bluuebunny/crossref_metadata_2025 huggingface dataset:
The spatio-temporal expression analysis of parathyroid hormone like hormone gene provides a new insight for bone growth of the antler tip tissue in sika deer
Authors: Xing Haihua , Han Ruobing , Wang Qianghui , Sun Zihui , Li Heping
Published: February 2024

Objective: Parathyroid hormone like hormone (PTHLH), as an essential factor for bone growth, is involved in a variety of physiological processes. The aim of this study was to explore the role of PTHLH gene in the growth of antlers.Methods: The coding sequence (CDS) of PTHLH gene cDNA was obtained by cloning in sika deer (Cervus nippon), and the bioinformatics was analyzed. The quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze the differences expression of PTHLH mRNA in different tissues of the antler tip at different growth periods (early period, EP; middle period, MP; late period, LP).Results: The CDS of PTHLH gene was 534 bp in length and encoded 177 amino acids. Predictive analysis results revealed that the PTHLH protein was a hydrophilic protein without transmembrane structure, with its secondary structure consisting mainly of random coil. The PTHLH protein of sika deer had the identity of 98.31%, 96.82%, 96.05%, and 94.92% with Cervus canadensis, Bos mutus, Oryx dammah and Budorcas taxicolor, which were highly conserved among the artiodactyls. The qRT-PCR results showed that PTHLH mRNA had a unique spatio-temporal expression pattern in antlers. In the dermis, precartilage, and cartilage tissues, the expression of PTHLH mRNA was extremely significantly higher in MP than in EP, LP (p<0.01). In the mesenchyme tissue, the expression of PTHLH mRNA in MP was significantly higher than that of EP (p<0.05), but extremely significantly lower than that of LP (p<0.01). The expression of PTHLH mRNA in antler tip tissues at all growth periods had approximately the same trend, that is, from distal to basal, it was first downregulated from the dermis to the mesenchyme and then continuously up-regulated to the cartilage tissue.Conclusion: PTHLH gene may promote the rapid growth of antler mainly through its extensive regulatory effect on the antler tip tissue.
Comparison of miR-106b, miR-191, and miR-30d expression dynamics in milk with regard to its composition in Holstein and Ayrshire cows
Authors: Pozovnikova Marina V. , Leibova Viktoria B. , Tulinova Olga V. , Romanova Elena A. , Dysin Artem P. , Dementieva Natalia V. , Azovtseva Anastasiia I. , Sedykh Sergey E.
Published: February 2024

Objective: Milk composition varies considerably and depends on paratypical, genetic, and epigenetic factors. MiRNAs belong to the class of small non-coding RNAs; they are one of the key tools of epigenetic control because of their ability to regulate gene expression at the post-transcriptional level. We compared the relative expression levels of miR-106b, miR-191, and miR-30d in milk to demonstrate the relationship between the content of these miRNAs with protein and fat components of milk in Holstein and Ayrshire cattle.Methods: Milk fat, protein, and casein contents were determined in the obtained samples, as well as the content of the main fatty acids (g/100 g milk), including: saturated acids, such as myristic (C14:0), palmitic (C16:0), and stearic (C18:0) acids; monounsaturated acids, including oleic (C18:1) acid; as well as long-, medium- and short-chain, polyunsaturated, and trans fatty acids. Real-time stem-loop one-tube reverse transcription polymerase chain reaction with TaqMan probes was used to measure the miRNA expression levels.Results: The miRNA expression levels in milk samples were found to be decreased in the first two months in Holstein breed, and in the first four months in Ayrshire breed. Correlation analysis did not reveal any dependence between changes in the expression level of miRNA and milk fat content, but showed a multidirectional relationship with individual milk fatty acids. Positive associations between the expression levels of miR-106b and miR-30d and protein and casein content were found in the Ayrshire breed. Receiver operating characteristic curve analysis showed that miR-106b and miR-30d expression levels can cause changes in fatty acid and protein composition of milk in Ayrshire cows, whereas miR-106b expression level determines the fatty acid composition in Holsteins.Conclusion: The data obtained in this study showed that miR-106b, miR-191, and miR-30d expression levels in milk samples have peculiarities associated with breed affiliation and the lactation period.
Application of near-infrared spectroscopy for hay evaluation at different degrees of sample preparation
Authors: Jeong Eun Chan , Han Kun Jun , Ahmadi Farhad , Li Yan Fen , Wang Li Li , Yu Young Sang , Kim Jong Geun
Published: February 2024

Objective: A study was conducted to quantify the performance differences of the nearinfrared spectroscopy (NIRS) calibration models developed with different degrees of hay sample preparations.Methods: A total of 227 imported alfalfa (Medicago sativa L.) and another 360 imported timothy (Phleum pratense L.) hay samples were used to develop calibration models for nutrient value parameters such as moisture, neutral detergent fiber, acid detergent fiber, crude protein, and in vitro dry matter digestibility. Spectral data of hay samples prepared by milling into 1-mm particle size or unground were separately regressed against the wet chemistry results of the abovementioned parameters.Results: The performance of the developed NIRS calibration models was evaluated based on R2, standard error, and ratio percentage deviation (RPD). The models developed with ground hay were more robust and accurate than those with unground hay based on calibration model performance indexes such as R2 (coefficient of determination), standard error, and RPD. Although the R2 of calibration models was mainly greater than 0.90 across the feed value indexes, the R2 of cross-validations was much lower. The R2 of cross-validation varies depending on feed value indexes, which ranged from 0.61 to 0.81 in alfalfa, and from 0.62 to 0.95 in timothy. Estimation of feed values in imported hay can be achievable by the calibrated NIRS. However, the NIRS calibration models must be improved by including a broader range of imported hay samples in the modeling.Conclusion: Although the analysis accuracy of NIRS was substantially higher when calibration models were developed with ground samples, less sample preparation will be more advantageous for achieving rapid delivery of hay sample analysis results. Therefore, further research warrants investigating the level of sample preparations compromising analysis accuracy by NIRS.
Edupreneurship : Pemanfaatan Video Pembelajaran pada Platfom Youtube
Authors: Nada Qothrotun , Nuriadin Ishaq
Published: February 2024

