bluuebunny/crossref_metadata_2025 huggingface dataset:
Profiling the natural product-likeness of Latin American compound libraries
Authors: Gómez-García Alejandro , Prinz Ann-Kathrin , Acuña Jiménez Daniel A. , Zamora William J. , Barazorda-Ccahuana Haruna L. , Chávez-Fumagalli Miguel Á. , Valli Marilia , Andricopulo Adriano D. , Bolzani Vanderlan da S. , Olmedo Dionisio A. , Solís Pablo N. , Núñez Marvin J. , Rodríguez Pérez Johny R. , Valencia Sánchez Hoover A. , Cortés Hernández Héctor F. , Mosquera Martinez Oscar M. , Koch Oliver , Medina-Franco José L.
Published: February 2024

Compound databases of natural products play a crucial role in drug discovery and development projects and have implications in other areas, such as food chemical research, ecology and metabolomics. Recently, we put together the first version of the Latin American Natural Product database (LANaPDB) as a collective effort of researchers from six countries to ensemble a public and representative library of natural products in a geographical region with a large biodiversity. The present work aims to conduct a comparative and extensive profiling of the natural product-likeness of a recently updated version of LANaPDB and the individual ten compound databases that form part of LANaPDB. The natural product-likeness profile of the Latin American compound databases is contrasted with the profile of other major natural product databases in the public domain and a set of small-molecule drugs approved for clinical use. As part of the extensive characterization, we employed several chemoinformatics metrics of natural product likeness. The results of this study will capture the attention of the global community engaged in natural product databases, not only in Latin America but across the world.
Globalisation and current employment situation in South Africa: An exploratory enquiry
Authors: Mpabanga Zanele L. , Knight Xavier , Ukpere Wilfred , Adekanmbi Foluso
Published: February 2024

Globalisation is a broad concept that has continuously impacted various aspects of human endeavours. Globalisation has influenced the realignment of business strategies as well as impacted the availability of jobs in many countries. In modern organisations, managers must understand how current globalisation impacts employment situations. Since the dawn of contemporary globalisation in the early 1990s, several path breaking advances have emerged. These advances have also impacted the ways works are coordinated in the workplace. For instance, recently the use of independent contractors has increased as opposed to permanent appointed employees. As a matter of fact, globalisation has impacted employment situations in several ways.  Hence, the current paper is an attempt to explore how globalisation has impacted employment situations in South Africa. The main finding of the paper revealed that there is a rising trend in job insecurity in most organisations owing to advanced sophisticated technologies and the utilisation of more atypical employment pattern in the form of casualisation.
ASSESSMENT OF THE COVID-19 PANDEMIC IN SOUTH AFRICA:
Authors: Mandlazi Mario , Nyasha Sheilla
Published: February 2024

The conventional understanding is that the coronavirus pandemic (Covid-19) has challenged the development of the economies at all levels – global, regional and domestic. The need to assess its damage to the South African economy became imperative if the economy has to be resuscitated in an informed and targeted way.  The study therefore aimed at assessing the impact of the Covid-19 Pandemic in South Africa, assessing the effectiveness of the South African government response to Covid-19 and outlining government strategies that have been employed in an effort to rebuild the South African economy. The study utilised the qualitative research approach in which semi-structured interviews were used to collect information on a purposive sample of 12 participants. Through the use of thematic analysis as the data analysis method, the study discovered that the Covid-19 pandemic has both long-term and short-term impacts on the South African economy such as loss of employment, contracting GDP, depressed growth below pre-pandemic projections and lack of organisational performance. In response to Covid-19, the government introduced supporting programmes to businesses, regulations aimed at allowing credit facilities and partnership with various stakeholders. Strategies such as expansionary monetary strategies and the introduction of specific programmes targeting the resuscitation of key economic sectors have been implemented to rebuild the economy. The study, therefore, recommends that the government needs to build a buffer of resources in preparation of devastating pandemics such as Civid-19, such that when the country is hit by the pandemic, there are avenues that can be explored to resuscitate the economy. There is also need to ensure that there is a platform where business organisations can flourish as they can access capital and resources.
ADAM19 cleaves the PTH receptor and associates with brachydactyly type E
Authors: Aydin Atakan , Klenk Christoph , Nemec Katarina , Işbilir Ali , Martin Lisa M , Zauber Henrik , Rrustemi Trendelina , Toka Hakan R , Schuster Herbert , Gong Maolian , Stricker Sigmar , Bock Andreas , Bähring Sylvia , Selbach Matthias , Lohse Martin J , Luft Friedrich C
Published: February 2024

Brachydactyly type E (BDE), shortened metacarpals, metatarsals, cone-shaped epiphyses, and short stature commonly occurs as a sole phenotype. Parathyroid hormone-like protein (PTHrP) has been shown to be responsible in all forms to date, either directly or indirectly. We used linkage and then whole genome sequencing in a small pedigree, to elucidate BDE and identified a truncated disintegrin-and-metalloproteinase-19 (ADAM19) allele in all affected family members, but not in nonaffected persons. Since we had shown earlier that the extracellular domain of the parathyroid hormone receptor (PTHR1) is subject to an unidentified metalloproteinase cleavage, we tested the hypothesis that ADAM19 is a sheddase for PTHR1. WT ADAM19 cleaved PTHR1, while mutated ADAM-19 did not. We mapped the cleavage site that we verified with mass spectrometry between amino acids 64–65. ADAM-19 cleavage increased Gqand decreased Gsactivation. Moreover, perturbed PTHR1 cleavage by ADAM19 increased ß-arrestin2 recruitment, while cAMP accumulation was not altered. We suggest that ADAM19 serves as a regulatory element for PTHR1 and could be responsible for BDE. This sheddase may affect other PTHrP or PTH-related functions.
Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model mice
Authors: Higashiyama Mizuki , Haniuda Kei , Nihei Yoshihito , Kazuno Saiko , Kikkawa Mika , Miura Yoshiki , Suzuki Yusuke , Kitamura Daisuke
Published: February 2024

