bluuebunny/crossref_metadata_2025 huggingface dataset:
A time motion study of manual versus artificial intelligence methods for wound assessment
Authors: Mohammed Heba Tallah , Bartlett Robert L. , Babb Deborah , Fraser Robert D. J. , Mannion David
Published: July 2022

Objectives

This time-motion study explored the amount of time clinicians spent on wound assessments in a real-world environment using wound assessment digital application utilizing Artificial Intelligence (AI) vs. manual methods. The study also aimed at comparing the proportion of captured quality wound images on the first attempt by the assessment method.

Methods

Clinicians practicing at Valley Wound Center who agreed to join the study were asked to record the time needed to complete wound assessment activities for patients with active wounds referred for a routine evaluation on the follow-up days at the clinic. Assessment activities included: labelling wounds, capturing images, measuring wounds, calculating surface areas, and transferring data into the patient’s record.

Results

A total of 91 patients with 115 wounds were assessed. The average time to capture and access wound image with the AI digital tool was significantly faster than a standard digital camera with an average of 62 seconds (P<0.001). The digital application was significantly faster by 77% at accurately measuring and calculating the wound surface area with an average of 45.05 seconds (P<0.001). Overall, the average time to complete a wound assessment using Swift was significantly faster by 79%. Using the AI application, the staff completed all steps in about half of the time (54%) normally spent on manual wound evaluation activities. Moreover, acquiring acceptable wound image was significantly more likely to be achieved the first time using the digital tool than the manual methods (92.2% vs. 75.7%, P<0.004).

Conclusions

Using the digital assessment tool saved significant time for clinicians in assessing wounds. It also successfully captured quality wound images at the first attempt.
Usability of German hospital administrative claims data for healthcare research: General assessment and use case of multiple myeloma in Munich university hospital in 2015–2017
Authors: AlZahmi Amal , Cenzer Irena , Mansmann Ulrich , Ostermann Helmut , Theurich Sebastian , Schleinkofer Tobias , Berger Karin
Published: July 2022

Objectives

To assess the usability of German hospital administrative claims data (GHACD) to determine inpatient management patterns, healthcare resource utilization, and quality-of-care in patients with multiple myeloma (PwMM).

Methods

Based on German tertiary hospital’s claims data (2015–2017), PwMM aged >18 years were included if they had an International Classification of Diseases, Tenth Revision, code of C90.0 or received anti-MM therapy. Subgroup analysis was performed on stem cell transplantation (SCT) patients.

Results

Of 230 PwMM, 59.1% were men; 56.1% were aged ≥65 years. Hypertension and infections were present in 50% and 67.0%, respectively. Seventy percent of PwMM received combination therapy. Innovative drugs such as bortezomib and lenalidomide were given to 36.1% and 10.9% of the patients, respectively. Mean number of admissions and mean hospitalization length/patient were 3.69 (standard deviation (SD) 2.71 (1–16)) and 12.52 (SD 9.55 (1–68.5)) days, respectively. In-hospital mortality was recorded in 12.2%. Seventy-two percent of SCT patients (n = 88) were aged ≤65 years, 22.7% required second transplantation, and 89.8% received platelet transfusion at a mean of 1.42(SD 0.63 (1–3)).

Conclusion

GHACD provided relevant information essential for healthcare studies about PwMM from routine care settings. Data fundamental for quality-of-care assessment were also captured.
Psychosocial interventions and mental health in patients with cardiovascular diseases living in low and middle-income countries: A systematic review protocol
Authors: Hirani Saima , Gowani Ambreen , Sajjad Sehrish , Kennedy Megan , Norris Colleen M.
Published: July 2022

Objective

The objective of this review is to evaluate the effectiveness of psychosocial interventions on mental health outcomes in adult patients with Cardiovascular Diseases (CVDs) living in low- and middle-income countries (LMICs).

Introduction

Mental health issues are highly prevalent among patients with CVDs leading to poor disease prognosis, self-care/ management, and Quality of Life (QOL). In the context of LMICs, where the disease burden and treatment gap are high and resources are inadequate for accessing essential care, effective psychosocial interventions can make significant contributions for improving mental health and reducing mental health problems among patients who live with cardiovascular diseases.

Inclusion criteria

This review will include studies published between 2010 and 2021 that evaluated the effect of psychosocial interventions on mental health outcomes (resilience, self-efficacy, QOL, depression and anxiety) on adult patients (aged ≥18 years) with any cardiovascular diseases using experimental and quasi experimental designs.

Methods

The search will be conducted from the following databases: MEDLINE via OVID (1946—Present), EMBASE via OVID (1974 –Present), Cumulative Index for Nursing and Allied Health Literature (CINAHL) via EBSCOhost (1936—Present), PsycINFO via OVID (1806—Present), Scopus via Elsevier (1976—Present), and Cochrane Library via Wiley (1992—Present). Data will be critically appraised using standard tools and extracted by two reviewers and disagreement will be solved by the third reviewer. Meta-analysis will be performed, if possible, otherwise, data will be synthesized in narrative and tabular forms.

Discussion

The findings of this review will provide a key insight into contextually relevant psychosocial interventions for promoting mental health of patients with CVDs living in LMICs. The review findings will be potentially useful for health care providers and researchers to implement such interventions not only for reducing the burden of mental health issues but also for improving the overall well-being among patients with chronic illnesses.

