bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-Wide Organization and Expression Profiling of the SBP-Box Gene Family in Chinese Jujube (Ziziphus jujuba Mill.)
Authors: Song Shuang , Zhou Heying , Sheng Songbai , Cao Ming , Li Yingyue , Pang Xiaoming
Published: August 2017

Transcription factors play vital roles in the developmental processes of plants. The SQUAMOSA promoter binding protein (SBP) genes encode a family of plant-specific transcription factors and plays many crucial roles in plant development. In this study, 16 SBP-box gene family members were identified in Ziziphus jujuba Mill. Dongzao (Dongzao), which were distributed over 8 chromosomes. They were classified into seven groups according to their phylogenetic relationships with other SBP-box gene families. Within each group, genes shared similar exon-intron structures and motif locations. The number of exons varied among the groups. We identified 12 homologous gene pairs between Dongzao and Arabidopsis. Expression profiling revealed that ZjSBP02 and ZjSBP14 expressed highly in mature fruits, ZjSBP01 expressed higher in mature leaves than other tissues and the expression level of ZjSBP12 was much higher in the flowers. The transcriptome analysis indicated that ZjSBPs had different expression patterns in various tissues. This study represents the first systematic analysis of the SBP-box gene family in Z. jujuba. The data presented here provides a foundation for understanding the crucial roles of ZjSBP genes in plant growth and development.
Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus
Authors: Tarasen Ashley , Carlson J. , Leonard M. , Merlino Glenn , Kaetzel David , Slominski Andrzej
Published: August 2017

Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type melanoma. Histologically PEMs are heavily pigmented spindled and epithelioid dermal melanocytic tumors with infiltrative borders, however, their origin remains unclear. Stem cells for the epidermis and hair follicle are located in the bulge area of the hair follicle with the potential to differentiate into multiple lineages. Multiple cutaneous carcinomas, including follicular cutaneous squamous cell carcinoma (FSCC), are thought to arise from stem cells in the follicular bulge. We present two cases of PEM/ATM in a 63 year-old male on the scalp with follicular origin and a 72 year-old female on the upper back arising in an intradermal nevus. Biopsy of both cases revealed a proliferation of heavily pigmented dermal nests of melanocytes with atypia. The Case 1 tumor was in continuation with the outer root sheath of the hair follicle in the bulge region. Case 2 arose in an intradermal melanocytic nevus. Rare mitotic figures, including atypical mitotic figures, were identified in both cases. We present two cases of PEM, with histologic evidence suggesting two origins: one from the follicular bulb and one from an intradermal nevus.
Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development
Authors: Escoté Xavier , Gómez-Zorita Saioa , López-Yoldi Miguel , Milton-Laskibar Iñaki , Fernández-Quintela Alfredo , Martínez J. , Moreno-Aliaga María , Portillo María
Published: August 2017

Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and adipose tissue secretion in adults and adolescents. This adipokine regulates insulin sensitivity, but its clinical relevance has to be confirmed. Vaspin is produced by visceral and subcutaneous adipose tissues. Vaspin levels are higher in obese subjects, as well as in subjects showing insulin resistance or type 2 diabetes. Cardiotrophin-1 is an adipokine with a similar structure as cytokines from interleukin-6 family. There is some controversy regarding the regulation of cardiotrophin-1 levels in obese -subjects, but gene expression levels of cardiotrophin-1 are down-regulated in white adipose tissue from diet-induced obese mice. It also shows anti-obesity and hypoglycemic properties. TWEAK is a potential regulator of the low-grade chronic inflammation characteristic of obesity. TWEAK levels seem not to be directly related to adiposity, and metabolic factors play a critical role in its regulation. Finally, a strong correlation has been found between plasma NOV/CCN3 concentration and fat mass. This adipokine improves insulin actions.
Anti-Collision Assessment and Prediction Considering Material Corrosion on an Offshore Protective Device
Authors: Qiu Ang , Han Xiangxi , Qin Hongyu , Lin Wei , Tang Youhong
Published: August 2017

Corrosion deterioration of steel can heavily degrade the performance of marine and offshore structures. A typical steel protective device, which has worked for a dozen years in a river estuary, is selected as the research object. Its current corrosion response is measured on site and its further corrosive response is predicted based on measurement data and the structure’s current state. Nonlinear finite element method is utilized to analyze the degradation of the protective device’s anti-collision performance. Meanwhile the rubber buffer effect has been investigated for its anti-collision on the protective device. A prediction method is proposed that can accurately forecast degradation of the anti-collision performance of a protective device as time progresses.
RedEdge: A Novel Architecture for Big Data Processing in Mobile Edge Computing Environments
Authors: Habib ur Rehman Muhammad , Jayaraman Prem , Malik Saif , Khan Atta , Medhat Gaber Mohamed
Published: August 2017

