bluuebunny/crossref_metadata_2025 huggingface dataset:
Drug Sensitivity Testing for Cancer Therapy, Key Areas
Authors: Lu Da-Yong , Lu Ting-Ren , Yarla Nagendra Sastry , Xu Bin
Published: August 2022

Aims:

Cancer is a high-mortality disease (9.6 million deaths in 2018 worldwide). Given
various anticancer drugs, drug selection plays a key role in patient survival in clinical trials.

Methods:

Drug Sensitivity Testing (DST), one of the leading drug selective systems, was widely
practiced for therapeutic promotion in the clinic. Notably, DSTs assist in drug selection that benefits
drug responses against cancer from 20-22% to 30-35% over the past two decades. The relationship
between drug resistance in vitro and drug treatment benefits was associated with different tumor
origins and subtypes. Medical theory and underlying DST mechanisms remain poorly understood
until now. The study of the clinical scenario, sustainability and financial support for mechanism
and technical promotions is indispensable.

Results:

Despite the great technical advance, therapeutic prediction and drug selection by DST
needs to be miniature, versatility and cost-effective in the clinic. Multi-parameters and automation
of DST should be a future trend. Advanced biomedical knowledge and clinical approaches to translating
oncologic profiles into drug selection were the main focuses of DST developments. With a
great technical stride, the clinical architecture of the DST platform was entering higher levels (drug
response testing at any stage of cancer patients and miniaturization of tumor samples).

Discuss:

The cancer biology and pharmacology for drug selection mutually benefit the clinic.
New proposals to reveal more therapeutic information and drug response prediction at genetic, molecular
and omics levels should be estimated overall.

Conclusion:

By upholding this goal of non-invasive, versatility and automation, DST could save
the life of several thousand annually worldwide. In this article, new insights into DST novelty and
development are highlighted.
Combining Network-based and Matrix Factorization to Predict Novel
Drug-target Interactions: A Case Study Using the Brazilian Natural
Chemical Database
Authors: Martins Ronald Sodre , da Costa Gomes Marcelo Ferreira , Caffarena Ernesto Raul
Published: August 2022

Background:

Chemogenomic techniques use mathematical calculations to predict new DrugTarget Interactions (DTIs) based on drugs' chemical and biological information and pharmacological
targets. Compared to other structure-based computational methods, they are faster and less expensive.
Network analysis and matrix factorization are two practical chemogenomic approaches for predicting
DTIs from many drugs and targets. However, despite the extensive literature introducing various
chemogenomic techniques and methodologies, there is no consensus for predicting interactions using a
drug or a target, a set of drugs, and a dataset of known interactions

Methods:

This study predicted novel DTIs from a limited collection of drugs using a heterogeneous ensemble based on network and matrix factorization techniques. We examined three network-based approaches and two matrix factorization-based methods on benchmark datasets. Then, we used one network approach and one matrix factorization technique on a small collection of Brazilian plant-derived
pharmaceuticals.

Results:

We have discovered two novel DTIs and compared them to the Therapeutic Target Database to
detect linked disorders, such as breast cancer, prostate cancer, and Cushing syndrome, with two drugs
(Quercetin and Luteolin) originating from Brazilian plants.

Conclusion:

The suggested approach allows assessing the performance of approaches only based on
their sensitivity, independent of their unfavorable interactions. Findings imply that integrating network
and matrix factorization results might be a helpful technique in bioinformatics investigations involving
the development of novel medicines from a limited range of drugs.
Inter-changeability Between Anterior Segment Optical Coherence Tomography and Scheimpflug Imaging in the Evaluation of Corneal Opacity
Authors: Mounir Amr , Abdellah Marwa Mahmoud , Zidan Omar Fawzy , Mostafa Engy Mohamed
Published: August 2022

Purpose

To compare the results of corneal evaluation, either the total corneal thickness and corneal opacity depth by both technologies AS- OCT and Scheimpflug imaging by Sirius Scheimpflug placido topography.

Methods

sixty-eight eyes of sixty- eight consecutive patients with corneal opacities were examined by both AS-OCT and Sirius Scheimpflug imaging. Corneal thickness and corneal opacity depth were measured and compared determining the interchangeability using Bland–Altman plotting.

Results

Total corneal thickness was (470.32±62.10) and (463.47±56.47) by AS. OCT and Sirius Scheimpflug imaging, respectively (P value = 0.8).

While the actual measurement of corneal opacity, corneal opacity depth was (135.39±119) and (85.45±128) by AS-OCT and Siris Scheimpflug imaging respectively with P value (0.004).

Conclusion

AS-OCT and Scheimpflug imaging Sirius may be used interchangeably for measuring both total corneal thickness, while in the determination of corneal opacity depth. the AS-OCT is superior to Scheimpflug imaging in the accuracy of determination of actual boundaries of the corneal opacity.
Comparing the Effect of Chamomile and Mefenamic Acid on Primary Dysmenorrhea Symptoms and Menstrual Bleeding: A Randomized Clinical Trial
Authors: Shabani Fatemeh , Narenji Fereshteh , Vakilian Katayon , Zareian Mohammad Ali , Bozorgi Mahbubeh , Bioos Soodabeh , Nejatbakhsh Fatemeh
Published: August 2022

Background:

Dysmenorrhea in young women reduces their quality of life.

Objectives:

This research reviewed the impact of chamomile sachet and mefenamic acid on primary dysmenorrhea, its relevant symptoms as well as bleeding.

