bluuebunny/crossref_metadata_2025 huggingface dataset:
Stat3 Inhibitors TTI-101 and SH5-07 Suppress Bladder Cancer Cell Survival In 3D Tumor Models
Authors: Singh Surya Pratap , Pathuri Gopal , Asch Adam S , Rao Chinthalapally V. , Madka Venkateshwar
Published: July 2024

Bladder cancer (BC) is one of the most lethal genitourinary malignancies owing to its propensity for recurrence and poor survival. The biochemical pathway, signal transducer and activator of transcription 3 (STAT3), has gained significance as a molecular pathway that promotes proliferation, invasion, and chemoresistance. In this study, we explored the targeting of STAT3 with TTI-101 and SH5-07 in bladder cancer (BCa) and elucidated the mechanisms in three-dimensional (3D) spheroid and tumoroid models. We optimized the growth of spheroids from human, rat, and mouse BCa cell lines (J82, NBT-II, and MB49, respectively), and tumoroids from BBN (N-butyl-N-(4-hydroxybutyl)-nitrosamine) induced rat bladder tumors. Cell viability was assessed using MTT and trypan blue assays. ATP production, ROS production, and calcium AM (CA)/EtBr staining were used to measure the spheroid and organoid inhibition and mitochondrial function. Western blot analysis was performed to evaluate the pharmacodynamic markers involved in cell proliferation, apoptosis, cancer stem cells (CSCs), and STAT3 signaling in BCa. We found that targeting STAT3 (using TTI-101 and SH5-07) significantly reduced the proliferation of BCa spheroids, and tumoroids, which was accompanied by decreased expression of pSTAT3, Cyclin D1, and PCNA. Our data also demonstrated that treatment with STAT3 inhibitors induced ROS production and cell death in BCa spheroids and organoids. STAT3 inhibition induced cell death was associated with the activation of caspase 3/7 and PARP cleavage. Moreover, TTI-101 and SH5-07 targets cancer stem cells by downregulating the expression of CD44 and CD133 in 3D models. This study provides the first evidence for the prevention of bladder cancer with small-molecule inhibitors TTI101 and SH5-07 via suppression of CSCs and STAT3 signaling.
Rethinking Public Participation in Forest Policies: A Literature Review of Participatory Techniques
Authors: De Meo Isabella , Paletto Alessandro , Baldessari Sofia
Published: July 2024

Recently, the concept of participatory democracy developed in the early 1970s has come back into fashion to revitalize the public involvement in political decision-making processes. Public par-ticipation in forest policy has been fully conceptualized by the scientific community in the late 1990s and early 2000s, but in many contexts the practical application remains unfulfilled. The aim of this study is to identify and analyze the participatory techniques used in literature to increase knowledge and facilitate its transferability into forest policies and strategies. A literature review was carried out to offer an overview of the participatory techniques adopted in the deci-sion-making process. At the end of literature review, 25 participatory techniques were identified based on over 2,000 publications. Afterwards, the participatory techniques were assessed using seven indicators (degree of participation, type and number of participants, time scale, cost, po-tential influence on policy). The results showed that the type of actors involved in the participa-tory technique is a key variable for the complexity and usefulness of the process, while the number of participants influences how information is disseminated. The Principal Component Analysis highlighted that the participatory techniques can be divided in three groups: the first group includes those techniques with a high degree of participation and a contextual high po-tential influence on policies, the second one includes techniques with a costs in terms of re-sources, while the third one consists of those with a large number of participants and reduced time requirements.
Valley‐Spin‐Polarization of MoS2 Monolayer Induced by Ferromagnetic Order in an Antiferromagnet
Authors: Chan Chun-Wen , Hsieh Chia-Yun , Chan Fang-Mei , Huang Pin-Jia , Yang and Chao-Yao
Published: July 2024

Transition metal dichalcogenides (TMDs) monolayers exhibit unique valleytronics properties due to the dependency of the coupled valley and spin state at the hexagonal corner of the first Brillouin zone. Precisely controlling valley spin-polarization via manipulating the electron population enables its application in valley-based memory or quantum technologies. This study uncovered the uncompensated spins of the antiferromagnetic oxide (NiO) serving as the ferromagnetic (FM) order to induce valley spin-polarization in molybdenum disulfide (MoS₂) monolayers via the magnetic proximity effect (MPE). A spin-resolved photoluminescence spectroscopy (SR-PL) was employed to observe MoS₂, where the spin-polarized trions appear to be responsible for the MPE, leading to a valley magnetism. Results indicate that local FM order from the uncompensated surface of NiO could successfully induce significant valley spin-polarization in MoS₂ with the depolarization temperature approximately at 100 K, which is relatively high compared to related literature. This study reveals new perspectives and potential of AFM materials in the field of exchange-coupled van der Waals heterostructures.
Combine Usage Possibilities of Entomopathogenic Nematodes with Insecticides against Mediterranean Corn Borer Sesamia nonagrioides (Lefebvre)
Authors: Erdem Esengül
Published: July 2024

The Mediterranean Corn Borer (MCB), Sesamia nonagrioides, poses a significant threat to maize crops, necessitating effective pest management strategies. This study investigates the compatibi-lity of two entomopathogenic nematode (EPN) isolates, Steinernema feltiae KV6 and Heterorhabditis bacteriophora EO7, with four registered insecticides for MCB control: deltamethrin, flubendiamide, spinetoram, and betacyfluthrin. The impact of these insecticides on EPN mortality, infectivity, and reproduction was assessed. Results indicate that deltamethrin exhibits the lowest toxicity to EPNs, with mortality rates of 1.3% for S. feltiae and 0.63% for H. bacteriophora at field dose (FD) after 24 hours, and 4.63% and 1.96% respectively after 48 hours. In contrast, spinetoram and flubendiamide showed higher toxicity, with mortality rates of 38.04% and 14.17% for S. feltiae at FD after 48 hours. The infectivity assays demonstrated that deltamethrin-treated EPNs caused up to 100% mortality in MCB larvae, while the reproduction capacity varied significantly between the EPN species and insecticides. H. bacteriophora exhibited higher progeny production, especially in the presence of Deltamethrin (87,900 IJs/larva). The findings suggest that integrating EPNs with selective insec-ticides like deltamethrin can enhance pest control efficacy and support sustainable agricultural practices. This study provides valuable insights for developing integrated pest management (IPM) strategies aimed at mitigating MCB infestations in maize while minimizing environmental im-pacts.
Age-Related Memory Decline Is Accelerated by Pinealectomy in Young Adult and Middle-Aged Rats via BDNF / ERK / CREB Signalling in the Hippocampus
Authors: Tchekalarova Jana , Atanasova Dimitrinka , Krushovlieva Desislava , Barbutska Darina , Atanasova Milena , Rashev Pavel , Nenchovska Zlatina , Mourdjeva Milena , Koeva Yvetta
Published: July 2024

