bluuebunny/crossref_metadata_2025 huggingface dataset:
Practical Proposals for ‘expression’ of Thinking
Authors:   The Korean Society of Culture and Convergence, Kim Jackyoung
Published: December 2022

First, this thesis examines the case in which the learner draws out his or her latent thoughts through the instructor's open questions. Then, the new students further deepen the ideas raised, and finally explore the possibility of organizing the ideas into an academic writing form. To this end, we introduce open questions, repeated questions, and forced idea methods that allow freshmen to express their thoughts immediately. First, these questionnaires help freshmen come up with ideas and help organize the concepts related to the ideas. Second, it helps freshmen to clearly capture the concepts they are interested in and to set a topic. Third, these questioning methods also play a role in clarifying the meaning of concepts by finding the boundaries of concepts that freshmen use vaguely in their daily life.
A Study of Passive Sentences with Syntactic Transitivity: Focused on Passive Sentences with ‘eul/leul’ Noun Phrase
Authors:   The Korean Society of Culture and Convergence, Kim Youngil
Published: December 2022

The purpose of this paper is to discuss whether passive sentences with 'eul/leul' noun phrase can be treated as transitive sentences. We divided them into two types of passive sentences with 'eul/leul’ noun phrase and examined the grammatical and semantic characteristics to compare each other. After that, we argued that the passive sentences made of a type of 'ppaeasgida' have syntactic transitivity. Sentences belonging to this type indicate the meaning of the removal of the property from its original owner, and the event in which the change of owner occurs as the property moves to the new owner who is called an agent. In addition, we explained that the sentences are transitive constructions, and the predicates are transitive verbs, but they have the characteristics of ditransitive verbs with three core arguments such as ‘give’ and ‘receive’. Through this, we actively acknowledged that passive sentences with an object are no longer treated as an exception in Korean studies, and there are syntactic transitive sentences in passive sentences and transitive verbs in passive verbs as well.
SWOT-AHP Analysis Based China Musical Industry Development Strategy
Authors:   The Korean Society of Culture and Convergence, Wang Ruxin , Ryu SeungWan
Published: December 2022

In this study, in order to find development strategies for musical industry of China, the SWOT method was used to analyse internal and external environment. In addition, the analytical hierarchy process(AHP) was used to fine strategic priority among SWOT based development strategies. As a method of utilizing the research results, when establishing policies and strategies with limited resources such as the government, musical-related organizations, and companies, SWOT-AHP analysis results can be used to easily determine policy priorities.
A Study on the Perception of Service Satisfaction in Gyeongju Major Tourist Spots Using Big Data
Authors:   The Korean Society of Culture and Convergence, Lee Jong Hwa , Kang Sungbae
Published: December 2022

The MZ generation is a hot topic because they play a key role in all consumer industries. The MZ generation also plays an important role in the tourism industry. Especially, sustainable tourism based on experience content discovery and locality is needed. In particular, as the growth of the cafe industry has increased significantly through various community channels, regional-based tourist destinations are being alienated. This study aims to analyze the reviews of major tourist attractions in Gyeongju and prepare supplementary measures to improve the tourism product into MZ generation friendly way. By analyzing the difference between the reputation of tourist attractions and the actual satisfaction of consumers, this study intends to find services that need to be improved in tourist attractions. In addition, supplementary measures for the elements of tourist attraction services are presented using the analysis of the negative meaning of comments.
Development of a Metaverse Course: ‘3D Time Machine’ Using Blender
Authors:   The Korean Society of Culture and Convergence, Choi Wonjae
Published: December 2022

As the metaverse is being discussed as the main educational environment, it is necessary to take this into consideration in the higher education curriculum to create specific subjects that can develop creativity. Accordingly, by producing a lecture that implements the metaverse not only in theory, but also in practice, the students' responses – the possibility of developing practical creativity in the educational field – were examined. This paper introduced a lecture using Blender(3D engine), as an elective course in the history department of the university, and shared insights found in this lecture (especially mini-projects performed with participating students). In addition, the correlation between constructivist activities that implement metaverse environments and creativity development classes is considered through educational theory, which provides an opportunity for peer researchers working in higher education to benchmark lectures that can effectively promote students' creativity.
Review on Digital Technology Convergence Studies for Therapeutic Use of Music
Authors:   The Korean Society of Culture and Convergence, Park Hye Young , Ye Jae Suk
Published: December 2022

The purpose of this study is to understand of cultural arts education in the early childhood education field through big data analysis. As a result of the study, ‘education', 'childcare', 'parent', 'guide', and 'support' etc were found as key keywords. They were related to the subjects of cultural arts education, program contents and methods, notices and applications. Second, as a result of macroscopic analysis, it was found that the density between keywords was high and the centrality was low. As a result of the microscopic analysis, it was found that connection centrality and prestige centrality were higher than the frequency for infants and young children. Third, the ego network for education, infants, parents, and teachers was analyzed. Based on the above results, basic data and implications were provided.
TOWARDS A DISCUSSION ABOUT THE CAUSES OF THE RUSSIAN REVOLUTION AND THE STANDARD OF LIVING IN THE LATE 19TH AND EARLY 20TH CENTURIES
Authors:   Institute of History and Archeology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation, NEFEDOV SERGEY
Published: December 2022

