bluuebunny/crossref_metadata_2025 huggingface dataset:
Shuffle Model of Differential Privacy: Numerical Composition for Federated Learning
Authors: Wang Shaowei , Zeng Sufen , Li Jin , Huang Shaozheng , Chen Yuyang
Published: February 2025

In decentralized scenarios without fully trustable parties (e.g., in mobile edge computing or IoT environments), the shuffle model has recently emerged as a promising paradigm for differentially private federated learning. Despite many efforts of privacy accounting for federated learning with many sequential rounds in the shuffle model, they suffer from generality and tightness. For example, existing accounting methods are targeted to single-message shuffle protocols (which have intrinsic utility barriers compared to multi-message ones), and are untight for the commonly used vector randomized response randomizer. As countermeasures, we first present a tight total variation characterization of vector randomized response randomizers in the shuffle model, which demonstrates over 20% budget conservation. We then unify the representation of single-message and multi-message shuffle protocols and derive their privacy loss distribution (PLD). The PLDs are finally composed by Fourier analysis to obtain the overall privacy loss of many sequential rounds in the shuffle model. Through simulations in federated decision tree building and federated deep learning, we show that our approach saves up to 80% budget when compared to existing methods.
Mechanical Efficacy Equivalence of W-Arch and Quad-Helix Orthodontic Arch Expansion Appliances: A Finite Element Study
Authors: Kamoi Aiko , Yokoi Yukiko , Yoshida Takuma , Otsuka Atsushi , Okafuji Norimasa
Published: February 2025

The quad-helix and W-arch are commonly used appliances for expanding the dental arch in orthodontic treatment. However, differences in performance between these two expanders remain unclear, and no guidelines exist for selecting one over the other. The purpose of this study was to investigate whether there were differences in dental arch expanding ability between these appliances. Maxillary arch expansions were simulated using the finite element method. The expander was assumed to be an elastic beam, while the teeth and alveolar bone were treated as rigid bodies. The periodontal ligament (PDL) was modeled as a nonlinear elastic material. The teeth moved in the same direction as the initial movement caused by the elastic deformation of the PDL. The right and left canines, premolars, and first molars were expanded symmetrically in either parallel or fan shapes. When the wire diameter of the W-arch was set to 0.032 inches its stiffness became equivalent to that of a quad-helix with a wire diameter of 0.036 inches. Canines and premolars were expanded through tipping movements. The molars initially tipped buccally, then became upright and moved bodily. Both expanders expanded the arch in almost the same manner. There was no difference in arch expansion ability between the W-arch made of 0.032-inch wire and the quad-helix made of 0.036-inch wire. The W-arch may be preferred as the first choice due to its simpler structure compared to the quad-helix.
Deterioration of White Tempera Mock-Ups Paints in a SO2-Rich Atmosphere
Authors: Rivas Teresa , Pozo-Antonio José Santiago , Jiménez-Desmond Daniel , Dionísio Amelia , Cardell Carolina
Published: February 2025

Historical tempera paints exposed to pollutant gases suffer chemical and mineralogical deterioration which manifests through physical changes. Knowledge about these changes is fundamental to develop strategies for preventive conservation of wall paintings. In this research, binary tempera mock-ups composed of calcite, gypsum or lead white mixed with a proteinaceous binder (i.e., egg yolk or rabbit glue) were exposed to an aging test by using SO2-rich atmosphere exposure to learn about the degradation mechanisms and forms related to the pigment–binder interaction. Reference (unaltered) and aged mock-ups were studied from a physical point of view, characterizing the morphological changes by using stereomicroscopy and profilometry, color variations by using spectrophotometry, gloss changes, and reflectance changes by using a hyperspectral camera. Also, mineralogical and chemical changes were studied by means of X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy with energy-dispersive X-ray spectroscopy. Egg-yolk-based paints showed higher chromatic changes than their counterparts made of rabbit glue binder. Also, sulfate and sulfite salts precipitated on the surface of the aged paints regardless of their binder, influencing the painting reflectance which subsequently increased. Egg-yolk-based mock-ups exhibited roughness increases while the rabbit-glue-based paints showed roughness reduction, with the exception of lead-white-based paints. Therefore, the important influence of the type of binder and the interaction between the binder and the pigment on the durability of tempera paints in atmospheres rich in SO2 was confirmed.
Impact of Climate Change on Informal Street Vendors: A Systematic Review to Help South Africa and Other Nations (2015–2024)
Authors: Sepadi Maasago Mercy
Published: February 2025