Memory decline is considered a normal part of aging, while the relationship between melatonin deficiency and cognitive function is complex and not fully understood. The present study investigated the role of melatonin deficiency functioning as a hormone at different ages on working and short-term recognition and spatial memory in rats. An age-related decline in memory function was tested in the Y-maze, the object recognition test, and the radial arm maze. Aging was associated with reduced expression of brain-derived neurotrophic factor (BDNF) throughout the hippocampus, whereas pinealectomy exacerbated this process specifically in the CA3 region of 3- and 14-month-old rats. The region-specific reduced expression of the extracellular signal-regulated kinase (ERK)1/2 and pERK1/2 was observed in young adult rats with pinealectomy. However, in middle-aged rats, the expression of these signaling molecules was either downregulated or upregulated in different hippocampal regions. The reduced ratio of pCREB/CREB in the frontal cortex and hippocampus was associated with memory impairment in young adult and middle-aged melatonin-deficient rats, whereas old rats were unaffected. Our study provides insights into the molecular pathways involved in age-related memory changes associated with melatonin deficiency, highlighting the importance of the BDNF / ERK1/2 / CREB pathway in the hippocampus and suggesting a critical period for intervention.
Application of Bayesian Statistics in Analyzing and Predicting Carburizing-Induced Dimensional Changes in Torsion Bars
Authors: Sun Guojin , Xu Linqian , Wang Qi
Published: July 2024

This paper explores the feasibility of applying Bayesian statistical methods to study the distortion patterns induced by carburizing heat treatment. By establishing posterior and predictive distribution models for torsion bar dimensions, we aim to accurately understand and predict the expansion behavior, thus enhancing control over carburizing-induced dimensional changes. Bayesian methods allow for the integration of prior knowledge and real-time data, providing a more comprehensive understanding of the distortion phenomena. This approach not only improves the precision of dimensional predictions but also contributes to optimizing the overall manufacturing process, ensuring that the torsion bars meet the rigorous standards required for high-performance applications in demanding industrial environments.
Gender Disparities in Urban Design: A Review of the Impact of Urban Design on Shaping Women's Social Challenges
Authors: KhalatbariLimaki Armita
Published: July 2024

Urban environments play a crucial role in shaping the lived experiences of women, yet traditional urban design practices often neglect the diverse needs and identities of women, perpetuating social barriers and gender inequalities. This review paper seeks to explore the existing research on how urban design influences women's social challenges in cities. By synthesizing literature from urban planning, architecture, gender studies, and sociology, this review provides a comprehensive overview of the impact of urban design on women's experiences and opportunities in urban spaces. The review highlights gender disparities in urban design, inclusivity in urban planning, and the need for gender-sensitive approaches to address these disparities. Key scholars, including Susan S. Fainstein, Leslie Kern, Sharon Zukin, Daphne Spain, and Vandana Shiva, have contributed significantly to understanding gender disparities in urban spaces and advocating for more inclusive and equitable urban environments. The discussion emphasizes the importance of community engagement, participatory planning processes, and an intersectional lens in urban design to ensure that women's voices and needs are effectively incorporated into decision-making processes. Future research directions include exploring the role of technology, smart city initiatives, and addressing the impacts of gentrification and urban redevelopment on women's access to housing and resources. By advancing research on gender equity in city planning, we can work towards creating more inclusive, equitable, and sustainable urban environments that benefit all residents.
Farmers’ Perceptions on Crop Diversification to Enhance the Adaptive Capacity under Climate Change: The Case of Pistachio in French Mediterranean Region
Authors: Teixeira da Silva Siqueira Tiago , Debolini Marta
Published: July 2024

Climate change is an important threat to orchard production at Mediterranean basin. Diversification seems to be implemented at a farm level as an important strategy to face these challenges. This paper aims to analyse farmer’s perceptions on crop diversification as a way to enhance farm’s adaptive capacity in a context of current and future climate changes impacts. Our case study is focused in orchards growers from French department of Vaucluse recently diversifying their activities through pistachio (Pistacia vera L.). We did in-depth semi-structured farmers’ interviews in 2021. The results show that diversification is supposed to enhance 3 main components of farms adaptative capacity: (1) strengthening robustness through improvement of buffering capacities to climate impacts (trough robust and adapted plants), economic uncertainties (by exploring local/niche markets) and labour scarcity (by lowering workforce requirements and mechanization); (2) Learning by experimenting, monitoring and exchanging with pairs and advisors (3) Cope with change related with societal demands and helps to increase personal satisfaction. Finally, promote farm’s diversification can contribute to enhance farm’s adaptive capacity under climate change impacts.
Hazardous Chemicals Detection and Classification Through Millimeter Wave and Machine Learning
Authors: Ilagan Lorena C. , Dadios Elmer P.
Published: July 2024

