bluuebunny/crossref_metadata_2025 huggingface dataset:
Key proteins as potential effective biomarkers under Intraoperative Radiotherapy (IORT) in tumor bed of Breast Cancer patients
Authors: shahani minoo , Shakeri Jafar , Tafti Ali , Akbari Mohammad Esmaeil
Published: March 2020

Background Radiotherapy (RT) is recommended to all patients undergoing Breast Conserving Surgery (BCS). Two strategies can be applied to irradiation, External Beam RT (EBRT) in addition, Intraoperative Radiation Therapy (IORT). The aim of this study was to introduce a protein biomarker panel related to molecular function under IORT. Methods Six Breast Cancer (BC) patients as a pilot study were treated by 12 Gy (Boost dose) and 21 Gy (Radical dose). Samples tissue included Margin before IORT (MB), and Margin 24 hours After IORT (MA24 h). Isobaric Tag for Relative and Absolute Quantitation (iTRAQ) was performed to study proteomic of IORT-treated tumor bed. Results We classified 110 differentially expressed proteins (DEPs) as a protein biomarker panel by mapping the annotated coding region sequences to the reference canonical pathways in the KEGG database. Conclusion Our findings indicate that the DEPs may be key proteins in IORT-treated tumor bed and may serve as potential Effective biomarkers under IORT.
Gene Expression Profile Associated With Neural Tube Defects Among Infants Attending Muhimbili National Hospital And Muhimbili Orthopaedic Institute In Tanzania
Authors: Sadallah Mariam , Assenga Evelyne Neema , Pallangyo Charles , Manji Karim
Published: March 2020

Background: Neural tube defects (NTDs) are severe congenital anomalies of the central nervous system. The specific cause is not known, though several factors including gene variants involving the folate metabolism have been implicated in the etiology. This study aimed at identifying the gene expression profile of selected genes known to be associated with NTDs among infants attending Muhimbili National Hospital (MNH) and Muhimbili Orthopaedic Institute (MOI).Methodology: We conducted a matched case control study involving infants who were attending MNH and MOI during 6 months of the study period. Each case was matched with two controls by gestational age, sex and birth weight. Whole blood samples were collected from all study participants for genetic analysis. Total RNA was isolated using Qiagen RNA blood mini kit, and reversed transcribed into complementary DNA (cDNA) using Super Script II Reverse Transcriptase cDNA Synthesis kit. Real-time polymerase chain reaction was performed on extracted cDNA by a Light Thermal Cycler 480 machine using specific primers for studied genes to determine their expression levels. Results were analysed by GraphPad Prism 5Software, using Student t-test, and Bonferroni post hoc statistical tests. A p value of < 0.05 was considered to be statistically significant.Results: The study recruited 50 cases and 100 controls. Among eight studied genes, we found significantly low expression of Methylenetetrahydrofolate reductase [MTHFR] gene among cases than controls (p=0.006). Expression of others genes were having variations and expressed at very low levels in both cases and controls.Conclusion: A low expression level of MTHFR gene was a significant risk factor for the occurrence of NTDs amongst infants attending MNH and MOI.Recommendation: We recommend gene expression analysis to be done on mothers of infants with NTDs to identify those at risk; and further mutational analysis to be done to enhance genetic counseling and therefore to prevent recurrence of NTDs.
Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China
Authors: Wu Joseph T , Leung Kathy , Bushman Mary , Kishore Nishant , Niehus Rene , de Salazar Pablo M , Cowling Benjamin J , Lipsitch Marc , Leung Gabriel M
Published: March 2020

As of February 13, 2020, there have been 59,863 laboratory-confirmed cases of COVID-19 infections in mainland China, including 1,367 deaths. A key public health priority during the emergence of a novel pathogen is estimating clinical severity. Here we estimated the symptomatic case-fatality risk (sCFR; the probability of dying from the infection after developing symptoms) of COVID-19 in Wuhan using public and published information. We estimated that sCFR was 0.5% (0.1%-1.3%), 0.5% (0.2%-1.1%) and 2.7% (1.5%-4.7%) for those aged 15-44, 45-64 and >64 years. The overall sCFR among those aged ≥15 years was 1.4% (0.8%-2.0%). Authors Joseph T Wu and Kathy Leung contributed equally to this work
Longer Photoperiods with Adaptive Lighting Control Can Improve Growth of Greenhouse-grown ‘Little Gem’ Lettuce (Lactuca sativa)
Authors: Weaver Geoffrey , van Iersel Marc W.
Published: March 2020

Supplemental lighting can improve the growth of greenhouse crops, but the electricity required for supplemental lighting can be a significant expense for greenhouse growers. Lighting control strategies that use the dimmability of light-emitting diodes (LEDs) have the potential to decrease this cost. In our experiments, we tested the hypothesis that providing ‘Little Gem’ lettuce (Lactuca sativa) plants with the same daily amount of light, spread out over a longer photoperiod and at lower average photosynthetic photon flux densities (PPFDs), would improve growth because light is used more efficiently to drive photosynthesis at lower PPFDs. We conducted two greenhouse experiments wherein supplemental light was provided to reach a minimum daily light integral (DLI) of 17 mol·m−2·d−1 with a 12, 15, 18, or 21-hour photoperiod using adaptive lighting control of LED lights. As the photoperiod for supplemental lighting was increased and supplemental light was provided at lower average PPFDs, plant dry weight increased. Conversion efficiency, the estimated increase in dry weight per Joule expended on supplemental lighting, increased as the photoperiod was extended from 12 to 21 hours. Leaf size and chlorophyll content index increased with longer photoperiods. The number of plants with symptoms of tipburn, including apical and marginal necrosis, also increased as the photoperiod was extended. These results demonstrate that adaptive lighting control can be used to increase the growth of ‘Little Gem’ lettuce and the energy use efficiency of supplemental lighting by providing supplemental light at relatively low PPFDs.
ALİ HAYDAR EFENDİ’NİN ALTIN, GÜMÜŞ GİBİ MADENLERLE SÂBİT OLAN BORÇLARIN EVRÂK-I NAKDİYYE İLE ÖDENEMEYECEĞİNE İLİŞKİN HUKUKÎ GÖRÜŞLERİ
Authors: KARAKOÇ İrem
Published: March 2020

