bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of transferring a poor-quality embryo together with a good-quality embryo on the singleton birth weight: A retrospective cohort study
Authors: Dashti Saeideh , Pejman Atefeh , Tabibnejad Nasim , Mortezanasab Maedeh
Published: March 2022

Background: Embryo quality may affect birth weight among neonates born through assisted reproductive technology. There are very limited studies assessing the adverse effect of transferring a poor-quality embryo with a good-quality one on neonatal outcomes.
Objective: The aim of this study was to evaluate the effect of double embryo transfer (DET) with one good-quality embryo (GQE) plus a poor-quality one on the birth weight of newborns conceived by in vitro fertilization in both fresh and frozen-thawed embryo transfer cycles.
Materials and Methods: This study was conducted at Yazd Reproductive Sciences Institute, Yazd, Iran. A total of 626 women were classified into three groups according to the embryo quality: single embryo transfer with a GQE (group A); DET using two GQEs (group B); and DET using one good-quality and one poor-quality embryo (group C). The primary outcome was singleton birth weight which was compared between the three groups among fresh and frozen-embryo transfer cycles. A comparative analysis was also performed regarding the effect of vitrification procedures on neonatal birth weight within each of the three embryo quality-based groups.
Results: The mean birth weight and the rate of preterm birth were similar between the three groups (p = 0.45 and 0.32, respectively). There were also no significant differences found in the vitrification comparative analysis between and within the groups with regard to birth weight.
Conclusion: Our results showed that a poor-quality embryo did not have a significant influence on a good-quality one regarding neonatal birth weight when transferred together.
Key words: Embryo quality, Birth weight, Frozen-embryo transfer, Fresh embryo transfer, Single embryo transfer, Double embryo transfer.
Basella alba, Grewia asiatica, Solanum nigrum and Ficus carica fruit extracts ameliorate the testicular histopathology induced by CCl4 exposure in albino mice: An experimental study
Authors: Nadia Ahmad Syeda , Raees Ahmad Khawaja , Abdullah Usma , Malik Fiza , Ali Rabiyah , Amir-ud-din Umara , Ali Kanwal Muhammad , Inayat Iram
Published: March 2022

Background: Carbon tetrachloride (CCl4) is extensively used in various industries and induces oxidative stress in humans. Unfortunately, it is one of the neglected potent male reproductive toxicants.
Objective: The present research reports the testicular histopathology of CCl4 and ameliorations by four medicinal fruit pulp extracts (FPEs) in mice.
Materials and Methods: Sixty male albino mice were divided into six groups (10/group) as per the following: 1. Vehicle control (Vc); 2. CCl4 (C); 3-6. CCl4+Basella alba (CBa), CCl4+Solanum nigrum (CSn), CCl4+Ficus carica (CFc) and CCl4+Grewia asiatica (CGa). Except for the control group, CCl4 (0.1 mL of 0.2 mL kg−1) was given to the animals in corn oil. The four plant extracts (0.1 mL each) were respectively given to the relevant FPE group animals for the next five consecutive days, while the animals in the Vc and CCl4 groups received water instead of FPE.
Results: The CCl4 exposure led to various histometric and histological alterations (loss of interstitial tissue and various dislodged tailless spermatids with enlarged heads) that were recovered in all except Solanum nigrum FPE mice post-treatment. The micrometric data of testicular sections also indicated significant decline in the number of spermatogonia, while the cross-sectional area of the sperm heads remained significantly higher in the CSn and C groups.
Conclusion: Except for Solanum nigrum, the three FPEs, especially Ficus carica, showed rehabilitative properties against CCl4 exposure-related modifications in testicular histopathologies.
Key words: Basella alba, Grewia asiatica, Solanum nigrum, Ficus carica, testis.
The Effect of Iran's Health Transformation Plan on Job Involvement of the Clinical Faculty Members in Ahvaz Jundishapur University of Medical Sciences
Authors: Gilavand Abdolreza , Mehralizadeh Yadollah
Published: March 2022

Introduction: Given the role of job involvement in job satisfaction and improving the organizational performance of the staff, the present study was conducted to evaluate the effect of Iran's Health Transformation Plan (HTP) on job involvement of the clinical faculty members.
Methods: This descriptive study was conducted in the academic year of 2018-2019 and in educational hospitals affiliated with Ahvaz Jundishapur University of Medical Sciences in Iran, and finally, 90 clinical faculty members participated in this study by using a convenience sampling method. To collect data, a researcher-made questionnaire was based on the standard Lodahl and Kejner's job involvement questionnaire. The data were analyzed using descriptive statistics (mean, standard deviation, percentage), inferential statistics (independent t-test and analysis of variance), and SPSS22 software.
Results: The results revealed that the level of Iran's Health Transformation Plan on job involvement of the clinical faculty members was moderate (48.73 ± 14.40).Variables such as gender, age, education, academic rank, employment history, and having a private clinic and hospital where faculty members work, did not have a significant effect on their job involvement.(P-value > 0.05)
Conclusion: The HTP is currently one of the most important and costly health care reforms in Iran, and for better success and the staff's satisfaction, it is recommended to pay more attention to effective and influential factors in improving and increasing job involvement of service providers, especially clinical faculty members in their periodic evaluation.
Understanding Health Insurance from the Perspective of an Ecosystem: A Systematic Review and Meta-Synthesis
Authors: Noori Hekmat Somayeh , Rahimisadegh Rohaneh , Mehrolhasani Mohammad Hossein , Jafari Sirizi Mohammad
Published: March 2022

