bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating the M6 learning model and realistic mathematics education (RME) approach in enhancing critical thinking skills in mathematics: A focus on students’ logical-mathematical intelligence
Authors: Susandi Ardi Dwi , Sudirman Sudirman , Khoiriyah Binti
Published: January 2025

Background: Critical thinking skills are essential in the 21st century; however, Indonesian students often show low critical thinking abilities in mathematics. This issue arises partly from limited use of instructional methods that foster critical thinking among junior high school students.Aim: This study aims to assess the effectiveness of the M6 learning model and Realistic Mathematics Education (RME) in enhancing students' critical thinking abilities in mathematics, considering their levels of logical-mathematical intelligence.Method: A quasi-experimental design was employed with a sample of 318 seventh-grade students from State Middle Schools in Cirebon Regency in the 2023/2024 academic year. Stratified cluster random sampling produced three groups: 107 students in the first experimental group, 105 in the second, and 106 in the control group. Instruments included a critical mathematical thinking skills test and a logical-mathematical intelligence test, with hypothesis testing conducted using two-way analysis of variance with unequal cells.Results: The analysis revealed significant differences in students' critical thinking abilities based on the learning model and logical-mathematical intelligence levels, with notable interactions between these variables.Conclusion: The study concludes that the M6 and RME learning models influence critical mathematical thinking skills differently across logical-mathematical intelligence categories. These findings underscore the importance of aligning instructional models with students' intelligence profiles to optimize learning outcomes in critical thinking.
Using the realistic mathematics education (RME) approach with scaffolding to enhance mathematical representation ability
Authors: Putra Rizki Wahyu Yunian , Sutiarso Sugeng , Nurhanurawati Nurhanurawati
Published: January 2025

Background: Mathematical representation skills are essential for understanding and applying mathematical concepts. However, many students struggle to connect abstract concepts to real-life situations, making it difficult for them to improve their representation skills.Aim: This study aims to develop and test the effectiveness of the Realistic Mathematics Education (RME) approach, supported by scaffolding, in improving students' mathematical representation skills.Method: The study followed the ADDIE model, which includes five steps: Analysis, Design, Development, Implementation, and Evaluation. The participants were 50 second-semester students from classes A, C, and D in the Mathematics Education program at UIN Raden Intan Lampung.Results: The development of the Realistic Mathematics Education (RME) model with scaffolding was validated by eight expert validators, confirming its validity and practicality. The model was designed to align with learning objectives, incorporate real-world contexts, and provide structured scaffolding tailored to students’ needs. During implementation, the model demonstrated practicality as students actively engaged with learning activities and gradually developed independence in problem-solving. The effect size calculation of 0.9, categorized as high, confirmed the model’s effectiveness in significantly enhancing students' mathematical representation skills.Conclusion: The RME approach with scaffolding is an effective method to improve the quality of mathematics learning in higher education. It helps students better understand and apply mathematical concepts by linking them to practical problems.
Accurate Monitoring of Lithium-Ion Battery Performance through Adaptive Unscented Kalman Filters
Authors: Yogesh Anil Jadhav , Bhargava Ashish
Published: January 2025

The sources of modern energy with the best combinations of energy density, cycles, and weight include lithium-ion batteries. It covers a vast area from electric vehicles to the storage of renewable energy. Though there are some significant advantages to LiBs, estimations of the specific values of their performance parameters, State of Charge (SOC), and State of Health (SOH), are inadapted or irrelevant. They emerge from their nonlinear behavior, dynamic operating conditions, and aging effects. This paper surveys advanced estimation techniques, focusing on the Adaptive Unscented Kalman Filter, a method superior to traditional ones, such as the Extended Kalman Filter (EKF) and Unscented Kalman Filter (UKF). Its adaptability allows AUKF to improve accuracy and robustness in SOC and SOH monitoring to address the added complexities in the management of a battery. In addition, hybrid approaches combining physics-based and AI-driven models are discussed to give better estimation and to reduce modelling errors. Practical demonstrations of these approaches have been very effective in improving battery performance and safety. It also discusses the emerging trend of second-life batteries and innovative dispatch strategies that consider degradation models and real-time SOH estimation. This therefore calls for the adoption of more advanced hybrid frameworks to enhance battery efficiency, reliability, and sustainability, thus pushing the frontiers of energy storage technologies.
Digital transformation through electronic-based government system performance as public relations strategy
Authors: Fardiah Dedeh , Darmawan Ferry , Rinawati Rini , Supaat Viky Edya Martina , Hadnansyah Edwan
Published: January 2025

