bluuebunny/crossref_metadata_2025 huggingface dataset:
Peran Relawan Politik Dalam Konstelasi Politik Indonesia
Authors: Syauket Amalia
Published: April 2022

Pemilihan Umum langsung merupakan pilar pertama dalam ber Demokrasi di Indonesia , dengan menganut  sistem one man, one vote dimana mengharuskan siapapun yang menginginkan kursi politik  dipemerintahan harus mendapat suara pemilih terbanyak. Kehadiran relawan menjadi penting bagi massa yang mendukung salah satu calon baik di Pilkada maupun Pilpres. Fenomena kemunculan deklarasi relawan ini mulai bermunculan setidaknya bisa kita lihat dari berbagai pemberitaan dimedia massa dan media sosial. Kehadiran relawan politik sebagai manifestasi dari meningkatnya partisipasi aktif warga masyarakat dalam berdemokrasi substantial.Relawan politik yang bergerak secara offline maupun online mampu meningkatkan partisipasi masyarakat yang menjadi kunci kehadiran model pemerintahan demokrasi ekstra parlementer.  Dengan menggunakan pendekatan kualitatif-deskriptif, peneliti bermaksud menggambarkan bagaimana peran relawan politik dalam konstelasi politik Indonesia.  Hasil penelitian ini  menunjukkan Fenomena relawan politik  Dalam Konstelasi Politik Indonesia  seolah-olah telah menjadi pilar utama pelembagaan demokrasi dengan caranya masing-masing bergerak sendiri untuk mendukung candidat masing-masing sehingga  dapat menjadi titik  awal dari dinamika transformasi nilai-nilai politis yang bernuasa patrimonial, oligarkis menuju volunterisme dan partisipatoris.
Laku Pandai Perbankan dan Perlindungan Nasabah: Studi Kasus Laku Pandai BCA di Kabupaten Demak Jawa Tengah
Authors: Faiz Kurniawan Muhammad
Published: April 2022

Bank memiliki peranan penting sebagai Lembaga intermediasi. Fungsi ini adalah menyalurkan dana dari orang yang berlebih keuangannya kepada msyarakat lain yang membutuhkan dalam bentuk kredit. Seiring dengan perkembangkan perbankan yang mengarah kepada branchless banking, yaitu bank nirkantor, maka proses penetrasi kepada masyarakat dan literasi keuangan dapat semakin ditingkatkan. Hal ini dikarenakan bank dapat menjangkau lapisan masyarakat paling dalam tanpa perlu membangun kantor cabang. Laku pandai menjadi agen utama bank untuk mencapai masyarakat paling dalam sekalipun. Dengan penelitian yuridis-normatif dengan menganalisa peraturan perundang-undangan dan wawancara kepada agen laku pandai di Kabupaten Demak ditemukan bahwa perbankan memiliki cukup instrument untuk melindungi nasabahnya terhadap laku pandai. Pengaturan oleh OJK juga dirasa cukup untuk pelaksanaan agen laku pandai dan perlindungan kepada nasabah. Laku pandai sebagai layanan perbankan tanpa kantor dengan memanfaatkan agen yang mana dikerjasamakan dengan pihak lain dan pemanfaatan tekhnologi informasi terbukti memberikan manfaat layanan dan perlindungan baik dalam kerahasiaan, keamanan simpanan kepada nasabah secara penuh.
Penyelesaian Ganti Kerugian Dalam Perkara Pidana Berdasarkan Penetapan Praperadilan: Studi Di Pengadilan Negeri Jakarta Selatan
Authors: Amin Rahman , Iren Manalu  , Winda Apricilya Van Hemert  , Muh Fikri Al Aziz
Published: April 2022

Negara hukum Indonesia berarti segala hal dalam penyelenggaraan pemerintahan termasuk proses penegakan hukum dilaksanakan sesuai ketentuan hukum yang berlaku dan terhadap tindakan penangkapan, penahanan, penuntutan serta peradilan terhadap seseorang yang tidak berdasarkan hukum, kesalahan terhadap orang, atau dalam penerapan hukumnya, maka orang tersebut berhak memperoleh ganti rugi guna memberikan keadilan. Penelitian ini adalah penelitian hukum yuridis normatif, dengan pendekatan perundang-undangan, dimana bahan hukum diperoleh melalui studi kepustakaan. Hasil penelitian menunjukan bahwa penyelesaian ganti kerugian berdasarkan penetapan praperadilan tidak dapat dilaksanakan oleh Kementerian Keuangan karena belum ada Peraturan Menteri Keuangan sebagai ketentuan pelaksanaan pembayaran ganti kerugian.  Faktor penghambat penyelesaian ganti kerugian yaitu faktor substansi hukum yakni Keputusan Menteri Keuangan tentang ganti rugi tidak relevan dengan keadaan saat ini tetapi belum diubah, faktor perbedaan persepsi tentang pihak yang bertanggungjawab dalam penyelesaian ganti kerugian, dan faktor tidak tersedianya anggaran secara khusus dialokasikan untuk penyelesaian ganti kerugian.
5-Aminolevulinic acid–enhanced fluorescence-guided treatment of high-grade glioma using angled endoscopic blue light visualization: technical case series with preliminary follow-up
Authors: Strickland Ben A. , Wedemeyer Michelle , Ruzevick Jacob , Micko Alexander , Shahrestani Shane , Daneshmand Siamak , Shiroishi Mark S. , Hwang Darryl H. , Attenello Frank , Chen Thomas , Zada Gabriel
Published: April 2022

OBJECTIVE

5-Aminolevulinic acid (5-ALA)–enhanced fluorescence-guided resection of high-grade glioma (HGG) using microscopic blue light visualization offers the ability to improve extent of resection (EOR); however, few descriptions of HGG resection performed using endoscopic blue light visualization are currently available. In this report, the authors sought to describe their surgical experience and patient outcomes of 5-ALA–enhanced fluorescence-guided resection of HGG using primary or adjunctive endoscopic blue light visualization.

