bluuebunny/crossref_metadata_2025 huggingface dataset:
Barley AGO4 proteins show overlapping functionality with distinct small RNA-binding properties in heterologous complementation
Authors: Miloro Fabio , Kis András , Havelda Zoltán , Dalmadi Ágnes
Published: March 2024

Key message

Barley AGO4 proteins complement expressional changes of epigenetically regulated genes in Arabidopsis ago4-3 mutant and show a distinct affinity for the 5′ terminal nucleotide of small RNAs, demonstrating functional conservation and divergence.

The function of Argonaute 4 (AGO4) in Arabidopsis thaliana has been extensively characterized; however, its role in monocots, which have large genomes abundantly supplemented with transposable elements (TEs), remains elusive. The study of barley AGO4 proteins can provide insights into the conserved aspects of RNA-directed DNA methylation (RdDM) and could also have further applications in the field of epigenetics or crop improvement. Bioinformatic analysis of RNA sequencing data identified two active AGO4 genes in barley, HvAGO4a and HvAGO4b. These genes function similar to AtAGO4 in an Arabidopsis heterologous complementation system, primarily binding to 24-nucleotide long small RNAs (sRNAs) and triggering methylation at specific target loci. Like AtAGO4, HvAGO4B exhibits a preference for binding sRNAs with 5′ adenine residue, while also accepting 5′ guanine, uracil, and cytosine residues. In contrast, HvAGO4A selectively binds only sRNAs with a 5′ adenine residue. The diverse binding capacity of barley AGO4 proteins is reflected in TE-derived sRNAs and in their varying abundance. Both barley AGO4 proteins effectively restore the levels of extrachromosomal DNA and transcript abundancy of the heat-activated ONSEN retrotransposon to those observed in wild-type Arabidopsis plants. Our study provides insight into the distinct binding specificities and involvement in TE regulation of barley AGO4 proteins in Arabidopsis by heterologous complementation.
Cost-effectiveness of quality improvement intervention to reduce time between CT-detection and ureteroscopic laser fragmentation in acute symptomatic ureteric stones management
Authors: Khopekar Faid , Nabi Soha , Shiva Mehdi , Stewart Morven , Rajendran Benedict , Nabi Ghulam
Published: March 2024

Objective

To prospectively assess clinical and cost effectiveness of emergency ureteroscopic laser fragmentation of urinary stones causing symptoms or obstruction.

Patients and methods

100 consecutive patients with an average (median) age 55.6 (57.5) years and average (median) stone size of 8.2 mm (± 7 mm) between October 2018 and December 2021 who underwent emergency ureteroscopy and laser fragmentation formed the study cohort as part of a clinical service quality improvement. Primary outcome was single procedure stone-free rate and cost-effectiveness. The secondary outcomes were complications, re-admission and re-intervention. A decision analysis model was constructed to compare the cost-effectiveness of emergency ureteroscopy with laser fragmentation (EUL) and emergency temporary stenting followed by delayed ureteroscopy with laser fragmentation (DUL) using our results and success rates for modelling.

Results

Single procedure stone-free rates (SFR) for EUL and DUL were 85%. The re-intervention rate, re-admission and complication rates of the study cohort (EUL) were 9%, 18%, and 4%, respectively, compared to 15%, 20%, and 5%, respectively for the control cohort (DUL). The decision analysis modelling demonstrated that the EUL treatment option was more cost-efficient, averting £2868 (€3260) per patient for the UK health sector. Total cost of delayed intervention was £7783 (€8847) for DUL in contrast to £4915 (€5580) for EUL.

Conclusions

Implementation of quality improvement project based on a reduction in CT detection-to-laser fragmentation time interval in acute ureteric obstruction or symptoms caused by stones had similar clinical effectiveness compared to delayed ureteroscopic management, but more cost-effective.
Ureteral wall thickness as a predictor for non-invasive treatment success for steinstrasse. Can we save time?
Authors: Elbaset M. A. , Taha Diaa-Eldin , Anas Marwan , Elghareeb Ahmed , Abouelkheir Rasha T. , Ashour Rawdy , Sheir K. Z. , Osman Yasser
Published: March 2024

Purpose

We aimed to define factors affecting the non-invasive overall treatment success (medical expulsive therapy (MET) ± shock wave lithotripsy (SWL)) for uncomplicated ureteral steinstrasse (SS) clearance.

Methods

We retrospectively evaluated consecutive patients who underwent SWL for renal stones between 2017 and 2021. Patients with uncomplicated SS were included. All patient’s demographic and radiological data, e.g., age, gender, pre-SWL stenting, SS site, type, leading stone size in widest diameter (< 10 mm and ≥ 10 mm), ureteral wall thickness (UWT) in mm against the leading stone were collected. If SS was diagnosed, medical treatment was given for 4 weeks. In case of MET failure, either SWL for the leading stones + MET or direct URS was done. Non-invasive treatment success (SFR) was considered if complete clearance of SS occurred with no complications or the need for invasive intervention.

Results

A total of 145 patients were included with mean age of 45.9 ± 12.4 years. SFR in case of MET only occurred in 27.9%. Complications happened in 26 patients (17.9%). Non-invasive treatment SFR was achieved in 78 patients (53.8%) totally where SS type I, leading stone size ≤ 10 mm type and decreased UWT around the leading stone increased treatment success.