Çalışmamızın konusu, Osmanlı hukukçusu ve Adliye Nâzırı Ali Haydar Efendi’nin “Risâletü fî Kazâi’d-Düyûn ve İktizâühû” adlı eserinin “Deynin Sûret-i İdaresi ve İcârenin Ehad-i Âkideynin Vefatı Hâlinde Adem-i İnfisâhı Hakkındaki Ahkâm” başlıklı makalesinin Birinci Risâle’si olan “Maʽdenî Altınla Sâbit Olan Düyûnun Maʽdenî Altın İ’tâsıyla Te’diyesi Lâzım Geleceğine Dâirdir” başlıklı kısmında yer verdiği görüşleridir. Yazar, 1331 ve 1332’de çıkarılan kanunlarla, borçların ödenmesinde evrâk-ı nakdiyyenin Osmanlı mâlî sisteminde zorunlu ödeme aracı kabul edilmesinin sonuçlarını ele almıştır. Kanun’dan önce altın üzerinden akdedilen borç sözleşmelerinin ifası, düzenlemelerden sonra kâğıt parayla yapılmak zorundaydı. Kanunlardan biri, 31 Ekim 1915 (18 Teşrînievvel 1331) tarihli “Evrâk-ı Nakdiyye Kanunu”; diğeri, 8 Nisan 1916 (26 Mart 1332/5 Cemâziyelâhir 1334) tarihli “Tevhîd-i Meskûkât Kanunu”dur. Ancak borç sözleşmelerinde borcun konusu altın veya gümüş gibi kendi değeri olan madenlerse, alacaklı için bunun aynen ödenmesi önemlidir. Borçlu ise, kâğıt parayla ifayı tercih eder. “Evrâk-ı Nakdiyye Kanunu”ndan önce kurulan fakat Kanun’dan sonra ödenecek olan borçlarda Ali Haydar Efendi, ortaya çıkan karışıklığa çözüm önermiştir. Sorun temelde, 1331 ve 1332 tarihli düzenlemelerin yürürlüğe girmesinden önce yapılan borç sözleşmelerinde ifası gereken borcun altın mı, yoksa evrâk-ı nakdiyye olarak mı ödeneceğidir. Risâlenin giriş kısmında 1331 (1915-1916) ve 1335 (1919) olmak üzere iki tarih vardır.
The impact of strategic human resources planning on the organizational performance of public shareholding companies in Jordan
Authors: Al-Qudah Shaker , Mishael Obeidat Abdallah , Shrouf Hosam , A. Abusweilem Mohammed
Published: March 2020

Performance management (PM) is a common practice used by organizations to assess and manage employees’ work. Much of PM research is closely related to management practices. Corporations in the public and nonprofit sector continuously develop PM programs to ensure the sustainability of their organizations. The study aims to analyze the impact of strategic human resources planning on the organizational performance of Jordanian public shareholding companies for senior management and functional unit managers (human resources, marketing, finance, and accounting). The researchers surveyed all the public shareholding companies registered with the Jordan Securities Commission (JSC) in 2019, wherein they found that only 60 companies applied strategic planning and human resources planning (HRP) together. Two hundred and twenty questionnaires were distributed in 52 companies surveyed, and 203 were adopted for statistical analysis. Several statistical methods were used, most notably the multiple regression analysis. The researchers found out a statistically significant impact of the strategic human resources planning (integration of HRP and strategic planning; strategic participation) on organizational performance. The results showed that adopting the strategic HRP dimensions leads to an increase in an organization’s overall productivity, employee satisfaction and reputation, as well as reduced operating costs. HR managers must understand the effectiveness of strategically designed HR practices across functions.
1-Benzil-3-Metilimidazolyum Hekzaflorofosfat’ın Asidik Ortamda C1010 Çeliğin Korozyonuna Etkisi
Authors: SIĞIRCIK Gökmen
Published: March 2020

Bu çalışmada, C1010 çeliğin 1 M HCl çözeltisindeki korozyonuna 1-benzil-3-metilimidazolyum hekzaflorofosfat’ın inhibisyon etkinliği çalışılmıştır. Elektrokimyasal impedans spektroskopi (EIS) ve potansiyodinamik polarizasyon teknikleri kullanılmıştır. Potansiyodinamik polarizasyon sonuçları, anodik ve katodik akım yoğunluklarının inhibitör derişiminin artması ile azaldığını göstermiştir. EIS ölçümlerinden ise artan sıcaklıklarda dahi inhibisyon etkinliklerinin halen yüksek olduğu belirlenmiştir. İnhibitörün metal üzerindeki adsorpsiyon davranışı, Langmiur adsorpsiyon izotermine uymaktadır. Elde edilen tüm sonuçlar, kullanılan inhibitörün C1010 çeliğin asidik ortamdaki korozyonu üzerine %83,5 inhibisyon etkinliğine sahip olduğu göstermektedir.
Sustainable economic level of leakage in Norway and Sweden – manual of practice
Authors: Malm A. , Svensson G. , Røstum J. , Axell L.
Published: March 2020

