bluuebunny/crossref_metadata_2025 huggingface dataset:
Agroeconomical assessment of the effectiveness of the use of plant growth regulators and micronutrients in the cultivation of sweet pepper for seeds in irrigation conditions of the Astrakhan region
Authors: Mukanov M. V. , Gulin M. A.
Published: December 2024

Relevance. Improving zonal agricultural technologies for the cultivation and seed production of vegetable crops is due to the need to increase agroeconomic and technological efficiency, production profitability and competitiveness of domestic products in a market economy and Western sanctions in order to ensure the country's food security and import substitution.

Methodology. Improving the elements of zonal agricultural technology for cultivating the new variety of sweet pepper Zarnitsa to increase the productivity and quality of seeds and reduce the costs of its seed production in a seedless culture through the use of micro fertilizers (Ultramag Boron) and plant growth regulators (Zircon R) is the goal of the ongoing research.

The objective of the research is to study and evaluate the agroeconomic efficiency of using the Ultramag Bor micro fertilizer and the Zircon, P plant growth regulator and their impact on the dynamics of plant growth and development, ripening time, yield and quality of sweet pepper seeds in the experiment.

The practical significance of the research lies in the possibility of widespread use in the real sector of the economy of plant growth regulators and micro fertilizers in non-seedling seed production of sweet pepper to improve productivity, quality and economic indicators of its cultivation in irrigated agriculture in the south of Russia.

Results. It was found that sweet pepper plants grown without seedlings using micro fertilizers and plant growth regulators during the fruiting phase had advantages over the control: in plant height by 6.1; 12.2 and 14.5%, the number of side shoots by 20; 36 and 40%, leaf weight by 5.9; 14.2 and 17.5%, average fetal weight by 3.8; 11.7 and 13.5%. The highest yield of sweet pepper in the experiment (33.6 t/ha), which exceeded the control by 3.2 t/ha (10.5%), and the highest content of vitamin C in the fruits (164 mg%), which is 8 mg% higher than in the control were noted in the variant with the combined use of micro fertilizer and plant growth regulator. Sweet pepper seeds in all experimental variants met the standard requirements (germination rate - 93-96%, germination energy - 93-95%). The highest level of profitability (109.3%) was observed in the variant with the combined use of micro fertilizer and plant growth regulator, exceeding the control by
Artificial intelligence in vegetable growing in Russia: problems and prospects
Authors: Shabanov T. Yu.
Published: December 2024

Relevance. Using artificial intelligence (AI) systems is of particular importance in the transformation of modern Russian vegetable growing.

Methods. Using the monographic method, the world and Russian practice of developing and using artificial intelligence systems is considered using the example of: CropX, John Deere, IBM Watson, AgEagle Aerial Systems, Blue River Technology, Farmwise, Taranis, Naiad Irrigation, Sustainable Agriculture Technology (SAT), Leader Technology, AgroCalypso, AgroVzglyad group of companies, Russian technologies and systems, Rostec Artificial Intelligence Competence Center, AgroBot, Kaluga Astra, Agrosystems, RosAgro, SAFMAR, AgriCo management company, Sadko agrofirm, AgroEco, AgroInvest and others.

Results, A list of problems with the use of AI in vegetable growing is identified, such as: high initial costs of implementing AI; lack of qualified personnel with the necessary knowledge in the field of IT and agronomy; high probability of technical failures, leading to losses in productivity and increased costs; difficulty of integration with existing automation systems; information security of databases; difficulty of data preparation; legal and ethical risks; lack of necessary infrastructure; unfavorable climatic conditions for the operation of AI; resistance to innovations on the part of personnel. Despite the identified problems, the prospects for using AI in vegetable growing in Russia will allow: optimizing agronomic processes; improving the quality of forecasting and monitoring; increasing the level of automation; improving the quality of data processing; improving resource manageability; increasing the level of adaptation of production to market needs; increasing adaptation to storage conditions and supply chain logistics, increasing the level of information content of technological processes.

Conclusion. Expanding the practice of using AI will increase the efficiency and sustainability of vegetable growing in the strategic perspective.
The influence of biostimulations on the yield and quality of Brassica oleracea hybrids in the Non-Chernozem zone of the Russian Federation
Authors: Markarova A. E. , Markarova M. Yu. , Nadezhkin S. M.
Published: December 2024

Relevance. It is necessary to search for methods for obtaining environmentally friendly products and reducing the pesticide load on agrobiocenoses. Biostimulants can influence the increase in the yield of vegetable crops and improve their quality, which is confirmed by numerous studies. Stimulating effects depend on a combination of various biotic and abiotic factors. The aim of the study was to assess the effect of biostimulants on the yield and quality of Brassica Oleracea in the conditions of the Central Non-Chernozem zone on heavy loamy sod-podzolic soils.

Methodology. A field experiment was carried out in the conditions of the Non-Chernozem zone of the Russian Federation on sod-podzolic soil in 2019-2021. In an experiment with two hybrids of Brassica Oleracea: F1 Zarnitsa (mid-early) and F1 Mechta (late-ripening), biostimulants Agrofil and MBK-BIS were studied for soaking seeds, seedlings and foliar treatment. The control variants were without fertilizer (absolute control) and the N90P120K150 background.

Results. The effect of mineral fertilizers on both hybrids was characterized by an increase in the weight of heads of cabbage by 11.7 and 23.5%, respectively. When treating seeds, the weight of heads of cabbage increased by 15-18% compared to the background. Additional treatment with stimulants for soaking seedlings in Agrofil and foliar treatment with the MBK-BIS preparation increased the weight of heads of cabbage in comparison with the background in the F1 Zarnitsa hybrid by 21.4 and 23.3%, F1 Mechta - by 21.4 and 25.4%. The contribution of biostimulants to the yield of the used cabbage hybrids is more pronounced in the late-ripening hybrid, which directly depends on the amount of precipitation during the growing season. The studied biostimulants contribute to an increase in the content of vitamin C, fiber, and the amount of sugars in cabbage heads.