Methods:

Two hundred female students afflicted with primary dysmenorrhea from Arak universities were randomly assigned to two groups and participated in this randomized clinical trial. The first group (A) received mefenamic acid (250 mg) and the second group (B) received chamomile (5000 mg) three times a day in two consecutive cycles from two days before up to the first three days after menstruation. Intensity of pain, related symptoms and bleeding were evaluated by visual analog scale, Andersch-Milsom Verbal Scale and Higham chart, respectively. Data analysis was performed by SPSS 21.

Results:

Severe pain lasting two months after intervention was observed in 6 subjects (6.3%) of group (B) as well as 6 participants (6.3%) in group (A) (p=0.351, p=0.332). Two months after treatment, mean severity of related symptoms was 4.93±3.54 in group (B) and 5.62±3.54 in group (A), which shows further reduction of pain in group (B) that was not significant (p=0.278). Two months later, mean of bleeding was 88.71±66.4 and 70.54 ±53. 34 in group (B) and (A), respectively. Thus, the decrease of pain in the two groups was not significant (p=0.567).

Conclusion:

It appears that chamomile sachet can decrease the severity of pain and bleeding, which is similar to the effect of mefenamic acid and even further alleviates the symptoms of dysmenorrhea.

(IRCT code no. 20161008250B1N5).
MCP1, CRP and Procalcitonin as Novel Diagnostic Markers in Cirrhotic Patients with Spontaneous Bacterial Peritonitis
Authors: Mohamed Amal Ahmed , Salah Wafaa , Hassan Mohamed Badr , Eldeeb Hala H. , Adaroas Ahmed Sobhy , Khattab Rania Abdelmonem , Abostate Heba M. , Soliman Moataz Yousry , Habba Eslam , Abd-Elsalam Sherief , Abo-Amer Yousry Esam-Eldin
Published: August 2022

Background & Aims:

The aim of the study was to evaluate serum c-reactive protein (CRP), ascitic procalcitonin (PCT) and monocyte chemotactic protein-1 (MCP-1) in the diagnosis of spontaneous bacterial peritonitis (SBP) in cirrhotic patients.

Methods:

A cross-sectional analytic study that included 199 patients with decompensated cirrhosis (101 with SBP and 98 without SBP). Patients were classified according to Child-Pugh criteria. Ascitic PCT and MCP-1 were measured by enzyme-linked immunosorbent assay. Serum CRP, liver and renal functions were assessed.

Results:

Three markers are significantly elevated in SBP patients than those without ascites. Using the ROC curve at AUC 0.883 and a cut-off value of >186 ng/ml, the diagnostic performance of ascitic MCP-1 level was higher than CRP (AUC 0.562) and ascitic fluid procalcitonin (AUC 0.751) in the diagnosis of SBP. The sensitivity and specificity were 86.15% and 79.59% at the cutoff of 186 ng/ml for MCP-1, 65.4 and 75.5 at ≥ 1 ng/ml for PCT, and 52.5 and 64.3, respectively for at 11.2 mg/dl CRP.

Conclusion:

Ascitic MCP-1 has a better diagnostic value with higher sensitivity and specificity in diagnosis SBP compared to CRP and procalcitonin which has higher diagnostic accuracy than CRP. Further studies with a large number will be necessary to evaluate the usefulness of these markers in diagnosis, follow-up and relation to morbidity and mortality of SBP patients.
Heavy Metal Removal with NanoTiO2/Chitosan Modified Poly(Vinylidene
Chloride)
Authors: Attia Yasser A. , Ahmed Sadeaka A. , El-Bordiny Mahmoud M. , El-Sebaay Abdellatif S. , El-Ella Amr A. , El-Din Mohamed A. Tag
Published: August 2022

Background:

Heavy metal contamination of water resources has been identified as one of the
most serious environmental issues. Chemical modification of hydrophobic polymer matrices is another
approach for changing their surface properties for water treatment. The addition of nanoparticles to polymers alters surface characteristics such as adsorption capacity, adhesion, catalytic ability, and wettability
to heavy metals in wastewater.

Objective:

Evaluation of the nanomodified polyvinyl chloride (PVC) polymer as a heavy metal adsorbent
from wastewater.

Methods:

In the field of emission discharges from industries and domestic wastes that contain unknown
inorganic pollutants by PVC using grafting chitosan/TiO2 nanocomposites. The characterization of different thin films was performed using TEM, XRD, and FTIR. The metal concentrations were measured by
using inductively coupled plasma (ICP-OES).

Results:

Nanomodification of PVC was evaluated by infrared spectroscopy. The presence of chlorine in
the PVC structure before and after the nanomodification is confirmed by the presence of a peak at 690 cm-1
attributed to the axial deformation of the C-Cl bond. The nanomodified PVC showed an ion exchange
capacity of 1.27 mmol-1
, and efficiently removed the heavy metals from aqueous solutions. The heavy
metal removal effectiveness (R) was improved by increasing the concentration of TiO2 nanoparticles. The
amount adsorbed per gram of adsorbent (Qe) was computed and revealed that the amount of adsorption
increased for nanomodified PVC thin film as compared to 100% PVC thin film. The nanomodified PVC
thin film showed high stability for 4 cycles of use. This improvement has been attributed to the nanomodified PVC polymer's large surface area (ranging from 0.3 to 282 m2
/g).

