bluuebunny/crossref_metadata_2025 huggingface dataset:
Is There Any Role for Bach Flowers, Lavender Oil and Hypericum in Psychiatry?
Authors: Marazziti Donatella , Gurrieri Riccardo , Crivelli Nicola Schulz Bizzozzero , Arone Alessandro
Published: January 2025

Introduction/Objective:

Alternative medicine is a term encompassing several approaches
proposed for their healing effects instead of conventional medicine. The present narrative review
aimed at exploring the possible use of some popular alternative treatments to manage anxiety and
depression, with a specific focus on Bach flowers, lavender oil, and Hypericum which are among the
most popular alternative remedies in Italy.

Methods:

A thorough search was conducted across electronic databases, such as PubMed, Google
Scholar, and PsycINFO for English-written papers published in peer-reviewed journals, available in
full-text or abstract. The primary keywords included “Alternative medicine”, “Anxiety”, “Depression”,
“Bach Flowers”, “Lavender Oil”, and “Hypericum”. Studies were included if they met the
following criteria: focus on the Bach flowers, lavender oil, or hypericum, in the treatment or management
of anxiety and depression.

Results:

The scientific evidence supporting the benefits of Bach flowers for anxiety and depression
is still inconclusive, with some studies suggesting potential benefits in reducing anxiety symptoms
and other showing no significant effects. Lavender oil has been explored for its potential therapeutic
effects on anxiety and depression, but even in this case the overall findings remain controversial due
to methodological limitations. St. John’s Wort (or Hypericum) showed some effect in mild to moderate
depression, with efficacy comparable to standard antidepressants and fewer side effects, although
its use requires careful cautions when prescribed with other drugs.

Conclusion:

The overall findings of the present review would indicate that the scientific evidence
about the possible usefulness of Bach flowers, lavender oil, and Hypericum is limited. If the effectiveness
of Bach flowers is controversial, some potential benefits of lavender oil and Hypericum
have been reported, however they need to be replicated and deepened in controlled clinical studies.
RSSI Enabled Routing in Fiber Wireless Access Network
Authors: Solanki Sangita , Upadhyay Raksha , Bhatt Uma Rathore , Bhat Vijay
Published: January 2025

Introduction:

There are various concerns in Fiber wireless access networks, such as
ONU placement, survivability, network planning and its cost, architectural developments, etc.
In this paper, we have focused on front end survivability of the network, which mainly depends on
the routing algorithms employed at the front end of the network.

Method:

The effectiveness of the proposed scheme lies in finding the next alternate path in case of
link/component failure with minimum delay. Hence, delay is the appropriate parameter to evaluate
the efficacy of the proposed technique. In this paper, RSSI-based routing (RBRA) is proposed for
various cases of link failures. Delay performance for each of the cases has been compared with two
previous approaches maximum protection minimum link cost (MPMLC) and minimum hop
routing algorithm (MHRA).

Result:

It is found that RBRA performs better than MPMLC and MHRA. For single link failure
and two source destination pairs in the network with 50 wireless routers delay decreases by 58 % and 37 % in RBRA as compared to MHRA and MPMLC, respectively.

Conclusion:

Hence, these algorithms can be integrated with RSSI-based route selection. This could
be an attractive future direction for research.
Új szemlélet az időskori, többrészes, elmozdult proximalis humerustörések szögstabil lemezes kezelésében
Authors: Burkus Máté , Bruch Andreas , Bergmann Eva Maria , József Kristóf , Karahodzic-Franjic Munira , Zdichavsky Marty
Published: January 2025

A proximalis humerust érintő törések megjelenése emelkedő tendenciát mutat, különösen a már idősödő, ezáltal jellemzően osteoporosissal rendelkező populációnál. Az egyszerű, vagy érdemi elmozdulás nélküli esetek konzervatívan is jól kezelhetők, azonban a többrészes, illetve elmozdult törések ellátása kihívást jelent. Az osteosynthesisek során a szögstabil lemezelés preferált eljárás, azonban a komplikációk előfordulása nem ritka. Intézetünkben 2019 óta van rutinszerű alkalmazásban az osteoporotikus multifragmentalis proximalis humerus törések ellátásában a valgizáló helyzetű szögstabil lemezelési módszer. Jelen vizsgálatunk során 37, 70 év feletti páciens (31 nő és 6 férfi), életkor 78,4±6,4 év, rövidtávú klinikai és radiológiai eredményeit értékeltük, retrospektív módon. Az utánkövetési idő 14,5±5,3 hónap volt, mely során a váll funkcióját Constant-Murley Score-al vizsgálva 18 páciensnél kitűnő, 10-nél jó, 6 esetnél kielégítő, még 3 esetben gyenge funkcionális eredményt tapasztaltunk, átlagban 81,8±11,0 értékkel. A funkcionális eredmények az életkortól, a törés jellegétől, a BMI-től, illetve a páciensek ismert alapbetegségeitől függetlennek mutatkoztak. Vizsgálatunk során az összesített komplikációs rátát 10,8%-nak, a revíziós rátát 5,4%-nak találtuk. Tapasztalataink szerint a valgizáló helyzetű szögstabil osteosynthesis a proximalis humerus törések kezelése során az optimalizált fej-, illetve lemezhelyzet miatt kiemelkedő funkcionális eredményeket biztosít alacsony szövődményráta mellett. A módszer kifejezetten jól alkalmazható a gyengült csontszerkezet melletti, elmozdult, többrészes törések esetén.
A könyökízületi interpositiós arthroplastica alkalmazási lehetőségei
Authors: Cele Krisztián , Farkasházi Miklós , Gunther Tibor
Published: January 2025

