bluuebunny/crossref_metadata_2025 huggingface dataset:
Gold-Based Coronands as Hosts for M3+ Metal Ions: Ring Size Matters
Authors: Sucena Suelen Ferreira , Demirer Türkan Ilgin , Baitullina Anna , Hagenbach Adelheid , Grewe Jacqueline , Spreckelmeyer Sarah , März Juliane , Barkleit Astrid , Maia Pedro Ivo da Silva , Nguyen Hung Huy , Abram Ulrich
Published: July 2023

The controlled, self-assembled synthesis of multinuclear coordination compounds can be performed via different approaches. Frequently, steric, geometric and/or electronic factors located at the ligand systems predefine the way in which metal ions can assemble them to large aggregates. For the compounds in the present paper, also the Pearson’s acidities and preferred coordination geometries of the metal ions were used as organization principles. The ligand under study, 2,6-dipicolinoylbis(N,N-diethylthiourea), H2L1ethyl, possesses ‘soft’ sulfur and ‘hard’ nitrogen and oxygen donors. One-pot reactions of this compound with [AuCl(tht)] (tht = tetrahydrothiophene) and M3+ salts (M = Sc, Y, La, Ln, Ga, In) give products with gold-based {Au3(L1ethyl)3}3+ or {Au2(L1ethyl)2}2+ coronands, which host central M3+ ions. The formation of such units is templated by the M3+ ions and the individual size of the coronand rings is dependent on the ionic radii of the central ions in a way that small ions such as Ga3+ form a [Ga⊂{Au2(L1ethyl)2}]+ assembly, while larger ions (starting from Sc3+/In3+) establish neutral [M⊂{Au3(L1ethyl)3}] units with nine-coordinate central ions.
Effective Synthesis of 4-Quinolones by Reductive Cyclization of 2′-Nitrochalcones Using Formic Acid as a CO Surrogate
Authors: Ferretti Francesco , Fouad Manar Ahmed , Abbo Cecilia , Ragaini Fabio
Published: July 2023

4-Quinolones are the structural elements of many pharmaceutically active compounds. Although several approaches are known for their synthesis, the introduction of an aryl ring in position 2 is problematic with most of them. The reductive cyclization of o-nitrochalcones by pressurized CO, catalyzed by ruthenium or palladium complexes, has been previously reported to be a viable synthetic strategy for this aim, but the need for pressurized CO lines and autoclaves has prevented its widespread use. In this paper, we describe the use of the formic acid/acetic anhydride mixture as a CO surrogate, which allows us to perform the reaction in a cheap and commercially available thick-walled glass tube without adding any gaseous reagent. The obtained yields are often high and compare favorably with those previously reported by the use of pressurized CO. The procedure was applied to a three-step synthesis from commercially available and cheap reagents of the alkaloid Graveoline.
Development and Characterization of Pickering Emulsion Stabilized by Walnut Protein Isolate Nanoparticles
Authors: Liu Jiongna , Zhang Hengxuan , Sun Xue , Fan Fangyu
Published: July 2023

This study was conducted to prepare walnut protein isolate nanoparticles (nano-WalPI) by pH-cycling, combined with the ultrasound method, to investigate the impact of various nano-WalPI concentrations (0.5~2.5%) and oil volume fractions (20~70%) on the stability of Pickering emulsion, and to improve the comprehensive utilization of walnut residue. The nano-WalPI was uniform in size (average size of 108 nm) with good emulsification properties (emulsifying activity index and stability index of 32.79 m2/g and 1423.94 min, respectively), and it could form a stable O/W-type Pickering emulsion. When the nano-WalPI concentration was 2.0% and the oil volume fraction was 60%, the best stability of Pickering emulsions was achieved with an average size of 3.33 μm, and an elastic weak gel network structure with good thermal stability and storage stability was formed. In addition, the emulsion creaming index value of the Pickering emulsion was 4.67% after 15 days of storage. This study provides unique ideas and a practical framework for the development and application of stabilizers for food-grade Pickering emulsions.
Heat Capacities of N-Acetyl Amides of Glycine, L-Alanine, L-Valine, L-Isoleucine, and L-Leucine
Authors: Štejfa Vojtěch , Pokorný Václav , Lieberzeitová Eliška , Havlín Jakub , Fulem Michal , Růžička Květoslav
Published: July 2023

As a follow-up to our effort to establish reliable thermodynamic data for amino acids, the heat capacity and phase behavior are reported for N-acetyl glycine amide (CAS RN: 2620-63-5), N-acetyl-L-alanine amide (CAS RN: 15962-47-7), N-acetyl-L-valine amide (CAS RN: 37933-88-3), N-acetyl-L-isoleucine amide (CAS RN: 56711-06-9), and N-acetyl-L-leucine amide (CAS RN: 28529-34-2). Prior to heat capacity measurement, thermogravimetric analysis and X-ray powder diffraction were performed to determine decomposition temperatures and initial crystal structures, respectively. The crystal heat capacities of the five N-acetyl amino acid amides were measured by Tian–Calvet calorimetry in the temperature interval (266–350 K), by power compensation DSC in the temperature interval (216–471 K), and by relaxation (heat-pulse) calorimetry in the temperature interval (2–268 K). As a result, reference heat capacities and thermodynamic functions for the crystalline phase from 0 K up to 470 K were developed.
A New Perspective on SPME and SPME Arrow: Formaldehyde Determination by On-Sample Derivatization Coupled with Multiple and Cooling-Assisted Extractions
Authors: Dugheri Stefano , Cappelli Giovanni , Fanfani Niccolò , Ceccarelli Jacopo , Marrubini Giorgio , Squillaci Donato , Traversini Veronica , Gori Riccardo , Mucci Nicola , Arcangeli Giulio
Published: July 2023

