bluuebunny/crossref_metadata_2025 huggingface dataset:
Retrospective cohort study to examine the association between serum amylase and the incidence of type 2 diabetes mellitus, Toranomon Hospital Health Management Center Study 23 (TOPICS 23)
Authors: Ikeda Izumi , Fujihara Kazuya , Osawa Taeko , Takeda Yasunaga , Hatta Mariko , Matsubayashi Yasuhiro , Kodama Satoru , Mori Yasumichi , Kadowaki Takashi , Honda Ritsuko , Arase Yasuji , Sone Hirohito
Published: July 2023

Introduction

Low serum amylase values are cross-sectionally associated with the prevalence of type 2 diabetes mellitus (T2DM) but have not been shown to be longitudinally associated with its incidence. This retrospective cohort (ie, historical cohort) study aimed to examine the association of previously lowered levels of serum amylase with incident T2DM.

Research design and methods

Examined were 8316 individuals who had annual health examinations for 6 years (ie, 7 times) at the Toranomon Hospital Health Management Center. The trajectory of serum amylase as the study exposure was classified into two elements: (1) serum amylase level at entry and (2) change in serum amylase, which was expressed as the annual change rate. The annual change rate was calculated by dividing the change in the amylase values according to follow-up periods. Regression analyses were performed to examine the association between low and decreased levels of serum amylase and the incidence of T2DM.

Results

Analyzed were 6917 individuals who had not developed T2DM within 1 year after cohort entry. T2DM thereafter occurred in 1021 patients. Cox regression indicated that the adjusted HR (95% CI) for incident T2DM for amylase ≤57 IU/L (quintile (Q) 1) was 0.97 (0.84 to 1.13) compared with amylase ≥58 IU/L (Q2–Q5). Logistic regression indicated that the adjusted OR (95% CI) for an annual change rate of amylase ≤−2.0% (Q1) vs ≥−1.9% (Q2–Q5) was 3.53 (3.00 to 4.16). The adjusted ORs were consistently significant throughout sensitivity analyses according to baseline amylase and the combination of age, body mass index, and hemoglobin A1c.

Conclusions

Results showed that not low but previously decreased serum amylase was a risk factor for T2DM, suggesting the significance of periodic examinations of serum amylase values to detect individuals at high risk of T2DM.
Pregnancy, fetal, and neonatal outcomes after a first booster dose of covid-19 vaccine during pregnancy in Ontario, Canada: population based, retrospective cohort study
Authors: Fell Deshayne B , Dimanlig-Cruz Sheryll , Török Eszter , Håberg Siri E , Regan Annette K , Kaufman Jay S , Platt Robert W , Gravel Christopher A , Bruce Liam , Shah Prakesh S , Wilson Kumanan , Sprague Ann E , Alton Gillian D , Dhinsa Tavleen , El-Chaâr Darine , Buchan Sarah A , Kwong Jeffrey C , Wilson Sarah E , Dunn Sandra I , MacDonald Shannon E , Barrett Jon , Okun Nannette , Walker Mark C
Published: July 2023

Objective

To assess risk of adverse pregnancy, fetal, and neonatal outcomes after a third dose (first booster dose) of covid-19 vaccine during pregnancy among individuals who had completed both doses of primary covid-19 vaccine series before pregnancy.

Design

Population based, retrospective cohort study.

Setting

Ontario, Canada, from 20 December 2021 to 31 August 2022.

Participants

Individuals were included if they were pregnant with an expected date of delivery from 20 December 2021 (start date of third dose eligibility for everyone ≥18 years) to 31 August 2022, who had completed the two doses of primary covid-19 messenger RNA vaccine series before pregnancy, and became eligible for a third dose (≥six months since dose two) before the end of pregnancy.

Main outcome measures

Pregnancy outcomes included hypertensive disorders of pregnancy, placental abruption, caesarean delivery, chorioamnionitis, and postpartum hemorrhage. Fetal and neonatal outcomes included stillbirth, preterm birth, admission to neonatal intensive care unit for >24 h, newborn 5 min Apgar score <7, and small-for-gestational age infant (<10th percentile). We estimated hazard ratios and 95% confidence intervals for study outcomes, treating dose three as a time varying exposure and adjusting for confounding using inverse probability weighting.

Results

Among 32 689 births, 18 491 (56.6%) were born to individuals who received a third covid-19 dose during pregnancy. Compared with eligible individuals who did not receive a third dose during pregnancy, no increased risks were associated with receiving a third covid-19 vaccine dose during pregnancy for placental abruption (adjusted hazard ratio 0.84 (95% confidence interval 0.70 to 1.02)), chorioamnionitis (0.67 (0.49 to 0.90)), postpartum haemorrhage (1.01 (0.89 to 1.16)), caesarean delivery (0.90 (0.87 to 0.94)), stillbirth (0.56 (0.39 to 0.81)), preterm birth (0.91 (0.84 to 0.99)), neonatal intensive care unit admission (0.96 (0.90 to 1.03)), 5 min Apgar score<7 (0.96 (0.82 to 1.14)), or small-for-gestational age infant (0.86 (0.79 to 0.93)).

Conclusion

Receipt of a third covid-19 vaccine dose during pregnancy was not associated with an increased risk of adverse pregnancy, fetal, or neonatal outcomes. These findings can help to inform evidence based decision making about the risks and benefits of covid-19 booster doses during pregnancy.
Burden of COPD in China and the global from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019
Authors: Li Min , Chen Hanxiang , Zhou Na , Zhang Ping , Duan Shengnan , Wu Taihua , Yi Yuanyuan , Yuan Ni
Published: July 2023

Objective

To investigate the current disease burden of chronic obstructive pulmonary disease (COPD) in China and globally using the Global Burden of Disease (GBD) data in 2019, as well as to analyse the changes in its risk factors, providing a scientific basis for the formulation of a comprehensive prevention and control strategy for COPD in China.

