bluuebunny/crossref_metadata_2025 huggingface dataset:
Behavioral Mechanisms That Mediate Mental and Physical Health Improvements in People With Chronic Pain Who Receive a Digital Health Intervention: Prospective Cohort Pilot Study
Authors: Cheng Abby L , Agarwal Mansi , Armbrecht Melissa A , Abraham Joanna , Calfee Ryan P , Goss Charles W
Published: November 2023

Background

Preliminary evidence suggests that digital mental health intervention (Wysa for Chronic Pain) can improve mental and physical health in people with chronic musculoskeletal pain and coexisting symptoms of depression or anxiety. However, the behavioral mechanisms through which this intervention acts are not fully understood.

Objective

The purpose of this study was to identify behavioral mechanisms that may mediate changes in mental and physical health associated with use of Wysa for Chronic Pain during orthopedic management of chronic musculoskeletal pain. We hypothesized that improved behavioral activation, pain acceptance, and sleep quality mediate improvements in self-reported mental and physical health.

Methods

In this prospective cohort, pilot mediation analysis, adults with chronic (≥3 months) neck or back pain received the Wysa for Chronic Pain digital intervention, which uses a conversational agent and text-based access to human counselors to deliver cognitive behavioral therapy and related therapeutic content. Patient-reported outcomes and proposed mediators were collected at baseline and 1 month. The exposure of interest was participants’ engagement (ie, total interactions) with the digital intervention. Proposed mediators were assessed using the Behavioral Activation for Depression Scale–Short Form, Chronic Pain Acceptance Questionnaire, and Athens Insomnia Scale. Outcomes included Patient-Reported Outcomes Measurement Information System Anxiety, Depression, Pain Interference, and Physical Function scores. A mediation analysis was conducted using the Baron and Kenny method, adjusting for age, sex, and baseline mediators and outcome values. P<.20 was considered significant for this pilot study.

Results

Among 30 patients (mean age 59, SD 14, years; 21 [70%] female), the mediation effect of behavioral activation on the relationship between increased intervention engagement and improved anxiety symptoms met predefined statistical significance thresholds (indirect effect –0.4, 80% CI –0.7 to –0.1; P=.13, 45% of the total effect). The direction of mediation effect was generally consistent with our hypothesis for all other proposed mediator or outcome relationships, as well.

Conclusions

In a full-sized randomized controlled trial of patients with chronic musculoskeletal pain, behavioral activation, pain acceptance, and sleep quality may play an important role in mediating the relationship between use of a digital mental health intervention (Wysa for Chronic Pain) and improved mental and physical health.

Trial Registration

ClinicalTrials.gov NCT05194722; https://clinicaltrials.gov/ct2/show/NCT05194722
Digital, Personalized Clinical Trials Among Older Adults: Lessons Learned From the COVID-19 Pandemic and Directions for the Future (Preprint)
Authors: Butler Mark , Arader Lindsay , Miller Danielle , Perrin Alexandra , Vicari Frank , Friel Ciaran P. , Vrany Elizabeth , Goodwin Ashley M.
Published: November 2023

UNSTRUCTURED

Background: The COVID-19 pandemic was extremely disruptive to clinical practice and research. Given older adults’ increased likelihood of chronic health concerns, limited resources, and greater risk for adverse outcomes of COVID-19, access to research participation during this time was critical, particularly to interventions that may impact health conditions or behaviors. Fortunately, the implementation of digital research trials during the pandemic allowed for research and intervention delivery for older adults to continue remotely, resulting in feasibility findings that can benefit researchers, practitioners, and the broader older adult population.

Methods/Results: This manuscript discusses three digital, remote, personalized intervention trials implemented during the pandemic to increase physical activity (two trials) or to reduce back pain (one trial). Age cohorts were split between younger (below age 55) and older adults (above age 55) for comparison purposes. Across the three trials, the majority of participants reported high satisfaction with the usability of the trials’ digital systems including text message interventions and surveys (≥62% satisfied) and the use of wearable devices such as Fitbits (≥81% satisfied). In addition, use of the Fitbit device was shown to be feasible, as older adults across all trials wore their Fitbits for the majority of the day [Mean(SD)=20.3(3.6) hours]. Furthermore, consistent Fitbit wear was common; 100% of participants over age 55 wore their Fitbit an average of 10 or more hours per day.

Implications: These trials highlight that digital, remote intervention delivery may be successfully implemented among older adults by way of personalized trials. Across the three digital interventions, feasibility and acceptability were high among older adults, and comparable to younger adults. Further, given the success of the current trials amid pandemic restrictions, we argue that these trials serve as a useful framework to aid in designing digital, remote interventions in other areas of clinical care among older adults and in planning for future disruptions including new pandemics.
A Reliable and Accessible Caregiving Language Model (CaLM) to Support Tools for Caregivers: Development and Evaluation Study (Preprint)
Authors: Parmanto Bambang , Aryoyudanta Bayu , Soekinto Timothius Wilbert , Setiawan I Made Agus , Wang Yuhan , Hu Haomin , Saptono Andi , Choi Yong Kyung
Published: November 2023

BACKGROUND

In the United States, 1 in 5 adults currently serves as a family caregiver for an individual with a serious illness or disability. Unlike professional caregivers, family caregivers often assume this role without formal preparation or training. Thus, there is an urgent need to enhance the capacity of family caregivers to provide quality care. Leveraging technology as an educational tool or an adjunct to care is a promising approach that has the potential to enhance the learning and caregiving capabilities of family caregivers. Large language models (LLMs) can potentially be used as a foundation technology for supporting caregivers. An LLM can be categorized as a foundation model (FM), which is a large-scale model trained on a broad data set that can be adapted to a range of different domain tasks. Despite their potential, FMs have the critical weakness of “hallucination,” where the models generate information that can be misleading or inaccurate. Information reliability is essential when language models are deployed as front-line help tools for caregivers.

OBJECTIVE

This study aimed to (1) develop a reliable caregiving language model (CaLM) by using FMs and a caregiving knowledge base, (2) develop an accessible CaLM using a small FM that requires fewer computing resources, and (3) evaluate the model’s performance compared with a large FM.

