bluuebunny/crossref_metadata_2025 huggingface dataset:
Esthetics using monolithic zirconia and hand-layered zirconia fixed partial denture
Authors:   Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India, Vaishali S
Published: August 2022

Edentulism and dental disease have a major effect on the standard of lifetime of patients. Fixed partial dentures have become the treatment of choice for many people for the replacement of edentulous space in the oral cavity. Therefore, it is of interest to correlate and compare the esthetics between monolithic zirconia and hand layered zirconia among fixed partial dentures in Saveetha Dental College. 100 patients who monolithic zirconia and hand layered zirconia had fixed partial dentures were included within the study. Pink and white esthetic scores were evaluated. Data collected were entered in SPSS and analyzed through Chi square test. It was observed that hand layered zirconia have better white esthetic score (p<0.000) and pink esthetic score (p<0.003) when compared to monolithic zirconia fixed partial dentures, which were statistically significant. It was concluded that hand layered zirconia fixed partial dentures have better esthetics than monolithic zirconia fixed partial dentures.
Antimicrobial, antioxidant and anti-inflammatory activities of seeds from emblica officinalis (Gaertn.)
Authors:   JSS Academy of Higher Education and Research, Mysuru, Karnataka 570 015, India, G Singh Pooja
Published: August 2022

There is a shred of evidence to suggest that Emblica officinalis Gaertn, the botanical name for amla seeds, has greater medicinal potential than amla fruit. We conducted this work to assess the anti-inflammatory, antibacterial, and antioxidant capacities of E. officinalis seed extracts. The bioactive components from the seeds were fractionated using chloroform, hexane, methanol, and diethyl ether, according to the polarity of the solvents. The total amount of phenolic and flavonoid was estimated. Both the reducing power and antioxidant capacities of the extracts were evaluated using the DPPH (1,1-diphenyl-2-picryl-hydrazyl) technique. 15-lipoxygenase (LOX) was inhibited by seed extracts at doses ranging from 5 to 25 micrograms. In silico docking was employed to assess the results. Some human pathogenic microorganisms were tested for their antibacterial activity using the agar disc diffusion method. Escherichia coli, Proteus vulgaris, and Klebsiella pneumonia were inhibited by a methanolic extract with an IC50 value of 58g, making it the most common organic solvent extract. Methanolic extracts also showed good antioxidant and antibacterial activity. Our investigation led us to discover that amla seeds have anti-inflammatory, antioxidant, and antibacterial effects.
Molecular docking analysis of melamine with nuclear factor erythroid 2-related factor 2 and succinate dehydrogenase
Authors:   Department of Biotechnology, Mohanlal Sukhadia University, Udaipur, Rajasthan, India, Rai Nitish
Published: August 2022

Melamine consumption causes oxidative stress by an unknown mechanism. Therefore, it is of interest to analyze the interaction of melamine with two important proteins involved in oxidative stress biology namely, nuclear factor erythroid 2-related factor 2 and succinate dehydrogenase. The molecular docking data shows the melamine binding with these two proteins at critical residues. These interactions can be logically perceived for the causation of melamine induced oxidative stress.
Nikitin's apartment buildings in Chita
Authors: Figol Dmitry Dmitrievich , Bazilevich Mikhail Evgenevich
Published: August 2022

The article reflects the results of the research conducted within the framework of the scientific project "Architects and engineers of the eastern suburbs of Russia (the second half of the XIX – beginning of the XX century)". The publication examines the creative activity of the famous Trans-Baikal architect, a graduate of the St. Petersburg Imperial Academy of Arts Gavriil Vlasevich Nikitin, who worked in Chita at the beginning of the XX century. Brief biographical information is provided concerning the educational training of the architect, as well as his professional activities on the "outskirts" of the Russian Empire. On the basis of archival data and materials of field surveys, seven preserved buildings of apartment buildings built in the capital of Transbaikalia according to his projects have been identified. A brief digression into the history of the construction of these facilities is given, their spatial planning and stylistic features are considered. Apartment houses authored by G. V. Nikitin are of unconditional interest for historical and architectural science not only as examples of regional architecture of the pre-revolutionary period, but also as an example of the work of this master on a private order. Carrying out projects for representatives of the Chita merchant class, the architect managed to create a number of expressive structures that met the socio-economic and aesthetic needs of his time, as well as set the tone for the subsequent development of the central district of the city. The study showed that the architect mainly worked in the forms of eclecticism, skillfully combining motifs and elements of different architectural styles, thereby managing to form his own, well-recognized author's handwriting.
Forced suction thrombectomy in patients with acute ischemic stroke using the SOFIA Plus device
Authors: Roh Hyun Ki , Ju Min-Wook , Byoun Hyoung Soo , Park Bumsoo , Park Kwang Hyon , Lim Jeongwook
Published: August 2022

