bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on the Effects of Entrepreneurship and Internal and External CSR Activities on Hotel Employees’ Organizational Trust and Job Satisfaction
Authors:   The Tourism Sciences Society Of Korea, Ko Eun-Hee , Cho Minho
Published: January 2019

This study aimed to discover the effects of entrepreneurship and internal and external CSR activities on hotel employees' organizational trust and job satisfaction, comprehensively. A proposed model based on previous research was empirically tested via structural equation modeling by AMOS using 450 valid samples collected from current employees of 15 deluxe hotels in South Korea. The results showed that entrepreneurship had a direct impact on both internal and external CSR activities. Both CSR activities had a direct impact on organizational trust. Both CSR activities had no direct impact on job satisfaction, but job satisfaction was indirectly affected by both CSR activities through the full mediation of organizational trust. These findings indicate that there exist interrelationships among entrepreneurship, internal and external CSR activities, organizational trust, and job satisfaction. In particular, the importance of entrepreneurship and internal and external CSR activities were identified in terms of hotels' sustainable management and effective organizational management by confirming their impact on organizational trust of employees. In addition, organizational trust was verified as an antecedent factor to improve job satisfaction. Finally, theoretical contributions and practical implications of results are discussed.
CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p
Authors: Wang Yanjie , Zhang Junhua , Li Jian , Gui Rong , Nie Xinmin , Huang Rong
Published: January 2019

Hematopoietic stem cell transplantation is commonly used in patients with certain hematological or bone marrow tumors. Total body irradiation combined with chemotherapy is part of the preconditioning protocol that was the most commonly used before hematopoietic stem cell transplantation. However, total body irradiation preconditioning damages other normal cells in bone marrow. Therefore, exploring the mechanism of radiation resistance in bone marrow mesenchymal stem cells is of great significance for recovering the hematopoietic function after cell transplantation. This study aimed to demonstrate the miR-29b adsorption of circRNA_014511 and explore the effect of circRNA_014511 on radiosensitivity of bone marrow mesenchymal stem cells. In this study, circRNA_014511 overexpression vector was constructed and transfected into bone marrow mesenchymal stem cells, miR-29b-2-5p and P53 were found to be decreased, which could be reversed by miR29b-mimics. Dual luciferase reporter assay confirmed the binding of circRNA_014511 and mmu-miR-29b-2-5p. Flow cytometry analysis showed the apoptosis rate of bone marrow mesenchymal stem cells overexpressing circRNA_014511 was significantly decreased. In the circRNA_014511 transfection group, after cells were subjected to 6Gy irradiation, G2 phase arrest appeared, the expression of P21 and GADD45A was significantly decreased, and cyclin B1 was significantly increased. Colony formation assay showed the survival fraction of circRNA_014511 overexpression cells after irradiation was significantly higher than control group, and the radiosensitivity was decreased. In conclusion，our findings demonstrated that circRNA_014511 could inhibit the expression of P53 by binding miR-29b-2-5p, and decrease the radiosensitivity of bone marrow mesenchymal stem cells by affecting cell cycle and cell apoptosis.
Hyperbranchedpolymer-Rose Bengal (HBP-RB) preperation v1
Authors: Kim Il , Choi Changin
Published: January 2019

Carboxylic acid Rose Bengal (RB-C6-COOH), To create carobxylic acid Rose Bengal (RB-C6-COOH), Rose Bengal sodium salt (5 g, 4.91 mmol) and 8-bromohexanoic acid (2.87 g, 14.7 mmol) were dissolved in anhydrous Dimethylformamide (DMF, 10 mL) and refluxed at 80 °C for 8 h. The solvent was evaporated under reduced pressure. Diethyl ether 100 ml was added to the resulting residue, which was then stirred for 18 h at 25 °C. The solution was filtered to isolate the solid residue, dried, and then added to 100 ml distilled water and stirred for 18 h at 25 °C. It was then filtered, and the product was isolated as a red powder (yield = 0.68 g, 62.1%). Fig 1A shows the synthesis process. HBP-RB To obtain the HBP-RB compound, Hyperbranchedpolymer (HBP, Mn 5000 g/mol) (2 g, 0.4 mmol) was first dissolved in DMF, to which RB-C6-COOH (2.22 g, 2.0 mmol) was added and stirred for 30 min while cooling to 0 °C. EDC HCl (0.458 g, 2.4 mmol) and dimethylaminopyridine (0.012 g, 0.02 mmol) were added and stirred at 0 °C for 30 min. The reaction mixture was then warmed to room temperature and stirred for another 24 h. The solvent was removed under vacuum, dissolved in methanol, and purified by dialysis (molecular weight cutoff = 3.5 kDa) against methanol for 3 days and against Milli-Q® water for 2 days to remove unreacted RB-C6-COOH. Pure HBP-RB was obtained by lyophilization and was now ready for use (Fig 1B).
CD-19-directed immunotherapy resistance mechanisms of B-precursor acute lymphoblastic leukemia
Authors: Glukhanyuk E. V. , Stepanov A. V. , Popov A. M. , Maschan M. A.
Published: January 2019

