bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifikasi dan Analisis Efektivitas Penanganan Blackspot di Jalan Perkotaan (Studi Kasus: Kota Depok)
Authors: Adhikaratma Hizkia , . Karina , Kinansyahputra Muhammad Rifqi , Septiawan Ahmad , Siregar Martha Leni
Published: February 2023

This research was conducted to identify blackspots, determine the diagnosis and causes of accidents at the blackspot in Depok City, and develop a program for handling them. The method to identify the blackspot is the network screening method with the simple ranking method, ACF, and EPDO. In this study, a blackspot was found on Jalan Raya Bogor (in front of Pertamina gas stations), Sukamaju, Kec. Cilodong, Depok City. Traffic accidents that occur tend to be front-back and front-front collisions involving pedestrians and often occur at night with dim lighting conditions. There are several ways to handle blackspots or mitigating accidents, such as the installation of rumble strips, zebra cross, street lighting, signs, and tree logging. After handling the blackspot, the number of accidents is predicted to decrease from 7 to 3 accidents. The BCR value is 93,663 > 1, so that the treatment program is feasible to be implemented.

ABSTRAK

Penelitian ini dilakukan untuk mengidentifikasi blackspot, mengetahui diagnosis dan penyebab kecelakaan pada titik blackspot Kota Depok, serta menyusun program penanganan dan perbaikannya. Metode untuk menentukan titik-titik blackspot adalah network screening method dengan metode simple ranking, ACF, dan EPDO. Pada penelitian ini didapatkan titik blackspot di Jalan Raya Bogor Km. 37 (depan SPBU Pertamina 34.164.05), Sukamaju, Kec. Cilodong, Kota Depok. Kecelakaan lalu lintas yang terjadi cenderung bertipe tabrakan depan-belakang dan depan-depan yang melibatkan pejalan kaki dan dominan terjadi pada malam hari dengan kondisi pencahayaan redup. Penanganan yang dilakukan pada blackspot yaitu pemasangan pita penggaduh, zebra cross, lampu penerangan jalan, rambu-rambu, dan penebangan pohon. Setelah adanya penanganan blackspot, angka kecelakaan diprediksi berkurang dari 7 menjadi 3 kecelakaan. Didapatkan nilai BCR sebesar 93,663 > 1 sehingga program penanganan layak untuk dilaksanakan.
Editorial: Effects of aging on locomotor patterns
Authors: Santos Paulo C. R. , Orcioli-Silva Diego
Published: February 2023

Aging and age-associated neurological diseases, such as Alzheimer's disease and Parkinson's disease, may impair walking performance. Changes in walking performance are related to an increase in fall risk, institutionalization, hospitalization, survival rate, and mortality. Due to the increase in the older population, especially age-related diseases, the number of research aiming at understanding the mechanisms behind such changes and tools (interventions) to improve walking performance has increased substantially. In this special issue, we target to compile information and strengthen the discussion about whether and how aging and AD, and PD affect walking (the most common way of human locomotion), and potential interventions to improve walking in these populations. A total of 5 studies composed this special issue, including 4 original papers and 1 review
Reflection of Light as a Mechanical Phenomenon Applied to the Michelson Interferometer with Light from the Sun
Authors: Dambi  Filipescu Filip
Published: February 2023

The Sun is a frame at relative rest in which sunlight travels at the emitted speed c. Earth travels at the revolving speed v in this frame. The reflection of light as a mechanical phenomenon applies to the modified Michelson interferometer employed by Miller in his experiments with light from the Sun. Unlike the Tomaschek experiments, which use light from stars that may travel in the Universe at velocities different from that of the Sun, the fringe shifts in the Miller experiments are predictable. Based on Michelson's derivation, Miller expected in his experiments at Mount Wilson a 1.12 fringe shift and observed a fringe shift of 0.08 in 1921 and 0.088 in 1925. The reflection of light as a mechanical phenomenon predicts zero fringe shift for Miller's experiment agreeing only with his observations at the Cleveland laboratory in 1924.
Application of Human Stem Cells to Model Genetic Sensorineural Hearing Loss and Meniere Disease
Authors: Lamolda Mar , Frejo Lidia , Gallego-Martinez Alvaro , Lopez-Escamez Jose Antonio
Published: February 2023

Genetic sensorineural hearing loss and Meniere disease have been associated with rare variations in the coding and non-coding region of the human genome. Most of these variants are classified as likely pathogenic or variants of unknown significance and require functional validation in cellular or animal models. Given the difficulties to obtain human samples and the raising concerns about animal experimentation, human induced pluripotent stem cells emerge as cellular models to investigate the interaction of genetic and environmental factors in the pathogenesis of inner ear disorders. The generation of human sensory epithelia and neuron-like cells carrying the variants of interest may facilitate a better understanding of their role during differentiation. These cellular models will allow us to explore new strategies for restoring hearing and vestibular sensory epithelia as well as neurons. This review summarizes the use of human induced pluripotent stem cells in sensorineural hearing loss and Meniere disease and proposes some strategies for its application in clinical practice.
Antioxidant and Potential Non-antioxidant Roles of Vitamin E in Reproduction of Male Domestic Animals
Authors: Gao Yuefeng , Qin Dongmei , Shen Yangyang , Jian Luyang , Gu Peilun
Published: February 2023

