bluuebunny/crossref_metadata_2025 huggingface dataset:
Monocyte Chemoattractant Protein‐1, Inflammatory Biomarkers, and Prognosis of Patients With Ischemic Stroke or Transient Ischemic Attack: Fndings From a Nationwide Registry Study
Authors: Xu Qin , Liu Yuanliang , Tian Xue , Xia Xue , Zhang Yijun , Zhang Xiaoli , Wang Yongjun , Sun Ping , Meng Xia , Wang Anxin
Published: August 2024

Background

Recent Mendelian randomization and meta‐analysis highlight the relevance of MCP‐1 (monocyte chemoattractant protein‐1) in stroke. We aimed to investigate the associations between MCP‐1 and clinical outcomes in patients with ischemic stroke or transient ischemic attack and test whether inflammation mediates or jointly contributes to the relationships.

Methods and Results

A total of 10 700 patients from the Third China National Stroke Registry study were included. Multivariable Cox regression was used for recurrent stroke and all‐cause death, and logistic regression was used for poor functional outcome. Mediation analyses were performed to clarify whether inflammation mediates the associations. After adjusting for potential confounders, low MCP‐1 level (<337.6 pg/mL) was associated with a reduced risk of all‐cause death (hazard ratio [HR], 0.65 [95% CI, 0.51–0.82]) and poor functional outcome (odds ratio, 0.81 [95% CI, 0.70–0.94]) but was not associated with recurrent stroke (HR, 1.10 [95% CI, 0.95–1.27]), compared with high MCP‐1 level (≥337.6 pg/mL). The association between MCP‐1 and all‐cause death was partially mediated by highly sensitive C‐reactive protein, interleukin‐6, and YKL‐40 (Chitinase‐3‐like protein 1; mediated proportion: 7.4%, 10.5%, and 7.4%, respectively). The corresponding mediated proportion for poor functional outcome was 9.9%, 17.1%, and 7.1%, respectively. Patients with combined high levels of MCP‐1 and inflammatory biomarkers had the highest risks of all‐cause death and poor functional outcome.

Conclusions

Low plasma MCP‐1 level was associated with decreased risks of all‐cause mortality and poor functional outcome after ischemic stroke or transient ischemic attack. Inflammation partially mediated and jointly contributed to the associations.
A review of the genus Polemistus de Saussure (Hymenoptera: Crabronidae) with the description of a new species from India
Authors: RAJAN TESSY , KUMAR P. GIRISH , SURESHAN P.M. , HEGDE V.D.
Published: August 2024

A review of the genus Polemistus de Saussure has resulted in identifying and describing a new species from Kerala viz., P. jaferi Tessy, Girish Kumar & Sureshan sp. nov. A key to species of Polemistus from the Indian subcontinent is provided.
Semiquantitative assessment of phosphatase and tensin homolog value with immunohistochemistry in colorectal cancer
Authors: Jeo Wifanto S. , Lalisang Toar J.M. , Siregar Nurjati C. , Sudoyo Aru W. , Pakasi Trevino , Jusman Sri W. , Asmarinah Asmarinah
Published: August 2024

Introduction

Colorectal cancer has emerged as a concerning health problem, ranking the third most common form of cancer in both men and women. The phosphatase and tensin homologue (PTEN) protein is widely known for its role as an inhibitor of the phosphatidylinositol 3-kinase/protein kinase-B/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway, playing a major role inhibiting tumor development. Previous studies investigated the role of this protein in the PI3K pathway and how it affected colorectal cancer. However, a standardized cut-off value for PTEN expression has not been established.

Methods

Immunohistochemistry was used in examining PTEN. The staining grade ranging from 0 to 3 was then multiplied by the number of 100 cancer cells counted, with total score between 0 and 300. In this study, receiver operating characteristic (ROC) curve was employed to determine the expression cut-off value for PTEN in colorectal cancer.

Results

This study showed statistically significant results ( P < 0.001) in either tumor or non-tumor tissues by using the ROC curve with a cut-off value of 199.0. This study also revealed significant correlation between nodal status with PTEN ( P = 0.008) and stage with PTEN ( P = 0.019) with sensitivity 0.753 and specificity 0.728.

Conclusion

Semiquantitative assessment with cell counting multiplied by color intensity is a good method in determining PTEN expression. The use of immunohistochemical staining intensity and cell scoring with ROC cut-off is effective to elaborate the effects of PTEN in colorectal cancer (PTEN value > 199.0 was classified as strong and ≤ 199.0 as weak).
Dr Catherine Chisholm, ‘children's physician’: Her work for child welfare and feminist networking in Manchester
Authors: Mohr Peter Dean
Published: August 2024

Catherine Chisholm BA MB ChB MD FRCP CBE (1879–1952) is celebrated as the first woman to qualify in medicine from Manchester University in 1904 and is remembered for founding the Manchester Babies Hospital in 1914 (later renamed in 1935 as the Duchess of York Hospital for Babies). She was indefatigable in her pursuit to improve the education and status of women doctors; the first woman member and president of the British Paediatric Society; first woman president of the Manchester Medical Society and was mainly responsible for establishing the Medical Women's Federation in 1917. Her career was a complex mixture of medical and social networks that linked her work as a children's physician to the Manchester Public Health Committee, Liberal politics and feminist groups. These networks played an important role in Dr Chisholm's successful career and are at the centre of this paper.
Bundling Variety, Usage, or Both? A Multi-Service Analysis of Pay-Per-Use and Subscription Pricing
Authors: Wu Chenguang (Allen) , Jin Chen , Liu Qian
Published: August 2024

