bluuebunny/crossref_metadata_2025 huggingface dataset:
Changing Facets of Hyderabadi Tehzeeb: Are we missing anything?
Authors: Pandey Vinita
Published: February 2016

In its historic evolution and development, the Hyderabad city has experienced many changes since its foundation as the capital of the medieval Kingdom of Golconda in the 16th century to its present status as the metropolis of a modern state. Each historic phase of development has significantly influenced its physical, social, economic and cultural growth. Hyderabad, under the influence of Deccan, Persian and indigenous culture, synthesised and evolved its very own Hyderabadi Tehzeeb. It truly represented the assimilation (yet uniqueness) of diverse cultures which inhabited Hyderabad. More than four hundred years later, HITEC city Hyderabad today presents a different picture. Whether it is its structural and spatial expansion, infrastructural development or its socio-cultural ethos, contemporary Hyderabad has evolved phenomenally and for many natives beyond recognition. Using ethnographic approach and secondary data, the paper introspects whether the City of Pearls has retained its unblotted tolerance and Hyderabadi Tehzeeb or has given up to the challenges of modern and globalizing times. Culturally, what is it that the natives of â€˜Bhagyanagarâ€™ irrespective of their caste, creed, gender, region and religion miss in modern Hyderabad.
Politics of Locating Muslim Women in Islamic Discursive Tradition in India
Authors: Sur Esita
Published: February 2016

In postcolonial India, narratives about Muslim women have revolved around tropes, such as tin talaq (divorce), purdah (veil), polygamy and Islam. These have always played a significant role to shape their homogenised identity: an existence of oppression and subordination. However, the paper will try to argue that the marginalisation of Muslim women is not only structural but also discursive (popular as well as religious), which produce them as â€˜victimsâ€™ and â€˜voiceless othersâ€™. The paper will also try to argue that Muslim women have already been discursively produced as incapable of progressive thinking, and waging struggle against their subordination. Therefore, the paper shall make an attempt to examine the impact of popular as well as Islamic discourses in shaping the identity of Muslim women in India, and locate those alternative spaces, where Muslim women can challenge their homogenised existence as a category as well as dominant discourses on their victimhood.
Corporate Social Responsibility (CSR) in India: A Review
Authors: Jaysawal Neelmani , Saha Sudeshna
Published: February 2016

Corporate Social Responsibility (CSR) is a concept, which states that Private Corporation or public organization has a responsibility to society. It minimizes the cost as well as risks thereby, increasing the brand value and reputation of the company. According to Bowen, â€œCSR refers to the obligations of businessmen to pursue those policies to make those decisions or to follow those lines of relations which are desirable in terms of the objectives and values of our society.â€ The CSR activities need to be in tune with effective strategic policies so that the aim of sustainable environmental, social and economic progress may be achieved.

Methodology: This paper is based on qualitative research design consisting of review of literature through secondary sources of data collection. The data has been examined through content analysis process from various books, newspaper articles and journals.

This paper seeks to explain various initiatives taken in the field of CSR along with some key challenges.
Surgical and Functional Outcomes After Limb-Preservation Surgery for Tumor in Pediatric Patients
Authors: Groundland John S. , Ambler Steven B. , Houskamp LT Daniel J. , Orriola John J. , Binitie Odion T. , Letson G. Douglas
Published: February 2016

Background:

Limb-salvage surgery and segmental reconstruction for the treatment of lower extremity osseous tumors in the pediatric population have been described in the literature, but there is little consensus regarding the optimal surgical treatment for this patient population.

Methods:

A systematic review of the literature was performed to identify studies focusing on limb-salvage procedures in pediatric patients who were managed with one of three reconstructions with use of a metallic endoprosthesis, allograft, or allograft-prosthesis composite. Data were segregated according to the excised and reconstructed anatomical location (proximal part of the femur, total femur, distal part of the femur, proximal part of the tibia) and were collated to assess modes of failure and functional outcomes of each reconstruction type for each anatomic location.

Results:

Sixty articles met the inclusion criteria; all were Level-IV evidence, primarily consisting of small, retrospective case series. Infection was a primary mode of failure across all reconstruction types and locations, whereas allograft reconstructions were susceptible to structural failure as well. The rate of failure in the pediatric population correlated well with previously published results for adults. The incidence of subsequent amputation was lower in the pediatric population (5.2%) than has been reported in adults (9.5%) (p = 0.013). Meaningful growth of expandable metallic endoprostheses was reported in the literature, with an overall rate of leg-length discrepancy of 13.4% being noted at the time of the latest follow-up. The Musculoskeletal Tumor Society (MSTS) questionnaire was the most consistently used outcome measure in the literature, with average scores ranging from 71.0% to 86.8%, depending on reconstruction type and anatomic location.

