bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis on Spatial Characteristics of Supply–Demand Relationship of Amenities in Expanding Central Urban Areas—A Case Study of Huai’an, China
Authors: Ren Qilong , Ni Jia , Li Hui , Mao Guangxiong , Hsu Wei-Ling , Yang Jing
Published: July 2022

Supply and demand for amenities in expanding urban areas undergo continuous adjustment. In this study, we explored the relationship between supply of and demand for amenities in expanding urban areas to evaluate the rationality and effectiveness of amenity distribution, improve urban governance, and promote urban accessibility and justice, thereby facilitating sustainable urban development. We selected the central urban area of Huai’an City, China as the research area. We used point-of-interest data, Baidu population heatmap data, and residential housing prices to develop supply and demand indices for amenities and analyze the spatial characteristics of the supply of and demand for amenities in expanding urban areas. The results revealed that (1) the supply–demand relationship in the study area was mainly balanced, followed by relationships in which supply was lower than demand, and the relationships of supply exceeding demand is less, accounting for 68.35%, 26.06%, and 5.59%, respectively. (2) The core of the old urban area and the areas surrounding the old urban area had high supply–demand balance, the transitional and new urban areas had less supply than demand, and the developing urban areas had low supply–demand balance; the supply–demand relationship of amenities followed a clear circular distribution pattern. (3) The Chinese government’s continuous renewal of old urban areas has made the quantitative proportion of supply and demand components be positively correlated with the oldness of urban development, which has enlightening effects on the construction of other cities. Finally, we developed suggestions for adjusting the distribution of amenities in the central urban area of Huai’an to facilitate high-quality development in this area.
Clinical Characteristics, Genetic Findings and Arrhythmic Outcomes of Patients with Catecholaminergic Polymorphic Ventricular Tachycardia from China: A Systematic Review
Authors: Leung Justin , Lee Sharen , Zhou Jiandong , Jeevaratnam Kamalan , Lakhani Ishan , Radford Danny , Coakley-Youngs Emma , Pay Levent , Çinier Göksel , Altinsoy Meltem , Behnoush Amir Hossein , Mahmoudi Elham , Matusik Paweł T. , Bazoukis George , Garcia-Zamora Sebastian , Zeng Shaoying , Chen Ziliang , Xia Yunlong , Liu Tong , Tse Gary
Published: July 2022

Introduction: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited cardiac ion channelopathy. The present study aims to examine the clinical characteristics, genetic basis, and arrhythmic outcomes of CPVT patients from China to elucidate the difference between CPVT patients in Asia and Western countries. Methods: PubMed and Embase were systematically searched for case reports or series reporting on CPVT patients from China until 19 February 2022 using the keyword: “Catecholaminergic Polymorphic Ventricular Tachycardia” or “CPVT”, with the location limited to: “China” or “Hong Kong” or “Macau” in Embase, with no language or publication-type restriction. Articles that did not state a definite diagnosis of CPVT and articles with duplicate cases found in larger cohorts were excluded. All the included publications in this review were critically appraised based on the Joanna Briggs Institute Critical Appraisal Checklist. Clinical characteristics, genetic findings, and the primary outcome of spontaneous ventricular tachycardia/ventricular fibrillation (VT/VF) were analyzed. Results: A total of 58 unique cases from 15 studies (median presentation age: 8 (5.0–11.8) years old) were included. All patients, except one, presented at or before 19 years of age. There were 56 patients (96.6%) who were initially symptomatic. Premature ventricular complexes (PVCs) were present in 44 out of 51 patients (86.3%) and VT in 52 out of 58 patients (89.7%). Genetic tests were performed on 54 patients (93.1%) with a yield of 87%. RyR2, CASQ2, TERCL, and SCN10A mutations were found in 35 (71.4%), 12 (24.5%), 1 (0.02%) patient, and 1 patient (0.02%), respectively. There were 54 patients who were treated with beta-blockers, 8 received flecainide, 5 received amiodarone, 2 received verapamil and 2 received propafenone. Sympathectomy (n = 10), implantable cardioverter-defibrillator implantation (n = 8) and ablation (n = 1) were performed. On follow-up, 13 patients developed VT/VF. Conclusion: This was the first systematic review of CPVT patients from China. Most patients had symptoms on initial presentation, with syncope as the presenting complaint. RyR2 mutation accounts for more than half of the CPVT cases, followed by CASQ2, TERCL and SCN10A mutations.
Epidemiology and Management of Cerebral Venous Thrombosis during the COVID-19 Pandemic
Authors: Novaes Natalia , Sadik Raphaël , Sadik Jean-Claude , Obadia Michaël
Published: July 2022

