bluuebunny/crossref_metadata_2025 huggingface dataset:
What determines the information update rate in echolocating bats
Authors: Taub Mor , Goldshtein Aya , Boonman Arjan , Eitan Ofri , Hurme Edward , Greif Stefan , Yovel Yossi
Published: November 2023

The rate of sensory update is one of the most important parameters of any sensory system. The acquisition rate of most sensory systems is fixed and has been optimized by evolution to the needs of the animal. Echolocating bats have the ability to adjust their sensory update rate which is determined by the intervals between emissions - the inter-pulse intervals (IPI). The IPI is routinely adjusted, but the exact factors driving its regulation are unknown. We use on-board audio recordings to determine how four species of echolocating bats with different foraging strategies regulate their sensory update rate during commute flights. We reveal strong correlations between the IPI and various echolocation and movement parameters. Specifically, the update rate increases when the signals’ peak-energy frequency and intensity increases while the update rate decreases when flight speed and altitude increases. We suggest that bats control their information update rate according to the behavioral mode they are engaged in, while always maintaining sensory continuity. Specifically, we suggest that bats apply two modes of attention during commute flights. Our data moreover suggests that bats emit echolocation signals at accurate intervals without the need for external feedback.
Evidence for high-frequency oxygenation of Ediacaran shelf seafloor during early evolution of complex life
Authors: Jiao Liangxuan , She Zhenbing , Papineau Dominic , Zhang Chao , Algeo Thomas J. , Dodd Matthew S. , Luo Genming , Cao Kenan , Li Chao
Published: November 2023

Increasing oxygenation of the early Ediacaran Ocean is thought to have been responsible for the emergence of early animals. Although geochemical studies have suggested periods of oceanic oxygenation in the Ediacaran, direct evidence for seafloor oxygenation has been lacking. Here, we report frequent occurrences of distinctive, sub-millimetric, and early diagenetic pyrite-marcasite rosettes in phosphorites from the lower Ediacaran Doushantuo Formation (Weng’an, South China). They typically consist of a nucleus of framboidal pyrite, a cortex of radiating marcasite blades intergrown with quartz, and a rim of second-generation pyrite, recording partial oxidative dissolution of pyrite and co-precipitation of marcasite and quartz. This inference is further supported by near-zero carbon isotope values of the host dolostone, similarly low sulfur isotope values for pyrite and marcasite, and evident Fe-isotope fractionation between marcasite and pyrite. Collectively, our findings reveal intermittent bottom-water and porewater oxygenation events, providing direct evidence of high-frequency oxygenation of Ediacaran continental shelves.
Determination of seroprevalence and kinetics of humoral response using mpox virus A29 protein
Authors: Cai Jian-Piao , Chu Wing-Ming , Tam Anthony Raymond , Wang Kun , Han Yuting , Chen Lin-Lei , Zhang Xiaojuan , Choi Charlotte Yee-Ki , Cheng Vincent Chi-Chung , Chan Kwok-Hung , Chen Zhiwei , Hung Ivan Fan-Ngai , Fong Carol Ho-Yan , To Kelvin Kai-Wang
Published: November 2023

Background

Mpox virus (MPXV), previously known as monkeypox virus, has spread globally in 2022. An accurate and convenient antibody test is essential for the determination of seroprevalence and for studying immune response after natural infection or vaccination. Most seroprevalence or vaccine studies used either live MPXV (or vaccinia virus [VACV]) or inactivated MPXV (or VACV) culture lysate for serological assays, but MPXV culture can only be performed in biosafety level 3 (BSL-3) facilities. Here, we developed and evaluated an enzyme immunoassay (EIA) based on the MPXV A29 surface envelope protein.

Methods

We compared the specificity of the MPXV A29, VACV A27, and VACV lysate EIA using serum specimens collected prior to the global spread of MPXV. Next, we performed these EIAs for serum specimens collected from two mpox patients and an MVA-BN vaccine recipient. We also assessed the kinetics of plasmblast and MPXV A29-specific B-cell response.

Results

Using sera collected from different age groups in Hong Kong, we found that most individuals, including those born before 1981 who have received the smallpox vaccine, tested negative using the MPXV A29 protein. MPXV A29-specific antibody could be detected in the serum of mpox patients and an MVA-BN recipient. In a mpox patient, the frequency of plasmablast and MPXV A29-specific B cell peaked on day 8 post-symptom onset and gradually decreased. Finally, we demonstrated that antibodies against the A29 protein can be used for immunofluorescence staining of MPXV-infected cells.

Conclusions

MPXV A29 protein is suitable for studying the immune response against MPXV infection.
Symmetry of the emergent inductance tensor exhibited by magnetic textures
Authors: Furuta Soju , Koshibae Wataru , Kagawa Fumitaka
Published: November 2023

Metals hosting gradually varying spatial magnetic textures are attracting attention as a new class of inductors. Under the application of an alternating current, the spin-transfer-torque effect induces oscillating dynamics of the magnetic texture, which subsequently yields the spin-motive force as a back action, resulting in an inductive voltage response. In general, a second-order tensor representing a material’s response can have an off-diagonal component. However, it is unclear what symmetries the emergent inductance tensor has and also which magnetic textures can exhibit a transverse inductance response. Here, we reveal both analytically and numerically that the emergent inductance tensor should be a symmetric tensor in the so-called adiabatic limit. By considering this symmetric tensor in terms of symmetry operations that a magnetic texture has, we further characterize the magnetic textures in which the transverse inductance response can appear. This finding provides a basis for exploring the transverse response of emergent inductors, which has yet to be discovered.
An intelligent readable and capture-antibody-independent lateral flow immunoassay based on Cu2−xSe nanocrystals for point-of-care detection of Escherichia coli O157:H7
Authors: Yao Yiyun , Hou Li , Wei Fenghuang , Lin Tianran , Zhao Shulin
Published: November 2023

