bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Docking Studies on Gingerol Analogues toward Mushroom Tyrosinase
Authors: Sabrina Benouis Sabrina Benouis , Fouad Ferkous Fouad Ferkous , Khairedine Kraim Khairedine Kraim , Ahmed Allali Ahmed Allali , Youcef Saihi Youcef Saihi
Published: November 2021

The gingerol presents the starting point of our work which aims to discover new inhibitors of the tyrosinase enzyme. Therefore, we have studied the activity of gingerol derivatives as inhibitors against mushroom tyrosinase based on the molecular docking.
Molecular docking studies were performed on a series of gingerol analogues retrieved from Zinc database (with 70% as similarity threshold). The gingerol analogues were docked within the active site region of mushroom tyrosinase (PDB: 2Y9X) using Molegro Virtual Docker V.5.0.
The results of molecular docking studies revealed that some analogues of gingerol have higher Moldock score (in terms of negative energy) than gingerol and the experimentally known inhibitors of tyrosinase, and showed favourable molecular interactions exhibiting common molecular interaction with Ala323, Met280 and Asn260 residues of tyrosinase. Furthermore, the top docked compounds used in this work do not violate the Lipinsky rule of five.
Potassium-Promoted Three-Dimensional Mesoporous Pt/MnO2 for Formaldehyde Elimination at Zero Degree
Authors: Shengnan Guan Shengnan Guan , Wenzhi Li Wenzhi Li , Jianru Ma Jianru Ma , Qingchuan Liu Qingchuan Liu , Kun Chen and Qi Zhang Kun Chen and Qi Zhang
Published: November 2021

In this work, three-dimensional mesoporous MnO2, K/MnO2, Pt/MnO2 and K-Pt/MnO2 catalysts were prepared through hard-template method. The additional K/Pt had significantly improved the HCHO oxidation activity. The K-Pt/MnO2 catalyzed complete HCHO oxidation was achieved at 0℃ with space velocity (GHSV) at 50000 ml/(gand#183;h). With the excellent catalytic performance, K-Pt/MnO2 exhibited a higher ratio of Oads(surface adsorbed oxygen)/Olatt(surface lattice oxygen) and Mn3+/Mn4+ ions than the other catalysts. Meanwhile, it was still stable after running a 70h reaction. Overall, the K-Pt/MnO2 was a promising material for HCHO elimination.
Evaluation of Trans Fat in Vermicelli by Fourier Transform Infrared Spectroscopy in Combination with Chemometric Technique
Authors: Sarfaraz Ahmed Mahesar Sarfaraz Ahmed Mahesar , Taimoor Hassan Shaikh Taimoor Hassan Shaikh , Zahid Hussain Shar Ghulam Abbas Kandhro Zahid Hussain Shar Ghulam Abbas Kandhro , Abdul Rauf Khaskheli and Syed Tufail Hussain Sherazi Abdul Rauf Khaskheli and Syed Tufail Hussain Sherazi
Published: November 2021

Since there is limited knowledge about trans fat levels in snack foods available in Pakistan. This study aimed to determine trans fat content in fried vermicelli (a common snack food). It is prepared in partially hydrogenated oil (ghee), which is the main cause of trans fat formation. Twenty-one fried vermicelli samples were collected from different local shops of Hyderabad, Pakistan and subjected to oil extraction by using Soxhlet method. Partial least square regression model was developed to quantify trans fats in fried vermicelli using FTIR spectroscopy. Total oil content in fried vermicelli ranged between 17.28- 32.99%. FTIR results revealed that fried vermicelli showed trans fats in between 7.3-20.9% in extracted oil, whereas total trans fat in food was ranged at 1.3-5.9%. The FTIR data of trans fat was compared with GC-MS data and found comparable results (pandgt;0.05). Presence of high trans fat in fried vermicelli is an alarming issue for the health of consumers.
Modeling and Prediction of Gas Chromatography Relative Retention Times of Volatile Organic Compounds
Authors: Mounia Zine Mounia Zine , Amel Bouakkadia Amel Bouakkadia , Leila Lourici and Djelloul Messadi Leila Lourici and Djelloul Messadi
Published: November 2021

The theme of this paper is to foresee relative retention time of 122 volatile organic compounds. QSRR analysis was accomplished on a serial of 122 VOCs. Multiple Linear Regression (MLR) and support vector machine (SVM) methods were used to build linear and nonlinear (QSRR) models, respectively, which correlate the (RTT) values of these chemical substance to their structural descriptors. At first, the data set was separated using Kennard and Stone algorithm into a training set (92 chemicals) and a test set (30 chemicals) for statistical external validation. The five-dimensional models were developed using as independent variables the theoretical descriptors derived from the DRAGON software during the application of the procedure GA (genetic algorithm) - VSS (Variable Subset Selection). The robustness and the predictive performance of the MLR model have been demonstrated by inside and outer statistical validation.
Non-linear technique leads to the best QSRR model with good internal and external predictive abilities. It is based on support vector machines using the RBF function for the optimal parameters values. The values of and were 17, 0.2, 0.2, respectively.
Application of Modified PANI-ZnO Composites for NH3Gas Sensor at Ambient Temperature
Authors: Naimat Ullah Naimat Ullah , Anwar Ul Haq Ali Shah Anwar Ul Haq Ali Shah , Fazal Akbar Jan Fazal Akbar Jan , Rotaba Ansir Rotaba Ansir , Wali Muhammad Wali Muhammad
Published: November 2021

