bluuebunny/crossref_metadata_2025 huggingface dataset:
FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury
Authors: Alastrue-Agudo Ana , Rodriguez-Jimenez Francisco , Mocholi Eric , De Giorgio Francesca , Erceg Slaven , Moreno-Manzano Victoria
Published: January 2018

Spinal cord injury (SCI) suffers from a lack of effective therapeutic strategies. We have previously shown that individual therapeutic strategies, transplantation of ependymal stem/progenitor cells of the spinal cord after injury (epSPCi) or FM19G11 pharmacological treatment, induce moderate functional recovery after SCI. Here, the combination of treatments has been assayed for functional and histological analysis. Immediately after severe SCI, one million epSPCi were intramedullary injected, and the FM19G11 compound or dimethyl sulfoxide (DMSO) (as the vehicle control) was administrated via intrathecal catheterization. The combination of treatments, epSPCi and FM19G11, improves locomotor tasks compared to the control group, but did not significantly improve the Basso, Beattie, Bresnahan (BBB) scores for locomotor analysis in comparison with the individual treatments. However, the histological analysis of the spinal cord tissues, two months after SCI and treatments, demonstrated that when we treat the animals with both epSPCi and FM19G11, an improved environment for neuronal preservation was generated by reduction of the glial scar extension. The combinatorial treatment also contributes to enhancing the oligodendrocyte precursor cells by inducing the expression of Olig1 in vivo. These results suggest that a combination of therapies may be an exciting new therapeutic treatment for more efficient neuronal activity recovery after severe SCI.
Intraarticularly-Injected Mesenchymal Stem Cells Stimulate Anti-Inflammatory Molecules and Inhibit Pain Related Protein and Chondrolytic Enzymes in a Monoiodoacetate-Induced Rat Arthritis Model
Authors: Ichiseki Toru , Shimasaki Miyako , Ueda Yoshimichi , Ueda Shusuke , Tsuchiya Masanobu , Souma Daisuke , Kaneuji Ayumi , Kawahara Norio
Published: January 2018

Persistent inflammation is well known to promote the progression of arthropathy. mesenchymal stem cells (MSCs) have been shown to possess anti-inflammatory properties and tissue differentiation potency. Although the experience so far with the intraarticular administration of mesenchymal stem cell (MSC) to induce cartilage regeneration has been disappointing, MSC implantation is now being attempted using various surgical techniques. Meanwhile, prevention of osteoarthritis (OA) progression and pain control remain important components of the treatment of early-stage OA. We prepared a shoulder arthritis model by injecting monoiodoacetate (MIA) into a rat shoulder, and then investigated the intraarticular administration of MSC from the aspects of the cartilage protective effect associated with their anti-inflammatory property and inhibitory effect on central sensitization of pain. When MIA was administered in this rat shoulder arthritis model, anti-Calcitonin Gene Related Peptide (CGRP) was expressed in the joint and C5 spinal dorsal horn. Moreover, expression of A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5), a marker of joint cartilage injury, was similarly elevated following MIA administration. When MSC were injected intraarticularly after MIA, the expression of CGRP in the spinal dorsal horn was significantly deceased, indicating suppression of the central sensitization of pain. The expression of ADAMTS 5 in joint cartilage was also significantly inhibited by MSC administration. In contrast, a significant increase in the expression of TNF-α stimulated gene/protein 6 (TSG-6), an anti-inflammatory and cartilage protective factor shown to be produced and secreted by MSC intraarticularly, was found to extend to the cartilage tissue following MSC administration. In this way, the intraarticular injection of MSC inhibited the central sensitization of pain and increased the expression of the anti-inflammatory and cartilage protective factor TSG-6. As the least invasive conservative strategies possible are desirable in the actual clinical setting, the intraarticular administration of MSC, which appears to be effective for the treatment of pain and cartilage protection in early-stage arthritis, may achieve these aims.
Synthesized Heparan Sulfate Competitors Attenuate Pseudomonas aeruginosa Lung Infection
Authors: Lorè Nicola , Veraldi Noemi , Riva Camilla , Sipione Barbara , Spagnuolo Lorenza , De Fino Ida , Melessike Medede , Calzi Elisa , Bragonzi Alessandra , Naggi Annamaria , Cigana Cristina
Published: January 2018

Several chronic respiratory diseases are characterized by recurrent and/or persistent infections, chronic inflammatory responses and tissue remodeling, including increased levels of glycosaminoglycans which are known structural components of the airways. Among glycosaminoglycans, heparan sulfate (HS) has been suggested to contribute to excessive inflammatory responses. Here, we aim at (i) investigating whether long-term infection by Pseudomonas aeruginosa, one of the most worrisome threat in chronic respiratory diseases, may impact HS levels, and (ii) exploring HS competitors as potential anti-inflammatory drugs during P. aeruginosa pneumonia. P. aeruginosa clinical strains and ad-hoc synthesized HS competitors were used in vitro and in murine models of lung infection. During long-term chronic P. aeruginosa colonization, infected mice showed higher heparin/HS levels, evaluated by high performance liquid chromatography-mass spectrometry after selective enzymatic digestion, compared to uninfected mice. Among HS competitors, an N-acetyl heparin and a glycol-split heparin dampened leukocyte recruitment and cytokine/chemokine production induced by acute and chronic P. aeruginosa pneumonia in mice. Furthermore, treatment with HS competitors reduced bacterial burden during chronic murine lung infection. In vitro, P. aeruginosa biofilm formation decreased upon treatment with HS competitors. Overall, these findings support further evaluation of HS competitors as a novel therapy to counteract inflammation and infection during P. aeruginosa pneumonia.
The Evolving Treatment of Peripheral Arterial Disease through Guideline-Directed Recommendations
Authors: Morcos Ramez , Louka Boshra , Tseng Andrew , Misra Sanjay , McBane Robert , Esser Heidi , Shamoun Fadi
Published: January 2018