Conclusion

Ureteral wall thickness is an important factor predicting SS management success. Besides the decreased UWT, non-invasive management should be offered for type I SS with leading stone ≤ 10 mm.
CurveML: a benchmark for evaluating and training learning-based methods of classification, recognition, and fitting of plane curves
Authors: Raffo Andrea , Ranieri Andrea , Romanengo Chiara , Falcidieno Bianca , Biasotti Silvia
Published: March 2024

We propose CurveML, a benchmark for evaluating and comparing methods for the classification and identification of plane curves represented as point sets. The dataset is composed of 520k curves, of which 280k are generated from specific families characterised by distinctive shapes, and 240k are obtained from Bézier or composite Bézier curves. The dataset was generated starting from the parametric equations of the selected curves making it easily extensible. It is split into training, validation, and test sets to make it usable by learning-based methods, and it contains curves perturbed with different kinds of point set artefacts. To evaluate the detection of curves in point sets, our benchmark includes various metrics with particular care on what concerns the classification and approximation accuracy. Finally, we provide a comprehensive set of accompanying demonstrations, showcasing curve classification, and parameter regression tasks using both ResNet-based and PointNet-based networks. These demonstrations encompass 14 experiments, with each network type comprising 7 runs: 1 for classification and 6 for regression of the 6 defining parameters of plane curves. The corresponding Jupyter notebooks with training procedures, evaluations, and pre-trained models are also included for a thorough understanding of the methodologies employed.
Ocean response to a century of observation-based freshwater forcing around Greenland in EC-Earth3
Authors: Devilliers Marion , Yang Shuting , Drews Annika , Schmith Torben , Olsen Steffen M.
Published: March 2024

The acceleration of Greenland ice sheet melting over the past decades is raising concern regarding the impacts on ocean circulation in the North Atlantic and Arctic regions. Global climate models struggle to assess these impacts as they do not include a realistic amount of meltwater from the Greenland ice sheet. Using an extended observation-based dataset of runoff and solid ice discharge for the recent historical period (1920–2019), we force the EC-Earth3 climate model following the ensemble approach and protocol of a previous study using a different model. We observe a slight increase of the ensemble mean AMOC with a large spread in the response: $$0.20\pm 0.81$$

0.20
±
0.81

Sv for the maximum AMOC at 45$$^{\circ }$$

∘

N. We notice that members with a strong initial AMOC state (18 Sv) show a strengthening of the AMOC, while members with intermediate AMOC strength between 16 and 18 Sv are not affected by the freshwater forcing. Weaker initial AMOC members respond with a mean weakening of $${-}\,0.21\pm 0.58$$

-

0.21
±
0.58

 Sv of the AMOC. The AMOC ensemble spread is reduced by half in the freshwater forced ensemble at the end of the experiment and the negative trend is stronger compared to historical simulations without the forcing. This suggests the possible ability of the freshwater to constrain AMOC variability on multi-decadal time-scales. Comparison of the two ten member ensembles with ORAS5 reanalysis shows a reduction of the surface temperature and salinity biases in the freshwater forced ensemble in key regions such as the North Atlantic subpolar gyre and the Beaufort Gyre relative to the historical simulations. Recent trends are also more aligned with reanalysis in those regions. Arctic Ocean Atlantic Water subsurface core temperature is also closer to reanalysis but still strongly biassed. Members with a high AMOC initial state display an unrealistic Atlantic water layer core depth.
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia
Authors: Marques Christine , Held Aaron , Dorfman Katherine , Sung Joon , Song Catherine , Kavuturu Amey S. , Aguilar Corey , Russo Tommaso , Oakley Derek H. , Albers Mark W. , Hyman Bradley T. , Petrucelli Leonard , Lagier-Tourenne Clotilde , Wainger Brian J.
Published: March 2024

The stimulator of interferon genes (STING) pathway has been implicated in neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis (ALS). While prior studies have focused on STING within immune cells, little is known about STING within neurons. Here, we document neuronal activation of the STING pathway in human postmortem cortical and spinal motor neurons from individuals affected by familial or sporadic ALS. This process takes place selectively in the most vulnerable cortical and spinal motor neurons but not in neurons that are less affected by the disease. Concordant STING activation in layer V cortical motor neurons occurs in a mouse model of C9orf72 repeat-associated ALS and frontotemporal dementia (FTD). To establish that STING activation occurs in a neuron-autonomous manner, we demonstrate the integrity of the STING signaling pathway, including both upstream activators and downstream innate immune response effectors, in dissociated mouse cortical neurons and neurons derived from control human induced pluripotent stem cells (iPSCs). Human iPSC-derived neurons harboring different familial ALS-causing mutations exhibit increased STING signaling with DNA damage as a main driver. The elevated downstream inflammatory markers present in ALS iPSC-derived neurons can be suppressed with a STING inhibitor. Our results reveal an immunophenotype that consists of innate immune signaling driven by the STING pathway and occurs specifically within vulnerable neurons in ALS/FTD.
Microstructural and isotopic analysis of shocked monazite from the Hiawatha impact structure: development of porosity and its utility in dating impact craters
Authors: Hyde William R. , Kenny Gavin G. , Whitehouse Martin J. , Wirth Richard , Roddatis Vladimir , Schreiber Anja , Garde Adam A. , Plan Anders , Larsen Nicolaj K.
Published: March 2024

