bluuebunny/crossref_metadata_2025 huggingface dataset:
Indicadores de rendimiento académico y aprobación del Examen Nacional de Residencias Médicas en dos modelos curriculares
Authors: Arellano Pérez Vertti Rubén Daniel , Carrillo Lucero Juan Manuel , Hernández Vallejo Claudia Leticia , Arellano Ramírez Daniel Orlando , Arellano Ramírez Diego Fernando , Galván Zermeño Rubén Darío
Published: October 2022

Introducción: En México, la mayoría de los estudiantes de medicina están interesados en realizar una especialidad médica. El médico general debe aprobar el Examen Nacional de Residencias Médicas, cuyo principal objetivo es seleccionar los mejores puntajes para realizar dicho curso en las sedes hospitalarias disponibles dentro del territorio mexicano. Muchas circunstancias influyen en la posibilidad de ser seleccionado para una especialidad, tales como el rendimiento académico, las estrategias de aprendizaje del estudiante, aspectos socioeconómicos, psicológicos y formativos, entre otros.

Objetivo: El propósito fue identificar y comparar entre dos modelos curriculares, indicadores de rendimiento académico asociados con la acreditación del examen nacional para el curso de residencias médicas.

Método: Estudio transversal comparativo en estudiantes pertenecientes a dos modelos curriculares en medicina. Se analizaron variables de rendimiento académico en los estudios de pregrado y los puntajes obtenidos en el Examen Nacional de Residencias Médicas.

Resultados: Se incluyeron 329 estudiantes; el promedio general de la carrera ≥87.61 se asoció a una mayor frecuencia de aprobados (88.8%); el modelo basado en competencias tuvo un mayor porcentaje (77.4%) de aprobados en el examen nacional. Los puntajes promedio de la licenciatura y ENARM fueron mayores para el modelo tradicional. Se observó una correlación significativa entre el promedio general de calificaciones y el puntaje en el examen nacional de residencias médicas (r = 585, p = 0.000).

Conclusiones: Estos resultados sugieren que el rendimiento académico, como el promedio general de calificaciones y los promedios de las áreas disciplinarias de 1º a 5º año de la licenciatura, se relacionan con la probabilidad de acreditar y obtener puntajes altos en el examen nacional de residencias médicas. El modelo curricular por competencias favoreció la acreditación del Examen Nacional de Residencias Médicas.
Políticas editoriales de revistas de Comunicación en acceso abierto indexadas en Scopus
Authors: Perdomo Bexi , Morales Oscar Alberto
Published: October 2022

Los autores de artículos necesitan información acerca de ciertas políticas editoriales (PE) de las revistas para elegir la que mejor responda a sus necesidades. Objetivo: caracterizar las tendencias en PE en las revistas de acceso abierto (AA) catalogadas en el área de Ciencias Sociales (CCSS) y en la subárea de Comunicación, en Scopus. Métodos: ésta fue una investigación descriptiva y transversal, apoyada en la bibliometría en la que se analizaron 77 revistas. Resultados: se observa el predominio de revistas con periodicidad semestral y del idioma inglés como lengua considerada por 90% de las revistas. Si bien la tendencia es normar la extensión de los artículos, ésta suele variar según género publicado y se mide en caracteres con espacios, palabras y páginas. En atención al cargo por procesamiento para AA, 55,8% no lo exige. Conclusión: las PE de estas revistas de AA en Scopus se traducen en ofrecer posibilidades de visibilidad a los autores y fortalecer la investigación de forma colaborativa.
TURISMO RURAL E AGRICULTURA FAMILIAR NO BRASIL: UM ESTUDO BIBLIOMÉTRICO
Authors: Strassburger Nândri Cândida , Coltre Sandra Maria , Camargo Welinton Ferreira
Published: October 2022

Os espaços rurais passaram por mudanças que alteraram suas características – que eram excepcionalmente agrícolas – para outras atividades, dentre elas, o turismo rural. A motivação central dessa atividade turística está relacionada aos aspectos do patrimônio, no sentido amplo, envolvendo a natureza, a cultura popular, a arquitetura, a gastronomia, os modos de vida e a história, entre outros. O presente estudo é um levantamento de cunho bibliométrico que analisou a produção científica relacionada ao portfólio de dissertações e teses que constam na base de dados da Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) que abordaram o tema turismo rural no contexto da agricultura familiar, defendidas entre os anos de 2010 e 2019, pela importância de entender essa atividade no meio rural. Em resposta à pergunta do estudo, os resultados demonstram que existe uma semelhança nos estudos relacionados ao turismo rural. Afinal, a grande maioria dos trabalhos tratou das fragilidades na elaboração de políticas públicas, voltadas ao desenvolvimento e assistência técnica da atividade desenvolvida pelos agricultores familiares. Identificou-se ainda que ações de sustentabilidade sugerem que o turismo rural pode ser considerado uma alternativa para o desenvolvimento rural sustentável, além de se propor a elaboração de indicadores para interpretação e análise.
INICIATIVAS DE COMPRAS PÚBLICAS DE PRODUTOS DA AGRICULTURA FAMILIAR PARA OS RESTAURANTES UNIVERSITÁRIOS
Authors: Triches Rozane Marcia , Ranzi Maria Eduarda , Paz Arruda Teo Carla Rosane , Nicolodi Francescato Ruiz Eliziane
Published: October 2022

