface, non-interface and interior regions in inactive CBL-E2-S and active pCBL-E2-S structures. Fig. S5. Structures of wild type and K382E mutant for all states. Fig. S6. EGFR ubiquitination by Cbl mutants that retain wild-type activity in A549 and Hela cells.
Supplementary Tables and Legends from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models
Authors: Weir Hazel M. , Bradbury Robert H. , Lawson Mandy , Rabow Alfred A. , Buttar David , Callis Rowena J. , Curwen Jon O. , de Almeida Camila , Ballard Peter , Hulse Michael , Donald Craig S. , Feron Lyman J.L. , Karoutchi Galith , MacFaul Philip , Moss Thomas , Norman Richard A. , Pearson Stuart E. , Tonge Michael , Davies Gareth , Walker Graeme E. , Wilson Zena , Rowlinson Rachel , Powell Steve , Sadler Claire , Richmond Graham , Ladd Brendon , Pazolli Ermira , Mazzola Anne Marie , D'Cruz Celina , De Savi Chris
Published: March 2023

Supplementary Table 1 contains crystallographic data collection and refinements statistics for AZD9496 binding to the human estrogen receptor α ligand binding domain, Supplementary Table 2 shows the rate constants for association, dissociation and equilibrium dissociation constant for AZD9496 binding to the human estrogen receptor α ligand binding domain, Supplementary Table 3 displays IC50 values for AZD9496 binding to androgen, glucocorticoid, progesterone and estrogen receptor β ligand binding domains, Supplementary Table 4 displays IC50s values for cell growth inhibition of a panel of estrogen receptor positive and negative cell lines using AZD9496.
Supplementary Figures from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models
Authors: Weir Hazel M. , Bradbury Robert H. , Lawson Mandy , Rabow Alfred A. , Buttar David , Callis Rowena J. , Curwen Jon O. , de Almeida Camila , Ballard Peter , Hulse Michael , Donald Craig S. , Feron Lyman J.L. , Karoutchi Galith , MacFaul Philip , Moss Thomas , Norman Richard A. , Pearson Stuart E. , Tonge Michael , Davies Gareth , Walker Graeme E. , Wilson Zena , Rowlinson Rachel , Powell Steve , Sadler Claire , Richmond Graham , Ladd Brendon , Pazolli Ermira , Mazzola Anne Marie , D'Cruz Celina , De Savi Chris
Published: March 2023

Supplementary Figure 1 contains a Western blot showing the amount of estrogen receptor remaining after treatment of MCF-7 cells with AZD9496, fulvestrant and estradiol alongside GAPDH protein levels as an internal gel loading control; Supplementary Figure 2 shows the rate of decreased detection by mass spectrometry of an estrogen receptor heavy isotype labelled peptide over time after treatment of cells with AZD9496, fulvestrant and tamoxifen and the calculated half life; Supplementary Figure 3 shows the degradation of estrogen receptor α by AZD9496, fulvestrant and estradiol in the presence of +/- 10 μM proteosomal inhibitor MG132; Supplementary Figure 4 contains a Western blot showing the re-emergence over 48 hours of estrogen receptor α following removal of AZD9496, fulvestrant and estradiol compounds from MCF-7 cells; Supplementary Figure 5 shows a bar chart of the measured estradiol levels in the blood of mice over 42 days after implantation of the mice with estrogen pellets to support growth of the MCF-7 cells as a tumour in mice; Supplementary Figure 6 shows the effects of AZD9496, fulvestrant and tamoxifen on mRNA levels of estrogen receptor regulated genes in vitro and in vivo; Supplementary Figure 7 shows the levels of estrogen receptor α protein remaining in tumours from the HCC1428 LTED model after treatment with AZD9496 and fulvestrant.
CAN-15-1348R-Supplementary Figure-S4 from Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression
Authors: Mittapalli Venugopal R. , Madl Josef , Löffek Stefanie , Kiritsi Dimitra , Kern Johannes S. , Römer Winfried , Nyström Alexander , Bruckner-Tuderman Leena
Published: March 2023

Immunofluorescence stainings
Supplementary Table and Figure Legends from Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis
Authors: Guo Yabin , Updegraff Barrett L. , Park Sunho , Durakoglugil Deniz , Cruz Victoria H. , Maddux Sarah , Hwang Tae Hyun , O'Donnell Kathryn A.
Published: March 2023

Legends for Supplementary Tables S1-S4 and Supplementary Figures S1-S13.
CAN-15-1348R-Supplementary Figure-S2 from Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression
Authors: Mittapalli Venugopal R. , Madl Josef , Löffek Stefanie , Kiritsi Dimitra , Kern Johannes S. , Römer Winfried , Nyström Alexander , Bruckner-Tuderman Leena
Published: March 2023

Immunofluorescence stainings of mouse lung
Supplementary Figure S11 from Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis
Authors: Guo Yabin , Updegraff Barrett L. , Park Sunho , Durakoglugil Deniz , Cruz Victoria H. , Maddux Sarah , Hwang Tae Hyun , O'Donnell Kathryn A.
Published: March 2023

Validation of CIS genes in vivo.
Supplementary Tables S1-S3 from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Authors: Boutet Marie , Gauthier Ludiane , Leclerc Marine , Gros Gwendoline , de Montpreville Vincent , Théret Nathalie , Donnadieu Emmanuel , Mami-Chouaib Fathia
Published: March 2023