U–Pb geochronology of shocked monazite can be used to date hypervelocity impact events. Impact-induced recrystallisation and formation of mechanical twins in monazite have been shown to result in radiogenic Pb loss and thus constrain impact ages. However, little is known about the effect of porosity on the U–Pb system in shocked monazite. Here we investigate monazite in two impact melt rocks from the Hiawatha impact structure, Greenland by means of nano- and micrometre-scale techniques. Microstructural characterisation by scanning electron and transmission electron microscopy imaging and electron backscatter diffraction reveals shock recrystallisation, microtwins and the development of widespread micrometre- to nanometre-scale porosity. For the first time in shocked monazite, nanophases identified as cubic Pb, Pb3O4, and cerussite (PbCO3) were observed. We also find evidence for interaction with impact melt and fluids, with the formation of micrometre-scale melt-bearing channels, and the precipitation of the Pb-rich nanophases by dissolution–precipitation reactions involving pre-existing Pb-rich high-density clusters. To shed light on the response of monazite to shock metamorphism, high-spatial-resolution U–Pb dating by secondary ion mass spectrometry was completed. Recrystallised grains show the most advanced Pb loss, and together with porous grains yield concordia intercept ages within uncertainty of the previously established zircon U–Pb impact age attributed to the Hiawatha impact structure. Although porous grains alone yielded a less precise age, they are demonstrably useful in constraining impact ages. Observed relatively old apparent ages can be explained by significant retention of radiogenic lead in the form of widespread Pb nanophases. Lastly, we demonstrate that porous monazite is a valuable microtexture to search for when attempting to date poorly constrained impact structures, especially when shocked zircon or recrystallised monazite grains are not present.
Determining the state of guidance on pediatric biobanking for researchers, HRECS, and families: Regulatory mapping of international guidance
Authors: Prince Sinead , Then Shih-Ning , O’Grady Kerry-Ann
Published: March 2024

Biobanking—the storage of human biological samples, including tissue, blood, urine, and genetic data—raises many ethical, legal, and social issues, including confidentiality and privacy. Pediatric biobanking is more complicated, with difficulties arising because children lack capacity to consent and acquire this capacity upon maturity when the research is still ongoing. Yet given the limited availability of pediatric samples, the translational nature of biobanking presents a unique opportunity to share samples and produce clinically necessary information about pediatric development and diseases. Guidance on navigating these legal and ethical difficulties is needed for those involved in pediatric biobanking—including researchers, participants, and families, and those involved in biobank governance. This paper seeks to map the current regulatory framework governing pediatric biobanking to determine what guidance is currently offered. Regulatory mapping of current international and national guidelines on pediatric biobanking addressing the ethical, legal, and social nuances of pediatric biobanking was undertaken. This paper finds that international guidelines around biobanking are mostly for adults, and even when pediatric-specific, documents are non-binding, inconsistent, or only limited guidance is offered on a range of important issues specific to pediatric biobanks.

  Conclusion: This paper shows a need for consistent, comprehensive, and clear regulation on pediatric biobanking so that research can more quickly, efficiently, and ethically be translated to useful information and treatment in pediatric care.

What is Known:• Pediatric biobanking presents new opportunities to conduct valuable translational research to benefit pediatric populations. However, the storage of pediatric biological samples raises many ethical, legal and social issues—in part because child participants may be considered to lack capacity to consent but can acquire this capacity upon maturity when the research is still ongoing. Pediatric biobanks must grapple with issues of consent, confidentiality and privacy, and long-term participation regarding child participants.

What is New:• Regulatory guidance on these ethical, legal, and social issues is needed for researchers, participants, and families and those involved in biobank governance. This paper identifies nationally specific and international guidance on biobanking and summarizes the guidance provided in relation to these pediatric specific issues. It finds that most guidance is non-binding and inconsistent between guidance documents and may offer only limited guidance to stakeholders. A need for consistent, comprehensive, and clear regulation on pediatric biobanking is needed at an international level to enable research.
Five-phase space vector carrier-based PWM for third harmonic injection
Authors: Ramos Friedmann Marc , Möller Alexander , Binder Andreas
Published: March 2024

Five-phase AC drives allow a third harmonic voltage to be fed into the stator winding – in addition to the fundamental voltage – to generate a third harmonic magnetic air gap field. This allows the generation of an additional small constant torque. Furthermore, the undesirable saturation harmonics that occur with saturated iron can be compensated. The desired third harmonic voltage is commonly generated via time-consuming space vector PWM algorithms, which are not well-suited for real-time application, or via look-up tables, which require an increased storage capacity. In our case, the desired third harmonic voltage is generated in the five-phase voltages by adding a non-sinusoidal zero-sequence voltage with five times the fundamental frequency to the fundamental voltage reference signals in carrier-based pulse width modulation (PWM) with a constant switching frequency. This is equivalent to a space vector PWM method (SVPWM) and avoids a significantly high calculation effort. The PWM algorithm programmed in MATLAB in real time allows the fast generation of a third harmonic voltage per phase with freely definable amplitude and phase shift without requiring a lot of storage capacity.
Gestational diabetes perception profiles based on attachment style: a cross-sectional study
Authors: Munda Ana , Kompan Erzar Katarina Lia , Peric Helena , Pongrac Barlovič Draženka
Published: March 2024

Aims

Gestational diabetes (GDM) is a prevalent complication in pregnancy that requires effective self-management, which can be influenced by illness perceptions. Moreover, behavioral regulation can be affected by attachment styles. Thus, our study aimed to identify common GDM perception profiles and test their association with attachment styles.

