bluuebunny/crossref_metadata_2025 huggingface dataset:
Review of Evaluation and Valuation Methods for Cetacean Regulation and Maintenance Ecosystem Services With the Joint Cetacean Protocol Data
Authors: Sheehy Jack Michael , Taylor Nicola L , Zwerschke Nadescha , Collar Mark , Morgan Vicky , Merayo Eugenia
Published: June 2022

Cetaceans provide a range of ecosystem services of value to anthropogenic interests. Following the Common International Classification of Ecosystem Services (CICES) these are categorised as regulation and maintenance, provisioning, and cultural values. This study focuses on those of importance to climate change mitigation through regulation and maintenance. Under regulation and maintenance, cetaceans can store, transport, and influence stocks of carbon through: climate regulation through carbon sequestration, enhanced biodiversity and ecosystem potential, and enhanced primary productivity. ‘Climate regulation through carbon sequestration’ can be quantified as carbon fixation through living biomass and ‘whale-falls’. Cetacean populations store significant stocks of carbon in living biomass. After death, sinking whale carcasses, ‘whale-falls’, provide a significant transfer of biomass and nutrients to benthic sediments and support deep sea ecosystems. During their lifespan, cetaceans also disperse nutrients through feeding and excretion both horizontally through the ‘whale-conveyor’ and vertically through the ‘whale pump’. As nutrient limitations hinder phytoplankton growth, these processes can be quantified as the increased potential of phytoplankton carbon fixation from cetacean driven nutrient cycling. Enhanced biodiversity, ecosystem potential, and primary productivity can be quantified as carbon fixation through nutrient cycling. This study reviews the evaluative and valuative techniques used in cetacean ecosystem service research and adapts and applies them to the Joint Cetacean Protocol (JCP) data which details cetacean abundance and distribution in Europe. They are then reviewed with regards to their robustness, application in markets, and in decision making processes. Cetacean populations are estimated to contain 2 Mt C, cycle 60,000 t N yr-1, and impact carbon fluxes by as much as 22 Mt C yr-1 in the survey area. The values highlight key areas for cetacean conservation: the Outer Hebrides, west of south Wales, around the Isle of Man, to the east of England, and to the north-east of the Shetland Islands. There is, however, large uncertainty in the evaluative processes used; nutrient cycling models presented in this study don’t capture removal of excess nutrients, or the values of enhanced biodiversity and ecosystem potential. As such, they are not sufficiently robust to quantify market values but highlight key areas for future research on climate change mitigation through conservation. Key areas of future research include phytoplankton uptake rates of nitrogen and phosphorus in nutrient limited waters, quantification of ‘enhanced biodiversity and ecosystem potential’, and nutrient removal from coastal waters.
Linking Bacterial Communities to Optical-Derived Properties of Porewater DOM in Sediments in the Coastal East China Sea
Authors: Li Minchun , Xie Wei , Zhang Chuanlun , Yin Kedong
Published: June 2022

Bacterial communities and porewater dissolved organic matter (DOM) pool are intimately interactive in sedimentary environments. Estuarine coastal regions are an interactive area between terrestrial and marine influences in terms of DOM origins and freshness. Yet, we know little about the relationships between the bacterial communities and DOM in those regions. In this study, porewater DOM samples were collected from 42 sites in the coastal East China Sea. The porewater DOM optical properties were determined by fluorescence and absorption spectra, while the corresponding bacterial community compositions of those sediments were examined by 16S rRNA gene high-throughput sequencing. The results showed that bacterial species richness was positively correlated with multiple terrestrial indicators based on the optical properties of DOM, which implied that heterogeneous DOM from terrestrial origins might harbor a wider spectrum of bacterial taxa in marine sediments. The analysis of the co-occurrence network of the bacterial communities showed that the edges and density for samples with low DOM freshness were 3.4 times and 3 times those for the samples with high DOM freshness, respectively. This suggested that the connection among the bacterial taxa under the lower DOM freshness condition were enhanced and that reduced freshness of DOM may encourage more complimentary utilization of resources. The findings provide a new insight into such interactive processes of heterogeneous organic matter utilization meditated by microorganisms in coastal sediments.
Probing Polymer Contact Electrification by Gamma-Ray Radiation
Authors: Zhang Dong Li , Shi Jian Min , Wang Zhong Lin , Tang Wei
Published: June 2022

Triboelectric Nanogenerators (TENGs) have been regarded as an effective method to solve the energy problem since they were first demonstrated in 2012. Due to their high-power generation and low cost, TENGs have been widely applied in the fields of energy, security, biomedicine, the environment, and so on. For now, many researchers are focusing on contact electrification (CE) and surface modification in order to discover the fundamental CE mechanism and approaches to further enhance the performance of TENG devices. In this work, we employ gamma radiation (γ ray) to induce surface modifications on the dielectric materials (polymers in this work) and study its influence on CE. It is found that, due to the high energy of γ ray, some chemical bonds in polymers are destroyed and reformed. This changes the electron density of the polymer molecule, and thus varies the electron transfer ability of the dielectric materials. Afterward, polytetrafluoroethylene (PTFE) and polyvinyl chloride (PVC) become more negative, and polyethylene terephthalate (PET) become the opposite. Kapton, in particular, remains stable even after 1 MGy-dose radiation. This study reconfirms that electron transfer is the dominant process for polymers-related CE. It also suggests that triboelectric nanogenerators could be fabricated with materials possessing a high anti-radiation ability, and used for sensing or energy generation in space or other environments where radiation exists.
Normative Data and Determinants of Macular, Disc, and Peripapillary Vascular Density in Healthy Myopic Children Using Optical Coherence Tomography Angiography
Authors: Chen Ruru , Lian Hengli , McAlinden Colm , Skiadaresi Eirini , Liu Siyu , Wan Ting , Diao Kai , Pan Hongxian , Qu Jia , Huang Jinhai , Li Yiyu
Published: June 2022

