bluuebunny/crossref_metadata_2025 huggingface dataset:
The Electric Field of the Undisturbed Atmosphere in the South of Western Siberia: A Case Study on Tomsk
Authors: Pustovalov Konstantin , Nagorskiy Petr , Oglezneva Mariya , Smirnov Sergei
Published: April 2022

Currently, many researchers have an interest in the investigation of the electric field in the fair-weather electric environment along with its diurnal and seasonal variations across all regions of the world. However, a similar study in the southern part of Western Siberia has not yet been carried out. In this regard, the paper aims to estimate the mean values of the electric field and their variations in this area using the example of Tomsk. The time series of one-minute average potential gradient values as well as other quantities obtained from the geophysical observatory of the Institute of Monitoring of Climatic and Ecological Systems of the Siberian Branch of the Russian Academy of Sciences (IMCES SB RAS, Tomsk, Russia) from 2006 to 2020 is used in this study. The mean annual value of the potential gradient in Tomsk is 282 V/m and usually varies from 161 to 372 V/m. The diurnal variations in potential gradient per year on average are characterized by oscillations of the continental type with a double maximum and minimum. The main minimum of diurnal variations is 7 h and the main maximum is 21 h of local time (00 and 14 UTC, respectively). According to the annual mode, the maximum potential gradient is observed in February, and the minimum is recorded in June.
Assessing the Impact of Cumulus Parameterization Schemes on Simulated Summer Wind Speed over Mainland China
Authors: Liu Si-Jie , Wang Ming , Yi Xiang , Shao Shuai-Bing , Zheng Yi-Qun , Zeng Xin-Min
Published: April 2022

Wind speed is an important meteorological parameter, whose simulation is influenced by various physical process parameterizations. However, the impact of cumulus parameterization schemes (CPSs) on wind speed simulation at the climate scale has not been sufficiently investigated in previous studies. Using the Advanced Research version of the Weather Research and Forecasting model (ARWv3) and hydrostatic wind speed change equation, we assessed the effects of four CPSs on a 10 m wind speed simulation over mainland China in the summer of 2003. In general, different CPSs can reproduce the wind speed distribution. Meanwhile, the sensitivity of wind speed simulation to CPSs was found to be the highest in East and southern China, followed by the Tibetan Plateau, and then Northwest China. We found that the main physical processes influencing wind speed (i.e., the pressure gradient (PRE), diffusion (DFN), and convection (CON) terms) vary greatly with sub-regions. CPSs mainly affect the secondary CON that regulates the balance between the dominant terms PRE and DFN, and also has a significant effect on PRE. For example, for CON, the difference index (DIF) between the Kain–Fritsch (KF) and previous KF (pKF) CPSs is larger than 20%, corresponding to a PRE DIF of about 14%. The term of local wind speed change (Vt) is significantly more sensitive to the CPSs than the other terms with a DIF of 283% over the Tibetan Plateau, suggesting high CPS sensitivity of the simulated wind speed. In addition, we explained the causes of the CPS-induced sensitivities. This work helps understand the Weather Research and Forecasting model (WRF) performance and emphasizes the importance of the CPS choice in simulating/forecasting wind speed.
Reliability and Validity of the Athletic Shoulder (ASH) Test Performed Using Portable Isometric-Based Strength Training Device
Authors: Królikowska Aleksandra , Mika Anna , Plaskota Bartosz , Daszkiewicz Maciej , Kentel Monika , Kołcz Anna , Kentel Maciej , Prill Robert , Diakowska Dorota , Reichert Paweł , Stolarczyk Artur , Oleksy Łukasz
Published: April 2022

The Athletic Shoulder (ASH) test was introduced as a tool for quantifying the ability to produce and transfer force across the shoulder girdle. Whether using the portable isometric-based strength training device Active5™ is a reliable alternative to a gold standard force plate for ASH testing purposes remains unknown; therefore, the present study determined the reliability and validity of Active5™ usage in the ASH test compared to force plates. Fifty-one healthy participants performed the ASH test using Active5™ and K-Force plates in three separate sessions. The maximal force was measured bilaterally in a prone position at three shoulder abduction angles, precisely at 180°, 135°, and 90°. The first rater carried out the first and third sessions, spaced at a one-week interval. A second rater performed the second session. The reliability was assessed using the intraclass correlation coefficient (ICC). The linear Pearson’s correlation coefficient (r) calculation was used to determine the relationship between ASH test results using the two devices. The ICC = 0.77–0.99 result indicated good to excellent reliability for Active5™ usage. A high to a very high correlation between the two devices at 180° and 90° was noted (r = 0.75–0.95). This data supports the isometric-based strength training device Active5™ as a reliable and valid tool for ASH test performance.
Work/Life Relationships and Communication Ethics: An Exploratory Examination
Authors: Fritz Janie M. Harden
Published: April 2022

Workplace relationships that transcend formal role boundaries offer benefits and challenges to organizations and relational participants. Communicative processes that form and maintain these relationships can be examined from a communication ethics perspective focused on the outcomes emerging from these relationships that define particular goods for personal and organizational life. The blended nature of these relationships makes them host to potentially competing goods tied to public and private concerns. Considering the connection of virtue approaches to communication ethics in organizational settings to the turn to positive approaches to communication and organizational theory reveals avenues for ethical reflection and action in these increasingly important relational forms.
Confirmatory Factor Analysis of Performance Measurement Indicators Determining the Uptake of CPS for Facilities Management
Authors: Ikuabe Matthew , Aigbavboa Clinton , Anumba Chimay , Oke Ayodeji , Aghimien Lerato
Published: April 2022