Awareness of water's value, high water losses, occasional water shortages and increased costs arising from new treatment requirements has increased focus on reducing water losses. For water loss management, SELL (sustainable economic level of leakage), can be used. SELL includes not only the long-term utility costs and benefits, but also external social and environmental leakage costs, including traffic disruption during pipe repair and replacement work, carbon footprints and health risk effects from leaking pipes with inadequate pressure. The aim of the project was to adapt SELL to Norwegian and Swedish conditions and prepare a calculation model for SELL for use by water utilities. A spreadsheet was developed to calculate water balances and leakage. Another was developed for calculating SELL for the utility. The latter spreadsheet includes research-based default values if no local data are available. An uncertainty analysis was used to show how much input data uncertainty affects the result. The conclusions are that, when all externalities are included and new leak reduction techniques are developed, SELL is lower than expected. The authors believe that the manual will help significantly in fighting water losses, especially for small- and medium- scale water utilities.
Nose to Brain Delivery of Nanocarriers Towards Attenuation of Demented Condition
Authors: Gorain Bapi , Rajeswary Davinaa C. , Pandey Manisha , Kesharwani Prashant , Kumbhar Santosh A. , Choudhury Hira
Published: March 2020

Increasing incidence of demented patients around the globe with limited FDA approved conventional
therapies requires pronounced research attention for the management of the demented conditions in the growing
elderly population in the developing world. Dementia of Alzheimer’s type is a neurodegenerative disorder, where
conventional therapies are available for symptomatic treatment of the disease but possess several peripheral toxicities
due to lack of brain targeting. Nanotechnology based formulations via intranasal (IN) routes of administration
have shown to improve therapeutic efficacy of several therapeutics via circumventing blood-brain barrier and
limited peripheral exposure. Instead of numerous research on polymeric and lipid-based nanocarriers in the improvement
of therapeutic chemicals and peptides in preclinical research, a step towards clinical studies still requires
wide-ranging data on safety and efficacy. This review has focused on current approaches of nanocarrierbased
therapies on Alzheimer’s disease (AD) via the IN route for polymeric and lipid-based nanocarriers for the
improvement of therapeutic efficacy and safety. Moreover, the clinical application of IN nanocarrier-based delivery
of therapeutics to the brain needs a long run; however, proper attention towards AD therapy via this platform
could bring a new era for the AD patients.
Optimization and Characterization of Aqueous Micellar Formulations for Ocular Delivery of an Antifungal Drug, Posaconazole
Authors: Durgun Meltem E. , Kahraman Emine , Güngör Sevgi , Özsoy Yıldız
Published: March 2020

Background:

Topical therapy is preferred for the management of ocular fungal infections due to its
superiorities which include overcoming potential systemic side effects risk of drugs, and targeting of drugs to the
site of disease. However, the optimization of effective ocular formulations has always been a major challenge due
to restrictions of ocular barriers and physiological conditions. Posaconazole, an antifungal and highly lipophilic
agent with broad-spectrum, has been used topically as off-label in the treatment of ocular fungal infections due to
its highly lipophilic character. Micellar carriers have the potential to improve the solubility of lipophilic drugs
and, overcome ocular barriers.

Objective:

In the current study, it was aimed optimization of posaconazole loaded micellar formulations to improve
aqueous solubility of posaconazole and to characterize the formulations and to investigate the physical
stability of these formulations at room temperature (25°C, 60% RH), and accelerated stability (40°C, 75% RH)
conditions.

Method:

Micelles were prepared using a thin-film hydration method. Pre-formulation studies were firstly performed
to optimize polymer/surfactant type and to determine their concentration in the formulations. Then, particle
size, size distribution, and zeta potential of the micellar formulations were measured by ZetaSizer Nano-ZS.
The drug encapsulation efficiency of the micelles was quantified by HPLC. The morphology of the micelles was
depicted by AFM. The stability of optimized micelles was evaluated in terms of particle size, size distribution,
zeta potential, drug amount and pH for 180 days. In vitro release studies were performed using Franz diffusion
cells.

Results:

Pre-formulation studies indicated that single D-ɑ-tocopheryl polyethylene glycol succinate (TPGS), a
combination of it and Pluronic F127/Pluronic F68 are capable of formation of posaconazole loaded micelles at
specific concentrations. Optimized micelles with high encapsulation efficiency were less than 20 nm, approximately
neutral, stable, and in aspherical shape. Additionally, in vitro release data showed that the release of posaconazole
from the micelles was higher than that of suspension.

Conclusion:

The results revealed that the optimized micellar formulation of posaconazole offers a potential approach
for topical ocular administration.
An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review
Authors: Bosebabu Bellamkonda , Cheruku Sri Pragnya , Chamallamudi Mallikarjuna Rao , Nampoothiri Madhavan , Shenoy Rekha R. , Nandakumar Krishnadas , Parihar Vipan K. , Kumar Nitesh
Published: March 2020

