bluuebunny/crossref_metadata_2025 huggingface dataset:
Hepatic Infiltration with Malignant T-cells Manifesting as Impending Acute Liver failure in Mycosis Fungoides with Large Cell Transformation
Authors: Zhang Yumeng , Song Jinming , Rutenberg David , Sokol Lubomir
Published: January 2020

Here we described a patient with a history of mycosis fungoides who developed large cell transformation manifesting with generalized erythroderma, lymphocytosis, lymphadenopathy and impending acute liver failure (ALF). Three-phase computed tomography of the liver showed neither mass nor hepatomegaly. Liver biopsy confirmed infiltration with malignant CD4+ clonal T-cells. Combination chemotherapy with gemcitabine, dexamethasone, and cisplatin (GDP) resulted in the recovery of liver function and resolution of skin involvement. In Foundation Medicine Hematology Gene Panel, 31 genetic alterations with 11 clinically relevant mutations were identified including ARID2 mutation frequently observed in hepatocellular carcinoma but rarely observed in hematologic malignancies.
On the Linearity of Order-isomorphisms
Authors: Lemmens Bas , van Gaans Onno , van Imhoff Hendrik
Published: January 2020

A basic problem in the theory of partially ordered vector spaces is to characterise those cones on which every order-isomorphism is linear. We show that this is the case for every Archimedean cone that equals the inf-sup hull of the sum of its engaged extreme rays. This condition is milder than existing ones and is satisfied by, for example, the cone of positive operators in the space of bounded self-adjoint operators on a Hilbert space. We also give a general form of order-isomorphisms on the inf-sup hull of the sum of all extreme rays of the cone, which extends results of Artstein–Avidan and Slomka to infinite-dimensional partially ordered vector spaces, and prove the linearity of homogeneous order-isomorphisms in a variety of new settings.
Bottom-water temperature controls on biogenic silica dissolution and recycling in surficial deep-sea sediments
Authors: Varkouhi Shahab , Wells Jonathan
Published: January 2020

Abstract. This study calculated the dissolution rates of biogenic silica deposited on the seafloor and the silicic acid benthic flux for 22 Ocean Drilling Program sites. Simple models developed for two host sediment types – detrital and carbonate – were used to explain the variability of biogenic opal dissolution and recycling under present-day low (−0.3 to 2.14 °C) bottom-water temperatures. The kinetic constants describing silicic acid release and silica saturation concentration increased systematically with increasing bottom-water temperatures. When these temperature effects were incorporated into the diagenetic models, the prediction of dissolution rates and diffusive fluxes was more robust. This demonstrates that temperature acts as a primary control that decreases the relative degree of pore-water saturation with opal while increasing the silica concentration. The correlation between the dissolution rate and benthic flux with temperature was pronounced at sites where biogenic opal is accommodated in surficial sediments mostly comprised of biogenic carbonates. This is because the dissolution of carbonates provides the alkalinity necessary for both silica dissolution and clay formation; thus strongly reducing the retarding influence of clays on opal dissolution. Conversely, the silica exchange rates were modified by presence of aluminosilicates, which led to a higher burial efficiency for opal in detrital- than in carbonate-dominated benthic layers. Though model prediction of first-order silica early transformation suggests likely effects from surface temperatures (0–4 °C) on opal-CT precipitation over short geological times (
Bayesian calibration of firn densification models
Authors: Verjans Vincent , Leeson Amber Alexandra , Nemeth Christopher , Stevens C. Max , Kuipers Munneke Peter , Noël Brice , van Wessem Jan Melchior
Published: January 2020

Abstract. Firn densification modelling is key to understanding ice sheet mass balance, ice sheet surface elevation change, and the age difference between ice and the air in enclosed air bubbles. This has resulted in the development of many firn models, all relying to a certain degree on parameter calibration against observed data. We present a novel Bayesian calibration method for these parameters, and apply it to three existing firn models. Using an extensive dataset of firn cores from Greenland and Antarctica, we reach optimal parameter estimates applicable to both ice sheets. We then use these to simulate firn density and evaluate against independent observations. Our simulations show a significant decrease (25 and 55 %) in observation-model discrepancy for two models and a small increase (11 %) for the third. As opposed to current methods, the Bayesian framework allows for robust uncertainty analysis related to parameter values. Based on our results, we review some inherent model assumptions and demonstrate how model- and parameter-related uncertainties potentially affect ice sheet mass balance assessments.
Morphostructural Analysis of Lithuanian National and Regional Parks in the Aspect of the Landscape Geography: 1. Methodology
Authors: Kavaliauskas Paulius
Published: January 2020

The article deals with Lithuanian efforts in the field of protected areas landscape cognition and contributing to the planning system optimization. The summarizing of the state of the problem is presented with special accent to the experience the Estonia, Slovenia and Catalonia as potentially most similar and perspective for Lithuania. The methodology and the algorithm of the morphological study of landscape structure morphological research of Lithuanian National and Regional Parks in 2018-2019 are presented. Distinct landscape units have been designated as landscape environs and landscape sites and have been designated the highest local levels of its cognition. Special attention is paid for territorial differentiation of the landscape morphological structure, main visual aspects of landscape perception, enhancing the awareness of national and regional parks landscape and contributing to the optimization of spatial planning processes.
The Influence of Employee Promotion, Upward Downward Communication and Work Environment on Job Satisfaction of PT. Holcim Indonesia, Tbk
Authors: Yansen Albert , Supriyati Yetti , - Kadir
Published: January 2020