Immunotherapy is the most rapidly evolving field in clinical malignant hematology. Targeting of the B-lineage surface antigen CD19 in B-lineage acute lymphoblastic leukemia and B-cell lymphoma is a story of great success. Recently two approaches of CD19 immunotargeting were approved for clinical application: CD3 × CD19 bi-specific T-cell engager blinatumomab and CD19 chimeric antigen receptor (CAR) Tcells. Both approaches demonstrated an unprecedented activity in a cohort of patients with relapsed and refractory B-cell leukemia and lymphoma both in the adult and pediatric population. Early clinical research has showed that tumors are able to escape the immunological control and become resistant to the immune attack. Mechanisms of the tumor immune escape are being actively studied and include diverse pathways, such as alternative splicing of CD19 and immunosuppressive tumor microenvironment. Current review briefly summarizes data regarding the mechanisms of CD19-positive leukemia resistance to CD19 immune targeting and discusses potential approaches to overcome it.
Exosomal proteases in colorectal cancer
Authors: Zambalova E. A. , Patysheva M. R. , Dimcha A. A. , Tamkovich S. N. , Grigor’eva A. E. , Kolegova E. S. , Kondakova I. V. , Afanas’ev S. G. , Yunusova N. V.
Published: January 2019

The objectiveis to evaluate the level of ADAM10 and ADAM17 (a disintegrin and metalloproteinase) proteases, as well as 20S-proteasomes in blood plasma exosomes of patients with colorectal cancer.

Materials and methods. The study included 60 patients with colorectal cancer (T2–4N0–2M0–1) and 10 control patients. The material for the study was EDTA blood plasma. Exosomes of blood plasma were isolated by ultrafiltration with ultracentrifugation. The level of tetraspanin-associated (ADAM10 and ADAM17) and tetraspanin-non-associated (20S-proteasome) proteases was evaluated by flow cytometry and Western blotting.

Results.A twice negative subpopulation (ADAM10–/ADAM17–) predominated in blood plasma exosomes of colorectal cancer patients and control patients. The level of ADAM10+/ADAM17– exosomes was significantly higher in the exosomes of the plasma of control patients. There were no significant differences between the ADAM10/ADAM17 subpopulations and the 20S-proteasome level, depending on sex, age and tumor grade. A decrease in the ADAM10+/ADAM17– subpopulation was found in patients with metastatic colorectal cancer with hematogenous metastases compared with patients with T2–4N1–2M0 and 20S-proteasome compared to T2–4N0M0. A decrease in ADAM10–/ ADAM17+ exosomes and 20S-proteasomes level was found in exosomes of patients with colorectal cancer with a metabolic syndrome  in comparison with patients without metabolic disorders.
Chemoresistance of PRAME-expressing melanoma cell can be resolved with help of bortezomib
Authors: Misyurin V. A. , Kalenichenko D. V. , Rudakova A. A. , Finashutina Yu. P. , Lyzhko N. A. , Tikhonova V. V. , Kesaeva L. A. , Solopova O. N. , Misyurina A. Е. , Velikanov A. N. , Baryshnikovа M. А. , Misyurin A. V.
Published: January 2019

Background.PRAME gene spontaneous expression is frequently observed in a cancer cell. The protein encoded by this gene increases  the viability of tumour cell. NF-κB signalling pathway takes part in PRAME upregulation. It proposes, that stress conditions may increase the expression level of PRAME in the tumour cell and increase cell’s viability after it. We hypothesized that this phenomenon determines chemoresistance of PRAME-expressing cell, which can be overcome by NF-κB inhibitors, such as bortezomib.

Materials and methods.We incubated A875 melanoma cells with cisplatin, bortezomib and dexamethasone, as well as with a mixture  of cisplatin with bortezomib and cisplatin with dexamethasone within 24 hours. To assess the cytotoxicity of these combinations MTT-test was used. For evaluation of PRAME expression level, real-time polymerase chain reaction was used. All data were analyzed with Wilcoxon test for coupled samples.

Results.It was found that cisplatin and dexamethasone increased an expression level of PRAME compared to control (p <0.03). The addition of dexamethasone to cisplatin reduced cytotoxic effect of cisplatin. Bortezomib has a cytotoxic effect, but it did not increase the activity  of PRAME gene (p = 0.12). PRAME gene activity in cells incubated with a mixture of cisplatin and bortezomib was observed at a lower level in comparison with cells incubated with cisplatin (p = 0.0277).

Conclusion.The results of experiments show that an increase of PRAME expression level reduces the sensitivity of melanoma cells to the cytotoxic effect of cisplatin. PRAME activity increases under stress conditions. Using of bortezomib can inhibit the growth of PRAME expression and makes the tumour cell more vulnerable to cytotoxic agents. On the other hand, dexamethasone may increase a resistance  of PRAME-expressing cell to cytotoxic effects.
Role of TRIM16 in cancers development
Authors: Spirina L. V. , Kondakova I. V. , Tarasenko N. V.
Published: January 2019

Тhe protein TRIM16 is involved in key intracellular processes, such as proliferation, cell differentiation and programmed death, including intrinsic and extrinsic apoptosis, autophagy-dependent cell death and immunogenic cell death. The TRIM16 protein acts the proteins TPD43, Gli-1, RARβ, Snail components and MAPK signaling pathway, cadherins, caspases and is also associated with the regulation  of the immune system via direct and indirect mechanisms. The influence of TRIM16 protein on the pathogenesis of hormone-dependent tumors is well-known. Further study of the TRIM16 role in the development and progression of malignant neoplasms will form the basis for  the development of new methods for predicting the course of the malignant process.
THE RESEARCH COMPETENCE OF YOUNGER GENERATION AS ONE OF THE MOST EFFECTIVE MEANS OF STUDYING THE ROLE OF UKRAINIANS IN THE ETHNO-CULTURAL PROCESSES OF THE WORLD
Authors: Boiko Svitlana
Published: January 2019

