bluuebunny/crossref_metadata_2025 huggingface dataset:
I Have Something Interesting To Talk To You About: Speaking To Disagree, Agreeably
Authors: Rockwood Kenneth
Published: June 2015

Working in health care can sometimes be exhilarating. At other times it is exhausting, especially if there is interpersonal conflict amongst health-care providers about the best course of action. This can occur in relation to the care of frail older adults. Physicians and other health-care professionals often are not taught how to disagree. This short essay outlines a few steps that can be followed to allow disagreements to be identified in a respectful manner, focused on a solution that requires something from each side. Given the importance of interdisciplinary collaborative care in geriatric medicine, having a structured approach to disagreement is likely to be a useful tool in the geriatrician’s kit.
Calcifying Fibrous Tumor of the Gastrointestinal Tract
Authors: Larson Brent K. , Dhall Deepti
Published: June 2015

Calcifying fibrous tumor is a benign mass lesion classically described as a soft tissue tumor. However, a thorough review of the literature reveals that it can occur virtually anywhere, including the tubular gastrointestinal (GI) tract. Its clinical manifestations are variable in the GI tract, and its imaging findings are nonspecific. However, it has unique histologic and immunophenotypical features that must be recognized by GI pathologists to differentiate it from an assortment of other rare mesenchymal lesions of the abdomen and GI tract. Calcifying fibrous tumor is composed of a paucicellular collagen matrix, interspersed calcified bodies, and a sparse inflammatory infiltrate. Although calcifying fibrous tumor is benign, pathologists must be aware that it may occur in the GI tract to differentiate it from other potentially more aggressive, rare mesenchymal lesions.
Cross-Generational Valuing Among Peer Academic Librarians
Authors: Munde Gail , Coonin Bryna
Published: June 2015

This study investigated the skills, knowledge, abilities or dispositions that are most valued and respected by academic librarians, and determined how these qualities might, or might not, be associated with generational membership. Other variables included institutional classification, career length, years since first professional degree, and broad library job function. The article explains survey design, proportional random sampling method, statistical analyses and tests, and resulting findings that may have implications for recruitment, mentoring, succession planning, and for assisting in the transmission of knowledge among academic librarians, especially from career mature librarians to their younger colleagues.
Beyond the Scanned Image: A Needs Assessment of Scholarly Users of Digital Collections
Authors: Green Harriett E. , Courtney Angela
Published: June 2015

This paper presents an analysis of how humanities scholars use digital collections in their research and the ways in which digital collections could be enhanced for scholarly use. The authors surveyed and interviewed humanities faculty from twelve research universities about their research practices with digital collections and present analysis of the resulting responses. The paper also analyzes a sample of qualitative responses from the Bamboo Technology Project’s workshops with faculty, librarians, and technologists about the use and functionalities of digital materials for humanities research. This paper synthesizes these data analyses to propose the critical need for interoperability and data curation in digital collections to increase their scholarly use, and the importance of user engagement in development of digital collections.
Narcissism and Anger: Self-Esteem and Contingencies of Self-Worth as Mediating Self-Structures
Authors: Garcia Grisel M. , Watson P. J. , Cunningham Christopher J. L. , O’Leary Brian J. , Chen Zhuo
Published: June 2015

Theory and research suggest that an internalization of psychological “structure” related to self-esteem may mediate relationships of Maladaptive Narcissism with higher and Adaptive Narcissism with lower Anger. In the present study (N = 623), Self-Esteem and Contingency of Self-Worth Scales served as presumed indices of the presence or absence of structure. Maladaptive Narcissism predicted greater Anger and a relative absence of structure whereas Adaptive Narcissism displayed an opposite pattern of results. Constructs assessing structure partially mediated the Maladaptive Narcissism relationship with greater Anger. Mediation analyses also revealed that structure not only fully mediated the inverse Adaptive Narcissism linkage with Anger, but also suppressed an association with greater Anger that would otherwise have been evident. These data supported the idea that psychological structure related to self-esteem is noteworthy in explaining the implications of narcissism for personality and interpersonal functioning.
The Effectiveness of “Undercover Anti-Bullying Teams” as Reported by Participants
Authors: Winslade John , Williams Michael , Barba Felipe , Knox Evelyn , Uppal Harpreet , Williams Juanita , Hedtke Lorraine
Published: June 2015

An analysis of archival data retrieved from a school counselor’s careful recording of student responses during the conducting of 35 “undercover anti-bullying teams” reveals a highly positive qualitative account of the success of these teams. A targeted, non-punitive, restorative process calls forth peer influence to transform the bullying relation in a short time-frame. The bullies are involved in the transformation and the victim is never required to confront the bullies. Student responses show that participants value the chance to help a peer, take up the responsibility of stopping bullying responsibly, and victims are happy with the results.
My Parents Know Best: No Mating With Members From Other Ethnic Groups
Authors: Buunk Abraham P.
Published: June 2015