This study aims to determine the influence of employee promotions, upward downward communication, and work environment on employee job satisfaction. This research uses a quantitative approach using a survey method (questionnaire).Path analysis is used to analyse the data collected. The population in this study were all employees of PT. Holcim Indonesia, Tbk, who have a working period of 10 years and over, totalling 510 people spread across all plants in Indonesia. The number of samples taken in this study were 225 people who were randomly selected.The results showed that job satisfaction was directly influenced by employee promotions, upward downward communication, and work environment. The study also found that the work environment was influenced by employee promotion and upward downward communication. This study also found that job satisfaction is indirectly influenced by the promotion and upward downward communication through the work environment. Based on these findings it can be concluded that any changes that occur in employee job satisfaction are influenced by employee promotion, upward downward communication, and work environment. Therefore employee job satisfaction, employee promotions, upward downward communication, and work environment can be taken into consideration in making strategic planning for human resource development.
De betekenis van de 1 juli-uitspraken van de CRvB over exceptieve toetsing van algemeen verbindende voorschriften: exit Landbouwvliegersarrest
Authors: de Vries H.J. (Henk)
Published: January 2020

De betekenis van de 1 juli-uitspraken van de CRvB over exceptieve toetsing van algemeen verbindende voorschriften: exit Landbouwvliegersarrest. En ook: wat is de stand van zaken in het omgevingsrecht?

Dit artikel gaat in op een uitspraak van de CRvB van 1 juli 2019 waarin exceptieve toetsing centraal stond. Auteur vergelijkt de omgevingsrechtelijke jurisprudentie van de ABRvS met betrekking tot exceptieve toetsing met de uitspraak van de CRvB.
De veiligheidsnormering voor primaire waterkeringen onder de Omgevingswet
Authors: Lavrijsen T. (Ton)
Published: January 2020

De veiligheidsnormering voor primaire waterkeringen onder de Omgevingswet

Primaire waterkeringen beschermen ons land tegen overstromingen. De Waterwet bevat normen voor deze waterkeringen. Deze normen krijgen met het Invoeringsbesluit Omgevingswet als omgevingswaarden een plek in het Besluit kwaliteit leefomgeving (Bkl). In dit artikel wordt de voorgenomen inbouw van de waterveiligheidsnormen in het Bkl besproken. De parlementaire behandeling van deze normstelling in het stelsel van de Omgevingswet komt aan bod. Ook komt de kwalificatie van de omgevingswaarden als resultaatsverplichting aan de orde, evenals de uitzonderingen waar een beroep op kan worden gedaan als niet aan de omgevingswaarden wordt voldaan.
Analysis of the texture of rabbit meat subjected
to different means of heat treatment
Authors: Kozioł Konrad , Pałka Sylwia , Migdał Łukasz , Derewicka Olga , Kmiecik Michał , Maj Dorota , Bieniek Józef
Published: January 2020

The aim of this study was to examine the influence of different types of heat treatment on the shear force and texture profile analysis (TPA) of rabbit meat. The research material was meat samples from 22 Blanc de Termonde rabbits. Two samples from the right loin (m. longissimus lumborum) were collected. The first sample was vacuum-packed in a plastic bag and frozen for 72 h at –18 °C; after thawing the samples were immersed in a water bath and boiled for 40 min at 80 °C. The second sample was placed in a plastic frozen-storage bag and frozen for 72 h at –18 °C; after thawing the samples were roasted at 180 °� � � � � � � � � � � � � � C to an internal temperature of 78 °� C. Shear force, hardness, springiness, cohesiveness and chewiness were measured. Significant differences in hardness, cohesiveness and chewiness were found depending on the type of heat treatment. The hardness of the boiled meat was 32% higher than that of the roasted meat, cohesiveness 10% higher, and chewiness 39% higher than in the case of the roasted meat.
Quality in use and nutritional
value of the muscle tissue of zander
(Sander lucioperca) and pike (Esox lucius)
reared in polyculture
Authors: Skałęcki Piotr , Florek Mariusz , Kaliniak Agnieszka , Kędzierska-Matysek Monika , Dmoch Małgorzata
Published: January 2020

The research objective was to compare the quality in use and nutritional value of muscle tissue of zander (Sander lucioperca) and pike (Esox lucius) reared in a polyculture. The research material comprised 16 specimens (8 of each species) captured from one pond in a fish farm situated in the Lublin Voivodeship. The fish were of similar age. The pike, while having a higher body weight, had a higher percentage of guts, and the carcass percentage and a Fulton’s condition coefficient were lower than in the zander. The chemical composition and calorific value of the muscle tissue were very similar for the two species (water 76.40% and 77.15%; protein 21.26% and 21.41%; lipids 0.41% and 0.58%; ash 1.43% and 1.42%; and energy 517 and 528 kJ/100 g for zander and pike, respectively). It is worth noting the high INQ value for the protein of both fish species (6.8 for pike and 6.9 for zander), which indicates that a 100 g portion of zander or pike fillet is a valuable source of protein in the human diet.
Which Emergency Medicine Milestone Sub-competencies are Identified Through Narrative Assessments?
Authors: Diller David , Cooper Shannon , Jain Aarti , Lam Chun , Riddell Jeff
Published: January 2020

Introduction: Evaluators use assessment data to make judgments on resident performance within the Accreditation Council for Graduate Medical Education (ACGME) milestones framework. While workplace-based narrative assessments (WBNA) offer advantages to rating scales, validity evidence for their use in assessing the milestone sub-competencies is lacking. This study aimed to determine the frequency of sub-competencies assessed through WBNAs in an emergency medicine (EM) residency program.

