bluuebunny/crossref_metadata_2025 huggingface dataset:
“Coordination caps” of graded electron-donor capacity
Authors: Stritt Anika , Ünal E. Alper , Irran Elisabeth , Grohmann Andreas
Published: January 2025

An efficient synthesis of the novel {6-[1,1-di(pyridin-2-yl)ethyl]pyridine-2-yl}2-methyl-1,3-propanediamine (2) is reported, as well as a reliable large-scale synthesis (of the order of 100 g) of previously known 2,2’-[1-(6-chloropyridin-2-yl)ethane-1,1-diyl]dipyridine (4); the latter is the starting material for the preparation of the former, as well as a multitude of other polypodal polyamine/polyimine ligands. Both materials, as well as the intermediates in their multi-step syntheses, have been fully characterised. Ligand 2, in conjunction with ligands 2,2’-(pyridine-2,6-diyl)bis(2-methylpropane-1,3-diamine) (1) and 2,6-bis(1,1-di(pyridin-2-yl)ethyl)pyridine (3), establishes a series of tetrapodal pentadentate N5 ligands L of like scaffold, and thus coordination geometry, but graded primary amine/imine donor atom ratios. The iron(II) complexes [Fe(L)NCCH3](OTf)2 (L = 1: A; L = 2: B; L = 3: C; OTf = triflate) have been prepared and fully characterised, including X-ray single-crystal structure analyses. The metal-centred one-electron oxidation/reduction potential (FeII/FeIII) depends sensitively on the electron donor capacity of the capping ligand used, as demonstrated by cyclic voltammetry. Whereas the acetonitrile ligand in A and C is readily exchanged for a methanol ligand in methanol solution, the resulting complexes showing variable-temperature spin crossover (SCO) in solution, B has been found to be inert to this type of ligand exchange.
French marigold (Tagetes patula) flavonoid extract-based priming ameliorates initial drought stress on Oryza sativa var indica, cultivar Satabdi (IET4786): a sustainable approach to avoid initial drought stress
Authors: Saha Arunima , Kumar Suraj , Dey Sanjukta , Bhattacharyya Chiranjib , Sahu Ranabir , Ashraf Gouhar Jahan , Bhattacharyya Somnath , Das Pritam , Bandyopadhyay Subhendu , Dewanjee Saikat , Gangopadhyay Moumita
Published: January 2025

Drought stress remains a serious concern in Oryza sativa L. var indica, cultivar Satabdi (IET4786) production, particularly during the earliest growth phases, ultimately affecting yield due to the recent trend of delayed rain arrival in West Bengal, India. This study aimed to develop a cost-effective strategy to improve the drought tolerance capacity of rice seedlings by priming the seeds with flavonoid-enriched extract (FEE) of French marigold (Tagetes patula) petals to withstand the initial drought milieu. The morpho-physiological and biochemical responses of rice seedlings were evaluated to perceive the priming efficacy in alleviating water stress-induced untoward effects. The findings revealed that mechanical priming of the IET4786 seeds with FEE (50 mg/mL for 30 min) significantly improved seedling survival against initial drought stress for 14 days. After 24 h of recovery from drought stress, the primed seed-derived seedlings exhibited significantly improved morphological, physiological, biochemical, and redox parameters compared to the seedlings derived from unprimed seeds under net house conditions. In search of mechanistic insights, seed priming significantly increased proline content by endorsing Δ1-pyrroline-5-carboxylate synthetase activities, endorsed methylglyoxal clearance homeostasis by improving glyoxalase I and II activities through restoring glutathione (GSH) level, and enhanced polyamine accumulation in the leaves of seedlings to endure drought stress.
The Impact of Corporate Sustainability Reporting Regulation on Business and Financial Performances of Companies in Bosnia and Herzegovina
Authors: Serdar Raković Tajana
Published: January 2025

Given the global trends and initiatives for environmental preservation and transition to sustainable development, the corporate sector has been facing a turning point in corporate reporting. The sustainable business requirements also initiate a series of new challenges in the financial and accounting sector related to the development of accounting solutions for integrating sustainability issues into financial statements. In addressing the green transition problems, the EU has adopted the Corporate Sustainability Reporting Directive (CSRD), which modernizes and strengthens the rules concerning the social and environmental information companies must report in their financial statements. The research was carried out by conducting a survey among the population interested in corporate finances, especially accountants. The main goal of the research is to analyse the impact of sustainable reporting regulation on the corporate sector’s financial performance and companies’ operations in Bosnia and Herzegovina. The results show that EU CSRD will significantly impact doing business and performances of companies and that the companies that adapt to new sustainability reporting regulations will have higher chances of obtaining positive financial performances and adequately addressing the increasing demand of stakeholders for more comprehensive business reporting.
Optimizing Stereolithography Printing Parameters for Enhanced Microfluidic Chip Quality
Authors: El Biyari Nidal , Zekriti Mohssin
Published: January 2025

