bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-wide identification, phylogenetic and expression pattern analysis of GATA family genes in Brassica napus
Authors: Zhu Weizhuo , Guo Yiyi , Chen Yeke , Wu Dezhi , Jiang Lixi
Published: December 2020

Background: Transcription factors GATAs are involved in plant developmental processes and respond to environmental stresses through binding DNA regulatory regions to regulate their downstream genes. However, little information on the GATA genes in Brassica napus is available. The release of the reference genome of B. napus provides a good opportunity to perform a genome-wide characterization of GATA family genes in rapeseed.Results: In this study, 96 GATA genes randomly distributing on 19 chromosomes were identified in B. napus, which were classified into four subfamilies based on phylogenetic analysis and their domain structures. The amino acids of BnGATAs were obvious divergence among four subfamilies in terms of their GATA domains, structures and motif compositions. Gene duplication and synteny between the genomes of B. napus and A. thaliana were also analyzed to provide insights into evolutionary characteristics. Moreover, BnGATAs showed different expression patterns in various tissues and under diverse abiotic stresses. Single nucleotide polymorphisms (SNPs) distributions of BnGATAs in a core collection germplasm are probably associated with functional disparity under environmental stress condition in different genotypes of B. napus.Conclusion: The present study was investigated genomic structures, evolution features, expression patterns and SNP distributions of 96 BnGATAs. The results enrich our understanding of the GATA genes in rapeseed.
Preoperative platelet count predicts posttransplant portal vein complications in orthotopic liver transplantation: a propensity score analysis
Authors: Li Qingshan , Wang Yue , Ma Tao , Ren Fenggang , Mu Fan , Wu Rongqian , Lv Yi , Wang Bo
Published: December 2020

Background: The role of platelets on the prognosis of patients with liver transplantation remains unclear. Thus, we aimed to evaluate the influence of preoperative platelet count on postoperative morbidity after liver transplantation. Methods: Clinical data of the patients who received liver transplantation from January 2015 to September 2018 were evaluated. Results: Of the 329 patients included, the average age was 46.71±0.55 years, and 243 were men (75.2%). The incidence of posttransplant portal vein complication was significantly higher in the high platelet count group (> 49.5×109/L; n=167) than in the low platelet count group (≤ 49.5×109/L, n=162, 12.6% vs. 1.9%). After multivariable regression analysis, high platelet count was independently associated with postoperative portal vein complication (odds ratio [OR]: 8.821, 95% confidence interval [CI]: 2.260 to 34.437). After the inverse probability of treatment weighting analysis, patients in the high platelet count group had significantly higher risk of portal vein complication (OR: 9.210, 95%CI: 1.907 to 44.498, p=0.006) and early allograft dysfunction (OR: 2.087, 95%CI: 1.131 to 3.853, p=0.019). Conclusions: Preoperative platelet count > 49.5×109/L was an independent risk factor for posttransplant portal vein complication and early allograft dysfunction. High preoperative platelet count could be an adverse prognostic predictor for liver transplantation recipients.
Clinicopathological features and recurrence patterns of combined hepatocellular-cholangiocarcinoma
Authors: Ishii Takamichi , Ito Takashi , Sumiyoshi Shinji , Ogiso Satoshi , Fukumitsu Ken , Seo Satoru , Taura Kojiro , Uemoto Shinji
Published: December 2020

Background: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a primary liver carcinoma with both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) components. We examined the clinicopathological characteristics and recurrence patterns of cHCC-CCA. Because of the rarity of cHCC-CCA, its etiology, clinicopathological features, and prognosis in comparison with other primary liver carcinoma remain unknown. Its recurrence pattern and sites in particular also need to be elucidated.Methods: All patients who underwent hepatectomy for primary liver malignancies between 2005 and 2015 were retrospectively included in this study. Results: Eight hundred and ninety-four hepatectomies were performed. Nineteen cases of cHCC-CCA (2.1%) in 16 patients were enrolled. Three patients underwent re-hepatectomy. The background of hepatitis viruses and tumor marker patterns of cHCC-CCA were similar to those of HCC and dissimilar to those of intrahepatic CCA (iCCA). Biliary invasion was common in cHCC-CCA and iCCA. The 5-year overall survival values of the cHCC-CCA, HCC, and iCCA patients were 44.7%, 56.6%, and 38.5%, respectively. The 5-year recurrence-free survival values of the cHCC-CCA, HCC, and iCCA patients were 12.2%, 28.7%, and 32.9%, respectively. The liver was the most common recurrence site. Unlike HCC, however, the lymph node was the second-most common recurrence site in both cHCC-CCA and iCCA. Pathological samples of the recurrent lesions were obtained in six patients, and four had cHCC-CCA recurrence pathologically.Conclusion: cHCC-CCA had a mixture of characteristics of HCC and iCCA. Many cases of cHCC-CCA remained cHCC-CCA pathologically even after recurrence.
Required concentration index quantifies effective drug combinations against hepatitis C virus infection
Authors: Kakizoe Yusuke , Koizumi Yoshiki , Ikoma Yukino , Ohashi Hirofumi , Wakita Takaji , Iwami Shingo , Watashi Koichi
Published: December 2020

