bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Budaya Kerja dan Motivasi Terhadap Produktivitas Kerja Karyawan Di KFC Dermaga Point Palembang
Authors: Romadon Imam , Mulyani Agus , Usman Benny , Ilhamsyah Ilhamsyah
Published: August 2024

ABSTRACTÂ The population and sample of this study were all employees at KFC Dermaga Point Palembang, totaling 35 employees. This study amounted to 35 respondents who were taken using saturated sampling. The data studied used questionnaire data from KFC Dermaga Point Palembang employees. Data analysis was carried out by quantitative analysis method using SPSS version 23 program. The results of the study can be seen that there is a significant influence between work culture and work motivation, either partially or jointly on employee productivity at KFC Dermaga Point Palembang. From the calculation results, it can be seen that the correlation coefficient (R) is 0.663 % or 66.3%, which means that the relationship between work culture variables and work motivation is sufficient for employee productivity. While the coefficient of determination is obtained at 0.439% or 43.9%, which means that work culture and work motivation have a very sufficient effect. While the remaining 56.1% was contributed by other factors not examined such as motivation factors, competence factors, communication factors, and discipline factors.Â Keywords: Work Culture, Work Motivation, Work Productivity.Â Â ABSTRAKÂ Populasi dan sampel penelitian ini adalah seluruh karyawan di KFC Dermaga Point Palembang yang berjumlah 35 karyawan. Penelitian ini berjumlah 35 responden yang diambil menggunakan sampling jenuh. Data yang diteliti menggunakan data kuesioner karyawan KFC Dermaga Point Palembang. Analisis data dilakukan dengan metode analisis kuantitatif menggunakan program SPSS versi 23. Hasil penelitian dapat diketahui bahwa ada pengaruh yang signifikan antara budaya kerja dan motivasi kerja baik secara parsial maupun secara bersama - sama terhadap produktivitas karyawan pada KFC Dermaga Point Palembang. Dari hasil perhitungan dapat diketahui bahwa koefisien korelasi (R) sebesarÂ  0,663 % atau 66,3% yang berarti hubungan variabel budaya kerja dan motivasi kerja cukupÂ  terhadap produktivitas karyawan. Sedangkan koefisien determinasi diperoleh sebesar 0,439 % atau 43,9 % yang berarti budaya kerja dan motivasi kerjaÂ Â  berpengaruh sangat cukup. Sedangkan sisanya 56,1 % disumbangkan oleh faktor faktor lain yang tidak diteliti seperti faktor motivasi, faktor kompetensi, faktor komunikasi, dan faktor disiplin.Â Kata Kunci : Budaya Kerja, Motivasi Kerja, Produktivitas Kerja.
Analisis Faktor Yang Mempengaruhi Manajemen Pajak Dengan Indikator Tarif Pajak Efektif Pada Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia Periode 2016-2018
Authors: Mahdiah Mahdiah , Darmawati Tri , Kurbani Adie
Published: August 2024

ABSTRACTÂ This study examines and analyzes the effect of company size, profitability and intensity of fixed assets, while profitability is described by Return On Assets (ROA) on tax management with an indicator of effective tax rates in manufacturing companies listed on the Indonesia Stock Exchange for the period 2016-2018. The population of this research is manufacturing companies in the food & beverage sector on the Indonesia Stock Exchange for the period 2016-2018. Sampling in this study using purposive sampling method and obtained 14 companies, with 3 years of observation, there were 11 outlier data. So that the total of those studied was 33. Data analysis was carried out by classical assumption test, simple linear regression, multiple linear regression analysis test, Correlation Coefficient, Hypothesis Test and Coefficient of Determination. The results of this study indicate that company size and the intensity of fixed assets have an effect on tariffs. Â Keywords: effective tax rate, company size, profitability, intensity of fixed assetsÂ Â ABSTRAKÂ Penelitian ini menguji dan menganalisis pengaruh ukuran perusahaan, profitabilitas dan intensitas aset tetap sementara itu Profitabilitas yang digambarkan oleh Return On Assets (ROA) terhadap manajemen pajak dengan indikator tarif pajak efektif pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia periode 2016-2018. Populasi dari penelitian ini adalah perusahan manufaktur pada sektor makanan & minuman di Bursa Efek Indonesia periode 2016-2018. Pengambilan sampel pada penelitian ini dengan metode purposive sampling dan didapatkan 14 perusahaan, dengan 3 tahun pengamatan, terdapat data outlier sebanyak 11. Sehingga total dari yang diteliti sebanyak 33. Analisis data yang dilakukan dengan uji Asumsi Klasik, Regresi Linier Sederhana, Uji AnalisisgRegresisLinier Berganda, Koefisien Korelasi, Uji Hipotesis dan Koefisien Determinasi. Hasil dari penelitian ini menunjukan bahwa ukuran perusahaan dan intensitas aset tetap berpengaruh terhadap tariff.Â Kata kunci : tarif pajak efektif, ukuran perusahaan, profitabilitas, intensitas asetÂ  tetap
РОЛЬ БЕЗПЕЧНОГО ОСВІТНЬОГО СЕРЕДОВИЩА У ФОРМУВАННІ ЗДОРОВ’ЯЗБЕРЕЖУВАЛЬНОЇ КОМПЕТЕНТНОСТІ ЗДОБУВАЧІВ ОСВІТИ
Authors: БУЧКІВСЬКА Галина , БАЛУХ Микола
Published: August 2024