Vitamin E facilitates testicular development and semen quality in farm animal. And most research tends to investigate antioxidant roles of Vitamin E in reproductive health; some research also find potential non-antioxidant roles of Vitamin E. To further uncover the mechanism by which Vitamin E modulates reproductive health, the paper reviews specific function of Vitamin E and candidate genes involved in male reproductive performance promoted by Vitamin E. The review found that cell proliferation (PDPN, BMP, Myc, AMPKa, GSK3β, PPARγ, CDK4, CDK6, Ki67, PCNA, Cyclin A2, Cyclin B1, Cyclin B3, BLM, REL, KLHL25)-, cell apoptosis (BCL-2, Caspase 9, Bax)-, spermatogenesis (CatSper1, CatSper2, NDRG1, CYP26B1, FSCN3, FLNA, SPCS3, YBX3, RARS)-, hormone receptor (PGR, FSHR, AR)-related genes are the underlying key points. And two miRNAs, miR-107 and miR-493-3p, which mediate cell cycle process, are also identified in response to Vitamin E treatment. The paper paves the way for a comprehensive understanding about effect of Vitamin E on testis development and semen quality in domestic animals.
Dual Extended State Observer Based Feedback Linearizing Control for Magnetic Levitation System with Mismatched Disturbances and Uncertainties
Authors: Gandhi Ravi V. , Adhyaru Dipak M. , Sharma Gulshan , Bokoro Pitshou
Published: February 2023

This research work presents the nonlinear control framework to estimate and reject the mismatched lumped disturbances acting on the nonlinear uncertain system. It is an unfortunate fact that the conventional Extended State Observer (ESO) is not capable to estimate the mismatched lumped disturbance and its derivative simultaneously for the systems. Also, the basic ESO is only suitable for systems with Integral Chain Form (ICF) structure. Similarly, the conventional Feedback Linearizing Control (FLC) approach is not robust for stabilizing the systems in the presence of disturbances and uncertainties. Hence, the nonlinear control framework is proposed to overcome the above issues which are composed of, (a) Dual Extended State Observer (DESO), and (b) DESO based FLC. The DESO provides information on the unmeasured state, mismatched disturbance, and its derivative. While the DESO-FLC utilizes the information from DESO to counter the effect of such disturbances and to stabilize the nonlinear systems around the reference point. The detailed closed-loop analysis is presented for the proposed control framework in the presence of lumped disturbances. The performance robustness of the presented design has been validated for the third order, nonlinear, unstable, and disturbed Magnetic Levitation System (MLS). The results of the DESO-FLC approach are compared with the most popular Linear Quadratic Regulator (LQR) and nonlinear FLC approaches based on the integral error criterion and the average electrical energy consumption.
First Clinical Comparison of STANDARD F TB-Feron FIA and the QIAreachTM QuantiFERON-TB for Tuberculosis Infection in Tertiary Public Hospital in South America
Authors: Saint-Pierre Gustavo , Conei Daniel , Cantillana Patricia , Raijmakers Mariella , Vera Andrea , Gutierrez Daniela , Kennedy Cristopher , Peralta Paulina , Ramonda Paulina
Published: February 2023

Introduction: Tuberculosis (TB) is one of the most prevalent respiratory diseases in the world. In 2020 there were at least 9.9 million new infections, with 1.5 million deaths. Approximately 10% of people infected with Mycobacterium tuberculosis (LTBI) develop the disease during the first 2 to 5 years after infection. Currently in South America, the diagnosis of LTBI continues to be per-formed through the Mantoux tuberculin skin test (TST). Objective: The objective of our study was to compare the sensitivity of a new immunofluorescence IGRA test against a widely available IGRA kit on the market. Material and method: Close contact to infectious patients with TB, or HIV patients or immunocompromised for another cause were recruited. Two interferon gamma release assay (IGRA) diagnostic kits were used and compared with TST. Results: 76 patients were recruited. 93.42% were Chilean nationality, 98.68% of the patients did not have immunosuppres-sion. The sensitivity of the new technique was 88.89% and specificity 92.50% in the study popula-tion compared to the IGRA previously used. In the subgroup older than 36 years, the sensitivity was 95.65% and the specificity 89.47%. Conclusion: IGRA techniques are a new resource in clini-cal laboratories to be able to make an accurate diagnosis in LTBI in the region of the Americas. In our population, the greatest benefit of this new IGRA would be observed in people over 36 years of age, where the sensitivity of the technique was like that of the currently available test.
High Accuracy Detection Technique for Information Data Under the Influence of Multiple Factors based on Fractional Partial Differential Equations
Authors: Zuo Yanhong , Cheng Hua
Published: February 2023

In engineering practice, various types of information data are affected by many factors during the collection process. For example, information data measurement errors are caused by equipment performance and the working environment. During the transmission of detection information, the signal distortion caused by energy loss and signal interference causes unpredictable detection errors in the collected information data. Through the study of fractional calculus theory, it was found that it is suitable for studying nonlinear, non-causal, and non-stationary signals, and has the dual functions of improving detection information and enhancing signal strength. Therefore, under the influence of many factors, we applied the fractional difference algorithm to the field of information data processing. Multi-sensor detection data fusion algorithm based on the fractional partial differential equation was adopted to establish its online detection data. A multi-sensor detection data fusion algorithm based on a fractional partial differential equation is established, which effectively fuses the information data detection errors caused by various influencing factors and greatly improves the detection accuracy of information data. The effectiveness of this method is proved through its application in an experiment.
Multilayer and Multilevel Cosmological Models Based on So-Lutions of the Extended Einstein Field Equations
Authors: Batanov-Gaukhman Mikhail
Published: February 2023