We are witnessing the emergence of new big data processing architectures due to the convergence of the Internet of Things (IoTs), edge computing and cloud computing. Existing big data processing architectures are underpinned by the transfer of raw data streams to the cloud computing environment for processing and analysis. This operation is expensive and fails to meet the real-time processing needs of IoT applications. In this article, we present and evaluate a novel big data processing architecture named RedEdge (i.e., data reduction on the edge) that incorporates mechanism to facilitate the processing of big data streams near the source of the data. The RedEdge model leverages mobile IoT-termed mobile edge devices as primary data processing platforms. However, in the case of the unavailability of computational and battery power resources, it offloads data streams in nearer mobile edge devices or to the cloud. We evaluate the RedEdge architecture and the related mechanism within a real-world experiment setting involving 12 mobile users. The experimental evaluation reveals that the RedEdge model has the capability to reduce big data stream by up to 92.86% without compromising energy and memory consumption on mobile edge devices.
Update on Monoterpenes as Antimicrobial Agents: A Particular Focus on p-Cymene
Authors: Marchese Anna , Arciola Carla , Barbieri Ramona , Silva Ana , Nabavi Seyed , Tsetegho Sokeng Arold , Izadi Morteza , Jafari Nematollah , Suntar Ipek , Daglia Maria , Nabavi Seyed
Published: August 2017

p-Cymene [1-methyl-4-(1-methylethyl)-benzene] is a monoterpene found in over 100 plant species used for medicine and food purposes. It shows a range of biological activity including antioxidant, anti-inflammatory, antinociceptive, anxiolytic, anticancer and antimicrobial effects. This last property has been widely investigated due to the urgent need for new substances with antimicrobial properties, to be used to treat communicable diseases whose diffusion in developed countries has been facilitated by globalization and the evolution of antimicrobial resistance. This review summarizes available scientific data, as reported by the most recent studies describing the antimicrobial activity of p-cymene either alone, or as the main component of plant extracts, as well as addressing the mechanisms of action of cymenes as antimicrobial agents. While p-cymene is one of the major constituents of extracts and essential oils used in traditional medicines as antimicrobial agents, but considering the limited data on its in vivo efficacy and safety, further studies are required to reach a definitive recommendation on the use and beneficial effects of p-cymene in human healthcare and in biomedical applications as a promising candidate to functionalize biomaterials and nanomaterials.
An Algorithm for Surface Defect Identification of Steel Plates Based on Genetic Algorithm and Extreme Learning Machine
Authors: Tian Siyang , Xu Ke
Published: August 2017

Defects on the surface of steel plates are one of the most important factors affecting the quality of steel plates. It is of great importance to detect such defects through online surface inspection systems, whose ability of defect identification comes from self-learning through training samples. Extreme Learning Machine (ELM) is a fast machine learning algorithm with a high accuracy of identification. ELM is implemented by a hidden matrix generated with random initialization parameters, while different parameters usually result in different performances. To solve this problem, an improved ELM algorithm combined with a Genetic Algorithm was proposed and applied for the surface defect identification of hot rolled steel plates. The output matrix of the ELM’s hidden layers was treated as a chromosome, and some novel iteration rules were added. The algorithm was tested with 1675 samples of hot rolled steel plates, including pockmarks, chaps, scars, longitudinal cracks, longitudinal scratches, scales, transverse cracks, transverse scratches, and roll marks. The results showed that the highest identification accuracies for the training and the testing set obtained by the G-ELM (Genetic Extreme Learning Machine) algorithm were 98.46% and 94.30%, respectively, which were about 5% higher than those obtained by the ELM algorithm.
Micromachining on and of Transparent Polymers for Patterning Electrodes and Growing Electrically Active Cells for Biosensor Applications
Authors: Karnati Chandana , Aguilar Ricardo , Arrowood Colin , Ross James , Rajaraman Swaminathan
Published: August 2017

We report on microfabrication and assembly process development on transparent, biocompatible polymers for patterning electrodes and growing electrically active cells for in vitro cell-based biosensor applications. Such biosensors are typically fabricated on silicon or glass wafers with traditional microelectronic processes that can be cost-prohibitive without imparting necessary biological traits on the devices, such as transparency and compatibility for the measurement of electrical activity of electrogenic cells and other biological functions. We have developed and optimized several methods that utilize traditional micromachining and non-traditional approaches such as printed circuit board (PCB) processing for fabrication of electrodes and growing cells on the transparent polymers polyethylene naphthalate (PEN) and polyethylene terephthalate (PET). PEN-based biosensors are fabricated utilizing lithography, metal lift-off, electroplating, wire bonding, inkjet printing, conformal polymer deposition and laser micromachining, while PET-based biosensors are fabricated utilizing post-processing technologies on modified PCBs. The PEN-based biosensors demonstrate 85–100% yield of microelectrodes, and 1-kHz impedance of 59.6 kOhms in a manner comparable to other traditional approaches, with excellent biofunctionality established with an ATP assay. Additional process characterization of the microelectrodes depicts expected metal integrity and trace widths and thicknesses. PET-based biosensors are optimized for a membrane bow of 6.9 to 15.75 µm and 92% electrode yield on a large area. Additional qualitative optical assay for biomaterial recognition with transmitted light microscopy and growth of rat cortical cells for 7 days in vitro (DIV) targeted at biological functionalities such as electrophysiology measurements are demonstrated in this paper.
Effect of 2,6-Bis-(1-hydroxy-1,1-diphenyl-methyl) Pyridine as Organic Additive in Sulfide NiMoP/γ-Al2O3 Catalyst for Hydrodesulfurization of Straight-Run Gas Oil
Authors: Santolalla-Vargas Carlos , Santes Victor , Meneses-Domínguez Erick , Escamilla Vicente , Hernández-Gordillo Agileo , Gómez Elizabeth , Sánchez-Minero Felipe , Escobar José , Díaz Leonardo , Goiz Oscar
Published: August 2017