Objective

To establish a normative database for the vascular density (VD) in macular, disc, and peripapillary regions in healthy myopic children and to evaluate associated ocular features with optical coherence tomography angiography (OCTA).

Methods

This was an observational, prospective and cross-sectional study. 776 Chinese healthy myopic children (375 boys and 401 girls) were enrolled, mean (±SD) age 9.84 ± 1.98 (range 6–16) years. En-face angiogram OCTA was performed on 6 mm × 6 mm retinal and 4.5 mm × 4.5 mm disc regions. VD measurements in the macular retina were segmented into the four regions: superficial capillary plexus (SCP), intermediate capillary plexus (ICP), deep capillary plexus (DCP), and choriocapillaris (CC). Correlations between macular, disc, and peripapillary VD and possible influencing factors [age, gender, axial length (AL), spherical equivalent refraction (SER), right/left eye, and signal strength index (SSI)] were assessed by Pearson’s correlation and multivariate regression analysis.

Results

For macular scans, the corrected VD in the ICP region was (48.25 ± 4.24)% for the whole macular retina. The macular ICP VD in most sections was lower than the SCP, DCP, and CC (all P < 0.001). The corrected VD in CC was (72.96 ± 4.42)% for the whole macular retina. The macular CC VD in every section was all higher than the SCP, ICP, and DCP (all P < 0.001). The size of foveal avascular zone (FAZ) and foveal VD 300 (FD-300) was 0.28 mm2± 0.10 mm2 and (58.43 ± 4.17)% respectively. For disc scans, the corrected VD was (58.04 ± 2.73)% for the whole disc area. Both AL and SER were strongly correlated with ICP, DCP, and CC VD in all regions (all P < 0.01). Larger SSI was correlated with a lower VD in the SCP and ICP, and a higher VD in DCP and CC (all P < 0.01).

Conclusion

Vascular density values provide large scale normative data on macular, disc, and peripapillary vascular parameters in a large sample of healthy myopic children with OCTA measured in the four different retinal plexuses and regions. The VD in different regions had various influencing factors; mainly a close correlation with AL and SSI.
CD8+ T-Cells in Juvenile-Onset SLE: From Pathogenesis to Comorbidities
Authors: Ciurtin Coziana , Pineda-Torra Ines , Jury Elizabeth C. , Robinson George A.
Published: June 2022

Diagnosis of systemic lupus erythematosus (SLE) in childhood [juvenile-onset (J) SLE], results in a more severe disease phenotype including major organ involvement, increased organ damage, cardiovascular disease risk and mortality compared to adult-onset SLE. Investigating early disease course in these younger JSLE patients could allow for timely intervention to improve long-term prognosis. However, precise mechanisms of pathogenesis are yet to be elucidated. Recently, CD8+ T-cells have emerged as a key pathogenic immune subset in JSLE, which are increased in patients compared to healthy individuals and associated with more active disease and organ involvement over time. CD8+ T-cell subsets have also been used to predict disease prognosis in adult-onset SLE, supporting the importance of studying this cell population in SLE across age. Recently, single-cell approaches have allowed for more detailed analysis of immune subsets in JSLE, where type-I IFN-signatures have been identified in CD8+ T-cells expressing high levels of granzyme K. In addition, JSLE patients with an increased cardiometabolic risk have increased CD8+ T-cells with elevated type-I IFN-signaling, activation and apoptotic pathways associated with atherosclerosis. Here we review the current evidence surrounding CD8+ T-cell dysregulation in JSLE and therapeutic strategies that could be used to reduce CD8+ T-cell inflammation to improve disease prognosis.
Design and Verification of a Novel Perfusion Bioreactor to Evaluate the Performance of a Self-Expanding Stent for Peripheral Artery Applications
Authors: Nandan Swati , Schiavi-Tritz Jessica , Hellmuth Rudolf , Dunlop Craig , Vaughan Ted J. , Dolan Eimear B.
Published: June 2022

