bluuebunny/crossref_metadata_2025 huggingface dataset:
Lateral Flow Immunoassay As Novel Screening Tool For Potential Cross-Reacting Protein In Crude Plant Latex As Tested For Plasmodium, Dengue, HBV, HCV, HIV
Authors: - Sriram Kannan , - Deblina Mitra , - Sreevani Kannan , - Anierudhe Venkatavaradhan
Published: July 2023

In vitro diagnostic kits use immune chromatographic assay with gold nanoparticle conjugated antigen / antibody coated in the kit that specifically detects the antigen of the pathogen or antibody to a pathogen in the blood or serum tested. Such kits are available for wide variety of diseases and different kits could use different antigens targeted. In this research article I present the novel finding that when the latex of Calotropis gigantea or Thevetia peruviana is used as the sample in a kit targeting the Histidine rich protein of Plasmodium falciparum, the kit displayed positive reaction which indicates homologous protein exists in the latex of these two plants to that of the Histidine rich protein of Plasmodium falciparum. Similarly, it was noticed for the LDH protein of P. vivax and Calotropis gigantea. Further it was noticed that the latex of Calotropis gigantea, Tabernaemontana divaricate had activity against HCV, Dengue, HIV. The latex of Carica Papaya had activity against HCV. Hence this article brings out the novel concept of use of human pathogen specific lateral flow kits for screening of plant latex and sap to identify potential cross-reacting proteins that even a layman can screen and doesn’t require expertise like docking studies. Further this could pave way for layman to use these LFA for screening of plant proteins of medicinal interest or to use of these plant extracts for detecting antigens, antibodies in human sera of a particular pathogen that can cross react with plant latex and produce agglutination.
Additional Effects of Medial Wedge Insole Coupled with Conventional Therapy in Patients with Bilateral Lateral Compartmental Knee Osteoarthritis: A Clinical Trial Study
Authors: Fatema Campwala  , Vinit Mody
Published: July 2023

Background: Osteoarthritis (OA) is the most prevalent disorder of the locomotor system, and involves the largeweight bearing joints of the lower limb such as knee joint. The progression of OA knee is typically affected bymechanical stress created by varus and valgus malalignment, which in turn overloads the medial and lateralcompartments, respectively. The rationale of wedged insoles is to transfer the load from the affected kneecompartment to the joint contralateral compartment. So, the aim of the study was to compare the effectiveness ofconventional therapy plus medial wedge insole in the footwear and conventional therapy alone on pain, physicalfunction and alignment in lateral compartmental knee osteoarthritic patients.Method: Study included 30 patients with bilateral lateral compartmental knee OA, aged 40-60 years anddivided into 2 groups: Group A received conventional therapy plus medial wedge insole and Group B receivedconventional therapy alone for 6 weeks (3 sets of 10 repetitions daily). Inter-group analysis by unpaired t-testshowed statistically significant improvement in Lequesne index score and tibiofemoral angle (P value ≤ 0.05).Conclusion: In patients with lateral compartmental knee OA, conventional therapy plus medial wedge insole weremore effective than conventional therapy alone in reducing pain, improving functional disability and tibiofemoralangle.
Rashid Rida: A “Passage to India”... and Kuwait
Authors: Ezzahoui Ikrame
Published: July 2023

In May 1912, under the combined influence of the reformist currents of Egypt and the Indian Ocean, the first school described as “modern” in the country, was created in Kuwait. At the same time, the tenth congress of the Association of Indian Ulemas was held in Lucknow, bringing together reformist intellectuals influenced by the legacy of the famous Sayyid Ahmad Khan who died in 1898. The presence of the Syrian thinker Rashid Rida at these two events is a little-known historical fact, despite its importance, right when the ideas of reformism were experiencing an unprecedented increase in circulation in the major port cities of the Persian Gulf. Rida's account of the trip shows how the theme of education was given an unprecedented political and internationalist meaning by the Muslim elites of the Indian Ocean ; a region strongly connected by its port synapses where both mercantile and intellectual networks wove and intertwined together.
Burying Mohamed Ali Jauhar: The Life and Death of the Meccan Republic
Authors: Willis John M.
Published: July 2023

This article looks at the hitherto ignored project by the Indian Khilafat Movement to establish a republican government in the city of Mecca after the collapse of the Ottoman Empire. It argues that while activists of the Khilafat Movement were able to articulate an ethical vision of a transnational state rooted in the Islamic concept of fraternity (ikhvat), they were unable to effectively bring this vision to bear on the domain of the political, especially in the confrontation with the emerging power of the Saudi state and its intellectual allies.
Le Pakistan, l’Inde et les pays du Conseil de Coopération du Golfe : idéologies, géopolitique et realpolitik
Authors: Racine Jean-Luc
Published: July 2023