IgA nephropathy (IgAN) is caused by deposition of IgA in the glomerular mesangium. The mechanism of selective deposition and production of IgA is unclear; however, we recently identified the involvement of IgA autoantibodies. Here, we show that CBX3 is another self-antigen for IgA in gddY mice, a spontaneous IgAN model, and in IgAN patients. A recombinant antibody derived from gddY mice bound to CBX3 expressed on the mesangial cell surface in vitro and to glomeruli in vivo. An elemental diet and antibiotic treatment decreased the levels of autoantibodies and IgAN symptoms in gddY mice. Serum IgA and the recombinant antibody from gddY mice also bound to oral bacteria of the mice and binding was competed with CBX3. One species of oral bacteria was markedly decreased in elemental diet-fed gddY mice and induced anti-CBX3 antibody in normal mice upon immunization. These data suggest that particular oral bacteria generate immune responses to produce IgA that cross-reacts with mesangial cells to initiate IgAN.
Chronicle
Authors: Roth Herbert
Published: February 2024

Chronicle for November 1988 to February 1989
Validasi LKPD Konsep Energi Berorientasi ESD dengan Pendekatan Pembelajaran Berdiferensiasi
Authors: Wahyuni Sri , Khoiri Nur , Novita Mega
Published: February 2024

Pendidikan berkelanjutan yang sering disebut Education for Sustainable Development (ESD) telah menjadi prioritas dalam mempersiapkan peserta didik menghadapi tantangan lingkungan dan energi di abad ke-21. Konsep energi memegang peranan kunci dalam memahami isu-isu berkelanjutan, seperti sumber daya energi terbarukan dan efisiensi energi. Namun, pengajaran konsep energi seringkali terbatas pada pendekatan konvensional yang tidak selalu relevan dengan isu-isu ESD. Penelitian ini bertujuan mengembangkan Lembar Kerja Peserta Didik yang kemudian disebut LKPD berorientasi ESD dengan pendekatan pembelajaran berdiferensiasi. Penelitian mengikuti kerangka ADDIE yang difokuskan pada tahap pengembangan. Hasil analisis bahan ajar menunjukkan kekurangan konsep ESD dalam bahan ajar yang digunakan, terutama di wilayah Rembang yang heterogen. Penelitian menyoroti kebutuhan mendesak untuk mengembangkan LKPD yang mengintegrasikan prinsip-prinsip ESD dan menerapkan pendekatan pembelajaran yang berbeda sesuai dengan tingkat pemahaman dan gaya belajar peserta didik. Hasil penelitian mencakup pengembangan LKPD yang memiliki tujuan yang jelas, mencakup identifikasi bentuk energi, deskripsi transformasi energi, serta pemahaman sumber-sumber energi dan dampak energi dalam kehidupan sehari-hari. LKPD ini juga dirancang untuk memungkinkan peserta didik memprediksi masalah energi dan menganalisis pemecahan masalah dalam pemenuhan kebutuhan energi. Kesimpulan penelitian ini adalah LKPD yang dikembangkan merupakan alat pembelajaran yang komprehensif, relevan, dan efektif dalam mendukung pemahaman konsep energi dengan fokus pada aspek-aspek ESD dengan pembelajaran berdiferensiasi
MEN IN THE WOMEN’S PROFESSIONAL FIELD (USING THE EXAMPLE OF KINDERGARTEN TEACHERS)
Authors:   Russian State University for the Humanities, Kolosova Elena A. , Mayorova-Shcheglova Svetlana N. ,   Moscow State Psychological and Pedagogical University
Published: February 2024

The article presents reflections on the place of men in the women’s professional field on the materials of foreign studies, as well as new data obtained during the study of educators of preschool organizations initiated by sociologists – members of the Research Committee “Sociologists of Childhood” of the Russian Academy of Sciences. It presents the data on the transformation of ideas about male educators in the assessments of the preschool children parents. Information is provided on how male educators deem their social status and what they see as their tasks in the process of educating the younger generation.
INTERPRETATION OF MECHANISMS OF LIFE CREATION IN THE RUSSIAN THEATER OF THE 21ST CENTURY
Authors:   Russian State University for the Humanities, Salimova Leila F.
Published: February 2024

The article critically analyzes a number of performances, the dramaturgical material for which is biographies, documentary texts presented in compilation with artistic, theoretical and philosophical works. The plays are conceptualized as stage interpretations of the life-creative programs of Vladimir Odoevsky, Leo Tolstoy and Konstantin Tsiolkovsky. The author also asks the question about the application by contemporary theatre-makers of the tools of mystification, mythologization and demythologization in the projection of performative comprehension of the text of human life. It is shown that the director with the help of this toolkit and by means of theater not only popularizes, but also creates a new cultural myth or debunks archaic notions about a major historical figure, detecting the points of intersection with the contemporary culture of estrangement. In such directorial decisions the staged biopics begin to sound like a total spectacle about the tragedy of life creation and its Mephistophelean and creative principles.
NARRATIVE THEOLOGY OF E. JUNGEL AND THE PHILOSOPHY OF THE NAME OF A.F. LOSEV
Authors:   Russian State University for the Humanities, Pylaev Maksim A. ,   St. Tikhon’s Orthodox University
Published: February 2024