METHODS

The authors performed a retrospective review of prospectively collected data from 30 consecutive patients who underwent 5-ALA–enhanced fluorescence-guided biopsy or resection of newly diagnosed HGG was performed. Patient demographic data, tumor characteristics, surgical technique, EOR, tumor fluorescence patterns, and progression-free survival were recorded.

RESULTS

In total, 30 newly diagnosed HGG patients were included for analysis. The endoscope was utilized for direct 5-ALA–guided port-based biopsy (n = 9), microscopic to endoscopic (M2E; n = 18) resection, or exoscopic to endoscopic (E2E; n = 3) resection. All endoscopic biopsies of fluorescent tissue were diagnostic. 5-ALA–enhanced tumor fluorescence was visible in all glioblastoma cases, but only in 50% of anaplastic astrocytoma cases and no anaplastic oligodendroglioma cases. Gross-total resection (GTR) was achieved in 10 patients in whom complete resection was considered safe, with 11 patients undergoing subtotal resection. In all cases, endoscopic fluorescence was more avid than microscopic fluorescence. The endoscope offered the ability to diagnose and resect additional tumor not visualized by the microscope in 83.3% (n = 10/12) of glioblastoma cases, driven by angled lenses and increased fluorescence facilitated by light source delivery within the cavity. Mean volumetric EOR was 90.7% in all resection patients and 98.8% in patients undergoing planned GTR. No complications were attributable to 5-ALA or blue light endoscopy.

CONCLUSIONS

The blue light endoscope is a viable primary or adjunctive visualization platform for optimization of 5-ALA–enhanced HGG fluorescence. Implementation of the blue light endoscope to guide resection of HGG glioma is feasible and ergonomically favorable, with a potential advantage of enabling increased detection of tumor fluorescence in deep surgical cavities compared to the microscope.
Cervical cerebrospinal fluid venous fistula with syringomyelia treated with suboccipital decompression: illustrative case
Authors: Hsieh Chia-Jung , Kuo Lu-Ting , Lai Dar-Ming , Huang Abel Po-Hao
Published: April 2022

BACKGROUND

Cerebrospinal fluid (CSF) venous fistulas are a recently discovered and underdiagnosed cause of spontaneous spinal CSF leak, which may lead to spontaneous intracranial hypotension. Most cases occur in the thoracic spine, and only 2 cases were reported in the cervical spine. Treatments include the epidural blood patch, fibrin glue injection, and surgical ligation of the fistula.

OBSERVATIONS

The authors report the treatment of a C6–7 CSF venous fistula, for which direct ligation was not feasible, with suboccipital decompression, leading to the complete resolution of the symptoms. Based on the clinical course and outcome in our patient, the authors summarize the previous theory and propose a hypothesis for the pathophysiology of headache and other symptoms in patients with CSF venous fistulas.

LESSONS

The symptoms of CSF venous fistulas may be linked not only to intracranial hypotension but also to the altered CSF dynamics induced by tonsillar herniation. Suboccipital decompression should be considered as a potential treatment option, especially in patients with Valsalva-induced headache who show a poor response to surgical ligation, patients in whom surgical ligation is not feasible, and patients with foramen magnum obstruction. Further investigation of the pathophysiology of CSF venous fistulas is warranted and should be performed in the future.
PulseRider-assisted embolization of a distal anterior cerebral artery bifurcation aneurysm: illustrative case
Authors: Dang Huy , Cotton Patrick , Lazaro Tyler , Khan A. Basit , Hoang Alex N. , Tanweer Omar , Raper Daniel M. S.
Published: April 2022

BACKGROUND

PulseRider is an endovascular device that can be a useful adjunctive device for wide-necked bifurcation aneurysms. However, its use in distal vessels such as the anterior cerebral artery (ACA) has not been widely reported.

OBSERVATIONS

The authors reported the case of a 75-year-old woman who underwent coiling of a 6.9-mm distal ACA aneurysm with PulseRider assistance. Using a partially intraaneurysmal deployment technique, the wide-necked aneurysm was successfully embolized, resulting in Raymond-Roy class II occlusion without intra- or periprocedural complications.

LESSONS

This case illustrates a novel approach to treatment for wide-necked distal ACA aneurysms, which can be challenging to treat via traditional endovascular means. PulseRider can be safely used to treat distal ACA aneurysms with minimal residual aneurysm.
Balamuthia mandrillaris brain infection: a rare cause of a ring-enhancing central nervous system lesion. Illustrative case
Authors: Levinson Simon , Kumar Kevin K. , Wang Hannah , Tayyar Ralph , Dunning Megan , Toland Angus , Budvytiene Indre , Vogel Hannes , Chang Amy , Banaei Niaz , Shuer Lawrence
Published: April 2022

BACKGROUND

An 80-year-old man presented with subacute mental status change, dizziness, and left-sided vision loss. Magnetic resonance imaging demonstrated a ring-enhancing right parietooccipital lesion.