Formaldehyde (FA) is a toxic compound and a human carcinogen. Regulating FA-releasing substances in commercial goods is a growing and interesting topic: worldwide production sectors, like food industries, textiles, wood manufacture, and cosmetics, are involved. Thus, there is a need for sensitive, economical, and specific FA monitoring tools. Solid-phase microextraction (SPME), with O-(2,3,4,5,6-pentafluorobenzyl)-hydroxylamine (PFBHA) on-sample derivatization and gas chromatography, is proposed for FA monitoring of real-life samples. This study reports the use of polydimethylsiloxane (PDMS) as a sorbent phase combined with innovative commercial methods, such as multiple SPME (MSPME) and cooling-assisted SPME, for FA determination. Critical steps, such as extraction and sampling, were evaluated in method development. The derivatization was performed at 60 °C for 30 min, followed by 15 min sampling at 10 °C, in three cycles (SPME Arrow) or six cycles (SPME). The sensitivity was satisfactory for the method’s purposes (LOD-LOQ at 11-36 ng L−1, and 8-26 ng L−1, for SPME and SPME Arrow, respectively). The method’s linearity ranges from the lower LOQ at trace level (ng L−1) to the upper LOQ at 40 mg L−1. The precision range was 5.7–10.2% and 4.8–9.6% and the accuracy was 97.4% and 96.3% for SPME and SPME Arrow, respectively. The cooling MSPME set-up applied to real commercial goods provided results of quality comparable to previously published data.
The Enhanced Durability of AgCu Nanoparticle Coatings for Antibacterial Nonwoven Air Conditioner Filters
Authors: Zhou Fang , Peng Jiabing , Tao Yujie , Yang Longlai , Yang Dequan , Sacher Edward
Published: July 2023

Antibacterial nonwoven fabrics, incorporated with Ag, have been applied as masks and air conditioner filters to prevent the spread of disease from airborne respiratory pathogens. In this work, we present a comparison study of Ag ions: Ag and AgCu nanoparticles (NPs) coated onto nonwoven fabrics intended for use as air conditioner antibacterial filters. We illustrate their color changes and durability running in air conditioners using antibacterial activity testing and X-ray Photoelectron Spectroscopic (XPS) analysis. We found that AgCu NPs showed the best antibacterial efficacy and durability. XPS analysis indicated that the Ag concentration, on both the AgCu and Ag- NP-coated fibers, changed little. On the contrary, the Ag concentration on Ag ion-coated fibers decreased by ~30%, and the coated NPs aggregated over time. The color change in AgCu NP-coated fabric, from yellow to white, is caused by oxide shell formation over the NPs, with nearly 46% oxidized silver. Our results, both from antibacterial evaluation and wind blowing tests, indicate that AgCu NP-coated fibers have higher durability, while Ag ion-coated fibers have little durability in such applications. The enhanced durability of the AgCu NP-coated antibacterial fabrics can be attributed to stronger NP–fiber interactions and greater ion release.
Formaldehyde Oxidation of Ce0.8Zr0.2O2 Nanocatalysts for Room Temperature: Kinetics and Effect of pH Value
Authors: Yang Zonglin , Qin Gaoyuan , Tang Ruijiu , Jia Lijuan , Wang Fang , Liu Tiancheng
Published: July 2023

Ce0.8Zr0.2O2 catalysts were prepared via the co-precipitation method under different pH conditions. The catalysts were characterized via TEM, XRD, XPS, BET, Raman, and FTIR. The oxidation performance of formaldehyde was tested. Precipitation pH affects the physicochemical properties and performance of the Ce0.8Zr0.2O2 catalyst. By controlling the precipitation pH at 10.5, the Ce0.8Zr0.2O2 catalyst with the largest specific surface area, the smallest grain size with the best formaldehyde removal rate (98.85%), abundant oxygen vacancies, and the best oxidation performance were obtained. Meanwhile, the kinetic parameters of the catalyst were experimentally investigated and the calculated activation energy was 12.6 kJ/mol and the number of reaction steps was 1.4 and 1.2.
Selective Thermal and Photocatalytic Decomposition of Aqueous Hydrazine to Produce H2 over Ag-Modified TiO2 Nanomaterial
Authors: Althabaiti Shaeel Ahmed , Khan Zaheer , Narasimharao Katabathini , Bawaked Salem Mohamed , Al-Sheheri Soad Zahir , Mokhtar Mohamed , Malik Maqsood Ahmad
Published: July 2023

An Ag-modified TiO2 nanomaterial was prepared by a one-pot synthesis method using tetra butyl titanate, silver nitrate, and sodium hydroxide in water at 473 K for 3 h. X-ray diffraction, scanning electron microscopy, and transmission electron microscopy were used to determine the structure and morphology of the synthesized Ag-modified TiO2 nanomaterial. The diffuse reflectance UV-visible and photoluminescence spectroscopy results revealed that metallic Ag nanoparticles decreased the optical band gap and photoluminescence intensity of the TiO2. In addition, the Raman peak intensity and absorbance were increased after Ag modification onto TiO2. The photocatalytic efficiency of the synthesized samples was tested for decomposition of aqueous hydrazine solution under visible light irradiation. The photocatalytic efficiency of Ag-modified TiO2 nanomaterials was higher than that of bare TiO2 and Ag metal NPs due to the synergistic effect between the Ag metal and TiO2 structures. In addition, the surface plasmon resonance (SPR) electron transfer from Ag metal particles to the conduction band of TiO2 is responsible for superior activity of TiO2-Ag catalyst. The Ag-modified TiO2 nanomaterials offered a 100% H2 selectivity within 30 min of reaction time and an apparent rate constant of 0.018 min−1 with an activation energy of 34.4 kJ/mol under visible light radiation.
Sub-THz Vibrational Dynamics in Ordered Mesoporous Silica Nanoparticles
Authors: Hernando Abad Eduardo , Bouyer Frédéric , Chaabane Laroussi , Zerrouki Alan , Margueritat Jérémie , Saviot Lucien
Published: July 2023

