bluuebunny/crossref_metadata_2025 huggingface dataset:
USO DA PELE DE TILÁPIA PARA TRATAMENTO DE QUEIMADURAS: UMA REVISÃO INTEGRATIVA
Authors: Rotondano Filho Adriano Ferro , Cardoso Thais Carolina Alves , Costa Natália Sousa , Vitória Gustavo Urzêda , Mello Diego Antônio Calixto de Pina Gomes
Published: November 2021

Trata-se de uma revisão integrativa sobre o uso da pele de tilápia no tratamento de queimaduras. A pele de tilápia demonstrou em estudos histológicos, histoquímicos e tensiométricos ser passível de utilização como um fator protetor na medicina regenerativa. Uma vez que, apresenta características microscópicas semelhantes à estrutura morfológica da pele humana, além de possuir elevada resistência e elasticidade à tração. O colágeno presente em sua estrutura, estimula fatores de crescimento de fibroblastos, gerando padrão de cicatrização superior ao da pele nua, devido à sua capacidade de obstruir a ferida, minimizar exsudatos e a formação de crostas. Além disso, curativos biológicos e sólidos têm eficácia superior, em relação aos sintéticos, nos quesitos: menor tempo de fechamento de feridas, maior taxa de reepitelização e menor dor. Portanto, a pele de tilápia é um importante meio alternativo, no tratamento de queimadura, quando as técnicas de auto-enxerto não forem viáveis.
PREVALÊNCIA DE CINESIOFOBIA E FATORES ASSOCIADOS EM INDIVÍDUOS COM DOR LOMBAR
Authors: Costa Branco Jeronimo , Felin Cerezer Mariana , Bonaldo Rezende Gabriel , Saibt Martins Juliana , Soares Vieira Igor
Published: November 2021

Objetivo: Analisar a prevalência de cinesiofobia e comportamentos associados às maiores médias de cinesiofobia em indivíduos com dor lombar. Métodos: Estudo transversal, envolvendo indivíduos com diagnóstico de dor lombar que procuram atendimento fisioterapêutico vinculado ao Sistema Único de Saúde. Sendo aplicado um questionário para caracterizar a amostra. A Escala Visual Analógica para avaliar a intensidade da dor lombar e os questionários Internacional de Atividade Física e Roland Morris-Brasil para analisar o nível de atividade física e grau de incapacidade funcional. Por último, a Escala Tampa para cinesiofobia-Brasil foi aplicada para avaliar a presença e grau de cinesiofobia. Resultados: A amostra foi composta por 110 indivíduos com média de idade de 52,2 ± 12,2 anos, a maioria mulheres (74,5%). A média da intensidade da dor foi de 6,42 ± 2,26 e não houve correlação significativa entre o grau de cinesiofobia e a intensidade da dor (p=0,828 – r= -0,030). A prevalência de cinesiofobia foi de 78,2%, sendo que a maioria da amostra foi classificada com grau moderado. O escore médio de cinesiofobia foi de 45,4 ± 8,7, indivíduos sedentários (p = 0,026), com sobrepeso / obesidade (p = 0,039) e incapacidade funcional (p = 0,021) apresentaram as maiores médias de cinesiofobia. Considerações Finais: A prevalência de cinesiofobia é alta em indivíduos com dor lombar que procuram atendimento fisioterapêutico, estando associada ao nível de atividade física, incapacidade funcional e índice de massa corporal. Nível de Evidência II – Estudo Retrospectivo.
FATORES DE RISCO ASSOCIADOS AO NEAR MISS MATERNO EM UM HOSPITAL UNIVERSITÁRIO: ESTUDO DE CASO CONTROLE
Authors: Arantes Brenda Magalhães , Arantes Karen Magalhães , Freitas Efigênia Aparecida Maciel , Limongi Jean Ezequiel
Published: November 2021

RESUMOObjetivos: Esta pesquisa teve como objetivo analisar os fatores de risco associados ao near miss e óbito materno em um hospital de referência regional. Métodos: Trata-se de um estudo caso-controle de abordagem quantitativa e exploratória. Realizado busca de casos de near miss e óbito maternos em prontuários de pacientes internadas durante o ano de 2017 e que tiveram complicações obstétricas. Para cada caso de mulheres com desfecho materno grave, foram incluídos outros dois casos de mulheres internadas com a mesma idade para compor o grupo controle. Foram incluídos os casos de abortos, gravidez ectópica, molar e puérperas. Resultados: A Razão de near miss materno correspondeu a 18,82/ 1.000 nascidos vivos. Critérios clínicos foram mais frequentes (71,4%), seguido pelos critérios laboratoriais (42,8%) e de manejo (38,8%). Fatores de risco associados ao near miss e óbito materno foram a presença de diabetes mellitus tipo 1, hipertensão arterial gestacional, bem como a sobreposição de comorbidades. Intercorrências associadas foram hemorragias, pré-eclampsia grave, eclampsia e sepse. A internação em idade gestacional mais precoce e por motivo de complicação clínica-obstétrica ou fetal representaram riscos maiores. Considerações finais: Melhorar indicadores materno-infantis requer um sistema de saúde preparado para o atendimento da mulher, assim como envolve a participação intersetorial na busca de desenvolvimento social que melhore as condições de vida e saúde.
Inefetividade terapêutica de lamotrigina e manifestação de reação adversa prevista em bula: investigação de um potencial desvio da qualidade do medicamento
Authors: Eserian Jaqueline Kalleian
Published: November 2021

