bluuebunny/crossref_metadata_2025 huggingface dataset:
Automated Quantum Hardware Selection for Quantum Workflows
Authors: Weder Benjamin , Barzen Johanna , Leymann Frank , Salm Marie
Published: April 2021

The execution of a quantum algorithm typically requires various classical pre- and post-processing tasks. Hence, workflows are a promising means to orchestrate these tasks, benefiting from their reliability, robustness, and features, such as transactional processing. However, the implementations of the tasks may be very heterogeneous and they depend on the quantum hardware used to execute the quantum circuits of the algorithm. Additionally, today’s quantum computers are still restricted, which limits the size of the quantum circuits that can be executed. As the circuit size often depends on the input data of the algorithm, the selection of quantum hardware to execute a quantum circuit must be done at workflow runtime. However, modeling all possible alternative tasks would clutter the workflow model and require its adaptation whenever a new quantum computer or software tool is released. To overcome this problem, we introduce an approach to automatically select suitable quantum hardware for the execution of quantum circuits in workflows. Furthermore, it enables the dynamic adaptation of the workflows, depending on the selection at runtime based on reusable workflow fragments. We validate our approach with a prototypical implementation and a case study demonstrating the hardware selection for Simon’s algorithm.
Influence of Menstrual Cycle or Hormonal Contraceptive Phase on Energy Intake and Metabolic Hormones—A Pilot Study
Authors: Ihalainen Johanna K. , Löfberg Ida , Kotkajuuri Anna , Kyröläinen Heikki , Hackney Anthony C. , Taipale-Mikkonen Ritva S.
Published: April 2021

Sex hormones are suggested to influence energy intake (EI) and metabolic hormones. This study investigated the influence of menstrual cycle (MC) and hormonal contraceptive (HC) cycle phases on EI, energy availability (EA), and metabolic hormones in recreational athletes (eumenorrheic, NHC = 15 and monophasic HC-users, CHC = 9). In addition, 72-h dietary and training logs were collected in addition to blood samples, which were analyzed for 17β-estradiol (E2), progesterone (P4), leptin, total ghrelin, insulin, and tri-iodothyronine (T3). Measurements were completed at four time-points (phases): Bleeding, mid-follicular (FP)/active 1, ovulation (OVU)/active 2, mid-luteal (LP)/inactive in NHC/CHC, respectively. As expected, E2 and P4 fluctuated significantly in NHC (p < 0.05) and remained stable in CHC. In NHC, leptin increased significantly between bleeding and ovulation (p = 0.030) as well as between FP and OVU (p = 0.022). No group differences in other measured hormones were observed across the MC and HC cycle. The mean EI and EA were similar between phases, with no significant differences observed in macronutrient intake over either the MC or HC. While the MC phase might have a small, but statistically significant effect on leptin, the findings of the present study suggest that the MC or HC phase does not significantly alter ad libitum EI or EA in recreational athletes.
Sources of Light Density Microplastic Related to Two Agricultural Practices: The Use of Compost and Plastic Mulch
Authors: van Schothorst Benjamin , Beriot Nicolas , Huerta Lwanga Esperanza , Geissen Violette
Published: April 2021

Microplastics (MPs) constitute a known, undesirable contaminant of the ecosystems. Land-based pollution is considered to be an important contributor, but microplastics in the terrestrial environment remains largely unquantified. Some agriculture practices, such as plastic mulch and compost application, are suspected to be major sources of microplastics as plastics are exposed to weathering or are present in organic fertilizers. The overall aim of this research is to bridge the terrestrial plastic contamination information gap, focusing on light density microplastics in two vegetable production systems in Southeast Spain and in the Netherlands. The selected farmer in Spain used plastic mulch for more than 12 years whereas the two farmers in the Netherlands annually applied 10 t ha−1 compost for the past 7 and 20 years. Samples from two different depths were collected: 0–10 cm and 10–30 cm. High quality compost samples originating from municipal organic waste and from garden and greenhouse waste were obtained from two Dutch compost plants. All samples from both Spanish (n = 29) and Dutch (n = 40) soils were contaminated by microplastics, containing 2242 ± 984 MPs kg−1 and 888 ± 500 MPs kg−1, respectively. Compost samples from municipal organic waste (n = 9) were more contaminated than the ones from garden and green house wastes (n = 19), with, respectively, 2800 ± 616 MPs kg−1 and 1253 ± 561 MPs kg−1. These results highlight the need for studies focusing on the effects of microplastics in the environment and the need for monitoring campaigns and the implementation of thresholds to regulate the microplastic contamination.
Organic Black Beans (Phaseolus vulgaris L.) from Rio de Janeiro State, Brazil, Present More Phenolic Compounds and Better Nutritional Profile Than Nonorganic
Authors: Barreto Nathália M. B. , Pimenta Natália G. , Braz Bernardo F. , Freire Aline S. , Santelli Ricardo E. , Oliveira Angélica C. , Bastos Lucia H. P. , Cardoso Maria Helena W. M. , Monteiro Mariana , Diogenes Maria Eduarda L. , Perrone Daniel
Published: April 2021

