bluuebunny/crossref_metadata_2025 huggingface dataset:
Zinc deficiency alters metabolism-related organ crosstalk via changing insulin levels
Authors: Nakamura Anna , Kido Takamasa , Seki Yoshiko , Suka Machi
Published: February 2023

Zinc is one of the essential trace elements that plays an important role in the biological processes in human beings. Zinc deficiency, therefore, is known to cause several biofunctional disorders. Zinc plays an important role in stabilizing the pancreatic insulin secretion. Insulin not only exerts a hypoglycemic effect, but also regulates glucose and lipid metabolisms in insulin-target organs. It, thus, regulates various metabolic diseases, as well. Zinc levels, in vivo, are reportedly related to metabolic diseases, for instance, zinc levels have been reported to regulate glucose and lipid parameters. However, no study, thus far, has explained the relationship of zinc with glucose and lipids on the basis of the concentration of insulin. In this study, a zinc-deficient rat model was developed to analyze how insulin levels, insulin-regulated glucose and lipid metabolisms, and their crosstalk are regulated. The findings from this study will help to clarify the role of zinc in insulin-regulated metabolic diseases.
WITHDRAWN: How leaders influence the turnover
Authors: Fiescho Thomas
Published: February 2023

This study is reflective of the cutting edge of knowledge in the expanding subject of leadership. In this study, we compare the effects of two different types of leadership—Responsible Leadership and Servant Leadership—on employees' propensity to leave their current positions. This report aims to investigate the connection between leadership styles and future turnover plans. Data from seven pharmaceutical firms in Himachal Pradesh, India, representing a total of 121 employees, were collected to complete this analysis. In terms of statistics, we employed an ANOVA and a descriptive method. The results of the study imply that there is a strong connection between responsible and servant leadership and employee aspirations to leave their current position. As a result, it is clear that servant leadership and its associated culture have a considerable and negative impact on employees' willingness to leave their current position.
Impact of Non-surgical Periodontal Treatment on Cytokines/Adipocytokines Levels Among Periodontitis Patients with or without Obesity: A Systematic Review and Meta-analysis
Authors: Zhang Yuwei , Jia Ru , Zhang Yifei , Sun Xuefei , Mei Yukun , Zou Rui , Niu Lin , Dong Shaojie
Published: February 2023

Aim
The objective of this systematic review and meta-analysis was to provide scientific evidence for clinical practice on the impact of non-surgical periodontal therapy (NSPT) on cytokines/adipocytokines (IL-6, TNF-a, CRP/hs-CRP, resistin, adiponectin, leptin and RBP4) among periodontitis patients with or without obesity.
Materials & Methods of Study Selection
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) has been followed. The study was registered (CRD42022375331) in the International prospective register of systematic reviews (PROSPERO). The literature search was conducted via eight databases. Both randomized-controlled trials (RCTs) and controlled clinical trials (CCTs) were screened from searches up to December 2022 to evaluate the effect of NSPT on inflammatory-related cytokines/adipocytokines. The selection, extraction of data and risk of bias assessment were performed in duplicate with consensus while quality was assessed via the Cochrane Collaboration’s risk assessment tool and the Methodological Index for non-randomized studies (MINORS). Meta-analysis was carried out using random-effect model in subgroups’ analyses with mean difference (MD) and 95% confidence intervals (CI) provided.
Results
Seventeen references were included for the systematic analysis and sixteen were further incorporated for meta-analysis. Meta-analysis demonstrated that the interleukin (IL) -6 in periodontitis individuals with obesity decreased three months after NSPT at serum levels (MD = -0.54, CI = -0.62 – -0.46) and at gingival crevicular fluid (GCF) levels (MD = -2.70, CI = -4.77 – -0.63); the C-reactive protein/ high-sensitivity-C-reactive protein (CRP/hs-CRP) decreased three months after NSPT at serum levels (MD = -0.31, CI = -0.54 – -0.07) and adiponectin improved three months after NSPT at GCF levels (MD = 2.37, CI = 0.29–4.45) both in periodontitis individuals without obesity. Most results displayed the higher level of pro-inflammatory biomarkers in obesity object rather than normal weight object at baseline. Incorporated studies are presented with low risk of bias.
Conclusions
NSPT has the impact on the redistribution of specific pro-inflammatory mediators and anti- inflammatory mediators in biological fluids within obesity or non-obesity individually or between the two groups. Wherein, NSPT could contribute to the reduction of serum and GCF IL-6 level together with the serum RBP4 level in obesity individuals at 3-month, NSPT also could contribute to the rise of GCF adiponectin level in normal weight individuals at 3-month, which implies the potential ideal follow-up interval and sensitive biomarkers for clinical bioanalysis.
Body Mass Index trends in men’s Grand Tour cycling events from 1992-2022: Implications for athlete wellbeing and regulatory frameworks
Authors: Smith Alexander , Wijnkoop Moritz van , Colangelo Jill , Buadze Anna , Liebrenz Michael
Published: February 2023