Cerebral venous thrombosis (CVT) is a rare type of stroke that may cause an intracranial hypertension syndrome as well as focal neurological deficits due to venous infarcts. MRI with venography is the method of choice for diagnosis, and treatment with anticoagulants should be promptly started. CVT incidence has increased in COVID-19-infected patients due to a hypercoagulability state and endothelial inflammation. CVT following COVID-19 vaccination could be related to vaccine-induced immune thrombotic thrombocytopenia (VITT), a rare but severe complication that should be promptly identified because of its high mortality rate. Platelet count, D-dimer and PF4 antibodies should be dosed. Treatment with non-heparin anticoagulants and immunoglobulin could improve recuperation. Development of headache associated with seizures, impaired consciousness or focal signs should raise immediate suspicion of CVT. In patients who received a COVID-19 adenovirus-vector vaccine presenting thromboembolic events, VITT should be suspected and rapidly treated. Nevertheless, vaccination benefits clearly outweigh risks and should be continued.
Sport Activity and Clinical Outcomes after Hip Arthroscopy with Acetabular Microfractures at a Minimum 2-Year Follow-Up: A Matched-Pair Controlled Study
Authors: Loppini Mattia , La Camera Francesco , Gambaro Francesco Manlio , Ruggeri Riccardo , Grappiolo Guido , Della Rocca Federico
Published: July 2022

Background: Acetabular microfractures for cartilage lesions have been shown to be a safe procedure able to improve patient reported outcomes (PROs). Nevertheless, the return to sport activity rate represents a crucial outcome to be investigated in these young athletic patients. Methods: Patients undergoing acetabular microfracture for full chondral acetabular lesions were compared to a 1:1 matched-pair by age and gender control group undergoing hip arthroscopy without microfractures. Clinical assessment was performed with PROs and participation in sports in terms of type and level of activities was evaluated preoperatively and at 2-years follow-up. Results: A total of 62 patients with an average age of 35.1 ± 8.1 (microfracture group) and 36.4 ± 6.3 (control group) were included. In both groups, the average values of PROs significantly increased from preoperatively to the last follow-up. There was no significant difference between the two groups in the number of patients playing at the amateur and elite level preoperatively and at the last follow-up. Conclusions: Microfractures for the management of full-thickness acetabular chondral defect provides good clinical results at a minimum follow-up of two years, which are not inferior to a matched-pair control group. Patients undergoing this procedure are likely able to return at the same level of sport before surgery.
Anti-MDA5 Amyopathic Dermatomyositis—A Diagnostic and Therapeutic Challenge
Authors: Bobirca Anca , Alexandru Cristina , Musetescu Anca Emanuela , Bobirca Florin , Florescu Anca Teodora , Constantin Magdalena , Tebeica Tiberiu , Florescu Alesandra , Isac Sebastian , Bojinca Mihai , Ancuta Ioan
Published: July 2022

Clinically amyopathic Dermatomyositis (CADM) is a rare subtype of idiopathic inflammatory myositis, associated with no muscular manifestations, which is more frequent in Asian women. Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are a recently discovered type of specific autoantibodies associated with myositis. The anti-MDA5 DM was initially described in Japan and later it was discovered that the target antigen was a protein implicated in the innate immune response against viruses, that is encoded by the melanoma differentiation-associated gene 5. Anti-MDA5 DM is characteristically associated with distinguished mucocutaneus and systemic manifestations, including skin ulcerations, palmar papules, arthritis, and interstitial-lung disease. Patients with anti-MDA5 positivity have a high risk of developing rapid progressive interstitial-lung disease (RP-ILD), with a poor outcome. As a result, despite high mortality, diagnosis is often delayed, necessitating increased awareness of this possible condition. Despite a severe course of lung disease and an increased mortality rate, there is currently no standard treatment. Recent insights based on observational studies and case reports support combined therapy with immunosuppressive drugs and corticotherapy, as soon as the symptoms appear. The aim of this paper is to describe anti-MDA5 DM, focusing on the recent literature about the unique clinical manifestations and therapeutic options, starting from a severe clinical case diagnosed in our Rheumatology Department.
An Overview of Biofilm Formation–Combating Strategies and Mechanisms of Action of Antibiofilm Agents
Authors: Asma Syeda Tasmia , Imre Kálmán , Morar Adriana , Herman Viorel , Acaroz Ulas , Mukhtar Hamid , Arslan-Acaroz Damla , Shah Syed Rizwan Ali , Gerlach Robin
Published: July 2022

Biofilm formation on surfaces via microbial colonization causes infections and has become a major health issue globally. The biofilm lifestyle provides resistance to environmental stresses and antimicrobial therapies. Biofilms can cause several chronic conditions, and effective treatment has become a challenge due to increased antimicrobial resistance. Antibiotics available for treating biofilm-associated infections are generally not very effective and require high doses that may cause toxicity in the host. Therefore, it is essential to study and develop efficient anti-biofilm strategies that can significantly reduce the rate of biofilm-associated healthcare problems. In this context, some effective combating strategies with potential anti-biofilm agents, including plant extracts, peptides, enzymes, lantibiotics, chelating agents, biosurfactants, polysaccharides, organic, inorganic, and metal nanoparticles, etc., have been reviewed to overcome biofilm-associated healthcare problems. From their extensive literature survey, it can be concluded that these molecules with considerable structural alterations might be applied to the treatment of biofilm-associated infections, by evaluating their significant delivery to the target site of the host. To design effective anti-biofilm molecules, it must be assured that the minimum inhibitory concentrations of these anti-biofilm compounds can eradicate biofilm-associated infections without causing toxic effects at a significant rate.
On the Effect of Heterophilic Antibodies on Serum Levels of Cardiac Troponins: A Brief Descriptive Review
Authors: Chaulin Aleksey Michailovich
Published: July 2022