Este artigo tem como objetivo analisar três casos de Restaurantes Universitários (RU) do sul do país que vêm comprando produtos da agricultura familiar (AF). Mais especificamente, verificar as formas utilizadas para compra de produtos de AF, identificar quais são os mecanismos de acesso construídos por parte das organizações de agricultores e gestores, bem como verificar os desafios e as articulações existentes entre atores públicos e privados que participam da elaboração e execução destas compras institucionais, observando semelhanças e diferenças entre os casos. A pesquisa se caracteriza como estudos de casos de caráter qualitativo, realizada a partir de 28 entrevistas semiestruturadas feitas com agentes sociais participantes deste processo analisadas por meio de análise de conteúdo. Verificou-se que a forma de gestão dos RU interfere nestas compras e que nos casos onde havia autogestão, as aquisições tinham mais êxito. No caso da gestão terceirizada, foi necessário inclusão de cláusulas nos editais para as compras ocorrerem. O papel dos atores sociais, suas interações e motivações foram determinantes na superação das dificuldades encontradas em todos os casos (logística, adaptação ao novo processo, organização). Os resultados mostram ser possível implementar as compras da agricultura familiar nos RU de forma satisfatória, e evidenciam a importância destas políticas que visam o desenvolvimento social, ambiental, econômico e da segurança alimentar e nutricional.
EDITORIAL
Authors: Ríos-Cardona Juan Camilo de los , Heindorf Claudia , Peralta-Rivero Carmelo , Fossá Juliano Luiz
Published: October 2022

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Detection of classⅠintegrons with phenotypic ESBL detection among enterobacteriaceae isolated from patients with urinary tract infection in Sulaimani provenance/ Iraq
Authors: Taha Abubaker Karzan , Anoar Khanda Abdullateef
Published: October 2022

Objectives: This study aims to evaluate class Ⅰ integrons and ESBL detection in members of Enterobacteriaceae obtained from Urinary tract infection samples.

Methods: Four hundred mid-stream urine sample were collected from patients admitting to Shar teaching hospital, Sulaimani teaching hospital, Anwar Shexa medical city hospital with signs and symptoms of UTI, and inoculated on different culture media. Colony morphology, gram staining, and VITEK 2 compact were used for bacterial identification, antibiotic profile and ESBL screened phenotypically by antibiotic profile results and double disk synergy test and confirmed by combined disk test methods. Conventional PCR was used to detect classⅠ Integron by using a specific primer and the result was analyzed, sequenced and uploaded into NCBI.

Results: Among four hundred samples the prevalence rate of Enterobacteriaceae was 67.03 which includes 86 E. coli, 32 Klebsiella pneumoniae, and two isolates of Proteus mirabilis, according to the antibiotic profile, the most sensitive antibiotic among all three isolates were Imipenem, meropenem, and nitrofurantoin, while most resistance antibiotic were nalidixic acid and third generation cephalosporin. The prevalence rate of ESBL-producing Enterobacteriaceae was 56.6% by the confirmatory test which was a combined disk test, and the prevalence rate of classⅠintegron was 54.2%.

Conclusion: A significant majority of the isolates under study had integrons gene and were ESBL positive. As a result, proactive antibiotic surveillance systems are required in both clinical and community settings in order to stop the occurrence and spread of antibiotic resistance genes among diverse bacterial species.
Misconceptions of COVID-19 pandemic among a sample of general public in Baghdad Iraq 2021: A Cross sectional survey
Authors: Jawad Hawraa Basim , Qasim Asmahan Abdul Kadhim
Published: October 2022

Objectives: to determine the misconceptions regarding COVID -19 pandemic among adults attending the three primary healthcare centers in Baghdad, Iraq.

Methods: Three primary health care centers were conveniently chosen to recruit adults attending them (using systematic sampling technique of every fifth attendee) and interview them to answer a special questionnaire form concerned with globally and locally spreading myths and misconceptions regarding COVID-19 pandemic and consisted of two part one for reporting demographic characteristics and the other consisted of 19 questions to assess people perceptions towards COVID-19 pandemic. Each question had two scores either zero for wrong response or one for correct one. Scores below 10 were considered bad perception and ≥10 were considered good perceptions.

Results: The study included 400 participants; 235 (58.8%) were females with a female: male ratio of 1.4:1, their age ranged from 18-82 years with a mean of 40.2 ± 14.6 years SD, more than half of them (224; 56.0%) were ≤40 years of age, 272 (68.0%) were either governmental employee or working in private sector, 214 (53.4%) were with college education and higher and 300 (75.0%) were ever married. Good perception scores were found in 21.2% of the participants, Males, younger age groups, higher educational levels, ever married participants and those who were working privately had higher proportions of good perceptions toward COVID-19 pandemic, yet the associations were only statistically significant with age group and educational level.

Conclusions: Good perception regarding COVID-19 pandemic was low.
Innovative learning - key question in teaching naval surgery
Authors: Utochkin A. P. , Loginov V. A. , Surov D. A. , Soloviev I. A. , Sizonenko N. A. , Silchenko E. S. , Kolodniy A. V.
Published: October 2022

Simulation training plays an important role in the preparation of future naval surgeons. In this regard, nowadays in the department of naval surgery there is a training simulator, modernized on the model of the most modern diesel submarine. In contrast to the previous simulator it contains necessary devices for solving situational tasks with the use of telemedicine technologies. The simulator is equipped with sanitary stretchers and a tripod with medical melts. It allows to organize a military medical game with the introductory on transporting conditionally sick and injured both inside and outside the ship that improves the quality of preparing future naval surgeons.
Overview On Neurogenic Bowel Dysfunction in Pediatrics
Authors: Abdelsamie Fadl Ahmed , Nawaf Raji D Alruwaili , Omar Jaber Bedair Nebras , Hassan Almousaedi Ibrahim , Salem Alwagdani Hadeel , Bassam Sindi Shahad , Abdulhakeem Hazazi Alhanoof , Shary J Hazazi Ahlam , Marah Wasel A Mukhtar , Wasel Alhashim Howra , Abdullah M Abdulhakeem , Abdulkareem Bin Amer Fatimah , Abdulrahman Mohammed Alomair
Published: October 2022