Successful clinical drug development requires rational design of combination treatments based on preclinical data. Anti-HCV drugs exhibit significant diversity in antiviral effect. Dose-response assessments can be used to determine parameters profiling the diverse antiviral effect during combination treatment. In the current study, a combined experimental and mathematical approaches were used to compare and score different combinations of anti-hepatitis C virus (HCV) treatments. A “required concentration index” was generated and used to rank the antiviral profile of possible double- and triple-drug combinations against HCV genotype 1b and 2a. Rankings varied based on target HCV genotype. Interestingly, multidrug (double and triple) treatment not only augmented antiviral activity, but also reduced genotype-specific efficacy, suggesting another advantage of multidrug treatment. The current study provides a quantitative method for profiling drug combinations against viral genotypes, to better inform clinical drug development.
Systemic inflammation-based predictors of pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients: A propensity score matching analysis
Authors: Xu Ning , Li Wenliang , Huang Fengchang , Yang Jun , Wen Zhengqi , Yin Liang , Zhang Yunfei , Zhao Jingjiao , Zhou Ruize , Yang Jingyu
Published: December 2020

Background: In the management of locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (CRT), the relationship between systemic inflammation-based predictors and tumor response remains unclear. This study aimed to determine whether these inflammatory factors can predict tumor response.Methods: Totally 205 LARC patients underwent neoadjuvant CRT and curative surgery between 2008 and 2017 were analyzed. After propensity score matching, 146 patients (73 matched pairs) were included in this study. The hematological parameters were collected and their relationship with tumor response was investigated.Results: After propensity score matching, the neutrophil-lymphocyte-ratio (NLR) and platelet-lymphocyte-ratio (PLR) before CRT in good response group were significantly lower than those in poor response group, while there was no significant difference in all hematological characteristics between two groups after CRT. The cutoff values​​ of pre-CRT NLR and pre-CRT PLR were 3.10 and 198.7 after receiver operating characteristic analysis. Multivariate analysis model indicated that pre-CRT PLR was not related with tumor response, while pre-CRT NLR≥3.1 was the predictor of poor tumor response (OR=2.047, 95%CI =1.241-3.377, p=0.005). Besides, patients with NLR≥3.1 had a significantly poor tumor regression grade rates compared with patients with NLR<3.1 (p=0.036).Conclusion: The increased NLR before CRT can be regarded as a hematological factor for poor tumor response in LARC, and higher NLR also represents worse tumor regression grade.
Automatic Segmentation of Coronary Lumen and External Elastic Membrane in Intravascular Ultrasound Images Using 8-layer U-Net
Authors: Dong Liang , Lu Wei , Jiang Jun , Zhao Ya , Song Xiangfen , Leng Xiaochang , Zhao Hang , Wang Jian’an , Li Changling , Xiang Jianping
Published: December 2020

Background: Intravascular ultrasound (IVUS) is the golden standard in accessing the coronary lesions, stenosis, and atherosclerosis plaques. In this paper, a fully-automatic approach by an 8-layer U-Net is developed to segment the coronary artery lumen and the area bounded by external elastic membrane (EEM), i.e. cross section area (EEM-CSA). The database comprises of single-vendor and single-frequency IVUS data. Particularly, the proposed data augmentation of MeshGrid combined with flip and rotation operations is implemented, improving the model performance without pre- or post-processing of the raw IVUS images.Results: The mean intersection of union (mIoU) of 0.937 and 0.804 for the lumen and EEM-CSA respectively were achieved, which exceeded the manual labeling accuracy of the clinician.Conclusion: The accuracy shown by the proposed method is sufficient for subsequent reconstruction of 3D IVUS images, which is essential for doctors’ diagnosis in the tissue characterization of coronary artery walls and plaque compositions, qualitatively and quantitatively.
Erythropoietin supports the growth and function of Sca-1+ stem cells and promotes myocardial infarction repair in mice
Authors: Zuo Lin , Li Duan-duan , Ma Xiu-Xia , Shi Shan-Hui , Lü Ding-Chao , Shen Jing , Zhang Wei-Fang , Gao Er-he , Cao Ji-min
Published: December 2020

Background：Myocardial infarction (MI) is the leading cause of death in the world-wide population. With the improvement of clinical therapy, the mortality in acute MI cases has been significantly reduced. This study was to demonstrate that erythropoietin (EPO) is an effective supporter for Sca-1+ stem cells (SCs) and can promote the repair of myocardial infarction (MI) partially via the way of enhancing Sca-1+ SCs activities. Methods: Darbepoetin alpha (a long-acting EPO analog, EPOanlg) (30 mg/kg) was injected into the border zone of MI in adult mice. Infarct size, cardiac remodeling and performance, cardiomyocytes apoptosis and regenerations and microvessels density were measured. Lin− Sca-1+ SCs were isolated from neonatal and adult mice hearts and were respectively used to identify the colony forming ability and the supporting effect of EPO on these Sca-1+ SCs. Results: Compared to MI alone, EPOanlg reduced the infarct percentage and cardiomyocyte apoptosis ratio and LV chamber dilatation, improved cardiac performance, increased the regenerated cardiomyocyte ratio in the border zone and the numbers of coronary microvessels, while without obvious adverse effects in vivo. In vitro, EPO increased the proliferation, migration and clone formation of Lin- Sca-1+ SCs likely via the EPO receptor and Stat5-p38MAPK signaling. Conclusions: EPO promotes Sca-1+ SCs activities and MI repair. The study enlightens the prospects of Sca-1+ SC supporters in the treatment of MI.
Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women
Authors: Dhiman Pooja , Pillai Raji R , Wilson Anand B , Premkumar Nancy , Bharadwaj Balaji , P Veena , Rajendiran Soundravally
Published: December 2020