Edupreneur ditekankan pada usaha kreatif atau inovatif yang dilakukan oleh sekolah untuk memperoleh prestasi dan menambah income. Melihat realita saat ini, penggunaan media sosial sudah tidak asing di kalangan masyarakat. Salah satunya adalah youtube. Tentu sebagai pendidik diharapkan dapat menyebarkan kebaikan, sehingga sudah selayaknya jika pendidik mewarnai platform youtube dengan konten-konten yang bermanfaat. Tujuan dari penelitian ini adalah untuk menganalisis potensi video pembelajaran di youtube sebagai edupreneur bidang pendidikan. Untuk mendapatkan penghasilan di platform youtube, content creator harus memiliki banyak subscriber dan rutin mengunggah video. Top 5 Youtube Channel Indonesia didominasi dari kategori entertain sedangkan yang berkategori pendidikan berada peringkat ke 11 di Indonesia. Peluang para content creator di bidang pendidikan masih cukup besar dan menjadi tantangan tersendiri untuk membuat video pembelajaran yang menarik dan rutin sehingga para views lebih tertarik untuk menonton video di bidang pendidikan.

Abstract

Edupreneurs are emphasized on creative or innovative efforts made by schools to gain achievements and increase income. Seeing the current reality, the use of social media is no stranger to the public. One of them is youtube. Of course, as educators, they are expected to spread kindness, so it is appropriate for educators to color the YouTube platform with useful content. The purpose of this study was to analyze the potential of learning videos on YouTube as educators in the field of education. To earn on the YouTube platform, content creators must have a lot of subscribers and regularly upload videos. The Top 5 Youtube Channels in Indonesia are dominated by the entertainment category, while those in the education category are ranked 11th in Indonesia. The opportunity for content creators in the field of education is still quite large and becomes a challenge in itself to make interesting and routine learning videos so that viewers are more interested in watching videos in the field of education.
Use of interrupted time-series analyses in evaluating health economic outcomes following implementation of multilayer water-tight wound closure in a primary total joint arthroplasty population
Authors: Tan Ziyu , Tomaszewski Joerg , Chen Brian Po-Han , Gunja Najmuddin J , Etter Katherine
Published: February 2024

Aim:
Total joint arthroplasty (TJA) with multi-layer, watertight closure (MLWC) using knotless barbed suture and 2-octyl cyanoacrylate plus polymer mesh tape was compared with conventional closure (CC) using Vicryl™ sutures and staples.
Patients & methods:
Electronic medical records of patients undergoing TJA (1574: total knee arthroplasty; 580: total hip arthroplasty; 13: unknown) from a single surgeon at a US hospital (CC 2011 to 2013; MLWC 2015 to 2020) were reviewed. Outcomes were length of stay (LOS), discharge to skilled nursing facility (SNF), 90-day surgical site infection (SSI) and 90-day readmission. Logistic regression controlled for baseline characteristics. Adjusted interrupted time series (ITS) analyses accounted for decreasing trends in LOS and SNF discharge over time.
Results:
Among 2167 TJA cases (mean [standard deviation] age 66.0 [9.7] years, 53.3% female), 906 received CC and 1261 received MLWC. Bivariate analysis showed no statistically significant differences in 90-day SSI rates; however, MLWC patients had 60% lower 90-day readmission rates (1.5 vs 3.8%, p < 0.05), 44% lower LOS (1.4 vs 2.5 days, p < 0.05) and 40% lower discharge rates to a skilled care facility (8.5 vs 14.1%, p < 0.05). Multivariable analyses showed CC patients were 2.45-times more likely to be readmitted within 90 days, 1.88-times more likely to be discharged to SNF and had 1.67-times longer LOS compared with MLWC. ITS analyses showed a sharp decline in LOS (0.9 days) and discharge to SNF (5.6% incidence) after implementation of MLWC, followed by no further changes for the remainder of the study period.
Conclusion:
MLWC was associated with ≥40% reduction in 90-day readmission, LOS and SNF discharge compared with TJA CC. LOS and discharge rate to SNF declined sharply after the implementation of MLWC.
Development of Creep and Mechanical Properties for SMAW Cr-Mo-X Steel Welds
Authors: Bae Sanghyun , Kim Yongchul , Liu Stephen
Published: February 2024

