bluuebunny/crossref_metadata_2025 huggingface dataset:
Ulcerative colitis-associated neoplasms often harbor poor prognostic histologic components with low detection by biopsy
Authors: Sakakibara Ryoya , Sugimoto Shinya , Takabayashi Kaoru , Kiyohara Hiroki , Wakisaka Yusuke , Kaieda Yuta , Kawaida Miho , Yoshimatsu Yusuke , Sujino Tomohisa , Hosoe Naoki , Kato Motohiko , Shimoda Masayuki , Mikami Yohei , Iwao Yasushi , Kanai Takanori
Published: May 2024

Background/Aims: Poorly differentiated adenocarcinoma, signet-ring cell carcinoma, and mucinous adenocarcinoma (por/sig/muc), which are considered to be histologic subtypes with a poor prognosis, occur more frequently with colitis-associated cancer than with sporadic tumors. However, their invasiveness and manifestations are unclear. This study aimed to determine the prevalence of the por/sig/muc component in ulcerative colitis-associated neoplasms (UCANs) and its association with invasiveness and to clarify its clinicohistologic and endoscopic features.Methods: This retrospective observational study included patients diagnosed with ulcerative colitis-associated high-grade dysplasia or adenocarcinoma from 1997 to 2022 who were divided according to the presence or absence of a por/sig/muc component.Results: Thirty-five patients had UCAN with a por/sig/muc component and 66 had UCAN without this component. The 5-year survival rate was significantly lower in the por/sig/muc group than in the tub group (67% vs. 96%, P= 0.001), which was attributed to disease above stage III and depth to below the subserosa. Biopsy-based diagnosis before resection detected a por/sig/muc component in only 40% of lesions (14/35). Lesions with a por/sig/muc component were prevalent even in the early stages: stage 0 (4/36, 11%), I (8/20, 40%), II (7/12, 58%), III (10/14, 71%), and IV (6/8, 75%).Conclusions: This is the first investigation that shows UCANs with a por/sig/muc component tended to be deeply invasive and were often not recognized preoperatively. Endoscopists should be aware that UCAN often has a por/sig/muc component that is not always recognized on biopsy, and the optimal treatment strategy needs to be carefully considered.
Inserção de cateter de Shilley para manejo de grande abscesso do músculo psoas em mulher jovem: relato de caso
Authors: Mesquita Luis Eduardo Sepulveda , Silva Gabriely Lorrany de Oliveira , Carneiro Beatriz Ribeiro , Afonso Bruno Henrique Campos , Mesquita Luis Flávio Vilela de
Published: May 2024

O abscesso de músculo psoas é uma patologia não muito frequente, que está relacionada a uma infecção primária ou secundária que ocasiona a formação de coleção purulenta na anatomia do músculo psoas que pode ocasionar inúmeras consequências. Este trabalho apresenta um caso raro para literatura, analisando a fisiopatologia, diagnóstico e tratamento, dando enfoque no acometimento de paciente do sexo feminino e jovem, além da utilização de Cateter de Shilley para manejo e sua eficácia no caso.
Bimbingan Teknis dalam upaya Peningkatan Kapasista Guru Paud di Desa Mahato
Authors: Fitria Rahmi , Handayani Eka Yuli , Wulandari Sri , Antoni Rivi
Published: May 2024

Pandangan global ini tercermin dari pengakuan berbagai pemerintah di dunia akan pentingnya fungsi dan peran PAUD baik bagi anak usia dini maupun bangsa. Target Agenda Pendidikan 2030 untuk PAUD adalah memastikan seluruh anak laki-laki dan perempuan memperoleh akses terhadap perkembangan, perawatan dan pendidikan pra-SD (PAUD) yang bermutu untuk menjamin kesiapan memasuki pendidikan dasar. Di Indonesia upaya mencapai target tersebut sudah dimulai dengan Program Satu Desa Satu PAUD. Dalam satu nafas dengan Deklarasi Dakar dan SDGs di atas, Pemerintah Indonesia melakukan berbagai upaya untuk menyediakan akses terhadap layanan PAUD bagi seluruh anak usia dini di Indonesia. Terdapat banyak tenaga pendidik yang belum mengerti tentang penguasaan kelas dan pengasuhan bersarkan usia di Desa Mahato
Sosialisasi Keselamatan Instalasi Listrik Bertegangan Rendah Kepada Warga Peduli Sekitar (Wa Pesek) Kecamatan Medan Johor
Authors: Fadlan Siregar Muhammad , Satria Habib , Dayana Indri , Mungkin Moranain , Maizana Dina , Anwar Syaputra Sofyan , Fitriani Ayu , Syafriwel  , Permata Sari Siregar Ade
Published: May 2024

Instalasi listrik harus sesuai dengan ketentuan Puil 2011 dimana menjamin kehandalan instalasi listrik sesuai tujuan pada pengguna listrik PLN. Instalas yang baik sesuai dengan ketentuanakan mencegah timbulnya bahaya  kebakaran dan sentuhan langsung, penggunaan pada instalasi listrik yang dilengkapi dengan perlindungan dan keamanan seperti mini circuit beker, saklar diferensial (RCD), dan sistem grounding yang baik akan membantu melindungi rumah dari risiko kebakaran atau kecelakaan listrik. Hindari penggunaan kabel yang rusak atau terlalu panjang. Menggunakan alat - alat pelindung diri (APD) seperti sarung tangan dan sepatu khusus saat melakukan pekerjaan yang melibatkan penggunaan energi listrik keselamatan kerja listrik adalah tanggung jawab kita bersama. patuhi syarat-syarat keselamatan listrik.
Edukasi Tentang Cita-Cita dan Masa Depan Melalui Papan Cita Sebagai Upaya Mengatasi Kurangnya Minat Belajar di SDN 3 Bandar Baro
Authors: Safriana Safriana , Hajrayanti Lili , Azriansyah Akmal , Da’are Maesa Arik Uru , Padlu Rohman Cecep , Puspasari Cindenia , Irfan Ade
Published: May 2024

