bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Hypoglycemia on Patients with Diabetes Mellitus: A Cross-Sectional Analysis
Authors: Agrawal Siddarth , Makuch Sebastian , Dróżdż Mateusz , Dudzik Tomasz , Domański Igor , Poręba Rafał , Mazur Grzegorz
Published: January 2022

The increasing mortality and morbidity in patients with diabetes mellitus constitute a severe public health problem. The condition is recognized as a cause of impaired quality of life, high costs, and diminished productivity. In this study, we performed a cross-sectional analysis among 300 Polish participants with type 1 and type 2 diabetes to determine and classify risk factors associated with increased incidences of hypoglycemia. Including an open-access knowledge about the correlations between diabetes rates and human’s lifestyle, we confirm that the frequency of smoking and drinking alcohol, low BMI, inappropriate diet, low physical activity, lack of vaccination against influenza and pneumococci, and co-existence of other comorbidities such as cardiovascular diseases, thyroid diseases, hyperlipidemia, retinopathy, and asthma elevate the risk of hypoglycemia. Furthermore, hypoglycemic patients were more often malnourished, depressed, irritated, and exposed to stress. In sum, the analysis of the interaction between diabetes and sociodemographic, environmental, or other disease-related risk factors provides strategies to optimize glycemic control and reduce the incidence of hypoglycemia. Furthermore, we believe our findings may constitute a basis for promoting health by adjusting available and implementing new preventive services reducing hypoglycemic episodes in diabetic patients.
Molecular Genetics Overview of Primary Mitochondrial Myopathies
Authors: Arena Ignazio Giuseppe , Pugliese Alessia , Volta Sara , Toscano Antonio , Musumeci Olimpia
Published: January 2022

Mitochondrial disorders are the most common inherited conditions, characterized by defects in oxidative phosphorylation and caused by mutations in nuclear or mitochondrial genes. Due to its high energy request, skeletal muscle is typically involved. According to the International Workshop of Experts in Mitochondrial Diseases held in Rome in 2016, the term Primary Mitochondrial Myopathy (PMM) should refer to those mitochondrial disorders affecting principally, but not exclusively, the skeletal muscle. The clinical presentation may include general isolated myopathy with muscle weakness, exercise intolerance, chronic ophthalmoplegia/ophthalmoparesis (cPEO) and eyelids ptosis, or multisystem conditions where there is a coexistence with extramuscular signs and symptoms. In recent years, new therapeutic targets have been identified leading to the launch of some promising clinical trials that have mainly focused on treating muscle symptoms and that require populations with defined genotype. Advantages in next-generation sequencing techniques have substantially improved diagnosis. So far, an increasing number of mutations have been identified as responsible for mitochondrial disorders. In this review, we focused on the principal molecular genetic alterations in PMM. Accordingly, we carried out a comprehensive review of the literature and briefly discussed the possible approaches which could guide the clinician to a genetic diagnosis.
Current Issues, Challenges, and Future Perspectives in Clinical Laboratory Medicine
Authors: Mannello Ferdinando , Plebani Mario
Published: January 2022

Laboratory medicine has undergone a profound evolution in organizational, methodological, and cultural terms in recent decades [...]
Expression and Function of Toll Pathway Components in the Early Development of the Wasp Nasonia vitripennis
Authors: Pers Daniel , Buchta Thomas , Özüak Orhan , Roth Siegfried , Lynch Jeremy A.
Published: January 2022

The Toll signaling pathway is the main source of embryonic DV polarity in the fly Drosophila melanogaster. This pathway appears to have been co-opted from an ancestral innate immunity system within the insects and has been deployed in different ways among insect taxa. Here we report the expression and function of homologs of the important components of the D. melanogaster Toll pathway in the wasp Nasonia vitripennis. We found homologs for all the components; many components had one or more additional paralogs in the wasp relative the fly. We also found significant deviations in expression patterns of N. vitripennis homologs. Finally, we provide some preliminary functional analyses of the N. vitripennis homologs, where we find a mixture of conservation and divergence of function.
Acknowledgment to Reviewers of Journal of Functional Biomaterials in 2021
Authors:   Journal of Functional Biomaterials Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Acknowledgment to Reviewers of Journal of Low Power Electronics and Applications in 2021
Authors:   Journal of Low Power Electronics and Applications Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
A Physics-Informed Neural Network for the Prediction of Unmanned Surface Vehicle Dynamics
Authors: Xu Peng-Fei , Han Chen-Bo , Cheng Hong-Xia , Cheng Chen , Ge Tong
Published: January 2022

A three-degrees-of-freedom model, including surge, sway and yaw motion, with differential thrusters is proposed to describe unmanned surface vehicle (USV) dynamics in this study. The experiment is carried out in the Qing Huai River and the data obtained from different zigzag trajectories are filtered by a Gaussian filtering method. A physics-informed neural network (PINN) is proposed to identify the dynamic models of the USV. PINNs combine the advantages of data-driven machine learning and physical models. They can also embed the speed and steering models into the loss function, which can significantly retain all types of information. Compared with traditional neural networks, the results show that the PINN has better generalization ability in predicting the surge and sway velocities and rotation speed with only limited training data.
Risk Assessment of Port Congestion Risk during the COVID-19 Pandemic
Authors: Gui Dongping , Wang Haiyan , Yu Meng
Published: January 2022