Sesame (Sesamum indicum L.) seeds have been authenticated for its medicinal value in both
Chinese and Indian systems of medicine. Its numerous potential nutritional benefits are attributed to its
main bioactive constituents, sesamol. As a result of those studies, several molecular mechanisms are
emerging describing the pleiotropic biological effects of sesamol. This review summarized the most
interesting in vitro and in vivo studies on the biological effects of sesamol. The present work summarises
data available from Pubmed and Scopus database. Several molecular mechanisms have been elucidated
describing the pleiotropic biological effects of sesamol. Its major therapeutic effects have been
elicited in managing oxidative and inflammatory conditions, metabolic syndrome and mood disorders.
Further, compelling evidence reflected the ability of sesamol in inhibiting proliferation of the inflammatory
cell, prevention of invasion and angiogenesis via affecting multiple molecular targets and
downstream mechanisms. Sesamol is a safe, non‐toxic chemical that mediates anti‐inflammatory
effects by down‐regulating the transcription of inflammatory markers such as cytokines, redox status,
protein kinases, and enzymes that promote inflammation. In addition, sesamol also induces apoptosis
in cancer cells via mitochondrial and receptor‐mediated pathways, as well as activation of caspase cascades.
In the present review, several pharmacological effects of sesamol are summarised namely, antioxidant,
anti-cancer, neuroprotective, cardioprotective, anti-inflammatory, hypolipidemic, radioprotective,
anti-aging, anti-ulcer, anti-dementia, anti-depressant, antiplatelet, anticonvulsant, anti-anxiolytic,
wound healing, cosmetic (skin whitening), anti-microbial, matrix metalloproteinase (MMPs) inhibition,
hepatoprotective activity and other biological effects. Here we have summarized the proposed
mechanism behind these pharmacological effects.
The Role of the Cannabinoid System in Opioid Analgesia and Tolerance
Authors: Ozdemir Ercan
Published: March 2020

Opioid receptor agonist drugs, such as morphine, are very effective for treating chronic and severe pain; but, tolerance can develop with long-term use. Although there is a lot of information about the pathophysiological mechanisms of opioid tolerance, it is still not fully clarified. Suggested mechanisms for opioid tolerance include opioid receptor desensitisation, reduction of sensitivity G-proteins, activation of Mitogen-Activated Protein Kinase (MAPK), altered intracellular signaling pathway including nitric oxide, and activation of mammalian Target of Rapamycin (mTOR). One way to reduce opioid tolerance and increase the analgesic potential is to use low doses. Combination of cannabinoids with opioids has been shown to manifest the reduction of the opioid dose. Experimental studies revealed an interaction of the endocannabinoid system and opioid antinociception. Cannabinoid and opioid receptor systems use common pathways in the formation of analgesic effect and demonstrate their activity via G Protein Coupled Receptors (GPCR). Cannabinoid drugs modulate opioid analgesic activity at a number of distinct levels within the cell, ranging from direct receptor associations to post-receptor interactions through shared signal transduction pathways. This review summarizes the data indicating that with combining cannabinoids and opioids drugs may be able to produce long-term analgesic effects, while preventing the opioid analgesic tolerance.
Exergames for Children and Adolescents with Autism Spectrum Disorder: An Overview
Authors: Lima João L. , Axt Glaciane , Teixeira Diogo S. , Monteiro Diogo , Cid Luis , Yamamoto Tetsuya , Murillo-Rodriguez Eric , Machado Sergio
Published: March 2020

Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental disorder associated with various etiologies and characterized by deficits in social interaction, emotional reciprocity, communication, motor skills and cognitive functions. Studies have proposed that limited levels of physical activity and late motor skills and fitness, particularly in children and adolescents with ASD, may accentuate social and emotional deficits. In view of this, exergames, which are active video-games, can be considered a low-cost and safe type of exercise for children and adolescents with ASD, since they are more enjoyable than ordinary physical activities, influencing on treatment adherence. Thus, our study aims to evidence the effects of exergames on physical fitness, cognitive functions, and repetitive behaviors in children and adolescents with ASD. Despite the small number of studies investigating the effects of exergames as new strategy in children and adolescents with ASD, results suggest exergames as potential tool for the treatment of children and adolescents with ASD for improvement in physical fitness, cognitive functions and repetitive behavior. Our review pointed towards the importance of exergames for children and adolescents with ASD. Despite few studies conducted about this issue, we can consider exergames a potential tool to increase physical fitness, cognitive functions and to decrease repetitive behavior in children and adolescents with ASD. Moreover, health professionals should be careful when attempting to help this population, because the current literature is unclear yet about the improvement of ASD features through exergames.
The Opportunities and Challenges of Preformed Particle Gel in Enhanced Oil Recovery
Authors: Akbar Imran , Hongtao Zhou
Published: March 2020

Enhanced Oil Recovery (EOR), is a technique that has been used to recover the remaining oil from the reservoirs after primary and secondary recovery methods. Some reservoirs are very complex and require advanced EOR techniques that containing new materials and additives in order to produce maximum oil in economic and environmentally friendly manners. Because of EOR techniques, in this work previous and current challenges have been discussed, and suggested some future opportunities. This work comprises the key factors, such as; transport of Preformed Particle Gels (PPGs), Surface wettability and conformance control that affect the efficiency of PPGs. The conduits, fractures, fracture-like features and high permeability streaks are the big challenges for EOR, as they may cause early water breakthrough and undesirable water channeling. Hence, the use of PPGs is one of the exclusive commercial gel inventions, which not only increases the oil production but also decreases the water cut during the oil production. Moreover, different studies regarding PPG, surfactants, and Silica nanoparticle applications, such as the effect of salinity, particle size, swelling ratio, gel strength, wettability, and adsorption were also discussed. Future work is required in order to overcome the conformance problems and increase the oil recovery.
Technology-Enabled Self-Management of Chronic Obstructive Pulmonary Disease With or Without Asynchronous Remote Monitoring: Randomized Controlled Trial (Preprint)
Authors: Stamenova Vess , Liang Kyle , Yang Rebecca , Engel Katrina , van Lieshout Florence , Lalingo Elizabeth , Cheung Angelica , Erwood Adam , Radina Maria , Greenwald Allen , Agarwal Payal , Sidhu Aman , Bhatia R Sacha , Shaw James , Shafai Roshan , Bhattacharyya Onil
Published: March 2020

BACKGROUND

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and leads to frequent hospital admissions and emergency department (ED) visits. COPD exacerbations are an important patient outcome, and reducing their frequency would result in significant cost savings. Remote monitoring and self-monitoring could both help patients manage their symptoms and reduce the frequency of exacerbations, but they have different resource implications and have not been directly compared.

