bluuebunny/crossref_metadata_2025 huggingface dataset:
mGluR5 in Astrocytes in the Ventromedial Hypothalamus Regulates Pituitary Adenylate Cyclase-Activating Polypeptide Neurons and Glucose Homeostasis
Authors: Meng Alice , Ameroso Dominique , Rios Maribel
Published: July 2023

The ventromedial hypothalamus (VMH) is a functionally heterogeneous nucleus critical for systemic energy, glucose, and lipid balance. We showed previously that the metabotropic glutamate receptor 5 (mGluR5) plays essential roles regulating excitatory and inhibitory transmission in SF1+neurons of the VMH and facilitating glucose and lipid homeostasis in female mice. Although mGluR5 is also highly expressed in VMH astrocytes in the mature brain, its role there influencing central metabolic circuits is unknown. In contrast to the glucose intolerance observed only in female mice lacking mGluR5 in VMH SF1 neurons, selective depletion of mGluR5 in VMH astrocytes enhanced glucose tolerance without affecting food intake or body weight in both adult female and male mice. The improved glucose tolerance was associated with elevated glucose-stimulated insulin release. Astrocytic mGluR5 male and female mutants also exhibited reduced adipocyte size and increased sympathetic tone in gonadal white adipose tissue. Diminished excitatory drive and synaptic inputs onto VMH Pituitary adenylate cyclase-activating polypeptide (PACAP+) neurons and reduced activity of these cells during acute hyperglycemia underlie the observed changes in glycemic control. These studies reveal an essential role of astrocytic mGluR5 in the VMH regulating the excitatory drive onto PACAP+neurons and activity of these cells facilitating glucose homeostasis in male and female mice.

SIGNIFICANCE STATEMENTNeuronal circuits within the VMH play chief roles in the regulation of whole-body metabolic homeostasis. It remains unclear how astrocytes influence neurotransmission in this region to facilitate energy and glucose balance control. Here, we explored the role of the metabotropic glutamate receptor, mGluR5, using a mouse model with selective depletion of mGluR5 from VMH astrocytes. We show that astrocytic mGluR5 critically regulates the excitatory drive and activity of PACAP-expressing neurons in the VMH to control glucose homeostasis in both female and male mice. Furthermore, mGluR5 in VMH astrocytes influences adipocyte size and sympathetic tone in white adipose tissue. These studies provide novel insight toward the importance of hypothalamic astrocytes participating in central circuits regulating peripheral metabolism.
Advances in historical wood consolidation and conservation materials
Authors: Wang Qi , Feng Xinhao , Liu Xinyou
Published: July 2023

Wood is an indispensable renewable material for national economic development. As a bio-organic material, wood is subject to deterioration due to climatic, biological, and chemical factors, which greatly limit the advantages of wood products and increase the difficulty of conserving historical wood. To preserve the historical and cultural heritage, extend the historical life of ancient wooden structures, and promote the efficient and sustainable utilization of wood resources, this paper provides an overview of the main degradation and destruction forms and biochemical changes of wood in ancient architecture, unearthed relics, and antique ship wood from the perspective of wooden structure, historical applications, and their forms of destruction. The conservation strategies and consolidation methods of ancient wood are reviewed, with emphasis on the summary and analysis of the properties and uses of different consolidation materials and their methodological characteristics for the conservation of historical wood. In the context of the development of biomaterials, polymer chemistry and nanotechnology, biomass nanocomposites are applied gradually in the field of consolidation. To provide a strong basis for the effective use of reinforced wood, this paper presents the theoretical foundation for the research and development of green, efficient, and environmentally friendly wood consolidation and protection technologies.
Classification of Port Systems for Port Competitiveness
Authors: Navarro Fabiola Cruz , Carvajal Yadit Rocca , Quiñones Alberto Miguel Vizcarra , Agama Pedro Pompeyo Gabriel Asca , Cristóbal Yta Zunilda Olortegui- , Mejía Percy Junior Castro
Published: July 2023

The general objective of the research was to classify port systems for competitiveness by implementation criteria, continents and port functional competitiveness indicators. This research used the qualitative approach and was applied. The thematic narrative research design due to the variety of information used in reference documents based on the topic of classifying port systems for competitiveness. A classification with 18 criteria was constructed by evaluating their fulfillment in the different port systems based on the literature reviewed. They were also classified by level of implementation, by countries in which they have been implemented, and by port competitiveness indicators. The port community and the automatic identification system are focused on improving the flow of information, while the terminal operation system, the automated gate system and the truck appointment system are focused on optimizing the operations performed at ports.
INTEGRASI KOMPETENSI KEBAHAGIAAN DALAM PENGEMBANGAN SIKAP SPIRITUAL DAN SOSIAL SISWA
Authors: Khairunnisa Muthia Fadhila , Salsabilla Tiara , Apsari Nurliana Cipta
Published: July 2023