With the COVID-19 outbreak hitting the world, the frequency and severity of port congestion caused by various factors are increasing, challenging the stability of international supply chains. Thus, it is necessary to conduct an in-depth study on congestion risks to reduce their adverse impacts on congestion. Although traditional criticality analysis techniques may be capable of ranking port congestion risk in common scenarios, new risk analysis methods are urgently required to tackle uncertainty along with the COVID-19 pandemic. This paper develops a methodology designed for the identification and prioritization of port congestion risk during the pandemic. First, a novel congestion risk assessment model is established by extending the risk prioritization index (RPI) suggested by failure mode and effects analysis (FMEA). Next, the combination of fuzzy Bayesian reasoning, AHP and the variation coefficient method is incorporated into the model in a complementary way to facilitate the treatment of uncertainty and quantitative analysis of the congestion under the different influence of risk factors in ports. Finally, the mode introduces a set of risk utility values for calculating the RPI for prioritization. A real case study and a sensitivity analysis were carried out to illustrate and validate the proposed model. The results proved that the applied method is feasible and functional. In the illustrative example, the top three risk factors are “Interruption of railways/barges services”, “Skilled labor shortage” and “Shortage of truck-drivers/drayage truck”. The findings obtained from this paper could provide useful insights for risk prevention and mitigation.
Port Community Systems: Accelerating the Transition of Seaports toward the Physical Internet—The Portuguese Case
Authors: Caldeirinha Vítor , Nabais João Lemos , Pinto Cláudio
Published: January 2022

Supply chains are complex systems that have grown in dimension and spread worldwide. In supply chains, physical and information flows have strict service quality requirements, namely transparency conditions and traceability. Seaports, connecting land and maritime transport, are special components of supply chains where multiple players interact with different perspectives, and conflicting goals may arise. Port community authorities invest in electronic platforms to foster communication and integration with the companies that interact with the seaport, guiding the digitization of the seaport business. In main European and world ports, the Port Community System (PCS) is the platform that supports the creation of a network composed of shipping agents, shippers, freight forwarders, transporters, terminals, logistics platforms, and public entities. PCS focuses on service level, partner networks, maritime services, freight services, logistical services, and advanced port services. These features have an impact on seaport operations, which affects supply chain performance. Digitization within the scope of the PCSs has fostered the development of horizontal collaboration between seaport community partners. The Physical Internet (PI) is an innovative concept that seeks new logistics solutions requiring integration and interoperability between partners in the supply chain, including maritime and land transport. This paper focuses on (i) the evolution guidelines of PCSs and (ii) on the PCS Business Factors that can drive the supply chain into a significant improvement in performance. A survey was sent to a sample of Portuguese supply chain experts regarding the causal relationship between PCS Business Factors and supply chain performance in the next 10 to 20 years. From the data collected, recent services evolving at PCS are promoting a mindset change aligned to the implementation of a Physical Internet. Establishing a Physical Internal in Portuguese seaports could take decades, but it will support the transition to a new phase of PCS, accelerating the transition from Isolated Supply Chains (I-SCs) to Open Supply Chains (O-SCs), thus improving supply chain performance.
Genetic Algorithm for Sparse Optimization of Mills Cross Array Used in Underwater Acoustic Imaging
Authors: Teng Duo , Li Yatian , Yang Hu , Wei Zhiqiang , Li Yaan
Published: January 2022

Underwater acoustic imaging employs a special form of array which includes numerous transducer elements to achieve beamforming. Although a large-scale array can bring high imaging resolution, it will also cause difficulties in hardware complexity and real-time application. In this paper, in order to reduce the number of array elements, a sparse optimization for Mills cross is proposed, considering the elements’ distributions and weights design. The improved genetic algorithm is adopted to generate evolutions for sparse solution. In order to ensure effective convergence and successful evolution, relevant genetic operators are proposed, including appropriate population coding, correct fitness function, reasonable selection strategy and efficient two-point orthogonal crossover, among others. Essentially, a satisfied sparse solution is a result of mutual restraint between array elements’ survivals and their weights. The simulations reveal that our sparse cross array decreases the number of elements by 8.25% compared to the conventional Mills cross multiplicative array, while keeping the advantages of narrow main lobe width and low sidelobe level. Improved genetic algorithm is an effective method for the underwater acoustic imaging array to implement the sparse optimization.
Holoplanktonic and Meroplanktonic Larvae in the Surface Waters of the Onnuri Vent Field in the Central Indian Ridge
Authors: Kim Minju , Kang Jung-Hoon , Kim Dongsung
Published: January 2022