Kurangnya edukasi dan dukungan dari lingkungan membuat  kalangan siswa di daerah pelosok, salah satunya di SDN 3 Banda Baro mendorong para mahasiswa kelompok 1 Meutuah untuk melakukan kontribusi sosial di sekolah dasar ini dengan tujuan memotivasi dan mendorong para siswa untuk melanjutkan pendidikan hingga jenjang kuliah. Metode yang digunakan adalah dengan  mengajak para siswa membuat papan cita-cita. Secara umum kegiatan pengabdian di SDN 3 Banda baro berjalan lancar, kondusif dan diterima dengan baik oleh pihak sekolah, pendampingan siswa dalam kontribusi sosial telah dapat meningkatkan antusias dan motivasi belajar siswa untuk meraih cita-cita, dan dengan adanya project papan cita-cita dan gantungan profesi siswa akan lebih termotivasi untuk dapat mengembangkan pola pikir dan penampilannya dalam belajar sehingga nantinya akan timbul profesionalitas cita-cita yang siswa kelas 5 harapkan
Product of generalized derivations of order 2 with derivations acting on multilinear polynomials with centralizing conditions
Authors: Kuila Swarup , Dhara Basudeb
Published: May 2024

Let R be a prime ring with char(R) 6= 2. Suppose that f(x1,... , xn) be a noncentral multilinear polynomial over C, G be nonzero generalized derivation of R and d a nonzero derivation of R. In this paper we describe all possible forms of G in the given case.
Stability analysis of an age structured population model with fractional time derivative
Authors: Cherkaoui Fatima , El Asraoui Hiba , Hilal Khalid
Published: May 2024

In this paper, we analyse the large time behaviour in a fractional nonlinear model of population daynamics with age dependent. We show the existence and uniqueness of the solution by using the method of seperation of variables, and we studied the Ulam-Hyers stability of the model.
Reverse takotsubo after emotional distress and catecholamine bolus
Authors:   Critical Care Program, Universidad Finis Terrae, Chile., Andres Giglio
Published: May 2024

A patient in his 40s was referred from a primary care facility to the emergency department because of chest pain, hypotension which was managed with a bolus of adrenaline, and diffuse ST depression on electrocardiography (ECG) after a life event with a high emotional impact. The patient was admitted with persistent hypotension and a second ECG with persistent ST depression; however, isobiphasic T was observed in some of the precordial leads. Given the evolving ECG, thoracic pain, and elevated troponin levels, the patient was admitted for percutaneous coronary angiography (PCI), considering the risk of Acute Coronary Syndrome. The latter reports coronary arteries without lesions but ventriculography with reverse Takotsubo morphology (Figure 1).
A large retroperitoneal mass in a elderly male: A case report
Authors:   Assistant Professor, Department of Surgery, Military Hospital Ahmednagar, Maharashtra, India., Devadoss Yelamanchi Hanock
Published: May 2024

Pain abdomen and distention of abdomen in elderly male, which is chronic in nature, draws attention to multiple differential diagnoses, especially if the individual has multiple comorbidities in the form of Systemic Hypertention, dyslipidemia. Ruling out aortic, renal, and gut pathologies clinically, biochemically and radiologically, the suspicion increases towards the intra-abdominal pathology [1]. The patient initially had swelling in left hypochondriac area which gradually increased over a period of 12 years and extended towards both lumbar regions and right iliac fossa associated with dull aching pain around left hypochondriac area [2]. Patient denied history of previous abdominal surgeries. Surgical removal is treatment of choice for a symptomatic patient with retroperitoneal mass. However, the controversy surrounding the surgical removal goes with histopathological outcome of the specimen [3]. As a norm the retroperitoneal tumors are slow growing and the chances of malignant transformation increases with size and duration, high suspicion of sarcomatous transformational pathology should be kept in mind [4].
Simultaneous medullary and papillary thyroid carcinoma associated with a primary renal carcinoma: Case report and review of literature
Authors:   ENT Department and Head and Neck Surgery, Fattouma Bourguiba Hospital of Monastir, Tunisia., Rachida Bouatay
Published: May 2024

Background: The association of primary two thyroid cancer (TC) and papillary renal carcinoma is an uncommon situation and only few cases have been reported. Case presentation: We report the case of a 49-year-old man with a papillary, medullary thyroid cancer in whom a papillary renal cancer was subsequently discovered. The patient was treated with total thyroidectomy and dissection of lymph nodes followed by radiotherapy and radioactive iodine. Conclusions: The simultaneous thyroid and renal carcinomas remains a subject of research, further investigations including tumor mutational status and histopathologic evaluation for each primary tumor are needed.
Vesical calculus: A harbinger for posterior urethral valve?
Authors:   Department of Pediatric Surgery, BL Taneja Block, Room No. 428, Maulana Azad, Medical College Campus, New Delhi-110002, India., Saxena Gaurav
Published: May 2024