Abstract. Education curriculum is one of the most important aspects in the learning process. In Indonesia’s 2013 Curriculum (K13), spiritual and social traits become one of the three graduation competencies for students. However, character development and planting a sense of joy in learning for students have not become the main focus in Indonesian education. The government of Delhi, India, developed an innovation called Happiness Curriculum, where it includes three Happiness Competencies, which are: mindfulness, critical thinking and reflection, and social-emotional skills. This study is important because developing the character of critical, mindfulness and able to self-reflection will assist the Indonesian young generation to be more prepared to address challenges and issues of the future. This research aims to identify the urgency and how can the Happiness Competencies be integrated into the curriculum in Indonesia to increase the spiritual and social traits competency for students at school. The method used is literature review. The result shows that the Happiness Competencies based on the Happiness Curriculum from Delhi, India, can be integrated starting from the teacher and the surrounding environment that supports the said transformation, considering that mental health at school is one of the issues that should become the concern of actors in the education sector. Keyword: Education, curriculum, happiness competency, spiritual traits, social traits. Abstrak. Kurikulum pendidikan merupakan salah satu aspek penting dalam proses pembelajaran. Dalam Kurikulum 2013 (K13) di Indonesia, sikap spiritual dan sosial menjadi salah satu dari tiga standar kompetensi kelulusan siswa. Namun, pengembangan karakter dan penanaman rasa senang belajar kepada siswa belum menjadi fokus utama dalam pendidikan Indonesia. Pemerintah Delhi, India, mengembangkan inovasi bertajuk Happiness Curriculum yang mencakup tiga Kompetensi Kebahagiaan, yakni: mindfulness, critical thinking, and reflection, serta social-emotional skills. Penelitian ini bertujuan untuk mengidentifikasi urgensi serta bagaimana Kompetensi Kebahagiaan tersebut dapat diintegrasikan kedalam kurikulum di Indonesia guna meningkatkan kompetensi sikap spiritual dan sosial siswa di sekolah. Penelitian ini penting karena pengembangan karakter siswa yang kritis, mampu merefleksikan diri dan memiliki kemampuan mindfulness dapat membantu generasi muda Indonesia menjadi generasi yang lebih siap menatap tantangan di masa depan. Metode yang digunakan ialah studi kepustakaan. Hasil penelitian menunjukkan kompetensi kebahagiaan berdasarkan Happiness Curriculum dari Delhi, India, dapat diintegrasikan dimulai dengan guru dan lingkungan sekitar yang mendukung perubahan tersebut, menimbang bagaimana kesehatan mental di lingkungan sekolah juga menjadi salah satu isu yang menjadi perhatian pelaku pendidikan termasuk pekerja sosial di sekolah. Kata kunci: Pendidikan, kurikulum, kompetensi kebahagiaan, sikap spiritual, sikap sosial.
Analisis Keusangan dan Paro Hidup Literatur pada Jurnal Intizar Tahun 2013-2020
Authors: Marcelis Elvira , Herlina Herlina , Mulyadi Mulyadi
Published: July 2023

This study examines the Intizar Journal using Bibliometric studies, namely Literature Obsolescence and Literature Half Life. Bibliometric study of this journal is important because it is to find out the development of Contemporary Thought and Islamic Studies and Muslims. The purpose of this study was to determine the level of obsolescence of the literature cited in each scientific article published in the Intizar Journal in 2013-2020, and to determine the level of up-to-date information contained in the Intizar journal in terms of the half-life size of the document literature cited in 2013 -2020. This research is a type of descriptive research with a quantitative approach. Sampling using a total sampling technique or the entire population being studied is used as a sample, the sample in this study is all citations in the Intizar Journal 2013-2020. There are 140 articles with a total of 2305 citations. The results obtained from the calculations that have been carried out show that the highest level of literature obsolescence in the Intizar Journal in 2013-2020 is in volume 22 number 2 in 2016 which is 49.3%, while the lowest level of literature obsolescence is in the Journal. Intizar in 2013-2020 is contained in volume 19 number 2 in 2013 which is 15.7%. The highest half-life of the Intizar Journal Literature occurred in volume 21 number 2 in 2015 which was 24.02 years, while the lowest half-life occurred in volume 25 number 1 in 2019, which was 7.4 years, based on the calculation of the Literature Half-Life in the Intizar Journal. 2013-2020 is 12.11 years.
Social Inclusion-Based Community Learning Program at Dinas Kearsipan dan Perpustakaan (Diarpus) of Sukabumi District
Authors: Sastrawijaya Muhammad Ilyasa , Rianti Fahma
Published: July 2023

Social inclusion-based library transformation is an approach to library services committed to improving the library user community’s quality of life and welfare. Since 2014, Dinas Kearsipan dan Perpustakaan of Sukabumi district (Diarpus of Sukabumi district) has started implementing community learning programs. This study aims to identify the impact felt by the community related to welfare after participating in various social inclusion-based community learning programs implemented by the Diarpus of  Sukabumi district. This study uses a qualitative method with a phenomenological approach. Informants in this study were librarians, participants, and teachers of community learning programs. This research reveals that the community learning program implemented by Diarpus of Sukabumi district has helped the community develop its potential. It can be seen from several results; able to do business online through the Bukalapak application, produce Herbal Care Library as an herbal product, increase foreign language skills in English and Japanese, and increase public insight through writing classes in the library. The community also uses the library as a learning center and becomes more familiar with the library, and makes the library a vehicle for lifelong learning. Community learning programs need to reach out to the people of Sukabumi district more broadly, add a variety of activities, collaborate with more parties, and involve the community in program development.Social Inclusion-Based Community Learning Program at Dinas Kearsipan dan Perpustakaan (Diarpus) of Sukabumi
Literature Mapping about Walisongo in UIN Walisongo Library and its Use by Users
Authors: Miswan Miswan , Ulumi Bahrul , Akyas Gibran
Published: July 2023