Methods: We performed a retrospective analysis of WBNAs of postgraduate year (PGY) 2-4 residents. A shared mental model was established by reading and discussing the milestones framework, and we created a guide for coding WBNAs to the milestone sub-competencies in an iterative process. Once inter-rater reliability was satisfactory, raters coded each WBNA to the 23 EM milestone sub-competencies.

Results: We analyzed 2517 WBNAs. An average of 2.04 sub-competencies were assessed per WBNA. The sub-competencies most frequently identified were multitasking, medical knowledge, practice-based performance improvement, patient-centered communication, and team management. The sub-competencies least frequently identified were pharmacotherapy, airway management, anesthesia and acute pain management, goal-directed focused ultrasound, wound management, and vascular access. Overall, the frequency with which WBNAs assessed individual sub-competencies was low, with 14 of the 23 sub-competencies being assessed in less than 5% of WBNAs.

Conclusion: WBNAs identify few milestone sub-competencies. Faculty assessed similar sub-competencies related to interpersonal and communication skills, practice-based learning and improvement, and medical knowledge, while neglecting sub-competencies related to patient care and procedural skills. These findings can help shape faculty development programs designed to improve assessments of specific workplace behaviors and provide more robust data for the summative assessment of residents.
Otázky odpovědnosti umělé inteligence za zásah do autorského práva
Authors: Zibner Jan
Published: January 2020

Příspěvek se soustředí na otázky, které vyvstávají v oblasti umělé inteligence při zkoumání odpovědnosti za zásah do autorského práva. S ohledem na nárůst využití umělé inteligence při vytváření autorských děl je v této souvislosti podstatné analyzovat potenciální zásah do autorského práva v procesu tvorby a odpovědnostní režim, který by se v takovém případě uplatnil. V rámci toho je důležité zkoumat jak druh odpovědnosti, odpovědné entity, tak i stávající řešení náhrady škody při dostatečné reflexi vlastností a potenciálu umělé inteligence, jakož i případné návrhy pro futuro v dané oblasti. Příspěvek v první části představí hlavní otázky, které v této problematice vyvstávají. Ve druhé části pak příspěvek představí stávající řešení dříve uvozených otázek, na což naváže třetí část věnovaná návrhům na vhodnější právní úpravu de lege ferenda.
Avaliação em larga escala e educação especial inclusiva: o embate entre duas lógicas
Authors: Witeze Erika Marinho , Silva Régis Henrique dos Reis
Published: January 2020

O artigo discute os embates entre as políticas de educação especial na perspectiva inclusiva e as políticas de avaliação da educação básica. Nós analisamos a escola da rede estadual de Goiás com as maiores médias no Índice de Desenvolvimento da Educação Básica – considerando as primeiras cinco edições do exame nacional. O estudo se concentra nos fatores envolvidos na participação do público-alvo da educação especial na Prova Brasil e problematiza as contradições expressas no confronto entre as políticas inclusivas e a lógica neotecnicista, que orienta as avaliações em larga escala no contexto neoliberal. Os métodos foram: análise documental/bibliográfica; observação participante das rotinas escolares; entrevistas semiestruturadas com gestores, coordenadores pedagógicos, profissionais de apoio à inclusão e professores de recursos. A partir dos dados coletados evidenciamos a coexistência de processos de inclusão/exclusão, resultantes da utilização da Prova Brasil como instrumento de aferição do desempenho de alunos com necessidades educacionais especiais em áreas específicas do currículo. Nossas análises certificaram que a abordagem neotecnicista interfere nas formas de organização do trabalho educativo da escola e na definição dos conteúdos curriculares que serão ministrados pelos professores, em conformidade com as metas definidas pelo Ministério da Educação, pelas agências multilaterais e pelo próprio governo do estado de Goiás. De acordo com os resultados da pesquisa, o ambiente escolar emerge, pois, como espaço de tensão entre diferentes projetos de formação humana, no qual o respeito à diversidade é suplantado pela perspectiva pragmática, mercadológica e classificatória difundida pelos testes padronizados.
La "Crónica de Fernando IV" en el siglo XVI: una compilación inédita de Pedro Barrantes Maldonado
Authors: BENÍTEZ GUERRERO Carmen
Published: January 2020

El manuscrito II/2457 del Palacio Real de Madrid conserva la compilación de una Crónica de Fernando IV que permanece prácticamente desconocida hasta la fecha aunque su encabezamiento dice que fue realizada por Pedro Barrantes Maldonado. Este trabajo pretende llamar la atención sobre la obra, ofrecer una breve presentación tanto del testimonio, como del texto que transmite, y acercarse a las principales diferencias que éste presenta con respecto a su homónima medieval. En este sentido, y para terminar, resultará esencial valorar su relación con los testimonios manuscritos que conocemos de la crónica medieval, lo que permitirá arrojar nuevas pistas acerca de la problemática historia textual de ésta última.