Climate change poses significant challenges to informal street vendors, particularly in urban settings where they operate in vulnerable environments. These challenges include economic instability, health risks, and sociopolitical exclusion, which are further exacerbated by extreme weather events and inadequate policy support. This review focuses on understanding these impacts by synthesizing lessons and exploring potential solutions from South Africa and other regions that could be implemented by governments and street vendors. A systematic review was conducted, following PRISMA guidelines, to synthesize findings from 48 studies published between 2015 and 2024. This review employed qualitative and quantitative analysis using thematic coding in ATLAS.ti and Microsoft Excel version 2024. Comparative analyses across regions and time periods were conducted to identify differences in impacts and adaptation strategies. Among the 48 studies, 52% were conducted in Africa and 50% in Asia, making these the most frequently represented regions in research on climate change and informal street vendors. Most of the publications were between 2021 and 2024 (52%). This review further highlights that climate change has led to significant economic losses, reduced working hours, and increased operational costs for informal vendors. Health impacts, such as respiratory illnesses and heat stress, are prevalent, particularly among vendors exposed to air pollution and extreme temperatures. Gender-specific vulnerabilities were noted, with women facing compounded challenges due to caregiving responsibilities and inadequate access to sanitation facilities. While Asian vendors have adopted technological solutions like mobile payment systems and cooling devices, these may not be currently feasible for South African vendors. Instead, tailored interventions that consider the local context and available resources are necessary to effectively support South African street vendors. Key recommendations include integrating vendors into urban resilience planning such as encouraging the use of cleaner and more sustainable transportation, improving access to healthcare, and providing financial support. Additionally, governments and communities should pilot the solutions identified in this review and publish their findings to inform future policies and practices.
Investigation of the Ionospheric Response on Mother’s Day 2024 Geomagnetic Superstorm over the European Sector
Authors: Paul Krishnendu Sekhar , Haralambous Haris , Moses Mefe , Oikonomou Christina , Potirakis Stelios M. , Bergeot Nicolas , Chevalier Jean-Marie
Published: February 2025

The present study examines the negative ionospheric response over Europe during two geomagnetic storms on 10–13 May 2024, known as the Mother’s Day geomagnetic superstorm. The first storm, with a peak SYM-H value of −436 nT, occurred in the interval 10–11 May, while the second, less intense storm (SYM-H~−103 nT), followed in the interval 12–13 May. Using data from four European locations, temporal and spatial variations in ionospheric parameters (TEC, foF2, and hmF2) were analyzed to investigate the morphology of the strong negative response. Sharp electron density (Ne) depletion is associated with the equatorward displacement of the Midlatitude Ionospheric Trough (MIT), confirmed by Swarm satellite data. A key finding was the absence of foF2 and hmF2 values over all ionosonde stations during the recovery phase of the storms, likely due to the coupling between the Equatorial Ionization Anomaly (EIA) crests and the auroral ionosphere influenced by the intense uplift of the F layer. Relevant distinct features such as Large-scale Travelling Ionospheric Disturbance (LSTID) signatures and Spread F were also noted, particularly during the initial and main phase of the first storm over high midlatitude regions. Regional effects varied, with high European midlatitudes exhibiting different features compared to lower European latitude areas.
Technology Innovation and Social and Behavioral Commitment: A Case Study of Digital Transformation in the Moroccan Insurance Industry
Authors: Abdallah-Ou-Moussa Soukaina , Wynn Martin , Kharbouch Omar , El Aoufi Sara , Rouaine Zakaria
Published: February 2025

Digital transformation (DT) has become an imperative for companies seeking to evolve in a constantly changing industrial ecosystem, driven by the continual development and application of innovative digital technologies. Nevertheless, the success rate of DT initiatives remains surprisingly low, which only serves to highlight the need for a deeper understanding of the factors that determine the success of these initiatives. This study adopts a quantitative methodological approach to address this challenge, focusing on the Moroccan insurance industry. First, a systematic literature review was undertaken to identify the key change dimensions and related factors that influence DT acceptance, at both individual and corporate levels, as well as the potential risks associated with the adoption of DT. A survey of 100 employees of insurance companies in Morocco was then undertaken to statistically establish the key factors that determine the success of DT in these companies. The research results reveal that planned behavioral factors, as well as the innovative features of digital technologies, exert a positive influence on the attitude toward the acceptance of DT. Furthermore, this positivity translates into greater personal acceptance of new technologies within the Moroccan organizations studied. Although this paper focuses on one industry sector in one country, the authors believe the results make a valid contribution to both theory and practice. The findings indicate a clear distinction between individual acceptance of innovation and acceptance at a social level, an approach that has scarcely been addressed in previous research. It also offers valuable insights for leaders and organizational managers seeking to succeed in their DT projects by highlighting key determining factors to effectively guide this complex process.
Comparison of Machine Learning Algorithms and Hybrid Computational Intelligence Algorithms for Rehabilitation Classification and Prognosis in Reverse Total Shoulder Arthroplasty
Authors: Vrouva Sotiria , Koumantakis George A. , Sopidou Varvara , Tatsios Petros I. , Raptis Christos , Adamopoulos Adam
Published: February 2025

Despite the increasing application of machine learning and computational intelligence algorithms in medicine and physiotherapy, accurate classification and prognosis algorithms for postoperative patients in the rehabilitation phase are still lacking. The present study was carried out in two phases. In Phase I, classification performance of simple machine learning algorithms applied on data of patients suffering of reverse total shoulder arthroplasty (RTSA), examining algorithms’ classification accuracy and patients’ rehabilitation prognosis. In Phase II, hybrid computational intelligence algorithms were developed and applied in order to search for the minimum possible training set that achieves the maximum classification and prognostic performance. The data included features like age and gender, passive range of available motion of all movements (preoperative and postoperative), visual analog pain scale (preoperative and postoperative), and total rehabilitation time. In Phase I, K-nearest neighbors (ΚΝΝ) classification algorithm and K-means clustering algorithm (GAKmeans) were applied. Also, a genetic algorithm (GA)-based clustering algorithm (GAClust) was also applied. To achieve 100% performance on the test set, KNN used 80% of the data in the training set, whereas K-means and GAClust used 90% and 53.3%, respectively. In Phase II, additional computational intelligence algorithms were developed, namely, GAKNN (Genetic Algorithm K-nearest neighbors), GAKmeans, and GA2Clust (genetic algorithm-based clustering algorithm 2), for genetic algorithm optimization of the training set. Genetic algorithm optimization of the training set using hybrid algorithms in Phase II resulted in 100% performance on the test set by using only 35% of the available data for training. The proposed hybrid algorithms can reliably be used for patients’ rehabilitation prognosis.
Bilateral Asymmetries of Plantar Pressure and Foot Balance During Walking, Running, and Turning Gait in Typically Developing Children
Authors: Liu Wei , Xu Liu , Wu Haidan , Wang Yile , Jiang Hanhui , Gao Zixiang , Jánosi Endre , Fekete Gusztav , Mei Qichang , Gu Yaodong
Published: February 2025