The effect of 2,6-bis-(1-hydroxy-1,1-diphenyl-methyl) pyridine (BDPHP) in the preparation of NiMoP/γ-Al2O3 catalysts have been investigated in the hydrodesulfurization (HDS) of straight-run gas oil. The γ-Al2O3 support was modified by surface impregnation of a solution of BDPHP to afford BDPHP/Ni molar ratios (0.5 and 1.0) in the final composition. The highest activity for NiMoP materials was found when the molar ratio of BDPHP/Ni was of 0.5. X-ray diffraction (XRD) results revealed that NiMoP (0.5) showed better dispersion of MoO3 than the NiMoP (1.0). Fourier transform infrared spectroscopy (FT-IR) results indicated that the organic additive interacts with the γ-Al2O3 surface and therefore discards the presence of Mo or Ni complexes. Raman spectroscopy suggested a high Raman ratio for the NiMoP (0.5) sample. The increment of the Mo=O species is related to a major availability of Mo species in the formation of MoS2. The temperature programmed reduction (TPR) results showed that the NiMoP (0.5) displayed moderate metal–support interaction. Likewise, X-ray photoelectron spectroscopy (XPS) exhibited higher sulfurization degree for NiMoP (0.5) compared with NiMoP (1.0). The increment of the MoO3 dispersion, the moderate metal–support interaction, the increase of sulfurization degree and the increment of Mo=O species provoked by the BDPHP incorporation resulted in a higher gas oil HDS activity.
Fenton Discoloration of Ultrasonicated Purple Cactus Pear Juice
Authors: Reyes-Hernández Isidro , Cruz-Cansino Nelly , Santander-Martínez Ingrid , Alanís-García Ernesto , Delgado-Olivares Luis , Ramírez-Moreno Esther , Ariza-Ortega José , Omaña-Covarrubias Ariana , Torres-Valencia Jesús , Manríquez-Torres José
Published: August 2017

The aim of this study was to evaluate the stability of color, betaxanthin, and betacyanin pigments in the presence of Cu(II)-dependent hydroxyl radicals (HO•) from ultrasonicated purple cactus pear juice at amplitudes of 40%, 60%, and 80%, in comparison to untreated sample. L* parameter of juice treated at 40% and 80% amplitude for 25 and 15 min, respectively (11.3 and 9.3, respectively), were significantly higher compared to the control; b* and hue parameters of juice treated at 80%, 25 min showed values of 1.7 and 0.1, respectively. Color differences (ΔE) were lower (<3) for juices treated at high amplitude (80%) and short times (3–5 min). Juice treated at 40% 15 min, 60% 25 min, 80% 15 and 25 min presented high values of betacyanins (281.7 mg·L−1, 255.9 mg·L−1, 294.4 mg·L−1, and 276.7 mg·L−1, respectively). Betaxanthin values were higher in the juices treated at 40% 5 min and 80% 15 and 25 min (154.2 mg·L−1, 135.2 mg·L−1, and 128.5 mg·L−1, respectively). Purple cactus pear juice exhibited significant chelating activity of copper ions and great stability when exposed to HO•.
Synthesis and Physicochemical Characterization of the Process-Related Impurities of Eplerenone, an Antihypertensive Drug
Authors: Dams Iwona , Białońska Agata , Cmoch Piotr , Krupa Małgorzata , Pietraszek Anita , Ostaszewska Anna , Chodyński Michał
Published: August 2017

Two unknown impurities were observed during the process development for multigram-scale synthesis of eplerenone (Inspra®). The new process-related impurities were identified and fully characterized as the corresponding (7β,11α,17α)-11-hydroxy- and (7α,11β,17α)-9,11-dichloroeplerenone derivatives 12a and 13. Seven other known but poorly described in the literature eplerenone impurities, including four impurities A, B, C and E listed in the European Pharmacopoeia 8.4 were also detected, identified and fully characterized. All these contaminants result from side reactions taking place on the steroid ring C of the starting 11α-hydroxy-7α-(methoxycarbonyl)-3-oxo-17α-pregn-4-ene-21,17-carbolactone (12) and the key intermediate (7α,17α)-9(11)-enester 7, including epimerization of the C-7 asymmetric center, oxidation, dehydration, chlorination and lactonization. The impurities were isolated and/or synthesized and fully characterized by infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR) and high-resolution mass spectrometry/electrospray ionization (HRMS/ESI). Their 1H- and 13C-NMR signals were fully assigned. The molecular structures of the eight impurities, including the new (7β,11α,17α)-11-hydroxy- and (7α,11β,17α)-9,11-dichloroeplerenone related substances 12a and 13, were solved and refined using single-crystal X-ray diffraction (SCXRD). The full identification and characterization of these impurities should be useful for the quality control and the validation of the analytical methods in the manufacture of eplerenone.
Comparison of the Effects of Goat Dairy and Cow Dairy Based Breakfasts on Satiety, Appetite Hormones, and Metabolic Profile
Authors: Rubio-Martín Elehazara , García-Escobar Eva , Ruiz de Adana Maria-Soledad , Lima-Rubio Fuensanta , Peláez Laura , Caracuel Angel-María , Bermúdez-Silva Francisco-Javier , Soriguer Federico , Rojo-Martínez Gemma , Olveira Gabriel
Published: August 2017