The manuscript II/2457, preserved in the Royal Palace’s library in Madrid provides the compilation of a chronicle of Fernando IV that remains practically unknown so far, although it can be attributed to Pedro Barrantes Maldonado. In this article, I intend to draw attention to this work, presenting a brief description of both the manuscript and the text, and highlighting its main differences with the medieval version. Lastly, I focus on the relationship between Barrantes’ manuscript and the medieval manuscripts of the chronicle in order to come up with new clues about its textual history.
La estructura del primer banco público de Europa: la Taula de Canvi de Barcelona (siglo XV)
Authors: MIQUEL MILIAN Laura
Published: January 2020

El objetivo principal de este estudio es reconstruir el organigrama de la Taula de Canvi de Barcelona desde su nacimiento en 1401 hasta el final del siglo XV. Concretamente, se pasa revista a los oficiales que trabajaron en el banco durante este periodo, intentando establecer claramente cuáles eran sus funciones y cómo evolucionaron a lo largo del Cuatrocientos. Asimismo, se analizan los cambios documentados en su número y en su salario, estrechamente relacionados con las reivindicaciones de tipo laboral que hicieron al municipio. Por último, también se muestran algunos de los principales problemas y disfunciones que afectaron el buen funcionamiento de la Taula durante dicho siglo.

The main objetive of this study is to reconstruct the organisation chart of the Taula de Canvi of Barcelona, from its inception in 1401 to the end of the 15th century. More specifically, we take a look at the officers who worked in the bank during that period of time, in order to clearly establish what their roles were and how that roles evolved over the 1400s. Likewise, the changes documented in their number and salaries are analysed, both aspects closely connected to their labor-related claims to the municipality. Al last, some of the main problems and dysfunctions that affected the correct functioning of the Taula during that century are also shown.
Nacer mudéjar y morir morisco en Valladolid. Contratiempos al cumplimiento del decreto de 1502
Authors: VILLANUEVA ZUBIZARRETA Olatz
Published: January 2020

En 1502 los Reyes Católicos dictaron la pragmática de conversión obligatoria a la fe católica que ponía fin a siglos de presencia de un Islam permitido y vivido en minoría (mudéjar) en la Corona de Castilla. Con él desaparecían un grupo social y religioso plenamente reconocido e integrado en la sociedad castellana, unas instituciones propias igualmente convenidas (aljama) y unos espacios de vecindad propios (morerías) con sus edificios religiosos. En este trabajo nos proponemos contribuir al conocimiento de este hecho histórico y de sus consecuencias a partir del análisis de lo sucedido en la ciudad de Valladolid, por disponer de documentación inédita novedosa que arroja información relevante sobre el tema.

In 1502 the Catholic Monarchs enacted the decree of compulsory conversion to the Catholic faith, a decree that put an end to the secular presence of an Islam that was allowed and lived in minority (as Mudejares) in the Crown of Castile. The decree meant the disappearance of a social and religious group fully recognised and assimilated in Castilian society, which had their own agreed-upon institutions (aljama), neighbourhoods (morería), and religious buildings. The present work purports to further our knowledge of this historical fact and of its consequences, by analysing what happened in the town of Valladolid, since we have new, unpublished documentation that provides significant information on this issue.
Fiktionalitet, faktualitet og fake news
Authors: Nielsen Henrik Skov , Hvidtfeldt Karen
Published: January 2020

I løbet af den amerikanske valgkamp i 2016, som ender med at Donald Trump bliver den 45. præsident i USA, får begrebet fake news ny betydning som en særlig politisk retorik. Med dette temanummer ønsker vi at sætte begrebet i en større sammenhæng såvel historisk som teoretisk, og som titlen på temanummeret antyder, mener vi, at det er frugtbart at tænke på tværs af de tre begreber fiktionalitet, faktualitet og fake news. Fake news er ikke på nogen entydig måde en traditionel fiktionsgenre eller blot at betragte som en faktualitetsgenre. I stedet belyser begreberne hinanden.
Rene toner, falske nyheter
Authors: Brandtzæg Siv Gøril
Published: January 2020

This article discusses skilling ballads as a news medium in the early modern period, and it suggests that in Scandinavia the news ballad was the most important journalistic genre for a broad public. Through a reading of ballads conveying news of fantastical creatures, the article considers how skilling ballads negotiated the borders between the true and the false, and how some of our contemporary mechanisms for revealing fake news can be detected in the early modern news ballads.
Arquitectura de la información de la v3 de Mosaic
Authors: Giménez Ferran , Ripoll Anna
Published: January 2020

Los responsables de Mosaic decidieron afrontar la reconceptualización de esta publicación digital para mejorarla y adaptarla a las necesidades y tendencias actuales de las publicaciones digitales. El caso descrito a continuación sólo abarca la fase de definición de su arquitectura de la información.
WEBP, nuevo formato de imagen para la web
Authors: Melenchón Maldonado Javier
Published: January 2020

Google ha propuesto un nuevo formato para codificar imágenes llamado WEBP orientado para aplicarse a imágenes que se cuelguen en páginas web. WEBP de Google es un formato comprimido que se basa en el proceso que se utiliza en el VP8 para codificar una imagen independientemente del resto de imágenes.
Análisis en video de un spot publicitario
Authors: Casado Eva
Published: January 2020