METHODS

We developed a CaLM using the retrieval augmented generation (RAG) framework combined with FM fine-tuning for improving the quality of FM answers by grounding the model on a caregiving knowledge base. The key components of the CaLM are the caregiving knowledge base, a fine-tuned FM, and a retriever module. We used 2 small FMs as candidates for the foundation of the CaLM (LLaMA [large language model Meta AI] 2 and Falcon with 7 billion parameters) and adopted a large FM (GPT-3.5 with an estimated 175 billion parameters) as a benchmark. We developed the caregiving knowledge base by gathering various types of documents from the internet. We focused on caregivers of individuals with Alzheimer disease and related dementias. We evaluated the models’ performances using the benchmark metrics commonly used in evaluating language models and their reliability for providing accurate references with their answers.

RESULTS

The RAG framework improved the performance of all FMs used in this study across all measures. As expected, the large FM performed better than the small FMs across all metrics. Interestingly, the small fine-tuned FMs with RAG performed significantly better than GPT 3.5 across all metrics. The fine-tuned LLaMA 2 with a small FM performed better than GPT 3.5 (even with RAG) in returning references with the answers.

CONCLUSIONS

The study shows that a reliable and accessible CaLM can be developed using small FMs with a knowledge base specific to the caregiving domain.
Analytical Review of Medadhatudushti in Prameha
Authors: Sharma Ketan , Kumari Shailza , Veena Veena , Raghuwanshi Manoj Singh
Published: November 2023

Prameha is a lifestyle disorder, described in ancient medical science. It is a sannipataja disorder having predominance of kaphadosha and medodhatudushti. It is produced by the vitiation of ten dusya which include six dhatu, ojus and body fluids. Among ten dusya meda is prime dusya because of similar nature of kapha and meda. Various factors i.e. aharaja and viharaja nidana, increase kapha dosha which in turn vitiates medodhatu. Vitiated kapha affects the medovahasrotasa and medodharakala. Medadhatwaagni gets degraded resulting into improper formation of medadhatu. The abnormal medadhatu is responsible for obesity and prameha. It leads to the manifestation of many purvarupa of prameha & ultimately prabhutaavila mutrata. Assessment of medadusthi is very important for the early diagnosis and proper treatment of prameha.

Keywords: Prameha, Medadhatu, Medadhatwaagni, Medadhatudushti
Associations of Electrocardiographic Abnormalities in Stable Type 2 Diabetes Subjects: Experience from a Tertiary Health Facility in South Eastern Nigeria
Authors: Ezeude CM , Nkpozi MO , Abonyi MC , Onwuegbuna AA , Okechukwu UC , Anyanwu AC , Ikeabbah HE , Ezeude AM
Published: November 2023

Introduction: Cardiovascular abnormalities are prevalent in the setting of diabetes mellitus, even among stable subjects, necessitating the need for a regular cardiovascular disease screening for this group of patients. Electrocardiogram is a simple and reliable screening test for cardiovascular abnormalities that could be easily accessible even in resource poor and rural settings. This study was carried out to determine the association between cardiovascular risk factors and electrocardiographic abnormalities in stable type 2 diabetes subjects in South Eastern Nigeria.

Materials and Methods: One hundred and thirty-six stable adults with type 2 diabetes mellitus were recruited consecutively from the out-patient diabetes clinic of Nnamdi Azikiwe University Teaching Hospital in South Eastern Nigeria. They were assessed for the risk factors for cardiovascular diseases that included smoking, obesity, dyslipidaemia, poor glycaemic control, hypertension, lack of exercise, presence of chronic kidney disease and metabolic syndrome. They also had a 12 lead electrocardiogram done. Results were analyzed using SPSS version 25. P value of ˂ 0.05 was considered significant.

Result: A total of 128 subjects had complete results and were analyzed. There were 63 males and 65 females with a mean age of 58.43 ± 12.85 years and mean diabetes duration of 9.03 ± 7.36 years. A total of 45.3% of the subjects had electrocardiographic abnormalities. Hypertension was present in 54.9%, dyslipidaemia in 91.4%, central obesity in 74.3%, metabolic syndrome in 76.6% and chronic kidney disease in 57.9% of the subjects. Significant association was found between smoking and occurrence of AV block (p = 0.008), central obesity and QRS axis abnormality (p = 0.002), dyslipidaemia and ST segment abnormality (p = 0.001) and lack of exercise and ST segment abnormality (p = 0.000). No significant association was found between age, sex of the subjects, duration of DM, treatment modality for DM, level of glycaemic control, hypertension, presence of CKD and metabolic syndrome and any of the electrocardiographic abnormalities.

Conclusion: Electrocardiographic abnormalities are common in stable type 2 diabetic subjects. There was significant association between smoking habit, central obesity, dyslipidaemia, lack of exercise and ECG abnormalities that included AV block, QRS axis and ST segment abnormalities.
Association between Helicobacter pylori and Diabetes Mellitus
Authors: Moalim Nadar Bashir , Ali Abdelhakam H. , Elsheikh Eslam G. , Ali Dalal B. , Adam Ahmed A.
Published: November 2023

Background: H. pylori is a gram-negative, spiral shaped, Microaerophile pathogenic bacterium that specifically colonizes on the gastric epithelium, it is one of the most common human bacterial pathogens and is the main etiological factor for peptic ulcer disease, simple gastritis and gastric malignancy. The immune status of diabetic patients is compromised, which may lead to an increased susceptibility to H. pylori infection. The aim of this study is to assess Association between Helicobacter pylori and Diabetes Mellitus.

Methods and Material: This was a cross-sectional study with 102 diabetic patients (both IDDM and NIDDM). H.pylori was assessed through the determination of stool antigen by Immunochromatography.

Results: Out of 102 samples were collected from diabetic patients, 58 were male and 44 were female. 52.9% of them are positive for H.pylori and 47.1% are negative. The mean ages of H.pylori positive patients were 44.01 years where the mean age of negative patients were 42.47 years. There was a statistically significance association (p=0.007) between the diabetes and H.Pylori infection, also there was association between history of GIT disorder and H. pylori infection, between smoking and H. pylori infection.