Alors que l’hégémonie politique du nationalisme hindou marginalise des musulmans indiens, la politique étrangère de Narendra Modi ne souffre guère de son image dans les États du Golfe, Arabie saoudite et Émirats arabes unis au premier chef, les principaux partenaires de l’Inde dans la région. Les tentatives du Pakistan de faire condamner la politique indienne, au Cachemire en particulier, ne rencontrent qu’un écho mesuré, plutôt au sein de l’Organisation de la Coopération islamique que dans les relations bilatérales. La coopération militaire entre Riyad et Islamabad n’a pas été jusqu’à envoyer des forces pakistanaises au Yémen, et la crise économique qui frappe le Pakistan l’a rendu dépendant des soutiens financiers venus du Golfe. Par contraste, l’Inde n’est plus seulement un pays à forte diaspora dans le Golfe, et un client important pour le pétrole : elle est aussi une terre d’investissements, et entretient un dialogue de coopération stratégique avec le Conseil de Coopération du Golfe. Bref, la realpolitik l’emporte.
Controlled Synthesis and Electrical Properties Study of GeAs2Te4 Single Crystals
Authors: Yu Meng Xi , Chen Jia Wang , Du Yu Chen , Han Wang Zi , Mei Ming , Zhu Xiang De , Li Liang
Published: July 2023

Exploration of the optoelectronic memristor is required to investigate the photoelectric properties of materials. The traditional memristor material GeAs2Te4 is hopeful to be developed into a new type of optoelectronic memristor. However, acquiring high-quality single crystals remains challenging, and the electrical properties of single crystals of GeAs2Te4 need to be explored. Herein, a controlled method is introduced to grow reliable quality GeAs2Te4 single crystals, and the electrical and optoelectronic properties are studied. The photodetector based on GeAs2Te4 exhibits acceptable optoelectronic performance at designed low temperatures. The responsivity and detectivity of the GeAs2Te4-based photodetector reached the value of about 0.137 A W-1 and 6.9×107 Jones, respectively. It is promising to introduce this family of materials into the field of photodetector and also maybe further in the area of optoelectronic memristors.
Evaluation of Chitosan and Potato Starch as Stabilizers to Improve the Mechanical and Water Durability Properties of Printable Earth-Based Matrices Reinforced with Sisal Fibers
Authors: Zavaleta Diana , Ñañez Robert , Silva Guido , Kim Suyeon , Ruiz Gaby , Pando Miguel A. , Nakamatsu Javier , Aguilar Rafael
Published: July 2023

Due to economic, sustainable, and aesthetic benefits, academia and the construction industry are exploring the use of earth in modern construction is being widely studied. Unfortunately, earth as a construction material has low mechanical, poor water durability resistance, and the potential to swell and crack. Therefore, this paper evaluates chitosan and potato starch, natural biodegradable polymers, as stabilizers to improve mechanical strength and water durability resistance of printable earth-based matrix reinforced with sisal fibers. Although the test results indicated that the chitosan had a better performance as an earth stabilizer than potato starch, adding both stabilizers resulted in earthen composites with higher compressive strength and lower water permeability. These results demonstrate the feasibility of using natural stabilizers to improve the performance of earth-based materials for 3D printing without affecting their printability capacities.
Auralization of Unsteady Rotor Noise using a Solution to the Ffowcs Williams-Hawkings Equation
Authors:   NASA, Krishnamurthy Siddhartha ,   Analytical Mechanics Associate, Tuttle Brian , Rizzi Stephen
Published: July 2023

Auralization of unsteady helicopter flight operations is needed to better understand the impact of maneuvers on community noise. Previous source sound synthesis methods were based on interpolated data, which may lead to artifacts in generating sound for helicopter maneuvers where sound pressure directivity may change rapidly. In this paper, the source sound is synthesized at every time sample using a solution to the Ffowcs Williams-Hawkings Equation along the path of the emission angle between the source and a ground observer. The synthesized sound is then propagated to the ground observer for auralization. Since no interpolation is performed, maneuvers with rapidly changing sound pressure directivities may be more accurately synthesized and auralized. The framework for accomplishing this synthesis and auralization is described, which couples the Fundamental Rotorcraft Acoustic Modeling from Experiments, the second-generation Aircraft NOise Prediction Program, and the NASA Auralization Framework. Synthesis of a hovering rotor is presented to compare with previous synthesis methods. Two examples with aperiodic signals are then presented to demonstrate synthesis and auralization of unsteady rotor noise.
Identification and Prediction of Broadband Noise for a Small Quadcopter
Authors:   NASA Langley Research Center, Pettingill Nicole , Zawodny Nikolas
Published: July 2023

The growing interest in the noise of small unmanned aircraft systems (sUAS) in operation has motivated this study to characterize and predict broadband rotor noise sources. This paper analyzes the performance and acoustic data collected from two sets of wind tunnel experiments for hover and forward flight operating conditions. The first set of data is a result of testing a representative vehicle configuration of the Straight Up Imaging (SUI) Endurance quadcopter, while the second set of data represents an isolated rotor from the same vehicle. Following the analysis of the empirical data, a broadband noise prediction methodology is employed to compare with the experiments. This methodology uses NASA's ROTONET and BARC tools to predict blade loading and self-noise at conditions matching the wind tunnel experiments. This methodology is effective at predicting the broadband noise at certain conditions. Furthermore, some predictions are repeated with the inflow conditions calculated by the rotorcraft analysis tool CAMRAD II, which shows improved prediction results for cases with non-uniform inflow. This work confirms some of the unique challenges associated with testing small rotor configurations, explores the limitations of this prediction methodology, and suggests improvements that can be made for future studies.
Aeroacoustic Analysis of UAV-Scale Cycloidal Rotor: An Experimental and Computational Approach
Authors:   Texas A&M University, Halder Atanu , Kellen Adam , Benedict Moble
Published: July 2023