Background: Weight-related issues and adverse weight-management behaviours are prominent concerns in elite-level sports, notably in competitions like men’s road cycling. Whilst other sporting bodies have introduced measures based on Body Mass Index (BMI), no such provision exists in elite-level cycling, which is overseen by the Union Cycliste Internationale (UCI). However, these may be necessary to protect the short- and long-term health of riders and improve perceptions of the sport.
Methods: To ascertain the potential need for targeted policies, we gathered height and weight data from the ProCyclingStats website to investigate BMI trends for the top five male finishers between 1992-2022 in the General Classification (GC) category of the UCI’s Grand Tours: the Giro d’Italia, the Tour de France, and the Vuelta a España.
Results: We calculated the BMI of 156 unique top five finishers in the GC of the Grand Tours with a total of n=445 BMI values (this includes riders who had multiple top five finishes in different races and years). Whilst singular data points varied, we observed overall declining mean BMI trends for these cyclists between 1992-2022.
Conclusion: Our results supplement existing anecdotal and scholarly evidence and suggest that lower BMIs are increasingly associated with top finishing positions in the GC of the men’s Grand Tours. This could have substantial implications for athletes and regulators, since performance pressures could lead to detrimental weight-management practices that can harm short and long-term health and affect the sport’s reputation. Accordingly, we propose that the UCI could consider multifactorial interventions, including prevention and awareness campaigns, screening programs, and BMI-based guidelines.
Formation of amphibole lamellae in mantle pyroxene by fluid-mediated metasomatism: A focal plane array FTIR study from the Carpathian-Pannonian region
Authors: Liptai Nóra , Lange Thomas P. , Patkó Levente , Aradi László E. , Berkesi Márta , Tollan Peter M.E. , Padrón-Navarta José Alberto , Hermann Jörg , Gergely Szilveszter , Szabó Csaba , Kovács István J.
Published: February 2023

Amphiboles in the upper mantle (most frequently pargasitic in composition) have recently gained attention due to their role in the water budget and potential control on the rheology and physical discontinuity of layers of the mantle. Although nominally anhydrous minerals are often analyzed with Fourier transform infrared (FTIR) spectroscopy, amphiboles, especially in natural samples, are only rarely the focus of such studies because of their complex structure and variable composition. In mantle xenoliths, amphibole occurs not only interstitially or forming veins, but also as lamellae within orthopyroxene and/or clinopyroxene grains. The genesis of such lamellae is often ambiguous, as they could either be meta-somatic products, or form by exsolution without an external H2O source upon decreasing P-T conditions and consequent destabilization of hydrous point defects in the host pyroxene. To constrain the origin of amphibole lamellae in pyroxenes, we studied mantle xenoliths from the Carpathian-Pannonian region (CPR) by applying hyperspectral imaging using an FTIR equipped with focal plane array (FPA) detector. Amphibole lamellae are absent in xenoliths of the central part of the CPR, but appear in those from the marginal localities that represent a well-hydrated supra-subduction mantle environment. Some of the lamella-hosting pyroxene grains are in contact with interstitial amphibole, suggesting that the formation of the lamellae is related to the amphibole-producing metasomatism; however, others have no adjacent amphibole. To determine the origin of the amphibole lamellae in pyroxenes without neighboring amphibole, hyperspectral images were used to give an estimation of their volume proportion (0.8–5.1 vol%) in the pyroxenes. Using these volume proportions, we calculated that a bulk water content of ~330–670 (orthopyroxene) and ~740–1430 (clinopyroxene) wt. ppm is needed to be contained in the host grain to be able to facilitate subsolidus exsolution of the observed amount of amphibole lamellae. These water contents are, however, too high for mantle pyroxenes, even for an aqueous-fluid saturated upper mantle. This suggests that the formation of amphibole lamellae is related to a metasomatic event with fluid input from an external water source (e.g., melt/fluid inclusion or metasomatic agent on the grain boundary).
Gold-silver mineralization in metagabbroids of the Bazhenov ophiolite massif (Middle Urals)
Authors:   The Zavaritsky Institute of Geology and Geochemistry of the Ural Branch of RAS, Erokhin Yuriy Viktorovich
Published: February 2023

The relevance of the work is due to the need to study the conditions for the occurrence and distribution of precious metals in ophiolite massifs, which are often associated with gold placers. Purpose of work: Study of gold-silver mineralization from metagabbroids of the Bazhenov ophiolite massif (Middle Urals). Research methodology. The chemical composition of native gold and silver was obtained from polished thin sections of metagabbroids at the Institute of Geology and Geochemistry of the Ural Branch of the Russian Academy of Sciences (Еkaterinburg) on a CAMECA SX 100 electron probe microanalyzer with five wave spectrometers and using standard samples of reference minerals. Results. Native gold in metagabbroids composes poor and scattered dissemination. The metal forms isometric grains, no larger than 10 microns in size. According to microprobe analysis, native gold is quite fine and contains small impurities of silver (no more than 4 wt. %). Both gold and silver occur in sulfidized metagabbroids. Large ”gold pieces”, up to 50–60 microns in size, are noted in the aggregate of chalcopyrite and pyrite. According to microprobe profiling, they have a complex composition: gold passes into electrum, then into kustelite, and then into silver. Of the impurities, copper (up to 1.6 wt. %), iron (up to 1.1 wt. %) and mercury (up to 0.5 wt. %) are noted. Conclusions. In the metagabbroids of the Bazhenov massif, gold-silver mineralization was established in the form of native gold and silver, as well as their alloys – electrum and kustelite. The formation of gold and silver in metagabbroids is metamorphogenic in nature and no connection with acidic fluids has been established. Noble metals and their alloys crystallized at temperatures below 350°C, which corresponds to the bottom of the greenschist facies.
Electrical parameters of high-temperature electrical conductivity, frequency characteristics of active electrical resistance and dielectric losses of samples of minerals, rocks, ores as a function of their composition and genesis
Authors:   Bulashevich Institute of Geophysics of the Ural Branch of RAS, Bakhterev Vladimir Vasil’evich
Published: February 2023