Biomechanical asymmetries between children’s left and right feet can affect stability and coordination, especially during dynamic movements. This study aimed to examine plantar pressure distribution, foot balance, and center of pressure (COP) trajectories in children during walking, running, and turning activities to understand how different movements influence these asymmetries. Fifteen children participated in the study, using a FootScan plantar pressure plate to capture detailed pressure and balance data. The parameters, including time-varying forces, COP, and Foot Balance Index (FBI), were analyzed through a one-dimensional Statistical Parametric Mapping (SPM1d) package. Results showed that asymmetries in COP and FBI became more pronounced, particularly during the tasks of running and directional turns. Regional plantar pressure analysis also revealed a more significant load on specific foot areas during these dynamic movements, indicating an increased reliance on one foot for stability and control. These findings suggest that early identification of asymmetrical loading patterns may be vital in promoting a balanced gait and preventing potential foot health issues in children. This study contributes to understanding pediatric foot biomechanics and provides insights for developing targeted interventions to support healthy physical development in children.
Clinical and Technological Evaluation of the Remineralising Effect of Biomimetic Hydroxyapatite in a Population Aged 6 to 18 Years: A Randomized Clinical Trial
Authors: Scribante Andrea , Cosola Saverio , Pascadopoli Maurizio , Genovesi Annamaria , Battisti Rebecca Andrea , Butera Andrea
Published: February 2025

The aim of this randomized clinical trial was to evaluate the efficacy of two different remineralising toothpastes in preventing dental caries and promoting oral health. Patients aged 6–18 years old with healthy and fully erupted first permanent molars (C1 and C2 DIAGNOdent scores) were enrolled and randomized into two groups according to the home-hydroxyapatite-based remineralising treatment used: the Trial group used zinc carbonate hydroxyapatite-based treatment (Biorepair Total Protective Repair), while the Control group used magnesium strontium carbonate hydroxyapatite conjugated with chitosan toothpaste (Curasept Biosmalto Caries Abrasion & Erosion). Dental and periodontal parameters were measured over a six-month period, including the DIAGNOdent Pen Index (primary outcome), BEWE Index, Plaque Index, Bleeding Score, Schiff Air Index, and ICDAS assessed with DIAGNOcam. A total of 40 patients were equally allocated in the two groups and finally analyzed. A significant reduction in the DIAGNOdent Pen score was reported in the Trial group after 1 month of treatment, while in the Control group, no significant change was found. The Trial group also showed a significant reduction in plaque levels after 3 months of treatment, while in the Control group, it occurred after 1 month. However, the Bleeding Score and Schiff Air Index showed no significant differences between the groups, suggesting that additional measures may be required to address gingival inflammation and hypersensitivity. The ICDAS index also showed no statistically significant changes, due to the limited duration of this study. Overall, zinc-hydroxyapatite-based toothpaste was more effective than magnesium strontium carbonate hydroxyapatite toothpaste in enhancing enamel remineralisation in the short-term period. The assigned treatments did not result in significant improvements in the oral indexes assessed in this study.
Maternal AGE Precursors During Lactation Alters Offspring Glycemic Homeostasis Early in Life
Authors: Saavedra Lucas P. J. , Francisco Flávio A. , Raposo Scarlett R. , Cavalcante Keilah V. N. , Buttow Nilza C. , Borges Stephanie C. , Gomes Rodrigo M. , Campos Hericles M. , Gonçalves Gessica D. , Piovan Silvano , Ghedini Paulo C. , Prates Kelly V. , Malta Ananda , Matafome Paulo , Mathias Paulo C. F. , Almeida Douglas L.
Published: February 2025

Background: Advanced glycation end-products (AGEs) are linked to the development of oxidative stress, insulin resistance, and impaired insulin secretion. Adverse early life conditions, such as exposure to AGEs and their precursors, may lead offspring to the development of metabolic dysfunction in adulthood. Nonetheless, the early impact in offspring metabolism by maternal intake of AGEs precursors during lactation is not known. Objective: Investigate early life metabolism of the offspring whose breastfeeding dams were orally exposed to AGEs precursor. Methods: Breastfeeding Wistar rats were daily treated with the glycation precursor methylglyoxal (MG—60 mg/kg of bodyweight) by gavage or saline 0.9% control (CO) until weaning. In vivo glycemic homeostasis in male offspring was assessed, followed by euthanasia for tissue sample collection for ex vivo assessments. Results: At weaning, MG offspring presented decreased bodyweight (p < 0.05), perigonadal (p < 0.01) and retroperitoneal (p < 0.01) fat. MG offspring presented decreased glucose tolerance (p < 0.05), lower basal insulinemia (p < 0.001), reduced high-glucose static insulin secretion (p < 0.05), and reduced pancreatic islet area (p < 0.05). Accordingly, MG offspring pancreas showed lower GSH and SOD activity (p < 0.05; p < 0.001, respectively) and increased MPO (p < 0.05) activity. Conclusions: The consumption of AGE precursors by breastfeeding dams impaired offspring pancreatic function and glycemic homeostasis early in life.
Hypothalamic Hamartomas: A Narrative Review
Authors: Mitrica Marian , Manole Aida Mihaela , Toma Mihai , Sirbu Octavian Mihai , Sirbu Anca Maria , Munteanu Alice Elena
Published: February 2025