The cycloidal rotor is a novel configuration which has shown significant aerodynamic performance benefits when compared to a conventional rotor at MAV (Micro Air Vehicle) scale. The objective of the present study is to investigate the aeroacoustics of larger size UAV (Unmanned Aerial Vehicle) scale cycloidal rotors through a well-balanced experimental and computational approach. To predict the noise of the cycloidal rotor, an aeroacoustic framework is developed which consists of an aeroelastic model of the cycloidal rotor coupled to an acoustic solver. The aeroelastic framework of cycloidal rotor is developed by coupling a high fidelity unsteady aerodynamic model with a fully nonlinear geometrically exact beam model. The aerodynamic loads predicted by the aeroelastic model of cycloidal rotor are utilized by the acoustic solver to generate loading noise. The harmonic noise is predicted using Ffowcs Williams - Hawkings solver tailored to the kinematics of the cycloidal rotor. The aerodynamic and acoustic performance of cycloidal rotor predicted by the developed model is validated with results obtained from in-house experiments. For this purpose, systematic experiments were conducted to measure thrust, power and sound pressure level of a UAV scale cycloidal rotor while varying different rotor design parameters. The aeroacoustic framework is then utilized to understand the acoustic benefits of the cycloidal rotor. The aerodynamically generated noise of the cycloidal rotor is concentrated in the blade passing frequency, with little noise generated at higher harmonics. Due to the low operating rpm of the cycloidal rotor, this will lead to considerable decrease in A-weighted noise levels. The model developed in this paper can be utilized for design and optimization of quiet and efficient next generation cycloidal rotors.
Aeroacoustic Modeling of an eVTOL Slowed Rotor Winged Compound Aircraft
Authors:   Continuum Dynamics Inc., Quackenbush Todd ,   Piasecki Aircraft, Ricci-Moretti Luigi ,   Pennsylvania State University, Brentner Kenneth , Wachspress Daniel , Barwey Dinesh , Lewis Robert
Published: July 2023

Piasecki Aircraft Corporation (PiAC) and Continuum Dynamics, Inc. (CDI) are investigating noise levels of the PA890,an emergent eVTOL slowed rotor winged compound (SRWC) configuration using the CHARM/PSU-WOPWOP aeroacoustic analysis. While the adoption of electric drive eliminates engine noise, this design allows several operational degrees of freedom that permit it to further mitigate noise mechanisms associated with conventional single rotor helicopters, including: lift compounding to offload the main rotor; reduction of main rotor RPM in cruise; and a dual mode (antitorque/pusher) tail rotor that allows alternate modes of operation for targeted forward flight conditions, with significant potential for noise reduction. This paper provides an overview of an acoustics analysis of the PA890 eVTOL SRWC configuration, including a comparison to an existing single rotor civil helicopter; and the principal noise mechanisms affecting each type of aircraft and the opportunities offered by the SRWC configuration to mitigate them. Ongoing work to further clarify important noise mechanisms is also outlined.
Tonal Noise Control using Rotor Phase Synchronization
Authors:   NASA Langley Research Center, Schiller Noah , Pascioni Kyle , Zawodny Nikolas
Published: July 2023

The purpose of this study is to determine if phase synchronization can be used to reduce the net radiated sound power from two rotors. Phase synchronization implies that the rotors have the same rotational speed with a fixed relative azimuthal blade position, or phase. The concept is evaluated both experimentally and numerically. Measurements of source directivity and thrust are initially compared with predictions to confirm that the model accurately captures the relevant trends. The model is then used to explore the design space and identify relevant parameters. Both experimental and numerical results show that the radiated sound power at the blade passage frequency can be reduced by appropriately controlling the relative azimuthal phase of the rotors. Vehicle level predictions are also provided for a notional octocopter, comparing two different modes of operation. Predictions show that phase synchronization can be used to achieve a 4-5 dB reduction of the sound pressure level at the blade passage frequency nearly everywhere on the ground plane beneath the vehicle.
Rotor/Airframe Aeroacoustic Prediction for eVTOL UAM Aircraft
Authors:   Continuum Dynamics Inc., Wachspress Daniel ,   Pennsylvania State University, Brentner Kenneth , Yu Michael
Published: July 2023

A major innovative thrust in urban air mobility (UAM) is underway that will potentially transform how we travel by providing on-demand, affordable, quiet, and fast passenger-carrying operations in metropolitan areas using electric-powered vertical take-off and landing (eVTOL) aircraft. To support this, it is propitious to enhance existing VTOL aircraft analysis and design tools as necessary and provide these enhanced tools to entrepreneurs attempting to design this new breed of aircraft. In this regard, work was performed to enhance an existing VTOL aircraft aeroacoustics analysis with additional modeling capabilities useful for comprehensive acoustic prediction of Distributed Electric Propulsion (DEP) aircraft noise. The goal is to develop software that will provide fast, accurate prediction of acoustic characteristics associated with DEP aircraft, including (1) noise generated by the simultaneous operation of multiple, variable RPM lifting and propelling rotors and props, (2) interacting rotor/prop/duct/airframe noise, including strut noise and prop/wing interaction noise, (3) broadband noise characteristic of eVTOL configurations, and (4) electric motor noise. This paper describes initial work toward these goals that was performed to enhance and validate a fast method for predicting rotor/airframe noise for combinations of rotor, props, struts, ducts and wings.
Aeroacoustic Study of Coaxial Rotor under Varying Trim Conditions and Rotor Orientations using Free Wake Analysis
Authors:   Pennsylvania State University, Sharma Kalki ,   University of California Davis, Jia Zhongqi , Brentner Kenneth , Lee Seongkyu
Published: July 2023

