bluuebunny/crossref_metadata_2025 huggingface dataset:
Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation
Authors: Isei Michael O. , Crockett Meredith , Chen Emily , Rodwell-Bullock Joel , Carroll Trae , Girardi Peter A. , Nehrke Keith , Johnson Gail V. W.
Published: January 2025

Neurodegenerative diseases are often characterized by mitochondrial dysfunction. In Alzheimer’s disease, abnormal tau phosphorylation disrupts mitophagy, a quality control process through which damaged organelles are selectively removed from the mitochondrial network. The precise mechanism through which this occurs remains unclear. Previously, we showed that tau which has been mutated at Thr-231 to glutamic acid to mimic an Alzheimer’s-relevant phospho-epitope expressed early in disease selectively inhibits oxidative stress-induced mitophagy in Caenorhabditis elegans. Here, we use immortalized mouse hippocampal neuronal cell lines to extend that result into mammalian cells. Specifically, we show that phosphomimetic tau at Ser-396/404 (EC) or Thr-231/Ser-235 (EM) partly inhibits mitophagy induction by paraquat, a potent inducer of mitochondrial oxidative stress. Moreover, a combination of immunologic and biochemical approaches demonstrates that the levels of the mitophagy receptor FKBP8, significantly decrease in response to paraquat in cells expressing EC or EM tau mutants, but not in cells expressing wildtype tau. In contrast, paraquat treatment results in a decrease in the levels of the mitophagy receptors FUNDC1 and BNIP3 in the presence of both wildtype tau and the tau mutants. Interestingly, FKBP8 is normally trafficked to the endoplasmic reticulum during oxidative stress induced mitophagy, and our results support a model where this trafficking is impacted by disease-relevant tau, perhaps through a direct interaction. We provide new insights into the molecular mechanisms underlying tau pathology in Alzheimer’s disease and highlight FKBP8 receptor as a potential target for mitigating mitochondrial dysfunction in neurodegenerative diseases.
The survey of vaccination hesitancy among the residents in Jinan
Authors: Wang Dabing , Chen Shiyu , Cui Gaoyu , Wang Dequan , Liu Hong , Zhao Lihui , Wang Xiang , Chen Yuewei
Published: January 2025

Introduction

Vaccination is an important way to prevent disease, but vaccine hesitancy will impact vaccine coverage and indirectly affect health. This study aims to survey the status of vaccine hesitancy among adults in Jinan.

Methods

A cross-sectional study was conducted using the vaccine hesitancy scale among the parents of children and teenagers at hospitals in Jinan, China. We described the attitude of the parents to the vaccination through the dimensions of confidence (items: L1-L7) and the risk (items:L8-L10).The participants will be regarded as lacking confidence if the score is over 21 among the items (L1-L7), and participants will consider the vaccination to be a “Risk” if the score is over 9 among the items (L8-L10). Using the chi-square test to analyse the differences of attitude between different participants.

Results

202 individuals were enrolled, and most respondents (88.70%) agreed that vaccines are important for their child’s health. 33.50% agreed and strongly agreed that new vaccines carried more risks than older vaccines. The average score for the lack of confidence in the vaccination was 11±0.25. The average score for risk for vaccination was 9.92±0.04. Participants aged below 30 years, females, those with lower education, and those without medical workers in the family were more concerned about the risks of vaccines.

Conclusions

Participants were confident about the vaccination. But they were also concerned about the risks of vaccines. A lack of vaccine knowledge may led the participants to have hesitancy about vaccinations.
Development and validation of the health education demand scale for HPV infected patients based on KANO model
Authors: Zhang Yuying , Luo Li , Du Shuaihui , Hou Die , Zhang Yaling , He Limin , Zhou Lihua
Published: January 2025

Objective

The purpose of this study is to develop and validate the scale of health education demand of patients with HPV infection based on KANO model, so as to provide a tool for further exploring the types of health education demand and influencing factors of patients with HPV infection.

Methods

This study is a scale development and validation study using a three-stage cross-sectional design. In stage 1, a preliminary item pool is formed using literature review, semi-structured interviews and the Delphi method. In stage 2, six experts were invited to assess content validity. A cross-sectional survey was conducted on 1169 patients with HPV infection, Questionnaire results from 583 patients were used for exploratory factor analysis. In stage 3, the remaining 586 patients to validate the factor structure through confirmatory factor analysis.

Results

In stage 1, an initial 35-item scale was developed and the items were transformed positive and reverse based on KANO model. In stage 2, Exploratory factor analysis formed a scale of 28 items in 5 factors: disease information demand, social support, emotional demand, family support and health education style demand. Cronbach’s alpha was 0.940 for the entire scale and 0.763~0.908 for the five subscales in the positive items, 0.955 for the entire scale and 0.739~0.946 for the five subscales in reverse items. The content validity index of the scale: S-CVI/UA = 0.91, S-CVI/Ave = 0.98. In stage 3, the confirmatory factor analysis showed that the χ2/df, RMSEA, CFI and TLI of the positive items after four model modifications were 3.650, 0.067, 0.901, 0.888, and the SRMR value was < 0.001. The fitting of the five-factor model was good.