The article is concerned with an attempt to correlate the thinking of being and faith of Revelation in modern German evangelical theology and in Russian religious philosophy on the example of the work of E. Jungel and A.F. Losev. The author reveals the uniqueness of Jungel’s concept of the Word of God in comparison with the event nature of the Word of God by K. Barth. Jüngel’s narrative theory of the Gospel parable is comprehended in the article in the perspective of finding common ground and especially with the philosophy of symbolic reality, of the name by A. Losev. Jungel thinks through the event nature of Revelation as the Word of God proposed by K. Barth, using the fundamental ontology of M. Heidegger, He develops a theological hermeneutic ontology in which the event of the Word of God acquires the features of the Gospel narrative of the parable. As discursive theology, based on the idea of the metaphysical absolute, is destroyed from the German thinker’s point of view, narrative theology wins its positions. For the German theologian, the core of the Christian kerygma – the death of God – is organically linked to the tradition of nineteenth-century philosophical atheism and is revealed in it no less than in theology and religious philosophy. The Russian philosopher refers to Hegel’s dialectics and Husserl’s phenomenology in understanding the event of God’s Revelation. However, he tries to integrate them into the model of Neoplatonic metaphysics, from which, in his opinion, they were formed. Losev, to the extent that he is a metaphysician, proceeds in the concept of name, unlike Jungel, from the principle of the analogy of being rather than the analogy of belief. The name for the Russian philosopher is not a story, but an energy (force) that has an ontological nature. With him, the name reflects essence rather than describing an event. Losev goes back to Antiquity to reanimate Neoplatonic metaphysics by means of the concept of the symbol, burying in it Plato and the non-metaphysical forms of thinking of the Christian kerygma. Jungel’s theology funds the word-centrism of the Protestant cult and contributes to the explication of the new-modern image of Christianity in Protestantism. Losev, for his part, does not undertake to explicate beyond metaphysics the antique-medieval mystery nature of the Christian cult in Orthodoxy. He needs to convey in his philosophical and theological thought not only the verbal aspect of the event of Revelation. In order to express the aesthetic and mystical dimension of Revelation, the Russian philosopher engages the metaphysics of all-encompassing unity with the idea of an unchanging Absolute
Estratégias de cocriação para um planejamento pertinente na Educação Básica
Authors: Zwierewicz Marlene , Lima Andressa de Fatima Rodrigues dos Santos , Weiss Lilian Patricia Vetterlein , Holz Verónica Violant
Published: February 2024

Este estudo tem como objetivo mapear estratégias de cocriação de planejamentos pertinentes na Educação Básica identificadas em pesquisas vinculadas a um mestrado profissional. Para a análise de 18 dissertações, cuja condição convergente é o uso da metodologia dos Projetos Criativos Ecoformadores (PCE), optou-se pela pesquisa bibliográfica e pela abordagem qualitativa. Nos resultados, identificaram-se como exemplos de estratégias: a vinculação do planejamento às realidades local e global; a participação da comunidade externa na elaboração e no desenvolvimento do planejamento; e a formação docente como um movimento de reflexão e de cocriação de um planejamento polinizador.
TEXTOS COMO DADOS: INTRODUÇÃO À ANÁLISE AUTOMATIZADA DE CONTEÚDO EM PESQUISAS QUALITATIVAS
Authors: Mesquita Murilo
Published: February 2024

Como utilizar ferramentas computacionais, como um software, na pesquisa qualitativa? A busca por responder essa pergunta se dá em meio a noção, por vezes equivocada, de que pesquisas qualitativas não reivindicam um maior refinamento metodológico. Sendo assim, a partir dessa pergunta, a pesquisa busca auxiliar no avanço metodológico de desenhos de pesquisas qualitativos para o campo de estudo de Relações Internacionais. Destarte, tem como objetivo geral apresentar uma ferramenta de pesquisa pautada em técnicas de Análise Automatizada de Conteúdo (AAC), em que pese desenvolver os seguintes objetivos específicos: (i) explicar o que é a Análise de Conteúdo; (ii) identificar as características pertinentes à AAC; e (iii) introduzir o software IRAMUTEQ junto à pesquisa qualitativa do campo de Relações Internacionais. O trabalho possui uma característica didático-pedagógica porque introduz um software para a produção de pesquisa qualitativa. Ao fim estima contribuir para introdução de uma ferramenta que possa auxiliar o refinamento metodológico dentro do mundo da pesquisa qualitativa em Relações Internacionais.
FOREIGN TRADE AND INTERNATIONAL RELATIONS: MERCOSUR, THE EUROPEAN UNION, AND THE VIABILITY OF THE FREE TRADE AGREEMENT
Authors: Lacerda Jan Marcel de Almeida Freitas , Ludwig Fernando José
Published: February 2024

