bluuebunny/crossref_metadata_2025 huggingface dataset:
Trends in the abundance of Celtic Sea demersal fish: Identifying the relative importance of fishing and environmental drivers
Authors: Kempf Jed , Breen Patricia , Rogan Emer , Reid David G.
Published: September 2022

The Celtic Sea is a productive fishing ground, therefore identifying the relative importance of fishing and environmental factors on fish stock dynamics is crucial for developing our understanding of sustainable yields and to operationalize Ecosystem Based Fisheries Management (EBFM). We investigated the effect of environmental variables and fishing on the relative abundance inferred from catch-per-unit-effort (CPUE), of twelve demersal stocks (i.e., cod, haddock, whiting, anglerfish, hake, megrim, plaice, sole, lesser-spotted dogfish, spurdog, Trisopterus spp., skates and rays) in the Celtic Sea from 1997 to 2019 (23 years). Annualized time series (1997-2019) of net primary production, bottom temperature, copepod abundance (Calanus finmarchicus and Calanus helgolandicus) and North Atlantic Oscillation index were used to characterize key environmental variables. Fishing exploitation rates (F/FMSY) were used to represent fishing pressure and CPUE trends derived from an International Bottom Trawl Survey (IBTS) were used to infer abundance. We used redundancy analysis to identify key explanatory variables and then dynamic factor analysis to assess their relationships with the CPUE series and identify underlying patterns in the unexplained temporal variation. Our results show that for the majority of demersal fish species, the CPUE trends were strongly influenced by fishing exploitation rates. The gradual reduction in exploitation rates observed throughout the study period most likely led to the partial recovery of cod, spurdog, hake, megrim, plaice, whiting, Trisopterus spp., and the skates and rays. In addition, exploitation patterns on one stock influenced CPUE trends of other demersal stocks (e.g., hake, megrim, plaice, lesser-spotted dogfish, sole). We also observed that the CPUE of whiting, hake and plaice increased when C. finmarchicus were abundant in the plankton. We infer from our findings in the investigated time series that the recovery of cod, spurdog, hake, megrim, plaice, whiting, Trisopterus spp., and the skates and rays in the Celtic Sea remains dependent on controlling fishing mortality, and this would not, at least for now, be confounded by the environmental conditions.
Seasonal energetic physiology in the ark shell Anadara kagoshimensis in response to rising temperature
Authors: Kang Hee Yoon , Seong Jaeeun , Kim Changseong , Lee Byeong Gweon , Lee In Tae , Kang Chang-Keun
Published: September 2022

Knowledge of physiological responses of important shellfish species to rising temperatures is crucial in assessing the impacts of climate change on marine aquaculture production. The physiological components of energy balance that support growth performance were measured seasonally at different exposure temperatures in the ark clams (Anadara kagoshimensis) cultured in the shallow muddy bottom sediment in Yeoja Bay, Korea. We tested the effects of winter minimum (3–8°C) and summer maximum (23–28°C) temperature elevations on individual physiological processes (ingestion, respiration, egestion, and excretion) and the combined energetic physiology (scope for growth [SFG] and net growth efficiency [K2] measures). The seasonal cycle of dry flesh tissue weight (DW) was also investigated from January 2016 to November 2018, to compare its variation at contrasting cold vs. warm regimes. The rates of physiological components were related to DW, generating significant allometric equations. The weight exponents of the equations for ingestion rate and respiration rate were low at the winter minimum compared with the remaining season temperatures, indicating a higher thermal sensitivity in larger individuals. The physiological rates that were re-calculated for individual components based on estimates of the slope and intercept of the equations increased with increasing temperature, revealing an incapability of thermal acclimation and a temperature effect at seasonally different endogenous conditions. The thermal sensitivity (Q10) of the ingestion rate and respiration rate was reversed between the winter minimum and the summer maximum temperature elevations, yielding negative SFG and K2 values at 3 and 28°C. Furthermore, the interannual difference in the seasonal cycle of clam DW displayed variations in the period of increment prior to spawning and the post-spawning loss/recovery in association with its energy balance status in the winter and summer temperature conditions. Overall, these results indicate that warming is projected to affect physiological performance and the seasonal DW cycle of clams in different manners between winter and summer: physiological benefits and advanced weight gain vs. heat stress and progressive weight loss, respectively. The mechanistic adjustment of the clam energy balance across thermal conditions seems to explain the recent advancement in its seasonal biological cycle, as well as the failure in spat collection and the mass summer mortality observed at this culturing site.
Sea ice recognition for CFOSAT SWIM at multiple small incidence angles in the Arctic
Authors: Liu Meijie , Yan Ran , Zhang Xi , Xu Ying , Chen Ping , Zhao Yongsen , Guo Yuexiang , Chen Yangeng , Zhang Xiaohan , Li Shengxu
Published: September 2022

