bluuebunny/crossref_metadata_2025 huggingface dataset:
Biosimilars in der Gastroenterologie
Authors: Dejaco Clemens , Novacek Gottfried , Haas Thomas , Fuchssteiner Harry , Moschen Alexander , Högenauer Christoph , Petritsch Wolfgang
Published: January 2020

Biologika nehmen eine herausragende Rolle in der Therapie chronisch-entzündlicher Darmerkrankungen (CED) ein. Diese aus lebenden Zellen biotechnologisch hergestellten Antikörper (Ak) ermöglichen zunehmend selektive antientzündliche Behandlungsansätze, wobei deren Produktion und Zulassung einem komplexen und kostenintensiven Entwicklungsprozess unterliegen. Mit Patentablauf einzelner Biologika kommen seit einigen Jahren nun zunehmend Biosimilars, ebenso biotechnologisch produzierte Nachfolgepräparate, auf den Markt und führen zu einer zunehmenden Präparatevielfalt bei sinkenden Kosten für das Gesundheitssystems. Das vorliegende Positionspapier der Arbeitsgruppe (AG) CED der Österreichischen Gesellschaft für Gastroenterologie und Hepatologie (ÖGGH) versucht mit dieser Entwicklung aufkommende Fragen betreffend Wirksamkeit, Sicherheit, Präparatewechsel (Switch) und Verschreibungsgebarung zu beantworten, um eine höchstmögliche Patientensicherheit auch zukünftig zu gewährleisten.
Editorial
Authors: Mansfield-Devine Steve
Published: January 2020

At the time of writing, the California Computer Privacy Act (CCPA) has been in effect for little more than a week – too soon to judge its true impact, although during its gestation it provoked much dismay among many large tech firms, most of them based in the same state.
Preventive medicine is the best method for computer hygiene
Authors: Barak Liron
Published: January 2020

It's amazing just how closely computer viruses – and how we detect and remedy them – mimic the real thing. By looking at how biological viruses manifest and spread – and how we combat them, we can inform our approach to doing so more effectively in the digital world.

It's amazing just how closely computer viruses – and how we detect and remedy them – mimic the real thing.

There are striking similarities between biological viruses and their cyber equivalents. Just as your immune system reacts to viruses by detecting their genetic code, traditional cyber security defences depend on their ability to identify the genetic codes of the malware. Liron Barak of BitDam suggests that looking at how biological viruses manifest and spread can inform our approach to defending more effectively in the digital world.
Spinozistic Selves
Authors: NEWLANDS SAMUEL
Published: January 2020

Spinoza'sEthicspromises a path for sweeping personal transformations, but his accounts face two sets of overarching problems. The first concerns his peculiar metaphysics of action and agents; the second his apparent neglect of the very category of persons. Although these are somewhat distinct concerns, they have a common, unified solution in Spinoza's system that is philosophically rich and interesting, both in its own right and in relation to contemporary work in moral philosophy. After presenting the core of the problem facing Spinoza's action theory, I turn to his overlooked account of selves, one that can be illuminated by contemporary work on so-called deep-self theories. I then show how Spinoza's distinctive account of selves prevents his action theory from collapsing into metaphysical incoherence, and conclude with an implication for Spinoza's broader account of transformation.
Naïve Normativity: The Social Foundation of Moral Cognition
Authors: ANDREWS KRISTIN
Published: January 2020

To answer tantalizing questions such as whether animals are moral or how morality evolved, I propose starting with a somewhat less fraught question: do animals have normative cognition? Recent psychological research suggests that normative thinking, or ought-thought, begins early in human development. Recent philosophical research suggests that folk psychology is grounded in normative thought. Recent primatology research finds evidence of sophisticated cultural and social learning capacities in great apes. Drawing on these three literatures, I argue that the human variety of social cognition and moral cognition encompass the same cognitive capacities and that the nonhuman great apes may also be normative beings. To make this argument, I develop an account of animal social norms that shares key properties with Cristina Bicchieri's account of social norms but which lowers the cognitive requirements for having a social norm. I propose a set of four early developing prerequisites implicated in social cognition that make up what I call naïve normativity: (1) the ability to identify agents, (2) sensitivity to in-group/out-group differences, (3) the capacity for social learning of group traditions, and (4) responsiveness to appropriateness. I review the ape cognition literature and present preliminary empirical evidence supporting the existence of social norms and naïve normativity in great apes. While there is more empirical work to be done, I hope to have offered a framework for studying normativity in other species, and I conclude that we should be open to the possibility that normative cognition is yet another ancient cognitive endowment that is not human-unique.
Outcome of pediatric emergency mental health visits: incidence and timing of suicide
Authors: Lee Joshua , Black Tyler , Meckler Garth , Doan Quynh
Published: January 2020

Objectives

To determine the incidence, risk, and timing of mortality (unnatural and natural causes) among youth seen in a pediatric emergency department (ED) for mental health concerns, compared with matched non–mental health ED controls.

