bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Nursing Care and Follow-up for Mothers of Infants Undergoing Congenital Heart Surgery: A Quasi-Experimental Study
Authors: AY Ayşe , KOÇ Gülten
Published: April 2022

Improvements in congenital heart surgery (CHS) have resulted in an increasing number of infants surviving, but there remain concerns about home care and difficulties experienced by mothers. This study was designed to evaluate the effect of nursing care and follow-up for the mothers of infants undergoing CHS on anxiety, care burden, and self-efficacy. The study was designed as a quasi-experimental study with a pre-test and post-test control group design. The study included 40 mothers whose infants had undergone CHS. Nursing care was provided to the mothers included in the study group through a total of six home follow-ups until the third month after surgery, guided by the North American Nursing Diagnosis Association and Nursing Diagnosis System and Nursing Interventions Classification. Data were collected through Care Needs Identification Form, Spielberger’s State-Trait Anxiety Inventory (STAI), Zarit Burden Interview (ZBI), and Parental Self-efficacy Scale (PSE). The mean STAI and ZBI scores for the mothers in the intervention group decreased, while the mean PSE scores increased as the follow-up progressed and it was determined that by the third month, the difference between the mothers in the intervention group and those in the control group in terms of post-test STAI, ZBI, and PSE had become statistically significant. Providing appropriate nursing care practices to the mothers of the infants with CHD in home setting would contribute immensely to decrease the potential problems experienced by the mothers.
Clustered Ensemble Feature Selection with M-GRU Classification for Efficient Intrusion Detection System of Industrial Systems
Authors: Karthigha M , L Latha
Published: April 2022

In today's scenario, infrastructures, such as the power grid and nuclear power plant, the industrial control system (ICS) is crucial. Yet, there is growing worry that ICS systems are susceptible to threats or attacks, and that even minor changes or manipulation could cause major damage to industrial operations. In this paper, an efficient intrusion detection system with clustered ensemble feature selection and Multi-Level Modified Gated Recurrent Unit (M-GRU) classification model is proposed. Clustered ensemble feature selection approach is to find the best feature subset. The features are ranked based on scores from base algorithms and aggregated using aggregation algorithms. Diverse base algorithms are elected using clustering technique. The features designated are fed into a multi class classification algorithm Multi-Level Modified Gated Recurrent Unit (M-GRU). NSL-KDD training and testing dataset is used in this work for feature selection and classification. The results infer that the proposed feature selection method with classification model improves accuracy and lowers false alarm rate compared to other models.
Resistance of Dickeya solani strain IPO 2222 to lytic bacteriophage ΦD5 results in fitness tradeoffs for the bacterium during infection
Authors: Czajkowski Robert , Bartnik Przemyslaw , Lewtak Kinga , Fiołka Marta , Czaplewska Paulina , Narajczyk Magdalena
Published: April 2022

Resistance to bacteriophage infections protects bacteria in phage-replete environments, enabling them to survive and multiply in the presence of their viral predators. However, such resistance may confer costs for strains, reducing their ecological fitness as expressed as competitiveness for resources or virulence or both. There is limited knowledge about such costs paid by phage-resistant plant pathogenic bacteria in their natural habitats. This study analyzed the costs of phage resistance paid by the phytopathogenic pectinolytic bacterium Dickeya solani both in vitro and in potato (Solanum tuberosum L.) plants. Thirteen Tn5 mutants of D. solani IPO 2222 were identified that exhibited resistance to infection by lytic bacteriophage vB_Dsol_D5 (ΦD5). The genes disrupted in these mutants encoded proteins involved in the synthesis of bacterial envelope components (viz. LPS, EPS and capsule). Although phage resistance did not affect most of the phenotypes of ΦD5-resistant D. solani such as growth rate, production of effectors, swimming and swarming motility, use of various carbon and nitrogen sources and biofilm formation evaluated in vitro, all phage resistant mutants were significantly compromised in their ability to survive on leaf surfaces as well as to grow within and cause disease symptoms in potato plants.
Evolution of high-temperature extremes over the main Euro-Mediterranean airports
Authors: Gallardo Victoria , Riber Eleonore , Terray Laurent
Published: April 2022

The increasing intensity and frequency of high-temperature events in response to climate change can potentially impact the aviation industry, since aircraft takeoff and landing performances depend on near-surface air temperature. Previous studies have combined climate data with aircraft technical data to estimate the future impact of rising high temperatures on aircraft takeoff. They found a decrease of maximum takeoff weights and the lengthening of takeoff distances. The Mediterranean region is a climate change ”hot spot” area, specially concerned by extreme high-temperatures increase. In this study, the amplitude and trends of the daily maximum near-surface temperature extremes in summer were analysed over the main airports in Southwestern Europe. Changes in the period 1961-2014 were analysed from observations and reanalysis. Future changes by 2021-2050 and 2071-2100, with respect to 1961-2005, were analysed from simulations performed with Regional and Global Climate Models (RCMs and GCMs). Before assessing future climate projections, climate models were evaluated in present climate, and the RCM and GCM ensembles were compared to each other. No clear added value was found for RCMs over GCMs in present climate at the airport scale in these terms. GCMs project larger temperature changes than RCMs over the same locations. Multi-Model Ensemble mean projected changes under the RCP8.5 scenario range between +1.7 and +3.2 ◦ C by the near term, and between +4.9 and +8.5 ◦ C by the long term. This dramatic increase of high-temperature extremes would deduce negative impacts on airport operations. Therefore, adaptation or mitigation policies would become necessary to face the derived socio-economic impact.
Improving sexual dysfunction through guided imagery and music (GIM): A clinical trial study
Authors: Mohammadi Elahe , AbdiShahshahani Mahshid , Noroozi Mahnaz , Mohammadi Ali Zade , Beigi Marjan
Published: April 2022

