bluuebunny/crossref_metadata_2025 huggingface dataset:
A Hybrid Attention-based Deep Model for Lung Cancer Subtype Classification from Multimodality Images
Authors: Jacob Chinnu , Menon Gopakumar C.
Published: June 2023

Lung cancer is a deadly type of malignancy that poses a significant threat to human health. Accurately identifying the subtypes of lung cancer is critical for effective treatment. However, conventional methods for determining subtypes, such as histological examination, are invasive and time-consuming. In order to overcome this problem, a non-invasive approach for predicting lung cancer subtypes using multi-modality images with a hybrid model is proposed in this study. The model combines attention-based Convolutional Neural Networks (CNNs) and machine learning classifiers to achieve this objective. The model employs a soft-attention mechanism to focus on the pathological areas and extract both global and local features from the images. The stack-based ensemble classifier employs logistic regression as a meta-learner and four machine learning classifiers, including Support Vector Machine (SVM), Naive Bayes, Random Forest, and J48. The classifier categorizes lung cancer into Adenocarcinoma (ADC), Squamous Cell Carcinoma (SQC), and Small Cell Carcinoma (SCC). The suggested model validated using publically accessible datasets (Lung-PET-CT-DX, Lung1, and Lung3) achieved superior performance, with a validation accuracy of 98.8%, an F1-score of 0.986, and a Matthews Correlation Coefficient (MCC) of 0.988.
Learning Polarity Embedding Attention for Aspect-based Sentiment Analysis
Authors: Wadawadagi Ramesh , Hatture Sanjeevakumar M. , Pagi Veerappa
Published: June 2023

The primary goal of Sentiment Analysis (SA) is to recognize the emotions present in natural language text. Generally, in opinion content, emotions are often driven by several aspects of their interests. Any SA task that groups data into various aspects and identifies sentiments is referred to as Aspect-Based Sentiment Analysis (ABSA). Recent advances in Deep Learning (DL) have brought revolutionary changes in the performance of Machine Learning models. Their ability to capture semantic and syntactic traits of any intrinsic data model is highly appreciated. In this research work, we use DL techniques to address the challenges of ABSA aiming to improve sentiment granularity at the aspect level. The proposed methodology works in two stages: (i) aspect terms extraction and (ii) sentiment polarity classification. The task of aspect terms extraction is achieved through the concept of Named-Entity Recognition (NER). However, most of the available NER models are domain dependent and utilize hand-crafted features for learning labeled data. Hence, for aspect terms extraction, a joint model based on Bi-GRU and Conditional Random Fields (CRF) is proposed. Similarly, for sentiment polarity classification, we introduce a novel attention-based neural network called Polarity Embedded Attention Network (PEAN). The intuition behind the PEAN is that, when an aspect term appears in a sentence, its related sentiment term is represented by the polarity embedding. Hence, PEAN combines sentence embedding with aspect and polarity embedding to learn the relationship between sentence and aspect terms. The effectiveness of the proposed model is realized through a comparative study of different models on benchmark datasets. It yields better results compared to other baseline techniques.
The Prospects of Quantum Secure Direct Communication: An Overview
Authors: Chou Yao-Hsin , Tseng Kuo-Chun , Kuo Shu-Yu
Published: June 2023

Quantum-secure communication and computation have garnered increasing attention due to their powerful search capabilities for certain complex problems and their ability to provide unconditional security. This indicates that classical cryptography, such as asymmetric ciphers based on complex mathematics, faces a significant threat from quantum algorithms. However, quantum cryptography can detect any attempt to eavesdrop on a channel. As a result, the investigation and implementation of quantum computers and quantum-secure communication networks have become essential objectives for numerous research teams. This paper provides an overview of quantum cryptography, including its development, and focuses on the theoretical aspect of quantum secure direct communication (QSDC). This helps readers understand the theoretical operating principles and gain a better understanding of the entire quantum characteristic and protocol operation in the QSDC field. QSDC enables secure communication without previously shared private keys, making it a crucial topic in quantum cryptography research. This paper provides an overview of several well-known versions of QSDC in theory, discussing their applications, challenges and potential future directions.
The Milwaukee Formation (Givetian, Wisconsin): gone but not forgotten
Authors: Gass Kenneth C.
Published: June 2023

The Milwaukee Formation, a sequence of Givetian (Middle Devonian) marine strata deposited in what is now southeastern Wisconsin, USA, was recognized as preserving an exceptionally diverse biota of invertebrates, placoderms, and plants, when local cement companies mined the rock for the manufacture of hydraulic cement from 1876 to 1911. It is now recognized as containing one of North America's most diverse biotas of its age coming from a single formation, having roughly 250 species, 100 families, 16 phyla, and four kingdoms. Intense collecting has revealed the rich biodiversity that prevailed during the Devonian Period in what is now the Milwaukee area. When the cement mines shut down, the quarries were filled and what was already regarded as a localized series of outcrops became even more restricted. Today the formation is known almost exclusively from limited exposures in Estabrook Park and the adjoining Lincoln Park, in Milwaukee County, in the area once occupied by the cement quarries. These outcrops (the type locality) are protected by a Milwaukee County Park Ordinance that prohibits removing materials from the parks, thus enabling the type locality to remain intact for educational and non-destructive research purposes, while largely unstudied museum collections remain available for ongoing research.
The ‘Coal Measures’ of Grand Ledge, Michigan, USA
Authors: Brandt Danita S. , Velbel Michael A.
Published: June 2023