Methods

This was a retrospective cohort study conducted at a quaternary pediatric ED in British Columbia. All visits for a mental health related condition between July 1st, 2005, and June 30th, 2015, were matched on age, sex, triage acuity, socioeconomic status, and year of visit to a non–mental health control visit. Mortality outcomes were obtained from vital statistics data through December 31st, 2016 (cumulative follow-up 74,390 person-years).

Results

Among all cases in our study, including 6,210 youth seen for mental health concerns and 6,210 matched controls, a total of 13 died of suicide (7.5/100,000 person-years) and 33 died of suicide or indeterminate causes (44/100,000 person-years). All-cause mortality was significantly lower among mental health presentations (121.3/100,000 v. 214.5/100,000 person-years; hazard ratio [HR], 0.54; 95% confidence interval [CI], 0.37–0.78). The median time from initial emergency visit to suicide was 5.2 years (interquartile range, 4.2–7.3). Among mental health related visits, risk of death by suicide or indeterminate cause was three-fold that of matched controls (HR, 3.05 95%CI, 1.37–6.77).

Conclusions

While youth seeking emergency mental health care are at increased risk of death by unnatural causes, their overall mortality risk is lower than non–mental health controls. The protracted duration from initial presentation to suicide highlights the need for long-term surveillance and preventative care for youth seen in the ED for all mental health concerns.
Building bridges between a community and an academic medical center via community tours
Authors: Irby Megan B. , Moore Keena R. , Hamlin DeWanna , Brown Olivia , Trejo Grisel , Summers Phillip , Daniel Stephanie , Skelton Joseph A. , Lischke Michael , Rhodes Scott D.
Published: January 2020

Academic medical centers (AMCs) face challenges in conducting research among traditionally marginalized communities due to long-standing community mistrust. Evidence suggests that some AMC faculty and staff lack an understanding of the history of distrust and social determinants of health (SDH) affecting their communities. Wake Forest Clinical and Translational Science Institute Program in Community Engagement (PCE) aims to build bridges between communities and Wake Forest Baptist Health by equipping faculty, clinicians, administrators, and staff (FCAS) with a better understanding of SDH. The PCE collaborated with community partners to develop and implement community tours to improve cross-community AMC understanding and communication, enhance knowledge of SDH, and build awareness of community needs, priorities, and assets. Nine day-long tours have been conducted with 92 FCAS. Tours included routes through under-resourced neighborhoods and visits to community assets. Participant evaluations assessed program quality; 89% reported enhanced understanding of access-to-care barriers and how SDH affect health; 86% acknowledged the experience would improve future interactions with participants and patients; and 96% agreed they would recommend the tour to colleagues. This work supports the use of community tours as a strategy to improve cross-community AMC communication, build trust, and raise awareness of community needs, priorities, and assets.
MOMENTS OF RANDOM MULTIPLICATIVE FUNCTIONS, I: LOW MOMENTS, BETTER THAN SQUAREROOT CANCELLATION, AND CRITICAL MULTIPLICATIVE CHAOS
Authors: HARPER ADAM J.
Published: January 2020

We determine the order of magnitude of$\mathbb{E}|\sum _{n\leqslant x}f(n)|^{2q}$, where$f(n)$is a Steinhaus or Rademacher random multiplicative function, and$0\leqslant q\leqslant 1$. In the Steinhaus case, this is equivalent to determining the order of$\lim _{T\rightarrow \infty }\frac{1}{T}\int _{0}^{T}|\sum _{n\leqslant x}n^{-it}|^{2q}\,dt$.

In particular, we find that$\mathbb{E}|\sum _{n\leqslant x}f(n)|\asymp \sqrt{x}/(\log \log x)^{1/4}$. This proves a conjecture of Helson that one should have better than squareroot cancellation in the first moment and disproves counter-conjectures of various other authors. We deduce some consequences for the distribution and large deviations of$\sum _{n\leqslant x}f(n)$.

The proofs develop a connection between$\mathbb{E}|\sum _{n\leqslant x}f(n)|^{2q}$and the$q$th moment of a critical, approximately Gaussian, multiplicative chaos and then establish the required estimates for that. We include some general introductory discussion about critical multiplicative chaos to help readers unfamiliar with that area.
Political Machines and the Institutional Background of Economic Miracles
Authors: Popa Mircea
Published: January 2020

Some of the world's most notable economic miracles were accompanied by corruption, rent-seeking and clientelism, which is puzzling given the wide agreement on the importance of good institutions for growth. This article builds on the experiences of the US, Japan, Italy, South Korea and China to argue that these institutional maladies can be the natural outcomes of governance structures that facilitate growth. The theoretical argument revolves around the nature and strategies of dominant political organizations. Party machines can sometimes broker compensatory transfers that allow entrenched interests to profit from economic change, rather than be hurt by it, by the logic of the political Coase theorem. Transfers which are inefficient in most settings can therefore, if properly rationed and targeted, alleviate some of the key strategic impediments to growth identified by the political economy literature.
Cross-Ethnic Voting: An Index of Centripetal Electoral Systems
Authors: Reilly Benjamin
Published: January 2020