The vibrational dynamics in the sub-THz range of mesoporous silica nanoparticles (MSNs) having ordered cylindrical mesopores was investigated. MCM-41 and SBA-15 particles were synthesized, and their structure was determined using scanning electron microscopy (SEM), low-angle X-ray diffraction (XRD), N2 physisorption analyses, and Raman scattering. Brillouin scattering measurements are reported and enabled determining the stiffness of the silica walls (speed of sound) using finite element calculations for the ordered mesoporous structure. The relevance of this approach is discussed based on the comparison between the numerical and experimental results and previous works reported in the literature.
Electrical Characteristics of CMOS-Compatible SiOx-Based Resistive-Switching Devices
Authors: Koryazhkina Maria N. , Filatov Dmitry O. , Tikhov Stanislav V. , Belov Alexey I. , Serov Dmitry A. , Kryukov Ruslan N. , Zubkov Sergey Yu. , Vorontsov Vladislav A. , Pavlov Dmitry A. , Gryaznov Evgeny G. , Orlova Elena S. , Shchanikov Sergey A. , Mikhaylov Alexey N. , Kim Sungjun
Published: July 2023

The electrical characteristics and resistive switching properties of memristive devices have been studied in a wide temperature range. The insulator and electrode materials of these devices (silicon oxide and titanium nitride, respectively) are fully compatible with conventional complementary metal-oxide-semiconductor (CMOS) fabrication processes. Silicon oxide is also obtained through the low-temperature chemical vapor deposition method. It is revealed that the as-fabricated devices do not require electroforming but their resistance state cannot be stored before thermal treatment. After the thermal treatment, the devices exhibit bipolar-type resistive switching with synaptic behavior. The conduction mechanisms in the device stack are associated with the effect of traps in the insulator, which form filaments in the places where the electric field is concentrated. The filaments shortcut the capacitance of the stack to different degrees in the high-resistance state (HRS) and in the low-resistance state (LRS). As a result, the electron transport possesses an activation nature with relatively low values of activation energy in an HRS. On the contrary, Ohm’s law and tunneling are observed in an LRS. CMOS-compatible materials and low-temperature fabrication techniques enable the easy integration of the studied resistive-switching devices with traditional analog–digital circuits to implement new-generation hardware neuromorphic systems.
A Comparative Study of Electronic, Optical, and Thermoelectric Properties of Zn-Doped Bulk and Monolayer SnSe Using Ab Initio Calculations
Authors: Al Bouzieh Najwa , Sattar Muhammad Atif , Benkraouda Maamar , Amrane Noureddine
Published: July 2023

In this study, we explore the effects of Zn doping on the electronic, optical, and thermoelectric properties of α-SnSe in bulk and monolayer forms, employing density functional theory calculations. By varying the doping concentrations, we aim to understand the characteristics of Zn-doped SnSe in both systems. Our analysis of the electronic band structure using (PBE), (SCAN), and (HSE06) functionals reveals that all doped systems exhibit semiconductor-like behavior, making them suitable for applications in optoelectronics and photovoltaics. Notably, the conduction bands in SnSe monolayers undergo changes depending on the Zn concentration. Furthermore, the optical analysis indicates a decrease in the dielectric constant when transitioning from bulk to monolayer forms, which is advantageous for capacitor production. Moreover, heavily doped SnSe monolayers hold promise for deep ultraviolet applications. Examining the thermoelectric transport properties, we observe that Zn doping enhances the electrical conductivity in bulk SnSe at temperatures below 500 K. However, the electronic thermal conductivity of monolayer samples is lower compared to bulk samples, and it decreases consistently with increasing Zn concentrations. Additionally, the Zn-doped 2D samples exhibit high Seebeck coefficients across most of the temperature ranges investigated.
Tackling (Childhood) Obesity through a Voluntary Food Reformulation Policy: A Repeated Cross-Sectional Study Investigating Nutritional Changes in the Out-of-Home Sector
Authors: Pepper Tammy , Hart Kathryn H. , Hodgkins Charo E.
Published: July 2023

The Childhood Obesity Plan aimed to reduce sugar and energy in foods through a voluntary sugar-reduction programme. Our primary objective was to determine whether this implementation strategy had been successful, focusing on the out-of-home sector. We used a repeated cross-sectional design to evaluate nutritional changes in desserts served by leading chain restaurants. We extracted nutrition information from online menus in autumn/winter 2020, for comparison with baseline (2017) and interim (2018) values extracted from third-party datasets. We assessed compliance with the 20% sugar-reduction target and category-specific energy targets by product category and for pooled desserts. Overall, sugar/portion and energy/portion decreased by 11% and 4%, respectively. Policy targets were achieved in one of five categories (ice-cream: −38% sugar, p < 0.001; −30% energy, p < 0.001). Secondary outcomes were analysed for subgroups with the necessary data. Few chains significantly reduced sugar and/or energy across their dessert range. Energy/portion was positively associated with portion weight and sugar/portion but not with sugar/100 g. More than half of adults’ desserts contained excessive sugar and/or saturated fat compared with dietary guidelines. Children’s desserts less frequently exceeded guidelines. These results demonstrate that voluntary measures can drive substantial change when technical, commercial, and operational barriers can be overcome.
Effect of Dietary Approaches on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review with Network Meta-Analysis of Randomized Trials
Authors: Jing Tiantian , Zhang Shunxing , Bai Mayangzong , Chen Zhongwan , Gao Sihan , Li Sisi , Zhang Jing
Published: July 2023

