bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical Evidence
Authors: Gromova O. A. , Torshin I. Yu. , Lila A. M.
Published: October 2022

In the treatment of joint diseases, including osteoarthritis (OA), the use of standardized extracts of undenatured type II collagen (UDC-II) is promising. It is known that UDC-II is involved in the regulation of innate and adaptive immunity (reduction of autoimmune reactions that stimulate cartilage degradation) and in the reduction of chronic inflammation activity (modulation of cytokines and prostaglandins). The effect of UDC-II on discoidin receptors of chondrocytes helps to prevent structural disorders of the cartilage connective tissue. Experimental and clinical studies have shown that under the influence of standardized UDC-II, there is an increase in the proportion of regulatory CD4+ T cells, a decrease in the levels of pro-inflammatory cytokines, such as interleukin (IL) 1β, IL6, tumor necrosis factor α, CRP, prostaglandins in the blood, as well as matrix metalloproteinase 3 and NF-κB expression in cartilage. The use of UDC-II in OA leads to a significant reduction in pain, an increase in the range of joint motion, an improvement in joint function according to WOMAC and quality of life.
Clinical and immunological phenotypes of systemic lupus erythematosus, identified based on cluster analysis of data from 400 patients from V.A. Nasonova Research Institute of Rheumatology
Authors: Aseeva E. A. , Lila A. M. , Soloviev S. K. , Nasonov E. L. , Glukhova S. I.
Published: October 2022

Objective: to identify clinical and immunological variants (phenotypes) of systemic lupus erythematosus (SLE) using cluster analysis.

Patients and methods. The study included 400 patients with diagnosis of SLE according to the 2012 SLICC classification criteria. Patients underwent laboratory and immunological workup according to accepted standards of medical care for patients with SLE, and therapy was prescribed in accordance with disease activity.

Results and discussion. Among patients, most were females (ratio of men and women – 1:10), and people of young age (34.2±11.5 years), with an average duration of illness of 6 [3; 12] years. In 98 (25%) patients with SLE, the disease debuted before the age of 18 years. Lupus nephritis (LN) was detected in 192 (48%) patients, SLE with antiphospholipid syndrome (APS) – in 48 (12%), SLE with Sjцgren's syndrome – in 44 (11%). For cluster analysis 30 clinical, 4 laboratory, 12 immunological and 10 therapeutic parameters were selected and a dendrogram was constructed with the calculation of the Euclidean distance using the Ward method. As a result, five clusters of SLE were identified: with the development of LN; with predominantly extrarenal manifestations; SLE combined with APS; SLE combined with Sjцgren's syndrome; SLE with a debut in childhood (up to 18 years of age). Clusters differed in clinical, laboratory and immunological parameters, as well as in therapy.

Conclusion. Cluster analysis data made it possible to group the selected signs into five clinical and immunological variants (phenotypes) of SLE. Identification of SLE phenotypes as a set of characteristics that, individually or in combination, make it possible to determine differences between patients based on clinical, laboratory and immunological parameters, variants of the onset and course of the disease, response to therapy and prognosis, will contribute to a personalized approach in choosing the therapy, improving its long-term results, as well as quality of life and prognosis in patients with SLE.
Predicting the efficacy of tofacitinib therapy based on gene expression of proinflammatory cytokines and proteases in cultured blood cells of patients with rheumatoid arthritis
Authors: Markova G. A. , Chetina E. V. , Satybaldyev A. M.
Published: October 2022

The effectiveness of personalized therapy for rheumatoid arthritis (RA) is associated with the correct choice of the drug and the ability to predict its effect before starting the treatment.

Objective: to study in patients with RA the relationship between results of therapy and initial expression of genes responsible for bone and articular cartilage resorption (matrix metalloproteinase 9 – MMP9, – cathepsin K) and inflammation (tumor necrosis factor α – TNFα – and interleukin 1β – IL1β) in mononuclear cells of peripheral blood (PBMC), cultured with tofacitinib (TOFA).

Patients and methods. We examined 12 patients with RA who had not previously received TOFA. The average age of the patients was 51 years, the average duration of the disease was 37.6 months. After 3 months of TOFA therapy, 6 patients achieved remission, while the rest had high and moderate disease activity. PBMC were isolated before therapy using a Ficoll density gradient and cultured in the presence of 100 nM TOFA for 48 h. Total RNA obtained from these cells was used to analyze the expression of MMP9, cathepsin K, IL1β, and TNFα genes using a real-time quantitative reverse transcription polymerase chain reaction.

Results and discussion. TOFA is able to modify gene expression in cultured PBMC from RA patients compared to control cells. The initial expression of all the studied genes was significantly increased in cultured with TOFA cells of patients with persistent high and moderate disease activity during therapy, while TNFα gene expression was significantly reduced in patients who achieved remission.

Conclusion. In patients with RA who have not previously received TOFA, a decrease in TNFα gene expression in blood cells cultured with this drug before the start of therapy may be a prognostic biomarker for achieving remission during TOFA therapy.
Clinical course, laboratory and instrumental markers of vascular inflammation in the Kyrgyz cohort of patients with Takayasu's arteritis
Authors: Koilubaeva G. M. , Bolotbekova A. M. , Egorova O. N. , Turatbekova A. T. , Tarasova G. M. , Suyunbai kyzy G. , Chukubaev M. A. , Turdukulov Z. E. , Usupbaeva D. A.
Published: October 2022

Lack of highly sensitive and specific methods of laboratory and instrumental diagnostics leads to difficulties in timely verification of Takayasu's arteritis (AT).

