bluuebunny/crossref_metadata_2025 huggingface dataset:
Event potential of the tourist destination «DUBNO» as a tool for innovative development of the region
Authors: Mazurets Roman R. , Havrylenko Tetiana V. , Serbenivska Alina Y. , Zhuchenko Valentina G.
Published: April 2022

The article presents the substantiation that the development of the event potential of the tourist destination «Dubno» is a tool for innovative development of the region. The study used general and special scientific research methods, including structural and functional analysis, statistical method and comparative analysis. Substantiation of the research results was carried out on the basis of information sources of the State Statistics Service of Ukraine, the State Service of Tourism and Resorts of Ukraine, Dubno City Council and data from other scientific and official sources. The concept of potential potential of the tourist direction is defined, which is proposed to be a complex concept that includes a set of resources of a certain area that are used or can be used in the practice of events to attract tourists, as well as conditions that have direct or indirect impact on resource base. The main components of the event potential of the tourist direction of Dubno are analyzed and the main problems of its use are given. Natural and anthropogenic tourism and recreational-resource, natural and socio-economic conditions influencing the development of event potential of the studied tourist direction are also described. The role of the event industry in the development of tourism of the territory and its part in the increase of tourist flows as a result of the organization of tours with the use of event potential is characterized. An analysis of the development potential of the Dubno tourist destination was carried out, based on the results of which it was determined that its use will fully contribute to the growth of tourist flows, as the city has many opportunities to organize events of both local and national importance. The shortcomings that may hinder the rapid growth of the destination as a developed center of event tourism, including large-scale festival events, including insufficient accommodation and catering facilities, lack of large entertainment centers and bad-quality roads, which reduced additional investment in development of the tourist infrastructure. It is proved that the development of the event potential of a tourist destination is a tool for innovative development of the region, as it involves achieving sustainable growth of gross domestic product, industrial production and investment as a necessary basis for forming a system of necessary conditions to improve social and innovation sphere.
Assessment of risk to health of the population from soil pollution by heavy metals: theoretical- methodological and ecological aspects
Authors: Trigub Valentyna I. , Domuschy Svitlana V.
Published: April 2022

Existing methodological approaches to assessing the risk to public health from the effects of heavy metal pollution are highlighted. This article considers the influence of emissions from motor transport and industrial enterprises on the level of soil contamination by movable forms of heavy metals in different functional zones of the Odessa city. The degree of technogenic and chemical pollution of urban soils is determined by ecological indicators: concentration coefficient (Kc), hazard coefficient (Kn) and total pollution indicator (Zc). It is established that the indicators of the content of heavy metals in the humus horizons of the soils of Odessa city have a high variability and depend on the degree of industrial and transport impact. It was found that only the soils of the Botanical Garden have an optimal content of heavy metals. It is established that the soils are the most polluted by emissions from road transport in terms of lead (18 TVL), zinc (23 TVL) and cadmium (15 TVL). Accumulation of heavy metals was found in all studied soils of the city. The ecological condition of soils varies from optimal (park zone) to unsatisfactory condition (zone of joint influence of motor transport and industrial enterprises). In terms of total pollution, soils within the impact of road transport and industrial enterprises have a very high (extremely dangerous) level of pollution. The highest values of the total indicator of soil pollution were determined within the impact of road transport (Zc = 758.72) and the combined impact of industrial enterprises and road transport (Zc = 921.6). For the first time, a method was used to assess the risk to the health of the population of the Odessa city from the effects of soil contamination with heavy metals according to the probit regression model. It was determined that the study area of the city mainly has a high and dangerous risk to public health. The conducted researches allowed us to reveal the level of toxicity of the city soils and the level of danger to the health of the population, which will contribute to the implementation of appropriate measures to reduce pollution of the urban environment. The methodology for assessing the health risk from urban soil pollution by heavy metals is a promising approach to quality control of the system «environment – human health» and requires further research.
Green consumer culture as a factor of sustainable development of society
Authors: Vysotska Olha Y. , Vysotskyi Oleksandr Y.
Published: April 2022

Insufficient development of the environmental culture of society and the existing consumer culture leads to an aggravation of the ecological situation on the planet. Therefore, increasingtheawarenessandresponsibilityofthemodernconsumersocietycanbeaworthy response to this global challenge. In this regard, the process of forming a green consumer culture and greening public consciousness becomes an important object of research. In turn, this requires a conceptual analysis of the terms of environmental culture and consumer one, the features of their formation and development in society in the context of a sustainable development strategy, as well as the study of their constructive synthesis in the concept of green consumer culture. The authors define green consumer culture as a culture of behavior of an individual and society as a whole, focused on optimizing industrial and household consumer activities, taking into account environmental safety, environmentally and economically balanced value orientations based on the principles of sustainable development. Green consumer culture includes cultural and activity forms of changing the nature of consumption of natural resources, energy, food, transport, industrial and agricultural goods by individuals and society in the direction ofdeveloping environmentally balanced value orientations and behavioral patterns. In particular, this leads to a reduction of wastes. The formation of the green consumer culture of an individual by means of education for sustainable development implies a holistic approach to a human, society and nature, an understanding of the unity of modern scientific knowledge, humanistic and environmental values. The transformation of the consumer culture of an individual and society as a whole involves changing material and spiritual values, knowledge, patterns and norms of consumer behavior in the direction of spreading sustainable and environmentally balanced practices. In the context of educational tasks, this implies creation of conditions for sustainable consumer socialization as a process of developing environmentally responsible skills in order to reduce wastes, taking into account environmental requirements and socio-cultural needs of a sustainable development society. The authors prove that green consumer culture is an important factor in the sustainable development of society, as well as a basis of the modern environmental education and education for sustainable development as a more complex integrated form of obtaining knowledge and mastering the skills of environmentally balanced behavior.
Hereditary angioedema in children and adolescents
Authors: Mansour Eli , Veronez Camila L. , Craig Timothy , Grumach Anete Sevciovic
Published: April 2022