Este artigo busca analisar a relação entre os Processos de Integração Regional (PIR) e o Comércio Exterior (COMEX), principalmente através da atuação do Mercado Comum do Sul (MERCOSUL) e da União Europeia (UE) nas relações comerciais ao redor do mundo. Para tanto, observa-se a ação do MERCOSUL e da UE nas relações comerciais intra e extrabloco, o que propicia a negociação e conclusão de um acordo de livre-comércio entre esses blocos regionais. Assim, a existência recente desse acordo foi uma das motivações para análise dos processos de integração regional e das suas interações mais próximas para a melhoria das relações de comércio exterior. Para isso, propõe a adoção do método de abordagem dedutivo para examinar as RI e COMEX, restringindo a reflexão para o MERCOSUL, a UE e seu acordo de livre-comércio. Utilizou-se também técnicas de pesquisa quanti e qualitativas, por meio de revisões literárias e análises documentais, e dados das integrações em estudo. Pelos resultados gerados, percebe-se que o acordo será benéfico para alguns setores das economias mercosulinas, mas também preocupante e ameaçador para outros.
AS POLÍTICAS PÚBLICAS DE CONTROLE MIGRATÓRIO NO BRASIL SOB AS PERSPECTIVAS DA SEGURANÇA NACIONAL E DOS DIREITOS HUMANOS (2002-2019)
Authors: Silva Paula Cristina Ferreira da , Pereira Alexsandro Eugenio
Published: February 2024

O objetivo deste artigo é entender a problemática da gestão migratória estatal brasileira no que se refere ao controle imigratório, buscando averiguar a influência das perspectivas da segurança nacional e dos direitos humanos nas políticas públicas que regulam o controle imigratório no período de 2002 a 2019. Para analisar as características preponderantes dessas políticas, optou-se por definir essas perspectivas a partir de referenciais teóricos e analíticos, apresentadas na primeira seção do artigo. Em seguida, foi desenvolvida uma análise de conteúdo das legislações brasileiras no período de 2002 a 2019 com base nessas duas perspectivas. Os resultados mostram que 41,6% das legislações brasileiras analisadas no artigo são vinculadas à perspectiva de segurança nacional enquanto o restante (53,4%) está orientado pela perspectiva de direitos humanos. Esses dados indicam que a perspectiva de segurança tem significativa importância, ainda, na orientação das políticas de controle migratório no Brasil, apesar dos avanços promovidos pela Nova Lei de Migrações, aprovada em 2017.
Os ESTADOS UNIDOS NO ACORDO DE PARIS: COMPROMISSOS, CONSEQUÊNCIAS E DESAFIOS
Authors: THAYS  , Brito Renato Victor Lira , Nunes Bruno Moser
Published: February 2024

Os Estados Unidos são o segundo maior emissor de gases de efeito estufa do mundo, logo após a China. Por isso, a contribuição dos Estados Unidos no Acordo de Paris é vista como um gesto importante para conter o aquecimento global. Nesse sentido, o objetivo desta pesquisa é analisar em que medida a saída dos Estados Unidos do Acordo de Paris pode prejudicar o progresso representado pela redução na emissão de gases do efeito estufa, proposta no âmbito da Convenção - Quadro das Nações Unidas sobre a Mudança do Clima (CQNUMC). A partir de uma perspectiva exploratória e com caráter metodológico qualitativo, este debate abrange as questões relacionadas ao campo da Política Ambiental Internacional, especificamente, no contexto da atuação dos Estados Unidos no Acordo de Paris, fator que desencadeia desafios globais.
O COMPORTAMENTO DO ESTADO POR FATORES ENDÓGENOS OS DESAFIOS DA CONTEMPORANEIDADE PARA ABORDAGENS ESTRUTURALISTAS E GENERALIZANTES NAS RELAÇÕES INTERNACIONAIS
Authors: Accioly Filho Lauro Henrique Gomes , Nobre Fábio Rodrigo Ferreira
Published: February 2024

O artigo trabalha um Estudo de Caso sobre o impacto do Lobby Israel na formulação da Política Externa dos Estados Unidos, debatendo a nova revolução behaviorista. A pesquisa investiga falhas de teorias restritas a explicar alterações de interesses por fatores estruturais. Desta maneira, é sinalizado que analisar fenômenos complexos por uma única lente, limitada a certos elementos, restringe e afeta a compreensão sobre o comportamento dos Estados na contemporaneidade.
NOVA GEOPOLÍTICA DA CONTENÇÃO A ESTRATÉGIA GEOPOLÍTICA DOS EUA NA SEGUNDA DÉCADA DO SÉCULO XXI
Authors: Rodrigues Bernardo Salgado
Published: February 2024

Os Estados Unidos e a China são as duas grandes potências do sistema internacional e têm ampliado progressivamente a sua assertividade competitiva. Tal disputa internacional instiga uma base comparativa com a política externa dos EUA no contexto da Guerra Fria sob a geopolítica da contenção. Este artigo tem como objetivo analisar se uma nova versão de contenção estaria sendo utilizada num contexto de disputa geopolítica sino-americana para as próximas décadas. A hipótese principal seria que a política externa de Joe Biden tenha retornado aos preceitos da contenção para inviabilizar a ascensão da China no século XXI. Utilizando o método empírico-dedutivo baseado em revisão bibliográfica e análise primária de documentos oficiais, será realizada uma pesquisa apoiada no realismo nas relações internacionais visando como resultado avaliar os novos arranjos geopolíticos dos EUA baseados em uma Nova Geopolítica de Contenção como instrumento de bloqueio e contenção da China.
SPILLOVERS DE CONHECIMENTO NA OCDE: UMA ANÁLISE COM MGM-SYSTEM
Authors: Silva José Alderir da
Published: February 2024

