bluuebunny/crossref_metadata_2025 huggingface dataset:
An Accurate Estimation of the Energy Cost of Dynamic Branch Prediction in an Intel High-Performance Processor
Authors: Alqurashi Fahad Swilim , Al-Hashimi Muhammad
Published: June 2023

Power and energy efficiency are among the most crucial requirements in high-performance and other computing platforms. This work examines through extensive experimentation methods and procedures suitable for assessing the power and energy efficiency of fundamental hardware building blocks inside a typical high-performance CPU, focusing on the dynamic branch predictor (DBP). The investigation relies on the Running Average Power Limit (RAPL) interface from Intel, a software tool for credibly reporting the power and energy based on instrumentation inside the CPU. We use well-known microbenchmarks under various run conditions to explore potential pitfalls and to develop precautions to raise the precision of the measurements obtained from RAPL for more reliable power estimation. The authors discuss the factors that affect measurements and share the difficulties encountered and the lessons learned.
Low-Cost Denoising and Deblurring Using a Novel Nonlinear Diffusion Technique
Authors: Funaro Daniele , Fatone Lorella
Published: June 2023

An algorithm for the treatment of images affected by both blurring and salt&pepper noise is proposed with a cost only proportional to the number of pixels. The methodology uses a discretization scheme for the Laplace operator multiplied by a suitable nonlinear term depending on the gradient. Even if this approach resembles a diffusion type algorithm, only one step of the procedure is applied, leading to significant time savings. The procedure is successfully tested on some standard black&white natural images.
Review on Mechanism, Prediction, and Remediation of Salt Deposition in Gas Production Wells
Authors: Wang Duocai , Ren Zhongxin , Li Haichuan , Jiang Ping , Wang Jian , Zhu Yanwei , Zhu Ziheng
Published: June 2023

During the gas production process, the evaporation of formation water leads to an increase in the water content of the gas and increases the salinity of the remaining formation water. Salt deposition generally occurs near the wellbore and in the wellbore. When the wellbore is clogged with salt deposition, it will lead to a rapid decrease in gas well pressure and production. This work analyzes the effects of formation water evaporation, temperature, and pressure on salt deposition in gas wellbore. And the salt deposition mechanism in the wellbore was summarized. This work presented a technical review on the salt deposition prediction in the gas wellbore. Finally, this work summarizes three different techniques for salt deposition remediation in gas wells, including cold-water removal, hot-water washing, and chemical salt prevention. This work can provide a reference for salt deposition prevention and remediation in the underground gas storage.
Morphology and Composition Changes in Fluid Inclusions from Quartz under Progressive Deformation: Case Study of a Vein System in the Western Kelyan-Irokinda Fold Zone (Western Transbaikalia)
Authors: Kungulova E.N. , Tishin P.A. , Lychagin D.V. , Tomilenko A.A. , Moskvichev E.N.
Published: June 2023

—The behavior of fluids during plastic deformation is studied from the morphology and distribution of fluid inclusions in quartz grains of different microstructure types from a vein system controlled by thrusting and strike-slip faulting in the eastern Sayan–Baikal fold area. The analytical work includes electron backscatter diffraction (EBSD) for quartz microstructure and crystallography, as well as Linkam heating-and-freezing analysis and Raman spectroscopy for the composition of fluid inclusions. The studied fluid inclusions are of seven types that differ in morphology and position in the deformed quartz structure. A model is suggested to describe successive structural changes of quartz aggregates during dislocation sliding and subsequent creep-related recrystallization associated with redistribution of fluid. Fluid inclusions undergo qualitative and quantitative changes due to water leakage at all stages of plastic deformation. The changes occur by two main mechanisms: (i) mass transfer during dislocation sliding at medium temperatures and strain rates and (ii) diffusion creep at low strain rates and high temperatures. The contribution of creep increases gradually with temperature, which maintains the interaction of inclusions with migrating grain boundaries.
WITHDRAWN: Evaluation of Micro Hardness and Wear characteristics of Gyroid designed Ti-6Al-4V fabricated through DMLS technique.
Authors: Devaraj Daniel , Vijayaraghavan Srinivasan , Senthil Selvabharathi
Published: June 2023

This work evaluates the wear characteristics of Direct Metal Laser Sintered Ti6Al4V (DMLS-Ti6Al4V) for orthopaedic implant biomedical application. The wear samples were printed by Additive Manufacturing method with optimized input process parameters with TPMS (Triply Periodic Minimal Surface) Gyroid structures. Wear tests using pin-on-disc tribometer was used to assess the Gyroid Ti-6Al-4V wear samples for various loads and sliding velocity. It is found that Gyroid Ti-6Al-4V samples posses more wear resistance than as cast Ti-6Al-4V. The coefficient of friction of Gyroid Ti-6Al-4V ranged between 0.26 and 0.34 and had a consistent mean value of 0.27– 0.33. The micro hardness test results depicted clearly that, the Gyroid Ti-6Al-4V alloy posses’ micro hardness of 408 HV in comparison with as cast Ti-6Al-4V alloys’ hardness of 358 HV. The morphological characteristics of the worn-out samples were investigated using scanning electron microscope. At higher sliding conditions occurrence of large friction events lead to higher wear rates and the periodic localised fracture of transfer layer. At low sliding conditions, the Gyroid Ti-6Al-4V samples experienced ploughing, peeling off, plastic deformation types of wear mechanism.
Psychometric validation of the Danish version of the Major Depression Inventory using data from the Lolland-Falster Health Study (LOFUS)
Authors: Christensen Karl Bang , Packness Aake , Simonsen Erik , Brodersen John
Published: June 2023