Systematic review registration number

Prospero-CRD42020200773.
The impact of retinal fluid tolerance on the outcomes of neovascular age-related macular degeneration treated using aflibercept: A real-world study
Authors: Jeng Yu-Ting , Lai Tso-Ting , Lin Chao-Wen , Chen Ta-Ching , Hsieh Yi-Ting , Lin Chang-Ping , Ho Tzyy-Chang , Yang Chung-May , Yang Chang-Hao
Published: July 2022

This study investigated the impact of retinal fluid tolerance on retinal thickness and visual acuity in patients with neovascular age-related macular degeneration after 18 months of treatment using intravitreal aflibercept. This retrospective study was based on the medical records of 90 eyes presenting persistent or recurrent retinal fluid retention after 3 months of aflibercept loading injections. We defined the fluid tolerance ratio as the sum of fluid-tolerance duration divided by the total duration of retinal fluid observed throughout the follow-up period. Eyes were categorized into strict, intermediate, and relaxed group based on their fluid tolerance ratio (= 0, <30%, > = 30%, respectively). The mean total follow-up time was 556 days. The relaxed group required fewer injections than the strict group (4.92 vs 7.50 injections, P < 0.01) and presented a similar reduction in retinal thickness (-57.50 vs -71.65 μm, P = 0.83). Nonetheless, the two groups were similar in terms of final visual acuity (logarithm of the minimum angle of resolution 0.72 vs 0.70, P = 0.95) and visual gains (4.21 vs -1.12 letters, P = 0.56). These results indicate that in the setting of limited medical resources, a fluid-tolerant approach provides comparable gains in visual acuity. Reducing the number of injections may also improve adherence to therapy.
Mesostats—A multiplexed, low-cost, do-it-yourself continuous culturing system for experimental evolution of mesocosms
Authors: Hansson Erika M. , Childs Dylan Z. , Beckerman Andrew P.
Published: July 2022

Microbial experimental evolution allows studying evolutionary dynamics in action and testing theory predictions in the lab. Experimental evolution in chemostats (i.e. continuous flow through cultures) has recently gained increased interest as it allows tighter control of selective pressures compared to static batch cultures, with a growing number of efforts to develop systems that are easier and cheaper to construct. This protocol describes the design and construction of a multiplexed chemostat array (dubbed “mesostats”) designed for cultivation of algae in 16 concurrent populations, specifically intended for studying adaptation to herbicides. We also present control data from several experiments run on the system to show replicability, data illustrating the effects of common issues like leaks, contamination and clumps, and outline possible modifications and adaptations of the system for future research.
Anatomical contribution of the orbicularis oculi to the zygomaticus major: An improved understanding of the smile with consideration for facial cosmetic procedures
Authors: Iwanaga Joe , Hur Mi-Sun , Kikuta Shogo , Ibaragi Soichiro , Watanabe Koichi , Tubbs R. Shane
Published: July 2022

The aim of the present study was to determine the contribution of the orbicularis oculi (OOc) to the zygomaticus major (Zmj) in connecting the orbital region to the corner of the mouth. The OOc and Zmj of 22 embalmed adult Korean cadavers were dissected in 44 hemifaces. The OOc fibers were traced to determine their contribution to the Zmj. Parts of the superficial bundle in the orbital region of the OOc extended directly or indirectly to the Zmj in 22.7% of the specimens. The anatomical contribution of the OOc to the Zmj was divided into three categories depending on whether the connection between them was direct or indirect: (1) superficial orbital OOc fibers extended directly to the Zmj in 6.8% of the specimens, (2) superficial orbital OOc fibers extended to the zygomaticus minor and their small portion joined to the upper fibers of the Zmj in 15.9% of the specimens, and (3) no connection was identified between the OOc and Zmj in 77.3% of the specimens. The results of this study provide further anatomical insight into the relationship between the OOc and zygomaticus muscle complex. This information could be helpful for elucidating the anatomy of smiling and treatment and surgery designs for balanced or ideal smiles.
Optimal duration of the apnea test for determining brain death: Benefit of the short-term apnea test
Authors: Baik Seung Min , Park Jin , Kim Tae Yoon , Hong Kyung Sook
Published: July 2022

Background

The criteria for brain death determination have not been unified globally, and there is no global consensus on the apnea test, which is essential for determining brain death. Since the apnea test is associated with many complications, we aimed to determine an optimal duration of the apnea test.

Methods

We analyzed the results of the apnea test performed for brain death determination between August 2013 and February 2021 at a single institution in South Korea. Elevations in the partial pressure of carbon dioxide and mean arterial blood pressure fluctuations over time in the apnea test were recorded.

Results

In the 1st and 2nd tests, the mean partial pressure of carbon dioxide increased by more than 20 mmHg at 3 min after the apnea test compared to before the test (P < 0.05). At 4 min in the 1st test and 5 min in the 2nd test, the partial pressure of carbon dioxide exceeded 60 mmHg (P < 0.05). The fluctuation in the mean arterial blood pressure observed for 5 min during the apnea test was not significant. There was no significant fluctuation in the mean arterial blood pressure over time in the apnea test between patients with normal chest radiography findings and those with abnormal chest radiography findings (P = 0.888).

Conclusions

Our study proposes that a short-term apnea test protocol is valid for the preservation of organs for donation.
Spatial and temporal distribution of the prevalence of unemployment and early retirement in people with multiple sclerosis: A systematic review with meta-analysis
Authors: Vitturi Bruno Kusznir , Rahmani Alborz , Dini Guglielmo , Montecucco Alfredo , Debarbieri Nicoletta , Bandiera Paolo , Battaglia Mario Alberto , Manacorda Tommaso , Persechino Benedetta , Buresti Giuliana , Ponzio Michela , Inglese Matilde , Durando Paolo
Published: July 2022

Background

We aimed to summarise the prevalence of unemployment and early retirement among people with MS and analyze data according to a spatio-temporal perspective.