This paper performs aerodynamic and acoustic analysis on a coaxial rotor system based on the XH-59A coaxial helicopter. The aerodynamic analysis is performed in RCAS using free wake modeling, and the acoustic prediction is performed with PSU-WOPWOP, which utilizes Farassat's Formulation 1A of the Ffowcs Williams-Hawkings equation. The coaxial rotor system is analyzed for forward flight speeds of 100 knots and 150 knots. For each case the rotor shaft angle and the distribution of loading is varied to understand the impact on the rotor noise and the aerodynamic environment of the rotor system. The aerodynamic environment is analyzed by wake and blade load visualization, and the noise is computed on a hemi-spherical grid 10 rotor radii from the coaxial rotor system.
Fundamental Investigation of Proprotor and Wing Interactions in Tiltrotor AIrcraft
Authors:   US Army ADD, Lim Joon
Published: July 2023

Rotor/wing interactions in tiltrotor aircraft are complex in nature. Using an XV-15 rotor on a full-span wing with a symmetric NACA 0023 airfoil section, the mechanisms of rotor/wing interactions are investigated for a tiltrotor aircraft cruising at 220 knots. Numerical computations are performed using HPCMP CREATE™-AV Helios code. Due to the rotor/wing interference, rotor and wing loadings display a 3-per-rev harmonic response. The mean rotor thrust and power are influenced by the interference. Due to the interference, the rotor thrust increases 12.7% and the rotor power increases 8.1%, most of which is due to wing thickness interference. The mean wing lift and drag are also influenced by the interference. Due to the interference, the wing lift increases 0.7% and the wing drag reduces 21.9%. These interference effects are confined to the high speed tiltrotor airplane mode.
Prediction of Rotor Hub Flow Using Mercury Framework
Authors:   University of Maryland, Lee Bumseok , Jung Yong , Jude Dylan , Baeder James
Published: July 2023

In this paper, interactional aerodynamics between rotor hubs and a horizontal stabilizer are predicted using a multimesh paradigm, heterogeneous CPU-GPU framework, Mercury. Mercury framework incorporates three flow solvers at the University of Maryland, 1) OverTURNS, a structured solver on CPUs, 2) HAMSTR, a line based unstructured solver on CPUs, and 3) GARFIELD, a structured solver on GPUs, through an overset grid assembler, TIOGA. Simulations are performed for Penn State University Phase III and low-drag hubs with a far-wake stabilizer, and results are compared against the water tunnel test data including drag coefficient of the hubs, lift coefficient of the stabilizer, and time-averaged velocity wake profiles.
RACER Aero-acoustic Propeller Analysis and Design
Authors:   ONERA, Decours Julien ,   Airbus Helicopters, Fukari Raphaël , Ortun Biel , Bailly Joëlle , Canard-Caruana Sylvette , Delrieux Yves , Guntzer Frédéric
Published: July 2023

This work investigates the lateral rotors of the RACER, Airbus Helicopters high-speed demonstrator. These lateral rotors also defined as propellers, provide anti-torque in hover and thrust in cruise flight. The first action was to better understand the complex aerodynamic interactions that the propellers undergo in hover and cruise flight. Then, in view of optimizing the aerodynamic and particularly the acoustic performance of the propellers, their design was adapted to exploit synergistically the installation effects. Optimization included airfoil optimization and blade design, taking into account structural and manufacturing constraints. By using a smart choice of multi-fidelity simulations, ONERA improved drastically the aerodynamic and acoustic performance of the RACER.
Design Optimization of a Hybrid Spur Gear
Authors:   Pennsylvania State University, Gauntt Sean , Campbell Robert , McIntyre Sean
Published: July 2023

This study develops an optimization technique for a sinusoidal interlock design of a hybrid spur gear consisting of a metallic outer ring to support high contact stress bonded to a composite inner web for weight reduction. Two objectives (mass and shear traction on the metal-composite interface under static loading conditions) were minimized for four design variables subject to two constraints. Borg MOEA, a multi-objective evolutionary algorithm developed at The Pennsylvania State University, and an in-house finite element solver were used to generate Pareto-optimal solutions to this design problem. Two of the designs were then analyzed in greater detail to determine stress distributions throughout the gear. In the future, this technique will be refined and applied to optimization of more representative rotorcraft gears, with the aim of reducing drive train weight and meeting performance requirements.
Fundamental Studies of Lithium Sulfur Batteries for Electric Aviation
Authors:   University of Maryland, Fisler Emily , Datta Anubhav
Published: July 2023