Background: West Java Province is advancing towards digital governance with the West Java Digital Service. In 2023, it received the Indonesian Regional Government Appreciation Award for Integrated Digital Transformation from B-Universe. The revamped jabarprov.go.id portal provides an integrated one-stop public service platform, enhancing public access to information and services. Integration across regional, district, and city agencies has simplified portal management. The government’s approach to digital transformation includes adopting an electronic-based government system (SPBE) as part of its public communication strategy. This study explores the effectiveness of digital transformation via SPBE for communication advancement by the West Java Regional Government. It assesses its impact on public accessibility and service efficiency. Methods: This study uses a case study method and Focus Group Discussions with E-government managers in 28 cities/regencies in West Java. Results: The study reveals that public communication encompasses services for society, businesses, government, and ASN. Interaction processes involve infrastructure development, information provision, two-way interaction, and managing feedback. Information transactions include a complaint platform, guidelines, complaint submission, verification, handling, confirmation, resolution, and evaluation. Collaborations span government, society, the private sector, NGOs, academia, and international partners. Public communication optimation improves satisfaction, efficiency, transparency, accountability, and participation. Conclusion: Digital transformation through SPBE enhances efficiency, transparency, and public involvement, with government public relations crucial for supporting and optimizing SPBE performance. Implication: The research implies that the government should enhance information models for broader accessibility, which covers those with physical or digital limitations, and facilitate two-way interactions through digital platforms, AI, and Chatbots. Besides, education and socialization regarding SPBE services are fundamental.
Therapeutic options in the treatment of inflammatory glaucoma
Authors: Kaczmarek Julia , Wolińska Natalia , Pigoński Alan , Papież Monika , Pyza Aneta , Alsoubie Ismael , Papachristoforou Natalie , Piórek Jakub , Ueno Anthony , Sajak-Hydzik Katarzyna , Pawlicka Ilona , Piskorz Agnieszka , Kozak Maciej , Roszkowska Anna Maria
Published: January 2025

Therapeutic options in inflammatory glaucoma, both pharmacological and surgical methods, have been presented in this paper. Main goals of pharmacotherapy are: controlling inflammation and reducing intraocular pressure. Anti-inflammatory drugs primarily include topical glucocorticosteroids but also nonsteroidal anti-inflammatorydrugs and immunomodulatory therapy. Elevated intraocular pressure is treated with β-blockers, carbonic anhydrase inhibirozpotors, prostaglandin analogues and α2-adrenergic receptor agonists. If pharmacological treatment does not produce the desired results, surgical treatment must be considered. Due to the risk of reactivation of inflammation, it is recommended that it be performed 3 months after the inflammation has healed. Currently, trabeculectomy remains the gold standard. Among the invasive treatment techniques, we discuss trabeculectomy with the use of mitomycin C, micro-hook trabeculectomy, laser therapy, glaucoma drainage implants, deep sclerectomy and viscocanalostomy.
Is there a relationship between the microbiome of the paranasal sinuses and nasal cavity and the primary acquired nasolacrimal duct obstruction? Literature review
Authors: Karłowska-Bijak Olga , Kokoszka Magdalena , Misiołek Maciej , Makuch-Stryjewska Grażyna , Pawlicki Dominik
Published: January 2025

Hormonal factors, atopy, viral infections, gastroesophageal reflux, ischemic heart disease and swimming in a pool are believed to affect the development of primary acquired nasolacrimal duct obstruction (PANDO). It is suggested that patients with PANDO have more advanced inflammatory lesions revealed by the tomographic examination of the paranasal sinuses. The authors’ aim was to answer the question whether there is a connection between the chronic inflammation and disruption of the microbiome of the nasal cavity and sinuses and the development of inflammation in the lacrimal ducts.
Pubmed.gov was the information source. Years reviewed included 2018 to 2023. Inclusion criteria included presence of an abstract, pathology of the nasolacrimal ducts, acute and chronic inflammation of the nasolacrimal ducts, papers written in English, studies on humans, publications regarding pathology of the lacrimal sac and paranasal sinuses, case report. The exclusion criteria included: lack of abstract, pathologies of other sections of the drainage system, pathology of the nasolacrimal ducts, other than chronic or acute inflammation, papers written in a language other than English, lack of case report. No gender criterion was used.
Based on the data available in the literature, only 7 studies described the co-occurrence of pathologies of the lacrimal ducts and paranasal sinuses. Only 4 publications contained information on the microbiome and identified Streptococcus intermedius and Staphylococcus aureus, and in 2 cases no increase in pathological flora was revealed.
The question about the relationship between the microbiome of the lacrimal sac and the paranasal sinuses and their mutual impact on the developing inflammation has not been answered, which, according to the authors, requires further research.
Homocystinuria as a cause of ocular complications requiring surgical intervention
Authors: Cywiński Adam , Rzeźwicki Szymon , Bednarski Łukasz
Published: January 2025

A 41-year-old man underwent surgery in both eyes due to diagnosed lens subluxation with significant decrease in visual acuity. In the left eye, an acute attack of angle-closure glaucoma caused by lens subluxation into the anterior chamber resulted in a combined procedure of lensectomy with posterior vitrectomy and silicone oil endotamponade due to iatrogenic retinal detachment. In the right eye, a procedure was performed to remove the subluxated natural lens with simultaneous intrascleral fixation of an artificial lens. During this procedure, the author’s “Vampire” technique was used to facilitate the removal of the practically subluxated natural lens and reduce the risk of vitreous loss. Due to intraoperative complications, the left eye required further surgical procedures. Silicone oil removal from this eye was combined with repeat diagnostic testing to identify the cause of lens subluxation. The cause was found to be previously undiagnosed homocystinuria.
Traditional foodways of the Amadiba: A struggle for indigenous food sovereignty in Mpondoland, South Africa
Authors: Kesselman Brittany , Zukulu Sinegugu
Published: January 2025