Purpose: The Major Depression Inventory (MDI) is a widely used self-rating depression scale commonly in primary care in Denmark. It has not been subject to robust psychometric validation in a general population setting. The aim of this study was to evaluate the psychometric measurement properties of the MDI when applied in the general population.
Methods: We evaluated statistical psychometric validity using modern test theory (confirmatory factor analysis, item response theory models and Rasch measurement theory) testing local independence and differential item function across groups defined by gender, age, education, and chronic disease status. Separate analyses across different strata and across different statistical models were employed.
Results: Regarding structural validity we consistently identified local dependence for the item two pairs (MDI2,MDI3) and (MDI4,MDI5) across strata. This result was confirmed by bifactor CFA models and item screening. We further identified substantial differential item functioning with respect to age group and with respect to chronic disease. We identified quantified the magnitude of this lack of measurement invariance.
Conclusion: The MDI is psychometrically valid in homogenous sub populations, but the disclosed evidence of local dependence means that published estimates of its reliability cannot be trusted. The lack of measurement invariance means that the instrument cannot be used to compare individuals or groups unless they are similar in terms of age group and chronic disease status.
Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: a prospective cohort study
Authors: Ali Ahmad M. S. , Gul Wisha , Sen Jon , Hewitt Sarah-Jane , Olubajo Farouk , McMahon Catherine
Published: June 2023

Introduction: Assessment of the pupillary light reflex (PLR) is a key part of intensive care monitoring of neurosurgical patients, particularly for detecting abnormalities in intracranial pressure (ICP). Quantitative pupillometry using a handheld pupillometer is a reliable method for assessing the PLR. However, many variables are derived from such devices. We therefore aimed to assess the performance of these variables at monitoring ICP. Methods: Sedated patients admitted to a neurocritical care unit in a tertiary neurosurgical centre with invasive ICP monitoring were eligible for inclusion. Hourly measurement of ICP, subjective pupillometry (SP) using a pen torch device, and quantitative pupillometry (QP) using a handheld NeuroOptics NPi-200 Pupillometer system were performed. Results: 561 paired ICP, SP and QP pupillary observations from nine patients were obtained, amounting to 1122 pupillary observations in total. SP and QP had a moderate concordance for measuring pupillary size (κ = 0.62). SP performed poorly at detecting changes in pupillary size (sensitivity = 24%). In 40 (3.6%) observations, SP failed to detect a pupillary response whereas QP did. Moderate correlations against ICP were detected for maximum constriction velocity (MCV), dilation velocity (DV), and percentage change in pupillary diameter (%C). Discriminatory ability at an ICP threshold of > 22mmHg was moderate for MCV (AUC = 0.631), DV (AUC = 0.616), %C (AUC = 0.602), and pupillary maximum size (AUC = 0.625). MCV and %C values were significantly different at different ICP thresholds on ANOVA testing. Conclusion: QP is superior to SP at monitoring pupillary reactivity and changes to pupillary size. Although effect sizes were moderate to weak across assessed variables, our data indicates MCV and %C as the most sensitive variables for monitoring ICP. Further study is required to validate these findings and to establish normal range cut-offs for clinical use.
Improving AlphaFold2-based Protein Tertiary Structure Prediction with MULTICOM in CASP15
Authors: Liu Jian , Guo Zhiye , Wu Tianqi , Roy Raj , Chen Chen , Cheng Jianlin
Published: June 2023

Since demonstrating its outstanding performance in the 14th Critical Assessment of Techniques for Protein Structure Prediction (CASP14) in 2020, AlphaFold2 has become the standard method for protein tertiary structure prediction. One remaining challenge in the field is to further improve the accuracy of AlphaFold2-based protein structure prediction. To address this challenge, we developed a new version of the MULTICOM system to sample diverse multiple sequence alignments (MSAs) and structural templates to improve the input for AlphaFold2 to generate structural models. The models are then ranked by both the pairwise model similarity and AlphaFold2 self-reported model quality score. The top ranked models are further refined by a novel structure alignment-based refinement method powered by Foldseek. Moreover, for a monomer target that is a subunit of a protein assembly (complex), MULTICOM integrates tertiary and quaternary structure prediction together to account for tertiary structural changes induced by protein-protein interaction in the assembly. The MULTICOM system participated in the tertiary structure prediction in 2022 CASP15 experiment as server and human predictors. Our server predictor MULTICOM_refine ranked 3rd among 47 CASP15 server predictors and our human predictor MULTICOM ranked 7th among all 132 human and server predictors. The average GDT-TS score and TM-score of the first structural models that MULTICOM_refine predicted for 94 CASP15 domains are ~0.80 and ~0.92, 9.6% and 8.2% and higher than ~0.73 and 0.85 of the standard AlphaFold2 predictor respectively. The results demonstrate that our approach can significantly improve the accuracy of the AlphaFold2-based protein tertiary structure prediction.
Human equivalent doses of L-DOPA rescues retinal morphology and visual function in a murine model of albinism
Authors: Sanchez-Bretano Aida , Keeling Eloise , Scott Jennifer A. , Lynn Savannah A. , Soundara-Pandi Sudha Priya , Macdonald Sarah L. , Newall Tutte , Griffiths Helen , Lotery Andrew J. , Ratnayaka J. Arjuna , Self Jay E. , Lee Helena
Published: June 2023

