bluuebunny/crossref_metadata_2025 huggingface dataset:
Prior knowledge, cognitive characteristics and opportunity recognition
Authors: Hajizadeh Ali , Zali Mohammadreza
Published: February 2016

Purpose

– In order to answer why and how some individuals identify opportunities, the purpose of this paper is to offer a comprehensive framework of key effective factors that investigates the role of prior knowledge and cognitive characteristics of entrepreneurial alertness and learning in the entrepreneurial opportunities recognition process.

Design/methodology/approach

– First, the authors identified key effective factors and developed research hypotheses and conceptual model. Second, the authors considered research methodology including sampling and data collection, measurement model. The third section presents a report of the results from the analysis of the structural model and the hypotheses tests.

Findings

– The findings show that all the three factors had positive impact on opportunity recognition. It is also confirmed that prior knowledge has significant impact on entrepreneurial alertness and learning. Finally, the results demonstrate that both entrepreneurial alertness and learning partially mediated the relationship between prior knowledge and opportunity recognition.

Research limitations/implications

– Possible effects of other cognitive characteristics such as creativity and innovation can be considered in the model to increase accuracy of the findings. Also, comparative studies with the proposed framework in different industrial domains can be conducted in order to compare the possible differences concerning the role of the factors in opportunity recognition.

Practical implications

– By using this model, entrepreneurs will be able to identify and enhance the factors that influence opportunity recognition, thus honing this entrepreneurial ability. Also, this framework can be employed in the field of education to identify opportunity recognition problems in individuals and to foster entrepreneurs.

Originality/value

– This paper presents a new integrated model that would examine the impact of key effective factors of entrepreneurial opportunity recognition simultaneously while taking into account the interactions among them.
Human–wildlife conflict, benefit sharing and the survival of lions in pastoralist community‐based conservancies
Authors: Blackburn Sara , Hopcraft J. Grant C. , Ogutu Joseph O. , Matthiopoulos Jason , Frank Laurence
Published: February 2016

Like many wildlife populations across Africa, recent analyses indicate that African lions are declining rapidly outside of small fenced areas. Community conservancies – privately protected areas that engage community members in conservation – may potentially maintain wildlife populations in unfenced pastoralist regions, but their effectiveness in conserving large carnivores has been largely unknown until now.

We identify drivers of lion survival in community conservancies within the Masai Mara ecosystem, Kenya, applying mark–recapture analyses to continuous sight–resight surveys. We use the number of livestock and human settlements as proxies for potential human–lion conflict whilst controlling for environmental variables and lion socioecology.

Average lion densities within the Mara conservancies between 2008 and 2013 (11·87 lions 100 km−2) were 2·6 times higher than those previously reported in 2003. Survival rates varied amongst prides and were highest for lions utilizing central regions of conservancies.

The number of livestock settlements (bomas [corrals] and manyattas) that were not members of a conservancy, and that fell within a pride home‐range, had a large negative effect on female survival and was the most influential external predictor in models. These non‐conservancy settlements accounted for 37·2% of total observed variation in survival, whereas conservancy settlements, which benefit financially from wildlife through their membership, had no effect on lion survival.

Internal drivers of survival agreed with known ecology and social behaviour including age plus a negative effect of male takeovers on cub survival <6 months. Vegetation cover, prey availability and the density of grazing livestock within a pride's range did not explain patterns in lion survival.

Synthesis and applications. We show that lion densities have increased substantially within the Mara conservancies over the last decade and suggest that the creation of community conservancies has benefitted their survival. This suggests that lions can survive outside of fenced areas within pastoral regions if communities gain benefits from wildlife. We highlight the importance of expanding existing conservancies beyond their current geographical and political scope and forming buffer zones if wildlife ranges outside them. We suggest that changing attitudes to predators should be a key goal of community‐based conservancies. Further work is recommended to identify what specific aspects of conservancy membership promote lion survival.
Osmotic stress response in Acinetobacter baylyi: identification of a glycine–betaine biosynthesis pathway and regulation of osmoadaptive choline uptake and glycine–betaine synthesis through a choline‐responsive BetI repressor
Authors: Scholz Anica , Stahl Julia , de Berardinis Veronique , Müller Volker , Averhoff Beate
Published: February 2016

Acinetobacter baylyi, a ubiquitous soil bacterium, can cope with high salinity by uptake of choline as precursor of the compatible solute glycine betaine. Here, we report on the identification of a choline dehydrogenase (BetA) and a glycine betaine aldehyde dehydrogenase (BetB) mediating the oxidation of choline to glycine betaine. The betAB genes were found to form an operon together with the potential transcriptional regulator betI. The transcription of the betIBA operon and the two recently identified choline transporters was upregulated in response to choline and choline plus salt. The finding that the osmo‐independent transporter BetT1 undergoes a higher upregulation in response to choline alone than betT2 suggests that BetT1 does not primarily function in osmoadaptation. Electrophoretic mobility shift assays led to the conclusion that BetI mediates transcriptional regulation of both, the betIBA gene operon and the choline transporters. BetI was released from the DNA in response to choline which together with the transcriptional upregulation of the bet genes in the presence of choline suggests that BetI is a choline sensing transcriptional repressor.
Estimation in Closed Capture–Recapture Models when Covariates Are Missing at Random
Authors: Lee Shen-Ming , Hwang Wen-Han , de Dieu Tapsoba Jean
Published: February 2016