This research describes the development of new welding materials with high strength and high heat resistance for Cr-Mo-X type steels. Through thermodynamic simulation, the newly designed welding electrode had excellent mechanical properties, especially in high temperature tensile testing at 600℃ with 393.2 MPa tensile strength, 385.3 MPa yield strength and 23.5% elongation. Refinement of second phase particles were key to the success of the newly designed electrodes. Presence of M23C6 is noticeable in the new electrode welds which contributed to the high temperature strength and creep properties. Compared to conventional products, it was confirmed that the amount of M23C6 precipitates, measured in area fraction, increased substantially, from 5.9 to 11.9%. Z-phase, known to degrade weld mechanical properties, was reduced through adjusting chemical composition of the experimental welds. The reduction in Z-phase precipitates improved the brittle fracture resistance.
Pertanggung Jawaban Pihak Dokter kepada Pihak Keluarga Akibat dari Pencurian Organ Tubuh Dalam Autopsi
Authors: Putri Setiawan Sesicha
Published: February 2024

Pencurian organ tubuh dalam autopsi merupakan fenomena yang mengguncang kepercayaan masyarakat terhadap sistem kesehatan dan otoritas medis. Penelitian ini bertujuan untuk menganalisis pertanggungjawaban pihak dokter kepada pihak keluarga akibat dari pencurian organ tubuh dalam autopsi. Dengan menggunakan pendekatan yuridis normatif, penelitian ini mengeksplorasi aspek-aspek hukum yang terkait dengan pertanggungjawaban dokter dalam kasus semacam ini. Temuan penelitian menunjukkan bahwa dokter memiliki tanggung jawab profesional dan hukum untuk melindungi pasien serta keluarganya. Pertanggungjawaban dokter dapat berupa pertanggungjawaban perdata, yang meliputi ganti rugi atas kerugian yang dialami keluarga korban, dan pertanggungjawaban pidana, di mana dokter dapat dipenjarakan dan didenda sesuai dengan hukum yang berlaku. Upaya pencegahan dan penanggulangan pencurian organ tubuh dalam autopsi juga dibahas sebagai langkah-langkah penting untuk memastikan kejadian serupa tidak terulang kembali. Dengan pemahaman yang lebih baik tentang pertanggungjawaban dokter dan implikasinya terhadap pihak keluarga pasien, diharapkan perlindungan terhadap hak-hak pasien dan keluarganya dapat diperkuat, serta praktik medis di Indonesia tetap berada dalam batas-batas etika dan hukum yang benar.
Kekurangan Energi Kronik, Pengetahuan, Asupan Makanan dengan Stunting: Cross-Sectional Study
Authors: Manggabarani Saskiyanto , Tanuwijaya Rani Rahmasari , Said Irfan
Published: February 2024

Anak umur periode 2 tahun termasuk periode kritis dan masa emas dalam pertumbuhan dan perkembangan otak yang optimal. Malnutrisi yang terjadi pada anak usia ini akan menyebabkan masalah gizi seperti obesitas dan stunting. Angka kejadi stunting dan obesitas pada anak setiap tahunya meningkat yang disebabkan oleh beberapa pemicu utama termasuk pengetahuan pengasuh, sosial ekonomi serta asupan makan yang tidak sesuai dengan kebutuhan. Tujuan penelitian untuk mengetahui tingkat signifikansi kekurangan energi kronik, pengetahuan, asupan dengan stunting baduta. Metode penelitian menggunakan analisis kuantitatif dengan teknik survey serta desain cross sectional study. Sampel diseleksi dengan Teknik purposive sampling sebanyak 185 baduta yang telah memenuhi kiteria tidak menderita penyakit infeksi, umur 6-24 bulan, tidak lahir prmeatur, berat bayi lahir rendah, dan pangasuh bersedia untuk di wawancara. Data diperoleh menggunakan metode wawancara dengan kuesioner, formular food recall, timbangan digital, microtoise dan LILA. Analis data menggunakan uji korelasi dan determinasi (R2) dengan tingkat signifikansi nila p <0,05. Hasil ditemukan bahwa kekuerangan energi kronik, pengetahuan, dan asupan makanan diperoleh ada hubungan yang signifikan terhadap kejadian stunting dengan nilai p-value <0,05. Semakin tinggi pengetahuan ibu dan asupan makan anak akan seiring dengan meningkatkatnya status gizi juga namun sebaliknya status KEK ibu semakin meningkat tidak meyebakan pengkatan status gizi baduta.
Ekgmowechashala (Mammalia, ?Primates) from the Gulf Coastal Plain
Authors: Albright L. Barry
Published: February 2024

A single, small, water-worn tooth from the “middle” Arikareean Toledo Bend Local Fauna of the Gulf Coastal Plain closely resembles the lower fourth premolar of the questionable primate Ekgmowechashala. The only known species of the genus, Ekgmowechashala philotau Macdonald (1963), was originally recovered from the early Arikareean Sharps Formation of South Dakota, but is also known from similar aged strata of the John Day Formation, Oregon. Although the Toledo Bend specimen differs somewhat in morphology from the p4 of E. philotau, a new species is not named in this report because of such limited material and because the specimen is incomplete. Unfortunately, the specimen does not provide information that helps clarify current arguments regarding the affinities of Ekgmowechashala with primates or plagiomenids. It does, however, provide (1) a temporal range extension for the genus to the early late Arikareean, or about four million years younger than previously known, and (2) a geographic extension east and considerably south of its prior distribution. If Ekgmowechashala is ultimately determined to belong to the Primates, then the Toledo Bend species would become the last known North American representative of the order.
Population ecology of the snapping turtle (Chelydra serpentina osceola) in a northern Florida river
Authors: Johnston Gerald R. , Suarez Eric , Mitchell Joseph C. , Shemitz Georgia A. , Butt Peter L. , Kaunert Matthew
Published: February 2024