OBJECTIVE

This study aims to compare the effectiveness of implementing a technology-enabled self-monitoring program versus a technology-enabled remote monitoring program in patients with COPD compared with a standard care group.

METHODS

We conducted a 3-arm randomized controlled trial evaluating the effectiveness of a remote monitoring and a self-monitoring program relative to standard care. Patients with COPD were recruited from outpatient clinics and a pulmonary rehabilitation program. Patients in both interventions used a Bluetooth-enabled device kit to monitor oxygen saturation, blood pressure, temperature, weight, and symptoms, but only patients in the remote monitoring group were monitored by a respiratory therapist. All patients were assessed at baseline and at 3 and 6 months after program initiation. Outcomes included self-management skills, as measured by the Partners in Health (PIH) Scale; patient symptoms measured with the St George’s Respiratory Questionnaire (SGRQ); and the Bristol COPD Knowledge Questionnaire (BCKQ). Patients were also asked to self-report on health system use, and data on health use were collected from the hospital.

RESULTS

A total of 122 patients participated in the study: 40 in the standard care, 41 in the self-monitoring, and 41 in the remote monitoring groups. Although all 3 groups improved in PIH scores, BCKQ scores, and SGRQ impact scores, there were no significant differences among any of the groups. No effects were observed on the SGRQ activity or symptom scores or on hospitalizations, ED visits, or clinic visits.

CONCLUSIONS

Despite regular use of the technology, patients with COPD assigned to remote monitoring or self-monitoring did not have any improvement in patient outcomes such as self-management skills, knowledge, or symptoms, or in health care use compared with each other or with a standard care group. This may be owing to low health care use at baseline, the lack of structured educational components in the intervention groups, and the lack of integration of the action plan with the technology.

CLINICALTRIAL

ClinicalTrials.gov NCT03741855; https://clinicaltrials.gov/ct2/show/ NCT03741855
A Smartphone-Based Technique to Detect Dynamic User Preferences for Tailoring Behavioral Interventions: Observational Utility Study of Ecological Daily Needs Assessment (Preprint)
Authors: Nicol Ginger E , Ricchio Amanda R , Metts Christopher L , Yingling Michael D , Ramsey Alex T , Schweiger Julia A , Miller J Philip , Lenze Eric J
Published: March 2020

BACKGROUND

Mobile health apps are promising vehicles for delivering scalable health behavior change interventions to populations that are otherwise difficult to reach and engage, such as young adults with psychiatric conditions. To improve uptake and sustain consumer engagement, mobile health interventions need to be responsive to individuals’ needs and preferences, which may change over time. We previously created an ecological daily needs assessment to capture microprocesses influencing user needs and preferences for mobile health treatment adaptation.

OBJECTIVE

The objective of our study was to test the utility of a needs assessment anchored within a mobile app to capture individualized, contextually relevant user needs and preferences within the framework of a weight management mobile health app.

METHODS

Participants with an iOS device could download the study app via the study website or links from social media. In this fully remote study, we screened, obtained informed consent from, and enrolled participants through the mobile app. The mobile health framework included daily health goal setting and self-monitoring, with up to 6 daily prompts to determine in-the-moment needs and preferences for mobile health–assisted health behavior change.

RESULTS

A total of 24 participants downloaded the app and provided e-consent (22 female; 2 male), with 23 participants responding to at least one prompt over 2 weeks. The mean length of engagement was 5.6 (SD 4.7) days, with a mean of 2.8 (1.1) responses per day. We observed individually dynamic needs and preferences, illustrating daily variability within and between individuals. Qualitative feedback indicated preferences for self-adapting features, simplified self-monitoring, and the ability to personalize app-generated message timing and content.

CONCLUSIONS

The technique provided an individually dynamic and contextually relevant alternative and complement to traditional needs assessment for assessing individually dynamic user needs and preferences during treatment development or adaptation. The results of this utility study suggest the importance of personalization and learning algorithms for sustaining app engagement in young adults with psychiatric conditions. Further study in broader user populations is needed.
Developing a Plan for the Sustainable Implementation of an Electronic Health Intervention (Partner in Balance) to Support Caregivers of People With Dementia: Case Study (Preprint)
Authors: Christie Hannah Liane , Boots Lizzy Mitzy Maria , Peetoom Kirsten , Tange Huibert Johannes , Verhey Frans Rochus Josef , de Vugt Marjolein Elizabeth
Published: March 2020

BACKGROUND

Given the increasing use of digital interventions in health care, understanding how best to implement them is crucial. However, evidence on how to implement new academically developed interventions in complex health care environments is lacking. This case study offers an example of how to develop a theory-based implementation plan for Partner in Balance, an electronic health (eHealth) intervention to support the caregivers of people with dementia.

OBJECTIVE

The specific objectives of this study were to (1) formulate evidence-based implementation strategies, (2) develop a sustainable business model, and (3) integrate these elements into an implementation plan.

METHODS

This case study concerns Partner in Balance, a blended care intervention to support the caregivers of people with dementia, which is effective in improving caregiver self-efficacy, quality of life, and experienced control. The large-scale implementation of Partner in Balance took place in local dementia case-management services, local care homes, dementia support groups, and municipalities. Experiences from real-life pilots (n=22) and qualitative interviews with national stakeholders (n=14) were used to establish an implementation plan consisting of implementation strategies and a business model.

RESULTS

The main finding was the need for a business model to facilitate decision-making from potential client organizations, who need reliable pricing information before they can commit to training coaches and implementing the intervention. Additionally, knowledge of the organizational context and a wider health care system are essential to ensure that the intervention meets the needs of its target users. Based on these findings, the research team formulated implementation strategies targeted at the engagement of organizations and staff, dissemination of the intervention, and facilitation of long-term project management in the future.