Sea ice recognition is one of the main tasks for sea ice monitoring in the Arctic and is also applied for the detection of other ocean phenomena. The Surface Wave Investigation and Monitoring (SWIM) instrument, as an innovative remote sensor that operates at multiple small incidence angles, is different from existing sensors with moderate and normal incidence modes for sea ice monitoring. Sea ice recognition at small incidence angles has rarely been studied. Moreover, SWIM uses a discrimination flag of sea ice and sea water to remove sea ice from sea wave products. Therefore, this research focuses on sea ice recognition in the Arctic based on SWIM data from October 2020 to April 2021. Eleven features are first extracted, and applied for the analysis of the waveform characteristics using the cumulative probability distribution (CPD) and mutual information measurement (MIM). Then, random forest (RF), k-nearest neighbor (KNN) and support vector machine (SVM) classifiers are built, and their abilities of sea ice recognition are assessed. The optimal classifier is the KNN method with Euclidean distance and k equal to 11. Feature combinations are also used to separate sea ice and sea water based on the KNN method to select the optimal combination. Thus, the optimal classifier-feature assembly at each small incidence angle is established, and the highest overall accuracy reaches 97.1%. Moreover, the application of the optimal classifier–feature assemblies is studied, and its performance is fairly good. These assemblies yield high accuracies in the short- and long-term periods of sea ice recognition, and the overall accuracies are greater than 93.1%. So, the proposed method satisfies the SWIM requirement of removing the sea ice effect. Moreover, sea ice extents and edges can be extracted from SWIM sea ice recognition results at a high level of precision greater than 94.8%. As a result, the optimal classifier–feature assemblies based on SWIM data express the effectiveness of the SWIM approach in sea ice recognition. Our work not only highlights the new sea ice monitoring technology of remote sensing at small incidence angles, but also studies the application of SWIM data in sea ice services.
XBT operational best practices for quality assurance
Authors: Parks Justine , Bringas Francis , Cowley Rebecca , Hanstein Craig , Krummel Lisa , Sprintall Janet , Cheng Lijing , Cirano Mauro , Cruz Samantha , Goes Marlos , Kizu Shoichi , Reseghetti Franco
Published: September 2022

Since the 1970s, eXpendable BathyThermographs (XBTs) have provided the simplest and most cost-efficient solution for rapid sampling of temperature vs. depth profiles of the upper part of the ocean along ship transects. This manual, compiled by the Ship of Opportunity Program Implementation Panel (SOOPIP) a subgroup of the Global Ocean Observing System (GOOS) Observations Coordination Group (OCG) Ship Observations Team (SOT) together with members of the XBT Science Team, aims to improve the quality assurance of XBT data by establishing best practices for field measurements and promoting their adoption by the global operational and scientific community. The measurement system components include commercially available expendable temperature probes, the launcher, the data acquisition (DAQ) hardware, a Global Navigation Satellite System (GNSS) receiver, an optional satellite transmitter, and a computer with software controls. The measurement platform can be any sea-going vessel with available space for the equipment and operator, and capable of oceanic voyages across the regions of interest. Adoption of a standard methodology in the installation and deployment of the measurement system will lead to data quality improvements with subsequent impact on the computation and understanding of changes in the near surface ocean properties (e.g., heat content), ocean circulation dynamics, and their relationship to climate variability.
Activation of the Nrf2/ARE signaling pathway protects against palmitic acid-induced renal tubular epithelial cell injury by ameliorating mitochondrial reactive oxygen species-mediated mitochondrial dysfunction
Authors: Jiang Xu-shun , Cai Meng-yao , Li Xun-jia , Zhong Qing , Li Man-li , Xia Yun-feng , Shen Qing , Du Xiao-gang , Gan Hua
Published: September 2022

Chronic kidney disease (CKD) is often accompanied by dyslipidemia, and abnormal lipid metabolism in proximal tubule cells is considered closely related to the dysfunction of proximal tubule cells and eventually leads to accelerated kidney damage. Nuclear factor E2-related factor 2 (Nrf2), known as a redox-sensitive transcription factor, is responsible for regulating cellular redox homeostasis. However, the exact role of Nrf2 in dyslipidemia-induced dysfunction of proximal tubule cells is still not fully elucidated. In the present study, we showed that palmitic acid (PA) induced mitochondrial damage, excessive mitochondrial reactive oxygen species (ROS) (mtROS) generation, and cell injury in HK-2 cells. We further found that mtROS generation was involved in PA-induced mitochondrial dysfunction, cytoskeletal damage, and cell apoptosis in HK-2 cells. In addition, we demonstrated that the Nrf2/ARE signaling pathway was activated in PA-induced HK-2 cells and that silencing Nrf2 dramatically aggravated PA-induced mtROS production, mitochondrial damage, cytoskeletal damage and cell apoptosis in HK-2 cells. However, the mitochondrial antioxidant MitoTEMPOL effectively eliminated these negative effects of Nrf2 silencing in HK-2 cells under PA stimulation. Moreover, activation of the Nrf2/ARE signaling pathway with tBHQ attenuated renal injury, significantly reduced mtROS generation, and improved mitochondrial function in rats with HFD-induced obesity. Taken together, these results suggest that the Nrf2/ARE-mediated antioxidant response plays a protective role in hyperlipidemia-induced renal injury by ameliorating mtROS-mediated mitochondrial dysfunction and that enhancing Nrf2 antioxidant signaling provides a potential therapeutic strategy for kidney injury in CKD with hyperlipidemia.
Protein arginine methyltransferase 3 inhibits renal tubulointerstitial fibrosis through asymmetric dimethylarginine
Authors: Wang Yanzhe , Wu Ming , Yang Feng , Lin Junyan , Zhang Li , Yuan Meijie , Chen Dongping , Tan Bo , Huang Di , Ye Chaoyang
Published: September 2022

