bluuebunny/crossref_metadata_2025 huggingface dataset:
The Changes in Socio-Cultural Behaviour of the Society in Mining Quarry Area of PT. Newmont Nusa Tenggara in West Sumbawa Regency, Indonesia
Authors: H. Idris Mustamin , Abudllah Ibrahim , Jandra Mifedwil
Published: November 2018

The aims of this research are: 1) to investigate and find out forms of changes in socio-cultural behaviour of the community who live around the mining area; 2) to obtain how the existing social order works within the community of the mining area; and 3) to get the efforts to be done in order to keep balances of socio-cultural development amongst the community of the mining area. The research was carried out in West Sumbawa Regency and sample of the research was Jereweh district as the primary location including some villages, such as, Beru, Belo, Goa, Sekongkang Atas, Sekongkang Bawah while Taliwang and Seteluk districts as a comparative location of the sample. The research was a qualitative research method and data were obtained through observation, questionnaire, documentary, deep-interview and Participatory Rural Appraisal. Result of the research shows that the presence of mining industry of PT. Newmont Nusa Tenggara brought an impact to the community’s behaviour both a positive impact and negative one toward social, cultural, economy, and political aspects.
Learning Strategies To Adjust The Madrasah Ibtidaiyah Curriculum
Authors: Asnafiyah Asnafiyah , Hehsan Aminudin
Published: November 2018

Relevance principle is one of the principles in curriculum development. A curriculum should be relevant to the previous curriculum. Curriculum arrangement in Madrasah Ibtidaiyah Teacher Education program is meant to prepare the student as Madrasah Ibtidaiyah teacher candidate in order that they can do assignments well. Therefore, curriculum in Madrasah Ibtidaiyah Teacher Education program must be relevant to the curriculum used in Madrasah Ibidaiyah. Learning Strategy is one of the subjects in Madrasah Ibtidaiyah Teacher Education program curriculum. Some learning strategies are given to Madrasah Ibtidaiyah Teacher Education program student. The learning strategy on Civics and Pancasila Education were included in Madrasah Ibtidaiyah Teacher Education program curriculum according to learning strategy found in Madrasah Ibtidaiyah thematic curriculum 2013 book. Contextual learning or significant learning in Madrasah Ibtidaiyah Teacher Education program curriculum translated on 2013 Madrasah Ibtidaiyah curriculum to meaningful learning experience by the subtitles Lets Find, Lets Study, Lets Tell, Lets Join, Lets Sing, Lets Practice, Lets Write, Lets Discuss, Do you know, and Learn at home at the student text book. Learn at home contains information in order that parents and students can learn together. Other strategies that taught in Madrasah Ibtidaiyah Teacher Education program curriculum or used in Madrasah Ibtidaiyah curriculum are the Independent Learning strategy, Snowballing, and Critical Incident.
Factors Contributing to Inefficient Management and Maintenance of Waqf Properties: A Literature Review
Authors: Abas Farah Nadia , Raji Fauziah
Published: November 2018

Fundamentally, an effective management of properties has been established as a healthy way of increasing the value and benefits of real estate. The sources of awqaf (waqf) are quite rich. However, the issues of the sustainability of valuable waqf properties have not yet been explored especially with regards to sustaining and enhancing the value through sound principles of property management. Thus, this paper presents a literature review concerning the factors contributing to inefficient management and maintenance of waqf properties globally with a particular focus on Malaysia. From the findings, they have five factors identified that consist of; insufficient fund, lack of best performance by waqf manager, unregistered of waqf land under SIRC, out-dated data and confiscation of ownership rights by heirs from SIRC. Yet, due to the lack of study in the area of the maintenance function of waqf properties, it strongly suggested that there is a need to fill the gap in the body of knowledge of which both; management and maintenance function (operational management) shall take into account in waqf management practice as well. This is very important to achieve sustainability of valuable waqf properties by providing a continuous stream of income through effective and efficient of the waqf management system.
Stochastic simulation of pattern formation in electron beam lithography
Authors: Yasuda Masaaki , Koyama Masanori , Shirai Masamitsu , Kawata Hiroaki , Hirai Yoshihiko
Published: November 2018

A molecular scale simulation of the pattern formation process in electron beam lithography based on the stochastic approach is proposed. The formation of the initial resists structure is achieved by sequentially joining randomly selected monomers. The effects of electron exposure for positive-type resists are introduced by scission of the polymer chain. The effects of electron exposure for negative-type resists are introduced by crosslinkings among the polymer chains. The fundamental properties, such as sensitivity curves, molecular weight dependence, and exposure condition effects on pattern profiles, are well reproduced by the simulation. The simulation results are shown to be appropriate when compared with the properties reported from the experiment.
Three-dimensional printable ultrasound transducer stabilization system
Authors: Derrick Donald , Carignan Christopher , Chen Wei-rong , Shujau Muawiyath , Best Catherine T.
Published: November 2018

When using ultrasound imaging of the tongue for speech recording/research, submental transducer stabilization is required to prevent the ultrasound transducer from translating or rotating in relation to the tongue. An iterative prototype of a lightweight three-dimensional-printable wearable ultrasound transducer stabilization system that allows flexible jaw motion and free head movement is presented. The system is completely non-metallic, eliminating interference with co-recorded signals, thus permitting co-collection and co-registration with articulometry systems. A motion study of the final version demonstrates that transducer rotation is limited to 1.25° and translation to 2.5 mm—well within accepted tolerances.
Velocity dispersion and backscatter in marrow-filled and water-filled trabecular bone samples in vitro
Authors: Lee Kang Il
Published: November 2018