Introduction: Women with perfect health are strong foundations of a healthy and prosperous family life and suppressing the natural needs of women will have adverse effects on the intimacy and vitality of family members especially in the field of sexual function. This study aimed to determine the effect of guided imagery and music (GIM) on the level of sexual function in women with sexual dysfunction.Method: This study was performed as a clinical trial on 72 women of reproductive age with sexual dysfunction (two 36-individual groups) referred to comprehensive health centers in Isfahan, Iran. Sampling was conducted in a convenience way and by step-by-step stages of guided imagery and music. No special intervention was performed in the control group. Data collection tools were demographic characteristics questionnaire and standard questionnaire of female sexual function index. Data analysis was performed by SPSS software using descriptive and analytical statistics with 95% confidence level. Results: There was no statistically significant difference in sexual function and demographic characteristics before the intervention between the two groups (Pvalue >0.05). The results demonstrated that the overall score of sexual function in the intervention subjects was better than the control group. (Pvalue <0.05) Improvement of sexual function dimensions (desire, arousal, orgasm) were also significant in the intervention group compared to the control group (Pvalue <0.05). Conclusion: Guided imagery and music (GIM) can be effective in improving women sexual function. This technique is recommended for reproductive age women with sexual dysfunction or women who want to enhance sexual function.
CELF Pretreatment Improves Ethanol Titers from High Solids SSF of Hardwood Poplar
Authors: Sengupta Priya , Wyman Charles E. , Cai Charles M.
Published: April 2022

Woody biomass is not only abundant and sustainably available but also contains more glucan than most agricultural feedstocks. However, its structural strength and density make it more recalcitrant to enzymatic breakdown and limit SSF performance, especially at higher solids loadings needed to achieve desired ethanol titers. Because Co-Solvent Enhanced Lignocellulosic Fractionation (CELF) highly enriches glucan contents in pretreated solids by removing and recovering most of the hemicellulose and lignin, we hypothesized that the greater glucan in SSF at solids loadings that inhibit mixing than possible for other pretreatments would make it possible to achieve higher ethanol titers and yields. Application of a fractal kinetic model to data from enzymatic hydrolysis of CELF pretreated poplar indicated that CELF solids could sustain high cellulase enzyme activity over the entire course of hydrolysis with minimal enzyme deactivation. Model parameters further suggested that increasing enzyme loadings beyond 15 mg protein/g glucan in raw poplar would not increase saccharification performance. Based on these predictions, SSF was applied to solids produced by CELF pretreatment of poplar using Cellic® CTec2 cellulase at a loading of 15 mg-protein/ g-glucan in combination with S. cerevisiae D5A. At CELF solids loadings of 13, 17, and 20 wt%, SSF realized ethanol titers of 60, 78, and 87 g/L and yields of 87, 84, and 79% of theoretical in respective orders of increasing solids loadings. Furthermore, sugar release was sustained throughout SSF, irrespective of solids loading, suggested that yeast ethanol tolerance and metabolic capability and not glucan digestibility limited SSF performance.
RETRACTED: The association between serum folate and osteoporosis in adults: based on the National Health and Nutrition Examination Survey
Authors: Li Senjie , Lv Dongqing , Yang Hong , Yan Shaoyi , Wu Lei , Jia Yongping
Published: April 2022

The authors have requested that this preprint be removed from Research Square.
Prognostic Value of Iron Metabolism-Related Genes in Bladder Urothelial Carcinoma
Authors: He Chengyan , Lu Hezhen , Yue Siqi , Yang Zhaowei , Pan Junqi
Published: April 2022