The article is devoted to the discussion between «pessimists» and «optimists» about the causes of the Russian revolution of 1917-1922. «Pessimists» traditionally believe that the main reason for the revolution was the low standard of living of the masses. «Optimists» argue that the economy of the Russian Empire progressed rapidly, and the level of consumption gradually increased. The next stage in this discussion was the book by B. N. Mironov «Russian Modernization and Revolution» published in 2019. In the new book, B.N. Mironov declares the development of Russia an «economic miracle» and cites 12 signs of this «miracle». In 2022, the Sociological History magazine held a round table discussion on Mironov's book and published the author's responses to critical statements made in the same issue. The article is devoted to the analysis of this criticism and the answers of the author of the book. It is shown that Mironov's argumentation is largely based on the use of unreliable yield statistics and an erroneous interpretation of the results of anthropometric measurements.
LES prediction of transitional flows in LP turbine cascades: effects of blade loading, flow phenomena and numerical setup
Authors: Tateishi Atsushi , Tani Naoki , Okamura Yasuhiro , Hamabe Masaaki
Published: December 2022

This paper presents detailed validations of a Large Eddy Simulation (LES) methodology for various transitional phenomena in low pressure turbines. The results are discussed to identify key phenomena to be resolved accurately toward future industrial use of LES. Detailed comparisons between experimental and CFD results are made on three different 2D cascades with different blade loading. One is low-lift and fully laminar design, while the others are moderate- and high-lift designs with boundary layer transition. The experimental data are obtained in a low speed linear cascade at Iwate University. All computations are conducted by a carefully-designed overset LES code. For the high-load design with a distinct laminar separation on the suction side, the LES result shows satisfactory agreement with the test. However, although the peak of total pressure loss distribution is predicted quite accurately, integrated cascade losses are over-predicted in the other two cases. For the laminar blade, the LES result implies some differences can exist in the state of wake, while the transitional blade shows delay of transition in the boundary layer. The effects of inflow turbulence intensity, length scale, and stream tube contraction are discussed in detail to improve LES prediction.
La colección inédita de remedios bizantinos en el códice de Galeno Urb. gr. 67
Authors: Durán Mañas Mónica , Pérez Martín Inmaculada
Published: December 2022

Se presenta en este artículo la primera edición de una breve colección de recetas recogidas en el manuscrito Città del Vaticano, Biblioteca Apostolica Vaticana, Urb. gr. 67, un códice dedicado enteramente a Galeno y compuesto de dos partes bien diferenciadas. En su parte más antigua (ff. 53-275), datable hacia 1300, aparece esta colección de remedios de tradición galénica, que el copista ha añadido (ff. 186v-187v) para completar el cuaderno numerado ??’ (17) al final de la copia de Galeno, De compositione medicamentorum secundum locos.
ENNIUS, SCEN. 82 TrRF
Authors: Kraggerud Egil
Published: December 2022

Cicero’s quotation (at Rep. 1. 30) of Ennius scen. 82 TrRF (= XCV, lines 185-187 Joc.) needs some conjectural surgery to become more intelligible and hopefully a more memorable quote: I propose sint instead of sit; obseruationes instead of obseruationis; ante pedes quod est non spectant instead of quod est ante pedes nemo spectat.
Relación entre la composición corporal y el equilibrio en mujeres mayores
Authors: Corchero-Soriano David , Mendoza-Muñoz María , Rojo-Ramos Jorge , Barrios Fernandez Sabina , Carlos-Vivas Jorge , Pastor-Cisneros Raquel
Published: December 2022

El objetivo de este estudio fue evaluar e identificar las relaciones existentes entre el Índice de Masa Corporal (IMC) y el porcentaje graso, con el equilibrio de mujeres mayores que viven en la Comunidad Autónoma de Extremadura, España. Se realizó un estudio transversal con una muestra de 188 mujeres extremeñas mayores de 55 años. Se evaluó el peso, la talla, el porcentaje graso mediante bioimpedancia y el equilibrio tanto dinámico como estático mediante estabilometría. Se realizó un análisis de regresión para evaluar las relaciones existentes entre estas variables, así como su valor predictivo. Los resultados nos informan de la asociación existente entre las variables porcentaje graso e IMC con el equilibrio dinámico, siendo esta última asociación la más significativa estadísticamente. Para concluir, se puede afirmar que existe una relación inversa entre los índices antropométricos IMC y porcentaje de grasa con el equilibrio dinámico.
Determinación de la auto-eficacia y el disfrute hacia la actividad física de los infantes que asisten al nivel de transición de escuelas en el Valle Central en tiempos de pandemia
Authors: Álvarez Bogantes Carlos , Villalobos Víquez Grettel Pamela , Molina Viales Kimberly , Vargas Villalobos Laura
Published: December 2022