Relevance is determined by the search and selection of the most information-intensive characteristics and physical properties of minerals and rocks for the reconstruction of genesis conditions, as well as the need for scientifically based criteria for the detection of various minerals, their quality assessment, which is especially important in selective mining and the choice of the optimal ore dressing technology. Research methodology. Для исследования электрических свойств были использованы образцы в форме кубика с ребром 0,02 м. To study the electrical properties, samples in the form of a cube with an edge of 0.02 m were used. The measurements were performed in an open system at atmospheric pressure. The electrical resistance was measured with two-electrode setup every 10 degrees in the temperature range of 20–900 ºC. The heating rate is 0.066 deg/s. Measuring instrument – E6-13 teraohmmeter with dynamic range from 10 to 1014 Ohm and relative measurement error from ±2.5 to 4% at the end of the range. The frequency dispersion of the active resistance and the dielectric loss tangent was studied at room temperature in the range of 0.01–100 kHz. The measuring device is the LCR-819 immitance meter. The technique is described in the instruction manual for the device (LCR-819 immittance meter. Operation manual. M., 2005. 26 p.). Results. Physical, physicochemical, mineralogical and petrographic methods have been used to study samples of some minerals, rocks, ores from different deposits of the Urals. Functional relationships are revealed between the electrical parameters of high-temperature electrical conductivity (activation energy E0 , the so-called electrical resistance coefficient lg R0 ), frequency characteristics of active resistance, dielectric loss tangent of the studied samples of minerals, rocks, ores with their genetic features, mineral composition and quality. The materials presented in the work are the result of many years of research by the author. Conclusions. The given results in combination with other physicochemical parameters can be used as a reliable indicator of the rapid assessment of the studied material.
Performance evaluation of buried PVC pipelines for tank irrigation: a case study of Deevanur tank
Authors: Neelmudiyon V. T. , Preethi V. , Govindarajan S.
Published: February 2023

Water is vital to life and development in all parts of the world. Since rain or other precipitation is the only source of water, it should be carefully harvested, stored, conserved and managed for the benefit of the largest number by optimizing the use of the amount available. The available water should be utilized judiciously so that the future generation is saved from deterioration stress. This study was conducted in the Deevanur tank located in Tindivanam Taluk in Tamil Nadu, India. The study was carried out in the crop calendar years from 2006–07 to 2017–18. The performance of the tank irrigation system in this study was evaluated using a Cropping Intensity indicator. This study reveals that Cropping Intensity was increased to more than 100% after rehabilitation of the tank irrigation system and is easily observed. Before rehabilitation of the tank, the average Cropping Intensity value was only 0.87. After rehabilitation of the tank, the average Cropping Intensity value increased to 1.20. The Cropping Intensity indicator is good for evaluating the modernization of the tank irrigation system.
Hydraulic investigation of stilling basins of the barrage before and after remodelling using FLOW-3D
Authors: Zaffar Muhammad Waqas , Hassan Ishtiaq
Published: February 2023

The hydraulic performance of stilling basins is affected by their size and geometry. Taunsa Barrage, Pakistan, was constructed in 1958 and remodelled in 2008. In remodelling, baffle and friction blocks were replaced by chute blocks and dentated sill. After remodelling, sounding, and probing data during 2010–2014 revealed that flexible apron in front of some bays was washed away. This study quantified hydraulic parameters such as free surface, flow depth, Froude number, roller length, velocity, hydraulic jump efficiency, and turbulent kinetic energy for stilling basins before and after remodelling using FLOW-3D. Comparing results with the literature showed that results in the old stilling basin were closer to the literature results. The results of old stilling basin showed linear trends of tailwater depths with Froude number and roller lengths. Results of the new stilling basin deviated from the literature results because relatively weak trends of tailwater depths with the Froude number and roller lengths were revealed; velocities were higher on the basin's floor; energy dissipation was less, and there was more turbulent kinetic energy on downstream. In conclusion, hydraulic studies for other discharges, tailwater levels, and turbulence models have to be conducted to analyze hydraulic issues in the new stilling basin.
Comprehensive management and regulation method of bay ecosystem based on environmental law
Authors: Lin Quanling
Published: February 2023

In order to promote the sustainable development of the gulf ecosystem, a regulation method of the gulf ecosystem based on environmental law was proposed. Taking the coastal bay area of Fujian Province as the research object, based on the analysis of the causes of ecosystem degradation, the energy loss of the area was evaluated from three aspects of climate regulation, waste treatment and interference regulation, and the index weight of integrated ecosystem management was determined to complete the evaluation of the bay ecosystem. The results show that from 2016 to 2020, pollution has increased. The proposed comprehensive management and control methods are adopted to control the pollution index of the region within 0.3, so as to maintain a stable downward trend of pollution.
Microplastics and organics – A comparative study of sorption of triclosan and malachite green onto polyethylene
Authors: Çiftçi Gökçe , Türkeli Ülkü Dide , Özen Elif Yaren , Özdemir Melek , Sanin F. Dilek , İmamoğlu İpek
Published: February 2023