We depart from the classic bundling literature on single-unit purchases and develop a multi-unit demand model in which customers decide both the variety and volume of their purchased products. We integrate product bundling with two commonly used usage-based pricing schemes in the service industry, pay-per-use and subscriptions, and examine pricing tactics that span both variety and usage. Our model captures customers’ diminishing margins of consumption, and we demonstrate an intricate interplay between product variety and usage that enriches existing results on the dominance of pure bundling over component selling in the classic single-unit demand model. Specifically, with multi-unit demands, component selling can outperform pure bundling under pay-per-use, whereas the reversal is true under subscriptions. We also analyze mixed bundling (on either variety or usage) and nonlinear pricing, and demonstrate how to leverage these more advanced pricing schemes for better revenues. Our results provide novel insights into firms’ bundling strategies jointly on variety and usage. Collectively, they highlight the critical role of the customer demand model (single-unit vs. multi-unit) in driving monopoly firms’ strategic choice of product (un)bundling.
Struggling with platforms: Marxist identities, cultural production, and everyday work in Brazil
Authors: Karhawi Issaaf , Grohmann Rafael
Published: August 2024

This article analyzes how Marxist platform-dependent cultural producers in Brazil - one woman and two drag queens - navigate platform spaces in relation to their identities and everyday work. Struggling with platforms refers to the specific ways in which Marxist cultural producers seek to engage in class struggles, while also grappling with the constraints imposed by platforms. There are paradoxes, tensions and frictions in these efforts. In analytical terms, the article develops how this ‘struggling with platforms’ occurs in two main dimensions: (1) struggling with identities – including the implications of being a Marxist cultural producer on platforms and how one's identity is shaped and commodified in this space, and (2) struggling with everyday work – considering how the pursuit of social change is both constrained and enabled on platforms.
Supporting Prospective Teachers in Learning Psychology: A Digital Case Exploration Tool
Authors: Scherer Demian , Diekmann Charlotte , Dutke Stephan
Published: August 2024

This article describes the implementation of a digital case-exploration tool and its use in teacher education. The cases were constructed according to empirically based psychological theories and represent school-related scenarios in which the students could choose among options for action. After selecting an action, its psychological consequences are presented in text or video including theoretical explanations how and why the selected action would lead to the presented consequences. We present first quasi-experimental evaluation data demonstrating the tool's usefulness regarding learning outcomes, students’ active participation, and motivation.
RNA-seq reveals the gene expression in patterns in Populus × euramericana 'Neva' plantation under different precision water and fertilizer-intensive management
Authors: Wang Zhou , Zhang Weixi , Ding Changjun , Xia Yongxiu , Yuan Zhengsai , Guo Jiangtao , Yu Jinjin , Zhang Bingyu , Su Xiaohua
Published: August 2024

Background

Populus spp. is a crucial fast-growing and productive tree species extensively cultivated in the mid-latitude plains of the world. However, the impact of intensive cultivation management on gene expression in plantation remains largely unexplored.

Results

Precision water and fertilizer-intensive management substantially increased key enzyme activities of nitrogen transport, assimilation, and photosynthesis (1.12–2.63 times than CK) in Populus × euramericana 'Neva' plantation. Meanwhile, this management approach had a significant regulatory effect on the gene expression of poplar plantations. 1554 differential expression genes (DEGs)were identified in drip irrigation (ND) compared with conventional irrigation. Relative to ND, 2761–4116 DEGs, predominantly up-regulated, were identified under three drip fertilization combinations, among which 202 DEGs were mainly regulated by fertilization. Moreover, drip irrigation reduced the expression of cell wall synthesis-related genes to reduce unnecessary water transport. Precision drip and fertilizer-intensive management promotes the synergistic regulation of carbon and nitrogen metabolism and up-regulates the expression of major genes in nitrogen transport and assimilation processes (5 DEGs), photosynthesis (15 DEGs), and plant hormone signal transduction (11 DEGs). The incorporation of trace elements further enhanced the up-regulation of secondary metabolic process genes. In addition, the co-expression network identified nine hub genes regulated by precision water and fertilizer-intensive management, suggesting a pivotal role in regulating the growth of poplar.

Conclusion

Precision water and fertilizer-intensive management demonstrated the ability to regulate the expression of key genes and transcription factor genes involved in carbon and nitrogen metabolism pathways, plant hormone signal transduction, and enhance the activity of key enzymes involved in related processes. This regulation facilitated nitrogen absorption and utilization, and photosynthetic abilities such as light capture, light transport, and electron transport, which faintly synergistically regulate the growth of poplar plantations. These results provide a reference for proposing highly efficient precision intensive management to optimize the expression of target genes.
A scoping review of policies to encourage breastfeeding, healthy eating, and physical activity among rural people and places in the United States
Authors: Umstattd Meyer M. Renée , Houghtaling Bailey , Wende Marilyn E. , Kheshaifaty Khawlah H. , Delgado Haley , Eze Stephanie A. , Mecate Cassady , Summerall Woodward Rebekah , Morgan Randa Lopez , Krey Kathy J.
Published: August 2024

Background

Rural U.S. residents experience a disproportionate burden of diet and physical activity (PA) related chronic disease compared to urban residents, due to resource and economic challenges. Diverse policy approaches for chronic disease prevention have been implemented to address barriers to breastfeeding, healthy eating, and PA. Therefore, the purpose of this paper is to describe policy supports for breastfeeding, healthy eating, and/or PA occurring in rural U.S. areas.

