bluuebunny/crossref_metadata_2025 huggingface dataset:
NUDT22 promotes cancer growth through pyrimidine salvage and the TCA cycle
Authors: Walter Melanie , Mayr Florian , Hanna Bishoy Magdy Fekry , Cookson Victoria , Mortusewicz Oliver , Helleday Thomas , Herr Patrick
Published: March 2022

The NUDIX hydrolase NUDT22 converts UDP-glucose into glucose-1-phosphate and the pyrimidine nucleotide uridine monophosphate1. Glucose-1-phosphate is an important metabolite for energy and biomass production through glycolysis and the subsequent tricarboxylic acid (TCA) cycle and nucleotides required for DNA replication are produced through energetically expensive de novo or energy-efficient salvage pathways2. Here, we describe p53-regulated pyrimidine and glucose-1-phosphate salvage through NUDT22-dependent hydrolysis of UDP-glucose to maintain cancer cell growth and to prevent replication stress. We identified elevated NUDT22 expression in cancer tissues and reduced TCA intermediates and oncometabolites, growth retardation, S-phase delay, and slower DNA replication forks in NUDT22-deficient cancer cells. NUDT22 transcription is induced under starvation, oncogenic stress, and DNA damage directly through p53. Uridine supplementation rescues replication fork progression and alleviates replication stress. Conversely, NUDT22 deficiency sensitizes cells to de novo pyrimidine synthesis inhibition in vitro and reduces cancer growth in vivo. In conclusion, NUDT22 maintains pyrimidine supply and provides a substrate for the TCA cycle in cancer cells. Depletion of NUDT22 leads to genome instability and a reduction in TCA cycle metabolites, including oncometabolites such as 2-hydroxyglutarate and succinate. Targeting NUDT22 therefore has high potential for therapeutic applications in cancer therapy, simultaneously interfering with two essential survival pathways.
Collision tumor of invasive squamous cell carcinoma and adenoid cystic carcinoma in the oropharynx: a case report
Authors: Qian Senmi , Feng Meibao
Published: March 2022

Introduction: Primary collision tumors composed of two histologically distinct components are rare in the head and neck, its pathobiological features remain unclear. Case presentation: A man in his late 50s presented with paranesthesia pharynges and underwent upper endoscopy, followed by histopathological examination of biopsy specimens. He seems to have two tumors in the oropharynx with a size of 1.5*1.3cm, and an ulcer focus in the esophagus measuring about 1*0.8cm. Histopathological examination revealed a coexistence tumor of two components in the oropharynx, one was an adenocarcinoma with cribriform and solid growth pattern, with interstitial vitreous degeneration and central necrosis, the other was with a solid growth pattern, which was observed in both oropharynx and esophagus. The patient had a favorable outcome.Conclusion: Correct diagnosis can be challenging and is essential and beneficial for the prognosis of the patient.
Whole-genome sequence and genome annotation of Xanthomonas citri pv. punicae causing bacterial blight on pomegranate
Authors: Manjunatha N , Pokhare S.S , Sharma J , Patil P.G , Thorpe P , Agarrwal R , Chakranarayan M.G , Marathe R.A
Published: March 2022

The complete genome of Xanthomonas citri pv. punicae (Xcp-118), causal agent of bacterial blight of pomegranate, was sequenced using Illumina NextSeq500 platform. The 5.14 Mb genome has 64% GC content and contains 4371 genes with an average size of 980 bp; 4231 protein coding genes, 6 operons for rRNA and 58 tRNAs. Xcp-118 was found closest to Xanthomonas citri pv. punicae strain NCPPB 3563(CP030163) in phylogeny analysis. The complete genome sequence of Xcp-118 will provide novel insights into the pathogenesis of Xcp on pomegranate and may assist in finding a suitable blight resistant pomegranate variety.
Prevalence of cervical ribs and elongated transverse processes in Omani population: a computed tomography-based study
Authors: Subhi Marwa Al , Ajmi Eiman Al , Lawati Abdullah Al , Aswami Husain Al , Sirasanagandla Srinivasa Rao
Published: March 2022

IntroductionCervical ribs are the supernumerary ribs that usually arise from the seventh cervical vertebra. Ethnic and geographical variations in the prevalence of cervical ribs and elongated transverse processes have been reported. We aimed to study the prevalence of cervical ribs and elongated transverse processes in Omani subjects using computed tomography (CT). MethodsA total of 1165 consecutive patient CT scans of the cervical spine who had visited the tertiary care hospital from January 2016 to December 2020 were included in the study. The CT scans were screened for the presence of cervical ribs and elongated C7 transverse processes. The Chi-square test was used to determine the gender influence. Results Cervical ribs were identified in 0.94% of patients with a female dominance (p<0.05). The majority of the cervical ribs were unilateral (54%). The elongated C7 transverse process was identified in 18.45% of patients, with a male to female ratio of 1.36:1. The presence of an elongated C7 transverse process was strongly associated with gender (p< 0.001). ConclusionThe prevalence of cervical ribs in Omani subjects is close to that of generally accepted prevalence worldwide. However, the elongated C7 transverse process prevalence is comparatively high and close to the prevalence of the Saudi population.
Effects of agricultural pesticides on the susceptibility and fitness of malaria vectors in rural south-eastern Tanzania
Authors: Urio Naomi H , Pinda Polius G , Ngonzi Amos J , Muyaga Letus L , Msugupakulya Betwel J , Finda Marceline , Matanila Godfrey S , Mponzi Winifrida , Ngowo Halfan S , Kahamba Najat F , Nkya Theresia E , Okumu Fredros O.
Published: March 2022