Polyaniline and zinc oxide nanoparticles were successfully synthesized through inverse emulsion polymerization method and hydrothermal method respectively. For ammonia gas sensing using LCR meter thin film of the composite was fabricated by using spin coater. The functional groups, morphological, optical, structural properties of zinc oxide nanoparticles, polyaniline (emeraldine salt) and composites were investigated by FTIR spectroscopy, Scanning electron microscopy (SEM), UV- Visible spectroscopy and XRD analysis. The formation of ZnO particles of different shapes in the nano range was confirmed from UV-visible and XRD analysis. UV visible spectrum shows the formation of nanoparticles of ZnO. Thin film of Polyaniline/zinc oxide composites were deposited on the surface of copper interdigitated electrode. The fabricated device showed sensitivity to ammonia gas (NH3) at ambient temperature (300 K). It was observed that the resistance is decreases with the increase of volume of ammonia gas. The electrical properties were also investigated of the different concentration of nanocomposite. Optimum sensing response was achieved with PANI in the presence of 50 wt% ZnO nanoparticles. It may also be inferred from this study that the solution mixing process to produce composites has promising future if handled carefully.
Sorption of Uranium (VI) Ions by a Sorbent Based on a Copolymer of Maleic Anhydride with Styrene Modified by N, Nand#39;-diphenylguanidine
Authors: Fidan Bahmanova Fidan Bahmanova , Sevinj Hajiyeva Sevinj Hajiyeva , Elnara Alirzaeva Elnara Alirzaeva , Nazim Shamilov and Famil Chyragov Nazim Shamilov and Famil Chyragov
Published: November 2021

In this paper the results of a study on the extraction and concentration of micro-quantities of uranium (VI) with a polymeric chelating sorbent with fragments of N, N and#39;diphenylguanidine is discussed. There was studied a static sorption capacity on K+ ions ((SSC = 9.3 mmol / g) and there were determined the ionization constants of ionogenic groups ( =3.97; =8.47) by potentiometric titration. The optimal conditions of the sorption of elements (pHopt, sorption time - τ, the influence of ionic strength - μ) were determined by the dependence of the sorption capacity (SC, mg/g) on the parameter being studied; the sorption capacity of the sorbent (SC) was determined from the saturation curve constructed under optimal sorption conditions. The maximum degree of extraction of uranium by sorbents is achieved from solutions with pH 5. Sorption equilibrium is achieved within 2 hours of contact of the solution with the sorbent. With an increase in the concentration of the uranyl ion in the solution, the amount of the sorbed metal increases, and at a concentration of 8•10–3 mol/l, it becomes maximal (pH = 5, = 8•10–3 mol/l, Vgen = 20 ml, msorb. = 0.05 g, SC = 1258 mg/g). Limits of detection (3, n=20) are 13.9 ng/ml. The effect of various mineral acids(HClО4, H2SО4, HNО3, HCl) with the same concentrations on the desorption of uranium (VI) from the sorbent was studied. The developed technique was applied to determine uranium in oil sludge.
Optimization of Ultrasound-Assisted Extraction of Polyphenols from Xanthoceras sorbifolia Husks and their Determination using HPLC
Authors: Xue Mei Xue Mei , Guoqian Li Guoqian Li , Yong Lin Yong Lin , Bin Yuan Bin Yuan , Ying Wei Ying Wei , Chunyan Yang and Chunyang Zhou Chunyan Yang and Chunyang Zhou
Published: November 2021

X. sorbifolia can be used as both food material and medicinal plant. In this study, ultrasound-assisted extraction (UAE) was firstly used to optimize the extraction process of total polyphenols from X. sorbifolia husks. Ultrasonic time, ultrasonic temperature, ratio of solvent to material and volume fraction of ethanol were investigated and optimized by orthogonal experiments. Then, High Performance Liquid Chromatography (HPLC) was applied to analyze the polyphenols of the extract under the optimal extraction process. The optimized results for UAE was 40 min of ultrasonic time, 40 ℃ of ultrasonic temperature, 100:1 mL/g of solvent to material ratio and 60% aqueous ethanol. Under the optimal extraction process, the total polyphenol content (TPC) of the extract was 23.16 mg GAE/g DW. Furthermore, the most abundant polyphenols in X. sorbifolia husks extract, such as gallic acid, protocatechuic acid, epicatechin, myricetin-3-O-β-D-rutinoside, rutin and quercetin, were analysed using HPLC. In addition, UAE extract showed antioxidant activity in a concentration-dependent manner. Accordingly, X. sorbifolia husks can be used as a rich source of natural antioxidants. To sum up, these results provided a solid chemical basis underlying the future research and application of Xanthoceras sorbifolia husks.
Synthesis and Biological Evaluation of Novel 4-Phenylaminobenzofuro[2,3-d]pyrimidine Derivatives
Authors: Ju liu Ju liu , Jun Li Jun Li , Jian tao Shi Jian tao Shi , Jie Li Jie Li , Xue chen Hao Xue chen Hao , Duang zheng Song Duang zheng Song , Yang Wang Yang Wang , Shi Ding and Ye Chen Shi Ding and Ye Chen
Published: November 2021

A series of novel 4-phenylaminobenzofuro[2,3-d]pyrimidine derivatives had been prepared and assessed for their in vitro antiproliferative activities against three lung cancer cell lines (A549, H460 and H1975). The bioassay results showed most of the designed compounds exhibited potential antiproliferation activities. Among them, compound 8f exhibited remarkable inhibitory activity against A549 and H460 cell lines with IC50 value of 2.54 μM and 2.68 μM, respectively, which was comparable to that of the positive control sorafenib (IC50 = 2.69 μM for A549 and 3.71 μM for H460). AO/EB staining suggests that compound 8f could induce apoptosis in A549 cells. Furthermore, cell cycle analyses show that compound 8f increased G0/G1 A549 cells arrest in a concentration-dependent manner. The preliminary structure-activity relationships (SARs) studies indicated that mono-electron-withdrawing groups (mono-EWGs) on the phenyl ring are positive on the antitumor activity.
Neuroprotectıve Potential of the Tubers of Corydalis triternata Zucc. Growing in Turkey
Authors: Mehtap K l c Mehtap K l c , Erdal Kaya Erdal Kaya , Ayhan Ibrahim Aysal Ayhan Ibrahim Aysal , Bilge Sener Bilge Sener
Published: November 2021