This study aims to elucidate interaction of organics with microplastics in a comparative manner via the use of two model compounds (i.e., triclosan (TCS) and malachite green (MG)) having different physicochemical properties, onto polyethylene (PE). TCS, is hydrophobic with low solubility, while MG is hydrophilic with high aqueous solubility. Kinetic studies indicate faster sorption (teq = 24 h) and equilibrium studies show much higher capacity (qe = 6,921 μg/g) for TCS, when compared to those of MG (teq = 5 d, qe = 221 μg/g). While pseudo-kinetic model fits sorption of both organics to PE, equilibrium isotherms as well as the results on effect of particle size and pH indicate dissimilar sorption mechanisms. Considering pHPZC = 2, observation of favourable sorption of TCS in acidic regions and sorption being unaffected by particle size was explained by TCS sorption to be dominated by hydrophobic interactions in amorph regions of PE. Higher removal of MG was observed at lower surface charge of PE, and a clear favourable impact of surface area on MG sorptive capacity pointed to the presence of non-specific van der Waals type interactions on the surface of PE. Mechanistic evaluations presented here contribute to our understanding of interaction of MPs with organics in aquatic ecosystems.
Integration of ozonation with water treatment for pharmaceuticals removal from Arroio Diluvio in southern Brazil
Authors: Costa Letícia Reggiane de Carvalho , Féris Liliana Amaral
Published: February 2023

Pharmaceutical compounds can reach water bodies through sewage systems. The process of water treatment is insufficient for the removal of these contaminants. The ozonation has great potential to be integrated into the treatment, since it promotes the reduction of pharmaceuticals, reduces the generation of disinfection byproducts and can reduce operational costs. In this work, the integration of the ozonation process with water treatment was studied. The ozone was applied in the pre-oxidation and intermediate ozonation stages, to evaluate the dependence of different variables. Water samples were collected from Arroio Diluvio, a river of the city of Porto Alegre (Brazil). The doses of ozone were maintained between 0.5 and 1.0 mgO3 L−1 while the coagulant was between 25 and 150 mg·L−1. Pre-ozonation resulted in a removal of pharmaceuticals at pH 10.0, time of 15 min and coagulant concentration of 52.5 mgL−1. The intermediate ozonation provided a removal with pH 10.0 and a time of 5 min of bubbling. Based on the results, it was confirmed that the synergy of the ozonation process with conventional water treatment is an effective, sensitive and fast method for the removal of pharmaceuticals from the aqueous medium.
Activation of Wnt/β-Catenin signaling in EpCAMhigh/CD44+ cells endow colorectal cancer with tumor proliferation and oxaliplatin chemoresistance
Authors: Zhou Fengqiang , Qi Yanmei , Geng Zhen , Ding Baozhong , Liu Lei
Published: February 2023

Aims:

The present study investigated the exact proportion, the extent of in vitro proliferation potential, and oxaliplatin chemoresistance of EpCAMhigh/CD44+ cancer stem cells in colorectal cancer. Its underlying mechanism was also explored.

Background:

Colorectal cancer stem cells (CSC) play crucial roles in tumorigenicity and chemoresistance. Multiple studies have shown that JAK/STAT, NOTCH, and Wnt/-catenin pathways, associated with tumour recurrence and metastasis, contribute to the proliferation and maintenance of CSCs. CSCs become resistant to chemo-radiotherapies by improving DNA damage repair, changing cell cycle checkpoints, and scavenging reactive oxygen species, resulting in a bad patient prognosis.

Objective:

This work was carried out to determine the precise fraction, the degree of in vitro proliferation capability, and the level of oxaliplatin chemoresistance exhibited by EpCAMhigh/CD44+ cancer stem cells in colorectal cancer. The research was also done to investigate its underlying process.

Methods:

Fluorescence-activated cell sorting (FACS) was applied to isolate the EpCAMhigh/CD44+ populations from three human colorectal cancer cell lines (HCT116, HT29, and LoVo), and we quantified the average proportion of the EpCAMhigh/CD44+ cells in every cell lines. The comparison of their proliferation ability and the chemoresistance to oxaliplatin with the parental cells was estimated by CCK8 assay. The activated signaling pathway was tested by Western Blotting.

result:

EpCAMhigh/CD44+ subpopulation comprise about 4.98±1.24% of the total human colorectal cancer cell lines, and the EpCAMhigh/CD44+ cells exhibited a highly better proliferation ability and stronger oxaliplatin chemoresistance than the parental cells. Wnt/β-catenin signaling pathway is activated in EpCAMhigh/CD44+ HCT116 cells.

Results:

EpCAMhigh/CD44+ subpopulation comprises about 4.98±1.24% of the total human colorectal cancer cell lines, and the EpCAMhigh/CD44+ cells exhibited a highly better proliferation ability and stronger oxaliplatin chemoresistance than the parental cells. The wnt/β-catenin signaling pathway is activated in EpCAMhigh/CD44+ HCT116 cells

conclusion:

Activation of Wnt/β-Catenin signaling in EpCAMhigh/CD44+ cells endow colorectal cancer with tumor proliferation and oxaliplatin chemoresistance.

