bluuebunny/crossref_metadata_2025 huggingface dataset:
Advances in Current Diabetes Proteomics: From the Perspectives of Label- free Quantification and Biomarker Selection
Authors: Fu Jianbo , Luo Yongchao , Mou Minjie , Zhang Hongning , Tang Jing , Wang Yunxia , Zhu Feng
Published: August 2019

Background:

Due to its prevalence and negative impacts on both the economy and society, the diabetes mellitus (DM) has emerged as a worldwide concern. In light of this, the label-free quantification (LFQ) proteomics and diabetic marker selection methods have been applied to elucidate the underlying mechanisms associated with insulin resistance, explore novel protein biomarkers, and discover innovative therapeutic protein targets.

Objective:

The purpose of this manuscript is to review and analyze the recent computational advances and development of label-free quantification and diabetic marker selection in diabetes proteomics.

Methods:

Web of Science database, PubMed database and Google Scholar were utilized for searching label-free quantification, computational advances, feature selection and diabetes proteomics.

Results:

In this study, we systematically review the computational advances of label-free quantification and diabetic marker selection methods which were applied to get the understanding of DM pathological mechanisms. Firstly, different popular quantification measurements and proteomic quantification software tools which have been applied to the diabetes studies are comprehensively discussed. Secondly, a number of popular manipulation methods including transformation, pretreatment (centering, scaling, and normalization), missing value imputation methods and a variety of popular feature selection techniques applied to diabetes proteomic data are overviewed with objective evaluation on their advantages and disadvantages. Finally, the guidelines for the efficient use of the computationbased LFQ technology and feature selection methods in diabetes proteomics are proposed.

Conclusion:

In summary, this review provides guidelines for researchers who will engage in proteomics biomarker discovery and by properly applying these proteomic computational advances, more reliable therapeutic targets will be found in the field of diabetes mellitus.
Targeting Cancer Stem Cells Pathways for the Effective Treatment of Cancer
Authors: Dwivedi Ashish Ranjan , Thakur Amandeep , Kumar Vijay , Skvortsova Ira , Kumar Vinod
Published: August 2019

Resistance to chemotherapy and relapse are major hurdles for the effective treatment of
cancer. Major reason for this is a small sub population of cancer stem cells (CSCs) and its microenvironment.
CSCs are critical driving force for several types of cancer, such as gastric, colon, breast and
many more. Hence, for the complete eradication of cancer, it is necessary to develop therapeutic approaches
that can specifically target CSCs. Chemical agents that target different proteins involved in
CSC signaling pathways, either as single agent or simultaneously targeting two or more proteins have
generated promising pre-clinical and clinical results. In the current review article, we have discussed
various targets and cellular pathways that can be explored for the effective and complete eradication
of CSCs. Some latest developments in the field of design, synthesis and screening of ligands to target
cancer stem cells have been summarized in the current review article.
Effectiveness of Post-Mortem Computed Tomography (PMCT) in Comparison with Conventional Autopsy: A Systematic Review
Authors: Uthandi Deveshini , Sabarudin Akmal , Mohd Zanariah , Rahman Mohd Amiruddin Abd , Karim Muhammad Khalis Abdul
Published: August 2019

Background:

With the advancement of technology, Computed Tomography (CT) scan
imaging can be used to gain deeper insight into the cause of death.

Aims:

The purpose of this study was to perform a systematic review of the efficacy of Post-
Mortem Computed Tomography (PMCT) scan compared with the conventional autopsies gleaned
from literature published in English between the year 2009 and 2016.

Methodology:

A literature search was conducted on three databases, namely PubMed, MEDLINE,
and Scopus. A total of 387 articles were retrieved, but only 21 studies were accepted after meeting
the review criteria. Data, such as the number of victims, the number of radiologists and forensic
pathologists involved, causes of death, and additional and missed diagnoses in PMCT scans were
tabulated and analysed by two independent reviewers.

Results:

Compared with the conventional autopsy, the accuracy of PMCT scans in detecting injuries
and causes of death was observed to range between 20% and 80%. The analysis also showed
that PMCT had more advantages in detecting fractures, fluid in airways, gas in internal organs,
major hemorrhages, fatty liver, stones, and bullet fragments. Despite its benefits, PMCT could
also miss certain important lesions in a certain region such as cardiovascular injuries and minor
vascular injuries.

Conclusion:

This systematic review suggests that PMCT can replace most of the conventional
autopsies in specific cases and is also a good complementary tool in most cases.
Monolinguals and Bilinguals Differ in Performance on the Taboo Stroop Task
Authors: Okada Kayoko , He Grace , Gonzales Alisa
Published: August 2019

Background:

Decades of research investigating cognitive performance differences between bilinguals and monolinguals suggest that these two populations differ in executive functioning. Studies have found that bilinguals often outperform monolinguals in a variety of Executive Function (EF) tasks. However, recent reviews of the literature suggest that the bilingual advantages previously reported may be overstated, particularly when linguistic materials are used in the study.

