bluuebunny/crossref_metadata_2025 huggingface dataset:
A Proposal for an MPPT Algorithm Based on the Fluctuations of the PV Output Power, Output Voltage, and Control Duty Cycle for Improving the Performance of PV Systems in Microgrid
Authors: Van Tan Nguyen , Nam Nguyen Binh , Hieu Nguyen Huu , Hung Le Kim , Duong Minh Quan , Lam Le Hong
Published: August 2020

In microgrids, distributed generators that cannot be dispatched, such as a photovoltaic system, need to control their output power at the maximum power point. The fluctuation of their output power should be minimized with the support of the maximum power point tracking algorithm under the variation of ambient conditions. In this paper, a new maximum power point tracking method based on the parameters of power deviation (ΔPPV), voltage difference (ΔVPV), and duty cycle change (ΔD) is proposed for photovoltaic systems. The presented algorithm achieves the following good results: (i) when the solar radiance is fixed, the output power is stable around the maximum power point; (ii) when the solar radiance is rapidly changing, the generated power is always in the vicinity of maximum power points; (iii) the effectiveness of energy conversion is comparable to that of intelligent algorithms. The proposed algorithm is presented and compared with traditional and intelligent maximum power point tracking algorithms on the simulation model by MATLAB/Simulink under different radiation scenarios to prove the effectiveness of the proposed method.
Carbon Dioxide Conversion with High-Performance Photocatalysis into Methanol on NiSe2/WSe2
Authors: Luo Zheng , Li Yinghan , Guo Fengbo , Zhang Kaizhi , Liu Kankan , Jia Wanli , Zhao Yuxia , Sun Yan
Published: August 2020

Climate change has been recognized as a threatening environmental problem around the world. CO2 is considered to be the main component of greenhouse gas. By using solar energy (light energy) as the energy source, photocatalytic conversion is one of the most effective technologies to reveal the clean utilization of CO2. Herein, using sodium tungstate, nickel nitrate, and selenium powder as the main raw materials, the high absorption and utilization of WSe2 for light energy and the high intrinsic conductivity of NiSe2 were combined by a hydrothermal method to prepare NiSe2/WSe2 and hydrazine hydrate as the reductant. Then, high-performance NiSe2/WSe2 photocatalytic material was prepared. The characterization results of XRD, XPS, SEM, specific surface area, and UV-visible spectroscopy show that the main diffraction peak of synthesized NiSe2/WSe2 is sharp, which basically coincides with the standard card. After doping NiSe2, the morphology of WSe2 was changed from a flake shape to smaller and more trivial crystal flakes, which demonstrates richer exposed edges and more active sites; the specific surface area increased from 3.01 m2 g−1 to 8.52 m2 g−1, and the band gap becomes wider, increasing from 1.66 eV to 1.68 eV. The results of a photocatalytic experiment show that when the prepared NiSe2/WSe2 catalyst is used to conduct photocatalytic reduction of CO2, the yield of CH3OH is significantly increased. After reaction for 10 h, the maximum yield could reach 3.80 mmol g−1, which presents great photocatalytic activity.
Energetic, Economic and Environmental (3E) Assessment and Design of Solar-Powered HVAC Systems in Pakistan
Authors: Mehmood Sajid , Maximov Serguey A. , Chalmers Hannah , Friedrich Daniel
Published: August 2020

Rapid urbanization, global warming and enhanced quality of life have significantly increased the demand of indoor thermal comfort and air conditioning systems are not a luxury anymore, but a necessity. In order to fulfil this need, it is imperative to develop affordable and environmentally friendly cooling solutions for buildings. In this work, the 3E performance (energetic, economic and environmental) of electrically driven water-cooled vapour compression systems and thermally (solar) driven vapour absorption cooling systems are evaluated and the parameters affecting the performance of solar-driven vapour absorption systems are investigated. The energy simulation software TRNSYS is used to simulate the performance of both systems in order to fulfil the cooling needs of an industrial manufacturing building for the typical climate conditions for Lahore, Pakistan. Primary energy saving, initial investment, operational cost, and carbon footprint indices are used to analyse the performance of both systems. In addition, a parametric code is written in Python and linked with TRNSYS to perform a parametric study to investigate the effects of various parameters such as solar field size, storage tank volume, optimum annual and monthly collector angles, and flow rate in the solar field on the solar-driven vapour absorption chiller performance. The results reveal that around 5% more energy can be absorbed per collector surface area by changing the solar tilt angle on a monthly basis compared to one fixed angle. The analysis shows that electrically driven vapour compression-based cooling systems have much higher running cost and are potentially hazardous for the environment but have lower capital costs. On the other hand, solar thermal systems have lower running costs and emissions but require further reductions in the capital costs or government subsidies to make them viable.
Effect of Heat Source Placement on Natural Convection from Cylindrical Surfaces
Authors: Kapjor Andrej , Durcansky Peter , Vantuch Martin
Published: August 2020

Placement of heat source can play a significant role in final heat output, or heat source effectivity. Because of this, there is a need to analyze thermal fields of the heat exchange system by natural convection, where the description by criterion equations is desired, as the net heat output from tubes can be quantified. Based on known theoretical models, numerical methods were adapted to calculate the heat output with natural air flow around tubes, where mathematical models were used to describe the heat transfer more precisely. After validation of heat transfer coefficients, the effect of wall and heat source placement was studied, and the Coanda effect was also observed. The heat source placement also has an effect at the boundary layer, which can change and therefore affect the overall heat transfer process. The optimal wall-to-cylinder distance for an array of horizontal cylinders near a wall was also expressed as a function of the Rayleigh number and number of cylinders in the array.
The Dynamic Performance Analysis of a Low-Floor Tram Hydraulic Anti-Kink System Based on Multidisciplinary Collaboration
Authors: Liao Xiaokang , Chen Zili , Jia Yiping , Lin Jianhui
Published: August 2020