With the use of cyber-physical systems (CPS) advanced computational capabilities, the delivery of facilities management (FM) mandates are efficiently and effectively conducted. Since performance measurement is an important yardstick in ascertaining the outcome of FM approaches, this study assesses the performance measurement indicators that influence the uptake of CPS for FM functions. Using a structured questionnaire, data were collected from built environment professionals in the Gauteng province of South Africa. Data collected was analysed using a five-stage process which includes: data reliability and validity, descriptive statistics, establishing a difference in groups’ opinion, principal component analysis, and model testing and fit statistics for confirmatory factor analysis. Results from the study indicate that three significant performance indicators are influential in determining the uptake of CPS for FM, which are operations efficiency, facility adaptation, and client’s satisfaction. The study contributes immensely to the body of knowledge. It unveils the significant performance measurement indicators that would help organisations, facilities managers, and policymakers guide their decisions hinged on the espousal of innovative technologies. Furthermore, the study serves as a solid theoretical base for further studies showcasing a roadmap for digitalisation for FM functions by unravelling the significant performance measurement indicators.
Quality Analysis on Indoor Thermal Comfort and Energy-Saving Improvement Strategy of Slate Dwellings, China
Authors: Xu Juan , Yang Wenting , Lu Ziliang , Wu Yan , Hou Chaoping , Liu Dan
Published: April 2022

Slate dwellings are known as the “living fossil of primitive dwellings” in China. Energy-saving strategies are crucial to slate dwellings for sustainability as well as maintaining thermal comfort. In this research, a subjective satisfaction analysis on the indoor thermal environment in Daziliang village, China, was conducted. It was found that neutral temperature is 20.92 °C in summer, 8.92 °C in winter, and the actual operating temperature in winter is too low to meet the 80% acceptable range. Therefore, a series of improvement strategies in winter were proposed. The results showed that adding external thermal insulation material—expanded polystyrene board with a thickness of 80 mm on the roof and outside walls—and sunspace depth of 1.5 m are better in terms of energy-saving effects. In addition, the slate dwelling’s daily energy-saving rate of the heating day is 44.26% lower than the original state through these strategies. The air temperature of Bedroom D in winter non-heating days increases by 3.82 °C after improvement and the mean radiant temperature increased by 2.54 °C. Our approach puts forward specific energy-saving improvement measures and provides feasible suggestions for the protection and development of slate dwellings in this area.
Monitoring Approaches for New-Generation Energy Performance Certificates in Residential Buildings
Authors: Salvalai Graziano , Sesana Marta Maria
Published: April 2022

In 2002, the Energy Performance of Building Directive (EPBD) introduced energy certification schemes to classify and compare building performances to support reaching energy efficiency targets by informing the different actors of the building sectors. However, since its implementation, the Energy Performance Certifications (EPCs) remained unexploited with limited impact on the energy savings targets. In this context, the EPC RECAST project aims at studying a new generation of EPCs with a focus on the residential sector. More in detail, the paper presents and frames a monitoring approach based on low-cost and non-invasive technology for real data collection in existing residential apartments/houses. The method is based on different levels of monitoring selected according to the typology of the building (e.g., detached house, apartment), services (e.g., centralized or local energy generation), and energy vectors (e.g., natural gas or electricity). Three different levels have been identified (named as: basic, medium, and advanced) and for each one, different plug and play monitoring sensor kits have been selected. Six representative pilot buildings have been identified and selected to verify the approach in general and, in particular, the sensors’ applicability and communication, the data reliability, and the monitoring platform. The presented work highlights, on the one hand, the general feasibility of the proposed monitoring approach; on the other, it highlights the difficulty of fully standardizing the sensors kits considering that each building/apartment has specific characteristics and constraints that have to be carefully analyzed. The use of the ultrasonic flow meters represents a good technical option for reducing the cost and the impact on the existing plant system; however, their installation must be verified considering that the logger needs to be powered and the sensors calibrated for collecting reliable data.
Endometrial Cancer Management in Young Women
Authors: Markowska Anna , Chudecka-Głaz Anita , Pityński Kazimierz , Baranowski Włodzimierz , Markowska Janina , Sawicki Włodzimierz
Published: April 2022

Endometrial cancer (EC) rarely develops in young women. Most cases are associated with known risk factors: BMI > 30, history of Polycystic Ovary Syndrome (PCOs), and race differentiation. The molecular EC classification based on The Cancer Genome Atlas Research Network divides these heterogeneous cancers into four types: Polymerase Epsilon Mutation (POLE), Microsatellite Instability (MSI), Copy Number Low (CNL), and Copy Number High (CNH). This division was introduced to allow for early assessment of neoplastic changes and clinical management, including targeted therapies. The basic technique for imaging endometrium changes is transvaginal sonography. Hysteroscopy is the standard for obtaining endometrial material for histological evaluation. The MRI result permits assessment of the extent of EC cancer infiltration. In young women who want to preserve fertility, apart from surgery, conservative management is often implemented after strict selection based on clinical and pathological data. This pharmacological treatment involves the administration of progestogens MPA (medroxyprogesterone acetate) and MA (megestrol acetate). The use of metformin may increase the effectiveness of such treatment. An alternative option is to apply progestogens locally—via the levonorgestrel-releasing intrauterine device. In addition to pharmacological treatment, hysteroscopic resection may be used—part of the uterine muscle adjacent to the pathologically changed endometrium may also undergo resection. An alternative is the administration of estrogen receptor modulators (e.g., SERMs) or aromatase inhibitors, or GnRH agonists.
Pancreaticoduodenectomy Is the Best Surgical Procedure for Zollinger–Ellison Syndrome Associated with Multiple Endocrine Neoplasia Type 1
Authors: Kong Weihua , Albers Max Benjamin , Manoharan Jerena , Goebel Joachim Nils , Kann Peter Herbert , Jesinghaus Moritz , Bartsch Detlef Klaus
Published: April 2022