A könyökízületi interpositiós arthroplastica metodikájának fejlődése az 1900-as évek elején vettekezdetét. A technika és eszközök fejlődésével a század végéhez közeledve a protézis implantáció alternatívájává nőtte ki magát. A műtét főként rheumatiod arhtritisben szenvedő betegeknél, illetve poszttraumás esetekben alkalmazható. Az eljárás lényege, hogy a könyökízületet feltárva, synovectomia és debridement után interpositiós graftot rögzítünk az ízületi felszínek közé. Kezdetben reszekciót követően alkalmaztak interpositiót, amely nagyfokú instabilitást eredményezett, így manapság reszekciót nem végzünk. A történelem során számos grafttal próbálkoztak az eljárás tökéletesítése céljából: fascia, sertés húgyhólyag, sertés és emberi bőr, szarvasmarha kollagén membrán, dura mater. Korunkban a műtét célja a beteg fájdalmának csökkentése, életminőségének javítása a funkció helyreállításával, instabilitás nélkül. Azalábbiakban a szerzők ismertetik tapasztalatukat a fenti műtéti technika kivitelezésében, két rheumatiodarthritises és egy poszttraumás eset tükrében.
¿Cuánto sabe la inteligencia artificial sobre derecho colombiano?
Authors: Arévalo-Robles Gabriel Andrés , Castellanos-Cortés Omaira
Published: January 2025

Este articulo evalúa la capacidad de tres modelos de lenguaje de gran tamaño (LLM) —ChatGPT 3.5, ChatGPT 4 y Gemini Pro— para responder consultas legales en el contexto colombiano. A través de un análisis exhaustivo de respuestas a preguntas en cinco áreas del derecho, se encontró que, si bien ChatGPT 4 obtuvo los mejores resultados generales, ninguno de los modelos logró alcanzar un nivel de precisión aceptable para su aplicación práctica en el ámbito jurídico. Los resultados sugieren que, aunque los LLM ofrecen un gran potencial para automatizar tareas legales, su uso en la práctica requiere de una supervisión humana rigurosa y de un desarrollo continuo de los modelos. Este estudio contribuye al debate sobre la ética y las implicaciones legales de la inteligencia artificial en el ámbito jurídico, destacando la necesidad de establecer marcos regulatorios adecuados para garantizar un uso responsable de estas tecnologías.
El rol de los militares en la gestión de las emergencias
Authors: Expósito Enriqueta
Published: January 2025

En el campo de la protección civil siempre ha existido la posibilidad de actuación militar en colaboración y apoyo de los agentes civiles. En España, la creación de la Unidad Militar de Emergencias, a mediados de la primera década de los 2000, supuso un salto cualitativo porque a través de esta unidad especializada, de naturaleza militar, que actúa bajo sus mandos naturales, se vehicula desde entonces todo el apoyo de las Fuerzas Armadas en la gestión de las emergencias civiles. Este artículo expone la evolución de esta intervención en España y su sustento normativo. Lejos de implicar una militarización de este campo, se identifica que esta intervención se concibe como auxiliar: actúa bajo las órdenes del Gobierno, siempre que sea requerida expresamente, cuando los recursos y medios existentes en el ámbito civil no sean adecuados o suficientes.
La Fuerza Armada de El Salvador y su tradicional versatilidad en emergencias
Authors: Molina-Gabriel Rafael Antonio
Published: January 2025

Desde los Acuerdos de Paz de El Salvador, en 1992, la militarización discursiva ha sido usada para justificar la intervención de los militares en áreas de la seguridad pública que no pertenecen a su rol principal. Así se ha justificado su uso, paulatinamente normalizado, para el desarrollo de misiones ajenas a la defensa, entre ellas las emergencias civiles, convirtiéndose en una administración comodín o “hacelotodo”. Este artículo, a través de un método analítico-deductivo, busca analizar las leyes que habilitan el uso de la Fuerza Armada de El Salvador en emergencias, su rol y las misiones que ha ejecutado, así como sus capacidades para afrontarlas. Se demuestra que su uso en emergencias es un indicador de la militarización discursiva de la Fuerza Armada, a pesar de que los avances normativos al respecto han intentado contener este fenómeno.
Analisis Rekomendasi Pemilihan Mi Instan Berdasarkan Logika Fuzzy Mamdani
Authors: Al-Jabbar Muhammad
Published: January 2025

Mi instan adalah salah satu produk makanan cepat saji saat ini banyak dikonsumsi oleh masyarakat. Memilih mi instan untuk konsumen yang mengonsumsinya tentu tidak mudah. Banyak produk mi instan yang beredar di pasaran baik secara pasar tradisional maupun modern pasar. Biasanya konsumen akan memilih mi instan sesuai dengan keinginannya, baik dari kandungan nutrisi, harga, dan sebagainya. Konsumsi mi instan dengan kandungan nutrisi yang rendah akan kurang baik untuk kesehatan. Selain itu juga, konsumen mempertimbangkan harga mi instan agar menghemat biaya hidup. Maka dari itu, perlu adanya pemilihan makanan mi instan yang baik dikonsumsi dengan harga yang terjangkau. Penelitian ini bertujuan untuk memilih produk makanan mi instan dengan faktor kandungan nutrisi dan harga menggunakan Aplikasi Logika Fuzzy. Metode Logika Fuzzy mempunyai tiga tahapan proses yaitu fuzzifikasi, inferensi dan defuzzifikasi. Metode yang digunakan adalah metode mamdani dengan bantuan program fuzzy logic designer pada Matlab R2023b. Metode logika fuzzy Mamdani dapat digunakan untuk menentukan tingkat keakurasian untuk memilih makanan mi instan yang direkomendasikan. Hasil dari penelitian ini adalah mi instan sampel ke-2 yang menjadi mi instan direkomendasikan kepada masyarakat karena memiliki nutrisi tinggi dan harga yang terjangkau.
Applications of K-Means Analysis in Indonesian Labor in 2023
Authors: Diah Sukowati  , Zahra Fadhila Fathin , Isna Jamilatun Solekhah  , Nur Laily Marik , Thania Putri Aida
Published: January 2025