The best-exposed natural bedrock outcrops in Michigan's southern peninsula are Upper Carboniferous (Pennsylvanian) sandstone ledges underlain by silts, clays, and coals in classic midcontinent ‘cyclothem’ stratigraphy, exposed along the Grand River in the city of Grand Ledge. Native Americans used the underclay in pottery; later commercial mining was the basis for clay-products factories. In the 1800s, the ledges provided a picturesque setting for a resort economy. Among the beneficiaries of repurposed quarries (now parks) are generations of Michigan geoscience students. A trip to Grand Ledge is often the first geology field experience for many students and plays an important role in the professional development of practising geoscientists and geoscience educators in Michigan. After an announcement of plans to expand the city's water treatment plant, adjacent to the cyclothem exposure, geologists from academia, government, and industry united to support preservation of the outcrops. City officials, previously unaware of the geoheritage value of the rocks exposed in their parks, are willing to work with geoscientists to preserve the site. This experience underscored the importance of documenting the geoheritage of the Grand Ledge area and establishing relationships with those who have oversight of these ‘greatest outcrops’ to ensure their preservation for future generations.
The Maastrichtian type area (Netherlands–Belgium): a synthesis of 250+ years of collecting and ongoing progress in Upper Cretaceous stratigraphy and palaeontology
Authors: Jagt John W. M. , Claessens Leon P. A. M. , Fraaije René H. B. , Jagt-Yazykova Elena A. , Mulder Eric W. A. , Schulp Anne S. , Wallaard Jonathan J. W.
Published: June 2023

Cretaceous limestones near Maastricht (SE Netherlands) have been quarried at least since Roman times. In the late eighteenth century, scientific interest developed in their macrofossil content and specimens were illustrated for the first time. Amongst the early discoveries was a partial skull of a large predatory vertebrate that would play an important role in the emergence of modern palaeontology and our understanding of the concept of extinction. After decades of scientific debate, this animal was recognized as a large extinct marine relative of monitor lizards (varanoids) and named
Mosasaurus.
A detailed lithostratigraphy of Upper Cretaceous (Santonian–Maastrichtian) rocks was established in the Maastrichtian type area during the mid-1970s, which resulted in a renewed interest in fossil hunting by professional and amateur palaeontologists alike. During recent decades, both micro- and macrofossils have enabled a refinement of biozonations, correlations within the basin and with sections elsewhere, a greater insight into taphonomic processes and updated taxonomic interpretations. A new age model and chemostratigraphical framework is the most recent addition, permitting the placement of geoheritage in a larger frame and intensifying outreach to the public, including also virtual and augmented reality and hands-on experience to visitors of museum and (disused) quarries alike.
Chickies Rock, a striking promontory on the Susquehanna River: the early Cambrian type locality of the trace fossil
Skolithos
and a model site for structural analysis
Authors: Thomas Roger D. K. , Driscoll Elizabeth L.
Published: June 2023

Chickies Rock rises abruptly from the east bank of the Susquehanna River at Columbia, Pennsylvania, where it breaks through a ridge held up by massively bedded quartzite. Here in the 1830s, Samuel Haldeman recognized long straight tubes that he later described as
Skolithos linearis
, penetrating the quartzite. Uncertain about the nature of these cylindrical ‘vermiform or linear’, unbranched ‘stems’, Haldeman first treated them as a subgenus of
Fucoides
, to which root-like traces were then often assigned. By the time James Hall first illustrated the species in 1847, Haldeman was sure they were burrows of a worm-like animal, as the name he had chosen implied. Since 1960, Donald Wise has developed a detailed analysis of structural deformation of the Chickies Anticline, using the
Skolithos
burrows as ‘plumb-bobs’ against which Taconic rotation of the rock fabric can be measured. Wise showed that later Alleghanian deformation produced prominent folds with external rotation up to twice as great as that of the rock fabric itself. Now conserved as a county park, Chickies Rock attracts many visitors. Its cliff-top is a superb viewpoint from which to contemplate progressive westward migration of the Appalachian drainage divide, ongoing since the late Jurassic opening of the Atlantic Ocean.
Technical Perspective for Sherman: A Write-Optimized Distributed B+Tree Index on Disaggregated Memory
Authors: Kraska Tim
Published: June 2023

Separation of compute and storage has become the defacto standard for cloud database systems. First proposed in 2007 for database systems [2], it is now widely adopted by all major cloud providers such as Amazon Redshift, Google BigQuery, and Snowflake. Separation of compute and storage adds enormous value for the customer. Users can scale storage independently of compute, which enables them to only pay for what they really uses. Consider a scenario in which data grows linearly over time, but most queries only access the last month of data, which remains relatively stable. Without the separation of compute and storage, the user would gradually be forced to significantly increase the database cluster capacity. In contrast, modern cloud database systems allow scaling the storage separately from compute; the compute cluster stays the same over time, whereas the data is stored on cheap cloud storage services, like Amazon S3.
Technical Perspective: Conjunctive Queries with Comparisons
Authors: Vansummeren Stijn
Published: June 2023

Query processing, the art of efficiently executing a relational query on a given database, is a foundational and core area in data management research. Established at the dawn of relational database systems in the 1970's, relational query processing remains a highly relevant and vibrant research topic today as recent work shows that, apart from its application in traditional database scenarios, it is also highly effective in optimizing machine learning workloads [1].
Current Trends in Anti-Aging Strategies
Authors: Rosen Robert S. , Yarmush Martin L.
Published: June 2023