Este relato de caso descreve a investigação laboratorial realizada pela rede de vigilância sanitária de São Paulo em torno de uma suspeita de queixa técnica envolvendo inefetividade terapêutica de lamotrigina 100mg, medicamento similar, em alguns pacientes de um hospital universitário, a qual também mencionava manifestação de reação adversa prevista em bula. Tendo em vista a investigação de um potencial desvio da qualidade do medicamento, foram realizados ensaios de variação de peso, identificação e teor de lamotrigina, uniformidade de doses unitárias e dissolução nos comprimidos do lote investigado. Todos os ensaios realizados apresentaram resultados satisfatórios. Desta forma, conclui-se que o caso em questão não estava associado a desvios de qualidade do produto. A investigação de eventos adversos a medicamentos é bastante complexa, pois envolve diversos aspectos relacionados à farmacoterapia e ao paciente. Outras linhas devem ser investigadas para resolução do caso, principalmente aquelas focadas em aspectos relacionados à utilização do medicamento.
Mapeamento da Síndrome Inflamatória Multissistêmica Pediátrica associada à COVID-19 no Brasil
Authors: Lima Bruna Raynara Novais , Arrais Alexandre Oliveira , Oliveira Angela Maria Bezerra , Silva Cícero Lucas do Nascimento , Batista Maria Eduarda Teles , Cândido Estelita Lima
Published: November 2021

Objetivos: Analisar a distribuição de casos e óbitos por a Síndrome Inflamatória Multissistêmica Pediátrica (SIM-P), temporalmente associada à COVID-19, correlacionado com o sexo e a faixa etária, associando com a distribuição espacial em nível nacional, regional e estadual. Métodos: Realizou-se um estudo analítico retrospectivo dos dados disponibilizados sobre SIM-P presentes no 45º boletim epidemiológico de 2020. Resultados: A taxa de letalidade brasileira para a SIM-P foi de 6,85%, superando países desenvolvidos, como os Estados Unidos. Existe prevalência de casos e óbitos na faixa etária de 0 a 4 anos. A maioria dos casos acomete o sexo masculino, enquanto a mortalidade prevalece no feminino. As taxas de incidência foram mais elevadas no Norte e Nordeste, enquanto a letalidade prevaleceu no Norte e Sul, respectivamente. Em números absolutos, o Nordeste e Sudeste alcançaram os maiores números de casos e óbitos por SIM-P. Considerações Finais: É importante conhecer a epidemiologia associada com a SIM-P, visto que esses pacientes podem evoluir com choque e falência de múltiplos órgãos. Foi possível observar que disparidades já existentes previamente entre o Brasil e países desenvolvidos, e entre regiões com diferentes condições socioeconômicas no país, influenciaram taxas de letalidade, incidência e números absolutos. Ressalta-se a importância de políticas de saúde adequadas para prevenir esse drástico quadro de morbimortalidade no público pediátrico.
Ideias confinadas ou Minha janela se abriu pra praça: O fazer teatral online com estudantes da rede pública
Authors: Castilho Jacyan , Fogaça Marcos Clóvis
Published: November 2021

O artigo traz um relato da experiência de ensino em plataformas online para discentes do Ensino Fundamental II na cidade de Sorocaba, SP, realizada durante a pandemia de Covid-19 em 2020-21. Foi feita uma adaptação, para o ambiente virtual, de jogos teatrais presentes no fichário da autora Viola Spolin. A experiência instigou a proposição de uma encenação teatral virtual, intitulada “Minha janela se abriu pra praça”, aceita para ser desenvolvida no 20º FETO – Festival Estudantil de Teatro de Belo Horizonte, MG. O artigo explana a metodologia e resultados do processo com os estudantes, considerando os procedimentos sob a perspectiva da aprendizagem ativa, e considerando o ambiente remoto como dispositivo estruturador de linguagem.
Del templo al escenario digital: La danza clásica india en tiempos pandémicos
Authors: Lamas-Baiak Miriam
Published: November 2021

Este artículo trata de las acciones emprendidas por el medio digital, en relación a las danzas clásicas indias, en concreto, los estilos bharata natyam y kathak, como resultado de la crisis del COVID-19. Retrata los procesos desarrollados más allá de las clases remotas y de vídeos disponibles en internet, cómo, por ejemplo, a través de foros de debate, congresos, espacios para adquisición y distribución de contenidos e información. Finalmente, presenta la contribución de los medios digitales a la danza india en un contexto pandémico adverso, ampliando algunos territorios y delimitando otros ya existentes, abriendo todo un campo de investigación y creación que continúa a expandirse, creando un nuevo marco de producción y recepción para la danza india.
Incorporation et écologie sonore vidéoludiques : la marche sonore comme outil d’analyse
Authors: Meyer Charles
Published: November 2021

À partir d’une présentation des concepts d’écologie et de marche sonores ainsi que de leur application au jeu vidéo, cet article propose une méthode d’analyse sonore de jeu vidéo. À partir de deux marches sonores au sein d’une des zones jouables du jeuHorizon Zero Dawn(Guerrilla Software, Sony Interactive Entertainment, 2017) trois approches, politique, fonctionnelle et esthétique de l’écologie sonore étudiée sont développées. Si l’approche politique semble pertinente, les approches fonctionnelle et esthétique montrent les limites auxquelles cette méthode d’analyse sonore est confrontée. Des propositions visant à surmonter ces limites sont esquissées en conclusion.
Les cercueils de la maison funéraire Germain Lépine à Québec. La vitre du dernier regard : 1845-1945
Authors: Garneau Brigitte
Published: November 2021