Penelitian ini memiliki signifikansi penting dalam mengeksplorasi kondisi ketenagakerjaan di Indonesia dengan menerapkan analisis K-Means untuk pengelompokan provinsi berdasarkan kualitas tenaga kerja. Tujuan dari penelitian ini adalah memberikan pemahaman mendalam tentang kondisi ketenagakerjaan di Indonesia melalui pengelompokan provinsi berdasarkan kualitas tenaga kerja. Data sekunder diperoleh dari Badan Pusat Statistik dan mencakup variabel kunci seperti Tingkat Pengangguran Terbuka (X1), Tingkat Partisipasi Angkatan Kerja (X2), Pekerjaan Formal (X3), Tingkat Kerja Paruh Waktu (X4), dan Persentase Tenaga Kerja Berpendidikan Rendah (X5). Analisis statistik deskriptif mengungkap variasi signifikan dalam kondisi ketenagakerjaan di antara provinsi, memberikan dasar penting untuk pengelompokan lebih lanjut. Proses pengelompokan menggunakan metode K-Means menghasilkan tiga kelompok, memungkinkan pemeriksaan lebih mendalam terhadap karakteristik tenaga kerja di tingkat provinsi. Evaluasi jumlah optimal kelompok menggunakan silhouette mengkonfirmasi bahwa tiga kelompok mencerminkan kondisi paling relevan. Kelompok pertama menandai provinsi dengan profil pekerja yang stabil dan beragam, menunjukkan tingkat pengangguran rendah dan partisipasi angkatan kerja yang seimbang. Sementara itu, kelompok kedua menggambarkan pasar tenaga kerja yang dinamis dengan partisipasi tinggi dan perubahan signifikan dalam struktur pekerjaan. Namun, kelompok ketiga menghadapi tantangan di pasar kerja dengan tingkat pengangguran yang tinggi. Hasil analisis ini memberikan pemahaman yang lebih dalam tentang disparitas ketenagakerjaan di Indonesia, memungkinkan formulasi rekomendasi kebijakan yang lebih fokus dan responsif yang disesuaikan dengan kebutuhan masing-masing provinsi.
Faktor-faktor Sosial Ekonomi yang Berpengaruh terhadap Skor Matematika PISA Indonesia Tahun 2022 Pasca Pandemi Covid-19
Authors: Rahma Budiasti  , Luluk Fitriyani  , Zulfa Nahdiana
Published: January 2025

Pandemi Covid-19 yang terjadi beberapa tahun yang lalu memengaruhi berbagai aspek kehidupan manusia. Salah satu akibatnya adalah penurunan kualitas pendidikan yang terlihat dari skor tes hasil PISA tahun 2022 Indonesia yang menurun dibandingkan tahun 2018 khususnya skor matematika. Penurunan kualitas ini dikarenakan pembelajaran di masa pandemi dilakukan secara daring yang memaksa siswa untuk mempunyai berbagai fasilitas. Sedangkan tidak semua siswa beruntung mendapatkan fasilitas yang memadai. Kepemilikan berbagai fasilitas untuk menunjang pendidikan tergantung pada tingkat kesejahteraan sosio-ekonomi keluarga siswa. Padahal, keadaan sosio-ekonomi juga cukup sulit di masa pandemi. Oleh karena itu, penelitian ini dilakukan untuk mengetahui faktor-faktor sosio-ekonomi mana yang berpengaruh terhadap skor matematika PISA 2022. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh baik positif maupun negatif antara kondisi sosio ekonomi terhadap skor matematika dengan level kuat, lemah, dan sangat lemah.
Penerapan Metode K-Means Clustering dalam Pengelompokan Provinsi-Provinsi di Indonesia Berdasarkan Produktivitas Tanaman Pangan
Authors: Olivya angellina  , Asma’ Khoirunnisa'  , Yunita Putri Utami
Published: January 2025

Produktivitas bahan pangan menjadi tolak ukur yang krusial dalam menentukan kesejahteraan dan ketahanan pangan suatu bangsa. Oleh sebab itu penelitian ini bertujuan untuk melihat bagaimana pengelompokkan provinsi di Indonesia berdasarkan produktivitas bahan pangan.  Data yang digunakan dalam penelitian ini adalah data sekunder yang bersumber dari Badan Pusat Statistik yang berisikan produktivitas bahan pangan di Indonesia berdasarkan 34 provinsi pada tahun 2015. Ada tujuh variabel yang akan digunakan dalam penelitian ini yaitu produktivitas padi, produktivitas jagung, produktivitas kedelai, produktivitas kacang tanah, produktivitas kacang hijau, produktivitas ubi kayu dan produktivitas ubi jalar. Untuk melakukan pengelompokan, dengan bantuan program RStudio digunakan analisis K-Means clustering, dimana analisis ini dapat mengelompokkan objek-objek yang melibatkan pengiraan yang efisien dan tidak memerlukan banyak parameter. Dari hasil penelitian diperoleh dua cluster, yakni cluster 1 untuk provinsi dengan produktivitas bahan pangan tinggi dan cluster 2 untuk provinsi dengan produktivitas bahan pangan rendah. Cluster 1 terdiri dari 20 provinsi, sedangkan cluster 2 terdiri dari 14 provinsi antara lain Provinsi Riau, Kepulauan Bangka Belitung, Kepulauan Riau, DKI Jakarta, Bali, Nusa Tenggara Timur, Kalimantan Barat, Kalimantan Tengah, Kalimantan Utara, Sulawesi Utara, Sulawesi Tenggara, Maluku Utara, Papua Barat, dan Papua.
Pemodelan Tingkat Pengangguran Terbuka di Provinsi Kepulauan Riau Menggunakan Regresi Data Panel
Authors: Armiyana Widya , Sri Subanti  , Isnandar Slamet
Published: January 2025