BackgroundVitamin B12 is an essential micronutrient for neurological function, as it leads to the regeneration of methionine from homocysteine, which is precursor of biologically active molecule S-Adenosyl Methionine (SAM). Pregnancy is a state of increased demand and delayed postpartum repletion of nutrients may predispose women to depression.MethodsWe included women who visited the hospital at 6-weeks postpartum for a regular checkup. Inclusion criteria were age (18 -50 years), and willingness to donate venous sample for analysis. Exclusion criteria included previous history of mood disorders or antidepressant medication use, and any systemic illness like hypothyroidism, epilepsy, diabetes, and hypertension. Based on EPDS score of 10 as a cutoff, 217 women with probable postpartum depression (PPD) and equal number of age and BMI matched controls were included.Plasma total vitamin B12, holotranscobalamin (holotc), homocysteine (hcy), methyl malonic acid (MMA), 5-methyl tetrahydrofolate (THF), SAM and serotonin levels were estimated using commercially available ELISA kits. Combined B12 (cB12) score was calculated from study parameters. Multivariate analysis was performed to assess the risk of probable postpartum depression.ResultsTotal vitamin B12 and combined B12 score were found to be significantly lower (p=0.001) and MMA (p=0.002) and 5-methyl THF (p<0.001) levels were higher in women with probable depression than women without probable PPD. Women in the lowest vitamin B12 quartile had 4.53 times higher likelihood of probable postpartum depression (p < 0.001). Multivariate analysis demonstrated that decreasing vitamin B12 (OR = 0.394; 95% CI: 0.189-0.822) and cB12 (OR=0.293; 95% CI:0182-0.470) and increasing MMA (OR = 2.14; 95% CI: 1.63-2.83) and 5-methyl THF levels (OR = 3.29; 95% CI: 1.59-6.83) were significantly associated with the risk of probable PPD.ConclusionLow vitamin B12 may contribute to depressive symptoms in vulnerable postpartum period.
Family function fully mediates the relationship between social support and depression among antenatal and postpartum women in rural Southwest China
Authors: Huang Yilin , Liu Yan , Wang Yu , Liu Danping
Published: December 2020

Background: Antenatal and postpartum depression is the most common complication of gestation and childbearing affecting women and their families, and good social support and family function are considered the protective and modifiable factors. This study aimed to investigate the depression status and to clarify the interrelationships between social support and depression considering the influence of family function among antenatal and postpartum women in rural areas of Southwest China.Methods: This is a cross-sectional study. Data were collected from a total of 490 rural antenatal (N=249) and postpartum(N=241) women (age: 28.17± 5.12). A structural equation modeling (SEM) was used to test the hypothesized relationships among the variables. The following instruments were used: the Edinburgh Postpartum Depression Scale (EPDS), the APGAR Family Care Index Scale, and the Social Support Rate Scale (SSRS).Results: We found that the prevalence of depression was 10.4%. Path analysis showed that family function had a direct negative correlation with depression (β =-0.251, 95%CI: -0.382 to -0.118). Social support had a direct positive correlation with family function (β =0.293, 95%CI: 0.147 to 0.434) and had an indirect negative correlation with depression (β =-0.074, 95%CI: -0.139 to -0.032), family function fully mediated the relationship between social support and depression. Conclusions: Findings of this study highlight that family function should be considered as the key target for interventions aiming to lower the prevalence of antenatal and postpartum depression. Family members interventions are critical to reduce depression among antenatal and postpartum women.
QTL detection for bread wheat processing quality in a nested association mapping population of semi-wild and domesticated wheat varieties
Authors: Hu Junmei , Xiao Guilian , Jiang Peng , Zhao Yan , Zhang Guangxu , Ma Xin , Yao Jie , Xue Lixia , Su Peisen , Bao Yinguang
Published: December 2020

Background: Wheat processing quality is an important factor in evaluating overall wheat quality, and dough characteristics are important when assessing the processing quality of wheat. As a notable germplasm resource, semi-wild wheat has a key role in the study of wheat processing quality.Results: In this study, four dough rheological characteristics were collected in four environments using a nested association mapping (NAM) population consisting of semi-wild and domesticated wheat varieties to identify quantitative trait loci (QTL) for wheat processing quality. A total of 49 QTL for wheat processing quality were detected, explaining 0.36–10.82% of the phenotypic variation. These QTL were located on all wheat chromosomes except for 2D, 3A, 3D, 6B, 6D and 7D. Compared to previous studies, 29 QTL were newly identified. Four novel QTL, QMlPH-1B.4, QMlPH-3B.4, QWdEm-1B.2 and QWdEm-3B.2, were stably identified in three or more environments, among which QMlPH-3B.4 was a major QTL. Moreover, eight important genetic regions for wheat processing quality were identified on chromosomes 1B, 3B and 4D, which showed pleiotropy for dough characteristics. In addition, out of 49 QTL, 15 favorable alleles came from three semi-wild parents, suggesting that the QTL alleles provided by the semi-wild parent were not utilized in domesticated varieties.Conclusions: The results show that semi-wild wheat varieties can enrich the existing wheat gene pool and provide broader variation resources for wheat genetic research.
Predictive value of clinical toxicities of chemotherapy with fluoropyrimidines and oxaliplatin in colorectal cancer by DPYD and GSTP1 gene polymorphisms
Authors: Deng Xunwei , Hou Jingyuan , Deng Qiaoting , Zhong Zhixiong
Published: December 2020