Endovascular stenting presents a promising approach to treat peripheral artery stenosis. However, a significant proportion of patients require secondary interventions due to complications such as in-stent restenosis and late stent thrombosis. Clinical failure of stents is not only attributed to patient factors but also on endothelial cell (EC) injury response, stent deployment techniques, and stent design. Three-dimensional in vitro bioreactor systems provide a valuable testbed for endovascular device assessment in a controlled environment replicating hemodynamic flow conditions found in vivo. To date, very few studies have verified the design of bioreactors based on applied flow conditions and their impact on wall shear stress, which plays a key role in the development of vascular pathologies. In this study, we develop a computationally informed bioreactor capable of capturing responses of human umbilical vein endothelial cells seeded on silicone tubes subjected to hemodynamic flow conditions and deployment of a self-expanding nitinol stents. Verification of bioreactor design through computational fluid dynamics analysis confirmed the application of pulsatile flow with minimum oscillations. EC responses based on morphology, nitric oxide (NO) release, metabolic activity, and cell count on day 1 and day 4 verified the presence of hemodynamic flow conditions. For the first time, it is also demonstrated that the designed bioreactor is capable of capturing EC responses to stent deployment beyond a 24-hour period with this testbed. A temporal investigation of EC responses to stent implantation from day 1 to day 4 showed significantly lower metabolic activity, EC proliferation, no significant changes to NO levels and EC's aligning locally to edges of stent struts, and random orientation in between the struts. These EC responses were indicative of stent-induced disturbances to local hemodynamics and sustained EC injury response contributing to neointimal growth and development of in-stent restenosis. This study presents a novel computationally informed 3D in vitro testbed to evaluate stent performance in presence of hemodynamic flow conditions found in native peripheral arteries and could help to bridge the gap between the current capabilities of 2D in vitro cell culture models and expensive pre-clinical in vivo models.
Codon Usage of Hepatitis E Viruses: A Comprehensive Analysis
Authors: Li Bingzhe , Wu Han , Miao Ziping , Hu Linjie , Zhou Lu , Lu Yihan
Published: June 2022

Hepatitis E virus (HEV) is an emerging zoonotic pathogen with multiple species and genotypes, which may be classified into human, animal, and zoonotic HEV. Codon usage bias of HEV remained unclear. This study aims to characterize the codon usage of HEV and elucidate the main drivers influencing the codon usage bias. A total of seven HEV genotypes, HEV-1 (human HEV), HEV-3 and HEV-4 (zoonotic HEV), HEV-8, HEV-B, HEV-C1, and HEV-C2 (emerging animal HEV), were included in the study. Complete coding sequences, ORF1, ORF2, and ORF3, were accordingly obtained in the GenBank. Except for HEV-8, the other six genotypes tended to use codons ending in G/C. Based on the analysis of relatively synonymous codon usage (RSCU) and principal component analysis (PCA), codon usage bias was determined for HEV genotypes. Codon usage bias differed widely across human, zoonotic, and animal HEV genotypes; furthermore, it varied within certain genotypes such as HEV-4, HEV-8, and HEV-C1. In addition, dinucleotide abundance revealed that HEV was affected by translation selection to form a unique dinucleotide usage pattern. Moreover, parity rule 2 analysis (PR2), effective codon number (ENC)-plot, and neutrality analysis were jointly performed. Natural selection played a leading role in forming HEV codon usage bias, which was predominant in HEV-1, HEV-3, HEV-B and HEV-C1, while affected HEV-4, HEV-8, and HEV-C2 in combination with mutation pressure. Our findings may provide insights into HEV evolution and codon usage bias.
Relationship Between Arterial Stiffness Index, Pulse Pressure, and Magnetic Resonance Imaging Markers of White Matter Integrity: A UK Biobank Study
Authors: Badji Atef , Cohen-Adad Julien , Girouard Hélène
Published: June 2022

Background

Alzheimer’s disease and dementia in general constitute one of the major public health problems of the 21st century. Research in arterial stiffness and pulse pressure (PP) play an important role in the quest to reduce the risk of developing dementia through controlling modifiable risk factors.

Objective

The aim of the study is to investigate the association between peripheral PP, arterial stiffness index (ASI) and brain integrity, and to discover if ASI is a better predictor of white matter integrity than peripheral PP.

Materials and Methods

17,984 participants 63.09 ± 7.31 from the UK Biobank were used for this study. ASI was estimated using infrared light (photoplethysmography) and peripheral PP was calculated by subtracting the diastolic from the systolic brachial blood pressure value. Measure of fractional anisotropy (FA) was obtained from diffusion imaging to estimate white matter microstructural integrity. White matter hyperintensities were segmented from the combined T1 and T2-weighted FLAIR images as a measure of irreversible white matter damage.

Results

An important finding is that peripheral PP better predicts white matter integrity when compared to ASI. This finding is consistent until 75 years old. Interestingly, no significant relationship is found between either peripheral PP or ASI and white matter integrity after 75 years old.

Conclusion

These results suggest that ASI from plethysmography should not be used to estimate cerebrovascular integrity in older adults and further question the relationship between arterial stiffness, blood pressure, and white matter damage after the age of 75 years old.
Am I (Deep) Blue? Music-Making AI and Emotional Awareness
Authors: Novelli Nicholas , Proksch Shannon
Published: June 2022

