bluuebunny/crossref_metadata_2025 huggingface dataset:
CENTRAL HYDATID CYST OF THE LIVER FISTULIZED IN THE BILE DUCTS, DIFFICULT SURGICAL ACCESS AND THE CONTRIBUTION OF ENDOSCOPYA STUDY OF THREE CASES
Authors:   Visceral Surgery Department II, Military Teaching Hospital Mohamed V, Morocco., Bourouail Othmane , Kada Ali ,   Visceral Surgery Department II, Military Teaching Hospital Mohamed V, Morocco., Ballouch Mohamed ,   Visceral Surgery Department II, Military Teaching Hospital Mohamed V, Morocco., Rahali Anouar ,   Visceral Surgery Department II, Military Teaching Hospital Mohamed V, Morocco., Halim Mustapha ,   Visceral Surgery Department II, Military Teaching Hospital Mohamed V, Morocco., Elfadili Aziz ,   Visceral Surgery Department II, Military Teaching Hospital Mohamed V, Morocco., Njoumi Noureddine ,   Visceral Surgery Department II, Military Teaching Hospital Mohamed V, Morocco., Fahssi Mohamed ,   Visceral Surgery Department II, Military Teaching Hospital Mohamed V, Morocco., Yaka Mbarek ,   Visceral Surgery Department II, Military Teaching Hospital Mohamed V, Morocco., Hejjouji Abderrahmane ,   Visceral Surgery Department II, Military Teaching Hospital Mohamed V, Morocco., Ait Ali Abdelmounaim ,   Visceral Surgery Department II, Military Teaching Hospital Mohamed V, Morocco.
Published: May 2023

Hepatic hydatid cyst is one of the common public health problems in Maghreb, remains a benign pathology, but its seriousness concerns its complications, which are largely dominated by cystic rupture in the bile ducts.The aim of this study is to highlight the difficulty of surgical treatment of hydatic cyst, localized in central part of liver and ruptured in biliary ducts with the place of endoscopywe report the cases of three patients with central hepatic hydatid cyst opening in biliary ducts which are treated differently by surgery and endoscopy. Results: The surgery with the radical and conservative treatment in compared to endoscopy procedure was technically more difficult and efficient, but at the expense of morbidities and a longer hospitalization period. Conclusion: Cysto-biliary fistula is the most frequent and the most frightening complication of liver hydatid cyst, the surgery is the gold standard treatment with the conservative and radical methods. however, some locations such as central part of liver make surgery very difficult and dangerous which open the topic of the usefulness of the endoscopy in this problem.
TAKOTSUBO CARDIOMYOPATHY (STRESS CARDIOMYOPATHY) INDUCED BY COVIDINFECTION: A CASE REPORT
Authors:   Cardiology Department, Hatta Hospital, United Arab Emirates., Hasan Khaiyo Mammon , Mahmoud Ibrahim Mohamed Mohamed ,   Internal medicine/Gastroenterology, Hatta Hospital, United Arab Emirates., Abdulmola Albawab Amer ,   Cardiology Department, Hatta Hospital, United Arab Emirates., Muhamed Al Meselmani Hazem ,   Cardiology Department, Hatta Hospital, United Arab Emirates., Khaled Abou El Foul Rami ,   Internal medicine/Gastroenterology, Hatta Hospital, United Arab Emirates., Alaqqad Mohamed ,   Surgery Department, Hatta, United Arab Emirates.
Published: May 2023

Stress cardiomyopathy (also called apical ballooning syndrome, takotsubo cardiomyopathy, broken heart syndrome, and stress-induced cardiomyopathy) is a syndrome characterized by transient regional systolic dysfunction, principally, of the left ventricle (LV), mimicking myocardial infarction (MI), but in the absence of angiographic evidence of obstructive coronary artery disease or acute plaque rupture. In most cases of stress cardiomyopathy, the regional wall motion abnormality extends beyond the territory perfused by a single epicardial coronary artery. The term takotsubo is taken from the Japanese name for an octopus trap, which has a shape that is similar to the systolic apical ballooning appearance of the LV in the most common and typical form of this disorde mid and apical segments of the LV are hypokinetic/akinetic, and there is hyperkinesis of the basal walls.
ARTICULATING THE GENDERED WOMAN SUBJECT THROUGH ALTER NARRATIVES OF DRAUPADI: A COMPARATIVE READING OF PRATHIBHA RAYS YAGNASENI AND CHITRA BANERJEE DIVAKARUNISTHE PALACE OF ILLUSIONS
Authors:   Assistant Professor GLSBBA Institute, Faculty of Business Administration, GLS University., Janardhanan Prathyaksh
Published: May 2023

