bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifying Illicit Drug Dealers on Instagram with Large-scale Multimodal Data Fusion
Authors: Hu Chuanbo , Yin Minglei , Liu Bin , Li Xin , Ye Yanfang
Published: September 2021

Illicit drug trafficking via social media sites such as Instagram have become a severe problem, thus drawing a great deal of attention from law enforcement and public health agencies. How to identify illicit drug dealers from social media data has remained a technical challenge for the following reasons. On the one hand, the available data are limited because of privacy concerns with crawling social media sites; on the other hand, the diversity of drug dealing patterns makes it difficult to reliably distinguish drug dealers from common drug users. Unlike existing methods that focus on posting-based detection, we propose to tackle the problem of
illicit drug dealer identification
by constructing a large-scale multimodal dataset named
Identifying Drug Dealers on Instagram
(IDDIG). Nearly 4,000 user accounts, of which more than 1,400 are drug dealers, have been collected from Instagram with multiple data sources including post comments, post images, homepage bio, and homepage images. We then design a quadruple-based multimodal fusion method to combine the multiple data sources associated with each user account for drug dealer identification. Experimental results on the constructed IDDIG dataset demonstrate the effectiveness of the proposed method in identifying drug dealers (almost 95% accuracy). Moreover, we have developed a hashtag-based community detection technique for discovering evolving patterns, especially those related to geography and drug types.
Optical Aberrations Correction in Postprocessing Using Imaging Simulation
Authors: Chen Shiqi , Feng Huajun , Pan Dexin , Xu Zhihai , Li Qi , Chen Yueting
Published: September 2021

As the popularity of mobile photography continues to grow, considerable effort is being invested in the reconstruction of degraded images. Due to the spatial variation in optical aberrations, which cannot be avoided during the lens design process, recent commercial cameras have shifted some of these correction tasks from optical design to postprocessing systems. However, without engaging with the optical parameters, these systems only achieve limited correction for aberrations.

In this work, we propose a practical method for recovering the degradation caused by optical aberrations. Specifically, we establish an imaging simulation system based on our proposed optical point spread function model. Given the optical parameters of the camera, it generates the imaging results of these specific devices. To perform the restoration, we design a spatial-adaptive network model on synthetic data pairs generated by the imaging simulation system, eliminating the overhead of capturing training data by a large amount of shooting and registration.

Moreover, we comprehensively evaluate the proposed method in simulations and experimentally with a customized digital-single-lens-reflex camera lens and HUAWEI HONOR 20, respectively. The experiments demonstrate that our solution successfully removes spatially variant blur and color dispersion. When compared with the state-of-the-art deblur methods, the proposed approach achieves better results with a lower computational overhead. Moreover, the reconstruction technique does not introduce artificial texture and is convenient to transfer to current commercial cameras. Project Page:
https://github.com/TanGeeGo/ImagingSimulation
.
Lessons Learned: Analysis of PUF-based Authentication Protocols for IoT
Authors: Lounis Karim , Zulkernine Mohammad
Published: September 2021

The service of authentication constitutes the spine of all security properties. It is the phase where entities prove their identities to each other and generally establish and derive cryptographic keys to provide confidentiality, data integrity, non-repudiation, and availability. Due to the heterogeneity and the particular security requirements of IoT (Internet of Things), developing secure, low-cost, and lightweight authentication protocols has become a serious challenge. This has excited the research community to design and develop new authentication protocols that meet IoT requirements. An interesting hardware technology, called PUFs (Physical Unclonable Functions), has been the subject of many subsequent publications on lightweight, low-cost, and secure-by-design authentication protocols. This has turned our attention to investigate the most recent PUF-based authentication protocols for IoT. In this article, we review the security of these protocols. We first provide the necessary background on PUFs, their types, and related attacks. Also, we discuss how PUFs are used for authentication. Then, we analyze the security of PUF-based authentication protocols to identify and report common security issues and design flaws, as well as to provide recommendations for future authentication protocol designers.
From the Editor: The Wonder of Science
Authors: Kelly Rob
Published: September 2021

Just when we thought it was safe to go back in the water, the Delta variant comes along. Its spread has caused ECS to make the 240th Meeting all digital. I was really looking forward to cashing in on some promises of “I’ll buy you a beer the next time we get together.” My friends should know that compound interest on those continues to accumulate. As we hunker back down, it is appropriate to stop and recognize the almost unimaginable scientific achievement that has led the world away from cataclysm and back toward normality. The speed with which the vaccines have been developed would have been considered science fiction before it actually happened.
How to Maximize the Value Recovered from Li-Ion Batteries: Hydrometallurgical or Direct Recycling?
Authors: Gaines Linda , Wang Yan
Published: September 2021

Although the US has minimal reserves of the raw materials needed to make EV batteries, EOL material can contribute to domestic supply. However, this valuable resource will be exported if it is not economical to recycle it here. Hydrometallurgical recycling plants are being built now, with the expectation that they will be profitable, but profits will decline with cobalt content. By the time that happens, direct recycling will be sufficiently developed to take up the slack. Both processes will then be available to upgrade recovered materials to more up-to-date chemistries, securing a domestic supply of these materials.
Circular Economy of Polymers - Electrochemical Recycling and Upcycling
Authors: Karuppalah Chockkalingam , Vasiljevic Natasa , Chen Zheng
Published: September 2021