OBSERVATIONS

Biopsy and laboratory testing demonstrated an amoebic Balamuthia mandrillaris infection. Fewer than 200 cases of this infection have been recognized in the United States, and no standardized treatment regimen currently exists.

LESSONS

Rapid antimicrobial therapy with miltefosine, azithromycin, fluconazole, flucytosine, sulfadiazine, and albendazole was initiated. The pathophysiology, diagnosis, and management of this infection and the patient’s course were reviewed. The importance of biopsy for pathologic and laboratory diagnosis and rapid treatment initiation with a multidisciplinary team was reinforced.
Arachnoid cyst alone causes hemifacial spasm: illustrative case
Authors: Ozaki Ko , Higuchi Yoshinori , Nakano Shigeki , Horiguchi Kentaro , Yamakami Iwao , Iwadate Yasuo
Published: April 2022

BACKGROUND

Hemifacial spasm (HFS) due to an arachnoid cyst at the cerebellopontine angle is rare. Here, the authors reported such a case and analyzed the mechanism of facial nerve hyperactivity by reviewing the literature.

OBSERVATIONS

A 40-year-old man presented with right HFS for the past 3 years. Preoperative magnetic resonance imaging revealed a right cerebellopontine angle cystic mass with high intensity on T2-weighted images, low intensity on T1-weighted and diffusion-weighted images, and no contrast effects. Cyst excision and decompression of the facial nerve using a lateral suboccipital approach to monitor abnormal muscle response (AMR) resulted in permanent relief. The cyst was histologically compatible with an arachnoid cyst.

LESSONS

In the present case, when the cyst was dissected, the AMR disappeared and no offending arteries were detected around the root exit zone. Therefore, the cyst itself was responsible for HFS, for which AMR was useful. Limited cases of HFS due to arachnoid cysts without neurovascular compression have been previously reported. The authors suggested that pulsatile compression by the cyst results in facial nerve hyperactivity and secondary HFS.
Combined C1–2 transarticular screw fixation and C1 laminoplasty with interlaminar bone transplant for retro-odontoid pseudotumor: illustrative case
Authors: Fukunaga Takanori , Yonenobu Kazuo , Sasaki Manabu , Kishima Haruhiko
Published: April 2022

BACKGROUND

The surgical treatment for retro-odontoid pseudotumor (ROP) remains controversial. Posterior C1 laminectomy without fixation occasionally leads to postoperative enlargement of ROP. Because its pathogenesis is associated with atlantoaxial instability, atlantoaxial fixation with C1 laminectomy is commonly performed. Atlantoaxial fixation usually includes transarticular fixation and screw-rod fixation. However, these methods have some issues. That is, in transarticular fixation with C1 laminectomy, the bone grafting area is challenging to obtain. In screw-rod fixation with C1 laminectomy, extensive bleeding occurs at times if the lateral atlantoaxial joint is exposed to the transplant bone grafts.

OBSERVATIONS

Herein, the authors report a case of ROP treated with combined C1–2 transarticular screw fixation and C1 laminoplasty with interlaminar bone transplant, which can help achieve adequate spinal cord decompression and can simultaneously secure the bone grafting area between the laminae. In addition, the volume of intraoperative blood loss decreased. Postoperative magnetic resonance imaging showed sufficient decompression of the spinal cord at the C1 level, and computed tomography performed after 6 months revealed bone union between the C1 and C2 laminae.

LESSONS

Combined C1–2 transarticular screw fixation and C1 laminoplasty with interlaminar bone transplant is a useful method for ROP.
Основи культури і техніки мовлення
Authors: Кравцова І. А. , Шпачук Л. Р.
Published: April 2022

Курсом «Основи культури і техніки мовлення» передбачено актуалізацію і поглиблення знань першокурсників з української мови, формування на їх основі загальної мовної та мовленнєвої культури, оволодіння основами теорії і практики мистецтва слова, виразного читання. У посібнику з урахуванням науково-методичних здобутків минулого і сьогодення запропоновано теоретичні та практичні матеріали, завдання для самостійної та індивідуально-творчої роботи, покликані систематизувати належне засвоєння першокурсниками основних відомостей з курсу. Посібник укладений на допомогу студентам вищих навчальних закладів.
Основи педагогічної психології
Authors: Токарева Наталя Миколаївна
Published: April 2022

У посібнику викладено основні теоретичні положення педагогічної психології як навчальної дисципліни: психологічні особливості учбової діяльності, навчання, виховання та педагогічної діяльності. Теоретико-інформаційний блок посібника доповнюють методичні рекомендації, які носять практико-орієнтовний характер: вони містять плани практично-семінарських занять до вивчення тем із педагогічної психології (питання для підготовки та дискусії), психологічні завдання, тести для самоперевірки, що сприяє систематизації знань при підготовці студентів до занять, полегшує пошук матеріалу і визначає структуру семінарських занять при вивченні педагогічної психології. Структура посібника відповідає вимогам до викладання у вищих навчальних закладах у контексті кредитно-модульної системи організації навчального процесу.
Агрофітоценологія: аспекти теорії, методології та суміжних наук
Authors: Шанда В. І. , Євтушенко Е. О. , Ворошилова Н. В. , Маленко Я. В.
Published: April 2022