This study examined the opposition against out-group mating and the attitude towards parental influence on mate choice among 107 Dutch, 69 Moroccan, and 69 Turkish participants aged between 15 and 25. The level of preferred parental influence on mate choice was considerably higher among the Turks and Moroccans than among the Dutch, but females in both ethnic groups were less in favor of parental influence on mate choice than males were. Overall, males showed a higher opposition against interethnic dating than females did, and the Turks showed a higher level of opposition to interethnic mating than both the Moroccans and the Dutch. In addition, the effect of opposition against interethnic mating on preferred parental influence on mate choice was especially pronounced among the Turks, somewhat less so among the Moroccans, and least strong among the Dutch. Especially young males with a Turkish and Moroccan background seem to hold on to the values of the cultures they come from, and particularly Turkish immigrants seem keen on keeping the cohesion of their ethnic group intact by opposing interethnic dating, and by favoring parental influence on mate choice as a way to achieve this goal.
The Membrane Sensors Sensitive to Fluoxetine - Optimization of the Analytical Parameters
Authors: Joanna Drozd
Published: June 2015

Background: The analytical characteristics of electrodes containing liquid PVC membrane depend on the purity of the electroactive material and the applied membrane solvents.Methods: Fluoxetine - one H-bond donor, formed ion-associated complexes with tetraphenylborate, tetrakis(4-chlorophenyl)borate and dipicrylamine. To confirm the quality and purity obtained complexes the elemental and TLC analysis were performed. The construction and general characteristics of fluoxetine ion-selective plastic membrane sensors, based on the use of a fluoxetine – tetrakis(4-chlorophenyl)borate ion-pair complex as electroactive material with 2-nitrophenyloctyl ether, bis(2-ethylhexyl)sebacate, bis(2-butylpentyl)adipate and 1-isopropyl-4-nitrobenzene as solvent mediators.Results: The electrode containing Fl-ClTPB-NPhOE (fluoxetine-tetrakis(4-chlorophenyl)borate-2-nitrophenyloctyl ether showed a linear response to fluoxetine at concentration ranges of 30.93 – 2.16 g·L-1 with a super Nernstian cationic slope 60.19 mV·decade-1.Conclusions: This Fl-ClTPB-NPhOE sensor was used for the potentiometric determination of the content of fluoxetine hydrochloride in pure form and pharmaceutical formula.
Low-protein diet for chronic kidney disease in the Caserta Local Health Unit: the SaniARP Initiative
Authors: Troncone Chiara , Menditto Enrica , Orlando Valentina , Valiante Daniela , Farina Giuseppina , Tari Michele Giuseppe
Published: June 2015

INTRODUCTION: In clinical practice, the interest in the use of low-protein food for patients suffering from chronic kidneydisease has increased. Currently, these products are not yet contemplated in the essential levels of assistance but the Italian regions deliver, low-protein food discretionally using their own funds. The Campania Region, in 2010, interrupted the distribution of these products. With the exception of Caserta which took up distribution again in 2013. OBJECTIVE: The aim of this paper is to describe an initiative put in place by Caserta which has decided to invest in prevention. MATERIALS AND METHODS: A treatment plan for the distribution designed by a team of in-house nephrologists and data are recorded using Saniarp, a web-based platform. RESULTS: In the observation period patients with a prescription of low-protein food products were 869. The mean age was 61 years. The average cost patient / month for the nutritional treatment was 59 Euro. The average cost patient / month for any type of drug was 632 Euro. In particular, 48 Euro for EPO, 277 Euro for Chelate Agents, 16 Euro for antihypertensive therapy. DISCUSSION AND CONCLUSIONS: The policy put in place by the LHU Caserta improved care of kidney patients. The results available to date are still incomplete and do not enable us to clearly assess the benefits both in clinical and economic terms which can be produced by a low-protein diet in kidney patients. In the perspective of third party payers to budget this expense it appears entirely sustainable especially in view of the fact that this dietary treatment might delay the onset of dialysis therapy and lead to lower comorbidity for the patient.
Un soutien dans le processus d’accompagnement citoyen : une nécessité pour la santé mentale des accompagnateurs-citoyens
Authors: Therriault Pierre-Yves , Samuelson Jacinthe
Published: June 2015

Le projet d’accompagnement citoyen personnalisé en intégration communautaire (APIC) consiste en l’accompagnement de personnes ayant un problème de santé. Cet accompagnement a lieu lors de la réalisation d’activités qui sont significatives pour l’accompagné. Mais au-delà de l’accompagnement, le processus relationnel s’avère important et complexe. L’objectif du présent article est de proposer une analyse de l’influence des contraintes de pratique sur la santé psychologique d’accompagnateur-citoyen (Ac) d’un point de vue de la psychodynamique du travail. Les résultats émanent d’un suivi de ce processus auprès de dix personnes occupant le rôle d’Ac lors de l’accompagnement de personnes ayant subi un traumatisme cranio-cérébral (TCC). L’étude du phénomène, du point de vue des acteurs, permet de penser à la mise en place d’un soutien et d’outils nécessaires pour éviter les risques pour la santé mentale des Ac.
The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus
Authors: Kraemer Moritz UG , Sinka Marianne E , Duda Kirsten A , Mylne Adrian QN , Shearer Freya M , Barker Christopher M , Moore Chester G , Carvalho Roberta G , Coelho Giovanini E , Van Bortel Wim , Hendrickx Guy , Schaffner Francis , Elyazar Iqbal RF , Teng Hwa-Jen , Brady Oliver J , Messina Jane P , Pigott David M , Scott Thomas W , Smith David L , Wint GR William , Golding Nick , Hay Simon I
Published: June 2015