Gender as a conceptual and epistemological category for sociological and academic debate has always spurred contestable narratives, which might not be binary in nature. The fact that the category continues to spark the ashes of resistance in itself is a testimony for the need to further these debates and discussions. Indian epics, which are the repository of stories, due to its genre based palimpsest narratives culminate in the silencing of vital voices from within the macro narratives of the text. Further since epics have predominantly focused on the exploits of men. Women charecters in the epics are relegated to the role of the muse and the source of inspiration and strength for the hero. The character of Draupadi is an aberration in this sense of articulation. While her portrayal in the epic has been along the lines of a self-willed, headstrong woman who dragged an entire illustrious race to the decadence of war and annihilation, several character based rewritings of the epic have attempted to create alternative narratives or alter narratives to contest the biased patriarchal macro narratives which attempt to frame Draupadi as the reason for the genocide of a race. This paper offers a comparative reading of several rewritings and works on Draupadi with specific focus on Prathibha Rays Yagnaseni and Chitra Banerjee Divakarunis The Palace of Illusions to argue how alternative narratives as showcased in these novels help articulate a new alter narrative voice for the gendered subject, through which she is enabled the agency to create new narratives of resistance to combat the macro epistemic narratives created by the larger framework of a patriarchal ecosystem.
A DEEP NEURAL NETWORK FOR BODY PART-BASED CEREBRAL PALSY PREDICTION IN INFANTS TO DETECT ABNORMAL MOVEMENTS
Authors:   Undergraduate(Final Year), Department of Information Technology, Kongu Engineering College, Tamil Nadu, India., C.V Akshayanivashini , S.C Karthikraj ,   Undergraduate(Final Year), Department of Information Technology, Kongu Engineering College, Tamil Nadu, India., R. Anand ,   Undergraduate(Final Year), Department of Information Technology, Kongu Engineering College, Tamil Nadu, India., N. Anitha ,   Associate Professor, Department of Information Technology, Kongu Engineering College, Tamil Nadu, India.
Published: May 2023

Cerebral palsy is a neurological disorder that can be diagnosed as early as infancy. Early diagnosis and intervention can significantly improve outcomes for infants with cerebral palsy. In this study, we propose a method for predicting cerebral palsy in infants using pose-based feature sets and velocity information, and compare its performance with a Convolutional Neural Network (CNN) approach.A reliable dataset containing pose-based feature sets and velocity information related to the limbs of infants is collected and pre-processed by handling missing values, normalizing the feature sets and velocity information, and splitting the data into training and testing sets. Relevant features, such as joint orientations, displacements, and velocities in the X and Y directions, are extracted from the pose-based feature sets and velocity information.An MLP algorithm is trained using the preprocessed and normalized feature sets as inputs and the corresponding cerebral palsy diagnosis as the target output. Supervised learning is used to optimize the models parameters and weights. The performance of the trained MLP model is evaluated using various evaluation metrics, and the results show high accuracy in predicting cerebral palsy in infants.Next, a CNN approach is implemented for comparison. The pose-based feature sets and velocity information are used to train the CNN model, which consists of convolutional layers for feature extraction and pooling layers for spatial downsampling. The output from the CNN model is then fed into fully connected layers for classification. The performance of the CNN model is also evaluated using the same evaluation metrics as the MLP model.The results of the comparative analysis show that the MLP model achieves high accuracy in predicting cerebral palsy in infants, outperforming the CNN model. The MLP models accuracy compared to the CNN model. The interpretations of the MLP models predictions are validated using additional validation datasets or by comparing with existing diagnostic methods for cerebral palsy.
Local antibacterial therapy in patients with diseases of the nasal cavity and paranasal sinuses, including against the background of cystic fibrosis
Authors: Sinkov E. V. , Nikiforova G. N. , Kozlova L. A.
Published: May 2023

Acute respiratory viral infection is one of the most common infectious diseases. Clinical manifestations vary from time to time and from person to person and, as a rule, include intoxication and catarrhal syndromes. ARVI is more often caused by such causative agents as pneumoviruses, human metapneumovirus, coronaviruses, rhinoviruses, adenoviruses and bocaviruses. Among diseases of the ENT organs, ARVI can cause rhinosinusitis and pharyngitis. The inflammation that occurs in the mucosa causes its dystrophy and necrosis, which leads to the dysfunction of mucociliary clearance. As a result, an optimal environment for the development of bacterial flora is created. Bacterial rhinosinusitis needs antibiotic therapy. These drugs can act locally and systemically. It is well known that topical drugs have fewer side effects and result in a greater active substance concentration directly at a site of inflammation. Currently, a nasal framycetin spray is used as a topical antibacterial therapy to treat bacterial rhinosinusitis and in the early postoperative period. Topical drugs have a good evidence base, fewer side effects, and are safe, even for patients with cystic fibrosis. Given the significant antibiotics load in patients with cystic fibrosis, any opportunity to delay re-administration of antibiotics is a positive thing. In this aspect, topical antibiotics that have no systemic adverse events, including negative effects on the normal human microbiome, and can be used to overcome the resistance of microorganisms in a varying degree due to the achievement of high active substance concentration directly in a focus of infection may have a certain therapeutic value. The article addresses issues of epidemiology, pathogenesis, clinical manifestations of acute respiratory viral infection, i. e. acute rhinosinusitis. In addition, the article describes the use of topical antibiotic therapy for the treatment of diseases of the nasal cavities and paranasal sinuses.
Modern methods of diagnosis and treatment of patients with COVID and post-COVID anosmia
Authors: Lebedeva G. V. , Morozova S. V. , Selezneva L. V. , Svistushkin M. V.
Published: May 2023