In the pursuit of innovative biosensing technologies for critical applications such as early breast cancer detection, the development of efficient and portable devices is crucial. This work describes a unique stereolithography (SLA)-based three-dimensional–printed microfluidic device intended particularly for optofluidic biosensing with just microliter quantities of blood, similar to diabetes monitoring devices. Unlike typical cumbersome lab equipment such as the Biacore machine, which needs large blood sample volumes and laboratory processing, microfluidic technology allows for patient-operated, at-home testing, decreasing the requirement for hospital visits. The main contribution of this study is to optimize the SLA printing parameters, namely the exposure duration, in order to improve the microfluidic chip’s transparency and channel quality. This improvement allows for the exact immobilization of biorecognition components within the channels, resulting in sensitive and efficient biomarker detection. By extending the exposure duration, we considerably increase the structural integrity and optical clarity of the microfluidic channels, which are critical for successful biosignal transduction in labeled sensing applications. This development not only leads to a cheaper cost and faster manufacturing compared with conventional technologies but also offers increased performance in real bio-sensing applications. Thus, our work represents a big step forward in the development of accessible, efficient, and compact devices for early-stage illness diagnosis, outperforming existing lab-based diagnostics.
S’unir pour accompagner les élèves dans le développement des compétences en lecture à l’ère du numérique
Authors: Legault France , Beaudry Marie-Christine , Carignan Isabelle
Published: January 2025

L’utilisation du numérique en classe amène les élèves à lire sur différents supports. L’enseignement de stratégies de lecture adaptées apparait donc important pour pouvoir outiller les élèves. Au secondaire, une difficulté supplémentaire s’impose : le transfert des apprentissages entre les disciplines. Ces enseignements doivent également être accessibles aux parents afin que ces derniers puissent soutenir leur enfant. Actuellement, le personnel enseignant a peu de ressources pour soutenir le développement de ces stratégies de lecture (Legault et al., 2021). Ainsi, la mise en place de structures de communication et d’outils favorisant la littératie, autant à l’école qu’à la maison, semble être une avenue prometteuse.
Exploring the Role of Location-Based Games in Managing Tourist Destinations Under Climate Change Challenges: A Gap Analysis Review
Authors: Mansourihanis Omid , Hemmati Moein , Afshar Sepehr Vaez , Eshaghi Sarvin , Varinlioğlu Güzden
Published: January 2025

Global climate disruptions pose escalating threats to tourism networks, necessitating innovative resilience solutions tailored for regional interdependencies. This review examines research on location-based games for enhancing climate resilience across interconnected tourism economies. Analyzing 75 studies, strengths and limitations are delineated. While confirming augmented reality, virtual reality, and geo-tagging versatility for promotion, analysis, and experience enhancement, findings reveal gaps in leveraging these technologies for systemic coordination, participatory governance, embodied vulnerability assessment, and social learning. Immersive climate visualizations, policy simulations, and multiplayer interfaces emerge as frontiers enabling collaborative adaptation. The top priorities are (1) integrating localized climate projections with human perceptions through interactive visualizations to create tangible threats, (2) designing policy simulations for participatory governance of resilience investments across sectors, (3) developing embodied social learning vulnerability assessments highlighting differential exposures, and (4) designing multiplayer games to facilitate the co-creation of equitable, robust adaptation strategies by communities. Targeted research advancing location-based platforms to link science, policy, and community priorities is essential for tourism networks to navigate intensifying climate disruptions collaboratively. This review thus delineates critical next steps in utilizing geo-technologies’ participatory, experiential promise to inform and connect stakeholders in steering tourism toward resilient pathways.
Stress-reducing strategies and interventions for gynecology & obstetrics residents: a narrative review
Authors: Mirzaei Alireza , Jamshidian Sepideh , Haghani Fariba
Published: January 2025

As a result of the high levels of stress and burnout in obstetrics and gynecology residents and its negative impact on their personal and professional functioning, and ultimately on the quality of patient care, attention to the health and well-being of this group of medical students has increased. Numerous strategies have been used to help reduce or cope with stress. This study aimed at identifying effective educational strategies to reduce stress in obstetrics and gynecology residents. For this narrative review, we searched ScienceDirect, Emerald, PubMed, Web of Science, and Google Scholar databases for relevant information sources published from 2013 through 2022. This study retrieved 15 stress reduction strategies for obstetrics and gynecology residents from 9 articles that met the inclusion criteria. We established that strategies such as stress management training, resilience training, emotional intelligence training, mindfulness practices, team bonding sessions, feedback and reflection sessions, and access to confidential and free psychotherapy and mentoring programs were effective in improving the well-being of residents in this medical field.
Driving Safer: A Look at How Men and Women Use Advanced Driver Assistance Systems
Authors: Afshari Abolfazl , Azadnia Alireza , Ghasemzadeh Mehdi , Yazdani Shiva , Razzaghi Alireza , Daneshi Salman , Hushmandi Kiavash
Published: January 2025

Objective — This study investigates the nuanced landscape of gender-specific patterns in utilization of Advanced Driver Assistance Systems (ADAS), aiming to contribute insights to enhance road safety. Methods — Leveraging data from diverse sources, including Scopus, Web of Science, and Google Scholar, the method employed involves a meticulous examination of studies exploring gender differences in driving behaviors and ADAS adoption. Key factors influencing these differences, were analyzed including age, experience, and attitudes toward technology. Cultural and societal influences on gender-specific driving behaviors are explored, shedding light on the intricate interplay of perceptions and expectations. Results — The review identifies challenges in ADAS adoption, including limited awareness, misconceptions, and resistance to change. Opportunities for improvement are then outlined, encompassing comprehensive user training, clear communication of ADAS features, customizable settings, and incentives for ADAS-equipped vehicles. This study showed that men tend towards aggressive driving behaviors, while women prioritize caution and adherence to traffic rules. Women propensity for safety-oriented features such as lane-keeping assistance, while men display a preference for convenience-focused features such as adaptive cruise control and parking assistance. Conclusion — By addressing challenges and embracing opportunities, the study advocates for a future where ADAS technologies contribute significantly to safer and more equitable roadways for all drivers.
Evaluation of long-term symptoms and recurrence of bowel nodules after resection of deep bowel endometriosis: A retrospective cohort study
Authors: Hosseini Reihaneh , Asgari Zahra , Valian Zahra , Hajilo Nasrin , Aliabadi Nahid Rezaei , Ebadijamkhane Aghdas
Published: January 2025

