bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic analysis of Quercetin and its derivatives with Special Reference to anti-inflammatory property-Based on Network Pharmacology
Authors: Dutta Sharmistha , Prashanth Kumar H P , Ramesh Nijalingappa , Middha Sushil Kumar
Published: October 2022

The clinical success of phyto-chemicals and computationally assisted drug discovery-derived agents has stimulated the development of novel compounds for human illnesses. In the field of anticancer drug discovery, rational investigation has sped up the process. Quercetin and its derivatives have a long history of anti-inflammatory efficacy in pomegranate and other natural products, according to scientific evidence. Small structural alterations, for example, can drastically affect cell death behaviour and trigger inflammation, making it difficult to unravel the structure-activity relationship. As a result, our objective is to use a rational drug discovery approach to develop a mechanistic approach for quercetin and its derivatives, which will be compared to market anti-inflammatory medications utilising in-silico tools. Using the software Cytoscape, we created pharmacology networks of inflammatory proteins based on data acquired from several databases. The networks show how bioactives interact with molecular targets and how they relate to illnesses, particularly inflammation. Quercetin's network pharmacology study has shown novel connections between bioactive targets and possible inflammatory aetiology applications. The future prospect is to understand these chemicals in vitro and in vivo.
Effect of some Pseudomonas strains and Agave americana L. on wheat germination under salt stress
Authors: Mokrani Slimane , Nabti Elhafid
Published: October 2022

Currently, several efforts focus remedying the problem of agricultural soil salinity using eco-friendly strategies. This study aimed particularly the study of Triticum durum (durum wheat) seeds germination in the presence of Pseudomonas strains and hydro-alcoholic extract of Agave americana L. under saline stress conditions. The preliminary phytochemical screening of A. americana, phylogenetic identification and production of indole-3-acetic acid (IAA) by Pseudomonas strains, in vitro impact of hydro-alcoholic extract and Pseudomonas strains combination on salt stress resistance, preliminary effects of A. americana on Triticum durum germination and phytopathogenic fungi inhibition under salt stress were carried out using corresponding protocols. In in vitro trials, phytochemical screening revealed the richness of A. americana in polyphenols (1014.062±161.017 mM GA equivalent/g FW) and flavonoids (51.065±27.391 mg quercetin equivalent/g FW). The ability of Pseudomonas strains to produce the phytohormone indole-3-acetic acid (IAA) varied from 116.67±8.25 µg/ml to 857.14±80.50 µg/ml. The leaf extract of A. americana is an effective osmoprotectant that improves the resistance of the strain P1 Pseudomonas plecoglissicida to saline stress. In in vivo experiments, the extract of A. americana did not show any effect on the germination of wheat seeds. However, it effectively inhibited the contamination of seeds by phytopathogenic fungi during germination and saline conditions. Findings of the study revealed that Pseudomonas plecoglissicida and A. americana extract are very promising for the inhibition of phytopathogenic fungi and the alleviation of salt stress.
Regularity of degenerate k-Hessian equations on closed Hermitian manifolds
Authors: Zhang Dekai
Published: October 2022

In this article, we are concerned with the existence of weak

C

1
,
1

{C}^{1,1}

solution of the

k

k

-Hessian equation on a closed Hermitian manifold under the optimal assumption of the function in the right-hand side of the equation. The key points are to show the weak

C

1
,
1

{C}^{1,1}

estimates. We prove a Cherrier-type inequality to obtain the

C

0

{C}^{0}

estimate, and the complex Hessian estimate is proved by using an auxiliary function, which was motivated by Hou et al. and Tosatti and Weinkove. Our result generalizes the Kähler case proved by Dinew et al.
Optimized linear regression control of DC motor under various disturbances
Authors: Gökçe Celal Onur
Published: October 2022

In this study, an optimized linear regression controller is proposed for velocity control of DC motor. System is tested under disturbances of different types. Step, sinusoidal and trapezoidal functions are used as reference input. A linear single layer network of weights is used to calculate the necessary armature voltage by giving past measured velocity, past reference and certain amount of future reference as inputs. Training data are generated using Proportional Integral (PI) controller parameters which are optimized using particle swarm optimization (PSO). In this first phase of training, pseudo-inverse solution is used to find the coarse parameters of the network. These parameters give suboptimal results with low performance even lower than that of PSO-optimized PI controller. In the second phase of training, parameters of the network are fine-tuned using PSO algorithm again, this time for optimization of network parameters. Quite encouraging results including up to more than 1,500% increase in performance are obtained and reported.
Late Cretaceous adakitic intrusive rocks in the Laimailang area, Gangdese batholith: Implications for the Neo-Tethyan Ocean subduction
Authors: Li Deliang , Mai Yuanjun , Yang Wenguang , Zhu Lidong
Published: October 2022