Background
Agricultural pesticides may exert strong selection pressures on malaria vectors during the aquatic life stages and may contribute to resistance in adult mosquitoes. This could reduce the performance of key vector control interventions such as indoor-residual spraying and insecticide-treated nets. The aim of this study was to investigate effects of agrochemicals on susceptibility and fitness of the malaria vectors, Anopheles arabiensis across farming areas in Tanzania.
Methods
An exploratory mixed-methods study was conducted to assess pesticide use in four villages (V1-V4) in south-eastern Tanzania. An. arabiensis larvae were collected from agricultural fields in the same villages and their emergent adults examined for insecticide susceptibility, egg-laying, and wing lengths (as proxy for body size). These tests were repeated using two groups of laboratory-reared An. arabiensis, one of which was pre-exposed for 48hrs to sub-lethal aquatic doses of agricultural pesticides found in the villages.
Results
Farmers lacked awareness on the linkages between public health and agriculture sectors but were interested in being more informed. Agrochemicals usage was reported as extensive in V1, V2 & V3 but minimal in V4. Similarly, mosquitoes from V1-V3 but not V4 were resistant to pyrethroids, and either pirimiphos-methyl, bendiocarb or both. Adding the synergist, piperonyl butoxide, restored potency of the pyrethroids. Pre-exposure of laboratory-reared mosquitoes to pesticides during aquatic stages did not affect insecticide susceptibility in emergent adults of the same filial generation. There was also no effect on fecundity, except after pre-exposure to organophosphates, which were associated with fewer eggs and smaller mosquitoes. Wild mosquitoes were smaller than laboratory-reared ones but fecundity was similar.
Conclusions
Safeguarding the potential of insecticide-based interventions requires improved understanding of how agricultural pesticides influence important life-cycle processes and transmission potential of mosquito vectors. In this study, susceptibility of mosquitoes to public health insecticides was lower in villages reporting frequent use of pesticides compared to villages with little or no pesticide use. Variations in the fitness parameters, fecundity and wing length, marginally reflected the differences in exposure to agrochemicals, and should be investigated further. Pesticide use may exert additional life-cycle constraints on mosquito vectors, but this likely occurs after multi-generational exposures.
Endocuff-Assisted Colonoscopy Does Not increase the Sessile Serrated Lesion Detection Rate – A Randomized Controlled Trial
Authors: Ferreira Alexandre , Costa-Santos MP , Palmela Carolina , Gloria Luisa , Cravo Marilia , Canena Jorge , Dinis-Ribeiro Mário
Published: March 2022

Background
Colorectal cancer (CRC) is a leading cause of cancer-related death. Colonoscopy has been shown to decrease the incidence of CRC by facilitating the detection and resection of adenomas and serrated lesions. Endocuff vision (EV) has been shown to increase the detection of adenomas. The aim of this study was to compare the detection of sessile serrated lesions during colonoscopy with and without EV.
Methods
A total of 257 patients who underwent elective colonoscopy were prospectively enrolled. The patients were randomly allocated to one of two groups according to the use of EV (standard colonoscopy vs. colonoscopy with EV). We compared the rates of detection of serrated lesions (including hyperplastic lesions ≥ 10 mm) and adenomas.
Results
The number of serrated lesions per colonoscopy was not significantly higher in the EV group (0.233 vs 0.156, mean difference 0.076, p = 0.381). None of the secondary endpoints regarding the detection rate of adenomas (65.9% vs 66.4%; OR 0.977, 95% CI 0.583–1.638; p = 0.931) or sessile serrated lesions (12.4% vs 7.8%; OR 1.671; 95% CI 0.728–3.836; p = 0.226) were superior in the EV group. The differences were not significantly altered after adjusting for either the Boston Bowel Preparation Score (BBPS) or withdrawal time.
Conclusion
EV did not increase the rate of detection of serrated lesions or adenomas.
A Review of Recent Advances in Cytopathology for Diagnosis of Hepato-Biliary Lesions
Authors: Chandra Smita
Published: March 2022

Cytology has emerged as an important diagnostic modality for hepato-biliary lesions because of its minimally invasive, rapid turnaround time and cost-effective nature. This is especially important in diagnosis of neoplastic pathology of liver, gall bladder or bile duct where biopsy is difficult and delayed diagnosis may lead to complications or even mortality.  The advent of newer molecular diagnostic modalities like polymerase chain reaction (PCR), fluorescent in situ hybridization (FISH), immunochemistry or more recently circulating tumour cells and next generation sequencing (NGS) have not only led to precise diagnosis but are also helpful in targeted therapy and prognostication of tumour. Cytology which is a minimally invasive technique can be judiciously used for advanced molecular analysis for diagnosis and management of hepato-biliary lesions. Awareness regarding the use of cytological samples for molecular analysis in hepato- biliary lesions is essential so that mutational changes may be easily determined without undergoing any invasive technique in these deep-seated lesions. It is also necessary that guidelines on molecular cytology should be chalked out so that uniform reporting is followed with maintenance of high-quality standards.
Maintenance Feedback Mechanisms and Limiting Factors of Post-Occupancy Evaluation in Student Residents of Higher Education Institutions in Nigeria
Authors:   Department of Physical Planning and Works, Bells University of Technology, Ota, NIGERIA, Akuete Eseohe , Nduka David Obinna ,   Department of Building Technology, College of Science and Technology, Covenant University, Ota, NIGERIA, Ogundipe Kunle Elizah ,   CIDB Centre of Excellence, Faculty of Engineering and the Built Environment, University of Johannesburg, SOUTH AFRICA
Published: March 2022