An intelligent readable and capture-antibody-independent LFIA platform was constructed based on Cu2−xSe NCs for the POCT detection of Escherichia coli O157:H7.
Correction: Graphene oxide-mediated fluorescence turn-on GO-FAM-FRET aptasensor for detection of sterigmatocystin
Authors: Gade Pravin Savata , Sonkar Rutuja Murlidhar , Bhatt Praveena
Published: November 2023

Correction for ‘Graphene oxide-mediated fluorescence turn-on GO-FAM-FRET aptasensor for detection of sterigmatocystin’ by Pravin Savata Gade et al., Anal. Methods, 2022, 14, 3890–3897, DOI: https://doi.org/10.1039/D2AY01405J.
Nano-in-nano enteric protein delivery system: coaxial Eudragit® L100-55 fibers containing poly(N-vinylcaprolactam) nanogels
Authors: Sonzogni Ana , Rivero Guadalupe , Gonzalez Verónica , Abraham Gustavo , Calderón Marcelo , Minari Roque
Published: November 2023

Novel nano-in-nano coaxial platform for enteric protein delivery.
Accurate assessment of electrocatalytic carbon dioxide reduction products at industrial-level current density
Authors: Zi Xin , Liu Qiuwen , Zhu Li , Chen Qin , Liao Xiangqiong , Mei Ziwen , Wang Xiaojian , Wang Xiqing , Liu Kang , Fu Junwei , Liu Min
Published: November 2023

The FE of CO2RR products seriously deviates from 100% due to the misjudgment of outlet flow at large current density. Several modified equations and calibration methods are recommended to establish benchmarks for CO2 reduction product assessment.
High-pressure induced guest-mediated gate opening behaviour of the Co-based framework ZIF-67
Authors: Jones Isabelle M. , Turner Gemma F. , Pitts Kari , Powell Rees , Riboldi-Tunnicliffe Alan , Williamson Rachel , Boer Stephanie , Allen Lauren , Moggach Stephen A.
Published: November 2023

Compression of a Co(ii) metal–organic framework, ZIF-67, to gigapascal pressures demonstrated gate-opening behaviour at different pressures in methanol/ethanol and N2. N2 adsorption also elicited a blue to purple colour transition.
Analysis and interpretation of first passage time distributions featuring rare events
Authors: Woods Esmae J. , Wales David J.
Published: November 2023

Network reduction and graph transformation enable the computation of first passage time distributions in large ill-conditioned systems exhibiting rare events.
Solution-grown millimeter-scale Mn-doped CsPbBr3/Cs4PbBr6 crystals with enhanced photoluminescence and stability for light-emitting applications
Authors: Peng Wenfang , Hu Rongrong , Yang Bobo , Wu Qiaoyun , Liang Pan , Cheng Lin , Cheng Xixi , Li Yuefeng , Zou Jun
Published: November 2023

Comparison of solution-grown millimeter-scale Mn-doped and undoped CsPbBr3/Cs4PbBr6 crystals, (left) PL spectra, photographs of Mn-doped CsPbBr3/Cs4PbBr6 crystals and (right) stability.
Modulating the electronic properties and band alignments of the arsenene/MoSi2N4 van der Waals heterostructure via applying strain and electric field
Authors: Zhao Jun , Qi Yunxi , Yao Can , Zeng Hui
Published: November 2023

The physical mechanism of manipulating the arsenene/MoSi2N4 heterostructure via applying in-plane/vertical strain and electric field to achieve nanoelectronic and optoelectronic applications is explored.
Carbon dioxide activation by discandium dioxide cations in the gas phase: a combined investigation of infrared photodissociation spectroscopy and DFT calculations
Authors: Liu Pengcheng , Han Jia , Chen Yan , Lu Shun , Su Quyan , Zhou Xiaoguo , Zhang Weijun
Published: November 2023

A combined infrared experimental and density functional theory study revealed the possibility of co-existing isomers containing end-on and carbonate structures in the [Sc2O2(CO2)n]+ (n = 1–4) complexes.
Vacancy-rich Al-doped MnO2 cathodes break the trade-off between kinetics and stability for high-performance aqueous Zn-ion batteries
Authors: Zhao Yajun , Zhang Shuoxiao , Zhang Yangyang , Liang Jinrui , Ren Longtao , Fan Hong Jin , Liu Wen , Sun Xiaoming
Published: November 2023

A novel vacancy-rich, Al-doped MnO2 cathode is proposed for AZIBs, showcasing 3D ion diffusion channels and excellent structural stability. It overcomes the trade-off between electrode kinetics and stability, delivering impressive rate performance and outstanding capacity retention.
Au nanoparticle decorated reduced graphene oxide and its electroanalytical characterization for label free dopamine detection
Authors: Ingrosso Chiara , Corricelli Michela , Testolin Anna , Pifferi Valentina , Bettazzi Francesca , Bianco Giuseppe V. , Depalo Nicoletta , Fanizza Elisabetta , Striccoli Marinella , Palchetti Ilaria , Curri M. Lucia , Falciola Luigi
Published: November 2023

Au nanoparticle decorated RGO as effective nanocomposite for label-free electrochemical detection of dopamine.
A magnetic Fe@PANI catalyst for the selective oxidation of sulphide under mild and green conditions
Authors: Wu Xiaohe , Chen Ying , Zhang Yiyang , Zhang Xu , Yu Lei
Published: November 2023

A novel polyaniline-supported iron catalyst (Fe@PANI) for sulphide oxidation is designed and synthesized. The material exhibits magnetism and can be recycled by magnetic separation and reused without deactivation.
Full automation of point defect detection in transition metal dichalcogenides through a dual mode deep learning algorithm
Authors: Yang Dong-Hwan , Chu Yu-Seong , Okello Odongo Francis Ngome , Seo Seung-Young , Moon Gunho , Kim Kwang Ho , Jo Moon-Ho , Shin Dongwon , Mizoguchi Teruyasu , Yang Sejung , Choi Si-Young
Published: November 2023