Objective: to analyze the clinical course, laboratory and instrumental markers of vascular inflammation in the Kyrgyz cohort of patients with AT.

Patients and methods. The study included 75 patients with a reliable diagnosis of AT, who were hospitalized and observed on an outpatient basis at the clinic of the National Center for Cardiology and Therapy named after acad. Mirsaida Mirrakhimova from January 2011 to April 2022. Patients were examined using clinical, laboratory and instrumental methods once every 2 years. The follow-up period was 1–5 years in 45 (60%) patients and 6–15 years in the remaining 30 (40%) patients. All patients underwent a clinical and standard laboratory work-up with CRP and interleukin 6 levels assessment, as well as ultrasound Dopplerography of peripheral arteries in the color Doppler mapping mode and multislice computed tomography-panaortography.

Results and discussion. Lesions of the common carotid (85.33%) and subclavian (84%) arteries were detected more often. Involvement of the abdominal aorta was noted in 60% of patients and was accompanied by stenosis of the renal arteries in 100% of cases. The clinical picture of the disease was mainly represented by cardiac pathology in the form of arterial hypertension (84%) and aortic regurgitation (68%) with the development of decompensated chronic heart failure in 15% of patients. During the dynamic observation, significant improvement in the course of the disease, clinical symptoms, decrease in the severity of vascular changes were not revealed, with the exception of a decrease in the clinical activity of AT (p<0.05) in one third of patients (37.4%). Conclusion. The severity of clinical manifestations and the course of AT in the Kyrgyz cohort was due to cardiovascular pathology. As dynamic observation showed, the lack of significant improvement in the course of the disease was largely due to the long duration of chronic inflammation, late diagnosis, development of irreversible stenotic, occlusive and aneurysmal changes, as well as the fact that patients did not receive adequate pathogenetic therapy at the onset of the disease. Keywords: <0.05) in one third of patients (37.4%).

Conclusion. The severity of clinical manifestations and the course of AT in the Kyrgyz cohort was due to cardiovascular pathology. As dynamic observation showed, the lack of significant improvement in the course of the disease was largely due to the long duration of chronic inflammation, late diagnosis, development of irreversible stenotic, occlusive and aneurysmal changes, as well as the fact that patients did not receive adequate pathogenetic therapy at the onset of the disease.
Back pain and assessment of ankylosing spondylitis activity during gestation: symptoms reflecting exacerbation of the disease and pregnancy
Authors: Krichevskaya O. A. , Dubinina T. V. , Ilinykh E. V. , Gluhova S. I. , Demina A. B. , Andrianova I. A. , Kulikov I. A. , Skripkina I. Iu.
Published: October 2022

Objective: to study the dynamics of back pain severity and the frequency of its individual components, characterizing the inflammatory and mechanical rhythm, on the background of gestation in women with ankylosing spondylitis (AS) and compare them with manifestations of dorsopathy in healthy pregnant women; to determine the information value of BASDAI during pregnancy, i.e. to identify its components with the optimal sensitivity and specificity ratio for assessing AS activity during gestation.

Patients and methods. The main group consisted of 49 pregnant women with AS who met the modified New York criteria of 1984. The average age of patients was 31.7±4.9 years, the average duration of the disease was 134.4±85.8 months. BASDAI for trimesters of pregnancy was: 2.3 [1.2; 4.4], 2.8 [1.4; 4.2] and 2.2 [1.6; 4.0]. The control group included 51 pregnant women with back pain associated with gestation, without rheumatic diseases. The average age was 28.0±4.4 years. The intensity of back pain was assessed on a numerical rating scale. ROC-analysis was performed with calculation of the area under the curve (AUC) of each component of BASDAI in each pregnancy trimester.

Results and discussion. More than 80% of pregnant women with AS experienced back pain, while the intensity of general back pain did not differ from that in the control group. Night back pain with improvement on awakening in the main group was present in 70%, 58% and 68.8% of women, respectively, in the I-III trimesters; its intensity was 3 [1; 5], 3.5 [3; 6] and 3.4 [2; 5] respectively; the frequency and severity of night pain were higher than in the control group. The number of women with improvement after exercise in the II and III trimesters did not differ in both groups. In the second half of pregnancy, 40% of AS patients noted improvement during rest, 52.1% – increased pain after exercise; the frequency of mechanical rhythm pain elements remained lower than in the control group. The AUC value for BASDAI in the first trimester was 0.74; AUC of all BASDAI components was >0.5. In the II and III trimesters, the AUC values for fatigue and back pain were 0.8.