Background: Iron metabolism-related genes have shown good predictive value for the prognosis of many solid tumours. However, iron metabolism-related genes have not been reported as prognostic biomarkers in bladder urothelial carcinoma.Methods: In this study, gene expression data and clinical data were downloaded from The Cancer Genome Atlas database. Differential gene expression analysis, univariate Cox regression analysis and the least absolute shrinkage and selection operator regression algorithm were used to screen prognostic iron metabolism-related genes and to construct a risk scoring model. Kaplan-Meier survival plots and receiver operating characteristic curve analysis were used to evaluate the prognostic performance of the risk scoring model in the TCGA-BLCA cohort. In addition, a nomogram model with the risk score was established, and its predictive performance was verified by receiver operating characteristic analysis and calibration plot analysis in the TCGA-BLCA cohort. Gene set enrichment analysis identified pathways and biological processes that may be enriched in the high-risk group. Finally, immune infiltration analysis was used to explore the characteristics of the tumour microenvironment related to the risk score. Results: We identified 14 iron metabolism-related genes with prognostic value and constructed a risk scoring model. Receiver operating characteristic analysis showed that the risk scoring model can accurately predict the 1-year, 3-year, and 5-year overall survival of BLCA patients in the TCGA-BLCA cohort. Kaplan-Meier analysis showed that the overall survival of the high-risk group was significantly lower than that of the low-risk group (P<0.001). The nomogram model effectively predicted the overall survival of BLCA patients in the TCGA-BLCA cohort. Gene set enrichment analysis indicated that iron metabolism-related genes may be involved in biological processes such as developmental processes, the cell cycle, mitosis, the RHO GTPase response, DNA repair, and extracellular matrix regulation. Immune infiltration analysis showed that the level of immune cell infiltration in the high-risk group was high, and the risk score was positively correlated with infiltrating immune cells. Conclusions: Our prognostic model based on iron metabolism-related genes in BLCA could help the prognostic assessment of BLCA patients and provide potential targets for BLCA inhibition.
Dietary fat enhanced chylomicron-mediated LPS translocation in a Caco-2 transwell model
Authors: Tomassen Monic M.M. , Govers Coen , Vos A. Paul , de Wit Nicole J.W.
Published: April 2022

Background
There is increasing evidence that dietary fat, and especially saturated fat, promotes the absorption of lipopolysaccharide (LPS) via enhanced chylomicron production. The latter can subsequently transport LPS to other parts of the body, where it can induce low-grade chronic inflammation that links to various metabolic and gut-related diseases. To identify promising (food) compounds that can prevent or ameliorate LPS-related low grade inflammation, we developed and optimized an in vitro model for dietary fat-induced LPS translocation that mimics the in vivo situation and facilitates high-throughput screening.
Results
Differentiated Caco-2 cells were exposed to in vitro digested palm oil and sunflower oil in a dilution range, with or without starvation to optimize chylomicron production. To measure fat-induced chylomicron production, basolateral levels of the chylomicron-related marker apolipoprotein B (ApoB) were assessed. An optimal production was found after apical exposure to digested oils in a 1:50 dilution, preceded by one-week starvation (cultured without fetal bovine serum). Next, LPS was co-incubated in various concentrations with the digested oils and fat-induced LPS translocation to the basolateral side was assessed. We found that dietary fat-induced LPS translocation in Caco-2 cells was optimal after apical exposure to the digested oils in combination with 750ng/ml LPS. Subsequent co-incubation with the chylomicron blocker Pluronic L81 indicated that the fat-induced LPS translocation was at least partly mediated by chylomicrons.
Conclusions
We developed a robust Caco-2 cell model for dietary fat-induced LPS translocation that can be used for high-throughput screening of (food) compounds that can reduce LPS-related low grade inflammation.
Unlocking Phenotypic Plasticity Provides Novels Insights for Immunity and Personalized Therapy in Lung Adenocarcinoma
Authors: Wang Feng , Du Hongjuan , Li Bibo , Luo Zhibin , Tang Min , Zhu Lei
Published: April 2022

Background
Unlocking phenotype plasticity (UPP) has been shown to have an essential role in the mechanism of tumor development and therapeutic response. However, the clinical significance of unlocking phenotypic plasticity in patients with lung adenocarcinoma is unclear. This study aimed to explore the roles of unlocking phenotypic plasticity in immune status, prognosis and treatment in patients with lung adenocarcinoma (LUAD).
Methods
Differential expressed genes (DEGs) and clinical information of UPP were selected from the cancer genome atlas (TCGA) database, and the GO, KEGG enrichment analyses were performed. The independent prognostic genes were determined by univariate and multivariate Cox regression, and the UPP signature score was constructed. Patients with LUAD were divided into high- and low-risk groups according to the median of score, and the immunocytes and immune function, the gene mutation, drug sensitivities between the two groups were analyzed. Finally, the results were validated in the GEO database.
Results
Thirty-nine significantly differentially expressed genes were determined. Enrichment analysis showed that UPP-related genes were related to protein polysaccharides and drug resistance. The prognostic results showed that the survival of patients in high-risk group was poorer than that in the low-risk group (P < 0.001). In the high- and low-risk groups, single nucleotide polymorphism (SNP) and C > T are the most common dissent mutations. The contents of immune cells were significantly different between high- and low-risk groups. And the immune functions were also significantly different, indicating that UPP affects the immunity in LUAD. The results from TCGA were validated in the GEO.
Conclusion
Our research has proposed a new and reliable prognosis indicator to predict the overall survival. Evaluation of the UPP could help clinician to predict therapeutic responses and make individualized treatment plans in patients with LUAD.
Ubiquitin-Like Conjugation by Bacterial cGAS Enhances Anti-Phage Defense
Authors: Chen Zhijian (James) , Jenson Justin , Li Tuo
Published: April 2022