L’auteure pose un regard neuf sur l’évolution des cercueils à Québec à partir du milieu du xixe siècle. Après avoir découvert deux spécimens en bois munis d’une vitre conservés de génération en génération par la famille de Cécile et Robert Lépine, elle consulte les archives de la maison funéraire Germain Lépine fondée en 1845 dans le quartier Saint-Roch et ayant eu sa place d’affaires au 715 rue Saint-Vallier Est jusqu’en 1975. Sa démarche permet de retracer différentes catégories de cercueils et de discerner le rôle que ceux-ci jouaient dans les rites mortuaires, notamment ceux des enfants et des adolescents.
Symbolique et destinée des « archives figurées » Robert-Lionel Séguin
Authors: Hamelin Louis-Edmond , Bouchard René , Massé Stéphanie
Published: November 2021

Louis Edmond-Hamelin est dans le dernier droit de son rectorat à l’Uqtr quand il prononce cette allocution, le 13 juin 1983, à
l’occasion de l’acquisition de la collection Robert-Lionel Séguin par son université. Plus
qu’un simple discours de circonstance, ce texte prend vite les allures d’un manifeste en
faveur d’une approche interdisciplinaire du champ des « Études québécoises ». Grâce à
l’immense valeur documentaire du fonds Séguin, le plus grand trésor de culture matérielle du
Québec, ce sont en effet trois siècles de culture francophonienne qui pourront être
approfondis. Cet exposé s’avère en même temps un programme de développement intellectuel de
cette collection monumentale qui touche le catalogage, l’enseignement au premier cycle, la
recherche et les études postérieures, la pédagogie muséologique et la collaboration
interinstitutionnelle. Ce texte fait l’objet d’une présentation contextuelle et d’un
appareil de notes qui en situent la portée institutionnelle novatrice et
originale.
L’harmonie de la musique et l’identité linguistique : l’a/r/tographie avec des futurs enseignants
Authors: Cormier Gail
Published: November 2021

En employant l’a/r/tographie, ce texte tissera le lien entre la musique et l’identité linguistique en éducation. À travers mes expériences en tant qu’enseignante du français au niveau secondaire en milieu minoritaire francophone au Canada et comme professeure à la Faculté d’éducation, j’évoque les possibilités de l’a/r/tographie et les risques de cette méthodologie. Exploiter la musique au moyen de l’a/r/tographie peut susciter un intérêt envers la langue française chez les élèves et les étudiants, pour ensuite contribuer à la valorisation de l’identité francophone. Ce parcours identitaire linguistique raconte la diversité des espaces dynamiques de l’enseignement et le potentiel d’échanges positifs dans ces espaces pour l’identité linguistique des futurs enseignants et des professeurs.
¡Te lo dije, Zuckerberg!
Authors:   Universitat Oberta de Catalunya, Lalueza Ferran
Published: November 2021

Está muy feo restregarle a alguien el consabido “«yo-ya-te-lo-dije»”, pero lo cierto es que yo ya lo dije. Pronostiqué que el Facebook que hemos conocido hasta ahora dejaría de existir en un plazo de entre tres y cuatro años, y lo pronostiqué hace exactamente tres años y ocho meses.
Entrepreneurial self-efficacy and entrepreneurial intention: The mediating role of the need for independence
Authors:   Lecturer, Department of Business Administration, Edo State University, Uzairue, Nigeria, e-mail: osadolor.victor@edouniversity.edu.ng, Osadolor Victor , Emmanuel Agbaeze Kalu ,   Professor of Entrepreneurship, Department of Management, University of Nigeria, Enugu, Nigeria, e-mail: emmanuel.agbaeze@unn.edu.ng, Emmanuel Isichei Ejikeme ,   Lecturer, Department of Business Administration, Federal University Wukari, Nigeria, e-mail: e.isichei@fuwukari.edu.ng, Taiwo Olabosinde Samuel ,   Lecturer, Department of Business Administration, Federal University Wukari, Nigeria, e-mail: olabosinde@yahoo.com
Published: November 2021

PURPOSE: The paper focuses on assessing the direct effect of entrepreneurial self-efficacy and entrepreneurial intention and the indirect effect of the need for independence on the relationship between the constructs. Despite increased efforts towards steering the interest of young graduates towards entrepreneurial venture, the response rate has been rather unimpressive and discouraging, thus demanding the need to account for what factors could drive intention towards venture ownership among graduates in Nigeria. METHODOLOGY: A quantitative approach was adopted and a data set from 235 graduates was used for the study. The data was analyzed using the partial least square structural equation model (PLS-SEM). FINDINGS: It was found that self-efficacy does not significantly affect intention. It was also found that the need for independence affects entrepreneurial intention. The study found that the need for independence fully mediates the relationship between entrepreneurial self-efficacy and entrepreneurial intention. PRACTICAL IMPLICATIONS: This paper provides new insight into the behavioral reasoning theory, through its application in explaining the cognitive role of the need for independence in decision-making, using samples from a developing economy. ORIGINALITY AND VALUE: The study advances a new perspective on the underlining factors that account for an entrepreneur’s intent to start a business venture, most especially among young graduates in Nigeria, through the lens of the behavioral reasoning theory. We further support the application of the theory in entrepreneurship literature, given the paucity of studies that have adopted the theory despite its relevance.
Dissipative linear response theory and its appications in open quantum systems
Authors: Chen Yu ,   Graduate School, China Academy of Engineering Physics, Beijing 100193, China
Published: November 2021