The article reveals the problem of competition between the countries according to intellectual indicators, emphasizes role of education and science in this competition, highlights the use of competence approach as a basis of a new educational paradigm, shows various theoretical options for disclosing the essence of the concepts of "proficiency", "competence", "research competence". The article highlights the importance of the research competence of the younger generation as an effective means of using scientific knowledge in the educational process for the purpose of popularizing Ukrainian studies as a science and discipline, preserving ethno-cultural traditions, studying the role of Ukrainians in the ethno-cultural processes of the world that affect the integrity of the ethnic group and the stability of the state. It was established that an important impetus to the development of research competence of young people is the International Contest on Ukrainian Studies for students of the 8th-11th forms of general education institutions conducted by the Research Institute of Ukrainian Studies of the Ministry of Education and Science of Ukraine. It is indicated that the main form of research competence implementation is the development of a research project that is quite effective in the process of transition from the traditional to the innovative paradigm of education.
"COMPANY OF MUTUAL AID OF PRIVATE CUSTOMERS" OF GALICIA: ANALYSIS OF THE STATUTE AND ACTIVITY
Authors: Berest Ihor
Published: January 2019

On the basis of trade union periodicals, the principle of historicism, scientific and objective approach, the article analyzes and shows the statute and activities of the trade union of private servants of Eastern Galicia. The present state and development of the historiography of the problems, the history of the trade union movement was investigated, it was proved that the main event in the trade union movement of the middle of the ХІХ century became social processes in Eastern Galicia, which created a new working-class movement on the material and moral protection of workers. The study of this problem has an important scientific significance, since it enables to show the work of the first professional union of private employees, to analyze their program document and to show the evolution of trade union movement until the adoption of the Constitution of 1867. Among the works devoted to this topic, unfortunately, there are no monographs or scientific researches by Ukrainian scholars, therefore, in the article we rely on the study of Polish scholars: Bali Stanislav, Kishchinsky Lucian, and trade union periodicals, where there is an attempt to present the history of trade union movement in a new course of events. Thus, we can conclude that the Society for the Mutual Assistance of Private Servants was formed, the founding of which was sought or projected by employees from 1846. And, despite for political blockages, or attacks by employers and many other reasons, the suspension of the creation of a basic document, however, achieved the goal of 1867 - the Society began its activities.
POCHAYIV'S PUBLISHING CENTER AS FACTOR OF CONSOLIDATION OF UKRAINIAN PEOPLE OF THE XVIII - BEGINNING OF THE XIX CENTURY
Authors: Bochkovskaya Valentina
Published: January 2019

Pochaivska Lavra was one of the largest cultural centers in the XVIII - the first third of the XIX century. Pochaivs’ka Lavra Printing house, after the printing house of the Kyiv-Pechers’k Monastery, was one of most powerful publishing center in the Ukrainian lands. Until the end of the XVIII century it published about 250 editions in Cyrillic and about 200 editions in Latin and others languages. At present, relevant is unbiased and objective coverage of all aspects of the activity of the Pochayivs’ka Lavra at the period of the Basilians as the least studied and on the other hand as the most productive period, especially in the book publishing process. The purpose of this article is an attempt to determine the role of the Pochayiv monastery as the center of the unification of Ukrainians, analyzing the repertoire of the Pochayiv publishing house at the 18th and the beginning of the 19th century, the language of publications, their design and contacts with other publishing houses. It is concluded that the most productive activity of the Pochayiv printing house was Uniate period - XVIII - beginning of the XIX century. The typical features of the printing industry of this time were: a diverse repertoire of books that included the spiritual and secular literature of various Christian confessions, original and translated works of religious moralistic content, multilingual editions, and their high artistic level. The activity of the Pochayiv Assumption printing house extending beyond narrow confessional boundaries. Like the Kyiv editions were used not only by the Orthodox, but also by the Catholics of the Byzantine rite, the Pochaiv books and engravings spread among the Orthodox population of Ukraine. The undoubted merit of this cultural and spiritual center was that it continued the tradition of printing Ukrainian-language publications in conditions where the Kyiv- Pechers’ka printing house was deprived of such a possibility under the pressure of decrees of Russian secular and church authorities. The Pochayiv printing house maintained close contacts with other publishing centers - both Uniate and Orthodox. This is evidenced by the active using and reprint of their publications in Pochaiv. Despite the different denominations, there were close contacts between the Pochayiv Uniate and Kyiv-Pechers’k Orthodox printing houses. This testified to the spiritual unity of Ukrainian lands besides state borders, religious and administrative barriers of secular and church authorities.
Comunicación en las federaciones deportivas en Portugal: ¿dónde estamos?
Authors: Eiró-Gomes Mafalda , Nunes Tatiana
Published: January 2019

Lo que buscamos en este artículo es entender cómo conceptualizan las Federaciones Deportivas en Portugal las RRPP (la comunicación) en toda la amplitud de esta disciplina de la comunicación aplicada. ¿Cómo es encarada la comunicación estratégica en las federaciones deportivas em Portugal? Se ha recurrido al método de encuesta para recoger los datos y al análisis de contenido con recurso al programa N-Vivo para una su comprensión.
Reseña del libro: cómo hacer un plan estratégico de comunicación. Vol. II: públicos y stakeholders
Authors: Espinosa Silvia
Published: January 2019

Reseña de libro: Cómo hacer un plan estratégico de comunicación. Vol. II: Públicos y stakeholders
NOVOS ACHADOS DE MAMÍFEROS PLEISTOCÊNICOS EM IRAUÇUBA, CEARÁ, NORDESTE, BRASIL
Authors: Cardoso Gina , Viana Maria Somália Sales , Oliveira Juliana Pereira , Abreu Dayanne , Chaves Arquimedes Pompeu de Paulo , Araujo Cleber Henrique de Souza
Published: January 2019

