bluuebunny/crossref_metadata_2025 huggingface dataset:
Uses of Domestic Water Buffalo Milk in South Sumatra, Indonesia
Authors: Tsuji T , Febriany D S , Widiastuti I , Yazid M
Published: April 2022

This study examines the uses of domestic water buffalo milk in south Sumatra, Indonesia, one of the few areas in not only Indonesia but also the Philippines where the rare practice of milking animals occurs in Southeast Asia. In south Sumatra, both milking domestic water buffalo (Bubalus bubalis) locally known as kerbao pampangan—and making milk products are frequently practiced. The research was thus conducted into the breeding and milking of domestic water buffalo and making of milk products in a Muslim village of the OKI District (Ogan Komering Ilir Regency), south Sumatra, using participant observation, interviews, and questionnaires, to understand the life and culture of the villagers. The findings revealed domestic water buffalo to be the main livestock used for the production and sale of either meat or milk products. Heated milk products, such as candy (gulo puan, sagon puan) and jelly (jerry susu) are produced, probably because fresh milk risks lactose intolerance or milk contaminants, but not yogurt (dadihi), which is produced in north Sumatra. Investigating such unique uses of milk in south Sumatra from an ecological anthropological viewpoint attests to an evident culture of milking domestic water buffalo in south Sumatra, and that arises from the relationship between the people and their livestock. Furthermore, although the murrah (buffalo) is rapidly replacing the domestic water buffalo, due to its higher milk yield, across Southeast Asia, the latter remains predominant in the area.
Ameliorant for Improving the Growth Characters of Garut Indigenous Arabica Coffee
Authors: Supriatna J , Chaidir L , Qodim H , Rismayanti AY
Published: April 2022

One of Garut’s indigenous arabica coffee varieties that have a high and special taste that needs to be developed is known as “Kopi Koneng”. The research was to investigate the ameliorants affected the growth characteristics of two Garut indigenous arabica coffee cutting sections. Research was arranged in Randomized Block Design, consisted of fourteen treatments and three replications. The treatments were mainly several ameliorants compositions were topsoil, chicken manure, and coffee grounds compost. The combination of chicken manure and coffee grounds as a planting media mixture had a substantial effect on plant height and root dry weight, according to the results. Finally, the combination of Yellow Cattura 1 section with a mixture of topsoil media : coffee grounds compost (3:1) provided the best result to increase the growth characters of the arabica coffee seed cuttings.
Host Plant Species Of The New Invasive Pest, Fall Armyworm (Spodoptera Frugiperda) In South Sumatra
Authors: Herlinda S , Simbolon I M P , Hasbi  , Suwandi S , Suparman
Published: April 2022

The new invasive pest, fall armyworm (Spodoptera frugiperda) has been found in West Sumatra since March 2019 and also found in South Sumatera. S. frugiperda has attacked a lot of host plant species. A record of the fall armyworm host plant species is required to comprehend pest’s biology and ecology. The purpose of this study was to identify the host plant species of S. frugiperda. The surveys to collect and to record the host plants have been conducted in South Sumatra consisted of seven districts/cities of Ogan Ilir, Palembang, Lahat, Pagar Alam, Prabumulih, Muara Enim, and Banyuasin. This study has found 28 species of S. frugiperda host plants, such as Zea mays, Elaeis guineensis, Oryza sativa, Lactuca sativa, Brassica oleracea, Amaranthus hybridus, Cucumis sativus, Manihot esculenta, Vigna unguiculata, Arachis hypogaea, Persea americana, Fragaria ananassa, Rosa sp., Ipomoea aquatic, Ipomoea batatas, Solanum melongena. S. frugiperda host plants recorded were 14 plant families, specifically Areceae, Cyperaceae, Poaceae, Musaceae, Asteraceae, Brassicaceae, Amaranthaceae, Cucurbitaceae, Euphorbiaceae, Fabaceae, Lauraceae, Rosaceae, Convolvulaceae, and Solanaceae. There were 13 species of monocot plants and 15 species of dicot plants that can be eaten by S. frugiperda. So, the S. frugiperda has lots of host plant species including monocotyledonous and dicotyledonous plants.
Growth of Sorghum Treated by AMF and OM on Hg Contaminated Soil
Authors: Hidayat C , Rachmawati Y S , Agustina M
Published: April 2022

Gold mining activities leave tailings containing high pollutants including Hg which can inhibit plant growth. To overcome this problem, the application of AMF and organic matter is carried out. The aim of the reserach was to know the effect of Arbuscullar Mycorhizal Fungi and various organic matter on the growth of Sorghum (Sorghum bicolor (L.) A polybag trial at Agrotechnology research station 768 m above sea level had been carried out using randomized block design two factors with factorial pattern and three replications. The first factor was Arbuscullar Mychorhizal Fungi dosage (without AMF inoculum, 5 g polybag−1 AMF inoculum,10 g polybag−1 AMF inoculum,15 g polybag−1 AMF inoculum). The second factor was the type of organic matter (without organic matter, Thitonia diversivolia weed bokhasi 30 t ha−1, humic acid 7.2 ml dissolved in 1.44 L water, Chromolaena odorata weed bokhasi 30 t ha−1). The result showed there was no interaction effect of AMF and various organic matter on root infection degree, plant height, and leaf area. Application of AMF 15 g polybag−1 and C. odorata weed bokhasi 30 t ha−1, respectively, succeeded in increasing the degree of root infection and growth parameters.
Rhizophora Apiculata on Copper and Lead Heavy Metal Substances and Their Effect on Water Quality in Belawan
Authors: Yunasfi  , Leidonald R , Dalimunthe A , Rakesya N
Published: April 2022