Conclusion. During pregnancy the vast majority of women with AS experience back pain, the nature of which changes in the second half of gestation. Night pain that improves on awakening reflects AS activity and is not related to pregnancy. The BASDAI components of severity and duration of morning stiffness have the highest classification value during pregnancy.
Microbiota as a new pathogenetic factor in the development of chronic hyperuricemia and gout. Part I: the current state of the problem
Authors: Eliseev M. S. , Kharlamova E. N. , Zhelyabina O. V. , Lila A. M.
Published: October 2022

The gut microbiota plays a key role in metabolism and immune regulation, and imbalance in microbial composition can contribute to various diseases. We present up-to-date data on the role of the gut microbiota in the occurrence of chronic hyperuricemia (HU) and gout, which is associated with the influence of the microbiota on the synthesis of purine-metabolizing enzymes and pro-inflammatory cytokines. It has been shown that the gut microbiota plays an important role in the pathophysiology of gout and can serve as a new target for therapy. Currently, the microbial index of gout is considered as a potential method for early diagnosis of the disease, possibly already at the preclinical stage. The gut microbiota can be a starting point in the study of the pathogenesis of HU and gout. This makes it necessary to assess the pathogenetic relationship between individual specific microorganisms, the microbiota as a whole, and the development of uric acid (UA) metabolism disorders that contribute to the onset of HU and its transformation into gout. It is assumed that this approach will provide a more complete understanding of the gut microbiota participation in the synthesis of UA and its extrarenal excretion, as well as of bacteria and bacterial enzymes that can be used as a probiotic coadjuvant for the treatment and prevention of gout.
Viral mixed infection complicated by acute hepatitis and allergic toxic dermatitis (clinical case)
Authors: Aronova E. S. , Belov B. S. , Gridneva G. I.
Published: October 2022

Epstein-Barr virus (EBV) belongs to the family of herpesviruses (herpes type 4) and is one of the most common and highly contagious. During the pandemic of a new coronavirus disease, it was found that in patients previously infected with EBV, COVID-19 can cause its reactivation, which is often manifested by the clinic of acute hepatitis. The article presents a clinical case of the development of acute hepatitis in a patient with mixed infection with EBV and SARS-CoV-2 in combination with allergic toxic reaction while taking sulfasalazine prescribed for spondyloarthritis. A feature of this case was the development of severe hepatitis of mixed genesis with a favorable outcome. The importance of adherence to drug monitoring rules for newly prescribed drugs for COVID-19 was emphasized. In severe cases of the disease, the possibility of mixed infection should be taken into account.
Shared features of pathogenetic aspects, autoimmunity and pharmacotherapy in coronavirus infection (COVID-19) and immunoinflammatory rheumatic diseases
Authors: Rutskaya-Moroshan K. S. , Abisheva S. T. , Lila A. M.
Published: October 2022

The review is devoted to the relationship between the pathogenetic mechanisms of coronavirus infection (COVID-19) and immunoinflammatory rheumatic diseases (IRD). The current knowledge on the pathogenesis of COVID-19 is summarized, including the mechanisms of coagulopathy, hyperproduction of pro-inflammatory cytokines, and antiphospholipid antibodies that are common with IRD. The presence and clinical significance of detection of various autoantibodies in COVID-19, which probably play a pathogenetic role in immune dysregulation, were analyzed. Based on the data of recent studies, risk factors and features of the severe course of infection in patients with IRD are considered.
Hyaluronic acid in rheumatic disorders of the periarticular soft tissues: a brief descriptive review
Authors: Karateev A. E.
Published: October 2022

Periarticular soft tissue disorders (PSTD) are typical manifestation of immunoinflammatory rheumatic diseases, primarily spondyloarthritis. However, in real clinical practice, physicians involved in the management of patients with musculoskeletal diseases often have to deal with "non-systemic" PSTD resulting from trauma, physical exertion, or degenerative processes associated with endocrine, metabolic, and cardiovascular diseases. PSTD causes acute and chronic pain, significant impairment of function and deterioration in the quality of life. The treatment of this pathology is complex and includes non-drug methods, painkillers and local injection therapy. Hyaluronic acid (HA) drugs occupy an important place in this treatment. Their use is pathogenetically justified, because when the tendon and enthesis are involved, the internal environment (intercellular matrix) change, and its basis is natural hyaluronate, which provides the viscoelastic properties of biological structures, as well as regulates metabolism, proliferative and immune processes. A relatively low molecular weight HA drug (530–730 kDa) has favorable rheological parameters, anti-inflammatory and anabolic potential, which makes it the drug of choice for local injection therapy of PSTD. This review briefly presents data on the pathogenesis of PSTD and the advisability of HA drugs use for its therapy, as well as the evidence base for the use of HA (530–730 kDa) in various types of ligamentous apparatus lesions.
The crisis in Ukraine: another missed opportunity for building a more sustainable economic paradigm
Authors: Quitzow Rainer , Renn Ortwin , Zabanova Yana
Published: October 2022

Economic disruptions caused by the war in Ukraine provide insights into how climate change may threaten global supply chains in a not-so-distant future. The EU is addressing strategic vulnerabilities, particularly in the sphere of fossil fuel supply, while seeking to maintain its climate
ambition. However, the EU has failed to make more far-reaching changes to its economic model and relations with international partners. These are urgently needed to address the root causes of the current crisis.
Die Darstellung von (Un-)Sicherheiten zum Thema Klimawandel in Schulbuchtexten für den Geografieunterricht
Authors: Schauß Mareike , Held Hermann H. , Sprenger Sandra
Published: October 2022