Methods

We undertook a systematic search of PubMed/MEDLINE, Scopus, SciVerse ScienceDirect, and Web of Science. We included any peer-reviewed original article reporting the prevalence of unemployment and early retirement in the working-age population with MS. We excluded articles off-topic, with other study designs, whose study sample were unlikely to be representative of the MS population and in case of unavailability of the full text or essential information. A random-effects meta-analysis was used to measure overall prevalence estimates of unemployment and early retirement. We used meta-regression and subgroup analysis to evaluate potential moderators of prevalence estimates and the leave-one-out method for sensitivity analyses.

Results

Our research identified 153 studies across 29 countries encompassing 188436 subjects with MS. The pooled overall effect size for unemployment and early retirement was 35.6% (95% CI 32.8–38.4; I2 = 99.31) and 17.2% (95% CI 14.6–20.2; I2 = 99.13), respectively. The prevalence of unemployment varied according to the year of publication (p < 0.001) and there was a statistically significant decrease in the prevalence of unemployment over time (p = 0.042). Regarding early retirement, only seven (31.8%) estimates obtained from studies that were published before 2010 were below the overall effect size in comparison to 27 (60.0%) estimates extracted from data published between 2010 and 2021 (p = 0.039). There was a significant difference in prevalence according to countries (p < 0.001). Psychiatric illness was an important clinical feature responsible for patients leaving the workforce in regions with a high MS prevalence.

Conclusions

Unemployment and early retirement due to MS remain highly prevalent, despite a slight decline in the last decade. The prevalence of unemployment and early retirement varies globally.
OER Impact Assessment: A framework for higher education institutions and beyond. Approaches to assess the impact of Open Educational Resources
Authors: Ebner Martin , Orr Dominic , Schön Sandra
Published: July 2022

The purpose of this paper is to provide an overview of approaches to and insights for impact assessment on open educational resources (OER) in higher education and building on this to sketch a framework for university focussed OER impact assessment. The authors describe the literature on impact assessment in the OER context and the existing contributions to OER impact assessment in higher education. Findings of the analysis are that there are few contributions on the effects of OER in general or of specific OER initiatives. Four contributions are presented in more detail. From these examples and the literature analysis, derivations, and challenges for OER impact assessment are drawn, such as the large diversity in OER purposes and the invisibility of the re-usage of OER. The contribution sketches a framework model for describing OER-relevant results, outcomes, and impact, and more specifically demonstrates how this can be done for exemplary OER-related objectives. This contribution is thus of relevance to funding bodies and institutions working in the context of higher education that wish to systematically evaluate and monitor statements about the effectiveness of OER activities according to the UNESCO (2019) OER recommendation.
Continuity properties and Bargmann mappings of quasi-Banach Orlicz modulation spaces
Authors: Toft Joachim , Üster Rüya , Nabizadeh Morsalfard Elmira , Öztop Serap
Published: July 2022

We deduce continuity, compactness and invariance properties for
quasi-Banach Orlicz modulation spaces on

ℝ
d

{\mathbb{R}^{d}}

. We characterize such spaces
in terms of Gabor expansions and by their images under the Bargmann transform.
Construction of an IoT customer operation analysis system based on big data analysis and human-centered artificial intelligence for web 4.0
Authors: Liu Xinxin , Liu Baojing , Han Chenye , Li Wei
Published: July 2022

Internet of thing (IoT) building sensors can capture several types of building operations, performances, and conditions and send them to a central dashboard to analyze data to support decision-making. Traditionally, laptops and cell phones are the majority of Internet-connected devices. IoT tracking allows customers to close the distance between devices and enterprises by collecting and analyzing various IoT data through connected devices, customers, and applications on the network. There is a lack of requirements for IoT edge applications security and approval. There are no best practices regarding operations focused on IoT incidents. IoT elements are not covered by audit and logging requirements. In this article, a big data analytics-based customer operation (BDA-CO) system analyzes the operation. With the exponential rise in data usage, the explosive development in the IoT devices reflects the ideal overlap of big data growth with IoT. Big data analytics continuously evolving network raises trivial questions about the performance, distribution of data, analysis, and protection of data collection. IoT modifies almost all the construction industry characteristics. Human-centered artificial intelligence is described as systems that always improve because of human input while also delivering an effective experience between the human and the robotic. The IoT is the key factor that ensures greater building performance. It was the first evolution of technology in a long time to turn genuine inventions into an industry that depended heavily on paper and manual processes. The benefits of the IoT in construction are now quite obviously much heavier than those of current manual processes. As a result, more construction companies explore and incorporate IoT strategies to address their productivity challenges, increasing efficiencies and profits. The simulation analysis shows that the proposed BDA-CO model enhances the trust score of 98.5%, accuracy detection ratio of 93.4%, probability ratio of 97.6%, and security ratio of 98.7% and reduces the false negative ratio of 21.3%, response time of 10.5%, delay rate of 19.9%, and packet loss ratio of 15.4% when compared to other existing techniques.
How Self-Concept, Competence, and Their Fit or Misfit Predict Educational Achievement, Well-Being, and Social Relationships in the School Context
Authors: Schneider Sarah , Lösch Thomas , Schneider Daniel , Schütz Astrid
Published: July 2022