This article proposes the multilayer and multilevel cosmological model, on average, balanced with respect to the Einsteinian vacuum. This hierarchical model is based on 10 possible Kottler solutions of the extended Einstein's field equations. The extension of the Einstein field equations is associated with the addition of an infinite number of lambdaj-terms to these equations with the condition that the series (i.e., the total sum) of these terms converges to zero. A simplified ten-layer and ten-level case is considered, in which ten spherical formations are sequentially nested into each other like "nesting dolls", while the radii of these spherical formations correspond to the characteristic sizes of a discrete sequence of observed spherical objects: metagalaxy core, galactic cores, stellar (planet) core, biological cells and nuclei of atoms and elementary particles, etc. As an example, from the general ten-level (hierarchical) solution of extended Einstein's field equations, two antipodal spherical formations with a core radius commensurate with the classical electron radius are singled out. Therefore, the metric-dynamic models of these formations obtained in this way are called «electron» and «positron». The article is aimed at the development of differential geometry and the program for the complete geometrization of physics by Clifford-Einstein-Wheeler.
Network Modelling of Murine Lymphatic System
Authors: Grebennikov Dmitry , Savinkov Rostislav , Zelenova Ekaterina , Lobov Gennady , Bocharov Gennady
Published: February 2023

Animal models of diseases in particular, the mice, are considered to be the cornerstone for translational research in immunology. The aim of the present study is to model the geometry and analyze the network structure of murine lymphatic system (LS). The algorithm for building the graph model of the LS makes use of anatomical data. To identify the edge directions of the graph model, a mass balance approach to lymph dynamics based on Hagen-Poiseuille equation is applied. It is the first study in which a geometric model of the murine LS has been developed and characterized in terms of its structural organization and the lymph transfer function. Our study meets the demand for quantitative mechanistic approaches in the growing field of immunoengineering to utilize or exploit the lymphatic system for immunotherapy.
The Impact of Transjugular Intrahepatic Portosystemic Shunt on Nutrition in Liver Cirrhosis Patients: A Systematic Review
Authors: Gazda Jakub , Di Cola Simone , Lapenna Lucia , Khan Saniya , Merli Manuela
Published: February 2023

Background and Aims: Liver cirrhosis leads to clinically significant portal hypertension. Transjugular intrahepatic portosystemic shunt (TIPS) has been shown to effectively reduce the degree of portal hypertension and treat its complications. However, poor nutritional status has been shown to be associated with hepatic encephalopathy, acute on chronic liver failure, and mortality following TIPS placement. The purpose of this systematic review is to create another perspective and evaluate the effect of TIPS placement on the nutritional status of patients with liver cirrhosis. Methods: A comprehensive search of four major electronic databases was conducted to identify studies that assessed the nutritional status of cirrhotic patients before and after TIPS placement. The risk of bias was evaluated using ROBINS-I guidelines. Results: Fifteen studies were analyzed in this review. The results indicate that among the 11 studies that evaluated changes in ascites-free weight and body mass index or body cell mass, 10 reported an improvement in one or more measures. Furthermore, all 7 studies that evaluated changes in muscle mass demonstrated an increase in muscle mass. Among the 4 studies that evaluated subcutaneous fat tissue, 3 showed a significant expansion, while 2 out of 3 studies evaluating visceral fat tissue reported a significant reduction. Conclusion: The results of this systematic review suggest that TIPS placement is associated with improvement in the nutritional status of cirrhotic patients, indicated by an increase in ascites-free weight, body mass index, and muscle mass. Additionally, TIPS placement leads to a shift in the distribution of fat mass, with a preference for subcutaneous over visceral adipose tissue. Notably, sarcopenic patients seem to benefit the most from TIPS placement in terms of the nutritional status.
Post or Perish? Social Media Strategies for Disseminating Orthopedic Research
Authors: Buettmann Evan , Chlebek Carolyn , Lockard Carly , Clayton Sade , Lewis Karl , Collins Kelsey
Published: February 2023

The purpose of this paper is to highlight the main themes and insights from the Journal of Orthopedic Research (JOR)/JOR Spine Workshop during the Orthopedic Research Society 2022 Annual Meeting in Tampa Bay, Florida. This workshop, organized by JOR Editor-in-Chief Dr. Linda Sandell, focused on communication strategies (particularly using social media) to broadcast published work in orthopedic research. In this manuscript, we summarize data that support the beneficial impacts of amplifying scholarly works on social media and outline a linearized workflow for constructing a Twitter posts, which can be generalized to other social media platforms, to share academic research. Finally, we identify resources to alleviate barriers to social media use and help promote professionalism and success online in the orthopedic research community. As early career scientists in orthopedics, we see immense value in using social media, particularly Twitter, to communicate our research findings and build our scholarly networks. We hope this information will be persuasive to those in the orthopedic field and be broadly applicable to others in related scientific fields who wish to disseminate findings and engage a public audience on social media. For the orthopedic research society and journal of orthopedic research, social media can assist in accomplishing our mission of creating a world without musculoskeletal limitations via the timely dissemination of orthopedic research findings and news.
Truth as Consistent Assertion
Authors: Rozycki Adam
Published: February 2023