Brazil is the world’s third largest common bean (Phaseolus vulgaris L.) producer, and 60% of its population consumes this legume. Although organic farming is a sustainable alternative to nonorganic agriculture, its effect on chemical composition is still controversial. Therefore, the aim of this study was to investigate differences in the nutritional and phenolic compounds profiles between organically and nonorganically produced Brazilian black beans. Samples were obtained from the same harvest periods and from near geographical locations at metropolitan and coastal regions of Rio de Janeiro state, Brazil. No residues of 294 evaluated pesticides were detected in the samples. In both regions, organic beans had 17% fewer lipids, 10% less phytate and 20% more proteins when compared to nonorganic ones. Sixteen different phenolic compounds were identified as soluble and insoluble forms in black beans, with anthocyanins being the most abundant (on average, 66%). In both regions, soluble and total phenolic compounds contents in organic beans were consistently higher (on average, 25% and 28%, respectively) than in nonorganic ones. Our results show that organic farming improves the nutritional profile and increases the phenolic compounds content of black beans.
Rescuing Flavor Identity and Dynamic Perception in Puréed Dishes; A Restructuring Solution for the Purée Diet
Authors: Carrillo Elizabeth , Laguna Laura , Arancibia Carla , Tárrega Amparo
Published: April 2021

With age, difficulties with masticating and swallowing means food consistency and structure must be modified, such as puréeing food. However, elderly consumers have reported that puréed food’s taste lacks appeal. This study shows how puréeing food changes the recognition and dynamics of flavors and new strategies to improve them. Further, to measure the identification and dynamics of flavor, a new sensory method was investigated that combined Free Choice and Temporal Order of Sensation (Free-TOS). Three dishes (macaroni, pizza, and potato salad), their purées, and three pasta purées with added flavors (cheese and dry-cured ham; added directly or as an oil in water emulsion or using two types of emulsions (oil in water and water in oil) were assessed by three groups of 60 consumers using Free-TOS. Results showed that in the purée the frequency of mentioned sensations decreased compared with the dish, as it was more difficult to identify flavors. Adding flavors in powder form only allowed a cheese/ham flavor identification, but in the purées with emulsions, it was possible to identify the dry-cured ham flavor. Therefore, this study showed that the Free-TOS method does not need a predetermined attribute list and registers the actual identified flavors and their order of appearance.
Visual Analytics for Climate Change Detection in Meteorological Time-Series
Authors: Vuckovic Milena , Schmidt Johanna
Published: April 2021

The importance of high-resolution meteorological time-series data for detection of transformative changes in the climate system is unparalleled. These data sequences allow for a comprehensive study of natural and forced evolution of warming and cooling tendencies, recognition of distinct structural changes, and periodic behaviors, among other things. Such inquiries call for applications of cutting-edge analytical tools with powerful computational capabilities. In this regard, we documented the application potential of visual analytics (VA) for climate change detection in meteorological time-series data. We focused our study on long- and short-term past-to-current meteorological data of three Central European cities (i.e., Vienna, Munich, and Zürich), delivered in different temporal intervals (i.e., monthly, hourly). Our aim was not only to identify the related transformative changes, but also to assert the degree of climate change signal that can be derived given the varying granularity of the underlying data. As such, coarse data granularity mostly offered insights on general trends and distributions, whereby a finer granularity provided insights on the frequency of occurrence, respective duration, and positioning of certain events in time. However, by harnessing the power of VA, one could easily overcome these limitations and go beyond the basic observations.
New Challenges Arising in Engineering Problems with Fractional and Integer Order
Authors: Baskonus Haci Mehmet , Sánchez Ruiz Luis Manuel , Ciancio Armando
Published: April 2021

Mathematical models have been frequently studied in recent decades in order to obtain the deeper properties of real-world problems [...]
Knowing Ourselves: Nietzsche, the Practice of Genealogy, and the Overcoming of Self-Estrangement
Authors: Merrick Allison
Published: April 2021

By centering Nietzsche’s philosophical methods, notably the practice of genealogy, this article addresses how our moral values developed, and how, while they once worked to address certain needs, these values now may perpetuate our self-misunderstandings. In conversation first with Nehamas and Geuss, and then with Reginster, I reconstruct the two dominant conceptions of the practice of genealogy in Nietzsche Studies. I argue that when history is plainly in view, authors have a tendency to remove necessity and psychology from the picture; when necessity and psychology are sharply in focus, commentators are likely to lose sight of history. In keeping all dimensions in the picture, I argue that we obtain a richer and more textured account of the genealogical mode of inquiry. Moreover, I demonstrate that as a psycho-historical mode of inquiry, the normative force of genealogy is immanent to the system of evaluation that is under consideration, which gives Nietzsche’s version of the philosophical practice of genealogy an advantage over more contemporary accounts.
QTL Analysis of Five Morpho-Physiological Traits in Bread Wheat Using Two Mapping Populations Derived from Common Parents
Authors: Vitale Paolo , Fania Fabio , Esposito Salvatore , Pecorella Ivano , Pecchioni Nicola , Palombieri Samuela , Sestili Francesco , Lafiandra Domenico , Taranto Francesca , De Vita Pasquale
Published: April 2021