The Gangdese batholith, emplaced from the Cretaceous to the Eocene in the southern Lhasa terrane of Tibet, provides critical constraints on the tectonic-magmatic evolution of the Neo-Tethyan Ocean and the India-Asia continental collision. In this article, we report new data for the Laimailang monzogranite in the southern Gangdese, including major and trace element analyses, zircon U–Pb dating, and in situ Hf isotope analyses. In situ zircon U–Pb dating of sample yielded Late Cretaceous ages (ca. 81 Ma). The monzogranite is characterized by relatively high-silica (≥56 wt% SiO2), Na-rich, and high-Al granitoids that are characterized by high Sr, low Y and HREE contents and strongly fractionated REE patterns, with no significant Eu anomaly, indicating that they are consistent with the definition of adakite. These monzogranite have high K2O (2.92–6.5%) and negative ε
Hf(t) (−2.1 to −5.4), suggesting that these rocks were likely derived from the partial melting of the lower continental crust. We conclude that the Laimailang rocks of adakitic affinity were derived due to the melting of the thickened lower continental crust in the late Cretaceous.
COVID-19: a viewpoint from hepatic perspective
Authors: Brizawasi Abhijeet , Ahirwar Ashok Kumar , Prabhat  , Kaim Kirti , Ahirwar Pradeep , Kumawat Rajani , Prasad Jitender
Published: October 2022

Coronaviruses as such are known since last century. The name is derived from their shape which has crown (corona) like radiating spikes. The recent one however is a different one from the Coronavirus involved in SARS (2002–2004) and MERS (2012) in being highly infectious. Initially COVID 19 had a high case fatality rate which has now decreased to a significant extent. Many cases of COVID 19 are asymptomatic with a significant number of positive cases developing a triad of fever, breathlessness and GI symptoms. Recent travel increases the probability of infection. The pathogenesis involves ACE 2 receptors. So, it has been found that there are more cases and mortality among hypertensive individuals. Even higher among the people who use ACE inhibitor in comparison to those who use other anti-hypertensive drugs. Treatment is usually symptomatic. Antiviral drugs and vaccines against COVID-19 are being used. Deranged liver enzymes are common in COVID-19, however, serious liver injury is not much documented. Liver injury is either due to disease itself or due to antiviral drugs. Extra care like strict social distancing, avoiding unnecessary contact is needed for those with autoimmune hepatitis, liver cancer and those who are in immunosuppression because of a scheduled or already liver transplant. Further research is definitely needed in this field. The upcoming researches should also focus on liver injuries associated with disease course and derangements arising as side effects of treatment of COVID-19.
The smallest dislocated microduplication of Xq27.1 harboring SOX3 gene associated with XX male phenotype
Authors: Oroz Maja , Vičić Ana , Požgaj Šepec Marija , Karnaš Helena , Stipančić Gordana , Stipoljev Feodora
Published: October 2022

Objectives

Approximately 90% of “XX males” are positive for SRY. However, there are isolated cases of sex reversal associated to other genes in male-determining pathway.

Case presentation

We describe a 1.3-old patient with 46,XX karyotype, male phenotypic gender and cryptorchidism. Microarray analysis revealed a de novo 273 kb duplication in the Xq27.1 region that contains SOX3. FISH with probe specific to SOX3 confirmed a unique genomic location of this duplication, dislocated proximal to the centromere of the X chromosome.

Conclusions

This rare genetic condition was described in few other isolated cases that have associated SOX3 genetic rearrangements and DSD. Microarray and genome-wide-sequencing presents important part in routine diagnostics, and in delineation of other sex-determination-pathway genes in sex reversal disorders.
Severe consumptive hypothyroidism in hepatic hemangioendothelioma
Authors: Walther Antonia , Häberle Beate , Küppers Julia , Lurz Eberhard , Schmid Irene , Schmidt Heinrich , Dubinski Ilja
Published: October 2022

Objectives

Consumptive hypothyroidism may occur in hepatic hemangioendothelioma. The altered expression of deiodinases inactivates peripheral thyroid hormones. As a result, serum levels of free triiodothyronine and free thyroxine are reduced to varying degrees. There are no established recommendations for the dosage of sirolimus for this particular indication. We describe for the first time the course of treatment with low-dose sirolimus.

Case presentation

We present a 5-week-old infant with hepatic hemangioendothelioma and severe consumptive hypothyroidism. Due to hepatic infiltration he showed signs of right heart strain. Therapy of hemangioendothelioma was initiated with propranolol and, in the absence of response, methylprednisolone was added. Treatment was continued with low-dose sirolimus (due to side effects) and propranolol. Hypothyroidism was managed with levothyroxine and liothyronine.

Conclusions

Consumptive hypothyroidism due to cutaneous hemangioma and hepatic hemangioendothelioma can be managed with propranolol and low-dose sirolimus. Treatment of severe hypothyroidism may require a combinational therapy by substitution of both T3 and T4.
United States Policy in the Eastern Mediterranean
Authors: Yegin Mehmet
Published: October 2022

This article examines the United States’ approach to the Eastern Mediterranean. Despite reducing its military commitment and deciding to pursue a policy less inclined to use military force, the US has neither withdrawn its military presence completely nor abandoned its allies in the region. Instead, it has recalibrated its involvement, limiting its engagement and related costs to reallocate resources to the Asia Pacific. However, the US still seeks to prevent Russia and China from co-opting its partners in the Eastern Mediterranean, just as it strives to combat terrorism there. So, Washington seeks to maintain the status quo provided by the current balance of its regional allies and to prevent Russia and China from establishing strategic relations with one or more of those regional actors. However, the US track record in achieving those objectives is mixed, especially when comparing the performances of different administrations.
Conflicts and Global Powers in the Eastern Mediterranean. An Introduction
Authors: Axt Heinz-Jürgen
Published: October 2022