Methods

In this cross-sectional study, 446 women completed the Relationship Questionnaire (RQ), the Brief Illness Perception Questionnaire (BIPQ), and additional items about GDM diagnosis, information, competence, adherence, behavioral change. Latent profile analysis (LPA) was conducted to determine GDM perception profiles. Multinomial logistic regression followed to calculate the association between GDM perception profiles and attachment styles.

Results

Three distinct profiles emerged: coping (n = 172, 38.6%)—characterized by the most positive GDM perception, burdened (n = 222, 49.8%)—indicating the emotional burden of the disease, and resourceless (n = 52, 11.7%)—reporting lack of resources (i.e. information, competence). Women with insecure attachment styles were more likely to develop a burdened GDM perception profile. Specifically, the expression of a fearful (OR = 1.184 [95%CI: 1.03; 1.36], p = 0.016) and a preoccupied (OR = 1.154 [95%CI: 1.01; 1.32], p = 0.037) attachment style increased the likelihood for a burdened perception profile, while a secure attachment style (OR = 10.791 [95%CI: 0.65; 0.96], p = 0.017) decreased likelihood for developing resourceless GDM perception profile.

Conclusions

Three GDM perception profiles were identified and the role of attachment styles in shaping these perceptions was confirmed. Further studies are needed to investigate whether a tailored treatment approach based on the predominant attachment style could lead to more positive GDM perceptions, improved glycemic control, and better perinatal outcomes.
New results on spectral synthesis
Authors: Székelyhidi László
Published: March 2024

In our former paper we introduced the concept of localization of ideals in the Fourier algebra of a locally compact Abelian group. It turns out that localizability of a closed ideal in the Fourier algebra is equivalent to the synthesizability of the annihilator of that closed ideal which corresponds to this ideal in the measure algebra. This equivalence provides an effective tool to prove synthesizability of varieties on locally compact Abelian groups. In this paper we utilize this tool to show that when investigating synthesizability of a variety, roughly speaking compact elements of the group can be neglected. Our main result is that spectral synthesis holds on a locally compact Abelian group G if and only if it holds on G/B, where B is the closed subgroup of all compact elements. In particular, spectral synthesis holds on compact Abelian groups. Also we obtain a simple proof for the characterization theorem of spectral synthesis on discrete Abelian groups.
The association between head injury and facial fracture treatment: an observational study of hospitalized bicyclists from a level 1 trauma centre
Authors: Galteland Pål , Døving Mats , Næss Ingar , Sehic Amer , Utheim Tor Paaske , Eken Torsten , Skaga Nils Oddvar , Helseth Eirik , Ramm-Pettersen Jon
Published: March 2024

Purpose

To compare the types of facial fractures and their treatment in bicyclists admitted to a level 1 trauma centre with major and minor-moderate head injury.

Methods

Retrospective analysis of data from bicycle-related injuries in the period 2005–2016 extracted from the Oslo University Hospital trauma registry.

Results

A total of 967 bicyclists with head injuries classified according to the Abbreviated Injury Scale (AIS) were included. The group suffering minor-moderate head injury (AIS Head 1–2) included 518 bicyclists, while 449 bicyclists had major head injury (AIS Head 3–6). The mean patient age was 40.2 years (range 3–91 years) and 701 patients (72%) were men. A total of 521 facial fractures were registered in 262 patients (on average 2 facial fractures per bicyclist). Bicyclists with major head injury exhibited increased odds for facial fractures compared to bicyclists with minor-moderate head injury (sex and age adjusted odds ratio (OR) 2.75, 95% confidence interval (CI) 2.03–3.72, p < 0.001. More specifically, there was increased odds for all midface fractures, but no difference for mandible fractures. There was also increased odds for orbital reconstruction in cyclist with major head injury compared to bicyclist with minor-moderate head injury (adjusted OR 3.34, 95% CI 1.30–8.60, p = 0.012).

Conclusion

Bicyclists with more severe head injuries had increased odds for midface fractures and surgical correction of orbital fractures. During trauma triage, the head and the face should be considered as one unit.
Generalized Nash equilibrium problems with mixed-integer variables
Authors: Harks Tobias , Schwarz Julian
Published: March 2024