During adolescence, what is more important for educational achievement, well-being, and the formation of positive social relationships: being competent, having positive thoughts about oneself, or a complex relationship between the two? There has been a long-standing debate in psychology on the effects of accurate and biased self-perceptions, and sophisticated ways of modeling the effects of self-perception, competence, and their interplay have recently been suggested. But recent research has focused on adults and has not taken reference effects into account. The present preregistered study used a large German sample of students (N = 6,086 students in 559 classes) in Grade 5 (mean age = 10.55 years, SD = 0.64) with data from the National Educational Panel Study (NEPS). We tested the effects of academic self-concept and competence in math and reading on outcomes pertaining to achievement, well-being, and social relationships up to 4 years later and identified the best fitting hypotheses through a model fit comparison. In contrast to previous studies, we took the frame of reference for students’ self-concept into account by controlling for class-level effects of self-concept and competence in a multilevel analysis. Results showed that educational achievement was best explained by the complex interplay of self-concept and competence, where competence was the stronger predictor. By contrast, self-concept was a stronger predictor of well-being than competence was. For social relationships, results were less clear and differed by the specific outcome variables that were used. Overall, in the school context, self-concept and competence per se seem to be more predictive of future outcomes than their fit or misfit.
Mapping the Territorial Distribution of Voter Turnout in Czech Local Elections (1994–2018)
Authors: Maškarinec Pavel
Published: July 2022

This article analyzes voter turnout in the Czech Republic on a very detailed spatial structure and an extended yearly time series (1994–2018). Its main goal is to examine the spatial dimension of the disparities in voter turnout in local elections at the level of all (more than 6,000) Czech municipalities. To achieve this goal, global and local spatial autocorrelation methods are used. Municipality-level cartographic presentations then provide spatial evidence of highly stable patterns of electoral participation in Czech municipalities. In the long term, there is no substantial inter-electoral change of the clustering of voter turnout in the different municipalities, except for an overall decline of the homogeneity of the clusters with low or high electoral turnout. In short, the article provides an understanding of electoral turnout in Czech local elections that other approaches have not achieved.
Improving Honest Attitude and Learning Outcomes Human Excretion System using Discovery Learning
Authors: Nursaadah Siti , HP Mulyadi
Published: July 2022

The purpose of this research is to determine the improvement of honest attitude and learning result of human excretion system material using the discovery learning model in class VIII H SMP 5 Semarang semester 2 of 2018/2019. This research is a classroom action research. These research subjects are all students of class VIII H SMP 5 Semarang consisting of 32 people. This research was conducted with pre-cycle, cycle I, and cycle II stages. Data collection techniques are carried out by means of documentation techniques in the initial conditions, observation techniques, and test techniques in the first cycle and second cycle. Data analysis techniques by comparing the variables of honest attitude and learning outcomes in the initial conditions with conditions in the first cycle and second cycle. The results showed that there was an increase in students' honesty in the pre-cycle stage (73.68%), the first cycle (82.81%), and the second cycle (88.28%). There was an increase in learning outcomes before the action (pre-cycle) (59%), cycle I (79.86%), and cycle II (87.06%). Improving students' honesty and learning outcomes becomes a consideration for teachers to use discovery learning models and becomes information material for schools to prepare media or learning materials for discovery learning models.
ANALISIS FOREHAND OVERHEAD DROPSHOT ATLET U-15 PUTRA PB. SATRIA KABUPATEN TEGAL
Authors: Erawati Revi , Suratman Suratman
Published: July 2022

Hasil observasi pada 5 atlet Under-15 Persatuan Bulutangkis Satria Tegal saat bermain terjadi 108pukulan forehand overhead lob dengan hasil 57 berhasil dan 51 mengalami eror. Masalah penelitian ini adalah bagaimana kemampuan pukulan forehand overhead drop shot para Atlet Under-15 PutraPersatuan Bulutangkis Satria Tegal? Penelitian ini untuk menganalisis kemampuan pukulan forehandoverhead drop shot para Atlet tersebut. Penelitian dilakukan terhadap 12 sampel atlet Under-15Persatuan Bulutangkis Satria menggunakan Accidental Sampling. Data diperoleh dengan menganalisisrekaman pukulan forehand overhead drop shot sebanyak 20 kali pukulan dari setiap sampelmenggunakan software kinovea pada bagian pegangan raket, sikap berdiri, gerak kaki ke belakang,ayunan lengan, saat impact dan Gerakan Kembali ketengah. Selanjutya data dianalisis menggunakanfault tree analysis, dilanjutkan membuat prosentase kemampuan forehand overhead dropshot. Hasilpenelitian menunjukkan bahwa pukulan forehand overhead drop shot para atlet berada pada kategoribaik. Kesalahan yang masih terjadi antara lain shuttlecock jatuh jauh dari net, arah penerbanganshuttlecock terlalu tinggi, dan shuttlecock tidak mengarah ke sasaran.
Low and high postpubertal ethanol use: damage on adulthood reproduction and offspring
Authors: Fioravante Vanessa Caroline , Godoi Alana Rezende , Camargo Victória Mokarzel de Barros , Pinheiro Patricia Fernanda Felipe , Martinez Marcelo , Padovani Carlos Roberto , Martinez Francisco Eduardo
Published: July 2022

