bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydroxypropyl Cellulose/Pluronic-Based Composite Hydrogels as Biodegradable Mucoadhesive Scaffolds for Tissue Engineering
Authors: Filip Daniela , Macocinschi Doina , Zaltariov Mirela-Fernanda , Ciubotaru Bianca-Iulia , Bargan Alexandra , Varganici Cristian-Dragos , Vasiliu Ana-Lavinia , Peptanariu Dragos , Balan-Porcarasu Mihaela , Timofte-Zorila Mihaela-Madalina
Published: August 2022

Recently, the development of new materials with the desired characteristics for functional tissue engineering, ensuring tissue architecture and supporting cellular growth, has gained significant attention. Hydrogels, which possess similar properties to natural cellular matrixes, being able to repair or replace biological tissues and support the healing process through cellular proliferation and viability, are a challenge when designing tissue scaffolds. This paper provides new insights into hydrogel-based polymeric blends (hydroxypropyl cellulose/Pluronic F68), aiming to evaluate the contributions of both components in the development of new tissue scaffolds. In order to study the interactions within the hydrogel blends, FTIR and 1HNMR spectroscopies were used. The porosity and the behavior in moisture medium were highlighted by SEM and DVS analyses. The biodegradability of the hydrogel blends was studied in a simulated biological medium. The hydrogel composition was determinant for the scaffold behavior: the HPC component was found to have a great influence on the BET and GAB areas, on the monolayer values estimated from sorption–desorption isotherms and on mucoadhesivity on small intestine mucosa, while the Pluronic F68 component improved the thermal stability. All blends were also found to have good mechanical strength and increased biocompatibility on the NHDF cell line. Based on their particular compositions and increased mucoadhesivity on small intestine mucosa, these polymeric blends could be effective in the repair or recovery of damaged cell membranes (due to the contribution of Pluronic F68) or in control drug-delivery intestinal formulations.
Effects of Sorbitan Monostearate and Stearyl Alcohol on the Physicochemical Parameters of Sunflower-Wax-Based Oleogels
Authors: Bharti Deepti , Kim Doman , Banerjee Indranil , Rousseau Derick , Pal Kunal
Published: August 2022

A rising health concern with saturated fatty acids allowed researchers to look into the science of replacing these fats with unsaturated fatty acids. Oleogelation is a technique to structure edible oil using gelators. The present study looked for the effect of solid emulsifiers; namely, sorbitan monostearate (SP) and stearyl alcohol (SA), on the physicochemical parameters of oleogels. All the oleogels were formulated using 5% sunflower wax (SW) in sunflower oil (SO). The formulated oleogels displayed irregular-shaped wax crystals on their surface. The bright-field and polarized microscopy showed the fiber/needle network of wax crystals. Formulations consisting of 10 mg (0.05% w/w) of both the emulsifiers (SA10 and SP10) in 20 g of oleogels displayed the appearance of a dense wax crystal network. The SP and SA underwent co-crystallization with wax molecules, which enhanced crystal growth and increased the density and size of the wax crystals. The XRD and FTIR studies suggested the presence of a similar β’ polymorph to that of the triacylglycerols’ arrangement. The incorporation of SA and SP in wax crystal packing might have resulted in a lower crystallization rate in SA10 and SP10. Evaluation of the thermal properties of oleogels through DSC showed better gel recurrence of high melting enthalpy. These formulations also displayed a sustained release of curcumin. Despite the variations in several properties (e.g., microstructures, crystallite size, thermal properties, and nutrient release), the emulsifiers did not affect the mechanical properties of the oleogel. The meager amounts of both the emulsifiers were able to modulate the nutrient release from the oleogels without affecting their mechanical properties in comparison to the control sample.
Predisposition to Myocardial Infarction Influenced by Interleukin 13 Gene Polymorphisms: A Case-Control Study
Authors: Hosseini Seyyed Fatemeh , Khashei Varnamkhasti Khalil , Naeimi Raziyeh , Naeimi Leila , Naeimi Sirous
Published: August 2022

Background: Additional inflammatory responses and subsequent damage—arising from enhance transcriptional activity or forming the more active protein due to existence of polymorphic sites in the pro-inflammatory cytokines gene loci—give rise to myocardial infarction susceptibility. Objectives: The aim of our study was to explore whether two interleukin-13 gene polymorphisms (−1512A/C and +2044G/A) could serve as underpins genetic susceptibility of myocardial infarction. Methods: The Iranian population that belong to the Parsis ethnic group was involved in the present study. A total 250 patients with definite myocardial infarction—meeting hypertension, hypercholesterolemia, hyperglycemia, and coronary artery disease requirements—were recruited from the Shiraz urban hospitals. 250 age- and sex-matched healthy individuals without a history of cardiovascular disease and heart disease related risk factors constituted the control group. PCR-restriction fragment length polymorphism technique applied to genotyping at −1512A/C and +2044G/A loci. Hardy–Weinberg equilibrium test was performed (combined cases and controls). The differences of the genotype frequencies in cases and controls were analyzed using a chi-square test. Logistic regression analysis was performed to assess the association between the genotypes and most important risk factors for myocardial infarction. All statistical analyses were performed in SPSS Version 22.0. p-values below 0.05 were hailed as statistically significant. Results: Deviation from Hardy–Weinberg equilibrium was not significant in the −1512A/C locus. Statistically significant difference between our study groups was found in genotype frequency of the −1512A/C. This variant was found in associated with myocardial infarction risk factors. The +2044G/A polymorphism was not in Hardy–Weinberg equilibrium and no significant difference observed in the distribution of +2044G/A genotype frequency among cases and controls. However, further analysis revealed that this genotype associated with an increased susceptibility to myocardial infarction risk factors. Conclusions: The presence of interleukin-13 −1512A/C and +2044G/A gene polymorphisms underpin myocardial infarction predisposition in the ethnic Parsis of the Iranian population.
Metabolomic Profiling Reveals Common Metabolic Alterations in Plasma of Patients with Toxoplasma Infection and Schizophrenia
Authors: Osman Emelia , Mohammad Zahariluddin Anis Safirah , Sharip Shalisah , Md Idris Zulkarnain , Tan Jen Kit
Published: August 2022

