bluuebunny/crossref_metadata_2025 huggingface dataset:
Multicomponent Shale Oil Flow in Real Kerogen Structures via Molecular Dynamic Simulation
Authors: Liu Jie , Zhao Yi , Yang Yongfei , Mei Qingyan , Yang Shan , Wang Chenchen
Published: July 2020

As an unconventional energy source, the development of shale oil plays a positive role in global energy, while shale oil is widespread in organic nanopores. Kerogen is the main organic matter component in shale and affects the flow behaviour in nanoscale-confined spaces. In this work, a molecular dynamic simulation was conducted to study the transport behaviour of shale oil within kerogen nanoslits. The segment fitting method was used to characterise the velocity and flow rate. The heterogeneous density distributions of shale oil and its different components were assessed, and the effects of different driving forces and temperatures on its flow behaviours were examined. Due to the scattering effect of the kerogen wall on high-speed fluid, the heavy components (asphaltene) increased in bulk phase regions, and the light components, such as methane, were concentrated in boundary layers. As the driving force increased, the velocity profile demonstrated plug flow in the bulk regions and a half-parabolic distribution in the boundary layers. Increasing the driving force facilitated the desorption of asphaltene on kerogen walls, but increasing the temperature had a negative impact on the flow velocity.
Net Present Value Analysis of a Hybrid Gas Engine-Energy Storage System in the Balancing Mechanism
Authors: Anvari-Azar Farhad , Strickland Dani , Filkin Neil , Townshend Harry
Published: July 2020

There is the potential for hybridised gas engine-energy storage systems to participate in the Balancing Mechanism (BM) by offering a product that marries the advantages of both units. The higher price offerings are currently dominated by pumped storage (PS) assets. Given their high-flexibility, PS plants mostly offer at higher prices, but respond quicker and can run for a smaller minimum run time than a gas engine on its own. The operation of the hybrid system must match the operation of the pumped storage plants, to be able to claim a space in this part of the BM market including meeting a minimum run time and minimum start time. The business case is dependent on battery costs which in turn depend on size and operational strategy. This paper uses a case study approach to estimate Net Present Value of a hybrid system. The paper uses a mixture of publicly available data and industrially provided data within its analysis. The paper concludes that battery cost and lifespan are still issues and that battery-engine hybrids are not economic at present. There is indication in the modelling that under very favorable conditions such as low compound interest rates, an acceptance of offers above 7 times/day and low gas price, it is possible to see a return on investment of a lithium ion-based battery-gas engine hybrid.
Closed-Loop PI Control of an Organic Rankine Cycle for Engine Exhaust Heat Recovery
Authors: Zhang Wen , Wang Enhua , Meng Fanxiao , Zhang Fujun , Zhao Changlu
Published: July 2020

The internal combustion engine (ICE) as a main power source for transportation needs to improve its efficiency and reduce emissions. The Organic Rankine Cycle (ORC) is a promising technique for exhaust heat recovery. However, vehicle engines normally operate under transient conditions with both the engine speed and torque varying in a large range, which creates obstacles to the application of ORC in vehicles. It is important to investigate the dynamic performance of an ORC when matching with an ICE. In this study, the dynamic performance of an ICE-ORC combined system is investigated based on a heavy-duty diesel engine and a 5 kW ORC with a single-screw expander. First, dynamic simulation models of the ICE and the ORC are built in the software GT-Power. Then, the working parameters of the ORC system are optimized over the entire operation scope of the ICE. A closed-loop proportional-integral (PI) control together with a feedforward control is designed to regulate the operation of the ORC during the transient driving conditions. The response time and overshoot of the PI control are estimated and compared with that of the feedforward control alone. The results based on the World Harmonized Transient Cycle (WHTC) indicate that the designed closed-loop PI control has a shorter response time and a better trace capacity during the dynamic processes. The average output power and thermal efficiency during the WHTC cycle are improved by 3.23% and 2.77%, respectively. Compared with the feedforward control alone, the designed PI control is more suitable for practical applications.
Determination of the Soiling Impact on Photovoltaic Modules at the Coastal Area of the Atacama Desert
Authors: Olivares Douglas , Ferrada Pablo , Bijman Jonathan , Rodríguez Sebastián , Trigo-González Mauricio , Marzo Aitor , Rabanal-Arabach Jorge , Alonso-Montesinos Joaquín , Batlles Francisco Javier , Fuentealba Edward
Published: July 2020

With an elevation of 1000 m above sea level, once the coastal mountain range is crossed, the Atacama Desert receives the highest levels of solar radiation in the world. Global horizontal irradiations over 2500 kWh/(m2 year) and a cloudiness index below 3% were determined. However, this index rises to 45% in the coastal area, where the influence of the Pacific Ocean exists with a large presence of marine aerosols. It is on the coastal area that residential photovoltaic (PV) applications are concentrated. This work presents a study of the soiling impact on PV modules at the coastline of Atacama Desert. The current–voltage characteristics of two multicrystalline PV modules exposed to outdoor conditions were compared, while one of them was cleaned daily. Asymptotic behavior was observed in the accumulated surface dust density, over 6 months. This behavior was explained by the fact that as the glass became soiled, the probability of glass-to-particle interaction decreased in favor of a more likely particle-to-particle interaction. The surface dust density was at most 0.17 mg·cm−2 per month. Dust on the module led to current losses in the range of 19% after four months, which in turn produced a reduction of 13.5%rel in efficiency.
Experimental Investigation of Vortex-Tube Streamwise-Vorticity Characteristics and Interaction Effects with a Finite-Aspect-Ratio Wing
Authors: Carlson Bailey , Ullah Al Habib , Estevadeordal Jordi
Published: July 2020