Hypothalamic hamartomas (HH) are infrequent, non-neoplastic malformations of the hypothalamus with heterogeneous clinical features, with symptoms including gelastic seizures, central precocious puberty, and cognitive or behavioral deficits. This narrative review synthesizes current knowledge regarding the etiology, clinical manifestations, diagnostic advances, and therapeutic approaches for HH. Genetic insights highlight the role of postzygotic mosaicism and dysregulated Sonic Hedgehog signaling in HH development, emphasizing their relevance in potential therapeutic strategies. Diagnostic modalities such as MRI, PET, and SEEG are pivotal in identifying and characterizing HHs, enabling precise treatment planning. Therapeutic interventions span pharmacological, surgical, and neuromodulatory approaches. While surgical approaches, such as transcallosal resection or stereotactic radiosurgery, can offer considerable seizure control, newer modalities, such as laser interstitial laser thermal therapy (LITT) as well as stereotactic radiofrequency thermocoagulation, prioritize minimizing both cognitive and behavioral sequelae. The use of pharmacologic management and neuromodulation provides adjuvant benefits, specifically in drug-resistant epilepsy; despite progress, limitations still remain, including variability of outcomes and not enough long-term studies. This review underscores the need for multidisciplinary care and advanced research to optimize outcomes and improve the quality of life for patients with HH.
Navigating the Complexity of Psychotic Disorders: A Systematic Review of EEG Microstates and Machine Learning
Authors: Pacchioni Federico , Germagnoli Giacomo , Calbi Marta , Agostoni Giulia , Sapienza Jacopo , Repaci Federica , D’Incalci Michele , Spangaro Marco , Cavallaro Roberto , Bosia Marta
Published: February 2025

EEG microstates are brief, stable topographical configurations of brain activity that provide insights into alterations in brain function and connectivity. Anomalies in microstates are associated with different neuropsychiatric conditions, especially schizophrenia. Recent advances in both EEG techniques and machine learning point to the potential role of microstates as diagnostic markers for psychotic disorders. This systematic review aims to gather current knowledge on machine learning applied to EEG microstate analysis in psychotic disorders. Following PRISMA guidelines, we searched Scopus, PubMed, and Scholar databases, including 10 studies. Overall results show that EEG microstates can be used to accurately classify diagnoses within the psychosis spectrum, across all stages, outperforming models based on conventional EEG measures, with a prominent role of microstate D. One study also suggests that microstate anomalies may be directly linked to symptom severity. Integrating EEG microstates with machine learning shows promise in improving our understanding of psychotic disorders and developing more precise diagnostic tools.
Sustainable Design of a Tiny House: Using a Life Cycle Assessment Approach to Compare the Environmental Performance of Industrial and Earth-Based Building Systems
Authors: Dipasquale Letizia , Giuffrida Giada , Jorquera Silva Natalia , Pulselli Riccardo Maria , Caponetto Rosa
Published: February 2025

The increased concerns about climate change, diminishing natural resources, and environmental degradation call for deep research into new environmentally friendly building systems that use natural or recycled materials. The article presents an assessment of the environmental and climatic benefits associated with the construction of a tiny house made of quincha, a building system based on a wooden structure filled with locally sourced earth and straw. The tiny house is located in the Elqui Valley, in the Chilean region of Coquimbo, and it is designed to be compact, functional, comfortable, and efficient. The study uses a life cycle approach to assess the environmental impacts of building construction, maintenance, and end-of-life treatment, comparing the adopted quincha solution with four hypothetical scenarios using industrial, prefabricated, and/or synthetic construction materials currently adopted in the region. The thermal performance of all the analyzed solutions is also included in order to provide insights into the impact of the operational phase. This paper demonstrates that the quincha solution, in the face of lower thermal insulation compared to the other prefabricated solutions (the U-value of the quincha wall is 0.79 W/m2K while the U-value of the best prefabricated wall is 0.26 W/m2K), has higher thermal inertia (time lag (TL) and decrement factor (DF) are, respectively, 6.97 h and 0.60, while other systems have a TL below 4 h and DF higher than 0.81). For a quantitative environmental evaluation, the carbon footprint (global warming potential), water footprint, and embodied energy indicators are assessed through LCA, which takes into account the mass of the materials and their emission factors. The effectiveness of the quincha solution is also reflected in environmental terms; in fact, it is found to have the lowest carbon footprint (2635.47 kgCO2eq) and embodied energy (42.7 GJ) and the second-lowest water footprint (2303.7 m3). Moreover, carbon sequestration values, which are assessed by estimating the carbon contained in building systems using wood and straw, demonstrate that the quincha tiny house is the only solution that can theoretically reach carbon neutrality (with its carbon storage value at −5670.21 kgCO2eq).
The Impact of Different Excavation Support Structures on the Deformation and Stability of Adjacent Station and Tunnels
Authors: Mao Zhitong , Ding Tian , Hu Fengchao , Ye Shuaihua , Ding Linzhao , Zhang Xiaoning , Li Peiqiang , Li Nianxiang
Published: February 2025