Centripetal approaches to democracy in divided societies seek to promote inter-ethnic accommodation and moderation by making politicians dependent on the electoral support of groups other than their own base. Such cross-ethnic voting stands in contrast to situations where politicians need only the support of their own co-ethnics to win elections. This distinction can be used to evaluate the utility of centripetal electoral systems in promoting voting across ethnic divides. To do so, this article begins by considering some critiques of centripetalism, showing that cross-ethnic voting is more common in both institutional design and actual practice than some critics believe. It then moves on to examine cases of cross-ethnic voting via ethnically designated party lists, cross-regional party formation rules, at-large communal or sectoral seat reservations, and uni-directional vote-pooling, using these cases to construct an index of strong, moderate and weak centripetal electoral systems.
Nutritional status coverage trend registered in the SISVAN web in seven municipalities of the Zona Da Mata Mineira, Brazil, from 2008 to 2017, and its association with socio-economic, demographic and organisation of health system variables
Authors: Gonçalves Irene da Silva Araújo , Pereira Patrícia Feliciano , Silva Mariana Belcavelo Lino , Ladeira Fernanda Batista , Moreira Tiago Ricardo , Cotta Rosângela Minardi Mitre , Costa Glauce Dias da
Published: January 2020

We analysed the coverage trend of the evaluation of the nutritional status of users of public health services registered in the Food and Nutrition Surveillance System (SISVAN) between 2008 and 2017 in seven municipalities and verified the association of the coverage trend with the socio-economic, demographic and organisational aspects of health system variables. It is an ecological time-series study performed with secondary data extracted from health information systems. Descriptive statistics, linear regression model and repeated measures analysis were performed. The coverage of evaluation of nutritional status was low over the period. Five municipalities showed a tendency to increase coverage, although small, while two remained stable. The highest annual variation in coverage increase was concentrated in the group of pregnant women and the lowest in adolescents and older adults. There was a downward trend in follow-ups from the Bolsa Family Programme and a trend towards increased follow-ups from SUS Primary Care (e-SUS AB). SISVAN coverage was positively associated with the proportion of rural population (P≤ 0·001) and coverage of community health agents (P< 0·001); and negatively associated with total population (P< 0·001), demographic density (P= 0·006) and gross domestic product per capita (P= 0·008). Despite the tendency to increase coverage in some municipalities, SISVAN still presents low coverage of nutritional status assessment, which compromises population monitoring. Knowing the factors that influence the coverage can subsidise the elaboration of strategies for its expansion.
The Impact of Adjacent Laws on Implementing Violence Against Women Laws: Legal Violence in the Lives of Costa Rican Women
Authors: Adamson Erin , Menjívar Cecilia , Walsh Shannon Drysdale
Published: January 2020

Most scholarship addressing implementation gaps of violence against women (VAW) laws focuses on countries with high levels of violence in the lives of women—accompanied by weak policing and judicial responses. These studies tend to argue that the most egregious forms of political or social violence explain this gap. However, there has been little attention to countries with lower levels of gender-based violence and relatively responsive state institutions. We analyze the application of VAW laws in Costa Rica, with a focus on the impact of adjacent laws, or laws that are seemingly unrelated to VAW laws but are applied in tandem with and often in conflict with VAW laws. Based on a decade of fieldwork in Costa Rica, we argue that adjacent laws on land, labor, and immigration can be leveraged in ways that undermine the interpretation and implementation of VAW laws. These failures constitute legal violence: the normalized but cumulatively injurious effects of laws that can result in various forms of violence. While legal violence causes implementation gaps in almost every country, our case study reveals that the underlying sociolegal system upon which these laws rest contributes to a significant gap between VAW laws and practice.
(Un)Changing Rates of Pro Se Litigation in Federal Court
Authors: Gough Mark D. , Taylor Poppe Emily S.
Published: January 2020

There is widespread concern among scholars, court actors, and policy makers that the number of pro se litigants is increasing. However, we have little empirical evidence of the scope of pro se litigation, especially in the federal court system. Using data from the Administrative Office of the U.S. Courts on all civil case filings since 1999, we investigate the prevalence and rate of pro se litigation in federal district courts. We find no evidence of a dramatic rise in pro se litigation, but we document substantial variation in rates of pro se litigation by type of case and circuit of filing. The results have implications for our understanding of self-representation and for the development of policies addressing access to civil justice.
Do we need a theory of legitimate expectations?
Authors: Tomlinson Joe
Published: January 2020

In recent years, it has become common to see claims that the doctrine of legitimate expectations has no sufficiently defined purpose, and that administrative law scholars should do more theoretical work to bring coherence to this area of law. In this paper, I suggest this ‘conceptual critique’ of legitimate expectations is misplaced and that, instead, it reveals a much wider failing of contemporary administrative law scholarship. First, I show how there has not yet been, and is unlikely to be, a satisfactory answer to the conceptual critique. Following on from this premise, I suggest that the assumptions underlying the conceptual critique are faulty and, administrative lawyers need to fundamentally alter and expand how they study legitimate expectations. The aim now, I argue, must be to move towards providing an account of the practice of legitimate expectations in the wider context of public administration. My specific argument in this paper is thus a case for a significant reorientation and an expansion of the study of how law protects legitimate expectations, but the wider suggestion is that the same shift is required in administrative law scholarship generally.
Losing the local? Public participation and legal expertise in planning law
Authors: Abbot Carolyn
Published: January 2020