Mammalian protein arginine methyltransferase 3 (PRMT3) catalyzes the monomethylation and dimethylation of the arginine residues of proteins. The role of PRMT3 in renal fibrosis is currently unknown. We aimed to study the role of PRMT3 in renal fibrosis and explored its underlying mechanisms. Quantitative PCR analysis and Western blotting analysis showed that the expression of PRMT3 was up-regulated in unilateral ureteral obstruction (UUO) mouse kidneys. Knockout of Prmt3 gene enhanced interstitial fibrosis in UUO kidneys as shown by Masson staining and Western blotting analysis the expression of pro-fibrotic markers. The production of asymmetric dimethylarginine (ADMA) was increased in wide type UUO kidneys but not further increased in Prmt3 knockout UUO kidneys. Administration of exogeneous ADMA in UUO kidneys blocked the enhanced renal interstitial fibrosis in Prmt3 mutant mice. Moreover, genetic deletion of Prmt3 gene increased blood urea nitrogen levels and renal deposition of collagen in folic acid injected mice. We conclude that PRMT3 inhibits renal tubulointerstitial fibrosis through elevating renal ADMA levels.
The exploration of anti-Vibrio parahaemolyticus substances from Phellodendri Chinensis Cortex as a preservative for shrimp storage
Authors: Zheng Huifang , Liu Yang , Cai Jing , Zhang Miao , Wen Ying , Guo Lei
Published: September 2022

This study aimed to optimize the ultrasonic-assisted extraction of the anti-Vibrio parahaemolyticus substances of Phellodendri Chinensis Cortex (ASPC), identify their active substances, and investigate their application in shrimp storage. The ultrasonic-assisted extraction conditions of ASPC were optimized through a single-factor experiment combined with response surface methodology. The optimal parameters were the ethanol concentration of 81%, the ultrasonic power of 500 W, the temperature of 80°C, the extraction time of 23 min, and the liquid/solid ratio 25 ml/g. The antibacterial zone diameter of the obtained extract determined by agar well diffusion method was 15.56 ± 0.22 mm, which was not significantly different from the predicted value (15.92 mm). Berberine was identified as one of the main chemical components of ASPC through high-performance liquid chromatography combined with standard control. The minimum inhibitory concentrations of ASPC and berberine determined by the tube dilution method were 0.25 and 0.03 mg/ml, respectively. The application of ASPC in shrimp storage showed that it could effectively inhibit the proliferation of V. parahaemolyticus on shrimps. This report offers good prospects for the use of Phellodendri Chinensis Cortex as a potential preservative against V. parahaemolyticus in aquatic products.
Ruminal background of predisposed milk urea (MU) concentration in Holsteins
Authors: Honerlagen Hanne , Reyer Henry , Segelke Dierck , Müller Carolin Beatrix Maria , Prahl Marie Christin , Ponsuksili Siriluck , Trakooljul Nares , Reinsch Norbert , Kuhla Björn , Wimmers Klaus
Published: September 2022

Efforts to reduce nitrogen (N) emissions are currently based on the optimization of dietary- N supply at average herd N requirements. The implementation of the considerable individual differences and predispositions in N- use efficiency and N- excretion in breeding programs is hampered by the difficulty of data collection. Cow individual milk urea (MU) concentration has been proposed as an easy-to-measure surrogate trait, but recent studies questioned its predictive power. Therefore, a deeper understanding of the biological mechanisms underlying predisposed higher (HMUg) or lower (LMUg) MU concentration in dairy cows is needed. Considering the complex N- metabolism in ruminants, the distinction between HMUg and LMUg could be based on differences in (i) the rumen microbial community, (ii) the host-specific transcription processes in the rumen villi, and (iii) the host–microbe interaction in the rumen. Therefore, rumen fluid and rumen epithelial samples from 10 HMUg and 10 LMUg cows were analyzed by 16S sequencing and HiSeq sequencing. In addition, the effect of dietary-N reduction on ruminal shifts was investigated in a second step. In total, 10 differentially abundant genera (DAG) were identified between HMUg and LMUg cows, elucidating greater abundances of ureolytic Succinivibrionaceae_UCG-002 and Ruminococcaceae_unclassified in LMUg animals and enhanced occurrences of Butyvibrio in HMUg cows. Differential expression analysis revealed genes of the bovine Major Histocompatibility Complex (BOLA genes) as well as MX1, ISG15, and PRSS2 displaying candidates of MU predisposition that further attributed to enhanced immune system activities in LMUg cows. A number of significant correlations between microbial genera and host transcript abundances were uncovered, including strikingly positive correlations of BOLA-DRA transcripts with Roseburia and Lachnospiraceae family abundances that might constitute particularly prominent microbial–host interplays of MU predisposition. The reduction of feed-N was followed by 18 DAG in HMUg and 19 DAG in LMUg, depicting pronounced interest on Shuttleworthia, which displayed controversial adaption in HMUg and LMUg cows. Lowering feed-N further elicited massive downregulation of immune response and energy metabolism pathways in LMUg. Considering breeding selection strategies, this study attributed information content to MU about predisposed ruminal N-utilization in Holstein–Friesians.
Enhancing egg production and quality by the supplementation of probiotic strains (Clostridium and Brevibacillus) via improved amino acid digestibility, intestinal health, immune response, and antioxidant activity
Authors: Obianwuna Uchechukwu Edna , Qiu Kai , Chang Xin-yu , Zhang Hai-jun , Wang Jing , Qi Guang-hai , Sun Tie-hu , Su Yong-bo , Wu Shu-geng
Published: September 2022