Statistical analyses of results shown in Figure 1A (S1); Statistical analyses of results shown in Supplementary Figure 1A (S2); Statistical analyses of results shown in Supplementary Figure 2B (S3).
CTL CD103+ treated TGF-β on rICAM-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Authors: Boutet Marie , Gauthier Ludiane , Leclerc Marine , Gros Gwendoline , de Montpreville Vincent , Théret Nathalie , Donnadieu Emmanuel , Mami-Chouaib Fathia
Published: March 2023

CTL CD103+ treated TGF-β on rICAM-Fc from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Supplementary Tables S1-S4 from Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis
Authors: Xing Cheng , Lu Xing-Xing , Guo Peng-Da , Shen Tong , Zhang Shen , He Xiao-Shun , Gan Wen-Juan , Li Xiu-Ming , Wang Jing-Ru , Zhao Yuan-Yuan , Wu Hua , Li Jian-Ming
Published: March 2023

Correlation of USP4 expression with patients' clinicopathological variables in 167 cases of CRC (S1); Human USP4 shRNA target sequences (S2); Human USP4 and PRL-3 siRNA target sequences (S3); Primers for qPCR (S4).
Supplementary Figure 1 from Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling
Authors: Peng Dongjun , Tanikawa Takashi , Li Wei , Zhao Lili , Vatan Linda , Szeliga Wojciech , Wan Shanshan , Wei Shuang , Wang Yin , Liu Yan , Staroslawska Elzbieta , Szubstarski Franciszek , Rolinski Jacek , Grywalska Ewelina , Stanisławek Andrzej , Polkowski Wojciech , Kurylcio Andrzej , Kleer Celina , Chang Alfred E. , Wicha Max , Sabel Michael , Zou Weiping , Kryczek Ilona
Published: March 2023

MDSC phenotype and suppressor activity
Supplemental Figure 5 from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments
Authors: Morris Zachary S. , Guy Emily I. , Francis David M. , Gressett Monica M. , Werner Lauryn R. , Carmichael Lakeesha L. , Yang Richard K. , Armstrong Eric A. , Huang Shyhmin , Navid Fariba , Gillies Stephen D. , Korman Alan , Hank Jacquelyn A. , Rakhmilevich Alexander L. , Harari Paul M. , Sondel Paul M.
Published: March 2023

Immunohistochemistry demonstrates impact of radiation and immunocytokine injection on tumor infiltration by NK and CD8 and CD4-positive T cells.
Supplementary Materials and Methods from Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer
Authors: Wang Yuxuan , Liu Changzheng , Luo Min , Zhang Zhengyi , Gong Jianan , Li Jingjing , You Lei , Dong Lei , Su Rui , Lin Haishuang , Ma Yanni , Wang Fang , Wang Yi , Chen Jie , Zhang Junwu , Jia Hongyan , Kong Yan , Yu Jia
Published: March 2023

Supplementary Materials and Methods. Description of additional methods and procedures used in the study.
Supplementary Figure S8 from Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer
Authors: Wang Yuxuan , Liu Changzheng , Luo Min , Zhang Zhengyi , Gong Jianan , Li Jingjing , You Lei , Dong Lei , Su Rui , Lin Haishuang , Ma Yanni , Wang Fang , Wang Yi , Chen Jie , Zhang Junwu , Jia Hongyan , Kong Yan , Yu Jia
Published: March 2023

Supplementary Figure S8. Correlation between mIR-29s expression and catenin-ÃŽ' in 66 cases of GCs.
Supplementary Figure S7 from Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer
Authors: Wang Yuxuan , Liu Changzheng , Luo Min , Zhang Zhengyi , Gong Jianan , Li Jingjing , You Lei , Dong Lei , Su Rui , Lin Haishuang , Ma Yanni , Wang Fang , Wang Yi , Chen Jie , Zhang Junwu , Jia Hongyan , Kong Yan , Yu Jia
Published: March 2023

Supplementary Figure S7. Catenin-ÃŽ' protein levels depict an increase in the GC tissues.
Supplemental Figures from Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth
Authors: Pathania Rajneesh , Ramachandran Sabarish , Mariappan Gurusamy , Thakur Priyanka , Shi Huidong , Choi Jeong-Hyeon , Manicassamy Santhakumar , Kolhe Ravindra , Prasad Puttur D. , Sharma Suash , Lokeshwar Bal L. , Ganapathy Vadivel , Thangaraju Muthusamy
Published: March 2023

The Supplemental figure file contains severn additional figures. Supplementary figure 1 shows that the Lin-CD49f+CD24+ cells are tumorigenic, Supplementary Figure 2 provide additional evidence for myoepithelial stem and luminal progenitor cells are the targets of genetic mutations/epigenetic modifications that lead to tumor cell of origin, Supplementary Figure 3, shows that the treatment with DNMT and HDAC inhibitors reduces colony formation, Supplementary Figure 4l provide a Flow chart for RNA sequencing analysis, Supplementary Figure 5 shows a heat map for differential expression of genes in normal and in breast cancer, Supplementary Figure 6 shows RAD51AP1 expression in basal breast cancer, and Supplementary Figure 7 shows SPC25 expression in basal breast cancer
Supplementary Figure S10 from Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer
Authors: Wang Yuxuan , Liu Changzheng , Luo Min , Zhang Zhengyi , Gong Jianan , Li Jingjing , You Lei , Dong Lei , Su Rui , Lin Haishuang , Ma Yanni , Wang Fang , Wang Yi , Chen Jie , Zhang Junwu , Jia Hongyan , Kong Yan , Yu Jia
Published: March 2023

Supplementary Figure S10. mIR-29c and catenin-ÃŽ' expression is determined in GC cells treated with imatinib.