Our society depends on fossil-based resources for energy needs and feedstocks to make many synthetic organic materials, i.e., polymers. Synthetic polymers from fossil resources amount to over 440 million metric tons annually, and are expected to reach 700 million metric tons by 2030. About 20% of discarded synthetic polymers are recycled globally, about 25% are incinerated, and the balance are added to landfill. While some energy is recuperated through incineration, the overall impact of today’s linear economy principles of “make, use and mostly discard” approach impacts both local and global environment negatively. An alternative to this is a circular economy principle which aims at restructuring the way we think of design, manufacturing, consumption, and waste. By employing circular economy principles, the feedstock for new synthesis will originate from discarded and recycled polymers after their useful life.
Ubiquitin ligase Wwp1 gene deletion attenuates diastolic dysfunction in pressure-overload hypertrophy
Authors: Snyder Laura B. , Lai Yimu , Doviak Heather , Freeburg Lisa A. , Laney Valerie K. , Moore Amber , Zellars Kia N. , Matesic Lydia E. , Spinale Francis G.
Published: September 2021

Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and is accompanied by abnormal extracellular matrix (ECM) accumulation. It is now recognized that the ECM is a dynamic entity that is regulated at multiple post-transcriptional levels, including the E3 ubiquitin ligases, such as WWP1. In the present study, WWP1 deletion in the context of an LVPO stimulus reduced functional indices of HFpEF progression and determinants of ECM remodeling. Understanding and targeting the ubiquitin ligases in the context of HFpEF forms an important research direction.
Intrusion Detecting System Based on Temporal Convolutional Network for In-Vehicle CAN Networks
Authors: Shi Dongxian , Xu Ming , Wu Ting , Kou Liang
Published: September 2021

In recent years, deep learning theories, such as Recurrent Neural Networks (RNN) and Convolutional Neural Networks (CNN), have been applied as effective methods for intrusion detection in the vehicle CAN network. However, the existing RNNs realize detection by establishing independent models for each CAN ID, which are unable to learn the potential characteristics of different IDs well, and have relatively complicated model structure and high calculation time cost. CNNs can achieve rapid detection by learning the characteristics of normal and attack CAN ID sequences and exhibit good performance, but the current methods do not locate abnormal points in the sequence. To solve the above problems, this paper proposes an in-vehicle CAN network intrusion detection model based on Temporal Convolutional Network, which is called Temporal Convolutional Network-Based Intrusion Detection System (TCNIDS). In TCNIDS, the CAN ID is serialized into a natural language sequence and a word vector is constructed for each CAN ID through the word embedding coding method to reduce the data dimension. At the same time, TCNIDS uses the parameterized Relu method to improve the temporal convolutional network, which can better learn the potential features of the normal sequence. The TCNIDS model has a simple structure and realizes the point anomaly detection at the message level by predicting the future sequence of normal CAN data and setting the probability strategy. The experimental results show that the overall detection rate, false alarm rate, and accuracy rate of TCNIDS under fuzzy attack, spoofing attack, and DoS attack are higher than those of the traditional temporal convolutional network intrusion detection model.
The Multiple Roles of Trogocytosis in Immunity, the Nervous System, and Development
Authors: Uribe-Querol Eileen , Rosales Carlos
Published: September 2021

Trogocytosis is a general biological process that involves one cell physically taking small parts of the membrane and other components from another cell. In trogocytosis, one cell seems to take little “bites” from another cell resulting in multiple outcomes from these cell‐cell interactions. Trogocytosis was first described in protozoan parasites, which by taking pieces of host cells, kill them and cause tissue damage. Now, it is known that this process is also performed by cells of the immune system with important consequences such as cell communication and activation, elimination of microbial pathogens, and even control of cancer cells. More recently, trogocytosis has also been reported to occur in cells of the central nervous system and in various cells during development. Some of the molecules involved in phagocytosis also participate in trogocytosis. However, the molecular mechanisms that regulate trogocytosis are still a mystery. Elucidating these mechanisms is becoming a research area of much interest. For example, why neutrophils can engage trogocytosis to kill Trichomonas vaginalis parasites, but neutrophils use phagocytosis to eliminate already death parasites? Thus, trogocytosis is a significant process in normal physiology that multiple cells from different organisms use in various scenarios of health and disease. In this review, we present the basic principles known on the process of trogocytosis and discuss the importance in this process to host‐pathogen interactions and to normal functions in the immune and nervous systems.
Value of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Red Blood Cell Distribution Width in Evaluating the Prognosis of Children with Severe Pneumonia
Authors: Qi Xuejiao , Dong Yihui , Lin Xiaojie , Xin Wencheng
Published: September 2021

Objective. To investigate the value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and red blood cell distribution width (RDW) in evaluating the prognosis of children with severe pneumonia (SP). Methods. A retrospective analysis of the data of 91 children with SP admitted to our hospital from March 2018 to March 2021. According to the survival status after 28 days of treatment, all children were divided into the survival group (n = 59) and the death group (n = 32). The clinical data and laboratory indicators of the patients were recorded. Multivariate logistic regression was used to analyze the risk factors of prognosis, and the ROC curve was used to analyze the predictive value of each index. Results. The Acute Physiology and Chronic Health Evaluation II (APACHE II) score and CURB-65 score of the death group were higher than those of the survival group (