The satiating effects of cow dairy have been thoroughly investigated; however, the effects of goat dairy on appetite have not been reported so far. Our study investigates the satiating effect of two breakfasts based on goat or cow dairy and their association with appetite related hormones and metabolic profile. Healthy adults consumed two breakfasts based on goat (G-Breakfast) or cow (C-Breakfast) dairy products. Blood samples were taken and VAS tests were performed at different time points. Blood metabolites were measured and Combined Satiety Index (CSI) and areas under the curves (AUC) were calculated. Desire to eat rating was significantly lower (breakfast & time interaction p < 0.01) and hunger rating tended to be lower (breakfast & time interaction p = 0.06) after the G-breakfast. None of the blood parameters studied were different between breakfasts; however, AUCGLP-1 was inversely associated with the AUChunger and AUCdesire-to-eat after the G-Breakfast, whereas triglyceride levels were directly associated with AUCCSI after the C-Breakfast. Our results suggest a slightly higher satiating effect of goat dairy when compared to cow dairy products, and pointed to a potential association of GLP-1 and triglyceride levels with the mechanisms by which dairy products might affect satiety after the G-Breakfast and C-Breakfast, respectively.
Fat Sensation: Fatty Acid Taste and Olfaction Sensitivity and the Link with Disinhibited Eating Behaviour
Authors: Kindleysides Sophie , Beck Kathryn , Walsh Daniel , Henderson Lisa , Jayasinghe Shakeela , Golding Matt , Breier Bernhard
Published: August 2017

Perception of fat taste, aroma, and texture are proposed to influence food preferences, thus shaping dietary intake and eating behaviour and consequently long-term health. In this study, we investigated associations between fatty acid taste, olfaction, mouthfeel of fat, dietary intake, eating behaviour, and body mass index (BMI). Fifty women attended three sessions to assess oleic acid taste and olfaction thresholds, the olfactory threshold for n-butanol and subjective mouthfeel ratings of custard samples. Dietary intake and eating behaviour were evaluated using a Food Frequency and Three-Factor Eating Questionnaire, respectively. Binomial regression analysis was used to model fat taste and olfaction data. Taste and olfactory detection for oleic acid were positively correlated (r = 0.325; p < 0.02). Oleic acid taste hypersensitive women had significantly increased n-butanol olfactory sensitivity (p < 0.03). The eating behaviour disinhibition and BMI were higher in women who were hyposensitive to oleic acid taste (p < 0.05). Dietary intake of nuts, nut spreads, and seeds were significantly correlated with high olfactory sensitivity to oleic acid (p < 0.01). These findings demonstrate a clear link between fatty acid taste sensitivity and olfaction and suggest that fat taste perception is associated with specific characteristics of eating behaviour and body composition.
Diet Quality Scores of Australian Adults Who Have Completed the Healthy Eating Quiz
Authors: Williams Rebecca , Rollo Megan , Schumacher Tracy , Collins Clare
Published: August 2017

Higher scores obtained using diet quality and variety indices are indicators of more optimal food and nutrient intakes and lower chronic disease risk. The aim of this paper is to describe the overall diet quality and variety in a sample of Australian adults who completed an online diet quality self-assessment tool, the Healthy Eating Quiz. The Healthy Eating Quiz takes approximately five minutes to complete online and computes user responses into a total diet quality score (out of a maximum of 73 points) and then categorizes them into the following groups: ‘needs work’ (<33), ‘getting there’ (33–38), ‘excellent’ (39–46), or ’outstanding’ (47+). There was a total of 93,252 first-time respondents, of which 76% were female. Over 80% of respondents were between 16–44 years of age. The mean total score was 34.1 ± 9.7 points. Females had a higher total score than males (p < 0.001) and vegetarians had higher total scores than non-vegetarians (p < 0.001). Healthy eating quiz scores were higher in those aged 45–75 years compared to 16–44 years (p < 0.001). When comparing Socioeconomic Indices for Areas deciles, those most disadvantaged had a lower total score than those least disadvantaged (p < 0.001). Repeat measures showed that those who scored lowest (needs work) in their first completion increased their total score by 3.2 ± 7.4 at their second completion (p < 0.001). While the Healthy Eating Quiz data indicates that individuals receiving feedback on how to improve their score can improve their diet quality, there is a need for further nutrition promotion interventions in Australian adults.
Folate Receptor-Positive Gynecological Cancer Cells: In Vitro and In Vivo Characterization
Authors: Siwowska Klaudia , Schmid Raffaella , Cohrs Susan , Schibli Roger , Müller Cristina
Published: August 2017

The folate receptor (FR) is expressed in a variety of gynecological cancer types. It has been widely used for tumor targeting with folic acid conjugates of diagnostic and therapeutic probes. The cervical KB tumor cells have evolved as the standard model for preclinical investigations of folate-based (radio) conjugates. In this study, a panel of FR-expressing human cancer cell lines—including cervical (HeLa, KB, KB-V1), ovarian (IGROV-1, SKOV-3, SKOV-3.ip), choriocarcinoma (JAR, BeWo) and endometrial (EFE-184) tumor cells—was investigated in vitro and for their ability to grow as xenografts in mice. FR-expression levels were compared in vitro and in vivo and the cell lines were characterized by determination of the sensitivity towards commonly-used chemotherapeutics and the expression of two additional, relevant tumor markers, HER2 and L1-CAM. It was found that, besides KB cells, its multiresistant KB-V1 subclone as well as the ovarian cancer cell lines, IGROV-1 and SKOV-3.ip, could be used as potentially more relevant preclinical models. They would allow addressing specific questions such as the therapeutic efficacy of FR-targeting agents in tumor (mouse) models of multi-resistance and in mouse models of metastases formation.
Aromatic Modification of Low Molecular Weight PEI for Enhanced Gene Delivery
Authors: Yu Qing-Ying , Zhan Yu-Rong , Zhang Ji , Luan Chao-Ran , Wang Bing , Yu Xiao-Qi
Published: August 2017