Background: Dietary patterns play a critical role in diabetes management, while the best dietary pattern for Type 2 diabetes (T2DM) patients is still unclear. The aim of this network meta-analysis was to compare the impacts of various dietary approaches on the glycemic control of T2DM patients. Methods: Relevant studies were retrieved from PubMed, Embase, Web of Knowledge, Cochrane Central Register of Controlled Trials (CENTRAL), and other additional records (1949 to 31 July 2022). Eligible RCTs were those comparing different dietary approaches against each other or a control diet in individuals with T2DM for at least 6 months. We assessed the risk of bias of included studies with the Cochrane risk of bias tool and confidence of estimates with the Grading of Recommendations Assessment, Development, and Evaluation approach for network meta-analyses. In order to determine the pooled effect of each dietary approach relative to each other, we performed a network meta-analysis (NMA) for interventions for both HbA1c and fasting glucose, which enabled us to estimate the relative intervention effects by combing both direct and indirect trial evidence. Results: Forty-two RCTs comprising 4809 patients with T2DM were included in the NMA, comparing 10 dietary approaches (low-carbohydrate, moderate-carbohydrate, ketogenic, low-fat, high-protein, Mediterranean, Vegetarian/Vegan, low glycemic index, recommended, and control diets). In total, 83.3% of the studies were at a lower risk of bias or had some concerns. Findings of the NMA revealed that the ketogenic, low-carbohydrate, and low-fat diets were significantly effective in reducing HbA1c (viz., −0.73 (−1.19, −0.28), −0.69 (−1.32, −0.06), and −1.82 (−2.93, −0.71)), while moderate-carbohydrate, low glycemic index, Mediterranean, high-protein, and low-fat diets were significantly effective in reducing fasting glucose (viz., −1.30 (−1.92, −0.67), −1.26 (−2.26, −0.27), −0.95 (−1.51, −0.38), −0.89 (−1.60, −0.18) and −0.75 (−1.24, −0.27)) compared to a control diet. The clustered ranking plot for combined outcomes indicated the ketogenic, Mediterranean, moderate-carbohydrate, and low glycemic index diets had promising effects for controlling HbA1c and fasting glucose. The univariate meta-regressions showed that the mean reductions of HbA1c and fasting glucose were only significantly related to the mean weight change of the subjects. Conclusions: For glycemic control in T2DM patients, the ketogenic diet, Mediterranean diet, moderate-carbohydrate diet, and low glycemic index diet were effective options. Although this study found the ketogenic diet superior, further high-quality and long-term studies are needed to strengthen its credibility.
Association between Depressive Symptoms and Adherence to the Mediterranean Diet in Nursing Students
Authors: Ibáñez-del Valle Vanessa , Navarro-Martínez Rut , Cauli Omar
Published: July 2023

With university admission, there are major changes in students’ daily habits that can lead to mental health problems. In this respect, adherence to a healthy diet, such as the Mediterranean diet (MD), can be very beneficial. The present study examines the associations between adherence to the MD and mental health among Spanish nursing students (n = 289). Sociodemographic data and life habits were collected electronically using a self-administered questionnaire. The participants also completed the Mediterranean Diet Adherence Screener (MEDAS-14) and the Goldberg Anxiety and Depression Scale (GADS). The percentage of anxiety and depression symptoms was high: 45.3% (n = 131) and 46.4% (n = 134), respectively. Only 35.6% reported good adherence to the MD (score ≥ 9). The statistical analysis showed poor adherence to the MD to be significantly and positively associated with depressive symptoms (p = 0.013) and the total score on the GADS (p = 0.039). A multivariable regression model analysis identified the depression subscale score as a predictor variable, with a mean risk of low adherence to the MD being 0.803 times (95%CI: 0.666–0.968, p = 0.021) among participants with greater depressive symptoms. These results support the implementation of prevention programs in universities focused on health and mental health issues.
Exploring the Microfluidic Production of Biomimetic Hybrid Nanoparticles and Their Pharmaceutical Applications
Authors: Fondaj Dafina , Arduino Ilaria , Lopedota Angela Assunta , Denora Nunzio , Iacobazzi Rosa Maria
Published: July 2023

Nanomedicines have made remarkable advances in recent years, addressing the limitations of traditional therapy and treatment methods. Due to their improved drug solubility, stability, precise delivery, and ability to target specific sites, nanoparticle-based drug delivery systems have emerged as highly promising solutions. The successful interaction of nanoparticles with biological systems, on the other hand, is dependent on their intentional surface engineering. As a result, biomimetic nanoparticles have been developed as novel drug carriers. In-depth knowledge of various biomimetic nanoparticles, their applications, and the methods used for their formulation, with emphasis on the microfluidic production technique, is provided in this review. Microfluidics has emerged as one of the most promising approaches for precise control, high reproducibility, scalability, waste reduction, and faster production times in the preparation of biomimetic nanoparticles. Significant advancements in personalized medicine can be achieved by harnessing the benefits of biomimetic nanoparticles and leveraging microfluidic technology, offering enhanced functionality and biocompatibility.
Low-Frequency Raman Spectroscopy: An Exceptional Tool for Exploring Metastability Driven States Induced by Dehydration
Authors: Guinet Yannick , Paccou Laurent , Hédoux Alain
Published: July 2023