Individual covariates are commonly used in capture–recapture models as they can provide important information for population size estimation. However, in practice, one or more covariates may be missing at random for some individuals, which can lead to unreliable inference if records with missing data are treated as missing completely at random. We show that, in general, such a naive complete-case analysis in closed capture–recapture models with some covariates missing at random underestimates the population size. We develop methods for estimating regression parameters and population size using regression calibration, inverse probability weighting, and multiple imputation without any distributional assumptions about the covariates. We show that the inverse probability weighting and multiple imputation approaches are asymptotically equivalent. We present a simulation study to investigate the effects of missing covariates and to evaluate the performance of the proposed methods. We also illustrate an analysis using data on the bird species yellow-bellied prinia collected in Hong Kong.
Computer Use, Job Tasks and the Part‐Time Pay Penalty
Authors: Elsayed Ahmed , de Grip Andries , Fouarge Didier
Published: February 2016

Using data from the UK Skills Surveys 1997–2012, we show that the part‐time pay penalty (PTPP) for women within low‐ and medium‐skilled occupations has decreased significantly. The convergence in computer use and non‐routine job tasks between part‐time and full‐time workers explains a large share of the decrease in the PTPP. This convergence took place mainly within occupations, and was not driven by changes in occupational segregation between the two groups of workers. The lower PTPP is also related to changes in the returns to job tasks. Relative changes in the importance of and returns to computer use and job tasks together explain more than 50 per cent of the decrease in the PTPP.
Distinguishing clinical and radiological features of non‐traumatic convexal subarachnoid hemorrhage
Authors: Graff‐Radford J. , Fugate J. E. , Klaas J. , Flemming K. D. , Brown R. D. , Rabinstein A. A.
Published: February 2016

Background and purpose

The full spectrum of causes of convexal subarachnoid hemorrhage (cSAH) requires further investigation. Therefore, our objective was to describe the spectrum of clinical and imaging features of patients with non‐traumatic cSAH.

Methods

A retrospective observational study of consecutive patients with non‐traumatic cSAH was performed at a tertiary referral center. The underlying cause of cSAH was characterized and clinical and imaging features that predict a specific etiology were identified. The frequency of future cSAH or intracerebral hemorrhage (ICH) was determined.

Results

In all, 88 patients [median age 64 years (range 25–85)] with non‐traumatic cSAH were identified. The most common causes were reversible cerebral vasoconstriction syndrome (RCVS) (26, 29.5%), cerebral amyloid angiopathy (CAA) (23, 26.1%), indeterminate (14, 15.9%) and endocarditis (9, 10.2%). CAA patients commonly presented at an older age than RCVS patients (75 years versus 51 years, P < 0.0001). Thirteen patients (14.7%) had recurrent cSAH, and 12 patients (13.6%) had a subsequent ICH. However, the risk was high amongst those with CAA compared to those caused by RCVS, with recurrent cSAH in 39.1% and subsequent lobar ICH in 43.5% of CAA cases.

Conclusions

Our study demonstrates the clinical diversity of cSAH. Older age, sensorimotor dysfunction and stereotyped spells suggest CAA as the underlying cause. Younger age and thunderclap headache predict RCVS. Yet, various other causes also need to be considered in the differential diagnosis.
How can we harness quantitative genetic variation in crop root systems for agricultural improvement?
Authors: Topp Christopher N. , Bray Adam L. , Ellis Nathanael A. , Liu Zhengbin
Published: February 2016

Root systems are a black box obscuring a comprehensive understanding of plant function, from the ecosystem scale down to the individual. In particular, a lack of knowledge about the genetic mechanisms and environmental effects that condition root system growth hinders our ability to develop the next generation of crop plants for improved agricultural productivity and sustainability. We discuss how the methods and metrics we use to quantify root systems can affect our ability to understand them, how we can bridge knowledge gaps and accelerate the derivation of structure‐function relationships for roots, and why a detailed mechanistic understanding of root growth and function will be important for future agricultural gains.
Higher sleep variability is associated with poorer glycaemic control in patients with type 1 diabetes
Authors: Chontong Sasipas , Saetung Sunee , Reutrakul Sirimon
Published: February 2016