La agudización del sobrepeso y la obesidad en niños de edad escolar en tiempos de pandemia representan un problema de salud pública. Lo que hace necesario que desde edades tempranas sean identificados los determinantes de la actividad física de los pre-escolares, con el fin de poder desarrollar estrategias que contribuyan a mitigar las secuelas de esta pandemia. El objetivo de este estudio fue analizar la auto-eficacia y el disfrute de los estudiantes de 6 años, durante la pandemia en una escuela pública y una privada. Para poder determinar la percepción en las variables del estudio, los participantes completaron las escalas de auto-eficacia y disfrute, ayudados por sus docentes y el personal que formó parte de la investigación. Se utilizó estadística descriptiva, y para determinar si existieron diferencias entre las variables de disfrute y auto-eficacia entre los estudiantes de dos tipos de escuela, se realizaron pruebas comparativas no paramétricas, específicamente la U de Mann-Whitney. No se encontraron diferencias estadísticamente significativas entre escolares de escuelas públicas y privadas, ni entre niños y niñas, en los puntajes globales de disfrute y autoeficacia. En conclusión, se evidenció que no hay diferencias entre los estudiantes de pre-escolar de ambas escuelas, pero sí un deterioro en ambas variables.
Propuesta de unidad didáctica para Educación Física: “la orientación deportiva como herramienta de inclusión para los alumnos con TDAH”
Authors: Hernández-Beltrán Víctor , González-Coto Víctor A. , Gámez-Calvo Luisa , Luna-González Julia , Gamonales José M.
Published: December 2022

En el ámbito educativo, cada vez son más las propuestas de evolución hacia modelos educativos en los cuales se fomente la inclusión con la finalidad de generar un clima positivo por parte de todo el alumnado hacia el proceso de Enseñanza-Aprendizaje, cuyo principal objetivo sea la aceptación de las diferentes dificultades de aprendizaje que fomente la empatía hacia las dificultades de los demás. El alumnado con Trastorno por Déficit de Atención y/o Hiperactividad (TDAH) a menudo encuentra barreras relacionadas con su perfil de inatención y/o hiperactividad que le impiden alcanzar su desarrollo integral en el ámbito educativo. Por ello, la presente propuesta de Unidad Didáctica titulada “Orientación deportiva para personas con TDAH” ofrece posibilidades para dar respuesta a estas dificultades mediante adaptaciones no significativas en el área de Educación Física. La implicación familiar y docente es fundamental en este proceso de enseñanza-aprendizaje, debido a la cantidad de beneficios del ejercicio físico para personas con TDAH. Además, la metodología empleada es la gamificación, pues que permite aumentar la motivación del alumnado debido a basarse en el juego como eje principal de las sesiones, de la misma forma, permite al docente controlar los logros obtenidos por el alumnado. Por ello, la gamificación se aplica a una propuesta de unidad didáctica de orientación deportiva, una práctica de ejercicio físico principalmente aeróbico. Algunos de los beneficios de la práctica de la orientación deportiva en escolares son la ayuda al desarrollo de competencias básicas, reducción del estrés, la ansiedad y la depresión y el aumento del rendimiento académico, además de la reducción de los síntomas de Trastorno por Déficit de Atención y/o Hiperactividad A su vez, permite el desarrollo de valores deportivos, de aceptación e inclusión de los demás y, respeto y cuidado hacia el medio ambiente. Finalmente, es recomendable realizar diferentes propuestas de Unidad Didáctica para otros niveles educativos con la finalidad de favorecer las competencias clave y los valores sociales.
Revealing the dominant factors of vegetation change in global ecosystems
Authors: Zhang Yuxin , Sun Juying , Lu Yafeng , Song Xueqian
Published: December 2022

In the context of climate change, revealing the causes of significant changes in ecosystems will help maintain ecosystem stability and achieve sustainability. However, the dominant influencing factors of different ecosystems in different months on a global scale are not clear. We used Ordinary Least Squares Model and Mann–Kendall test to detect the significant changes (p < 0.05) of ecosystem on a monthly scale from 1981 to 2015. And then multi-source data, residual analysis and partial correlation method was used to distinguish the impact of anthropogenic activities and dominant climate factors. The result showed that: (1) Not all significant green areas in all months were greater than the browning areas. Woodland had a larger greening area than farmland and grassland, except for January, May, and June, and a larger browning area except for September, November, and December. (2) Anthropogenic activities are the leading factors causing significant greening in ecosystems. However, their impact on significant ecosystem browning was not greater than that of climate change on significant ecosystem greening in all months. (3) The main cause of the ecosystem’s significant greening was temperature. Along with temperature, sunshine duration played a major role in the significant greening of the woodland. The main causes of significant farmland greening were precipitation and soil moisture. Temperature was the main factor that dominated the longest month of significant browning of grassland and woodland. Temperature and soil moisture were the main factors that dominated the longest month of significant browning of farmland. Our research reveals ecosystem changes and their dominant factors on a global scale, thereby supporting the sustainable ecosystem management.
Epidemiology and risk factors of nasal carriage of Staphylococcus aureus CC398 in two distinct cohorts in France
Authors: Bouiller Kevin , Zeggay Abdeljalil , Gbaguidi-Haore Houssein , Hocquet Didier , Chirouze Catherine , Bertrand Xavier
Published: December 2022

Background

We aimed to determine the prevalence and factors associated with nasal carriage of Staphylococcus aureus CC398 in the community and among hospitalized patients.

Methods

We conducted a prospective cohort study in a French university hospital and a cross-sectional study in the surrounding region.