Bladder stones are of two varieties, primary which are not associated with Urinary Tract Infection (UTI), Bladder Outlet Obstruction (BOO) or foreign bodies and secondary bladder stones which are associated with either or all of the above-mentioned entities. We report three cases of male patients with bladder calculi without any specific history suggestive of BOO since birth. In one of them, posterior urethral valve was found to be the cause of urinary leak on post-operative day 6th after cystolithotomy. In the other two, we had performed cystoscopy before planned cystolithotomy. We recommend through this article that all boys with bladder stones should have diagnostic cystoscopy, especially where endo-urology is available, before proceeding for cystolithotomy.
Embolization and bleeding in patients with anticardiolipin antibodies
Authors:   Department of Interventional medicine, The First Hospital of Lanzhou University, China., Wenhui Wang
Published: May 2024

The patient, a 32-year-old male, was positive for anti-cardiolipin antibody syndrome and had a history of smoking for 15 years. He underwent “inferior vena cava filter implantation + catheter hemolysis” 10 years ago due to deep vein thrombosis of the right lower limb. After surgery, he continued to take farwarin and aspirin orally. Three years ago, due to thrombosis again, intravenous thrombolysis was performed in the lower extremity. After surgery, pharhualin was taken orally continuously. Massive hemoptysis occurred after intense exercise and eating spicy stimulating food 5 months ago. DSA showed abnormal bleeding in the right bronchial artery and right internal thoracic artery, so 300-500 um microsphere was used to embolize the peripheral artery. 350-560 um PVA granules embolized bronchial arteries; Three months ago, due to the recurrence of hemoptysis after oral administration of TCM blood-promoting drugs, angiography showed an increase in the number of responsible arteries, abnormal bleeding of the left bronchial artery and the right upper lobar bronchial artery of the lung segment, the formation of the middle and lower lobar bronchial artery of the right lung segment and the formation of collateral circulation of the right internal thoracic artery. Embolization of the above arteries was performed, and the patient recovered well after surgery and was discharged from hospital.
The clinical observation of DRG pulsed radiofrequency treatment for chronic musculoskeletal disease
Authors:   The Pain Department of Shougang Shuigang Hospital, Guizhou, 553000, China., Zuo Zhengmin , Wu Ting ,   The Pain Department of Shougang Shuigang Hospital, Guizhou, 553000, China.
Published: May 2024

Objective: To observe the clinical effect of Chronic Musculoskeletal Pain (CMP). Methods: 80 CMP patients admitted to our department from January 2022 to June 2023 were selected as the pain improvement after pulse radiofrequency treatment. Results: The total response rate at 1 week and 4 weeks was 91.25% and 97.50%, respectively. The excellent rate at 4 weeks after treatment was significantly higher than at 1 week after treatment. VAS scores were significantly lower at 1 week and 4 weeks after treatment than before treatment (P<0.05). Conclusion: Pulsed radiofrequency therapy for CMP has a significant clinical effect, significant pain improvement, and significantly improved quality of life. It is a widely used interventional therapy in chronic pain.
Surveillance on avian influenza and new castle disease in rift valley water body areas of Ethiopia
Authors:   National Animal Health Diagnostic and Investigation Center, Ethiopia., Belaineh Redeat
Published: May 2024

HPAI (High Pathogenic Avian Influenza) is one of the most serious public-health threats to arise from the animal reservoir. The diseases can kill up to 90% of a flock and generate epidemics that can spread quickly, wreaking havoc on the poultry business and putting severe trade restrictions in place. New Castle disease (NCD) is also a persistent threat to the poultry business and is a limiting illness for poultry farmers around the world. It is one of the most serious diseases in Ethiopia, with high mortality and huge economic losses. For this and the like purposes risk-based surveillance was conducted in selected sites in Oromia, Amhara, and Southern Nation Nationality Peoples Region (SNNPR) rift valley water body areas and 5-10 km radius districts from January to April 2019. The goal was to assess the presence or absence of Highly Pathogenic Avian Influenza (HPAI) and New Castle Disease (NCD) in migratory birds and domestic chicken in water body areas, as well as to assess the level of community awareness in the study areas. Total 6866 samples were collected, including 819 sera samples and 1836 tracheal and cloacal swab samples from backyard domestic chickens within a 5-10 km radius of rift valley lakes, and 4211 fecal droplet samples from wild/migratory birds. Avian influenza serum samples tested by HA/HI and Fecal droplet samples tested by RT PCR came back negative. The results for NDV swab 1336 samples tested by RT PCR were 182 samples positive, and 819 samples tested by HI were 72 samples positive. In the public health aspect, a questionnaire survey was completed by 180 members of the respective community. As a result, the respondents have a solid understanding of the migratory birds that visit their area.
A case of moyamoya disease
Authors:   Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China., Zou Chaojie
Published: May 2024

Moyamoya Disease (MMD) is a rare cause of stroke with progressive stenosis of the end of the internal carotid artery and compensatory capillaries. The symptoms and course of moyamoya disease depend on the age of the patient at the time of symptom onset and the type of first episode (ischemic or hemorrhagic), but vary in severity from transient ischemic episodes to persistent neurological deficits [1].
Knowledge, attitudes and practices of health care workers regarding the prevention of nosocomial infections in the ICU
Authors:   Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon., RS Bengono Bengono , B Jemea ,   Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon., AL Amengle ,   Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon., F Ndom Ntock ,   Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon., C Iroume ,   Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon., G Lemoula ,   Intensive Care Unit, Yaoundé Gynaeco-Obstetric and Pediatric Hospital, Yaoundé, Cameroon., S Kona Ngondo ,   Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon., J Ze Minkande ,   Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, Yaoundé, Cameroon.
Published: May 2024