В статті розглядаються питання освітньої політики держави для забезпечення гарантій прав здобувачів освіти на досягнення якісної освіти за умови психологічної та фізичної безпеки. Показано, що комфортність і безпека освітнього середовища закладу освіти забезпечуються єдністю дій усіх учасників освітнього процесу.
Проаналізовано, що у всьому світі широко обговорюється тема здоров’я молоді. Розглянуто, що педагоги не залишаються осторонь проблеми формування основ здорового способу життя. Закон України «Про освіту» серед основних принципів державної політики в галузі освіти проголошує «пріоритет ... життя та здоров’я людини» і встановлює, що заклад освіти несе відповідальність за життя та здоров’я здобувачів освіти під час освітнього процесу і створює умови, що гарантують охорону та зміцнення здоров’я здобувачів освіти.
Визначено здоров’язбережувальне освітнє середовище як сукупність управлінських, організаційних, навчальних та оздоровчих умов, спрямованих на формування, зміцнення та збереження соціального, фізичного, психічного здоров’я здобувачів освіти, педагогів на основі психолого-педагогічних та медико-фізіологічних засобів та методів супроводу освітнього процесу, профілактики факторів ризику, реалізації комплексу міжвідомчих заходів щодо створення соціально-адаптованого освітнього середовища.
Акцентовано, що підготовка майбутнього вчителя до розробки і створення здоров’язбережувального освітнього середовища в закладі освіти передбачає забезпечення умов для формування їхньої здоров’язбережувальної компетентності на основі традиційних та інноваційних технологій, що забезпечують збереження здоров’я учнів.
Розкрито, що інтегрована характеристика педагогічної діяльності педагога охоплює не тільки його професійні особливості, але й забезпечує впровадження здорового способу життя, зміцнення здоров’я учасників освітнього процесу та формує в них ціннісного ставлення до здоров’я та здорового образу життя. Сформована здоров’язбережувальна компетентність є складником структурованої системи професійних компетентностей  педагога.
ЗАСОБИ ФІЗИЧНОЇ ТЕРАПІЇ ПРИ ОСТЕОХОНДРОЗІ ШИЙНОГО ВІДДІЛУ ХРЕБТА З КАРДІАЛЬНИМ СИНДРОМОМ
Authors: ГРЕЙДА Наталія , ЛАВРИНЮК Володимир , КИРИЛЮК Вікторія
Published: August 2024

В структурі захворювань остеохондроз з кардіальним синдромом займає особливе місце, так як кількість хворих з кожним роком збільшується, що зумовлює погіршення якості життя.
Мета дослідження – визначити основні засоби фізичної терапії при остеохондрозі шийного відділу хребта з кардіальним синдромом.  
Фізична терапія відіграє важливу роль у профілактиці та лікуванні остеохондрозу шийного відділу хребта з кардіальним синдромом. При підборі засобів фізичної терапії, таких як терапевтичні вправи, гідрокінезитерапія, сегментарно-рефлекторний масаж, мануальні техніки, фізіотерапія, потрібно враховувати гостороту клінічних проявів. У протіканні захворювання розрізняють гострий період, підгострий період, період клінічного одужання. У госторому періоді шийний відділ хребта потребує забезпечення спокою та відсутності навантаження. У підгострому періоді рекомендується виконання терапевтичних вправ з мінімальною амплітудою та з полегшених вихідних положень, поступове введення в програму реабілітації виконання мануальних технік та масажу з мінімальним натиском. В міру покращення фізичного стану та тренованості організму збільшують навантаження, переходять до виконання статичних навантажень для зміцнення м’язів шиї, тулуба та плечового появу верхніх кінцівок. Під час проведення сегментарно-рефлекторного масажу та мануальної терапії окрім м’язів шиї задіюють м’язи спини та верхньої кінцівки. Фізіотерапію використовують як допоміжний засіб фізичної терапії з метою розслаблення поверхневих м'язів, зменшення болю та покращення кровообігу.
ЕФЕКТИВНІСТЬ РЕАБІЛІТАЦІЙНОЇ ІГРОВОЇ СИСТЕМИ У ФІЗИЧНІЙ ТЕРАПІЇ ПАЦІЄНТІВ ПІСЛЯ ІШЕМІЧНОГО ІНСУЛЬТУ
Authors: ТОЦЬКА Анна , ТЕРЕНТЮК Вадим , КАРАНДА Віталій , ГАСИЧ Олександр
Published: August 2024

На сьогоднішній день в Україні, як і в інших країнах світу, є тенденція до зростання кількості неврологічних захворювань, в структурі яких гостре порушення мозкового кровообігу є найбільш актуальним та соціально значущим. Мета дослідження: визначити ефективність реабілітаційної ігрової системи у ерготерапії пацієнтів після ішемічного інсульту. Методи дослідження: теоретичний аналіз та узагальнення науково-методичної  літератури, функціональні тести оцінювання пацієнтів (MOCA, Фугл-Мейер, Box&blocks, 9 hole peg test), педагогічний експеримент, методи математичної статистики. Результати роботи. Результат тестування пацієнтів за Монреальською шкалою оцінки когнітивних функцій достовірно поліпшився упродовж дослідження на 9,65 балів (p < 0,001) у пацієнтів з ішемічним інсультом. Упродовж дослідження показники тесту Фугл-Мейра достовірно поліпшилися на 21,42 бали (p<0,001) у пацієнтів з ішемічним інсультом переважно за рахунок моторних навичок верхньої кінцівки, поліпшення рухової симетрії та координації. Результат тесту 9 hole peg test для ураженої кінцівки пацієнта з ішемічним інсультом вірогідно поліпшився на 10,72 секунди (p<0,05), водночас для неураженої кінцівки – на 12,85 секунд (p < 0,05), що було статистично достовірно. За результатами повторного аналізу показників Box&Block тесту не вдалося зафіксувати вірогідні зміни за цим тестом для жодної з кінцівок, зокрема показник для ураженої кінцівки поліпшився на  6,22 блоків (p >0,05), для неураженої – на 10,07 блоків (p>0,05).Висновки. Таким чином, ігрові реабілітаційні системи є ефективними інструментами для поліпшення моторних функцій, координації та когнітивних процесів у пацієнтів з ішемічним інсультом. Вони також можуть забезпечити нові можливості для дослідження моторного навчання та нейропластичності в контексті реабілітації.
“BOXING DAY” В АНГЛІЙСЬКОМУ ФУТБОЛІ
Authors: НАКОНЕЧНИЙ Роман , ХАРЧЕНКО-БАРАНЕЦЬКА Людмила , СИНИЦЯ Андрій
Published: August 2024