Results

From June 2019 to July 2020, 591 healthy blood donors (HBDs) and 647 hospitalized patients (HPs) were included. S. aureus CC398 was more prevalent in HBDs than in HPs (7.3% [5.3–9.7] vs. 3.8% [2.4–5.5], p = 0.006). Among S. aureus nasal carriers, the prevalence of CC398 isolates was 24.6% in HBDs and 18.3% in HPs (p = 0.19). No MRSA belonged to CC398. In multivariate analysis, prior antibiotic intake in the past year (OR 3.11 [1.37–7.06]) and active smoking (OR 3.01 [1.00–9.05]) were associated with S. aureus CC398 nasal carriage in the HBD cohort. A history of neurological disease was associated with nasal carriage (OR = 5.43 [1.21–24.2]), whereas an age between 82 and 90 years (OR 0.11 [0.02–0.54]) and diabetes (OR 0.18 [0.04–0.85]) were protective factors in the HP cohort. Contact with livestock was not a risk factor in either cohort.

Conclusion

The prevalence of MSSA CC398 was higher in the community than hospitalized patients. Factors associated with nasal carriage of MSSA CC398 were primarily related to general preconditions. No environmental sources of exposure were identified.
Robust visual cortex evoked potentials (VEP) in Gnat1 and Gnat2 knockout mice
Authors: Flood Michael D. , Veloz Hannah L. B. , Hattar Samer , Carvalho-de-Souza Joao L.
Published: December 2022

Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin, imparting to themselves the ability to respond to light in the absence of input from rod or cone photoreceptors. Since their discovery ipRGCs have been found to play a significant role in non-image-forming aspects of vision, including circadian photoentrainment, neuroendocrine regulation, and pupillary control. In the past decade it has become increasingly clear that some ipRGCs also contribute directly to pattern-forming vision, the ability to discriminate shapes and objects. However, the degree to which melanopsin-mediated phototransduction, versus that of rods and cones, contributes to this function is still largely unknown. Earlier attempts to quantify this contribution have relied on genetic knockout models that target key phototransductive proteins in rod and cone photoreceptors, ideally to isolate melanopsin-mediated responses. In this study we used the Gnat1–/–; Gnat2cpfl3/cpfl3 mouse model, which have global knockouts for the rod and cone α-transducin proteins. These genetic modifications completely abolish rod and cone photoresponses under light-adapted conditions, locking these cells into a “dark” state. We recorded visually evoked potentials in these animals and found that they still showed robust light responses, albeit with reduced light sensitivity, with similar magnitudes to control mice. These responses had characteristics that were in line with a melanopsin-mediated signal, including delayed kinetics and increased saturability. Additionally, we recorded electroretinograms in a sub-sample of these mice and were unable to find any characteristic waveform related the activation of photoreceptors or second-order retinal neurons, suggesting ipRGCs as the origin of light responses. Our results show a profound ability for melanopsin phototransduction to directly contribute to the primary pattern-forming visual pathway.
Associations of serum carotenoids with the severity of sunburn and the risk of cancer: A cross-sectional analysis of 1999–2018 NHANES data
Authors: Cheng Bin , Wu Xixin , Li Ruina , Tu Jiayuan , Lin Sixian , Zhang Xiangda , Mo Xiaoqiao , Xie Tian
Published: December 2022

Background

Sunburn is a common problem for outdoor workers and casual outdoor walkers. Carotenoids are important elements in normal function of skin tissue and skin metabolism and are critical in the development of some cancers. However, the possible relationships between sunburn sensitivity, carotenoids and the risk of cancers remain unknown.

Objectives

To explore the associations of serum carotenoids with sunburn severity and the risk of cancers.

Methods

A cross-sectional study from the National Health and Nutrition Examination Survey from 1999 to 2018 were conducted. The relationship between sunburn and serum carotenoids, cancers were investigated by unconditional or ordinal logistic regression. Mediation analysis was used to explore the effect of carotenoids on the relationship between sunburn and cancers.

Results

A total of 25,440 US adults from 1999 to 2018 were enrolled in this study. There were significant differences in sex, race and natural hair color between the sunburn and non-sunburn people. The severity of sunburn was significantly associated with serum trans-β-carotene, cis-β-carotene, combined lutein, and vitamin A. The odds ratios of severe reactions were 5.065 (95% CI: 2.266–11.318) in melanoma patients, 5.776 (95% CI: 3.362–9.922) in non-melanoma patients, and 1.880 (95% CI: 1.484–2.380) in non-skin cancers patients. Additionally, serum carotenoids were partially attributable to the effect of sunburn on skin and non-skin cancers.

Conclusion

Sunburn severity was associated with cancers, and severer sunburn was related with higher risk of cancers. Serum carotenoids were also associated with sunburn severity. Moreover, the relationship between sunburn and cancers was mediated by some serum carotenoids.
Ultrasonic misdiagnosis of giant pediatric testicular yolk sac tumor: A case report and literature review
Authors: Wang Zilong , Lu Fuding , Song Changze , Wang Xinkun , Li Naifa , Zhai Jiawen , Jiang Baohong , Yuan Jianpeng , Yang Zheng , Xuan Xujun
Published: December 2022

Background

Yolk sac tumor is the most common malignant nonseminomatous germ-cell tumor in children characterized by elevated level of α-fetoprotein (AFP), accounting for 70%–80% of all cases. However, giant yolk sac tumors that involve the entire testicle may be misdiagnosed by color Doppler ultrasonography as orchitis. Therefore, we described a case of a 2-year-old pediatric patient with a giant testicular yolk sac tumor that was misdiagnosed by ultrasonography as orchitis, in order to evaluate the role of measuring AFP levels in the initial diagnosis to aid in the accuracy of the definitive diagnosis of testicular yolk sac tumor.