The dispersal of organisms in an isolated environment of a hydrothermal vent remains unclear. Here, we provide direct evidence that meroplanktonic larvae may migrate thousands of meters above the ocean floor. The morphological quantitative measurements of mesozooplankton were conducted in the Onnuri Vent Field (OVF), the Solitaire Fields (SF), and the reference site (ref-site). Only one species of bivalve larva that appeared at the OVF and the ref-site (0–200 m) was similar to Bathymodiolus spp. Sixteen species of gastropod larvae were distinguished, among which, species 1–4, 6, and 13 had holoplanktonic features (Atlanta, Oxygrus, and Limacina), whereas species 5, 7–12, and 14–16 had meroplanktonic features. Species 5, 11, and 12 appeared only at the OVF, 9 and 10 appeared only in the SF, 14–16 appeared only at the ref-site, and species 7 and 8 appeared in all surveyed stations. The species 5, 8, 12, 14, and 15 have morphological features similar to Vetulonia spp., and species 7 was similar to Lepetodrilidae; species 9–11 and 16 were similar to Phymorphynchus protoconchs. The morphologically distinguished mollusk larvae in the upper layers of the water column (0–200 m) indicate that larvae associated with deep-sea hydrothermal vents may disperse approximately 2000 m above the vents.
Fluid/Structure Interactions
Authors: Semenov Yuriy A.
Published: January 2022

This Special Issue contains 12 papers devoted to fluid/structure interaction (FSI) problems [...]
Fungal Proteases as Emerging Biocatalysts to Meet the Current Challenges and Recent Developments in Biomedical Therapies: An Updated Review
Authors: Naeem Muhammad , Manzoor Saba , Abid Mashhud-Ul-Hasan , Tareen Muhammad Burhan Khan , Asad Mirza , Mushtaq Sajida , Ehsan Nazia , Amna Dua , Xu Baojun , Hazafa Abu
Published: January 2022

With the increasing world population, demand for industrialization has also increased to fulfill humans’ living standards. Fungi are considered a source of essential constituents to produce the biocatalytic enzymes, including amylases, proteases, lipases, and cellulases that contain broad-spectrum industrial and emerging applications. The present review discussed the origin, nature, mechanism of action, emerging aspects of genetic engineering for designing novel proteases, genome editing of fungal strains through CRISPR technology, present challenges and future recommendations of fungal proteases. The emerging evidence revealed that fungal proteases show a protective role to many environmental exposures and discovered that an imbalance of protease inhibitors and proteases in the epithelial barriers leads to the protection of chronic eosinophilic airway inflammation. Moreover, mitoproteases recently were found to execute intense proteolytic processes that are crucial for mitochondrial integrity and homeostasis function, including mitochondrial biogenesis, protein synthesis, and apoptosis. The emerging evidence revealed that CRISPR/Cas9 technology had been successfully developed in various filamentous fungi and higher fungi for editing of specific genes. In addition to medical importance, fungal proteases are extensively used in different industries such as foods to prepare butter, fruits, juices, and cheese, and to increase their shelf life. It is concluded that hydrolysis of proteins in industries is one of the most significant applications of fungal enzymes that led to massive usage of proteomics.
Mechanisms of Trichoderma longibrachiatum T6 Fermentation against Valsa mali through Inhibiting Its Growth and Reproduction, Pathogenicity and Gene Expression
Authors: Zhu Na , Zhou Jing-Jiang , Zhang Shu-Wu , Xu Bing-Liang
Published: January 2022

Apple Valsa canker is one of the most serious diseases, having caused significant apple yield and economic loss in China. However, there is still no effective biological methods for controlling this disease. Our present study focused on the inhibitory activity and mechanisms of Trichoderma longibrachiatum (T6) fermentation on Valsa mali that causes apple Valsa canker (AVC). Our results showed that the T6 fermentation exhibited effective antifungal activity on the mycelial growth and conidia germination of V. mali, causing mycelium malformation and the hyphal disintegrating in comparison to the control. The activity of pathogenically related enzymes that are secreted from V. mali and the expression level of gene of V. mali were significantly inhibited and downregulated by treatment with T6 fermentation. In addition, the lesion area and number of pycnidia of V. mali formed on the branches were significantly reduced after treatment with the T6 fermentation through the pathogenicity test on the detached branches. Our results indicate that the possible mechanism of T6 fermentation against V. mali occurs through inhibiting its growth and reproduction, the pathogenic enzyme activity, and its related gene expression.
A Personalized Approach to Evaluating and Treating Autism Spectrum Disorder
Authors: Frye Richard E , Rose Shannon , Boles Richard G. , Rossignol Daniel A.
Published: January 2022

The most recent Center for Disease Control and Prevention estimates suggest that 1 in every 44 children (>2%) in the United States (US) is affected by autism spectrum disorder (ASD) [...]
Microphysiological Neurovascular Barriers to Model the Inner Retinal Microvasculature
Authors: Maurissen Thomas L. , Pavlou Georgios , Bichsel Colette , Villaseñor Roberto , Kamm Roger D. , Ragelle Héloïse
Published: January 2022

