bluuebunny/crossref_metadata_2025 huggingface dataset:
Agrochemical aspects of the rehabilitation of radioactively contaminated flood meadows of the Bryansk region
Authors:   Bryansk State Agrarian University, Chesalin S.F. , Smolsky E.V. ,   Bryansk State Agrarian University
Published: December 2022

Natural fodder lands are a fodder base for livestock production in Bryansk region. The lands cover the area of 5500 km2, its greater part was contaminated with long-lived artificial radionuclides due to the Chernobyl accident. Therefore, there was a risk of contamination of the forage for dairy livestock with Cs-137 and its content in the grass would exceed the acceptable limit. Long after the Chernobyl accident the measures to remediate contaminated floodplains in Iput River in Novozybkovsky district of the Bryansk region for further use in feed production were examined. It was found that if Cs-137 contamination density exceeded 555 kBq/m2 the radionuclide content in the mass of air-dry wild grasses would be ≥5.5 times higher than the acceptable limit depending on a harvesting period. Due to the use of agrotechnical and organizational measures to improve the quality of radiation contaminated flood meadows the Cs-137 specific activity in air-dry cultivated grasses reduced by 10% as compared with the radionuclide activity in natural/wild grasses. The use of agrochemical measures for remediation of radiation contaminated flood meadows allowed to obtain air-dry masses of wild and cultivated grasses with the acceptable limit of Cs-137 radioactivity in fodders. The maximum effect was obtained when applying mineral fertilizers with a ratio of nitrogen to potassium as 1:2. Due to the use of correlation analysis it became made evident that the presence of nitrogen fertilizer increased Cs-137 specific activity in the fodder and there was the correlation between calendar years of the study and the amount of nitrogen fertilizers in soil. The correlation between the amount of nitrogen fertilizer in the soil and the specific activity of Cs-137 in the air-dry mass of natural and cultivated grasses during the years of 2003-2008 was strong and ranged from 0.76 to 0.85. In the study periods from 2009 to 2014, the impact of nitrogen fertilizer on the radionuclide specific activity in feed decreased regardless of the harvest period of natural and cultivated grasses. The correlation coefficient ranged from 0.38 to 0.58, the correlation strength was average. With the use of correlation analysis nitrogen fertilizers were found to increase the specific activity of Cs-137 in airdry grass mass, the correlation strength depends on calendar years of the study, it may be strong and average. Adding potassium fertilizer into soil negate the negative effect of nitrogen fertilizers. The use of radioactive floodplains as hay fields without the use of agrochemical measures is unacceptable. According to made calculations, the use of coarse fodder grown on radiation contaminated lands leads to milk contaminated with Cs-137 content that exceeds the limit established by standard.
Предельно короткие импульсы в оптически анизотропной среде, содержащей углеродные нанотрубки с металлической проводимостью
Authors: Дадашян Л.Х. , Трофимов Р.Р. , Конобеева Н.Н. , Белоненко М.Б.
Published: December 2022

In this work, we study the interaction of extremely short pulses with a nonlinear anisotropic optical medium with carbon nanotubes (armchair and zigzag type) with metallic conductivity. The dependence of the pulse shape, width, and intensity on the nanotube chirality indices is analyzed. The most appropriate type of carbon nanotubes is substantiated for providing localized propagation of an electromagnetic field in a medium with anisotropic properties.
Application of Virtual and Augmented Reality Technology in Hip Surgery: Systematic Review
Authors: Sun Peng , Zhao Yao , Men Jie , Ma Zhe-Ru , Jiang Hao-Zhuo , Liu Cheng-Yan , Feng Wei
Published: December 2022

Background

Virtual and augmented reality (VAR) represents a combination of current state-of-the-art computer and imaging technologies and has the potential to be a revolutionary technology in many surgical fields. An increasing number of investigators have developed and applied VAR in hip-related surgery with the aim of using this technology to reduce hip surgery–related complications, improve surgical success rates, and reduce surgical risks. These technologies are beginning to be widely used in hip-related preoperative operation simulation and training, intraoperative navigation tools in the operating room, and postoperative rehabilitation.

Objective

With the aim of reviewing the current status of virtual reality (VR) and augmented reality (AR) in hip-related surgery and summarizing its benefits, we discussed and briefly described the applicability, advantages, limitations, and future perspectives of VR and AR techniques in hip-related surgery, such as preoperative operation simulation and training; explored the possible future applications of AR in the operating room; and discussed the bright prospects of VR and AR technologies in postoperative rehabilitation after hip surgery.

Methods

We searched the PubMed and Web of Science databases using the following key search terms: (“virtual reality” OR “augmented reality”) AND (“pelvis” OR “hip”). The literature on basic and clinical research related to the aforementioned key search terms, that is, studies evaluating the key factors, challenges, or problems of using of VAR technology in hip-related surgery, was collected.