Hereditary angioedema is a genetic disease with autosomal dominant inheritance and, in most cases, caused by C1 inhibitor deficiency. Patients present with recurrent edema affecting sub-cutaneous and mucus membranes with variable onset and severity. More than 50% of patients may become symptomatic before 10 years of age. Family history can help with the diagnosis; however, approximately 25% of the cases are de novo mutations. Biochemical diagnosis should be delayed until after 1 year of age. Children were often excluded from advances in therapy for hereditary angioedema since most of the new medicines were tested in adults and thus excluded by the Food and Drug Administration (FDA) and other agencies for approval to be used in children. Treatment of attacks is available for the pediatric patient; however, barriers still exist for the use of long-term prophylaxis in young children.
Multiobjective Tree-Structured Parzen Estimator
Authors: Ozaki Yoshihiko , Tanigaki Yuki , Watanabe Shuhei , Nomura Masahiro , Onishi Masaki
Published: April 2022

Practitioners often encounter challenging real-world problems that involve a simultaneous optimization of multiple objectives in a complex search space. To address these problems, we propose a practical multiobjective Bayesian optimization algorithm. It is an extension of the widely used Tree-structured Parzen Estimator (TPE) algorithm, called Multiobjective Tree-structured Parzen Estimator (MOTPE). We demonstrate that MOTPE approximates the Pareto fronts of a variety of benchmark problems and a convolutional neural network design problem better than existing methods through the numerical results. We also investigate how the configuration of MOTPE affects the behavior and the performance of the method and the effectiveness of asynchronous parallelization of the method based on the empirical results.
Thermodynamic stability of microheterogenic states in Fe – Mn – C melts
Authors: Sinitsin N. I. , Chikova O. A.
Published: April 2022

Possibility of existence of microheterogeneous states in Fe – Mn – C melts was analyzed carried out according to the concepts of chemical thermodynamics. Microheterogeneous state of a chemically inhomogeneous Fe – Mn – C melt was understood as presence of dispersed Fe – C particles in it, which are suspended in Mn – C environment and separated from it by interface. Hypothesis of microheterogeneous state of Fe – Mn – C melts is supported by numerous experimental data on their thermodynamic and physical properties. Identification of anomalies in temperature dependences of physical properties of Fe – Mn – C melts made it possible to determine temperature values above which the melt superheating treatment (MST) leads to destruction of microheterogeneity, i.e., the liquid – liquid structure transition (LLT) in the melt. LLT is understood by authors as a structural transition “microheterogeneous melt – homogeneous solution” and this is expressed in destruction of microheterogeneous state when the melt is heated to a temperature determined for each composition (MST). This paper describes a method for theoretical determination of temperature range where microheterogeneous state of the Fe – Mn – C melt is thermodynamically stable. Thermodynamic stability of dispersed Fe – C particles in the Mn – C medium was estimated according to the equations proposed by Kaptay for a regular solution. It was assumed that interface between the melt of dispersed Fe – C particles with sizes from 2 to 34 nm, distributed in the Mn – C dispersion medium and separated from it by an interface with increased carbon content. This result of the assessment is consistent with the data on size of the structural units of a viscous flow obtained earlier within framework of the theory of absolute reaction rates.
Corrosion resistance of welded tubing of L80 strength group of different chemical composition
Authors: Kudashov D. V. , Ioffe А. V. , Naumenko V. V. , Muntin A. V. , Udod K. A. , Kovtunov S. V.
Published: April 2022