Монографія окреслює широку проблематику агрофітоценології, що є визначальною складовою культурфітоценології. У ретро- та перспективі висвітлюються сутність, розвиток, міждисциплінарні зв’язки, онтологічні, гносеологічні та теоретичні проблеми, концепції, диференційованість агрофітоценології як науки. Наведено системне бачення та елементно-структурний аналіз агрофітоценозів, їхнє членування. Агрофітоценологія пов’язується з агробіогеоценологією, агроекологією, її аут- і синекологічними підходами, з еколого-еволюційними аспектами адаптивних землеробства та рослинництва, розвиваються ідеї адаптаціоґенезу та теорії екологічної ніші.
Об’ємний метод хімічного аналізу
Authors: Нечипуренко Павло Павлович , Шенаєва Тетяна Олексіївна
Published: April 2022

Спецвипуск «Методичний посібник у журналі» містить посібник П. П. Нечипуренка та Т. О. Шенаєвої з виконання лабораторних робіт з об’ємного методу кількісного хімічного аналізу. У посібнику наведено основні теоретичні відомості про сутність методів титриметричного аналізу, їх особливості та межі застосування; відібрано окремі методики проведення титриметричного аналізу різними методами та детально описано усі етапи їх здійснення. Для студентів хімічних спеціальностей педагогічних ВНЗ, учителів та учнів профільних класів та класів з поглибленим вивченням хімії.
Методичні рекомендації до проведення навчально-польової практики з систематики рослин для студентів спеціальності 014.05 Середня освіта (Біологія та здоров’я людини)
Authors: Кобрюшко Олександр Олексійович , Перерва Вікторія Вікторівна
Published: April 2022

Методичні рекомендації до польової практики з дисциплін «Ботаніка з основами геоботаніки (систематика рослин)» є нормативним документом Криворізького державного педагогічного університету, який розроблено кафедрою ботаніки та екології на основі освітньо-професійної програми підготовки бакалаврів відповідно до навчального плану для спеціальності 014 Середня освіта (Біологія та здоров’я людини) денної форми навчання.
Управління школою
Authors: Пікельна В. С.
Published: April 2022

У книзі розглядаються основні напрями управлінської діяльності керівників шкіл і будь-якої структурної ланки в загальній ієрархії управління школою (загальноосвітньою, вищою). Автор розкриває зміст технологічних функцій, форми та методи управління школою, надає особливу увагу організаційно-розпоряджувальному моделюванню. Посібник адресовано керівникам навчальних закладів, педагогам-практикам, викладачам і студентам педагогічних ВНЗ у системі безперервної освіти і всім організаторам педагогічної діяльності.
THE ACTIVITY OF MOLYBDENE-VANADIUM OXIDE CATALYSTS IN THE
ISOPROPYL ALCOHOL CONVERSION REACTION
Authors: Dushdurova Nurlana
Published: April 2022

The activity of molybdenum-vanadium oxide catalysts in the conversion of isopropyl alcohol has been studied. It was found that acetone and propylene are the main products of the isopropyl alcohol conversion reaction. Studies have shown that the activity of binary molybdenumvanadium oxide catalysts depends both on the reaction conditions and on the atomic ratio of molybdenum to vanadium. It has been shown that molybdenum-vanadium oxide catalysts have a sufficiently high activity in the reaction of propylene and acetone formation and can be used for further modification in order to increase their catalytic activity.
Keywords: isopropyl alcohol, acetone, propylene, binary catalysts, molybdenum oxide, vanadium oxide.
Safety of electromagnetic factors for the workplace equipped with personal computers in residential premises
Authors: Ryabov Yu. G. , Legkiy N. M. , Lomaev G. V.
Published: April 2022

Objectives. The aim of this paper is to analyze the electromagnetic safety of 50Hz industrial frequency electrical networks in residential buildings when using workplaces equipped with personal computers (PCs), as well as to develop recommendations on reducing the impact of levels of industrial frequency electromagnetic fields on human health in residential premises.Methods. Electromagnetic fields in residential premises with the single-phase TN mode industrial frequency power supply system regulated by the Rules of Electrical Installations Design were measured and calculated in accordance with Russian and international legislative documents.Results. It was established that electromagnetic fields induced by TN networks in workplaces equipped with PCs might increase significantly and even exceed the maximum permissible level of 25 V/m and 0.25 μT recommended by Sanitary and Epidemiological Standards. Residential buildings are not subject to the requirements of the Energy Supervision services; therefore, any unprofessional modification of electrical networks in residential premises, including the use of unapproved extension cords, may result in sparking, high-frequency harmonics, and, in turn, conditions which impact human health, as well as electric injures, fires, and gas explosions.Conclusions. It has been shown that IT (TT) mode symmetrical two-phase electrical networks may function efficiently for decades without accidents and effects of industrial frequency electromagnetic field on humans, as they are used in medical institutions, defense enterprises, and state institutions. Thus, legislative transition to installing IT (TT) systems in residential buildings, replacement of existing TN power supply systems with IT (TT) system, and legislative strengthening of requirements for household protection and commutation devices, may also be required to reduce man-made disaster risks in residential buildings.
Application of an integrated method to improve the quality of manufacturing parts of electronic warfare devices
Authors: Kryukov A. V.
Published: April 2022