Conclusion:

The modification of PVC with nanoparticles increases the cost of PVC thin film by 15%.
However, it offers efficiency 3 times than the original PVC.
Magnetic and Dielectric Properties of 0.1 Bi2/3Cu3Ti4O12 -0.9 Bi3LaTi3O12
Nanocomposite Prepared by Semi-Wet Route
Authors: Gautam Pooja , Bharti Arvind Kumar , Tewari Anurag , Mandal Kam Deo
Published: August 2022

INTRODUCTION:

A chemical formula of nanocomposite 0.1 Bi2/3Cu3Ti4O12 -0.9 Bi3LaTi3O12 (BCLT-19) was prepared by semiwet route using metal nitrate and solid TiO2. The phase formation of Bi2/3Cu3Ti4O12 (BCT) and Bi3LaTi3O12 (BLT) was confirmed by X-ray diffraction (XRD) study.

METHOD:

Transmission electron microscope (TEM) analysis showed a nano particle of size 14 ± 5 nm on average for BCLT-19 composites. Scanning electron microscope (SEM) images exhibited a tubular, spherical and heterogeneous structure of grains. The root means square roughness, average roughness and maximum area peak height were explained by atomic force microscopy (AFM).

RESULT:

Study of magnetic properties was determined as weak antiferromagnetic to ferromagnetic and in nature. The high dielectric constant (ε' = 3147 at 100Hz to 500 K) of BCLT-19 may be due to the existence of space charge polarization.

CONCLUSION:

In this manuscript have studies on the novel composite materials of BCLT-19 micro-structural properties. This is useful for future Random-access memory devices and dielectric materials,
Industrial Aspects of Microbes
Authors: Yogesh B.J. , Bharathi S.
Published: August 2022

This chapter deals with the significance of soil microbes from an industrial
perspective. Soil microbes are the most diverse populations to exist on earth, and they
are known to have played a prominent role in the development of soil chemistry, soil
texture, and soil suitability to sustain plant life. The chapter deals with the significance
of cultural techniques for the isolation of desired microbial strains from the soil. The
importance of screening techniques for isolates is emphasized, wherein the potential
strains are tested for their physiological characteristics that are industrially beneficial.
A few criteria are mentioned for judging the soil isolate’s capability to become an
industrial strain. The difference between natural isolates and potential industrial strains
is discussed. Useful strains are categorized based on their ability to produce primary
and secondary metabolites with commercial applications in terms of economic,
agricultural, and environmental significance. Industrially important microbes are listed
with emphasis on the types of metabolites they produce and their applications.
Knowledge of metabolic pathways involved in metabolite production and their
regulation in terms of various feedback control systems are discussed. Strain
improvement and its role in improving industrial aspects of microbes are highlighted.
Bacillus sp. are given their due importance as the most diverse and dynamic forms of
bacteria, contributing immensely to our knowledge and being the most beneficial forms
of soil microbes. A few metabolites are discussed in detail, with emphasis given to
enzymes, microbial polymers, amino acids, solvents, organic acids, and antibiotics.
Microbial bioleaching mostly employs bacteria that could help in the recovery of
metals from low-grade ores, and industries based on biomining have shown a renewed
interest in this economically viable process.
Prospects of Microbes in Organic Farming under the Scenario of Climate Change
Authors: Chandra Priyanka , Sundha Parul , Rinki  , Verma Pooja , Santosh Savitha , Pandey Vanita
Published: August 2022

Climate change is one of the minacious threats that is affecting agricultural
production and food security the most. Agriculture is significantly involved in
contributing to global warming with the use of chemical fertilizers. Soil
microorganisms play an important role in several ecological processes in soil, such as
the cycling of nutrients, nitrogen fixation, nitrification/denitrification, decomposition of
organic matter, and mineralization/immobilization. These processes, carried out by
microorganisms, are one of the most important components of organic farming.
Climatic shifts are causing floods, droughts, and unseasonal rainfall and are showing
potentially devastating effects on agricultural yields. Hence, there is an urgent need to
develop strategies to make our farming systems more resilient to the consequences of
climate change. This chapter presents the synergistic advantages of organic farming
and the role of soil microbes, which could be effective climate change adaptation
strategies for the agriculture sector, and will give information on the importance of soil
microorganisms in organic farming.
Dynamic Interplay of Soil and Microbes for Sustainable Ecological Balance
Authors: A. Waoo Ashwini , Agnihotri Shivangi
Published: August 2022

A microorganism is a term given to small living beings whose size is
measured in microns. Bacteria, fungi, algae, and protozoans are a few of them that
reside in the air, water, and soil. This review is about the microorganisms found in soil.
These microorganisms have different functions in soil decomposition of dead organic
matter, such as ecological food web balance, and making nutrients available to plants.
Recently, their role in alleviating different abiotic stresses like salinity and drought has
been marvelous. These microbes are also being used in biopesticide form, which is
environmentally friendly and safe for other living organisms. Bacteria convert the
inaccessible nutrients from dead matter into usable forms. Actinomycetes give off the
typical smell of soil, and these microorganisms are also being used as a source of
therapeutic medicines. Fungi are helpful in the way that they break down impossible
nutrients, which are then available to other microbes. They also colonize plant roots
and thus aid in plant growth. Algae promote submerged aeration as their photosynthesis
is faster and adds more oxygen. Algae also help prevent the loss of nitrates that help in
building soil structures by promoting the weathering of rocks. Nematodes help
maintain the ecological equilibrium of their habitat. Viruses are the mode of gene
transfer between organisms in the soil. Thus, these microorganisms have different
functions in the soil to maintain the soil's structure and the balance between the
environment and its living beings.
An integrated fuzzy-VIKOR-DEMATEL-TOPSIS technique for assessing QoS factors of SOA
Authors:   Department of Information Technology Studies, University of Professional Studies, Accra, Ghana, et al. Aazagreyir
Published: August 2022