Toxoplasma gondii is an opportunistic protozoan parasite known to affect the human brain. The infection has been associated with an increased incidence of schizophrenia; however, the link between the two conditions remains unclear. This study aimed to compare the plasma metabolome of schizophrenia and non-schizophrenia subjects with or without Toxoplasma infection. Untargeted metabolomic profiling was carried out by liquid chromatography-mass spectrometry. Elevation of the α-hydroxyglutaric acid level and reduced adenosine monophosphate, inosine, hypoxanthine and xanthine were found in the subjects with either toxoplasmosis or schizophrenia alone. These results suggest that purine catabolism is a common metabolic alteration in Toxoplasma infection and schizophrenia. The roles of these metabolites on the pathogenesis of schizophrenia in relation to Toxoplasma infection warrant further studies.
When a Synonymous Variant Is Nonsynonymous
Authors: Vihinen Mauno
Published: August 2022

Term synonymous variation is widely used, but frequently in a wrong or misleading meaning and context. Twenty three point eight % of possible nucleotide substitution types in the universal genetic code are for synonymous amino acid changes, but when these variants have a phenotype and functional effect, they are very seldom synonymous. Such variants may manifest changes at DNA, RNA and/or protein levels. Large numbers of variations are erroneously annotated as synonymous, which causes problems e.g., in clinical genetics and diagnosis of diseases. To facilitate precise communication, novel systematics and nomenclature are introduced for variants that when looking only at the genetic code seem like synonymous, but which have phenotypes. A new term, unsense variant is defined as a substitution in the mRNA coding region that affects gene expression and protein production without introducing a stop codon in the variation site. Such variants are common and need to be correctly annotated. Proper naming and annotation are important also to increase awareness of these variants and their consequences.
Genomic Assessment of Cancer Susceptibility in the Threatened Catalina Island Fox (Urocyon littoralis catalinae)
Authors: Hendricks Sarah A. , King Julie L. , Duncan Calvin L. , Vickers Winston , Hohenlohe Paul A. , Davis Brian W.
Published: August 2022

Small effective population sizes raise the probability of extinction by increasing the frequency of potentially deleterious alleles and reducing fitness. However, the extent to which cancers play a role in the fitness reduction of genetically depauperate wildlife populations is unknown. Santa Catalina island foxes (Urocyon littoralis catalinae) sampled in 2007–2008 have a high prevalence of ceruminous gland tumors, which was not detected in the population prior to a recent bottleneck caused by a canine distemper epidemic. The disease appears to be associated with inflammation from chronic ear mite (Otodectes) infections and secondary elevated levels of Staphyloccus pseudointermedius bacterial infections. However, no other environmental factors to date have been found to be associated with elevated cancer risk in this population. Here, we used whole genome sequencing of the case and control individuals from two islands to identify candidate loci associated with cancer based on genetic divergence, nucleotide diversity, allele frequency spectrum, and runs of homozygosity. We identified several candidate loci based on genomic signatures and putative gene functions, suggesting that cancer susceptibility in this population may be polygenic. Due to the efforts of a recovery program and weak fitness effects of late-onset disease, the population size has increased, which may allow selection to be more effective in removing these presumably slightly deleterious alleles. Long-term monitoring of the disease alleles, as well as overall genetic diversity, will provide crucial information for the long-term persistence of this threatened population.
Clinical Items for Geriatric Patients with Post-Stroke at Discharge or Transfer after Rehabilitation Therapy in a Chronic-Phase Hospital: A Retrospective Pilot Study
Authors: Koumo Masatoshi , Goda Akio , Maki Yoshinori , Yokoyama Kouta , Yamamoto Tetsuya , Hosokawa Tsumugi , Ishibashi Ryota , Katsura Junichi , Yanagibashi Ken
Published: August 2022