Werden gesicherte Erkenntnisse sowie Unsicherheiten zum Thema Klimawandel in Schulbüchern adäquat kommuniziert und bilden sie den aktuellen Diskurs ab? Im Rahmen der Studie werden Klimawandelkapitel in Schulbüchern analysiert und Vorschläge zu Gestaltung und Struktur
von Schulbüchern entwickelt.Uncertainties are transparently presented and communicated in the Assessment Reports from the Intergovernmental Panel on Climate Change (IPCC). This study examines the extent to which textbooks reflect this discourse, in the sense of the Nature
of Science. The aim is to identify the representation of both virtually certain findings and uncertainties on the topic of climate change in textbooks. For this purpose, climate change chapters in lower and upper secondary school geography textbooks were analyzed, using qualitative content
analysis with deductive-inductive category formation according to Philipp Mayring. It was discovered that uncertainties are represented predominantly by linguistic means (e. g., subjunctive), while technical terminology (such as that of the IPCC) is hardly used. Similar results can be seen
for virtually certain findings.
Participatory scenario planning: Participatory research methods for sustainability ‐ toolkit #3
Authors: Hamann Maike , Hichert Tanja , Sitas Nadia
Published: October 2022

Achieving sustainable and equitable futures requires a sense of what those futures might look like, and how to get there. Participatory scenario planning (PSP) explores diverse future scenarios in a stakeholder-engaged process of knowledge co-production. PSP makes use of different methods
to identify relevant stakeholders, create a set of scenarios, and explore ways to connect those future visions to the present.
Wissenschaftliche Politikberatung lehren und lernen: Workshop-Serie am Institut für transformative Nachhaltigkeitsforschung
Authors: Becker Sophia , Renn Ortwin
Published: October 2022

Transformationsprozesse zu erforschen, zu verstehen und zu fördern ‐ dieses Ziel hat sich das Institut für transformative Nachhaltigkeitsforschung (IASS) in Potsdam gesetzt. Dazu zählt, Transformationsforschung und transformative Forschung zu integrieren, transdisziplinär
und ko-kreativ vorzugehen und Fellows in die Forschungs- und Beratungstätigkeiten einzubinden. Die gewonnenen Erkenntnisse will das IASS in den Dienst der Politik- und Gesellschaftsberatung stellen.
Pengaruh Harga dan Kualitas Produk terhadap Keputusan Pembelian Laptop Asus (Studi pada Pengguna Laptop Asus di Kota Semarang)
Authors: Maulida Julyan Hasna , Waloejo Handojo Djoko , Pinem Robetmi Jumpakita
Published: October 2022

Along with the development of technology, the number of laptop users makes competition for laptop market share in Indonesia increasing. Companies need a special strategy to win the competition. One way is to improve consumer purchasing decisions. This study aims to determine the effect of price and product quality on purchasing decisions for Asus laptops (study on Asus laptop users in Semarang City). This type of research is explanatory research with sampling technique using purposive sampling technique. The data collection technique used was a questionnaire. The sample in this study amounted to 100 Asus laptop users in Semarang City who had or purchased Asus laptops for at least the last 2 years. Data analysis was carried out using the SPSS 25.0 for windows application to test the validity, test reliability, test the correlation coefficient, test the coefficient of determination, simple and multiple linear regression, as well as t test and F test. The results of this study indicate that price and product quality together -the same has a positive effect on purchasing decisions, with a score of 56.994 (F Value) > 3.090 (F table).Seiring dengan perkembangan teknologi, banyaknya pengguna laptop membuat persaingan memperebutkan pangsa pasar laptop di Indonesia semakin meningkat. Perusahaan membutuhkan strategi khusus untuk memenangkan persaingan. Salah satu caranya dengan meningkatkan keputusan pembelian konsumen. Penelitian ini bertujuan untuk mengetahui pengaruh harga dan kualitas produk terhadap keputusan pembelian laptop Asus (studi pada pengguna laptop Asus di Kota Semarang).Tipe penelitian ini yaitu explanatory research dengan teknik pengambilan sampel menggunakan teknik purposive sampling. Teknik pengumpulan data yang digunakan menggunakan kuesioner. Sampel pada penelitian ini berjumlah 100 pengguna laptop Asus di Kota Semarang yang pernah atau melakukan pembelian laptop Asus minimal 2 tahun terakhir. Analisis data dilakukan dengan menggunakan aplikasi SPSS 25.0 for windows terhadap uji validitas, uji reliabilitas, uji koefisien korelasi, uji koefisien determinasi, uji regresi linier sederhana dan berganda, serta uji t dan uji F. Hasil penelitian ini menunjukkan bahwa harga dan kualitas produk secara bersama-sama berpengaruh positif terhadap keputusan pembelian, dengan skor sebesar 56,994 (F Value) > 3,090 (F tabel).
Pengaruh Brand Image, Kualitas Produk dan Harga terhadap Keputusan Pembelian pada Merek Uniqlo (Studi pada Konsumen Uniqlo Dp Mall Semarang)
Authors: Kusuma Syita Salwa , Wijayanto Andi , Listyorini Sari
Published: October 2022