Methods

A scoping review was conducted March-June 2020 to identify policy, systems, and environment change approaches occurring in the rural U.S. for breastfeeding, healthy eating, and PA. Search procedures were guided by the PRISMA-ScR, Arksey and O’Malley’s work (2007), and a science librarian. Medline, PubMed, Web of Science, and Agricola were used to identify peer-reviewed research. ProQuest Dissertations and Theses A&I were used to identify dissertation research. Grey literature searches included Google, Google Scholar, government pages, and public health, federal nutrition assistance program, Cooperative Extension Services, and related webpages. Policy results are reported and inclusion criteria were: (1) breastfeeding, healthy eating, and/or PA focus; (2) about policy factors; (3) specific to U.S. rural populations/places; and (4) English language. Outcomes (study/source design, objective(s), methods/measurement, setting, population characteristics, behavioral focus, policy-specific results) were extracted into a standardized Excel document.

Results

Results include 122 total sources: original research, with some sources referencing multiple behaviors, (n = 74 sources: 8 breastfeeding, 41 healthy eating, 42 PA), grey literature (n = 45 sources: 16 breastfeeding, 15 healthy eating, 27 PA), and graduate research(n = 3 sources: 1 breastfeeding, 2 healthy eating, 1 PA). Breastfeeding policy initiatives included policies or programs at hospitals, increasing access to resources, and improving culture or norms at workplaces. Healthy eating policy initiatives included increasing access to healthy foods, reducing financial burden, implementing programs, food assistance programs, and healthy food prescriptions at healthcare facilities. PA policy initiatives focused on Complete Streets, joint or shared use efforts, Safe Routes to Schools, master plans for greenways, trails, and/or transportation, school health plans, and childcare/school standards.

Conclusions

Results from this scoping review compile and offer commentary on existing policy solutions to improve breastfeeding, healthy eating, and/or PA in the rural U.S.
Risk prediction model of impacted supernumerary tooth-associated root resorption in children based on cone-beam computed tomography analysis: a case control study
Authors: Li Yakang , Zhang Yuanmin , Gao Linpei , Lyu Menghao , Zheng Baozhu , Zhang Fengqiu , Xu Junji
Published: August 2024

Background

External surface resorption is pressure-induced resorption and occurs on the external surface of the root, pressure exerted by impacted teeth, is common causes of external surface resorption. Predictive risk factors of impacted supernumerary tooth-associated root resorption (ISTARR) mentioned in this article include supernumerary teeth and patient factors. To investigate the risk factors of impacted supernumerary tooth-associated root resorption and predict the incidence of root resorption.

Methods

This restrospective study enrolled 324 patients with impacted supernumerary tooth. All Cone-Beam Computed Tomography (CBCT) data and patient information were divided into two groups (without tooth root resorption and with root resorption). CBCT images and patient information (age and gender) of 133 patients had adjacent tooth root resorption and 191 did not. seven variables were analysed using binary logistic regression.

Results

Individual analysis of potential risk factors showed that age, crown mesiodistal direction, root formation, and odontotheca of the impacted supernumerary tooth were associated significantly with ISTARR. Binary logistic regression showed that impacted supernumerary tooth with odontotheca (Odd Ratio = 2.926), the crown is in the middle (Odd Ratio = 1.446), located at the middle third of the adjacent tooth root (Odd Ratio = 1.614), complete root development (Odd Ratio = 1.334), and patient’s age (Odd Ratio = 1.261) were significantly associated with ISTARR risk.

Conclusions

The risk factors of root resorption can be detected and predicted early according to the features of supernumerary tooth and patient’s age. Still, more prospective studies with larger sample size are needed to validate the result.
Evaluation of the antibacterial and antifungal properties of oleuropein, olea Europea leaf extract, and thymus vulgaris oil
Authors: Al-Rimawi Fuad , Sbeih Mahmood , Amayreh Mousa , Rahhal Belal , Mudalal Samer
Published: August 2024

Background

Although synthetic preservatives and antioxidants may have high antimicrobial and antioxidant activity, they are usually associated with adverse effects on human health. Currently, there is a growing interest in natural antimicrobial and antioxidant agents. This study aimed to evaluate the antimicrobial activity of two medicinal plant extracts and one active compound. Olive leaf extracts (0.2, 0.3, and 0.4% w/v), oleuropein (0.2, 0.4, and 0.6% w/v), thyme oil (0.1%), and oleuropein in combination with thyme oil (0.4% w/v and 0.1% v/v) were used against three bacterial strains (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus) and two fungal strains (Candida albicans and Aspergillus niger).