In previous publications, it was shown that the use of low-carbon steels with bainite hardenability alloyed with chromium, molybdenum and other carbonitride-forming elements is promising for the production of cold-resistant and SCC (sulfide stress corrosion cracking)-resistant electricwelded tubing (tubing). Tubing is often operated in CO2-containing corrosive environments, therefore, determining the steel resistance to this type of corrosion is an urgent task. It is known that the addition of chromium to steel increases not only its hardenability, but also its resistance to CO2 corrosion. Influence of other alloying elements is not obvious. For the laboratory experiment, nine variants of the chemical composition of steels for the production of welded tubing were developed. The rolled test steels were investigated. Results of the studies of corrosion resistance of these steels are shown and compared. The authors made an assessment of influence of the main alloying elements on resistance to CO2 corrosion. The steels with different contents of Cr, Mo, V, Mn, Zr were studied for resistance CO2 corrosion at different temperatures. It has been established that the steel chemical composition and the test conditions determine the composition of CO2 corrosion products, affect the process of formation and growth of corrosion products, thereby affecting corrosion resistance. Decrease in the corrosion rate of chromium-alloyed steels can be associated with the protective properties of the corrosion products formed during testing. Laboratory corrosion tests for resistance to CO2 corrosion at an elevated temperature of 65 °C and subsequent studies of the formed corrosion products revealed a positive effect of chromium and molybdenum on the rate of general corrosion by mechanism of formation of dense corrosion products that perform a protective function.
Development and research of a multistage hydraulic gear-multiplier drive for metallurgical presses
Authors: Pilipenko S. S. , Potapenkov А. P. , Vakulenko A. I. , Yanko Ya. Yu.
Published: April 2022

The paper presents one of the solutions to reduce the installed power and increase efficiency of hydraulic pump drive of high power pressing equipment used in metallurgical plants. The authors have developed a multistage hydraulic drive based on a block gear-multiplier. Plungers of all cylinders form a movable block, the cylinders – a stationary one. The mode of operation (reduction, multiplication) is provided by a combination of output cylinders supplying fluid to the power cylinder by switching some of them to drain. Analysis of a four-stage drive with a three-stage multiplier gearbox is presented in comparison with a simple pump drive. A four-stage drive with two output cylinders provides a reduction gear and two multiplier stages, with which a stage of fluid supply to the power cylinder directly from the pumps (pump stage) is combined. Power and kinematic parameters of the drive were determined by the power loading during the working stroke and speed mode during the working cycle (forward (idle and working stroke) and reverse stroke). It is advisable to use a multi-stage drive with a smoothly increasing load over the entire length of the working stroke (upsetting, drawing operations). Analysis of the basic and additional combination of stages for linearly increasing power load, which was determined by the pressure at the beginning of Р0 , and the maximum pressure at the end of the working stroke Рmax was carried out. In the basic version, a gear stage (idle stroke), pump stage and two multiplier stages (working stroke) are sequentially combined. With an additional combination, the reduction stage covers idle stroke and initial part of the working stroke. Analysis was carried out under the condition of equality of pressure and power of the pumps in stages and the condition of equality of direct stroke time of the compared drives. The ratio of pump capacities was estimated. Dependences of the main parameters of the developed drive, reduction and multiplication factors were obtained. With the accepted initial data, it is possible to reduce the pressure and power of the developed drive pumps (in comparison with the simple one) by 28 – 37 % with an additional combination of stages (increases with an increase of an idle stroke). It is lower for the basic combination by 5 – 9 % (reduction is greater at lower idle stroke values). The use of an additional combination is limited by the ratio P0/Pmax ≤ 0/4.
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Authors: not provided spartanmes
Published: April 2022

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Authors: Prime Diet Keto
Published: April 2022

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Authors: not provided susangranj
Published: April 2022

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Authors: CBD Gummies Oros
Published: April 2022

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Authors: Prime Diet Keto
Published: April 2022

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Investigation of the influence of hydraulic oil temperature on the variable-speed pump performance
Authors: Stawiński Łukasz , Kosucki Andrzej , Cebulak Maciej , Górniak vel Górski Adrian , Grala Mikołaj
Published: April 2022

This paper describes investigation on the influence of hydraulic oil temperature on the performance of a hydraulic pump. The aim of the research is to determine changes in volumetric efficiency of the pump in the form of maps of operation at different temperatures of the hydraulic oil, in conditions of variable speed and pressure. The described tests were carried out on an experimental stand with a hydraulic fixed-displacement gear pump controlled by a servo motor. Based on the signals from the sensors processed with the LabVIEW program, maps of the hydraulic pump operation were drown in a wide range of speeds and temperatures. The paper presents the results of the research and based on this the conclusions regarding the main aim of the research and others that were observed during the measurements were presented. The most important conclusion from the study shows that the temperature-dependent characteristics provide users with a significant amount of information such as operating conditions that will ensure a high level of efficiency.
Estudar onde é bom viver? Bem-estar subjetivo e qualidade de vida no ensino superior: o caso de estudantes brasileiros no Algarve
Authors: Ferreira Lara Noronha , Pereira Luis N. , Brás Maria da Fé
Published: April 2022

Este trabalho analisou os níveis de bem-estar subjetivo (BES) e de qualidade de vida (QV) nos estudantes brasileiros que estudam na Universidade do Algarve (UAlg) a partir da constatação do significativo aumento destes em universidades portuguesas. Foi realizado um inquérito por questionário com entrevista eletrónica, constituído pela Escala de Bem-Estar Subjetivo e pelo WHOQOL-Bref, tendo participado 102 estudantes. Os resultados mostraram que os estudantes brasileiros que consideram a UAlg um bom sítio para estudar e um bom local para viver apresentam níveis mais elevados de QV e de BES. Aqueles que não tiveram crises emocionais e os que estão bem integrados têm uma QV e um BES mais elevado. Os estudantes com um nível físico e de relações sociais mais elevados têm maior probabilidade de considerarem a UAlg uma boa universidade para estudar. Conclui-se que os estudantes brasileiros têm um bom nível de BES e de QV.
HIV Stigma Scale: Translation and Validation of the Short Version to the Portuguese Population
Authors: Gonçalves Mariana , Morgado Diogo , Castro Bárbara , Maia Ângela
Published: April 2022