According to the basic principle of the hydraulic anti-kink system and flow continuity equation, this paper takes the low-floor tram as the research object and the four vehicles as the research carrier. Based on the correlation parameters between the vehicle subsystem and the hydraulic subsystem, a co-simulation platform of a low-floor tram with hydraulic an anti-kink system is built. The co-simulation results show that the anti-kink system can well maintain the relative yaw angle consistency between the vehicle body and bogie. The anti-kink system restrains the maximum yaw angle and excessive lateral displacement of the vehicle body effectively. The consistency between the experiment results and the simulation results shows the accuracy of the model. The co-simulation model of the low-floor tram with hydraulic anti-kink system can be used to research the dynamic performance when it passes through curve line.
Modeling the Influence of Knots on Douglas-Fir Veneer Fiber Orientation
Authors: Frayssinhes Rémy , Girardon Stéphane , Denaud Louis , Collet Robert
Published: August 2020

This study presents a method for predicting the local fiber orientation of veneers made from peeled Douglas-fir logs based on the knowledge of the tree branch characteristics (location, radius, insertion angle, azimuth angle, and living branch ratio). This model is based on the Rankine oval theory approach and focuses on the local deviation of the fiber orientation in the vicinity of knots. The local fiber orientation was measured online during the peeling process with an in-house-developed scanner based on the tracheid effect. Two logs from the same tree were peeled, and their ribbons were scanned. The knot locations and fiber orientation were deduced from the scanner data. The first objective was to compare the fiber orientation model with measurements to enhance and validate the model for French Douglas-fir. The second objective was to link data measurable on logs to veneer quality.
Stabilization and Incipient Carbonization of Electrospun Polyacrylonitrile Nanofibers Fixated on Aluminum Substrates
Authors: Storck Jan Lukas , Grothe Timo , Tuvshinbayar Khorolsuren , Diestelhorst Elise , Wehlage Daria , Brockhagen Bennet , Wortmann Martin , Frese Natalie , Ehrmann Andrea
Published: August 2020

Polyacrylonitrile (PAN) nanofibers, prepared by electrospinning, are often used as a precursor for carbon nanofibers. The thermal carbonization process necessitates a preceding oxidative stabilization, which is usually performed thermally, i.e., by carefully heating the electrospun nanofibers in an oven. One of the typical problems occurring during this process is a strong deformation of the fiber morphologies—the fibers become thicker and shorter, and show partly undesired conglutinations. This problem can be solved by stretching the nanofiber mat during thermal treatment, which, on the other hand, can lead to breakage of the nanofiber mat. In a previous study, we have shown that the electrospinning of PAN on aluminum foils and the subsequent stabilization of this substrate is a simple method for retaining the fiber morphology without breaking the nanofiber mat. Here, we report on the impact of different aluminum foils on the physical and chemical properties of stabilized PAN nanofibers mats, and on the following incipient carbonization process at a temperature of max. 600 °C, i.e., below the melting temperature of aluminum.
Living the Sweet Life: How Liquorilactobacillus hordei TMW 1.1822 Changes Its Behavior in the Presence of Sucrose in Comparison to Glucose
Authors: Bechtner Julia , Ludwig Christina , Kiening Michael , Jakob Frank , Vogel Rudi F.
Published: August 2020

Liquorilactobacillus (L.) hordei (formerly Lactobacillus hordei) is one of the dominating lactic acid bacteria within the water kefir consortium, being highly adapted to survive in this environment, while producing high molecular weight dextrans from sucrose. In this work, we extensively studied the physiological response of L. hordei TMW 1.1822 to sucrose compared to glucose, applying label-free, quantitative proteomics of cell lysates and exoproteomes. This revealed the differential expression of 53 proteins within cellular proteomes, mostly associated with carbohydrate uptake and metabolism. Supported by growth experiments, this suggests that L. hordei TMW 1.1822 favors fructose over other sugars. The dextransucrase was expressed irrespectively of the present carbon source, while it was significantly more released in the presence of sucrose (log2FC = 3.09), being among the most abundant proteins within exoproteomes of sucrose-treated cells. Still, L. hordei TMW 1.1822 expressed other sucrose active enzymes, predictively competing with the dextransucrase reaction. While osmolysis appeared to be unlikely, sucrose led to increased release of a multitude of cytoplasmic proteins, suggesting that biofilm formation in L. hordei is not only composed of a polysaccharide matrix but is also of proteinaceous nature. Therefore, our study highlights the intrinsic adaptation of water kefir-borne L. hordei to sucrose-rich habitats and provides fundamental knowledge for its use as a starter culture in plant-based food fermentations with in situ dextran formation.
Is There Scope for a Novel Mycelium Category of Proteins alongside Animals and Plants?
Authors: Derbyshire Emma J.
Published: August 2020