We consider generalized Nash equilibrium problems (GNEPs) with non-convex strategy spaces and non-convex cost functions. This general class of games includes the important case of games with mixed-integer variables for which only a few results are known in the literature. We present a new approach to characterize equilibria via a convexification technique using the Nikaido–Isoda function. To any given instance of the GNEP, we construct a set of convexified instances and show that a feasible strategy profile is an equilibrium for the original instance if and only if it is an equilibrium for any convexified instance and the convexified cost functions coincide with the initial ones. We develop this convexification approach along three dimensions: We first show that for quasi-linear models, where a convexified instance exists in which for fixed strategies of the opponent players, the cost function of every player is linear and the respective strategy space is polyhedral, the convexification reduces the GNEP to a standard (non-linear) optimization problem. Secondly, we derive two complete characterizations of those GNEPs for which the convexification leads to a jointly constrained or a jointly convex GNEP, respectively. These characterizations require new concepts related to the interplay of the convex hull operator applied to restricted subsets of feasible strategies and may be interesting on their own. Note that this characterization is also computationally relevant as jointly convex GNEPs have been extensively studied in the literature. Finally, we demonstrate the applicability of our results by presenting a numerical study regarding the computation of equilibria for three classes of GNEPs related to integral network flows and discrete market equilibria.
Equilibria in schelling games: computational hardness and robustness
Authors: Kreisel Luca , Boehmer Niclas , Froese Vincent , Niedermeier Rolf
Published: March 2024

In the simplest game-theoretic formulation of Schelling’s model of segregation on graphs, agents of two different types each select their own vertex in a given graph so as to maximize the fraction of agents of their type in their occupied neighborhood. Two ways of modeling agent movement here are either to allow two agents to swap their vertices or to allow an agent to jump to a free vertex. The contributions of this paper are twofold. First, we prove that deciding the existence of a swap-equilibrium and a jump-equilibrium in this simplest model of Schelling games is NP-hard, thereby answering questions left open by Agarwal et al. [AAAI ’20] and Elkind et al. [IJCAI ’19]. Second, we introduce two measures for the robustness of equilibria in Schelling games in terms of the minimum number of edges or the minimum number of vertices that need to be deleted to make an equilibrium unstable. We prove tight lower and upper bounds on the edge- and vertex-robustness of swap-equilibria in Schelling games on different graph classes.
Analysis and experimental validation of necroptosis-related molecular classification, immune signature and feature genes in Alzheimer’s disease
Authors: Lian Piaopiao , Cai Xing , Yang Xiaoman , Ma Zhuoran , Wang Cailin , Liu Ke , Wu Yi , Cao Xuebing , Xu Yan
Published: March 2024

Necroptosis, a programmed cell death pathway, has been demonstrated to be activated in Alzheimer’s disease (AD). However, the precise role of necroptosis and its correlation with immune cell infiltration in AD remains unclear. In this study, we conducted non-negative matrix factorization clustering analysis to identify three subtypes of AD based on necroptosis-relevant genes. Notably, these subtypes exhibited varying necroptosis scores, clinical characteristics and immune infiltration signatures. Cluster B, characterized by high necroptosis scores, showed higher immune cell infiltration and was associated with a more severe pathology, potentially representing a high-risk subgroup. To identify potential biomarkers for AD within cluster B, we employed two machine learning algorithms: the least absolute shrinkage and selection operator regression and Random Forest. Subsequently, we identified eight feature genes (CARTPT, KLHL35, NRN1, NT5DC3, PCYOX1L, RHOQ, SLC6A12, and SLC38A2) that were utilized to develop a diagnosis model with remarkable predictive capacity for AD. Moreover, we conducted validation using bulk RNA-seq, single-nucleus RNA-seq, and in vivo experiments to confirm the expression of these feature genes. In summary, our study identified a novel necroptosis-related subtype of AD and eight diagnostic biomarkers, explored the roles of necroptosis in AD progression and shed new light for the clinical diagnosis and treatment of this disease.
Contact with Foster Care and the Juvenile Delinquency Court: A Prospective Examination from Birth through Age 18
Authors: Eastman Andrea Lane , Park Keunhye , Herz Denise , Dierkhising Carly B. , McCroskey Jacquelyn , Guo Lillie
Published: March 2024

Purpose

Research has demonstrated a link between out-of-home foster care and subsequent juvenile justice involvement. Understanding factors that may contribute to dual system involvement for young people who entered foster care is essential for disrupting this relationship.

Method

We used population-based linked administrative records to examine the prevalence of juvenile delinquency court petitions among individuals placed in out-of-home foster care in Los Angeles County from birth to age 18. By integrating records from child welfare and probation, this analysis of individuals born between 1998 and 2001 and who lived in the county’s out-of-home foster care system (N = 29,434) showed that 2,554 (8.7%) had encountered a juvenile delinquency court petition prior to turning 18.

Results

Regression results showed an increased rate of dual system involvement among young people in foster care who experienced unstable living conditions, periods of absence from care, commercial sexual exploitation, or group homes. Instability in living situations (staying in care for more than a year, with three or more homes or placements; RR = 1.31; CI = 1.16, 1.48) and history of group home care (RR = 1.43; CI = 1.25, 1.64) were significantly associated with a heightened rate of dual system involvement. As shown in the gender-stratified models, the magnitude of associations between dual system involvement and foster care experiences differed by gender.

