bluuebunny/crossref_metadata_2025 huggingface dataset:
Capillary Flows of Nematic Liquid Crystal
Authors: Shmeliova Dina V. , Pasechnik Sergey V. , Kharlamov Semen S. , Zakharov Alexandre V. , Pozhidaev Eugeny P. , Barbashov Vadim A. , Tkachenko Timofey P.
Published: November 2020

In this paper we report the new experimental results on the rise of a liquid crystal in flat capillaries with inner photosensitive surfaces. The capillaries with different surface orientations were prepared by the use of the photo-alignment technique. Such a surface treatment makes it possible to eliminate the noncontrollable influence of a nanorelief on the wetting process, which takes place in the rubbing treatment technique previously used in similar experiments. The dynamics of the capillary rise of a nematic liquid crystal 5CB (4-cyano-4′-pentylbiphenyl) in vertical plane capillaries with photo-aligned substrates were studied for the first time. It was found that the stationary value of a contact angle weakly depends on the direction of a planar surface orientation relative to the direction of a capillary rise. It has been shown that the application of strong electric fields resulted in a decreasing of the contact angle. The results, obtained for the nematic liquid crystal, are compared with the results of an investigation of the capillary flow in a shock-free ferroelectric smectic phase.
Structural Transformations in Crystals Induced by Radiation and Pressure. Part 10. The Crystallographic Picture of Photochemical Behaviour of bi(anthracene-9,10-dimethylene) under High Pressure
Authors: Bąkowicz Julia , Turowska-Tyrk Ilona
Published: November 2020

The results of the monitoring of the [4 + 4] photocycloaddition reaction path in single crystals of bi(anthracene-9,10-dimethylene) at high pressure are presented. The crystal structures for several steps of the phototransformation at 0.3 GPa and 1.0 GPa were determined and analysed. The applied high pressure did not halt the photochemical reaction and almost 100% of the product molecules were obtained, although the reaction was very slowly reversible similarly to that of ambient conditions. During the crystal phototransformation the intramolecular geometry, molecular orientation and intermolecular interactions of the reactant changed more and more towards the values observed for the product. The initial increase in the unit cell volume brought about by the photochemical reaction was diminished by high pressure. High pressure itself did not significantly influence the intramolecular geometry of the reactant and product molecules, but it influenced the intermolecular interactions.
Being Well-Connected Pays in a Disturbed World: Enhanced Herbivory in Better-Linked Habitats
Authors: Jinks Kristin I. , Brown Christopher J. , Schlacher Thomas A. , Olds Andrew D. , Engelhard Sarah L. , Pearson Ryan M. , Connolly Rod M.
Published: November 2020

Seascapes are typically comprised of multiple components that are functionally linked by the movement of organisms and fluxes of matter. Changes to the number and spatial arrangement of these linkages affect biological connectivity that, in turn, can alter ecological functions. Herbivory is one such function, pivotal in controlling excessive algal growth when systems become disturbed. Here, we used microcosm experiments to test how the change to connectivity affects herbivory under different levels of disturbance. We applied network theory to measure types of connectivity at different scales (patch and whole system) and quantified herbivory by a crustacean mesograzer exposed to excess algae, mimicking pulse and press disturbances. We demonstrate that greater connectivity significantly enhances herbivory in Clibanarius virescens: Both the number of linkages and their spatial arrangement interact to shape the response of herbivory in systems to disturbance. Our findings highlight the value of controlled experiments for advancing theories about the potential effects of connectivity on important ecological functions, such as herbivory, and justify further investigation to measure how connectivity might affect the resilience of ecosystems. We posit that the variation in the type, and scale, of spatial linkages might have profound consequences for managing the capacity of ecosystems to respond to disturbance.
Prognostic Impact of Parameters of Metabolic Acidosis in Critically Ill Children with Acute Kidney Injury: A Retrospective Observational Analysis Using the PIC Database
Authors: Morooka Hikaru , Kasugai Daisuke , Tanaka Akihito , Ozaki Masayuki , Numaguchi Atsushi , Maruyama Shoichi
Published: November 2020

Acute kidney injury (AKI) is a major complication of sepsis that induces acid-base imbalances. While creatinine levels are the only indicator for assessing the prognosis of AKI, prognostic importance of metabolic acidosis is unknown. We conducted a retrospective observational study by analyzing a large China-based pediatric critical care database from 2010 to 2018. Participants were critically ill children with AKI admitted to intensive care units (ICUs). The study included 1505 children admitted to ICUs with AKI, including 827 males and 678 females. The median age at ICU admission was 22 months (interquartile range 7–65). After a median follow-up of 10.87 days, 4.3% (65 patients) died. After adjusting for confounding factors, hyperlactatemia, low pH, and low bicarbonate levels were independently associated with 28-day mortality (respective odds ratio: 3.06, 2.77, 2.09; p values: <0.01, <0.01, <0.01). The infection had no interaction with the three parameters. The AKI stage negatively interacted with bicarbonate and pH but not lactate. The current study shows that among children with AKI, hyperlactatemia, low pH, and hypobicarbonatemia are associated with 28-day mortality.
Hypo-Expression of Flice-Inhibitory Protein and Activation of the Caspase-8 Apoptotic Pathways in the Death-Inducing Signaling Complex Due to Ischemia Induced by the Compression of the Asphyxiogenic Tool on the Skin in Hanging Cases
Authors: Maiese Aniello , De Matteis Alessandra , Bolino Giorgio , Turillazzi Emanuela , Frati Paola , Fineschi Vittorio
Published: November 2020