The species of mangroves Rhizophora apiculata, R. stylosa, R. mucronata and Bruguiera gymnorhyza, Avicennia marina, Sonneratia caseolaris are among several species of mangroves found in coastal areas. The existence of these mangrove species is a fortress for the coastal environment. Research on the ability of R. apiculata to accumulate heavy metals copper (Cu) and lead (Pb) and their effect on water quality, was carried out from June to September 2021. This research was conducted in Belawan, in Baristan Medan as a place for heavy metal analysis and a laboratory Department of Forest Cultivation, University of North Sumatra. Various types of mangrove plants found in coastal areas have special strategies to deal with pollution conditions from heavy metals. One of several strategies used by mangroves is to accumulate various types of heavy metals in various parts of the tree. R. apiculata is a type of mangrove that can accumulate heavy metals in roots, stems and leaves. The presence of heavy metals will reduce water quality, which in turn will decrease the overall condition of the ecosystem. How big is the ability of mangrove R. apiculata to absorb copper (Cu) and Lead (Pb) and how the environmental conditions of the waters around the mangroves need to be known. Analysis of the heavy metal content of Cu and Pb in the mangrove R. apiculata showed that the heavy metal content of Cu was higher than the metal content of Pb. In the water found in the growing place of R. apiculata, it was found that the Cu content was greater than Pb. Meanwhile, the mud content where the R. apiculata mangrove grows produces heavy metal content of Cu which is smaller than the content of Pb.
Improvement of Thai Sweet Sausage (Goon Chiang) Properties by Oleogel Made of Rice Bran Wax and Rice Bran Oil: A Textural, Sensorial, and Nutritional Aspect
Authors: Issara U
Published: April 2022

Oleogel (OG) has been emphasized as an alternative fat in several food products nowadays. This study aimed to determine the texture profile, fatty acids composition, and sensorial attributes of sweet sausage (Goon Chiang) as well as the fundamental properties of the final product through the supplementation of a mixture of rice bran wax and rice bran oil-oleogel (RBOG). The sausage sample was divided into 4 groups including i) without RBOG added; control, followed by 25%, 50%, and 75% RBOG substitute animal fat, respectively. All samples were measured the texture (hardness, springiness, chewiness, and cohesiveness), total cholesterol together with fatty acids profile as well as sensory properties. The results found out that the highest ratio of animal fat replacement by RBOG in the sweet sausage sample was softer and promoting the lowest cholesterol level when compared with other treatments (p<0.05). Besides, there is no significant difference was observed with total unsaturated fatty acids (USFA) level between 50% and 75% RBOG adding in meat sample. Overall acceptance of the final product was indexed with 50% RBOG (p<0.05). According to the results, it could be used as the fundamental data for developing and improving sweet sausage as a healthy meat product to meet consumer requirements.
Physicochemical Characterization and Shelf-Life Extension of Banana (Musa sp.) via Tapioca starch (Manihot esculenta)/Premna serratifolia Leaves Extract Coating Formulations
Authors: Soleh M S , Mahmood K , Khairuddin N , Saupi N , Kamilah H
Published: April 2022

The aim of this study was to extend the banana (Musa sp.) shelf-life via tapioca (Manihot esculenta) starch (TS) coating formulation. The fruit coating was developed from different concentration of tapioca starch (TS) [2, 4, 6 and 8% w/v], supported for improved hydrophobicity by palm oil (PO) [0.5, 1, 1.5 and 2% v/v] and provided antioxidant properties via Premna serratifolia extract (PE) [1, 2, 3% v/v]. The effect of the fruit coating towards the banana colour, firmness, total soluble solids, and weight loss were evaluated till 8 days at room temperature. The 4% w/v TS showed good control over weight loss and acceptable firmness of banana. Similarly, addition of PO in TS coating significantly improved the barrier properties especially 4% w/v TS + 1% v/v PO indicated lower weight loss and better firmness compared to other treatments. The addition of Premna serratifolia extract (PE) in 4% w/v TS coating improved the colour, lower the weight loss especially 4% w/v TS+ 1% v/v PO + 1% v/v PE. Thus, the addition of PO and PE in the starch coatings could extend the shelf life and quality of fruit at ambient temperature.
Cultivation and Breeding Techniques for Increase Silk Productivity in Indonesia
Authors: Fambayun R A , Agustarini R , Andadari L
Published: April 2022

Silk is one of the textile products derived from plant fibres and is a sericulture product. Sericulture activities have a positive impact on the economy and society, as well as environmental sustainability. The many benefits of sericulture have made the Ministry of Environment and Forestry define silk as one of the potential non-timber forest products to be developed. However, there are many obstacles in developing sericulture, especially upstream (moriculture and silkworm rearing), namely low productivity. Forestry Research and Development Center is one of the stakeholders in silk development. This paper reviews the activities carried out by FRDC related to natural silk, both the development of mulberry and silkworms. The three activities carried out include research on cultivation techniques, conservation and breeding of mulberry plants and silkworms. Increased productivity is obtained by crossing or hybridization to get superior seeds. The superior products produced are Suli 01 mulberry seeds, PS 01 silkworm hybrids, and sericulture development techniques with high productivity. The Suli 01 mulberry hybrid had 30% more leaf production than conventional mulberry (M. cathayana), and the PS 01 silkworm hybrid increased cocoon production per box by 40% compared to the commonly used C301 silkworm.
Impact of Palm Oil By-Products Application to Earthworm Populations and Soil Chemical In Oil Palm Plantation
Authors: Edyson  , Murgianto F , Ardiyanto A
Published: April 2022