We argue that an "actually existing alternative" to the industrial food system can be found in the Amadiba community in South Africa. Like other indigenous food systems, Amadiba traditional foodways are underpinned by principles such as interconnection, sacredness, gratitude, abundance and collectivism, rather than growth or profit. The Amadiba community has struggled to protect the land and sea upon which their foodways depend, in the face of attempts by the South African government and international corporations to impose 'development' projects. This indigenous food sovereignty struggle highlights the principles-based Amadiba food system as a model for prioritizing social and ecological needs.
Education on clean and healthy living behavior and wise use of medicine at the Al-Qur'an Tahfidz Boarding School Jami' Baitusshalihin [Edukasi perilaku hidup bersih dan sehat serta bijak menggunakan obat di Pesantren Tahfidz Al-Qur'an Jami' Baitusshalihin]
Authors: Bakri Tedy Kurniawan , Suryawati S , Suardi Hijra Novia , Fahlevi Heru , Adella Shylvana , Dharma Rudi , Meriyana Cut Melda , Raihanah R
Published: January 2025

A healthy and clean environment can be created starting from self-awareness and the surrounding community. A clean environment fosters a healthy life and is free from various diseases. Clean and Healthy Living Behavior (PHBS) is an action to prevent the occurrence of diseases and improve health levels. Disease disorders caused by poor sanitation in the boarding school environment certainly require further treatment, one of which is by consuming certain drugs. The steps in obtaining, using, storing, and disposing of drugs need to be known by students in order to maximize the healing of their illnesses. The purpose of this service is to increase awareness among students about the importance of maintaining personal and environmental hygiene, as well as to provide the right knowledge about the use of drugs. The methods used in this community service include lectures, discussions, educational videos, and simulations. The results of this community service indicate an increase in the understanding and knowledge of students regarding clean living patterns. Boarding school managers also gained a better understanding of the importance of proper sanitation in the boarding school environment and how to use drugs properly and correctly. In conclusion, there is an increase in students' understanding of clean-living patterns and knowledge of how to use drugs appropriately.
Construcción y transmisión de imágenes a través de la historiografía literaria francófona
Authors: FIGUEIRAS CATOIRA Carla
Published: January 2025

Paul Ricoeur reminds us that literature, after having restored to the collective memory a part of the forgetting — voluntary or not — must be interpreted and read. This is why the revision of historiographic texts requires an awareness of the selections, and therefore the delimitations that are made in the elaboration of historical discourse. What are the elements chosen to delimit and present African literatures? What narrative has been developed in order to construct a collective identity around the repertoire reinterpreted in literary histories? What critical and historical discourses are privileged in the teaching of African literatures in France? This article aims to analyse the historiographies of African literature in French published in the 1990s in order to present the imaginary communities constructed: how was Africa thought of?
L’imaginaire du « corps-institution » dans la prose romanesque de Michel Houellebecq
Authors: ATANGANA NGONO Denis Adrien
Published: January 2025

The purpose of this study is to show, based on the romantic writing of Michel Houellebecq, that the human body has acquired new properties which make it an enterprise in its own and therefore an institution. What G.Wallet (2003) designates by ‘body-institution’ because, through the enterprise of his body, the individual governs himself to exist in the economic world and influences the economic system through activities that are more or less profitable. This study would like to question the mentalities of recognition and potential in the economic system. Based on the thematic criticism of Jean Pierre Richard (1961) which deals with the theme and its reasons, associated with the sociopoetics of G. Molinié and A. Viala (1993) which establishes the relationship between esthetics and ideology, we will show the configuration of the body of writing, will analyse its textual representatives and will arrive at the conclusion that the imagination of the ‘body-institution’ is the expression of a new state of capitalism of vulnerabilities.
Traduction du discours humaniste dans Les Déboires de Dieudonnée de Francis Beng Nyamnjoh
Authors: ETOGA Grace Bemessenlitie , ATOUGA Jean Pierre
Published: January 2025

This study stemmed from the observation that English-speaking Cameroonian literature makes use of humanist discourse among many others to denounce the failings of leaders and the misery of peoples in a bilingual and multicultural context. Translating, therefore, texts imbued with humanist discourse could be a challenge for the literary translator, despite being an intercultural mediator. With regard to this skill, does the translator’s strategy succeeded in preserving the essence and richness of the original text destined from the start for a French readership? In this light, the analysis below examined the translation and meaning preservation of the structuring elements of the said discourse in Francis Nyamnjoh's Les Déboires de Dieudonné. Thus, based on Berman’s Translation Critism which convened Touré's Descriptive Translation Studies (DTS) and focusing on few extracts taken from the aforementioned corpus, our analyses aim first to identify the structuring elements of Nyamnjoh's humanist discourse, then to describe the strategy and procedures employed by the translator, and finally to justify in the post-colonial literature framework, the scope of the author's discourse in French. The results obtained after this study shows that the translator used 86% of foreignization, against 14% of naturalization. These results lead us to conclude that literal translation is par excellence, the indispensable procedure in the translation of literary works, in other words it remains the guarantor of a scrupulous morphosyntactic analysis and a correct semantic analysis of the lexemes in the text.
System that Facilitates Communication for People With Speech Difficulties With Artificial Intelligence Techniques
Authors: Cruz-Guerrero René , Simón-Marmolejo Isaías , Hernández Elias Ruíz , Fragoso Karina Gutierrez
Published: January 2025

Objective: To develop a communication system for people with speech difficulties that allows them to express their needs by issuing instructions to the computer with minimal eye blinks, using a model created with MediaPipe and Deep Learning techniques.
 