CONCLUSIONS

This study offers a theory-based example of implementing an evidence-based eHealth intervention in dementia health care. The findings help fill the knowledge gap on the eHealth implementation context for evidence-based eHealth interventions after the trial phase, and they can be used to inform individuals working to develop and sustainably implement eHealth.
ACTIVE CONSTITUENTS AND BIOLOGICAL ACTIVITY OF METHANOLIC EXTRACT OF FORSSKAOLEA VIRIDIS AERIAL PARTS
Authors: ALY AHMED FATMA , EL-BASSOSSY TAHA A. I.
Published: March 2020

Objective: The objective of this study is to isolate and evaluate the antioxidant, antimicrobial, and antitumor activity of the methanolic constituents of Forsskaolea viridis.

Methods: The isolation and purification of phytochemical constituents were performed in the present study using various chromatographic methods (thin-layer [TLC], preparative paper [PPC], and column chromatography [CC]) where, the structures of isolated compounds were determined using different spectroscopic methods (Mass spectroscopy [Ms], ultraviolet [UV], proton and carbon nuclear magnetic resonance [1H-NMR and 13C-NMR]) and confirmed by data reported in the literature. The biological activity of the methanolic extract was performed as in vitro studies by diffusion agar technique, 2,2-Diphenyl-1-picrylhydrazyl hydrate (DPPH), and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for antimicrobial, antioxidant, and antitumor activity, respectively.

Results: The chemical studies led to the isolation of five flavonoids and two phenolic compounds for the first time from this plant. The methanolic extract exhibited potent antimicrobial activity (13–26 mm) against some of the tested strains while it showed fair antioxidant and cytotoxicity activity.

Conclusion: It can be concluded from the results that the methanolic extract of F. viridis has potential antimicrobial activity while fair antioxidant and antitumor activity.
The effectiveness of a health promotion program using the International Organization for Standardization in Klongyong and Nikhompattana, Thailand
Authors: Terasawa Koji , Maruo Suchinda , Piasue Noppawan , Kalampakorn Surintorn , Utthiya Pinyo , Sasimonthonkul Siriporn , Tabuchi Hisaaki , Akasaki Hisaki , Taki Naoya , Watanabe Toshiaki , Utchiyama Ryoji , Ashida Kazuki , Okuhara Masao
Published: March 2020

Aim: This study aimed to appropriately establish a healthcare program in Thailand that acquired ISO 9001 certification; QC14J0022 (the International Organization for Standardization, ISO) improved problems and inspected the program’s effectiveness. Furthermore, we are making this ISO health promotion widely available in Asian countries and are making an international contribution. Method: We implemented a 9-month health program in Klongyong and a 6-month health program in Nikhompattana, Rayong, Thailand. This program assessed findings from pedometry, anthropometry, physical fitness, and brain function tests. Results: In Klongyong, the average number of walking and exercise steps was 3471.3, and in Nikhompattana, the average number of walking and exercise steps was 4695.5. The pre- and post-health program results in Klongyong showed significant differences in blood pressure, hand grip strength, the 10-meter obstacle walk and the 6-minute walk. In Nikhompattana, there were significant differences in hand grip strength and sit-and-reach flexibility as well as the brain function tests. The pre- and post-health program results in Klongyong and Nikhompattana showed significant differences in the total number of “forgets”. Conclusions: The findings from before and after the health program in Nikhompattana suggest that the increased physical activity during the course of the program may have led to improved brain function results.
EVALUATING THE IMMEDIATE EFFECTS OF DEEP PRESSURE ON CHILDREN DEVELOPMENTAL COORDINATION DISORDER: DEMONSTRATING INDIVIDUAL DIFFERENCES
Authors: SANKAR U GANAPATHY , R MONISHA , VALLABA DOSS CHRISTOPHER AMALRAJ , RM PALANIVEL
Published: March 2020

Objective: However, every occupational therapist used deep pressure for treating children with developmental coordination disorder (DCD). It has been used widely in the therapy aspect, but there is limited research evaluating the immediate effects of deep pressure. The current study aims to evaluate the immediate effects of deep pressure on children with DCD.
Methodology: Pre-test and post-test design was employed; mood and behavior were assessed for 20 children with DCD before and after deep pressure sessions.
Results: Five children responded with positive result on all the domains following deep pressure. Four showed positive result on three out of five domains. Sufficient information was available from eight participants. Three showed beneficial results statistically. A non-parametric technique (Tau-U) was used for the analysis.
Conclusion: Deep pressure has high relevance to clinical practice and appears to be of immediate benefit to this population with DCD.
Democracia entre mujeres: el interés en las reglas, la política institucional y la organización
Authors: Staderini Michi , Gargallo Francesca
Published: March 2020

Democracia entre mujeres: el interés en las reglas, la política institucional y la organización
Cuerpo de mujer
Authors: Schnaith Nelly
Published: March 2020

Cuerpo de mujer
Músculo y veneno
Authors: Sánchez Ferlosio Rafael
Published: March 2020

Músculo y veneno
Chiapas, exterminio de homosexuales, ausencia de derechos humanos
Authors: Brito Alejandro
Published: March 2020

Chiapas, exterminio de homosexuales, ausencia de derechos humanos
Luchadoras urbanas
Authors: Tarrés María Luisa
Published: March 2020

Luchadoras urbanas
Mujeres y política: más allá de las instituciones?
Authors: Ubaldi Garcete Norma
Published: March 2020

Mujeres y política
La Malinche: la lengua en la mano
Authors: Glantz Margo
Published: March 2020