An experimental study is conducted to analyze a streamwise-oriented vortex and investigate the unsteady interaction with a finite-aspect-ratio wing. A pressurized vortex tube is used to generate streamwise vortices in a wind tunnel and the resulting flow behavior is analyzed. The vortex tube, operated at various pressures, yields flows that evolve downstream under several freestream wind tunnel speeds. Flow measurements are performed using two- and three- dimensional (2D and 3D) particle image velocimetry to observe vortices and their freestream interactions from which velocity and vorticity data are comparatively analyzed. Results indicate that vortex velocity greater than freestream flow velocity is a primary factor in maintaining vortex structures further downstream, while increased supply pressure and reduced freestream velocity also reduce vortex dissipation rate. The generated streamwise-oriented vortex is also impinged on a finite-aspect-ratio airfoil wing with a cross-section of standard NACA0012 airfoil. The wingtip-aligned vortex is shown to investigate the interaction of the streamwise vortex and the wingtip vortex region. The results indicate that the vorticity at the high vortex-tube pressure has a significant effect on the boundary layer of airfoil.
Improving the Functional Activities of Curcumin Using Milk Proteins as Nanocarriers
Authors: Taha Soad , El-Sherbiny Ibrahim , Enomoto Toshiki , Salem Aida , Nagai Emiko , Askar Ahmed , Abady Ghada , Abdel-Hamid Mahmoud
Published: July 2020

Curcumin is one of the most common spices worldwide. It has potential benefits, but its poor solubility and bioavailability have restricted its application. To overcome these problems, this study aimed to assess the efficacy of sodium caseinate (SC), α-lactalbumin (α-La), β-lactoglobulin (β-lg), whey protein concentrate (WPC) and whey protein isolate (WPI) as nanocarriers of curcumin. Furthermore, the antioxidant, anticancer and antimicrobial activities of the formed nanoparticles were examined. The physicochemical characteristics of the formed nanoparticles as well as the entrapment efficiency (%) and the in vitro behavior regarding the release of curcumin (%) were examined. The results showed that the formation of curcumin–milk protein nanoparticles enhanced both the entrapment efficiency and the in vitro behavior release of curcumin (%). Cur/β-lg nanoparticles had the highest antioxidant activity, while SC and WPC nanoparticles had the highest anticancer effect. The antimicrobial activity of the formed nanoparticles was much higher compared to curcumin and the native milk proteins.
Effect of L-cysteine, Boswellia serrata, and Whey Protein on the Antioxidant and Physicochemical Properties of Pork Patties
Authors: Yang Fengqi , Cho Won-Young , Seo Han Geuk , Jeon Byong-Tae , Kim Ji-Han , Kim Yuan H. Brad , Wang Yanmei , Lee Chi-Ho
Published: July 2020

This study investigated the effects of L-cysteine (C) combined with Boswellia serrata (B) and whey protein (W) on the antioxidant and physicochemical properties of pork patties. Proximate composition, water holding capacity (WHC), pH, texture profile analysis, sensory evaluation, thiobarbituric acid-reactive substances (TBARS), DPPH radical-scavenging activity, volatile basic nitrogen (VBN), and color stability were assessed. Patty VBN gradually increased throughout the storage period. However, VBN for the C treatment increased relatively slowly, indicating that cysteine can delay spoilage and extend the shelf life of patties. The protein content of the whey powder treatment group increased to a greater extent than that of the C and control (CON) groups. Pork patties supplemented with antioxidants showed significantly higher WHC and significantly lower cooking loss and hardness than the CON. Moreover, the addition of 2% whey, 1% B. serrata, and 0.25% cysteine (WBC) significantly enhanced the relative DPPH radical-scavenging activity and sensory characteristics of the patties. After 7-day storage, the MetMb and TBARS values of all treatments were significantly lower than those of the untreated. The results indicated that there was synergy among the cysteine, B. serrata, and whey protein. This finding is of great importance to the production of high-quality pork patties with enhanced shelf life.
Use of Calcium Amino Acid Chelate in the Production of Acid-Curd Goat Cheese
Authors: Pawlos Małgorzata , Znamirowska Agata , Zaguła Grzegorz , Buniowska Magdalena
Published: July 2020