Background — Bowel endometriosis nodules (BEN) result from an abnormal growth of endometrial fragments located on intestine causing visceral pain, scars, and organ adhesions. Deep endometriosis operation (DEO) is performed in case of deep infiltrating endometriosis (DIE) as a routine procedure for BEN excision. In this retrospective cohort study, the authors aimed to investigate the long-term symptoms and the recurrence rate of BEN in DIE women. Methods — The cases were pooled into two groups based on presence of surgery of bowel endometriosis (SBE, n=32) and absence of surgery of bowel endometriosis (no-SBE, n=44). Using inclusion and exclusion criteria, we selected 76 DIE women from Arash Women’s Hospital (Tehran, Iran). General patient information and surgery-related data were extracted from medical histories of DIE patients (2018-2021). Two years of postoperative follow-up were part of our study, and endometriosis symptoms, pelvic pain, and BEN recurrence rate were assessed. Data were analyzed using SPSS (v.19), and statistical significance was assumed at p<0.05. Results — No statistically significant (p=0.54) differences were detected between two groups (SBE and no-SBE) regarding pain recurrence. In SBE group, 28.1% of DIE women exhibited BEN recurrence, while this proportion was 9.4% in no-SBE women that had larger size of BEN. Changes in BEN sizes were not significant (p=0.6) as compared with pelvic pain. Conclusion — No significant differences were found between long-term symptoms and recurrence of BEN in women with DIE after SBE and without SBE. Excision of BEN during surgical procedures is not recommended clinically.
Arterial hypertension and COVID-19 in Arctic rotating shift work: the impact of chronostructure disruptions on circadian blood pressure rhythm in relation to echocardiographic parameters
Authors: Shurkevich Nina P. , Vetoshkin Aleksandr S. , Kareva Maria A. , Gubin Denis G.
Published: January 2025

This study investigated the effects of chronostructure disruptions on circadian blood pressure (BP) rhythms and their association with echocardiographic parameters in men with arterial hypertension (AH) who contracted COVID-19 while engaged in rotating shift work in the Arctic. Methods – A random sample of 166 men with arterial hypertension (AH) was selected from the medical records database of patients treated at the hospital of the Medical Unit of Gazprom Dobycha Yamburg LLC in Yamburg (Nadymsky District, Russia, 68° 21’ 40” N) between June 2020 and March 2021. Randomization was achieved using a random number method. These patients underwent echocardiography (ECHO) and 24-hour ambulatory blood pressure monitoring (ABPM) before the COVID-19 pandemic (November 2019 to March 2020) and again in 2021. The group was then divided into those who had contracted COVID-19 (n=94) and those who had not (n=72). ABPM was performed using a BPLab v.3.2 device (BPlab, Russia). Chronobiological analysis was performed to identify the main hypertensive BP chronotypes (CT) based on the P. Cugini classification: “MESOR AH”, characterized by a 24-hour rhythm period (T); and “Aperiodic AH”, characterized by a predominance of oscillations with periods (T) of 4.0, 4.8, 6.0, and 8.0 hours within the circadian rhythm. Echocardiography (ECHO) was performed using a Philips CX 50 scanner (Netherlands). Results – Logistic regression analysis showed that the presence of the “Aperiodic AH” chronotype was associated with a threefold increase in the odds of contracting COVID-19, while a 1 g/m² increase in the left ventricular mass index (LVMI) increased these odds by a factor of 1.02. One year post-COVID-19, individuals with “Aperiodic AH”, in contrast to those with “MESOR AH”, exhibited increases in right atrial and inferior vena cava diameters, systolic pulmonary artery pressure, tricuspid regurgitation velocity, stroke volume, and cardiac output, as well as a more pronounced increase in left ventricular mass and LVMI. Associations were observed between structural alterations in the heart and parameters that reflect disruptions in the circadian BP rhythm. Conclusion — Within the context of Arctic rotating shift work, men with arterial hypertension (AH) exhibiting a disrupted chronostructure of the circadian BP rhythm, characterized by a predominance of irregular, short-term oscillations, and structural alterations in the heart, are more susceptible to COVID-19. This increased susceptibility is associated with more pronounced alterations in echocardiographic parameters following the infection.
Pharmacokinetic study and phytochemical analysis of beetroot powder as an initial stage of the development of an NO-boosting formulation as a food supplement with cardioprotective properties and potential donor of nitric oxide
Authors: Bogdanova Natalya L. , Gumanova Nadezhda G. , Kiselev Anton R. , Drapkina Oxana M.
Published: January 2025