Results

A total of 40 studies and reports were included and classified into the following categories: total hip arthroplasty, hip resurfacing, femoral neck fracture, pelvic fracture, acetabular fracture, tumor, arthroscopy, and postoperative rehabilitation. Quality assessment could be performed in 30 studies. Among the clinical studies, there were 16 case series with an average score of 89 out of 100 points (89%) and 1 case report that scored 81 (SD 10.11) out of 100 points (81%) according to the Joanna Briggs Institute Critical Appraisal Checklist. Two cadaveric studies scored 85 of 100 points (85%) and 92 of 100 points (92%) according to the Quality Appraisal for Cadaveric Studies scale.

Conclusions

VR and AR technologies hold great promise for hip-related surgeries, especially for preoperative operation simulation and training, feasibility applications in the operating room, and postoperative rehabilitation, and have the potential to assist orthopedic surgeons in operating more accurately and safely. More comparative studies are necessary, including studies focusing on clinical outcomes and cost-effectiveness.
Nursing Students’ Experience of Metaverse-based Career Mentoring: A Mixed Methods Study (Preprint)
Authors: Kim Yujeong , Kim Mi Young
Published: December 2022

BACKGROUND

There is a lack of studies on metaverse-based career mentoring for college students in both the quantitative and qualitative research.

OBJECTIVE

This study aimed to examine the effect of metaverse-based career mentoring among nursing students and explore the experiences of mentors and mentees.

METHODS

To test the effect of metaverse-based career mentoring, this study used a 1 group pretest–posttest and mixed-method design, in which focus group interviews were conducted regarding the participants’ experiences. A total of 8 mentors and 43 mentees participated in the metaverse-based career mentoring program, and 7 mentors and 12 mentees participated in the focus group interviews. The program covered 8 career fields and was delivered across 8 sessions of 60 minutes each, over 6 days. Platform and program satisfaction surveys were conducted among mentors and mentees, and career decision-making self-efficacy was measured before and after the program. We analyzed the quantitative data using descriptive statistics, paired t-test, Wilcoxon signed-rank test, and Mann-Whitney U test. The qualitative data underwent thematic analysis.

RESULTS

After the metaverse-based career mentoring program, mentees’ career decision-making self-efficacy increased significantly compared to the baseline level. From the mentor and mentee focus group interviews, 3 key themes were derived: (i) communicating frankly and openly, (ii) being satisfied with realistic communication and program functions, and (iii) expecting an even more optimized program.

CONCLUSIONS

A metaverse-based career mentoring program for nursing students can have a positive effect on their career decision-making self-efficacy.
Responding to the Crisis in Emotional-behavioral and Mental Health in Children and Youth by Leveraging Automation of a Collaborative Data Platform (Preprint)
Authors: Klein Benjamin , Aditya Ishan , Seth Puneet
Published: December 2022

BACKGROUND

Emotional-behavioral and mental health (EBMH) disorders in pediatrics have been on the rise prior to the pandemic, and have escalated in response to it. Deeply rooted systemic issues, such as fragmentation of care for EBMH and lack of provider capacity, inherent complexities of EBMH, such as its focus on more time-consuming biopsychosocial analyses, along with the lack of a scalable infrastructure to meet the explosion in demand have led to extreme delays in receiving care.

OBJECTIVE

In this case study, we explore a promising approach to help tackle this problem through the use of a data-centric and collaborative clinical framework.

METHODS

This involves three key elements: 1) the development of an end-to-end clinical pathway that describes the flow of narrative and discrete dimensional data from patients with EBMH concerns through the utilization of both existing validated measures and practical clinical measures; 2) the automated collection of this data from the appropriate individuals and sources; 3) the integration of this information into a collaborative health record in a manner that accomplishes automation in documentation and administrative activity within the health record, while optimally displaying this rich data set in a clinically effective manner at point-of-care.

RESULTS

From the perspective of the clinic, the total volume of visits accomplished per year was recorded. Without any change in staffing or other significant operational changes, a 91.6% increase in number of visits was noted within 3 years of maturation of the workflow. A feedback questionnaire was also made available to the patient’s caregivers to complete on a voluntary basis in the first year of the deployment. 26 responses were obtained. There was a net positive response to the questions “The questionnaire helped me express my concerns” and “I am satisfied with these questionnaires as a way to provide information about my child to the medical team”.

CONCLUSIONS

The development and utilization of this framework over the last 3 years in an iterative fashion has yielded both remarkable results in clinical efficiency while also producing a unique and comprehensive real-time data set that can be leveraged for intelligent clinical triage and fueling of clinical-decision support algorithm development. It is felt that this approach has the ability to represent a paradigm shift in quality improvement and access to care for patients in need of support with EBMH.
Analysis of the Top-Ranking Opioid Use Disorder Videos on TikTok: Retrospective Observational Study (Preprint)
Authors: Phan Paul , Marzouk Sammer , Davis Kendrick , Monge Margarita , Goodcoff Adam , Ankem Amala , He Shuhan
Published: December 2022

BACKGROUND

Opioid use disorder is a serious medical condition becoming increasingly prevalent today, affecting over 2.1 million located in the United States and over 16 million people worldwide. The condition can be detrimental if left untreated and can gravely affect the patient’s life and those around them. Within the years, digital media has been used by many to share opinions and knowledge about health issues. OUD has not been spared from this reality. TikTok, a short video platform, has been the fastest growing application in recent years and around 1.8 billion monthly active users are expected by the end of 2022 on the Chinese application. Currently, there is a lack of research on the OUD topic on TikTok.