La Malinche: la lengua en la mano
La identidad masculina
Authors: Liendro Eduardo
Published: March 2020

La identidad masculina
Protagonismo y discriminación en el ámbito de la política
Authors: Mariscal Hay Beatriz
Published: March 2020

Protagonismo y discriminación en el ámbito de la política
Índice general
Authors: Feminista Debate
Published: March 2020

Índice general
Índice de autores
Authors: Feminista Debate
Published: March 2020

Índice de autores
Chiapas: el alzamiento de las mujeres indígenas
Authors: Guillén Vicente Rafael Sebastián
Published: March 2020

Chiapas: el alzamiento de las mujeres indígenas
Censura y libertad
Authors: González Rodríguez Sergio
Published: March 2020

Censura y libertad
Teoría literaria feminista: el problema de la representación
Authors: García Irene
Published: March 2020

Teoría literaria feminista: el problema de la representación
Apología: más allá de la desconstrucción / ¿qué es eso de superar?
Authors: Morris Meaghan , Mendiola Salvador
Published: March 2020

Apología: más allá de la desconstrucción / ¿qué es eso de superar?
La negociación para la prevención del sida: entre el deseo y el poder
Authors: Torres Arias María Antonieta , Liguori Ana Luisa
Published: March 2020

La negociación para la prevención del sida: entre el deseo y el poder
Relaciones sexuales
Authors: Moreno Hortensia
Published: March 2020

Relaciones sexuales
Valores sexuales en la era del sida
Authors: Weeks Jeffrey , Vericat Isabel
Published: March 2020

Valores sexuales en la era del sida
La Malinche: del don al contrato sexual
Authors: Franco Jean , Bernal Gloria Elena
Published: March 2020

La Malinche: del don al contrato sexual
Inciarte y el machismo galante
Authors: Olivares Cecilia
Published: March 2020

Inciarte y el machismo galante
La historia previa a Pekín
Authors: Pellicer Olga
Published: March 2020

La historia previa a Pekín
Declaración de la IV Conferencia Mundial sobre la mujer en Pekín
Authors: Unidas Naciones
Published: March 2020

Declaración de la IV Conferencia Mundial sobre la mujer en Pekín
El sujeto inaudito: breve diálogo sobre la diferencia sexual
Authors: Bocchetti Alessandra , Sarasini Bia
Published: March 2020

El sujeto inaudito: breve diálogo sobre la diferencia sexual
¿Es el feminismo una teoría política o una ética?
Authors: Valcárcel y Bernaldo de Quirós Amelia
Published: March 2020

¿Es el feminismo una teoría política o una ética?
El financiamiento: el ruido del dinero
Authors: Bedregal Sáez Ximena , Cedillo Rosa , Gargallo di Castel Lentini Celentani Francesca , González Lucero , Hernández Ana María , Jiménez Flores Elsa Patricia , Mercado Castro Dora Patricia , Talamante Díaz Cecilia , Tarrés Barraza María Luisa , Lamas Marta
Published: March 2020

El financiamiento: el ruido del dinero
También mi hijo está del otro lado del espejo
Authors: Pimentel Luz Aurora
Published: March 2020

También mi hijo está del otro lado del espejo
¿Quién es la otra?: una crítica feminista postmoderna de la teoría y la práctica de mujer y desarrollo
Authors: Parpart Jane L. , Lauer Mirko
Published: March 2020

¿Quién es la otra?: una crítica feminista postmoderna de la teoría y la práctica de mujer y desarrollo
Feminicidio: Por su condición de tal
Authors: Mendoza Garay Ampelio
Published: March 2020

En el Perú existe un tipo penal de feminicidio como un delito autónomo y basado en género. Tal regulación ha traído consigo debates sobre su regulación, respecto si era necesario prever un tipo penal autónomo, cuando existían ya otros tipos penales que protegían el bien jurídico “vida humana”. Asimismo, respecto a la estructura normativa de este articulado, que señala que comete el delito de feminicidio “el que mata a una mujer por su condición de tal”; por lo que se pretende analizar si la regulación actual del delito de feminicidio es lo más  apropiado para proteger realmente en la realidad social y jurídico a la mujer; para lo cual sea desarrollado en base a jurisprudencias de la corte suprema y cortes inferiores, para finalmente discutir y llegar a conclusiones.
El Internet en la era Trump: aproximación constitucional a una nueva realidad
Authors: Sánchez Barrilao Juan Francisco
Published: March 2020

En este trabajo se analiza, desde el derecho constitucional, el principio de neutralidad de Internet. Dicho principio es garantía de imparcialidad e igual trato en relación con los contenidos, el origen y acceso del tráfico en Internet y la interconectividad entre los distintos sistemas y tecnologías de la red. Se analizará también el impacto que las políticas y la forma de hacer política del presidente Donald Trump podría representar para la red por la revocación de la neutralidad de Internet por parte de la Federal Communications Commission (FCC, por sus siglas en inglés), así como por la expansión de la posverdad. El artículo comienza con una aproximación sobre cómo el derecho constitucional afronta hoy el reto tecnológico de Internet, para luego analizar la neutralidad en su doble dimensión sustantiva y formal (o tecnológica), y concluir con algunas consideraciones acerca de las transformaciones y riesgos que puede generar el nuevo giro de la administración de Trump en la democracia.
Penggunaan Mesin Pemotong Kcrupuk Hemat Energi untuk Mcningkatkan Produksi dan Kwalitas Kerupuk Rambak Singkong
Authors: Mokhtar Ali , Kresno Moch Agus
Published: March 2020