L-DOPA is deficient in the developing albino eye, resulting in abnormalities of retinal development and visual impairment. Ongoing retinal development after birth has also been demonstrated in the developing albino eye offering a potential therapeutic window in humans. To study whether human equivalent doses of L-DOPA/Carbidopa administered during the crucial postnatal period of neuroplasticity can rescue visual function, OCA C57BL/6J-c2J OCA1 mice were treated with a 28-day course of oral L-DOPA/Carbidopa at 3 different doses from 15 to 43 days postnatal age (PNA) and for 3 different lengths of treatment, to identify optimum dosage and treatment length. Visual electrophysiology, acuity, and retinal morphology were measured at 4, 5, 6, 12 and 16 weeks PNA and compared to untreated C57BL/6J (WT) and OCA1 mice. Quantification of PEDF, βIII-tubulin and syntaxin-3 expression was also performed. Ourdata showed impaired retinal morphology, decreased retinal function and lower visual acuity in untreated OCA1 micecompared to WT mice. These changes were diminished or eliminated when treated with higher doses of L-DOPA/Carbidopa. Our results demonstrate that oral L-DOPA/Carbidopa supplementation at human equivalent doses during the postnatal critical period of retinal neuroplasticity can rescue visual retinal morphology and retinal function, via PEDF upregulation and modulation of retinal synaptogenesis, providing a further step towards developing an effective treatment for albinism patients.
Title: Does progesterone as predictive for a successful pregnancy along all age groups in fresh IVF/ICSI transfer cycles?
Authors: Ip Patricia Nga Ping , Fung Ka Kei , CHUNG Jacqueline Pui Wah , Zhao Mingpeng , Chan David Yiu Leung
Published: June 2023

Background
Meta-analyses have shown that progesterone (P) elevation is associated with a decreased probability of pregnancy achievement in fresh in vitro fertilization (IVF) cycles. The objective of this study is to evaluate the P level, the P to oocyte ratio (P/O) and the P to follicle (> 14 mm) ratio (P/F) in prediction of successful pregnancy in different age groups.
Methods
This was a retrospective, single-centre cohort study with 1517 cycles performed in 1305 patients undergoing controlled ovarian stimulation and fresh embryo transfer cycles between 2015 and 2021. We investigated the association of serum progesterone level on the day of ovulation trigger with live birth among patients age ≤ 35 (group 1), 36–39 (group 2) and ≥ 40 (group 3).
Results
The progesterone level was significantly associated with the live birth rate in group 1 (aOR 0.422, 95% CI 0.231–0.770, p = 0.005), but not in group 2 (aOR 0.626, 95% CI 0.362–1.084, p = 0.095) and group 3 (aOR 0.311, 95% CI 0.042–2.284, p = 0.251). The live birth rate was significantly reduced in group 1 with P > 1.00 ng/mL (36.8% vs. 23.6%, p = 0.002). No significant difference in the live birth rate was found with P > 1.00 ng/mL in both groups 2 and 3. Both the P/O and P/F ratios, though were more predictive than P alone in live birth rate among all age groups, the values increased substantially with age.
Conclusions
Our results suggest that progesterone elevation is less predictive to live birth rate among patients age above 35. While the P/O or P/F ratio are significantly higher among women without live birth in all 3 age groups, their age-dependent values suggest the definition of a universal threshold should be warranted.
Relationship between coping styles and affective decision- making process among schizophrenia patients and healthy controls
Authors: Kertzman Semion , Rauchverger Boris , Waseem Shiech Zaid , Weizman Abraham , Portuguese Shirley , Grinshpoon Alexander
Published: June 2023

Psychiatry has shown a growing interest in the role of emotion in decision- making because emotion appears to make a substantial contribution to the decision- making process. There are no studies analyzing the relationship between affective decision-making and coping skills in schizophrenia (SZ). Our objective was to investigate the effect of coping skills on decision-making in SZ. We aimed to study the differences in coping styles, measured by the Behavioral Attitudes and Search Evaluation test (BASE), between good and bad performers on the Iowa Gambling Task (IGT). The 37 SZ participants and 46 healthy controls (HC) performed the IGT and BASE. Affective decision-making and coping skills are impaired among individuals with SZ compared with HC. A combination of two coping styles, such as preference for search activity and rejection of renunciation of search, was associated with better performance on IGT in both groups. We demonstrate that the association between coping style and performance on the IGT is not bidirectional. Coping strategies affect IGT performance, while performance on IGT does not affect coping style. In conclusion, participants with a more adaptive coping style were better decision-makers. One possible explanation for this association is that the more effective coping style may represent better functioning of the affective systems.
Digitalization-A Strategic Approach to Promote Garage and Vehicle Services in order to provide effective services in Sri Lanka
Authors: N.A.R Udeshi , R.D.A Shehara , H Weerasinghe , T.D Gajasinghe , De Silva D. I. , H.M.P.P.K.H Samarasekara
Published: June 2023