Background: Fluoropyrimidines and platinum are still widely used for colorectal cancer (CRC) management. Several studies have reported that mutations of dihydropyrimidine dehydrogenase (DPYD) and glutathione S-transferase pi-1 (GSTP1) polymorphisms are related to Chemotherapy-related adverse events. In the present study, we purposed to assess the impact of DPYD and GSTP1 variants on the toxicity of adjuvant chemotherapy risk among the Hakka population, minimize adverse events, and to maximize therapy outcome for individualized treatment.Methods: Genotyping was examined in 104 patients diagnosed with CRC cases and receiving fluoropyrimidine and platinum drugs based chemotherapy regimen by direct sequencing of DPYD and GSTP1 polymorphisms. Three DPYD variants including *2A, *5A, *9A, and GSTP1 c.313A>G were analyzed and clinical outcomes were assessed.Results: The data suggest that the incidence of DPYD*5A, DPYD*9A, and GSTP1 c.313A>G variants were 38.4%, 24%, and 32.7%, respectively. DPYD*2A variant was not found. A total of 23 patients (22.1%) suffered severe vomiting and 19 patients (18.3%) suffered severe anemia. DPYD*5A polymorphism was found significantly associated with grade 3/4 ulceration (p = 0.001). GSTP1 was determined to be an independent risk factor for severe vomiting and skin ulceration (p = 0.042 and p = 0.018, respectively). Patients with GSTP1 c. 313A>G mutant type contributed to a higher risk for grade severe toxicity compared with wild genotype (p = 0.027). Nevertheless, no significant difference was found between patients with DPYD*2A, *5A, *9A for chemotherapeutic toxicity.Conclusions: The results demonstrated that GSTP1 polymorphisms were useful predictors of severe events. Screening of single nucleotide polymorphisms of GSTP1 in colorectal cancer patients before chemotherapy may help to realize personalized therapy.
Effect of Ethyl Acetate, Time and Particle Size on the Kinetics of the Oleoresin Extraction Process
Authors: Olakunle M. S. , Ameh A. O. , Oyegoke T. , Shehu H. U.
Published: December 2020

The kinetics of the extraction of oleoresin from ginger using ethyl acetate as the solvent was studied in this work. The effects of particle size and extraction time on oleoresin’s solvent extraction were studied to obtain optimization data. The temperature of the process was kept constant at 40 °C. The Ginger particle sizes considered ranged between 1200-250 microns at extraction times ranging between 10–70 minutes. Experimental data generated were fitted into an empirical model to determine the kinetic parameters. The oleoresin yield increases with increasing extraction time up to an optimum time, after which the yield remains constant and yield also increases with decreasing particle size. The results obtained from the kinetics studies revealed that the introduction of the constant term accounting for the diffusion step separately (as an addition) into a single step first-order model (Patricelli’s first order model) raises the R-squared values from 87 % fitness of the model into becoming 99 % with the experimental data. This improved form of Patricelli’s first-order model was found to show a good agreement with Patricelli’s 2-step kinetic model. These findings confirmed that the oleoresin extraction process in the presence of ethyl acetate was found to be first-order kinetics involving two steps mechanism where the use of a single-step first-order model (Patricelli’s first-order kinetic model) and the choice of using ethyl acetate must have contributed to the strong resistance present in the first step of the extraction mechanism especially for the smaller particle size (250 microns). In getting the extraction yield improved, this study, therefore, recommends the use of small particle sizes (< 250 microns), higher temperatures (> 40 °C), and/or better alternative solvents like ethanol.

Keywords: ethyl acetate, extraction, oleoresin, modeling.
Influence of Heat Treatment Technologies on the Structure and Properties of the Corrosion-Resistant Martensitic Steel Type AISI 420
Authors: Lupyr O. , Hovorun T. , Vorobiov S. , Burlaka А. , Khvostenko R.
Published: December 2020

One of the methods for increasing the complexity of chromium steel properties of martensitic class AISI 420 is the use of an optimal heat treatment mode. The steel of martensitic class AISI 420 has high resistance in atmospheric conditions (except for the sea atmosphere), in the river, and tap water. It is widely used in power engineering, in cracking units with a long service life at temperatures up to 500 °C, for furnace parts. Additionally, it is used in the following fields: the production of turbine blades, working in conditions of high temperatures and parts of increased plasticity, subject to shock loads, for products exposed to atmospheric precipitation, solutions of organic salts and other slightly aggressive environments; production of fasteners; production of parts for compressor machines operating with inert gas; production of parts operating at low temperatures in corrosive environments; production of parts for aviation purposes. It is shown that the optimal mode of heat treatment for a maximum hardness of 40 HRC is quenching at a temperature of 980 °C with cooling in oil and tempering at a temperature of 200 °C with air cooling. With an increase in the tempering temperature from 200 °C to 450–500°C, the impact strength does not change much. Tempering at higher temperatures leads to the intense weakening of the steel. Simultaneously, a decrease in the impact strength is observed, the minimum value is reached at a tempering temperature of 550 °C. With an increase in the tempering temperature to 700 °C, the impact toughness increases, but the steel’s hardness sharply decreases at such temperatures.