Background: The health insurance ecosystem involves all the organizations and institutions which act as ecosystem actors in accordance with the objectives, values and functions of the ecosystem as its elements. Comprehensive understanding of the elements and actors of this ecosystem can be effective in improving its current status and in the future. Thus, the present study aimed to discuss the key elements (objectives, values and functions), as well as the actors of the health insurance ecosystem by a systematic review method.
Methods: This systematic review study was conducted in January 2021 using the six-step Walsh and Downe technique in the form of meta-synthesis. The question proposed a search strategy using the SPIDER framework, and the search was done in PubMed, Scopus, Web of Science ,Cochrane and Persian database of Magiran without considering a specific time and place. Content analysis method and MAXQDA 2020 were used to combine the findings. the Mixed Methods Appraisal Tool (MMAT) evaluation checklist version 2018 was used to evaluate quality of studies.
Results: 1410 articles were found in major databases, and 10 papers were found by manual searching using the search strategy. In addition, 612 duplicate records were removed from the search results after entering the results in EndNote X7 software. Ultimately, 9 studies reached the stage of quality evaluation and meta-synthesis. The selected studies were reviewed one by one, and their key concepts and themes were identified using content analysis method. Finally, the list of actors and key elements of the health insurance ecosystem was made.
Conclusion: Establishing fair participation and financial protection were identified as the most important key elements in the health insurance ecosystem, achieved through governance functions, resource supply, and service delivery in the context of an integrated and transparent structure. Applying governance is the most important role of ecosystem, forming the necessary participation and coordination between the actors in different roles, and regulating the interactions between them through mechanisms such as tariffs and the payment system. The role played by many actors with different roles or different roles by one actor in the ecosystem results in complexity and conflict of interest.
Assessment of Tools to Diagnose Cancer in Patients with Early Stage Breast Cancer: A Systematic Review
Authors: Pakdaman Mohsen , Dehghan Hamidreza , Ziadpoor Habibeh , Abolhasanizade Firoozeh , Namayandeh Seyedeh Mahdieh
Published: March 2022

Background: Breast cancer is an uncontrolled and unnatural proliferation of cells in different breast tissues. The first measure to diagnose breast cancer is an examination by a surgeon followed by mammography, sonography, sampling, and other diagnosing methods. Given that there are several methods to diagnose breast cancer, and most of them are quite expensive, the present systematic review compares the expenses and effectiveness of different methods to diagnose breast cancer.
Methods: The study was carried out as a systematic review through searching databases, i.e., PubMed, Web of Science, Magiran, Scopus, and Embase for articles published from March 1999 to May 31, 2017. The research articles regarding health technology assessment and economic assessment (n = 8) were examined.
Results: Generally, conducting MRI screening and digital mammography every six months after the age of 30 are proved to be the most efficient and economical methods to screen carriers of BRCA (BReast CAncer) mutated genes. Besides, implementing both the techniques simultaneously was more cost-efficient with BRCA1 compared to BRCA2. Some studies have revealed that genetic tests and Oncotype tests, in particular, were the most cost-efficient methods to diagnose the disease, especially in its early stages.
Conclusion: Consequently, indexing gene expression in individuals with BRCA gene mutation is revealed to more cost-efficient.
Factors that Affect the Level of Lower Limbs Amputation in Diabetic Foot: Educational Corner
Authors: Ghiasi Nezhad Saman , Moharrami Alireza , Hoseini Zare Nima , Moazen Jamshidi Mir Mansour , Mafi Amir Reza , Mortazavi Seyed Mohammad Javad
Published: March 2022

The article's abstract is not available.
Indonesian Muslim Tradition during COVID-19 Pandemic
Authors: Kusumawati Aditya , Indraswari Ratih , Handayani Novia
Published: March 2022

Background: The majority of Indonesians are Muslim (87%) scattered in each province. They celebrated Eid al-Fitr at the end of May 2020 along with the COVID-19 pandemic that has not ended yet. The tradition of celebrating Eid day is contradictive to the COVID-19 transmission prevention efforts that prohibit people from the crowd, prohibit having activities outside of their houses, and limit human mobilization. Even the president has imposed a ban on mudik Lebaran (coming back to hometown) due to the prediction of massive human migration. The handling of the COVID-19 pandemic requires participation of all parties, including the central government, regional governments, local leaders, the private sector, and the whole community. Objective: This study aims to describe the Indonesian Muslim tradition related to the prevention of the transmission of COVID-19 pandemic. Methods: This was quantitative research with a cross-sectional design. Data were collected a day before Eid day. There were 246 Muslims in Central Java province as respondents. Variables in this study were respondent characteristics (age, sex, educational level, occupation, and economic level) and Muslim Eid Al-Fitr tradition such as mudik tradition, Eid shopping needs, silaturahmi tradition, and Eid praying. This study also identified the respondents’ practice in preventing COVID-19 transmission. All variables were analyzed descriptively to explain how Muslims conducted their tradition during the COVID-19 pandemic. Results: COVID-19 pandemic caused most Muslims not to celebrate Eid as usual. They had to be far away from their families. On the other hand, the tradition to visit the tombs of the ancestors was also maintained by Javanese people and had become a habitual culture. Carelessness and disobedience against health protocols during a pandemic might bring fatal consequences to themselves and others. Conclusion: Most Muslims were discouraged from mudik, silaturahmi, and performing Eid prayer in a congregation in the mosque. They encountered difficulties to keep physical distancing due to people around did not exercise physical distancing for themselves.
THE EFFECTIVENESS OF THE DECOCTION OF RED BETEL LEAVES (PIPER CROCANTUM) AGAINST THE REDUCED SYMPTOMS OF FLUOR ALBUS IN ADOLESCENT GIRLS
Authors: Purwanti Rosa
Published: March 2022