We advocate for the development of expertise in visualizing and identifying point defects in two-dimensional (2D) materials, a skillset intimately linked to a wide array of physical phenomena.
Atropisomerism about aryl–C(sp3) bonds: chemically driven rotational pathway in cannabidiol derivatives
Authors: Denhez Clément , Lameiras Pedro , Berber Hatice
Published: November 2023

Among the two possible pathways to reach (M) and (P) conformers in CBD derivatives, the rotation through TS1 is preferred in arylcyclohexene and TS2 in arylcyclohexane series.
Application of engineered myoglobins for biosynthesis of clofazimine by integration with chemical synthesis
Authors: Tang Shuai , Sun Li-Juan , Pan Ai-Qun , Huang Jun , Wang Huamin , Lin Ying-Wu
Published: November 2023

Engineered myoglobins (Mbs), such as F43Y/T67R Mb, were applied to catalyze the oxidative coupling of N-4-CPBDA to produce N-5-CCPIPA in the presence of H2O2, which was further combined with chemical synthesis for the total synthesis of CFZ.
Nano-based theranostic approaches for infection control: current status and perspectives
Authors: Huang Regina , Hu Qin , Ko Chung-Nga , Tang Fung Kit , Xuan Shouhu , Wong Hai Ming , Jin Lijian , Li Xuan , Leung Ken Cham-Fai
Published: November 2023

Nano-based theranostic platforms constructed from various nanomaterials possess unique advantages in tackling bacterial and fungal infections while detecting pathogenic cells, making them a potential modality for addressing global healthcare burdens.
Convenient syntheses of trans-resveratrol 3-O and 4′-O-β-d-glucuronides and a study of their aqueous stability
Authors: Fraser Megan K. , Gorecka Aleksandra , Yates Edwin A. , Iggo Jonathan A. , Baj Krzysztof , Stachulski Andrew V.
Published: November 2023

The monoglucuronides of resveratrol were prepared from resveratrol triacetate. They showed contrasting properties in aqueous solution: facile E/Z isomerisation for the 3-O-isomer and ready H/D exchange, without isomerisation, for the 4′-O-isomer.
A novel LC-MS/MS method combined with derivatization for simultaneous quantification of vitamin D metabolites in human serum with diabetes as well as hyperlipidemia
Authors: Wang Xiaodi , Qin Qian , Li Fasheng , Fu Ying , Liu Na
Published: November 2023

A novel LC-MS/MS method combined with liquid–liquid extraction and derivatization was developed to analyze vitamin D metabolites and applied to the determination of the vitamin D metabolites in human serum with diabetes as well as hyperlipidemia.
The influence of silane coupling agents on the properties of α-TCP-based ceramic bone substitutes for orthopaedic applications
Authors: Pańtak Piotr , Czechowska Joanna P. , Zima Aneta
Published: November 2023

Novel, hybrid α-TCP-based bone cements containing silane coupling agents were developed and examined.
Development of a peptide-based lateral flow assay for the detection of the cancer biomarker Mdm2
Authors: Gosselin Bryan , Retout Maurice , Jabin Ivan , Bruylants Gilles
Published: November 2023

This study explores the use of peptide aptamers as effective recognition units in lateral flow assays, comparing two immobilization strategies on test line. Peptide aptamers show superior performance and ease of use compared to classical antibodies.
Amphiphilic monomers bridge hydrophobic polymers and water
Authors: Kusters Guido L. A. , Zhang Guogao , Chen Zheqi , Suo Zhigang
Published: November 2023

We mix the amphiphilic monomer acrylic acid, the hydrophobic polymer poly(methyl methacrylate), and water. We report various morphologies, which we interpret by invoking that the amphiphilic monomer can bridge the hydrophobic polymer and water.
Mechanism and preparation research of binary heteroatom co-doped (X = N, S, P) platinum/carbon black electrocatalysts for an enhanced oxygen reduction reaction via a one-pot pyrolysis method
Authors: Bai Fengning , Zhang Yantong , Hou Dongyu , Chen Jian , Meng Fanming , Leung Michael K. H. , Zhou Ling , Zhang Yingjie , Zhang Chengxu , Wang Wutao , Hu Jue
Published: November 2023

The picture vividly showcases the oxygen reduction process of single-atom doped and double-atom doped carbon supported platinum electrocatalysts.
Synthesis of stretchable hybrid copper films via nanoconfinement
Authors: Ma Xin , Xie Donghao , Wang Jiayi , Wang Zekun , Gu Qiao , Deng Yonghong , Gao Ping
Published: November 2023

A stretchable ultrastrong and ultrathin hybrid CuPE current collector is achieved through the nanoconfinement coating of copper onto UHMWPE membranes. This material results in a remarkable energy density increase of lithium-ion batteries.
The regulation effect of coordination number on the conductance of single-molecule junctions
Authors: Wan Qiang , Guo Hong-Yang , Zhou Yi-Fan , Jiang Jia-Nan , Chen Wenbo , Zheng Ju-Fang , Shao Yong , Wang Ya-Hao , Zhou Xiao-Shun
Published: November 2023

The molecules with multiple anchoring sites offer opportunities for conductance regulation of single-molecule junctions via a switch between different coordination numbers.
Field-level Lyman-α forest modeling in redshift space via augmented nonlocal Fluctuating Gunn-Peterson Approximation
Authors: Sinigaglia F. , Kitaura F.-S. , Nagamine K. , Oku Y. , Balaguera-Antolínez A.
Published: November 2023

Context. Devising fast and accurate methods of predicting the Lyman-α forest at the field level, avoiding the computational burden of running large-volume cosmological hydrodynamic simulations, is of fundamental importance to quickly generate the massive set of simulations needed by the state-of-the-art galaxy and Lyα forest spectroscopic surveys.