Conclusion: The study showed that Helicobacter pylori infection was significantly higher in diabetes Mellitus.

Keywords: H.pylori, Diabetes Mellitus, T1DM, T2DM
Nanoencapsulation of Rosmarinus officinalis essential oil into Chitosan crosslinked to Tripolyphosphate nanoparticles and Alginate/Chitosan nanoparticles: Formulation, characterization, in vitro release study, and in vivo evaluation
Authors: Hellali Djaafer Hamza , Ayachi Nabila
Published: November 2023

This study delves into the intricate realm of nanoencapsulation, focusing on the application of chitosan crosslinked to TPP and alginate/chitosan-based nanoparticles to encapsulate Rosmarinus officinalis essential oil. The core objective was to unravel the potential pharmacological merits and controlled release dynamics underpinning this novel encapsulation technique. The experimental results painted a compelling portrait of rosemary oil, showcasing its multifaceted efficacy as an antibacterial, antifungal, and antioxidant agent. In the realm of nanotechnology, we were able to formulate nanoparticles under 100 nm, demonstrating exceptional stability. A pivotal aspect of this research revolved around encapsulation efficiency, determined via UV-vis spectroscopy. The results proved staggering, illustrating an encapsulation rate surpassing the 98% benchmark, ensuring minimal essential oil wastage. In vitro assays illuminated the controlled, sustained release attributes of the encapsulated essential oil, thereby further substantiating the potential of this encapsulation approach. FTIR analysis provided insights into the intricate interactions transpiring within these nanoparticles. Venturing into living organisms, our comprehensive in vivo assessments confirmed the significant analgesic activity of our nanoparticles encapsulating rosemary essential oil. This revelation opens exciting prospects for therapeutic applications. Microscopic observations into the SEM solidified the presence and even distribution of these nanoparticles. These compelling findings chart new avenues for the development of more potent, precisely targeted pharmaceutical interventions.

Keywords: Rosemary essential oil, chitosan, sodium alginate, polymeric nanoparticles, nanoencapsulation
Average Per Capita Income as a Condition for Social Protection of the Population
Authors:   Saratov State Academy of Law, Gerasimova E.A. , Eremin V.V. ,   Saratov State Law Academy
Published: November 2023

The average per capita income is considered as a condition for social protection of the population at the present stage and in retrospect. The author’s position is presented regarding the validity of this rule within the framework of individual vectors of social security, and recommendations for further legal regulation are formulated.
Organizational and Managerial Ways to Increase the Level of Guarantees of Constitutional Rights and Freedoms of an Individual in Crisis Conditions
Authors:   Saint-Petersburg State University of Economics, Zakharikhina А.А.
Published: November 2023

Problems of organizing the provision of human and civil rights and freedoms in a crisis are considered. It is proposed to fix organizational and managerial ways to increase the level of guarantees for the exercise of rights in a strategic document with a description of the modular scheme of the document and a definition of risks and ways to manage them.
Analisis Manajemen Proyek dengan Sistem Umbrella Contract Menggunakan Metode Time Cost Trade Off (Studi Kasus: PT Jaya Inti Teklindo)
Authors: Sulistyo Arif Budi , Kusdianto Alfin , Wirawati Sri Mukti
Published: November 2023

PT Jaya Inti Teklindo adalah perusahaan penyedia manpower, service and supply dibidang kontruksi. Studi kasus pada penelitian ini yaitu proyek kontruksi penggantian kompresor lama dengan yang baru. Penelitian ini bertujuan untuk menentukan kegiatan apa saja yang termasuk jalur kritis, melakukan perbandingan waktu dan biaya tenagaikerja akibat penambahanijamikerjaidan menentukan waktuisertaibiaya yang optimal untuk menyelesaikan proyek tersebut. Tahapan penelitian ini adalah pencarian kegiatan jalur kritis menggunakan program Microsoft Project, melakukan analisis percepatan durasi dan biaya tenaga kerja pada jalur kritis dengan variabel penambahanijamikerjaimenggunakan pendekatan TimeiCostiTradeiOff. Berdasarkan hasil analisisidan perhitungan, biayaitenaga kerja normal denganidurasi 70 hari yaitu sebesar Rp 332.119.200. Kemudian dilakukan percepatan sehingga menghasilkan waktu optimal penambahan 3 jam kerja, dengan durasi menjadi 59 hari dan biaya sebesar Rp 413.932.210 dengan menghemat waktu 11 hari dan selisih biaya Rp 81.813.110 dari biaya normal.
Penentuan Jumlah Penggunaan Bahan Baku Tepung Terigu Berdasarkan Simulasi Monte Carlo
Authors: Natalia Christine , Oktavia Chendrasari Wahyu
Published: November 2023

Perusahaan XYZ yang bergerak di bidang pengolahan roti bergantung pada bahan baku yang dibutuhkan cukup besar yaitu tepung terigu. Akan tetapi, ketidakpastian dari hasil penjualan roti mempengaruhi pemakaian kebutuhan bahan baku menjadi tidak menentu. Ketidakpastian tersebut pernah dialami oleh perusahaan yaitu di bulan Oktober pada minggu ke-2 sehingga mengalami kekurangan bahan baku tepung terigu yang cukup besar sebesar 2.554 kg dari kebutuhan bahan baku sebesar 7.086 kg.  Faktor penyebab dari kekurangan tepung terigu saat ini adalah metode peramalan yang digunakan perusahaan belum tepat sehingga dijumpai permasalahan kekurangan persediaan tepung terigu karena ketidakakuratan hasil yang diperoleh pada bulan Oktober. Oleh karena itu, tujuan penelitian ini adalah menentukan besarnya kebutuhan bahan baku yang mendekati kondisi aktual dengan menggunakan teknik peramalan dengan simulasi monte carlo. Hasil dari penelitian ini diperoleh perbandingan ukuran akurasi peramalan terhadap kondisi aktual simulasi monte carlo sebesar 102%. Berdasarkan hasil ukuran akurasi simulasi monte carlo mampu mendekati hasil sebenarnya.
Pengembangan Model Kriteria Penilaian Manajemen Risiko Halal Supply Chain Daging pada Bagian Downstream di Indonesia
Authors: Rishelin Nadya , Ardi Romadhani , Suryadi Ismet
Published: November 2023