Conflicts in the Eastern Mediterranean have a long history, and recently supposed energy reserves have fuelled confrontations. Many studies are available that mainly analyse the strategies of the littoral states of the Mediterranean. This special issue enlarges the perspective by also including the global powers the EU, the United States, Russia, and China in the analysis. The role of the regional power Turkey is also in focus here. Importantly, Russia’s war against Ukraine must be taken into account. Since the Russian president has been using gas as a weapon and trying to put pressure on Europe in particular, the relevance of the energy reserves in the Eastern Mediterranean must be reassessed. After the end of the Cold War, the actors on the global political level promised a rule-based world order. This promise has been severely challenged, however, after Russia’s invasion of Ukraine which makes it necessary to reassess the relations between the global powers and the Mediterranean countries.
The Age of Reason: Functional Brain Network Development during Childhood
Authors: Tooley Ursula A. , Park Anne T. , Leonard Julia A. , Boroshok Austin L. , McDermott Cassidy L. , Tisdall Matthew D. , Bassett Dani S. , Mackey Allyson P.
Published: October 2022

Human childhood is characterized by dramatic changes in the mind and brain. However, little is known about the large-scale intrinsic cortical network changes that occur during childhood because of methodological challenges in scanning young children. Here, we overcome this barrier by using sophisticated acquisition and analysis tools to investigate functional network development in children between the ages of 4 and 10 years (n=92; 50 female, 42 male). At multiple spatial scales, age is positively associated with brain network segregation. At the system level, age was associated with segregation of systems involved in attention from those involved in abstract cognition, and with integration among attentional and perceptual systems. Associations between age and functional connectivity are most pronounced in visual and medial prefrontal cortex, the two ends of a gradient from perceptual, externally oriented cortex to abstract, internally oriented cortex. These findings suggest that both ends of the sensory-association gradient may develop early, in contrast to the classical theories that cortical maturation proceeds from back to front, with sensory areas developing first and association areas developing last. More mature patterns of brain network architecture, controlling for age, were associated with better visuospatial reasoning abilities. Our results suggest that as cortical architecture becomes more specialized, children become more able to reason about the world and their place in it.

SIGNIFICANCE STATEMENTAnthropologists have called the transition from early to middle childhood the “age of reason”, when children across cultures become more independent. We employ cutting-edge neuroimaging acquisition and analysis approaches to investigate associations between age and functional brain architecture in childhood. Age was positively associated with segregation between cortical systems that process the external world and those that process abstract phenomena like the past, future, and minds of others. Surprisingly, we observed pronounced development at both ends of the sensory-association gradient, challenging the theory that sensory areas develop first and association areas develop last. Our results open new directions for research into how brains reorganize to support rapid gains in cognitive and socioemotional skills as children reach the age of reason.
Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature
Authors: Więcek Małgorzata , Gawlik Jakub , Nowak Zuzanna , Gawlik Aneta
Published: October 2022

Loss of fertility is one of the most important concerns facing Turner syndrome (TS) patients as they transition into adult health care. Due to the limited and rapidly decreasing ovarian reserve, many TS patients require fertility preservation (FP) techniques to preserve their reproductive potential until they are ready to pursue procreation. One has to also remember about the additional risks connected with pregnancy in TS patients. In order to determine the optimal time for introducing FP techniques and decrease the chance of an unnecessary intervention, markers and procedures assessing ovarian reserve have been developed. The exposure to potential cardiovascular complications should be determined before FP to avoid unnecessary procedures in patients with potential contraindications to pregnancy. The aim of the present review is to answer the following three questions important for successful preservation of fertility and safe pregnancy in TS: which markers of ovarian reserve should be used as selection criteria for FP? Which methods of FP are the safest and most effective? Are there any cardiovascular contraindications to FP? For each of those questions, separate literature searches have been conducted. A total of 86 articles have been included in this review: 34 for the first question, 35 for the second, and 17 for the third. Ovarian reserve markers and cardiovascular contraindications to pregnancy should be established before FP; hoverer, there are no unambiguous indicators as to which patients should be disqualified from the FP and more evidence is needed in this subject.
OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Oxidative stress and in vitro ageing of the post-ovulatory oocyte: an update on recent advances in the field
Authors: Martin Jacinta H , Nixon Brett , Cafe Shenae L , Aitken R John , Bromfield Elizabeth G , Lord Tessa
Published: October 2022

In brief

Post-ovulatory ageing of oocytes leads to poor oocyte and embryo quality as well as abnormalities in offspring. This review provides an update on the contributions of oxidative stress to this process and discusses the current literature surrounding the use of antioxidant media to delay post-ovulatory oocyte ageing.