Aims. We present an improved analytical model to predict the Lyα forest at the field level in redshift space from the dark matter field, expanding upon the widely used Fluctuating Gunn-Peterson Approximation (FGPA). Instead of assuming a unique universal relation over the whole considered cosmic volume, we introduce a dependence on the cosmic web environment (knots, filaments, sheets, and voids) in the model, thereby effectively accounting for nonlocal bias. Furthermore, we include a detailed treatment of velocity bias in the redshift space distortion modeling, allowing the velocity bias to be cosmic-web-dependent.

Methods. We first mapped the dark matter field from real to redshift space through a particle-based relation including velocity bias, depending on the cosmic web classification of the dark matter field in real space. We then formalized an appropriate functional form for our model, building upon the traditional FGPA and including a cutoff and a boosting factor mimicking a threshold and inverse-threshold bias effect, respectively, with model parameters depending on the cosmic web classification in redshift space. Eventually, we fit the coefficients of the model via an efficient Markov chain Monte Carlo scheme.

Results. We find evidence for a significant difference between the same model parameters in different environments, suggesting that for the investigated setup the simple standard FGPA is not able to adequately predict the Lyα forest in the different cosmic web regimes. We reproduce the summary statistics of the reference cosmological hydrodynamic simulation that we use for comparison, yielding an accurate mean transmitted flux, probability distribution function, 3D power spectrum, and bispectrum. In particular, we achieve maximum deviation and average deviation accuracy in the Lyα forest 3D power spectrum of ∼3% and ∼0.1% up to k ∼ 0.4 h Mpc−1, and ∼5% and ∼1.8% up to k ∼ 1.4 h Mpc−1.

Conclusions. Our new model outperforms previous analytical efforts to predict the Lyα forest at the field level in all the probed summary statistics, and has the potential to become instrumental in the generation of fast accurate mocks for covariance matrices estimation in the context of current and forthcoming Lyα forest surveys.
Galaxy cluster mass bias from projected mass maps
Authors: Muñoz-Echeverría M. , Macías-Pérez J. F. , Artis E. , Cui W. , de Andres D. , De Luca F. , De Petris M. , Ferragamo A. , Giocoli C. , Hanser C. , Mayet F. , Meneghetti M. , Moyer-Anin A. , Paliwal A. , Perotto L. , Rasia E. , Yepes G.
Published: November 2023

The determination of the mass of galaxy clusters from observations is subject to systematic uncertainties. Beyond the errors due to instrumental and observational systematic effects, in this work we investigate the bias introduced by modelling assumptions. In particular, we consider the reconstruction of the mass of galaxy clusters from convergence maps employing spherical mass density models. We made use of THE THREE HUNDRED simulations, selecting clusters in the same redshift and mass range as the NIKA2 Sunyaev-Zel’dovich Large Programme sample: 3 ≤ M500/1014 M⊙ ≤ 10 and 0.5 ≤ z ≤ 0.9. We studied different modelling and intrinsic uncertainties that should be accounted for when using the single cluster mass estimates for scaling relations. We confirm that the orientation of clusters and the radial ranges considered for the fit have an important impact on the mass bias. The effect of the projection adds uncertainties to the order of 10–16% to the mass estimates. We also find that the scatter from cluster to cluster in the mass bias when using spherical mass models is less than 9% of the true mass of the clusters.
Detection of vibrationally excited C6H in the cold prestellar core TMC-1 with the QUIJOTE line survey
Authors: Cernicharo J. , Fuentetaja R. , Agúndez M. , Cabezas C. , Tercero B. , Marcelino N. , de Vicente P.
Published: November 2023

In this work, we present the detection of twelve doublets with quantum numbers of N = 12–11 to N = 17–16 of the ν11(μ2Σ) vibrationally excited state of C6H towards TMC-1. This marks the first time that an excited vibrational state of a molecule has been detected in a cold starless core. The data are part of the QUIJOTE line survey gathered with the Yebes 40m radio telescope. The line intensities have been aptly reproduced with a rotational temperature of 6.2 ± 0.4 K and a column density of (1.2 ± 0.2)×1011 cm−2. We also analysed the ground state transitions of C6H, detecting fourteen lines with quantum numbers of J = 23/2–21/2 to J = 35/2 for each of the two 2Π3/2 and 2Π1/2 ladders. It is not possible to model the intensities of all the transitions of the ground state simultaneously using a single column density. We considered the two ladders as two different species and found that the rotational temperature is the same for both ladders, Trot(2Π3/2)=Trot(2Π1/2)=6.2 ± 0.2, achieving a result that is comparable to that of the ν11(2μΣ) state. The derived column densities are N(2Π3/2) = (6.2 ± 0.3)×1012 cm−2 and N(2Π1/2) = (8.0 ± 0.4)×1010 cm−2. The fraction of C6H molecules in its 2Π3/2, 2Π1/2, and ν11(μ2Σ) states is 96.8%, 1.3%, and 1.9%, respectively. Finally, we report that this vibrational mode has also been detected towards the cold cores Lupus-1A and L1495B, as well as the low-mass star forming cores L1527 and L483, with fractions of C6H molecules in this mode of 3.8%, 4.1%, 14.8%, and 6%, respectively.
Operative Behandlung von Patienten mit Iliosakralgelenksyndrom: Vergleichsstudie zweier Implantate
Authors: Splitt Theresa , Pflugmacher Robert , Soliman Osama , Abd Allah Hany Mohamed , Hering Rudolf , Kasapovic Adnan , Rössler Philip , Koch Ernst M. W. , Bornemann Rahel
Published: November 2023

Die Behandlung von Patienten mit ISG-Dysfunktion ist aufgrund der multifaktoriellen Schmerzursachen und vielfältigen Probleme bei der Abklärung schwierig. Die Behandlung umfasst physikalische Therapie, Kortikosteroide, Prolotherapie, Hochfrequenzdenervation und Iliosakralgelenkfusion. Eine neue Option für die operative Behandlung von ISG-Dysfunktionen stellt das Torpedo-Implantatsystem dar. Für eine sichere Fusion werden nur 2 Implantate benötigt, die in Längen von 30–50 mm angeboten werden. Das neue Implantatsystem wurde in Pilotstudien auf Wirksamkeit und Biokompatibilität mit guten Resultaten geprüft. Zur weiteren Dokumentation für das Torpedo-Implantatsystem wurde eine Vergleichsstudie gegen das iFuse-System durchgeführt.

