bluuebunny/crossref_metadata_2025 huggingface dataset:
Navigating the Labyrinth of Pregnancy-Related Coverage for Undocumented Immigrants: An Assessment of Current State and Federal Policies
Authors: DiMeo Amanda , Logendran Rasheca , Sommers Benjamin D. , Beecroft Alexandra , Herencia Yessamin Pazos , Bazan Maria , Wade Carrie , Sprankle Jeffrey , Sullivan Margaret M. , Molina Rose L.
Published: August 2024

Insurance coverage for prenatal care, labor and delivery care, and postpartum care for undocumented immigrants consists of a patchwork of state and federal policies, which varies widely by state. According to federal law, states must provide coverage for labor and delivery through Emergency Medicaid. Various states have additional prenatal and postpartum coverage for undocumented immigrants through policy mechanisms such as the Children’s Health Insurance Program’s “unborn child” option, expansion of Medicaid, and independent state-level mechanisms.

Using a search of state Medicaid and federal government websites, we found that 27 states and the District of Columbia provide additional coverage for prenatal care, postpartum care, or both, while 23 states do not. Twelve states include any postpartum coverage; 7 provide coverage for 12 months postpartum.

Although information regarding coverage is available publicly online, there exist many barriers to access, such as lack of transparency, lack of availability of information in multiple languages, and incorrect information. More inclusive and easily accessible policies are needed as the first step toward improving maternal health among undocumented immigrants, a population trapped in a complicated web of immigration policy and a maternal health crisis. ( Am J Public Health. 2024;114(10):1051–1060. https://doi.org/10.2105/AJPH.2024.307750 )
Countercurrent Imbibition in Porous Media with Dense and Parallel Microfractures: Numerical and Analytical Study
Authors: Yu Fei , Han Rujun , Xu Ke
Published: August 2024

Countercurrent imbibition is the process in which the wetting fluid spontaneously displaces the nonwetting fluid, while the nonwetting fluid is recovered at the wetting fluid inlet. It is a major mechanism for the recovery of shale oil, shale gas, and tight oil. In shale and tight formations, microfractures are highly developed. Specifically, some typical formations, such as continental shales, consist of dense and parallel microfractures (DPFs). In DPF systems, microfractures are segregated by low-permeability matrix layers, while the very close distance betwen neighboring microfractures results in strong capillary correlation. The underlying assumptions of the classical dual-porosity (DP) model break down. Despite extensive studies on layered media, there is still no suitable model to describe imbibition in the DPF system at the representative elementary volume (REV) scale.

In this study, we first numerically simulate countercurrent imbibition in DPF systems with fine grids, adopting typical continental shale parameters. For imbibition parallel to microfractures, two distinct stages are identified: an early stage where fractures are not correlated and a late stage where neighboring fractures are strongly correlated by capillarity. In both stages, cumulative oil production (Q) is proportional to the square root of imbibition time (t1/2), while the prefactors are very different. The late stage is the dominant stage in oil recovery. We note that the matrix permeability rarely contributes to imbibition parallel to microfractures at the late time, indicating that the matrix’s role here is to store fluid rather than to provide flow resistance. In addition, we rationalize the failure of the classical DP model, as it significantly overestimates fracture-matrix fluid exchange near the displacement front. Similarly, for imbibition perpendicular to microfractures, Q is also proportional to t1/2 in the late stage.

After elucidating the mechanisms of fracture-fracture capillary interaction, we successfully derive analytical solutions for uni-directional countercurrent imbibition kinetics in DPF systems at the late stage, for imbibition parrallel and perpendicular to microfractures, respectively. We accordingly propose an equivalent REV scale model and examine it with fine-grid simulations. We highlight the importance of adopting anisotropic relative permeability in this DPF system at REV scale for reservoir simulation rather than simply adopting anisotropic absolute permeability. This presents a new challenge for numerical simulations at reservoir scale.
Nanobody-based indirect competitive ELISA for the detection of aflatoxin M1 in dairy products
Authors: Yi Li , Liu Haiyuan , Liu Yingda , - Aiyisi , He Jing , Ming Liang , - Jirimutu
Published: August 2024

Aflatoxin M1 (AFM1) is known to be carcinogenic, mutagenic, and teratogenic and poses a serious threat to food safety and human health, which makes its surveillance critical. In this study, an indirect competitive ELISA (icELISA) based on a nanobody (Nb M4) was developed for the sensitive and rapid detection of AFM1 in dairy products. In our previous work, Nb M4 was screened from a Bactrian-camel-immunized phage-displayed library. It exhibits VH-like features, possesses higher thermal stability than monoclonal antibody (mAb 1E6) and tightly binds to AFM1–BSA with a KD value of 2.5 nM. Under the optimal conditions, its half-maximal inhibitory concentration was 0.338 ng/mL, the limit of detection was 0.051 ng/mL, and linearity was noted in the range of 0.168–0.679 ng/mL. Nb M4 displayed almost no cross-reactivity with other mycotoxins. No matrix effect was observed in milk and milk powder samples, and the matrix effect in yogurt samples could be weakened by 2-fold dilution. Furthermore, validation studies in spiked samples (milk, yogurt, and milk powder) resulted in good recoveries of 95.40%–111.33%, with a low coefficient of variation (2.89%–6.78%). High-performance liquid chromatography was used to evaluate the accuracy and reliability of the developed icELISA, which indicated a satisfactory consistent correlation (R2 = 0.9722). This study has provided a novel and ideal strategy for detecting AFM1 in dairy products.
Preclinical evaluation and preliminary clinical study of 68 Ga-NODAGA-NM-01 for PET imaging of PD-L1 expression
Authors: Zhao Lingzhou , Gong Jiali , Liao Sisi , Huang Wenhua , Zhao Jinhua , Xing Yan
Published: August 2024