Peripheral arterial disease (PAD) refers to partial or complete occlusion of one or more non-coronary arteries that leads to compromised blood flow and ischemia. Numerous processes are involved in arterial stenosis, however, atherosclerosis remains the most common etiology. PAD constitutes a major health economic problem, and it is estimated that over 200 million people around the world suffer from PAD, with at least 20% having some degree of claudication. The purpose of this review is to compare and contrast the guidelines on PAD published in 2005, 2011 and 2016 in terms of new recommendations and level of evidence for practicing clinicians.
Acknowledgement to Reviewers of Journal of Manufacturing and Materials Processing in 2017
Authors:   JMMP Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that JMMP maintains high quality standards for its published papers. In 2017, a total of 22 papers were published in the journal.[...]
Novel PAMAM-PEG-Peptide Conjugates for siRNA Delivery Targeted to the Transferrin and Epidermal Growth Factor Receptors
Authors: Urbiola Koldo , Blanco-Fernández Laura , Ogris Manfred , Rödl Wolfgang , Wagner Ernst , Tros de Ilarduya Conchita
Published: January 2018

The transferrin (TfR) and epidermal growth factor receptors (EGFR) are known to be overexpressed on the surface of a wide variety of tumor cells. Therefore, the peptides B6 (TfR specific) and GE11 (targeted to the EGFR) were linked to the PAMAM (polyamidoamine) structure via a polyethylenglycol (PEG) 2 kDa chain with the aim of improving the silencing capacity of the PAMAM-based dendriplexes. The complexes showed an excellent binding capacity to the siRNA with a maximal condensation at nitrogen/phosphate (N/P) 2. The nanoparticles formed exhibited hydrodynamic diameters below 200 nm. The zeta potential was always positive, despite the complexes containing the PEG chain in the structure showing a drop of the values due to the shielding effect. The gene silencing capacity was assayed in HeLa and LS174T cells stably transfected with the eGFPLuc cassette. The dendriplexes containing a specific anti luciferase siRNA, assayed at different N/P ratios, were able to mediate a mean decrease of the luciferase expression values of 14% for HeLa and 20% in LS174T cells, compared to an unspecific siRNA-control. (p < 0.05). In all the conditions assayed, dendriplexes resulted to be non-toxic and viability was always above 75%.
A Note on the Equivalence of Fractional Relaxation Equations to Differential Equations with Varying Coefficients
Authors: Mainardi Francesco
Published: January 2018

In this note, we show how an initial value problem for a relaxation process governed by a differential equation of a non-integer order with a constant coefficient may be equivalent to that of a differential equation of the first order with a varying coefficient. This equivalence is shown for the simple fractional relaxation equation that points out the relevance of the Mittag–Leffler function in fractional calculus. This simple argument may lead to the equivalence of more general processes governed by evolution equations of fractional order with constant coefficients to processes governed by differential equations of integer order but with varying coefficients. Our main motivation is to solicit the researchers to extend this approach to other areas of applied science in order to have a deeper knowledge of certain phenomena, both deterministic and stochastic ones, investigated nowadays with the techniques of the fractional calculus.
The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling
Authors: Kuo Liang-Mou , Chen Po-Jen , Sung Ping-Jyun , Chang Yu-Chia , Ho Chun-Ting , Wu Yi-Hsiu , Hwang Tsong-Long
Published: January 2018

The activation of hepatic stellate cells (HSCs) is a significant phenomenon during the pathogenesis of liver disorders, including liver cirrhosis and fibrosis. Here, we identified that the extract from a gorgonian coral Pinnigorgia sp. (Pin) induced apoptosis of HSC-T6 cells. Pin inhibited the viability of HSC-T6 cells and increased their subG1 population, DNA fragmentation, caspase-3 activation, and reactive oxygen species (ROS) production in a concentration-dependent manner. The Pin-induced ROS generation and apoptotic effects were significantly reversed by a thiol antioxidant, N-acetylcysteine (NAC). Additionally, Pin induced ERK/JNK phosphorylation and pharmacological inhibition of ERK/JNK rescued the Pin-induced cell death. Pin-activated ERK/JNK were significantly reduced after the administration of NAC; however, the inhibition of ERK/JNK failed to change the Pin-induced ROS production. Similarly, pinnigorgiol A, a pure compound isolated from Pin, elicited ROS production and apoptosis in HSC-T6 cells. The pinnigorgiol A-induced apoptosis was retrained by NAC. Together, it appears that Pin leads to apoptosis in HSC-T6 cells through ROS-mediated ERK/JNK signaling and caspase-3 activation. Pinnigorgiol A serves as a bioactive compound of Pin and may exhibit therapeutic potential by clearance of HSCs.
Mechanism of Solder Joint Cracks in Anisotropic Conductive Films Bonding and Solutions: Delaying Hot-Bar Lift-Up Time and Adding Silica Fillers
Authors: Zhang Shuye , Yang Ming , Jin Mingliang , Huang Wen-Can , Lin Tiesong , He Peng , Lin Panpan , Paik Kyung-Wook
Published: January 2018