Quality of service (QoS) is a very important concept in service-oriented architecture (SOA). While there is a growing body of study on QoS-based service selection based on SOA, there is little research on analyzing QoS factors from the viewpoints of IT workers and researchers. As a result, the purpose of the current study aims to offer an integrated fuzzy VIKOR-TOPSIS-DEMATEL approach framework for evaluating QoS factors of online services from the viewpoint of experts in a fuzzy environment. A numerical assessment of the QoS factors for a case firm in Ghana indicated that the suggested technique is appropriate for the problem. Furthermore, the technique outcomes divided QoS factors into cause-effect variables, ranked QoS factors, and lastly, suggested conflicting QoS factors. The results from the Fuzzy DEMATEL aspect of the proposed approach found integrity, availability, accessibility, compliance, documentation, latency, and adaptability as causal variables. While response time, cost/price, reliability, performance, security, reputation, throughput, best practices, success ability, encryption, portability, storage, and consistency are regarded as influential variables. The Fuzzy TOPSIS aspect of the technique found adaptability, documentation, consistency, transaction, and accessibility are the most ranked QoS factors of online services. The fuzzy VIKOR side of the proposed method discovers integrity, cost, and latency as incommensurable QoS factors. Finally, a sensitivity analysis was carried out, and the results show the model is robust. This study confirms the position of existing knowledge on sensitivity analysis in the QoS literature. In the issue of QoS factor evaluation, this work effectively blended three MCDM techniques. The study's shortcoming stems from its reliance on data from QoS specialists from only one developing nation (i.e. Ghana).
Синтез, кристаллическая структура и высокотемпературная теплоемкость замещенных апатитов Pb-=SUB=-9-=/SUB=-R(GeO-=SUB=-4-=/SUB=-)-=SUB=-3-=/SUB=-(VO-=SUB=-4-=/SUB=-)-=SUB=-3-=/SUB=- (R=Tb, Dy, Ho)
Authors: Денисова Л.Т. , Молокеев М.С. , Голубева Е.О. , Белоусова Н.В. , Денисов В.М.
Published: August 2022

Твердофазным синтезом из исходных оксидов PbO, Tb2O3 (Dy2O3, Ho2O3), GeO2 и V2O5 последовательным отжигом (при температуре 773-1073 K) в атмосфере воздуха получены апатиты Pb9R(GeO4)3(VO4)3 (R=Tb, Dy, Ho). Методом рентгеноструктурного анализа установлена их кристаллическая структура. Высокотемпературная теплоемкость измерена методом дифференциальной сканирующей калориметрии. На основании экспериментальной зависимости теплоемкости от температуры рассчитаны термодинамические свойства. Ключевые слова: апатиты, твердофазный синтез, кристаллическая структура, теплоемкость, термодинамические свойства.
Эффект интерфейсного легирования системы наностержней оксида цинка
Authors: Рябко А.А. , Мазинг Д.С. , Бобков А.А. , Максимов А.И. , Левицкий В.С. , Лазнева Э.Ф. , Комолов А.С. , Мошников В.А. , Теруков Е.И.
Published: August 2022

The effect of an increase in the electrical conductivity of a system of zinc oxide nanorods by a factor of 10^5 during atomic layer deposition of a thin dielectric layer of aluminum oxide was found. It is shown that a change in the electrical conductivity of zinc oxide during atomic layer deposition of aluminum oxide on the surface is also observed for thin polycrystalline layers of zinc oxide. A study of polycrystalline layers of zinc oxide coated with aluminum oxide using ultraviolet and X-ray photoelectron spectroscopy is presented. Based on the results of photoelectron spectroscopy, two main factors for changing the electrical conductivity are proposed, which consist in the formation of a two-dimensional electron gas at the ZnO/Al2O3 interface and doping of the near-surface region of zinc oxide with aluminum atoms.
Термомеханика и статистическая механика адиабатически изолированного тела
Authors: Горобей Н.Н. , Лукьяненко А.С. , Гольцев А.В.
Published: August 2022

A statistical distribution for an adiabatically isolated body is proposed and its temperature is defined as a function of a given energy. It is obtained as a result of the generalization of the statistical distribution for an ensemble of oscillators, in which the probability is proportional to the time of motion on each small section of the oscillator trajectory in the phase space. This distribution makes it possible to explain the thermoelastic effect - the dependence of the body temperature on the deformation under its adiabatic mechanical loading. The proposed explanation is in clear agreement with the first law of thermodynamics. Key words: temperature, deformation, adiabatic process, internal energy, statistical distribution.
Незаполненные электронные состояния ультратонких пленок фенолфталеина на поверхности ZnO, сформированного методом молекулярного наслаивания
Authors: Комолов А.С. , Лазнева Э.Ф. , Герасимова Н.Б. , Соболев В.С. , Жижин Е.В. , Пудиков Д.А. , Содылев Р. , Пшеничнюк С.А. , Асфандиаров Н.Л. , Handke B.
Published: August 2022