Study design

An observational study based on the GBDs.

Methods

Based on the GBD 2019 database, we obtained data on incidence, prevalence, mortality, disability-adjusted life years (DALYs) and corresponding age-standardised rates of COPD in China and the global, and analysed and described the changing trends of COPD burden in China and the global from 1990 to 2019.

Results

In 2019, the total number of COPD deaths in China was 1.04 (95% uncertainty intervals (95% UI): 0.89–1.27) million cases, the number of patients with COPD was 45.16 (95% UI: 41.13–49.62) million cases, and the number of new cases was 4.0 (95% UI: 3.6–4.4) million cases. DALYs were 74.4 (95% UI: 68.2–80.2) million years. Compared with 1990, the number of new incident cases and the overall prevalence of COPD in China in 2019 increased by 66.20% and 66.76%, respectively, which is lower than the overall global level.

Conclusion

From 1990 to 2019, the age-standardized prevalence rate (ASPR), the age-standardized incidence rate (ASIR) and the age-standardized death rate (ASDR) in China and the global all showed a downward trend, and the rate of decline in China was much higher than the overall level of the world, indicating that China has made specific achievements in the prevention and treatment of COPD, but overall the disease burden of COPD is still hefty, and the number of affected individuals is still increasing.
The perils and promises of generative artificial intelligence in neurointerventional surgery
Authors: Ray Tyler R , Kellogg Ryan T , Fargen Kyle M , Hui Ferdinand , Vargas Jan
Published: July 2023

Generative artificial intelligence (AI) holds great promise in neurointerventional surgery by providing clinicians with powerful tools for improving surgical precision, accuracy of diagnoses, and treatment planning. However, potential perils include biases or inaccuracies in the data used to train the algorithms, over-reliance on generative AI without human oversight, patient privacy concerns, and ethical implications of using AI in medical decision-making. Careful regulation and oversight are needed to ensure that the promises of generative AI in neurointerventional surgery are realized while minimizing its potential perils.

[ChatGPT authored summary using the prompt “In one paragraph summarize the promises and perils of generative AI in neurointerventional surgery”.]
The effects of cetuximab and cisplatin anti-cancer drugs on the mechanical properties of the lung cancerous cells using atomic force microscope
Authors: Rezaei Iraj , Sadeghi Ali
Published: July 2023

Each anti-cancer drug has special effects on the target cells. One of the most important reasons to recommend an anti-cancer drug is related to the influences of it on the mechanical properties of the target cells. In this study, the effects of cetuximab and cisplatin anti-cancer drugs on the mechanical properties of A-549 and Calu-6 cells as the cancerous lung cells have been investigated. For both of the cells and anti-cancer drugs, MTT assessment has been used to define the convenient dosages for 24 and 48 h incubations based on IC50 concentration for the cell line viability. The mechanical specifications of the cells before and after treatment were obtained using nanoindentation by the JPK Instruments’ NanoWizard3 atomic force microscope. The results show that cetuximab increases the stiffness of A-549 cell from 1225 to 3403 and 12 690 Pa for 24 and 48 h incubations. The influence of cetuximab on the Calu-6 shows that the elastic modulus after 24 and 48 h culture times increases about cisplatin anti-cancer drug, for A-549 cell indicates that the elastic modulus rises from 1225 to 1506 and 2375 Pa for 24 and 48 h, respectively. For Calu-6 cell, cisplatin has an important role to increase the stiffness of the cell. Applying cisplatin increases the elastic modulus from 33 to 682.8 Pa for 24 h and 1105 Pa after 48 h incubations.
Location–allocation strategies for traffic counters—a citywide deployment
Authors: Wu Mingjian , Kwon Tae J.
Published: July 2023

This study presents an innovative geostatistical approach, namely network regression kriging (NRK), for optimizing location–allocation of traffic counters within a road network. Long-term traffic observations for different road types are utilized by combining several semivariograms to better represent traffic behaviours. This location optimization problem minimizes the NRK estimation variance of traffic volumes via the simulated annealing algorithm. A real-world case study in Edmonton, Alberta, Canada, was used to illustrate the distinct features of our proposed approach. The results suggest that the generated traffic counters’ configurations can significantly improve the estimation accuracies. An effort was also made to reduce the number of traffic counters while maintaining the same estimation accuracies, and the result indicated potential equipment savings for up to 46.13%. The findings of this study imply that the proposed approach could be used as a decision-support and performance evaluation tool for transportation authorities to deploy traffic counters and assess alternative deployment strategies.
New insights into endophytic fungi diversity and their potential correlation with polyphyllin levels of Paris polyphylla var. yunnanensis
Authors: Lan Juan , Liu Ting , Miao Liyun , Pei Ting , Gan Zhe , Lin Aihua , Geng Hong , Zhang Peng
Published: July 2023

Endophytes confer fitness advantages to host plants. However, the ecological communities of endophytic fungi in the different tissues (rhizomes, stems, and leaves) of Paris polyphylla and the relationship of their endophytic fungi with polyphyllin levels remain unclear. In this study, the community diversity and differences of endophytic fungi in the rhizomes, stems, and leaves of P. polyphylla var. yunnanensis were investigated, and a comprehensively diverse community of endophytic fungi was represented, including 50 genera, 44 families, 30 orders, 12 classes, and 5 phyla. Distributions of endophytic fungi differed greatly across the three tissues, with six genera common to all tissues, and 11, 5, and 4 genera specific to the rhizomes, stems, and leaves, respectively. Seven genera showed a significantly positive correlation to polyphyllin contents, indicating their potential roles in polyphyllin accumulation. This study provides valuable information for further research of the ecological and biological functions of endophytic fungi of P. polyphylla.
Challenges and opportunities for kitchen waste treatment—a review
Authors: Prepilková Veronika , Poništ Juraj , Schwarz Marián , Samešová Dagmar
Published: July 2023