Micron sizes solder metallurgical joints have been applied in a thin film application of anisotropic conductive film and benefited three general advantages, such as lower joint resistance, higher power handling capability, and reliability, when compared with pressure based contact of metal conductor balls. Recently, flex-on-board interconnection has become more and more popular for mobile electronic applications. However, crack formation of the solder joint crack was occurred at low temperature curable acrylic polymer resins after bonding processes. In this study, the mechanism of SnBi58 solder joint crack at low temperature curable acrylic adhesive was investigated. In addition, SnBi58 solder joint cracks can be significantly removed by increasing the storage modulus of adhesives instead of coefficient of thermal expansion. The first approach of reducing the amount of polymer rebound can be achieved by using an ultrasonic bonding method to maintain a bonding pressure on the SnBi58 solder joints cooling to room temperature. The second approach is to increase storage modulus of adhesives by adding silica filler into acrylic polymer resins to prevent the solder joint from cracking. Finally, excellent acrylic based SnBi58 solder joints reliability were obtained after 1000 cycles thermal cycling test.
Dielectrophoresis Testing of Nonlinear Viscoelastic Behaviors of Human Red Blood Cells
Authors: Qiang Yuhao , Liu Jia , Du E
Published: January 2018

Dielectrophoresis in microfluidics provides a useful tool to test biomechanics of living cells, regardless of surface charges on cell membranes. We have designed an experimental method to characterize the nonlinear viscoelastic behaviors of single cells using dielectrophoresis in a microfluidic channel. This method uses radio frequency, low voltage excitations through interdigitated microelectrodes, allowing probing multiple cells simultaneously with controllable load levels. Dielectrophoretic force was calibrated using a triaxial ellipsoid model. Using a Kelvin–Voigt model, the nonlinear shear moduli of cell membranes were determined from the steady-state deformations of red blood cells in response to a series of electric field strengths. The nonlinear elastic moduli of cell membranes ranged from 6.05 µN/m to up to 20.85 µN/m, which were identified as a function of extension ratio, rather than the lumped-parameter models as reported in the literature. Value of the characteristic time of the extensional recovery of cell membranes initially deformed to varied extent was found to be about 0.14 s. Shear viscosity of cell membrane was estimated to be 0.8–2.9 (µN/m)·s. This method is particularly valuable for rapid, non-invasive probing of mechanical properties of living cells.
Enzymatic Preparation of 2,5-Furandicarboxylic Acid (FDCA)—A Substitute of Terephthalic Acid—By the Joined Action of Three Fungal Enzymes
Authors: Karich Alexander , Kleeberg Sebastian , Ullrich René , Hofrichter Martin
Published: January 2018

Enzymatic oxidation of 5-hydroxymethylfurfural (HMF) and its oxidized derivatives was studied using three fungal enzymes: wild-type aryl alcohol oxidase (AAO) from three fungal species, wild-type peroxygenase from Agrocybe aegerita (AaeUPO), and recombinant galactose oxidase (GAO). The effect of pH on different reaction steps was evaluated and apparent kinetic data (Michaelis-Menten constants, turnover numbers, specific constants) were calculated for different enzyme-substrate ratios and enzyme combinations. Finally, the target product, 2,5-furandicarboxylic acid (FDCA), was prepared in a multi-enzyme cascade reaction combining three fungal oxidoreductases at micro-scale. Furthermore, an oxidase-like reaction is proposed for heme-containing peroxidases, such as UPO, horseradish peroxidase, or catalase, causing the conversion of 5-formyl-2-furancarboxylic acid into FDCA in the absence of exogenous hydrogen peroxide.
C–O Stable Isotopes Geochemistry of Tunisian Nonsulfide Zinc Deposits: A First Look
Authors: Garnit Hechmi , Boni Maria , Buongiovanni Giuliana , Arfè Giuseppe , Mondillo Nicola , Joachimski Michael , Bouhlel Salah , Balassone Giuseppina
Published: January 2018