Conclusion:

Activation of Wnt/β-Catenin signaling in EpCAMhigh/CD44+ cells endow colorectal cancer with tumor proliferation and oxaliplatin chemoresistance.
WITHDRAWN: Hidrosmin Attenuates Inflammatory Response Induced by IL1β by Suppressing the Activation of NF-κB Involving Nrf2/HO1
Pathway in Human Osteoarthritis Chondrocytes
Authors: Mingchuan Yu , Xiang Chen , Yuhong Xiao , Jing Ye , Yu Liu , Di Wang , Haili Xiao , Jun Luo
Published: February 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn from the journal "Current Cancer Drug Targets"

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

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the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Comparison of the Effect of Honey, Olive, Propolis Combined Vaginal Cream With OCP in the Treatment of Functional Ovarian Cysts in Women of Reproductive Age Referring to Health Centers, Hamadan, Iran 2020-2021
Authors: Shayan Arezoo , Parsapour Hamideh , Hosseinpoor Mehrnoosh , Masoumi Seyedeh Zahra , Kazemi Farideh , Moradkhani Shirin , Hossein Oliaei Seyed Mohammad , Assareh Zeinab , Rashidi Mohammad Kazem
Published: February 2023

Background:

The prevalence of functional ovarian cysts in women is high, and choosing an appropriate, and uncomplicated treatment is necessary.

Objective:

Compare the effectiveness of honey, olive, and propolis combined vaginal cream with OCP in the treatment of functional ovarian cysts in women of reproductive age in Iran.

Methods:

This randomized clinical trial study was performed on 40 women of reproductive age referred to Hamadan health centers in 2020. Patients were randomized into two groups, A and B. Group A received oral contraception pills for two consecutive cycles from the seventh day of the menstrual cycle tablets for 21 days after the end of menstruation until the beginning of the next menstruation. Group B received honey, olive, propolis combined vaginal cream. In both groups, the treatment continued for two consecutive cycles. Data was collected through a checklist that included clinical symptoms and ultrasound results. The results were analyzed by Stata-13 and the significance level cut-off was considered less than 0.05.

Results:

Intra-group comparisons showed that there was a statistically significant (P < 0.05) decrease in cyst size after the intervention in both groups. Intergroup differences were not statistically significant (P ˃ 0.05).

Conclusion:

Honey, olive, propolis combined vaginal cream (Nika) can be effective like oral contraceptive pills in reducing the size of ovarian cysts. It can be recommended for the treatment of functional ovarian cysts.

Clinical Trial Registration Number:

IRCT20120215009014N384
Virtual Screening and Multi-targets Investigation of Novel Diazine Derivatives
as Potential Xanthine Oxidase Inhibitors Based on QSAR, Molecular
Docking, ADMET Properties, Dynamics Simulation and Network
Pharmacology
Authors: Yi Bingxiang , Sun Jiaying , Liu Yaru , Zhang Zhiping , Wang Rui , Shu Mao , Lin Zhihua
Published: February 2023

Background:

Hyperuricemia is closely related to the occurrence of gout, hypertension,
diabetes, hyperlipidemia, cardiovascular disease, kidney disease, metabolic syndrome, etc. However,
xanthine oxidase inhibitors (XOIs) can fundamentally solve the problem of excessive uric acid.
Compared to single-target drugs, multi-target drugs are not prone to adverse reactions and exert a
synergistic effect. Therefore, the discovery of new multi-target XOIs and their mechanism of therapeutic
hyperuricemia are important to overcome adverse effects and resistance to currently available
drugs.

Objective:

The purpose of this paper is to obtain novel diazine derivatives as promising multi-target
XOIs and discover the interaction mechanism for the better treatment of hyperuricemia.

Methods:

Novel multi-target XOIs diazine derivatives, and their interaction mechanism have been
obtained through QSAR, molecular docking, dynamics simulation, and network pharmacology. In
addition, ADMET properties and synthetic accessibility of novel XOIs have been considered using
ADMETLAB 2.0 and SwissADME.

Results:

24 novel diazine derivatives as potential multi-target XOIs lead compounds have been
found through virtual screening of the PubChem database. Moreover, the most notable top five compounds
are worthy of further developing as multi-target XOIs drugs. XDH, TBK1, DGAT1, MYC,
CDKN1A, PPARD, PDE6C, and EIF4E are recommended as relevant targets of therapeutic hyperuricemia.

Conclusion:

Through the combination of different methods, we have discovered five novel promising
diazine derivatives as potential multi-target XOIs drugs. Meanwhile, eight targets have been
found to be helpful in the research on therapeutic hyperuricemia. We expect this investigation will
offer clear insights into the production of efficient XOIs drugs.
The ABCB1 C3435T Polymorphism is Associated with Triglyceride Reduction
in Atorvastatin-treated Uygur Patients with Coronary Heart Disease
and Dyslipidemia: An Observational Study
Authors: Li Hongjian , Yu Luhai , Wang Tingting , Wu Jianhua , Liu Tingting , Xu Li , Feng Jie , Zhang Huilan , Shen Hao , Sun Li
Published: February 2023

Background:

The morbidity of coronary heart disease (CHD) and dyslipidemia in the Uygur
population of Xinjiang is higher than the national average. Interindividual variability of the response to
atorvastatin is a major clinical problem; generally, statins shed less impressive benefits for females than
males. Nevertheless, it is unclear whether ABCB1 genes and sex modify the efficacy of atorvastatin in
Uygur patients.

Objective:

To determine the impact of ABCB1 gene polymorphisms on the therapeutic response to
atorvastatin in a Uygur population with dyslipidemia.

Methods:

Patients with dyslipidemia were treated with 20 mg/d or 40 mg/d atorvastatin for two to six
months. TC, LDL-C, HDL-C, TG, APOB, APOE, LP(a), and APOA1 levels were measured before and
after atorvastatin administration. We performed genotyping of ABCB1 C3435T and G2677T variants using
hybridization sequencing. The association of variants between the percentage of change in TG levels
was examined using multiple linear regression analysis.