Objectives. The development of technological methods with the purpose of increasing the structural strength of defense engineering products can be carried out by creating new methods for obtaining and processing parts or improving traditional methods based on an integrated (synergistic) approach. The article presents a complex method for surface treatment of parts and assessment of the hardness and surface roughness of the initial workpiece from alloys of the Al–Mg system to improve the quality of manufacturing the module cases of the MSP-418K product related to electronic warfare devices.Methods. This approach consists in the vision of a metallic material as a system subjected to a chain of technological impacts in the process of chemical, thermodynamic, and mechanical interaction of its components. The workpieces were obtained by metal pressure treatment according to various schemes and temperature conditions Then they were processed with a blade tool using a dynamometer. The resulting cut was examined using a metallographic method along the entire end face from the outer surface to the center of the sample of workpieces.Results. Experiments were carried out for the case of Al–Mg alloys. It made it possible to reveal the relationship between the parameters of the change in the structure of the material being processed and the stability of the cutting process, as well as the quality of the surface during finishing turning.Conclusions. The proposed technological solutions based on a synergistic approach provided a balanced improvement in material parameters by eliminating the shortcomings of the original semi-finished product. The obtained experimental data allowed concluding the deformation of workpieces according to complex schemes at low temperature has a beneficial effect on the machinability of the metal material, ordering the structure and improving the quality of the surface of the parts. Using a synergistic approach, it became possible to correct the poor technological heredity of material properties obtained in previous operations: the surface quality of the workpieces due to the continuity of the processed material and the strength properties of parts for critical and especially critical purposes were improved. The existing technological process for manufacturing the “petal” part was changed in practice using an integrated method, which made it possible to improve its technological and technical characteristics.
Semantics of visual models in space research
Authors: Savinykh V. P. , Gospodinov S. G. , Kudzh S. A. , Tsvetkov V. Ya. , Deshko I. P.
Published: April 2022

Objectives. The aim of the study is to develop a methodology for assessing the semantics of weakly structured or morphologically complex visual information models. In order to achieve the goal, a criterion for classifying visual models as complex and an algorithm for obtaining a gradient image with several levels of density were introduced. The gradient image is not binary, thus increasing the reliability of finding boundaries or contours. An auxiliary structural visual model was introduced, and a series of images of different densities was used in processing. Next, the concept of a conditional image coordinate system was introduced. This allows for information to be transferred from different visual models to a synthetic resulting visual model.Methods. Using gradient image processing and constructing a new intermediate structural model allows models with different densities to be linked. A system of conditional image coordinates was introduced and a series of models with different densities to obtain a synthetic image was processed.Results. The visual models obtained from satellite images with poor visibility of objects were processed in the Sun– Earth–Moon system. The Sun–Earth system was chosen as the basis. A characteristic of space images is the fact that the bright light of the Sun “clogs” the images of other objects with large phase angles. The use of the contouring technique allows for the visibility of images of low brightness and high brightness to be equalised. The shift of the frequency response after detection of all objects enabled the formation of a clear visual model.Conclusions. In primary visual models, low brightness images were not visible. They appeared when exposure was increased, while high-density objects merged into one. Because of this, it is fundamentally impossible to obtain a high-quality image of all objects, or the complete semantics of a visual model from a single high, medium, or lowdensity image. In order to obtain the complete semantics of the visual model, a series of images need to be processed with the transfer of images to a common synthetic image. The proposed technique allowed for such problems to be resolved. A comparison of the results obtained using the methods of processing a single image proved the reliability and high information content of the method.
Identification of knowledge sources for micro- and nanoelectronics technologies
Authors: Sharapov A. A. , Gornev E. S.
Published: April 2022

Objectives.Over the past few decades, multiple knowledge management models have been developed by many research groups studying the innovation process in companies. However, these knowledge and information management models are rather general, and do not consider the dynamics and variability of technology development. This implies involving specific organizations in different types of knowledge generation activities. The paper aims to reveal the importance of a knowledge management system in micro- and nanoelectronics technologies as well as identify and systematize the sources of knowledge in the scientific and technical field.Methods.In this paper, the method for analyzing the relationship between key business indicators of the companies is applied. The results are then represented in a causal loop diagram. The stakeholder analysis method is also used here.Results.Three relevant trends in developing the knowledge management system for knowledge-intensive enterprises involved in micro- and nanoelectronics technologies are identified with respect to the social, commercial, and scientific and technical aspects in research organizations. The key sources of knowledge on micro- and nanoelectronics technologies include universities, institutions of the Russian Academy of Sciences, industry-specific institutions, customers, manufacturers, and consumers. Also, the authors consider digital twins to be a promising source of knowledge on micro- and nanoelectronics technologies.Conclusions.The analysis of the technology life cycle curve using the example of micro- and nanoelectronics allows correlating single stages of this life cycle with specific activities during which new knowledge is generated. These activities include fundamental and applied research, requirements management, implementation in manufacturing, and operation analysis. For microelectronics, they correspond to the areas of emergence, peak of inflated expectations, trough of disillusionment, slope of enlightenment, and plateau of productivity on the technology life cycle curve.
ACE inhibitors in a multimorbid patient: focus on fosinopril
Authors:   Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation, Fomin I.V.
Published: April 2022