The continuing research for the determination of bioactive secondary metabolites from Turkish geophytes as therapeutic agents for dementia is mainly based on the need for drug candidates affected to brain areas. In this study, the in vitro anticholinesterase activity of the alkaloidal fractions of the tubers of Corydalis triternata Zucc. was investigated for their neuroprotective potential. Furthermore, the content of the active alkaloid fractions of the tubers was determined by LC-Q-TOF-MS. The tubers of Corydalis triternata Zucc. were collected from Hatay province of Turkey. The plant species were also preserved as ex-situ in Yalova-Turkey. The alkaloidal extract was prepared from the tubers. The anticholinesterase activities of the extracts and fractions were tested by modification of the Ellman’s method. The optimization of LC-MS conditions was used in ESI in the positive ion mode. The in vitro tests were highlighted that the alkaloidal extract of the tubers exhibited the highest activity against AChE and BuChE with IC50 values of 17.56 and#177; 1.0 g/mL and 326.23 and#177; 2.6 g /mL (galanthamine 6.8 and#177; 0.5 g /mL and 344.4 and#177; 8.2 g /mL as positive control), respectively. The fractions CK-3 and 4 were showed the highest inhibitory activity against AChE with the IC50 value (6.88 and#177; 0.3 g mL and 7.26 and#177; 0.3 g /mL), the fractions CK-5,6,7 and 8 have indicated potent inhibitory activities by compared with galanthamine, which was used as positive control with IC50 value 6.8 and#177; 0.5 g /mL. Among the fractions obtained from the alkaloidal extract, protoberberine-type alkaloids were exerted the most promising activity against both cholinesterases. The present study was described for the first time the in vitro anticholinesterase activity of Corydalis triternata Zucc. as neuroprotective potential and their metabolite profile by LC-Q-TOF-MS. Besides, the anticholinesterase assays on alkaloidal extract and its fractions showed that protoberberine-type alkaloids were determined the most potent inhibitor against AChE and BuChE.
Synthesis, Crystal Structure and Antitumor Activity of 3-(2,4-dichlorophenyl)-2-phenyl-5-(p-tolyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
Authors: Jin Liu Jin Liu , Juan Zhao Juan Zhao , Jiu fu Lu Jiu fu Lu
Published: November 2021

The title compound, 3-(2,4-dichlorophenyl)-2-phenyl-5-(p-tolyl)- 7-(trifluoromethyl)pyrazolo[1,5-a] pyrimidine (C26H16Cl2F3N3, Mr = 498.32) has been synthesized by condensation of 4,4,4-trifluoro-1-(p-tolyl)butane- 1,3-dione with 4-(2,4-dichlorophenyl)-3-phenyl-1H-pyrazol-5-amine. The latter was prepared from 2,4-dichlorophenylaceton itrile and ethyl benzoate through Claisen condensation and then cyclization with hydrazine hydrate. The crystal structure of the title compound was determined. In addition, the title compound possesses marked inhibition against the proliferation of human lung adenocarcinoma cell line A549 and human gastric cancer cell line MKN45, displaying promising anticancer activities.
Synthesis and Characterization of CuMnOx-Bentonite as Efficient Catalyst for Oxidation of m-xylene
Authors: Mo Thi Nguyen Mo Thi Nguyen , Cam Minh Le Cam Minh Le , Tuan Minh Nguyen Tuan Minh Nguyen , Hao Hoang Nguyen Hao Hoang Nguyen , Anwar ul Haq Ali Shah Hung Van Hoang Anwar ul Haq Ali Shah Hung Van Hoang
Published: November 2021

Catalytic oxidation of organic volatile compounds (VOCs) is considered superior to conventional methods because very low concentration of VOCs can also be oxidized and removed at low temperatures without consumption of addditional fuel and introduction of NOx compounds into the environment. Herein, the synthesis of MnO2 nanoparticles on bentonite (Bent) support in the presence of CuO for catalytic oxidation of m-xylene is reported. The synthesized materials were analyzed with FT-IR, XRD, and TEM analysis for structural and morphological characterization. XRD and TEM analysis indicated the formation of δ-MnO2 with sheet structure on Bent surface. Temperature-programmed reduction (H2-TPR) of hydrogen was used to investigate catalytic performance of δ-MnO2 towards oxidation of m-xylene at different temperatures. The catalytic activity was strongly dependent on the δ-MnO2 content in the synthesized material. 100 % oxidation of m-xylene with observed with 10% Mn content at temperature below than 325 oC. Intersetingly introduction of CuO greatly improved the catalytic activity of Mn-Bent materials. The presence of Cu in Mn-Bent has greatly reduced the temperature for complete oxidation of m-xylene. In this case100% conversion of m-xylene was observed at 250 oC.
Synthesis and Applications of Antimicrobial and UV Protected Polymeric glass coatings
Authors: Phool Shahzadi and Syeda Rubina Gilani Phool Shahzadi and Syeda Rubina Gilani
Published: November 2021

polymeric materials along with nanoparticles are widely used to protect from microbial propagation. In humid environments, enclosed edifice is amongst the foremost propagation substrates aimed at microorganisms. Antimicrobial coatings could help to stop microbial proliferation or, reduce the number of microorganisms growing on inside buildings. This paper deals with inhibition of Escherichia coli bacteria by TiO2 and silver nano-particles doping along with poly acrylate-based copolymers. Coated glass was characterized for FTIR, antimicrobial activity, UV Visible Spectroscopy and water contact angle for hydrophobicity and SEM analysis for surface morphology. The disk diffusion method was used for bacterial inhibition. Results revealed that developed material has good adhesion with glass and shows transparency, hydrophobicity and antibacterial activity. Which shows that coating material can be used for significant antibacterial coatings to protect window glass table ware glass doors etc. further these coatings are transparent, UV radiation protected and hydrophobic in nature which also enhance the self-cleaning effects. In addition, the coating has photocatalytic activity due to the presence of TiO2 and showed momentous antibacterial events after 2,4 and 6 hrs and this efficiency would be increased by improving formulation composition.
Biodegradation of Novacron Turqueiose (Reactive Blue 21) by Pseudomonas aeruginosa
Authors: Muhammad Ikram Muhammad Ikram , Muhammad Zahoor Muhammad Zahoor , Ezzat Khan and Sahibzada Muhammad Umar Khayam Ezzat Khan and Sahibzada Muhammad Umar Khayam
Published: November 2021