The objective was to translate, adapt, and analyze the psychometric properties of a shortened version of the HIV Stigma Scale using a sample of 100 HIV+ adults, with a mean age of 49.88 (SD = 12.03) diagnosed for an average of 9.39 (SD = 7.36) years. The psychometric properties of the short version of the Stigma Scale were analyzed through the one-factor structure and the original four-factor structure, showing good fit for this last model. Convergent validity was found to be close to the acceptable for the factors, “concerns about public attitudes” and “negative self-image”, and good for the factors, “disclosure concerns”  and “personalized stigma”. The results showed adequate discriminant validity for all factors, coefficient Omega was above .70  for the four factors, showing adequate reliability. This Portuguese version of the Stigma Scale is a good measure to assess the stigma of people living with HIV.
Estado emocional e coping em estudantes universitários no confinamento provocado pela COVID-19
Authors: Alexandre Joana Dias , Carvalho Helena , Fonseca Ana Margarida , Castro Catarina Alexandra
Published: April 2022

Considerando a vulnerabilidade da saúde mental dos jovens adultos, e a mudança abrupta das suas rotinas no primeiro confinamento decretado em Portugal, em março de 2020, devido à pandemia provocada pela COVID-19, este estudo analisou 1) o estado emocional de uma amostra de estudantes universitários durante o primeiro confinamento, 2) as estratégias de coping reportadas durante esse período, 3) o papel mediador das estratégias de coping no reporte de sintomas de ansiedade, depressão e stress. Os resultados indicam que, à semelhança de outros países, as mulheres reportam maiores níveis de ansiedade, depressão e stress. Também são estas que reportam não só o recurso a estratégias de coping negativo, mas também positivo (suporte social). O retraimento e a recusa medeiam a relação entre o sexo do participante e o estado emocional. Os resultados apontam para um conjunto de reflexões sobre intervenções de promoção de bem-estar em jovens universitários.
SECONDARY HYPERTENSION: GENES THAT STIMULATE EXCESSIVE SECRETION OF ALDOSTERONE
Authors: SYED MOHAMMED NAZRI SITI KHADIJAH  & ELENA AISHA AZIZAN , AZIZAN ELENA AISHA
Published: April 2022

Hypertension is highly prevalent in Malaysia and even the rest of the world. Primary aldosteronism (PA) is one of the most common treatable cause of secondary hypertension. PA occurs due to excessive secretion of aldosterone in the adrenal glands. Up to one in five resistant hypertension cases are due to PA. Therefore, there are a high number of individuals who have the potential to be cured of their hypertension. However, this is difficult to achieve due to limitations in the procedure of diagnosing the PA disease. The challenge now is to know the best usage of available diagnostic methods to detect those who would most likely be cured of hypertension which may be associated with the genotype of the disease. In the past decade, five genes have been found to cause excess aldosterone production in aldosteroneproducing adenomas (APAs), namely KCNJ5, ATP1A1, ATP2B3, CACNA1D and CTNNB1. These somatic mutations have been found to activate the intracellular signaling pathway that regulates aldosterone production. Studies on bilateral adrenal hyperplasia (BAH) samples also have identified the genetic causes for the many hereditary hyperaldosteronism, namely familial hyperaldosteronism types I, II, III, and IV/V. Herein we review the genetic factors of PA as a result of either aldosterone-stimulating somatic mutations or germline variants, and the associated clinical phenotype. Keywords: Primary aldosteronism; hypertension; hyperaldosteronism; mutation
EFFECTS OF MUSIC THERAPY ON PSYCHOLOGICAL DISTRESS OF NEUROSURGICAL PATIENTS: A SYSTEMATIC REVIEW
Authors: DEVARAJ DIVAASINI , AHMAD MAHADIR
Published: April 2022

Neurosurgery has been on the rise, with a yearly estimate of 13.8 million patients suffering from neurological disorders or injuries and require surgery. Psychological distress is relatively frequent in neurosurgical patients due numerous threats and challenges faced therefore, the main objective of this review is to understand the efficiency of music therapy on neurosurgical patients in reducing psychological distress. The Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) framework was used to guide the methodology of this systematic review. The PICO format was used as a search strategy in terms of specifying search terms and clarifying limits in relation to the population or intervention studied in this review. Databases like SCOPUS, MEDLINE and OVID, The Cochrane Library was utilized to search for relevant records. A total of 48 studies were identified through the databases search. After the removal of duplicates, 39 studies’ titles and abstracts were screened. Through a process of assessing eligibility, 5 studies were consequently included in the review. The year limits for the articles reviewed were 2015 to present, to highlight the more recent findings on the subject. The studies included in this review encompass different countries of origin such as USA, Canada and in Asia, Taiwan, China and India. The findings of this review show that music therapy is an effective intervention in reducing psychological distress, especially anxiety, in neurosurgical patients. Music therapy is also effective as an adjunct therapy for neurosurgical procedures. The cultural aspects infused in music therapy were also discussed in this paper
Autoimmune Haemolytic Anaemia: A cross sectional study in a Tertiary Haematological Centre
Authors: SULAIMAN WAHINUDDIN , BALWANT SINGH JASRAM SINGH SIDHU , SHAMZUL HISHAM NUR ADLIN SYAFIKA , MARHASSAN NURUL SYAZWANI ZAKIAH , ANUAR SITI AISHAH , KIRUBAMOORTHY KAMINI
Published: April 2022

