bluuebunny/crossref_metadata_2025 huggingface dataset:
Roles of Health Literacy in Relation to Social Determinants of Health and Recommendations for Informatics-Based Interventions: Systematic Review
Authors: Bindhu Shwetha , Nattam Anunita , Xu Catherine , Vithala Tripura , Grant Tiffany , Dariotis Jacinda K , Liu Hexuan , Wu Danny T Y
Published: January 2024

Background

Health literacy (HL) is the ability to make informed decisions using health information. As health data and information availability increase due to online clinic notes and patient portals, it is important to understand how HL relates to social determinants of health (SDoH) and the place of informatics in mitigating disparities.

Objective

This systematic literature review aims to examine the role of HL in interactions with SDoH and to identify feasible HL-based interventions that address low patient understanding of health information to improve clinic note-sharing efficacy.

Methods

The review examined 2 databases, Scopus and PubMed, for English-language articles relating to HL and SDoH. We conducted a quantitative analysis of study characteristics and qualitative synthesis to determine the roles of HL and interventions.

Results

The results (n=43) were analyzed quantitatively and qualitatively for study characteristics, the role of HL, and interventions. Most articles (n=23) noted that HL was a result of SDoH, but other articles noted that it could also be a mediator for SdoH (n=6) or a modifiable SdoH (n=14) itself.

Conclusions

The multivariable nature of HL indicates that it could form the basis for many interventions to combat low patient understandability, including 4 interventions using informatics-based solutions. HL is a crucial, multidimensional skill in supporting patient understanding of health materials. Designing interventions aimed at improving HL or addressing poor HL in patients can help increase comprehension of health information, including the information contained in clinic notes shared with patients.
Архивные документы по разминированию оккупированных территорий Калмыцкой АССР в 1943 г.
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Mandzhieva Lyubov B.
Published: January 2024

Introduction. After the liberation from the temporary occupation by the German Nazis of part of the territory of the Kalmyk ASSR in the period from August 1942, it was necessary to proceed to the restoration of the national economy, to equip the personal farms of the inhabitants of the republic. In order to do this, it was necessary to get rid of the consequences of the occupation, including clearing the land of explosive mechanisms (mines, grenades). The purpose of the article is to study the archival documents of the R-68 foundation “The Republican Commission under the Council of People’s Commissars of the KASSR to investigate the atrocities of the Nazi invaders and the damage they caused to the national economy of the Republic (1942–1943)” of the National Archive of the Republic of Kalmykia, to identify documents related to the creation of safe living conditions for the population of the republic, taking measures to mine the territory of Kalmykia. Results. The documents of the R-68 fund contain information on the neutralization of the territories of Maloderbetovsky and Sarpinsky uluses from explosive devices left from the time of military operations on them. The sources contained in the fund indicate that a significant area of the occupied territory of the uluses was mined. The absence of documents in the R-68 fund on the clearance of territories of other uluses and the city of Elista, which were temporarily occupied, does not allow us to reveal the full picture of the work carried out to neutralize the territory of the republic. At the same time, these archival documents are valuable historical sources for the study of the history of the Great Patriotic War of 1941–1945, the partisan movement on the territory of Kalmykia, the heroic work of mine clearance officers, local authorities and the population of the republic.
Flavor Development of Ground Beef from 3 Muscles, 3 USDA Quality Grades, and 2 Wet-Aging Durations
Authors: Hernandez M. Sebastian , French Caroline N. , Legako Jerrad F. , Thompson Leslie D. , Miller Markus F. , Brooks J. Chance
Published: January 2024

The objective of this study was to understand the influence of USDA quality grade, muscle, and aging duration on ground beef flavor development. Prime (PR), Low Choice, and Standard quality grade beef subprimals were collected and aged for either 21 or 42 d. Following aging, subprimals were fabricated into gluteus medius (GM), biceps femoris (BF),and serratus ventralis (SV) then ground and formed into patties. Raw patties were designated for proximate composition, fractionated fatty acids, and thiobarbituric acid reactive substances (TBARS). Cooked patties were designated for consumer sensory analysis, volatile compound analysis, and TBARS. Patties were cooked on a preheated griddle to 72°C. All data were analyzed as split-split plot where quality grade served as the whole plot factor, muscle as the subplot factor, and aging duration as the sub-subplot factor. Significance was determined at P<0.05. A quality grade×muscle interaction was observed for moisture, where regardless of muscle, PR subprimals had the lowest moisture percentage (P<0.05). Raw TBARS was not influenced by any interactions or main effects (P>0.05). Individually, the BF and 42 d aged subprimals had the greatest cooked malondialdehyde concentration (P<0.05). Patties from GM aged for 21 d were rated higher for flavor liking compared to GM aged for 42 d and SV aged for 21 and 42 d (P<0.05). GM patties aged for 21 d were rated higher for overall liking compared to GM patties aged for 42 d (P<0.05). Quality grade did not influence any lipid-derived volatile compounds (P>0.05). The SV produced less Maillard reaction products (P<0.05). Aging for 42 d increased lipid-derived volatiles (P<0.05). Consumer liking of aged product is dependent on muscle. Aging recommendations should be muscle-specific to maximize beef eating experience.
Tzoncuicuilco: persistencia de la memoria
Authors: Aroche Fuentes Nadia
Published: January 2024