Lithium sulfur (LiS) batteries have the potential to outperform lithium ion batteries and secure a space for both civilian and military electric vertical takeoff and landing (eVTOL) aircraft. The high theoretical capacity of sulfur promises high specific energy LiS batteries that would enable practical eVTOL aircraft. The drawbacks are low cycle count and uncertain behavior at high power. First, results from a conceptual eVTOL sizing code is used to demonstrate the benefits of advanced battery technology with increased specific energy for an intracity air taxi mission with an electric quadcopter. Next, small-scale LiS cells are fabricated with a polyacrylonitrile-sulfur cathode, lithium anode, and various liquid electrolytes. Electrochemical cycling data is analyzed, including tests at high C-Rates. The CRate test showed the ability of the LiS cell to recover initial capacity after experiencing high C-Rates of up to 6C. Microscopy analysis was performed on a cycled LiS cell to observe the cell mechanisms and cause of cell degradation. In conclusion, the advanced specific energy of LiS allows for a more effective quadcopter, with a weight, size, and payload suited for intracity travel. Additionally, characterization of small-scale LiS cells shows high specific capacity and good cycle life of over 600 cycles. Finally, understanding the behavior of larger, scaled up LiS batteries is crucial for eVTOL, and is part of future work.
Routine inflammatory markers are elevated in myelodysplastic syndromes at presentation
Authors: Oster Howard , Sklyar Ekaterina , Golsdshmidt Noa , Mittelman Moshe
Published: July 2023

Background: Immune and inflammatory processes have known contributions to the pathogenesis of myelodysplastic syndromes (MDS). The use of inflammatory markers, minimally used in current practice, is examined.
BARING THE ESSENCE IN DELILLO’S „THE BODY ARTIST“: REACHING THE TRUTH THROUGH FACING DEATH
Authors:   University of Priština temporarily settled in Kosovska Mitrovica Faculty of Philosophy, Ninčetović Nataša V.
Published: July 2023

The Body Artist (2001) is arguably DeLillo’s most unusual novel. The starting point of this research is that this novel deals with the concepts which shape the life of contem- porary man: time, death, and identity. Faced with a severe trauma caused by the death of her husband, the protagonist Lauren Hartke rejects the conventional way of mourning. She responds to the great tragedy that occurred to her with self-isolation and silence. In a secluded house Lauren attempts to stop time and reconsiders her beliefs and assumptions. Testing basic attitudes is enabled by an extraordinary character, Mr. Tuttle. He inspires Lauren to view time, identity, body, and language in a completely new light, which leads her to spiritual transcendence. Truth and spiritual transcendence are possible in DeLillo’s oeuvre and they are usually linked to art and moments of connectedness.
A Cross-Case Analysis Study on Scrum Culture Adoption in Three Digital Startups
Authors:   School of Business and Management, Bandung Institute of Technology., Furoidah Ayu
Published: July 2023

Indonesian startups actively embrace Agile development, but implementation can be difficult due to complexity, rapid change, and ambiguity. Scrum, the most popular Agile methodology, assists organizations in dealing with issues that arise during product development. Cultivating a Scrum culture can also take time, but truly implementing it can increase productivity, product quality, and customer satisfaction. Many businesses embrace Agile without first assessing their values and principles, resulting in poor performance. This study investigates how the value of Scrum is quantified and applied to digital startups, with the goal of understanding metric results for evaluation and recommending a better implementation of Scrum culture. A cross-case analysis study was conducted on three digital startups in Indonesia, with data collected through interviews. To evaluate and enhance Scrum implementation, a Values, Goals, Questions, and Metrics (VGQM) model developed from Scrum values was presented. Businesses demonstrated the same strengths in commitment and focus for Scrum values but needed continuous improvement in different values of respect, openness, and courage for better prioritizing requests and delivering feedback. Based on the findings, recommendations were made, including extensive training, cross-functional collaboration, assessing tools and processes, and establishing clear boundaries for customer satisfaction and productive work. Improving product backlog management and employing effective Scrum tools were also mentioned. There are no metrics used by the companies in order to evaluate scrum culture implementation in their organizations. The study suggests constantly retaining those values, while continuously improving the values of openness and courage.
Can Profitability Intervene in the Effects of Liquidity, Activity, and Leverage on Company Value?
Authors:   Universitas 17 Agustus 1945 Surabaya – Indonesia, Dyah Astawinetu Erwin , Istiono Istiono ,   Universitas 17 Agustus 1945 Surabaya – Indonesia, Rachmawati Titiek ,   Universitas 17 Agustus 1945 Surabaya – Indonesia, Penangsang Parikesit ,   Universitas 17 Agustus 1945 Surabaya – Indonesia
Published: July 2023

This study was conducted to examine the effect of liquidity, leverage, and activity on company value using profitability as an intervening variable. The companies used as research objects are various manufacturing companies in IDX30 listed on the Indonesia Stock Exchange with an observation period of 2016-2021. All collected data was analysed with Smart PLS software. The results of the analysis show that, directly, leverage and activity affect profitability, and profitability affect company value. Meanwhile, liquidity has no effect on profitability. In addition, liquidity, leverage, and activity have no effect on company value. When profitability becomes an intervening variable, profitability amplifies the effect of leverage and activity on company value. However, profitability is not able to strengthen the effect of liquidity on company value.
The Effect of Liquidity, Asset Structure, Capital Structure on Firm Value with Profitability and GCG as Intervening Variables on Non-Cyclical Consumer Listed on the Indonesia Stock Exchange
Authors:   Universitas 17 Agustus 1945 Surabaya, Indonesia, Latipah Nur Siti , Hwihanus Hwihanus ,   Universitas 17 Agustus 1945 Surabaya, Indonesia, Rahmiyati Nekky ,   Universitas 17 Agustus 1945 Surabaya, Indonesia
Published: July 2023