Neurogenic bowel dysfunction (NBD) is fecal incontinence or constipation which is prevalent in kids with both congenital and acquired neurological disorders. NBD results from loss of normal sensory or motor control and may include both the upper and the lower gastrointestinal (GI) tract Constipation and fecal incontinence are frequent symptoms of neurogenic bowel dysfunction (NBD), which makes it a challenging condition to treat. Also, they have a major impact on quality of life and dignity. Bowel dysfunction is less studied compared to neurogenic bladder, generally prevelant in spina bifida, but practically as prevalent in other neurological conditions. Generally, the objective of neurogenic bowel management is to achieve complete emptying of the rectum on a systematic basis. This may be accomplished through with a multidimensional approach containing of conservative, medical and even surgical approaches. A modified Delphi procedure was used to construct a statement document. This paper discusses the various causes of paediatric NBD. Our aim is to enhance clinical management, numerous therapeutic techniques are given. Due to both the improved survival rate and better diagnosis, there are more children and teenagers with NBD. The number of children and adolescents with NBD is growing as a result of better diagnosis and a greater survival rat NBD can cause either faecal incontinence or constipation, or both, with a fair amount of predictability. However, each patient will experience NBD in a different way depending on a variety of underlying conditions and coexisting conditions. Due to the status of the affected child and caregivers, management of NBD should be individualized using a combined multidisciplinary therapy.
Efficacy of hyperbaric oxygen therapy as a supplementary therapy of sudden sensorineural hearing loss in the Slovak Republic
Authors:   Faculty of Healthcare, Alexander Dubček University of Trenčín, Trenčín, Slovak Republic, Krajčovičová Zdenka , Meluš Vladimír ,   Faculty of Healthcare, Alexander Dubček University of Trenčín, Trenčín, Slovak Republic, Zigo Rastislav ,   Department of Otolaryngology, Faculty Hospital Trenčín, Trenčín, Slovak Republic, Matišáková Iveta ,   Faculty of Healthcare, Alexander Dubček University of Trenčín, Trenčín, Slovak Republic, Večeřa Ján ,   Department of Otolaryngology, Faculty Hospital Trenčín, Trenčín, Slovak Republic, Kašlíková Katarína ,   Faculty of Healthcare, Alexander Dubček University of Trenčín, Trenčín, Slovak Republic
Published: October 2022

We evaluated the efficacy of hyperbaric oxygen (HBO2) therapy used as a supplement to the first-line medical treatment of sudden sensorineural hearing loss (SSNHL). We tested 68 patients suffering from SSNHL within seven days of hearing loss: 21 patients received the standard treatment protocol of our department (control group) and 47 individuals were treated with an additional application of HBO2 therapy. Treatment success was assessed using pre- and post-treatment audiograms. Outcomes of our study showed a statistically significant improvement in auditory threshold in all frequency groups for the HBO2 group (P < 0.001), whereas in the control group the statistically significant mean auditory gain was observed only for the frequency zone 1,000 to 2,000 Hertz (P = 0.01). Furthermore, the rate of hearing gain in the HBO2 group was more than doubled (61.7%) compared to the control group (28.6%). Complete recovery of the hearing gain in the control group was observed only in the first two frequency groups (14.29%; 4.76%; 0.00%), whereas in the HBO2 group complete recovery was seen in all the frequency groups (19.15%; 21.13%; 6.38%) as well as in the whole frequency range (6.38%). The efficiency of both treatment protocols was statistically significant (P < 0.001) in both groups of patients, but supplementation of the therapy with HBO2 demonstrated a statistically significantly increase in the effect of pharmacotherapy (P < 0.001) by 11.5 decibels (dB) up to the final hearing gain of 20 dB. HBO2 is therefore a promising modality of SSNHL treatment, but specific mechanisms of HBO2 in patients with SSNHL arestill unknown. Further investigations are warranted to explore the mechanisms of action.
Parameter estimation and prediction uncertainties for multi-response kinetic models with uncertain inputs
Authors: Abdi Kaveh , Celse Benoit , McAuley Kimberley
Published: October 2022

Error-in-variables model (EVM) methods are used for parameter estimation
when independent variables are uncertain. During EVM parameter
estimation, output measurement variances are required as weighting
factors in the objective function. These variances can be estimated
based on data from replicate experiments. However, conducting replicates
is complicated when independent variables are uncertain. Instead,
pseudo-replicate runs may be performed where the target values of inputs
for repeated runs are the same, but the true input values may be
different. Here, we propose a method to estimate output-measurement
variances for use in multivariate EVM estimation problems, based on
pseudo-replicate data. We also propose a bootstrap technique for
quantifying uncertainties in resulting parameter estimates and model
predictions. The methods are illustrated using a case study involving
n-hexane hydroisomerization in a well-mixed reactor. Case-study results
reveal that assumptions about input uncertainties can have important
influences on parameter estimates, model predictions and their
confidence intervals.
Recurrent Neural Networks With Conformer for Speech Emotion Recognition
Authors: Sun Chenjing , Yang Jichen , Huang Xin , Hou Xianhua
Published: October 2022

Speech emotion recognition plays an important role in many applications,
but the task is challenging due to various factors such as background
noise, different speaker speech characteristics, etc. The well known
speech emotion recognition system ACRNN uses CNN to extract local
features of speech signals and attention mechanism focuses on the parts
with prominent emotions. However, it has no ability to capture long-term
global information and it also has no ability to jointly attend to the
information from different representation subspaces at different
positions because only one single attention module is used. In order to
settle out the drawbacks of ACRNN, CoRNN is proposed in this letter by
applying Conformer to replace the modules of CNN and attention module.
The experimental results on IEMOCAP dataset demonstrate the unweighted
average recall of the proposed CoRNN can achieve 65.53%, which improves
0.79% comparing with ACRNN.
Real-world HbF status in sickle cell disease from an endemic zone.
Authors: Pendharkar Dinesh , Nirmal GARIMA , Gupta Neha , Raj Abhishek
Published: October 2022

