bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Spectrum by J. Gold
Authors: Campbell Sandy
Published: August 2018

Gold, Jennifer. On the Spectrum. Second Story Press, 2017

This story is about Clara, a teenage girl who lives in a dysfunctional family. Her divorced parents live in the US and France with their new partners. Clara’s mother is an ageing ballerina, who has an eating disorder that has led to osteoporosis. She has raised Clara to have an unhealthy obsession with food and food restrictions. There is a particularly pathetic description of Clara feeling too guilty to secretly keep even one of her Halloween candies, which her mother has trained her to throw down the garbage chute, after she has gone door-to-door in her costume.     

Clara moves to Paris, France for the summer to be with her father, stepmother and ten-year-old stepbrother, Alistair, who is on the autism/Asperger’s spectrum. Gold paints a picture of a child who is “neurotypically different,” exhibiting lack of interpersonal skills, taking things literally, having no verbal filter and being easily overwhelmed by noise, smells, small spaces, heights and crowds. Finally, to round out the summer cast, there is Michael, a black ethnic Angolan baker, who becomes Clara’s boyfriend.

Usually being “on the spectrum” refers to autism/Asperger’s, but Gold is trying to point out that eating disorders also exist on a sort of spectrum. She uses Alistair’s bluntness as a socially acceptable method of commenting on facets of eating disorders. She arranges to have the most uncomfortable comments and pointed questions come from Alistair’s mouth. While the depiction of autism/Asperger’s is accurate and even Clara’s seemingly intuitive knowledge of how to manage Alistair is believable, Michael’s “helping” Clara with her eating disorder is less so. Through the arc of the story, Clara comes to acknowledge that she has an eating disorder. However, that this should result simply from the encouragement, and sometimes annoyance and disappointment of a new boyfriend is unrealistic. Were it that simple, eating disorders would have been cured long ago. However, this novel does give readers an opportunity to explore two mental disorders in a sympathetic way.

Recommended for public libraries and junior high and high school libraries.

Recommended:  3 out of 4 starsReviewer:  Sandy Campbell

Sandy is a Health Sciences Librarian at the University of Alberta, who has written hundreds of book reviews across many disciplines.  Sandy thinks that sharing books with children is one of the greatest gifts anyone can give.
ENTREVISTA: PROFESSOR JÚLIO CÉSAR PAISANI
Authors: Barros Antônio Carlos de
Published: August 2018

Em janeiro de 2017, a Clio Arqueológica entrevistou o Professor Júlio César Paisani. Bolsista de Produtividade em Pesquisa do CNPq, o Professor possui graduação em Geografia pela Universidade Federal do Paraná (1995) e mestrado (1998) e doutorado (2004) em Geografia pela Universidade Federal de Santa Catarina. É professor associado da Universidade Estadual do Oeste do Paraná (Unioeste) e coordena o Laboratório de Microscopia Ótica da Unioeste (Micromorfologia). Colabora com as pesquisas do LEVOC – Laboratório Interdisciplinar de Pesquisas em Evolução, Cultura e Meio Ambiente do Museu de Arqueologia e Etnologia (MAE)/USP. É consultor científico do CNPq, da Fundação Araucária de Apoio ao Desenvolvimento Científico e Tecnológico do Estado Paraná) e das revistas científicas: Quaternary International (Elsevier), Pesquisas em Geociências (UFRGS), Revista Brasileira de Geomorfologia (UGB), Geologia USP. Série Científica, GEOSUL (UFSC), Ciência e Agrotecnologia (UFLA), Terr@ Plural (UEPG), Ambiência (UNICENTRO) e Bol. de Geografia (UEM).
FUNDAMENTOS DA PALEOPARASITOLOGIA, Luiz Fernando Ferreira; Karl Jan Reinhard; Adauto Araújo (organizadores)
Authors: Martin Gabriela
Published: August 2018

A Paleoparasitologia tem-se desenvolvido amplamente no Brasil nas últimas décadas, e esse avanço deve-se em grande parte aos trabalhos dos pesquisadores da Escola Nacional de Saúde Pública da Fundação Oswaldo Cruz, sediada no Rio de Janeiro.
EFEITOS DA EROSÃO EM SÍTIOS ARQUEOLÓGICOS NO ESTADO DE GOIÁS: Casos de Serranópolis e Palestina de Goiás
Authors: Rubin Julio Cezar Rubin de , Lorenzo Francisco José Catalano de , Silva Rosiclér Theodoro da , Correa Daniel Dos Santos
Published: August 2018

Os sítios arqueológicos dos municípios de Serranópolis e Palestina de Goiás, no sudoeste do Estado de Goiás, estão sendo impactados por processos naturais e pela ação antrópica. O diagnóstico preliminar dos sítios GO-JA-13 e GO-CP-16 apresenta como causa principal a associação entre processos erosivos, desmatamento e pecuária. As medidas mitigadoras sugeridas incluem o isolamento das áreas de contribuição e a estabilização dos processos erosivos, por meio da captação das águas de escoamento superficial e subsuperficial e da contenção da ação erosiva de cursos d’água, na base dos taludes e nas ravinas, além de monitoramentos sistemáticos. EROSIVE EFFECTS IN ARCHAEOLOGICAL SITES IN GOIÁS STATE: The Serranópolis and Palestina de Goiás CaseABSTRACTThe archaeological sites in Serranópolis and Palestina de Goiás counties, in the Southwest of the State of Goiás have been impacted by natural processes and anthropic action. The preliminary diagnosis of the GO-JA-13 and GO-CP-16 archaeological sites presents erosive processes, deforestation and cattle raising as the main causes. Corrective measures suggest isolating the contribution areas and stabilizing the erosive processes by means of superficial and sub-superficial water drainage and the containment of erosive action caused by water at the base of the slope and the ravine, as well as systematic monitoring.Keywords: Anthropic action; Archaeological diagnosis; Archaeological site protection.
ZOOARQUEOLOGIA DE VERTEBRADOS: Sítio Arqueológico Abrigo do Palmito, Caetité, Bahia
Authors: Santana Cristiana De Cerqueira Silva , Souza Maria Fatima Barbosa , Vieira Noelia Souza , Nicola Patricia Avello
Published: August 2018