The use of low-frequency Raman spectroscopy (LFRS; ω < 150 cm−1) is booming in the pharmaceutical industry. Specific processing of spectra is required to use the wealth of information contained in this spectral region. Spectra processing and the use of LFRS for analyzing phase transformations in molecular materials are detailed herein from investigations on the devitrification of ibuprofen. LFRS was used to analyze the dehydration mechanism of two hydrates (theophylline and caffeine) of the xanthine family. Two mechanisms of solid-state transformation in theophylline were determined depending on the relative humidity (RH) and temperature. At room temperature and 1% RH, dehydration is driven by the diffusion mechanism, while under high RH (>30%), kinetic laws are typical of nucleation and growth mechanism. By increasing the RH, various metastability driven crystalline forms were obtained mimicking successive intermediate states between hydrate form and anhydrous form achieved under high RH. In contrast, the dehydration kinetics of caffeine hydrate under various RH levels can be described by only one master curve corresponding to a nucleation mechanism. Various metastability driven states were achieved depending on the RH, which can be described as intermediate between forms I and II of anhydrous caffeine.
Nanomedicine and Hyperthermia for the Treatment of Gastrointestinal Cancer: A Systematic Review
Authors: Gago Lidia , Quiñonero Francisco , Perazzoli Gloria , Melguizo Consolación , Prados Jose , Ortiz Raul , Cabeza Laura
Published: July 2023

The incidence of gastrointestinal cancers has increased in recent years. Current treatments present numerous challenges, including drug resistance, non-specificity, and severe side effects, needing the exploration of new therapeutic strategies. One promising avenue is the use of magnetic nanoparticles, which have gained considerable interest due to their ability to generate heat in tumor regions upon the application of an external alternating magnetic field, a process known as hyperthermia. This review conducted a systematic search of in vitro and in vivo studies published in the last decade that employ hyperthermia therapy mediated by magnetic nanoparticles for treating gastrointestinal cancers. After applying various inclusion and exclusion criteria (studies in the last 10 years where hyperthermia using alternative magnetic field is applied), a total of 40 articles were analyzed. The results revealed that iron oxide is the preferred material for magnetism generation in the nanoparticles, and colorectal cancer is the most studied gastrointestinal cancer. Interestingly, novel therapies employing nanoparticles loaded with chemotherapeutic drugs in combination with magnetic hyperthermia demonstrated an excellent antitumor effect. In conclusion, hyperthermia treatments mediated by magnetic nanoparticles appear to be an effective approach for the treatment of gastrointestinal cancers, offering advantages over traditional therapies.
Pigment Epithelium-Derived Factor: Inhibition of Phosphorylation of Insulin Receptor (IR)/IR Substrate (IRS), Osteogeneration from Adipocytes, and Increased Levels Due to Doxorubicin Exposure
Authors: Jones Isobel C. , Carnagarin Revathy , Armstrong Jo , Lin Daphne P. L. , Baxter-Holland Mia , Elahy Mina , Dass Crispin R.
Published: July 2023

Objectives: Pigment epithelium-derived factor (PEDF) has been recently linked to insulin resistance and is capable of differentiating myocytes to bone. We examined in more detail the intricate signalling of the insulin pathway influenced by PEDF in skeletal myocytes. We tested whether this serpin is also capable of generating de novo bone from adipocytes in vitro and in vivo, and how the anticancer drug doxorubicin links with PEDF and cellular metabolism. Methods and key findings: We demonstrate that PEDF can inhibit phosphorylation of insulin receptor (IR) and insulin receptor substrate (IRS) in skeletal myocytes. PEDF constitutively activates p42/44 MAPK/Erk, but paradoxically does not affect mitogenic signalling. PEDF did not perturb either mitochondrial activity or proliferation in cells representing mesenchymal stem cells, cardiomyocytes, and skeletal myocytes and adipocytes. PEDF induced transdifferentiation of adipocytes to osteoblasts, promoting bone formation in cultured adipocytes in vitro and gelfoam fatpad implants in vivo. Bone formation in white adipose tissue (WAT) was better than in brown adipose tissue (BAT). The frontline anticancer drug doxorubicin increased levels of PEDF in a human breast cancer cell line, mirroring the in vivo finding where cardiac muscle tissue was stained increasingly for PEDF as the dose of doxorubicin increased in mice. PEDF also increased levels of reactive oxygen species (ROS) and glutathione (GSH) in the breast cancer cell line. Conclusions: PEDF may be used to regenerate bone from adipose tissue in cases of trauma such as fractures or bone cancers. The increased presence of PEDF in doxorubicin-treated tumour cells need further exploration, and could be useful therapeutically in future. The safety of PEDF administration in vivo was further demonstrated in this study.
A Large Area Wide Bandwidth THz Phase Shifter Plate for High Intensity Field Applications
Authors: Koral Can , Mazaheri Zahra , Andreone Antonello
Published: July 2023