Clinical factors related to destination after rehabilitation therapy for geriatric patients with post-stroke in chronic-phase hospitals have not been elucidated. This study analyzed the clinical characteristics of geriatric patients with post-stroke at discharge/transfer after rehabilitation therapy in a chronic-phase hospital. Fifty-three patients (20 men, 33 women; mean age 81.36 ± 8.14 years) were recruited (the period analyzed: October 2013–March 2020). Clinical data were statistically analyzed among patients discharged to homes or facilities for older adults or transferred to another hospital. In addition, we analyzed the clinical items at discharge and transfer after rehabilitation therapy using a decision tree analysis. Twelve patients were discharged, eighteen were discharged to facilities for older adults, and twenty-three were transferred to another hospital. There were significant differences in the modified Rankin Scale, admission dates, functional independence measure (FIM) score, and Barthel Index score in the three groups (p < 0.05). Patients with motor subtotal functional independence scores of ≥14 (chronologically improved ≥5) after rehabilitation therapy for <291 days were more likely to be discharged home. Patients in a chronic-phase hospital who improved within a limited period were discharged to their homes, whereas those who were bedridden tended to be transferred to another hospital.
Tools for Assessing Knowledge of Back Health in Adolescents: A Systematic Review Protocol
Authors: Fiaschi Ramos Adriana Cristina , Ferreira Silva Regina Márcia , Bizinotto Thailyne , Teixeira de Rezende Leonardo Mateus , Miñana-Signes Vicente , Monfort-Pañego Manuel , Noll Priscilla Rayanne e Silva , Noll Matias
Published: August 2022

Back pain is common in adolescents as a result of their typical daily activities. There is a critical need for developing instruments that can assess the adolescents’ knowledge of proper posture, because adequate postural habits are essential for preventing back pain and facilitating physical well-being. Unfortunately, there is insufficient understanding about appropriate back health in the general public, even though this knowledge is decisive in the development of physical skills and attainment of health literacy. Furthermore, relevant substantive literature is scarce. Therefore, the proposed systematic review aims to identify instruments that are used for assessing knowledge of back health in adolescents. Relevant search terms and descriptors will be combined, and searches will be carried out in a uniform sequence within the PubMed, Embase, CINAHL, and Cochrane Library databases. Eligible articles must present data on the assessment of the adolescents’ knowledge of back health and describe the applied instrumentation. Articles will be selected by two reviewers independently; all disagreements will be resolved by a third reviewer. Mendeley and the Rayyan software will be used for the systematic review, and the checklist proposed by Brink and Louw will be used to verify the methodological quality of the included studies. Our findings may confirm the relevance of constructing and validating back health instruments for use in Brazil and other countries.
Morphological and Mechanical Properties of Book Cellulose-Based Paper (XXth Century) Treated with Hydroxyapatite Nanoparticles
Authors: Ion Rodica-Mariana , Grigorescu Ramona Marina , Iancu Lorena , David Madalina Elena , Cirstoiu Adriana , Paraschiv Georgiana Iulia , Geba Maria
Published: August 2022

Paper aging and protection processes play an essential function in the preservation of library collections and archives. In this study, some physical-mechanical properties of paper samples from XXth century books (private collections), such as pH acidity, tensile strength, and modulus of elasticity, as well as optical properties, such as absolute change in yellowness, were examined before and after treating them with hydroxyapatite nanoparticles (HAp). Accelerated light aging was also evaluated and discussed. The treatment with HAp nanoparticles increased the paper’s pH to slightly alkaline values (approximately pH 8). Washing and treating the paper improved its mechanical properties compared to untreated paper; the tear length increased by 35% and the modulus of elasticity increased by 56%. That the treated and aged samples are more elastic than the original samples demonstrates that HAp nanoparticles consolidated the cellulose fibers. Additionally, particle morphology, size, composition and size distribution were assessed via image analysis using scanning electron microscopy (SEM-EDX), atomic force microscopy (AFM), and the ImageJ processing program.
Nurses’ Knowledge and Attitudes towards Biosimilar Medicines as Part of Evidence-Based Nursing Practice—International Pilot Study within the Project Biosimilars Nurses Guide Version 2.0
Authors: Friganović Adriano , Mędrzycka-Dąbrowska Wioletta , Krupa Sabina , Oomen Ber , Decock Nico , Stievano Alessandro
Published: August 2022

Introduction: The increasing availability of biosimilars can increase patient access to these drugs and reduce the economic burden. Nurses play a key role in the education, administration, pharmacovigilance and management of the side effects of biosimilars. The aim of this study was to assess the knowledge and attitudes of nurses towards biosimilar drugs in different countries. Methods: An international cross-sectional study was conducted from November 2021 to February 2022. The survey was carried out using Computer-Assisted Web Interview (CAWI), sent by the CAWI panel via the website. Results: The results showed that nurses with a greater level of education felt most knowledgeable about biosimilars (χ2 = 105.813, df = 2, p < 0.001). One-third of nurses with a doctorate and a second degree said biosimilars are used in their workplace (χ2 = 48.169, df = 4, p < 0.001); most nurses with a second degree said that they had never heard of biosimilars (41%). Doctorate-level nurses thought knowledge is the key factor to increasing biosimilar uptake (97%). Conclusions: Nurses are not knowledgeable about biosimilars. Most would like to participate in training on biosimilars. This is a very important topic, because biosimilars are constantly evolving in medicine.
Mechanisms of Sports Concussion in Taekwondo: A Systematic Video Analysis of Seven Cases
Authors: Ha Sunghe , Kim Min Jin , Jeong Hee Seong , Lee Inje , Lee Sae Yong
Published: August 2022