Since 2019, the interest in coronavirus infection has increased worldwide due to the emergence of several pandemic outbreaks associated with this group of pathogens. In total, 3 outbreaks of pandemics were registered in the 21st century, caused by new strains of coronaviruses: MERS-CoV, SARS-CoV and SARS-CoV-2. Among them the leader in prevalence, occurrence of severe respiratory complications and mortality is SARS-CoV-2. SARS-CoV-2 is the causative agent of the coronavirus disease of 2019. COVID-19 is a disease characterized by acute respiratory viral syndrome, transmitted by airborne droplets. The clinical course of COVID-19 varies significantly from patient to patient and can range from asymptomatic to severe forms. One of the common symptoms of the manifestation of COVID-19 is a smell disorder. The pathogenesis and clinical course of coronavirus infection caused by SARS-CoV-2 were examined to identify the causes leading to olfactory disorders in the manuscript. The analysis of existing methods for the diagnosis of olfactory disorders and their treatment was also carried out. The content of the article includes current hypotheses of the pathogenesis of viral anosmia in COVID-19 and a new look at the relevance of this problem among the population around the world. The article analyzes scientific data on the problem of anosmia in coronavirus infection caused by SARS-CoV-2, investigates modern diagnostic methods, highlights the principles of treatment of patients with post-COVID anosmia and presents prospects for further research on this problem.
Dupilumab in complex therapy for chronic rhinosinusitis with nasal polyps and asthma
Authors: Sivokhin D. A. , Shchennikova E. S. , Royuk V. V. , Kniajeskaia N. P.
Published: May 2023

Chronic Rhinosinusitis with Nasal Polyps (CRwNP) caused by T2 inflammation has a complex pathogenesis, for which treatment options include medical therapy (topical and systemic glucocorticosteroids, leuktriene inhibitors, etc.) and surgical therapy, often recurs and significantly reduces the quality of life for patients. Chronic rhinosinusitis with nasal polyps is common in patients with asthma and, particularly, severe asthma and an allergic reaction to nonsteroidal anti-inflammatory drugs. These conditions are in most cases associated with a common pathogenesis, including a type II immune response, hyperproduction of interleukins (IL) 4, 5 and 13, activation of eosinophils and tissue remodeling. Biological therapy which block the effect of IL-4, 5, 13 can significantly improve the condition of such patients. Dupilumab is a humanized IgG4 monoclonal antibody that targets the IL-4 receptor alpha chain (IL-4Rα), thereby blocking the action of IL-4 and IL-13. Currently, dupilumab is approved for asthma, CRwNP and atopic dermatitis. Dupilumab can reduce the number of exacerbations, treatment with systemic corticosteroids, improve the condition of the upper and lower respiratory tract and achieve an increase in FEV1 by 0.2–0.3 L, which leads to a significant control of these diseases. One of the topical issues is the choice of tactics choice of treatment tactics in patients with CRwNP, asthma and nasal septum deviation. This article presents a clinical case of a patient with severe asthma, CRwNP and deviated nasal septum receiving dupilumab for 4 months.
The Effect of the Double Loop Problem Solving Model on Problem Solving Ability and Critical Thinking Skills
Authors: Arsya Ghina Tsania , Wahidin Wahidin , Ali Mufti
Published: May 2023

Problem solving abilities and critical thinking skills are 21st century skills that need to be developed with efforts to apply innovative learning models, namely double loop problem solving model. This study aims to determine the effect of the double loop problem solving model on students' problem solving abilities and critical thinking skills. The research method uses a quasi experiment with a nonequivalent control group research design. Data collection techniques using pretest and posttest. The data is processed by conducting analysis prerequisite tests in the form of a normality test, homogeneity test while the hypothesis test uses the one way ANOVA and post hoc follow-up tests. Based on the results of the research, it can be concluded that there is an influence of the double loop problem solving learning model on the problem solving abilities and critical thinking skills of students on biodiversity material in class X MIPA SMAN 4 Tasikmalaya in the 2022/2023 academic year
Development of Science Learning E-Module Equipped with Game On Material Classification of Living Things for Grade VII Students
Authors: Sari Arneta , Muhartati Erda , Oprasmani Elfa , Putri Azza Nuzullah
Published: May 2023

This research is a research and development with the ADDIE model. In the media and material validation process carried out by lecturers and teachers using instruments in the form of questionnaires, to measure practicality by teachers and students using instruments in the form of questionnaires, and effectiveness for students was measured using learning outcomes instruments consisting of 20 questions. The results of media development in the form of e-modules, namely the results of the validation of material experts obtained 94%, the validation of media experts obtained 90% in very valid criteria. Then for the implementation results in the form of teacher practice results obtained 96.6%, student practice results obtained 96.91% on very practical features and student effectiveness results obtained at 0.71 including the high category calculated on the N-Gain formula and for classical mastery a proportion 93.10% is obtained with a very effective mixture. Based on the results of the research, it can be interpreted that the science learning e-module is equipped with a game about the classification of practical living things in terms of attractiveness, ease of use, material adjustment and effectiveness in terms of KKM achievement.
Development of N2O emission factors derived from nitrification of treated sewage water in rivers
Authors: Yamazaki Hiroshi , Kagamu Ayaka , Kezuka Kenta , Murano Akito , Ebie Yoshitaka
Published: May 2023