This study focused on evaluating the influence of Clostridium butyricum and Brevibacillus strains on egg production, egg quality, immune response and antioxidant function, apparent fecal amino acid digestibility, and jejunal morphology when supplemented as probiotics in the diets of laying hens in the peak phase. A total of 288 healthy 30-week-old Hy-Line Brown laying hens were arbitrarily assigned to four dietary groups, which included control diet and control diet supplemented with 0.02% C. butyricum zlc-17, C. butyricum lwc-13, or Brevibacillus zlb-z1, for 84 days. The results showed that dietary C. butyricum and Brevibacillus sp. exerted a positively significant influence (P ≤ 0.05) compared to the control group on the performance, egg quality, and physiological response of the birds. The diets could reduce mortality rate and enhance (P ≤ 0.05) egg weight and egg mass, egg production rate, and feed efficiency. Further analysis suggested that the probiotic strains can enhance (P ≤ 0.05) eggshell quality, Haugh unit, thick albumen content, and albumen height. Also, probiotics enhanced (P ≤ 0.05) the antioxidant status via increased antioxidant enzymes and jejunal morphology as evidenced by increased villi surface area (VSA), the ratio of villi height to crypt depth, villi width, and villi height, and a significant reduction in crypt depth. Besides, nutrient absorption and retention were enhanced, as apparent fecal amino acid digestibility of key essential amino acids was substantially improved in the diet-based group. The concentrations of immunoglobulin M and A (IgM and IgA) increased significantly (P ≤ 0.05) in the probiotics group and the same effect was notable for complement proteins (C3) and immune organ (Spleen). Conclusively, the supplementation of Clostridium butyricum zlc-17 in comparison to Clostridium butyricum lwc-13 and Brevibacillus zlb-z1 strains significantly (P ≤ 0.05) promoted the antioxidant status, modulated the intestinal structure, enhanced amino acid digestibility, and regulated the immunity index of the laying hens, which finally improves the laying performance and egg quality of the laying hens.
Dynamic Modelling of DNA Repair Pathway at the Molecular Level: A New Perspective
Authors: Lecca Paola , Ihekwaba-Ndibe Adaoha E. C.
Published: September 2022

DNA is the genetic repository for all living organisms, and it is subject to constant changes caused by chemical and physical factors. Any change, if not repaired, erodes the genetic information and causes mutations and diseases. To ensure overall survival, robust DNA repair mechanisms and damage-bypass mechanisms have evolved to ensure that the DNA is constantly protected against potentially deleterious damage while maintaining its integrity. Not surprisingly, defects in DNA repair genes affect metabolic processes, and this can be seen in some types of cancer, where DNA repair pathways are disrupted and deregulated, resulting in genome instability. Mathematically modelling the complex network of genes and processes that make up the DNA repair network will not only provide insight into how cells recognise and react to mutations, but it may also reveal whether or not genes involved in the repair process can be controlled. Due to the complexity of this network and the need for a mathematical model and software platform to simulate different investigation scenarios, there must be an automatic way to convert this network into a mathematical model. In this paper, we present a topological analysis of one of the networks in DNA repair, specifically homologous recombination repair (HR). We propose a method for the automatic construction of a system of rate equations to describe network dynamics and present results of a numerical simulation of the model and model sensitivity analysis to the parameters. In the past, dynamic modelling and sensitivity analysis have been used to study the evolution of tumours in response to drugs in cancer medicine. However, automatic generation of a mathematical model and the study of its sensitivity to parameter have not been applied to research on the DNA repair network so far. Therefore, we present this application as an approach for medical research against cancer, since it could give insight into a possible approach with which central nodes of the networks and repair genes could be identified and controlled with the ultimate goal of aiding cancer therapy to fight the onset of cancer and its progression.
Iron deposition heterogeneity in extrapyramidal system assessed by quantitative susceptibility mapping in Parkinson’s disease patients with type 2 diabetes mellitus
Authors: Li Wanyao , Gao Bingbing , Du Wei , Jiang Yuhan , Yang Jing , Hu Rui , Liu Yangyingqiu , Liu Na , Zhang Yukun , Song Qingwei , Miao Yanwei
Published: September 2022

Purpose

Excessive brain iron depositions were found in both patients with Parkinson’s disease (PD) and those with type 2 diabetes mellitus (T2DM). The present study aimed to explore iron deposition and heterogeneity in the extrapyramidal system in PD patients with T2DM using quantitative susceptibility mapping (QSM) and further to reveal the effect of T2DM on the changes in brain iron in patients with PD.

Materials and methods

A total of 38 PD patients with T2DM (PDDM), 30 PD patients without T2DM (PDND), and 20 asymptomatic control subjects (CSs) were recruited for this study. All subjects underwent multiple MRI sequences involving enhanced gradient echo T2 star weighted angiography (ESWAN). The magnetic sensitivity values (MSV) and volume of the whole nuclei (MSVW, VW) and high iron region (MSVRII, VRII) were measured on the bilateral caudate nucleus (CN), the putamen (PUT), the globus pallidus (GP), the substantia nigra (SN), the red nucleus (RN) and the dentate nucleus (DN). Clinical and laboratory data were recorded, especially for the Hoehn and Yahr (H-Y) stage, the Montreal Cognitive Assessment (MoCA), the Mini-Mental State Examination (MMSE), the Hamilton Depression Rating Scale (HAMD), and the Hamilton Anxiety Rating Scale (HAMA). All QSM data were compared between PDDM and PDND groups and correlated with clinical and laboratory data.