The process of aging manifests from a highly interconnected network of biological cascades resulting in the degradation and breakdown of every living organism over time. This natural development increases risk for numerous diseases and can be debilitating. Academic and industrial investigators have long sought to impede, or potentially reverse, aging in the hopes of alleviating clinical burden, restoring functionality, and promoting longevity. Despite widespread investigation, identifying impactful therapeutics has been hindered by narrow experimental validation and the lack of rigorous study design. In this review, we explore the current understanding of the biological mechanisms of aging and how this understanding both informs and limits interpreting data from experimental models based on these mechanisms. We also discuss select therapeutic strategies that have yielded promising data in these model systems with potential clinical translation. Lastly, we propose a unifying approach needed to rigorously vet current and future therapeutics and guide evaluation toward efficacious therapies.
Impact of Negative Fluid Balance on Mortality and Outcome of Patients with Confirmed COVID-19
Authors: Eftekhar Seyed Parsa , Sepidarkish Mahdi , Amri Maleh Parviz , Jafaripour Iraj , Hedayati Mohammad Taghi , Amin Kamyar , Pourkia Roghayeh , Abroutan Saeid , Saravi Mehrdad , Jalali Farzad , Sadeghi Haddad Zavareh Mahmoud , Ziaie Naghmeh
Published: June 2023

Purpose. Maintaining the proper fluid balance is a fundamental step in the management of hospitalized patients. The current study evaluated the impact of negative fluid balance on outcomes of patients with confirmed COVID-19. Methods. We considered the negative fluid balance as a higher output fluid compared to the input fluid. The fluid balance was categorized into four groups (group 4: −850 to −500 ml/day; group 3: −499 to −200 ml/day, group 2: −199 to 0 ml/day, and group 1 : 1 to 1000 ml/day) and included ordinally in the model. The outcomes were all-cause mortality, length of hospitalization, and improvement in oxygen saturation. Results. The fluid balance differed significantly among nonsurvivors and survivors (MD: −317.93, 95% CI: −410.21, −225.69, and

p
<
0.001

). After adjusting for potential confounders, there was a significantly lower frequency of mortality in patients with negative fluid balance compared to the controls (aRR: 0.69, 95% CI: 0.57, 0.84, and

p
<
0.001

). Similarly, the length of hospitalization was significantly shorter in the negative fluid balance group in comparison to the control group (aMD: −1.01, 95% CI: −1.74, −0.28, and

p
=
0.006

). Conclusion. We determined that the negative fluid balance was associated with favorable outcomes in COVID-19 patients. The negative fluid balance was associated with the reduced mortality rate and length of hospitalization as well as improvement in oxygen saturation. Moreover, the NT-proBNP >781 pg/mL and fluid balance >−430 mL might be the predictors for positive fluid balance and mortality, respectively.
A Low Cross-Polarization Microstrip Antenna Array for Millimeter Wave Applications
Authors: Fu Yanzhi , Lin Yixiang , Shi Changda
Published: June 2023

A low cross-polarization microstrip antenna array for millimeter wave (mmW) applications is proposed in this paper. The antenna element is composed of symmetric T-shaped patches with vias. The adoption of a double-sided symmetric radiation patch structure can suppress the cross-polarized electric field, and the vias reduces energy leakage during the power transmission along the antenna patches. To verify the concept, a 1 × 8 antenna array is fabricated and measured. The measured −10 dB impedance of the antenna array is 28.4% (31 GHz–41.5 GHz) and the peak gain is 15 dBi. The cross polarization ratio is above 35 dB and the 3 dB beamwidths on E-plane and H-plane are 7.5° and 135°, respectively. The proposed compact size and low cross-polarization antenna array might be a good choice for phased array radar and 5th generation (5G) mobile communication applications.
Data from Plasma 25-hydroxyvitamin D levels and survival in stage III colon cancer: Findings from CALGB/SWOG 80702 (Alliance)
Authors: Wang Qiao-Li , Ma Chao , Yuan Chen , Shi Qian , Wolpin Brian M. , Zhang Yin , Fuchs Charles S. , Meyer Jeffrey , Zemla Tyler , Cheng En , Kumthekar Priya , Guthrie Katherine A. , Couture Felix , Kuebler Philip , Kumar Pankaj , Tan Benjamin , Krishnamurthi Smitha , Goldberg Richard M. , Venook Alan , Blanke Charles , Shields Anthony F. , O'Reilly Eileen M. , Meyerhardt Jeffrey A. , Ng Kimmie
Published: June 2023