Background: Programmed cell death 1/programmed death ligand-1 (PD-L1)-based immune checkpoint blockade is an effective treatment approach for non-small-cell lung cancer (NSCLC). However, immunohistochemistry does not accurately or dynamically reflect PD-L1 expression owing to its spatiotemporal heterogeneity. Herein, we assessed the feasibility of using a 68Ga-labeled anti-PD-L1 nanobody, 68Ga-NODAGA-NM-01, for PET imaging of PD-L1.
Methods: Micro-PET/CT and biodistribution studies were performed on PD-L1-positive and -negative tumor-bearing mice. Additionally, a preliminary clinical study was performed on two patients with NSCLC. NM-01 was radiolabeled with 68Ga without further purification under mild conditions.
Results: 68Ga-NODAGA-NM-01 exhibited radiochemical purity (>98%), high stability in vitro, and rapid blood clearance in vivo. Specific accumulation of 68Ga-NODAGA-NM-01 was observed in PD-L1-positive tumor-bearing mice, with a good tumor-to-background ratio 0.5 h post-injection. Furthermore, 68Ga-NODAGA-NM-01 PET/CT imaging was found to be safe with no adverse events and distinct uptake in primary and metastatic lesions of the PD-L1-positive patient, with a higher maximal standardized uptake value than that in lesions of the PD-L1-negative patient 1 h post-injection.
Conclusions: 68Ga-NODAGA-NM-01 can be prepared using a simple method under mild conditions and reflect PD-L1 expression in primary and metastatic lesions. However, our findings need to be confirmed in a large cohort.
Trial registration: NCT02978196. Registered February 15, 2018.
Research protocol on the impact of assessing the dynamic trajectory and the prediction of prognosis of HPV infection based on the spouse cohort of patients with oropharyngeal squamous cell carcinoma (SCOPE)
Authors: Zhu Yingying , Diao Wenwen , He Huijing , Zhu Xiaoli , Chen Xingming
Published: August 2024

Background: Oropharyngeal squamous cell carcinoma (OPSCC) is one of the leading cancer burdens worldwide. In China, rates of age-standardized OPSCC and mortality incidences have dramatically been increasing in recent years. Most OPSCC cases are found to be induced by human papillomavirus (HPV) through the oral-genital route during sexual activities. Dramatically increasing incidences of HPV-associated OPSCC in Chinese couples are believed to be caused by altered sexual behaviors. However, a pathophysiological understanding of the correlation between HPV infections in spouses of HPV-OPSCC patients and the impact of post-treatment HPV status on the prognosis of OPSCC is still lacking in China and requires further epidemiological evaluations and confirmatory analyses. We aim to decipher crucial etiological indicators of HPV-OPSCC by analyzing the characteristics of HPV infection in patients’ spouses through multiple cross-sectional surveys and laboratory findings for current and follow-up visits.
Methods: The spouse cohort of patients with oropharyngeal squamous cell carcinoma(SCOPE) is an open-ended bidirectional retrospective and prospective cohorts that aim to investigate the characteristics of HPV infections in spouses and their possible association with the etiological factors of HPV-OPSCC pathology through the deep analysis of long-term follow-up and laboratory data. This study proposal will adopt of more than 400 OPSCC patient-spouse pairs at Beijing Union Medical College Hospital from 2013 to date.
The primary outcome is set as overall survival (OS) and disease-specific survival (DSS), and the secondary outcome is to explore the impact of HPV infection on the reproductive health and the next generation.
Discussion: We found a correlation between HPV infection and the risk of developing OPSCC in Chinese couples. Furthermore, we compared HPV infection rates between OPSCC and non-OPSCC populations. We hypothesize that oral-genital sexual activities may play a crucial role in the pathogenesis of HPV-associated OPSCC. The absence of complete epidemiological evidence and conflicting results warrants further in-depth investigations to unveil HPV-OPSCC disease-causing factors in Chinese populations.
WITHDRAWN: No-tillage decreases GHG emissions by enhancing SOC and facilitating a stable methane-oxidizing bacterial community from an oilseed rape-rice system
Authors: Ma Mingkun , Yang Zepeng , Chen Shanghong , Liu Dinghui , Zheng Shenghua , Chen Honglin
Published: August 2024

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Body mass estimations in extinct caviomorphs (Ctenohystrica, Hystricognathi) from cheek tooth measures: importance of predictor, reference sample and method
Authors: Boivin Myriam , Álvarez Alicia , Ercoli Marcos Darío , Moyano Rocío Silvana , Salgado-Ahumada Juan Sebastián , Tejerina Agustina Mariana Ortiz , Cassini Guillermo Hernán
Published: August 2024