Serum levels of cardiac troponins can be increased both with myocardial damage and in the absence of myocardial damage. In the second case, this is due to the influence of false-positive factors, among which heterophilic antibodies play a significant role. Understanding the causes of the formation of heterophilic antibodies, the features and mechanisms of their effect on serum levels of cardiac troponins, is an important condition for interpreting a false-positive result due to the influence of heterophilic antibodies. This brief, descriptive review presents the causes of heterophilic-antibodies formation and discusses their effect on serum levels of cardiac troponins.
A Novel Micromechanics-Model-Based Probabilistic Analysis Method for the Elastic Properties of Unidirectional CFRP Composites
Authors: Shan Meijuan , Zhao Libin , Ye Jinrui
Published: July 2022

Considerable uncertainties in the mechanical properties of composites not only prevent them from having efficient applications but also threaten the safety and reliability of structures. In order to determine the uncertainty in the elastic properties of unidirectional CFRP composites, this paper develops a probabilistic analysis method based on a micromechanics theoretical model and the Monte Carlo simulation. Firstly, four commonly used theoretical models are investigated by calculating the deterministic elastic parameters of three unidirectional CFRP composites, which are compared with experimental outcomes. According to error analyses, the bridging model is the most brilliant one, with errors lower than 6%, which suggests that it can be used in probabilistic analyses. Furthermore, constituent parameters are regarded as normally distributed random variables, and the Monte Carlo simulation was used to obtain samplings based on the statistics of constituent parameters. The predicted probabilistic elastic parameters of the T800/X850 composite coincide with those from experiments, which verified the effectiveness of the developed probabilistic analysis method. According to the probabilistic analysis results, the statistics of the elastic parameters, the correlations between the elastic parameters, and their sensitivity to the constituent’s properties are determined. The moduli E11, E22, and G12 of the T800/X850 composite follow the lognormal distribution, namely, ln(E11)~N[5.15, 0.0282], ln(E22)~N[2.15, 0.0242], and ln(G12)~N[1.48, 0.0382], whereas its Poisson’s ratio, v12, obeys the normal distribution, namely, v12~N(0.33, 0.0122). Additionally, the correlation coefficients between v12 and E11/E22/G12 are small and thus can be ignored, whereas the correlation coefficients between any two of E11, E22, and G12 are larger than 0.5 and should be considered in the reliability analyses of composite structures. The developed probabilistic analysis method based on the bridging model and the Monte Carlo simulation is fast and reliable and can be used to efficiently evaluate the probabilistic properties of the elastic parameters of any unidirectional composite in the reliability design of structures in engineering practice.
Regular Periodic Surface Structures on Indium Tin Oxide Film Efficiently Fabricated by Femtosecond Laser Direct Writing with a Cylindrical Lens
Authors: Chen Long , Yang Jian , Jiang Qilin , Cao Kaiqiang , Liu Jukun , Jia Tianqing , Sun Zhenrong , Xu Hongxing
Published: July 2022

Regular laser-induced periodic surface structures (LIPSS) were efficiently fabricated on indium tin oxide (ITO) films by femtosecond laser direct writing with a cylindrical lens. It was found that randomly distributed nanoparticles and high spatial frequency LIPSSs (HSFL) formed on the surface after a small number of cumulative incident laser pulses per spot, and regular low spatial frequency LIPSSs (LSFL) appeared when more laser pulses accumulated. The mechanism of the transition was studied by real-time absorptance measurement and theoretical simulation. Results show that the interference between incident laser and surface plasmon polaritons (SPPs) excited by random surface scatterers facilitates the formation of prototype LSFLs, which in turn enhances light absorption and SPP excitation following laser pulses. The effects of scanning velocity and laser fluence on LSFL quality were discussed in detail. Moreover, large-area extremely regular LSFL with a diameter of 30 mm were efficiently fabricated on an ITO film by femtosecond laser direct writing with the cylindrical lens. The fabricated LSFLs on the ITO film demonstrate vivid structural color. During LSFL processing, the decrease of ITO film thickness leads to the increase of near-infrared optical transmittance.
Study on Remote Field Eddy Current Testing Technology for Crack-like Defects in Long Truss Structure of Aircraft
Authors: Zhang Lipan , Deng Rui , Ning Ning , Fan Junling , Wang Wentao , Song Kai
Published: July 2022

Detection of hidden defects of aircraft long truss structures (aluminum alloy) is a challenging problem. The shape of the aircraft truss structure is complex, and the crack defects are buried in a large depth. Without the restriction of skin effect, remote field eddy current (RFEC) has great advantages in detecting buried depth defects. In this paper, in order to detect the hidden defects of the aluminum alloy aircraft long truss structure, the remote field eddy current probe is improved from two aspects of magnetic field enhancement and near-field signal suppression using the finite element method. The results show that indirect coupling energy is greatly enhanced when the connected magnetic circuit is added to the excitation coil. By adding a composite shielding structure outside the excitation coil and the detection coil, respectively, the direct coupling energy is effectively restrained. As a result, the size of the probe is reduced. By optimizing the coil spacing and probe placement position, the detection sensitivity of the probe is improved. The simulation is verified by experiments, and the experimental results are consistent with the simulation conclusions.
Numerical Modeling of a New Type of Prosthetic Restoration for Non-Carious Cervical Lesions
Authors: Kamenskikh Anna A. , Sakhabutdinova Lyaysan , Astashina Nataliya , Petrachev Artem , Nosov Yuriy
Published: July 2022