Dengue and chikungunya are increasing global public health concerns due to their rapid geographical spread and increasing disease burden. Knowledge of the contemporary distribution of their shared vectors, Aedes aegypti and Aedes albopictus remains incomplete and is complicated by an ongoing range expansion fuelled by increased global trade and travel. Mapping the global distribution of these vectors and the geographical determinants of their ranges is essential for public health planning. Here we compile the largest contemporary database for both species and pair it with relevant environmental variables predicting their global distribution. We show Aedes distributions to be the widest ever recorded; now extensive in all continents, including North America and Europe. These maps will help define the spatial limits of current autochthonous transmission of dengue and chikungunya viruses. It is only with this kind of rigorous entomological baseline that we can hope to project future health impacts of these viruses.
Removal of arsenious acid from sulfuric acidic solution using ultrasound oxidation and goethite
Authors: Okawa Hirokazu , Yoshikawa Tomohiro , Hosokawa Ryota , Hangui Shinji , Kawamura Youhei , Sugawara Katsuyasu
Published: June 2015

We investigated the properties of synthetic goethite for the adsorption of As from strongly acidic solutions in ambient atmosphere under ultrasound irradiation. The goethite was successfully synthesized from iron-containing sulfuric acidic solution (1271 ppm) using an autoclave apparatus for 1 h at 0.12 MPa and 121 °C. The ratio of the iron eluted from the synthetic goethite to the acidic solution was only 0.58% at pH 2.1. Ultrasound irradiation (200 kHz, 200 W) was applied to oxidize 10 ppm of As(III) to As(V) at pH 2.2 for 60 min under various atmospheric conditions. Remarkably, the oxidation ratio of As(III) to As(V) is quite high (89.7%) at pH 2.2 in ambient atmosphere and is close to those obtained for Ar (95.3%) and O2 (95.9%) atmospheres. The As(III) removal ratio reached 94.5% after 60 min of irradiation. Therefore, goethite is a promising material for As adsorption using ultrasound oxidation in the acidic region in ambient atmosphere.
Seven new combinations in Phanera (Fabaceae: Caesalpinioideae: Cercideae)
Authors: Bandyopadhyay Subir , Ghoshal Partha Pratim
Published: June 2015

Seven new combinations in Phanera Lour. are made for species which were either described in Lasiobema (Korth.) Miq. or later transferred to Lasiobema from Bauhinia L.
The distribution of precipitation and the spread in tropical upper tropospheric temperature trends in CMIP5/AMIP simulations
Authors: Fueglistaler S. , Radley C. , Held I. M.
Published: June 2015

Reconciling observations and simulations of tropical upper tropospheric temperature trends remains an important problem in climate science. Examining atmospheric models running over observed sea surface temperatures (SSTs), Flannaghan et al. (2014) show that this reconciliation is affected by the SST data set used and that a precipitation‐weighted SST (PSST) is valuable in explaining this result. Here we show that even for Coupled Model Intercomparison Project Phase 5 Atmospheric Model Intercomparison Project (CMIP5 AMIP) simulations forced with identical SSTs, tropical upper tropospheric temperature trends across models (and between ensemble members) show a substantial spread (standard deviation ∼10% of the average trend). About 60% of this spread between ensemble means, as well as deviations from the ensemble means, can be explained by PSST calculated from the time‐evolving precipitation in each model run. Both PSST and atmospheric temperature trends show statistical evidence for systematic differences between models. We conclude that the response of precipitation patterns to changes in SST patterns is a significant source of uncertainty for tropical temperature trends.
An FDTD model of scattering from meteor head plasma
Authors: Marshall R. A. , Close S.
Published: June 2015

We have developed a three‐dimensional finite difference time domain (FDTD) model of scattering of radar waves from meteor head plasma. The model treats the meteor head plasma as a cold, collisional, and magnetized plasma, and solves Maxwell's equations and the Langevin equation simultaneously and self‐consistently in and around the plasma. We use this model to investigate scattering of radar waves from a meteor head (the “head echo”) under a range of plasma densities, meteor scale sizes, and wave frequencies. In this way we relate the radar cross section (RCS) to these variable parameters. We find that computed RCS disagrees with previous analytical theory at certain meteor sizes and densities, in some cases by over an order of magnitude. We find that the calculated meteor head RCS is monotonically related to the “overdense area” of the meteor, defined as the cross‐section area of the part of the meteor where the plasma frequency exceeds the wave frequency. These results provides a physical measure of the meteor size and density that can be inferred from measured RCS values from ground‐based radars. Meteoroid mass can then be inferred from the meteor plasma distribution using established methods.
Multicriteria evaluation of discharge simulation in Dynamic Global Vegetation Models
Authors: Yang Hui , Piao Shilong , Zeng Zhenzhong , Ciais Philippe , Yin Yi , Friedlingstein Pierre , Sitch Stephen , Ahlström Anders , Guimberteau Matthieu , Huntingford Chris , Levis Sam , Levy Peter E. , Huang Mengtian , Li Yue , Li Xiran , Lomas Mark R , Peylin Philippe , Poulter Ben , Viovy Nicolas , Zaehle Soenke , Zeng Ning , Zhao Fang , Wang Lei
Published: June 2015