A hostel facility’s effective functioning and performance contribute significantly to advancing knowledge and technologies for a sustainable future. Therefore, post-occupancy evaluation (POE) offers the basis for promoting construction projects’ future design and construction quality. The present study thereby examines the maintenance feedback mechanisms and limiting factors of POE to address future occupants’ satisfaction in selected hostels in Nigerian universities. A quantitative research design method was adopted where 340 questionnaire instruments were administered to the student occupants and facilities managers. The data obtained were subjected to descriptive statistics using a mean score, relative importance index and ranking. The research findings revealed that the maintenance feedback mechanisms utilised both by the student and facilities manager respondents have direct communication channels with the relevant stakeholders. The limiting factors of POE analysed showed that non-availability of information on building facilities, the persistence of maintenance challenges in building, lack of commitment from school management and insignificant improvement on the maintenance challenges were severe factors to be tackled in the studied hostels. Therefore, it is recommended that Nigerian universities’ regulating bodies conduct a building performance evaluation of existing hostel facilities in Nigerian universities and update the procedures guide and physical development manual for Nigeria’s university system.
Factors Influencing Governance Practices in Rural Development Projects: A Case Study of Rural Road Projects in Malaysia
Authors:   Faculty of Architecture, Planning and Surveying, Universiti Teknologi MARA, MALAYSIA, Abdul Latiff Abdul Muhaimin , Jaapar Aini ,   Faculty of Architecture, Planning and Surveying, Universiti Teknologi MARA, MALAYSIA, Mat Isa Che Maznah ,   School of Civil Engineering, College of Engineering, Universiti Teknologi MARA, MALAYSIA
Published: March 2022

Rural development projects are essential as a catalyst for balanced development between urban and rural areas, as well as tools for enhancing the living standard of the rural poor. This study focuses on the identification of factors that influence the governance practices in a rural road project in Malaysia. A single case study was conducted from the perspective of a stewardship theoretical lens on a rural road project in East Malaysia and multiple sources of evidence were used for data collection. The study discovered four main factors namely intrinsic motivation, altruistic empathy, effective leadership and shared vision that influence project governance practices in this project. Thus, this article contributes towards a better understanding of the interplay of these motivating factors, which drives public officials in different project actors for effective delivery in this project context. The findings of the study are limited to the utilisation of a single case study related to the rural road project and its contexts.
Modelling the effects of capital adequacy, credit losses, and efficiency ratio on return on assets and return on equity of banks during COVID-19 pandemic
Authors: Thonse Hawaldar Iqbal , Kumar Meher Bharat , Kumari Puja , Kumar Santosh
Published: March 2022

The study aims to determine the impact of Capital Adequacy Ratio, Credit Losses Ratio and Efficiency Ratio on the two significant profitability ratios, namely Return on Assets (ROA) and Return on Equity (ROE), during the pandemic. Panel Data Regression is used to model the effects of Capital Adequacy, Credit Losses and Efficiency Ratio on Return on Assets and Return on Equity of Indian banks. A suitable model has been developed by analyzing the results of the Hausman test and the p-values. It has been found that Capital Adequacy Ratio (CAR) with coefficient value of –0.664, CET1 with coefficient value of 1.83 and efficiency ratio with coefficient value of 1.825 have significantly affected the return on assets as their p-values are less than 0.05. However, the accepted relationship between CAR and ROA, efficiency ratio and ROA were inverse, but their coefficients were significant. The provision for credit losses (PCL) was not affecting the ROA significantly during the pandemic and hence was not considered while framing the model. Again, the dependent variable is the return on equity, except CAR. Other ratios, i.e., CET1, efficiency ratio, and PCL ratio have unacceptable correlations and are even non-significant as their p-values are less than 0.05.
ANÁLISE DA RELAÇÃO ENTRE A REMUNERAÇÃO DO TRABALHO E O NÍVEL DE INSTRUÇÃO: UMA ABORDAGEM ESTATÍSTICA.
Authors: Bastos Edson Vinicius Pontes , Carvalho Márcia da Silva , Macedo Marcelo Alvaro
Published: March 2022

Há uma concordância geral indicativa de que o nível de escolaridade é o principal fator que determina as discrepâncias de renda salarial entre indivíduos. Entretanto, não há um consenso a respeito do poder explicativo dos diferentes níveis de escolaridade e seu impacto no salário de um indivíduo. Desse modo, objetiva-se verificar se o poder explicativo da variável grau de instrução sobre a remuneração sofre acréscimo na proporção em que se aumentam os anos de estudo, indicando, portanto, alguns níveis onde outras variáveis influenciariam mais a remuneração do que o nível de escolaridade. Os resultados sugeriram que para os grupos de menor escolaridade o poder explicativo dos anos de estudo sobre a remuneração é estatisticamente significativo, porém é inferior ao poder explicativo sobre o grupo com maior nível de escolaridade, indicando que para os grupos de menor escolaridade existe outros fatores que impactam em maior grau a remuneração do indivíduo.
El Entorno Personal de Aprendizaje de profesores en formación en Educación Física. Estudio de preferencias durante la crisis sanitaria COVID-19 en el contexto chileno.
Authors: Cabrera Ramos Juan Francisco
Published: March 2022