Artificial Intelligence has shown paradigmatic success in defeating world champions in strategy games. However, the same programming tactics are not a reasonable approach to creative and ostensibly emotional artistic endeavors such as music composition. Here we review key examples of current creative music generating AIs, noting both their progress and limitations. We propose that these limitations are rooted in current AIs lack of thoroughly embodied, interoceptive processes associated with the emotional component of music perception and production. We examine some current music-generating machines that appear to be minimally addressing this issue by appealing to something akin to interoceptive processes. To conclude, we argue that a successful music-making AI requires both the generative capacities at which current AIs are constantly progressing, and thoroughly embodied, interoceptive processes which more closely resemble the processes underlying human emotions.
Dexmedetomidine Inhibits Gasdermin D-Induced Pyroptosis via the PI3K/AKT/GSK3β Pathway to Attenuate Neuroinflammation in Early Brain Injury After Subarachnoid Hemorrhage in Rats
Authors: Wei Boyang , Liu Wenchao , Jin Lei , Guo Shenquan , Fan Haiyan , Jin Fa , Wei Chengcong , Fang Dazhao , Zhang Xin , Su Shixing , Duan Chuanzhi , Li Xifeng
Published: June 2022

Subarachnoid hemorrhage (SAH) is one kind of life-threatening stroke, which leads to severe brain damage. Pyroptosis plays a critical role in early brain injury (EBI) after SAH. Previous reports suggest that SAH-induced brain edema, cell apoptosis, and neuronal injury could be suppressed by dexmedetomidine (Dex). In this study, we used a rat model of SAH to investigate the effect of Dex on pyroptosis in EBI after SAH and to determine the mechanisms involved. Pyroptosis was found in microglia in EBI after SAH. Dex significantly alleviated microglia pyroptosis via reducing pyroptosis executioner GSDMD and inhibited the release of proinflammatory cytokines induced by SAH. Furthermore, the reduction of GSDMD by Dex was abolished by the PI3K inhibitor LY294002. In conclusion, our data demonstrated that Dex reduces microglia pyroptosis in EBI after SAH via the activation of the PI3K/AKT/GSK3β pathway.
Considerations for Selecting Cognitive Endpoints and Psychological Patient-Reported Outcomes for Clinical Trials in Pediatric Patients With Sickle Cell Disease
Authors: Hood Anna M. , Crosby Lori E. , Stotesbury Hanne , Kölbel Melanie , Kirkham Fenella J.
Published: June 2022

Pediatric patients with sickle cell disease (SCD) experience a range of medical complications that result in significant morbidity and mortality. Recent advances in prophylactic and curative treatment approaches have highlighted the need for sensitive and clinically-meaningful trial endpoints. The detrimental effects of cognitive and psychological difficulties on social and economic mobility are well described. Although numerous reviews have assessed cognitive outcomes in other rare genetic disorders, SCD has not received the same focus. This review describes the cognitive (i.e., executive function and processing speed) and psychological domains (i.e., depression and anxiety) that are consistently associated with SCD pathology and, therefore, may be of particular interest as clinical trial endpoints. We then discuss corresponding well-validated and reliable cognitive tests and patient-reported outcomes (PROs) that may be appropriate for clinical trials given their robust psychometric properties, ease of administration, and previous use in the SCD population. Further, we provide a discussion of potential pitfalls and considerations to guide endpoint selection. In line with the move toward patient-centered medicine, we identify specific tests (e.g., NIH Toolbox Cognition Module, Wechsler Cancellation Test) and psychological PROs (e.g., PROMIS depression and anxiety scales) that are sensitive to SCD morbidity and have the potential to capture changes that are clinically meaningful in the context of patients' day to day lives. In particularly vulnerable cognitive domains, such as executive function, we highlight the advantages of composite over single-test scores within the context of trials. We also identify general (i.e., practice effects, disease heterogeneity) and SCD-specific considerations (i.e., genotype, treatment course, and disease course, including degree of neurologic, pain, and sleep morbidity) for trial measures. Executive function composites hold particular promise as trial endpoints that are clinically meaningful, amenable to change, relatively easy to collect, and can be incorporated into the routine care of patients with SCD in various settings and countries.
Research Hotspots and Effectiveness of Transcranial Magnetic Stimulation in Pain: A Bibliometric Analysis
Authors: Li Chong , Sun Mingyu , Tian Shiliu
Published: June 2022

Transcranial magnetic stimulation, as a relatively new type of treatment, is a safe and non-invasive method for pain therapy. Here, we used CiteSpace software to visually analyze 440 studies concerning transcranial magnetic stimulation in pain research from 2010 to 2021, indexed by Web of Science, to clarify the research hotspots in different periods and characterize the process of discovery in this field. The United States ranked first in this field. Lefaucheur JP, Fregni F, and Andrade ACD made great contributions to this field of study. The most prolific institution was University of São Paulo. The four main hot keywords were neuropathic pain, motor cortex, connectivity, and non-invasive brain stimulation. There were three main points that were generally accepted: (1) definite analgesic effect of high-frequency rTMS of M1 contralateral to pain side in neuropathic pain; (2) there are inconclusive recommendations regarding rTMS of the dorsolateral prefrontal cortex (DLPFC) in fibromyalgia and neuropathic pain; (3) there is low-quality evidence that single doses of high-frequency rTMS of the motor cortex may have short-term effects on chronic pain. This bibliometric analysis indicated that prospective, multi-center, large-sample, randomized controlled trials are still needed to further verify the effectiveness of various transcranial magnetic stimulation parameters in pain research.
The Causal Effects of Lipid Profiles on Sleep Apnea
Authors: Tang Hongyi , Zhou Qing , Zheng Fu , Wu Tong , Tang Yi-Da , Jiang Jiuhui
Published: June 2022

Introduction

Observational studies have suggested that lipid profiles were associated with risk of sleep apnea (SA). However, the specific lipid types and whether this relationship has a causal effect are uncertain. This study conducted two-sample Mendelian randomization (MR) and multivariable Mendelian randomization (MVMR) to investigate the potential causal relationship between lipid profiles and risk of SA.