Restos de megafauna são muito comuns em depósitos de idade Pleistocênica no Nordeste brasileiro. Para o Ceará, essas ocorrências são registradas para quase todo o estado, incluindo recentes achados no Município de Irauçuba, cujos novos dados taxonômicos de espécimes coletados no distrito de Juá, revelaram a presença de: Eremotherium laurillardi, Glossotherium, Glyptotherium cf. G. cylindricum, Panochthus, Xenorhinotherium baihense, Equus, Toxodontidae e Proboscidea, este último, já descrito anteriormente. Cerca de 300 fragmentos de ossos foram analisados, sendo na maioria material de pós-crânio dos mamíferos gigantes herbívoros. Como o local ainda não foi escavado e devido ao potencial paleontológico apresentado, sugere-se estudo posterior com a exumação do depósito.
Biochemical indices and radiological examination to evaluate bone health in children with β-thalassemia major
Authors: P. K. Madhu , B. Bhagwan
Published: January 2019

Background: β-Thalassemia major is a serious hematological problem requiring regular blood transfusions. In regularly transfused thalassemic patients, metabolic bone disease is an important cause of morbidity. Problems include bone pain, deformities, short stature, osteopenia/osteoporosis, rickets, osteomalacia, spinal deformities, nerve compression and fractures. This study was undertaken to evaluate the status of bone health in children with β-thalassemia major by selected biochemical indices and radiological examination.Methods: Fifty children with β- thalassemia major were enrolled. Detailed history, examination and anthropometry were done. Serum calcium, phosphorus, magnesium, alkaline phosphatase, and vitamin D levels were measured. X-ray of skull, wrist, and knee were studied for radiological changes. Biochemical indices were analysed with appropriate statistical tests.Results: Stunting and wasting was observed in 58% and 44% children respectively. Hypocalcaemia was seen in 22%, hyperphosphatemia in 56% and 24% children had raised alkaline phosphatase levels. Vitamin D levels were severely deficient in 12%, deficient in 50%, and insufficient in 38% of children. There was no significant difference between vitamin D levels of cases and controls. Radiologically almost all children had a range of osteopathy, like thinned out cortex (96%), medullary expansion (54%), loss of density (40%), diffuse osteoporosis (18%) and growth arrest lines were seen in 8% children.Conclusions: Vitamin D abnormalities and radiological features suggestive of decreased bone mineralization are seen in all the children with β-thalassemia major treated with periodic blood transfusion at this institute. No biochemical predictors of bone disease in these children were identified.
A cross sectional study to assess the knowledge and response to dog bite among the urban and rural population of Hubballi taluk
Authors: Godbole Maneesha , Joshi Anjana Ramachandra , Bant Dattatraya D.
Published: January 2019

Background: Rabies is a fatal zoonotic disease of the central nervous system, most commonly caused by the bite of rabid dogs. Globally canine rabies causes 59,000 human deaths, over 3.7 million DALYs and 8.6 billion USD economic losses annually. These losses are due to a lack of knowledge about wound management and post-exposure prophylaxis. The objective of the study was to assess the knowledge and practices following dog bite and its management among the urban and rural population.Methods: A cross-sectional study was conducted in the field practice area of KIMS, Hubli. 120 households of the urban and rural locality were interviewed with a semi-structured pretested questionnaire.Results: Overall 89.16% of the study population was aware that the disease can be prevented by vaccination. 35% of the rural and 28% of the urban population believed that the disease can spread from person to person. The knowledge about the site and the number of doses of vaccine was poor among both the population. The harmful practices for treatment of bite were still prevalent among both rural (25%) and urban (8.3%) population.Conclusions: The knowledge about the dog bite management and Rabies prevention is insufficient among both populations. There are myths and misconceptions about the disease and wound management. Practices like application of harmful substances like lime, turmeric, mud are the problems hindering rabies prevention and control. Proper steps need to be taken up to control the canine rabies.
A MÚSICA SACRA INDÍGENA TERENA – DIFERENTES OLHARES SOBRE O REPERTÓRIO DO CORO LU-TERENA
Authors: Blum Schneider Isabel Cristina , Albernaz do Nascimento Guimarães Fernanda
Published: January 2019

Esta pesquisa demonstra parte do repertório entoado pelo coro Lu-Terena - um coro de aldeados indígenas Terena que habita a aldeia Aldeinha, Anastácio, Mato Grosso do Sul. O coro entoa hinos e salmos em sua língua nativa pertencente ao grupo sociolinguístico Aruák, inseridos na Missa Luterana da região. O objetivo: elucidar as sonoridades vigentes na música sacra indígena Terena, demonstrando como são feitos os escambos culturais entre os luteranos e os Terena. A metodologia qualitativa, demonstra procedimentos embasados na pesquisa in loco e bibliográfica. O resultado indica que foi preciso recorrer a diferentes olhares para abarcar as sonoridades: a estrutura Macro e Micro de Figueiredo; Pucci e as sonoridades indígenas; o sistema teórico Kamayurá de Bastos; a retórica e as ideias musicais de Piedade; e os gêneros do discurso de Bakhtin. Percebeu-se que nem todos os olhares contemplaram as sonoridades, demonstrando a necessidade da continuidade pela busca de olhares complementares.
Noticias relativas a la música y los músicos, procedentes de las Actas Capitulares de la iglesia de Santa María del Pilar de Zaragoza, 1600-1656
Authors: Ezquerro Esteban Antonio
Published: January 2019