Autoimmune haemolytic anaemia (AIHA) is a group of disorders wherein autoantibody causes decompensated acquired haemolysis. There has been no epidemiological study of autoimmune haemolytic anaemia (AIHA) in Malaysia. This study retrospectively analysed the epidemiology of AIHA including Evan’s Syndrome in a Tertiary Haematology Centre in Malaysia. Patients diagnosed with AIHA and Evan’s Syndrome at 18 years old and above between 1 January 1994 to 1 October 2020 at the out-patient Haematology Clinic of Hospital Raja Permaisuri Bainun, Ipoh were selected. Patients’ information was retrieved from the outpatient clinic records. A total of 71 patients were included of which predominantly female. The mean age for both genders were comparable. Ethnic stratification revealed AIHA was higher in Malays followed by Chinese and Indian. Warm AIHA was most prevalent at 40.8%, compared to cold AIHA and Evan’s Syndrome (both 23.9%), and mixed AIHA (11.3%). Primary was more common than secondary AIHA followed by Evan’s Syndrome. Approximately half of the secondary AIHA and secondary Evan’s Syndrome were due to SLE. Overall, 67.6% of patients received corticosteroid only and 28.2% combined with immunosuppressant. Individuals at higher age and females have higher risk of developing AIHA and Evan’s Syndrome. The highest prevalence was seen among the Malay ethnic. Primary warm AIHA is the most common type and majority of Evan’s syndrome are secondary to autoimmune diseases.
Challenges, Attitudes and Skills of Occupational Therapists towards Pre-Driving Assessments Practices in Malaysia
Authors: YUAN HUI LAU , MOHD RASDI HANIF FARHAN , HARUN DZALANI , XUN YUN CHANG
Published: April 2022

A pre-driving assessment usually involves standardised and non-standardised tests to examine the skills for safe driving of people with disabilities. However, it is still unknown to what extent the pre-driving assessments are being practised among occupational therapists in Malaysia. Therefore, this study aims to investigate the association of challenges, attitudes, and skills of occupational therapists towards practising driving rehabilitation and explore the most used predriving assessment. A cross-sectional study had been conducted from July to September 2020. The convenient sampling method was used to recruit experienced occupational therapists in driving rehabilitation. A total of 53 therapists had completed an online survey. According to the results, the bivariate correlation between skills and challenges was positive and strong (rѕ = 0.680, p < 0.05). A multivariate analysis of variance (MANOVA) indicated that workplace variables had a significant effect on the combined dependent variables of challenges, attitudes, and skills, F(3,49) = 4.521 p = 0.007, partial Ƞ² = 0.217. This study found that the most used standardised assessment was the range of motion (n = 39, 73.6 %) and the right and left discrimination (n = 40, 75.5 %). The findings of this study identified that occupational therapists challenges and attitudes are significantly associated with the skills to practice driving rehabilitation. Malaysian occupational therapists working in the government sector reported better skills than those working in the private sector. Furthermore, numerous types of pre-driving assessments were used and vary from setting to setting. This study hopes to benefit occupational therapists and related rehabilitation practitioners towards a holistic understanding of Malaysia's driving rehabilitation practices.
Increased oxidative stress in adult women with iron deficiency anemia
Authors: KARABULUT Alpaslan , ALP AVCI Gulcin , AVCI Emre
Published: April 2022

BackgroundIron deficiency anemia (IDA), a type of anemia with an increasing global frequency, is more common in women than men in the population. In IDA, the sensitivity of erythrocytes to oxidants is increased and their lifespan is shortened. Oxidative stress is an imbalance between free radicals and antioxidant molecules which is one of the potential biochemical mechanisms involved in the pathogenesis of IDA. In our study, we aimed to determine the levels of oxidant and antioxidant markers by assessing the levels of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase-1 (PON-1), and myeloperoxidase (MPO) in women with IDA.
MethodsThis was a cross-sectional study involving 47 women with IDA aged ³40 years and 47 women volunteers. The levels of TAS, TOS, OSI, PON-1, and MPO were determined spectrophotometrically using appropriate kits. Non-parametric Mann Whitney-U tests were used to analyze the data.
ResultsThe levels of antioxidants TAS (1.42 mmol Trolox equiv./L) and MPO (54.00 U/L) in the IDA group were significantly lower than in the control group [TAS (1.67 mmol Trolox equiv./L) and MPO (89.00 U/L)] (p=0.000 and p= 0.019, respectively). However, TOS (6.25 ìmol H2O2 equiv./L) level in the IDA group was significantly higher than in the control group (4.13 ìmol H2O2 equiv./L) (p=0.000), but PON-1 was not significantly different between the two groups (p=0.375).
ConclusionIn women with IDA, the oxidant-antioxidant balance is impaired, resulting in oxidative stress. Therefore, IDA in adult women must receive adequate attention in clinical practice.
Death anxiety and its association with severity of mental illness in patients with depression and schizophrenia
Authors: Shahraki Mojahed Hamidreza , Nakhaei Somayeh
Published: April 2022