Results:

We enrolled 193 Uygur patients. Atorvastatin reduced TG, LDL-C, TC, APOB, and APOE levels
(P < 0.05), whereas LP(a) and APOA1 levels increased (P < 0.05). In multiple linear regression analysis,
baseline TG level (beta 0.204; 95% confidence interval (CI): 1.980–10.493; P = 0.004) and TT genotype
of ABCB1 C3435T (beta 0.162; 95% CI: 2.517–23.406; P = 0.023) predicted TG reduction with atorvastatin
therapy in overall patients. Baseline TG level (beta 0.346; 95% CI: 4.374 -13.34; P < 0.001) with the
TT genotype of ABCB1 C3435T (beta 0.401; 95% CI: 4.053–28.356; P = 0.021) was associated with a
significant reduction in TG levels in men. Only baseline TG level predicted TG reduction within six
months of atorvastatin therapy for females (beta 0.61; 95% CI: 3.204–20.557; P = 0.041).

Conclusions:

In patients with the ABCB1 C3435T TT genotype, atorvastatin more effectively lowered TG
than other polymorphisms. This investigation may provide insights into effective individualized therapies
for CHD and dyslipidemia in the Uygur population.
Recent Patents on Motorized Spindle Cooling Strategies
Authors: Li Weiwei , Dai Ye , Wang Gang , Wang Qinghai , Pang Jian
Published: February 2023

High-speed motorized spindle is the core component of high-speed machining machine
tools, and thermal error is the main factor affecting the machining accuracy of the motorized spindle.
Reducing thermal error has become the most important research topic in the case of motorized
spindles. The development status of the cooling strategy of the motorized spindle is explored, and
the methods to improve the cooling efficiency of the motorized spindle are discussed. Some representative
research results of the cooling strategy of motorized spindles at home and abroad are reviewed.
Based on summarizing the related research results on cooling strategies for the core components,
such as the stator, rotor and bearing of the motorized spindle, this paper analyzes the advantages
and disadvantages of various cooling strategies and their applicable working conditions,
and the future development direction of motorized spindle cooling strategies is discussed. The combination
of various channel structures and the cooling strategy of the stator outer ring of the motorized
spindle will improve the cooling efficiency of the motorized spindle, and research on the motorized
spindle core cooling will become more and more important. In addition, the cooling system
of the motorized spindle bearing, stator, and rotor can be improved at the same time, and the heating
problem of the motorized spindle can be solved.
On the problem of countering latent crime
Authors:   Rasul M. Akutaev Dagestan State University, Akutaev Rasul M. , Abdulmazharov Arthur N. ,   Arthur N. Abdulmazharov All-Russian State University of Justice (RPA of the Ministry of Justice of Russia) NorthCaucasusInstitute(branch)
Published: February 2023

The article is devoted to one of the necessary conditions for countering latent crime, predetermined by the colossal scale of latent crime to be countered. Taking into account this circumstance, theauthorsconsider it necessary to conduct a kind of revision of criminal legislation in order to exclude fromit everythingthat could be regulated by the norms of administrative legislation no less effectively than it is currentlythecase.The author's opinion is stated, according to which another solution to the problemcould be the attributionofthesecrimes (mainly of minor gravity) to the number of criminal offenses, if the inclusion of this categoryof offensesincriminal legislation receives the approval of the legislator. In this case, it is impossible to dowithout changingtheexisting categorization of crimes. It is emphasized that with all the peculiarities of the legal regulationofcrimesand offenses in terms of countering their latency, law enforcement officers should conduct anoffensivefightagainst crime and offenses, ensure consistent implementation of the inevitability of legal responsibilityfortheircommission.
The problem of distinguishing public-law and private-law relations when considering CAS disputes
Authors:   Tatiana V. Glinshchikova  Kuban State Agrarian University named after I.T. Trubilin, Glinshchikova Tatiana V. , Naryshkina Anna V. ,   Anna V. Naryshkina Kuban State Agrarian University named after I.T. Trubilin
Published: February 2023

This scientific article examines the theoretical and practical aspects of the activitiesof theInternational Court of Arbitration for Sport in Lausanne. The prerequisites and reasons for the emergenceofaninternational independent body for the resolution of disputes arising fromthe activities of subjects of professionalsports are considered. Also, the role and legal significance of the arbitration decision adoptedin2022forRussiansports organizations is noted. In the article, the authors analyzed the Decision of the International ArbitrationCourt in the case CAS 2022/A/8708 Football Union of Russia (FUR) v. Fédération InternationaledeFootballAssociation (FIFA) et al., identified "gaps" and shortcomings of the legal technique of the adoptedact. Particularattention was paid to the legal assessment of the evidence on the basis of which the Court of ArbitrationforSportissued a decision to dismiss the claim of the Russian Football Union. In addition, the unreasonablenessoftheapplication of collective responsibility is considered.
A Semantic Relatedness Model for the Automatic Cluster Analysis of Phonematic and Semantic Verbal Fluency Tasks Performed by People With Parkinson Disease: Prospective Multicenter Study (Preprint)
Authors: Hähnel Tom , Feige Tim , Kunze Julia , Epler Andrea , Frank Anika , Bendig Jonas , Schnalke Nils , Wolz Martin , Themann Peter , Falkenburger Björn
Published: February 2023

BACKGROUND

Phonematic and semantic verbal fluency tasks (VFTs) are widely used to capture cognitive deficits in people with neurodegenerative diseases. Counting the total number of words produced within a given time frame constitutes the most commonly used analysis for VFTs. The analysis of semantic and phonematic word clusters can provide additional information about frontal and temporal cognitive functions. Traditionally, clusters in the semantic VFT are identified using fixed word lists, which need to be created manually, lack standardization, and are language specific. Furthermore, it is not possible to identify semantic clusters in the phonematic VFT using this technique.