cGAS is an evolutionarily conserved enzyme that plays a pivotal role in immune defense against microbial infection1-3. In vertebrate animals, cGAS is activated by DNA to produce cyclic GMP-AMP (cGAMP)4,5 , which initiates a signaling cascade leading to the expression of a battery of immune defense genes6,7. In bacteria, cyclic dinucleotide (CDN)-based anti-phage signaling systems (CBASS) have been discovered8-11. These systems are composed of cGAS-like enzymes and various effector proteins that either kill bacteria or inhibit bacterial growth upon phage infection, thereby stopping phage spread. Of the CBASS systems reported, ~39% contain Cap2 and Cap3, which encode proteins with homology to ubiquitin conjugating (E1/E2) and deconjugating (DUB) enzymes, respectively8,12. Although these proteins have been shown to be required to prevent infection of some bacteriophages8, the mechanism by which the enzymatic activities exert anti-phage effect is unknown. Here, we show that Cap2 forms a thioester bond with the C-terminal glycine of bacterial cGAS and promote conjugation of cGAS to target proteins in a process that resembles ubiquitin conjugation. Mutations of the C-terminal glycine of cGAS abrogated its anti-phage activity in several CBASS systems, recapitulating the effect of mutating the active site cysteines of E1- and E2- like domains in Cap2. The covalent conjugation of cGAS increased the production of cGAMP. Through a genetic screen with mutagenesis of T4 phage, we identified the phage protein Vs.4. that antagonizes the effect of cGAS conjugation catalyzed by Cap2. Vs.4 bound to cGAMP with a Kd of ~30 nM and sequestered it. A crystal structure of Vs.4 bound to cGAMP showed that Vs.4 formed a hexamer that bound to three molecules of cGAMP. These results reveal a ubiquitin-like conjugation mechanism that regulates cGAS activity in bacteria and illustrate an arms race between bacteria and viruses through controlling the levels of CDNs.
Increasing Generalizability: Naïve Bayes Vs K-Nearest Neighbors
Authors: Pasha Fahad Mansoor
Published: April 2022

Marketing research is often criticized for lacking generalizability and inability to reproduce results. The problem lies in using models to fit data, rather than determining the predictive power of models in conditions of uncertainty. For instance, how does the predictive power of a model change when customer dynamics change? The current study suggests that marketing researchers can supplement existing research methods with non-probabilistic prediction methods, such as the kNN algorithm-based model. Unlike probabilistic models that rely on past outcomes to predict future events – and lose predictive power when newer events are observed - non-probabilistic models better capture uncertainty. In the current study, the predictive power of the kNN algorithm-based model and the Naïve Bayes model is compared using data from two real markets. The kNN algorithm-based model provides more accurate predictions, showing the utility of combining the kNN algorithm-based model with existing marketing research to improve the predictability and generalizability of models. Implications for research and future research are discussed.
Occupational health hazards among healthcare providers and ancillary staff in Ghana: a scoping review
Authors: Tawiah Philip Apraku , Baffour-Awuah Alberta , Effah Emmanuel Sintim , Ashinyo Mary Eyram , Alhassan Robert Kaba , Appiah-Brempong Emmanuel , Afriyie-Gyawu Evans
Published: April 2022

Background The safety of healthcare workers is a pathway to providing safe care to patients and their relatives, and yet healthcare providers and ancillary staff in developing countries such as Ghana are continuously exposed to occupational health hazards. The strict implementation of occupational health and safety policies seeks to curb these exposures. However, empirical evidence including reviews that are needed to affirm these policies is lacking in Ghana. This review primarily explored the types and prevalence of exposure to occupational health hazards among health workers in Ghana.Methods A scoping review design was employed for this study. A systematic search strategy was used to identify articles in PubMed, MEDLINE, CINAHL, Embase, PsycINFO, Scopus and Google scholar databases and search engines covering the period of 1 January 2010 to 30 November 2021. Additionally, key studies reference lists, and sources of grey literature were also searched to identify relevant articles. The articles were screened, and data of included articles were extracted and subsequently synthesized. The review considered only quantitative studies. An extensive protocol to this review has already been published elsewhere.Results Our systematic search strategy retrieved 507 publications; however, only 43 met the inclusion criteria. Healthcare professionals in Ghana were exposed to non-biological occupational hazards (stress, burnout, musculoskeletal injuries and violence), biological occupational hazards (sharp-related injuries, blood and body fluids and COVID-19 infection). But studies on exposure to non-biological hazards (34.9%) were more compared to biological hazards (20.9%). Averagely, health care workers utilized and complied to control/preventive measures (compliance to hand hygiene, face mask, infection prevention and control guidelines, hepatitis B vaccine uptake, adherence to HIV post-exposure prophylaxis protocol). Further, there was suboptimal knowledge of control/preventive measures (post-exposure prophylaxis, standard precautions, tuberculosis infection prevention and control measures, risk of exposure to occupational health hazards) among the healthcare personnel.Conclusion The menace of occupational health hazards in the health care sector of Ghana needs more attention. Though this review supports the existing data for occupational health and safety policy, more research is needed to understand the extent of these exposures and their effects on the health system.
Direction-of-Arrival Estimation in Non-Linear Array with Gain-Phase Error Compensation.
Authors: G Prabha , s Natarajamani , S Kirthiga
Published: April 2022