This web application aims to provide a seamless platform for vehicle owners to locate and book available garage services, and fuel station services, buy available products by visiting shops and get insurance companies according to related features with ease. The application will feature a user-friendly interface that will enable users to browse and compare prices, ratings, and product details offered by different shops. The application will also have a scheduling system for garages that will allow users to book appointments, receive notifications and track the status of their vehicle repairs. This web application is designed to help users locate fuel stations, shops, and garages near their current location quickly and easily. Customers can easily browse and compare insurance plans according to features companies provide directly through the website. Additionally, the application will offer feedback mechanisms to ensure customer satisfaction. The web application aims to simplify the process of maintaining and repairing vehicles while promoting transparency, reliability, and convenience.
Starting-Accessibility / Water Internal Diffusion (SAWID) Phenomenological Model of Myrtle Drying Kinetics
Authors: Berrich oumaima , Allaf Karim , Azzouz Soufien , Besombes Colette , Hamrouni Lamia
Published: June 2023

To avoid empirical modeling and embrace a relevant phenomenological analysis, the present work deals with the conditions allowing to adopt the transfer by internal water diffusion as the limiting process of the whole drying. Verification of the Negligible External Resistance NER criterion has been conducted and the main part of the drying kinetics allows expressing the effective diffusivity Deff of water within the porous material. Moreover, the kinetic experimental data of both the initial and final stages must be excluded. The first one concerns the surface interaction while the last paradoxical stage reveals the vapor transfer within the porous medium. Instant Controlled Pressure-Drop DIC pretreatment was adopted in the drying of myrtle leaves and fruits. An instant pressure drop towards a vacuum occurs after a saturated steam pressure P ranged between 100 and 500 kPa for a short processing time tof20/60s and 10/30 s for myrtle leaves and fruits, respectively. Afterward, the drying experiments were carried out with a constant airflow of 50°C and 2.5 m/s. The phenomenological modeling of drying kinetics was dedicated to well analyzing the impact of DIC operating parameters on the physical and statistical analyses.
Early cumulus cell removal increases cumulative live birth rate while having no negative effect on the malformation rate in in vitro fertilization: a propensity score-matched cohort study
Authors: Sun Li Juan , Liang Shan Shan , Liu Min Hao , Pan Jia Ping , Huang Mei Yuan , Teng Xiao Ming , wu Hai Xia
Published: June 2023

Purpose
The aim of this study was to investigate the efficacy and safety of early cumulus cell removal (ECCR) during human in vitro fertilization (IVF).
Methods
A retrospective analysis was performed between January 2011 and December 2019. The study enrolled 1,131 couples who underwent IVF treatment with ECCR. After propensity score matching at a 1:1 ratio, 1,131 couples who underwent overnight coincubation of gametes were selected. The main outcome measure was the cumulative live birth rate. Secondary outcome measures included the cumulative pregnancy rate, polyspermy rate, available embryo rate, miscarriage rate, malformation rate, time to live birth, and oocyte-to-baby rate.
Results
There were no significant differences found between the two groups in the polyspermy rate, available embryo rate, miscarriage rate, time to live birth, oocyte-to-baby rate, and neonatal congenital anomalies rate. The results of the study showed that ECCR was associated with a significantly higher cumulative live birth rate and cumulative pregnancy rate, along with a significantly lower fertilization rate.
Conclusion
ECCR tended to confer increased cumulative live birth rate and had no negative effect on the neonatal malformation rate.
The associations of natural killer cell functions during the embryo implantation window with pregnancy outcomes in women for whom the number of peripheral blood natural killer cells cannot be applied as a therapeutic index for immunological abnormalities in unexplained recurrent pregnancy loss
Authors: YAN Niwei , LEE Pingyin , JIE Huiying , YUAN Yuan , ZHOU Canquan
Published: June 2023

Study objective The current knowledge on recurrent pregnancy loss (RPL) is largely limited, with up to 70% of RPL cases still classified as unexplained. More than 30% of patients with unexplained recurrent pregnancy loss (uRPL) will suffer an additional pregnancy loss. The majority of scholars are supportive of an immune basis, while clinical data fail to support established therapies. In addition, the effectiveness of immunotherapies is difficult to evaluate because of the lack of diagnostic and predictive indicators. Natural Killer (NK) cells are the largest population of lymphocytes in the endometrium during early pregnancy and play a key regulatory rather than participatory role in the cytotoxic killing reaction to embryos at the maternal-fetal interface. Specifically, they support the invasion of trophoblast cells and embryo implantation. Previous studies on the roles of NK cells with distinct phenotypes in pregnancy loss were based on NK cells derived from the peripheral blood or decidua, and it is difficult to determine whether the reported changes in decidual NK cells are causes or consequences of pregnancy loss. Hence, whether the results of these studies are applicable to the interaction between NK cells and embryonic trophoblast cells during the earliest pregnancy stage remains unknown.Design This study evaluated the expression of 9 receptors and cytokines after coculture of the HTR-8/SVneo human chorionic trophoblast cell line with peripheral blood NK (pbNK) cells and uterine NK (uNK) cells collected during the same embryo implantation window. Then the phenotypes of NK cells during this period were analyzed, and the associations of NK cell functional features with early pregnancy outcomes were explored.Results We found that a decrease in the CD3-CD56 + CD27 + uNK cell population and increases in the frequencies of CD3-CD56 + CD107a + NK cells in women with the recurrence of pregnancy loss.Conclusions CD3-CD56 + IFN-γ + pbNK cells and CD3-CD56 + IFN-γ + uNK cells were immunological risk factors associated with the recurrence of pregnancy loss in uRPL.
Economic Burden of Sanfilippo Syndrome in the United States
Authors: Ashby Frederick , Park Haesuk , Svensson Mikael , Heldermon Coy
Published: June 2023