Conclusion

The KANO model based questionnaire on health education demand of HPV infected patients has good reliability and validity, and is suitable for the investigation of health education demand of HPV infected patients.
Incorporating earned value management into income statements to improve project management profitability and elevate application in the business and management
Authors: Setyopurnomo Rudy , Wiryono Sudarso Kaderi , Lestari Yuliani Dwi , Sukarno Subiakto
Published: January 2025

Our goal is to improve Project Management (PM) profitability and reduce discrepancies in information among stakeholders, which can result in conflicts. This will be accomplished by incorporating Earned Value Management (EVM) with the Income Statement and incorporating earnings before interest, tax, depreciation, and amortization (EBITDA) with the work breakdown structure (WBS). These incorporations will streamline information sharing between PM, other management professionals, and the stakeholders, ultimately fostering the application of PM within broader business and management contexts. We drew on theories from Project, Operations, Financial Management, Agency Theory, and the Theory of Performance Frontiers. We conducted multiple case studies in a shipbuilding corporation with 25 projects and an aircraft manufacturing corporation with 20 projects. Our analysis involved both qualitative and quantitative methods, ensuring the accuracy and practicality of our hypotheses and instilling confidence in our research findings. This integration addresses the information gap on profitability for non-project management professionals, empowering stakeholders to enhance project performance. This integration benefits the company by allowing the project manager and stakeholders to gain real-time insights into the project’s profitability, which enables continuous optimization of daily EBITDA by improving efficiency and productivity to achieve the project’s profitability target. This study and its innovative findings originate from the author’s unique approach, which is a significant contribution to the field of Project Management. This research focused on project management using EVM in for-profit organizations. Integrating EVM in the income statement also facilitates PM application in other management systems.
Cell recruitment and the origins of Anterior-Posterior asymmetries in the Drosophila wing
Authors: Reyes Rosalío , Rodriguez-Muñoz Rafael , Nahmad Marcos
Published: January 2025

The mechanisms underlying the establishment of asymmetric structures during development remain elusive. The wing of Drosophila is asymmetric along the Anterior-Posterior (AP) axis, but the developmental origins of this asymmetry is unknown. Here, we investigate the contribution of cell recruitment, a process that drives cell fate differentiation in the Drosophila wing disc, to the asymmetric shape and pattern of the adult wing. Genetic impairment of cell recruitment in the wing disc results in a significant gain of AP symmetry, which results from a reduction of the region between longitudinal vein 5 and the wing margin (L5-M) in the adult wing. Morphometric analysis confirms that blocking of cell recruitment results in a more symmetric wing with respect to controls, suggesting a contribution of cell recruitment to the establishment of asymmetry in the adult wing. In order to verify if this phenotype is originated during the time in which cell recruitment occurs during larval development, we examined the expression of a reporter for the selector gene vestigial (vg) in the corresponding pro-vein regions of the wing disc, but our findings could not explain our findings in adult wings. However, the circularity of the Vg pattern significantly increases in recruitment-impaired wing discs, suggesting that cell recruitment may contribute to AP asymmetries in the adult wing shape by altering the roundness of the Vg pattern. We conclude that cell recruitment, a widespread mechanism that participates in growth and patterning of several developing systems, may contribute, at least partially, to the asymmetric shape of the Drosophila wing.
Investigation of alpha-glucosidase inhibition activity of Artabotrys sumatranus leaf extract using metabolomics, machine learning and molecular docking analysis
Authors: Rosa Dela , Elya Berna , Hanafi Muhammad , Khatib Alfi , Budiarto Eka , Nur Syamsu , Surya Muhammad Imam
Published: January 2025

One way to treat diabetes mellitus type II is by using α-glucosidase inhibitor, that will slow down the postprandial glucose intake. Metabolomics analysis of Artabotrys sumatranus leaf extract was used in this research to predict the active compounds as α-glucosidase inhibitors from this extract. Both multivariate statistical analysis and machine learning approaches were used to improve the confidence of the predictions. After performance comparisons with other machine learning methods, random forest was chosen to make predictive model for the activity of the extract samples. Feature importance analysis (using random feature permutation and Shapley score calculation) was used to identify the predicted active compound as the important features that influenced the activity prediction of the extract samples. The combined analysis of multivariate statistical analysis and machine learning predicted 9 active compounds, where 6 of them were identified as mangiferin, neomangiferin, norisocorydine, apigenin-7-O-galactopyranoside, lirioferine, and 15,16-dihydrotanshinone I. The activities of norisocorydine, apigenin-7-O-galactopyranoside, and lirioferine as α-glucosidase inhibitors have not yet reported before. Molecular docking simulation, both to 3A4A (α-glucosidase enzyme from Saccharomyces cerevisiae, usually used in bioassay test) and 3TOP (a part of α-glucosidase enzyme in human gut) showed strong to very strong binding of the identified predicted active compounds to both receptors, with exception of neomangiferin which only showed strong binding to 3TOP receptor. Isolation based on bioassay guided fractionation further verified the metabolomics prediction by succeeding to isolate mangiferin from the extract, which showed strong α-glucosidase activity when subjected to bioassay test. The correlation analysis also showed a possibility of 3 groups in the predicted active compounds, which might be related to the biosynthesis pathway (need further research for verification). Another result from correlation analysis was that in general the α-glucosidase inhibition activity in the extract had strong correlation to antioxidant activity, which was also reflected in the predicted active compounds. Only one predicted compound had very low positive correlation to antioxidant activity.
Research on the mechanism by which digital transformation peer effects influence innovation performance in emerging industries: A case study of China’s photovoltaic industry
Authors: Zhang Aiqin , Guo Xiaoqiang , Zhang Wenjie , Liu Zhangliang
Published: January 2025