Graphical abstract

The relationship between adolescent ethanol uses and its impacts throughout life are not conclusive. Thus, we evaluated if the low and high consumption of ethanol at postpuberty interferes with the reproduction and ethanol-naive offspring and if the effects are dose-related. Female and male rats were divided into three groups: low drinker (L), high drinker (H) and control (C). The L and H groups were exposed to ethanol up to 10 % from 65 to 80 days with withdrawal after this period. The ethanol consumed by low drinkers was 1.41 ± 0.21 g/kg/day and by high drinkers 4.59 ± 0.45 g/kg/day. The study was conducted in two phases. The first phase verified the reproductive capacity in adulthood on generations (litter size and sex ratio). Data were collected over 10 years. The second phase analyzed the parent reproductive parameters (body weight, reproductive organ weight, sperm parameters and estrous cycle) and the pup development. We observed a reduced litter size in both drinker groups. Gestational body weight gain and feed consumption were lower in L and H. We observed an alteration in reproductive organs weight in both sexes of H. Females presented a longer estrous cycle duration. Males presented an increase in abnormal sperm, a decrease in sperm count and accelerated transit time. The ethanol-naive offspring development was also impaired. We conclude that low and high postpubertal alcohol use impairs long-term reproductive parameters, even after alcohol withdrawal. There is also impaired ethanol-naive offspring. Besides, the effects are dose-related.

Lay summary

The effects of alcohol use have been reported in several studies. However, better knowledge about early alcohol use and its impact on reproduction in adulthood, after abstinence and on ethanol-naive offspring could help improve preventive measures and mechanisms of action. One of the methods used was retrospective analysis which allows to evaluate the effects of postpubertal ethanol use on the reproductive capacity of rats over generations. Despite our limitations, we verified that the post-adolescent period acts as a susceptibility window, and lifestyle at this age modulates the long-term reproductive parameters. The early ethanol use impairs reproduction function since sperm parameters and the estrous cycle have been altered. The dose of alcohol also contributes to damage on the drinkers’ reproduction and on the physical development of ethanol-naive offspring. Future studies are necessary to identify the mechanism involved in long-term alcohol use effects, even in withdrawal, as well as ethanol-naive offspring outcomes.
ENDOCELL-Seud: a Delphi protocol to harmonise methods in endometrial cell culturing
Authors: Romano Andrea , Guo Sun-Wei , Brosens Jan , Fazlebas Asgerally , Gargett Caroline E , Giselbrecht Stefan , Gotte Martin , Griffith Linda , Taylor Hugh S , Taylor Robert N , Vankelecom Hugo , Chapron Charles , Chang Xiao-Hong , Khan Khaleque N , Vigano’ Paola
Published: July 2022

In vitro

culturing of endometrial cells obtained from the uterine mucosa or ectopic sites is used to study molecular and cellular signalling relevant to physiologic and pathologic reproductive conditions. However, the lack of consensus on standard operating procedures for deriving, characterising and maintaining primary cells in two- or three-dimensional cultures from eutopic or ectopic endometrium may be hindering progress in this area of research. Guidance for unbiased in vitro research methodologies in the field of reproductive science remains essential to increase confidence in the reliability of in vitro models. We present herein the protocol for a Delphi process to develop a consensus on in vitro methodologies using endometrial cells (ENDOCELL-Seud Project). A steering committee composed of leading scientists will select critical methodologies, topics and items that need to be harmonised and that will be included in a survey. An enlarged panel of experts (ENDOCELL-Seud Working Group) will be invited to participate in the survey and provide their ratings to the items to be harmonised. According to Delphi, an iterative investigation method will be adopted. Recommended measures will be finalised by the steering committee. The study received full ethical approval from the Ethical Committee of the Maastricht University (ref. FHML-REC/2021/103). The study findings will be available in both peer-reviewed articles and will also be disseminated to appropriate audiences at relevant conferences.

Lay summary

Patient-derived cells cultured in the lab are simple and cost-effective methods used to study biological and dysfunctional or disease processes. These tools are frequently used in the field of reproductive medicine. However, the lack of clear recommendations and standardised methodology to guide the laboratory work of researchers can produce results that are not always reproducible and sometimes are incorrect. To remedy this situation, we define here a method to ascertain if researchers who routinely culture cells in the lab agree or disagree on the optimal laboratory techniques. This method will be used to make recommendations for future researchers working in the field of reproductive biology to reproducibly culture endometrial cells in the laboratory.
Cholesterol supports bovine granulosa cell inflammatory responses to lipopolysaccharide
Authors: Horlock Anthony D , Ormsby Thomas J R , Clift Martin J D , Santos José E P , Bromfield John J , Sheldon I Martin
Published: July 2022

In brief

Bovine granulosa cells need to be cultured with serum to generate inflammation in response to bacterial lipopolysaccharide. This study shows that it is cholesterol that facilitates this lipopolysaccharide-stimulated cytokine secretion.