Changes in the profile of risk factors, the neglect of simple preventive measures and the use of low doses of medication lead to the appearance of numerous multimorbid patients. Each practitioner faces this issue, both at the start of drug selection and during treatment. The more difficult a patient is, the more difficult it is to select medications of choice. This translates into polypharmacy and reduced therapeutic effectiveness. The basic rule of multimorbid patient treatment is the use of the most studied, safe and strategically efficient agents to improve hemodynamic parameters and quality of life. Meanwhile, the most important goal (sometimes overlooked) is to improve the prognosis at each stage of multimorbidity. ACE inhibitors in optimal dosages with a maximum safety profile are preferred drugs in multimorbid patients. According to the U.S. Ambulatory Guidelines (2019) and KDIGO 2021, of the ACE inhibitors used in daily practice, fosinopril is the safest medication in multimorbid patients. KEYWORDS: ACE inhibitors, fosinopril, multimorbid patients, treatment, congestive heart failure. FOR CITATION: Fomin I.V. ACE inhibitors in a multimorbid patient: focus on fosinopril. Russian Medical Inquiry. 2022;6(1):12–20 (in Russ.). DOI: 10.32364/2587-6821-2022-6-1-12-20
New look on the use of sodium escinate in patients with post-COVID conditions
Authors:   Russian University of Peoples’ Friendship, Moscow, Russian Federation, Shugushev Z.Kh. ,   Central Clinical Hospital RZD-Meditsina, Moscow, Russian Federation, Akulova A.A. ,   Central Clinical Hospital RZD-Meditsina, Moscow, Russian Federation
Published: April 2022

The emergence of the COVID-19 infection associated with multisystem disorders, long-term-complications (post-COVID conditions), low productivity and reduced quality of life, the lack of a unified treatment resulted to the search of novel agents and expansion of indication for use of pre-existing medications. Escine is an active ingredient of Aesculus hippocastanum (horse chestnut) which is well-known in the phlebological pharmaceutical market. This paper reviews recent pharmacological and clinical data on anti-edematous, anti-inflammatory, and antioxidant effects of sodium escinate in post-COVID conditions. The anti-inflammatory and antiviral effects of sodium escinate involve inhibiting the secretion of proinflammatory cytokines (including tumor necrosis factor a and interleukin 1β) by LPS-induced RAW264.7 macrophages. In Russia, escine is a component of a combined formulation based on horse chestnut seed extract and thiamine (vitamin B1). Given efficacy of sodium escinate (based on the results of in vitro and in vivo experimental studies) and its antiviral and anti-inflammatory properties, this agent can be prescribed for the COVID-19 complications. KEYWORDS: sodium escinate, post-COVID conditions, anti-inflammatory effects, phlebological agent, SARS-CoV-2. FOR CITATION: Shugushev Z.Kh., Akulova A.A. New look on the use of sodium escinate in patients with post-COVID conditions. Russian Medical Inquiry. 2022;6(1):33–38 (in Russ.). DOI: 10.32364/2587-6821-2022-6-1-33-38.
Optimal medical therapy for heart failure: eplerenon in a hospital setting (case report)
Authors:   Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation, Sedykh D.Yu. , Kashtalap V.V. ,   Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation, Barbarash O.L. ,   Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation
Published: April 2022

Heart failure (HF) is a major issue in the modern society. A growing number of users, re-hospitalizations due to decompensation and disability cause significant economic costs and a high workload for both in-patient and out-patient practitioners. This article highlights the practical importance of timely prescription of mineralocorticoid receptor antagonists (specifically, eplerenone, a selective drug) in inpatient and outpatient settings. The efficacy and tolerability of this drug are established through the results of large studies. Eplerenone is included in the clinical guidelines of the Ministry of Health of Russian Federation, national guidelines on acute heart failure of the Russian Cardiological Society and Russian Therapeutic Society guidelines on HF diagnosis and treatment. It is recommended for all patients with moderate and severe HF, irrespective of the origin and LV ejection fraction. The established safety of eplerenon allows for its use in multimorbid patients. This case report demonstrates the effects of bioequivalent eplerenone (Espiro) for stabilizing the condition after HF decompensation with a transient decrease in LV ejection fraction. KEYWORDS: heart failure, decompensation, mineralocorticoid receptor antagonists, eplerenon. FOR CITATION: Sedykh D.Yu., Kashtalap V.V., Barbarash O.L. Optimal medical therapy for heart failure: eplerenon in a hospital setting (case report). Russian Medical Inquiry. 2022;6(1):45–51 (in Russ.). DOI: 10.32364/2587-6821-2022-6-1-45-51.
Heart-type fatty acid binding protein: the promising biological marker in heart failure
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Aliyeva A.M. , Baykova I.E. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Reznik E.V. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Pinchuk T.V. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Shnakhova L.M. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Valiev R.K. ,   A.S. Loginov Moscow Clinical Research Center, Moscow, Russian Federation, Saryiev M.N. ,   A.S. Loginov Moscow Clinical Research Center, Moscow, Russian Federation, Rakhaev A.M. ,   Kh.M. Berbekov Kabardian-Balkar State University, Nalchik, Russian Federation, Nikitin I.G. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Kovtyukh I.V. ,   Central Clinical Hospital of the Russian Academy of Sciences, Moscow, Russian Federation
Published: April 2022