Background: Fluor albus is excessive fluid from vagina that is not menstruation. To reduce the symptoms of fluor albus, non-pharmacological treatment from the decoction water of red betel leaves (Piper crocantum) was used in the present study. These red betel leaves (Piper crocantum) contain alkaloids that the green betel leaves do not have, and the alkaloids play a role as an antimicrobial agent. Besides, the red betel leaves have antiseptic power that is twice higher than the green betel leaves. The red betel leaves (Piper crocantum) also contain carvakrol which is anti-fungal and disinfectant, and it that can be used as an antiseptic medicine to maintain oral cavity health, cure fluor albus disease, and alleviate bad odor. Purpose: The present study aims to discover the effectiveness of the decoction of red betel leaves in reducing the fluor albus symptoms. Method: This study uses quasi-experimental research design with one group undertaking pre- and post-tests. It involved 20 adolescent girls of Al-Adzkia Sentul Boarding School in which the sample was taken using purposive sampling techniques. Further, a closed ended questionnaire is used to collect data, then analyzed using paired t-test. Result: The results showed a meaningful difference before being given treatment for 13.40. After treatment the value became 8.27 with a p-value < of α (0.005). Conclusion: The results this study indicated a decrease in symptoms of vaginal discharge after the use of red betel leaf decoction and recommended it to be used as a form of non-pharmacological therapy or traditional medicine in reducing fluor albus symptoms in adolescent girls.
ABNORMAL BLOOD LIPIDS LEVELS (DYSLIPIDEMIA) TREATMENT WITH ACUPUNCTURE METHOD
Authors: Rinjani Anissa Maulina , Septriana Maya , Herawati Lilik
Published: March 2022

Background: Dyslipidemia is an abnormal lipid metabolism characterized by an increase in total cholesterol, LDL (Low-Density Lipoprotein), triglycerides (TG), and a decrease in HDL (High-Density Lipoprotein). Increased levels of total cholesterol, TG, LDL, and decreased HDL levels can increase the risk of cardiovascular disease. According to TCM, dyslipidemia is categorized into “Tan Zheng” (phlegm syndrome), “Shi Zuo” (damp retention), “Xuan Yun” (vertigo), and “Fei Pang” (obesity). Purpose: The purpose of this review is to analyze the literature study on TCM within the treatment of dyslipidemia with different acupuncture methods and points. The primary data search was conducted using online e-resources (Google Scholar, Proquest, and Pubmed). Review: The results of the study should include at least one of the outcomes indicators for total cholesterol, TG, LDL, and HDL. The result there were 20 journals consisting of studies that used several acupuncture methods, manual  acupuncture  (AM),  electroacupuncture  (EA), moxa (MOK), auricular acupuncture (AA), Cupping (CUP), and found additional interventions  such as nutritional  interventions, and exercise; body points often used are Zusanli  (ST 36),  Fenglong (ST 40), Quchi (LI 11), Daheng (SP15), Zhongwan (CV 12), Qihai (CV 6), Guanyuan (CV 4), Sanyinjiao  (SP  6), Shenque  (CV  8),  Tianshu  (ST  25), and therefore for AA are Spleen (CO 13), Stomach (CO 4),  Shenmen (TF 4), and hunger point. Twenty journals showed a decrease in total cholesterol, TG, LDL levels, and an increase in HDL levels. Conclusion: In conclusion, all types of acupuncture methods can reduce total cholesterol, TG and LDL levels, and increase HDL levels.
The Development Model of Japanese Cold Chain Logistics: The Example of Seafood Transportation
Authors: Ren Fangtao
Published: March 2022

This paper mainly analyzes the value-added mechanism in the supply chain and the experience of cold chain logistics development based on the cold chain logistics transportation of seafood in Japan. The support and protection of the law for cold chain logistics, as well as the development of the degree of informationization and the construction of infrastructure facilities are studied from the government level. On this basis, certain problems are found, for example, the lack of management level, the lack of excellent talent reserve, the backwardness of infrastructure facilities, and the low degree of information technology, etc. Some rationalization suggestions are provided for the development of seafood transportation and the development of the supporting logistics supply chain system in China.
Cannabis sativa CBD Extract Shows Promising Antibacterial Activity against S. typhimurium and S. newington
Authors: Gildea Logan , Ayariga Joseph , Ajayi Olufemi , Xu Junhaun , Villafane Robert , Samuel-Foo Michelle
Published: March 2022

Products derived from Cannabis sativa have gained increased interest and popularity. As these products become common amongst the public, the heath and potential therapeutic values associated with hemp have become a premier focus of research. While the psychoactive and medicinal properties of Cannabis products have been extensively highlighted in literature, the antibacterial properties of CBD have not been explored in depth. This research serves to examine the antibacterial potential of CBD against Salmonella newington and Salmonella typhimurium. In this study we observed bacterial response to CBD exposure through biological assays, bacterial kinetics, and fluorescence microscopy. Additionally, comparative studies between CBD and ampicillin were conducted against Salmonella typhimurium and Salmonella newington to determine comparative efficacy. Furthermore, we observed potential resistance development of our Salmonella spp. against CBD treatment.
Релаксация заряда потока электронов в воздушной среде
Authors: Воронин Федор Николаевич , Voronin Fedor Nikolaevich , Марков Михаил Борисович , Markov Mikhail Borisovich , Паротькин Сергей Владимирович , Parot'kin Sergey Vladimirovich
Published: March 2022