Methods:

The present study examined differences in cognitive inhibition using emotionally charging words in a taboo Stroop task. Monolingual and bilingual native English speakers were recruited for the study. The Stroop task consisted of half neutral words and half taboo (emotional) words used in previously published studies.

Results and Conclusion:

Consistent with previous research, we found that participants were slower to respond to taboo words, and these words were better recalled than neutral words. Contrary to our initial prediction of a bilingual speed advantage, bilinguals had slower response times compared to monolingual participants. Our results lend support to the growing body of research that bilingualism does not enhance domain-general executive functioning.
Application of fraud pentagon in detecting financial statement fraud
Authors: Antawirya R. Daniel Eka Prasetya , Putri I Gusti Ayu Made Dwija , Wirajaya I Gde Ary , Suaryana I Gusti Ngurah Agung , Suprasto Herkulanus Bambang
Published: August 2019

Financial statements manipulation was a fraud form which is generally difficult to detect. The study was intended to analyze fraud pentagon elements in detecting fraudulent financial statements. The research population was all financial sector companies listed on the Indonesia Stock Exchange for the 2015-2018 period. Purposive sampling technique was used to determine the research sample and data analysis techniques used multiple regression. Based on the test results, it shows the financial set has a positive positive effect on fraudulent financial statements and the number of audit committee meetings that reflect effectiveness has a negative effect on fraudulent financial statements. The study results also contribute to the fraud pentagon theory and provide evidence that elements on fraud pentagon model can be used to detect fraudulent financial statements.
An Assessment of Physical Activity Data Collected via a Smartphone App and a Smart Band in Breast Cancer Survivors: Observational Study
Authors: Chung Il Yong , Jung Miyeon , Lee Sae Byul , Lee Jong Won , Park Yu Rang , Cho Daegon , Chung Haekwon , Youn Soyoung , Min Yul Ha , Park Hye Jin , Lee Minsun , Chung Seockhoon , Son Byung Ho , Ahn Sei-Hyun
Published: August 2019

Background

Although distress screening is crucial for cancer survivors, it is not easy for clinicians to recognize distress. Physical activity (PA) data collected by mobile devices such as smart bands and smartphone apps have the potential to be used to screen distress in breast cancer survivors.

Objective

The aim of this study was to assess data collection rates of smartphone apps and smart bands in terms of PA data, investigate the correlation between PA data from mobile devices and distress-related questionnaires from smartphone apps, and demonstrate factors associated with data collection with smart bands and smartphone apps in breast cancer survivors.

Methods

In this prospective observational study, patients who underwent surgery for breast cancer at Asan Medical Center, Seoul, Republic of Korea, between June 2017 and March 2018 were enrolled and asked to use both a smartphone app and smart band for 6 months. The overall compliance rates of the daily PA data collection via the smartphone walking apps and wearable smart bands were analyzed in a within-subject manner. The longitudinal daily collection rates were calculated to examine the dropout pattern. We also performed multivariate linear regression analysis to examine factors associated with compliance with daily collection. Finally, we tested the correlation between the count of daily average steps and distress level using Pearson correlation analysis.

Results

A total of 160 female patients who underwent breast cancer surgeries were enrolled. The overall compliance rates for using a smartphone app and smart bands were 88.0% (24,224/27,513) and 52.5% (14,431/27,513), respectively. The longitudinal compliance rate for smartphone apps was 77.8% at day 180, while the longitudinal compliance rate for smart bands rapidly decreased over time, reaching 17.5% at day 180. Subjects who were young, with other comorbidities, or receiving antihormonal therapy or targeted therapy showed significantly higher compliance rates to the smartphone app. However, no factor was associated with the compliance rate to the smart band. In terms of the correlation between the count of daily steps and distress level, step counts collected via smart band showed a significant correlation with distress level.

Conclusions

Smartphone apps or smart bands are feasible tools to collect data on the physical activity of breast cancer survivors. PA data from mobile devices are correlated with participants’ distress data, which suggests the potential role of mobile devices in the management of distress in breast cancer survivors.

Trial Registration

ClinicalTrials.gov NCT03072966; https://clinicaltrials.gov/ct2/show/NCT03072966
Feasibility and Acceptability of an Interactive Mental Well-Being Intervention for People With Intellectual Disabilities: Pilot Mixed Methods Study
Authors: Vereenooghe Leen , Westermann Kristian
Published: August 2019

Background

The availability of both digital and traditional mental well-being interventions is rising, but these interventions typically do not consider people with intellectual disabilities as potential users.

Objective

The study aimed to explore the acceptability and feasibility of a new digital intervention, developed with and for people with intellectual disabilities, to improve their subjective well-being.

Methods

Using a single-group pre-post design, participants with intellectual disabilities and their caregivers completed the 4-week intervention. Mixed methods questionnaires assessed the acceptability of the intervention, in addition to self-report and proxy-report measures of subjective well-being and behavioral problems.