Аналізуючи наявні дослідження у футболі, нами не виявлено пов’язаних із з’ясуванням ролі “Boxing Day” в межах проведення одного з найкращих чемпіонатів з футболу у Світі. Мета дослідження: з’ясувати переваги та недоліки  “Boxing Day” в Англійському футболі. Методи дослідження: аналіз і синтез, порівняння та узагальнення. Результати. Досягнення високих результатів у футболі залежить не лише від рівня підготовленості гравців (технічної, тактичної, фізичної, психічної та теоретичної)  але  й календаря змагань, що стає однією з ключових складових успіху команди. Особливо це стосується чемпіонатів, де рівень клубів суттєво не відрізняється одне від одного. Щоб виграти такі змагання потрібно протягом усього сезону (9-10 місяців) демонструвати найвищий рівень гри, що вкрай складно. Таке явище як “Boxing Day” коли команди повинні грати декілька матчів за найменший проміжок часу можуть внести свої корективи у розподіл місць по завершенню сезону. Висновок. З однієї сторони складний передноворічний графік в “АПЛ” небезпечний: надмірним фізичним навантаженням; відсутністю ефективного відновлення гравців; високим ризиком травматизму футболістів тощо. З іншого, керівники ліги вважають недоцільним відмовлятись від цієї події тому, що це: свято для вболівальників; важливе дійство для трансляторів та значна стаття прибутків.
EXPERIMENTAL STUDY OF THE UTILIZATION OF PINEAPPLE LEAF FIBER WITH THE ADDITION OF EPOXY RESIN TO THE TENSILE STRENGTH BREAK OF THE CONCRETE
Authors:   Universitas Indo Global Mandiri, Nisumanti Sartika , Hasanah Miftahul ,   Universitas Indo Global Mandiri, Febryandi Febryandi ,   Universitas Indo Global Mandiri
Published: August 2024

In its development, many new concrete modifications were found, such as lightweight concrete, fiber concrete, polymer concrete, high-strength concrete and ultra-high-strength concrete. Epoxy resin can accelerate the hardening process of concrete because epoxy itself generates heat so that it helps accelerate hardening. In previous studies, the addition of areca nut shell fiber and 0.8% epoxy resin can increase the split tensile strength of concrete. Based on the description above, it is necessary to conduct research on the split tensile strength of concrete that combines a mixture of pineapple leaf fiber and epoxy resin. So this research uses pineapple leaf fiber and epoxy resin. Pineapple leaf fiber and epoxy resin are expected to be strength-enhancing materials that can produce concrete with more optimal split tensile strength. The purpose of this study was to determine the effect of the addition of epoxy resin and the percentage variation of pineapple leaf fiber on the split tensile strength of concrete and its comparison with normal concrete and to determine the percentage level of the addition of the most optimum pineapple leaf fiber to produce the maximum concrete split tensile strength test value among the planned variations. The method used in this research is experimental. From the results of the average split tensile strength test at 28 days, the epoxy resin variation of 0.8% achieved a strength of 2.87 MPa, the 0.15% variation achieved 2.37 MPa, and the 0.5% variation achieved 2.47 MPa.
Analisis Representasi Matematis Siswa Dalam Menyelesaikan Soal Matematika Di SMP Negeri 3 Kadipaten
Authors: Eko Dirmansyah Mario
Published: August 2024

Tujuan penelitian ini mendeskripsikan kemampuan representasi gambar, simbolik dan verbal peserta didik dalam menyelesaikan soal matematika pada materi fungsi Penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif. Populasi dalam penelitian ini adalah siswa kelas VIII SMP Negeri 3 Kadipaten, dengan sampel sebanyak 28 siswa. Data Penelitian ini dikumpulkan melalui tes tertulis dan wawancara. Hasil penelitian Kemampuan respresentasi visual SMPN 3 Kadipaten pada siswa kelas VIII A didapat nilai rata-rata sebesar 28,15 atau 56,30%, berdasarkan hasil tersebut kategori kemampuan respresentasi visual SMPN 3 Kadipaten pada siswa kelas VIII A termasuk kedalam kategori rendah. Kemampuan respresentasi simbolik SMPN 3 Kadipaten pada siswa kelas VIII A didapat nilai rata-rata sebesar 3,70 atau 18,52%, berdasarkan hasil tersebut kategori kemampuan respresentasi simbolik SMPN 3 Kadipaten pada siswa kelas VIII A termasuk kedalam kategori sangat rendah. Kemampuan respresentasi verbal SMPN 3 Kadipaten pada siswa kelas VIII A didapat nilai rata-rata sebesar 8,52 atau 28,40%, berdasarkan hasil tersebut kategori kemampuan respresentasi verbal SMPN 3 Kadipaten pada siswa kelas VIII A termasuk kedalam kategori sangat rendah.
Profile of numeration ability in solving trigonometry questions in class x smk 4 semarang examined by initial mathematical ability
Authors: Arumningsih Eys
Published: August 2024