In recent decades, significant progress has been made in the study of cardiovascular biological markers. The introduction into clinical practice of studying the concentration of natriuretic peptides used as markers for the diagnostic and prognostic assessment of patients with chronic heart failure became the crucial event. At present, the assessment of the values concerning the ventricular natriuretic peptide and its N-terminal precursor is the gold standard in laboratory diagnosis of heart failure and predicting its course. However, there are limitations due to the influence of several factors on their indicators, the ambiguity of threshold values and rather low information content in heart failure with preserved ejection fraction. Even a special sub-study of the large-scale PROTECT protocol could not identify an ideal single biomarker among 48 different markers for prognostic evaluation of patients with acute heart failure. All this determines the need for further search for highly sensitive and more specific markers. This review is devoted to the study of the possibility of using heart-type fatty acid binding protein (H-FABP) as a diagnostic and prognostic biomarker in heart failure. To date, one of the possible applications of H-FABP may be in the diagnosis of the early stages of heart ischemia and inflammation. KEYWORDS: heart failure, biological marker, left ventricular ejection fraction, Heart-type fatty acid binding protein, troponin, natriuretic peptides. FOR CITATION: Aliyeva A.M., Baykova I.E., Reznik E.V. et al. Heart-type fatty acid binding protein: the promising biological marker in heart failure. Russian Medical Inquiry. 2022;6(1):5–11 (in Russ.). DOI: 10.32364/2587-6821-2022-6-1-5-11.
Consumo e parâmetros produtivos de ovelhas gestantes suplementadas com concentrado
Authors:   Universidade Federal de Lavras, Siqueira Marco Túlio Santos , Silva Adriana Lima ,   Universidade Federal de Uberlândia, Oliveira Karla Alves ,   Universidade Estadual Paulista, Schultz Erica Beatriz ,   Universidade Federal de Viçosa, Jesus Thauane Ariel Valadares de ,   Universidade Federal de Uberlândia, Macedo Júnior Gilberto de Lima ,   Universidade Federal de Uberlândia
Published: April 2022

The effect of concentrate supplementation on pregnancy and dry matter intake of ewes was evaluated. 41 animals were used, with 64.18 kg of average weight, distributed in a completely randomized design with repeated measures over time. The treatments consisted of two levels of concentrate. Analysis of variance and Tukey's test were performed at 5% of significance. There was an increase in consumption and body weight throughout the period. There was an effect of supplementation on placental weight, being superior in the treatment with 400g, and in multiple deliveries. Supplementation of pregnant ewes in the prepartum period improved BCS as well as birth weight of the lambs.
Expansão do ataque da broca peluda Hyponeuma taltula
Authors:   Universidade Federal do Espírito Santo, Pratissoli Dirceu , Carvalho Jovenildo ,   AgroSolver Consultoria e Assistência Técnica EIRELI, Pancieri Guilherme ,   Universidade Federal de Viçosa, Pratissoli Felipe S. M. ,   Universidade de São Paulo
Published: April 2022

Hyponeuma taltula, commonly known as the hairy borer, deserves to be highlighted due to its high potential for destruction, as well as the very little amount of ecological and entomological information and the lack of efficient control management so far.
Pentingnya Menjaga Kesehatan Gigi Dan Mulut Di Era Pandemi Covid'19, Demi Kelangsungan Aktivitas Usaha
Authors: Septiani Dewi , Sughesti Dewi , Susanti Diena , Sihombing Marya Tripena Polmauly , Novitasari Sela
Published: April 2022

Pengabdian Kepada Masyarakat ini berjudul Pelatihan SDM: Pentingnya Menjaga kesehatan Gigi dan Mulut di era Pandemi Covid 19 demi kelangsungan aktivitas usaha. Pengabdian ini bertujuan ini untuk memberikan penyuluhan berupa pengetahuan serta pelatihan kepada UMKM di Desa Situgadung. Permasalahan di tempat tersebut yaitu penurunan tingkat kesehatan masyarakat umumnya akibat pandemi dan juga terjadi penurunan kesehatan gigi dan mulut pada lingkungan masyarakat terutama lingkungan pelaku UMKM. Memberikan pelatihan kepada masyarakat terutama para pelaku UMKM untuk menjaga kesehatan gigi dan mulut guna untuk dapat terus beraktifitas melakukan penjualan karena dapat terhindar dari penyakit. Metode yang digunakan adalah metode survey dan penyampaian materi secara langsung serta simulasi dan diskusi mengenai kesehatan gigi dan mulut. Hasil dari kegiatan pengabdian kepada masyakat ini adalah perlunya mengadakan penyuluhan, pelatihan dan simulasi agar masyarakat lebih peduli dengan kesehatan dan kebersihan gigi dan mulut.
Sistem Portable Hybrid On-Grid PV-PLN-Generator Teraplikasi Di Desa Pemulutan
Authors: Sofijan Armin , Pradana Wirawan Adi , Cekdin Cekmas , Bizzy Irwin
Published: April 2022

Pemulutan village has a location that is separated by a small river, where only one of its locations has access to PLN electricity rom the government. The portable hybrid on grid system PV-PLN-Generator has the ability to combine a power source from PLN with alternative sources of electricity from solar panels and generators, this system was applied in this study by adding a portable system, so that it can be carried and moved easily from opposite locations of river. The ouput power of one solar panel is about 20-25 W, so it takes 6-7 solar panels to be used with load 70 Watt for 12 hours. The results of this research are very helpful for Pemulutan’s village, with the portable hybrid on grid (PHoG) system can help access electricity for lighting, process garden products, and relieve the cost of charging PLN electricity.
Antioxidant enzymes activity and membrane thermostability in durum wheat genotypes under heat stress
Authors: Zulfuqarova S. T. , Rustamova S. M. , Huseynova I. M.
Published: April 2022