Blood-neural barriers regulate nutrient supply to neuronal tissues and prevent neurotoxicity. In particular, the inner blood-retinal barrier (iBRB) and blood–brain barrier (BBB) share common origins in development, and similar morphology and function in adult tissue, while barrier breakdown and leakage of neurotoxic molecules can be accompanied by neurodegeneration. Therefore, pre-clinical research requires human in vitro models that elucidate pathophysiological mechanisms and support drug discovery, to add to animal in vivo modeling that poorly predict patient responses. Advanced cellular models such as microphysiological systems (MPS) recapitulate tissue organization and function in many organ-specific contexts, providing physiological relevance, potential for customization to different population groups, and scalability for drug screening purposes. While human-based MPS have been developed for tissues such as lung, gut, brain and tumors, few comprehensive models exist for ocular tissues and iBRB modeling. Recent BBB in vitro models using human cells of the neurovascular unit (NVU) showed physiological morphology and permeability values, and reproduced brain neurological disorder phenotypes that could be applicable to modeling the iBRB. Here, we describe similarities between iBRB and BBB properties, compare existing neurovascular barrier models, propose leverage of MPS-based strategies to develop new iBRB models, and explore potentials to personalize cellular inputs and improve pre-clinical testing.
Precision Medicine for Hepatocellular Carcinoma: Clinical Perspective
Authors: Galun Danijel , Mijac Dragana , Filipovic Aleksandar , Bogdanovic Aleksandar , Zivanovic Marko , Masulovic Dragan
Published: January 2022

Hepatocellular carcinoma (HCC) is one of the major malignant diseases worldwide, characterized by growing incidence and high mortality rates despite apparent improvements in surveillance programs, diagnostic and treatment procedures, molecular therapies, and numerous research initiatives. Most HCCs occur in patients with liver cirrhosis, and the competing mortality risks from the tumor and the cirrhosis should be considered. Presently, previously identified risk factors, such as hepatitis virus infection, hepatic inflammation and fibrosis, and metabolic syndrome, may be used as chemoprevention targets. The application of precision medicine for HCC management challenges the one-size-fits-all concept; moreover, patients should no longer be treated entirely according to the histology of their tumor but based on molecular targets specific to their tumor biology. Next-generation sequencing emphasizes HCC molecular heterogeneity and aids our comprehension of possible vulnerabilities that can be exploited. Moreover, genetic sequencing as part of a precision medicine concept may work as a promising tool for postoperative cancer monitoring. The use of genetic and epigenetic markers to identify therapeutic vulnerability could change the diagnosis and treatment of HCC, which so far was based on Barcelona clinic liver cancer (BCLC) staging. In daily clinical practice, the shift from a stage-oriented to a therapeutic-oriented approach is needed to direct the choice of HCC treatment toward the potentially most effective option on an individual basis. The important factor in precision medicine is the promotion of patient management based on the individual approach, knowing that the final decision must be approved by a multidisciplinary expert team.
Novel KLK4 Mutations Cause Hypomaturation Amelogenesis Imperfecta
Authors: Lee Yejin , Zhang Hong , Seymen Figen , Kim Youn Jung , Kasimoglu Yelda , Koruyucu Mine , Simmer James P. , Hu Jan C.-C. , Kim Jung-Wook
Published: January 2022

Amelogenesis imperfecta (AI) is a group of rare genetic diseases affecting the tooth enamel. AI is characterized by an inadequate quantity and/or quality of tooth enamel and can be divided into three major categories: hypoplastic, hypocalcified and hypomaturation types. Even though there are some overlapping phenotypes, hypomaturation AI enamel typically has a yellow to brown discoloration with a dull appearance but a normal thickness indicating a less mineralized enamel matrix. In this study, we recruited four Turkish families with hypomaturation AI and performed mutational analysis using whole exome sequencing. These analyses revealed two novel homozygous mutations in the KLK4 gene: a nonsense mutation in exon 3 (NM_004917.4:c.170C>A, p.(Ser57*)) was found in families 1, 2 and 3 and a missense mutation in exon 6 (c.637T>C, p.(Cys213Arg)) in family 4. Functional analysis showed that the missense mutation transcript could not translate the mutant protein efficiently or generated an unstable protein that lacked functional activity. The two novel inactivating KLK4 mutations we identified caused a hypomaturation AI phenotype similar to those caused by the four previously described KLK4 nonsense and frameshift mutations. This study improves our understanding of the normal and pathologic mechanisms of enamel formation.
Impact of Increased End-Tidal Carbon Dioxide on Continuous Noninvasive Hemoglobin Monitoring during Laparoscopic Gastrectomy: A Randomized Controlled Study
Authors: Kim Ha-Yeon , Choi Jong-Bum , Han Sang-Uk , Lee Hye-Sun , Lee Kyuhyeok , Kim Ji-Eun
Published: January 2022

The pulse CO-Oximetry allows continuous, noninvasive monitoring of hemoglobin (SpHb). We assessed the impact of increased end-tidal carbon dioxide (EtCO2) on the accuracy and trending ability of SpHb in laparoscopic surgery. Participants (n = 64) were randomly allocated to the low carbon dioxide (CO2) group (EtCO2: 30–35 mmHg) or the high CO2 group (EtCO2: 40–45 mmHg). The SpHb and laboratory hemoglobin (tHb) were obtained during surgery. The correlation coefficient (r) between SpHb and tHb showed greater tendency in the low CO2 group (r = 0.68) than in the high CO2 group (r = 0.43). The bias (precision) was −1.18 (1.09) with a limit of agreement (LOA) of −3.31 to 0.95 in low CO2 group and −1.02 (1.24) with a LOA of −3.45 to 1.42 in high CO2 group; they did not differ significantly between the groups (p = 0.246). The low CO2 group showed a high concordance rate of 95.9% and a moderate correlation between ΔSpHb and ΔtHb (r = 0.53). However, the high CO2 group showed a concordance rate of 77.8% and no correlation between ΔSpHb and ΔtHb (r = 0.11). In conclusion, increased EtCO2 significantly reduced the trending ability of SpHb during laparoscopic surgery. Caution should be executed when interpreting SpHb values during laparoscopic surgery in patients with hypercapnia.
Long-Term Prognostic Impact of Right Ventricular Dysfunction in Patients with COVID-19
Authors: Scudiero Fernando , Silverio Angelo , Muraca Iacopo , Russo Vincenzo , Di Maio Marco , Silvestro Antonio , Personeni Davide , Citro Rodolfo , Canonico Mario Enrico , Galasso Gennaro , Porto Italo , Parodi Guido
Published: January 2022