Local community opposition to environmentally significant development proposals is commonplace, with environmental issues often at the forefront of community concerns. Whilst the development consent system provides multiple opportunities for local community groups to participate in the initial decision-making process, a legal commitment to such participation ensures neither its quality nor its effectiveness. This is especially so for local group ‘have-nots’ who lack resource and expertise, and whose focus on locally-based objections can delegitimise their valid and often broader concerns about the proposed development. This paper argues that access to legal expertise plays a significant role in promoting principles of fairness and competence in participation by helping shape local opposition views in a way that is both understood and accepted as valid by the planning system. Whilst there are important and valuable sources of advice and support currently available, many local groups find themselves in the position of having to raise considerable funds to pay for the legal expertise they need. This unsatisfactory position needs to be addressed if local groups are to meaningfully engage with the planning process.
Lorenzo Valla's Critique of Jurisprudence, the Discovery of Heraldry, and the Philology of Images
Authors: Mackenzie Jennifer Kathleen
Published: January 2020

In 1433, Lorenzo Valla attacked contemporary jurisprudence with a treatise attributed to the civilian lawyer Bartolus of Saxoferrato, the “De insigniis et armis.” This was considered Europe's first treatise on heraldry until a team of legal historians questioned its subject matter and authenticity. Meanwhile, visual culture continues to be seen as peripheral to Valla's critical agenda. This article proposes that Valla engaged images as manifestations of social authority and historical change. His epistle against Bartolus participates in an intellectual history of intersections between philology, antiquarianism, and the anthropology of images in which heraldry has been defined.
From Islamists to Muslim Democrats: The Case of Tunisia’s Ennahda
Authors: GREWAL SHARAN
Published: January 2020

What drives some Islamists to become “Muslim Democrats,” downplaying religion and accepting secular democracy? This article hypothesizes that one channel of ideological change is migration to secular democracies. Drawing on an ideal point analysis of parliamentary votes from the Tunisian Islamist movement Ennahda, I find that MPs who had lived in secular democracies held more liberal voting records than their counterparts who had lived only in Tunisia. In particular, they were more likely to defend freedom of conscience and to vote against enshrining Islamic law in the constitution. Interviews with several of these MPs demonstrate that they recognize a causal effect of their experiences abroad on their ideologies, and provide support for three distinct mechanisms by which this effect may have occurred: socialization, intergroup contact, and political learning.
Anti-Competition Regulation
Authors: Fleming Anne
Published: January 2020

Looking across the long twentieth century, this article tracks the rise and fall of one form of anti-competition regulation: the certificate of public convenience. Designed to curb “destructive competition” in certain industries, such as transportation and banking, certificate laws prevented firms from entering those industries unless they could convince regulators that they would satisfy an unmet public demand for goods or services. This history highlights how lawmakers used similar techniques in governing infrastructure and finance—two fields that are not often studied together. It also shows that state regulation both prefigured legal change at the federal level and then lagged behind it, suggesting that different dynamics have been in play at each level of governance in devising competition policy over the last century.
Universality Without Normativity: Interpreting the Demand of Kantian Judgements of Taste
Authors: Harbin R. Kathleen
Published: January 2020

Kant claims that we demand the agreement of others when making judgements of taste. I argue that this claim is part of an explanation of how the phenomenology of familiar aesthetic judgements supports his contention that judgements of taste are universal. Kant's aesthetic theory is plausible only if we reject the widespread contention that this demand is normative. I offer a non-normative reading of Kantian judgements of taste based on a close reading of the Analytic and Deduction, then argue against the three prominent normative interpretations, which force us to attribute to Kant a position that he did not accept.
Third-Stream Orientalism: J. N. Farquhar, the Indian YMCA's Literature Department, and the Representation of South Asian Cultures and Religions (ca. 1910–1940)
Authors: Fischer-Tiné Harald
Published: January 2020

This article reconstructs the history of the Indian YMCA's Orientalist knowledge production in an attempt to capture a significant, if forgotten, transitional moment in the production and dissemination of scholarship on the religions and cultures of the Indian subcontinent. The YMCA's three Orientalist book series examined here flourished from the 1910s to the 1930s and represent a kind of third-stream approach to the study of South Asia. Inspired by the Christian fulfillment theory, “Y Orientalism” was at pains to differentiate itself from older polemical missionary writings. It also distanced itself from the popular “spiritual Orientalism” advocated by the Theosophical Society and from the philologically inclined “academic Orientalism” pursued in the Sanskrit departments of Western universities. The interest of the series’ authors in the region's present and the multifarious facets of its “little traditions,” living languages, arts, and cultures, as well as their privileging of knowledge that was generated “in the field” rather than in distant Western libraries, was unusual. Arguably, it anticipated important elements of the “area studies” approach to the Indian subcontinent that became dominant in Anglophone academia after the Second World War.
Effect of fermented whey with a probiotic bacterium on gut immune system
Authors: García Gisela , Agosto María Emilia , Cavaglieri Lilia , Dogi Cecilia
Published: January 2020

