bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of Wire Cut Electro Discharge Machining Process Parameters for HCHCr-D2 Steel
Authors: K Anand
Published: March 2023

Abstract: The process parameters for wire cut electro discharge are optimised in this paper. The analysis takes into account the process parameters pulse on time, pulse off time, and current. High Carbon High Chromium (HCHCr-D2) steel is a high tensile strength alloy that is typically utilised in cold dies and tooling applications that demand a high level of and dimensional accuracy. For the machining procedure, a rectangular-shaped plate of the alloy steel HCHCr-D2 was used. By examining the material removal rate (MMR) and surface roughness, wire cut electro discharge machine (WEDM) performance using a molybdenum wire has been evaluated (SR).
A Review on Privacy Preserving Using Machine learning and Deep Learning Techniques
Authors: Rajput Amit , Tiwari Suraksha
Published: March 2023

Abstract: In order to entice data custodians to provide precise documentation so that data mining can continue with confidence, protecting the confidentiality of healthcare data is crucial. Association rule mining has been extensively used in the past to analyze healthcare data. The majority of applications ignore the drawbacks of specific diagnostic procedures in favor of positive association criteria. Negative association criteria may provide more useful information when bridging disparate diseases and medications than positive ones. In the case of doctors and social groups, this is particularly accurate. Data mining for medical purposes must be done with patient identities protected, especially when working with sensitive data. However, it might be attacked if this information becomes public. In order to perform data mining research, technology that modifies data (data sanitization) that reconstructs aggregate distributions has recently addressed the importance of healthcare data privacy. This study examines data sanitization in healthcare data mining using metaheuristics in order to safeguard patient privacy. Studies on SHM have looked at the uses of IoT &/or Machine Learning (ML) within the field, as well as the architecture, security, & privacy issues. However, no studies have looked into how AI and ubiquity computing technologies have affected SHM systems. The objective of this research is to identify and map the primary technical concepts within the SHM framework.
ABOUT SOME QUESTIONS OF THE JURISDICTION IN BANCRUPTCY CASES OF THE CITIZENS
Authors:   Bryansk State Academician I.G. Petrovski University, Azarov Dmitry
Published: March 2023

The article describes the position of author about utilization of the legal norms, stipulating the opportunity of refusal to a debtor in the right of the exemption from the creditor’s claims after the finishing of bankruptcy procedure in relation to him.
Treatment and rehabilitation of patients with temporomandibular joints pathology
Authors: Yatsuk Andrey V. , Sivolapov Konstantin A.
Published: March 2023

Relevance. According to statistical observations, the pathology of the temporomandibular joints (TMJ) is often found in dental practice, and is accompanied not only by a pronounced pain syndrome, but also by the occurrence of internal disorders in the structure of the joints themselves. The article discusses the causes of diseases of the temporomandibular joints, gives a physiological justification for the principles of treatment of this pathological condition, indicating further principles of rehabilitation. The aim of the study is to develop principles for the treatment and rehabilitation of patients with TMJ. Materials and Methods. The condition of patients was determined on the basis of a comprehensive examination, including functional diagnostic tests, collection of anamnestic data, study of models of biomechanical occlusions, axonography, psycho-emotional state of patients using the SCL-90-R scale, quality of life. Results and Discussion. The pathology of the temporomandibular joint is considered as a disorder of its functioning, both in the absence of morphological changes and in their presence. In the absence of changes, the psychosomatic factor plays a decisive role against the background of stressful conditions (20-27 %). In the presence of pathological changes in the elements of the joint, the violation of occlusion comes first, which leads to a decrease in the elasticity of the articular surfaces, due to a change in the state of the synovial fluid. Conclusion. To prescribe therapeutic measures for the pathology of the temporomandibular joint, a specific triad of clinical manifestations is necessary: severe pain syndrome, limitation of movements of the lower jaw, internal disorders of the joint (detected using MRI). Rehabilitation of patients with TMJ diseases, according to our research, should be carried out in a complex of gnathological, conservative and surgical treatment. As a surgical treatment, we recommend: prosthetic synovial fluid, arthrocentesis, arthrolavage and prosthetics of the head and articular cavity of the condylar process.
Group B streptococcus in obstetrics: unsolved problems
Authors: Radzinsky Victor E. , Doronina Olga K. , Olenev Anton S. , Stetsyuk Olga V.
Published: March 2023