In this study, we assessed the performance of discharge simulations by coupling the runoff from seven Dynamic Global Vegetation Models (DGVMs; LPJ, ORCHIDEE, Sheffield‐DGVM, TRIFFID, LPJ‐GUESS, CLM4CN, and OCN) to one river routing model for 16 large river basins. The results show that the seasonal cycle of river discharge is generally modeled well in the low and middle latitudes but not in the high latitudes, where the peak discharge (due to snow and ice melting) is underestimated. For the annual mean discharge, the DGVMs chained with the routing model show an underestimation. Furthermore, the 30 year trend of discharge is also underestimated. For the interannual variability of discharge, a skill score based on overlapping of probability density functions (PDFs) suggests that most models correctly reproduce the observed variability (correlation coefficient higher than 0.5; i.e., models account for 50% of observed interannual variability) except for the Lena, Yenisei, Yukon, and the Congo river basins. In addition, we compared the simulated runoff from different simulations where models were forced with either fixed or varying land use. This suggests that both seasonal and annual mean runoff has been little affected by land use change but that the trend itself of runoff is sensitive to land use change. None of the models when considered individually show significantly better performances than any other and in all basins. This suggests that based on current modeling capability, a regional‐weighted average of multimodel ensemble projections might be appropriate to reduce the bias in future projection of global river discharge.
PRYSM: An open‐source framework for PRoxY System Modeling, with applications to oxygen‐isotope systems
Authors: Dee S. , Emile‐Geay J. , Evans M. N. , Allam A. , Steig E. J. , Thompson D.M.
Published: June 2015

Paleoclimate observations constitute the only constraint on climate behavior prior to the instrumental era. However, such observations only provide indirect (proxy) constraints on physical variables. Proxy system models aim to improve the interpretation of such observations and better quantify their inherent uncertainties. However, existing models are currently scattered in the literature, making their integration difficult. Here, we present a comprehensive modeling framework for proxy systems, named PRYSM. For this initial iteration, we focus on water‐isotope based climate proxies in ice cores, corals, tree ring cellulose, and speleothem calcite. We review modeling approaches for each proxy class, and pair them with an isotope‐enabled climate simulation to illustrate the new scientific insights that may be gained from this framework. Applications include parameter sensitivity analysis, the quantification of archive‐specific processes on the recorded climate signal, and the quantification of how chronological uncertainties affect signal detection, demonstrating the utility of PRYSM for a broad array of climate studies.
Direct identification of the linear block in Wiener system
Authors: Wachel Paweł , Mzyk Grzegorz
Published: June 2015

In the paper, the linear component of the Wiener system is identified under poor knowledge about the static subsystem nonlinearity. Unlike most of other identification methods, the proposed approach allows to decompose the problem of the Wiener system identification into two simpler subproblems. The considered methodology is based on the observation that the impulse response of the dynamic subsystem is proportional to the multiple input single output mapping, directly related to the considered system. Although derivation of the method involves gradient and kernel least squares techniques, the resulting algorithm possesses explicit form and does not utilize any difficult computational procedures. The consistency of the method is proved, and sufficient conditions for algorithm's bandwidth selection are formulated. Practical aspects of the approach are discussed, and applicability of the method for small and moderate number of observations is examined numerically. Copyright © 2015 John Wiley & Sons, Ltd.
Disorder Control in Crystalline GeSb2Te4 Using High Pressure
Authors: Xu Ming , Zhang Wei , Mazzarello Riccardo , Wuttig Matthias
Published: June 2015

Electronic phase‐change memory devices take advantage of the different resistivity of two states, amorphous and crystalline, and the swift transitions between them in active phase‐change materials (PCMs). In addition to these two distinct phases, multiple resistive states can be obtained by tuning the atomic disorder in the crystalline phase with heat treatment, because the disorder can lead to the localization of the electronic states and, thus, hamper the electron transport. The goal of this work is to achieve and explore multiple disordered configurations in PCMs by applying high pressure. Large‐scale ab initio molecular dynamics simulations demonstrate that pressure can lower the energy barrier for the antisite migration in crystalline PCMs. The accumulation of these antisite atoms largely increases the compositional disorder, adding localized electronic states near the conduction band. The disorder‐induced electron localization triggered by pressure is a novel way to modulate the properties of materials. Furthermore, the random distortion of the lattice induced by the compositional disorder provides a new mechanism that contributes to the amorphization of crystalline PCMs at high pressure.
What Causes Firm Profitability Variation in the EU Food Industry? A Redux of Classical Approaches of Variance Decomposition
Authors: Hirsch Stefan , Schiefer Jan
Published: June 2015

Since the 1980s economic researchers have applied variance decomposition methods such as ANOVA or components‐of‐variance (COV) in order to determine the importance of different effects for firm profitability variation. Nevertheless, these studies either focus on entire manufacturing sectors or on the U.S. food sector. This article, therefore, aims to determine the sources of firm profitability variation for EU food processors using the classical approaches of hierarchical ANOVA and COV. The paper also highlights a lack of the hierarchical ANOVA effect introduction pattern that occurs throughout previous literature. The results suggest that firm‐related effects are the main profit driver while industry, year, and country effects are negligible. [EconLit citations: L10, L25, C33].
Sustainable process design by the process to planet framework
Authors: Hanes Rebecca J. , Bakshi Bhavik R.
Published: June 2015