Introduction: Sanfilippo syndrome is a rare disease and fatal genetic disorder in the United States with no FDA-approved treatment, and no comprehensive assessment of economic disease burden is available.Objective To develop a model to estimate the economic burden associated with Sanfilippo syndrome in the United States (US) using valued intangibles (disability-adjusted life years lost) and indirect burden (lost caregiver productivity) from 2023 onward.Design and Setting: A multistage comorbidity model was generated using publicly available literature on Sanfilippo syndrome disability, and 14 disability weights from the 2010 Global Burden of Disease Study. Attributable increase in caregiver mental health burden and caregiver productivity loss were also estimated using data from the CDC National Comorbidity Survey, retrospective studies on caregiver burden in Sanfilippo syndrome, and the Bureau of Labor Statistics. Monetary valuations were adjusted to USD 2023 and given a 3% discount rate from 2023 onward.Main Outcomes and Measures: Year-over-year incidence and prevalence of Sanfilippo syndrome was calculated for each age group in each year, and year-over-year disability-adjust life years (DALYs) lost due to patient disability was calculated by comparing to health-adjusted life expectancy (HALE), considering years of life lost (YLLs) due to premature mortality and years lived with disability (YLDs). Intangibles were valued in USD 2023, adjusted for inflation and discounted to provide economic burden of disease.Results From 2023–2043, overall economic burden in the US attributable to Sanfilippo syndrome was estimated to be $1.55 billion USD with current standard of care. The burden to individual families exceeded $5.86 million present value from time of birth per child born with Sanfilippo syndrome. These figures are also a conservative estimate, since they do not consider direct cost associated with the disease, as extensive primary data on the direct healthcare cost of Sanfilippo syndrome does not currently exist in the literature.Conclusions and Relevance: Sanfilippo syndrome is a rare lysosomal storage disease, however the severe burden associated with the disease for individual families demonstrates a profound cumulative impact. Our model represents the first disease burden estimate associated with Sanfilippo syndrome. This underscores the substantial morbidity and mortality burden of Sanfilippo syndrome.
Effects of Cell Phone Presence on the Control of Visual Attention During the Navon Task
Authors: Liu Wenjuan , Kawashima Tomoya , Shinohara Kazumitsu
Published: June 2023

Background
Although cell phones can provide great convenience to our lives, research has shown that they can also affect our behavior, even when not in use. It seems that having a cell phone nearby may not be ideal when the user needs to concentrate on work. However, little is known about whether cell phone presence specifically impairs attentional control.
Methods
This study investigated whether cell phone presence can influence attentional control in the Navon task, which involves spatial switching of attention between global and local levels.
Results
It was found that the reaction time for all types of trials decreased when the participants had a cell phone nearby compared to when they had a mobile battery nearby. It was also found that phone dependency led to more incorrect responses among participants, but this effect was independent of the influence of phone presence on the Navon task performance.
Conclusions
These findings indicated that cell phone presence may have a positive influence on the perceptual process of the Navon letter, suggesting that the effects of phone presence are not always negative.
Research on Milling Chatter Monitoring and Suppression Based on IWPEE and VASS Dual Indicators
Authors: Li Xudong , Huang Hua , Zhao Conglin , Nie Xingyi
Published: June 2023

Chatter is harmful for cutting processing, which can cause the surface quality of the workpiece to decline, violent tool wear, even broken tools and workpiece scrap. In order to achieve real-time monitoring and suppression of chatter during the machining process, a milling machining is employed as the research object in this study, and an online monitoring and suppression system for chatter is proposed. Firstly, an improved wavelet packet energy entropy(IWPEE) algorithm is proposed, the recognition accuracy and robustness is improved by this algorithm while the computational complexity is reduced. Secondly, in order to ensure the robustness of the monitoring system in practical application, a variance algorithm for the milling signal sampling is synchronized with the spindle speed(VASS) is proposed by analyzing milling cutter motion through Poincare section. In addition, the position of the spindle rotation is indirectly obtained through mathematical calculations, the signal sampling is ensured synchronized with the spindle rotation period, and the sensors are not necessary so the generalization besides economy is improved. Furthermore, VASS overcomes the defects of IPWEE which is vulnerable to high-frequency noise interference, thereby improving the reliability of chatter monitoring. Then, a dynamic modeling of the cutting system is conducted, and a chatter suppression method based on speed iteration is obtained. Finally, the effectiveness of the proposed chatter monitoring and suppression system is verified through milling experiments.
Graphene/polyacrylamide interpenetrating structure hydrogels for wastewater treatment
Authors: Zhu Xiufang , Wang Zelin , Ren Jian , Zhang Chun , Zhang Jun , Zhou Juying , Li Mufang , Wang Dong , Seok Ilwoo , Guo Xingkui
Published: June 2023