For several decades, among all possible pathogens of neonatal infections, group B streptococcus has been one of the leading positions. Sepsis, meningitis, and pneumonia are among the most common clinical manifestations of neonatal infection associated with group B streptococcus. In this review, our goal was to analyze the literature demonstrating a worldwide approach to the prevention of vertical transmission of group B streptococcus from mother to child. When writing the review, scientific publications of foreign and domestic authors from the PubMed database were studied. The review considers the drugs of choice for intranatal antibiotic prophylaxis, and their pharmacodynamic, and pharmacokinetic features. The analysis details the problem of the growth of resistance of group B streptococcus to antibacterial drugs. The antimicrobial activity of lactoferrin was noted at a minimum inhibitory concentration of 500 μg/ml. The presented review also reflects the protective and therapeutic effects of oral intake of probiotics containing Lactobacillus acidophilus, Lactobacillus salivarius, Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14 . Based on the analysis, it can be concluded that penicillin G and ampicillin have the most pronounced bactericidal effect against group B streptococcus. At the same time, the most common side effects of β-lactam penicillins include an allergic reaction with the possible development of anaphylactic shock. Given this, the antibiotics of the first-line reserve group include cefazolin, clindamycin, and vancomycin. At the same time, it is important to take into account the decrease in the therapeutic concentration of clindamycin with a change in the alpha-1-acid glycoprotein in the blood of the mother and fetus, the nephrotoxic effect of vancomycin and the cross-a llergic reaction of cefazolin with antibiotics of the penicillin group. A promising direction in solving the problem of group B streptococcus is the development of new strategies for the prevention of perinatal infection of the fetus and newborn based on a more detailed study of the effects of lactoferrin and probiotics.
Torah sebagai Kitab Suci Yudaisme: Konsep dan klasifikasi
Authors: Rizal Maulana Abdullah Muslich , Camila Marsha , Putri Meisin Imanda , Hafitzah Nabila , Sidqi Nailatu Lutfiyah
Published: March 2023

Scripture is one of the essential parts of every religion, as from scripture, people can understand many things related to the belief in question, such as the concept of divinity, teachings, rituals, laws and regulations, and many others. Likewise, Jews own Torah which was revealed to the prophet Moses. In addition, there are also other books that they believe in the life of Jews. This study aimed to determine the definition, meaning, and classification of Torah according to Judaism. Accordingly, this study used a descriptive analysis method through a qualitative approach with literature studies to sufficiently understand the intended research purpose. This study concluded that Torah is Jews guideline of life, containing divine laws taught to Moses and transmitted to further generations. Torah, in detail, encompasses five books: Bereshit, Shemot, Vayiqra, Bemidbar, and Devarim. ABSTRAKAgama yang diyakini setiap umat  memiliki Kitab Suci sebagai salah satu bagian penting dari setiap agama, oleh karena dari kitab suci orang dapat memahami banyak hal yang berkaitan dengan kepercayaan terkait, seperti konsep ketuhanan, ajaran, ritual, hukum dan peraturan, dan banyak lainnya. Pun demikian umat Yahudi juga memiliki Torah yang diturunkan kepada Musa. Selain Torah, ada juga kitab-kitab lain yang mereka yakini mendeskripsikan kehidupan orang Yahudi. Penelitian ini bertujuan untuk mengetahui definisi, makna, dan klasifikasi Torah menurut Yudaisme. Guna mencapai itu, penelitian ini menggunakan metode analisis deskriptif melalui pendekatan kualitatif dalam bentu studi pustaka untuk mampu menjawab tujuan penelitian yang dimaksud. Penelitian ini menyimpulkan bahwa Torah adalah pedoman hidup orang Yahudi, berisi hukum-hukum ketuhanan yang telah diajarkan kepada Musa dan diturunkan kepada generasi selanjutnya. Torah, secara detail mencakup lima kitab: Bereshit, Shemot, Vayiqra, Bemidbar, dan Devarim.
Kontroversi Jazbah dan Suluk dalam Tarekat Al-Naqsyabandiyah Al-Khalidiyah
Authors: Nur Faisal Muhammad
Published: March 2023

Jazbah and mysticism are part of the Islamic Shari'a and are also the spirit of the Islamic Shari'a to unite Allah SWT. The spiritual teachings of Jazbah and Sufi mysticism can be used as a solution to overcoming various kinds of problems in human life and can maintain harmony both internally and between religious communities, because the foundation of Sufi is love and compassion (mahabbah). This article belongs to literature research with a qualitative approach. The methodology used is a descriptive analysis study. The reference sources used are literacy references such as books and journals related to religious moderation. The results of the research in essence there is no controversy between fiqh scholars and tasawwuf scholars in the implementation of jazbah and mysticism in the Naqsyabandiyah order because that is one way to achieve the degree of ihsan.ABSTRAKJazbah dan suluk  merupakan bagian dari Syariát Islam dan juga merupakan ruh dari Syariát  Islam untuk meng-Esakan Allah Swt. Ajaran spiritual Jazbah dan suluk sufi dapat dijadikan sebagai solusi untuk menanggulangi berbagai macam problematika kehidupan manusia serta dapat menjaga kerukunan baik intern maupun antar ummat beragama, karena pondasi dari sufi adalah cinta dan kasih sayang (mahabbah). Artikel ini tergolong dalam penelitian pustaka dengan pendekatan kualitatif. Adapun metodologi yang digunakan adalah studi deskriptif analisis. Sumber rujukan yang digunakan adalah referensi literasi seperti buku dan jurnal terkait. Hasil penelitian pada hakekatnya tidak ada kontroversi antara ulama fiqih dengan ulama tasawuf dalam pelaksanaan jazbah dan suluk dalam tarekat Naqsyabandiyah sebab itu merupakan salah satu jalan untuk mencapai derajat ihsan.
Russia’s Arctic Strategy in the Greater Eurasian Partnership
Authors: Kefeli I. F. , Nikolaenko A. V.
Published: March 2023