Relevance. Insufficient tolerance to extremely high temperatures is one of the main reasons for the decline in crop yields.Methods. Two contrasting durum wheat genotypes (Triticum durum Desf.) were used in the present study: Barakatli 95 (tolerant genotype) and Garagylchyg 2 (stress-sensitive genotype). The activity of antioxidant enzymes, ascorbate peroxidase (APO), catalase (CAT), guaiacolperoxidase (GPO), and benzidine peroxidase (BPO), were studied spectrophotometrically. The membrane thermostability was determined by the release of electrolytes from intact plant tissue.Results. It was revealed that guaiacolperoxidase plays a key role in the elimination of reactive oxygen species when exposed to high temperatures, since a significant increase in the activity of this enzyme was observed during short-term thermal stress. Heat stress caused a slight decrease in catalase activity and a significant decrease in the activity of ascorbate peroxidase and benzidine peroxidase. An increase in total protein concentration was observed under heat stress. The indicators of the electrolyte leakage from leaf tissues confirm the variety-specific thermostability of wheat membranes. The membrane damage rate (MDR) increased in direct proportion to the heating temperature and showed the highest value in the sensitive Garagylchyg 2 variety. According to the electrolyte leackage parameters from leaf tissues during hyperthermia, was concluded variety-specific thermal stability of wheat plant membranes.
Estimation of the yield structure elements of the collection winter durum wheat samples in the south of the Rostov region
Authors: Ivanisova A. S.
Published: April 2022

Introduction and methodology. The value of the initial material is primarily determined by the tasks of modern breeding process, collection material playing an important role in it. The purpose of the current study was to estimate the initial material of winter durum wheat according to their yield structure elements in the south of the Rostov region. The objects of research were 159 winter durum wheat samples among which there were 69 of domestic breeding and 90 of foreign one.Results. The study has shown that in 2019–2020 grain productivity of the collection samples ranged from 227.9 g/m2 to 735.9 g/m2. All studied samples were divided into three groups according to the trait ‘productive stand’ (number of productive stems per 1 m2). There were 17.6% of samples with a small value of the trait (201–400 pcs./m2); with a mean value of the trait (401–600 pcs./m2) there were 72.3% of samples and with a large value of the trait (601–800 pcs./m2) there were 10.1% of samples. According to the trait ‘plant height’ more than a half of the samples (57.0%) belonged to the ‘semi-dwarf’ group (61–85 cm). Large part (70%) of winter durum wheat samples formed ‘length of head’ in the range of 6.5–7.5 cm. In 2019–2020, number of spikelets per head ranged from 17 pcs. up to 24 pcs. The trait ‘kernel weight per head’ of the studied collection samples varied from 0.77 g to 2.08 g, all the samples had different kernel sizes. The trait ‘number of kernels per head’ varied from 22 pcs. (the variety ‘Novinka 4’) up to 51 pcs. (the sample ‘1015/16’). The trait ‘1000-kernel weight’ in the trial ranged from 23.9 g to 49.0 g, the standard variety had 34.1 g. The productivity of the collection samples was formed due to 1000-kernel weight and kernel weight per head, the correlation coefficients for these productivity elements being r = 0.45 ± 0.07; r = 0.35 ± 0.07.
МАРКЕТИНГОВИЙ ОГЛЯД РИНКУ ЗЕЛЕННИХ КУЛЬТУР
Authors: Terokhina L. A. , Rud V. P. , Mozgovskiy O. F. , Ilyinova Y. M. , Leus L. L. , Sidora V. V.
Published: April 2022

Мета. Здійснити маркетинговий огляд ринку зеленних культур в Україні, проаналізувати канали продажу цього виду продукції, експертно-імпортні операції, встановити основні проблеми та визначити напрями підвищення ефективності у перспективі. Результати. Проведено маркетинговий аналіз ринку зеленних культур, проаналізовано експертно-імпортні операції та канали продажу цього виду продукції, ранжування і групування основних видів овочевих і баштанних культур в Україні запоказником валового виробництва. Наукова новизна полягає у тому, що для вивчення ставлення споживачів до зеленної овочевої продукції проведено соціологічне опитування та здійснено аналіз основних факторів, що впливають на купівлю цього виду продукції. З’ясовано, що при виборі торговельної точки великий вплив на споживчу поведінку мають такі фактори, як місце розташування, сервіс, якість обслуговування в місцях купівлі зеленної продукції, асортимент, кваліфікація персоналу та ін. Проаналізовано переваги і недоліки окремих каналів збуту зелені. До переваг слід віднести: зручність, територіальну близькість, широкий асортимент, гнучкість цін, якість продукції, її свіжість та ін. До недоліків відносять: відсутність сертифікатів на продук цію, звужений асортимент та незадовільні санітарні умови торгових місць. У статті встановлено основні проблеми та визначено пріоритетні напрями розвитку ринку зеленних культур на перспективу. Висновки. Маркетинговий огляд ринку зеленних культур показав, що даний сегмент овочевого ринку поки що знаходиться в зародковому стані. Вивчення споживацьких уподобань зеленної овочевої продукції дозволило встановити, що до найбільш важливих факторів впливу на купівлю зелені слід віднести наступні: якість, ціна, виробники, упаковка та ін. Повноцінне формування та функціонування зеленного овочевого ринку гальмується відсутністю маркетингової складової в системі обміну та потребує кардинальних перетворень. Крім того, необхідно змінювати підходи у свідомості громадян щодо стилю харчування шляхом проведення інформаційно-освітньої роботи та орієнтації українців на споживання зеленних овочевих культур та мікрогріну як невичерпного джерела фітонутрієнтів та антиоксидантів, особливо в умовах пандемічних загроз. Крім того, подальший розвиток ринку зелені в Україні необхідно направити по шляху організації високоінтенсивного виробництва на основі впровадження сучасних технологій, нових високопродуктивних сортів і гібридів. При цьому в перспективі необхідним є технічне переоснащення галузі овочівництва, розвиток систем інформаційного забезпечення, створення служб маркетингу й подальший розвиток інфраструктури ринку.