Following ovulation, the metaphase II stage oocyte has a limited functional lifespan before succumbing to a process known as post-ovulatory oocyte ageing. This progressive demise occurs both in vivo and in vitro and is accompanied by a deterioration in oocyte quality, leading to a well-defined sequelae of reduced fertilisation rates, poor embryo quality, post-implantation errors, and abnormalities in the offspring. Although the physiological consequences of post-ovulatory oocyte ageing have largely been characterised, less is known regarding the molecular mechanisms that drive this process. This review presents an update on the established relationships between the biochemical changes exhibited by the ageing oocyte and the myriad of symptoms associated with the ageing phenotype. In doing so, we consider the molecular events that are potentially involved in orchestrating post-ovulatory ageing with a particular focus on the role of oxidative stress. We highlight the mounting evidence that oxidative stress acts as an initiator for a cascade of events that create the aged oocyte phenotype. Specifically, oxidative stress has the capacity to disrupt mitochondrial function and directly damage multiple intracellular components of the oocyte such as lipids, proteins, and DNA. Finally, this review addresses emerging strategies for delaying post-ovulatory oocyte ageing with emphasis placed on the promise afforded by the use of selected antioxidants to guide the development of media tailored for the preservation of oocyte integrity during in vitro fertilisation procedures.
Objeción de conciencia al servicio militar obligatorio en Colombia: debates sobre su fundamentación jurídica
Authors: Martínez Ramírez Juan Manuel
Published: October 2022

Este artículo analiza, desde una perspectiva consti[1]tucional, la fundamentación jurídica de la objeción de conciencia al servicio militar obligatorio en Colombia y propone una metodología alternativa para su valoración. Para ello, primero se hace un análisis jurisprudencial de la sentencia C-370/2019, la cual perfiló “la noción de la objeción de conciencia como un derecho constitucional nominado y autónomo”, regido por las reglas definidas a partir de la sentencia C-728/2009. En segundo lugar, se propone una lectura crítica a dichas reglas jurisprudenciales, evidenciando importantes vacíos argumentativos de la figura y la metodología planteada por la Corte Constitucional de Colombia para resolver las solicitudes particulares de objeción. En tercer lugar, se presenta “la objeción de conciencia” como herramienta que materializa derechos fundamentales, como la libertad de conciencia, y que tiene como núcleo la tensión entre bienes jurídicos tutelables por el ordenamiento. Posteriormente, se propone resolver la mencionada tensión jurídica mediante la aplicación judicial de una metodología basada en el test de proporcionalidad. Finalmente, se enfatiza en la importancia que la metodología propuesta tiene para el contexto nacional, pues al igual que la desobediencia civil para Biondo (2016) y debido al marco histórico del conflicto armado colombiano, la objeción de conciencia al servicio militar puede tener un carácter estabilizador del ordenamiento jurídico. En conclusión, valorar las solicitudes de objeción de conciencia con base en la metodología propuesta permitiría evaluar más objetivamente la tensión entre bienes jurídicos tutelables, diferenciando así el tratamiento de las objeciones que pueden jugar un rol estabilizador del ordenamiento.
Reforma al CPACA y su incidencia adjetiva en materia tributaria
Authors: Gómez Monterroza Luis Adrián
Published: October 2022

En este artículo se presentan los resultados del monitoreo y recolección de datos sobre la reforma del código de procedimiento administrativo y de lo contencioso administrativo -en adelante CPACA- en relación con su incidencia en materia tributaria. En este sentido, tras un seguimiento a la exposición de motivos del proyecto de ley 07 del 20 de julio de 2019 -hoy ley 2080 de 2021- en contraste con el texto original de la ley 1437 de 2011, la ley 1564 de 2012 y el estatuto tributario nacional -en su parte adjetiva-, se identificaron los efectos de las nuevas disposiciones normativas en asuntos tributarios, los cuales fueron objeto de investigación, crítica, análisis y reflexión jurídica.
Un modelo actancial para el estudio de la jurisprudencial constitucional en Colombia: una mirada desde cuatro derechos fundamentales de la población privada de la libertad
Authors: Navajas Barrera Diego Alain
Published: October 2022

La jurisprudencia constitucional en Colombia es principalmente analizada mediante el uso de técnicas de análisis jurisprudenciales tradicionales que se basan en el estudio del precedente judicial para tres fines particulares: la aplicación del derecho en casos concretos, la interpretación de disposiciones legales, y suplir vacíos normativos en ausencia de legislación. De otro lado, es poco común el estudio de la jurisprudencia desde otras técnicas de análisis cualitativo de datos. Es en ese sentido que, los avances de investigación presentados en este artículo intentan mostrar cómo estudiar la jurisprudencia constitucional desde un enfoque semiótico haciendo uso de la herramienta analítica de los modelos actanciales.

Concretamente se busca aplicar el modelo actancial de A.J. Greimas sobre la jurisprudencia constitucional de cuatro derechos fundamentales de la población privada de la libertad en Colombia:  derecho a la unidad familiar, a la libertad religiosa y de cultos, a la libertad sexual-visita íntima y derecho al trabajo penitenciario. Para finalmente obtener una estructura actancial que dé cuenta de los elementos narratológicos presentes en las sentencias judiciales cuando estas son estudiadas desde la semiótica como un relato narrativo.
Changing quality of recycled fiber material. Part 1. Factors affecting the quality and an approach for characterisation of the strength potential
Authors: Keränen Janne T. , Retulainen Elias
Published: October 2022

