bluuebunny/crossref_metadata_2025 huggingface dataset:
The State of development: a new form for a new content
Authors:   Moscow State Budgetary Institution Moscow Analytical Center in the field of urban economy, Filippov A.P. , Filippov D.A. ,   Moscow State Budgetary Institution Moscow Analytical Center in the field of urban economy
Published: June 2023

The article proposes and substantiates a new form of vertically integrated state and municipal government, including, first of all, a sufficiently developed system of local self-government. This form of state management is considered by the authors as the most adequate for a mixed, socially-oriented, state-corporate model of the Russian economy, defined by them as a "development state".
LARGEST CITIES – REGIONAL CENTERS OF INNOVATIVE DEVELOPMENT
Authors:   Project Support Fund National Technological initiatives, Medvedev V.V. , Shevchenko I.K. ,   Southern Federal University, Razvadovskaya Yu.V. ,   Institute of Management in Economic Ecological and Social Systems Southern Federal university
Published: June 2023

The article examines the existing approaches to the definition of the largest cities as regional centers of innovative and scientific development of territories. A study of foreign and domestic experience in the implementation of industrial changes based on spatial agglomeration was conducted, the main models of the implementation of industrial changes were identified, the largest cities – regional innovation centers at various stages of the development of the domestic economy (1989, 2019, 2021) were identified based on the analysis of the patent landscape. The authors formulate a conclusion about the decisive role of the largest cities as points of innovative, scientific and cultural growth in the evolutionary development of territorial production systems.
Importance of Change control in Pharmaceutical Industry: A Review
Authors: Chowdhary Yogita , kumar Babita
Published: June 2023

Change Control is the process that management uses to identify, document and authorize changes to an IT environment. It minimizes the likelihood of disruptions, unauthorized alterations and errors. The change control procedures should be designed with the size and complexity of the environment in mind. Change control is used to ensure changes to a product or system are introduced in a controlled and coordinated manner. It reduces the possibility that unnecessary changes will be introduced to a system without forethought, introducing faults into the system or undoing changes made by other users of software. The goals of a change control procedure usually include minimal disruption to services, reduction in back-out activities, and cost-effective utilization of resources involved in implementing change. Change control is used in various industries, including in IT, software development, the pharmaceutical industry, the medical device industry, and other engineering/manufacturing industries. For the IT and software industries, change control is a major aspect of the broader discipline of change management. There are two types of changes 1. Disruptive change 2. Dynamic change. is a non-localized future irreversible and change that affects a portion of an industry. This can be caused by changes in market trends causing a shift in the mode of production to fit the customer demands. Dynamic Change is multi-dimensional change that is predictable on a measurable scale. Change control is a CGMP concept that focuses on managing change to prevent unintended consequences. Manufacturing changes (i.e changes that alter specifications, a critical product attribute or bioavailability) require regulatory filings and prior regulatory approval.
Presenting a surface of revolution by using orthonormal projection with the TikZ package
Authors: Tran Le Nam , Phan Thi Hiep
Published: June 2023

Orthonormal projections emerge from subjecting 3-dimensional vectors to orthogonal transformations and projecting them to 2 dimensions. They are not to be confused with the perspective projections, which are more realistic. Orthonormal projections may be thought of a limit of perspective projections at large distances, where large means that the distance of the observer is much larger than the dimensions of the objects that get depicted. The paper will calculate the critical points of light on revolution surfaces. After that, the TikZ library in the LaTeX compiler is used to represent cylinders, cones, and their curves accurately. Thereby, readers can draw most of the figures representing the revolutions in Mathematical subject, at the high school level.
Hydrogen Permeability of Tectosilicate Glasses for Tank Barrier Liners
Authors: Reinsch Stefan , Welter Thorben , Müller Ralf , Deubener Joachim
Published: June 2023

The permeation of hydrogen gas was studied in meta-aluminous (tectosilicate) glass powders of Li2O×Al2O3×SiO2 (LAS), Na2O×Al2O3×SiO2 (NAS) and MgO×Al2O3×SiO2 (MAS) systems by pressure loading and vacuum extraction in the temperatures range 210–310 °C. With this method, both the solubility S and the diffusivity D were determined, while the permeability was given by the product SD. For all glasses, S was found to decrease with temperature, while D increased. Since the activation energy of diffusion of H2 molecules exceeded that of dissolution, permeation increased slightly with temperature. When extrapolated to standard conditions (25 °C), the permeability of tectosilicate glasses was found to be only 10-22–10-24 mol H2 (m s Pa)-1, which is 8–10 magnitudes lower than most polymers. Thin glass liners of these compositions are expected to be the most effective barrier for tanks of pressurised hydrogen.
Tanıkların Dilinden Sovyetler Birliği Döneminde Müslümanlara Uygulanan Din Politikaları: Kırgızistan Örneği
Authors: KÖYLÜ Mustafa , BEKMURZAEVA Mirgül , RAHMATİLLAEVA Dilnoza
Published: June 2023