This study examines the development and mapping of printed literatures on “Walisongo”. The study aims to reveal the strength of the collection concerning Walisongo among other collections in the UIN Walisongo library. The results showed that the query "Walisongo" illustrates that the collection of walisongo stored in the library is only 0.091 % of the total number of existing collections. The mapping based on the conspectus shows that 14 titles (48.28 %) of the collection above are at the comprehensive level; 6 titles (20.69%) are included in the research level category; 3 titles (10.34 %) are included in the instructional support level; 3 titles (10.34 %) are categorized as basic information level; 2 titles (6.90%) are at minimum level; and only 1 title (3.45%) is in the out of scope category. The mapping based on subject analysis shows that the books about Walisongo mostly study the da'wah of Walisongo, which shows 34.48%. The rest examines the subject of tarekat, the history of Islam in Indonesia, biographies of Islamic figures, Sufism, mythology, fiqh, sects, and Javanese history. Furthermore, mapping based on loan data from circulation services shows that all books about Walisongo have been borrowed by users.
Class Struggle in Maze Runner: The Death Cure Film
Authors: Ariefka Leandra Nur , Sa'diyah Sholikatus
Published: July 2023

This research analyzes how class struggle happened in the film: Maze Runner: The Death Cure. This study uses the qualitative method, which aims to understand the phenomenon experienced by the subject of the research, such as behavior, perception, and action. The author collects data for research taken from screenshots of several scenes related to analysis and the film's dialogue. The utilized theories in this research are Marxism, and the writer explained in detail the class social, both the bourgeoisie and proletarian, that can cause the conflict in the film based on Marxism Theory. The result of this research shows how class struggle that happened in the film with the problem of social class in this film that is an exploitation of the upper classes (bourgeoisie), namely the organization named WICKED, by the lower classes (proletariat), namely the youth and society who never get justice. Therefore, there was a rebellion movement from young people and the community (proletariat) to fight for their social status.
Body Positivity in The Main Female Character in Sierra Burgess is A Loser (2018) Film
Authors: Afantia Rifa , Supardi Moh
Published: July 2023

This research aims to explore the characterization of Sierra as the main female character reflecting body positivity presented in the Sierra Burgess Is a Loser (2018) film directed by Ian Samuels. This research uses the descriptive qualitative method supported by the character and characterization theory by Joseph M. Boggs and Dennis W. Petrie and representation theory by Stuart Hall. This research also uses the concept of body positivity by Tracy and Wood Barcalow to support the analysis. In the Sierra Burgess Is a Loser film, Sierra represents intelligence, independence, and confidence as a teenage girl who reflects body positivity. She struggles to achieve her freedom as a plus body size woman. Becasue of her plus body size, Sierra experiences injustice and bullying as a fat girl in her school. Sierra reflects body positivity as she fights to gain her confidence and face her fear through the struggles of being a fat girl. Moreover, it shows that Sierra Burgess Is a Loser (2018) film tries to support the body positivity movement as the film portrays Sierra as an intelligent woman who breaks the stereotype of unrealistic body image and manages to embrace other women to have a body positivity image.
The Accuracy and Quality Translation of Google Translate toward Harf Al Ma'ānī in Arabic
Authors: Zainab Siti , Saehudin Akhmad , Al-Ummat Robby Malik , Noer Shuhaila Diva
Published: July 2023

Technological developments have a major impact on human life. The existence of machine translation is the result of technological advances to make it easier for humans to translate one language into another. This research focuses on the accuracy of google translate in translating burf ma'ani in Arabic. The corpus of data that is the object of this research is a number of texts such as in the book Dalilun fi Al-Tarjamah by DR. H. Rofi'i. The method used in this study is a qualitative method (qualitative method) by comparing the google translate translation with the translation according to Arabic rules. Data collected through library research (brary research). The results showed that in terms of accuracy of vocabulary and terms, google translate has a fairly good translation quality, both in terms of clarity and fairness of meaning. However, google translate is not able to convey ideas from the source language (SL) Arabic into the target language (TL). From these data it can be seen that google translate should not be used as a basis for translating Arabic texts into Indonesian, especially in translating the verses of the harfu Ma'aniy. A novice translator should choose a dictionary instead of using google translate for business and improve translation skills.
Hybridity and Cultural Identity in Warga’s Novel Other Words for Home
Authors: Nurhusna Siti Deviana Rahma
Published: July 2023

This research aims to show how Jude, as a Syrian character, interprets the notion of a home in Jasmine Warga’s Other Words for Home (2019) and how it explicitly opposes American Exceptionalism. The writer chooses the study of home in the novel to enhance the analysis of Other Words for Home, which generally focuses on the novel's Syrian character. This research uses postcolonial diasporic criticism, especially hybridity and cultural identity, as the theoretical framework for evaluating Warga’s Other Words for Home. The home is not only a place of immigrants for the diaspora but is related geographically and psychologically. For diasporas, the home has become a wounded concept that forces them to deal with scars, blisters and sores, and psychic traumas while on migration. Warga tells the story of Syrian immigrants who moved to America due to the political turmoil in Syria. She portrays racism, alienation, and prejudice as a black spectacle in which Jude becomes a victim. Jude is depicted as a teenager struggling to acculturate herself in the in-between spaces between homeland and host land. It creates a hybrid identity as Jude's identity is manifested by her use of mixed dialects in daily conversation, behaviour, and triumph. This study demonstrates that identity is a fluid concept. Thus, through this hybrid identity, Jude challenges the dominance of American Exceptionalism in the US and the world regarding Arab Muslims.
Retaining the Readability of Cultural Words Translation: The Case of Indonesian Subtitles in Breadwinner Film
Authors: Suriadi M. Agus , Anwar Alma Nadia
Published: July 2023