Aim: The aim of this research was to evaluate the long-term outcome of pancreaticoduodenectomy (PD) versus other duodenopancreatic resections (non-PD) for the surgical treatment of the Zollinger–Ellison syndrome (ZES) in patients with multiple endocrine neoplasia type 1 (MEN1). Methods: Prospectively recorded patients with biochemically confirmed MEN1-ZES who underwent duodenopancreatic surgery were retrospectively analyzed in terms of clinical characteristics, complications, cure rate, and long-term morbidity, including quality of life assessment (EORTC QLQ-C30). Results: 35 patients (16 female, 19 male) with MEN1-ZES due to duodenopancreatic gastrinomas with a median age of 42 (range 30–74) years were included. At the time of diagnosis, 28 (80%) gastrinomas were malignant, but distant metastases were only present in one (3%) patient. Eleven patients (31.4%) underwent pancreatoduodenectomy (PD) as the initial procedure, whereas 24 patients underwent non-PD resections involving duodenotomy with gastrinoma excision, enucleation of the pNEN from the head of the pancreas, and peripancreatic lymphadenectomy, either with or without distal pancreatectomy (i.e., either Thompson procedure, n = 12, or DUODX, n = 12). There was no significant difference in perioperative morbidity and mortality between the two groups (p ≥ 0.05). One (9%) patient of the PD group required reoperation for recurrent or metastatic ZES compared to eight (22.8%) patients of the non-PD resection groups. After a median follow-up time of 134 months (range 6–480) nine of 11 (82%) patients in the PD group, two of 12 (16%) patients in the Thompson procedure group, and three of 12 (25%) patients in the DUODX group had normal serum gastrin levels. In addition, the global health QoLScore was better in the PD group (76.9) compared to the Thompson procedure (57.4) and DUODX (59.5) groups. Conclusions: Initial PD seems to be the superior surgical procedure for MEN1-ZES, resulting in a long-term cure rate of about 80%, fewer duodenopancreatic reoperations, and an acceptable quality of life.
Acquired Mechanisms of Resistance to Osimertinib—The Next Challenge
Authors: Ríos-Hoyo Alejandro , Moliner Laura , Arriola Edurne
Published: April 2022

EGFR-mutated tumors represent a significant percentage of non-small cell lung cancer. Despite the increasing use of osimertinib, a treatment that has demonstrated an outstanding clinical benefit with a tolerable toxicity profile, EGFR tumors eventually acquire mechanisms of resistance. In the last years, multiple mechanisms of resistance have been identified; however, after progressing on osimertinib, treatment options remain bleak. In this review, we cover the most frequent alterations and potential therapeutic strategies to overcome them.
Metal Embedded Porous Carbon for Efficient CO2 Cycloaddition under Mild Conditions
Authors: Qi Chen , Chaemchuen Somboon , Liu Meng , Wang Jichao , Zhuiykov Serge , Verpoort Francis
Published: April 2022

Nitrogen-doped porous carbon material was generated via thermal pyrolysis of zeolitic imidazole frameworks (ZIFs). The structure of the ZIF templates was tuned, so that the obtained product was an N-doped porous carbon-containing encapsulated metal nanoparticle. The hierarchical structural and unique properties of pyrolyzed materials are involved in further application, including catalysis. The as-synthesized porous carbon materials were applied as a catalyst for CO2 fixation on cyclic carbonates under near ambient pressure without solvent and co-catalyst. The zinc dispersion in highly porous carbon material, deriving from ZIF-8, exhibited a superior catalytic performance among the synthesized materials. The acid sites (Zn species) and the incorporated basic sites (N-species) present in the porous carbon material are essential for a high affinity for gas adsorption and CO2 conversion. Additionally, the catalyst was found to be very robust and stable during recycling studies as the catalytic performance remained high for seven cycles.
Hybrid Catalysts from Copper Biosorbing Bacterial Strains and Their Recycling for Catalytic Application in the Asymmetric Addition Reaction of B2(pin)2 on α,β-Unsaturated Chalcones
Authors: Gandolfi Raffaella , Facchetti Giorgio , Cavalca Lucia , Mazzini Stefania , Colombo Milena , Coffetti Giulia , Borgonovo Gigliola , Scaglioni Leonardo , Zecchin Sarah , Rimoldi Isabella
Published: April 2022