Case presentation

A 2-year-old boy received outpatient visits for unintentional swelling of the right scrotum for 7 days. Physical examination showed a rubbery swelling of the right scrotum with rejective touch. Then, the patient underwent perineal color Doppler ultrasonography in outpatient visits. The result showed a right testicle size of 29 mm × 22 mm × 20 mm with heterogeneous echogenicity and abundant blood ﬂow, supporting the initial diagnosis of orchitis. However, the initial surgeon was skeptical of the ultrasonography diagnosis. Thus, the patient was admitted to the Department of Andrology on day 2 for further serological and imaging examination. The serum AFP level on day 3 was 323.77 ng/ml. The results of CT and MRI showed a giant tumor of the right testis (26 mm × 21 mm × 29.6 mm) with multiple lymphoid hyperplasia in the inguinal region bilaterally. The patient received radical orchidectomy without lymph node dissection on day 9. The results of postoperative pathological examination confirmed giant testicular yolk sac tumor (T1N0M0S1, Stage Is) and was positive for AFP and SALL4 in immunohistochemistry staining. The patient received three courses of bleomycin–etoposide–cisplatin chemotherapy in the Department of Pediatrics after multidisciplinary team meeting on postoperative days 14, 37, and 58, respectively. During chemotherapy and follow-up, the patient's AFP and lactate dehydrogenase levels continued to decline, and eventually remained within normal range on postoperative day 84.

Conclusion

Measuring the AFP level was necessary for initial diagnosis and follow-up in pediatric cases of testicular enlargement. Radical orchidectomy combined with postoperative bleomycin–etoposide–cisplatin adjuvant chemotherapy was an effective treatment strategy for pediatric giant testicular yolk sac tumors.
Influence of the focusing characteristics of near-infrared lasers on the maintenance of plasma luminescence
Authors: Zhou Lian , Chen Yi , Guo Xin , Shi Yan , Zhao Tianqi , Zhan Chunlian , Jin Shangzhong
Published: December 2022

The interaction of 980-nm continuous laser radiation with the plasma of a continuous optical discharge in xenon lamps at a pressure of p = 12 atm has been studied. The threshold power and characteristics of the laser required to sustain the xenon plasma became our focus. According to the theory of Gaussian beam propagation, the laser parameters after collimation and focusing are obtained by combining ZEMAX simulation and the actual measurement. The influence of the beam waist ω0, which determines the power density distribution at focus, and the Rayleigh range Z0, which determines the energy concentration range, on the threshold maintenance power is expounded. The results show that there is a threshold power density for the generation of plasma, whose value is about 1,500–2,000 W/mm2, and that the threshold maintenance power of the plasma shows an overall decreasing trend with decreasing ω0. When ω0 is reduced to a higher power density that can easily maintain the thermodynamic equilibrium process of the plasma, the mismatch between Z0 and the plasma size caused by the decrease in Z0 makes the threshold power tend to be stable and increasing.
Full-length transcriptome and metabolite analysis reveal reticuline epimerase-independent pathways for benzylisoquinoline alkaloids biosynthesis in Sinomenium acutum
Authors: Yang Yufan , Sun Ying , Wang Zhaoxin , Yin Maojing , Sun Runze , Xue Lu , Huang Xueshuang , Wang Chunhua , Yan Xiaohui
Published: December 2022

Benzylisoquinoline alkaloids (BIAs) are a large family of plant natural products with important pharmaceutical applications. Sinomenium acutum is a medicinal plant from the Menispermaceae family and has been used to treat rheumatoid arthritis for hundreds of years. Sinomenium acutum contains more than 50 BIAs, and sinomenine is a representative BIA from this plant. Sinomenine was found to have preventive and curative effects on opioid dependence. Despite the broad applications of S. acutum, investigation on the biosynthetic pathways of BIAs from S. acutum is limited. In this study, we comprehensively analyzed the transcriptome data and BIAs in the root, stem, leaf, and seed of S. acutum. Metabolic analysis showed a noticeable difference in BIA contents in different tissues. Based on the study of the full-length transcriptome, differentially expressed genes, and weighted gene co-expression network, we proposed the biosynthetic pathways for a few BIAs from S. acutum, such as sinomenine, magnoflorine, and tetrahydropalmatine, and screened candidate genes involved in these biosynthesis processes. Notably, the reticuline epimerase (REPI/STORR), which converts (S)-reticuline to (R)-reticuline and plays an essential role in morphine and codeine biosynthesis, was not found in the transcriptome data of S. acutum. Our results shed light on the biogenesis of the BIAs in S. acutum and may pave the way for the future development of this important medicinal plant.
How many captains for a ship on electoral drift? Limiting the number of leadership candidates in the Flemish Christian-democratic party (CD&V)
Authors: Luypaert Jasmien , Lingier Leen , Bouteca Nicolas , Vandeleene Audrey , Wauters Bram
Published: December 2022