The results of a study of the unoccupied electronic states of ultrathin films of phenolphthalein molecules on a ZnO surface formed by atomic layer deposition technique are presented. The atomic composition of the ZnO layer was determined by X-ray photoelectron spectroscopy (XPS) and its crystallinity was characterized using X-ray diffraction. The predominance of the content of O atoms by 5-10%, compared with the content of Zn atoms, was found. The electronic characteristics of the ZnO/phenolphthalein structure were studied using total current spectroscopy (TCS) in the energy range from 5 eV to 20 eV above EF during thermal vacuum deposition of phenolphthalein films up to 8 nm thick. Phenolphthalein molecules contain two hydroxyl functional groups. The TCS results on the phenolphthalein films are compared with the TCS results obtained from films of molecules that represent the backbone of phenolphthalein molecules without hydroxyl groups. The TCS fine structure maxima of phenolphthalein films located in the energy range from 5 eV to 8 eV above EF can be associated with the boundaries of the p* bands of electronic states. The work function of the ZnO surface formed by the ALD method were 4.2±0.1 eV. The deposition of a phenolphthalein film led to a decrease in the work function of the surface by 0.1 eV.
Antibacterial activity of ethanolic extract of Averrhoa bilimbi L. fruit against Salmonella typhi
Authors: Ni Made Riris Divayani Aristyantari  , Ni Ketut Ayu Juliasih  , Ni Luh Gede Sudaryati  , I Nyoman Arsana
Published: August 2022

Averrhoa bilimbi L. fruit has been used in Bali traditional medicine to treat typhoid fever. The fruit contains flavonoids and triterpenoids which  are considered to have antibacterial activity. This study aimed to investigate antibacterial activity of ethanolic extract of A. bilimbi L. fruit. The ethanolic extract was prepared by maceration and antibacterial activity was determined by the disc diffusion method against Salmonella typhi cultured on Mueller hinton agar (MHA). Ciprofloxacin was used as positive control and sterile distilled water as negative control. The results showed that the ethanolic extract of A. bilimbi L. fruit at various concentrations of 25; 50; 75 and 100% have an inhibition zone diameter of 0 ± 0; 13.000 ± 1.414; 18.750 ± 1.500 and 20.250 ± 1.707 mm, respectively. In addition, ciprofloxacin at concentration of 1 mg/L has an inhibition zone diameter of 34.250 ± 1.892 mm. In conclusion, the ethanolic extract of A. bilimbi L. fruit has strong antibacterial activity against S. typhi.
Liquidity Management: An Empirical Study
Authors: Das Pradip Kumar
Published: August 2022

Efficacious liquidity management is cardinal for being of an organization. Diverse components of current assets and current liabilities should be managed in such manner that an organization is able to keep appropriate liquidity structure. Adequate liquidity capacitates an organization to meet its obligations in time. Efficient liquidity management impact firm’s risk, return and share prices, and surmises its success or failure. Liquidity management is credited as a lifeline of every concern. Need for dexterous liquidity management has, thus, become prime lately. The study developed on idiolect of disparate indices reveals that the overall liquidity position of the selected company, Titan Company Ltd. is not impressive. The paper also offers few suggestions to elevate certain facets stirring healthy liquidity management.
Exploring VaKaranga cosmological ethics of kubata makuku as a panacea for conflict management and resolution in Post-colonial Zimbabwe
Authors: Muzenda Daniel
Published: August 2022

The political landscape of Zimbabwe shows that the country is battling to contain feuding conflicts in the society. It has become so obvious that any election in Zimbabwe is a contested terrain due to conflicts associated with the electoral process. Moreover, unsolved past conflicts continues to hinder the country’s socio economic stability. It is clear from the state of affair that the Church and the State have failed to resolve conflicts in Zimbabwe. The church continues to preach from its pulpit unconditional forgiveness while state continues to sweep critical issues under the carpet. It is within this context that a tap into how the VaKaranga people resolve their conflicts through the ethical theory of kubata makuku can be a panacea in conflict resolutions. Moreover, the failure by the church to take sides with the oppressed during the struggle for justice in post-colonial Zimbabwe always present a challenge to the relevance of the church.
Robert T. Conn. Bolivar’s After Life in the Americas. Biography, Ideology, and the Public Sphere. Londres: Palgrave Macmillan, 2020
Authors: Mendoza Pérez Ernesto Josué
Published: August 2022

Reseña sobre el libro de Robert T. Conn, publicado en 2020, sobre las representaciones de Bolívar durante los siglos XIX, XX y XXI en distintos países de América Latina.
Flora de Guerrero N° 1. Araliaceae (Segunda edición)
Authors:   Facultad de Ciencias, López Ferrari Ana Rosa
Published: August 2022

Se presenta la descripción taxonómica de la familia Araliaceae, con los géneros Aralia, Dendropanax y Oreopanax y 9 especies presentes en Guerrero. El género con mayor número de especies en Guerrero es Oreopanax. Se incluyen claves para identificar géneros y especies, mapas de distribución geográfica de los taxones presentes en el estado, una ilustración de una especie por cada género y una lista de ejemplares examinados en los herbarios consultados.
Paraphyletic relationships revealed by mitochondrial DNA in the Peromyscus mexicanus species group (Rodentia: Cricetidae)
Authors: Hernández-Canchola Giovani , León-Paniagua Livia , Esselstyn Jacob A.
Published: August 2022