We present the design, fabrication, and experimental test of a THz all-dielectric phase shifter plate. The design consists of two wave plate zones coupled in a perpendicular orientation with respect to each other. A large surface area device is realized by an additive manufacturing technique using Acrylonitrile Butadiene Styrene (ABS). Its characteristics are analytically evaluated and experimentally measured in the THz band using time domain spectroscopy and imaging routines. The proposed design enables the creation of quasi-ideal phase retardation in between the two planes with good uniformity on a large surface area. We also achieve the flexibility to select the plane of symmetry around the chosen central axes of choice with a sensitive control over the electromagnetic field polarization direction without inducing any temporal shifts in between the wave front components of the traversed beam. Due to its inherent simplicity and robustness, the phase shifter can be easily scaled at higher frequencies and potentially used in several advanced applications, including free-electron laser (FEL) systems where an accurate polarization control of high intensity beams is required.
MBD3 Regulates Male Germ Cell Division and Sperm Fertility in Arabidopsis thaliana
Authors: Shu Jia , Yin Xiaochang , Liu Yannan , Mi Yingjie , Zhang Bin , Zhang Aoyuan , Guo Hongbo , Dong Juane
Published: July 2023

DNA methylation plays important roles through the methyl-CpG-binding domain (MBD) to realize epigenetic modifications. Thirteen AtMBD proteins have been identified from the Arabidopsis thaliana genome, but the functions of some members are unclear. AtMBD3 was found to be highly expressed in pollen and seeds and it preferably binds methylated CG, CHG, and unmethylated DNA sequences. Then, two mutant alleles at the AtMBD3 locus were obtained in order to further explore its function using CRISPR/Cas9. When compared with 92.17% mature pollen production in the wild type, significantly lower percentages of 84.31% and 78.91% were observed in the mbd3-1 and mbd3-2 mutants, respectively. About 16–21% of pollen from the mbd3 mutants suffered a collapse in reproductive transmission, whereas the other pollen was found to be normal. After pollination, about 16% and 24% of mbd3-1 and mbd3-2 mutant seeds underwent early or late abortion, respectively. Among all the late abortion seeds in mbd3-2 plants, 25% of the abnormal seeds were at the globular stage, 31.25% were at the transition stage, and 43.75% were at the heart stage. A transcriptome analysis of the seeds found 950 upregulated genes and 1128 downregulated genes between wild type and mbd3-2 mutants. Some transcriptional factors involved in embryo development were selected to be expressed, and we found significant differences between wild type and mbd3 mutants, such as WOXs, CUC1, AIB4, and RGL3. Furthermore, we found a gene that is specifically expressed in pollen, named PBL6. PBL6 was found to directly interact with AtMBD3. Our results provide insights into the function of AtMBD3 in plants, especially in sperm fertility.
Bryophyte Diversity and Distribution Patterns along Elevation Gradients of the Mount Etna (Sicily), the Highest Active Volcano in Europea
Authors: Puglisi Marta , Sciandrello Saverio
Published: July 2023

Mt Etna in Sicily hosts a bryophyte floristic richness of 306 taxa, corresponding to 259 mosses, 43 liverworts, and 4 hornworts. Species richness shows a hump-shaped relationship with the elevation, with a peak at 1200–1700 m a.s.l. Chorotype patterns clearly change along an altitudinal gradient, from the Mediterranean, located at 0–300 m a.s.l., to Arctic-montane and boreo-Arctic montane at 1800–2700 m a.s.l., showing a correlation with the bioclimatic belts identified for the Mt Etna. In regard to the life form pattern, the turf species are the most represented in each elevation gradient, except at 2300–2700 m a.s.l. where the tuft species are prevalent. The life strategy pattern shows the colonists as the prevailing species, featured by an increasing trend up to 2200 m of elevation; above this limit, they are exceeded by the perennial stayers. Furthermore, taking into consideration the red-listed species (at the European and/or Italian level), as well as the species of phytogeographical interest, it was possible to identify the high bryophyte conservation priority areas; these areas are located in thermo-Mediterranean and oro-Mediterranean bioclimatic belts, the latter corresponding to the oldest substrates of the volcano where some of the most interesting bryophyte glacial relicts find refuge.
From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds
Authors: Isopencu Gabriela Olimpia , Covaliu-Mierlă Cristina-Ileana , Deleanu Iuliana-Mihaela
Published: July 2023

Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compounds as constituents for such systems. Plants, as an important source of so-called “natural products” with an enormous variety and structural diversity that still exceeds the capacity of present-day sciences to define or even discover them, have been part of medicine since ancient times. However, their benefits are just at the beginning of being fully exploited in modern dermal and transdermal delivery systems. Thus, plant-based primary compounds, with or without biological activity, contained in gums and mucilages, traditionally used as gelling and texturing agents in the food industry, are now being explored as valuable and cost-effective natural components in the biomedical field. Their biodegradability, biocompatibility, and non-toxicity compensate for local availability and compositional variations. Also, secondary metabolites, classified based on their chemical structure, are being intensively investigated for their wide pharmacological and toxicological effects. Their impact on medicine is highlighted in detail through the most recent reported studies. Innovative isolation and purification techniques, new drug delivery devices and systems, and advanced evaluation procedures are presented.
Concepts in Alpine Plant Ecology
Authors: Körner Christian
Published: July 2023

The alpine life zone is perhaps the only biome that occurs globally where mountains are high enough. At latitudinally varying elevation, the alpine belt hosts small stature plants that vary greatly in morphology, anatomy and physiology. In this contribution, I summarize a number of principles that govern life in what is often considered a cold and hostile environment. The 12 conceptual frameworks depicted include the key role of aerodynamic decoupling from free atmospheric climatic conditions, the problematic concepts of limitation and stress in an evolutionary context, and the role of developmental flexibility and functional diversity. With its topography driven habitat diversity, alpine plant diversity is buffered against environmental change, and the multitude of microclimatic gradients offers ‘experiments by nature’, the power of which awaits multidisciplinary exploration.
Sound Absorption of the Absorber Composed of a Shunt Loudspeaker and Porous Materials in Tandem
Authors: Li Xin , Cao Zhigang , Xu Lijun , Liu Bilong
Published: July 2023