P
<
0.05

). The RDW, NLR, PLR, and high-sensitivity C-reactive protein, procalcitonin blood lactic acid (Lac) of the death group, were higher than those of the survival group, and LYM was lower than the survival group (

P
<
0.05

). Multivariate regression analysis showed that APACHE II score, RDW, NLR, PLR, and Lac were all independent risk factors for poor prognosis in children with SP (

P
<
0.05

). The AUC of NLR, PLR, and RDW for evaluating the prognosis of children with SP were 0.798, 0.781, and 0.777, respectively. The sensitivity was 56.25%, 90.63%, and 56.25%, respectively, and the specificity was 89.83%, 55.93%, and 91.53%, respectively. The AUC of NLR, PLR, and RDW combined to evaluate the prognosis of children with SP was 0.943. When the best cut-off value was 0.8528, the sensitivity was 93.75%, and the specificity was 91.53%. Conclusion. NLR, PLR, and RDW have certain predictive value for the prognosis of children with SP; the combination of the three indicators has a higher value in evaluating the prognosis of children with SP, which can better guide the prognostic treatment.
The Bridge between Screening and Assessment: Establishment and Application of Online Screening Platform for Food Risk Substances
Authors: Hu Kang , Jin Shaoming , Ding Hong , Cao Jin
Published: September 2021

In order to improve the risk identification ability of the technical support system of food safety supervision, an online screening platform for food risk substances (hereafter referred to as “platform”) was established. The platform aims at the qualitative analysis of unknown compounds and consists of three parts: a standard spectrum library, screening model, and online comparison module. The standard library contains the standard spectra of 527 food risk substances by high-performance liquid chromatography/high-resolution mass spectrometry. The screening comparison algorithm, the core of the screening model, is obtained through the improvement of the existing spectral library search algorithm. The inspector uploads the original spectrum file through the online comparison module; the online comparison module calls the corresponding script to convert the original spectrum file into a standard spectrum file and then uses the screening and comparison algorithm to achieve online real-time comparison. The comparison results are used to determine whether the sample to be tested contains the food risk substances contained in the standard library, so as to realize the preliminary screening of potential food risk substances. The platform supports the spectrogram data format of mainstream instrument manufacturers. The standard spectrogram database can be coconstructed and shared by cooperative laboratories to effectively enrich the types of food risk substances. Through laboratory comparison, data calibration, and model optimization, the screening accuracy of the platform can reach more than 97%. The platform adopts the Internet online screening method, which greatly facilitates the risk investigation and control of national food safety inspection and testing institutions. At the same time, the construction of the screening platform for food risk substances based on high-performance liquid chromatography/high-resolution mass spectrometry, the Internet, big data, and other technologies will provide a new technical means for food safety risk management and control. Hence, it can build a bridge between the screening of risk substances and illegally added substances, as well as risk assessment, risk management, and control.
Synthesis, Radiolabeling, and Biological Evaluation of 68Ga-Mucin1 and Its Folate Hybrid Peptide Conjugates for the Diagnosis of Ovarian Cancer
Authors: Alhabardi Samiah , Radwan Hesham , Alotaibi Basim , Almalki Yousif , Elzayat Ehab , Shinwari Zakia , Okarvi Subhani M. , Aljammaz Ibrahim
Published: September 2021

Because of our interest in developing new hybrid peptide radioconjugates with suitable biochemical properties for multiple-receptors targeting properties that are overexpressed on many human cancers especially ovarian cancer, we have synthesized 68Ga-NODAGA-MUC1 and 68Ga-NODAGA-MUC1-FA hybrid peptide conjugates using a straightforward and one-step simple reaction. Radiochemical yields were found to be higher than 95% (decay corrected), with a total synthesis time of less than 20 min. Radiochemical purities were always higher than 95% without HPLC purification. In vitro studies on KB cancer cells showed that substantial amounts of the radioconjugates were associated with cell fractions and held great affinities and specificities toward the KB cell line. In vivo characterization in normal female Balb/c mice revealed rapid blood clearance of these radioconjugates with excretion predominantly by the urinary system. Biodistribution studies in nude mice bearing human KB cell line xenografts demonstrated significant tumor uptake and favorable biodistribution profile for 68Ga-NODAGA-MUC1-FA hybrid peptide conjugate compared to the 68Ga-NODAGA-MUC1 peptide monomeric counterpart. The uptake in the tumors was blocked by the excess injection of hybrid peptide, suggesting a receptor-mediated process. These results demonstrate that 68Ga-NODAGA-MUC1-FA hybrid peptide conjugate may be useful as a molecular probe for early detection and staging of folate and MUC1 receptor-positive cancers such as ovarian cancer and their metastasis as well as monitoring tumor response to treatment.
New Approach towards Generalizing Feistel Networks and Its Provable Security
Authors: Liu Jiajie , Sun Bing , Li Chao
Published: September 2021