The phase velocity and the backscatter coefficient were measured in 28 bovine femoral trabecular bone samples filled with marrow and water in vitro from 0.2 to 0.6 MHz. The phase velocities decreased approximately linearly with increasing frequency and the average dispersion rate of −34 ms−1 MHz−1 in the marrow-filled samples was higher than that of −42 ms−1 MHz−1 in the water-filled samples. The backscatter coefficients exhibited nonlinear, monotonically increasing dependences on the frequency and the average value of the exponent n = 2.92 (frequency dependence) in the marrow-filled samples was higher than the value of n = 2.79 in the water-filled samples.
Deciphering and engineering chromodomain-methyllysine peptide recognition
Authors: Hard Ryan , Li Nan , He Wei , Ross Brian , Mo Gary C. H. , Peng Qin , Stein Richard S. L. , Komives Elizabeth , Wang Yingxiao , Zhang Jin , Wang Wei
Published: November 2018

Chromodomain-peptide recognition specificity is decided by physiochemical properties defined by posttranslational modifications.
TET2 coactivates gene expression through demethylation of enhancers
Authors: Wang Lu , Ozark Patrick A. , Smith Edwin R. , Zhao Zibo , Marshall Stacy A. , Rendleman Emily J. , Piunti Andrea , Ryan Caila , Whelan Anna L. , Helmin Kathryn A. , Morgan Marc Alard , Zou Lihua , Singer Benjamin D. , Shilatifard Ali
Published: November 2018

An epigenetic axis directs a transcriptional program via enhancer activation by MLL3 COMPASS and TET2-dependent DNA demethylation.
Keeping pace with the mouse heart
Authors: Lavine Kory
Published: November 2018

A miniaturized and programmable pacemaker for mice demonstrates the feasibility of long-term cardiac pacing to study cardiac arrhythmias and heart failure.
Initial excited-state structural dynamics of 2′-deoxyadenosine
Authors: Sasidharanpillai Swaroop , Friedman Adam A. , Loppnow Glen R.
Published: November 2018

Purine nucleobases (adenosine and guanosine) are prone to spontaneous breaking of the nucleosidic bond to form abasic sites in both DNA and RNA. However, the purines also undergo photochemical reactions, including oxidation and cycloaddition, to form damage sites, albeit at lower photochemical quantum yields than the pyrimidines. In this study, we use ultraviolet resonance Raman spectroscopy to measure the initial excited-state structural dynamics in the nucleoside, 2′-deoxyadenosine. The resonance Raman-derived initial excited-state structural dynamics throughout the 260 nm La excited electronic state of adenine are found to be smaller in the nucleoside than in the previously reported 9-methyladenine nucleobase derivative, consistent with what is found for the pyrimidines thymine and uracil. Interestingly, resonance-enhanced vibrational modes in this electronic state also contain internal coordinates localized on the sugar, which may represent a different energy dissipation mechanism than in the pyrimidine nucleosides. The results will be discussed in terms of the initial excited-state photophysics and photochemistry of DNA and RNA.
Testing of Permian – Lower Triassic stratigraphic data in a half-graben/tilt-block system: evidence for the initial rifting phase in Antalya Nappes
Authors: Şahin Nazif , Altiner Demir
Published: November 2018

Testing of Middle Permian – Lower Triassic stratigraphic data from the Antalya Nappes in a half-graben/tilt-block system has revealed the presence of episodic rifting events separated by periods of tectonic quiescence. Following a period of uplift during the Permian (Late Artinskian to Roadian), the basement rocks have been activated by displacement faults and several depocenters in half-graben-like asymmetrical basins began to be filled with Roadian to Wordian continental clastic deposits intercalated with coal and marine rocks. The Early Capitanian time was a period of tectonic quiescence. The second event occurred in Middle to Late Capitanian times and produced basaltic volcanic rocks intercalated in the shallow marine fossiliferous carbonate successions. Following the Lopingian (Wuchiapingian and Changhsingian) and Permian–Triassic boundary interval representing a long tectonic quiescence, the last rifting episode started with an abrupt facies change in the late Griesbachian. Variegated shales, limestones, volcanics, talus breccia, and debris flow deposits were laid down in a half-graben/tilt-block system. As normal faulting has become active, the deposition continued on the subsiding hanging wall side. The stratigraphic gap increased in magnitude as the erosional truncation has incised deeply the footwall side. This initial rifting phase in the Antalya Nappes is prior to the onset of a stronger and more continuous rifting event that occurred in the Anisian–Carnian interval including a variety of deepwater clastic and carbonate deposits, radiolarites containing sometimes blocks and clasts derived from the basin margins, and volcanic rocks carrying intraoceanic setting character.
Impacts of invasive plant species on soil biodiversity: a case study of dog-strangling vine (Vincetoxicum rossicum) in a Canadian National Park
Authors: Bugiel Laura N. , Livingstone Stuart W. , Isaac Marney E. , Fulthorpe Roberta R. , Martin Adam R.
Published: November 2018