The paper recycling sector has undergone major changes in recent years, particularly regarding the quantity and quality of various materials processed. Material originating from board grades will increasingly dominate the recycling market as the use of printing papers decreases and the amount of non-fiber elements increases. Users of recycled fiber material have to overcome three main challenges: price, quality, and availability. This paper focuses on the quality dilemma in terms of measurement needs and possibilities from the user viewpoint. It includes a discussion of the factors causing deterioration in the quality of paper used for recycling. Today, the average fiber age is low compared to what the fibers can tolerate. Therefore, the characteristic phenomena in the paper recycling loop are not caused by the degradation of individual fibers, but by a blending process in which different fiber grades and non-fiber components are blended in a non-optimal way. A novel method is introduced in this article for evaluating the quality of recycled fiber material using a new parameter, the fiber integrity value. Part 2 of this paper will focus on the application of this new parameter and demonstrates its correlation with paper properties.
Development of Energy Supply Infrastructure Based on Industry 4.0 (on the Example of Ukraine and Turkey)
Authors: Trofymenko Olena , Voitko Serhii , Naraievskyi Serhii
Published: October 2022

The object of research was to identify the field of renewable energy for ensuring the process of gradual transition from traditional energy to carbon-free technologies. The article compares the opportunities for energy development, taking into account current trends in sustainable development. The conducted analysis of energy resources in the section of renewable energy is based on the processing of available sources of analytical and statistical information. The study investigates the structure and features of the functioning of the energy sector of Ukraine and Turkey. There have been revealed several common problems of functioning of energy spheres in Ukraine and Turkey. The article investigates the possibilities of using technological solutions and principles of Industry 4.0 in ensuring energy security through the development of the electric car market. The analysis consists of calculations of the efficient functioning of solar and wind energy for Ukraine and Turkey. The article provides recommendations for the development of possible mutually beneficial cooperation between Ukraine and Turkey in the field of renewable energy.
Functional Inorganic Materials
Authors: Kareiva Aivaras , Januškevičius Justinas , Inkrataitė Greta
Published: October 2022

-
Representative and highly sensitive express method of measurement of f-activity
Authors:   Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine, Shchepkin Yu.G. , Mazina N.I. , Slisenko V.I. , Stratilat D.P.
Published: October 2022

The method for determination of f-activity (spontaneous fission) of samples based on a combination of multiplicity spectrometry, measurement of radiation energy, and registration of time of long-range fission products is considered. The method is representative, highly sensitive, and fast. The minimum determined value of the specific activity is 1.4⋅10-3 Bq/g.
Війна і мир в Україні: шляхи до реальної перемоги і розвитку
Authors: Пирожков Сергій Іванович , Хамітов Назіп Віленович
Published: October 2022

Розглянуто питання критеріїв реальної перемоги України у війні. В координатах метаантропології і метаантропологічного потенціалізму показано, що одним з основоположних критеріїв може бути збереження і розвиток цивілізаційної суб’єктності України. Глобальним критерієм перемоги, що є одночасно її глобальним смислом та значенням і впливає на рішення країн Заходу про надання економічної й військової допомоги нашій країні, може бути лише перемога нового гуманізму над неототалітаризмом, який сьогодні загрожує не лише Україні, а й усьому світу. Новий гуманізм, який зумовлює реальну перемогу України і підтримку світу, — це не лише гуманізм співчуття до Іншого, а й гуманізм консолідації і співтворчості з Іншим. Саме такий новий гуманізм ціннісно поєднує країни Європи та Євроатлантики, в цивілізаційний простір яких все більше входить Україна.
Богдан Йосипович Пташник — вчений, патріот і громадянин
Authors: Кушнір Роман Михайлович , Пелих Володимир Олександрович , Симотюк Михайло Михайлович
Published: October 2022

Статтю присвячено 85-річчю від дня народження відомого українського математика, автора фундаментальних досліджень з теорії некласичних крайових задач для рівнянь із частинними похідними, лауреата премії ім. М.О. Лаврентьєва НАН України (2007) доктора фізико-математичних наук (1989), професора (1990), члена-кореспондента НАН України (2003) Богдана Йосиповича Пташника.
Optimizing Pediatric Patient Safety in the Emergency Care Setting
Authors: Joseph Madeline M. , Mahajan Prashant , Snow Sally K. , Ku Brandon C. , Saidinejad Mohsen ,   COMMITTEE ON PEDIATRIC EMERGENCY MEDICINE, the AMERICAN COLLEGE OF EMERGENCY PHYSICIANS PEDIATRIC EMERGENCY MEDICINE COMMITTEE, and the EMERGENCY NURSES ASSOCIATION PEDIATRIC COMMITTEE
Published: October 2022

Patient safety is the foundation of high-quality health care and remains a critical priority for all clinicians caring for children. There are numerous aspects of pediatric care that increase the risk of patient harm, including but not limited to risk from medication errors attributable to weight-dependent dosing and need for appropriate equipment and training. Of note, the majority of children who are ill and injured are brought to community hospital emergency departments. It is, therefore, imperative that all emergency departments practice patient safety principles, support a culture of safety, and adopt best practices to improve safety for all children seeking emergency care. This technical report outlined the challenges and resources necessary to minimize pediatric medical errors and to provide safe medical care for children of all ages in emergency care settings.
Biotechnological methods for pulping copoazú (Theobroma grandiflorum (Wild. ex Spring) Schum) seed and their influence on the fermentation stage
Authors: Criollo nuñez Jenifer , Sandoval-Aldana Angélica Piedad , Criollo-Cruz Dagoberto , López-Hernández Martha del Pilar
Published: October 2022