Objective: Stent retrieval thrombectomy has recently been the standard treatment for acute ischemic stroke with large artery occlusion. However, the development of catheters for suction thrombectomy has recently led to results comparable to that of stent retrieval thrombectomy (SRT). This study aimed to analyze the safety and efficacy of forced suction thrombectomy (FST) using the SOFIA Plus (MicroVention Terumo, Tustin, CA, USA) device.Methods: We included patients with acute ischemic stroke who underwent FST using the SOFIA Plus device at our institution. Medical records and angiographic data were reviewed, and the results of this study were compared with those of other FST studies.Results: A total of 35 patients were included in this study. The occlusion sites were the internal carotid artery terminal (4), M1 segment (20), and posterior circulation (11). Of the 35 patients, FST was performed in only 21 (60%) patients, and the remaining 14 (40%) patients underwent SRT and FST. In all cases, the recanalization rate was 100%, and the average time from groin puncture to recanalization was 21±4.94 min. In particular, the average time required to reach the SOFIA Plus lesions from the groin puncture was 10.44±5.06 min and about 67% of the FST patients were recanalized at the first attempt. Three-months modified Rankin Scale (mRS) score of ≤2 was observed in 52% of the patients.Conclusions: Forced suction thrombectomy using the SOFIA Plus yielded a high recanalization rate within a shorter time. In particular, the recanalization rate was higher than that reported in previous studies using other types of suction devices.
Outcome of Local Corticosteroid Injection by Ultrasound- versus Palpation-Guided Technique in Plantar Fasciitis
Authors: Mishra Shalini , Handa Gita , Gamanagatti Shivanand , Wadhwa Sanjay , Singh Upinderpal
Published: August 2022

Background: Plantar fasciitis is a common cause of heel pain. Conservative treatment is often effective, but in many cases, invasive procedures may be required. Local corticosteroid injection is the most frequently used invasive technique and can be given under ultrasound (USG) or palpation guidance. We sought to compare the outcome of local corticosteroid injection by USG and palpation guidance in plantar fasciitis.

Methods: This was a prospective randomized study of patients who presented with heel pain between July 2015 and November 2016 and were screened for plantar fasciitis by USG. Patients with confirmed plantar fasciitis were managed conservatively for 4 weeks. The 60 consecutive patients not responding to the conservative treatment were randomized into two groups. Group A (n = 30) received a corticosteroid injection under USG guidance. Group B (n = 30) received a corticosteroid injection under palpation guidance. Patients were followed up at 3 and 6 weeks. We compared the visual analog scale score, plantar fascia thickness, and heel pad thickness in both groups.

Results: There was significant pain relief in both groups after 3 and 6 weeks of local corticosteroid injection, with greater relief noted in the USG-guided group. There was a significant decrement in plantar fascia thickness in both groups after 3 and 6 weeks; however, a greater decrement was observed in the USG-guided group. Neither group showed a significant difference in heel pad thickness after 3 and 6 weeks.

Conclusions: Ultrasound-guided injection provided better pain relief and a greater reduction in plantar fascia thickness than palpation-guided injection.
Patient-Reported Outcomes of Minimally Invasive Distal Linear Metatarsal Osteotomy for Hallux Valgus
Authors: Seki Hiroyuki , Suda Yasunori , Takeshima Kenichiro , Nagashima Masaki , Ishii Ken
Published: August 2022

Background: Modified Bösch osteotomy, or distal linear metatarsal osteotomy (DLMO), is one of the minimally invasive correctional operations for hallux valgus deformity. Although the clinical and radiographic results of DLMO have been previously shown, the relationship between clinical outcomes using a validated patient-reported outcome measure and radiographic corrections have yet to be evaluated.

Methods: A total of 70 patients (97 feet) treated at our hospital were included in the study. The Self-Administered Foot Evaluation Questionnaire (SAFE-Q) and radiographic data were evaluated at a minimum 1-year follow-up.

Results: Scores of all five SAFE-Q subscales showed a statistically significant improvement: pain and pain-related (from 63.3 to 86.6), physical functioning and daily living (from 81.3 to 92.7), social functioning (from 79.5 to 94.4), shoe-related (from 43.1 to 72.3), and general health and well-being (from 67.7 to 92.1). The mean hallux valgus angle improved from 39.1° to 9.3°, and the mean intermetatarsal angle improved from 16.6° to 7.0°. Recurrence and hallux varus at the final follow-up occurred in nine feet (9.3%) and 15 feet (15.5%), respectively. Four of the five SAFE-Q subscale scores improved significantly even in patients with hallux varus.

Conclusions: Distal linear metatarsal osteotomy improves foot-related quality of life in patients with hallux valgus deformity despite of the high rate of postoperative radiographic complication, especially hallux varus. Patients might be willing to tolerate mild hallux varus after DLMO, as indicated by patient-centered clinical results.
Pneumococcal genetic variability in age-dependent bacterial carriage
Authors: Kremer Philip HC , Ferwerda Bart , Bootsma Hester J , Rots Nienke Y , Wijmenga-Monsuur Alienke J , Sanders Elisabeth AM , Trzciński Krzysztof , Wyllie Anne L , Turner Paul , van der Ende Arie , Brouwer Matthijs C , Bentley Stephen D , van de Beek Diederik , Lees John A
Published: August 2022