With the recent development of experimental technology, the ability to control the dissipation in quantum many-body system is greatly enhanced. Meanwhile, many new breakthroughs are achieved in detecting the quantum states and others. All these advances make it necessary to establish a new theory for calculating the dissipative dynamics in strongly correlated sstems. Very recently, we found that by taking the interactions between the system and the bath as a perturbation, a systematic dissipative response theory can be established. In this new approach, the calculation of dissipative dynamics for any physical observables and the entropies can be converted into the calculation of certain correlation functions in initial states. Then we discuss how Markovian approximation at low temperature limit and at high temperature limit can be reached Also, we review the progress of the dissipative dynamics in open Bose-Hubbard model. In the fourth section, we review recent progress of entropy dynamics of quench dynamics of an open quantum system. Finally, we draw a conclusion and discuss possible development in the future.
A small, computationally flexible network produces the phenotypic diversity of song recognition in crickets
Authors: Clemens Jan , Schöneich Stefan , Kostarakos Konstantinos , Hennig R Matthias , Hedwig Berthold
Published: November 2021

How neural networks evolved to generate the diversity of species-specific communication signals is unknown. For receivers of the signals, one hypothesis is that novel recognition phenotypes arise from parameter variation in computationally flexible feature detection networks. We test this hypothesis in crickets, where males generate and females recognize the mating songs with a species-specific pulse pattern, by investigating whether the song recognition network in the cricket brain has the computational flexibility to recognize different temporal features. Using electrophysiological recordings from the network that recognizes crucial properties of the pulse pattern on the short timescale in the cricket Gryllus bimaculatus, we built a computational model that reproduces the neuronal and behavioral tuning of that species. An analysis of the model’s parameter space reveals that the network can provide all recognition phenotypes for pulse duration and pause known in crickets and even other insects. Phenotypic diversity in the model is consistent with known preference types in crickets and other insects, and arises from computations that likely evolved to increase energy efficiency and robustness of pattern recognition. The model’s parameter to phenotype mapping is degenerate – different network parameters can create similar changes in the phenotype – which likely supports evolutionary plasticity. Our study suggests that computationally flexible networks underlie the diverse pattern recognition phenotypes, and we reveal network properties that constrain and support behavioral diversity.
Early evolution of beetles regulated by the end-Permian deforestation
Authors: Zhao Xianye , Yu Yilun , Clapham Matthew E , Yan Evgeny , Chen Jun , Jarzembowski Edmund A , Zhao Xiangdong , Wang Bo
Published: November 2021

The end-Permian mass extinction (EPME) led to a severe terrestrial ecosystem collapse. However, the ecological response of insects—the most diverse group of organisms on Earth—to the EPME remains poorly understood. Here, we analyse beetle evolutionary history based on taxonomic diversity, morphological disparity, phylogeny, and ecological shifts from the Early Permian to Middle Triassic, using a comprehensive new dataset. Permian beetles were dominated by xylophagous stem groups with high diversity and disparity, which probably played an underappreciated role in the Permian carbon cycle. Our suite of analyses shows that Permian xylophagous beetles suffered a severe extinction during the EPME largely due to the collapse of forest ecosystems, resulting in an Early Triassic gap of xylophagous beetles. New xylophagous beetles appeared widely in the early Middle Triassic, which is consistent with the restoration of forest ecosystems. Our results highlight the ecological significance of insects in deep-time terrestrial ecosystems.
One Genetic Defect and Two Related Entities in Monozygotic Twins: Otosclerosis and Superior Semicircular Canal Near Dehiscence Syndrome
Authors: Ocal F Ceyda Akin , Kavus Haluk , Satar Bulent , Pehli̇van Davut
Published: November 2021

The purpose of this study was to evaluate the clinical and genetic findings of 53-year-old monozygotic twins who had bilateral otosclerosis and right-sided superior semicircular canal near dehiscence (SSCND). Monozygotic twins at the age of 53 presented with conductive hearing loss and normal tympanic membranes. Detailed audiovestibular testing and computed tomography scan revealed that both patients had concurrent otosclerosis and SSCND. Conservative management (hearing aids) was the treatment for these patients. Exome sequencing (ES) for the twins and their affected mother identified a heterozygous missense variant in the EYA4 (c.1744G>A; p.Glu582Lys) gene. This is the first case report to present these separate entities identified in monozygotic twins with a heterozygous missense variant in the EYA4 gene. Our ES data may imply a possible causal relationship or association between variants in the EYA4 gene and concurrent otosclerosis and SSCND.
Determinants of Food Security Status and Coping Strategies to Food Insecurity among Rural Crop Farming Households in Ondo State, Nigeria
Authors: Ademola Adegoroye, , Adewale Isaac Olutumise, , Oluyede Adeleke Aturamu,
Published: November 2021

This study examined the food security status and coping strategies to food insecurity of rural arable crop farming households in Ondo State, Nigeria. Primary data were used and a multistage sampling procedure was used to select 150 respondents. Food Security Index (FSI), Probit regression model and Coping Strategy Use Index (CSUI) were employed to carry out the analysis. The empirical findings revealed that (54%) of rural arable crop farming households in the study area were food secure based on the recommended minimum calorie of 2260Kcal. Furthermore, the empirical analysis revealed that gender of the household head, household size, farm size and farm income of the household head had significant influence on the household food security status. The most widely employed coping strategy was withdrawal from personal savings as indicated by 14.82 percent of household and while reliance on less expensive food and purchasing food on credit were ranked second and third respectively with 13.66 and 12.85 percent by the food insecure households. In other to ensure sustainable food security among the households, the study recommended effective household size management, and enlightenment programmes on family planning in the study area. Farmers should increase their farm sizes. Farmers should use more inputs and technologies to increase output. Farmers should also be encouraged to have additional source of income towards attaining food security in the study area.
Available Nutrient Status of Soil as Influenced by Combined Application of Humic Acid and Inorganic Nitrogen
Authors: Manjeera K. Sai , Subbaiah P. Venkata , Prasad P. R. K. , Rekha M. Sree
Published: November 2021