Low molecular weight polyethylenimine (1800 Da, also referred to as oligoethylenimines, OEI) was modified with amino acids, including two aromatic amino acids (tryptophan, phenylalanine) and an aliphatic amino acid (leucine). The substitution degree of amino acids could be controlled by adjusting the feeding mole ratio of the reactants. Fluorescence spectroscopy and circular dichroism experiments demonstrated that the indole ring of tryptophan may intercalate into the DNA base pairs and contribute to efficient DNA condensation. In vitro gene expression results revealed that the modified OEIs (OEI-AAs) may provide higher transfection efficiency even than high molecular weight polyethylenimine (25 kDa, PEI), especially the aromatic tryptophan substituted OEI. Moreover, OEI-AAs exhibited excellent serum tolerance, and up to 137 times higher transfection efficiency than PEI 25 kDa that was obtained in the presence of serum. The cytotoxicity of OEI-AAs is much lower than PEI 25 kDa. This study may afford a new method for the development of low molecular weight oligomeric non-viral gene vectors with both high efficiency and biocompatibility.
Auguste Comte and Consensus Formation in American Religious Thought—Part 2: Twilight of New England Comtism
Authors: Sacks Kenneth
Published: August 2017

Auguste Comte was the most influential sociologist and philosopher of science in the Nineteenth Century. Part 1 summarized his works and analyzed reactions to them by Transcendentalists and Unitarians from 1837 until just after the Civil War. Part 2 examines in detail the post-war Transcendentalist and liberal Unitarian institutions of the Free Religious Association and the Radical Club and their different approaches to spiritual faith based on intuitionalism and reliance on scientific proof. In the background to their disputes is the positivism of Auguste Comte, who served as an easy source of common criticism. But at the same time as they wrote against positivism, both intuitionalists and those who relied on science were significantly influenced by Comte. Once again, as in part 1, a community of discourse was formed through the need to create social bonds at the expense of careful evaluation of the philosophy they criticized.
Octopus: A Design Methodology for Motion Capture Wearables
Authors: Marin Javier , Blanco Teresa , Marin Jose
Published: August 2017

Human motion capture (MoCap) is widely recognised for its usefulness and application in different fields, such as health, sports, and leisure; therefore, its inclusion in current wearables (MoCap-wearables) is increasing, and it may be very useful in a context of intelligent objects interconnected with each other and to the cloud in the Internet of Things (IoT). However, capturing human movement adequately requires addressing difficult-to-satisfy requirements, which means that the applications that are possible with this technology are held back by a series of accessibility barriers, some technological and some regarding usability. To overcome these barriers and generate products with greater wearability that are more efficient and accessible, factors are compiled through a review of publications and market research. The result of this analysis is a design methodology called Octopus, which ranks these factors and schematises them. Octopus provides a tool that can help define design requirements for multidisciplinary teams, generating a common framework and offering a new method of communication between them.
Path Planning for Non-Circular, Non-Holonomic Robots in Highly Cluttered Environments
Authors: Samaniego Ricardo , Lopez Joaquin , Vazquez Fernando
Published: August 2017

This paper presents an algorithm for finding a solution to the problem of planning a feasible path for a slender autonomous mobile robot in a large and cluttered environment. The presented approach is based on performing a graph search on a kinodynamic-feasible lattice state space of high resolution; however, the technique is applicable to many search algorithms. With the purpose of allowing the algorithm to consider paths that take the robot through narrow passes and close to obstacles, high resolutions are used for the lattice space and the control set. This introduces new challenges because one of the most computationally expensive parts of path search based planning algorithms is calculating the cost of each one of the actions or steps that could potentially be part of the trajectory. The reason for this is that the evaluation of each one of these actions involves convolving the robot’s footprint with a portion of a local map to evaluate the possibility of a collision, an operation that grows exponentially as the resolution is increased. The novel approach presented here reduces the need for these convolutions by using a set of offline precomputed maps that are updated, by means of a partial convolution, as new information arrives from sensors or other sources. Not only does this improve run-time performance, but it also provides support for dynamic search in changing environments. A set of alternative fast convolution methods are also proposed, depending on whether the environment is cluttered with obstacles or not. Finally, we provide both theoretical and experimental results from different experiments and applications.
TAMRA/TAMRA Fluorescence Quenching Systems for the Activity Assay of Alkaline Phosphatase
Authors: Shiba Akio , Kinoshita-Kikuta Emiko , Kinoshita Eiji , Koike Tohru
Published: August 2017