Sleep disturbances have been linked to insulin resistance and poor glycaemic control in patients with type 2 diabetes. However, the data are limited in type 1 diabetes. Recently, varying day‐to‐day sleep schedules, i.e. sleep variability, have been associated with adverse metabolic profile in healthy individuals. This study explored whether sleep variability affects glycaemic control and insulin requirement in type 1 diabetes. Forty‐one adult patients with type 1 diabetes wore an actigraphy for 5 nights. Standard deviation of sleep duration, efficiency and mid‐sleep time were sleep variability parameters. Sleep apnoea risk and self‐reported sleep quality were assessed by the Berlin questionnaire and Pittsburgh Sleep Quality Index. Haemoglobin A1c, diabetes complications and insulin regimen were obtained from medical records. After adjusting for neuropathic symptoms, sleep apnoea risk and poor self‐reported sleep quality, higher sleep variability was significantly associated with poorer glycaemic control (standard deviation of sleep duration, B = 0.100, P = 0.004; and standard deviation of mid‐sleep time, B = 0.068, P = 0.04). In addition, standard deviations of sleep duration and mid‐sleep time were highly correlated, suggesting that participants changed their sleep duration along with sleep timing. After adjusting for covariates, the standard deviation of sleep duration (P = 0.009) and standard deviation of mid‐sleep time (P = 0.012) were associated with higher insulin requirement. In summary, higher sleep variability, which likely reflects sleep deprivation alternating with sleep compensation along with shifts in their circadian timing, was associated with poorer glycaemic control and higher insulin requirement in patients with type 1 diabetes. Increased sleep regularity may improve metabolic control in type 1 diabetes.
Immunodominant Dengue Virus-Specific CD8
+
T Cell Responses Are Associated with a Memory PD-1
+
Phenotype
Authors: de Alwis Ruklanthi , Bangs Derek J. , Angelo Michael A. , Cerpas Cristhiam , Fernando Anira , Sidney John , Peters Bjoern , Gresh Lionel , Balmaseda Angel , de Silva Aruna D. , Harris Eva , Sette Alessandro , Weiskopf Daniela
Published: February 2016

Dengue disease is a large public health problem that mainly afflicts tropical and subtropical regions. Understanding of the correlates of protection against dengue virus (DENV) is poor and hinders the development of a successful human vaccine. The present study aims to define DENV-specific CD8
+
T cell responses in general and those of HLA alleles associated with dominant responses in particular. In human blood donors in Nicaragua, we observed a striking dominance of HLA B-restricted responses in general and of the allele B*35:01 in particular. Comparing these patterns to those in the general population of Sri Lanka, we found a strong correlation between restriction of the HLA allele and the breadth and magnitude of CD8
+
T cell responses, suggesting that HLA genes profoundly influence the nature of responses. The majority of gamma interferon (IFN-γ) responses were associated with effector memory phenotypes, which were also detected in non-B*35:01-expressing T cells. However, only the B*35:01 DENV-specific T cells were associated with marked expression of the programmed death 1 protein (PD-1). These cells did not coexpress other inhibitory receptors and were able to proliferate in response to DENV-specific stimulation. Thus, the expression of particular HLA class I alleles is a defining characteristic influencing the magnitude and breadth of CD8 responses, and a distinct, highly differentiated phenotype is specifically associated with dominant CD8
+
T cells. These results are of relevance for both vaccine design and the identification of robust correlates of protection in natural immunity.

IMPORTANCE
Dengue is an increasingly significant public health problem as its mosquito vectors spread over greater areas; no vaccines against the virus have yet been approved. An important step toward vaccine development is defining protective immune responses; toward that end, we here characterize the phenotype of the immunodominant T cell responses. These DENV-reactive T cells express high levels of the receptor programmed death 1 protein (PD-1), while those from disease-susceptible alleles do not. Not only does this represent a possible correlate of immunodominance, but it raises the hypothesis that PD-1 might be a regulator that prevents excessive damage while preserving antiviral function. Further, as this study employs distinct populations (Nicaraguan and Sri Lankan donors), we also confirmed that this pattern holds despite geographic and ethnic differences. This finding indicates that HLA type is the major determinant in shaping T cell responses.
Steak tartare endocarditis
Authors: Reid Michael J A , Shannon Evan Michael , Baxi Sanjiv M , Chin-Hong Peter
Published: February 2016

This report describes a case ofCampylobacter fetusprosthetic valve infective endocarditis and discusses the subsequent management. AlthoughC. fetushas a tropism for vascular endothelium, infective endocarditis has rarely been reported. In this patient, despite initial optimal antimicrobial therapy, valve replacement was ultimately required due to ongoing infectious emboli to the brain in the setting of evidence of vegetation enlargement on echocardiogram. The prosthetic valve was replaced, the patient completed a 6-week course of parenteral antibiotics after surgical intervention and he made a full recovery with no long-term neurological sequelae. This case highlights the fact that despite the relatively low prevalence ofC. fetusendocarditis, it is associated with a high degree of mortality and valve replacement is often indicated.
Pioglitazone therapy for HIV/HAART-associated lipodystrophy syndrome could increase subcutaneous fat mass in non-lipoatrophic but not in lipoatrophic regions
Authors: Okada Sadanori , Konishi Mitsuru , Ishii Hitoshi
Published: February 2016

Highly active antiretroviral therapy (HAART) is associated with multiple metabolic disorders, including lipodystrophy, dyslipidaemia and insulin resistance. HIV/HAART-associated lipodystrophy syndrome (HALS) is characterised by subcutaneous fat wasting, central fat accumulation and increased risk of diabetes. Thiazolidinediones are considered a promising treatment for HALS, because they improve insulin sensitivity and increase subcutaneous fat mass. In previous studies, pioglitazone increased overall fat mass in patients with HALS but whether fat distribution changes remains unclear. We describe a HALS patient with diabetes treated with pioglitazone. Prior to pioglitazone therapy, he had hollowed cheeks, loss of fat in the extremities and abdominal obesity. 18 months after starting pioglitazone and switching his HAART regimens, T1-weighted MRI showed obvious increases in the subcutaneous fat mass of the neck and upper trunk, but no changes in the cheeks and extremities. Pioglitazone therapy for HALS could increase subcutaneous fat mass in non-lipoatrophic but not in lipoatrophic regions.
Multidisciplinary care of a paediatric patient with Gradenigo's syndrome
Authors: Janjua Noor , Bajalan Mohammed , Potter Samantha , Whitney Andrea , Sipaul Fabian
Published: February 2016