This study focuses on the role of the Arctic Strategy of Russia in the Great Eurasian Partnership.Aim. The study aims to identify the features of the Arctic Strategy of Russia in the Great Eurasian Partnership.Tasks. The development of principles of geopolitical forecasting and work with big data, with the aim of synchronizing the integration processes contradictory in nature and interests of the actors in Greater Eurasia, identifying the features of the geopolitical regionalization of Eurasia, and analyzing the global security analytics of the Great Eurasian Partnership in the coming “digital era”.Methods. The transition from the “analog” to the “digital era” at the beginning of the 21st century meant an essentially revolution in the data itself, which was associated with the emergence of their new quality — predictive. The methodology for research and forecasting the prospects of Eurasian integration is modeling the multi-agent interaction of geopolitical factors of coalitions based on mathematical game theory. The strategy of transition to a polycentric world order implies the need to move from “geopolitical fiction” to geopolitics, based on mathematical modeling of global geopolitics processes using game theory methods.Results. The geopolitical regionalization of Eurasia is a challenge to time. On the expanses of the Eurasian continent, several multi-format long-term “Eurasian projects” are increasingly clearly emerging. This is, firstly, the Eurasian Economic Union, secondly, the Chinese One Belt-One Way and, thirdly, Indo-Pacifica. The Russian Arctic is a region of the Great Eurasian Partnership. The tasks of the modern Arctic policy of Russia are focused on ensuring the priority growth of raw materials exports and industrial development of the Arctic territories, rather than on solving the problems of improving the quality of life of the local population, although in the Russian Arctic strategy until 2035 these tasks are formulated quite correctly.Conclusion. The analytics of the Eurasian partnership and the wording of expert assessments should be formed on the basis not only of political discourse, but also of exact sciences. In modern conditions, the development of scenario projects for the construction of the Great Eurasian Partnership, which includes the Greater Arctic (which, in turn, require an independent theoretical and methodological study), involves the full use of the apparatus of mathematical geopolitics (game theory), scenario modeling and big data technologies.
The State and Prospects of the Study of Urbanization as an International Political Phenomenon
Authors: Sudants M. B.
Published: March 2023

The present study is aimed at studying urbanization as an international political phenomenon in modern world politics.Aim. To define the concept of urbanization and the city in modern political science and to identify the role of urbanization processes in international relations.Tasks. To define the essence of the city as a political concept, to define modern political concepts of cities, to comprehend the prospects of urbanization processes for modern international relations.Methods. In this paper, using the methods of analysis, synthesis and forecasting, the factors contributing to the influence of urbanization on modern international relations are identified.Results. The study showed that urbanization is an integral part of the international political process of the XXI century, the importance of which is increasing every year. Currently, the political, economic, and cultural life of society is concentrated in cities. At the same time, the number of urban residents is steadily increasing, which makes the XXI century the century of large urban settlements. Political practice shows that with increasing trends towards glocalization and regionalization, cities are becoming more and more autonomous players in solving local domestic and foreign policy issues, entering the world arena through special cross-border urban associations.Conclusion. The international legal non-regulation of the autonomy of cities as actors in international relations complicates the modern world political process. Nevertheless, global, and smart cities are becoming the flagships of urbanization and the centers of attraction for international cooperation, including in the field of politics, which makes it necessary to study them as a new international political phenomenon.
Kazakhstan’s Foreign Trade with EAEU Partners: Preliminary Results
Authors: Dodonov V. Y.
Published: March 2023

This study is aimed at identifying the preliminary results of Kazakhstan’s foreign trade with countries that have agreements on economic cooperation with the Eurasian Economic Union.Aim. Identification the emergence of effects for Kazakhstan’s foreign trade from agreements with the EAEU partner states.Tasks. Analyze the indicators of Kazakhstan’s foreign trade with states that have preferential modes of cooperation with the EAEU, compare these indicators of the validity period of the relevant agreements with previous periods and with the parameters of Kazakhstan’s foreign trade as a whole, assess the results of foreign trade during the period of validity of agreements on economic cooperation. Methods. In this work, we used the methods of time series analysis and comparative analysis.Results. The study showed that in most cases, the intensity of Kazakhstan’s mutual trade with countries that have preferential regimes of cooperation with the EAEU has significantly increased after the conclusion of agreements. Trade of Kazakhstan with the only country with a relatively long history of the current free trade agreement, Vietnam, showed significant growth during this period, many times higher than the general indicators of foreign trade. The outstripping growth in trade with the considered countries occurs, as a rule, due to an increase in Kazakhstani exports, which has a positive effect on foreign trade as a whole and has a positive effect on the indicators of the trade and balance of payments. The cumulative effect for Kazakhstan’s foreign trade from increasing trade with the EAEU partner countries is quite large and is measured by an annual increase in trade turnover at the level of more than $ 650 million, and an increase in exports in the amount of slightly less than $ 1 billion.Conclusion. The preliminary results of Kazakhstan’s foreign trade with the EAEU partner countries are positive and confirm the existence of potential for further cooperation through the conclusion of new trade and other agreements with other states.
Coordination of Economic and Defense Activities in the Pacific Region
Authors: Kozmenko S. Y.
Published: March 2023