Introduction: Sickle cell disease is debilitating hereditary
disorder affecting large tribal population in certain parts of India.
Complications of sickle cell disease are veno-occlusive crisis, gall
stones, leg ulcers, stroke, anemia requiring transfusions adding to the
decreasing quality of life. Usage of hydroxyurea increase value of HbF
and thereby decreases the complications. To assess the real world
scenario of SCD patients, particularly, there levels of HbF, a random
clinical examination with blood sampling was initiated and compared to
baseline available data. Methods: Confirmed cases of
sickle cell disease attended special clinical camps. Patients of all age
group were invited to attend the camp. To assess the real world scenario
of SCD patients, particularly the levels of HbF, a questionnaire and a
random clinical examination with blood sampling was initiated and
compared to baseline available data. Results: One hundred
fourteen patients attended the camp. There were 68 males and 46 female
patients with a median age group of 19 years (2-70 years). HU was
prescribed on average considering age of the patient and average weight.
104 children were taking hydroxyurea. Exact dose calculations were not
used. The dose averages between 10 mg/kg to15 mg/kg. As there was only
one formulation available , the required daily dosing was changed to
fixed dose scheduling There was significant change in the levels of HbF
in the patients on hydroxyurea in all age groups using fixed dose
combination. Conclusions: The achievement of desired HbF target
levels using “real-world” scenario, compels us to think about HU
strategies. The practice of using fixed dose schedules, in real-time
clinical practice, with minimal follow up deserves a serious discussion
and could be of great use in low resource countries.
User Recognition of Devices on the Internet based on Heterogeneous Graph Transformer with Partial Labels
Authors: Ren Yimo , Li Hong , Liu Peipei , Liu Jie , Zhu Hongsong , Sun Limin
Published: October 2022

Recognizing the users of devices, who use IP addresses as unique
identity on the Internet, can easily enable numerous security
applications. Due to the lot’s kinds of device data and large number of
missing values, it is difficult to recognize the users of devices well.
The community detection methods based on Graph Neural Network (GNN) can
integrate multi-source data well to cluster devices into the community
with the same user, so as to realize user recognition of devices with
higher performance. While existing GNN methods face several issues that
the methods on homogeneous graphs could not utilize the multi-source
data of devices and most of the methods on heterogeneous graphs need
specific knowledge to design meta paths. Also, the web-scale Internet
data of devices make it hard for existing methods to learn the
representation fully. Finally, a majority of the methods above do not
consider the known partial labels in the early stage of training models,
not making full use of label information, leading to the effects
slightly insufficient. To improve the performance of user recognition,
this paper proposes HGT-PL, namely Heterogeneous Graph Transformer with
Partial Labels, to calculate the representation of devices on the
Internet, on which cluster methods are used to realize user recognition.
By using graph transformer, HGT-PL deeply learns node features and graph
structure on the heterogeneous graph of devices. By Label Encoder,
HGT-PL fully utilizes the users of partial devices from preliminary
rules with high confidence. By using cluster methods, the communities
with different users are carefully divided and modified. The paper
conducts experiments on the web-scale data collected from the Internet
and the results show that HGT-PL is able to recognize users of devices
more accurately and effectively, with 0.5121 NMI and 0.3554 ARI,
compared with existing GNN methods.
IoT and Drone Based Health Monitoring of Patients
Authors: S Meivel , Sindhwani Nidhi , Anand Rohit , Kannan Ramani
Published: October 2022

Without the use of medicine drones, users are responsible for transporting goods at a high cost. The goal of this patient monitoring system is to identify people’s health and, if necessary, administer medicine. The transportation drone is capable of finding healthcare information in a 360-degree rotation within the transportation infrastructure. Drone doctors are critical for the transportation of small gadgets such as drug treatments, blood leakages, and vaccines in the critical conditions of a heart patient, in event of failure of traffic location infrastructure, highway roads, or hospitals due to intense climate or site visitor congestion, and for the transportation of small gadgets such as drug treatments, blood leakages, and vaccines. When transmission is difficult, the self-maintaining drone is the format for quickly transporting drug treatments to the appropriate locations. The shipping drone equipped with an Ardupilot can drive in autopilot mode, which guides the drone to its destination. It has a 7-minute flying period and can deliver up to 2 kg of medicine. When the detected heartbeat is 94bpm and the fever range is 101 degree, a method has been presented in which an IoT Drone Doctor System distributes the first AID box to vulnerable patients and heart patients.
The impact of COVID-19 on pediatric adenoid hypertrophy in Beijing
Authors: Gao Yan , Li Zufei , Tai Jun
Published: October 2022

Objective: Since the outbreak of COVID-19, wearing masks and frequent
hand washing have become common phenomena. The purpose of this study was
to explore the impact of such lifestyle changes on adenoid hypertrophy
in children in Beijing. Methods: Baidu Index platform was used to search
with adenoid hypertrophy as the keyword, and the search volume of terms
from 2017 to 2021 was recorded weekly. Meanwhile, the visits to adenoid
hypertrophy in the otolaryngology department of Children’s Hospital,
Capital Institute of Pediatrics in the same period were collected and
compared, and analyzed. Results: (1) Baidu index indicated that the
following group of adenoid hypertrophy was mainly parents of
childbearing age, and female parents paid more attention;  (2) From 2017
to 2019, the online attention and outpatient visits to adenoid
hypertrophy increased year by year. After the COVID-19 outbreak, the
increasing trend declined and stagnated. Conclusions: After the outbreak
of COVID-19, epidemic prevention policies (wearing masks, hand hygiene,
reducing movement of people, etc.) have a certain inhibitory effect on
adenoid hypertrophy.  Keywords: adenoid hypertrophy, COVID-19, Baidu
Index platform, masks, hand hygiene Key points: Adenoid hypertrophy may
be associated with recurrent respiratory infections in childhood. After
the onset of COVID-19, China enacted many epidemic prevention policies.
Wearing masks and hand hygiene may reduce the incidence of respiratory
infections. Web data provides insight into the real needs of the
population. After the onset of COVID, there was a stagnation in network
attention and outpatient visit rates for adenoid hypertrophy.
Masks Thermal Degradation as an Alternative of Waste Valorization on the COVID-19 Pandemic: A Kinetic Study
Authors: Montero Carolina , Tacuri Roger , Solis Hugo , De-La-Rosa Andrés , Gordillo Gilda , Araujo-Granda Pablo
Published: October 2022