Sovyetler Birliği döneminin en belirgin özelliklerinden birisi de, dine ve dindarlara karşı yapılan baskılardır. Kendisine dini ve dindarları bir tehdit olarak gören yeni rejim, kendi hegemonyası altındaki insanları dinden uzaklaştırmak ve yeni bir “Sovyet insanı” yetiştirmek için her türlü yöntem ve metodu kullanmıştır. Bu bağlamda kilise ve cami ayrımı yapmadan öncelikli olarak ibadethaneleri ve din eğitimi veren kurumları kapatmış, sonra da okullarda ateisttik bir eğitim vererek, bireysel ve toplumsal anlamda pek çok dini kısıtlayıcı uygulamalar yapmıştır. Sovyetler Birliği döneminde uygulanan din dışı uygulamalara yönelik olarak günümüze kadar pek çok kitap ve makale yazılmış ve bilimsel tezler yapılmıştır. Ancak bizzat o dönemde yaşayan kişilerin dilinden o dönemin uygulamalarına yönelik her hangi bir çalışmaya rastlanmamıştır. İşte bu makalede, Kırgızistan özelinde, o dönemde yaşamış kişilerin kendi tecrübelerinden yola çıkarak, ne tür dini baskılar yapıldığı ve Kırgız toplumuna nasıl bir etki ettiği ortaya konmaya çalışılmıştır. Bu amaçla farklı yaş ve özellikleri dikkate alınarak o dönemde yaşamış, 20 kişiyle mülakat yapılmış ve o dönemde uygulanan dinsizleştirme politikalarına ilişkin tecrübelerinin aktarılması sağlanmıştır. Araştırmanın en önemli amaçlarından birisi de, sadece o dönemde yaşanan olumsuzlukları aktarmak değil, aynı zamanda o yaşananlardan dersler çıkararak daha güvenli ve huzurlu bir geleceğin inşasına katkı sunmaktır.
Bir Peygamber Olarak Hz. İbrahim’in Dualarındaki Tasavvufî ve Psikolojik Temalar
Authors: SAYIN Esma
Published: June 2023

BİR PEYGAMBER OLARAK HZ. İBRAHİM’İN DUALARINDAKİ TASAVVUFÎ VE PSİKOLOJİK TEMALAR

Öz

Hz. İbrahim’in tevhid inancını yansıtan sağlam bir ahlakı ve kişilik yapısı olduğu için Hz. İbrahim’in makamı, Allah’ın dostu olma makamıdır. Hz. İbrahim, Allah dışındaki her şeyle bağlarını koparıp atmış ve Allah’tan başkasına gönül vermemiştir.

Yüce Allah, Hz İbrahim’in karakterini bütün âleme ve insanlığa örnek kılmıştır. Bütün insanlık âlemine örnek olan Hz. İbrahim’in şahsında, salli-barik dualarında dostluk makamına ermiş bütün dost kullar, dua ile anılır. O’nun kalp makamını içselleştiren insan, önce kulluğun özünü sonra da bütün tevhit inancına ait insanlık ailesini dostluk ve duayla kucaklar.

Bu makalemizde bir peygamber olarak Hz. İbrahim’in dualarındaki tasavvufî ve psikolojik temalar ele alınarak incelenecektir. Bu kapsamda Hz. İbrahim’in dualarında geçen muhâsebe ve kendini sorgulama, istikâmet ve duygusal-zihinsel tutarlılık, tevekkül ve kendini tanıma-kendini aşma, ihlâs ve iç güdümlü dindarlık-sağlıklı ruh yapısı, tevbe ve kendini yenileme anlamlılık üretkenlik duygusu, hayâ ve kendini kontrol-sosyal ve ahlaki değerleri koruma konuları arasındaki bağlar incelenip yorumlanacaktır.
Evaluación clínica del paciente con síntomas del tracto urinario inferior
Authors: Valdevenito S. Juan Pablo , Álvarez O. Diego , Kobus G. Cristóbal , Bull C. Leonardo
Published: June 2023

Lower urinary tract symptoms are divided into three groups, storage, voiding and post

micturition symptoms. Their level of agreement with urodynamic investigation is poor. Clinical

history should be complemented by the application of validated symptom questionnaires

and the recording of urinary events. Here we refer to: a) the International Consultation on

Incontinence Questionnaire, Short Form (ICIQ-SF), b) the Urogenital Distress Inventory - Short

Form (UDI-6) and Incontinence Impact Questionnaire – Short Form (IIQ-7), c) the urinary

incontinence Severity Index and d) the American Urological Association Symptom Index. The

recordings of urinary events can be done in three main forms: a) micturition time chart, b)

frequency volume chart, and c) bladder diary. The International Consultation on Incontinence

Questionnaire bladder diary (ICIQ bladder diary) is the only one validated. Physical exam should

include abdominal and genital examination, covering pelvic organ prolapse quantification in

women, prostate evaluation in men, pelvic floor muscle function evaluation in both genders, and

a neurologic examination focused on evaluation of the sacral nerves. It is useful to supplement

the physical examination with the evaluation of the mobility of the bladder neck and proximal

urethra through the Q-tip test, and with the quantification of urine leakage through the pad test
Abstracts de publicaciones nacionales ISI 2016
Authors: Hospital Clínico Universidad de Chile Revista
Published: June 2023

El material que se presenta a continuación proviene de los datos proporcionados por la OAIC (Oficina de

Apoyo a la Investigación Clínica) de nuestro Hospital, así como de los recolectados por nuestra Revista
El estrés materno como factor de riesgo para fisuras labio-palatinas
Authors: Nazer H. Julio , Finschi P. Andrés , López-Camelo Jorge , González G. Gisella
Published: June 2023