Indonesia is a country whose population continues to grow, with a growing middle class, and a lifestyle that tends to be consumptive and increasing awareness of using products made at home and abroad. brands that are well-known to not well-known today and have spread everywhere. Brands continue to innovate to meet the needs and desires of their consumers. Consumers have the freedom to choose the fulfilment of the style of dress with a variety of product offerings and many. So that they also get more choices of quality, price and brand image that suit their needs. This study has a purpose, namely to determine the effect of brand image, product quality and price on purchasing decisions. This type of research is an explanatory with non-probability sampling technique and sampling of 100 consumers who have bought Uniqlo at DP Mall Semarang is done online (online) by distributing questionnaires using Google Forms through social media. The analysis method uses SPSS 26 for Windows. The results showed that the brand image, product quality and price tested simultaneously had significant results and had an effect on purchasing decisions. Partially, brand image has a positive and significant influence on purchasing decisions. Product quality has a positive and significant influence on purchasing decisions. Price has a positive and significant influence on purchasing decisions.Indonesia merupakan negara yang jumlah populasimya terus bertambah, dengan jumlah kelas menengah yang terus tumbuh, serta gaya hidup yang cenderung konsumtif dan kesadaran menggunakan produk buatan dalam maupun luar negeri yang semakin meningkat. Brand pakaian yang terkenal sampai tidak terkenal pada zaman sekarang ini sudah banyak sekali dan sudah tersebar dimana-mana. Brand-brand terus berinovasi untuk memenuhi kebutuhan dan keinginan konsumennya. Konsumen memiliki leluasa dalam memilih pemenuhan gaya berpakaian dengan tawaran produk yang beragam dan banyak. Sehingga juga memperoleh lebih banyak pilihan kualitas, harga dan citra merek yang sesuai kebutuhan. Penelitian ini memiliki tujuan yakni untuk mengetahui Pengaruh brand image, kualitas produk dan harga terhadap keputusan pembelian. Tipe penelitian ini adalah tipe explanatory dengan Teknik non-probability sampling dan pengambilan sampel 100 konsumen yang pernah membeli Uniqlo di DP Mall Semarang dilakukan secara daring (online) dengan menyebarkan kuesioner menggunakan Google Form melalui media sosial. Metode analisis menggunakan SPSS 26 for Windows. Hasil penelitian menunjukkan bahwa brand image, kualitas produk dan harga diuji secara simultan memiliki hasil signifikan dan berpengaruh terhadap keputusan pembelian. Secara parsial, brand image memiliki pengaruh positif dan signifikan terhadap keputusan pembelian. Kualitas produk memiliki pengaruh positif dan signifikan terhadap keputusan pembelian. Harga memiliki pengaruh positif dan signifikan terhadap keputusan pembelian.
Pengaruh Kualitas Pelayanan dan Inovasi Layanan terhadap Kepuasan Pelanggan PT PLN (Persero) Kota Semarang
Authors: Prasetya Vanny Agung , Widayanto Widayanto , Waloejo Handojo Djoko
Published: October 2022

It is known that this century has plunged into the era of globalization. In this era of globalization, the mobility of information, investment, technology, resources, and industry is increasing. Therefore, the role of innovation will undoubtedly become more and more important. PLN is tasked with providing electricity for public purposes and the demand is increasing from year to year. The increasing demand for electricity as a result of improving the quality of people's welfare will also accompany the development of industry in Indonesia. This study uses explanatory research and the sampling technique used is non-probability sampling because the data obtained are only customer numbers and not in detail for the data. Incidental and purposive based on the criteria as a customer of PT. PLN (Persero) Semarang City, prepaid electricity, and willing to fill out the questionnaire. The data analysis technique used was quantitative analysis consisting of cross tabulation analysis, correlation coefficient test, simple and multiple regression analysis, coefficient of determination test, t test, and mediation test. The results showed that the service innovation variable had a positive and significant effect on customer satisfaction at PT PLN (Persero) Semarang.Diketahui bahwa abad ini sudah terjun ke era globalisasi. Pada abad globalisasi ini, mobilitas informasi, investasi, teknologi, sumber daya, dan industri semakin meningkat. Oleh karena itu, peran inovasi tidak diragukan lagi akan menjadi lebih penting dan lebih penting. PLN bertugas menyediakan listrik untuk kepentingan umum dan permintaannya meningkat dari tahun ke tahun. Meningkatnya kebutuhan listrik sebagai akibat dari peningkatan kualitas kesejahteraan masyarakat juga akan mengiringi perkembangan industri di Indonesia. Penelitian ini menggunakan explanatory research dan teknik pengambilan sampel yang digunakan non probality sampling karena data yang diporoleh hanya angka pelanggan saja dan tidak secara detail lagi untuk datanya. Insedental dan purposive berdasarkan kriteria sebagai pelanggan PT. PLN (Persero) Kota Semarang, listrik prabayar, dan bersedia untuk mengisi kuisioner. Teknik analisis data yang digunakan menggunakan analisis kuantitatif yang terdiri dari analisis tabulasi silang, uji koefisien korelasi, analisis regresi sederhana dan berganda, uji koefisien determinasi, uji t, dan uji mediasi. Hasil penelitian menunjukkan bahwa variabel inovasi layanan berpengaruh positif dan signifikan terhadap kepuasan pelanggan PT PLN (Persero) Semarang.
Locality and Implementation of Human Rights City
Authors: Najwah Lia Nihlah , Setiawan Arief
Published: October 2022