Caviomorph rodents present an astonishing variation in sizes both nowadays and in the past. The objective of this work was to estimate the body mass of 32 extinct caviomorphs. Moreover, we seek to analyse the influence on the estimations of the: i. selected predictors (i.e., measurements on cheek teeth); ii. used reference sample comparing three distinct datasets linked to the representativeness of sizes among herbivores; and iii. employed method constructing simple and multiple regressions, which consider phylogeny and not. The results indicated that the best dental structures to predict body mass usually were the second upper and lower molars, the upper and lower rows and first upper molar. Including ungulates improved the predictions for living large rodents, while it was not the case for the living caviomorphs and small rodents. Thus, different sets of best models were proposed depending of the size range to which belongs the extinct caviomorph considered. OLS had better performance in most cases. Multiple regressions, associating dental length and width, usually improved the mean of the prediction errors with respect to simple models. Despites a probable important redundancy between these variables, independent information would be thus sufficient to improve the error of prediction. Our estimations from dental dimensions for large and giant chinchilloids are within the range of values previously obtained using a cranial variable recently considered as a robust body size proxy. For the small extinct caviomorphs, our estimations showed more deviation with respect to the body mass values available in literature.
STING Drives Pyroptosis and Exacerbates Intestinal Ischemia-Reperfusion Injury
Authors: DING Ke , Zhang Yiguo , Zhang Lele , Liao Shishi , Weng Ziyi , Chen Rong , Meng Qingtao
Published: August 2024

This study aimed to investigate the role of STING (Stimulator of Interferon Genes) in intestinal ischemia-reperfusion (IIR) injury, focusing on its impact on mitochondrial function, pyroptosis, and intestinal inflammation. The study utilized both in vivo and in vitro models, including a mouse model of IIR and intestinal organoids subjected to hypoxia-reoxygenation (HR). We assessed the effects of pharmacological STING inhibition using H.151 and STING knockout mouse on intestinal injury markers, including histological damage, pro-inflammatory cytokine levels, mitochondrial morphology and function, and pyroptosis markers. Our findings revealed that IIR significantly upregulated STING expression in the intestinal epithelium, coinciding with increased intestinal permeability, elevated pro-inflammatory cytokine production (IL-1β) (p < 0.05), and evidence of mitochondrial dysfunction, characterized by reduced ATP production and disrupted morphology (p < 0.01). Importantly, both H.151 treatment and STING knockout significantly attenuated IIR-induced intestinal damage (p < 0.01), reduced pro-inflammatory cytokine levels (p < 0.05), and preserved mitochondrial function (p < 0.01). Furthermore, we observed a significant reduction in pyroptosis, as evidenced by decreased cleaved gasdermin D levels, in both H.151-treated and STING knockout groups (p < 0.05). This study identifies STING as a critical mediator of IIR-induced intestinal injury, likely through the activation of pathways leading to mitochondrial dysfunction and pyroptosis. Our findings suggest that targeting STING represents a promising therapeutic strategy for mitigating intestinal damage following ischemia-reperfusion.
People without clinical diagnosis of intolerance or allergy have benefits from gluten-and casein-free diet
Authors: Penaforte Nathália de Freitas , Rodrigues Marcelo Cairrão Araújo , Guedes Arildo Lemes , de Araújo Fernando Wesley Cavalcanti , Nascimento Elizabeth do
Published: August 2024

Introduction and Aim: The present study aimed to assess university professors and students regarding the variation in body mass and intestinal health resulting from a restricted dietary intervention in foods containing gluten and casein. Methods: This was a non-randomized, quasi-experimental clinical trial type study. Initially, 122 volunteers aged 20 to 55 years of both sexes were evaluated, but only 63 volunteers comprised the final sample. Participants were divided into two groups: No Gluten/Casein containing Food Restriction (CG, n= 42) and Gluten/Casein containing Food Restriction (EG, for 90 days, n= 21). Approval was obtained from the Ethics Committee on Human Research at the Health Sciences Center of the Federal University of Pernambuco under protocol number 5.671.846. It also presents the Brazilian Clinical Trials Registry (ReBEC) under number RBR-6htr5rg.
Results: Scores from the Metabolic Screening Questionnaire (MSQ) in the intervention group for the thick domain showed a significant improvement compared to the NGC. Additionally, within-group comparisons showed reduced scores in the overall MSQ and domains of the digestive tract, mind, head, and emotions (p=<0.0001; p=0.0003; p=0.0434; p=0.0143; p=0.0318; respectively). Improvement in responses to the Bristol Scale was observed after gluten-and casein-free diet (GCFD). There was no reduction in body mass or Body Mass Index (BMI).
Conclusion: These results confirm our hypothesis that GCFD seems to contribute to improve intestinal function in people without diagnosed intolerances/allergies to these components. Making it a pioneer in the outlined research design.
MYC-Mediated Inhibition of ARNT2 Uncovers a Key Tumor Suppressor in Glioblastoma
Authors: Hao Yi-Heng , Borenstein-Auerbach Nofit , Grichuk Anthony , Li Li , Lafita-Navarro M. Carmen , Fang Shun , Nogueira Pedro , Kim Jiwoong , Xu Lin , Shay Jerry W. , Conacci-Sorrell Maralice
Published: August 2024