Kitchen waste presents a significant problem in waste management because of its large volume and other properties. Technologies for the treatment of kitchen waste are more or less tested in laboratory, semi-operational, or operational conditions. The main current technologies for the treatment of kitchen waste are anaerobic digestion, composting, incineration, and landfilling. However, new methods for kitchen waste treatment are currently being developed that combine the advantages and eliminate the disadvantages of current technologies. This review provides an overview, critically comparing the current methods of kitchen waste treatment. The comparison has been made primarily from the point of view of environmental advantages and disadvantages. This review does not take into account economic factors, which are difficult to evaluate as their value has to be related to a specific process and unit of capacity. In addition, we summarize some innovative methods for kitchen waste treatment that have already been tested under laboratory conditions.
Extended quasiparticle Padé approximation for non-Fermi liquids
Authors: Morawetz Klaus
Published: July 2023

The extended quasiparticle picture is adapted to non-Fermi systems by suggesting a Padé approximation which interpolates between the known small scattering-rate expansion and the deviation from the Fermi energy. The first two energy-weighted sum rules are shown to be fulfilled independent of the interpolating function for any selfenergy. For various models of one-dimensional Fermions scattering with impurities the quality of the Padé approximation for the spectral function is demonstrated and the reduced density matrix or momentum distribution is reproduced not possessing a jump at the Fermi energy. Though the two-fold expansion is necessary to realize the spectral function and reduced density, the extended quasiparticle approximation itself is sufficient for the description of transport properties due to cancellation of divergent terms under integration. The T-matrix approximation leads to the delay time as the time two particles spend in a correlated state. This contributes to the reduced density matrix and to an additional part in the conductivity which is presented at zero and finite temperatures. Besides a localization at certain impurity concentrations, the conductivity shows a maximum at small temperatures interpreted as onset of superconducting behaviour triggered by impurities. The Tan contact reveals the same universal behaviour as known from electron–electron scattering.

Graphic abstract
Laws of Social Reproduction
Authors: Kotiswaran Prabha
Published: July 2023

Feminists have long demonstrated the invisibility of women's reproductive labor, performed in bearing and raising children, maintaining households, and socially sustaining male labor. Every wave of feminist struggle from the late nineteenth century onward has actively queried the inequalities that characterize women's performance of such work, variously referred to as unpaid domestic and care work, domestic labor, or care work. Robust traditions of scholarship on women's unpaid work animate various disciplines, often spilling into political struggles for adequate recognition of this work. As the pandemic has rendered visible once again the reproductive labor of women the world over, this article offers an overview of social reproduction theory, feminist legal theorizations of reproductive labor, and how we might recuperate a rich tradition of theorizing on social reproduction to develop a materialist approach to law's regulation of reproductive labor across the marriage-market spectrum with a view to social and economic justice.
Effect of Metal Chloride Impurities on Equilibrium Potential of Fe/FeCl2 in Eutectic LiCl-KCl
Authors: Newton Matthew , Merwin Augustus , McMurray Jake , Simpson Michael
Published: July 2023

In this study, interaction of dilute metal chloride solutes in molten eutectic LiCl-KCl was studied via equilibrium potential measurements. Open circuit potential (OCP) was measured between a pure iron rod and a Ag/AgCl reference electrode with concentration of FeCl2 varying from 0.2–1 mol% at 530 °C. The Nernst equation was used to calculate activity coefficient of FeCl2 based on OCP. Measurements were made in LiCl-KCl-FeCl2 with and without additions of 0.5 mol% CsCl, NaCl, and LaCl3. The activity coefficient of FeCl2 was found to be unaffected by these small concentrations of CsCl, LaCl3, and NaCl. However, there was observed evidence that the activity coefficient of FeCl2, above 0.8 mol% Fe, may be affected by the presence of LaCl3 at higher concentrations beginning around 0.5 mol% La. Over the full range of conditions tested, the activity coefficient of FeCl2 in molten LiCl-KCl ranged from 2.95 × 10−5 to 1.01 × 10−4.
Comparative Study of Techniques and Methods Used to Characterize Intergranular Corrosion in AA2024 Aluminum Alloy
Authors: Mondou Emilie , Duployer Benjamin , Tenailleau Christophe , Andrieu Eric , Sinopoli David , Blanc Christine
Published: July 2023

Three methodologies, i.e., optical microscope (OM) observations, analyses using tomography without synchrotron radiations, and mechanical tests, were used, and their relevancy compared to provide a quantitative description of the intergranular corrosion (IGC) damage. The study was performed on three plates of 2024 aluminum alloy, to take into account variations in the microstructure of the material, using two types of exposure conditions, i.e. continuous immersions and cyclic tests. The resolution of tomography was too low to allow an analysis at the scale of the elementary IGC defects. For thin plates with recrystallized grains, the corrosion damage corresponded mostly to intragranular corrosion, and OM observations were the most relevant technique to quantify correctly this damage. Thicker plates were mainly affected by IGC. Continuous immersion tests led to slightly branched IGC defects and low hydrogen uptake, and OM observations provided an accurate description of the IGC damage that corresponded mainly to a geometrical one. However, combining OM observations and mechanical tests was required for a full description of the IGC damage after cyclic tests that were associated with a strong branching of the IGC defects, i.e. geometrical damage, and significant hydrogen uptake, i.e., a non-negligible volume damage.
Operation of NiO/β-(Al0.21Ga0.79)2O3/Ga2O3 Heterojunction Lateral Rectifiers at up to 225 °C
Authors: Wan Hsiao-Hsuan , Li Jian-Sian , Chiang Chao-Ching , Xia Xinyi , Ren Fan , Masten Hannah N. , Lundh James Spencer , Spencer Joseph A. , Alema Fikadu , Osinsky Andrei , Jacobs Alan G. , Hobart Karl , Tadjer Marko J. , Pearton S. J.
Published: July 2023