In the 21st century, we face a troubling trilemma of expanding populations, planetary and public wellbeing. Given this, shifts from animal to plant food protein are gaining momentum and are an important part of reducing carbon emissions and consumptive water use. However, as this fast-pace of change sets in and begins to firmly embed itself within food-based dietary guidelines (FBDG) and food policies we must raise an important question—is now an opportunistic time to include other novel, nutritious and sustainable proteins within FBGD? The current paper describes how food proteins are typically categorised within FBDG and discusses how these could further evolve. Presently, food proteins tend to fall under the umbrella of being ‘animal-derived’ or ‘plant-based’ whilst other valuable proteins i.e., fungal-derived appear to be comparatively overlooked. A PubMed search of systematic reviews and meta-analytical studies published over the last 5 years shows an established body of evidence for animal-derived proteins (although some findings were less favourable), plant-based proteins and an expanding body of science for mycelium/fungal-derived proteins. Given this, along with elevated demands for alternative proteins there appears to be scope to introduce a ‘third’ protein category when compiling FBDG. This could fall under the potential heading of ‘fungal’ protein, with scope to include mycelium such as mycoprotein within this, for which the evidence-base is accruing.
Urban Consumer Trust and Food Certifications in China
Authors: Moruzzo Roberta , Riccioli Francesco , Boncinelli Fabio , Zhang Zhaozhong , Zhao Jinjin , Tang Yaojia , Tinacci Lara , Massai Tommaso , Guidi Alessandra
Published: August 2020

China has experienced frequent food safety incidents that have undermined consumer trust in the food supply chain. To overcome this problem, China requalified the legislative framework and adopted a comprehensive food certification system over the years. Here, we investigated the influences of food traceability and Chinese certifications (QS/SC—food quality safety market access/production system, hazard-free, green, and organic) on Chinese consumer trust of food safety for different types of products: fish, meat, milk, eggs, and rice. Data were collected through face-to-face surveys conducted in rural and urban Chinese areas. With a sample of 757 questionnaires, we ran a logit model. The results show consumers’ uncertainty and skepticism of certifications guaranteeing food safety attributes, especially for animal-based products. We found that price is used as a cue of safety by Chinese consumers. Individuals with higher education seem less influenced by certifications and other cues included in the analysis. The findings demonstrate that Chinese policy makers should implement new strategies to enhance consumer food safety trust, and design policies by considering different categories (e.g., vegetables, meat, fish, etc.) of food.
Long-Term Trend of Liver Cancer Mortality in Serbia, 1991–2015: An Age-Period-Cohort and Joinpoint Regression Analysis
Authors: Ilic Irena , Sipetic Grujicic Sandra , Grujicic Jovan , Radovanovic Djordje , Zivanovic Macuzic Ivana , Kocic Sanja , Ilic Milena
Published: August 2020

Background and Objectives: Trends of liver cancer mortality vary widely around the world. The purpose of this study was to assess the trend of liver cancer mortality in Serbia. Material and Methods: Descriptive epidemiological study design was used in this research. The age-standardized rates (ASRs, per 100,000) were calculated using the direct method, according to the World standard population. Temporal trends were assessed using the average annual percent change (AAPC) with 95% confidence interval (95% CI), according to joinpoint regression. An age-period-cohort analysis was used to evaluate the underlying factors for liver cancer mortality trends. Results: In Serbia from 1991 to 2015, over 11,000 men and nearly 8000 women died from liver cancer. The trend in liver cancer mortality significantly decreased both in men (AAPC = −1.3%; 95% CI = −1.7 to −0.9) and women (AAPC = −1.5%; 95% CI = −1.9 to −1.1). For liver cancer mortality, statistically significant cohort and period effects were observed in both genders. Conclusions: The downward trends in liver cancer mortality in Serbia are recorded during the past decades.
Lung Function and Respiratory Health of Populations Living Close to Quarry Sites in Palestine: A Cross-Sectional Study
Authors: Nemer Maysaa , Giacaman Rita , Husseini Abdullatif
Published: August 2020

Environmental exposure to dust from quarrying activities could pose health dangers to the population living nearby. This study aimed to investigate the health effects of dust exposure on people living close to quarry sites and compared them with those who live far from the quarry sites. A cross-sectional comparative study was conducted among 79 exposed participants, who lived less than 500 m away from the quarry sites, and 79 control participants who lived more than 500 m away. All participants answered a questionnaire on dust exposure at home and health effects, as well as performed a lung function test in which both reported and measured health effects were investigated. People who live in close proximity to the quarry sites reported exposure to dust at home (98%), land destruction (85%), plant leaves covered with dust (97%), and an inability to grow crops (92%). The exposed group reported significantly higher eye and nasal allergy (22% vs. 3%), eye soreness (18% vs. 1%), and dryness (17% vs. 3%), chest tightness (9% vs. 1%), and chronic cough (11% vs. 0%) compared to the control group. Lung function parameters were significantly lower among the exposed group compared to the control group; mean forced vital capacity (FVC) was 3.35 L vs. 3.71 L (p = 0.001), mean forced expiratory volume in the first second (FEV1) was 2.78 L vs. 3.17 L (p = 0.001). Higher levels of airway restriction were found among the exposed group. Among the exposed group, lung function parameters worsened with the increasing closeness of home to the quarry site. This study demonstrates the negative health effects of environmental dust exposure among two communities living near quarry sites in Palestine. The results highlight the importance of developing and strictly enforcing rules and regulations in Palestine to protect population health.
Physical Activity Counseling for Adults with Hypertension: A Randomized Controlled Pilot Trial
Authors: Sousa Junior Altieres E. , Macêdo Geovani A. D. , Schwade Daniel , Sócrates Júlio , Alves José W. , Farias-Junior Luiz F. , Freire Yuri A. , Lemos Telma M. A. M. , Browne Rodrigo A. V. , Costa Eduardo C.
Published: August 2020