This study is a translation quality assessment of cultural words translation in the Breadwinner film. It is done firstly by categorizing the cultural words and translation procedures based on Peter Newmark’s theory. Then, to find out the readability level of cultural word translation, the study uses Nababan’s theory. The data is collected by watching the film, underlining the cultural words, and classifying and tabulating the selected data in the source and target text. The film has 12 data of cultural words, which are classified into ecology, material, social, and social-political organization cultural categories. It is also found that transference, naturalization, couplet, and synonymy are categorized based on the theory. In addition, it is found that 6 data are readable, 4 are less readable, and 2 are not readable. Therefore, retaining the readability and meaning of the original text is still needed to be increased to bridge to overcome the lack of meaning in the target language as great different cultures are found, and the readability of cultural words’ translation shows that the original word plays a crucial role.
Deconstructing Hijabs in Sabyn Javeri’s Hijabistan
Authors: Parween Shenaz
Published: July 2023

In the contemporary world of racism and Islamophobia, the Hijab is just the tip of an iceberg, while its meanings are far deeper and more complicated. These heterogeneous meanings of the Hijab and its wearer in the outside world are well handled by Sabyn Javeri, a Pakistani award-winning author and Professor, in her short-story collection called Hijabistan. Comprising 16 politically provocative short stories based on the metaphorical interpretation of the veil in the lives of Muslim women, Javeri challenges the single one-dimensional narratives of hijabi identity by presenting the real usage of Hijab in the right and wrong way within the current society. In each story, the Hijab, takes on a new role; for some it becomes a weapon to satisfy one’s urges, while for others it functions as a source of patriarchal oppression or a symbol of segregation from mainstream society. There are also a few who wear the Hijab as a badge of honor, while others do not see it as a barrier within their active sexual life. The paper focuses on these multi-dimensional meanings of the Hijab while critically analyzing how the characters achieved their goals while wearing the veil and how some are seeking their identity.
Virtual Mediation of the Holy Spirit
Authors: Cartledge Mark J
Published: July 2023

This article explores the prospect for an academic account of digital Pentecostalism given the propensity that Pentecostals have towards the use of modern technology. It uses a recent Roman Catholic discussion of “virtual communion” as a point of departure and aims to transpose the discussion into a Pentecostal key. Using the concept of the mediation of the Holy Spirit as a bridge between the two traditions it considers the transposition of virtual communion, virtual logic and remediation, as well as the internet as an ancillary or alternative space. The intention of the article is not to offer a definitive account but to develop a conversation around digitally mediated Pentecostalism. This is a conversation that has already started but, in light of a greater dependency on internet communication due to Covid-19, invites more sustained attention.
Unbound Bible
Authors: Alves Leonardo
Published: July 2023

The triad of Spirit, Word, and Community is a model that often represents Pentecostal hermeneutics. Focusing on the Word—a particularly elusive term for the Pentecostal hermeneutics—this study suggests some insights from an ethnography among Latin Pentecostal networks in the Nordic countries. Despite holding the Word with high regard, it exists as an “unbound Bible.” The Word is multiform: the Bible as an artifact, the relational divine agent, and a message. Many interpretative practices shape and limit the content of this unbound Bible. These interpretative practices include an analogical narrative reading that associates migration stories with biblical content, transnational and multilingual contexts, and a fragmentary and recursive reconfiguring of biblical texts for proper occasions. This study contributes to understanding migrant hermeneutics and discusses the Pentecostal triadic model of Spirit, Word, and Community.
Births in the United States, 2022
Authors: Martin Joyce , Hamilton Brady , Osterman Michelle
Published: July 2023

This report presents highlights from 2022 final birth data on key demographic, healthcare utilization, and infant health indicators.
La conservación de la naturaleza en las políticas de ordenamiento territorial: estado del arte internacional y situación latinoamericana
Authors: Degele Pamela E.
Published: July 2023

Los cambios en los usos del suelo aparecen como uno de los impulsores directos del cambio ambiental global. En consecuencia, las recomendaciones internacionales indican la necesidad de integrar las áreas naturales protegidas en las políticas de ordenamiento territorial para favorecer la conservación de la naturaleza, sus valores culturales y servicios ecosistémicos en el largo plazo. Esto es posible al entender que la conservación de la naturaleza es una temática compleja que atraviesa y es atravesada por numerosos asuntos territoriales como la economía, la política y la cultura. Sin embargo, la articulación entre las áreas protegidas y las políticas de ordenamiento territorial constituye aún más un desafío generalizado.  En este artículo se expone en qué medida y de qué manera la comunidad científica internacional ha respondido a la necesidad de conocimientos sobre esta temática haciendo foco, particularmente, en el enfoque social de estos procesos. Esta perspectiva es relevante en tanto permite identificar valores, comportamientos sociales y factores políticos para una coordinación eficaz que favorezca la mitigación de la crisis socio-ecológica de “abajo hacia arriba”. Para ello, se presentan los resultados de una revisión sistemática de literatura internacional y, particularmente, latinoamericana, indexada en la base de datos Scopus de los últimos 20 años, complementada con una búsqueda en Scielo y otra bibliografía académica disponible sobre el tema en la región. Se identificaron tres enfoques principales en la literatura, con prevalencia de una visión técnica de la articulación de las áreas protegidas en el ordenamiento territorial, orientada a la medición y predicción de impactos y áreas prioritarias, antes que de análisis de variables políticas y sociales. Se propone una agenda de investigación.
Cultivos genéticamente modificados en los países del Río de la Plata y derechos de propiedad intelectual
Authors: Terradas-Cobas Liliana , Gutiérrez Ofelia , Céspedes-Payret Carlos
Published: July 2023