Theoretical Framework: The research is based on concepts of eye position tracking, convolutional networks and media pipe technology, with a focus on applying it to the communication needs of people with speech difficulties.
 
Method: Qualitative and exploratory study, convolutional networks and media pipe techniques were used. To create the dataset, web scraping techniques were combined with manual image collection, the model was trained by comparing the performance of two CNN architectures.
 
Results and Discussion: The incorporation of AI in the eye blink detection process is relatively recent, with more publications since 2020. It was found that the system is capable of processing facial gestures in real time with an average delay of 0.5 seconds, users reported improvements in their ability to communicate independently and reducing the effort their relatives had to make to interpret their needs, an accuracy of 94.5% was achieved in standard lighting conditions and 92% in variable conditions.
 
Research Implications: The research reveals how AI with the incorporation of continuously emerging methods can improve the task of detecting images for eye tracking, obtaining increasingly better results in precision.
 
Originality/Value: The application of emerging AI techniques in eye tracking to apply it in the development of a system that helps people with speech problems communicate.
#051 Doença de Behçet: lesões orais no diagnóstico de doença sistémica
Authors:   ULS de São José, Ferreira Catarina , Vital Catarina ,   ULS de São José, Cruz João ,   ULS de São José, Barros Cristina ,   ULS de São José, Figueiredo Luísa ,   ULS de São José, Leite Paula ,   ULS de São José
Published: January 2025

Introdução: A doença de Behçet (DB) é uma doença inflamatória sistémica de causa desconhecida, caracterizada por sintomas como: úlceras orais, úlceras genitais, uveíte e envolvimento articular. Considerada uma vasculite de vasos variáveis, apresenta fases sucessivas de exacerbações e remissões. O seu pico de incidência situa-se entre a terceira e quarta décadas de vida, tendo uma distribuição igual entre sexos. As lesões mucocutâneas são consideradas um marco desta doença, antecedendo as restantes manifestações, pelo que o seu reconhecimento pode permitir um diagnóstico e tratamento mais precoces com um melhor prognóstico. Descrição do Caso Clínico: Mulher caucasiana, 70 anos, com antecedentes de artrite reumatóide, tromboembolismo pulmonar crónico e vasculite retiniana, medicada habitualmente com metotrexato, apixabano, metilprednisolona e fluoxetina. Referia úlceras orais recorrentes, dolorosas e hemorrágicas, desde há vários anos, com episódio persistente nos últimos 6 meses. Medicada com nistatina, mas sem melhoria. Esporadicamente, apresentava igualmente úlceras genitais dolorosas. À observação intraoral as úlceras apresentavam halo eritematoso, situando-se na região retrocomissural labial e mucosa jugal direitas. No estudo analítico apresentava apenas anticorpos antinucleares positivos, tendo sido excluídas doenças infeciosas e outras doenças autoimunes. O teste de patergia cutâneo e a pesquisa do alelo HLA-B51 revelaram-se positivos. De acordo com os critérios de diagnóstico do ICBD, apresentava um score 7, pelo que se considerou o diagnóstico de DB. Em colaboração com a Reumatologia, realizou-se ajuste de terapêutica imunossupressora e apresentou melhoria dos sintomas. Discussão e Conclusões: A DB apresenta-se como um desafio diagnóstico uma vez que não existe um teste laboratorial patognomónico universalmente reconhecido, baseando-se principalmente em critérios clínicos após a exclusão de um diagnóstico alternativo. Apresenta uma gravidade variável, consoante os órgãos que envolve, contudo é uma doença com uma morbilidade significativa. O seu tratamento baseia-se no alívio sintomático, na prevenção de complicações sérias e na diminuição das exacerbações, tentando prolongar os períodos de remissão. No caso apresentado, foi possível um diagnóstico em fase inicial da doença, através da identificação das lesões mucocutâneas, e controlo sintomático, gerindo a terapêutica de acordo com a vigilância apertada dos sintomas.
Retos actuales para el aprendizaje y gestión del conocimiento en las Administraciones públicas. Estudio de caso del Modelo de Aprendizaje y Desarrollo (MAD) de la Escola d’Administració Publica de Catalunya y su implementación
Authors: Martínez-Simón Sílvia
Published: January 2025

