bluuebunny/crossref_metadata_2025 huggingface dataset:
Sharenting Syndrome: An Appropriate Use of Social Media?
Authors: Doğan Keskin Ayten , Kaytez Nazan , Damar Mustafa , Elibol Fatma , Aral Neriman
Published: May 2023

Background: The use of social media is on the rise, and posts about anything can be shared these days, whether it be clothes, jewelry, shoes, books, or food and beverages. Some parents even use their children as objects of sharing, and post about their children continuously. Parents who use social media share important moments before and after their children are born on their social network sites accounts. Sharenting refers to the practice of parents, caregivers or relatives sharing information about their children (underage) online, typically on some online platforms. This can include photos, videos, personal stories, and other updates about the child’s life. The study aimed to examine the phenomenon of sharenting syndrome in terms of its potential to cause child abuse and neglect. In addition, the aim of this study is to explore the factors associated with and predicting sharenting syndrome by evaluating it through the lens of child abuse and neglect. Methods: This study was designed with a survey model among quantitative research methods. Data were collected through social network sites with snowball sampling method. The sample consisted of people aged 18 years and over from Turkey (n = 427). Results: A total of 86.9% of the participants stated that sharing children’s photos and videos on social media platforms by parents, relatives and caregivers can be evaluated as child neglect and abuse. The variables of “gender” and “the impact of sharing on children” are factors that are associated with determining whether the sharenting syndrome is classified as abuse or not. Gender is a negative predictor of the classification of sharenting on social media as a type of child abuse and neglect. Conclusions: Since the use of social media by people is increasing, there should be measures to protect children from sharenting syndrome.
Nutritional Value of Wild and Domesticated Sanguisorba minor Scop. Plant
Authors: Ceccanti Costanza , Finimundy Tiane C. , Barros Lillian
Published: May 2023

Sanguisorba minor Scop. is a wild edible species distributed in the Mediterranean area and present in numerous traditional food recipes. In the present study, the assessment of nutritional value (ash, carbohydrates, fat, proteins, energy, free sugars, organic acids, tocopherols, fatty acid composition, and minerals) of wild and domesticated S. minor plants was performed. Results showed an increase in ash, protein, fat, organic acid, and α-tocopherol content after the plant’s domestication. Retention of free sugars, especially sucrose, was observed from wild plants to domesticated ones. However, the cultivated plants reported a higher content of polyunsaturated fatty acids than saturated molecules, and both wild collection and domestication maintained a low ω6/ω3 ratio, confirming the role of this species in the prevention of oxidative and inflammatory processes. This aspect is also suggested by the high α-tocopherol content, a vitamin known for its ability to scavenge free-radical species. Nevertheless, a high oxalic acid content was found in domesticated plants. However, the management of fertilization in open field cultivation can be robust in terms of organic acid and mineral (e.g., calcium) content. Indeed, the most representative macrominerals found in domesticated plants were Ca and Mg. The present study suggests a possible introduction of S. minor species in the human diet as a functional food or ingredient by virtue of its high nutritional properties and contents. Moreover, the management of fertilization and domestication might be a solution to maintain/enhance the nutritional profile of this wild species.
Illicit Online Pharmacies: A Scoping Review
Authors: Limbu Yam B. , Huhmann Bruce A.
Published: May 2023

This scoping review presents the extent and nature of the body of literature on illicit online pharmacies (IOPs) and identifies research gaps. Using the five-step framework developed by Arksey and O’Malley, we searched PubMed, Web of Science, EMBASE, CINAHL, Science Direct and PsycInfo to retrieve relevant studies published in English in peer-reviewed journals. The search strategy identified forty-three articles that met the inclusion criteria. Ten themes were identified and categorized into five clusters: patient risk, healthcare providers, marketing and supply chain, public health and society, and policy and regulation. Research into these clusters has evolved over time and has focused increasingly on issues related to specific drugs rather than the overall phenomenon. Data collection has been dominated by convenience sampling, online searches, content analysis and surveys. Data analysis remains primarily descriptive. Gaps within the extant literature suggest an agenda for future research into regulation and enforcement; public health awareness and education; healthcare services; risks to patients and public health; patient-, price- and product-related issues; website design; social media promotion; and supply chains and logistics. We conclude that IOPs are vastly understudied and suggest an urgent need for further empirical and conclusive research.
Emotional Responses and Support Needs of Healthcare Professionals after Adverse or Traumatic Experiences in Healthcare—Evidence from Seminars on Peer Support
Authors: Schrøder Katja , Assing Hvidt Elisabeth
Published: May 2023