Europe — Eurasia — Asia. Each continent of the vast continent corresponds to a dominant continental power, respectively Germany — Russia — China; in one of them (China), in the zone of conjugation of the Eurasian and Asian continental civilizations, that is, in the Russian-Chinese borderland, a new regional entity is emerging and developing with the attributes of a maritime civilization.Aim. The aim of the study is to solve the scientific problem of matching the national interests of the two countries within this regional maritime space.Tasks. To achieve the goal of the study, the following tasks are being solved: to substantiate the structure of the allocated geopolitical entity and to identify the directions of interaction between the two countries on the basis of coordinating economic and defense activities in the Pacific region.Methods. In this work, the methodological tools of spatial economics and the theory of new economic geography are used, which make it possible to combine geopolitical and economic (geoeconomic) imperatives in a localized space when coordinating joint activities. The core of this formation is the three seas of the Pacific basin adjacent to the territory of China. However, China’s strategic interests extend further, to the north, into the water area of at least two Russian seas. Thus, Russia is also involved in joint maritime activities within the Pacific region.Results. As a result, this creates a space of common national interests, which covers the waters of the five seas and adjacent territories. The regional core of this formation tends to expand, north, east and south, and further west, into the Indian Ocean.Conclusion. The conclusions of the study are that the maritime (more precisely, naval) activities of the two continental powers are essentially becoming the basis of cooperation and cooperation between Russia and China, since Russia can contribute to the implementation of China’s vast national interests only in the defense sphere, providing, in addition, significant, political support for China. As for economic activity, first of all, while meeting the growing demand of the Chinese economy for energy resources (oil, gas and coal), the prospects in this direction lie outside the current planning horizons (until 2035) when implementing large Arctic gas projects. in the water area of the Gulf of Ob “Arctic LNG 1, 2, 3”.
Classification of Maritime Disputes and Modern Legal Means of their Resolution
Authors: Kirilenko V. P. , Alekseev G. V.
Published: March 2023

A review of scientific articles published over the past 15 years in leading foreign scientific journals on international law demonstrates the gradual improvement of legal means for the settlement of maritime disputes between the states.Aim. Identification of the features for application of the law of the sea norms targeted on the resolution of maritime disputes that develop in the modern international system.Tasks. Development of the classification of maritime disputes, analysis of the jurisdiction of the judicial authorities competent to resolve maritime disputes, characterization of the provisions of international agreements and customs of the law of the sea in the resolution of maritime disputes by the International Court of Justice of the United Nations (ICJ), the International Tribunal for the Law of the Sea (ITLOS) and the Permanent Court of Arbitration in The Hague (PCA).Methods. Discourse analysis of the most authoritative publications on the issue of resolving maritime disputes, a formal legal analysis of the norms and customs of maritime law, as well as a comparative legal study of judicial and arbitration practice in resolving interstate maritime disputes. Law enforcement practice on maritime disputes allows to characterize the subject of modern interstate maritime disputes; critically assess the fairness of decisions of international courts; to analyze the problems of enforceability of judicial and arbitral awards in the framework of the procedures for the settlement of maritime disputes provided for in the 1982 UN Convention on the Law of the Sea.Results. Reasonable decisions of the International Court of Justice, the International Tribunal for the Law of the Sea and the Permanent Court of Arbitration in The Hague are usually implemented by the states parties to the 1982 UN Convention on the Law of the Sea. Protection of the marine environment as well as prompt release of ships and crews from arrest have become a modern legal reality due to the effectiveness of the legal mechanism for resolving interstate maritime disputes. Territorial maritime disputes cause significant difficulties at all stages of their resolution, which is due to their political nature and the efforts of states to protect their national interests.Conclusion. The resolution of maritime territorial disputes requires more flexibility from the parties, an international agreement between the parties to the dispute on the procedure for its consideration, as well as the use of conciliation procedures to work out a compromise solution to the dispute.
Ideas and Realities of Contemporary Eurasianism
Authors: Glazyev S. Y.
Published: March 2023

.
Do Quantitative Levels of Anti-Spike-IgG Antibodies Aid in Predicting Protection from SARS-CoV-2 Infection? Results from a Longitudinal Study in a Police Cohort
Authors: Sendi Parham , Widmer Nadja , Branca Mattia , Thierstein Marc , Büchi Annina Elisabeth , Güntensperger Dominik , Blum Manuel Raphael , Baldan Rossella , Tinguely Caroline , Heg Dik , Theel Elitza S. , Berbari Elie , Tande Aaron J , Endimiani Andrea , Gowland Peter , Niederhauser Christoph
Published: March 2023

Objectives In a COVID-19 sero-surveillance cohort study with
predominantly healthy and vaccinated individuals, the objectives were
(i) to investigate longitudinally the factors associated with the
quantitative dynamics of anti-spike IgG antibody levels, (ii) to
evaluate whether the antibody levels were associated with protection
from SARS-CoV-2 infection and (iii) to assess whether the association
was different in the pre-Omicron compared with the Omicron period.
Methods The QuantiVac Euroimmun ELISA test was used to quantify
anti-S1 IgG levels. The entire study period (16 months), the 11-month
pre-Omicron period and the cross-sectional analysis prior to the Omicron
surge included 3219, 2310 and 895 reactive serum samples from 949, 919
and 895 study participants, respectively. Mixed-effect linear,
mixed-effect time-to-event and logistic regression models were used to
achieve the objectives. Results Age and time since infection or
vaccination were the only factors associated with a decline of anti-S1
IgG levels. Antibody levels were significantly associated with
protection from SARS-CoV-2 infection, and the association was higher for
the Omicron than for the Alpha and Delta variants. In a prediction
model, it was estimated that >8000 BAU/mL anti-S1 IgG was
required to reduce the risk of infection with Omicron variants by 20%
to 30% for 90 days. Conclusions Anti-S1 IgG antibody levels
are associated with protection from infection. The levels in the
pre-Omicron periods were less significant than during the Omicron surge,
which in turn required very high levels for protection in a statistical
model.
Calculation of the strength of reinforced concrete beams strengthened with composite materials
Authors: BORYSIUK Oleksandr , TRACH Roman
Published: March 2023