Soil microbial diversity is expected to be altered by the establishment of invasive plant species, such as dog-strangling vine (DSV) [Vincetoxicum rossicum (Apocynaceae)]. However, in urban ecosystems where DSV invasion is high, there is little research evaluating the impacts of DSV and other anthropogenic disturbances on microbial diversity. Our study was based in Rouge National Urban Park, Canada, where we used terminal restriction fragment length polymorphism data to evaluate (i) if DSV has a detectable impact on soil bacterial community composition and (ii) if these impacts occur independently of other anthropogenic change or soil characteristics. Variation in soil bacterial communities was greatly reduced in DSV-invaded sites vs. less-invaded sites. The degree of DSV invasion independently explained 23.8% of variation in bacterial community composition: a value similar to the explanatory power of proximity to roadways (which explained 22.6% of the variation in community composition), and considerably greater than soil parameters (pH, moisture, carbon, and nitrogen concentrations) which explained only between 6.0% and 10.0% of variation in bacterial community composition. Our findings indicate that DSV influences soil bacterial community composition independent of other anthropogenic disturbances and soil parameters, with potential impacts on multiple facets of plant–soil interactions and plant invasion dynamics.
Efficient Cluster-Based Heuristics for the Team Orienteering Problem with Time Windows
Authors: Gavalas Damianos , Konstantopoulos Charalampos , Mastakas Konstantinos , Pantziou Grammati
Published: November 2018

In the Team Orienteering Problem with Time Windows (TOPTW), a variant of the Vehicle Routing Problem with Profits, a set of locations is given, each associated with a profit, a visiting time and a time window. The aim is to maximize the overall profit collected by a number of routes, while the duration of each route must not exceed a given time budget. TOPTW is NP-hard and is typically used to model the Tourist Trip Design Problem. The latter deals with deriving near optimal multiple-day tours for tourists visiting a destination with several points of interest (POIs). The most efficient known heuristic approach to TOPTW which yields the best solution quality versus execution time, is based on Iterated Local Search (ILS). However, the ILS algorithm treats each node separately, hence it tends to overlook highly profitable areas of nodes situated far from the current solution, considering them too time-expensive to visit. We propose two cluster-based extensions to ILS addressing the aforementioned weakness by grouping nodes on separate clusters (based on geographical criteria), thereby making visits to such nodes more attractive. Our approaches improve ILS with respect to solutions quality and execution time as evidenced by experimental tests exercised on both existing and new TTDP-oriented benchmark instances.
Analysis similarity index of link prediction based on multivariate statistics
Authors: Tang Minghu , Wang Wenjun
Published: November 2018

Link prediction attracts the attention of a large number of researchers due to the extensive application in social and economic fields. Many algorithms have been proposed in recent years. They show good performance because of having own particularly selected networks. However, on the other networks, they do not necessarily have good universality. Moreover, there are no other methods to evaluate the performance of new algorithm except AUC and precision. Therefore, we cannot help questioning this phenomenon. Can it really reflect the performance of an algorithm? Which attributes of a network have great influence on the prediction effect? In this paper, we analyze 21 real networks by multivariate statistical analysis. On the one hand, we find that the heterogeneity of network plays a significant role in the result of link prediction. On the other hand, the selection of network is very essential when verifying the performance of new algorithm. In addition, a nonlinear regression model is produced by analyzing the relationship between network properties and similarity methods. Furthermore, 16 similarity methods are analyzed by means of the AUC. The results show that it is of great significance for the performance of a new algorithm to design the evaluation mechanism of classification.
The dependence of elastic properties of Cr2AC(A = Al, Ge) compounds on pressure by First-principle calculation
Authors: Shao Ya Ping , Ling Weidong , Duan JiZheng , Yang Yang , Jiang Xin , Duan Wen Shan
Published: November 2018

MAX phases captured attention ever since they were synthesized. They are suited for different applications, especially in high-temperature and extreme environments. So knowledge of mechanical properties is essential for our applications of MAX phases in different situations. Cr2AC (A = Al, Ge) compounds belong to M2AX phases. But, few of their physical properties have been studied. This work demonstrated the compression behavior of Cr2AC (A = Al, Ge) by first-principles method. The elastic constants were calculated in the range of 0–50 GPa, it is shown that they satisfy the requirement of mechanical stability. The values of bulk moduli, shear moduli, Young’s moduli, Possion’s ratio and Lame’s constant were calculated. We also studied brittleness/ductility of Cr2AC(A = Al, Ge). For the more, we studied the dependence of a/a0, c/c0 and bulk moduli on the pressure below 50 GPa. In the end, we calculated the Mulliken bond overlap and theoretical hardness. We also discussed the bonding and antibonding.
Enhanced Parallel Application Scheduling Algorithm with Energy Consumption Constraint in Heterogeneous Distributed Systems
Authors: Li Jinghong , Xie Guoqi , Li Keqin , Tang Zhuo
Published: November 2018