Conclusion. Biostimulants MBK-BIS and Agrofil are effective for increasing the yield and improving the biochemical composition of the studied Brassica oleracea hybrids in the conditions of the Non-Chernozem zone of Russia.
Are Digital Education Resources Meeting the Preliminary Needs of „R.E.D. Teacher EDucation” Project?
Authors: Mara Daniel , Mara Elena-Lucia , Bocoș Mușata , Rad Dana , Hunyadi Daniel , Vanu Alina , Marcu Radiana
Published: December 2024

This study evaluates the preparedness of Romanian public pre-university teachers for digital pedagogy training as part of the R.E.D. Teacher Education project, which aims to enhance lifelong learning and educational quality, in alignment with European Union (EU) standards and Sustainable Development Goal 4 (SDG 4). Data were collected from 1,864 educators through a structured questionnaire aligned with global digital competency frameworks. Results indicate a strong interest in digital tools, though challenges remain, particularly in fostering collaboration and ensuring equitable access to digital resources. The study concludes that targeted professional development is needed to enhance teachers' digital literacy and address the digital divide. Key recommendations include improving access to digital platforms, promoting collaboration, and ensuring responsible use of digital resources to support inclusive, equitable education.
Effects of Virtual Reality as a Patient Education Tool: A Meta-analysis
Authors: Li Yun , Kim Mirim , Sutedjo Armanto
Published: December 2024

This meta-analysis aims to systematically review and synthesize existing literature on the effects of Virtual Reality (VR) on patient education outcomes. A comprehensive search was conducted across major academic databases. Data were extracted from 11 studies, encompassing a total sample size of 878 participants. Results from the meta-analysis revealed a significant positive effect of VR interventions on improving patient satisfaction (d = 0.39, CI [0.03,0.76], p
Neuroprotective Effect of Naturally Isolated Scopoletin (ISCN) from 3 Selected Ipomoea Species on Learning and Memory Impairment in Amnestic Mice Model
Authors: Khan Pathan Hujeb Afsar , Siddiqui Aquil Ur Rahim
Published: December 2024

Background: The Convolvulceae family, which includes the several climbing herbs and weeds in the genus Ipomoea, is widely used in Ayurvedic, Unani and Siddha medicine. These plants are found across India. The current study to explore the Neuroprotective effect of naturally isolated scopoletin (ISCN) compound from Ipomoea reniformis (Choisy), Ipomoea cairica (L.) and Ipomoea triloba (L.) on learning and memory impairment in amnestic Swiss albino mice model. Methods: There was no mortality observed at intraperitoneal maximum dosages up to 100 mg/kg body weight; the ISCN showed a significant safety margin. The Neuroprotective Effect of ISCN was evaluated by taking various doses (3, 6, 12 mg/kg i.p), standard piracetam (150 mg/kg; i.p) and scopolamine (1 mg/kg; i.p.)to produce amnesia in mice by using Interoceptive includes estimation of acetyl cholinesterase (AchE) activity and extroceptive animal models include the Morris-water maze (MWM), object recognition test (ORT), passive avoidance test (PAT). Result: The memory score significantly improved after dosing of ISCN and standard piracetam in comparison with scopolamine-producing amnesia in mice. Dose-dependent ISCN shows significant (P less than 0.01) improvement in Escape Latency in MWM, improvement in step-down latency in PAT, mice spent more time exploring the novel object in ORT and dose-dependent ISCN shows significant inhibition of AchE in mice brain. This finding indicates that ISCN may exert a neuroprotective effect by inhibiting the AchE enzyme. ISCN has the potential to be therapeutically beneficial for reducing some of the memory impairments linked to Alzheimer’s.
PNAE E A AGRICULTURA FAMILIAR: UM ESTUDO DA EFICÁCIA DA LEI EM MUNICÍPIOS BRASILEIROS
Authors: Fagner Frota de Vasconcelos Raimundo , Dutra de Souza Yan , Lúcio de Ávila Mário , Eduardo Delgrossi Mauro , Tavares Istvan Enrique
Published: December 2024

O Programa Nacional de Alimentação Escolar (PNAE) garante a alimentação de milhões de estudantes em todo país. O repasse de recursos financeiros federais para a alimentação dos estudantes matriculados na educação básica das redes públicas, sejam municipais, estaduais e/ou federal, visa fomentar hábitos alimentares saudáveis e combater à fome e à insegurança alimentar. Nesse sentido, o Observatório de Compras Institucionais (Observa-CI), iniciativa do Centro de Gestão e Inovação para a Agricultura Familiar (CEGAFI-UnB), analisou um conjunto de dados de oferta e demanda de alimentos da agricultura familiar (AF) dos municípios brasileiros no que se refere ao PNAE no período de 2011 a 2022, a partir dos registros divulgados pelo Fundo Nacional de Desenvolvimento da Educação (FNDE), órgão responsável pelas normas e regras do Programa. No cumprimento da Lei N°11.947/09, que obriga a compra de no mínimo 30% dos recursos da alimentação escolar com aquisição de produtos da agricultura familiar pelas prefeituras municipais,  observou-se que os municípios pequenos cumprem a lei, enquanto os municípios grandes e metropolitanos possuem mais dificuldades. Ademais, foi ressaltada a importância de uma política com base municipalista, com foco no pacto federativo em tempos de crises nacional e/ou global.
Estudio comparado desde la evaluación tradicional a la valoración transmoderna en instituciones educativas rurales de Piedecuesta
Authors: Cárdenas Oliveros Luz Marina , Mora García José Pascual
Published: December 2024