Although deer mice (Peromyscus spp.) are among the most studied small mammals, their species diversity and phylogenetic relationships remain unclear. The lack of taxonomic clarity is mainly due to a conservative morphology and because some taxa are rare, have restricted distributions, or are poorly sampled. One taxon, P. mexicanus, includes southern Mexican subspecies that have not had their systematic placement tested with genetic data. We analyzed the phylogenetic relationships and genetic structure of P. mexicanus populations using sequences of the mitochondrial gene cytochrome b. We inferred that P. mexicanus is paraphyletic, with P. m. teapensis, P. m. tehuantepecus, andP. m. totontepecus more closely related to P. gymnotis than to P. m. mexicanus. This highly divergent clade ranges from northeastern Oaxaca to northern Chiapas, including southern Veracruz, and southern Tabasco. In light of this group’s mitochondrial distinctiveness, cohesive geographic range, and previously reported molecular, biochemical, and morphological differences, we recommend it be treated as P. totontepecus. Our findings demonstrate the need for an improved understanding of the diversity and evolutionary history of these common and abundant members of North American small mammal communities.
IMPLEMENTACIÓN DE LA DESNITRIFICACIÓN BIOLÓGICA HETEROTRÓFICA PARA REMEDIAR AGUAS SUBTERRÁNEAS PARA CONSUMO HUMANO
Authors: Dotto Cristián , Scolari Fernando , Erijman Leonardo , Figuerola Eva
Published: August 2022

La presencia de nitratos en las fuentes de agua subterránea es común en la Provincia de Buenos Aires. Puede atribuirse a labores agrícola-ganaderas o al mal diseño o funcionamiento de los sistemas sépticos. La presencia de dicho ion es perjudicial para la salud, por lo que su concentración máxima en agua potable está regulada. La desnitrificación biológica, llevada a cabo en forma ex-situ por bacterias indígenas del acuífero ha demostrado ser una forma de tratamiento conveniente para el agua de consumo humano. El objetivo del proyecto descripto consistió en establecer las condiciones locales para la configuración de una planta piloto de desnitrificación biológica de agua subterránea en la provincia de Buenos Aires. Para esto se realizaron ensayos en laboratorio en sistema batch y semicontinuo. Los resultados obtenidos permitieron el diseño y puesta en marcha de la planta piloto propuesta, la cual se encuentra en fase de prueba.
Removal of Zinc Metal from Industrial Wastewater using GCC Adsorbent
Authors: Gupta Aniket , Shukla Dr. A. K. , Patel Anand
Published: August 2022

Abstract: Nowadays, Zn-loaded wastewater released from industrial activities pose an increasing risk to human health and the environment. Adsorption processes have been widely used for the removal of zinc from the waste stream.. In this study, the efficiency of GCC adsorbent as a novel green technology in the removal of zinc from synthetic wastewater is analyzed. Batch adsorption experi- ments were conducted to evaluate the effect of contact time, pH, adsorbent dose, and initial concentration of adsorbate on Zn removal. The surface morphology of GCC adsorbent was characterized by Fourier transform infrared spectroscopy. Experimental results showed that GCC adsorbent could perform effectively in a wide range of experimental conditions. However, in optimum experimental conditions, such as 150 min contact time, pH 8, and 150 g/L of adsorbent dose GCC adsorbent removes 96.45% of Zn from an aqueous solution having 30 mg/L of Zn concentration.
A Review Paper on Plant Disease Detection and Recognition by Using Deep Learning
Authors: Roy Ankit , Lipton Prof. Manoj
Published: August 2022

Abstract: We living being are mostly dependent on plant and animals as well. We don’t have much food that can even sustain for even some years for we are not the only consumers on this earth. 29% of the land where the whole living eco-system exists is not apt. to feed such a huge population. Had we no plants eaters’ bacteria’s or locust, then we might have enough resource that would last for year. My project that is PLANT DISEASE DETECTION AND RECOGNOZATION is all about that. This system will enable us to recognize the type of disease the plants are suffering from and how to diagnose and treat them as well. This system depicts us an appropriate outcome. It will enable us to five a fill depiction of the kind of disease the plant are suffering from. We can even recognize the kind of medication that will be effective in totally eradication of the disease. Plant diseases are one of the foremost important reasons that destroy plants and trees. Detecting those disease at early stages enable us to beat and treat them appropriately. It is quite more important to find the kind of disease first the to treat then unknowingly. The outcomes were 92% accurate and thus we can work on the plant right way to help our plants live even longer. After multiple test, we have come forward with such and initiative that will be a boon for the humankind. Farmers are the backbone of any nation. We cannot survive until they do not get the right price for their yields and our system will play a significant role in that.
Geometrical Analysis of White Blood Cells by Using Image Segmentation Algorithm
Authors: Mishra Saurabh , Kumari Archana
Published: August 2022

Abstract: The technique behind image analysis is based on machine learning. In order for the software to recognize specific irregularities, it doesn't matter what field of medicine (or other industry) we're thinking about. The way AI learns differs dramatically from how humans learn. It makes use of enormous image databases that the software must interpret and analyze. In the present work, geometrical features of White Blood Cells such Area, Perimeter, Orientation, and Equivalent Diameter are calculated by using Image Segmentation approach.
Diagnostic evaluation of two enzyme-linked immunosorbent assay tests for Trypanosoma cruzi infection in a Colombian population
Authors: Suescún-Carrero Sandra Helena , Monroy-Díaz Ángela Liliana , Tadger-Viloria Philippe Ferdinand , Vargas-Niño Carlos Ernesto , Medina-Alfonso Mabel Idaliana , Ramírez-López Laura Ximena
Published: August 2022