Tumor initiation and progression rely on intricate cellular pathways that promote proliferation while suppressing differentiation, yet the importance of pathways inhibiting differentiation in cancer remains incompletely understood. Here, we reveal a novel mechanism centered on the repression of the neuronal-specific transcription factor ARNT2 by the MYC oncogene that governs the balance between proliferation and differentiation. We found that MYC coordinates the transcriptional repression of ARNT2 through the activity of polycomb repressive complex 2 (PRC2). Notably, ARNT2, highly and specifically expressed in the central nervous system, is diminished in glioblastoma, inversely correlating with patient survival. Utilizing in vitro and in vivo models, we demonstrate that ARNT2 knockout (KO) exerts no discernible effect on the in vitro proliferation of glioblastoma cells, but significantly enhances the growth of glioblastoma cells in vivo. Conversely, ARNT2 overexpression severely dampens the growth of fully transformed glioblastoma cells subcutaneously or orthotopically xenografted in mice. Mechanistically, ARNT2 depletion diminishes differentiation and enhances stemness of glioblastoma cells. Our findings provide new insights into the complex mechanisms used by oncogenes to limit differentiation in cancer cells and define ARNT2 as a tumor suppressor in glioblastoma.
Effect of Transcranial Alternating Current Stimulation on Ataxia Symptoms of Spinocerebellar Ataxia Type 3: A Randomized Clinical Trial
Authors: Shirui Gan , Xia Liu , Wei Lin , Huating Zeng , Liangliang Qiu , Xiaoping Cheng , Wanli Zhang , Yanhua Lian , Yingjuan Zhang , Zhaodi Wang , Xichen Wang , Ruying Yuan , Xuanyu Chen , Zhixian Ye , Yue Zhang , Wang Duolao , Jun Ni , Wang Ning , Fu Ying , Chen Xin-Yuan , Qikui Sun , Shuna Huang
Published: August 2024

Currently, there are no treatments to alter the natural course of spinocerebellar ataxia type 3 (SCA3). Transcranial alternating current stimulation (tACS) have the sustainable potential to alleviate SCA3. Therefore, we conducted a randomized controlled trial enrolling 158 patients with SCA3 to investigate the safety and efficacy of tACS (NCT05557786). Enrolled participants received Active-tACS or Sham-tACS treatment 5 days/week for 2 weeks. The primary outcome was the proportion of participants whose Scale for the Assessment and Rating of Ataxia score improved by at least 1.5 points compared with baseline on assessments immediately after treatment and at 1-month and 3-month follow-up visits. The primary outcome assessed in the intention-to-treat population was met by 32 of 40 patients in the active-tACS group (80%) and 4 of 40 patients in the sham-tACS group (OR, 2.04[95% CI, 1.75 to 2.38; P < 0.001]). These promising findings motivate additional study to establish guidelines for tACS as a clinically recommended treatment for cerebellar diseases.
Outcomes of Vacuum Assisted Closure versus Conventional Dressings in patients with Diabetic Foot Ulcers
Authors: Ranjan Piyush , . Rishika , Mondal Saptarshi
Published: August 2024

Introduction: To compare the effectiveness of Vacuum Assisted Closure (VAC) dressing over Conventional Dressing in case of Diabetic Foot Ulcers. In view of this, the present study was planned to weigh between Vacuum Assisted Closure (VAC) and the conventional dressing methods in case of Diabetic Foot Ulcer in factors like rate of granulation tissue formation, Bacterial clearance in the end of the therapy and duration of wound healing. Patients and Methods: This was a randomized comparative study conducted in the department of General Surgery, Indira Gandhi Institute of Medical Sciences, Patna from January 21 to December 22.50 patients with lower limb diabetic ulcers were included who were randomized into two groups-Conventional Dressing was done(n = 31); Vacuum Assisted Closure (VAC) dressing was done(n = 19). Patients were compared for outcomes after dressing. Statistical Analysis was done by SPSS software and P value < 0.05 were considered statistically significant. Result: Compared to Conventional Dressing,Vacuum Assisted Closure (VAC) Dressing group had comparable age,gender and associated comorbidities (p value > 0.05), took less but comparable duration for granulation tissue to appear (6.94SD2.61 vs. 9.03SD2.30, p value-0.29) took significantly lesser duration for wound culture to be negative (11.36SD4.47 vs. 14.83SD3.89, p value-0.037), took significantly lesser duration for wound healing (36.84SD9.34 vs. 43.16SD9.22, p value-0.033). Conclusion: Vacuum Assisted Closure (VAC) dressing was advantageous over Conventional Dressing for Dressing of lower limb diabetic ulcers in terms of time taken for formation of granulation tissue, time taken for wound culture to be negative and on long term follow ups, also in duration of healing of wounds.Vacuum Assisted Closure (VAC) dressing for chronic wounds or ulcers seemed to be a promising option to conventional dressing and the short-term results were good.
Exploring Extracurricular Activities in Bangladesh: Access, Gender Disparities, and Shifts in Online Engagement
Authors: Jubair Hassan , Mehenaz Mithela
Published: August 2024

This study investigates the accessibility, gender disparities, and preferences related to extracurricular activities (ECAs) among students in Bangladesh. Utilizing a survey conducted with middle school, high school, and undergraduate students, we explore the challenges faced by urban versus rural students, the specific barriers encountered by female students, and the preferences for online versus offline ECAs. The results reveal significant disparities, with rural students and female participants facing considerable obstacles in accessing ECA opportunities. A strong preference for online ECAs is evident, although awareness of existing platforms facilitating ECA opportunities is limited. The findings highlight the need for targeted interventions to improve ECA accessibility, promote gender equality, and enhance the visibility of ECA resources. This study provides actionable recommendations to foster a more inclusive environment for ECA participation, ultimately contributing to the holistic development of students across Bangladesh.
Study on influencing factors of medication adherence to inhalers in patients with COPD and asthma based on Anderson Model
Authors: Yin Chengchen , Luo Yongyong , Shen Kaili , Mao Guangxin , Tang Fushan
Published: August 2024