A preliminary C–O stable isotopes geochemical characterization of several nonsulfide Zn-Pb Tunisian deposits has been carried out, in order to evidence the possible differences in their genesis. Nonsulfide ores were sampled from the following deposits: Ain Allegua, Jebel Ben Amara, Jebel Hallouf (Nappe Zone), Djebba, Bou Grine, Bou Jaber, Fedj el Adoum, Slata Fer (Diapir Zone), Jebel Ressas, Jebel Azreg, Mecella (North South Axis Zone), Jebel Trozza, Sekarna (Graben Zone). After mineralogical investigation of selected specimens, the C–O stable isotopic study was carried out on smithsonite, hydrozincite, cerussite and calcite. The data have shown that all the carbonate generations in the oxidized zones of Ain Allegua and Jebel Ben Amara (Nappe Zone), Bou Jaber, Bou Grine and Fedj el Adoum (Diapir Zone), Mecella and Jebel Azreg (North South Zone) have a supergene origin, whereas the carbonates sampled at Sekarna (Graben Zone) (and in limited part also at Bou Jaber) precipitated from thermal waters at moderately high temperature. Most weathering processes that controlled the supergene alteration of the Zn-Pb sulfide deposits in Tunisia had probably started in the middle to late Miocene interval and at the beginning of the Pliocene, both periods corresponding to two distinct tectonic pulses that produced the exhumation of sulfide ores, but the alteration and formation of oxidized minerals could have also continued through the Quaternary. The isotopic characteristics associated with the weathering processes in the sampled localities were controlled by the different locations of the sulfide protores within the tectonic and climatic zones of Tunisia during the late Tertiary and Quaternary.
Contribution of Secondary Metabolites to the Gastroprotective Effect of Aqueous Extract of Ximenia americana L. (Olacaceae) Stem Bark in Rats
Authors: Aragão Ticiana , Prazeres Lady , Brito Samara , Neto Pedro , Rolim Larissa , Almeida Jackson , Caldas Germana , Wanderley Almir
Published: January 2018

Ximenia americana L. (Olacaceae) is used in ethnomedicine as cicatrizant and for the treatment of gastric disorders. This study identified the chemical constituents of the aqueous extract of X. americana (XaAE) and evaluated its antiulcerogenic activity. After lyophilization, XaAE was analyzed by liquid chromatography-mass spectrometry (LC-MS) and its antiulcerogenic effect was evaluated in acute gastric lesions induced by ethanol, acidified ethanol, and indomethacin. Antisecretory action, mucus production and the participation of sulfhydryl groups (–SH) and nitric oxide (NO) were also investigated. The chromatographic analysis identified procyanidins B and C and catechin/epicatechin as major compounds. Oral administration of XaAE (100, 200 and 400 mg/kg) inhibited the gastric lesions induced by ethanol (76.1%, 77.5% and 100%, respectively), acidified ethanol (44.9%, 80.6% and 94.9%, respectively) and indomethacin (56.4%, 52.7% and 64.9%, respectively). XaAE reduced gastric contents and acidity (51.4% and 67.7%, respectively) but did not alter the production of gastric mucus. The reduction of the -SH and NO groups promoted by N-ethylmaleimide (NEM) and Nω-nitro-l-arginine-methyl-ester (L-NAME) respectively, reduced the gastroprotective effect of XaAE. In conclusion, XaAE has gastroprotective activity mediated in part by -SH, NO and antisecretory activity. This antiulcer action was initially correlated to its major constituents, procyanidins B and C and catechin/epicatechin.
A Tri-O-Bridged Diels-Alder Adduct from Cortex Mori Radicis
Authors: Lu An-Qi , Chen Ming-Hua , Gao Jie , Wang Lu , Yang Han-Yu , Li Lan , Zhang Bo , He Hao-Ke , Wang Su-Juan
Published: January 2018

Sanggenon X, an unusual tri-O-bridged Diels-Alder adduct, was isolated from Cortex Mori Radicis. Its structure was established by spectroscopic analysis, including NMR and HR-MS (High Resolution Mass Spectrometry). Sanggenon X contained three O-bridged rings, where the oxygenated bridgeheads were all quaternary carbons. Chemical methylation was carried out to deduce the linkages of the three O-bridges. The absolute configuration was determined by calculating the ECD (Electronic Circular Dichroism) using the TDDFT (Time-Dependent Density Functional Theory) method. Sanggenon X showed significant antioxidant activity against Fe2+-Cys-induced lipid peroxidation in rat liver microsomes, and was as effective as the positive control, curcumin.
Maternal High Fructose Intake Increases the Vulnerability to Post-Weaning High-Fat Diet-Induced Programmed Hypertension in Male Offspring
Authors: Tain You-Lin , Lee Wei-Chia , Wu Kay , Leu Steve , Chan Julie
Published: January 2018

Widespread consumption of high-fructose and high-fat diets relates to the global epidemic of hypertension. Hypertension may originate from early life by a combination of prenatal and postnatal nutritional insults. We examined whether maternal high-fructose diet increases vulnerability to post-weaning high-fructose or high-fat diets induced hypertension in adult offspring and determined the underlying mechanisms. Pregnant Sprague-Dawley rats received regular chow (ND) or chow supplemented with 60% fructose (HFR) during the entire pregnancy and lactation periods. Male offspring were onto either the regular chow, 60% fructose, or high-fat diet (HFA) from weaning to 12 weeks of age and assigned to four groups: ND/ND, HFR/ND, HFR/HFR, and HFR/HFA. Maternal high-fructose diet exacerbates post-weaning high-fat diet-induced programmed hypertension. Post-weaning high-fructose and high-fat diets similarly reduced Sirt4, Prkaa2, Prkag2, Ppara, Pparb, and Ppargc1a mRNA expression in offspring kidneys exposed to maternal high-fructose intake. Additionally, post-weaning high-fat diet significantly reduced renal mRNA levels of Ulk1, Atg5, and Nrf2 and induced greater oxidative stress than did high-fructose diet. Although maternal high-fructose intake increases soluble epoxide hydrolase (SEH) expression in the kidney, which was restored by post-weaning high-fructose and high-fat diets. Maternal high-fructose diet programs differential vulnerability to developing hypertension in male offspring in response to post-weaning high-fructose and high-fat diets. Our data implicated that specific therapy targeting on nutrient sensing signals, oxidative stress, and SEH may be a promising approach to prevent hypertension in children and mothers exposed to high-fructose and high-fat consumption.
Dietary Patterns in European and Brazilian Adolescents: Comparisons and Associations with Socioeconomic Factors
Authors: Borges Camila , Slater Betzabeth , Santaliestra-Pasías Alba , Mouratidou Theodora , Huybrechts Inge , Widhalm Kurt , Gottrand Frédéric , Manios Yannis , Jimenez-Pavón David , Valtueña Jara , Le Donne Cinzia , Marcos Ascensión , Molnar Dénes , Castillo Manuel , De Henauw Stefaan , Moreno Luis
Published: January 2018