Tingkat Pengangguran Terbuka (TPT) merupakan salah satu indikator yang digunakan untuk mengukur kesejahteraan sosial masyarakat. Berdasarkan data BPS pada tahun 2022, Provinsi Kepulauan Riau berada di peringkat kedua provinsi dengan TPT tertinggi di Indonesia, yakni sebesar 8,09 persen. Tingkat pengangguran yang tinggi dapat mengakibatkan pembangunan ekonomi menjadi terhambat. Oleh karena itu, perlu dilakukan analisis lebih lanjut mengenai faktor-faktor yang memengaruhi TPT di Provinsi Kepulauan Riau. Penelitian ini akan menggunakan metode regresi data panel yang menggabungkan data cross section dan time series dalam memodelkan TPT. Terdapat empat faktor yang diduga berpengaruh terhadap TPT di Provinsi Kepulauan Riau, yaitu laju pertumbuhan produk domestik regional bruto (PDRB), tingkat partisipasi angkatan kerja (TPAK), upah minimum kabupaten/kota (UMK), dan rata-rata lama sekolah (RLS). Hasil penelitian menunjukkah bahwa model terbaik yaitu Fixed Effect Model (FEM). Selain itu, variabel laju pertumbuhan PDRB, tingkat partisipasi angkatan kerja, dan rata-rata lama sekolah berpengaruh secara signifikan terhadap TPT di Provinsi Kepulauan Riau dengan nilai koefisien determinasi sebesar 78,93 persen.
Pelabelan Berbasis Jarak Pada Beberapa Kelas Graf
Authors: Komarullah Hafif
Published: January 2025

Teori graf terus berkembang sejak pertama kali dikenalkan oleh Leonhard Euler pada 1736. Topik yang terus dikembangkan adalah pelabelan graf yang salah satu jenisnya adalah pelabelan  Pelabelan  didefinisikan sebagai fungsi yang memetakan titik graf ke bilangan bulat non negatif dengan syarat titik yang berjarak satu memilik mutlak selisih label minimal dua dan titik yang berjarak dua memiliki mutlak selisih label minimal satu. Konsep pelabelan  terfokus dalam menentukan nilai minimum label terbesar yang dinotasikan dengan . Dalam paper ini akan dibahas ini akan dibahas mengenai pelabelan  pada graf gunung api, graf pot bunga, dan graf pohon palem.
Pelabelan L(2,1) Pada Graf Hasil Amalgamasi Titik
Authors: Komarullah Hafif
Published: January 2025

Pelabelan graf merupakan salah satu topik dalam teori graf yang terus eksis. Pelabelan graf merupakan suatu teknik pemberian label berupa bilangan bulat non negatif pada anggota graf berupa titik, sisi, atau keduanya dengan syarat-syarat tertentu. Salah satu pelabelan titik adalah pelabelan L(2,1) yang didefinisikan sebagai pemetaan titik graf ke bilangan bulat non negatif dengan syarat titik yang berjarak satu memiliki mutlak selisih label minimal dua dan titik yang berjarak dua memiliki mutlak selisih label minimal satu. Paper ini akan mencari nilai minimum label terbesar atau disebut nilai minimum  pada graf hasil amalgamasi titik.  Graf  adalah graf yang diperoleh dengan  salinan dari graf  dengan mengidentifikasi  salinan dari graf  pada titik tetap . Graf yang dipilih dalam paper ini adalah graf  dengan  merupakan graf kipas, graf roda, graf bunga, dan graf (CnxP2)+K1.
Modifikasi Sandi Algoritma Hill Cipher Dengan Kunci Berentry Barisan Fibonaci
Authors: Nurfadila Rizqy Amalia , Komarullah Hafif , Saputri Maura Delva
Published: January 2025

Teknologi komunikasi semakin canggih, teknologi ini sangat dibutuhkan dan dimanfaatkan secara berkelanjutan oleh manusia. sehingga perlu adanya pengamanan dalam menggunakan teknologi komunikasi saat ini. Kriptografi merupakan cabang ilmu matemtatika yang mempelajari tentang penyandian pesan. Kriptografi sudah berkembang sejak tahun 1970. Enkripsi digital dimulai pada tahun 1970 dengan upaya Feistel IBM dan mencapai puncaknya pada tahun 1977 ketika Amerika Serikat mengadopsi sistem enkripsi DES (Data Encryption Standard). Standar pemrosesan data federal untuk enkripsi informasi rahasia. Terdapat banyak macam algoritma dalam enkripsi kriptografi salah satunya algoritma Hill Cipher. Hill cipher merupakan salah satu algoritma kriptografi kunci simetris. Algoritma Hill cipher menggunakan matriks berukuran  sebagai kunci untuk melakukan enkripsi dan dekripsi. Dalam penelitian ini peneliti memanfaatkan barisan fibonaci sebagai kunci dalam melakukan enkripsi dan deskripsi pada algoritma Hill cipher.
A Case of Harlequin Ichthyosis: Improvement Survival Rate with Early Isotretinoin Therapy
Authors: Tanasal Hanny , Michaela Iline , Danarti Retno
Published: January 2025

Harlequin ichthyosis (HI) is among the most severe hereditary skin conditions of autosomal recessive congenital ichthyosis (ARCI) in newborns, associated with a mutation of the ABCA12 gene. Patients have a typical clinical appearance at birth. A thick layer of armor-like scales covers the entire body. Affected newborns have abnormal facial features, such as ectropion, eclabium, and ears and nose flattening. Although HI was formerly assumed to be fatal, more intensive neonatal care and early retinoid therapy may improve the patients' survival rates. This case report aims to present a case of a 5-year-old boy born with HI who survived with isotretinoin treatment since day 5 of life. Despite advances in medical care, HI remains a challenging condition with an abnormality that lasts a lifetime and can lead to a variety of medical difficulties following birth.
Effects of an e-learning program (PEAK, physiotherapy exercise and physical activity for knee osteoarthritis) on Chinese physical therapists' confidence and knowledge: a randomized controlled trial (Preprint)
Authors: Wang Zi-Ru , Wang Yunqi , Duan Shuning , Chen Xier , Ni Guoxin
Published: January 2025

BACKGROUND

Knee osteoarthritis (OA) imposes a significant burden in China due to its high prevalence, aging population, and rising obesity rates. Despite clinical guidelines recommending evidence-based care, limited practitioner training and inadequate telehealth integration hinder effective OA management.