OBJECTIVE

The aim of this study is to explore and analyze the content and authors of the top-ranking OUD videos on the TikTok platform.

METHODS

In this retrospective observational study, TikTok videos were analyzed between July 2022 and August 2022 to evaluate the content and authors of the top ranking publicly available videos (n=509) related to opioid use disorder. Top ranking videos were chosen based on the five most common hashtags pertaining to the OUD topic on the platform, which were determined by survey analysis. Once the data was collected, videos were organized based on their content (educational, awareness, misinformation, political, humorous) and on the type of author (medical professionals, patients, relatives or friends of patients, media outlets, others). Statistical analysis used inter-rater reliability ratio.

RESULTS

Most videos analyzed were about awareness (62%) and the majority of authors were patients (51%). The minority of videos were about misinformation (0%) and the least represented authors were media outlets (2%). The IRR was 79.37% for content type and 79.57% for author type.

CONCLUSIONS

Concerning the fact that most of content type was awareness and most of authors were patients, this finding could suggest that users are trying to warn others about opioid usage, having themselves gone through this form of addiction. At the time of writing, the platform does not screen for outdated videos and there is no algorithm yet to define which is obsolete or not. There is also no way of verifying if the information posted is valid or not. Clinical judgement is therefore critical when using the platform. Additional research is needed on opioid use disorder on TikTok.
Reef Fish Species Diversity Using Environmental DNA Metabarcoding in Mansinam and Lemon Island Waters, Manokwari Regency
Authors: Pranata Bayu , Kusuma Aradea Bujana , Azhar Muhamad Ilham
Published: December 2022

Biodiversity has an essential role in the stability of an ecosystem. A high level of biodiversity indicates a more stable and stable ecosystem. The decline in the quality of ecosystems such as coral reefs, seagrass beds, and mangrove forests due to anthropogenic factors and global warming threaten biodiversity. This study aims to determine the diversity of reef fish species using an environmental DNA (eDNA) approach in the waters of the Mansinam and Lemon, Manokwari Regency islands. The analysis results detected 158 individual fish comprising 26 species from 10 families (sequence identity 97-100%). The highest species abundance was found in the Pomacentridae Family. The Pomacentridae family is an ornamental fish species in coral reef ecosystems. In addition, several species from the families Serranidae, Caesionidae, Mullidae, Holocentridae, Balistidae, Scaridae, and Labridae were also detected; fish species from these families are catch targets for fishers with economic value. Assessment of fish species diversity using the Shannon-Wiener method. The diversity of fish species in the waters of the islands of Mansinam and Lemon is in the high category, namely 3.17. High diversity indicates a stable and stable ecosystem condition.
Osteocranium of the Sailfish (Istiophorus platypterus, Shaw & Nodder, 1792) from Malacca Strait
Authors: Akmal Yusrizal , Rahman Mujibul , Muliari Muliari , Batubara Agung Setia
Published: December 2022

The features and morphometrics of the sailfish's osteocranium are examined in this study (Istiophorus platypterus, Shaw & Nodder, 1792). I. platypterus has a total weight of ±20 kg with a total length of ±218 cm. The stages of the research process included preparing samples, preparing osteocraniums, documenting photos, editing images, and identifying terminology related to osteocraniums. The Laboratory of Mathematics and Natural Sciences at Almuslim University handled every aspect of the research. The osteocranium preparation process was carried out physically and chemically. Each bone was documented using a camera and edited using Adobe Photoshop CS6. The neurocranium is divided into four components: the olfactory (ethmoidal), which comprises 6 bones. The orbitale comprises 4 bones, the otic comprises 5, and the occipital comprises 4 bones. The branchiocranium is divided into five components: the oromandibular structure consisting of 3 bones, the mandibular arc (suspensorium) composed of 4 bones, the opercular apparatus consisting of 4 bones, and the hyoid arc composed of 6 bones, and the branchial arc composed of 4 bones.
Some Aspects of the Reproductive of Japanese Threadfin Bream (Nemipterus japonicus Bloch, 1791) Caught in the Area Around the Artificial Reef In the Pitu Sunggu Waters of the Makassar Strait
Authors: Kantun Wayan , Moka Wilma
Published: December 2022

Japanese Threadfin Bream is a demersal fish commonly found around artificial reefs. Food availability in the artificial reef ecosystem is essential for the sustainability of this species. Hence, this research aimed to determine several aspects of bio-reproduction of Japanese Threadfin Bream caught in the artificial reef (bioreeftek). Samples were taken using handline fishing, twice a month (April-July 2020) in Pitu Sunggu Waters, Makassar Strait. The samples were observed for its reproduction aspects.  The result showed that the Japanese Threadfin Bream fish caught have a balanced sex ratio between males and females, 1:1.03. The analysis of the gonad maturity stage obtained was II-IV, and the gonado somatic index ranged from 0.541-0.940 for males and 1.156-2.358 for females. The first mature Japanese Threadfin Bream size was 18.29 cm for males and 16.99 cm for females. The Japanese Threadfin Bream fish fecundity ranged between 35.042-42.061 eggs.
Preparation of Attapulgite Loaded Nano Zero Valent Iron Material and Its Adsorption of Silver
Authors: Bao Leilei , Shen Hanfang , Cheng Jiale , Lang Chunyan
Published: December 2022