To investigate the sound absorption of the absorber composed of a shunt loudspeaker (SL) and porous materials (PM) in tandem, the normal absorption coefficients for six samples of different groups of parameters are measured using impedance tubes. It is shown that a composite structure consisting of a porous material, an air layer, a shunt loudspeaker, and an air layer arranged in sequence (PM + Air1 + SL + Air2) has the potential to achieve broadband sound absorption close to three octaves in the frequency range of 200–1600 Hz. To further explore the sound absorption mechanism of “PM + Air1 + SL + Air2”, a theoretical model based on the transfer matrix method is established, and a numerical model is built in the pressure acoustic module using COMSOL Multi-physics field software. The sound absorption coefficients and acoustic impedances predicted are in good agreement with those measured. The concerned “PM + Air1 + SL + Air2” with suitable parameters has two distinguishable sound absorption peaks in the low frequency domain and a well sound absorption spectrum similar to that of the porous material layer in the high-frequency domain. The reason for the superior sound absorption performance of “PM + Air1 + SL + Air2” lies in the fact that under the common action of the diaphragm’s mechanical vibration, the circuit’s damping loss, and the porous material’s viscous dissipation, the sound energy consumption is mainly dominated by SL in the low frequency domain and captured by PM in the high-frequency domain.
Synthesis of New Monoazo Disperse Dyes for Dyeing Polyester Fabric Using Two Different Dyeing Methods: Demonstration of Their Antibacterial and Anticancer Activities
Authors: Abdelmoteleb Khaled M. A. , El-Apasery Morsy A. , Wasfy Ashraf A. F. , Ahmed Sara M.
Published: July 2023

3-(dimethylamino)-1-phenylprop-2-en-1-ones were obtained with good yields by reacting dimethylformamide dimethylacetal with different methyl ketones. 3-oxo-3-phenyl-2-(2-phenylhydrazono)propanals disperse dyes were obtained via reacting of 3-(dimethylamino)-1-phenylprop-2-en-1-ones with phenyldiazonium chloride. The novel dyes were used in dyeing polyester fabrics through two different dyeing methods at temperatures of 100 and 130 °C. We found that the color strength when using the dyeing method at 130 °C was better than the dyeing method at 100 °C. The fastness properties of dyed fabrics with these new disperse dyes were studied and gave very good results (except for fastness to light, which gave moderate results). The new dyes were evaluated against some different types of bacteria and cancer, which showed excellent and promising results for the possibility of using these dyes as antibacterial and anticancer agents.
Adaptive Neuro-Fuzzy-Based Models for Predicting the Tribological Properties of 3D-Printed PLA Green Composites Used for Biomedical Applications
Authors: Albahkali Thamer , Abdo Hany S. , Salah Omar , Fouly Ahmed
Published: July 2023

Tribological performance is a critical aspect of materials used in biomedical applications, as it can directly impact the comfort and functionality of devices for individuals with disabilities. Polylactic Acid (PLA) is a widely used 3D-printed material in this field, but its mechanical and tribological properties can be limiting. This study focuses on the development of an artificial intelligence model using ANFIS to predict the wear volume of PLA composites under various conditions. The model was built on data gathered from tribological experiments involving PLA green composites with different weight fractions of date particles. These samples were annealed for different durations to eliminate residual stresses from 3D printing and then subjected to tribological tests under varying normal loads and sliding distances. Mechanical properties and finite element models were also analyzed to better understand the tribological results and evaluate the load-carrying capacity of the PLA composites. The ANFIS model demonstrated excellent compatibility and robustness in predicting wear volume, with an average percentage error of less than 0.01% compared to experimental results. This study highlights the potential of heat-treated PLA green composites for improved tribological performance in biomedical applications.
Engineering Properties of Novel Vertical Cutoff Wall Backfills Composed of Alkali-Activated Slag, Polymer-Amended Bentonite and Sand
Authors: Jiang Zheyuan , Fu Xianlei , Shi Jianyong , Che Chi , Du Yanjun
Published: July 2023

The workability, hydraulic conductivity, and mechanical properties are essential to contaminant containment performance of cementitious backfills in vertical cutoff walls at contaminated sites. This study aims to investigate the engineering properties of a novel vertical cutoff wall backfill composed of reactive magnesia (MgO)-activated ground granulated blast furnace slag (GGBS), sodium-activated calcium bentonite amended with polyacrylamide cellulose (PAC), and clean sand (referred to as MSBS-PAC). Backfills composed of MgO-activated GGBS, sodium-activated calcium bentonite, and clean sand (referred to as MSBS) were also tested for comparison purposes. A series of tests were conducted which included slump test, flexible-wall hydraulic conductivity test, and unconfined compression test. The pore size distributions of two types of backfills were investigated via the nuclear magnetic resonance (NMR) technique. The results showed the moisture content corresponding to the target slump height was higher for MSBS-PAC backfill than that for MSBS backfill. The MSBS-PAC backfill possessed lower pH, dry density, and higher void ratio at different standard curing times as compared to MSBS backfill. The unconfined compressive strength and strain at failure of the MSBS-PAC backfill were noticeable lower than those of the MSBS backfill. In contrast, the hydraulic conductivity of MSBS-PAC backfill was approximately one order of magnitude lower than that of the MSBS backfill, which was less than 10−9 m/s after 28-day and 90-day curing. Lower hydraulic conductivity of MSBS-PAC backfill was attributed to the improvement of pore structure and pore fluid environment by PAC amendment.
Physical Simulation of Gas Injection Mechanism for High Dip Reservoir
Authors: Xiao Kang , Li Xiangling , Li Xianbing
Published: July 2023