Objetivos: el presente artículo se orienta a analizar los retos del aprendizaje y la gestión del conocimiento en el contexto de la Administración pública, y a exponer los conceptos y ejes clave a partir de los cuales articular nuevos modelos orientados a su transformación. Este estudio se enfoca en el análisis y descripción del Modelo de Aprendizaje y Desarrollo (MAD) de la Escola d’Administració Pública de Catalunya (EAPC) y profundiza en cómo se está llevando a la práctica. Metodología: el valor principal de este artículo radica en su enfoque orientador y asesor. Resultados: un modelo que se alinea con la cultura colaborativa debía cocrear su implementación, por lo que se describe el proceso de elaboración del plan de implementación del MAD. Mediante el mismo, se están desarrollando actuaciones que abordan distintos ejes críticos para que la transformación sea efectiva y se impulse el cambio, como la transformación y gestión del cambio, la gobernanza, la gestión y transferencia de conocimiento, los instrumentos y herramientas, la comunicación y evaluación. Conclusiones: con el análisis planteado en este estudio se pretende que el ecosistema del aprendizaje y desarrollo en las Administraciones públicas pueda transferir las bondades de este modelo y, asimismo, sea crítica con él, con el objetivo de que se provoquen mejoras en la preparación de los servidores públicos para asumir nuevos retos, impacte en su desarrollo profesional y contribuya a la mejora de los servicios públicos.
Revictimización de familiares de miembros de la fuerza pública víctimas de desaparición forzada
Authors: Páez Rojas Yesika Manuela , Urrea Basto Yadira Tatiana
Published: January 2025

Este estudio, hecho con un enfoque cualitativo y entrevistas semiestructuradas, se propone analizar los relatos de familiares de miembros de la fuerza pública víctimas de desaparición forzada en el marco del conflicto armado interno. Desde un enfoque psicojurídico, esta investigación identifica algunos factores revictimizantes que enfrentan estas familias en su proceso de reconocimiento e implementación de los derechos que tienen como víctimas según la Ley 1448 de 2011. Además de observar el daño psicológico que enfrentan las familias al sufrir este crimen de lesa humanidad, se evidencian las fallas que las revictimizan en el proceso de toma de declaraciones, la falta de acompañamiento y apoyo, y la minimización de la vulneración de sus derechos por tratarse de miembros de la fuerza pública.
Viscerālā estētika: afekti un feministiskā māksla postsociālismā
Authors:   Rīgas Stradiņa universitāte, Kukaine Jana ,   LU Literatūras, folkloras un mākslas institūts
Published: January 2025

Grāmata piedāvā pētīt feministisko mākslu postsociālismā viscerālās estētikas skatījumā. Smeļoties afektu un ķermeņa teoriju, kā arī postsociālisma studiju atziņas, autore pievēršas feministiskā jutīguma atstātajām viscerālajām nogulsnēm Centrālās Eiropas un Austrumeiropas mākslas vēsturēs un teorijās. Šie atradumi ļauj izkopt kritisko vārdnīcu un formulēt pētniecisku pozīciju, kuras centrā ir ikdienas dzīvotā pieredze un tās politiskie aspekti. Grāmata veicina izpratni par feministisko mākslu un iepazīstina lasītāju ar tās dažādajiem ritmiem un plūsmām.
Monogrāfija izdota ar LU LFMI Zinātniskās padomes 2023. gada 25. oktobra sēdes lēmumu.
Monogrāfija publicēta ar Valsts kultūrkapitāla fonda atbalstu.
Assessment of Iranian Intensive Care Nurses’ Perception of Futile Care
Authors: Mehrabi Alireza , Taebi Mozhgan , Bagherian Behnaz
Published: January 2025

This study aimed to evaluate the perceptions of ICU nurses regarding futile care in hospitals affiliated with Kerman University of Medical Sciences in 2018. The research specifically targeted nurses working in the ICU departments of these hospitals who held at least a bachelor’s degree. The questionnaire used in the study consisted of eight questions related to nurses’ views on futile care in the ICU. Additionally, the questionnaire included a section that explored nurses’ perspectives on the causes of futile care and its persistence, covering topics such as communication, information exchange, respect for patient preferences, involvement in decision-making, and quality of patient care. Non-normal data distribution led to the use of the Mann-Whitney U and Kruskal-Wallis tests to analyse the relationship between nurses’ perceptions of futile care, its causes, and various nurse-related factors. The study involved 236 ICU nurses who met the inclusion criteria, with 179 nurses participating in the research. The average age of the nurses was 32.78 ± 6.50 years. The results indicated a significant correlation between nurses’ perception scores of futile care and their views on the causes and dimensions of futile care (r = 0.65, p < 0.001). Further research is recommended to gain a deeper understanding of ICU nurses’ perceptions and experiences related to futile care.
FAMILY SARCOIDOSIS CASE REPORT
Authors:   Grodno State Medical University, Grodno, Belarus, Demidik S. N. , Surmach K. M. ,   Grodno State Medical University, Grodno, Belarus, Frolov V. A. ,   Grodno Clinical Hospital No.3, Grodno, Belarus, Artsymenia L. T. ,   Grodno Clinical Hospital No.3, Grodno, Belarus, Zayats Y. U. ,   Grodno Clinical Hospital No.3, Grodno, Belarus
Published: January 2025