Palm oil mill has by-products from processing fresh fruit bunch such as empty fruit bunch and fruit fiber that benefits oil palm plantation. The aim of this research was to observe earthworms population and soil chemical properties after the application of palm oil by-products. This research was conducted in Pantai Harapan Estate PT Bumitama Gunajaya Agro, Central Kalimantan from July 2020 - May 2021. The organic matter was used in this study were empty bunch, empty bunch compost, and pressed fruit fiber, applied in an oil palm circle in two different soil types. The earthworms population was observed before and six months using a square sampling size 1 m x 1 m at a depth of 0,15 m. The earthworms population after six months with organic application both in dystrudepts and haplohumods range from 46 to 119 individuals/m2. Earthworms population increased 22,17% and 71,33% after six month, compared to control decrease 48,21% and 68,51% in haplohumods and dystrudepts respectively. Soil chemical properties such as C-organic, total P, and K are significantly different after organic application compared to control both in haplohumods and dystrudepts. Thus, the application of organic matter is able to increase the earthworms population and improve soil chemical properties in oil palm plantations.
Microchannel cooling technique for dissipating high heat flux on W/Cu flat-type mock-up for EAST divertor
Authors: LU Mingxiang , HAN Le , ZHAO Qi , QIU Juncheng , ZHOU Jianhong , HU Dinghua , MOU Nanyu , CHEN Xuemei
Published: April 2022

As an important component of tokamaks, the divertor is mainly responsible for extracting heat and helium ash, and the targets of the divertor need to withstand high heat flux of 10 MW m−2 for steady-state operation. In this study, we proposed a new strategy, using microchannel cooling technology to remove high heat load on the targets of the divertor. The results demonstrated that the microchannel-based W/Cu flat-type mock-up successfully withstood the thermal fatigue test of 1000 cycles at 10 MW m−2 with cooling water of 26 l min−1, 30 °C (inlet), 0.8 MPa (inlet), 15 s power on and 15 s dwell time; the maximum temperature on the heat-loaded surface (W surface) of the mock-up was 493 °C, which is much lower than the recrystallization temperature of W (1200 °C). Moreover, no occurrence of macrocrack and ‘hot spot’ at the W surface, as well as no detachment of W/Cu tiles were observed during the thermal fatigue testing. These results indicate that microchannel cooling technology is an efficient method for removing the heat load of the divertor at a low flow rate. The present study offers a promising solution to replace the monoblock design for the EAST divertor.
Racial Disparities in the Child Welfare System
Authors: Dettlaff Alan J.
Published: April 2022

Racial disproportionality and disparities have been documented in the child welfare system in the United States since at least the 1960s, yet they persist as a national problem. This article provides an overview of the history of racial disproportionality and disparities in child welfare systems, the continuing presence of racial disproportionality and disparities, and the factors that contribute to racial disproportionality and disparities. The article concludes with strategies that have been developed over the years to address racial disproportionality and disparities, including calls for abolition of the child welfare system as a means of addressing these persistent problems.
Black Lives Matter
Authors: Delozia Mildred , Birore Charles M. S.
Published: April 2022

Black Lives Matter (BLM), which led to the Black Lives Matter movement (BLMM), has been described as a movement with a global following. The movement is aligned with the social work profession’s purpose and values. The social work profession is a human rights profession and has a history of involvement with movements, beginning with the settlement house movement in the late 19th century. The BLMM frames its narrative based on human rights and espouses an agenda that calls out injustice in all facets of social justice. Therefore, a central aim is to understand the BLMM from multiple perspectives. Definitions, theoretical perspectives, and types of social movements are presented, and then the framework of social movements is used to understand the BLMM. Finally, the BLMM is examined in relation to historical social movements, advocacy organizations, and criminal justice reform.
HDIContact: a novel predictor of residue–residue contacts on hetero-dimer interfaces via sequential information and transfer learning strategy
Authors: Zhang Wei , Meng Qiaozhen , Wang Jianxin , Guo Fei
Published: April 2022

Proteins maintain the functional order of cell in life by interacting with other proteins. Determination of protein complex structural information gives biological insights for the research of diseases and drugs. Recently, a breakthrough has been made in protein monomer structure prediction. However, due to the limited number of the known protein structure and homologous sequences of complexes, the prediction of residue–residue contacts on hetero-dimer interfaces is still a challenge. In this study, we have developed a deep learning framework for inferring inter-protein residue contacts from sequential information, called HDIContact. We utilized transfer learning strategy to produce Multiple Sequence Alignment (MSA) two-dimensional (2D) embedding based on patterns of concatenated MSA, which could reduce the influence of noise on MSA caused by mismatched sequences or less homology. For MSA 2D embedding, HDIContact took advantage of Bi-directional Long Short-Term Memory (BiLSTM) with two-channel to capture 2D context of residue pairs. Our comprehensive assessment on the Escherichia coli (E. coli) test dataset showed that HDIContact outperformed other state-of-the-art methods, with top precision of 65.96%, the Area Under the Receiver Operating Characteristic curve (AUROC) of 83.08% and the Area Under the Precision Recall curve (AUPR) of 25.02%. In addition, we analyzed the potential of HDIContact for human–virus protein–protein complexes, by achieving top five precision of 80% on O75475-P04584 related to Human Immunodeficiency Virus. All experiments indicated that our method was a valuable technical tool for predicting inter-protein residue contacts, which would be helpful for understanding protein–protein interaction mechanisms.
scSGL: kernelized signed graph learning for single-cell gene regulatory network inference
Authors: Karaaslanli Abdullah , Saha Satabdi , Aviyente Selin , Maiti Tapabrata
Published: April 2022

Motivation

Elucidating the topology of gene regulatory networks (GRNs) from large single-cell RNA sequencing datasets, while effectively capturing its inherent cell-cycle heterogeneity and dropouts, is currently one of the most pressing problems in computational systems biology. Recently, graph learning (GL) approaches based on graph signal processing have been developed to infer graph topology from signals defined on graphs. However, existing GL methods are not suitable for learning signed graphs, a characteristic feature of GRNs, which are capable of accounting for both activating and inhibitory relationships in the gene network. They are also incapable of handling high proportion of zero values present in the single cell datasets.