Sports-related traumatic brain injuries are the most common injury in adolescents and young adults due to recurrent concussion experiences and head shock. Therefore, this study was designed to describe player characteristics and situational factors associated with concussions in the World Taekwondo Championships using systematic video analysis. Athlete injury data were collected using a web-based injury surveillance system at the World Taekwondo Championships organized by World Taekwondo from 2017 to 2019. Seven video footage were independently analyzed by four analysts using a modified Heads-Up Checklist. Descriptive statistical analysis was used. The incidence of concussion was 3.21 per 1000 games. Most players with concussions were shorter than their opponents, and most concussions were caused by a roundhouse kick on the front of the face. Regarding the acceleration direction of the head after the impact, transverse and multiplane directions were the most common. Most players with a concussion have used a closed stance and did not use blocking techniques during the defense. The rate of concussions caused by penalties was 42.9%. Based on our findings, no other injury mechanisms, except for direct blows to the head, were observed. Therefore, education on the risk and symptoms of concussion, the appropriate management and blocking techniques should be emphasized in TKD-S to reduce incidence of concussion.
Empowering Green Development: How Social Media Interaction Influences Environmental Information Disclosure of High-Polluting Firms
Authors: Deng Wei , Shao Jing
Published: August 2022

While social media has become increasingly prevalent in recent years, few studies have examined the role of social media in regulating the environmental information disclosure (EID) of high-polluting enterprises. Using a sample of 2, 211 A-share listed firms in China from 2010 to 2019, this study empirically tests the relationship between firm–investor social media interactions and the EID of high-polluting firms. The results show that social media interaction not only relieves information asymmetry in the capital market, but also triggers market and regulatory pressure for management, ultimately contributing to high-quality EID. The results are robust to a series of alternative estimation approaches and alternative measurements of core variables. Moreover, we found that the positive effect of social media interaction on EID is stronger for enterprises that receive a high level of analyst coverage and for state-owned enterprises (SOEs), but weaker for enterprises whose CEO holds a chairman position (i.e., CEO duality). In addition, further testing shows that social media interaction promotes hard EID to a larger extent than soft information, and the promotion effect is more pronounced for environment-related posts. This study deepens our understanding of how social media supplements formal regulations in the supervision of corporate EID behavior and offers important practical implications for prompting enterprises to achieve high-quality green development.
A Novel Credible Carbon Footprint Traceability System for Low Carbon Economy Using Blockchain Technology
Authors: Ju Chunhua , Shen Zhonghua , Bao Fuguang , Weng Pengtong , Xu Yihang , Xu Chonghuan
Published: August 2022

To achieve the goal of carbon neutrality, many countries have established regional carbon emission trading markets and tried to build a low-carbon economic system. At present, the implementation of carbon emission trading and low-carbon economic systems faces many challenges such as manipulation, corruption, opacity, lack of trust, and lack of data tracking means. The application of blockchain technology can perfectly solve the above problems. However, the data recorded on a blockchain are often multi-type and heterogeneous, and users at different levels such as regulators, enterprises, and consumers have different requirements for data types and granularity. This requires a quick and trustworthy method for monitoring the carbon footprint of enterprises and products. In this paper, the carbon footprint traceability of enterprises and products is taken as an application scenario, and the distributed traceability concept of “traceability off the chain and verification on the chain” is adopted. By reconstructing the pointer of the file structure of the distributed storage, an interactive traceability structure supporting type filtering is constructed, which enables fast retrieval and locating of carbon emission data in the mixed data on the chain. The experimental results show that using the interactive traceability structure that supports type filtering for traceability not only releases the computing power of full nodes but also greatly improves the traceability efficiency of the long-span transaction chain. The proposed carbon footprint traceability system can rapidly trace and track data on an enterprise’s and a product’s carbon footprint, as well as meet the needs of users at all levels for traceability. It also offers more advantages when handling large amounts of data requests.
A Scoping Literature Review of Rural Institutional Elder Care
Authors: Li Mingyang , Ao Yibin , Deng Shulin , Peng Panyu , Chen Shuangzhou , Wang Tong , Martek Igor , Bahmani Homa
Published: August 2022

Under circumstances of pervasive global aging combined with weakened traditional family elder care, an incremental demand for institutional elder care is generated. This has led to a surge in research regarding institutional elder care. Rural residents’ institutional elder care is receiving more attention as a major theme in social sciences and humanities research. Based on 94 articles related to rural institutional elder care, this study identified the most influential articles, journals and countries in rural institutional elder care research since 1995. This was done using science mapping methods through a three-step workflow consisting of bibliometric retrieval, scoping analysis and qualitative discussion. Keywords revealed five research mainstreams in this field: (1) the cognition and mental state of aged populations, (2) the nursing quality and service supply of aged care institutions, (3) the aged care management systems’ establishment and improvements, (4) the risk factors of admission and discharge of aged care institutions, and (5) deathbed matters regarding the aged population. A qualitative discussion is also provided for 39 urban and rural comparative research papers and 55 pure rural research papers, summarizing the current research progress status regarding institutional elder care systems in rural areas. Gaps within existing research are also identified to indicate future research trends (such as the multi-dimensional and in-depth comparative research on institutional elder care, new rural institutional elder care model and technology, and correlative policy planning and development), which provides a multi-disciplinary guide for future research.
Relationships between House Characteristics and Exposures to Metal(loid)s and Synthetic Organic Contaminants Evaluated Using Settled Indoor Dust
Authors: Rasmussen Pat E. , Kubwabo Cariton , Gardner H. David , Levesque Christine , Beauchemin Suzanne
Published: August 2022