Objective: To evaluate the diagnostic accuracy of two enzyme-linked immunosorbent assay tests to determine Trypanosoma cruzi infection in a Colombian population. Material and methods: Analytical study with case-control design of a diagnostic evaluation. Sensitivity, specificity and diagnostic efficacy of total CHAGATEK ELISA and recombinant CHAGATEK ELISA were determined. Positive predictive value, negative predictive value, and positive and negative likelihood ratios were calculated. The kappa coefficient was found to estimate the concordance between the index and reference tests. The discriminatory capacity of the tests was expressed by the area under the ROC curve. Results: Of the 184 samples included in the study, 99 were negative for T. cruzi and 85 were positive according to the reference tests used. Sensitivity for total and recombinant ELISA was 97.6 % and 98.8 %, respectively; while specificity was 97.0% and 94.9%. The level of concordance of the total and recombinant ELISA was almost perfect and the discriminatory ability of the two tests were good. Conclusions: It was demonstrated that the two tests can confirm and exclude the diagnosis of Chagas disease and have a good diagnostic performance.
Síndrome de Miller-Fisher seguido por vacuna Sputnik V
Authors: Chacón-Pazmiño Ángel , Realpe-Pantoja Vicente P. , Hernández-Obando María C. , Delgado-Nacaza Gloria , Unigarro-Tapia María A. , Portillo-Miño José D.
Published: August 2022

El síndrome de Miller Fisher (SMF) definido como una variante rara del síndrome de Guillain-Barré (SGB), es caracterizado por la triada clásica de ataxia, arreflexia y oftalmoplegía. Es una polineuropatía desmielinizante resultado de una respuesta autoinmune desregulada secundaria a la infección por virus y bacterias. El SMF y SGB ha sido descrito durante la pandemia de COVID-19. Existen algunos reportes en la literatura de SGB después de la vacunación por COVID-19. En cambio, los reportes de SMF post-vacunación para SARS-COV-2 son escasos en la literatura. Se presenta paciente de 75 años de edad quien consulta por astenia, adinamia y dificultad para la deglución que progresa a dificultad respiratoria. Refiere como antecedente de importancia la aplicación de vacuna Sputnik V. Durante la estancia hospitalaria se diagnóstica mediante electromiografía más estudio de conducción nerviosa SGB variante SMF. El objetivo es exponer un SMF post-vacunación para SARS-CoV-2 con Sputnik V y resaltar la importancia de este antecedente para la vigilancia en la práctica clínica e investigaciones futuras.
RANCANGAN SISTEM PEMANENAN AIR HUJAN UNTUK RUMAH TOKO DI KECAMATAN KUTA ALAM KOTA BANDA ACEH
Authors: Zahrulichsan Zahrulichsan
Published: August 2022

Rainwater harvesting is known as one of solutions for water conservation. Rainwater harvesting decreases stormwater runoff which reduce erosion, conserve water at local level to be used later and so on. Indonesia as tropical country has great water resources, but rainwater harvesting is not common, people only let the rainwater flow to the river without intention to preserve it. This study aims to test the quality of rainwater in the district of Syiah Kuala, Banda Aceh City, then plan the design of a rainwater harvesting system for shop houses that are often found in this area. The study conducted by testing the physical parameters of rainwater quality, collecting common shop house dimension data, and rainfall data, then calculating the potential rainwater that can be harvested by hydrology analysis, and then determine the volume, design, drawing of the rainwater harvesting system. The result shows that pH ranges from 7.8 to 7.9; temperature 28-31; DHL minimum 4u / cm and maximum 20u / cm; TDS ranges from 3-9 ppm, and all of this numbers meet quality standards of PERMENKES NO 32/2017. The highest daily rainfall level was in December 2014 (77.6 mm), and the average monthly rainfall for the last 10 years is 156,321 mm. With a planned rainfall value of 30.8 mm/hour, 2 hours of rain duration, and a return period of rain of 2 years, rainwater has the potential discharge quantity of 0.8 liters/second. The dimension of the system (regarding to SNI 8153:2015) are: (1) horizon pipe 3 inch long, (2) vertical pipe it is 4 inch, and reservoir volume is 0.5 m3
CONSERVATION HISTORY OF CULTURAL AND NATURAL HERITAGE SITES IN CAPPADOCIA
Authors: SOLMAZ ŞAKAR Funda
Published: August 2022

Conservation activities of cultural heritage in Turkey were started in the late 19th century and accelerated after the second half of 20th century. In this context, inventory and registration activities were started, site and boundary definitions were carried out and administrative and organizational institutions were structured throughout the country.

These conservation activities were also expanded in Cappadocia, one of the Turkey’s first region that a National Park Long-Term Development Plan was prepared for in 1968. Moreover, boundary of conservation sites was determined in regional scale and inventory recordings of single buildings were carried out by the decision of High Council for Historic Real Estate and Monuments in 1976. Designation as a World Heritage Site in 1985, then as a National Park in 1986 strengthened the conservation status of the Cappadocia in terms of national and international level. However there has been number of regulations done through the 1990s and 2000s in the scope of conservation of the site, a special conservation law for the Cappadocia came into force in 2019.

In this study, Cappadocia as a significant cultural and natural heritage site were discussed regarding the conservation approaches and processes. The conservation history of the site was analyzed by subdividing into several periods by taking into consideration of the country’s general conservation and administrative aspects. Thus, it could be possible to monitor the conservation of Cappadocia, one of the first World Heritage Site of Turkey, in the context of historical continuity.