Es wurden 2 unterschiedliche Implantate verwendet: Gruppe 1: Deltacor Torpedo, Gruppe 2: iFuse-Implantate (Si-Bone). Die bei der Aufnahme und bei den nachfolgenden Kontrolluntersuchungen erstellten Daten (VAS, ODI, Opioidverbrauch) wurden in eine zu diesem Zweck eingerichtete Auswertungsdatei eingetragen. Als Nachuntersuchungstermine wurden 1 Monat, 3, 6 und 12 Monate postoperativ festgelegt.

Es wurden die Daten von 65 Patienten vergleichend ausgewertet. Bei allen Vergleichen zeigten sich hinsichtlich der Unterschiede im Rückgang der Schmerzintensitäten nur sehr geringe Effektstärken, sodass unter klinischen Aspekten zunächst eine gleichwertige Wirksamkeit beider Methoden postuliert werden konnte. Die meisten Patienten beider Gruppen gaben an, vor der Operation Opioide zur Schmerzbehandlung eingenommen zu haben. Entsprechend dem Rückgang der Schmerzintensität konnte bereits nach der Operation bei einigen Patienten die Opioidbehandlung abgesetzt werden. Nach 12 Monaten verringerte sich die Zahl der mit Opioiden behandelten Patienten in Gruppe 1 auf 23% und in Gruppe 2 auf 17%. Die Erfolge der Fusionen mit beiden Verfahren lassen sich zusätzlich an einer Bilddokumentation belegen, aus der auch die Lage der Implantate deutlich erkannt werden kann. In keinem Fall war eine Lockerung festzustellen.

Insgesamt lässt die Auswertung dieser Studie das Resümee zu, dass beide Implantatsysteme erfolgreich zur Behandlung von Patienten mit ISG-Syndrom eingesetzt werden können. In weiteren Vergleichsstudien mit den vorgeschlagenen Auswertungsmethoden sollten die vorliegenden Resultate überprüft werden.
Transoral incisionless fundoplication with or without hiatal hernia repair for gastroesophageal reflux disease after peroral endoscopic myotomy
Authors: DeWitt John M. , Al-Haddad Mohammad , Stainko Sarah , Perkins Anthony , Fatima Hala , Ceppa DuyKhanh P. , Birdas Thomas J.
Published: November 2023

Background and study aims Gastroesophageal reflux disease (GERD) following peroral endoscopic myotomy (POEM) occurs in 40% to 60% of patients. There are limited data evaluating antireflux surgery or transoral incisionless fundoplication (TIF) for refractory post-POEM GERD.

Patients and methods In a single-center prospective cohort study,
consecutive patients with medically refractory post-POEM regurgitation and/or GERD treated
with TIF or combined laparoscopic hernia repair and TIF (cTIF) were evaluated. Baseline
evaluation: GERD-Health Related Quality of Life (GERD-HQRL) and Reflux Symptom Questionnaire
7-day recall (RESQ-7) questionnaires, EGD, high-resolution manometry (HRM), 48-hour pH test
off proton pump inhibitors (PPIs) and impedance planimetry of the esophagogastric junction
(EGJ) to calculate the diameter distensibility index (EGJ-DI). A PPI was taken twice daily for
2 weeks after TIF and restarted later if required. Patients returned 9 to 12 months after
treatment when all preoperative studies were repeated. Quality of life, pH studies and EGJ
metrics before and after antireflux surgery were compared.

Results Seventeen patients underwent TIF (n=2, 12%) or cTIF
(n=15, 88%) a mean 25±15 months after POEM. At follow-up a mean of 9±1 months after TIF/cTIF,
patients required less frequent daily PPIs (n=0.001), were more satisfied (P=0.008), had improved GERD-HQRL (P=0.001), less intensity and frequency of GERD
(P=0.001) and fewer reflux episodes (P=0.04) by pH testing. There
was no change in EGJ-DI, EGJ diameter, integrated relaxation pressure, % total time pH <4,
or DeMeester score.

Conclusions TIF and cTIF for difficult-to-control post-POEM GERD
appear safe, decrease PPI use and reflux episodes, and improve QOL without significant change
in IRP, EGJ compliance, diameter or esophageal acid exposure time.
A Practical Synthesis of Homoallylic Diene Halides: Versatile Synthons for the Preparation of the Taxane A-Ring System
Authors: Camacho-Dávila Alejandro A. , Espinoza-Hicks José C. , Zaragoza-Galán Gerardo
Published: November 2023

A concise and efficient synthesis of two homoallylic halides, which are useful precursors for the preparation of the taxane A-ring system is reported. Contrary to the synthetic routes reported in the literature, this procedure does not employ expensive tetramethylethylene as a starting material. The synthetic route uses readily available and inexpensive ethyl acetoacetate, 1,2-dibromoethane, methyltriphenylphosphonium iodide and methylmagnesium bromide as starting materials. The key step in the synthesis is the acid-mediated ring opening of a cyclopropyl tertiary alcohol to afford the corresponding homoallylic diene halides. The corresponding Grignard reagent, derived from the bromide, is used in the synthesis of an enone previously used as a precursor of taxadienone by reaction with the enol ethyl ether of 1,3-cyclohexanedione.
Synthesis of Biomimetic Thioesters for Studies of Ketoreductase Domains from the Biosynthesis of Cytotoxic Polyketides
Authors: Hahn Frank , Derra Sebastian , Hoffmann Julian
Published: November 2023