Abstract
Purpose: To assess whether higher plasma 25-hydroxyvitamin D (25[OH]D) are associated with improved outcomes in colon cancer and whether circulating inflammatory cytokines mediate such association. Patients and Methods: Plasma samples were collected from 1437 patients with stage III colon cancer enrolled in a phase III randomized clinical trial (CALGB/SWOG 80702) from 2010 to 2015, who were followed until 2020. Cox regressions were used to examine associations between plasma 25(OH)D and disease-free survival (DFS), overall survival (OS), and time to recurrence (TTR). Mediation analysis was performed for circulating inflammatory biomarkers of CRP, IL-6, and sTNF-R2. Results: Vitamin D deficiency (25(OH)D<12 ng/ml) was present in 13% of total patients at baseline and in 32% of Black patients. Compared with deficiency, non-deficient vitamin D status (≥12 ng/ml) was significantly associated with improved DFS, OS and TTR (all Plog-rank<0.05), with multivariable-adjusted hazard ratios of 0.68 (95% confidence interval [CI], 0.51-0.92) for DFS, 0.57 (0.40-0.80) for OS, and 0.71 (0.52-0.98) for TTR. A U-shaped dose-response pattern was observed for DFS and OS (both Pnon-linearity<0.05). The proportion of the association with survival that was mediated by sTNF-R2 was 10.6% (P mediation=0.04) for DFS and 11.8% (P mediation=0.05) for OS, whereas CRP and IL-6 were not shown to be mediators. Plasma 25(OH)D was not associated with the occurrence of ≥ grade 2 adverse events. Conclusions: Non-deficient vitamin D is associated with improved outcomes in patients with stage III colon cancer, largely independent of circulation inflammations. A randomized trial is warranted to elucidate if adjuvant vitamin D supplementation improves patient outcomes.
A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma
Authors: Ramos Louise , Truong Sarah , Zhai Beibei , Joshi Jay , Ghaidi Fariba , Lizardo Michael M. , Shyp Taras , Kung Sonia H.Y. , Rezakhanlou Alireza M. , Oo Htoo Zarni , Adomat Hans , Le Bihan Stephane , Collins Colin , Bacha Jeffrey , Brown Dennis , Langlands John , Shen Wang , Lallous Nada , Sorensen Poul H. , Daugaard Mads
Published: June 2023

Purpose:

Histone deacetylase (HDAC) inhibition has been shown to induce pharmacologic “BRCAness” in cancer cells with proficient DNA repair activity. This provides a rationale for exploring combination treatments with HDAC and PARP inhibition in cancer types that are insensitive to single-agent PARP inhibitors (PARPi). Here, we report the concept and characterization of a novel bifunctional PARPi (kt-3283) with dual activity toward PARP1/2 and HDAC enzymes in Ewing sarcoma cells.

Experimental Design:

Inhibition of PARP1/2 and HDAC was measured using PARP1/2, HDAC activity, and PAR formation assays. Cytotoxicity was assessed by IncuCyte live cell imaging, CellTiter-Glo, and spheroid assays. Cell-cycle profiles were determined using propidium iodide staining and flow cytometry. DNA damage was examined by γH2AX expression and comet assay. Inhibition of metastatic potential by kt-3283 was evaluated via ex vivo pulmonary metastasis assay (PuMA).

Results:

Compared with FDA-approved PARP (olaparib) and HDAC (vorinostat) inhibitors, kt-3283 displayed enhanced cytotoxicity in Ewing sarcoma models. The kt-3283-induced cytotoxicity was associated with strong S and G2–M cell-cycle arrest in nanomolar concentration range and elevated DNA damage as assessed by γH2AX tracking and comet assays. In three-dimensional spheroid models of Ewing sarcoma, kt-3283 showed efficacy in lower concentrations than olaparib and vorinostat, and kt-3283 inhibited colonization of Ewing sarcoma cells in the ex vivo PuMA model.

Conclusions:

Our data demonstrate the preclinical justification for studying the benefit of dual PARP and HDAC inhibition in the treatment of Ewing sarcoma in a clinical trial and provides proof-of-concept for a bifunctional single-molecule therapeutic strategy.
Figure S3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Authors: Finlay John B. , Abi Hachem Ralph , Jang David W. , Osazuwa-Peters Nosayaba , Goldstein Bradley J.
Published: June 2023

Identical RNA expression plots to those shown in Fig. 4 A and B, but with IDH2 mutant ONB separated out from wild type tumors.
Figure S2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Authors: Finlay John B. , Abi Hachem Ralph , Jang David W. , Osazuwa-Peters Nosayaba , Goldstein Bradley J.
Published: June 2023

RNA expression signatures of ONB from Classe et al., 2018 based on markers traditionally associated with sinonasal undifferentiated carcinoma (A), small cell neuroendocrine carcinoma (B), and olfactory neuroblastoma (C), divided by control OE, low grade ONB, high grade ONB, and IDH2 mutant ONB. A) Expression of keratins is not significantly increased in IDH2 mutant ONB versus IDH2 wild type tumors. B) Small cell neuroendocrine carcinoma (SNEC) marker genes are not highly expressed ONB from Classe et al. dataset. C) Expression of canonical neuroendocrine markers is negatively associated with ONB grade, and is not significantly different between high grade IDH2 and high grade IDH2 mutant ONB.
Figure S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Authors: Finlay John B. , Abi Hachem Ralph , Jang David W. , Osazuwa-Peters Nosayaba , Goldstein Bradley J.
Published: June 2023

A and B identical to Figure 2A and B, but with the two IDH2 mutant tumors separated out from the other tumors into their own category. C shows estimated respiratory cell type proportions across normal OE, low grade, high grade, and IDH2 mutant tumors, which reveals that model estimates do not predict an increase in respiratory cell programming in IDH2 mutant tumors. The “All Respiratory lineage cells” plot includes cell type proportions from respiratory cells, respiratory basal cells, respiratory suprabasal cells, respiratory ciliated cells, and secretory cells.
FIGURE 2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Authors: Finlay John B. , Abi Hachem Ralph , Jang David W. , Osazuwa-Peters Nosayaba , Goldstein Bradley J.
Published: June 2023

Pseudodeconvolution of ONB bulk RNA-seq defines proportions of cell type–specific transcriptomics across low- and high-grade tumors. A, Stacked bar chart depicts predicted proportions of cell types in bulk tumors when mapped to control adult human olfactory mucosa using the deconvolution model. B, Statistical differences in selected ONB cellular composition, based on one-way ANOVA followed by post hoc Tukey test (*, P < 0.05; **, P < 0.01).
FIGURE 1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Authors: Finlay John B. , Abi Hachem Ralph , Jang David W. , Osazuwa-Peters Nosayaba , Goldstein Bradley J.
Published: June 2023