Discussion

The current study aligns with prior studies showing a relationship between residential instability and group homes to subsequent delinquency court involvement. Findings set a baseline so future work can explore if policies aiming to reduce reliance on group care are associated with changes in the likelihood of dual system involvement.
The board director’s role in the relationship between organizational innovation and organizational learning in the sustainability innovation performance: an approximation from culture context
Authors: Escandon-Barbosa Diana , Salas-Paramo Jairo
Published: March 2024

This research analyzes the moderating effects of the board of directors and cultural distance in the relationship between organizational exploration and exploitation and its effect on the selection of entry modes to a country. A structural equation model is carried out with a sample of 1535 exporting companies in Colombia, Perú, Ecuador, and Bolivia. Our findings emphasize the vital role of the board of directors in shaping a company’s international market entry strategies, even in Bolivia’s distinct environment. When board directors possess the necessary competencies to navigate cultural disparities, they facilitate the complexities of entering foreign markets. Additionally, maintaining a balance between exploration and exploitation plays a pivotal role in shaping a company’s approach to market entry. This insight is valuable across diverse economic settings and contributes to academic research and practical international business decision-making.
Knowledge for the unknown? A history of the future in Swedish higher education and research policy, 1970–2020
Authors: Geschwind Lars , Gustafsson Hampus Östh
Published: March 2024

This article analyses how the future has been discussed in Swedish higher education and research policy, providing an overview of public inquiries during the period 1970–2020. Expanding on the conceptual framework of German historian Reinhart Koselleck, the article approaches discourses on the future through the analytical lens of sociology of expectations. The findings demonstrate that all inquiries that attempt to advance arguments for policy change address the future—with temporal perspectives usually limited to the coming 15–20 years—whereby the future is conceptualised as an unknown and complex ‘knowledge society’, characterised by acceleration, high demands and fierce competition. A number of inquiries discuss the future development based on empirical data like shrinking age cohorts among potential students, while others describe threats and challenges based on needs for creating a sense of urgency. Inter- and multidisciplinarity, with respect to such future needs in both research and education, is consequently a key area of discussion throughout the period in question. Several other themes emerge as prevalent, including technological change and digitalisation as well as broader issues of how to organise the curriculum and lifelong learning. The historical analysis presented in this article is crucial for ongoing university debates, as it is demonstrated that temporal dynamics and future imaginaries have been highly formative for the development of Swedish higher education and research.
Enhancement of magnetocaloric effect by partial substitution of Bi in La0.60Dy0.10Sr0.30Mn(1−x)BixO3 manganites (x = 0, 0.01, 0.03, and 0.10)
Authors: Kurt Mustafa Zeki , Kılıç Çetin Selda , Kandemir Arda , Akça Gönül , Karadağ Faruk , Ekicibil Ahmet
Published: March 2024

In this study, the effects of Bi substitution for Mn on the magnetic and magnetocaloric properties of La0.60Dy0.10Sr0.30Mn(1−x)BixO3 manganites (x = 0, 0.01, 0.03, and 0.10) synthesized using the sol–gel method ​​were investigated. The samples x = 0, 0.01, and 0.03 had been indexed in an orthorhombic structure (space group Pnma), while sample x = 0.10 had been indexed in a hexagonal structure (space group R3c). The thermomagnetic measurements showed an increase in the Curie temperature (TC) with increasing Bi content, as well as an increase in magnetization at low temperatures. The TC values were determined as 322, 318, 327, and 360 K for x = 0, 0.01, 0.03, and 0.10 samples, respectively. Maximum magnetic entropy change ($$-\Delta {S}_{M}^{max}$$

-
Δ

S

M

max

) values ​​obtained from isothermal magnetization measurements showed an increase with the amount of Bi. The $$-\Delta {S}_{M}^{max}$$

-
Δ

S

M

max

value of 3.80 Jkg−1K−1 at 5 T for the x = 0 sample increased to 4.12 Jkg−1K−1 for the x = 0.10 sample with the highest Bi content. From the Arrott curves, it was observed that all samples exhibited a second-order magnetic phase transition. The obtained values of relative cooling power (RCP), which is an important factor in determining the performance of cooling material, are in the range of 282, 262, 251, and 232 Jkg−1 for x = 0, 0.01, 0.03, and 0.10, respectively.
Top-end inequality and growth: empirical exploration of nonlinearities and the time dimension
Authors: Tuominen Elina
Published: March 2024

Using the series of the top 1% income shares in 137 countries, I examine the relationship between top-end inequality and subsequent economic growth from the 1920s to the 2010s. These data enable a versatile exploration of various time horizons. To address concerns regarding chosen functional forms, I employ penalized spline methods to accommodate potential nonlinearities. Empirical findings suggest that the relationship between top-end inequality and subsequent growth is complex, contingent upon both the investigated time horizon and the level of economic development. I find some evidence for a positive link at medium levels of economic development, with this positive link being more pronounced in short- to medium-term associations. I also find that the positive medium-run association weakens as economic development advances. In advanced economies, a negative (or nonpositive) medium- to long-term relationship emerges between the top 1% income share and growth in many settings. Furthermore, I conclude that longer-run associations need to be investigated further.
Biobased Immiscible Polylactic Acid (PLA): Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Blends: Impact of Rheological and Non-isothermal Crystallization on the Bead Foaming Behavior
Authors: Brütting Christian , Dreier Julia , Bonten Christian , Ruckdäschel Holger
Published: March 2024