Kinetic modeling of thermal degradation process by pyrolysis as an
alternative for energy recovery of used masks generated by the COVID-19
pandemic. The masks were isolated for 72 h for virus inactivation and
characterized by FTIR-ATR spectroscopy, elemental analysis, and higher
heating value. Thermal degradation was performed by thermogravimetric
analysis at different heating rates on an inert atmosphere. The gases
produced were characterized by gas chromatography and mass spectrometry.
The kinetic model was developed based on weight loss and calculated
activation energies, reaction orders, pre-exponential factors, and
thermodynamic parameters. The best fit models were established between
the experimental and calculated data. Composition of the mask samples
were polypropylene, polyethylene terephthalate, nylon 6, and Spandex,
with higher calorific values than traditional fuels. The kinetic and
thermodynamic parameters of the pyrolysis processes demonstrated the
feasibility and high potential of recovery of these residues with
conversions higher than 89.26 %.
A Note about Mean Values in GSM Cell
Authors: Lebl Aleksandar , Mitic Dragan , Markov Zarko
Published: October 2022

In this short paper we consider a cell in the network of mobile users.
It is proved that the mean value of distance between a user and a base
station and the mean value of emission power to a user are calculated in
a different manner. These two values are calculated for three
characteristic user density distributions in a cell. In another way
defined, the mean value of emission power to a user differs from the
emission power to a user positioned on the mean distance from a base
station. The results are verified by simulation.
Normothermic perfusion of cirrhotic and non-cirrhotic explanted human livers: applicability to study drug pharmacokinetics
Authors: Stevens Lianne , Dubbeld Jeroen , Doppenberg Jason , Hoek Bart van , Menke Aswin , Donkers Joanne , Alsharaa Abdulnaser , Vries Arjan de , Vaes Wouter , Knibbe Catherijne , Steeg Evita van de , Alwayn Ian
Published: October 2022

Background and Purpose: Realistic models predicting hepatobiliary
processes in health and disease are lacking. We therefore aimed to
develop a physiologically relevant human liver model consisting of
normothermic machine perfusion (NMP) of explanted diseased human livers
that can be used to investigate hepatic first-pass, clearance, biliary
excretion and drug-drug interactions. Experimental approach: Eleven
livers were included in the study, seven with a cirrhotic and four with
a non-cirrhotic disease background. After explantation of the diseased
liver, the liver artery and portal vein were reconstructed followed by
NMP. After 120 minutes of perfusion, a drug cocktail (rosuvastatin,
digoxin, metformin and furosemide) was administered to the portal vein
and 120 minutes later, a second bolus of the drug cocktail was
co-administered with drug inhibitors to study relevant drug-drug
interactions. Key results: The explanted livers showed good viability
and functionality after explantation and 360 minutes of NMP. Hepatic
first-pass and clearance of rosuvastatin and digoxin showed to be the
most affected by cirrhosis with an increase in Cmax of 10.03 and 2.89
times, respectively, compared to non-cirrhotic livers. No major
differences were observed for metformin and furosemide. Drug-drug
interaction of rosuvastatin or digoxin with inhibitors were more
pronounced in non-cirrhotic livers compared to cirrhotic livers.
Conclusions and Implications: Our results demonstrated that explanted
cirrhotic and non-cirrhotic livers were suitable for NMP and we
demonstrated the applicability to study hepatic first pass, clearance,
biliary excretion and drug-drug interaction. This model can be applied
in a variety of research settings for hepatology, transplantation and
pharmacology
Integrative Transdisciplinarity:
Authors: Montuori Alfonso
Published: October 2022

Throughout the world there has been a sustained criticism of  current educational systems, which are viewed as unsustainable because inappropriate for an age of complexity. In this article I reflect on the development of what I call Integrative Transdisciplinarity,an approach to inquiry for individual scholars. Integrative Transdisciplinarity is grounded in systems and complexity thinking and frames inquiry as a creative process. I discuss the theoretical foundations of this approach with references to some of the ways in which it has been applied in a transdisciplinary doctoral program for almost 20 years.
Rethinking participation through dance: A historical-theoretical intersection
Authors: Njaradi Dunja
Published: October 2022

The paper deals with the idea of participation or community in dance. The idea of community has become key in contemporary discussions about the globalization of contemporary societies, and dance has a large share in the reflections of these global processes. Dance also has a very long tradition of community thinking. From this long and rich tradition, this paper will point out the ways in which the idea of community is reflected in social and artistic dances, pointing out both concrete dance forms and theoretical concepts, ideas and practices. Of the dance forms, the paper will discuss the tango pair dance, the flash mob dance-gathering form as well as the contact improvisation developed within postmodern dance. Of the theoretical and philosophical settings that underpin discussions of community in dance studies, the paper will discuss the concept of kinesthesia or ?kinesthetic empathy?, ?mirror neurons? in neuroscience as well as philosophical reflections on affect.
Periodontal changes following distraction osteogenesis in patients with cleft lip and palate: a clinical trial
Authors: Moussa Hassan , Fahmy Rania A. , Madi Marwa , Khalil Nesma Mohamed
Published: October 2022

Objectives

To evaluate inflammatory mediator levels and periodontal changes following distraction osteogenesis (DO) in patients with cleft lip and palate (CLP) using mid-maxillary distraction (MMD).