Schematic of the deconvolution workflow. Diagram of normal OE in the top left colored by cell identity (HBC: yellow; GBC: pink; immature OSN: blue; mature OSN: orange; Sustentacular: green; Bowman's Gland: purple; Olfactory ensheating cell:lime green in lamina propria; immune cells: round cells in lamina propria). The schematic depicts the two main inputs into the deconvolution model: a reference scRNA-seq dataset along with bulk RNA-seq data. The output is a stacked bar graph with estimated proportions of cell identity per bulk RNA-seq sample.
Supplementary Table 2 from A Mendelian Randomization Analysis of 55 Genetically Predicted Metabolic Traits with Breast Cancer Survival Outcomes in the Pathways Study
Authors: Fiorica Peter N. , Sheng Haiyang , Zhu Qianqian , Roh Janise M , Laurent Cecile A. , Ergas Isaac J , Delmerico Jennifer , Kwan Marilyn L , Kushi Lawrence H , Ambrosone Christine B , Yao Song
Published: June 2023

Statistically-significant findings from analysis of 2,696 White individuals
Supplementary Table 1 from A Mendelian Randomization Analysis of 55 Genetically Predicted Metabolic Traits with Breast Cancer Survival Outcomes in the Pathways Study
Authors: Fiorica Peter N. , Sheng Haiyang , Zhu Qianqian , Roh Janise M , Laurent Cecile A. , Ergas Isaac J , Delmerico Jennifer , Kwan Marilyn L , Kushi Lawrence H , Ambrosone Christine B , Yao Song
Published: June 2023

Polygenic score models pulled from the polygenic score catalog
Data from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Authors: Finlay John B. , Abi Hachem Ralph , Jang David W. , Osazuwa-Peters Nosayaba , Goldstein Bradley J.
Published: June 2023

Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Because of the low incidence of this tumor, as well as an absence of established cell lines and murine models, understanding the mechanisms driving olfactory neuroblastoma pathobiology has been challenging. Here, we sought to apply advances from research on the human olfactory epithelial neurogenic niche, along with new biocomputational approaches, to better understand the cellular and molecular factors in low- and high-grade olfactory neuroblastoma and how specific transcriptomic markers may predict prognosis. We analyzed a total of 19 olfactory neuroblastoma samples with available bulk RNA-sequencing and survival data, along with 10 samples from normal olfactory epithelium. A bulk RNA-sequencing deconvolution model identified a significant increase in globose basal cell (GBC) and CD8 T-cell identities in high-grade tumors (GBC from ∼0% to 8%, CD8 T cell from 0.7% to 2.2%), and significant decreases in mature neuronal, Bowman's gland, and olfactory ensheathing programs, in high-grade tumors (mature neuronal from 3.7% to ∼0%, Bowman's gland from 18.6% to 10.5%, olfactory ensheathing from 3.4% to 1.1%). Trajectory analysis identified potential regulatory pathways in proliferative olfactory neuroblastoma cells, including PRC2, which was validated by immunofluorescence staining. Survival analysis guided by gene expression in bulk RNA-sequencing data identified favorable prognostic markers such as SOX9, S100B, and PLP1 expression.
Significance:
Our analyses provide a basis for additional research on olfactory neuroblastoma management, as well as identification of potential new prognostic markers.
Data from A Mendelian Randomization Analysis of 55 Genetically Predicted Metabolic Traits with Breast Cancer Survival Outcomes in the Pathways Study
Authors: Fiorica Peter N. , Sheng Haiyang , Zhu Qianqian , Roh Janise M , Laurent Cecile A. , Ergas Isaac J , Delmerico Jennifer , Kwan Marilyn L , Kushi Lawrence H , Ambrosone Christine B , Yao Song
Published: June 2023

Abstract
Previous studies suggest associations of metabolic syndromes with breast cancer prognosis, yet the evidence is mixed. In recent years, the maturation of genome-wide association study findings has led to the development of polygenic scores (PGS) for many common traits, making it feasible to use Mendelian randomization to examine associations between metabolic traits and breast cancer outcomes. In the Pathways Study of 3,902 patients and a median follow-up time of 10.5 years, we adapted a Mendelian randomization approach to calculate PGS for 55 metabolic traits and tested their associations with seven survival outcomes. Multivariable Cox proportional hazards models were used to derive hazard ratios (HRs) and 95% confidence intervals (CIs) with adjustment for covariates. The highest tertile (T3)of PGS for cardiovascular disease was associated with shorter overall survival (HR=1.34, 95% CI= 1.11-1.61) and second primary cancer-free survival (HR=1.31,95% CI=1.12-1.53). PGS for hypertension (T3) was associated with shorter overall survival (HR=1.20, 95% CI=1.00-1.43), second primary cancer-free survival (HR=1.24, 95% CI=1.06-1.45), invasive disease-free survival (HR=1.18, 95% CI=1.01-1.38), and disease-free survival (HR=1.21, 95% CI=1.04-1.39). PGS for serum cystatin C levels (T3) was associated with longer disease-free survival (HR=0.82, 95% CI=0.71-0.95), breast event-free survival (HR=0.74, 95% CI=0.61-0.91), and breast cancer-specific survival (HR=0.72, 95% CI=0.54-0.95). The above associations were significant at a nominal P<0.05 level but not after correcting for multiple-testing (Bonferroni P<0.0009). Our analyses revealed notable associations of PGS for cardiovascular disease, hypertension, and cystatin C levels with breast cancer survival outcomes. These findings implicate metabolic traits in breast cancer prognosis.
O conto “Branca de Neve” e a série Once Upon a Time
Authors: Silva Francisca Elane Costa e , Silva Rafael Ferreira da , Queiroz Regina Farias de
Published: June 2023