Keywords: hardening, tempering, hardness, toughness, mechanical properties, chromium carbide.
THE MEDIATING EFFECT OF WORK MOTIVATION BETWEEN THE PSYCHOSOCIAL ENVIRONMENT AND NURSES JOB PERFORMANCE
Authors:   Assistant Professor, College of Nursing, University of Hail, Hail City, Kingdom of Saudi Arabia., Pacheco Haidee , Dennis Dayrit Richard ,   Assistant Professor, College of Nursing, University of Hail, Hail City, Kingdom of Saudi Arabia., Mishaanmashi Al Rashidi Areej ,   Staff Nurse, Hail General Hospital, Ministry of Health, Hail City, Kingdom of Saudi Arabia., Fahad Hamood Al Enezi Maalih ,   Staff Nurse, Hail General Hospital, Ministry of Health, Hail City, Kingdom of Saudi Arabia., George Jisha ,   Staff Nurse, Hail General Hospital, Ministry of Health, Hail City, Kingdom of Saudi Arabia., Nawaf Hazza Al Shammari Manal ,   Staff Nurse, Hail General Hospital, Ministry of Health, Hail City, Kingdom of Saudi Arabia., Mohd Al Shammari Ahlam ,   Staff Nurse, Hail General Hospital, Ministry of Health, Hail City, Kingdom of Saudi Arabia.
Published: December 2020

Introduction:This study aimed to determine the level of motivation, psychosocial work environment support, and job performance. Further, it aimed to determine the relationship of motivation, psychosocial work environment, and job performance, and the mediating effect of motivation to psychosocial work environment, and job performance. Methods: The researchers employed a quantitative-cross sectional approach involving the 245 nurses working at the government hospitals of Hail city, Kingdom of Saudi Arabia. The 245 participantswere generated through snowball sampling. Descriptive statistics were used for the demographic profile. The path analysis using analysis of moment structures was utilized to determine the significance between psychosocial work environment, motivation, and job performance, and the mediating effect of work motivation on the psychosocial environment and job performance. Results:There is a high psychosocial work environment support level (x=4.70Â±1.050), moderate work motivation (x=3.87Â± 0.859) and good (33.5%) to excellent (33.5%) work performance of nurses. The psychosocial work environment support found no significant difference to motivation (p>0.029) but significant to job performance (p< 0.002).Meanwhile, the motivation on job performance found not significant (p>0.342). There is no mediating effect of motivation to psychosocial work environment support and job performance. Conclusion:The psychosocial work environment significantly relates to job performance, however, the psychosocial environment on motivation and job performance were found not significant. Conversely, there was no mediating effect of motivation on psychosocial work environment and job performance.
THE FEASIBILITY OF ISLAMIC ASTROTOURISM IN MALAYSIA
Authors:   Research Centre for Sharia, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Hafiz Safiai Mohd ,   Institute of Islam Hadhari, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Firdaus Ab Rahman Muhamad ,   Faculty of Sharia and Law, Universiti Sains Islam Malaysia, 71800 Bandar Baru Nilai, Negeri Sembilan, Malaysia., Zulfazdlee Abul Hassan Ashari Mohamad ,   Research Centre for Arabic Language and Islamic Civilization, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Azraai Jamsari Ezad ,   Research Centre for Arabic Language and Islamic Civilization, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Ilyana Muhd Adnan Nurul ,   Research Centre for Sharia, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.
Published: December 2020

Islamic astrotourism is a form of tourism that involves the sites with astronomical, historical and archaeological interest such as observatories, mosques, museums, and planetariums. This article discusses a study on the feasibility of Islamic astrotourism in Malaysia. This article aims to enlighten the role of Islamic astronomy may significantly contribute to tourism. A qualitative method was used in this article using instrument such as document analyses, interviews and observations. The result shows that there is a tight collaboration between Islamic astronomy and tourism in some activities held by astronomical institutions and travel agencies, including of amateur astronomers and astronomical organizations such as tours, conferences, carnivals, and publications. In addition, it will show the efficiency of involvement of such organizations in the development of Islamic astrotourism in Malaysia.
COMPARISON OF INCIDENCE OF PRE-ANALYTICAL PHASE ERRORS IN OPD AND IPD SAMPLES IN A SUPER-SPECIALTY HOSPITAL: A RETROSPECTIVE STUDY
Authors:   ijar, Singh Battu Gurpreet , Singh Battu Amitoj , Sidhu Sumeet
Published: December 2020

Objective: To evaluate and compare the incidence of errors in pre-analytical phase in OPD and IPD samples. Multitude of human involvement in preanalytical processes makes this phase error prone. Analysis of the same can help in assessing the magnitude and planning the corrective steps. Methodology: Study was conducted retrospectively for the period July 2019 to June 2020. Samples collected from OPD sample collection room and different areas of IPD were scrutinized for pre-defined errors. Number of errors in OPD and IPD were statistically compared. Results: 679 samples out of 50713 (1.3%) OPD samples in the study period had one error or the other. Similarly, 1533 samples out of 87525 (1.7%) IPD samples had errors. When compared statistically, this difference is highly significant. (p < 0.00001). Conclusion: IPD samples are more prone to errors for the fact that these samples are collected by nursing staff or resident doctors in the different areas of the hospital. This staff is involved in patient care and has to look after multiple tasks, hence chances of error are more. OPD samples are collected by the same team, who are trained phlebotomists and are in constant touch with lab. Thus OPD samples have less preanalytical phase errors.
LESCH NYHAN SYNDROME- UNUSUAL PRESENTATION- A CASE REPORT
Authors:   ijar, Singh Deepti , Pandey Shalini , Jha Avinash
Published: December 2020

Lesch Nyhan Syndrome (LNS) is a rare hereditary disorder with an incidence of 1 in 380,000. It is a condition characterized by neurological and behavioral abnormalities and uric acid over production in the body. The authors here report a case where developmental delay, a common presentation was complicated by presence of pathological jaundice in neonatal period. It was further complicated by parents shifting to another country and lost to follow up. By the time case was diagnosed and parental counseling was done, mother was already pregnant and 20 weeks into her 2nd pregnancy and abortions were prohibited by law in that country. It is unfortunate that 2nd child is also a male child who is affected.
INNOVATIVE ASPECTS OF THE DEVELOPMENT OF THE TOURISM INDUSTRY IN A NEW STAGE OF DEVELOPMENT OF UZBEKISTAN
Authors:   Head of the Department of the Joint International Educational Program of the Tashkent State Economic University.100003, Tashkent, st. Islam Karimov 49,building 1., Bakhtiyor Vasievich Nasimov
Published: December 2020