Energy consumption has always been one of the main design problems in heterogeneous distributed systems, whether for large cluster computer systems or small handheld terminal devices. And as energy consumption explodes for complex performance, many efforts and work are focused on minimizing the schedule length of parallel applications that meet the energy consumption constraints currently. In prior studies, a pre-allocation method based on dynamic voltage and frequency scaling (DVFS) technology allocates unassigned tasks with minimal energy consumption. However, this approach does not necessarily result in minimal scheduling length. In this paper, we propose an enhanced scheduling algorithm, which allocates the same energy consumption for each task by selecting a relatively intermediate value among the unequal allocations. Based on the two real-world applications (Fast Fourier transform and Gaussian elimination) and the randomly generated parallel application, experiments show that the proposed algorithm not only achieves better scheduling length while meeting the energy consumption constraints, but also has better performance than the existing parallel algorithms.
Revisiting the Learned Clauses Database Reduction Strategies
Authors: Jabbour Saïd , Lonlac Jerry , Saïs Lakhdar , Salhi Yakoub
Published: November 2018

In this paper, we revisit an important issue of CDCL-based SAT solvers, namely the learned clauses database management policies. Our motivation takes its source from a simple observation on the remarkable performances of both random and size-bounded reduction strategies. We first derive a simple reduction strategy, called Size-Bounded Randomized strategy (in short SBR), that combines maintaining short clauses (of size bounded by k), while deleting randomly clauses of size greater than k. The resulting strategy outperform the state-of-the-art on SAT instances taken from the SAT competitions 2013 and 2018, and remains competitive on a broad range of SAT instances of the SAT Competition 2014. Reinforced by the interest of keeping short clauses, we propose several new dynamic variants, and we discuss their performance. We also propose different ways for adjusting dynamically the size-bounded parameter of the strategy.
CORROSION PROTECTION OF AMORPHOUS CARBON COATING FOR THE BIPOLAR PLATES OF PEMFCs
Authors: CHEN GANG , TAO TAO , GAO PING-PING , XIE ZHI-YONG , WU XIAO-BO
Published: November 2018

A carbon precursor film was formed on a titanium plate by a hydrothermal method using glucose, and an amorphous film was obtained by carbonization at 400∘C under an Ar atmosphere. The morphology and composition of the surface was analyzed by X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS), and the interface contact resistance (ICR) under different pressures by simulating the working mode of the fuel cell. The corrosion resistance of amorphous carbon coatings was tested by simulating the proton exchange membrane fuel cells (PEMC). The amorphous coating showed excellent interfacial conductivity and great corrosion resistance, with high potential application in bipolar plates of PEMFCs
A Generalization of Block Structures in Undirected Interconnection Networks
Authors: ANJALI N. , MATHEW SUNIL
Published: November 2018

This paper extends characterizations of partial blocks proved in a subclass of weighted graphs, to all weighted graphs on at least three vertices. A property of blocks which is also shared by all θ-weighted partial blocks is identified and a related application on ring networks is also suggested.
On 3-Regular Subgraphs in Cartesian Product of Paths
Authors: MIAO LU , YANG WEIHUA
Published: November 2018

The n-dimensional hypercube Qn is bipancyclic and contains a 3-regular, 3-connected subgraph on l vertices for every even l from 8 to 2n except 10. In this paper, we strengthen the previous works to Cartesian product of paths. The bipancyclicity and the existence of 3-regular subgraphs of Cartesian product of paths are studied in this paper.
Matching Preclusion Number of Radix Triangular Mesh with Odd Vertices
Authors: WANG CHUNXIA , LI YALAN , ZHANG SHUMIN , YE CHENGFU , WANG XIA
Published: November 2018

The matching preclusion number of graph G is the minimum number of edges whose deletion leaves the resulting graph without a perfect matching or almost-perfect matching. The strong matching preclusion number of a graph G is the minimum number of vertices and edges whose deletion leaves the resulting graph without a perfect matching or an almost-perfect matching. The conditional matching preclusion number of G is the minimum number of edges whose deletion leaves the resulting graph with no isolated vertices and without a perfect matching or almost-perfect matching. In this paper, we study the matching preclusion number of radix triangular mesh with an odd number of vertices, and strong matching preclusion number and conditional matching preclusion number of radix triangular mesh. Also, we obtained the radix triangular mesh with an even number of vertices is super strongly matched and conditionally super matched.
Embedding Strategies of Mesh Network into the Exchanged Crossed Cube
Authors: WANG XINYANG , QI DEYU , ZHOU NAQIN
Published: November 2018

The topology of interconnection networks plays an important role in the performance of parallel and distributed computing systems, and the embeddings of interconnection networks can help adapt their topology features into new interconnection network structures. Being a basic and popular structure, the mesh network has wide application range as the result of some of its topology features. Meanwhile, as an important variant of hypercube, the Exchanged Crossed Cube(ECQ) combines advantages of crossed cube and exchanged hypercube, i.e. the promotion of network performance and the reduce of communication cost. To enlarge the application range of the ECQ, this paper discusses the embedding strategies of Mesh network into ECQ and proposes 4 methods to embed meshes into ECQ. We distinguish these methods by comparing their dilation, expansion, loading and congestion. The comparison result shows that compromise among four of the above parameters has to be made to achieve the improvement of some parameters.
THE EFFECTS OF SQUARE DANCING ON BONE MINERAL DENSITY AND BONE TURNOVER MARKERS IN PATIENTS WITH POSTMENOPAUSAL OSTEOPOROSIS
Authors: QIN JINZE , RONG XIAOXU , ZHU GUOXING , JIANG YU
Published: November 2018

Objective: To study the effects of square dance on bone mineral density (BMD) and bone turnover markers in patients with postmenopausal osteoporosis.