The recycling of heavy metal contaminants from wastewater as a source of valuable products perfectly fits with the principles of a Circular Economy system in view of restoring pollutants back into the system endowed with new social and economic benefits. Heavy metals are often present in such a low concentration that it makes the removal efficiency difficult to realize through the conventional physicochemical methods with high selectivity. Biosorption, conversely, by EPSs (extracellular polymeric substances) produced by several bacterial cells’ strains, is gaining a great deal of attention as an economic, efficient and sustainable depolluting process of wastewater from metal cations such as copper. Metal coordination to EPS components was thus deeply investigated by 1H NMR titration experiments. The 1,10–Phenanthroline–copper complex was exploited for quantifying the ability of different strains to sequester copper by a practical UV-Vis spectrophotometric method. The obtained data distinguished Serratia plymuthica strain SC5II as the bacterial strain displaying copper-adsorbing properties higher than any other, with Stenotrophomonas sp. strain 13a resulting in the worst one. Different analytical techniques, i.e., Dynamic Light Scattering (DLS), FT-IR analysis and SEM spectroscopy were thus employed to rationalize these results. Finally, the obtained copper chelates were successfully employed as hybrid catalysts in the asymmetric boron addition to α,β-unsaturated chalcones for the synthesis of valuable pharmaceutical intermediates, thus placing waste management in a new circular perspective.
Protective Effect of Follicle-Stimulating Hormone on DNA Damage of Chicken Follicular Granulosa Cells by Inhibiting CHK2/p53
Authors: Zhou Shuo , Zhao An , Wu Yangyang , Bao Tingting , Mi Yuling , Zhang Caiqiao
Published: April 2022

The increase in follicular atresia and the decrease in the fecundity of laying hens occur with the aging process. Therefore, the key measure for maintaining high laying performance is to alleviate follicular atresia in the aging poultry. Follicle-stimulating hormone (FSH), as an important pituitary hormone to promote follicle development and maturation, plays an important role in preventing reproductive aging in diverse animals. In this study, the physiological state of the prehierarchical small white follicles (SWFs) and atretic SWFs (ASWFs) were compared, followed by an exploration of the possible capacity of FSH to delay ASWFs’ progression in the hens. The results showed that the DNA damage within follicles increased with aging, along with Golgi complex disintegration, cell cycle arrest, increased apoptosis and autophagy in the ASWFs. Subsequently, the ACNU-induced follicular atresia model was established to evaluate the enhancing capacity of FSH on increasing cell proliferation and attenuating apoptosis in ASWFs. FSH inhibited DNA damage and promoted DNA repair by regulating the CHK2/p53 pathway. Furthermore, FSH inhibited CHK2/p53, thus, suppressing the disintegration of the Golgi complex, cell cycle arrest, and increased autophagy in the atretic follicles. Moreover, these effects from FSH treatment in ACNU-induced granulosa cells were similar to the treatment by a DNA repair agent AV-153. These results indicate that FSH protects aging-resulted DNA damage in granulosa cells by inhibiting CHK2/p53 in chicken prehierarchical follicles.
Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners
Authors: Doretto Lucas B. , Butzge Arno J. , Nakajima Rafael T. , Martinez Emanuel R. M. , de Souza Beatriz Marques , Rodrigues Maira da Silva , Rosa Ivana F. , Ricci Juliana M. B. , Tovo-Neto Aldo , Costa Daniel F. , Malafaia Guilherme , Shao Changwei , Nóbrega Rafael H.
Published: April 2022

Glial cell line-derived neurotrophic factor (GDNF) and its receptor (GDNF Family Receptor α1-GFRα1) are well known to mediate spermatogonial stem cell (SSC) proliferation and survival in mammalian testes. In nonmammalian species, Gdnf and Gfrα1 orthologs have been found but their functions remain poorly investigated in the testes. Considering this background, this study aimed to understand the roles of the Gdnf-Gfrα1 signaling pathway in zebrafish testes by combining in vivo, in silico and ex vivo approaches. Our analysis showed that zebrafish exhibit two paralogs for Gndf (gdnfa and gdnfb) and its receptor, Gfrα1 (gfrα1a and gfrα1b), in accordance with a teleost-specific third round of whole genome duplication. Expression analysis further revealed that both ligands and receptors were expressed in zebrafish adult testes. Subsequently, we demonstrated that gdnfa is expressed in the germ cells, while Gfrα1a/Gfrα1b was detected in early spermatogonia (mainly in types Aund and Adiff) and Sertoli cells. Functional ex vivo analysis showed that Gdnf promoted the creation of new available niches by stimulating the proliferation of both type Aund spermatogonia and their surrounding Sertoli cells but without changing pou5f3 mRNA levels. Strikingly, Gdnf also inhibited late spermatogonial differentiation, as shown by the decrease in type B spermatogonia and down-regulation of dazl in a co-treatment with Fsh. Altogether, our data revealed that a germ cell-derived factor is involved in maintaining germ cell stemness through the creation of new available niches, supporting the development of spermatogonial cysts and inhibiting late spermatogonial differentiation in autocrine- and paracrine-dependent manners.
The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers
Authors: Molnar Richard , Szabo Laszlo , Tomesz Andras , Deutsch Arpad , Darago Richard , Raposa Bence L. , Ghodratollah Nowrasteh , Varjas Timea , Nemeth Balazs , Orsos Zsuzsanna , Pozsgai Eva , Szentpeteri Jozsef L. , Budan Ferenc , Kiss Istvan
Published: April 2022