Materials and Methods

A total of 20 healthy patients with CLP with Class III malocclusion were included. Segmental forward advancement of the anterior maxilla from the second premolars on both sides using DO was performed. A custom-made, tooth-borne distractor connecting buccal molar segments to the anterior maxilla was used for 7 days with 0.5-mm distraction for the first 2 days and then increased to 1 mm daily until overcorrection. Crevicular interleukin IL-1β and tumor necrosis factor TNF-α levels were measured during distraction. Periodontal clinical parameters and indices were recorded at baseline and 3 and 6 months postoperatively. Soft tissue healing was evaluated histologically at 2 and 4 weeks after distraction.

Results

The periodontal parameters remained stable during the follow-up periods. Insignificant increases in the level of inflammatory cytokines compared with the control were observed. Histological findings revealed mild inflammatory and structural changes in the gingiva immediately after distraction, whereas regeneration was noticed after 4 weeks.

Conclusions

MMD was an effective technique in treating patients with CLP, leading to new bone and soft tissue formation without significant detrimental effect on the periodontium of the adjacent teeth.
Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog
Authors: Kraft Guillaume , Coate Katie C. , Smith Marta , Farmer Ben , Scott Melanie , Hastings Jon , Cherrington Alan D. , Edgerton Dale S.
Published: October 2022

Endogenous insulin secretion is a key regulator of postprandial hepatic glucose metabolism, but this process is dysregulated in diabetes. Subcutaneous insulin delivery alters normal insulin distribution, causing relative hepatic insulin deficiency and peripheral hyperinsulinemia, a major risk factor for metabolic disease. Our aim was to determine whether insulin’s direct effect on the liver is preeminent even when insulin is given into a peripheral vein. Postprandial-like conditions were created (hyperinsulinemia, hyperglycemia, and a positive portal vein to arterial glucose gradient) in healthy dogs. Peripheral (leg vein) insulin infusion elevated arterial and hepatic levels 8.0-fold and 2.8-fold, respectively. In one group, insulin’s full effects were allowed. In another, insulin’s indirect hepatic effects were blocked with the infusion of triglyceride, glucagon, and inhibitors of brain insulin action (intracerebroventricular) to prevent decreases in plasma free fatty acids and glucagon, while blocking increased hypothalamic insulin signaling. Despite peripheral insulin delivery the liver retained its full ability to store glucose, even when insulin’s peripheral effects were blocked, whereas muscle glucose uptake markedly increased, creating an aberrant distribution of glucose disposal between liver and muscle. Thus, the healthy liver’s striking sensitivity to direct insulin action can overcome the effect of relative hepatic insulin deficiency, whereas excess insulin in the periphery produces metabolic abnormalities in nonhepatic tissues.
İnanç, Kültür, Medeniyet ve Hoşgörü Bağlamında Osmanlı Devleti nin Yönetim Uygulamaları ve Gayrimüslim Kamu Görevlileri: Edirne Örneği
Authors: Ertan Mustafa Hakkı
Published: October 2022

Osmanlı Devleti, topraklarında yaşayan vatandaşlarının, tarihinin her döneminde, inançlarına saygı gösteren bir devlet anlayışını, uygulamalarla göstermiş bir devlettir. Bu saygı gereği Osmanlı coğrafyasında, her dine mensup insanlar ve bu insanların ibadethanelerini görebilmek olağan bir durumdur. Müslümanların dışında kalan gayrimüslim kesim, hayatın içinde ve her safhasında yer almış ve devletin önemli kesimlerinde görev yapabilmişlerdir. Osmanlı Devleti’nin sosyo-kültürel yapısı içerisinde, mevcut bulunan bütün cemaat ve cemiyetlere eşit muamelede bulunduğu, mevcut belgelerden ve konu ile ilgili, son dönem, Edirne Salnamelerden de anlaşılmaktadır. Edirne’nin Osmanlı asırlarında çok anlamlı bir yeri vardır. Devlete başkent olmuş bu önemli vilayetin, medeniyete mâl olmuş eserleri, hanları, hamamları, camileri ve dünya kültür tarihi açısından önemli işlev görmüş darüşşifası bu vilayetin önemini ayrıca arttırmıştır. Orta çağda engelli bireylerin ve psikolojik travmalar yaşayan insanların akıl almaz işkence gördükleri veya dışlandıkları bir dönemde, Osmanlı coğrafyasında kurulan darüşşifalarda bu kesimlerin, özel eğitim ve bakımlarla tedavi edildikleri bilinmektedir. Tarihî belgeler çerçevesinde araştırdığımız bu çalışmada, Osmanlı devlet yönetiminde uygulanan önemli bir kısım bölgelerin dışında, özel olarak ele alınan Edirne yöresindeki inanç ve ibadet hürriyeti uygulamalarından ve devlet görevinde çalışan gayrimüslim Osmanlı vatandaşlarından örnekler verilecektir. Örnekler, resmî devlet kayıtlarının yazıldığı 1312 ve 1316 hicrî tarihli, dönemin salnameleri ve Osmanlı Arşivi’nden alınan bir kısım belge örnekleri ile sunulmaya çalışılacak ve Osmanlı Devleti yönetim anlayışında, dinî ve kültürel farklılıklardan dolayı ayırımcılık yapılmadığı, belgeler çerçevesinde değerlendirilecektir.
Program metode latihan drill: Apakah Kemampuan Passing Siswa Dapat Meningkat?
Authors: Nur Hakim Muhamad Reza , Ismaya Bambang , Achmad Irfan Zinat
Published: October 2022