Because treated sewage water contains nitrogen compounds such as NH4-N and NO2+3-N, nitrous oxide (N2O) which is one of the greenhouse gases is generated by nitrification and denitrification reactions in rivers. This study aimed to develop a method for estimating the amount of N2O generated from the nitrification of residual N compounds in treated sewage water by subtracting the amount of residual N2O dissolved in the treated sewage water. A year-round field survey of dissolved N2O (D-N2O) in the treated sewage water and river water showed that nitrification proceeded in the downstream direction in the rivers following the discharge of the treated sewage water, thereby generating N2O. The deaeration rate of N2O dissolved in the river water was obtained from a laboratory experiment. The N2O emission factor that can be applied to in-river nitrification of NH4-N contained in the treated sewage water was calculated to be 0.0025 kgN2O-N kgNH4-N-1.
LIBRETTI D'OPERA FRA ITALIA E POLONIA
Authors: Della Corte Federico , Masi Leonardo , Tonello Elisabetta
Published: May 2023

Il libro è composto da tredici testi di note¬vole pregio sia per il lettore meno esperto che per gli specialisti dell’opera, e offre una molteplicità di punti di vista (culturale, let¬terario, storico, musicologico) su un oggetto di studio relativamente limitato – ma al con¬tempo complesso – come il libretto d’opera. Inoltre fornisce un contributo importante sia per lo studio teorico, che per quello stori¬co-culturale delle relazioni italo-polacche. - dr hab. Elżbieta Jamrozik, prof. UW
Discursos vacíos para oídos estancados: hacia una hermenéutica de la acción
Authors: Velásquez Camelo Edgar Enrique
Published: May 2023

El estado actual del discurso, como modalidad específica de la comunicación humana, ha perdido, en algunos escenarios políticos, religiosos y culturales, su vinculación efectiva con la realidad, es decir, ha quedado desprovisto de referentes existenciales que soporten la idealidad del discurso. Así las cosas, la vacuidad semántica del discurso humano se ha perpetrado en el estancamiento existencial del ser humano convirtiéndose en obstáculo de los procesos de transformación personal y social. Por tal motivo, se hace preponderante la necesidad de que la idealidad del discurso humano se haga real y efectiva en la persona interpelada por medio de la hermenéutica de la acción, de tal forma que los grandes sueños de la humanidad no queden solo fijados en la escritura, sino que logren incidir de manera efectiva en la vida de las personas que conforman el entramado social comunicativo del mundo actual.
Application of Platelet-Rich Plasma as a Stem Cell Treatment - an
Attempt to Clarify a Common Public Misconception
Authors: Fareez Ismail M. , Liew Fong Fong , Widera Darius , Mayeen Naiyareen Fareeza , Mawya Jannatul , Abu Kasim Noor Hayaty , Haque Nazmul
Published: May 2023

In recent years, there has been a significant increase in the practice of regenerative
medicine by health practitioners and direct-to-consumer businesses globally.
Among different tools of regenerative medicine, platelet-rich plasma (PRP) and
stem cell-based therapies have received considerable attention. The use of PRP, in
particular, has gained popularity due to its easy access, simple processing techniques,
and regenerative potential. However, it is important to address a common misconception
amongst the general public equating to PRP and stem cells due to the demonstrated
efficacy of PRP in treating musculoskeletal and dermatological disorders. Notably,
PRP promotes regeneration by providing growth factors or other paracrine factors only.
Therefore, it cannot replenish or replace the lost cells in conditions where a large
number of cells are required to regenerate tissues and/or organs. In such cases, cellbased
therapies are the preferred option. Additionally, other tools of regenerative medicine,
such as bioprinting, organoids, and mechanobiology also rely on stem cells for
their success. Hence, healthcare and commercial entities offering direct-to-customer
regenerative therapies should not mislead the public by claiming that the application of
PRP is a stem cell-based therapy. Furthermore, it is important for regulatory bodies to
strictly monitor these profit-driven entities to prevent them from providing unregulated
regenerative treatments and services that claim a broad variety of benefits with little
proof of efficacy, safety concerns, and obscure scientific justification.
Salivary Protein Biomarkers for Diagnosis of Oral Squamous Cell
Carcinoma
Authors: Navale Archana M. , Deshpande Atharva , Mistry Bini , Chauhan Premal , Bhagat Charansharan
Published: May 2023

OSCC (Oral Squamous Cell Carcinoma) is a major health challenge in many parts of the
world. It occurs most commonly in males and is associated with tobacco, pan, or areca nut consumption.
One of the major challenges associated with the management of OSCC is late diagnosis. As a
result, the treatment required is more aggressive, expensive, and has poor prognostic value. On the
other hand, early diagnosis of OSCC can be life-saving with less aggressive treatment and a better
prognosis.