This paper demonstrates the effectiveness of integrating computational intelligence to enhance the reliability of millimeter wave technology as a detection device for hazardous chemicals. The research explores the use of millimeter wave as an efficient and dependable alternative technology for chemical detection with the aid of machine learning to further improve its reliability and accuracy. This advancement is crucial in enabling security agencies, and authorities to remotely identify hazardous chemicals, minimizing risks to human lives and properties. The millimeter wave relies on natural non-ionizing radiation, which is of low power and considered safe for human exposure. The millimeter wave region used in this study is 77–81 GHz that offers short-pulse transmission capabilities, producing a wide spectrum of frequencies. These short pulses serve as the source for collecting the broadband spectral identity of chemicals, and the subsequent detection is post-processed with machine learning to increase the level of accuracy. The result of this study shows that by using computational intelligence models such as decision tree, k-nearest neighbor, support vector machine, and random forest, enhances the overall device reliability, and achieves higher detection accuracy based on the received reflected power. This result is comparable to an X-ray system device.
Automatic Classification of Sleep-Wake States of Newborns Using Only Body and Face Videos
Authors: Ito Yuki , Morita Kento , Matsumoto Asami , Shinkoda Harumi , Wakabayashi Tetsushi
Published: July 2024

The premature newborn receives specialized medical care in the neonatal intensive care unit (NICU), where various medical devices emit excessive light and sound stimulation, and those prolonged exposures to stimuli may cause stress and hinder the development of the newborn’s nervous system. The formation of their biological clock or circadian rhythm, influenced by light and sound, is crucial for establishing sleep patterns. Therefore, it is essential to investigate how the NICU environment affects a newborn’s sleep quality and rhythms. Brazelton’s classification criteria measure the sleep-wake state of newborns, but the visual classification is time-consuming. Therefore, we propose a method to reduce the burden by automatically classifying the sleep-wake state of newborns from video images. We focused on videos of whole-body and face-only videos of newborns and classified them into five states according to Brazelton’s classification criteria. In this paper, we propose and compare methods of classifying whole-body and face-only videos separately using a three-dimensional convolutional neural network (3D CNN) and combining the two results obtained from whole-body and face-only videos with time-series smoothing. Experiments using 16 videos of 8 newborn subjects showed that the highest accuracy of 0.611 and kappa score of 0.623 were achieved by weighting the time-series smoothed results from whole-body and face-only videos by the output probabilities from the 3D CNN. This result indicated that the time-series smoothing and combining the results based on probabilities is effective.
Digital Economy, Green Innovation and Urban-Rural Income Gap—Analysis Based on Prefecture-Level City Panel Data of China
Authors: Liu Chengkun , Yan Mengyu , Zhang Minghong
Published: July 2024

Coordinating the relationship between the digital economy, green innovation, and the urban-rural income gap is conducive to promoting common prosperity in high-quality development. This study aims to show that, in the short term, the development of the digital economy will promote the level of green innovation, which, in turn, will promote the development of the digital economy, but will also widen the urban-rural income gap. The study uses panel data of 273 prefecture-level cities from 2011 to 2019, and adopts the panel vector error correction model for quantitative analysis, combined with the theoretical analysis of the long- and short-term causal relationship among the digital economy, green innovation, and urban-rural income gap. The results reveal that, in the long term, the digital economy, green innovation, and urban-rural income gap demonstrate a double-circular causality that is positively promoting each other. The robustness test validates the conclusions. Therefore, while promoting the development of the digital economy and green innovation, the government should control the urban-rural income gap within a reasonable range, to provide theoretical and practical support for promoting the sustainable development of China’s economy and realizing the goal of common prosperity.
Nonlinear Risk Spillover Path Between China’s Carbon Market, China’s New Energy Market, and the International Crude Oil Futures Market
Authors: Yao Yanyun , Tang Zifeng , Niu Guiqian , Cai Shangzhen
Published: July 2024

The carbon market was established to reduce carbon dioxide emissions. The traditional fossil energy market, new energy market, and carbon market have interrelated effects such as substitution, demand, and production inhibition, which can potentially lead to risk transmission. This study examines the nonlinear volatility correlation between China’s carbon market, China’s new energy market, and the international crude oil futures market. Seven submarkets within these three markets are selected for analysis. By measuring volatility risk through the conditional heteroscedasticity of returns, the analysis of nonlinear Granger causality networks reveals that, from a nonlinear perspective, risk primarily spills over through the paths of “International crude oil futures market → China’s carbon market” and “International crude oil futures market → China’s new energy market → China’s carbon market.” China’s carbon market serves as a recipient of risk, with minimal spillover effects. Therefore, further optimization is needed for the framework of China’s carbon market to enhance its asset allocation function and promote its spillover influence. Investors in China’s carbon market should consider both linear and nonlinear risks from China’s new energy market and the international crude oil futures market, and take appropriate measures to facilitate the sustainable growth of Chinese enterprises.
Impact of Financial Distress on the Capital Expenditure of Local Enterprises
Authors: Sun Jie , Sun Mingyang , Sun Ya-ni
Published: July 2024

This study defines financially distressed enterprises based on stock delisting risk warnings and uses the annual data of A-share listed companies on the Shanghai and Shenzhen stock exchanges from 2008 to 2021 to examine the impact and mechanism of financial distress on the capital expenditures of non-distressed enterprises in the same city. The results indicate that if financially distressed enterprises exist within a city, the capital expenditure of non-distressed enterprises within the same city will subsequently decrease. The conclusions hold after multiple robustness and endogeneity tests. Mechanism tests show that financially distressed enterprises reduce the operating performance and cash flow of non-distressed enterprises in the same city through business performance contagion, thereby reducing their intrinsic motivation for capital expenditure. However, financial distress enhances creditors’ credit risk perceptions of non-distressed enterprises in the same city through signal transmission effects, prompting creditors to tighten credit contracts or directly intervene in corporate capital expenditure decisions, thus suppressing corporate capital expenditure. Heterogeneity tests indicate that the smaller the asset size of non-distressed enterprises, the larger the scale of financially distressed enterprises relative to non-distressed enterprises in the same city, or the more severe the agency problem of non-distressed enterprises or degree of financial distress, the more significant the negative externality of financial distress on the capital expenditures of local enterprises. The economic consequences test shows that the reduction effect of financial distress on the capital expenditure of non-distressed enterprises in the same city ultimately improves their capital expenditure efficiency.
Imitating with Sequential Masks: Alleviating Causal Confusion in Autonomous Driving
Authors: Zhang Huanghui , Zheng Zhi
Published: July 2024