In the extensive industrial production process, a large amount of silver containing wastewater has been produced, and the veil of its potential harm has gradually been unveiled. The emission standards of various pollutants formulated and issued by the Ministry of Ecology and Environment of China have already strictly limited the emission limits of silver. In this paper, a simple, environment-friendly and inexpensive method was used to synthesize a composite material with reducing and adsorbing effects on silver by using purified attapulgite and ferrous salt (FeSO4·7H2O) as raw materials, potassium borohydride (KBH4) as reducing agent, and chemical liquid phase reduction method. The experimental results showed that under the conditions of 1:1 ratio of iron to soil, 0.25 mol·L-1 concentration of KBH4, 25 C temperature and 120 min time, the synthesized attapulgite loaded nano-zero-valent iron composite (nZVI/ATP) had good adsorption performance for Ag(I).
A SYSTEMATIC REVIEW OF FIVE HERBAL INGREDIENTS FOR THE MANAGEMENT OF DIABETES MELLITUS
Authors: RAHUL GOPALAKRISHNAN , NANDHAKUMAR ELUMALAI
Published: December 2022

Diabetes mellitus (DM) is becoming a common metabolic disorder which has serious threatening to public health that leads to huge economic loss in the developing countries. There are some antidiabetic drugs available that helps in controlling diabetes but there is no permanent remedy which reliefs to get completely cure from this disorder. By conducting huge number of research study, numerous herbal medicines have been found for diabetes. Extracts isolated from different natural resources especially plants have always been a rich arsenal for controlling and treating diabetes and its complication. Herbs used in the preparation of the polyherbal formulation were Cassia auriculata, Gymnema sylvestre, Syzygium cumini, Trigonella foenum-graecum, and Cinnamomum zeylanicum. Phytochemical qualitative analysis indicated the presence of flavonoids, alkaloids, terpenoids, tannins, steroids, carbohydrates and glycosides. So this review helps to understand the importance of five herbal ingredients present traditionally which can be used to treat DM.
COMPARISON OF DEXMEDETOMIDINE AND LIGNOCAINE ON ATTENUATION OF PRESSOR RESPONSES DURING TRACHEAL EXTUBATION
Authors: PRAJAPATI JAYSHRI , PATEL MAITRI
Published: December 2022

Objectives: The aim of the study was to evaluate and observe the effects of single bolus intravenous dose of Dexmedetomidine with Lignocaine on the hemodynamic changes and pressor responses during tracheal extubation in patients undergoing elective surgery under general anesthesia.
Methods: This prospective and observational study was conducted in anesthesia department of tertiary care teaching hospital of Gujarat. Group A received single bolus dose of Dexmedetomidine 0.5μg/kg IV (diluted in 10 ml normal saline) over 10 min after completion of surgery and Group B received single bolus dose of Lignocaine 1.5 mg/kg IV (diluted in 10ml normal saline) over 60 s before extubation. Hemodynamic parameters were recorded before administration of drug (baseline), at extubation and post-extubation in both groups. Extubation quality was evaluated using a five-point scale. Complications were also compared in both the groups.
Results: Heart rate was 89.67±7.19 beats/minute in Group A at the time of extubation and in Group B, it was 115±6.88 beats/min which was found highly significant (p<0.0001). Mean systolic blood pressure (SBP) in Group A was 130.55±9.4 mmHg at the time of extubation and in Group B, it was 142±9.58 mmHg which was highly significant (p<0.0001). Mean diastolic blood pressure (DBP) in Group A was 85.76±3.26 mmHg at the time of extubation and in Group B, it was 99.1±2.86 mmHg which was highly significant (p<0.0001). Statistical significant difference was also observed between both the groups for heart rate, SBP, and DBP from extubation to 60 min post-extubation (p<0.05).
Conclusions: This study concluded that single bolus dose of intravenous Dexmedetomidine was more effective in maintaining hemodynamic stability and attenuating airway reflex responses as compared to lignocaine.
BREASTFEEDING PRACTICES IN RURAL FIELD PRACTICE AREA OF A GOVERNMENT MEDICAL COLLEGE IN NORTHERN INDIA
Authors: NAZIR FOZIA , TALI SHOWKAT HUSSAIN , SHORA TAJALI , YOUSUF SHAGUFTA
Published: December 2022