This paper presents four key results. Firstly, it distinguishes between partial and consistent assertion of a sentence, and introduces the concept of an equivocal sentence, which is both partially asserted and partially denied. Secondly, it proposes a novel definition of truth, stating that a true sentence is one that is consistently asserted. This definition is immune from the Liar paradox, does not restrict classical logic, and can be applied to declarative sentences in the language used by any particular person. Thirdly, the paper introduces an epistemic model of language, known as assertional language, which is used to formalize the definition of truth. Finally, it provides an argument for the falsity of so-called Liar sentences. The paper also discusses Tarski's solution to the Liar paradox and argues for the abandonment of the Tarski Scheme: 'p' is true if and only if p, in the context of everyday language. The proposed definition of truth can be viewed as a formal account of the correspondence theory. The epistemic model is a powerful concept on its own that allows for combining different languages in a meaningful way. This model is uniquely capable of reflecting on epistemic inconsistencies, such as logical paradoxes, in a consistent manner.
Structure-Function of the Human WAC Protein in GABAergic Neurons: Towards an Understanding of Autosomal Dominant DeSanto-Shinawi Syndrome
Authors: Rudolph Hannah C , Stafford April M , Hwang Hye-Eun , Kim Cheol-Hee , Prokop Jeremy W , Vogt Daniel
Published: February 2023

Dysfunction of the WW domain-containing adaptor with coiled-coil, WAC, gene underlies a rare autosomal dominant disorder, DeSanto-Shinawi syndrome (DESSH). DESSH is associated with facial dysmorphia, hypotonia, and cognitive alterations, including attention deficit hyperactivity disorder and autism. How the WAC protein localizes and functions in neural cells is critical to understanding its role during development. To understand the genotype-phenotype role of WAC, we developed a knowledgebase of WAC expression, evolution, human genomics, and structural/motif analysis combined with human protein domain deletions to assess how conserved domains guide cellular distribution. Then assessed in a cell type implicated in DESSH, cortical GABAergic neurons. WAC contains conserved charged amino acids, phosphorylation signals, and enriched nuclear motifs, suggesting a role in cellular signaling and gene transcription. Human DESSH variants are found within these regions. We also discovered and tested a nuclear localaization domain that impacts the cellular distribution of the protein. These data provide new insights into the potential roles of this critical developmental gene, establishing a platform to assess further translational studies, including the screening of missense genetic variants in WAC. Moreover, these studies are essential for understanding the role of human WAC variants in more diverse neurological phenotypes, including autism spectrum disorder.
Research Leadership in Africa: Perspectives from the Social Sciences, Humanities, and Arts
Authors: Ogega Obed , Majani Mary , Hendricks Cheryl , Adegun Olumuyiwa , Mbatudde Maria , Muyanja Charles , Atekyereza Peter , Hugue Ngandeu N. , Gyasi Razak M.
Published: February 2023

Global and human development and freedoms increasingly thrive on robust and policy-oriented research and related activities. Yet, the African research landscape faces a myriad of challenges, resulting in a very unequal continent in terms of research and research capacity. The prevailing research inequities and challenges in Africa are even more pronounced in the social sciences, humanities, arts, and related fields (SSHA). Here, the strengths and impact of scholarship in SSHA fields are often overshadowed by deficits and apparent preferential investment in research in science, technology, engineering, and mathematics-related fields. In response, the African Academy of Sciences commissioned a study in 2020 to generate evidence on the SSHA research support landscape in Africa. This paper summarizes findings from the literature review, key informant interviews, a bibliometric analysis, a survey with a sample of 670 respondents from SSHA communities in Africa, and a series of focus group discussions. We highlight key messages and make recommendations focussing on lessons learnt opportunities, and priorities for intervention to enhance significant SSHA research leadership capacity strengthening and, ultimately, minimize research inequalities in Africa.
Influence of Parameters in SDMs Application to Citrus Presence in Mediterranean Area
Authors: Catalano Giuseppe Antonio , D'Urso Provvidenza Rita , Maci Federico , Arcidiacono Claudia
Published: February 2023

In this study, the application of the main algorithms used for SDM, namely Boosted Regression Tree (BRT), Generalized Linear Model (GLM), Multivariate Adaptive Regression Splines (MARS), Maximum Entropy (MAXENT) and Random Forest (RF), were considered in order to simulate the citrus probability of distribution in a Mediterranean area, based on presence data and a random background sample, and in relation to several predictors. The predictors were grouped under 19 bioclimatic variables, elevation described through a Digital terrain model, soil physical properties, and irrigation. Sensitivity analysis was carried out by: modifying the values of the main models’ parameters; and reducing the input presence points.
Minimum Miscibility Pressure and Swelling Factor Determinations of Carbondioxide Gas Injection Applicationin the KHL Oil Field
Authors: Kristanto Dedy , Hariyadi Hariyadi , Agung Yusgiantoro Luky
Published: February 2023