This study aims to analyze students' mathematical numeracy skills in solving trigonometry problems among 10th-grade vocational high school students, based on their initial mathematical abilities. Students were categorized into three groups based on their initial mathematical ability: (1) high ability, (2) moderate ability, and (3) low ability. This qualitative descriptive study involved 33 students as subjects, with a sample size of 6 students. Data collection utilized test techniques, specifically using summative assessment instruments to assess initial mathematical abilities through trigonometry problems, and numeracy skills through trigonometry-related test questions. Data analysis employed a triangulation technique involving data reduction, data presentation, and conclusion drawing. The findings indicated that in solving trigonometry problems: (1) Students with high mathematical ability were able to fulfill all numeracy skill indicators, evident from their accurate and sequentially correct answers. (2) Students with moderate mathematical ability could not fulfill some numeracy skill indicators, as evidenced by partially correct answers. (3) Students with low mathematical ability could only fulfill some numeracy skills; these students tended to encounter difficulties in problem-solving.In summary, the study demonstrated varying levels of numeracy skills in relation to students' initial mathematical abilities when solving trigonometry problems.
Neoadjuvant versus Adjuvant Therapy for Stage IIIB-IIID Melanoma
Authors: Patel Bhumik , Upadhyaya Sangnya
Published: August 2024

The treatment landscape for advanced stage melanoma is rapidly evolving due to advancements in our understanding of melanoma biology and the emergence of novel therapies. This necessitates a comprehensive review to guide clinicians in adopting evidence based and patient centric approaches to treat stage IIIB-IIID melanoma. A literature review was conducted to synthesize current information on the most optimal treatment available. Data available from different clinical trials found that neoadjuvant therapy was a more effective treatment compared to adjuvant therapies alone. Furthermore, neoadjuvant therapy with combination therapy was more efficacious in producing a complete pathological response compared to monotherapy. A follow-up study on patients treated with neoadjuvant therapy with PD1 inhibitor pembrolizumab found that patients who produced a major pathologic response (MPR) or complete response (pCR) had higher 5 year Overall Survival rates. The trial highlights the importance of tailoring pharmacological treatment to patients to receive a significant pathological response. In addition, finding robust biomarkers is important in assessing therapies to personalize them to the patient. Longer term follow-up should be emphasized due to observed differences in median time to recurrence.
Pediatric Neurotropic Infection Alters Synaptic Development in the Developing Brain
Authors: Fadare Anuoluwapo Grace , Kamte Yashika S. , Chandwani Manish N. , O'Donnell Lauren A.
Published: August 2024

Many neurotropic viruses cause more significant pathology in younger hosts as their brains are still developing. This experiment asked how central nervous system (CNS) viral-infections affect the development of synapses in the pediatric brain during infection and post-infection. Synaptogenesis is at its peak in pediatric mice (10 days old) and we hypothesized that a neurotropic infection could disrupt synaptic proteins. We used a transgenic mouse model where measles virus (MV) infects only mature neurons, leading us to question whether synapses were impacted. We examined synaptic markers in the cerebellum and hippocampus in MV-infected and uninfected mice 9 days and 90 days post-infection through western blot analysis. We found differential downregulation of pre-synaptic proteins (synapsins 1, 2 and 3) during infection, which was dependent on the brain region and the time point examined. This highlights the short and long-term consequences of a pediatric infection on neurodevelopment and potential dysregulation of synaptogenesis.
National Inpatient Sample Analysis: Examining Clinical Outcomes in Cardiac Ablation Patients with Hyperlipidemia
Authors: Elias Tony , Elmalh Mena , Girgis Kyrillos , Syed Taha , Beshai Rafail
Published: August 2024

Background Cardiac ablation, utilizing radiofrequency or cryoablation, is a therapeutic approach for correcting abnormal heart rhythms by disrupting specific electrical pathways within the heart. Despite the growing utilization of cardiac ablation, limited research exists on the impact of hyperlipidemia, a prevalent cardiovascular risk factor, on outcomes in patients undergoing this procedure. Previous studies underscore the importance of understanding how comorbid conditions, such as hyperlipidemia, influence the efficacy and safety of cardiac ablation.1,2 Consequently, this study aimed to leverage the national inpatient sample database to investigate in-hospital outcomes among cardiac ablation patients with hyperlipidemia. Methods Data from the National Inpatient Sample (NIS) Database for 2019 and 2020 were extracted to identify adult patients who underwent cardiac ablation, stratified based on a concomitant diagnosis of hyperlipidemia using international classification of diseases 10th revision codes. Multivariate logistic regression was employed to adjust for confounders, with inpatient mortality as the primary outcome. Statistical analyses were conducted using SPSS software. Results The study encompassed 25,754 cardiac ablation patients, of whom 14,800 (57.4%) had hyperlipidemia. Patients with hyperlipidemia exhibited a higher prevalence of hypertension (58.8% vs. 51%, P Conclusions This nationally representative retrospective cohort study highlights the association between hyperlipidemia and adverse outcomes, including increased mortality, among patients undergoing cardiac ablation. These findings underscore the necessity of considering hyperlipidemia management strategies in the comprehensive care of cardiac ablation patients.
Stability and optimal decay rates for abstract systems with thermal damping of Cattaneo’s type
Authors: Deng Chenxi , Han Zhong-Jie , Kuang Zhaobin , Zhang Qiong
Published: August 2024

This paper studies the stability of an abstract thermoelastic system with Cattaneo’s law, which describes finite heat propagation speed in a medium. We introduce a region of parameters containing coupling, thermal dissipation, and possible inertial characteristics. The region is partitioned into distinct subregions based on the spectral properties of the infinitesimal generator of the corresponding semigroup. By a careful estimation of the resolvent operator on the imaginary axis, we obtain distinct polynomial decay rates for systems with parameters located in different subregions. Furthermore, the optimality of these decay rates is proved. Finally, we apply our results to several coupled systems of partial differential equations.
Evaluating the efficacy of the punch-out technique in systemic-to-pulmonary shunts: A computational fluid dynamics approach
Authors: Yamazaki Shiho , Kowatari Ryosuke , Yano Tetsuya , Sasaki Hanae , Daitoku Kazuyuki , Minakawa Masahito
Published: August 2024