In order to establish a holistic approach for the conservation history of Cappadocia, decisions of the conservation councils, institutional archives, expert reports of Ministries, official reports of the meetings, structuring conditions of the plans were examined and evaluated in this study.
Gas pressure intensifying oxygen transfer to significantly improving bio-oxidation productivity of whole-cell catalysis
Authors: Hua Xia , Han Jian , Zhou Xin , XU Yong
Published: August 2022

Oxygen, as a terminal electron acceptor, is an essential substrate in
the aerobic bio-oxidation process, affecting bacterial vitality and
bio-oxidation performance. In this study, a new and smart platform
biotechnology of sealed-oxygen supply bioreactor (SOS-BR) was developed
by improving gas pressure to significantly intensify oxygen transfer
rate and resolving the formidable barriers of aerobic catalysis. In
virtue of SOS-BR, the bio-productivity was greatly improved for three
representative substrates (xylose, furfural, glycerol) bio-oxidation
with the whole-cell catalysis of Gluconobacter oxydans. The
determination of oxygen transfer coefficient (KLα) established an
upgraded theoretical dynamic model for gas pressure intersification
biosystem. Additionally, viscosity measurement and combined pressure
control strategy explained the inflection point phenomenon of
productivity and confirmed the intensify mechanism. The new strategy of
significantly intensifying oxygen transfer provided insightful ideas for
overcoming the subbon obstacle of obligate aerobic catalysis, and
further promoted industrial practicability of bio-oxidation.
Adverse complications of Frozen elephant trunk, do we have enough quality data?
Authors: Howard Callum , Al-Tawil Mohammed , Geragotellis Alexander , Abdelhaliem Amr
Published: August 2022

Frozen elephant trunk (FET) has in recent times become a mainstay for
total arch replacement (TAR) in aortovascular surgery and is indicated
in order to treat a spectrum of complex aortic pathologies. However,
despite associated excellent post-operative results it is incredibly
important to recognise potential adverse complications such as negative
aortic remodelling, endoleak and distal stent-graft induced new entry so
that outcomes can be further improved. Below we provide commentary on a
recent article in the Journal of Cardiac Surgery discussing the topic.
Despite the fascinating outcomes of this systematic review and
meta-analysis the heterogeneity of the literature regarding these
adverse outcomes remains an issue which can only be solved with large
multi-centre trials directly comparing graft types as well as
indications for surgery.
ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth
Authors: Sayed Sapna , Song Jiaxing , Wang Ling , Liu Boxin , Su Zijie , Huan Li , Xue Vivian Weiwen , Liu Shan-Shan , Chen Xianxiong , Zhou Guangqian , Sun Qi , Lu Desheng
Published: August 2022

Background and Purpose: ISX9 is a neurogenesis-promoting small molecule
compound which can upregulate the expression of NeuroD1 and induce
differentiation of neuronal, cardiac and islet endocrine progenitors. So
far, the molecular mechanisms underlying the action of ISX9 still remain
elusive. Experimental Approach: To identify a novel agonist of the
Wnt/β‐catenin, a cell-based SuperTOPFlash reporter system was used to
screen known-compound libraries. An activation effect of ISX9 on the
Wnt/β‐catenin pathway was analysed with the SuperTOPFlash or
SuperFOPFlash reporter system. Effects of ISX9 on Axin1/LRP6 interaction
were examined using a mammalian two-hybrid system,
co‐immunoprecipitation, microscale thermophoresis (MST), emission
spectra and mass spectroscopy assays. The expression of Wnt target and
stemmness marker genes were evaluated with real‐time PCR and
immunoblotting. In vivo hair regeneration abilities of ISX9 were
analysed by immunohistochemical staining, real‐time PCR and
immunoblotting in hair regrowth model using C57BL/6J mice. Key Results:
In this study, ISX9 was identified as a novel agonist of the
Wnt/β‐catenin pathway. ISX9 targeted Axin1 by covalently binding to its
N-terminal region and potentiated the LRP6-Axin1 interaction, thereby
resulting in the stabilization of β‐catenin and upregulation of Wnt
target genes and stemmness marker genes. Moreover, the topical
application of ISX9 markedly promoted hair regrowth in C57BL/6J mice and
induced hair follicle transition from telogen to anagen via enhancing
Wnt/β‐catenin pathway. Conclusions and Implications: Taken together, our
study unraveled that ISX9 could activate Wnt/β‐catenin signaling by
potentiating the association between LRP6 and Axin1, and may be a
promising therapeutic agent for alopecia treatment
Watery cyst of right ventricle
Authors: Tan wei , Li Jinping , Wang Li , Yu Fengxu
Published: August 2022

A 65-year-old female presented to our center with exhaustion and
shortness of breath after daily exercise for two months. On physical
examination, vital signs were stable. All laboratory results were
unremarkable. Transthoracic Echocardiogram showed a round hypoechoic
mass (2.3cm  2.6cm) under the tricuspid valve with clear margins, part
of which closely connected with the right ventricular wall (Figure 1 A)
and there was no blood flow signal inside (Figure 1 B). The mass does
not communicate with the heart’s chambers and can affect blood flow in
the inflow tract of the right ventricle. Contrast-enhanced computed
tomography revealed a low-density round mass in the right ventricle, and
it does not enhance after the injection of intravenous contrast media
(Figure 1 C). The patient underwent right ventricular mass resection
under cardiopulmonary bypass. The tricuspid valve was suspended during
the operation to expose the cyst below the tricuspid valve. The cyst
wall is almost transparent (Figure 1D). Approximately 7 ml of pellucid
fluid withdraw with a syringe from the cyst (Figure 1 E1). Then the
exposed cyst wall was then wholly resected (Figure 1 E2), but part of
the cyst wall is the wall of the right ventricle, this part cannot be
removed. The patient had an uneventful postoperative recovery.
Histopathological examination revealed that the cystic wall was covered
by low cuboidal epithelium, and the cystic wall was glassy fibrous
tissue, consistent with cystic changes (Figure 1 F). The right
ventricular watery cyst is a rare intracardiac cyst that can easily be
mistaken for a myxoma. Whether such cysts will recur is worthy of our
long-term follow-up attention.