Snapping turtles (Chelydra serpentina) occur in nearly every type of freshwater habitat in North America east of the Rocky Mountains, but little is known about the ecology of populations in the southern part of their range, as well as those in lotic habitats. We conducted a mark-recapture study of the Florida snapping turtle (C. s. osceola) in the Santa Fe River in northern Florida between August 2005 and November 2010. Ninety-six percent of all captures occurred within a 9 km section of the river that receives direct input from 21 artesian springs. Within this “high density spring area,” population density and biomass of adults were 2.7 turtles/ha and 24.9 kg/ha, respectively. The total sample (n = 113 turtles) consisted of 14.2% immature individuals, 45.1% adult females, and 40.7% adult males. Adult sex ratio was 1:1. Juveniles occupied spring and spring run habitats disproportionally to the river habitat. Adult males (straight midline carapace length [CL] 243–439 mm, mean = 360 mm) are the largest known in Florida, and adult females (CL 257–380 mm, mean = 325 mm) are similar in size to the largest known conspecifics in Nebraska and South Dakota. The large body sizes in our population are inconsistent with previous studies that indicate a positive relationship between body size and latitude in this species, emphasizing the importance of habitat type in influencing demography. Large body sizes in the Santa Fe River may be related to the thermal/food resources provided by artesian springs, the physical environment of the riverine habitat, or coexistence with alligator snapping turtles (Macrochelys temminckii).
New Leontiniids (Class Mammalia, Order Notoungulata, Family Leontiniidae) from the Salla Beds of Bolivia (Deseadan, Late Oligocene)
Authors: Shockey Bruce J.
Published: February 2024

A revised diagnosis of the Leontiniidae (Class Mammalia, Order Notoungulata) is provided and leontiniids of the Deseadan South American Land Mammal "age" (SALMA; late Oligocene) are summarized. Two new species of leontinids from the Deseadan Salla Beds of Bolivia are described and placed within the new genus, Anayatherium; the smaller A. ekecoa and a much larger A. fortis. A phylogenetic analysis suggests that these species are closely related to the derived Patagonian genera Ancylocoelus and Colpodon, with the loss of the canine serving as a putative synapomorphy uniting these taxa. Although leontiniids are the most frequently encountered taxa at many other Deseadan localities, they are exceedingly rare at Salla. This scarcity, the scarcity of other ungulates with low crowned cheek teeth and the heavy tooth wear of a relatively young individual of A. ekecoa suggest that ungulates with low crowned teeth were at a selective disadvantage at Salla.
Carnivora from the Late Miocene Love Bone Bed of Florida
Authors: Baskin Jon A.
Published: February 2024

Eleven genera and twelve species of Carnivora are known from the late Miocene Love Bone Bed Local Fauna, Alachua County, Florida. Taxa from there described in detail for the first time include the canid cf. Urocyon sp., the hemicyonine ursid cf. Plithocyon sp., and the mustelids Leptarctus webbi n. sp., Hoplictis sp., and ?Sthenictis near ?S. lacota. Postcrania of the nimravid Barbourofelis indicate that it had a subdigitigrade posture and most likely stalked and ambushed its prey in dense cover. The postcranial morphology of Nimravides (Felidae) is most similar to the jaguar, Panthera onca. The carnivorans strongly support a latest Clarendonian age assignment for the Love Bone Bed. Although the Love Bone Bed local fauna does show some evidence of endemism at the species level, it demonstrates that by the late Clarendonian, Florida had become part of the Clarendonian chronofauna of the midcontinent, in contrast to the higher endemism present in the early Miocene and in the later Miocene and Pliocene of Florida.
Design of Church Financial Statements Based on Interpretation of Financial Accounting Standards (Isak) 35
Authors: Mariati Munte Mei Hotma , Sijabat Jadongan , Panggabean Solomon Slow
Published: February 2024

The church is an entity that aims not to make a profit, so financial accountability is an important aspect of the church. Good financial accountability can only be realized if the financial reports’ church accepts financial accounting standards. The financial accounting standard governing the financial reporting financial reporting of nonprofit-reinterpretation of Financial Accounting Standards (ISAK) 35. By applying ISAK 35 in presenting church financial reports, it is hoped that parties interested in the church can assess the performance of church management and increase the congregation’s trust in the church administrator. The research location is at the HKBP Bandar Klippa Resort Epiphanias Tembung District X Medan Aceh. Data was collected through interviews and documentation. The validity of the data was tested by the triangulation method. This study aims to present church financial reports based on ISAK 35. In 2022, HKBP Bandar Klippa will have a Rp deficit (39.736.895). Also, in 2022, there were some additional fixed assets. There are two units of fans, 1 unit of keyboard, and 1 unit of audio mics, and the Sunday school building will be inaugurated in November 2023. The change in net assets was influenced by a deficit in 2022, which becomes   Rp 1.021.626.010. HKBP Bandar Klippah's cash flow activities consist of operations and investments.
Myofibroma of the oral cavity mimicking a non-neoplastic inflammatory process
Authors: Rodrigues Éwerton Daniel Rocha , Oliveira Eder Magno Ferreira de , Ribeiro Renato da Costa , Passador-Santos Fabricio , Matos Felipe Rodrigues de , Souza Gustavo Almeida
Published: February 2024