Associations between dietary patterns (DP) and socioeconomic factors have been little explored in adolescents. The aim of this study was to identify DP in European and Brazilian adolescents and to investigate their associations with a range of socioeconomic indicators. Adolescents from the HELENA-study and the Household Budget Survey were analyzed. Factor analysis was used to obtain DP. Linear regression was used to examine the association between DP and SES. In Europeans, the Western DP was associated with low education of the mother, high socioeconomic status (boys), older age (boys), and living in cities of the Northern Europe; in Brazilians, the Western DP was associated with high secondary education of the mother, high socioeconomic status and living in Southern areas of the country. The Traditional European DP, in both genders, was associated with high secondary education of the mother and inversely associated with a high socioeconomic status; the Traditional Brazilian DP, was associated with university level education of the mother and older age (boys). The association between DP and socioeconomic factors is relevant for the understanding of food-related practices and highlight the importance of performing a complete assessment of the socioeconomic influence in adolescent’s DP from developed and developing countries.
Facile and Rapid Formation of Giant Vesicles from Glass Beads
Authors: Tanasescu Radu , Mettal Ute , Colom Adai , Roux Aurélien , Zumbuehl Andreas
Published: January 2018

Giant vesicles (GVs) are widely-used model systems for biological membranes. The formulation of these vesicles, however, can be problematic and artifacts, such as degraded molecules or left-over oil, may be present in the final liposomes. The rapid formulation of a high number of artifact-free vesicles of uniform size using standard laboratory equipment is, therefore, highly desirable. Here, the gentle hydration method of glass bead-supported thin lipid films has been enhanced by adding a vortexing step. This led to the formulation of a uniform population of giant vesicles. Batches of glass beads coated with different lipids can be combined to produce vesicles of hybrid lipid compositions. This method represents a stable approach to rapidly generate giant vesicles.
Thermal, Mechanical and Optical Features of Aluminosilicate-Coated Cotton Textiles via the Crosslinking Method
Authors: Ojstršek Alenka , Hribernik Silvo , Fakin Darinka
Published: January 2018

The presented study focuses on the development of a pad-dry-thermofix functional coating process using a mixture of microporous aluminosilicate particles in diverse bath formulations to impart UV-ray-blocking, thermal stability and easy-care properties to the cotton fabric. The results of Scanning Electron Microscopy (SEM) and X-ray powder Diffraction (XRD) revealed the presence of three different types of zeolites within the examined sample, i.e., the largest amount being zeolite A, followed by the zeolite X, and the zeolite ZSM-5. The surface characterization results of zeolite-coated/cross-linked textiles provided evidence of acceptable UV-ray-blocking properties and increased thermal stability, as well as enhanced tensile strength and breaking tenacity without considerably decreasing the whiteness degree. Moreover, the dry crease recovery angle increased for the cotton fabric cross-linked via an mDMDHEU, and decreased significantly using 30 g/L zeolites negatively influencing qualitative values. TG/DTA results have proven the enlarged thermal stability of aluminosilicate-coated cotton, although combustion was not prevented.
Development of Focusing Plasma Mirrors for Ultraintense Laser-Driven Particle and Radiation Sources
Authors: Wilson Robbie , King Martin , Gray Ross , Carroll David , Dance Rachel , Butler Nicholas , Armstrong Chris , Hawkes Steve , Clarke Robert , Robertson David , Bourgenot Cyril , Neely David , McKenna Paul
Published: January 2018

Increasing the peak intensity to which high power laser pulses are focused can open up new regimes of laser-plasma interactions, resulting in the acceleration of ions to higher energies and more efficient generation of energetic photons. Low f-number focusing plasma mirrors, which re-image and demagnify the laser focus, provide an attractive approach to producing higher intensities, without requiring significant changes to the laser system. They are small, enhance the pulse intensity contrast and eliminate the requirement to expose expensive optics directly to target debris. We report on progress made in a programme of work to design, manufacture and optimise ellipsoidal focusing plasma mirrors. Different approaches to manufacturing these innovative optics are described, and the results of characterisation tests are presented. The procedure developed to align the optics is outlined, together with initial results from their use with a petawatt-level laser.
Matěj of Janov: Corpus Mysticum, Communionem, and the Lost Treatise of His Regulae
Authors: Lahey Stephen
Published: January 2018