Methods: Fifty postmenopausal women (aging 45–60) with osteoporosis were randomly assigned to a research group and a control group. The patients in the research group received 600[Formula: see text]mg of calcium combined with square dance (5 times a week, 30 to 60 minutes each time) for 6 months while those in the control group only received 600[Formula: see text]mg of calcium. BMD, changes in bone turnover markers and bone pain were assessed before and after the treatment.

Results: (1) After the 6-month treatment, BMD of L[Formula: see text] and the femoral neck significantly increased in the research group ([Formula: see text]). No significant change was observed in BMD of the Ward’s region. BMD in the control group did not change significantly ([Formula: see text]). (2) No significant difference was found in serum levels of calcium, phosphorus and alkaline phosphatase between the two groups both before and after the treatment ([Formula: see text]). Serum levels of P1NP had a significant increase, while [Formula: see text]-CTX’s level did not change significantly. (3) The bone pain in both groups has been effectively relieved. The pain in the research group was relieved significantly compared to the control group.

Conclusions: By improving the BMD and relieving the pain, square dancing can exert positive effects on women with postmenopausal osteoporosis. Square dancing may become a feasible strategy for osteoporosis prevention and treatment.
Pointwise estimates for Stokes systems with BMO coefficients in Reifenberg domains
Authors: Ma Lingwei , Zhang Zhenqiu , Xiong Qi
Published: November 2018

Pointwise estimates of weak solution pairs to a stationary Stokes system with small [Formula: see text] semi-norm coefficients are established in Reifenberg flat domains by using the restricted sharp maximal function. These pointwise estimates provide a unified treatment of the Calderón–Zygmund estimates for the solution pair to Stokes systems in [Formula: see text] and [Formula: see text] spaces.
Regularized Nyström subsampling in regression and ranking problems under general smoothness assumptions
Authors: Myleiko G. L. , Pereverzyev S. , Solodky S. G.
Published: November 2018

In the supervised learning, the Nyström type subsampling is considered as a tool for reducing the computational complexity of regularized kernel methods in the big data setting. Up to now, the theoretical analysis of this approach has been done almost exclusively in the context of the regression learning and in the case where the smoothness of the target functions is restricted to the Hölder type source conditions. Such conditions do not cover the case of target functions with high and low smoothness, which are also of practical interest. Moreover, in the case of the Hölder source conditions, there is no need to consider a regularization with high enough qualification because order-optimal learning rates are achieved by the simple Tikhonov regularization known also as the kernel ridge regression. At the same time, this learning method does not improve its performance for any smoothness higher than Hölder ones. Therefore, in this paper, our goal is to extend previous analysis of the Nyström type subsampling to the case of the general source conditions, and to the regularization schemes with high enough qualification. We also show that under rather natural assumption, our results can be easily reformulated in the ranking learning setting.
The Influence of Nickel Oxide Nanoparticle Dispersion on the Thermo Stability of Lubricant Oil
Authors: Ramachandran K. , Navaneethakrishnan P. , Sivaraja M.
Published: November 2018

The homogeneous and substantial dispersion of nanoparticles into base fluids is vital since the final properties of any nanolubricant are estimated by their quality of stability. This paper addresses the effect of NiO nanoparticles dispersion into SN500 lubricant oil and its nonisothermal thermo stability. The dispersion of NiO nanoparticles is achieved by ultrasonication method. The thermo stability is estimated by Thermo Gravimetric Analysis (TGA), Differential Thermal Analysis (DTA) and Differential Scanning Calorimetry (DSC). The result shows that the thermo stability of base fluid enhances up to 0.3[Formula: see text]wt.% particle concentration then it decreases due to agglomeration of dispersed nanoparticles. The findings recommend that 0.1[Formula: see text]wt.% and 0.3[Formula: see text]wt.% of NiO-nanolubricant can be used for the temperature-dependent applications up to 200∘C.
Knowledge Acquisition for Importing Existing Traces to a Trace Base Management System
Authors: Besnaci Mohamed , Bensebaa Tahar , Guin Nathalie , Champin Pierre-Antoine
Published: November 2018

Trace Base Management System (TBMS) offers processing and querying functionalities for traces that may be of interest to users of tracked systems. Our goal is to ensure the importing of various external traces into kernel for Trace-Based System (kTBS), which is a TBMS developed in the LIRIS laboratory. To overcome the problem of traces heterogeneity, we propose to define a generic collector. To this end, a user with enough knowledge of the tracked system is prompted to define its kTBS trace model and correspondences between the elements of this model and the elements of the trace to import. The system generalises the mappings previously elicited by the user through interaction to create mapping rules. After this phase, the collector will generate modelled traces from the existing ones and the already defined mapping rules.
A geometric relativistic dynamics under any conservative force
Authors: Friedman Yaakov , Scarr Tzvi , Steiner Joseph
Published: November 2018