Results

The use of oleuropein resulted in complete antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. In this context, a reduction of 7 logs was achieved during the storage period (4 weeks). Oleuropein showed no fungal activity at low concentrations (0.2%), but Aspergillus niger was reduced by 2.35 logs at higher concentrations (0.6% w/v). Similar antibacterial and antifungal properties were observed for the olive leaf extracts. Oleuropein at a concentration of 0.4 w/v and a mixture of oleuropein and thyme at concentrations of 0.4 and 0.1 (v/v) showed strong antimicrobial activity against the studied microorganisms.

Conclusion

Olive leaf extract, thyme oil, and oleuropein have strong antibacterial and weak antifungal properties. There was a good synergistic effect between oleuropein and thymol.
Treatment and management of coenurosis by Taenia multiceps: field data from outbreaks in endemic regions and literature review
Authors: Abbas I. , Tamponi C. , Madau G. , Cavallo L. , Varcasia A. , Scala A.
Published: August 2024

Background

Taenia multiceps coenurosis is endemic in sheep from various regions worldwide. Dogs, the key hosts, shed T. multiceps eggs in their feces contaminating the pasture, and lambs are mostly infected during their first turnout into pastures. The disease is manifested in two forms: acute (due to the migrating oncospheres in the CNS) or chronic (due to the developing coenuri in the brain or spinal cord). Both forms are frequently accompanied by neurological symptoms.

Methods

Field trials conducted in an endemic region (Sardinia, Italy) to treat replacement lambs in six sheep flocks infected with acute coenurosis are summarized in this article. The article also reviews earlier reports on various approaches developed to treat and immunize sheep against coenurosis.

Results

Accurate detection of the time in which lambs become infected is crucial in deciding which treatment approach should be used. Acute disease can be successfully treated via chemotherapy. Results of field trials conducted in Sardinia revealed the efficacy of three (1-week apart) oxfendazole doses (14.15 mg/kg) in protecting apparently healthy lambs in the infected flocks from developing neurological symptoms. A single praziquantel dose (18.75 mg/kg) worked well for the same purpose and was also found significant in treating 5 of 16 clinically ill lambs in one flock. Earlier reports documented high rates of recovery (up to 100%) in clinically diseased lambs that received much higher doses (50–100 mg/kg) of praziquantel. However, chemotherapy is not preferred in chronic coenurosis since it can lead to rupture of the coenuri, giving rise to serious inflammation in the CNS. Surgical intervention is highly recommended in this case, and the pooled success rates for surgery in chronic-infected cases was estimated at 82.1% (95% CI 73.1–91.0%). However, various trials have been conducted to immunize sheep against T. multiceps coenurosis, and the 18k (Tm18) family of oncosphere antigens was found promising as a vaccine candidate.

Conclusions

In acute coenurosis, selection of the proper anthelmintic should be done after consulting the owner for several reasons: (1) costs of the used anthelmintic: treating a small flock of 100 sheep costs around 1170 and 660 € for praziquantel and oxfendazole, respectively; (2) withdrawal time of the used anthelmintic: No time is required before consuming meat and milk from praziquantel-treated sheep, whereas meat and milk from oxfendazole-treated sheep should not be consumed for 44 and 9 days, respectively, causing additional costs for the farmers. Since no commercial vaccines have yet been developed against T. multiceps coenurosis in sheep, preventive measures remain the cornerstone of controlling this serious disease.

Graphical Abstract
The genetics and epidemiology of N- and O-immunoglobulin A glycomics
Authors: Visconti Alessia , Rossi Niccolò , Bondt Albert , Ederveen Agnes Hipgrave , Thareja Gaurav , Koeleman Carolien A. M. , Stephan Nisha , Halama Anna , Lomax-Browne Hannah J. , Pickering Matthew C. , Zhou Xu-jie , Wuhrer Manfred , Suhre Karsten , Falchi Mario
Published: August 2024

Background

Immunoglobulin (Ig) glycosylation modulates the immune response and plays a critical role in ageing and diseases. Studies have mainly focused on IgG glycosylation, and little is known about the genetics and epidemiology of IgA glycosylation.

Methods

We generated, using a novel liquid chromatography-mass spectrometry method, the first large-scale IgA glycomics dataset in serum from 2423 twins, encompassing 71 N- and O-glycan species.

Results

We showed that, despite the lack of a direct genetic template, glycosylation is highly heritable, and that glycopeptide structures are sex-specific, and undergo substantial changes with ageing. We observe extensive correlations between the IgA and IgG glycomes, and, exploiting the twin design, show that they are predominantly influenced by shared genetic factors. A genome-wide association study identified eight loci associated with both the IgA and IgG glycomes (ST6GAL1, ELL2, B4GALT1, ABCF2, TMEM121, SLC38A10, SMARCB1, and MGAT3) and two novel loci specifically modulating IgA O-glycosylation (C1GALT1 and ST3GAL1). Validation of our findings in an independent cohort of 320 individuals from Qatar showed that the underlying genetic architecture is conserved across ancestries.