The characteristics of pneumococcal carriage vary between infants and adults. Host immune factors have been shown to contribute to these age-specific differences, but the role of pathogen sequence variation is currently less well-known. Identification of age-associated pathogen genetic factors could leadto improved vaccine formulations. We therefore performed genome sequencing in a large carriage cohort of children and adults and combined this with data from an existing age-stratified carriage study. We compiled a dictionary of pathogen genetic variation, including serotype, strain, sequence elements, single-nucleotide polymorphisms (SNPs), and clusters of orthologous genes (COGs) for each cohort – all of which were used in a genome-wide association with host age. Age-dependent colonization showed weak evidence of being heritable in the first cohort (h2 = 0.10, 95% CI 0.00–0.69) and stronger evidence in the second cohort (h2 = 0.56, 95% CI 0.23–0.87). We found that serotypes and genetic background (strain) explained a proportion of the heritability in the first cohort (h2serotype = 0.07, 95% CI 0.04–0.14 and h2GPSC = 0.06, 95% CI 0.03–0.13) and the second cohort (h2serotype = 0.11, 95% CI 0.05–0.21 and h2GPSC = 0.20, 95% CI 0.12–0.31). In a meta-analysis of these cohorts, we found one candidate association (p=1.2 × 10-9) upstream of an accessory Sec-dependent serine-rich glycoprotein adhesin. Overall, while we did find a small effect of pathogen genome variation on pneumococcal carriage between child and adult hosts, this was variable between populations and does not appear to be caused by strong effects of individual genes. This supports proposals for adaptive future vaccination strategies that are primarily targeted at dominant circulating serotypes and tailored to the composition of the pathogen populations.
Experimental design for the optimization of dry-pressed ceramic bricks (Dry-Press)
Authors:   Escuela Superior Politecnica de Chimborazo (ESPOCH) Ecuador, Guamán Lozada D. , Rodríguez Pinos A. ,   Escuela Superior Politecnica de Chimborazo (ESPOCH) Ecuador, Santiana C. ,   Escuela Superior Politecnica de Chimborazo (ESPOCH) Ecuador, Yyuquilema B.
Published: August 2022

One of the most common products in the construction industry is brick due to its advantages over other building materials such as blocks. In developing countries like Ecuador, brick is handcrafted and is the source of income for thousands of families. These bricks lack a systematized process that optimizes resources to make a brick that meets local regulations. This study evaluates the use of the different raw materials used in production through experimental designs to determine the amount of optimal components locally available (“White Clay,” “Black Clay,” “Water”) and achieve the maximum compressive strength in dry-pressed ceramic bricks. This research also identifies the behavior of the compressive strength based on the compaction pressure in the molding stage, concluding that the model that best fits the behavior is a quadratic model, and from the trace plot, it was observed that compared with “White Clay,” “Black Clay” contributes further to the brick strength. The optimal amount of components to meet the 6 MPa pressure standard required in the brick was 5% water, 85% “Black Clay” and 10% “White Clay.” The pressure value required in the compaction stage was 4.9Mpa (712psi,) and greater strength can be achieved by only adding “Black Clay” and water.
Hepatic Artery and Portal Vein Variations using Contrast Enhanced Computed Tomography Abdominal Angiography
Authors: Sambath Pugazhendhi , Padmanaban Elamparidhi , Amirthalingam Umamageswari , Anand AM , Sudhakar Pitchumani , Dhinadhayalan Rajasree , George Rintu , Danassegarane Rekha
Published: August 2022

Introduction: Normal hepatic vascular anatomy and its variants carry considerable importance during liver transplants, laparoscopic surgeries, penetrating abdominal trauma, and radiological abdominal interventions. The occurrence of iatrogenic hepatic vascular injury increases in case of atypical anatomy and variations. Aim: To determine the prevalence of common hepatic artery and portal vein variants by using Multidetector Computed Tomography (MDCT). Materials and Methods: This is a hospital based retrospective study done in Sri Mankula Vinayagar Medical College and Hospital, Puducherry, India, between July 2019 and July 2020. The Contrast Enhanced Computed Tomography (CECT) abdominal angiography of 350 patients was taken for the study. The MDCT abdominal angiography was performed using 16 slice PHILIPS MX16 CT scanner with intravenous administration of non ionic iodinated contrast, having iodine content of 300 mg/mL at the dosage of 1.5 mL/kg body weight, using automated pressure injector at a rate of 3.5 mL/sec. Arterial phase and portal venous phase images were obtained at 25 and 55 seconds respectively. The hepatic artery anatomical types were classified according to Michel's classification and the portal vein according to Covey AM et al., classification. Data obtained was entered in EPI INFO version 7.2.1.0 and analysed using Statistical Package for the Social Sciences (SPSS) software version 24.0. Results: Hepatic artery proper (right and left hepatic arteries arising from common hepatic artery) (Type I) was seen in 222 (63.4%) of cases. The most common variant was replaced Left Hepatic Artery (LHA) from the left gastric artery (Type II) with a prevalence of 46 (13.1%). A normal portal vein branching pattern (Type I) was seen in 201 (57.4%) of cases. The most common variation was trifurcation (Type II) with a prevalence of 68 (19.4%). Conclusion: Knowledge about normal hepatic artery, portal vein, and its variants is important in hepatic interventions and CT angiography is the modality of choice for evaluating the vascular anatomy.
Incomplete Hippocampal Inversion in Normal Individuals- A Retrospective Observational Study using Magnetic Resonance Imaging
Authors: Govardhanan . , Vasanthan S Ratna , Rajarajan . , Jawahar .
Published: August 2022