Traits such as plant height (PH), juvenile growth habit (GH), heading date (HD), and tiller number are important for both increasing yield potential and improving crop adaptation to climate change. In the present study, these traits were investigated by using the same bi-parental population at early (F2 and F2-derived F3 families) and late (F6 and F7, recombinant inbred lines, RILs) generations to detect quantitative trait loci (QTLs) and search for candidate genes. A total of 176 and 178 lines were genotyped by the wheat Illumina 25K Infinium SNP array. The two genetic maps spanned 2486.97 cM and 3732.84 cM in length, for the F2 and RILs, respectively. QTLs explaining the highest phenotypic variation were found on chromosomes 2B, 2D, 5A, and 7D for HD and GH, whereas those for PH were found on chromosomes 4B and 4D. Several QTL detected in the early generations (i.e., PH and tiller number) were not detected in the late generations as they were due to dominance effects. Some of the identified QTLs co-mapped to well-known adaptive genes (i.e., Ppd-1, Vrn-1, and Rht-1). Other putative candidate genes were identified for each trait, of which PINE1 and PIF4 may be considered new for GH and TTN in wheat. The use of a large F2 mapping population combined with NGS-based genotyping techniques could improve map resolution and allow closer QTL tagging.
Municipal Solid Waste Management and Adverse Health Outcomes: A Systematic Review
Authors: Vinti Giovanni , Bauza Valerie , Clasen Thomas , Medlicott Kate , Tudor Terry , Zurbrügg Christian , Vaccari Mentore
Published: April 2021

Municipal solid waste (MSW) can pose a threat to public health if it is not safely managed. Despite prior research, uncertainties remain and refurbished evidence is needed along with new approaches. We conducted a systematic review of recently published literature to update and expand the epidemiological evidence on the association between MSW management practices and resident populations’ health risks. Studies published from January 2005 to January 2020 were searched and reviewed following PRISMA guidelines. Eligible MSW treatment or disposal sites were defined as landfills, dumpsites, incinerators, waste open burning, transfer stations, recycling sites, composting plants, and anaerobic digesters. Occupational risks were not assessed. Health effects investigated included mortality, adverse birth and neonatal outcomes, cancer, respiratory conditions, gastroenteritis, vector-borne diseases, mental health conditions, and cardiovascular diseases. Studies reporting on human biomonitoring for exposure were eligible as well. Twenty-nine studies were identified that met the inclusion criteria of our protocol, assessing health effects only associated with proximity to landfills, incinerators, and dumpsites/open burning sites. There was some evidence of an increased risk of adverse birth and neonatal outcomes for residents near each type of MSW site. There was also some evidence of an increased risk of mortality, respiratory diseases, and negative mental health effects associated with residing near landfills. Additionally, there was some evidence of increased risk of mortality associated with residing near incinerators. However, in many cases, the evidence was inadequate to establish a strong relationship between a specific exposure and outcomes, and the studies rarely assessed new generation technologies. Evidence gaps remain, and recommendations for future research are discussed.
Children’s Play and Independent Mobility in 2020: Results from the British Children’s Play Survey
Authors: Dodd Helen F. , FitzGibbon Lily , Watson Brooke E. , Nesbit Rachel J.
Published: April 2021

The British Children’s Play Survey was conducted in April 2020 with a nationally representative sample of 1919 parents/caregivers with a child aged 5–11 years. Respondents completed a range of measures focused on children’s play, independent mobility and adult tolerance of and attitudes towards risk in play. The results show that, averaged across the year, children play for around 3 h per day, with around half of children’s play happening outdoors. Away from home, the most common places for children to play are playgrounds and green spaces. The most adventurous places for play were green spaces and indoor play centres. A significant difference was found between the age that children were reported to be allowed out alone (10.74 years; SD = 2.20 years) and the age that their parents/caregivers reported they had been allowed out alone (8.91 years; SD = 2.31 years). A range of socio-demographic factors were associated with children’s play. There was little evidence that geographical location predicted children’s play, but it was more important for independent mobility. Further, when parents/caregivers had more positive attitudes around children’s risk-taking in play, children spent more time playing and were allowed to be out of the house independently at a younger age.
Dependent, Poorer, and More Care-Demanding? An Analysis of the Relationship between Being Dependent, Household Income, and Formal and Informal Care Use in Spain
Authors: Rodríguez-Sánchez Beatriz , Pascual Sáez Marta , Cantarero-Prieto David
Published: April 2021

Population ageing is one of the current challenges that most societies are facing, with great implications for health systems and social services, including long-term care. This increasing long-term care use is particularly rising for dependent older people, motivating the implementation of regional dependency laws to ensure their care needs’ coverage. Using data from the Survey of Health, Ageing, and Retirement in Europe (SHARE) from the year 2004 until 2017, the aim of this study is to assess the impact that the Spanish System for Personal Autonomy and Dependency might have on (i) household income, according to different needs for care levels, by running Generalized Linear Models (GLMs); and (ii) formal and informal care use depending on the income-related determinant through the performance of logit random-effects regression models. We show that the different degrees of needs for personal care are associated with a lower household income, being associated with an income reduction from €3300 to nearly €3800, depending on the covariates included, per year for the more severely in-need-for-care older adults. Moreover, our findings point towards a higher use of formal and informal care services by the moderate and severe dependents groups, regardless of the household income group and time period. Bearing in mind the demographic ageing, our results highlight the need for the identification of potentially vulnerable populations and the efficient planification of long-term care systems and social support services.
Comparison of the Effectiveness of an Abbreviated Program versus a Standard Program in Mindfulness, Self-Compassion and Self-Perceived Empathy in Tutors and Resident Intern Specialists of Family and Community Medicine and Nursing in Spain
Authors: Pérula-de Torres Luis , Verdes-Montenegro-Atalaya Juan , Melús-Palazón Elena , García-de Vinuesa Leonor , Valverde Francisco , Rodríguez Luis , Lietor-Villajos Norberto , Bartolomé-Moreno Cruz , Moreno-Martos Herminia , García-Campayo Javier , González-Santos Josefa , Rodríguez-Fernández Paula , León-del-Barco Benito , Soto-Cámara Raúl , González-Bernal Jerónimo ,   The MINDUUDD Collaborative Study Group
Published: April 2021