Objective: The objective of this study was to assess the exclusive breastfeeding practices among the lactating mothers in rural field practice areas of a Government Medical College Anantnag.
Methods: It was a community-based cross-sectional study conducted in rural field practice area, Department of Community Medicine GMC Anantnag, for 6 months from May 2021 to October 2021. A total of 120 lactating mothers were interviewed who had delivered 1 year back. The study participants were selected by systematic sampling method.
Results: In this study, 120 lactating mothers were interviewed. Around 68.4% of the mothers were in the age group of 20–30 years, 60% were illiterate, 78% of the mothers belonged to joint families, and 93.3% had institutional deliveries. The practice of exclusive breastfeeding among lactating mothers was 71.6%. Colostrum and pre-lacteal feeds were given by 93.4% and 80.8% of the mothers, respectively.
Conclusion: The present study shows that the prevalence of breastfeeding is higher in the rural population. It is clear that delayed initiation of breastfeeding and use of pre-lacteal feeds is prevalent among mothers. There was also lack of knowledge of proper breastfeeding practices among rural women.
FROZEN SHOULDER: DOES HYDRODILATATION WITH STEROID HAS ADDED ADVANTAGE OVER INTRA-ARTICULAR STEROID INJECTION
Authors: CHOUDHARY NITIN , GUPTA SANJEEV
Published: December 2022

Objective: In our study, we will compare the efficacy of intra-articular steroid injection with hydrodilatation (with steroid) with regards to Shoulder Pain and Disability Index (SPADI), visual analog scale (VAS), and range of motion (ROM) in patients of adhesive capsulitis.
Methods: The study is a prospective study carried out on 36 patients in Department of Orthopaedics, Government Medical College, Jammu, from August 2021 to July 2022. The patients were evaluated in terms of SPADI, VAS, and ROM (flexion, abduction, and external rotation) at 0-, 6-, 12-, and 24-week interval.
Results: Hydro-dilatation has better results in comparison to intra-articular steroid injection. The patients with hydrodilatation fared with better scores in terms of SPADI as well as VAS with significant p-value (≤0.05). In addition, the patients also had better ROM in the former group.
Conclusion: Hydrodilatation with corticosteroid provides better relief in terms of pain as well as ROM for frozen shoulder when compared to intra-articular CSI. The predictability of results with hydrodilatation is excellent and hence it is a better modality of treatment compared to intra-articular CSI.
INCLISIRAN (LEQVIO): A FIRST-IN-CLASS SMALL INTERFERING RNA THERAPEUTIC DRUG APPROVED BY FDA FOR TREATING PRIMARY HYPERCHOLESTEROLEMIA OR DYSLIPIDEMIA
Authors: VENUNGOPAL PRIYANKA , BALAKRISHNAN KARTHIKEYAN , SRIRAM DAMAL KANDADAI , GEORGE MELVIN
Published: December 2022

Elevated levels of low density lipoprotein (LCL) – cholesterols are an established risk factor for the development and progression of cardiovascular diseases, particularly atherosclerosis. Statins are the first-line treatment for dyslipidemia which helps in lowering lipid levels (bad cholesterol). Although statin therapy is a conventional and gold-standard method, some patients who have high cardiovascular risk are either intolerant to statins or have persistently elevated LDL levels despite receiving highest dose of statin. Therefore, for such patients, proprotein convertase subtilisin/ kexin Type 9 (PCSK9) inhibitor drugs are recommended. This review highlights the importance of PCSK9 inhibitors, focusing mainly on the recently approved (Food and Drug Administration) first-in-class small interfering RNA therapeutic drug called inclisiran (Leqvio) developed by Novartis. The article also summarizes the safety and efficacy of inclisiran based on the ORION clinical trials, benefits, and cost-effectiveness over other previously approved PCSK9 inhibitor drugs.
A COMPARATIVE STUDY TO EVALUATE MENSTRUAL HYGIENE AMONG RURAL AND URBAN ADOLESCENT GIRLS - A MIXED METHODOLOGY STUDY
Authors: KUKREJA SRISHTI , DAS SUBHASHREE , VERMA AAKASH , JAIN MAYANK
Published: December 2022

Objective: The objective of this study is to evaluate and compare menstrual hygiene management practice, sources of information, attitudes, and impact on social life due to menstruation in rural and urban adolescent girls.
Methods: A mixed methodology study was conducted in one rural and one urban school in Jhalawar district of Rajasthan. Quantitative data were collected from the girls using semi-structured, self-responding questionnaire and qualitative data were collected by focused group discussion. The quantitative data were collected and entered in MS Excel and analyzed using SPSS software version 23.
Results: In the urban area, 100% girls use sanitary napkins as absorbent while in the rural areas 90.5% use sanitary napkins while rest use new/old cloth as absorbent. In rural area, 17.5% had knowledge about menstruation before menarche compared to 57.8% in urban areas. Almost all (98.9%) girls in urban area had toilet facility at home with proper water supply while in rural areas 54% have no toilet facility. Many myths and taboos were prevalent in both rural and urban areas.
Conclusion: Free supply of sanitary napkins, access to water and toilet facility, increased awareness, and facility for disposal of sanitary napkins are important for girls to manage menstruation hygienically. Adolescents from urban area have better knowledge about menstruation and better menstrual hygiene practices than adolescents from rural area. Educational status of mother carries major impact on daughter’s menstrual hygiene practices.
CURRENT STATUS AND CHALLENGES OF HERBAL DRUG DEVELOPMENT AND REGULATORY ASPECT: A GLOBAL PERSPECTIVE
Authors: HOSSAIN CHOWDHURY MOBASWAR , GERA MEETA , ALI KAZI ASRAF
Published: December 2022