:

A diagnostic method for early diagnosis of OSCC is greatly needed. A lot of research efforts have
been made to identify biomarkers that can act as tools to classify the tumor status of the patient. Various
biological fluids and tissues have been explored for such studies. Saliva appears to be the most
attractive biological sample with many potential advantages over other matrices such as blood or tissue.
Saliva as a diagnostic fluid has the advantage of ample availability, being non-invasive and being
in the vicinity of the tumor, and having a less complex composition. Our paper provides an updated
review of the state of the art of research in the area of salivary biomarkers for oral squamous cell carcinoma.
The paper gives an account of methods for saliva collection, followed by a brief description of
various protein biomarkers discovered to date, along with their status quo.
Tumor-selective Blockade of CD47 Signaling with CD47 Antibody for
Enhanced Anti-tumor Activity in Malignant Meningioma
Authors: Liu Xiaotong , Zhang Huarong , Wang Chaohu , Li Zhiyong , Zhu Qianchao , Feng Yiwen , Fan Jun , Qi Songtao , Wu Zhiyong , Liu Yi
Published: May 2023

Background:

Patients with WHO grade III meningioma have a poor prognosis with a median
survival of less than two years and a high risk of recurrence. However, traditional treatment options
have failed to improve prognosis. Therefore, development of novel immunotherapy targets is urgently
needed. CD47 acting as a “don't eat me” signal to macrophages can trigger tumor immune escape.
However, the role of CD47 in malignant meningioma is not well understood.

Methods:

We collected 190 clinical meningioma samples and detected the expression of CD47 and
immune infiltration in WHO grade I-III by immunohistochemistry, western blot, qPCR. We also examined
the functional effects of anti-CD47 on cell proliferation, migration and invasion, macrophagemediated
phagocytosis and tumorigenicity both in vitro and in vivo.

Results:

We found that the expression of CD47 was increased in malignant meningioma along with a
decreased number of T cells and an increase in CD68+ macrophages. Blocking CD47 with anti-CD47
antibody (B6H12) suppressed tumor cell growth, motility and promoted macrophage-mediated phagocytosis
in IOMM-Lee cells in vitro. In vivo experiments showed that anti-CD47 antibody (B6H12 or
MIAP301) significantly inhibited the tumor growth and this effect was partly blocked by the depletion
of macrophages. Finally, p-ERK and EGFR showed higher expression in malignant meningioma with
high expression of CD47, which was verified by western blot.

Conclusion:

Our results demonstrated that CD47 maybe involved in the meningioma progression and
prognosis and offered a novel therapeutic option by targeting CD47 in malignant meningioma.
A Decennial Update on the Applications of Trifluroacetic Acid
Authors: Alam Mohammed Mujahid , Varala Ravi , Seema Vittal
Published: May 2023

Since its discovery at the beginning of the 20th century, trifluoroacetic acid, commonly
known as TFA, has seen extensive application in organic synthesis both as a solvent and as a catalyst/
reagent. TFA can be used to facilitate a wide variety of chemical transformations, including rearrangements,
functional group deprotections, condensations, hydroarylations and trifluoroalkylations,
among others. The decennial mini-review examines key TFA synthetic applications from the middle
of 2013 to the present, providing the organic chemistry research community with an opportunity to
delve deeply into the numerous and varied applications of this strong acid, water-miscible, and low
boiling point reagent.
Phytogenic One-pot Synthesis and Spectroscopic Characterization of Novel
Mono Benzylated Resveratrol Hybrid Molecule Using Extracted Resveratrol
from Green Grape Peels: In Silico ADMET Study and In Vitro Antitumor
Activities Against Breast Cancer Cells
Authors: Roy Lairikyengbam Deepti , Kumar Jyotsna , Krishnamurthy Geeta , Gour Pooja , Arland Shivanjali Esther , Rahman Naveed
Published: May 2023

Background:

Despite the development of numerous customized techniques for treating breast cancer, cancer patients' clinical results revealed adverse consequences in addition to chemotherapeutic drug resistance. Hence, finding therapeutic compounds with little or no side effects becomes essential in the fight against cancer. Resveratrol, a naturally occurring non-flavonoid polyphenol present in plants as a phytoalexin, is a promising therapeutic agent that has garnered the interest of several researchers due to its prodigious pharmacological and biological activities, but its unfavourable pharmacokinetic properties complicated its clinical studies. Along with several structural modifications, substitutions, etc., that have already been reported, this is the first time that a novel resveratrol analogue comprising an aromatic hetero moiety (ResD1) was synthesized using resveratrol isolated from grape (Vitis vinifera) peels as a precursor.

Methods:

ResD1 was synthesized by one-pot reaction using extracted and isolated resveratrol from grape peels. Structure confirmation of the isolated resveratrol and synthesized resveratrol derivative was elucidated by 1H-NMR, 13C-NMR, FTIR, and LC-MS. In silico molecular docking and ADMET study of ResD1 were carried out using AutoDock 4.2 and ADMETLab 2.0. ResD1 was evaluated for in vitro antioxidant, antimicrobial, anticancer, and CAXII gene expression as per the standard methods.

Results:

In silico molecular docking results revealed that ResD1 is capable of attaching to the ERα (estrogen receptor alpha) protein via hydrogen and hydrophobic bonds and has -7.12 kcal/mol as docking score. The novel derivative (IC50 = 42.8 µg/ml) exhibited better radical scavenging ability than ascorbic acid (control). The antimicrobial activities exemplify that it can induce microbial cell death for all the strains at higher concentrations. MTT assay results portrayed the potent antiproliferative activity against MCF-7 cell lines (IC50 = 155.2 µg/ml) and non-cytotoxicity for MDA-MB-231 cell lines. Moreover, the synthesized resveratrol derivative induced ROS (reactive oxygen species) levels in MCF-7 cells, indicating cytotoxicity. CAXII gene expression study showed that it downregulated the CAXII genes.