The Bohemian theologian Matěj of Janov (d.1393) is little known outside of Czech Hussite scholarship, yet his Regulae Veteris et Novi Testamentum is arguably as important an influence on the genesis and development of Hussitism, as is the thought of John Wyclif. The chief Hussite theologian Jakoubek of Střibro relied on his works, and his emphasis on the need for daily Eucharist for all Christians seems to have been central to the utraquist ideal central to Hussitism. This article describes the structure and content of Matěj’s Regulae, a carefully constructed sustained argument of the threat of Antichrist facing the church, and the nature of the reforms needed to respond to them. The editions of Kybal (1908–1926) and Nechutová (1993) present the extant books of the Regulae, but Book Two treatise 2 appears to have been lost. Based on my argument for the overall structure of the Regulae, I attempt to reconstruct the contents of this book, which I will argue is directly related to Matěj’s very high regard for his predecessor, the preacher Jan Milič of Kromeřiž.
The Canonical Black Body: Alternative African American Religions and the Disruptive Politics of Sacrality
Authors: Tucker Edmonds Joseph
Published: January 2018

“The Canonical Black Body” argues that central to the study of African American religions is a focus on the black body and the production and engagement of canons on the sacred black body within the black public sphere. Furthermore, this essay suggests that, by paying attention to alternative African American religions in the twentieth century, we can better engage the relationship between African American religion and the long history of creating these canons on the black body, debating their relationship to black freedom, and circulating the canons to contest the oppressive, exclusive practices of modern democracy. Through a critical engagement of the fields of Black Theology and New Religious Movements and using the resources offered by Delores Williams’ accounts of variety and experience and Vincent Wimbush’s category of signifying, this essay will argue for how a return to the body provides resources and tools for not only theorizing African American religions but thinking about the production and creation of competing black publics, including the important role of alternative black sacred publics.
Romantism, Amazement, Imagination—A trias religiosa
Authors: Van Praag Herman
Published: January 2018

To wonder is a gift of the romanticist in particular. Wonder seeks explanation. If reason doesn’t provide that, imagination provides a way out. One imagines a transcendental world of which the God-idea may become the central point and the explanatory model of that that invoked wonder. The God-idea implies wonder, wonder that live exists, that things exist at all. Wonder promotes religiosity—i.c., the need to provide life with a vertical dimension—and religiosity facilitates, in its turn, wonder. Thus the circle is closed: romanticism, wonder, imagination, religiosity, wonder. A circle providing life with an important bonus, i.e., sense, meaning with a supernatural signature. This augments the chance that hope will be preserved, even as dark clouds begin to hover above one’s life.
Performance and Requirements of GEO SAR Systems in the Presence of Radio Frequency Interferences
Authors: Li Yuanhao , Monti Guarnieri Andrea , Hu Cheng , Rocca Fabio
Published: January 2018

Geosynchronous Synthetic Aperture Radar (GEO SAR) is a possible next generation SAR system, which has the excellent performance of less than one-day revisit and hundreds of kilometres coverage. However, Radio Frequency Interference (RFI) is a serious problem, because the specified primary allocation frequencies are shared by the increasing number of microwave devices. More seriously, as the high orbit of GEO SAR makes the system have a very large imaging swath, the RFI signals all over the illuminated continent will interfere and deteriorate the GEO SAR signal. Aimed at the RFI impact in GEO SAR case, this paper focuses on the performance evaluation and the system design requirement of GEO SAR in the presence of RFI impact. Under the RFI impact, Signal-to-Interference-plus-Noise Ratio (SINR) and the required power are theoretically deduced both for the ground RFI and the bistatic scattering RFI cases. Based on the theoretical analysis, performance evaluations of the GEO SAR design examples in the presence of RFI are conducted. The results show that higher RFI intensity and lower working frequency will make the GEO SAR have a higher power requirement for compensating the RFI impact. Moreover, specular RFI bistatic scattering will give rise to the extremely serious impact on GEO SAR, which needs incredible power requirements for compensations. At last, real RFI signal behaviours and statistical analyses based on the SMOS satellite, Beidou-2 navigation satellite and Sentinel-1 A data have been given in the appendix.
A Novel Attitude Determination System Aided by Polarization Sensor
Authors: Zhi Wei , Chu Jinkui , Li Jinshan , Wang Yinlong
Published: January 2018

This paper aims to develop a novel attitude determination system aided by polarization sensor. An improved heading angle function is derived using the perpendicular relationship between directions of E-vector of linearly polarized light and solar vector in the atmospheric polarization distribution model. The Extended Kalman filter (EKF) with quaternion differential equation as a dynamic model is applied to fuse the data from sensors. The covariance functions of filter process and measurement noises are deduced in detail. The indoor and outdoor tests are conducted to verify the validity and feasibility of proposed attitude determination system. The test results showed that polarization sensor is not affected by magnetic field, thus the proposed system can work properly in environments containing the magnetic interference. The results also showed that proposed system has higher measurement accuracy than common attitude determination system and can provide precise parameters for Unmanned Aerial Vehicle (UAV) flight control. The main contribution of this paper is implementation of the EKF for incorporating the self-developed polarization sensor into the conventional attitude determination system. The real-world experiment with the quad-rotor proved that proposed system can work in a magnetic interference environment and provide sufficient accuracy in attitude determination for autonomous navigation of vehicle.
Blockchain Based Decentralized Management of Demand Response Programs in Smart Energy Grids
Authors: Pop Claudia , Cioara Tudor , Antal Marcel , Anghel Ionut , Salomie Ioan , Bertoncini Massimo
Published: January 2018