OBJECTIVE

The objective of this study was to develop a method for the automated analysis of semantically related word clusters for semantic and phonematic VFTs. Furthermore, we aimed to explore the cognitive domains captured by this analysis for people with Parkinson disease (PD).

METHODS

People with PD performed tablet-based semantic (51/85, 60%) and phonematic (69/85, 81%) VFTs. For both tasks, semantic word clusters were determined using a semantic relatedness model based on a neural network trained on the Wikipedia (Wikimedia Foundation) text corpus. The cluster characteristics derived from this model were compared with those derived from traditional evaluation methods of VFTs and a set of neuropsychological parameters.

RESULTS

For the semantic VFT, the cluster characteristics obtained through automated analyses showed good correlations with the cluster characteristics obtained through the traditional method. Cluster characteristics from automated analyses of phonematic and semantic VFTs correlated with the overall cognitive function reported by the Montreal Cognitive Assessment, executive function reported by the Frontal Assessment Battery and the Trail Making Test, and language function reported by the Boston Naming Test.

CONCLUSIONS

Our study demonstrated the feasibility of standardized automated cluster analyses of VFTs using semantic relatedness models. These models do not require manually creating and updating categorized word lists and, therefore, can be easily and objectively implemented in different languages, potentially allowing comparison of results across different languages. Furthermore, this method provides information about semantic clusters in phonematic VFTs, which cannot be obtained from traditional methods. Hence, this method could provide easily accessible digital biomarkers for executive and language functions in people with PD.
“El papelito que me salvó la vida”: Objetos portadores de memoria y la Guerra de Malvinas
Authors: Avila Sebastian Leonardo , Landa Carlos
Published: February 2023

El presente trabajo se propone explorar y analizar la interacción entre objetos -entendidos como portadores de memorias, sentires y afectos- y testimonios, observando la capacidad de esa relación para recuperar memorias sobre la guerra. A partir de cuatro entrevistas a veteranos, se analizará la intercorporalidad generada entre objetos -presentes o evocados- y sujetos -con sus gestos y sentidos corporales- al momento de construcción y despliegue de sus testimonios: ¿Cómo se relacionan las memorias de los veteranos de la Guerra de Malvinas con los objetos que sobrevivieron al conflicto?, ¿Qué tipo de memorias despierta el recordar en base a dichos objetos?, ¿Qué relación se establece entre estas memorias, los sentidos y los cuerpos de los veteranos?, ¿Todos los objetos son portadores de memorias? Algunos de estos interrogantes nos guiarán a través de las palabras, los gestos, las emociones y los objetos e imágenes en los que todavía perdura la experiencia de una guerra que quiso ser olvidada.
Identidad guerrera tlaxcalteca del Posclásico tardío
Authors: López Corral Aurelio
Published: February 2023

El objetivo de este trabajo es presentar los resultados del análisis contextual y osteológico de tres entierros primarios encontrados en Tepeticpac, Tlaxcallan, cuyas ofrendas remiten a ciertos atributos de la identidad guerrera tlaxcalteca del Posclásico tardío (1250/1300-1519 d.C). Comparamos la evidencia arqueológica de los entierros con las descripciones históricas locales que hablan de un estrato social conocido como yaotequihuaque o “capitanes de guerra”. Los yaotequihuaque fueron particularmente importantes dentro de la jerarquía de Tlaxcallan durante el Posclásico tardío ya que eran el resultado de la movilidad socioeconómica promovida por méritos de guerra. Este trabajo resulta relevante para la arqueología de la región poblano-tlaxcalteca, puesto que indaga sobre la identidad guerrera de los Tlaxcaltecas y si sólo se aplicaba a aquellos que participaron en la guerra, o si es posible argumentar que dicha identidad fuera adoptada como metáfora aplicada a individuos que no estuvieron involucrados directamente en eventos bélicos. También abordamos la posible identificación de individuos prominentes dentro de la jerarquía de Tlaxcallan y su relación con procesos de movilidad socioeconómica promovida por méritos de guerra dentro de una sociedad basada en el gobierno colectivo.
Del mito a la conservación del armadillo en la región otomí-mazahua
Authors: Ávila Nájera Dulce María , Gómez Sánchez David , Paulino Escamilla Sergio
Published: February 2023

Los pueblos otomí-mazahua que habitan en el Estado de México mantienen un vínculo con su entorno natural que va más allá de la división entre humanos y animales; esta relación interespecie nos permite entender cómo en el pensamiento indígena, la vida silvestre en este caso representada por el armadillo tiene una conexión muy particular reconocida en la tradición oral mítica y ritual que permite entender la importancia de la conservación del armadillo en un habitad en el que interactúan humanos y animales. A través de una investigación etnográfica y trabajos bibliográficos se realizó la investigación con el objetivo de entender cuáles son los vínculos entre lo animal y lo humano que permitan la conservación de la especie desde la perspectiva otomí-mazahua, para dar respuesta a la interrogante nos basamos en el precepto fundamental de analizar las cuestiones míticas, rituales, usos y biología del armadillo para poder encontrar elementos para su conservación. El armadillo es una de las especies con mayor presión de caza, es usado como alimento, medicina y ornamento, artesanal, entre otros usos, forma parte activa de las tradiciones orales en la comunidad mazahua-otomi. Dado que los animales forman parte activa de la cosmovisión de los pueblos, esto permite consolidar estrategias de conservación junto con los enfoques ecológicos y biológicos para proteger a especie en peligro de extinción.
Linajes y señores en El Tajín del periodo Epiclásico. Una tumba en el Conjunto Arquitectónico del Edificio de las Columnas
Authors: Pascual Soto Arturo , Barba Pingarrón Luis , Cerritos Flores René
Published: February 2023