Introduction: Hippocampal inversion is a normal process that happens between 11 and 21 weeks of gestation. In some individuals the process is incomplete and is termed as Incomplete Hippocampal Inversion (IHI). There are differing observations recorded, of its incidence in normal individuals- from as high as 17% to nil making it difficult to come to a conclusion as to whether IHI is a normal anatomical variant or a marker of a wide spread disorder in brain. Aim: To determine the incidence of IHI in the hippocampus of individuals who don’t suffer from any form of epilepsy and for whom Magnetic Resonance Imaging (MRI) brain has been performed and seen to be normal. Materials and Methods: A retrospective observational study was conducted in a tertiary centre using T1fl 3D, check globally isovoxel 0.86 mm images of the brain and incidence of IHI in normal individuals without seizures for whom MRI brain was normal otherwise was calculated. The MRI images of a total of 197 individuals qualified for the study. Analysis was done by four Radiologists using subjective visual criteria. results: It was seen that 1.015-1.52% was the incidence of IHI in otherwise normal MRI brain in present study. A 1.52% is the incidence placing a study classified as partial IHI under IHI and 1.015% not placing it under IHI. All were unilateral, on left side. conclusion: The results of present study point that there was very less incidence of IHI in normal individuals. Such a less incidence will make it difficult to suggest that IHI is a normal anatomical variant. Present study also encountered potential pitfalls with the use of T1 weighted 3 Dimensional (3D) images to determine of presence or absence of IHI.
Role of HRCT in Assessing Requirement of Oxygen for COVID-19 Patients: A Retrospective Study from Amalapuram, Andhra Pradesh, India
Authors: Akshay B , Krishna A Bala , Karthik Padala , Srujana Pathuri Venkata
Published: August 2022

Introduction: Coronavirus Disease 2019 (COVID-19) infection has affected many countries in the world with its high rate of infectivity and created havoc with its mortality rate. A High Resolution Computed Tomography (HRCT) thorax scan is useful in detection and to assess the involvement of lung which is helpful to plan the management. Aim: To assess the oxygen requirement in COVID-19 patients based on the lung involvement using HRCT scan. Materials and Methods: A retrospective study was conducted from 1st May to 30th June 2021 in the Department of Radiodiagnosis, Konaseema Institute of Medical Sciences and Research Foundation, Amalapuram, Andhra Pradesh, India. HRCT thorax scans of 600 patients with COVID-19 infection were included. The patients were categorised based on their lung involvement into three groups (mild, moderate, severe) and then they were followed-up for the oxygen support that each patient received during their stay in hospital. Results: Among the 184 mild COVID-19 infection cases none required Bilevel Positive Airway Pressure (BiPAP)/ intubation. Sixty four out of 340 moderate COVID-19 infection cases required BiPAP and intubation and 28 out 76 severe COVID-19 infection cases required BiPAP and intubation. None in mild cases, 60 (17.6%) in moderate cases, and 32 (42.1%) in severe cases had mortality. The rate of oxygen support and risk of intubation increased as the score increases (p<0.001). The Computed Tomography Severity Index (CTSI) also showed significant difference with the age and co-morbidities of the patients (p<0.01). Conclusion: The HRCT is helpful in assessing the requirement of oxygen support in COVID-19 patients and to plan the management. There is increased non invasive and invasive ventilatory support along with increased morbidity and mortality as the score increases.
Spectrum of Congenital Malformations and Associated Factors: A Cross-sectional Study from Eastern India
Authors: Ghosh Tarapada , Das Sumanta , Mohanta Mahesh Prasad , Khuntdar Bidyut Kumar
Published: August 2022

Introduction: Congenital malformations are important contributors for neonatal and infant mortality after prematurity, intrapartum complications and infections. Aim: To find out the prevalence and pattern of congenital malformations among the live born neonates in study area as well as to identify the associated risk factors. Materials and Methods: This descriptive hospital based cross- sectional study was carried out in 305 cases at Midnapore Medical College, Medinipur, West Bengal, from July 2016 to June 2017. All live inborn neonates were assessed for the presence of any malformation(s). The still born or out born babies were excluded. Congenital malformations were diagnosed by clinical examination as well as imaging studies. Data regarding risk factors were collected from the history and the case records. Chi-square test was done to find out the significance of the risk factors. Results: During the study period, there were 14240 live births, out of which 305 cases of congenital malformations were noted. Prevalence of congenital malformations was 214.1 per 10,000 live births or 2.14%. Out of 305 cases, 165 (54.10%) were males, 137 (44.92%) were females, and 3 (0.98%) had ambiguous genitalia. Prevalence of malformations was not significantly different between primi and multipara mothers, and for the different socio-economic backgrounds. A higher prevalence of congenital malformations in mothers above 30 years, consanguinity, low birth weight and prematurity were observed. History of abortion and still birth were associated with higher prevalence. Polyhydramnios, pregnancy induced hypertension and previous abortion and still birth were also associated with higher prevalence of malformations. Musculoskeletal system was majorly involved in 92 (30.16%) cases, followed by central nervous system 48 (15.74%). Conclusion: Prevalence of congenital malformations was found to be 214.1 per 10,000 live births or 2.14%. Maternal age >30, consanguinity, prematurity and low birth weight were associated with increased prevalence of congenital malformations. Musculoskeletal system was the most commonly involved system.
Analysis of Profitability Determinants and Effect Value of Automotive Companies in Indonesia
Authors: Noor Salim Sulistiyani,
Published: August 2022