Masih rendahnya kemampuan siswa dalam melakukan passing menjadi permaslahan utama dalam penelitian ini. Penelitian ini bertujuan untuk menguji efek dari program metode latihan drill terhadap kemampuan passing siswa dalam olahraga futsal. Metode penelitian yang digunakan bersifat pre-eksperimen dengan One group pretest-postest design. Populasi berasal dari siswa di SMA Negeri 1 Pagaden dan sampel di ambil dari siswa yang mengikuti kegiatan ekstrakurikuler futsal (N=20). Instrumen untuk mengukur keterampilan passing siswa menggunakan tes passing ke tembok selama 30 detik. Analisis data dalam penelitian ini menggunakan IBM SPSS 25.0 untuk mencari nilai mean, standar deviasi, normalitas dan homogenitas. Paired sample t-test digunakan untuk menguji perbedaan nilai passing pada pre-test dan post-test. Hasil temuan utama dalam penelitian ini menunjukan bahwa program metode latihan drill secara signifikan dapat meningkatkan kemampuan passing siswa menjadi lebih baik (Sig<0.05). Dengan dmeikian penelitian ini telah membuktikan bahwa metode latihan drill efektif untuk meningkatkan kemampuan passing siswa dalam olahraga futsal
Hodnocení způsobilosti světových standardů projektového managementu pro řízení vývojových aktivit dodavatelů automobilového průmyslu
Authors: Knapp Filip
Published: October 2022

Článek pojednává o využití obecných standardů projektového managementu pro řízení vývojových aktivit dodavatelských společností automobilového průmyslu. V první části je uvedena základní charakteristika třech nejpopulárnějších světových standardů projektového managementu. V navazující části jsou standardy podrobeny hodnocení a uvedeno je doporučení vycházející z výsledků hodnocení a z charakteristiky jednotlivých standardů. Závěrečná část shrnuje výsledky hodnocení, obhajuje výsledná doporučení a nabádá k doplnění obecných standardů o oborové nástroje a metody projektového managementu, které vhodně doplní slabé stránky obecných standardů.
Development of logistics services of international transportation in the Kyrgyz Republic: theoretical and methodological aspects
Authors: Amankulov M. A. , Ajekbarov К. А. , Kamchybekov Т. К.
Published: October 2022

The paper considers the theoretical and methodological foundations of the development of logistics services based on the ratings of international organizations. The concepts of «logistics service» and «transportation service» are separated. The main characteristics of the logistics service are defined. The level and quality of logistics services in the Kyrgyz Republic is determined by the «immaturity» of logistics institutions and public administration.
Preservice teachers’ opinion about developing computational thinking in preschool
Authors:   Babes-Bolyai University (Romania), Bálint-Svella Éva , Zsoldos-Marchiș Iuliana ,   Babes-Bolyai University (Romania)
Published: October 2022

"Computational thinking is important not only for the study of some disciplines, but also in everyday life. Research show that this competency should be developed starting from preschool. The research presented in this paper aimed to study Primary and Preschool Pedagogy specialization students’ opinion and experience about including technological knowledge in preschool activities, emphasizing on developing computational thinking. The results show that even if the respondents consider that the preschool activities can develop a positive attitude towards technological knowledge, they don’t consider teaching the technology domain important in preschool and they have no experience with this. They have selected lack of methodological preparation and lack of necessary didactical tools as the main barriers in integrating technological knowledge in preschool activities. Only few respondents have a deeper insight into algorithms and one third of the respondents could give a correct algorithm for building a snowman. Respondents consider important to develop computational thinking in preschool using screen-free activities. One of the main methods to develop CT in preschool is using robots, but none of the participating students used a robot in their activities and only less than one fourth of the participants heard about educational robots."
Warunki blanszowania a wybrane właściwości fizyczne żółtej fasoli szparagowej przeznaczonej do mrożenia
Authors: Domin Marek , Kluza Franciszek
Published: October 2022

Badano możliwe interakcje pomiędzy wstępną technologią obróbki fasoli szparagowej a metodą jej zamrażania, celem uzyskania produktu przydatnego do składowania zamrażalniczego, oceniając zróżnicowane warunki blanszowania wodnego, zamrażania, składowania chłodniczego i jako fasoli po rozmrożeniu. Przedmiotem badań były karłowe żółtostrąkowe odmiany fasoli (Laura, Tara) oraz żółta odmiana tyczna (Atlas, typ Mamut). Badany materiał blanszowano przez 30, 60, 90 i 120 s w wodzie o temperaturze 60, 80 i 100°C, z dodatkiem 1%, 2%, 5% NaCl lub 1%, 2% CaCl2 i zamrażano (do -20°C) w powietrzu o temperaturze -35°C. Zamrożony materiał pakowano w polietylenowe woreczki, zamykano i przechowywano w temperaturze -30°C przez 6 miesięcy. Co 14 dni część prób rozmrażano i poddawano ocenie organoleptycznej. Stwierdzono, że wydłużanie czasu blanszowania w temperaturze 100°C zwiększało wyciek rozmrażalniczy, który w skrajnym przypadku osignął 18% masy próbki przed zamrożeniem. Blanszowanie w wodnych roztworach NaCl lub CaCl2 zmienia temperaturę krioskopową zamrażanej fasoli. W ocenie sensorycznej stwierdzono, że próbki nie blanszowane ulegały zwiększonym zmianom struktury odbieranym we wzroście odczucia włóknistości.
Symulacja komputerowa systemu filtracji
Authors: Tomasik Marcin
Published: October 2022