Materials and Methods

We used the largest genome-wide association study (GWAS) on European participants on the UK Biobank. After a rigorous single nucleotide polymorphism screening process to remove confounding effects, we performed MR and MVMR to explore the causal relationship between lipid profiles and SA risk.

Results

Both MR and MVMR showed causal effects of increased triglyceride on SA risk [MR: per 10 units, odds ratio (OR): 1.0156; 95% CI: 1.0057–1.0257; P value = 0.002; MVMR: per 10 units, OR: 1.0229; 95% CI: 1.0051–1.0411; P value = 0.011]. The sensitivity analysis including Cochran’s Q test, MR-Egger intercept, and MR pleiotropy residual sum and outlier (MR-PRESSO) test indicated that our findings were robust. The causal effects of triglyceride on SA did not change after adjusting for potential confounders (obesity, age, sex, and airway obstruction).

Conclusion

Genetically increased triglyceride levels have independent causal effects on risk of sleep apnea without the confounding effects of obesity, suggesting that lowering triglyceride concentrations may help to reduce the risk of sleep apnea.
Surgical Methods and Social Factors Are Associated With Long-Term Survival in Follicular Thyroid Carcinoma: Construction and Validation of a Prognostic Model Based on Machine Learning Algorithms
Authors: Mao Yaqian , Huang Yanling , Xu Lizhen , Liang Jixing , Lin Wei , Huang Huibin , Li Liantao , Wen Junping , Chen Gang
Published: June 2022

Background

This study aimed to establish and verify an effective machine learning (ML) model to predict the prognosis of follicular thyroid cancer (FTC), and compare it with the eighth edition of the American Joint Committee on Cancer (AJCC) model.

Methods

Kaplan-Meier method and Cox regression model were used to analyze the risk factors of cancer-specific survival (CSS). Propensity-score matching (PSM) was used to adjust the confounding factors of different surgeries. Nine different ML algorithms,including eXtreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (LightGBM), Random Forests (RF), Logistic Regression (LR), Adaptive Boosting (AdaBoost), Gaussian Naive Bayes (GaussianNB), K-Nearest Neighbor (KNN), Support Vector Machine (SVM) and Multi-Layer Perceptron (MLP),were used to build prognostic models of FTC.10-fold cross-validation and SHapley Additive exPlanations were used to train and visualize the optimal ML model.The AJCC model was built by multivariate Cox regression and visualized through nomogram. The performance of the XGBoost model and AJCC model was mainly assessed using the area under the receiver operating characteristic (AUROC).

Results

Multivariate Cox regression showed that age, surgical methods, marital status, T classification, N classification and M classification were independent risk factors of CSS. Among different surgeries, the prognosis of one-sided thyroid lobectomy plus isthmectomy (LO plus IO) was the best, followed by total thyroidectomy (hazard ratios: One-sided thyroid LO plus IO, 0.086[95% confidence interval (CI),0.025-0.290], P<0.001; total thyroidectomy (TT), 0.490[95%CI,0.295-0.814], P=0.006). PSM analysis proved that one-sided thyroid LO plus IO, TT, and partial thyroidectomy had no significant differences in long-term prognosis. Our study also revealed that married patients had better prognosis than single, widowed and separated patients (hazard ratios: single, 1.686[95%CI,1.146-2.479], P=0.008; widowed, 1.671[95%CI,1.163-2.402], P=0.006; separated, 4.306[95%CI,2.039-9.093], P<0.001). Among different ML algorithms, the XGBoost model had the best performance, followed by Gaussian NB, RF, LR, MLP, LightGBM, AdaBoost, KNN and SVM. In predicting FTC prognosis, the predictive performance of the XGBoost model was relatively better than the AJCC model (AUROC: 0.886 vs. 0.814).

Conclusion

For high-risk groups, effective surgical methods and well marital status can improve the prognosis of FTC. Compared with the traditional AJCC model, the XGBoost model has relatively better prediction accuracy and clinical usage.
Cost-Effectiveness of Lenvatinib Plus Pembrolizumab or Everolimus as First-Line Treatment of Advanced Renal Cell Carcinoma
Authors: Wang Ye , Wang Hao , Yi Manman , Han Zhou , Li Li
Published: June 2022

Background

In this study, compared to sunitinib as one of the available treatment options, we aimed to evaluate the cost-effectiveness of lenvatinib plus pembrolizumab or everolimus as first-line treatment for advanced renal cell carcinoma (RCC) patients in a Chinese health system setting.

Methods

A partitioned survival model was developed to simulate patient disease and death. Transition probabilities and adverse reaction data were obtained from the CLEAR trial. The utility value was derived from literature. Costs were based on the Chinese drug database and local charges. Sensitivity analyses and were performed to assess the robustness of the model. Outcomes were measured as quality-adjusted life-years (QALYs), cumulative cost (COST), and incremental cost-effectiveness ratio (ICER).