Many Western parties have opened up the process of leadership selection to party members under the noble premises to democratize the party. Yet, this might just be window-dressing as party leadership selection is often a coronation rather than an open contest. We argue that the preparation phase preceding the actual election phase is crucial in understanding the balance between the impact of party members and the steering of the party elite. This study compares the preparation phase of two leadership contests after losing elections in one party, the Flemish Christian-democratic party in Belgium: one with a single candidate and one with an exceptionally high number of candidates. Our analysis, based on 22 in-depth elite interviews, demonstrates that leadership elections are influenced by a cluster of different influencing actors, but in particular by what we label the “last person standing” whose candidacy is identified as the most effective mechanism to influence the nomination process. Other (slightly less effective) influencing mechanisms include encouragements, discouragements and the diffusion of an ideal profile for the future party leader.
Relationship between knee joint discomfort, self-management behavior, and quality of life in the middle-aged and elderly people in China: A cross-sectional study
Authors: Su Manman , Zhou Yang , Zhao Peipei , Zeng Biyun , Zhou Qidi
Published: December 2022

Background

The aim of this study was to describe the knee joint discomfort, self-management behavior, and quality of life (QoL) in the middle-aged and elderly people in China and to clarify the relationship between the knee joint discomfort, self-management behavior, and QoL.

Methods

It is a cross-sectional study and in this study, a stratified multistage random sampling method was used to collect data on the three factors such as knee joint discomfort, self-management behavior, and QoL among the middle-aged and elderly people in the Hunan Province. Spearman's correlation analysis was used to test the relationship between the knee joint discomfort, self-management behavior, and QoL.

Results

The results of the present study showed that among them, the prevalence of knee pain was the highest (52.1%), followed by knee weakness (42.5%), numbness (41.8%), cold feeling (40.0%), tenderness (38.3%), and distension feeling (37.5%). Average score of self-management of knee joint discomfort in the middle-aged and elderly people was 2.14 ± 0.67. The level of self-management in each dimension ranged from high to low as emotional management, daily management, symptoms management, and information management. The average scores of physical component summary (PCS) and mental component summary (MCS) were 42.85 ± 5.34 and 43.62 ± 8.43, respectively. The occurrence, frequency, and severity of discomfort symptoms were positively correlated with the symptoms management, daily management, information management, and self-management behaviors, and negatively correlated with the emotional management, PCS and MSC, except for the occurrence of discomfort symptoms (P < 0.05).

Conclusion

Knee joint discomfort was prevalent in the middle-aged and elderly people. In addition, they displayed a low level of self-management behavior and poor QoL. The middle-aged and elderly people faced knee discomfort symptoms, the more frequent and severe symptoms, the higher level of symptom management, daily management, and information management, and the lower level of emotional management and QoL.
A sentiment analysis approach to the prediction of market volatility
Authors: Deveikyte Justina , Geman Helyette , Piccari Carlo , Provetti Alessandro
Published: December 2022

Prediction and quantification of future volatility and returns play an important role in financial modeling, both in portfolio optimisation and risk management. Natural language processing today allows one to process news and social media comments to detect signals of investors' confidence. We have explored the relationship between sentiment extracted from financial news and tweets and FTSE100 movements. We investigated the strength of the correlation between sentiment measures on a given day and market volatility and returns observed the next day. We found that there is evidence of correlation between sentiment and stock market movements. Moreover, the sentiment captured from news headlines could be used as a signal to predict market returns; we also found that the same does not apply for volatility. However, for the sentiment found in Twitter comments we obtained, in a surprising finding, a correlation coefficient of –0.7 (p < 0.05), which indicates a strong negative correlation between negative sentiment captured from the tweets on a given day and the volatility observed the next day. It is important to keep in mind that stock volatility rises greatly when the market collapses but not symmetrically so when it goes up (the so-called leverage effect). We developed an accurate classifier for the prediction of market volatility in response to the arrival of new information by deploying topic modeling, based on Latent Dirichlet Allocation, in order to extract feature vectors from a collection of tweets and financial news. The obtained features were used as additional input to the classifier. Thanks to the combination of sentiment and topic modeling even on modest (essentially personal) architecture our classifier achieved a directional prediction accuracy for volatility of 63%.
Preserved visuoconstruction in patients with Alzheimer's pathology and anti-neural autoantibodies: A case control study
Authors: Hansen Niels , Hirschel Sina , Teegen Bianca , Wiltfang Jens , Malchow Berend
Published: December 2022

Background

Alzheimer's disease (AD) is seldom reported to be associated with neural autoantibodies apart from those involved in axonal neurodegeneration and amyloidopathy in prior studies. Nevertheless, this is an under-investigated aspect of AD. As we do not know whether additional screening for autoantibodies in AD patients has additional diagnostic and therapeutic value, this study aims to shed light on whether visuoconstructive or figural memory capacities might distinguish these patient populations.