This article originated from studies that posed questions on the influence of Wonosobo for Human Rights Friendly City implementation in relation to religious tolerance in Buntu Village, Kejajar District. The study aims to identify the impact of the Human Rights Friendly City status that Wonosobo bears on the increasing religious tolerance in Buntu Village. Religious tolerance, which serves as one of Wonosobo's focuses on the Human Rights City agenda, becomes the limitation of this study. The time frame of this research ranges from 2016-2020, especially after the promulgation of Regional Government of Kabupaten Wonosobo Regulation Number 5 of 2016 concerning Wonosobo Regency for Human Rights Friendly City. This study uses a qualitative approach as its research method while utilizing interviews and literature studies as its data collection methods. It is worth noting that Buntu Village already possessed religious diversity and a high level of tolerance in its society even before the Human Right Friendly City policy was ratified as one of Wonosobo’s priorities. However, this study finds that tolerance in Buntu Village runs naturally without any external intervention. The Human Rights Friendly City status plays a tiny role in improving the quality of tolerance in Buntu Village. Hence, our study suggests that it is necessary for the regional government to increase the level of seriousness to continuously implement the program in the form of budget politics or other development programs.
Accessibility of Voters with Disabilities in General Elections
Authors: Fitriyah Fitriyah , Herawati Nunik Retno
Published: October 2022

Discrimination to voters with disabilities occurs recurrently although many efforts are taken to break such discrimination through regulations. This study intends to specifically describe the accessibility of voters with disabilities in the 2019 election, the obstacles, and recommendation for policy designs to improve the accessibility of voters with disabilities in elections. The simultaneous elections of 2019 which involve the legislative and presidential elections contribute to the complexity of the election, especially for the voters with disabilities. The qualitative research approach applies the analytical descriptive method. The data collection used literature studies on regulations, research results and articles related to disability. Primary data were obtained from interviews and observations (March-April 2019) in the city of Semarang. The data were also collected from documentary studies and online news searches regarding the policies/programs/activities of the General Election Commission (KPU), the General Election Supervisory Agency (Bawaslu) and organizations of disabilities, including using excerpts from their statements. The results of this study conclude that during the 2019 General Election KPU has not been able to remove social barriers to the fulfillment of the rights of disabled voters. The findings show that there is still discrimination for voters with disabilities in the 2019 elections which strengthens the findings of previous researches, although the regulatory aspect is better. The KPU policy of providing polling station (TPS) Akses at all polling stations is actually not effective in meeting their needs based on the types of disability. There are limitations on the budget and the availability to follow the topographic requirements of TPS Akses. As a recommendation, the quality of service needs to be improved by maximizing the accuracy of data for voters with disabilities, using the data as the basis for procurement and distribution of logistics and the establishment of TPS Akses, and as well as institutionalizing the synergy between KPU, local governments, and disabled community organizations/activists.
EVALUASI ALAT PERAGA KAMPANYE PEMILIHAN UMUM DI ERA DEMOKRASI ELEKTORAL
Authors: Yuliyanto Muchamad
Published: October 2022

Promotions material as an outdoor media campaign by the politicians in general election needs to be evaluated . Moreover, an election is always followed by public developments such as quality increasing of public education and knowledge as voters, ease of access to information, the critical attitude in responding to society's problems almost always become the message in the campaign promotions material.This study aims to investigate the general public's response to campaigns in the era of electoral democracy that is characterized by the usage of massive outdoor media. This research is a descriptive qualitative study with in-depth interview data collecting techniques.The results showed several things: first , there is a difference of perception between voters and candidates related campaign promotions material. Voters agreed that the presence of campaign promotions material is now a day as at too many and ruining environment’s beauty. While politicians felt that the campaign promotions materialwhich have been distributed are still lacking. Second, the informants from higher education level thought that campaign promotions material sought to enhance public awareness and knowledge of the candidates if it was used correctly . But for votersfrom lower education level, campaign promotions material is not able to increase their awareness about particular candidate , especially in the legislative elections . Third , the campaign method which considered to be most able to attract voters is politician’s activity and contributions in the community.
UJI BEDA KUALITAS PELAYANAN E-KTP DI KOTA SURAKARTA DAN KOTA SEMARANG
Authors: Sulandari Susi
Published: October 2022