BACKGROUND: Systemic-to-pulmonary shunt is a palliative procedure used to decrease pulmonary blood flow in congenital heart diseases. Shunt stenosis or occlusion has been reported to be associated with mortality; therefore, the management of thrombotic complications remains a challenge for most congenital cardiovascular surgeons. Despite its importance, the optimal method for shunt anastomosis remains unclear. OBJECTIVE: The study investigates the clinical benefits of the punch-out technique over conventional methods in the anastomosis process of Systemic-to-pulmonary shunt, focusing on its potential to reduce shunt-related complications. METHODS: Anastomotic models were created by two different surgeons employing both traditional slit and innovative punch-out techniques. Computational tomography was performed to construct three-dimensional models for computational fluid dynamics (CFD) analysis. We assessed the flow pattern, helicity, magnitude of wall shear stress, and its gradient. RESULTS: The anastomotic flow area was larger in the model using the punch-out technique than in the slit model. In CFD simulation, we found that using the punch-out technique decreases the likelihood of establishing a high wall shear stress distribution around the anastomosis line in the model. CONCLUSION: The punch-out technique emerges as a promising method in SPS anastomosis, offering a reproducible and less skill-dependent alternative that potentially diminishes the risk of shunt occlusion, thereby enhancing patient outcomes.
Predicting Conversion Time from Mild Cognitive Impairment to Dementia with Interval-Censored Models
Authors: Zhang Yahui , Li Yulin , Song Shangchen , Li Zhigang , Lu Minggen , Shan Guogen
Published: August 2024

Background:

Mild cognitive impairment (MCI) patients are at a high risk of developing Alzheimer’s disease and related dementias (ADRD) at an estimated annual rate above 10%. It is clinically and practically important to accurately predict MCI-to-dementia conversion time.

Objective:

It is clinically and practically important to accurately predict MCI-to-dementia conversion time by using easily available clinical data.

Methods:

The dementia diagnosis often falls between two clinical visits, and such survival outcome is known as interval-censored data. We utilized the semi-parametric model and the random forest model for interval-censored data in conjunction with a variable selection approach to select important measures for predicting the conversion time from MCI to dementia. Two large AD cohort data sets were used to build, validate, and test the predictive model.

Results:

We found that the semi-parametric model can improve the prediction of the conversion time for patients with MCI-to-dementia conversion, and it also has good predictive performance for all patients.

Conclusions:

Interval-censored data should be analyzed by using the models that were developed for interval- censored data to improve the model performance.
Assessing the Linguistic Capacity Across Alzheimer’s Disease and Its Preclinical Stages: Evidence from Narrative Macrostructure in Elderly Speakers of Greek
Authors: Kaltsa Maria , Tsolaki Anthoula , Lazarou Ioulietta , Mittas Ilias , Papageorgiou Mairi , Papadopoulou Despina , Tsimpli Ianthi Maria , Tsolaki Magda
Published: August 2024

Background: The assessment of language deficits can be valuable in the early clinical diagnosis of neurodegenerative disorders, including Alzheimer’s disease (AD). Objective: The present study aims to explore whether language markers at the macrostructural level could assist with the placement of an individual across the dementia continuum employing production data from structured narratives. Methods: We administered a Picture Sequence Narrative Discourse Task to 170 speakers of Greek: young healthy controls (yHC), cognitively intact healthy elders (eHC), elder participants with subjective cognitive impairment (SCI), with mild cognitive impairment (MCI), and with AD dementia at the mild/moderate stages. Structural MRIs, medical history, neurological examination, and neuropsychological/cognitive screening determined the status of each speaker to appropriately groupthem. Results: The data analysis revealed that the Macrostructure Index, Irrelevant Info, and Narration Density markers can track cognitive decline and AD (p < 0.001; Macrostructural Index: eHC versus AD Sensitivity 93.8%, Specificity 74.4%, MCI versus AD Sensitivity 93.8%, Specificity 66.7%; Narration Density: eHC versus AD Sensitivity 90.6%, Specificity 71.8%, MCI versus AD Sensitivity 93.8%, Specificity 66.7%). Moreover, Narrative Complexity was significantly affected for subjects with AD, Irrelevant Info increased in the narrations of speakers with MCI and AD, while Narration Length did not appear to indubitably differentiate between the cognitively intact groups and the clinical ones. Conclusions: Narrative Macrostructure Indices provide valuable information on the language profile of speakers with(out) intact cognition revealing subtle early signs of cognitive decline and AD suggesting that the inclusion of language-based assessment tools would facilitate the clinical process.
Geographic Variation of Prevalence of Alzheimer’s Disease and Related Dementias in Central Appalachia
Authors: Wing Jeffrey J. , Rajczyk Jenna I. , Burke James F.
Published: August 2024

Background:

Alzheimer’s disease and related dementias (ADRD) prevalence varies geographically in the United States.

Objective:

To assess whether the geographic variation of ADRD in Central Appalachia is explained by county-level sociodemographics or access to care.

Methods:

Centers for Medicare and Medicaid Services Public Use Files from 2015– 2018 were used to estimate county-level ADRD prevalence among all fee-for-service (FFS) beneficiaries with≥1 inpatient, skilled nursing facility, home health agency, hospital outpatient or Carrier claim with a valid ADRD ICD-9/10 code over three-years in Central Appalachia (Kentucky, North Carolina, Ohio, Tennessee, Virginia, and West Virginia). Negative binomial regression was used to estimate prevalence overall, by Appalachian/non-Appalachian designation, and by rural/urban classification. Models were then adjusted for county-level: 1) FFS demographics (age, gender, and Medicaid eligibility), comorbidities; 2) population sociodemographics (race/ethnicity, education, aging population distribution, and renter-occupied housing); and 3) diagnostic access (PCP visits, neurology visits, and imaging scans).