Las noticias musicales de la primera mitad del siglo XVII procedentes de las actas capitulares de la hoy catedral basílica de Nuestra Señora del Pilar de Zaragoza, eran inéditas hasta ahora. La aparición, el 20.05.2004 del volumen de actas correspondiente a los años 1614-1656, no disponible para la investigación hasta dicha fecha, ha motivado el interés musicológico por recuperar noticia de las actividades musicales y de los músicos que protagonizaron aquel período del Siglo de Oro de las artes y las letras hispano, en el que la corte habsbúrgica visitara la capital aragonesa en diversas ocasiones, contribuyendo, de ese modo, a un incremento popular de la devoción hacia dicho templo y su significación. Un ascenso de la devoción popular  que, a partir de la tradición legendaria de la aparición de María al apóstol Santiago (en el año 40 de nuestra Era, encaramada a un pilar a orillas del río Ebro), había convertido al templo mariano zaragozano en un notable centro de peregrinación, a lo que se uniría el denominado “milagro de Calanda”, la declaración de Santa María del Pilar como patrona primero de la ciudad de Zaragoza y enseguida del Reino de Aragón, y que iba a desembocar, ya el 11.02.1676 en la bula del papa Clemente X  In apostolicae dignitatis. En virtud de esta última, los cabildos zaragozanos de la iglesia metropolitana del Salvador (vulgo “La Seo”) y el de Santa María de El Pilar, se unían definitivamente bajo la autoridad de un único arzobispo de Zaragoza, alcanzando, de ese modo, el templo de Santa María el rango de catedral. En consecuencia, en esta documentación aparecen mencionados nombres de maestros de capilla, organistas y otros músicos, a la que se añaden ahora también los correspondientes a los años 1600-1613, estableciendo así, documentalmente, la nómina de protagonistas músicos de la iglesia y su fijación cronológica.
Acerca de la recuperación de Venus y Adonis, de José de Nebra
Authors: González Marín Luis Antonio
Published: January 2019

El artículo relata el proceso de recuperación de una ópera inédita de José de Nebra, Venus y Adonis (Madrid, 1729), desde la investigación documental en archivos y el estudio crítico de fuentes hasta la preparación de una edición crítica para el estudio y una edición práctica destinada a la interpretación. El proceso concluye con la interpretación, en salas de conciertos, de la obra y su grabación y transmisión por diversos medios. El artículo incluye una reflexión sobre los criterios y límites de la recuperación de patrimonio musical histórico.
La música valenciana en la pimera mitad del siglo XX: necesidad de una nueva contextualización en la música española de su tiempo
Authors: Hernández Farinós J. Pascual
Published: January 2019

La música española del siglo XX ha sido narrada siguiendo unas pautas historiográficas que, pese a su aceptación general, plantean dificultades para incluir toda la complejidad cultural y artística de este periodo, desvelada por recientes investigaciones musicológicas. Estas dificultades son también aplicables a la música valenciana de aquel siglo XX, por lo que este texto intenta plantear alternativas a esta narración, fruto de la experiencia del propio autor al manejar fuentes bibliográficas en la elaboración de su Tesis Doctoral.
Control of Ni/Ce1-xMxOy Catalyst Properties Via the Selection of Dopant M = Gd, La, Mg. Part 1. Physicochemical Characteristics
Authors: Kerzhentsev M.A. , Matus E.V. , Ismagilov I.Z. , Sukhova O.B. , Bharali P. , Ismagilov Z.R.
Published: January 2019

To develop effective reforming catalyst a series of Ni catalysts (Ni content 2‒15 wt.%) supported on ceria-based oxides Ce1-xMxOy were synthesized by incipient wetness impregnation. To regulate dispersion and reducibility of the active component, the variation of chemical composition of support was performed. The prepared samples of supports and catalysts were characterized by X-ray spectral fluorescence analysis, N2 adsorption/desorption, X-ray diffraction, transmission electron microscopy, and thermal analysis. It was found that the support composition specified the forms of stabilization (NiO or Ni-M-O oxides, M = La, Mg) and capability to reduction of Ni-component through the realization of a different extent of interaction between Ni-containing species and support. The increase of M content in CexM1-xOy support induces the decrease of CexM1-xOy crystallite size, improvement of Ni active component dispersion and the increase of hard-to-reduce portion of nickel cations due to the growth in the degree of nickel- CexM1-xOy interaction. The identified variation of the textural, structural and redox characteristics of the Ni/CexM1-xOy catalysts should influence their performance in the catalytic process.
ATENÇÃO À SAÚDE DE LÉSBICAS, GAYS, BISSEXUAIS, TRAVESTIS E TRANSEXUAIS NA ESTRATÉGIA SAÚDE DA FAMÍLIA
Authors: Belém Jameson Moreira , Alves Maria Juscinaide Henrique , Pereira Emanuelly Vieira , Moreira Felice Teles Lira dos Santos , Quirino Glauberto Da Silva , Albuquerque Grayce Alencar
Published: January 2019

Objetivo: analisar a atenção à saúde prestada à população de Lésbicas, Gays, Bissexuais, Travestis e Transexuais na Estratégia Saúde da Família. Método: estudo qualitativo desenvolvido em junho de 2014 com 12 enfermeiros, no interior do Ceará, Brasil, por meio de entrevista semiestruturada. Os dados foram organizados e analisados com base na análise categorial temática e eixos estratégicos da política nacional de saúde integral. Resultados: as ações de promoção e vigilância da saúde eram reducionistas, fragmentadas, enviesadas em função da orientação sexual e afetadas pela baixa assiduidade, estereótipos e barreiras nos atendimentos. Esse contexto era agravado por lacunas na formação acadêmica, qualificação dos profissionais sobre sexualidade e dificuldade de implementação, monitoramento e avaliação da política de saúde. Conclusão: a atenção à saúde prestada à população de Lésbicas, Gays, Bissexuais, Travestis e Transexuais na Estratégia Saúde da Família exige mudanças paradigmáticas desde o âmbito teórico-organizacional às relações de cuidado.