O objetivo deste artigo é analisar algumas das estratégias usadas no processo de adaptação do conto “Branca de Neve” dos irmãos Grimm para a primeira temporada da série Once Upon a Time, disponível na plataforma de streaming Disney +, traçando semelhanças e diferenças na construção da personagem Branca de Neve. Para tanto, partiremos da comparação entre o texto televisivo e o texto literário, perpassando, ainda, por algumas versões cinematográficas e delineando elementos que caracterizam a construção da protagonista. Justifica-se a escolha do conto “Branca de Neve”, por ser o núcleo desencadeador das demais histórias da série. Analisando Hutcheon (2013) percebe-se que adaptação é um ato criativo e intertextual extensivo com a obra adaptada, que tende a se desvincular da obra de partida, formando novos sentidos e novas estruturas.
Cost-Effectiveness of Quadruple Therapy in Management of Heart Failure With Reduced Ejection Fraction in the United States
Authors: Yan Brandon W. , Spahillari Aferdita , Pandya Ankur
Published: June 2023

Background:

The 2022 clinical guidelines for management of heart failure with reduced ejection fraction call for quadruple therapy. Quadruple therapy consists of an angiotensin receptor-neprilysin inhibitor (ARNi), sodium-glucose cotransporter-2 inhibitor (SGLT2i), mineralocorticoid receptor antagonist, and beta blocker. The ARNi and sodium-glucose cotransporter-2 inhibitor are newer additions to standard of care with the ARNi replacing ACE (angiotensin-converting enzyme) inhibitors and angiotensin II receptor blockers.

Methods:

We investigate the cost-effectiveness of sequentially adding the SGLT2i and ARNi to form quadruple therapy as compared with the previous standard of care with ACE inhibitor/mineralocorticoid receptor antagonist/beta blocker. Using a 2-stage Markov model, we projected the expected lifetime discounted costs and quality-adjusted life years (QALYs) of a simulated cohort of US patients who underwent each treatment option and calculated incremental cost-effectiveness ratios. We assessed incremental cost-effectiveness ratios using criteria for health care value (<$50 000/quality-adjusted life year [QALY] indicating high-value, $50 000–150 000/QALY indicating intermediate value, and >$150 000/QALY indicating low-value) and a standard $100 000/QALY cost-effectiveness threshold.

Results:

Compared with the previous standard of care, the SGLT2i addition had an incremental cost-effectiveness ratio of $73 000/QALY and weakly dominated the ARNi addition. The addition of both the ARNi and SGLT2i for quadruple therapy offered 0.68 additional discounted QALYs over the SGLT2i addition alone at a lifetime discounted cost of $66 700, resulting in an incremental cost-effectiveness ratio of $98 500/QALY. In sensitivity analysis varying drug prices, the incremental cost-effectiveness ratio for quadruple therapy ranged from $73 500/QALY using prices available to the US Department of Veterans Affairs to $110 000/QALY using drug list prices.

Conclusions:

While quadruple therapy offers intermediate value, it is borderline cost effective compared with adding the SGLT2i alone to previous standard of care. Thus, its cost-effectiveness is sensitive to a payer’s ability to negotiate discounts off the increasing list prices for ARNI and SGLT2is. The demonstrated benefits of ARNi and SGLT2is should be weighed against their high prices in payer and policy considerations.
Shadows of the Thrown Spear: Girolamo Cardano on Anxiety, Dreams, and the Divine in Nature
Authors: Regier Jonathan
Published: June 2023

Girolamo Cardano (1501–1576), a preeminent natural philosopher, physician and astrologer of the sixteenth century, is known for the great diversity of his intellectual pursuits and writings. Across much of his work, we find an overriding concern with the dangers of human life, how those dangers might be foreseen, and how their effects can be mitigated. This essay begins by considering the epistemic significance of anxiety as it is described in his autobiography, the De propria vita. When Cardano had devoted so much effort to working out method and sense in medicine and astrology, why do episodes of foreknowledge in the autobiography seem so haphazard and disorienting? I use this question to examine Cardano’s views on the possibilities and limits of human foreknowledge, paying special attention to his treatise on dreams, the Somniorum Synesiorum libri quatuor, and his commentary on Ptolemy’s Tetrabiblos.
Cupido-Putto oder Weltmacht Eros? Der Calvinist Theobald Hock (1573–ca. 1623) wider den habsburgischen Hofkomponisten Jacob Regnart (1540–1599)
Authors: Kühlmann Wilhelm
Published: June 2023

The Calvinist politician and diplomat Theobald Hock (1573–ca. 1623) published in his collection Schönes Blumenfeld (1601) the poem “Das Cupido kein Kindt sey” (Cupid is not a child). Hitherto hardly noticed, it is a clear palinody to one of the most famous song poems of the epoch, to “Venus du und dein Kind” (Venus you and your child) written by the Kapellmeister and poet-composer Jacob Regnart († 1599) who was in Habsburg service. Both authors lived in Prague for a short time before 1599. Hock did not protest primarily against the use of pagan mythologems, as did some Christian rigorists (such as J. Rist), but (in a critical obituary of his Catholic neighbour?) Hock polemically dismisses Regnart’s text as a document of a foolish superstition that was widespread even among the educated. He replaces it with a conception of an omnipotent Eros that goes back to Hesiod and Plato, apparently mediated by rinascimental Platonism (M. Ficino), and which accompanies and drives all creations, including man’s cultural and moral achievements. Hock thus joins critical questions that the puerile figure of the naked Cupid/Amor had also provoked elsewhere (for example in the emblem book of Andreas Alciatus).
Neocolonialism and the Technopolitics of Specialization: Toward a Reimagination of the Sociotechnical Imaginaries Approach
Authors: Imbong Regletto Aldrich
Published: June 2023