Conclusions

Our study delineates the genetic landscape of IgA glycosylation and provides novel potential functional links with the aetiology of complex immune diseases, including genetic factors involved in IgA nephropathy risk.
SGLT2 inhibitors: a novel therapy for cognitive impairment via multifaceted effects on the nervous system
Authors: Mei Jiaqi , Li Yi , Niu Liyan , Liang Ruikai , Tang Mingyue , Cai Qi , Xu Jingdong , Zhang Deju , Yin Xiaoping , Liu Xiao , Shen Yunfeng , Liu Jianping , Xu Minxuan , Xia Panpan , Ling Jitao , Wu Yuting , Liang Jianqi , Zhang Jing , Yu Peng
Published: August 2024

The rising prevalence of diabetes mellitus has casted a spotlight on one of its significant sequelae: cognitive impairment. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally developed for diabetes management, are increasingly studied for their cognitive benefits. These benefits may include reduction of oxidative stress and neuroinflammation, decrease of amyloid burdens, enhancement of neuronal plasticity, and improved cerebral glucose utilization. The multifaceted effects and the relatively favorable side-effect profile of SGLT2 inhibitors render them a promising therapeutic candidate for cognitive disorders. Nonetheless, the application of SGLT2 inhibitors for cognitive impairment is not without its limitations, necessitating more comprehensive research to fully determine their therapeutic potential for cognitive treatment. In this review, we discuss the role of SGLT2 in neural function, elucidate the diabetes-cognition nexus, and synthesize current knowledge on the cognitive effects of SGLT2 inhibitors based on animal studies and clinical evidence. Research gaps are proposed to spur further investigation.
Untargeted lipidomics reveals racial differences in lipid species among women
Authors: Pourali Ghazaleh , Li Liang , Getz Kayla R. , Jeon Myung Sik , Luo Jingqin , Luo Chongliang , Toriola Adetunji T.
Published: August 2024

Understanding the biological mechanisms underlying racial differences in diseases is crucial to developing targeted prevention and treatment. There is, however, limited knowledge of the impact of race on lipids. To address this, we performed comprehensive lipidomics analyses to evaluate racial differences in lipid species among 506 non-Hispanic White (NHW) and 163 non-Hispanic Black (NHB) women. Plasma lipidomic profiling quantified 982 lipid species. We used multivariable linear regression models, adjusted for confounders, to identify racial differences in lipid species and corrected for multiple testing using a Bonferroni-adjusted p-value < 10–5. We identified 248 lipid species that were significantly associated with race. NHB women had lower levels of several lipid species, most notably in the triacylglycerols sub-pathway (N = 198 out of 518) with 46 lipid species exhibiting an absolute percentage difference ≥ 50% lower in NHB compared with NHW women. We report several novel differences in lipid species between NHW and NHB women, which may underlie racial differences in health and have implications for disease prevention.
Regulating Abortion Later in Pregnancy: Fetal-Centric Laws and the Erasure of Women's Subjectivity
Authors: Kimport Katrina , Weitz Tracy A.
Published: August 2024

Context: In the United States, fetal development markers, including “viability” and the point when a fetus can “feel pain,” have permeated the social imaginary of abortion, affecting public support for abortion and the legality and availability of care, but the extent to which these markers describe and orient the experience of abortion at later gestations is unclear.

Methods: Using interviews with 30 cisgender women in the United States who obtained an abortion after 24 weeks of pregnancy, the authors investigated whether and how notions of fetal viability and/or pain operated in the women's lived experiences of pregnancy and abortion.

Findings: According to respondents’ accounts, fetal development–based laws restricting abortion based on purported points of fetal development operated as gestational limits, privileged the viability and pain status of the fetus over that of the prospective neonate, and failed to account for the viability and pain of the pregnant person.

Conclusions: The discursive practice of centering fetal development in regulating abortion access makes denial of abortion care because of the fetus's status conceptually available—even at the point of fertilization—and naturalizes the erasure of the subjectivity of women and others who can become pregnant.
Client-Server Code Mobility at Runtime
Authors: Heil Sebastian , Schröder Lucas , Gaedke Martin
Published: August 2024

Application logic is inherently distributed between client and server due to the fundamental Client/Server architecture of the Web. The individual distribution is specified at design time and remains unchanged stable, preventing individual load distribution between clients and server at runtime. Dynamic code mobility at runtime, in contrast, allows to balance the needs of users, through increased responsiveness, and software providers, through better resource usage and cost reductions. Enabled by WebAssembly, the Web ecosystem recently provides the technological foundation for relocating code units during runtime. However, leveraging these capabilities to enhance web applications with dynamic code migration presents challenges for web engineers. In response, we propose an innovative distributed Client/Server software architecture for web applications. This architecture facilitates the dynamic migration of code at runtime, and addresses the technical challenges like dependency management, control and data flow distribution, communication, and interfaces. This novel software architecture serves as a reference for web engineers aiming to enrich their web applications with dynamic code mobility. Additionally, it contributes to the ongoing reevaluation of the Web ecosystem in light of the widespread adoption and standardization of WebAssembly across major browsers. Through experimentation in four scenarios, we demonstrate the feasibility of implementing this architecture, its negligible impact on performance and the optimization potential for individual code distributions across client and server.
Integration of an Open Source Identity Management System in Educational Platforms
Authors: Barra Enrique , Pozo Alejandro , López-Pernas Sonsoles , Alonso Alvaro , Gordillo Aldo
Published: August 2024