Amino acid chelates are a new group of compounds approved for food enrichment, however there is no previous research using calcium amino acid chelate to enrich goat’s milk products. The purpose of this research was to evaluate the possibility of using calcium amino acid chelate to produce goat’s acid-curd cheese. In this study, four types of acid-curd cheeses from goat’s milk subjected to 85 °C/5 min treatment were produced: control cheeses—made from milk without calcium addition and cheeses from milk enriched with 30, 35 and 40 mg of Ca (in 100 g of milk) in the form of calcium amino acid chelate. Goat cheese with calcium amino acid chelate had a higher moisture content, and a lower fat content. More fat was separated with the whey. In cheeses made from the milk with calcium amino acid chelate there was no goaty taste. Enrichment with 35 mg of Ca in 100 g of goat milk increased the calcium content in cheese by 60.5% in comparison to the control sample. However, the enrichment of goat milk with 40 mg Ca (in 100 g of processed milk) increased the calcium content in cheese by only 63.29%.
Comparative Analysis of the Transcriptome and Distribution of Putative SNPs in Two Rainbow Trout (Oncorhynchus mykiss) Breeding Strains by Using Next-Generation Sequencing
Authors: de los Ríos-Pérez Lidia , Brunner Ronald Marco , Hadlich Frieder , Rebl Alexander , Kühn Carsten , Wittenburg Dörte , Goldammer Tom , Verleih Marieke
Published: July 2020

Selective breeding can significantly improve the establishment of sustainable and profitable aquaculture fish farming. For rainbow trout (Oncorhynchus mykiss), one of the main aquaculture coldwater species in Europe, a variety of selected hatchery strains are commercially available. In this study, we investigated the genetic variation between the local Born strain, selected for survival, and the commercially available Silver Steelhead strain, selected for growth. We sequenced the transcriptome of six tissues (gills, head kidney, heart, liver, spleen, and white muscle) from eight healthy individuals per strain, using RNA-seq technology to identify strain-specific gene-expression patterns and single nucleotide polymorphisms (SNPs). In total, 1760 annotated genes were differentially expressed across all tissues. Pathway analysis assigned them to different gene networks. We also identified a set of SNPs, which are heterozygous for one of the two breeding strains: 1229 of which represent polymorphisms over all tissues and individuals. Our data indicate a strong genetic differentiation between Born and Silver Steelhead trout, despite the relatively short time of evolutionary separation of the two breeding strains. The results most likely reflect their specifically adapted genotypes and might contribute to the understanding of differences regarding their robustness toward high stress and pathogenic challenge described in former studies.
AML with Myelodysplasia-Related Changes: Development, Challenges, and Treatment Advances
Authors: Koenig Kristin L. , Sahasrabudhe Kieran D. , Sigmund Audrey M. , Bhatnagar Bhavana
Published: July 2020

Acute myeloid leukemia (AML) with myelodysplasia-related changes (AML-MRC) is a distinct biologic subtype of AML that represents 25–34% of all AML diagnoses and associates with especially inferior outcomes compared to non-MRC AML. Typically, patients with AML-MRC experience low remission rates following intensive chemotherapy and a median overall survival of merely 9–12 months. In light of these discouraging outcomes, it has become evident that more effective therapies are needed for patients with AML-MRC. Liposomal daunorubicin–cytarabine (CPX-351) was approved in 2017 for adults with newly diagnosed AML-MRC and those with therapy-related AML (t-AML), and remains the only therapy specifically approved for this patient population. Other studies have also demonstrated the efficacy of the hypomethylating agent (HMA) azacitidine as upfront therapy for AML-MRC patients, which, to date, is the most common treatment employed for patients unable to tolerate the more intensive CPX-351. HMAs and venetoclax combinations have also been evaluated, but additional studies utilizing these agents in this specific subgroup are needed before conclusions regarding their role in the therapeutic armamentarium of AML-MRC patients can be reached. Currently, many studies are ongoing in attempts to further improve outcomes in this historically ill-fated patient group.
Genomic Dissection of a Wild Region in a Superior Solanum pennellii Introgression Sub-Line with High Ascorbic Acid Accumulation in Tomato Fruit
Authors: Aliberti Antonietta , Olivieri Fabrizio , Graci Salvatore , Rigano Maria Manuela , Barone Amalia , Ruggieri Valentino
Published: July 2020

The Solanum pennellii introgression lines (ILs) have been exploited to map quantitative trait loci (QTLs) and identify favorable alleles that could improve fruit quality traits in tomato varieties. Over the past few years, ILs exhibiting increased content of ascorbic acid in the fruit have been selected, among which the sub-line R182. The aims of this work were to identify the genes of the wild donor S. pennellii harbored by the sub-line and to detect genes controlling ascorbic acid accumulation by using genomics tools. A Genotyping-By-Sequencing (GBS) approach confirmed that no wild introgressions were present in the sub-line besides one region on chromosome 7. By using a dense single nucleotide polymorphism (SNP) map obtained by RNA sequencing (RNA-Seq), the wild region of the sub-line was finely identified; thus, defining 39 wild genes that replaced 33 genes of the ILs genetic background (cv. M82). The differentially expressed genes mapping in the region and the variants detected among the cultivated and the wild alleles evidenced the potential role of the novel genes present in the wild region. Interestingly, one upregulated gene, annotated as a major facilitator superfamily protein, showed a novel structure in R182, with respect to the parental lines. These genes will be further investigated using gene editing strategies.
Predicting Visual-Motor Performance in a Reactive Agility Task from Selected Demographic, Training, Anthropometric, and Functional Variables in Adolescents
Authors: Popowczak Marek , Domaradzki Jarosław , Rokita Andrzej , Zwierko Michał , Zwierko Teresa
Published: July 2020