Sarcoidosis is a multisystemic disease with the formation of granulomas in different organs. The impact of environmental factors on a genetically predisposed organism leads to the development of the disease. Candidate genes for determining the phenotype of the disease have been identified. The identification of family sarcoidosis cases confirms the role of genetic factors. Family relative risks and clinical phenotypes may differ between ethnic groups and require further studies. The presented clinical case draws attention for proper history taking to clarify the family predisposition for disease, to analyze family medical records, to perform high-resolution computed tomography in patients. This algorithm can help to identify pathological changes. Every case requires morphological confirmation of the diagnosis. The case is discussed from the standpoint of personalized medicine and up-to-date clinical recommendations.
TAKAYASU ARTERITIS: CLINICAL CASE OF EARLY DIAGNOSIS IN GENERAL MEDICAL PRACTICE
Authors:   Grodno State Medical University, Grodno, Belarus, Kezhun L. V. , Yakubоva L. V. ,   Grodno State Medical University, Grodno, Belarus, Zaretskaya S. T. ,   City Polyclinic No. 6, Grodno, Belarus, Bahamaz Y. I. ,   City Polyclinic No. 6, Grodno, Belarus
Published: January 2025

Summary. We describe a clinical case of asymptomatic Takayasu arteritis, which was timely suspected and diagnosed in an outpatient setting, in a 29-year-old female patient with anemic syndrome and accelerated ESR syndrome. The diagnostic examination revealed the absence of pulse in the left upper limb, a difference of more than 10 mm Hg in blood pressure measured on the right and left arms, stenosis of more than 80% of the first segment of the left subclavian artery according to duplex scanning of the extracranial sections of the brachiocephalic arteries, signs of Takayasu arteritis as revealed by computed tomography. The patient was hospitalized in the rheumatology department of the Grodno University Clinic with further confirmation of the diagnosis and prescription of immunosuppressive, anti-inflammatory and antiplatelet therapy.
The relationship of hyperuricemia with arterial hypertension and risk factors for cardiovascular diseases in the working population of South Yakutia
Authors:   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Ru, Sofronova S.I.
Published: January 2025

A one-stage population study was conducted in the working population in south Yakutia. The 174 people of non-indigenous nationality were examined. Increased uric acid (UA) levels were found in 27% of the individuals. The association of UA level with BMI, OT, lipid spectrum was revealed mainly in men, systolic blood pressure and blood glucose in women. Abdominal obesity was equally frequently recorded in both men and women, regardless of the presence or absence of hyperuricemia, Logistic regression showed satisfactory information content of the prognostic significance of the level of UA with hypertension only in the female population. Hyperuricemia was not an independent risk factor for the development of cardiovascular pathology.
Keywords: uric acid, hypertension, obesity, lipid spectrum, non-indigenous population, south Yakutia.
Evaluation of competitive endurance of airborne troops participating in the all-army competition "Airborne Platoon" according to the analysis of heart rate variability
Authors:   Candidate of Pedagogical Sciences, Associate Professor, Military Institute of Physical Training, St. Petersburg, Arzhakov V.V. , Kuznetsov V.D. ,   Candidate of Pedagogical Sciences, Military Institute of Physical Training, St. Petersburg, Gritsenko A.Ya. ,   assistant to the commander of the regiment for physical training,  head of the physical training unit 32515 Airborne troops, Pskov
Published: January 2025

The article presents the results of a study of the competitive endurance of servicemen of the airborne troops performing at the 3rd stage of the military field training competition "Airborne Platoon". The relevance of the work lies in the fact that a timely assessment of the functional state of military athletes will make it possible to adjust training plans in time and perform more effectively at the competition. The aim of the study was to assess the competitive endurance of military athletes according to heart rate variability data with different military accounting specialties. Based on the data of heart rate variability, the analysis of the state of the regulatory processes of the body was carried out, the assessment of the competitive endurance of the airborne troops before and after performing special tasks in the "Airborne Platoon" military field training competition was carried out. With the help of an orthostatic test, the latent capabilities of the functional systems of the body were evaluated. The body of military personnel serving as driver mechanics is characterized by a pronounced tension of regulatory systems during the orthostatic test, in soldiers of other accounting specialties, the body reacts adequately. It is presented that the physical load during the period of the competition was at the limit of the capabilities of the body of military personnel and almost led to the breakdown of adaptation mechanisms.
Keywords: heart rate variability, military athletes, physical fitness, military field training competition "Airborne Platoon".
Congenital autosomal recessive cataract in a Sakha child
Authors:   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Ru, Savvina M.S. , Ivanova O.N. ,   MD, Professor of the Department of Pediatrics and Pediatric Surgery, M.K. Ammosov NEFU, Medical Institute, Egorova V.B. ,   PhD, Associate Professor of the Department of Pediatrics and Pediatric Surgery, M.K. Ammosov NEFU, Medical Institute, Burtseva T.E. ,   MD, Professor of the Department of Pediatrics and Pediatric Surgery, M.K. Ammosov NEFU, Medical Institute; Head of the laboratory of the YSC KMP
Published: January 2025