Results

A total of 12 men with mild to moderate intellectual disabilities enrolled in and completed the study alongside 8 caregivers. Participant acceptability of the intervention was high, and feedback covered multiple aspects of the intervention, including (1) program concept and design, (2) program content, and (3) intervention usage. Self-rated mood barometers indicated mood improvements for 5 participants, deteriorations for 2 participants, and no observed changes for the remaining participants. Statistical analyses yielded no difference from pretest (median=79; range 39-86) to posttest (median=79; range 21-96) for subjective well-being in people with intellectual disabilities (W=10.5; P=.17) and for behavioral problems (W=14; P=.05).

Conclusions

People with intellectual disabilities and their caregivers are receptive to using digital well-being interventions, and this research shows such interventions to be feasible in routine practice. Given the acceptability of the intervention, its potential efficacy can now be evaluated in people with intellectual disabilities and symptoms of reduced mental well-being.
Integrated Care Delivery for HIV Prevention and Treatment in Adolescent Girls and Young Women in Zambia: Protocol for a Cluster-Randomized Controlled Trial
Authors: Subramanian Sujha , Edwards Patrick , Roberts Sarah T , Musheke Maurice , Mbizvo Michael
Published: August 2019

Background

Among countries in sub-Saharan Africa, Zambia has one of the highest incidences of HIV. Adolescent girls and young women (AGYW) are a particularly affected group because of their social and economic vulnerability.

Objective

The goal of this study is to test a multilevel package of interventions at the community and health system levels in Zambia in order to connect AGYW with a source of regular care, which will in turn allow for sustainable, successful implementation of regular HIV testing and adherence to antiretroviral treatment.

Methods

We will adapt prior tools to create the SHIELD (Support for HIV Integrated Education, Linkages to Care, and Destigmatization) intervention to educate and empower Zambian AGYW of 10-24 years of age and their families and to create community-based youth clubs to foster peer support. We will also develop integrated wellness care clinics to offer a youth-friendly environment that provides tailored clinical services. We will perform formative research, including focus groups and in-depth interviews, among AGYW, caregivers, and stakeholders to help inform the development and tailoring of the interventions. A cluster-randomized controlled trial will be implemented in Lusaka, with six clinic catchment areas randomized into three groups: zones with integrated wellness care clinics and SHIELD intervention, zones with only SHIELD intervention, and control zones with no intervention. We will assess HIV testing among the HIV-negative or unknown (HIV-/u) cohort, and retention in care along with viral load suppression will be evaluated in the HIV-positive (HIV+) cohort. We will use in-depth interviews and surveys to collect staff and stakeholder feedback after the trial. Cost-effectiveness of the interventions and return-on-investment impacts will be quantified using a microsimulation model.

Results

Interim results are expected in 2021, and the final results are expected in 2022. If this multilevel intervention is successful in establishing a comprehensive care continuum for HIV-affected AGYW, the Zambian Ministry of Health may advocate for expansion to additional settings to support national scale-up.

Conclusions

This integrated service delivery model can also be a platform to implement additional preventive services, so HIV-/u and HIV+ AGYW can receive comprehensive, integrated services.

Trial Registration

ClinicalTrials.gov NCT03995953; https://clinicaltrials.gov/ct2/show/NCT03995953

International Registered Report Identifier (IRRID)

PRR1-10.2196/15314
Improving Medication Information Presentation Through Interactive Visualization in Mobile Apps: Human Factors Design (Preprint)
Authors: Roosan Don , Li Yan , Law Anandi , Truong Huy , Karim Mazharul , Chok Jay , Roosan Moom
Published: August 2019

BACKGROUND

Despite the detailed patient package inserts (PPIs) with prescription drugs that communicate crucial information about safety, there is a critical gap between patient understanding and the knowledge presented. As a result, patients may suffer from adverse events. We propose using human factors design methodologies such as hierarchical task analysis (HTA) and interactive visualization to bridge this gap. We hypothesize that an innovative mobile app employing human factors design with an interactive visualization can deliver PPI information aligned with patients’ information processing heuristics. Such an app may help patients gain an improved overall knowledge of medications.

OBJECTIVE

The objective of this study was to explore the feasibility of designing an interactive visualization-based mobile app using an HTA approach through a mobile prototype.

METHODS

Two pharmacists constructed the HTA for the drug risperidone. Later, the specific requirements of the design were translated using infographics. We transferred the wireframes of the prototype into an interactive user interface. Finally, a usability evaluation of the mobile health app was conducted.

RESULTS

A mobile app prototype using HTA and infographics was successfully created. We reiterated the design based on the specific recommendations from the usability evaluations.