Minimum miscibility pressure (MMP) and oil swelling are two important factors of carbondioxide (CO2) gas displacement mechanism occurred in the reservoir relate to application of CO2 injection in the field to enhance oil recovery. In this paper determination of minimum miscibility pressure (MMP) between crude oil samples with carbondioxide gas conducted using two methods, i.e. correlation methods and laboratory experiment using slimtube. While, determination of swelling factor was conducted using PVT cell, where recombined fluid injected and conditionally at the reservoir temperature. The results of MMP using empirical equation (2807 Psig) and Holm & Josendal correlation (2750 Psig) is more approximate to the result of laboratory analysis (2805 Psig). The result of swelling test during injection CO2 gas processes until 46.82% mole, shows that bubble point pressure is increasing gradually from 410 psig through 2200 psig, and swelling factor was also increase from 1.0 through 1.442. Based on the value of fracture pressure of Layer F in the KHL Field is 2200 Psig and MMP is 2805 Psig, hence the application of CO2 gas injection in the field only could be conducted as immiscible flooding.
Risk Mitigation Strategy In Chicken Distribution System Integration Methodsix Sigma, Root Cause Analysis Dan Swot
Authors: Rizal Mochammad , Sumarmi Wiwik , Bambang Ribangun
Published: February 2023

PT. Behaestex Pandaan is a textile company engaged in the manufacture of Muslim clothing, especially woven sarongs. Weaving sarongs made with ATBM (Not Machine Weaving Equipment) provide the best quality. On the other hand PT. Behaestex Pandaan has provided the best quality but lacks efficiency in terms of factory layout. This research seeks to help make a design proposal for the placement of work stations in order to aim at minimizing the total moment and distance of material transfer due to the condition of the work station having a total moment and distance of movement that is less effective and efficient. This study uses the method of Systematic Layout Planning (SLP) and Blockplan. There are alternative layouts that are possible and then selected to determine the most effective alternative based on the lowest total moment and material displacement distance. In the Systematic Layout Planning (SLP) and Blockplan methods there will be a comparison that can determine the effectiveness of the 2 methods. The Systematic Layout Planning (SLP) method has more granular factors such as workflow and qualitative considerations, while Blockplan is automated only considers a few factors regardless of the current workflow. From the results of this study can find solutions to the problems experienced by PT. Behaestex Pandaan about the proposed layout by comparing the results of the SLP and Blockplan methods so that it can find out the total moment and and distance of material transfer which is more effective and efficient at PT. Behaestex Pandaan.
Proposed Layout Design of Production Facilities Using Group Technology To Improve Utility
Authors: Fahturrohman Dimas Wahyu , Sumarni Wiwik
Published: February 2023

PT. Behaestex Pandaan is a textile industry company in the field of weaving sarong products, at PT. This Behaestex Pandaan needs to regulate the placement of work stations with the aim that there is no unnecessary distance between two adjacent work stations due to unused space and the placement of work stations that affect the relationship of the production process. The method used is using rank order clustering (ROC) and process layout was chosen because as the best production floor layout design proposal that can be used for improvement at PT. Behaestex Pandaan.method Rank order clustering to provide displacement moments to improve the effectiveness of material flow.method Process layout for the preparation and placement of machines or production materials that have a similar model in one division. From the results of this study, it is proposed to be able to find out the best production floor layout proposal and the moment of its displacement, with the results of the initial layout being 16593316.22 meters every year, then using the process layout with the results of 6004001.39 meters every year, and the ROC method with a layout of 5314395.1 meters every year.
Analysis Of Treatment Of Leaf Steel As A Cutting Knife With Quenching Method To Increase Hardness
Authors: Hersandi M. Ganu , Tjahjanti Prantasi Harmi
Published: February 2023

Heat treatment carried out on steel materials will have an effect on the hardness and changes in metal structure in iron or steel. The addition of this hardness depends on the type of steel material used, temperature, and the cooling medium used such as oil, air, and water. In this study, the hardness of the iron cutting knife was increased through a heat treatment process to determine the effect of the hardness of the cutting knife on the result of cutting a 2 mm iron plate. The test object is a cutting knife which will be heated to a temperature of 850°C, cooled using SAE 35 oil. The test results show that the harder the cutting knife, the smaller the angle of inclination of the 2 mm plate..
Upregulation of the long noncoding RNA GJA9-MYCBP and PVT1 is a potential diagnostic biomarker for Acute Lymphoblastic Leukemia
Authors: shahamiri kamal , Alghasi Arash , Saki Najmaldin , teimori Hossein , Kaydani Gholam Abbas , sheikhi Setare
Published: February 2023