This paper proposes a new approach to generalizing Feistel networks, which unifies the classical (balanced) Feistel network and the Lai–Massey structure. We call the new structure extended Feistel (E-Feistel) network. To justify its soundness, we investigate its indistinguishability using Patarin’s H-coefficient technique. As a result, it is proved that the 4-round key-alternating E-Feistel (KAEF) cipher with adequately derived keys and identical round functions is secure up to

2

n
/
2

queries, i.e., birthday-bound security. In addition, when adjacent round keys are independent and independent round functions are used, the 6-round KAEF is secure up to beyond-birthday-bound

2

2
n

/
3

queries. Our results indicate that the E-Feistel structure is secure and reliable and can be adopted in designing practical block ciphers.
Effects of IQW and IRW on Inflammation and Gut Microbiota in ETEC-Induced Diarrhea
Authors: Liu Naiyuan , Zhou Lingsi , Fang Jun , Jiang Hongmei , Liu Gang
Published: September 2021

Background/Aims. Changing gut microbiota is one of the most common causes of host gut inflammation. The active triple peptides, lle-Gln-Trp (IQW) and lle-Arg-Trp (IRW), cause remarkable changes to gut microbiota. The effects of the triple peptides IQW and IRW in gut-damage treatment were explored in this study via an enterotoxigenic Escherichia coli- (ETEC-) induced mouse model. Methods. The mice were randomly distributed into four groups: (a) control (CTRL) group, (b) ETEC group, (c) IQW-ETEC group, and (d) IRW-ETEC group. Villus length and crypt depth were measured after hematoxylin and eosin staining. The inflammatory reaction was analyzed via inflammatory cytokines (i.e., TNF-α, IL-1β, IL-6, and IL-10) using the enzyme-linked immunosorbent assay (ELISA). The microbiota in the colon was sequenced using 16S ribosomal RNA. Results. The villus length decreased, the crypt depth decreased, and the expression of inflammatory cytokines (i.e., TNF-α, IL-1β, IL-6, and IL-10) increased due to ETEC. In the IRW-ETEC and IQW-ETEC groups, the Shannon index decreased (

P
<
0.05

). IQW and IRW increased the abundance of Firmicutes, Proteobacteria, Clostridiales, Lachnospiraceae, and Alloprevotella; contrastingly, it decreased the abundance of Epsilonproteobacteria, Erysipelotrichales, Prevotellaceae, and Flavobacteriaceae compared to the ETEC group (P <0.05). Conclusion. This study ascertained that the addition of IQW and IRW could alleviate jejunal inflammation and increase microbiota community diversity.
Emerging Role of Mitophagy in the Heart: Therapeutic Potentials to Modulate Mitophagy in Cardiac Diseases
Authors: Luan Yi , Luan Ying , Feng Qi , Chen Xing , Ren Kai-Di , Yang Yang
Published: September 2021

The normal function of the mitochondria is crucial for most tissues especially for those that demand a high energy supply. Emerging evidence has pointed out that healthy mitochondrial function is closely associated with normal heart function. When these processes fail to repair the damaged mitochondria, cells initiate a removal process referred to as mitophagy to clear away defective mitochondria. In cardiomyocytes, mitophagy is closely associated with metabolic activity, cell differentiation, apoptosis, and other physiological processes involved in major phenotypic alterations. Mitophagy alterations may contribute to detrimental or beneficial effects in a multitude of cardiac diseases, indicating potential clinical insights after a close understanding of the mechanisms. Here, we discuss the current opinions of mitophagy in the progression of cardiac diseases, such as ischemic heart disease, diabetic cardiomyopathy, cardiac hypertrophy, heart failure, and arrhythmia, and focus on the key molecules and related pathways involved in the regulation of mitophagy. We also discuss recently reported approaches targeting mitophagy in the therapy of cardiac diseases.
mRNA Trafficking in the Nervous System: A Key Mechanism of the Involvement of Activity-Regulated Cytoskeleton-Associated Protein (Arc) in Synaptic Plasticity
Authors: Fila Michal , Diaz Laura , Szczepanska Joanna , Pawlowska Elzbieta , Blasiak Janusz
Published: September 2021

Synaptic activity mediates information storage and memory consolidation in the brain and requires a fast de novo synthesis of mRNAs in the nucleus and proteins in synapses. Intracellular localization of a protein can be achieved by mRNA trafficking and localized translation. Activity-regulated cytoskeleton-associated protein (Arc) is a master regulator of synaptic plasticity and plays an important role in controlling large signaling networks implicated in learning, memory consolidation, and behavior. Transcription of the Arc gene may be induced by a short behavioral event, resulting in synaptic activation. Arc mRNA is exported into the cytoplasm and can be trafficked into the dendrite of an activated synapse where it is docked and translated. The structure of Arc is similar to the viral GAG (group-specific antigen) protein, and phylogenic analysis suggests that Arc may originate from the family of Ty3/Gypsy retrotransposons. Therefore, Arc might evolve through “domestication” of retroviruses. Arc can form a capsid-like structure that encapsulates a retrovirus-like sentence in the 3