El espacio designado como Cuicuilco, en la Ciudad de México, tiene una larga secuencia histórica resultado de la ocupación humana desde el periodo prehispánico hasta la actualidad. En función de ello, en este artículo se propone la permanencia del nombre Cuicuilco bajo el sustrato de la memoria colectiva de su altepetl, respecto al curso de congregación que sufrieron las poblaciones a partir del establecimiento de pueblos de indios y las contribuciones tributarias establecidas, durante el periodo novohispano. Tales hechos históricos se encuentran enunciados en las fuentes que hacen mención del asentamiento de origen prehispánico Tezizimpa y de la fundación del pueblo de indios San Pedro Apostól – Tzoncuicuilco. A través del estudio del topónimo locativo Tzoncuicuilco, se dará a conocer la importancia de la actividad económica que se desarrolló respecto al servicio de “especialización artesanal”, del que fue objeto e hizo pago de tributos en relación con la materia prima disponible en su entorno. Dicha actividad fue delimitada por las instituciones virreinales como aparato de gobierno que estableció los lineamientos de control para la administración de los recursos, población y territorio. La anterior propuesta pretende contribuir al entendimiento de algunos de los procesos culturales que permearon hasta la actualidad y dieron vitalidad al mismo emplazamiento por varios siglos.
perfil y la toponimia del litoral colombo-venezolano en la cartografía lusitano-germánica del primer cuarto del siglo XVI
Authors: Quinche Castaño Carlos Andrés
Published: January 2024

Actualmente expuesto en la Biblioteca del Congreso de los Estados Unidos como el “Acta de nacimiento de América” (a pesar de que dicho topónimo se inscribió exclusivamente sobre lo que ahora se denomina de forma general como América del Sur), el planisferio Universalis Cosmographia, elaborado por Martin Waldseemüller en 1507 y redescubierto en 1901 por Joseph Fischer en Alemania, ha acaparado gran parte de la literatura sobre las representaciones cartográficas tempranas del continente como la muestra más importante de la cartografía lusitano-germánica de principios del siglo xvi, precisamente por ser el primero en incorporar el polémico nombre que hoy lleva nuestro continente. Sin embargo, junto a la designación América existen otros topónimos que no han tenido el mismo protagonismo y que, incluso, las más de las veces pasan desapercibidos, pero que también nos hablan de la historia del entonces llamado Nuevo Mundo y del proceso a través del cual se fue construyendo su mapa. Este artículo busca dar cuenta de las características típicas del contorno y la nomenclatura de la actual costa colombo-venezolana dentro de esta corriente cartográfica, y de cómo este diseño, con sus omisiones, inexactitudes y toponimia alternativa, fue reproducido sin mayores adiciones, correcciones y actualizaciones por más de dos décadas en la Europa Central. Mediante la extracción de los perfiles y la toponimia correspondientes a dicho litoral en los mapas lusitano-germánicos del primer cuarto del siglo xvi y de su análisis en correlación con las fuentes primarias concernientes a los primeros viajes de descubrimiento, la geografía física de la región y la bibliografía secundaria correspondiente, exponemos y argumentamos cómo la cartografía germánica de la llamada “tierra firme” sufrió un estancamiento empírico que se extendió a lo largo de los tres primeros decenios de dicha centuria.
pasos desde el tahli al semanawak: los topónimos nahuas del sotavento veracruzano en el siglo xvi como elementos evocadores del paisaje cultural
Authors: Santiago Gerónimo Carlos
Published: January 2024

En este trabajo se aborda un corpus de seis toponimias en lengua náhuatl del sur de Veracruz y la relación que tienen sus significados con su entorno. A partir del concepto de paisaje que propone la geografía cultural de Paul Claval y de Joan Nogué, se analizan los nominales de algunos pueblos nahuas que pueden ser rastreados en documentos del siglo xvi y xviii. El texto se divide en cinco partes: primero, una introducción donde se explica el concepto de paisaje y su relación con el estudio de la toponimia; segundo, un breve estado de la cuestión sobre las investigaciones relacionadas con la toponimia; tercero, apartado de explicación del origen de las lenguas y las particularidades del espacio geográfico con relación a sus habitantes; cuarto, la presentación de los nominales y el análisis de éstos; y quinto, una conclusión general donde se hará un balance de todo lo expuesto. El objetivo final será mostrar la función de los nominales como evocadores del paisaje de las tierras bajas. Con esto, se contribuye a una mejor comprensión de las dinámicas sociohistóricas que los seres humanos entablan con su entorno y, en particular, cómo el sur de Veracruz posee en su toponimia algunas cualidades relacionadas con el ámbito natural, sociohistórico y religioso.
Metahemoglobinemia Congénita. Reporte de un caso
Authors: Gutiérrez-Riverol Karla , Lozada Rosete Karla Guadalupe , Dosta Herrera Juan José , Cruz Avelar Agles
Published: January 2024

Methemoglobinemia occasionally causes cyanosis particularly in congenital
methemoglobinemia. Avoidance of exposure to oxidizing agents is important for patients with congenital methemoglobinemia because of their deficient enzymatic pathways and decreased oxygen-carrying capacity. Here, we present a pediatric patient with preoperatively undiagnosed congenital methemoglobinemia who underwent catheterization with probably diagnosis of pulmonary hypertension under general anesthesia. The pediatric patient was a 10-year-old who displayed a low pulse oximetry reading of 92% prior to induction of anesthesia. Methemoglobinemia was first suspected intraoperatively because of a mismatch of SpO 2 of finger pulse oximetry and SaO 2 of arterial blood and was later confirmed by multiple wavelength. CO-oximetry. The pathophysiology, etiology, clinical manifestations, anesthetic considerations, and treatment options of methemoglobinemia are discussed.
Key words: methemoglobinemia, cyanosis, anesthesia, pulse oximetry, pediatric patient.
Pembuatan Cookies dengan Penambahan Tepung Hanjeli dan Tepung Daun Kelor
Authors: Shinta Ni Luh Gede Clara , Muliadiasa I Ketut
Published: January 2024