Conventional herbal medication has picked up a gigantic sum of intrigue around the world due to its viability in the treatment of extreme illnesses from the period of antiquated civilizations. Phytomedicines are considered a major health-care supplier around the globe, especially in rustic and farther ranges. A huge segment of individuals depends on or accept home-grown drugs as an essential cure for different afflictions rather than manufactured drugs. Researchers are paying much attention to herbal medicine as compared to synthetic drugs due to their severe side effects, and toxicity with less efficacy and specificity. Despite the significant increase in global interest in the investigation and development of new botanical products, only a few have been approved till now. Natural product medication development has significant technical and monetary hurdles, including a time-consuming formulation process, quality assurance, safety, therapeutic efficacy, promotion, and administrative issues. To meet these challenges, the regulatory agencies EMEA, ICH, AYUSH, DCGI, WHO, and U.S. FDA trying to bring these herbal drugs under the regulatory pipeline under the NDA approval process. Moreover, the process of drug discovery has also been revolutionized with the new advent of technologies such as the successful drug development of a novel therapeutic agent is critically relying on the process which adopts novel approaches and involves the concept of ADMET (i.e., absorption, distribution, metabolism, excretion, and toxicity) in the early stages of drug discovery along with the interaction profiles of herb-herb and herb-synthetic. In the present review, we will address the noteworthy opportunities and issues related to phyto-drug improvement in various developing and developed nations such as Europe, U.S. and India, its commercialization with regulatory guidelines, and recommended potential methods to bring them up into the mainstream of modern medical practices and healthcare.
EFFECTS OF RESISTANCE EXERCISE ON BLOOD PRESSURE IN HYPERTENSIVE PATIENTS OF CENTRAL INDIA: A PROSPECTIVE STUDY
Authors: AGARWAL SONIKA , JAIN MANILA , ARORA SUMIT , SHEIKHER CHANDER
Published: December 2022

Objectives: The objectives of this research were to see whether practicing resistance exercises alone can help to reduce the hypertension and can be considered as an adjunct to treat the hypertension.
Methods: It is a prospective, cross-sectional, and descriptive study conducted in the Department of Physiology, Malwanchal University over a period of 3 years. This study was carried out with a sample of 60 participants who were explained the procedure of experiment and informed consent was taken from all the participants included in the study.
Results: Systolic blood pressure, diastolic blood pressure, pulse pressure, and pulse rate were observed. Pre-test of resistance exercise group mean pulse rate is 79.52±4.14 beats/min (Mean±SD) reduced to 76.36±4.01 in post-test. Resistance exercise mean systolic blood pressure of pre-test 137.34±6.36 mmHg (Mean±SD) is reduced to post-test 134.65±6.35mm of Hg (Mean±SD). Pre-test of resistance exercise mean diastolic blood pressure 91.52±4.45 mmHg (Mean±SD) is reduced to post-test 88.45±4.31 mm of Hg.
Conclusion: Resistance exercise alone lowers systolic and diastolic blood pressure in prehypertensive and stage-1 hypertensive patients. Hence, resistance training is advised as a technique for managing the systemic hypertension.
Semaglutide treatment for obesity in teenagers: a plain language summary of the STEP TEENS research study
Authors: Weghuber Daniel , Boberg Klaus , Hesse Dan , Jeppesen Ole K , Sørrig Rasmus , Kelly Aaron S ,   for the STEP TEENS Investigators
Published: December 2022

What is this summary about?

This is a plain language summary of the STEP TEENS research study, which was originally published in the
New England Journal of Medicine
. As more teenagers are living with obesity than ever before, researchers are searching for new treatments. This was the first study looking at how well the medicine semaglutide works as a treatment for obesity in teenagers.

What were the results?

In this study, researchers looked at the effect of semaglutide on body mass index (BMI) and weight loss compared to a dummy medicine (placebo). A 17% decrease in BMI was reported for teenagers treated with semaglutide compared with placebo. For weight loss, an 18 kg decrease was seen when comparing semaglutide with placebo. Researchers found that there were more teenagers who had weight loss of 5%, 10%, 15%, and 20% or more in the group given semaglutide compared with the group given placebo. Improvements were also seen with semaglutide treatment for some risk factors for other diseases caused by obesity. Semaglutide was generally well tolerated by the teenagers with obesity in this study, and serious medication side effects did not happen very often.

What do the results mean?

The results from this study showed that there were no safety issues with semaglutide in teenagers with obesity, and that semaglutide can be used to help them lose weight.