The synthesis of biomimetic thioesters for enzymatic studies of ketoreductase (KR) domains from polyketide synthases is described. A TBS-protected dihydroxyalkene fragment was synthesised by a sequence involving a Nagao acetate aldol reaction, a Mukaiyama propionate aldol reaction, and a methylene Wittig olefination. Fragment coupling to N-acetylcysteamine (SNAC) (E)-3-hydroxyhex-4-enethioates by an olefin cross-metathesis (OCM) and subsequent deprotection gave the potential KR product stereoisomers. An analogous OCM with a SNAC (E)-3-ketohex-4-enethioate did not give the desired KR precursor, but the reaction could successfully be replaced by a Horner–Wadsworth–Emmons olefination between a SNAC 3-ketothioester phosphonate and a TBS-protected dihydroxy aldehyde. After deprotection, an intramolecular cyclisation was observed that needs to be considered as a spontaneous side reactivity in the enzymatic assays.
Organocatalytic, Chemoselective, and Stereospecific House–Meinwald Rearrangement of Trisubstituted Epoxides
Authors: Schreiner Peter R. , Dressler Friedemann , Öhler Victoria , Topp Christopher
Published: November 2023

We present a novel method for the chemoselective House–Meinwald rearrangement of trisubstituted epoxides under mild conditions with the use of simple perfluorinated disulfonimides as Brønsted acid catalysts. We isolated the α-quaternary aldehyde products in yields of 27–97% using catalyst loadings as low as 0.5 mol% on a scale of 1 mmol. In addition, we show the stereospecific rearrangement using an enantioenriched substrate, which makes this method suitable for applications in total synthesis of natural products.
The Association of Same-Day CT Scan with Postoperative Outcomes in Isolated Orbital Fracture Repair
Authors: Enin Kwasi , Pavelchek Cole , Liu Yupeng , Sciegienka Sebastian , Spataro Emily
Published: November 2023

The potential benefits to surgical outcomes of intraoperative and/or same-day computed tomography (CT) during isolated orbital fracture reconstruction are debatable, and previous research on this topic is limited by small sample size. This retrospective IBM MarketScan Commercial and Medicare Supplemental research database study examined patients undergoing isolated orbital reconstruction from January 1, 2012 to December 31, 2018, to assess whether same-day CT affected postoperative outcomes. The average age of the 5,023 participants was 37 (standard deviation [SD]: 16) years and 63% were males. The data revealed that 16.2% (815 of 5,023) patients underwent a same-day CT. Those who underwent a same-day CT scan exhibited reduced odds of postoperative enophthalmos (adjusted odds ratio [aOR]: 0.269; 95% confidence interval [CI]: 0.167–0.433) and diplopia (aOR: 0.670; 95% CI: 0.495–906). Interestingly, these patients also displayed a higher rate of revision surgeries (aOR: 2.721; 95% CI: 1.893–3.912). In summary, while same-day CT scans diminish certain postoperative complications of orbital fracture repair, they are also associated with an increased likelihood of subsequent surgical revision.
An Overview of the Methods Used to Measure the Impact of Mindfulness-Based Interventions in Sleep-Related Outcomes
Authors: Vallim Julia Ribeiro da Silva , Lima Gabriela Sant'Ana , Pires Gabriel Natan , Tufik Sergio , Demarzo Marcelo , D'Almeida Vânia
Published: November 2023

Introduction Systematic reviews and metanalyses have shown that mindfulness-based interventions can have positive effects on health, such as reducing anxiety, depression, and chronic pain. However, their effect on sleep-related outcomes is not yet well established. Sleep can be assessed subjectively (questionnaires, sleep logs, self-reporting) and/or objectively (actigraphy, polysomnography, biological markers), and outcomes may differ depending on which type of assessment is used.

Objective In this study, we present a literature overview on mindfulness and sleep, innovatively presenting and discussing studies that address sleep subjectively and objectively.

Methods The search was undertaken using four databases (Pubmed Medline, Scopus, Web of Science, Psychinfo) in September 2019, and repeated in May 2021.

Studies were analyzed through a two-step process: (1) reading titles and abstracts, and (2) full text analysis that met the review's eligibility criteria, with the final sample comprising 193 articles. We observed a growth in the number of studies published, particularly since 2005. However, this was mostly due to an increase in studies based on subjective research. There is a moderate to nonexistent agreement between objective and subjective sleep measures, with results of subjective measures having higher variability and uncertainty.We identified 151 articles (78%) using an exclusively subjective sleep evaluation, which can cause a misperception about mindfulness effects on sleep.

Conclusion Future studies should place greater emphasis on objective measurements to accurately investigate the effects of mindfulness practices on sleep, although subjective measures also have a role to play in respect of some aspects of this relationship.
2023 Guidelines on the Diagnosis and Treatment of Insomnia in Adults – Brazilian Sleep Association
Authors: Drager Luciano Ferreira , Assis Márcia , Bacelar Andrea Frota Rego , Poyares Dalva Lucia Rollemberg , Conway Silvia Gonçalves , Pires Gabriel Natan , de Azevedo Alexandre Pinto , Carissimi Alicia , Eckeli Allan Luiz , Pentagna Álvaro , Almeida Carlos Maurício Oliveira , Franco Clélia Maria Ribeiro , Sobreira Emmanuelle Silva Tavares , Stelzer Fernando Gustavo , Mendes Giuliana Macedo , Minhoto Gisele Richter , Linares Ila Marques Porto , Sousa Ksdy Maiara Moura , Gitaí Livia Leite Góes , Sukys-Claudino Lucia , Sobreira-Neto Manoel Alves , Zanini Marcio Andrei , Margis Regina , Martinez Sandra Cristina Gonçalves
Published: November 2023