Methods

In this pilot case series, we investigated eight patients suffering from cognitive impairment associated with cerebrospinal fluid (CSF)-based Alzheimer pathology (AP) and with verified anti-neural autoantibodies (AP Aab+) compared to eight AD patients presenting no autoantibodies (Aab–) (AD Aab–). Patients files were reviewed retrospectively regarding their neuropsychological profile assessed via the CERAD (Consortium to Establish a Registry for Alzheimer's Disease) test battery and psychopathology measured by the AMDP (Manual for the Assessment and Documentation of Psychopathology in Psychiatry) system. We also relied on diagnostic parameters as in the CSF and magnetic resonance images.

Results

All patients shared the same pattern of dysfunctional word-list learning and word-list recall resembling a hippocampus-dependent memory dysfunction. Furthermore, both patient groups revealed a CSF profile concurring with Alzheimer's disease. However, visuoconstructive capacity, but not figure recall was preserved in AP Aab+ patients, but not in AD Ab-patients with the shared hippocampus-based memory dysfunction. We observed no relevant differences between the AP Aab+ and AD Aab– groups in CSF cell-counts or intrathecal IgG synthesis. The relative frequency of hippocampal and focal atrophy did not differ either between AP Aab+ and AD Aab– groups.

Discussion

Our pilot findings are encouraging us to conduct large-scale studies to replicate our discovery of preserved visuoconstruction in AP Aab+ patients with hippocampus-based memory dysfunction. The role of anti-neural autoantibodies is still not fully understood. The detection of these autoantibodies might imply another disease pathology that could be either neuroprotective or be affecting other brain regions, i.e., less pronounced disease activity in the right temporo-parietal regions mainly involved in visuoconstruction.
Medicinal Chemistry of Anti-HIV-1 Latency Chemotherapeutics: Biotargets, Binding Modes and Structure-Activity Relationship Investigation
Authors: Wang Yan-Kai , Wei Long , Hu Wei , Yu Pei-Xia , Li Zhong , Yu Hai-Peng , Li Xun
Published: December 2022

The existence of latent viral reservoirs (LVRs), also called latent cells, has long been an acknowledged stubborn hurdle for effective treatment of HIV-1/AIDS. This stable and heterogeneous reservoir, which mainly exists in resting memory CD4+ T cells, is not only resistant to highly active antiretroviral therapy (HAART) but cannot be detected by the immune system, leading to rapid drug resistance and viral rebound once antiviral treatment is interrupted. Accordingly, various functional cure strategies have been proposed to combat this barrier, among which one of the widely accepted and utilized protocols is the so-called ‘shock-and-kill’ regimen. The protocol begins with latency-reversing agents (LRAs), either alone or in combination, to reactivate the latent HIV-1 proviruses, then eliminates them by viral cytopathic mechanisms (e.g., currently available antiviral drugs) or by the immune killing function of the immune system (e.g., NK and CD8+ T cells). In this review, we focuse on the currently explored small molecular LRAs, with emphasis on their mechanism-directed drug targets, binding modes and structure-relationship activity (SAR) profiles, aiming to provide safer and more effective remedies for treating HIV-1 infection.
Identification of Novel Parishin Compounds from the Twig of Maclura tricuspidata and Comparative Analysis of Parishin Derivatives in Different Parts
Authors: Kim Dae-Woon , Kim Jong-Kuk , Gebru Yoseph Asmelash , Kim Young-Hoi , Choi Han-Seok , Kim Myung-Kon
Published: December 2022

Parishin compounds are rare polyphenolic glucosides mainly found in the rhizome of the traditional Chinese medicinal plant, Gastrodia elata. These constituents are reported to have several biological and pharmacological activities. In the present study, two novel parishin derivatives not previously reported as plant-based phytochemicals were identified from a twig of Maclura tricuspidata (MT) and two new compounds were elucidated as 1-(4-(β-d-glucopyranosyloxy)benzyl)-3-hydroxy-3-methylpentane-1,5-dioate (named macluraparishin E) and 1,3-bis(4-(β-d-glucopyranosyloxy)benzyl)-3-hydroxy-3-methylpentane- 1,5-dioate (macluraparishin C), based on the experimental data obtained by UV–Visible (UV–Vis) spectroscopy, high performance liquid chromatography–quadrupole time-of-flight mass spectrometry (HPLC-QTOF-MS) and nuclear magnetic resonance (NMR) spectroscopy. Additionally, gastrodin, parishin A and parishin B were positively identified by spectroscopic evidence and the comparison of HPLC retention time with the corresponding authentic standards. Gastrodin, parishin A and parishin B, macluraparishin E and macluraparishin C were found to be the most abundant constituents in the MT twig. The compositions and contents of these constituents were found to vary depending on the different parts of the MT plant. In particular, the contents of parishin A, parishin B, macluraparishin C and macluraparishin E were higher in the twig, bark and root than in the leaves, xylem and fruit.
Cholera: a modern view on the problem
Authors:   Infectious Diseases Hospital No. 4, Ufa, Korobkо Y. I.
Published: December 2022