The characteristics and clinical course of hospitalized patients with coronavirus disease 2019 (COVID-19) have been widely described, while long-term data are still poor. The aim of this study was to evaluate the long-term clinical outcome and its association with right ventricular (RV) dysfunction in hospitalized patients with COVID-19. This was a prospective multicenter study of consecutive COVID-19 patients hospitalized at seven Italian Hospitals from 28 February to 20 April 2020. The study population was divided into two groups according to echocardiographic evidence of RV dysfunction. The primary study outcome was 1-year mortality. The propensity score matching was performed to balance for potential baseline confounders. The study population consisted of 224 patients (mean age 69 ± 14, male sex 62%); RV dysfunction was diagnosed in 63 cases (28%). Patients with RV dysfunction were older (75 vs. 67 years, p < 0.001), had higher prevenance of coronary artery disease (27% vs. 11%, p = 0.003), and lower left ventricular ejection fraction (50% vs. 55%, p < 0.001). The rate of 1-year mortality (67% vs. 28%; p ≤ 0.001) was significantly higher in patients with RV dysfunction compared with patients without. After propensity score matching, patients with RV dysfunction showed a worse long-term survival (62% vs. 29%, p < 0.001). The multivariable Cox regression model showed an independent association of RV dysfunction with 1-year mortality. RV dysfunction is a relatively common finding in hospitalized COVID-19 patients, and it is independently associated with an increased risk of 1-year mortality.
Omalizumab: An Optimal Choice for Patients with Severe Allergic Asthma
Authors: Kotoulas Serafeim Chrysovalantis , Tsiouprou Ioanna , Fouka Eva , Pataka Athanasia , Papakosta Despoina , Porpodis Konstantinos
Published: January 2022

Omalizumab is the first monoclonal antibody that was globally approved as a personalized treatment option for patients with moderate-to-severe allergic asthma. This review summarizes the knowledge of almost two decades of use of omalizumab to answer some important everyday clinical practice questions, concerning its efficacy and safety and its association with other asthma-related and drug-related parameters. Evidence suggests that omalizumab improves asthma control and reduces the incidence and frequency of exacerbations in patients with severe allergic asthma. Omalizumab is also effective in those patients in reducing corticosteroid use and healthcare utilization, while it also seems to improve lung function. Several biomarkers have been recognized in predicting its efficacy in its target group of patients, while the optimal duration for evaluating its efficacy is between 16 and 32 weeks.
Sustainability Initiatives for Green Tourism Development: The Case of Wayanad, India
Authors: Markose Nimi , Vazhakkatte Tazhathethil Bindu , George Babu
Published: January 2022

Mainstream sustainability discussions draw focus to the balance between commercial and environmental interests. Responsible tourism (RT) practices are an outcome of these discussions and RT is a significant contributor to the “greenification” of economies in many countries. Green tourism promotes travel that supports natural and cultural aspirations, while also supporting protection of the destination community’s limited resources. Kerala, India, is a pioneer in implementing RT. The present study exploratively analyzes the RT initiatives at different phases, especially within the lens of sustainable responsible tourism initiatives for green tourism development. The research is descriptive in nature and is guided by the bottom line approach (TBL) for green economic development. The findings highlight the dynamics of challenges experienced in the different phases of RT implementation. Based on our analysis of the secondary data, the first phase implementation of RT was not very successful; the second and the third phases seemed to be more promising. The study also throws light on the need for future studies in other culturally distant destinations; this will result in promising practices being adopted as alternative strategies for sustainable tourism development globally.
Measuring the Financial Liberalization Index for Pakistan
Authors: Idrees Muhammad , Hayat Umar , Radulescu Magdalena , Alam Md Shabbir , Rehman Abdul , Panait Mirela
Published: January 2022

This paper aims to construct a bi-directional, financial liberalization index for Pakistan by considering various financial policy indicators (reforms). This study, by employing the principal component analysis method over a period of 1980–2018 (39 years), aims to determine the composite outcome in the case of developing a financial index. This study uses 14 financial policy indicators to investigate the degree of financial liberalization over a specified time period. The present study suggests a financial liberalization index for Pakistan considering the real-time change in the implementation process. The formulated index revealed that the recorded profitability of financial reforms was consistently high until 1998. Meanwhile, in the period from 1997 to 2003, the outcomes of financial reforms were surprisingly strong. Beyond 2004 and for the rest of the remaining years until 2018, the liberalization process recorded was comparatively slow. Thus, it was witnessed that all the key indicators, in the sense of regulation and liberalization, included determining the degree of financial liberalization. The consistency track of a liberalization index is a major focus of attention for policy makers, in order to capture the efficiency outcomes from various financial policy indicators, which were implemented beyond 2004. Furthermore, corporate risk in terms of better access to finance is also raised as a consequence of financial liberalization. Financial liberalization also resulted in a decrease in the cost of capital and improved the corporate governance.
Detailed Soil Survey Field and Laboratory Data as a Critical Tool for Optimizing the Arable Cropping Capability Evaluation of a Representative Episaturated Soil Pedon in Greece
Authors: Gasparatos Dionisios , Kairis Orestis
Published: January 2022