Chronic insomnia disorder (simplified in this document as insomnia) is an increasingly common clinical condition in society and a frequent complaint at the offices of different areas of health practice (particularly Medicine and Psychology). This scenario has been accompanied by a significant evolution in treatment, as well as challenges in approaching patients in an appropriately way. This clinical guideline, coordinated by the Brazilian Sleep Association and the Brazilian Association of Sleep Medicine and counting on the active participation of various specialists in the area, encompasses an update on the diagnosis and treatment of insomnia in adults. To this end, it followed a structured methodology. Topics of interest related to diagnosis were written based on theoretical framework, evidence in the literature, and professional experience. As for the topics related to the treatment of insomnia, a series of questions were developed based on the PICO acronym (P – Patient, problem, or population; I – Intervention; C – Comparison, control, or comparator; O – Outcome). The work groups defined the eligible options within each of these parameters. Regarding pharmacological interventions, only the ones currently available in Brazil or possibly becoming available in the upcoming years were considered eligible. Systematic reviews were conducted to help prepare the texts and define the level of evidence for each intervention. The final result is an objective and practical document providing recommendations with the best scientific support available to professionals involved in the management of insomnia.
Preparing an Abstract for Scientific Conferences and Publications: A Beginner's Guide
Authors: Jena Anuraag , Ahuja Vivek
Published: November 2023

An abstract is a window to a research work. It describes the work in 250 to 500 words in either a structured or an unstructured format. The aim, methods, results, and conclusion are the core components. The integral aspect of writing an abstract is summarizing the entire work in limited words that not only gives away important data but also gives a clear message to its readers. In the fast-rising world of publications, abstracts are often the decisive factor in initial editorial decisions of acceptance or rejection. Good abstracts may improve citations of a work because these are often the only freely available part of the article. Graphical abstracts are becoming an integral part of submission requirements in most journals and tend to depict content figuratively. Although a book can never be judged by its cover, a well-written abstract will always draw attention to the work of the author. This article will act as guidance for writing a good abstract and familiarize readers with all components of the abstract.
Effects of 3D Airway Geometry on the Airflow of Adults with Cleft Lip and Palate and Obstructive Sleep Apnea: A Functional Imaging Study
Authors: Campos Leticia Dominguez , Trindade Inge Elly Kiemle , Trindade Sergio Henrique Kiemle , Pimenta Luiz André Freire , Kimbell Julia , Drake Amelia , Marzano-Rodrigues Maria Noel , Trindade-Suedam Ivy Kiemle
Published: November 2023

Objective Individuals with cleft lip and palate (CLP) are at a high risk of developing obstructive sleep apnea (OSA). Hypothetically, the severity of OSA might be associated with the morphology of the upper airway (UAW) and the characteristics of the airflow. Thus, the present study aimed to assess and compare, in adults with CLP and skeletal class-III discrepancy, with or without OSA, simulations of airflow resistance and pressure according to the geometrical characteristics of the UAW and cephalometric parameters.

Materials and Methods According to the results of type-I polysomnography tests, the sample (n = 21) was allocated in 2 groups: 1) without OSA (N-OSA; n = 6); and 2) with OSA (OSA; n = 15). Cephalometric measurements were performed on the cone-beam computed tomography (CBCT) scans of the groups. After three-dimensional (3D) reconstructions, the volume (V) and minimal cross-sectional area (mCSA) of the UAW were generated. Computational fluid dynamics (CFD) simulations were used to assess key airflow characteristics. The results were presented at a significance level of 5%.

Results The UAW pressure values and airway resistance did not differ between the groups, but there was a tendency for more negative pressures (26%) and greater resistance (19%) in the OSA group. Volume and mCSA showed a moderate negative correlation with resistance and pressure. The more inferior the hyoid bone, the more negative the pressures generated on the pharyngeal walls.

Conclusion The position of the hyoid bone and the geometry of the UAW (V and mCSA) exerted effects on the airway-airflow resistance and pressure. However, key airflow characteristics did not differ among subjects with CLP, were they affected or not by OSA.
Effects of Acute Sleep Deprivation on the Sequential Rate of Torque Development throughout the Force-Time Curve
Authors: Gonçalves André Dias , Pezarat-Correia Pedro , Vila-Chã Carolina , Mendonça Gonçalo Vilhena
Published: November 2023

Objective The impact of sleep deprivation on the physiological determinants of explosive torque production remains poorly understood. We aimed at determining the acute effects of 24 hours of sleep deprivation on the sequential rate of torque development (RTD) obtained during plantar flexion through maximum voluntary isometric contraction (MVIC).

Materials and Methods The study included 14 healthy-young adults (8 men and 6 women). The participants visited the laboratory on 2 different occasions: without and with 24 hours of sleep deprivation. In each session, the subjects were tested for RTD of the plantar flexors with concomitant recordings of the electromyographic (EMG) amplitude of the soleus over the following time intervals: 0 to 30, 30 to 50, 50 to 100, and 100 to 150 ms.

Results Sleep deprivation did not affect peak RTD (without sleep deprivation: 283.3 ± 111.6 N.m.s−1 versus with sleep deprivation: 294.9 ± 99.2 N.m.s−1; p > 0.05) of plantar flexion. The sequential values of RTD, as well as the normalized amplitude of the soleus EMG, remained similar between both conditions (p > 0.05).

Discussion In conclusion, we found that 24 hours of sleep deprivation do not affect muscle activation, nor explosive torque production throughout the torque-time curve. Thus, exercise performance and daily functionality in tasks involving rapid torque development might remain well preserved after 24 hours of acute sleep deprivation.
Condylar Position in the Treatment of Obstructive Sleep Apnea with a Mandibular Advancement Device: A Pilot Study
Authors: Gurgel Marcela , Kurita Lucio , Fonteles Cristiane , Ribeiro Thyciana , Costa Fabio , Freitas Benedito , Bruin Veralice , Cevidanes Lucia , Chaves-Junior Cauby
Published: November 2023

Objective To evaluate, through a tomographic analysis, the positional changes of the condyle when using a mandibular advancement device (MAD) for the treatment of obstructive sleep apnea (OSA), and to assess if the condylar positions influence OSA polysomnographic patterns.