A 10-year-old girl presented with signs and symptoms suggestive of Gradenigo's syndrome, a condition characterised by otorrhoea, diplopia due to abducens nerve palsy and pain in the region of the trigeminal nerve. This case examines the presentation of this condition, and the appropriate investigations. We also highlight the importance of the involvement of multiple specialities in discussing and devising a suitable management plan.
Rationale and design of Short-Term EXenatide therapy in Acute ischaemic Stroke (STEXAS): a randomised, open-label, parallel-group study
Authors: McGrath Rachel T , Hocking Samantha L , Priglinger Miriam , Day Susan , Herkes Geoffrey K , Krause Martin , Fulcher Gregory R
Published: February 2016

Introduction

Both hyperglycaemia and hypoglycaemia in acute ischaemic stroke (AIS) are associated with increased infarct size and worse functional outcomes. Thus, therapies that can maintain normoglycaemia during stroke are clinically important. Glucagon-like peptide 1 (GLP-1) analogues, including exenatide, are routinely used in the treatment of hyperglycaemia in type 2 diabetes, but data on the usefulness of this class of agents in the management of elevated glucose levels in AIS are limited. Owing to their glucose-dependent mechanism of action, GLP-1 analogues are associated with a low risk of hypoglycaemia, which may give them an advantage over intensive insulin therapy in the acute management of hyperglycaemia in this setting.

Methods and analysis

The Short-Term EXenatide therapy in Acute ischaemic Stroke study is a randomised, open-label, parallel-group pilot study designed to investigate the efficacy of exenatide at lowering blood glucose levels in patients with hyperglycaemia with AIS. A total of 30 patients presenting with AIS and blood glucose levels >10 mmol/L will be randomised to receive the standard therapy (intravenous insulin) or intravenous exenatide for up to 72 h. Outcomes including blood glucose levels within the target range (5–10 mmol/L), the incidence of hypoglycaemia and the feasibility of administering intravenous exenatide in this patient population will be assessed. A follow-up visit at 3 months will facilitate evaluation of neurological outcomes post-stroke.

Ethics and dissemination

This study has been approved by the local Institutional Review Board (Northern Sydney Local Health District Human Research Ethics Committee). The study results will be communicated via presentations at scientific conferences and through publication in peer-reviewed journals.

Conclusions

As GLP-1 analogues require elevated glucose levels to exert their insulin potentiating activity, the use of exenatide in the management of hyperglycaemia in AIS may reduce the incidence of hypoglycaemia, thereby conferring a benefit in morbidity and mortality for patients in the long term.

Trial registration number

ACTRN12614001189617.
Republished: Retained needle after cement injection during vertebral augmentation and its management strategy
Authors: Kosse Angelika , Nakhla Jonathan Pishoi , Yassari Reza , Abramowicz Apolonia Elisabeth , Brook Allan
Published: February 2016

A middle aged patient with multiple myeloma resulting in numerous pathological fractures underwent an L2, L3, and L5 vertebral cement augmentation for pain relief. After injection, the trocar at L2, the final level, could not be withdrawn despite several attempts of needle rotation, a second needle inserted to distract on, and rocking the needle on the pedicle. After a neurosurgical consultation, the patient was transferred to the operating room for open removal. As the needle protruded approximately 3 inches from the patient's back, the patient could not be positioned supine, and was anesthetized and intubated in the right semi-prone position prior to being placed prone on the operating room table. The needle was surgically exposed, cut off at the pedicular bone edge, and its free component was removed.
RESTING MECHANOMYOGRAPHIC AMPLITUDE FROM THE VASTUS LATERALIS MUSCLE IN DIFFERENT POSTURAL RESTING POSITIONS FOLLOWING AEROBIC EXERCISE
Authors: Wages Nathan P. , Beck Travis W. , Ye Xin , Carr Joshua C. , Miller Cody A.
Published: February 2016

Purpose: To evaluate the post-exercise time course for muscle relaxation and recovery following aerobic exercise in different postural resting positions between the dominant and non-dominant vastus lateralis muscles. Methods: Subjects exercised on an upright cycle ergometer, using only their dominate leg, for 2[Formula: see text]min at 30% VO2peak. Following this warm-up, subjects then cycled for 30[Formula: see text]min at 60% VO2peak. After the aerobic phase, subjects cooled down for 2[Formula: see text]min at 30% VO2peak. Resting mechanomyographic amplitude was measured prior to and following aerobic exercise. Results: There was an approximate [Formula: see text] and [Formula: see text] decrease (upright sitting position with the subject’s knee joint angle fixed at 180[Formula: see text]) and an approximate [Formula: see text] and [Formula: see text] decrease (upright sitting position with the subject’s knee joint angle fixed at 90[Formula: see text]) in normalized mechanomyographic amplitude after aerobic exercise for the dominant and non-dominate vastus lateralis muscles, respectfully. Conclusion: There appears to be a potential cross-over relaxation effect during the sitting postural positions, but not during the lying supine postural positions. Furthermore, it appears that the relaxation from the dominant vastus lateralis muscle potentially influenced the increased relaxation of the non-dominant vastus lateralis muscle.
Esophageal contractions in type 3 achalasia esophagus: simultaneous or peristaltic?
Authors: Kim Tae Ho , Patel Nirali , Ledgerwood-Lee Melissa , Mittal Ravinder K.
Published: February 2016