Objetivo: el objetivo del estudio comparado es develar las prácticas mediante una evaluación instrumental hacia el desplazamiento de una valoración para los saberes culturales en la comprensión de la transmodernidad desde las epistemologías del sur[1].
Originalidad/ aporte: se trata de fundamentar epistemológicamente nuevas prácticas pedagógicas de valoración en clave transmoderna basada en la ecología de saberes y en la traducción intercultural[2], para posibilitar la concordancia con la educación humanista, inclusiva, intercultural y equitativa que se promueve desde el Ministerio de Educación Nacional (MEN) en los principios del Plan Nacional de Desarrollo “Colombia, potencia mundial de la vida”.
Metodología: Paradigma: hermenéutico diatópico[3]. Interpretación que trasciende las perspectivas y contextos locales para incluir múltiples saberes. Método pluriverso[4]: se nutre del cambio de paradigma en la ciencia “sentirpensar”[5] y el hacer decolonial; proceso que es reconfigurado por pensamiento y sentimiento, dos formas de interpretar la realidad, mediante la reflexión y la emocionalidad.
Estrategias: mapeo participativo, entrevistas semiestructuradas, grupos focales y relatos comunitarios. El proceso es acompañado por 12 maestros de preescolar y básica primaria de la Institución Educativa San Francisco que presta sus servicios a las comunidades rurales de San Francisco, El Mansito, Guamo Pequeño y Blanquiscal, del municipio Piedecuesta. Con apoyo del Programa de Tutorías para el Aprendizaje y Formación Integral, del MEN.
Conclusión: se evidencian perfiles que van empoderando en sus prácticas pedagógicas elementos para una valoración en clave transmoderna que responda a los aprendizajes biocéntricos que les permita ser mejores personas y convivir en armonía con el otro y con la naturaleza.
 
[1] Mora García José Pascual "Pedagogías, paz y resiliencia en el marco del giro transmoderno" Educación. 8. Bogotá: Universidad de Cundinamarca. (2022).
https://repositorioctei.ucundinamarca.edu.co/educacion/8
 
[2] Boaventura de Sousa Santos, “Descolonizar el saber, reinventar el poder”. Montevideo: Universidad de la República y Ediciones Trilce, 2010.
[3] Boaventura de Sousa Santos, “Refundación del Estado en América Latina. Perspectivas desde una epistemología del Sur”. Editorial Abya-Yala, 2010.
[4] Ramón Grosfoguel, “Entrevista a Ramón Grosfoguel. Angélica Montes Montoya / Hugo Busso”, Polis, Revista de la Universidad Bolivariana, n.° 18 (2007).
[5] María Cándida Moraes y Saturnino de la Torre, “Sentipensar bajo la mirada autopoiética o cómo reencantar creativamente la educación”,Creatividad y Sociedad 2 (2002): 41-56.
Reflexiones sobre ética y razón
Authors: Triana Ramírez Alba Nidia
Published: December 2024

La carta que en esta oportunidad presentamos a los lectores de Revista de Historia de la Educación Latinoamericana (RHELA), en su número 43, pretende hacer una reflexión crítica en torno al significado de la racionalidad y la práctica de las relaciones éticas y políticas del mundo hoy.
Apreciados lectores, me hubiera gustado escribir estas palabras desde el mismo ángulo que otras versiones epistolares que esta revista ha presentado. Es decir, desde una versión menos temeraria y más esperanzadora, pero como pueden apreciar el mundo y la realidad en crisis, nos muestra un panorama diferente que merece una basta reflexión.
Si bien, no es la primera crisis contundente que vive la humanidad, pero sí es esta, la que atraviesa  el escenario de la modernidad, los límites de la supervivencia. Digo esto, porque cada vez lo racional y lo propiamente humano se vuelve contra la vida misma de los seres que habitamos este planeta, me atrevería a afirma, que, la ilustración fundamentada en la razón y el conocimiento, ha fracasado. Aunque ha habido crisis sociales y económicas, la historia nos muestra que ésta, la que vivimos hoy, es una crisis de la ética que atraviesa las dinámicas y los propósitos del poder y del mercado hacia un progreso exacerbado y contundente. Nada más absurdo y contradictorio que poner la razón al servicio de la destrucción.
Es un hecho, vivimos al borde del colapso y la destrucción masiva de los pueblos en cuyo seno se hallan tres detonantes fulminantes: el cambio climático, las guerras que ponen a disposición armas masivas letales y el hambre. En cada uno de estos detonantes, sin duda, ha estado presente de manera paradójica, la razón y sus fundamentos: el conocimiento científico o el irracional acto de la ignorancia, lo que hace que, la concepción humana se convierta en el principal depredador.
El Programa Académico de Desarrollo Profesional docente PADEP: a 15 años de su fundación
Authors: López Rivas Oscar Hugo , Crispín López Haydee Lucrecia
Published: December 2024

El presente trabajo intenta hacer un relato histórico breve de los sucesos que dieron vida al Programa académico de desarrollo Profesional docente identificado como PADEP/D. Este programa tiene la virtud de haber sido una construcción colectiva, producto de la iniciativa gestada por el Dr. Oscar Hugo López Rivas, quien tuvo la idea de desarrollar una serie de acuerdos base con la dirigencia magisterial para que se avanzara en la transformación de la formación docente en Guatemala, estableciendo así las bases para la creación de un nuevo sistema de formación docente para el país. Estos acuerdos han facilitado la implementación de varias acciones, la más sólida hasta ahora es el Programa Académico de Desarrollo Profesional Docentes -PADEP/d-, programa que lleva 15 años de implementación y que ha trascendido seis gobiernos, en un país en donde cada 4 años se escribe nueva historia, ya que los nuevos gobernantes dejan atrás lo que el anterior implementó y, se empiezan nuevos programas. En el país existe una carencia de políticas de Estado, regularmente se tienen políticas de gobierno que son permanentemente sustituidas por otras, no necesariamente mejores.  A 15 años de funcionamiento se han graduado de la universidad 37,129 a nivel y en el grado de licenciatura en educación pre primaria y primaria 7039, así como 480 en el nivel medio.
Formación de agricultores y diálogo entre las culturas: estudio de caso de la ecología y tecnología del olivo
Authors: Medina Rivilla Antonio , Medina Domínguez María C. , Medina Domínguez Concepción J.
Published: December 2024