Descritores: Minorias Sexuais. Assistência Integral à Saúde. Desigualdades em Saúde. Enfermagem de Atenção Primária. Atenção Primária à Saúde.
Morphofunctional Characteristics of the Stomach Exposed to Sodium Tetraborate
Authors: Berdalinova A. K. , Umbetov T. Zh. , Shevlyuk N. N. , Zhurabekova G. A.
Published: January 2019

The aim is to study the morphological and functional characteristics of the gastric mucosa of rats exposed to sodium tetraborate.

Material and methods. The object of the study were the stomachs of 50 white male mongrel rats. The animals were divided into 2 groups. Animals of the 1st group once intragastrically through the probe entered the borax in the dose of LD50– 5000 mg/kg. Animals of the second group intragastrically through a tube daily introduced sodium tetraborate at a dose of 1/10 LD50– 500 mg/kg. the Animals of the 1stgroup were withdrawn from the experiment in a day after single administration of sodium tetraborate, animals of the 2ndgroup – 7, 14, 21 and 30 days after the start of the experiment. The obtained material was treated using histological, histochemical and immunocytochemical methods.

Results. With a single and long-term exposure to sodium tetraborate in the gastric mucosa against the background of edema, stagnation of blood elements in the blood vessels of the microcirculatory bed, moderate leukocyte infiltration, there was focal desquamation of the epithelium, numerous destructive changes in the cover and glandular cells of the gastric mucosa, a significant death of epithelial cells, accompanied by a decrease in the secretory function of mucous cells. Destructive changes are more pronounced at a higher dose of sodium tetraborate. Damage to epithelial cells lead to an increase in the zone of proliferative activity of the epithelium of the mucous membrane (mitoses are noted not only in the neck of the gland, but also in the body of the gland and in the epithelium of gastric pits). In the own plate of the mucous membrane there is an increase in the activity of fibroblasts.

Conclusion. The data obtained indicate a negative impact of the used doses of sodium tetraborate. The expansion of the zone of proliferative activity of the epithelium of the mucous membrane of the stomach, aimed at the restoration of structural homeostasis, is not fully offset with a significant destruction of epithelial and glandular cells. The increase in the activity of fibroblastic differon cells indicates their greater resistance to the negative effects of sodium tetraborate in comparison with epithelial cells.
Structure Features and Sensitivity of Hippocampal Cells to the Endothelial Vascular Growth Factor Against the Background of Intranasal Administration of Titanium Dioxide Nanoparticles
Authors: Sharafutdinova L. A. , Valiullin V. V.
Published: January 2019

The aim:to study the structural characteristics and sensitivity of rat hippocampal cells to the endothelial growth factor of vessels against intranasal administration of nanoparticles (NP) TiO2(rutile form, 40–60 nm, daily, 10 mg/kg animal body weight, 30 days).

Material and methods.When studying the effect of the studied NP on the morphological characteristics of the hippocampus, animals of the experimental group were intranasally injected daily with a suspension of NP TiO2(10 mg/kg body weight, 30 days), and the rats of the control group received distilled water in the same volume. Animals were removed from the experiment after 30 days of overdose of diethyl ether and the brain was removed for histological and electron microscopic examination. We used classical morphological approaches, electron microscopy and immunohistochemical staining with antibodies to the cell sensitivity marker, the receptor for endothelial vascular growth factor VEGFR-1 / Flt-1.The classical morphological approaches, the method of electron microscopy and immunohistochemical staining with antibodies to the marker of sensitivity of the receptor cells to the endothelial vascular growth factor VEGFR-1/Flt-1 were used.

Results. It has been established that against the background of intranasal administration of NP TiO2in the pyramidal layer of CA1and CA3hippocampal fields, the density of neuronal packing decreases, the area of the nucleus and the pericarion of the cells decrease in comparison with the control. Ultrastructural changes were detected, indicating a damage to the structures of the energy and protein synthesis apparatus of neurons. Immunohistochemical study revealed an increase in the sensitivity of vascular endothelial cells and the hippocampal macroglia of the experimental group of animals to the endothelial factor of vascular growth.

Conclusions. Intranasal management of NP TiO2leads to negative changes in the structural characteristics of the CA1, CA3hippocampal zones, ultramicroscopic features, and also to an increase in the sensitivity of a number of cells to VEGF, which indicates their possible neurotoxic effect.
Hepcidin and HFE Polymorphisms and Ferritin Level in β-Thalassemia Major
Authors: Fekri Kiavash , Asle Rasouli Negar , Tavallai Zavareh Seyyed Abdolhossein , Jalil Milad , Moradi Fahimeh , Hosseinpour Maryam , Teimori Hossein
Published: January 2019