The article presents a clinical case of congenital autosomal recessive cataract, first identified in a 3-year-old Sakha child. Congenital cataract is a relatively rare pathology found in children, but it is often the cause of visual impairment and blindness. The restoration of a child's eyesight depends on the early detection and treatment of the disease. Studies show that 30 to 50% of congenital cataracts are caused by genetic mutations.
Keywords: congenital cataracts, child, malformation, genetics.
ИНТЕЛЛЕКТУАЛЬНАЯ СИСТЕМА ФИЛЬТРАЦИИ НЕЖЕЛАТЕЛЬНОЙ ИНФОРМАЦИИ НА ОСНОВЕ ГЛУБОКОГО ОБУЧЕНИЯ
Authors: ВЛАСЮК Н А. , КАЛКОВ Д Ю. , ТОЛСТЫХ М Ю.
Published: January 2025

Рассматривается применение технологий искусственного интеллекта для решения задачи фильтрации спам-сообщений. Основное внимание уделяется разработке системы, способной автоматически классифицировать текстовые данные на спам и не спам, используя методы глубокого обучения. Описывается процесс подготовки и предобработки данных, включающий очистку, балансировку классов и преобразование текста в подходящий для обучения формат. Анализ полученных результатов демонстрирует высокую точность и эффективность предложенной системы в задаче фильтрации спама. Подход может быть применен в областях, где требуется обработка и анализ больших объемов текстовой информации.

The application of artificial intelligence technologies to solve the problem of filtering spam messages is considered. The focus is on developing a system that can automatically classify text data into spam and non-spam using deep learning techniques. The process of preparing and preprocessing data is described, including cleaning, class balancing, and converting text into a format suitable for training. Analysis of the results obtained demonstrates high accuracy and efficiency.
ОЦЕНКИ ОТДЕЛЬНЫХ АСПЕКТОВ СОЦИАЛЬНО-ЭКОНОМИЧЕСКОЙ СИТУАЦИИ НА СЕВЕРЕ РФ И В РОССИЙСКОЙ АРКТИКЕ В УСЛОВИЯХ ГЛОБАЛЬНЫХ ВЫЗОВОВ И РИСКОВ
Authors: Гущина И.А. , Кондратович Д.Л. , Положенцева О.А.
Published: January 2025

В основе данной статьи  результаты многолетних исследований  условий и факторов социально-экономического развития местных сообществ северных и арктических регионов РФ. Целью работы является определение степени влияния и возможностей снижения негативных последствий антироссийских санкций, включая импортозамещение, на процессы социально-экономического развития муниципальных образований  северных и арктических регионов РФ в условиях расширения глобальной конфронтации и связанных с этим социальных и экономических рисков. Использован метод социологического анализа: по результатам трех экспертных опросов в 2022-2024 гг., на основе экспертных оценок представителей муниципальной власти  указанных регионов и ученых, занимающихся исследованиями в социально- экономической сфере, определены направления экономической деятельности, понесшие, в той или иной степени, ущерб в результате санкционного давления; определены оценки успешности решения вопросов импортозамещения. Выявлено снижение изначально негативных ожиданий, зафиксированных по результатам экспертных опросов предыдущих лет, по таким показателям как рост цен, ухудшение качества и уровня жизни населения, сокращение ассортимента различных видов продукции. Показана возможность  использования экспертных оценочных мнений при разработке и корректировке муниципальных и региональных планов и программ развития.
Application of Occupational Health and Safety Management through Job Safety Analysis in Steel Structure Installation: A Case Study of the P.T. Ultra Sakti Workshop Construction
Authors: Putra Alfandias Seysna , Ramdan Muhammad , Putri Isria Miharti Maherni
Published: January 2025

Workplace accidents are a prevalent issue across various construction projects, including workshop development. To address this challenge, the implementation of Occupational Health and Safety (OHS) management is crucial. This study aims to evaluate the application of OHS management, with a focus on the utilization of Job Safety Analysis (JSA) methods to prevent workplace accidents during workshop construction projects. The research employs a qualitative field study approach. Data were collected through direct observations, interviews with workers, project managers, and Health, Safety, and Environmental (HSE) personnel, as well as through the analysis of relevant OHS documentation. The JSA implementation process was assessed at various stages, including hazard identification, control measure determination, and the implementation of preventive actions. The findings reveal that the average risk level associated with steel structure installation work is classified as moderate, with a percentage of 51%. Activities that present high to extreme risk levels are predominantly related to tasks performed at height, such as the installation of main beams, secondary beams, and rafters, with fall and impact hazards being significant concerns. To mitigate these risks, appropriate controls must be enforced, including the use of Personal Protective Equipment (PPE), full-body harnesses, effective housekeeping practices, and the installation of signage and the isolation of hazardous work areas. These measures can effectively reduce risk levels from high and extreme to low and moderate.
Ensuring competitiveness in the XXI century: use of management tools in the internet-economy (on the example of banks)
Authors: Madyarov A. A.
Published: January 2025