In the present study four bacterial strains Escherichia Coli, Salmonella typhi, Shiegella and Pseudomonas aeruginosa were used to evaluate their dye decolorization/degradation ability. Out of these bacterial strains Pseudomonas aeruginosa exhibited high potential for selected dye decolorization and hence it was used in subsequent experiments. The effect of dye concentration, pH, temperature, time, glucose and sodium chloride concentrations on decolorization were also studied to determine the optimal conditions required for maximum decolorization/degradation of selected dye by Pseudomonas aeruginosa. Maximum decolorization was observed at: 0.01 mg/L dye concentration, pH 10, temperature 45and#176;C, 0.1 mg/L glucose concentration, 0.1 mg/L sodium chloride concentration and 3 days incubation period at 37and#176;C. The metabolites formed after degradation by selected bacteria at optimum conditions were isolated and characterized by FTIR and mass spectrometry. In the mass spectra molecular ion peak was not observed and it was difficult to draw a conclusion from it. However, FTIR spectra provided some valuable information. The peaks at 1301.8 cm-1 for C-N and 1231.5 cm-1 for O-H stretch observed for original dye were completely absent in the decolorized products. The disappearance of C-N (part of the porphyrin ring system) peak in FTIR spectra shows that the porphyrin ring has been destroyed by bacteria. The extensive fragmentations in the mass spectra also confirm the degradation of the dye parental structure.
Synthesis and DFT Studies of Pyrimidin-1(2H)-ylaminofumarate Derivatives
Authors: Murat Saracoglu Murat Saracoglu , Zulbiye Kokbudak Zulbiye Kokbudak , M Izzettin Yilmazer and Fatma Kandemirli M Izzettin Yilmazer and Fatma Kandemirli
Published: November 2021

Pyrimidine derivatives have biological and pharmacological properties. Therefore, in this study we focused on the synthesis various Pyrimidine derivatives to make noteworthy contributions this class of heterocyclic compounds. In the present study, the new compounds (4-6) were obtained by the reactions of 1-amino-5-benzoyl-4-phenylpyrimidin-2(1H)-one (1), 1-amino-5-(4-methylbenzoyl)-4-(4-methylphenyl)pyrimidin-2(1H)-one (2) and 1-amino-5-(4-methoxybenzoyl)-4-(4-methoxyphenyl)pyrimidin-2(1H)-one (3) with dimethyl acetylenedicarboxylate. The structures of these compounds were proved by elemental analysis, FT-IR, 1H and 13C-NMR spectra. In addition to, quantum chemical calculations were made to find molecular properties of the pyrimidin-1(2H)-ylaminofumarate derivatives (4-6) by using DFT/B3LYP method with 6-311++G(2d,2p) basis set. Quantum chemical features such as EHOMO, ELUMO, energy gap, ionization potential, chemical hardness, chemical softness, electronegativity etc. values for gas and solvent phase of neutral molecules were calculated and discussed.
Study of Dielectric and Piezoelectric Properties of (1-x)PZT-xSFN Ceramics Prepared by Conventional Solid State Reaction Method
Authors: Fares Kahoul Fares Kahoul , Louanes Hamzioui Louanes Hamzioui , Abderrezak Guemache Abderrezak Guemache , Michel Aillerie and Ahmed Boutarfaia Michel Aillerie and Ahmed Boutarfaia
Published: November 2021

Modified-PZT ceramics with a formula (1-x)Pb(Zr0.53 Ti0.47)O3-xSr(Fe2/3, Nb1/3)O3 (doped with isovalent: Sr2+, acceptor: Fe3+ and Donor: Nb5+ ions) abbreviated as (1-x)PZT-xSFN binary system with varying x (x= 0.02, 0.04, 0.06, 0.08 and 0.10) located near the morphotropic phase boundary (MPB) were prepared by a traditional process in a solid state. All the samples were sintered at a temperature of 1200and#176;C during 2 h. The phase structure, the dielectric and piezoelectric properties of the system were studied. In-phase analysis used X-ray diffraction (XRD) at room temperature indicated that the structure of phase of sintered PZT-SFN ceramics was formed in single-phase with a crystalline structure tetragonal. Raman spectroscopy confirms the presence of this tetragonal phase. The optimum electrical parameters are obtained at 0.94Pb(Zr0.53Ti0.47)O3-0.06Sr(Fe2/3, Nb1/3)O3 system: kp= 66.10 %, d31= 145 pC/N, Qm= 473, tanδ= 1.11 %, and ɛr= 1009.
Removal of Acid Textile Dye from the Aqueous Solution by a New Adsorbent Obtained from Waste Cotton from the Garment Plant
Authors: Aleksandra Micic Aleksandra Micic , Dragan Djordjevic Dragan Djordjevic , Ivona Jankovic Castvan Ivona Jankovic Castvan , Nenad Cirkovic Nenad Cirkovic , Bratislav Todorovic Bratislav Todorovic
Published: November 2021