During bacterial infections of the bovine uterus or mammary gland, ovarian granulosa cells mount inflammatory responses to lipopolysaccharide (LPS). In vitro, LPS stimulates granulosa cell secretion of the cytokines IL-1α and IL-1β and the chemokine IL-8. These LPS-stimulated inflammatory responses depend on culturing granulosa cells with serum, but the mechanism is unclear. Here, we tested the hypothesis that cholesterol supports inflammatory responses to LPS in bovine granulosa cells. We used granulosa cells isolated from 4 to 8 mm and >8.5 mm diameter ovarian follicles and manipulated the availability of cholesterol. We found that serum or follicular fluid containing cholesterol increased LPS-stimulated secretion of IL-1α and IL-1β from granulosa cells. Conversely, depleting cholesterol using methyl-β-cyclodextrin diminished LPS-stimulated secretion of IL-1α, IL-1β and IL-8 from granulosa cells cultured in serum. Follicular fluid contained more high-density lipoprotein cholesterol than low-density lipoprotein cholesterol, and granulosa cells expressed the receptor for high-density lipoprotein, scavenger receptor class B member 1 (SCARB1). Furthermore, culturing granulosa cells with high-density lipoprotein cholesterol, but not low-density lipoprotein or very low-density lipoprotein cholesterol, increased LPS-stimulated inflammation in granulosa cells. Cholesterol biosynthesis also played a role in granulosa cell inflammation because RNAi of mevalonate pathway enzymes inhibited LPS-stimulated inflammation. Finally, treatment with follicle-stimulating hormone, but not luteinising hormone, increased LPS-stimulated granulosa cell inflammation, and follicle-stimulating hormone increased SCARB1 protein. However, changes in inflammation were not associated with changes in oestradiol or progesterone secretion. Taken together, these findings imply that cholesterol supports inflammatory responses to LPS in granulosa cells.
Rapidly Progressive Right Atrial Angiosarcoma with Atrial Perforation
Authors: Zheng Dechang , Tang Han , Yang Bao fu , Wu Jian
Published: July 2022

Cardiac angiosarcomas are highly aggressive, extremely rare malignancies with a poor prognosis. We report the case of a 39-year-old woman presenting with a right atrial angiosarcoma with perforation of the right atrium. There is almost always a diagnostic lag for cardiac angiosarcoma, leading to a poor prognosis. Cardiovascular sarcoma is one of the most invasive malignant tumors. Radical resection surgery as the core of comprehensive treatment presently is the best treatment plan.
A Diuretic Response is Associated with the Early Prognosis of Patients Undergoing Repeat Tricuspid Valve Surgery Due to Severe Tricuspid Regurgitation After Left-Sided Valvular Surgery
Authors: Liu Ruofan , Xu Jianping , Li Yuntao , Li Bin , Liu Shen , Pan Guangyu , Tong Minghui
Published: July 2022

Objective: To analyze the factors affecting the early prognosis of patients undergoing repeat tricuspid valve surgery due to severe tricuspid regurgitation after left-sided valvular surgery.
Method: We retrospectively analyzed 76 patients undergoing repeat tricuspid valve surgery due to severe tricuspid regurgitation after left-sided valvular surgery at Peking University International Hospital between October 2017 and February 2021. Patients were divided into two groups, according to preoperative weight control and whether the adjusted diuretic dose exceeded 40 mg of furosemide (or the equivalent dose). The factors affecting the early prognosis were analyzed through postoperative follow up.
Results: Thirty-five male patients (46.1%), aged 57±13 years, were enrolled in the study. For the patients who received a preoperative same dose of furosemide ≥40 mg/day and a same dose of furosemide <40 mg/day, the baseline data basically were the same. There were 76 patients (100%) who were followed up. Endpoint events during the follow up were as follows: Six patients (7.9%) died, two patients (2.6%) were admitted to the hospital or transferred to the intensive care unit due to cardiac insufficiency, and other conditions such as severe tricuspid regurgitation on repeat ultrasound, bilateral lower extremity edema, and inability to reduce or stop diuretics were found in five cases (6.6%). Compared with the group with the same dose of furosemide <40 mg/day group, the ≥40 mg/day group had a higher incidence of endpoints (12, 27.3% vs. 1, 3.1%, P = 0.006).
Conclusion: In patients undergoing repeat tricuspid valve surgery due to severe tricuspid regurgitation after left-sided valvular surgery, a diuretic response was associated with surgical prognosis. Compared with the low-dose furosemide group, the high-dose group (≥40 mg/) had a significantly increased incidence of early events.
ПОЛІТИЧНЕ ПЕРЕЖИВАННЯ ІЛЮСТРАЦІЇ ВІЙНИ: СИНТАГМАТИЧНИЙ АНАЛІЗ ВІЗУАЛЬНИХ СИМВОЛІВ
Authors: Astapova-Vyazmina Olena Igorivna
Published: July 2022

Метою дослідження є активізація синтаксичної складової знакового процесу в площині візуальної символіки війни. Синтагматичний аналіз візуалізації війни дозволяє артикулювати приховані структури, що є основою домінуючого значення відповідних текстів, зробити їх видимими та зрозумілими. Війна, формуючи контекст семіотичної істинності, існує в площині просторово-часових відносин, що дозволяє чітко окреслювати знакову систему, яку вона формує . Війна, будучи одночасно і епістемічною ситуацією, і епістемічною системою, формує суб’єктну істинність, створюючи нову смислову домінанту нової картини світу. Синтагматичний ланцюжок розкриватиметься через емоційний настрій читача/глядача, висвітлення відповідної моральної позиції щодо візуального тексту, висловлення політичного переживання, що загострюється питанням ідентифікації та свободи дії.
KASIMIERZ TWARDOWSKI’S ANALYSIS OF THINKING AND RATIONALISM
Authors: Karivets Ihor Volodymyrovych
Published: July 2022