The FLICE-inhibitory protein (c-FLIPL) (55 kDa) is expressed in numerous tissues and most abundantly in the kidney, skeletal muscles and heart. The c-FLIPL has a region of homology with caspase-8 at the carboxy-terminal end which allows the molecule to assume a tertiary structure similar to that of caspases-8 and -10. Consequently, c-FLIPL acts as a negative inhibitor of caspase-8, preventing the processing and subsequent release of the pro-apoptotic molecule active form. The c-FLIP plays as an inhibitor of apoptosis induced by a variety of agents, such as tumor necrosis factor (TNF), T cell receptor (TCR), TNF-related apoptosis inducing ligand (TRAIL), Fas and death receptor (DR). Increased expression of c-FLIP has been found in many human malignancies and shown to be involved in resistance to CD95/Fas and TRAIL receptor-induced apoptosis. We wanted to verify an investigative protocol using FLIP to make a differential diagnosis between skin sulcus with vitality or non-vital skin sulcus in hanged subjects and those undergoing simulated hanging (suspension of the victim after murder). The study group consisted of 21 cases who died from suicidal hanging. The control group consisted of traumatic or natural deaths, while a third group consisted of simulated hanging cases. The reactions to the Anti-FLIP Antibody (Abcam clone-8421) was scored for each section with a semi-quantitative method by means of microscopic observation carried out with confocal microscopy and three-dimensional reconstruction. The results obtained allow us to state that the skin reaction to the FLIP is extremely clear and precise, allowing a diagnosis of unequivocal vitality and a very objective differentiation with the post-mortal skin sulcus.
Metal Ion Release, Clinical and Radiological Outcomes in Large Diameter Metal-on-Metal Total Hip Arthroplasty at Long-Term Follow-Up
Authors: Pozzuoli Assunta , Berizzi Antonio , Crimì Alberto , Belluzzi Elisa , Frigo Anna Chiara , Conti Giorgio De , Nicolli Annamaria , Trevisan Andrea , Biz Carlo , Ruggieri Pietro
Published: November 2020

Total hip arthroplasty (THA) with metal-on-metal (MoM) bearings have shown problems of biocompatibility linked to metal ion release at the local level causing an adverse reaction to metal debris (ARMD) and at a systemic level. The aim of this study was to evaluate clinical and radiological outcomes, and metal ion concentrations in the blood and urine of patients who underwent THA with the LIMA Met-Met hip system. Patients with ceramic-on-ceramic (CoC) bearings were included as a control group. In this study, 68 patients were enrolled: 34 with MoM THAs and 34 with CoC THAs. Patients were evaluated clinically (Harris Hip Score, SF-36) and radiologically at a median of 7.4 years after surgery. Whole blood and urinary cobalt and chromium levels were also assessed. Both types of implants were comparable in terms of clinical and functional results. Ion levels were significantly higher in the MoM group compared with CoC group 7 years after surgery. No correlations were found between metal ion levels and patient demographics, functional and radiological outcomes, and prosthesis features. Patient monitoring is thus advised to establish if prosthesis revision is necessary, especially in the case of MoM THA.
Distributed Genetic Algorithms for Low-Power, Low-Cost and Small-Sized Memory Devices
Authors: Medeiros Denis R. da S. , Fernandes Marcelo A. C.
Published: November 2020

This work presents a strategy to implement a distributed form of genetic algorithm (GA) on low power, low cost, and small-sized memory aiming for increased performance and reduction of energy consumption when compared to standalone GAs. This strategy focuses on making a distributed version of GA feasible to run as a low cost and a low power consumption embedded system utilizing devices such as 8-bit microcontrollers (µCs) and Serial Peripheral Interface (SPI) for data transmission between those devices. Details about how the distributed GA was designed from a previous standalone implementation made by the authors and how the project is structured are presented. Furthermore, this work investigates the implementation limitations and shows results about its proper operation, most of them collected with the Hardware-In-Loop (HIL) technique, and resource consumption such as memory and processing time. Finally, some scenarios are analyzed to identify where this distributed version can be utilized and how it is compared to the single-node standalone implementation in terms of performance and energy consumption.
Analysis of Cross-Connected Half-Bridges Multilevel Inverter for STATCOM Application
Authors: Li Yuan , Humayun Muhammad
Published: November 2020