Reactive agility (RA) directly refers to athletes’ visuomotor processing of the specific conditions for team sports. The aim of the study was to identify the factors among age, gender, sport discipline, time participation in a sports activity, reaction time, and visual field which could have an impact on visual-motor performance in RA tasks in young, competitive team sports players. The study included boys (n = 149) and girls (n = 157) aged 13–15 participating in basketball, volleyball and handball. Anthropometric measurements were carried out, and the Peripheral Perception (PP) test was used to evaluate the visual-motor performance under laboratory conditions. The Five-Time Shuttle Run to Gates test was used to determine the RA. A multiple regression analysis was performed to identify the relationships between the visual-motor performance in an RA task (dependent variable) and the remaining independent variables (continuous and categorical). The findings of the current study indicate that the main predictive factors of visual-motor performance in RA among young athletes are gender (ß = −0.46, p < 0.000) and age (ß = −0.30, p < 0.000). Moreover, peripheral perception positively affected the achievements in the RA task in boys (ß = −0.25, p = 0.020). The sport discipline does not differentiate the visual-motor performance in RA in team sports players in the puberty period.
The Differences across Future Teachers Regarding Attitudes on Social Responsibility for Sustainable Development
Authors: Estrada-Vidal Ligia Isabel , Olmos-Gómez María del Carmen , López-Cordero Rafael , Ruiz-Garzón Francisca
Published: July 2020

In the search for sustainable development, in which the ecological footprint is carefully considered by consumers and companies, teachers play an important role within a social and economic framework. This role relates to aspects of social responsibility. It should involve knowledge about education for responsible consumption in order to care for the environment both individually and socially. Considering this, the aim of this study is to find out whether there are differences in the level of awareness and the habits of future teachers of Early Childhood and Primary Education regarding sustainable social responsibility. A non-probabilistic sample of 30 Early Childhood Education degree students and 22 Primary Education degree students was used. Semi-structured interviews and an inductive process were conducted to examine the importance of Sustainable Development in society, the relevance of Social Responsibility for Sustainable Development (individual versus corporate), the attitudes and habits relative to Sustainable Development and the education on Sustainable Development in schools: knowledge, attitudes, and proposals. Students agree that they consume excessively. This is everyone’s individual responsibility (as regarded by all participants), although changes could be supported by institutions and companies (Early Childhood education students argue in favour of corporate responsibility). Knowledge deficits were identified in relation to production, distribution, and sale processes. They consider education to be the main factor for sustainability, while society is ranked as the least important, observing an evident disagreement in relation to environmental and economic factors (perception of collective responsibility; Early Childhood versus Primary Education students). Finally, they also outline teaching proposals (active and participatory) to foster education for sustainable development at schools.
The Role of Sports Practice in Young Adolescent Development of Moral Competence
Authors: Bronikowska Małgorzata , Korcz Agata , Bronikowski Michał
Published: July 2020

The study examined the moral competence levels in adolescents participating in individual/team sports compared with those not undertaking sports at all. In total, 827 students aged 15–17 years old (45.4% boys, 54.6% girls) from randomly selected secondary schools in the Wielkopolska region in Poland participated in the study. The moral competences were assessed using the Lind’s Moral Competence Test. The students also answered questions concerning their statues of involvement in sport (not involved; amateur; professional), years of involvement, and the type of sport they partook in (individual/team). The results highlight that the moral competence level in most of the examined adolescents (71.6% girls, 76.8% boys) was low. Those who presented a high moral competence level were 10.4% in girls, 8% in boys. There was no interaction between modes of involvement in sport and moral competence when comparing adolescents. The moral competence levels were not correlated with years of training in either mode of involvement or with type of sports. Therefore, we assume that, at this age, the type of sport and the level of engagement do not differentiate moral competence level and that there must be more factors contributing to this. This opens new directions for further research on the role of external factors stimulating the socio-moral growth of youth.
The Utility of Virtual Patient Simulations for Clinical Reasoning Education
Authors: Watari Takashi , Tokuda Yasuharu , Owada Meiko , Onigata Kazumichi
Published: July 2020

Virtual Patient Simulations (VPSs) have been cited as a novel learning strategy, but there is little evidence that VPSs yield improvements in clinical reasoning skills and medical knowledge. This study aimed to clarify the effectiveness of VPSs for improving clinical reasoning skills among medical students, and to compare improvements in knowledge or clinical reasoning skills relevant to specific clinical scenarios. We enrolled 210 fourth-year medical students in March 2017 and March 2018 to participate in a real-time pre-post experimental design conducted in a large lecture hall by using a clicker. A VPS program (®Body Interact, Portugal) was implemented for one two-hour class session using the same methodology during both years. A pre–post 20-item multiple-choice questionnaire (10 knowledge and 10 clinical reasoning items) was used to evaluate learning outcomes. A total of 169 students completed the program. Participants showed significant increases in average total post-test scores, both on knowledge items (pre-test: median = 5, mean = 4.78, 95% CI (4.55–5.01); post-test: median = 5, mean = 5.12, 95% CI (4.90–5.43); p-value = 0.003) and clinical reasoning items (pre-test: median = 5, mean = 5.3 95%, CI (4.98–5.58); post-test: median = 8, mean = 7.81, 95% CI (7.57–8.05); p-value < 0.001). Thus, VPS programs could help medical students improve their clinical decision-making skills without lecturer supervision.
Factors Associated with Students Meeting Components of Canada’s New 24-Hour Movement Guidelines over Time in the COMPASS Study
Authors: Buchan M. Claire , Carson Valerie , Faulkner Guy , Qian Wei , Leatherdale Scott T.
Published: July 2020