Results

The model predicted that the expected mean result in the lenvatinib plus pembrolizumab group (2.60 QALYs) was superior to that in the sunitinib group (2.13 QALYs) to obtain 0.47 QALYs, but the corresponding cost was 1,253,130 yuan greater, resulting in an ICER of 2,657,025 RMB/QALYs. Compared with the sunitinib group, the lenvatinib plus everolimus group (2.17 QALYs) gained 0.04 QALYs, with an additional cost of 32,851 yuan, resulting in an ICER of 77,6202 RMB/QALYs.

Conclusions

Lenvatinib plus pembrolizumab or everolimus has no economic advantage over sunitinib in treating advanced RCC in the Chinese healthcare system.
Helicobacter pylori Infection Is Associated With Thyroid Dysfunction in Children With Congenital Hypothyroidism
Authors: Silva Ivani Novato , Marçal Lara Vieira , Queiroz Dulciene Maria Magalhães
Published: June 2022

Helicobacter pylori (H. pylori) infection leads to a systemic low-grade inflammatory state and has been associated causally with a diverse spectrum of extra-gastric disorders. Among them, the infection has been involved in the pathogenesis of autoimmune thyroid disease (ATD), but only one study had evaluated children. Therefore, a cross-sectional study was conducted in a cohort of 142 children and adolescents, randomly assessed among those followed up for thyroid diseases in a university pediatric endocrinology service: 106 with congenital hypothyroidism (CH) and 36 with ATD. All children were asymptomatic, under strict control on levothyroxine replacement, and reported no other diseases or use of drugs. Helicobacter pylori status was evaluated by the 13C-Urea Breath Test (13C-UBT). Antithyroid antibodies (ATPO, antiTg, and TRAb) and serum thyroid hormones (TSH, free T4, and T3) were assessed by standard assays. Data were analyzed in logistic models by the SPSS statistical software package, and a p-value ≤ 0.05 was considered statistically significant. The prevalence of H. pylori infection was 19.44% in children with ATD. Neither the gender nor the serum levels of thyroid hormones and antithyroid antibodies were associated with the H. pylori-positive status. Thirty-seven (34.90%) children with CH were infected with H. pylori. The mean T3 serum level (3.59 ± 0.84) was significantly lower (p = 0.001) in the infected children than in those free from the infection (3.95 ± 0.89), association that remained after adjustment for the other variables in the multivariate analysis. Because no difference was observed in the levels of TSH and T4, the results indicate that the infection may lead to impairment in the thyroid hormonal balance, but not in the hypothalamic-pituitary-thyroid axis function. In as much as H. pylori infection is highly widespread and the prevalence of CH is also not negligible, additional studies are required to confirm our results and to identify the involved mechanisms.
Cannabidiol-Treated Ovariectomized Mice Show Improved Glucose, Energy, and Bone Metabolism With a Bloom in Lactobacillus
Authors: Sui Ke , Tveter Kevin M. , Bawagan Fiona G. , Buckendahl Patricia , Martinez Savannah A. , Jaffri Zehra H. , MacDonell Avery T. , Wu Yue , Duran Rocio M. , Shapses Sue A. , Roopchand Diana E.
Published: June 2022

Loss of ovarian 17β-estradiol (E2) in postmenopause is associated with gut dysbiosis, inflammation, and increased risk of cardiometabolic disease and osteoporosis. The risk-benefit profile of hormone replacement therapy is not favorable in postmenopausal women therefore better treatment options are needed. Cannabidiol (CBD), a non-psychotropic phytocannabinoid extracted from hemp, has shown pharmacological activities suggesting it has therapeutic value for postmenopause, which can be modeled in ovariectomized (OVX) mice. We evaluated the efficacy of cannabidiol (25 mg/kg) administered perorally to OVX and sham surgery mice for 18 weeks. Compared to VEH-treated OVX mice, CBD-treated OVX mice had improved oral glucose tolerance, increased energy expenditure, improved whole body areal bone mineral density (aBMD) and bone mineral content as well as increased femoral bone volume fraction, trabecular thickness, and volumetric bone mineral density. Compared to VEH-treated OVX mice, CBD-treated OVX mice had increased relative abundance of fecal Lactobacillus species and several gene expression changes in the intestine and femur consistent with reduced inflammation and less bone resorption. These data provide preclinical evidence supporting further investigation of CBD as a therapeutic for postmenopause-related disorders.
Risk Factors Associated With Prolonged Antibiotic Use in Pediatric Bacterial Meningitis
Authors: He Cuiyao , Hu Xiaogang , Li Tingsong , Wu Qing , Fan Jisan , Zhou Yan , Jiang Li , Hong Siqi , Luo Yuanyuan
Published: June 2022

Objectives: To determine the risk factors associated with a prolonged antibiotic course for community-acquired bacterial meningitis (BM) in children.

Methods: This retrospective cohort study included children aged 1 month to 18 years with community-acquired BM due to a confirmed causative pathogen from 2011 to 2021. Patients were divided into an antibiotic prolongation group and a nonprolongation group according to whether the antibiotic course exceeded 2 weeks of the recommended course for the causative pathogen. Associations of important clinical characteristics and laboratory and other parameters with antibiotic prolongation were assessed using univariate and multivariable regression logistic analyses.