As a theoretical framework in the Science and Technology Studies (sts) scholarship, the sociotechnical imaginaries approach (sta) has provided a conceptual framework and methodology that not only overcome the deterministic understanding of technological development but also theorized the relationship between society on the one hand, and science and technology on the other. However, as will be pointed out, a limitation of the sta renders it incapable of problematizing what I will call as the technopolitics of specialization, defined as the organization of unequal positions based on the capitalist centers’ control over techno-epistemic networks set against the backdrop of a neocolonial relation. Such an incapacity glosses over the persistence of neocolonialism and dependency especially in the Global South.

This paper aims to reimagine the theoretical framework of the sociotechnical imaginaries by developing a critical review of its approach. The paper will place in dialogue the most recent and relevant conceptual developments of the sta and the dependency theory of Samir Amin. The paper will present how the most relevant literature concerning the sta work on the assumption that every polity has control over existing techno-epistemic networks from which imaginaries are independently defined. The paper will argue that given the notion of international specialization developed by Samir Amin and presupposed today in the sta, the technopolitics of specialization monopolizes control of the techno-epistemic networks thereby constraining the imaginaries of peripheral countries.
A Case Study of Individual Contextual Characteristics Impact on Korean Elementary School Students’ Interest in Science Using Phase of Interest Development and the Process-Person-Context-Time Models
Authors: Choi Yoon-Sung
Published: June 2023

This study examines the individual contextual characteristics of elementary school students in Korea during the phase of interest development, using Phase of Interest Development (PIT) and Process-Person-Context-Time (PPCT) models. Four students from each level of interest development were selected to participate, and they wrote photo-journals for 12 weeks while meeting with the researcher every two weeks for semi-structured interviews. The results show that students with higher levels of interest in science tend to participate more in science activities, become more independent, and re-engage in activities. The findings suggest that factors within the microsystem, such as schoolteachers or parents, may have an influence on students’ interest in science, regardless of their level of interest. This study contributes to the theoretical foundation of interest in science research and may be useful for developing strategies to increase students’ interest in science.
The Roles of Chaos Seeding and Multiple Perturbations in Convection-Permitting Ensemble Forecasting over Southern China
Authors: Wang Jingzhuo , Chen Jing , Li Hongqi , Xue Haile , Xu Zhizhen
Published: June 2023

The roles of chaos seeding and multiple perturbations, including model perturbations and topographic perturbations, in convection-permitting ensemble forecasting, are assessed. Six comparison experiments were conducted for 14 heavy rainfall events over southern China. Chaos seeding was run as a benchmark experiment to compare their effects to the intended perturbations. The results first reveal the chaos seeding phenomenon. That is, the tiny and local perturbations of the skin soil moisture propagate into the whole analysis domain within an hour and expand to every prognostic variable, and the perturbations derived from chaos seeding develop when moist convection is active. Second, the chaos seeding has a statistically significant difference from our intended perturbations for the ensemble spread magnitudes of precipitation and the spread–skill relationships and probabilistic forecast skills of dynamical variables. Additionally, for the probabilistic forecasts of precipitation, initial and lateral boundary perturbations and model perturbations can yield statistically larger FSS and AROC scores than chaos seeding; topographic perturbations can only improve FSS and AROC scores a little. The different performances may be related to the different degrees of the real dynamical influence of our intended perturbations. Finally, model perturbations can increase the ensemble spreads of precipitation, and improve FSS and AROC scores of precipitation and the consistency of mid- and low-level dynamical variables. However, the effects of topographic perturbations are small.
Intensity-Dependent Influence of Interoceptive Accuracy on Psychophysiological Responses During Aerobic Exercise in Physically Inactive Men
Authors: Farias-Junior Luiz Fernando , Machado Daniel Gomes da Silva , Agrícola Pedro Moraes Dutra , do Nascimento Paulo Henrique Duarte , Elsangedy Hassan Mohamed , Okano Alexandre Hideki , de Sousa Maria Bernardete Cordeiro
Published: June 2023

We aimed to investigate the influence of interoceptive accuracy on affective valence, arousal, and ratings of perceived exertion (RPE) during 20 minutes of aerobic exercise at both moderate and heavy intensity among physically inactive men. We divided our participant sample into men with poor heartbeat perception (PHP, n = 13) and good heartbeat perception (GHP, n = 15), based on their cardioceptive accuracy. We measured their heart rate reserve (%HRreserve), perceived affective valence (Feeling Scale; +5/-5), perceived arousal (Felt Arousal Scale, 0–6), and ratings of perceived effort (RPE; Borg scale 6–20) every five minutes during an exercise session on a bicycle ergometer. During moderate-intensity aerobic exercise, the GHP group presented a greater decline in affective valence ( p = 0.010; d = 1.06) and a greater increase in RPE ( p = 0.004; d = 1.20) compared to the PHP group, with no group differences in %HRreserve ( p = 0.590) and arousal ( p = 0.629). Psychophysiological and physiological responses to the heavy-intensity aerobic exercise were not different between groups. We concluded that the influence of interoceptive accuracy on psychophysiological responses during submaximal fixed-intensity aerobic exercise was intensity-dependent in these physically inactive men.
An analysis of interview strategies in high-stakes crime investigations in the UK: Are they fit for purpose?
Authors: Vaughan Martin , Milne Rebecca , Dalton Gary
Published: June 2023