In this paper, we investigate the use of decentralized blockchain mechanisms for delivering transparent, secure, reliable, and timely energy flexibility, under the form of adaptation of energy demand profiles of Distributed Energy Prosumers, to all the stakeholders involved in the flexibility markets (Distribution System Operators primarily, retailers, aggregators, etc.). In our approach, a blockchain based distributed ledger stores in a tamper proof manner the energy prosumption information collected from Internet of Things smart metering devices, while self-enforcing smart contracts programmatically define the expected energy flexibility at the level of each prosumer, the associated rewards or penalties, and the rules for balancing the energy demand with the energy production at grid level. Consensus based validation will be used for demand response programs validation and to activate the appropriate financial settlement for the flexibility providers. The approach was validated using a prototype implemented in an Ethereum platform using energy consumption and production traces of several buildings from literature data sets. The results show that our blockchain based distributed demand side management can be used for matching energy demand and production at smart grid level, the demand response signal being followed with high accuracy, while the amount of energy flexibility needed for convergence is reduced.
Recent Advances in Electrochemical Biosensors Based on Enzyme Inhibition for Clinical and Pharmaceutical Applications
Authors: El Harrad Loubna , Bourais Ilhame , Mohammadi Hasna , Amine Aziz
Published: January 2018

A large number of enzyme inhibitors are used as drugs to treat several diseases such as gout, diabetes, AIDS, depression, Parkinson’s and Alzheimer’s diseases. Electrochemical biosensors based on enzyme inhibition are useful devices for an easy, fast and environment friendly monitoring of inhibitors like drugs. In the last decades, electrochemical biosensors have shown great potentials in the detection of different drugs like neostigmine, ketoconazole, donepezil, allopurinol and many others. They attracted increasing attention due to the advantage of being high sensitive and accurate analytical tools, able to reach low detection limits and the possibility to be performed on real samples. This review will spotlight the research conducted in the past 10 years (2007–2017) on inhibition based enzymatic electrochemical biosensors for the analysis of different drugs. New assays based on novel bio-devices will be debated. Moreover, the exploration of the recent graphical approach in diagnosis of reversible and irreversible inhibition mechanism will be discussed. The accurate and the fast diagnosis of inhibition type will help researchers in further drug design improvements and the identification of new molecules that will serve as new enzyme targets.
Engineering Properties of Self-Consolidating Lightweight Aggregate Concrete and Its Application in Prestressed Concrete Members
Authors: Chen How-Ji , Wu Kuo-Cheng , Tang Chao-Wei , Huang Chung-Ho
Published: January 2018

Self-consolidating lightweight aggregate concrete (SCLC) is a highly flowable and lightweight concrete. In this study, the properties of SCLC and prestressed SCLC members were tested and compared with those made of normal-weight self-consolidating concrete (SCC). The test results show that SCLC can be used for prestressed concrete members. The use of lightweight aggregates with a particle density larger than 1100 kg/m3 can avoid the serious segregation of fresh concrete. In addition, the SCLC designed in this study can meet most of the SCC Rank 2 test standards, except for the V-funnel test. The water contained in the lightweight aggregates supplied sustained curing, so the level of drying shrinkage of the SCLC was lower than that of the conventional SCC. However, the level of creep of the SCLC was higher than that of the conventional SCC, because normal-weight aggregates are more able to inhibit the change of the concrete’s volume. On-site test results show that after 180 days of prestressing, the prestress loss was about 5.35–6.83% for the full-size SCLC members, which was smaller than that for the conventional SCC members (about 8.19–9.06% loss).
Managing Sustainable Use of Antibiotics—The Role of Trust
Authors: Robertson Felicia , Jagers Sverker , Rönnerstrand Björn
Published: January 2018

Human overuse of antibiotics is the main driver of antibiotic resistance. Thus, more knowledge about factors that promote sustainable antibiotic use is urgently needed. Based upon findings from the management of other sustainability and collective action dilemmas, we hypothesize that interpersonal trust is crucial for people’s propensity to cooperate for the common objective. The aim of this article is to further our understanding of people’s antibiotic consumption by investigating if individuals’ willingness to voluntarily abstain from antibiotic use is linked to interpersonal trust. To fulfill the aim, we implement two empirical investigations. In the first part, we use cross-section survey data to investigate the link between interpersonal trust and willingness to abstain from using antibiotics. The second part is based on a survey experiment in which we study the indirect effect of trust on willingness to abstain from using antibiotics by experimentally manipulating the proclaimed trustworthiness of other people to abstain from antibiotics. We find that interpersonal trust is linked to abstemiousness, also when controlling for potential confounders. The survey experiment demonstrates that trustworthiness stimulates individuals to abstain from using antibiotics. In conclusion, trust is an important asset for preserving effective antibiotics for future generations, as well as for reaching many of the United Nations’ Sustainable Development Goals.
Owning or Outsourcing? Strategic Choice on Take-Back Operations for Third-Party Remanufacturing
Authors: Yan Wei , Li Hengyu , Chai Junwu , Qian Zhifeng , Chen Hong
Published: January 2018