Polyphenols are capable of decreasing cancer risk. We examined the chemopreventive effects of a green tea (Camellia sinensis) extract, polyphenol extract (a mixture of blackberry (Rubus fruticosus), blackcurrants (Ribes nigrum), and added resveratrol phytoalexin), Chinese bayberry (Myrica rubra) extract, and a coffee (Coffea arabica) extract on 7,12-dimethylbenz[a]anthracene (DMBA) carcinogen-increased miR-134, miR-132, miR-124-1, miR-9-3, and mTOR gene expressions in the liver, spleen, and kidneys of CBA/Ca mice. The elevation was quenched significantly in the organs, except for miR-132 in the liver of the Chinese bayberry extract-consuming group, and miR-132 in the kidneys of the polyphenol-fed group. In the coffee extract-consuming group, only miR-9-3 and mTOR decreased significantly in the liver; also, miR-134 decreased significantly in the spleen, and, additionally, miR-124-1 decreased significantly in the kidney. Our results are supported by literature data, particularly the DMBA generated ROS-induced inflammatory and proliferative signal transducers, such as TNF, IL1, IL6, and NF-κB; as well as oncogenes, namely RAS and MYC. The examined chemopreventive agents, besides the obvious antioxidant and anti-inflammatory effects, mainly blocked the mentioned DMBA-activated factors and the mitogen-activated protein kinase (MAPK) as well, and, at the same time, induced PTEN as well as SIRT tumor suppressor genes.
Emerging Evidence of Noncoding RNAs in Bleb Scarring after Glaucoma Filtration Surgery
Authors: Yu Sabrina , Tam Alex L. C. , Campbell Robert , Renwick Neil
Published: April 2022

Purpose: To conduct a narrative review of research articles on the potential anti- and pro-fibrotic mechanisms of noncoding RNAs following glaucoma filtration surgery. Methods: Keyword searches of PubMed, and Medline databases were conducted for articles discussing post-glaucoma filtration surgeries and noncoding RNA. Additional manual searches of reference lists of primary articles were performed. Results: Fifteen primary research articles were identified. Four of the included papers used microarrays and qRT-PCR to identify up- or down-regulated microRNA (miRNA, miR) profiles and direct further study, with the remainder focusing on miRNAs or long noncoding RNAs (lncRNAs) based on previous work in other organs or disease processes. The results of the reviewed papers identified miR-26a, -29b, -139, -155, and -200a as having anti-fibrotic effects. In contrast, miRs-200b and -216b may play pro-fibrotic roles in filtration surgery fibrosis. lncRNAs including H19, NR003923, and 00028 have demonstrated pro-fibrotic effects. Conclusions: Noncoding RNAs including miRNAs and lncRNAs are emerging and promising therapeutic targets in the prevention of post-glaucoma filtration surgery fibrosis.
Wasteless Synthesis and Properties of Highly Dispersed MgAl2O4 Based on Product of Thermal Activation of Gibbsite
Authors: Zhuzhgov Aleksey V. , Kruglyakov Vasily Y. , Glazneva Tatyana S. , Suprun Evgeny A. , Isupova Lyubov A.
Published: April 2022

The study showed that the interaction of the product of centrifugal thermal activation of gibbsite with an aqueous solution of magnesium nitrate at a cationic ratio Mg:Al = 1:2 leads to the formation of mixed double hydroxides both under hydrothermal treatment at 150 °C and at room temperature. The subsequent thermal treatment at 550 °C of the product of mild interaction leads to ~90% alumina-magnesia spinel and ~10% MgO, while the treatment of the hydrothermal interaction product leads to ~100% spinel with the stoichiometric composition MgAl2O4. The obtained spinel samples possess a high specific surface area (above 100 m2/g) and a hierarchical pore structure formed by the micron-level particles of different sizes (1–2 and 10–20 μm) consisting of ~70 nm crystallites with ~3 nm pores; the samples differ mostly in the total volume and quantitative ratio of the pores. The samples have Lewis acid sites of moderate strength on the surface, the amount of which is much lower to how it is when compared with a sample prepared by precipitation in that they also differ by quantity from each other as well (503 μmol/g for stoichiometric spinel and 304 μmol/g for sample with admixture of MgO). As the calcination temperature is raised to 850 °C, the acidity decreases—only weak Lewis acid sites are observed, the amount of which is also higher for stoichiometric spinel (161 and 39 μmol/g, respectively). The method proposed for the synthesis of alumina-magnesia systems provides a high dispersion and a much lower surface acidity for the oxides; in addition, it minimizes or completely excludes wash water, in distinction to the precipitation method.
Usefulness and Limits of Tractography for Surgery in the Precentral Gyrus—A Case Report
Authors: Wende Tim , Wilhelmy Florian , Kasper Johannes , Prasse Gordian , Franke Christian , Arlt Felix , Frydrychowicz Clara , Meixensberger Jürgen , Nestler Ulf
Published: April 2022

The resection of tumors within the primary motor cortex is a constant challenge. Although tractography may help in preoperative planning, it has limited application. While it can give valuable information on subcortical fibers, it is less accurate in the cortical layer of the brain. A 38-year-old patient presented with paresis of the right hand and focal epileptic seizures due to a tumor in the left precentral gyrus. Transcranial magnetic stimulation was not applicable due to seizures, so microsurgical resection was performed with preoperative tractography and intraoperative direct electrical stimulation. A histopathological assessment revealed a diagnosis of glioblastoma. Postoperative magnetic resonance imaging (MRI) showed complete resection. The paresis dissolved completely during follow-up. Surgery within the precentral gyrus is of high risk and requires multimodal functional planning. If interpreted with vigilance and consciousness of the underlying physical premises, tractography can provide helpful information within its limitations, which is especially subcortically. However, it may also help in the identification of functional cortex columns of the brain in the presence of a tumor.
Preparations and Applications of MXene–Metal Composites: A Review
Authors: Khan Maaz Ullah , Du LiJing , Fu Shuai , Wan Detian , Bao Yiwang , Feng Qingguo , Grasso Salvatore , Hu Chunfeng
Published: April 2022