A field experiment was carried out to study the influence of different levels of humic acid (10, 20, 30 kg ha-1) and inorganic N fertilizer viz., 100 % of recommended dose and 75 % of recommended dose on chemical properties of soil under direct sown rice at Agricultural college farm, Bapatla during 2019. The experiment was laid out in RBD with ten treatments replicated thrice with BPT-5204 variety of rice as test crop. Soil samples collected at tillering, panicle initiation and harvest stages of crop were analyzed for chemical properties like available N, P2O5, K2O, Sulphur and cationic micro-nutrients (Fe, Mn, Zn, Cu). Results indicated that increased availability of N, P2O5, K2O, Sulphur and cationic micro-nutrients (Fe, Mn, Zn, Cu) were observed with the treatment T6 involving 100% RDN and HA @ 30 kg ha-1.
Possibility of Using Bacteria-Destructors for Cypermetrin Degradation
Authors: Kosimov Diyorbek , Zaynitdinova Lyudmila , Jo’rayeva Roxila , Kukanova Svetlana , Ergashev Rustam , Mamadrakhimov Azimjon , Mutalliev Lukmonjon , Eshboev Farkhod
Published: November 2021

From soils artificially contaminated with cypermethrin, 3 isolates were obtained that were resistant to cypermethrin concentrations of 40 mg/kg soil, and their morphological, cultural and biochemical properties were studied. On the basis of the obtained strains, a bacterial consortium was developed, which consists of the cultures of Pseudomonas sp., Bacilus sp. and Ochrobactrum sp. Laboratory experiments on the decomposition of cypermethrin showed the effectiveness of this consortium, within 28 days the decomposition of cypermethrin (40 mg/kg) was 100%.
Regulation of Chloride Intracellular Channel Protein 1 and Caspase -3 mRNA Expression by Hydroethanolic Extract of Aegle marmelos Fruit Human Breast Cancer Cell Line-MCF-7
Authors: Dhivya S. , Devi R. Gayatri , Selvaraj J. , Priya A. Jothi
Published: November 2021

Introduction: Cancer is the second leading cause of death all over the world where among all types of cancer breast cancer is said to be the leading cancer followed by lung cancer. The aim of this study is to find the regulation of chloride intracellular channel protein 1 and caspase -3 mRNA expression by hydroethanolic extract of Aegle marmelos fruit human breast cancer cell line-MCF-7.

Materials and methods: MCF-7 cells were collected from NCCS Pune, India. It is stored in Dubecos Modified Eagle's Medium. The Aegle marmelos fruit was collected from the herbal department and its extract was prepared. The extract of Aegle marmelosis used in treating MCF-7 cells at different dosages in in vitro.  Isolation of total RNA from MCF-7 cells. The cells will be mixed with total RNA isolation reagent, sonicated and RNA will be isolated as per the standard method. c-DNA conversion and real time polymerase chain reaction. The c-DNA will be synthesized using reverse transcription by commercially available (RT-PCR) kit. Two microlitres of c-DNA will be used for amplification of clic-1 and caspase-3 using gene specific primers by commercially available RT-PCR kit (SyBr kit) and comparative CT method will be used to see the expression of genes. Untreated MCF-7 cells were compared with MCF-7 cells treated with various concentrations of the extract (10, 20 and 40ug). The statistical data’s were collected from the SPSS software version 21.

Result: The given extract inhibits the proliferation of MCF-7 cells therefore said to have antiproliferative activity. Different doses of extract were tested (200ug-500ug) out of which 400ug of extract were preferred.

Conclusion: The given plant extract has anti proliferative properties and hence can be used as a drug to treat breast cancer.
A Comparative Study of Antimicrobial Activity of Ethanolic Extract of Tecoma stans and Abutilon indicum Leaves: An In vitro Study
Authors: Binigha M. , Devi R. Gayatri , Selavaraj J. , Priya A. Jothi
Published: November 2021

Tecoma stans is a flowering plant belonging to the family Bignoniaceae. It is the floral emblem of the Bahamas. Abutilon indicum belongs to the family Malvaceae. It is also called Indian Mallow. Tecoma stans and Abutilon indicumhave antimicrobial activity and can be used in producing antibiotics. There is an urgent need to produce new antibiotics as there is an increase in the development of pathogen resistant drugs. The aim of this study was to compare the antimicrobial activity of ethanolic extract of Tecoma stansand Abutilonindicum leaves. E.faecalis bacteria were maintained in nutrient agar slopes. The powder of the two herbs, were subjected to extraction by Soxhlet extractor and was concentrated to dry residue by Agar well diffusion method. The nutrient broth was inoculated with bacterial strains. The culture was adjusted to 0.5McFarland turbidity standard. Lawn culture was done in Muller-Hinton agar plate and then the plates were dried. A 6 mm diameter well is bored for different concentrations. The extracts were introduced into the well and allowed to stand for 24 hrs. The antibacterial activity was determined by measuring the zone of inhibition. The present finding on the antimicrobial potential of Abutilon indicum and Tecoma stands showed that the two plants have growth inhibitory activity against oral pathogen E. faecalis. Abutilon indicum has a zone of inhibition greater than Tecoma stans. Abutilon indicum exhibited better activity compared to Tecoma stans.
In vitro Evaluation of Anti-Inflammatory Activity of Symplocos racemosa Using Protein Denaturation Assay
Authors: Janani K. , Geetha R. V. , Rajeshkumar S.
Published: November 2021

Introduction: Recently there is considerable awareness and interest in the field of herbal medicine due to its natural origin and lesser side effects compared to Allopathy. Selected herbal plants like Symplocos racemosa, commonly known as lodhra, are found mainly in plains and lower hills of Bengal. The word ‘Lodhra’ means ‘Propitious’. Symplocos racemosa is an important Indian traditional drug used in many Ayurvedic and herbal formulations for treatment of liver as well as uterine disorders and leucorrhea. Ethnobotanical Literature indicates use of Symplocos racemosa in treatment of eye disease, skin disease, ear disorders, liver and bowel complaints, tumours,uterine disorders, spongy and bleeding gums, asthma, fever, snakebite, gonorrhoea and arthritis.