El Entorno Personal de Aprendizaje (PLE) de los estudiantes de Pedagogía en Educación Física, es un componente esencial de la autonomía del aprendizaje durante la formación y en el rol que deberán desempeñar con sus estudiantes. En este sentido deben ser acompañados desde los programas formativos. En el contexto actual se desconoce las preferencias estudiantiles, lo que dificulta la creación de estrategias que permitan potenciar su autonomía en el aprendizaje con las TIC en el contexto de crisis sanitaria. Se describe, desde un enfoque cuantitativo, las preferencias de estudiantes de Pedagogía en Educación Física en el diseño de sus PLE. Se aplica encuesta a 57 estudiantes con un instrumento elaborado AD-HOC. Se hace un análisis descriptivo de datos cuantitativos y análisis de contenido en datos cualitativos. Se obtienen las preferencias de los estudiantes, donde priman la diversidad de uso de herramientas, la baja reflexión sobre sus PLE y carencias en la interacción centrada fundamentalmente en el entorno conocido, alto énfasis en el consumo de información y bajo énfasis en su producción y difusión. Se plantea la necesidad de acciones de formación específica asociadas a la competencia de aprendizaje autónomo que trascienda a un curso específico del mapa curricular.
Flipped Classroom para el desarrollo de competencias digitales en educación media
Authors: López Díaz Eyle Katerine , Lizcano Reyes Rafael Neftalí
Published: March 2022

La formación en competencias digitales ha ido adquiriendo una creciente relevancia en la sociedad del siglo XXI. Por tal motivo, generar espacios y experiencias de enseñanza – aprendizaje, apoyadas en las nuevas tecnologías con el propósito de lograr una transformación educativa, resulta imprescindible. El objetivo de esta investigación consiste en diseñar una propuesta metodológica desde el Flipped Classroom que permita el desarrollo de competencias digitales en los estudiantes del grado 10° de la IE Escuela Normal Superior Santa Teresita. Metodológicamente, este estudio presenta un enfoque cualitativo con un alcance descriptivo y un método de Investigación Basada en Diseño, utilizando la encuesta y entrevista semiestructurada como técnicas para la recolección de información. Para ello, cuenta con una muestra de 18 estudiantes. Los resultados obtenidos indican que con la implementación de la ruta metodológica basada en el modelo de Flipped Classroom (ClassFlip), los estudiantes pudieron desarrollar significativamente sus competencias digitales, expresando su satisfacción con la metodología utilizada y destacando los Recursos Educativos Digitales como material de apoyo en la construcción de sus conocimientos.
Editorial del número especial: Educación flexible en la era del conocimiento abierto
Authors: Agudelo Velásquez Olga Lucía , Salinas Jesús
Published: March 2022

El concepto de flexibilidad se encuentra, cada vez con más frecuencia, al hablar de la educación superior y de las respuestas que las instituciones educativas están dando a las demandas y presiones a que se ven sometidas. La flexibilidad es una de las más importantes cualidades de los nuevos entornos de aprendizaje. Se trata de atribuir al alumno la posibilidad de participar activamente en la toma de decisiones sobre el aprendizaje y supone una nueva concepción tanto en la organización administrativa, como de los materiales, los sistemas de comunicación, de mediación, y sobre todo, de las metodologías a implantar. Van den Brande (1993) hace referencia también a ello cuando demanda mayor flexibilidad mediante la adaptabilidad a una diversidad de necesidades de los alumnos, de modelos, escenarios de aprendizaje y combinación de medios.
I Simpósio Multidisciplinar de Geriatria e Gerontologia da PUC Minas
Authors: Faculdade de Medicina da PUC Minas
Published: March 2022

I Simpósio Multidisciplinar de Geriatria e Gerontologia da PUC Minas foi realizado gratuitamente, com o objetivo de realizar debates e reflexões acerca do envelhecimento saudável, a fisiologia do envelhecimento, o exame geriátrico e epidemiologia, além de discutir os impactos no cuidado com o idoso durante a pandemia do COVID-19. O evento foi realizado em ambiente online, possibilitando a união de conhecimentos de diversas áreas da saúde. Foi organizado pela Faculdade de Medicina da PUC Minas nos dias 28, 29 e 30 de outubro de 2021.
Transitional care: an omitted care unveiled by the pandemic
Authors: Ferreira Óscar Manuel Ramos , Lavareda Baixinho Cristina
Published: March 2022

In the international literature, there is a growing interest in omitted care in clinical practice in health, particularly in nursing, where a set of care essentially related to non-pharmacological interventions are omitted or delayed and undocumented. Errors by omission have translations in patient safety and impact their comfort, prognosis, hospitalization experience, functionality, and quality of life.
I Simpósio Online de Pediatria da UFMG - "Os desdobramentos da COVID-19 e do isolamento social na pediatria"
Authors: Liga de Pediatria da Universidade Federal de Minas Gerais
Published: March 2022

O I Simpósio Online de Pediatria da UFMG - "Os desdobramentos da COVID-19 e do isolamento social na pediatria" (SimPED) foi idealizado pelos coordenadores discentes e pela coordenação docente da Liga de Pediatria da Universidade Federal de Minas Gerais, a fim de abordar os novos desafios que os acadêmicos de medicina poderão encontrar nas consultas dos ambulatórios e centros de saúde, devido à pandemia do Sars-CoV-2, objetivando prepará-los para minimizar os impactos na vida das crianças e adolescentes. O SimPED constitui um evento gratuito que promoveu palestras com pediatras especialistas nos temas, bem como proporcionou a apresentação de pôsteres e temas livres, com a oportunidade de publicação dos melhores resumos na Revista Ciências em Saúde.
I Congresso Brasileiro de Cuidados ao Paciente Crítico
Authors: Associação dos Estudantes de Medicina do Brasil
Published: March 2022