Copoazú is a fruit originated from Colombian Amazon belonging to Theobroma genus, which includes species such as cacao raw material for chocolate. Both species presented similar processing stages, with different process parameters due to the physical qualities of each fruit. Enzymatic, mechanical, and combined methods for pulping copoazú seeds and their effect on the biochemical dynamics of fermentation were evaluated. The pulping treatments evaluated were manual (Ma), mechanical (Me), enzymatic (Ez), and enzymatic-mechanical (Ez-Me), considering the yield as a response variable. The results showed higher percentages of pulp recovery for enzymatic, enzymatic-mechanical, and manual treatments with 61.01%, 66.80%, and 65.71%, respectively. The dynamics of the fermentation showed a reduction of seven to four days for the fermentation stage with the enzymatic treatments, registering up to 85.3% of well-fermented grain at the end of this phase.
Analyzing PM10 concentrations and their trace elements in southern Lima, Peru: a case study from March 06th to 13th, 2020
Authors: Sánchez-Ccoyllo Odón R. , Gala-Barraza Yeiko , Arratea-Morán Jessica
Published: October 2022

En esta investigación se midieron las concentraciones de PM10 en la Universidad Nacional Tecnológica de Lima Sur (UNTELS), ubicada en Lima Sur, del 06 al 13 de marzo de 2020. Para examinar que las concentraciones de aerosol-PM10 se han aplicado dos técnicas que son: trayectoria de parcela de aire de llegada de PM10 y el análisis de clúster a los metales traza para detectar el transporte de aerosol-PM10 desde lugar remoto a Lima Sur y encontrar las fuentes-locales de elementos-partículas respectivamente, por primera vez en Lima Sur. La trayectoria de llegada de PM10 en UNTELS ha demostrado que los valores altos de las concentraciones de PM10 están asociados con la masa de aire que se origina desde el noroeste de Lima, sin embargo, los valores bajos de las partículas de PM10 están relacionados con la alta humedad de parcela de aire que se originan en el Sur-Sureste (SSE) del Océano Pacífico.
Dynamic Modeling Of The Energy Returned On Invested
Authors: Camargo Federico Gabriel
Published: October 2022

This work was developed to present a conceptual and preliminary analysis of the concepts and criteria for estimating the Energy Return on Investment (EROI). In this work, methods based on monetary studies, Life Cycle Analysis (LCA) were discussed and a dynamical systems modeling was proposed. In this respect, we made a mathematical development, defining the state and auxiliary variables and the adjustment parameters necessary to study the problem. Some criteria and influencing factors were defined, in the medium and long term, the sustainability of the energy system and seek to incorporate them into relevant areas of discussion and education, encouraging their dissemination and reviews. It is sought to discuss the issues and considerations for a standardized methodology that allows comparisons and decision-making, in order to minimize environmental impact.
Thermo-mechanical study of the mixture of polylactic acid PLA obtained from potato starch with an aliphatic copolyester PBSA (polybutylene sucyanate adipate)
Authors: Amaya-Pinos Jorge
Published: October 2022

La conservación del medio ambiente ha llevado a investigar algunos polisacáridos con el objetivo de obtener bioplásticos que puedan ser dosificados con otros polímeros y tener mejores propiedades. En esta investigación, se realizó un estudio termo mecánico de dosificaciones entre el ácido poliláctico obtenido del almidón con otro polímero tipo poliéster alifático denominado polibutileno socianato adipato. Se realizaron diferentes mezclas y análisis tales como: análisis diferencial de barrido, termogravimétrico, espectroscopia infrarroja, índice de fluidez, dureza "SHORE" y un mecánico termodinámico; y en base a los resultados obtenidos, se determinó el tipo de procesamiento que puede sufrir la dosificación. Las dosis realizadas fueron desde 94,5% de PLA con 5% de PBSA hasta 20% de PLA con 79,5% de PBSA añadiendo 0,5% de crodamida como agente lubricante. Los resultados concluyeron que el bioplástico puede ser procesado por extrusión y termoformado, debido a que los valores del índice de fusión son relativamente bajos
Modelagem em uma concepção de Educação Matemática
Authors: Zontini Laynara dos Reis Santos , Burak Dionísio
Published: October 2022

Este artigo busca explicitar qual racionalidade sustenta e emerge das práticas que se fazem pelos pontos que constituem os fundamentos da Educação Matemática na concepção de Higginson (1980) e que se incorporam à Modelagem Matemática (MM) que segue esses mesmos pressupostos. Visualizamos a MM nessa perspectiva como uma das tendências metodológicas mais proeminentes para o ensino da Matemática, prioritariamente na Educação Básica. Para fundamentar a discussão, o texto traz subsídios da racionalidade técnica como sendo o principal modelo de formação de professores, pontuando e examinando algumas de suas principais características que podem explicar e trazer luz para a construção de uma nova racionalidade, a partir da Modelagem na concepção da Educação Matemática assumida para a formação de professores que atuam na Educação Básica. A partir disso, apresenta elementos que se mostram diferenciadores e promotores de uma nova racionalidade, baseada na visão sistêmica e na complexidade.
Palavras-chave: Educação matemática; modelagem matemática; complexidade.
Understanding the Impact of Belzutifan on Treatment Strategies for Patients with VHL
Authors: Arevalo Aileen , Patel Neal , Muraki Peter , Ohtake Shinji , Bratslavsky Gennady , Clark Chandra , Mann Joshua , Iliopoulos Othon , Jonasch Eric , Srinivasan Ramaprasad , Shuch Brian
Published: October 2022