Results

Compared to the PDND group, the VRII/VW of the left CN was significantly increased in the PDDM group. Significantly higher MSVW and MSVRII were also found in the PDDM group, including bilateral SN of MSVW, right PUT, and bilateral CN, GP, and SN of MSVRII. The H-Y stage of the PDDM group was significantly higher than that of the PDND group. The MSVRII of bilateral RN of the PDDM group was positively correlated with the HAMA scores. HDL, DBP, and SBP levels were associated with MSVRII of right CN in the PDDM group.

Conclusion

T2DM could aggravate the disease severity and anxiety in patients with PD. The iron distribution of deep gray matter nuclei in PD patients with T2DM was significantly heterogeneous, which was related to blood pressure and blood lipids.
Physical activity and the development of general mental health problems or attention-deficit hyperactivity disorder (ADHD) symptoms in children and adolescents: A cross-lagged panel analysis of long-term follow-up epidemiological data
Authors: Ganjeh Parisa , Hagmayer York , Meyer Thomas , Kuhnert Ronny , Ravens-Sieberer Ulrike , von Steinbuechel Nicole , Rothenberger Aribert , Becker Andreas
Published: September 2022

Studies have shown that physical activity (PA) can provide a helpful, low-risk, and cost-effective intervention for children and adolescents suffering from mental health problems. This longitudinal study aimed to assess whether PA prevents the development of mental health problems, such as attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. Data were analyzed from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) collected from more than 15.000 children and adolescents at three different time points over a period of more than 10 years. Parents scored the PA of the study participants on three frequency levels according to WHO recommendations, and mental health problems were assessed by means of the Strengths and Difficulties Questionnaire (SDQ). The total problem score (SDQ-Total) and the hyperactivity/inattention symptoms sub-scale (SDQ-H/I) were used in an autoregressive cross-lagged model to examine their relationship with PA. The results showed that PA of boys and girls at preschool age was inversely associated with the occurrence of mental health problems and, in particular, ADHD symptoms about 6 years later. Higher levels of PA were associated with better general mental health and fewer ADHD symptoms at the next time point (Wave 1). These effects were not observed from preadolescence (Wave 1) to adolescence (Wave 2), neither for girls nor for boys. These findings indicate that medium-to-high PA may be a supportive factor for good mental health in children in preschool and elementary school. Future studies will have to show whether PA may be a helpful add-on for interventional programs for improving general mental health and alleviating ADHD symptoms among children and adolescents.
Risk Factors of Residual Dizziness After Successful Treatment for Benign Paroxysmal Positional Vertigo in Middle-Aged and Older Adults
Authors: Fu Wei , He Feng , Bai Ya , An Xinyue , Shi Ying , Han Junliang , Wang Xiaoming
Published: September 2022

Objective

The purpose of this study was to analyze risk factors of residual dizziness (RD) after successful treatment for benign paroxysmal positional vertigo (BPPV) in middle-aged and older adults.

Methods

181 patients with BPPV, after successful canalith repositioning maneuver (CRM) treatment, were recruited. All patients were divided into the middle-aged group (aged 45–59 years, n = 101) and the older group (over 60 years, n = 80). The clinical characteristics were recorded, including age, gender, numbers of maneuvers, involved canal, affected side, RD, comorbidities, dizziness handicap inventory score, and generalized anxiety disorder's 7-item scale score.

Results

The incidence of RD in the older group was significantly higher than that of the middle-aged group (p = 0.033). Multivariate logistic regression analysis shows that age (odds ratio = 1.042, p = 0.006), moderate to severe dizziness (odds ratio = 2.017, p = 0.034), and moderate to severe anxiety (odds ratio = 2.228, p = 0.017) were independently associated with RD in middle-aged and older adults.

Conclusion

Older adults exhibited higher incidence of RD after successful treatment for BPPV. Age, moderate to severe dizziness, and moderate to severe anxiety were independent risk factors of RD in middle-aged and older adults.
Physical activity, memory function, and hippocampal volume in adults with Down syndrome
Authors: Peven Jamie C. , Handen Benjamin L. , Laymon Charles M. , Fleming Victoria , Piro-Gambetti Brianna , Christian Bradley T. , Klunk William , Cohen Ann D. , Okonkwo Ozioma , Hartley Sigan L.
Published: September 2022