Myofibroma is a rare condition that is a benign neoplasm characterized by the proliferation of fusiform cells originated from myofibroblasts. A 9-year-old male patient presented a intraosseous lesion in the oral cavity, which caused mobility in two teeth within appro- ximately 1 month and was submitted to excisional biopsy. Microscopic analysis revealed fragments of neoplasia of mesenchymal origin, characterized by proliferation of spindle cells with eosinophilic staining, showing loose chromatin and indistinct cytoplasmic boundaries, as well as cells with vacuolated cytoplasm. The lesion was very cellular and organized into a bundle of intersecting neoplastic cells. In the immunohistochemical analysis, the proliferative index evaluated for the Ki-67 antibody was below 5%. Neoplas- tic cells were strongly positive for the smooth muscle actin antibody. Rare mitoses were observed in the specimen, leading to the diagnosis of myofibroma. After the diagnosis, the patient was referred to his pediatrician for investigation of possible myofibromatosis. After clinical and imaging analysis, no similar lesions were found, and the diagnosis of myofibromatosis was excluded. At 6 months postoperative, the patient returned to the outpatient clinic, without clinical and radiographic signs of recurrence and buccal tissues with normal appearance.
Follicular adenomatoid odontogenic tumor of a pediatric patient
Authors: Pimentel Ana Carolina Lemos , Fortuna Tila , Medrado Alena Ribeiro Alves Peixoto , Reis Sílvia Regina de Almeida , Marchionni Antônio Márcio Teixeira
Published: February 2024

Adenomatoid odontogenic tumor (AOT) comprises about 3% of all odontogenic tumors. Rare, benign, slow-growing tumor with increase in volume, associated with a lack of tooth eruption, with female predilection. This study aims to report a case of pediatric patient diagnosed with follicular AOT, treated satisfactorily by surgical excision. 11-year-old girl had increase in volume at right maxilla, with asymptomatic evolution of 1 year. Intra-oral examination showed expansion of buccal cortical bone, erosion of vestibule fundus, and absence of 1.3 and 1.4 dental units. Incisional biopsy confirmed AOT diagnosis. Treatment choice was surgical enucleation with curettage under general anesthesia. Dental units were removed due to impossibility of orthodontic traction. In 2nd postoperative year, regression of volume was observed. Radiographic exam showed bone neoformation with no signs of lesion recurrence. Due to the rarity of this tumor it is important that all cases are described to contribute to literature and statistical data.
Clinical presentation heterogeneity of HSV1 oral lesions in immunosuppressed patients
Authors: Stramandinoli-Zanicotti Roberta Targa , Mazur Carolina Eurich , Schussel Juliana Lucena , Amenábar José Miguel , Torres-Pereira Cassius C
Published: February 2024

Herpes simplex virus type 1 (HSV-1) may be considered the main etiological viral agent in oral infections. As its symptoms bear similarity with other oral lesions within immunosu- ppressed patients, the diagnosis of herpes may be mistaken for other diseases. Therefore, the investigation of a technique that better detects this virus is important to assure a treatment that is more effective and adequate for this case. The study aimed to describe four cases of immunosuppressed patients presenting HSV-1 lesions, whose diagnosis was confirmed using polymerase chain reaction (PCR). Four hematopoietic stem cell transplant patients referred to the dental clinic complaining about oral lesions, pain, and functional difficulties. Multiple ulcers were observed in different sites of the mouth. Exfoliative cytology was performed and the diagnosis was confirmed by qualitative real-time PCR, in which HSV-1 was detected in the four cases. Specific techniques for the diagnosis of viral infections should be instituted for immunosuppressed patients presenting oral ulcers, since opportunistic infections can spread rapidly in these individuals, leading to increased morbidity and mortality.
Management of oral late sequelae in head and neck cancer long-term survivor awaiting re-irradiation
Authors: Macedo Larissa Fernanda dos Santos Lima , Siqueira Juliana Mota , Gonçales Luara Maria Cerioni , Gallo Camila de Barros , Domaneschi Carina
Published: February 2024

Head and Neck Squamous Cell Carcinoma (HNSCC) constitute more than 90% of the head and neck cancer cases, often presenting as a locally advanced disease. As techniques are improving, life expectancy of HNSCC patients have risen overtime, leading to a larger number of people facing late sequelae that often culminate in a direct and significant impact on their quality of life. For those individuals, recurrence may represent a concern for curative attempts and overall survival rates. This paper reports a clinical case of a long-term HNSCC survivor who developed multiple oral sequelae from previous cancer treatment and recent second malignancies; in order to proceed for re-irradiation, she was referred for oral assessment. Due to her age and comorbidities, private professionals reportedly refused to provide oral care, causing an immense delay to her oncology treatment that led to the progression of diverse oral symptoms and cancer itself. Considering the urgency of head and neck re-RT, the outlined oral treatment plan was conservative and included scaling and root planing, oral prophylaxis, direct resin composite restorations and hygiene orientation, in a single session. She was also referred for low-level lasertherapy. Afterwards, her health had deteriorated to such a stage she did not qualify to actually proceed for re-RT, and instead was treated with end-of-life care until the time of her death, 8 months after the above-mentioned appointments. The authors believe the prolonged search for proper oral care was significant to her already poor prognosis, as it caused an immense delay to the start of the cancer treatment.
Ewing sarcoma/primitive neuroectodermal tumor with chondroid differentiation
Authors: Mussi Maria Carolina Martins , Pigatti Fernanda Mombrini , Tobouti Priscila Lie , Sedassar Bruno Tavares , Pinto Junior Decio dos-Santos , Sousa Suzana Cantanhede Orsini Machado de
Published: February 2024