The aim of this study was to identify (i) emotions experienced by healthcare professionals (HCPs) after adverse or traumatic events and (ii) needs for support after adverse or traumatic events. Data for this qualitative, descriptive study were collected at 27 seminars for 198 HCPs introducing a peer-support programme after adverse or traumatic events (The Buddy Study). Through interactive exercises, participants shared their experiences, and this study reports on the responses of an exercise identifying emotions and needs after an adverse or traumatic event. The top five emotions were anger, guilt, impotence, grief, and frustration and anxiety, and the top five needs were to be met with understanding, recognition, listening, care, and respect. Ten categories of emotions experienced by HCPs after adverse or traumatic events were constructed, and the five categories with the highest number of mentions were anger and impotence, fear and insecurity, negative self-evaluation, guilt and shame, and alone and overloaded. Nine categories relating to needs for support after adverse or traumatic events were constructed, and the five categories with the highest number of mentions were: being seen and understood, compassion, being respected, time to recover, and organisational support. The emotional disclosure promoted at the peer seminars of the Buddy Study revealed that all participants share the same emotional distress, being either second victims or potential second victims. Moreover, the support needed was of a human-to-human nature that all participants felt capable of providing as a “buddy” for a colleague. Both the identified emotions and needs for support identified in this study may contribute to qualifying the development of the content of support programmes for HCPs after traumatic or adverse events.
Impact of COVID-19 Pandemic on Daily Mobility of the Elderly Living in Small Cities in Lodz Province
Authors: Borowska-Stefańska Marta , Dulebenets Maxim A. , Kowalski Michał , Turoboś Filip , Wiśniewski Szymon
Published: May 2023

The article presents a study into the impact that the COVID-19 pandemic had on the daily mobility of those over 60 residing in small towns in the Lodz Province. The study determines the impact on the trip destination, trip frequency, preferred means of transport, distance and duration of trips, and length of the target activity. To achieve these objectives, a survey was conducted using the CATI technique (Computer Assisted Telephone Interviewing), which comprised 500 residents of small towns in the Lodz Province aged 60+, who were divided into three classes of small towns (by population size). In order to determine the impact of the COVID-19 pandemic on the daily mobility of those over 60, the tools the authors decided to use descriptive statistics and hypothesis testing. Overall, the pandemic was found to have had only a minor impact on the changes in transport behavior of those over 60 in small towns. Only 9% of respondents declared any effect on their daily mobility. The impact mainly involved a reduction in travel time and frequency, primarily among the oldest residents. Since a low level of daily mobility leads to low social activity, especially for the elderly—with a consequent sense of loneliness or even depression-towns should take measures to improve the already poor situation, one that has been further exacerbated by the pandemic.
A Systematic Review on Reporting of Methods in National Surveys about Adults’ Attitudes to Lifestyle and Environmental Risk Factors for Cancer
Authors: Faury Stéphane , Aurouet Philémon , Quintard Bruno , Foucaud Jérôme
Published: May 2023

The risks of developing cancer are significantly affected by our lifestyle and environment. While there are several uncontrollable risk factors, we can modify our lifestyle and our environment to reduce the increased threat of cancer. This systematic review aims to evaluate the methodological assessment used to evaluate attitudes about cancer risk factors among the general population. Two researchers independently screened the articles for inclusion and Critical Appraisal Skills Programme (CASP) checklists were used to assess the methodology of the included studies. Thirty-one manuscripts met the inclusion criteria with a majority of them focusing on attitudes to several cancer risk factors and six on specific cancer location risk factors. This systematic review highlights the diversity of notions used around attitudes and methods used in the method of administering the survey, as well as the format of the questions and the response scales. It is thus difficult to compare data between different countries. However, cancer is a global problem. Harmonizing methods could allow a comparison of data between countries. Recommendations to this effect are suggested.
Convolutional Neural Network-Based Deep Learning Approach for Automatic Flood Mapping Using NovaSAR-1 and Sentinel-1 Data
Authors: Andrew Ogbaje , Apan Armando , Paudyal Dev Raj , Perera Kithsiri
Published: May 2023

The accuracy of most SAR-based flood classification and segmentation derived from semi-automated algorithms is often limited due to complicated radar backscatter. However, deep learning techniques, now widely applied in image classifications, have demonstrated excellent potential for mapping complex scenes and improving flood mapping accuracy. Therefore, this study aims to compare the image classification accuracy of three convolutional neural network (CNN)-based encoder–decoders (i.e., U-Net, PSPNet and DeepLapV3) by leveraging the end-to-end ArcGIS Pro workflow. A specific objective of this method consists of labelling and training each CNN model separately on publicly available dual-polarised pre-flood data (i.e., Sentinel-1 and NovaSAR-1) based on the ResNet convolutional backbone via a transfer learning approach. The neural network results were evaluated using multiple model training trials, validation loss, training loss and confusion matrix from test datasets. During testing on the post-flood data, the results revealed that U-Net marginally outperformed the other models. In this study, the overall accuracy and F1-score reached 99% and 98% on the test data, respectively. Interestingly, the segmentation results showed less use of manual cleaning, thus encouraging the use of open-source image data for the rapid, accurate and continuous monitoring of floods using the CNN-based approach.
Polar Metabolites Profiling of Wheat Shoots (Triticum aestivum L.) under Repeated Short-Term Soil Drought and Rewatering
Authors: Szablińska-Piernik Joanna , Lahuta Lesław Bernard
Published: May 2023