Conclusion:

This study serves as an example of how a newly proposed resveratrol analogue might be utilized as a viable pharmacophore for specifically targeting the ER alpha protein which will be beneficial in investigating a fresh batch of effective resveratrol mimics as prospective anticancer agents.
Calculation of the load-bearing capacity of the bent plates taking into account the diagrams of concrete deformation
Authors: Dzhankulaev A. Y. , Shogenov O. M. , Likhov Z. R. , Kaziyev A. M. , Blyanikhov I. A.
Published: May 2023

Objective. The influence of the nature of the descending branch of concrete compression and stretching diagrams on the ultimate load-bearing capacity of bent cross-section reinforced concrete structures under various loading conditions close to destruction according to the nonlinear finite element model is investigated.

Method. The solution is performed by the finite element method in a physically nonlinear formulation using N.I.Karpenko's deformation theory. Deformation diagrams are used with different steepness of the descending branch. Calculations are performed by a step-by-step iterative method of successive loads on a layered model.

Result. The results of numerical calculation of slab reinforced concrete elements under various conditions of physical nonlinearity of concrete are presented.

Conclusion. The insignificant influence of the steepness of the descending branch on the load-bearing capacity of plate bendable structures has been found and the use of simplified diagram dependencies is fully justified for numerical calculations using a nonlinear model.
Filled bituminous compositions in the construction industry
Authors: Kindeev O. N. , Vysotskaya M. A. , Kurlykina A. V.
Published: May 2023

Objective. The properties of road bitumen, when interacting with the components of building compositions, are always transformed relative to their original properties. Therefore, when working with materials based on filled bitumen compositions, regardless of their field of application, the main task is to monitor the dynamics of changes in characteristics and control in the required direction, as well as maintaining properties such as viscosity, flexibility and fluidity. The purpose of the work is to study the effect of modifying additives of various bases (fillers, plasticizers and waxes) on the properties of a bituminous binder and to evaluate the effectiveness of their contribution to the formation of filled bitumen compositions for the construction industry.

Method. The methodological basis of the work is the principle of bitumen structure formation. Experimental studies were carried out using standard and special methods.

Result. The results obtained showed that fiberglass fiber proved to be the best filler in the bitumen composition. In the study of plasticizers, it was revealed that the most pronounced positive plasticizing effect is observed from the use of an extract of selective oil purification, which allows you to control the flexibility of the system in a wide range. It has been established that the plasticizer polyalkylbenzene effectively regulates the properties of the composition at negative temperatures, slightly affecting the heat resistance. The results of the wax study show that Titan synthetic wax and Viscobit polyethylene wax are evenly distributed in the volume of the bituminous binder and provide stabilization of the system properties.

Conclusion. In the process of performing the study, as well as analyzing the results obtained, 3 groups of bituminous matrix filler additives were studied. It has been established that the directed regulation of the properties of bitumen systems is possible due to the rational choice of the type of additive-filler. Thus, using complex fillings of the bitumen matrix when designing bitumen compositions with the possibility of regulating and normalizing their properties (optimization indicators), it is possible to obtain economic and operational effects.
Modeling of regasification and recirculation processes during the transportation of liquefied natural gas
Authors: Baranov A. Yu. , Seredenko E. S. , Malysheva T. A. , Kravchenko Yu. A.
Published: May 2023

Objective. The purpose of the research is modeling and analysis of technological processes occurring at the transshipment terminal of liquefied natural gas.

Method. The study is based on the methods of thermodynamic analysis, full-scale and computational modeling of processes and objects of refrigeration and cryogenic equipment in order to find optimal solutions in terms of efficiency, reliability and service life of low-temperature installations, machines and apparatus.

Result. The article describes the operation algorithm of an LNG transshipment terminal and proposes a mathematical apparatus for modeling the technological processes occurring in it. Information about the causes of the formation of LNG vapors (Boil-off gas (BOG)) during its transportation and reloading is presented, methods for utilizing excess LNG vapors are considered.

Conclusion. To maintain the cryogenic temperature of the unloading arms, an LNG recirculation line (recirculation pipelines) is provided.
Nonlinear Optimal Control for Six-Phase Induction Generator-Based Renewable Energy Systems
Authors: Rigatos Gerasimos , Abbaszadeh Masoud , Sari Bilal , Siano Pierluigi
Published: May 2023

The article aims at optimizing six-phase induction generator-based renewable energy systems (6-phase IGs or dual star induction generators) through a novel nonlinear optimal control method. Six-phase induction generators appear to be advantageous compared to three-phase synchronous or asynchronous power generators, in terms of fault tolerance and improved power generation rates. The dynamic model of the six-phase induction generator is first written in a nonlinear and multivariable state-space form. It is proven that this model is differentially flat. The 6-phase IG is approximately linearized around a temporary operating point recomputed at each sampling interval to design the optimal controller. The linearization is based on first-order Taylor series expansion and the Jacobian matrices of the state-space model of the 6-phase IG. A stabilizing optimal (H-infinity) feedback controller is designed for the linearized state-space description of the six-phase IG. The feedback gains of the controller are computed by solving an algebraic Riccati equation at each iteration of the control method. Lyapunov analysis is used to demonstrate global stability for the control loop. The H-infinity Kalman Filter is also used as a robust state estimator, which allows for implementing sensorless control for 6-phase IG-based renewable energy systems. The nonlinear optimal control method achieves fast and accurate tracking of setpoints by the state variables of the 6-phase IG, under moderate variations of the control inputs.
Facilitators and Barriers to the Sustainability of eHealth Solutions in Low- and Middle-Income Countries: Descriptive Exploratory Study (Preprint)
Authors: Mamuye Adane , Nigatu Araya Mesfin , Chanyalew Moges Asressie , Amor Lamia Ben , Loukil Sihem , Moyo Chris , Quarshie Samuel , Antypas Konstantinos , Tilahun Binyam
Published: May 2023