Ewing sarcoma/Primitive neuroectodermal tumor (ES/PNET) with chondroid differen- tiation and mesenchymal chondrosarcoma (MSC) have similar histopathological features. It may be difficult to distinguish both lesions without genetic or molecular analysis. The main aim of this case report is to highlight the difficulty in establishing the diagnosis of ES/ PNET with areas of chondroid differentiation. A 14-year-old female patient with painful right mandibular swelling. Imaging exams showed an extensive osteolytic lesion with mineralized areas. Histomorphologic and immunohistochemistry studies were performed. In situ hybridization was necessary to confirm the diagnosis. Immunohistochemistry and H&E-stained sections did not provide sufficient evidence to differentiate ES/PNET from MCS. The genetic tool demonstrated EWS1 gene breakpoint. ES/PNET with chondroid differentiation is rare and new studies are necessary to standardize molecular biomarkers and/or the panel of antibodies required to differentiate ES/PNET from MCS.
The role of fibrin rich platelets and leukocytes (L-PRF) in the medication-related osteonecrosis of the jaw
Authors: Parise Guilherme Klein , De-Quadros Márcio Vinicius Hurczulack , Pereira Evandro Matioski , Costa Brenda Nazareth , Patussi Cleverson , Schussel Juliana Lucena , Sassi Laurindo Moacir
Published: February 2024

Bisphosphonates (BPs), antiresorptive and antiangiogenic drugs are used to prevent metastatic bone cancers in prostate cancer, breast cancer and multiple myeloma and to treat osteoporosis and Paget’s disease. Recently, in 2003 the first case of osteonecrosis of the jaws was induced, hitherto by bisphosphonates, but a few years later it was shown that other medications were also responsible for the development of this type of necrosis. Thus, in 2014 there was a change in the name for medication-related osteonecrosis of the jaws (MRONJ). Since then, the treatment for this type of necrosis is quite controversial in the world literature, and there is still no protocol for established treatment, be it clinical or surgical. The objective of this work is to demonstrate the efficacy of platelet and leukocyte- rich fibrin membranes (L-PRF) after curettage of necrotic bone tissue in the management of drug-related jaw osteonecrosis, since they have innumerable biological benefits such as large amount of growth factors and cytokines, hemostatic capacity, angiogenesis capacity, and has been shown to accelerate and improve results in hard and soft tissue wound healing. The patient presented MRONJ and have been treated with surgical necrotic bone debridement, placement of L-PRF in the affected site and primary closure. Patient were followed up clinically and radiographically until total mucosal coverage of the necrotic bone was achieved.
Synergism between dengue and COVID-19
Authors: Labes Luiza , Trentin-Bordignon Natalia Cristina , Gondak Rogério
Published: February 2024

The global spread of the new coronavirus has brought to light several discussions regarding infectious agents and ways of transmission of viral diseases. In South America, cases of misdiagnosis between COVID-19 and dengue have been reported. This letter aimed to expose the main symptoms that confuse health professionals for the diagnosis of the acute phases of these diseases. Due to the presence of synergistic symptoms between COVID-19 and dengue in their acute phase, we sought to report marked differences between both infectious agents, based in studies published in the literature. Considering the double pandemic of COVID-19 and dengue and its impact either in the basic sanitation and the public health system, the development of an effective rapid virus tests is mandatory and useful to guide the adequate treatment of the patient. Health professionals should be alert for the synergistic symptoms of these infectious diseases. Further studies and development of more accessible and effective rapid tests are encouraged for COVID-19 and dengue.
2560 x 1440 (except while traveling)
Authors: Neylon Cameron
Published: February 2024

It’s not my joke but it still works. And given my pretty much complete failure to achieve even written resolutions it’s probably better to joke up front. But…here are a set of things I really need to write this year. Maybe more for my benefit than anyone else but it’s good to have a record.
Diversity and Inclusion are the Uniting Principle of Open Science
Authors: Neylon Cameron
Published: February 2024

I had a twitter rant and a few people asked if I would convert it into a post. It also seemed worth preserving.
Making it personal: The rare disease literature sucks
Authors: Neylon Cameron
Published: February 2024

I’ve been engaged in different ways with some people in the rare genetic disease community for a few years. In most cases the initial issue that brought us together was access to literature and in some cases that lead towards Open Science issues more generally. Many people in the Open Access space have been motivated by personal stories and losses, and quite a few of those relate to rare genetic diseases.
A Brief Introduction to Retrieval Augmented Generation (RAG)
Authors: Aryani Amir
Published: February 2024

Authors: Hui Yin , Amir Aryani With the increasing application of large language models in various scenarios, people realize that these models are not omnipotent. When generating dialogues (Shuster et al., 2021), the models often produce hallucinations, leading to inaccurate answers.
FAIR enough? FAIR for one? FAIR for all!
Authors: Neylon Cameron
Published: February 2024

The development of the acronym “FAIR” to describe open data was a stroke of genius. Standing for “Findable, Accessible, Interoperable and Reusable” it describes four attributes of datasets that are aspirations to achieve machine readability and re-use for an open data world.
Licensing, ethics and patient privacy
Authors: Neylon Cameron
Published: February 2024

Following one ofÂ “those” conversations on twitter, the ones where the 140 character limit just isn’t enough it seemed worth writing up a quick post. It’s that or follow the US election after all… Richard Sever of Cold Spring Harbour Press posed the following question on: …to which my answer was: You can follow the conversation via the links above but here I just wanted to flesh out the disagreement and why I think this matters.
Open Access Progress: Anecdotes from close to home
Authors: Neylon Cameron
Published: February 2024