The paper investigates the possibility of removing acid dye from the aqueous solution by an adsorption process on new adsorbent prepared from waste cotton textile from the ready-made garment industry. It is a waste generated during the cutting of the layers of cotton knitwear, which is practically the product from the textile cutting process. The obtained adsorbent is a bulk material with heterogeneous porous particles, of ragged shapes. In particle interiors, there are pronounced cracks, cavities and channels that form the basis of microporous material. The qualitative and quantitative characterization of the obtained adsorbent shows that this is a relatively porous material where the carbon is dominant in the chemical composition. The results of textural properties of new adsorbent from cotton knitwear waste show different parameters which with their numerous values characterize the specific surface area, pore volume or pore diameter. It can be said that the obtained new adsorbent has micropores and small mesopores, which produce a high specific surface area. During adsorption, the longer contact time causes a greater amount of dye on the adsorbent, i.e. with the duration of the adsorption process the dye concentration in the solution decreases. A number of isotherms of two- (Langmuir, Freundlich and Jovanovic), three- (Toth, Sips and Radke-Prausnitz), and four-parameter models (Fritz-Schlunder and Marczewski-Jaroniec) were used to describe the adsorption process. The four-parameter isotherms are best covered by experimental points and most accurately describe the events of adsorption of acid dye on the surface and in the interior of the new adsorbent particles obtained from ready–made garment cotton waste. The results of this research suggest the possibility of practical application in the decolorization of the colored waste waters of the textile industry providing a contribution to protecting the environment from both an economic and a practical point of view.
Modified Zinc Oxide Nanoparticles for Corrosion Resistance Applications
Authors: Ali Dad Chandio Ali Dad Chandio , Muhammad Hamza Saleem Muhammad Hamza Saleem , Hasan Raza Khan Hasan Raza Khan , Iqra Naeem Hyder and Maryam Ali Iqra Naeem Hyder and Maryam Ali
Published: November 2021

Atmospheric corrosion is a big threat to the steel structures. This is because it compromises its structural integrity, aesthetic aspects and overall efficiency. An attempt has been made to counteract this through surface engineering of substrates including glass and steel by using modified zinc oxide nanoparticles to increase hydrophobicity. The synthesis of zinc oxide nanoparticles is carried out by using sol-gel method, thereafter these particles were modified by using stearic acid; a fatty acid. The zinc oxide nanoparticles were characterized by using X-ray diffraction analysis (XRD) which confirms the presence of hexagonal wurtzite structure. Moreover, the Scanning Electron microscopy (SEM) reveals the hexagonal wurtzite morphology of as prepared nanoparticles. Fourier transform infrared spectroscopy (FTIR) confirms the grafting of stearic acid on the surface of ZnO in bidentate form. The water Contact Angle obtained by using sessile drop method gives a statistical value of 140o which is of great interest due to higher water repellency and lower surface contact area. Finally, corrosion test was carried out on the coated steel substrate by means of conventional corrosion testing technique and it is observed that the coated sample decays three times slower than that of its bare steel counterpart.
Synthesis and Characterization of Zirconium Metal Complexes Derived from Benzene-1, 4-dicarboxylic acid
Authors: Hafiz Muhammad Arshad Hafiz Muhammad Arshad , Shazia Khurshid Shazia Khurshid , Shahzad Sharif Shahzad Sharif , Muhammad Ali Muhammad Ali , Muhammad Dilshad Muhammad Dilshad , Muhammad Ajmal Muhammad Ajmal , Sadaqat Ali and Hafiz Ishfaq Ahmad Sadaqat Ali and Hafiz Ishfaq Ahmad
Published: November 2021

Amongst organo-metallic frameworks (OMFs), the metallic framework having Zirconium metal indicate fascinating structural properties and excellent stability. Such organo-metallic frameworks (OMFs) function as a potential material for practical application. Even though these particular organo-metallic frameworks are in the early developmental stage but considerable advancements have been carried out recently. We studied the characterization of zirconium-based organo-metallic frameworks. We built Zr-based OMFs by four different synthetic ways. Initially, upgraded preparation under green and commercially feasible conditions has been carried out by modifying Zr-OMFs. Zirconium based OMFs having different structures are then classified and explained based on various organic ligands and zirconium-based secondary building units. We have synthesized the zirconium metal complexes; they have been characterized on the bases of FT-IR and CHNS analyzer. FT-IR results show binding of metal with the Benzene-1, 4-dicarboxylic acid [C6H4 (COOH) 2]. Zirconium metal can bind with the organic substances for the construction of a variety of complexes. From my research work, it is concluded that zirconium metal forms a polymeric complex with terephthalic acid. In which oxygen atoms of Terephthalic acid form bridging structure with the zirconium metal. Our study based on a particular type of OMF is likely expected to present guidance for in-depth exploration of OMFs towards practical applications. It is concluded that the metal-organic frameworks (MOFs) of zirconium metal have many applications in the field of chemistry, biology and other numerous fields of science
Experimental and Theoretical Studies of 2- (naphthalen-1-yl (piperidin-1-yl) methyl)phenol Compound
Authors: Yeliz Ula Yeliz Ula
Published: November 2021

The 2- (naphthalen-1-yl (piperidin-1-yl) methyl) phenol compound is an alkylaminophenol compound and has been experimentally synthesized by the Petasis reaction. In this study Structural analysis was carried out by FT-IR, NMR, UV-Vis spectroscopy. The high antioxidant value of the compound showed that it could be a potential biologically active drug. Theoretical data support all experimental analysis of the new compound. Comparisons were made by double method. For this purpose, DFT (B3LYP) and HF methods have been used with 6-311G ++ (d, p) set. Also, the compoundand#39;s electronic and structural properties (bond lengths, bond angles and dihedral angles), the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) energies, electrostatic potential (MEP), vibrational frequencies, Mulliken atomic charges, excitation energies, and oscillator strengths were calculated. As a result; the theoretical and experimental values were found to be compatible.
Pemanfaatan Media Interaktif Powerpoint untuk Meningkatkan Hasil Belajar Kognitif Muatan IPA Siswa Kelas V SDN Sumurwelut 1/438 Surabaya
Authors: Illahi Tiara Ayu Rahma , Rahmawati Ika , Setyawan Agung
Published: November 2021