Background: The aim of this study was to evaluate the knowledge, attitudes and practices of health care personnel regarding the prevention of nosocomial infections in the ICU. Methods: This was a cross-sectional, descriptive, study that took place in the intensive care units of two university hospitals of Yaoundé. Our study was conducted in two phases: the first phase consisted of the administration of an anonymous, self-administered questionnaire to the health care personnel who agreed to participate in the study, and the second phase permitted us to evaluate the personnel’s’ practices using the WHO model observation form. Data analysis was done using CS-Pro version 7.5, Microsoft® Office Excel 2013 and S.P.S.S. 21.0. Results: Our sample consisted of 60 practitioners. The sex-ratio was 0.54. The mean age was 38.35 ± 8.86 years. Most of the staff had been in the ICU for less than 5 years and only 35% of the staff had received at least one continuing education course on infection control measures. Good knowledge was found in 70% of the staff assessed, 60% had incorrect attitudes, and 63% had inadequate practices. The rate of compliance with good hygiene practices was 55.2%. Conclusion: Knowledge were mean, attitudes were wrong and practices were inadequate regarding the management of nosocomial infections in the ICU.
Influence of Silver Nanoparticles on Germinated and Microwaved Chia Seeds (Salvia Hispanica L)
Authors:   Department of Food Science and Technology, Faculty of Food Science and Nutrition, Bahauddin Zakariya University, 60700, Multan, Punjab, Pakistan., Sattar Dur-e-Shahwar , Mubarik Sameen ,   Department of Human Nutrition and Dietetics, Faculty of Food Science and Nutrition, Bahauddin Zakariya University, 60700, Multan, Punjab, Pakistan., Sattar Javerya ,   Senior Registrar, Dow University of Health and Sciences, Karachi, Pakistan., Mubarik Saman ,   Institute of Chemical Sciences, Bahauddin Zakariya University, 60700, Multan, Punjab, Pakistan.
Published: May 2024

This study thoroughly investigated the impact of 60 ppm silver nanoparticles (AgNPs) on the germination process of chia seeds (Salvia Hispanica L.) and an examination of subsequent modifications induced by microwave treatment on AgNP-exposed seeds. The research findings highlighted a significant enhancement in seed germination percentage peaking at 81.67% on the fifth day particularly when exposed to a concentration of 60 ppm AgNPs. Concurrently, radicle length experienced a substantial increase indicative of improved early seedling growth. Morphological study was also studied by scanning electron microscopy. Results indicated that samples treated with microwave showed shrinkage and the samples treated with germination samples showed expansion. Furthermore, investigation of bioactive compounds indicated increased concentrations of total phenolic content and total flavonoids content in samples germinated with AgNPs simultaneously with increased antioxidant activity. In a nutshell, this study provided a comprehensive understanding of the impacts of 60 ppm AgNPs on germination and microwave treatment on chia seeds. The far-reaching implications span across agriculture, food science, and nutritional domains, providing a strong basis for potential future applications and further scientific examination.
Seizures in Multiple Sclerosis are, above all, a Matter of Brain Viability
Authors:   District Hospital Lohr, Psychiatric Clinic Aschaffenburg, Am Hasenkopf 3, 63739 Aschaffenburg, Germany, Kavčič Anamarija , E Hofmann Werner ,   Outpatient Clinic for Neurology, Psychiatry and Psychotherapy, Weichgasse 5, 63868 Großwallstadt, Germany.
Published: May 2024

Objectives: Most patients with Multiple Sclerosis (MS) never have a seizure, although they are at risk for seizures since the onset of MS. This paradox leads us to suppose that MS plays a minor role in seizure generation and epileptogenesis. Methods: Qualitative study using data triangulation and inductive content analysis. A comprehensive literature search was carried out in four electronic databases (MEDLINE, Embase, Web of Science, and Google Scholar). Results: In MS patients, unprovoked seizures occur rarely (in about 3 percent of cases). Pediatric MS involves seizures more common than adult or late-onset MS. In general, children with seizures do not have poorer MS prognoses than children without seizures. Contrary to the general population, seizures do not peak in older MS patients. Since the use of disease-modifying therapies in the treatment of MS (i.e., since 1993), the frequency of seizures in MS patients has not changed considerably. Epilepsy syndrome cannot be recognized in MS patients with seizures. As a rule, seizures in MS are not difficult to treat. A sudden unexpected death in MS patients with seizures has not been observed more commonly than in the general epilepsy population. A disruption of the blood–brain barrier is the most obvious proconvulsive factor of MS. However, neither MS relapses nor a high rate of MS relapses is normally accompanied by seizures. Structural brain abnormalities usually accumulate over the course of MS. However, a high brain magnetic resonance imaging lesion load does not have a substantial impact on seizure occurrence in MS. Conclusion: MS does not have a major role in seizure generation and epileptogenesis. In most cases, the seizure-promoting effects of MS can be successfully counteracted by the brain´s protective mechanisms.
REPRESENTASI NILAI YANG TERKANDUNG DALAM GONG & MOKO, MUSIK TRADISIONAL MASYARAKAT ADAT SUKU ABUI KABUPETN ALOR DI SANGGAR KENARI SIKUMANA
Authors: Mone Orista Y.D. , Letma Imanuel , Olang Musa Sir
Published: May 2024