This study aimed to determine if secondary school students are meeting the new Canadian 24-Hour Movement Guidelines (24-MG), as well as each individual recommendation (physical activity; sleep; sedentary behavior) within the 24-MG, and which student-level characteristics predict meeting the 24-MG, both cross-sectionally and longitudinally. This study is the first to examine longitudinal changes in students meeting the 24-MG, as well as student-level characteristics that were predictive of favourable shifts in movement patterns. Cross-sectional data were obtained for 11,793 grade 9 students across Canada as part of the COMPASS study. Of this sample, 3713 students provided linked follow-up data from grade 9 to grade 12. The probability of meeting the guidelines was modeled using two-level logistic regression analyses, adjusting for student-level co-variates and school clustering. Only 1.28% (p < 0.0001) of the sample met the overall 24-MG. Among grade 9 students, 35.9% (p < 0.0001), 50.8% (p < 0.0001), and 6.4% (p < 0.0001) were meeting the individual recommendations for physical activity, sleep, and screen time, respectively. Of those students, less than half were still meeting them by grade 12. Community sport participation was the only predictor of all three individual recommendations within the 24-MG. Longitudinal analyses found that community sport participation and parental support and encouragement were significantly associated with Grade 12 students starting to meet the physical activity and screen time recommendations, respectively, after having not met them in grade 9. Findings can be used to inform policy and public health practice, as well as to inform future research examining causal relationships between the variables.
Review of Big Data Analytics, Artificial Intelligence and Nature-Inspired Computing Models towards Accurate Detection of COVID-19 Pandemic Cases and Contact Tracing
Authors: Agbehadji Israel Edem , Awuzie Bankole Osita , Ngowi Alfred Beati , Millham Richard C.
Published: July 2020

The emergence of the 2019 novel coronavirus (COVID-19) which was declared a pandemic has spread to 210 countries worldwide. It has had a significant impact on health systems and economic, educational and social facets of contemporary society. As the rate of transmission increases, various collaborative approaches among stakeholders to develop innovative means of screening, detecting and diagnosing COVID-19’s cases among human beings at a commensurate rate have evolved. Further, the utility of computing models associated with the fourth industrial revolution technologies in achieving the desired feat has been highlighted. However, there is a gap in terms of the accuracy of detection and prediction of COVID-19 cases and tracing contacts of infected persons. This paper presents a review of computing models that can be adopted to enhance the performance of detecting and predicting the COVID-19 pandemic cases. We focus on big data, artificial intelligence (AI) and nature-inspired computing (NIC) models that can be adopted in the current pandemic. The review suggested that artificial intelligence models have been used for the case detection of COVID-19. Similarly, big data platforms have also been applied for tracing contacts. However, the nature-inspired computing (NIC) models that have demonstrated good performance in feature selection of medical issues are yet to be explored for case detection and tracing of contacts in the current COVID-19 pandemic. This study holds salient implications for practitioners and researchers alike as it elucidates the potentials of NIC in the accurate detection of pandemic cases and optimized contact tracing.
Self-Reported Oral Health, Oral Hygiene and Associated Factors in Lithuanian Adult Population, 1994–2014
Authors: Raskiliene Asta , Kriaucioniene Vilma , Siudikiene Jolanta , Petkeviciene Janina
Published: July 2020

This study aimed to examine 20-year trends (1994–2014) in self-reported oral health and oral hygiene and to assess the associated factors in a Lithuanian population aged 20–64 years. Nationally representative cross-sectional data on 8612 men and 11,719 women were obtained from 11 biennial postal surveys of Lithuanian health behavior monitoring. Dentate status was assessed by asking about the number of missing teeth. Over the study period, the proportion of men with all teeth increased from 17.5% to 23.0% and the same proportion increased in women—from 12.5% to 19.6%. The prevalence of edentulousness was 2.8% in 2014. The proportion of individuals brushing teeth at least twice a day increased from 14.6% to 31.9% in men and from 33.0% to 58.8% in women. Multivariate logistic regression analysis revealed that older age, lower education, living in rural areas, daily smoking, confectionary consumption (only in women), obesity, no visits to a dentist during the past year, toothache and brushing teeth less than twice a day increased the odds of missing six or more teeth. Efforts should be made to promote good oral hygiene habits, prevent and control behavioral risk factors and increase access to dental care among risk groups.
Health-Related Quality of Life Measured by EQ-5D in Relation to Hospital Stay and Readmission in Elderly Patients Hospitalized for Acute Illness
Authors: Lin Cheng-Fu , Huang Yu-Hui , Ju Li-Ying , Weng Shuo-Chun , Lee Yu-Shan , Chou Yin-Yi , Lin Chu-Sheng , Lin Shih-Yi
Published: July 2020