This study uses the finite element software Midas GTS NX (2019), combined with actual engineering projects, to establish numerical models and analyze the impact of different support types (pile-anchor support and double-row pile support) on the excavation of foundation pits near metro station tunnels. The results indicate that under both support methods, the vertical displacement of the tunnel is the greatest at the interface between the station and the tunnel, with greater vertical displacement occurring under double-row pile support. Under pile-anchor support, the horizontal displacement of the tunnel reaches its maximum value during the sixth excavation stage, while under double-row pile support, the horizontal displacement increases steadily, and the overall displacement is small. The horizontal displacement under pile-anchor support is significantly greater than that under double-row pile support. For the station, the maximum vertical displacement under pile-anchor support is smaller than that under double-row pile support. The horizontal displacement under pile-anchor support exhibits a linear change, while under double-row pile support, the displacement continuously increases from the end of the foundation pit farther from the excavation to the end closer to it. The model tests are consistent with the numerical simulation results, verifying the correctness of the numerical simulation. This study can provide references for relevant engineering projects to ensure the safety and stability of metro structures.
Assessing the Efficiency of Integrating BIM and Blockchain to Improve Information Management for Mars Buildings: A SWOT-AHP Analysis
Authors: Javaherikhah Amirhossein , Lopez Mercedes Valiente , Sarvari Hadi
Published: February 2025

This research investigates integrating Building Information Modeling (BIM) and blockchain technology to enhance building information’s security, reliability, and accuracy in Martian environments. Given the unique challenges posed by extraterrestrial construction, this study evaluates the feasibility of this hybrid approach through a structured SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis. Expert inputs were collected through a comprehensive questionnaire identifying nine strengths, eight weaknesses, eight opportunities, and six threats to implementing BIM and blockchain technology in space projects. The Analytical Hierarchy Process (AHP) was used to prioritize these factors. Findings indicate that the strengths are cost calculation and budgeting (26.21), and the weaknesses are technology complexity (25.488). Increased productivity (19.16) is the most important criterion at the opportunity point, and defects in data security (20.68) are the most important at the threat point. The SWOT analysis places BIM and blockchain integration in a conservative strategy quadrant, indicating that the technology holds significant promise but requires further development and refinement. Ultimately, this research contributes to the growing knowledge about extraterrestrial construction technologies and provides a foundation for developing flexible and autonomous building systems for Martian habitats.
The Evolving Landscape in Multiple Myeloma: From Risk Stratification to T Cell-Directed Advanced Therapies
Authors: Besliu Carmen , Tanase Alina Daniela , Rotaru Ionela , Espinoza Jose , Vidal Laura , Poelman Martine , Juan Manel , de Larrea Carlos Fernández , Saini Kamal S.
Published: February 2025

Multiple myeloma is biologically and clinically a complex and heterogeneous disease which develops late in life, with the median age at the time of initial diagnosis being 66 years. In 1975, Durie and Salmon developed the first broadly adopted staging system in multiple myeloma, and in the ensuing decades, the risk stratification tools have improved and now incorporate different parameters to better predict the prognosis and to guide the treatment decisions. The International Staging System (ISS) was initially developed in 2005, revised in 2015 (R-ISS), and again in 2022 (R2-ISS). Tremendous progress has been achieved in multiple myeloma therapy over the past 25 years with the approval of immunomodulatory drugs, proteasome inhibitors, and anti-CD38 monoclonal antibodies, resulting in a major paradigm shift. The dysfunction of the innate and adaptive immune system, especially in the T cell repertoire, represents a hallmark of multiple myeloma evolution over time, supporting the need for additional therapeutic approaches to activate the host’s immune system and to overcome the immunosuppressive tumor microenvironment. Novel T cell-directed therapies include chimeric antigen receptor (CAR) T cell therapies and bispecific antibodies that leverage the immune system’s T cells to recognize and attack the tumor cells. Second-generation anti-BCMA CAR T cell therapies and bispecific antibodies that bind the tumor antigen BCMA or GPRC5D onto myeloma cells and CD3 on the T cell’s surface are currently available for the treatment of relapsed/refractory multiple myeloma. Despite impressive results obtained with currently approved treatments, multiple myeloma remains incurable, and almost all patients eventually relapse. Moreover, patients with extramedullary disease and plasma cell leukemia represent an unmet medical need that require additional strategies to improve the outcome. In this review, we provide an overview of the evolution of risk stratification and the treatment of multiple myeloma.
Genomic Characterization of Chordoma: Insights from the AACR Project GENIE Database
Authors: Hsia Beau , Bitar Gabriel , Alshaka Saif A. , Kim Jeeho D. , Valencia-Sanchez Bastien A. , Faraji Farhoud , Brandel Michael G. , Sato Mariko , Crawford John Ross , Levy Michael L. , Patel Vijay A. , Polster Sean P.
Published: February 2025