Absence of peristalsis and impaired relaxation of lower esophageal sphincter are the hallmarks of achalasia esophagus. Based on the pressurization patterns, achalasia has been subdivided into three subtypes. The goal of our study was to evaluate the esophageal contraction pattern and bolus clearance in type 3 achalasia esophagus. High-resolution manometry (HRM) recordings of all patients diagnosed with achalasia esophagus in our center between the years 2011 and 2013 were reviewed. Recordings of 36 patients with type 3 achalasia were analyzed for the characteristics of swallow-induced “simultaneous esophageal contraction.” The HRM impedance recordings of 14 additional patients with type 3 achalasia were analyzed for bolus clearance from the impedance recording. Finally, the HRM impedance along with intraluminal ultrasound imaging was conducted in six patients to further characterize the simultaneous esophageal contractions. Among 187 achalasia patients, 30 were type 1, 121 type 2, and 36 type 3. A total of 434 swallows evaluated in type 3 achalasia patients revealed that 95% of the swallow-induced contractions met criteria for simultaneous esophageal contraction, based on the onset of contraction. Interestingly, the peak and termination of the majority of simultaneous esophageal contractions were sequential. The HRM impedance revealed that 94% of the “simultaneous contractions” were associated with complete bolus clearance. Ultrasound image analysis revealed that baseline muscle thickness of patients in type 3 achalasia is larger than normal but the pattern of axial shortening is similar to that in normal subjects. The majority of esophageal contractions in type 3 achalasia are not true simultaneous contractions because the peak and termination of contraction are sequential and they are associated with complete bolus clearance.
MicroRNAs as novel therapeutic targets to treat kidney injury and fibrosis
Authors: Gomez Ivan G. , Nakagawa Naoki , Duffield Jeremy S.
Published: February 2016

MicroRNAs (miRs), a class of small noncoding RNAs that act as post-transcriptional regulators of gene expression, have attracted increasing attention as critical regulators of organogenesis, cancer, and disease. Interest has been spurred by development of a novel class of synthetic RNA oligonucleotides with excellent drug-like properties that hybridize to a specific miR, preventing its action. In kidney disease, a small number of miRs are dysregulated. These overlap with regulated miRs in nephrogenesis and kidney cancers. Several dysregulated miRs have been identified in fibrotic diseases of other organs, representing a “fibrotic signature,” and some of these fibrotic miRs contribute remarkably to the pathogenesis of kidney disease. Chronic kidney disease, affecting ∼10% of the population, leads to kidney failure, with few treatment options. Here, we will explore the pathological mechanism of miR-21, whose pre-eminent role in amplifying kidney disease and fibrosis by suppressing mitochondrial biogenesis and function is established. Evolving roles for miR-214, -199, -200, -155, -29, -223, and -126 in kidney disease will be discussed, and we will demonstrate how studying functions of distinct miRs has led to new mechanistic insights for kidney disease progression. Finally, the utility of anti-miR oligonucleotides as potential novel therapeutics to treat chronic disease will be highlighted.
Efficient Method for Calculating the Composite Stiffness of Parabolic Leaf Springs with Variable Stiffness for Vehicle Rear Suspension
Authors: Shi Wen-ku , Liu Cheng , Chen Zhi-yong , He Wei , Zu Qing-hua
Published: February 2016

The composite stiffness of parabolic leaf springs with variable stiffness is difficult to calculate using traditional integral equations. Numerical integration or FEA may be used but will require computer-aided software and long calculation times. An efficient method for calculating the composite stiffness of parabolic leaf springs with variable stiffness is developed and evaluated to reduce the complexity of calculation and shorten the calculation time. A simplified model for double-leaf springs with variable stiffness is built, and a composite stiffness calculation method for the model is derived using displacement superposition and material deformation continuity. The proposed method can be applied on triple-leaf and multileaf springs. The accuracy of the calculation method is verified by the rig test and FEA analysis. Finally, several parameters that should be considered during the design process of springs are discussed. The rig test and FEA analytical results indicate that the calculated results are acceptable. The proposed method can provide guidance for the design and production of parabolic leaf springs with variable stiffness. The composite stiffness of the leaf spring can be calculated quickly and accurately when the basic parameters of the leaf spring are known.
Determining the Critical Slip Surface of Three-Dimensional Soil Slopes from the Stress Fields Solved Using the Finite Element Method
Authors: Yang Yu-chuan , Xing Hui-ge , Yang Xing-guo , Zhou Jia-wen
Published: February 2016