Introduction: several studies have shown an association between stress caused by natural disasters, acts of terrorism and war, which have been corroborated by experimental studies in rats, with presence of oral clefts (FO) in the children of women who suffered stress in the first weeks of pregnancy. Objectives: To demonstrate the relationship between stress caused by the earthquake and tsunami that struck the central and south regions of Chile, on February 27, 2010 and the prevalence rate of FO in the disaster area. Material and Methods: Registration of ECLAMC (Latin American Collaborative Study of Congenital Malformations) Period 2000- 2011. With this information we created two groups: Group 1: Children born before the event, from 2002 to 2009 up to 6 months after earthquake, that means August 2010. Group 2: the postearthquake period, from the seventh month after the earthquake (September) until the end of 2011. Results: the prevalence of oral clefts of the first group was 0.88 per thousand births (0.57 for cleft lip and cleft palate 0.30) .and the second group of 1.07 per thousand, (0.70 cleft lip and cleft palate 0.37) statistically significant difference (p
Análisis epidemiológico de onicomicosis diagnosticada por laboratorio en pacientes menores de 15 años
Authors: Palma D. Carlos , Zemelman D. Viviana , Stevens G. Jonathan , Araníbar D. Ligia , Zapata M. Solange , Hernández V. Alicia
Published: June 2023

Onychomicosis was considered uncommon in children. During recent years an increase in its

frequency has been reported in children worldwide. This survey was carried out to estimate

the frequency of causal agents of fungal nail infections in children and adolescents (0-15 years

of age) during the period 2006-2016 in the Skin Laboratory of Clinical Hospital, University

of Chile. It was a descriptive, retrospective analysis of all positive culture of children nails. A

total of 1626 culture was analyzed. Cultures were positive in 417 cases (25,6%). Average

age of patients with positive culture was 9,37 ages. Of the total positive culture, 42,9%

was females and 57,1% was males. Toenails were more affected (90,6%) than finger nails.

Trichophyton rubrum (66,9%), was the predominant pathogen isolated followed by Candida

spp (26,1%) Trichophyton rubrum + Candida spp (3,8%) Trichophyton mentagrophytes (2,6%)

and Trichophyton rubrum + Trichophyton mentagrophytes (0,5%). Fungal fingernail infection by

Candida spp. was the most common (66,7%) and Trichophyton rubrum was the most common

in toenail (70,6%). We found a decrease of Candida spp. with age. The results of our study show

that onycomichosis in children and adolescents is not exceptional and should be considered in

the differential diagnosis of nail plate disorder in children.
Síndrome de Vogt-Koyanagi-Harada en niños
Authors: Velásquez R. Víctor , Araya C. Javiera , Pérez V. Fernanda , Morales E. Sergio , Fuentes G. Esteban , Romero C. Pablo
Published: June 2023

Introduction: Vogt-Koyanagi-Harada (VKH) syndrome is a systemic inflammatory disease that causes chronic and bilateral granulomatous panuveitis, usually described in adults. Objectives: To describe manifestations and complications of VKH in pediatric patients. Methods: Retrospectivedescriptive study upon patients less than 14 years-old with VKH, attended from January 1985 to July 2010 in three different centers. Results: A total of 17 patients (34 eyes) were studied; 9 (53%) female. The mean age was 10.8 years-old. Among extraocular manifestations; neurological (71%), dermatological (29%) and auditive (24%) signs were observed. Ocular findings included optic-disc involvement (94%), anterior uveitis (79%), choroiditis (77%), serous retinal detachment (71%) and vitritis (71%). Initial visual acuity (VA) was ≤0.05 in 47% of cases and ≥0.6 in 12% of patients. 71% presented complications: glaucoma (20 eyes), sinechiae (10 eyes), maculopathy (6 eyes) cataract (5 eyes) and ptisis bulbi (1 eyes). 35% received only corticosteroids and 65% inmunosupressive drugs. After treatment, 6% had VA ≤0.05 and 59% ≥0.6. Ten patients (59%) recurred: 30% compromising posterior pole, and 50% recurred >3 times. Conclusions: VKH in children is infrequent. It presents with optic-disc involvement and complications of posterior pole. It requires a high degree of suspicion, quick evaluation and early treatment, which include inmunosupressive and extended corticosteroid therapy. Nevertheless, a high rate of recurrence is seen among this group of patients.
Tuberculosis extrapulmonar con compromiso peritoneal. Reporte de caso clínico y revisión de literatura
Authors: Gatica T. Consuelo , Garrido V. Paola , Subiabre G. José
Published: June 2023

Extrapulmonary tuberculosis accounts for a significant proportion of tuberculosis cases worldwide (about 20-25% of the cases). Nevertheless, the diagnosis is often delayed or even missed due to insidious clinical presentation and poor performance of diagnostic tests. Peritoneal tuberculosis is due to the infection of Mycobacterium tuberculosis in the peritoneum. It represents 0.7% of total cases of tuberculosis. This disease can mimic malignancy specially in women, because of its clinical presentation with ascites, weight loss and similar radiological sings. The phenomenon of migration, the increased use of immunosuppressive therapy and the epidemic of AIDS have contributed to a resurgence of this disease. We present the clinical case of a Haitian woman who presented ascites, abdominal pain and weight loss with radiological signs that suggested peritoneal carcinomatosis, in which further studies of ascitic fluid showed elevated adenosindeaminase, a specific and sensitive finding for tuberculosis.
Disfunción cognitiva postoperatoria
Authors: Brunet L. Luis , Penna S. Antonello
Published: June 2023

Cognitive function may decline after surgical procedures. Cognitive postoperative dysfunction

(CPOD) is subtle and requires neuropsychological test for diagnosis. Multifactorial in origin,

its cause is unknown but associated with different risk factors, which especially affects origin

people submitted to extense surgery. CPOD is transient, but in some cases is prolonged and

is associated with an increase in mortality and permanente disability. The aging population

and the increase of elderly patients requiring surgery a cause of concern. Clinical studies are

required to recognize preventive and therapeutic measures to reduce CPOD in the future.
Hipovitaminosis D en pacientes hospitalizados por trastornos por consumo de sustancias en Unidad de Adicciones del Hospital Clínico Universidad de Chile
Authors: Arancibia R. José , Koch M. Matías , Tapia G. Carolina , Ibáñez P. Carlos
Published: June 2023