Sustainable process design (SPD) problems combine a process design problem with life cycle assessment (LCA) to optimize process economics and life cycle environmental impacts. While SPD makes use of recent advances in process systems engineering and optimization, its use of LCA has stagnated. Currently, only process LCA is utilized in SPD, resulting in designs based on incomplete and potentially inaccurate life cycle information. To address these shortcomings, the multiscale process to planet (P2P) modeling framework is applied to formulate and solve the SPD problem. The P2P framework offers a more comprehensive analysis boundary than conventional SPD and greater modeling detail than advanced LCA methodologies. Benefits of applying this framework to SPD are demonstrated with an ethanol process design case study. Results show that current methods shift emissions outside the analysis boundary, while applying the P2P modeling framework results in environmentally superior process designs. Future extensions of the P2P framework are discussed. © 2015 American Institute of Chemical Engineers AIChE J, 61: 3320–3331, 2015
Mass‐transfer rate enhancement for CO2 separation by ionic liquids: Theoretical study on the mechanism
Authors: Xie Wenlong , Ji Xiaoyan , Feng Xin , Lu Xiaohua
Published: June 2015

To promote the development of ionic liquid (IL) immobilized sorbents and supported IL membranes (SILMs) for CO2 separation, the kinetics of CO2 absorption/desorption in IL immobilized sorbents was studied using a novel method based on nonequilibrium thermodynamics. It shows that the apparent chemical‐potential‐based mass‐transfer coefficients of CO2 were in three regions with three‐order difference in magnitude for the IL‐film thicknesses in microscale, 100 nm‐scale, and 10 nm‐scale. Using a diffusion‐reaction theory, it is found that by tailoring the IL‐film thickness from microscale to nanoscale, the process was altered from diffusion‐control to reaction‐control, revealing the inherent mechanism for the dramatic rate enhancement. The extension to SILMs shows that the significant improvement of CO2 flux can be obtained theoretically for the membranes with nanoscale IL‐films, which makes it feasible to implement CO2 separation by ILs with low investment cost. © 2015 American Institute of Chemical Engineers AIChE J, 61: 4437–4444, 2015
Shifts in subsistence type and its impact on the human skull's morphological integration
Authors: Paschetta Carolina , De Azevedo Soledad , González Marina , Quinto‐Sánchez Mirsha , Cintas Celia , Varela Hugo , Gómez‐Valdés Jorge , Sánchez‐Mejorada Gabriela , González‐José Rolando
Published: June 2015

Objective

Here we evaluate morphological integration patterns and magnitudes in different skull regions to detect if shifts in morphological integration are correlated to the appearance of more processed (softer) diets.

Methods

To do so, three transitional populations were analyzed, including samples from groups that inhabited the same geographical region and for which the evidence shows that major changes occurred in their subsistence mode. Ninety three‐dimensional landmarks were digitized on 357 skulls and used as the raw data to develop geometric morphometric analyses. The landmark coordinates were divided into several different regions of biomechanical interest, following a three‐level hierarchically nested scheme: the whole skull, further subdivided into neurocranium (divided into the vault and basicranium), the facial (divided into the lower and upper facial), and the masticatory apparatus (divided into alveolar, temporal, and temporo‐mandibular joint).

Results

Our results indicate that the morphological integration and variability patterns significantly vary across skull regions but are maintained across the transitions. The alveolar border and the lower facial are the regions manifesting greater value of morphological integration and variability, while the upper facial, the temporo‐mandibular joint, and the basicranium are highly integrated and poorly variable.

Conclusions

The transition to softer diets increased morphological variation across cranial regions that are more exposed to masticatory strains effects. Am. J. Hum. Biol. 28:118–128, 2016. © 2015 Wiley Periodicals, Inc.
Disabling low back pain associated with night shift duration: sleep problems as a potentiator
Authors: Takahashi Masaya , Matsudaira Ko , Shimazu Akihito
Published: June 2015

Background

We investigated how night shift duration and sleep problems were jointly associated with disabling low back pain (LBP) among workers in different occupations.

Methods

An online‐survey was conducted regarding work schedules, disabling LBP, sleep problems, and other relevant factors in 5,008 workers who were randomly selected from a market research panel. Multiple logistic regression analyses determined the joint associations of night shift duration (0 [permanent day shift], <8, 8–9.9, 10–15.9, ≥16 hr) and sleep problems (no, yes) with disabling LBP adjusted for potential confounders.

Results

A night shift ≥16 hr was associated with a significant increase in the likelihood of disabling LBP. The magnitude of this association was elevated when participants perceived sleep problems including both sleep duration and quality.

Conclusion

Associations between extended night shifts and disabling LBP became stronger in the presence of short or poor quality sleep. Am. J. Ind. Med. 58:1300–1310, 2015. © 2015 Wiley Periodicals, Inc.
Identification of a novel mutation in RIPK4 in a kindred with phenotypic features of Bartsocas‐Papas and CHAND syndromes
Authors: Gollasch Benjamin , Basmanav Fitnat Buket , Nanda Arti , Fritz Günter , Mahmoudi Hassnaa , Thiele Holger , Wehner Maria , Wolf Sabrina , Altmüller Janine , Nürnberg Peter , Frank Jorge , Betz Regina C.
Published: June 2015