BackgroundDeath and the anxiety of it becomes more apparent when confronted with a chronic disease. The aim of this study was to determine the level of death anxiety among patients with depression and schizophrenia, and the relationship between severity of the symptoms and death anxiety in these patients.
MethodsA cross-sectional study was conducted on 29 patients with a depressive disorder, 18 with schizophrenia spectrum disorder and 31 healthy subjects, through face-to-face interviews. The general severity of the psychiatric disorder was measured using the Clinical Global Impression Scale (CGI). The severity of depressive symptoms was measured using the Beck Depression Inventory (BDI). Psychosocial performance was measured using the personal and social performance scale (PSP). To evaluate death anxiety, the Bochum Questionnaire on attitude to death and death anxiety 2.0 (BOFRETTA 2.0) was used. One-way ANOVA and Pearson correlation tests were used to analyze the data.
ResultsRegarding the BOFRETTA attitude scale, the schizophrenic patients (23.1±9.12) showed significantly higher scores than healthy subjects (18.4 ±4.56) and depressive patients (19.8 ± 5.20) (p<0.050). The healthy controls achieved the least scores of BOFRETTA anxiety scale followed by depressive (30.67±10.33) and schizophrenic patients (31.30±12.18). However, there were no significant between-group differences regarding this scale. We found significant correlations of all BOFRETTA dimensions (attitude, anxiety, sum score) with CGI, PSP and BDI.
ConclusionThere was a significant relationship between the severity of symptoms and death anxiety in both depressed and schizophrenic patients. However, the latter showed a more negative attitude towards death.
Microscopic examination using negative staining for rapid diagnosis of syphilis
Authors: Rosana Yeva , Effendi Ida , Indriatmi Wresti , Yasmon Andi
Published: April 2022

BACKGROUNDSyphilis is a global health problem, especially in developing countries including Indonesia. Treponema pallidum, the etiologic agent of syphilis, cannot be cultured in vitro. Syphilis has several clinical manifestations, making laboratory testing a very important aspect of diagnosis. Microscopic examination may support the diagnosis but is rarely used in Indonesia. The aim of this study was to evaluate negative staining using the light microscope to detect T. pallidum in syphilitic lesions.
METHODSA cross-sectional study was conducted involving 27 subjects who came to several dermato-venereology clinics in Jakarta. Exudates were collected from genital ulcers, condylomata lata, and dry mucocutaneous rash on palms and soles of syphilis patients. Negative staining using one drop of Indian ink was used to examine for treponemas under the light microscope at 10x100 magnification.
RESULTSMicroscopic examination using negative staining showed a few clusters of small and spiral shaped bacteria. Of the 39 specimens from 27 subjects, microscopic examinations were successfully done on 10 specimens. Observations could only be conducted on 5 specimens, 3 (60.0%) of which showed the morphology of spirochetes. This examination is the easiest method for detecting the bacteria. Moreover, the bacteria that were isolated from painless genital ulcers could be observed more clearly than those from erythematous maculopapular lesions.
CONCLUSIONTreponema pallidum was successfully detected by microscopic examination in all moist lesions, but was difficult to detect in dry lesions. Negative staining under the light microscope appears to be simple, affordable, and available in most microbiology laboratories in Indonesia.
Barriers to breast cancer screening in Iranian females: a review article
Authors: Masoudi Nazanin , Dastgiri Saeed , Sanaat Zohreh , Abbasi Zhila , Dolatkhah Roya
Published: April 2022

Breast cancer is one of the most common malignancies among females in Iran. Screening and detection in the early stages can increase the likelihood of breast cancer treatment and prognosis, thereby decreasing the mortality rate and promoting patient survival. However, mass screening programs for breast cancer are still confronted by predominant barriers in Iran. We tried to review and recognize the barriers to breast cancer screening and early detection in Iranian females as the main research question. We searched all available databases, and screened manuscripts for eligibility according to our inclusion/exclusion criteria. The search strategy was based on the following keywords: Breast, Malignancy, Cancer, Screening, Early Detection, Mammography, Iran, and Barrier. Responsible authors performed a literature review and compiled the results into a report. Various perceived barriers at different levels (individual, intrapersonal, health systems, and community) play influential and pivotal roles in women’s decisions to participate in breast cancer screening programs to facilitate early detection. Lack of awareness, neglect, procrastination, embarrassment, religious beliefs, and lack of primary health workers awareness and recommendation were cited as perceived barriers in screening procedures in Iran. There are still barriers in performing mammography at population levels in five major dimensions including availability, accessibility, cost, fears, and acceptability. However, the rate of regular mammography utilization in Iran is low compared with other countries and needs increasing through informing women. Many perceived barriers can affect women’s willingness and self-efficacy in screening procedures and one of the most effective ways of overcoming these barriers is to increase women’s awareness.
Method stability indicating method development and validation for emtricitabina by UV spectroscopic and RP-HPLC methods
Authors: Shelke Ashwini , Surwae Pooja , Bendale Atul R , Borse Laxmikany , Jadhav Anil G
Published: April 2022