Background Acute Lymphoblastic Leukemia (ALL) is the most common type of blood cancer in children. Aberrant expression of long non-coding RNAs may set stages for ALL development. LncRNAs are emerging as a novel diagnostic and prognostic biomarker for ALL. Herein, we aimed to evaluate the expression of lncRNA GJA9-MYCBP and PVT1 in blood samples of ALL and healthy individuals. Methods As a case-control study, 40 pairs of ALL and healthy individual samples were used. The expression ofMYCand each candidate lncRNA was measured using quantitative real-time PCR. Any possible association between the expression of putative non-coding RNAs and clinicopathological characteristics was also evaluated. Results LncRNA GJA9-MYCBP and PVT1 were significantly upregulated in ALL samples compared with healthy ones. Similarly, mRNA levels of MYC were increased in ALL samples than control ones. Receiver operating characteristic curve analysis indicated a satisfactory diagnostic efficacy (P-value < 0.0001), suggesting that lncRNA GJA9-MYCBP and PVT1 may serve as a diagnostic biomarker for ALL. Linear regression analysis unveiled positive correlations between the expression level of MYC and lncRNA GJA9-MYCBP and PVT1 in ALL patients (P-values < 0.01). Conclusions In this study, we provided approval for the clinical diagnostic significance of lncRNA GJA9-MYCBP and PVT1that their upregulations may be a diagnostic biomarker for ALL.
Honeybee colonies change their foraging decisions after in-hive experiences with unsuitable pollens
Authors: Lajad Rocío , Arenas Andrés
Published: February 2023

Pollen is the protein resource for honeybees (Apis mellifera) and its selection affects colony development and productivity. Foragers do not consume pollen at the food source, so we expect pollen components evaluated post-ingestively not to bias their initial foraging preferences. Alternatively, pollen composition could be assessed in a delayed manner, by experiences with the pollens being processed inside the nest or with their effects on the colony. To address whether pollen foraging is mediated by in-hive experiences, we conducted dual-choice experiments to test the avoidance of pollen adulterated with amygdalin, a deterrent that causes post-ingestion malaise. In addition, we recorded pollen selection in colonies foraging in the field after being supplied or not with amygdalin-adulterated pollen from one of the dominant flowering plants (D. tenuifolia). Dual-choice experiments revealed that foragers did not avoid adulterated pollens at the foraging site; however, they could avoid unadulterated pollens that had been offered adulterated within the nest the previous days. In field experiments, pollen samples from colonies supplied with amygdalin-adulterated pollen were more diverse than controls, suggesting that pollen foraging was biased towards novel sources. Our findings support the hypothesis that pollen assessment relies on in-hive experiences mediated by pollen that causes post-ingestive malaise.
A BERT-Span Model for Named Entity Recognition in Rehabilitation Medicine
Authors: Zhong Jinhong , Xuan Zhanxiang , Wang Kang , Cheng Zhou
Published: February 2023

Background.Due to multiple reasons such as the increasing aging of the population and the upgrading of people's health consumption needs, the demand group for rehabilitation medical care is expanding. At present, there are many problems in China's rehabilitation medical care, such as insufficient awareness and shortage of talents. It is especially important to enhance public awareness of rehabilitation and improve the quality of rehabilitation services. Named entity recognition, as the initial task of information processing, can automatically extract rehabilitation medical entities to serve downstream tasks such as information decision system and medical knowledge graph. Methods.To this end, we construct the BERT-Span model to complete the rehabilitation medicine named entity recognition task. First, we collect rehabilitation information from multiple sources to build a corpus in the field of rehabilitation medicine, and fine-tune BERT with the rehabilitation medicine corpus. For rehabilitation medicine text, we use BERT to extract the feature vectors of rehabilitation medicine entities in the text, and use the span model to complete the annotation of rehabilitation medicine entities. Result.Compared to existing baseline models, our model obtained the highest F1 value for the named entity recognition task in the rehabilitation medicine corpus.Conclusions.The experiment results show that our method achieves better results in both long medical entities and nested medical entities recognition in rehabilitation medical texts.
Efficacy and safety of sacubitril/valsartan in patients with heart failure with reduced ejection fraction and hypotension
Authors: Wu Anhu , Lin ZongWei , Yang Zhuohao , Zhang Hui , Hu Jiayi , Wang Yi , Tang Rui , Ji Xiaoping , Lu HuiXia
Published: February 2023

Purpose
It is not clear whether sacubitril/valsartan is beneficial for patients with heart failure with reduced ejection fraction (HFrEF) and low systolic blood pressure (SBP). This study aimed to investigate the efficacy and tolerability of sacubitril/valsartan in HFrEF patients with SBP <100 mmHg under real-world conditions.
Methods and results
An observational study was conducted on 117 patients, 40.2% of whom had SBP <100 mmHg, and 59.8% had SBP ≥100 mmHg. Sacubitril/valsartan target doses were achieved in 52.4% of patients with SBP <100 mmHg and 70.0% of patients with SBP ≥100 mmHg. The effect of sacubitril/valsartan on left ventricular ejection fraction (LVEF) was observed in both SBP categories, with a 10.8% increase in patients with SBP <100 mmHg (P < 0.001) and a 14.0% increase in patients with SBP ≥100 mmHg (P < 0.001). A reduction in the concentration of N-terminal pro-B-type natriuretic peptide (NT-ProBNP) was similar between patients with SBP <100 mmHg and SBP ≥100 mmHg (1627.5 pg/ml and 1340.1 pg/ml, respectively; P = 0.75). The effects of sacubitril/valsartan on SBP were significant inverse across both SBP categories (P = 0.001), with an increase of 7.5 mmHg in patients with SBP<100 mmHg and a reduction of 11.5 mmHg in patients with SBP ≥100 mmHg. There were no significant differences between the two groups in the incidence of symptomatic hypotension, worsening renal function, hyperkalemia, angioedema, or stroke.
Conclusion
In a real-life setting in patients with HFrEF and hypotension, sacubitril/valsartan was generally well tolerated and resulted in left ventricular reverse remodeling.
Microarray expression profile of exosomal circRNAs from high glucose stimulated human renal tubular epithelial cells
Authors: Sha Yan-Hua , Lai Li-Sha , Zhang Lu , Ke Pei-Feng , Yu Ke-Wei , Fang Xiu-Zhu , Deng Ren-Tang , Wan Ze-Min , Wu Xiao-Bin , Han Guang , Jie Yu-Bang , Song Lan-Lan , Huang Xian-Zhang , Fu Wen-Jin
Published: February 2023