The objective of the present work is to contribute to the examination of the interconnections between soil classification/soil mapping and soil capability for agricultural use. A pedon scale analytical field along with laboratory data of an episaturated agricultural soil of Thessaly (Greece), allowed for the optimization of soil fertility class evaluation and its corresponding agricultural value. Specific soil properties, low chroma colors and the distribution of redoximorphic features within the soil profile (Fe-Mn concretions) revealed the presence of impermeable argillic horizons, resulting in a perched water table in late winter and spring. The evaluation of the soil pedon was carried out through the accurate parameterization and implementation of a technical soil classification system and a soil rating method, both of which are well known worldwide, and which use detailed soil survey data. The results confirmed the general principle that only by using detailed soil survey field and laboratory data can any technical soil classification system or soil rating method be adapted and properly applied. Both the classification system and the scoring methodology of the soil profile reached the same conclusion: characterizing the studied soil as of good potential for general arable cropping or as of fair agricultural value. This was achieved only by considering the phenomenon of episaturation, which emerged from the plethora of detailed soil survey data, guiding the classification system and the scoring methodology to produce reliability and represent real situation results.
Implementing a New Rubber Plant Functional Type in the Community Land Model (CLM5) Improves Accuracy of Carbon and Water Flux Estimation
Authors: Ali Ashehad A. , Fan Yuanchao , Corre Marife D. , Kotowska Martyna M. , Preuss-Hassler Evelyn , Cahyo Andi Nur , Moyano Fernando E. , Stiegler Christian , Röll Alexander , Meijide Ana , Olchev Alexander , Ringeler Andre , Leuschner Christoph , Ariani Rahmi , June Tania , Tarigan Suria , Kreft Holger , Hölscher Dirk , Xu Chonggang , Koven Charles D. , Dagon Katherine , Fisher Rosie A. , Veldkamp Edzo , Knohl Alexander
Published: January 2022

Rubber plantations are an economically viable land-use type that occupies large swathes of land in Southeast Asia that have undergone conversion from native forest to intensive plantation forestry. Such land-use change has a strong impact on carbon, energy, and water fluxes in ecosystems, and uncertainties exist in the modeling of future land-use change impacts on these fluxes due to the scarcity of measured data and poor representation of key biogeochemical processes. In this current modeling effort, we utilized the Community Land Model Version 5 (CLM5) to simulate a rubber plant functional type (PFT) by comparing the baseline parameter values of tropical evergreen PFT and tropical deciduous PFT with a newly developed rubber PFT (focused on the parameterization and modification of phenology and allocation processes) based on site-level observations of a rubber clone in Indonesia. We found that the baseline tropical evergreen and baseline tropical deciduous functions and parameterizations in CLM5 poorly simulate the leaf area index, carbon dynamics, and water fluxes of rubber plantations. The newly developed rubber PFT and parametrizations (CLM-rubber) showed that daylength could be used as a universal trigger for defoliation and refoliation of rubber plantations. CLM-rubber was able to predict seasonal patterns of latex yield reasonably well, despite highly variable tapping periods across Southeast Asia. Further, model comparisons indicated that CLM-rubber can simulate carbon and energy fluxes similar to the existing rubber model simulations available in the literature. Our modeling results indicate that CLM-rubber can be applied in Southeast Asia to examine variations in carbon and water fluxes for rubber plantations and assess how rubber-related land-use changes in the tropics feedback to climate through carbon and water cycling.
Long-Term Effect of Pig Slurry and Mineral Fertilizer Additions on Soil Nutrient Content, Field Pea Grain and Straw Yield under Winter Wheat–Spring Barley–Field Pea Crop Rotation on Cambisol and Luvisol
Authors: Hlisnikovský Lukáš , Menšík Ladislav , Čermák Pavel , Křížová Kateřina , Kunzová Eva
Published: January 2022