OBJECTIVE

To evaluate the effectiveness of an e-learning program in improving the confidence and knowledge of Chinese physical therapists in managing knee OA and to explore their perceptions of the program.

METHODS

A randomized controlled trial with two parallel arms involved 81 rehabilitation practitioners from 18 Chinese provinces. The intervention group completed a four-week online training program (PEAK-Chinese), while the control group received no training. Primary outcomes were self-reported confidence in OA management (11-point scale). Secondary outcomes included knowledge (Chinese Knee Osteoarthritis Knowledge Scale, KOAKS) and likelihood of clinical application of core OA treatments. Process measures and semi-structured interviews captured participants' training perceptions. Quantitative data were analyzed using regression models, t-tests, and descriptive statistics, while interviews with 10 participants underwent thematic analysis.

RESULTS

A total of 80 participants completed the outcome measures at 4 weeks. The intervention group demonstrated significant improvements in confidence for managing OA with exercise-based programs (adjusted mean difference [AMD] = 3.27, 95% CI: 2.72–3.81), prescribing exercise (AMD = 3.13, 95% CI: 2.55–3.72), and delivering telehealth (AMD = 4.41, 95% CI: 3.77–5.05). KOAKS scores also improved significantly (mean change = 9.46); however, such as those about OA concepts and the use of scans, remained unchanged. Over 60% of intervention participants rated the course as "extremely useful." Interviews emphasized the need for cultural adaptation and practical telehealth training with real-life scenarios to enhance program applicability.

CONCLUSIONS

The PEAK program improved Chinese practitioners' confidence and knowledge in managing knee OA, underscoring e-learning's potential to support evidence-based OA care in China. Enhancing cultural relevance and incorporating practical training could further optimize its clinical applicability.

CLINICALTRIAL

ChiCTR2400091007
mHealth real-world implementation and patient safety: A multi- center qualitative study (Preprint)
Authors: Su Jing Jing , Chan Michelle Hui Shan , Ghisi Gabriela Lima de Melo , Kwan Rick Yiu Cho , Wong Arkers Kwan Ching , Lin Rose Sin Yi , Yeung Jerry Wing Fai , He Qijun , Pepera Garyfallia , Batalik Ladislav
Published: January 2025

BACKGROUND

Mobile health (mHealth) is increasingly being used in contemporary healthcare provision owning to its portability, accessibility, facilitation of communication, improved inter-professional collaboration, and benefit health outcomes. However, there is limited discourse on patient safety in real-world mHealth implementation, especially as care settings extend beyond traditional centre-based technology usage to home-based care.

OBJECTIVE

This study aims to explore healthcare professionals’ perspectives on the safety aspects of mHealth integration in real-world service provision, focusing on Hong Kong SAR and Wuhan city in mainland China.

METHODS

A multi- centre qualitative study design was used. Twenty-seven participants, including 22 nurses and five physicians from two different healthcare systems were interviewed individually. Thematic analysis was used to analysis the data.

RESULTS

Four themes emerged from the data analysis. Participants emphasized 'liability' concerns when discussing patient safety, considering the current uncertainties surrounding mHealth implementations. They emphasized the need for 'change management,' which includes appropriate referral processes, adequate resources and funding, informed mHealth usage, and efficient working processes. They cautioned the risks in providing mHealth information without ensuring understanding, appreciated the current regulations available, and identified additional regulations that should be considered to ensure information security.

CONCLUSIONS

Healthcare professionals recognized the importance of patient safety in mHealth usage. The promotion of mHealth should be accompanied by the standardization of mHealth services with institutional and healthcare system-level support. This includes fostering mHealth acceptance among healthcare professionals to encourage appropriate referrals, accommodate changes, ensure patient comprehension, and proactively identify and address threats to information security.
Appeal of Editor-in-Chief
Authors: Authors No
Published: January 2025

No abstract
Diagnostic and therapeutic challenges in dense deposit disease: case report
Authors: Prasad Anand , Jain Dhruv , Jaiswal Navya , Shahi Harsha
Published: January 2025

We report a complex case of a 15-year-old girl initially diagnosed with post-streptococcal glomerulonephritis (PSGN) but later identified as having dense deposit disease, which was initially classified as type 2 membranoproliferative glomerulonephritis. PSGN and C3 glomerulopathy present overlapping clinical and histological features, complicating diagnosis and treatment. This report highlights the case of a young patient whose initial presentation and management for PSGN transitioned to a complex diagnosis of dense deposit disease, necessitating tailored therapeutic interventions.
FORMULATION AND EVALUATION OF AN ORAL TIMED PULSATILE DRUG DELIVERY FOR ALLEVIATING PAIN IN RHEUMATOID ARTHRITIS
Authors: JYOTHIRMAYI PASAM , BHARATHI ARIGELA , REDDY D. RAMA SEKHARA
Published: January 2025