Imitation learning which uses only expert demonstrations is suitable for safety-crucial tasks, such as autonomous driving. However, causal confusion is a problem in imitation learning where, with more features offered, an agent may perform even worse. Hence, we aim to augment agents’ imitation ability in driving scenarios under sequential setting, using a novel method we proposed: sequential masking imitation learning (SEMI). Inspired by the idea of Granger causality, we improve the imitator’s performance through a random masking operation on the encoded features in a sequential setting. With this design, the imitator is forced to focus on critical features, leading to a robust model. We demonstrated that this method can alleviate causal confusion in driving simulations by deploying it the CARLA simulator and comparing it with other methods. The experimental results showed that SEMI can effectively reduce confusion during autonomous driving.
Robust Detection for Demagnetization Fault in the Permanent-Magnet Synchronous Motor Using Improved Sliding-Mode Observer
Authors: Zhang Miaoying , Cheng Xiang , Xiao Fan , Zhang Faming
Published: July 2024

This paper investigates a robust detection for demagnetization fault in the permanent-magnet synchronous motor (PMSM). A proportional-integral fading sliding-mode observer (PIFSMO) is proposed, which can solve the problem of PMSM performance degradation caused by the permanent-magnet demagnetization and resistance disturbance increase during long-term operation. A PMSM demagnetization model is established, and an improved PIFSMO is proposed to detect the demagnetization flux linkage. A fading integral term is added to the traditional sliding-mode observer, which can suppress the offset in the resistance disturbance estimation caused by transients, thereby achieving direct estimation of the resistance disturbance and the slowly varying resistance disturbance (e.g., ḋ≠0) in particular. Simulation and experimental results demonstrate the feasibility and effectiveness of the proposal.
Fall Detection Based on Graph Neural Networks with Variable Time Windows
Authors: Wei Jiawei , Li Junjie , Liu Yuqing , Ma Hongbin
Published: July 2024

The precise detection of falls is essential for promptly providing first aid to individuals who are at risk of accidental injury. Presently, the predominant approach for detecting falls is through inertial measurement unit (IMU) sensors, which can capture the real-time motion of an object. However, it is difficult for the current approach to face the challenges in attaining the anticipated performance in real-world applications, owing to the diverse nature of human behavior. To tackle this concern, a fall detection approach that uses a graph convolutional neural network (GCN) with variable time windows (T-GCN) is introduced. The proposed method uses well-designed graph topologies to effectively mitigate the impact of inconsistent data dimensions. Meanwhile, variable time windows are designed to capture keyframe data and to enhance their validity. To evaluate the effectiveness of the T-GCN method, a dataset Dhard containing 12 suspected falls and four real falls is built. The experimental results show that the T-GCN method achieves an accuracy of 91.3% and a precision of 92.5%, surpassing the average accuracy and precision of conventional fall detection methods.
Design of an Intelligent Control System for Compound Directional Drilling in Underground Coal Mines
Authors: Li Wangnian , Wu Min , Chen Shipeng , Mu Lingfeng , Lu Chengda , Chen Luefeng
Published: July 2024

The compound directional drilling process, including slip and rotation, is the key to realizing long-hole drilling in coal mines. First, a compound directional drilling process control scheme is proposed to realize intelligent control of the directional drilling process. An intelligent drilling process optimization method was designed to improve drilling efficiency. A robust controller for the drilling rate based on gain scheduling was designed to achieve stable control of the drilling rate during sliding deflection drilling. A robust controller based on hybrid sensitivity was designed to achieve stable control of the drilling rate during rotary inclined stabilization drilling. The results of this study can provide a theoretical basis for realizing the intelligent optimization and control of compound directional drilling in coal mines.
Osmanlı Devleti'nde Gayr-i Avârız Sınıflar ve Mütekâid Tahrirleri
Authors: Karazeybek Mustafa
Published: July 2024

Osmanlı tarihinin 17. ve 18. yüzyıllarının aydınlatılmasında önemli kaynaklardan biri avârız defterleridir. Avârız defterlerinde kişiler genel olarak avârız hanesine bağlı olanlar ve gayr-i avârızlar olarak iki ana gurupta kaydedilmiştir. Avârız tahrirleri, mufassal ve icmal avârız defterleri ve avârız haneleri hakkında pek çok çalışma yapılmıştır. Ancak gayr-i avârızlar ile mütekâid tahrirleri şu ana kadar müstakil bir çalışmaya konu olmamıştır. Bu tahrirlerin ne zaman başladığı ve hangi dönemlerde yapıldığına ilişkin de şu ana kadar ortaya konmuş net bir bilgi yoktur. Avârız defterlerinde, avârız hanesine tabi olanlar tek bir sınıf olarak kaydedilmiştir. Gayr-i avârızların ise kazâlara göre değişebilen farklı sınıfların bir araya gelmesiyle oluştuğu görülmektedir. Gayr-i avârızların içerisinde en geniş sınıfı mütekâidler oluşturmasından dolayı gayr-i avârızlar genellikle "mütekâʻid" ismiyle anılmışlardır. Bu çalışmada gayr-i avârızlar konu alınarak yeni bir tahrir türü olarak "mufassal mütekâid tahrirleri" ele alınmıştır. Konu büyük ölçüde arşiv kaynakları kullanılarak tetkik edilmiştir. Örnek olarak, tespit edilen dört mütekâid tahrir defterinin de tanıtımı yapılmıştır.
Delayed Achilles Tendon Rupture at 17 Years of Age After Treatment of Clubfoot with Ponseti Method
Authors: Wako Masanori , Ichikawa Jiro , Fujimaki Taro , Hagino Tetsuo , Haro Hirotaka
Published: July 2024

Case:

Traumatic pediatric Achilles ruptures are rare, and few cases have been reported among patients with a history of Achilles tenotomy. A 17-year-old boy with a history of Achilles tenotomies for congenital clubfoot as an infant presented with acute midsubstance Achilles tendon rupture of the right leg. The gastrocnemius fascia was dissected to allow for approximation of the ruptured Achilles tendon segments. Furthermore, the plantaris tendon was harvested and sutured around the Achilles tendon-rupture site to improve strength.