Eva Casado ha realizado un trabajo sobre análisis en vídeo de un spot publicitario para la asignatura de Composición Digital. El spot elegido ha sido “Normal”, en el que Voll Damm anuncia de un modo bastante característico una de sus cervezas. En este escrito nos cuenta su proceso de trabajo.
Relationship between Nurses’ Knowledge of Initial Assessment and Application of Early Warning System At Emergency Department of Type A Hospital In Jakarta
Authors: Purnamasari Sekar Dwi , Aryani Denissa Faradita
Published: January 2020

Objective: Early warning system (EWS) is a physiological scoring to observe the patient’s condition not only in hospital wards but also in Emergency Department (ED). At an overcrowded ER that have slow of patient flow, EWS is use as an early detection of patient’s deterioration by observing the vital signs. The purpose of this study was to identify the relationship between nurses’ knowledge of initial assessment and the application of EWS at emergency department.

Methods: This was a quantitative study that used descriptive correlative with cross-sectional design toward 70 emergency nurses.

Results: The result showed there was a relationship between nurses’ knowledge of initial assessment and the application of early warning system at emergency room (p=0 .001)

Conclusion: The higher the level of nurses’ knowledge, their behavior is better. It is recommended to maintain the use of EWS in ED that already good through training regularly (re-certification).

 

Keywords: Early warning system; emergency department; initial assessment; nurses’ knowledge.
Descriptive Study: Self Motivation of Patients Undergoing Routine Hemodialysis with Fluid Restriction
Authors: Wisudawati Megasari Yanuar , Arista Liya
Published: January 2020

Objective: End Stage Renal Disease (ESRD) is one of diseases that take as second causes of death in Indonesia. Patients with ESRD have to undergo routine hemodialysis for temporary renal replacement therapy. Patients who are undergoing hemodialysis should do fluid restrictions in order to avoid excess fluid. To maintain the fluid balance, patients need self motivation to make fluid restriction. The aim of this research was to determine of self motivation for patients undergoing hemodialysis with fluid restriction while using Treatment Motivation Questionnaire.

Methods: This research was a descriptive study with cross sectional approach performed 94 patients undergoing hemodialysis consecutively at unit hemodialysis.

Results: The result showed 63.8% of patients undergoing hemodialysis have a low motivation of fluid intake restriction.

Conclusion: Suggestion for hospital is to organize focus group discussion about basic knowledge of fluid restriction, how to maintain fluid restriction with IDWG graphs and to share patient’s self motivation of fluid restriction.

 
Keywords: ESRD, fluid restriction, hemodialysis, motivation
The Relationship Between Family Support and the Quality of Post Primary PCI Patients’ Life
Authors: Munawaroh Lailiyatul , Herawati Tuti
Published: January 2020

Objective: ST elevation myocardial infarction is the most common myocardial infarction cases. The main intervention of this case is primary percutaneous coronary intervention (PPCI). After PPCI, quality of life in STEMI patients depend on their ability to control the risk factors of reinfarction. In this condition, patients need family support. Therefore, this study aimed to identify the relationship between family support and quality of patients’ life after PPCI.

Methods: This was a descriptive study with cross sectional design. We recruited a purposive sample of 34 STEMI post- Primary PCI patients. We employed the modified family support questionnaire (Hensarling Diabetes Family Support Scale) and the quality of life questionnaire to collect data. Data, then, were analyzed using univariate and bivariate analyses.

Results: The mean score of the family support was 64.44, with the minimum score of 21 and maximum score of 75.  More patients received good family support than those who received poor family support. On the other hand, the mean score of patients’ life quality was 68.36, ranging from 25.1-98.43. There was a weak and positive correlation between family support and quality of patients’ life. However, the relationship was insignificant.

Conclusion: Family support was not significantly related to quality of STEMI patients’ life. Further studies to identify factors contributing to the quality of STEI patients’ life are needed. 

Key words: family support, percutaneous coronary intervention, quality of life, ST elevation myocardial infarction  
The inflated mitochondrial genomes of siphonous green algae reflect processes driving expansion of noncoding DNA and proliferation of introns
Authors: Repetti Sonja I. , Jackson Christopher J. , Judd Louise M. , Wick Ryan R. , Holt Kathryn E. , Verbruggen Heroen
Published: January 2020

Within the siphonous green algal order Bryopsidales, the size and gene arrangement of chloroplast genomes has been examined extensively, while mitochondrial genomes have been mostly overlooked. The recently published mitochondrial genome ofCaulerpa lentilliferais large with expanded noncoding DNA, but it remains unclear if this is characteristic of the entire order. Our study aims to evaluate the evolutionary forces shaping organelle genome dynamics in the Bryopsidales based on theC. lentilliferaandOstreobium quekettiimitochondrial genomes. In this study, the mitochondrial genome ofO. quekettiiwas characterised using a combination of long and short read sequencing, and bioinformatic tools for annotation and sequence analyses. We compared the mitochondrial and chloroplast genomes ofO. quekettiiandC. lentilliferato examine hypotheses related to genome evolution. TheO. quekettiimitochondrial genome is the largest green algal mitochondrial genome sequenced (241,739 bp), considerably larger than its chloroplast genome. As with the mtDNA ofC. lentillifera, most of this excess size is from the expansion of intergenic DNA and proliferation of introns. Inflated mitochondrial genomes in the Bryopsidales suggest effective population size, recombination and/or mutation rate, influenced by nuclear-encoded proteins, differ between the genomes of mitochondria and chloroplasts, reducing the strength of selection to influence evolution of their mitochondrial genomes.
Identification of biological pathways and genes associated with neurogenic heterotopic ossification by text mining
Authors: Zhang Yichong , Zhan Yuanbo , Kou Yuhui , Yin Xiaofeng , Wang Yanhua , Zhang Dianying
Published: January 2020