Higher engagement in moderate-intensity physical activity (PA) is related to better cognitive functioning in neurotypical adults; however, little is known about the effect of PA on cognitive aging in adults with Down syndrome (DS). Individuals with DS have three copies of chromosome 21, which includes the gene involved in the production of the amyloid precursor protein, resulting in an increased risk for an earlier onset of Alzheimer’s disease (AD). The goal of this study was to understand the relationship between engagement in moderate PA, memory, and hippocampal volume in adults with DS. Adults with DS participated in an ancillary Lifestyle study linked to the Alzheimer’s Biomarkers Consortium for DS (ABC- DS; N = 71). A within-sample z-score memory composite was created from performance on the Cued Recall Test (CRT) and the Rivermead Picture Recognition Test. Participants wore a wrist-worn accelerometer (GT9X) to measure PA. Variables of interest included the average percentage of time spent in moderate PA and average daily steps. Structural MRI data were acquired within 18 months of actigraphy/cognitive data collection for a subset of participants (n = 54). Hippocampal volume was extracted using Freesurfer v5.3. Associations between moderate PA engagement, memory, and hippocampal volume were evaluated with hierarchical linear regressions controlling for relevant covariates [age, body mass index, intellectual disability level, sex, and intracranial volume]. Participants were 37.77 years old (SD = 8.21) and were 55.6% female. They spent 11.1% of their time engaged in moderate PA (SD = 7.5%) and took an average of 12,096.51 daily steps (SD = 4,315.66). After controlling for relevant covariates, higher memory composite score was associated with greater moderate PA engagement (β = 0.232, p = 0.027) and more daily steps (β = 0.209, p = 0.037). In a subset of participants, after controlling for relevant covariates, PA variables were not significantly associated with the hippocampal volume (all p-values ≥ 0.42). Greater hippocampal volume was associated with higher memory composite score after controlling for relevant covariates (β = 0.316, p = 0.017). More PA engagement was related to better memory function in adults with DS. While greater hippocampal volume was related to better memory performance, it was not associated with PA. Greater PA engagement may be a promising lifestyle behavior to preserve memory in adults with DS.
Preparation and nutritional properties of xylooligosaccharide from agricultural and forestry byproducts: A comprehensive review
Authors: Yan Feng , Tian Shuangqi , Du Ke , Xue Xing'ao , Gao Peng , Chen Zhicheng
Published: September 2022

Xylooligosaccharide (XOS) are functional oligosaccharides with prebiotic activities, which originate from lignocellulosic biomass and have attracted extensive attention from scholars in recent years. This paper summarizes the strategies used in the production of XOS, and introduces the raw materials, preparation methods, and purification technology of XOS. In addition, the biological characteristics and applications of XOS are also presented. The most commonly recommended XOS production strategy is the two-stage method of alkaline pre-treatment and enzymatic hydrolysis; and further purification by membrane filtration to achieve the high yield of XOS is required for prebiotic function. At the same time, new strategies and technologies such as the hydrothermal and steam explosion have been used as pre-treatment methods combined with enzymatic hydrolysis to prepare XOS. XOS have many critical physiological activities, especially in regulating blood glucose, reducing blood lipid, and improving the structure of host intestinal flora.
Lowering serum homocysteine in H-type hypertensive patients with atrial fibrillation after radiofrequency catheter ablation to prevent atrial fibrillation recurrence
Authors: Dong Youzheng , Huang Ting , Zhai Zhenyu , Dong Quanbin , Xia Zhen , Xia Zirong , Yu Jianhua , Jiang Xinghua , Hong Kui , Wu Yanqing , Cheng Xiaoshu , Li Juxiang
Published: September 2022

Background

Prior investigation revealed that elevated serum total homocysteine (tHcy) are strongly correlated with atrial fibrillation (AF) recurrence. Herein, the goal of this study was to elucidate whether folic acid (FA) treatment reduced AF recurrence following radiofrequency catheter ablation (RFCA).

Methods

To conduct this retrospective research, we included consecutive H-type hypertensive AF patients, who were treated with first RFCA, between January 2010 and January 2022. We assessed the AF recurrence risk between patients who were taking 10 mg enalapril and 0.8 mg FA in a single-pill combination (enalapril–FA) daily and those who were taking a pill of 10 mg enalapril only. Outcomes were compared using the propensity-score matched analysis. Cox regression model was employed for the evaluation of AF recurrence events.

Results

Out of 2,714 patients, 645 patients receiving enalapril and 282 patients receiving enalapril-FA were included for analysis. Following propensity score matching, 239 patients remained in each group. These patients were followed-up for a median of 379 (137–596) days, and revealed that the enalapril-FA patients had drastically reduced AF recurrence, compared to the enalapril patients [adjusted hazard ratio (HR), 0.68; 95% confidence interval (CI), 0.48–0.97; P = 0.029]. Apart from this, no interactions were detected in the subgroup analysis.

Conclusion

In H-type hypertensive AF patients who were treated with first RFCA, FA supplementation was correlated with a reduced AF recurrence risk.
Case report: Pleural effusion during tyrosine-kinase inhibitor treatment in chronic myeloid leukemia: Not only a dasatinib-related adverse event
Authors: Pasquale Raffaella , Bucelli Cristina , Bellani Valentina , Zappa Manuela , Iurlo Alessandra , Cattaneo Daniele
Published: September 2022

The spectrum of TKI-related adverse events (AEs) is variable. Pleural effusion (PE) is a frequent AE attributable to dasatinib treatment, while it is only rarely associated with nilotinib. The pathogenetic mechanism leading to PE during nilotinib therapy is still unknown and its management has not yet been defined. To the best of our knowledge, only a limited number of similar case reports have already been reported in the literature so far. Here, we describe the case of a 41-year-old CML patient who developed PE during first-line nilotinib, successfully treated with steroids and nilotinib permanent discontinuation. We highlight the differences among our patient and the others, proposing therapeutic strategies to solve this rare but still possible AE, of which physicians should be aware.
Timing and intensity of physical activity and late sleeping habits among children in Japan
Authors: Matsuyama Yusuke , Isumi Aya , Doi Satomi , Shibata Ai , Ishii Kaori , Oka Koichiro , Fujiwara Takeo
Published: September 2022

Background

Little is known about what timing and intensity of physical activity (PA) are beneficial to preventing children’s late sleeping habits. We investigated the association between timing and intensity of PA and late sleeping habits among Japanese children.