Gain and phase error sensitivity of the array output is common to all high-resolution direction of arrival estimators. In this paper, we addressed the estimation of directions of arrival of multiple signals impinging on a non-uniform linear array in the presence of gain and phase perturbations. The effect of amplitude and phase distortion on a non-uniform array with defective or missing elements is considered. An iteration method is proposed to estimate and compensate for these errors to ensure maximum accuracy in DOA estimation. Computer simulations are shown to verify the efficacy of the proposed algorithm with the presence of array distortions.
Analysis of behavior pattern and thermodynamic structure of Arabian Anticyclone in early onset of precipitation in south and southwest of Iran
Authors: Lashkari Hassan , Mohammadi Zainab
Published: April 2022

In Iran, due to its geographical location to the general circulation of the atmosphere and atmospheric systems adjacent to the time distribution of precipitation is not uniform. In the southern part, the main focus of the precipitation period is in autumn and winter, and by moving to the middle and northern latitudes, the precipitation period gradually lengthens and covers the autumn to spring seasons. According to the country's agricultural calendar, precipitation l is expected to start in early or mid-October. But in practice, due to the planetary and regional circulation characteristics, it sometimes happens sooner or later than normal conditions The purpose of this study is to identify synoptic patterns as well as the role of Arabian Anticyclone (AA) in the early onset of precipitation in south and southwestern Iran. For this purpose, daily precipitation of synoptic stations in the south and southwest of Iran in a statistical period of 36 years was extracted and based on the criteria set, early precipitation years were determined. Dominant synoptic patterns in these years were extracted using factor analysis and ocular inspection methods. In the following, the vertical structure and spatial displacement of the Arabian anticyclone have been investigated. The results of this study showed that in both patterns, Arabian anticyclone has been removed from its summer pattern earlier than normal conditions and according to the pressure level, it has been established in the area between the Hormoz Strait and the Aden Gulf. In both patterns, about 7 to 10 days before the onset of rainfall, a deep ridge of African anticyclone with the expansion of Northern (blocked in a pattern on northern Europe) intensifies the northern flows over the eastern Mediterranean and north-east Africa. This pattern with cold advection; in addition to deepening the Mediterranean trough and intensifying the activity of the Sudanese system is by the eastward displacement of the Arabian anticyclone. The vertical and horizontal profiles showed the eastward displacement of the Arabian anticyclone cores at least 15 days before the early precipitation.
The Value of Digital Communication
Authors:   Saint Petersburg State University, Nigmatullina Kamilla R.
Published: April 2022

The publication is devoted to the value foundations of mass communication on the sites of local news media in social networks. The relevance of the work is related to the growth of news media audiences on digital platforms and the need to involve subscribers in the life of communities based on common values. Scientific novelty is expressed in the analysis of the still unexplored formation of local communities and their values on digital platforms. The author poses the question of harmonizing communication based on constructive values, as well as the values of communication itself that support media in social ecosystems: involvement, exchange of emotions based on information, ease of demonstrating support or disapproval, direct communication with opinion leaders. The general problem of the research is designated as the axiological ambivalence of communication in the digital environment. The work used a systematic review of the literature and a qualitative generalization of the results of the author’s previous studies related to the practice of local communities on digital platforms. The review showed the presence of common characteristics for all the results obtained. Among them is the imbalance of communication depending on the region and local politics, as well as the presence of negative emotions and fake information in communications, while people tend to spread negative content of posts / actively react to them. Finally, the volume of communication itself on social networks is uneven in specific topics, periods of time and for audiences of different regions.The study showed that the value of communication in local media on digital platforms lies in the ability of messages to form values that unite the audience and neutralize radicalizing ones, to form a constructive discussion (with the search for solutions to the conflicts that have arisen), taking into account the different value foundations of the communication participants. The values of local communities are concentrated not only around local patriotism, civic activism and proactivity ‒ the named triad is able to harmonize radicalized discussions on digital platforms.
Transformation of a Literary Character’s Identity in the Artistic Mirror of Buryat Novels: from Soviet to Рost-Soviet
Authors:   Institute of Foreign Languages, Shanghai Jiao Tong University, Ruge Jing , Boldonova Irina S. ,   Nankai University
Published: April 2022

In this article, the authors make an attempt based on an analysis from the point of view of neo-historicism to look again at the history of the development of Buryat novels, to analyze the features of constructing the identity of the main characters in works written by famous Buryat writers at different historical stages. The relevance is due to the absence of scientific works devoted to identifying the transformation of the identity of literary characters under the influence of historical eras. The purpose of this article is also to study the influence of various historical contexts on the work of writers in order to find out the pattern of manifestation of the ethnic identity of the Buryats in the historically determined dynamics of social development and their artistic embodiment. The most famous novels by Buryat writers of the 20th century served as the material for the study. Being a significant genre of Buryat literature, the novel has a natural connection with history since its inception, which makes it another channel for understanding the influence of the historical process on the identity of the Buryats. The authors analyze Buryat novels, which are an artistic medium for Buryat writers, with which they can write about national identity. Buryat novels are influenced by the social and historical environment and have features at different stages of history. Historical events and characters depicted in Buryat novels reflected the process of identity transformation in artistic form. The authors come to the conclusion that the identity of the heroes goes through stages from the desire for unification under the influence of Soviet ideology to the formation of a new identity of a USSR citizen, and to the conclusion about the revival of ethnic identity at a new stage. The research perspectives include the study of the transformation of identity in other genres of Buryat literature.
PENGARUH PENERAPAN PPKM DARURAT PADA MASA PANDEMI COVID-19 TERHADAP PENURUNAN PENDAPATAN UMKM
Authors: Nasruddin Nasruddin , Yansari Qomariyah
Published: April 2022