Objetivo: desarrollar un modelo de profesionalización de agricultores con énfasis en el cultivo, cuidado y ecología del olivo y aceite, desde un enfoque de encuentro entre las culturas de Bailén (mediterránea) y Villa de Leyva (tropical).
Originalidad/aporte: la singular innovación e investigación formativa, que armoniza la profesionalización de los agricultores en una nueva ecología y economía sustentables, con apoyo de la tecnología drónica.
Método: el método empleado es el mixto, puesto que el proceso de investigación desde la complementariedad, pero con singular profundización en el estudio de caso y narrativas autobiográficas de agricultores innovadores.
Estrategias de recolección de información: diseñamos instrumentos y nos focalizamos en el estudio de caso de agricultores en Bailén y Comarca, complementados con diálogos y encuentros culturales en explotaciones agrarias y análisis de la visión olivarera en Villa de Leyva y Comarca.
Conclusión: se ha generado un modelo teórico-práctico de profesionalización de agricultores basado en el conocimiento de la cultura olivarera, la aplicación de la tecnología drónica, el desarrollo de organizaciones cooperativas y el compromiso con una nueva ecología y ética para el desarrollo y valoración de la historia y parajes olivareros, que ha incidido en una nueva salutogénesis.
A 19. SZÁZADI BŰNÜGYI TÖRTÉNET ÉS „BŰNREGÉNY” 21. SZÁZADI REKONSTRUKCIÓI
Authors: BENCE Erika , ISPÁNOVICS CSAPÓ Julianna
Published: December 2024

Milbacher Róbert Léleknyavalyák – avagy az öngyilkolás s egyéb elveszejtő szerek természetéről című 2018-as, illetve András László A vörös korona: Mindenkiből lehet áldozat című 2021-ben napvilágot látott bűnregénye is reflektál a 19. századi magyar bűnügyi történet létformájára, pontosabban a hiányára. Az előbbi önfi a Fanni hagyományaitól a Testvériség- trilógián át a Pokolkerékig működtetett eljáráson alapul: úgy határozza meg saját helyét az alakulástörténetben, mintha egy hiányzó, elveszett vagy elfelejtett mű(faj) utólagos rekonstrukciója volna. András László regényében viszont a főhős, Harmath Endre nyomozó beszél a 19. századi bűnesetek természetéről, különösen az 1880-as évek e téren tapasztalt jelenségeiről, amelyeknek – állítása szerint – leghitelesebb ábrázolását Lengyel Péter Macskakő (1988) című regénye jelenti. Mindezek a refl azt sugallhatják számunkra, hogy a 19. századi magyar irodalomban, mert – a Lengyel által megjelenített millennium időszakát kivéve – Magyarországon nem történtek „ötletes”, nagy volumenű vagyszürreális bűnesetek (mint például a Morgue utcai kettős gyilkosság), maga a műfajtípus is hiányzik a magyar irodalom vonatkozó korszakának reprezentációjából, ezért – mint Milbacher a Léleknyavalyákkal – utólagosan kell létrehozni. Jelen kutatás célja, hogy megvizsgálja, feltérképezze és bemutassa, ha mégis létezett a műfajtípus, hogyan, milyen formában volt jelen a 19. századi magyar irodalomban, és miképp hagyományozódott tovább a 20. vagy a 21. századi bűnregényben.
A MAGYAR ÉS A HORVÁT NÉPCSOPORT A BURGENLANDI REGIONÁLIS IRODALOMBAN
Authors: ERLINGHAGEN Erika
Published: December 2024

A kelet-ausztriai Burgenlandban három őshonos, az állam által elismert kisebbség él: a magyar, a horvát, valamint a roma népcsoport. Bár ezen népcsoportok mindegyike saját szépirodalommal rendelkezik, a nagyközönség számára ez kevésbé ismert, mivel elenyésző és tematikailag eléggé specifikus. Ugyanakkor a régió német nyelvű irodalma, amely sokkal szélesebb közönséghez jut el, gyakorta megjeleníti és tematizálja ezeket a népcsoportokat, kultúrájukat, nyelvüket. A tanulmányban négy regény kerül összehasonlításra, melyekben a burgenlandi magyar vagy a horvát népcsoport szerepel. Ezáltal láthatóvá válnak a különféle irodalmi reprezentációk, a klisékkel való bánásmódok és a többségi társadalomban létező képek a két népcsoportról.
YUGOSLAVIA AND THE POLICY OF NON-ALIGNMENT IN THE SECOND HALF OF THE 1960S
Authors: NOVOSELTSEV Boris S.
Published: December 2024

Based on material from the Archives of Yugoslavia (Belgrade, Serbia) as well as a number of international documents and analytical papers published in English on the Internet, the artic- le attempts to analyse the development of the policy of non-alignment in the second half of the 1960s, the role Yugoslavia and personally President Josip Broz Tito played in it, and the ways to extricate the Non-Aligned Movement from crisis. The initiatives to hold an interna- tional summit dedicated to cooperation between the countries of Asia, Africa, and some other regions of the world and the reasons for the success of the Yugoslav-Indian concept of non-alignment are explored in broad international context. Consideration is given to the prepa- ration of the Lusaka conference; the range of issues under discussion; the structure of the permanent institutions of the Non-Aligned Movement that emerged at the summit; the impact of decisions made on the further development of the Non-Aligned Movement in the 1970s.
AZ EMBERTELENSÉG KONSTANCIÁJA KÖRVONALAKBAN
Authors: TURBUCZ Péter
Published: December 2024

Barcsi Tamás. 2023. Embertelenség az együttérzés korában: Filozófiai vázlat a kegyetlenségről. Máriabesnyő: Attraktor Kiadó.
ÓVODA-ISKOLA ÁTMENETET MEGKÖNNYÍTŐ PROGRAMOK
Authors: BENCÉNÉ FEKETE Anikó Andrea
Published: December 2024