The slope stability problem is an important issue for the safety of human beings and structures. The stability analysis of the three-dimensional (3D) slope is essential to prevent landslides, but the most important and difficult problem is how to determine the 3D critical slip surface with the minimum factor of safety in earth slopes. Basing on the slope stress field with the finite element method, a stability analysis method is proposed to determine the critical slip surface and the corresponding safety factor of 3D soil slopes. Spherical and ellipsoidal slip surfaces are considered through the analysis. The moment equilibrium is used to compute the safety factor combined with the Mohr-Coulomb criteria and the limit equilibrium principle. Some assumptions are introduced to reduce the search range of center points and the radius of spheres or ellipsoids. The proposed method is validated by a classical 3D benchmark soil slope. Simulated results indicate that the safety factor of the benchmark slope is 2.14 using the spherical slip surface and 2.19 using the ellipsoidal slip surface, which is close to the results of previous methods. The simulated results indicate that the proposed method can be used for the stability analysis of a 3D soil slope.
Sensor Location Problem for Network Traffic Flow Derivation Based on Turning Ratios at Intersection
Authors: Shao Minhua , Sun Lijun , Shao Xianzhi
Published: February 2016

The sensor location problem (SLP) discussed in this paper is to find the minimum number and optimum locations of the flow counting points in the road network so that the traffic flows over the whole network can be inferred uniquely. Flow conservation system at intersections is formulated firstly using the turning ratios as the prior information. Then the coefficient matrix of the flow conservation system is proved to be nonsingular. Based on that, the minimal number of counting points is determined to be the total number of exclusive incoming roads and dummy roads, which are added to the network to represent the trips generated on real roads. So the task of SLP model based on turning ratios is just to determine the optimal sensor locations. The following analysis in this paper shows that placing sensors on all the exclusive incoming roads and dummy roads can always generate a unique network flow vector for any network topology. After that, a detection set composed of only real roads is proven to exist from the view of feasibility in reality. Finally, considering the roads importance and cost of the sensors, a weighted SLP model is formulated to find the optimal detection set. The greedy algorithm is proven to be able to provide the optimal solution for the proposed weighted SLP model.
IRE1α Signaling Pathways Involved in Mammalian Cell Fate Determination
Authors: Wu Jie , He Guang-Ting , Zhang Wei-Jin , Xu Jing , Huang Qiao-Bing
Published: February 2016

A diverse array of cellular stresses can lead to accumulation of misfolded or unfolded proteins in endoplasmic reticulum (ER), which subsequently elicits ER stress. Inositol-requiring enzyme 1α (IRE1α) is the most sensitive of the three unfolded protein response (UPR) branches which are triggered to cope with ER stress in mammalian cells. IRE1α signaling is quite context-specific on account of many adaptor and modulator proteins that directly interact with it, including heat shock proteins (HSPs), RING finger protein 13 (RNF13), poly (ADP-ribose) polymerase 16 (PARP16), Bax/Bak, and Bax inhibitor-1 (BI-1). The activated IRE1α triggers different downstream pathways depending on the UPRosome formed by distinct modulator proteins. At the initial phase of ER stress, IRE1α-XBP1 axis functions as an adaptive response. While ER stress sustains or intensifies, signals shift to apoptotic responses. Furthermore, IRE1α signaling can be exploited to the development of a wide range of prevalent human diseases, with cancer the most characterized. Here we provide an overview of recent insights into the complex IRE1α signaling network which makes IRE1α an intriguing cell fate switch. Besides, the functional relevance is presented since IRE1α activation also participates in some other physiological processes beyond protein-folding status.
Continued Growth of the Central Nervous System without Mandatory Addition of Neurons in the Nile Crocodile (Crocodylus niloticus)
Authors: Ngwenya Ayanda , Patzke Nina , Manger Paul R. , Herculano-Houzel Suzana
Published: February 2016

It is generally believed that animals with larger bodies require larger brains, composed of more neurons. Across mammalian species, there is a correlation between body mass and the number of brain neurons, albeit with low allometric exponents. If larger bodies imperatively require more neurons to operate them, then such an increase in the number of neurons should be detected across individuals of a continuously growing species, such as the Nile crocodile. In the current study we use the isotropic fractionator method of cell counting to determine how the number of neurons and non-neurons in 6 specific brain regions and the spinal cord change with increasing body mass in the Nile crocodile. The central nervous system (CNS) structures examined all increase in mass as a function of body mass, with allometric exponents of around 0.2, except for the spinal cord, which increases with an exponent of 0.6. We find that numbers of non-neurons increase slowly, but significantly, in all CNS structures, scaling as a function of body mass with exponents ranging between 0.1 and 0.3. In contrast, numbers of neurons scale with body mass in the spinal cord, olfactory bulb, cerebellum and telencephalon, with exponents of between 0.08 and 0.20, but not in the brainstem and diencephalon, the brain structures that receive inputs and send outputs to the growing body. Densities of both neurons and non-neurons decrease with increasing body mass. These results indicate that increasing body mass with growth in the Nile crocodile is associated with a general addition of non-neurons and increasing cell size throughout CNS structures, but is only associated with an addition of neurons in some structures (and at very small rates) and not in those brain structures directly connected to the body. Larger bodies thus do not imperatively require more neurons to operate them.
Previous Vaccination and Age are More Important Predictors of Immune Response to Influenza Vaccine than Inflammation and Iron Status in Dialysis Patients
Authors: Eiselt Jaromír , Kielberger Lukáš , Rajdl Daniel , Racek Jaroslav , Pazdiora Petr , Malánová Lada
Published: February 2016