El artículo se hace cargo de la sociedad del período Epiclásico en El Tajín, Veracruz, y de las investigaciones arqueológicas que llevaron al descubrimiento de una tumba perteneciente a un tardío gobernante de la ciudad. Se trata del primer monumento funerario hallado hasta ahora en este sitio de la llanura del Golfo de México y por ello su extraordinaria importancia. Al hallarla vacía, decidimos acompañar estas investigaciones con una serie de estudios que buscaron determinar la existencia de residuos organicos en el piso de la tumba y a partir de ellos se obtuvo de ADN antiguo.
"Estrechando lazos. Perspectivas multidiciplinarias sobre el Estado de México" Clementina Battock y Raymundo C. Martínez García (coords.)
Authors: Pérez Castro Ana Bella
Published: February 2023

Es una obra colectiva que tuvo su origen a partir de dos actividades: el homenaje a la Dra. Yoko Sugiura Yamamoto por sus aportes al Valle de Toluca, lo que llevaría a la segunda actividad: la inauguración del seminario permanente “Miradas intedciplinarias sobre el estado de México, estudios perspectivas y propuestas.”

La obra consta de tres partes, la primera,La perspectiva arqueológica,enmarca los trabajos desde la perspectiva arqueológica y se integra por los textos de la Dra. Yoko Sugiura “Arqueología en el Alto Lerma, estudio de la vida lacustre”, el de Gustavo Jaimes Vences “Viviendo entre ollas, cazuelas y cajetes: uso de vasijas cerámicas en el sitio arqueológico de Santa Cruz Atizapán desde el Clásico tardío hasta el Epiclásico”, el tercero es de Rubén Nieto y Gustavo Jaimes Vences “Estudiando lo pasado se aprende lo nuevo”: experiencias y anécdotas de una vida dedicada a la Arqueología Homenaje a la Dra. Yoko Sugiura”
Web Application for Emotion-Based Music Player using Streamlit
Authors: Padmaja Dr. J Naga , Kanth Amula Vijay , Reddy P Vamshidhar , Rao B Abhinay
Published: February 2023

Abstract: Music is a language that doesn’t speak in particular words, it speaks in emotions. Music has certain qualities or properties that impact our feelings. We've numerous music recommendation systems that recommend music based on the previous search history, previous listening history, or ratings provided by users. Our project is all about developing a recommendation system that recommends music based on the user’s current mood. This approach is more effective than the existing ones and eases user’s work of first searching and creating a specific playlist. A user’s emotion or mood can be identified by his/her facial expressions. These expressions can be deduced from the live feed via the system’s camera. Machine Learning come up with various methods and techniques through which human emotions can be detected. Support Vector Machine (SVM) algorithm is used to develop this system. The SVM is used as a classifier to classify different emotional states such as happy, sad, etc. The facial feature displacements in the live feed are used as input to the SVM classifier. Based on the output of the SVM classifier, the user is redirected to a corresponding playlist. Streamlit Framework is used to build this web application. It helps us to create beautiful web apps for data science and machine learning in less time.
desigualdades de género en la innovación inclusiva de la producción trucha-arcoíris, Estado de México
Authors: Sepúlveda Hernández Sara , Vizcarra Bordi Ivonne , Moctezuma Pérez Sergio , García Mondragón David , Gómez Demetrio William
Published: February 2023

Este artículo es una reflexión desde la economía feminista de ruptura sobre las implicaciones del enfoque de la innovación inclusiva y en las relaciones de género al interior de las unidades de producción de trucha arcoíris (Oncorhychus mykiss) (UPTA) en el Estado de México. Se centra en la mirada masculina institucionalizada de productores sobre el trabajo de las mujeres. Desde este punto de vista se analizan las contradicciones de la innovación inclusiva en campos desigualdades de género que afectan directamente a las mujeres. A través de entrevistas semiestructuradas realizadas a productores, funcionarios institucionales y académicos y observación directa, se respondieron las interrogantes: ¿Cómo construyen los hombres el valor social del trabajo de las mujeres en las UPTA? ¿Cuál es la participación de las mujeres en los procesos técnico – prácticos para desarrollar innovaciones? La heteronormatividad interiorizada en los procesos de aprendizaje técnicos y en la toma de decisiones económico – productivas, las mujeres pierden relevancia como protagonistas creativas de la innovación que podrían traducirse en mejorar la eficiencia de las UPTA. La ideología patriarcal que domina las relaciones de producción de género en actividades acuícolas, heteronormaliza el papel de las mujeres en una categoría subordinada, quedando excluidas de los proyectos de innovación. Se concluye sobre la necesidad de tener un nuevo enfoque de la innovación inclusiva feminista al poner como eje la sostenibilidad de la vida.