Aim: To analyse the anti-inflammatory activity of Symplocos racemosa using protein denaturation assay.

Materials and Methods: 2 g of Lodhra bark powder is mixed with 100 ml distilled water & boiled for 20 min at 50°C. The extract is filtered using whatman filter paper & concentrated to 10 ml.1 ml each of Bovine serum albumin is added to various fixations of plant extract (10μL - 50 μL) and the anti - inflammatory activity was evaluated by analysing the percentage inhibition.

Results: From this study, it is evident that Lodhra has significant anti-inflammatory activity. At 50μℓ concentration, the plant extract shower higher anti- inflammatory activity of 76%.

Conclusion: Symplocos racemosa extract has proved to exhibit effective anti- inflammatory activity. Further studies have to be carried to analyse the other properties of this herb, which can be incorporated successfully in the pharmaceutical industry.
Fluctuation between cigarette smoking and use of electronic nicotine delivery systems: Impact on clozapine concentrations and clinical effect
Authors: Montville Daniel J. , Lindsey Jaclyn M. , Leung Jonathan G.
Published: November 2021

Unlike with smoking cigarettes, electronic nicotine delivery systems do not cause CYP450 1A2 induction as there is a lack of combustion and polycyclic aromatic hydrocarbon production. Changing to the use of an electronic nicotine delivery system from cigarettes can result in the deinduction of CYP450 1A2 and the increase of certain medication serum concentrations, including clozapine. A case is reported in which the switch from smoking to an electronic nicotine delivery system resulted in increased clozapine serum concentration and constipation, necessitating pharmacologic management. The patient ultimately transitioned back to cigarettes, which resulted in the emergence of psychiatric symptoms. An evaluation of longitudinal serum concentrations and clinical correlation is provided. It is important that patients and health care professionals have knowledge not only about the impact of smoking cigarettes on clozapine metabolism, but also the effects of switching to or from an electronic nicotine delivery system.
Biopsychosocial Rehabilitation for Inflammatory Arthritis and Osteoarthritis Patients: A Systematic Review and Meta‐Analysis of Randomized Trials
Authors: Pedersen Morten B. , Thinggaard Peter , Geenen Rinie , Rasmussen Marianne U. , Wit Maarten De , March Lyn , Mease Philip , Choy Ernest , Conaghan Philip G. , Simon Lee , Hansen Anne Faber , Tarp Simon , Schiøttz‐Christensen Berit , Juhl Carsten B. , Nielsen Sabrina M. , Amris Kirstine , Christensen Robin
Published: November 2021

Objective

To assess the benefits and harms associated with biopsychosocial rehabilitation in patients with inflammatory arthritis and osteoarthritis (OA).

Methods

We performed a systematic review and meta‐analysis. Data were collected through electronic searches of Cochrane CENTRAL, MEDLINE, Embase, PsycInfo, and CINAHL databases up to March 2019. Trials examining the effect of biopsychosocial rehabilitation in adults with inflammatory arthritis and/or OA were considered eligible, excluding rehabilitation adjunct to surgery. The primary outcome for benefit was pain and total withdrawals for harm.

Results

Of the 27 trials meeting the eligibility criteria, 22 trials (3,750 participants) reported sufficient data to be included in the quantitative synthesis. For patient‐reported outcome measures, biopsychosocial rehabilitation was slightly superior to control for pain relief (standardized mean difference [SMD] −0.19 [95% confidence interval (95% CI) −0.31, –0.07]), had a small effect on patient global assessment score (SMD –0.13 [95% CI –0.26, –0.00]), with no apparent effect on health‐related quality of life, fatigue, self‐reported disability/physical function, mental well‐being, and reduction in pain intensity ≥30%. Clinician‐measured outcomes displayed a small effect on observed disability/physical function (SMD −0.34 [95% CI −0.57, −0.10]), a large effect on physician global assessment score (SMD −0.72 [95% CI −1.18, −0.26]), and no effect on inflammation. No difference in harms existed in terms of the number of withdrawals, adverse events, or serious adverse events.

Conclusion

Biopsychosocial rehabilitation produces a significant but clinically small beneficial effect on patient‐reported pain among patients with inflammatory arthritis and OA, with no difference in harm. Methodologic weaknesses were observed in the included trials, suggesting low‐to‐moderate confidence in the estimates of effect.
Reversing AβFibrillation and Inhibiting AβPrimary Neuronal Cell Toxicity Using Amphiphilic Polyphenylene Dendrons
Authors: Xiang Siyuan , Wagner Jessica , Lückerath Thorsten , Müllen Klaus , Ng David Y. W. , Hedrich Jana , Weil Tanja
Published: November 2021

