The Effect of Discontinuing Continuous Glucose Monitoring in Adults With Type 2 Diabetes Treated With Basal Insulin
Authors: Aleppo Grazia , Beck Roy W. , Bailey Ryan , Ruedy Katrina J. , Calhoun Peter , Peters Anne L. , Pop-Busui Rodica , Philis-Tsimikas Athena , Bao Shichun , Umpierrez Guillermo , Davis Georgia , Kruger Davida , Bhargava Anuj , Young Laura , Buse John B. , McGill Janet B. , Martens Thomas , Nguyen Quang T. , Orozco Ian , Biggs William , Lucas K. Jean , Polonsky William H. , Price David , Bergenstal Richard M. ,   MOBILE Study Group, Martens Thomas , Carlson Anders , Bergenstal Richard M. , Chambers Sharon , Yang Shoua , Young Laura , Buse John , Kirkman M. Sue , Kass Alexander , Fraser Rachael , Kruger Davida , Cushman Terra , Davis Georgia , Ramos Clementina , Umpierrez Guillermo , Peters Anne L. , Magar Maria , Walker Martha , Serafin-Dokhan Sara , McGill Janet B. , Salam Maamoun , Hurst Stacy , Clifton Mary Jane , Aleppo Grazia , Kravarusic Jelena , Bansal Anupam , Fulkerson Candice , Pop-Busui Rodica , Ang Lynn , Richardson Caroline , Mizokami-Stout Kara , Reiss Jake , Leone Virginia , Bhargava Anuj , Stifel Kirstie , Philis-Tsimikas Athena , Dailey George , Change Amy , McCallum James , Garcia Maria Isabel , Bao Shichun , Davis Dianne , Lovell Cynthia , Root Connie , Biggs William , Toler Freida , Wilhelm Lori , Eifert Robin , Murguia Lorena , Cota Becky , Nguyen Quang T. , Nguyen Loida , Lipski Randie , Orozco Ian , Lawrence Mary Katherine , Fournier Adelle , Carter Matthew , Lucas K. Jean , Hoover Stephanie , Beck Roy W. , Ruedy Katrina J. , Calhoun Peter , Bailey Ryan , Cohen Nathan , Mouse Thomas , Rusnak Jessica , Campos Tiffany , Price David , Njeru Nelly , Arant Tom , Beck Stayce E. , Balo Andrew 
Published: September 2021

OBJECTIVE

To explore the effect of discontinuing continuous glucose monitoring (CGM) after 8 months of CGM use in adults with type 2 diabetes treated with basal without bolus insulin.

RESEARCH DESIGN AND METHODS

This multicenter trial had an initial randomization to either real-time CGM or blood glucose monitoring (BGM) for 8 months followed by 6 months in which the BGM group continued to use BGM (n = 57) and the CGM group was randomly reassigned either to continue CGM (n = 53) or discontinue CGM with resumption of BGM for glucose monitoring (n = 53).

RESULTS

In the group that discontinued CGM, mean time in range (TIR) 70–180 mg/dL, which improved from 38% before initiating CGM to 62% after 8 months of CGM, decreased after discontinuing CGM to 50% at 14 months (mean change from 8 to 14 months −12% [95% CI −21% to −3%], P = 0.01). In the group that continued CGM use, little change was found in TIR from 8 to 14 months (baseline 44%, 8 months 56%, 14 months 57%, mean change from 8 to 14 months 1% [95% CI −11% to 12%], P = 0.89). Comparing the two groups at 14 months, the adjusted treatment group difference in mean TIR was −6% (95% CI −16% to 4%, P = 0.20).

CONCLUSIONS

In adults with type 2 diabetes treated with basal insulin who had been using real-time CGM for 8 months, discontinuing CGM resulted in a loss of about one-half of the initial gain in TIR that had been achieved during CGM use.