A primeira edição do Congresso Brasileiro de Cuidados ao Paciente Crítico (ICBCPC), leva como lema a frase "Quando salvar vidas torna-se uma questão de tempo" e tem como objetivo principal propiciar um ambiente de disseminação de conhecimento de qualidade aos estudantes da saúde, sobre: Terapia Intensiva, Urgência e Emergência, Traumatologia e Cuidados Paliativos. Com uma abordagem multidisciplinar, buscamos abranger temáticas que circundam o cuidado ao paciente adulto e pediátrico em situação de fragilidade intra-hospitalar. De acordo com a portaria Nº2.338 de 3 de outubro de 2011, do Ministério da Saúde, “o paciente crítico/grave é aquele que se encontra em risco iminente de perder a vida ou função de órgão/sistema do corpo humano, bem como aquele em frágil condição clínica decorrente de trauma ou outras condições relacionadas a processos que requeiram cuidado imediato clínico, cirúrgico, gineco-obstétrico ou em saúde mental”. A nossa missão é levar aos futuros profissionais de saúde uma visão ampla e multidisciplinar sobre os cuidados necessários ao paciente crítico, contando com nomes renomados compondo nosso quadro científico, e promovendo o estímulo à escrita científica dos estudantes e profissionais interessados pelo tema, com a oportunidade de publicação nos anais do evento em revista indexada.
Efficacy, Benefits, and Harms of a Self-management App in a Swedish Trauma-Exposed Community Sample (PTSD Coach): Randomized Controlled Trial (Preprint)
Authors: Hensler Ida , Sveen Josefin , Cernvall Martin , Arnberg Filip K
Published: March 2022

BACKGROUND

Self-guided interventions may complement and overcome obstacles to in-person treatment options. The efficacy of app interventions targeting posttraumatic stress disorder (PTSD) is unclear, and results from previous studies on PTSD Coach—an app for managing trauma-related distress—are inconsistent.

OBJECTIVE

This study investigates whether access to the Swedish version of the PTSD Coach affects posttraumatic stress, depressive, and somatic symptoms. In addition, we aim to assess the perceived helpfulness, satisfaction, negative effects, response, and remission related to PTSD Coach.

METHODS

Adults who had experienced potentially traumatic events in the past 2 years were randomized (1:1) to have access to PTSD Coach (n=89) or be on the waitlist (n=90). We assessed clinical characteristics at baseline (semistructured interviews and self-rating scales) and after 3 months (self-rating scales). We analyzed the data in R software using linear mixed effects models, chi-square tests, and Fisher exact test.

RESULTS

Intention-to-treat analyses indicated that access to PTSD Coach decreased posttraumatic stress and depressive symptoms but not somatic symptoms. More participants who had access to PTSD Coach responded with clinically significant improvement and fewer instances of probable PTSD after 3 months compared with waitlist controls. Overall, participants found that PTSD Coach was slightly to moderately helpful and moderately satisfactory. Half of the intervention group (36/71, 51%) reported at least one negative reaction related to using PTSD Coach (eg, disappointment with the app or its results, arousal of stress, or distressing memories).

CONCLUSIONS

Using PTSD Coach may trigger symptoms among a few users; however, most of them perceived PTSD Coach as helpful and satisfactory. This study showed that having access to PTSD Coach helped improve psychological trauma-related symptoms. In addition, we have discussed implications for future research and clinical practice.

CLINICALTRIAL

ClinicalTrials.gov NCT04094922; https://clinicaltrials.gov/ct2/show/NCT04094922
Synthesizing Dimensions of Digital Maturity in Hospitals: Systematic Review (Preprint)
Authors: Duncan Rhona , Eden Rebekah , Woods Leanna , Wong Ides , Sullivan Clair
Published: March 2022

BACKGROUND

Digital health in hospital settings is viewed as a panacea for achieving the “quadruple aim” of health care, yet the outcomes have been largely inconclusive. To optimize digital health outcomes, a strategic approach is necessary, requiring digital maturity assessments. However, current approaches to assessing digital maturity have been largely insufficient, with uncertainty surrounding the dimensions to assess.

OBJECTIVE

The aim of this study was to identify the current dimensions used to assess the digital maturity of hospitals.

METHODS

A systematic literature review was conducted of peer-reviewed literature (published before December 2020) investigating maturity models used to assess the digital maturity of hospitals. A total of 29 relevant articles were retrieved, representing 27 distinct maturity models. The articles were inductively analyzed, and the maturity model dimensions were extracted and consolidated into a maturity model framework.

RESULTS

The consolidated maturity model framework consisted of 7 dimensions: strategy; information technology capability; interoperability; governance and management; patient-centered care; people, skills, and behavior; and data analytics. These 7 dimensions can be evaluated based on 24 respective indicators.

CONCLUSIONS

The maturity model framework developed for this study can be used to assess digital maturity and identify areas for improvement.
Photon-photon interactions in Rydberg-atom arrays
Authors: Zhang Lida , Walther Valentin , Mølmer Klaus , Pohl Thomas
Published: March 2022

We investigate the interaction of weak light fields with two-dimensional lattices of atoms with high lying atomic Rydberg states. This system features different interactions that act on disparate length scales, from zero-range defect scattering of atomic excitations and finite-range dipole exchange processes to long-range Rydberg-state interactions, which span the entire array and can block multiple Rydberg excitations. Analyzing their interplay, we identify conditions that yield a nonlinear quantum mirror which coherently splits incident fields into correlated photon-pairs in a single transverse mode, while transmitting single photons unaffected. In particular, we find strong anti-bunching of the transmitted light with equal-time pair correlations that decrease exponentially with an increasing range of the Rydberg blockade. Such strong photon-photon interactions in the absence of photon losses open up promising avenues for the generation and manipulation of quantum light, and the exploration of many-body phenomena with interacting photons.
Hybrid quantum-classical approach for coupled-cluster Green's function theory
Authors: Keen Trevor , Peng Bo , Kowalski Karol , Lougovski Pavel , Johnston Steven
Published: March 2022