The paper considers a new technology for the treatment of non-carious cervical lesions (NCCLs). The three parameterized numerical models of teeth are constructed: without defect, with a V-shaped defect, and after treatment. A new treatment for NCCL has been proposed. Tooth tissues near the NCCLs are subject to degradation. The main idea of the technology is to increase the cavity for the restoration of NCCLs with removal of the affected tissues. The new treatment method also allows the creation of a playground for attaching the gingival margin. The impact of three biomaterials as restorations is studied: CEREC Blocs; Herculite XRV; and Charisma. The models are deformed by a vertical load from the antagonist tooth from 100 to 1000 N. The tooth-inlay system is considered, taking into account the contact interaction. Qualitative patterns of tooth deformation before and after restoration were established for three variants of the inlay material.
Modified Micro-Mechanics Based Multiscale Model for Damage Analysis of Open-Hole Composite Laminates under Compression
Authors: Wang Meng , Hang Xiaochen
Published: July 2022

The multiscale model based on micro-mechanics failure theory is modified to consider complex internal structures, including a fiber random arrangement pattern and interface with the clustering method. Then, a feed-forward-neural-network (FFNN)-based damage evolution method is developed to evaluate the macroscale property degradation. The progressive damage analysis of open-hole laminates under compression is conducted to validate the modified multiscale method. The predicted results reveal that the interface results in the premature initiation of damage, and the fiber random arrangement pattern contributes to the decrease in the predicted compression responses. The developed FFNN-based method aimed at degradation results in an increase in the predicted compression strength. For the fiber random distribution pattern, the increase in percentage of predicted compressive strength is 6.0%, which is much larger than the value for the fiber diamond distribution pattern.
A Review of Anodized TiNbSn Alloys for Improvement in Layer Quality and Application to Orthopedic Implants
Authors: Mori Yu , Masahashi Naoya , Aizawa Toshimi
Published: July 2022

Titanium alloys are useful for application in orthopedic implants. However, complications, such as prosthetic infections and aseptic loosening, often occur after orthopedic devices are implanted. Therefore, innovation in surface modification techniques is essential to develop orthopedic materials with optimal properties at the biomaterial–bone interface. In this review, we present recent research on the improvement in the osteoconductivity and antibacterial effect of the Ti-33.6% Nb-4% Sn (TiNbSn) alloy by anodic oxidation and other related studies. TiNbSn alloys are excellent new titanium alloys with a low Young’s modulus, high tensile strength, and with gradient functional properties such as a thermally adjustable Young’s modulus and strength. Titanium dioxide (TiO2), when obtained by the anodic oxidation of a TiNbSn alloy, improves bone affinity and provides antibacterial performance owing to its photocatalytic activity. The safety of TiO2 and its strong bonding with metal materials make its method of preparation a promising alternative to conventional methods for improving the surface quality of orthopedic implants. Implementing anodization technology for TiNbSn alloys may alleviate orthopedic surgery-related complications, such as loosening, stress shielding, and infection after arthroplasty.
Bond Behavior of Steel Cords Embedded in Inorganic Mortars
Authors: Roscini Francesca , Guadagnini Maurizio
Published: July 2022

This paper investigates the bond behavior of steel cords embedded in inorganic matrices. A series of pull-out tests were carried out on individual galvanized steel cords embedded in either a cementitious or lime-based mortar matrix and the corresponding bond-slip relationships were derived. The quality of bond between cord and mortar was found to be critically affected by the workability of the mortar and its ability to create adequate composite action along the entire embedment length of the cord. The more workable lime-based mortar was found to guarantee a better interaction with the steel cord, in terms of initial bond stiffness, maximum bond strength, and post-peak behavior. The experimentally derived bond–slip relationships were subsequently integrated in a 3D non-linear finite element framework and used to determine the constitutive relationship of a surface-based cohesive contact between cord and mortar. The cohesive bond behavior was used to conduct a series of parametric studies on cords embedded in a lime-based mortar and examine the stress development within specimens with cords of different embedment lengths and subjected to different loading conditions (i.e., pull-out and direct tension). The active ‘Stress Transfer Zone’ was found to be about 125 mm, while an ‘Effective Transfer Radius’ of approximately 3.5–4 mm was identified. The numerical investigation implemented in this paper enabled one to study key interaction properties of steel reinforced grouts and can assist the design of more effective strengthening solutions.
Surface Functionalisation of Dental Implants with a Composite Coating of Alendronate and Hydrolysed Collagen: DFT and EIS Studies
Authors: Petrović Željka , Šarić Ankica , Despotović Ines , Katić Jozefina , Peter Robert , Petravić Mladen , Ivanda Mile , Petković Marin
Published: July 2022