Circular RNA (circRNA) is a type of non-coding RNA (ncRNA) with a wealth of functions. Recently, circRNAs have been identified as important regulators of diabetic nephropathy (DN) for their stability and enrichment in exosomes. However, the role of circRNAs from exosome of tubular epithelial cells in DN development has not been fully illustrated. In our study, microarray technology was used to analyze circRNA expression in cell supernatant exosomes isolated from HK-2 cells with or without high glucose (HG) treatment. We found the exosome concentration was higher in HG stimulated HK-2 cells compared with controls. 235 circRNAs were significantly increased and 458 circRNAs were significantly decreased in the exosomes of HG group. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway analysis indicated that circRNA parental genes were associated with glucose metabolism, lipid metabolism and inflammatory process, which are important in DN development. Further analysis of circRNA/miRNA interaction indicated that some differentially expressed circRNAs interacted with one or more binding sites of miRNAs, which are associated with diabetes or DN. In conclusion, our results indicate that exosomal circRNAs may be promising diagnostic and therapeutic biomarkers and play a critical role in the progression of DN.
Comparative analysis of the Potter Tower and a new Track Sprayer for the application of residual sprays in the laboratory
Authors: Bonds Jane , Parsons George , Walker Kyle J. , Lees Rosemary Susan , Nimmo Derric , Clayton John , Murphy Annabel , Malone Dave
Published: February 2023

Efforts to evaluate the residual efficacy of new IRS formulations have identified limitations with the industry standard laboratory sprayer, the Potter Spray Tower (PT). Calibrating the PT can be time-consuming, and the dosing of surfaces may not be as accurate nor uniform as previously assumed. To address these limitations the Micron Horizontal Track Sprayer with Spray Cabinet (TS) was developed to provide higher efficiency, ease of operation, and deposition uniformity equal to or better than the PT. A series of studies showed that deposition volumes could be accurately calibrated for both spray systems. However, the uniformity of spray deposits was higher for the TS compared to the PT. Less than 12% of the volume sprayed using the PT reaches the target surface, with the remaining 88% unaccounted for, presumably vented out of the fume hood or coating the internal surfaces of the tower. In contrast, the TS deposits the majority of the spray on the floor of the spray chamber, with the rest contained therein. The total sprayed surface area in one run of the TS is 1.2 m2, and the operational zone for spray target placement is 0.7 m2, meaning that 58% of the applied volume deposits onto the targets. The TS can treat multiple surfaces (18 standard 15x15 cm tiles) in a single application, whereas the PT treats one surface at a time and a maximum area of around 0.0225m2. An assessment of the time taken to perform spraying, including the setup, calibration and cleaning, showed that the cost of application using the TS was around 25–35× less per tile sprayed. A standard operating procedure (SOP) for calibration and use of both the Potter Tower and Track Sprayer are presented. Overall, the TS represents a significant improvement over the PT in terms of the efficiency and accuracy of IRS formulation applications onto test substrates and offers a useful additional tool for researchers and manufacturers wanting to screen new active ingredients or evaluate the efficacy of IRS or other sprayable formulations for insect control.
Mortality of hospitalized trauma patients in Abu Dhabi Emirate: Data from a National Trauma Registry
Authors: Alao David O. , Cevik Arif Alper , Abu-Zidan Fikri M.
Published: February 2023

Aim
To study the epidemiology and pattern of trauma-related deaths of hospitalised patients in Abu Dhabi, the United Arab Emirates, using the DOH trauma registry of Abu Dhabi in order to improve trauma management and injury prevention.
Methods
Data were retrieved from The Abu Dhabi Trauma Registry which prospectively collects trauma data of all hospitalized patients from 7 major trauma centres in the Abu Dhabi Emirate. We have studied all trauma patients who died on arrival or after admission to these hospitals from January 2014 to December 2019.
Results
There were 453 deaths constituting 13.5% of all trauma deaths in the Abu Dhabi Emirate. 82% of the deaths were young males with a median (IQR) age of 33 (25–45) years. 85% of the deaths occurred in the emergency department (ED) and the intensive care unit (ICU). Motor vehicle collisions (63.8%) and falls (19%), causing mainly head injuries (45.5%) or injuries to two body regions (24.7%), were the two predominant mechanisms. Two out of the seven hospitals admitted close to 50% of all the trauma cases but accounted for only 25.8% of the total deaths, while 75% occurred in the remaining five hospitals (p < 0.001). Those who died in the ward (7%) were significantly older, with a median (IQR) age of 65.5 (31.75–82.25) years (p < 0.001) and 34.4% of them were females (p = 0.09). The median (IQR) GCS of those who died in the ward was 15 (5.75-15) compared with 3 (3–3) for those who died in the ED and ICU (P < 0.001).
Conclusions
Death from trauma predominantly affects young males in our setting. Motor traffic collisions and falls are the two leading causes. Over 85% of hospital deaths occurred in the ICU and ED from head injuries and injuries affecting two body regions. Primary prevention of traffic accidents through legislation and enforcement can mitigate prehospital death, while secondary prevention targeting improved care in the ED and ICU will improve in-hospital mortality.
Impact Evaluation of Biopesticide Adoption on Farmers' Rice Production Efficiency in China
Authors: Lai Xiaoimn , Li Zhaoliang , Zhang Lu , Zhang Junbiao
Published: February 2023