Three children from an expanded consanguineous Kuwaiti kindred presented with ankyloblepharon, sparse and curly hair, and hypoplastic nails, suggestive of CHAND syndrome (OMIM 214350) that belongs to the heterogeneous spectrum of ectodermal dysplasias. After exclusion of pathogenic mutations in TP63 we performed homozygosity mapping, followed by exome sequencing of one affected individual. We initially identified three homozygous mutations in the linked region, located in PWP2, MX2 and RIPK4. Recently, mutations in RIPK4 have been reported in Bartsocas‐Papas syndrome (OMIM 263650) that shows overlapping clinical symptoms with the phenotype observed in the affected individuals studied here. Subsequent analysis of affected and non‐affected family members showed that mutation c.850G>A (p.Glu284Lys) in RIPK4 was in complete segregation with the disease phenotype, in accordance with an autosomal recessive inheritance pattern, thus supporting pathogenicity of this variant. Interestingly, however, our patients did not have cleft lip/palate, a common feature encountered in Bartsocas‐Papas syndrome. Whereas in Bartsocas‐Papas syndromes missense mutations are usually located within the serin/threonin kinase of RIPK4, the mutation detected in our family resides just outside of the kinase domain, which could explain the milder phenotype. Our data raise the question if CHAND syndrome indeed is a distinct entity. Alternatively, CHAND and Bartsocas‐Papas syndrome might be allelic disorders or RIPK4 mutations could confer varying degrees of phenotypic severity, depending on their localization within or outside functionally important domains. Our findings indicate that making an accurate diagnosis based only on the prevailing clinical symptoms is challenging. © 2015 Wiley Periodicals, Inc.
Copper‐Catalyzed Synthesis of Amino‐Substituted Polycyclic Aromatic Hydrocarbons by the Sequential Reaction between Aryl Alkynyl Carboxylic Acids and Amines
Authors: Choi Jinseop , Park Kyungho , Lim Jeongah , Jung Hyun Min , Lee Sunwoo
Published: June 2015

Amino‐substituted polycyclic aromatic hydrocarbons were obtained by the reaction between aryl alkynyl carboxylic acids and amines in the presence of a copper catalyst. The hydrocarbons were obtained in good yield without the need to isolate the 1,4‐diaryl‐1,3‐butadiyne intermediate. The best result was obtained using a combination of CuCl and Cu(OTf)2, and the reactions of cyclic and acyclic secondary amines afforded the desired products.
Synthesis and Optical Properties of α,β‐Unsaturated Ketones Bearing a Benzofuran Moiety
Authors: Nazir Rashid , Meiling Till T. , Cywiński Piotr J. , Gryko Daniel T.
Published: June 2015

Five π‐expanded α,β‐unsaturated ketones have been prepared from a strongly electron‐rich benzofuran derivative via Knoevenagel reaction and aldol condensation. The incorporation of two 6‐didodecylaminobenzofuran‐2‐yl groups at the periphery of D‐π‐A and D‐π‐A‐π‐D molecules resulted in dyes with excellent solubility in the majority of organic solvents. In contrast to the majority of α,β‐unsaturated ketones, these dyes emit relatively strongly in the red region with a fluorescence quantum yield up to 40 %. They also display strong solvatofluorochromism with emission shifting from 570 nm in toluene to 670 nm in CHCl3. Depending on the chemical structure, they two‐photon cross‐sections (σ2) are up to 1700 GM (1 GM=1050 cm4 s photon−1).
Horse kick injury mimicking a handle bar injury or a hidden speared injury
Authors: Oode Yasumasa , Maruyama Tetsuro , Kimura Masayuki , Fukunaga Toru , Omori Kazuhiko , Yanagawa Youichi
Published: June 2015

A 16‐year‐old male was transported to our emergency department after he was kicked in the abdomen by a horse. He was diagnosed with injury of the liver and abdominal rectus muscle, and was cured by observational treatment. An Ichushi search was undertaken to identify articles published from 1983 to 2013 using the key words “horse” and “trauma”. We found 13 cases that described horse‐related injuries and summarized these cases, including our case. There were 10 males, three females and one patient of an undescribed sex. The patients ranged in age from 16 to 58 years old, with an average age of 33 years. The injured sites were predominantly the face (mandible) and upper abdomen, indicating that a projecting part of the body may be more likely to be injured. Cardiac rupture, aortic head injury, or lethality induced by a horse kick have not been reported in Japan, but such injuries have been reported in other countries. Ten of 15 cases (67%) required surgical treatment for severe injuries. Horse kick injuries tend to be severe, because the transfer of energy from the end of the hoof, with a small cross‐sectional area, to a small field, leads to internal organic injuries that are more severe than predicted, similar to a handlebar injury. Accordingly, we advocate the close observation of patients with horse kick injuries, which may be regarded as being similar to blunt stab wounds or hidden speared injuries.
Negative pressure wound therapy‐assisted dermatotraction for the closure of large open wounds in a patient with non‐clostridial gas gangrene
Authors: Ishida Kenichiro , Noborio Mitsuhiro , Nishimura Tetsuro , Ieki Yohei , Shimahara Yumiko , Sogabe Taku , Ehara Naoki , Saoyama Yuki , Sadamitsu Daikai
Published: June 2015

Case

A 53‐year‐old woman developed septic shock associated with non‐clostridial gas gangrene. She presented to the emergency department with two large open wounds on both thighs and in her sacral region. Non‐enhanced computed tomography showed air density in contact with the right iliopsoas, which extended to the posterior compartment of the thigh. We made repeated efforts at surgical debridement of the wound with resection of necrotic tissues.

Outcome

Using negative pressure wound therapy‐assisted dermatotraction, the pus pockets and the wound dehiscence decreased in size. Using this method we were successful in achieving delayed closure without skin grafts.