The exploration of digital transformation peer effects on the innovation performance of emerging industries is crucial for analyzing the underlying mechanisms of digital transformation, optimizing resource allocation among peer enterprises, and enhancing industrial competitiveness. This study empirically examines the influence of digital transformation peer effects on the innovation performance of the photovoltaic industry, using data from 150 photovoltaic companies listed in Shanghai and Shenzhen between 2011 and 2022. The study found that: (1) The digital transformation of the photovoltaic industry is influenced by regional and industry-specific peer effects. Regional peer effects in digital transformation have a positive impact on the innovation performance of the photovoltaic industry, while industry-specific peer effects exert a negative impact on innovation performance. Moreover, these effects exhibit dynamic persistence; (2) Further analysis of the transmission mechanism reveals that the digital transformation peer effect positively influences the innovation performance of the photovoltaic industry, primarily through the mediating role of enhanced absorptive capacity. Additionally, the level of marketization and executive tenure significantly moderate this relationship; (3) The study further investigates the photovoltaic industry within the context of subsidy policy implementation, firm types, and strategic pacing. The results indicate that the digital transformation peer effect on innovation performance is most pronounced for technology-intensive firms adopting an analytical strategy after the withdrawal of photovoltaic subsidies. For labor-intensive firms employing a defensive strategy, the peer effect is more significant before the withdrawal of subsidies. In contrast, the negative impact of industry-specific digital transformation peer effects on innovation performance is more evident in photovoltaic companies that pursue an offensive strategy; (4) The heterogeneity analysis reveals that the digital transformation peer effect on innovation performance is more significant for small-scale photovoltaic enterprises with state-owned property rights. In contrast, the peer effect negatively impacts innovation performance in large-scale photovoltaic enterprises. These findings provide theoretical insights and practical guidance for governments and enterprises in formulating digital transformation strategies for emerging industries.
Self-efficacy and career intention: Uncovering the underlying processes
Authors: Chowdhury Md. Sohel , Hossain Md. Shakhawat , Hossain Md. Alamgir , Wu Renhong
Published: January 2025

This study aims to suggest and empirically evaluate a conceptual framework that investigates the association of career self-efficacy with career intentions, emphasizing on the specific and sequential mediating mechanisms of two psychological constructs: person-environment (P-E) fit and career attitudes. Relationships among the constructs were hypothesized based on the relevant literature and were examined with AMOS and SPSS Process Macro using survey data collected from a sample of 341 job seekers in Bangladesh. Results showed that P-E fit and career attitudes each partially mediated the relationship between career self-efficacy and career intentions. Noticeably, both the mediators, together in sequence, completely mediated the above relationship. In light of the ensuring chain mediating role of P-E fit and career attitudes, a thorough understanding of the effects of self-efficacy on career intentions not only contributes to the existing literature, but also provides notable implications for career counselors and HR managers in today’s competing firms.
Trophic ecology in an anchialine cave: A stable isotope study
Authors: Durán Brenda , Álvarez Fernando
Published: January 2025

The analysis of carbon and nitrogen stable isotopes (δ13C and δ15N) has been widely used in ecology since it allows to identify the circulation of energy in a trophic network. The anchialine ecosystem is one of the less explored aquatic ecosystems in the world and stable isotope analysis represents a useful tool to identify the routes through which energy flows and to define the trophic niches of species. Sampling and data recording was conducted in one anchialine cave, Cenote Vaca Ha, near the town of Tulum, Quintana Roo, Mexico, where seven stygobitic species endemic to the anchialine caves of the Yucatan Peninsula, plus sediment, water and vegetation samples were analyzed to determine what the main nutrient sources are. We compared our results with two previous studies, one conducted in the same cave and another one from a cave in the same area, both based on the same seven species which are widely distributed in the area. Our study revealed: a) that despite a certain amount of variation in the δ13C and δ15N values of the species through time, both seasonally and interannually, the anchialine isotopic niche is much conserved; b) through contribution models we propose what are the most probable food sources for the studied species and the results confirm previous trophic classifications; and c) that the shrimp Typhlatya pearsei presents very negative δ13C values, suggesting their consumption of bacterial sources consistent with a chemosynthetic origin of organic matter. The implications of the new findings show a very stable ecosystem with the shrimp Typhlatya pearsei, as the key species to link chemosynthetic microbial production of organic matter to the anchialine trophic web.
Creating a culture, not just a space—A qualitative investigation into reflective practice groups in inpatient mental health settings from the perspectives of facilitators and attendees
Authors: Yiu Pui Lok Joshua , McDonogh Abbie , Gill Harpreet , Billings Jo
Published: January 2025

Background

Working in inpatient mental health settings is often characterised by highly emotive work and staff shortages. Despite the suggested benefits of reflective practice groups on staff well-being and clinical practice across healthcare settings, to date, there have been limited empirical studies on reflective practice groups in inpatient mental health settings, especially on group engagement and improvement.

Methods

We interviewed fifteen participants, including both facilitators and attendees of reflective practice groups. Participants were from eight inpatient mental health wards across two National Health Service settings in the UK. We analysed interview transcripts using thematic analysis.