This study investigates associations between house characteristics and chemical contaminants in house dust, collected under the nationally representative Canadian House Dust Study (2007–2010). Vacuum samples (<80 µm fraction) were analysed for over 200 synthetic organic compounds and metal(loid)s. Spearman rank correlations between contaminant concentrations in dust and presence of children and pets, types of flooring, heating styles and other characteristics suggested a number of indoor sources, pointing to future research directions. Numerous synthetic organics were significantly associated with reported use of room deodorizers and with the presence of cats in the home. Hardwood flooring, which is a manufactured wood product, emerged as a source of metal(loid)s, phthalates, organophosphate flame retardants/plasticizers, and obsolete organochlorine pesticides such as ∑DDT (but not halogenated flame retardants). Many metal(loid)s were significantly correlated with flame-retardant compounds used in building materials and heating systems. Components of heating appliances and heat distribution systems appeared to contribute heat-resistant chemicals and alloys to settled dust. Carpets displayed a dual role as both a source and repository of dust-borne contaminants. Contaminant loadings (<80 µm fraction) were significantly elevated in heavily carpeted homes, particularly those located near industry. Depending on the chemical (and its source), the results show that increased dust mass loading may enrich or dilute chemical concentrations in dust. Research is needed to improve the characterisation of hidden indoor sources such as flame retardants used in building materials and heating systems, or undisclosed ingredients used in common household products, such as air fresheners and products used for companion animals.
Future Time Perspective and Bedtime Procrastination: The Mediating Role of Dual-Mode Self-Control and Problematic Smartphone Use
Authors: Mao Bo , Chen Shuai , Wei Mingchen , Luo Yali , Liu Yanling
Published: August 2022

This study examined bedtime procrastination predictors and the development process concerning health behavior. Based on temporal self-regulation theory and the self-regulatory framework of time perspective, we examined the effects of future time perspective, dual-model of self-control, and problematic smartphone use on bedtime procrastination. Further, including the mediating role of dual-mode self-control and problematic smartphone use in the effects of future time perspective on bedtime procrastination among 3687 participants (38.73% male; Mage = 16.17 years, SD = 2.42, range = 11–23) Chinese students. The results showed that the future time perspective, dual-mode self-control, and problematic smartphone use had significant predictive effects on bedtime procrastination. Importantly, the negative effect of future time perspective on bedtime procrastination is mediated by the impulse system, control system, and problematic smartphone use separately and serially mediated by the impulse system and problematic smartphone use, rather than the control system and problematic smartphone use; these findings extend previous research on the contributing factors of bedtime procrastination and provide an empirical basis for promoting people to form healthy sleep habits.
Maternal Early-Life Risk Factors and Later Gestational Diabetes Mellitus: A Cross-Sectional Analysis of the UAE Healthy Future Study (UAEHFS)
Authors: Juber Nirmin F. , Abdulle Abdishakur , AlJunaibi Abdulla , AlNaeemi Abdulla , Ahmad Amar , Leinberger-Jabari Andrea , Al Dhaheri Ayesha S. , AlZaabi Eiman , Mezhal Fatima , Al-Maskari Fatma , AlAnouti Fatme , Alsafar Habiba , Alkaabi Juma , Wareth Laila Abdel , Aljaber Mai , Kazim Marina , Weitzman Michael , Al-Houqani Mohammad , Ali Mohammed Hag , Oumeziane Naima , El-Shahawy Omar , Sherman Scott , AlBlooshi Sharifa , Shah Syed M. , Loney Tom , Almahmeed Wael , Idaghdour Youssef , Ali Raghib
Published: August 2022

Limited studies have focused on maternal early-life risk factors and the later development of gestational diabetes mellitus (GDM). We aimed to estimate the GDM prevalence and examine the associations of maternal early-life risk factors, namely: maternal birthweight, parental smoking at birth, childhood urbanicity, ever-breastfed, parental education attainment, parental history of diabetes, childhood overall health, childhood body size, and childhood height, with later GDM. This was a retrospective cross-sectional study using the UAE Healthy Future Study (UAEHFS) baseline data (February 2016 to April 2022) on 702 ever-married women aged 18 to 67 years. We fitted a Poisson regression to estimate the risk ratio (RR) for later GDM and its 95% confidence interval (CI). The GDM prevalence was 5.1%. In the fully adjusted model, females with low birthweight were four times more likely (RR 4.04, 95% CI 1.36–12.0) and females with a parental history of diabetes were nearly three times more likely (RR 2.86, 95% CI 1.10–7.43) to report later GDM. In conclusion, maternal birthweight and parental history of diabetes were significantly associated with later GDM. Close glucose monitoring during pregnancy among females with either a low birth weight and/or parental history of diabetes might help to prevent GDM among this high-risk group.
Data from the PASSI d’Argento Surveillance System on Difficulties Met by Older Adults in Accessing Health Services in Italy as Major Risk Factor to Health Outcomes
Authors: Contoli Benedetta , Possenti Valentina , Gallo Rosaria , Minardi Valentina , Masocco Maria
Published: August 2022