Substitusi pembuatan cookies dengan penambahan tepung hanjeli dan daun kelor. Hanjeli adalah salah satu tanaman serealia yang belum banyak dimanfaatkan di Indonesia tanaman hanjeli ini merupakan tanaman pangan sumber karbohidrat yang setara dengan padi, gandum,dan sorgum. Dan adapun tanaman kelor yang memiliki sumbernutrisi dan kaya akan vitamin, adapun manfaat dari daun kelor yaitu sebagai penangkal radikal bebas. Dalam penelitian ini peneliti ingin memanfaatkan hanjeli dan daun kelor dan ingin mengkreasikannya untuk penambahan di dalam pembuatan cookies. hasil cookies dari penambahan tepung hanjeli dan daun kelor tidak jauh beda dari cookies pada umumnya hanya saja cookies dengan penambahan tepung hanjeli dan daun kelor ini memiliki ciri khas tersendiri. Penelitian ini bertujuan untuk mengetahui pengaruh subsitusi cookies serta untuk mengetahui daya tahan cookies dan analysis cost cookies. adapun metode penelitian yang digunakan yaitu metode eksperimen dengan Teknik pengumpulan data menggunakan kuantitatif dan kualitatif.
 
Making cookies with the addition of hanjeli flour and moringa leaf flour. Hanjeli is one of the cereal crops that has not been widely used in Indonesia. This hanjeli plant is a food plant that is a source of carbohydrates which is equivalent to rice, wheat and sorghum. And as for the moringa plant which has a source of nutrition and is rich in vitamins, as for the benefits of moringa leaves, namely as an antidote to free radicals. In this study, researchers wanted to use hanjeli and moringa leaves and wanted to created them for additions in making cookies. the results of cookies from the addition of hanjeli flour and moringa leaves arenot much different from cookies in general, its just that these cookies with the addition of hanjeli flour and moringa leaves have their own characteristics. This study aims to determine the durability of cookies and cookies cost analysis. As for the research method used is the experimental method with data collection techniques using quantitative and qualitative.
La religión de las cosas
Authors: Bravo Rodríguez Juan
Published: January 2024

Ana, una joven indígena esclavizada en los llanos orientales colombianos, condenada a la tragedia inminente, los hermanos Sánchez, asesinos de abuelos con el dilema entre la vida y la muerte idealizados hacia el descanso eterno, Sandra y su hija pequeña, encasilladas en un ritual de brujería indescifrable, Roger, un extranjero en búsqueda de una tribu indígena latinoamericana perdida, Samuel, un abuelo con una vida confusa e inexplicable, dedicado al trabajo de revivir las esperanzas del pueblo epifiado, y Daniel, supuesto nieto de Samuel, sobreviviente de una realidad que no entiende, se enfrentan a diversas situaciones que se resaltan como trampas, momentos circunstanciales de revelación y de angustia, de lucha y desespero, de dolor y de crueldad, para descubrir el porqué de sus trágicas dolencias. Estas historias giran en torno de la vida real de sus protagonistas, y que comprendieron, luego del golpe certero, que el corazón, entre más profundas tenga las heridas, más cercano está de “Las cosas”.
Estrategias empresariales: un caso de economía solidaria
Authors: Perdomo Paredes Sandra
Published: January 2024

El presente libro, es producto del trabajo de investigación denominado Estrategias empresariales para la Asociación de mujeres rurales de Colombia y el Caquetá ASMUCOCA, el cual posee dos (2) capítulos, el primero de ellos aborda temáticas como: Estrategia empresarial y la economía solidaria, en la cual se da a conocer qué son las estrategias empresariales, las estrategias empresariales en la economía solidaria y la importancia de la planeación en las estrategias empresariales de las organizaciones de la Economía solidaria, así mismo se hace alusión al caso de estudio ASMUCOCA, el cual se desarrolla bajo la metodología de la planeación estratégica. El segundo capítulo, relaciona la propuesta de estrategias a desarrollar en cada área funcional de ASMUCOCA, esta propuesta se realiza basado en los resultados de la Planeación estratégica, la cual escala de manera descendente a la planeación táctica, con el fin de mejorar el nivel de productividad de las organizaciones de economía solidaria.
Las ciencias humanas y sociales en la agenda regional de los organismos multilaterales
Authors: Jiménez García Williams Gilberto
Published: January 2024

El propósito del presente capítulo es demostrar la forma cómo se configura la agen-da regional de organismos multilaterales con respecto a las Ciencias Sociales y las Humanidades. Para este fin, se hizo un rastreo de información en tres organismos multilaterales a los cuales pertenece Colombia, el cual permitió cuantificar y definir las tendencias temáticas en estos organismos. Luego se confrontó con la matriz político-económica de América latina y se encontraron los puntos de encuentro entre las tendencias y la matriz mencionada. Como resultados, se pudo evidenciar el peso temático de las ciencias sociales y las humanidades en estos organismos y la configuración de una agenda temática que guía su acción.
Los materialistas de la antigüedad y su influencia en el Marxismo y en el Feminismo
Authors: Arango Ospina Edgar Dario
Published: January 2024