Result

We deductively organised the data into themes and subthemes under three overarching domains–“Impact”, “Factors on Engagement”, and “Improvement”. Theme development was generated inductively from the data. For impacts, we found reflective practice groups may bolster staff reflective capacity and team cohesion. The groups may help attendees create appropriate distance from their emotions and overcome power hierarchies. We discovered that the availability of reflective practice, sense of containment in groups, and team composition may influence group facilitation and engagement. For improvements, different measures could be adopted to improve access and engagement of staff with difficulties attending. Facilitators may benefit from more support to establish a reflective culture and experiment with new ways of facilitating.

Discussion

Our findings add to the growing evidence base of the potential value of reflective practice groups in inpatient settings and elaborate on novel mechanisms of their potential impact. This study highlights changeable factors for engagement, concrete recommendations for improvements, and opportunities for further research.
Backbone extraction through statistical edge filtering: A comparative study
Authors: Yassin Ali , Cherifi Hocine , Seba Hamida , Togni Olivier
Published: January 2025

The backbone extraction process is pivotal in expediting analysis and enhancing visualization in network applications. This study systematically compares seven influential statistical hypothesis-testing backbone edge filtering methods (Disparity Filter (DF), Polya Urn Filter (PF), Marginal Likelihood Filter (MLF), Noise Corrected (NC), Enhanced Configuration Model Filter (ECM), Global Statistical Significance Filter (GloSS), and Locally Adaptive Network Sparsification Filter (LANS)) across diverse networks. A similarity analysis reveals that backbones extracted with the ECM and DF filters exhibit minimal overlap with backbones derived from their alternatives. Interestingly, ordering the other methods from GloSS to NC, PF, LANS, and MLF, we observe that each method’s output encapsulates the backbone of the previous one. Correlation analysis between edge features (weight, degree, betweenness) and the test significance level reveals that the DF and LANS filters favor high-weighted edges while ECM assigns them lower significance to edges with high degrees. Furthermore, the results suggest a limited influence of the edge betweenness on the filtering process. The backbones global properties analysis (edge fraction, node fraction, weight fraction, weight entropy, reachability, number of components, and transitivity) identifies three typical behavior types for each property. Notably, the LANS filter preserves all nodes and weight entropy. In contrast, DF, PF, ECM, and GloSS significantly reduce network size. The MLF, NC, and ECM filters preserve network connectivity and weight entropy. Distribution analysis highlights the PU filter’s ability to capture the original weight distribution. NC filter closely exhibits a similar capability. NC and MLF filters excel for degree distribution. These insights offer valuable guidance for selecting appropriate backbone extraction methods based on specific properties.
Potential associations of selected polymorphic genetic variants with COVID-19 disease susceptibility and severity
Authors: Mózner Orsolya , Szabó Edit , Kulin Anna , Várady György , Moldvay Judit , Vass Vivien , Szentesi Andrea , Jánosi Ágoston , Hegyi Péter , Sarkadi Balázs
Published: January 2025

In this study, we analyzed the potential associations of selected laboratory and anamnestic parameters, as well as 12 genetic polymorphisms (SNPs), with clinical COVID-19 occurrence and severity in 869 hospitalized patients. The SNPs analyzed by qPCR were selected based on population-wide genetic (GWAS) data previously indicating association with the severity of COVID-19, and additional SNPs that have been shown to be important in cellular processes were also examined. We confirmed the associations of COVID-19 with pre-existing diabetes and found an unexpected association between less severe disease and the loss of smell and taste. Regarding the genetic polymorphisms, a higher allele frequency of the LZTFL1 and IFNAR2 minor variants significantly correlated with greater COVID-19 disease susceptibility (hospitalization) and severity, and a similar tendency was observed for the RAVER1 and the MUC5B variants. Interestingly, the ATP2B4 minor haplotype, protecting against malaria, correlated with an increased disease susceptibility, while in diabetic patients disease susceptibility was lower in the presence of a reduced-function ABCG2 transporter variant. Our current results, which should be reinforced by larger studies, indicate that together with laboratory and anamnestic parameters, genetic polymorphisms may have predictive value for the clinical occurrence and severity of COVID-19.
Optimization of carbon footprint management model of electric power enterprises based on artificial intelligence
Authors: Wu Liangzheng , Li Kaiman , Huang Yan , Wan Zhengdong , Tan Jieren
Published: January 2025

This study intends to optimize the carbon footprint management model of power enterprises through artificial intelligence (AI) technology to help the scientific formulation of carbon emission reduction strategies. Firstly, a carbon footprint calculation model based on big data and AI is established, and then machine learning algorithm is used to deeply mine the carbon emission data of power enterprises to identify the main influencing factors and emission reduction opportunities. Finally, the driver-state-response (DSR) model is used to evaluate the carbon audit of the power industry and comprehensively analyze the effect of carbon emission reduction. Taking China Electric Power Resources and Datang International Electric Power Company as examples, this study uses the comprehensive evaluation method of entropy weight- technique for order preference by similarity to ideal solution (TOPSIS). China Electric Power Resources Company has outstanding performance in promoting renewable energy, with its comprehensive evaluation index rising from 0.5458 in 2020 to 0.627 in 2022, while the evaluation index of Datang International Electric Power Company fluctuated and dropped to 0.421 in 2021. The research conclusion reveals the actual achievements and existing problems of power enterprises in energy saving and emission reduction, and provides reliable carbon information for the government, enterprises, and the public. The main innovation of this study lies in: using artificial intelligence technology to build a carbon footprint calculation model, combining with the data of International Energy Agency Carbon Dioxide (IEA CO2) emission database, and using machine learning algorithm to deeply mine the important factors in carbon emission data, thus putting forward a carbon audit evaluation system of power enterprises based on DSR model. This study not only fills the blank of carbon emission management methods in the power industry, but also provides a new perspective and basis for the government and enterprises to formulate carbon emission reduction strategies.
De novo transcriptome assembly and discovery of drought-responsive genes in white spruce (Picea glauca)
Authors: Ribeyre Zoé , Depardieu Claire , Prunier Julien , Pelletier Gervais , Parent Geneviève J. , Mackay John , Droit Arnaud , Bousquet Jean , Nolet Philippe , Messier Christian
Published: January 2025