The response of wheat (Triticum aestivum L.) plants to the soil drought at the metabolome level is still not fully explained. In addition, research focuses mainly on single periods of drought, and there is still a lack of data on the response of plants to short-term cyclical periods of drought. The key to this research was to find out whether wheat shoots are able to resume metabolism after the stress subsides and if the reaction to subsequent stress is the same. Gas chromatography coupled with mass spectrometry (GC-MS) is one of the most valuable and fast methods to discover changes in the primary metabolism of plants. The targeted GC-MS analyses of whole shoots of wheat plants exposed (at the juvenile stage of development) to short-term (five days) mild soil drought/rewatering cycles (until the start of shoot wilting) enabled us to identify 32 polar metabolites. The obtained results revealed an accumulation of sugars (sucrose, fructose, glucose, and 1-kestose), proline, and malic acid. During five days of recovery, shoots regained full turgor and continued to grow, and the levels of accumulated metabolites decreased. Similar changes in metabolic profiles were found during the second drought/rewatering cycle. However, the concentrations of glucose, proline, and malic acid were higher after the second drought than after the first one. Additionally, the concentration of total polar metabolites after each plant rewatering was elevated compared to control samples. Although our results confirm the participation of proline in wheat responses to drought, they also highlight the responsiveness of soluble carbohydrate metabolism to stress/recovery.
Mechanism of ADP-Inhibited ATP Hydrolysis in Single Proton-Pumping FoF1-ATP Synthase Trapped in Solution
Authors: Pérez Iván , Heitkamp Thomas , Börsch Michael
Published: May 2023

FoF1-ATP synthases in mitochondria, in chloroplasts, and in most bacteria are proton-driven membrane enzymes that supply the cells with ATP made from ADP and phosphate. Different control mechanisms exist to monitor and prevent the enzymes’ reverse chemical reaction of fast wasteful ATP hydrolysis, including mechanical or redox-based blockade of catalysis and ADP inhibition. In general, product inhibition is expected to slow down the mean catalytic turnover. Biochemical assays are ensemble measurements and cannot discriminate between a mechanism affecting all enzymes equally or individually. For example, all enzymes could work more slowly at a decreasing substrate/product ratio, or an increasing number of individual enzymes could be completely blocked. Here, we examined the effect of increasing amounts of ADP on ATP hydrolysis of single Escherichia coli FoF1-ATP synthases in liposomes. We observed the individual catalytic turnover of the enzymes one after another by monitoring the internal subunit rotation using single-molecule Förster resonance energy transfer (smFRET). Observation times of single FRET-labeled FoF1-ATP synthases in solution were extended up to several seconds using a confocal anti-Brownian electrokinetic trap (ABEL trap). By counting active versus inhibited enzymes, we revealed that ADP inhibition did not decrease the catalytic turnover of all FoF1-ATP synthases equally. Instead, increasing ADP in the ADP/ATP mixture reduced the number of remaining active enzymes that operated at similar catalytic rates for varying substrate/product ratios.
NSD Overexpression in the Fat Body Increases Antimicrobial Peptide Production by the Immune Deficiency Pathway in Drosophila
Authors: Won Chihyun , Nam Kyungju , Ko Donghee , Kang Byungjun , Lee Im-Soon
Published: May 2023

Nuclear receptor-binding SET domain-containing protein 1 (NSD1) inactivation in tumor cells contributes to an immune-cold phenotype, indicating its potential association with immune disturbances. Drosophila NSD is a homolog of the human NSD1. Thus, in this study, we investigated the effect of NSD overexpression in the fat body, the central organ involved in Drosophila immune responses. Upon ectopic expression of NSD in the fat body, the mRNA levels of antimicrobial peptides increased. Using reporter constructs containing deletions of various NF-κB sites in the Attacin-A (AttA) promoter, we found that transcriptional activation by NSD is mainly mediated via the IMD pathway by activating Relish. Since the IMD pathway is required to resist Gram-negative bacterial infections, we further examined the effect of fat body-specific NSD overexpression on Drosophila immune defenses. Upon oral ingestion of Gram-negative Pseudomonas entomophila, the survival rate of the NSD-overexpressing larvae was higher than that of the wild type, suggesting a positive role of NSD in immune responses. Taken together, these results suggest the association of NSD with the IMD pathway and is thus expected to contribute to the elucidation of the molecular mechanisms of immune malfunction in various NSD1-associated human diseases.
The Role of BDNF in Multiple Sclerosis Neuroinflammation
Authors: Nociti Viviana , Romozzi Marina
Published: May 2023