Different fertilizers have different effects on soil chemistry and crop yields. In this paper, we analyzed how long-term and regular application of mineral fertilizers, pig slurry and their combinations (15 fertilizer treatments totally) affect soil pH, nutrient content and yield of field pea at two sites with different soil (cambisol and luvisol) and climatic conditions. The long-term trials evaluated in this paper were established in 1972 at Pernolec and Kostelec, Czech Republic. Results of the soil analyses (evaluated period) are from the years 2015–2020, covering two sequences of crop rotation (winter wheat–spring barley–field pea). The fertilizer treatments significantly affected the soil reaction; application of mineral fertilizers and their combinations resulted in the lowest pH values. On the other hand, the same treatments provided the highest yields and left the highest pool of nutrients in the soil. Pig slurry can provide the same yields of field pea as mineral NPK fertilizers, without a negative effect on soil reaction. Analyzing the mineral fertilizers only, a reasonable dose of N (according to the linear-plateau model) can range from 73 and 97 kg ha−1 N in Pernolec, according to the weather conditions.
Residents’ Perceptions Regarding the Implementation of a Tourist Tax at a UNESCO World Heritage Site: A Cluster Analysis of Santiago de Compostela (Spain)
Authors: Soares Jakson Renner Rodrigues , Remoaldo Paula , Perinotto André Riani Costa , Gabriel Larissa Paola Macedo Castro , Lezcano-González María Elvira , Sánchez-Fernández María-Dolores
Published: January 2022

Even though the residents’ perceptions on the tourist activity have been thoroughly investigated in the last three decades, there are still few similar studies on destinations that are listed as UNESCO World Heritage Sites. The research presented in this article assesses the perception of the residents of the municipality of Santiago de Compostela (Spain) regarding the implementation of a tourist tax. The study is based on 588 residents’ responses to a survey conducted through a questionnaire prepared by the authors. Owing to the exponential increase in the number of visitor arrivals to the city, the implementation of a tourist tax could be one of the strategies deployed to improve the tourist experience. It may also allow for a less negative interaction between residents and tourists. The analysis revealed the existence of three clusters: tax-skeptics, tax-enthusiasts, and tax-reactionaries. The results are consistent with the nature of a mature destination, with most respondents supporting the implementation of a tourist tax that could contribute to improving, amongst other things, the quality of the tourist destination for both visitors and residents.
Ambiguous Outcomes of Returnees’ Land Dispute Resolution and Restitution in War-Torn Burundi
Authors: Tchatchoua-Djomo Rosine , van Dijk Han
Published: January 2022

Redressing land dispossession in the aftermath of violent conflicts is daunting and complex. While land dispute resolution and restitution are expected to promote return migration, this outcome is contingent upon the changing social, economic and political conditions under which return takes place. Drawing on qualitative data from Makamba Province in southern Burundi, this case study highlights the politically and historically shaped challenges underlying the resolution of competing and overlapping claims on land following protracted displacement. These include the undocumented and fluid nature of customary land rights, institutional and legal pluralism and shifting land governance relations. This paper emphasises the centrality of the state in regulating returnees’ land dispute resolution and restitution processes. Violent conflicts and forced migration have enabled the state to expand its control over customary land tenure. The gradual exclusion or replacement of local authorities has shaped a competitive structure of jurisdictions and confused authority over land. National land restitution commissions have been used by the central government to shape land tenure and state–citizen relations and to exert pressure on land tenure institutions. Addressing competing claims on land following armed conflicts may fail if attendant struggles over public authority and changing political dynamics are insufficiently considered.
Dynamic Landscapes in the UK Driven by Pressures from Energy Production and Forestry—Results of the CORINE Land Cover Map 2018
Authors: Cole Beth , Smith Geoff , de la Barreda-Bautista Bestabé , Hamer Alexandra , Payne Matthew , Codd Thomas , Johnson Sarah C. M. , Chan Lok Yung , Balzter Heiko
Published: January 2022

The CORINE Land Cover (CLC) map was established in 1985 and is now one of the most widely used products from the Copernicus Land Monitoring Service. As the world’s longest consistent operational land cover monitoring product, CLC maps have been produced for reference years 1990, 2000, 2006, 2012 and now for 2018. This paper presents the results from the CLC2018 mapping project in the UK and analyses the results of the land cover status layer and the change layer from the period 2012–2018. It sets this change in context with the change results from the period 2006–2012 and finds that the rate of change between the subsequent CORINE land cover maps is continuing to increase. Changes mapped for the period 2012–2018 covered 76,032 ha greater than the change mapped between 2006 and 2012, an increase of 26% of mapped change. The area of changes mapped covered an area equivalent to 1.16% of the total land area of the UK. The number of different types of changes also continue to diversify; however, the dominance of rotational forestry is consistent with the previous map. The process of urban land take has been highlighted in the results between 2012 and 2018 and is a trend identified in previous iterations of the CLC inventories. The largest gain is in industrial or commercial units (an increase of 14.4%). This growth is mainly attributed to renewable energy infrastructure. As well as the descriptive analysis, the results have been analysed to identify the likely pressures being experienced on the land in the UK. Although the CLC mapping approach is consistent, there have been improvements to the input EO data used to map the changes. For 2018, the Copernicus Sentinel-2 system offered a consistent and reliable image source for the first time. This increased the spatial resolution of the source datasets to 10 m, allowing for more accurate identification of small features and those with fine spatial textures such as suburban, road networks and windfarms. We also look forward to the development of CLC+, the new generation of CORINE land mapping, and the improvements it could make.
Hydromorphological Assessment as the Basis for Ecosystem Restoration in the Nanxi River Basin (China)
Authors: Müller Helene , Hörbinger Stephan , Franta Fabian , Mendes Ana , Li Jianhua , Cao Ping , Baoligao Baiyin , Xu Fengran , Rauch Hans Peter
Published: January 2022