Penelitian ini membahas tentang salah satu music tradisional yang berada di suku Abui, kabupaten Alor Nusa Tenggara Timur Indonesia. Sebagaimana kita ketahui bahwa kebudayaan di Indonesia terbilang sangat unik dan beragam dan terbilang sebagai Negeri multi etnik. Berbagai kekhasan daerah baik music, tarian maupun tradisi menjadi identitas Nusantara sehingga meneliti dan mencari hal-hal terkait kebudayaan menjadi hal yang sangat penting bagi seluruh masyarakatnya. Pada penelitian ini, peneliti berusaha untuk mengungkapkan hal-hal atau nilai-nilai dibalik gong dan moko sebagai music tradisional serta menjadi benda zaman prasejarah yang masih terus diwarikan dari generasi ke generasi hingga saat ini. Pada penelitian ini, Peneliti menggunakan metode kualitatif untuk mengumpulkan data sebaik mungkin sesuai dengan langkah-langkah sebagaimana adanya. Berbagai teori dan kajian kepustakaan juga dipakai untuk menjadi acuan dalam penelitian ini agar penelitian ini juga memiliki dasar secara akademis. Etnomusikology dan semiotika menjadi teori yang kuat dalam penelitian karena dalam penelitian ini secara khusus membahas fungsi, nilai maupun makna yang terdapat di dalam alat music gong dan moko bagi masyarakat adat suku Abui kabupaten Alor. Gong dan Moko memiliki peran yang sangat penting dalam kehidupan masyarakat suku Abui karena beragam fungsi yang dimilikinya dan hal itu juga yang membuat banyak masyarakat terus berusaha untuk mengoleksinya hingga saat ini.
Perceived opportunities of clinical reasoning learning in postgraduate psychiatry training: Trainees’ and faculty’s perspectives
Authors: Albahari Dalia
Published: May 2024

Background: Learning clinical reasoning is less effective in isolation of clinical environments because contextual factors are a significant component in the clinical reasoning process. This study investigated the differences in opinions between novice and expert clinicians on learning clinical reasoning in the workplace.

Materials and Methods: The author used a cross-sectional online survey design to investigate the perceived learning of six clinical reasoning skills in 13 learning opportunities. Questionnaires were emailed to 41 postgraduate psychiatry trainee doctors and 37 faculty members. Data were analyzed descriptively. The Chi-square test was used to compare the responses of the two groups. Statistical significance was set at P < 0.05.

Results: The combined response rate was 73.07%. The two groups perceived the learning of advanced clinical reasoning skills to be lower than that of basic skills. There were significant differences in the perceived learning of basic clinical reasoning skills in self-study/exam preparations (P = 0.032), general hospital grand rounds (P = 0.049), and clinical rounds (P = 0.024 for consultant-led rounds and P = 0.038 for senior peer-led rounds). There were also significant differences in the perceived learning of advanced clinical reasoning skills among peer-led tutorials (P = 0.04), journal clubs (P = 0.006), morning reports (P = 0.002), and on-call duties (P = 0.031).

Conclusions: The trainees showed a significant preference for structured learning environments rather than clinical environments, especially for advanced clinical reasoning skills. Trainees likely struggled with cognitive overload in clinical environments. Local postgraduate psychiatry programs will likely benefit from implementing multiple educational interventions that facilitate teaching and learning clinical reasoning in complex clinical environments.
Jacobsen’s syndrome: case report
Authors: Barycheva L. Yu. , Bachieva L. I. , Koz’mova N. A.
Published: May 2024

Introduction. Jacobsen syndrome (JS) is a rare genetic disease associated with the deletion of chromosome 11q, characterized by multiple malformations, hematological and immune disorders. The development of immunodeficiency in JS is often underestimated, which leads to recurrent infectious complications.

   Presentation of a clinical case. The article presents a clinical case of a patient with a deletion of chromosome 11q and combined immunodeficiency. Our patient had recurrent infections, cytopenic syndrome, combined immunodeficiency, as well as other clinical manifestations of Jacobsen syndrome. In addition to a decrease in serum immunoglobulins, a deep deficiency of the T-cell link of immunity with a low content of T-lymphocytes, recent emigrants from the thymus, has been established.

   Conclusions. The peculiarity of the presented clinical case is that with a relatively small amount of deletion 11q, the child realized a complete clinical phenotype of the disease and a deep combined immunodeficiency. The article was written to improve doctors’ knowledge about this rare form of congenital immunodeficiency.
Diagnostic significance of the determination of antinuclear antibodies in children with autoimmune hepatitis
Authors: Zhuzhula A. A. , Kurbatova O. V. , Petrichuk S. V. , Parakhina D. V. , Snovskaya M. A. , Movsisyan G. B. , Semikina E. L. , Potapov A. S. , Fisenko A. P.
Published: May 2024

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Mern(Mongodb , Express-Js, React-Js, Node-Js) Stack Web-Based Themefied Education Platform For Placement Preparation
Authors: Sahni Varsha , Chopde Atharva , Goswami Mrinmoy , Kumar Ankit
Published: May 2024