Background: Chordoma is a rare primary tumor originating from embryonic notochord remnants, with limited systemic therapeutic options due to a poor understanding of its genomic landscape. This study aims to characterize the genetic alterations in chordoma using a large national patient-level genomic repository, the AACR Project GENIE, to identify potential therapeutic targets and improve disease modeling. Methods: A retrospective analysis of chordoma samples was conducted using the AACR Project GENIE database. Targeted sequencing data were analyzed for recurrent somatic mutations, tumor mutational burden, and chromosomal copy number variations, with significance set at p < 0.05. Results: Frequent mutations were observed in genes associated with SWI/SNF complex affecting chromatin remodeling (SETD2, PBRM1, ARID1A). Mutations were also common among the TERT promoter regions, and cell cycle regulation (CDKN2A). Significant co-occurrences were identified among PBRM1, BRCA2, and KMT2D mutations. CDKN2A/B deletions were enriched in metastatic tumors, and pediatric cases demonstrated distinct mutation profiles compared to adults. Conclusions: This study provides a genomic profile of chordoma, identifying key mutations and potential therapeutic targets. These findings highlight the roles of chromatin remodeling and cell cycle pathways in chordoma biology, offering insights for future precision medicine approaches and therapeutic interventions.
Risk Factors and Long-Term Outcomes of Acute Kidney Disease in Hematopoietic Stem Cell Transplant—Cohort Study
Authors: Rodrigues Natacha , Branco Carolina , Sousa Gonçalo , Silva Manuel , Costa Cláudia , Marques Filipe , Vasconcelos Pedro , Martins Carlos , Lopes José António
Published: February 2025

Background: Acute kidney disease (AKD) is a recent definition reflecting ongoing physiopathological processes of an acute renal injury (AKI). Information on AKD in hematopoietic stem cell transplant (HSCT) is scarce and there is no available data on long-term outcomes. We aimed to determine the cumulative incidence of AKD in the first 100 days after HSCT; to identify risk factors for AKD in HSCT; and to determine the impact of AKD in 3-year overall survival and relapse-free survival in HSCT. Methods: A retrospective cohort study was conducted, considering AKD when AKI was present and the patient continued to meet the KDIGO criteria (creatinine and/or urinary output criteria) for 7 days or more. Survival analysis methods considering competing events were used for risk factors and disease-free survival, Cox proportional regression for overall survival, and stepwise regression methods for multivariable models. Results: We enrolled 422 patients. AKD incidence was 22.9% (95% CI: 19.2–27.4%). Higher body mass index (HR: 1.05, 95% CI 1.01–1.10; p = 0.034), HCT-CI score ≥ 2 (HR: 1.83, 95% CI 1.11–3.13; p = 0.027), allogeneic transplantation (HR:2.03, 95% CI 1.26–3.33; p = 0.004), higher C-reactive protein (HR:1.01, 95% CI 1.01–1.02; p < 0.001), and exposure to nephrotoxic drugs (HR: 4.81, 95% CI 1.54–4.95; p = 0.038) were independently associated with AKD. AKD had a significant impact on overall survival (HR: 1.75; 95% CI 1.27–2.39; p = 0.001). Conclusion: An awareness of the risk factors for AKD allows the identification of high-risk patients, enabling the timely implementation of preventive measures to alleviate the progression and impact of the disease.
The Role of Senescence in Experimental Periodontitis at the Causal Level: An in Vivo Study
Authors: Chu Xiaogang , Elashiry Mahmoud , Carroll Angelica , Cornelius Timothius Celine Joyce , Cutler Christopher W. , Elsayed Ranya
Published: February 2025

The occurrence and severity of periodontitis (PD) tend to increase with age, and yet the underlying mechanisms remain unclear. Immune senescence is known to be triggered in mice and humans as they age. Experimental PD in mice has been shown to induce senescence biomarkers p16 INK4a and p21, dysfunction of antigen-presenting cells (APCs), and activation of the senescence-associated secretory phenotype (SASP). However, the causal links of senescence to experimental PD are not yet established. This study aims to elucidate the role of senescence in experimental PD at a causal level. The P16-3MR mouse model harbors the p16INK4a (Cdkn2a) promoter, driving in vivo expression of synthetic Renilla luciferase, monomeric red fluorescent protein (mRFP), and herpes simplex virus-1 thymidine kinase (HSV-TK). This facilitates in vivo identification of p16 INK4a activation at the cellular level and the consequences of selective elimination of p16INK4a-positive cells by ganciclovir (GCV) treatment. Mice were treated with/without GCV for two weeks during ligature-induced PD. In vivo bioluminescence imaging quantified p16INK4a activation, while Western blot and immunofluorescence analyses assessed key senescence and inflammatory markers (p16, p21, p53, Cyclin D1, p-H2A.X, IL17, and IL1β). Alveolar bone volume was analyzed by micro-CT and histomorphometry. Our findings demonstrate that clearance of senescent cells in mice subjected to experimental PD alleviates inflammation and mitigates bone loss. These results suggest a causal role for senescence in PD pathology, raising the future prospect of senolytic agents for therapeutic intervention in PD.
Dose-Dependent PFESA-BP2 Exposure Increases Risk of Liver Toxicity and Hepatocellular Carcinoma
Authors: Kostecki Grace , Chuang Kiara , Buxton Amelia , Dakshanamurthy Sivanesan
Published: February 2025