Results

To this end, we propose a novel signed GL approach, scSGL, that learns GRNs based on the assumption of smoothness and non-smoothness of gene expressions over activating and inhibitory edges, respectively. scSGL is then extended with kernels to account for non-linearity of co-expression and for effective handling of highly occurring zero values. The proposed approach is formulated as a non-convex optimization problem and solved using an efficient ADMM framework. Performance assessment using simulated datasets demonstrates the superior performance of kernelized scSGL over existing state of the art methods in GRN recovery. The performance of scSGL is further investigated using human and mouse embryonic datasets.

Availability and implementation

The scSGL code and analysis scripts are available on https://github.com/Single-Cell-Graph-Learning/scSGL.

Supplementary information

Supplementary data are available at Bioinformatics online.
XePhIR: the zebrafish xenograft phenotype interactive repository
Authors: Groenewoud A , Forn-Cuní G , Engel F B , Snaar-Jagalska B E
Published: April 2022

Zebrafish xenografts are an established model in cancer biology, with a steadily rising number of models and users. However, as of yet, there is no platform dedicated to standardizing protocols and sharing data regarding zebrafish xenograft phenotypes. Here, we present the Xenograft Phenotype Interactive Repository (XePhIR, https://www.xephir.org) as an independent data-sharing platform to deposit, share and repurpose zebrafish xenograft data. Deposition of data and publication with XePhIR will be done after the acceptation of the original publication. This will enhance the reach of the original research article, enhance visibility and do not interfere with the publication or copyrights of the original article. With XePhIR, we strive to fulfill these objectives and reason that this resource will enhance reproducibility and showcase the appeal and applicability of the zebrafish xenograft model.

Database URL: https://www.xephir.org
Association between β-blocker dose and quality of life after myocardial infarction: a real-world Swedish register-linked study
Authors: Humphries Sophia , Wallert John , Mars Katarina , Held Claes , Hofmann Robin , Olsson Erik M G
Published: April 2022

Background

β-blockers are routinely administered to patients following myocardial infarction (MI), yet their potential effect on health-related quality of life (HRQoL) is not entirely understood. We investigated the relationship between two different doses of β-blockers with HRQoL following MI.

Methods and results

This nationwide observational study used Swedish national registries to collate sociodemographic, clinical, medication, and HRQoL {the latter operationalized using EuroQol [European Quality of Life Five Dimensions Questionnaire (EQ-5D)]}. Estimates at 6–10 weeks and 12–14 months post-MI follow-up from pooled linear and logistic models were calculated after multiple imputation. We identified 35 612 patients with first-time MI, discharged with β-blockers, and enrolled in cardiac rehabilitation between 2006 and 2015. Upon discharge, patients were either dispensed <50% [24 082 (67.6%)] or ≥50% [11 530 (32.4%)] of the target dosage, as defined in previous trials. After adjusting for pre-defined covariates, neither the EQ-5D Index nor the Emotional Distress items were statistically different between groups. The EQ-VAS score was significantly lower in patients treated with ≥50% target β-blocker dose than those treated with <50% of the target dose [−0.87 [−1.23, −0.46], P < .001]. Results were similar at the 12-month follow-up and across sub-groups separated by sex and age.

Conclusion

No difference in HRQoL was found among patients taking <50% vs. ≥50% of the target β-blocker dose, except for the EQ-VAS in which higher scores were reported in those taking a lower dose. The clinical meaningfulness of this statistical significance is likely low.
Mechanical versus bioprosthetic valve for aortic valve replacement: systematic review and meta-analysis of reconstructed individual participant data
Authors: Tasoudis Panagiotis T , Varvoglis Dimitrios N , Vitkos Evangelos , Mylonas Konstantinos S , Sá Michel Pompeu , Ikonomidis John S , Caranasos Thomas G , Athanasiou Thanos
Published: April 2022

OBJECTIVES

The aim of this study was to compare biological versus mechanical aortic valve replacement.

METHODS

We searched MEDLINE, Scopus and Cochrane Library databases for randomized clinical trials and propensity score-matched studies published by 14 October 2021 according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. Individual patient data on overall survival were extracted. One- and two-stage survival analyses and random-effects meta-analyses were conducted.

RESULTS

A total of 25 studies were identified, incorporating 8721 bioprosthetic and 8962 mechanical valves. In the one-stage meta-analysis, mechanical valves cumulatively demonstrated decreased hazard for mortality [hazard ratio (HR): 0.79, 95% confidence interval (CI): 0.74–0.84, P < 0.0001]. Overall survival was similar between the compared arms for patients <50 years old (HR: 0.88, 95% CI: 0.71–1.1, P = 0.216), increased in the mechanical valve arm for patients 50–70 years old (HR: 0.76, 95% CI: 0.70–0.83, P < 0.0001) and increased in the bioprosthetic arm for patients >70 years old (HR: 1.35, 95% CI: 1.17–1.57, P < 0.0001). Meta-regression analysis revealed that the survival in the 50–70 year-old group was not influenced by the publication year of the individual studies. No statistically significant difference was observed regarding in-hospital mortality, postoperative strokes and postoperative reoperation. All-cause mortality was found decreased in the mechanical group, cardiac mortality was comparable between the 2 groups, major bleeding rates were increased in the mechanical valve group and reoperation rates were increased in the bioprosthetic valve group.