Na teoria do crescimento endógeno, a inovação e o avanço tecnológico desempenham um papel crucial no crescimento econômico. Essa teoria enfatiza os fatores econômicos internos, sendo os spillovers um dos principais mecanismos que impulsionam o progresso tecnológico e, portanto, o crescimento econômico. Os países ricos são economias que estão próximas da fronteira tecnológica, mas que podem disseminar o conhecimento para países que se encontram atrasados tecnologicamente. Assim, este artigo tem por objetivo principal analisar as relações entre a criação de novas ideias e as algumas variáveis que podem gerar o transbordamento do conhecimento tecnológico entre as economias da OCDE. Os resultados encontrados através do método generalizados de momentos (MGM-System) mostram que as importações, o investimento direto estrangeiro e, principalmente, o gap tecnológico são importantes canais de transbordamento de conhecimento entre as economias estudadas.
MEDIDA INDIRETA DA PRESSÃO ARTERIAL EM PACIENTES OBESOS
Authors:   Hospital Israelita Albert Einstein, Queiroz Godoy Daniel Ana Carolina , Gomes Musa dos Santos Isabela ,   Hospital Sírio-Libanês, Malaman Galhardi Nathalia ,   Universidade Estadual de Campinas. Faculdade de Enfermagem., Miranda Martins Wilson Ana Maria ,   Universidade de São Paulo., Batista dos Santos Pedrosa Rafaela ,   Universidade Estadual de Campinas. Faculdade de Enfermagem.
Published: February 2024

Objetivo: Investigar a produção científica sobre a técnica de medida indireta da pressão arterial em pacientes obesos. Método: Revisão narrativa da literatura, realizada durante o mês de outubro de 2023, nas bases de dados Scopus, PubMed e BVS. Foram incluídos 14 artigos, dos quais nove artigos originais, um artigo de revisão de literatura, um artigo de opinião de especialistas, dois editoriais e uma correspondência. A extração dos dados foi realizada utilizando formulário construído pelos autores com os itens: ano de publicação, país de origem, título do artigo, nome do periódi-co, tipo de estudo, objetivo do estudo e resultados do estudo. Resultados: Foram encontradas pesquisas associadas ao processo de validação de equipamentos de pressão de punho, antebraço e braço, bem como estudos de revisão de literatura e opinião de especialistas sobre as técnicas de medida indireta da pressão arterial em indivíduos obesos. Os achados sugerem que equipamentos validados em obesos devam ser utilizados na prática clínica. Caso os manguitos de longo alcance e de formato apropriado não estejam disponíveis, o procedimento pode ser realizado no antebraço ou no punho. Considerações finais: As evidências sugerem que a técnica da medida indireta da pressão arterial em pacientes obesos deva ser realizada com equipamentos validados para essa população específica. Caso o manguito não possa ser colocado adequadamente na parte superior do braço, o antebraço ou o punho podem ser alternativas ao procedimento
A EXPERIÊNCIA DO SERVIÇO SOCIAL EM HOSPITAL DE ALTA COMPLEXIDADE NA LINHA DO CUIDADO NO PROGRAMA DE CIRURGIA BARIÁTRICA
Authors:   Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo., dos Santos Tania Maria , de Carvalho Oliveira Ana Lucia ,   Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo., Fonseca Amaral da Silva Elaine ,   Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Instituto do Coração, Watanabe Renata ,   Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Instituto do Coração
Published: February 2024

Introdução: A obesidade é um problema de saúde pública global, causando limitações e alterações na vida cotidiana dos pacientes e familiares e consequentemente na qualidade de vida. Neste cenário, o Assistente Social, como integrante da equipe multiprofissional, propõe alternativas de enfrentamento às situações que comprometem o processo de saúde-doença dos pacientes. O estudo tem como objetivo discutir a experiência do Serviço Social em hospital de alta complexidade na linha do cuidado no Programa de Cirurgia Bariátrica do Instituto Central do Hospital das Clínicas da Universidade de São Paulo. Método: O estudo foi realizado por meio de Pesquisa Bibliográfica com o objetivo de reunir informações e dados para a construção da investigação a partir do tema e também da prática profissional com base em artigos científicos, livros referentes ao assunto, além da observação empí-rica, reflexões e vivência profissional cotidiana do Assistente Social no lócus do exercício do trabalho desenvolvido em Equipe Multiprofissional em hospital de alta complexidade. Resultados: Salientamos o papel do Assistente Social que participa de todo o cuidado pré-operatório e pós-operatório, com a oportunidade de vivenciar toda a programação do trabalho coletivo da equipe multiprofissional destinada ao usuário Sistema Único de Saúde (SUS) na programação de cirurgia do Ambulatório do Serviço de Cirurgia Bariátrica e Metabólica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP). Conclusão: É importante ressaltar que o tratamento cirúrgico constitui apenas parte do tratamento integral da obesidade. Necessitamos do envolvimento de toda a sociedade, mobilizando o planejamento de políticas públicas voltadas à promoção da saúde, prevenção, tratamento e recuperação da obesidade mórbida enquanto saúde pública
Implementation of creative problem-solving model with RME approach on mathematics problem-solving ability
Authors: Rahmadi Joko , Wahyu Yoppy , Oktari Viscal
Published: February 2024