Conclusions:

The current state of the literature detailing the surgical and functional outcomes of segmental reconstruction for the treatment of pediatric bone tumors is limited to Level-IV evidence and is complicated by under-segregation of the data by age and anatomical location of the reconstruction. Despite these limitations, pediatric limb-salvage surgery demonstrates satisfactory initial surgical and functional outcomes.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Geochemical classification of groundwater using multivariate statistical analysis in Latvia
Authors: Retike Inga , Kalvans Andis , Popovs Konrads , Bikse Janis , Babre Alise , Delina Aija
Published: February 2016

Multivariate statistical methods – principal component analysis (PCA) and hierarchical cluster analysis (HCA) – are applied to identify geochemically distinct groundwater groups in the territory of Latvia. The main processes observed to be responsible for groundwater chemical composition are carbonate and gypsum dissolution, fresh and saltwater mixing and ion exchange. On the basis of major ion concentrations, eight clusters (C1–C8) are identified. C6 is interpreted as recharge water not in equilibrium with most sediment forming minerals. Water table aquifers affected by diffuse agricultural influences are found in C3. Groundwater in C4 reflects brine or seawater admixture and gypsum dissolution in C5. C7 and C2 belong to typical bicarbonate groundwater resulting from calcite and dolomite weathering. Extremely low Cl− and SO42− are observed in C8 and described as pre-industrial groundwater or a solely carbonate weathering result. Finally, C1 seems to be a poorly defined subgroup resulting from mixing between other groups. This research demonstrates the validity of applying multivariate statistical methods (PCA and HCA) on major ion chemistry to distribute characteristic trace elements in each cluster even when incomplete records of trace elements are present.
Seismic Ductility Reduction of Flexural-type Structures with Vertical Irregularities
Authors: Zhao Weifeng , Hu Xiaoquan , Long Zhilin
Published: February 2016

Seismic ductility reduction factors for flexural-type structures with vertical irregularities subjected to pulse-like and non-pulse-like ground motions are investigated in this paper. By establishing various multi-node flexural cantilever-column models, the ductility reduction factor of vertically irregular structures is studied by modifying the ductility reduction factor of irregular structures. The effects of various factors such as ductility level, irregular ratio and pulse-like earthquake excitation on modification coefficient are also explored. The analysis results reveal that: 1) the modification coefficient decreases with smaller irregularity ratio; 2) ductility reduction factors for vertically irregular structures are significantly smaller than those of regular structures; 3) ductility level exerts a certain influence on ductility reduction factor without an obvious trend; and 4) the modification coefficient under pulse-like excitation is smaller than those from non-pulse-like motions and the influence of pulse-like earthquake is coupled with irregularity ratio. This paper concludes with the statistical outcomes based on average of results and recommends modified factors for practice uses.
Shift to Fatty Substrate Utilization in Response to Sodium–Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes
Authors: Ferrannini Ele , Baldi Simona , Frascerra Silvia , Astiarraga Brenno , Heise Tim , Bizzotto Roberto , Mari Andrea , Pieber Thomas R. , Muscelli Elza
Published: February 2016

Pharmacologically induced glycosuria elicits adaptive responses in glucose homeostasis and hormone release. In type 2 diabetes (T2D), along with decrements in plasma glucose and insulin levels and increments in glucagon release, sodium–glucose cotransporter 2 (SGLT2) inhibitors induce stimulation of endogenous glucose production (EGP) and a suppression of tissue glucose disposal (TGD). We measured fasting and postmeal glucose fluxes in 25 subjects without diabetes using a double glucose tracer technique; in these subjects and in 66 previously reported patients with T2D, we also estimated lipolysis (from [2H5]glycerol turnover rate and circulating free fatty acids, glycerol, and triglycerides), lipid oxidation (LOx; by indirect calorimetry), and ketogenesis (from circulating β-hydroxybutyrate concentrations). In both groups, empagliflozin administration raised EGP, lowered TGD, and stimulated lipolysis, LOx, and ketogenesis. The pattern of glycosuria-induced changes was similar in subjects without diabetes and in those with T2D but quantitatively smaller in the former. With chronic (4 weeks) versus acute (first dose) drug administration, glucose flux responses were attenuated, whereas lipid responses were enhanced; in patients with T2D, fasting β-hydroxybutyrate levels rose from 246 ± 288 to 561 ± 596 µmol/L (P < 0.01). We conclude that by shunting substantial amounts of carbohydrate into urine, SGLT2-mediated glycosuria results in a progressive shift in fuel utilization toward fatty substrates. The associated hormonal milieu (lower insulin-to-glucagon ratio) favors glucose release and ketogenesis.
Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain
Authors: Scherer Thomas , Lindtner Claudia , O’Hare James , Hackl Martina , Zielinski Elizabeth , Freudenthaler Angelika , Baumgartner-Parzer Sabina , Tödter Klaus , Heeren Joerg , Krššák Martin , Scheja Ludger , Fürnsinn Clemens , Buettner Christoph
Published: February 2016

Hepatic steatosis is common in obesity and insulin resistance and results from a net retention of lipids in the liver. A key mechanism to prevent steatosis is to increase secretion of triglycerides (TG) packaged as VLDLs. Insulin controls nutrient partitioning via signaling through its cognate receptor in peripheral target organs such as liver, muscle, and adipose tissue and via signaling in the central nervous system (CNS) to orchestrate organ cross talk. While hepatic insulin signaling is known to suppress VLDL production from the liver, it is unknown whether brain insulin signaling independently regulates hepatic VLDL secretion. Here, we show that in conscious, unrestrained male Sprague Dawley rats the infusion of insulin into the third ventricle acutely increased hepatic TG secretion. Chronic infusion of insulin into the CNS via osmotic minipumps reduced the hepatic lipid content as assessed by noninvasive 1H-MRS and lipid profiling independent of changes in hepatic de novo lipogenesis and food intake. In mice that lack the insulin receptor in the brain, hepatic TG secretion was reduced compared with wild-type littermate controls. These studies identify brain insulin as an important permissive factor in hepatic VLDL secretion that protects against hepatic steatosis.
Metabolic Impact of Nonalcoholic Steatohepatitis in Obese Patients With Type 2 Diabetes
Authors: Lomonaco Romina , Bril Fernando , Portillo-Sanchez Paola , Ortiz-Lopez Carolina , Orsak Beverly , Biernacki Diane , Lo Margaret , Suman Amitabh , Weber Michelle H. , Cusi Kenneth
Published: February 2016

OBJECTIVE

Nonalcoholic steatohepatitis (NASH) is increasingly common in obese patients. However, its metabolic consequences in patients with type 2 diabetes mellitus (T2DM) are unknown.