Background/Aims: The immune response to influenza vaccine may be influenced by many factors, e.g. age, comorbidities or inflammation, and iron status. Methods: We studied the vaccine-induced production of hemagglutination-inhibition antibodies (HI) in 133 hemodialysis patients (HD) and 40 controls. To identify variables associated with the immune response, uni- and multivariate regression analyses were performed with seroconversion in HI titers as a dependent variable, with demographics, comorbidities, previous vaccination, inflammation, and iron status as independent variables. Results: Seroconversion rates were lower in HD than in controls [43% versus 73% (H1N1 strain; p < 0.05); 43% versus 53% (H3N2; P=NS); 36% versus 62% (B; p < 0.05)]. In both HD and control groups, the predictors of the inferior HI production were pre-vaccination seroprotection, vaccination in the previous season, and old age. We did not find associations between seroconversion rates and inflammation and iron status in the studied populations. This was also true for a subanalysis of patients without pre-vaccination seroprotection. Conclusion: The influenza vaccine-induced antibody production was lower in HD than in controls and was independent of inflammation and iron status in both groups. Besides dependence on dialysis, the variables associated with inferior seroconversion rates included pre-vaccination seroprotection, previous vaccination, and old age.
A Combined Cognitive Stimulation and Physical Exercise Programme (MINDVital) in Early Dementia: Differential Effects on Single- and Dual-Task Gait Performance
Authors: Tay Laura , Lim Wee Shiong , Chan Mark , Ali Noorhazlina , Chong Mei Sian
Published: February 2016

Background: Gait disorders are common in early dementia, with particularly pronounced dual-task deficits, contributing to the increased fall risk and mobility decline associated with cognitive impairment. Objective: This study examines the effects of a combined cognitive stimulation and physical exercise programme (MINDVital) on gait performance under single- and dual-task conditions in older adults with mild dementia. Methods: Thirty-nine patients with early dementia participated in a multi-disciplinary rehabilitation programme comprising both physical exercise and cognitive stimulation. The programme was conducted in 8-week cycles with participants attending once weekly, and all participants completed 2 successive cycles. Cognitive, functional performance and behavioural symptoms were assessed at baseline and at the end of each 8-week cycle. Gait speed was examined under both single- (Timed Up and Go and 6-metre walk tests) and dual-task (animal category and serial counting) conditions. A random effects model was performed for the independent effect of MINDVital on the primary outcome variable of gait speed under dual-task conditions. Results: The mean age of patients enroled in the rehabilitation programme was 79 ± 6.2 years; 25 (64.1%) had a diagnosis of Alzheimer's dementia, and 26 (66.7%) were receiving a cognitive enhancer therapy. There was a significant improvement in cognitive performance [random effects coefficient (standard error) = 0.90 (0.31), p = 0.003] and gait speed under both dual-task situations [animal category: random effects coefficient = 0.04 (0.02), p = 0.039; serial counting: random effects coefficient = 0.05 (0.02), p = 0.013], with reduced dual-task cost for gait speed [serial counting: random effects coefficient = -4.05 (2.35), p = 0.086] following successive MINDVital cycles. No significant improvement in single-task gait speed was observed. Improved cognitive performance over time was a significant determinant of changes in dual-task gait speed [random effects coefficients = 0.01 (0.005), p = 0.048, and 0.02 (0.005), p = 0.003 for category fluency and counting backwards, respectively]. Conclusion: A combined physical and cognitive rehabilitation programme leads to significant improvements in dual-task walking in early dementia, which may be contributed by improvement in cognitive performance, as single-task gait performance remained stable.
Seal Hunting in the Arctic States. An Analysis of Legislative Frameworks, Incentives and Histories
Authors: Sellheim Nikolas
Published: February 2016

In the Arctic, where there are seals there are seal hunters. And it is the Arctic states which have been hunting seals for generations. But contrary to other marine mammals, no comprehensive Arctic treaty exists which regulates the hunt for seals. Instead, each Arctic state has developed its own legislative framework for seal hunting. This article screens the current seal hunting legislation in the Arctic states and provides an assessment of the different regimes with regard to animal welfare, professionalism of the hunters and environmental considerations. While there are differences in the set-up of the respective legislation this can be explained by different historical geneses and underlying incentives. Historical developments and the purposes of the seal hunts are therefore discussed in light of current legislation. Lastly, this paper suggests that although a comprehensive sealing treaty in the Arctic is not feasible, close regional cooperation is a crucial element in seal management in the Arctic.
The Construction of a Three-Dimensional Antenna Gain Matrix and Its Impact on Retrieving Sea Surface Mean Square Slope Based on Aircraft Wave Spectrometer Data
Authors: Li Xiuzhong , He Yijun , Zhang Biao , Fan Chenqing
Published: February 2016