Per- and polyfluoroalkyl substances (PFASs) are persistent and highly bioaccumulative emerging environmental contaminants of concern that display significant toxic and carcinogenic effects. An emerging PFAS is PFESA-BP2, a polyfluoroalkyl ether sulfonic acid found in drinking water and the serum of humans and animals. While PFESA-BP2-induced liver and intestinal toxicity has been demonstrated, the toxicological mechanisms and carcinogenic potential of PFESA-BP2 have remained relatively understudied. Here, we studied how different doses of PFESA-BP2 affect gene activity related to liver toxicity and the risk of liver cancer such as hepatocellular carcinoma (HCC) in mice exposed to PFESA-BP2 once daily through oral gavage for seven days. An analysis of key hepatic pathways suggested increased risk of hepatotoxicity as a result of PFESA-BP2 exposure. Increased oxidative stress response was associated with all concentrations of exposure. Liver toxicity pathways, including PXR/RXR activation and hepatic fibrosis, showed dose-dependent alteration with activation primarily at low doses, suggesting an increased risk of hepatic inflammation and injury. Additionally, an analysis of carcinogenic and HCC-specific pathways suggested PFESA-BP2-induced risk of liver cancer, particularly at low doses. Low-dose PFESA-BP2 exposure (0.03 and 0.3 mg/kg-day) was associated with an increased risk of HCC carcinogenesis, as indicated by the activation of tumor-related and HCC-associated pathways. In contrast, these pathways were inhibited at high doses (3.0 and 6.0 mg/kg-day), accompanied by the activation of HCC-suppressive pathways. The increased risk of HCC development at low doses was mechanistically linked to the activation of signaling pathways such as HIF, EGF, NOTCH4, HGF, and VEGF. Biomarkers linked to liver cancer risk, prognoses, and diagnoses were also identified as a result of exposure. Overall, our findings on liver carcinogenic and hepatotoxic pathway activation patterns suggest that PFESA-BP2 increases the risk of liver toxicity and HCC development, particularly at low doses.
Enhancing the Thermoelectric Performance of Bi2O2Se Ceramics via Multi-Element Doping
Authors: Zhao Hongquan , Ding Linan , Xu Yulang , Zeng Zhihao , Dong Songtao
Published: February 2025

Bi2O2Se, as the n-type counterpart of p-type BiCuSeO, has garnered considerable attention. The lower carrier concentration leads to reduced electrical conductivity, prompting extensive research efforts aimed at enhancing its electrical performance. This study prepared Bi2−3x(CeTiSn)xO2Se (x = 0, 0.02, 0.03, and 0.04) ceramics using a combination of high-energy ball milling and cold isostatic pressing techniques. Results demonstrated that the incorporation of multiple elements led to an increase in the carrier concentration within the Bi2O2Se system, thereby improving electrical conductivity. The electrical conductivity increased from 5.1 S/cm for Bi2O2Se to 154.1 S/cm for Bi1.88(CeTiSn)0.04O2Se at 323 K. Furthermore, the maximum power factor value of Bi1.88(CeTiSn)0.04O2Se was 112 μW m−1 K−2 at 763 K. Doping led to a slight increase in thermal conductivity. The figure of merit ZTmax value of Bi1.88(CeTiSn)0.04O2Se was ~0.16, marking a significant enhancement of about 1.45 times compared to that of the pure sample (~0.11).
How to Improve the Sliding Electrical Contact and Tribological Performance of Contacts by Nickel Coating
Authors: Ding Lu , Zhang Yafeng , Li Wei , Hu Yue , Cai Shaoxiong , Yu Jiaxin
Published: February 2025

The electrical contact and tribological performance of contacts are critical for the reliable transmission of electric power and signals. In this study, a nickel layer was applied as an underlayer at the interface, and the effects of its thickness and plating process on the electrical and tribological properties were systematically investigated. Results showed that the coefficient of friction (COF) was reduced due to the nickel layer. The wear loss significantly decreased as the nickel layer thickness increased from 0.5 μm to 2 μm. This is primarily due to the nickel layer reducing adhesive wear. Additionally, the electrical contact resistance (ECR) increased as the top coating was worn out, owing to a reduction in the effective conductive area. Furthermore, ECR, COF, and wear rate were further reduced when the nickel layer was deposited using electroless plating compared with electroplating. In conclusion, the wear resistance of electrical contacts can be improved by a thicker nickel layer or electroless plating. This study provides a theoretical basis for understanding the role of the nickel layer in improving sliding electrical contact and wear behaviors.
Reconstructing the Magnetic Field in an Arbitrary Domain via Data-Driven Bayesian Methods and Numerical Simulations
Authors: Pavlou Georgios E. , Pavlidou Vasiliki , Harmandaris Vagelis
Published: February 2025

Inverse problems are prevalent in numerous scientific and engineering disciplines, where the objective is to determine unknown parameters within a physical system using indirect measurements or observations. The inherent challenge lies in deducing the most probable parameter values that align with the collected data. This study introduces an algorithm for reconstructing parameters by addressing an inverse problem formulated through differential equations underpinned by uncertain boundary conditions or variant parameters. We adopt a Bayesian approach for parameter inference, delineating the establishment of prior, likelihood, and posterior distributions, and the subsequent resolution of the maximum a posteriori problem via numerical optimization techniques. The proposed algorithm is applied to the task of magnetic field reconstruction within a conical domain, demonstrating precise recovery of the true parameter values.
Advanced Surgical Approaches for the Rejuvenation of the Submental and Cervicofacial Regions: A Literature Review for a Personalized Approach
Authors: Borisenko Anastasiya S. , Sharobaro Valentin I. , Burkhonova Nigora S. , Avdeev Alexey E. , Ahmed Alsheikh Yousif M.
Published: February 2025