Multiple sclerosis (MS) is a chronic, inflammatory, and degenerative disease of the central nervous system (CNS). Inflammation is observed in all stages of MS, both within and around the lesions, and can have beneficial and detrimental effects on MS pathogenesis. A possible mechanism for the neuroprotective effect in MS involves the release of brain-derived neurotrophic factor (BDNF) by immune cells in peripheral blood and inflammatory lesions, as well as by microglia and astrocytes within the CNS. BDNF is a neurotrophic factor that plays a key role in neuroplasticity and neuronal survival. This review aims to analyze the current understanding of the role that inflammation plays in MS, including the factors that contribute to both beneficial and detrimental effects. Additionally, it explores the potential role of BDNF in MS, as it may modulate neuroinflammation and provide neuroprotection. By obtaining a deeper understanding of the intricate relationship between inflammation and BDNF, new therapeutic strategies for MS may be developed.
Structural Dynamics Predominantly Determine the Adaptability of Proteins to Amino Acid Deletions
Authors: Banerjee Anupam , Bahar Ivet
Published: May 2023

The insertion or deletion (indel) of amino acids has a variety of effects on protein function, ranging from disease-forming changes to gaining new functions. Despite their importance, indels have not been systematically characterized towards protein engineering or modification goals. In the present work, we focus on deletions composed of multiple contiguous amino acids (mAA-dels) and their effects on the protein (mutant) folding ability. Our analysis reveals that the mutant retains the native fold when the mAA-del obeys well-defined structural dynamics properties: localization in intrinsically flexible regions, showing low resistance to mechanical stress, and separation from allosteric signaling paths. Motivated by the possibility of distinguishing the features that underlie the adaptability of proteins to mAA-dels, and by the rapid evaluation of these features using elastic network models, we developed a positive-unlabeled learning-based classifier that can be adopted for protein design purposes. Trained on a consolidated set of features, including those reflecting the intrinsic dynamics of the regions where the mAA-dels occur, the new classifier yields a high recall of 84.3% for identifying mAA-dels that are stably tolerated by the protein. The comparative examination of the relative contribution of different features to the prediction reveals the dominant role of structural dynamics in enabling the adaptation of the mutant to mAA-del without disrupting the native fold.
Oxidative Stress Linking Obesity and Cancer: Is Obesity a ‘Radical Trigger’ to Cancer?
Authors: Jovanović Mirna , Kovačević Sanja , Brkljačić Jelena , Djordjevic Ana
Published: May 2023

Obesity is on the rise worldwide, and consequently, obesity-related non-communicable diseases are as well. Nutritional overload induces metabolic adaptations in an attempt to restore the disturbed balance, and the byproducts of the mechanisms at hand include an increased generation of reactive species. Obesity-related oxidative stress causes damage to vulnerable systems and ultimately contributes to neoplastic transformation. Dysfunctional obese adipose tissue releases cytokines and induces changes in the cell microenvironment, promoting cell survival and progression of the transformed cancer cells. Other than the increased risk of cancer development, obese cancer patients experience higher mortality rates and reduced therapy efficiency as well. The fact that obesity is considered the second leading preventable cause of cancer prioritizes the research on the mechanisms connecting obesity to cancerogenesis and finding the solutions to break the link. Oxidative stress is integral at different stages of cancer development and advancement in obese patients. Hypocaloric, balanced nutrition, and structured physical activity are some tools for relieving this burden. However, the sensitivity of simultaneously treating cancer and obesity poses a challenge. Further research on the obesity–cancer liaison would offer new perspectives on prevention programs and treatment development.
Protein Aggregates and Aggrephagy in Myopathies
Authors: Gibertini Sara , Ruggieri Alessandra , Cheli Marta , Maggi Lorenzo
Published: May 2023

A number of muscular disorders are hallmarked by the aggregation of misfolded proteins within muscle fibers. A specialized form of macroautophagy, termed aggrephagy, is designated to remove and degrade protein aggregates. This review aims to summarize what has been studied so far about the direct involvement of aggrephagy and the activation of the key players, among others, p62, NBR1, Alfy, Tollip, Optineurin, TAX1BP1 and CCT2 in muscular diseases. In the first part of the review, we describe the aggrephagy pathway with the involved proteins; then, we illustrate the muscular disorder histologically characterized by protein aggregates, highlighting the role of aggrephagy pathway abnormalities in these muscular disorders.
Recent Developments in Combination Chemotherapy for Colorectal and Breast Cancers with Topoisomerase Inhibitors
Authors: Jang Jung Yoon , Kim Donghwan , Kim Nam Deuk
Published: May 2023

DNA topoisomerases are important enzymes that stabilize DNA supercoiling and resolve entanglements. There are two main types of topoisomerases in all cells: type I, which causes single-stranded DNA breaks, and type II, which cuts double-stranded DNA. Topoisomerase activity is particularly increased in rapidly dividing cells, such as cancer cells. Topoisomerase inhibitors have been an effective chemotherapeutic option for the treatment of several cancers. In addition, combination cancer therapy with topoisomerase inhibitors may increase therapeutic efficacy and decrease resistance or side effects. Topoisomerase inhibitors are currently being used worldwide, including in the United States, and clinical trials on the combination of topoisomerase inhibitors with other drugs are currently underway. The primary objective of this review was to comprehensively analyze the current clinical landscape concerning the combined application of irinotecan, an extensively investigated type I topoisomerase inhibitor for colorectal cancer, and doxorubicin, an extensively researched type II topoisomerase inhibitor for breast cancer, while presenting a novel approach for cancer therapy.
Interaction Networks Help to Infer the Vulnerability of the Saproxylic Beetle Communities That Inhabit Tree Hollows in Mediterranean Forests
Authors: Quinto Javier , Díaz-Castelazo Cecilia , Ramírez-Hernández Alfredo , Padilla Ascensión , Sánchez-Almodóvar Esther , Galante Eduardo , Micó Estefanía
Published: May 2023