Background — Production of nitric oxide (NO) can be modulated endogenously by enzymatic synthesis of NO from L-arginine within the body or exogenously via diet. Bioactive NO levels can be influenced by adding various foods rich in nitrite and nitrate (NOx). Objective — The aim of the present study was to investigate pharmacokinetics and perform phytochemical analysis of NOx as an active component in finely dispersed powder of a dried beetroot formulation to assess the shelf life that corresponds to minimal losses in the NOx contents while preserving optimal pharmacokinetic characteristics. Results — The beetroot powder was manufactured by infrared dehydration of beetroot. The NOx content per dry weight of the beetroot powder was 25.2 g/kg (25,200 mg/kg), which was 10-fold higher than NOx content per kg of untreated beetroot. The data indicated that powdered beetroot can be stored at room temperature for at least a year without detectable loss in nitrate content. Tmax for NOx was 30 min after loading, and Cmax for NOx was 209 μM or 52% of the loading dose of 400 mg contained in 11 g of dry beetroot powder. The half-life of NOx delivered to the blood plasma (T1/2) was 10 h. Conclusion — The recommended daily dose of the beetroot powder is 16 g, which is equivalent to 400 mg of NOx. Considering pharmacokinetic characteristics, the data indicated that the beetroot formulation is able to boost NO levels after being added to the diet and may be used to normalize the level of NOx in the blood and tissues to compensate for pathological changes in synthesis or bioavailability of endogenous NO.
Comparative analysis of the flavonoid characteristics of Camellia oleifera flowers in different plantations in Guizhou, China
Authors: Hao Yurui , He Guandi , Yang Sanwei , Yang Zhannan , Quan Wenxuan
Published: January 2025

Camellia oleifera is a multipurpose plant resource that contains flavonoids. To explore the differences in the characteristics and metabolic pathways of flavonoids in Camellia oleifera flowers from different plantations, this study compared the differences in the water content, total ash content, ethanol soluble extract, and total flavonoid content of samples from six plantations. Widely targeted flavonoid metabolomics techniques were used to analyze the metabolic characteristics of the different plantations. There were significant differences in total flavonoid content among the different plantations (P < 0.05), with Tianzhu County having the highest total flavonoid content (average value of 13.60 mg/g) and Liping County having the lowest total flavonoid content (average value of 2.39 mg/g). UPLC-MS/MS revealed a total of 13 categories and 758 flavonoid metabolites, among which flavonols, flavonoids, and tannins were the main flavonoid compounds. A total of 266 differentially abundant metabolites were screened via the OPLS-DA model, and KEGG enrichment analysis revealed that the enrichment pathways of differentially abundant metabolites between different plantations were related mainly to the biosynthesis of secondary metabolites, flavonoid biosynthesis, metabolic pathways, etc. This study provides a theoretical reference for the subsequent development and utilization of Camellia oleifera resources, especially in the utilization of Camellia oleifera flower resources.
Performance of Cunninghamia lanceolata / Uncaria composite particleboard
Authors: Zhang Qiaoyan , Wu Longxu , Liao Huagang , Yang Qingqing , Yang Haiyuan , Yang Yang , He Xin , Lan Linjing , Li De , Wu Zhigang
Published: January 2025

Particleboards were prepared with thinning wood of Cunninghamia lanceolata (Chinese fir) and wood shavings of waste Uncaria sinensis branches by using melamine-urea-formaldehyde resin as the adhesive. Influences of particle mass ratio of C. lanceolata to Uncaria, adhesive loading, and target density on internal bonding strength (IB), modulus of rupture (MOR), modulus of elasticity (MOE), thickness swelling rate of water absorption (TS), and water absorption (WA) of the composite particleboard were investigated. Results showed that: (1) IB, MOR, MOE, 2h-TS, and 2h-WA of pure C. lanceolata particleboard met service requirements of type-P2 furniture particleboard of GB/T 4897-2015. (2) With the increase of Uncaria particles, IB of composite particleboard decreased gradually, while MOR, MOE, TS, and WA first increased and then decreased. The best comprehensive performances were achieved when the mass ratio of C. lanceolata to Uncaria was 75:25, manifested by 1.5 MPa of IB, 21.3 MPa of MOR, 2140 MPa of MOE, 2.4% of 2h-TS and 12.3% of 2h-WA. These performances basically meet the service requirements on type-P3 of the standard. (3) It can make C. lanceolata fir/Uncaria particleboard meet requirements on type-P4 heavy-load particleboard of the standard by increasing target density and adhesive loading appropriately. (4) The C. lanceolata/Uncaria composite particleboard showed higher thermostability and fire resistance.
Deconstructing the Gender Stereotypes of the Villainess in Dan Brown’s Inferno
Authors: Theodar Caleb
Published: January 2025

This study intends to contribute to the existing research about modern female villains by delving deeper into the ways that represent the stereotypical pattern in film and literature. This article examines Sienna Brooks, the primary antagonist in Dan Brown’s novel Inferno and its film version. She was Bertrand Zobrist’s lover and resolved to finish his work by unleashing his Inferno virus on humanity. Vis-à-vis, articulating feminist momentum through Sienna’s antagonism to the hero highlights the boundaries of binary oppositions, challenging literary critics and questioning gender bias in literature. Female villains have empowered characters because they are often multidimensional, stronger, and more complex than female heroines, instrumental to the story’s narrative. Brown’s block characterisations make inferences about Sienna Brooks both explicitly and implicitly, replicating Sienna’s thinking style or how she thinks about the world in her mind. The conceptual portrayal of the feminine villain narrative reflects the evolving role of women in plot construction, highlighting the need for nuanced and equitable gender representation in movies.
Treatment Challenges in a Tourette Syndrome Patient with Self-Injurious Behaviour: Case Report and Literature Review
Authors: Asadauskaitė G. , Jasionytė G. , Karnickas M.
Published: January 2025