This research is motivated by the low problem-solving ability of students caused by focusing on memorizing formulas when answering questions. Innovation is needed to overcome this, one of which is through the innovative implementation of the creative problem-solving model. This study aims to see the effect of students' problem-solving skills through implementing the creative problem-solving model with the RME approach. This study uses a type of quasi-experiment with a non-equivalent control group design in class 6 on the material of building space. The population was 73 students, with a sample of 40 students consisting of 20 experimental classes and 20 control classes with simple random sampling techniques. The ice instrument used is a description test with as many as four questions. The t-test results obtained are Sig. 0.001 with a t-count of 2.387. Based on the test results that have been carried out, there is a positive influence on the implementation of the creative problem-solving model with the RME approach on students' problem-solving skills, and there is an increase in students' problem-solving skills based on the pretest-posttest value of 31.6.
Understanding multiplication concept: Exploring PMRI-enhanced thematic learning using traditional games for primary teachers
Authors: Zakaria Zakaria , Dewantara Andi Harpeni
Published: February 2024

Involving concrete situations and utilizing contexts that are closely related to students' daily lives is highly promising in creating enjoyable and meaningful mathematics learning experiences. One approach that incorporates these ideas is Pendidikan Matematika Realistik Indonesia (PMRI), which is oriented towards the mathematization of everyday experiences. This research aims to investigate how the traditional game 'maggalaceng' could support students’ understanding of multiplication in thematic learning using the PMRI approach. The method employed in this study was design research in the form of workshops involving eight teachers at a public primary school in Bone, South Sulawesi. Data were collected through classroom observations, interviews, and documentation. The results show that the teachers responded positively to integrating PMRI in thematic learning, making learning more enjoyable and meaningful. Specifically, in mathematics, the designed learning trajectory fully assists teachers in exploring alternative perspectives for teaching the concept of multiplication, progressing from the informal to the formal level as a form of repeated addition.
Computational thinking on concept pattern number: A study learning style Kolb
Authors: Purwasih Ratni , Turmudi Turmudi , Dahlan Jarnawi Afgani , Ishartono Naufal
Published: February 2024

This research aimed to determine how the number pattern concept's computational thinking characteristic picture was reviewed from the Kolb model's learning style. The research method used in this study is qualitative descriptive. The research was conducted at one of the state's small schools in Bandung. The research subjects consisted of 29 students in the ninth grade. One of the 29 study issues is selected with assimilator learning styles. The data-gathering techniques used are questionnaire tests, test instruments, and interviews. Angket is used to group subjects into four groups of learning style types. The test instrument was used to describe the computational thinking characteristics of high school students on the concept of number patterns, and the interview was used to strengthen the test summary results of the subject. The results of this study show that the characteristics of computational thinking that each type of learning style dominates are different. Computational thinking students with an assimilator learning style in solving mathematical problems of number patterns can solve issues by involving decomposition, pattern identification, abstraction and generalization, and algorithms. They can generalize patterns using accurate, thorough, complete, and systematic problem-solving strategies.
Development of learning video rotation using Palembang tanjak context to determine students’ mathematical reasoning
Authors: Hasanah Uswatun , Putri Ratu Ilma Indra , Zulkardi Zulkardi
Published: February 2024

This research is essential as a starting point in using learning videos on rotation material assisted by the Palembang tanjak context so that students' mathematical reasoning abilities are good. This research aims to produce a learning video on rotation material using the Palembang tanjak context that is valid and practical, as well as to determine the potential effect of using videos on rotation material using the Palembang tanjak context on students' mathematical reasoning ability. PMRI and collaborative learning approaches were also used in this research. This type of research is a design research type of development studies. The subjects of this study involved 28 students of class IX.A. Data collection techniques were observation, tests, and interviews. The data analysis technique is descriptive. This research resulted in a learning video on rotation material using the context of Palembang tanjak, which was developed to be valid and practical and potentially affected students' mathematical reasoning ability with an average of 67.625. Learning videos on rotation material can be used to train students' mathematical reasoning skills within the Palembang Tanjak context.
Ratio and proportion through realistic mathematics education and pendidikan matematika realistik Indonesia approach: A systematic literature review
Authors: Risdiyanti Irma , Zulkardi Zulkardi , Putri Ratu Ilma Indra , Prahmana Rully Charitas Indra , Nusantara Duano Sapta
Published: February 2024

Foundational mathematical concepts like ratios and proportions are indispensable for solving both everyday problems and those encountered in professional settings. However, many students need help to grasp and apply these concepts effectively, often due to ineffective teaching methods, variations in students' levels of comprehension, and shortcomings in existing learning models. Realistic Mathematics Education (RME) and Pendidikan Matematika Realistik Indonesia (PMRI) have emerged as promising solutions to address these challenges. This study aims to systematically review the literature on ratio and proportion learning design using RME and PMRI approaches. It focuses on three specific research inquiries: profiling the literature, analyzing employed learning designs, and identifying gaps and recommendations for further research in learning design development. Conducted through a Systematic Literature Review (SLR) approach, the research involved planning, implementing, and disseminating review results. One hundred forty-four documents were scrutinized, leading to the identification of 19 pertinent papers. This study provides a comprehensive analysis of the literature on learning design in the context of ratio, proportion, scale, and level, utilizing RME and PMRI approaches while highlighting research gaps and offering insights for future studies. Its findings hold significant implications for educators and researchers seeking to enhance mathematics education through RME and PMRI approaches.
Estruturalismo, Educação e Matemática
Authors: Sales Antonio
Published: February 2024