MXene, an advanced family of 2D ceramic material resembling graphene, has had a considerable impact on the field of research because of its unique physiochemical properties. MXene has been synthesized by the selective etching of MAX via different techniques. However, with the passage of time, due to the need for further progress and improvement in MXene materials, ideas have turned toward composite fabrication, which has aided boosting the MXene composites regarding their properties and applications in various areas. Many review papers are published on MXene and their composites with polymer, carbon nanotube, graphene, other carbon, metal oxides and sulfides, etc., except metal composite, and such papers discuss these composites thoroughly. In this review article, we illustrate and explain the development of MXene-based metal composites. Furthermore, we highlight the synthesis techniques utilized for the preparation of MXene composites with metal. We briefly discuss the enhancement of properties of the composites and a wide range of applications as an electrode substance for energy storage devices, electrochemical cells, supercapacitors, and catalytic and anti-corrosive performance. Major obstacles in MXene and metal composite are mentioned and provide future recommendations. Together, they can overcome problems and enable MXene and composites on commercial-scale production.
Design and Synthesis of Multipotent Antioxidants for Functionalization of Iron Oxide Nanoparticles
Authors: Shah Syed Tawab , Chowdhury Zaira Zaman , Johan Mohd Rafie , Badruddin Irfan Anjum , Alrobei Hussein , Kamangar Sarfaraz
Published: April 2022

Multipotent antioxidants (MPAO) were synthesized and characterized by FTIR, NMR. The functionalized nanoparticles (IONP@AO) were characterized by FTIR, XRD, Raman, HRTEM, FESEM, VSM, and EDX. IONP@AO1 and IONP@AO2 have average particles size of 10 nm and 11 nm, respectively. The functionalized IONP@AO has a superparamagnetic nature, with saturation magnetization of 45 emu·g−1. Structure-based virtual screening of the designed MPAO was performed by PASS analysis and ADMET studies to discover and predict the molecule’s potential bioactivities and safety profile before the synthesis procedure. The half-maximal inhibitory concentration (IC50) of DPPH analysis results showed a four-fold decrease in radical scavenging by IONP@AO compared to IONP. In addition to antioxidant activity, IONP@AO showed suitable antimicrobial activities when tested on various bacterial and fungal strains. The advantage of the developed nanoantioxidants is that they have a strong affinity towards biomolecules such as enzymes, proteins, amino acids, and DNA. Thus, synthesized nanoantioxidants can be used to develop biomedicines that can act as antioxidant, antimicrobial, and anticancer agents.
Review of Cr-Free Coatings for the Corrosion Protection of Aluminum Aerospace Alloys
Authors: Peltier Fabienne , Thierry Dominique
Published: April 2022

Aluminum alloys are known to have many advantages (e.g., light weight and low cost) but they are not immune to corrosion. So, it is important to assess their corrosion behavior, in particular under atmospheric conditions. To protect aluminum alloys against corrosion, paints are generally applied onto the materials. Corrosion protection in the aerospace industry consists of a conversion or anodized coating, an inhibited primer, and a top-coat. Chromate conversion coating (CCC) and primers containing chromate pigments have been widely used in the aerospace industry over the last decades. However, new environmental regulations have led to major changes for aluminum corrosion protection. By limiting or prohibiting some chemicals, for instance Cr(VI), the European regulation REACH (Regulation on Registration Evaluation, Authorization and Restriction of Chemicals) has induced major changes to some of the finishing processes of aluminum alloys (e.g., chromate conversion, chromic acid anodizing, and chromate sealing). Interesting results have been obtained while seeking replacements for Cr(VI), for example, with the incorporation of cerium, lithium salt, or nanocontainers loaded with corrosion inhibitors in organic coatings. For several years, hybrid sol–gel coatings able to replace the pre-treatment and primer steps have been under development, showing interesting results. New prospects for the future involve the use of photopolymerization to reduce the energy-intensive heat treatment needed in sol–gel technology. It will also be necessary to test these new technologies in service conditions or in accelerated corrosion tests before being able to conclude on the real effectiveness of these coatings. This review summarizes the recent developments in Cr-free coatings for aluminum alloys. Their advantages and drawbacks are also discussed.
Application of the Hurricane Optimization Algorithm to Estimate Parameters in Single-Phase Transformers Considering Voltage and Current Measures
Authors: Cortés-Caicedo Brandon , Montoya Oscar Danilo , Arias-Londoño Andrés
Published: April 2022

In this research paper, a combinatorial optimization approach is proposed for parameter estimation in single-phase transformers considering voltage and current measurements at the transformer terminals. This problem is represented through a nonlinear programming model (NLP), whose objective is to minimize the root mean square error between the measured voltage and current values and the calculated values from the equivalent model of the single-phase transformer. These values of voltage and current can be determined by applying Kirchhoff’s Laws to the model T of the transformer, where its parameters, series resistance and reactance as well as the magnetization resistance and reactance, i.e., R1, R2′, X1, X2′, Rc y Xm, are provided by the Hurricane Optimization Algorithm (HOA). The numerical results in the 4 kVA, 10 kVA and 15 kVA single-phase test transformers demonstrate the applicability of the proposed method since it allows the reduction of the average error between the measured and calculated electrical variables by 1000% compared to the methods reported in the specialized literature. This ensures that the parameters estimated by the proposed methodology, in each test transformer, are close to the real value with an accuracy error of less than 6%. Additionally, the computation times required by the algorithm to find the optimal solution are less than 1 second, which makes the proposed HOA robust, reliable, and efficient. All simulations were performed in the MATLAB programming environment.
An Electrochemical Investigation of Methanol Oxidation on Thin Films of Nickel Oxide and Its Composites with Zirconium and Yttrium Oxides
Authors: Mahmood Karishma , Mansoor Muhammad Adil , Iqbal Mudassir , Kalam Abul , Iqbal Javed , Jilani Asim , Wageh S.
Published: April 2022