BACKGROUND

Despite the widely anticipated benefits of eHealth technologies in enhancing health care service delivery, the sustainable usage of eHealth in transitional countries remains low. There is limited evidence supporting the low sustainable adoption of eHealth in low- and middle-income countries.

OBJECTIVE

The aim of this study was to explore the facilitators and barriers to the sustainable use of eHealth solutions in low- and middle-income nations.

METHODS

A qualitative descriptive exploratory study was conducted in 4 African nations from September to December 2021. A semistructured interview guide was used to collect the data. Data were audio-recorded and transcribed from the local to the English language verbatim, and the audio data were transcribed. On the basis of the information gathered, we assigned codes to the data, searched for conceptual patterns, and created emerging themes. Data were analyzed thematically using OpenCode software.

RESULTS

A total of 49 key informant interviews (10 from Tunisia, 15 from Ethiopia, 13 from Ghana, and 11 from Malawi) were conducted. About 40.8% (20/49) of the study participants were between the ages of 26 and 35 years; 73.5% (36/49) of them were male participants; and 71.4% (35/49) of them had a master’s degree or higher in their educational background. Additionally, the study participants' work experience ranged from 2 to 35 years. Based on the data we gathered, we identified 5 themes: organizational, technology and technological infrastructure, human factors, economy or funding, and policy and regulations.

CONCLUSIONS

This study explores potential facilitators and barriers to long-term eHealth solution implementation. Addressing barriers early in the implementation process can aid in the development of eHealth solutions that will better fulfill the demands of end users. Therefore, focusing on potential challenges would enhance the sustainability of eHealth solutions in low- and middle-income countries.

CLINICALTRIAL
The Effects of Online Health Information–Seeking Behavior on Sexually Transmitted Disease in China: Infodemiology Study of the Internet Search Queries (Preprint)
Authors: Li Xuan , Tang Kun
Published: May 2023

BACKGROUND

Sexually transmitted diseases (STDs) are a serious issue worldwide. With the popularity of the internet, online health information-seeking behavior (OHISB) has been widely adopted to improve health and prevent disease.

OBJECTIVE

This study aimed to investigate the short-term and long-term effects of different types of OHISBs on STDs, including syphilis, gonorrhea, and AIDS due to HIV, based on the Baidu index.

METHODS

Multisource big data were collected, including case numbers of STDs, search queries based on the Baidu index, provincial total population, male-female ratio, the proportion of the population older than 65 years, gross regional domestic product (GRDP), and health institution number data in 2011-2018 in mainland China. We categorized OHISBs into 4 types: concept, symptoms, treatment, and prevention. Before and after controlling for socioeconomic and medical conditions, we applied multiple linear regression to analyze associations between the Baidu search index (BSI) and Baidu search rate (BSR) and STD case numbers. In addition, we compared the effects of 4 types of OHISBs and performed time lag cross-correlation analyses to investigate the long-term effect of OHISB.

RESULTS

The distributions of both STD case numbers and OHISBs presented variability. For case number, syphilis, and gonorrhea, cases were mainly distributed in southeastern and northwestern areas of China, while HIV/AIDS cases were mostly distributed in southwestern areas. For the search query, the eastern region had the highest BSI and BSR, while the western region had the lowest ones. For 4 types of OHISB for 3 diseases, the BSI was positively related to the case number, while the BSR was significantly negatively related to the case number (P<.05). Different categories of OHISB have different effects on STD case numbers. Searches for prevention tended to have a larger impact, while searches for treatment tended to have a smaller impact. Besides, due to the time lag effect, those impacts would increase over time.

CONCLUSIONS

Our study validated the significant associations between 4 types of OHISBs and STD case numbers, and the impact of OHISBs on STDs became stronger over time. It may provide insights into how to use internet big data to better achieve disease surveillance and prevention goals.

CLINICALTRIAL
Effects of SARS-CoV-2 Vaccines on Sperm Quality: Systematic Review (Preprint)
Authors: Li Guanjian , Zhang Rongqiu , Song Bing , Wang Chao , Shen Qunshan , He Xiaojin , Cao Yunxia
Published: May 2023

BACKGROUND

The COVID-19 pandemic, caused by SARS-CoV-2, has triggered a global public health crisis of unprecedented proportions. SARS-CoV-2 vaccination is a highly effective strategy for preventing infections and severe COVID-19 outcomes. Although several studies have concluded that COVID-19 vaccines are unlikely to affect fertility, concerns have arisen regarding adverse events, including the potential impact on fertility; these concerns are plagued by limited and inconsistent evidence.