The aim of the work presented in this Research Communication was to evaluate the effect of fermented whey (FW) with Lactobacillus rhamnosus RC007 in a mice model. BALB/c mice were divided into three groups: control group: animals received orally 0.1 ml of phosphate buffered saline (PBS); FW group: animals received orally 0.1 ml of FW; whey (W) group: animals received orally 0.1 ml of W without fermentation with probiotic bacterium. After 10 d mice were sacrificed. Small intestines were collected for determination of IL-10; IL-6, TNFα, goblet cells and intraepithelial lymphocytes. Increases of all the cytokines assayed were observed in mice that received FW compared to control and W group. The ratio between the anti and pro-inflammatory cytokines (IL-10/TNFα) increased in the group of mice that received FW. The number of goblet cells and intraepithelial lymphocytes were also increased in animals that received FW. The results showed that FW with L. rhamnosus RC007 was able to stimulate and to modulate mouse immune system. Whey fermented by this probiotic bacterium is an interesting alternative for development of a new food additive for pig production, taking advantage of the beneficial properties of probiotic bacterium and the nutritional properties of whey.
The restoration of the Buganda Kingdom Government 1986–2014: culture, contingencies, constraints
Authors: Kasfir Nelson
Published: January 2020

The restoration of the Kabaka of Buganda a quarter century after its abolition was the unexpected and contested product of different views of Ganda social structure that had emerged over several centuries. Competing groups, despite acting on contradictory cultural principles, overcame the suspicion of a newly empowered central government. Selective recall of cultural norms and adroit organisational tactics of the individuals who recreated the Buganda Kingdom Government allowed them to surpass their rivals and become the main Ganda interlocutors with the central government. They persuaded the central government to restore the king, though not the kingdom. The compromise they struck permitted the king to be cultural, but not political. Not only did that raise further questions about the meaning of Ganda culture, it constrained the Buganda Kingdom Government's ability to promote Ganda interests with the central government and on occasion reduced its support from the Ganda public in the years following restoration.
Rumours in war: Boko Haram and the politics of suspicion in French–Cameroon relations
Authors: Orock Rogers
Published: January 2020

Cameroon's autocrat, Paul Biya, declared war on Boko Haram in 2014. Using a variety of ethnographic materials, this article examines the politics of rumours and conspiracy theories that have defined the popular response to this war in Cameroon. It underlines the mobilising force of these rumours on intra-elite struggles within the national context as well as on international relations, particularly on French–Cameroon relations. I argue that rumour-mongering is a central mode of production of suspicion in times of war and social crisis. Yet, the current rumours in the wake of the war against Boko Haram in Cameroon are inscribed within a historical framework of a state-directed politics of paranoia that seeks to define ‘enemies of destabilisation’. In the end, this politics of suspicion also works to bring otherwise disaffected Cameroonians to support the autocratic Paul Biya as a victim of foreign plots for regime change in Cameroon.
A new species of Sunamphitoe Bate, 1857 (Crustacea: Amphipoda: Ampithoidae) from Hokkaido, Japan
Authors: Kodama Masafumi , Onitsuka Toshihiro , Kawamura Tomohiko
Published: January 2020

A new species of ampithoid amphipod, Sunamphitoe gigantea sp. nov., is described from Katsurakoi, Hokkaido, Japan. The new species most closely resembles S. eoa, but can be distinguished from it by the shorter flagellum of antenna 1, the maxilla 1 inner plate that bears two slender setae, the short dactylus of male gnathopod 2, and the presence of a group of long setae on anterior margins of pereopods 3 and 4 bases. Nucleotide sequences of mitochondrial cytochrome c oxidase subunit I obtained from the type specimens also differentiated this new species from the congeners. Ontogenetic morphological changes of the male gnathopod 2 are briefly discussed.
The real advantages of the simulation solution to the problem of natural evil
Authors: CRUMMETT DUSTIN
Published: January 2020

Nick Bostrom has famously defended the credibility of the simulation hypothesis – the hypothesis that we live in a computer simulation. Barry Dainton has recently employed the simulation hypothesis to defend the ‘simulation solution’ to the problem of natural evil. The simulation solution claims that apparently natural evils are in fact the result of wrong actions on the part of the people who create our simulation. In this way, it treats apparently natural evils as actually being moral evils, allowing them to be explained via the free will theodicy. Other theodicies which assimilate apparently natural evils to moral ones includeFall theodicies, which attribute apparently natural evils to the biblical Fall, anddiabolical theodicies, which attribute them to the activity of demons. Unfortunately, Dainton fails to give compelling reasons for preferring the simulation solution to Fall or diabolical theodicies. He gives one argument against diabolical theodicies, but it has no force against their best version, and he does not discuss Fall theodicies at all. In this article, I attempt to rectify this. I discuss several problems faced by Fall and diabolical theodicies which the simulation solution avoids. These provide some reason to prefer the simulation solution to these alternatives.
Divine knowledge as direct awareness: a defence of Alston
Authors: SAEEDIMEHR MOHAMMAD
Published: January 2020