Forests face an escalating threat from the increasing frequency of extreme drought events driven by climate change. To address this challenge, it is crucial to understand how widely distributed species of economic or ecological importance may respond to drought stress. In this study, we examined the transcriptome of white spruce (Picea glauca (Moench) Voss) to identify key genes and metabolic pathways involved in the species’ response to water stress. We assembled a de novo transcriptome, performed differential gene expression analyses at four time points over 22 days during a controlled drought stress experiment involving 2-year-old plants and three genetically distinct clones, and conducted gene enrichment analyses. The transcriptome assembly and gene expression analysis identified a total of 33,287 transcripts corresponding to 18,934 annotated unique genes, including 4,425 genes that are uniquely responsive to drought. Many transcripts that had predicted functions associated with photosynthesis, cell wall organization, and water transport were down-regulated under drought conditions, while transcripts linked to abscisic acid response and defense response were up-regulated. Our study highlights a previously uncharacterized effect of drought stress on lipid metabolism genes in conifers and significant changes in the expression of several transcription factors, suggesting a regulatory response potentially linked to drought response or acclimation. Our research represents a fundamental step in unraveling the molecular mechanisms underlying short-term drought responses in white spruce seedlings. In addition, it provides a valuable source of new genetic data that could contribute to genetic selection strategies aimed at enhancing the drought resistance and resilience of white spruce to changing climates.
Working with words: A heuristic study into the companionship of visual art-making and intuitive prose
Authors: Sager Leigh
Published: January 2025

This article delves into a heuristic research exploration through art-based inquiry examining the symbiotic relationship between art-making and writing, revealing profound insights into the author’s creative synthesis as a reflection of self. The study explored how the interplay between words and images might facilitate an enhanced art therapy experience, particularly relevant for trauma resolution. Outcomes suggest that using ‘intuitive prose’ writing, a method developed by the author, alongside expressive art-making appeared to foster recognition of the authentic self, integration of previously hidden emotions, connection with transpersonal awareness, the ability to re-enter art-making more seamlessly and an improved tolerance to a both/and mindset. Self-study gleaned three implications for practice: pairing art-making and writing deepens the noticing of unconscious emergent themes, prolongs the staying with and revisiting of emotional states, and supports the integration of meaning-making. Ethical approaches in further research and potential applications to therapeutic client work are noted.
Optimal Population Screening Strategies for Liver Fibrosis Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease
Authors: Kim W. Ray , Mannalithara Ajitha , Charu Vivek , Chung Nakia , Kwong Allison , Kwo Paul Y. , Torok Natalie J. , Asch Steven M. , Kim Sun H.
Published: January 2025

INTRODUCTION:

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an important public health threat, potentially leading to chronic liver disease and liver cancer. Current guidelines recommend using the Fibrosis-4 score for initial identification of subjects at risk of future complications. We formulate a novel population screening strategy based on the Steatosis-Associated Fibrosis Estimator (SAFE) score, recently developed for MASLD risk stratification in primary care.

METHODS:

We interrogated the National Health and Nutrition Examination Survey data, 2017–20, in which a sample of subjects representative of US civilian population underwent vibration-controlled transient elastography (VCTE). The current guideline and a new, SAFE-based proposal were applied to these data to project the number of subjects to be diagnosed with liver fibrosis gauged by liver stiffness measurement (LSM), including significant (LSM ≥8 kPa) and advanced (LSM ≥12 kPa) fibrosis, as well as the number of VCTEs to be performed.

RESULTS:

In the survey data, 2,691 subjects, projecting to 75.8 million US adults, were found to have MASLD, of whom 11% had LSM 8–12 kPa and 6% LSM ≥12 kPa. When the current guideline was applied, 18.1 million VCTEs would be needed to diagnose 3.5 million subjects with LSM ≥8 kPa and 1.7 million subjects with LSM ≥12 kPa. In comparison, a new approach based on the SAFE score would detect 4.9 million with LSM ≥8 kPa and 2.5 million subjects with LSM ≥12 kPa (37% and 45% improvement over the current guideline, respectively), while requiring 5.0 million fewer VCTEs (28% reduction).