Abstrak: Penerapan PPKM Darurat bertujuan untuk mengurangi angka paparan Covid-19 sehingga dapat memutus rantai penularan virus. Penelitian ini bertujuan untuk menguji pengaruh penerapan PPKM Darurat terhadap penurunan pendapatan UMKM dengan menggunakan aplikasi pengolahan data spss 16.0. Penelitian ini melibatkan 30 orang responden yang terdiri dari pelaku UMKM di Desa Bandungsari, Sukodadi, Lamongan. Berdasarkan hasil penelitian menunjukkan bahwa terdapat pengaruh penerapan PPKM Darurat terhadap penurunan pendapatan bagi pelaku UMKM selama masa pandemi Covid-19. Pelaku UMKM yang sebelumnya bisa mendapatkan pendapatan lebih dari Rp300.000 per hari, pendapatannya menjadi merosot drastis hingga kurang dari Rp300.000 ketika dilaksanakan PPKM Darurat, mereka itu yang rata-rata bergerak di bidang toko kelontong, penjual sayur, dan pekerja serabutan yang memiliki usaha sampingan untuk menyambung hidup sehari-sehari. Hal tersebut terjadi akibat adanya peraturan yang membatasi jam operasional hingga pukul 20.00 WIB, adanya ketentuan makan/minum di tempat umum, misalnya bagi pemilik warung makan dilarang untuk melayani dine-in, serta membatasi 50 persen pengunjung yang membeli makanan dan minuman untuk dibawa pulang atau dengan menggunakan jasa pengantar makanan.
Kata Kunci: PPKM Darurat; Pandemi Covid-19; Penurunan Pendapatan UMKM; Pelaku UMKM
 
Abstract: The implementation of the emergency public activity restriction (Emergency PPKM) aims to reduce the number of exposure to Covid-19 so that it can break the chain of virus transmission. This study aims to examine the effect of implementing emergency public activity restrictions on the decline in MSME income by using the SPSS 16.0 data processing application. This study involved 30 respondents consisting of MSME actors in Bandungsari Village, Sukodadi, Lamongan. Based on the results of the study, shows that there is an effect of implementing emergency public activity restriction on the decline in income for MSME actors during the Covid-19 pandemic. MSME actors who previously could earn more than Rp300,000 per day, their income fell drastically to less than Rp300,000 when the emergency public activity restriction was implemented, they are mostly engaged in grocery stores, vegetable sellers, and freelancers who have a side business to survive daily. This situation occurs due to regulations that limit operating hours to 8 pm, provisions for eating/drinking in public places, for example, food stall owners are prohibited to serve dine-in, and limiting 50 percent of visitors who buy food/drinks to take home or by using food delivery services.
Keywords: Emergency PPKM; Covid-19 Pandemic; Decrease in MSME Income; MSME actors
KOMERSIALISASI RAMALAN TAROT OLEH TAROT READER DI KOTA SURABAYA
Authors: Tiananda Novena Clarissa , Alie Azizah , Elanda Yelly
Published: April 2022

Abstrak: Artikel ini berbicara tentang praktik komersialisasi yang dilakukan oleh para tarot reader dan latar belakang tarot reader dalam mengkomersilkan ramalan tarot tersebut. Penelitian ini menarik karena terjadi di kalangan anak muda dan wilayah perkotaan yang cenderung rasional namun dalam kehidupannya masih percaya terhadap ramalan. Hal ini menjadi dasar para tarot reader untuk mengkomersilkan ramalan tarot pada kaum muda di Surabaya. Penelitian ini menggunakan metode kualitatif dengan pendekatan naratif melalui wawancara dengan tarot reader dan pengguna jasanya (konsumen). Penelitian ini menggunakan teori kekuasaan dan pengetahuan Michael Foucault dimana peramal (tarot reader) menggunakan pengetahuannya untuk mengkomersilkan ramalan tarot. Hasil penelitian ini menunjukkan bahwa terjadinya komersialisasi ramalan tarot dikarenakan adanya permintaan dari pengguna jasa, peluang usaha, kesadaran bahwa ilmu meramal tarot bisa menjadi sumber ekonomi atau penghasilan. Peramal tarot mempromosikan jasanya melalui media sosial dan konvensional (dari mulut ke mulut). Praktik komersialisasi yang dilakukan oleh tarot reader mulai dari proses dealing dengan pelanggan, proses peramalan, hingga penentuan tarif jasa didominasi oleh peramal (tarot reader).
Kata Kunci: komersialisasi; ramalan tarot; tarot reader; kekuasaan, pengetahuan
 