Biopesticides are biologically beneficial to the disease and pest control in agricultural production. However, the traditional view is that biopesticides currently lack economy, making the promotion to farmers in developing countries slow. Based on the perspective of production efficiency under stochastic frontier analysis, we took rice farmers in China as an example to demonstrate the economic effects of biopesticide adoption and its heterogeneity in developing countries. The treatment effect model showed that the adoption had indeed led to an increase in farmers’ productivity, and the external factors, such as cooperatives, plot size, and field culture, as well as their attitude, subjective norms, and perceived behavioural control, contribute to the adoption. Nonlinear regression further indicated the adoption dosage had an inverted u-shaped influence on efficiency, which peaked when biopesticide accounted for 50% of total pesticide input. Moreover, according to quantile regression, the marginal effect of its dosage depended on the efficiency distribution; the more backward the production, the greater the marginal change of efficiency caused by a unit use.
Attosecond Transient Interferometry
Authors: Kneller Omer , Mor Chen , Yaffe Noa , Krüger Michael , Azoury Doron , Federman Yotam , Rajak Debobrata , Bruner Barry , Ivanov Misha (Mikhail) , Smirnova Olga , Patchkovskii Serguei , Mairesse Yann , Dudovich Nirit
Published: February 2023

Attosecond transient absorption resolves the instantaneous response of a quantum system as it interacts with a laser field, by mapping its sub-cycle dynamics onto the absorption spectrum of attosecond pulses. However, the quantum dynamics are imprinted in both amplitude and phase of the attosecond pulses. Here, we introduce attosecond transient interferometry and measure the transient phase, while following its evolution within the optical cycle. We demonstrate how such phase information enables us to decouple the multiple quantum paths induced in a light-driven atom, isolating their coherent contribution. Recording the phase of each quantum path allows us to trace back their temporal evolution, following both resonant and non-resonant excitations. Attosecond transient interferometry has the potential to reveal the sub-cycle dynamics in more complex systems such as molecules and solids, disentangling the role of multiple quantum paths, resolving their coherent properties and coupling mechanisms.
MEDICAL PERSONNEL MANAGEMENT: PLANNING, ANALYSIS, IMPROVEMENT
Authors: Rekunenko Igor , Pavlenko Olena , Omelchenko Andrii , Vasyukova Viktoriia
Published: February 2023

This article summarizes the arguments within the scientific debate on medical personnel management. The main goal is to study the medical personnel management system in three blocks: planning, analysis and improvement of personnel work. The systematization of literary sources and approaches to solving issues of medical personnel management shows that there is a significant range of unsolved problems related precisely to the importance of improving the processes of medical personnel management as a necessary component of the development strategy of the medical industry. The urgency of solving this scientific problem for Ukraine lies in the need to implement reforms in the medical field. In this article, the study of the topic of medical personnel management is carried out in the following logical sequence: in accordance with the set goal, a hypothesis is proved regarding the determination of the interdependence between the effectiveness of the medical institution and the proposed configuration "planning - analysis - improvement" on the example of the Communal Non-Commercial Enterprise of the Sumy Regional Council Regional Diagnostic center in the city of Shostka, which is the object of this study. The methodological toolkit consisted of logical, statistical and empirical methods. In particular, the work presents the results of an empirical analysis of the activity of the medical institution and the formation of directions for improvement of the activity of the studied medical institution based on it. The study empirically confirms and theoretically proves that increasing the efficiency of the medical institution depends on the organization of the medical personnel management process. At the same time, the effectiveness of the personnel management process itself depends on such interrelated components as planning, analysis and improvement of activities. In any personnel composition, there are novice doctors who are gaining experience, and others ⎼ experienced, have problems due to ignorance of modern innovations, in particular in the field of computerization. The main task of the head of a medical institution is to organize, direct and coordinate the activities of all members of the team, to promote the effective work of each member of the team. It is the improvement of the activity of the medical institution that determines the strategic prospects of personnel development. The results of the study can be useful for organizations in the medical field when planning, analyzing and determining areas for improvement of medical personnel management processes.
Prospective Randomized Field Study to Determine the Efficacy of a Serpens spp Vaccine Combined with Topical Treatment with Lincomycin HCl for Treatment of Papillomatous Digital Dermatitis (Footwarts) on a California Dairy
Authors: Berry S. L. , Graham T. W.
Published: February 2023

Fifty-nine cows with active, painful Papillomatous Digital Dermitis (PDD) were randomly assigned to control (n=29) or vaccinate (n=30) groups on day 1. Cows were enrolled in the study based on the presence of a visible lesions on one or both rear heels and a pain response.