Conclusions:

Patients with a history of clubfoot and chronic Achilles tendon pain should be alerted to the risk of Achilles tendon rupture.
Realidad aumentada, impulso de la creatividad y las multi-inteligencias en la universidad
Authors: Martín-Ramallal Pablo , Bertola-Garbellini Andrea , Polo-Serrano David
Published: July 2024

La Universidad cubre tres demandas desde el triángulo del conocimiento: educación, investigación y transferencia del conocimiento. En este sentido, existen factores transversales que unifican la institución, la creatividad y la inteligencia. Los docentes disponen de una variedad de instrumentos sin precedentes para potenciarlas, siendo cada día más valoradas, por lo que se ven fomentadas específicamente en los diversos planes de estudio. Una propuesta prometedora para promover estas competencias es la realidad aumentada. El artículo trata de explicar cómo dicha narrativa comienza a ser un recurso que mejora el pensamiento divergente en el espacio universitario. La innovación que justifica la investigación se ofrece desde la convergencia con los estudios de Gardner, ya que aplicar la taxonomía de las inteligencias múltiples se encuentra en comunión con el pensamiento crítico y el desarrollo personalizado de las capacidades de los/las alumnos/as. La metodología se basa en un proceso de teorización y en un cuestionario Likert al que han sido sometidos estudiantes universitarios con conocimientos en realidades extendidas, presentando diversas apps inmersivas observadas estas desde las multi-inteligencias como estudios de caso. Como conclusión, la realidad aumentada en la Universidad es percibida entre el estudiantado como un relato que impulsa la creatividad y las multi-inteligencias personalizadamente
n el avance de las mujeres árabes en Israel
Authors: Mozuyan Nassar , Hidalgo-Ariza Mª Dolores
Published: July 2024

This study investigates the role of technology integration in educational frameworks on empowering Arab women in Israeli society, focusing on their participation in the high-tech sector. It tests two hypotheses: that technology integration boosts Arab Israeli women's interest in STEM and high-tech careers, and that it enhances their societal and economic empowerment.
Despite the success of Israel's high-tech industry and advancements in education, Arab women remain underrepresented in this sector. The research utilizes a structured questionnaire to assess digital literacy's impact on Arab Israeli women's career aspirations in high-tech.
The findings suggest that integrating technology into education can significantly increase Arab women's interest in STEM fields, supporting their greater involvement in the high-tech industry. The study underscores the importance of continued technological integration in education to promote diversity and inclusion in the high-tech sector. However, limitations include a regional focus and a quantitative approach, indicating the need for further research to fully understand the empowerment of Arab women in the Israeli high-tech industry.
Keywords: Technology Integration, Arab Israeli Women, High-Tech Sector, STEM Education
Temporal Variation of Nitrate Concentrations in Karst Spring in the Western Part of the Gunungsewu Karst Area, Java Island, Indonesia
Authors: Cahyadi Ahmad , Riyanto Indra Agus
Published: July 2024

أصبح وجود النترات في الماء مصدر قلق للعديد من علماء البيئة لأنه أدى إلى انخفاض جودة المياه المستخدمة لتلبية احتياجات الناس من المياه النظيفة. من المتوقع أن توفر دراسة التغير الزمني للنترات في تدفق المياه فهمًا كاملاً للعوامل المؤثرة التي يجب إدارتها للتحكم في تركيز النترات في الماء. تهدف هذه الدراسة إلى تحليل التغيرات الزمنية في تركيز النترات في نبع جونتور، أحد الينابيع في منطقة جونونجسيو كارست والذي يلعب دورًا في توفير المياه النظيفة. تشمل البيانات المستخدمة في هذا البحث بيانات عن تركيز النترات في مياه الينابيع، وهطول الأمطار، وتصريف الينابيع. تم إجراء أخذ العينات كل أسبوعين من فبراير 2018 إلى مارس 2019 لفهم التباين الزمني في تركيزات النترات. تم الحصول على بيانات التصريف وهطول الأمطار من التسجيل التلقائي خلال نفس فترة أخذ عينات المياه لتحليل النترات. وتظهر النتيجة أن تركيز النترات على مدار العام في نبع جونتور لا يتجاوز معايير الجودة. ترجع جودة المياه الجيدة إلى عملية الترشيح الطبيعية التي لا تزال تسير بشكل جيد بسبب انخفاض مستوى الكارستات الذي لا تزال تهيمن عليه تدفقات الشقوق. بالإضافة إلى ذلك، وجد هذا البحث أن الاختلاف الأكثر تأثيرًا في تركيز النترات في تدفق الربيع في جونتور سبرينج هو نمط المحاصيل في المنطقة.
Topological Indices and QSPR/QSAR Analysis of Some Drugs Being Investigated for the Treatment of Alzheimer's Disease Patients
Authors: H Mohammed Yasin H , M Suresh , Bayati Jalal Hatem Hussein
Published: July 2024