Nowadays, bead foams are of great interest due to their high lightweight potential. The processing of such foams strongly depends on the crystallization and rheological behavior of the polymers used. By blending polymers, these properties can be tailored to obtain beaded foams with low density, small cell size and high cell density. As a bio-based polymer, PLA is of great interest due to its renewable carbon source. PLA suffers from its low thermal and rheological properties, which can be compensated by using blends. The correlation between the PLA/PHBV ratio and the rheological as well as the crystallization behavior was investigated. The use of PHBV as a minor phase significantly changes the rheological properties and increases the crystallization behavior of PLA. These findings were applied to the foam extrusion process to obtain low density bead foams. Bead foams with densities below 100 kg/m3, mean cell sizes below 50 µm and cell densities of 1 × 107 cells/cm3 were obtained.
Negligible In Vitro Recovery of Macromolecules from Microdialysis Using 100 kDa Probes and Dextran in Perfusion Fluid
Authors: Dorothee Spille , Sørensen G. , Olsen L. R. , Bastlund J. F. , Sotty F. , Belling D. , Olsen M. H. , Mathiesen T. I. , Møller K. , Larsen F. , Birkeland P.
Published: March 2024

Microdialysis is applied in neurointensive care to monitor cerebral glucose metabolism. If recoverable, macromolecules may also serve as biomarkers in brain disease and provide clues to their passage across the blood–brain barrier. Our study aimed to investigate the in vitro recovery of human micro- and macromolecules using microdialysis catheters and perfusion fluids approved for clinical use. In vitro microdialysis of a bulk solution containing physiological or supraphysiological concentrations of glucose, lactate, pyruvate, human IgG, serum albumin, and hemoglobin was performed using two different catheters and perfusion fluids. One had a membrane cut-off of 20 kDa and was used with a standard CNS perfusion fluid, and the other had a membrane cut-off of 100 kDa and was perfused with the same solution supplemented with dextran. The flow rate was 0.3 µl/min. We used both push and push–pull methods. Dialysate samples were collected at 2-h intervals for 6 h and analyzed for relative recovery of each substance. The mean relative recovery of glucose, pyruvate, and lactate was > 90% in all but two sets of experiments. In contrast, the relative recovery of human IgG, serum albumin, and hemoglobin from both bulk solutions was below the lower limit of quantification (LLOQ). Using a push–pull method, recovery of human IgG, serum albumin, and hemoglobin from a bulk solution with supraphysiological concentrations were above LLOQ but with low relative recovery (range 0.9%–1.6%). In summary, exchanging the microdialysis setup from a 20 kDa catheter with a standard perfusion fluid for a 100 kDa catheter with a perfusion solution containing dextran did not affect the relative recovery of glucose and its metabolites. However, it did not result in any useful recovery of the investigated macromolecules at physiological levels, either with or without a push–pull pump system.
When will the Glomerular Filtration Rate in Former Preterm Neonates Catch up with Their Term Peers?
Authors: Wu Yunjiao , Allegaert Karel , Flint Robert B. , Goulooze Sebastiaan C. , Välitalo Pyry A. J. , de Hoog Matthijs , Mulla Hussain , Sherwin Catherine M. T. , Simons Sinno H. P. , Krekels Elke H. J. , Knibbe Catherijne A. J. , Völler Swantje
Published: March 2024

Aims

Whether and when glomerular filtration rate (GFR) in preterms catches up with term peers is unknown. This study aims to develop a GFR maturation model for (pre)term-born individuals from birth to 18 years of age. Secondarily, the function is applied to data of different renally excreted drugs.

Methods

We combined published inulin clearance values and serum creatinine (Scr) concentrations in (pre)term born individuals throughout childhood. Inulin clearance was assumed to be equal to GFR, and Scr to reflect creatinine synthesis rate/GFR. We developed a GFR function consisting of GFRbirth (GFR at birth), and an Emax model dependent on PNA (with GFRmax, PNA50 (PNA at which half of $${GFR}_{max}$$

GFR

max

is reached) and Hill coefficient). The final GFR model was applied to predict gentamicin, tobramycin and vancomycin concentrations.

Result

In the GFR model, GFRbirth varied with birthweight linearly while in the PNA-based Emax equation, GA was the best covariate for PNA50, and current weight for GFRmax. The final model showed that for a child born at 26 weeks GA, absolute GFR is 18%, 63%, 80%, 92% and 96% of the GFR of a child born at 40 weeks GA at 1 month, 6 months, 1 year, 3 years and 12 years, respectively. PopPK models with the GFR maturation equations predicted concentrations of renally cleared antibiotics across (pre)term-born neonates until 18 years well.

Conclusions

GFR of preterm individuals catches up with term peers at around three years of age, implying reduced dosages of renally cleared drugs should be considered below this age.
Measuring economic insecurity by combining income and wealth: an extended well-being approach
Authors: Petrov Dmitry , Romaguera-de-la-Cruz Marina
Published: March 2024

In this paper, we propose the use of an extended well-being approach to assess economic insecurity. Our main purpose is to study its dimension and identify its main drivers in the United States by overcoming the dichotomy between income and wealth. To this end, we approximate an extended well-being measure that includes monetary resources from income and the potential stream from wealth, which can be understood as an emergency reserve to cope with future economic difficulties but could also be a source of financial distress due to fluctuations in asset holdings and prices. We find that economic insecurity levels are larger when considering our extended well-being variable than income alone. Household income and non-liquid assets appear to be the main drivers of economic insecurity, although part of the US population was able to obtain higher returns on non-liquid assets and maintain their income levels.
Conjugation-Based Approach to the $\varepsilon $-Subdifferential of Convex Suprema
Authors: Correa Rafael , Hantoute Abderrahim , López Marco A.
Published: March 2024