We introduce two types of fluorescence-quenching assay for alkaline phosphatases (APs) by using a carboxytetramethyl-rhodamine (TAMRA)-labeled phosphate-binding tag molecule (TAMRA-Phos-tag). In the first assay, TAMRA-labeled O-phosphorylethanolamine (TAMRA-PEA) was used as an artificial AP-substrate. TAMRA-Phos-tag specifically captured TAMRA-PEA to form a 1:1 complex at pH 7.4; the intensity of the fluorescence peak of the complex at 580 nm (λex = 523 nm) was significantly reduced to 32% of the average value for the two individual components as a result of the mutual approach of the TAMRA moieties. As TAMRA-PEA was dephosphorylated by AP, the resulting TAMRA-labeled ethanolamine dissociated and the fluorescence increased in a manner dependent on the AP dose and the time. In the second assay, pyrophosphate (PP), a natural AP-substrate, was used as a bridging ligand to form a dimeric TAMRA-Phos-tag complex. The dimerization reduced the fluorescence intensity to 49% of that in the absence of PP. As pyrophosphate was hydrolyzed to two orthophosphate moieties by AP, the 580-nm fluorescence recovered in a time-dependent manner. By examining the initial slope of this time-dependent fluorescence recovery, we succeeded in evaluating the 50% inhibitory concentrations of orthovanadate toward two AP isozymes under near-physiological conditions.
Alternative Energy Solutions Using BIPV in Apartment Buildings of Developing Countries: A Case Study of North Cyprus
Authors: Elinwa Ugochukwu , Radmehr Mehrshad , Ogbeba John
Published: August 2017

The growth in population of North Cyprus, and the increasing demand for housing, are two important factors that are rapidly shaping the development of the island. To meet this housing demand, contractors are resorting to high-rise apartment buildings as a housing solution. The study was carried out to investigate the possibilities of integrating PV systems into apartment buildings. This is a novel approach in housing within the context of North Cyprus. With the use of building information modelling (BIM) software, the possibility of this approach was tested. The study considered several cost variables and the advantages of building integrated photovoltaic (BIPV) systems integrated into apartment buildings at the design stage of the buildings. The willingness to pay (WTP) for this technology was also tested using qualitative methods and an economic analysis was carried out to ascertain the viability and feasibility of this technology. This was in line with present government policies using the net metering system. The method of analysis was carried out using a model proposed for BIPV integration in apartment buildings. The results derived from the survey data suggest that consumers prefer a price lower than €4500 for a 3 kWp integration of solar power equipment to their apartments.
Improving Thermal Comfort of Low-Income Housing in Thailand through Passive Design Strategies
Authors: Bhikhoo Nafisa , Hashemi Arman , Cruickshank Heather
Published: August 2017

In Thailand, the delivery of adequate low-income housing has historically been overshadowed by politics with cost and quantity being prioritised over quality, comfort and resilience. In a country that experiences hot and humid temperatures throughout the year, buildings need to be adaptable to the climate to improve the thermal comfort of inhabitants. This research is focused on identifying areas for improving the thermal performance of these housing designs. Firstly, dynamic thermal simulations were run on a baseline model using the adaptive thermal comfort model CIBSE TM52 for assessment. The three criteria defined in CIBSE TM52 were used to assess the frequency and severity of overheating in the buildings. The internal temperature of the apartments was shown to exceed the thermal comfort threshold for these criteria throughout the year. The internal operating daily temperatures of the apartment remain high, ranging from a maximum of 38.5 °C to a minimum of 27.3 °C. Based on these findings, five criteria were selected to be analysed for sensitivity to obtain the key parameters that influence the thermal performance and to suggest possible areas for improvement. The computer software package Integrated Environmental Solutions—Virtual Environment (IES-VE) was used to perform building energy simulations. Once the baseline conditions were identified, the software packages SimLab2.2 and RStudio were used to carry out the sensitivity analysis. These results indicated that roof material and the presence of a balcony have the greatest influence on the system. Incorporating insulation into the roof reduced the mean number of days of overheating by 21.43%. Removing the balcony increased the number of days of overheating by 19.94% due to significant reductions in internal ventilation.
Analysis of the Characteristics of Traditional Rural Constructions for Animal Corrals in the Adriatic-Ionian Area
Authors: Picuno Cosimo , Laković Ivan , Roubis Demetrios , Picuno Pietro , Kapetanović Aleksandra
Published: August 2017

The purpose of the present study is a comparative analysis of the characteristics of traditional rural constructions constituted by temporary settlements for animal corrals, employed for vertical transhumance or nomadic pastoralism, spread over the mountain regions of three different Countries of the Adriatic-Ionian area, i.e., Greece, Italy and Montenegro. The main methods applied in this research were the detection and typological survey of some examples of these rural constructions located in Southern Italy, whose typical dimensions, building material and constructive technologies were detected and analysed. Major findings of the research have been the identification of some similarities connecting architecture and building material of these constructions, which revealed common technologies applied by people from different countries that, despite different socio-economical and cultural traditions, have employed similar techniques, implementing simple but very effective constructive building principles. Main conclusions are connected to the possible restoration of these constructions that, designed over the centuries in order to fulfil their primary agricultural role, now constitute a widespread cultural heritage with a significant architectural value, influencing the agricultural environment and the visual perception of its landscape that, within the current re-discover of the agricultural heritage, may play a central role, even though new activities related to rural tourism.
Cloud Generalized Power Ordered Weighted Average Operator and Its Application to Linguistic Group Decision-Making
Authors: Gao Jianwei , Yi Ru
Published: August 2017