CONCLUSIONS

Using HTA methodology, we successfully created a mobile prototype for delivering PPI on the drug risperidone to patients. The hierarchical goals and subgoals were translated into a mobile prototype.
‘As if it was something spoken by a friend’: Digital vote-canvassing networks on Facebook during the 2013 Bangkok Gubernatorial Election Campaign
Authors: Pratheepwatanawong Mukda
Published: August 2019

Vote-canvassers are a central part of Thai elections and this role has been integrated into the digital age. The relationships among the election candidates, vote-canvassers and voters are fundamental in managing the network of communication during election campaigns.  Adapting the idea of the traditional vote-canvassing network for the analysis of electoral politics in the digital arena and using the concept of two-steps flow, this paper explores the way in which Facebook was used to establish and develop ‘digital vote-canvassing networks’ during the 2013 Bangkok gubernatorial election campaign, with the use of multimodal analysis and interviews election candidates and their public relations personnel for data collection. This paper argues that vote-canvassing systems become ‘digital’ when a candidate’s public relations personnel acted as core vote-canvassers to manage and transmit campaign messages on the candidate’s Facebook page on behalf of the candidate, while the candidate’s followers interacted and spread the candidate’s campaign message to their own networks, enabling more SNSs users to be exposed to the campaign content. The mediation of election campaign is no longer only dominated by candidates or political parties, but public relations personnel who demonstrated their value and skills in managing as well as personalising the dissemination and interaction of messages that candidates aimed to communicate to their followers. The development of relationships among people connected to the digital vote-canvassing networks was integrated through the coordination and dissemination of campaign content on Facebook to enhance the electoral ties between candidates and voters. Thus, the spreading of content on Facebook in part mirrors the traditional ‘vote-canvassing system’ in terms of the importance of networks. Both the networks of SNSs and traditional ‘vote-canvassing system’ involve the idea of network expansion, influential communication and development of relationships between people connected on the network. The core idea of digital vote-canvassing networks is to make campaign messages on SNSs reach as many SNS users as possible.
Ospemifene versus local estrogen: adherence and costs in postmenopausal dyspareunia
Authors: Faught Brooke M , Soulban Graziella , Yeaw Jason , Maroun Christiane , Coyle Katharine , Schaffer Samuel , DeKoven Mitch
Published: August 2019

Aim:
Objective was to compare adherence and persistence, as well as direct healthcare costs and utilization, of ospemifene to available local estrogen therapies (LETs).
Patients & methods:
This retrospective database study used integrated medical and pharmacy claims data from the IQVIA Real-World Data Adjudicated Claims – US Database.
Results:
Ospemifene patients had significantly greater adherence and persistence compared with the other nonring LETs. Ospemifene had the lowest mean outpatient costs of any of the LET cohorts, including the estradiol vaginal ring. Total all-cause healthcare costs were also significantly less for ospemifene patients compared with all other LETs.
Validation of the Moral Foundations Questionnaire with three Chinese ethnic groups
Authors: Du Jun
Published: August 2019

Moral foundations theory is claimed to be universally applicable and is classified into 5 foundations of morality: care/harm, fairness/cheating, loyalty/betrayal, respect/subversion, and purity/degradation. This theory has not been tested in the Eastern cultural context. Therefore,
in this study I addressed this lack in the context of China, where there are people of a number of different ethnicities. I adopted the Moral Foundations Questionnaire, which was completed by 761 Chinese of Han, Uygur, and Tibetan ethnicity. The results show that there was no gender difference
in morality foundation scores, but the differences among ethnic groups were significant: Tibetans scored lower than did Han and Uygur in care and fairness, and Uygur scored higher than Han and Tibetans did in loyalty, respect, and purity. The interactions between gender and ethnic group were
significant for care, fairness, and respect. These findings suggest that moral foundations theory is applicable to China, that the Moral Foundations Questionnaire can also be partially applied to Chinese, and that ethnicity is an influential factor when people make moral judgments.
How does intergroup threat affect the shifting function? The moderating role of group identification
Authors: Chen Yujie , Quan Shanshan , Chen Bing , Zhao Yufang
Published: August 2019

In this study we examined whether the shifting function can be modulated by intergroup threat, and if so, how this works. We conducted 2 experiments, using a task-switching paradigm, the results of which provide converging evidence that intergroup threat can impair the shifting function.
Results showed that participants in the threat condition in each study (Study 1 symbolic threat: n = 29; Study 2 realistic threat: n = 29) experienced greater shifting costs than did in the control condition (Study 1: n = 29; Study 2: n = 28). Further, group identification
moderated the depletion effect in the intergroup threat condition, with participants closer (vs. less close) in group identification showing greater switching costs following the intergroup threat intervention. In sum, these results suggest that intergroup threat could deplete switching ability,
and this effect could be influenced by group identification. In future studies researchers should investigate more kinds of intergroup threat than those we used in this study to assess the generalizability of our findings.
Exploring gender stereotypes about interpersonal behavior and personality factors using digital matched-guise techniques
Authors: Dennhag Inga , Steinvall Anders , Hakelind Camilla , Deutschmann Mats
Published: August 2019