Making research advances available to the community in the shape of open source software has the potential to introduce cutting-edge innovations from early on, foster collaborative development, and revolutionize industrial applications. However, including open source software resulting from a research project as part of a production system poses some risks and must be evaluated in detail, considering all pros and cons. This is especially delicate when that piece of software is in charge of authentication and authorization. This article reports on an experience of integrating open source identity and access management (IAM) software that is the result of multiple research projects, the FIWARE Keyrock IAM, into three educational web-based platforms: two learning object repositories and a course management platform. We intend to draw the lessons learned from this experience so they can guide software practitioners when deciding if they should integrate open source software developed in research projects.
Total Hip Arthroplasty Infection Due to Yersinia enterocolitica: Report of Two Cases and Comprehensive Review of the Literature
Authors:   Université de Tours-Faculty of Medicine, de Tours-CHRU Trousseau Service d’Orthopédie Traumatologie, 37170 Chambray-les-Tours, France,, Martrenchar Paul , Samargandi Ramy ,   [1] Université de Tours-Faculty of Medicine, de Tours-CHRU Trousseau Service d’Orthopédie Traumatologie, 37170 Chambray-les-Tours, France, [2] Department of Orthopedic Surgery, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Published: August 2024

Introduction: Yersinia enterocolitica (is a gram-negative bacillus found in pigs and transmitted orally. It can contaminate a joint prosthesis following bacteremia. It is a potentially fatal and extremely rare infection, with fewer than 10 cases reported in the literature. Case Report: This article describes two cases of patients who had a total hip arthroplasty infection, managed in our department. Both patients underwent emergency surgery for resection arthroplasty antibiotic therapy. Despite early management, both patients were died. Conclusion: It is crucial to consider Yersinia infection in the context of prosthetic joint infection, even years after the operation, especially if it occurs following a digestive pathology. Rapid diagnosis and prompt initiation of appropriate management are essential. Keywords: Prosthetic joint infection, hip arthroplasty, Yersinia enterocolitica, joint infection, postoperative complications.
Complex Interplay: A Gigantic Recurrent Popliteal Cyst Following Total Knee Arthroplasty in a Patient with Refractory Rheumatoid Arthritis Case Report
Authors:   Department of Orthopedic Traumatology Department Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia,, Abualross Osamah , Samargandi Ramy ,   [2] Department of Orthopedic Traumatology, Université de Tours, Faculté de Médecine de Tours – CHRU Trousseau Orthopedic Traumatology Department, Chambray-les-Tours, France, [3] Department of Orthopedic Surgery, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia., Le Nail Louis-Romée ,   Department of Orthopedic Traumatology, Université de Tours, Faculté de Médecine de Tours – CHRU Trousseau Orthopedic Traumatology Department, Chambray-les-Tours, France,, Berhouet Julien ,   Department of Orthopedic Traumatology, Université de Tours, Faculté de Médecine de Tours – CHRU Trousseau Orthopedic Traumatology Department, Chambray-les-Tours, France,
Published: August 2024

Introduction: A popliteal cyst, or Baker’s cyst, is often associated with joint diseases such as osteoarthritis and rheumatoid arthritis (RA). It is rare for these cysts to develop following total knee arthroplasty (TKA), but understanding when and why they might can optimize patient care. Presented here is a unique case of a massive, chronically recurring infected popliteal cyst in a patient with RA and prior TKA, shedding light on an unusual complication worth attention in the orthopedic literature. Case Report: In this case, the patient had longstanding, difficult-to-treat RA. Following left TKA, the patient developed a painful popliteal cyst, leading to hospitalization in 2023. Microbiological analysis identified Staphylococcus lugdunensis as the infectious agent despite negative mycobacterial and mycological cultures. Surgical intervention involved a one-stage procedure, encompassing resection of the extensive thigh cyst and prosthesis replacement. Notably, the cyst reached an unprecedented size, measuring 32 cm at its peak, presenting a unique challenge in management. Conclusion: This case report contributes significantly to orthopedic literature by highlighting the intricate interplay between joint pathologies, surgical interventions, and infections. It highlights the importance of multidisciplinary collaboration in managing complex musculoskeletal conditions. The rarity of a massive and infected popliteal cyst post-TKA emphasizes the need for heightened vigilance in patient care post-surgery. Furthermore, this case report serves as a valuable addition to the understanding of potential complications associated with TKA, offering insights that may inform future treatment strategies and optimize patient outcomes in orthopedic practice. Keywords: Cyst, arthroplasty, infection, knee, post-operative complication, soft-tissue mass.
Atypical Presentation of Primary Greater Trochanter Tuberculosis — A Case Report
Authors:   Department of Orthopaedics, TNMC and B.Y.L Nair Charitable Hospital, Mumbai, Maharashtra, India,, Avhad Tan may , Baharani Ankita ,   Department of Radiology, TNMC and B.Y.L Nair Charitable Hospital, Mumbai, Maharashtra, India., Singh Sushmita ,   Department of Radiology, TNMC and B.Y.L Nair Charitable Hospital, Mumbai, Maharashtra, India., Misal Ankush ,   Department of Orthopaedics, TNMC and B.Y.L Nair Charitable Hospital, Mumbai, Maharashtra, India,, Bengali Yash ,   Department of Orthopaedics, TNMC and B.Y.L Nair Charitable Hospital, Mumbai, Maharashtra, India,
Published: August 2024