Purpose
To investigate the influencing factors of adherence to inhalers in patients with COPD and asthma, providing reference for improving the adherence to inhalers of patients with asthma and COPD.
Methods
A questionnaire was designed based on Anderson's model, and used to investigate the influencing factors of adherence to inhalers in COPD or asthma patients who were discharged inpatients or outpatients and had previously been prescribed inhalers in the respiratory departments of three tertiary hospitals in Zunyi City.
Results
Only 25.90% of patients demonstrate good adherence to inhalers. When combined with the Anderson model, the influencing factors of inhaler adherence in COPD and asthma patients can be summarized as follows: contextual characteristics (residential status, management of chronic illness cards), individual characteristics (disease condition, family history, medication beliefs) and outcomes (health status).
Conclusion
The medication adherence to inhalers in patients with COPD and asthma falls far short of being satisfactory. Pharmacists should collaborate with physician, nurses, communities, and patients' families, to proactively implement interventions targeting influencing factors of medication adherence to inhalers in patients with COPD and asthma. This will help improve patients' adherence to inhalers and, subsequently, enhance their quality of life.
Denosumab combined with en bloc resection and arthrodesis for recurrent grade 3 giant cell tumor of bone in distal radius
Authors: Li Zhuoyu
Published: August 2024

Purpose
This study aimed to analyse the clinical outcomes of preoperative adjuvant denosumab therapy (PADT) combined with resection and arthrodesis for recurrent grade 3 giant cell tumor of bone (GCTB) in the distal radius.
Methods
A retrospective study was conducted on twenty-three patients (8 males, 15 females) who were treated with the adjuvant denosumab combined with en bloc resection (EBR) and arthrodesis for biopsy confirmed recurrent Campanacci III giant cell tumor of bone in the distal radius between January 2015 and December 2022. All 23 patients were treated with wrist arthrodesis reconstruction using autogenous free iliac crest bone graft (ICBG), bridging plate and screws. The local control, metastasis and overall survival were evaluated during the follow-up period. Functional outcomes were evaluated using the Disabilities of the Arm, Shoulder and Hand (DASH) score, Musculoskeletal Tumor Society Score (MSTS-87 and MSTS-93), and grip strength in the follow-up period. Additionally, all surgical or denosumab-related complications that occurred were recorded in this study.
Results
Twenty-three patients were included in this retrospective study and no patients were lost in the follow-up period. The average patient age was 32.5 ± 10.2 years (range, 19–53 years) and the mean follow-up time was 35.5 ± 18.4 months (range, 13–72 months). The average tumor length was 71.7 ± 8.7 mm (range, 50 to 85 mm) and bone reconstruction length was 78.5 ± 8.5 mm (range, 60 to 90 mm). Four patients (17.4%) had secondary local recurrence after reoperation and two patients had (8.7%) multiple recurrences. One patient (4.3%) was deceased in the last follow-up due to multiple metastases. The estimated 5-year recurrence-free survival rate was 81.3% and 5-year metastasis-free survival rate was 95.7%. The mean union time was 8.5 ± 1.9 (6–12) months and the overall survivorship of the allograft was 82.7% (21/23) at an average 35 month follow-up. The average MSTS-87 and MSTS-93 scores were 27.8 ± 1.6 (range, from 23 to 30) and 91.5 ± 5.0 (range, from 76 to 100), and the average DASH score was 8.9 ± 3.2 (range, from 3 to 15), respectively. The average grip strength was 64.6 ± 15.7% (range, from 30–95%) of the uninvolved side. Eight patients (34.7%) had at least one complication in the follow-up time. Two autografts (8.7%) were removed due to local recurrence and bone nonunion, and the average autograft survival time was 32.8 ± 18.5 months (range, 12 to 72 months).
Conclusions
Preoperative adjuvant denosumab therapy (PADT) combined with en bloc resection and arthrodesis is a promising method for the treatment of recurrent Campanacci III GCTB in distal radius with acceptable short-term local control and functional satisfaction.
Level of evidence
level IV Therapeutic.
The future bioenergy plant portfolio in the German power sector: scenarios for different framework conditions
Authors: Dotzauer Martin , Schindler Harry , Daniel-Gromke Jaqueline , Thraen Daniela
Published: August 2024

Bioenergy plays a crucial role in Germany’s renewable energy supply of 513 TWh in 2023. It contributes 254 TWh for heating, fuels, and electricity. The German Renewable Energy Sources Act (EEG) guarantees feed-in tariffs for electricity for 20 years. For many bioenergy plants, the feed-in tariff will expire in the coming years. The latest EEG of 2023 offers tenders, which are also open to existing plants to extend their operation for 10 years, but with lower subsidies. The fuel and heating markets also offer business opportunities that influence the portfolio dynamics of the German power sector.
We use an agent-based modelling approach to investigate the future development of the bioenergy plant portfolio under scenarios for different framework conditions. These include a number of business‑as‑usual cases, as well as 5 additional scenarios for the assessment of different policy measures.
We find that the current bioenergy portfolio in the German power sector cannot be maintained under the current framework conditions. Depending on the scenario, installed capacity will decline by between one third and one eight. Without appropriate adjustments, e.g. higher tender volumes, and 20 instead of 10 extended years of operation, Germany cannot reach its bioenergy target of 8.4 GW in 2030.
Nutrition Security Status of Women in Northwest Ethiopia
Authors: Teshome Fentaw , Andaregie Adino , Astatkie Tessema
Published: August 2024