El modelo de pensamiento occidental ha basado su desarrollo en las ideas platónicas y aristotélicas. Todo esto con base en la influencia que tuvo la aplicación de la religión judeocristiana en el Imperio romano y su correspondiente descendencia. El modelo aristotélico ha permitido que las teorías cristianas tengan un sustento teológico. Pero el modelo idealista de Platón y Aristóteles no era el único en la antigüedad. En el ostracismo quedó un modelo diferente y alternativo que permitió a los griegos entender el universo de una forma diferente, la materialista. Nos referimos a las ideas atomistas de Leucipo, Demócrito y Epicuro. Equivocadamente hemos creído que el epicureísmo desembocó en el estoicismo, pero en realidad tan solo algunas ideas de la ética de Epicuro fueron retomadas por los estoicos. En el olvido quedó lo más importante y nos referimos a las ideas de la física de la naturaleza. Tan solo en la modernidad, el filósofo alemán Carlos Marx, en su tesis de grado Diferencia de la filosofía de la naturaleza en Demócrito y en Epicuro, rescató dicho pensamiento de la antigüedad. En este trabajo pretendemos hacer un análisis de la forma en que estos pensadores de la antigüedad ejercieron influencia con sus ideas y sus modelos cognitivos en el marxismo y en el feminismo modernos. La primera parte de este libro corresponde al estudio desarrollado para la tesis de grado en la UNAD. Este apartado trata más específicamente la forma en que vemos cómo los antiguos atomistas resurgen en las ideas del joven Marx, y también vemos cómo el joven Marx logra rescatar e implementar el materialismo antiguo para interpretar el mundo moderno. Ya en la segunda parte tratamos de plasmar de una forma más precisa, la forma en que, a partir de una nueva visión materialista de las emociones, específicamente el amor y la rabia, podemos dar un vuelco total y entender estas emociones como arma de batalla para el feminismo. De esta forma logramos entramar varios conceptos que en muy pocas ocasiones el pensamiento occidental se ha atrevido a plantear: un feminismo marxista basado en las ideas atomistas de la antigüedad.
Generación de una cultura en ética de la investigación, bioética e integridad científica
Authors: Duque Ortiz Deyanira , Rincón Meléndez Magda Liliana , Martínez Ojeda Betty , Rodríguez González Diana María , Useda Sánchez Edith Yohanna , Flechas Chaparro Nancy Esperanza , Bernal Lizarazú María Consuelo , Castañeda Ayala David Armando , Cáceres Matta Sandra Viviana , García Alarcón Rodrigo
Published: January 2024

El libro “Generación de una Cultura en Ética de la Investigación, Bioética e Integridad Científica”, es producto de procesos de reflexión y discusión colectiva, entre los actores del SNCTeI, vinculados al Ministerio de Ciencia Tecnología (Minciencias) y, la Universidad Nacional Abierta y a Distancia (UNAD); La Universidad Minuto de Dios, Bogotá (UNIMINUTO); La Universidad Libre, Cali; La Universidad de Nariño, Pasto. Universidad del Sinú, Cartagena; Universidad de San Buenaventura, Cartagena e investigadores independientes interesados en temas de Ética de la Investigación, Bioética e integridad Científica. Señala la importancia de la formación, para la generación y apropiación de una cultura en Ética de la Investigación, Bioética e Integridad Científica, como parte de la hoja de ruta propuesta desde la Política de ética de la investigación, Bioética e integridad científica-EIBIC, (Minciencias, 2018). Se aborda los temas: Sesgos Cognitivos, Actitudes y Comportamientos que inciden en los procesos de investigación e innovación en las Áreas de Conocimiento señaladas por la OCDE: Ciencias Ambientales; Ciencias Básicas, Ciencias Sociales, Humanidades, Artes y Educación; Ciencias Biomédicas e Ingeniería. Todo proceso de investigación e innovación debe ser autocrítico fomentando la cultura en EIBIC en todos los niveles educativos.
Protocolo para a extração, identificação e quantificação de ácidos graxos voláteis (AGVs) em silagem usando Cromatografia líquida de alta eficiência em fase reversa acoplada a detetor de arranjo de diodos (RP-HPLC-DAD)
Authors: Castillo Vargas Julián Andrés , Costa de Araújo Tiago , Mezzomo Rafael
Published: January 2024

O perfil de ácidos graxos de cadeia curta (AGCCs) ou ácidos graxos voláteis (AGVs) na silagem, fornece informações significativas sobre o seu padrão fermentativo ruminal, as suas condições de armazenamento e o seu potencial aproveitamento pelo animal. O presente capítulo descreve uma metodologia para extrair, identificar e quantificar AGVs em silagem, utilizando a cromatografia líquida de alta eficiência em fase reversa acoplada ao detector de arranjo de diodos (RP-HPLC-DAD). O método envolve a ex-tração sólido-líquido dos AGVs em amostras de silagem. O extrato aquoso de silagem obtido é misturado com ácido fosfórico 0,85% m/m, onde o extrato final é analisado por RP-HPLC-DAD após microfiltração. Os AGVs são quantificados pelo método de pa-drão externo.
Protocolo para o estudo da biohidrogenação ruminal de ácidos graxos insaturados de suplementos lipídicos misturados com forrageiras usando uma abordagem in vitro
Authors: Castillo Vargas Julián Andrés
Published: January 2024

A biohidrogenação ruminal de ácidos graxos insaturados da dieta tem um efeito im-portante na qualidade composicional final da carne e do leite de ruminantes. Assim, diversas abordagens metodológicas têm sido desenvolvidas para compreender e mo-dular esse processo bioquímico que ocorre no rúmen. Portanto, no presente capítulo, é apresentado um protocolo para realizar um ensaio in vitro para entender a biohidro-genação de ácidos graxos poliinsaturados no rúmen. O protocolo permite avaliar os efeitos de diferentes relações entre os ácidos linoleico e alfa-linolênico em suplemen-tos sobre a produção de intermediários de ácidos graxos derivados da biohidrogena-ção desses ácidos graxos insaturados no rúmen, usando uma abordagem in vitro. Nes-te protocolo, propõem-se os passos experimentais para simular a escala laboratorial, o processo de fermentação ruminal e, assim, a biohidrogenação de ácidos graxos insa-turados, os quais são posteriormente separados, identificados e quantificados usando cromatografia gasosa acoplada a detector de ionização em chama (GC-FID).
Numerical Computation of Non-linear Convection Flow of Micro-polar Fluids over Non-Isothermal Cylinder
Authors: ibrahim wubshet , Zemedu Chaluma
Published: January 2024