Results:

Across the 591 counties in the Central Appalachian region, the average prevalence of ADRD from 2015– 2018 was 11.8%. ADRD prevalence was modestly higher for Appalachian counties both overall (PR: 1.03; 95% CI: 1.02, 1.04) and after adjustment (PR: 1.02; 95% CI: 1.00, 1.03) compared to non-Appalachian counties. This difference was similar among rural and urban counties ( p = 0.326) but varied by state (p = 0.004).

Conclusions:

The relative variation in ADRD prevalence in the Appalachian region was smaller than hypothesized. The case mixture of the dual eligible population, accuracy of the outcome measurement, and impact of educational attainment in this region may contribute to this observation.
Serial Cerebrospinal Fluid Sampling Reveals Trajectories of Potential Synaptic Biomarkers in Early Stages of Alzheimer’s Disease
Authors: Duits Flora H. , Nilsson Johanna , Zetterberg Henrik , Blennow Kaj , van der Flier Wiesje M. , Teunissen Charlotte E. , Brinkmalm Ann
Published: August 2024

Background: Synaptic dysfunction is closely associated with cognitive function in Alzheimer’s disease (AD), and is present already in an early stage of the disease. Objective: Using serial cerebrospinal fluid (CSF) sampling, we aimed to investigate slopes of CSF synaptic proteins, and their relation with cognition along the AD continuum. Methods: We included subjects with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) (n = 50 amyloid-β+ [A +], n = 50 A–) and 50 patients with AD dementia from the Amsterdam dementia cohort, with CSF at two time points (median[IQR] 2.1[1.4–2.7] years). We analyzed 17 synaptic proteins and neurofilament light (NfL). Using linear mixed models we assessed trajectories of protein levels, and associations with cognitive decline (repeated Mini-Mental State Examination). We used Cox regression models to assess predictive value of protein levels for progression to AD dementia. Results: At baseline most proteins showed increased levels in AD dementia compared to the other groups. In contrast NPTX2 levels were lower in AD dementia. Higher baseline levels of SNAP25, β-syn, and 14-3-3 proteins were associated with faster cognitive decline (St.B[SE] –0.27[0.12] to –0.61[0.12]). Longitudinal analyses showed that SYT1 and NPTX levels decreased over time in AD dementia (st.B[SE] –0.10[0.04] to –0.15[0.05]) and SCD/MCI-A+ (St.B[SE] –0.07[0.03] to –0.12[0.03]), but not in SCD/MCI-A- (pinteraction < 0.05). Increase over time in NfL levels was associated with faster cognitive decline in AD dementia (St.B[SE] –1.75[0.58]), but not in the other groups (pinteraction < 0.05). Conclusions: CSF synaptic proteins showed different slopes over time, suggesting complex synaptic dynamics. High levels of especially SNAP-25 may have value for prediction of cognitive decline in early AD stages, while increase in NfL over time correlates better with cognitive decline in later stages.
Bisecting N-Acetylglucosamine Correlates with Phospho-Tau181 in Subjective Cognitive Decline but not in Control Cases
Authors: Egebäck Arulf Sofia , Ziyue Zhou Robin , Kirsebom Bjørn-Eivind , Jejcic Alenka , Fladby Tormod , Winblad Bengt , Tjernberg Lars , Schedin-Weiss Sophia
Published: August 2024

Background: The N-glycan structure bisecting N-acetylglucosamine (bisecting GlcNAc) is present on several N-glycans that are elevated in Alzheimer’s disease (AD), and previous studies have shown that bisecting GlcNAc levels correlate with total tau and phospho-tau181 in cerebrospinal fluid at early stages of AD. A recent population-based study showed that bisecting GlcNAc correlates with total tau also in blood and that this correlation could predict conversion to dementia. Objective: In this study, we have further investigated how bisecting GlcNAc relates to total tau and phospho-tau 181 in cerebrospinal fluid samples from controls and cases with early cognitive deficits, stratified by amyloid/tau status and gender. Methods: Relative levels of bisecting GlcNAc in cerebrospinal fluid were measured by an enzyme-linked lectin assay in individuals with subjective cognitive decline, mild cognitive impairment and controls from the Norwegian Dementia Disease Initiation cohort. Results: As in our previous study, the correlation between bisecting GlcNAc and total tau or phospho-tau181 was particularly strong in the subjective cognitive decline group. The correlation was observed in amyloid negative and tau negative as well as amyloid positive and tau positive individuals, both in females and in males. Interestingly, among the amyloid negative and tau negative individuals, the correlation was observed in individuals with subjective cognitive decline but not in the controls. Conclusions: Thus, bisecting GlcNAc could be a biomarker for early cognitive decline.
Hyperspectral Retinal Imaging as a Non-Invasive Marker to Determine Brain Amyloid Status
Authors: Poudel Purna , Frost Shaun M. , Eslick Shaun , Sohrabi Hamid R. , Taddei Kevin , Martins Ralph N. , Hone Eugene
Published: August 2024