(1) Age-friendly health systems ensure access to quality healthcare services to all people, especially older adults. (2) We used data on elderly population collected from 2016 to 2019 by the Italian ongoing surveillance system PASSI d’Argento to analyze the prevalence and associations between accessing health services and modifiable risk factors included in the 25 × 25 strategy for the burden of noncommunicable diseases with health outcomes. (3) Chronic diseases and hospitalization as descriptors of health status showed that the elderly perceived as having poor access to care and prevention incurred a higher risk of hospitalization. The association between difficulties in accessing health services and hospitalization was always the highest in terms of the adjusted prevalence ratio (aPR), regardless of the other behavioral risk factors considered, controlling each model with sociodemographic conditions. Elderly hospitalized at least once for two days or more in the last 12 months had greater risk to have problems in accessing health services, whereas the model included health conditions such as obesity (aPR = 1.95 95% CI 1.75–2.17), smoking (aPR = 1.95 95% CI 1.76–2.16), alcohol use (aPR = 1.93 95% CI 1.73–2.14), hypertension (aPR = 1.92 95% CI 1.73–2.13) and diabetes (aPR = 1.91 95% CI 1.73–2.12). (4) Health policies should encompass socio-economic and living environment barriers which prevent access to care among older adults.
Variation in Vegetation and Its Driving Force in the Pearl River Delta Region of China
Authors: Chen Shulin , Zhu Zhenghao , Liu Xiaotong , Yang Li
Published: August 2022

Vegetation is an important part of a regional ecological environment and vegetation coverage can reflect the health of a regional ecological environment. Through an analysis of and research into changes in the vegetation NDVI (normalized difference vegetation index) and its driving factors in the Pearl River Delta region, the spatial–temporal pattern of vegetation changes and the driving factors can be measured. It is of significance to improve the ecological environment quality of the Pearl River Delta region and to promote the sustainable development of the regional economy. Based on SPOT/VEGETATION NDVI satellite remote sensing data, meteorological data, population density data, and gross domestic product (GDP) data during the period 2000–2019, this paper analyzed the temporal and spatial trends of the vegetation NDVI as well as the climate factors and human activities in the Pearl River Delta on a pixel scale. The correlations between the vegetation NDVI and precipitation, temperature, population density, GDP, and other factors were also estimated. The results showed that during the period 2000–2019, the annual mean NDVI significantly increased, with a growth rate of 0.0044 (R2 = 0.71, p < 0.0001). The NDVI in the center of the Pearl River Delta was lower than that in other regions. As far as the driving factors of the NDVI were concerned, among the climatic factors, the response of the NDVI to temperature was higher than that for precipitation in the Pearl River Delta. Human activities had changed from a negative hindering effect on the NDVI to a positive promoting effect. The correlation between the NDVI and the GDP was higher than that for population density. Policy factors such as the “Grain for Green Project” as well as an increase in the sown area of crops and land use changes were also important driving factors of the NDVI. It is suggested that the NDVI can be increased by the implementation of artificial afforestation policies, building a “Green City”, and moderately increasing the sown area of crops.
Influence of the COVID-19 Pandemic on Medication Reconciliation in Frail Elderly People at Hospital Discharge: Perception of Healthcare Professionals
Authors: Rojas-Ocaña María Jesús , García-Navarro E. Begoña , García-Navarro Sonia , Macías-Colorado María Eulalia , Baz-Montero Servando Manuel , Araujo-Hernández Miriam
Published: August 2022

The current demographic panorama in Spain corresponds to an aging population; this situation is characterized by the need to care for an elderly population, which contains polymedicated and pluripathological individuals. Polymedication is a criterion of frailty in the elderly and a risk factor for mortality and morbidity due to the increased risk of drug interactions and medication errors. There are numerous studies that measure reconciliation at hospital discharge and at admission, and even the methodology of reconciliation, but we have not found many studies that measure reconciliation in the context of the COVID-19 pandemic from the point of view of health professionals regarding difficulties and the strategies carried out, which is essential to begin to glimpse solutions. Methods. This was a qualitative study based on 21 in-depth interviews and two discussion groups, conducted between January and April 2021 (13 nurses and 8 doctors, in rural and urban areas). The discourse was analyzed according to the Taylor–Bodgan model and processed using Atlas.ti software. Results. The areas altered by the health crisis were access to patients, their reconciliation of medication, and changes in the care modality, including the greater use of telephone communication, changes in work organization, and time dedicated to patient care and family work. Difficulties encountered during COVID-19: change in medication format, the specific characteristics of the patient and their pathologies, and difficulties arising from communication with the patient and their family. The strategies applied: the collaboration of home assistants and caregivers, emphasis on patient–health professional communication, and the use of Information and Communication Technologies (ICT). Conclusion. The discharge was interrupted by the health crisis caused by COVID-19, in terms of both the traditional access of patients and by the remote care modalities generated by telemedicine.
Comparison of Phytoremediation Potential of Nerium indicum with Inorganic Modifier Calcium Carbonate and Organic Modifier Mushroom Residue to Lead–Zinc Tailings
Authors: Su Rongkui , Ou Qiqi , Wang Hanqing , Luo Yiting , Dai Xiangrong , Wang Yangyang , Chen Yonghua , Shi Lei
Published: August 2022