The study analyzes the financial performance of automotive companies' firm value on the Indonesia Stock Exchange. The financial performance is DER, CR, and company size. The secondary data was a company report, which is eight companies. The panel data regression using Eviews 11.0 to analyze hypotheses. The finding of the t-test of the DER, CR and Firm size negatively and significantly affect profitability; therefore, profitability on firm value has no significant impact. Partially DER positively affects firm value; CR and size have no significant effect on firm value. Profitability as a mediating increases the impact of DER, CR, and firm size on firm value. CR, and firm size, have a positive and significant effect on firm value. The Company should pay attention to the liquidity ratio because the most influential in reducing profitability in the future. Therefore, the investors must check the company's cashflow in order to understand company's liquidity level.
Research on License Plate Recognition Method Based on HALCON
Authors: Wang Song
Published: August 2022

With the rapid development and continuous improvement of image processing technology, the intelligent management of traffic management system for vehicles has accelerated the speed of road safety information, in which the car license plate as the identification of vehicle identity, the identification of its character information is the key to the license plate recognition system. In order to solve the problem of the traditional license plate recognition algorithm such as long development period, this study adopts the HALCON as a programming platform, the acquisition of image preprocessing to enhance image contrast, through the affine transformation to complete correction of tilt of the image, and at the completion of the design after character segmentation OCR based on neural network classifier to complete accurate recognition of Chinese characters, letters and Numbers. The experiment shows that the system has the ability to adapt to the environment and can recognize the license plate information efficiently and accurately.
Study of Insulin Hormone Level and β-Cell Function in Children with β-Thalassemia Major
Authors: AbdElkawy Marwa Mohamed Nabil , Elrifaey Shaymaa Mohamed , Mabrok Maaly Mohamed , Badraia Ebrahim Mohamed
Published: August 2022

Background: Diabetes and Impaired Glucose Tolerance are amajor complication of iron overload in patients with beta thalassemia major.

Aim: To study the serum level of Insulin hormone and beta cell function in β- Thalassemia major patients.

Methods: This study was carried out on 50 children that were divided into:- Group (1): thirty child with beta thalassemia with age ranged between (5 to 10 years), Group (2): Twenty apparently healthy matched age children were also included as control group. Both groups were subjected to history taking, full clinical examination, anthropometric measures, laboratory investigation that included:-, complete blood picture, Serum iron, serum ferriten,fasting serum glucose, 2h postprandial serum glucose, fasting serum insulin by ELISA(Sandwish assay procedure.) IRI, BFI.

Results: There was highly statistical significant difference between the patient and control groups in the insulin resistance index (IRI), but there was decrease in beta cell function index (BFI) in patients group with no significantdifference.

Conclusion: Thalassemic child is at risk of IR which is responsible for abnormalities in glucose metabolism so proper management and regular follow up is necessary to early diagnosis and prevention of complications.
Synergistic Activities of Ethanolic Extracts of Jatropha tanjorensis Leaves in Conventional Management of Rheumatoid Arthritis in the Ankles of Wistar Rats
Authors: Ozoemena Chiadikobi Lawrence , Egwuatu Ifeanyi Anthony , Ojiakor Vivian Onyinye , Ozor Christian Chiemeka , Ozor Ignatius Ikemefuna , Akpa Anthony Okechukwu
Published: August 2022

Background: Rheumatoid arthritis (RA) is a common cause of chronic inflammatory joint disease. Plant extracts contain several bioactive factors which can re-establish the homeostasis of joints and joint cartilages.

Objectives: This study aim to evaluate the synergism of ethanolic extracts of Jatropha tanjorensis leaves with Ibuprofen and Sulfasalazine as an antirheumatic agent.

Methodology: 45 adult male Wistar rats were subjected to different types of treatment; A: Positive control, B: Low dose of extract only, C: Medium dose of extract only, D: High dose of extract only, E: Ibuprofen and Sulfasalazine only, F: Ibuprofen, Sulfasalazine and Low dose of extract, G: Ibuprofen, Sulfasalazine and Medium dose of extract, H: Ibuprofen, Sulfasalazine and High dose of extract, I: Normal control. Groups A-H were collagen-induced arthritic (CIA) models. One week before sacrifice, anterior-posterior and lateral diameters of both ankles, physical appearance and weight were assessed. After sacrifice, histological analysis of ankles using modified Mankin scoring system was done.

Results: Groups F-H exhibited significant results in direct proportion to the dosages of J. tanjorensis extract administered and the combination of drugs. Increased doses slowed down the progression of cartilage destruction evidenced by prevention of joint swellings and preservation of chondrocytes and its histological features, while treatement with different dosages of the extract only was found to be unremarkable.

Conclusion: The result indicate that the plant extract could enhance current treatment options of rheumatoid arthritis. The physical appearance, assessment of weight, anterior-posterior and lateral diameters, and histological examination of both ankles of the animal confirms the assumptions of Jatropha tanjorensis in management of rheumatoid arthritis.
Biocontrol Activity of Yeasts against Alternaria solani and Plant Growth Promotion of Tomato Plants
Authors: Ashiwini G. , Mallesha B. C.
Published: August 2022

Aim: Yeasts have emerged as a single celled biocontrol agent which are applicable in controlling many disease causing pathogens in plants. These yeasts also have growth promoting substances that help in the growth and development of plants.