CONCLUSIONS

Survival rates seem to not be influenced by the type of prosthesis in patients <50 years old. The survival advantage in favour of mechanical valves is observed in patients 50–70 years old, while in patients >70 years old bioprosthetic valves offer better survival outcomes.
OR2. A significant ten-year risk of fatal cardiovascular disease estimation to predict D-Dimer level in hospitalised COVID-19 patients
Authors: Cristo Yosua , Napitupulu Bertha G , Simanjuntak Mutiara
Published: April 2022

Aims

After the COVID-19 pandemic, the risk of thrombosis and bleeding has been an important issue. It is reported that higher D-dimer levels are associated with poor prognosis. Cardiovascular disease risk has also been reported to poor prognosis of COVID-19. Both cardiovascular disease risk and high D-dimer level can be a lethal combination leading to death in COVID-19 patients. We are aiming this research to analyse the capability ten-year risk of fatal cardiovascular disease obtained from SCORE-Risk chart to predict the D-dimer level in hospitalised COVID-19 patients.

Methods and Results

This is a cross-sectional study including 85 moderate-severe hospitalised COVID-19 patients without previous cardiovascular disease. We assessed the patient’s cardiovascular risk by using SCORE-Risk chart and separate samples into two D-dimer groups. Comparison between patient’s clinical variables and D-Dimer level is done by using Mann-Whitney analysis. Variables which show p value <0.2 will then be analysed by Logistic Regression.

There are 27 patients (31.8%) with a high cardiovascular risk. Median D-dimer is 560 ng/mL. Mann-Whitney analysis comparing patient’s clinical variables with D-dimer shows CRP, blood glucose, lactic acid and SCORE-Risk chart give p-value with value < 0.2. The logistic regression analysis shows that SCORE-Risk chart is the strongest predictor of higher D-dimer level with OR 5.647 (1.670-19.092; p value 0.005) with 88.2% specificity and 45.1% sensitivity.

Conclusions

Ten-year risk of fatal cardiovascular disease measured by SCORE-risk chart can be used as accurate predictor of higher D-dimer level on moderate-severe COVID-19 patients.
OR10. Association between heart functional capacity with depression severity on patient with coronary artery disease
Authors: Pintaningrum Y , Humaera N N , Rafiq A , Tanti A
Published: April 2022

Aims

Coronary artery disease has become the main factor of heart failure. Current research has shown association between heart failure with depression. However even before the heart failure, patient with coronary artery diseases may have depression. This study aims to investigate the correlation between heart functional capacity based on new york heart association scale with presence and severity of depression in patient with coronary artery disease.

Methods and Results

50 Patients diagnosed with coronary artery diseases who agree to participate completes patient health questionnaire-9. Patient’s coronary artery disease severity determined by patient functional heart based on capacity new york heart association. Chi square test used to find correlation.

Discussion

Based on chi-square methods (sig new york heart association: 0.014, patient health questionnaire: 0.021) p < 0.05, there is a strong correlation between functional heart capacity based on new york heart association assessment with presence and severity of depression in patient with coronary artery diseases. It shows the correlation not only found in heart failure patient and the depression confirmed in coronary artery disease patients at Nusa Tenggara Province Hospital using patient health questionnaire-9.
OR13. Cardiac Arrythmias on COVID19 Patients: Characteristics, Correlated Risk Factors and Associated Outcomes
Authors: Najiyah H H , Prakoso P P , Wardhani D , Rahmawati M , Wibowo R H , Tiksnadi B B
Published: April 2022

Background

Arrythmias in COVID19 patients were often found. This study was aimed to investigate characteristic, risk factors, and outcome of arrhythmic COVID19 patients.

Methods

This was a single-centered study. All confirmed COVID19 patients admitted from May 2020 until March 2021 were included. Data were obtained from medical records. Patients with no ECG or incomplete medical record were excluded. Bivariate analysis through Chi Square was used to define association between arrhythmia risk factors, and outcomes.

Results

374 patients were included, ranged from 2 until 85 years old (mean 52.5 ± 15, median 54). Mostly were males (53.7%) with 10 days median hospice care. Fifty eight patients (15.50%) had arrhythmia, which were mainly sinus tachycardia, supraventricular tachycardia, ventricular extra systole (3.7% each) and atrial fibrillation (3.5%). Congestive heart failure (CHF) (31.9%) and hypertension (28.7%) were the main comorbid. Bivariate analysis was conducted. CHF increased risk of arrhythmia by two times (RR: 2.15, CI 95%: 1.21 – 3.83, p < 0.008) and chloroquine use by 1.17 times (RR: 1.17, CI 95%: 1.05 – 1.11, p < 0.04). Arrhythmia events increased mortality risk by 2.5 times (RR: 2.52, CI 95%: 1.41–4.48, p < 0.001). Eighteen patients (31.03%) with arrhythmia died, especially those with atrial fibrillation (7 patients).