We explored gender stereotypes among Swedish university students (N = 101) who were studying a course in psychology, using a matched-guise experimental design. The gender identity of a speaker in a dialogue, manifested by voice, was digitally manipulated to sound male or female.
Responses to the recordings indicated that a speaker with a male voice was rated as significantly less conscientious, agreeable, extraverted, and open to experience than was the same speaker with a female voice. Regarding social behavior, there was a tendency for the speaker with a male voice
to be rated as more hostile than was the same speaker with a female voice. The study findings suggest that stereotype effects, rather than real behavioral differences, may have an impact on perceived gender differences.
Exploring the relationship of green packaging design with consumers' green trust, and green brand attachment
Authors: Yang Yi-Chun , Zhao Xin
Published: August 2019

With growing concern over environmental issues, the effect of green design on consumer behavior is becoming increasingly more important. We established a framework based on extant research and further proposed that there are five dimensions (i.e., environmental protection, safety, packaging
design concept, environmental identification, and convenience) that influence consumers' green trust, in turn, facilitates green brand attachment. In this study we applied structural equation modeling, and data were collected from 286 Taiwanese consumers. The results suggest that green packaging
design is a strong predictor of green trust, which enhances green brand attachment. Moreover, green trust is an effective mediator between green packaging design and green brand attachment. The findings help fill the gap in the literature regarding the relationships among, green packaging
design, green trust, and green brand attachment.
Factors affecting psychological distress among Asian American and non-Hispanic White older adults
Authors: Paek Min-So , Seo Suhyeon , Choi David
Published: August 2019

We examined factors affecting psychological distress in non-Hispanic White (n = 9,170) and Asian American (n = 1,417) older adults, using 2015–2016 California Health Interview Survey data. Multivariate logistic regression analyses revealed that disability, poor/fair
health, and neighborhood environmental factors, such as unsafe neighborhoods and low social cohesion, were significantly associated with psychological distress in both ethnic groups. People aged between 65 and 69 years, women, nonhomeowners, and those living at less than 200% of the federal
poverty level had increased odds of psychological distress among the non-Hispanic Whites. For Asian Americans, physical inactivity was associated with an increased rate of psychological distress. These findings indicate that multiple risk factors increase the probability of psychological distress
in older adults. Further, important similarities and differences exist between older Asian Americans and non-Hispanic Whites, which have implications in screening and development of interventions for these ethnic groups.
Analysis of Animal Accidents along the Road of Padamara-Karangcegak in Geospatial Perspective
Authors: Shalihati Sakinah Fathrunnadi , Sarjanti Esti
Published: August 2019

The occurrence of animal accidents is one of the consequences of physical environmental interaction of animal in terms of their movement from one place to another and non physical environment in the form of transportation usage by human. Accidents happened to animals can affect the structure of the food chain. It would be a matter if it occurred continuously because some species of animals that were important to the ecosystem would not exist anymore. The records of the frequency of animal accident and habitat along Jalan Padamara-Karangcegak by geospatial could be used to analyze the correlation between the dominance of animal species getting the accidents and the potential width of the habitat owned along the road. Qualitative description was used as the method of the research. It was from the primary data analysis of the distribution of accident and secondary data of the land use from Google Earth of  satellite image which was then processed by Geographic Information System. The results obtained during observations from April to July 2016 showed that there was a correlation between the animal habitat and the accidents happened. The animal with a wider habitat dominated the accidents occurred than animals with no extensive habitat.
Local Food Potentials and Agroecology in Yogyakarta Special Province, Indonesia
Authors: Widiyanto Dodi
Published: August 2019

This paper attempts to unveil the hidden potential of the local food through local food mapping, drawing local food potential based on the “triple burden” theory from Professor Moerdijati Gardjito. An index, called “index of food relocalisation” is adopted and then modified into different name called local food index due to data availability, which is expected to provide a geographical location of the local food potential by proposing a research questions: where do the local food potentials distribute in Yogyakarta Special Province, and why the local food potentials located in that particular area(s)? The findings show that Gunungkidul and Kulonprogo are two potential regencies with their local food crops availabilities This finding is accompanied by an explanation from the analysis from the agroecological subzone and spatial income distribution of paddy and second crops, production activities.
Preliminary Assessment of Morphometric and Hydrological Properties of Six Watersheds in the Eastern Part of East Java
Authors: Indarto Indarto , Hidayah Entin
Published: August 2019

A hydrological process on the watersheds is driven by rainfall as the input. Physical properties  also affect the magnitude response of the watershed to produce run-off. This paper presents the identification, assessment and visualisation of morphometric and hydrological properties of the watersheds.  Six watersheds in the eastern part of East Java were used for the analysis.  Physical characteristics obtained by cropping the GIS layer with a watershed. Topographic and morphometric properties of the watersheds derived from the ASTER G-DEM2. Furthermore, hydrological properties are derived statistically by analysing available rainfall and discharge data. Hydrological data (rainfall and discharge) are available from 1996 – 2014.  Finally, simple statistical analysis by plotting obtained values are used to interpret the relation between morphometric and hydrological properties of the watersheds. The results show the quantitative number (unit) to describe the morphometric and hydrological properties of the six watersheds that can be used for watershed classification.
Tourist Attraction Popularity Mapping based on Geotagged Tweets
Authors: Wibowo Totok Wahyu , Bustomi Ahmad Faizan , Sukamdi Anggito Venuary
Published: August 2019