The effect of physical activity counseling (PAC) in hypertensive adults is unclear. This study investigated the effect of PAC on blood pressure (BP), physical activity level, sitting time, metabolic profile, and body composition in hypertensive adults. Twenty-two hypertensive adults (48.8 ± 7.3 years) participated in this pilot trial. The 12-week PAC was based on the 5 A’s model considering the FITT principle (Frequency, Intensity, Time, and Type) of physical activity. The control group received instructions about FITT in one face-to-face meeting at baseline. Pedometer-measured physical activity, sitting time, resting and ambulatory BP, metabolic profile (cholesterol, triglycerides, fasting glucose), and body composition (fat mass, abdominal fat, fat free mass) were assessed. The PAC group showed higher steps per day (5839 ± 992 vs. 5028 ± 902; p = 0.044) and a trend for lower sitting time (5.6 ± 1.3 vs. 8.0 ± 4.0 h/day; p = 0.059) than the control group. No changes were observed in BP, metabolic profile, and body composition (p > 0.05). In conclusion, 12 weeks of a PAC program based on the 5 A’s model resulted in a modest increase of ~800 steps per day and a trend to decrease ~2 h/day in sitting time, but there were no associated reduction in BP and improvements in metabolic and body composition.
Social Network Communications in Chilean Older Adults
Authors: Rondán-Cataluña Francisco Javier , Ramírez-Correa Patricio E. , Arenas-Gaitán Jorge , Ramírez-Santana Muriel , Grandón Elizabeth E. , Alfaro-Pérez Jorge
Published: August 2020

The growth of older adults in new regions poses challenges for public health. We know that these seniors live increasingly alone, and this impairs their health and general wellbeing. Studies suggest that social networking sites (SNS) can reduce isolation, improve social participation, and increase autonomy. However, there is a lack of knowledge about the characteristics of older adult users of SNS in these new territories. Without this information, it is not possible to improve the adoption of SNS in this population. Based on decision trees, this study analyzes how the elderly users of various SNS in Chile are like. For this purpose, a segmentation of the different groups of elderly users of social networks was constructed, and the most discriminating variables concerning the use of these applications were classified. The results highlight the existence of considerable differences between the various social networks analyzed in their use and characterization. Educational level is the most discriminating variable, and gender influences the types of SNS use. In general, it is observed that the higher the educational level, the more the different social networking sites are used.
Beneficial Effects of Interactive Physical-Cognitive Game-Based Training on Fall Risk and Cognitive Performance of Older Adults
Authors: Phirom Kochaphan , Kamnardsiri Teerawat , Sungkarat Somporn
Published: August 2020

Physical and cognitive declines are significant risk factors for falls. Promising evidence suggests that combined physical-cognitive training would be an effective fall risk reduction and cognitive improvement intervention. However, a limited number of studies have been conducted and findings have been inconclusive. This study investigated the effects of interactive physical-cognitive game-based training on the fall risk and cognitive performance of older adults. Forty participants were randomly allocated to the intervention (n = 20) and control (n = 20) groups. Participants in the intervention group performed a 1 h session, 3 times a week for 12 weeks of the interactive physical-cognitive game-based training program. Fall risk (Physiological Profile Assessment, PPA; and Timed Up and Go, TUG) and cognitive outcome (Montreal Cognitive Assessment, MoCA) were assessed at pre- and post-intervention. Thirty-nine participants (mean age = 69.81 ± 3.78 years) completed the study (97.5%). At the end of the trial, participants in the intervention group demonstrated significant improvement in the PPA fall risk score (p = 0.015), postural sway (p = 0.005), MoCA score (p = 0.001), and TUG-dual task (p = 0.045) compared to controls. In conclusion, the interactive physical-cognitive, game-based training was effective in reducing physiological fall risk and improving cognitive function in community-dwelling older adults.
The Prototypes of Tobacco Users Scale (POTUS) for Cigarette Smoking and E-Cigarette Use: Development and Validation
Authors: Butler Eboneé N. , Hall Marissa G. , Chen May S. , Pepper Jessica K. , Blanton Hart , Brewer Noel T.
Published: August 2020

Endorsing prototypes of cigarette smokers predicts cigarette smoking, but less is known about prototypes of users of other tobacco products. Our study sought to establish the reliability and validity of a measure of prototypes of smokers and e-cigarette users. Participants were from a national survey of smokers and non-smokers (n = 1414), a randomized clinical trial (RCT) of adult smokers (n = 2149), and adolescent children of adults in the trial (n = 112). The Prototypes of Tobacco Users Scale (POTUS) has four positive adjectives (cool, sexy, smart, and healthy) and four negative adjectives (disgusting, unattractive, immature, and inconsiderate) describing cigarette smokers and e-cigarette users. Confirmatory factor analyses identified a two-factor solution. The POTUS demonstrated strong internal consistency reliability in all three samples (median α = 0.85) and good test–retest reliability among adults in the RCT (median r = 0.61, 1–4 weeks follow-up). In the RCT, smokers more often agreed with negative prototypes for smokers than for e-cigarette users (mean = 2.03 vs. 1.67, p < 0.05); negative prototypes at baseline were also associated with more forgoing of cigarettes and making a quit attempt at the end of the trial (Week 4 follow-up). The POTUS may be useful to public health researchers seeking to design interventions that reduce tobacco initiation or cessation through the manipulation of tobacco user prototypes.
Improving Aviation Safety through Modeling Accident Risk Assessment of Runway
Authors: Yousefi Yaser , Karballaeezadeh Nader , Moazami Dariush , Sanaei Zahed Amirhossein , Mohammadzadeh S. Danial , Mosavi Amir
Published: August 2020