The pathological consumption of alcohol and other drugs is associated with calcium metabolism disfunction through different pathways. Hypovitaminosis D contributes to acute a chronic neuronal injury in alcohol dependent patients. We do not have national evidence regarding the presence of hypovitaminosis D in addicted patients and there is a lack of information in the literature regarding polysubstance users. In this retrospective study, we evaluate the presence of hypovitaminosis of D in Substance Use Disorder inpatients treated in the Psychiatric Clinic of the University during the months of August to November 2017 and we described their main characteristics. 24 patients were evaluated, 19 of whom presented levels lower than 30 ng/ml of Vitamin D. Of those patients with hypovitaminosis 79% were men and 90% of them consumed alcohol, although in only 26% alcohol was the main substance. The main substance reported by the patients was cocaine (37%), smokable cocaine (32%) and marijuana (5%).

Despite the methodological limitations of the study and the high prevalence of Hypovitaminosis D reported in the Chilean population, the results of this study suggest the need for a systematic evaluation of Vitamin D levels in patients hospitalized for addictions to adequately supplement those who require it.
Osteomielitis vertebral por Candida parapsilosis, reporte de un caso y revisión bibliográfica
Authors: Maureira E. Valeria , Pérez-Luco A. Tomás , López F. Valentín , Olivares C. Roberto , Ávila O. Fernanda
Published: June 2023

Invasive candidiasis is a pathology associated with known risk factors. In the past decades its incidence has increased, due to an increment in new non-albicans species, one of which is Candida parapsilosis. The most frequent presentation still is candidemia, however, candidial osteomyelitis cases have been described, usually compromising the axial skeleton. In this article, we report a case of candida parapsilosis spondylodiscitis, along with a review of the published literature of the subject.
Mediadores inflamatorios y su influencia en la evolución del cáncer colorrectal
Authors: De la Fuente L Marjorie , Hermoso R. Marcela , Abedrapo M. Mario , Carrillo G. Katya , López N. Sebastián
Published: June 2023

Colorectal cancer (CRC) is one of the most important causes of death from cancer worldwide, and in Chile, the mortality rate has increased considerably in recent years. Locally, diverse cells of the immune system can infiltrate the tumor, generating a tumor microenvironment and playing an important role in cancer progression. Inflammatory cells that infiltrate the tumor

secrete cytokines and chemokines, inflammatory mediators, which activate immune networks and participate in the control of proliferation and survival of malignant cells, and processes such as angiogenesis and metastasis. Thus, elevated levels of various inflammatory mediators, such as TNF-α, IL33 / ST2 cytokines, chemokines such as CCL3 and CCL4 have been detected

in different types of neoplasms, including CCR. The inflammatory reaction and changes in the levels of inflammatory mediators at the tumor site could account for the evolution of cancer, making them attractive the future predictive markers of disease or possible therapeutic targets. Therefore, in this review we emphasize in cytokines and chemokines involved in CRC and its association with carcinogenic mechanisms and tumor progression
Validación de criterios ecográficos IOTA (International Ovarian Tumor Analysis Group) para caracterizar masas anexiales y determinar riesgo de malignidad en un grupo de mujeres con sospecha de cáncer de ovario
Authors: Preisler R. Jessica , Burgos S. Nelson , Cisternas O. Daniela , Gayan P. Patricio , Chávez R. Ignacio , Aleuanlli A. María Cristina , Bustos S. Carolina , Barros B. Antonia , Hurtado T. Iván
Published: June 2023

Epithelial carcinoma of the ovary is a gynecological malignancy associated with high mortality

rate due to diagnosis in advanced stages, which occurs in more than 75% of the cases.

Recent strategies in reducing mortality have been studied, however screening tests have not

demonstrated to help in the diagnosis at early stages. Subjective impression of the examiner

using transvaginal ultrasound is considered the best method to discriminate between benign

and malignant adnexal tumors. The International Ovarian Tumor Analysis Group (IOTA) based

on ultrasound features of the adnexal masses, has developed robust rules and prediction

models that can be used by different examiners in various clinical settings.In Chile during

2012, national guidelines about epithelial ovarian cancer were published, establishing referral

and management criteria. Little mention about ultrasound exam was included: all “solid

tumors or complex adnexal masses” are sonographic criteria to refer patients to gynecologic

oncology units. Considering that many functional or benign pathologies can be classified as

“complex tumors”, it is important to use validated prediction models to improve accuracy of

ultrasonography and therefore optimize the referral to gynecological oncologists and avoid

surgeries of misclassified adnexal pathologies.
Las alteraciones de la microbiota intestinal en la patogenia del hígado graso no alcohólico
Authors: Guíñez F. Dannette , Poniachik T. Jaime , Gotteland Martín , Magne Fabien , Urzúa M. Álvaro , Iracheta M. Alexis , Pérez de Arce O. Edith , María Madrid S. Ana , Videla C. Luis A. , Vera P. Daniela , Beltrán M. Caroll J.
Published: June 2023