Public services as the focus of the discipline of Public Administration remains interesting to observe because of the services provided by government officials to the public is still considered unsatisfactory. One of the problems of service in Indonesia is about administrative services, services e – KTP (identity cards). Surakarta and Semarang, both have been doing identity card service. Based on thr results of the initial survey in two cities, there are still many obstacles faced in the creation of identity card service.In this study, researchers will try to describe the service quality of e – KTP in Surakarta and Semarang, and will see no different whether or not the service quality of e – KTP in both cities. Type research used in this study is a quantitative study. The population of all citizens  Surakarta  and Semarang aged over 17 years and over. Becauseof the breadth of both cities used the sampling area, the city of Surakarta elected Laweyan districts and sub- districts of Semarang Pedurungan elected. Then each district taken 100 respondentsby means accidental. Analysis using interpretation of data : use of frequency distribution table predetermined number of respondents in the sample, the average sought to determine the caregories of service quality based on the resulth of the research, supplemented by interviews with respondent and the data to test the hypothesis used different test calculation of services quality in the city of Surakarta and Semarang.The result of this study concluded that the quality of service both in the district e KTPPedurungan  Semarang and Surakarta in district Laweyan results showed good all categories, but it’s god when seen in different positions of the class interval, for the districtLaweyan  Surakarta both categories at the upper limit of the interval 3,11 where as in the district Pedurungan Semarang, good bit closer to the lower limit of interval is 2,89. Based on the calculation results obtained by different test t value is equal to 3,004 with a sig 0.04. because the siq < 0,05 then it can be concluded that Ho is rejected, meaning that the average quality of service in the district Laweyan e KTP Surakarta identuty card service quality in the district of Semarang Pedurungan is not same (different). When viewed from its average of the quality of services in the district Laweyan Surakarta better than the service quality of e KTP in district Pedurungan Semarang. However, the  different is very thin.
POLA JARINGAN KOMUNIKASI MASYARAKAT MISKIN untuk PROGRAM-PROGRAM PENANGGULANGAN KEMISKINAN (ANALISIS JARINGAN KOMUNIKASI DI DUKUH TEGAL MIRING, DESA LUWEH, KABUPATEN SEMARANG)
Authors: Pradekso Tandiyo
Published: October 2022

The research mainly argues that there are communication and socialization problems in the goverment’s programs in decreasing the rate of poverty in Indonesia. Using communication network analysis, this research indicate that the communication network’s pattern’s of three poverty related programs (BLT, Raskin, and Askeskin) are centralized in nature. The centralized pattern means a lact of dyadic communications which relates to the low communication gratification for the networks members. The society disappointment and distrust to the programs is also caused by the low quality of data collection about poor households and lack of honest communication of the officers who are involved to the programs.
DECENTRALIZATION OF HOUSING POLICY FOR LOW-INCOME COMMUNITIES IN URBAN AREAS: AN ANALYSIS OF POLITICAL, FISCAL AND, ADMINISTRATIVE POLICY
Authors: Sururi Ahmad
Published: October 2022

The purpose of this study is to discuss housing decentralization policies for urban Low-Income Communities based on three decentralization issues, namely politics, fiscal, and administration, and to recommend the concept of housing decentralization as an instrument and housing policy reform.  The idea of decentralization of housing policy can’t be separated from various problems such as the debate over the authority of housing policy, the dependence of the regional government's housing budget on the central government, and various other obstacles. This study employed academic literature review related to decentralization studies and housing policies. The results of the study show that the three decentralization issues that are correlated with urban housing policies for Low-Income Communities have not yet fully provided an optimal impact on the realization of the ideal and desirable urban housing policies for Low-Income Communities. However, the very strong relationship between the three issues of decentralization and urban housing policy can be an important idea and recommendation to promote housing decentralization as an instrument and direction of urban housing policy reform for Low-Income Communities in Indonesia in the future.
FINDING THE CRAMPED SPACE IN A CITY: THE ACCESSIBILITY ASSESSMENT OF PONTIANAK CITY BASED ON THE GRIDDED POPULATION DENSITY
Authors: Gultom Bontor Jumaylinda Br , Affrilyno Affrilyno , Jati Dian Rahayu , Andi Andi
Published: October 2022

Recently, the data on population distribution only illustrates a number of density of a city or a district. Thus, it can not show the exact area of the crowded population. The population density in a city can cause a mismatch between the available space and the carrying capacity of its environment. The discrepancy can make it challenging to allocate resources or assistance in a disaster. In this regard, it is necessary to conduct research on the population's spatial distribution and the potential for movement between spatial segments. It is important to locate the cramped space where the space has high density but low accessibility in the city. This study aimed to determine the distribution of the population in the grid of 0.5 km and its assessment on accessibility in Pontianak City. The methodology used in this research is the population mapping method and space syntax. This research performs a quadrant mapping and correlation analysis to assess city accessibility. The result of the population distribution of Pontianak City shows the density concentrated in the city's center and dispersed from the river to inland. The quadrant maps show that Pontianak City has good accessibility. The quadrant map can be used as a recommendation for city development. With the quadrant division, the government can first concentrate its resources on repairing or developing the grid unit with low accessibility. With a coefficient correlation of 40.5 % and 50.9 %, this research found a positive and moderate correlation between density distribution and accessibility.
Viability of seeds of two varieties of Coffea arabica L. using different pretreatments in the tetrazolium test
Authors: BUENDÍA CONTRERAS José Duván , MORENO ROZO Laura Yolima , SALAZAR MERCADO Seir Antonio
Published: October 2022