The characteristics of NiO/β-(Al0.21Ga0.79)2O3/Ga2O3 heterojunction lateral geometry rectifiers with the epitaxial layers grown by metal organic chemical vapor deposition were measured over a temperature range from 25 °C–225 °C. The forward current increased with temperature, while the on-state resistance decreased from 360 Ω.cm2 at 25 °C to 30 Ω.cm2 at 225 °C. The forward turn-on voltage was reduced from 4 V at 25 °C to 1.9 V at 225 °C. The reverse breakdown voltage at room temperature was ∼4.2 kV, with a temperature coefficient of −16.5 V K−1. This negative temperature coefficient precludes avalanche being the breakdown mechanism and indicates that defects still dominate the reverse conduction characteristics. The corresponding power figures-of-merit were 0.27–0.49 MW.cm−2. The maximum on/off ratios improved with temperature from 2105 at 25 °C to 3 × 107 at 225 °C when switching from 5 V forward to 0 V. The high temperature performance of the NiO/β-(Al0.21Ga0.79)2O3/Ga2O3 lateral rectifiers is promising if the current rate of optimization continues.
LGBTQI+ Experiences of HIV Management Services at Primary Healthcare Facilities in Gauteng Province, South Africa
Authors: Mulemfo Desirée Morakane , Moyo Idah , Mavhandu-Mudzusi Azwihangwisi Helen
Published: July 2023

Lesbian, gay, bisexual, transgender, queer, intersex, and plus (LGBTQI+) people are still discriminated against in South Africa, irrespective of their protection by the constitution of South Africa. The study explores the experiences of LGBTQI+ people when accessing HIV management services at public primary healthcare (PHC) facilities in Gauteng Province. Interpretive phenomenological analysis (IPA) was used. Data were collected through in-depth face-to-face interviews with six individuals who self-identified as LGBTQI+. The interviews were audio recorded with the permission of the participants. The data were transcribed verbatim and analyzed using the IPA framework. The findings indicate that LGBTQI+ people are marginalized, discriminated against, and stigmatized in the public PHC system, exposing them to unequal access to healthcare services. The heterocentric system disadvantages them from accessing specific HIV management services and appropriate preventive commodities. The study concludes that gender diversity, inclusion and sensitivity in healthcare provision, and specific LGBTQI+ training for healthcare providers, are crucial components of ensuring LGBTQI+ people’s access to quality HIV management services.
A Reliable and Effective UPLC-MS/MS Method for the Determination of Oprozomib in Rat Plasma
Authors: Li Xia , Liu Ya-nan , Zhang En , Xu Ren-ai , Yang Tingyong , Luo Shunbin
Published: July 2023

Oprozomib, as a second-generation orally bioavailable protease inhibitor (PI), is undergoing clinical evaluation for the treatment of haematological malignancies. In relapsed refractory multiple myeloma (RRMM) patients, oprozomib has shown good efficacy as a single agent or combination therapy. In this experiment, our purpose was to validate a sensitive and rapid method for the determination of oprozomib concentration in rat plasma by ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The samples were treated with acetonitrile as the precipitant and separated by gradient elution using a Waters Acquity UPLC BEH C18 column (2.1 mm × 50 mm, 1.7 μm). Using the selective reaction monitoring (SRM) method, the measurement was finished with the ion transitions of m/z 533.18 ⟶ 199.01 for oprozomib and m/z 493.03 ⟶ 112.03 for tepotinib (internal standard, IS), respectively. Meanwhile, acetonitrile and 0.1% formic acid aqueous solution were used as the mobile phase, and the flow rate was 0.3 mL/min. The lower limit of quantification (LLOQ) of the method was 1.0 ng/mL, and the linear relationship was good in the range of 1.0–100 ng/mL. In addition, the precision of four concentration levels was determined with the values of 3.1–7.3% and the accuracy was from −14.9% to 12.9%. Moreover, the recovery was determined to be from 85.1% to 96.1%, and the values of matrix effect were no more than 110.4%. The optimized UPLC-MS/MS method was also suitable for the pharmacokinetic study of rats after a single oral administration of 21 mg/kg oprozomib.
Fuzzy Comprehensive Evaluation Model of Project Investment Risk Based on Computer Vision Technology
Authors: Wang Hongjian
Published: July 2023

With the development of the economy and real-time embedded systems and the progress of science and technology, people’s economic income forms have undergone tremendous changes, and the concept of financial management has become clearer in people’s property income arrangements. Project investment is one of the most popular financial management methods in the era of big data. Both large enterprise groups and individual petty bourgeoisie groups have begun to pay attention to the risks and benefits brought by the new financial management method of project investment. This paper’s goal is to develop a fuzzy comprehensive evaluation (FCE) model for project investment risk based on computer vision technology and explore the application of computer vision technology in project investment risk evaluation. This article first uses a real-time embedded system to understand the basic process of project investment and select 10 investment experts for risk assessment, risks, and causes of the risks through literature research and case analysis. Then, this paper establishes a model of fuzzy comprehensive evaluation of project investment risk through computer vision technology, real-time embedded systems, and neural network models in big data and artificial intelligence technology to realize the analysis and prediction of project investment risk. The fuzzy comprehensive evaluation method and analytic hierarchy process (AHP) are used in this evaluation model to evaluate and forecast project investment risks. In addition, this paper also trains and tests the risk evaluation model of this research through the support vector machine classification algorithm, the real-time embedded system, and the average random consistency index. The research shows that the fuzzy comprehensive evaluation model of this study has higher accuracy for project investment risk evaluation than other risk evaluation methods. For example, for the investment risk of chemical fiber projects, this research model evaluated the factors such as organization, management, technology, and economy and found that the risks were all higher than 21.36%, which concluded that the overall investment risk of chemical fiber projects was relatively high.
Assessing the Complexity of Potential Bicycle Interference on Vehicles on Urban Road Segments
Authors: Wang Shihan , Ni Ying , Li Jianqiang
Published: July 2023