Non-alcoholic fatty liver disease (NAFLD) is currently considered in Chile and worldwide, as the main cause of cirrhosis and liver transplantation. It is therefore one of the main public health objectives for reducing its prevalence. In last years, it was suggested that the intestinal microbiota (IM) might contribute to the pathophysiology of NAFLD, as well as in the progression toward nonalcoholic steatohepatitis (NASH) and cirrhosis. It is known that changes in the composition of IM are associated with alterations in intestinal permeability and the production of inflammatory metabolites. These alterations are part of the pathophysiological mechanisms leading to the development of NASH. However studies on MI in patients with NAFLD and NASH in Chile are scarce. Through a research grant, recently awarded at the Hospital Clínico Universidad de Chile, we aim to confirm and characterize the intestinal dysbiosis associated with NAFLD in Chilean patients and to establish the relationship between the changes in microbial composition with the progression of liver damage. The description of these alterations represents an opportunity to explore new therapeutic approaches for future interventions. In effect, through the restoration of an intestinal microbial environment towards homeostasis in these patients, we expect to reverse or improve the progression of damage provoked by this disease.
Lumbago en el embarazo
Authors: Urturbia M. Viviana
Published: June 2023

Low back pain is one of the most frequent causes of pain during pregnancy and often gets

worse as it progresses. This pain can interrupt daily activities, work and has a great impact on

the quality of life of the pregnant woman. Its etiology is unknown and there are several theories

that would explain that the genesis of pain is multifactorial. As the pregnancy progresses, there

are several physiological changes that occur in the woman’s body, which could contribute to

triggering a low back pain. It has been shown that an adequate diagnosis and early management

based mainly on education, exercise and physiotherapy, achieve good results in the control of

pain and improve the quality of life. In certain cases, the use of drugs for a limited period of

time and with medical supervision may be beneficial in controlling pain.
Disfunción inmunológica en enfermedad de Alzheimer; proinflamatoria en etapas iniciales y regulatoria, y exhausta en etapas avanzadas
Authors: Romero U. César Antonio , Rogers C. Nicole , San Martín R. Carol , López N. Mercedes , Behrens P. María Isabel
Published: June 2023

Alzheimer disease (AD) is the main cause of dementia worldwide and a source of important population morbidity and mortality. It is estimate that its prevalence will increase dramatically in the upcoming years. The classical clinical presentation of AD is an amnesic hippocampal syndrome, and Mild Cognitive impairment (MCI) is considered the initial stage between normal cognition and dementia. The most accepted pathogenesis establishes amyloid beta (Ab) deposition in brain parenchyma as the initial mechanism, followed by the intracellular accumulation of hyperphosphorylated tau finally leading to the loss of synapses and neurons. Recently, the study of AD pathogenesis is focusing on immune mechanisms as main actors of disease development. Microglia is the macrophagic resident cell in the central nervous system (CNS), and initiates the inflammatory response and Ab phagocytosis, interacting with other glia and recruiting diverse immune cells to the CNS. The role of the adaptive immune system, and, especially T lymphocytes’ role, is still controversial. We hypothesize that the pathogenesis of AD is dynamic; with a preponderant proinflammatory activity initially, but later on, the persistent presence of Ab due to the lack of its proper elimination leads to a phenomena of lymphocyte dysfunction and immunological tolerance that have a deleterious role at advanced stages of the disease.
Terapias para la comunicación en personas con esclerosis múltiple
Authors: Tapia S. Sara , Matus R. Paulina
Published: June 2023

People with Multiple Sclerosis (MS) can present a variety of communication disorders that affect their roles and social participation, affecting their quality of life and that of their environment. An early approach to these people and their communication difficulties could improve/compensate/facilitate communication, minimizing the effects on their daily life. Purpose: To contribute with recommendations for communication therapy in people with MS. Method: narrative literature review related to the topic. Results: There are few investigations focused on the intervention of communication in people with MS, those found are works in small populations, with evaluations at the beginning and at the end of therapy. The most promising studies are those that show specific effects on speech, through the LSVT LOUD, which not only improves communicative effectiveness, but has also shown improvements in dysphagia (eating disorder). significant to consider interventions with the environment and aimed at the quality of life of the affected individuals and families. Conclusions: The different presentations that MS has and its individual characteristics in each person, makes it difficult to have specific evidence on the most effective types of therapy. Despite this, it is possible to use therapies focused on different communication symptoms and adapt them under certain considerations to address communication in people with MS.
Sustentabilidad hospitalaria, calidad y seguridad del paciente en el Hospital Clínico Universidad de Chile
Authors: Sakurada Z. Andrea , Mena V. Sandra , Salazar C. Carolina , Vidal C. Mario , Villaleiva C. Soledad , Quintana C. Magyolue
Published: June 2023

The sustainability of the Universidad de Chile Clinical Hospital must be understood comprehensively; providing higher quality and safety for our patients, ensuring highest standards of medical care. The quality of care must be understood not only in complying
with the minimum standards to accredit and grant GES benefits, establish agreements with health insurers and be financially competitive; It must be incorporated into its management the dimensions of quality - effectiveness, efficiency, accessibility, safety, equity and patient centered care- minimizing the costs of non-quality work. Our Clinical Hospital, as our country’s main training center in healthcare professions, must include training at the undergraduate students’ curriculum in quality and patient safety issues.
BULGAR EDEBİYATINDAKİ İLK İSTANBUL SEYAHATNAMESİ ÜZERİNE BAZI GÖZLEMLER
Authors: MEVSİM Hüseyin
Published: June 2023

Yüzyıllar boyunca İstanbul; Bulgar siyasi, askerî ve manevi tarihinde tayin edici rol oynamıştır. Günümüzde de her Bulgar, Boğaz kıyısındaki eşsiz şehri kendine çok yakın bulur. Ancak Bulgar edebiyatında İstanbul’u odağına alan ilk seyahatname, oldukça geç, 19. yüzyıl sonlarında kaleme alınır. Bu gecikmenin açıklanabilmesi için Bulgar’ın içindeki seyyahın, Bulgar toplumunun kaçınılmaz sancılar beraberinde modern hayata eklemlenmeye çabaladığı 1890’larda ortaya çıktığının göz önünde bulundurulması gerekir. Daha önceki yıllarda yazılan ve seyahatname türünün başlıca ögelerini barındıran eserlerde yerel coğrafyanın kapsandığı, Osmanlı İmparatorluğu sınırlarının dışına çıkılmadığı görülür.