In this paper, we develop a new linguistic aggregation operator based on the cloud model for solving linguistic group decision-making problem. First, an improved generating cloud method is proposed so as to transform linguistic variables into clouds, which modifies the limitation of the classical generating cloud method. We then address some new cloud algorithms, such as cloud possibility degree and cloud support degree which can be respectively used to compare clouds and determine the weights. Combining the cloud support degree with power aggregation operator, we develop a new cloud aggregation operator dubbed the cloud generalized power ordered weighted average (CGPOWA) operator. We study the properties of the CGPOWA operator and investigate its family including a wide range of aggregation operators such as the CGPA operator, CPOWA operator, CPOWGA operator, CPWQA operator, CWAA and CWGA operator. Furthermore, a new approach for linguistic group decision-making is presented on the basis of the improved generating cloud method and CGPOWA operator. Finally, an illustrative example is provided to examine the effectiveness and validity of the proposed approach.
Intuitionistic-Fuzzy Goals in Zero-Sum Multi Criteria Matrix Games
Authors: Bashir Zia , Wątróbski Jarosław , Rashid Tabasam , Sałabun Wojciech , Ali Jawad
Published: August 2017

The classical matrix theory is deficient to express the vagueness of the real life. The fuzzy set theory has been successfully applied to bridge this gap. Much work has already been done on a two-person zero sum matrix game with fuzzy goals. In continuation, this paper is dedicated to define and study a multi-criteria two-person zero sum game with intuitionistic fuzzy goals. It is shown that solving such games is equivalent to solving two crisp multi object linear programming problems. Our work generalizes the previous study on a multi-criteria game with fuzzy goals by adopting the approach of linear programming with intuitionistic fuzzy sets. Finally, an illustrative numerical example is provided to elaborate the proposed approach.
Do 16 Polycyclic Aromatic Hydrocarbons Represent PAH Air Toxicity?
Authors: Samburova Vera , Zielinska Barbara , Khlystov Andrey
Published: August 2017

Estimation of carcinogenic potency based on analysis of 16 polycyclic aromatic hydrocarbons (PAHs) ranked by U.S. Environmental Protection Agency (EPA) is the most popular approach within scientific and environmental air quality management communities. The majority of PAH monitoring projects have been focused on particle-bound PAHs, ignoring the contribution of gas-phase PAHs to the toxicity of PAH mixtures in air samples. In this study, we analyzed the results of 13 projects in which 88 PAHs in both gas and particle phases were collected from different sources (biomass burning, mining operation, and vehicle emissions), as well as in urban air. The aim was to investigate whether 16 particle-bound U.S. EPA priority PAHs adequately represented health risks of inhalation exposure to atmospheric PAH mixtures. PAH concentrations were converted to benzo(a)pyrene-equivalent (BaPeq) toxicity using the toxic equivalency factor (TEF) approach. TEFs of PAH compounds for which such data is not available were estimated using TEFs of close isomers. Total BaPeq toxicities (∑88BaPeq) of gas- and particle-phase PAHs were compared with BaPeq toxicities calculated for the 16 particle-phase EPA PAH (∑16EPABaPeq). The results showed that 16 EPA particle-bound PAHs underrepresented the carcinogenic potency on average by 85.6% relative to the total (gas and particle) BaPeq toxicity of 88 PAHs. Gas-phase PAHs, like methylnaphthalenes, may contribute up to 30% of ∑88BaPeq. Accounting for other individual non-EPA PAHs (i.e., benzo(e)pyrene) and gas-phase PAHs (i.e., naphthalene, 1- and 2-methylnaphthalene) will make the risk assessment of PAH-containing air samples significantly more accurate.
Establishment of an Inventory for the Life Cycle Cost (LCC) Analysis of a Water Supply System
Authors: Lee Hyundong , Shin Hongcheol , Rasheed Usman , Kong Myeongsik
Published: August 2017

This paper aimed to develop an inventory that is necessary for the life cycle cost (LCC) analysis of a water supply system. Based on an established inventory system, data items for each asset category were defined. The water supply system was divided into pipelines, pumps and distribution facilities. Pipeline facilities that account for the majority of water supply systems were grouped, according to the purposes and functions of pipes, into conveyance facilities, transmission facilities, distribution facilities and supply facilities. The inventory of water supply systems were divided into five levels, and the higher the level, the more detailed facilities were classified. Basically, 12 items and diagnosis results were included in the system to distinguish the characteristics of each asset, and it was ensured that administrators could add or change items later if necessary. The data used in this study were established based on real data from the Yeong-Wol (YW) pipeline systems.
Understanding the Temperature Variations and Thermal Structure of a Subtropical Deep River-Run Reservoir before and after Impoundment
Authors: Xie Qike , Liu Zhaowei , Fang Xing , Chen Yongcan , Li Chong , MacIntyre Sally
Published: August 2017