Clinical Trial Registration
:
NCT04102189
(
ClinicalTrials.gov
)
IFsgp*-Closed Sets, Open Sets in Intuitionistic Fuzzy Topological Spaces
Authors: J Chandhini , N Uma
Published: December 2022

Abstract: In this paper, Intuitionistic fuzzy semi gp* - closed sets, Intuitionistic fuzzy semi gp* - open sets, and characteristics of Intuitionistic fuzzy semi gp* - closed sets are introduced. Here, we have also investigated their relations and properties with other Intuitionistic fuzzy sets
The Mediating effect of Nursing Professionalism on the Relationship between Self-efficacy and Confidence in Performing Intravenous injections in Senior Nursing Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Hanna
Published: December 2022

Objectives The purpose of this study was to identify the mediating effect of nursing professionalism on the relationship between self-efficacy and confidence in performing intravenous injection in senior nursing students. Methods Participants were 145 senior nursing students. Data were analyzed with SPSS Statistics 25.0 and the mediating effect was analyzed by using PROCESS Macro program. Results Self-efficacy directly affected nursing professionalism(β=.28, p<.001) and confidence in performing intravenous injections(β=.53, p<.001). Nursing professionalism directly affected confidence in performing intravenous injection(β=.43, p=.017). Nursing professinalism had a mediating effect between self-efficacy and confidence of performing intraveonus injections(Indirect effect=.12, 95%CI=0.11-0.20). Conclusions To improve confidence of performing intravenous injections in nursing students, it is necessary to improve their self-efficacy and nursing professionalism.
Effects of Hand-over Education Using PASS-BAR on Handover Performance Competency, Learning Self-Effectiveness, Major Commitment, and Communication Apprehension of Nursing Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yang Hee-Mo , Kim Yeon-Jung
Published: December 2022

Objectives The purpose of this study was to identify effects of hand-over education using PASS-BAR on handover performance competency, learning self-effectiveness, major commitment, and communication apprehension of nursing students. Methods The experimental group received hand-over education using PASS-BAR which consisted of lecture and 4 scenario based clinical practicum. Handover performance competency, learning self-effectiveness, major commitment, and communication apprehensione were measured before and after education. Data were analyzed using paired t-test by SPSS 25.0 program(IBM). Results The experimental group showed significant improvement in handover performance competency(t=-119.808, p<.001), learning self-effectiveness(t=-10.076, p<.001), major commitment(t=2.320, p<.05). But, communication apprehension of nursing students has not significantly different(t=1.108 p>.05). Conclusions The results indicate that hand-over education using PASS-BAR is effective in improving handover performance competency, learning self-effectiveness, major commitment by nursing students. Thus, it is suggested to be used to develop and provide various hand-over education for nursing students.
A Fundamental Study on Developing a Scales for Evaluating Teacher Education Outcomes
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Dongsim , Ha Youngja , Jung Youjin
Published: December 2022

Objectives The aim of this study was to develop a scales that will be used complementary to the application to the teacher education platform. Methods It was intended to overcome the limitations of the outcomes evaluation, which focus only on the results after the completion of education, and to use the merits of the platform that the learner's learning history was managed and continuously followed. Initial questions were developed through interviews with stakeholders and prior research. Results Using a survey, we developed a questionnaire system, 6 items for academic self-efficacy, 5 items for self-directed learning readiness, and 3 items for task expectations before education, 4 items for learning participation during education, and 4 items for learning participation, 3 items for action plan, 5 items for learning environment satisfaction, and 7 items for learning satisfaction, 4 items for learning transfer after education, which were confirmed using factor analysis. The final reliability is Cronbach's α of .92-.93. Conclusions The developed questionnaire will be used in connection with the teacher's learning activity data of learning analytics on the platform in the future.
Research Trend on the Effectiveness of Suicide Prevention Programs for Older Adults in Suicide Risk: Focused on Quality Indicators
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park AeShil
Published: December 2022

Objectives The purpose of this study is to examine the trends in the study of the effectiveness of suicide prevention programs for older adults in suicide risk and to present research directions for the development of suicide prevention programs in the future. Methods To this end, keywords such as ‘suicide’, ‘older adults’, ‘program’, ‘intervention’, ‘effect’, ‘effectiveness’ were searched in the National Assembly Library, KISS, Dbpia, and Riss and 10 studies of ‘suicide prevention programs for older adults in suicide risk’ published from 2000 to 2021 were analyzed based on the qualitative indicators of the research design proposed by Gersten et al. (2005) and the components of the suicide prevention program for suicide risk groups proposed by Park et al. (2022). Results First, the number of published articles increased in 2019, but none have been published since the breakout of the COVID-19 pandemic in 2020. Second, the method of screening suicide risk groups often used depression tests and suicidal ideation scales, and programs using media access accounted for half of the independent variables. Third, the majority of dependent variables were suicide ideation scales and depression tests. Fourth, as a result of analyzing whether or not Gersten et al. (2005) meets the quality indicators, most of the studies met the quality indicators, but the quality indicators were relatively low in the following areas: securing program content validity, operator information, measuring maintenance effect after program termination, and presentation of the qualitative analysis of program effectiveness. Finally, as a result of examining the components of suicide prevention programs, it was found that the following areas were insufficient: establishing safety plans, learning coping skills, forming therapeutic relationships, and forming a protection system. Conclusions Based on the results of the study, implications for the suicide prevention programs for older adults in suicide risk were discussed.
Exploring the current status of parental education for fathers and improvement plans in Childcare Support Center
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Suk Hee
Published: December 2022