The development of tourist attractions is now highly influenced by social media. The speed at which information can be disseminated via the Internet has become an essential factor in enabling distinct tourist attractions to potentially gain high popularity in a relatively short time. This condition was not as prevalent several years ago when tourism promotion remained limited to a certain kind of media. As a consequence, rapid change in the relative popularity of tourist attractions is inevitable. Against this, knowledge of tourist attraction hotspots is essential in tourism management. This means there is a need to study how to both quickly determine the popularity level of tourist attractions and encompass a relatively large area. This article utilised tweet data from microblogging website Twitter as the basis from which to determine the popularity level of a tourist attraction. Data mining was conducted using Python and the Tweepy module. The tweet data were collected at the end of April and early May 2017, at times when there are several long holiday weekends. A Tweet Proximity Index (TPI) was used to calculate both the density and frequency of tweets based on a defined search radius. A Density Index (DI) was also used as a technique for determining the popularity. The results from both approaches were then compared to a random survey about people’s perceptions of tourist attractions in the study area. The result shows that geotagged tweet data can be used to determine the popularity of a tourist attraction, although it still only achieved a medium level of accuracy. The TPI approach used in this study produced an accuracy of 76.47%, while the DI achieved only 58.82%. This medium accuracy does indicate that the two approaches are not yet strong enough to be used for decision-making but should be more than adequate as an initial description. Further, it is necessary to improve the method of indexing and the exploration of other aspects of Twitter data.
Moniaksiaalisen kuormitushistorian ääriarvopistedatan sykliluokitus Wang-Brown-menetelmän avulla
Authors: Yanchukovich Alexei , Ahola Antti , Björk Timo
Published: August 2019

Artikkelissa esitetään moniaksiaalisen väsyttävän kuormituksen aikahistorian sykliluokitusta Wang–Brown-menettelyllä ja sen soveltamista ääriarvopistesuodatettuun dataan. Perinteisen yksiaksiaalisen kuormitushistorian sykliluokitus aloitetaan datan ääriarvopistesuodattamisesta eli ennen sykliluokitusta datasta poistetaan kaikki muu paitsi ääriarvopisteet. Moniaksiaalisen kuormituksen tapauksessa pelkän ääriarvopistedatan käyttö voi johtaa ongelmatilanteisiin Wang–Brown-sykliluokituksen käytön yhteydessä. Potentiaaliset ongelmatilanteet eivät ole vain teoreettisesti mahdollisia erikoistapauksia, vaan voivat olla esimerkiksi pyörivien koneenosien hyvin tyypillisiä kuormituksia. Työssä on esitetty ääriarvopistedatan Wang–Brown-sykliluokituksen käyttöön liittyvät potentiaaliset ongelmatilanteet sekä mahdolliset keinot niiden välttämiseksi.
Essee teknillisen mekaniikan tutkimuksen eettisistä kysymyksistä ja haasteista
Authors: Frondelius Tero , Mäntylä Antti , Vaara Joona
Published: August 2019

Artikkeli on koostettu kolmesta kurssin 920002J, Tieteellinen tutkimus ja etiikka, kevään 19.03.–10.04.2018 esseestä, jotka käsittelevät tutkimuksen eettisiä kysymyksiä ja haasteita. Teknillisen mekaniikan alalla tieteen etiikasta keskustellaan aivan liian vähän, ja tämän artikkelin tarkoituksena on toimia keskustelun avaajana toivottavasti samalla tuoden myös uusia näkökulmia aiheeseen. Osa näistä eettisistä asioista on Suomessa syntyneelle, eläneelle ja suomalaisen arvomaailman omaavalle henkilölle itsestäänselvyyksiä.
Patentability of mathematical modelling and simulation methods
Authors: Holopainen Sami , Piirilä Olli-Pekka , Salmela Antti
Published: August 2019

"Patentability" refers to conditions laid down by law to what can be patented and what cannot. In this study, changes in the patentability of simulation methods are compared with the rapid development of computational science since 1970s. Although technological progress has caused computational simulation and modelling methods to grow to an everyday tool of technology, these methods have traditionally been excluded from patentability as "non-technical subject matter" or "abstract ideas". We describe the changes in patentability criteria in Europe and in the USA, and illustrate the development of patenting activity in this field during the last decade. Practisers should be aware of these changes, and investigate the possibilities they might offer.
Álgebra e Modelagem Matemática: um panorama das pesquisas brasileiras nos últimos anos
Authors: Cedraz Camilla , Merlini Vera , Santana Eurivalda , Madruga Zulma
Published: August 2019