RESEARCH DESIGN AND METHODS

We studied 154 obese patients divided in four groups: 1) control (no T2DM or NAFLD), 2) T2DM without NAFLD, 3) T2DM with isolated steatosis, and 4) T2DM with NASH. We evaluated intrahepatic triglycerides by proton MRS (1H-MRS) and assessed insulin secretion/resistance during an oral glucose tolerance test and a euglycemic-hyperinsulinemic clamp with glucose turnover measurements.

RESULTS

No significant differences among groups were observed in sex, BMI, or total body fat. Metabolic parameters worsened progressively with the presence of T2DM and the development of hepatic steatosis, with worse hyperinsulinemia, insulin resistance, and dyslipidemia (hypertriglyceridemia and low HDL cholesterol) in those with NASH (P < 0.001). Compared with isolated steatosis, NASH was associated with more dysfunctional and insulin-resistant adipose tissue (either as insulin suppression of plasma FFA [33 ± 3 vs. 48 ± 6%] or adipose tissue insulin resistance index [9.8 ± 1.0 vs. 5.9 ± 0.8 mmol/L ⋅ µIU/mL]; both P < 0.03). Furthermore, insulin suppression of plasma FFA correlated well with hepatic steatosis (r = –0.62; P < 0.001) and severity of steatohepatitis (rs = −0.52; P < 0.001). Hepatic insulin sensitivity was also more significantly impaired among patients with T2DM and NASH, both fasting and with increasing insulin levels within the physiological range (10 to 140 µIU/mL), compared with other groups.

CONCLUSIONS

In obese patients with T2DM, the presence of NAFLD is associated with more severe hyperinsulinemia, dyslipidemia, and adipose tissue/hepatic insulin resistance compared with patients without NAFLD. The unfavorable metabolic profile linked to NAFLD should prompt strategies to identify and treat this population early on.
Nonaqueous, Mini-Dose Glucagon for Treatment of Mild Hypoglycemia in Adults With Type 1 Diabetes: A Dose-Seeking Study
Authors: Haymond Morey W. , Redondo Maria J. , McKay Siripoom , Cummins Martin J. , Newswanger Brett , Kinzell John , Prestrelski Steven
Published: February 2016

OBJECTIVE

To evaluate mini-dose glucagon in adults with type 1 diabetes using a stable, liquid, ready-to-use preparation.

RESEARCH DESIGN AND METHODS

Twelve adults with type 1 diabetes receiving treatment with insulin pumps received subcutaneous doses of 75, 150, and 300 μg of nonaqueous glucagon. Plasma glucose, glucagon, and insulin concentrations were measured. At 180 min, subjects received insulin followed in ˜60 min by a second identical dose of glucagon.

RESULTS

Mean (±SE) fasting glucose concentrations (mg/dL) were 110 ± 7, 110 ± 10, and 109 ± 9 for the 75-, 150-, and 300-μg doses, respectively, increasing maximally at 60 min by 33, 64, and 95 mg/dL (all P < 0.001). The post–insulin administration glucose concentrations were 70 ± 2, 74 ± 5, and 70 ± 2 mg/dL, respectively, with maximal increases of 19, 24, and 43 mg/dL post–glucagon administration (P < 0.02) at 45–60 min.

CONCLUSIONS

Subcutaneous, nonaqueous, ready-to-use G-Pen Mini glucagon may provide an alternative to oral carbohydrates for the management of anticipated, impending, or mild hypoglycemia in adults with type 1 diabetes.
Text Message Support for Weight Loss in Patients With Prediabetes: A Randomized Clinical Trial
Authors: Fischer Henry H. , Fischer Ilana P. , Pereira Rocio I. , Furniss Anna L. , Rozwadowski Jeanne M. , Moore Susan L. , Durfee Michael J. , Raghunath Silvia G. , Tsai Adam G. , Havranek Edward P.
Published: February 2016

OBJECTIVE

Although the benefits of in-person Diabetes Prevention Program (DPP) classes for diabetes prevention have been demonstrated in trials, effectiveness in clinical practice is limited by low participation rates. This study explores whether text message support enhances weight loss in patients offered DPP classes.

RESEARCH DESIGN AND METHODS

English- and Spanish-speaking patients with prediabetes (n = 163) were randomized to the control group, which only received an invitation to DPP classes as defined by the Centers for Disease Control and Prevention, or to the text message–augmented intervention group, which also received text messages adapted from the DPP curriculum for 12 months.

RESULTS

Mean weight decreased 0.6 pounds (95% CI −2.7 to 1.6) in the control group and 2.6 pounds (95% CI −5.5 to 0.2) in the intervention group (P value 0.05). Three percent weight loss was achieved by 21.5% of participants in the control group (95% CI 12.5–30.6), compared with 38.5% in the intervention group (95% CI 27.7–49.3) (absolute difference 17.0%; P value 0.02). Mean glycated hemoglobin (HbA1c) increased by 0.19% or 2.1 mmol/mol (95% CI −0.1 to 0.5%) and decreased by 0.09% or 1.0 mmol/mol (95% CI −0.2 to 0.0%) in the control group and intervention participants, respectively (absolute difference 0.28%; P value 0.07). Stratification by language demonstrated a significant treatment effect in Spanish speakers but not in English speakers.