Currently, in view of the previous theoretical and experimental researches, the regulatory documents for the calculation of reinforced concrete elements strengthened by composite materials and the calculation and design of fiber reinforced concrete structures are in force in Ukraine and in the world. Simultaneous strengthening of the compressed and tensile zones has not been sufficiently studied. Therefore, further research of reinforced concrete elements, strengthened by modern and highly efficient materials, such as steel fiber concrete and composite materials, is of great theoretical and practical importance. The urgency of the study is due to the obvious need to improve the method of calculation of the reinforced concrete bending elements after simultaneously strengthening compressed and tensile zones.
On some convex combinations of biholomorphic mappings in several complex variables
Authors: Grigoriciuc Eduard
Published: March 2023

In this paper, our interest is devoted to study the convex combinations of
the form (1 ? ?) f + ?1, where ? ? (0, 1), of biholomorphic mappings on the
Euclidean unit ball Bn in the case of several complex variables. Starting
from a result proved by S. Trimble [26] and then extended by P.N. Chichra
and R. Singh [3, Theorem 2] which says that if f is starlike such that Re[f
?(z)] > 0, then (1??)z+?f (z) is also starlike, we are interested to extend
this result to higher dimensions. In the first part of the paper, we
construct starlike convex combinations using the identity mapping on Bn and
some particular starlike mappings on Bn. In the second part of the paper, we
define the class L* ?(Bn) and prove results involving convex combinations of
normalized locally biholomorphic mappings and Loewner chains. Finally, we
propose a conjecture that generalize the result proved by Chichra and Singh.
Regularized asymptotics of the solution of systems of parabolic differential equations
Authors: Omuraliev Asan , Abylaeva Ella
Published: March 2023

The regularization method for singularly perturbed problems of S. A. Lomov is
generalized to constructing the asymptotics of the solution of the first
boundary value problem for systems of differential equations of parabolic
type with a small parameter at all derivatives.It is shown that the
asymptotics of the solution of the problem contains n exponential, 2n
parabolic and 2n angle boundary layer functions. The exponential boundary
layer function describes the boundary layer along t = 0, the boundary layer
along x = 0 and x = 1 is described by parabolic boundary layer functions.
Two theorems involving cyclic generalized proximal C-contractive non-self mappings
Authors: Ayari Iadh , Aydi Hassen , Hammad Hasanen , Imdad M.
Published: March 2023

This paper explores certain best proximity point expansions for a novel class
of non-self-mapping S : P ? Q and T : Q ? P called generalized proximal
C-contractions of the first and second kinds. We expose many examples to
justify our obtained results. Considerable fixed point results are evolved
as a consequence of our main theorems.
Cardiovascular safety in type 2 diabetes with sulfonylureas as second-line drugs: a nation-wide population based comparative safety study
Authors: WANG HUAN , Cordiner Ruth L. M. , Huang Yu , Donnelly Louise , Hapca Simona , Collier Andrew , McKnight John , Kennon Brian , Gibb Fraser , McKeigue Paul , Wild Sarah H , Colhoun Helen , Chalmers John , Petrie John , Sattar Naveed , MacDonald Thomas , McCrimmon Rory J , R. Morales Daniel , R. Pearson Ewan , Group the Scottish Diabetes Research Network Epidemiology
Published: March 2023

  

Objective

To assess the real-world cardiovascular (CV) safety for SU, in comparison with dipeptidylpeptidase-4 inhibitors (DPP4i) and thiazolidinediones (TZD) through development of robust methodology for causal inference in a whole nation study. 

Research Design and Methods

A cohort study was performed including people with type 2 diabetes diagnosed in Scotland before 31 December 2017, who failed to reach HbA1c 48 mmol/mol despite metformin monotherapy and initiated second-line pharmacotherapy (SU/DPP4i/TZD) on or after 1 January 2010.

The primary outcome was the composite major adverse cardiovascular events (MACE), including hospitalization for myocardial infarction (MI), ischemic stroke, heart failure, and CV death. Secondary outcomes were each individual endpoint and all-cause death. Multivariable Cox proportional hazards regression and an instrumental variable (IV) approach were used to control confounding in a similar way to the randomization process in a randomized control trial.  

Results

Comparing SU to non-SU (DPP4i/TZD), the hazard ratio (HR) for MACE was 1.00 (95% CI: 0.91 to 1.09) from the multivariable Cox regression and 1.02 (0.91  - 1.13) and 1.03 (0.91- 1.16) using two different IVs. For all-cause death, the HR from Cox regression and the two IV analyses was 1.03 (0.94 - 1.13), 1.04 (0.93 - 1.17), and 1.03 (0.90 - 1.17). 