Przedstawiono symulację komputerową modelu systemu filtracji membranowej emulsji chłodząco-smarującej wykonaną w programie Matlab®. Symulacja komputerowa pozwala na logiczną weryfikację modelu przed wdrożeniem go do procesu technologicznego. Model wykonano w postaci struktury bloków funkcyjnych. Na wejście wprowadzano za pomocą mechanizmu dynamicznej wymiany danych wyniki pomiarów empirycznych. Taka forma weryfikacji pozwala na zbadanie wrażliwości modelu na zakłócenia oraz przetestowanie możliwoci obliczeniowych przed zaprogramowaniem sterowania za pomocą sterownika mikroprocesorowego.
Ocena właściwości trakcyjnych opon na wybranych drogach leśnych
Authors: Białczyk Włodzimierz , Cudzik Anna , Czarnecki Jarosław , Pieczarka Krzysztof
Published: October 2022

W pracy przedstawiono wyniki badań właściwości trakcyjnych wybranych opon na drogach leśnych. Badaniami objęto drogi leśne w odmiennych drzewostanach o nawierzchni gruntowej oraz drogi utwardzane żużlem i tłuczniem. Stwierdzono, że największe siły trakcyjne spośród badanych opon napędowych generowała opona 5.00-10 na nawierzchni tłuczniowej (604 N). Wród opon typu grass największe siły trakcyjne zanotowano dla opony 18×9.5-8 również na drodze o nawierzchni tłuczniowej (563 N). Najskuteczniejszym sposobem poprawy zdolności ciągowych było dociążanie badanych kół. Wyższe wartości współczynnika przyczepności zanotowano dla opon napędowych w porównaniu do opon typu grass. Wartości tego parametru zależne były od rodzaju drogi. Stosowanie modyfikacji badanych kół powodowało wzrost sił trakcyjnych oraz współczynnika przyczepności. Największą sprawność osiągnęły opony modyfikowane na drodze żużlowej. Dla opony 5.00-10 sprawność wynosiła 82%, a 75% dla opony 18×9.5-8.
Zastosowanie liniowego wskaźnika w ocenie odporności lemieszy płużnych na zużycie
Authors: Kostencki Piotr
Published: October 2022

Przy konstrukcyjnej różnorodności lemieszy płużnych aktualnie brak jest wiarygodnych wskaźników porównywania ich odporności na zużycie. Wykazano, że wyniki oceny z zastosowaniem parametru utworzonego na bazie zmiany obrysu i trwałości lemieszy są dokładniejsze niż uzyskiwane przy zastosowaniu jednostkowego masowego zużycia, tj. wskaźnika uwzględniającego ubytek masy i trwałość lemieszy. Stwierdzono, że efekt oceny odporności ściernej lemieszy z zastosowaniem wymienionych wskaźników może różnić się nawet 1,8-krotnie. Przyczyną jest różny proces zużywania się lemieszy, w zależności od warunków ich pracy i cech konstrukcyjnych, wpływający na różnice w bezwzględnym masowym zużyciu lemieszy.
Oświetlenie sztuczne przestrzeni w budynku inwentarskim w różnych stanach użytkowania lamp i wewnętrznych powierzchni obudowy
Authors: Żelazny Henryk
Published: October 2022

Oświetlenie sztuczne pomieszczeń oprócz umożliwiania łatwego i bezpiecznego wykonywania czynności powinno by racjonalne, w szczególności możliwie mało energochłonne. W badaniach porównawczych oceniano luksomierzem zróżnicowanie natężenia oświetlenia pod lampami o różnym stanie zabrudzenia oprawy i innym okresie użytkowania świetlówki oraz wpływ czyszczenia „na mokro” wykładziny z folii aluminiowej na poprawę oświetlenia ogólnego w pomieszczeniu inwentarskim. Różnica średniej wartości natężenia oświetlenia sztucznego między lampami o najmniejszej i największej skuteczności wynosiła aż 15,7%. Po zmywaniu kolejnych przegród wykończonych od wnętrza ekranami odbijającymi promienie świetlne obserwowano stopniowe spadki średniego natężenia oświetlenia sztucznego w pomieszczeniu inwentarskim od wartości 155,4 Lx do 151,1 Lx. Aby utrzymać prawidłowy fotoklimat we wnętrzu inwentarskim oświetlanym świetlówkami należy utrzymywać w czystości oprawy oraz wymieniać lampy jeszcze przed ich całkowitym zużyciem, do czego sygnałem może być zauważenie ciemnego pierścienia na końcach rur. Z kolei usuwanie zabrudzenia folii aluminiowych substancjami organicznymi za pomocą detergentów metodą „na mokro” nie prowadzi do korzystnych zmian w oświetleniu i należałoby podjąć badania nad skutecznością poprawy jasności przy czyszczeniu tego typu wykładziny „na sucho” lub z zastosowaniem innych technik.
Wpływ impregnacji próżniowej na energię i zdolność kiełkowania ziarna żyta
Authors: Rydzak Leszek , Andrejko Dariusz
Published: October 2022

W pracy podjęto próbę oceny wpływu impregnacji próżniowej ziarna żyta, realizowanej różnymi sposobami na jego żywotność. Ziarno impregnowano w komorze próżniowej, w ciśnieniu 5 kPa, stosując cztery różne warianty obróbki. Przeprowadzono również impregnację żyta w ciśnieniu 100 kPa (ciśnienie atmosferyczne – próba kontrolna). Pozostałe parametry procesu, tj. temperatura i czas kontaktu ziarna z czynnikiem impregnującym utrzymywano na stałym poziomie niezależnie od wariantu obróbki. Po procesie impregnacji badano zdolność i energię kiełkowania ziarna, jako miarę jego żywotności.Uzyskane rezultaty poddano analizie statystycznej, która potwierdziła, że impregnacja próżniowa nie wpływa istotnie na żywotność ziarna.