Este trabalho teve por objetivo identificar os componentes faunísticos do Sítio Abrigo do Palmito, localizado no distrito Brejinho das Ametistas, município de Caetité, Bahia. São apresentados e discutidos dados taxonômicos e tafonômicos relacionados aos restos arqueofaunísticos encontrados durante as escavações do sítio, de modo a fornecer subsídios para a compreensão dos modos de exploração dos recursos e da composição da fauna na região. Os resultados evidenciam a predominância de restos de mamíferos de pequeno e médio porte, seguidos por répteis e anfíbios. As análises tafonômicas evidenciaram ações humanas, como marcas de corte. Os resultados indicam que o sítio foi habitado por grupos de caçadores-coletores especializados na caça de pequenos animais para fins alimentares. ZOOARCHEOLOGY OF VERTEBRATES: Archeological Site -Shelter of Palmito, Caetité, BahiaABSTRACTThe objective of this study was to identify the faunistic components from Archaeological Site Abrigo do Palmito, situated in the Brejinho das Ametistas District, city of Caetité, state of Bahia. Taxonomic and tafonomic data related to archaeofaunistic remains recovered in the excavation are presented and discussed in order to support the understanding the sources of explorations and, the faunal composition. The results evidenced the predominance of small and medium sized mammals followed by reptiles and amphibians. Tafonomic analyzes evidenced human actions as cut marks. These results obtained indicate that this site was inhabited by groups specializing in the hunting os small animals for food purposes.Keywords: Archaeofaunas; Taphonomy; Faunistic remains.
ENTREVISTA: PROFESSORA SÔNIA TATUMI
Authors: Maior Paulo Martin Souto
Published: August 2018

Formada em Física pela PUC de São Paulo, a Professora Sônia Tatumi estudou durante seu mestrado e doutorado temas relacionados às datações de estalagmites e à dosimetria termoluminescente. Em sua livre docência aproximou-se mais ainda da área de arqueologia ao estudar o tema As Técnicas da Termoluminescência e Luminescência Opticamente Estimulada Aplicada à Datação de Sedimentos e Cerâmicas Arqueológicas. Atualmente é pesquisadora da Universidade Federal de São Paulo e está vinculada aos programas de Pós-graduação do Instituto de Saúde e Sociedade, da UNIFESP, e do Departamento de Engenharia Elétrica, da EPUSP.
PERFIL CONSTRUTIVO DAS FORTIFICAÇÕES PORTUGUESAS DA CAPITANIA DE PERNAMBUCO ATÉ 1630
Authors: Matos Manuela Xavier Gomes de , Maior Paulo Martin Souto
Published: August 2018

O perfil construtivo de três fortificações da antiga Capitania de Pernambuco nas primeiras décadas do século XVII, período anterior à ocupação holandesa, revelou, através de dois remanescentes (Forte de São Francisco da Barra, de 1606, e Forte de São Francisco de Olinda, de 1620) e de iconografias (Forte de São Jorge, de 1590), que essas construções foram influenciadas por modelos descritos em tratados de fortificação europeus da época. Além do mais as adaptações à realidade de material, mão de obra, recursos e postura colonizadora impuseram certas restrições e adaptações. Identificar essas transformações foi o objetivo principal desta pesquisa. CONSTRUCTIVE PROFILE OF PORTUGUESE FORTIFICATIONS IN CAPITANIA OF PERNAMBUCO UNTIL 1630ABSTRACTThe constructive profile of three fortifications of the Captaincy of Pernambuco in the first decades of the 17th Century, before the Dutch occupation, revealed, through two remnants (Forte de São Francisco da Barra, 1606, and Fort de São Francisco de Olinda, 1620) and of iconographies (Fort de São Jorge, 1590), that these constructions were influenced by models described in European fortification treaties. Moreover, adaptations to the reality of material, labor, resources and colonizing posture have imposed certain restrictions and adaptations. Identifying these transformations was the main objective of this research.Keywords: Fortifications; 17th century; Pernambuco
Limitations and improvements of the energy balance closure with reference to experimental data measured over a maize field
Authors: MASSERONI DANIELE , CORBARI CHIARA , MANCINI MARCO
Published: August 2018

The use of energy fluxes data to validate land surface models requires that energy balance closure conservationis satisfied, but usually this condition is not verified when the available energy is bigger than the sumof turbulent vertical fluxes. In this work, a comprehensive evaluation of energy balance closure problems isperformed on a 2012 data set from Livraga obtained by a micrometeorological eddy covariance station locatedin a maize field in the Po Valley. Energy balance closure is calculated by statistical regression of turbulentenergy fluxes and soil heat flux against available energy. Generally, the results indicate a lack of closure witha mean imbalance in the order of 20%. Storage terms are the main reason for the unclosed energy balance butalso the turbulent mixing conditions play a fundamental role in reliable turbulent flux estimations. Recentlyintroduced in literature, the energy balance problem has been studied as a scale problem. A representativesource area for each flux of the energy balance has been analyzed and the closure has been performed infunction of turbulent flux footprint areas. Surface heterogeneity and seasonality effects have been studied to understand the influence of canopy growth on the energy balance closure. High frequency data have beenused to calculate co-spectral and ogive functions, which suggest that an averaging period of 30 min may misstemporal scales that contribute to the turbulent fluxes. Finally, latent and sensible heat random error estimationsare computed to give information about the measurement system and turbulence transport deficiencies
Some variations of the rainfall in Mexico City from 1954 to 1988 and their statistical significance
Authors: BRAVO JOSÉ LUIS , AZPRA ENRIQUE , ZARRALUQUI VÍCTOR , GAY CARLOS
Published: August 2018