A two-dimensional hydrodynamic CE-QUAL-W2 model was configured for a deep subtropical river-run reservoir, the Xiluodu Reservoir (XLDR), in China to simulate water temperature in the first two years of impoundment (2013–2014) using measured data as model input. It was calibrated using observed temperature profiles near the dam and the outflow temperatures. Observed daily temperatures at four gauging stations upstream or downstream of XLDR before (2000–2012) and after the impoundment (4 May 2013) were analyzed and fitted with a sine function representing seasonal temperature variation. The fitted annual temperature phase shifts showed no phase delay in XLDR area before the impoundment but revealed a phase delay about 17 days between outflow and inflow after the impoundment, which was not caused by the air temperature variation. The simulated temperatures verified a similar phase delay after the impoundment. The simulated temperatures, water ages, and vertical temperature gradients demonstrated an average metalimnetic deepening rate of 0.49 m/day (average inflow ~4500 m3/s) while the largest rate due to massive inflow (~15,000 m3/s) was 1.67 m/day. The W2 model was run under hypothetic scenarios of different inflow/outflow rates and outflow withdrawn elevations. The results revealed that greater inflow/outflow rate could lead to higher metalimnetic deepening rate and smaller outflow phase delay, while deeper outflow withdrawn could lead to deeper metalimnion and larger epilimnetic depth.
A Web Based Interface for Distributed Short-Term Soil Moisture Forecasts
Authors: Sommerlot Andrew , Easton Zachary
Published: August 2017

Agricultural non-point source (NPS) pollution is a source of water quality impairment, and demonstrates widely varying spatial and temporal pollution potential. Many efforts to protect water quality are based on seasonal and annual estimates of pollutant loss potential (NRCS 590 nutrient management standard, P-Index) that inadequately address the hydrologic processes driving NPS pollution. One barrier to adopting practices that address NPS pollution is a lack of tools capable of transferring information at sufficient spatial and temporal resolution so that end-users can make informed decisions. We introduce a web-based system displaying distributed hydrologic forecasts using free and open source software. The system consists of three primary components: (1) a hydrology model that provides short-term distributed forecasts; (2) a data structure capable of re-structuring large, high resolution rasters; (3) an interface employing adaptive map-viewing technology that allows end-users to interact with the data to avoid high-risk areas when planning agricultural practices.
Agreement of Four Equations for Computing Dewfall in Northern Germany
Authors: Xiao Huijie , Meissner Ralph , Borg Heinz , Wang Ruoshui , Cao Qiqi
Published: August 2017

The energy balance (EB), turbulent vapour transport (TVT), Penman-Monteith (PM) and Bowen ratio energy balance (BREB) equation were used to estimate dewfall based on meteorological data. Initially there were big disagreements between the estimates from these four equations. However, after multiplying the heat and vapour conductance terms by 0.33 the agreement was much better. This implies that the disagreements derived from improper conductance values. Initially we did not consider the effect of atmospheric stability on the conductances. With stability correction the conductances were on average 0.5 times the values without stability correction. To arrive at the aforementioned 0.33, the conductances with stability correction still need to be lower by a factor of 0.66. The value of the von Karman constant and the relationships for the zero plane displacement and the roughness length we used in our conductance computations are widely used, but not the only possible ones. With different values and relationships also suggested in the literature one can reach this factor. However, it is also possible that our wind speed data contributed to the fact that the conductances we computed were too high. Their computation for a given canopy—atmosphere system requires wind speeds from a wind profile in equilibrium with the vegetation. This in turn requires an adequate fetch around the investigated surface. The highly varied vegetation in and around the site where the study was conducted makes adequate fetch rather doubtful. To obtain valid conductance values the atmospheric stability conditions must be considered, the appropriate values for the von Karman constant, the zero plane displacement and roughness length must be used, and there must be adequate fetch. The BREB equation does not contain a conductance term and therefore does not suffer from the problems just stated. The other three equations do. However, the BREB, like the EB and TVT equations, need the surface temperature which is not routinely measured. This then leaves the PM equation from which this temperature has been eliminated as the only option. Hence, in a future study dewfall estimates from the PM equation should be compared with direct measurements with a high precision weighing lysimeter.
Effect of the fluorination technique on the surface-fluorination patterning of double-walled carbon nanotubes
Authors: Bulusheva Lyubov G , Fedoseeva Yuliya V , Flahaut Emmanuel , Rio Jérémy , Ewels Christopher P , Koroteev Victor O , Van Lier Gregory , Vyalikh Denis V , Okotrub Alexander V
Published: August 2017

Double-walled carbon nanotubes (DWCNTs) are fluorinated using (1) fluorine F2 at 200 °C, (2) gaseous BrF3 at room temperature, and (3) CF4 radio-frequency plasma functionalization. These have been comparatively studied using transmission electron microscopy and infrared, Raman, X-ray photoelectron, and near-edge X-ray absorption fine structure (NEXAFS) spectroscopy. A formation of covalent C–F bonds and a considerable reduction in the intensity of radial breathing modes from the outer shells of DWCNTs are observed for all samples. Differences in the electronic state of fluorine and the C–F vibrations for three kinds of the fluorinated DWCNTs are attributed to distinct local surroundings of the attached fluorine atoms. Possible fluorine patterns realized through a certain fluorination technique are revealed from comparison of experimental NEXAFS F K-edge spectra with quantum-chemical calculations of various models. It is proposed that fluorination with F2 and BrF3 produces small fully fluorinated areas and short fluorinated chains, respectively, while the treatment with CF4 plasma results in various attached species, including single or paired fluorine atoms and –CF3 groups. The results demonstrate a possibility of different patterning of carbon surfaces through choosing the fluorination method.