Uncontrolled amyloid‐beta (Aβ) fibrillation leads to the deposition of neurotoxic amyloid plaques and is associated with Alzheimer's disease. Inhibiting Aβmonomer fibrillation and dissociation of the formed fibers is regarded as a promising therapeutic strategy. Here, amphiphilic polyphenylene dendrons (APDs) are demonstrated to interrupt Aβassembly and reduce Aβ–cell interactions. Containing alternating negatively charged sulfonic acid and hydrophobic n‐propyl peripheral groups, APDs bind to the secondary structure of the Aβaggregates, inhibiting fibrillation and disassemble the already formed Aβfibrils. APDs reveal vesicular cellular uptake in endosomes as well as cell compatibility for endothelial and neuronal cells, and significantly reduce Aβ‐induced neuron cytotoxicity in vitro. Moreover, they are transported into the brain and successfully cross the blood–brain barrier after systemic application in mice, indicating their high potential to inhibit Aβfibrillation in vivo, which can be beneficial for developing therapeutic strategy for Alzheimer's disease.
An Inter‐Supplementary Biohybrid System Based on Natural Killer Cells for the Combinational Immunotherapy and Virotherapy of Cancer
Authors: Ding Li , Gao Qingqing , Xu Zhuobin , Cai Liangliang , Chen Sujuan , Zhang Xinyue , Cao Peng , Chen Gang
Published: November 2021

Oncolytic adenoviruses (Ads) have gained great attention in cancer therapy because they cause direct cytolytic infection and indirectly induce antitumor immunity. However, their efficacy is compromised by host antiviral immune response, poor tumor delivery, and the immunosuppressive tumor microenvironment (TME). Here, a natural killer (NK) cell‐mediated Ad delivery system (Ad@NK) is generated by harnessing the merits of the two components for combinational immunotherapy and virotherapy of cancer. In this biohybrid system, NK cells with a tumor‐homing tropism act as bioreactors and shelters for the loading, protection, replication, amplification, and release of Ads, thereby leading to a highly efficient systemic tumor‐targeted delivery. As feedback, Ad infection offers NK cells an enhanced antitumor immunity by activating type I interferon signaling in a STAT4‐granzyme B‐dependent manner. Moreover, it is found that the Ad@NK system can relieve immunosuppression in the TME by promoting the maturation of dendritic cells and the polarization of macrophages to M1 phenotype. Both in vitro and in vivo data indicate the excellent antitumor and antimetastatic functions of Ad@NKs by destroying tumor cells, inducing immunogenic cell death, and immunomodulating TME. This work provides a clinical basis for improved oncolytic virotherapy in combination with NK cell therapy based on the inter‐supplementary biohybrid system.
Deep‐Submicrometer Complementary Metal‐Oxide‐Semiconductor Transistors Based on Carbon Nanotube Films
Authors: Shi Huiwen , Ding Li , Zhong Donglai , Peng Lian‐Mao , Zhang Zhiyong
Published: November 2021

Semiconducting carbon nanotube (CNT) films are considered promising channel materials for constructing complementary metal‐oxide semiconducting (CMOS) field‐effect transistors (FETs) for future high‐performance integrated circuits (ICs). However, the poor performance of short channel n‐type FETs built on solution‐derived CNT films hinders the development of truly symmetric CMOS FETs, especially as the gate length scales down to the submicrometer region. The performance of short channel n‐type FETs is improved here by using scandium contacts accompanied by a doping channel and high‐performance and symmetrical CMOS FETs with a deep submicrometer gate length are fabricated for the first time. The n‐type and p‐type CNT FETs with a 150 nm gate length exhibit a maximum on‐state currentIonof ≈270 µA µm−1and a peak transconductancegmof over 100 µS µm−1, representing the best CNT CMOS FETs thus far. Digital circuit and system benchmarking with the Intel circuit model indicates that the deep‐submicrometer CNT CMOS FETs show great advantages over the previously reported CMOS ICs based on CNT FETs or other semiconducting film‐based FETs.
Strengthening the Sustainability of Additive Manufacturing through Data‐Driven Approaches and Workforce Development
Authors: Li Tianjiao , Yeo Jingjie
Published: November 2021

The additive manufacturing (AM) industry is rapidly developing and expanding, thereby becoming an important and integral component of the digital revolution in manufacturing practices. While the engineering aspects of AM are under intensive research, there still remain many chances to strengthen the sustainability of additive manufacturing (SAM). Cogently increasing the AM community's attention to SAM is vital for developing the AM industry sustainably from the bottom up. The digital nature of AM provides new opportunities for acquiring, storing, and utilizing data to strengthen SAM through data‐driven approaches. Herein, spotlight on SAM is shone upon and it is placed on a more concrete footing. The corresponding advances in data‐driven methods that can strengthen SAM are featured, such as optimizing designs for AM, reducing material waste, and developing databases. How the AM workforce can be developed and grown as a collaboration between the industry, government, and academia to extensively harness the full potential of AM as well as mitigate its adversarial social impact is discussed. Finally, several critical digital techniques that have the potential to further strengthen SAM in the factory of the future, including hybrid manufacturing, Internet of Things, and machine learning and artificial intelligence, are highlighted.
Surgical treatment of abdominal compression syndromes: The significance of hypermobility‐related disorders
Authors: Sandmann Wilhelm , Scholbach Thomas , Verginis Konstantinos
Published: November 2021