′

-UTR (untranslated region) of Arc mRNA. Such complex can be loaded into extracellular vesicles and transported to other neurons or muscle cells carrying not only genetic information but also regulatory signals within neuronal networks. Therefore, Arc mRNA inter- and intramolecular trafficking is essential for the modulation of synaptic activity required for memory consolidation and cognitive functions. Recent studies with single-molecule imaging in live neurons confirmed and extended the role of Arc mRNA trafficking in synaptic plasticity.
Aircraft Parking Trajectory Planning in Semistructured Environment Based on Kinodynamic Safety RRT

∗
Authors: Meng Xianglei , Wang Nengjian , Liu Qinhui
Published: September 2021

To improve the safety and effectiveness of autonomous towing aircraft aboard the carrier deck, this study proposes a velocity-restricted path planner algorithm named as kinodynamic safety optimal rapidly exploring random tree (KS-RRT

∗

) to plan a near time-optimal path. First, a speed map is introduced to assign different maximum allowable velocity for the sampling points in the workspace, and the traverse time is calculated along the kinodynamic connection of two sampling points. Then the near time-optimal path in the tree-structured search map can be obtained by the rewiring procedures, instead of a distance-optimal path in the original RRT

∗

algorithm. In order to enhance the planner’s performance, goal biasing scheme and fast collision checking technique are adopted in the algorithm. Since the sampling-based methods are sensitive to their parameters, simulation experiments are first conducted to determine the optimal input settings for the specific problem. The effectiveness of the proposed algorithm is validated in several common aircraft parking scenarios. Comparing with standard RRT

∗

and human heuristic driving, KS-RRT

∗

demonstrates a higher success rate, as well as shorter computation and trajectory time. In conclusion, KS-RRT

∗

algorithm is suitable to generate a near time-optimal safe path for autonomous high density parking in semistructured environment.
Meta-Analysis of the Association Study between Allergic Rhinitis and HLA-II Gene (DQB1) in Northern China
Authors: Wang Jie
Published: September 2021

Objective. To explore the association between allergic rhinitis and HLA-II gene (DQB1) in the Chinese population. Methods. The literature studies related to allergic rhinitis and HLA-II gene (DQB1) in the Chinese population were searched, and those that did not meet the requirements were excluded. The consistency was checked by using RevMan 4.1 software. Results. The HLA-II gene (DQB1) may be a risk gene for patients with allergic rhinitis in Northern China (

P
<
0.01

). Conclusion. Allergic rhinitis in China was associated with the HLA-II gene (DQB1).
Identification of Sitogluside as a Potential Skin‐Pigmentation‐Reducing Agent through Network Pharmacology
Authors: Guo Haoran , Zeng Hongliang , Fu Chuhan , Huang Jinhua , Lu Jianyun , Hu Yibo , Zhou Ying , Luo Liping , Zhang Yushan , Zhang Lan , Chen Jing , Zeng Qinghai
Published: September 2021

Many traditional Chinese medicines (TCMs) with skin‐whitening properties have been recorded in the Ben-Cao-Gang-Mu and in folk prescriptions, and some literature confirms that their extracts do have the potential to inhibit pigmentation. However, no systematic studies have identified the specific regulatory mechanisms of the potential active ingredients. The aim of this study was to screen the ingredients in TCMs that inhibit skin pigmentation through a network pharmacology system and to explore underlying mechanisms. We identified 148 potential active ingredients from 14 TCMs, and based on the average “degree” of the topological parameters, the top five TCMs (Fructus Ligustri Lucidi, Hedysarum multijugum Maxim., Ampelopsis japonica, Pseudobulbus Cremastrae Seu Pleiones, and Paeoniae Radix Alba) that were most likely to cause skin‐whitening through anti‐inflammatory processes were selected. Sitogluside, the most common ingredient in the top five TCMs, inhibits melanogenesis in human melanoma cells (MNT1) and murine melanoma cells (B16F0) and decreases skin pigmentation in zebrafish. Furthermore, mechanistic research revealed that sitogluside is capable of downregulating tyrosinase (TYR) expression by inhibiting the ERK and p38 pathways and inhibiting TYR activity. These results demonstrate that network pharmacology is an effective tool for the discovery of natural compounds with skin‐whitening properties and determination of their possible mechanisms. Sitogluside is a novel skin‐whitening active ingredient with dual regulatory effects that inhibit TYR expression and activity.
5G Joint Artificial Intelligence Technology in the Innovation and Reform of University English Education
Authors: Sun Xia
Published: September 2021

This paper considers the issue of human subjectivity in the system of “5G + AI+Education” from the perspective of, on the one hand, the real need for the problems that gradually emerge in the new round of development and application of artificial intelligence, and a philosophical reflection on the application of artificial intelligence in specific fields, on the other hand. It is also a further examination of the issue of human subjectivity in the new context. On the other hand, it is also a further examination of the issue of human subjectivity in the new context of the times, which can also provide students with an immersive learning environment, and AI artificial intelligence and hologram technology can enhance students’ motivation. This paper shows the specific steps and implementation measures of “5G” technology into online oral teaching and provides a case study design to explore the new online oral teaching model, summarizing the advantages and proposing solutions to the shortcomings. The system visualizes each step of gesture recognition to facilitate students’ understanding. Students can experience the process of gesture recognition according to the guidance of the interactive interface, and then, the complex and abstract gesture recognition process is explained with a figurative example, which is conducive to primary and secondary school students’ deeper understanding and improved logical thinking. This will help primary and secondary school students to have a deeper understanding and improve their logical thinking skills. Finally, a comparison experiment is designed to verify the effectiveness of using this system to learn AI knowledge compared with traditional learning methods. The experimental results are analyzed to prove that using this system to learn AI knowledge is effective and helps improve users’ interest in learning and hands‐on ability.
Research on Intelligent Calibration of English Long Sentence Translation Based on Corpus
Authors: Qiu Haimei
Published: September 2021