Emtricitabine (commonly called FTC, systematic name 2 & 3’-dideoxy-5-fluoro-3-thiacytidine) is a nucleoside reverse-transcriptase inhibitor (NRTI) for the prevention and treatment of HIV infection in adults and children. The UV analysis of the drug was carried out on the 240nm wavelength. A simple, sensitive and accurate RP-HPLC method has been developed& validated for the determination of Emtricitabine in bulk formulation. Present method shows high sensitivity with linearity 10 to 50µg/ml (r2 = 0.9991). Various parameters according to ICH guidelines are followed for validating and testing of this method. Detection limit and quantitation limit were found to be 0.1534 µg ml and 0.4649 µgml respectively. The results demonstrated that the procedure is accurate, specific and reproducible and also being simple, cheap and less time consuming and appropriate for the determination of Emtricitabine in bulk formulation.
Design of chemical synthesis of trioxan derivatives in respect of artemisinin as anti malarial drug
Authors: Girendra Kumar Gautam
Published: April 2022

Trioxane is a six membered heterocyclic ring system with Carbon, Hydrogen and Oxygen where the oxygen is hetero atoms. Trioxane has total three oxygen atom in its ring. It can be the alternate of Artemisinin that shows anti malarial activity. Substituting trioxane can be prepared by various substitutions perhaps in the minimum requirement to show biological activities similar to Artemisinin. Artemisinin is a Chinese herb that has been used in the treatment of fevers for over 1,000 years. The chemical composision of Artemisinin is known and structurally it also has heterocyclic ring comprising the oxygen. So, Author proposed the findings of possibility of synthesis of trioxane in respect of Artemisinin as trioxane derivatives through different complex pathways. This paper focus on different strategies followed for the convenient synthesis of trioxane derivatives.
Development and validation of stability-indicating RP-HPLC method for the estimation of azoxystrobin in its formulations
Authors: Venkatasubba Naidu N. , Rahul G. , Ramachandra B.
Published: April 2022

The current work established and validated a simple, selective, precise, and accurate HighPerformance Liquid Chromatographic technique (HPLC) for the analysis of Azoxystrobin in its formulations. The mobile phase is made up of a combination of mobile phases comprising Acetonitrile and water in proportion, 80:20 (v/v). At a run duration of 15 minutes, this was found to yield a sharp peak of Azoxystrobin. Azoxystrobin was analysed using HPLC at a wavelength of 255 nm at a flow rate of 1.0 mL/min. The calibration curve's linear regression analysis results revealed a satisfactory linear connection with a regression coefficient of 0.999 in the concentration range of 50% to 150 %. The linear regression equation was y = 2025x +123.2.The proposed approach was used to analyse Azoxystrobin with a high degree of precision and accuracy.The method was validated for precision, accuracy, specificity, ruggedness and robustness. This method is useful for the quantification of Azoxystrobin because of its precision, accuracy, short retention duration, sensitivity, and mobile phase composition.
Extraction and characterization of antimicrobial pigment from marine bacteria and testing of antimicrobial activity against penicillin resistant
Authors: Soundhari C. , Haripriya K. B.
Published: April 2022

The current study shows the extraction of pigment from pigment producing bacteria isolated from marine sediment. The isolation of pigment producing bacteria was done by spread plate method. The marine nutrient medium was used for the isolation procedure. Further, subculture was followed to get desired pure culture. From the isolated culture, various preliminary test, biochemical test, molecular characterization and antimicrobial activity were performed. To extract the pigment a solvent centrifugation process was carried out. The extracted pigment was tested against drug resistant Staphylococcus aureus. Based on the FTIR spectrum respective functional group were identified from extracted pigment. After GC-MS spectral analysis specific Neoisolangifolene (32.73%) compound was identified from the total pigment extract. UV-Visible spectral studies of the pigment extract have confirmed with the variations in absorption peak of total pigments. The isolated organisms were identified based on 16s rRNA partial gene sequence analysis identified as Micrococcus flavus.
Design, synthesis and anticancer activity studies of some novel 1,2,4 triazole pyridine derivatives
Authors: Chakraborty Anup K , Patel Namrata , Karole Sarita , Loksh Kavita R.
Published: April 2022

The development of new anticancer agents is one of the most pressing research areas in medicinal chemistry and medicine. The importance of triazole and pyridine rings as scaffolds present in a wide range of therapeutic agents has been well reported and has driven the synthesis of a large number of novel anticancer agents. The presence of these heterocyclic furnishes extensive synthetic possibilities due to the presence of several reaction sites. Prompted by these data we designed, synthesized and evaluated a series of novel 1, 2, 4-triazole-pyridine hybrid derivatives as potential anticancer agents.