Background

Neurogenic heterotopic ossification is a disorder of aberrant bone formation affecting one in five patients sustaining a spinal cord injury or traumatic brain injury (SCI-TBI-HO). However, the underlying mechanisms of SCI-TBI-HO have proven difficult to elucidate. The aim of the present study is to identify the most promising candidate genes and biological pathways for SCI-TBI-HO.

Methods

In this study, we used text mining to generate potential explanations for SCI-TBI-HO. Moreover, we employed several additional datasets, including gene expression profile data, drug data and tissue-specific gene expression data, to explore promising genes that associated with SCI-TBI-HO.

Results

We identified four SCI-TBI-HO-associated genes, including GDF15, LDLR, CCL2, and CLU. Finally, using enrichment analysis, we identified several pathways, including integrin signaling, insulin pathway, internalization of ErbB1, urokinase-type plasminogen activator and uPAR-mediated signaling, PDGFR-beta signaling pathway, EGF receptor (ErbB1) signaling pathway, and class I PI3K signaling events, which may be associated with SCI-TBI-HO.

Conclusions

These results enhance our understanding of the molecular mechanisms of SCI-TBI-HO and offer new leads for researchers and innovative therapeutic strategies.
The crystal structure of the TCP domain of PCF6 in Oryza sativa L. reveals an RHH‐like fold
Authors: Sun Lifang , Zou Xiaoming , Jiang Meiqin , Wu Xiuling , Chen Yayu , Wang Qianchao , Wang Qin , Chen Lifei , Wu Yunkun
Published: January 2020

The Teosinte branched 1/Cycloidea/Proliferating cell factor (TCP) domain is an evolutionarily conserved DNA binding domain unique to the plant kingdom. To date, the functions of TCPs have been well studied, but the three‐dimensional structure of the TCP domain is lacking. Here, we have determined the crystal structure of the TCP domain from OsPCF6. The structure reveals that the TCP domain adopts three short β‐strands followed by a helix–loop–helix structure, distinct from the canonical basic helix–loop–helix structure. This folded domain shows high structural similarity to the ribbon–helix–helix (RHH) transcriptional repressors, a family of DNA binding proteins with a conserved 3D structural motif (RHH fold), indicating that TCPs could be reclassified as RHH proteins. Our work will provide insight toward a better understanding of the mechanisms underlying TCP protein function.
Progress in development of electrocatalyst for CO2 conversion to selective CO production
Authors: Nguyen Dang Le Tri , Kim Younghye , Hwang Yun Jeong , Won Da Hye
Published: December 2019

The conversion of carbon dioxide (CO2) to valuable fuels and chemicals offers a new pathway for sustainable and clean carbon fixation. Recently, the focus has been on electrochemical CO2 reduction on heterogeneous electrode catalysts, leading to remarkable achievements in the reaction performance. To date, CO2 to carbon monoxide (CO) conversion is considered as the most promising candidate reaction for the industrial market, owing to its high efficiency and reasonable technoeconomic feasibility. Moreover, CO has been proposed as a key intermediate species for further reduced hydrocarbons, which can pave the way for various fuel production. This study sets out to describe recent progress on the electrochemical CO2 reduction to CO in a heterogeneously catalyzed system. The review includes understanding of the catalytic material employed and engineering strategies implemented by adjusting the binding energy of key adsorbates. These material design approaches, such as nanostructuring, alloying, doping, and so forth, have pioneered breakouts in the intrinsic catalytic nature of transition metal elements. Moreover, recent advances in systematic design are summarized, with focus on practical industrial applications. Finally, perspectives on the design of electrocatalyst materials for CO production by electrochemical CO2 reduction are presented.
Optimizing Electron Densities of Ni‐N‐C Complexes by Hybrid Coordination for Efficient Electrocatalytic CO2 Reduction
Authors: Wang Zhong‐Li , Choi Jaecheol , Xu Mingquan , Hao Xianfeng , Zhang Hao , Jiang Zheng , Zuo Ming , Kim Jeonghun , Zhou Wu , Meng Xianguang , Yu Qing , Sun Zhihu , Wei Shiqiang , Ye Jinhua , Wallace Gordon G. , Officer David L. , Yamauchi Yusuke
Published: December 2019