Introduction. Tourette syndrome is known as a combined vocal and multiple motor tic disorder. It is a chronic complex neuropsychiatric disorder characterised by the onset of symptoms in early childhood and the presence of multiple motor tics and one or more vocal tics. In most cases, the symptoms resolve or become less severe in early adulthood. Nevertheless, there are some cases where the syndrome does not follow its typical clinical course.Case report. We present a 28-year-old patient with Tourette syndrome. The patient was hospitalized for complex motor and vocal tics, as well as tics resulting in self-harm. First tics began at the age of twelve and gradually intensified. The patient was diagnosed with Tourette syndrome at thirteen and has been taking Haloperidol 5 mg 3 times a day and Trihexyphenidyl 2 mg 3 times a day for the past 15 years. His condition worsened 6 months ago with increased tics, self-harm, insomnia, social withdrawal, and weight loss. In the hospital, Haloperidol was gradually replaced with 20 mg of Aripiprazole daily. The patient underwent twenty-six transcranial magnetic stimulation procedures. During hospitalization, insomnia was resolved, whereas motor tics and self-harm decreased.Discussion. The pathogenesis of Tourette syndrome emphasizes the dysfunction of neuronal networks in the basal ganglia. It leads to impaired inhibition in the sensorimotor cortex of the brain, which results in motor and vocal tics. Their characteristics are individual to each patient. The course of illness and the severity of symptoms are influenced by various stressors, intense emotional experiences, and environmental factors. Tourette syndrome is commonly treated with psychotherapy, pharmacological treatment, or a combination of these methods. The case we present shows that the conventional treatment methods are not always effective, and that the clinical course of Tourette syndrome may deviate from the usual expressions of the syndrome.
Rosa, Harmut. Demokratie braucht Religion, Kösel, München, 2022, 80 pp.
Authors: Donoso Mario
Published: January 2025

Book Review
Sada, Alejandro; Albino de Assunçao, Rudy; Rowland, Tracey. Ratzinger y los filósofos. De Platón a Vattimo, Encuentro, Madrid, 2023,554 pp.
Authors: Crespo Mariano
Published: January 2025

Book Review
Sáez Cruz, Jesús. Sobre el problema de la realidad divina. Una aproximación filosófica al misterio de Dios. Universidad Pontificia de Salamanca, Salamanca, 2023, 575 pp.
Authors: Onrubia-Miguel Luis
Published: January 2025

Book Review
Skarica, Mirko. El juicio en De interpretatione de Aristóteles. Sus comentaristas y su recepción contemporánea. EUNSA, Pamplona, 2023, 411 pp.
Authors: Podhorski Jan-M.
Published: January 2025

Book Review
Sowell, Thomas. Social Justice Fallacies. Basic Books, Nueva York, 2023, 201 pp.
Authors: Zorrilla Víctor
Published: January 2025

Book Review
Pommier, Éric. La condition sensible. Hermann, Paris, 2022, 204 pp.
Authors: Zúñiga-Iturra Bryan-Francisco , Parra-Bernal Francisco-Javier
Published: January 2025

Book Review
Examination of Isotopic Signals to Determine Trophic Dynamics and Diet of Gulf of Maine Mysticetes Prior to an Oceanographic Regime Shift
Authors: Todd Sean , Robbins Jooke , Weinrich Mason T. , Pastor Natasha , Dendanto Dan , Palsbøll Per J. , Zoidis Ann M.
Published: January 2025

Stable isotope analysis (SIA) is a useful tool to assess the health and foraging habits of large marine predators, metabolic stress, pregnancy, and migration patterns. This study provides baseline SIA data for four Gulf of Maine mysticete species and serves as a benchmark for future assessments. SIA was conducted on skin biopsies collected in two time periods: 1988 to 1992 (n = 15) and 1999 to 2005 (n = 187). Samples were collected from humpback whales (Megaptera novaeangliae; n = 116), fin whales (Balaenoptera physalus; n = 74), minke whales (Balaenoptera acutorostrata; n = 6), and North Atlantic right whales (Eubalaena glacialis; n = 6). There were statistically significant differences in isotopic value among species, years, and regions sampled. By species, North Atlantic right whale δ13C and δ15N levels were significantly different than the other species analyzed. Additionally, humpback whales had a δ15N value that was significantly higher than the value found in fin whales. By date, humpback whales showed significant difference in δ13C in 2002 from the two previous years. For fin whales, 2002 showed significant difference in δ13C for all other years’ samples (2000 to 2003). By region, two regions that were the greatest distance apart (Bay of Fundy and Great South Channel) showed significant differences in δ13C for humpback whales. Demographic analyses for humpback and fin whales found a significant difference between calves versus other age classes, presumably due to nursing. A decadal comparison of humpback whales at one site (Stellwagen Bank) found no significant difference between decades. This dataset provides a benchmark for stable isotope measurements in large baleen whales for this regional ecosystem.
The role of the radiologist in the dengue endemic: a pictorial essay
Authors: Oliveira Neto Edinaldo Gomes de , Nascimento Danilo Delamare Lucena , Bertoncini Tiago Vasques , Lopes Arthur Ataíde , Bezerra Alexandre Sérgio de Araujo , Soares Mayra Veloso Ayrimoraes
Published: January 2025