Belzutifan was recently approved for the management of Von Hippel–Lindau disease (VHL). Given the morbidity of recurrent treatment, systemic therapy to reduce or eliminate the need for surgery has been long-awaited. Herein, we sought to gain insight about future utilization by surveying VHL  experts in the United States. A survey developed by members of the VHL Alliance (VHLA) Clinical Advisory Council was distributed to kidney cancer providers at VHLA and National Comprehensive Cancer Network (NCCN) centers. Surveys were administered on a secure web-based platform. A total of 60 respondents from 29 institutions participated. Urologists (50%) and medical oncologists (43%) represented the majority of participants. The majority (98%) of respondents anticipated that belzutifan’s approval would signifi-cantly change the current treatment landscape. Most reported that therapy should be continuous (76%). There was a difference in willingness to prescribe belzutifan by specialty (38% of urologists vs 91% of medical oncologists (P = 0.02). In individuals with renal tumors <3 cm, 36% would still recommend surveillance, while 36% would initiate belzutifan to prevent growth. In those with multifocal renal lesions and growth of a solitary tumor on belzutifan, 50% would proceed with only treatment of that site. In conclusion, VHL kidney cancer specialists anticipate a paradigm shift with the approval of belzutifan. Provider roles may change with movement away from surgical management. Opinions on treatment indications, such as when to initiate therapy and how to best salvage, vary widely and collaborative efforts among experts may assist in the development of clinical guidelines.
Métodos empleados para cuantificar la carga de trabajo en Enfermería en las unidades de cuidados intensivos: Una revisión de la literatura
Authors:   Universidad Cooperativa de Colombia, Cáceres Rivera Diana Isabel , Ruiz Sandoval Jessica Paola , Cristancho Zambrano Luisa Yaneth , Pulido Montes Maria Andreina , López Romero Luis Alberto
Published: October 2022

Introducción: La carga de trabajo de Enfermería en unidades de cuidado intensivo está relacionada con la eficiencia y calidad de la atención, sin embargo, no existen métodos para cuantificar las enfermeras necesarias por turno en UCI. Objetivo: Identificar las herramientas más utilizadas para medir la carga de trabajo de Enfermería en UCIs. Materiales y métodos: Se realizó una revisión de literatura tipo integradora, utilizando artículos originales en inglés, español o portugués, publicados entre 1991 hasta 2017 en las bases de datos: Science@direct, BVS, Socupus y Embase, empleando la estrategia de búsqueda: Nursing and workload and intensive critical or ICU unit and measure, se excluyeron artículos duplicados y/o desarrollados en UCIs de cuidado intermedio, la calidad de los artículos fue valorada usando la lista de chequeo Strobe. Resultados: Se incluyeron 36 artículos con un total de 19.036 pacientes; el 50% (n=18) empleo el NAS, 27.7%(n=10) utilizó una combinación de métodos como el NAS, NEMS, TISS-28 o el VACTE, el 13.8%(n=5) empleo el TISS-28, el 5.6%(n=2) empleo registro de cámaras de video y un 2.7%(n=1) empleo el NEMS para cuantificar el tiempo empleado por enfermería en el cuidado. Discusión: actualmente no existe un consenso sobre métodos de medición de carga de trabajo en enfermería, en este sentido, es necesario realizar más estudios de validación y comparación que permitan mejorar la gestión del cuidado de enfermería en UCI. Conclusión: La herramienta más utilizada para cuantificar la carga de trabajo en enfermería es el Nursing Activities Score (NAS), otras herramientas identificadas fueron: NEMS, TISS-28 y VACTE.
How mesenchymal stem cell conditioned media affect the HeLa cells on Wnt/beta-catenin signaling, Notch-1 signaling, and apoptosis?
Authors: DONMEZ Hanife Guler , SEVİM AKAN Handan
Published: October 2022

This study aims to investigate the influence of mesenchymal stem cells (MSCs) cell-conditioned media (MSCs-CM) on the Wnt/beta-catenin and Notch-1 signaling as well as the apoptosis in cervical cancer cells. Conditioned media of characterized MSCs were freshly collected and filtered before use. HeLa cells cultured standard conditions and treated with MSCs-CM 24, 48, 72 hours. Untreated cells serve as a control. Cell viability measured with MTT assay for all incubation periods. Immunocytochemical staining of beta-catenin, Notch-1 and cleaved caspase 3 were performed for each time-point. MTT cell viability, AO/PI, and immunocytochemical staining of cleaved caspase 3 results showed that through all incubation periods, there was no statistically significant difference between the MSCs-CM treated HeLa cells and the controls (p>0.05). Beta-catenin immunoreactivity was upregulated following treatment from 24 hours to 48 and 72 hours (p
An Efficient One-Pot Three-Component Synthesis of Novel Quinazoline-4-Carboxylic Acid and Its Ester and Amide Derivatives
Authors: GÖK Derviş
Published: October 2022