CONCLUSIONS

Text message support can lead to clinically significant weight loss in patients with prediabetes. Further study assessing effect by primary language and in an operational setting is warranted.
Extra-Virgin Olive Oil Reduces Glycemic Response to a High–Glycemic Index Meal in Patients With Type 1 Diabetes: A Randomized Controlled Trial
Authors: Bozzetto Lutgarda , Alderisio Antonio , Giorgini Marisa , Barone Francesca , Giacco Angela , Riccardi Gabriele , Rivellese Angela A. , Annuzzi Giovanni
Published: February 2016

OBJECTIVE

To evaluate whether fat quality, in the context of meals with high– (HGI) or low–glycemic index (LGI), influences postprandial blood glucose (PPG) response in patients with type 1 diabetes.

RESEARCH DESIGN AND METHODS

According to a randomized crossover design, 13 patients with type 1 diabetes on insulin pump consumed two series (HGI or LGI) of meals with the same carbohydrate quantity while differing for amount and quality of fat: 1) low in fat (“low fat”), 2) high in saturated fat (butter), or 3) high in monounsaturated fat (extra-virgin olive oil) (EVOO). Premeal insulin doses were based on insulin–to–glycemic load ratios. Continuous glucose monitoring was performed and 6-h PPG evaluated.

RESULTS

PPG was significantly different between HGI and LGI meals (P = 0.005 for time × glycemic index interaction by repeated-measures analysis [RMA]), being significantly higher during the first 3 h after the HGI meals with a later tendency to an opposite pattern. In the context of HGI meals, PPG was significantly lower after EVOO than after low fat or butter (P < 0.0001 for time × meal interaction by RMA), with a marked difference in the 0- to 3-h glucose incremental area under the curve between EVOO (mean ± SD 198 ± 274 mmol/L × 180 min) and either low fat (416 ± 329) or butter (398 ± 355) (P < 0.05). No significant differences were observed in PPG between the three LGI meals.

CONCLUSIONS

Carbohydrate quality of a mixed meal influences shape and extent of PPG. Besides, using EVOO in a HGI meal attenuates the early postprandial glucose response observed when this meal is consumed with either low fat or butter. Therefore, an optimal prandial insulin administration would require considering, in addition to the quantity of carbohydrates, the quality of both carbohydrate and fat.
Second-Wave White Teacher Identity Studies
Authors: Jupp James C. , Berry Theodorea Regina , Lensmire Timothy J.
Published: February 2016

In this study of White teacher identity literatures, we historicize, define, and advance second-wave White teacher identity studies in education research and teacher education. First, we provide a discussion of methodology used to conduct this study called the synoptic text. Second, we provide an historical account of White teacher identity studies that situates our review of literatures. Third, using the methodology of the synoptic text, we provide a systematic review of White teacher identity studies between 2004 and 2014. Situated within an account of a developing field, we develop the notion of second-wave White teacher identity studies. In our discussion and conclusion, we articulate the pedagogical implications of second-wave White teacher identity studies for education research and teacher education.
Three-Component Reaction between N-Methylimidazole and Activated Acetylenes in the Presence of Kojic Acid or 8-Hydroxyquinoline as CH-Acids
Authors: Pahlavan Pedram , Hassanabadi Alireza
Published: February 2016

We describe a one-pot, three-component reaction between N-methylimidazole and activated acetylenes in the presence of kojic acid or 8-hydroxyquinoline as CH-acids. This affords 2,3-dihydroimidazoles and has advantages such as simple work-up and affording good yields.
A New Monoacylglycerol from the Fruiting Bodies of Gymnopilus Spectabilis
Authors: Suh Won Se , Lee Seoung Rak , Kim Chung Sub , Moon Eunjung , Kim Sun Yeou , Choi Sang Un , Kang Ki Sung , Lee Kang Ro , Kim Ki Hyun
Published: February 2016

Bioassay-guided fractionation and chemical investigation of the MeOH extract of the wild mushroom Gymnopilus spectabilis resulted in the isolation of a new monoacylglycerol, together with five known compounds. The structure of the new compound (2′ S) −1- O-(6,6-dimethoxyhexanol)-glycerol was elucidated on the basis of 1D and 2D NMR (1H and 13C NMR, 1H-1H COSY, HMQC and HMBC) spectroscopic data as well as chemical reactions. The known compounds were identified by comparison of their spectroscopic and physical data with the reported values. The metabolites were evaluated for their anti-proliferative activities against four human tumour cell lines (A549, SK-OV-3, SK-MEL-2 and HCT-15) and for their inhibitory effects on nitric oxide production in lipopolysaccharide (LPS)-activated murine microglial cells.
Dynamic Characterization of Cohesive Material Based on Wave Velocity Measurements
Authors: Sas Wojciech , Gabryś Katarzyna , Soból Emil , Szymański Alojzy
Published: February 2016