Abstract: This article talks about the commercialization practices carried out by tarot readers and the background of tarot readers in commercializing the tarot predictions. This research is interesting because it occurs among young people and urban areas who tend to be rational, but do not believe in predictions. This is the basis for tarot readers to commercialize tarot predictions for young people in Surabaya. This study uses a qualitative method with a narrative approach through interviews with tarot readers and service users (consumers). This study uses Michael Foucault's theory of power and knowledge where fortune tellers (tarot readers) use their knowledge to commercialize tarot predictions. The results of this study indicate that the commercialization of tarot divination is due to demand from service users, business opportunities, awareness that tarot fortune-telling can generate economic resources or income. Tarot fortune tellers promote their services through social media and conventional (word of mouth). Commercialization practices carried out by tarot readers, starting from the process of dealing with customers, to service fees are dominated by fortune-tellers (tarot readers).
Keywords: commercialization, tarot divination, tarot readers, power, knowledge
SALA CIRÚRGICA PARA REMOÇÃO MULTIORGÂNICA PARA FINS DE TRANSPLANTE: CONTRUÇÃO E VALIDAÇÃO DE LAYOUT
Authors: Carvalho Edna Andréa Pereira de , De Souza Fernanda Gonçalves , Carvalho Messias Inácio da Silva , Silva Karla Rona da
Published: April 2022

O objetivo foi construir e validar um layout de sala cirúrgica para remoção multiorgânica. Estudo descritivo, exploratório de natureza qualitativa. Foram entrevistados 09 enfermeiros de 02 centros transplantadores brasileiros entre agosto e setembro de 2019. O resultado da revisão e análises das entrevistas subsidiaram a construção do layout. Para validação utilizou-se a técnica Delphi e porcentagem de concordância absoluta, com o valor mínimo de 80%. A validação se deu na primeira rodada com 100% de concordância. Nas cirúrgias da remoção a presença do enfermeiro é fundamental, este combina organização, recursos logísticos, conhecimentos e habilidades capazes de promover o ambiente adequado à realização de qualquer transplante. O layout foi validado contendo itens essenciais à realização da cirurgia de remoção. Todos os materiais foram numerados, identificados e dispostos de modo a atender múltiplas equipes. Esse instrumento poderá ser utilizado no setor saúde e ensino e contribui para a prática acadêmica e profissional concretizando a cultura do cuidado e segurança nos serviços de saúde.
To the absent reader, to those who are going to arrive
Authors: Palladini Giulia
Published: April 2022

The essay engages in conversation with the work of Pedro Lemebel, and attempts to articulate through its close reading a reflection on the stakes of epistemological care, language, and translation in contemporary globalised academia. This reflection is organized as a response to a series of texts, and stages a conversation between them: Pedro Lemebel’s Canción para un niño boliviano que nunca vio la mar (2004), the letter “White Colleagues Listen! An open letter to UK Theatre, Dance and Performance Studies” by the Network Revolution or Nothing (2020), Pedro Lemebel’s manifesto Hablo por mi diferencia (1986). Engaging in particular with the idea of “aesthetic education” advanced by Gayatri Spivak and with the reflections on language and decolonization articulated by Silvia Rivera Cusicanqui, the essay meditates on the political capacity that teachers and scholars, working in globalised neoliberal academia, can build together to attend to the urgent task of vigorously questioning the system of epistemological thinking that make possible the identification of any marker of difference.
Being in Touch: A metamorphosis of Jan Fabre’s The Castles of the Hour Blue into bodies of longing
Authors: Solakidi Sylvia
Published: April 2022

The writer searches for ways of not losing touch with people during the covid-19 pandemic and the rules of social distancing. She realizes that isolation from people has led to a parenthesis of time and isolation from the future. By re-viewing her experience from the exhibtion The Castles of the Hour Blue of the Belgian visual and theatre artist Jan Fabre that she has visited twice, she explores the possibility of a future as longing, through the concept of metamorphosis and Fabre's creative coping with time.
Power and Powerlessness in Performance
Authors: Döcker Georg , Katsouraki Eve , Siegmund Gerald
Published: April 2022

This editorial is an introduction to power / powerlessness, theatre and performance conceived as an intervention piece in three parts written by each of the three editors of this issue. The first part is an extended analysis of power and powerless in performance developed by Georg Döcker. The second part, developed by Eve Katsouraki, discusses the implications of a powerless theatre, especially during times of crisis such as the recent pandemic, and urges us to consider a new resilient model of theatre. Finally, the third part, by Gerald Siegmund, focuses on the interface between powerlessness and the aesthetics of theatre and performance. All the three interventionist parts of this introduction offer a conceptual framework upon which the articles of this issue can be seen to develop their examinations. We decided against offering descriptions of the articles themselves since each author has provided an abstract of their article.
Beta Blockers can Mask not only Hypoglycemia but also Hypotension
Authors: Koracevic Goran , Micic Sladjana , Stojanovic Milovan , Radovanovic Radmila Velickovic , Pavlovic Milan , Kostic Tomislav , Djordjevic Dragan , Antonijevic Nebojsa , Koracevic Maja , Atanaskovic Vesna , Dakic Sonja
Published: April 2022

Background:

Beta-adrenergic (β-AR) receptor blockers (BBs) are an essential class of drugs as they
have numerous indications. On the other hand, they have numerous unwanted effects that decrease the compliance,
adherence, and persistence of this very useful group of drugs.