Tujuan dari penelitian ini adalah mendeskripsikan peningkatan hasil belajar kognitif siswa kelas V melalui penggunaan media interaktif powerpoint pada muatan IPA di SDN Sumurwelut 1/438 Surabaya. Dalam penelitian ini yang menjadi subyek penelitian adalah siswa kelas V yang berjumlah 19 orang siswa pada tahun ajaran 2020/2021 dalam kaitan dengan hasil belajar siswa pada muata IPA. Sedangkan pihak terkait dalam penelitian ini adalah peneliti dan dibantu oleh observer atau kolaborator. Prosedur penelitian tindakan kelas ini direncanakan terdiri dari 2 siklus yang masing-masing meliputi empat langkah yaitu : perencanaan, pelaksanaan, pengamatan (observasi) dan refleksi. Pengumpulan data menggunakan teknik observasi, tes tertulis, wawancara, dan dokumentasi. Jenis data yang didapatkan adalah data kuantitatif hasil belajar muatan IPA kelas V SDN Sumurwelut 1/438 Kota Surabaya yang diambil dengan cara memberikan posttest pada setiap siklus. Data kualitatif yang didapatkan dari hasil observasi, wawancara, dokumentasi, aktivitas belajar siswa dan aktivitas guru dalam penerapan siklus. Hasil pra siklus ke siklus I dan siklus II yang meningkat awal mulanya raia- ratasiswa tuntas KKM pada pra siklus 22,85% menjadi 60% pada siklus I dan 94,29% pada siklus II. Kesimpulan penelitian ini yaitu hasil belajar kognitif siswa kelas V melalui penggunaan media interaktif powerpoint pada muatan IPA di SDN Manukan Kulon II/499 Surabaya meningkat.
Pengaruh Model Kemitraan Perajin Batik dan UMKM terhadap Kesejahteraan Perajin Batik Tanjung Bumi Bangkalan
Authors: Adhim Abdulloh Musa Syahrul , Nasik Khoirun
Published: November 2021

Tujuan di lakukannya penelitian ini adalah untuk mengetahui bagaimana pengaruh model kemitraan perajin batik dan UMKM terhadap kesejahteraan masyarakat perajin batik Tanjung Bumi Bangkalan. Penelitian ini dilakukan di beberapa tempat kelompok perajin batik yaitu kelompok Bajumi, Melate Poteh, Jokotole, Sulton dan Amin Jabir. Dengan 40 perajin batik sebagai responden yang terdiri dari 35 perajin perempuan dan 5 perajin laki-laki. Jenis Penelitian ini mengunakan metode penelitian kuantitatif dengan menggunakan data yang terbentuk angka yang diuji dengan statistik. Dalam teknik pengumpulan data yang dilakukan melalui studi kepustakaan dan studi lapangan yang meliputi wawancara, observasi, dokumentasi dan angket (kuesioner). Analisis data yang digunakan adalah uji validitas, uji reabilitas dan uji asumsi klasik. Berdasarkan analisis angket (kuesioner) yang menggunakan pengukuran skala likert dan hasil data yang diperoleh dari hasil analisis membuktikan bahwa variabel kemitraan memiliki pengaruh yang signifikan terhadap variabel kesejahteraan perajin batik Tanjung Bumi Bangkalan. Dengan dilihat dari nilai t hitung yaitu 2,248 > t tabel 2,026. Sedangkan variabel UMKM tidak memiliki pengaruh yang signifikan terhadap variabel kesejahteraan, dengan melihat nilai t hitung 0,876 < t tabel 2,026. Jadi, kerajinan batik  ini merupakan salah satu sumber penghasilan ekonomi bagi masyarakat lokal serta sebagai penopang pertumbuhan dan perkembangan perekonomian.
THE SKIN BARRIER IN SENSITIVE SKIN SYNDROME
Authors:   Department of Dermatology and Venerology, Faculty of Medicine, Medical University Varna, Bulgaria., Georgieva Filka
Published: November 2021

Background: Sensitive Skin Syndrome (SSS) is predominantly a self-defined condition without objective pathological findings. The syndrome presents with sudden and easily provoked flushes accompanied by unpleasant sensations like itching, pain or numbness in response to stimuli that usually do not cause such sensations. The intact skin is a barrier to uncontrolled water loss, plasma components and proteins from the organism. It is therefore assumed that one of the possible explanations of itching and other unpleasant sensations in SSS should be resulting in a dysfunctional skin barrier. Purpose: was to establish is there a dysfunction of the skin barrier in SSS patients. Objective and Methods: The presented study includes 64 females self-diagnosed with SSS and 45 females self-diagnosed with NSS (non-sensitive skin). Demographic data were collected from registers of Medico-Aesthetic Center “Medea” Varna from April 2017 till April 2019. Trans epidermal Water Loss (TEWL) and Hydration (H) of the epidermis in three different areas of the body were measured as an indicator of normal skin barrier functioning. Results: No significant differences in skin barrier indicators in SS compare to NSS were found. No visible pathological changes were found in patients according to the duration of SSS. A slight correlation between abnormal levels of TEWL and H and the severity of disease was obtained. Conclusion: All the reported and analyzed results indicate that disorders of the skin barrier are slightly connected with the severity and duration of SSS. This could be one of the explanations why adding topical treatment worsen rather than improve SSS. This is the first study in our country, which aims to measure the impact of changes in skin barrier on clinical characteristics of SSS.
PEMBINAAN MASYARAKAT USIA LANJUT MELALUI PEMERIKSAAN DAN PENYULUHAN KESEHATAN, SERTA MENGAJARKAN SENAM ANTIHIPERTENSI DI POSYANDU LANSIA DI WILAYAH KERJA PUSKESMAS PASUNDAN KELURAHAN JAWA SAMARINDA - KALIMANTAN TIMUR
Authors: Erin Yovita , Yani Samariah
Published: November 2021