Background: Nutrition security of women is one of the most vital foundations for the overall
development and wellbeing of society. Since understanding the factors that influence the nutrition
security of women is very important for implementing appropriate interventions, this study was
conducted to determine the nutrition security status of women in Northwest Ethiopia.
Methods: Survey data were collected from 197 rural women selected using a two- stage sampling
method (Cluster sampling in the first stage and Stratified random sampling in the second stage).
Data in the two outcomes (nutritionally secured whose BMI ≥ 18.5, and nutritionally insecure
whose BMI < 18.5 kg/m2) were analyzed using a Logit regression model to determine the
significance of the determinants on women’s nutrition security status.
Results: The study showed that 72.6% of the women in the study area were nutritionally insecure.
Results of the statistical analysis revealed that family size (negative effect); and the consumption
of milk, women’s daily feed frequency, fruits and vegetables, women empowerment, and animal
products have positive effect. The height, weight, and BMI of nutritionally secure women (50.8
kg, 1.55 m, and 21.1 kg/m2, respectively) were significantly higher than those of nutritionally
insecure women (44 kg, 1.45 m, and 15.8 kg/m2, respectively).
Conclusions: This is the first study on the determinants of rural women’s nutrition security status
using social and demographic data collected at the grassroots level and analyzed using an advanced
econometric model. The findings of the study show the need for government and other
stakeholders’ interventions to increase access to nutritious food products and to provide trainings
on feeding culture and dietary diversity to women. The findings of this study can help the
Government of Ethiopia to achieve its National Development Priorities.
Quantum robustness of the toric code in a parallel field on the honeycomb and triangular lattice
Authors: Kott Viktor , Mühlhauser Matthias , Koziol Jan Alexander , Schmidt Kai Phillip
Published: August 2024

We investigate the quantum robustness of the topological order in the toric code on the honeycomb lattice in the presence of a uniform parallel field. For a field in zz-direction, the low-energy physics is in the flux-free sector and can be mapped to the transverse-field Ising model on the honeycomb lattice. One finds a second-order quantum phase transition in the 3D Ising^\star⋆ universality class for both signs of the field. The same is true for a postive field in xx-direction where an analogue mapping in the charge-free sector yields a ferromagnetic transverse-field Ising model on the triangular lattice and the phase transition is still 3D Ising^\star⋆. In contrast, for negative xx-field, the charge-free sector is mapped to the highly frustrated antiferromagnetic transverse-field Ising model on the triangular lattice which is known to host a quantum phase transition in the 3D XY^\star⋆ universality class. Further, the charge-free sector does not always contain the low-energy physics for negative xx-fields and a first-order phase transition to the polarized phase in the charge-full sector takes place at larger negative field values. We quantify the location of this transition by comparing quantum Monte Carlo simulations and high-field series expansions. The full extension of the topological phase in the presence of xx- and zz-fields is determined by perturbative linked-cluster expansions using a full graph decomposition. Extrapolating the high-order series of the charge and the flux gap allows to estimate critical exponents of the gap closing. This analysis indicates that the topological order breaks down by critical lines of 3D Ising^\star⋆ and 3D XY^\star⋆ type with interesting potential multi-critical crossing points. All findings for the toric code on the honeycomb lattice can be transferred exactly to the toric code on the triangular lattice.
Infecção e fatores associados em crianças e adolescentes em tratamento quimioterápico antineoplásico
Authors: Lucena Débora de Souza , Ramos Thaynara Tavares Oliveira , De Almeida Gabriele Cassiano , Ludgério Muanna Jéssica Batista , Dos Santos Sheila Milena Pessoa , Fernandes Juliana Andreia de Souza
Published: August 2024

Objetivo: Avaliar a prevalência de infecção em crianças e adolescentes com câncer em tratamento quimioterápico e os fatores associados. Métodos: Estudo transversal, realizado com 59 prontuários de crianças e adolescentes com câncer em tratamento quimioterápico, da ala de oncologia pediátrica no serviço de referência, em Campina Grande, Paraíba. Foi realizada análise descritiva e multivariada com regressão de Poisson. Resultados: Identificou-se uma prevalência da infecção de 47,5% durante o primeiro ciclo do tratamento quimioterápico em crianças e adolescentes com câncer. As variáveis identificadas que apresentaram significância estatística para a ocorrência da infecção foram os fatores de risco, como ventilação invasiva, ventilação não invasiva, uso de corticoides, e os sinais e sintomas, como diarreia, ruídos adventícios, dispneia, cefaleia, alteração do estado mental e comportamental, febre, taquipneia, hepatomegalia e esplenomegalia. Conclusão: Foi encontrada uma alta prevalência de infecção durante o primeiro ciclo do tratamento quimioterápico. Esta intercorrência pode retardar o tratamento oncológico, favorecer o crescimento tumoral e diminuir a efetividade da terapêutica empregada.
Marcas da matemática escolar: A experiência narrada por estudantes de pedagogia em um contexto formativo
Authors: Ciríaco Klinger Teodoro , Silva Danielle Abreu , Santino Fernando Schlindwein
Published: August 2024