Acrylamide (AM) was used as the initial reaction monomer, N,N-methylene bisacrylamide (MBA) was used as the crosslinking agent, and ammonium persulfate (APS) was used as the initiator to prepare the first network structure. Graphene oxide (GO) aqueous solution was dispersed after heating and reacted with tannic acid (TA) to generate the interpenetrating network structure (IPN). The hydrogel composite was characterized by the Fourier transform infrared, ultraviolet spectrum techniques and scanning electron microscopy to analyze structural characteristics and adsorption interactions. Thermodynamic investigation explored the nature that adding GO into the hydrogel, the thermogravimetric temperature increases with the amount of GO. The reaction kinetics was essentially consistent with the pseudo-second-order model with rate dominated by the intraparticle diffusion model as well as the film diffusion mechanism. The water absorption in the equilibrium state was about 300%, better sorption capacity (110.25 mg/g for nickel chloride).
Cardiac Protective Techniques in Left Breast Radiotherapy: Rapid selection criteria for routine clinical decision making
Authors: Bolukbas Meltem Kirli , Karaca Sibel , Coskun Volkan , Uzel Esengul Kocak
Published: June 2023

Objective: In left breast radiotherapy (RT) desired heart doses may be achieved without heart-sparing RT techniques in some patients. We aimed to examine the existence of predictive factors and cut-off points to determine which patients are the main candidates for heart-sparing RT techniques.
Material and method: Dosimetric data for left breast cancer was examined. RT plans were made at conventional doses to the breast and peripheral lymph nodes. Statistical analyzes were performed using SPSS 22.0 (SPSS Inc.,IBM Corp.,Armonk, NY).
Results: 114 cases were evaluated by ROC analysis in the breast conserving surgery (BCS) and mastectomy groups. While only left lung volume (AUC:0.74, 95%CI:0.61-0.87, p=0.002) was significant in BCS cases, in cases with mastectomy, left lung volume (AUC:0.81, 95%CI:0.69-0.94, p=0.002) and lung/heart volume ratio (AUC:0.83,95%CI:0.70-0.96, p=0.001) had a significant relationship with the relevance of heart doses. The cut-off point of 1.92 was selected for the lung/heart volume ratio for the mastectomized patients. Moreover, the cut-off point 1154 cc and 1208 cc was determined for the left lung volume for the BCS and mastectomized patients, respectively.
Conclusion: Various cut-off points in left breast RT can be used to predict whether RT plans will meet QUANTEC heart dose limits. Evaluating only these few cut-off points before planning makes it possible to eliminate 70% of patients with BCS and 40% of patients with mastectomy from respiratory-controlled methods, which require time and effort. Patients with lung volume and lung/heart volume ratio smaller than the cut-off values can be considered primary candidates for heart-sparing techniques.
Elastically Restrained Cantilever Oscillator: Nonlinear Transcendental Characteristic Equation and Vibration Characteristics in Free and Forced Vibrations
Authors: Babaei Alireza , Parker Johné , Moshaver Paria
Published: June 2023

The efficiency assessment of cantilever-based energy harvesters relies on vibrational analysis, which necessitates modifications aimed at enhancing efficiency. These modifications involve manipulating the fundamental frequency to lower values and encompassing a wider range of resonances within a specified bandwidth. Consequently, this paper introduces an original analytical-numerical exploration into the vibratory response of a cantilever with a novel boundary condition involving an elastically restrained oscillator-spring arrangement. At the beam's tip, an oscillator is elastically confined by a linear spring, resulting in a novel set of coupled governing equations and a distinct shearing boundary condition. During free vibration analysis, a previously unreported characteristic equation is derived. This nonlinear transcendental equation is numerically solved utilizing root-solver algorithms, such as those available in MATLAB. Significantly, it is discovered that the inclusion of a lumped oscillator with an elastic support induces a minimal (new) natural frequency. This finding carries vital implications as the efficiency of cantilever-based energy harvesters is directly contingent upon the resonance frequency. Notably, the oscillator mass and spring constant are two parameters that directly influence the vibratory response of the beam. When employing a stiffer spring, the minimal frequency converges toward the first frequency of the cantilever system. Conversely, the presence of oscillator inertial effects leads to lower minimal frequencies. In the context of forced vibrations, harmonic base excitation is considered as the input excitation, and the mechanical frequency response function is provided. The proposed system offers two distinct advantages for energy harvester systems: the creation of minimal resonance at lower values and the potential to manipulate the system's resonance toward a desired frequency.
Effect of Amhara Credit and Saving Institution (ACSI) to Improve Farmer’s Livelihood: Antsokia Gemza District, Ethiopia
Authors: name Kibret Beyene No family , famil Abebe Fentaw (Ph.D) No
Published: June 2023