Nesse artigo, apresenta-se um panorama de estudos que envolvem Modelagem Matemática e Álgebra, voltados para a Educação Básica, com o objetivo de analisar como as pesquisas utilizam a Modelagem Matemática para auxiliar nas aulas de Álgebra. Para isso, foi realizada uma busca de dissertações e teses acerca dos temas citados, no Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), e a partir disso, foi realizado um refinamento e análise das pesquisas encontradas. Observou-se como esses trabalhos abordavam os conteúdos de Álgebra e de que maneira a Modelagem Matemática os auxiliou no processo. Como resultado, pode-se perceber que há pesquisas relacionando Modelagem Matemática com conteúdos de Álgebra, os quais em sua maioria abordam o conteúdo de funções com enfoque no Ensino Médio.
Palavras-chave: Modelagem Matemática. Álgebra. Panorama.
Enhancing internationalisation through inter-institutional collaboration
Authors: Frank Andrea I.
Published: August 2019

Although internationalisation has been identified as a key transformative factor of higher education at the beginning of the 21st century and is firmly embedded in most institutional missions, there is growing concern amongst educators that internationalisation is being devalued and that the progress of its implementation has stalled. One particularly worrying aspect is a rather limited, predominantly instrumental implementation of internationalisation by institutions subsumed by neoliberal ideologies, economics and rankings, which prioritises international student recruitment over enhancing intercultural understanding, curricula and students’ personal development. Responding to calls to re-orient institutional missions, this reflective essay seeks to stimulate a discussion of how aspirations of socially responsible internationalisation (internationalism) and learning for global citizenship may be reclaimed. Drawing on selected cases from the field of spatial planning, the author suggests that interinstitutional collaboration and partnerships could be a valid means to support (explicitly or implicitly) socially responsible internationalisation while also covering institutional performance targets. Cases are interrogated for their rationale (aims, institutional arrangements, focus) to gain an understanding of how they address various aspects of internationalisation and to draw lessons for wider adoption.
Planning the mirage
Authors: Chakravarty Surajit , Qamhaieh Abdellatif
Published: August 2019

Throughout the 1980s planning educators disagreed on the appropriateness of Western planning education for poor countries’ students, and on the question of whether training of students from developing countries should be based on “general principles” or “contextual material specific to poor countries” (Sanyal, 1990, p.8). Today most planning programs in North America (and in the West in general) offer courses in ‘international development’, ‘world cities’, ‘urbanization in the global South’, or closely related topics. However, as ‘the other’ becomes more mainstream in Western planning education, the belief that Western planning education is robust enough to accommodate global differences (the ‘one world’ model of planning education), becomes more entrenched. Further, an unspoken assumption goes unquestioned – that planning curricula, too, just like planning skills, can be transferred internationally. Over the last three decades or so, the advent of the age of interconnected economies and the networked society, has had a profound impact on global trends of development and urbanization. This paper argues that the question of appropriate planning curricula ought to be revisited especially from the perspective of education in developing countries. Scholars educated in the West, who are teaching in developing countries, are in a unique position to assess the utility of bringing Western planning education to less developed parts of the world. This paper is based on the authors’ observations and experiences over seven years, teaching Urban Planning at undergraduate level at a private university in Abu Dhabi. During this period the authors were involved with program design, course design, accreditation and quality assurance, mentorship, along with university service, teaching, and research. The paper evaluates the practices and circumstances of urban planning in UAE and the implications for planning education. It is argued that there is a fundamental disconnect between the profession’s ethics, and the reality of planning practice in the region. This gap has not been considered in depth in either program design or in accreditation standards. The paper concludes with recommendations for planning education in the Gulf region.
Practical plans
Authors: Cremaschi Marco
Published: August 2019

Migration generates both challenges and opportunities. The magnitude of flows and effects on local resources are rarely equally distributed, indeed, the demographic size and economic strength of arrival cities or regions consistently affect outcomes. The nature of these challenges and opportunities is, therefore, extremely varied. These elements have already structured a network of places, refugee-cities, integration hubs, and transit points that play different roles in the increasing process of human mobility. The paper discusses the role of planners in dealing with refugee crises starting from the experience of a university workshop. This allows for a plea in favour of a different approach to planning, one that insists on practice, spatial strategies, and implementation. The paper also illustrates a different teaching approach that takes into account the need to integrate different forms of knowledge and disciplinary perspectives.
Modern interregional migration: evidence from Japan and Poland
Authors: Dzienis Anna Maria
Published: August 2019

This paper provides data-based analyses of recent interregional migration considering the examples of Japan and Poland. The analyses are conducted against the background of the general demographic and economic situations of both countries, in particular, regional disparities and economic growth. They aim at describing migrants’ behavior in Japan and Poland through a model consistent with the New Economic Geography (NEG) theory. Inspired by the model originally proposed by, the study constructs a migration model coherent with the NEG framework and tests the behavioral hypothesis. Interestingly, in both Japan and Poland, migrant behavior is responsive to stimuli stemming from the two following mechanisms: the relationship between the level of income inequalities and net migration toward capital regions; and similarly, the relationship between income inequalities movement and gross domestic product growth rate.
Biological Markers – Predictors of No-Reflow Phenomenon After Primary PCI in Patients with ST-Segment Elevation Myocardial Infarction
Authors: Pantea-Roșan Larisa Renata , Moisi Mădălina Ioana , Pantea Vlad Alin , Ţica Otilia , Ţica Ovidiu , Babeș Katalin , Polojintef-Corbu Dorina , Popescu Mircea Ioachim
Published: August 2019