Objective:

The paper aims to analyze the possibility that an unnoticed side effect may contribute to a less favorable
pharmacologic profile of BBs, e.g., a diminished reaction to a sudden fall in BP.

Methods:

We searched two medical databases for abstracts and citations (Medline and SCOPUS). Moreover,
we searched the internet for drug prescription leaflets (of the individual BBs).

Results:

Whichever cause of stress is considered, the somatic manifestations of stress will be (partially) masked
if a patient takes BB. Stress-induced hypercatecholaminemia acts on β-AR of cardiomyocytes; it increases heart
rate and contractility, effects suppressed by BBs. The answers of the organism to hypoglycemia and hypotension
share the main mechanisms such as sympathetic nervous system activation and hypercatecholaminemia.
Thus, there is a striking analogy: BBs can cover up symptoms of both hypoglycemia (which is widely known)
and of hypotension (which is not recognized). It is widely known that BBs can cause hypotension. However,
they can also complicate recovery by spoiling the defense mechanisms in hypotension as they interfere with the
crucial compensatory reflex to increase blood pressure in hypotension.

Conclusion:

Beta blockers can cause hypotension, mask it, and make recovery more difficult. This is clinically
important and deserves to be more investigated and probably to be stated as a warning.
Aminoquinoline-triazine Conjugates: Design, Synthesis, Antibacterial
Activity, and SAR Analysis
Authors: Bhat Hans Raj , Ansari Sajidul Hoque , Sahu Supriya , Shakya Anshul , Ghosh Surajit Kumar , Singh Udaya Pratap
Published: April 2022

Aim:

Frequent use of antibiotics is responsible for the development of antibiotic resistance;
thus, there is an urgent need for the development of new antibacterial agents that act by novel mechanism
pathways.

Objective:

The aim of the study was to develop hybrid novel 4-aminoquinoline 1,3 5-triazine derivatives
and determine their antibacterial activity.

Methods:

Novel hybrid 4-aminoquinoline 1,3,5-triazine derivatives were synthesized by nucleophilic
substitution and characterized by different spectroscopic methods. Furthermore, in silico study was carried
out with 16S-rRNA A-site (PDB id: 1J7T using Discovery Studio 2018 software) to exemplify key
structural interactions. In vitro antibacterial activity of target compounds was evaluated against three
Gram-positive and three Gram-negative bacterial strains.

Result:

In silico results have shown compound 8c to have both hydrophobic interactions (conventional
hydrogen bond interactions with A A:16, A A:17 and carbon hydrogen bond with U A:14, G A:15) and
hydrophilic interactions (G A:18G A:13, G A:15 and U A:19) along with excellent CDocker energy (-
28.2942). In vitro antibacterial results revealed that compound 8c showed better zone of inhibition against
S. aureus (gram-positive) and E. coli (gram-negative) as compared to standard drug Cefixime.

Conclusion:

Our study demonstrated that in silico study supported the experimental study, and the developed
1,3,5-triazine-4-aminoquinoline derivatives may be used as potential leads for future antibacterial
drug development.
In Silico Identification of Novel Quinoline-3-carboxamide Derivatives
Targeting Platelet-Derived Growth Factor Receptor
Authors: Mhaske Ganesh S. , Sen Ashim K. , Shah Ashish , Khiste Rahul H. , Dale Ajit V. , Sen Dhanya B.
Published: April 2022

Background:

Several computer-aided drug design (CADD) methods enable the design
and development of novel chemical entities. Structure-based drug design (SBDD) and the
knowledge of in silico methods enable the visualization of the binding process of ligands to targets
and to predict the key binding pocket sites and affinity of ligands to their target macromolecules.

Objective:

The present study was carried out to identify novel N-2-amino-N-phenyl quinoline-3-
carboxamide (AQCMs) derivatives targeting Platelet-derived growth factor receptor (PDGFR) to
cure cancer using in silico approach.

Materials and Methods:

AQCMs were designed using ChemAxon Marvin Sketch 5.11.5 software.
SwissADME and admetSAR online webserver were used to predict physicochemical properties as
well as the toxicity of compounds. Ligand-receptor interactions between quinoline-3-carboxamide
derivatives with the target receptor (PDB: 5GRN) were carried out using molecular docking technique
by employing various software like AutoDock 1.1.2, MGL Tools 1.5.6, Discovery Studio
Visualizer v 20.1.0.19295, Procheck, ProtParam tool, and PyMOL.

Results:

In silico results reveal that all designed compounds had acceptable pharmacokinetic properties,
were found to be orally bioavailable, and less harmful. Molecules from 36 to 39 showed better
docking scores as compared to standard drugs sunitinib and tasquinimod.

Conclusion:

Increase in binding energy and the number of H-bonds established by AQCMs with
below 3.40 Å distance interactions allows a valuable starting point in order to optimize compounds
for further investigation. Pharmacokinetics and toxicological profile build up the applicability of
quinoline-3-carboxamide moiety as a potential new candidate for the cure of cancer that could help
the medicinal chemists for additional extensive in vitro, in vivo chemical, and pharmacological
investigations.