At present, the application of phytoremediation technology in the ecological remediation of heavy metal tailings is receiving more and more attention. In this study, the physiological and biochemical response and tolerance mechanism of woody plant Nerium indicum to Pb and Zn under different proportions of inorganic modifier calcium carbonate (C1: 5%, C2: 10%, C3: 15%) and organic modifier mushroom residue (M1: 10%, M2: 20%, M3: 30%) was compared. The results showed that the pH value has a trend of C group > M group > CK group and organic matter has a trend of M group > CK group > C group. Phosphatase activity and catalase activity has a trend of M group > C group > CK group, but catalase was more vulnerable to the calcium carbonate concentration. Both modifiers can promote the transformation of Pb, Zn, Cu, and Cd in tailings to more stable organic bound and residual states. However, the stabilization effect of mushroom residue is better, and its stability is Pb, Zn > Cd, Cu. Both modifiers can increase the biomass of Nerium indicum and the modification effect of mushroom residue is better than calcium carbonate. Pb/Zn content and accumulation in Nerium indicum organs showed root > stem > leaf in all groups. Compared with the CK group, the enrichment coefficient of Pb/Zn in C1 and M1 groups decreased, while the translocation factor of Pb/Zn in C1 and M1 groups increased. With the increase in modifier concentration, the enrichment coefficient increases about 1.75~52.94%, but the translocation factor decreases rapidly (20.01~64.46%). Clearly, both the calcium carbonate and mushroom residue amendment could promote the growth ability of Nerium indicum in lead–zinc tailings and strengthen the phytoremediation potential.
Identifying Key Factors Associated with Green Justice in Accessibility: A Gradient Boosting Decision Tree Analysis
Authors: Du Sainan , He Huagui , Liu Yanfang , Xing Lijun
Published: August 2022

Park green space (PGS) provides numerous environmental and health benefits for urban residents, and raises the issue of green justice for its uneven distribution in cities. Previous studies focus more on the measurements of spatial equity in accessibility, but are limited in exploring its impacts—especially the nonlinear influence. This study first measures accessibility and equity in two traffic modes, and then explores the nonlinear influence of multidimensional factors by using the gradient boosting decision tree (GBDT) model across the central urban area of Wuhan. The results show significant spatial disparities in spatial accessibility and equity by walking and driving within 15 min. Multidimensional factors—including characteristics of PGS, the built environment, and socioeconomic factors—present stronger nonlinear influences on spatial accessibility and equity, and the nonlinear influence indicates that the contributions of the built environment and socioeconomic factors are greater than those of park characteristics, accounting for at least 79.76%. The key variables affecting the accessibility and equity are not completely consistent, leading to synergistic and heterogeneous effects, which may provide policy implications for streets where accessibility and equity are mismatched. These findings could provide guidance for PGS planning by decision-makers to improve the living environment and urban health.
The Spatial Interaction Effect of Green Spaces on Urban Economic Growth: Empirical Evidence from China
Authors: Zhou Hailing , Liu Yan , He Miao
Published: August 2022

This paper measures the impact of urban green space construction rate on urban economic growth from the perspective of spatial interaction. To this end, we collect panel data of 31 provincial capital cities in China from 2001 to 2020 and use spatial economics models for empirical testing. The research results are summarized as follows: the level of green space construction can attract talents and investment by improving the environmental level of the city, and these financial expenditures, foreign investment, and talents are conducive to urbanization, thus having a significant positive impact on urban economic development. In addition, it also has a significant positive spatial spillover effect. In addition, the construction of urban green space will also stimulate the environmental protection of neighboring cities, which has a significant positive spatial dependence. At this time, talents and investment are affected by the environmental construction of neighboring cities, and the economic development of the city has also been significantly improved. The spatial spillover effect of green space construction on the economic level of surrounding cities is also positive. The empirical conclusions provide references for implementing green development strategies and promoting high-quality economic development.
Association of Short-Term Changes in Menstrual Frequency, Medication Use, Weight and Exercise on Bone Mineral Density in College-Aged Women
Authors: Fleischer Stacie H. , Freire Annalisa K. , Brown Katie , Creer Andrew , Eggett Dennis L. , Fullmer Susan
Published: August 2022