Some characteristics of the precipitation such as the beginning and end of the rainy season, as well as their spatial and temporal distributions are studied. The study included data from 23 climatological stations located in the Federal District for the period 1954-1988. Four variables related to the beginning and end of the rainy season were defined, namely the day of the first and last event with 10 mm of accumulated precipitation and the percentage of accumulated precipitation until Julian days 150 and 275. An analysis of variance and principal components was made with these variables, establishing that rainfall in the Federal District (which includes part of Mexico City and its surrounding areas) responds homogeneously through time to the presence of mesoscale meteorological phenomena. The results indicate that precipitation was lower at the beginning and end of the study period, and higher in the middle; additionally, the rainy season starts from west to east and ends from east to west, causing a longer season in the southwest than in the northeast. The spatial distribution shows the greatest rainfall in the southwest due to the effect of the nearby mountains, and the lowest in the northeast.
The impact of model resolution on simulated ambient air quality and associated human exposure
Authors: DE RIDDER KOEN , VIAENE PETER , VAN DE VEL KAREN , BRASSEUR OLIVIER , CHEYMOL ANNE , FIERENS FRANS
Published: August 2018

A simple numerical experiment to evaluate the influence of model resolution on estimates of ambient air quality and associated human exposure is presented. This is done based on annual mean NO2 concentration fields for the agglomeration of Brussels and surroundings, simulated by the deterministic urban/regional-scale AURORA model at a resolution of 1 km. These NO2 concentration fields were used to calculate domain-wide exposure, which is defined here as the population density-weighted concentration. It was found that exposure decreased by 38% when degrading the resolution of the model from 1 to 64 km. A straightforward analysis revealed that this exposure reduction could be explained by the covariance between the concentration and population density patterns.
O distanciamento entre as Normas de Auditoria e as práticas nos Tribunais de Contas
Authors: Azevedo Ricardo Rocha de , Lino André Feliciano
Published: August 2018

O artigo compara o conteúdo das Normas de Auditoria Governamental com os processos de auditoria que são efetivamente realizados nos diversos Tribunais de Contas brasileiros em relação às contas de governos municipais. Ainda, identifica o escopo de auditoria priorizado pelos Tribunais de Contas e se esta é realizada presencialmente. As práticas de auditoria realizadas por 105 Auditores de Tribunais de Contas foram coletadas e comparadas com a percepção de 344 contadores municipais a eles jurisdicionados. Os resultados apontam para baixa observação de uso padronizado de Normas de Auditoria Governamentais, dando evidências do gap regulação-prática. Complementa-se que o escopo de auditoria dos Tribunais de Contas é voltado à legalidade, com baixa atenção à auditoria presencial. O artigo discute as implicações das práticas de auditoria observadas sobre (i) o monitoramento da atual reforma na contabilidade pública, (ii) as informações consolidadas no Balanço do Setor Público Nacional (BSPN), e (iii) mecanismos de accountability no desenho de políticas públicas.
Comparando Transparência Passiva na esfera estadual: Executivo, Legislativo e Judiciário
Authors: Drehmer Amanda Finck , Raupp Fabiano Maury
Published: August 2018

O presente artigo compara no nível de transparência passiva os órgãos representantes dos três poderes do nível estadual (governo estadual, assembleias legislativas e tribunais de justiça). Além da avaliação das plataformas oferecidas pelas entidades analisadas para o cidadão colocar seu pedido de informação. Adicionalmente, foi enviada solicitação de informação foi encaminhada aos três poderes nos diversos estados da federação. Dos três poderes, os governos de estado foram os que apresentaram plataformas de acesso e-SIC mais desenvolvidas. Os resultados demonstram que os governos de estado estão mais avançados na transparência passiva em relação aos outros dois poderes. Contudo, de forma geral organizações dos três poderes no nível estadual possuem barreiras acesso a informações na transparência passiva e não atendem plenamente a legislação associada.
Coprodução na Garantia dos Direitos da Criança e do Adolescente: quando a necessidade local é propulsora de envolvimento
Authors: Braga Adham Magno da Costa , Espírito Santo Ivanilde De Sousa do
Published: August 2018

O estudo analisa o Sistema de Garantia de Direitos da Criança e do Adolescente como espaço de coprodução de ações e serviços, nos eixos de promoção, defesa e controle. Foram realizadas entrevistas semiestruturadas e observação dos atores do Estado e da sociedade do sistema no município de Capanema/PA. Observou-se que o envolvimento com coprodução no município varia de acordo com o tipo de ação (promoção, defesa ou controle) tratada. Apesar do envolvimento em debates públicos, como contra o trabalho infantil e violência sexual, ainda que influenciem o desenho de políticas públicas, tais ocasiões não levam ao fortalecimento da coprodução. Os atores do Estado falham em se articular em rede, e o conselho gestor municipal (de Direitos da Criança e do Adolesceste), apesar de percebido como um espaço de debate democrático de políticas públicas, carece de envolvimento dos seus próprios membros.
Trajetórias institucionais, Controle Social e Rejeições de Contas Municipais
Authors: Silva Fernando Amorim da , Moretto Neto Luis
Published: August 2018

As decisões de agentes políticos em alguns municípios brasileiros costumam resultar em penalizações pelos órgãos de controle. Essas penalidades, contudo, podem variar com a atuação do controle externo e do controle social que influenciaram as escolhas dos agentes políticos. O presente artigo analisou o efeito de diferentes trajetórias institucionais e respectivo controle social em municípios de Santa Catarina, considerando as penalidades impostas pelo Tribunal de Contas do Estado. A análise observou as rejeições de contas dos municípios entre 2003 e 2016. Os resultados indicam que as microrregiões com maior e menor percentual de rejeições de contas apresentaram trajetórias histórias distintas, que podem ter influenciado no desenvolvimento de suas instituições e do controle social sobre a gestão pública.
ANGLO-AMERİKAN HUKUKUNDAN KITA AVRUPASI HUKUKUNA – ÖZEL HUKUKTA DE MINIMIS KURALI
Authors: ÖZDEN MERHACI Selin , ERKAN Vehbi Umut
Published: August 2018

Karşılaştırmalı
hukukun işlevsel denklik ilkesi bir hukuk düzeninde somut hukuki soruna
getirilen çözümden yola çıkılarak, bir başka hukuk düzeninde o kuruma işlevsel
olarak denk hukuk kurumlarının tespitini gerektirir. 