Methods

The amount of PA on a weekday (light (>1.5 to <3.0 metabolic equivalents [METs]); moderate (3.0 to <6.0 METs); and vigorous (6.0 to <20.0 METs) was measured for the whole day, before school, during school, and after school, using accelerometers for population-based fourth-grade elementary school and eighth graders for 7 consecutive days between September and December 2018. Late sleeping habit (going to bed after 10 p.m. for fourth graders and after 11 p.m. for eighth graders) was assessed by questionnaires. The data of 229 fourth graders and 182 eighth graders were analyzed with Poisson regression adjusted for grade, gender, household income, body mass index (BMI), belonging to a sports club, wake-up time on weekdays, and PAs with different intensities.

Results

Total PA was not associated with late sleeping habits. Light-intensity PA before school was protectively associated with late sleeping habits (prevalence ratio [PR]: 0.82, 95% confidence interval [CI]: 0.68, 0.99) while PA at school or after school was not.

Conclusion

Light-intensity PA before school may enhance the earlier bedtime of children.
Overuse of medical care in paediatrics: A survey from five countries in the European Academy of Pediatrics
Authors: Jankauskaite Lina , Grechukha Yevgenii , Kjær Kristin Avranden , Mamenko Marina , Nakstad Britt , Romankevych Ivanna , Schnyder Sara , Selvakumar Joel , Trapani Sandra , Daniliaviciene Sandra , Valiulis Arunas , Wyder Corinne , Størdal Ketil
Published: September 2022

Studies and initiatives such as the “Choosing wisely” (CW) campaign emphasise evidence-based investigations and treatment to avoid overdiagnosis and overtreatment. The perception of the extent of medical overactivity among professionals and drivers behind are not well studied in the paediatric field.

Aim

We aimed to investigate the physicians‘ opinion and clarify the main drivers regarding medical overactivity in member countries of the European Academy of Paediatrics (EAP).

Methods

In this study, paediatricians, paediatric residents, primary care paediatricians, and family doctors treating children were surveyed in Norway, Lithuania, Ukraine, Italy, and Switzerland. Over-investigation was defined as “diagnostic work-up or referral that is unlikely to provide information which is relevant for a patient” and overtreatment was defined as “treatment that does not benefit or can harm more than benefit the patient.” The original questionnaire was developed in 2018 by a working group from the Norwegian Paediatric Association.

Results

Overall, 1,416 medical doctors participated in the survey, ranging from 144 in Lithuania to 337 in Switzerland. 83% stated that they experienced over-investigation/overtreatment, and 81% perceived this as a problem. The majority (83%) perceived expectations from family and patients as the most important driver for overtreatment in their country. Other drivers for overuse were use of national guidelines/recommendations, worry for reactions, and reduction of uncertainty.

Conclusion

This is the first study investigating knowledge and attitude toward medical overactivity in European countries. Despite different cultural and economic environments, the patterns and drivers of increased investigations and medicalisation are similar.
Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system
Authors: Luo Pan , Li Xuelin , Gao Yuan , Chen Zhengjun , Zhang Quanwei , Wang Zhimin , Tian Xiaozhu
Published: September 2022

The opioid system plays a crucial role in maintaining gastrointestinal homeostasis. Endogenous opioid peptide enkephalins have anti-inflammatory effect and participate in the treatment of inflammatory bowel diseases (IBDs). Here, we investigated the effect of natural enkephalinase inhibitor human opiorphin (HO) on dextran sodium sulfate (DSS)-induced colitis in mice. Our results showed that central administration of HO attenuated DSS-induced colitis, as indicated by the reduction of disease activity index (DAI) scores, macroscopic scores, histological scores, and the myeloperoxidase (MPO) activity. Moreover, HO alleviated DSS-induced inflammation by decreasing inflammatory cytokines TNF-α, IL-6, and IL-1β, and increasing anti-inflammatory cytokine IL-10 in both serum and colon tissues in DSS-treated mice. The potential anti-inflammatory effect of HO at a dose of 40 μg/kg was observed as evidenced by a decrease in nuclear factor κB (NF-κB) p65, toll-like receptor-4 (TLR-4), iNOS, and COX-2. HO also improved intestinal barrier function by enhancing the expression of tight junction proteins. Furthermore, HO treatment significantly inhibited activities of neutral endopeptidase (NEP) and aminopeptidase N (APN), elevated serum enkephalins concentrations, and increased expressions of mu and delta opioid receptors. In addition, pretreatment with opioid receptor antagonist naloxone hydrochloride (NH) compromised the protective effect of HO and aggravated colitis symptoms, as indicated by inhibited anti-inflammatory effects, disrupted intestinal barrier function, and decreased opioid receptor activity. In conclusion, these data indicate that HO protects against DSS-induced colitis by inhibiting TLR4/NF-κB pathway activation and improving intestinal barrier function through activation of the endogenous opioid system. Therefore, targeting the opioid system with peptidase inhibitors intervention would be a novel strategy in the therapy of IBD.
A bibliometric analysis of linguistic research on COVID-19
Authors: Peng Zhibin , Hu Zhiyong
Published: September 2022