Daging termasuk salah satu produk yang didinginkan (cold chain) sehingga lebih sensitif terhadap kontaminasi dengan bakteri dan non-halal. Bagian downstream pada supply chain daging di Indonesia terdiri dari logistik, wholesaler, dan food services. Penelitian ini bertujuan menghasilkan pengembangan model kriteria penilaian halal supply chain daging di bagian downstream Indonesia. Kurangnya model kriteria penilaian pada industri makanan halal menyebabkan masih terdapat kemungkinan kontaminasi dengan non-halal sehingga dapat meningkatkan risiko integritas halal. Penelitian ini memiliki tiga tahap yaitu identifikasi risiko halal suppy chain daging berdasarkan literatur dan validasi oleh ahli, prioritas risiko menggunakan metode DANP, serta pengembangan model kriteria penilaian halal supply chain daging berdasarkan prioritas risiko dan validasi oleh ahli. Temuan penelitian menunjukkan 44 kriteria penilaian halal supply chain daging pada downstream di Indonesia. Aktor logistik dan wholesaler merupakan penambahan aktor yang dapat digunakan sebagai kriteria tambahan. Kriteria penilaian ini dapat digunakan oleh pembuat kebijakan setiap aktor untuk menjaga status halal.
Optimalisasi Perencanaan Produksi dengan Metode Integer Linear Programming: Studi Kasus Manufaktur Paper Core
Authors: Hendrata Yohannes , Sumaverdy Muhammad Egi , Asrol Muhammad
Published: November 2023

Penelitian ini bertujuan mengatasi masalah mendesak yang dihadapi perusahaan manufaktur kertas paper core untuk memenuhi permintaan pelanggan, dengan optimalisasi perencanaan produksi dan urutan proses yang efisien. Penelitian menggunakan metode algoritma simpleks dan Integer Linear Programming untuk mengoptimalkan keuntungan melalui penjadwalan produksi paper core. Dua metode perangkat lunak Excel Solver dan Lingo, diterapkan untuk menemukan solusi optimal serta mematuhi semua batasan yang ada. Hasil penelitian menunjukkan dengan metode ILP, jumlah produksi tertinggi tercapai pada produk X4 (item C50C40TK) sebanyak 21.600 unit di mesin1, lalu produk X9 (item C50B17TR) sebanyak 4.320 unit di mesin2. Marjin keuntungan diperoleh sebesar IDR 4.835.880,- untuk proses 2 hari kerja. Ini menunjukkan perbaikan signifikan sebesar 18,8% dibandingkan marjin operasional sebelumnya sebesar IDR 4.069.800,-. Dalam kesimpulan nya, penelitian menunjukkan penerapan metode Linier Programming memberikan panduan berharga bagi perusahaan untuk meningkatkan efisiensi produksi dan keuntungan di masa depan.
Implementasi Design For Assembly (DFA) Pada Desain Produk Oven
Authors: Firmansyah M. Muchlas , Jakaria Ribangun Bamban
Published: November 2023

Oven merupakan hasil industri kerajinan almuinium dan stainless yang berfungsi untuk memanaskan, memanggang, dan mengeringkan yang biasa diguanakan dalam kegiatan rumah tangga maupun industri. Adapun masalah yang sering dihadapi para produsen oven manajemen inovasi yang kurang. Produsen masih mengandalkan cara lama untuk memproduksi produk oven dengan hanya mengandalkan palu dan gunting serta keahlian pengrajin yang minim inovasi, oleh sebab itu belum adanya strategi menentukan desain yang tepat untuk memenuhi keinginan konsumen sehingga menyebabkan tingkat penjualan yang belum maksimal. Dalam penelitian ini kita menganalisa menggunakan metode Design for Assembly (DFA) di dalam mengetahui metode yang tepat dalam merancang desain produk oven. Dari penelitian ini diharapkan dapat memberikan apa saja yang dibutuhkan pelaku UMKM oven agar meningkatkan kualitas produk oven serta mendapatkan gambaran secara detail apa saja yang harus di lakukan untuk memaksimalkan produksi supaya kebutuhan model dan desain konsumen dapat terpenuhi dan mendapatkan peningkatan jumlah produksi.
Neglected data about the year of construction of the church of the virgin in Studenica
Authors: Markovic Miodrag
Published: November 2023

The text deals with two mutually close, late sources that have not been used
so far in considering the chronology of the construction of the katholikon
of the Studenica monastery: the inscriptions on two copper engravings
depicting the main church of the ?Great Lavra of St. Simeon? made in Moscow
in 1758. Those inscriptions state, among other things, that Stefan Nemanja
built the Church of the Assumption of the Virgin Mary in 1194/1195.
Specialized Retinal Endothelial Cells Modulates Blood-Retina- Barrier in Diabetic Retinopathy
Authors: Yao Xuyang , Zhao Ziyan , Zhang Wenhui , Liu Ruixin , Ni Tianwen , Cui Bohao , Lei Yi , Du Jie , Ai Ding , Jiang Hongfeng , Lv Huizhen , Li Xiaorong
Published: November 2023

Abstract

Endothelial cells (EC) play essential roles in retinal vascular homeostasis. This study aimed to characterize retinal EC heterogeneity and functional diversity using single-cell RNA sequencing. Systematic analysis of cellular compositions and cell-cell interaction networks identified a unique EC cluster with high inflammatory gene expression in diabetic retina; sphingolipid metabolism is a prominent aspect correlated with changes in retinal function. Among sphingolipid-related genes, alkaline ceramidase 2 (ACER2) showed the most significant increase. Plasma samples of patients with non-proliferative diabetic retinopathy (NPDR) with or without diabetic macular edema (DME) and active PDR were collected for mass spectrometry analysis. Metabolomic profiling revealed that the ceramide levels were significantly elevated in NPDR-NDME/DME and further increased in active PDR compared with control patients. In vitro analyses showed that ACER2 overexpression retarded endothelial barrier breakdown induced by ceramide, while silencing of ACER2 further disrupted the injury. Moreover, intravitreal injection of the recombinant ACER2 adeno-associated virus rescued diabetes-induced vessel leakiness, inflammatory response, and neurovascular disease in diabetic mouse models. Together, this study revealed a new diabetes-specific retinal EC population and a negative feedback regulation pathway that reduces ceramide content and endothelial dysfunction by upregulating ACER2 expression. These findings provide insights into cell-type targeted interventions for diabetic retinopathy.