The article examines topical issues of tourism development in Uzbekistan at the present stage. The author emphasizes the need for an innovative approach to the study of tourism problems. In the context of a new stage in the development of society in the country, a lot of work has been done to improve the innovative foundations of tourism. In the conditions of deepening market economic relations, highly qualified personnel play an important role in the development of tourism.
APOSTASY: IS IT HUMAN RIGHTS OR/AND FREEDOM OF RELIGION?
Authors:   Centre for Core Studies, Universiti Sains Islam Malaysia,71800 Bandar Baru Nilai, Negeri Sembilan, Malaysia., Sulaiman Adibah ,   Faculty of Major Languages, Universiti Sains Islam Malaysia, 71800 Bandar Baru Nilai, Negeri Sembilan, Malaysia., Yazid Ahmad Md ,   Research Centre for Sharia, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Azmir Mohd Nizah Mohd ,   Centre for Core Studies, Universiti Sains Islam Malaysia,71800 Bandar Baru Nilai, Negeri Sembilan, Malaysia.,   Faculty of Leadership and Management, Universiti Sains Islam Malaysia, 71800 Bandar Baru Nilai, Negeri Sembilan, Malaysia., Azraai Jamsari Ezad ,   Research Centre for Arabic Language and Islamic Civilization, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.
Published: December 2020

This study investigates the issue of apostasy or riddahor as a human right to freedom of religion or belief, especially among the Muslims. The purpose is to examine the question of whether apostasy should be recognized by modern Muslim states and societies as a human right that must be guaranteed for their citizens. Or, should it strictly be denied, thus freedom of religion or belief should not be extended to apostasy for Muslims and Muslim converts? The method used to complete the study is historical research and content analysis. This study showed that the call for recognition of apostasy as a human right is indeed influenced by the West which extremely enjoys freedom of belief or religion. As for Islam, apostasy is indeed contradictory with its teachings. This article is meaningful as it highlights the Universal Islamic Declaration of Human Rights (UIDHR) which speaks on religious freedom with limitations. UIDHR invariably attempts to match the Universal Declaration of Human Rights (UDHR) that recognizes the right to believe in whatever men want or to change their religion as they wish, at any time.
EVOLUTION, ADAPTIVE STRESSORS AND MOLECULAR HYDROGEN
Authors:   Drink HRW., T. Tarnava Alex ,   Natural Wellness Now Health Products Inc Unit C 60 Braid St, New Westminster, BC, Canada.
Published: December 2020

Molecular hydrogen (H2) has demonstrated therapeutic properties across numerous models. To date, the mechanism underlying the beneficial responses toH2 exposure remains elusive. The initial hypothesis that molecular hydrogen acts as a direct, selective antioxidant in vivodoes not reconcile models where H2 has shown to increase oxidative stress, nor does it explain numerous other physiological changes that have been observed throughout the literature. Some researchers have proposed that H2acts as ahormetic stress. This hypothesisdoes not reconcile H2 being non-toxic in nature, even at high doses. Hormeticstressors have contributedto evolutionary adaptations, with the absence of these stressors causing cellular dysfunction.H2 has played an intimate role in the evolution of our planets atmosphere, the evolution of mitochondria andof life on the planet.Endogenously produced H2 volumes vary dramatically between individuals and are expected to have varied through human evolution.Our cells have evolved to tolerate erratic and intermittent exposure to H2. Intermittent exogenous H2exposure yields results similar to various hormetic stressors. Continued research elucidating how H2 acts as an adaptive stressor, both through endogenous levels and exogenous supplementation, are highly warranted.
TRICHOMONAS VAGINALIS PROSTATITIS: UNUSUAL MODE OF DISCLOSURE OF COVID-19 (A CASE REPORT)
Authors:   Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco., Heddat Abdeljalil , Moussaoui Mohamed ,   Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco., Elkettani Chafik ,   Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco., Rabii Redouane ,   Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
Published: December 2020

A new coronavirus outbreak has started since December 31, 2019. COVID-19 can cause multi-systemic infections of which respiratory complications are the most obvious symptoms. In this report, we will describe, for the first time, an unusual mode of disclosure of COVID-19 in a patient with symptoms of acute prostatitis, initially treated with antibiotic therapy and alpha-blocker. Faced with the worsening of the clinical picture and the appearance of respiratory signs in our current pandemic context, the search for corona virus by PCR on nasopharyngeal sample was carried out and proved positive in our patient.
IMPACT OF COVID-19 ON THE SEXUALITY OF A SAMPLE OF MOROCCAN PATIENTS RECOVERED FROM THE CORONA VIRUS
Authors:   Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco., Heddat Abdeljalil , Houry Younes ,   Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco., Elomri Ghassane ,   Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco., Rabii Redoune ,   Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
Published: December 2020