Hydromorphology is a major component of riverine ecosystems. Therefore, proper assessments of the status quo, as well as the detection of pressures in river basins, are of high relevance. Process-based morphological methods have been developed, relying on a broad data basis and resulting in suitable instruments, such as the Morphological Quality Index (MQI). In this study, the hydromorphological status of the Nanxi river system in Eastern China was assessed by an adapted application of the MQI. Adaptations and amendments in the methodical approach were developed in cycles and carried out to transfer the well-approved method for European river systems to another geographical setting. The strengths of the tested approach are the few data requirements, the applicability for modified river basins, and the decoupling of historical information. The assessment of 161 river kilometers resulted in a hydromorphological status quo with the focus being a relative comparison of different sections ranging from “moderate” to “bad”, with an average classification of a “poor” state. On the one hand, the results build the basis for future restoration and river management planning, specifically, and on the other hand, they create a foundation for the development of an assessment method fitted for modified river systems conditions.
Case Report of Cerebral Sinus Thrombosis Related to Immune Thrombotic Thrombocytopenia Following Administration of ChAdOx1 nCoV-19 for Vaccination against COVID-19
Authors: Szypowski Wojciech , Dębiec Aleksander , Świstak Jarosław , Nowocień Maciej , Rzepecki Piotr , Możański Marcin , Staszewski Jacek , Stępień Adam
Published: January 2022

Vaccine-induced immune thrombotic thrombocytopenia (VITT) with cerebral venous sinus thrombosis (CVST) has been recently reported after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We present a case of a patient with fulminant CVST and thrombocytopenia after receiving the ChAdOx1 nCoV-19 vaccine. Although the patient received immediate anticoagulant and intravenous immune globulin treatment, he died within 24 h after hospital admission. VITT and CVST are rare conditions; however, the course may be fatal. Therefore, clinicians should be familiarized with the clinical and laboratory features of VITT.
Protection against Osteoarthritis Symptoms by Aerobic Exercise with a High-Protein Diet by Reducing Inflammation in a Testosterone-Deficient Animal Model
Authors: Park Sunmin , Kang Suna , Kim Da Sol , Zhang Ting
Published: January 2022

A testosterone deficiency potentially increases osteoarthritis (OA) symptoms, and dietary protein and exercise affect them. However, their efficacy and their interactions are still unclear. We hypothesized that a high-protein diet (HPD) and regular exercise modulated OA symptoms in testosterone-deficient rats, and it was examined in bilateral orchidectomized (ORX) and monoiodoacetate (MIA)-injected rats. The ORX rats were given a 30 energy percent (En%) protein (HPD) or 17.5 En% protein (CD). Both groups had 39 En% fat in the diet. Non-ORX-CD rats (sham-operation of ORX) were given the CD and no exercise (normal control). After an eight-week intervention, all rats had an injection of MIA into the left knee, and the treatments were continued for an additional four weeks. The non-ORX-CD rats showed a significant increase in body weight compared to the ORX rats, but the ORX rats had elevated fat mass. ORX exacerbated the glucose tolerance by lowering the serum insulin concentrations and increasing insulin resistance. ORX exacerbated the OA symptoms more than the non-ORX-CD. The HPD and exercise improved bone mineral density and glucose metabolism without changing serum testosterone concentrations, while only exercise increased the lean body mass and decreased fat mass, lipid peroxide, and inflammation. Exercise, but not HPD, reduced the OA symptoms, the weight distribution in the left leg, and running velocity and provided better relief than the non-ORX-CD rats. Exercise with HPD improved the histology of the knee joint in the left leg. Exercise reduced lipid peroxide contents and TNF-α and IL-1β mRNA expression in the articular cartilage, while exercise with HPD decreased MMP-3 and MMP-13 mRNA expression as much as in the non-ORX-CD group. In conclusion, moderate aerobic exercise with HPD alleviated OA symptoms and articular cartilage degradation in a similar way in the non-ORX rats with OA by alleviating inflammation and oxidative stress.
A Semantic Annotation Pipeline towards the Generation of Knowledge Graphs in Tribology
Authors: Kügler Patricia , Marian Max , Dorsch Rene , Schleich Benjamin , Wartzack Sandro
Published: January 2022

Within the domain of tribology, enterprises and research institutions are constantly working on new concepts, materials, lubricants, or surface technologies for a wide range of applications. This is also reflected in the continuously growing number of publications, which in turn serve as guidance and benchmark for researchers and developers. Due to the lack of suited data and knowledge bases, knowledge acquisition and aggregation is still a manual process involving the time-consuming review of literature. Therefore, semantic annotation and natural language processing (NLP) techniques can decrease this manual effort by providing a semi-automatic support in knowledge acquisition. The generation of knowledge graphs as a structured information format from textual sources promises improved reuse and retrieval of information acquired from scientific literature. Motivated by this, the contribution introduces a novel semantic annotation pipeline for generating knowledge in the domain of tribology. The pipeline is built on Bidirectional Encoder Representations from Transformers (BERT)—a state-of-the-art language model—and involves classic NLP tasks like information extraction, named entity recognition and question answering. Within this contribution, the three modules of the pipeline for document extraction, annotation, and analysis are introduced. Based on a comparison with a manual annotation of publications on tribological model testing, satisfactory performance is verified.