The exponential increase in aviation activity and air traffic in recent decades has raised several public health issues. One of the critical public health concerns is runway safety and the increasing demand for airports without accidents. In addition to threatening human lives, runway accidents are often associated with severe environmental and pollution consequences. In this study, a three-step approach is used for runway risk assessment considering probability, location, and consequences of accidents through advanced statistical methods. This study proposes novel models for the implementation of these three steps in Iran. Data on runway excursion accidents were collected from several countries with similar air accident rates. The proposed models empower engineers to advance an accurate assessment of the accident probability and safety assessment of airports. For in-service airports, it is possible to assess existing runways to remove obstacles close to runways if necessary. Also, the proposed models can be used for preliminary evaluations of developing existing airports and the construction of new runways.
Exposure to ZnO/TiO2 Nanoparticles Affects Health Outcomes in Cosmetics Salesclerks
Authors: Lee Ching-Chang , Lin Yi-Hsin , Hou Wen-Che , Li Meng-Han , Chang Jung-Wei
Published: August 2020

Concerns about the effects of nanoparticles (NPs) on human health are being raised by researchers because the risks of nanocosmetics like sunscreen are unknown. We explored the association between urinary oxidative stress markers and exposure of cosmetics salesclerks to 20 cosmetics that might contain titanium dioxide (TiO2)/zinc oxide (ZnO) NPs. We then recruited 40 cosmetics salesclerks and 24 clothing salesclerks and categorized them based on their exposure to ZnO and TiO2 NPs. Nineteen and 15 samples met the EU definition for TiO2 and ZnO nanomaterials, respectively. Participants with a higher co-exposure index of ZnO and TiO2 NPs had a significantly higher base level of urinary 8-hydroxy-2′-deoxyguanosin (8-OHdG) concentrations than the lower co-exposure group (5.82 vs. 2.85 ng/mL, p < 0.001). After potential confounding factors had been adjusted for, the TiO2 and ZnO NP co-exposure index was significantly positively associated with the urinary 8-OHdG base concentration (β = 0.308, 95% CI = 0.106 to 0.510) and the creatinine-adjusted concentration (β = 0.486, 95% CI = 0.017 to 0.954). Current evidence suggests that the likelihood of harm from using sunscreens containing nanoparticles might result in higher urinary 8-OHdG. However, our limited number and types of sample cosmetics might underestimate the risk.
Weather Conditions and Outdoor Fall Injuries in Northwestern Russia
Authors: Unguryanu Tatiana N. , Grjibovski Andrej M. , Trovik Tordis A. , Ytterstad Børge , Kudryavtsev Alexander V.
Published: August 2020

This study aimed to investigate associations between the weather conditions and the frequency of medically-treated, non-fatal accidental outdoor fall injuries (AOFIs) in a provincial region of Northwestern Russia. Data on all non-fatal AOFIs that occurred from January 2015 through June 2018 (N = 1125) were extracted from the population-based Shenkursk Injury Registry (SHIR). Associations between the weather conditions and AOFIs were investigated separately for the cold (15 October–14 April) and the warm (15 April–14 October) seasons. Negative binomial regression was used to investigate daily numbers of AOFIs in the cold season, while zero-inflated Poisson regression was used for the warm season. The mean daily number of AOFIs was 1.7 times higher in the cold season compared to the warm season (1.10 vs. 0.65, respectively). The most typical accident mechanism in the cold season was slipping (83%), whereas stepping wrong or stumbling over something was most common (49%) in the warm season. The highest mean daily incidence of AOFIs in the cold season (20.2 per 100,000 population) was observed on days when the ground surface was covered by compact or wet snow, air temperature ranged from −7.0 °C to −0.7 °C, and the amount of precipitation was above 0.4 mm. In the warm season, the highest mean daily incidence (7.0 per 100,000 population) was observed when the air temperature and atmospheric pressure were between 9.0 °C and 15.1 °C and 1003.6 to 1010.9 hPa, respectively. Along with local weather forecasts, broadcasting warnings about the increased risks of outdoor falls may serve as an effective AOFI prevention tool.
A Systematic Review of the Guidelines and Delphi Study for the Multifactorial Fall Risk Assessment of Community-Dwelling Elderly
Authors: Kim Jieun , Lee Worlsook , Lee Seon Heui
Published: August 2020

As falls are among the most common causes of injury for the elderly, the prevention and early intervention are necessary. Fall assessment tools that include a variety of factors are recommended for preventing falls, but there is a lack of such tools. This study developed a multifactorial fall risk assessment tool based on current guidelines and validated it from the perspective of professionals. We followed the Meta-Analysis of Observational Studies in Epidemiology’s guidelines in this systematic review. We used eight international and five Korean databases to search for appropriate guidelines. Based on the review results, we conducted the Delphi survey in three rounds; one open round and two scoring rounds. About nine experts in five professional areas participated in the Delphi study. We included nine guidelines. After conducting the Delphi study, the final version of the “Multifactorial Fall Risk Assessment tool for Community-Dwelling Older People” (MFA-C) has 36 items in six factors; general characteristics, behavior factors, disease history, medication history, physical function, and environmental factors. The validity of the MFA-C tool was largely supported by various academic fields. It is expected to be beneficial to the elderly in the community when it comes to tailored interventions to prevent falls.
Perceived and Real Aquatic Competence in Children from 6 to 10 Years Old
Authors: Costa Aldo M. , Frias Alexandra , Ferreira Sandra S. , Costa Mario J. , Silva António J. , Garrido Nuno D.
Published: August 2020