Research on COVID-19 has drawn the attention of scholars around the world since the outbreak of the pandemic. Several literature reviews of research topics and themes based on scientometric indicators or bibliometric analyses have already been conducted. However, topics and themes in linguistic-specific research on COVID-19 remain under-studied. With the help of the CiteSpace software, the present study reviewed linguistic research published in SSCI and A&HCI journals to address the identified gap in the literature. The overall performance of the documents was described and document co-citations, keyword co-occurrence, and keyword clusters were visualized via CiteSpace. The main topic areas identified in the reviewed studies ranged from the influences of COVID-19 on language education, and speech-language pathology to crisis communication. The results of the study indicate not only that COVID-19-related linguistic research is topically limited but also that insufficient attention has been accorded by linguistic researchers to Conceptual Metaphor Theory, Critical Discourse Analysis, Pragmatics, and Corpus-based discourse analysis in exploring pandemic discourses and texts.
Emotion Analysis Based on Deep Learning With Application to Research on Development of Western Culture
Authors: Chen Ming
Published: September 2022

Cultural development is often reflected in the emotional expression of various cultural carriers, such as literary works, movies, etc. Therefore, the cultural development can be analyzed through emotion analysis of the text, so as to sort out its context and obtain its development dynamics. This paper proposes a text emotion analysis method based on deep learning. The traditional neural network model mainly deals with the classification task of short texts in the form of word vectors, which causes the model to rely too much on the accuracy of word segmentation. In addition, the short texts have the characteristics of short corpus and divergent features. A text emotion classification model combing the Bidirectional Encoder Representations from Transformers (BERT) and Bi-directional Long Short-Term Memory (BiLSTM) is developed in this work. First, the BERT model is used to convert the trained text into a word-based vector representation. Then, the generated word vector is employed as the input of the BiLSTM to obtain the semantic representation of the context of the relevant word. By adding random dropout, the mechanism prevents the model from overfitting. Finally, the extracted feature vector is input to the fully connected layer, and the emotion category to which the text belongs is calculated through the Softmax function. Experiments show that in processing short texts, the proposed model based on BERT-BiLSTM is more accurate and reliable than the traditional neural network model using word vectors. The proposed method has a better analysis effect on the development of western culture.
Maternal warmth is associated with network segregation across late childhood: A longitudinal neuroimaging study
Authors: Richmond Sally , Beare Richard , Johnson Katherine A. , Bray Katherine , Pozzi Elena , Allen Nicholas B. , Seal Marc L. , Whittle Sarah
Published: September 2022

The negative impact of adverse experiences in childhood on neurodevelopment is well documented. Less attention however has been given to the impact of variations in “normative” parenting behaviors. The influence of these parenting behaviors is likely to be marked during periods of rapid brain reorganization, such as late childhood. The aim of the current study was to investigate associations between normative parenting behaviors and the development of structural brain networks across late childhood. Data were collected from a longitudinal sample of 114 mother-child dyads (54% female children,Mage 8.41 years, SD = 0.32 years), recruited from low socioeconomic areas of Melbourne, Australia. At the first assessment parenting behaviors were coded from two lab-based interaction tasks and structural magnetic resonance imaging (MRI) scans of the children were performed. At the second assessment, approximately 18 months later (Mage 9.97 years, SD = 0.37 years) MRI scans were repeated. Cortical thickness (CT) was extracted from T1-weighted images using FreeSurfer. Structural covariance (SC) networks were constructed from partial correlations of CT estimates between brain regions and estimates of network efficiency and modularity were obtained for each time point. The change in these network measures, from Time 1 to Time 2, was also calculated. At Time 2, less positive maternal affective behavior was associated with higher modularity (more segregated networks), while negative maternal affective behavior was not related. No support was found for an association between local or global efficacy and maternal affective behaviors at Time 2. Similarly, no support was demonstrated for associations between maternal affective behaviors and change in network efficiency and modularity, from Time 1 to Time 2. These results indicate that normative variations in parenting may influence the development of structural brain networks in late childhood and extend current knowledge about environmental influences on structural connectivity in a developmental context.
Sex differences in emotional perception: Evidence from population of Tuvans (Southern Siberia)
Authors: Mezentseva A. A. , Rostovtseva V. V. , Ananyeva K. I. , Demidov A. A. , Butovskaya M. L.
Published: September 2022

Prior studies have reported that women outperform men in nonverbal communication, including the recognition of emotions through static facial expressions. In this experimental study, we investigated sex differences in the estimation of states of happiness, anger, fear, and disgust through static photographs using a two-culture approach. This study was conducted among the Tuvans and Mongolian people from Southern Siberia. The respondents were presented with a set of photographs of men and women of European and Tuvan origin and were asked to interpret each of them. They were asked: “What does the person in the photo feel?” We found that the Tuvans easily identified happiness and anger; however, the level of accuracy of fear and disgust recognition was low. No sex differences in the recognition of happiness, disgust, and fear were observed. However, anger recognition was significantly moderated by the perceiver’s sex and the origin of the model. Compared to Tuvan men, Tuvan women were significantly less accurate in identifying anger in male Tuvans. Furthermore, the age effect was found in recognition of fear: older Tuvans were more accurate while recognizing the fearful faces of Tuvan, but not the European models.