De minimis,  özellikle Amerikan hukukunda sıklıkla yargı
tarafından başvurulan bir kurumdur.  Bu
kurum, önemsiz zararların tazmin edilmemesini veya dava edilememesini
sağlamaktadır. Buna karşılık yazılı hukuk kurallarını hukukun birincil kaynağı
olarak kabul eden kıta Avrupası ülkelerinde açıkça de minimis kuralı olarak nitelendirebileceğimiz bir kurala
rastlanmamaktadır.

         Anglo-Amerikan
hukukunda sıklıkla kullanılan bu kurumun, kıta Avrupası hukuk düzenlerinde
birebir karşılığı bulunmasa da, karşılaştırmalı hukuk bakış açısıyla
yaklaşıldığında aynı işlevi gören kuralların izlerini tespit etmek mümkündür.
Özellikle haksız fiiller ve komşuluk hukukundaki bazı düzenlemelerin, önemli ve
önemsiz zararlar ayrımı yaptığı görülmektedir.Avrupa
Birliğinde bazı alanlarda hazırlanan direktifler, üye ülkelerin bu kurumu iç
hukuklarına almaları sonucunu doğurmuştur. Bunlardan en bilinenleri rekabet
hukukuna ilişkin düzenlemeler, ayıplı ürünlerin neden olduğu zararlardan doğan
düzenlemeler ve fikri haklar alanında yapılan düzenlemelerdir.

De Minimis kuralına
Avrupa’da hukukun birleştirilmesi çalışmaları kapsamında da yer verildiği
görülmektedir. Nitekim bu gelişmeler altında de minimis kuralı kıta Avrupası hukuklarına yabancı bir kurum
değildir.
Integrative Approach to Teaching of the Circuit Design of Analog Electron Devices in the NI ELVIS Platform
Authors: Stukach Oleg V. , Mirmanov Arman B.
Published: August 2018

Modern graduates need to work with electronic devices. On laboratory work, students conduct experiments to solve practical problems of researching real problems that arise in the design and operation of electronic devices. However, the shortage of laboratory equipment and assistants for maintenance and assistance in work, its high cost reduce the quality of laboratory work. On the other hand, modern education is increasingly using a network resource. Virtual laboratories have their advantages, but even when carrying out a physical experiment in them, the sense of the reality of what is happening disappears. Effective solutions to the effectiveness and quality of conducting laboratory exercises can be found using a system of virtual instruments that can be accessed via the Internet or directly at the university.

The aim of the research is to show, by the example of one experimental device made on the National Instruments ELVIS platform, the advantages of a combined approach to learning – a successful combination of a virtual resource and a real physical experiment. The laboratory model described in the article is very practical for studying radio-engineering devices, and it can ideologically serve as a basis for other similar developments.

The research was based on the prototype board for studying the basics of analog electronics for the NI ELVIS workstation, the cycle of laboratory work on the general technical discipline “Electronics”, the results of their protection, and the results of intermediate student controls. In work the following methods are used: laboratory experiment, modeling, pedagogical testing. The results of the research show that students feel the need for more knowledge about real processes and systems. This need is most evident in the direction of the preparation of bachelors of engineering and technology. They expect from a laboratory work a real physical experiment, but with the convenience of computer-processing results. A new paradigm for studying radio electronic devices, based on physical experiments in a virtual instrument system gives an improvement in the quality of instruction and allows students to study the circuitry of analog devices more effectively. The ideology of virtual instruments leads to more motivation for students; they gain skills to work with modern measuring equipment and at the same time communication skills in a group, as the computer resource is used as a research tool, not the purpose of learning.

A physical experiment, using virtual measuring instruments, accessibility and mobility of laboratory facilities, additional motivation of students are the main advantages of using the NI ELVIS hardware and software platform with a specialized breadboard model in the educational process.
Budding Alliance of Nanotechnology in RNA Interference Therapeutics
Authors: Kumawat Akshant , Dapse Prachi , Kumar Narendra , Mishra Dinesh Kumar , Maheshwari Rahul , Bhattacharya Pallab , Tekade Rakesh Kumar
Published: August 2018

RNA interference (RNAi), as a novel technique in which RNA molecules limit or silence the gene
expression, is currently a hot research topic for producing novel therapeutic materials for challenging diseases. In
the development of RNAi-based therapies, nanoscale particles, with a varying diameter along with facile modification
methods that can mediate effective RNAi with targeting potential, are gaining wide interest. The nanotechnology
itself has tremendous potential in the field of healthcare, especially for the development of better pharmaceuticals.
Nano-enabled delivery has shown great success in the delivery of RNAi based therapeutics to specific
locations in the body. Especially, siRNAs show great potential for use in nucleic acid therapeutics because of
their potent and specific RNAi-triggering activity. This review summarizes the advanced nanocarriers such as
solid lipid nanoparticles, gold nanoparticles, silver nanoparticles, iron oxide nanoparticles, polymeric nanoparticles,
nanotransformers and curdlan nanoparticles with special emphasis on various aspects of siRNA-based therapeutics.
Computational and Experimental Progress on the Structure and Chemical Reactivity of Procyanidins: Their Potential as Metalloproteinases Inhibitors
Authors: Mendoza-Wilson Ana María , Balandrán-Quintana René Renato
Published: August 2018