Conclusion

Sinus tachycardia, supraventricular tachycardia, ventricular extra systole, and atrial fibrillation were the most arrhythmia found. CHF and the use of chloroquine increased risk of arrhythmia. Arrythmia itself, especially atrial fibrillation, should be monitored as it increased mortality.
OR14. Cardiac Index by Right Heart Catheterization was an Independent Predictor of Mortality in Adult Pulmonary Arterial Hypertension-associated with Congenital Heart Disease with Shunt
Authors: Rochmat M B , Dinarti L K , Setianto B Y , Hartopo A B , Anggrahini D W , Satwiko M G
Published: April 2022

Background and Aims

Pulmonary arterial hypertension (PAH) is a common complication of congenital heart disease (CHD). There were several variables predictor of mortality in PAH-CHD from previous studies, but study predictor of mortality in PAH-CHD with shunts has never been done, especially in Indonesia. This study aims to identify independent predictors of mortality among adult PAH-CHD with shunt in Dr. Sardjito Hospital, Yogyakarta, Indonesia.

Method and Results

We conducted a retrospective cohort study that included adult PAH-CHD patients with shunts from COHARD-PH (The Congenital HeARt Disease in adult and Pulmonary Hypertension) registry who were recruited from July 2012 - October 2020. Twelve variables were selected as potential predictors of mortality. Predictor variables were obtained from clinical (WHO-functional class, SaO2, 6-min walking distance), laboratory (haemoglobin, NT-pro BNP), echocardiographic (pericardial effusion, defect size, TAPSE), and hemodynamic (RA pressure, cardiac index, SvO2, flow ratio) data at the time of diagnosis of PAH. Baseline characteristics showed significantly lower systolic blood pressure, higher incidence of Eisenmenger syndrome, higher NT-pro BNP, and lower cardiac output in subjects who died as compared to those survived. Multivariate analysis showed cardiac index as an independent predictor of mortality (OR 7.69; p = 0.011). Systolic blood pressure was a significant confounder of cardiac index in affecting mortality (OR 10.56; p = 0.001).

Conclusion

Cardiac index was an independent predictor of mortality of PAH-CHD with shunts. Systolic blood pressure was a significant confounder of cardiac index on mortality.
OR28. Diagnostic delay in Congenital Heart Disease Related Pulmonary Arterial Hypertension: Insights from the Single Tertiary Hospital Center of Patients With Pulmonary Hypertension Registry In East Java Indonesia
Authors: Fadlan Muhamad Rizki , Aziz Indra Jabar , Martini Heny
Published: April 2022

Aims

The aim of this study was to determine the time from the onset of symptoms to the diagnosis of PAH associated with CHD in Saiful Anwar general Hospital,Malang and to determine the factors with delayed definitive diagnosis.

Methods

The Registry enrolled 128 adult patients with CHD-PAH from January 2019 to December 2020. Patients were considered to have delayed disease recognition if . 2 years elapsed between symptom onset and the patient receiving a CHD-PAH diagnosis, starting on PAH-specific therapy, or receiving a diagnosis by right-sided heart catheterization.

Results

In 54.6% of patients, symptoms were experienced > 2 years before CHD-PAH was recognized. The mean diagnostic interval from symptom onset to diagnostic RHC was 3.18 ± 1.75 years, while Overall, 9.3%, 25% and 65.7% of patients were diagnosed after <1, 1–2 and > 2 years, respectively). There was significant proportion of delayed diagnosed > 2 years in Secundum ASD compare than ≤ 2 years (74.3% vs 51.7%. Respectively, ,p=0.014, OR 2.6 95%CI : 1.2-5.6). Patients who life in remote area (OR 1.82; 95%CI 1.48-2.26), and General practitioner as Physician consulted at symptom onset (OR 1.72;95%CI 1.64-2.46) were independent predictors of longer diagnostic interval. We found significant different level of MPAP and PVR in patients who was delayed time to diagnosed CHD related to PAH > 2 years compare than ≤ 2 years (55.32±8.8 vs 42.4±10.2, 10.6±1.28 vs 4.2±1.42 respectively ,P=0.014, P = 0.012).

Conclusions

We show’s that ASD secundum as subtype of CHD, Patients who life in remote area, and General practitioner as Physician consulted at symptom onset were independent predictors of longer diagnostic interval.
OR37. Factors associated with in-hospital mortality in patients hospitalized with acute coronary syndrome
Authors: Ardining H , Niazta N A , Karimullah D H
Published: April 2022

Background and Aims

Acute coronary syndrome (ACS) remains a source of high mortality worldwide, therefore it is important to determine factors associated with worse outcomes to better develop strategies to reduce the burden of disease. This paper aims to describe the characteristics of patients admitted with ACS to Kediri General Hospital and factors associated with in-hospital mortality.

Methods and Result

In this study, 117 patients admitted with ACS to Kediri General Hospital between January and June 2020 were included. Data were collected retrospectively from medical records and analysed using SPSS software v25. The median age was 60 (36-93) years old, 64 (54,7%) were male. They were presented either with STE-ACS (41%) or NSTE-ACS (59%). During hospitalization, 18 (15,4%) died. The bivariate analysis showed the patients who died were predominantly female (22,6% vs 9,4%, p = 0.048); had higher prevalence of Killip IV (38,9%, p = 0,003); higher prevalence of clinical signs of heart failure (23,7% vs 6,9%, p = 0,012); lower admission systolic blood pressure (117 ± 26,0 vs 137 ± 37,0, p = 0,036); lower admission diastolic blood pressure (70,6 ± 20,6 vs 81,5 ± 20,5, p = 0,04); and higher heart rate (104 ± 24 vs 91 ± 22, p = 0,026). From multivariable analysis, variables significantly associated with in-hospital mortality were decreased consciousness (OR 11, 95% CI 1.327-92.4, p = 0.026) and Killip class IV (OR 9.558, 95% CI 2.016-45.317).