Results: In total, 107 patients were included in this study. Augmented renal clearance (ARC) (OR, 19.802; 95% CI, 7.178–54.628; p < 0.001) was associated with a prolonged antibiotic course; however, septic shock, causative pathogen, preadmission antibiotic use, peripheral white blood cell (WBC) count, initial cerebrospinal fluid (CSF) WBC count, CSF glucose, CSF protein, and surgical intervention were not associated with the prolonged antibiotic course. Patients with ARC had more total fever days (median time: 14 vs. 7.5 days), longer hospitalization (median time: 39 vs. 24 days), higher rates of complications (72.34% vs. 50.00%) and antibiotic adjustments (78.723% vs. 56.667%) than patients with normal renal function.

Conclusion: ARC is an independent risk factor for prolonged antibiotic use in children with community-acquired BM. ARC may be associated with longer fever and hospitalization durations, higher rates of complications and antibiotic adjustments.
A Substantial Role of Agro-Textiles in Agricultural Applications
Authors: Sharma Neha , Allardyce Ben , Rajkhowa Rangam , Adholeya Alok , Agrawal Ruchi
Published: June 2022

Agro-textiles have been used in the agriculture sector for thousands of years and are an attractive tool for the protection of crops during their entire lifecycle. Currently, the agro-textile market is dominated by polyolefins or petrochemical-based agro-textiles. However, climate change and an increase in greenhouse gas emissions have raised concern about the future oil-based economy, and petroleum-based agro-textiles have become expensive and less desirable in the modern world. Other products include agro-textiles based on natural fibers which degrade so fast in the environment that their recovery from the field becomes difficult and unattractive even by efficient recycling or combustion, and their lifetime is usually limited to 1 or a maximum of 2 years. Hence, the development of bio-based agro-textiles with a reduced impact on the environment and with extended durability is foreseen to initiate the growth in the bio-based economy. The world is gradually preparing the shift toward a bio-based economy, and research for sustainable bio-based alternatives has already been initiated. This review provides insight into the various agro-textiles used currently in agriculture and the research going on in the area of agro-textiles to offer alternative solutions to the current agro-textile market.
Associations Between Relative Deprivation and Life Satisfaction During the COVID-19 Lockdown: Results of Serial Mediation Analyses
Authors: Chen Junbo , Cao Jun , Fu Shuying , Jia Xuji
Published: June 2022

With the COVID-19 pandemic, life satisfaction among college students has become a key issue at universities and in society. The current study explores the effects of belief in a just world and resilience on the relationship between relative deprivation and life satisfaction. A total of 787 college students from universities in China completed online questionnaires. Results showed that relative deprivation was negatively correlated with life satisfaction. Belief in a just world and resilience separately mediated the relationship between relative deprivation and life satisfaction. Moreover, a serial mediating effect of belief in a just world and resilience was observed between relative deprivation and life satisfaction. These findings suggest that relative deprivation may impair individuals' beliefs in a just world. Moreover, less belief in a just world may lower resilience and consequently decrease life satisfaction. This study enriches the research field of relative deprivation theory in the context of the COVID-19 pandemic, and provides a new interpretation and intervention perspective for improving college students' life satisfaction.
National Ballad Creation Education Under Artificial Intelligence and Big Data
Authors: Liu Xia , Han Xiao , Lin Xiao , Yang Jong Hoon
Published: June 2022

The efficiency of manual ballad creation is low, and the status quo of music creation education still needs to be improved. Therefore, how to upgrade the creative level of students is studied to improve the creative ability of China’s unique ballad culture. The concept of music theory in the process of music creation is explained, and the application of big data in the NetEase cloud music platform is excavated. Besides, the optical music organization (OMR) method based on artificial intelligence (AI) is proposed using a learning method of style imitation. This method is applied to students’ ballad creation education and tested in the school creation curriculum. It is found that the novelty of the ballads created by the system is slightly better than the existing ballads by comparing the ballads created by the machine with those used as imitation templates. In addition, the students’ learning interests and creative achievement are compared through the comparative experiment. The results show that students’ interest in learning has been significantly improved, and their creative performance in oral language has also been enhanced compared with the control class. As a result, this system is considered to be able to be applied in students’ ballad creation courses and provide some basis for AI creation in related fields.
Effects of Multimedia Assisted Song Integrated Teaching on College Students' English Learning Interests and Learning Outcomes
Authors: Luo Yu-Zhou , Kong Xiang-Yang , Ma Yu-Yang
Published: June 2022

In the process of globalization, the English language not only represents British and American culture, but it has also gradually become a language used all over the world, and it has become essential for many people to learn it as a second language. Education is the century business of a nation. At the same time, to meet the needs of E generation, I generation, and touch-screen generation students, teachers are increasingly undertaking multimedia-integrated curriculum design and instruction. Teachers are no longer knowledge providers, but they are expected to provide students with a personalized learning model and guide and support them in a timely manner. This study included a sample of business students from Guilin University of technology. A total of 216 students participated in a 16-week (3 h per week, a total of 48 h) course of experimental teaching. The research results showed that 1. multimedia assisted, song integrated English teaching affected learning interest, 2. That multimedia assisted, song integrated English teaching affected learning outcomes, and 3. That learning interest had significantly positive effects on learning outcome. Based on these results, this study contributes to improving college students' English listening, speaking, reading, and writing skills via multimedia teaching, which also facilitated their interest and ability to achieve the learning outcomes.
Prevalence of Metabolic Syndrome and Insulin Resistance in a Sample of Adult ADHD Outpatients
Authors: di Girolamo Giulia , Bracco Irene Francesca , Portigliatti Pomeri Alberto , Puglisi Soraya , Oliva Francesco
Published: June 2022

Background

High prevalence of Metabolic Syndrome (MS) was found in patients with schizophrenia and bipolar disorders. Insulin Resistance (IR) seems to mediate MS role in developing cardiometabolic consequences.