Materials and Methods: Yeast on tomato plants were isolated using standard plate count technique and observed under microscope for their cell shape and sizes. Biocontrol activity of yeast was evaluated by measuring diameter of zone of inhibition (mm) and estimating mycelial dry weights of pathogen. IAA production by yeasts was estimated in vitro and the plant growth and development was evaluated by measuring plant heights, number of leaves, number of days for flower initiation, shoot biomass, root mass, disease incidence and severity in pot culture experiments.

Results: Yeast isolate TPL-I isolated from tomato plants was most effective in inhibiting Alternaria solani with diameter of zone of inhibition of 9.00 mm. Reduced mycelial dry weight of pathogen viz., 40.07 mg was exhibited by TPL-I under in vitro conditions. The maximum concentration of IAA was produced by TPL- I (0.11 μg/ml). The highest plant height, number of leaflets and number of days taken for flower initiation was recorded highest in T4 (Trichoderma harzianum) followed by T7 (Foliar spray of Alternaria solani + TPL- I + Trichoderma harzianum) at 30, 45 and 60 days after transplanting. Maximum dry weight of shoot (12.32 g/plant) and root (5.18 g/plant) was recorded in T4 (Foliar spray of Trichoderma harzianum) whereas, minimum dry weight of shoot (8.26 g/plant) and root (2.80 g/plant) was recorded in T2 (Foliar spray of Alternaria solani). Lowest disease incidence (33.33%) and disease severity (24.25%) was recorded in T5 (Foliar spray of Alternaria solani + TPL- I).
Effects of Aqueous and Methanol Extracts of Cocos nucifera (Coconut) Milk on Testosterone Level and Testes of Male Albino Rats
Authors: Onyemelukwe Anulika Obianuju , Nweze Chidera Queen
Published: August 2022

Aims: This study was designed to investigate the effect of aqueous and methanol extracts of Cocos nucifera (coconut) milk on the testosterone levels and testes of male albino wistar rats.

Study Design: A 15-day experimental study.

Place and Duration of Study: Animal House and Department of Medical Laboratory Science, College of Medicine, University of Nigeria, Enugu Campus, between May 2019-November 2019.

Methodology: Twenty five adult male albino rats were divided into five groups (I-V) of five rats each. Rats in group I received only water and standard feed throughout the experiment and served as control. Groups II and III received 163mg/kg and 326mg/kg of methanol extract of coconut milk (MECM) respectively, while group IV and V received 110mg/kg and 220mg/kg of aqueous extract of coconut milk (AECM) for two weeks. Upon completion of extract administration, the blood samples of the rats were obtained by a retro-orbital puncture of the median canthus for estimation of serum testosterone. The animals were sacrificed and the testes excised, weighed and fixed in 10% formal saline for 48hours prior to paraffin embedding for histological processing. Testes sections were processed and stained using the Haematoxylin and Eosin (H&E) technique for light microscopical examination.

Results: There was no significant difference in the relative testicular weight between the "control" and "treatment" groups following oral administration of MECM and AECM to rats. Similarly, there was no discernible variation in the testosterone levels between the "control" and "test" groups. Testicular histology showed normal seminiferous tubule with mild germinal epithelial sloughing, hence no increased spermatogenesis was observed in the experimental group.

Conclusion: Extracts of Cocos nucifera milk had no significant short term effects on the testicular weight and the testosterone level of male Albino rats. In addition, extracts of Cocos nucifera milk at these doses may cause mild morphological alterations in the testes of rats.
POLA KOMUNIKASI KELUARGA DI MATA GENERASI Z
Authors: Yoanita Desi
Published: August 2022

Relasi orang tua dan anak yang menginjak usia dewasa muda (Gen Z) bisa digambarkan sebagai ‘love and hate relationship’. Ketegangan muncul karena di usia tersebut anak sudah memiliki kesadaran akan kemandirian, sementara orang tua masih menjalankan otoritas penuh atas mereka. Pola Komunikasi Keluarga menggambarkan relasi orang tua dan anak dalam dua bentuk, yaitu conformity orientation dan conversation orientation. Penelitian ini mendeskripsikan bagaimana pola komunikasi diterapkan dalam keluarga 10 informan yang berusia 18-25 tahun. Menggunakan metode studi kasus, Peneliti menganalisis data hasil Focus Group Discussion (FGD) secara tematik dan menghasilkan temuan sebagai berikut: 1) kebersamaan dalam keluarga memerlukan komitmen; 2) setiap keluarga memiliki batasan keterbukaan yang berbeda dan keterbukaan tidak selalu terjadi dua arah; 3) orang tua masih berotoritas atas isu jangka panjang atau yang membutuhkan dana besar; 4) memperlakukan anak sebagai orang dewasa merupakan wujud trust dan penghargaan orang tua; 5) relasi antara orang tua menjadi role model kehangatan dalam keluarga; 6) Ayah menjadi sosok penting dalam menciptakan kehangatan.
STRATEGI KOMUNIKASI PUBLIC RELATIONS DALAM MEMBANGUN BRAND AWARENESS PROGRAM INTERNASIONAL
Authors: Yanti Alice Vitri , Wijaya Lina Sinatra
Published: August 2022