This paper examines how webapps can be developed and implemented in a themefied way for education. The MERN stack, which means MongoDB, Express.js, React.js and Node.js is the technology employed to build these modern dynamic web applications through the paper. Themefication has potential to motivate as well as engage students within a learning environment when non-themed situations are incorporated into thematic aspects. Traditional teaching approaches fail to fully captivate learners’ attention, leading to reduced motivation in educational settings as a whole. In particular, computer science and IT students often have this feeling. The problem this research review poses is whether themefication can help address these issues in education background, especially in a college setting. The paper is developed on the basis of creating a platform that will offer an interactive and engaging learning environment around various technologies focusing mainly on placement preparation through different methods. This paper has been informed by data insights from google surveys and other datasets available on previous studies, as well as an extensive literature review of works already existing on the topic. This study aims at finding out if this platform can aid students to improve their attention level while studying thus also have focus using thematic approach which maybe more familiar to them hence encouraging them to keep going. Moreover, it provides valuable details about the technical aspects of the platform i.e., its features, design ideas and underlying technology implemented during this educational development. This survey examines new approaches to creative educational technology and practices for placement readiness based on an examination of survey data, drawing upon prior research insights, and analysis of the codebase behind such system
Regarding digitalization and school geography
Authors:   Sofia University, Vasileva Maya
Published: May 2024

Pervasive digitization in a school context does not simply imply a new way of teaching and learning, it is projected into the learning content and into the lesson. In this sense, what are the prospects for teaching geography? The relationship between digital technologies and geospatial relationships has long been debated, i.e. the new perception of spatial configurations, new spatial practices, new geographical distribution of digital infrastructures. Digitization, by itself, cannot project the development of modern geographical science and geography in the classroom, however, it offers opportunities for a critical approach to basic geographical concepts, to modern diagnostic assumptions in geographical science, to current geographical localizations. In this sense, the article systematizes and presents a critical analysis of the issue, more specifically – outlines the relationship between digitalization and school geography in Bulgaria in several steps: 1) outline the key characteristics of the digital common culture, considering the digital not as technical, but more soon as a social and cultural phenomenon, 2) outlining the relationship between digital and geography, referring to some current models and 3) outlining the projection of this relationship in the normative base and the information-methodological resource of school geography in the Bulgarian school. Based on the analysis, the need for additional and more in-depth studies on the issue is proven.
The Effect Of Management Information System On The Work Effectiveness Of ASN At BPKAD, Bengkulu City
Authors: Apriana Apriana , Siswanto Siswanto , Wijaya Ermy
Published: May 2024

This study aims to determine the effect of management information systems on the work effectiveness of ASN at BPKAD Bengkulu City. The results showed that there was an influence of management information systems on the work effectiveness of ASN BPKAD Bengkulu City, with the test results obtained t count > t table (12.837 > 2.002) with The regression equation Y = 16.84 + 0.53X means that for every 1 unit increase in the value of the management information system variable, the ASN work effectiveness variable will increase by 0.53 at the Bengkulu City BPKAD. The value of the correlation coefficient (r) of 0.63 indicates that there is a strong influence between the management information system on the work effectiveness of ASN BPKAD Bengkulu City because it is in the interval 0.60-0.799. The Coefficient of Determination (KD) value of 40.1% means that the contribution of management information systems to the work effectiveness of ASN BPKAD Bengkulu City is 40.1% and 59.9% is influenced by other variables not examined.
Analysis Of Marketing Strategy At Business Resources Store Bintuhan Kaur Regency
Authors: Afiro Dezandra , Afriani Sulisti , Effendi Yanto
Published: May 2024

Marketing strategy is a form of plan that unravels in the marketing field. To obtain optimal results, this marketing strategy has a broad scope in the field of marketing, including strategies dealing with competition, pricing strategies, product strategies, service strategies and so on. The aim of this research is to determine the marketing strategy at Toko Sumber Bisnis Bintuhan, Kaur Regency. The sample in this study were 30 people consisting of 4 employees at Toko Sumber Bisnis Bintuhan, Kaur Regency for internal factors and 26 people for external factors, namely customers. The analysis method used was SWOT analysis consisting of the Internal Strategy Factor Matrix (IFAS) and the External Strategy Factor Matrix (EFAS). The results showed that the marketing strategy at Toko Sumber Bisnis Bintuhan of Kaur Regency supports the aggressive strategy, or SO strategy in SWOT matrix. The result of the sum of the strengths owned is 43.20 while the weaknesses are 26.90, then the internal quadrant of the factors is 43.20 - 26.90 =16.30 which means the ability of Toko Sumber Bisnis Bintuhan of Kaur Regency to utilize the strengths and minimize the weaknesses that exist on the internal. The chances of this strategy are 42.60 and the threat is 23.41. So the external quadrant factors are 42.60 - 23.41 = 19.19, which means that the high ability of Toko Sumber Bisnis Bintuhan of Kaur Regency to take advantage of opportunities and overcome the threats faced by companies in marketing clothes, bags and shoes.
Marketing Strategy Analysis Of Arco Azka Manna Kitchen Msmes, Bengkulu Selatan
Authors: Arsianti Devi , Hanila Siti , Damarsiwi Eska Prima Monique
Published: May 2024