Health professionals are among the most vulnerable to work stress and emotional exhaustion problems. These health professionals include tutors and resident intern specialists, due to the growing demand for the former and the high work overload of the latter. Mindfulness training programs can support these professionals during times of crisis, such as the current global pandemic caused by the coronavirus-19 disease. The objective of this study was to compare the effectiveness of an abbreviated Mindfulness-Based Stress Reduction (MBSR) and Mindful Self-Compassion (MSC) training program in relation to a standard training program on the levels of mindfulness, self-compassion, and self-perceived empathy in tutors and resident intern specialists of Family and Community Medicine and Nursing. A total of 112 professionals attached to six Spanish National Health System teaching units (TUs) participated in this randomized and controlled clinical trial. Experimental Group (GE) participants were included in the standard or abbreviated MBSR programs. The Five Facet Mindfulness Questionnaire (FFMQ), the Self-Compassion Scale short form (SCS-SF), and the Jefferson Scale of Physician Empathy (JSPE) were administered three times during the study: before, immediately after, and 3 months after the intervention. Adjusted covariance analysis (ANCOVA), using pretest scores as the covariate, showed a significant increase in mindfulness (F(2,91) = 3.271; p = 0.042; η2 = 0.067) and self-compassion (F(2,91) = 6.046; p = 0.003; η2 = 0.117) in the post-test visit, and in self-compassion (F(2,79) = 3.880; p = 0.025; η2 = 0.089) in the follow-up visit, attributable to the implementation of the standard training program. The standard MBSR and MSC training program improves levels of mindfulness and self-compassion, and promotes long-lasting effects in tutors and resident intern specialists. New studies are needed to demonstrate the effectiveness of abbreviated training programs.
Impact of Fertilizer on Crop Yield and C:N:P Stoichiometry in Arid and Semi-Arid Soil
Authors: Liu Qiang , Xu Hongwei , Yi Haijie
Published: April 2021

Fertilization can significantly affect the quality of crop and soil. To determine the effects of long-term fertilization on crop yield and carbon:nitrogen:phosphorus (C:N:P) stoichiometry in soil, a study was conducted on the terraced fields of the Loess Plateau from 2007 to 2019. Nine fertilization treatments were included: no fertilizer; organic fertilizer (O); organic and nitrogen fertilizers (ON); organic, nitrogen, and phosphorus fertilizers (ONP); organic and phosphorus fertilizers (OP); phosphorus and nitrogen fertilizers; potash and nitrogen fertilizers; potash, nitrogen, and phosphorus fertilizers; and potash and phosphorus fertilizers. Under these treatments except for CK and PK, crop yields initially decreased but later increased. The nutrient content and C:N:P stoichiometry increased in soil depth of 0–20 cm. The soil available nutrients did not change significantly with the duration of fertilization. The O, ON, ONP, and OP had the most evident effect on the enhancement of soil nutrient content, whereas O and ON had the most evident effect on the increase in soil organic carbon (SOC):total phosphorus (TP) and total nitrogen (TN):TP. In soil depth of 0–20 cm, crop yield, SOC:TN, SOC:TN, SOC:TP, and TN:TP significantly correlated with soil nutrients. This study indicated that long-term fertilization can effectively improve crop yield, soil fertility, and soil C:N:P stoichiometry. Meanwhile, the single application of an organic fertilizer or the combination of organic and nitrogen fertilizers can improve the condition of nitrogen limitation in arid and semi-arid areas.
Cancer Incidence and Mortality among Petroleum Industry Workers and Residents Living in Oil Producing Communities: A Systematic Review and Meta-Analysis
Authors: Onyije Felix M. , Hosseini Bayan , Togawa Kayo , Schüz Joachim , Olsson Ann
Published: April 2021

Petroleum extraction and refining are major sources of various occupational exposures and of air pollution and may therefore contribute to the global cancer burden. This systematic review and meta-analysis is aimed at evaluating the cancer risk in petroleum-exposed workers and in residents living near petroleum facilities. Relevant studies were identified and retrieved through PubMed and Web of Science databases. Summary effect size (ES) and 95% confidence intervals (CI) were analysed using random effect models, and heterogeneity across studies was assessed (I2). Overall, petroleum industry work was associated with an increased risk of mesothelioma (ES = 2.09, CI: 1.58–2.76), skin melanoma (ES = 1.34, CI: 1.06–1.70 multiple myeloma (ES =1.81, CI: 1.28–2.55), and cancers of the prostate (ES = 1.13, Cl: 1.05–1.22) and urinary bladder (ES = 1.25, CI: 1.09–1.43) and a decreased risk of cancers of the esophagus, stomach, colon, rectum, and pancreas. Offshore petroleum work was associated with an increased risk of lung cancer (ES = 1.20; 95% CI: 1.03–1.39) and leukemia (ES = 1.47; 95% CI: 1.12–1.92) in stratified analysis. Residential proximity to petroleum facilities was associated with childhood leukemia (ES = 1.90, CI: 1.34–2.70). Very few studies examined specific exposures among petroleum industry workers or residents living in oil producing communities. The present review warrants further studies on specific exposure levels and pathways among petroleum-exposed workers and residents living near petroleum facilities.
The Impact of COVID-19 Lockdown on Health Behaviors among Students of a French University
Authors: Tavolacci Marie Pierre , Wouters Edwin , Van de Velde Sarah , Buffel Veerle , Déchelotte Pierre , Van Hal Guido , Ladner Joel
Published: April 2021