Background: As an extension of the central nervous system (CNS), the retina shares many similarities with the brain and can manifest signs of various neurological diseases, including Alzheimer’s disease (AD). Objective: To investigate the retinal spectral features and develop a classification model to differentiate individuals with different brain amyloid levels. Methods: Sixty-six participants with varying brain amyloid-β protein levels were non-invasively imaged using a hyperspectral retinal camera in the wavelength range of 450–900 nm in 5 nm steps. Multiple retina features from the central and superior views were selected and analyzed to identify their variability among individuals with different brain amyloid loads. Results: The retinal reflectance spectra in the 450–585 nm wavelengths exhibited a significant difference in individuals with increasing brain amyloid. The retinal features in the superior view showed higher inter-subject variability. A classification model was trained to differentiate individuals with varying amyloid levels using the spectra of extracted retinal features. The performance of the spectral classification model was dependent upon retinal features and showed 0.758–0.879 accuracy, 0.718–0.909 sensitivity, 0.764–0.912 specificity, and 0.745–0.891 area under curve for the right eye. Conclusions: This study highlights the spectral variation of retinal features associated with brain amyloid loads. It also demonstrates the feasibility of the retinal hyperspectral imaging technique as a potential method to identify individuals in the preclinical phase of AD as an inexpensive alternative to brain imaging.
ImageSchemaNet: A knowledge graph for embodied commonsense knowledge
Authors: De Giorgis Stefano , Gangemi Aldo , Gromann Dagmar
Published: August 2024

Commonsense knowledge is a broad and challenging area of research which investigates our understanding of the world as well as human assumptions about reality. Deriving directly from the subjective perception of the external world, it is intrinsically intertwined with embodied cognition. Commonsense reasoning is linked to human sense-making, pattern recognition and knowledge framing abilities. This work presents a new resource that formalizes the cognitive theory of image schemas. Image schemas are dynamic conceptual building blocks originating from our sensorimotor interactions with the physical world, and enable our sense-making cognitive activity to assign coherence and structure to entities, events and situations we experience everyday. ImageSchemaNet is an ontology that aligns pre-existing resources, such as FrameNet, VerbNet, WordNet and MetaNet from the Framester hub, to image schema theory. This article describes an empirical application of ImageSchemaNet, combined with semantic parsers, on the task of annotating natural language sentences with image schemas.
How time pressure affects promotive and prohibitive voice of emergency nurse: A cross-sectional study
Authors: Huang Huaqian , Li Fuda , Huangfu Yaojia
Published: August 2024

BACKGROUND: As a developing country, the number of emergency nurses in China is not growing nearly as rapidly as the number of patients, which puts a great deal of stress on emergency nurses’ working hours and may thus impede care quality and patient safety. OBJECTIVE: This study aims to investigate the relationship between time pressure and voice behavior and to explore whether temporal leadership acts as a moderator in the relationship between time pressure and voice behavior. METHODS: Data were collected using scales that have been published in authoritative foreign journals and translated and validated by Chinese scholars. To examine the results more accurately, this paper used the partial least squares (PLS) approach to analyze the research model and verify the research hypothesis. RESULTS: The results of the path analysis and hypothesis testing showed that challenge time pressure and hindrance time pressure both positively and significantly influenced prohibitive voice and promotive voice, while the moderating effect of temporal leadership on the relationship between time pressure and voice behavior was not significant. CONCLUSIONS: Our study revealed that challenge time pressure positively influences emergency nurses’ promotive voice and motivates them to provide their opinions in a reasonable way, while hindrance time pressure motivates emergency nurses’ prohibitive voice, which is not conducive to the improvement of overall organizational functioning and may even damage otherwise good organizational relationships. Furthermore, the study found that the level of temporal leadership does not affect the strength of the relationship between time pressure and voice behavior.
Drive away neck pain: Transformative motor control therapeutic neck exercises and tailored programs redefine posture for automotive workers
Authors: Dinesh Sampathkumar , Kamalakannan Mohanan , Juveria Nazneen Shaik Sarvar Imam , Jilna James Rajeena , Varsha Kathiresan , Yuvasri Shankar , Hariharan Jegadeesan
Published: August 2024

BACKGROUND: Neck discomfort, arising from strained muscles, poor posture, accidents, or underlying medical conditions, significantly impacts daily activities and overall well-being, presenting a substantial healthcare challenge. OBJECTIVE: This study aims to evaluate the efficacy of motor control therapeutic neck exercise and a Structured Exercise Program on neck pain and posture among automobile industrial workers. METHODS: Using a lottery technique, 106 participants aged 20 to 45 were selected from the vicinity of Chennai’s auto industries based on predetermined eligibility and exclusion criteria. Subsequently, participants were randomly assigned to either the motor control therapeutic neck exercise group or the structured exercise program group, each comprising 53 individuals. Participants received a comprehensive overview of the study and respective interventions, and their informed consent was obtained. Demographic details, Neck Injury and Disability scores, and Assessment of Postural and Ergonomic Characteristics data were then collected. RESULTS: Statistical analysis revealed a significant difference between the groups, with the Motor Control Therapeutic Neck Exercise group demonstrating superior outcomes in reducing pain and improving posture, with p-values less than 0.001. CONCLUSIONS: This study highlights the efficacy of Motor Control Therapeutic Neck Exercise over Structured Exercise in improving neck pain and posture among automobile industrial workers. These findings contribute valuable insights for the development of targeted interventions in occupational health settings.
Анализ рынка производителей и собственников
бытовых счетчиков воды
Authors: Паньков Андрей Николаевич , Паньков Андрей Николаевич , Копылова Елена Васильевна , Копылова Елена Васильевна , Шуткова Дарья Сергеевна , Шуткова Дарья Сергеевна
Published: August 2024

Цель данного аналитического обзора заключается в исследовании широко применяемых бытовых (квартирных, индивидуальных) счетчиков воды в качестве средств измерений. Произведен анализ рынка поверки бытовых счетчиков воды, оценена динамика добавления новых типов водосчетчиков в реестр «Утвержденные типы средств измерений» Федерального информационного фонда по обеспечению единства измерений ФГИС «АРШИН» 1. Исследованы страны и ведущие производители бытовых счетчиков воды, включая импортные и отечественные компании, также оценена необходимость замещения импортных водосчетчиков. Составлен список ведущих произво-
дителей бытовых счетчиков воды на основе данных о количестве поверок и выпускаемых средствах измерений, проведен анализ и классификация владельцев счетчиков воды. Рассмотрены наиболее популярные модели водосчетчиков в России и составлен их рейтинг.
Multilevel switching voltage modeling and PWM control strategies for dual two-level converters with open-end winding configuration
Authors:   Faculty of Electronics and Electrical Engineering, Ho Chi Minh City University of Technology, Pham Khoa Dang , Nguyen Nho Van ,   Faculty of Electronics and Electrical Engineering, Ho Chi Minh City University of Technology
Published: August 2024