Case reports and systematic studies of the most common hypermobility‐related disorders, hypermobile Ehlers–Danlos syndrome (hEDS), and hypermobility spectrum disorder (HSD) typically describe gastroenterological symptoms and complaints attributed to structural malfunction, autonomic dysfunction, or inflammation of the gastrointestinal tract. However, abdominal compression syndromes (CS) may also contribute to pain and dysfunction in these individuals and be the leading pathology given symptoms significantly reduce or cease after decompressive surgery. Arising not only in the abdomen and causing pain (median arcuate ligament syndrome [MALS] and superior mesenteric artery syndrome [SMAS]), CS also occur in the retroperitoneum and the pelvis (nutcracker syndrome and May–Thurner syndrome), these latter conditions causing chronic pelvic congestion syndrome (PCS). Here, we report primarily on our experience of the assessment and management of MALS and SMAS in a cohort of cases with a surprising prevalence of HSD and hEDS. To our knowledge, this is the first cohort report of its kind in hEDS, HSD, and CS. We recommend that CS are considered in hEDS and HSD individuals with gastrointestinal and other painful complaints within the “belt” area. These CS can be identified using functional ultrasound duplex examination in experienced hands, and in appropriate cases stabilizing surgery can substantially improve quality of life.
Picolinamide‐Based Iridium Catalysts for Aqueous Formic Acid Dehydrogenation: Increase in Electron Density of Amide N through Substituents
Authors: Guo Jian , Yin Chengkai , Li Maoliang , Zhong Dulin , Zhang Yuguan , Li Xiaobin , Wang Yilin , Yao Hong , Qi Tiangui
Published: November 2021

Formic acid (FA) is considered to be a potential hydrogen storage material. Homogeneous catalysts are desired, which decompose aqueous FA into H2 and CO2 without addition of organic additives as they can contaminate the generated gas mixture. We report a new series of Cp*Ir (Cp*=pentamethylcyclopentadienyl) catalysts featuring picolinamide‐based ligands for efficient H2 generation from FA solution. Among them in‐situ generated catalyst from [Cp*Ir(H2O)3]SO4 and picolinohydroxamic acid (L3) achieved a high turnover frequency (TOF) of 90625 h−1 at 80 °C in 0.9 M FA solution and a turnover number (TON) of 120520 at 80 °C in a recycle experiment. The substituent effect of amide N atom was discussed and a plausible mechanism was proposed based on the experimental results.
How the Complex Network of Specklegram Deciphers Intra‐Film Thermal Induced Dynamics?
Authors: Sankararaman Sankaranarayana Iyer
Published: November 2021

The present work deciphers the potential of the graph and its features in the speckle‐based nondestructive evaluation of intra film thermal‐induced dynamics. The molybdenum oxide film, prepared by sputtering technique, containing nanorods is subjected to thermal stress from 30–50 °C and the specklegrams are recorded. The co‐occurrence matrix (CM) and heat map analyses of the specklegrams by dividing the temperature range into four intervals of 5 °C each reveal that the thermal stress drives the film from a less stable to a more stable state from the third to the fourth temperature interval. The CM analysis indicates the thermal‐induced rearrangements among the nanorods of the film. By extracting frames from the videograph of the speckle pattern during temperature variation, a complex network is constructed, taking the middle column of each frame as a node. The graph features also become minimum in the third interval and increase in the fourth interval revealing that the film moves to a more ordered state under thermal stress. The analysis of the specklegram by CM, heat map, and graph suggests that graph features present a high sensitivity compared to the other methods.
A Metal–Organic Framework as a Multiphoton Excitation Regulator for the Activation of Inert C(sp3)−H Bonds and Oxygen
Authors: Ji Guanfeng , Zhao Liang , Wei Jianwei , Cai Junkai , He Cheng , Du Zenggang , Cai Wei , Duan Chunying
Published: November 2021

The activation and oxidization of inert C(sp3)−H bonds into value‐added chemicals affords attractively economic and ecological benefits as well as central challenge in modern chemistry. Inspired by the natural enzymatic transformation, herein, we report a new multiphoton excitation approach to activate the inert C(sp3)−H bonds and oxygen by integrating the photoinduced electron transfer (PET), ligand‐to‐metal charge transfer (LMCT) and hydrogen atom transfer (HAT) events together into one metal‐organic framework. The well‐modified nicotinamide adenine dinucleotide (NAD+) mimics oxidized CeIII‐OEt moieties to generate CeIV‐OEt chromophore and its reduced state mimics NAD. via PET. The in situ formed CeIV‐OEt moiety triggers a LMCT excitation to form the alkoxy radical EtO., abstracts a hydrogen atom from the C(sp3)−H bond, accompanying the recovery of CeIII‐OEt and the formation of alkyl radicals. The formed NAD. activates oxygen to regenerate the NAD+ for next recycle, wherein, the activated oxygen species interacts with the intermediates for the oxidization functionalization, paving a catalytic avenue for developing scalable and sustainable synthetic strategy.
Studies on curing kinetics of polyphenylene sulfide: An insight into effects of curing temperature and time on structure and thermo‐mechanical behavior
Authors: Chen Guowei , Rodriguez‐Uribe Arturo , Wu Feng , Mohanty Amar K. , Misra Manjusri
Published: November 2021

Polyphenylene sulfide (PPS) is a type of thermoplastic that has high thermal and mechanical performances and extensive applications. Before processing, pre‐curing is required to improve its processability and mechanical properties. Here, effects of curing temperature (245 and 260°C) and time (10, 30, 60, and 120 min) on structure and thermal‐mechanical behavior of PPS were studied through melt flow index (MFI), rheology, Fourier‐transform infrared spectroscopy, and thermal‐mechanical characterizations. The MFI was decreased from ~700 g/10 min to less than 100 g/10 min (315°C/5.0 kg) after 60 min of curing at two different temperatures, greatly improving the processability of PPS in melt extrusion and injection molding processes. The functional groups remained unchanged after curing, due to the main reactions of chain extension and scission that occurred. For the PPS cured both at 245 and 260°C, the samples cured for 10 min displayed the highest degree of crystallinity and heat deflection temperature but had the lowest glass transition temperatures. The coefficient of linear expansion of PPS cured at 260°C showed anisotropy on flow and normal directions, which greatly differed from the PPS cured at 245°C. This study promotes an improved understanding of the curing process for solid PPS.