This paper suggested a single-phase cross-connected half-bridges multilevel inverter (cchb-mli) topology for static synchronous compensator (statcom) applications. The proposed mli structure consists of cross-connected multilevel cells connected in series with a more optimized number of devices to synthesize a higher number of voltage steps. Each cell in the structure consists of a set of switches and a dc-capacitor. Typically, when several dc-capacitors are used in an inverter, the dc voltages fluctuation occurs due to tolerance between passive element and asymmetric switch losses. A dual-loop control technique has been proposed with level-shifted pulse width modulation pwm to overcome these issues. The proposed methodology balances the dc-voltages using a proportional-integral controller by adjusting the switch duty cycle. The control method helps offset the issue of aggravated fluctuation while preserving the delivered reactive power distributed equally among the dc-capacitors at the same time. A thorough comparison is made between the proposed inverter concerning the number of components and efficiency to demonstrate the effectiveness of previous topologies. Moreover, a simulation model built in simulink and experimental results take from laboratory prototype to confirm the effectiveness of proposed structure and its control technique.
A General Model for the Design of Efficient Sign-Coding Tools for Wavelet-Based Encoders
Authors: López-Granado Otoniel Mario , Martínez-Rach Miguel Onofre , Martí-Campoy Antonio , Cruz-Chávez Marco Antonio , Malumbres Manuel Pérez
Published: November 2020

Traditionally, it has been assumed that the compression of the sign of wavelet coefficients is not worth the effort because they form a zero-mean process. However, several image encoders such as JPEG 2000 include sign-coding capabilities. In this paper, we analyze the convenience of including sign-coding techniques into wavelet-based image encoders and propose a methodology that allows the design of sign-prediction tools for whatever kind of wavelet-based encoder. The proposed methodology is based on the use of metaheuristic algorithms to find the best sign prediction with the most appropriate context distribution that maximizes the resulting sign-compression rate of a particular wavelet encoder. Following our proposal, we have designed and implemented a sign-coding module for the LTW wavelet encoder, to evaluate the benefits of the sign-coding tool provided by our proposed methodology. The experimental results show that sign compression can save up to 18.91% of bit-rate when enabling sign-coding capabilities. Also, we have observed two general behaviors when coding the sign of wavelet coefficients: (a) the best results are provided from moderate to high compression rates; and (b) the sign redundancy may be better exploited when working with high-textured images.
Genomic Selection for Forest Tree Improvement: Methods, Achievements and Perspectives
Authors: Lebedev Vadim G. , Lebedeva Tatyana N. , Chernodubov Aleksey I. , Shestibratov Konstantin A.
Published: November 2020

The breeding of forest trees is only a few decades old, and is a much more complicated, longer, and expensive endeavor than the breeding of agricultural crops. One breeding cycle for forest trees can take 20–30 years. Recent advances in genomics and molecular biology have revolutionized traditional plant breeding based on visual phenotype assessment: the development of different types of molecular markers has made genotype selection possible. Marker-assisted breeding can significantly accelerate the breeding process, but this method has not been shown to be effective for selection of complex traits on forest trees. This new method of genomic selection is based on the analysis of all effects of quantitative trait loci (QTLs) using a large number of molecular markers distributed throughout the genome, which makes it possible to assess the genomic estimated breeding value (GEBV) of an individual. This approach is expected to be much more efficient for forest tree improvement than traditional breeding. Here, we review the current state of the art in the application of genomic selection in forest tree breeding and discuss different methods of genotyping and phenotyping. We also compare the accuracies of genomic prediction models and highlight the importance of a prior cost-benefit analysis before implementing genomic selection. Perspectives for the further development of this approach in forest breeding are also discussed: expanding the range of species and the list of valuable traits, the application of high-throughput phenotyping methods, and the possibility of using epigenetic variance to improve of forest trees.
Population Genetic Diversity and Structure of Ancient Tree Populations of Cryptomeria japonica var. sinensis Based on RAD-seq Data
Authors: Cai Mengying , Wen Yafeng , Uchiyama Kentaro , Onuma Yunosuke , Tsumura Yoshihiko
Published: November 2020

Research highlights: Our study is the first to explore the genetic composition of ancient Cryptomeria trees across a distribution range in China. Background and objectives: Cryptomeria japonica var. sinensis is a native forest species of China; it is widely planted in the south of the country to create forests and for wood production. Unlike Cryptomeria in Japan, genetic Chinese Cryptomeria has seldom been studied, although there is ample evidence of its great ecological and economic value. Materials and methods: Because of overcutting, natural populations are rare in the wild. In this study, we investigated seven ancient tree populations to explore the genetic composition of Chinese Cryptomeria through ddRAD-seq technology. Results: The results reveal a lower genetic variation but higher genetic differentiation (Ho = 0.143, FST = 0.1204) than Japanese Cryptomeria (Ho = 0.245, FST = 0.0455). The 86% within-population variation is based on an analysis of molecular variance (AMOVA). Significant excess heterozygosity was detected in three populations and some outlier loci were found; these were considered to be the consequence of selection or chance. Structure analysis and dendrogram construction divided the seven ancient tree populations into four groups corresponding to the geographical provinces in which the populations are located, but there was no obvious correlation between genetic distance and geographic distance. A demographic history analysis conducted by a Stairway Plot showed that the effective population size of Chinese Cryptomeria had experienced a continuing decline from the mid-Pleistocene to the present. Our findings suggest that the strong genetic drift caused by climate fluctuation and intense anthropogenic disturbance together contributed to the current low diversity and structure. Considering the species’ unfavorable conservation status, strategies are urgently required to preserve the remaining genetic resources.
Modification of Fire Regimes Inferred from the Age Structure of Two Conifer Species in a Tropical Montane Forest, Mexico
Authors: Sáenz-Ceja Jesús Eduardo , Pérez-Salicrup Diego Rafel
Published: November 2020