Az iskolának az az elsődleges feladata, hogy minden gyermeket hozzásegítsen, egyéni képességeinek megfelelően az életben történő boldoguláshoz (Mesterházi 1999). Az óvodások, amikor átlépik az iskola kapuját, számukra ismeretlen környezetbe kerülnek, szigorú szabályrendszerhez kell alkalmazkodniuk (Golyán 2017). A változás hatására a gyermekek sérülékenyebbek lesznek érzelmi és pedagógiai szempontból (Fabian 2007). Empirikus kutatásunk célja annak feltárása, hogy a tanítók milyen módszereket alkalmaznak Magyarországon a gyengéd átmenet megteremtésének érdekében. Kutatási kérdéseink arra irányultak, hogy van-e különbség a falusi és a városi iskolában alkalmazott módszerek között, szükség van-e a tanévkezdést megelőző foglalkozásokra. A 2022/23-as tanévben mélyinterjút készítettünk tíz elsős tanítóval, ezt követően válaszaik alapján összehasonlító elemzést végeztünk. Az eredmények azt mutatták, hogy a falvakban a gyerekek sokkal könnyebben veszik az akadályokat, mert az óvodás csoport alkotja az első osztályt. A városban az óvodás csoport szétszakad, mert nem azonos iskolában folytatják a gyerekek tanulmányaikat, így még hangsúlyosabb szerepe van az iskolát megelőző foglalkozásoknak.
Integrated Bioinformatic Approach for Precision Medicine: Prediction of Human GABRG2 Gene Pathogenic Variants, Characterized with Cellular Pathology and Epilepsy Phenotype Severity
Authors: Khudhair Abdullah Nabaa , Arslan Ayla
Published: December 2024

Interpreting GABRG2 variants of unknown significance hinders epilepsy precision medicine. Using computer algorithms, our study focused on 156 GABRG2 variants from ClinVar, identifying 10 highly pathogenic variants within the γ2 subunit. Integration with patient mutations and mutagenesis studies locates variants within epileptogenic structural cassettes, aiding phenotype severity and cellular pathology characterization. Our results predict milder phenotypes for 3 N-terminus extracellular domain variants and more severe phenotypes for 7 transmembrane domain variants, linked to cellular pathology with reduced cell surface expression and current. Notably, 4 transmembrane domain variants may distort channel conductance. Our research aligns with ACMG/AMP criteria PP3 and PM1.
Türkiye'nin Üç Pilot İlinde Çığ Tehlike ve Risk Analizleri: Bitlis, Van ve Antalya Örnekleri
Authors: Yıldız Engin , Selek Zeliha
Published: December 2024

Çığ, orman örtüsünün olmadığı veya seyrek olduğu dağların eğimli yüzeylerinde birikmiş kar tabakasının çeşitli nedenlerle dengesini kaybederek yerçekimi etkisiyle harekete geçmesi olarak tanımlanmakta ve tahmin edilemeyen büyük can ve mal kayıplarına yol açmaktadır. Türkiye'nin topografik ve iklimsel özellikleri bakımından Bitlis, Van ve Antalya bölgelerinde, yerleşim yerleri, karayolları, kayak merkezleri ve dağlık alanlarda planlanan tesisler için çığ ciddi bir tehdit oluşturmaktadır. Bu çalışmada, 3 pilot bölgede arazi incelemeleri yapılmış ve çığ riski bulunan bölgeler hakkında yerel halktan bilgiler edinilmiştir. Daha sonra bu pilot bölgeler için çığ başlama bölgeleri, RAMMS yazılımı ile 2 boyutlu çığ simülasyonları, çığ tehlike haritaları, risk analizleri ve riskinin azaltılmasına yönelik önceliklendirmeler yapılmıştır. Önceliklendirmelere göre belirlenen riskli bölgelerde çığ risk azaltma yöntemleri önerilmiştir. Bu çalışma, mevcut ve ileri dönemli yerleşim, karayolu, turizm tesisleri vb. yapıların planlamalarında çığ tehlike haritalarının kullanımının önemini vurgulamakta, kalitatif ve kantitatif risk analizleri gerçekleştirerek çığ afetinin daha iyi anlaşılmasına katkı sağlamaktadır.
Yapı Zemin Etkileşiminin Yığma Bir Minarenin Sismik Davranışına Etkisi
Authors: Şakalak Elifnur , Sever Ali Ekber , Usta Pınar
Published: December 2024

Zemin ile üst yapının geometrik, mekanik ve dinamik özellikleri birbirlerine aktarıldığı için tasarımları bağımsız düşünülmemelidir. Yapı zemin etkileşimi göz önüne alınarak gerçekleştirilen analizlerde yapı periyodu ve periyoda bağlı olarak etki eden yatay kuvvetler zemin özelliklerine göre değişiklik gösterir. Bu çalışmada yapı-zemin etkileşiminin yığma bir minarenin sismik davranışına etkisi araştırılmıştır. Bu amaçla Türkiye’nin Isparta ilinde inşa edildiği düşünülen tipik bir yığma minare Sap2000 programında modellenmiştir. Yapı zemin etkileşiminin minarenin sismik davranışına etkilerini görmek için minarenin, zemine ankastre mesnetli (FS) ve yapı zemin etkileşimli (SSI) iki ayrı sonlu eleman modeli oluşturulmuştur. İki model üzerinde, 2018 Türkiye Bina Deprem Yönetmeliğine uygun modal analiz, tepki spektrumu analizi ve zaman tanım alanında analiz gerçekleştirilmiştir. Zaman tanım alanında analiz için son dönemde meydana gelen Türkiye’de asrın felaketi olarak adlandırılan Pazarcık Depremi, Elbistan Depremi ve Hatay Depremi’nin ivme kayıtları kullanılmıştır. Yapılan analizler sonucunda elde edilen veriler ile yapı zemin etkileşimli ve ankastre mesnetli modellerin sonuçları karşılaştırılmıştır. Modal analiz sonucunda SSI modelin periyot değerinin daha yüksek olduğu belirlenmiştir. Zaman tanım alanında yapılan analizler sonucunda, yapının tepe noktasındaki en büyük yatay yer değiştirme değerleri karşılaştırıldığı zaman SSI modelde daha büyük yer değiştirmelerin olduğu tespit edilmiştir. En büyük asal gerilmeler karşılaştırıldığında SSI modelde FS modele nazaran daha yüksek gerilmelerin oluştuğu tespit edilmiştir.
Şıkıştırılmış Kil Zeminlerin Şişme Basıncının Belirlenmesinde Bulanık Mantık Yaklaşımı
Authors: Çimen Ömür , Keskin Nilay
Published: December 2024