يعد تحليل العلاقات الكمية بين البنية والممتلكات/النشاط (QSPR/QSAR) أمرًا بالغ الأهمية لفهم خصائص المركبات المرتبطة بالمخدرات، خاصة في علاج مرض الزهايمر. في هذه الدراسة، هدفنا هو استخدام أساليب مبتكرة بما في ذلك استخدام المؤشرات الطوبولوجية -درجة و-  درجة ، المستمدة من نظرية الرسم البياني، لتقييم الخصائص والخصائص الفيزيائية والكيميائية لخمسة أدوية لمرض الزهايمر: تاكرين، دونيبيزيل، ريفيستيجمين، جالانتامين و والهوبرزين أ . تقدم هذه المؤشرات الطوبولوجية طريقة جديدة لالتقاط المعلومات الهيكلية الجزيئية الأساسية، مما يقلل من عدد الواصفات مع تعزيز ارتباطها بالخصائص الجزيئية المتنوعة. ومن خلال الحسابات الشاملة لهذه المؤشرات، هدفنا هو توضيح الخصائص الجزيئية المعقدة لأدوية مرض الزهايمر. علاوة على ذلك، أجرينا تحليلات QSPR وQSAR لربط المؤشرات الطوبولوجية المحسوبة بالخصائص الفيزيائية والكيميائية المختلفة للأدوية. في حين أن الأساليب المبتكرة المستخدمة في دراستنا توفر رؤى قيمة. لا تساهم النتائج التي توصلنا إليها في تعزيز فهمنا لخصائص أدوية مرض الزهايمر فحسب، بل تحمل أيضًا آثارًا على تطوير الأدوية وتحسينها في إدارة مرض الزهايمر. ومن خلال تعزيز معرفتنا بخصائص هذه المركبات، فإن هدفنا هو معالجة الطبيعة المتعددة العوامل لمرض الزهايمر وتحسين التدخلات العلاجية.
Synthesis, Characterization, and Thermal Studying of VO(II), Cu(II), Zn (II), Cd(II), and Au (III) Complexes with Azo Dye and Evaluation as Antioxidants
Authors: Malek Fadhel Areeg , Ali Salih Al-Hamdani Abbas , Al Zoubi Wail
Published: July 2024

حضرت معقدات كل من الفنادايل, الخارصين, النحاس والكادميوم بتكافؤهم الثنائي والذهب بتكافؤه الثلاثي بأستخدام صبغة ازوجديدة (6،4،2-ثلاثي هيدروكسي-3-((3-هيدروكسي فنيل) ثنائي زينيل ) فنيل ) ايثان-1-اون المحضرة من ملح الديازونيوم مع ٦,٤,٢- ثلاثي هيدروكسي اسيتوفينون بعد عزل (E)-1-(2,4,6-trihydroxy-3-((3-hydroxyphenyl)diazenyl)phenyl)ethan-1-one تم تشخيصها بواسطة الطرق الطيفية المتاحة  والتقنيات التشخيصية لكل من التحليل الدقيق للعناصرواطياف كل من الكتلة ,الرنين النووي البروتوني والكاربوني ,الاشعة فوق البنفسجية ,الاشعة تحت الحمراءومنحنى التحلل الحراري الوزني والمسعر التفاضلي والمعقدات شملت التقنيات هذه فضلا عن تحديد نسبة الفلز وتحديد محتوى الكلور والحساسية المغناطيسية والتوصيلية المولارية. أعطت النتائج أن الليكاند ايوني (سالب) رباعي السن مرة عند تناسقه مع النحاس والخارصين والكادميوم عن طريق ذرة الاوكسجين الفينولية و ذرة الاوكسجين الكاربونيلية وذرة نتروجين الازو , بينما كان ثلاثي السن عند التناسق مع الذهب الثلاثي من خلال ذرة الاوكسجين الفينولية وذرة نتروجين الازو حيث اعطى الذهب شكل مربع مستوي متعادل بينما الخارصين والكادميوم ثماني السطوح متعادل حاوي على جزيئتين ماء متناسقة واعطى النحاس شكل رباعي السطوح متعادل اما الفنادايل فاعطى شكلا ثنائي الهرم المثلثي متعادل. ثم تم تحديد قابلية هذه المركبات المحضرة كمضادات اكسدة من خلال كبحها للجذور الحرة باستعمال مادة DPPH كجذر حر وفيتامين C كمرجع لتحديد قيمة IC50التي اعطت النتائج(Au-complex >H4L>Ascorbic acid > Zn-complex> Cu-complex> Cd-complex>V-complex)
Synthesis, Identification, and Biological Evaluation of new coumarin-pyrazoline Derivatives as Anti-oxidant Agents
Authors: Yusuf Khalaf Wafaa , Abdulredha Raheem Leaqaa , Sabah Elias Youssef Rita
Published: July 2024

تم تهجين مركب الكومارين مع جزيء غير متجانس يحتوي على النيتروجين يعرف باسم بيرازولين وذلك لزيادة نشاطه البيولوجي، وأظهر نطاقا واسعا من النشاط. تضمنت الدراسة تحضير مركب جديد بطريقة التكثيف، وتم تشخيصها وأثبات الهياكل التركيبية للمركبات المحضرة بمطيافية الاشعة تحت الحمراء، بروتون ن م ر ومطيافية كاربون-13 بالاضافة الى مطيافية الكتلة (, FT-IR 1HNMR، MS, 13CNMR,   (والتي اثبت من خلالهما تكون حلقة البيرلزوين من خلال ظهور بروتونات مجموعة المثيلين في ثوابت ازدواج مختلفة.  من ناحية اخرى بروتون   C11’ ,يتكيف مع زاويتين متجاورتين مختلفتين لبروتوني مجموعة المثيلين , فعليه ان ثابت ازدواج البروتونات المتجاورة مع بعضها البعض اعلى منها لبروتونات المجاورة لبعضها البعض ويمكن للزاوية الثنائية الاتجاه بين البروتونات ترتبط بعلاقة كاربلس مع ثابت ازدواج البروتونات المتجاورة. كما تمت دراسة النشاط الحيوي للمركبات المحضرة باستخدام مبدأ مقايسة ABTS•+ والذي اعتمد على توليد كروموفور الاخضر/ المزرق من خلال التفاعل بين ABTS وبيرسلفات البوتاسيوم عند حوالي 734 نانومتر، حيث أظهرت النتائج أن مشتقات الكومارين- بيرازولين تتميز بنشاط مضاد للأكسدة عالي يتفوق على نشاط حامض الأسكوربيك، وخاصة مشتق ثنائي مثيل أمين .
Damage recovery of epoxy coating reinforced carbon nanoparticle / polypropylene fibers hybrid filler
Authors: Al-Kawaz Ammar Emad , Musafir Mustafa Abdul Hussein , Al-Kawaz Yasir A. , Ibrahim Manar K.
Published: July 2024