Conclusion

Negative pressure wound therapy can be an effective treatment for large and infected open contoured wounds. Negative pressure wound therapy‐assisted dermatotraction might be beneficial for poorly healing, large, open wounds in patients in poor condition and with insufficient reserve to tolerate reconstructive surgery.
Palladium‐Catalyzed Direct CH Arylation of Isoxazoles at the 5‐Position
Authors: Shigenobu Masashi , Takenaka Kazuhiro , Sasai Hiroaki
Published: June 2015

A palladium‐catalyzed direct arylation of isoxazoles with aryl iodides has been achieved. The CH bond at the 5‐position is activated selectively to give coupling products in moderate to good yields. This direct arylation was applied to the synthesis of a spiro‐type chiral ligand, which proved to be most effective to the palladium‐catalyzed tandem cyclization of a dialkenyl alcohol.
Energetic Insight into the Formation of Solids from Aluminum Polyoxocations
Authors: Reusser Dana , Casey William H. , Navrotsky Alexandra
Published: June 2015

The ε‐Keggin [AlO4Al12(OH)24(H2O)12]7+ ion (AlAl127+) is a metastable precursor in the formation of aluminum oxyhydroxide solids. It also serves as a useful model for the chemistry of aluminous mineral surfaces. Herein we calculate the enthalpies of formation for this aqueous ion and its heterometal‐substituted forms, GaAl127+ and GeAl128+, using solution calorimetry. Rather than measuring the enthalpies of the MAl127/8+ ions directly from solution hydrolysis, we measured the metathesis reaction of the crystallized forms with barium chloride creating an aqueous aluminum solution monospecific in MAl127/8+. Then, the contributions to the heat of formation from the crystallized forms were subtracted using referenced states. When comparing the aqueous AlAl127+ ion to solid aluminum (oxy)‐hydroxide phases, we found that this ion lies closer in energy to solid phases than to aqueous aluminum monomers, thus explaining its role as a precursor to amorphous aluminum hydroxide phases.
Amino Azaxylylenes Photogenerated from o‐Amido Imines: Photoassisted Access to Complex Spiro‐Poly‐Heterocycles
Authors: Mukhina Olga A. , Kuznetsov Dmitry M. , Cowger Teresa M. , Kutateladze Andrei G.
Published: June 2015

Upon irradiation, cyclic imines containing o‐amido groups are shown to produce reactive intermediates, amino azaxylylenes, which undergo intramolecular cycloadditions to tethered unsaturated pendants to yield complex N,O‐heterocycles having an additional spiro‐connected nitrogen heterocyclic moiety. Modular assembly of the photoprecursors allows expeditious increase of the complexity of the target poly‐heterocyclic scaffolds with a minimal number of experimentally simple reaction steps. The photocyclization and subsequent postphotochemical transformations are accompanied by an increase of Lovering's fsp3 factor, thus producing unprecedented three‐dimensional molecular architectures, and offering extended sampling of chemical space.
Sb‐intercalated layered double hydroxides–poly(vinyl chloride) nanocomposites: Preparation, characterization, and thermal stability
Authors: Liu Shu‐Ting , Zhang Ping‐Ping , Yan Kang‐Kang , Zhang Yuan‐Hu , Ye Ying , Chen Xue‐Gang
Published: June 2015

In this study, a novel
‐intercalated layered double hydroxide (Sb‐LDH) was prepared by simultaneous recovering of LDH structures and intercalation of
into LDH layers. The prepared Sb‐LDH composites remain the hydrotalcite structure with layered geometry and show higher thermal property than that of LDH. When applied to poly(vinyl chloride) (PVC) composites, Sb‐LDH showed limited thermal stability for PVC at the early stage of thermal and thermooxidative degradation processes. However, Sb‐LDH could retard the thermal cracking of the carbonaceous conjugated polyene of PVC which may hinder further degradation, and the moderate amount of Sb‐LDH (1, 2, and 5 wt %) in PVC resin can retard the process of decarbonation and enhance char formation. Sb‐LDH also promoted the transparency of PVC but darkened the color. With the advantages of transparency promotion, high temperature resistance, and long‐term stability, the prepared Sb‐LDH is a potential thermal stabilizer for PVC resins. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42524.
Structure effect of thin film polypropylene view by dielectric spectroscopy and X‐ray diffraction: Application to dry type power capacitors
Authors: Kahouli Abdelkader , Gallot‐Lavallée Olivier , Rain Pascal , Lesaint Olivier , Heux Laurent , Guillermin Christophe , Lupin Jean‐Marc
Published: June 2015

This work reports on the relationship between structure and dielectric properties of biaxially oriented polypropylene. The morphology of semicrystalline bioriented isotactic polypropylene films is investigated using wide angle X‐ray diffraction and Polarized Optical Microscopy. A β‐orthorhombic structure, with a crystallinity ratio of about 46%, and “Crater” morphology of the β‐form is identified. Dielectric properties are measured by Broadband Dielectric Spectroscopy over a wide temperature range (−150 to 125°C). Since the dissipation factor of the PP is very low, special care was taken to obtain valid data. Two main relaxation processes are observed: a α‐relaxation peak associated to the glass transition temperature (Tg) at temperature about −7°C, and a broad β*‐relaxation at about −60°C, partly attributed to CH orientation. The variation of the dissipation factor versus sample thickness (from 3.8 to 11.8 µm) is correlated and partly explained by the increase of crystallinity ratio and lamella size at larger thicknesses. It comes out that the thinnest film seems perfectly meet the application requesting, namely lowest dissipation factor and highest permittivity. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42602.
Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient‐specific neural cells
Authors: Fernandes Tiago G. , Duarte Sofia T. , Ghazvini Mehrnaz , Gaspar Cláudia , Santos Diana C. , Porteira Ana R. , Rodrigues Gonçalo M. C. , Haupt Simone , Rombo Diogo M. , Armstrong Judith , Sebastião Ana M. , Gribnau Joost , Garcia‐Cazorla Àngels , Brüstle Oliver , Henrique Domingos , Cabral Joaquim M. S. , Diogo Maria Margarida
Published: June 2015