Abstract The dengue virus, a member of the family Flaviviridae, is transmitted by Aedes mosquitoes and causes a viral disease known as dengue fever that is prevalent in tropical and subtropical regions. It is estimated that there are 100–400 million new infections every year, with underreporting due to limited surveillance systems. The presentation ranges from asymptomatic to dengue shock syndrome. Brazil is now facing an endemic of dengue, having seen a significant seasonal increase of over 4.5 million in the number of probable cases reported. Imaging exams such as ultrasound, computed tomography, and magnetic resonance imaging are crucial for detecting complications of dengue, aiding in the clinical management and differential diagnosis, especially in severe cases. The aim of this study was to illustrate the radiological findings of dengue, focusing on emergency and critical care settings.
OS APETITES E A TRIPARTIÇÃO DA ALMA NA REPÚBLICA DE PLATÃO
Authors: Caram Juliano Paccos
Published: January 2025

RESUMO Ao longo da República de Platão, a instância psíquica pode ser vista como contraditória justamente em virtude de sua difícil harmonia interna. Por outro lado, também pode ser entendida como a sede motivadora das ações humanas que, se não elimina o problema do conflito e da contradição, ao menos abre a possibilidade de que a psyché se manifeste como uma unidade movida por instâncias distintas, em uma direção específica. É sobre esta segunda maneira de entender a alma, como uma unidade motivacional de impulsos distintos, em direções e prazeres também distintos, que esse texto pretende argumentar e, de modo mais central, sobre a natureza complexa dos apetites no interior desta alma em conflito. O intuito é o de demonstrar como o texto da República permite discutir o estatuto dos apetites (epithymiai) e o princípio apetitivo da alma (epithymetikon) como diferentes e que, quando não trocados um pelo outro, a teoria da alma se enche de uma clareza ainda maior e possibilita uma compreensão mais aguçada acerca da unidade da alma e de seus mais diversos apetites.
Reflexões sobre a Inserção de Médicos Assistenciais como Educadores em Hospitais Comunitários
Authors: SANTOS NETO RENÉ SCALET DOS , BRUGINSKI DANIELLE , VOLKMANN ANA FÁTIMA , MOURA NETO JOSÉ ANDRADE
Published: January 2025

RESUMO Este artigo discute os desafios e oportunidades da inserção de médicos assistenciais como educadores em hospitais comunitários, tanto nos EUA quanto no Brasil. A expansão das escolas médicas e a escassez de médicos levaram à nomeação de médicos assistenciais para funções de ensino, muitas vezes sem treinamento formal. Médicos nos EUA e no Brasil enfrentam desafios semelhantes, como falta de tempo, preparação e apoio institucional para o ensino. Hospitais comunitários oferecem oportunidades únicas de aprendizado, mas podem ter recursos limitados. O artigo destaca a necessidade de programas de capacitação docente, materiais didáticos e colaboração com centros acadêmicos para apoiar esses médicos. Conclui-se que, com o apoio adequado, a inserção de médicos assistenciais como educadores pode beneficiar tanto a formação médica quanto os serviços de saúde em áreas carentes.
Comments on “Reflections on the Inclusion of Direct-Care Physicians as Educators in Community Hospitals”
Authors: SLULLITEL ALEXANDRE
Published: January 2025

ABSTRACT We discuss the arguments exposed in the Letter to the Editor “Reflections on the Inclusion of Direct-Care Physicians as Educators in Community Hospitals”, exploring the teaching competencies necessary for community preceptors in the context of medical education, highlighting the growing responsibility of these professionals in the training of future physicians in health-deprived regions. From a narrative review, we analyze faculty development (FD) programs, emphasizing their importance in improving teaching skills, creating support networks, and providing personalized content for specific challenges. Among the competence domains identified are teaching skills, evaluation criteria, professionalism, communication, and leadership/management. In addition, we suggest Entrustable Professional Activities (EPA) as tools to assess and develop these competencies. FD programs, when well structured, benefit preceptors, students, and communities, improving the quality of teaching and care outcomes.
Commentary on “Reflections on the Inclusion of Direct-Care Physicians as Educators in Community Hospitals”
Authors: ALVES ROSANA
Published: January 2025

ABSTRACT The article by Sweigart et al. presents concerns, challenges, and proposals for the current situation, both nationally and internationally, and the need for a diversity of medical care practice scenarios that simultaneously develop teaching abilities. Medical education is now conducted outside the university-affiliated teaching hospital, often in the so-called community or general hospitals dedicated to patient care. In Brazil, most of these hospitals are under municipal or state management.
Violência contra as crianças durante a covid-19: aprendizagens deixadas pela pandemia
Authors: Gonçalves Felipe Souza , Machado Dinair Ferreira
Published: January 2025

Resumo: O estudo analisou a violência doméstica contra crianças no Brasil, focando o patriarcado e as políticas de proteção social. Com base em dados secundários de notícias publicadas entre março de 2020 e agosto de 2021, identificaram-se 134 matérias envolvendo 150 crianças, predominando meninos (64%) e idades médias de 5,5 anos, sendo o pai o principal agressor (31,3%). Notou-se um aumento dos casos com o distanciamento social da covid-19, desafiando a visão idealizada da família como um espaço seguro.
Capacitação em cuidados paliativos: uma amostra das Oficinas Itinerantes do Rio de Janeiro, Brasil
Authors: Mendes Ernani Costa , Santos Ana Paula Menezes Bragança dos , Olario Patricia
Published: January 2025