This research attempted to determine the efficacy of the tetrazolium test in the evaluation of the seed viability of two varieties of Coffea arabica L. (‘Castillo’ and ‘Cenicafé’). The fruits were obtained from crops located in the municipalities of Salazar de las Palmas and Arboledas (Norte de Santander - Colombia). The test was carried out with embryos manually extracted from the seeds using tweezers. Three pretreatments were established: distilled water, sodium hypochlorite (2.5 %), sucrose (10 %), and a control (no pretreatment). Embryos were placed in a cysteine solution (0.5 %) to prevent oxidation, then immersed in tetrazolium solutions with concentrations of 0.035 %, 0.075 %, and 0.1 % for a period of 6, 9, and 12 hours in darkness. The results of the viability test were validated with seed germination, using the wet paper towel method in darkness. The best viability percentages were found with the application of sodium hypochlorite (NaClO 2.5 %), with a high correlation with the germination percentage. The use of pretreatments improved the efficiency of the viability test and allowed the use of low concentrations of the reagent (0.035 %), giving the farmer a quick and less expensive alternative to determine germination capacity.
Existence and Hyers–Ulam stability of solutions to a nonlinear implicit coupled system of fractional order
Authors: Zada Akbar , Ali Asfandyar , Riaz Usman
Published: October 2022

In this typescript, we study system of nonlinear implicit coupled differential equations of arbitrary (non–integer) order having nonlocal boundary conditions on closed interval [0, 1] with Caputo fractional derivative. We establish sufficient conditions for the existence, at least one and a unique solution of the proposed coupled system with the help of Krasnoselskii’s fixed point theorem and Banach contraction principle. Moreover, we scrutinize the Hyers–Ulam stability for the considered problem. We present examples to illustrate our main results.
Figurative language and persuasion in CPG sermons: The Example of a Gĩkũyũ televangelist
Authors: Njuguna Bernard G. , Schröder Helga
Published: October 2022

As a part of religious discourse, Christian sermons are a “…persuasive discourse par excellence” (Adams 2019:7). This is more pronounced in the Christian Prosperity Gospel (CPG), a system of thought and belief in which preachers

The word preacher and speaker are used interchangeably in this paper.

attempt to convince audiences to donate to their churches with the expectation that God will reward them with health and wealth. Previous research shows that the use of metaphors and metonymies pervade CPG sermons but an explanation on the mechanisms through which they persuade is rarer. With this in mind and viewing CPG sermons from their persuasive angle; this paper sets out to investigate how metaphors and metonymies are used for persuasion purposes in televised sermons presented in the Gĩkũyũ language

Gĩkũyũ is the language of the Agĩkũyũ who are largely found in central Kenya as well as in some other parts of the country. It is a Bantu language classified as a Zone E (E51) language by Guthrie (1971). According to the 2019, Population and Housing Census, the gĩkũyũ is the largest tribe in Kenya at 8,148,668 individuals. The community has dominated in televangelism but the position is changing due to the proliferation of many vernacular television stations.

. The data is drawn from authentic televised sermons. The findings indicate that metaphors and metonymies engender persuasion in sermons by affecting the perceived altruism and trustworthiness of a speaker in a sermon. This is done by means of manipulating various forms of distance suggested in the Media Proximization Approach (Kopytowska 2015, 2022). Metaphor is found to affect the axiological, epistemic, temporal and emotional distances while metonymy affects the axiological and spatial distances to activate certain pragmatic presuppositions which make them persuasive in a covert way.
Stein-Weiss inequality for local mixed radial-angular Morrey spaces
Authors: Wei Mingquan , Su Fangming , Sun Lanyin
Published: October 2022

In this article, a generalization of the well-known Stein-Weiss inequality for the fractional integral operator on functions with different integrability properties in the radial and the angular direction in local Morrey spaces is established. We find that some conditions can be relaxed for the Stein-Weiss inequality for local mixed radial-angular Morrey spaces.
Serpin family A member 1 is an oncogene in glioma and its translation is enhanced by NAD(P)H quinone dehydrogenase 1 through RNA-binding activity
Authors: Liu Wenjun , Du Min , Wan Hongping , Yang Hao , Deng Xiaorong , Chen Yu , Zhang Qian
Published: October 2022

Serpin family A member 1 (SERPINA1) is expressed abundantly in gliomas and can predict unfavorable prognosis of patients with glioma. Studies have shown that nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (NQO1) can promote the proliferation of glioblastoma multiforme cells and enhance the expression ofSERPINA1, but its effects on glioma cells remain unknown. In this study, we explored the functions ofSERPINA1in glioma tumorigenesisin vitroand then investigated whetherNQO1affects the protein expression ofSERPINA1and its mRNA level. The results showed that the translation ofSERPINA1was suppressed while its mRNA level had no significant changes under the condition ofNQO1silencing. Luciferase reporter assay and biotin pull-down assay further indicated thatNQO1bond withSERPINA13′ untranslated region. miR-1321 was also identified to targetSERPINA1, repressing its mRNA and protein levels. SERPINA1andNQO1promoted glioma cell proliferation and suppressed cell apoptosis. Moreover,SERPINA1rescued the effects of sh-NQO1 in glioma cell malignant phenotypes. In conclusion, our findings showed that oncogeneNQO1and antioncogene miR-1321 bind to oncogeneSERPINA1to affect proliferation and apoptosis of glioma cells, which can bring new solution of antitumor treatments for glioma in the future.