Pursuant to result of calculation of internal factor and strategy ekternal marketing of UMKM Snack Kitchen of Arco Azka got by co-ordinate value for kuadran analyse internal SWOT score wight ( 5,62) and score wight of eksternal ( 5,77). Pursuant to each calculation of kuadran above indicating that biggest value reside in at SO kuadran that is 6,72. The value obtained from calculation of strength score and opportunity score, where company maximize internal strength which owned  by  an  company  by  exploiting  existing  opportunity.  Kuadran  analyse SWOT applying of strategy marketing of UMKM Snack Kitchen of Arco Azka show its position reside in at I kuadran, that strategy the yielded is strategy of SO, that is organization have the power of and opportunity where organization in a state of settled and prima. Conducive organization to continue to ekspansi, enlarging growth and reach for progress maximally. compatible strategy is (penetration of market and development of market) and product development in this time, is so that diversified by konsentrik can lessen risk related to narrow;tight product lini.
The Role of Marketing Management Through Social Media Instagram on Scarf By Miwa in Aceh Singkil
Authors: Magfira Araza Yudha , Nurbaiti Nurbaiti , Harlina Sella Fauziati
Published: May 2024

Bymiwa scarf is one of the businesses in the field of hijab that is in great demand by the public. scarfbymiwa sells various kinds of headscarves with various motifs, the hallmark of scarfbymiwa is selling various kinds of veils (hijab) with various motifs and made of voal cotton. Knowing the implementation of marketing management in the scarfbymiwa business through Instagram social media (3) Evaluating the scarfbymiwa marketing management through Instagram social media (4) Following up the scarfbymiwa business. The method used is descriptive with a qualitative approach. The subject of this research is Ownerscarfbymiwa, and 30 scarfbymiwa consumers from various circles, the determination of research subjects is done by interviewing respondents. Data was collected using observation techniques, interview techniques and documentation techniques. The results showed that the role of marketing management was very helpful in marketing scarfbymiwa products on Instagram. From the owner who is very good at marketing through Instagram social media, then consumers really appreciate Instagram social media marketing and 30 consumers 9 (90%) like Instagram social media marketing and often use it while 1 respondent (10%) likes but doesn't like it in social media marketing. product photo design is lacking because it is attractive. Therefore, it is necessary to pay more attention to uploading products, to pay more attention to product photo designs.
Comparative Analysis of Marketing Strategies for Online Shopping Applications on Shopee and Lazada (Case Study of Febi Uinsu Students)
Authors: Prasetyo Aris Kukuh , Khalizah Siregar Siti Nur , Nurbaiti Nurbaiti
Published: May 2024

Development in the growing world of business have mande infulencing the world esier. This can be observed in buying goods as desired in a transaction using E-Commerce, regradless of the infulence in the marketing strategy of two E-Commerce. Where in the marketing strategy can be observed in terms of prices, products, promos and service offered. This research method uses qualitative methods based on literature results through sources from previous research results by discussing data based on theory 15 informants. This study aims to determine the E-Commerce application that is in great demand by the respondents in terms of its marketing strategy. The results of this study indicate that the most widely used E-Commerce based on its marketing strategy is shopee. this can be seen in terms of the price offered, the promotions provided, the products sold according to the prcie, and the service provided.
Analysis of Clothing Supply Chain Strategy at Lina Stores
Authors: Sahputri Andriani , Manurung Nadya Maulidya , Aisyah Siti
Published: May 2024

Penelitian ini bertujuan untuk mengetahui strategi rantai pasokan pakaian pada Toko Lina. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data yang digunakan adalah dengan cara penelitian kepustakaan dan wawancara. Hasil penelitian menunjukkan bahwa model manajemen pasokan di industri Toko Pakaian Lina yaitu meliputi dari beberapa pemasok pakaian/kain lainnya. Dan juga Toko Pakaian Lina menggunakan tiga macam aliran dalam suatu proses melakukan rantai pasokan, yaitu Aliran produk, Aliran keuangan dan juga Aliran informasi. Tentunya Toko Pakaian Lina sangat teliti dalam melihat dari pemasok mana yang memiliki jahitan yang terbaik, dan mana juga yang banyak peminatnya dari konsumen. Untuk penentuan harga pakaian pastinya harus sesuai dengan harga pasar yang ada juga pakaian yang diinginkan, karena Toko Pakaian Lina menyediakan pakaian dengan kain tekstil yang beragam dan berkualitas. Aliran keuangan yang mengalir dari beberapa toko pemasok ke Toko Pakaian Lina terjadi karena adanya pembelian suatu barang yang nantinya siap untuk disalurkan kembali di Toko Pakaian Lina menjadi suatu barang jual.
This study aims to determine the strategy of the clothing supply chain at the Lina Store.  This research is a descriptive research with a qualitative approach.  The data collection technique used is by means of library research and interviews. The results showed that the supply management model in the Lina Clothing Store industry includes several other clothing/fabric suppliers.  And also Lina's Clothing Store uses three kinds of flow in a supply chain process, namely Product flow, Financial flow and also Information flow. Of course, Lina's Clothing Store is very careful in seeing which suppliers have the best stitches, and which ones have a lot of demand from consumers.  For determining the price of clothing, of course it must be in accordance with market price, as well as the clothes you want, because Lina's Clothing Store provides clothes with various and quality textile fabrics.  The financial flow that flows from several supply stores to Lina's Clothing Store occurs because of the purchase of an item which is later ready to be distributed back to Lina’s Clothing Store into a sale item.
 Keywords:
Clothing, supply chain management, textile fabrics, performance.
The Effect of Consumer Trust, Emotional Values, Functional Values and Social Values on Iphone Brand Loyalty in Students of Muhammadiyah University of Bengkulu
Authors: Ilahi Sirat Agus Rahmad , Islamuddin Islamuddin
Published: May 2024