In this article, the author considers Kazimierz Twardowski’s conception of thinking and his rationalism. The author argues that rationalism of Kazimierz Twardowski is atypical, because it is a combination of inductive and deductive methods of cognition and acquisition of knowledge. Beside this, his rationalism has constructive tendencies. Kazimierz Twardowski was an analytic philosopher, who payed big attention to the process of thinking and analyzed the forms of thinking, i.e. notions and judgments. Polish philosopher and the founder of Lviv-Warsaw School was convinced that a specialist in philosophy in order to do good philosophy must understand the specificity of thinking process, its forms and how to construct them. Therefore psychology of thinking is very important for philosopher, because it can help to understand the nature of thinking. Beside psychology of thinking, logic is also very important tool for doing philosophy. Logic is very helpful for philosopher, who takes care about the strictness and clearness of thinking, about formation of strict and clear judgments. Logical analysis of notions and judgments provides strong protection against linguistic mistakes which are connected with linguistic inaccuracy and obscurity.
Г. МАРСЕЛЬ: СІМ’Я ЯК ОБ’ЄКТ ФІЛОСОФСЬКОЇ РЕФЛЕКСІЇ
Authors: Osetrova Oksana
Published: July 2022

Кризові явища, які наразі охопили як світ загалом, так і Україну, зокрема, загостривши стан аномії – економічної, шлюбної, сімейної, позначилися не тільки на державах, окремих особах, але й на сім’ї як малій соціальній групі. Так, COVID-19 і спричинений ним карантин послужили джерелом відчуження та зростання непорозумінь всередині сім’ї, а повномасштабна війна, розв’язана РФ проти України, як джерело хаосу й смерті явила собою одну з важливих причин деструктивних процесів, які актуалізували проблематику сім’ї та сімейних цінностей загалом і прийомної сім’ї, зокрема, оскільки збільшилася кількість дітей, які потребують переміщення, та загострилася проблема соціального сирітства. У даному контексті особливий науково-дослідницький інтерес викликають фамілістичні погляди французького мислителя Г. Марселя, сформовані у часи Другої світової війни. У зв’язку з цим мета даного дослідження полягає у з’ясуванні ключових світоглядно-ціннісних координат Г. Марселя щодо сутності та функцій сім’ї, а також у співвіднесенні його філософської позиції з реаліями сучасної України. Під час дослідження з’ясовано, що світоглядно-ціннісна позиція Г. Марселя з фамілістичних питань наразі є актуальна, оскільки мислитель акцентує увагу на осмисленому підході до створення сім’ї, здатної усвідомлено зреалізувати місію творця, не тільки відтворивши потомство, але й усвідомлено вклавши в нього (у дітей) екзистенціальну іскру. Заслуговують на увагу й виокремлені філософом ризики усиновлення, яке, на його думку, не має носити у суспільстві розповсюджений характер. Однак у сучасних умовах існування українського народу ця настанова втратила свою актуальність, оскільки немає «чужих» дітей, а потреба в усиновленні наразі зумовлена ситуацією війни, наслідки якої позначаються на представниках усіх вікових категоріях, безпосередньо впливаючи на свідомість і підсвідоме дітей.
СУТНІСТЬ ГУМАНІЗМУ КРІЗЬ ПРИЗМУ УЯВЛЕНЬ ПРО ПРИРОДУ ЛЮДИНИ
Authors: Khodanych Yurii Mykhailovych
Published: July 2022

Стаття присвячена аналізу кількох філософських підходів на предмет природи людини і сутності гуманізму (Немезія Емеського, Піко делла Мірандоли, Л.Фейєрбаха, Ж.-П.Сартра і М.Гайдеггера) як дотичних явищ. Автор формулює об’єднуючі мотиви означених підходів мислителів. У результаті надається характеристика гуманістичному світогляду, притаманному сучасній західній цивілізації, виходячи зі значимості проаналізованих концепцій.
ПРОБЛЕМА МЕДІАГРАМОТНОСТІ ПРИ СПОЖИВАННІ ІНФОРМАЦІЇ В УМОВАХ ВІЙНИ: СОЦІОЛОГІЧНИЙ АСПЕКТ
Authors: Stadnik Oksana , Vanyushina Olena , Polovaia Nataliia
Published: July 2022

Метою статті виступає теоретичний аналіз проблематики медіаграмотності суспільства при споживанні інформації в умовах війни. Методологічну основу статті становлять загальнонаукові методи пізнання соціальних явищ і процесів. У ході дослідження використано такі методи: логіко-історичного, структурно-функціонального аналізу – для виявлення етапів еволюційного розвитку наукових підходів до трактування концепту «медіаграмотність» в соціологічний науці та сучасного його інтерпретування; аналізу та синтезу – для уточнення поняття «медіаосвіта»; узагальнення – для визначення тенденцій та завдань медіаграмотності у сучасного суспільства. В статті проаналізовано появу та розвиток основних інформаційних революцій в світі та їх причини. Охарактеризовано поняття «медіаграмотність» та «медіаосвіта» їх стан та значення у сучасному світі. Теоретичне значення результатів: можуть бути впровадженні при розробці навчальних курсів з медіаграмотності.
Makedonien, südlicher Teil. Mit Beiträgen von Andreas Pülz und unter Mitwirkung von Mihailo St. Popović. Mit 198 Abbildungen auf Tafeln, einer Grundkarte und drei Sonderkarten
Authors: Soustal Peter
Published: July 2022