The paper presents a description of the dynamic properties of cohesive material, namely silty clays, obtained by using one of the applied seismology methods, the bender elements technique. The authors’ aim was to present the dynamics of a porous medium, in particular an extremely important passage of seismic waves that travel through the bulk of a medium. Nowadays, the application of the bender element (BE) technique to measure, e.g., small strain shear stiffness of soils in the laboratory is well recognized, since it allows for reliable and relatively economical shear wave velocity measurements during various laboratory experiments. However, the accurate estimation of arrival time during BE tests is in many cases unclear. Two different interpretation procedures (from the time domain) of BE tests in order to measure travel times of waves were examined. Those values were then used to calculate shear and compression wave velocities and elastic moduli. Results showed that the dynamic parameters obtained by the start-to-start method were always slightly larger (up to about 20%) than those obtained using the peak-to-peak one. It was found that the peak-to-peak method led to more scattered results in comparison to the start-to-start method. Moreover, the influence of the excitation frequency, the mean effective stress and the unloading process on the dynamic properties of the tested material was studied. In addition, the obtained results highlighted the importance of initial signal frequency and the necessity to choose an appropriate range of frequencies to measure the shear wave velocity in clayey soils.
Investigating Potential Toxicity of Leachate from Wood Chip Piles Generated by Roadside Biomass Operations
Authors: Rex John , Dubé Stephane , Krauskopf Phillip , Berch Shannon
Published: February 2016

Roadside processing of wood biomass leaves chip piles of varying size depending upon whether they were created for temporary storage, spillage, or equipment maintenance. Wood chips left in these piles can generate leachate that contaminates streams when processing sites are connected to waterways. Leachate toxicity and chemistry were assessed for pure aspen (Populus tremuloides Michx.), lodgepole pine (Pinus contorta Dougl.), hybrid white spruce (Picea engelmannii x glauca Parry), and black spruce (Picea mariana (Mill.) Britton) as well as from two wood chipping sites using mixes of lodgepole pine and hybrid or black spruce. Leachate was generated using rainfall simulation, a static 28-day laboratory assay, and a field-based exposure. Leachate generated by these exposures was analyzed for organic matter content, phenols, ammonia, pH, and toxicity. Findings indicate that all wood chip types produced a toxic leachate despite differences in their chemistry. The consistent toxicity response highlights the need for runoff management that will disconnect processing sites from aquatic environments.
Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress
Authors: Dai Jie , Liu Hongmei , Zhou Jun , Huang Kaixun
Published: February 2016

Selenium is an essential micronutrient for humans. Much of selenium’s beneficial influence on health is attributed to its presence within 25 selenoproteins. Selenoprotein R (SelR), known as methionine sulfoxide reductase B1 (MsrB1), is a selenium-dependent enzyme that, like other Msrs, is required for lens cell viability. In order to investigate the roles of SelR in protecting human lens epithelial (hLE) cells against damage, the influences of SelR gene knockdown on D-galactose-induced apoptosis in hLE cells were studied. The results showed that both D-galactose and SelR gene knockdown by siRNA independently induced oxidative stress. When SelR-gene-silenced hLE cells were exposed to D-galactose, glucose-regulated protein 78 (GRP78) protein level was further increased, mitochondrial membrane potential was significantly decreased and accompanied by a release of mitochondrial cytochrome c. At the same time, the apoptosis cells percentage and the caspase-3 activity were visibly elevated in hLE cells. These results suggested that SelR might protect hLE cell mitochondria and mitigating apoptosis in hLE cells against oxidative stress and endoplasmic reticulum (ER) stress induced by D-galactose, implying that selenium as a micronutrient may play important roles in hLE cells.
Organic Nanomaterials and Their Applications in the Treatment of Oral Diseases
Authors: Virlan Maria , Miricescu Daniela , Radulescu Radu , Sabliov Cristina , Totan Alexandra , Calenic Bogdan , Greabu Maria
Published: February 2016

There is a growing interest in the development of organic nanomaterials for biomedical applications. An increasing number of studies focus on the uses of nanomaterials with organic structure for regeneration of bone, cartilage, skin or dental tissues. Solid evidence has been found for several advantages of using natural or synthetic organic nanostructures in a wide variety of dental fields, from implantology, endodontics, and periodontics, to regenerative dentistry and wound healing. Most of the research is concentrated on nanoforms of chitosan, silk fibroin, synthetic polymers or their combinations, but new nanocomposites are constantly being developed. The present work reviews in detail current research on organic nanoparticles and their potential applications in the dental field.
Comparative Evaluation of Total Antioxidant Capacities of Plant Polyphenols
Authors: Csepregi Kristóf , Neugart Susanne , Schreiner Monika , Hideg Éva
Published: February 2016

Thirty-seven samples of naturally occurring phenolic compounds were evaluated using three common in vitro assays for total antioxidant activity (TAC) testing: the Trolox Equivalent Antioxidant Capacity (TEAC), the Ferric Reducing Antioxidant Potential (FRAP) and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, in addition to the Folin-Ciocalteu reagent reactivity (FCR). We found that antioxidant hierarchies depended on the choice of assay and applied ANOVA analyses to explore underlying structure-TAC dependencies. In addition to statistically confirming the empirically established connection between flavonoid ring-B catechol and high TEAC or FRAP, new correlations were also found. In flavonoids, (i) hydroxyl groups on ring-B had a positive effect on all four TAC assays; (ii) the presence of a 3-hydroxyl group on ring-C increased TEAC and FRAP, but had no effect on DPPH or FCR; (iii) Phenolic acids lacking a 3-hydroxyl group had significantly lower FRAP or DPPH than compounds having this structure, while TEAC or FCR were not affected. Results demonstrated that any TAC-based ranking of phenolic rich samples would very much depend on the choice of assay, and argue for use of more than one technique. As an illustration, we compared results of the above four assays using either grapevine leaf extracts or synthetic mixtures of compounds prepared according to major polyphenols identified in the leaves.
Morphology and N2 Permeance of Sputtered Pd-Ag Ultra-Thin Film Membranes
Authors: Fernandez Ekain , Sanchez-Garcia Jose , Viviente Jose , Van Sint Annaland Martin , Gallucci Fausto , Tanaka David
Published: February 2016