Research Highlights: Age structure was used to infer fire regimes in the Monarch Butterfly Biosphere Reserve. Uneven-aged structures in stands dominated and co-dominated by pine and fir species, which are distributed according to an altitudinal gradient, indicated a regime of frequent, low-severity, and low-intensity fires. Background and Objectives: Age structure analyses have been used to infer natural and disrupted fire regimes when field-based descriptions of fires are scarce or unavailable. In montane conifer forests, fire regimes typically vary according to an altitudinal gradient, shaping contrasting tree establishment patterns. In the Monarch Butterfly Biosphere Reserve, Mexico, the altitudinal distribution and fire regimes of sacred fir forests (Abies religiosa), smooth-bark Mexican pine forests (Pinus pseudostrobus), and mixed-conifer forests are poorly documented. The objectives of this study were to determine the altitudinal ranges occupied by mono-dominant and co-dominant stands and to reconstruct tree establishment history to infer historical fire regimes. Materials and Methods: Six altitudinal transects were established along the reserve, each one at elevations from 2400 to 3300 m, with sampling sites at every 150 m of elevation. In each site, increment cores were collected from the base of 25 mature trees. A total of 800 increment cores were collected and cross-dated. Results: P. pseudostrobus is dominant in stands between 2400 and 2850 m, A. religiosa between 3150 and 3300 m, and both species co-dominate between 2850 and 3150 m. The establishment pattern for both species has been continuous, represented by uneven-aged structures, suggesting that tree establishment in smooth-bark Mexican pine forests, mixed-conifer forests, and sacred fir forests, is likely to be associated with frequent, low-severity, and low-intensity fires. Conclusions: These fire regimes suggest, by the one hand, the disruption of natural fire regimes by human activities, limiting the occurrence of high-severity fires; on the other hand, a distinctive feature of these tropical montane forests.
Large-Scale, Multidisciplinary Laboratory Teaching of Fluid Mechanics
Authors: Garrard Andrew , Bangert Krys , Beck Stephen
Published: November 2020

The nature of fluid mechanics makes experimentation an important part of a course taught on the subject. Presented here is the application of a novel, large-scale multidisciplinary model of practical education in a fluids engineering laboratory. The advantages of this approach include efficiencies through the economy of scale leading to better pedagogy for students. The scale justifies dedicated academic resources to focus on developing laboratory classes and giving specific attention to designing activities that meet learning outcomes. Four examples of applying this approach to fluid mechanics experiments are discussed, illustrating tactics that have been developed and honed through many repeated instances of delivery. “The measurement lab” uses a flow measurement context to teach identifying and managing general experimental uncertainty. In this lab, new students, unfamiliar with fluid mechanics, are guided through a process to gain understanding that can be applied to all future experimental activities. The “pressure loss in pipes” lab discusses the advantage of and process for sharing equipment and teaching resources between multiple cohorts. Here, the provision for students is adapted for context, such as the degree program or year of study. The “weirs big and small” lab provides a methodology for teaching the power of dimensional analysis to mechanical engineers using a field of fluid mechanics that is outside their usual theoretical studies. Finally, the “spillway design” lab discusses mechanisms for delivering independent, open-ended student experiments at scale, without excessive staff resource requirements.
Contribution of Foods and Poor Food-Handling Practices to the Burden of Foodborne Infectious Diseases in France
Authors: Augustin Jean-Christophe , Kooh Pauline , Bayeux Thomas , Guillier Laurent , Meyer Thierry , Jourdan-Da Silva Nathalie , Villena Isabelle , Sanaa Moez , Cerf Olivier ,   on Behalf of the Anses Working Group on Consumer Information on Foodborne Biological Risks
Published: November 2020

The foodborne disease burden (FBDB) related to 26 major biological hazards in France was attributed to foods and poor food-handling practices at the final food preparation step, in order to develop effective intervention strategies, especially food safety campaigns. Campylobacter spp. and non-typhoidal Salmonella accounted for more than 60% of the FBDB. Approximately 30% of the FBDB were attributed to 11 other hazards including bacteria, viruses and parasites. Meats were estimated as the main contributing food category causing (50–69%) (CI90) of the FBDB with (33–44%), (9–21%), (4–20%) (CI90) of the FBDB for poultry, pork and beef, respectively. Dairy products, eggs, raw produce and complex foods caused each approximately (5–20%) (CI90) of the FBDB. When foods are contaminated before the final preparation step, we estimated that inadequate cooking, cross-contamination and inadequate storage contribute for (19–49%), (7–34%) and (9–23%) (CI90) of the FBDB, respectively; (15–33%) (CI90) of the FBDB were attributed to the initial contamination of ready-to-eat foods—without any contribution from final food handlers. The thorough implementation of good hygienic practices (GHPs) at the final food preparation step could potentially reduce the FBDB by (67–85%) (CI90) (mainly with the prevention of cross-contamination and adequate cooking and storage).
Comparative Review of the Responses of Listeria monocytogenes and Escherichia coli to Low pH Stress
Authors: Arcari Talia , Feger Marie-Lucie , Guerreiro Duarte N. , Wu Jialun , O’Byrne Conor P.
Published: November 2020