Рассмотрен процесс релаксации объемного электрического заряда, формирующегося при рассеянии быстрых электронов в воздушной среде. Носителями заряда являются отрицательные ионы, образующиеся при прилипании термализованных электронов к молекулам кислорода. Построена математическая модель дрейфа ионов в электрическом поле, основанная на законе непрерывности заряда и уравнениях Максвелла. Алгоритм численного решения уравнений модели основан на методе частиц. Выполнена численная оценка времени релаксации объемного заряда.
survival rate comparison of non small cell lung carcinoma patients who are given by epidermal growth factor receptor-tyrosin kinase inhibitor and those given by first-line chemotherapy treatment
Authors: Nyambe Hasan , Santoso Arif , Tabri Nur Ahmad , Iskandar Harun , Ilyas Muh , Wiriyansyah Edward Pandu
Published: March 2022

Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamous and squamous. Non-small cell lung cancer of non squamous types consist of adenocarcinoma and large cell carcinoma. Currently, lung cancer therapy is highly developed of chemotherapeutic agents to targeted therapy especially EGFR-TKI. This study aims to assess the survival rate of NSCLC patients who receive first line chemotherapy and those who recieve EGFR-TKI therapy at Wahidin Sudirohusodo hospital. Methods. This study is a retrospective study between 2017 to 2019 from the medical records of NSCLC patients who receive first-line chemotherapy and thise who recieve EGFR-TKI. Patients with platinum-based chemotherapy and EGFR-TKI with gefitinib therapy 1x250 mg/day or erlotinib 1x150mg/day and or afatinib 1x40 mg/day. Survival rate assessed from start to erect the diagnosis until the patient dies or when the  study is     discontinued. Result. From 239 subject of NSCLC patients consisted of 135 patients who receive first-line chemotherapy, and 104 patients are treate with EGFR-TKI. Based on the characteristics of the patients, most are more than 40 years old (chemotherapy 124 (91.9%) and EGFR-TKI 101 (97.1%) with the male gender that dominates (chemotherapy 98 (72.6%), EGFR-TKI 64 (61.5%). Smoking patients who received first-line chemotherapy are 65.2% and 61.5% of EGFR-TKIs with chemotherapy highest IB (severe IB 28.9%) and for EGFR-TKI (moderate IB are 26.9%). 73.2% of adenocarcinoma histology type with a predominance of stage IV 86.6% (83.7% for chemotherapy and EGFR-TKI 90.4%). Survival rate of patients are 98,7% for 6 months survival, 1 year survival rate is 94.1% and 2 years survival rate of 24.3%. Median survival patients who receiving EGFR-TKI longer than they received first- line chemotherapy (21 months versus 20 months). The 18 months PFS showed that patients treated with EGFR-TKI were 15 months, while patients receiving chemotherapy was 11 months. (P 0.000). Conclusion. Survival rates in NSCLC patients with EGFR-TKI therapy had significantly the highest survival rates compared with all other chemotherapy. Progression was faster in patients with first-line chemotherapy than EGFR-TKI. The factors that most influence the survival rate is type of therapy with p value<0.05.
Evaluating cross-shore sediment grain size distribution, sediment transport, and morphological evolution of a nearshore berm at Fort Myers Beach, Florida
Authors: Zarillo Gary , Ramos Sara , Effinger Kristopher , Becker Kristen , Watts Irene , Brutsché Katherine , McFall Brian , Krafft Douglas
Published: March 2022

Navigation channels are periodically dredged to maintain safe depths. Dredged sediment was historically placed in upland management areas or in offshore disposal areas. Florida state law prohibits placement of beach fill sediment that contains more than 10% by weight of silt and clay, which is typically a characteristic of dredged material. An alternative is placement in a nearshore berm. Some potential benefits of nearshore berms include wave energy dissipation, reduced cost of dredging and shore protection, and possible onshore movement of the berm material. This study considers sediment distribution, morphological evolution, sediment transport, and shoreline trends along Fort Myers Beach, Florida, related to the nearshore berm constructed in August 2016. Due to timing of the field study, this report also includes information on the influence of a major hurricane that impacted the area. The overall conclusion of this study is that the dredge-sourced sediment in the berm performed as expected. Within 2 years, the berm adjusted to the shoreface environment, maintained a large part of its original volume, and contributed to protection of the beach and shoreline. The impact of Hurricane Irma included a shift in sediment textures and a large but temporary increase in shoreface sediment volumes.
Predictors of severe labor pain: prospective observational study.
Authors: Romanenko Anastasiia , Kuchyn Iurii , Govsieiev Dmytro , Bielka Kateryna
Published: March 2022