Program Internasional merupakan salah satu cara bagi kebanyakan universitas untuk meningkatkan citra universitas di masyarakat. Tetapi pada kenyataannya banyak mahasiswa tidak mengetahui tentang kegiatan kegiatan yang disajikan oleh biro yang menangani program internasional.  Penelitian ini ingin melihat bagaimana public relations (PR) dari Biro Kerjasama dan Hubungan Internasional (BKHI) Universitas Kristen Satya Wacana (UKSW) dalam membangun brand awareness program internasional dengan menggunakan konsep PDCA (Plan, Do, Check, Act) dan P.E.N.C.I.L.S (Publication, Event, News, Community Involvement, Inform or Image, Lobbying and Negotiation, Social Responsibility) strategy sebagai alat ukurnya. Teknik penelitian ini menggunakan penelitian deskriptif kualitatif dengan metode penelitian studi kasus. Pengumpulan data dilakukan dengan  wawancara dan observasi serta mengumpulkan dokumentasi kegiatan. Hasil dari penelitian ini menunjukkan  strategi komunikasi public relations yang dilakukan  adalah dengan menerapkan PDCA dan P.E.N.C.I.L.S strategi secara konsiten dan bertahap agar seluruh kegiatan yang direncanakan dan akan dilaksankaan dapat menghasilkan hasil yang maksimal  pada program internasional di mahaiswa UKSW. Strategi yang dilakukan adala dengan publikasi secara rutin  melalui berbagai media sosial serta melaksanakan social responsibility dengan melibatkan mahasiswa dari program pertukaran pelajar dari Taiwan dan Jepang untuk mengajar bahasa dan budaya mereka ke Sekolah Dasar (SD) di Salatiga. Dari penelitian ini ditemukan bahwa program internasional BKHI UKSW berada pada posisi brand recognition.
VIVER E TRABALHAR EM TERRITÓRIO OCUPADO: a Palestina e seu povo
Authors: Montenegro Ana Maria Maciel
Published: August 2022

Este artigo analisa de uma perspectiva histórica os diferentes meios jurídicos e administrativos bem como as resoluções de órgãos internacionais na regulação de uma área de disputa entre judeus e palestinos – a faixa de Gaza. A partir de consulta à imprensa e em revistas acadêmicas especializadas a autora revela as dificuldades vividas pelos palestinos na organização da vida e do trabalho, pelos bloqueios de circulação, que os transformam em refugiados em sua própria terra. Ela conclui que esses dispositivos regulatórios sobre o território acabaram fundamentando a desigualdade desses povos perante a lei, negando aos palestinos a aplicação do direito internacional dos povos disporem de si mesmos. PALAVRAS-CHAVE: geografia, organização de território, política internacional, Oriente-médio árabe, conflito.LIVING AND WORKING IN OCCUPIED TERRITORY: Palestine and her people Ana Maria Maciel Montenegro This paper analyzes, from a historical perspective, the different juridical and administrative means as well as the resolutions of international organs in the regulation of a disputed area among Jews and Palestinians – the Gaza strip. Beginning from reading the press and specialized academic magazines the author reveals the difficulties lived by the Palestinians in their organization of life and work, for the restrictions of movement within the Gaza Strip territory, that transform them in refugees in their own land. She concludes that those land regulatory devices ended up fundamenting the inequality of those people before the law, denying the Palestinians the application of the international law according to which people are the owners of their own destinies. KEYWORDS: geography, territory organization, international politics, Arab Middle-East, conflict.VIVRE ET TRAVAILLER EN TERRITOIRE OCCUPE: la Palestine et son peuple Ana Maria Maciel Montenegro Cet article analyse dans une perspective historique les différents moyens juridiques et administratifs ainsi que les résolutions d’organes internationaux pour la régulation d’une zone de conflit entre Juifs et Palestiniens – la bande de Gaza. Une recherche faite dans la presse et dans des revues scientifiques spécialisées permet de montrer les difficultés vécues par les Palestiniens pour l’organisation de leur vie quotidienne et de leur travail, à cause des blocages de la circulation qui les transforment en réfugiés sur leur propre territoire. La conclusion à laquelle on arrive est que ces dispositifs régulateurs sur le territoire ont fini par créer l’inégalité de ces peuples face à la loi, ne permettant pas aux Palestiniens d’avoir recours au droit international qui garantit aux peuples de disposer d’eux-mêmes. MOTS-CLÉS: géographie, organisation du territoire, politique internationale, Moyen Orient arabe, conflit.Publicação Online do Caderno CRH:http://www.cadernocrh.ufba.br
Inercias Y Transformaciones en las Relaciones Laborales del Uruguay
Authors: Pucci Francisco
Published: August 2022