This study aimed to determine the changes in health behaviors among students of a French university during the COVID-19 lockdown. An online retrospective survey was distributed to Rouen-Normandy University students at the end of the COVID-19 lockdown (13th March–11th May 2020). Voluntary university students were included. Data collected were on socio-demographics, academic environment, COVID19 concerns, tobacco smoking, binge drinking, cannabis use, and physical activity in the periods before and during COVID-19 lockdown. The survey was completed by 3671 university students (mean age 20.9 ± 2.47 years, 72.9% female). Significantly favorable changes between the periods before and during COVID-19 were reported for tobacco smoking (18.5% vs. 14.8%), binge drinking (35.9% vs. 9.3%) and cannabis use (5.6% vs. 3.2%) and unfavorable changes for moderate (79.4% vs. 67.9%) and vigorous physical activity (62.5% vs. 59.1%). After logistic regression, factors associated with unfavorable changes in tobacco smoking and with favorable changes in vigorous physical activity were the worry of not validating the academic year and stress related to changes in the mode of teaching, respectively. For each health behavior, unfavorable changes were associated with higher depression levels, and male gender. Then as a decrease, mainly in binge drinking was observed during the COVID-19 lockdown, care must be taken to prevent university students from resuming binge drinking after the end of the lockdown. Health-promotion strategies directed at adopting or maintaining positive mental health and promoting physical activity should be developed for university students to better manage future lockdown periods.
Indicators of Targeted Physical Fitness in Judo and Jujutsu—Preliminary Results of Research
Authors: Cynarski Wojciech J. , Słopecki Jan , Dziadek Bartosz , Böschen Peter , Piepiora Paweł
Published: April 2021

(1) Study aim: This is a comparative study for judo and jujutsu practitioners. It has an intrinsic value. The aim of this study was to showcase a comparison of practitioners of judo and a similar martial art jujutsu with regard to manual abilities. The study applied the measurement of simple reaction time in response to a visual stimulus and handgrip measurement. (2) Materials and Methods: The group comprising N = 69 black belts from Poland and Germany (including 30 from judo and 39 from jujutsu) applied two trials: “grasping of Ditrich rod” and dynamometric handgrip measurement. The analysis of the results involved the calculations of arithmetic means, standard deviations, and Pearson correlations. Analysis of the differences (Mann–Whitney U test) and Student’s t-test were also applied to establish statistical differences. (3) Results: In the test involving handgrip measurement, the subjects from Poland (both those practicing judo and jujutsu) gained better results compared to their German counterparts. In the test involving grasping of Ditrich rod, a positive correlation was demonstrated in the group of German judokas between the age and reaction time of the subjects (rxy = 0.66, p < 0.05), as well as in the group of jujutsu subjects between body weight and the reaction time (rxy = 0.49, p < 0.05). A significant and strong correlation between handgrip and weight was also established for the group of German judokas (rxy = 0.75, p < 0.05). In Polish competitors, the correlations were only established between the age and handgrip measurements (rxy = 0.49, p < 0.05). (4) Conclusions: Simple reaction times in response to visual stimulation were shorter in the subjects practicing the martial art jujutsu. However, the statement regarding the advantage of the judokas in terms of handgrip force was not confirmed by the results.
Co-Infections in Critically Ill Patients with or without COVID-19: A Comparison of Clinical Microbial Culture Findings
Authors: Cultrera Rosario , Barozzi Agostino , Libanore Marco , Marangoni Elisabetta , Pora Roberto , Quarta Brunella , Spadaro Savino , Ragazzi Riccardo , Marra Anna , Segala Daniela , Volta Carlo Alberto
Published: April 2021

Co-infections in critically ill patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have an important impact on the outcome of coronavirus disease 2019 (COVID-19). We compared the microbial isolations found in COVID-19 patients hospitalized in an intensive care unit (ICU) with those in a non-COVID-19 ICU from 22 February to 30 April 2020 and in the same period of 2019. We considered blood, urine or respiratory specimens obtained with bronchoalveolar lavage (BAL) or bronchial aspirate (BASP), collected from all patients admitted in ICUs with or without COVID-19 infection. We found a higher frequency of infections due to methicillin-resistant (MR) staphylococci, vancomycin-resistant Enterococcus faecium, carbapenem-resistant Acinetobacter baumannii and Candida parapsilosis in COVID-19-positive patients admitted in ICUs compared to those who were COVID-19 negative. Carbapenem-resistant Pseudomonas aeruginosa was more frequently isolated from patients admitted in non-COVID-19 ICUs. Several conditions favor the increased frequency of these infections by antibiotic-resistant microorganisms. Among all, the severity of the respiratory tracts was definitely decisive, which required assisted ventilation with invasive procedures. The turnover in the ICU of a large number of patients in a very short time requiring urgent invasive interventions has favored the not always suitable execution of assistance procedures. No less important is the increased exposure to infectious risk from bacteria and fungi in patients with severe impairment due to ventilation. The highest costs for antifungal drugs were shown in the ICU-COVID group.
The Water Safety Plan Approach: Application to Small Drinking-Water Systems—Case Studies in Salento (South Italy)
Authors: Serio Francesca , Martella Lucia , Imbriani Giovanni , Idolo Adele , Bagordo Francesco , De Donno Antonella
Published: April 2021