Interacting with bicycles on urban road segments is complex for vehicles, due to the diverse and flexible cycling behavior that can cause interferences. Studies show that driving mixed with bicycles is also a great challenge for autonomous vehicles (AVs), and it is necessary to consider the interference of bicycles when selecting public roads for testing. However, existing road evaluation methods mostly focus on autonomous driving functions and accident analysis, although bicycles have been considered, often with insufficient consideration of their interference. This study analyzes two types of cycling behavior that could interfere with vehicles, including lateral (turning handlebars) and longitudinal (braking or accelerating) behavior, with each occurrence of such behavior considered as one potential lateral or longitudinal interference. From the perspective of cycling behavior, a framework is proposed to assess the complexity of potential bicycle interference on vehicles on road segments. A higher frequency of both potential lateral and longitudinal interference represents a higher complexity of potential interference. A naturalistic field experiment was conducted to collect the potential lateral and longitudinal interference frequency and the environmental parameters of road segments. The quantile regression model was applied to analyze the environmental factors influencing different interference frequencies separately and further establish the assessing model of the potential bicycle interference complexity, and the usability of the model has been demonstrated with a case study. Results show that the potential interference complexity varies across road segments, with some factors leading to more frequent potential lateral and longitudinal interference but with varying degrees of impact (such as the separation between bicycles and vehicles), while some only affect the lateral interference frequency (such as the on-street parking condition). The proposed framework can help autonomous driving companies or evaluation agencies to select appropriate testing roads, thus promoting the development of autonomous driving.
Supplemental Table 3 from Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas
Authors: Yu Ming , Carter Kelly T. , Baker Kelsey K. , Redman Mary W. , Wang Ting , Vickers Kathy , Li Christopher I. , Cohen Stacey A. , Krane Mukta , Ose Jennifer , Gigic Biljana , Figueiredo Jane C. , Toriola Adetunji T. , Siegel Erin M. , Shibata David , Schneider Martin , Ulrich Cornelia M. , Dzubinski Lynda A. , Schoen Robert E. , Grady William M.
Published: July 2023

Supplemental Table 3: Summary patient characteristics for Comparison Set 2
Supplementary Table 5 from Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype
Authors: Kim Jihye , Yuan Chen , Amundadottir Laufey T. , Wolpin Brian M. , Klein Alison P. , Risch Harvey A. , Kraft Peter
Published: July 2023

Table S5 presents adjusted associations of ABO blood group alleles and pancreatic cancer risk, stratified by Lewis antigen and cohorts, and interactions between ABO blood group alleles and Lewis antigen.
Supplementary Table 4 from Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype
Authors: Kim Jihye , Yuan Chen , Amundadottir Laufey T. , Wolpin Brian M. , Klein Alison P. , Risch Harvey A. , Kraft Peter
Published: July 2023

Table S4 presents adjusted associations of ABO blood group alleles and pancreatic cancer risk by Lewis antigen and interactions between ABO blood group alleles and Lewis antigen.
Supplemental Table 1 from Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas
Authors: Yu Ming , Carter Kelly T. , Baker Kelsey K. , Redman Mary W. , Wang Ting , Vickers Kathy , Li Christopher I. , Cohen Stacey A. , Krane Mukta , Ose Jennifer , Gigic Biljana , Figueiredo Jane C. , Toriola Adetunji T. , Siegel Erin M. , Shibata David , Schneider Martin , Ulrich Cornelia M. , Dzubinski Lynda A. , Schoen Robert E. , Grady William M.
Published: July 2023

Supplemental Table 1: Primer/probe sequences used in the duplex mEVL assay
Supplemental Figure 1 from Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas
Authors: Yu Ming , Carter Kelly T. , Baker Kelsey K. , Redman Mary W. , Wang Ting , Vickers Kathy , Li Christopher I. , Cohen Stacey A. , Krane Mukta , Ose Jennifer , Gigic Biljana , Figueiredo Jane C. , Toriola Adetunji T. , Siegel Erin M. , Shibata David , Schneider Martin , Ulrich Cornelia M. , Dzubinski Lynda A. , Schoen Robert E. , Grady William M.
Published: July 2023

Supplemental Figure 1. Flowchart of patient selection. * Subjects with hereditary conditions or inflammatory bowel disease (IBD) were excluded. A flowchart showing the selection process for the subjects included in the studies is shown. The primary exclusion criteria that affected subject selection were lack of serial colonoscopy data and lack of tissue from the normal colon
Supplementary Table S9 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Authors: King Sontoria D. , Veliginti Swathi , Brouwers Martijn C.G.J. , Ren Zhewen , Zheng Wei , Setiawan Veronica W. , Wilkens Lynne R. , Shu Xiao-Ou , Arslan Alan A. , Beane Freeman Laura E. , Bracci Paige M. , Canzian Federico , Du Mengmeng , Gallinger Steven J. , Giles Graham G. , Goodman Phyllis J. , Haiman Christopher A. , Kogevinas Manolis , Kooperberg Charles , LeMarchand Loic , Neale Rachel E. , Visvanathan Kala , White Emily , Albanes Demetrius , Andreotti Gabriella , Babic Ana , Berndt Sonja I. , Brais Lauren K. , Brennan Paul , Buring Julie E. , Rabe Kari G. , Bamlet William R. , Chanock Stephen J. , Fuchs Charles S. , Gaziano J. Michael , Giovannucci Edward L. , Hackert Thilo , Hassan Manal M. , Katzke Verena , Kurtz Robert C. , Lee I.-Min , Malats Núria , Murphy Neil , Oberg Ann L. , Orlow Irene , Porta Miquel , Real Francisco X. , Rothman Nathaniel , Sesso Howard D. , Silverman Debra T. , Thompson Ian M. , Wactawski-Wende Jean , Wang Xiaoliang , Wentzensen Nicolas , Yu Herbert , Zeleniuch-Jacquotte Anne , Yu Kai , Wolpin Brian M. , Duell Eric J. , Li Donghui , Hung Rayjean J. , Perdomo Sandra , McCullough Marjorie L. , Freedman Neal D. , Patel Alpa V. , Peters Ulrike , Riboli Elio , Sund Malin , Tjønneland Anne , Zhong Jun , Van Den Eeden Stephen K. , Kraft Peter , Risch Harvey A. , Amundadottir Laufey T. , Klein Alison P. , Stolzenberg-Solomon Rachael Z. , Antwi Samuel O.
Published: July 2023