Matrix metalloproteinases (MMPs) are enzymes involved in various physiological processes essential for living beings, but the loss of the regulatory control by endogenous inhibitors of MMPs, leads to the development of serious diseases such as cardiovascular system affections, cancer, and metastasis. For these reasons, exogenous inhibitors are required for these enzymes, which are able to control the proteolytic activity and are selective towards the different MMPs, besides properties which, from the pharmacological point of view, are necessary to be effective under physiological conditions. Based on these expectations, some bioactive compounds that are abundant in the human diet, like procyanidins (PCs) have emerged as potential exogenous inhibitors of MMPs. This review presents the advances of experimental and computational investigations carried out to date on the structure and chemical reactivity of PCs, to support the basis of their potential use as MMP inhibitors. For such purpose, specific sites among MMPs identified for a selective inhibition, the role of PCs in the regulation of MMPs by posttranscriptional mechanisms at the level of microRNAs, modulation of reactive oxygen species (ROS), effects on tissue inhibitors of MMPs (TIMPs), the crosslinking of PCs with the extracellular matrix proteins, as well as direct interaction between PCs and MMPs, are discussed. Methods for isolation and synthesis of PCs, as well as hydrophilicity properties, bioavailability, and susceptibility to be metabolized in oral intake, are also addressed. The information gathered in this review could additionally help to visualize future research related to this topic.
Synthesis and Characterization of a Novel Ionic Liquid Based on N,N,N,N-tetramethylethylenediamine and its Application in the Synthesis of 1,8-dioxo-octahydro Xanthenes
Authors: Piralghar Zahra Abdi , Hashemi Mohammad Mahmoodi , Ezabadi Ali
Published: August 2018

Aim and Objective:

In this work, we synthesized and characterized a novel Brönsted
acidic ionic liquid from the reaction of N, N, N’, N’-tetramethylethylenediamine with chlorosulfonic
acid and explored its catalytic activity in 1, 8-dioxo-octahydroxanthenes synthesis.

Materials and Methods:

Dimedone, aryl aldehydes, and the ionic liquid as the catalyst were reacted
under solvent-free conditions. The progressive of the reaction was monitored by a thin layer of
chromatography (ethyl acetate/n-hexane = 1/5). All products were characterized as the basis of their
spectra data and melting point by comparison with those reported in the literature.

Results:

The prepared ionic liquid was successfully applied in the synthesis of 1, 8-dioxooctahydroxanthenes
in good to high yields on the reaction of aryl aldehyde and dimedone at 120oC
under solvent-free conditions.

Conclusion:

This research demonstrates that the catalyst is impressive for 1, 8-dioxo-octahydroxanthenes
synthesis under solvent-free conditions.
Molecular Mechanism of Aniline Induced Spleen Toxicity and Neuron Toxicity in Experimental Rat Exposure: A Review
Authors: Makhdoumi Pouran , Hossini Hooshyar , Ashraf Ghulam Md , Limoee Mojtaba
Published: August 2018

Aniline exposure leads to neuron and spleen toxicity specifically and makes diverse neurological effects and sarcoma that is defined by splenomegaly, hyperplasia, and fibrosis and tumors formation at the end. However, the molecular mechanism(s) of aniline-induced spleen toxicity is not understood well, previous studies have represented that aniline exposure results in iron overload and initiation of oxidative/nitrosative disorder stress and oxidative damage to proteins, lipids and DNA subsequently, in the spleen. Elevated expression of cyclins, cyclin-dependent kinases (CDKs) and phosphorylation of pRB protein along with increases in A, B and CDK1 as a cell cycle regulatory proteins cyclins, and reduce in CDK inhibitors (p21 and p27) could be critical in cell cycle regulation, which contributes to tumorigenic response after aniline exposure. Aniline-induced splenic toxicity is correlated to oxidative DNA damage and initiation of DNA glycosylases expression (OGG1, NEIL1/2, NTH1, APE1 and PNK) for removal of oxidative DNA lesions in rat. Oxidative stress causes transcriptional up-regulation of fibrogenic/inflammatory factors (cytokines, IL- 1, IL-6 and TNF-α) via induction of nuclear factor-kappa B, AP-1 and redox-sensitive transcription factors, in aniline treated-rats. The upstream signalling events as phosphorylation of IκB kinases (IKKα and IKKβ) and mitogen-activated protein kinases (MAPKs) could potentially be the causes of activation of NF-κB and AP-1. All of these events could initiate a fibrogenic and/or tumorigenic response in the spleen. The spleen toxicity of aniline is studied more and the different mechanisms are suggested. This review summarizes those events following aniline exposure that induce spleen toxicity and neurotoxicity.
Antibacterial Flavonoids Against Oral Bacteria of Enterococcus Faecalis ATCC 29212 from Sarang Semut (Myrmecodia pendans) and Its Inhibitor Activity Against Enzyme MurA
Authors: Kurnia Dikdik , Apriyanti Eti , Soraya Cut , Satari Mieke H.
Published: August 2018

Background:

A significant number of antibiotics are known to inhibit peptidoglycan synthesis
in the cross-linking stage, while the drug fosfomycin is the only one known to inhibit MurA.
Escalated antibiotic resistance has had an impact on the efficacy of fosfomycin, thus demanding the
discovery of suitable substitutes with improved potential for MurA inhibition. The aim of this work
is to isolate antibacterial compounds from Sarang Semut (Myrmecodia pendans) and to evaluate their
antibacterial activity against pathogenic oral bacteria of Enterococcus faecalis ATCC 29212 and inhibitory
activity against MurA enzyme.

Methods:

The antibacterial compounds from Sarang Semut were isolated by a bioactivity-guided
separation method with various solvents and combination of column chromatography on normal and
reverse phases. The compounds with concentrations of 1000 and 5000 ppm were assessed against
E. faecalis ATCC 29212 by agar well diffusion method, with chlorhexidine and fosfomycin being
used as positive controls.

Results:

Two antibacterial compounds isolated from Sarang Semut were identified as two new flavonoids
derivates of 1 (10 mg) and 2 (4 mg). Both compounds were tested for antibacterial activities
against E. faecalis. MIC values of compounds 1 and 2 were 8.15 and 8.05 mm at 1000 ppm and 8.62
and 8.55 mm at 5000 ppm, respectively. MBC values were 156 and 625 ppm for 1 and 625 and 2500
ppm for 2, respectively. In an inhibitory murA enzyme activity assay, compounds 1 and 2 were
shown to inhibit the enzyme activity by IC50 values of 21.7 and 151.3 ppm.