Bu çalışmada kil zeminlerde önemli bir mühendislik problemi olan şişme basıncının belirlenmesinde bulanık mantık kuralları kullanılmıştır. Bu amaçla kilin şişme basıncını etkileyen parametrelerden olan plastisite indisi, başlangıç su muhtevası ve kuru birim hacim ağırlık değerleri dikkate alınmıştır. Öncelikle şişme basıncı ve etki eden parametreler bulanık alt kümelere ayrılmıştır. Bulanık kural tabanı oluşturulmuş ve Fortran dilinde programlanmıştır. Daha sonra şişme potansiyeli yüksek olan üç kil numunesi üzerinde sabit hacimli şişme deneyleri yapılmıştır. Şişme deneyleri için altı farklı başlangıç su muhtevası ve yedi farklı kuru birim hacim ağırlıkta numuneler kompaksiyonla hazırlanmıştır. Deneyden elde edilen şişme basıncı değerleri ile bulanık mantık modelinden elde edilen değerler karşılaştırılmıştır. Şişme basıncının 40 kPa ‘ın üzerinde olduğu durumlarda, bulanık mantık modelinden elde edilen şişme basınçları ile deneysel sonuçlar arasındaki maksimum hata miktarı %10 dolaylarındayken, daha düşük şişme basıncı değerlerinde maksimum hata miktarının %30 ‘un üzerine çıktığı görülmüştür. Şişme basıncı tahmininde ortalama hata miktarı ise %9.73 olarak elde edilmiştir.
Çok Katmanlı Gömülü Arkeolojik Kalıntıların Araştırılmasında Jeofizik Elektrik Özdirenç Yöntemi: Aydın Küçüktepe Höyük Örneği
Authors: Karaaslan Hasan
Published: December 2024

Tahribatsız olarak sahada uygulanabilen jeofizik yöntemler ve özellikle elektrik özdirenç yöntemi, arkeolojik alanların araştırılmasında yüksek çözünürlüklü çözüm üreten tekniklere ve kanıtlanmış etkinliğe sahiptir. Bu makale, jeofizik veriler kullanılarak büyük bir Höyük alanında gömülü yapıların araştırılmasına dair bir örnek sunmaktadır. Yeraltının özdirenç dağılımı, paralel hatlar boyunca elde edilen 29 ERT verisini kullanan iki boyutlu ve üç boyutlu ters-çözüm işlemleriyle analiz edildi. Wenner elektrot dizilimi toplanan ERT profillerinin analizi ile elde edilen yeraltı özdirenç modeli, 3-Boyutlu derinlik kesitleri ile görselleştirilmiştir. Belirlenen özdirenç karakterleri yüzeyde ve daha derinde olmak üzere Aydın Küçüktepe Höyük alanında katmanlı bir yapı stratigrafisine dair bulguları ortaya çıkarmıştır. Çalışma sonuçları, jeofizik yöntemlerin arkeolojik kazı alanlarında kullanımının, yorumlama belirsizliklerini ve olası hataları etkili bir şekilde azalttığını ve çok daha iyi yeraltı karakterizasyonu sağladığını göstermiştir.
Novel Trifluoromethyl Containing Azo-Imin compounds: Synthesis, Characterization, and Investigation of Antioxidant Properties Using In Vitro and In Silico methods
Authors: Yeşil Tolga Acar
Published: December 2024

Abstract: In this study, two new molecules 4-((4-methoxyphenyl)diazenyl)-2-(((4-(trifluoromethyl)phenyl)imino)methyl)phenol (3a) and 2-(((4-methoxyphenyl)imino)methyl)-4-((4-(trifluoromethyl)phenyl)diazenyl)phenol (3b) were synthesized. The 1H-NMR, FTIR, UV-vis, and Mass analysis techniques were used to confirm the structures of the 3a and 3b. CUPRAC in vitro antioxidant activity method was also used to investigate the antioxidant properties of synthesized compounds. The compounds' ADME and toxicity parameters were also computed using SwissADME, Protox-II web servers respectively. In silico Molecular docking studies were conducted utilizing four different antioxidant proteins, such as PDB ID: 1N8Q for Lipoxygenase, 1OG5 for CYP2C9, 2CDU for NADPH oxidase, and 4JK4 for Bovine Serum Albumin, to investigate the potential antioxidant properties of the synthesized compounds 3a and 3b. ADME and toxicity (ADMEt) results showed that pharmacokinetic, physico-chemical, drug-similarity, and toxicity data were all appropriate for a potential bioactive agent. Molecular docking results have shown that all docking results were higher than standard (Trolox). The best docking score (-9.4 kcal/mol) was between 3b ligand and 2CDU protein. TEAC values of compounds were also higher than standard which was in harmony with molecular docking scores. From all obtained data It was concluded that the compound 3b has the potential antioxidant agent.
Delineation of the Subsurface Structures in the Central Sumatra Basin (Indonesia) through Bouguer Gravity Data
Authors: Erbek-kıran Ezgi , Nadjib Fahmi Ainun
Published: December 2024