The aim of this article is to analyze the impacts of Eckert, surface
temperature and heat flux on two boundary layer flow of non-linear
convection flow of micro-polar fluid past non-isothermal cylinder. The
mathematical modeling for the flow problem has been created with
suitable similarity transformation and dimensionless variable. The main
nonlinear boundary value problems were reduced into mixed high order
non-linear ordinary differential equations. The equations were solved
using the method bvp4c from matlab software for numerous quantities of
main constraints. The impacts of constraints on velocities, surface
temperature and heat flux are examined and displayed through the graphs
and tables. The convergence test has been maintained; for number of
spots greater than apposite mesh number of spots, the precision is not
affected. Moreover, a comparison with previous paper reachable in the
literature has been reported and an excellent agreement is obtained. The
acquiring shows that enhancing in the values of surface temperature and
heat flux constraints (F, H) is to improve thermal diffusion that
improve temperature distributions q(h);h(h).
PEDIATRIC INTRACRANIAL INFLAMMATORY MYOFIBROBLASTIC TUMOR: A RARE CASE WITH DCTN1-ALK FUSION AND RESPONSE TO ALK INHIBITOR
Authors: Garbuzov Anna , Warrier Rajasekharan , falcon corey
Published: January 2024

Inflammatory myofibroblastic tumor (IMT) is a rare cancer that is most
commonly found in children and young adults, and it is usually detected
in the lungs and abdomen. IMT is often associated with an anaplastic
lymphoma kinase (ALK) gene rearrangement. We report the case of a
17-year-old male with ALK positive intracranial IMT managed with
surgical resection and entrectinib, an ALK inhibitor. This case shows
the importance of gene sequencing in diagnosing central nervous system
(CNS) tumors and the promising role of ALK inhibitors in IMT treatment.
Hypersensitivity to alectinib resulting in successful substitution to
entrectinib was also noteworthy.
Super-response to cardiac resynchronization therapy after transcatheter aortic valve implantation: A case report.
Authors: BITRIÁ CARMEN DEJUÁN , CARNEVALLI HUGO DEL CASTILLO , RODIL BELEN BISCOTTI , TORRES JUAN DUARTE , MARSCHALL ALEXANDER , CALVA FREDDY DELGADO , ANTÓN SALVADOR ÁLVAREZ , SANCHEZ DAVID MARTÍ
Published: January 2024

The impact of left bundle branch block (LBBB) after transcatheter aortic
valve implantation (TAVI) on cardiac function remains uncertain. Its
pathophysiology resembles a predominant electrical problem rather than
myocardial damage. We present a case of deep prosthetic implantation,
accompanied by LBBB in whom early treatment with CRT produced a striking
improvement in cardiac function, preventing the development of real
LBBB-induced cardiomyophathy.
GhMYB36, an R2R3 MYB transcriptional factor, confer drought tolerance and Verticillium dahliae resistance by enhancing PR1 gene expression in plants
Authors: Liu Tingli , Chen Tianzi , Kan Jialiang , Yao Yao , Guo Dongshu , Yang Yuwen , Ling Xitie , Wang Jinyan , Zhang Baolong
Published: January 2024

Drought conditions and Verticillium wilt disease are two main factors
limit production by preventing cotton from reaching their genetically
predetermined maximum yields. Here, we isolated GhMYB36, a gene encoding
a R2R3-type MYB protein in Gossypium hirsutum, which is confer drought
tolerance and Verticilium wilt resistance both in Arabidopsis and
cotton. GhMYB36 was highly induced by PEG-simulated drought stress
(PSDS) in cotton. GhMYB36-silenced cotton plants were more sensitive to
drought stress and Verticillium wilt resistance. GhMYB36 overexpression
transgenic Arabidopsis and cotton plants showed better drought tolerance
and Verticillium wilt resistance compared to wild type. The
agro-infiltration-based transient expression of fused GhMYB36-GFP in
tobacco cells indicated that GhMYB36 was located in the cell nucleus. In
addition, the analysis of RNA-seq data together with qRT-PCR validation
indicated that GhMYB36 improve the expression level of PR1 in GhMYB36
transgenic Arabidopsis. Luciferase interaction assays showed GhMYB36 was
likely bind to the promoters of PR1 to activate the expression of PR1
and the interaction was confirmed by Yeast one hybrid. Collectively, our
results suggest that GhMYB36 functions as a R2R3-type MYB protein and is
essential to the improvement of drought tolerance and Verticillium wilt
resistance in Arabidopsis and cotton by enhancing the expression of PR1.
Ten years' experience of pediatric idiopathic interstitial pneumonia registration system in Japan.
Authors: Tamai Naotaka , Koinuma Goro , Okada Kuniyuki
Published: January 2024