The success of the osseointegration process depends on the surface characteristics and chemical composition of dental implants. Therefore, the titanium dental implant was functionalised with a composite coating of alendronate and hydrolysed collagen, which are molecules with a positive influence on the bone formation. The results of the quantum chemical calculations at the density functional theory level confirm a spontaneous formation of the composite coating on the titanium implant, ∆G*INT = −8.25 kcal mol−1. The combination of the results of X-ray photoelectron spectroscopy and quantum chemical calculations reveals the structure of the coating. The alendronate molecules dominate in the outer part, while collagen tripeptides prevail in the inner part of the coating. The electrochemical stability and resistivity of the implant modified with the composite coating in a contact with the saliva depend on the chemical nature of alendronate and collagen molecules, as well as their inter- and intramolecular interactions. The formed composite coating provides a 98% protection to the implant after the 7-day immersion in the artificial saliva. From an application point of view, the composite coating could effectively promote osseointegration and improve the implant’s resistivity in contact with an aggressive environment such as saliva.
Sponge-like CoNi Catalysts Synthesized by Combustion of Reactive Solutions: Stability and Performance for CO2 Hydrogenation
Authors: Evdokimenko Nikolay , Yermekova Zhanna , Roslyakov Sergey , Tkachenko Olga , Kapustin Gennady , Bindiug Denis , Kustov Alexander , Mukasyan Alexander S.
Published: July 2022

Active and stable catalysts are essential for effective hydrogenation of gaseous CO2 into valuable chemicals. This work focuses on the structural and catalytic features of single metals, i.e., Co and Ni, as well as bimetallic CoNi alloy catalysts synthesized via combustion of reactive sol-gels. Different characterization methods were used for studying the relationships between the structure, composition, and catalytic activity of the fabricated materials. All catalysts exhibited highly porous sponge-like microstructure. The outermost surfaces of the CoNi alloys were more saturated with Co, while a stoichiometric Co/Ni ratio was observed for the particle’s bulk. Catalytic properties of the as-synthesized powders were studied in the CO2 hydrogenation reaction at 300 °C for over 80 h of time on stream. All the catalysts demonstrated exceptional selectivity with respect to CH4 formation. However, the combination of elemental Co and Ni in a single phase resulted in a synergistic effect in bulk alloy catalysts, with activity twofold to threefold that of single-metal catalysts. The activity and stability of the CoNi3 catalyst were higher than those previously reported for Ni-based catalysts. The reasons for this behavior are discussed.
Shape-Dependent Strength of Al Si9Cu3FeZn Die-Cast Alloy in Impact Zone of Conformal Cooling Core
Authors: Piekło Jarosław , Burbelko Andriy , Garbacz-Klempka Aldona
Published: July 2022

This article presents the results of shape-dependent strength analyses in die-castings from traditional (straight-drilled) and conformal core-cooling moulds. Cores with a traditional cooling layout were made of H13 steel using machining, and the working sections of the conformal cores were made using the selective laser melting method (SLM). Two series of casts were produced in the same mould. For Series A, the mould was fitted with traditional cooling cores, and for Series B, the same mould was fitted with conformal ones. The cast specimens were subjected to two weeks of natural ageing. The strength testing of the casts determined the levels of the destructive forces. The destructive forces in the core-cooling impact zones were approximately 28% higher in the B samples than they were in the A samples. The impact of the alloy’s porosity, density, and microstructure on the strengths of the casts was demonstrated. The alloy densities in the central (broken-off) fragments of the casts from Series A were 2.6646 g/cm3; these were 2.6791 g/cm3 in the cases of casts from Series B. The values of the secondary dendrite arm space (SDAS) ranged from 6 to 13 μm in the analysed cross-section of the set of the A casts, and between 3 and 12 μm in the same zone of the set of the B casts. The results of the experimental determinations of the casts porosity levels and SDAS parameters were compared with the results of numerical simulations that were carried out in ProCAST software.
Investigation of Tensile Properties of Different Infill Pattern Structures of 3D-Printed PLA Polymers: Analysis and Validation Using Finite Element Analysis in ANSYS
Authors: Ganeshkumar S. , Kumar S. Dharani , Magarajan U. , Rajkumar S. , Arulmurugan B. , Sharma Shubham , Li Changhe , Ilyas R. A. , Badran Mohamed Fathy
Published: July 2022

The advancement of 3D-printing technology has ushered in a new era in the production of machine components, building materials, prototypes, and so on. In 3D-printing techniques, the infill reduces the amount of material used, thereby reducing the printing time and sustaining the aesthetics of the products. Infill patterns play a significant role in the property of the material. In this research, the mechanical properties of specimens are investigated for gyroid, rhombile, circular, truncated octahedron, and honeycomb infill structures (hexagonal). Additionally, the tensile properties of PLA 3D-printed objects concerning their infill pattern are demonstrated. The specimens were prepared with various infill patterns to determine the tensile properties. The fracture of the specimen was simulated and the maximum yield strengths for different infill structures and infill densities were determined. The results show the hexagonal pattern of infill holds remarkable mechanical properties compared with the other infill structures. Through the variation of infill density, the desired tensile strength of PLA can be obtained based on the applications and the optimal weight of the printed parts.
A Note on Lagrange Interpolation of |x| on the Chebyshev and Chebyshev–Lobatto Nodal Systems: The Even Cases
Authors: Berriochoa Elías , Cachafeiro Alicia , García-Rábade Héctor , García-Amor José Manuel
Published: July 2022