This study presents the delineation of the boundaries of the subsurface structures located in the eastern part of the central Sumatra basin using Bouguer gravity data. The existence of the high gravity anomalies in the eastern part displayed in this sedimentary basin takes attention. Therefore, investigation of the reason for these high anomalies is required for the region. To this end, gravity anomalies have been processed by advanced potential field methods such as the power spectrum analysis method and tilt method. The average depths of the deep and shallow causative sources have been calculated as 23.71 km and 1.61 km, respectively. Furthermore, the boundaries of the causative sources have been determined utilizing the tilt method. The tilt map has shown that the reason for these high anomalies could be the bedrock composed of high-density material rising upwards, considering the tectonic background of the region. This study has determined that this high structure is in the form of a triple structure and that its upper depths are approximately 5.8 km, 11.30 km, and 12.8 km from north to south, respectively. As a result, it could be said that such sources with deep roots could be prospective for hydrocarbon maturation.
Possibilities of analyzing the network connectivity of ideological and monothematic radical online communities on VKontakte
Authors: Kashpur Vitaliy , Baryshev Alexey , Serbina Galina , Gubanov Alexander , Demeshkin Ilya
Published: December 2024

The article discusses the possibilities of applying social network analysis methods to search for network connectivity of audiences of single-issue (anti-vaxxer, eco-radical, antinuker) and ideological (radical Islamist, left-wing and right-wing) radical online communities of the VKontakte social network. To determine the network connectivity between online communities of ideological and single-issue radicals using a dictionary of linguistic markers, an automatic search and selection of communities was performed by screening the selected units. Then, a weighted graph of connections was constructed and analysed. In the graph, the nodes are communities, and the edges connect communities that have at least one common subscriber. The analysis of the following metrics is illustrative: weighted degree, degree centrality, and weighted betweenness centrality. To assess the strength of connections between single-issue communities and communities of ideological radicals, the degree of assortativity was measured by compiling a matrix that describes the assortativity of communities by their type. It is shown that, despite the communities’ different sizes and information activity, this approach makes it possible to assess their network connectivity.
Review of sociological databases on consumption
Authors: Lebedeva Daria
Published: December 2024

The article suggests a typology of sociological sample surveys on consumption. A detailed classification of 106 databases is given according to their geography, time frame, institutional affiliation, access to data, sampling and data collection methodology, and thematic content. Among databases reviewed, six main types of surveys were distinguished: 1) Household Economic Survey; 2) Marketing consumer surveys; 3) Consumer sentiment indices; 4) Surveys of household time budgets; 5) Single studies in the field of consumption; 6) Repositories of quantitative and qualitative data in the field of consumption. The identified types are described by the following characteristics: topics covered by the surveys, institutional affiliation, type of sampling and data collection, mode of access, possibilities for enrichment with other types of data, advantages and disadvantages when used by academic researchers. The online appendix offers a complete navigator table for the surveys included in the review.
El bien común como promesa de universidad. El caso dominico en Chile durante la primera parte del siglo XVII
Authors: Ochoa-Arias Alejandro , Lara Coronado Jesús
Published: December 2024

El siguiente artículo tiene como propósito reflexionar y analizar respecto de un concepto-idea, el bien común, que pareciera ser actual y que ha tomado fuerza en el presente desde el punto de vista de la igualdad y equidad. No obstante, cuando se estudia su trayectoria conceptual para el caso chileno, específicamente la referida al ámbito de la creación de la primera universidad fundada en Chile (siglo XVII), ya se puede observar que el uso del bien común estaba relacionado con cuestiones geográficas, económicas, educativas, sociales e incluso jurídicas, las cuales tenían como finalidad ser un beneficio para los vecinos y moradores de la época. Por este motivo, este estudio se centra en entender y analizar, desde una mirada interdisciplinaria, por un lado la historia conceptual y, por otro, la sistémica interpretativa, para presentar los primeros hallazgos sobre la interpretación de la idea de bien común y su uso por parte de los dominicos para sustentar el permiso para crear la universidad en Chile.
El Colegio Mayor de San Bartolomé y Santiago. Medio siglo de enseñanza en Granada (1909-1965)
Authors: Carrillo Juan L.
Published: December 2024

En el presente trabajo se aborda la historia de esta institución y sus transformaciones en el periodo que va de 1909 a 1965, en la que pasó de ser un colegio privado de segunda enseñanza adscrito al Instituto General y Técnico de Granada a una residencia universitaria. Si dirigimos muestra mirada a la superestructura política y religiosa, los reglamentos de 1909, 1928 y 1954, así como la arquitectura jurídica que los sustentaban, éstas nos hablan de su carácter confesional, pero todo esto matizado por las diferentes coyunturas político-sociales –periodo final de la Restauración, Dictadura de Primo de Rivera, Segunda República, Guerra Civil y franquismo– que no excluyen el talante personal de los diferentes rectores que se sucedieron a lo largo de medio siglo: Gómez Izquierdo (veinte años), Mérida (cinco), García (cuatro), Carrera (nueve, más veinte como vicerrector), Cabanelas (tres), Bernal (dos) y Blanco (tres).
El movimiento estudiantil antifranquista. Un terreno fértil. El proceso de construcción de un ámbito historiográfico
Authors: Calvo Romero Sergio
Published: December 2024

El movimiento estudiantil antifranquista ha experimentado una evolu­ción historiográfica extraordinaria, pasando de ser una mera lista cronológica de hechos a pequeñas disertaciones, hasta llegar a con­vertirse en un campo de análisis con entidad propia, un ámbito historiográfico prolífico y crucial para entender el complejo proceso de movilización social que se inició mediados de los años sesenta. Desde las primeras obras de los años setenta, década tras década han se ha ido consolidando una escuela de historiado­res que han ido arrojando luz sobre muchos de los vacíos historiográficos que existían, y lo que es más importante, han dado respues­tas a muchos de los interrogantes que se iban planteando.
Mouse models of primary sclerosing cholangitis: we just can’t get enough
Authors: Arechederra Maria , Fernandez-Barrena Maite G. , Berasain Carmen , Avila Matias A.
Published: December 2024