La región de la Cuenca del Rio de la Plata, es actualmente la principal proveedora mundial de granos genéticamente modificados (GM). Así, ha configurado una matriz extractivista exportadora que revitalizó la primarización de la economía y creó nuevas formas de dependencia. Por su parte, los países centrales promueven su economía basada en el conocimiento y fortalecen los instrumentos legales que garantizan la propiedad de los derechos intelectuales. La hipótesis subyacente es que la complementación de dichos modelos es uno de los principales motores indirectos del cambio global. Tomando como base la literatura especializada y el reprocesamiento de información extraída de bases de datos de instituciones internacionales y/o regionales, el artículo tiene como objetivo principal examinar, en perspectiva comparada, aspectos del modelo de desarrollo de los países rioplatenses (Argentina, Brasil Paraguay y Uruguay) y de sus principales socios comerciales extra regionales (China, la Unión Europea y Japón), a la luz del concepto de extractivismo y en dialogo con el enfoque teórico del capitalismo cognitivo. Concluimos que, en la Cuenca del Río de la Plata, se ha configurado un modelo productivo extractivo sumamente funcional a las necesidades de los países desarrollados. Estos han consolidado un capitalismo que necesita no sólo materias primas importadas para satisfacer su demanda interna sino también la creación, distribución y utilización de bienes inmateriales, como los derechos de propiedad intelectual, los cuales, al ser incorporados a l os insumos utilizados para la producción de materia prima, logran asegurar la acumulación del capital. En consecuencia, los impactos de los impulsores indirectos difieren según las regiones y, de esta forma, se configuran distintos modelos de desarrollo que, al complementarse, alimentan la dinámica del actual metabolismo social.
Lógicas y dinámicas neoliberales: subjetividad y empresario de sí
Authors: González Pérez Jaime Andrés
Published: July 2023

El presente artículo es producto de un ejercicio de revisión bibliográfica realizado en el marco del primer Seminario de Investigación del doctorado en Formación en Diversidad, en el cual se abordaron, en su momento, conceptos claves como: Neoliberalismo, subjetividad y empresario de sí. Su objetivo es relacionar y problematizar los fundamentos de la economía neoliberal del siglo XX; el empresario de sí como mecanismo o dispositivo biopolítico de poder y rendimiento; y las nuevas prácticas de subjetivización o de constitución del sujeto contemporáneo basadas en la generación del deseo, la deuda y la culpa. Esto, bajo una premisa en común: el neoliberalismo requiere de la fabricación de cierto tipo de subjetividades productivas, fundamentadas en el mito de la liberación y la felicidad del sujeto, para su funcionamiento y reproducción. El artículo se divide en cuatro apartados: en primer lugar, la naturaleza del liberalismo del siglo XX, donde se exponen algunas características y transformaciones que ha sufrido éste desde la Guerra Fría y Mayo del 68. Segundo, el empresario de sí, un breve estudio sobre la forma biopolítica de construcción de las subjetividades productivas, de rendimiento, de culpa y de sometimiento al capital características del mundo contemporáneo. Tercero, el sujeto neoliberal, su psique, emocionalidad y subjetividad; donde se valora a detalle las implicaciones y consecuencias de estas prácticas biopolíticas en el sujeto. Finalmente, en el cuarto apartado se lleva a cabo una corta reflexión acerca de la relación existente entre dichos conceptos y los problemas que éstos plantean a nivel epistemológico en el mundo contemporáneo. El artículo presenta una manera distinta de entender las lógicas y dinámicas neoliberales, las prácticas biopolíticas y el impacto a nivel de la subjetividad del sujeto. Concretamente, permite una reflexión acerca de los principios del liberalismo, sus límites y contradicciones.
STATISTICAL CONVERGENCE IN A BICOMPLEX VALUED METRIC SPACE
Authors: Bera Subhajit , Tripathy Binod Chandra
Published: July 2023

In this paper, we study some basic properties of bicomplex numbers. We introduce two different types of partial order relations on bicomplex numbers, discuss bicomplex valued metric spaces with respect to two different partial orders, and compare them. We also define a hyperbolic valued metric space, the density of natural numbers, the statistical convergence, and the statistical Cauchy property of a sequence of bicomplex numbers and investigate some properties  in a bicomplex metric space and prove that a bicomplex metric space is complete if and only if two complex metric spaces are complete.
SUM SIGNED GRAPHS – II
Authors: Ranjith Athira P. , Kureethara Joseph Varghese
Published: July 2023