Objective: The present study was aimed to formulate and evaluate an oral timed-release pulsatile drug delivery of AcecloFenac (AF) for rheumatoid arthritis pain by the Chronopharmaceutical approach with early morning breakthrough of AF as analgesic and anti-inflammatory agent for the treatment of rheumatoid arthritis.
Methods: A solubility was enhanced by formulating it as a self-emulsified system with a suitable oil and surfactant mixture. The interaction between the drug and the excipient was examined using Fourier Transform Infra-Red (FTIR) spectroscopy. The prepared formulation consists of 2 different parts: The basic design consists of burst-release core tablets with solid self-emulsified AF by using different super disintegrants, and the press-coating of optimised tablets by using different compositions of Ethylcellulose (hydrophobic) and Hydroxy Propyl Methyl Cellulose (HPMC K100) (hydrophilic) polymers.
Results: FTIR studies revealed no interaction between drug and excipients. From the solubility data, suitable oil and surfactants were selected. Pseudo-ternary plots help in finding of suitable surfactant mixtures for solid self-emulsified AF. Core tablets were evaluated for pre-compression characteristics, disintegration time, drug content, weight variation, hardness, friability, thickness, and % drug release. Among all solid self-emulsified formulations, S1C6 is successful, with 98.88% drug release in 20 min. The compression coat formulations were also evaluated for Hardness, weight variation, thickness, lag time, and in vitro drug release profile. Among them, F4 was optimised by its suitable lag time and drug release of 97.23% at the end of 6 h.
Conclusion: The system released the drug after a predetermined lag time of 4 h and thus, the dosage form can be taken at bedtime so that the drug will be released when the symptoms are prominent. Nine formulations were prepared, of which F4 formulation showed the highest drug release of 97.23 % at the end of 6 h and showed compliance with the chronotherapeutic objective of rheumatoid arthritis.
GC-MS ANALYSIS AND MOLECULAR DOCKING STUDIES OF Laserpitium LATIFOLIUM L EXTRACT FOR ANTI-DIABETIC ACTIVITY
Authors: MUKKA DIVYA , DEVARAKONDA KRISHNA PRASAD
Published: January 2025

Objective: To assess the anti-diabetic activity of Lasterpitium latifolium l extract through computational docking studies.
Methods: Crude extract of Lasterpitium latifolium l whole plant was obtained using a rotary evaporator. The extract was analyzed for bioactive compounds using Gas chromatography/Mass spectrometry (GC-MS). The extract was examined for their anti-diabetic effects through computational docking studies and in vitro. For docking studies, proteins of diabetes mellitus, α-amylase and α-glucosidase, were selected from the literature.
Results: Binding affinity assessed by score function identified 2,4-Thiazolidinedione, 5-[[4-(4-pyridinyl)-6-quinolinyl] methylene]-(5Z)-(highest docking score of-7.8 kcal/mol) and cycloartenol acetate (docking score of-7.5kcal/mol) are the most promising compounds that showed strong affinity to target proteins of diabetes mellitus. These compounds have the highest docking scores, suggesting that they are potential candidates for anti-diabetic drug development. Extract of L. latifolium exhibited 68.1% potent activity at 250 μg/ml.
Conclusion: In the anti-diabetic potential of crude extracts, multiple pancreatic and extra-pancreatic mechanisms may occur synergistically to achieve a strong anti-diabetic effect.
Factores asociados al alfabetismo científico en estudiantes de medicina de una universidad del Perú
Authors: Quinde-Ramos Brisa , Yupanqui-Bautista Cristhian , Tasayco-Bazalar Andrea , Romaní-Romaní Franco
Published: January 2025

Introducción: El alfabetismo científico es un conjunto de habilidades requeridas para explicar científicamente los fenómenos e interpretar los resultados de la investigación científica. Estas habilidades no han sido medidas en estudiantes de medicina de Perú, ni se conocen qué factores lo explican.
Objetivo: Identificar los factores asociados al alfabetismo científico en estudiantes de medicina.
Método: Se realizó un estudio transversal en 299 estudiantes de medicina de una universidad privada de Lima, Perú. Fue aplicado un cuestionario autoadministrado que incluyó un instrumento de 28 ítems para medir el alfabetismo científico (TOSLS-español); además, se recogió información sobre edad, sexo, escuela de procedencia, año de estudio, y estudios universitarios previos. Finalmente, se obtuvo el promedio ponderado y condición de becado de los estudiantes. El puntaje mínimo y máximo para el TOSLS-español fue de 0 y 28. Se evaluó a nivel crudo la asociación entre el número de respuestas correctas en el TOSLS-español (variable dependiente) y las variables asociadas, aquellas que alcanzaron un p<0,25 fueron incluidas en un modelo lineal generalizado para un desenlace con distribución de Poisson.
Resultados: La mediana del número de respuestas correctas fue 19. Ser mujer redujo en 8% el número de respuestas correctas respecto a los varones, el ser del quinto y sexto año incrementó en 10% y 11% el puntaje en el TOSLS-español comparado con el primer año. Finalmente, el incremento de un punto en el promedio ponderado incrementó en 7% el número de respuestas correctas.
Conclusiones: Entre estudiantes de medicina el número de respuestas correctas en un instrumento de alfabetismo científico estuvo determinado por el sexo, el año de estudio y el rendimiento académico medido por el promedio ponderado.
Oxidative degradation by Fenton's Method for ten pharmaceutical drugs largely used in a Brazilian City
Authors: Fonte Boa Taís , Lima Santos Larissa Ribeiro , Ribeiro Vasconcelos Olívia M. S. , Moreira Carolina Paula de Souza , Starling Sérgia Maria Magalhães , Pataca Luiz Carlos Moutinho , Mol Marcos Paulo Gomes
Published: January 2025

Medicines have been recently recognized as one of the emerging contaminants in the environment. These are discharged after therapeutic use through human excretion or irregular discharges. Effluent containing high concentrations of drugs discharged from production facilities is also a cause of concern to nearby aquatic bodies. There is an increased interest in their removal due to environmental and public health problems related. Some drugs are resistant to conventional methods of liquid effluent treatment, and there is a risk of negative impacts in humans and animals if exposed repeatedly to the same medicines for prolonged periods. To date, the potential human, animal, and ecological risks associated with the discharge of these compounds to the environment and the potential techniques for liquid effluent degradation demand to be well discussed. Fenton degradation process represents one possibility of pharmaceutical removal of liquid effluents, as presented by the scientific literature. Therefore, this study presents a brief summary on Fenton degradation studies of ten of the most used drugs in city of Belo Horizonte, the capital of the state of Minas Gerais, Brazil. The result of the literature search about the studies of oxidative degradation of the drugs resulted in 45 articles found, applied to 6 drugs among the 10 most frequently used in Belo Horizonte. The needs regarding removal, disposal, and treatment of drugs represent an important challenge in environmental management.
As contribuições da reciclagem para o desenvolvimento sustentável: uma revisão bibliográfica
Authors: Cezário Janaína Aparecida , Bezerra do Nascimento Maxsuel , Leal dos Santos Laércio , De Paiva William
Published: January 2025