Introduction: Pain during childbirth is a complex and subjective experience that every mother experiences differently [1]. The degree of a woman's suffering in childbirth depends on the intensity of labor pain and many indirect factors [2]. Complex interrelated effects on labor pain are limited by the little number of studies available. That is why it is necessary to determine the probable factors that may affect the intensity of pain. In accordance with this, determining predictors of the intensity of pain during vaginal delivery remains an important issue for the maternity health policy.Aim: Investigate predictors of severe labor pain.Method: A prospective observational study was conducted in the period from December 2020 to May 2021 at the Kyiv City Maternity Hospital №5 (Kyiv, Ukraine). Logistic regression was used to measure the influence of risk factors on the probability of severe labor pain.Results: The examined predictors were derived from mothers` self-report of overall childbirth. 366 women took part in research, 282 of them rated their pain by ≤ 60 mm visual analog scale (VAS), while 84 patients reported their pain by ≥70 mm VAS. The study identified predictors that reduce the risk of severe labor pain, such as a woman's prenatal health (namely, a healthy prenatal woman) (OR 0.0967 [95% CI 0,0344 - 0,2719], p=0,0001), attendance of maternal school (OR 0.0978 [95% CI 0.0541 - 0.1767], p<0,0001), doula`s help (OR 0,1266 [95% CІ 0,0711 - 0,2255], p<0,0001) and feeling of control over pain in labor (OR 0,0176 [95% CІ 0,0086 - 0,0359], p<0,0001). In addition, predictors such as first delivery (OR 1.67 [95% CI 1.0240 - 2.7387], p=0,04) and prenatal anxiety (OR 9.1277 [95% CI 5.2973 - 15.7276], p<0,0001) in contrast to the factors listed above, increase the risk of severe labor pain. Conclusion: Significant predictors of severe labor pain were identified through this study. The findings are useful in the maternal care system by focusing on early prevention of treatment labor pain. ClinicalTrials.gov: Retrospectively registered on February 23, 2022, NCT05226208
Suppressing circ_0008494 inhibits HSC s activation by regulating the miR-185-3p/ Col1a1 axis
Authors: Li Binbin , Zhou Jiaming , Luo Yuanyuan , Tao kegong , Zhang Lifen , Lin Yong , Zeng Xing , Yu Hongyu
Published: March 2022

Background
Because of its viral nature and the increasingly metabolic chronic liver diseases, hepatic fibrosis (HF) has become a major challenge to global health. However, there are still no approved effective therapies for HF. Circular RNAs (circRNAs) have emerged as new potential targets of liver diseases. Thus, this research aims to clarify the role of circ_0008494 in liver fibrosis and reveal its mechanism.
Methods
circRNA profiles were screened by RNA sequencing and the location of circ_0008494 was confirmed by fluorescence in situ hybridization assay in human liver fibrosis tissues. Bioinformatics analysis was used for result prediction and dual luciferase reporter, together with AGO-RIP and biotin-coupled miRNA capture assays, were used to determine miR-185-3p/collagen type I alpha 1 chain (Col1a1) as the target of circ_0008494. A stable circ_0008494-interfering cell line of the hepatic stellate cells (HSCs) was constructed and used to determine the regulatory mechanism of circ_0008494/ miR-185-3p/ Col1a1 axis.
Results
Hsa_circ_0008494 was significantly over-expressed and uniquely located at the cytoplasm of HSCs in human HF tissues. Together, dual luciferase reporter, AGO-RIP and biotin-coupled miRNA capture assays validated that circ_0008494 acted as a sponge of miR-185-3p. Rescue assays demonstrated suppressing circ_0008494 could inhibit HSCs’ activation, proliferation, migration and promote their apoptosis through miR-185-3p. In particular, the fibrosis indicator, Col1a1, was predicted as the direct target of miR-185-3p and the suppression of circ_0008494 inhibited the expression of Col1a1 by releasing miR-185-3p.
Conclusions
Knocking down circ_0008494 ameliorated fibrosis through the miR-185-3p/Col1a1 axis. circ_0008494 could be a promising treatment target for hepatic fibrosis.
The Impact of the September 7th 2017 Earthquake on the Businesses of the Municipal Market of Juchitán De Zaragoza Due to Property Damage
Authors: Soto David Ortiz , Angulo Eduardo Reinoso , Ruiz Jorge Alberto Villalobos
Published: March 2022

Earthquakes of great intensity often affect businesses because the buildings where they operate are severely damaged, in this sense, the municipal market of Juchitán de Zaragoza represents an interesting case study. This investigation identifies the damage to property during the 8.2 Mw earthquake that occurred on September 7th, 2017, observing that the short column problem occurred in most of the columns, a settlement and shear failures in beams and non-structural walls, and later the structural and non-structural rehabilitation are detailed. Likewise, a statistical report is presented on a survey applied in November 2020 to 165 businesses established in the market to evaluate the business impact of the loss of the building’s operability due to the destructive event. According to the results obtained, only 4.24% of the economic units surveyed did not have direct losses due to the earthquake, on the other hand, 45.46% could not operate for more than a month and 33.94% considered that they stopped earning more than $ 3,000 MXN ( $ 160 USD) during the time of absolute stoppage of its activities.
Effect of annual hospital admissions of cardiac out-of-hospital cardiac arrest patients on prognosis following cardiac arrest
Authors: Tsuchida Takumi , Ono Kota , Maekawa Kunihiko , Hayamizu Mariko , Hayakawa Mineji
Published: March 2022