We evaluated the predictability of self-reported Health-related quality of life (HRQoL) assessed by the 3-level 5-dimensional Euro-Quality of Life tool (EQ-5D-3L) and the EQ-Visual Analog Scale (EQ-VAS) on clinical outcomes of elderly patients who were admitted to an acute geriatric ward. A total of 102 participants (56.9% men) with a median age of 81.0 years (interquartile range or IQR: 76.0–85.3 years) were studied. The age-adjusted Charlson comorbidity index was 5.0 (IQR: 4.0–6.0) with a median length of stay (LOS) of 9.0 days (IQR: 7.0–15.0 days). No death occurred during hospitalization, and within 30 days after discharge, 15 patients were readmitted. During hospitalization, the EQ-5D-3L index was 0.440 at admission and that improved to 0.648 at discharge (p < 0.001). EQ-VAS scores also improved similarly from 60 to 70 (p < 0.001). Physical, cognitive function, frailty parameters (hand grip strength and walking speed), and nutritional status at admission all improved significantly during hospitalization and were related to EQ-5D-3L index or EQ-VAS scores at discharge. After controlling for relevant factors, EQ-5D-3L index at admission was found to be associated with LOS. In addition, EQ-VAS was marginally related to readmission. HRQoL assessment during hospitalization could be useful to guide clinical practice and to improve outcome.
Perceptions of the Food Environment and Access among Predominantly Black Low-Income Residents of Rural Louisiana Communities
Authors: Holston Denise , Stroope Jessica , Greene Matthew , Houghtaling Bailey
Published: July 2020

Food insecurity in rural settings is complex and not fully understood, especially from the perspective of low-income and Black residents. The goal of this study was to use qualitative methods to better understand experiences with food access and perceptions of the food environment among low-income, predominately Black rural Louisiana residents in the United States. Data were collected from focus group discussions (FGD) and focus group intake forms. Study participants were all rural residents eligible to receive at least one nutrition assistance program. FGD questions focused on perceptions of the food environment, with an emphasis on food access. Participants (n = 44) were predominately Black and female. Over half (n = 25) reported running out of food before the end of the month. Major themes included: store choice, outshopping, methods of acquiring foods other than the grocery store, and food insecurity. Concerns around price, quality, and transportation emerged as factors negatively impacting food security. Understanding residents’ perceptions and experiences is necessary to inform contextually appropriate and feasible policy and practice interventions that address the physical environment and social conditions that shape the broader physical food environment in order to achieve equitable food access and food security.
Association between Walking Pace and Diabetes: Findings from the Chilean National Health Survey 2016–2017
Authors: Cigarroa Igor , Espinoza-Sanhueza María José , Lasserre-Laso Nicole , Diaz-Martinez Ximena , Garrido-Mendez Alex , Matus-Castillo Carlos , Martinez-Sanguinetti María Adela , Leiva Ana Maria , Petermann-Rocha Fanny , Parra-Soto Solange , Concha-Cisternas Yeny , Troncoso-Pantoja Claudia , Martorell Miquel , Ulloa Natalia , Waddell Heather , Celis-Morales Carlos
Published: July 2020

Background: Walking pace is a well-known indicator of physical capability, but it is also a strong predictor of type 2 diabetes (T2D). However, there is a lack of evidence on the association between walking pace and T2D, specifically, within developing countries such as Chile. Aim: To investigate the association between self-reported walking pace and T2D in the Chilean adult population. Methods: 5520 Chilean participants (aged 15 to 90 years, 52.1% women) from the Chilean National Health Survey 2016–2017 were included in this cross-sectional study. Both walking pace (slow, average, and brisk) and diabetes data were collected through self-reported methods. Fasting blood glucose (reported in mg/dl) and glycosylated haemoglobin A (HbA1c) scores were determined via blood exams. Results: In the unadjusted model, and compared to people who reported a slow walking pace, those with average and brisk walking pace had lower blood glucose levels (β = −7.74 mg/dL (95% CI: −11.08 to −4.40) and β = −11.05 mg/dL (95% CI: −14.36 to −7.75), respectively) and lower HbA1c (β = −0.34% (95% CI: −0.57 to −0.11) and β= −0.72% (95% CI: −0.94 to −0.49)), respectively. After adjusting for sociodemographic, Body Mass Index and lifestyle factors, the association between glycaemia and HbA1c remained only for brisk walkers. Both the average and brisk walker categories had lower odds of T2D (OR: 0.59 (95% CI: 0.41 to 0.84) and (OR 0.48 (95% CI: 0.30 to 0.79), respectively). Conclusion: Brisk walkers were associated with lower blood glucose and HbA1c levels. Moreover, average to brisk walking pace also showed a lower risk for T2D.
The Effects of Earthquake Experience on Disaster Education for Children and Teens
Authors: Yeon Da-Hye , Chung Ji-Bum , Im Dong-Hyeon
Published: July 2020