Lipid parameters along with the biological markers of myocardial necrosis play an essential role in highlighting the patient at an increased risk of developing the no-reflow phenomenon from an STEMI. This phenomenon is due to primary PCI failure of blood flow in the coronary microcirculation, although the artery involved in the infarction is disintegrated.
Comprehensive Lifestyle Interventions in Obstructive Sleep Apneea
Authors: Hâncu Anca Mihaela , Mihălţan Florin Dumitru
Published: August 2019

There is a complex link between obesity and obstructive sleep apneea (OSA), and there are new guidelines for comprehensive lifestyle interventions (CLI) for weight loss, with beneficial results on obese patients with OSA. A structured algorithm is proposed, step by step, according to BMI. All these recommendations are evidence based, a large meta-analysis is further discussed as an evidence base.

Implications in clinical practice outline: the effectiveness of lifestyle changes in reducing OSA outcomes, higher efficiency for complex interventions on male patients with severe OSA, duration of the intervention and combination with CPAP usage are not statistically correlated with lifestyle interventions effects on OSA. Different types of food affect sleep quality, high fat diets and processed meat are correlated with OSA. Higher adherence to Mediterranean Diets, that is very common used in CLI is a predictor for OSA outcomes improvement. Metabolic bariatric surgery MBS, indicated for a specific group of patients will ameliorate OSA. Building a long term partnership with the patients with OSA and obesity will ensure adherence to therapeutically measures and finally good results in improving quality of life.
Between the denial of realities and pragmatism: migration-led regeneration in Genova and Manchester
Authors: Hillmann Felicitas
Published: August 2019

Starting from the assumption that urban politics are a fundamental part of an evolving local governance of migration, this article investigates the overlappings between migration-related policies and migrant agency on one hand and urban regeneration policies on the other hand. As European cities are embedded in (supra-)national migration regimes, the institutional responses on migration vary accordingly. The here presented comparison between two cities in two migration regimes allows for an understanding of common traits and differences of the urban governance of migration across the different migration regimes. For this purpose the situation in Genova (Italy) and Manchester (UK) is in the focus of the analysis. The comparison reveals that as well cities with long-established migration policies as those with a poorly developed institutional setting strongly rely on the agency of the civil society. Migration-led regeneration takes place, but is not framed explicitly within the urban policies and strategies of regeneration.
Change of the rural area in the knowledge society
Authors: Kujath Hans Joachim , Dehne Peter , Stein Axel
Published: August 2019

In the knowledge society, spatial structure is differentiated, and as a result of this process the rural area no longer appears as a homogenous entity. The “reflexive modernity” of the knowledge society does not seem to know any determinism concerning spatial development-differences, but rather provides new scope to people for acquiring and valorizing different areas. New development impulses could be triggered in the so far peripherally assessed rural area through those extended options. In order to review these assumptions, this paper asks from a theoretical perspective how the cultural, social, economic and technical dimensions of the knowledge society interact with space, and what challenges and strategies may arise for rural areas. The empirical verification is based on results of a working group of the Academy of Spatial Research and Planning (ARL) about the knowledge society in rural-peripheral regions and more qualitative and quantitative studies about the topic. Analysis shows that in many, but not in all regions new knowledge society shaped life cultures evolved differentiating from urban social models. They prove a new attractiveness of the rural area, which are also expressed in knowledge-based projects of culture, education, public services and entrepreneurial commitment. There are a lot of examples especially in economic competitive regions but also in peripheral regions suffering population loss. It needs more studies to determine how the approaches can be used by public and private players to promote the knowledge-society based change. They could help using the gained experience in successful regions for political and planning support in peripheral rural towns and regions.
The RESPONSE OF SUGARCANE GENOTYPES SUBJECTED TO SALINITY STRESS AT DIFFERENT GROWTH PHASES
Authors: R. Arunkumar C. Brindha, S. Vasantha,
Published: August 2019

A few commercial sugarcane genotypes were subjected to salinity stress at various growth phases of sugarcane to ascertain the critical growth stage for salinity stress and to assess the response of the genotypes. All the data were recorded and analysed during maturity phase. The salt treatments drastically reduced SPAD chlorophyll, chlorophyll fluorescence, RWC, stalk height, weight and other yield parameters in a few genotypes during T2 (salt treatment given during formative phase) & T5 (salt treatment given throughout crop cycle) but a few genotypes which are tolerant towards salt stress gave better results comparing other genotypes. The ions like sodium, potassium and chloride were analysed in the juice which showed higher elevation in the genotype Co 97010. Among the genotypes, Co 85019 and Co 99004 recorded significantly prime compared to rest of the genotypes. Treatment throughout the growth phases (T5) followed by stress at formative phase (T2) were found to be critical for growth, physiological and yield responses in all the genotypes.