Conclusion

Our findings contribute to the understanding that second-line SU for glucose lowering are unlikely to increase CV risk or all-cause mortality. Given their potent efficacy, microvascular benefits, cost effectiveness and widespread use, this study supports that SU should remain a part of the global diabetes treatment portfolio.Article  
Rapid Decline in Beta-Cell Function and Increasing Adiposity is Associated with Conversion to Type 2 Diabetes in at Risk Latino Youth
Authors: Vidmar Alaina P. , Durazo-Arvizu Ramon , Weigensberg Marc J. , Alderete Tanya L. , Goran Michael I.
Published: March 2023

  

Youth onset type 2 diabetes (T2D) is becoming increasingly prevalent especially among Latinos, and there is limited information on its pathophysiology and causative factors. Here we describe findings from a longitudinal cohort study in 262 Latino children with overweight/obesity at risk of developing T2D with annual measures of oral and intravenous glucose tolerance (IVGTT), body composition and fat distribution.  Logistic binomial regression was used to identify significant predictors in those who developed T2D compared to matched controls, and mixed-effects growth models to compare rates of change in metabolic versus adiposity measures between groups. Overall conversion rate to T2D at year five was 2% (n=6). Rate of decline in disposition index (DI), measured with an IVGTT, over 5 years was 3X higher in cases (─341.7 units/year) compared to the extended cohort (‒106.7 units/year) and 20X higher compared to controls (‒15.2 units/year). Cases had a significantly higher annual increase in fasting glucose, hemoglobin A1c, waist circumference, and trunk fat and there was an inverse correlation between rate of decline in DI and rate of increase in adiposity measures. T2D development in at risk Latino youth is associated with a substantial and rapid decrease in DI that is directly correlated with increase in fasting glucose, HbA1c, and adiposity. 
Increased Economic Crime in the Housing and Utilities Sector: Reasons and Ways to Overcome Them
Authors: Bidova B. B. , Bystrova Yu. V. , Grib V. G.
Published: March 2023

Introduction. The housing and utilities sector is an integral part of the national economy affecting absolutely all citizens of Russia. In recent years, the number of economic crimes committed in this sector has increased. Bringing down the level of crime, developing the crime preventive measures in this sector constitute the scientific interest and relevance of the study. The purpose of the study is to analyse the reasons of increased economic crime in the sector of housing and utilities (hereinafter — housing and utilities), as well as to develop theoretical and practical recommendations aimed at decreasing the level of crime in this sector.Materials and Methods. To achieve the set forth goal, the general scientific dialectical method of cognition was used, the methods of analysis and synthesis used for generalising theoretical and practical material, the empirical and statistical methods made it possible to draw the main conclusion of the study and achieve the goal.Results. A comprehensive and multifaceted approach to solving the problem of increased economic crime in the housing and utilities sector has been implemented from perspective of criminal law, criminal-procedural and criminological scientific knowledge. The scientific value of this study is gained due to the comprehensive review of the reasons in the context of the overall picture of economic criminality in housing and utilities sector which allows making the most complete conclusions and defining general and specific criminological measures for preventing crime in the housing and utilities sector, namely, general social, economic, organisational and legal and educational measures; the specific ones carried out by the state housing supervision authorities and the internal affairs authorities.Discussion and Conclusions. The analysis of the judicial and investigative materials made it possible to identify the reasons of increased economic crime in the housing and utilities sector, as well as to develop efficient preventive measures to combat such crime. The article provides recommendations for practicing specialists (investigators of the economic crimes in the housing and utilities sector; judges hearing and passing sentences in this category of cases; employees of administrative offices calculating and setting the rates and resource-supplying companies charging the utility payments), as well as for researchers in the field of criminal law sciences.
PROFIL CAREER ANCHOR DAN IMPLIKASINYA PADA MOTIVASI KERJA APARATUR SIPIL NEGARA
Authors: Nurmala Sukma , Megawati Yunda
Published: March 2023

Penelitian ini bertujuan untuk melihat profil career anchor di tempat kerja, khususnya dalam organisasi birokrasi, serta implikasinya pada motivasi kerja aparatur sipil negara (ASN) yang bekerja di Direktorat Jenderal Otonomi Daerah Kementerian Dalam Negeri (Ditjen Otda Kemendagri). Metode penelitian ini menggunakan pendekatan kuantitatif korelasional untuk melihat pengaruh variabel x (career anchor) terhadap variabel y (motivasi kerja). Instrumen penelitian yang digunakan meliputi skala career anchor inventory (CAI) yang dikembangkan oleh Igbaria dan Baroudi (1993) dalam Meiliani & Budiarto (2008) dan skala The Multidimensional Work Motivation Scale (MWMS) yang disusun oleh Gagné dkk. (2015). Jumlah partisipan dalam penelitian sebanyak 104 orang. Data yang diperoleh selanjutnya dianalisis menggunakan teknik regresi sederhana menggunakan software SPSS. Hasil penelitian ini menunjukkan bahwa variabel career anchor berpengaruh terhadap variabel motivasi kerja sebesar b=.495 (Sig.=.000<.05, effect size 24.3%, = 0.243, Fhitung=32.662). Koefisien determinasi pengaruh career anchor terhadap motivasi kerja sebesar 0,243. Hal tersebut dapat diinterpretasikan bahwa variabel career anchor memiliki peran terhadap variabel work motivation sebesar 24,3%, sedangkan  sisanya sebesar 75,7% dipengaruhi oleh faktor yang lain. Temuan lainnya menunjukkan bahwa profil career anchor yaitu pure challenge (thitung = 4.037) berpengaruh dominan terhadap motivasi kerja pegawai ASN di Ditjen Otda Kemendagri. Temuan ini menegaskan bahwa motivasi kerja mayoritas pegawai dipengaruhi oleh tantangan untuk menyelesaikan permasalahan yang terjadi di lingkungan kerjanya dan didukung juga oleh adanya situasi kerja yang kompetitif.
The Interrelations of Nature and Woman in Takahata's The Tale of The Princess Kaguya: An Ecofeminist Perspective
Authors: Tandayu Lalita , Wijanarka Hirmawan
Published: March 2023