In this paper, the study of sum signed graphs is continued. The balancing and switching nature of the graphs are analyzed. The concept of  \(rna\) number is revisited and an important relation between the number and its complement is established.
LATTICE UNIVERSALITY OF LOCALLY FINITE \(p\)-GROUPS
Authors: Repnitskiǐ Vladimir B.
Published: July 2023

For an arbitrary prime \(p\), we prove that every algebraic lattice is isomorphic to a complete sublattice in the subgroup lattice of a suitable locally finite \(p\)-group. In particular, every lattice is embeddable in the subgroup lattice of a locally finite \(p\)-group.
FIXED RATIO POLYNOMIAL TIME APPROXIMATION ALGORITHM FOR THE PRIZE-COLLECTING ASYMMETRIC TRAVELING SALESMAN PROBLEM
Authors: Rizhenko Ksenia , Neznakhina Katherine , Khachay Michael
Published: July 2023

We develop the first fixed-ratio approximation algorithm for the well-known Prize-Collecting Asymmetric Traveling Salesman Problem,  which has numerous valuable applications in operations research. An instance of this problem is given by a complete node- and edge-weighted digraph \(G\). Each node of the graph \(G\) can either be visited by the resulting route or skipped, for some penalty, while the arcs of \(G\)  are weighted by non-negative transportation costs that fulfill the triangle inequality constraint. The goal is to find a closed walk that minimizes the total transportation costs augmented by the accumulated penalties. We show that an arbitrary \(\alpha\)-approximation algorithm for the Asymmetric Traveling Salesman Problem induces an \((\alpha+1)\)-approximation for the problem in question. In particular, using the recent \((22+\varepsilon)\)-approximation algorithm of V. Traub and J. Vygen that improves the seminal result of  O. Svensson, J. Tarnavski, and L. Végh,  we obtain \((23+\varepsilon)\)-approximate solutions for the problem.
Advances in the Management of Neuroblastoma
Authors: Qadir Muhammad Imran , Ahmed Bilal , Noreen Sumaira
Published: July 2023

Neuroblastoma is a malignant tumor of neuroblasts, immature nerve cells found in several areas of the body. It usually affects children under age of 5. As usual, the tumor has ability to grow rapidly and to expand vastly which ultimately leads to death. Mostly, management decisions can be drawn by the prediction of the stage of the disease as well as age at the time of its diagnosis. There are four main stages of neuroblastoma, and treatment is according to the low and high risk of the disease. Several cytotoxic agents along with other therapies (antibody therapy, gene therapy, and even immunological therapies, antiangiogenic therapy, etc.) are used. Immunotherapy also has an important treatment option used nowadays for neuroblastoma. The discovery of major neuroblastoma-predisposition gene anaplastic lymphoma kinase cause somatic transformation or gene strengthening in diagnosed neuroblastoma. Promising new antiangiogenic strategies have also been introduced for the treatment of neuroblastoma with multiple mylomas. To manage numerous myelomas and cancers, including neuroblastoma, bone marrow transplantation and peripheral blood stem cell transplantation may be used.
Efficacy of Ozonated Olive Oil Gel in the Management of Peri-Implant Mucositis
Authors: Choudhary Apurva , Rajasekar Arvina
Published: July 2023

Peri-implant mucosistis is similar to gingivitis, the former affects the mucosa around implants without bone loss. The aim of this study was to determine the effectiveness of ozonated olive oil gel in the management of peri-implant mucositis. A randomized controlled clinical trial was conducted among 50 patients with peri-implant mucositis within the age group of 25-50 years. They were randomly divided into two groups with 25 participants in each group based on the intervention [Group A (Ozonated olive oil gel), Group B (Chlorhexidine gel)]. Silness and Loe plaque index (PI) and Loe and Silness gingival index (GI) were recorded at baseline and after 4 weeks. Paired t-test and independent t-test was used to test the significance. Within the groups, there was a statistically significant reduction in PI and GI from baseline (P < 0.05). However, the difference in PI and GI between both the groups was statistically insignificant (P > 0.05). Ozonated olive oil gel was equally effective to chlorhexidine gel in the management of peri-implant mucositis.
Deep Eutectic Solvent Coupled with High Performance Liquid Chromatography for Extraction of Bisphenols and Phthalates from Selected Freshwater Source in Selangor, Malaysia
Authors: Balaraman Jananee , Md Saleh Noorashikin , Mat Salleh Muhammad Zulhaziman , Yusoff Farhanini , Asman Saliza
Published: July 2023