Acidity is one of the principal physicochemical factors that influence the behavior of microorganisms in any environment, and their response to it often determines their ability to grow and survive. Preventing the growth and survival of pathogenic bacteria or, conversely, promoting the growth of bacteria that are useful (in biotechnology and food production, for example), might be improved considerably by a deeper understanding of the protective responses that these microorganisms deploy in the face of acid stress. In this review, we survey the molecular mechanisms used by two unrelated bacterial species in their response to low pH stress. We chose to focus on two well-studied bacteria, Escherichia coli (phylum Proteobacteria) and Listeria monocytogenes (phylum Firmicutes), that have both evolved to be able to survive in the mammalian gastrointestinal tract. We review the mechanisms that these species use to maintain a functional intracellular pH as well as the protective mechanisms that they deploy to prevent acid damage to macromolecules in the cells. We discuss the mechanisms used to sense acid in the environment and the regulatory processes that are activated when acid is encountered. We also highlight the specific challenges presented by organic acids. Common themes emerge from this comparison as well as unique strategies that each species uses to cope with acid stress. We highlight some of the important research questions that still need to be addressed in this fascinating field.
Molecular Mechanisms and Biological Functions of Autophagy for Genetics of Hearing Impairment
Authors: Hayashi Ken , Suzuki Yuna , Fujimoto Chisato , Kanzaki Sho
Published: November 2020

The etiology of hearing impairment following cochlear damage can be caused by many factors, including congenital or acquired onset, ototoxic drugs, noise exposure, and aging. Regardless of the many different etiologies, a common pathologic change is auditory cell death. It may be difficult to explain hearing impairment only from the aspect of cell death including apoptosis, necrosis, or necroptosis because the level of hearing loss varies widely. Therefore, we focused on autophagy as an intracellular phenomenon functionally competing with cell death. Autophagy is a dynamic lysosomal degradation and recycling system in the eukaryotic cell, mandatory for controlling the balance between cell survival and cell death induced by cellular stress, and maintaining homeostasis of postmitotic cells, including hair cells (HCs) and spiral ganglion neurons (SGNs) in the inner ear. Autophagy is considered a candidate for the auditory cell fate decision factor, whereas autophagy deficiency could be one of major causes of hearing impairment. In this paper, we review the molecular mechanisms and biologic functions of autophagy in the auditory system and discuss the latest research concerning autophagy-related genes and sensorineural hearing loss to gain insight into the role of autophagic mechanisms in inner-ear disorders.
Numerical Modelling to Evaluate Sedimentation Effects on Heat Flow and Subsidence during Continental Rifting
Authors: Kim Yeseul , Huh Min , Lee Eun Young
Published: November 2020

Sedimentation impacts thermal and subsidence evolution in continental rifting. Estimating the blanketing effect of sediments is crucial to reconstructing the heat flow during rifting. The sedimentary load affects the basin subsidence rate. Numerical investigation of these effects requires active and complex simulations of the thermal structure, lithospheric stretching, and sedimentation. In this paper, we introduce a numerical model to quantify these effects, which was developed using the COMSOL Multiphysics® simulation software. Our numerical setting for the analytical and numerical solutions of thermal structure and subsidence is based on previous continental rifting studies. In our model, we accumulate a column of 5 m thick sediment layers with varied stretching factors and sedimentation rates, spanning the syn-rift to early post-rift phases over a period of 12 myr. Our results provide intuitive models to understand these sedimentation effects. The models show that an increase in sedimentation thickness significantly decreases surface heat flow, leading to lower geothermal temperature, and amplifies the subsidence magnitude. The findings also demonstrate that increases in the stretching factor and sedimentation rate enhance the blanketing effect and subsidence rate. Based on these results, we discuss key outcomes for geological applications and the possible limitations of our approach.
Constraints on Martian Chronology from Meteorites
Authors: Váci Zoltán , Agee Carl
Published: November 2020

Martian meteorites provide the only direct constraints on the timing of Martian accretion, core formation, magmatic differentiation, and ongoing volcanism. While many radiogenic isotope chronometers have been applied to a wide variety of Martian samples, few, if any, techniques are immune to secondary effects from alteration and terrestrial weathering. This short review focuses on the most robust geochronometers that have been used to date Martian meteorites and geochemically model the differentiation of the planet, including 147Sm/143Nd, 146Sm/142Nd, 176Lu/176Hf, 182Hf/182W, and U-Th-Pb systematics.
Correction of Myopic Astigmatism with Topography-Guided Laser In Situ Keratomileusis (TOPOLINK)
Authors: Wu Pei-Lun , Lee Chia-Yi , Cheng Han-Chih , Lin Hung-Yu , Lai Li-Ju , Wu Wei-Chi , Chen Hung-Chi
Published: November 2020