ركز البحث على تقييم تأثير دمج جزيئات الكربون النانوية (CNP) وألياف البولي بروبيلين في مركبات الإيبوكسي على خواصها الميكانيكية في مجال علم المواد. أظهرت التجربة أن زيادة النسبة الوزنية لألياف البولي بروبيلين أدت إلى زيادة معامل المرونة في متراكبات الايبوكسي. وعلى العكس من ذلك، فإن دمج أسود الكربون، بنسب وزن متفاوتة، لم يسفر عن زيادة مقابلة في معامل المرونة للمركبات الناتجة. على العكس من ذلك، لوحظ تحسن ملحوظ في معامل المرونه عند استخدام نسب مختلفة من الحشو الهجين، المشار إليه بـ CNP/PP. علاوة على ذلك، أشار تحليل الصلابة، والتي تم قياسها باستخدام مقياس Shore D، إلى تحسن طفيف مع تصاعد تركيز أسود الكربون، في حين لوحظ انخفاض طفيف مع زيادة نسبة وزن ألياف البولي بروبيلين. سلط البحث أيضًا الضوء على سلوكيات التعافي المتميزة في العينات المعززة بالإيبوكسي، حيث أظهرت عينات أسود الكربون تفضيلًا للشفاء على طول محور العرض، و عينات البولي بروبيلين تفضل الشفاء على طول محور العمق. في سياق المركبات الهجينة، تبين أن سلوك الاسترداد كان موزعًا بشكل أكثر توازناً، بما في ذلك أبعاد العمق والعرض.
Pengembangan LKPD POE Berbasis Scientific Literacy untuk Meningkatkan Kemampuan Menulis Ilmiah Peserta Didik
Authors: Rofiah Anisaatur , Faizah Ulinnuha Nur
Published: July 2024

Pembelajaran IPA dengan menggunakan keterampilan Abad 21 mengharuskan siswa terlibat aktif saat pembelajaran. Pembelajaran IPA pasti erat hubungannya dengan  penyelidikan ilmiah, hipotesis, serta kepenulisan dari hasil penyelidikan tersebut. Tujuan dari penelitian ini adalah untuk mengetahui (1) validitas (2) kepraktisan  (3) efektivitas. Adapun penelitian ini dirancang dengan metode R&D dengan model pengembangan ADDIE. Pengambilan data dilakukan dengan lembar validasi ahli, lembar angket kepraktisan, dan soal tes. Adapun lokasi penelitian di SMP Negeri 1 Siman. Teknik pengambilan sampel dilakukan dengan menggunakan purposive sampling. Sampel berjumlah 59 peserta didik kelas IX B sebagai kelas kontrol dan IX C sebagai kelas eksperimen. Data yang dihasilkan kemudian di analisis menggunakan uji validasi, uji kepraktisan,  tes kemampuan menulis ilmiah, uji two tailed, uji  one tailed, uji ancova, dan uji N-gain. Berdasarkan penelitian didapatkan hasil bahwa LKPD POE berbasis scientific literacy dinyatakan (1) sangat valid mendapatkan persentase  94.5%  (2) sangat praktis dengan persentase 100% (3) efektif melalui uji two tailed dengan hasil 0.00<0.005 H0 ditolak maka terdapat perbedaan kemampuan menulis kelas eksperimen dan kontrol.  Uji one tailed dengan hasil 0.00<0.05 H0 ditolak maka terdapat peningkatan kemampuan menulis ilmiah siswa. Uji ancova mendapatkan hasil 0.00<0.05 maka dinyatakan terdapat perbedaan yang signifikan yang mempengaruhi hasil pre test dan post test kelas eksperimen dan kontrol.  N-gain, pada uji N-gain mendapatkan hasil 61.26 dengan kategori sedang.
Efektivitas Model Pembelajaran Think Pair Share dengan Pendekatan Education for Sustainability Development (ESD) untuk Meningkatkan Kemampuan Kolaborasi Peserta Didik
Authors: Priandini Astrida Bela , Aristiawan Aristiawan
Published: July 2024

Kurikulum 2013 memiliki tujuan salah satunya yaitu agar peserta didik mempunyai kompetensi dan menumbuhkan jiwa kolaborasi. Kemampuan kolaborasi merupakan kemampuan berpartisipasi dan saling bekerjasama untuk mencapai tujuan bersama. Tujuan penelitian ini untuk mengetahui keterlaksanaan pembelajaran, aktivitas peserta didik dan pengaruh model pembelajaran Think Pair Share dengan pendekatan Education for Sustainability Development (ESD) untuk meningkatkan kemampuan kolaborasi peserta didik kelas VIII di MTsN 6 Ponorogo. Penelitian ini menggunakan metode kuantitatif quasi experimental design group. Pengambilan data melalui observasi dengan instrumen lembar observasi. Partisipasi pada penelitian ini yaitu peserta didik kelas VIII MTsN 6 Ponorogo yang dipilih secara random sampling. Hasil penelitian diketahui bahwa keterlaksanaan pembelajaran mengalami peningkatan disetiap pertemuannya dan diperoleh rata-rata 89% dengan kategori sangat baik. Aktivitas peserta didik juga mengalami peningkatan diperoleh rata-rata 68% dengan kategori baik. Kemampuan kolaborasi berdasarkan rata-rata menunjukkan bahwa kemampuan kolaborasi peserta didik yang menggunakan model pembelajaran Think Pair Share dengan pendekatan Education for Sustainability Development (ESD) tidak sama dengan kemampuan kolaborasi peserta didik yang menggunakan model pembelajaran konvensional (kontrol). Dengan perolehan hasil rata-rata yang tidak sama maka dapat dikatakan bahwa model pembelajaran Think Paair Share dengan pendekatan Education for Sustainability Development (ESD) berpengaruh terhadap kemampuan kolaborasi peserta didik kelas VIII MTsN 6 Ponorogo.
Literasi Informasi di Era Pandemi Covid-19: Studi Fenomenologi Calon Guru IPA
Authors: Sayekti Titah , Zulfah Zulfah
Published: July 2024