Riemann’s principle “force equals geometry” provided the basis for Einstein’s General Relativity — the geometric theory of gravitation. In this paper, we follow this principle to derive the dynamics for any static, conservative force. The geometry of spacetime of a moving object is described by a metric obtained from the potential of the force field acting on it. We introduce a generalization of Newton’s First Law — the Generalized Principle of Inertia stating that: An inanimate object moves inertially, that is, with constant velocity, in its own spacetime whose geometry is determined by the forces affecting it. Classical Newtonian dynamics is treated within this framework, using a properly defined Newtonian metric with respect to an inertial lab frame. We reveal a physical deficiency of this metric (responsible for the inability of Newtonian dynamics to account for relativistic behavior), and remove it. The dynamics defined by the corrected Newtonian metric leads to a new Relativistic Newtonian Dynamics for both massive objects and massless particles moving in any static, conservative force field, not necessarily gravitational. This dynamics reduces in the weak field, low velocity limit to classical Newtonian dynamics and also exactly reproduces the classical tests of General Relativity, as well as the post-Keplerian precession of binaries.
Electrodeposition of catalytically active polyporphyrin films of metal complexes of amino-substituted tetraphenylporphyrins
Authors: Tesakova Mariya V. , Lutovac Mitar , Parfenyuk Vladimir I.
Published: November 2018

The process of electrodeposition of polyporphyrin films based on amino-substituted tetraphenylporphyrins and their metal complexes (CuT([Formula: see text]-NH[Formula: see text]Ph)P, FeClT([Formula: see text]-NH[Formula: see text]Ph)P, MnClT([Formula: see text]-NH[Formula: see text]Ph)P) has been studied by the quartz crystal microbalance method. The surfaces of the films have been characterized by the scanning electron microscopy method and the number of electrons taking part in porphyrin electropolymerization has been determined. It has been established that the most intensive film growth is observed for the metal-free porphyrin ligand. The obtained polyporphyrin films have been analyzed for the catalytic ability in oxygen electroreduction reactions.
The effect of elongation of a peptide substituent with ArgSer motif on the antimicrobial properties of hemin derivatives
Authors: Blagodarov Sergey V. , Zheltukhina Galina A. , Yeremin Sergey V. , Babicheva Ekaterina S. , Mirchink Elena P. , Nebolsin Vladimir E.
Published: November 2018

The natural metalloporphyrin hemin possesses a number of properties that determine its attractiveness as a basis for creating potential medicines. The development of research in this area is restrained by hemin’s pronounced toxicity, mainly in relation to normal red blood cells, and also by its water insolubility. We previously synthesized amino acid and peptide hemin derivatives with sufficient water solubility and in some cases high antimicrobial (antibacterial and antifungal) potency [1, 2]. In order to establish the relationship between structure and function, this paper studies the peptide substituent in hemin derivatives (HD) elongated by multiplying the -ArgSer- motif and its effect on the biological and physicochemical properties of their aqueous solutions. A nonlinear nonmonotonic dependence of their physicochemical properties and biological potency on the HD concentration and the length of peptide substituent was revealed based on calculations of hydrophilic properties of substituents in HD and a study by electron and laser correlation spectroscopy of their properties in aqueous solutions.
Characterization of effective permeability in heterolithic, distal lower-shoreface sandstone reservoirs: Rannoch Formation, Brent Group, UK North Sea
Authors: Onyenanu God'spower I. , Hampson Gary J. , Fitch Peter J. R. , Jackson Matthew D.
Published: November 2018

The reservoir properties of distal lower-shoreface and distal wave-dominated delta-front deposits, which consist of sandstone beds with locally scoured bases and mudstone interbeds, are poorly understood. The lower Rannoch Formation (Middle Jurassic Brent Group) forms an interval of such heterolithic sandstones in many North Sea reservoirs, and is used to illustrate a workflow for rapid estimation of reservoir properties and their sensitivity to key parameters. Mudstone-interbed thickness distributions in cored reservoir successions are compared to the thickness distribution of sandstone scour-fills in an outcrop analogue(s) in order to identify mudstones with the potential to form laterally extensive barriers to vertical flow. Effective
k
v
/
k
h
at the scale of several typical reservoir-model grid cells (200 × 100 × 20 m) is estimated in intervals bounded by these mudstone barriers via a simple analytical technique that is calibrated to previously documented reservoir-modelling experiments, using values of sandstone proportion measured in cored reservoir successions. Using data from the G2 parasequence (Grassy Member, Blackhawk Formation, east-central Utah, USA) outcrop analogue, mudstones bounding 3–8 m-thick, upwards-coarsening successions in the lower Rannoch Formation may define separate stratigraphic compartments in which grid-cell-scale effective
k
v
/
k
h
is estimated to be 0.0001–0.001 using a streamline-based analytical method.
The Global Landscape of Tuberculosis Therapeutics
Authors: Tornheim Jeffrey A. , Dooley Kelly E.
Published: November 2018

Tuberculosis (TB) is one of the oldest infections afflicting humans yet remains the number one infectious disease killer worldwide. Despite decades of experience treating this disease, TB regimens require months of multidrug therapy, even for latent infections. There have been important recent advances in treatment options across the spectrum of TB, from latent infection to extensively drug-resistant (XDR) TB disease. In addition, new, potent drugs are emerging out of the development pipeline and are being tested in novel regimens in multiple currently enrolling trials. Shorter, safer regimens for many forms of TB are now available or are in our near-term vision. We review recent advances in TB therapeutics and provide an overview of the upcoming clinical trials landscape that will help define the future of worldwide TB treatment.
High-Deductible Health Plans and Prevention
Authors: Mazurenko Olena , Buntin Melinda J.B. , Menachemi Nir
Published: November 2018