Standardization of culture methods for human pluripotent stem cell (PSC) neural differentiation can greatly contribute to the development of novel clinical advancements through the comprehension of neurodevelopmental diseases. Here, we report an approach that reproduces neural commitment from human induced pluripotent stem cells using dual‐SMAD inhibition under defined conditions in a vitronectin‐based monolayer system. By employing this method it was possible to obtain neurons derived from both control and Rett syndrome patients' pluripotent cells. During differentiation mutated cells displayed alterations in the number of neuronal projections, and production of Tuj1 and MAP2‐positive neurons. Although investigation of a broader number of patients would be required, these observations are in accordance with previous studies showing impaired differentiation of these cells. Consequently, our experimental methodology was proved useful not only for the generation of neural cells, but also made possible to compare neural differentiation behavior of different cell lines under defined culture conditions. This study thus expects to contribute with an optimized approach to study the neural commitment of human PSCs, and to produce patient‐specific neural cells that can be used to gain a better understanding of disease mechanisms.
Integrated cell and process engineering for improved transient production of a “difficult‐to‐express“ fusion protein by CHO cells
Authors: Johari Yusuf B. , Estes Scott D. , Alves Christina S. , Sinacore Marty S. , James David C.
Published: June 2015

Based on an optimized electroporation protocol, we designed a rapid, milliliter‐scale diagnostic transient production assay to identify limitations in the ability of Chinese hamster ovary (CHO) cells to produce a model “difficult‐to‐express” homodimeric Fc‐fusion protein, Sp35Fc, that exhibited very low volumetric titer and intracellular formation of disulfide‐bonded oligomeric aggregates post‐transfection. As expression of Sp35Fc induced an unfolded protein response in transfected host cells, we utilized the transient assay to compare, in parallel, multiple functionally diverse strategies to engineer intracellular processing of Sp35Fc in order to increase production and reduce aggregation as two discrete design objectives. Specifically, we compared the effect of (i) co‐expression of ER‐resident molecular chaperones (BiP, PDI, CypB) or active forms of UPR transactivators (ATF6c, XBP1s) at varying recombinant gene load, (ii) addition of small molecules known to act as chemical chaperones (PBA, DMSO, glycerol, betaine, TMAO) or modulate UPR signaling (PERK inhibitor GSK2606414) at varying concentration, (iii) a reduction in culture temperature to 32°C. Using this information, we designed a biphasic, Sp35Fc‐specific transient manufacturing process mediated by lipofection that utilized CypB co‐expression at an optimal Sp35Fc:CypB gene ratio of 5:1 to initially maximize transfected cell proliferation, followed by addition of a combination of PBA (0.5 mM) and glycerol (1% v/v) at the onset of stationary phase to maximize cell specific production and eliminate Sp35Fc aggregation. Using this optimal, engineered process transient Sp35Fc production was significantly increased sixfold over a 12 day production process with no evidence of disulfide‐bonded aggregates. Finally, transient production in clonally derived sub‐populations (derived from parental CHO host) screened for a heritably improved capability to produce Sp35Fc was also significantly improved by the optimized process, showing that protein‐specific cell/process engineering can provide a solution that exceeds the limits of genetic/functional diversity within heterogeneous host cell populations. Biotechnol. Bioeng. 2015;112: 2527–2542. © 2015 Wiley Periodicals, Inc.
Concurrent determination of olanzapine, risperidone and 9‐hydroxyrisperidone in human plasma by ultra performance liquid chromatography with diode array detection method: application to pharmacokinetic study
Authors: Siva Selva Kumar M. , Ramanathan M.
Published: June 2015

A simple and sensitive ultra‐performance liquid chromatography (UPLC) method has been developed and validated for simultaneous estimation of olanzapine (OLZ), risperidone (RIS) and 9‐hydroxyrisperidone (9‐OHRIS) in human plasma in vitro. The sample preparation was performed by simple liquid–liquid extraction technique. The analytes were chromatographed on a Waters Acquity H class UPLC system using isocratic mobile phase conditions at a flow rate of 0.3 mL/min and Acquity UPLC BEH shield RP18 column maintained at 40°C. Quantification was performed on a photodiode array detector set at 277 nm and clozapine was used as internal standard (IS). OLZ, RIS, 9‐OHRIS and IS retention times were found to be 0.9, 1.4, .1.8 and 3.1 min, respectively, and the total run time was 4 min. The method was validated for selectivity, specificity, recovery, linearity, accuracy, precision and sample stability. The calibration curve was linear over the concentration range 1–100 ng/mL for OLZ, RIS and 9‐OHRIS. Intra‐ and inter‐day precisions for OLZ, RIS and 9‐OHRIS were found to be good with the coefficient of variation <6.96%, and the accuracy ranging from 97.55 to 105.41%, in human plasma. The validated UPLC method was successfully applied to the pharmacokinetic study of RIS and 9‐OHRIS in human plasma. Copyright © 2015 John Wiley & Sons, Ltd.