Informasi yang beredar pada masa pandemi sangat bervariasi dengan tingkat validitas yang berbeda-beda. Tujuan dari penelitian ini adalah untuk melihat fenomena literasi informasi yang terjadi pada masa ini. Fenomenologi dipilih sebagai metode penelitian dengan populasi penelitian adalah mahasiswa program IPA di provinsi Jawa Timur sedangkan sampelnya adalah mahasiswa pendidikan IPA dari 5 kabupaten dan 1 kota di Jawa Timur. Data dikumpulkan melalui wawancara dan pengisian formulir survei. Analisis data dilakukan dengan metode analisis Miles dan Huberman yang terdiri dari reduksi dan penyajian data berdasarkan masing-masing literasi informasi dan penarikan kesimpulan. Hasil analisis data menggambarkan bahwa responden cukup baik dalam menentukan sifat dan cakupan informasi yang dibutuhkan. Hal ini ditunjukkan dengan 79% sampel menyatakan pentingnya memilih topik dalam mengakses informasi mengenai covid 19. Upaya mengakses informasi yang dibutuhkan secara efektif dan efisien juga cukup baik, mengingat 58% sampel memilih situs resmi pemerintah yang sesuai. lebih meyakinkan dalam penyajian data. Sementara itu, proses evaluasi kritis terhadap informasi dan sumbernya juga telah dilakukan yang ditunjukkan dengan 93% sampel menyatakan perlunya klarifikasi dan diskusi atas informasi yang diperoleh. Pencapaian tujuan akses informasi cukup baik dengan adanya upaya sebagian besar responden dalam menentukan tujuan akses informasi pada awal proses. Dengan adanya penetapan tujuan maka arah pencarian akan lebih terfokus sehingga 75% sampel mengungkapkan tercapainya tujuan. Pemahaman yang baik terhadap aspek hukum, ekonomi, dan sosial terkait penggunaan informasi terlihat pada pemilahan informasi yang akan disebarluaskan. Sebanyak 137 sampel menyatakan bahwa validitas informasi merupakan kriteria penting agar informasi layak untuk diteruskan. Secara garis besar responden sudah berupaya menerapkan literasi informasi meskipun tentunya masih ada hal yang perlu diperkuat.
Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy
Authors: bezzerides Vassilios , Yoshinaga Daisuke , Feng Rui , Prondzynski Maksymilian , Shani Kevin , Tharani Yashasvi , Mayourian Joshua , Joseph Milosh , Walker David , Bortolin Raul , Carreon Chrystalle , Boss Bridget , Upton Shelia , Parker Kevin , Pu William
Published: July 2024

N-terminal-acetyltransferases including NAA10 catalyze N-terminal acetylation (Nt-acetylation), an evolutionarily conserved co-translational modification. Little is known about the role of Nt-acetylation in cardiac homeostasis. To gain insights, we studied a novel NAA10 variant (p.R4S) segregating with QT-prolongation, cardiomyopathy and developmental delay in a large kindred. Here we show that the NAA10-R4S mutation reduced enzymatic activity, decreased expression levels of NAA10/NAA15 proteins, and destabilized the enzymatic complex NatA. In NAA10R4S/Y-iPSC-CMs, dysregulation of the late sodium and slow rectifying potassium currents caused severe repolarization abnormalities, consistent with clinical QT prolongation. Engineered heart tissues generated from NAA10R4S/Y-iPSC-CMs had significantly decreased contractile force and sarcomeric disorganization, consistent with the pedigree’s cardiomyopathic phenotype. We identified small molecule and genetic therapies that normalized the phenotype of NAA10R4S/Y-iPSC-CMs. Our study defines novel roles of Nt-acetylation in cardiac regulation and delineates mechanisms underlying QT prolongation, arrhythmia, and cardiomyopathy caused by NAA10 dysfunction.
Vaccine Effectiveness Of Bivalent HPV Vaccination Against Genital HPV Of A Catch-Up Campaign And 12 Years Routine Vaccination For Girls-Only: A Biennial Repeated Cross-Sectional Study
Authors: Kusters Johannes MA , Loeff Maarten F Schim , Benthem Birgit HB , King Audrey J , Melker Hester E , Heijman Titia , Heijne Janneke CM
Published: July 2024

Background
The Netherlands is one of few countries worldwide which has used the bivalent HPV vaccine for girls-only for over a decade. This allows assessment of vaccine effectiveness (VE) against female genital HPV DNA-positivity of this vaccine in an observational post-licensing real-world setting. Additionally, it is unclear whether catch-up vaccination campaigns result in similar VE as routine vaccination. Therefore, type-specific and grouped VE were assessed and compared for women who had been eligible for catch-up vaccination at 13–16 years with those who had been eligible for routine vaccination at 12 years.
Methods
PASSYON is a Dutch biennial repeated cross-sectional (2011-21) study among sexual health clinic clients aged 16–24 years old. Women provided self-collected vaginal samples, questionnaires on demographics and sexual behaviour were administered, and women self-reported HPV vaccination status. Samples were analysed using a PCR-based assay (SPF10-LiPA25). Type-specific and grouped VE estimates, adjusted with propensity score stratification, were assessed against genital positivity for 14 HPV-types. VE for targeted and non-targeted genotypes were compared between women who had been eligible for the catch-up and those who had been eligible for routine vaccination.
Results
The study included 4,488 female participants who had been eligible for HPV vaccination and provided genital swabs (1,561 eligible for catch-up, 2,927 for routine vaccination). Very high VE against genital HPV-16 and HPV-18 was observed (resp. 93.5% and 89.5%) and significant cross-protection against six other genotypes (HPV-31/33/35/45/52/58), varying from 18.0% (HPV-52) to 79.6% (HPV-45). VE estimates were comparable between women who had been eligible for the catch-up campaign and those eligible for routine vaccination: VE HPV-16/18: 92.2% (95%CI: 87.9–94.9) vs. 91.8% (95%CI: 86.0-95.2).
Conclusions
In real-world settings, the VE of bivalent vaccine is high against targeted genotypes, with cross-protection against 6 other genotypes. Catch-up campaigns up to age 16 years can be as effective as routine vaccination at age 12. This may inform countries considering catch-up campaigns when introducing or extending the use of HPV vaccination within their national immunisation programmes.