DISCUSSION:

The proposed population risk stratification approach using the SAFE score is simpler and substantially more effective, yielding more subjects with liver fibrosis while requiring less resources compared with the currently recommended algorithm.
Islamic Religious Education Curriculum Innovation: Fethullah Gülen's Perspective
Authors: Muhamad Restu Fauzi  , Tasman Hamami  , Hyung-Jun Kim
Published: January 2025

Purpose – This study aims to (1) Formulate what is the ideal orientation of Islamic religious education according to Fethullah Gülen and (2) Formulate Islamic religious education curriculum innovations from the Gülen perspective in the realm of objectives, materials, media, methods, and evaluations.
Design/methods/approach – This study was a literature research. The source of data in this study was the works of Gülen. The data collection method used the documentation method. The data analysis method used the content analysis method through several stages of reading the entire data, encoding, code sorting, finding relationships between categories, and formulating the meaning.
Findings – The findings were (1) The ideal Islamic religious education, according to Gülen, should include educating and shaping individual character, and (2) The purpose of the Islamic religious education curriculum, according to Gülen, is to create Islamic religious education that is relevant to the times, high in quality, and strengthening the identity of Muslims; Learning materials comprise content expansion that integrates classical religious texts with contemporary science; Learning media must make Islamic religious education more interesting and challenging for students so that they are more interested in learning Islam; The learning method involves students actively and collaboratively in the learning process; and Curriculum evaluation includes aspects of the quality of learning materials, learning methods, and learning outcomes.
Research implications/limitations – The research has implications for developing Islamic religious education curricula that focus on a more inclusive, moderate, and relevant approach to the needs of the times. It can affect the way schools educate, encourage intercultural dialogue, and promote universal values such as tolerance and peace.
Originality/value – This study has explored Gülen's perspective on the innovation of the Islamic religious education curriculum. By examining its perspective, this research provides new insights and presents a unique perspective on curriculum development.
Album studiosorum szczecińskich szkół akademickich i jego edycje
Authors: Borysowska Agnieszka
Published: January 2025

Artykuł ma na celu opisanie zadania związanego z opracowaniem dwóch form edycji zabytkowych matrykuł ze zbiorów Książnicy Pomorskiej w Szczecinie, zrealizowanego przez pracowników biblioteki. Może on stanowić inspirację dla opiekunów cymeliów z innych instytucji. Dodatkowym celem jest popularyzacja wiedzy na temat tych źródeł oraz ich potencjalnego wykorzystania – zarówno w formie oryginalnej, jak i opracowanej – przez badaczy i innych zainteresowanych. W tekście zastosowano metodę opisową. Scharakteryzowano pokrótce zabytkowe dokumenty, w tym ich historię, zawartość oraz wartość źródłową, omówiono też założenia dwóch form edycji, które dają użytkownikom różne możliwości przeszukiwania i analizy danych zawartych w dokumentach pierwotnych. Wyniki i wnioski: W artykule wyjaśniono motywy podjęcia zadania edytorskiego. Należą do nich: 1) przywrócenie chronionych dokumentów do obiegu naukowego oraz 2) realizacja obowiązku badania zbiorów i upowszechniania ich wyników, co jest zadaniem pracowników bibliotek naukowych. Wskazano na różnice między dwiema formami edycji, ich zalety i wady, a także na to, jak wzajemnie się uzupełniają. Największą zaletą edycji książkowych jest prezentacja pełnej treści i oddanie struktury dokumentów wraz z wprowadzeniem i przekładem elementów narracyjnych źródeł; natomiast baza danych umożliwia szybkie przeszukiwanie treści za pomocą różnych kategorii wyszukiwawczych oraz aktualizację danych w miarę pojawiania się nowych ustaleń. Wadą edycji książkowych jest ograniczona możliwość przeszukiwania treści – jedynie za pomocą indeksów osobowych i miejscowych – oraz jej zamknięta, skończona forma. W przypadku bazy danych wadą jest brak niektórych elementów oryginalnych dokumentów oraz mniejsza trwałość formy elektronicznej w porównaniu z drukiem. Artykuł wskazuje także na możliwości bibliotek naukowych dotyczące realizacji i trwałego zabezpieczenia wyników tego rodzaju projektów
Cundisiusowie: pracownicy książki we Wschowie i Lesznie w XVII i XVIII wieku
Authors: Szymańska Kamila
Published: January 2025

Celem artykułu jest próba przedstawienia dziejów rodziny pracowników książki – Cundisiusów, parających się działalnością wydawniczą, księgarską i introligatorstwem we Wschowie i Lesznie na przełomie XVII i XVIII wieku. W wyniku analizy niekompletnych materiałów zebranych na podstawie przeprowadzonych kwerend archiwalnych, bibliograficznych oraz w literaturze przedmiotu udało się ustalić losy kilku przedstawicieli rodziny. Najpełniej zaprezentowana została postać Johanna Kuntzego (1626–1700), posługującego się zlatynizowaną formą nazwiska, który – urodzony w Merseburgu, czynny zawodowo w Görlitz – przed 1669 rokiem osiadł we Wschowie. Tu ogłosił relację z wizyty Augusta II w tym mieście. Zapewne jego wnukiem był introligator w Lesznie Johann Gottfried (zm. 1769), znany z wydania trzech edycji śpiewnika dla użytku parafii luterańskiej w Lesznie. Pozostali przedstawiciele rodziny zajmowali się jedynie oprawą książek. Wnioski: W świetle dostępnych danych wiadomo, że Cundisiusowie zdominowali rynek książki we Wschowie i Lesznie w XVIII wieku w zakresie oprawy książek. U schyłku stulecia pozycja rodziny uległa obniżenium ze względu na zmiany w produkcji i handlu książką.
Działalność wydawnicza w Poznaniu w latach 1945–1950: odrodzenie i upadek
Authors: Jazdon Artur
Published: January 2025