To evaluate if experiencing a short-term exposure (18-months) to factors such as menstrual irregularities, dieting, changes in exercise or body weight, and medication usage is associated with bone mineral density (BMD) in college-aged females. A retrospective survey assessing health behaviors during a recent 18-month time period and a DXA scan were completed in 641 females. A total of 45.5% of participants reported amenorrhea during the 18-month time period. Those who experienced amenorrhea had lower femoral neck BMD (p = 0.018), trochanter (p = 0.018) and spine BMD (p = 0.022) compared to eumenorrheic women. Lifetime oral contraceptive usage longer than six months was negatively associated with BMD at femoral neck (p = 0.018) and total hip (p = 0.021). Women who lost weight trended towards having the lowest BMD at all sites compared to women who gained weight. Following a very-low calorie diet during the time period was negatively correlated with spine BMD (p = 0.001). Time spent in vigorous and very vigorous activity was weakly correlated with some hip BMD sites but time spent in extremely vigorous activity was not. In conclusion, females who experienced weight loss, amenorrhea, or a very low-calorie diet within an 18-month period of time in young adulthood had lower BMD. Additionally, oral contraceptive usage for longer than six months during their lifetime was associated with lower BMD.
Amateur Athlete with Sinus Arrest and Severe Bradycardia Diagnosed through a Heart Rate Monitor: A Six-Year Observation—The Necessity of Shared Decision-Making in Heart Rhythm Therapy Management
Authors: Gajda Robert , Knechtle Beat , Gębska-Kuczerowska Anita , Gajda Jacek , Stec Sebastian , Krych Michalina , Kwaśniewska Magdalena , Drygas Wojciech
Published: August 2022

Heart rate monitors (HRMs) are used by millions of athletes worldwide to monitor exercise intensity and heart rate (HR) during training. This case report presents a 34-year-old male amateur soccer player with severe bradycardia who accidentally identified numerous pauses of over 4 s (maximum length: 7.3 s) during sleep on his own HRM with a heart rate variability (HRV) function. Simultaneous HRM and Holter ECG recordings were performed in an outpatient clinic, finding consistent 6.3 s sinus arrests (SA) with bradycardia of 33 beats/min. During the patient’s hospitalization for a transient ischemic attack, the longest pauses on the Holter ECG were recorded, and he was suggested to undergo pacemaker implantation. He then reduced the volume/intensity of exercise for 4 years. Afterward, he spent 2 years without any regular training due to depression. After these 6 years, another Holter ECG test was performed in our center, not confirming the aforementioned disturbances and showing a tendency to tachycardia. The significant SA was resolved after a period of detraining. The case indicates that considering invasive therapy was unreasonable, and patient-centered care and shared decision-making play a key role in cardiac pacing therapy. In addition, some sports HRM with an HRV function can help diagnose bradyarrhythmia, both in professional and amateur athletes.
Attachment Insecurity and Altruistic Behavior among Chinese Adolescents: Mediating Effect of Different Dimensions of Empathy
Authors: Pan Yangu , Liang Shuang , Shek Daniel T. L.
Published: August 2022

Although Western studies showed that attachment insecurity was negatively related to adolescent altruistic behavior, few studies have investigated this issue among Chinese adolescents, and little is known about the mechanisms underlying the impact of attachment avoidance and attachment anxiety on adolescent altruistic behaviors. This study investigated the mediating role of different dimensions of empathy (empathic concern, perspective taking, and personal distress) on the association of attachment avoidance and attachment anxiety with altruistic behavior among Chinese adolescents. A total of 1005 7th and 8th grade Chinese students (Mage = 12.86 years, SD = 0.69) from three middle schools in Chengdu, China completed measures of attachment insecurity, interpersonal reactivity index, and altruistic behavior. Results indicated that attachment avoidance, not attachment anxiety, negatively predicted adolescent altruistic behavior among Chinese adolescents. Moreover, higher attachment avoidance predicted less empathic concern and perspective taking, which in turn predicted less altruistic behavior, while higher attachment anxiety predicted more empathic concern and personal distress, which further predicted more and less altruistic behavior, respectively. These findings highlight the importance of promoting adolescent empathic concern and perspective taking and reducing personal distress to strengthen adolescent altruistic behavior.
The Effects of 10-Week Strength Training in the Winter on Brown-like Adipose Tissue Vascular Density
Authors: Tanaka Riki , Fuse-Hamaoka Sayuri , Kuroiwa Miyuki , Kurosawa Yuko , Endo Tasuki , Kime Ryotaro , Yoneshiro Takeshi , Hamaoka Takafumi
Published: August 2022

There is no evidence of the effect of exercise training on human brown-like adipose tissue vascular density (BAT-d). Here, we report whether whole-body strength training (ST) in a cold environment increased BAT-d. The participants were 18 men aged 20–31 years. They were randomly assigned to two groups: one that performed ST twice a week at 75% intensity of one-repetition maximum for 10 weeks during winter (EX; n = 9) and a control group that did not perform ST (CT; n = 9). The total hemoglobin concentration in the supraclavicular region determined by time-resolved near-infrared spectroscopy was used as a parameter of BAT-d. ST volume (Tvol) was defined as the mean of the weight × repetition × sets of seven training movements. The number of occasions where the room temperature was lower than the median (NRcold) was counted as an index of potential cold exposure during ST. There was no significant between-group difference in BAT-d. Multiple regression analysis using body mass index, body fat percentage, NRcold, and Tvol as independent variables revealed that NRcold and Tvol were determined as predictive of changes in BAT-d. An appropriate combination of ST with cold environments could be an effective strategy for modulating BAT.