The influence of the temperature during the growth of Pd-Ag films by PVD magnetron sputtering onto polished silicon wafers was studied in order to avoid the effect of the support roughness on the layer growth. The surfaces of the Pd-Ag membrane films were analyzed by atomic force microscopy (AFM), and the results indicate an increase of the grain size from 120 to 250–270 nm and film surface roughness from 4–5 to 10–12 nm when increasing the temperature from around 360–510 K. After selecting the conditions for obtaining the smallest grain size onto silicon wafer, thin Pd-Ag (0.5–2-µm thick) films were deposited onto different types of porous supports to study the influence of the porous support, layer thickness and target power on the selective layer microstructure and membrane properties. The Pd-Ag layers deposited onto ZrO2 3-nm top layer supports (smallest pore size among all tested) present high N2 permeance in the order of 10−6 mol·m−2·s−1·Pa−1 at room temperature.
DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older Adults
Authors: Jackson Philippa , Forster Joanne , Bell J. , Dick James , Younger Irene , Kennedy David
Published: February 2016

A number of recent trials have demonstrated positive effects of dietary supplementation with the omega-3 polyunsaturated fatty acids (n-3 PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on measures of cognitive function in healthy young and older adults. One potential mechanism by which EPA, and DHA in particular, may exert these effects is via modulation of cerebral hemodynamics. In order to investigate the effects of DHA alone or provided as one component of a multinutrient supplement (also including Gingko biloba, phosphatidylserine and vitamins B9 and B12) on measures of cerebral hemodynamics and cognitive function, 86 healthy older adults aged 50–70 years who reported subjective memory deficits were recruited to take part in a six month daily dietary supplementation trial. Relative changes in the concentration of oxygenated hemoglobin and deoxygenated hemoglobin were assessed using Near Infrared Spectroscopy (NIRS) during the performance of cognitive tasks prior to and following the intervention period. Performance on the cognitive tasks was also assessed. No effect of either active treatment was found for any of the NIRS measures or on the cognitive performance tasks, although the study was limited by a number of factors. Further work should continue to evaluate more holistic approaches to cognitive aging.
Developed Hybrid Model for Propylene Polymerisation at Optimum Reaction Conditions
Authors: Khan Mohammad , Hussain Mohd , Mujtaba Iqbal
Published: February 2016

A statistical model combined with CFD (computational fluid dynamic) method was used to explain the detailed phenomena of the process parameters, and a series of experiments were carried out for propylene polymerisation by varying the feed gas composition, reaction initiation temperature, and system pressure, in a fluidised bed catalytic reactor. The propylene polymerisation rate per pass was considered the response to the analysis. Response surface methodology (RSM), with a full factorial central composite experimental design, was applied to develop the model. In this study, analysis of variance (ANOVA) indicated an acceptable value for the coefficient of determination and a suitable estimation of a second-order regression model. For better justification, results were also described through a three-dimensional (3D) response surface and a related two-dimensional (2D) contour plot. These 3D and 2D response analyses provided significant and easy to understand findings on the effect of all the considered process variables on expected findings. To diagnose the model adequacy, the mathematical relationship between the process variables and the extent of polymer conversion was established through the combination of CFD with statistical tools. All the tests showed that the model is an excellent fit with the experimental validation. The maximum extent of polymer conversion per pass was 5.98% at the set time period and with consistent catalyst and co-catalyst feed rates. The optimum conditions for maximum polymerisation was found at reaction temperature (RT) 75 °C, system pressure (SP) 25 bar, and 75% monomer concentration (MC). The hydrogen percentage was kept fixed at all times. The coefficient of correlation for reaction temperature, system pressure, and monomer concentration ratio, was found to be 0.932. Thus, the experimental results and model predicted values were a reliable fit at optimum process conditions. Detailed and adaptable CFD results were capable of giving a clear idea of the bed dynamics at optimum process conditions.
Development of Poly(ɛ-caprolactone) Scaffold Loaded with Simvastatin and Beta-Cyclodextrin Modified Hydroxyapatite Inclusion Complex for Bone Tissue Engineering
Authors: Lee Jung , Kim Ji , Bae Min , Park Su , Balikov Daniel , Sung Hak-joon , Jeon Hoon , Park Hun , Um Soong , Lee Kook , Kwon Il
Published: February 2016

In this study, we developed poly(ɛ-caprolactone) (PCL) 3D scaffolds using a solid free form fabrication (SFF) technique. β-cyclodextrin (βCD) was grafted to hydroxyapatite (HAp) and this βCD grafted HAp was coated onto the PCL scaffold surface, followed by drug loading through an inclusion complex interaction between the βCD and adamantane (AD) or between βCD and simvastatin (SIM). The scaffold structure was characterized by scanning electron microscopy (SEM). The release profile of simvastatin in the β-CD grafted HAp was also evaluated. Osteogenic differentiation of adipose-derived stromal cells (ADSCs) was examined using an alkaline phosphatase activity (ALP) assay. The results suggest that drug loaded PCL-HAp 3-D scaffolds enhances osteogenic differentiation of ADSCs.
L-Band Polarimetric Target Decomposition of Mangroves of the Rufiji Delta, Tanzania
Authors: Brown Ian , Mwansasu Simon , Westerberg Lars-Ove
Published: February 2016