Conclusion:

The study demonstrated that ethyl acetate fraction of Sarang Semut contained antibacterial
flavonoids as active constituents that showed activity against E. faecalis. These results showed
the plant’s potential in herbal medicine and the development of new antibacterial agent for pathogenic
dental caries.
A Brief Literature and Review of Patents on Thiazole Related Derivatives
Authors: Sharma Diksha , Bansal Kushal K. , Sharma Archana , Pathak Meenakshi , Sharma Prabodh C.
Published: August 2018

Background:

Thiazole is widely investigated bioactive scaffold and dynamic tool in medicinal chemistry research. Significance of thiazole compounds are well documented as thiazole is an obligatory structure of number of currently available therapeutics. In spite of that, thiazole derivatives are endowed with myriad biological activities, such as antiviral, anticancer, antibacterial, antifungal, antimalarial, antiparkinsonian, anti-inflammatory activities and many more.

Methods:

In recent past, different approaches have been introduced for synthesis of thiazole and related compounds. Intrinsic molecular interaction between newly synthesized thiazole compounds and plethora of drug targets/enzymes has rendered discovery of new drug molecules with advances in modes of action. A renewed interest in therapeutic use of thiazole derivatives has been seen among the prospective researchers as exemplified by influx of huge scientific articles and patents. Some important patents of anti-infective and anticancer interest have been addressed appropriately and are presented in tables.

Results:

This review paper is a contemporary approach on therapeutic/applications of thiazole derivatives by summarizing important patents filed from 2000-2017. The main focus of these patents is on anti-infective and anticancer potential of thiazole based compounds.

Conclusion:

These approaches may provide valuable information for the further design of more active biological agents through various modifications and derivatizations.
Cariprazine in Bipolar Depression and Mania: State of the Art
Authors: Mazza Marianna , Marano Giuseppe , Traversi Gianandrea , Carocci Valentina , Romano Benedetta , Janiri Luigi
Published: August 2018

Background & Objective: Cariprazine is a piprazine derivative approved by the FDA in
2015 for the treatment of schizophrenia and bipolar manic or mixed episodes in adults. High affinity
for D3 dopamine receptors and observed actions on 5HT1A, 5HT2A and alpha 1B receptors differentiate
it pharmacologically from other antipsychotics. This review is a comprehensive and thorough
summary of the most important findings on cariprazine use in bipolar mania and depression. Pharmacokinetics,
pharmacogenetics, tolerability and safety adverse effects are discussed in this paper.

Results & Conclusion:

Moreover, the results from pivotal clinical trials are presented. Cariprazine represents
an additional option for clinicians to treat patients with bipolar disorder. It shows a unique pharmacological
profile and has demonstrated in randomized clinical trials efficacy and general tolerability compared
to placebo in bipolar mania and seem to be a promising therapeutic option for bipolar depression.
Guislain
Authors: Kluyskens Pierre
Published: August 2018

Pierre Kluyskens schreef deze hommage 65 jaar geleden.
Vraag en antwoord
Authors: Collumbien Hugo
Published: August 2018

Antwoord op een vraag over de locatie van de Banque de Flandre.
Bibliografie - GT 2013 nr 3
Authors: Collumbien Hugo
Published: August 2018

“Met brieven van de wet. Stedelijk briefverkeer in het laatmiddeleeuws graafschap Vlaanderen.” MGOG

“Oud Vlaendre op de Wereldtentoonstelling van 1913 opnieuw bezocht.” Rudy Claerman

“3500 Huisnamen te Gent en elders vermeld in de Gazette van Gend(t) (1749-1800).” Georges Souffreau
Minder bekende Gentse notabelen uit de periode 1780-1840 (vervolg)
Authors: Schrans Guy
Published: August 2018

In opvolging van een reeks artikelen die in 2010-2012 in dit tijdschrift verschenen.
Per huurbootje doorheen de stad. Vigilanten te water in 1881.
Authors: Devriese Luc
Published: August 2018

Ooit ging het er anders aan toe. Je kon ook in het stadscentrum een bootje huren, maar dan niet om je stad te bezichtigen van op het water. Niemand dacht er aan zoiets extravagants te ondernemen, tenzij misschien een zeldzame in Gent verdwaalde excentrieke Engelsman. Je kon er wel een en ander mee vervoeren over de vele Gentse watertjes om misschien een van op straat moeilijk bereikbaar achterhuis te bevoorraden, enz. In elk geval om ‘iets nuttigs’ te doen.
Water: Gesel of zegen?
Authors: De Keukeleire Erik
Published: August 2018

VOOR U VERZAMELD UIT 31600 EDITIES VAN DE GAZETTE VAN GENT
De stedelijke Braemmolens aan de Brabantdam.
Authors: Devriese Luc
Published: August 2018

In Gent vormde het Braemgatencomplex met de Braemmolens aan de Brabantdam bij de Braempoort een van de belangrijkste stuwen. De vroegste vermelding als brug dateert van 1199.
Over de paviljoenen van de Wereldtentoonstelling 1913
Authors: De Coster X
Published: August 2018

Van al de vreemde afdeelingen was de Nederlandsche de eerste volledige afgewerkt en gereinigd, en dat te danken aan het werk van de CENTRALE COMMISSIE, maar ook aan de tentoonstellers.
Herman Bang. Deens bezoek aan het Groot Begijnhof (1880).
Authors: Van de Maele Romain John
Published: August 2018

Bang was een van de auteurs die, samen met Hendrik Pontoppidan en anderen, tijdens het laatste kwart van de negentiende eeuw de vernieuwing van de Deense letterkunde hebben ingeluid.
Nog herkenbaar? De Iepenstraat bij de Zandpoort en de Houtlei
Authors: Devriese Luc
Published: August 2018