Background: Although the prognosis of patients treated at specialized facilities has improved, the relationship between the number of patients treated at hospitals and prognosis is controversial and lacks constancy in those with out-of-hospital cardiac arrest (OHCA). This study aimed to clarify the effect of annual hospital admissions on the prognosis of adult patients with OHCA by analyzing a large cohort.Methods: The effect of annual hospital admissions on patient prognosis was analyzed retrospectively using data from the Japanese Association for Acute Medicine OHCA registry, a nationwide multihospital prospective database. This study analyzed 3,632 of 35,754 patients hospitalized for cardiac OHCA at 86 hospitals. The hospitals were divided into tertiles based on the volume of annual admissions. The effect of hospital volume on prognosis was analyzed using logistic regression analysis with multiple imputation. Furthermore, three subgroup analyses were performed for patients with return of spontaneous circulation (ROSC) before arrival at the emergency department, patients admitted to critical care medical centers, and patients admitted to extracorporeal membrane oxygenation-capable hospitals. Results: The 30-day survival rate after admission was not correlated with hospital volume in all cardiac OHCA patients and subgroups. However, the frequency of favorable neurological outcomes in cardiac OHCA patients with ROSC before arrival at the emergency department at high-volume centers was higher than those at medium- and low-volume centers. Conclusion: Hospital volume did not significantly affect the prognosis of adult patients with cardiac OHCA. However, transport to a high-volume hospital may improve the neurological prognosis in cardiac OHCA patients with ROSC before arrival at the emergency department.
Lingyuanfructus, A Unique Fossil Gymno-Angiosperm Catches the Long Sought Snapshot of Plant Evolution
Authors: Wang Xin
Published: March 2022

The Yixian Formation in northeast China is worldwide famous for its fossils of early angiosperms, which play a key role in the study of early evolution of angiosperms. Despite all efforts, the morphological gap between angiosperms and gymnosperms remain as conspicuous as ever, due to lack of a fossil plant intermediate between angiosperms and gymnosperms. It is well-known that angiosperms are distinguished from gymnosperms, which have naked ovules, by their enclosed ovules. A plant intermediate between angiosperms and gymnosperms should have both enclosed as well as naked ovules in the same plant. Although some extant angiosperms may have their ovules not fully enclosed and some extant gymnosperms have their seeds enclosed, none of fossil or living plants has its ovules naked and enclosed in the same plant hitherto. However, Darwinism does expect such a chimeric existence. Here I report such a long-expected plant, Lingyuanfructus hibrida gen. et sp. nov, from the Yixian Formation (Lower Cretaceous). The unique feature of Lingyuanfructus is that, in a single fossil, the ovules are both naked and enclosed, exactly the expected chimera filling the huge morphological gap between angiosperms and gymnosperms.
Osteochondroma of the scapula: An uncommon site of presentation in the elderly: A case report
Authors: (MS) . Prof. Ravi Sauhta , (MS MRCS) Dheeraj Makkar
Published: March 2022

Osteochondromas are benign bone tumors that mainly affect the metaphysis of long bones. We describe a 50-year-old patient who presented with a ventral scapular osteochondroma that limited her shoulder movement and caused tumor-induced paresthesia during sleep. The swelling was accompanied by pain and an inability to execute her professional obligations for the preceding four months. There were no neurological abnormalities. CT scan revealed a mushroom-shaped mass with cortical and medullary components near the scapula's lateral angle. We intended to do the surgery in the lateral decubitus position and under general anesthesia via the axillary approach. We describe a unique location and age range in which osteochondroma manifests. Because the risk of malignancy grows with age, we underline that osteochondroma should be considered a differential diagnosis in both unusual locations and age groups. Secondly, patients should be monitored clinically and radiographically following excision.
KDM3A silencing effectively inhibits bone turnover and metastasis development in breast cancer
Authors: Yao Juan , Han Yuanxing , Maimaiti Nueryemu , Sun Yue
Published: March 2022

Objective: Bone metastasis is the main cause of death in patients with breast cancer (BCa). Lysine demethylase 3A (KDM3A) plays an important role in metastatic breast cancer. In our study, we aimed to detect the expression and invasion of KDM3A in bone metastases from breast cancer, and provide an important theoretical basis for effective prevention and treatment of BCa.Methods: MDA-MB-231 breast cancer cells were transfected with KDM3A shRNA lentivirus to knock down KDM3A level. The biological function of KDM3A was examined in MDA-MB-231 breast cancer cells, MCF-10A breast epithelial cells and nude mice with bone metastasis.Results: Silencing KDM3A significantly inhibited the proliferation, metastasis and invasion of BCa cells and promoted apoptosis in both in vivo and in vitro experiments.Conclusion: siRNA-mediated silencing of KDM3A can inhibit the proliferation, invasion and promote apoptosis of BCa cells.
The SAFE study: Stress and Fatigue control by Exercise: Acute and long-term effects of aerobic exercise in lactating employed mothers
Authors: Basyouny Sara , Botla Afaf M. , Atef Hady , Hussien Hossam El-Dien , Shehata Mai Ali
Published: March 2022