W artykule została przedstawiona produkcja wydawnicza Poznania w latach 1945–1950, czyli w okresie odbudowy po odzyskaniu przez Polskę niepodległości. Celem artykułu jest ukazanie jej rozwoju w pierwszych trzech latach, następnie powolnego upadku spowodowanego zmieniającą się sytuacją polityczną. Nowe władze dążyły do wyeliminowania z rynku wydawców prywatnych i spółdzielczych oraz prowadzenia działalności nakładczej przez inne podmioty. Zahamowanie tak prężnie rozwijającej się działalności i centralizacja ruchu wydawniczego w Warszawie doprowadziły do poważnego uszczerbku w rozwoju naukowym, kulturalnym i literackim Poznania. Metody badawcze: bibliograficzna, statystyczna i porównawcza. Podstawę analiz stanowią dane bibliograficzne dotyczące ruchu wydawniczego w Poznaniu zebrane przez autora, które porównywano z wynikami badań z lat poprzednich. Wnioski: autor wykazał, że produkcja wydawnicza Poznania lat 1945–1950 była znacznie większa niż to do tej pory przedstawiano w literaturze.
Katalogi centralne w zmieniającym się świecie bibliotek
Authors: Hollender Henryk
Published: January 2025

Katalogi centralne są normą w krajach rozwiniętych. W najszerzej rozpowszechnionym modelu zasoby metadanych przyrastają wraz z przyrostem zbiorów, drogą współkatalogowania. Celem artykułu jest ogólne przedstawienie zadań i kierunków rozwoju katalogów centralnych, ze szczególnym uwzględnieniem nowych technologii i w kontekście złożoności zarządzania przedsięwzięciami polegającymi na wdrażaniu ich nowych odmian, a także ostrzeżenie przed błędnymi rozwiązaniami. Wnioski zostały wywiedzione z obserwacji własnych oraz zapośredniczonych przez piśmiennictwo, metody były zatem empiryczne i metaempiryczne. Skupiono się na narodowych (krajowych) katalogach centralnych i podano przykłady kilku rozwiązań, poddając je ocenie, formułowanej głównie w kategoriach user experience oraz kulturowych priorytetów projektu. Rozważono zmiany, jakim katalogi podlegają przy stosowaniu Linked Open Data, i krytycznie oceniono dotychczasowe postępy. Porównano też założony w 2002 roku katalog centralny NUKAT, zdominowany przez zasoby bibliotek naukowych, oraz (konkurencyjne?) przedsięwzięcie „połączone katalogi”, któremu przewodzi Biblioteka Narodowa. Projekty zwieńczone powodzeniem, jak nowy katalog brytyjski czy szwajcarski, także oparte na zasadzie „Software as a Service”, mają przewagę nad innymi nie tyle dzięki uwzględnieniu linkowania otwartych danych, ile dzięki harmonijnemu współdziałaniu wielu instytucji. Wysnuto wniosek, że wdrożenie tej zasady w polskiej praktyce zarządzania jest kluczowe dla docelowego powodzenia polskiego katalogu.
Boussinesq’s equation for water waves: the soliton resolution conjecture for Sector IV
Authors: Charlier Christophe , Lenells Jonatan
Published: January 2025

We consider the Boussinesq equation on the line for a broad class of Schwartz initial data relevant for water waves. In a recent work, we identified ten main sectors describing the asymptotic behavior of the solution, and for each of these sectors we gave an exact expression for the leading asymptotic term in the case when no solitons are present. In this paper, we derive an asymptotic formula in Sector IV, characterized by

x

t

∈

(

1

3

,
1

)

$\frac{x}{t}\in \left(\frac{1}{\sqrt{3}},1\right)$

, in the case when solitons are present. In particular, our results provide an exact expression for the soliton-radiation interaction to leading order and a verification of the soliton resolution conjecture for the Boussinesq equation in Sector IV.
The Sobolev extension problem on trees and in the plane
Authors: Carruth Jacob , Israel Arie
Published: January 2025

Let V be a finite tree with radially decaying weights. We show that there exists a set

E
⊂

R

2

$E\subset {\mathbb{R}}^{2}$

for which the following two problems are equivalent: (1) Given a (real-valued) function ϕ on the leaves of V, extend it to a function Φ on all of V so that

‖
Φ

‖

L

1
,
p

(

V

)

${\Vert}{\Phi}{{\Vert}}_{{L}^{1,p}\left(V\right)}$

has optimal order of magnitude. Here, L
1,p
(V) is a weighted Sobolev space on V. (2) Given a function

f
:
E
→
R

$f:E\to \mathbb{R}$

, extend it to a function

F
∈

L

2
,
p

(

R

2

)

$F\in {L}^{2,p}\left({\mathbb{R}}^{2}\right)$

so that

‖
F

‖

L

2
,
p

(

R

2

)

${\Vert}F{{\Vert}}_{{L}^{2,p}\left({\mathbb{R}}^{2}\right)}$

has optimal order of magnitude.
Thyroid surgery in pediatric age: a 10-year experience at a single center and literature review
Authors: Asya Orhan , Yumusakhuylu Ali Cemal , Gundogdu Yavuz , Kuyumcu Omer Faruk , Turan Serap , Guran Tulay , Gurpinar Tosun Busra , Oysu Cagatay
Published: January 2025

Objectives

Surgery interventions for thyroid disorders are rare in pediatric population. This study aims to present our institution’s 10-year experience regarding the surgical treatment and outcomes of thyroid pathologies in children and review the literature.