Insect communities are facing contrasting responses due to global change. However, knowledge on impacts of communities’ reorganizations is scarce. Network approaches could help to envision community changes in different environmental scenarios. Saproxylic beetles were selected to examine long-term variations in insect interaction/diversity patterns and their vulnerability to global change. We evaluated interannual differences in network patterns in the tree hollow–saproxylic beetle interaction using absolute samplings over an 11-year interval in three Mediterranean woodland types. We explored saproxylic communities’ vulnerability to microhabitat loss via simulated extinctions and by recreating threat scenarios based on decreasing microhabitat suitability. Although temporal diversity patterns varied between woodland types, network descriptors showed an interaction decline. The temporal beta-diversity of interactions depended more on interaction than on species turnover. Interaction and diversity temporal shifts promoted less specialized and more vulnerable networks, which is particularly worrisome in the riparian woodland. Network procedures evidenced that saproxylic communities are more vulnerable today than 11 years ago irrespective of whether species richness increased or decreased, and the situation could worsen in the future depending on tree hollow suitability. Network approaches were useful for predicting saproxylic communities’ vulnerability across temporal scenarios and, thus, for providing valuable information for management and conservation programs.
Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors
Authors: Ribeiro Luís Costa , Almeida Manuela , Malheiro Jorge , Silva Filipa , Nunes-Carneiro Diogo , Martins La Salete , Pedroso Sofia , Silva-Ramos Miguel
Published: May 2023

Background: Vascular calcification is an ever-more-common finding in protocoled pre-transplant imaging in living kidney donors. We intended to explore whether a connection could be found between the Agatston calcification score, prior to kidney donation, and post-donation renal function. Methods: This is a retrospective analysis of 156 living kidney donors who underwent living donor nephrectomy between January 2010 and December 2016. We quantified the total calcification score (TCaScore) by calculating the Agatston score for each vessel, abdominal aorta, common iliac, and renal arteries. Donors were placed into two different groups based on their TCaScore: <100 TCaScore group and ≥100 TCaScore group. The relationship between TCaScore, 1-year eGFR, proteinuria, and risk of 1 measurement of decreased renal function (eGFR < 60 mL/min/1.73 m2) over 5 years of follow-up was investigated. Results: The ≥100 TCaScore group consisted of 29 (19%) donors, with a median (interquartile range) calcification score of 164 (117–358). This group was significantly older, 56.7 ± 6.9 vs. 45.5 ± 10.6 (p < 0.001), had a higher average BMI (p < 0.019), and had a lower preoperative eGFR (p < 0.014). The 1-year eGFR was similarly diminished, 69.9 ± 15.7 vs. 76.3 ± 15.5 (p < 0.048), while also having an increased risk of decreased renal function during the follow-up, 22% vs. 48% (p < 0.007). Conclusions: Our study, through univariate analyses, found a relationship between a TCaScore > 100, lower 1-year eGFR, and decreased renal function in 5 years. However, a higher-than-expected vascular calcification should not be an excluding factor in donors, although they may require closer monitoring during follow-up.
Urinary and Double Incontinence in Cognitively Impaired Patients: Impacts on Those Affected and Their Professional Caregivers
Authors: Jaekel Anke Kirsten , Rings Theresa Maria , Schmitz Franziska , Knappe Franziska , Tschirhart Alix , Winterhagen Franziska Isabelle , Kirschner-Hermanns Ruth Klara Maria , Knüpfer Stephanie C.
Published: May 2023

Urinary or double incontinence in frail elderly people is common and leads to a reduction in quality of life and an increased burden on the patients’ caregivers. Up to now, no special instrument has been available to assess the impact of incontinence on cognitively impaired patients and their professional caregivers. Thus, the outcomes of incontinence-specific medical and nursing interventions for cognitively impaired individuals are not measurable. Our aim was to investigate the impacts of urinary and double incontinence on both the affected patients and their caregivers using the newly developed “International Consultation on Incontinence Questionnaire Cognitively Impaired Elderly” (ICIQ-Cog) tool. The severity of incontinence was measured by incontinence episodes per night/per 24 h, the type of incontinence, the type of incontinence devices used, and the proportion of incontinence care out of total care; all these measures were correlated to the ICIQ-Cog. Incontinence episodes per night and the proportion of incontinence care out of total care showed significant correlations with the patient- and caregiver-related ICIQ-Cog scores. Both items have negative effects on patient quality of life and caregiver burden. Improving nocturnal incontinence and reducing the need for incontinence care overall can decrease the incontinence-specific bother of affected patients and their professional caregivers. The ICIQ-Cog can be used to verify the impacts of medical and nursing interventions.
Getting It Right in Restrictive Lung Disease
Authors: Carlucci Annalisa , Fusar Poli Barbara
Published: May 2023