Background: The quality of water for human consumption is an objective of fundamental importance for the defense of public health. Since the management of networks involves many problems of control and efficiency of distribution, the Water Safety Plan (WSP) was introduced to address these growing problems. Methods: WSP was applied to three companies in which the water resource assumes central importance: five water kiosks, a third-range vegetable processing company, and a residence and care institution. In drafting the plan, the terms and procedures designed and tested for the management of urban distribution systems were applied to safeguard the resource over time. Results: The case studies demonstrated the reliability of the application of the model even to small drinking-water systems, even though it involved a greater effort in analyzing the incoming water, the local intended use, and the possibilities for managing the containment of the dangers to which it is exposed. This approach demonstrates concrete effectiveness in identifying and mitigating the dangers of altering the quality of water. Conclusions: Thanks to the WSP applied to small drinking-water systems, we can move from management that is focused mainly on verifying the conformity of the finished product to the creation of a global risk assessment and management system that covers the entire water supply chain.
SARS/MERS/SARS-CoV-2 Outbreaks and Burnout Syndrome among Healthcare Workers. An Umbrella Systematic Review
Authors: Magnavita Nicola , Chirico Francesco , Garbarino Sergio , Bragazzi Nicola Luigi , Santacroce Emiliano , Zaffina Salvatore
Published: April 2021

The coronavirus-19 (COVID-19) pandemic is putting a severe strain on all healthcare systems. Several occupational risk factors are challenging healthcare workers (HCWs) who are at high risk of mental health outcomes, including Burnout Syndrome (BOS). BOS is a psychological syndrome characterized by emotional exhaustion, depersonalization, and low personal accomplishment. An umbrella review of systematic reviews and meta-analyses concerning BOS and coronavirus (SARS/MERS/SARS-CoV-2) outbreaks was carried out on PubMed Central/Medline, Cochrane Library, PROSPERO, and Epistemonikos databases. Data relating to COVID-19 is insufficient, but in previous SARS and MERS outbreaks about one-third of HCWs manifested BOS. This prevalence rate is similar to the figure recorded in some categories of HCWs exposed to chronic occupational stress and poor work organization during non-epidemic periods. Inadequate organization and worsening working conditions during an epidemic appear to be the most likely causes of BOS. Preventive care and workplace health promotion programs could be useful for protecting healthcare workers during pandemics, as well as during regular health activities.
Individual-Level Determinants of Lifestyle Behavioral Changes during COVID-19 Lockdown in the United States: Results of an Online Survey
Authors: Zhang Xiaotao , Oluyomi Abiodun , Woodard LeChauncy , Raza Syed Ahsan , Adel Fahmideh Maral , El-Mubasher Ola , Byun Jinyoung , Han Younghun , Amos Christopher I. , Badr Hoda
Published: April 2021

This study examined individual-level determinants of self-reported changes in healthy (diet and physical activity) and addictive (alcohol use, smoking, and vaping) lifestyle behaviors during the initial COVID-19 lockdown period in the USA. A national online survey was administered between May and June 2020 that targeted a representative U.S. sample and yielded data from 1276 respondents, including 58% male and 50% racial/ethnic minorities. We used univariate and multivariable linear regression models to examine the associations of sociodemographic, mental health, and behavioral determinants with self-reported changes in lifestyle behaviors. Some study participants reported increases in healthy lifestyle behaviors since the pandemic (i.e., 36% increased healthy eating behaviors, and 33% increased physical activity). However, they also reported increases in addictive lifestyle behaviors including alcohol use (40%), tobacco use (41%), and vaping (46%). With regard to individual-level determinants, individuals who reported adhering to social distancing guidelines were also more likely to report increases in healthy lifestyle behaviors (β = 0.12, 95% CI 0.04 to 0.21). Conversely, women (β = −0.37, 95% CI −0.62 to −0.12), and unemployed individuals (β = −0.33, 95% CI −0.64 to −0.02) were less likely to report increases in healthy lifestyle behaviors. In addition, individuals reporting anxiety were more likely to report increases in addictive behaviors (β = 0.26, 95% CI 0.09 to 0.43). Taken together, these findings suggest that women and unemployed individuals may benefit from interventions targeting diet and physical activity, and that individuals reporting anxiety may benefit from interventions targeting smoking and alcohol cessation to address lifestyle changes during the pandemic.
The Relationship between Suicidality and Socio-Demographic Variables, Physical Disorders, and Psychiatric Disorders: Results from the Singapore Mental Health Study 2016
Authors: Ganesh Kudva Kundadak , Abdin Edimansyah , Vaingankar Janhavi Ajit , Chua Boon Yiang , Shafie Saleha , Verma Swapna Kamal , Fung Daniel Shuen Sheng , Heng Mok Kwee Derrick , Chong Siow Ann , Subramaniam Mythily
Published: April 2021