The three key elements of a quantum simulation are state preparation, time evolution, and measurement. While the complexity scaling of time evolution and measurements are well known, many state preparation methods are strongly system-dependent and require prior knowledge of the system's eigenvalue spectrum. Here, we report on a quantum-classical implementation of the coupled-cluster Green's function (CCGF) method, which replaces explicit ground state preparation with the task of applying unitary operators to a simple product state. While our approach is broadly applicable to many models, we demonstrate it here for the Anderson impurity model (AIM). The method requires a number ofTgates that grows asO(N5)per time step to calculate the impurity Green's function in the time domain, whereNis the total number of energy levels in the AIM. Since the number ofTgates is analogous to the computational time complexity of a classical simulation, we achieve an order of magnitude improvement over a classical CCGF calculation of the same order, which requiresO(N6)computational resources per time step.
On the Issue of Free Movement of Financial Services and Capital in the Eurasian Economic Union
Authors: Zhiryaeva E. V. , Naumov V. N.
Published: March 2022

The article examines the macroeconomic indicators of the EAEU countries, used in quantitative methods for assessing financial integration, as well as a number of documents that form the common financial market (CFM) of the EAEU.

Aim. To identify the content of the concept of the EAEU CFM, having determined the elements of control of the movement of financial services and capital, to assess the possibilities of its formation, taking into account the achieved integration.

Task. To confirm the hypothesis that the insufficiently high existing level of financial integration in the EAEU is the reason why the mechanisms of the EAEU CFM cannot be sufficiently developed.

Methods. Correlation analysis, analysis and comparison of texts.

Results. Capital mobility is high in Russia and Kyrgyzstan. Converging consumption growth rates is a sign of equalizing financial risks. The countries differ in their exchange rate regimes, two of them maintain a double exchange rate, three have requirements for the repatriation of foreign exchange earnings. Capital flow measures are multidirectional. The CFM assumes the approximation of legislation in the field of financial services. Countries only commit to cross-border supply and consumption abroad for four subsectors, commercial presence is governed by national legislation, and the presence of natural persons is subject to migration regulations. The obligations to liberalize the services market taken to the WTO are not uniform, and the list of exemptions from obligations under the EAEU Treaty is more restrictive than obligations to the WTO. Most of the foreign exchange regulation measures are implemented in accordance with national laws. Investors from member states do not receive national treatment upon establishment.

Conclusion. The hypothesis is confirmed. The significance of the work for the theories of financial integration lies in the identification of the forms in which the CFM EAEU exists. The recommendations are intended for use in the work of the Eurasian Economic Commission.
AS DIMENSÕES DE GÊNERO NA PRODUÇÃO DA VIOLÊNCIA SEXUAL CONTRA CRIANÇAS
Authors: Baptista Spaziani Raquel
Published: March 2022

Este estudo tem como objetivo analisar a violência sexual contra crianças por meio dos estudos feministas e de gênero, discorrendo sobre as simplificações das análises individualizantes a respeito do tema. Isso porque considera-se que essa forma de violência é toda atravessada por questões de gênero, tanto pela construção de determinados modos de se exercer as masculinidades e as feminilidades como pelas relações desiguais de poder que esses investimentos sociais acarretam.
Pengembangan Buku Digital Berbasis RANDAI Terintegrasi Potensi Lokal pada Materi Keanekaragaman Hayati
Authors: Ulya Husnatul , Arsih Fitri , Alberida Heffi , Rahmi Yosi Laila
Published: March 2022

The RANDAI learning model is one of the learning models that can be used in biology learning. This model can be applied by using learning media that supports the implementation of the syntax of the learning model, one of which is in the form of a digital book. This study aims to produce an Integrated RANDAI-Based Digital Book on Local Potential on Biodiversity Materials for Class X SMA/MA. This research is a research and development research using the Plomp development model. The subjects in this study were 3 biology lecturers, 1 biology teacher and 31 students. The data obtained in this study are in the form of validity and practicality data. This study resulted in a very valid and practical RANDAI-Based Digital Book Based on Local Potential on Biodiversity Materials for Class X SMA/MA with a validity value of 92.53% meeting the very valid criteria and the practicality value by the teacher with a value of 91.91% meeting the very criteria. practicality and practicality scores by students with a value of 86.93% meet the practical criteria.
Key words: Digital Books, RANDAI Learning Model
 
Abstrak. Model pembelajaran RANDAI adalah salah satu model pembelajaran yang dapat digunakan dalam pembelajaran biologi. Model ini dapat diterapkan dengan menggunakan media pembelajaran yang mendukung pelaksanaan sintaks dari model pembelajaran tersebut, salah satunya dalam bentuk buku digital. Penelitian ini bertujuan untuk menghasilkan Buku Digital Berbasis RANDAI Terintegrasi Potensi Lokal pada Materi Keanekaragaman Hayati untuk Kelas X SMA/MA. Penelitian ini merupakan penelitian pengembangan (research and development) dengan menggunakan model pengembangan Plomp. Subjek dalam penelitian ini adalah 3 orang dosen Biologi, 1 orang guru biologi dan 31 orang peserta didik. Data yang didapatkan dalam penelitian ini berupa data validitas dan praktikalitas.  Penelitian ini menghasilkan Buku Digital Berbasis RANDAI Terintegrasi Potensi Lokal pada Materi Keanekaragaman Hayati untuk Kelas X SMA/MA yang sangat valid dan praktis dengan nilai validitas 92,53% memenuhi kriteria sangat valid dan nilai praktikalitas oleh guru dengan nilai 91,91% memenuhi kriteria sangat praktis dan nilai praktikalitas oleh peserta didik dengan nilai 86,93% memenuhi kriteria praktis.
Kata kunci: Buku Digital, Model Pembelajaran RANDAI
Response of Tuta absoluta to endophytic fungal entomopathogens in tomato.
Authors:   Lebanese University, Beirut, Lebanon, Ibrahim Ludmilla , Ezzeddine Nour ,   Faculty of Agricultural Engineering and Veterinary Medicine, Lebanese University, Beirut, Lebanon, Kamel Ibrahim Said ,   Faculty of Agricultural Engineering and Veterinary Medicine, Lebanese University, Beirut, Lebanon
Published: March 2022