Background: Thalassemia patients need repeated transfusion that lead to increased blood ferritin level and iron overload in the heart and liver. Because the roles of hepcidin antimicrobial peptide (HAMP) and hemocromatosis protein (HFE) in iron metabolism have been confirmed, this study investigated the effects of these gene's polymorphisms on blood ferritin levels and iron overload in the heart and liver in patients with beta thalassemia major
Materials and Methods: This cross-sectional study was conducted on 91 patients referring to the Hajar Hospital in Shahrekord, Iran in 2015. After the blood samples were collected, the ferritin levels were measured, DNA was extracted from the blood cells, and the types of polymorphisms were determined using PCR-RFLP. Data of MRI T2* in the heart and liver were drawn from the patients' medical files. Data analysis was conducted by t-test, chi-square test, Fisher's exact test, and Pearson correlation coefficient.
Results: There was no significant correlation between blood ferritin level and c.-582 A>G polymorphisms of hepcidin gene (p=0.58), and H63D of HFE gene (p=0.818). In addition, there was no significant association between the polymorphisms and heart and liver MRI, but there was a significant association between blood ferritin level and qualitative heart and liver MRI (r=-0.34, p=0.035 and r=-0.001, p=0.609, respectively).
Conclusion: In patients with β-thalassemia major, the presence of c.-582A>G HAMP and H63D HFE polymorphisms is not effective on blood ferritin level and iron overload in the heart and liver in the studied region.
Komunikacyjna analiza tekstu perswazyjnego
Authors: Habrajska Grażyna
Published: January 2019

W artykule przestawione zostały analizy przykładów tekstów perswazyjnych realizowanych w różnych kodach. Sposób analizy tych tekstów, niezależnie od zastosowanego kodu, jest taki sam. Zarówno w przypadku tekstów werbalnych, jak i wizualnych czy wizualno-werbalnych, jeśli mają wpływać na postawy lub zachowania odbiorców, konieczne są wykorzystanie wiedzy dyskursywnej i umiejętność standaryzacji argumentów, które trzeba wyodrębnić z tekstu. Wiedza dyskursywna niezbędna jest do interpretacji i zrozumienia komunikatu. Umożliwia ona przywołanie tła ogólnego i sytuacji konkretnej – czyli określenie sytuacji komunikacyjnej, w jakiej osadzona jest każda perswazja. Wskazuje także na obszar, do którego nawiązują reguły ogólne, stanowiące pierwszą przesłankę w argumentacji aksjologicznej. Natomiast standaryzacja argumentów pozwala na sprecyzowanie celu perswazyjnego.
Pendidikan Berbasis Stake Holders Teori dan Implikasinya pada Manajemen Perguruan Tinggi
Authors: Mu'ammaroh Nurul Lail Rosyidatul
Published: January 2019

Universities are still in the process of transitioning to the global level; therefore universities require autonomy, accountability, legitimacy, and credibility. The backwardness of the education sector must be pursued by improving the education system, and higher education as an organization must be able to adapt to these changes so as not to suffer from increasingly fierce competition. One significant effort is to reform education through innovation and creativity. Consequently, the above needs and the objectives of implementing higher education, it requires that the management of higher education institutions be carried out professionally. This can be realized when the college has an excellent strategic management plan because with proper planning the organization will be able to walk towards achieving its goals and sustainability, as well as the function of the institution as a protected educational institution. The implementation of higher education based on stakeholders inevitably must have a plan for a sustainable organizational and educational activity strategy, in accordance with the conditions of the internal environment and the external environment (competition with similar universities, regulators, inflation/ economic conditions, etc.) so that universities always have excellence competitiveness, added value and differentiation to satisfy stakeholders, which in turn make the acceptance of higher education continuously exist, respected and needed by the community.
MENYOAL PROFESIONALISME GURU PROFESIONAL: SEBUAH TELAAH KRITIS
Authors: Almu'tasim Amru
Published: January 2019

Teacher is a designation for the position, position and profession for someone who devoted himself in the field of education through educational interaction patterned, formal, and systematic (Surya, 1998). Historically professorship connote uplifted services (noblest vocation). They named the child paedagogos or waiters, waitresses humanizing honorable man, or man of human beings (gogos humanities). Guru is one of the human component in the teaching-learning process, which had a role in the formation of human resources business potential in development. Therefore, teachers must be someone who can 'digugu' and 'imitated'. Teachers must participate actively and putting his position as professionals, in accordance with the demands of the growing community.

 

Keywords: professionalism, professional teacher
KAJIAN TEMATIS Al-QUR’AN DAN HADITS TENTANG KEPEMIMPINAN
Authors: Pramitha Devi
Published: January 2019

Leaders and leadership are two interrelated problems of daily life in society, organization, nation and state. The development level of society, organizations and nations and countries influenced by the leaders and leadership. Islam itself as a religion rahmatan lil 'Alamin also put the issue of leaders and leadership as one of the major issues in his teaching. In the Qur'an and Hadith leadership gets a share of the discussion is not small, many verses of the Koran and the hadiths of the Prophet who Membincang about leadership. In the Islamic concept itself, leadership can be defined as a concept of interaction, relationships, processes of authority, influence activities, directs and coordinates both horizontally and vertically.

 

Keywords: leadership, al-Qur’an, hadith
PENINGKATAN MUTU SKL SISWA SMK MELALUI MODEL YANG BERORIENTASI PADA KEMAMPUAN PERANCANGAN DAN MELAKUKAN EKSPERIMEN UNTUK MELATIH KETRAMPILAN BERPIKIR KRITIS
Authors: Maimunah Siti Annijat
Published: January 2019

The legislation System of national education No. 20 Year 2003 about education standards consist of standard content, processes, the competence of graduates, educational personnel, infrastructure, management, financing and assessment of education.

Standards of competence and standard of graduates, Graduates in Vocational secondary schools are expected to have the ability to build Standard and competence of graduates of the creative, and innovatively in decision making. The reality of the situation of vocational high school graduates do not meet the standard of competence of Graduates, because the existence of limited practical tools so that the experiment also rarely do.