Resumo: O artigo aponta a necessidade de se estimular a educação permanente em cuidados paliativos. Objetiva apresentar resultados da pesquisa exploratório-descritiva “Oficinas Itinerantes em Cuidados Paliativos”, fundamentada em Paulo Freire, conduzida em unidades de saúde, envolvendo profissionais e gestores. Foi utilizado um questionário on-line para a coleta de dados, contabilizando 62 participantes. Dentre os achados, destacou-se uma deficiência na capacitação profissional em cuidados paliativos.
Itinerários terapêuticos compartilhados por usuários de serviços especializados de saúde mental: uma análise por clusters
Authors: Silva Michelle Chanchetti , Treichel Carlos Alberto dos Santos , Onocko-Campos Rosana Teresa
Published: January 2025

Este estudo teve como objetivo identificar a existência de itinerários terapêuticos compartilhados por usuários de serviços especializados de saúde mental em um município de médio porte. Trata-se de um estudo transversal, realizado entre agosto e novembro de 2019 com 341 usuários de serviços especializados de saúde mental do Município de Itatiba, São Paulo, Brasil. Para identificação dos itinerários, a partir de um conjunto de variáveis, os usuários foram agrupados por meio da técnica de cluster. A melhor medida de silhueta de coesão e separação (> 0,3) para os clusters foi alcançada a partir de quatro variáveis: situação em que o problema de saúde mental foi identificado; local do primeiro atendimento; origem do encaminhamento para o serviço atual; e manutenção do vínculo com a atenção primária à saúde (APS). Os clusters identificados no estudo demonstraram: (1) baixa participação da APS no acolhimento dos casos novos com a maioria dos atendimentos acontecendo já em serviços especializados; (2) alta proporção de casos identificados em situações de crise; (3) baixa participação da APS na referência dos casos, com elevado acesso aos serviços especializados por meio de demanda espontânea; (4) falta de continuidade do cuidado na APS após a entrada no serviço especializado. Este estudo apontou para fragilidades importantes na rede de serviços estudada, evidenciando a necessidade de desenvolver estratégias que fomentem a integração dos serviços, especialmente no que se refere à APS, tanto para favorecer o acesso aos cuidados especializados em tempo oportuno como para viabilizar a continuidade do cuidado entre os diferentes pontos de atenção.
SURGICAL TREATMENT OF GASTRIC STUMP CANCER: A COHORT STUDY OF 51 PATIENTS
Authors: DRIZLIONOKS Eric , TERCIOTI JUNIOR Valdir , COELHO NETO João de Souza , ANDREOLLO Nelson Adami , LOPES Luiz Roberto
Published: January 2025

ABSTRACT BACKGROUND: Gastric stump neoplasia is defined as a neoplasia that arises in the gastric remnant after at least 5 years of interval from the first gastric resection. AIMS: The aim of this study was to analyze 51 patients who underwent total and subtotal gastrectomy and multi-visceral resections in patients with gastric stump cancer. METHODS: The hospital records of 51 patients surgically treated for gastric stump cancer between 1989 and 2019 were reviewed. The following data were analyzed: sex, age group, the interval between the first surgery and the diagnosis of gastric stump cancer, location of the ulcer that motivated the gastrectomy, type of reconstruction, tumor resectability, surgery performed, reconstruction of the digestive tract, associated surgical procedures, postoperative complications using the Clavien-Dindo classification, disease staging, and survival. RESULTS: There were 43 (83.3%) men, with a mean age of 66.9 years. The mean interval between the initial gastrectomy and surgery for the treatment of gastric stump neoplasia was 34.7 years. All had previously undergone Billroth II reconstruction. Most patients underwent total gastrectomy (35 cases – 68.6%), followed by subtotal gastrectomy (6 cases – 11.8%), and the remainder were considered unresectable (10 patients – 19.6%), undergoing jejunostomy for nutritional support. Multi-visceral resections consisted of splenectomies, cholecystectomies, hepatectomies, partial colectomies, pancreatectomies, enterectomies, and nephrectomies. Among the patients who had the lesion resected, the mean follow-up time was 34.2 months (standard deviation: 47.6 months), the overall survival at 3 years was 43.6%, and the survival at 5 years was 29.7%. CONCLUSION: The treatment of gastric stump neoplasia is still challenging and difficult, and personalized follow-up strategies should be focused on high-risk patients, offering opportunities for early intervention, better clinical outcomes, and long-term survival.
CHOLANGIOCARCINOMA: EPIDEMIOLOGY, HISTOPATHOLOGY, AND POTENTIAL PROGNOSTIC AND THERAPEUTIC IMPLICATIONS IN A COHORT FROM A REFERENCE CENTER IN SOUTHERN BRAZIL
Authors: BERTINATTI João Pedro Pattussi , MARÇAL Josenel Maria Barcelos , CAMBRUZZI Eduardo , LEÃO DE ALENCAR Dido Eliphas
Published: January 2025