Este trabalho apresenta uma revisão bibliográfica sobre as contribuições da reciclagem para o desenvolvimento sustentável. O cenário contemporâneo exige soluções para a coexistência harmoniosa entre avanço econômico e preservação ambiental. Nesse contexto, a reciclagem emerge como uma peça-chave, orquestrando uma série de contribuições significativas para o desenvolvimento sustentável. A reciclagem é discutida como uma estratégia fundamental para a redução de resíduos sólidos, a preservação de recursos naturais e a promoção de uma gestão mais eficiente dos materiais, como também, uma fonte de criação de empregos e inclusão social. Através da análise de estudos de diferentes autores, examina-se como a reciclagem contribui para a diminuição da poluição ambiental, a geração de emprego e renda, a inclusão social e a conscientização ambiental. Além disso, são exploradas as implicações da reciclagem em setores específicos, como a construção civil. A revisão bibliográfica demonstra a relevância da reciclagem como uma ferramenta chave na busca por um desenvolvimento mais sustentável, enfatizando sua capacidade de promover a economia circular e a coesão social.
Opportunities of Biochar in Kanchanpur District of Nepal
Authors: Pant Janak
Published: January 2025

The soil fertility and production were observed to be poor and declining in the district. So, an experiment was
conducted to determine the opportunity of innovative and sustainable biochar in soil properties and crop production. The
experiment was laid out in Randomized Complete Block Design (RCBD). The research was conducted during November 2022 to
May 2023 in Kanchanpur district of Nepal. Six different treatments namely, sheep manure, rice husk, poultry manure, farmyard
manure and wood including one control was applied in the research. Tomato crop was selected for the research crop. Rice husk
was found most effective in crop attributes and yield. The average numbers of leaves after 20 and 40 days of transplantation of
tomato were 9, 7, 6, 6, 5, 4 and 9, 8, 6, 6, 5, 4 by the application of rice husk, poultry manure, farmyard manure, sheep manure,
wood, and control respectively. The average yield (kg/plant) was 14, 12, 11, 11, 10 and 7 through the treatments of rice husk,
poultry manure, farmyard manure, sheep manure, wood, and control respectively. The soil pH in poultry manure and wood were
significantly similar and higher than other biochar treatments. Sheep manure biochar was a highly significant and effective
source of nitrogen which was followed by poultry manure, rice husk/wood and control. Organic matter content was higher in
sheep manure biochar followed by poultry manure, rice husk/wood, farmyard manure and control. Rice husk, sheep manure and
poultry manure were effective sources of biochar, though other sources have equal importance in soil properties and crop yield
or yield attributes. All the biochar sources found with their own benefits and scope in soil enhancement and crop production in
the district.
Identifying Deepfake Cyber Attacks: Challenges and Countermeasures
Authors: Trivedi Aayush
Published: January 2025

Deepfake technology has emerged as a major cybersecurity threat, enabling sophisticated cyber attacks that exploit
artificial intelligence (AI) and machine learning (ML).
This paper explores the methodologies used to detect deepfake-based cyber threats, including image and video forensics, AIdriven detection systems, and biometric verification. Additionally, countermeasures such as blockchain authentication and
adversarial training are examined. A comprehensive review of deepfake detection datasets is also provided, discussing their
efficacy and relevance. This study aims to enhance awareness and develop robust mitigation strategies against deepfake cyber
threats
Humane Interrogation Strategies Predict Suspects’ Decisions to Confess, Cooperate, and Disclose Information
Authors: Bettens Talley , Cleary Hayley , Bull Ray
Published: January 2025

Take Home Messages:

The techniques used to interrogate criminal suspects can profoundly impact their decisions to confess, cooperate, or disclose information. The source article assessed how interrogation strategies characterized by humanity, rapport, confrontation, and dominance predicted interrogation outcomes in a sample of 249 incarcerated individuals in the United States (U.S.).
Survey respondents who reported experiencing humane interrogation strategies were more likely to cooperate completely with police, disclose incriminating information, and confess, whereas interrogations involving confrontation and dominance did not impact their interrogation outcomes.
Humane interrogation strategies are likely the most productive for police to adopt in criminal interrogations. Police should avoid using interrogation approaches that focus on dominance and confrontation, which can be classified under the broader umbrella of accusatorial methods.
Cognitive Interview Conducted In-Person and Over-the-Phone For Informants' Memory of Overheard Conversations
Authors: Sneyd Danielle , Fisher Ronald P.
Published: January 2025

A laboratory simulation study compared the Cognitive Interview to the standard police interview for informants’ memories of a conversation. The interviews were conducted live or on the telephone.
The Cognitive Interview elicited 61% more relevant details than the standard interview. There was no difference between interviews conducted in-person versus on the telephone.
The results suggest that the Cognitive Interview will be a beneficial tool for eliciting details about overheard conversations. Furthermore, information will not be lost if the interview is conducted over the telephone.
Editors' Note
Authors: Bennell Craig , Luther Kirk
Published: January 2025

We're thrilled to introduce the third issue of Applied Police Briefings! Please check out our Editors' Note for more information about the journal.
Finding the Path of Least Resistance: An Examination of Officer Communication Tactics and Their Impact on Suspect Compliance
Authors: Foster Jacob T. , Zimmerman Laura , Terrill William , Somers Logan J.
Published: January 2025