The present work is focused on the fabrication of NiO-ZrO2/FTO and NiO-Y2O3/FTO thin films via a simple dip-coating method. The films are deposited from precursor solutions of Ni(CH3COO)2·2H2O, Zr(CH3COO)4, Y(CH3COO)3·H2O in methanol. The synthesized films, after proper characterization, are employed for electrochemical oxidation of methanol. The analytical techniques such as X-ray diffraction (XRD), Raman, and Infrared (IR) spectroscopy reveal the successful formation of crystalline thin films of mixed metal oxide without any additional impurities. Further, X-ray photoelectron spectroscopy (XPS) results, confirm the composition and oxidation state of all the elements present in thin films. The field emission scanning electron microscopy (FESEM) further aided to identify the uniformity and porous nature of composite thin films while the energy-dispersive X-ray spectroscopy (EDS) confirms the targeted elemental composition of the prepared thin films is in good agreement with precursors. The electrochemical oxidation of methanol results reveals that NiO-Y2O3/FTO and NiO-ZrO2/FTO thin films showed current densities of 6.2 mA/cm2 and 10 mA/cm2 at 0.65 V, respectively, against Ag/AgCl/3M KCl using 0.6 M methanol solution. Furthermore, Chronoamperometric (CA) results show good stability of NiO-ZrO2/FTO and NiO-Y2O3/FTO thin films with observed current decay of 10% and 6.8% of the initial current density, respectively. Moreover, the effect of scan rate and concentration of metals in a catalyst was also investigated. The Electrochemical impedance studies (EIS) further support electrochemical results, where the lower charge transfer resistance (Rct) values are recorded for composite thin films as compared to the pure metal oxide thin films (NiO/FTO, ZrO2/FTO, and Y2O3/FTO).
Cerebral Venous Sinus Thrombosis Associated with Vaccine-Induced Thrombotic Thrombocytopenia—A Narrative Review
Authors: Scutelnic Adrian , Brodard Justine , Kremer Hovinga Johanna A. , Arnold Marcel , Heldner Mirjam R.
Published: April 2022

In March 2021, cerebral venous sinus thrombosis and thrombocytopenia after vaccination with adenovirus-based vaccine against SARS-CoV-2 were first reported. The underlining condition has been termed vaccine-induced immune thrombocytopenia (VITT). Anti-platelet factor 4 antibodies have been proposed as a central component of the pathomechanism. Treatment recommendations entailed immunomodulation with intravenous immunoglobulins, avoidance of heparins and avoidance of platelet transfusions. Although mortality from VITT-associated cerebral venous sinus thrombosis has decreased over time, it remains high. The aim of this narrative review is to describe different aspects of this disease according to the current state of knowledge.
Understanding the Post-Treatment Concerns of Cancer Survivors with Five Common Cancers: Exploring the Alberta Results from the Pan-Canadian Transitions Study
Authors: Link Claire , DeIure Andrea , Watson Linda
Published: April 2022

As the rates of cancer incidence and survival increase in Canada, more patients are living in the post-treatment survivorship phase of their cancer journey. Identifying cancer survivors’ concerns and unmet needs is important so that health care teams can provide relevant information, supports, and resources. Secondary data analysis was carried out on the Alberta patient sample from the 2016 Pan-Canadian Transitions Study survey, designed by the Canadian Partnership Against Cancer. The top concerns for patients treated for five different cancers were examined descriptively and compared. A question about information that patients received post-treatment was also descriptively analyzed. Binary logistic regressions were conducted for each tumour group, using the top three concerns for each group as outcomes and a variety of demographic factors as independent variables. There were 1833 valid respondents in the Alberta sample. Fatigue and anxiety were top concerns for multiple tumour groups. Most patients received more information about treatment side effects than about signs of recurrence and community resources. Within certain tumour groups, younger patients had higher odds of having concerns, particularly anxiety. Awareness of the common and unique concerns experienced by cancer survivors post-treatment enables health care providers to tailor care and resources to help patients manage their symptoms and concerns. These findings address gaps in knowledge around the cancer survivorship phase and may be applicable to cancer programs and primary care providers in Alberta and beyond.
Comparative Analysis of the Polymorphism of the Casein Genes in Camels Bred in Kazakhstan
Authors: Amandykova Makpal , Dossybayev Kairat , Mussayeva Aizhan , Bekmanov Bakytzhan , Saitou Naruya
Published: April 2022