A series of novel quinazoline derivatives, which may be drug candidates, were synthesized, and their structures were characterized by IR, 1H NMR, 13C NMR and Q-TOF LC/MS spectrometry. First, 2-(4-chloro-phenyl)-quinazoline-4-carboxylic acid (2) was synthesized from a one-pot three-component condensation reaction of (2-amino-phenyl)-oxo-acetic acid sodium salt obtained from alkaline hydrolysis of isatin (indole-2,3-dione) with 4-chlorobenzaldehyde and ammonium acetate. The carboxylic acid compound 2 allowed the synthesis of the ester, acid chloride and amide derivatives. New quinazoline ester derivatives (3-6, 8) were synthesized by the reactions of compound 2 and various alcohols. Quinazoline amide derivatives (9-13) were then obtained from the reaction of different aliphatic and aromatic amines and 2-(4-chloro-phenyl)-quinazoline-4-carbonyl chloride (7) formed from the reaction of SOCl2 and compound 2.
THEORETICAL AND EXPERIMENTAL SUBSTANTIATION OF PREPARATION OF BIOACTIVE SUBSTANCES FOR PRODUCTION OF HIGHLY HOMOGENEOUS MIXTURES
Authors: Мakarynska A. , Iegorov B.
Published: October 2022

The paper supplies a theoretical base for the preparation of bioactive substances used to produce highly homogeneous mixtures. It presents theoretical and experimental data on the physical, technological, and chemical properties of vitamin preparations, carbonic and sulphuric acid salts of trace elements. The study has considered the interrelation, compatibility, and manifestations of the effects of synergism and antagonism, the one-sided and mutual influence of major and minor elements, vitamin preparations and minerals. It has been analysed how the composition of the premix, the filler, its properties affect the activity of bioactive substances. Besides, data are presented on how the moisture content, pH, temperature, and physical properties determine the degree of bioavailability of substances. It has been studied how big the particles are and how homogeneously bioactive substances are distributed when mixed with a premix filler. The size and shape of particles have been established to be essential factors when obtaining homogeneous mixtures. The characteristics of bioactive substances have been summarised, and their physical, technological, and chemical properties, the features of their preparation, and the technological stages of manufacturing premixes have been analysed. Based on this, classifications of bioactive substances have been developed for vitamin preparations and salts of trace elements. The step-by-step structure of the compound feed technological system that produces premixes has been described and compared with the earlier technologies. Based on the theoretical and experimental studies, reasons have been given for the classification of bioactive substances into three groups and for their proper preparation during premix production, depending on their bulk density, particle size, and percentage in the composition of premixes: 0.1–2.0 kg/t, 2.0–30.0 kg/t, 30.0–100.0, and more. It has been determined how particles of the premix components range in size (0.04–0.6 mm), and it has been established that the size of the filler particles should not exceed 0.8 mm. The problems of preparing bioactive substances in the premix production have been analysed, and it has been recommended how to solve them in order to obtain homogeneous mixtures, premixes, protein-vitamin supplements, and protein-mineral-vitamin supplements.
POTENTIAL OF USING SACCHAROMYCES BOULARDII TO PRODUCE FERMENTED MILK PRODUCTS
Authors: Khablenko A. , Danylenko S. , Yalovenko O. , Duhan O. , Potemskaia O.
Published: October 2022

The analysis of the literature allows us to characterise the potential of the new probiotic yeast strain S. boulardii. The paper describes the long period of formation of fundamental knowledge and introduction of some technological methods into the production of different fermented milks products. Besides the historical aspect, the microbiological diversity of fermented milks products is considered, and the technological differences in manufacturing them are shown. It is known that yoghurt is one of the most famous fermented milk products. This dairy product has been very popular for years due to its taste characteristics and ease of manufacture. With the accumulation of knowledge about probiotics and the yoghurt production technology, there has appeared a tendency to further enrichment of the product with certain probiotics, prebiotics, and minerals. Today, yoghurt manufacturing actively uses the method of enriching the finished product with probiotics. This allows creating a qualitatively new functional food product that not only has nutritional value for the consumer, but also produces a certain positive effect on intestinal microbes and thus on the consumer’s health. Bacteria are known to be the main probiotics, but the recent discovery of the probiotic properties of certain genera and species of yeast opens up new prospects of their use, both in the pharmaceutical industry and in creating functional foods. The recently discovered yeast strain S. boulardii, phylogenetically related to S. cerevisiae, has many therapeutic effects and significant advantages over bacterial probiotics, in particular, it is resistant to antibiotics. S. boulardii is a probiotic strain that can be used to enrich yoghurt. The physiological properties of the strain and therapeutic properties of the products of its metabolism along with the technological parameters of yoghurt processing make a combination of the probiotic and this beneficial fermented milk very promising. It has been determined that to produce enriched yoghurt, it is possible to use both a lyophilised culture of S. boulardii and a microencapsulated one. On analysing the economic aspect, especially the sale of yoghurts and the further tendency towards an increase in its consumption, we can say that the introduction of S. boulardii as an enrichment strain is a promising issue of current importance.