Throughout this study, we continue the analysis of a recently found out Gibbs–Wilbraham phenomenon, being related to the behavior of the Lagrange interpolation polynomials of the continuous absolute value function. Our study establishes the error of the Lagrange polynomial interpolants of the function |x| on [−1,1], using Chebyshev and Chebyshev–Lobatto nodal systems with an even number of points. Moreover, with respect to the odd cases, relevant changes in the shape and the extrema of the error are given.
MultiSec: Multi-Task Deep Learning Improves Secreted Protein Discovery in Human Body Fluids
Authors: He Kai , Wang Yan , Xie Xuping , Shao Dan
Published: July 2022

Prediction of secreted proteins in human body fluids is essential since secreted proteins hold promise as disease biomarkers. Various approaches have been proposed to predict whether a protein is secreted into a specific fluid by its sequence. However, there may be relationships between different human body fluids when proteins are secreted into these fluids. Current approaches ignore these relationships directly, and therefore their performances are limited. Here, we present MultiSec, an improved approach for secreted protein discovery to exploit relationships between fluids via multi-task learning. Specifically, a sampling-based balance strategy is proposed to solve imbalance problems in all fluids, an effective network is presented to extract features for all fluids, and multi-objective gradient descent is employed to prevent fluids from hurting each other. MultiSec was trained and tested in 17 human body fluids. The comparison benchmarks on the independent testing datasets demonstrate that our approach outperforms other available approaches in all compared fluids.
Modeling the Effect of Target Shape on Movement Performance in a 1D2D Fitts Task
Authors: Lin Chiuhsiang Joe , Cheng Chih-Feng
Published: July 2022

Fitts’ law is used as a performance measurement metric in human–computer interactions. The original formulation implied that movement time was identical for movements with the same value of the index of difficulty under varied movement amplitude and target width. An experiment was designed to test this implication. The result indicates that movement time is related to the index of difficulty when the amplitude is constant. Nowadays, most of the icons in applications are represented as two-dimensional targets. An object of equal width and height is a particular case of a two-dimensional target. This target area could be a factor in a Fitts task and impact the movement time, number of errors, and perceived difficulty. Therefore, the area could replace the target width in the formulation of the index of difficulty. The modified index of difficulty is easy to implement without the complexity of post-calculation. Researchers can design the index of difficulty before the empirical test. This research proposes a modified index of difficulty by varying the target’s area and applying the square-root movement time model simultaneously, which results in an excellent performance with a higher R-square and satisfies the residual normality robustly than the traditional formulation of Fitts’ law.
Redesign of the Statistics Course to Improve Graduates’ Skills
Authors: Benková Marta , Bednárová Dagmar , Bogdanovská Gabriela , Pavlíčková Marcela
Published: July 2022

In general, college students have concerns about mastering the Statistics course. Several scientific articles suggest that methodologies in which the student is an active part of the educational process lead to their greater involvement in teaching activities and better results in their overall assessment. A modified form of the Mathematics course inspires this study. The Mathematics course precedes the Statistics course. This study presents students’ results from both affected courses for the last 12 years. The authors obtained the data from the Modular Academic Information System (MAIS). The study describes the Statistics course, which is a combination of the traditional form of teaching and learning with elements of active learning. The product is a redesign of this course. The proposed changes are based on the requirements of some stakeholders. The results are from a survey of course graduates, from the experience of online teaching during the COVID-19 pandemic, and the introduction of active-learning elements. The authors of the article point out the risks and opportunities they found in teaching the Statistics course.
Vasovagal Reactions during Interventional Pain Management Procedures—A Review of Pathophysiology, Incidence, Risk Factors, Prevention, and Management
Authors: Malave Brian , Vrooman Bruce
Published: July 2022

Vasovagal reactions are a benign but common outcome of interventional pain management procedures that can negatively impact patient care, including aborted procedures and fear of future procedures that would otherwise help the patient. Research has been done on the incidence, risk factors, and management of vasovagal reactions resulting from such procedures, but less is known about how to prevent these reactions from occurring. In this paper, we present a literature review of the pathophysiology, incidence, risk factors, prevention, and management of vasovagal reactions during interventional pain management procedures, with an emphasis on the relative lack of research and conflicting advice on preventive measures. We found that moderate sedation and anxiolytics have been used prophylactically to prevent vasovagal reactions, but their side-effect profiles prevent them from being used commonly. Less studied is the prophylactic administration of antimuscarinics and IV fluids, despite the potential benefit of these measures and relatively low side-effect profile. We explore these topics here and offer advice for future research to fill the gaps in our knowledge.
The Effect of Heat Sterilization on Key Filtration Performance Parameters of a Commercial Polymeric (PVDF) Hollow-Fiber Ultrafiltration Membrane
Authors: Nastouli Alexandra , Tsirigka Asimina , Harasek Michael , Karabelas Anastasios J. , Patsios Sotiris I.
Published: July 2022