High-deductible health plans (HDHPs) are becoming more popular owing to their potential to curb rising health care costs. Relative to traditional health insurance plans, HDHPs involve higher out-of-pocket costs for consumers, which have been associated with lower utilization of health services. We focus specifically on the impact that HDHPs have on the use of preventive services. We critique the current evidence by discussing the benefits and drawbacks of the research designs used to examine this relationship. We also summarize the findings from the most methodologically sophisticated studies. We conclude that the balance of the evidence shows that HDHPs are reducing the use of some preventive service, especially screenings. However, it is not clear if HDHPs affect all preventive services. Additional research is needed to determine why variability in conclusions exists among studies. We describe an agenda for future research that can further inform public health decision makers on the impact of HDHPs on prevention.
Kinematic analysis of bimanual movements during food handling by head-fixed rats
Authors: Igarashi Masakazu , Wickens Jeff
Published: November 2018

Bimanual coordination, in which both hands work together to achieve a goal, is crucial for the basic needs of life, such as gathering and feeding. Such coordinated motor skill is highly developed in primates, where it has been most extensively studied. Rodents also exhibit remarkable dexterity and coordination of forelimbs during food handling and consumption. However, rodents have been less commonly used in the study of bimanual coordination because of limited quantitative measuring techniques. In this article we describe a high-resolution tracking system that enables kinematic analysis of rat forelimb movement. The system is used to quantify forelimb movements bilaterally in head-fixed rats during food handling and consumption. Forelimb movements occurring naturally during feeding were encoded as continuous three-dimensional trajectories. The trajectories were then automatically segmented and analyzed, using a novel algorithm, according to the laterality of movement speed or the asymmetry of movement direction across the forelimbs. Bilateral forelimb movements were frequently observed during spontaneous food handling. Both symmetry and asymmetry in movement direction were frequently observed, with symmetric bilateral movements quantitatively more common. The proposed method overcomes a limitation in the precise quantification of bimanual coordination in rodents. This enables the use of powerful rodent-based research tools such as optogenetics and chemogenetics in the further investigation of neural mechanisms of bimanual coordination.

NEW & NOTEWORTHY We describe a new method for quantifying and classifying three-dimensional, bilateral forelimb trajectories in head-fixed rats. The method overcomes limits on quantifying bimanual coordination in rats. When applied to kinematic analysis of food handling behavior, continuous forelimb trajectories were automatically segmented and classified. Bilateral forelimb movements were observed more frequently than unilateral movements during spontaneous food handling. Both symmetry and asymmetry in movement direction were frequently observed. However, symmetric bilateral forelimb movements were more common.
C-Reactive Protein Levels at the Midpregnancy Can Predict Gestational Complications
Authors: Vecchié Alessandra , Bonaventura Aldo , Carbone Federico , Maggi Davide , Ferraiolo Antonella , Carloni Beatrice , Andraghetti Gabriella , Affinito Bonabello Laura , Liberale Luca , Dallegri Franco , Montecucco Fabrizio , Cordera Renzo
Published: November 2018

Although essential for a successful pregnancy, a growing body of evidence suggests that maternal inflammation, when dysregulated, may represent a risk factor for both maternal and neonatal outcomes. Here, we assessed the accuracy of maternal C-reactive protein (CRP) concentrations at the middle phase of pregnancy in the identification of maternal adverse outcomes (MAO) until delivery. A correlation between CRP and a complicated pregnancy including both maternal and neonatal adverse outcomes has been investigated, too. In this retrospective study, conducted at the Diabetology Unit of IRCCS Ospedale Policlinico San Martino, Genoa (Italy), 380 outpatient pregnant women have been enrolled at the prenatal visit before performing a 75 g oral glucose tolerance test at 24th-26th gestational week for gestational diabetes mellitus (GDM) screening. Demographic, medical, and reproductive history has been obtained by verbal interview. Data about pregnancy and delivery have been retrieved from medical records. The median value of maternal baseline serum CRP was 3.25 μg/mL. Women experiencing MAO were older, more frequently suffering from hypertension, and showed higher CRP concentrations, with a cutoff value >1.86 μg/mL found by a ROC curve analysis to be accurately predictive for MAO. By a logistic regression analysis, serum CRP levels >1.86 μg/mL have been found to predict MAO also considering maternal age, hypertension, and GDM. Maternal CRP levels have been positively associated with overall pregnancy adverse outcomes (maternal and neonatal), too. In conclusion, in pregnant women serum levels of CRP can early recognize subjects at higher risk for maternal and neonatal complications needing a more stringent follow-up.
Observation of Gaussian Pseudorapidity Distributions for Produced Particles in Proton-Nucleus Collisions at Tevatron Energies
Authors: Ulugbek Abdurakhmanov , Kadyr Gulamov , Vladimir Lugovoi , Vadim Navotny
Published: November 2018