This study aimed to analyze the relationship between perceived aquatic competence (PAC) and real aquatic competence (RAC) in 6 to 10 year old children in skills identified as relevant for surviving an aquatic accident. The study sample consisted of 105 children (8.2 + 1.3 years old). Two age groups were examined separately [G1, 6 to 7 years (n = 53); G2, 8 to 10 years (n = 52)]. Children’s aquatic competence was evaluated twice for skills linked to the risk of drowning: Firstly, using a common swimsuit (simple condition) and secondly wearing a t-shirt (complex condition). The PAC was assessed by questionnaire interview. Pearson correlation coefficients, pairwise, and independent t-test comparisons were performed with a significance level of 5%. Similar levels of PAC were found among both age groups for all measured skills, excepted for breath control during swimming (p < 0.05). However, PAC differs significantly (p < 0.001) from RAC (in simple and complex conditions) only in G1. Correlations between PAC and RAC were modest for all measured skills in both age-groups. Significant differences were found between RAC in simple and complex conditions in both groups (p < 0.01). Age contributes to a higher perceived aquatic competence in skills related to the risk of drowning.
Using the Multi-Theory Model (MTM) of Health Behavior Change to Explain Intentional Outdoor Nature Contact Behavior among College Students
Authors: Sharma Manoj , Largo-Wight Erin , Kanekar Amar , Kusumoto Hana , Hooper Stephanie , Nahar Vinayak K.
Published: August 2020

Nature contact is an emerging health behavior and is defined as the interaction between human beings and animals, plants, natural scenic views, or outdoor activities. Studies have shown that exposure to the outdoors (as a means of contact with nature) reduces perceived stress and promotes health and wellbeing among varying populations in many settings. To date, however, there are few studies exploring the impact of nature contact among college students, especially in the United States. In addition, the determinants of nature contact behavior have not adequately been explored using behavioral theories. The purpose of this study was to use the multi-theory model (MTM) of health behavior change, a contemporary fourth-generation behavioral theory in explaining intentional outdoor nature contact behavior among college students. Using a cross-sectional design, 401 students completed the validated survey based on MTM. Of these, 281 met the inclusion criteria. The mean score for perceived stress based on the Perceived Stress Scale (PSS-10) in the sample was 21.60 (7.08) units, with a possible minimum and maximum scores ranging from 0 to 40 units. Constructs of behavioral confidence (standardized coefficient = 0.591, p < 0.001) and changes in the physical environment (standardized coefficient = 0.271, p < 0.001) from MTM accounted for 57.5% of the variance in the initiation for intentional outdoor nature contact behavior. All the three constructs of MTM—namely, emotional transformation (standardized coefficient = 0.173, p = 0.021), practice for change (standardized coefficient = 0.317, p < 0.001), and changes in the social environment (standardized coefficient = 0.204, p = 0.002)—were statistically significant and contributed substantively toward the variance (31.0%) in sustenance. MTM provides a useful and pragmatic framework for designing interventions to promote intentional nature contact behavior among college students.
The Influence of Cross-Section Thickness on Diameter at Breast Height Estimation from Point Cloud
Authors: Koreň Milan , Hunčaga Milan , Chudá Juliana , Mokroš Martin , Surový Peter
Published: August 2020

Circle-fitting methods are commonly used to estimate diameter at breast height (DBH) of trees from horizontal cross-section of point clouds. In this paper, we addressed the problem of cross-section thickness optimization regarding DBH estimation bias and accuracy. DBH of 121 European beeches (Fagus sylvatica L.) and 43 Sessile oaks (Quercus petraea (Matt.) Liebl.) was estimated from cross-sections with thicknesses ranging from 1 to 100 cm. The impact of cross-section thickness on the bias, standard error, and accuracy of DBH estimation was statistically significant. However, the biases, standard errors, and accuracies of DBH estimation were not significantly different among 1–10-cm cross-sections, except for oak DBH estimation accuracy from an 8-cm cross-section. DBH estimations from 10–100-cm cross-sections were considerably different. These results provide insight to the influence of cross-section thickness on DBH estimation by circle-fitting methods, which is beneficial for point cloud data acquisition planning and processing. The optimal setting of cross-section thickness facilitates point cloud processing and DBH estimation by circle-fitting algorithms.
Research of Automatic Generation for Engineering Geological Survey Reports Based on a Four-Dimensional Dynamic Template
Authors: Lei Yujiao , Deng Jiqiu , Lin Jian , Dick Jeffrey M. , Lessani Mohammad Naser , Liu Chaoyue
Published: August 2020