Conclusion

Decreased consciousness and Killip class IV were significant independent predictors of in-hospital mortality in ACS.
OR45. Improving the migratory function of endothelial progenitor cells under high glucose conditions via engineering with human umbilical cord blood mesenchymal stem cell-derived secretome
Authors: Susanti M , Oktaviono Y H , Lefi A
Published: April 2022

Aims

Human umbilical cord blood mesenchymal stem cells (hUCB-MSC) secreted a group of paracrine factors known as secretome. It has the ability to promote neovascularization and angiogenesis, and it is thought to be capable of modulating EPC function. The capability of hUCB-MSCs-derived secretome in enhancing EPC migration under high glucose condition, which is expected to mimic the metabolic disturbance that occurs in patients with type 2 diabetes mellitus, has been not yet established. This study aims to elucidate the effect of Human Umbilical Cord Blood Mesenchymal Stem Cell (hUCB-MSCs)-derived secretome on the EPCs migration under high glucose conditions.

Method and Results

EPCs were isolated from peripheral blood samples of chronic coronary syndrome patient and cultured for three days. Cultured EPCs were incubated with high glucose for five days and were treated with secretome at various concentration. The migration of EPCs was assessed using the Transwell migration assay. hUCB-MSC-derived secretome induced the migration capability of EPC with at least 20% concentration of secretome, this effect was more potent under high glucose conditions with the least concentration of secretome was 10% (p < 0.001). The migratory function of EPCs was intact on short term exposure of high glucose.

Conclusion

Our finding suggest that hUCB-MSCs-derived secretome may enhance migratory function of EPCs under high glucose conditions. hUCB-MSCs-derived secretome may serve as a promising cell-free regenerative therapy.
OR50. The Prevalence of Cardiovascular Comorbidity in the Severe COVID-19 Patients and Its Correlation to Malignant Ventricular Arrhythmia, Neutrophile-Lymphocyte Ratio (NLR) and D-Dimer
Authors: Siagian A P B , Napitupulu B G
Published: April 2022

Aims

This study aims to describe the prevalence of cardiovascular comorbidities and its correlation to ventricular arrhythmia, NLR and D-Dimer levels in the severe COVID-19 patients.

Methods

This study was a retrospective analytical study. The data of severe COVID-19 patients from Murni Teguh and Susanna Wesley Hospital Medan from January to May 2021 were collected. Data of cardiovascular comorbidities, cause of death, NLR, and D-dimer levels were collected. The categorical data were analysed using Chi-Square, while the numerical data were analysed using an independent T-test or Mann-Whitney test.

Results

Ninety samples were collected. The causes of death were unshockable cardiac arrest (64.8%), ventricular arrythmia (12.2%), and septic shock (22.2%). There were 43 (47.3%) patients with cardiovascular comorbidites. Coronary arterial disease (27.5%) was the most prevalent. Any cardiovascular comorbidites (P = 0.016, OR = 5.956, CI = 1.208 – 29.370) and CAD (P = 0.044, OR = 3.789, CI = 1.309 – 13.823) were significantly related to ventricular arrythmia. The NLR-Ratio was higher in atrial fibrillation patients (42.21 ± 45.84, P = 0.031). The D-dimer level was higher in patients with any CV comorbidities (5488.47 ± 6252.22 ng/mL, P = 0.021), heart failure (5564.70 ± 9495.52 ng/mL, P = 0.033) and in hypertensive heart disease (5873.63 ± 8495.84 ng/mL, P = 0.01).

Conclusion

Cardiovascular comorbidities are common among severe COVID-19 patients and increase the risk of ventricular arrhythmia, NLR value in AF and D-dimer level in any CV comorbidities, HF, and HHD patients.
OR53. Relation between platelet distribution width level with left ventricle global longitudinal strain on acute myocard infarct patient
Authors: Mahmud S , Wasyanto T
Published: April 2022

Background and aims

In patients with acute myocardial infarction (AMI), global longitudinal strain (GLS) is a more sensitive marker than left ventricular ejection fraction (LVEF) in assessing left ventricular function, and the prognostic impact of marker of platelet distribution width (PDW) has also been reported in this setting. The aim of this study was to investigate the relationship between PDW and GLS in patients with AMI.

Methods and results

A total of 38 patients with AMI (31 males and 7 females), both with ST segment elevation (STEMI) and non ST segment elevation (NSTEMI) were included. Blood samples were drawn at presentation and echocardiography was performed within 24 hours of presentation. Median PDW levels was 16.0%, and median GLS was -9.9%. A positive correlation was found between PDW levels and GLS (r = 0.339, p = 0.037).

Conclusion

Among patients with AMI, elevated PDW levels were associated with poor left ventricular function. This finding suggests that determining PDW levels within 24 hours following AMI may have beneficial prognostic value in predicting left ventricular function.
OR58. Six-minute walk test as a predictor of 1 year clinical outcome in patient presenting with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
Authors: Khairat M , Vallerian W , Hanika R , Hamdani R , Krevani K C
Published: April 2022

Aim

Impairment of exercise capacity has a poor prognostic impact in post-myocardial infarct patient. The 6-minute walk test (6MWT) is a safe and simple methode that is used in assessing exercise capacity. However, there is limited data on the impact of 6MWT result as a prognosis in clinical outcome patient with ST-elevation myocardial infarct (STEMI). The aim of this study is to determine correlation between 6MWT result with 1 year clinical outcome (hospital readmission and death) of STEMI patients underwent PPCI

Methods

We obtained relevant and clinical data from our hospital database of 169 patients diagnosed with STEMI underwent PPCI procedure and performed 6MWT before hospital discharged during 2019. Patients were divided into 3 groups according to the level of 6MWT result (Level I: <300m; Level II: 300-450m; Level III: >450m). 1 year clinical outcome was obtained from medical record and direct contact to the patients. Statistical analysis was performed using SPSS