Bu çalışmada payitahtın Bulgar tarihindeki yeri, ünlü şair ve gazeteci Petko Slaveykov’un İstanbul tasviri (1866) ve ilk doktoralı Bulgar hekim olan Dimitır Mollov’un bir dergide yayınladığı İstanbul izlenimleri (1888) hakkında kısaca bilgi verildikten sonra Bulgar edebiyatında ilk İstanbul seyahatnamesinin yazarı olan Todor Yankov’un hayat hikâyesi ve anılan eserle ilgili bazı gözlemler üzerinde durulmaktadır. Avrupalı bir seyyah yaklaşımı içinde şehrin sadece parıltılı yerlerini ve mekânlarını gezmekle yetinmeyen yazar, İstanbul’un eğri sokaklarına iner, caddelerde sokak köpekleri ve faytonlar arasında yürür, çarşılarda dolaşır, kahvehanede Türk kahvesi yudumlar, tekkede müridin tutkusuna ortak olur. Todor Yankov’un sıradan insana ve tekdüze akan hayatı canlandırmaya yönelik çabası, seyahatnameye ayrı değer katar ve özgünlük kazandırır. Kadim şehirde yalnızca Bulgar millî ve manevi tarihinin iz düşümleriyle ilgilenmemesi ise Avrupa değerlerini benimsemiş, farklı dünya görüşüne sahip bir kuşağı temsil etmesiyle açıklanabilir.
Administration of fermented soursop (Annona muricata) leaf water extract through drinking water on the performance of joper male chickens
Authors: Artawiguna I Ketut Nopa , Nuriyasa I Made , Siti Ni Wayan
Published: June 2023

This study aims to determine the effect of fermented soursop (Annona muricata) leaf water extract on the performance of male joper chickens. The experimental design used was a completely randomized design (CRD) with 5 treatments and 4 replications, each experimental unit consisting of 3 chickens aged 2 weeks. The treatment given was fermented water extract of soursop leaves (Annona muricata) through drinking water, namely P0 : 0%, P1: 1%, P2: 2%, P3: 3% and P4: 4%. The variables observed were the performance and microbes of the digestive tract. The results showed that administration of fermented soursop (Annona muricata) leaf aqueous extract had a significant effect (P<0.05) on ration consumption, drinking water consumption, weight gain, final body weight, feed conversion ratio (FCR), total bacteria (TPC). escherichia coli and coliform. Based on the results of the study it can be concluded that administration of fermented soursop (Annona muricata) leaf water extract can improve the performance of joper male chickens with the best results at 2% administration via drinking water.
Microscopic Modelling of Car-Following Behaviour: Developments and Future Directions
Authors: He Yinglong , Zhou Quan , Wang Chongming , Li Ji , Shuai Bin , Lei Lei , Xu Hongming
Published: June 2023

Review Microscopic Modelling of Car-Following Behaviour: Developments and Future Directions Yinglong He 1, * , Quan Zhou 2, * , Chongming Wang 3, Ji Li 2, Bin Shuai 2, Lei Lei 4, and Hongming Xu 2 1 School of Mechanical Engineering Sciences, University of Surrey, Guildford GU2 7XH, UK 2 Department of Mechanical Engineering, University of Birmingham, Birmingham B15 2TT, UK 3 Institutes for Future Transport and Cities, Coventry University, Coventry CV1 5FB, UK 4 College of Information Science and Engineering, Jiaxing University, Jiaxing 314001, China * Correspondence: yinglong.he@surrey.ac.uk (Y.H.); q.zhou@bham.ac.uk (Q.Z.)     Received: 17 April 2023 Accepted: 21 June 2023 Published: 27 June 2023   Abstract: The study of driving behaviour has become increasingly important in the development of transport and vehicle technologies. Microscopic traffic models simulate individual driver behaviour to understand and predict traffic flow. One of the key components in microscopic simulation is the car-following (CF) model, which describes the behaviour of vehicles in terms of how they follow the vehicle in front of them. Some excellent reviews of CF models are available, however, to the best of the authors’ knowledge, none of them provides a comprehensive analysis that covers and compares different model categories including kinematics-based, dynamics-based, psychological-based, and learning-based. This paper, therefore, provides an overview of the developments and future directions of CF models, encompassing all the previously mentioned categories. It first introduces the fundamental concepts of traffic models, in particular CF models. It then reviews the progress of CF models, which are classified into the above four categories. The advantages and limitations of existing CF models are discussed. The paper further identifies several research directions for future work, including the integration of emerging vehicle technologies, the incorporation of real-world traffic data, and the calibration and validation of model parameters. It concludes by emphasizing the importance of interdisciplinary collaboration and the need for further research to improve the accuracy and practicality of CF models.
Relationship of Innovation and Market Orientation With the Profitability of SMEs in Mexico
Authors: Rodriguez Alfonso Martin , Diaz de Leon Virginia Guzman , Sanchez Maria del Carmen Bautista , Alonso Jose Raul Franco
Published: June 2023