Objectives This study investigated the operational status of parental education for fathers in the Childcare Support Center and explored the improvement of father education based on this. Methods Total 374 times data of parental education for fathers operated from 2018 to 2021 at the Childcare Support Center located in Busan, Ulsan, and Gyeongnam were collected, and analyzed. And In-depth interviews were conducted to derive an improvement plan. Results First, the father’s education at the center increased continuously for 4 years, but the education for fathers was not actively operated as it was conducted about 5.20 times annual average per center. Second, the education method by fathers and children was operated 1.6 times more than for fathers alone, and one-time education accounted for 65.8% of the total education. Third, father's education was operated the most in the morning on the weekend, and the group size consisted of small groups by 1-10 people and 11-20 people. Fourth, the contents of father's education, 64.1% of experiential activities with fathers and children took place, and the education related to parenting information gradually decreased. Fifth, the improvement plan for father's education is to be operated continuously with the consist of multiple programs in order to increase the participation rate of fathers, and appeared as customized education according to the situation of the child and father, comprehensive approach combining parenting information education and experiential type, an education plan through feedback. Conclusions Through this study, it was possible to check the current status of parental education for fathers at the Childcare Support Center, and explore improvements, and increase father’s participation by planning father education taking this into consideration, and will be able to enhance the effectiveness of education.
Effects of Virtual Simulation Education on Labour and Delivery care
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yu Yeong Ran
Published: December 2022

Objectives This study was conducted to confirm the effectiveness of an educational program using virtual simulation on labour and delivery care. Methods Virtual simulation education on labour and delivery care was carried out 10hours for 2days and data collection was from May to August 2021 a total of 40 students. This quasi-experimental study used a one group pre-post design, and data analysis was performed using the SPSS 25.0 program with descriptive statistics, paired t-test and Pearson's correlation coefficient. Results There was a statistically significant difference in problem-solving process(T=-2.048, p=.044), confidence of clinical practice(T=-5.306, p<.001), inquisitiveness among sub-domains of critical thinking disposition(T=-2.079), p=.041). Critical thinking disposition had positive correlation with the problem-solving process(r=.879, p<.001) and confidence of clinical practice(r=.684, p<.001). The problem-solving process had positive correlation with confidence of clinical practice(r=.750, p<.001). Conclusions The virtual simulation education program on labour and delivery care can have a positive effect on learners' critical thinking disposition, problem-solving process, and confidence of clinical practice, and provides the basis for the development of various virtual simulation education programs.
The needs analysis on adult competencies for the elderly in Korea
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Chang Eunha , Cho Daeyeon
Published: December 2022

Objectives This study aims to examine the discrepancy level of the elderly competencies and to assess the educational needs in order to enhance essential competencies for the elderly in Korea. Methods Data were collected from 315 adults with age range of 60 to 69 through online survey questionnaire on 19 adult competencies developed in the prior research. First, gap analysis was carried out to identify discrepancy between perceived importance of each competence and the current level of attainment of each competence using t-test and Borich needs assessment formula. Then, the Locus for Focus model was utilized to rank the competences, thus to determine the highest priority of the competences. Results As a result of the analysis, two competencies, which include health-management competence and finance-management competence, were identified as the highest-priority competencies for the Korean elderly to develop. The study also found that the elderly males and females showed different levels of educational needs on each competence; for example, the level of educational needs on health-management competence and digital-utilization competence were higher for the elderly males than the elderly females while no particular competence was identified as the highest-priority competence for the elderly females. In addition, different educational needs on 19 adults competencies were also shown between the employed and the unemployed. Conclusions The suggestions and practical implications of the study for developing policies and educational programs for the elderly in Korea are as follows. First, competency diagnostic system needs to be established for the Korean elderly to develop the highest-priority competencies identified in this study. Second, a variety of teaching methods can be utilized for developing digital-utilization competence of senior adults. Lastly, financial and administrative support at the institutional and local governmental level is suggested for enhancing art & cultural competence among the elderly in Korea.
The Relationships between Perceived Caring Climate and Teachers Feedback on High School Students’ Self-handicapping and Class Satisfaction in Physical Education Class
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Nam In Soo
Published: December 2022

Objectives The purposes of this study were to investigate the relationships between perceived caring climate and teachers feedback on high school students’ self-handicapping and class satisfaction in physical education class. Methods The subjects of this study consisted of 323 (boys 154, girls 169) high school students. The data was collected by quota sampling method. The used instrument of this study were the Lee(2020) for measuring caring climate scales, the Ryu(2009) for teacher feedback scale, the Hwang & Park(2010) for measuring self-handicapping scale, and the Lee & Kim(2011) for measuring class satisfaction scale. The data were analyzed by descriptive statistics, frequency analysis, factor analysis, correlation analysis, and a structural equation model as a statical method. Results The results of this study was as follows. First, caring climate negatively influenced to self-handicapping but, both praise feedback and negatively non-verbal feedback positively influenced to self-handicapping. Second, caring climate, performance knowledge/feedback/positive no-verbal feedback, praise feedback and negatively non-verbal feedback positively influenced to class satisfaction. Third, self-handicapping negatively influenced to class satisfaction. Forth, there was a mediating effect between caring climate, teachers’ feedback(praise feedback and negatively non-verbal feedback) and class satisfaction as a parameter of the self-handicapping. Conclusions The purposes of this study it was confirmed that both caring climate and teachers’ feedback had a mediating effect on class satisfaction through the self-handicapping.