The quest for surgical advancements regarding the enhancement of the submental and cervicofacial regions has witnessed a remarkable upsurge in recent years. Informed patients are actively seeking sophisticated plastic surgery techniques to achieve comprehensive rejuvenation in these specific areas. Common complaints expressed by these patients include sagging of the jawline, the emergence of deep perioral wrinkles, and the formation of “marionette lines” within the lower third of the face. Furthermore, the manifestation of age-related signs, including neck laxity, submental adipose accumulation, “witch’s chin” deformity, and weakened platysma musculature, are common within this anatomical region. This literature review aims to summarize recent technical improvements, historical evolution, indications, postoperative care, and challenges for facial rejuvenation of the lower third of the face and neck. The application of minimally invasive procedures as part of a comprehensive approach for an aging face will also be discussed. In this article, an extensive search of the available literature was conducted using leading databases, including PubMed and MEDLINE, with the keywords “neck lift”, “platysmaplasty”, “facial rejuvenation”, “medial platysmaplasty”, “lateral platysmaplasty”, “neck rejuvenation”, and “cervicofacial rejuvenation”.
The Role of the DNA Methyltransferase Family and the Therapeutic Potential of DNMT Inhibitors in Tumor Treatment
Authors: Kim Dae Joong
Published: February 2025

Members of the DNA methyltransferase (DNMT) family have been recognized as major epigenetic regulators of altered gene expression during tumor development. They establish and maintain DNA methylation of the CpG island of promoter and non-CpG region of the genome. The abnormal methylation status of tumor suppressor genes (TSGs) has been associated with tumorigenesis, leading to genomic instability, improper gene silence, and immune evasion. DNMT1 helps preserve methylation patterns during DNA replication, whereas the DNMT3 family is responsible for de novo methylation, creating new methylation patterns. Altered DNA methylation significantly supports tumor growth by changing gene expression patterns. FDA-approved DNMT inhibitors reverse hypermethylation-induced gene repression and improve therapeutic outcomes for cancer. Recent studies indicate that combining DNMT inhibitors with chemotherapies and immunotherapies can have synergistic effects, especially in aggressive metastatic tumors. Improving the treatment schedules, increasing isoform specificity, reducing toxicity, and utilizing genome-wide analyses of CRISPR-based editing to create personalized epigenetic therapies tailored to individual patient needs are promising strategies for enhancing therapeutic outcomes. This review discusses the interaction between DNMT regulators and DNMT1, its binding partners, the connection between DNA methylation and tumors, how these processes contribute to tumor development, and DNMT inhibitors’ advancements and pharmacological properties.
Planktonic Foraminifera of the Middle and Upper Eocene Successions at the Northwestern and Northeastern Sides of the Nile Valley, Egypt: Stratigraphic and Paleoenvironmental Implications
Authors: Abu Bakr Safaa , Abd El-Gaied Ibrahim M. , Abd El-Aziz Sayed M. , Sayed Mostafa M. , Mahmoud Abdelaziz
Published: February 2025

This study deals with the biostratigraphic determination and paleoenvironmental reconstruction of the middle–upper Eocene sediments along the northwestern and northeastern banks of the Nile Valley, Egypt. The studied successions are classified into four rock units as follow: The Qarara (Lutetian–Bartonian), the El Fashn (Bartonian), the Gehannam, and the Beni Suef (Bartonian–Priabonian) formations. A total of eighty planktonic foraminifera species belonging to twenty-two genera and eight families are identified, and their vertical distribution enabled us to recognize four planktonic biozones, namely the Morozovelloides lehneri Zone (late Lutetian–early Bartonian), Orbulinoides beckmanni Zone (early Bartonian), Morozovelloides crassatus Zone (late Bartonian), and Globigerinatheka semiinvoluta Zone (late Bartonian–early Priabonian). The faunal assemblages characterizing these zones showed a great similarity with those recorded in the lower latitudes (tropical and sub-tropical) regions and correlated with the planktonic zones in the northern and southern Tethyan provinces. The appearance of Orbulinoides beckmanni distinguishes the early Bartonian period, its lowest occurrence defines the upper boundary of the Morozovelloides lehneri Zone, and its highest occurrence marks the lower boundary of the Morozovelloides crassatus Zone. The disappearance of the spinose forms of morozovellids and the large acarininids, besides the highest occurrence of Morozovelloides crassatus, defines the lower boundary of the Globigerinatheka semiinvoluta Zone. The middle/upper Eocene boundary is traced based on the last and first appearance of the marker planktonic species and located herein within the Globigerinatheka semiinvoluta Zone. The paleontological data, including the planktonic to benthic foraminiferal ratio (P/B), statistical analyses of different foraminiferal groups, and ternary plot diagrams in conjunction with the sedimentological features, indicate changes in the depositional settings, fluctuating between the inner to middle and outer neritic environment and the uppermost bathyal environment at some levels.