Aims

To investigate the prevalence of MS, and the role of MS components and IR surrogate indexes in determining MS in adult ADHD outpatients.

Methods

In the present cross-sectional study, MS, defined according to the Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (ATP III), and IR surrogate indexes were assessed on a consecutive sample of adult ADHD outpatients. Logistic regression analysis was performed to evaluate the effect of each ATP III component and IR surrogate index in determining MS.

Results

Seventeen out of 158 patients (10.8%, 95%CI = 0.064/0.167) fulfilled the ATP-III criteria for MS. A comprehensive comparison with prevalence in the reference population was hindered by the lack of patients over 60 in the study sample, however under this age no significant differences were found. Among MS components, blood triglycerides level (OR = 1.02, 95%CI=1.01/1.03, p = 0.001) was the main predictor for MS, followed by diastolic blood pressure (OR = 1.08, 95%CI=1.01/1.16, p = 0.024) and waist circumference (OR = 1.06, 95%CI=1.01/1.13, p = 0.029). Lipid Accumulation Product (LAP, OR = 1.0006, 95%CI=1.0003/1.0009, p < 0.001) outperformed Triglyceride-Waist Circumference (TG-WC, OR=1.03, 95%CI=1.01/1.04, p < 0.001) in predicting MS.

Conclusions

More attention should be paid not only to MS but also to each ATP III component of MS and LAP in ADHD patients both at first assessment and during follow-up process.
Experiences Using a Multidisciplinary Model for Treating Injection Drug Use Associated Infections: A Qualitative Study
Authors: Nolan Nathanial S. , Gleason Emily , Marks Laura R. , Habrock-Bach Tracey , Liang Stephen Y. , Durkin Michael J.
Published: June 2022

Background

Over the past two decades, the United States has experienced a dramatic increase in the rate of injection drug use, injection associated infections, and overdose mortality. A hospital-based program for treating opioid use disorder in people who inject drugs presenting with invasive infections was initiated at an academic tertiary care center in 2020. The goal of this program was to improve care outcomes, enhance patient experiences, and facilitate transition from the hospital to longer term addiction care. The purpose of this study was to interview two cohorts of patients, those admitted before vs. after initiation of this program, to understand the program's impact on care from the patient's perspective and explore ways in which the program could be improved.

Methods

Thirty patients admitted to the hospital with infectious complications of injection drug use were interviewed using a semi-structured format. Interviews were transcribed and coded. Emergent themes were reported. Limited descriptive statistics were reported based on chart review.

Results

Thirty interviews were completed; 16 participants were part of the program (admitted after program implementation) while 14 were not participants (admitted prior to implementation). Common themes associated with hospitalization included inadequate pain control, access to medications for opioid use disorder (MOUD), loss of freedom, stigma from healthcare personnel, and benefits of having an interprofessional team. Participants in the program were more likely to report adequate pain control and access to MOUD and many cited benefits from receiving care from an interprofessional team.

Conclusions

Patients with opioid use disorder admitted with injection related infections reported improved experiences when receiving care from an interprofessional team focused on their addiction. However, perceived stigma from healthcare personnel and loss of freedom related to hospitalization were continued barriers to care before and after implementation of this program.
Social Support and Diabetes Management Among Older American Indians
Authors: Goins R. Turner , Grant Molly K. , Conte Kathleen P. , Lefler Lisa
Published: June 2022

Objective

Greater understanding how relationships that can facilitate or impede type 2 diabetes (T2D) management and control among older American Indian people is an overlooked, yet urgently needed strategy. Thus, we examined social support among older American Indian people in relation to their T2D management.

Methods

During the fall 2015, we conducted qualitative interviews with 28 participants aged ≥ 60 years who were members of a federally-recognized tribe. Drawing upon the buffering and direct effects theoretical models of how social support affects health, we examined transcribed audio recordings of the interviews with a systematic text analysis approach. We used a low-inference qualitative descriptive design to provide a situated understanding of participants' life experiences using their naturalistic expressions.

Results

The mean age of our participants was 73.0 ± 6.4 years with a mean HbA1c of 7.3 ± 1.5. Main social support sources were family, clinicians/formal services, community/culture, and spiritual/God. All four common social support types were represented, namely emotional, instrumental, informational, and appraisal support with most being instrumental in nature. A prominent gender difference was seen with respect to men receiving more instrumental support family/friends support than women.

Discussion

Value orientations among American Indian people often reflect extended social systems and interdependence. A deeper understanding is needed of how social relationships can be better leveraged to aid in effective T2D management among older American Indian people. The development and implementation of evidence-based social network interventions with an assets-based orientation that build upon the cultural value of reciprocity hold promise to improve T2D outcomes of older American Indian people.