To design and synthesize series of novel 1, 2, 4-triazole-pyridine hybrid derivatives as potential anticancer agents

Derivatives were synthesized by the reaction of nicotinohydrazide with carbon disulfide to yield potassium-3-pyridyl-dithiocarbazate (I). This was further cyclized with ammonia solution to yield 5-mercapto-substituted 1, 2, 4-triazole-pyridine hybrid (II). This was finally reacted with different substituted benzyl derivatives to produce 1, 2, 4-triazole-pyridine hybrid derivatives (III). The purity of the derivatives was confirmed by thin-layer chromatography and melting point. Structure of these derivatives was set up by determining its infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectroscopy. Further, the synthesized 1, 2, 4 triazole pyridine derivatives were tested for their in vitro anticancer activities against murine melanoma (B16F10) using the MTT reduction assay method.

The cell viability study of synthesized compounds concludes that all compounds have moderate to potent anticancer activities against cancer cell lines. Compounds TP1-TP7 have IC in the range of 41.12μM to 61.11μM and the highest activity was observed for compound TP6 against murine melanoma (B16F10) cell line.

Thepresent research may pave a way for the development of 1, 2, 4-triazole-pyridine as novel anticancer agents with good efficacy and lesser adverse effects.
Tendências das Propostas de Gamificação no Moodle: uma Revisão Sistemática
Authors: Porto Bruno , Battestin Vanessa
Published: April 2022

A gamificação é uma abordagem que utiliza elementos de jogos e a sua exploração vem despertando o interesse de pesquisadores, professores e alunos em promover um processo de ensino-aprendizagem mais engajador, inclusive em ambientes virtuais de aprendizagem (AVAs). Diante disso, este trabalho apresenta os resultados da Revisão Sistemática da Literatura (SLR), que analisou 22 artigos, selecionados nas bases da Abed, Google Scholar, IEEExplore e SBC. Os resultados mostraram que os pontos, rankings e emblemas são os elementos mais utilizados no ambiente virtual de aprendizagem Moodle, e entre os aspectos potenciais no processo de ensino-aprendizagem, destacam-se a motivação e o engajamento dos alunos.

Palavras-chave: Gamificação. Moodle. Motivação.
Digital Intellectual Dynamics: A Perspective on Performance at a Brazilian E-Commerce Firm
Authors: PIGOLA Angelica , COSTA Priscila Rezende da DA
Published: April 2022

Using the intellectual capital and dynamic capability literature as known dimensions of organizational performance in digital contexts, this article develops a new testable model that attempts to explain digital intellectual dynamics’ (DID) impact on a Brazilian e-commerce firm’s performance. Using a quantitative methodological approach, an inedited instrument of research is used to gather data from 77 managers, and, through exploratory factor analysis (EFA), a replicability analysis (generalized H (G-H) index) is conducted along with quality and effectiveness assessment through factor score validation in Factor 10 software. Structure Equation Modelling (SEM) is used to test the hypotheses. The results reveal that DID, as a second-order variable, and Digital Human Dynamics and Digital Social Dynamics, as first-order variables, are positively related to firm performance. Digital Structure Dynamics, another first-order variable, has a positive effect on firm performance but not at a statistically significant level. This empirical result brings visibility to the role of DID in firms’ performance, creating a strategic perspective for a firm’s management in digital contexts. Furthermore, digital information systems (DIS) researchers may view these results as a response to digital disruption and a reinvention of core functions in a new strategic approach to support e-commerce transactions and firm performance. On a methodological level, the use of EFA introduces new indexes to measure this innovative instrument, as it is the first time it is used in social science research. Practitioners may use these results to enhance their firm’s performance through DID.
Review of the Factors Affecting Dichotic Listening
Authors: Majidpour Amir , Moheb Aleaba Mahshid , Aghamolaei Maryam , Nazeri Ahmadreza
Published: April 2022

Background and Aim: Dichotic listening (DL) test is a  non-invasive  method  used  to study hemispheric asymmetry, hemispheric dominance for language processing, or brain lateralization. In addition to the type, concurrence, and the intensity of stimuli presented to the ears, other factors exist that may have less effect on the DL test results. This review study aims to find these factors.
Recent Findings: The factors that affects the DL included ear advantage, attention, working memory, gender, and top-down and bottom-up factors. These factors were reviewed and discussed in detail so that more precise test results can be obtained. Moreover, due to the significant effects of each factor on the test results, manipulation of these factors was also reviewed.
Conclusion: According to the results of previous studies, ear advantage, attention, working memory, gender, and top-down and bottom-up factors play an important role in the interpretation of DL results; their negligence during the test can affect the outcomes and provide incorrect brain lateralization results.
Keywords: Dichotic listening; ear advantage; top-down; bottom-up; working memory; attention