Since December 2019, the COVID-19 pandemic has known a rapid and distressing spread. Little is known about the sexual impact on infected patients. However, several studies have reported a significant psychological impact on the population.The objective of our study is to assess the impact of the COVID19 pandemic on the sexuality of individuals who have been infected with the virus.Our study focuses on a population of 50 Moroccan patients initially declared to have COVID-19, using a multiple choice questionnaire on sexuality before and after infection with the virus. All participants were part of a couple in which at least one of the two partners had been infected with SARS-CoV-2.The results showed that all subjects were sexually active before their infection, of which 20% were dissatisfied with their sex life. At the time of our study, 78% of the recovered patients had not resumed sexual activity. 60% said they were anxious about having sex and 81% said the pandemic had altered their sex life. Only one patient reports an increase in libido and an improvement in the quality of orgasm. A couple reported having resumed sexual activity but with a change in their relationships.Anxiety and fear of infecting the other are major concerns, which affect the resumption of normal sexual activity and which sometimes lead to a change in sexual practices.
COMPARISON OF THE EFFECT OF ULTRASOUND VERSUS LASER ON PAIN AND FUNCTION IN SUBJECTS WITH OSTEOARTHRITIS KNEE
Authors:   Intern, SBB College of Physiotherapy, Ahmedabad, India., Shah Apurva , Sheth Megha ,   Lecturer, SBB College of Physiotherapy, Ahmedabad, India., Shah Deep ,   Intern, SBB College of Physiotherapy, Ahmedabad, India.
Published: December 2020

Background:Osteoarthritis(OA) is a degenerative joint disease which leads to loss of hyaline articular cartilage associated with underlying bony changes. Knee osteoarthritis(KOA) is associated with pain and functional impairment which negatively affects the patients quality of life. Ultrasound and LASER have been found effective in KOA but studies comparing the two are less. Method:An experimental study was conducted with 21 patients of unilateral KOA randomized into three groups. Each group had 7 patients. Group A- Ultrasound- 1MHz, Pulsed1:1, 0.8W/cm2, 10 min on medial knee joint line. Group B- LASER- 7.6J for 1 min and 30 sec for each trigger point. Group C-Conventional physiotherapy. All subjects received conventional physical therapy with hot packs and quadriceps exercise of affected knee. Outcome measures used were Numerical pain rating scale(NPRS), Sit to stand(STS) and Timed up and go test(TUG). Result:Using Wilcoxon test, mean difference in painin Group A(W=-2.414,p=0.016), GroupB(W=-2.460,p=0.014 ), GroupC(W=-2.392 ,p=0.017). Mean difference in STS in GroupA(W=-2.392,p=0.017 ), Group B(W=-2.392,p=0.017 ), Group C(W=-2.428,p=0.015). Mean difference in TUG, Group A(W=-2.366,p=0.018),GroupB(W=-2.371,p=0.018 ) Group C(W=-2.375 ,p=0.018 ). Applying Kruskal-Wallis test, mean difference between the groups, for pain(KW=6.612,p=0.037), STS(KW=3.020,p=0.221) and TUG(KW=7.822,p=0.020). Applying Bonferronis post hoc test mean difference in pain between groups Aand B was statistically significant(p=0.03), and mean difference in TUG between groups Band C was statistically significant(p=0.013). Conclusion:Ultrasound,LASER and conventional physiotherapy are effective in reducing pain, improving function and mobility in subjects with OA knee. LASER is more effective than ultrasound and conventional PT for pain and more effective than conventional PT for mobility.
PHARMACOPOEIAL AND HPTLC FINGERPRINT STUDIES OF DARCHINI Ã‚Â– ANIMMUNITY BOOSTER UNANI SINGLE DRUG
Authors:   Central Council for Research in Unani Medicine, Janakpuri, New Delhi., R.P. Meena , Asim Ali Khan ,   Central Council for Research in Unani Medicine, Janakpuri, New Delhi., S Subhani ,   Central Council for Research in Unani Medicine, Janakpuri, New Delhi., a Mustehasan ,   Central Council for Research in Unani Medicine, Janakpuri, New Delhi., NMA Rashid ,   National Research institute of Unani Medicine for Skin Disorders, Hyderabad., A Siddiqui ,   National Research institute of Unani Medicine for Skin Disorders, Hyderabad., J Imam ,   National Research institute of Unani Medicine for Skin Disorders, Hyderabad.
Published: December 2020

Corona virus disease 2019 (COVID-19) is threatening the worldwide population by causing symptoms like fever, cough, shortness of breathand tirednessetc.A huge population of world is suffering from this disease and no specific vaccine for this pandemic disease has been developed. According to the guidelines of Ministry of AYUSH, this disease can be prevented by taking immunity boosters, as immune system plays a vital role in defence against any disease. In Unani system of medicines, many drugs of plant origin are mentioned in classical literature for strengthening and increasing the immunity of humans. Darchini is one of the potent immune boosters and it is believed that consumption of Darchini decoction with honey strengthens the immune system.The Ministry of AYUSH, Govt. of India in its Advisory has considered Darchini as one of the important ingredient of AYUSH Joshanda/ Kwath/ Kudineer.Since, the drug Darchini is being given to COVID-19 patients as prophylaxis regime, it has become necessary to authenticate and develop its pharmacopoeial standards so that quality raw material can be provided to needy mass. The present study is aimed to develop identity, purity and strength of drug using pharmacognostical, physico-chemical and quality control methods.
COLLABORATIVE GOVERNANCE IN IMPLEMENTATION NATIONAL HEALTH INSURANCE PROGRAM IN BANDUNG CITY
Authors:   PhD Student, Department of Public Administration,Universitas Diponegoro Semarang, Indonesia., M.Si. Susniwati, , M.Si. Sri Suwitri, ,   Professor, Department of Public Administration,UniversitasTidar Magelang, Indonesia., Larasati , M.S. Endang ,   Professor, Department of Public Administration,Universitas Diponegoro Semarang, Indonesia., Purnaweni , M.Si Hartuti ,   Lecturer, Department of Public Administration,Universitas Diponegoro Semarang, Indonesia.
Published: December 2020