In his ‘Does God have beliefs?’, William Alston argues for an intuitive construal of the nature of Divine knowledge according to which God's knowledge consists in His direct awareness without any beliefs. Recently, Travis Dickinson has raised some objections to Alston's view and has developed an alternative account of God's knowledge as His acquaintance with a fact, a corresponding thought or belief, and a correspondence between these two. In this article, I respond to Dickinson's objections and show that there is no reason to favour his acquaintance construal of God's knowledge over Alston's intuitive view of the nature of God's knowledge.
Longitudinal study of Caribbean pine elucidates the role of 4-allylanisole in patterns of chemical resistance to bark beetle attack
Authors: Hammer Austin J. , Bower Nathan W. , Snyder Aaron I. , Snyder Zachary N. , Archila Fredy L. , Snyder Marc A.
Published: January 2020

Southern pine beetles (Dendroctonus frontalis Zimmermann) and symbiotic fungi are associated with mass mortality in stands of Caribbean pine (Pinus caribaea Morelet). This study provides a 12.7-year assessment of semiochemical mediation between southern pine beetle and Caribbean pine in relation to concentrations of 4-allylanisole (estragole, methyl chavicol) and monoterpenes measured by gas chromatography–mass spectrometry in different seasons in premontane and coastal pine stands of Belize and Guatemala. Individual trees and stands with >2.5% (relative mass %) of 4-allylanisole in the xylem oleoresin exhibited significantly less beetle-induced mortality than those with <2.5%. Changes in relative levels of 4-allylanisole and monoterpenes during this study are consistent with seasonal temperature and cumulative water deficit effects and suggest bark beetle attack of P. caribaea may intensify in the future.
Crystal structure of pantoprazole sodium sesquihydrate Form I, C16H14F2N3O4SNa(H2O)1.5
Authors: Gonzalez Diana , Golab Joseph T. , Kaduk James A. , Gindhart Amy M. , Blanton Thomas N.
Published: January 2020

The crystal structure of pantoprazole sodium sesquihydrate has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional techniques. Pantoprazole sodium sesquihydrate crystallizes in space groupPbca(#61) witha= 33.4862(6),b= 17.29311(10),c= 13.55953(10) Å,V= 7852.06(14) Å3, andZ= 16. The crystal structure is characterized by layers parallel to thebc-plane. One layer contains the Na coordination spheres. The two independent sodium ions are trigonal bipyramidal and octahedral. The NaO3N2and NaO4N2coordination spheres share an edge to form pairs. The sodium bond valence sums are 1.17 and 1.15. The difluoromethyl groups are probably disordered. Two water molecules act as hydrogen bond donors to pyridine nitrogen atoms and sulfoxide oxygen atoms. The third water molecule participates in bifurcated hydrogen bonds, but one of its hydrogen atoms does not participate in hydrogen bonds. The powder pattern is included in the Powder Diffraction File™ as entry 00-065-1424.
Cross-sectional serosurvey of Coxiella burnetii in healthy cattle and sheep from extensive grazing system in central Italy
Authors: Barlozzari G. , Sala M. , Iacoponi F. , Volpi C. , Polinori N. , Rombolà P. , Vairo F. , Macrì G. , Scarpulla M.
Published: January 2020

A cross-sectional survey was carried out to estimate the seroprevalence of Coxiella burnetii in extensively grazed cattle and sheep from central Italy and to identify the related risk factors. Data on notified human Q fever cases in the area were also collected and described. A two-stage cluster sampling was performed. A total of 5083 animals (2210 cattle; 2873 sheep) belonging to 186 farms (92 herds; 94 flocks) were tested for the presence of antibodies against C. burnetii using a commercial enzyme-linked immunosorbent assay kit. The prevalence at the animal-level resulted three times higher in sheep compared to cattle (37.8% vs. 12.0%; χ2 = 270.10, P < 0.001). The prevalence at the herd-level was also higher in sheep than in cattle (87.2% vs. 68.5%; χ2 = 9.52, P < 0.01). The multivariate analysis showed a higher risk of seropositivity for cattle aged 67–107 months (OR 2.79, 95% CI 1.86–4.18), cattle >107 months of age (OR 2.07, 95% CI 1.36–3.14) and mixed breed cattle (OR 1.74, 95% CI 1.11–2.72). A herd size >92 animals was recognized as herd-level risk factor in cattle (OR 6.88, 95% CI 1.67–28.37). The risk of being seropositive was double in sheep belonging to flocks >600 animals (odds ratio (OR) 2.04, 95% CI 1.63–2.56). Sheep were confirmed to be the most exposed species. Nevertheless, the prevalence observed in cattle also suggests the potential involvement of this species in the circulation of the pathogen in the area. Seven confirmed human Q fever cases were reported. In five out of seven cases there was at least one exposed herd within a 5 km buffer. Even though the source of the infection was not identified, the possibility of C. burnetii circulating in the livestock and human population in the study area cannot be overlooked. The integration between veterinary and human surveillance will be crucial to understand the spread of this zoonosis and to support the adoption of appropriate control measures.
Exceptionality and derived environment effects: a comparison of Korean and Turkish
Authors: Chong Adam J.
Published: January 2020