Restrictive lung disease (predominantly in patients with neuromuscular disease (NMD) and ribcage deformity) may induce chronic hypercapnic respiratory failure, which represents an absolute indication to start home NIV (HNIV). However, in the early phases of NMD, patients may present only diurnal symptoms or orthopnoea and sleep disturbances with normal diurnal gas exchange. The evaluation of respiratory function decline may predict the presence of sleep disturbances (SD) and nocturnal hypoventilation that can be respectively diagnosed with polygraphy and PCO2 transcutaneous monitoring. If nocturnal hypoventilation and/or apnoea/hypopnea syndrome are detected, HNIV should be introduced. Once HNIV has been started, adequate follow-up is mandatory. The ventilator’s built-in software provides important information about patient adherence and eventual leaks to correct. Detailed data about pressure and flow curves may suggest the presence of upper airway obstruction (UAO) during NIV that may occur with or without decrease in respiratory drive. Etiology and treatment of these two different forms of UAO are different. For this reason, in some circumstances, it might be useful to perform a polygraph. PtCO2 monitoring, together with pulse-oximetry, seem to be very important tools to optimize HNIV. The role of HNIV in neuromuscular disease is to correct diurnal and nocturnal hypoventilation with the consequence of improving quality of life, symptoms, and survival.
Self-Assembling Peptide RADA16 Nanofiber Scaffold Hydrogel-Wrapped Concentrated Growth Factors in Osteogenesis of MC3T3
Authors: Yang Renjie , Chen Jiali , Wang Dingjie , Xu Yichen , Ou Guomin
Published: May 2023

Concentrated growth factors (CGFs) are widely used in surgery with bone grafting, but the release of growth factors from CGFs is rapid. RADA16, a self-assembling peptide, can form a scaffold that is similar to the extracellular matrix. Based on the properties of RADA16 and CGF, we hypothesized that the RADA16 nanofiber scaffold hydrogel could enhance the function of CGFs and that the RADA16 nanofiber scaffold hydrogel-wrapped CGFs (RADA16-CGFs) would perform a good osteoinductive function. This study aimed to investigate the osteoinductive function of RADA16-CGFs. Scanning electron microscopy, rheometry, and ELISA were performed, and MC3T3-E1 cells were used to test cell adhesion, cytotoxicity, and mineralization after administration with RADA16-CGFs. We found that RADA16 endowed with the sustained release of growth factors from CGFs, which can help maximize the function of CGFs in osteoinduction. The application of the atoxic RADA16 nanofiber scaffold hydrogel with CGFs can be a new therapeutic strategy for the treatment of alveolar bone loss and other problems that require bone regeneration.
A Data-Based Tool Failure Prevention Approach in Progressive Die Stamping
Authors: Farioli Daniele , Kaya Ertuğrul , Fumagalli Andrea , Cattaneo Paolo , Strano Matteo
Published: May 2023

The research on methods for monitoring sheet metal stamping is benefiting from the increased availability of enabling technologies such as sensors, data mining software, cloud computing, and artificial intelligence. The predictive maintenance policies of tools (punches and dies) can be targeted at monitoring progressive wear or at the detection of sudden failures or anomalies. Early detection of tool failure is the method preferred by the recent literature on data management in sheet metal stamping. However, the stamping of small parts poses challenges due to multiple tools and signals and limited visibility of die wear, requiring management of multiple sensors and data sources. This paper proposes a failure prevention approach for progressive die stamping using global and local force sensors with upper bounds for maximum values to indicate unhealthy conditions. The methodology was tested on millions of small washers made of carbon steel. The stamping process was implemented using a servo-press with a high rate. The press was equipped with eight in-process sensors, including strain gauges, thin foil force sensors, and acoustic sensors. The data of material properties, maintenance reports, statistical process control data, and in-process sensors were collected and stored in a data lake. By combining the in-process sensor acquisition with the corresponding log events and maintenance data in the same time span, it is possible to look for correlations among the variables and build an effective tool health prevention policy.
Influence of Novel Beam Shapes on Laser-Based Processing of High-Strength Aluminium Alloys on the Basis of EN AW-5083 Single Weld Tracks
Authors: Nahr Florian , Bartels Dominic , Rothfelder Richard , Schmidt Michael
Published: May 2023