Thema des 11. Bandes der Reihe „Tabula Imperii Byzantini (TIB)“ ist die historisch-geographische Darstellung des südlichen Teils der historischen Landschaft Makedonien im Norden Griechenlands für die Zeit vom 4. bis zum 15. Jahrhundert. Das Gebiet grenzt an die Regionen Thessalien, Epirus und Thrakien, die in den Bänden TIB 1, TIB 3 und TIB 6 erforscht und veröffentlicht wurden. Der nördlich anschließende Teil Makedoniens wird von Mihailo Popović für den 16. Band der TIB („Makedonien, nördlicher Teil“) verfasst und wird ausführliche einleitende Kapitel zu der gesamten historischen Landschaft Makedonien (also TIB 11 und 16) enthalten. Seit der Antike ist Thessalonikē politisches, militärisches, wirtschaftliches und besonders in den späteren Jahrhunderten auch kulturelles und religiöses Zentrum ersten Ranges. Die Athōs-Halbinsel entwickelte sich im 10. Jahrhundert zu einem Klosterberg mit spiritueller und wirtschaftlicher Ausstrahlung weit über seine Grenzen hinaus. Die Daten aus den schriftlichen Quellen (darunter sind zahlreiche Urkunden von Klöstern über Landbesitz und frühosmanische Steuerurkunden), die sakralen und profanen Baudenkmäler sowie die Ergebnisse archäologischer Forschungen und Bereisungen werden nach einer kurzen Einführung und einem geographischen Überblick in Lemmata zu Siedlungen, Klöstern, Gewässern und Landschaftsnamen dargelegt und durch zwei Register, ein geographisches und ein Sachregister, erschlossen. Drei Sonderkarten (1:400.000) ergänzen die Karte des gesamten Bearbeitungsgebietes (1:800.000). Der Abbildungsteil am Ende des 2. Teilbandes von TIB 11 dokumentiert eine Auswahl für die Region typischer Denkmäler und Landschaften.
Formation energetics/dynamics of icosahedral clusters in supercooled metallic liquids in the dynamic equilibrium regime: Gibbs free energy, entropy, enthalpy, and connection to coordination shells
Authors: Chang Tzu-Yi , Wang Zhengming , Xu Donghua
Published: July 2022

Icosahedral (ICO) clusters are known to exist in many supercooled metallic liquids and believed to play an important role in stabilizing the liquid before it transitions into a glassy, crystalline or quasicrystalline solid. However, a detailed understanding of their formation energetics/dynamics is currently lacking and a set of key questions regarding these clusters remains to be answered. Here, we report our study on the formation energetics/dynamics of ICO clusters in liquid Cu64Zr36 and Ta by combining MD simulations with statistical and theoretical analysis. We present the formation Gibbs free energy, entropy, enthalpy of ICO clusters in the two liquids in the dynamic equilibrium regime (T > 0.75 Tm), determine the size of the spatial domain (number of coordination shells) surrounding the clusters from which the formation enthalpy is originated, and discuss the results in connection with liquid composition, degree of randomness, potential energy landscape, and glass transition.

Graphical abstract
Digital literacy among Students and Teachers
Authors: Khan Saba Nasreen
Published: July 2022

With the advent of the internet, many sectors went into Digi-mode. During this time, a lot of work began to be done online and the convenience led it to spread. The pandemic brought about a faster spread of digital usage among people. Commercial sectors, government units, educational
sectors, sales and retail, food and groceries; all these units and many more embraced the online platform. Like all other sectors, the educational sector also became dependent on digital classes and e-learning. With this, it became inevitable for the students and the teachers to educate themselves
digitally. This scenario brought a need for not only students and teachers to be educated digitally but also for the parents as well, since they were now more involved in their child's education than before. The parents of the students were now responsible for making sure that the child had
completed the work given, for making sure that they are available online physically and mentally during the class. It has been a huge change for everyone to be moving into a digital phase and while many have gladly embraced it and are finding it very convenient, there are others who are facing
technical problems like inconsistent electricity supply, lack of necessary devices, low speed bandwidth and many more. In this paper, I am going to talk about digital literacy among students and teachers what are the challenges that they have faced and how they brought about solutions to the
challenges and what more can be done to enhance digital literacy among teachers and students.
“The True and Only Bones of Columbus”: Relics, Archives, and Reversed Scenarios of Discovery
Authors: Serrata Médar
Published: July 2022

This essay examines the ceremonies surrounding the 1877 alleged finding of Christopher Columbus's remains in the cathedral of Santo Domingo. The act of exhuming a body believed to be in Spain's possession posed a challenge for the former colonial power, which was in the process of turning Columbus into a national symbol. The Spanish government forcefully denied the legitimacy of the Dominican claim, calling it a “spectacle” contrived by the nation's religious and civil authorities. Building on Diana Taylor's theoretical framework, the essay looks at the 1877 ceremonies as social performances that facilitated the transmission of deeply rooted cultural memories. Whereas the procession of the remains from the cathedral to the church repeated the ritualized gestures prescribed for the discovery and transfer of relics, the performance enacted in the cathedral upended a different “scenario of discovery”—the one enacted by Spanish conquerors when they took possession of a new territory.
Pound's Four Pages: “Literary Camouflage” and Postwar Anonymous Propaganda
Authors: Hentea Marius
Published: July 2022

This essay examines Ezra Pound's behind-the-scenes control of the little review Four Pages, which ran for fifteen issues from 1948 to 1951. After his return to the United States in 1945 to face charges of treason, Pound was declared mentally incompetent and institutionalized in a mental hospital in the nation's capital. With his publishers attempting to rehabilitate Pound's public standing by spotlighting his purely “literary” efforts, Pound had to resort to anonymous publication to continue to have a say on contemporary matters. This essay shows how Pound essentially created and edited a little review to have a venue that pushed his social and political ideas at a time when doing so openly was problematic for legal and political reasons. The use of anonymity as a writer and editor was part of the wider “literary camouflage” that Four Pages engaged in to advance Pound's wider cultural and political agenda.