In cases where officers communicated with a positive tenor (e.g., demeanor), suspects were compliant 99.3% of the time. Similarly, the use of noncoercive verbal communication and directives (e.g., asking, suggesting, persuading) were also shown to significantly increase suspect compliance. However, accusing suspects of wrongdoing and using other coercive language, such as threats and commands, did not significantly impact suspect compliance.
These results highlight the need for police training programs to prioritize communication skills that minimize the use of force when possible. Focusing on noncoercive directives and exhibiting a positive tenor could mitigate the likelihood of suspect resistance or noncompliance, thereby reducing the need for physical intervention and possible injuries to those involved. Prior literature also suggests these strategies may be important for improving community relations and perceptions of police legitimacy.
Differences Between Visual Search Behaviour and Body-Worn Camera Footage During a Use of Force Response by Active-Duty Police Officers
Authors: Murray Nicholas P. , Lewinski William , Allen Craig , Heidner Gustavo S. , Albin Michael W. , Horn Robert
Published: January 2025

Officers have visual scan strategies and rely on neck and head actions when scanning for threats that provide a wider field of view than a body-worn camera (BWC). The study in the source article determined how an officer’s visual scanning of a simulated use of force encounter differed from digital information captured by BWCs.
Officers detected behavioural cues of actual and potential threats in the encounter that the BWCs missed. In fact, eye-tracking glasses worn by officers captured every pre-determined critical event examined by the researchers more frequently than their BWCs.
During post-event investigations of use of force incidents, the interpretation of footage from BWCs may lead to faulty conclusions by missing critical events that drive officer actions but are not captured by their BWC.
Disclosing Evidence in Investigative Interviews: What Can the Research Tell Us and What Does it Mean for Training?
Authors: Oleszkiewicz Simon , Watson Steven J.
Published: January 2025

Research shows that attempting to pressure and overwhelm interviewees to align with evidence by, for example, disclosing too much evidence at the earlier stages of an interview often results in unreliable statements and can facilitate opportunities for deceptive interviewees to deceive convincingly.
By encouraging interviewees to address the available evidence before disclosing it (late timing of disclosure) or drip-feeding the evidence throughout an interview (gradual method of disclosure), it becomes easier to elicit and explore statements that contradict available evidence; and these disclosure methods may encourage interviewees to reveal information that facilitate more accurate credibility assessments.
Due to the uncertainty and unpredictability of operational interviews compared to laboratory studies, training on evidence disclosure should focus on appropriate adaptive use rather than pure implementation of theoretical frameworks and protocols.
A Rule of Thumb for Deception Detection: Focus Only on the Details
Authors: Pfründer Lucca , Meissner Christian A. , Verschuere Bruno
Published: January 2025

People, including the police, are poor at detecting lies.
The level of detail in a statement speaks to its credibility – truthful statements contain more details than false statements.
Focusing solely on the level of detail in a statement, rather than considering multiple indicators, may improve lie detection ability
Developing a Competency Framework for Police Incident Commanders
Authors: Ferguson Lorna , Huey Laura , Kalyal Hina , Andersen Judith P.
Published: January 2025

The competency framework developed from this study involves seven thematic categories with distinct and interrelated concepts essential for effective police incident command.
The selection and training of Incident Commanders (ICs) should consider both technical skills and also traits such as humility, emotional stability, and approachability, which are challenging to teach but vital for leadership and teamwork. To that end, traditional police training or years of experience are insufficient for the specific demands of incident command. Scenario-basedtraining is necessary to prepare ICs for situations they manage in this role.
Understanding how stress affects decision-making and providing stress management training can help improve the performance and well-being of ICs during incidents.
The Hidden Cost: Mental Health Absences in Policing
Authors: Quin Emily
Published: January 2025

The source article highlights the increasing trend of psychological illnesses and stress-related absences of officers in frontline and ‘Response’ roles in England and Wales.
Figures recorded between 2019 and 2023 indicate that absences related to psychological illness were rising at rates at least double those of other sickness absences.
Officers are facing significant challenges due to work-related stress, trauma, and psychological strain, which may be attributed to an increase in demand and a decrease in resourcing.
The findings emphasize the need for better mental health support, targeted interventions, and the development of policies aimed at mitigating workplace stress and its impacts on police officers’ wellbeing.
Impacto ecológico por el uso de leña en una comunidad de alta montaña en Tamaulipas, México
Authors: Andrade Limas Elizabeth Del Carmen , Navarro López Valeria , Treviño Carreón Jacinto , Ventura Houle René , Macías Hernández Bárbara Azucena
Published: January 2025

Los bosques de alta montaña, son el hábitat de una amplia diversidad de especies vegetales. En los hogares rurales, la biomasa leñosa de los bosques, es la principal fuente de combustible, tanto para cocinar, como para calefaccionar en época de frío. El objetivo de la investigación, fue determinar las relaciones de las familias rurales con los recursos vegetales, mediante el uso de leña en fogones abiertos. Las variables estudiadas, fueron el consumo, la extracción, el uso y manejo de especies leñosas y los procesos relacionados con el impacto en la estructura de la vegetación arbórea, en una comunidad de alta montaña, en Miquihuana, Tamaulipas, México. Se aplicó una encuesta a los habitantes, para conocer las especies forestales utilizadas como biocombustible, cantidad de leños, distancia recorrida para su obtención y mediante el uso de imágenes de satélite, se obtuvo el índice de diferencia normalizada de vegetación (NDVI). Se encontró una pérdida de cobertura vegetal de 7.7%, entre 2010 y 2020; las principales especies utilizadas, son encino (Quercus mexicana) y pino (Pinus pseudostrobus), debido a sus características de combustión y duración de la flama, así como la cantidad de biomasa utilizada por familia al año, que es aproximadamente de 74.0 m3. La densidad de las especies, disminuye principalmente, por la extracción de leña para el uso doméstico, debido a que es una actividad que se lleva a cabo día con día. Esto indica que, existe un impacto negativo en los bosques y es necesario aplicar acciones que ayuden a su recuperación.