The statistical event-by-event analysis of inelastic interactions of protons in emulsion at 800 GeV reveals the existence of group of events with Gaussian pseudorapidity distributions for produced particles, as suggested by hydrodynamic-tube model. Events belong to very central collisions of protons with heavy emulsion nuclei with probability of realization of less than 1% and with multiplicity of shower particles exceeding (2-3 times) the average multiplicity in proton-nucleus collisions in emulsion. Bjorken’s energy density for these events reaches 2.0 GeV per fm3. The data are interpreted as a result of the QCD phase transition in proton-tube collisions at Tevatron energies.
The Analytic Study on the Heavy Steel Plate Snake Rolling with the Same Roll Diameters
Authors: Jiang Lian-yun , Meng Qing-cheng , Zhao Chun-jiang , Wang Shou-xin , Liu Yan-wei
Published: November 2018

The deformation in the inner region along the thickness of the heavy steel plate can be improved by snake rolling method. Then the microstructure and property will be refined and the crack in the inner region may be avoided. Therefore, the in-depth research on snake rolling method mechanics parameter modeling should be conducted to guide production. A snake rolling process with the same roll diameters and different angular velocity was conducted in this paper. The rolling deformation zone will be divided into back slip zone, front slip zone, cross shear zone, and reverse deflection zone according to the direction of the friction during the snake rolling process. The four zones may not exist at the same time. The boundary conditions of existence of the back slip zone, front slip zone, and cross shear zone were established according to the relationship between threading angle and neutral angle. The calculating models which were used to calculate the snake rolling mechanical parameters including the rolling force and rolling torque were set up. The calculated models of unit compressive pressure in the four zones were set up by the slab method, and on this basis the accurate calculating models of the rolling force and rolling torque were set up according to the composition of the rolling deformation zone and the boundary condition. The mechanical parameters were calculated by the analytical method and the numerical method, and the relative deviation is less than 6% which can satisfy the industrial requirement. The present analytical model can predict the characteristics during snake rolling easily and quickly and it is also suitable for online control applications.
Contrast-Enhanced Ultrasound to Monitor Early Recurrence of Primary Hepatocellular Carcinoma after Curative Treatment
Authors: Liu Lian-Feng , Ding Zhan-Ling , Zhong Jian-Hong , Li Hong-Xue , Liu Jun-Jie , Li Hang , Li Le-Qun
Published: November 2018

Objective.To evaluate contrast-enhanced ultrasound (CEUS) for monitoring early intrahepatic recurrence of primary hepatocellular carcinoma (HCC) after curative treatment.Methods.We prospectively analyzed 97 patients (124 nodules) with primary HCC who underwent hepatic resection or radiofrequency ablation and subsequently experienced intrahepatic recurrence. Patients were assessed with conventional ultrasound and CEUS. They were also assessed with contrast-enhanced computed tomography (CECT) and/or magnetic resonance imaging (MRI). The image characteristics of CEUS of recurrent hepatocellular carcinoma and high-grade dysplastic nodules (HGDNs) were analyzed. In addition, the ability of CEUS and CECT/MRI to assess internal artery vascularization in recurrent disease was compared.Results.CEUS of recurrent hepatocellular carcinoma showed hyperenhancement in the arterial phase in 96 of 99 nodules, and it showed hypo- or isoenhancement for portal venous and delayed phases. The most common enhancement patterns were “fast-in and slow-out” and “fast-in and fast-out”. Based on the arterial hyperenhancement of lesions and with clinical data such as patient history of HCC and increased level of serum alpha-fetoprotein, the diagnostic accuracy of CEUS for recurrent HCC was significantly higher than that based on the enhancement pattern of “fast-in and fast-out”. CEUS of HGDNs showed local or global hyperenhancement during the arterial phase, isoenhancement during the portal venous phase, and isoenhancement or slight hypoenhancement during the delayed phase. The enhancement pattern was “fast-in and slow-out”. In some cases, it was difficult to differentiate HGDNs from recurrent disease using CEUS. Vascularization in recurrent disease was significantly higher when assessed by CEUS than when assessed with CECT/MRI (P< 0.05). For detecting recurrent disease, CEUS showed sensitivity of 97.0%, specificity of 68.0%, positive predictive value of 92.3%, and negative predictive value of 85.0%. The corresponding parameters for CECT/MRI were 71.7%, 72.0%, 88.8%, and 39.1%.Conclusion.Intrahepatic recurrent HCC and HGDNs with diameter ≤ 3.0 cm have a characteristic appearance on CEUS. This imaging modality may be effective for monitoring early intrahepatic recurrence after curative treatment of primary HCC.
Perceptual Inhibition Associated with Sensory Integration for Balance in Older Adults
Authors: Redfern Mark S. , Chambers April J. , Sparto Patrick J. , Furman Joseph M. , Jennings J. Richard
Published: November 2018

Aims: Inhibition associated with perception has been implicated in sensory integration processes for balance when sensory conflict occurs. The current study examines the associations of three measures of inhibition (perceptual inhibition, motor inhibition, and Stroop interference) with standing balance under sensory conflict conditions in younger and older adults. Methods: Perceptual inhibition, motor inhibition, and Stroop interference were measured in younger and older subjects. Standing balance under conditions of sensory conflict was evaluated using a modified dynamic posturography protocol. Correlative analysis was performed to examine the associations between the inhibition measures and sway. Results: In older adults only, perceptual inhibition was correlated with sway when sensory conflict was present. Stroop interference and motor inhibition were not significantly correlated with sway under any posturography conditions. Conclusion: Measures of perceptual inhibition are associated with reduced sensory integration capability for balance during sensory conflict conditions in older adults.