It has become rather fashionable in some circles to decry the complain about the lackÂ of progress on Open Access. Particularly to decry the apparent failure of UK policies to move things forward. I’ve been guilty of frustration at various stages in the past and one thing I’ve always found useful isÂ thinking back to where things were.
Speculation: Learning, Teaching and Knowledge Making
Authors: Neylon Cameron
Published: February 2024

I’ve just read Lave and Wenger’s (1991) book

Situated Learning

on the recommendation of Isla Gershon. Like many books I’ve been reading this was radical in its time but reads in some ways to me today as common sense. It’s actually quite hard for me to reconstruct the world view in which this was seen as a dangerously radical departure.
Scholarly Communications: Less of a market, more like general taxation?
Authors: Neylon Cameron
Published: February 2024

This is necessarily speculative and I can’t claim to have bottomed out all the potential issues with this framing. It therefore stands as one of the “thinking in progress” posts I promised earlier in the year. Nonetheless it does seem like an interesting framing to pursue an understanding of scholarly communications through.

The idea of “the market” in scholarly communications has rubbed me up the wrong way for a long time.
Critiquing the Standard Analytics Paper (reprise)
Authors: Neylon Cameron
Published: February 2024

This morning I received an email from a senior policy person. They’d read my blog post on Marginal Costs of Article Publishing but they couldn’t seem to get to the original article from Standard Analytics that I was commenting on. I took a look myself and found the following.
What’s the return? Or…how is it possible that Open Library of Humanities works?
Authors: Neylon Cameron
Published: February 2024

Following on from my post yesterday a couple of questions popped up about collective and collectivist models in scholarly communications. Richard Poynder is skeptical, which left me nonplussed because from where I sit what I described is happening all over the place. Funders are looking at investment strategies, collectives are forming and some of them are growing very rapidly. Which brings us to the second and more concrete question.
Not what, not who, or how, but Why is Open?
Authors: Neylon Cameron
Published: February 2024

This is an approximation of my talk at OpenCon Cambridge on Thursday 26 November 2015. Any inaccuracies entirely mine. There is also a video recording of the actual talk.

The idea of OpenCon was borne out of the idea that the future belonged to young scholars and that helping them to be effective advocates for the world they want to work in was the best way to make progress.
Beyond the culture clash: Developing leadership for open organisations
Authors: Neylon Cameron
Published: February 2024

It has been painful to watch the tensions at the Wikimedia Foundation explode over the last few months and with the stepping down of the Executive Director there seems a mood of conciliation and a desire for WMF to learn from the process. I know next to nothing of the details or the story, so while it is the spur for this post I don’t want to offer any opinions on WMF itself.
Against the 2.5% Commitment
Authors: Neylon Cameron
Published: February 2024

Three things come together to make this post. The first is the paper

The 2.5% Commitment

by David Lewis, which argues essentially for top slicing a percentage off library budgets to pay for shared infrastructures.
Epistemic diversity and knowledge production
Authors: Neylon Cameron
Published: February 2024

Consider this yet another commitment to trying to write here a little more regularly. Lots of thinking has been going on but not much writing! At least not writing as I’m going…

Three things colliding over the past few weeks have led me to want to try and get some ideas down.
What measurement does to us…
Authors: Neylon Cameron
Published: February 2024

Over the past week this tweet was doing the rounds. I’m not sure where it comes from or precisely what its original context was, but it appeared in my feed from folks in various student analytics and big data crowds. The message I took was “measurement looks complicated until you pin it down”. But what I took from this was something a bit different. Once upon a time the idea of temperature was a complex thing.
The selection parameter for the operation and maintenance dam based on activity-based costing
Authors: Juliastuti J , Alisjahbana Sofia , Wijayanti Yureana , Mohamad Ma'soem , Setyandito Oki
Published: February 2024

Potential risks to people exist if a dam collapses and has a significant impact on the downstream area. Many countries are now facing the problem of having to deal with deteriorated infrastructure due to a lack of maintenance budgeting. This paper presents the dominant parameter in an Operational and Maintenance (OM) dam to build a cost estimation model to maintain the service life of the dam. The method used to identify cost-triggering parameters is based on activity-based costing and dam performance assessments using a combination of the modified Andersen, International Commission of Large Dams (ICOLD), and Dam Commission. The parameter was collected from fourteen independent variables, namely: dam height, irrigation area, sedimentation volume, grass area, wood vegetation area, corrosion area, concrete area, daily worker, corrosion expert, concrete deterioration, hydromechanical, physical performance, operation performance, and safety performance. The results of the model indicate that height, wood vegetation area, concrete maintenance area, hydromechanical deterioration, and safety performance are variables that affect OM costs. The OM costs can be reduced if the safety performance variable increases. This condition implies that if the safety performance component consists of dam monitoring activities, periodic inspections, green belt maintenance, water quality maintenance, and public awareness, the OM costs will decrease by 10%.
Determination of orientation parameters and automatic wind wheel speed control
Authors: Sagynysh Nurkimbayev , Shumeiko Ivan , Kassenov Assylbek , Itybaeva Galya
Published: February 2024