Providing strategic advice to the Senior Investigating Officer is a key element of the role of the Interview Manager in high-stakes crime investigations. However, no actual evaluation of such strategies has been undertaken. This exploratory study examined 15 interview strategies from three UK police forces in connection with high-stakes crime investigations. Overall, the analysis illustrated that the strategies were poorly designed, vague and lacked a cohesive structure. The study has provided an invaluable first insight into strategy design and implementation in the investigative interviewing arena. More research is required to focus on design and implementation of interview strategies.
Effects of weave structure and water-repellent compositions’ formulation on the hydrophobicity property of cotton fabric
Authors: Kaldybayeva Gulbuston Y , Nabieva Iroda A , Kaldybayev Rashid T , Nabiev Nobijon D , Nurkulov Fayzulla N , Yeldiyar Gulzinat K
Published: June 2023

Hydrophobization is one of the most common types of final finishing of textile materials for special purposes. In recent years, in this connection, the attention of researchers has been focused on the development and production of hydrophobic materials of a new generation. Obtaining hydrophobic materials necessitates the creation of new highly effective chemical preparations, increasing the heterogeneity of the material surface. To solve this problem, in this paper, we studied the dependence of the hydrophobicity of a textile material on the surface structure of the fabric and the type of water-repellent composition based on polymers. The processing of various relief structure fabrics with water-repellent compositions was carried out using the padding method. The combined action of the relief structure of the fabric surface obtained by weaving and low surface energy imparted by water-repellent compositions ensures the hydrophobicity of the textile material. The water-repellent property stability is achieved by heat treatment of padded samples at a temperature of 150–160°C for 6–7 minutes. Studies of the processing stability showed the preservation of a sufficiently high hydrophobicity after five washes.
Mechanical behaviors of cementations matrix composites reinforced with basalt weft-knitted spacer fabric under low-velocity impact
Authors: Liu Shuai , Ma Xiaotao , Ma Yuntong , Lin Haitao , Ma Pibo
Published: June 2023

The attention of this paper is focused on the impact resistance behavior and reinforcing mechanism of cement-based composites reinforced with weft-knitted spacer fabrics (FKRCs). Composites were manufactured with basalt spacer fabrics and calcium sulfoaluminate cement, both of which are eco-friendly materials. Three kinds of FKRCs with varying needle span distances of the spacer fabrics were compared with plain concrete and concrete reinforced with basalt fibers via a static-bursting test and low-velocity impact test. In addition, the failure morphologies of damaged specimens were analyzed. The experimental results revealed that the basalt spacer fabric was able to obviously enhance the impact resistance and energy absorption capacity of the concrete, while the reinforcing effect of basalt fibers was relatively restricted. In addition, spacer fabrics played a crucial role in retarding the crack generation and propagation in the cement matrix by the textile bridging effect. Furthermore, FKRCs were more sensitive to dynamic impact load, exhibiting a higher maximum peak load but lower maximum displacement. With the increase of span distances, the impact resistance of the specimens was enhanced with higher maximum impact load and energy absorption, and the brittleness of plain concrete was improved. In addition, the spacer yarn structure exhibited considerable effects on the impact behavior of the composites rather than basalt spacer fabrics. Therefore, the FKRC is suitable for structural components that require higher impact resistance in engineering applications.
Validity and Reliability of the CarGOQoL Questionnaire Among Informal Caregivers of Patients With Cancer
Authors: Ko Eun , Kim Hye Young , Bae Woo Kyun , Hwang Jun-Eul
Published: June 2023

The 29-item CareGiver Oncology Quality of Life (CarGOQoL) scale measures quality of life (QoL) based on the specific characteristics of informal caregivers of patients with cancer. The 29-item CarGOQoL has been translated to numerous other languages and validated, thus confirming its validation. This study aimed to evaluate the reliability and validity of the Korean version of the 29-item CarGOQoL. We recruited 316 informal caregivers of patients with cancer. Data were collected using structured questionnaires between January 23, 2019 and November 30, 2019, and analyzed using SPSS 27.0 and Amos 23.0. Internal consistency, construct validity, convergent and discriminant validity of the items, criterion validity, and known-group validity were tested. The 10-factor model was validated by a confirmatory factor analysis (χ2 = 687.633; P < .001; normed χ2 = 2.084; comparative fit index = .922; Tucker–Lewis index = .904; standardized root mean square residual = .050; root mean square error of approximation = .059). Criterion validity was demonstrated using the World Health Organization Quality of Life instrument-short version ( r = .495-607), visual analog scale (VAS) for QoL ( r = .509), and VAS for burden ( r = −.457). The 29-item Korean version of the CarGOQoL had known-group validity according to the Eastern Cooperative Oncology Group performance status of the patients. Cronbach’s alpha coefficient for the total scale was .90. The 29-item Korean version of the CarGOQoL demonstrated acceptable validity and reliability for measuring QoL among Korean informal caregivers of patients with cancer. The 29-item Korean version of the CarGOQoL scale can be useful in Korean oncology clinical practice and research when assessing the quality of life of informal caregivers of patients with cancer.