OBJECTIVE

This review aims to provide a recent assessment of the literature on the impact of COVID-19 vaccines on male sperm quality. The possible impact of COVID-19 vaccines on fertility potential was also examined to draw a clearer picture and to evaluate the effects of COVID-19 on male reproductive health.

METHODS

PubMed, Scopus, Web of Science, Embase, and Cochrane databases were searched from their inception to October 2023. Eligible studies included articles reporting SARS-CoV-2 vaccination and human semen quality and fertility, as well as the impact of vaccination on assisted reproductive technology treatment outcomes. The quality of cohort studies was assessed using the Newcastle-Ottawa Scale, and the quality of cross-sectional studies was assessed using the quality evaluation criteria recommended by the Agency for Healthcare Research and Quality. The systematic review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.

RESULTS

The initial literature search yielded 4691 records by searching 5 peer-reviewed databases (PubMed, Scopus, Web of Science, Embase, and Cochrane). Finally, 24 relevant studies were selected for our study. There were evident research inequalities at the regional level, with the United States and Western European countries contributing 38% (9/24) of the studies, Middle Eastern countries contributing 38% (9/24), China accounting for 21% (5/24), and Africa and South America accounting for none. Nonetheless, the overall quality of the included studies was generally good. Our results demonstrated that serious side effects of the COVID-19 vaccine are extremely rare, and men experience few problems with sperm parameters or reproductive potential after vaccination.

CONCLUSIONS

On the basis of the studies published so far, the COVID-19 vaccine is safe for male reproductive health. Obviously, vaccination is a wise option rather than experience serious adverse symptoms of viral infections. These instances of evidence may help reduce vaccine hesitancy and increase vaccination coverage, particularly among reproductive-age couples. As new controlled trials and prospective cohort studies with larger sample sizes emerge, the possibility of a negative effect of the COVID-19 vaccine on sperm quality must be further clarified.
Gender and Spatial Variations in the Use of Digital Media Related to Adolescents Reproductive Health in Yogyakarta Post-Pandemic Covid-19
Authors: Mulyani Wiwik Puji , Safira Mitha
Published: May 2023

Teenagers have an essential role as part of the development. The proportion of youth ranks highest in the overall population in the world, including Indonesia. The development of the digital world occurs along with the transition of adolescent life which has both good and bad impacts. The impact of the Covid-19 Pandemic became an accelerator for increasing the utility of youth towards digital media. The increase in risky behavior due to technological developments carried out by adolescents raises concerns. On the other hand, technological developments can also positively impact increasing knowledge and attitudes/behaviors, especially regarding health and reproductive issues which are closely related to adolescent development. The purpose of this study was to analyze the knowledge and attitudes/ behaviors of adolescents related to reproductive health, adolescent characteristics and differences in adolescent knowledge according to their demographic characteristics and to analyze the use of digital media for Communication, Information, and Education (IEC) for post-pandemic adolescent reproductive health. This research is quantitative research and the unit of analysis used is the individual level (adolescents). The number of samples was 130 youth and data were analyzed by descriptive quantitative. The results of the study show that adolescents’ knowledge of reproductive health is in a good category, but still needs to be improved. Likewise, regarding attitudes and behavior, there are a few teenagers who have attitudes and behaviors which are vulnerable to problems, such as the consumption of alcohol, cigarettes, drugs, free sexual relations, and others. There are four major digital platforms which are often used and teenagers are comfortable using them to access reproductive health knowledge and information, specifically online mass media, Instagram (IG), Tiktok, and Youtube.
Implementation Analysis of Army Polytechnic Research Management for The Armament Development of The Indonesian Army
Authors: Widodo Arief Cahyo , Hadna Agus Heruanto , Listyaningsih Umi
Published: May 2023

Implementing Vocational Higher Education in The Army Polytechnic (Poltekad) has used the Triple Helix approach: universities, the private sector, and the government. In its development, Poltekad contributes to the direction of the development of the Army’s technological innovation field. Based on observations of the results of Poltekad research, it has yet to be utilized optimally in fulfilling Army equipment and weapons. In the last three years, 2020–2022, 163 final research assignments were recorded by Poltekad students, and 40 research by Poltekad lecturers. However, only eight lecturers’ research has become research models with the potential for defense and development in the Army. This study uses a qualitative research method, specifically a case study. The study results show that Poltekad has not been able to play a role as a research university, but is still limited to its function as a vocational education institution in the technology field. The allocation of research funds for Poltekad is still relatively small compared to the benefits of research to support the development of Army Armaments. The research themes of lecturers and students are not entirely following the needs of the development of Indonesian Army weaponry technology. The absence of a Poltekad external monitoring and evaluation team for research programs, limited educational laboratory facilities, and qualified lecturers as researchers in the Poltekad environment are several reasons for optimizing the utilization of Poltekad research results which cannot be carried out downstream in the implementation of production activities carried out by the Defense Industry in Indonesia as is stated in the Poltekad vision. Poltekad, as a Research University, needs to pay attention to elements, such as 1) budgeting, 2) Research Programs, 3) monitoring, and evaluation, 4) researcher competence, 5) facilitation facilities, 6) information and communication systems, and 7) scientific publications. Downstreaming the themes to utilize research results is carried out according to needs and developments.