The design of the wind wheel and storm protection will help greatly improve the performance and safety of the wind-powered water-lifting unit. This, in turn, will contribute to improving the quality of life of rural residents. The authors of this study developed the design of a wind-powered water-lifting unit. The research aims to develop a wind-powered water-lifting unit with a capacity of up to 2.5 m3/hour, resistant to hurricane gusts of wind, with automatic control of wind wheel speed. The mathematical expressions used consider the force of the airflow and the screen area of the side blade, which takes the plane of the wind wheel out of the wind when it increases to values above the permissible operating wind speed. Numerical methods were used to calculate the forces on the spring returning the wind wheel plane to the initial position at different wind speeds. The dependences of the effect of airflow velocity on the free rotation of the wind wheel, i.e., without its running out of the wind, have been determined.
An approach to optimization of Gated Recurrent Unit with Greedy Algorithm
Authors: Lazcano-Muñoz Patricio
Published: February 2024

This study focuses on enhancing the performance of Stacked Gated Recurrent Unit (GRU) model in time series data processing, specifically in stock price prediction. The most significant innovation occurs in the integration of a Greedy Algorithm for optimizing hyperparameters such as look-back period, number of epochs, batch size, and units in each GRU layer. Historical stock data from Apple Inc. is utilized for the model's application, emphasizing the model's effectiveness in predicting stock prices. The study methodology involves a sequence of steps, such as data loading, preprocessing, dataset splitting, model construction, and evaluation. The role of the Greedy Algorithm is to iteratively adjust hyperparameters to minimize the Root Mean Squared Error (RMSE) metric, resulting in refining the model's predictive accuracy. The outcomes reveal that the integrated Greedy Algorithm significantly enhances the model's accuracy in predicting stock prices, indicating its potential application in various scenarios requiring precise time series forecasting.
Precision matters: Repeatability and reproducibility of total PSA and homocysteine measurements in Alinity i-system
Authors: Grari Oussama , Himri Amina , Douzi Nisma , Beyyoudh Soufiane , Elkhamlichi Imad-Eddine , Benaissa Kaoutar , Elmoujtahide Dounia , Sebbar El-Houcine , Choukri Mohammed
Published: February 2024

Background: The precision of test measurements is critical in clinical diagnostics, especially for biomarkers like total PSA and homocysteine, which are essential to disease assessment. Using the CMIA approach, this study investigates the repeatability and reproducibility of these biomarkers on the Abbott Alinity system. Methods: The present study was conducted in the clinical chemistry laboratory at Mohammed VI University Hospital of Oujda. The evaluation of the Alinity i-system's analytical performance for total PSA and homocysteine focused on assessing repeatability and intermediate precision. The assessment followed the protocols and guidelines established by the French Accreditation Committee (COFRAC). Results: Our analysis yielded favorable findings regarding the performance of the Alinity assays. The coefficients of variation for both the within-run and between-run precision were less than 5.89% and 4.29%, respectively. These findings produce acceptable outcomes compared to the manufacturer's claims and the SFBC database. Our study underscores the tests' precision, affirming the CMIA method's reliability in measuring total PSA and homocysteine levels. Conclusions: The assessment of the Alinity i-system for total PSA and homocysteine showed significant analytical performance. Our findings have implications for laboratory personnel, researchers, and physicians supporting a continuous diagnostic accuracy improvement culture.
Sosialisasi dan Simulasi Mitigasi Bencana dan Pertolongan Pertama pada Gen-Z di Kota Jayapura
Authors: Mujadi Mujadi , Tammubua Milcha Handayani , Suratni Suratni , Rivaldhy Rivaldhy , Monika Restu
Published: February 2024

Natural disasters cannot be avoided. The provision that can be given is to provide training to all elements of society so that they have the ability to be able to face natural disasters. disaster mitigation and first aid that was held was to increase public awareness about the risk of natural disasters, increase public knowledge in dealing with disasters and increase knowledge about examples of disaster response simulations. The urgency of this activity is to equip generation Z (Gen-Z) in responding to disaster conditions. The partner in this activity is Basarnas with training participants are the community, students and students. Knowledge and techniques to save themselves and victims of natural disasters are important points for Gen-z to remain socialised and not always dependent on technology.
Educação Ambiental Crítica para a abordagem da crise ambiental e da problemática da poluição plástica no Ensino Médio
Authors: Flores Brenda , Falavigna Gladis
Published: February 2024

A crise ambiental, resultante da dinâmica de exploração da natureza que se instaurou na sociedade industrial graças à incessante busca pela expansão do ciclo de produção e consumo, tem a geração e o descarte de resíduos como alguns de seus aspectos mais problemáticos. Nesse contexto, a poluição plástica assume papel de destaque, associado à quantidade exorbitante e crescente de resíduos plásticos despejada nos ecossistemas e à alta resistência apresentada pelo material. Portanto, em virtude da gravidade da situação e da demanda por propostas que favoreçam o desenvolvimento da consciência ambiental e a mudança de atitude dos estudantes, o produto educacional elaborado apresenta uma proposta de Educação Ambiental a partir de uma abordagem crítica, reflexiva e dialógica. O material didático-instrucional, composto por quatro roteiros de aprendizagem, foi aplicado com alunos de uma turma de segundo ano do Novo Ensino Médio de uma escola pública. A efetividade da proposta foi atestada a partir da observação da participação e do desempenho dos estudantes durante a realização das atividades e da comparação e Análise Textual Discursiva das respostas coletadas nos questionários aplicados antes e depois da implementação do produto educacional. Os resultados obtidos demonstraram o desenvolvimento da consciência ambiental possibilitado pelo aprofundamento da compreensão dos alunos acerca das questões sociais, políticas, econômicas e culturais envolvidas na crise ambiental e na problemática da poluição plástica.