Metal‐N‐C is a type of attractive electrocatalyst for efficient CO2 reduction to CO. Because of the ambiguity in their atomic structures, the active sites and catalytic mechanisms of the catalysts have remained under debate. Here, the effects of N and C hybrid coordination on the activity of Ni‐N‐C catalysts were investigated, combining theoretical and experimental methods. The theoretical calculations revealed that N and C hybrid coordination greatly enhanced the capability of single‐atom Ni active sites to provide electrons to reactant molecules and strengthens the bonding of Ni to N and C in the Ni‐N‐C complexes. During the reaction process, the C and N coordination synergistically optimized the reaction energies in the conversion of CO2 to CO. A good agreement between theoretical calculations and electrochemical experiments was achieved based on the newly developed Ni‐N‐C electrocatalysts. The activity of hybrid‐coordination NiN2C2 was more than double that of single‐coordination NiN4.
Improving integrity of RC beam‐column joints with deficient beam rebar anchorage
Authors: Wardi Syafri , Sanada Yasushi , Saha Nandita , Takahashi Susumu
Published: January 2020

In recent earthquakes in developing countries, severe damage was observed on reinforced concrete buildings. This study focuses on exterior beam‐column joints with substandard beam rebar anchorage and seismic strengthening by installing wing walls. First, a series of experiments was conducted to investigate the seismic behavior of exterior joints with substandard beam rebar anchorage representing typical Bangladeshi buildings. Two 0.7‐scaled exterior joint specimens were tested, and these specimens showed beam rebar anchorage failure and/or joint shear failure. Prior to strengthening of the joint, a series of pullout tests was conducted on postinstalled bonded anchors in low‐strength concrete for strengthening design. Then, an experiment was performed to apply the strengthening method by wing walls to one of the exterior joint specimens to improve the integrity, and this method was intended to prevent the failure of beam rebar anchorage. The strengthening method is proposed to extend the development length of beam longitudinal bars by considering the embedment length along the wing walls. The test results verified the effectiveness and applicability of the proposed strengthening method to upgrade exterior RC beam‐column joints with deficient beam rebar anchorage.
Flavored functional drinking yogurt (Doogh) formulated with Lactobacillus plantarum LS5, cress seed gum, and coriander leaves extract
Authors: Shariati Zahra , Jouki Mohammad , Rafiei Flora
Published: December 2019

The effects of coriander extract (CE) and cress seed gum (CSG) on viability of Lactobacillus plantarum LS5 and physicochemical properties of drinking yogurt (Doogh) were evaluated. The CE contained 18 mg GAE/g and was shown by the DPPH radical assay to have remarkable antioxidant activity. The CE was added at concentrations of 0%, 0.05%, 0.1%, and 0.25%, and the levels of added CSG were 0%, 0.1%, 0.25%, and 0.5%. Doogh samples were analyzed after 1, 2, and 3 weeks of storage at 4°C. By increasing the amounts of CSG, the viscosity of the Doogh samples was increased and phase separation was reduced significantly (p < .05). The results also showed that by increasing the levels of CSG to 0.5%, L. plantarum count increased significantly (p < .05). Doogh sample containing 0.05% CE and 0.5% CSG gained the highest probiotic count, overall acceptability score, and lowest lipid oxidation and phase separation in comparison with the other samples.
Reclaiming the social in socialization: A practice‐based understanding of newcomer adjustment
Authors: Harris Lisa , Cooper‐Thomas Helena , Smith Peter , Smollan Roy
Published: January 2020

The socialization of an employee into a new role provides an opportunity for both the newcomer and the organization to maintain or improve current practices. In this paper, integrating ideas from a practice‐based perspective with the concept of sensemaking, we draw on the multiple perspectives provided by the newcomer and relevant colleagues to examine the socialization process. Using an inductive, qualitative approach analyzing 21 semi‐structured interviews in six organizations with four types of participant—newcomers, and their respective coworkers, managers, and human resource (HR) representatives—our findings shed light on how interactions between newcomers and these three types of insiders influence newcomers' enactment of organizational practices. Specifically, newcomers who received greater sensegiving from insiders had, in turn, more opportunity to sensetest their nascent understandings, and to sensemake using these inputs, leading to the replication of organizational practices. Conversely, newcomers with limited access to sensegiving were less able to sensetest, and instead relied more on previous experiences to make sense of their new environment, leading to the determination of practices. Newcomers with substantial prior work experience used this as a valuable input to sensemaking, allowing quasi‐replication and determination of organizational practices that were more likely to be accepted, although not always. Our findings highlight social aspects of socialization as integral to sensemaking processes and performance of practice. In order to optimize socialization, all stakeholders—newcomers, their colleagues, and HR—should consider how the fundamentally social nature of socialization might require each party to adapt their approach.
Reframing Literacy Assessment: Using Scales and Micro‐Progressions to Provide Equitable Assessments for All Learners
Authors: Childress Jennifer , Backman Alysia Cella , Lipson Marjorie Y.
Published: December 2019

In this commentary, the authors suggest that a paramount job for adolescent literacy assessment is to create more equitable outcomes for all students. The authors propose that the use of learning scales and micro‐progressions fills a void and demonstrate how their use can provide better information to teachers and yield information that can improve students’ self‐efficacy.
University Faculty Talk About Practitioner Research: A Conversation
Authors: Marsh Josephine Peyton , Gonzalez Deborah
Published: December 2019

This forum highlights research that literacy teachers, students, and others can explore, use, or adapt as they provide literacy instruction and develop related programs and research agendas.
The Multidimensional Model of Broaching Behavior
Authors: Day‐Vines Norma L. , Cluxton‐Keller Fallon , Agorsor Courtney , Gubara Sarah , Otabil Nana Aba A.
Published: January 2020