Supplementary Table S9 shows descriptive Statistics for PanScan sample
Supplementary Table 3 from Sources of Disparities in Surveillance Mammography Performance and Risk-Guided Recommendations for Supplemental Breast Imaging: A Simulation Study
Authors: Hubbard Rebecca A. , Pujol Toyya A. , Alhajjar Elie , Edoh Kossi , Martin Melissa L.
Published: July 2023

Supplementary Table 3. Sensitivity and cancer risk prediction logistic regression model coefficients
Supplementary Table S10 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Authors: King Sontoria D. , Veliginti Swathi , Brouwers Martijn C.G.J. , Ren Zhewen , Zheng Wei , Setiawan Veronica W. , Wilkens Lynne R. , Shu Xiao-Ou , Arslan Alan A. , Beane Freeman Laura E. , Bracci Paige M. , Canzian Federico , Du Mengmeng , Gallinger Steven J. , Giles Graham G. , Goodman Phyllis J. , Haiman Christopher A. , Kogevinas Manolis , Kooperberg Charles , LeMarchand Loic , Neale Rachel E. , Visvanathan Kala , White Emily , Albanes Demetrius , Andreotti Gabriella , Babic Ana , Berndt Sonja I. , Brais Lauren K. , Brennan Paul , Buring Julie E. , Rabe Kari G. , Bamlet William R. , Chanock Stephen J. , Fuchs Charles S. , Gaziano J. Michael , Giovannucci Edward L. , Hackert Thilo , Hassan Manal M. , Katzke Verena , Kurtz Robert C. , Lee I.-Min , Malats Núria , Murphy Neil , Oberg Ann L. , Orlow Irene , Porta Miquel , Real Francisco X. , Rothman Nathaniel , Sesso Howard D. , Silverman Debra T. , Thompson Ian M. , Wactawski-Wende Jean , Wang Xiaoliang , Wentzensen Nicolas , Yu Herbert , Zeleniuch-Jacquotte Anne , Yu Kai , Wolpin Brian M. , Duell Eric J. , Li Donghui , Hung Rayjean J. , Perdomo Sandra , McCullough Marjorie L. , Freedman Neal D. , Patel Alpa V. , Peters Ulrike , Riboli Elio , Sund Malin , Tjønneland Anne , Zhong Jun , Van Den Eeden Stephen K. , Kraft Peter , Risch Harvey A. , Amundadottir Laufey T. , Klein Alison P. , Stolzenberg-Solomon Rachael Z. , Antwi Samuel O.
Published: July 2023

Supplementary Table S10 shows descriptive Statistics for PanC4 sample
Supplementary Table S3 from Development of a Breast Cancer Risk Prediction Model Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Korean Women
Authors: Choi Jihye , Ha Tae-Woong , Choi Hye-Mi , Lee Han-Byoel , Shin Hee-Chul , Chung Woosung , Han Wonshik
Published: July 2023

Relative risk and population distribution of NGRFs for breast cancer in Korean women
Supplementary Table S1 from Development of a Breast Cancer Risk Prediction Model Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Korean Women
Authors: Choi Jihye , Ha Tae-Woong , Choi Hye-Mi , Lee Han-Byoel , Shin Hee-Chul , Chung Woosung , Han Wonshik
Published: July 2023

Beta weights and number of breast cancer associated SNPs used to construct single PRS
Supplementary Figure S1 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Authors: King Sontoria D. , Veliginti Swathi , Brouwers Martijn C.G.J. , Ren Zhewen , Zheng Wei , Setiawan Veronica W. , Wilkens Lynne R. , Shu Xiao-Ou , Arslan Alan A. , Beane Freeman Laura E. , Bracci Paige M. , Canzian Federico , Du Mengmeng , Gallinger Steven J. , Giles Graham G. , Goodman Phyllis J. , Haiman Christopher A. , Kogevinas Manolis , Kooperberg Charles , LeMarchand Loic , Neale Rachel E. , Visvanathan Kala , White Emily , Albanes Demetrius , Andreotti Gabriella , Babic Ana , Berndt Sonja I. , Brais Lauren K. , Brennan Paul , Buring Julie E. , Rabe Kari G. , Bamlet William R. , Chanock Stephen J. , Fuchs Charles S. , Gaziano J. Michael , Giovannucci Edward L. , Hackert Thilo , Hassan Manal M. , Katzke Verena , Kurtz Robert C. , Lee I.-Min , Malats Núria , Murphy Neil , Oberg Ann L. , Orlow Irene , Porta Miquel , Real Francisco X. , Rothman Nathaniel , Sesso Howard D. , Silverman Debra T. , Thompson Ian M. , Wactawski-Wende Jean , Wang Xiaoliang , Wentzensen Nicolas , Yu Herbert , Zeleniuch-Jacquotte Anne , Yu Kai , Wolpin Brian M. , Duell Eric J. , Li Donghui , Hung Rayjean J. , Perdomo Sandra , McCullough Marjorie L. , Freedman Neal D. , Patel Alpa V. , Peters Ulrike , Riboli Elio , Sund Malin , Tjønneland Anne , Zhong Jun , Van Den Eeden Stephen K. , Kraft Peter , Risch Harvey A. , Amundadottir Laufey T. , Klein Alison P. , Stolzenberg-Solomon Rachael Z. , Antwi Samuel O.
Published: July 2023