Membrane processes can be integrated with fermentation for the selective separation of the products from the fermentation broth. Sterilization with saturated steam under pressure is the most widely used method; however, data concerning heat sterilization applicability to polymeric ultrafiltration (UF) membranes are scarcely available. In this study, the effect of the sterilization process on the filtration performance of a commercial polyvinylidene difluoride (PVDF) hollow fiber UF membrane was evaluated. Membrane modules were constructed and sterilized several times in an autoclave. Pure water flux tests were performed, to assess the effect of heat sterilization on the membrane’s pure water permeance. Dextran rejection tests were performed for the characterization of membrane typical pore size and its fouling propensity. Filtration performance was also assessed by conducting filtration tests with real fermentation broth. After repeated sterilization cycles, pure water permeance remained quite constant, varying between approx. 830 and 990 L·m−2·h−1·bar−1, while the molecular weight cut-off (MWCO) was estimated to be in the range of 31.5–98.0 kDa. Regarding fouling behavior, the trans-membrane pressure increase rate was stable and quite low (between 0.5 and 7.0 mbar/min). The results suggest that commercial PVDF UF membranes are a viable alternative to high-cost ceramic UF membranes for fermentation processes that require heat sterilization.
Inimitable Impacts of Ceramides on Lipid Rafts Formed in Artificial and Natural Cell Membranes
Authors: Kinoshita Masanao , Matsumori Nobuaki
Published: July 2022

Ceramide is the simplest precursor of sphingolipids and is involved in a variety of biological functions ranging from apoptosis to the immune responses. Although ceramide is a minor constituent of plasma membranes, it drastically increases upon cellular stimulation. However, the mechanistic link between ceramide generation and signal transduction remains unknown. To address this issue, the effect of ceramide on phospholipid membranes has been examined in numerous studies. One of the most remarkable findings of these studies is that ceramide induces the coalescence of membrane domains termed lipid rafts. Thus, it has been hypothesised that ceramide exerts its biological activity through the structural alteration of lipid rafts. In the present article, we first discuss the characteristic hydrogen bond functionality of ceramides. Then, we showed the impact of ceramide on the structures of artificial and cell membranes, including the coalescence of the pre-existing lipid raft into a large patch called a signal platform. Moreover, we proposed a possible structure of the signal platform, in which sphingomyelin/cholesterol-rich and sphingomyelin/ceramide-rich domains coexist. This structure is considered to be beneficial because membrane proteins and their inhibitors are separately compartmentalised in those domains. Considering the fact that ceramide/cholesterol content regulates the miscibility of those two domains in model membranes, the association and dissociation of membrane proteins and their inhibitors might be controlled by the contents of ceramide and cholesterol in the signal platform.
Enhanced MEA Performance for an Intermediate-Temperature Fuel Cell with a KH5(PO4)2-Doped Polybenzimidazole Membrane
Authors: Li Yifan , Hu Jing , Papavasiliou Joan , Fu Zhiyong , Chen Li , Li Haibin
Published: July 2022

This work exhibits an effective approach to enhance the performance of membrane-electrode assembly (MEA) with KH5(PO4)2-doped PBI membrane, by adding phosphoric acid (PA) in the catalyst layer (CL). The ohmic resistance and single-cell performance of the MEA, treated with PA, are reduced by ~80% and improved by ~800%, respectively, compared to that of untreated MEA. Based on the MEA pretreated with PA, the influence of humidity and temperature on the resistance and the single-cell performance are investigated. Under humidified gas conditions, the ohmic resistance of MEA is reduced but the charge transfer resistance is slightly increased. Regarding the effect of temperature, the ohmic resistance of MEA becomes lower as the temperature elevates from 140 to 180 °C, but increases at 200 °C. The maximum peak power density presents at 180 °C and 20% RH with 454 mW cm−2. The peak power density is favored with temperature increase from 140 to 180 °C, but decreases with further increase to 200 °C. Moreover, when dry gas conditions are employed, the output performance is unstable, suggesting that humidification is necessary to inhibit degradation for a long-term stability test.
Self-Assembly of Lipid Mixtures in Solutions: Structures, Dynamics Processes and Mechanical Properties
Authors: Sun Lingling , Pan Fan , Li Shiben
Published: July 2022

The self-assembly of lipid mixtures in aqueous solution was investigated by dissipative particle dynamics simulation. Two types of lipid molecules were modelled, where three mixed structures, i.e., the membrane, perforated membrane and vesicle, were determined in the self-assembly processes. Phase behaviour was investigated by using the phase diagrams based on the tail chain lengths for the two types of lipids. Several parameters, such as chain number and average radius of gyration, were employed to explore the structural formations of the membrane and perforated membrane in the dynamic processes. Interface tension was used to demonstrate the mechanical properties of the membrane and perforated membrane in the equilibrium state and dynamics processes. Results help us to understand the self-assembly mechanism of the biomolecule mixtures, which has a potential application for designing the lipid molecule-based bio-membranes in solutions.
Oil-Pipe Cracking and Fitness-for-Service Assessment
Authors: Luo Jin-Heng , Li Li-Feng , Zhu Li-Xia , Zhang Liang , Wu Gang , Zhao Xin-Wei
Published: July 2022