Este é um trabalho de resgate da contribuição do estruturalismo para a Educação e, sobretudo, para o ensino  da Matemática.  É uma revisão sistemática de literatura que percorre, resumidamente, a trajetória  desse paradigma desde Galois, o jovem matemático, que foi a primeiro a criar a estrutura de grupo e as contribuições de Cantor com a teoria dos conjuntos. Apresenta como Piaget concebeu o nascimento da inteligência na criança a partir da teoria dos grupos  e dos isomorfismos discutidos na Matemática e propostos pelo grupo Bourbaki para o ensino da Matemática. Apresenta também uma crítica  ao programa conhecido como  Matemática Moderna, pelo excesso de formalismo que apresentava.
Assessing Susceptibility to Carbon Dioxide Gas in Three Rat Strains Using the Loss of Righting Reflex
Authors: Merenick Dexter R , Munro Brittany A , Gee Julia M , Pang Daniel SJ
Published: February 2024

Overdose of carbon dioxide gas (CO2) is a common euthanasia method for rodents; however, CO2 exposure activates nociceptors in rats at concentrations equal to or greater than 37% and is reported to be painful in humans at concentrations equal to or greater than 32.5%. Exposure of rats to CO2 could cause pain before loss of consciousness. We used 2 standardized loss of righting reflex (LORR) methods to identify CO2 concentrations associated with unconsciousness in Wistar, Long–Evans, and Sprague–Dawley rats (n = 28 animals per strain). A rotating, motorized cylinder was used to test LORR while the rat was being exposed to increasing concentrations of CO2. LORR was defined based on a 15-second observation period. The 2 methods were 1) a 1-Paw assessment (the righting reflex was considered to be present if one or more paws contacted the cylinder after the rat was positioned in dorsal recumbency), and 2) a 4-Paw assessment (the righting reflex was considered to be present if all 4 paws contacted the cylinder after the rat was positioned in dorsal recumbency). Data were analyzed with Probit regression, and dose-response curves were plotted. 1-Paw EC95 values (CO2 concentration at which LORR occurred for 95% of the population) were Wistar, 27.2%; Long–Evans, 29.2%; and Sprague–Dawley, 35.0%. 4-Paw EC95 values were Wistar, 26.2%; Long–Evans, 25.9%, and Sprague–Dawley, 31.1%. Sprague–Dawley EC95 values were significantly higher in both 1- and 4-Paw tests as compared with Wistar and Long–Evans rats. No differences were detected between sexes for any strain. The 1-Paw EC95 was significantly higher than the 4-Paw EC95 only for Sprague-Dawley rats. These results suggest that a low number of individual rats from the strains studied may experience pain during CO2 euthanasia.
ASTROCITOMA ANAPLASICO DE REGION PINEAL SEGUIMIENTO A 4 AÑOS
Authors: Hernandez Zamora Cesar Ivan , Castañeda Aguayo Franscisco , Valdez Orduño Ricardo , Hernandez Salazar Manuel
Published: February 2024

Introduccion:

Los tumores de la región pineal, representan una variedad heterogénea de neoplasias primarias de baja incidencia, donde se incluyen a los tumores de origen germinal y los tumores del parénquima pineal. El astrocitoma anaplásico es todavía de  una frecuencia más baja en esta región, y su pronóstico de sobrevida de este tipo de tumor es relativamente corto.

Metodo.

Presentamos el caso de una paciente femenina de 16 años de edad con diagnóstico tisular de astrocitoma anaplásico cerebral de región pineal, el tratamiento, evolución  y el resultado en 4 años de seguimiento.

Discusión.

El astrocitoma anaplásico tiene una sobrevida corta de acuerdo a nuestra revisión, y los tumores del parénquima pineal son menos frecuentes que los germinomatosos, el manejo elegido en este caso fue basado en las recomendaciones internacionales, obteniendo un seguimiento de 4 años lo que lo hace un caso de éxito, contrario al pronóstico común de su  histología.

Conclusion.

El astrocitoma anaplasico de la region pineal es un tumor poco frecuente, el haber realizado una resección quirúrgica amplia ante una histología de alta malignidad influye para que la paciente presente una sobrevida libre de enfermedad arriba del promedio, al presentar este caso esperamos aportar un caso a las series de estos tumores con una evolución libre de enfermedad y estable.
Staged Neuroendoscopic Management of a Dandy Walker Malformation Case Presenting with Complex Hydrocephalus
Authors: Theologou Marios , Varoutis Panagiotis , Tsitouras Vassilios
Published: February 2024

Backgroud: Dandy-Walker malformation is a rare congenital condition characterized by alteration of posterior fossa anatomy. Hydrocephalus is a common finding in these patients. VP-shunt placement remains the treatment of choice. Endoscopic Third Ventriculostomy (ETV) is an acceptable alternative for older children. Other techniques have also been proposed.
Case presentation: A full-term infant presented with signs of hydrocephalus. An endoscopic foraminoplasty of the posterior fossa cyst was conducted as a first stage. The cyst’s volume was reduced, without any changes of the supratentorial ventricular dimensions. A month post-surgery signs of hydrocephalus reoccurred. An ETV was performed alongside a fenestration of the tentorium. The toddler was discharged in good condition with amelioration of her symptoms. One month later she presented with recurrent hydrocephalus and subdural hygromas. A shunt was placed in the posterior fossa under endoscopic guidance, and an additional one was introduced in the subdural space. The patient was followed-up for 18 months without any further need for treatment. VP-shunt placement is the treatment of choice.
Discussion: Lushka and Magendie foraminoplasty seems to be ineffective. ETV should be reserved for older children. The ventriculoscope can be employed for positioning the VP-shunt in a specific anatomical region. Subdural hygromas may present after neuroendoscopic treatment. A staged approach may be mandatory for complex hydrocephalus treatment.
Social Aspects of the Image of the World in Russian Folklore: Georges Dumézil and the Frog Princess
Authors:   Institute of Slavic Studies, Russian Academy of Sciences, Petrukhin Vladimir
Published: February 2024