We aim to assess the feasibility of topography-guided laser in situ keratomileusis (TOPOLINK) for correcting pre-existing and surgical-induced astigmatism. A retrospective, single center cohort study was conducted. Patients with pre-existing irregular myopic astigmatism were recruited into the primary group and those with irregular myopic astigmatism following laser in situ keratomileusis (LASIK) were recruited into the enhancement group. The changes in uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), maximum astigmatism, spherical equivalent (SE) and patient satisfaction were recorded. The Chi-square test, Mann–Whitney U test and Generalized Linear Mixed Model were utilized for the analysis in the current study. A total of 18 eyes were studied in the primary group and 14 eyes were examined in the enhancement group. One year postoperatively, the UCVA, BCVA, maximum astigmatism and SE improved significantly in both the primary and the enhancement groups (all p < 0.05). The UCVA (p = 0.046) and SE (p = 0.003) were worse in the primary group preoperatively but became similar in both groups postoperatively, while the BCVA and maximum astigmatism remained identical between groups throughout the study period (all p < 0.05). In addition, the rate of high and moderate satisfaction reached 90.0% in the primary and the enhancement groups, without significant differences (p = 0.871). In conclusion, the TOPOLINK showed high predictability and will contribute to similar outcomes between primary and postoperative irregular myopic astigmatism concerning visual acuity, refractive status and subject satisfaction.
The Mediating Role of Goal Orientation (Task) in the Relationship between Engagement and Academic Self-Concept in Students
Authors: Usán Supervía Pablo , Salavera Bordás Carlos , Lorente Víctor Murillo
Published: November 2020

Some students many not possess the necessary strategies and skills to meet the demands of academic life and develop negative attitudes, physical and mental exhaustion, and other attitudes that will undermine their personal and academic development. This study analyses the relationship and possible role of goal orientation as a mediator between engagement and academic self-concept. Methods: The study concerned a population of 1756 subjects from 12 secondary schools (ESO). The instruments used included the Utrecht Work Engagement Scale—Student (UWES-S), the Perception of Success Questionnaire (POSQ), and the Academic Self-Concept Scale (ASCS). Results: The results revealed significant correlations between academic engagement, task-oriented goal orientation, and academic self-concept. In addition, task orientation was found to play a positive mediating role between academic engagement and academic self-concept, leading to adaptive models in secondary school students. Conclusion: These results highlight the need to promote goal orientation in order to stimulate self-determined behaviours in the school environment and improved levels of academic self-concept, which in turn will facilitate the psychological and personal development of the student and increase the chances of academic success.
Impact of Time to Initiation of Treatment on the Quality of Life of Women with Breast Cancer
Authors: Konieczny Magdalena , Cipora Elżbieta , Roczniak Wojciech , Babuśka-Roczniak Magdalena , Wojtaszek Marek
Published: November 2020

Introduction: Breast cancer is the most common malignancy in women. Due to the large number of women living with breast cancer and the increasing incidence of this cancer, it is very important to understand the factors determining the quality of life (QOL) of patients. The aim of the study. The aim of the study was to determine the impact of time to initiation of treatment on the quality of life of women with breast cancer. Materials and methods. The study involved 324 women with breast cancer, treated at the Podkarpackie Oncology Centre in Brzozów, Poland. The study was conducted using a diagnostic survey, using a standardised questionnaire to measure the quality of life of women treated for breast cancer, i.e., the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC) QLQ-C30 and the QLQ-BR23 module, as well as a proprietary survey questionnaire. Statistical analysis was performed using the Statistica 10.0 software (StatSoft Inc., 2011). A p value of <0.05 was considered statistically significant. Results: The examined women had a reduced overall quality of life and health (M = 53.88). The quality of life was higher in women who consulted a doctor the earliest after noticing initial symptoms of the disease, i.e., up to one week (M = 57.58), compared to patients who delayed the decision (over four weeks; M = 47.8) (p = 0.002). The quality of life was also considered higher by women who received treatment within two weeks of diagnosis (M = 56.79) and was lower for patients who waited for treatment for more than two months (M = 43.68). Statistically significant relationships were demonstrated for functional scales and disease intensity. Conclusions: Women diagnosed with breast cancer had a considerably lower overall quality of life. A relatively higher quality of life was experienced by patients who consulted a doctor the earliest after discovering symptoms of the disease and those whose waiting time for treatment was shorter. In a systematic manner, the individual stages of diagnosis should be maximally reduced and breast cancer treatment initiated without delay.
Disposable and Low-Cost Colorimetric Sensors for Environmental Analysis
Authors: Alberti Giancarla , Zanoni Camilla , Magnaghi Lisa Rita , Biesuz Raffaela
Published: November 2020

Environmental contamination affects human health and reduces the quality of life. Therefore, the monitoring of water and air quality is important, ensuring that all areas are acquiescent with the current legislation. Colorimetric sensors deliver quick, naked-eye detection, low-cost, and adequate determination of environmental analytes. In particular, disposable sensors are cheap and easy-to-use devices for single-shot measurements. Due to increasing requests for in situ analysis or resource-limited zones, disposable sensors’ development has increased. This review provides a brief insight into low-cost and disposable colorimetric sensors currently used for environmental analysis. The advantages and disadvantages of different colorimetric devices for environmental analysis are discussed.
Effects of Incubation of Human Brain Microvascular Endothelial Cells and Astrocytes with Pyridostigmine Bromide, DEET, or Permethrin in the Absence or Presence of Metal Salts
Authors: Hoffman Jessica F. , Kalinich John F.
Published: November 2020