This study aims to determine the effect of liquidity, asset structure, and capital structure on firm value with profitability and good corporate governance (GCG) as intervening variables in non-cyclical consumer companies listed on the Indonesia Stock Exchange (IDX). The data collection technique used in this study is annual report documentation for 6 years starting from 2015- 2021 from Personal Care Product companies listed on the IDX, with a total sample of 5 companies selected through purposive sampling. The collected data were analyzed using Partial Least Squares (PLS) analysis, and the findings were interpreted using a path analysis approach. In conclusion, liquidity and asset structure have a negative relationship with profitability and firm value but have a positive relationship with GCG. On the other hand, capital structure has a negative relationship with profitability and GCG but has a positive relationship with firm value. Profitability has a positive relationship with firm value, while GCG has a negative relationship. Profitability and GCG have a negative relationship as intervening variables in the effect of liquidity and asset structure on firm value but have a positive relationship as intervening variables in the effect of capital structure on firm value.
A Rare Presentation of AKI Due to Retroperitoneal Fibross as A Result of Gastric Linitis Plastica: A Case-Based Review
Authors:   Department of Nephrology at Hospital Center Cannes, France, Marie Habib Anne
Published: July 2023

Short bowel syndrome (SBS) refers to a condition resulting from loss of bowel or loss of small bowel absorptive surface area due to surgical resection or bypass leading to maldigestion, malabsorption and malnutrition.
Uncommon Medical Diagnostic Profiles in Psychiatric Settings Across South-South Nigeria
Authors:   Federal Medical Center, Yenagoa, Bayelsa State, Nigeria, Uche Nwaopara
Published: July 2023

Background: Some medical disorders occurring in psychiatric settings cause diagnostic delays and missed diagnoses which may lead to poor prognosis and outcomes.
Metaverse: Telepresence in 3D Virtual Digital Worlds through the use of Avatars
Authors:   Specialist, Santa Ursula University in Rio de Janeiro-RJ, Brazil, Bogossian Tricia
Published: July 2023

This article addresses telepresence through avatars in virtual environments such as Metaverso. Important concepts such as Metaverse and 3D Virtual Digital Worlds, avatars, presence and telepresence were discussed. The applications of avatar telepresence in a variety of areas, including education, healthcare, entertainment, professional training, and customer service, as well as privacy and security concerns associated with this technology, were also explored.
DESENVOLVIMENTO REGIONAL ATRAVÉS DAS REDES TURÍSTICAS: REGIÃO FRONTEIRA NOROESTE / REGIONAL DEVELOPMENT THROUGH TOURIST NETWORKS: NORTHWEST FRONTIER REGION
Authors: Laurer Sendi , Dalcin Dionéia , Anes Carlos Eduardo Ruschel , Lima Antonio Lucas de Oliveira
Published: July 2023

Os estudos sobre desenvolvimento regional endógeno e associação às redes turísticas prezam pela cooperação e crescimento das entidades e atores sociais que integram determinada localidade. Desta forma, realizou-se uma contextualização acerca dos temas, a fim de compreender o desenvolvimento regional através das redes turísticas. Este estudo pode ser compreendido como um ensaio teórico, tendo como método de pesquisa o levantamento bibliográfico. Entre os principais resultados, verificou-se que para haver um desenvolvimento regional endógeno por meio de uma rede turística, é primordial que o esforço coletivo se sobressaia ao particular, com relações sociais eficientes, empoderamento dos atores sociais, presença de um sistema de turismo que preze pelos interesses coletivos e, principalmente, a importância da participação e do fomento tripartite formado pelo Estado, comunidade civil e pelas empresas privadas.
Abstract: Studies on endogenous regional development and association with tourist networks value cooperation and growth of entities and social actors that make up a given location. In this way, a contextualization about the themes was carried out, in order to understand regional development through tourist networks. This study can be understood as a theoretical essay, having the bibliographic survey as a research method. Among the main results, it was found that for there to be an endogenous regional development through a tourist network, it is essential that the collective effort stands out from the particular, with efficient social relations, empowerment of social actors, presence of a tourism system that cherish collective interests and, above all, the importance of participation and tripartite promotion formed by the State, civil community and private companies.
Sinergia entre ácido hialurónico y luz infrarroja. Estudio preliminar
Authors: Soriano Pascual Noemí
Published: July 2023