Background: Pediatric idiopathic interstitial pneumonia (IIP) is a rare
disease with no established diagnostic or therapeutic guidelines.
Hydroxychloroquine (HCQ) has no indication for this disease and is
contraindicated in patients under 6 years of age. The aim of this study
was to evaluate the diagnostic procedure, and efficacy and safety of IIP
treatment in Japan. Methods: The Japanese Society of Pediatric
Pulmonology (JSPP) implemented a registration system from April 2010 to
March 2020. The enrollment criteria were posted on the JSPP website, and
e-mail requests for enrollment from physicians were accepted.
Questionnaires were sent to investigate symptoms, laboratory findings,
treatment effects, and outcomes. Results: Thirty-four patients were
collected in a 10-year period. The age at onset ranged from 0 to 8
years. Genetic testing was performed in 29 cases, and mutations were
found in 17 cases. Lung biopsies were performed in 16 patients, with
nonspecific interstitial pneumonia being the most common cause.
Twenty-eight patients received HCQ, 27 of whom were under 6 years of age
at the start of treatment. The duration of HCQ treatment ranged from 1
month to 13 years, with no reports of retinopathy. Eighteen patients
showed a good course of treatment with monotherapy with either steroids,
HCQ, or a combination of both. Lung transplantation was reported in
three cases. Six patients had died. Conclusion: This study demonstrated
that half of the IIP patients were diagnosed by genetic testing. HCQ was
used safely, including in patients under 6 years of age, with attention
being paid to hypoglycemia.
SARS-CoV-2 infection associated cell entry proteins ACE2, CD147, PPIA, and PPIB as potential prognostic and infection biomarkers in neuroblastoma
Authors: Bergsneider Brandon , Bailey Elise , Ahmed Yusuf , Gogineni Namrata , Huntley Derek , Montano Ximena
Published: January 2024

Introduction: Although most children experience minor symptoms from
SARS-CoV-2 infection, some develop complications including MIS-C.
Neuroblastoma patients may be at higher-risk of infection. We
hypothesized that ACE2, CD147, PPIA and PPIB are poor-prognosis and
SARS-CoV-2 infection biomarkers in neuroblastoma. Results: In-depth
gene-expression-dataset statistical analysis showed ACE2, CD147, PPIA
and PPIB high-expression significantly associated with poor-prognosis
neuroblastomas with amplified MYCN, unfavourable-tumors and patients
older than 18 months of age. Low-expression was associated with the
NTRK1-PTPN6-TP53 module, a good-prognostic marker. Conclusion: ACE2,
CD147, PPIA and PPIB high expression is associated with poor-prognosis
neuroblastomas. These patients may be at higher-risk of SARS-CoV-2
infection.
NON HODGKIN LYMPHOMA PRESENTING AS A PANCREATIC MASS- A RARE ENTITY, TREATED SUCESSFULY WITH R-CHOP
Authors: kalpathi krishnamani , Krishnamani Mithra , Mohiuddin Mansoor
Published: January 2024

Primary pancreatic lymphoma is rare and mimics adenocarcinoma of the
pancreatic head. A 47 year old lady presented with a pancreatic head
mass , diagnosed as DLBCL and was treated with R-CHOP. This case is
presented due to its rarity, and recognising NHL as a differential for a
pancreatic mass.
The association between serum folate and gestational diabetes mellitus: a large retrospective cohort study in Chinese population
Authors: Liu Xiaohui , Bao Yirong , Chen Liwei , Zhang Donglan , Qu Xiaoxian , Qiao Ping , Li Yuhong , Tang Yuping , cao zhijuan , Ying Hao
Published: January 2024

Objective To demonstrate the association between folate and gestational
diabetes mellitus risk during the whole pregnancy. Design Retrospective
cohort study. Setting A tertiary hospital. Population or Sample Pregnant
women who received antenatal care. Methods A retrospective cohort study
included 42478 women who received antenatal care in Shanghai, China from
April 2013 to March 2017 was conducted. Serum folate and vitamin B12
were assayed before 24 gestational weeks and a diagnosis of gestational
diabetes mellitus was made based on International Association of
Diabetes and Pregnancy Study Groups criteria during 24-28 gestational
weeks. General linear models were used to test the association between
serum folate and plasma glucose and estimate the relative risks for
gestational diabetes mellitus after controlling for different
confounders. Restricted cubic spline was used to test the
dosage-response relationship between serum folate and the risk of
gestational diabetes mellitus. Main Outcome Measures Risks for
gestational diabetes mellitus. Results Positive associations were
observed between serum folate and plasma glucose levels consistently
(fasting, 1-h, 2-h). The adjusted relative risks for gestational
diabetes mellitus across serum folate quartiles were 1.00 (reference),
1.14 (95% CI: 1.04, 1.25), 1.41 (95% CI: 1.28, 1.54), 1.53 (95% CI:
1.40, 1.68), respectively (p for trend <0.001) regardless of
vitamin B12 status and the gestational weeks when folate was measured.
Conclusions The findings of the study are significant for improving the
guidelines for folic acid supplementation during pregnancy from a
gestational diabetes mellitus prevention perspective. Keywords Folate;
Gestational diabetes mellitus; IADPSG; Restricted cubic spline; Cohort.
Persistent Hypoxemia after PAPVC Correction :A Special Case Report
Authors: wang wei , zhang Peide
Published: January 2024

Partial anomalous pulmonary venous connection is a rare adult congenital
heart disease that leads to an anatomical lefttoright shunt. Right
superior pulmonary vein and azygos vein open to the superior vena cava,
with atrial septal defect and severe pulmonary hypertension are also
rare congenital anomalies that result in right-to-left shunt. A
52yearold male presented with dyspnea on exertion and fatigue. He was
further diagnosed in our hospital and was found to have the
aforementioned congenital abnormalities, causing a bidirectional shunt.
On further investigation, he was found to have hypoxemia on oximetry.
The patient was treated via surgical corrections of the congenital
anomalies, but still showed persistent hypoxemia after the operation.
After the related diseases were excluded through various examinations,
we finally thought that hypoxemia was probably caused by pulmonary
hypertension.
Temperature rise improves harvest sustainability in a model system despite reduction in carrying capacity
Authors: Fryxell John , Shaw-McDonald Samantha , Wang Xueqi , Betini Gustavo
Published: January 2024