Tuta absoluta is a leaf miner pest devastating tomato production. Use of broadspectrum pesticides to control this pest leads to the development of insecticide resistance, food contamination, poor health and environmental pollution. Recent knowledge of entomopathogenic fungi colonizing plants and, thus, antagonizing insect pests and plant diseases, sparked appreciable enthusiasm in using these capabilities. Therefore, this study aimed to assess the abilities of entomopathogens to endophytically colonize tomato plants, and to determine the ability of fungal species to modulate the behavior of T. absoluta. The two inoculation procedures (seed treatment and direct injection) allowed Metarhizium anisopliae and Beauveria bassiana strains to endophytically colonize tomato plants and thus have influenced the preference of T. absoluta oviposition. In Beauveria- and Metarhizium-colonized leaf mesophyll, damage by T. absoluta was significantly lower compared to control plants. This was attributed to the reduced number of eggs (7-8 plant-1 ) on fungus-colonized plants as opposed to 19 plant-1 on control plants in seed-treated assay. Reduced size of mines in Beauveria-injected plants has also contributed to the decrease in damage area by leaf miner larvae. The outcomes of this study suggest that seed inoculation is an effective method to be adopted by plant nurseries for commercial production of pre-colonised with entomopathogenic endophytes tomato plantlets.
Arabic and Latin keyboard Choice in Lebanese Students’ Discussions on WhatsApp.
Authors:   Saint Joseph University: Université Saint-Joseph, Beirut, Lebanon, Halawi Ayman , Messarra Nasri ,   Saint Joseph University: Université Saint-Joseph, Beirut, Lebanon, Bou Nader Raymond ,   Saint Joseph University: Université Saint-Joseph, Beirut, Lebanon
Published: March 2022

Written discourse in WhatsApp discussions has been addressed in several articles in Computer-Mediated Communication (CMC). The aim of this study is to determine Lebanese universities students’ choice between Arabic and Latin keyboards while typing their online messages in WhatsApp groups and try to determine variables that affect their keyboards’ choices. We joined 33 WhatsApp discussion groups from 7 major Lebanese universities and gathered 227,059 messages written by 1,112 multilingual students. The results showed that even though Arabic keyboard is not very popular amongst some Lebanese universities’ students, it is still present in WhatsApp groups’ discussions of students especially at some faculties of the official Lebanese University where courses are taught in Arabic language. The results showed also that Arabic is widely typed in Arabizi using a Latin keyboard. This seems to be the case in the majority of universities that took part in the study. In addition, students at universities with high tuition fees and those who are having their curriculum in foreign languages use Latin keyboard more than students at some faculties of the public university.
Uso de antibióticos y resistencia antimicrobiana en la unidad de cuidado intensivo neonatal
Authors: García Henao Juan Pablo , García Ríos Juan Manuel , Naranjo Arango Yonatan Andrés , Grajales Rojas Julián , Vinasco Sánchez Luis Gabriel
Published: March 2022

La sepsis neonatal constituye una de las principales causas de mortalidad neonatal en los países en desarrollo. Los neonatos, en particular los prematuros, tienen un mayor riesgo de infecciones bacterianas, por lo que el manejo con antibióticos constituye la terapia más frecuente en la Unidad de Cuidado Intensivo Neonatal (UCIN), estimándose en hasta un 70%. La presentación clínica de la sepsis neonatal es inespecífica en muchas ocasiones, lo que hace que la antibioticoterapia empírica se inicie tempranamente para evitar consecuencias deletéreas para los pacientes; su inespecificidad la caracteriza como un reto diagnóstico, por lo que diferentes autores han diseñado estrategias para determinar neonatos candidatos a terapia antimicrobiana.
La microbiología permanece en contacto estrecho con la clínica ya que conocer los gérmenes frecuentemente asociados a la sepsis neonatal ayuda a determinar el espectro antibiótico a usar. De igual forma, el conocimiento de la farmacología antibiótica es clave puesto que el tratamiento antibiótico no es inocuo y puede asociarse a aumento de morbilidad o mortalidad. El tiempo de evolución y los factores de riesgo maternos están asociados a los gérmenes responsables esperados, ya descritos por  múltiples estudios descriptivos a nivel mundial.
El uso indiscriminado de antibióticos de amplio espectro para el manejo de infecciones en los recién nacidos ha generado un aumento en la resistencia antibiótica, lo que a su vez lleva a tasas más altas de fallo terapéutico con el uso de las terapias antibióticas empíricas. A razón de lo anterior, los Programas de Vigilancia de Uso de Antibióticos juegan un papel determinante para monitorear el cambio en la resistencia a nivel local para ajustar y homogeneizar la práctica médica que logre regular el uso de antibióticos y mitigar la emergente resistencia bacteriana.
Fiebre de malta: reporte de caso
Authors: Castillo López Daniela Rocío , Vargas Rodríguez Ledmar Jovanny , Rozo Ortiz Edwar Jassir , Barón Barón Javier Orlando
Published: March 2022

Introducción: La fiebre de malta (brucelosis) es una infección zoonótica producida por cocobacilos gramnegativos, intracelulares facultativos, los cuales se transmiten por el consumo de productos animales no pasteurizados infectados, el contacto de la piel o las membranas mucosas con tejido animal infectado, fluidos animales infectados e inhalación de partículas aerosolizadas infectadas.