The objective of this research is to analyse the effect of innovation and market orientation of small and medium-sized enterprises (SMEs) on their profitability in 2018 in Mexico, because they are two key elements in the development and growth of these companies, which compete with large companies within a globalized and constantly evolving market. For this analysis, an empitical study was carried out through a survey on a sample 300 companies selected by simple random sampling adapting the scales of Kohli & Jaworski (1990) to measure market orientation, for innovation the scale proposed by the OECD (2005) was adapted and business profitability and adaptation was made to the cale proposed by Gadenne, Mia, Sands, Winata, & Hooi (2012). Reliability and validity of the scales were evaluated through the Confirmatory Factor Analysis, which shows that the higher level of orientation to the SME market, the higher level of business profitability so companies must seek to implement innovation activities in their products, processes and management to see better, results reflected, in addition, the influence exerted by market orientation on innovation activities drives the company to meet the needs of the client and in this way conquering their preference.
65 Yaş ve Üzeri Çoklu İlaç Kullanımı Olan Bireylerin Akılcı İlaç Kullanımı Bilgi Düzeyleri
Authors: Yayın Esranur , Yayın Hasan Esad
Published: June 2023

Amaç: Yaşlanmayla birlikte artan kronik hastalıklar çoklu ilaç kullanımına yol açmaktadır. Ülkemizde polifarmasi görülen hastaların çoğu dünya çapında da olduğu gibi 65 yaş ve üzeri hastalardan oluşur. Amacımız; aile hekimliği birimine kayıtlı yaşlı hastaların akılcı ilaç kullanımı hakkında bilgi düzeylerini saptayarak hastaların yaşam kalitesini ve tedaviye uyumunu artırmak, ilaç etkileşimlerini ve tedavi maliyetlerini azaltmak için farkındalık oluşturmaktır.Yöntem: Kesitsel ve tanımlayıcı özellikteki bu çalışmanın evrenini bir aile sağlığı merkezine kayıtlı, 65 yaş ve üzeri, çalışmaya katılmak için gönüllü beş ve üzeri ilaç kullanan 163 hasta oluşturmaktadır. Hastaların tamamı ile yüz yüze görüşülerek sosyodemografik veri formu ve 21 maddeden oluşan Akılcı İlaç Kullanım Ölçeği uygulanmıştır. Verilerin incelenmesinde SPSS 22.0 paket veri programı kullanılmıştır.Bulgular: Çalışma yaşları 65 ile 95 arasında değişmekte olan, 66’sı (%40,5) erkek ve 97’si (%59,5) kadın olmak üzere toplam 163 olgu ile yapılmıştır. Olguların %49,1’i akıllı ilaç kullanım bilgisine sahipken, %50,9’u değildir. Yaş grubu, cinsiyet, medeni hal, kronik hastalık varlığı, sigara kullanımı ile akılcı ilaç kullanım bilgisine sahip olma arasında istatistiksel olarak anlamlı bir ilişki yoktur. Lisans ve üzeri mezunlarının akılcı ilaç kullanım bilgisine sahip olma oranları, okur yazar olmayan ve ilköğretim mezunlarından istatistiksel olarak anlamlı düzeyde yüksektir.Sonuç: Polifarmasisi olan bireylerle yapılan bu çalışmada bilgi düzeylerinin literatürle benzer olması polifarmasiye yol açan, hastaların bilgi düzeylerinden başka etmenlerin olduğunu göstermektir. Türkiye’de akılcı ilaç kullanımı bilgi düzeyinin özel gruplar üzerinde değerlendirildiği tüm çalışmalarda en temel belirleyici faktör bireylerin eğitim düzeyidir. Akılcı ilaç kullanımı bilgi düzeyinin arttırılması için daha kapsamlı projeler yürütülmeli ve bu projeler özellikle bağımlı yaşlı grubuna bakım veren aile üyelerini de kapsamalıdır.
Reactive-Advective-Diffusive Models for the Growth of Gliomas Treated with Radiotherapy
Authors: Machado Bruno da Silva , Alvarez Gustavo Benitez , Cesar Lobão Diomar
Published: June 2023

Gliomas are malignant brain tumors responsible for 50% of primary human brain cancer cases. They have a combination of rapid growth and invasiveness, and high fatality rates with a median survival time of one year. Mathematical models that describe its growth have helped to improve treatment.  In this paper, a combined model formed by terms of two other models known in the literature is analyzed. The combined model is a Reactive-Advective-Diffusive partial differential equation, which is solved by combining the finite difference method, the Crank-Nicolson method and the upwind method. Logistic growth is used for cell proliferation ensuring a saturation threshold for glioma growth, which is crucial to properly estimate patient survival time. The well-known linear-quadratic radiobiological model is used to describe cell death due to radiotherapy treatment. Two initial conditions are compared in the simulations, indicating the need for further studies to have a model as close as possible to reality. Simulation results are shown for four scenarios: no radiotherapy, application of a single dose, and two dose fractionation schemes.
A Study on the Improvement Plan to Increase Participation of Virtual (VR) Museum Visitors
Authors:   Korea Society of Public Design, Li Li-Wei , Kim Eung Hwa
Published: June 2023

As a public place for collecting, researching and displaying cultural relics, museums provide people with opportunities to get in touch with culture and history, visit and learn, and are deeply loved by people. With the development of science and technology, virtual museum has become a new form used in many museums. Virtual museums use advanced technology to provide visitors with a rich museum experience on a network platform. In the “2021 Global Theme Parks and Museums Report” published by TEA, the 6 most popular virtual museums were selected as the research objects. The research method is to analyze the current situation of the virtual museum and the experience of the visitors, grasp the existing problems of the virtual museum, and propose the direction of improvement. Through questionnaire survey and spss analysis method, it verifies the impact of various factors on tourists' participation, and deeply understands the needs and expectations of tourists. The results of the study show that the participation of visitors in the virtual museum is mainly affected by various factors such as visual effects, interactivity, number of exhibitions/area, content of virtual exhibits, and technology. These factors determine the overall experience and satisfaction of visitors to the virtual museum. These factors can be improved in the future to promote the development of virtual museums.
The Effect of Appeal Type and Graphic Representation Match on Online Crowdfunding
Authors:   Korea Society of Public Design, MENG YUE , Kim Eung Hwa
Published: June 2023