Stage-structured population models parameterized from benchtop trials of
individual growth, reproduction and survival predicted that temperature
rise should make populations of Daphnia magna more resilient to periodic
harvest perturbation, despite reduced stock abundance. We tested these
predictions under controlled laboratory conditions on 24 populations
maintained under constant levels of food abundance, but subjected to
weekly harvest events over 10 weeks. As predicted, unperturbed Daphnia
populations raised at 15◦C were substantially more abundant by the end
of 10 week trials than those raised at 25◦C, but abundance declined
sharply with harvest intensity and Daphnia populations collapsed
entirely at the highest harvest rate, whereas those populations raised
at 25◦C were little affected by perturbation. Our findings suggest that
projected patterns of climate change should tend to make populations
whose growth rates and rate of maturation increase with temperature
better capable of coping with periodic harvest perturbation, despite
declining levels of abundance.
Interleukin-36α inhibits colorectal cancer metastasis by enhancing the infiltration and activity of CD8+ T lymphocytes
Authors: Wu Yahong , wei xiuyu , yao yongjie , wang xiaoxi , sun jiaxin , qiu lu , qi yuanming , gao yanfeng , Zhai Wenjie , Zhao Wenshan
Published: January 2024

Colorectal cancer is one of the deadliest cancers, and the discovery of
new diagnostic biomarkers and therapeutic targets is vital.
Interleukin-36α (IL-36α) is a proinflammatory factor that can initiate
the inflammatory response and promote the systemic T helper-1 (Th1)
immune response. In this study, we investigated the immunological role
of IL-36α in CRC. We found that IL-36α was downregulated in human CRC
tissues. Patients with high IL-36α levels showed better survival and low
IL-36α expression was significantly associated with greater tumor distal
metastasis and TNM stage. We constructed two cell lines overexpressing
IL-36α (CT26-IL-36α and HT29-IL-36α cells). In vitro assays revealed
that IL-36α overexpression reduced the proliferation, migration, and
invasion of CT26-IL-36α, and HT29-IL-36α cells. Using CT26-vector and
CT26-IL-36α tumor xenograft and lung metastasis models, we found that
IL-36α overexpression elicited a significant antitumor effect and
inhibited lung metastasis in vivo. These inhibitory effects were
associated with an increase in the number of CD3+CD8+ T lymphocytes
within the tumor tissue as well as increased cytokine production in CD8+
T lymphocytes present in the tumor, spleen, and draining lymph nodes.
Furthermore, we revealed that CT26-IL-36α cells enhanced the secretion
of CXCL10 and CXCL11 from chemotactic CD8+ T lymphocytes, as compared
with CT26-vector cells. Taken together, these results suggest that
IL-36α is a promising therapeutic agent for targeting CRC by promoting
the activation, proliferation, and tumor infiltration of T lymphocytes.
The latest research progress in the production of lactic acid by lactic acid bacteria
Authors: Tian Xuejiao , Chen Hao , Liu Hao , Chen Jihong
Published: January 2024

Background: LAB are important probiotics and are considered safe
food-grade microorganisms. With the continuous in-depth study of LAB,
which was discovered that LAB are faces various environmental pressure
phenomena in applications. These stressful environments will obviously
worsen the physiological condition of LAB, which in turn will affect the
production of their fermentation and metabolites. Purpose: In order to
realize the industrialization of cheap biological raw materials and
reduce the cost of raw materials. Based on biomass resources, the
economical fermentation processes have become a research focus. Summary:
This article reviews the application status of cheap raw materials in
LAB, focusing on the development of biomass resources based on LAB
fermentation. discusses the bottlenecks in the production and metabolism
of LAB, and prospects the development of LAB. Conclusion: It provides a
theoretical basis for the construction of process engineering technology
and metabolic regulation. In addition, the use of modern biotechnology
strategies to screen target strains needed to increase LA production was
also discussed, such as adaptive evolution.
Interactions Among Rumen Fermentation Characteristics, the Microbiota, and Host Gene Expression in Response to Ambient Temperature Fluctuations in Tibetan Sheep
Authors: Lv Weibing , liu xiu , sha yuzhu , shi hao , wei hong , luo yuzhu , wang jiqing , li shaobin , hu jiang , guo xinyu , pu xiaoniing
Published: January 2024

As an important ruminant on the Qinghai-Tibet Plateau, Tibetan sheep can
maintain their population reproduction rate in the harsh high-altitude
environment of low temperature and low oxygen, which is related to their
special adaptations to the plateau. Microbes (known as “second
genomes”) play an important role in the host adaptations. However,
there have been no reports on the effects of the interactions among
rumen fermentation, the microbiota, and host gene expression on the
adaptation of Tibetan sheep to high altitude. In this study, rumen
fermentation characteristics, the microbiota, and rumen epithelial gene
expression of Tibetan sheep in various months were analyzed. The results
show that the rumen fermentation characteristics of Tibetan sheep
differed in different months. The total SCFA, acetate, propionate, and
butyrate concentrations were highest in Oct and lowest in Jun. The CL
activity was highest in Feb, while the ACX activity was highest in Apr.
In addition, the diversity and abundance of rumen microbes differed in
different months. Bacteroidetes (53.4%) and Firmicutes (27.4%) were
the dominant phyla. Prevotella_1 and Rikenellaceae_RC9_gut_group
were the dominant genera. The abundance of Prevotella_1 was highest in
Jun (27.8%) and lowest in Dec (17.8%). In addition, the expression of
CLAUDIN4 and ZO1 was significantly higher in Apr than in Aug and Dec,
while the expression of SGLT1 was highest in Aug. Correlation analysis
showed that there were interactions among rumen fermentation
characteristics, the microbiota, and host gene expression, and the host
adjusted the rumen fermentation and microbiota structure according to
changes in ambient temperature, to adapt to the plateau environment.
THE RELATIONSHIP BETWEEN TAS2R38 AND TAS1R2 POLYMORPHISMS AND DENTAL STATUS IN OBESE CHILDREN
Authors: kilic munevver , Gürbüz Taskin , Cayir Atilla , Yuce Cigdem Kahraman , Kurt Yusuf , Bilgic Abdulbaki
Published: January 2024