We provide new characterizations of the $\varepsilon $
ε
-subdifferential of the supremum of an arbitrary family of convex functions. The resulting formulas only involve approximate subdifferentials of adequate convex combinations of the data functions. Families of convex functions with a concavity-like property are introduced and their relationship with affine models is studied. The role of the lower semi-continuity of the data functions is also analyzed.
Anticoagulation control among patients on vitamin K antagonists in nine countries in Sub-Saharan Africa
Authors: Mwita Julius Chacha , Francis Joel Msafiri , Pillay Chriselda , Ogah Okechukwu S. , Goshu Dejuma Yadeta , Agyekum Francis , Musonda John Mukuka , James Maduka Chiedozie , Tefera Endale , Kabo Tsie , Ditlhabolo Keolebile Irene , Ndlovu Kagiso , Ayodele Ayoola Yekeen , Mikomangwa Wigilya P. , Chillo Pilly , Damasceno Albertino , Folson Aba Ankomaba , Oyekunle Anthony , Tebuka Erius , Kalokola Fredrick , Forrest Karen , Dunn Helena , Karaye Kamilu , Jean-Pierre Fina Lubaki , Oljira Chala Fekadu , Assefa Tamrat , Taiwo Tolulope Shogade , Nwafor Chibuike E. , Omole Olufemi , Anakwue Raphael , Cohen Karen
Published: March 2024

Vitamin K antagonists (VKA) is the primary anticoagulant in most settings of Sub-Saharan Africa. Understanding the quality of anticoagulation services in the continent is vital in optimising the intended benefits. This study assessed the quality of anticoagulation and associated factors among VKA-treated patients in nine SSA countries. We conducted a retrospective cohort study of randomly selected patients on anticoagulation from 20 clinics in Botswana, the Democratic Republic of Congo, Ethiopia, Gambia, Ghana, Mozambique, Nigeria, Tanzania, and South Africa. Eligible participants were those on VKAs for at least three months and with at least four international normalised ratios (INR) results in 2019–2021. We report the proportion of INR values in the therapeutic range, time-in-therapeutic range (TTR) using the Rosendaal method, and the proportion of patients with TTR ≥ 65% (optimal anticoagulation). The mean age was 51.1(16.1) years, and 64.2% were women. The most common indications for VKA included venous thromboembolism (29.6%), prosthetic valves (26.7%) and atrial fibrillation/flutter (30.1%). We analysed 6743 INR tests from 1011 participants, and of these, 48.5% were sub-therapeutic, 34.1% therapeutic, and 17.4% were supratherapeutic relative to disease-specific reference ranges. TTR was calculated for 660 patients using 4927 INR measurements. The median (interquartile range [IQR]) TTR was 35.8(15.9,57.2) %. Optimal anticoagulation control was evident in 19.2% of participants, varying from 2.7% in Tanzania to 23.1% in Ethiopia. The proportion of patients with TTR ≥ 65% was 15,4% for prosthetic heart valves, 21.1% for venous thromboembolism and 23.7% for atrial fibrillation or flutter. Countries with universal health coverage had higher odds of optimal anticoagulation control (adjusted odds ratio (aOR) 1.79, 95% confidence interval [CI], 1.15– 2.81, p = 0.01). Patients on VKAs for different therapeutic indications in SSA had suboptimal TTR. Universal health coverage increased the odds of achieving TTR by 79%. The evidence calls for more intensive warfarin management strategies in SSA, including providing VKA services without out-of-pocket payments.
Advancing sustainable water treatment strategies: harnessing magnetite-based photocatalysts and techno-economic analysis for enhanced wastewater management in the context of SDGs
Authors: Ngulube Khumbolake Faith , Abdelhaleem Amal , Osman Ahmed I. , Peng Lai , Nasr Mahmoud
Published: March 2024

Herein, we explore the holistic integration of magnetite-based photocatalysts and techno-economic analysis (TEA) as a sustainable approach in wastewater treatment aligned with the Sustainable Development Goals (SDGs). While considerable attention has been devoted to photocatalytic dye degradation, the nexus between these processes and techno-economic considerations remains relatively unexplored. The review comprehensively examines the fundamental characteristics of magnetite-based photocatalysts, encompassing synthesis methods, composition, and unique properties. It investigates their efficacy in photocatalytic degradation, addressing homogeneous and heterogeneous aspects while discussing strategies to optimize photodegradation efficiency, including curbing electron–hole recombination and mitigating scavenging effects and interference by ions and humic acid. Moreover, the management aspects of magnetite-based photocatalysts are examined, focusing on their reusability and regeneration post-dye removal, along with the potential for reusing treated wastewater in relevant industrial applications. From a techno-economic perspective, the study evaluates the financial feasibility of deploying magnetite-based photocatalysts in wastewater treatment, correlating reduced pollution and the marketing of treated water with social, economic, and environmental objectives. By advocating the integration of magnetite-based photocatalysts and TEA, this paper contributes insights into scalable and profitable sustainable wastewater treatment practices. It underscores the alignment of these practices with SDGs, emphasizing a comprehensive and holistic approach to managing wastewater in ways that meet environmental, economic, and societal objectives.

Graphical Abstract