Primary sclerosing cholangitis (PSC) is a rare but devastating disease affecting the intra- and extrahepatic bile ducts, frequently progressing to end-stage liver disease. Patients develop peribiliary inflammation and fibrosis, leading to multifocal biliary strictures that evolve to biliary cirrhosis. PSC is frequently associated with inflammatory bowel disease and a high risk of cholangiocarcinoma development. The pathogenesis of this disease is not completely understood, and currently, there are no effective therapies beyond liver transplantation. The available experimental models of PSC do not fully reproduce the phenotype of the disease, and this is a major limitation for unraveling its pathogenic mechanisms and evaluating novel therapies. A recent study by Lukasova et al. proposed a new hypothesis on the pathogenesis of PSC. The relevance of their work is two-fold: (1) the authors provide preliminary evidence suggesting that the disruption of tight junctions in mouse biliary epithelium leads to a PSC-like phenotype; and (2) they provide the research community with a novel transgenic mouse model of the disease. Follow-up studies on this new mouse model are eagerly awaited.
Review of Lagrangian formalism in biology: recent advances and perspectives
Authors: Pham Diana T. , Musielak Zdzislaw E.
Published: December 2024

The Lagrangian formalism has attracted the attention of mathematicians and physicists for more than 250 years because of its significant roles in establishing modern theoretical physics. The history of the Lagrangian formalism in biology is much shorter, spanning only the last 50 years. In this article, a broad review of the Lagrangian formalism in biology is presented in the context of both its historical and modern developments. Detailed descriptions of different methods to derive Lagrangians for five selected population dynamics models are given, and the resulting Lagrangians are presented and discussed. The procedure to use the obtained Lagrangians to gain new biological insights into the evolution of the populations without solving the equations of motion is described and applied to the models. Finally, perspectives of the Lagrangian formalism in biology are discussed.
Effective Models of QCD and Their Implications for Dark Matter Phenomenology
Authors: Singh Swapnil
Published: December 2024

This paper investigates the implications of effective Quantum Chromodynamics (QCD) models for dark matter phenomenology, with a particular focus on the role of QCD phase transitions, topological defects, and low-energy effective models in understanding dark matter's nature and behavior. We begin by analyzing the formation and thermodynamic properties of the quark-gluon plasma (QGP) in the early Universe, emphasizing the speed of sound \( c_s^2 \) and its effects on primordial density fluctuations, which are crucial for the formation of large-scale structures. The thermodynamic relation \( c_s^2 = \frac{\partial p}{\partial \epsilon} \) is used to model the impact of these fluctuations on the evolution of the Universe. Topological structures arising from scale symmetry breaking during the rapid cooling phase of the early Universe, are explored as potential candidates for dark matter. These structures are shown to bridge the gap between QCD and cosmology, providing insights into the dark matter sector and predicting the presence of axions or other relic particles that could contribute to dark matter's observed properties. The paper also presents an in-depth study of Skyrme solitons and their potential to act as dark matter analogues. We examine the clustering dynamics of Skyrme solitons within dark matter halos, revealing a significant dependence of the soliton's energy density and stability on soliton number \( N \) and dark matter density \( \rho_{\text{DM}} \). Numerical simulations show a strong increase in system energy as both \( N \) and \( \rho_{\text{DM}} \) are increased, highlighting the role of solitons in dark matter clustering and the formation of cosmological structures. The dynamical mass \( M(T) \) of scalar fields in the presence of gravitational couplings and chemical potentials is analyzed, showing clear dependencies on the scalar field mass \( m_0 \), temperature \( T \), and gravitational coupling \( G \). The findings indicate that variations in the chemical potential \( \mu \) lead to significant changes in mass distribution, corroborating predictions from quantum field theory (QFT) and cosmological models. Further, Chiral Perturbation Theory (ChPT) is extended to the dark sector, where SU(N) symmetries govern dark matter interactions. This extension reveals new annihilation channels for dark matter and links dark sector dynamics with cosmological observables, such as the cosmic microwave background (CMB) and dark matter relic abundance. The effect of ChPT on dark matter perturbations and large-scale structure formation is analyzed, emphasizing the role of higher-order corrections to scattering amplitudes and cross-sections in shaping the evolution of dark matter.
Targeted Metagenomic Analysis as a Clinical Tool for the Investigation of the Impact of Bundle of Interventions on the Burden of Resistance Genes Among Severely Ill Pediatric Patients
Authors: Giampani Athina , Simitsopoulou Maria , Sdougka Maria , Roilides Emmanuel , Iosifidis Elias
Published: December 2024

Background: Antimicrobial drug resistance is recognized as one of the most important global public health threats. There is an urgent need to reduce the spread of the multidrug-resistant bacteria (MDR-B) bacteria, particularly in clinically extremely vulnerable patients. The aim of this study was to investigate whether targeted gene amplification directly on clinical samples can be used as a rapid and effective tool for active surveillance of antimicrobial resistance in a Pediatric Intensive Care Unit (PICU). Methods: The study had three phases: 1) The Baseline phase performed prior to intervention, when first screening and sample collection was performed, 2) the Intervention phase, when a bundle of enhanced infection control measures (EICM) was applied, and 3) the Maintenance phase when enhanced infection control measures were combined with the implementation of the targeted molecular surveillance. The presence of four carbapenemases: blaKPC, blaOXA-48-like, blaVIM, and blaNDM as well as of blaTEM and blaSHV were evaluated by PCR after DNA isolation directly from stool samples. Results were compared to culture-based phenotypic analysis. Results and Conclusions: The applied EICM led to decreased colonization of blaKPC, blaVIM and blaTEM . Implementation of EICM has been shown that it may reduce the resistance burden in this clinical setting endemic to MDR-B. Direct implementation of a targeted and customized rapid molecular detection assay to clinical samples seems to be an effective clinical tool for the evaluation of antimicrobial stewardship measures.