Methods

All pediatric patients who underwent thyroid surgery at our institution from April 2013 to October 2023 were retrospectively reviewed.

Results

The study included 57 patients with a median age of 15 years. 38 patients (66.6 %) were female, and 19 patients (33.3 %) were male. The most common indication for thyroid surgery was a nodule (71.9 %), followed by Graves’ disease (10.5 %), multinodular goiter (8.7 %), and familial multiple endocrine neoplasia syndrome (8.7 %). Of the 57 patients, 36 (63.2 %) were diagnosed with thyroid neoplasia, with 28 (77.8 %) having papillary thyroid carcinoma (PTC), three (8.3 %) having medullary thyroid carcinoma (MTC), two (5.6 %) having follicular thyroid carcinoma (FTC). Temporary unilateral vocal cord paralysis and permanent unilateral vocal cord paralysis were seen in three patients (5.3 %) and in two patients (3.5 %) respectively. Persistent hypocalcemia and permanent hypoparathyroidism were noted in two patients (3.5 %), while transient hypocalcemia was observed in 13 patients (22.8 %). The presence of neoplasm did not appear to be associated with the incidence of hypocalcemia or vocal cord paralysis (p=0.115 and 0.652, respectively).

Conclusions

Thyroid pathologies in pediatric patients necessitate a multidisciplinary approach. Surgical management should be carefully evaluated in accordance with pediatric guidelines. Complication rate significantly decreases when surgery is performed by experienced surgeon.
Implicit offensive language taxonomy
Authors: Bączkowska Anna , Lewandowska-Tomaszczyk Barbara , Žitnik Slavko , Liebeskind Chaya , Trojszczak Marcin , Valunaite Oleskeviciene Giedre
Published: January 2025

The aim of this paper is to present a proposal of implicitness typology. The theoretical model we propose is compliant with neo-Gricean pragmatics and is explicitly designed to cover instances of offensive language on social media. The implicitness framework we propound has been empirically verified by means of a corpus-assisted analysis and computational method of word embeddings (Word2Vec and FastText), which, in principle, have supported the schema explicated here. This taxonomy is potentially applicable to the ontology of offensiveness and, thus, to NLP-based research; in particular, it can be useful for automatic detection of implicit offensive language on social media.
Yoga and chronic diseases: an umbrella review of systematic reviews and meta-analyses
Authors: Wang Feifei , Yang Wenchang , Wang Chen , Wang Kaiyue , Yu Zhongyi , Ke Dandan , Sun Liang , Gao Xiang
Published: January 2025

Introduction

With the popularity of yoga increasing as a means to improve overall well-being, this umbrella review aimed to evaluate the potential effects of yoga on chronic disease outcomes by synthesizing previously published systematic reviews, including meta-analyses, of randomized controlled trials in adult populations.

Content

PubMed, Scopus, Cochrane, Web of Science, and CINAHL for systematic reviews published up to 31st March 2023. Systematic reviews examining the effectiveness of yoga interventions compared with controllable groups on chronic disease outcomes were searched from adults aged above 18 years old. Fifty-one systematic reviews, of which 34 were with meta-analyses, were eligible. The included reviews yielded 579 individual studies with 28403 reported participants. Most studies (n=45, 86.5 %) were conducted with general adult participants, other six studies were with women diagnosed with breast cancer. Yoga interventions had strong effects on depression, blood pressure, blood glucose, and fatigue management, while weak evidence was found for pain management and arthritis.

Yoga intervention may have an effect on improvements on depression, hypertension, type 2 diabetes, and fatigue management but not beneficial for physically disordered chronic diseases.

Outlook

Future studies with larger sample sizes and longer durations are necessary to validate the effect of yoga on chornic diseases. Further exploration on yoga implementation are expected.

Primary Funding Source

JIF201036Y and JIF201018Y (PROSPERO: CRD42023417841).
Heterogeneous catalysis: an alternative approach for energy and environment
Authors: Parangi Tarun
Published: January 2025

The uncontrolled increase in population and human activities has led to a significant rise in the demand for energy resources. The excessive use of limited fuel sources, unplanned deforestation, and greenhouse gas emissions have necessitated the search for and development of alternative, sustainable energy resources that cause minimal or no harm to the environment. The introduction of green and eco-friendly technologies offers a potential solution to address the growing demand in fields such as petroleum and hydrogen production, with the ultimate goal of promoting environmental sustainability. This review article highlights recent innovations in the field of heterogeneous catalysis, focusing on the development of various catalytic materials and processes, as well as their future prospects for both industrial and academic advancements. A brief discussion is presented on the efficient performance of solid acid and base catalysts, metal-organic frameworks (MOFs), electrocatalysts, and photocatalysts. The discussed catalytic systems have been explored for their potential applications, including biodiesel and hydrogen production as alternative energy sources, as well as CO2 reduction and the degradation of toxic dyes and organic pollutants for environmental remediation. Overall, the significance of heterogeneous catalysts has been explored, emphasizing their critical role in driving industrial progress and economic growth.