Caseins play an important role in determining the technological properties and quantitative characteristics of camel milk. To date, only a few studies on the genetic polymorphism of casein genes have been reported in the camel populations of Kazakhstan. Therefore, this work aimed to identify the genetic polymorphism level of casein genes among camel populations of the Almaty region of Kazakhstan. The PCR-RFLP method was used for this purpose and the following genotypes were revealed as a result: CSN3 gene—CC, CT, TT, where the T allele predominated in all populations, with a frequency of 0.60; CSN2 gene—AA, AG, GG, with the predomination of A allele (0.64); and CSN1S1 gene—GG and GT, with the predomination of G allele (0.94). Statistical analysis was carried out using the POPGENE and GenAlEx software. The χ2 values were equal to 12.1 (CSN3), 8.6 (CSN2), and 14.5 (CSN1S1). As a result, three out of 53 animals were designated as the “core” of the population—animals with the desired genotypes: CC genotype for the CSN3 gene and AA genotype for the CSN2 gene. Such animals can be selected for further use with an increase in the number of livestock with high productivity rates.
Using Culture-Dependent and Molecular Techniques to Identify Endophytic Fungi Associated with Tea Leaves (Camellia spp.) in Yunnan Province, China
Authors: Tibpromma Saowaluck , Karunarathna Samantha C. , Bhat Jayarama D. , Suwannarach Nakarin , Stephenson Steven L. , Elgorban Abdallah M. , Al-Rejaie Salim , Xu Jianchu , Mortimer Peter E.
Published: April 2022

The association of endophytic fungi with the host plant is called a symbiotic relationship. Studies of the endophytic fungi from tea have been reported in numerous documents, but researchers still largely focus on tea endophytic fungi as they have ability to produce bioactive compounds which have numerous applications. The present work characterizes the fungal endophytic communities associated with healthy tea leaves in Yunnan Province, China. A total of 287 fungal strains were isolated from healthy leaf tissues of tea plants using a culture-dependent approach. Based on nuclear ribosomal DNA internal transcribed spacer (ITS) sequence analyses taken from the fungal cultures, strains were classified into 28 fungal genera with high similarity matches to known sequences in GenBank. The majority of genera (98.25%) belong to the phylum Ascomycota and most of the dominating fungal endophytes are from the genera Colletotrichum and Clonostachys.
Evaluating the Influence of Mood and Stress on Glycemic Variability in People with T1DM Using Glucose Monitoring Sensors and Pools
Authors: Velasco Jose Manuel , Botella-Serrano Marta , Sánchez-Sánchez Almudena , Aramendi Aranzazu , Martínez Remedios , Maqueda Esther , Garnica Oscar , Contador Sergio , Lanchares Juan , Hidalgo José Ignacio
Published: April 2022

Objective: Assess in a sample of people with type 1 diabetes mellitus whether mood and stress influence blood glucose levels and variability. Material and Methods: Continuous glucose monitoring was performed on 10 patients with type 1 diabetes mellitus, where interstitial glucose values were recorded every 15 min. A daily survey was conducted through Google Forms, collecting information on mood and stress. The day was divided into six slots of 4-h each, asking the patient to assess each slot in relation to mood (sad, normal or happy) and stress (calm, normal or nervous). Different measures of glycemic control (arithmetic mean and percentage of time below/above the target range) and variability (standard deviation, percentage coefficient of variation, mean amplitude of glycemic excursions and mean of daily differences) were calculated to relate the mood and stress perceived by patients with blood glucose levels and glycemic variability. A hypothesis test was carried out to quantitatively compare the data groups of the different measures using the Student’s t-test. Results: Statistically significant differences (p-value < 0.05) were found between different levels of stress. In general, average glucose and variability decrease when the patient is calm. There are statistically significant differences (p-value < 0.05) between different levels of mood. Variability increases when the mood changes from sad to happy. However, the patient’s average glucose decreases as the mood improves. Conclusions: Variations in mood and stress significantly influence blood glucose levels, and glycemic variability in the patients analyzed with type 1 diabetes mellitus. Therefore, they are factors to consider for improving glycemic control. The mean of daily differences does not seem to be a good indicator for variability.
Dynamic Changes of Platelet and Factors Related Dengue Haemorrhagic Fever: A Retrospective Study in Indonesian
Authors: Faridah Imaniar Noor , Dania Haafizah , Chen Yen-Hsu , Supadmi Woro , Purwanto Barkah Djaka , Heriyanto Mochammad Junaidy , Aufa Mahda Adil , Chang Wei-Chiao , Perwitasari Dyah Aryani
Published: April 2022

Dengue is a viral infection caused by the dengue virus (DENV). Dengue infection is a self-limited acute febrile illness caused by four serotypes of DENV (DENV-1~4). Early recognition of high-risk patients would be helpful to reduce mortality rates and prevent severe dengue. Our study aimed to identify factors related to dengue hemorrhagic fever (DHF) based on admission-day data, and further to understand the distribution of biochemical laboratory data in dengue patients. This retrospective study was conducted in hospitals in Yogyakarta city, Indonesia, and involved febrile patients who were admitted to the hospital with a diagnosis of dengue during 2018 and 2020. Logistic regression models were used to identify variables related to DHF. In this study, 1087 patients were included as suspected dengue patients, among them 468 had dengue fever (DF) and 619 had DHF. Over half of the DHF patients were males (55.9%) with an average age of 17.9 years, and with a secondary infection (71.3%). By a multivariate analysis, on-admission laboratory data of thrombocytopenia and hemoglobin showed significant association with DHF. Furthermore, DHF patients had significantly prolonged hospitalizations compared to DF patients. In conclusion, on-admission platelet counts and hemoglobin laboratory data are useful as predictors of DHF especially for suspected dengue patients with the limitations of diagnostic tests.