Gulf War Illness (GWI) is a chronic, multi-symptom illness suffered by over one-third of American military veterans who served in the Persian Gulf War between 1990 and 1991. No current single-exposure scenario accounts for all the symptoms observed in GWI, and instead may be due to a multi-exposure scenario. As a larger effort to understand how one category of multi-exposure scenarios of organic compounds such as nerve gas prophylactic pyridostigmine bromide, or insecticides/pesticides such as N,N-diethyl-m-toluamide (DEET) and permethrin, plus heavy metals found in inhaled dust particles (Al, Fe, Ni, Sr, DU, Co, Cu, Mn, and Zn) might play a role in neural aspects of GWI, we begin this initial study to examine the toxicity and oxidative damage markers of human brain endothelial cell and human astrocyte cell cultures in response to these compounds. A battery of cytotoxicity assessments, including the MTT assay, Neutral Red uptake, and direct microscopic observation, was used to determine a non-toxic dose of the test compounds. After testing a wide range of doses of each compound, we chose a sub-toxic dose of 10 µM for the three organic compounds and 1 µM for the nine metals of interest for co-exposure experiments on cell cultures and examined an array of oxidative stress-response markers including nitric oxide production, formation of protein carbonyls, production of thiobarbituric acid-reactive substances, and expression of proteins involved in oxidative stress and cell damage. Many markers were not significantly altered, but we report a significant increase in nitric oxide after exposure to any of the three compounds in conjunction with depleted uranium.
A Basic Study on the Performance Evaluation of a Movable Light Shelf with a Rolling Reflector That Can Change Reflectivity to Improve the Visual Environment
Authors: Lee Heangwoo
Published: November 2020

In recent years, the need for comfortable visual environments in indoor spaces has increased energy use in buildings. There have been diverse studies on using a light shelf to solve this problem. It is an effective system that allows external natural light deep into indoor spaces through reflection. However, prior studies have used light shelves with a fixed reflectivity, and there are few studies on improving the visual environment through light shelf control. Therefore, this study proposes a movable light shelf with a rolling reflector that can change the reflectivity. To achieve these objectives, we conducted a performance evaluation of the system’s ability to save energy and improve the visual environment. This study built a real scale testbed and conducted a performance evaluation by deriving values for lighting energy consumption, uniformity, and luminance contrast depending on the light shelf variables. We conclude that (1) the light shelf system achieved an energy savings of 13.6% and 5.7%, respectively, compared to a fixed type light shelf, whose reflectivity cannot be changed, and a traditional movable light shelf; (2) in terms of improving the visual environment, results suggest that the visual environment could be improved using a light shelf by deriving light shelf variables that disturb indoor uniformity; and (3) the results verified glare generation conditions by deriving luminance contrast caused by the variables of light shelf angle and its reflectivity.
Iodine Status of Women and Infants in Russia: A Systematic Review
Authors: Korobitsyna Rimma , Aksenov Andrey , Sorokina Tatiana , Trofimova Anna , Sobolev Nikita , Grjibovski Andrej M , Chashchin Valery , Thomassen Yngvar
Published: November 2020

This systematic review presents a critical synthesis of the available information on the iodine status among women and infants in Russia. Literature search was performed in accordance with PRISMA guidelines using PubMed, Scopus Web of Science databases as well as eLIBRARY—the Russian national source. Altogether, 277 papers were identified and 19 of them were eligible for the review. The data on median urinary iodine concentration (UIC) in women and infants from 25 Russian regions were presented. A substantial variability in UIC across the country with no clear geographical pattern was observed. Despite substantial heterogeneity in research methodology and data presentation the results suggest that the iodine status among pregnant women and infants in Russia is below the recommended levels. Our findings demonstrate that iodine deficiency is a re-emerging public health problem in Russia. Urgent public health measures on national, regional and individual levels are warranted.
Patients with Kawasaki Disease Have Significantly Low Aerobic Metabolism Capacity and Peak Exercise Load Capacity during Adolescence
Authors: Yang Tsung-Hsun , Lee Yan-Yuh , Wang Lin-Yi , Chang Ta-Chih , Chang Ling-Sai , Kuo Ho-Chang
Published: November 2020