A new D457 × 7.1 X65ERW oil pipeline leaked twice during the pressure test. The two failed oil pipes belonged to the same batch of products from the same manufacturer. Failure analysis showed that the cracks in the 1# and 2# cracking pipes propagated from the outer surface of the pipe wall to the inner surface along the weld fusion line. The inclusion phase distributed in chains in the weld zone is speculated to be the root cause of the cracking in the pressure test. The fitness-for-service of this batch of steel pipes was analyzed using the failure-assessment chart technique. The batch of steel pipes could be used safely under the design pressure of 10 MPa, and the re-evaluation period of three years was recommended for the pipeline based on the fatigue results of the steel-pipe weld zone.
Influence of Deposition Parameters on Structural and Electrochemical Properties of Ti/Ti2N Films Deposited by RF-Magnetron Sputtering
Authors: González-Hernández Andrés , Aperador William , Flores Martín , Onofre-Bustamante Edgar , Bermea Juan E. , Bautista-García Roberto , Gamboa-Soto Federico
Published: July 2022

The titanium nitride (Ti2N) films have good mechanical properties, such as high hardness and chemical stability, giving Ti2N good resistance to wear and corrosion. The properties of films deposited by PVD techniques are determined by their structure, microstructure, composition, and morphology that depend on the deposition parameters, such as substrate temperature, vacuum pressure, and the distance between the target and the substrate. The influence of these parameters has been studied individually. This work studied the structure, morphology, composition, and electrochemical behavior of Ti/Ti2N films deposited by RF-magnetron sputtering on carbon steel, such as a function of the power of the RF source, substrate temperature, and the target to substrate distance and the Ar/N2 ratio. The film structure was analyzed by X-ray diffraction (XRD), the morphology of cross-section by SEM, the semi-quantitative composition by EDS, and the electrochemical properties was studied by open circuit potential, potentiodynamic polarization, and electrochemical impedance spectroscopy techniques. The films showed two phases of Ti and Ti2N. The SEM-EDS exhibited a morphology according to the Stranski–Krastanov or layer-plus-island growth model. The substrate temperature of 450 °C strongly influences the electrochemical properties.
Nanoindentation Investigation of Chloride-Induced Stress Corrosion Crack Propagation in an Austenitic Stainless Steel Weld
Authors: Qu Haozheng J. , Wharry Janelle P.
Published: July 2022

Transgranular chloride-induced stress corrosion cracking (TGCISCC) is a mounting concern for the safety and longevity of arc welds on austenitic stainless steel (AuSS) nuclear waste storage canisters. Recent studies have shown the key role of crystallography in the susceptibility and propagation of TGCISCC in SS weldments. Given that crystallography underlies mechanical heterogeneities, the mechanical-crystallographic relationship during TGCISCC growth must be understood. In this study, welded SS 304L coupons are loaded in four-point bend fixtures and then boiled in magnesium chloride to initiate TGCISCC. Nanoindentation mapping is paired with scanning electron microscopy (SEM) electron backscatter diffraction (EBSD) to understand the correlation between grain orientation, grain boundaries, and hardening from TGCISCC propagation. The nanoindentation hardness of individual grains is found to not be a controlling factor for TGCISCC propagation. However, intragranular hardness is generally highest immediately around the crack due to localized strain hardening at the crack tip. This work shows that nanoindentation techniques can be useful in understanding CISCC behaviors when paired with electron microscopy.
Association of Nasopharyngeal and Serum Glutathione Metabolism with Bronchiolitis Severity and Asthma Risk: A Prospective Multicenter Cohort Study
Authors: Kyo Michihito , Zhu Zhaozhong , Nanishi Makiko , Shibata Ryohei , Ooka Tadao , Freishtat Robert J. , Mansbach Jonathan M. , Camargo Carlos A. , Hasegawa Kohei
Published: July 2022

Infants hospitalized for bronchiolitis are at high risk for asthma. Glutathione-related metabolites may antagonize oxidative stress, which induces airway injuries in respiratory infection and subsequent airway remodeling. However, little is known about the relationship of glutathione-related metabolites with bronchiolitis severity and the risk of asthma. In a multicenter prospective observational cohort study of infants hospitalized for bronchiolitis, we measured nasopharyngeal and serum glutathione-related metabolites by using liquid chromatography–tandem mass spectrometry. We then examined their association with bronchiolitis severity (defined by positive pressure ventilation (PPV) use). We also identified severity-related glutathione-related metabolite signatures and examined their association with asthma at age 6 years. In 1013 infants, we identified 12 nasopharyngeal and 10 serum glutathione-related metabolites. In the multivariable models, lower relative abundances of seven metabolites, e.g., substrates of glutathione, including cysteine (adjOR 0.21, 95%CI 0.06–0.76), glycine (adjOR 0.25, 95%CI 0.07–0.85), and glutamate (adjOR 0.25, 95%CI 0.07–0.88), were significantly associated with PPV use (all FDR < 0.05). These associations were consistent with serum glutathione-related metabolites. The nasopharyngeal glutathione-related metabolite signature was also associated with a significantly higher risk of asthma (adjOR 0.90, 95%CI 0.82–0.99, p = 0.04). In infants hospitalized for bronchiolitis, glutathione-related metabolites were associated with bronchiolitis severity and asthma risk.