Keywords: diabetes, retina, endothelial cells, blood-retina-barrier, ACER2

Article Highlights

v Endothelial cells (EC) play essential roles in retinal vascular homeostasis. We aimed to characterize retinal EC heterogeneity and functional diversity using single-cell RNA sequencing

v We investigated whether the sphingolipid metabolism involved in diabetes-induced retinal endothelial dysfunction and vascular permeability

v We found a new diabetes-specific retinal EC population and a negative feedback regulation pathway that reduces ceramide content and endothelial dysfunction by upregulating ACER2 expression

v Our study provide insights into cell-type targeted interventions for diabetic retinopathy
Inmixed and Bellicose-Adenosquamous Carcinoma-Uterine Cervix
Authors: A Bajaj
Published: November 2023

Adenosquamous carcinoma of uterine cervix is a preponderantly high grade neoplasm configured of admixed glandular articulations and squamous epithelium wherein glassy cell carcinoma emerges as an exceptional, aggressive variant. Adenosquamous carcinoma is posited to arise from sub-columnar reserve cells confined to endocervical basal epithelium. Cytological smears depict papillary articulations admixed with bland columnar epithelial cells and high grade squamous intraepithelial lesion. The biphasic tumour is composed of well defined, malignant components of glandular articulations and poorly differentiated squamous epithelium. Glassy cell carcinoma demonstrates solid cell nests comprised of pleomorphic, polygonal tumour cells pervaded with glassy, eosinophilic cytoplasm, enlarged, eosinophilic nuclei, prominent nucleoli and distinct cytoplasmic membrane. Neoplastic cells appear enmeshed within an intense inflammatory cell infiltrate with significant eosinophils. Glassy cell carcinoma appears immune reactive to MUC1, MUC2, epithelial membrane antigen (EMA), CAM5.2 or p63 with focal immune reactivity to carcinoembryonic antigen (CEA). Adenosquamous carcinoma requires segregation from neoplasms such as adenocarcinoma with coexisting squamous intraepithelial lesion (SIL), adenoid basal carcinoma, cervical extension of endometrial adenocarcinoma, and squamous cell carcinoma with focal mucin droplets, large cell non keratinizing squamous cell carcinoma or lymphoepithelioma-like carcinoma. Tumefaction may be appropriately treated by radical abdominal hysterectomy followed by adjuvant chemotherapy and radiation therapy.
Kelayakan Konseling Cognitive Behavior Teknik Restrukturisasi Kognitif Berbasis Website LMS Schoology Untuk Meningkatkan Self Efficacy Siswa
Authors: Oktavia Ni Putu Bella Bella , Suranata Kadek , Dwiarwati Kadek Ari
Published: November 2023

Abstrak

Studi ini bertujuan untuk menguji keberterimaan dan keefektifan konseling cognitive behavior dengan teknik restrukturisasi kognitif berbasis website LMS Schoology dalam meningkatkan self efficacy siswa. Studi ini dilakukan berdasarkan prosedur penelitian pengembangan mengikuti model pengembangan 4D oleh Thiagarajan. Subjek penelitian terdiri dari 3 orang praktisi dan ahli yang menilai sistem konseling secara teoretis, juga melibatkan 30 orang siswa sebagai responden uji coba terbatas keefektifan sistem konseling. Data tentang keberterimaan, kemudahan akses, dan kebermanfaatan sistem dan modul konseling diperoleh melalui skala AAF, dan data efficacy diperoleh melalui skala efikasi. Analisis data terkait keberterimaan sistem konseling atau validitas teoretis berdasarkan penilaian praktisi dan ahli dilakukan menggunakan perhitungan content validity ratio. Analisis stastitik uji t-test untuk menguji efektifitas sistem konseling setelah uji coba terbatas. Tanggapan siswa peserta uji coba terhadap keberterimaan, kemudahan akses dan kebermanfaatan konseling ognitive behavior dengan teknik restrukturisasi kognitif berbasis website LMS Schoology dideskripsikan dan dilakukan analisis presentase. Hasil penelitian menunjukkan bahwa sistem dan panduan konseling cognitive behavior memiliki indeks validitas isi atau CVI sebesar 0,95 yang berarti sangat baik. Uji efektifitas melalui uji emperik terbatas menunjuukan bahwa  nilai t sebesar 4.26, pada p> 0.05 yang menunjukkan bahwa  konseling cognitive behavior teknik restrukturisasi kognitif berbasis website LMS schoology efektif meningkatkan self efficacy siswa. Tanggapan siswa terhadap keberterimaan, kemudahan akses dan kebermanfaatan sistem dan panduan konseling dalam kategori baik, dengan indeks rata-rata lebih daru 50% siswa setuju sistem konseling dan modul panduan mudah dipahami dan dilaksanakan, mudah diakses dan bermanfaat. Hasil penelitian ini berimplikasi terhadap pengembangan dan inovasi layanan bimbingan dan konseling di sekolah berbasis ICT, khususnya menggunakan LMS.