The purpose of the study is to describe the practicality, and the effectiveness of the implementation of the model of learning ability-oriented design and conduct experiments to practice critical thinking skills of students of SMK.

As for the approach of this study is a descriptive qualitative. Based on the results of the implementation of the developed learning the real device, it can be concluded that the ability of the design-oriented learning and experimentation to train creative and critical thinking skills a valid, practical, effective, and can enhance critical thinking skills and creative as well as achieving perfection results of student learning. Positive student response after follow learning by applying the learning ability-oriented device design and perform experiments to practice critical thinking skills and creative students.

 

Key words: quality improvement of the standard of competence of graduates of vocational high school Students, the ability of Designing and performing experiments, Thinking Skills
METAMORFOSIS INSTITUSI PENDIDIKAN ISLAM DI INDONESIA
Authors: Abubakar Isti’anah
Published: January 2019

The study of the history of Islamic education in Indonesia is a study that should continue to be able to give ibrah for development and improvement of the quality of education. This dynamics is the metamorphosis, a process towards perfection. Based on a historical perspective, Islamic educational institution found that Indonesia is still experiencing a metamorphosis is less perfect. This indicates that the Islamic educational institutions should hold first settled towards perfect metamorphosis, a process that ushers in the institution of Islamic institutions on excellence and advancement. This paper attempts, identify the metamorphosis of the Islamic educational institutions as well as find aspects of the imperfections of the process metamorfosisnya. The results of this paper will, be insightful while discourse and early action to improve the image and quality of the institutions of Islam.
L’Uomo Nuovo: Sport e corporativismo tra fascismo e cattolicesimo italiano nell’Estado Novo portoghese tra le due guerre = El Hombre Nuevo. Deporte y corporativismo entre el fascismo y el catolicismo italiano en el Estado Novo Portugués entre las dos guerras = The New Man Sport and corporatism between fascism and Italian Catholicism in the Portuguese Novo State between the two wars
Authors: Serapiglia Daniele
Published: January 2019

Resumen: Entre las dos guerras, Mihail Manoilsecu calificó al siglo XX como "el siglo del corporativismo". Desde hace algunos años, los historiadores están desarrollando el estudio de la dimensión transnacional del corporativismo, enfocándose especialmente en su impacto en las políticas sociales de distintos regímenes autoritarios. Hasta ahora los casos más analizados han sido Italia y Portugal, puesto que fueron los países donde el intento de aplicar las políticas corporativas fue más duradero. El intérprete de la sociedad corporativa tenía que ser el “hombre nuevo”, para cuya formación espiritual la educación deportiva era esencial. Este artículo se centra en la educación deportiva y pretende demostrar cómo el deporte también fue un ingrediente clave de la retórica corporativa entre las dos guerras.Palabras clave: Deporte, corporativismo, totalitarismo, educación, fascismo.Abstract: Between the two wars, Mihail Manoilsecu defined the 20th century as "the century of corporatism". In recent years, scholars have been focusing on the transnational dimension of corporatism, studying its doctrine and its effects on the social policies of different authoritarian regimes. So far, the most studied countries have been Italy and Portugal, the countries where the attempt to apply corporatist policies was most long-lasting. The interpreter of this corporatist society had to be the “new man”: sport was essential for his spiritual training. This article is based on sport education and it aims to demonstrate how sport was framed within the rhetoric of corporatism between the two wars.Keywords: Sport, corporatism, totalitarianism, education, fascism.
Gutmaro Gómez Bravo, Geografía humana de la represión franquista. Del golpe a la guerra de ocupación (1936-1941), Madrid, Cátedra. 2017, 311 páginas
Authors: Chaves Palacios Julián
Published: January 2019

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Effects of liquid ionic silver concentration on caspase-3 and p53mt expressions in the oral mucosal epithelium of Wistar rats
Authors: Muharram R. Aries , Istiati I. , Soesilawati Pratiwi
Published: January 2019

Background: Silver, especially oxidized silver, has been used as a medicine considered to have bactericidal properties. In the present day, ionic silver (Ag+) is also used in the manufacture of cosmetics, socks, food containers, detergents, sprays and other products to prevent the spread of germs. Unfortunately, ionic silver is assumed to be toxic not only to bacteria, but also to humans and the environment. Therefore, it is essential to identify the optimum dosage of ionic silver considered safe by investigating the effects of ionic silver concentration on cell death through activation of mutant p-53 expression by caspase 3 in the oral epithelium. Purpose: This research aimed to analyze the effects of concentrated liquid ionic silver (Ag+) on caspase-3 and mutant p53 expression in the oral mucosal epithelium. Methods: This research constituted a laboratory-based experimental study with posttest-only design. The research subjects consisted of 28 Wistar rats, divided into four treatment groups, namely; KK (with Aquadest), KP 1 (with 5% liquid ionic silver), KP 2 (with 10% liquid ionic silver) and KP 3 (with 15% liquid ionic silver). Each rat was then treated orally with 0.5ml of liquid ionic silver at fixed concentrations twice a day for seven days. The Wistar rats were then terminated and their tissue samples processed by means of histopathological and immunohistochemical staining examination. The monoclonal Caspase-3 and mutant p53 expressions in each group were evaluated with the data being tabulated and analyzed statistically. Results: Mutant p53 expression was also found in the control group. Moreover, the higher the concentration of liquid ionic silver, the greater the elevated Caspase-3 and mutant p53 expressions. Conclusion:  The concentration of liquid ionic silver plays an important role in elevating Caspase-3 and mutant p53 expressions.