Bisphenol A (BPA) and phthalates (PAEs) are endocrine disrupting chemicals that are abundantly found in the environment. These chemicals leach from polycarbonate plastics and epoxy resins into the environment when exposed to heat. Human exposure to these chemicals causes various health issues; hence, the detection of BPA and PAEs has become more sensitive, and thus it is the most important environmental issue to be reduced due to consequences on human health. This research aimed to determine the optimum parameter of extraction process for BPA and PAEs from water samples by using deep eutectic solvent (DES) coupled with high performance liquid chromatography- ultraviolet spectroscopy (HPLC-UV). Water samples for BPA and PAEs extraction were from various rivers and lakes in Selangor. The solvent used in the DES was a mixture of decanoic acid and tetrabutylammonium iodide. The extraction parameters that have been studied are molar ratio i.e., 1:2, 1:3 and 1:4, extraction time i.e., 10, 15 and 20 min, extraction temperature i.e., 50, 60 and 70 ºC and solvent volume i.e., 3, 6 and 9 mL. The optimum molar ratio of solvent and extraction time were 1:2 and 20 min, respectively. The best extraction temperature and volume of solvent with the highest recovery rate were 70 ºC and 3 mL. Sungai Kuang shows the highest bisphenol-A concentration of 23.9613 µg/L while Sungai Nada has the highest benzyl-butyl phthalates concentration of 73.6834 µg/L. Sungai Damansara shows the highest dibutyl phthalates concentration of 7.3163 µg/L. In conclusion, data obtained in this research will contribute a new knowledge in the Sustainable Development Goals 6, which is clean water and sanitation because the world is progressing to increase access to clean drinking water and sanitation. There are also some other endocrine disrupting chemicals (EDC) such as disinfection byproducts and pesticides which is more suitable to be extracted from water samples using solid phase microextraction due to low contamination in water. It is very important to research, detect and extract the bisphenol and phthalates from water sources as these pollutants might cause health issues and environmental pollutions which cannot be resolved in future due to its smaller size and its existence in large quantity.
Diorganotin(IV) N-methyl-N-phenethyldithiocarbamate Compounds Induce Cytotoxicity via Apoptosis in K562 Human Erythroleukaemia Cells
Authors: Syed Annuar Sharifah Nadhira , Kamaludin Nurul Farahana , Awang Normah , Chan Kok Meng , Uttraphan Pim Norraphat
Published: July 2023

Imatinib mesylate (IM), a leading treatment for chronic myeloid leukaemia (CML), has sparked worries about the possibility of CML patients developing a resistance to it. As a result, researchers are becoming more interested in organotin(IV) compounds due to their strong potential to be developed as anticancer agents and employed as an option to address the issues regarding IM-resistance therapy. Generally, this study is to determine the cytotoxicity induced by diorganotin(IV) dithiocarbamate compounds in K562 human erythroleukaemia cells. The two novel diorganotin(IV) compounds namely diphenyltin(IV) N-methyl-N-phenethyldithiocarbamate (C1) and dibutyltin(IV) N-methyl-N-phenethyldithiocarbamate (C2) were assessed their cytotoxicity via MTT [3-(4-5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay and mode of cell death via Annexin V-FITC/PI assay with the duration treatment of 24 h. Both compounds displayed strong cytotoxicity in K562 cells. At concentration of 4.2 µM for C1 and 1.6 µM for C2, both compounds were able to induce 49.70% and 46.83% apoptotic events, respectively. The changes in cells' morphological can also be seen 24 h after being exposed to the compounds at their respective IC50 doses. The findings demonstrated that the morphology of the cells was similar to apoptotic features, including cell shrinkage and the production of apoptotic bodies, meanwhile, the low levels of necrotic cells (<1%) also can be seen via cell lysis. In conclusion, both compounds possess the potential as antileukaemia drugs nevertheless, further studies on their action mechanism are required to ratify their qualities and suitability in the research of anticancer drugs development.
Identifying Outlier Subjects in Bioavailability Trials using Generalized Studentized Residuals
Authors: Lim F.P. , Wong L.L. , Yap H.K. , Yow K.S.
Published: July 2023

This paper discusses several outlier detection methods for bioavailability trials, particularly based on residuals. By considering a simplified model of standard crossover model, which is commonly used in bioavailability trials, we propose an outlier detection procedure based on the generalized studentized residuals (SR3) and compare its ability of detecting the possible outlying subjects with two existing procedures, which are carried out based on the classical studentized residual (SR1) and studentized residual using median absolute deviation (SR2). The performances of these procedures in detecting outlying subject are presented via an extensive simulation study. The results show that the proposed procedure SR3 performs more powerful than that using SR1, and as well as the procedure using SR2 for outlier detection. As an illustration, these procedures are implemented on a real dataset from bioavailability study, namely, the area under the curve (AUC) dataset for two erythromycin formulations.
Persistent postural-perceptual dizziness as a regulatory dysfunction of the balance system
Authors: Mirzaeva Liudmila M. , Voronov Victor A. , Demidenko Diana Yu. , Savinova Anna K. , Griva Arina I.
Published: July 2023

The problem of chronic functional dizziness is highly relevant nowadays. In case of a great number of patients suffering from persistent postural-perceptual dizziness, lack of a unified understanding of the pathogenesis, diagnostic mistakes, and, as a result, improper treatment lead to a deterioration in the quality of life and disability. The purpose of the review is to analyse and highlight the persistent postural-perceptual dizziness problem, to explore the currently existing pathogenetic concepts, methods of diagnosis and treatment of this group of patients. Domestic and foreign scientific papers have been analysed using the largest world citation databases according to the following keywords: psychogenic dizziness, chronic subjective dizziness, vestibular rehabilitation, stabilometry, persistent postural-perceptual dizziness, postural phobic instability, selective serotonin reuptake inhibitors, cognitive behavioral therapy. The data of 78 scientific works of the research subject are the basis of the review. The article presents a brief historical background, contemporary conceptions of pathogenesis, symptoms and clinical manifestations of persistent postural-perceptual dizziness. The particular attention is given to the diagnostic methods and treatment principles. Relevant questionnaires and diagnostic scales as well as the Barany Society criteria are also considered. A multidisciplinary approach to treatment which allows to achieve a lasting positive effect is described. Segregation of persistent postural-perceptual dizziness into a separate nosological item, understanding of its pathogenesis, an integrated approach to diagnosis with assessment of structural, functional and mental disturbances, just like complex therapeutic strategies make а fully recovery possible.
Differential diagnosis of thrombocytosis: a case study
Authors: Budai Aleg P. , Ermolov Sergei Yu. , Dobritca Valerii P. , Ilyashevich Inna G. , Apresyan Anna G.
Published: July 2023