Dual Two-level converters with Open-end Winding configuration (DTC-OEWs) feature several advantages over Three-level Neutral Point Clamped converters (3L-NPCs), such as even power loss distribution, no requirement of DC-link voltage balancing, fewer number of switching devices, a great number of redundant switching states. However, Pulse-width modulation strategies (PWMs) applied in Dual Two-level converters with Open-end Winding configuration (DTC-OEWs) involve complex and counter-intuitive time-shifting offset for pulse generation whereas the PWM schemes of the traditional multilevel converters, such as the carrier-based Pulse-width modulation (PWM) strategies are simple. And this renders the Pulse-width modulation (PWM) control in DTC-OEWs complex in comparison to that of the traditional multilevel converters. Therefore, multilevel switching voltage models (ML-SVMs) of the Dual Two-level converters with Open-end Winding configuration (DTC-OEWs) with isolated DC-link sources are proposed in this article, thereby enabling the Dual Two-level converters with Open-end Winding configuration (DTC-OEWs) with isolated DC sources, the three-level Neutral Point Clamped converters (3L-NPCs) and the Three-level Cascaded H-bridge converters (3L-CHBs) to be regarded as a single multilevel-converter entity. Thus, it allows a rich pool of simple and intuitive PWM strategies derived for the 3L-NPCs and the 3L-CHBs to be applied directly to the Dual Two-level converters with Open-end Winding configuration (DTC-OEWs) without any modification. Several Pulse-width modulation (PWM) strategies, which are previously utilized for the Three-level Neutral Point Clamped converters (3L-NPCs) and the Three-level Cascaded H-bridge converters (3L-CHBs), are applied to the Dual Two-level converters with Open-end Winding configuration (DTC-OEWs) by using the multilevel switching voltage models (ML-SVMs). Simulation results of several PWM strategies, including the line voltages, phase currents, and the common-mode voltages from the three-level Neutral-Point Clamped converter (3L-NPC) and the Dual Two-level converter with Open-ends Winding configuration (DTC-OEW) bear a complete resemblance, thereby indicating the correctness of the multilevel switching voltage models.
Bekämpfung von Altersdiskriminierung im privatrechtlichen Arbeitsverhältnis
Authors: Schwestermann Mark-Anthony
Published: August 2024

Die vorliegende Arbeit stellt sich der Frage, welche rechtlichen Massnahmen auf den Gebieten des privaten Arbeitsrechts und des Sozialversicherungsrechts ergriffen werden sollten, um Altersdiskriminierung - insbesondere gegenüber älteren Personen im Erwerbsleben - zu bekämpfen. Zu diesem Zweck setzt sich der Autor zunächst mit dem Phänomen «Ageism» und seinen Ursachen auseinander. Gestützt auf daraus gewonnenen Erkenntnissen wird ein Antidiskriminierungsmodell entwickelt, das Diskriminierungsverbote sowie Massnahmen der Prävention und Inklusion vorsieht. Ausgehend von diesem Modell werden das Schweizer Antidiskriminierungsrecht analysiert und Teile davon mit relevantem EU-Recht verglichen. Schliesslich werden diverse rechtliche Massnahmen formuliert.
Reform of capital adequacy regulation in the world Islamic banking market
Authors: Penikas H. I. , Stefanenko V. Y.
Published: August 2024

In 2023, one of the main standards for regulating Islamic banks in the world celebrated its 10th anniversary. It is difficult to find works in the academic literature discussing the reaction from the said regulation. We fill this gap and answer the research question of how the market responded to the introduction of the standard in the world. Having essentially the data of a quasi-experiment, we divide the sample into conventional (control group) and Islamic (pilot group) banks and estimate the effect of the intervention using the difference-in-differences method. Islamic banks have been known in the world practice as banks with a larger capital reserve than conventional ones. Interestingly, despite this fact, according to the results of the study, investors reacted positively to the additional capital correction.
REPORT ON THE ULTIMATE VIEW OF LEGAL COMMUNICATION IN THE SPACE LEGAL SECTOR
Authors: Owczarek Sonia
Published: August 2024

Author describes her academic and professional engagements in space law
illuminating the path towards understanding and collaboration in unusual students ventures.
TAX AUDIT AND PREPARATION FOR THE TAX AUDIT: MAINTAINING THE FINANCIAL STABILITY OF THE ORGANIZATION
Authors: Grylitska Anzhela
Published: August 2024

Abstract. The study highlights the strategies and methods needed to effectively pass tax audits and ensure the sustainability of a company's finances in the face of constant changes in tax legislation. The paper examines the concept of tax audit and the importance of readiness for tax audit to ensure financial stability. Particular attention is paid to strategies for preparing for tax audits, including improving internal control systems and auditing tax obligations. The optimization of taxation is studied as a key aspect of ensuring financial sustainability. The work includes the analysis of effective strategies for reducing tax costs and minimizing the risks of tax audits. This work is of practical importance for organizations seeking to avoid financial difficulties related to tax aspects. The recommendations provided in the study can serve as a guide for management and finance professionals when planning and implementing tax management strategies. This work is important for organizations of all sizes and industries, as tax is a key element of financial management and the right preparation can make a significant difference to their financial sustainability.