The mangroves of the Rufiji Delta are an important habitat and resource. The mangrove forest reserve is home to an indigenous population and has been under pressure from an influx of migrants from the landward side of the delta. Timely and effective forest management is needed to preserve the delta and mangrove forest. Here, we investigate the potential of polarimetric target decomposition for mangrove forest monitoring and analysis. Using three ALOS PALSAR images, we show that L-band polarimetry is capable of mapping mangrove dynamics and is sensitive to stand structure and the hydro-geomorphology of stands. Entropy-alpha-anisotropy and incoherent target decompositions provided valuable measures of scattering behavior related to forest structure. Little difference was found between Yamaguchi and Arii decompositions, despite the conceptual differences between these models. Using these models, we were able to differentiate the scattering behavior of the four main species found in the delta, though classification was impractical due to the lack of pure stands. Scattering differences related to season were attributed primarily to differences in ground moisture or inundation. This is the first time mangrove species have been identified by their scattering behavior in L-band polarimetric data. These results suggest higher resolution L-band quad-polarized imagery, such as from PALSAR-2, may be a powerful tool for mangrove species mapping.
The Principle of Integration in International Sustainable Development Law (ISDL) with Reference to the Biological Weapons Convention (BWC)
Authors: Majid Marina , Abdullah Nor , Noor Siti , Gan Chan
Published: February 2016

The Biological Weapons Convention (BWC) does not explicitly refer to sustainable development despite the fact that other United Nations (UN) disarmament documents prescribe that international environmental law principles and sustainable development be considered among arms control agreements. This study’s objective is to utilize the principle of integration’s three components of environmental, economic, and social development, as found in the International Sustainable Development Law (ISDL) from the New Delhi Declaration (Delhi Declaration) of Principles of International Law Relating to Sustainable Development, in order to evaluate whether the BWC contains such components; thereby, making it possible for the BWC to contribute to sustainable development. The methodology of this study is necessarily qualitative, given that it is a socio-legal research that relies on international agreements such as the BWC, declarations, resolutions, plans of implementation, other non-binding documents of the UN, and secondary resources—all of which are analyzed through a document analysis. The results show that the BWC addresses the environment (Article II), prohibits transfers relating to export controls, international trade, and economic development (Article III), while at the same time, covering social development concerns, health, and diseases that make up the international social law (Article X). Since the BWC is found to be capable of contributing to sustainable development, it is concluded that ISDL cannot be restricted to international environmental, economic, and social law, but should be expanded to include international arms control law.
INTERACTIONS OF THE INFRARED BUBBLE N4 WITH ITS SURROUNDINGS
Authors: Liu Hong-Li , Li Jin-Zeng , Wu Yuefang , Yuan Jing-Hua , Liu Tie , Dubner G. , Paron S. , Ortega M. E. , Molinari Sergio , Huang Maohai , Zavagno Annie , Samal Manash R. , Huang Ya-Fang , Zhang Si-Ju
Published: February 2016

The physical mechanisms that induce the transformation of a certain mass of gas in new stars are far from being well understood. Infrared bubbles associated with H ii regions have been considered to be good samples for investigating triggered star formation. In this paper we report on the investigation of the dust properties of the infrared bubble N4 around the H ii region G11.898+0.747, analyzing its interaction with its surroundings and star formation histories therein, with the aim of determining the possibility of star formation triggered by the expansion of the bubble. Using Herschel PACS and SPIRE images with a wide wavelength coverage, we reveal the dust properties over the entire bubble. Meanwhile, we are able to identify six dust clumps surrounding the bubble, with a mean size of 0.50 pc, temperature of about 22 K, mean column density of 1.7 × 1022 cm−2, mean volume density of about 4.4 × 104 cm−3, and a mean mass of 320 M
⊙. In addition, from PAH emission seen at 8 μm, free–free emission detected at 20 cm, and a probability density function in special regions, we could identify clear signatures of the influence of the H ii region on the surroundings. There are hints of star formation, though further investigation is required to demonstrate that N4 is the triggering source.
HERSCHEL OBSERVATIONS OF MAJOR MERGER PAIRS AT z = 0: DUST MASS AND STAR FORMATION
Authors: Cao Chen , Xu Cong Kevin , Domingue Donovan , Buat Veronique , Cheng Yi-Wen , Gao Yu , Huang Jiasheng , Jarrett Thomas H. , Lisenfeld Ute , Lu Nanyao , Mazzarella Joe , Sun Wei-Hsin , Wu Hong , Yun Min S. , Ronca Joseph , Jacques Allison
Published: February 2016