Morphologically derived environment effects (MDEEs) are well-known examples where phonotactic patterns in the lexicon mismatch with what is allowed at morphological boundaries – alternations. Analyses of MDEEs usually assume that the alternation is morphologically general, and that the sequences ‘repaired’ across morpheme boundaries are phonotactically well-formed in the lexicon. This paper examines the phonotactic patterns in the lexicon of two languages with MDEEs: Korean palatalisation and Turkish velar deletion. I show that Korean heteromorphemic sequences that undergo palatalisation are underattested in the lexicon. A computational learner learns a markedness constraint that drives palatalisation, suggesting a pattern of exceptional non-undergoing. This contrasts with Turkish, where the relevant constraint motivating velar deletion at the morpheme boundary is unavailable from phonotactic learning, and where the alternation is an example of exceptional triggering. These results indicate that MDEEs are not a unitary phenomenon, highlighting the need to examine these patterns in closer quantitative detail.
Learning biases in opaque interactions
Authors: Prickett Brandon
Published: January 2020

This study uses an artificial language learning experiment and computational modelling to test Kiparsky's claims about Maximal Utilisation and Transparency biases in phonological acquisition. A Maximal Utilisation bias would prefer phonological patterns in which all rules are maximally utilised, and a Transparency bias would prefer patterns that are not opaque. Results from the experiment suggest that these biases affect the learnability of specific parts of a language, with Maximal Utilisation affecting the acquisition of individual rules, and Transparency affecting the acquisition of rule orderings. Two models were used to simulate the experiment: an expectation-driven Harmonic Serialism learner and a sequence-to-sequence neural network. The results from these simulations show that both models’ learning is affected by these biases, suggesting that the biases emerge from the learning process rather than any explicit structure built into the model.
Constraints on contrast motivate nasal cluster dissimilation
Authors: Stanton Juliet
Published: January 2020

Many languages exhibit nasal cluster dissimilation, in which an illicit sequence of nasal–stop clusters is modified in some way (e.g. NC1VNC2 → N1VNC2). This article discusses generalisations in the typology of nasal cluster dissimilation, and claims that nasal cluster dissimilation is driven by constraints on contrast distinctiveness: it occurs preferentially in those environments where the first NC is most confusable with a plain nasal consonant. I propose an analysis that appeals to auditory factors, and provide acoustic and perceptual evidence that is consistent with it.
Valuing humane lives in two-level utilitarianism
Authors: Delon Nicolas
Published: January 2020

I examine the two-level utilitarian case for humane animal agriculture (by R. M. Hare and Gary Varner) and argue that it fails on its own terms. The case states that, at the ‘intuitive level’ of moral thinking, we can justify raising and killing animals for food, regarding them as replaceable, while treating them with respect. I show that two-level utilitarianism supports, instead, alternatives to animal agriculture. First, the case for humane animal agriculture does not follow from a commitment to two-level utilitarianism combined with a commitment to respecting animal lives. Second, the two-level utilitarian case falls prey to a compartmentalization problem and cannot uphold both respect and replaceability. What I call ‘humane lives’ are not appropriately valued by the lights of two-level utilitarianism itself.
Paramilitary Violence and Fascism: Imaginaries and Practices of Squadrismo, 1919–1925
Authors: Saluppo Alessandro
Published: January 2020

This article examines the violent imaginaries and practices of squadrismo in the period preceding the establishment of the Italian fascist dictatorship. Based on the examination of newly accessible documentary sources at provincial state archives, the article sheds light upon the ways in which squadristi imagined, performed, justified and ascribed meanings to their violent actions and the disintegrative impact of violence on local communities. The article concludes with a reflection on Blackshirt violence in the aftermath of the March on Rome and the persistence of the ideological and cultural fabric of squadrismo in the years of the dictatorship.
Comparing food desert residents with non-food desert residents on grocery shopping behaviours, diet and BMI: results from a propensity score analysis
Authors: Woodruff Rebecca C , Haardörfer Regine , Raskind Ilana G , Hermstad April , Kegler Michelle C
Published: January 2020

Objective:

To determine whether residence in a US Department of Agriculture-designated food desert is associated with perceived access to healthy foods, grocery shopping behaviours, diet and BMI among a national sample of primary food shoppers.

Design:

Data for the present study came from a self-administered cross-sectional survey administered in 2015. Residential addresses of respondents were geocoded to determine whether their census tract of residence was a designated food desert or not. Inverse probability of treatment-weighted regression was used to assess whether residence in a food desert was associated with dependent variables of interest.

Setting:

USA.

Participants:

Of 4942 adult survey respondents, residential addresses of 75·0 % (n 3705) primary food shoppers were included in the analysis.

Results:

Residence in a food desert (11·1 %, n 411) was not significantly associated with perceived access to healthy foods, most grocery shopping behaviours or dietary behaviour, but was significantly associated with primarily shopping at a superstore or supercentre v. a large grocery store (OR = 1·32; 95 % CI 1·02, 1·71; P = 0·03) and higher BMI (b = 1·14; 95 % CI 0·36, 1·93; P = 0·004).