In this study, a rotating frequency-modulated continuous wave (FMCW) radar is installed on an aircraft to retrieve the sea wave spectra. Because the aircraft attitude angles produce the incorrect antenna gain used in the radar equation, the incorrect normalized radar cross section (NRCS) of the sea surface will be acquired. To eliminate the effect of the angles, a three-dimensional matrix of the radar antenna gain is constructed by means of coordinate transformation and interpolation, based on a large set of configurations of the aircraft attitude angles (roll, pitch, etc.). With the application of the matrix, the NRCS of the sea surface is corrected and the calculating time is reduced. Then the sea surface mean square slope (MSS) is obtained from the echoes of the airborne wave spectrometer. Considering a weak periodicity of MSS due to low sea state, four images are presented to show the variation of the MSS after aircraft attitude angle correction. The results indicate that the accurate incidence angle of the antenna beam center is critical for retrieving the sea surface MSS, and that the magnitude of the MSS from three cycles of radar echoes can be changed by as much as 40% within 5° of the attitude angles. Furthermore, the MSS becomes more periodic and regular after correction.
Religion, Autonomy, and the Priority of Place in Mexico’s Maya Highlands
Authors: Chojnacki Ruth J.
Published: February 2016

The irruption of Mexico’s highland Maya on the world stage with the 1994 New Year’s Day uprising by the Zapatista Army of National Liberation generated a torrent of publications. Relatively neglected in this literature is the deconstruction of costumbre (ancestral Maya tradition) by Maya youth dislocated by Mexico’s early-1980s economic collapse. In one exemplary Tzotzil Maya pueblo, the acquisition of biblical literacy and the cognitive skills it entails in Catholic Church–sponsored courses oriented to liberation theology propelled a generational religious revolt. The ensuing reclamation of ancestral territory from ladino ranchers upended colonial relations, enabling indigenous peasants in this and other highland Maya communities to institute autonomous modes of production. Driven by a dialectic of religious ritual and agricultural labor, this assertion of Maya agency attests to the salience of religion and the priority of place as indispensable resources for indigenous socioeconomic autonomy confronting neoliberal assault.

La irrupción en el escenario mundial de los maya del altiplano mexicano con el levantamiento de Año Nuevo 1994 por el Ejército Zapatista de Liberación Nacional generó un torrente de publicaciones. Relativamente ignorada en esta literatura es la deconstrucción de costumbre (tradición maya ancestral) por la juventud maya desplazada por el colapso económico a principios de los ochenta en México. En un pueblo tzotzil maya ejemplar, la adquisición de cultura bíblica y las aptitudes cognitivas que implica en los cursos auspiciados por la Iglesia Católica Romana orientados a la teología de la liberación impulsó una rebelión religiosa generacional. La consiguiente recuperación de territorio ancestral de hacendados ladinos turbó las relaciones coloniales, permitiendo a los campesinos indígenas en esta y otras comunidades maya del altiplano establecer modos de producción autónomos. Motivado por una dialéctica de ritual religioso y trabajo agrícola, esta reivindicación de agencia maya confirma la relevancia de la religión y la primacía del lugar como recursos indispensables para una autonomía socioeconómica indígena al enfrentar la arremetida neoliberal.
Optimal diagnostics of residual stenosis after lysis
Authors: Hagley Daniel , Saha Prakash , Black Stephen
Published: February 2016

The treatment of acute deep vein thrombosis has developed significantly over the past few years, and catheter-directed thrombolysis is now widely accepted. Controversy still exists over the decision to treat residual or underlying lesions with a venous stent. Magnetic resonance techniques have evolved considerably, which together with intravenous ultrasound can provide a detailed assessment of the deep venous system. Nevertheless, there is still no single perfect imaging modality that can identify a functional stenosis in the venous system. The decision to proceed to stent placement following lysis is multifactorial, reliant on the use of a number of imaging modalities in combination but most importantly good clinical acumen and experience.
Should catheter-directed thrombolysis be monitored?
Authors: Bækgaard Niels , Klitfod Lotte , Jørgensen Maja
Published: February 2016

Catheter-directed thrombolysis for deep venous thrombosis is considered the basic treatment modality for intrathrombus removal. This method is preferably used in patients with iliofemoral deep venous thrombosis due to poor spontaneous recanalization in this segment, especially on the left side. The method was published almost 25 years ago and has gained ground in the treatment because of poor results from systemic thrombolysis and because of the possibility of stenting any underlying iliac obstruction during the procedure. However, the publications of catheter-directed thrombolysis reveal a great heterogeneity concerning catheter-directed thrombolysis technique and the lack of high quality evidence about monitoring as a tool to minimize the risk of bleeding and pulmonary embolism. Strict inclusion and exclusion criteria, correct composition and infusion of thrombolysis agent, imaging thrombus clearance during catheter-directed thrombolysis, ensuring flow enhancement during the bedridden situation, careful evaluation of indication for stenting based on imaging, and sufficient conversion to anticoagulation treatment following catheter-directed thrombolysis are essential. The aim of this paper is to discuss different treatment aspects of catheter-directed thrombolysis for iliofemoral thrombosis and to suggest a monitoring model for future treatment.