The purpose of this study is to examine the factors of disaster experience that impact the effectiveness of disaster education on school students (children and teens). Following the magnitude 5.4 Pohang earthquake in 2017, Pohang City Hall conducted a school earthquake disaster education program over a period of four months (August to November) in 2018. Professors and graduate students from the Ulsan National Institute of Science and Technology taught around 5000 middle and high school students, while also conducting surveys. The experiences of the Pohang earthquake were analyzed and divided into cognitive responses and emotional responses. Students who felt activated emotional responses, surprise and fear, but not joy, tended to have more effective educational experiences. On the other hand, unpleasant emotional reactions, such as anger and sadness, had a negative effect on educational effectiveness. The cognitive response, which is perceived intensity in this research, did not impact educational effectiveness significantly. These results imply that the emotional responses of students are more important than their cognitive responses in providing a disaster education program. This means that even though an earthquake may be small in magnitude and may not cause physical damage, we still need to provide immediate disaster education to the children and teens if they are surprised and afraid of future disasters.
What Are the Determinants of the Decision to Purchase Private Health Insurance in China?
Authors: Wan Guangsheng , Peng Zixuan , Shi Yufeng , Coyte Peter C.
Published: July 2020

The objective of this study was to assess the determinants of the decision to purchase private health insurance (PHI) in China. Nationally representative data from the fourth wave of the China Household Finance Survey from 2017 were used, and the dataset comprised 105,691 individuals aged 18 years or older. The Andersen health services utilization model was used to inform the research. Chi-square tests and logistic regression analyses were used to estimate the decision to purchase PHI. The proportion of the sample that had PHI was small, at 5.06%, but coverage for social basic medical insurance (SBMI) was 90.64%. Among PHI holders, the overwhelming majority (87.40%) also had SBMI. Logistic regression analysis demonstrated that predisposing factors (age, education, marital status, household size), enabling factors (household income, SBMI status, geographical factors, household medical expense, and medical debt), and needs-based factors (health status) were statistically significant determinants of the decision to purchase PHI. This study suggests that the socio-economic circumstances of households play a crucial role in the decision to acquire PHI. The findings may be used by the insurance industry to inform actions to enhance PHI coverage and by policy decision-makers that seek to improve equality in access to PHI.
Determinants of Public-Private Partnership Adoption in Solid Waste Management in Rural China
Authors: Pan Dan , Chen Huan , Zhou Guzhen , Kong Fanbin
Published: July 2020

Rural solid waste management is a severe challenge in China. The Public-Private Partnership (PPP) is an effective method for rural solid waste management. However, policy efforts aimed at stimulating the adoption of PPP in rural solid waste management have been limited in their success. This study aims to empirically investigate the determinants of rural solid waste management PPP adoption in China. First, this study builds a theoretical model that consists of factors related to the institutional environment and market and proposes theoretical hypotheses. Then, using the balanced provincial panel data of 150 samples from 2015 to 2019, this study applies various count regression models and truncated regression models to empirically test the theoretical hypotheses. The results show that provinces with higher fiscal transparency, financial burdens, and market demand tend to adopt more PPP, while provinces with lower per capita GDP and market openness index ratings have a stronger motivation to initiate more PPP. In contrast, investment institutional environment factors have no impact on PPP adoption. To stimulate the development of PPP in rural solid waste management, this study proposed that a good-governed government and a strong market demand are critical foundations, and also a debt-risk prevention and evaluation system should be established to avoid local debt risks resulting from over-adoption of PPP.
Current State and Future Trends: A Citation Network Analysis of the Academic Performance Field
Authors: Martinez-Perez Clara , Alvarez-Peregrina Cristina , Villa-Collar Cesar , Sánchez-Tena Miguel Ángel
Published: July 2020

Background: In recent years, due to its complexity and relevance, academic performance has become a controversial research topic within the health and educational field. The main purposes of this study were to analyze the links between publications and authors via citation networks, to identify the different research areas and to determine the most cited publications. Methods: The publication search was performed through the Web of Science database, using the term “Academic Performance” for a time interval from 1952 to 2019. The software used to analyze the publications was the Citation Network Explorer. Results: We found a total of 16,157 publications with 35,213 citations generated in the network, and 2018 had the highest number of publications of any year. The most cited publication was published in 2012 by Richardson et al. with a citation index score of 352. By using the clustering function, we found nine groups related to different areas of research in this field: health, psychology, psychosociology, demography, physical activity, sleep patterns, vision, economy, and delinquency. Conclusions: The citation network showed the main publications dealing with the different factors that affect academic performance, and it was determined that psychological and psychosocial factors were the most relevant.
Reply to “Comment on Liu et al. ‘Discrepancies of Measured SAR between Traditional and Fast Measuring Systems’ Int. J. Environ. Res. Public Health, 2020, 17, 2111”
Authors: Liu Zicheng , Allal Djamel , Cox Maurice , Wiart Joe
Published: July 2020

The authors of this reply published an article in International Journal of Environmental Research and Public Health and received comments from Douglas and Kuster. Responses are made to these comments with complementary explanations and numerical results.
Tomatine Displays Antitumor Potential in In Vitro Models of Metastatic Melanoma
Authors: Serratì Simona , Porcelli Letizia , Guida Stefania , Ferretta Anna , Iacobazzi Rosa Maria , Cocco Tiziana , Maida Immacolata , Tamasi Gabriella , Rossi Claudio , Manganelli Michele , Tommasi Stefania , Azzariti Amalia , Guida Gabriella
Published: July 2020