The social dominant of Russian folklore is its peasant basis, associated with the agricultural calendar. This basis is described by a system of universal semantic binary oppositions (Svetlana M. Tolstaya), which did not include social oppositions directly. In the epic, the farmer (Mikula Selyaninovich) turns out to be stronger than the warrior-hero. Wedding folklore is focused on imitation of the ancient Russian social elites (“princes”, “boyars”). The motif of the royal wedding is also connected with the fairy tale about the frog princess: the three royal sons must marry brides, who will be determined by for-tune-telling archery. The arrows of the elder brothers fall into prestigious courts, where the princely/boyar and general/merchant daughters are waiting for them. The arrow of Ivan Tsarevich falls into the swamp in the paws of a frog. This plot of archery corresponds (in the cultural anthropology of G. Dumézil) to the archaic Indo-European model of the distribution of power between three brothers ― cultural heroes who embody the three social functions (the highest is sacred, royal, the middle is military, the lowest is “economic” (providing fertility). This structure corresponds to the universal cosmologi-cal trinomial model ― the top (celestial sphere), the middle zone (the atmosphere, the earth’s surface), and the fertile chthonic bottom (soil, underworld). The trifunctional social structure is also conveyed by the spiritual “Verse on the Golubinaya kniga”, where the three estates are made from the members of the first man ― Adam. Probably, these ternary structures are associated with the archaic Indo-European model, transmitted to the Slavic tradition through the ancient mediation of the Iranian (Indo-Iranian, studied by Vladimir N. Toporov) tradition.
Berries in the Slavic Oral and Written Tradition of Dream Interpretation
Authors:   Institute of Slavic Studies, Russian Academy of Sciences, Gura Aleksandr
Published: February 2024

A parallel examination of berries in the oral and written traditions of dream interpretation allows us to compare their symbolism in both corpuses of texts and to identify the interaction and mutual influence between them, as well as to trace the process of filiation of dream interpretations in dream books. Berries are included in two extensive groups of oral folk interpretations, one of which foreshadows tears, the other ― sores on the skin. For the written tradition, both of these models of dream interpretation are not typical. Occasionally, berries and cherries are found as a symbol of tears in dream books, in which one can see the influence of oral tradition. In one rare case, both traditions are brought together by the motif of hope in the symbolism of cherries. The interpretation of berries in the Slavic literary tradition goes back mainly to the ancient dream book of Artemidorus. With another source ― so called Akhmet’s dream book ― some features of the symbolism of plums in European and Arabic dream books are related by origin. The symbolism of cherries and plums, which characterizes time, is interesting. One can observe how the “perishable” sign, which caused the symbolism of transience in cherries, develops new meanings associated with time ― it symbolizes impermanence and aging. In plums, the symbolism of illness and fear as an obstacle generates a motive of slowing down and stretching time, and the symbolic meanings of boredom and longing. A distinctive feature of plums in the oral tradition is the metaphorical symbolism of tears, teals and bruises. Otherwise, in the folk interpretations of plums, especially among the South Slavs, one can see a strong influence of the written tradition.
Young Scholars Conference “Slavic World: Community and Diversity”. Moscow, 23–24 May 2023. Section “History”
Authors:   Institute of Slavic Studies, Russian Academy of Sciences, Evstafyev Nikita
Published: February 2024

On May 23–24, 2023, a regular conference for young scholars was held, dedicated to the Day of Slavic Writing and Culture. As with the previous events, the conference was held in a mixed format: at the Institute of Slavic Studies and on the ZOOM platform. The History section was attended by young scholars from various cities of Russia and abroad: Moscow, St. Petersburg, Voronezh, Kazan, Rostov-on-Don, Prešov (Slovakia) and Pécs (Hungary). The papers covered a wide range of issues of the history of Slavic countries and peoples, from the early Middle Ages to the beginning of the XXI century. The participants of the conference touched upon the problems of national identity, borders and frontiers, preservation of historical memory, international relations, as well as issues of cultural history of Slavic peoples. The authors involved a wide range of sources in their work, including medieval literature, diplomatic and archival documents, as well as newspaper and magazine articles. Most of the reports aroused the interest of the audience and led to lively discussions. The discussion was attended not only by the participants of the conference, but also by the scholars of the Institute of Slavic Studies of the Russian Academy of Sciences, many of whom also acted as moderators of individual subsections. Thus, as in previous years, the conference of young scholars «Slavic World: Community and Diversity» served as a good platform for the exchange of experience and the establishment of closer ties between various scientific institutions. The proceedings of the conference will be summed up in a published collection of abstracts.
Restoring the Identity: Joseph Saunders, Engraver and Art Historian, 1773−1854
Authors:   Institute of Slavic Studies, Russian Academy of Sciences, Svirida Inessa
Published: February 2024

This edition presents the last and previously unpublished manuscript of Inessa I. Svirida (1937–2019), Doctor habilitatus of History, Professor and former Principal Researcher of the Institute for Slavic Studies of the Russian Academy of Sciences. It examines for the first time the life of the British engraver, mentor, theorist and art historian Joseph Saunders (1773–1854), who lived and worked in St. Petersburg, Vilna and Florence. The author draws heavily on the archival materials and memoirs of the artist’s contemporaries, as well as on the letters, poetry and other writings of Saunders himself. The publication is richly illustrated and is addressed to both academics and the wider audience, interested in the epoch of the late 18th — first half of the 19th century.