Di Asia beban hipertensi sangat tinggi, hal itu terbukti dengan meningkatnya angka kematian akibat penyakit kardiovaskular di beberapa negara, bersamaan dengan rendahnya tingkat pengendalian dan kesadaran penyakit. Data di Puskesmas Pasundan cakupan penderita hipertensi khususnya di kelurahan Jawa sebesar 3.413 penderita, namun capaian penderita hipertensi periode bulan Januari sampai dengan Apri 2018 adalah 426 penderita (12,48%). Kegiatan pembinaan Lansia meliputi pemeriksaan tekanan darah, penyuluhan dan mengajarkan kepada para Lansia senam Antihipertensi. Berdasarkan pemeriksaan Tekanan darah diperoleh hasil bahwa: Tekanan darah Normal 32%, Prehipertensi 29%, Hipertansi Tahap satu 29% dan Hipertensi tahap dua sebesar 10%, sedangkan untuk pemeriksaan gula darah (>200mg/dl) sebanyak 71%. Penyakit hipertensi merupakan penyakit tidak menular, tetapi merupakan penyakit sebagai akibat dari proses degenerative dan pola hidup yang tidak sehat, semakin tahun meningkat dengan resiko komplikasi yang bervariasi dari ringan sampai berat. Meningkatkan upaya Promotif dan Preventif sehingga para Lansia memiliki pengetahuan dan kesadaran untuk mencegah terjadinya komplikasi.
Pandemic Covid-19: Impact to Malay Language Learning among the Students in Public Universities
Authors: Othman Shamsudin , Omar Rosmaria , Sabil Azhar Md
Published: November 2021

During the COVID-19 pandemic, social education moved from face to face to online learning to discourage large gatherings and crowds from catching the spread of the virus. This state of urgency involved all the students including university students. This paper aims to study the impacts of Pandemic Covid19 and identified the relationships between online learning, learning at home and self-management towards Malay Language learning among the students in public universities during MCO and 2) to develop a predictive model in the relationships between online learning, learning at home and self-management towards Malay Language learning among the students in public universities during MCO. Four variables which are online learning, learning at home, self-management, and Malay Language learning were analyzed using SPSS and AMOS. About 279 students from public universities were involved as respondents. Descriptive analysis, Correlation Pearson analysis and structural equation modeling (SEM) were used to answer the research objectives. An analysis of correlation Pearson showed that there are significant values derived from the relationship between online learning and Malay language learning (r=.578, p=.000). There is also a significant relationship between self-management and Malay language learning (r=.368, p=.000). However, there is no relationship between learning at home and Malay Language learning (r=.026, p=.294).  The predictive model achieved good fit values of RMSEA=.061, IFI=.937, CFI=.936, TLI=.925 and Chisq/df=2.001. The implementation of online learning as a new norm and platform in teaching and learning Malay Language among the students gave a positive impact in terms of technology usage. However, there are needs for improvement to be considered in providing a more useful platform to change from face to face in conventional ways similarly to advanced technology.  Meanwhile, the predictive model can serve as a source of reference in evaluating Malay language learning by using technology and other indicators for the future, for the sake of student’s achievement.
The Implementation of Teaching Supervision in Excellence Cluster Secondary Schools and Daily Secondary Schools
Authors: Zain Azrani Mohd , Asimiran Soaib , Razali Abu Bakar , Ahmad Nor Aniza
Published: November 2021

This study explores the implementation of teaching supervision in Excellence Cluster National Secondary Schools and Daily Secondary Schools. This study adopts the qualitative exploratory approach and involves eight study samples selected by purposive sampling. Methods of interview, observation and document analysis were used as the main tools in collecting the study data. The data collected were analysed using in-depth reading, open coding and axial coding. The results of the study as a whole show that the two categories of schools do not show differences in the characteristics studied in the implementation of teaching supervision in secondary schools. The study’s findings show that teaching supervision in Excellence Cluster Secondary Schools and Daily Secondary Schools is implemented through the devolution of power to middle leaders. Teaching supervision is guided by the teaching supervision form found in SKPMG2 standard 4. Teaching supervision in both school categories is done three times a year involving three phases. Moreover, teaching evaluation is done through direct observation in the classroom with full guidance on the teaching supervision form. The similarity in the implementation of teaching supervision is due to the same challenges faced by principals in both school categories, namely time constraints and administrative workload. The findings also show that supervisors use no specific approach for teaching supervision. The implication of this study is that it provides an insight into the implementation of teaching supervision by school administrators and that strengthening the skills and knowledge of middle leaders could improve teaching supervision effectiveness and positively impact the students, teachers and the school.
A Local Approach Toward Multicultural Counseling in Malaysia
Authors: Mohd Ayob Nurul Syahida , Hassan Siti Aishah , Mohamed Nordin Mohd Hamdan
Published: November 2021

Malaysia is a multicultural and multi-religious country. The importance of multicultural counseling has been widely recognized and discussed. Counselors need to be multiculturally-knowledgeable when dealing with multicultural clients. The effectiveness of counseling may likely be improved by integrating Malaysian approaches that are tailored to this country’s traditions and insights, into the current conventional counseling practices. Most of these counseling and psychotherapy theories are based on, and biased towards, the Euro-American culture. Novice counselors in particular frequently reported a lack of skills in dealing with culturally-diverse clients. Multicultural counseling competency is an evolutionary progress that is meant to achieve an effective treatment, and greater inclusion of minorities in mainstream society. Therefore, this paper highlights multicultural counseling competencies and the evolution of counseling in Malaysia. Using narrative method literature review, this paper presents local approaches toward counseling in Malaysia, based on various religions, which are specifically focused on an Islamic approach. This paper then compares and contrasts the local approaches with those of the conventional Western based counseling methods. Some recommendations that merit further investigation are highlighted for future studies.
5 giorni di antibiotico per le polmoniti non complicate sono sufficienti: i risultati di non inferiorità del SAFER RCT
Authors: Gruppo di lettura di Reggio Emilia
Published: November 2021