Errors and inefficiency may be caused by manual processing of complex templates for the preparation and management of engineering survey reports. To address this problem, this paper analyzes the multidimensional variable features of professional field documents and proposes a generation model of standardized reports based on a four-dimensional dynamic template. This approach splits the standardized report into multiple parts to construct a hierarchical tree that represents the report structure according to the report rules, then stores the tree in a graph database, and finally generates the desired report dynamically by retrieving the relational tree for the template and obtaining the relevant data. The model has been applied to the engineering geological survey report system and is shown to improve the working efficiency and data accuracy of the report preparation. Results indicate that the model is feasible and effective.
The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo
Authors: Siebuhr Anne Sofie , Werkmann Daniela , Bay-Jensen Anne-C. , Thudium Christian S. , Karsdal Morten Asser , Serruys Benedikte , Ladel Christoph , Michaelis Martin , Lindemann Sven
Published: August 2020

Osteoarthritis (OA) is associated with cartilage breakdown, brought about by ADAMTS-5 mediated aggrecan degradation followed by MMP-derived aggrecan and type II collagen degradation. We investigated a novel anti-ADAMTS-5 inhibiting Nanobody® (M6495) on cartilage turnover ex vivo. Bovine cartilage (BEX, n = 4), human osteoarthritic - (HEX, n = 8) and healthy—cartilage (hHEX, n = 1) explants and bovine synovium and cartilage were cultured up to 21 days in medium alone (w/o), with pro-inflammatory cytokines (oncostatin M (10 ng/mL) + TNFα (20 ng/mL) (O + T), IL-1α (10 ng/mL) or oncostatin M (50 ng/mL) + IL-1β (10 ng/mL)) with or without M6495 (1000−0.46 nM). Cartilage turnover was assessed in conditioned medium by GAG (glycosaminoglycan) and biomarkers of ADAMTS-5 driven aggrecan degradation (huARGS and exAGNxI) and type II collagen degradation (C2M) and formation (PRO-C2). HuARGS, exAGNxI and GAG peaked within the first culture week in pro-inflammatory stimulated explants. C2M peaked from day 14 by O + T and day 21 in co-culture experiments. M6495 dose dependently decreased huARGS, exAGNxI and GAG after pro-inflammatory stimulation. In HEX C2M was dose-dependently reduced by M6495. M6495 showed no effect on PRO-C2. M6495 showed cartilage protective effects by dose-dependently inhibiting ADAMTS-5 mediated cartilage degradation and inhibiting overall cartilage deterioration in ex vivo cartilage cultures.
Characterization of the Role of SPL9 in Drought Stress Tolerance in Medicago sativa
Authors: Hanly Alexandria , Karagiannis Jim , Lu Qing Shi Mimmie , Tian Lining , Hannoufa Abdelali
Published: August 2020

Extreme environmental conditions, such as drought, are expected to increase in frequency and severity due to climate change, leading to substantial deficiencies in crop yield and quality. Medicago sativa (alfalfa) is an important crop that is relied upon as a staple source of forage in ruminant feed. Despite its economic importance, alfalfa production is constrained by abiotic stress, including drought. In this report, we investigate the role of Squamosa Promoter Binding Protein-Like 9 (SPL9), a target of miR156, in drought tolerance. Transgenic alfalfa plants with RNAi-silenced MsSPL9 (SPL9-RNAi) were compared to wild-type (WT) alfalfa for phenotypic changes and drought tolerance indicators. In SPL9-RNAi plants, both stem thickness and plant height were reduced in two- and six-month-old alfalfa, respectively; however, yield was unaffected. SPL9-RNAi plants showed less leaf senescence and had augmented relative water content under drought conditions, indicating that SPL9-RNAi plants had greater drought tolerance potential than WT plants. Interestingly, SPL9-RNAi plants accumulated more stress-alleviating anthocyanin compared to WT under both drought and well-watered control conditions, suggesting that MsSPL9 may contribute to drought tolerance in alfalfa, at least in part, by regulating anthocyanin biosynthesis. The results suggest that targeting MsSPL9 is a suitable means for improving alfalfa resilience towards drought conditions.
A Translational Paradigm to Study the Effects of Uncontrollable Stress in Humans
Authors: Meine Laura E. , Schüler Katja , Richter-Levin Gal , Scholz Vanessa , Wessa Michele
Published: August 2020

Theories on the aetiology of depression in humans are intimately linked to animal research on stressor controllability effects. However, explicit translations of established animal designs are lacking. In two consecutive studies, we developed a translational paradigm to study stressor controllability effects in humans. In the first study, we compared three groups of participants, one exposed to escapable stress, one yoked inescapable stress group, and a control group not exposed to stress. Although group differences indicated successful stress induction, the manipulation failed to differentiate groups according to controllability. In the second study, we employed an improved paradigm and contrasted only an escapable stress group to a yoked inescapable stress group. The final design successfully induced differential effects on self-reported perceived control, exhaustion, helplessness, and behavioural indices of adaptation to stress. The latter were examined in a new escape behaviour test which was modelled after the classic shuttle box animal paradigm. Contrary to the learned helplessness literature, exposure to uncontrollable stress led to more activity and exploration; however, these behaviours were ultimately not adaptive. We discuss the results and possible applications in light of the findings on learning and agency beliefs, inter-individual differences, and interventions aimed at improving resilience to stress-induced mental dysfunction.
G-Protein-Coupled Receptor (GPCR) Signaling in the Carotid Body: Roles in Hypoxia and Cardiovascular and Respiratory Disease
Authors: Aldossary Hayyaf S. , Alzahrani Abdulaziz A. , Nathanael Demitris , Alhuthail Eyas A. , Ray Clare J. , Batis Nikolaos , Kumar Prem , Coney Andrew M. , Holmes Andrew P.
Published: August 2020