 
Urgensi asesmen dalam bimbingan dan konseling dalam menyiapkan generasi berkualitas
Authors: Fitriana Fitriana , Yulianti Yulianti , Yusuf A. Muri , Daharnis Daharnis
Published: November 2023

Students can develop in an optimal direction, which is the dream of each individual, parents, teachers, and the whole community, especially with the condition of a quality generation. The quality of the generation is not achieved quickly, but rather the process and cooperation between personnel, one of which is Guidance and Counseling teachers. Guidance and Counseling teachers act as one of the core personnel in developing students' potential. The implementation is of course adapted to the needs of students because each individual is unique, so the urgency of assessment in guidance and counseling is unavoidable. Through the assessment, a lot of information was obtained, the majority of which were authentic and systematic, so that Guidance and Counseling teachers could easily follow up on the results of the assessment. Furthermore, to deepen this matter, a research is carried out using the method data collection in the form of decommunation. This article aims to elaborate the theory in the form of 1) understanding of guidance and counseling assessment 2) principles of guidance and counseling assessment, 3) the urgency of guidance and counseling assessment in preparing a quality generation.
Perencanaan penganggaran pendidikan berbasis manajemen biaya terpadu di sekolah menengah atas
Authors: Wesmi Wesmi , Suatrina Yenita , Priya Priya , Asmendri Asmendri , Sari Milya
Published: November 2023

Penelitian ini bertujuan untuk menganalisis perencanaan penganggaran pendidikan berbasis manajemen biaya terpadu di SMA Negeri 1 Talamau,Jalan Teluk Embun Nagari Sinuruik, Kecamatan Talamau, Kabupaten Pasaman Barat, Sumatera Barat. Dalam menghadapi tantangan pendidikan modern, perencanaan anggaran yang efektif dan efisien menjadi kunci untuk meningkatkan kualitas pendidikan. Penelitian ini melibatkan analisis data sekunder berdasarkan laporan anggaran sekolah serta wawancara dengan pihak terkait di SMA Negeri 1 Talamau. Hasil penelitian ini mengungkapkan aspek-aspek kritis dalam perencanaan anggaran pendidikan, termasuk alokasi sumber daya, efektivitas komunikasi, pengelolaan biaya, pengelolaan kelas, dan peran kepemimpinan kepala sekolah. Rekomendasi yang disusun bertujuan untuk meningkatkan perencanaan penganggaran pendidikan di sekolah. Hasil penelitian ini dapat menjadi panduan bagi sekolah lain dalam mengembangkan perencanaan anggaran yang berbasis manajemen biaya terpadu.
The effectiveness of moodle-based e-learning in enhancing digital literacy among village owned enterprises
Authors: Puspitasari Lia Pebriana , Sumaryati Sri , Sudiyanto Sudiyanto
Published: November 2023

Amid the global spread of the Covid-19 pandemic, including in Indonesia, several activities have been forcibly halted to prevent wider transmission and avoid more severe impacts. This decision has affected the dynamics of education and training, prompting an increase in the use of E-Learning applications. E-Learning has become a crucial method in creating a supportive learning environment and enhancing learners' performance. The development and expansion of e-learning are made easy with Learning Management System (LMS) software, such as Moodle. This study utilizes the ADDIE research model (Analyze, Design, Develop, Implement, and Evaluate). The data analysis techniques employed include feasibility analysis and learning outcome analysis. Learning outcomes are compared using the paired sample t-test, assisted by SPSS software. Media expert assessments yielded an average score of 4.54 for the presentation aspect, indicating an ideal score of 90.85%, while the programming aspect scored 84% in terms of idealness. Material expert assessments, on the other hand, received an average score of 4.62 for the learning aspect, with an ideal score of 92.3%, and 4.57 for the material aspect, indicating an ideal score of 91.4%. The paired sample t-test analysis produced a Sig. (2-tailed) value of 0.000 with a significance level of 5%. This result indicates that the Sig. (2-tailed) value is less than α = 0.05. Therefore, it can be concluded that the hypothesis is accepted. Consequently, it can be inferred that the use of Moodle-based E-Learning products is effective in enhancing digital literacy among the managers of Bina Sejahtera Village Owned Enterprises.
Antara tradisi dan transformasi: Pandangan santri terhadap istilah guru dan ustadz di Pondok Pesantren Al Hidayah Karangploso Malang
Authors:   Universitas Islam Negeri Maulana Malik Ibrahim Malang, Zahro' Fatimatuz
Published: November 2023

The oldest Islamic educational institution in Indonesia is the Islamic Boarding School which is based on tafaqquh fiddin. Islamic boarding schools are positive environments that have their own characteristics. In Islamic boarding schools there are several elements such as kiai, ustadz, santri, education and Islamic boarding school. In this case, the researcher wants to know the views of students regarding the term teacher/ustadz at the Al Hidayah Islamic Boarding School. Using qualitative descriptive methods. This research data was obtained from primary and secondary data. Data obtained from interviews and observations are collected according to topic, then the data is sorted according to the research objectives and then analyzed according to related references. Therefore, the following research results were obtained: first, there was recognition from the students that teachers/clerics are figures who educate both physically and mentally. Second, the differences in terms are influenced by three things, namely the environment, seniors, and the subjects taught. Third, the embodiment of hierarchy in the educational process. Fourth, the use of these terms has the same substance, namely glorifying teachers/ustadz as a form of service and character. Fifth, the dhurriyah side. sixth, scientific quality, according to the material taught in a lesson. And the implication of this research is that the equality of students' levels of devotion to teachers or ustadz is very different, which is influenced by their profile and background. Keywords: santri, guru, ustadz
Mitigating Heat Exposure: Exploring the Role of Knowledge, Risk Perception, and Precautionary Behavior
Authors: Permatasari Noviyanti , Yovi Efi Yuliati , Kuncahyo Budi
Published: November 2023