The commonly used Gaussian intensity distribution during the laser-based processing of metals can negatively affect melt pool stability, which might lead to defects such as porosity, hot cracking, or poor surface quality. Hot cracking is a major factor in limiting production rates of high-strength aluminium alloys in laser-based processes such as welding or the powder bed fusion of metals (PBF-LB/M). Going away from a Gaussian intensity distribution to ring-shaped profiles allows for a more even heat distribution during processing, resulting in more stable melt pools and reduced defect formations. Therefore, the aim of this study is to investigate the influence of different laser beam profiles on the processing of high-strength aluminium alloys by using a multicore fiber laser, allowing for in-house beam shaping. Single weld tracks on the aluminium alloy EN AW-5083 are produced with varying laser powers and weld speeds, as well as different beam profiles, ranging from Gaussian intensity distribution to point/ring profiles. The molten cross sections are analyzed regarding their geometry and defects, and the surface roughness of the weld tracks is measured. By using point/ring beam profiles, the processing window can be significantly increased. Hot cracking is considerably reduced for weld speeds of up to 1000 mm/s compared to the Gaussian beam profile. Furthermore, the melt pool width and depth are more stable, with varying parameters for the point/ring profiles, while the Gaussian beam tends to keyhole formation at higher beam powers. Finally, a strong decrease in surface roughness for the point/ring profiles, accompanied by a significantly reduced humping effect, starting even at lower beam powers of 200 W, can be observed. Therefore, these results show the potential of beam shaping for further applications in laser-based processing of high-strength aluminium alloys.
Mechanism Analysis of the Strong Coastal Current Zone and Abrupt Strong–Current Phenomena in Spring and Summer in the Yangjiang Sea Area of Western Guangdong in the Northwest of the South China Sea
Authors: Chen Yizhan , Cao Yonggang , Feng Yanqing , Ma Yuan , Luo Shihao , Wang Weiping , Ouyang Yongzhong , Liu Yuqiang , Liu Changjian , Liao Shizhi , Xiao Zhijian
Published: May 2023

Residual current analysis of multiple stations’ periodic observational data for sea currents, and multiple voyages, multiple seasons from 2018 to 2022, revealed the existence of a strong southwest current zone, 20–30 m underwater and within the coastal current area of Yangjiang, western Guangdong, in the northwest region of the South China Sea. The velocity of the residual currents in the strong–current zone was 38.2–100.3 cm/s. Observational data for wind, sea currents, salinity and tide from multiple coastal stations in the spring (from March 2019 to May 2019) and summer (from June 2019 to August 2019) of 2019 demonstrated the existence of abrupt strong currents in the coastal current sea area of Yangjiang, western Guangdong. Analyses of continuous sequence hydro meteorological data for the Yangjiang area indicated that wind stress was the main factor determining the direction of sea currents; increases in the near-shore water level produce a westward geostrophic current and a wind current in the shallow sea area; their joint effect was the key factor determining the velocity of the coastal current in this sea area. In spring and summer, when Pearl River runoff into the sea reaches a peak, and under the action of the northeast wind, the water level on the west coast of Guangdong rose. This created a barotropic pressure–gradient force from the shore to the outer sea, generating a southwestward geostrophic current in the same direction as the wind-driven current. The joint action of the wind-driven and geostrophic currents then generated a sudden southwestward coastal current.
Multi-Body Dynamics Modeling and Straight-Line Travel Simulation of a Four-Tracked Deep-Sea Mining Vehicle on Flat Ground
Authors: Xia Maozhen , Lu Haining , Yang Jianmin , Sun Pengfei
Published: May 2023

Deep-sea mining vehicles (DSMVs) are highly prone to sinking and slippage when traveling on extremely soft seafloor sediments. In addition, DSMVs can be vulnerable to dangerous situations such as overturning due to the non-homogeneous characteristic of the seafloor sediments, the heavy loads carried by DSMVs, and the complex and varied topography of the seafloor. When the terrain is uneven, four-tracked DSMVs can show excellent traveling abilities and safety performances compared with conventional dual-tracked vehicles, thus having a broad range of applications. Consequently, modeling and simulation of a four-tracked DSMV are essential for the study of DSMV traveling performance. To enhance adaptability to uneven terrain, the tracks are designed to be rotatable. First, a multi-body dynamics model is built in the Recurdyn software based on the actual structural properties of a specially designed four-tracked DSMV prototype. Then, the model’s forces are modified to reflect the actual circumstances of seafloor travel. Applying a more accurate shear model, a user subroutine is written to modify the track–soil force. Moreover, internal resistance and water resistance are considered and applied to the model in the form of external loads. Then, based on the multi-pass effect, the track–soil force to the rear track is modified. Moreover, considering the relationship between soil forces and velocity, a velocity coefficient is summarized and added to the resistance estimation equation. Consequently, a more realistic dynamic model of the mining vehicle has been developed. On this basis, simulations of straight-line travel on flat ground are performed. In addition, to investigate the effects of rotatable tracks, a straight-line travel simulation with tracks fixed is also performed. By analyzing the simulation results, the motion features and dynamic characteristics of a four-tracked DSMV with rotatable tracks when traveling in a straight line on flat ground can be studied.
Ria de Alvor Suitability for Aquaculture: Future Challenges
Authors: Picado Ana , Pereira Humberto , Sousa Magda C. , Dias João Miguel
Published: May 2023