We nodigen je uit om aan de hand van de hierbij gereproduceerde afbeeldingen, nieuw met oud te vergelijken aan het uiteinde van de Gebroeders Van De Veldestraat bij de Oude Houtlei, net voor de bocht naar de Annonciadenstraat straat, richting Rozemarijnbrug.
Armoedige straatjes en beluiken in de Overpoortbuurt.
Authors: Devriese Luc
Published: August 2018

De hele zone tussen de Overpoortstraat en de Schelde achter het Kramersplein met de oude stadsschool (nu Liberaal Archief) was tot in de jaren 1970 een sjofele volksbuurt met kleine straatjes.
Lezers aan het woord. Verschenen.
Authors: Devriese Luc
Published: August 2018

Verschenen boeken :

'Van Andriesschool tot Zondernaamstraat',  Bart D’hondt

'Van Mensen & Dingen' 2014 nr. 4: publieke toiletten, detoxen, sexcinema Leopold III, militaire eretekens W.O. I en een carnavalsviering in 1884
Inventaire archéologique - fiche nr. 346. L'Escalier régence.
Authors: Devriese Luc
Published: August 2018

Onder de titel ‘terme d’escalier régence’ stelde Armand Heins in 1904 een fiche op over een trapkolom bewaard in het Archeologisch Museum van de stad, destijds in de kapel van het Caermersklooster in het Patershol.
Huis De Baerdemaecker, Désiré Fiévéstraat nr. 34.
Authors: Van Ryssel Daniël
Published: August 2018

De straat van Nieuwland tot het Stapelplein met het hier besproken huis werd genoemd naar Désiré Fiévé (Gent 1825-1908), houthandelaar, grondeigenaar, rechter bij de handelsrechtbank, katholiek volksvertegenwoordiger en senator. Ze werd in 1857 dwars doorheen zijn eigendom getrokken. Het straatbeeld wordt bepaald door magazijnen en opslagplaatsen (dichtbij de haven) en huizenblokken van arbeiders en kleine burgerhuizen.
Straffe toeren (1820-1824).
Authors: Devriese Luc
Published: August 2018

Gesprokkeld en vertaald uit de Mémorial de la Ville de Gand 1790 -1830 van Prosper Claeys, Gent, 1902. Met hier en daar een klein kommentaartje ter verduidelijking.
Edith Cavell in Gent.
Authors: De Decker Arthur
Published: August 2018

Op 12 oktober 1915 werd de Britse verpleegster Edith Cavell (1865-1915) te Schaarbeek gefusilleerd door een Duits vuurpeloton. Zij staat bekend als verpleegster die een humanitair ontsnappingsnetwerk voor geallieerde militairen opzette en werd daarvoor ter dood veroordeeld door de Duitse bezetter. Cavell is één van de symboolfiguren van de Eerste Wereldoorlog.
Hoe schrijf ik mijn dialect?
Authors: Levis Eddy
Published: August 2018

Om het Gentsch dialect neer te schrijven, zou het alfabet moeten vermeerderd worden, zegt men. Dit geeft ons de gelegenheid eventjes een boompje op te zetten over dialectspelling.
Loonboekje - Loonzakje
Authors: Rouquart Willy
Published: August 2018

Bij de foto van een loonboekje (18,3 x 13,5 cm). De betrokkene werd wekelijks betaald (6 dagenweek) en verdiende bv. in de 3de week van 1936 (van 13 t/m 18 januari) 114,25 BEF. Achteraan is van de kaft een zakje gemaakt waarin het geld werd gestopt.
Gentse keldercafés.
Authors: Devriese Luc
Published: August 2018

Hier en daar kan je er nog in neerdalen, iets bestellen en gezellig samen zitten, maar ooit waren er veel meer in het Gentse stadscentrum: drankgelegenheden in kelders. In straten zoals de Hoogpoort verhuurden nogal wat eigenaars de oude kelders onder hun ‘stenen’ en andere oude huizen als café, soms dancing (maar dan vooral voor slows op één enkele tegel).
Brusselsepoortstraat nr. 142. Een huis met een rijke geschiedenis
Authors: De Smet Tineke
Published: August 2018

De aankoop in 2004 van een huis in de Brusselsepoortstraat vormde de aanleiding tot een zoektocht naar wat er achter de stenen verborgen zit. Hoe zag het er daar uit, een eeuw, meerdere eeuwen geleden?
The Fallen Angels, Jan Breidelstraat 29-31, een bouwhistorisch onderzoek
Authors: Goeminne Koen
Published: August 2018

De woning die in deze beschrijving van een bouwhistorisch onderzoek aan bod komt, draagt het huisnummer Jan Breydelstraat 29-31 en is gebouwd op de kadasterpercelen 3062a en 3062a bis. Vandaag staat dit gebouw bekend als de The fallen Angels, een winkeltje waar men naast oude dinky toy autootjes en vintage postkaarten vooral ondergedompeld wordt in een wereld van nostalgie en curiosa,
Voor haard en land 1914-1915. Gentenaars uit de christelijke arbeidersbeweging in de grote oorlog.
Authors: Dekeyser Erik
Published: August 2018

Een opleidingskamp te d’Auvours (Centre d’Instruction d'Infanterie n° 7) voor Belgische infanteriesoldaten bevond zich 12 km ten oosten van Le Mans. Op het einde van 1914 werd deze plaats het belangrijkste opleidingscentrum voor de infanterie van het Belgische Leger (5 à 6000 manschappen, vooral Vlamingen).
Clave para la identificación de géneros de thrips (Insecta: Thysanoptera) comúnmente asociados a plantas ornamentales en Centroamérica
Authors: Soto-Rodríguez Gerardo A. , Rodríguez-Arrieta Jesús Alexander , González Muñoz Carlos , Cambero-Campos Jhonathan , Retana-Salazar Axel P.
Published: August 2018