Compartilhamos uma pesquisa exploratória com um grupo de, aproximadamente, 66 estudantes de Pedagogia sobre experiências com a Matemática na Educação Básica. Os dados referem-se a uma tarefa intitulada "Eu e a Matemática", desenvolvida junto à disciplina obrigatória "Matemática: Conteúdos e seu Ensino", ofertada no 6º período em 2022.2. Objetivamos identificar memórias de futuros(as) professores(as) compartilhadas no processo formativo e como estas interferem na percepção que têm da disciplina. A narrativa constituiu-se como método central para produção de dados e prática de formação. Há um consenso de que a disciplina representa "filtro" de retenção dos sujeitos, dado que pode fortalecer atitudes negativas e distanciamentos que contribuem para a constituição de alguns mitos.
Rheological and Textural Characteristics of Functional Breads Fortified with Different Eggshell Powders
Authors: Adal Samiye , Savlak Nazlı
Published: August 2024

This study explores the rheologic, textural, and sensory characteristics of bread that has been fortified with eggshell powder (ESP) obtained from various dietary and growing conditions (industrial, organic, free range, and village). The fortification of ESP led to a reduction in water absorbtion capacity, stability, softening degree, maximum resistance, energy, and resistance to extension, while the value of extensibility increased. The highest water absorption value was observed in bread flour with a percentage of 61.9, whereas among breads with ESP fortification, the highest water absorption value was 61.2% in S1 (23.5 g) and S2 (30 g) village ESP-added flours. Only the extensibility value increased when ESP was added, but the effects on water absorption, stability, softening degree, maximum resistance, energy, and resistance to extension declined. The addition of ESP results in significant changes in chewiness, springiness, resilience, and cohesiveness (p≤0.05), but the gumminess value is found to be insignificant (p≥0.05). Through sensory evaluation, all bread samples received scores of 3.77–4.46 on a 5-point scale. The rheological, textural and sensory analyses results obtained from the control and fortified bread samples demonstrated that the inclusion of calcium from egg shell powder improved the structural properties of the flour. In addition, the utilization of eggshell powder at its maximum concentration (30 g) did not yield any detrimental consequences for the dough or the bread production process. Based on a comprehensive analysis, it is concluded that including ESP in bread is an appropriate strategy for dealing with calcium deficiency and is in line with consumer acceptability and bread production technology.
Estimation in α-Series Processes with Exponential Inter-Arrival Times under Censored Data
Authors: Altındağ Ömer , Kara Mahmut , Aydoğdu Halil
Published: August 2024

The α-series process is an important counting process commonly used to model data sets having monotonic trend. It is especially utilized in reliability analysis of deteriorating systems and warranty analysis of repairable systems. When a data set is compatible with the α-series process, it is important to make inference for model parameters of the process. All the studies in the literature only consider single realization of the process which only has complete samples. However, multi-sample of the process may be observed. In this situation, the data set includes both complete and censored samples. In this study, estimation problem for an α-series process under censored data is studied by assuming inter-arrival times of the process have exponential distribution and all samples are homogeneous. Maximum likelihood estimators of the model parameters are obtained and their asymptotic properties such as asymptotic normality and consistency are proved. Also, their small sample performances have been investigated by a simulation study.
Konuşmacıları Kadın, Erkek ve Çocuk Olarak Sınıflandırmada Veri Artırmanın Performansa Etkisi
Authors: Yücesoy Ergün
Published: August 2024

Derin öğrenme alanındaki gelişmeler daha doğru sınıflandırıcıların oluşturulmasına olanak sağlamıştır. Ancak yüksek genelleme yeteneğine sahip derin öğrenme modellerinin oluşturulabilmesi için büyük miktarda etiketli veri kümelerine ihtiyaç duyulmaktadır. Veri artırma bu ihtiyacın karşılanmasında yaygın olarak kullanılan bir yöntemdir. Bu çalışmada konuşmacıların yaş ve cinsiyetlerine göre sınıflandırılmasında farklı veri artırma yöntemlerinin sınıflandırma performansı üzerindeki etkileri araştırılmıştır. Çalışmada yetişkin konuşmacılar erkek ve kadın olarak, çocuklar ise cinsiyet ayrımı yapılmadan tek bir sınıf olarak değerlendirilmiş ve toplamda üç (kadın, erkek ve çocuk) sınıflı bir sınıflandırma gerçekleştirilmiştir. Bu amaç doğrultusunda gürültü ekleme, zaman uzatma ve perde kaydırma olmak üzere üç veri artırma yöntemi farklı kombinasyonlarda kullanılarak yedi farklı model oluşturulmuş ve her birinin performans ölçümleri yapılmıştır. aGender veri kümesinden rastgele seçilen 5760 konuşma verisi ile geliştirilen bu modeller arasında en yüksek performans artışı üç veri artırma yönteminin birlikte kullanıldığı modelle sağlanmıştır. Bu model sınıflandırma doğruluğunu %84.583’den % 87.523’e çıkararak %3’e yakın performans artışı sağlarken veri artırmanın kullanıldığı diğer modellerde de %1 ile %2.3 arasında performans artışı sağlanmıştır.
Regional Imbalances in Dairy Product Availability: Price-Forming Factors
Authors: Mayorova Elena , Abramov Egor
Published: August 2024