Introduction: Kawasaki disease (KD) is a childhood illness causing blood vessel inflammation. Children with KD have similar cardiopulmonary function to healthy children, but lower moderate-to-vigorous activity and exercise self-efficacy—possibly harming their cardiopulmonary function in adolescence. The purpose of this study is to investigate the cardiopulmonary function, exercise behaviors, exercise motivations, and self-efficacy of adolescents who once had KD. Methods: adolescents who once had KD and adolescents matched to the KD group in age and sex were enrolled. The cardiopulmonary exercise test was used to assess cardiopulmonary function. Weekly exercise behavior, exercise motivation, and self-efficacy were assessed with questionnaires. Results: this study recruited 50 and 30 participants, respectively, to the KD and control groups. The KD group had a lower ratio of VO2/kg at the anaerobic threshold and peak to the predicted VO2/kg at the peak (p = 0.021 and 0.043, respectively). No significant differences were found in questionnaire scores. The correlations of weekly exercise behavior scores with exercise motivation and self-efficacy scores were stronger in the KD group. Conclusions: adolescents with KD history had significantly lower aerobic metabolism capacity and peak exercise load capacity than controls. The correlations of amount of weekly exercise with exercise motivation and self-efficacy were stronger in the KD group.
Psychological Adjustment of Healthcare Workers in Italy during the COVID-19 Pandemic: Differences in Stress, Anxiety, Depression, Burnout, Secondary Trauma, and Compassion Satisfaction between Frontline and Non-Frontline Professionals
Authors: Trumello Carmen , Bramanti Sonia Monique , Ballarotto Giulia , Candelori Carla , Cerniglia Luca , Cimino Silvia , Crudele Monia , Lombardi Lucia , Pignataro Silvia , Viceconti Maria Luisa , Babore Alessandra
Published: November 2020

Emergency situations have been associated with negative psychological adjustment outcomes in healthcare professionals, although studies on the impact of the Coronavirus Disease 2019 (COVID-19) pandemic amongst Italian health workers are limited. The main aim of this study was to investigate the psychological adjustment of healthcare professionals during the peak of the COVID-19 pandemic, evaluating differences according to working or not with patients affected by COVID-19 and in areas with a more severe spread of this pandemic. Healthcare professionals’ attitudes toward psychological support were analyzed. The levels of anxiety, depression, psychological stress, and professional quality of life (compassion satisfaction, burnout, and compassion fatigue) and attitudes toward psychological support were measured among 627 Italian healthcare workers (mean age = 40.55 years; SD = 11.49; range: 27–72). Significantly higher levels of stress, burnout, secondary trauma, anxiety, and depression were observed among professionals working with COVID-19 patients. Higher levels of stress and burnout and lower levels of compassion satisfaction were detected in professionals working in areas with higher rates of contagion. No interaction effects were found between working (or not) with patients affected by COVID-19 and working (or not) in areas with a more severe diffusion of this pandemic. Finally, in the group of professionals who worked with COVID-19 patients, the percentage of professionals who thought to ask for psychological support was twice that of the group that did not work with COVID-19 patients. The overall findings indicate that the mental health of frontline healthcare workers requires further consideration and that targeted prevention and intervention programs are necessary.
Look Alike, Sound Alike: Phenocopies in Steroid-Resistant Nephrotic Syndrome
Authors: Becherucci Francesca , Landini Samuela , Cirillo Luigi , Mazzinghi Benedetta , Romagnani Paola
Published: November 2020

Steroid-resistant nephrotic syndrome (SRNS) is a clinical picture defined by the lack of response to standard steroid treatment, frequently progressing toward end-stage kidney disease. The genetic basis of SRNS has been thoroughly explored since the end of the 1990s and especially with the advent of next-generation sequencing. Genetic forms represent about 30% of cases of SRNS. However, recent evidence supports the hypothesis that “phenocopies” could account for a non-negligible fraction of SRNS patients who are currently classified as non-genetic, paving the way for a more comprehensive understanding of the genetic background of the disease. The identification of phenocopies is mandatory in order to provide patients with appropriate clinical management and to inform therapy. Extended genetic testing including phenocopy genes, coupled with reverse phenotyping, is recommended for all young patients with SRNS to avoid unnecessary and potentially harmful diagnostic procedures and treatment, and for the reclassification of the disease. The aim of this work is to review the main steps of the evolution of genetic testing in SRNS, demonstrating how a paradigm shifting from “forward” to “reverse” genetics could significantly improve the identification of the molecular mechanisms of the disease, as well as the overall clinical management of affected patients.
A Three-Dimensional Visualization Framework for Underground Geohazard Recognition on Urban Road-Facing GPR Data
Authors: Wang Zhenwu , Wan Benting , Han Mengjie
Published: November 2020

The identification of underground geohazards is always a difficult issue in the field of underground public safety. This study proposes an interactive visualization framework for underground geohazard recognition on urban roads, which constructs a whole recognition workflow by incorporating data collection, preprocessing, modeling, rendering and analyzing. In this framework, two proposed sampling point selection methods have been adopted to enhance the interpolated accuracy for the Kriging algorithm based on ground penetrating radar (GPR) technology. An improved Kriging algorithm was put forward, which applies a particle swarm optimization (PSO) algorithm to optimize the Kriging parameters and adopts in parallel the Compute Unified Device Architecture (CUDA) to run the PSO algorithm on the GPU side in order to raise the interpolated efficiency. Furthermore, a layer-constrained triangulated irregular network algorithm was proposed to construct the 3D geohazard bodies and the space geometry method was used to compute their volume information. The study also presents an implementation system to demonstrate the application of the framework and its related algorithms. This system makes a significant contribution to the demonstration and understanding of underground geohazard recognition in a three-dimensional environment.