Result

Of the 169 patients included in the study population, the mean age was 58.73±9.88 year old, 122 males. Majority of patients was in level II (n = 50.3%) followed by level I (n = 32.0%) and level III (n = 17.8%). The highest readmission was in level I (n = 16.0%, p = 0,000). The highest mortality rate occurred in group II (n = 1.8%, p = 0,572)

Conclusion

6MWT that is performed before hospital discharged in STEMI patient undergoing PPCI have a correlation with 1 year clinical outcome, and appears to be a predictor of hospital readmission within 1 year
OR71. The relationship between daily intake of folic acid, vitamin B6, and vitamin B12 and ankle brachial index peripheral artery disease patients in Mataram
Authors: Qurniadi M T , Indrayana Y , Irawati D
Published: April 2022

Aims

The aim of this study was to determine the relationship between intake levels of folic acid, vitamin B6, and vitamin B12 with the value of the Ankle Brachial Index (ABI) in patients with peripheral artery disease in Mataram City.

Methods and Results

This study is a cross sectional study conducted at Siti Hajar Islamic Hospital in Mataram. The sample was patients with peripheral artery disease with an ABI value less than 0.90. The number of research samples was 52 subjects. Data Folic acid, vitamin B6, and vitamin B12 daily intake were collected using the 24-hours food recall method. The sampling technique used consecutive sampling method. Data analysis used the Spearman correlation test. The average daily intake of folic acid, vitamin B6, and vitamin B12 in the study sample wass less than 50% of the recommended daily nutritional adequacy rate for Indonesians. The average ABI in the sample was 0.79. The results of the Spearman correlation test between ABI and folic acid intake showed p value = 0.020 and r = 0.322. The results of the Spearman correlation test between the ABI and vitamin B6 intake showed p value = 0.167. The results of the Spearman correlation test between ABI and vitamin B12 intake showed p value = 0.800.

Conclusion

There is a significant relationship between ABI and folic acid intake. There is an insignificant relationship between ABI and vitamin B6 and vitamin B12.
OR78. The utility of shock index, modified shock index and age shock index to predict in-hospital mortality and icu admission in patients hospitalized with acute coronary syndrome
Authors: Niazta N A , Ardining H , Karimullah D H
Published: April 2022

Aims

The shock index (SI), the modified shock index (MSI), and the age shock index (ASI) are simple scales which can be obtained bedside. These scales have been studied to predict outcomes in various diseases. We aimed to evaluate the use of SI, MSI and ASI in patients hospitalized with acute coronary syndrome (ACS).

Method and Result

In this cross-sectional study, 102 patients who were admitted with ACS to Kediri General Hospital between January and June 2020 were included. Patients who presented with shock were excluded. We calculated for each patient the admission SI (defined as heart rate/systolic blood pressure), MSI (heart rate/mean arterial pressure), and ASI (age × SI). The mean SI was 0.70 ± 0.20, MSI was 0.95 ± 0.23 and ASI was 42.33 ± 14.17. Receiver-operating characteristic (ROC) curve analysis was used to assess the ability of SI, MSI and ASI to predict in-hospital mortality and ICU admission. The observed AUC of SI was 0.706 (95% CI 0.572-0.840), MSI was 0.705 (95% CI 0.58-0.83), and ASI was 0.687 (95% CI 0.540-0.834) in predicting in-hospital mortality. The cut-off point for SI was 0.75 with sensitivity of 69.2% and specificity of 67.4% in predicting in-hospital mortality. MSI demonstrated better C-statistics (0.665, 95% CI = 0.565 - 0.765) in predicting ICU admission.

Conclusion

SI had the best predictive value for in-hospital mortality compared with MSI and ASI, while MSI could predict ICU admission in patients with ACS.
M6. Effectiveness of Telemedicine Interventional Management in Adult With Heart Failure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Widhiarta P R , Sanjiwani N P G R
Published: April 2022

Aims

There is growing evidence that Telemedicine Interventional Management (TIM) can be advantageous in societies with an increasing prevalence of Heart Failure (HF). The objective of this meta-analysis was to assess the effectiveness of telemedicine intervention for patients with HF compared with conventional healthcare.

Method and Result

We systematically searched PubMed, MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials for randomized controlled trials (RCT) from January 2010 to December 2020. The primary effectiveness outcome was all-cause mortality. Secondary outcomes were all-cause hospitalization, cardiovascular mortality, and heart failure hospitalization. We include data from 15 RCTs comprising data for 11,262 patients. Telemedicine resulted in statistically significant risk reduction of all-cause mortality (OR 0.81, 95% CI 0.72–0.91, p = 0.0004). Receiving Telemedicine interventions is likely to reduce the hospitalization for all causes (OR 0.90, 95% CI 0.83-0.98, p = 0.02, I2 = 84%) and the hospitalization due to HF (OR 0.88, 95% CI 0.72-0.99, p = 0.04, I2 = 61%), compared with interventions from conventional healthcare. OR of telemedicine cardiac mortality (OR 0.82, 95% CI 0.70-0.97, p = 0.02, I2 = 0%).

Conclusion

Compare with conventional healthcare, telemedicine intervention combines with medical support prove to be more effective for HF adult, particularly in reducing all-cause mortality, all-cause hospitalization, cardiovascular mortality, and heart failure hospitalization. While further research is required to confirm these findings and identify optimal telemedicine strategies and the duration of follow-up for which it confers benefits.