Background: Stress and fatigue experienced by lactating employed mothers could affect mothers’ and babies' mental and physical health detrimentally. Aerobic exercise is known to control stress and fatigue, but the dosages of the exercises needed to maintain long-term effects are under investigation. This study aimed to investigate the acute and long-term effects of aerobic exercise on controlling stress and fatigue in lactating employed mothers. Methods: This randomized control study involved sixty lactating employed mothers who were suffering from stress and fatigue. They were divided into two groups. Group A received five sessions of 30-minute aerobic training on a treadmill/week, in addition to lifestyle modification advice for 6 weeks. Group B received the same lifestyle routine advice for the same duration without being trained. Assessment of stress and fatigue levels were done before, after 6 weeks, and after 6 months from the baseline assessments using the Perceived Stress Scale (PSS-10) and Fatigue Assessment Scale (FAS) respectively. Results: Post-six weeks comparison within and between both groups showed a significant decline in PSS-10 and FAS in group A compared with group B (p < 0.001), however after six months of follow up there were statistically significant effects within groups only (p<0.05), and no statistically significant difference between groups at both variables as (p>0.05). Conclusion: Aerobic exercises for 6 weeks can induce an acute but not long-term effect on the stress and fatigue control in lactating employed mothers. Future research is needed to tailor the exercise prescription needed to maintain training long-term benefits.Trial registration: Clinical Trials Registration. Registered 4 June 2021, (Registry ID: NCT 04913558)
Abolished TNF-α is crucial for the maintenance of B10 cells subsets in Psoriasis development
Authors: Zheng Yi , Gao Yu , Ji Yanhong
Published: March 2022

Background: Psoriasis is a common chronic skin disease characterized by epidermal proliferation and inflammation. Tumor necrosis factor α (TNFα) has a high degree of pro-inflammatory and can cooperatively regulate the pathogenic effect of other cytokines. TNFα inhibitors have shown effective in treating plaque psoriasis. IL-10 is closely related to the severity of psoriasis. Regulatory B cells (Bregs) that produce IL-10 are identified as negative regulators of the immune response, also known as B10 cells. At present, the contribution of B10 cells to the pathogenesis of psoriasis is unclear. Therefore, we used gene knockout mice, combined with data analysis of clinical psoriasis patients, to explore the role of TNFα and IL-10 regulating B10 cell function in the occurrence and development of experimental psoriasis evidence for the psoriasis clinical diagnosis and treatment.Results: The plasma inflammatory cytokine levels from psoriasis patients were higher than those in healthy controls. Impaired mature and immature B10 cell subsets in the peripheral of psoriasis patients, and both B10 and B10 progenitor cells were correlated with the pathogenesis of psoriasis after Tretinoin (Vitamin A Acid, Retinoids) treatment. Through the psoriasis models in TNFα knockout and wild-type mice induced by IMQ, It was found that the psoriatic lesions in TNFα knockout mice were slighter than those in wild-type mice, and the proportion of B10 and B10 precursor cells in the spleen of TNFα knockout mice decreased before and after IMQ induction. The expression level of IL-10 in the skin tissue of the TNFα KO mice model was significantly decreased in contrast to WT control after IMQ treatment. Conclusions: Our study was to explore the effect of the imbalance between B10 cells and TNFα on the pathogenesis of psoriasis from psoriatic patients' B10 cells and B10 precursor cells, combined with the psoriatic animal model. The mechanism by which TNFα affects B10 cells and B10 progenitor cells still need further study.
Carbohydrate utilization by the gut microbiome determines host health responsiveness to whole grain type and processing methods
Authors: Smith Caroline , Haute Mallory J. , Xian Yibo , Munoz Rafael R. Segura , Schmaltz Robert J. , Ramer-Tait Amanda E. , Rose Devin J.
Published: March 2022

Background: Grain processing, grain type, and carbohydrate utilization (CU) by the microbiome each individually influence the health benefits of whole grains. However, little is known about how these factors interact to influence host health outcomes. Therefore, two whole grains, brown rice and whole wheat, and two processing methods, boiling (porridge) and extrusion, were studied for their effects on host metabolic outcomes in mice harboring human microbiomes previously shown in vitro to have high or low CU. Results: Mice carrying either microbiome experienced increases in body weight and glycemia when consuming Western diets supplemented with extruded grains versus porridge. However, mice with the high CU but not low CU microbiome also gained more body weight and fat over time and were less glucose tolerant when consuming extruded grain diets. Cluster analysis of both host metabolic health parameters and fecal microbiota changes during feeding revealed that mice consuming extruded diets clustered seprately from those consuming the other diets only when harboring the high CU microbiome, suggesting that the exacerbated negative host health outcomes associated with extrusion were related to changes in microbiota composition. In partiuclar, the high CU microbiome mice consuming an extruded diet had altered abundances of Lachnospiraceae and Ruminococcaceae, which contributed to elevated sugar degradation and colonic acetate production. The ASVs associated with the extruded and porridge diets in this in vivo study were not the same as those identified in our prior in vitro study; however, the predicted functions were highly correlated.Conclusions: Grain processed using severe extrusion, regardless of grain type, worsened host metabolic health compared with grain processed to porridge. Mice harboring either microbiome responded to the whole grain diets similarly, except the high CU microbiome mice exhibited exacerbated effects due to excessive acetate production, indicating that CU by the microbiome is linked to host metabolic health outcomes. Importantly, the metabolic phenotypes observed in the present study were predictable based on the results from our in vitro study. Our work demonstrates that a greater understanding of food processing effects on the microbiome is necessary for developing foods that promote rather than diminish host health.
Bullous pemphigoid anti-BP180-NC16A autoantibody reactivity in healthy individuals is associated with marked hypovitaminosis D and Th2-like cytokine predominance
Authors: Tukaj Stefan , Bieber Katja , Prüßmann Wiebke , Prüßmann Jasper N. , Schmidt Enno , Zillikens Detlef , Ludwig Ralf J. , Kasperkiewicz Michael
Published: March 2022