With the continuous promotion and development of the new curriculum reform, English teaching is becoming more practical and comprehensive. As an indispensable part of daily English topics, the use rate and scope of English attributive clauses are extensive. Moreover, due to English attributive provisions, the length of the whole English sentence will inevitably increase; therefore, we can accurately understand and translate sentences by mastering the translation and understanding details of attributive clauses. In addition, there are noticeable differences between English and Chinese in attributive clauses. Chinese will not add a variety of modifiers like English but will directly put them in front of them as attributives, so we should pay attention to this in translation. This process increases the difficulty of the English translation. Therefore, this paper proposes a Corpus-based intelligent calibration of English long sentence translation. Based on the construction of the English long sentence Corpus, an intelligent calibration algorithm for English long sentence translation is designed, and experiments verify the effectiveness of this method.
The Effect of Renalase rs2576178 and rs10887800 Polymorphisms on Ischemic Stroke Susceptibility in Young Patients (<50 Years): A Case-Control Study and In Silico Analysis
Authors: Ramroodi Nourollah , Khorrami Azar , Hashemi Seyed Mehdi , Rezaei Mahnaz , Shahraki-ghadim Hossein , Salimi Saeedeh
Published: September 2021

Background. Ischemic stroke (IS) is the most common form of cerebrovascular accident which its precise etiology remains mysterious. Renalase is a catecholamine-degrading enzyme playing a major role in blood pressure control. Recent studies show the effect of renalase activity on various diseases like IS. In the current study, we examined the possible effects of renalase gene (RNLS) rs2576178 and rs10887800 variants at the 5

′

-flanking and intron 6 regions on IS, respectively. Methods. One hundred and fifty-four IS patients younger than 50 years and 165 age- and sex-matched controls were recruited in the study. For genotyping of rs2576178 and rs10887800 variants, the PCR-RFLP method was used. Results. The RNLS rs10887800 AG genotype was more repeated in IS patients, but the difference was marginally nonsignificant (

P
=
0.054

). This variant was associated with IS in the overdominant model, and the AG genotype is associated with a1.6-fold increased risk of IS compared to AA+ GG genotypes (

OR
=
1.6

, 95% CI: 1-2.5,

P
=
0.033

). No relationship was observed between RNLS rs2576178 polymorphism and IS in all genetic models. The findings of the haplotype and combination effects of rs10887800 and rs2576178 variants on IS showed no significant association. The in silico analysis showed no effect of rs2576178 and rs10887800 polymorphisms in the RNA structure, but the alteration of RNA sequence in rs2576178 results in the lack of a MBNL1 protein binding site. Conclusions. RNLS rs10887800 but not rs2576178 polymorphism was associated with IS susceptibility in the overdominant model (AG vs AA+ GG genotypes).
An Unusual Location for a Nonurachal Bladder Adenocarcinoma
Authors: Khludenev George , Reddy Akshay , Akosman Sinan , Whalen Michael J.
Published: September 2021

Malignant bladder neoplasms represent a significant disease burden not only for urologists but also the broader medical community. While the majority of bladder tumors are urothelial in origin, up to two percent are found to be adenocarcinomas. Among bladder adenocarcinomas, roughly one-tenth are urachal and are frequently located at the dome of the bladder where urachal remnants can often be found. We describe a case of bladder adenocarcinoma that presented at the dome of the bladder but ultimately exhibited a nonurachal histology. A 65-year-old male with a history of myocardial infarction and cerebrovascular accident with residual right-sided hemiparesis and aphasia was referred to our clinic for evaluation of a bladder mass discovered in the setting of painless gross hematuria. Diagnostic cystoscopy demonstrated a large mass at the dome of the bladder, and subsequent transurethral resection revealed stage T1 mucinous adenocarcinoma arising in a villous adenomatous lesion without the presence of muscle in the specimen. The patient underwent a robotic-assisted laparoscopic partial cystectomy with extended bilateral pelvic lymph node dissection. Postoperatively, the patient experienced short-lived paralytic ileus and was discharged on postoperative day 5. Follow-up surveillance imaging at 6 months with CT chest, abdomen, and pelvis, repeat office cystoscopy, and negative tumor markers postoperatively indicated no evidence of disease recurrence. Characterization of bladder adenocarcinomas into urachal and nonurachal subtypes is critical in differentiating the operative management and oncologic outcomes of the respective neoplasms. However, given the paucity of literature describing treatment approaches to bladder adenocarcinoma in general, existing methods have largely mirrored genetically similar neoplasms, including ovarian and colon adenocarcinomas. Although there is still much to be understood regarding the potential mechanisms of carcinogenesis of nonurachal adenocarcinomas, further investigation may pave the way for a more standardized treatment paradigm and provide insight into the potential utility of modern immunotherapies.
Macrophages M1-Related Prognostic Signature in Hepatocellular Carcinoma
Authors: Zhang Hao , Sun Lin , Hu Xiao
Published: September 2021