Este trabalho se propõe a analisar a evolução das relações de trabalho no Uruguai, no marco dos processos de reestruturação produtiva que começaram a ser desenvolvidos a partir da constituição de mercados regionais no Cone Sul. A hipótese que sustentamos é de que as transformações no mundo do trabalho produzidas no Uruguai não podem ser atribuídas unicamente à aplicação de um modelo econômico ou social específico de desenvolvimento, mas que estão inscritas em modificações estruturais de longo prazo, associadas a mudanças nas relações sociais produzidas em escala mundial. Contudo, a evolução concreta verificada nas relações de trabalho é explicada pelas características específicas dos processos de integração regional que se expressam na conformação do MERCOSUL. PALAVRAS-CHAVE: MERCOSUL, reestruturação, atores, negociação, trabalho. INERTIAS AND TRANSFORMATIONS IN THE LABOR RELATIONS OF URUGUAY IN THE CORNERSTONE OF THE PROCESSES OF REGIONAL INTEGRATION Francisco Pucci This work intends to analyze the evolution of the labor relations in Uruguay, at the cornerstone of the productive restructuring processes that began to be developed starting from the constitution of regional markets in the Southern Cone. The hypothesis we support is that the transformations in the world of labor ocurred in Uruguay cannot be attributed only to the application of an economical or social model specific to development, but are enrolled in long term structural modifications, associated to changes in the social relations ocurred worldwide. However, the concrete evolution verified in labor relations is explained by the specific characteristics of the processes of regional integration that are expressed in the conformation of MERCOSUL. KEYWORDS: MERCOSUL, restructuring, actors, negotiation, work. INERTIES ET TRANSFORMATIONS DANS LES RELATIONS DE LABEUR EN URUGUAY A L’OCCASION DES PROCESSUS D’INTEGRATION REGIONALE Francisco Pucci Cette étude se propose d’analyser l’évolution des relations de travail en Uruguay, à l’occasion des processus de restructuration productive qui ont commencé à se développer à partir de la constitution des marchés régionaux dans le Cône Sud. L’hypothèse que nous soutenons est que les transformations du monde du travail produites en Uruguay ne peuvent pas uniquement être attribuées à l’application d’un modèle économique ou social spécifique de développement mais qu’elles sont inscrites dans des modifications structurelles à long terme, associées à des changements dans les relations sociales produites à l’échelle mondiale. Cependant l’évolution concrète, que l’on a pu constater dans les relations de travail, s’explique par les caractéristiques spécifiques des processus d’intégration régionale mis en évidence par le MERCOSUD. MOTS-CLÉS: MERCOSUD, restructuration, acteurs, négociation, travail. Publicação Online do Caderno CRH: http://www.cadernocrh.ufba.br
IMPÉRIO E GOVERNO REPRESENTATIVO: uma releitura
Authors: Dolhnikoff Miriam
Published: August 2022

Este artigo analisa o governo representativo no Brasil, no decorrer do século XIX, de modo a apontar como a monarquia constitucional brasileira não se afastou dos modelos de representação política então vigentes na Europa. Com esse objetivo, o artigo examina o Poder Moderador, os critérios de cidadania e a legislação eleitoral. PALAVRAS-CHAVE: governo representativo, monarquia constitucional, eleições, cidadania, poder moderador. EMPIRE OF REPRESENTATIVE GOVERNMENT: rediscussion Miriam Dolhnikoff This paper analyzes the representative government in Brazil, in the closing of the XIX century, so as to show that the Brazilian constitutional monarchy did not stand apart of the models of political representation then effective in Europe. With that aim, the paper examines the Poder Moderador, the citizenship criteria and the electoral legislation. KEYWORDS: representative government,  constitutional monarchy, elections, citizenship, poder moderator. L’EMPIRE DU GOUVERNEMENT REPRÉSENTATIF: une nouvelle lecture Miriam Dolhnikoff Cet article fait une analyse du gouvernement représentatif au Brésil, au XIXe siècle. Il essaie de montrer combien la monarchie constitutionnelle brésilienne ne s’est guère éloignée des modèles de représentation politique en vigueur, à l’époque, en Europe. C’est dans ce but qu’on y étudie le Pouvoir Modérateur, les critères de citoyenneté et la législation électorale. MOTS-CLÉS: gouvernement représentatif, monarchie constitutionnelle, élections, citoyenneté, pouvoir modérateur. Publicação Online do Caderno CRH: http://www.cadernocrh.ufba.br
Coesão e evasão em assentamentos rurais no extremo-sul do Brasil
Authors: Freire Mello Paulo
Published: August 2022

Através de etnografias em dois assentamentos no Rio Grande do Sul, discutiu-se os processos de coesão social e sua potencialidade em estancar a evasão e a rotatividade. Não se encontrou correlação entre a evasão e diversas variáveis relacionadas à dimensão material em 193 assentamentos. A adoção da perspectiva da sociologia da crítica, de Boltanski, em associação com aportes pontuais de Bourdieu, Wolf e Elias, permitiu compreender os processos de mobilidade e de construção da coesão social dos assentados. Esta é relacionada à reciprocidade, em especial, ao parentesco e às relações religiosas e de vizinhança. Verificou-se que os assentados, cada vez mais situados na cidade doméstica, estão construindo processos corporativos, ainda que de forma negociada com o MST, INCRA e vizinhança.
COVID-19 Disease Severity in Persons Infected With Omicron BA.1 and BA.2 Sublineages and Association With Vaccination Status
Authors: Butt Adeel A. , Dargham Soha R. , Coyle Peter , Yassine Hadi M. , Al-Khal Abdullatif , Abou-Samra Abdul-Badi , Abu-Raddad Laith J.
Published: August 2022

This retrospective study compares the severity of SARS-CoV-2 infection among persons infected with BA.1 and BA.2 sublineages by vaccination status.
Association of Fatal Overdose Notification Letters With Prescription of Benzodiazepines
Authors: Kelley Marcella A. , Lev Roneet , Lucas Jonathan , Knight Tara , Stewart Emily , Menchine Michael , Doctor Jason N.
Published: August 2022

This secondary analysis of a randomized clinical trial examines the association of receipt of an injunction letter from a medical examiner following a patient’s drug overdose with patterns of benzodiazepine prescribing among physicians.