Autoimmune bullous disease autoantibodies, particularly including bullous pemphigoid (BP)-related anti-BP180-NC16A IgG, have been reported in a small subset of healthy individuals, but information about associated factors is lacking. We hypothesized that an abnormal status of immunomodulatory vitamin D could play a role in anti-BP180-NC16A autoantibody reactivity in healthy persons. In addition, we aimed to evaluate the cytokine profile associated with these autoantibodies. Plasma samples from 34 anti-BP180-NC16A IgG-reactive and 85 anti-BP180-NC16A IgG-negative healthy blood donors were tested for levels of 25-hydroxyvitamin D [25(OH)D] and a wide range of cytokines (IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-13, IL-17A, IL-17F, IL-21, IL-22, IFN-γ, and TNF-α). We observed that anti-BP180-NC16A IgG-reactive healthy subjects had significantly lower plasma 25(OH)D levels and about a two-fold higher rate of vitamin D deficiency (< 20 ng/ml) compared to anti-BP180-NC16A IgG-negative healthy persons. In addition, anti-BP180-NC16A IgG-positive samples were characterized by significantly higher levels of IL-2, IL-5, IL-9, IL-10, and IL-13. Our results indicate that healthy individuals with BP autoantibody reactivity share similarities with BP patients regarding the vitamin D status and cytokine profile (i.e., marked hypovitaminosis D and Th2 predominance), which may have pathophysiologic and treatment (i.e., early/prophylactic vitamin D supplementation) implications.
Key Attributes of Michelin 3-star Restaurants Experiences: Evidence from TripAdvisor
Authors: Saydam Mehmet Bahri , Arıcı Hasan Evrim , Olorunsola Victor Oluwafemi
Published: March 2022

Consumers can share User Generated Content on social media sites like TripAdvisor, which allows customers to track their contentment and displeasure. These activities are an important form of electronic word-of-mouth that might affect other customers' purchasing decisions. Hence, utilizing User Generated Content from an online platform, this study attempts to investigate guest' experiences in Michelin 3-star restaurants in the United States. Broadly speaking goal of the study was to identify the key aspects of Michelin 3-star restaurant experiences and see if they differed depending on the age and nationality of the travelers. Content analysis approaches were used to examine a sample of 1,032 customer online reviews. After computer-assisted qualitative data analysis identified the dominant themes, subsequent qualitative analysis identified the important narratives connected with Michelin 3-star restaurant experiences using Leximancer software. The findings show that customers are exceedingly pleased with their Michelin 3-star dining experiences. "Food," "chefs," "restaurant," "wine," "staff," and "price" are the major motives that run across the dominant narratives. The findings provide valuable perspectives into guests' overall experiences based on social media data and make it easier to identify the primary themes associated with the guests' gender and nationality
A decision making algorithm for inherited retinal dystrophies, caused by biallelic mutations in the RPE65 gene, in the clinical practice of an ophthalmologist
Authors: Saidasheva E. I. , Kadyshev V. V. , Brzheskiy V. V. , Malinovskaya N. A. , Shefer K. K.
Published: March 2022

Inherited retinal dystrophies (IRD) include a wide range of genetically and phenotypically heterogeneous diseases that lead to progressive loss of vision. With the development of gene therapy, it has become possible to treat two forms of IRD caused by biallelic mutations in the RPE65 gene: isolated retinitis pigmentosa (IRP) type 20 and Leber's congenital amaurosis (LCA) type 2. These nosologies are included in the list of orphan diseases of the Russian Ministry of Health. The success factor for the use of IRD gene therapy is the early stage of the disease, when the viability of retinal cells is preserved. An interdisciplinary approach to diagnostics makes it possible to timely establish the clinical and genetic variant of IRD and refer the patient to targeted therapy. Therefore, at a joint meeting of the Council of Experts of the North-Western Federal District of the Russian Federation, which included ophthalmologists and medical geneticists, a scheme for managing patients with IRD was accepted, including the stages of clinical and functional ophthalmological examination and molecular genetic testing. In addition, regional centers of expertise for IRD were approved in two federal medical institutions in St. Petersburg, whose task is to optimize the quality of diagnosing patients with IRP and LCA.
Primary choroidal melanoma followed by two metachronous ipsilateral ocular metastases
Authors: Finger P. T. , Yin C. T. , Pavlick A. C. , Farhat N.
Published: March 2022

Purpose. To describe two ipsilateral, metachronous, ocular choroidal melanoma metastases.Material and methods. A 64-year-old choroidal melanoma patient was initially treated with palladium-103 ophthalmic plaque brachytherapy which induced local control of the primary cancer. Seven years later, ophthalmic findings of a second, ipsilateral, discrete choroidal melanoma prompted restaging which revealed new hepatic and nodal metastases. Systemic immunotherapy (ipilimumab 3 mg/kg with nivolumab 1 mg/kg IV every 3 weeks 4 doses) resulted in intraocular tumor regression and was followed by maintenance nivolumab 480 mg IV every 4 weeks with follow-up ophthalmic examinations.Results. Three years after initiation of systemic immunotherapy, the patient was found to have a second ipsilateral local recurrence of choroidal melanoma. It presented with retinal detachment, uveitis, and optic neuritis. Then, due to its anterior uveal location, extrascleral tumor extension was amenable to a diagnostic biopsy. Overall, 3 years after onset of metastatic uveal melanoma and 2 months after her second ocular metastasis, the patient died. This was 10 years after the initial diagnosis of choroidal melanoma.Conclusions. Metastatic choroidal melanoma can present twice in the same eye as the primary tumor. Ophthalmic and systemic examinations allowed for immunotherapy to affect initial systemic regression, vision sparing, and globe salvage.