The objective of the study was to analyze the effect of ACSI to improve farmers livelihood in Antsokia Gemza Woreda. The study also adopted a mixed research approach with multistage sampling technique to answer research questions from the total 240sampled households 129 of them were participant while 111 were non-participant respondents. Descriptive statistic logit model were used to analyze farmers living standard and factors affecting credit access. The PSM model was also used the effect/impact of ACSI program on beneficiary outcome variable livestock asset, non-livestock asset and annual income .The results of study indicated that ACSI have had a positive influence on the income growth asset accumulation and improvement farmer’s living standard, increase agricultural products, assets and number of livestock for their farmers’ clients. However, there are challenges farmers faced in taking credit from ACSI were high interest rate, size of loan, lending methods. Therefore, concerned body aimed to accelerate growth of farmers’ livelihood in the area could be fruitful. The ACSI should establish a strong and strategic alliance with other stakeholders, apply different incentive mechanisms, individuals may have access to ACSI credit without forming groups, minimizing the loan interest rate, revise regularly the size of loan, .
Atlantic-Pacific salinity contrast enhanced by winds and ocean warming
Authors: Lu Ying , Li Yuanlong , Lin Pengfei , Cheng Lijing , Liu Hailong , Duan Jing , Wang Fan
Published: June 2023

Broad-scale salinity changes have been observed in oceans since the mid-20thcentury. One salient feature is the salinity increase of the Atlantic Ocean (AO) in contrast to the salinity decrease of the Pacific Ocean (PO). Our analysis of observational datasets suggests that this “saltier Atlantic-fresher Pacific” (SAFP) trend occurs primarily in the upper 800 m of the 45°S-45°N band, with notable impacts on regional sea level and ocean stratification. In addition to the surface freshwater fluxes stressed by existing studies, heat- and wind-driven oceanic processes have also vitally contributed to this pattern. Specifically, sea surface warming leads to poleward migration of outcrop zones of the thermocline, while changes in surface winds and overturning circulations cause upper-layer convergence in low- and mid-latitudes. These processes drive basin-scale salt redistribution that involves substantial salinity increases in the 45°S-45°N band of the AO but much weaker signatures in the PO. These effects are confirmed by sensitivity experiments of an ocean-sea ice model. Although climate models can broadly replicate the SAFP pattern, they tend to underestimate the AO salinity increase due to model biases in salinity climatology. This work highlights the essence of ocean processes in the response of ocean salinities to climate change and provides a benchmark for climate models.
Prediction of Lithium-ion Battery SOC Based on the Fusion of MHA and ConvolGRU
Authors: Tang Pei , Hua Jusen , Wang Pengchen , QU Zhonghui , Jiang Minnan
Published: June 2023

Overcharge and overdischarge of the battery can be avoided if the state of charge of lithium-ion battery is predicted accurately. A prediction method combined with convolution layer, gated cycle unit and multi-heads attention mechanism is proposed in this paper in order to improve the prediction accuracy of SOC. The data set uses the data of battery charging and discharging under FUDS conditions and DST conditions from the University of Maryland. The window sliding technology is used in the data preprocessing part. Finally, the prediction effect of the fusion model proposed in this paper is verified by Pycharm simulation. The average absolute error, root mean square error and maximum prediction error of the model are 0.53%, 0.67% and 0.4% respectively, which proves that the SOC can be predicted accurately by this model.
A novel mobility model adapted to multi-obstacle scenarios: obstacle avoidance and smooth motion
Authors: Shi Feiyang , Wang Wei , Zhang Yiguo
Published: June 2023

Most of the existing mobility models use simple, linear motion to describe node movement, and there are few studies on curve movement patterns based on multiple obstacles in real scenes. How to describe the avoidance and curve movement patterns of nodes in multivariate obstacle scenes has become a key difficulty in mobility modeling. To address this, this paper proposes a mobility model based on Hermite curves, which fills the gap in curve mobility models for complex, multivariate obstacle scenes in mobility modeling. Firstly, the paper analyzes the demands of mobile patterns in real scenes, and then theoretically models the Hermite curve direction, combining node movement with Hermite curves to achieve curve movement, and adding perception parameters to avoid obstacles. To study the model's performance in practical scenes, this paper researches the spatial probability distribution of nodes and the spatio-temporal dynamic characteristics of network topology under the model's action, and defines the evaluation indicators of the model. To demonstrate the model's application performance, it is compared with the curve mobility model SRMM and the classic RWPM model. The results show that the model not only adapts to the obstacle avoidance application scenes with multiple obstacles, but also has a more uniform spatial probability distribution of nodes, better spatial coverage, and better spatio-temporal dynamic characteristics of the network topology composed of nodes than the SRMM and RWPM models. This model can provide a more realistic application scenes for the simulation of MANET.
Effects of sodium acetate and ammonium acetate on the growth and production of cellular components by Chlorella vulgaris 31
Authors: Peng Shuting , Cao Yueqin , Xie Zijian , Zhang Xiaoyun , Ma Saimai , Kong Weibao
Published: June 2023