High dip angle reservoirs are affected by gravity, resulting in poor sweep performance at the middle and high parts during waterflooding development. Previous studies have proposed top gas injection development for this type of reservoir, which has provided direction for improving the development effect of such reservoirs. However, current research efforts have mainly focused on the analysis of gas injection effects, rather than delving deeper into the gas injection mechanism and its influencing factors. Furthermore, the research methods adopted thus far have been primarily theoretical and fail to take into account the typical characteristics of high dip reservoirs in actual oilfields. Using a similarity criterion, this study establishes a high-temperature and high-pressure physical simulation device with variable inclination to analyze the impact of gas injection under various water injection conditions on the development of high dip reservoirs. The results suggest that the earlier the injection of water and gas, the slower the overall increase in water cut, and the more distinct the oil wall effect after gas injection, leading to a higher ultimate recovery. In the experiments, earlier injection timing can increase the final recovery rate by 9.59%. In addition, a visualized physical simulation device with an adjustable inclination angle has been established to analyze the sweep performance of high dip reservoirs under various gas injection timings. It is concluded that energy supplement in the early stage of pressure decline in the reservoir resulted in a more uniform movement of the oil-water interface at the bottom and the oil-gas interface at the top, and reduced the probability of water and gas channeling. The overall displacement efficiency is found to be improved with this approach. Earlier injection timing increased sweep efficiency by 5.95% and recovery efficiency by 13.2%, respectively. The injection gas source determined in this study, which is associated gas, is beneficial for low carbon plan and exhibits satisfactory oil recovery. The development of high dip reservoirs through top gas injection in combination with bottom water injection can generate a synergistic effect, which significantly enhances sweep efficiency and ultimate oil recovery. This finding provides theoretical guidance for practical implementation in the field.
Rediscovering the Textual Sources of the “De Dashizhi Pusa 得大勢志菩薩” in Cave 169 of Bingling Temple
Authors: Xiong Ye
Published: July 2023

Niche 6 in Cave 169 of Bingling Temple 炳靈寺 contains the earliest surviving Amitāyus sculpture triad in cave temples of China. This paper attempts to re-identify the textual sources of the ink inscription “De Dashizhi Pusa 得大勢志菩薩” (Skt. Mahāsthāmaprāpta Bodhisattva) from the Amitāyus sculpture triad in Cave 169. At first, it corrects the misidentification of the inscription “De Dashizhi Pusa” in recent decades. Then, it discusses the relationship between multiple scriptures and “De Dashizhi Pusa”. Considering the configuration of the niches, the theme of the sutra, the translation and transmission history of the sutra, and the content of the statue, this paper concludes that the inscription “De Dashizhi Pusa” and niche 6 should have been significantly influenced by the Lotus Sutra 法華經, although this paper does not deny the indirect and partial influence from the Pure Land texts on the Amitāyus sculpture triad during its restoration process. Such a discovery not only sheds light on the configuration of the Lotus Sutra images, but also provides art historical evidence for future exploration of the relationship between the Lotus Sutra and Pure Land Buddhism.
Skill Fusion in Hybrid Robotic Framework for Visual Object Goal Navigation
Authors: Staroverov Aleksei , Muravyev Kirill , Yakovlev Konstantin , Panov Aleksandr I.
Published: July 2023

In recent years, Embodied AI has become one of the main topics in robotics. For the agent to operate in human-centric environments, it needs the ability to explore previously unseen areas and to navigate to objects that humans want the agent to interact with. This task, which can be formulated as ObjectGoal Navigation (ObjectNav), is the main focus of this work. To solve this challenging problem, we suggest a hybrid framework consisting of both not-learnable and learnable modules and a switcher between them—SkillFusion. The former are more accurate, while the latter are more robust to sensors’ noise. To mitigate the sim-to-real gap, which often arises with learnable methods, we suggest training them in such a way that they are less environment-dependent. As a result, our method showed top results in both the Habitat simulator and during the evaluations on a real robot.
Optimizing Exoskeleton Design with Evolutionary Computation: An Intensive Survey
Authors: Stroppa Fabio , Soylemez Aleyna , Yuksel Huseyin Taner , Akbas Baris , Sarac Mine
Published: July 2023

Exoskeleton devices are designed for applications such as rehabilitation, assistance, and haptics. Due to the nature of physical human–machine interaction, designing and operating these devices is quite challenging. Optimization methods lessen the severity of these challenges and help designers develop the device they need. In this paper, we present an extensive and systematic literature search on the optimization methods used for the mechanical design of exoskeletons. We completed the search in the IEEE, ACM, and MDPI databases between 2017 and 2023 using the keywords “exoskeleton”, “design”, and “optimization”. We categorized our findings in terms of which limb (i.e., hand, wrist, arm, or leg) and application (assistive, rehabilitation, or haptic) the exoskeleton was designed for, the optimization metrics (force transmission, workspace, size, and adjustability/calibration), and the optimization method (categorized as evolutionary computation or non-evolutionary computation methods). We discuss our observations with respect to how the optimization methods have been implemented based on our findings. We conclude our paper with suggestions for future research.