The formation of the Internet economy places special demands on the development of a system of organisational influences used to solve problems of adaptation to changes in the external environment and internal integration. At the same time, the effectiveness of the updated combination of management tools should be sufficient to ensure competitiveness during the implementation of the strategic process. The relevance of studying and systematising the practices used by the subjects of the digital economy is justified by the transformational processes of the information society, representing both scientific and practical interest. Consideration of the works of leading Russian and foreign scientists specialising in the development of the Internet economy through the use of the management tools as well as the results of the People’s rating of customer service by domestic banks allows us to draw conclusions about the need to introduce special approaches to respond to the challenges the threats of the latest strategic context. In addition, they should be combined considering the results of the analysis and systematisation of this study. The article concludes with brief findings on the results of the research, emphasising the importance of continuing to study examples of ensuring the competitiveness by Russian companies in the XXI century: identifying industry features may be of interest for replicating best practices in the Internet economy.
State and trends of regulation of crypto assets and cryptocurrency exchanges
Authors: Kitinov M. B.
Published: January 2025

This article analyses the current state and trends in the regulation of trading of crypto assets and crypto exchanges at the global level. The enacted laws and regulations of the jurisdictions of the United States of America (herein-after referred to as USA) and the European Union (hereinafter referred to as EU) are indicated. It is emphasised that the regulatory framework of the EU is an example of effective international regulation. It is noted that the legislation in the USA regarding the regulation of the crypto exchanges and crypto assets is at the development stage, and there are contradictions between authorities considering the scope of the necessary regulation. The steps that should be taken at the global level to harmonise regulatory standards are analysed. The key directions for the development of the global regulation of the crypto exchanges include expansion of requirements to combat money laundering and financing of terrorism, introduction of mechanisms for training and protecting investors and information disclosure requirements. The author emphasises the need for interaction between industry representatives and regulators to manage the risks associated with cryptocurrencies, including prevention of market manipulation and fraud. The results of the work will be useful in shaping the concepts of the national and global regular framework regarding the trading of the crypto assets. Methods of analysis, synthesis, formal-logical, comparative, and descriptive analysis have been used as research methods.
Features of reproductive behaviour of students on the example of the Tambov region of the Russian Federation
Authors: Filippenko V. A.
Published: January 2025

The article provides an analysis of the demographic situation in the Tambov region and regional policy on this issue. There is a difficult demographic situation in the entity under consideration. Based on the results of the sociological study of the student youth of the region, a high degree of importance of self-realisation, self-development, and achievement of material well-being is revealed. The creation of a family becomes less important in the life goals of the student youth. The dependence of the respondents’ reproductive plans on their idea of what life will be like. The more confident young people are in life success, the more confident they are about having children. A person’s commitment to religion can have a strong impact in the case of unplanned pregnancy and the decision to have an abortion. For a more complete realisation of the possibilities of reproductive behaviour of the young people, it is necessary to develop measures of both regional and federal support, since these measures can have a positive impact on the factor of confidence in the future and also that in the case of a difficult life situation, a young family will always have the opportunity to ask someone for help. In addition, it is especially important to form ideas about the possibility of successfully combining parental responsibilities, self-realisation and career building. For a deeper understanding of these processes, it is necessary to continue studying this issue.
Strengthening the technological sovereignty of the Russian oil and gas industry in the context of turbulent geopolitics in the world
Authors: Linnik V. Yu. , Laznik A. A. , Gordeeva T. S.
Published: January 2025

Every year, the energy sector of the Russian Federation (hereinafter referred to as RF) is faced with the emergence of new restrictions from other states that hinder its strengthening. After the introduction of a number of regular packages of sanctions by Western countries and the United States of America against the RF, implying a ban on a large number of supplies of equipment and technologies to the oil and gas industry, it becomes obvious that there is a need for domestic developments. In the current geopolitical situation, domestic oil and gas companies have the opportunity to expand their markets, create new areas of activity in the form of production of their own equipment and technologies in the field of drilling oil and gas wells on land and at sea, extraction of hydrocarbon resources, information technologies with the prospect of reaching the international level.

   The purposes of this study are to analyse the policy of strengthening the sovereignty of the Russian oil and gas industry over the past 10 years and identify key areas for its further development.

   Also, within the framework of this article, the main domestic companies that have succeeded in developing their own technologies and equipment are identified, possible threats hindering the implementation of import substitution policy are found, and possible solutions are proposed.
Further SAR of GIRK1/2 positive allosteric modulators: Synthesis and Biological Characterization of In Vitro Tool Compounds
Authors: Nahid Sumaiya , Rahman Fahad , Du Yu , Spitznagel Brittany , Singh Sandeep , Chhonker Yashpal , Murry Daryl , Weaver C. David , Hopkins Corey
Published: January 2025

The work presented herein outlines the ongoing structure-activity relationship (SAR) studies centered around a potent, efficacious, and selective positive allosteric modulators (PAM) of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N-1-position of the pyrazole and the right-hand ether. The work confirmed the necessity of the pyrazole, and we have identified a more potent GIRK1/2 activator with ~12-fold selectivity against GIRK1/4. We also report the metabolite ID study which shows the instability of the amide bond as the major site of metabolism (non-NADPH mediated). This work discovered another highly potent and selective GIRK1/2 activator for use as an in vitro tool compound.