Increasing ambient temperatures due to climate change have significantly impacted workers’ physical and mental workloads, affecting their health and safety. Promoting precautionary behaviors, especially among outdoor workers, is an effective strategy widely recommended for addressing these challenges. Precautionary behavior represents an essential protective mechanism that can be adopted at the individual level. This study explores the connections among Occupational Safety and Health (OSH), risk perception, and precautionary behavior. Descriptive statistics and Structural Equation Modeling with the Partial Least Squares approach were used to analyze the data. This study was conducted at two forest management units in Central Java and East Java, Indonesia, where daily air temperatures are relatively high. The research involved 100 respondents, comprising 50 indoor and 50 outdoor workers. The findings of this investigation reveal that OSH-related knowledge among indoor workers predicts their precautionary behavior. Nevertheless, according to the model, attempts to improve precautionary behavior through knowledge enhancement are estimated to be unsuccessful among outdoor workers. Nonetheless, OSH-related knowledge can facilitate workers in developing a more realistic perception, especially regarding the “dread risk factor” among forestry workers, which can positively impact their precautionary behavior.
Keywords: forestry worker, heat exposure, mediation analysis, occupational health, psychometrics paradigm
PENINGKATAN PENGETAHUAN FAKTOR RISIKO HIV-AIDS PADA PENGUNJUNG LAYANAN VOLUNTARY CLINICAL TEST (VCT) DI PUSKESMAS KEMILING BANDAR LAMPUNG UNTUK MENGURANGI PENULARAN HIV-AIDS
Authors: Wardani Dyah Wulan Sumekar Rengganis , Zuraida Reni , Pramesona Bayu Anggileo , Fiana Dewi Nur
Published: November 2023

Kemajuan dalam melawan Human Immunodeficiency Virus/ Acquired Immuno Deficiency Syndrome (HIV-AIDS) diukur melalui insiden dan kematian. Di Indonesia, insiden HIV-AIDS pada 2018 sebesar 46.000 kasus (42.000 – 50.000), menurun dibandingkan insiden pada 2010 sebesar 63.000 kasus (57.000 – 68.000). Akan tetapi, jumlah kematian meningkat, yaitu 38.000 kematian (33.000 – 43.000) pada 2018 dibandingkan 24.000 kematian (19.000 – 28.000) pada 2010. Terdapat beberapa kelompok yang berisiko lebih besar untuk terjadinya HIV-AIDS, yaitu wanita pekerja seks, pengguna narkoba suntik, gay, transgender dan klien pekerja seks. Bandar Lampung merupakan kota dengan kasus HIV-AIDS tertinggi di Provinsi Lampung yaitu 1.480 kasus pada periode 2015 – 2019. Di Bandar Lampung telah terdapat beberapa puskesmas yang memberikan pelayanan voluntary counselling test (VCT), yang diperuntukkan bagi orang yang mempunyai risiko tinggi terhadap HIV-AIDS, salah satunya adalah Puskesmas Kemiling. Pada kegiatan pengabdian ini akan dilakukan peningkatan pengetahuan pengunjung VCT Puskesmas Kemiling tentang faktor risiko HIV-AIDS. Kegiatan pengabdian mencakup Focus Group Discussion, penyusunan media informasi dan penyuluhan yang dilakukan pada tanggal 20 – 30 Agustus 2021. Evaluasi hasil kegiatan pengabdian dilakukan dengan pretest dan post test yang menunjukkan adanya peningkatan pengetahuan. Dapat disimpulkan bahwa kegiatan pengabdian ini dapat meningkatkan pengetahuan para pengunjung VCT Puskesmas Kemiling.
OPTIMALISASI FUNGSI LAHAN PEKARANGAN SEBAGAI KEBUN HIDROPONIK GUNA MENDUKUNG EKONOMI KELUARGA DI DESA BORISALLO KECAMATAN PARANGLOE KABUPATEN GOWA
Authors: Nashrah  , Ansarullah
Published: November 2023

Desa Borisallo merupakan sebuah desa kecil yang makmur dengan hasil pertanian. Sebagian besar wilayahnya adalah lahan sawah yang bisa panen padi dua sampai tiga kali dalam setahun. Sepanjang tahun, warga Desa Borisallo hanya menanam jenis tanaman padi di sawahnya. Sehingga, untuk kebutuhan pangan yang lain, seperti sayur, bumbu masak, dan buah, mereka harus membeli di pasar terdekat. Padahal, sebenarnya warga desa bisa memanfaatkan lahan pekarangan yang ada di sekitar mereka untuk menanam jenis tanaman sayur, bumbu masak, maupun buah-buahan. Namun, mereka kurang memiliki pengetahuan tentang cara pemanfaatan lahan pekarangan maupun prospeknya. Maka dari itu, kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan edukasi kepada masyarakat Desa Borisallo tentang cara mengoptimalkan pemanfaatan lahan pekarangan sehingga dapat membantu ekonomi keluarga. Metode yang digunakan dalam kegiatan pengabdian ini adalah metode edukasi dan  potensi desa. Dimana masyarakat terlebih dahulu diberikan penyuluhan tentang manfaat dan hasil yang bisa didapatkan dari pemanfaatan lahan pekarangan. Dengan pemanfaatan pekarangan secara hidroponik, maka lahan pekarangan dapat lebih optimal dan maksimal. Masyarakat desa bisa menambahkan jenis tanaman lain sesuai dengan kebutuhan mereka. Dengan demikian, pemanfaatan lahan pekarangan secara optimal selain dapat memenuhi kebutuhan pangan keluarga juga dapat membantu menambah pendapatan keluarga.
IBM MENINGKATKAN KREATIFITAS SANTRI PONDOK PESANTREN DENGAN BEKAL ILMU TEKNIK OTOMOTIF 4 TAK
Authors: Prayitno Sugeng , Marasabessy Amir , Hatuwe Rusdy
Published: November 2023