A large number of studies have found that macrophages M1 play an important role in the occurrence and development of tumors. The aim of our study is to explore the causes of differential infiltration of macrophages M1 in hepatocellular carcinoma from the perspective of transcriptome and establish a prognostic model of hepatocellular carcinoma. We downloaded gene expression and clinical data from the public database, estimated the content of macrophages M1 in different samples with R software, and found the different genes between high- and low-infiltration groups. Using differentially expressed genes, we constructed a model composed of 7 genes. The risk score of the model has a good ability to predict the prognosis, has a positive correlation with immune checkpoints, and is closely related to other immune cells and immune function. Our model shows good prognostic function and has wide application value.
Prevalence of Self-Reported Work-Related Lower Back Pain and Its Associated Factors in Ethiopia: A Systematic Review and Meta-Analysis
Authors: Jegnie Mihretu , Afework Mekbeb
Published: September 2021

Introduction. Low back pain is the commonest musculoskeletal disorder affecting every socioeconomic group of the world’s population. The lifetime risk of developing low back pain is about 60%–80%. The pooled prevalence and associated factors of low back pain have not yet been determined in Ethiopia. Thus, this study was aimed at assessing the overall prevalence of low back pain and its associated factors in Ethiopia. Methods. A systematic search of PubMed, Scopus, Science Direct, and Google Scholar for observational studies reporting data on the prevalence and associated factors of low back pain was conducted. Relevant data were extracted with a standardized data extraction excel form. Stata 14 was employed for the meta-analysis. Heterogeneity was assessed by Cochran’s Q test and I2 values of a forest plot. Publication bias was checked using a funnel plot and Egger’s test. A random-effects model was used in the analysis. Result. A total of thirty-two studies were included for the systematic review. Twenty-four and sixteen studies were used to pool the overall low back pain prevalence and associated factors, respectively. The overall pooled annual prevalence of low back pain in Ethiopia was estimated to be 54.05% (95% CI: 48.14–59.96). Age, sex, body mass index, work experience, working hours, lack of safety training, awkward working posture, work shift, prolonged standing, lifting heavy objects, sleeping disturbance, history of back trauma, previous medical history of musculoskeletal disorder, and lack of adequate rest interval at work were significantly associated with low back pain. Conclusion. The current systematic review and meta-analysis revealed a higher prevalence of lower back pain in Ethiopia. Most of the low back pain epidemiological studies conducted in Ethiopia focused on specific occupational settings, making pooling of data and comparison with other countries challenging. Thus, further general population studies are recommended.
Experimental Study on Enhanced Oil Recovery by Nitrogen-Water Alternative Injection in Reservoir with Natural Fractures
Authors: Li Xiang , Cheng Yuan , Tao Wulong , Sarulicaoketi Shalake , Ji Xuhui , Yin Changhe
Published: September 2021

The production of a low permeability reservoir decreases rapidly by depletion development, and it needs to supplement formation energy to obtain stable production. Common energy supplement methods include water injection and gas injection. Nitrogen injection is an economic and effective development method for specific reservoir types. In order to study the feasibility and reasonable injection parameters of nitrogen injection development of fractured reservoir, this paper uses long cores to carry out displacement experiment. Firstly, the effects of water injection and nitrogen injection development of a fractured reservoir are compared through experiments to demonstrate the feasibility of nitrogen injection development of the fractured reservoir. Secondly, the effects of gas-water alternate displacement after water drive and gas-water alternate displacement after gas drive are compared through experiments to study the situation of water injection or gas injection development. Finally, the reasonable parameters of nitrogen gas-water alternate injection are optimized by orthogonal experimental design. Results show that nitrogen injection can effectively enhance oil production of the reservoir with natural fractures in early periods, but gas channeling easily occurs in continuous nitrogen flooding. After water flooding, gas-water alternate flooding can effectively reduce the injection pressure and improve the reservoir recovery, but the time of gas-water alternate injection cannot be too late. It is revealed that the factors influencing the nitrogen-water alternative effect are sorted from large to small as follows: cycle injected volume, nitrogen and water slug ratio, and injection rate. The optimal cycle injected volume is around 1 PV, the nitrogen and water slug ratio is between 1 and 2, and the injection rate is between 0.1 and 0.2 mL/min.
Ginsenoside Rh2 Suppresses Metastasis and Growth of Colon Cancer via miR-491
Authors: Wei Wene , Guo Qijing , Guo Cuiping , Cui Xianshu , Ma Xuemei , Shen Xianliang , Luo Yushuang
Published: September 2021