Aims of the study: We aimed to investigate the effects of TAS2R38
(bitter taste gene) and TAS1R2 (sweet taste gene) gene polymorphisms,
which are the most important members of the Tat gene family, on the
dental status of obese and normal-weight children. Methods used to
conduct the study: The study included 78 healthy children and 100
children diagnosed with obesity (5 - 16 years old). Anthropometric
measurements and the dental status of the children were evaluated. The
DMFT/dmft index of teeth was determined, using standards methods
recommended by world health organization. Blood samples were collected
from all subjects and were analyzed via PCR using specific primers for
the genetic analyses. Five single nucleotide polymorphisms (SNPs)
indicating TAS2R38 gene and TAS1R2 polymorphisms were investigated.
Truncate poisson and truncate negative binomial modeling approach used
with the data. Results of the study: DMFT score was low in obese
children and it was high in children who doesn’t sense bitter taste
(non-taster). While obese non-taster children had increased DMFT scores,
normal weighted non-taster children had decreased DMFT scores.
Conclusions drawn from the study and clinical implications: The alanine,
valine, and isoleucine (AVI), as well as the proline, alanine, and
valine haplotypes (PAV), of the TAS2R38 gene are associated with DMFT
score and obesity. What’s Now: It is known that the sense of taste
affects nutrition. Moreover, nutrition is associated with caries and
obesity. What’s New: The authors studied caries and obesity along with
taste genes in this study. There are little studies in the literature
that study obesity, decay and taste genetics together, and this study
clarifies this issue in three ways. At the same time, an effort was
given to the statistical analysis part Keywords: Oral health, childhood
obesity, tooth decay, TAS2R38 polymorphism, diet, genetic
Adverse Drug Reactions reporting and pharmacovigilance: its importance
Authors: Zondi Sindiswa , Naidoo Panjasaram
Published: January 2024

The use of medicines is unavoidable. The use of in vivo and in vitro
techniques in drug development is not sufficient for medicine approval.
In the development of drugs there are clinical stages that are carried
out to ensure the safety and efficacy of medicines. Medicines in
preproduction elicit different effects and reactions from those elicited
in the post production, as those are influenced by longer treatment
exposure, polypharmacy, bioavailability and metabolism. The post
marketing surveillance stage ensures the detection of adverse drug
reactions (ADRs) which were not detected during clinical stages. The
establishment of pharmacovigilance (PV) systems was prompted by the
thalidomide disaster, the death of Hannah Greener due to use of
chloroform, the Biologics Control Act, the Food and Drug Act,
Durham-Humphrey Amendment and the Kefauver-Harris amendments. For a good
and efficient PV system it is imperative that ADRs are reported,
quantified and documented. Since the inception of PV in South Africa in
1992, the system has progressed from passive regulatory reporting to
active surveillance activities. Studies have shown many barriers to
passive reporting of ADRs in the health care sector such as poor
knowledge by health care providers to completing the reporting form,
reporting is time consuming, and when reporting is done, there is no
acknowledgement of the submitted forms by the PV authorities. ADRs bring
about a financial burden in health budgets, therefore the management of
ADRs and more over of preventable ADRs is essential.
The Association of Dietary Acid-Base Load with Psychological Disorders, Sleep, and Circadian Rhythm among Obese and Overweight Women: A Cross-Sectional Study
Authors: Mirzababaei Atieh , mehranfar sanaz , shiraseb Farideh , Abaj Faezeh , Clark Cain , mirzaei khadijeh
Published: January 2024

Abstract Background: Epidemiologic studies have reported that dietary
acid load is associated with psychological disorders through different
pathways. We aimed to examine the association of dietary acid-base load
with Psychological Disorders, Sleep and circadian rhythm. Methods: This
study was performed on 404 female subjects ≥18 years old. We evaluated
potential renal acid load (PRAL), net endogenous acid production (NEAP)
score by a valid food frequency questionnaire (FFQ) for Iran of with 147
items. To assess psychological disorders, an Iranian validated version
of depression, anxiety, and stress scale (DASS-21) was used. The
Pittsburgh Sleep Quality Index (PSQI) and morning-evening questionnaire
(MEQ) were applied to evaluate sleep quality and circadian rhythm status
respectively. Results: Considering a wide range of confounding
variables, compared with the low adherence, a significant positive
association was observed between dietary acid-base load and severe
depression (OR PRAL =1.10, 95%CI=1.01-1.19, P=0.02) and (OR NEAP =2.46,
95%CI=1.41-14.61, P=0.02). Women in the high dietary acid base load
category had higher anxiety (ORPRAL=1.12,95%CI=1.02-1.23, P=0.01) and
(ORNEAP=1.80,95%CI=1.12-10.72, P=0.01). There was a strong positive
relationship between dietary acid-base load and sleep disturbance
(P<0.05). Additionally, circadian rhythm assessment showed
that those with greater commitment to PRAL had 23% higher risk of being
completely E-type, while odds of being completely M-type, was decreased
by 15% and 12% across higher adherence to PRAL and NEAP. Conclusion:
Women with higher dietary acid-base load score had greater odds for
depression, anxiety, psychological distress, sleep disturbance and
circadian rhythm compared to lower ones.