Despite the remanufacturing process having demonstrated economic, social, and environmental benefits, many original equipment manufacturers (OEMs) have not engaged in the remanufacturing process themselves, as they often outsource it to a third party. In practice, such outsourcing usually involves two different options/modes for OEMs with consideration of take-back operations: (1) owning the reverse channel and collecting cores directly (Model D) or (2) outsourcing these operations to a third-party remanufacturer (TPR) and collecting cores indirectly (Model I). However, this raises the important question of whether OEMs should also outsource their reverse channels to third-party remanufacturers when outsourcing remanufacturing. Furthermore, there needs to be an investigation of which method is more beneficial in terms of economic, social, and environmental outcomes. This paper uses modelling to investigate the costs and benefits of these options in terms of sustainability. We found that, compared to Model I, the OEM conducting take-back operations itself can achieve the overall better outcomes for all economic, social, and environmental situations.
The Asymmetry is Derived from Mechanical Interlocking of Achiral Axle and Achiral Ring Components –Syntheses and Properties of Optically Pure [2]Rotaxanes–
Authors: Hirose Keiji , Ukimi Masaya , Ueda Shota , Onoda Chie , Kano Ryohei , Tsuda Kyosuke , Hinohara Yuko , Tobe Yoshito
Published: January 2018

Rotaxanes consisting of achiral axle and achiral ring components can possess supramolecular chirality due to their unique geometrical architectures. To synthesize such chiral rotaxanes, we adapted a prerotaxane method based on aminolysis of a metacyclophane type prerotaxane that had planar chirality, which is composed of an achiral stopper unit and a crown ether type ring component. The prerotaxanes were well resolved using chiral HPLC into a pair of enantiomerically pure prerotaxanes, which were transferred into corresponding chiral rotaxanes, respectively. Obtained chiral rotaxanes were revealed to have considerable enantioselectivity.
Water End Use Disaggregation Based on Soft Computing Techniques
Authors: Pastor-Jabaloyes L. , Arregui F. , Cobacho R.
Published: January 2018

Disaggregating residential water end use events through the available commercial tools needs a great investment in time to manually process smart metering data. Therefore, it is extremely difficult to achieve a homogenous and sufficiently large corpus of classified single-use events capable of accurately describe residential water consumption. The main goal of the present paper is to develop an automatic tool that facilitates the disaggregation of the individual water consumptions events from the raw flow trace. The proposed disaggregation methodology is conducted through two actions that are iteratively performed: first, the use of an advanced two-step filter, whose calibration is automatically conducted by the Elitist Non-Dominated Sorting Genetic Algorithm NSGA-II; and second, a cropping algorithm based on the filtered water consumption flow traces. As a secondary goal, yet complementary to the main one, a semiautomatic massive classification process has been developed, so that the resulting single-use events can be easily categorized in the different water end uses in a household. This methodology was tested using water consumption data from two different case studies. The characteristics of the households taken as reference and their occupants were unequivocally dissimilar from each other. In addition, the monitoring equipment used to obtain the consumption flow traces had completely different technical specifications. The results obtained from the processing of the two studies show that the automatic disaggregation is both robust and accurate, and produces significant time saving compared to the standard manual analysis.
Ovarian Function after Chemotherapy in Young Breast Cancer Survivors
Authors: Morarji K. , McArdle O. , Hui K. , Gingras-Hill G. , Ahmed S. , Greenblatt E. M. , Warner E. , Sridhar S. , Ali A. M. F. , Azad A. , Hodgson D. C.
Published: January 2018

Background: As cure rates for breast cancer improve, there is increasing evidence that late effects of treatment—and impaired fertility in particular—are emerging as important concerns among young breast cancer survivors. Older reports have evaluated the occurrence of amenorrhea after treatment, but few data have been reported about the incidence of biochemical evidence for impaired ovarian function in patients who do not become overtly menopausal. Methods: We conducted a cross-sectional study evaluating anti-Müllerian hormone (AMH) in premenopausal chemotherapy-treated breast cancer survivors and control patients. Random serum levels of AMH and other relevant clinical data were collected for 100 premenopausal chemotherapy-treated breast cancer survivors and 76 control subjects. Subgroup analyses were performed for women with regular menstrual cycles at the time of AMH testing. Results: After adjustment for age, AMH was significantly lower in the overall group of patients receiving chemotherapy (p = 0.002) and in the subgroup reporting normal cycles (p = 0.03). Cyclophosphamide produced a significant dose-dependent reduction in AMH (p < 0.001); trastuzumab was associated with increased AMH in survivors with normal cycles. Overall, serum AMH in survivors was roughly equivalent to that measured in control patients 12 years older. Conclusions: Young breast cancer survivors often experience significant impairment of ovarian function despite having normal menstrual cycles after treatment. Those results have important implications for patient counselling and the timing of possible referral to a fertility specialist.