Conclusions:

Results suggest that food desert residents shop at different food stores and have higher BMI than non-food desert residents.
Does food intake mediate the association between mindful eating and change in depressive symptoms?
Authors: Winkens LHH , Elstgeest LEM , van Strien T , Penninx BWJH , Visser M , Brouwer IA
Published: January 2020

Objective:

To examine mediation by (i) diet quality and (ii) diet quantity in the associations of mindful eating domains with 3-year change in depressive symptoms.

Design:

Depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale at baseline and 3-year follow-up. Four mindful eating domains (Focused Eating; Eating in response to Hunger and Satiety Cues; Eating with Awareness; Eating without Distraction) were measured with the Mindful Eating Behavior Scale. Food intake was measured with a 238-item FFQ. Diet quality was defined as the Mediterranean Diet Score (MDS). Diet quantity was defined as total energy intake (kcal/d; 1 kcal = 4·184 kJ). Mediation analyses with percentile-corrected bootstrap confidence intervals were conducted to calculate indirect effects.

Setting:

Longitudinal Aging Study Amsterdam.

Participants:

Adults aged 55 years or above (n 929).

Results:

Diet quality (MDS) did not mediate associations of any of the four mindful eating domains with change in depressive symptoms. In contrast, total energy intake did mediate the associations with change in depressive symptoms for the mindful eating domains Eating with Awareness (indirect effects fully adjusted models: B = −0·014, 95 % CI −0·037, −0·002) and Eating without Distraction (B = −0·013, 95 % CI −0·033, −0·001), but not for the other two domains. Post hoc multiple mediation analyses showed similar results.

Conclusions:

Higher scores on two mindful eating domains were associated with a decrease in depressive symptoms through lower total energy intake. Diet quantity, but not diet quality, could be a possible underlying mechanism in the associations between mindful eating and change in depressive symptoms.
Methods for Calibration of Specimen Temperature During In Situ Transmission Electron Microscopy Experiments
Authors: Gaulandris Fabrizio , Simonsen Søren B. , Wagner Jakob B. , Mølhave Kristian , Muto Shun , Kuhn Luise T.
Published: January 2020

One of the biggest challenges for in situ heating transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM) is the ability to measure the local temperature of the specimen accurately. Despite technological improvements in the construction of TEM/STEM heating holders, the problem of being able to measure the real sample temperature is still the subject of considerable discussion. In this study, we review the present literature on methodologies for temperature calibration. We analyze calibration methods that require the use of a thermometric material in addition to the specimen under study, as well as methods that can be performed directly on the specimen of interest without the need for a previous calibration. Finally, an overview of the most important characteristics of all the treated techniques, including temperature ranges and uncertainties, is provided in order to provide an accessory database to consult before an in situ TEM/STEM temperature calibration experiment.
Mapping palliative and end of care research in Australia (2000–2018)
Authors: Khalil H. , Downie A. , Ristevski E.
Published: January 2020

Objective

The objective of this study is to map the existent research undertaken in Australia into broad thematic areas and identify the characteristics of the studies and areas of future research in the literature.

Methods

A scoping review methodology was employed to map the current areas of research undertaken in Australia since January 2000 until the end of December 2018 according to years of publications, types of studies, populations studied, research themes, and areas of focus.

Results

Our review identified 1,405 Australian palliative care research publications between January 2000 and December 2018. Nearly 40% of the studies were quantitative (39%) and a third were qualitative studies (31%). The remainder of the studies were reviews, mixed methods, quality improvement projects, and others. One-third (30%) of the research was done with carers' participants followed by nurses (22%) and doctors and physicians (18%). The most frequently reported diagnosis in the studies was cancer with 42% of the publication total. The most frequently explored theme was physical symptoms (such as pain, breathlessness, nausea, delirium, and dyspnea) with a total of 16% of all articles followed by communication (15%). There was a large gap to the next most frequently explored theme with service delivery (9%) and coordination of care (8%). Assessment of patients (7%), end-of-life decision-making (6%), and rural/regional (6%) all produced a similar number of publications. Very few studies addressed topics such as quality of life, E-Health, after-hours care, spirituality, and health economics. Moreover, there were only 15 (1%) studies focused on the last days of life.

Significance of the results

The current review presented a comprehensive search of the literature across almost two decades in Australia in the palliative care setting. It has covered a breadth of research topics and highlighted urgent areas for further research.
Fragmentation of armed non-State actors in protracted armed conflicts: Some practical experiences on how to ensure compliance with humanitarian norms
Authors: Khadhraoui Hichem
Published: January 2020

For almost two decades now, Geneva Call has been engaged in developing humanitarian dialogue with some 150 armed non-State actors (ANSAs), with the aim of increasing their knowledge and respect of humanitarian norms. Developing a protection dialogue with ANSAs is not an easy task, and it becomes more complex when groups split, mutate or join larger movements. Humanitarian organizations need to adapt their analysis to a more frequent timescale, keeping in touch constantly with a wide range of key stakeholders in order not to lose track of the current groups’ status and structure. In this note, Geneva Call's Director of Operations discusses some of the organization's experiences and lessons learned.