Supplementary Figure S1 shows forest plot for minimally adjusted model for the PanScan sample.
Supplementary Figure S3 from Development of a Breast Cancer Risk Prediction Model Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Korean Women
Authors: Choi Jihye , Ha Tae-Woong , Choi Hye-Mi , Lee Han-Byoel , Shin Hee-Chul , Chung Woosung , Han Wonshik
Published: July 2023

Estimation of absolute risk of breast cancer by seven percentiles for women at different ages estimated using data from HEXA 1st. The absolute risk of developing breast cancer predicted by the multiple PRS model (PRS38_ASN+PRS190_EB). The dotted lines represent the average risks. (A) Lifetime absolute risk (B) 5-year absolute risk
Supplementary Figure 2 from Intake of Proton-Pump Inhibitors and Gastric Cancer within the Stomach Cancer Pooling (StoP) Project
Authors: Sassano Michele , Mariani Marco , Pelucchi Claudio , Lunet Nuno , Morais Samantha , Martín Vicente , Moreno Victor , Curado Maria Paula , Dias-Neto Emmanuel , Leja Marcis , Gašenko Evita , La Vecchia Carlo , Boccia Stefania , Pastorino Roberta
Published: July 2023

Supplementary Figure 2: Pooled adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between intake of proton-pump inhibitors and gastric cancer, by smoking status and alcohol drinking status.
Data from Sources of Disparities in Surveillance Mammography Performance and Risk-Guided Recommendations for Supplemental Breast Imaging: A Simulation Study
Authors: Hubbard Rebecca A. , Pujol Toyya A. , Alhajjar Elie , Edoh Kossi , Martin Melissa L.
Published: July 2023

AbstractBackground:
Surveillance mammography is recommended for all women with a history of breast cancer. Risk-guided surveillance incorporating advanced imaging modalities based on individual risk of a second cancer could improve cancer detection. However, personalized surveillance may also amplify disparities.
Methods:
In simulated populations using inputs from the Breast Cancer Surveillance Consortium (BCSC), we investigated race- and ethnicity-based disparities. Disparities were decomposed into those due to primary breast cancer and treatment characteristics, social determinants of health (SDOH) and differential error in second cancer ascertainment by modeling populations with or without variation across race and ethnicity in the distribution of these characteristics. We estimated effects of disparities on mammography performance and supplemental imaging recommendations stratified by race and ethnicity.
Results:
In simulated cohorts based on 65,446 BCSC surveillance mammograms, when only cancer characteristics varied by race and ethnicity, mammograms for Black women had lower sensitivity compared with the overall population (64.1% vs. 71.1%). Differences between Black women and the overall population were larger when both cancer characteristics and SDOH varied by race and ethnicity (53.8% vs. 71.1%). Basing supplemental imaging recommendations on high predicted second cancer risk resulted in less frequent recommendations for Hispanic (6.7%) and Asian/Pacific Islander women (6.4%) compared with the overall population (10.0%).
Conclusions:
Variation in cancer characteristics and SDOH led to disparities in surveillance mammography performance and recommendations for supplemental imaging.
Impact:
Risk-guided surveillance imaging may exacerbate disparities. Decision-makers should consider implications for equity in cancer outcomes resulting from implementing risk-guided screening programs.
Data from Development of a Breast Cancer Risk Prediction Model Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Korean Women
Authors: Choi Jihye , Ha Tae-Woong , Choi Hye-Mi , Lee Han-Byoel , Shin Hee-Chul , Chung Woosung , Han Wonshik
Published: July 2023

AbstractBackground:
To develop a breast cancer prediction model for Korean women using published polygenic risk scores (PRS) combined with nongenetic risk factors (NGRF).
Methods:
Thirteen PRS models generated from single or multiple combinations of the Asian and European PRSs were evaluated among 20,434 Korean women. The AUC and increase in OR per SD were compared for each PRS. The PRSs with the highest predictive power were combined with NGRFs; then, an integrated prediction model was established using the Individualized Coherent Absolute Risk Estimation (iCARE) tool. The absolute breast cancer risk was stratified for 18,142 women with available follow-up data.
Results:
PRS38_ASN+PRS190_EB, a combination of Asian and European PRSs, had the highest AUC (0.621) among PRSs, with an OR per SD increase of 1.45 (95% confidence interval: 1.31–1.61). Compared with the average risk group (35%–65%), women in the top 5% had a 2.5-fold higher risk of breast cancer. Incorporating NGRFs yielded a modest increase in the AUC of women ages >50 years. For PRS38_ASN+PRS190_EB+NGRF, the average absolute risk was 5.06%. The lifetime absolute risk at age 80 years for women in the top 5% was 9.93%, whereas that of women in the lowest 5% was 2.22%. Women at higher risks were more sensitive to NGRF incorporation.
Conclusions:
Combined Asian and European PRSs were predictive of breast cancer in Korean women. Our findings support the use of these models for personalized screening and prevention of breast cancer.
Impact:
Our study provides insights into genetic susceptibility and NGRFs for predicting breast cancer in Korean women.
Data from Intake of Proton-Pump Inhibitors and Gastric Cancer within the Stomach Cancer Pooling (StoP) Project
Authors: Sassano Michele , Mariani Marco , Pelucchi Claudio , Lunet Nuno , Morais Samantha , Martín Vicente , Moreno Victor , Curado Maria Paula , Dias-Neto Emmanuel , Leja Marcis , Gašenko Evita , La Vecchia Carlo , Boccia Stefania , Pastorino Roberta
Published: July 2023