There is a growing interest in the cytotoxic effects of bioactive glycoalkaloids, such as α-tomatine on tumor cells. Here, for the first time, we determine the antitumor potential of tomatine, a mixture of α-tomatine and dehydrotomatine, in metastatic melanoma (MM) cell lines harboring different BRAF and MC1R variants. We performed cytotoxicity experiments and annexin-V/propidium iodide staining to assess the apoptotic/necrotic status of the cells. ER stress and autophagy markers were revealed by Western Blot, whereas antiangiogenic and vascular-disrupting effects were evaluated through a capillary tube formation assay on matrigel and by ELISA kit for VEGF release determination. Cell invasion was determined by a Boyden chamber matrigel assay. Tomatine reduced 50% of cell viability and induced a concentration-dependent increase of apoptotic cells in the range of 0.5–1 μM in terms of α-tomatine. The extent of apoptosis was more than two-fold higher in V600BRAF-D184H/D184H MC1R cells than in BRAF wild-type cells and V600BRAF-MC1R wild-type cell lines. Additionally, tomatine increased the LC3I/II autophagy marker, p-eIF2α, and p-Erk1/2 levels in BRAF wild-type cells. Notably, tomatine strongly reduced cell invasion and melanoma-dependent angiogenesis by reducing VEGF release and tumor-stimulating effects on capillary tube formation. Collectively, our findings support tomatine as a potential antitumor agent in MM.
Regulation of Drosophila Hematopoiesis in Lymph Gland: From a Developmental Signaling Point of View
Authors: Lan Wenwen , Liu Sumin , Zhao Long , Su Ying
Published: July 2020

The Drosophila hematopoietic system is becoming increasingly attractive for its simple blood cell lineage and its developmental and functional parallels with the vertebrate system. As the dedicated organ for Drosophila larval hematopoiesis, the lymph gland harbors both multipotent stem-like progenitor cells and differentiated blood cells. The balance between progenitor maintenance and differentiation in the lymph gland must be precisely and tightly controlled. Multiple developmental signaling pathways, such as Notch, Hedgehog, and Wnt/Wingless, have been demonstrated to regulate the hematopoietic processes in the lymph gland. Focusing on blood cell maintenance and differentiation, this article summarizes the functions of several classic developmental signaling pathways for lymph gland growth and patterning, highlighting the important roles of developmental signaling during lymph gland development as well as Drosophila larval hematopoiesis.
Drug Discovery Targeting the Disorder-To-Order Transition Regions through the Conformational Diversity Mimicking and Statistical Analysis
Authors: Na Insung , Choi Sungwoo , Son Seung Han , Uversky Vladimir N. , Kim Chul Geun
Published: July 2020

Intrinsically disordered proteins exist as highly dynamic conformational ensembles of diverse forms. However, the majority of virtual screening only focuses on proteins with defined structures. This means that computer-aided drug discovery is restricted. As a breakthrough, understanding the structural characteristics of intrinsically disordered proteins and its application can open the gate for unrestricted drug discovery. First, we segmented the target disorder-to-order transition region into a series of overlapping 20-amino-acid-long peptides. Folding prediction generated diverse conformations of these peptides. Next, we applied molecular docking, new evaluation score function, and statistical analysis. This approach successfully distinguished known compounds and their corresponding binding regions. Especially, Myc proto-oncogene protein (MYC) inhibitor 10058F4 was well distinguished from others of the chemical compound library. We also studied differences between the two Methyl-CpG-binding domain protein 2 (MBD2) inhibitors (ABA (2-amino-N-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-acetamide) and APC ((R)-(3-(2-Amino-acetylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester))). Both compounds bind MBD2 through electrostatic interaction behind its p66α-binding site. ABA is also able to bind p66α through electrostatic interaction behind its MBD2-binding site while APC-p66α binding was nonspecific. Therefore, structural heterogeneity mimicking of the disorder-to-order transition region at the peptide level and utilization of the new docking score function represent a useful approach that can efficiently discriminate compounds for expanded virtual screening toward intrinsically disordered proteins.
Modulating the Crosstalk between the Tumor and Its Microenvironment Using RNA Interference: A Treatment Strategy for Hepatocellular Carcinoma
Authors: Mroweh Mariam , Decaens Thomas , Marche Patrice N , Macek Jilkova Zuzana , Clément Flora
Published: July 2020

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy with one of the highest mortality rates among solid cancers. It develops almost exclusively in the background of chronic liver inflammation, which can be caused by viral hepatitis, chronic alcohol consumption or an unhealthy diet. Chronic inflammation deregulates the innate and adaptive immune responses that contribute to the proliferation, survival and migration of tumor cells. The continuous communication between the tumor and its microenvironment components serves as the overriding force of the tumor against the body’s defenses. The importance of this crosstalk between the tumor microenvironment and immune cells in the process of hepatocarcinogenesis has been shown, and therapeutic strategies modulating this communication have improved the outcomes of patients with liver cancer. To target this communication, an RNA interference (RNAi)-based approach can be used, an innovative and promising strategy that can disrupt the crosstalk at the transcriptomic level. Moreover, RNAi offers the advantage of specificity in comparison to the treatments currently used for HCC in clinics. In this review, we will provide the recent data pertaining to the modulation of a tumor and its microenvironment by using RNAi and its potential for therapeutic intervention in HCC.