Se presenta una clave ilustrada de especies de tisanópteros encontradas en plantas ornamentales de Costa Rica, Cuba y México, con referencias de especies presentes en la Argentina y la Península Ibérica. La clave incluye un total de 21 especies, de las cuales 16 pertenecen al suborden Terebrantia y cinco al suborden Tubulifera. Para todas las especies se indican los sitios de recolección y la planta hospedadora correspondiente.
Dieta y ámbito hogareño del gato feral, Felis catus (Carnivora: Felidae) en la Isla Socorro, Archipiélago de Revillagigedo, México
Authors: Ortiz-Alcaraz Antonio , Arnaud Gustavo , Aguirre-Muñoz Alfonso , Galina Tessaro Patricia , Méndez-Sánchez Federico , Ortega-Rubio Alfredo
Published: August 2018

Isla Socorro es una isla oceánica rica en biodiversidad y endemismos. Sin embargo, la isla ha sido impactada por el gato asilvestrado desde 1957. A través del análisis del contenido estomacal de 79 gatos se determinó la dieta de este depredador, la cual está constituida mayormente por el ratón doméstico (Mus musculus, 22.16%), la lagartija endémica (Urosaurus auriculatus, 15.09%), residuos antropogénicos (15.09%), e insectos (Orthoptera, 13.20%). Se identificó el ámbito hogareño de los gatos a través de telemetría, utilizando cuatro individuos con radio-collares GPS/VHF. El ámbito hogareño de los machos resultó de 219.10 ha en promedio, mucho mayor que el de las hembras que fue de 118.86 ha. Conocer el ámbito hogareño del gato asilvestrado de Isla Socorro es clave para la erradicación exitosa de la población de la isla. Gracias a esta información se ha podido calcular el esfuerzo de trampeo o la cantidad de carnada que deben ser empleadas por unidad de área durante la erradicación en curso, que es relevante para la conservación de la biodiversidad global.
Primera cita de los jumiles comestibles Edessa bifida y Edessa championi (Hemiptera: Pentatomidae) y su importancia en la cultura entomofágica en la comunidad rural de “El Zompantle”, Taxco de Alarcón, Guerrero, México
Authors: Silva-García Francisca , Figueroa-Castro Pedro , López-Martínez Victor , Pérez-Villalba Elba
Published: August 2018

Se presenta por primera vez el reporte de dos jumiles comestibles Edessa championi (Distant 1881) y Edessa bifida (Say 1832) (Hemiptera: Pentadomidae), en la comunidad rural “El Zompantle”, de Taxco de Alarcón, Guerrero. También se realizó un estudio corto de su importancia en la cultura entomofágica de las familias de la comunidad.
Sub-classification Processes of the Cul-de-sac Courtyards
Authors: Ibrahim Bajunid Anniz Fazli , Abbas Mohamed Yusoff , Nawawi Abdul Hadi , Rameli Alias
Published: August 2018

Shah Alam has exhibited flourishing cul-de-sac courtyard neighbourhoods, which has stirred debatable interests. The objective of this paper is to continue the discourse in measurable analysis of sub-classifications. The paper assembles physical data with key characteristics that make up the physical construct of a cul-de-sac courtyard by administering measurements, observations and checklists. The sub-classification processes led to preliminary key factors such as density, size, design forms and user implications. 18 cul-de-sac courtyards in Shah were catalogued and inventoried, elucidating its syntax. The database introduced potential in longitudinal research of the socio-spatial micro-neighbourhood unit, towards pragmatic applications in emergent design practices.
The Cycle of Bazaar in Heritage Open Space: Aloon-aloon Johar Area, Semarang
Authors: Rukayah R. Siti , . Bharoto , Malik Abdul
Published: August 2018

Retail globalization resulting in the modern building gives the influence to modernize bazaar. Is it appropriate if the government uses the same method when the bazaar cycle consecutively happens in Johar in the 1930s and 1970s when modern retail buildings were ineffectively used? There is no theory that can explain this phenomenon. The modern retail building is like a leaky container. Initially, the concept of retail in the United Kingdom is like a bazaar. The bazaar in Semarang was a tourist destination in 1950 just like a bazaar in other countries now. Next collaboration research needs to conduct with the United Kingdom and other countries that make the bazaar a tourist asset.
ÖZ-BİLİNÇ ALGISININ OLUMLU GELECEK BEKLENTİSİNE ETKİSİ: POZİTİF PSİKOLOJİ VE KAYNAK ODAKLI YAKLAŞIM ARKA PLANI İLE BİR DEĞERLENDİRME
Authors: YURTKORU Serra , TAŞTAN Seçil
Published: August 2018

Amaç: Bu çalışmada,
öz-bilinç ve
olumlu gelecek beklentileri kavramları ele alınmış ve öz-bilincin bireylerin
geleceğe dair beklentilerindeki rolünü ortaya çıkarmak amaçlanmıştır.

Yöntem: Bireylerin öz-bilinç düzeylerinin
geleceğe ilişkin olumlu beklentileri üzerindeki etkisinin incelendiği çalışma
yükseköğretim öğrencilerinden toplanan veriler üzerinden irdelenmiştir (N=280).
Öz-bilinç kavramı genel, özel ve sosyal anksiyete boyutlarıyla geleceğe ilişkin
olumlu beklentiler kavramı ise olumlu gelecek yönelimi, sağlık-yaşam kalitesi,
meslek-kariyer beklentileri ve kişisel başarı-yeterlilik boyutlarıyla
ölçülmüştür.

Bulgular ve Sonuç: Yapılan çoklu
regresyon analizleri geleceğe ilişkin beklentilerin tüm boyutlarında özel
öz-bilincin olumlu ve anlamlı etkisi olduğunu ortaya koymuştur. Ayrıca sonuçlar
öğrencilerin geleceğe ilişkin olumlu beklentilerin de (M=4,25) öz-bilinç
düzeylerinin de (M=4,40) ortalamanın biraz üstünde olduğunu göstermektedir.