5 days of antibiotic for uncomplicated pneumonia is enough: the non-inferiority results of the SAFER RCT The most important guidelines for the treatment of community-acquired pneumonia (CAP) indicate amoxicillin as the drug of first choice, however there is a lack of evidence-based indications about the duration of this therapy. This study conducted in 2 emergency departments in Canada randomized 281 children aged 6 months to 10 years with CAP without the need for hospitalization to treatment with high-dose amoxicillin for 5 days versus a traditional 10 day therapy. In terms of clinical recovery, both groups presented comparable results. In fact, the “per protocol” analysis, recommended for a “non-inferiority” design, did not formally provide this result. The exclusively clinical recruitment criteria (any investigations were optional), well reflect the reality of primary care, and the results, albeit with some limitations, suggest that in uncomplicated CAP, brief therapy should be considered in the guidelines.
Initial diagnosis of blood disorders
Authors: Jędrzejczak Wiesław
Published: November 2021

Ostateczny wynik leczenia większości nowotworowych i nienowotworowych chorób krwi zależy od ich wczesnego wykrycia i szybkiego skierowania do hematologa. Oznacza to, że wstępna diagnostyka hematologiczna musi się odbywać na poziomie lekarza rodzinnego lub innego lekarza, który w trakcie diagnostyki innego schorzenia wykryje zaburzenia mogące sugerować chorobę krwi. Obecny artykuł dotyczy wykorzystania do tego celu triady badań: morfologii krwi, OB. i badania ogólnego moczu. Podano progi ilościowe zaburzeń, które powinny skutkować skierowaniem do hematologa, oraz wyjaśniono, dlaczego takie właśnie wartości przyjęto. Powszechne wykorzystanie tych informacji powinno skrócić czas od wystąpienia objawów chorób krwi do rozpoczęcia leczenia.
Unsung Heroes of a Tragic Generation
Authors: Swider Christopher
Published: November 2021

Praca jest rozszerzonym zapisem wykładu wygłoszonego podczas II Międzynarodowej Konferencji Związku Lekarzy Polskich w Chicago pt. „Patriotyzm. Dziedzictwo. Medycyna”, zorganizowanej 30.09.2019 r. z okazji 80. rocznicy wybuchu II wojny światowej i 75. rocznicy Powstania Warszawskiego [1]. Autor, syn polskiego małżeństwa lekarskiego, emerytowany profesor Columbia College Chicago, na przykładzie biografii swoich rodziców przedstawił walkę o ocalenie człowieczeństwa i humanistycznych wartości zawodu lekarza w warunkach nazistowskiego i komunistycznego totalitaryzmu. Opisał drogę życiową ojca – oficera wojska polskiego, psychiatry, więźnia sowieckich łagrów, uczestnika bitwy o Monte Cassino, organizatora pomocy psychiatrycznej dla polskich żołnierzy i weteranów wojennych we Włoszech oraz w Anglii i Stanach Zjednoczonych. Podobnie opisał drogę życiową matki – lekarza pediatry w Domu Baudouina w Warszawie, która z narażeniem własnego życia ratowała żydowskie dzieci przed zagładą. Zmuszona do opuszczenia stolicy, wraz z 6‑letnią córką nielegalnie przekroczyła kilka granic, by we Włoszech, w Weronie, połączyć się z mężem. Dzieląc jego żołnierski los, troskę o powiększającą się rodzinę postawiła ponad własną pracę zawodową lekarza. Tekst uzupełniają kopie dokumentów, m.in. odkrytych przez autora w Rosji podczas realizacji filmu „Children in Exile” o losie polskich dzieci zesłanych do sowieckich łagrów.
From special powers to legislating the lockdown: the Health Protection (Coronavirus, Restrictions) Regulations (Northern Ireland) 2020
Authors: Holder Daniel
Published: November 2021

The Health Protection (Coronavirus, Restrictions) Regulations (Northern Ireland) 2020 were made through temporarily inserted provisions by Westminster’s vast and rushed Coronavirus Act 2020. This itself limits duties to notify deaths to the coroner, despite Article 2 European Convention on Human Rights duties being particularly relevant to deaths in care homes and of frontline workers. The regularly amended March 2020 Northern Ireland regulations have themselves raised ‘legal certainty’ issues. Until June, official websites carried no accessible information as to their scope. Initial concerns on lack of clarity over matters such as driving for exercise gave way to greater controversy regarding the application of the regulations to the Black Lives Matter protests on 6 June 2020 through Police Service of Northern Ireland powers that had only been extended through an eleventh hour amendment the night before. The enforcement powers themselves are so widely drafted that they are reminiscent of the Special Powers Acts of the past. These issues are explored in this article.
Proposals for copyright law and education during the COVID-19 pandemic
Authors: Hudson Emily , Wragg Paul
Published: November 2021

This article asks whether the catastrophic impact of the COVID-19 pandemic justifies new limitations or interventions in copyright law so that UK educational institutions can continue to serve the needs of their students. It describes the existing copyright landscape and suggests ways in which institutions can rely on exceptions in the Copyright, Designs and Patents Act 1988 (CDPA), including fair dealing and the exemption for lending by educational establishments. It then considers the viability of other solutions. It argues that issues caused by the pandemic would not enliven a public interest defence to copyright infringement (to the extent this still exists in UK law) but may be relevant to remedies. It also argues that compulsory licensing, while permissible under international copyright law, would not be a desirable intervention, but that legislative expansion to the existing exceptions, in order to encourage voluntary collective licensing, has a number of attractions. It concludes by observing that the pandemic highlights issues with the prevailing model for academic publishing and asks whether COVID may encourage universities to embrace in-house and open access publishing more swiftly and for an even greater body of material.