Caso: Hombre de 34 años residente en zona rural, quien se dedicaba a la ganadería, ingreso a urgencias por presentar cuadro clínico de 15 días de evolución consistente en picos febriles no cuantificados asociados a escalofríos, astenia, adinamia y mialgias. Mediante la correlación clínico-patológica se llegó al diagnóstico de infección por Brucella Abortus. Conclusión: Esta patología es más frecuente en varones adultos. Dentro del cuadro clínico, Los estudios de serológicos (anticuerpos, aglutinación y ensayo inmunocromatográfico) tienen la mayor sensibilidad y especificidad diagnostica. El tratamiento se da con medicamentos que actúen en entornos intracelulares ácidos (tetraciclinas, aminoglucosidos, fluoroquinolonas), esto con el fin de controlar la enfermedad, prevenir las complicaciones y evitar las recaídas.
Fístula colovesical secundaria a diverticulitis complicada: tratamiento laparoscópico. Reporte de caso
Authors: Gómez Pineda Alfonso León , Domínguez Alvarado Gonzalo , Peña Figueroa Paula Andrea , Orozco Castillo Maria Fernanda , López Gómez Luis Ernesto
Published: March 2022

Introducción: La fístula colovesical es la unión entre la vejiga y el intestino grueso, se presenta en el 2% de los pacientes con enfermedad diverticular del colon, genera síntomas como neumaturia y fecaluria, asociados a infecciones urinarias recurrentes. Los pacientes se diagnostican mediante estudios imagenológicos y su tratamiento generalmente es quirúrgico. 

Objetivo: Reportar el caso   de  tratamiento laparoscópico  de paciente con  fístula colovesical secundaria a diverticulitis complicada.

Caso clínico: Se presenta el caso de un paciente masculino de 69 años, con antecedente de enfermedad diverticular, cursando con infección de vías urinarias recurrentes, fecaluria y neumaturia. La cistoscopia no mostró trayecto fistuloso y la tomografía abdominopélvica mostró hallazgos inflamatorios y fístula colovesical asociada a diverticulitis complicada. Durante procedimiento laparoscópico se encuentra absceso pericólico sin evidencia del trayecto fistuloso, se realizó drenaje, sutura del colon e interposición del epiplón, sin resección intestinal. Paciente con adecuada evolución postoperatoria con egreso al sexto día. El objetivo del tratamiento quirúrgico se centra en el control de complicaciones generadas por los divertículos, en este caso, la fístula colovesical.

Conclusiones: El procedimiento laparoscópico es de mínima invasión, no presenta la morbilidad que implica una resección de colon o una colostomía y  se asocia con una recuperación funcional más rápida.
COVID-19 in patients with seizures: considerations for therapeutic management and potential drug-drug interactions
Authors: Jain Shreshta , Potschka Heidrun , Chandra P Prarthana , Tripathi Manjari , Vohora Divya
Published: March 2022

In regard to the global pandemic of COVID-19, it seems that persons with
epilepsy (PWE) are not more vulnerable to get infected by SARS-CoV-2,
nor are they more susceptible to a critical course of the disease.
However, management of acute seizures in patients with COVID-19 as well
as management of PWE and COVID-19 needs to consider potential drug-drug
interactions between antiseizure drugs and candidate drugs currently
assessed as therapeutic options for COVID-19. Repurposing of several
licensed and investigational drugs is discussed for therapeutic
management of COVID-19. While for none of these approaches, efficacy and
tolerability has been confirmed yet in sufficiently powered and
controlled clinical studies, testing is ongoing with multiple clinical
trials worldwide. Here, we have summarized the possible mechanisms of
action of drugs currently considered as potential therapeutic options
for COVID-19 management along with possible and confirmed drug-drug
interactions that should be considered for a combination of antiseizure
drugs and COVID-19 candidate drugs.
Fourier spectral high-order time-stepping method for numerical simulation of the multi-dimensional Allen-Cahn equations
Authors: Bhatt Harish , Joshi J
Published: March 2022

This paper will introduce the Fourier spectral method combined with the
strongly stable exponential time difference method as an attractive and
easy-to-implement alternative for the integration of multi-dimensional
Allen-Cahn equations with no-flux boundary conditions. The main
advantages of the proposed method are that it utilizes the discrete fast
Fourier transform which ensures efficiency, allows an extension to two
and three spatial dimensions in a similar fashion as one-dimensional
problem, and deal with various boundary conditions. Several numerical
experiments are carried out on multi-dimensional Allen-Cahn equations to
demonstrate the fourth-order temporal accuracy and stability of the
method. The numerical results showed that the proposed method is
fourth-order accurate in the time direction and is able to satisfy the
discrete energy law.
On the solvability of time conformable fractional equation set on singular domain of R^{N+1}
Authors: belkacem chaouchi , Benbachir Maamar , Kostic Marko
Published: March 2022

In this paper, we investigate the solvability of time conformable
fractional equation set in a singular cylindrical domain in
R^{N+1}. Some regularity results are obtained for the classical
solutions by using the Dunford operational calculus