Materials and Methods Ten OSA patients underwent treatment with an MAD, and polysomnographic and tomographic examinations were performed before therapy (T0) and after MAD placement (T1).

Results By comparing the T0 and T1 measurements, we observed advancement and extrusion of the condyles in all patients (p < 0.001), as well as a decrease in the apnea-hypopnea index (AHI) (p < 0.001), increases in the mean (p = 0.001) and minimum (p < 0.001) oxyhemoglobin saturation, and a significant correlation between the anterior displacement of the right (p = 0.003) and left (p = 0.015) condyles.

Discussion Condylar advancement was directly correlated with OSA improvement: the greater the advancement, the better the AHI.
Breakfast Eating Habits and Its Influence on Nutritional Status
Authors: Haldar Pratiti , James Alex , Negi Uma
Published: November 2023

Background Breakfast intake is considered as one of the most important factors in nutrition for adolescents, but the intake of breakfast has declined in past 25 years especially among adolescents. Breakfast not only fuels your body but also aids in carrying out whole day activities by providing the required energy.

Objectives The objectives of the study were to identify the breakfast eating and skipping patterns, identify the nutritional status, and find association between breakfast skipping and nutritional status among nursing students.

Methods To achieve this aim, a cross-sectional survey was performed among nursing students. The data related to patterns of breakfast skipping and eating was collected followed by assessment of nutritional status by checking weight and height of each student and was interpreted as per the World Health Organization criteria.

Results Out of 437 samples, a majority of 305 (69.8%) students belonged to (17–21) years of age and most of the students 409 (93.6%) were females. It was found that approximately 214 (48.97%) students were skipping breakfast three times in a week. A significant association was found between nutritional status and breakfast skipping (χ2 = 6.61, p = 0.03).

Conclusion Breakfast being first meal of the day not only provides us energy but also maintains our nutrition on everyday basis. Thereby, the study concludes that breakfast skipping affects nutritional status if skipped for more than twice in a week on a longer run. Thus, the students should be motivated to have breakfast before beginning their everyday's activity.
MA2Z4 family heterostructures: Promises and prospects
Authors: Tho Che Chen , Guo San-Dong , Liang Shi-Jun , Ong Wee Liat , Lau Chit Siong , Cao Liemao , Wang Guangzhao , Ang Yee Sin
Published: November 2023

Recent experimental synthesis of ambient-stable MoSi2N4 monolayer has garnered enormous research interest. The intercalation morphology of MoSi2N4—composed of a transition metal nitride (Mo-N) inner sub-monolayer sandwiched by two silicon nitride (Si-N) outer sub-monolayers—has motivated the computational discovery of an expansive family of synthetic MA2Z4 monolayers with no bulk (3D) material counterpart (where M = transition metals or alkaline earth metals; A = Si, Ge; and N = N, P, As). MA2Z4 monolayers exhibit interesting electronic, magnetic, optical, spintronic, valleytronic, and topological properties, making them a compelling material platform for next-generation device technologies. Furthermore, heterostructure engineering enormously expands the opportunities of MA2Z4. In this review, we summarize the recent rapid progress in the computational design of MA2Z4-based heterostructures based on first-principle density functional theory (DFT) simulations—a central work horse widely used to understand the physics, chemistry, and general design rules for specific targeted functions. We systematically classify the MA2Z4-based heterostructures based on their contact types, and review their physical properties, with a focus on their performances in electronics, optoelectronics, and energy conversion applications. We review the performance and promises of MA2Z4-based heterostructures for device applications that include electrical contacts, transistors, spintronic devices, photodetectors, solar cells, and photocatalytic water splitting. We present several prospects for the computational design of MA2Z4-based heterostructures, which hold the potential to guide the next phase of exploration, moving beyond the initial “gold rush” of MA2Z4 research. This review unveils the vast device application potential of MA2Z4-based heterostructures and paves a roadmap for the future development of MA2Z4-based functional heterostructures and devices.
Enhancing photostability of 2D Ruddlesden–Popper perovskite via molecular acceptor passivation of metallic lead defects
Authors: Kim Kitae , Kang Donghee , Blumstengel Sylke , Morales Nicolas Zorn , List-Kratochvil Emil J. W. , Cho Sang Wan , Lee Hyunbok , Park Soohyung , Yi Yeonjin
Published: November 2023

Two-dimensional (2D) Ruddlesden–Popper (RP) perovskites hold great potential for novel optoelectronic applications. However, their unconventional optoelectronic properties are often compromised by a vulnerability to light irradiation, which leads to the formation of metallic Pb (Pb0) defects. This study investigates the passivation mechanism of these Pb0 defects in phenylethylammonium lead iodide (PEA2PbI4) using a strong molecular acceptor, 2,2′-(perfluoronaphthalene-2, 6-diylidene) dimalononitrile (F6-TCNNQ). In situ x-ray photoelectron spectroscopy results demonstrate that F6-TCNNQ effectively removes the light-induced Pb0 states, leading to the recovery of photoluminescence intensity in photodegraded PEA2PbI4 samples and significantly improving the photostability of pristine PEA2PbI4. F6-TCNNQ protects the terrace edge of PEA2PbI4, which is the site of initial degradation, as evidenced by atomic force microscopy and scanning electron microscopy analyses. In situ ultraviolet photoelectron spectroscopy measurements confirm substantial electron transfer from Pb0 to F6-TCNNQ, causing the oxidation of Pb0 to Pb2+. Furthermore, the staggered energy level alignment prevents electron transfer from the valence band maximum of PEA2PbI4 to the lowest unoccupied molecular orbital of F6-TCNNQ, thereby preserving the pristine electronic structure of PEA2PbI4. These findings provide new insights into defect passivation in 2D RP perovskites and offer a design strategy for highly stable optoelectronic devices.