: Pondok Pesantren Minhajjushshobiriin yang berada di bawah Yayasan tersebut yang terletak di Kelurahan Cibubur , Kecamatan Ciracas Jaktim Provinsi DKI merupakan sebuah lembaga pendidikan keagamaan yang telah lama berdiri. Pondok ini menampung siswa-santri dari masyarakat sekitar dan ada juga yang datang dari luar kota Jakarta. Setiap hari para santri belajar ilmu agama Islam. Selain itu ada juga kegiatan majlis talim bagi para bapak dan ibu yang diadakan seminggu sekali.Permasalahan yang dihadapi oleh para santri adalah timbulnya rasa bosan karena setiap hari yang dipelajari hanya ilmu agama Islam saja.Mereka menginginkan ada pelajaran lain sebagai ekstra kurikuler yang menarik sehingga tidak membosankan dan berguna suatu saat kelak setelah lulus dari pesantren. Setidaknya mereka mempunyai keterampilan lain untuk menunjang kegiatan utamanya sebagai da’i. Pimpinan Pondok sangat merespon akan hal ini dan gayungpun bersambut. Tim Dosen dari Fakultas Teknik UPN Veteran Jakarta segera menawarkan Program Pelatihan Teknik Otomotif 4 T (Sepeda Motor/mobil). Pelatihan dilaksanakan setiap hari sabtu dan minggu selama dua bulan yang tidak full karena diselingi dengan kegiatan majlis talim. Kegiatan ini diikuti oleh 60 orang yang terdiri dari siswa santri 50 oraang dan para bapak dan para jamaah majlis talim sebanyak 10 orang.    Tujuan dari pelatihan ini adalah agar para santri dan jamaah majlis talim dapat mengetahui tentang cara merawat mobil/motor 4 T agar kondisinya tetap seperti baru sehingga bertahan lebih lama/awet. Adapun metoda yang diberikan adalah dengan pemberian teori dan praktek tentang power motor 4T bensin (kosntruksi silinder,power,transmisi,kopling,rem hidrolik, pelumas dan pendingin) dan diesel (power injection/nozel,transmisi dll.) beserta semua permasalahan dan solusinya. Hasil dari kegiatan tersebut para santri dan jamaah majlis talim merasa senang karena diberi ilmu yang bermanfaat berupa ilmu pengetahuan praktis yang mudah dipelajari. Setelah diamati dampak dari pelatihan ini ternyata sangat positip. Hal itu dibuktikan dari rasa percaya diri para santri dan jamaah majlis talim semakin tinggi dalam belajar dan bekerja sehingga ada yang bercita-cita ingin membuka bengkel /servis kendaraan.
Aplikasi Bata Api pada Modifikasi Tungku Pemasakan Keripik Singkong IKM Desa Purworejo Kecamatan Negerikaton, Kabupaten Pesawaran
Authors: Wardono Herry , Hanif Muhammad , Risano A. Yudi Eka
Published: November 2023

The communities of cassava chips apply conventional cooking stoves, which are wasteful of fuel, high air pollution, unclean working environment, and cracks quickly. The technology of refractory brick stove with a modification of the combustion chamber is applied to this cooking stove. A new furnace was made using SK-34 refractory bricks. The stove construction requires little skill and is easy to implement. The results obtained from the stove are much more robust, fuel-efficient, and a clean, healthy and comfortable working environment. In addition, because it is easy to manufacture, people will easily understand and make their refractory brick stove and maintain it. Using a refractory brick stove to produce 40 kg of cassava chips requires a frying time of 2 hours 22 minutes and consumes 89.4 kg of firewood. Meanwhile, using a conventional stove takes a frying time of 3 hours 23 minutes and consumes 117.3 kg of firewood.
PENYULUHAN IMPLEMENTASI PROTOKOL KESEHATAN DAN KESELAMATAN KERJA BAGI TUKANG BANGUNAN DI PROYEK RUMAH SEDERHANA KOTA PALU
Authors: Labaso Eko R. , Tahir Anas , Mashuri Mashuri , Patunrangi Jurair
Published: November 2023

Pandemi covid 19 yang melanda dunia menyebabkan kehidupan manusia menjadi “new normal”. Kondisi ini mengharuskan manusia mulai menerapkan protokol kesehatan dalam kehidupan setiap hari. Menggunakan masker, mencuci tangan serta menjaga jarak menjadi kewajiban yang harus ditaati dalam kehidupan sehari-hari. Permasalahan yang terlihat secara langsung di lokasi proyek pembangunan rumah sederhana di Kota Palu yaitu tukang bangunan belum menerapkan protokol kesehatan secara menyeluruh. Kondisi ini tentunya berdampak secara langsung terhadap kesehatan secara individu. Melihat permasalahan tersebut, maka pengabdian kepada masyarakat ini dilakukan untuk memberikan penyuluhan tentang implementasi protokol kesehatan dan keselamatan kerja yang dapat diterapkan bagi tukang bangunan rumah sederhana tanpa menghambat kinerja mereka. Kegiatan pengabdian masyarakat diharapkan dapat menambah pengetahuan bagi tukang bangunan rumah sederhana tentang protokol kesehatan dan keselamatan kerja dan mengimplementasikan dalam kegiatan hariannya.
BANTUAN TEKNIS PRA DESAIN RENOVASI MUSHALLA AT-TAQWA DUSUN ADIMULYO, KAMPUNG ADIJAYA KECAMATAN TERBANGGI BESAR, KABUPATEN LAMPUNG TENGAH
Authors: Kurniawan Panji , Nugroho Agung Cahyo , Hardilla Dini , Ifadianto Nugroho
Published: November 2023

Pembangunan diberbagai bidang terus berkembang saat ini. Peningkatan terhadap kualitas hidup, tidak hanya tidak hanya di tandai dengan meningkatnya kesejahteraan, namun juga pada konteks hubungan dengan sang maha pencipta, Allah SWT. Hubungan komunikasi antara mahluk dan tuhannya di wadahi pada bentuk fisik tertentu. Misalnya yang dilakukan pada pengabdian kali ini yaitu Rencana Renovasi Mushalla At-Taqwa yang berada di dusun Sidomulyo, kampung Adijaya, Kecamatan Terbanggi Besar, Lampung Tengah dengan cara membuat gambar pra desain mushalla At-Taqwa yang ditujukan untuk membantu masyarakat yang berada di sekitar Mushalla At- Taqwa, agar dapat memperkirakan kebutuhan ruang, tata letak ruang, letak sarana pendukung Mushalla dalam sebuah bentuk kegiatan Renovasi. Hal ini menjadi penting karena kondisi eksisting Mushalla ini sudah memerlukan perawatan atau bahkan penggantian bangunan. Dengan adanya gambar desain ini diharapkan akan dapat membantu pihak kepanitiaan dalam proses pelaksanaan pembangunan, penyebaran informasi, hingga dapat menjadi bahan untuk pembuatan proposal dalam menggalang dana dari donatur pembangunan.