Introducción. La creciente demanda de tratamientos en medicina estética para contrarrestar el proceso de envejecimiento de forma segura y efectiva ha conducido a realizar tratamientos que combinan el ácido hialurónico (AH) e inductores de colágeno como la hidroxiapatita cálcica (HaCa) con tecnologías basadas en láseres o fuentes de luz. El objetivo del presente estudio es evaluar los resultados obtenidos empleando la sinergia de un tratamiento de relleno con AH, cuyo agente reticulante es polietilenglicol (PEG), combinado con tecnología de luz infrarroja (IR) en pacientes que desean mejorar la laxitud e hidratación cutánea. Material y método. Estudio preliminar prospectivo en el que se seleccionaron 25 pacientes mujeres, con rango de edad de 37 a 68 años (promedio 48 años), con fototipos I‑IV, que deseaban prevenir y tratar la laxitud cutánea. Para su posterior valoración los pacientes se dividieron en 3 grupos de tratamiento y se analizó la variable satisfacción de forma cualitativa en todos ellos. Tratamiento 1: Formado por 6 pacientes que solo recibieron tratamiento con luz IR. Tratamiento 2: Se trataron 10 pacientes con luz IR más un híbrido de AH no reticulado (18 mg/ml) con HaCa (0,01%). Tratamiento 3: Se incluyeron 9 pacientes que se trataron de modo similar al grupo 2, pero inyectando en la última sesión en el tercio medio malar, un relleno híbrido de AH reticulado (26 mg/ml), HaCa 1%, glicina y L‑prolina. También se tuvo en cuenta si los pacientes eran mayores o menores de 50 años. Resultados. No aparecieron efectos adversos significativos. La satisfacción fue elevada en todos los grupos de tratamiento. De las 25 pacientes que participaron en el estudio, 15 (60%) eran menores de 50 años, obteniendo la mayor satisfacción (100%) las que recibieron el tratamiento 3. El 40% (10 pacientes) eran mayores de 50 años, alcanzando la mayor satisfacción (100%) las que recibieron el tratamiento 1. Conclusión. El tratamiento con luz IR en 5 sesiones, solo o combinado con AH estabilizado y con híbridos de AH e HaCa, es eficaz en el tratamiento de la laxitud cutánea alcanzando resultados muy satisfactorios con pocos efectos adversos.
Community Support for Sustainable Tourism Strategies is an Important Factor in its Successful Development
Authors:   “Aleksander Moisiu” University, 23 Currila, Durres, Albania, Draçi Parashqevi , Kraja Gentiana ,   “Aleksander Moisiu” University, 23 Currila, Durres, Albania
Published: July 2023

This study aims to examine the support of the community in the area of Saranda and Ksamil for sustainable tourism, as one of the most important industries on which the growth of its well-being is based. The reasoning focuses on the sociological tradition
The Evaluation of Financial and Accounting Information, Influencing Factor in Optimizing Managerial Decisions
Authors:   Valahia University of Targoviste, Doctoral School, PhD Student, No. 2 Carol I Bd., Dambovita, Romania, Ionescu Haralambie Cristina Mihaela , Haralambie George Alin ,   Faculty of Economic Sciences, Petroleum-Gas University of Ploieşti, Bd. Bucureşti 39, 100680, Ploieşti, Romania
Published: July 2023

During the economic evolution, the functionality of accounting ranks it among the main information and decision support systems, being a presentation and modeling reference for an economic entity. Starting from the idea that accounting information represe
Student Perspective on Teaching and Learning in Real Science and Humanities: A Comparative Study
Authors:   Petroleum-Gas University of Ploiesti, Ghiță Iulia Adelina
Published: July 2023

A current issue is the finality of education. Many teachers in pre-university education limit themselves in the instructive-educational process to strictly following the school programs, creating personal portfolios, and omitting to pay attention to the quality of the process itself. The relationship between the three types of curriculum taught-learned-evaluated- raises an alarm signal regarding the informational baggage that students are left with at the end of a lesson, a cycle, or a level of schooling. Currently, education aims to achieve the educational ideal which presupposes: “the free, integral, and harmonious development of the human individual, in the formation of an autonomous personality and the assumption of a system of values necessary for personal fulfillment and development, for the development of an entrepreneurial spirit, for active citizenship participation in society, for social inclusion, and employment on the labor market” (LEN no.1/2011, art. 2, para.3). In this sense, it is necessary to reconsider the role that teachers hold in the development of an individual who conforms to the desired societal model. Moreover, the perception that students have concerning certain subjects is projected onto the teacher's image.
Pharmacists' Perspectives on the Implementation of e-Prescribing in Hospitals and Community Pharmacies: A Literature Review
Authors: Zaini Muhammad , Muliyani Muliyani , Isnani Nazhipah , Husin Husin
Published: July 2023

Electronic Prescribing is a system that utilizes information technology to replace or reduce the use of paper prescriptions in the process of prescribing medication to patients. The implementation of e-Prescribing poses significant challenges related to user readiness, facilities, and other factors. This study aims to determine the perspectives of hospital and community pharmacists on the implementation of e-Prescribing. The research design used in this paper is a literature review. The objects used in this study were taken from the results of research published in national and international journals. Articles were obtained from PubMed and Google Scholar using the keywords "Pharmacists" AND "Electronic prescribing" AND "Hospital". A total of 80 articles from PubMed and 280 articles from Google Scholar were obtained. The selection resulted in 6 articles that met the inclusion and exclusion criteria for use in this study. 
Based on the literature review of the 6 journals, information was obtained that the implementation of e-Prescribing from the perspectives of hospital and community pharmacists provides benefits in terms of ease of use, improving patient safety, speeding up service processes, and improving the quality of medication dispensing. Weaknesses identified in the implementation of e-Prescribing are associated with the availability of supporting facilities, skills and readiness of human resources, as well as the continued risk of medication errors.
Identification of Potential Flavonoids against the Spleen Tyrosine Kinase to Treat Psoriasis: In Silico approach
Authors: Pol Sagar , Kadam Vilasrao , Jagtap Sujata , Bhosale Sampada , Pawar Nita , Gaikwad Ravindra
Published: July 2023