A large number of estuarine systems provide favorable conditions for aquaculture, including high nutrient content, sheltered waters, and favorable water temperatures. In this context, the main objective of this work is to identify the most suitable areas within the Ria de Alvor for bivalve and fish aquaculture production considering present and future conditions in a climate change context. A suitability index was developed based on the results of an annual simulation with the Delft3D model and the thresholds and optimal values of development of each species were analyzed. Generally, results suggest that the most suitable areas for aquaculture were located along the axis of the lagoon’s main channel, although seasonal variability was presented depending on the species. During winter and autumn, bivalves (oysters and mussels) are more susceptible to environmental conditions than fish. Conversely, spring presents the most favorable environmental conditions for the production of all species considered. Future projections indicate a general decrease in aquaculture suitability, particularly during winter for both bivalve species and during summer for Mussels, mostly due to the predicted increase in water temperature.
Numerical Simulation of the Interaction between Solitary Waves and Underwater Barriers Using a VPM–THINC/QQ-Coupled Model
Authors: Li Mengyu , Zhao Xizeng , Yin Mingjian , Zong Yiyang , Lu Jinyou , Yao Shiming , Qu Geng , Luan Hualong
Published: May 2023

The interaction between solitary waves and underwater barriers is investigated using our in-house code, entitled VPM (volume-average/point-value multi-moment)–THINC/QQ (THINC method with quadratic surface representation and Gaussian quadrature)-coupled model. The stability and accuracy of the proposed model are validated by comparing the numerical results with those of the well established two-phase flow solver interFoam. All the results indicate that the presented coupled model has the advantage of high fidelity in simulating solitary wave propagation. Subsequently, solitary waves passing over a single underwater barrier are simulated by the present model. Numerical results are compared with experimental results in terms of the free surface elevation, velocity profile, vorticity field, and wave forces. Great agreements are obtained. In the end, the interactions between solitary waves and double underwater barriers are investigated numerically. The results reveal that the reflection coefficient increases first, and then decreases, with the increasing space between the two barriers. For cases with different wave heights, the transmission coefficient decreases monotonically, and the dissipation coefficient is opposed to the transmission coefficient.
Removal of Methylene Blue from Aqueous Solutions by Surface Modified Talc
Authors: Chen Shuyang , Zhang Mei , Chen Hanjie , Fang Ying
Published: May 2023

In this study, raw talc powder surface modification was conducted, and the powder was modified in two different methods using acid washing and ball milling. Modified talc was characterized by X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). In order to investigate the adsorption capacity of modified talc on dyes, adsorption experiments were carried out with methylene blue (MB) in aqueous solutions as the target contaminant. The findings of the characterization revealed that both modifications increased the adsorption capacity of talc, which was attributed to changes in specific surface area and active groups. The influence of process parameters such as contact time, pH, dye concentration, and adsorbent dosage on the adsorption performance was systematically investigated. Modified talc was able to adsorb MB rapidly, reaching equilibrium within 60 min. Additionally, the adsorption performance was improved as the pH of the dye solution increased. The isotherms for MB adsorption by modified talc fitted well with the Langmuir model. The pseudo-second-order model in the adsorption kinetic model properly described the adsorption behavior. The results show that the modified talc can be used as an inexpensive and abundant candidate material for the adsorption of dyes in industrial wastewater.
Effect of Mg/Si Ratio on the Bendability and Anisotropic Bend Behavior of Extruded 6000-Series Al Alloy
Authors: Zhang Qi , Xu Xiaochang , Wang Yu
Published: May 2023

Extruded Al-Mg-Si profiles applied in the automotive industry are required to achieve an appropriate combination of strength and bendability. In order to investigate the effect of Mg/Si ratio on the bendability and anisotropic bending behavior, AA6005 and AA6061C were extruded to 2 mm thick plates. More Goss texture and anisotropic particle clusters exist in AA6005 alloys with a low Mg/Si ratio, which leads to a high tendency of surface roughing and cracking and to strong anisotropy in their bendability. However, more low-angle grain boundaries, cubic texture and comparatively random distribution of particles exists in AA6061C alloys with a high Mg/Si ratio, which blunts the surface roughing and crack process. The surface undulation is the outcome of the strain-intense localization of several layers of grains in the vicinity of the outer elongated surface. The strain localization and surface undulation lead to shear band initiation near the valleys. Several cooperating micro-mechanisms in AA6005, including grain clusters with Goss and Cubic orientation, heterogeneously nucleated particles and grain boundary spatial arrangements, lead to the grain boundary decohesion along a shear direction. AA6005 shows for predominately intergranular fractures in nature, with some areas exhibiting grain boundary decohesion during bending in the TD. However, AA6061C shows a predominately transgranular in nature, with some areas exhibiting intergranular fracture, which is affected by shear band development.