Suicidality encompasses suicidal ideation, plans, and attempts. This paper aims to establish associations between suicidality and sociodemographic variables, physical disorders, and psychiatric disorders. The Singapore Mental Health Study 2016 was a population-level epidemiological survey, which determined the prevalence of physical disorders, psychiatric disorders, and suicidality. Questionnaires were used to determine socio-demographic information. A total of 6216 respondents were interviewed. Lifetime prevalence of suicidal ideation, planning, and attempts were 7.8%, 1.6%, and 1.6%, respectively. All components of suicidality were more likely in those with major depressive disorder, bipolar disorder, generalized anxiety disorder, alcohol use disorder, and chronic pain. Suicidal ideation and attempts were more likely in those with diabetes. Age above 65, being male, and a monthly household income of ≥ SGD 10,000 were associated with a lower likelihood of suicidal ideation. These findings indicate that there are high-risk groups for whom suicidality is a concern, and for whom interventions may be needed.
Psychological Impact of the Lockdown Due to the COVID-19 Pandemic in University Workers: Factors Related to Stress, Anxiety, and Depression
Authors: Salazar Alejandro , Palomo-Osuna Jenifer , de Sola Helena , Moral-Munoz Jose A. , Dueñas María , Failde Inmaculada
Published: April 2021

This study aims to explore the psychological impact of the coronavirus disease (COVID-19)-related lockdown in university workers, and to analyse the factors related to their levels of stress, anxiety, and depression. A cross-sectional study was conducted between 8–22 April 2020, 3.5 weeks after the COVID-19-related lockdown in Spain. We collected sociodemographic and occupational data, in addition to housing, work and health conditions. Coping strategies (Brief COPE-28); level of anxiety, stress, and depression (Depression Anxiety Stress Scales DASS-21); perception of the disease (COVID-19) (Brief Illness Perception Questionnaire BIPQ); and perceived level of social support (Escala Multidimensional de Apoyo Social EMAS) were measured. Multiple linear regression models were fitted to explore the factors related to the level of anxiety, depression, and stress. The sample included 677 subjects. Higher scores in depression, anxiety, and stress occurred among females, younger subjects, administration and service workers; and subjects with a smaller home, as well as those with worse health status, worse quality of sleep, and dysfunctional coping strategies. The COVID-19-related lockdown had a great impact on the mental health of university workers. The participants with specific sociodemographic and occupational characteristics, clinical disorders, and dysfunctional coping strategies were more at risk.
Pharmacist-Led Collaborative Medication Management for the Elderly with Chronic Kidney Disease and Polypharmacy
Authors: Kim A Jeong , Lee Hayeon , Shin Eun-Jeong , Cho Eun-Jung , Cho Yoon Sook , Lee Hajeong , Lee Ju-Yeun
Published: April 2021

Inappropriate polypharmacy is likely in older adults with chronic kidney disease (CKD) owing to the considerable burden of comorbidities. We aimed to describe the impact of pharmacist-led geriatric medication management service (MMS) on the quality of medication use. This retrospective descriptive study included 95 patients who received geriatric MMS in an ambulatory care clinic in a single tertiary-care teaching hospital from May 2019 to December 2019. The average age of the patients was 74.9 ± 7.3 years; 40% of them had CKD Stage 4 or 5. Medication use quality was assessed in 87 patients. After providing MMS, the total number of medications and potentially inappropriate medications (PIMs) decreased from 13.5 ± 4.3 to 10.9 ± 3.8 and 1.6 ± 1.4 to 1.0 ± 1.2 (both p < 0.001), respectively. Furthermore, the number of patients who received three or more central nervous system-active drugs and strong anticholinergic drugs decreased. Among the 354 drug-related problems identified, “missing patient documentation” was the most common, followed by “adverse effect” and “drug not indicated.” The most frequent intervention was “therapy stopped”. In conclusion, polypharmacy and PIMs were prevalent in older adults with CKD; pharmacist-led geriatric MMS improved the quality of medication use in this population.
Time Trends of Percutaneous Injuries in Hospital Nurses: Evidence of the Interference between Effects of Adoption of Safety Devices and Organizational Factors
Authors: Ferrario Marco M. , Veronesi Giovanni , Borchini Rossana , Cavicchiolo Marco , Dashi Oriana , Dalla Gasperina Daniela , Martinelli Giovanna , Gianfagna Francesco
Published: April 2021

Few studies have focused on the combined effects of devices and work organization on needlestick injuries trends. The aim of the study was to estimate trends of percutaneous injury rates (IR) in nurses (N) and nurse assistants (NA) over a 10 year period, in which passive safety devices were progressively adopted. Percutaneous and mucocutaneous injuries registered in a University Hospital in Northern Italy in Ns and NAs in 2007–2016 were analyzed. Organizational data were also available on shift schedules, turnover, downsizing and age- and skill-mix. We estimated IRs per 100 full-time equivalent workers from Poisson models and their average annual percent changes (APC) from joinpoint regression model. In the entire period, monotonic decreases in percutaneous IRs occurred among day-shift Ns (APC = −20.9%; 95% CI: −29.8%, −12%) and NAs (APC = −15.4%; −32.9%, 2.2%). Joinpoint modeling revealed a turning point in 2012 for night-shift Ns, with a steady decline in 2007–2012 (APC = −19.4%; −27.9%, −10.9%), and an increase thereafter (APC = +13.5%; 1.5%, 25.5%). In comparison to 2008 and 2012, in 2016 night-shift Ns were 5.9 and 2.5 times more likely to be younger and less qualified or experienced than day-shift Ns. The observed declines in percutaneous injury rates occurred in a time period when safety devices were progressively implemented. The causal nature of multiple exposures and organizational procedures in affecting injury time trends should be further addressed by quasi-experimental studies.
Oxytocin Administration in Low-Risk Women, a Retrospective Analysis of Birth and Neonatal Outcomes
Authors: Espada-Trespalacios Xavier , Ojeda Felipe , Perez-Botella Mercedes , Milà Villarroel Raimon , Bach Martinez Montserrat , Figuls Soler Helena , Anquela Sanz Israel , Rodríguez Coll Pablo , Escuriet Ramon
Published: April 2021