A research that has the formulation of the problem How do Consumer Trust, Emotional Values, Functional Values ​​and Social Values affect Iphone Brand Loyalty in Students of Muhammadiyah University of Bengkulu? The purpose of this study is to find out how the effect of consumer trust, emotional values, functional values ​​and social values ​​on iPhone brand loyalty in Students of Muhammadiyah University of Bengkulu. The sampling technique used was the accidental sampling based on predetermined criteria totaling 100 respondents. The data was collected using the observation, documentation and questionnaires. The data that has been processed was analyzed using the SPSS 24 formula.The hypothesis test with t-test obtained t-count > t-table (2.673> 1.699). The Consumer Trust (X1), Emotional Value (X2), Functional Value (X3) and Social Value (X4) ) has an effect on consumer brand loyalty (Y). This can be seen from the hypothesis test Simultaneously. F-table > F-count (12.749 > 1.850). This is evidenced from the correlation analysis R = 0.802 (80.2%) and almost close to 1. The coefficient of determination is R2 = 0.64.4 or about 64.4% while 35.6% is a contribution of other variables not examined
The Influence Of Leadership, Incentives and Work Discipline at PT. Sinar Mutli Sepadan Finance Bengkulu City
Authors: Maldani Dhiki , Subandrio Subandrio
Published: May 2024

This study aims to determine the influence of leadership, incentives and work discipline on employee performance at PT. Sinar Mutli Sepadan Finance Bengkulu City. This type of research is a type of quantitative descriptive research, the object of this research is the employees of PT. Sinar Multi Sepadan Finance Bengkulu City, which is precisely located on Jl. Salak Raya, Bengkulu City, Bengkulu. The sampling method uses a non probability technique, namely accidental sampling. The number of respondents in this study were 160 people. Methods of data collection using a questionnaire. Data analysis techniques using Multiple Linear Regression Analysis Test, and Hypothesis Test, namely t test and f test.
The results of this study can be concluded that the variable Leadership has a positive effect on Employee Performance, Incentives have a positive effect on Employee Performance, Work Discipline has a positive effect on Employee Performance, and Leadership, Incentives and Work Discipline together have a significant effect on Employee Performance at PT. Sinar Mutli Sepadan Finance Bengkulu City.
The Influence of Human Resource Development on Employee Performance at PT. Bukit Angkasa Makmur
Authors: Nando Zery Try , Ratnawili Ratnawili
Published: May 2024

The purpose of this study is was to determine the effect of human resource development on employee performance at PT. Bukit Angkasa Makmur. several factors that will be discussed in this study, including Human Resource Development on Employee Performance at PT. Bukit Angkasa Makmur. The objects in this study are employees of PT. Bukit Angkasa Makmur numbered 174 people. Data collection techniques in research are observation and questionnaires.There are several data analysis techniques used in this study, including descriptive analysis, classic assumption test, simple regression analysis, coefficient of determination (R2) and hypothesis testing. Based on the research results, the following conclusions can be drawn: The results of research on Human Resource Development have a significant influence on Employee Performance at PT. Bukit Angkasa Makmur from the results obtained from the t-test results obtained a tsig value of 0.000 which is smaller than the significant level used, namely 0.05, then Ho is rejected, which means that Human Resource Development has a significant effect on Employee Performance at PT. Bukit Angkasa Makmur.
The Effect of Performance Allowances on Work Motivation and Employee Performance at the Ministry of Religion of Bengkulu City
Authors: Zoniarti Zoniarti , Subhi Ramadan
Published: May 2024

This study aims to analyze the effect of performance allowances on work motivation and employee performance at the Ministry of Religion (Kemenag) of Bengkulu City. this uses quantitative method as an explanatory research approach, the data analysis technique used is multiple regression. The statistical test results show that there is a positive and significant influence between performance allowances and employee work motivation, as well as between performance allowances and employee performance. The analysis also identified several potential problems related to the provision of performance allowances, including unclear criteria, unequal distribution, and delays in payment. To address these issues, it is recommended that performance allowance policies be clear, transparent, and involve employees in program planning and evaluation. The importance of effective and open communication in managing performance benefits is also emphasized. The general benefits of performance allowances, such as high motivation, increased productivity, and improved psychological well-being of employees, were positively highlighted in this study. With the results of calculations using SPSS, it was found that work motivation and performance variables jointly significantly affect employee performance allowances. The test results state the rejection of the null hypothesis, indicating that the higher the value of performance allowance, the higher the work motivation and performance of employees of the Ministry of Religious Affairs of Bengkulu City.
Ombudsman Performance Representative Of Bengkulu Province
Authors: Sapitri Presilia Andra Sari , Saputra Harius Eko , Yusuarsono Yusuarsono
Published: May 2024

This study aims to determine the performance of the Bengkulu Province Representative Ombudsman Institution in examining and resolving public complaints reports from various existing cases. This study uses a qualitative descriptive method. Data collection uses observation, interview and documentation techniques. The informants in this study amounted to 6 people, namely the head of the ombudsman, assistant, administration, and reporting. The results of this study show that the performance of the Bengkulu Province Representative Ombudsman has a good performance, based on Bernardin's theory (2000:34) the researcher found that the Bengkulu Province Representative Ombudsman's performance was good even though in terms of human resources that were still lacking, the Bengkulu Province Representative Ombudsman always carried out his duties. professionally and have high motivation and commitment