We present Herschel PACS and SPIRE far-infrared (FIR) and submillimeter imaging observations for a large K-band selected sample of 88 close major-merger pairs of galaxies (H-KPAIRs) in 6 photometric bands (70, 100, 160, 250, 350, and 500 μm). Among 132 spiral galaxies in the 44 spiral–spiral (S+S) pairs and 44 spiral–elliptical (S+E) pairs, 113 are detected in at least 1 Herschel band. The star formation rate (SFR) and dust mass (M
dust) are derived from the IR SED fitting. The mass of total gas (M
gas) is estimated by assuming a constant dust-to-gas mass ratio of 0.01. Star-forming spiral galaxies (SFGs) in S+S pairs show significant enhancements in both specific star formation rate (sSFR) and star formation efficiency (SFE), while having nearly the same gas mass compared to control galaxies. On the other hand, for SFGs in S+E pairs, there is no significant sSFR enhancement and the mean SFE enhancement is significantly lower than that of SFGs in S+S pairs. This suggests an important role for the disk–disk collision in the interaction-induced star formation. The M
gas of SFGs in S+E pairs is marginally lower than that of their counterparts in both S+S pairs and the control sample. Paired galaxies with and without interaction signs do not differ significantly in their mean sSFR and SFE. As found in previous works, this much larger sample confirms that the primary and secondary spirals in S+S pairs follow a Holmberg effect correlation on sSFR.
Physicochemical characterization and quality of cold-pressed peanut oil obtained from organically produced peanuts from Macedonian “Virginia” variety
Authors: Kostadinović Veličkovska S. , Mitrev S. , Mihajlov Lj.
Published: February 2016

The physicochemical characterization and quality of cold pressed peanut edible oil from the “Virginia” variety, organically produced from the region of Macedonia, were examined in this work for the first time. The fatty acid composition of the oil showed almost equal levels of oleic and linoleic acids with an abundance of 34.19±0.01 and 36.13±0.01%, respectively. The most dominant saturated fatty acid was palmitic acid with a level of 10.06±0.00%. The level of tocopherols and other vitamin-E-related compounds was in strong agreement with the antioxidant activity of the oils measured by the DPPH assay. Almost equal amounts of α and γ tocopherols indicated an antioxidant potential of 288.63±59.78 mg·L−1 α-tocopherol. Phytosterols, as minor compounds present in the oils, can be additional antioxidants responsible for the health benefits of this oil in human nutrition. The four major pytosterols were β-sitosterol (1812.21±22.17 mg·kg−1 oil), champesterol (320.55±17.07 mg·kg−1 oil), Δ5-avenasterol (236.16±14.18 mg·kg−1) and stigmasterol (133.12±12.51 mg·kg−1 oil). Induction time, Peroxide number, FFA and specific extinction (K232 and K270, values 1.82 and 0.22) gave us an indication of the oxidative stability of cold pressed peanut oil.
Effect of the amount of chestnuts in the diet of Celta pigs on the fatty acid profile of dry-cured lacon
Authors: De Jesús M. C. , Domínguez R. , Cantalapiedra J. , Iglesias A. , Lorenzo J. M.
Published: February 2016

The effect of including chestnuts in the formulation of the feed (0, 15 and 25% chestnut) on the fatty acids of dry-cured lacon from Celta pigs was studied. The inclusion of chestnuts decreases the saturated fatty acid content (SFA) and the monounsaturated fatty acid content (MUFA). With regards to the polyunsaturated fatty acids (PUFA), the lacon from animals fed with chestnuts presented higher values of total PUFA, n6 PUFAs and n3 PUFAs. This is related to the fact that chestnut diets had the highest amounts of essential fatty acids (C18:2n6 and C18:3n3), therefore the lacon from chestnut-fed animals also presented higher amounts of these fatty acids. According to nutritional ratios, lacon obtained from chestnut-fed pigs was healthier than the one obtained from pigs fed on commercial feed. The main conclusion is that including chestnuts in the diet allows us to obtain healthier dry-cured meat products.
Variation in the proximate composition and fatty acid profile recovered from Argentine hake (Merluccius hubbsi) waste from Patagonia
Authors: Cretton M. , Rost E. , Mazzuca Sobczuk T. , Mazzuca M.
Published: February 2016

The fish processing operations in Patagonia produce large amounts of waste. The main fishery resource in Argentina is the Argentine hake (Merluccius hubbsi). The ports of the province of Chubut (the most important of which are Puerto Madryn, Rawson and Comodoro Rivadavia), together with Caleta Paula Port (province of Santa Cruz), in the Argentine Patagonia, capture more than 82,000 tons of hake annualy, 80% of which are of M. hubbsi, which is mostly converted into fillets. From this capture, about 2,296 tons of liver would be available for the extraction of oil. To promote the recovery and industrial use of fish oil, in the present study, we determined the variation in the proximate composition and fatty acid profile of Argentine hake waste from the ports mentioned above at different catch times. Proximate composition was determined according of the Official Methods of Analysis (AOAC). Fatty acid profile was analyzed by gas chromatography of the fatty acid methyl esters (FAMEs). A standard mixture of FAMEs was run under identical conditions to identify the compounds on the basis of their retention times. Fatty acids were quantified using heptadecanoic acid (C17:0) as internal standard. The highest lipid recovery (27.0 to 41.8% of total lipids) was obtained from the liver fraction. Palmitic acid (C16:0), oleic acid (18:1 n9), docosahexaenoic acid (22:6 n3), eicosapentaenoic acid (20:5 n3) and palmitoleic acid (16:1) were the main constituents. Protein levels in viscera without livers (V-L) were higher than those in the liver. The extraction of marine fish oil and the production of fish offal meal from waste from fish factories would contribute to the sustainability of the regional industry, because it would also decrease the volume of waste, with benefits to the environment.