Social media-mediated online crowdfunding campaigns are an effective way to help nonprofit organizations raise funds. The purpose of this study is to design persuasive online fundraising messages to convince potential supporters to participate in online crowdfunding campaigns. The research methodology is as follows. First, an examination of online crowdfunding theory. Second, the components of online crowdfunding messages are analyzed. Third,the visual characteristics of existing online crowdfunding messages are analyzed to design messages for nonprofit environmental organizations. Finally, to verify the persuasive effect of matched online crowdfunding messages. SPSS26.0 data analysis software was used to compare the differences in persuasive effects of the four design options. The results showed that the desired persuasive effect could be obtained when the appeal type and graphic expression were consistent. Specifically, online crowdfunding messages consisting of emotional and visual graphics, rational and metaphorical graphics were likely to persuade potential sponsors to participate in the donation. This study is important in helping nonprofit environmental organizations to successfully raise funds for their campaigns through online crowdfunding, as they are committed to public service.
K-EDU MON CENTER CI design
Authors:   Korea Society of Public Design, Jeong Ga-Ram-Sol , Park Hyeon-Jin , Jeong Wooramsol , Jeong Hee-Jeong
Published: June 2023

The world's disproportionate population structure is accelerating. As a result, the government is implementing various policies to ease the shortage of human resources and improve national growth engines. We designed the CI(Corporate Identity) of K-EDUMON CENTER, a global local education program for Mongolian non-professional workers to qualify for stay in Korea. We have established a design development process through CI theory analysis, current status of “K-EDUMONNTER”, and similar CI/BI development cases. We have developed CI basic systems and applications that provide users with specific impressions and perceptions and reflect organizational goals and values. Integrated image building enables the developed CI to be utilized for user communication and various marketing activities.
The Role of Interactive Technologies in Optimizing the Process of Patient Treatment: Prospects and Challenges for Health Care
Authors: Anikin Nikita , Dik Anastasiia , Yambrovskaya Diana , Mikhaylova Ksenia , Markvashev Taras , Petrenko Elena
Published: June 2023

The introduction of medical digital technologies can provide better access and flexibility of healthcare for the population.
It includes the availability of open information about health, treatment, complications, and recent progress in biomedical
research. Nowadays, even in low-income countries, diagnostic and medical services are becoming more accessible.
However, many issues related to digital health technologies remain unresolved, including reliability, security, testing, and
ethical issues.The penetration of AI currently affects almost all areas of work of medical organizations and government
and supervision bodies in the field of healthcare, as well as all major nosological groups. The leading areas of AI application
are: medical diagnostics and image analysis, predictive clinical and managerial analytics, medical decision support
systems, data analysis of wearable devices, telemedicine, monitoring of patients with chronic non-communicable diseases,
virtual assistants, including robot-assisted surgery, decision assistance mental health problems, etc.This article explores
the role of interactive technologies in optimizing the patient care process and discusses the prospects and challenges they
present for healthcare. In recent years, interactive technologies such as mobile applications, virtual reality, remote
medical consultations and electronic health monitoring systems have become increasingly common in medical practice.
Digital platforms can help optimize patient diagnosis, counselling and treatment. However, due to the lack of official
regulations and recommendations, stakeholders, including private and public organizations, face the problem of adequate
verification and testing of new digital health technologies. In this regard, proper scientific research is needed before a
digital product is deployed for the health sector.The authors emphasize that interactive technologies have a significant
potential for optimizing the process of treating patients in healthcare. They can improve the availability and quality of
medical care, as well as increase patient satisfaction.
Evaluation of laser-induced breakdown spectroscopy (LIBS) applications in the aspect of forensic chemistry
Authors: Islek Dilek , Kiris Eda , Karatas Omer , Holumen Nazli , Yukseloglu Emel
Published: June 2023

The most common definition of forensic science is the application of science to solve legal cases. In order to establish or rule out a connection between a suspect and a crime scene, forensic scientists analyze evidence collected from the crime scene, using multidisciplinary scientific methods (physics, chemistry, biology, mathematics, medicine, psychology, sociology, etc.). The identification of the sample and determination of whether two or more objects share a similar origin have been accomplished in forensic science using a variety of analytical techniques from past to present. However nowadays, with the developing technology, new methods that are more sensitive and easy to use are preferred. One of these techniques is Laser-Induced Breakdown Spectroscopy (LIBS). In forensic studies, LIBS is used to examine materials like counterfeit money, drugs, explosives, fingerprints, gunshot residue, ink, paper, hair, paint, glass, etc. On the other hand, it is more useful method compared to other methods due to the absence or simplicity of sample preparation, easy to operate, allowing the analysis of major, minor or trace elements and giving rapid results. This paper presents a review of the application of LIBS in forensic chemistry and the analytical results obtained with LIBS.
A contribution to complementary soft binary piecewise plus and gamma operations
Authors: SEZGİN Aslıhan , AKBULUT Emre
Published: June 2023

Molodtsov, in 1999, introduced soft set theory as a mathematical tool to deal with uncertainty. Since then, different kinds of soft set operations have been defined and used in various types. In this paper, it is aimed to contribute to the soft set literature by obtaining the distributions of soft binary piecewise operations over complementary soft binary piecewise plus and gamma operations.