Background: In recent years, higher than the recommended rate of oxytocin use has been observed among low-risk women. This study examines the relationship between oxytocin administration and birth outcomes in women and neonates. Methods: A retrospective analysis of birth and neonatal outcomes for women who received oxytocin versus those who did not. The sample included 322 women with a low-risk pregnancy. Results: Oxytocin administration was associated with cesarean section (aOR 4.81, 95% CI: 1.80–12.81), instrumental birth (aOR 3.34, 95% CI: 1.45–7.67), episiotomy (aOR 3.79, 95% CI: 2.20–6.52) and length of the second stage (aOR 00:18, 95% CI: 00:04–00:31). In neonatal outcomes, oxytocin in labor was associated with umbilical artery pH ≤ 7.20 (OR 3.29, 95% CI: 1.33–8.14). Admission to neonatal intensive care unit (OR 0.56, 95% CI: 0.22–1.42), neonatal resuscitation (OR 1.04, 95% CI: 0.22–1.42), and Apgar score <7 (OR 0.48, 95% CI: 0.17–1.33) were not associated with oxytocin administration during labor. Conclusions: Oxytocin administration during labor for low-risk women may lead to worse birth outcomes with an increased risk of instrumental birth and cesarean, episiotomy and the use of epidural analgesia for pain relief. Neonatal results may be also worse with an increased proportion of neonates displaying an umbilical arterial pH ≤ 7.20.
Transdisciplinary Research on Indoor Environment and Health as a Social Process
Authors: Stålne Kristian , Pedersen Eja
Published: April 2021

Although issues concerning indoor environments and their interaction with humans span many disciplines, such as aerosol technology, environmental psychology, health, and building physics, they are often studied separately. This study describes a research project with the transdisciplinary aim of bridging such disciplinary boundaries. Semi-structured interviews were conducted with the twelve project members to explore their understanding of transdisciplinarity regarding the conceptual as well as social aspects of collective learning and leadership and the measures taken to achieve this. The interviews were coded in NVivo (QSR International, Doncaster, Australia), which was used to identify themes concerning notions associated with transdisciplinarity, collective leadership, collective intelligence, and learning. A shared understanding of transdisciplinarity meant that the researchers transcended their disciplinary boundaries by moving into each other’s fields. This collective learning process was facilitated by introductory lectures on each other’s fields, contributing to collective leadership and a safe atmosphere. We argue that a transdisciplinary approach is appropriate in order to address indoor environment issues as well other complex problems, for which additional time and resources should be allocated for individual and collective learning processes.
Effects of Manufacturing Variation in Electronic Cigarette Coil Resistance and Initial Pod Mass on Coil Lifetime and Aerosol Generation
Authors: Saleh Qutaiba M. , Hensel Edward C. , Eddingsaas Nathan C. , Robinson Risa J.
Published: April 2021

This work investigated the effects of manufacturing variations, including coil resistance and initial pod mass, on coil lifetime and aerosol generation of Vuse ALTO pods. Random samples of pods were used until failure (where e-liquid was consumed, and coil resistance increased to high value indicating a coil break). Initial coil resistance, initial pod mass, and e-liquid net mass ranged between 0.89 to 1.14 [Ω], 6.48 to 6.61 [g], and 1.88 to 2.00 [g] respectively. Coil lifetime was µ (mean) = 158, σ (standard deviation) = 21.5 puffs. Total mass of e-liquid consumed until coil failure was µ = 1.93, σ = 0.035 [g]. TPM yield per puff of all test pods for the first session (brand new pods) was µ = 0.0123, σ = 0.0003 [g]. Coil lifetime and TPM yield per puff were not correlated with either variation in initial coil resistance or variation in initial pod mass. The absence of e-liquid in the pod is an important factor in causing coil failure. Small bits of the degraded coil could be potentially introduced to the aerosol. This work suggests that further work is required to investigate the effect of e-liquid composition on coil lifetime and TPM yield per puff.
Obesity among Health-Care Workers: Which Occupations Are at Higher Risk of Being Obese?
Authors: Kunyahamu Muhammad Syafiq , Daud Aziah , Jusoh Nazirah
Published: April 2021

Obesity among health-care workers (HCWs) is an important issue as it can affect both their health condition and their professional capability. Although adult obesity is attributable to occupational factors, few reports are available on Malaysian health-care workers’ obesity and whether different health-care job categories are related to workers’ obesity. This study aimed to determine the prevalence of obesity among HCWs and the association between various HCW job categories and obesity. A cross-sectional study was conducted by analyzing secondary data from the 2019 annual cardiovascular health screening program, which included information regarding all government health-care workers in the east coast region of Peninsular Malaysia. The subject’s body mass index (BMI) was categorized according to WHO criteria. Only 43% of the subjects had a normal BMI, while 33.1% were categorized as overweight, and 21.1% were obese. Different HCWs’ job categories were shown to be significantly associated with their obesity status, with nurses apparently having a higher risk of being obese (Adj OR = 1.91, 95% CI 1.45, 2.53, p-value < 0.001). This study’s results require further exploration of HCWs’ working condition factors and for different job categories that contribute to obesity. Public health intervention programs to combat obesity should be implemented that primarily target HCW groups at the highest risk of obesity.