Nature, as an essential part of human life, should be preserved to maintain a good quality of life for living beings, and literature can be a tool to promote this issue. This article aims at (1) exploring the characters in Isao Takahata's The Tale of the Princess Kaguya and (2) analyzing the interrelations of woman and nature as parallel in a patriarchal society. In discussing the movie, this article employs the ecofeminist approach. Five theories are applied to support the analysis: the theory of characterization and Mise en Scène, the theory of ecofeminism, the theory of symbolism, and the theory of patriarchy. The Tale of the Princess Kaguya reveals the equation of women and nature and how both are devalued. The analysis of the characters reveals that Princess Kaguya possesses caring, adventurous, and mysterious characteristics, while Sanuki no Miyatsuko possesses caring, loving, ambitious, and arrogant characteristics. The analysis also finds that Princess Kaguya loves to play with nature. She is equated to an animal, such as a bird, and a plant which is a tree branch. Women and nature are seen as parallel in the story. On the other hand, the noblemen in the story, as the masculine, are ignorant of nature as they pluck flowers and destroy a swallow's nest. This study finds out that Princess Kaguya experiences oppression as she is forced into a lifestyle she does not wish for and is harassed by an Emperor.
ESP and Business English for Postgraduate Students in the Department of Economics, Tahri Mohamed University, Bechar, Algeria
Authors: Khadam Gouabi
Published: March 2023

To bridge the gap between the ongoing demands of the fieldwork and the outcomes of the actual teaching, all the Algerian universities, with all the kinds of specialties they provide, embrace the learning of English for more specialized purposes and try to deliver curricula that maintain the balance between the two sides. The teaching of such a technical language for the postgraduate students presents a challenge for ESP practitioners since they are asked to submit an overall knowledge of the language alongside particular business English needed to accomplish a variety of tasks that are required from the students in the academic spheres or the professional settings. Most of these ESP practitioners are general language teachers and are asked to cover the growing needs of their learners in their fields of specialty. However, this current teaching situation reveals several serious obstacles which prevent the teaching outcomes from reaching their goals. Even though most of the literature review devoted to Business English teaching focused on the professional demands to maintain the specialized registers, the current investigations show that the presented ESP sessions are still twining with general English ones and deprived of reaching the postgraduate students’ academic as well as professional desires. Moreover, the study uses a case study of eighteen first year doctorate students at Tahri Mohamed university, Bechar, Algeria to investigate the research. The data collected was analyzed quantitatively and qualitatively through a delivered questionnaire and a semi-structured interview given to the teacher so as to present his views about the teaching situation. The analysis of the collected data allowed the researcher to claim that the ESP courses presented in these classes are not satisfactory since they do not meet the learners requirements and thus, suggest a number of interesting recommendations that may help in the improvement of the teaching/learning situations. As a result, the current study is done with the purpose to shed light on the teaching/learning situation and then providing a profile of the specific target needs of these researchers, which helps while designing a suitable syllabus appropriate to their special fields of interest.
Test Control of English Grammatical and Lexical Competencies of Secondary School Pupils in Ukraine
Authors: Ponomarenko Nataliia , Smuhliakova Maryna , Mochalova Nataliia , Fomichovaq Valeriia
Published: March 2023

The article is dedicated to the test control of English grammatical and lexical competencies of secondary school pupils (five-grade). The study examined the nature and structure of the concepts of “control,” “test” and “test control.” This scientific research aims to investigate the features of the designed exercises for monitoring the formation of the English competencies of pupils of the middle level mentioned above. The significance of the study is determined by the focus of modern linguistics and pedagogics on identifying the features of the methodological control of the formation of English grammatical and lexical evaluation of five-grade school pupils. The main question of the research is how testing control can ensure the successful implementation of the purpose and all functions of control, as well as meet the requirements for its quality. The conditions for the effective use of the mentioned methods in controlling the competence in grammar and lexicon of five-grade school pupils are determined. The Physiological features of students and their psychological readiness for tests were revealed. Methodological analysis was made for the choice of exercises or activities to check for grammar and vocabulary of pupils of the fifth grade. Experimental verification of exercises is designed to check for grammatical and lexical competence of five-grade pupils. To control and evaluate the knowledge and skills of the pupils, at the end of the pedagogical experiment, we held a kind of control competition between the experimental and control grades, for the implementation of which the test tasks were thought out.
Optimal Maternal-Fetal Interface Environment Affects Neonatal Viability in Preterm Preeclampsia and IUGR Pregnancy
Authors:   Bhayangkara Tk.I R. Said Sukanto Police Hospital Jakarta, Resistantie Novi , Semuel Semuel , Roviqo Cindy Fawwaz , Ramdani Taufik
Published: March 2023