The authors used machine learning models to analyze the regional differences in the availability of milk and dairy products. The regional imbalances appeared to be closely related to the level of income and the volume of ready-to-drink milk production in the region. These factors especially affected top-of-the-range products. Other factors included the size of the urban population, the level of milk consumption, and the milk yield per cow. The number of dairy farms, the volume of raw milk production, the size of the rural population, and the number of cows had little or no effect on the regional price policy. The results obtained may help retail trade entities, e.g., chain stores, to develop their price policy. In addition, they may assist the government in determining the areas of support for agricultural producers in order to make dairy products more available in certain regions.
Developing Production of Specialized Dairy Foods in Russia
Authors: Novokshanova Alla
Published: August 2024

Like in many other developed countries, Russian population is facing a gap between the actual diet and the nutritional needs. As a result, nutrition-related diseases are growing more wide-spread. Specialized foods reduce the consequences of poor nutrition and prevent nutritionrelated diseases. However, Russia lags behind other countries in this sphere and has to import specialized foods, which threatens its food security. Dairy products are an excellent source of animal protein, calcium, phosphorus, vitamins, and other biologically active substances. For the past three decades, Russian diet has remained below the values for dairy products recommended by the Ministry of Health. The present research objective was to assess the state of innovative dairy market in the Russian Federation using the method of expert assessment in terms of classification, composition, and producer in the Eurasian Economic Region. In March 2024, the total number of certified specialized dairy foods was 7,422 units. Dry foods predominated, e.g., powders, jellies, smoothies, cocoa, tea drinks, cocktails, puree soups, cereals, candies, bars, etc. The share of specialized dairy products in the total volume of functional foods was 0.97%, which is too low to raise the public interest to dairy products and stimulate the dairy industry as a whole. Cooperation with scientific and expert organizations will make it possible to scale up the production of specialized dairy products using the equipment available to most dairy processing enterprises.
Criteria for evaluating the antioxidant properties of secondary plant metabolites in the fortification of dairy products
Authors: Le Violetta , Prosekov Alexander , Sukhikh Andrey , Milentyeva Irina , Yustratov Vladimir
Published: August 2024

Functional products containing natural antioxidants contribute to the improvement of human health indicators, and thus contribute to an increase in life expectancy. Milk is a valuable solubilizer that promotes the dissolution of insoluble substances in a liquid. The paper presents the results of a study under conditions of high-performance liquid chromatography (HPLC) with amperometric detection of antioxidant properties of secondary plant metabolites for the enrichment of dairy products. The objects of the study were biologically active compounds isolated from extracts of callus cultures of plants grown in vitro on liquid nutrient media. The use of HPLC chromatography with an amperometric glass-carbon detector to analyze the antioxidant properties of biologically active substances of plant origin made it possible to identify the following substances from 8 types of individual compounds with a pronounced potential for biological activity: rutin, rosemary acid from Pulmonaria officinalis, trans-cinnamic acid from Scutellaria baicalensis, rutin from Filipéndula ulmária. These compounds are able to effectively inhibit free radical processes in dairy products. The use of high-performance liquid chromatography with amperometric detection can be used as a criterion for evaluating the antioxidant properties of biologically active substances isolated from extracts of callus cultures.
Modern Trends and Prospects in New Low-Lactose and Lactose-Free Products
Authors: Nikitina Yulia , Topnikova E.
Published: August 2024

The last decade has seen a wave of scientific and commercial interest in low-lactose and lactose-free dairy products. It happens because consumers are becoming increasingly more aware of various scientific achievements that make it possible to improve the quality of life. However, lactase deficiency requires an alternative to food additives. Currently, low-lactose and lactose-free products are available on the market but their volumes and range are not enough to cover the needs and meet the expectations of the target audience. This article describes various issues related to lactose-free and low-lactose dairy products, as well as assesses the range of currently available offers in this market segment and identifies the areas of potential development. Russian and foreign publications on lactose-free and low-lactose products are getting more numerous. The review outlines the most popular research areas in this respect. Low-lactose and lactose-free dairy production involves a number of reliable technologies, but the range of these products needs to be expended, i.e., based on dairy products with initially low mass fraction of lactose.
Paradigma cognitivo da ciência da informação e a construção de conhecimento
Authors: Fernandes dos Santos Rogo Gysele , Pomin Valentim Marta Lígia
Published: August 2024

A partir do referencial teórico de Rafael Capurro relacionado ao campo científico da Ciência da Informação, em que enfoca três paradigmas epistemológicos, o físico, o cognitivo e o social, cujas características são distintas, mas ao mesmo tempo possuem intersecções e complementariedades. O presente estudo tem como objetivo entender o complexo fenômeno da informação e os conceitos atribuídos no âmbito da Ciência da Informação, mais especificamente no que tange ao paradigma cognitivo, visando compreender a importância do usuário como sujeito cognoscente dos processos informacionais. Pretende-se discutir a partir do viés cognitivo, a relevância e a contribuição desta abordagem para o campo da Ciência da Informação. Este estudo foi desenvolvido a partir de uma revisão bibliográfica da literatura especializada do campo da Ciência da Informação, por meio da seleção e análise de artigos científicos. Observou-se que o conceito de informação adquire peculiaridades de acordo com o enfoque utilizado. No que tange ao usuário verificou-se que este passa a ser visto como um sujeito cognoscente ativo no decurso do processo de busca e uso da informação para a execução de atividades ou para a solução de problemas. Conclui-se que a informação na perspectiva do sujeito cognoscente deve considerar a relevância das condicionantes sociais inerentes a informação e seu contexto, ou seja, a interação do usuário com o ambiente social e/ou organizacional na qual está inserido.