The article presents a clinical case of an unclassifiable myeloproliferative neoplasm in a 65-year old patient. Platelet count is not a criteria for differential diagnosis of reactive and tumor processes. A typical course of the disease is associated with the persistence of symptoms of microcirculation disorder against the background of previous asymptomic thrombocytosis for several years. The diagnosis of an unclassifiable myeloproliferative neoplasm is established by a combination of clinical, laboratory, instrumental, molecular genetic and morphological methods of research.
The Homestead Emergence
Authors:   , Mariotti Mia  Isabella , Zitcer Andrew
Published: July 2023

The emergence of modern homesteading is a strategy practiced by people who seek healthier, more sustainable options for their families, both physically and spiritually. The practice dates to the Homestead Act of 1862, however, the practices of tending to and stewarding the land closely resemble those of Indigenous lifestyles dating back much earlier than 1862. Historic literature provides a basis for understanding the implications of the Homestead Act of 1862 and Indigenous teachings, however limited literature exists on the modern-day practice, how it is a strategy for ecological, social, and spiritual restoration, and how it mirrors Indigenous precepts. This research paper includes qualitative data gathered through in-depth interviews with homesteaders and small-scale farmers, ranging from urban to rural practitioners. Although homesteading may be closely tied to the goal of self-sufficiency, my research suggests that community-sufficiency is more foundational and sustainable for the practice. The homesteaders with whom I spoke all share in the sentiments of providing healthier options for their families while fulfilling a longing to live a life that aligns with their values. My findings reveal the challenges and limitations of this study, including the limited demographic that practices this way of life.
Ansiedad en la adultez: Tratamiento Estratégico Cognitivo Conductual en una paciente de 24 años
Authors: Cavero Reap Rocio del Pilar , Cornejo del Carpio Manuel Francisco
Published: July 2023

El presente estudio tuvo como objetivo reducir las conductas ansiosas, promoviendo un repertorio de conductas funcionales; además, establecer estrategias de afrontamiento para disminuir los síntomas de ansiedad, mediante el uso de técnicas de reestructuración cognitiva y relajación. De acuerdo a su metodología fue experimental, de tipo caso único. Asimismo, los instrumentos utilizados fueron: Entrevista y observación, el Inventario Clínico Multiaxial De Millon III (Millon III), el Inventario De Ansiedad Estado–Rasgo (STAI) y la Escala De Autovaloración De La Ansiedad De Zung (Test De Zung - EAA). Del mismo modo, se realizó un diagnóstico de tipo multiaxial, análisis topográfico y funcional. Por último, se elaboró un plan de tratamiento bajo un enfoque Cognitivo-Conductual y se utilizaron técnicas como tales como programación de actividades lúdicas y de ocio, autorregistro de conductas, técnicas de relajación y respiración, reestructuración cognitiva y psicoeducación. Finalmente, se identificó una evolución favorable de la paciente, mediante la evaluación integral, el diagnóstico y la aplicación de las técnicas psicológicas.
Hypospadias with cryptorchidism presented as ambiguous genitalia and its management with surgery
Authors: Nooruzzaman M. , Hossain A. K. M. Zahid , Shabuj M. Kamrul Hassan , Mondal Susankar Kumar , Mahammad Noor , Saiful Islam K. M. , Munmun Umme Habiba Dilshad , Atiquzzaman Tarafder Mohammad
Published: July 2023

Background: The incidence of hypospadias with cryptorchidism is about 6-31.6%. Current management recommendations are that undescended testis beyond three months needs surgery between 6-12 months of age. Proximal hypospadias and cryptorchidism overlap with disorders of sex development and endocrine problem. The aim of this study was to assess the outcome of surgical management of hypospadias with cryptorchidism, at selected centers in Dhaka, Bangladesh.
Methods: This prospective study was conducted in the Department of Pediatric Surgery of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh during the period from January,2018 to January, 2022. In this study, we included 70 diagnosed cases of hypospadias with cryptorchidism presented as ambiguous genitalia who underwent surgery.
Results: Mean age at surgery was 4.6±1.4 years and majority (91.4%) were male. Associated renal anomalies were absent in 81.4% cases, symptomatic renal anomalies were present in 11% cases, severe chordee was 37%. Abnormal hemiscrotum was 10% and normal hemiscrotum was 1.4%. Hernia with cryptorchidism was present in 30 % cases. Testosterone was normal in 94.3% patients, estrogen and progesterone was elevated in 5.7% patients. After operation, male was 94.3% and female was 2.9%, chordee condition was corrected in 81.4% and urine passed through tip of penis in 84.3% patients.
Conclusions: We found that surgery is simple, safe, and effective in the treatment of patients with hypospadias and cryptorchidism with satisfactory functional results, normal physical health status, improved quality of life, satisfying psychological support and probably less pain.