Objective: to report rare case of fetal viability on preterm pregnancy with preeclampsia and IUGR Methods: case report Case: A 29-year-old woman (G1P0A0) at 29 weeks of gestation, came to the Obstetrics and Gynecology Outpatient Clinic of Bhayangkara Tk. I R. Said Sukanto Police Hospital Jakarta with complaints of left-sided headache since 25 weeks of gestation. After examination, the patient was diagnosed with preeclampsia with IUGR. The caesaria section was performed at 28 weeks and a baby was born with BW: 850 grams, BL: 31 cm, and an APGAR score of 5/6. No inflammatory cells were found in chorionic villi. The baby continues to live after being treated in the NICU for 30 days. Conclusion: Optimal maternal fetal interface environment secures neonatal viability. Lingkungan Antarmuka Maternal-Fetal yang Optimal Mempengaruhi Kelangsungan Hidup Neonatal pada Kehamilan Prematur dengan Preeklamsia dan IUGR Abstrak Tujuan: untuk melaporkan kasus jarang viabilitas fetus pada kehamilan preterm dengan preeklampsia dan IUGR Metode: laporan kasus Kasus: Seorang perempuan berusia 29 tahun (G1P0A0) dengan usia kehamilan 29 minggu, datang ke Poliklinik Obstetri dan Ginekologi Rumah Sakit Bhayangkara Tk. I R. Said Sukanto Jakarta mengalami pusing pada kepala sebelah kiri sejak usia kehamilan 25 minggu. Setelah pemeriksaan, pasien didiagnosa mengalami preeklamsia dengan perburukan IUGR. Operasi Seksio sesarea dilakukan pada usia kehamilan 28 minggu dan lahir seorang bayi dengan BB: 850 gram, PB: 31 cm, dan skor APGAR 5/6. Tidak ditemukan sel yang mengalami inflamasi pada vili chorionic. Bayi tetap hidup setelah dirawat di NICU selama 30 hari. Kesimpulan: Interaksi maternal fetal yang optimal menjamin viabilitas fetus. Kata kunci: Inflamasi, IUGR, Preeklamsia, Viabilitas Fetus, Preeklamsia.
The Role of Vitamin D and Vitamin D Receptor in Placenta Accreta Spectrum: A Literature Review
Authors:   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital/Faculty of Medicine Sriwijaya University, Palembang, South Sumatera, Mirani Putri , Lestari Peby Maulina , Murti Krisna , Liberty Iche Andriyani , Kesty Cindy , Andrina Hana , Stevanny Bella
Published: March 2023

Objective: This study aims to review the role of vitamin D and vitamin D receptor in Placenta Accreta Spectrum Disorder (PASD) Method: This review used several databases, namely Google Scholar, Science Direct, Elsevier, Medline, PubMed, Proquest, dan Wiley Online Library to search original and review articles in English about placenta accreta spectrum, placenta accreta, vitamin D, and vitamin D receptor in the last 10 years. Other reference sources used were guidelines and textbooks. Results: A total of four articles were included in this review. Discussion: Placenta accreta spectrum disorder is becoming more common around the world, owing to the rise in cesarean deliveries. It is linked to several risk factors, including a lack of vitamin D. Vitamin D and its receptor stimulate endometrial decidualization, which aids implantation. Vitamin D receptors in human placental trophoblasts create and respond to 1,25(OH)2D3, which promotes the conversion of endometrial cells to decidual cells. Women with PASD are mostly suffering from vitamin D deficiency. Conclusion: Vitamin D levels may influence trophoblast invasion in PASD and can be a potential diagnostic marker. Peran Vitamin D dan Reseptor Vitamin D dalam Spektrum Plasenta Akreta: Suatu Tinjauan Pustaka Abstrak Tujuan: Penelitian ini bertujuan untuk meninjau peran vitamin D dan reseptor vitamin D dalam Spektrum Plasenta Akreta (SPA) Metode: Tinjauan pustaka ini menggunakan beberapa sumber data yaitu Google Scholar, Science Direct, Elsevier, Medline, PubMed, Proquest, dan Wiley Online Library untuk mencari artikel penelitian dan tinjauan pustaka dalam Bahasa Inggris mengenai plasenta akreta, vitamin D, dan reseptor vitamin D dalam 10 tahun terakhir. Sumber referensi lain yang digunakan adalah pedoman dan buku teks. Hasil: Sebanyak empat artikel dimasukkan dalam ulasan ini. Diskusi: Spektrum Plasenta Akreta terjadi lebih sering di seluruh dunia karena meningkatnya persalinan sesar. Plasenta akreta terkait dengan beberapa faktor risiko termasuk kekurangan vitamin D. Vitamin D dan reseptornya merangsang desidualisasi endometrium dan berperan dalam implantasi. Reseptor vitamin D pada trofoblas plasenta membuat dan merespons 1,25(OH)2D3 yang mendorong konversi sel endometrium menjadi sel desidua. Mayoritas wanita dengan SPA mengalami kekurangan vitamin D. Kesimpulan: Kadar vitamin D dapat mempengaruhi invasi trofoblas pada SPA dan berpotensi menjadi penanda diagnostik. Kata kunci: spektrum plasenta akreta, reseptor vitamin D, vitamin D