The carotid body (CB) is an important organ located at the carotid bifurcation that constantly monitors the blood supplying the brain. During hypoxia, the CB immediately triggers an alarm in the form of nerve impulses sent to the brain. This activates protective reflexes including hyperventilation, tachycardia and vasoconstriction, to ensure blood and oxygen delivery to the brain and vital organs. However, in certain conditions, including obstructive sleep apnea, heart failure and essential/spontaneous hypertension, the CB becomes hyperactive, promoting neurogenic hypertension and arrhythmia. G-protein-coupled receptors (GPCRs) are very highly expressed in the CB and have key roles in mediating baseline CB activity and hypoxic sensitivity. Here, we provide a brief overview of the numerous GPCRs that are expressed in the CB, their mechanism of action and downstream effects. Furthermore, we will address how these GPCRs and signaling pathways may contribute to CB hyperactivity and cardiovascular and respiratory disease. GPCRs are a major target for drug discovery development. This information highlights specific GPCRs that could be targeted by novel or existing drugs to enable more personalized treatment of CB-mediated cardiovascular and respiratory disease.
Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment
Authors: Juan Alberto , Cimas Francisco J. , Bravo Iván , Pandiella Atanasio , Ocaña Alberto , Alonso-Moreno Carlos
Published: August 2020

Breast cancer is the most common invasive tumor in women and the second leading cause of cancer-related death. Nanomedicine raises high expectations for millions of patients as it can provide better, more efficient, and affordable healthcare, and it has the potential to develop novel therapeutics for the treatment of solid tumors. In this regard, targeted therapies can be encapsulated into nanocarriers, and these nanovehicles are guided to the tumors through conjugation with antibodies—the so-called antibody-conjugated nanoparticles (ACNPs). ACNPs can preserve the chemical structure of drugs, deliver them in a controlled manner, and reduce toxicity. As certain breast cancer subtypes and indications have limited therapeutic options, this field provides hope for the future treatment of patients with difficult to treat breast cancers. In this review, we discuss the application of ACNPs for the treatment of this disease. Given the fact that ACNPs have shown clinical activity in this clinical setting, special emphasis on the role of the nanovehicles and their translation to the clinic is placed on the revision.
Remodeling of Kv7.1 and Kv7.5 Expression in Vascular Tumors
Authors: Serrano-Novillo Clara , Oliveras Anna , Ferreres Joan Carles , Condom Enric , Felipe Antonio
Published: August 2020

Voltage-dependent potassium (Kv) channels contribute to the excitability of nerves and muscles. In addition, Kv participates in several cell functions, including cell cycle progression and proliferation. Kv channel remodeling has been associated with neoplastic cell growth and cancer. Kv7 channels are expressed in blood vessels, and they participate in the maintenance of vascular tone and are implicated in myocyte proliferation. Although evidence links Kv7 remodeling to different types of cancer, its expression in vascular tumors has never been studied. Endothelium-derived vascular neoplasms range from indolent lesions to highly aggressive and metastasizing cancers. Here, we show that Kv7.1 and Kv7.5 are evenly distributed in tunicas as well as the endothelium of healthy veins and arteries. The layered structure of vessels is lost in vascular tumors. By studying eight vascular tumors with different origins and characteristics, we found that Kv7.1 and Kv7.5 expression was changed in vascular cancers. While both channels were generally downregulated, Kv7.5 expression was clearly correlated with neoplastic malignancy. The vascular tumors did not contract; therefore, the role of Kv7 channels is probably related to proliferation rather than controlling vascular tone. Our results identify vascular Kv7 channels as targets for cancer detection and anticancer therapies.
Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity
Authors: Kwak Choong-Hwan , Jin Ling , Han Jung Ho , Han Chang Woo , Kim Eonmi , Cho MyoungLae , Chung Tae-Wook , Bae Sung-Jin , Jang Se Bok , Ha Ki-Tae
Published: August 2020

In cancer cells, aerobic glycolysis rather than oxidative phosphorylation (OxPhos) is generally preferred for the production of ATP. In many cancers, highly expressed pyruvate dehydrogenase kinase 1 (PDK1) reduces the activity of pyruvate dehydrogenase (PDH) by inducing the phosphorylation of its E1α subunit (PDHA1) and subsequently, shifts the energy metabolism from OxPhos to aerobic glycolysis. Thus, PDK1 has been regarded as a target for anticancer treatment. Here, we report that ilimaquinone (IQ), a sesquiterpene quinone isolated from the marine sponge Smenospongia cerebriformis, might be a novel PDK1 inhibitor. IQ decreased the cell viability of human and murine cancer cells, such as A549, DLD-1, RKO, and LLC cells. The phosphorylation of PDHA1, the substrate of PDK1, was reduced by IQ in the A549 cells. IQ decreased the levels of secretory lactate and increased oxygen consumption. The anticancer effect of IQ was markedly reduced in PDHA1-knockout cells. Computational simulation and biochemical assay revealed that IQ interfered with the ATP binding pocket of PDK1 without affecting the interaction of PDK1 and the E2 subunit of the PDH complex. In addition, similar to other pyruvate dehydrogenase kinase inhibitors, IQ induced the generation of mitochondrial reactive oxygen species (ROS) and depolarized the mitochondrial membrane potential in the A549 cells. The apoptotic cell death induced by IQ treatment was rescued in the presence of MitoTEMPO, a mitochondrial ROS inhibitor. In conclusion, we suggest that IQ might be a novel candidate for anticancer therapeutics that act via the inhibition of PDK1 activity.