Bandung is one of 4 (four) districts in West Java that have received Universal Health Coverage (UHC) with more than 95% participation as of January 1, 2018. In the implementation of the JKN program in Bandung, there are still some obstacles, namely collaboration between the main actors of the program has not been implemented and the lack of information socialization to the community. The purpose of this article is to analyze collaborative governance in the implementation of the JKN program in Bandung. The research method used is a descriptive method with a qualitative approach. Data collection techniques using observation, in-depth interviews, and documentation study. The results of research on collaborative governance in the implementation of the JKN program in Bandung on the dimensions of the context system that houses the JKN Program in Bandung. The implementation of the JKN program in Bandung requires improving accountability function and role sharing between various sectors involved. The dimensions of the collaborative governance regime consist of the dynamics of collaboration and collaboration action between the relevant stack holders. Collaboration between stakeholders has not been optimal, there is still a lot of obscurity in the data request process. Collaboration between stakeholders is difficult due to the fragmentation of national, regional, and health systems. The third dimension of collaboration dynamics consisting of 3 (three) components namely principle engagement, shared motivation, and capacity for joint action needs to improve information socialization so that the equalization of health services through the JKN program can be implemented to the maximum.
PARAMETER ANALYSIS SO42-, CL-, FE, CD, PO4, NO3, PB, AND ZNON THE WATER LAKE DUMA GALELA, NORTH HALMAHERA DISTRICT
Authors:   Chemistry Education Department of Universitas Khairun,Ternate 97721 North Maluku - Indonesia., Zam Zam Zulkifli , Umar Sudir ,   Chemistry Education Department of Universitas Khairun,Ternate 97721 North Maluku - Indonesia., Aulia Rahman Nurul ,   Chemistry Education Department of Universitas Khairun,Ternate 97721 North Maluku - Indonesia., Muin Fadlan ,   Chemistry Education Department of Universitas Khairun,Ternate 97721 North Maluku - Indonesia.
Published: December 2020

This research conducted to measure the chemical parameters and estimate the carrying capacity of the environmentof lake Duma GalelaNorth Halmahera Utara. The air quality test uses the Air Quality Index approach that is unbeatable with PP. 82 of 2001. The results showed Lake Duma TSS levels at TS-1 26.5 mg/L, TS-2 23.8 mg/L, TS-3 21.7 mg/Land TS-4 24.9 mg/L. The value of Chemical Oxygen Demand (COD) averaged 3-4 mg/L. The Dissolved Oxygen (DO) value was between 5.3-6.7mg/L. Sulfate TS-1 11.63 mg/L, TS-2 12.15 mg/L, TS-3 11.52 mg/Land TS-4 11.23 mg/L. Chloride ion (Cl-) TS-1 23.46 mg/L, TS-2 23.16 mg/L, TS-3 23.41 mg/Land TS-4 21.86 mg/L. Iron (Fe) TS-1 0.0472 mg/L, TS-2 0.0516 mg/L, TS-3 0.0608 mg/L and TS-4 0.0434 mg/L. Cadmium (Cd) TS-1 0.007 mg/L,TS-2 0.007 mg/L, TS-3 ND and TS-4 0.009 mg/L. Nitrate between 0.0063-0.23 mg/L . Lead (Pb) TS-1 0.03 mg/L , TS-2 0.02 mg/L, TS-3 0.04 mg/Land TS-4 0.06 mg/L, Zn TS-1 0.01 mg/L, TS-2 0.02 mg/L, TS-3 0.03 mg/L, and TS-4 0.01 mg/L. Thus, lake Duma is in a good condition for use in fish farming to support the communitys economy.
PEDIATRIC BILATERAL ENDOGENOUS ENDOPHTHALMITIS POST MENINGITIS: A CASE REPORT WITH LITERATURE REVIEW
Authors:   Ophthalmology B department CHU avicenne of Rabat, Morocco. Mohammed V university of Rabat., Jouidi Wafae , Mrad Khalil ,   Ophthalmology B department CHU avicenne of Rabat, Morocco. Mohammed V university of Rabat., Naya Kaoutar ,   Ophthalmology B department CHU avicenne of Rabat, Morocco. Mohammed V university of Rabat., Abdellah Elhassan ,   Ophthalmology B department CHU avicenne of Rabat, Morocco. Mohammed V university of Rabat., Berraho Amina ,   Ophthalmology B department CHU avicenne of Rabat, Morocco. Mohammed V university of Rabat.
Published: December 2020

Pediatric endogenous endophthalmitis is a rare disease that can cause serious ophthalmic damage. We report and discuss the diagnostic aspects and the clinical outcome of pediatric endogenous endophthalmitisdue to bacterial meningitis in a immunocompetent 3 year old infant with a three days history of, photophobia, purulent discharge, redness, corneal edema, hypopyon, poor red reflex and nausea.His parents brought him to our emergency department. He was diagnosed as having bilateral endogenous endophthalmitis associated with bacterial meningitis.Intravenous broad-spectrum antibiotic therapy was initiated with Cefotaxime 200 mg / kg per day in 4 slow IV injections and vancomycin15mg/kg per day in 4 IV injections. Intravitreal antibiotic (vancomycin and ceftazidime) injections were performed in both eyes. Two weeks post presentation, the best-corrected visual acuity in both eyes improved to 0.4, and inflammation of the anterior chamber and vitreous cavity was decreased. We recommend that when endogenous endophthalmitis is suspected along with meningitis, or if it is known to be present, Intravitreal and intravenous antibiotics should be promptly administered to preserve vision.