Mixotrophic cultivation using organic carbon sources has become increasingly important for large-scale production and application of microalgae, as it can overcome the current commercial bottleneck of low yield and high cost associated with photoautotrophic and heterotrophic cultivation. In this study, we investigated the effects of adding two acetates, sodium acetate (NaAc) and ammonium acetate (NH4Ac), at different concentrations (2, 4, 6, 8, 10 and 12 g L-1) on the biomass, biochemical components content (pigments, proteins, soluble sugars and lipids) and fatty acid composition of Chlorella vulgaris 31 (Cv-31) under mixotrophic cultures. Our results showed that the addition of NaAc significantly increased the biomass and lipid content of microalgae compared with NH4Ac, with 10 g L-1 NaAc having the best effect on the growth and lipid synthesis. Furthermore, only 2 and 4 g L-1 NaAc promoted the synthesis of pigments in algal cells, while all different concentrations of NH4Ac were inhibitory. In contrast to pigments, the effect of two acetates on protein synthesis was opposite, which was promoted by low concentrations of NH4Ac. Both acetates had a "low concentration promotion, high concentration inhibition" effect on the synthesis of soluble sugars. Moreover, the percentage of saturated fatty acids in the fatty acid profile increased with the amount of NaAc supplementation, while stearic acid and oleic acid appeared. Our findings suggest that regulating the type and concentration of acetate can improve the biomass and lipid yield of Cv-31 to promote the microalgal biomass production.
Propagation wave solutions with non-local nonlinearityfor stochastic NLSE
Authors: Alhojilan Yazid , Samir Islam
Published: June 2023

In this research article, the stochastic nonlinear Schr¨odinger equation (NLSE) with non-local nonlinearity is considered. This model is used to mimic the wave propagation through optical fibers. Theintegration technique of the improved modified extended tanh scheme is implemented to handle theinvestigated model. Many stochastic solutions are raised such as bright solitons, dark and singular solitons. 3D and 2D visualizations are introduced with different noise intensities to show the robust of theextracted solutions against the noise.
PMM2 controls ERα levels and cell proliferation in ESR1 Y537S variant expressing breast cancer cells
Authors: Cipolletti Manuela , Acconcia Filippo
Published: June 2023

Purpose:
Metabolic reprogramming in breast cancer (BC) subtypes offers potential personalized treatment targets. Estrogen receptor α (ERα)-positive BC patients undergoing endocrine therapy (ET) can develop ET-resistant metastatic disease. Specific mutations, like Y537S in ERα, drive uncontrolled metastatic cell proliferation. Targeting mutant receptor levels shows promise for inhibiting growth in metastatic BC expressing ERα variants. Additionally, metabolic reprogramming occurs in ERα Y537S mutant cells. Consequently, we conducted a screen to identify metabolic proteins reducing intracellular levels of ERα Y537S and inhibiting cell proliferation.
Methods:
Nine metabolic proteins were identified in a siRNA-based screen, with phosphomannose mutase 2 (PMM2) showing the most promise. We measured the impact of PMM2 depletion on ERα stability and cell proliferation in ERα Y537S mutant cells. Additionally, we tested the effect of PMM2 reduction on the hyperactive phenotype of the mutant and its proliferation when combined with metastatic BC treatment drugs.
Results:
PMM2 emerged as a significant target due to its correlation with better relapse-free survival, overexpression in ERα-positive tumors, and its elevation in ERα Y537S-expressing cells. Depletion of PMM2 induces degradation of ERα Y537S, inhibits cell proliferation, and reduces ERα signaling. Notably, reducing PMM2 levels re-sensitizes ERα Y537S-expressing cells to certain ET drugs and CDK4/CDK6 inhibitors. Mechanistically, depletion of PMM2 leads to a reduction in ESR1 mRNA levels, resulting in decreased ERα receptor protein expression. Furthermore, reduction of PMM2 decreases FOXA1 levels, which plays a crucial role in ERα regulation.
Conclusions:
Our findings establish PMM2 as an innovative therapeutic target for metastatic BC expressing the ERα Y537S variant, offering alternative strategies for managing and treating this disease.
Longitudinal Trajectory of Spontaneous Brain Activity Changes in Breast Cancer Patients Following One Circle and the Completion of Neoadjuvant Chemotherapy-a preliminary prospective study
Authors: Hu Yixin , Yu Hong , Lai Yong , Liu Jiang , Tan Yong , Lei Weiwei , Zhang Jing , Zhou Xiaoyu , Cao Ying , Tang Yu , Liu Daihong , Zhang Jiuquan
Published: June 2023

There is growing evidence that brain activity changes in breast cancer patients after chemotherapy. However, the longitudinal changes in brain function during chemotherapy are unclear and not studied before. To assess trajectory of brain activity changes during chemotherapy, we prospectively enrolled 36 breast cancer patients and longitudinally compared amplitude of low-frequency fluctuation (ALFF) and neuropsychological tests at three time points including before neoadjuvant chemotherapy (NAC) (time point 0, TP0), before the second cycle of NAC (time point 1, TP1), and after NAC (pre-operation, time point 2, TP2). Compared with TP0, ALFF values of right orbital part of inferior frontal gyrus, left medial orbital part of the superior frontal gyrus, right insula, left medial part of superior frontal gyrus and right middle frontal gyrus decreased significantly at TP1 and TP2. Besides, the score of Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) decreased significantly at both TP1 and TP2. The scores of Self-Rating Anxiety Scale and Perceived Cognitive Abilities have a significant decrease at TP1 and TP2, respectively. There was no statistically significant difference found between the scores on the neuropsychological tests at TP1 and TP2. And aberrant ALFF values were correlated with neuropsychological tests scores at TP0. We conclude that brain activity of breast cancer patients treated with NAC changed significantly after the first cycle of NAC and lasted until the end of chemotherapy, along with the cognitive function deterioration. Most brain regions with ALFF changes were located in the frontal lobe, which is involved in the higher-order of cognitive function.