AbstractBackground:
A potential association between proton-pump inhibitors (PPI) and gastric cancer remains undefined. Thus, we aimed to evaluate such association within the Stomach cancer Pooling (StoP) Project.
Methods:
Data from five case–control studies of the StoP Project were included (1,889 cases and 6,517 controls). We assessed the impact of different exposure definitions, specifically any reported use of PPIs and exposure definitions based on the duration of PPI intake. Additionally, we modeled the dose–response relationship between the cumulative duration of PPI intake and gastric cancer.
Results:
Significant associations between PPI intake and gastric cancer, both overall and in the stratified analyses, were limited to exposure definitions based on short durations of intake. The overall odds ratio (OR) for any reported PPI intake was 1.78 [95% confidence interval (CI): 0.76–4.14]. In the dose–response analysis, the ORs of gastric cancer were found to be higher for short durations of PPI intake (6 months: OR 3.26; 95% CI: 2.40–4.42; one year: OR 2.14; 95% CI: 1.69–2.70; 2 years: OR 1.50; 95% CI: 1.22–1.85; 3 years: OR 1.27; 95% CI: 1.03–1.56), with the association becoming not significant for durations longer than 3 years.
Conclusions:
Our findings suggest that the observed association between PPIs and gastric cancer might be mainly due to reverse causality.
Impact:
The results of this study suggest that PPIs are a safe therapeutic choice regarding their effect on the occurrence of gastric cancer.
Supplementary Fig. 6 from An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor–Positive Breast Cancer
Authors: Chandarlapaty Sarat , Dickler Maura N. , Perez Fidalgo Jose Alejandro , Villanueva-Vázquez Rafael , Giltnane Jennifer , Gates Mary , Chang Ching-Wei , Cheeti Sravanthi , Fredrickson Jill , Wang Xiaojing , Collier Ann , Moore Heather M. , Metcalfe Ciara , Lauchle Jennifer , Humke Eric W. , Bardia Aditya
Published: July 2023

Supplementary Fig. S6. Detection of short variant gene alterations using the FACT next generation sequencing assay on ctDNA samples from patients dosed at 1400 mg dose (n=23).
Supplementary Fig. 5 from An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor–Positive Breast Cancer
Authors: Chandarlapaty Sarat , Dickler Maura N. , Perez Fidalgo Jose Alejandro , Villanueva-Vázquez Rafael , Giltnane Jennifer , Gates Mary , Chang Ching-Wei , Cheeti Sravanthi , Fredrickson Jill , Wang Xiaojing , Collier Ann , Moore Heather M. , Metcalfe Ciara , Lauchle Jennifer , Humke Eric W. , Bardia Aditya
Published: July 2023

Supplementary Fig. S5. Kaplan-Meier estimate of progression-free survival for patients with and without ESR1 mutations in baseline ctDNA samples collected from the 1400 mg dose group.
ESR1 data was available for 36 of 36 patients dosed at 1400 mg.
Supplementary Fig. 3 from An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor–Positive Breast Cancer
Authors: Chandarlapaty Sarat , Dickler Maura N. , Perez Fidalgo Jose Alejandro , Villanueva-Vázquez Rafael , Giltnane Jennifer , Gates Mary , Chang Ching-Wei , Cheeti Sravanthi , Fredrickson Jill , Wang Xiaojing , Collier Ann , Moore Heather M. , Metcalfe Ciara , Lauchle Jennifer , Humke Eric W. , Bardia Aditya
Published: July 2023

Supplementary Fig. S3. Clinical benefit does not correlate with ctDNA ESR1 mutant allele frequency (MAF) baseline levels or dynamics upon treatment, or with baseline ER and PR protein levels by IHC in tumor tissue.
Fig S1 from HCK Promotes High-grade Serous Ovarian Cancer Tumorigenesis through CD44 and NOTCH3 Signaling
Authors: Khella Christen A. , Franciosa Lucyann , Rodirguez-Rodriguez Lorna , Rajkarnikar Resha , Mythreye Karthikeyan , Gatza Michael L.
Published: July 2023

Distribution of clinical features associated with poor and good prognostic HGSOC patient samples in the TCGA U133A dataset.
Supplementary Figure 3 from Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression
Authors: Macke Amanda J. , Pachikov Artem N. , Divita Taylor E. , Morris Mary E. , LaGrange Chad A. , Holzapfel Melissa S. , Kubyshkin Anatoly V. , Zyablitskaya Evgeniya Y. , Makalish Tatiana P. , Eremenko Sergey N. , Qiu Haowen , Riethoven Jean-Jack M. , Hemstreet George P. , Petrosyan Armen
Published: July 2023

Figure S3. (A) Representative images of triple IHC staining of Integrin αvβ6 (green), Gal-3 (brown), and Na+/K+-ATPase (red) in normal prostate and tumor tissues from PCa patients with different grades. Deconvoluted images of Integrin αvβ6 are shown on the right; bars, 100 µm. (B) Quantification of Integrin αvβ6 H-score at PM from samples in A. Dunn Test (1964) Kruskal-Wallis multiple comparisons, p-adjusted using Benjamini-Hochberg; ****p<0.0001 and **p<0.01, median ± SD. (C) Quantification of Integrin αvβ6 and Gal-3 colocalization at PM in normal prostate and PCa, grades 2-5. Mann Whitney test; ***p<0.001, mean ± SD.