ABSTRACT BACKGROUND: Cholangiocarcinoma (CCA) is a rare neoplasm, with high mortality, originating in the bile ducts. Its incidence is higher in Eastern countries due to the endemic prevalence of liver parasites. Factors such as metabolic syndrome, smoking, and pro-inflammatory conditions are also linked to the disease. Clinical features include asthenia, abdominal pain, cholestasis, and increased serum levels of CEA and CA19-9. AIMS: The aim of this study was to evaluate CCA prevalence, survival, and potential prognostic and therapeutic implications in a patient cohort and assess correlations with clinical laboratory data and possible associated risk factors. METHODS: This is a retrospective study of the clinical and histological data of patients diagnosed with CCA at Santa Casa de Misericórdia in Porto Alegre, Brazil, between 2016 and 2021. RESULTS: There was a 56% prevalence of CCA in women, with intrahepatic localization in 55.4% of cases and unifocality in 85.6% of patients. The mean age of the patients was 63 years (26–89 years), with a mean tumor size of 5.5 cm. The median survival time was 7 months (0 to >50). CA19-9 was altered in 81% of patients, whereas GOT/GPT was altered in 62.5% and gamma-glutamyl transferase/alkaline phosphatase/bilirubin in 69.1% of patients. Mortality was higher among patients with extrahepatic CCA. CONCLUSION: Risk factors such as smoking, cholecystectomy, cirrhosis, intrahepatic lithiasis, and transplantation should be considered individually by the attending physician for radiological monitoring and incidental discovery of the neoplasm. Lack of timely identification by the attending physician can delay diagnosis, increasing mortality.
Forensic examinations in the investigations of crimes involving animals: a review
Authors: Mores Cristiano Mougenot , Castro Márcio Botelho de , Melo Cristiano Barros de
Published: January 2025

ABSTRACT: In the investigation of crimes involving animals and animal-origin products or by-products, forensic veterinary medicine plays a crucial role through examinations and analyses of evidence related to the cases. In addition to veterinary forensics, other forensic sciences frequently contribute to solving these types of crimes. Drawing on the extensive experience of the Federal Police’s criminal investigations in Brazil and the specialized forensic veterinary and scientific expertise developed at the stricto sensu Graduate level at the University of Brasília, this review provides an updated and comprehensive analysis of the most relevant expert examinations supporting investigations into animal-related crimes, with a focus on the Brazilian context. The review covers key aspects of forensic examinations conducted by criminal experts, including forensic entomology, forensic toxicology, imaging techniques, taxonomic identifications, bird rings, investigations of mistreatment, forensic veterinary pathology, forensic genetics, and isotope ratio analysis. The field of veterinary forensics, with its diverse resources, established techniques, highly trained and continually updated experts, and the latest advancements in criminalistics, is essential for properly addressing judicial demands.
De-Romanticizing the History of Slavery in the United States: The Tragic Mode in Saidiya Hartman’s Scenes of Subjection
Authors: PEREIRA ALLAN KARDEC DA SILVA
Published: January 2025

ABSTRACT This article starts with Scenes of Subjection, the first book published by African-American historian Saidiya Hartman, to reflect on the forms of narrating the past of slavery. First, I briefly overview slavery historiography in the United States and describe her place in this scenario. Then, I present some of the problematizations elaborated by historian Hayden White about the forms of past entanglement in the writing of history, something that is essential to understanding the work developed by Hartman and which relates to the next subtopic, in which I discuss the narrative possibilities of tragedy and the tragic. Finally, I discuss how, by applying these demands, Scenes of Subjection provokes us to think, theoretically and methodologically, about other forms of writing slavery history.
In vitro study reveals antimicrobial activity of essential oils against Klebsiella pneumoniae isolates from Nile tilapia
Authors: Vaneci-Silva D. , Nakamura-Silva R. , Oliveira-Silva M. , Pitondo-Silva A. , Assane I. M. , Pilarski F.
Published: January 2025

Abstract Recent studies have shown a growing presence of Klebsiella pneumoniae in aquatic environments, raising concerns for fish production due to its resistance to many antimicrobials. This bacterium is commonly associated with urinary tract infections, pneumonia, and septicemia in humans. Controlling bacterial infectious diseases in fish is a significant challenge in aquaculture. In Brazil, only florfenicol and oxytetracycline are approved for use in this sector. Therefore, in this study, we assessed the in vitro antibacterial impact and hemolytic activity of 16 essential oils (EOs) and two frequently used antimicrobial agents in aquaculture (florfenicol and oxytetracycline) against seven strains of K. pneumoniae isolated from Nile tilapia. The EOs were characterized chemically using gas chromatography with a flame ionization detector and verified with mass spectrometry. The microdilution technique using 96-well plates was employed to evaluate the minimum inhibitory concentration (MIC), ranging from 0.078125 to 20 µg mL-1 for essential oils (EOs) and from 0.0075 a 64 µg mL-1 for antimicrobials. To determine the minimum bactericidal concentration (MBC), 10 µL aliquots from wells that did not show growth in the MIC tests were cultured on Petri dishes containing Muller Hinton Agar. The hemolytic activity of the EOs was evaluated using an erythrocyte lysis assay. The primary components of Thymus vulgaris were thymol (53.3%) and p-cymene (20.8%), while those of Melaleuca alternifolia were 1-terpinen-4-ol (40.5%), γ-terpinene (19.7%), and α-terpinene (1.6%). Significant hemolytic activity was only observed in M. alternifolia tests (>33% lysis). T. vulgaris EO exhibited the highest activity against K. pneumoniae strains, while M. alternifolia EO demonstrated MIC and MBC against all strains. EOs from Corymbia citriodora, Artemisia vulgaris, Citrus bergamia, Cananga odorata, Boswellia carterii, and Pelargonium peltatum also yielded positive results. All strains were resistant to the tested antimicrobial agents. Based on these findings, T. vulgaris was the most promising EO for treating K. pneumoniae in fish.