Introduction: Tuberculosis (TB) of the greater trochanter constitutes about 2% of musculoskeletal TB cases, often presenting with non-specific symptoms of localized pain, tenderness, and swelling, necessitating differentiation from other conditions like tumors. Bursal involvement results in the formation of a fluctuating mass. This case emphasizes the need for meticulous diagnostic evaluation in these cases due to their uncommon presentation and potential for inadequate assessment. Case Report: A 50-year-old male experienced hip pain and swelling after a trivial fall, leading to surgery for suspected abscess. Despite initial treatment, symptoms persisted which on further imaging suggested TB osteomyelitis that was confirmed on biopsy, prompting 18 months of anti-tubercular therapy. The patient showed significant improvement after a year, highlighting the importance of thorough evaluation and appropriate management in such cases. Conclusion: This case emphasizes the rare occurrence of primary TB in the greater trochanter, advocating for precise diagnosis through advanced imaging. It also underscores the importance of comprehensive TB testing, particularly in extrapulmonary cases which are prevalent in developing nations, to improve treatment outcomes. Keywords: Tuberculosis, greater trochanter, computed tomography-guided biopsy, anti-tubercular drugs.
Bilateral Subluxation of the Proximal Tibiofibular Joint: A Rare Case Report
Authors:   Department of Orthopaedics, Atal Bihari Vajpayee Institute of Medical Sciences, Dr Ram Manohar Lohia Hospital, New Delhi, India,, Arora Rachit , Jain Vijay Kumar ,   Department of Orthopaedics, Atal Bihari Vajpayee Institute of Medical Sciences, Dr Ram Manohar Lohia Hospital, New Delhi, India,, Jeyaraman Madhan ,   Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai, Tamil Nadu, India., Jeyaraman Naveen ,   Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai, Tamil Nadu, India.
Published: August 2024

Introduction: Proximal tibiofibular joint (PTFJ) subluxations are rare and can occur following trauma or sporting events. Idiopathic PTFJ subluxations are more common in females and in patients with generalized ligament laxity. The proper history and clinical examination together with imaging can help in establishing the diagnosis in the majority of cases. Case Report: We report a rare case of bilateral subluxation of PTFJ and describe the detailed clinical features and magnetic resonance imaging findings. The patient was managed conservatively with good results. Conclusion: Bilateral subluxation of the PTFJ is a rare clinical entity often associated with specific demographic and physical characteristics, such as young females engaged in high-impact sports. This case underscores the importance of a thorough clinical and imaging evaluation to differentiate it from other causes of lateral knee pain and prominence. Conservative management, including physical therapy and routine follow-ups, has proven effective in managing symptoms and avoiding progression, highlighting the non-operative approach in treating this condition. Keywords: Proximal tibiofibular joint, subluxation, instability, injury, conservative.
Case Report of Herpes Zoster Infection of the Cervical Dermatome – A Rare Cause of Acute Shoulder Pain
Authors:   Department of Orthopaedic Surgery, Changi General Hospital, Singapore, Singapore,, Aurangzeb Amirzeb , Chong Elliot Yeung ,   Department of Orthopaedic Surgery, Changi General Hospital, Singapore, Singapore,, Yuen Paul Wen Loong ,   Department of Orthopaedic Surgery, Changi General Hospital, Singapore, Singapore,, Koh Don Thong Siang ,   Department of Orthopaedic Surgery, Singapore General Hospital, Singapore, Singapore., Koh Chung Liang ,   Department of Orthopaedic Surgery, Changi General Hospital, Singapore, Singapore,
Published: August 2024

Introduction: Acute shoulder pain is among the most common presenting complaints in the clinic. Clinicians may find it challenging with the myriad of potential etiologies to explain for the presenting complaint. We present a unique case, where a herpes zoster infection in the C6 dermatome mimicked the presentation of rotator cuff pathology and was admitted to the care of orthopedics. We have also included a detailed literature review on the topic in our study. Case Report: The patient was a 38-year-old Chinese female who presented with acute atraumatic right-sided shoulder pain and weakness which was potentially confounded by an attempt of traditional Chinese medicine. Clinical examination revealed that the range of motion was globally reduced and painful in all directions with equivocal impingement testing. Examination of the skin revealed the presence of polymorphous eruption of erythematous papules and vesicles in the right shoulder and C6 region. In this paper, we discuss a possible algorithm to aid clinicians in an acute shoulder pain history with accompanying red flags to look out for. This is accompanied by a detailed literature review on the topic which demonstrates the rarity of this presentation which eventually confounded the initial management of the patient. Conclusion: A thorough history and physical examination must remain the cornerstone of a clinician’s diagnostic algorithm. Zoster neuropathy at the level of the cervical spine is a rare entity. This case report also emphasizes the need for cognizance of local traditional remedies practiced and their interactions with clinical diagnosis and treatment. Keywords: Shoulder, zoster, cervical.
Crip Interventions in Zitkála-Šá's Boarding School Stories
Authors: Wilcox Cowing Jess L.
Published: August 2024