Ginsenoside Rh2 is considered as a new direction for future cancer treatment because of its excellent anticancer effect. However, due to its low bioavailability, it cannot exert its significant anticancer effect when applied directly to the human body. Chitosan (CS), a nanomaterial, has been verified to be able to enhance drug efficacy via its coating for drugs. Thus, we designed this study to investigate the impact of CS-coated ginsenoside Rh2 on the metastasis and growth of colon cancer (CC). First, ginsenoside Rh2 chitosan tripolyphosphate (CS-Rh2-TPP) nanoparticles (NPs) were constructed, and MTT, transwell, scratch adhesion, and flow cytometry assays were carried out for determining the impact of CS-Rh2-TPP at various concentrations on growth, metastasis, and apoptosis of colon cancer cells (CCCs). qRT-PCR was used to detect the expression of mircoRNA-491 (miR-491) in CCCs. According to TEM-based image analysis, CS-Rh2-TPP NPs were spherical or spheroidal in even distribution, with a particle size of about 220 mm and a zeta potential of −44.58 ± 2.84 mV. Additionally, CCCs presented lower miR-491 than normal colon cells, and its relative expression in CCCs showed a stronger increase after intervention of CS-Rh2-TPP than that after intervention of ginsenoside Rh2. Moreover, CS-Rh2-TPP suppressed the activity, invasion, as well as migration of CCCs and accelerated their apoptosis more significantly than ginsenoside Rh2. According to these results, CS-Rh2-TPP is able to upregulate miR-491 in CCCs, thus suppressing the metastasis and growth of CC.
Construction of Mental Health Education Model Based on Computer Multimedia Group Psychological Measurement
Authors: Zhang Haiyan
Published: September 2021

Modern people's concept of health is more comprehensive; in addition to physical health, they focus on mental health even more. Computer multimedia group psychological measurement is introduced, and a mental health education model is constructed in this paper. The model includes three interrelated levels: mechanism level, evaluation level, and target level. It emphasizes the key and core role of mental quality in mental health. It advocates incorporating mental quality into the evaluation and diagnosis system of the overall state of individual mental health, combines the classified qualitative assessment and quantitative assessment, and arranges appropriate prevention and intervention measures according to different types of individuals. Practice has proved that this method is effective.
A Novel Use of Laryngoscope for Difficult Papanicolaou Smear Collection
Authors: Boudova Sarah , Thomas Caitlin , Wolfe John , Schilder Jeanne M.
Published: September 2021

The prevalence of cervical cancer has dropped significantly since introduction of the Papanicolaou (Pap) screen. The greatest risk factor for cervical cancer is inadequate screening. Altered pelvic anatomy can limit the ability to collect a Pap smear. In the presented case, a woman with a history of fibroids and bleeding presented for an exam under anesthesia. Traditional approaches for collecting a Pap smear failed. A GlideScope video laryngoscope was used to visualize the cervix, and a Pap smear was collected. The specimen was satisfactory, negative for intraepithelial lesion or malignancy, and HPV negative. A laryngoscope can be repurposed to visualize collection of a challenging Pap smear. Novel approaches for Pap smear collection and cervical cancer screening are needed and have the potential to save lives.
Long Term Outcome and Histologic Findings of a Retinal Astrocytic Hamartoma Treated with Intravitreal Injection of Anti-VEGF: A Case Report
Authors: Ahmad Kinza T. , Mansour Hana A. , Rollins Benjamin T. , Oviedo Sergio Pina , Phillips Paul H. , Uwaydat Sami H.
Published: September 2021

Background. To our knowledge, this is the first report to describe the histologic changes of a retinal astrocytic hamartoma (RAH) in a patient with tuberous sclerosis complex (TSC) treated with antivascular endothelial growth factor (anti-VEGF), as well as the longest anti-VEGF treatment that such a patient has received (3 years). Case Presentation. We present a case of a 20-year-old female with TSC who developed progressive growth of a papillary astrocytic hamartoma that caused significant retinal edema, vitreous hemorrhage, and neovascular glaucoma. The patient was initially treated with 25 intravitreal anti-VEGF injections about every 1-3 months, but eventually developed a blind painful eye from neovascular glaucoma. Histopathologic evaluation of the enucleated globe showed a peculiar difference of the tumor according to its topography, with features reminiscent of pilocytic astrocytoma at the optic nerve head and features reminiscent of subependymal giant cell astrocytoma at the retrolaminar optic nerve. We hypothesize that these changes occurred as a secondary effect of the anti-VEGF treatment. Conclusions. Anti-VEGF agents may decrease the ophthalmologic complications of RAH. We recommend that this treatment should be started early and continued for a protracted time at regular and frequent intervals. Moreover, a combination of therapies might prove to be superior to monotherapy and should therefore be considered in aggressive retinal astrocytic hamartomas.
Fabrication of a Lead Head Made of the Carbon-Fiber-Reinforced Composite for the Temporary Cardiac Pacemaker
Authors: Zhou Yucheng , Lin Xuming , Yang Zhao , Han Xiaotong , Liu Meng
Published: September 2021

Compared with traditional leads, carbon fiber composite leads have a series of advantages such as lightweight, soft texture, and high conductivity. In this experiment, we attempted to improve the existing carbon-fiber-based TTCP metal leads by using carbon-fiber-graphene-woven leads or conductive cloth, so as to solve a series of defects of TTCP metal leads commonly used in the clinical temporary cardiac pacemaker. We performed a series of measurements, including resistance comparisons and stability checks on the finished product characteristics. The results showed that the resistivity of the whole lead did not change significantly after modification, and the carbon fiber bundle was stable and easily deformed under lower stress to reduce the damage to the myocardium, which had excellent clinical application value.