Kebutuhan akan kerupuk rambak sebagai sampingan lauk pauk meningkat pesat, seiring pertumbuhan penduduk. Pesanan kerupuk rambak tiap bulan mencapai 2 ton, Sedangkan UKM UD. KERUPUK ENAK hanya mampu memenuhi 50 sampai 60% dan kebutuhan masyarakat. Produksi kerupuk rambak dengan proses manual dengan menggunakan 6 tenaga manusia hanya mampu memproduksi 40 kg tiap hari sehingga satu bulan hanya mampu memproduksi 1 ton. Produksi dengan menggunakan mesin pemotong dengan 2 orang tenaga manusia, mampu memproduksi 240 kg tiap hari, sehingga tiap bulan mampu memproduksi sampai 6 ton. UD. KERUPUK ENAK berlokasi di Desa Druju No. 1 Kecamatan Sumber Manjing Wetan, Kabupaten Malang dengan jarak dari Universitas Muhammadiyah Malang sekitar 50 km merupakan salah satu industri penghasil kerupuk telah berproduksi sejak tahun 2004. Kegiatan pemotongan kerupuk secara manual hanya mampu memberi penghasilan kotor Rp. 5.000.000,- tiap bulan, sedangkan dengan menggunakan mesin pemotong mampu meningkatkan penghasilkan sampai Rp. 30.000.000,- tiap bulan, sehingga dengan adanya mesin pemotong ini sangat membantu bagi UKM. UD. KERUPUK ENAK.
PENDAMPINGAN KELOMPOK TANI BUDIDAYA IKAN “MINA ENDAH” DESA BANGOAN KECAMATAN KEDUNGWARU KABUPATEN TULUNGAGUNG
Authors: Editor Hany Handajani, S.Pi, M.Si , Hastuti, S.Pi, M.Aqua Sri Dwi , Subekhi, ST.MT Nur , Arifin, S.Pi Tri Makmun
Published: March 2020

Desa Bangoan Kecamatan Kedungwaru Kabupaten Tulungagung memiliki potensi perikanansangat baik, hal ini dibuktikan dengan warga yang berjumlah 85 KK bermata pencahariansebagai petani ikan. Petani ikan Desa Bangoan membudidayakan ikan konsumsi dan ikan hias,produksinya di pasarkan didaerah sekitar dan kota-kota di Jawa Timur. Kendala petani ikan diDesa Bangoan adalah pengadaan pakan, hal ini dikarenakan harga pakan ikan yang terus meningkatsehingga memberatkan petani untuk membeli pakan ikan. Pendampingan bertujuan menyelesaikanpermasalahan petani dalam pengadaan pakan ikan. Petani diberi ketrampilan untuk dapat menbuatpakan sendiri, mulai dari pemilihan bahan pakan, pembuatan formulasi pakan dan pembuatanpakan pelet serta cara penggunaan mesin pembuatan pakan ikan. Hasil yang didapatkan responpetani sangat baik dan petani dapat membuat pakan sendiri sehingga dapat menghemat biayaproduksi pada budidaya ikan.Perlu pelatihan dan pendampingan secara berkelanjutan dalam pembuatan pakan ikan bagipetani ikan di Indonesia sehingga petani tidak tergantung pada pakan pabrikan yang harganyamahal dan petani berpeluang mendapatkan keuntungan lebih besar.
Small satellites in space activities
Authors: Gansvind I.N.
Published: March 2020

Changes in space activities related to the practice of using small satellites are considered. The relatively low cost of development, production and launch in low Earth orbiting are explained due to transformation of small satellites into a mass product, available for using in the educational process, remote sensing, in meteorology, flight-testing new technologies, communication and internet distribution as well as space exploration. Small satellites constellations serve the need for systematic global imagery with minimal interval between observing any area of the Earth. Large constella- tions of satellites with radio-occultation equipment provide high-altitude profiles of atmospheric pressure, temperature and humidity for assimilation in weather models. Small satellites will find applications beyond low earth orbits. It is planned to launch 6U CubeSat Sky Fire in the vicinity of the moon to study its surface with new infrared hardware. The projected orbit for Lunar Orbital Platform Gateway will be checked using CubeSat to meet the design requirements.
Everyday training at Moscow College of Geodesy and Cartography
Authors: Abubakarova D.I.
Published: March 2020

The article is dedicated to the 100th anniversary of Moscow College of Geodesy and Cartography. In recent times, good prospects are opening up to secondary vocational education; hence the requirements to its quality are increasing. The staff of the College is not lagging behind. Our main task is the arrangement of the educational process to implement the federal state educational standards. It is carried out in four departments
¿POR QUÉ QUIERO SER PROFESOR DE EDUCACIÓN FÍSICA? ANÁLISIS DEL CAMBIO DE PERCEPCIÓN DURANTE LA FORMACIÓN UNIVERSITARIA Y LOS PRIMEROS AÑOS DE LA CARRERA DOCENTE
Authors: Hortigüela Alcalá David , González Calvo Gustavo , Pérez-Pueyo Ángel
Published: March 2020

O presente estudo tem dois objetivos: a) analisar a evolução da percepção dos futuros professores de EF do primeiro, quarto ano de carreira e graduados; b) contrastar a realidade profissional do professor de EF com a avaliação dos professores universitários de EF. Dez alunos participaram de um projeto longitudinal de seis anos, dividido em três fases (2012, 2015 e 2017). Oito professores universitários também participaram. Foi utilizada uma abordagem qualitativa com dois instrumentos de recolha de dados e foram estabelecidas três categorias de análise. Os resultados mostraram como, no primeiro ano, os alunos duvidam do que é ser professor na EF, enquanto no quarto ano mostram falta de motivação em relação à possibilidade de se tornar um. Por outro lado, os graduados refletem a incoerência existente entre a formação universitária recebida e a exigência do sistema de acesso ao serviço público, uma questão sobre a qual os professores universitários não concordam.