Abstract: Zitkála-Šá (Dakota) narrates the effects of rigid domesticity training in her autobiographical boarding school stories for The Atlantic (1900). This article takes up Zitkála-Šá's boarding school stories alongside turn-of-the-century archival documentation of the federally funded Carlisle Indian Industrial School. Zitkála-Šá's boarding school stories document the disabling and debilitating effects of assimilation training on young Native women and girls. I offer a crip reading of Zitkála-Šá's stories to account for the embodied impact of settler colonial violence carried out through domesticity training in federal off-reservation boarding schools, or what I call "settler ableism."
Embodiment in Anthropological Epigenetics Research
Authors: Saboowala Sana , Wilson Meredith A. , Vilchis Sahara Z. , Rogers-LaVanne Mary P.
Published: August 2024

This article reviews literature in human epigenetic research as a case study in order to examine and critique the dominant framework of embodiment as unidirectional or bidirectional and mechanistically driven. The authors identify three major critiques to this approach: (1) the treatment of epigenetic traits as a mechanism of embodiment, rather than as multidirectional components of a dynamic and ongoing embodiment process; (2) a tendency to view changing epigenetic traits as both the cause and the solution for embodied social inequalities rather than examining the need for systemic change; and (3) a loss of the complexity of varied lived experiences within epigenetic studies. The authors suggest weaving in humanistic frameworks and expanding toward a multidirectional definition of embodiment in the field as a way forward.
A mesoscopic axially swept oblique plane microscope for imaging of freely moving organisms with near-isotropic resolution
Authors: Prevedel Robert , Davis Samuel , Sommernes Jon-Richard , Hambura Sebastian , Riedel Levin , Gil Alejandro , Ikmi Aissam , Stroehl Florian
Published: August 2024

Rapid three-dimensional imaging over extended fields of views (FOVs) is crucial to the study of organism-wide systems and biological processes in vivo. Selective-plane illumination microscopy (SPIM) is a powerful method for high spatio-temporal resolution in toto imaging of such biological specimens. However, typical SPIM implementations preclude conventional sample mounting and have anisotropic imaging performance, in particular when designed for large FOVs over 1 mm diameter. Here, we introduce axial sweeping of the illumination into a non-orthogonal dual-objective oblique plane microscope (OPM) design, thereby enabling the observation of freely moving animals over millimeter sized FOVs, at close to isotropic, sub-cellular resolution. We apply our mesoscopic axially swept OPM (MASOPM) to imaging the behavioral dynamics of the sea anemone Nematostella vectensis over 1 × 0.7 × 0.4 mm at 1.7 × 2.6 × 3.7 µm resolution and 0.5 Hz volume rate.
Translation and interpreting teachers’ perceptions of dilemma and needs in their professional development
Authors: Liu Yi , Liu Jianyu
Published: August 2024

Since Chinese universities launched the postgraduate program of the Master of Translation and Interpreting (MTI) in 2007, approximately 300 high education institutions in China have been authorized to offer the MTI program. Behind the drastic springing-up of MTI programs during the decade, MTI teachers’ professional development draws the attention of MTI administrators and researchers. This study adopted a mixed-method of a large-scale survey among 514 MTI teachers across China and a qualitative interview study of seven participants and discussed MTI teachers’ perceptions of dilemmas and inner-world needs in their professional development. The findings indicate that MTI teachers’ dilemmas arise from the contradiction and entanglement in three mutually repulsive sectors of their professional development, i.e., teaching, research, and translation/interpreting practice, which hinder their professional development. And on the basis of the analysis, the present study proposes a synchronized “three-in-one” mechanism model with encouraging policies and environments as lubricant for the sustainable development of MTI teachers in the future, and it is hoped that this empirical research would provide some practice implications for the professional development of translation and interpreting teachers in China and beyond.
Association of gut microbiota with depression post-myocardial infarction: A systematic evaluation and meta-analysis protocol
Authors: Liu Xiang , Shi Xiaojun , Zhao Haibin , Hou Jiqiu , Zhao Weizhe , Ding Wanli
Published: August 2024

Background

Depression post-myocardial infarction (MI) is becoming more prevalent. The gut-brain axis (GBA), influenced by the gut microbiota, is a critical component in understanding depression post-MI. Despite the well-established connection between gut microbiota and depression post-MI, this relationship remains incompletely understood.

Methods and analysis

This protocol will follow the Preferred Reporting Items for Systematic Review and Meta-analysis Protocol (PRISMA-P) 2020 statement. Beginning from inception to October 2023, a systematic search will be conducted across eight electronic databases, including PubMed, MEDLINE, Scopus, Embase, Cochrane Clinical Trials Database, Web of Science, China National Knowledge Infrastructure, and China Biomedical Literature Database. Pre-selected studies will be independently assessed by two researchers following a standard inclusion, data extraction and quality assessment protocol. The primary outcome measures are differences in the profile of gut microbiota and rating scale scores for depression. Fixed-effects models will be used when both clinical heterogeneity and statistical heterogeneity are low, otherwise random-effects models will be used. Furthermore, subgroup analyses will be conducted on the depression severity of the participants using the same psychiatric scales employed, study type and geographic region. Random forest plot runs and research-related statistical analyses will be carried out using Rev Man V.5.3 software.

Expected results

This study will identify the association between the gut microbiota and the onset of depression post-MI, and provide evidence for the use of probiotics as an adjunctive treatment for depression post-MI.

Trial registration

Prospero registration number: CRD42023444026.