The multidimensional model of broaching behavior (MMBB) is introduced as a heuristic that addresses multicultural counseling and social justice competence. The MMBB includes humanistic skills that allow counselors to broach clients’ racial, ethnic, and cultural (REC) concerns in an effort to develop strong therapeutic alliances and alleviate distress. This article provides illustrative examples of the 4 MMBB dimensions: intracounseling, intraindividual, intra‐REC, and inter‐REC. Implications for the counseling profession and practice are described, and directions for future research are presented.
Seasonal variations of digestive enzymes in sea cucumbers (Holothuria tubulosa, G. 1788) under culture conditions
Authors: Günay Deniz , Emiroğlu Dilek , Suzer Cüneyt
Published: December 2019

Sea cucumber, Holothuria tubulosa (Gmelin, 1788), is an economically valuable species due to its rich nutrients content that being exported in Turkey. However, culture of this species is difficult due to a lack of knowledge. The main objective of this study is to investigate seasonal activities of main digestive enzymes (protease, lipase, and amylase) for nutritional requirements. In this sense, sea cucumbers were stocked in the glass aquarium and sediment was 10 cm. It was replaced monthly and enriched (1% of the living individual weight) by dried Sargassum sp. Total protease and amylase enzymes have shown higher activity compared to lipase. All three enzyme activities were maximum in the summer and minimum in the winter. In summer, the highest measured total protease, amylase, and lipase activity values were 6.45 ± 0.66, 6.77 ± 0.72, and 2.78 ± 0.32 U/mg per protein, respectively. In winter, the lowest total protease, amylase, and lipase activity values were measured as 2.03 ± 0.16, 1.14 ± 0.14, and 0.12 ± 0.01 U/mg per protein, respectively. As a conclusion of the study, seasonal expression of the main digestive enzymes was strictly dependent on water temperatures and food abundance and also it was ideal to feed this species with food containing high protein and carbohydrate under appropriate temperatures for commercial culture.
Characterization of Complex Branched Polymers by Multidetector Thermal Field‐Flow Fractionation
Authors: Murima Douglas , Pasch Harald
Published: December 2019

Size exclusion chromatography (SEC) for the molar mass analysis of polymers is of limited use for the analysis of branched polymers due to the co‐elution of linear and branched molecules with similar hydrodynamic sizes but different molar masses. Thermal field‐flow fractionation (ThFFF) in combination with multiple detection methods is a versatile alternative to SEC due to the fact that fractionation is not based entirely on molecular size but the interplay of thermal and translational diffusion that depend on molecular topology and molecular size. Multidetector ThFFF is used to investigate the correlation of branching and molar mass by determining polymer conformations from Mark–Houwink plots and the degrees of branching using functionality plots. The suitability of this approach is demonstrated for a set of 3‐, 4‐, and 6‐arm star polystyrenes as well as a more complex hyperbranched polybutadiene‐polystyrene copolymer. It is shown that ThFFF is a powerful tool for the analysis of the radius of gyration and the hydrodynamic radius when coupled online to static light scattering, viscometry, and dynamic light scattering. Shape factors are evaluated as influenced by branching where narrow dispersed star polystyrenes are used as model systems for the analysis of the more complex hyperbranched polybutadiene–polystyrene copolymer.
Bifurcation for a free boundary problem modeling the growth of multilayer tumors with ECM and MDE interactions
Authors: Lu Junfan , Hu Bei
Published: January 2020

We study a free boundary problem modeling the growth of multilayer tumors. This model describes the invasion of tumors: the tumor cells produce matrix degrading enzymes (MDEs) to degrade the extracellular matrix (ECM) which provides structural support of the surrounding tissue. As in Pan and Xing, the influence of ECM and MDE interactions is considered in this paper. The model equations include two diffusion equations for the nutrient concentration and MDE concentration and an ordinary differential equation for ECM concentration. The tumor cell proliferation is at the rate
, which characterizes the aggressiveness of the tumor. In contrast to Pan and Xing, we consider “flat stationary solution” in this paper. We first show that there exists a unique flat stationary solution for any
. Then, we prove that there are infinite branches of bifurcation solutions from the flat stationary solutions at the bifurcation points
(
).
Flexible EBG‐backed PIFA based on conductive textile and PDMS for wearable applications
Authors: Gao Guoping , Wang Shaofei , Zhang Ruifeng , Yang Chen , Hu Bin
Published: December 2019

A wearable planar inverted‐F antenna (PIFA) fed by the coplanar waveguide (CPW) and backed with an optimized electromagnetic bandgap (EBG) structure is presented. The antenna is made of conductive textile and polydimethylsiloxane (PDMS), which is a conformal and robust solution to wearable applications. The EBG unit cell is miniaturized according to the equivalent circuit model, and the cross‐polarization is suppressed due to its approximate 180° reflection phase in the orthogonal direction. The measured impedance bandwidth ranges from 2.30 to 2.65 GHz, which covers the 2.4 GHz Industrial Scientific Medical (ISM) band. The antenna keeps a high gain and efficiency above 70% under different conditions including being flat, bent, and close to the human body. The maximum SAR value is limited to 0.612 and 0.330 W/kg under 1 and 10 g standard, respectively. Therefore, the antenna is a promising candidate for wearable applications in various domains.