Cholera is an acute anthroponotic intestinal infection caused by the bacterium Vibrio cholerae. It is characterized by a fecal-oral route of transmission, damage to the small intestine, watery diarrhea, vomiting, and rapid loss of fluid and electrolytes by the body with the development of varying degrees of dehydration up to hypovolemic shock and death. It is one of highly infectious diseases. It usually spreads in the form of epidemics. Endemic foci are located in Africa, South America, India, and Southeast Asia.
January 10th is Houseplant Appreciation Day
Authors:   SBHI RR Kerch City Children's Hospital, Rybachok O. A.
Published: December 2022

Which month of the year is richest for holidays and celebrations? It’s January, of course, you will easily answer, and you will be absolutely right. The New Year holidays usually last more than a week, we spend a lot of time with family and friends, and the most active people do not imagine themselves caged up at home and enjoy communion with nature. But January is not rich in professional medical holidays, probably because cheerful vacationing people prefer not to get sick these days. It was all the more interesting to learn that on January 10, it is customary in the world to celebrate an unusual date - Houseplant Appreciation Day. This holiday was approved at the initiative of the Gardener's Network, which gave an official opportunity to remind people of the benefits of indoor plants around us. As it turns out, small representatives of the flora not only please the eye with their beauty, but also help in the treatment of various diseases.
Problems of application of fair value in financial accounting
Authors:   Federal State Autonomous Educational Institution of Higher Education “Lobachevsky State University of Nizhny Novgorod”, Nizhny Novgorod, Russia, Druzhilovskaya T.Y.
Published: December 2022

New FSBU (FSBU 25/2018, FSBU 5/2019, FSBU 6/2020, FSBU 26/2020 and FSBU 14/2022) for Russian commercial organizations (including healthcare organizations) introduce the use of fair value in domestic accounting cost. This assessment will have to be applied in a number of situations to account for leases, fixed assets, inventories, capital investments, intangible assets. At the same time, there is no standard in the system of Russian accounting standards that deals with the assessment of fair value. In this regard, the accounting standards mentioned above refer the user to the direct use of international standards containing regulations on the application of fair value. With the exception of FSBU 25/2018 “Lease Accounting”, which refers to IFRS 16 “Leases” and other international financial reporting standards, the rest of the new FSBU indicate the need to apply in Russian accounting to determine the fair value -sti of the international standard IFRS (IFRS) 13 “Fair Value Measurement”. This determines the relevance of studying the problems of using fair value in Russian accounting and using IFRS 13 regulations to determine its value. The results of the study complement the study of the problems of using fair value to evaluate accounting objects. The research methods were comparison, analysis, synthesis, grouping method, systemic and logical approaches. As a result of the research, the areas of application of fair value for accounting for lease transactions, inventory valuation, capital investments, fixed assets and intangible assets are systematized, scientific points of view on the assessment of objects at fair value are summarized. The results of the study reveal positive and problematic aspects of the application of IFRS 13 regulations and contain proposals for solving problematic issues of determining the fair value in Russian financial accounting.
Analysis of factors affecting the quality of beer
Authors:   Department of Chemistry and Ecotoxicology of the Russian Biotechnological University, Roeva N.N. , Koltsova E.G. ,   Department of Chemistry and Ecotoxicology of the Russian Biotechnological University, Chernobrovina A.G. ,   Department of Chemistry and Ecotoxicology of the Russian Biotechnological University, Kulikova N.E. ,   Department of Chemistry and Ecotoxicology of the Russian Biotechnological University
Published: December 2022

The article presents an analysis of the factors affecting the quality of beer. Particular attention is paid to the issues of its colloidal stability, fermentation processes, composition and quality indicators of raw materials. The role of various ingredients influencing the quality of beer is analyzed.
Quantitative assessment of copper content in balms
Authors:   Department of Chemistry and Ecotoxicology of the Russian Biotechnological University, Roeva N.N. , Koltsova E.G. ,   Department of Chemistry and Ecotoxicology of the Russian Biotechnological University, Zaitseva I.A. ,   Department of Chemistry and Ecotoxicology of the Russian Biotechnological University
Published: December 2022

The article presents the results of quantitative assessment of the content of inorganic and organic forms of copper in balms. A differentiated separation of these forms has been carried out on the basis of a developed scheme involving filtration, extraction, reextraction and oxidation. The predominance of non-organocomplexes of copper in the studied balms was noted. The atomic absorption method with flame-free atomization was used as the basic method of analysis. It was found that the total gross content of copper in the studied samples does not exceed its maximum permissible concentrations.
What domestic technological products will allow for import substitution in the IT sphere?
Authors:   SiSoft Group of Companies, Vorobyov S.P.
Published: December 2022

Experts are sure that the withdrawal of foreign leaders of the IT industry from the Russian market will entail certain difficulties. However, even today, domestic developers are ready to offer a high-quality alternative to foreign programs: VCS and digital platforms, web analytics, solutions for industrial design and construction. Russian products will overcome technological limitations and completely replace foreign analogues.
“Smart Warehouse”: new technologies for warehouse logistics automation
Authors:   “Sitek”, Yusupov Rustam , Umetbayev Ruslan ,   Inventory Management and Warehouse Logistics Automation Group at IBS
Published: December 2022

The article discusses the main trends and examples of the implementation of warehouse logistics automation technologies. The authors note that the introduction of the “smart warehouse” system, warehouse robotization multiply increase the speed of order processing and inventory turnover.