Now a day, phytochemicals are widely consideration for structure optimization programs which focuses on making more active and less toxic drug products. Psoriasis is an inflammatory, chronic, remitting and relapsing, genetically influenced skin disease. Variety of flavonoid structureswere used to find the potential molecules against the psoriasis. In this current study molecular docking studies were carried out to identify the flavonoids having good binding ability with the target protein of psoriasis. Docked ligands were subjected to identify the drug like properties using drug-likeness prediction. Findings suggested that 23 flavonoid structures may act against the psoriasis.
Microsphere as Drug Delivery System: An Overview
Authors: D. Gidde Nikita , D. Raut Indrayani
Published: July 2023

Microspheres are mainly free flowing powders consisting of proteins or synthetic polymers. Proteins or synthetic polymers are biodegradable in nature. Microspheres having a particle size less than 200 micrometer. Microspheres are novel drug delivery system which has several benefits over conventional multi dose therapy. There are various approaches in delivering a therapeutic agent to the specific targeted site in a sustained controlled release fashion. Microsphere is act as carriers for drugs. Microspheres received much attention for prolonged release as well as for targeting of anticancer drug to the tumour. In this drug delivery, drug dispersed throughout the particle i.e., the internal structure is a drug matrix and polymeric excipients. It is the reliable means delivery of the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest without untoward effects. In future microspheres will find an appropriate place in novel delivery by combining various new strategies, particularly in diseased cell sorting, diagnostic, gene and genetic materials, safe, targeted and effective in vivo delivery. The current aim of this review is to study the various aspects of microspheres drug delivery system including advantages, disadvantages, types of microspheres, methods of preparations, Evaluations and Applications of microspheres.
A Short Review on Organ-on-a-chip Technology
Authors: A. Marnoor Suresh
Published: July 2023

Organ-on-a-chip (OOAC), also known as microphysiological systems or 'tissue chips' (the names are interchangeable), have gained a lot of attention in recent years because of their ability to provide information at different phases of the drug development process. This cutting-edge technology could help researchers better understand normal human organ function and disease pathology, as well as forecast the safety and efficacy of experimental medications in humans. As a result, they are expected to be beneficial supplements to standard preclinical cell culture methods and in vivo animal research in the near future, and possibly even replacements in the long run. This article presents an overview of this rapidly expanding technology.
Ipnmicrospheres for Controlled Drug Delivery: An Overeview
Authors: Ikbal Abedin Jafar , Sheeba Fr.
Published: July 2023

Oral modified or controlled dosage forms have always been validated to be a more effective opportunity than conventional or immediate release dosage forms. Controlled or modified drug transport systems provide several benefits of delivering a drug to the body in a specific way to reduce its undesirable side effects and maximize its profit. It also improves the therapeutic efficacy of the drug, decreases toxicity, and with better patient compliance and convenience. In the beyond few decades, microspheres have promised targeted or controlled delivery of drugs in the body which proved to be higher than the conventional drug delivery. It also used to deliver drugs, vaccines, antibiotics, and hormones in a controlled way. Interpenetrating polymer networks have gained a lot of interest in drug delivery systems due to their ease of modification during their synthesis and development state, which evolved novel physicochemical and mechanical properties within the formulation. Interpenetrating polymer network (IPN) systems use novel polymers which are synthesized through the interlacing of two independent polymers in a cross-linked form. The polymers used to formulate an IPN system are independently cross-linked or cross-linked to each other. The present review aims to summarize the IPNmicrospheres systems in terms of their merits, classification, mechanism, method of formulation, evaluation and recent advances in the research field of IPN microspheres.
Analysis of Climate Change Management and its implications on Agriculture Tourism in India with reference to genetic diversity in banana
Authors: Krishnakumar Dr. S.
Published: July 2023

The study deals with the productivity in banana to changes in climate and its associated factors. The production and the condition for growth of banana varieties and various produces are vital for growth and development of Agriculture tourism in India. On the other hand, management of climate change and its impacts, and conditions are analyzed using authentic secondary data. The management methods differ from various regions according to climatic condition. The banana cultivation in tropical region is ideal for more income to the farmers. An anecdote of South Africa is included to have a comprehensive overview of the topic undertaken and for a comprehensive and comparative understanding for Indian context. The conditions of climate change and factors like soil type, region and area identified for determining the effect on banana production due to changes in climatic factor are also mentioned therein. To identify an appropriate adaptation strategy and in managing climate justice associated factors are considered and a SWOT Analysis is performed. The variation owing to productivity of banana is also interpreted. When the environmental condition does not suit the yield and appropriate adaption techniques to be followed either by organic agricultural practices or technology driven climate management production orientation. Lastly even change in methods of production and towards optimisation of banana produce, can mitigate the challenges to bio-diversity. Finally, this study is another attempt in offering categorized suggestion to various sections of the society towards growth of Agriculture tourism in the India context