bluuebunny/crossref_metadata_2025 huggingface dataset:
KOMITMEN GURU BERSERTIFIKAT PENDIDIK DAN YANG BELUM BERSERTIFIKAT PENDIDIK DALAM MENINGKATKAN KOMPETENSI PROFESIONAL
Authors: Markos Markos , Anwar Syaiful
Published: June 2022

Abstrak: Tujuan dari penelitian ini adalah untuk mengetahui komitmen guru bersertifikat pendidik dan yang belum bersertifikat pendidik dalam meningkatkan kompetensi professional pada SMP Negeri 01 Pendopo Kabupaten Empat Lawang ?. dalam melaksanakan kegiatan penelitian, peneliti lebih banyak berinteraksi dan mengamati kegiatan yang dilakukan guru bersertifikat pendidik dan guru yang belum bersertifikat pendidik  pada SMP Negeri 01 pendopo dalam upaya meningkatkan kompetensi professional sekaligus membantu pemerintah dalam mencapai standar nasional pendidikan. Adapun cara pengambilan data dalam penelitian ini dengan cara observasi wawancara serta dokumentasi. Hasil penelitian tentang komitemen guru yang sudah bersertifikat pendidik dan yang belum bersertifikat pendidik dalam meningkat kompetensi profesional dalam bidang pengembangan profesi ada perbedaan sebab guru yang sudah bersertifikat pendidik ada yang telah menlanjutkan ke jenjang yang lebih tinggi ( S2) sedangkan yang belum bersertifikat pendidik belum ada yang mengikuti dengan berbagai alasan juga dalam mengikuti kegiatan workshop guru yang yang bersertifikat pendidik dengan sangat antusias mengikuti kegiatan  tersebut senangkan guru yang belum bersertifikat hanya sebagian yang mau ikut dalam kegiatan tersebut. Dalam bidang penguasan bahan kajian akademik guru baik guru yang sudah maupun yang belum bersertifikat pendidik telah menunjukan komitmen yang baik, sedangkan dalam bidang pemahaman wawasan, guru yang bersertifikat pendidik sudah ada yang sebagian  menulis artikel  ilmiah sedangkan guru yang belum bersertifikat pendidik belum sama sekali membuat walau telah beberapa kali diadakannya workshop maupun pelatihan baik yang dilakukan di sekolah dengan mengundang narasumber yang berkopenten maupun yang diadakan di kabupaten.Kata Kunci : Komitmen, guru bersertifikat pendidika dan guru yang belum bersertifikat pendidik
STRATEGI PEMBINAAN KOMPETENSI PROFESIONAL GURU
Authors: Nurbaiti Nurbaiti
Published: June 2022

Abstrak: Rumusan masalah dalam penelitian ini "Bagaimana strategi pengembangan kompetensi guru profesional di SMP Negeri 1 Pendopo Barat?" Rumus khusus dalam penelitian ini adalah 1) Bagaimana merencanakan kompetensi profesional guru di SMP 1 Negeri Pendopo Barat. 2) Bagaimana menerapkan pengembangan profesional guru di SMP Negeri 1 Pendopo Barat. 3) Bagaimana hasil yang dicapai oleh kepala sekolah dalam bimbingan kompetensi profesional guru di SMPN 1 Pendopo Barat. Hasil Coaching Kemampuan Guru Profesional di Sekolah Menengah Pertama 1 Hall West mengacu pada hasilnya, yaitu: Hasil pembinaan seorang guru baik dilakukan di tingkat Dinas Pendidikan Kabupaten Bekasi maupun tingkat cluster atau sekolah, pada dasarnya sama berakar pada kebijakan pemerintah, yaitu : Keputusan No. 16 tahun 2007 tentang standar kualifikasi akademik dan kompetensi guru. Setelah mengikuti pembinaan, motivasi mengajar guru cenderung meningkat atau setidaknya menunjukkan adanya sesuatu yang baru yang disampaikan di sekolah dan setelah mengikuti pembinaan empat kompetensi dasar guru misalnya berkaitan dengan kompetensi pedagogis guru guru yang dipelihara menunjukkan Sikap yang lebih masuk akal dalam menghadapi masalah di kelas, juga kemampuan profesional guru bisa mengantarkan materi secara optimal agar siswa bisa mengerti. Kesimpulan dari penelitian ini adalah bahwa pengembangan kapasitas profesional guru di SMP Negeri 1 Pendopo Barat telah dilakukan dengan baik dan menggunakan berbagai teknik. Kata kunci: Pengembangan profesional guru.
PELAKSANAAN SUPERVISI KLINIS
Authors: Heri Ishar Jhon , Danim Sudarwan , Anwar Syaiful
Published: June 2022

The general research objective described how principal’s management in carrying out clinical supervision. While the specific purpose of this study is  (1) to describe how the principal as a supervisor in conducting professional teacher guidance , (2) to describe collegial relations between the principal as a supervisor and the teacher in clinical supervision, (3) to describe the principal way of supervisor and the teacher solve problems together, (4) to describe how to solve the problems faced by teachers. This research use descriptive qualitative method. Subject of the research that is principal, representative of the curriculum field and subject teachers. The result of research that principal’s management in carrying out clinical supervision has been running in accordance with existing procedures. As for the conclusion of this research is (1) the principal as a supervisor before conducting supervision activities has provided guidance, (2) the implementation of clinical supervision by the principal is clone by interacting with the teacher and creating collegial relationships, (3) the principal as a supervisor to be able to solve the problems faced by teachers , (4) the solution to the problem experienced by teacher is to create a cooperative relationship with the teacher in all activities in school.
PENGELOLAAN AKREDITASI SEKOLAH MENENGAH ATAS OLEH BADAN AKREDITASI PROVINSI BENGKULU
Authors: Efendi Edi , Aliman Aliman
Published: June 2022

This qualitative study described in depth and comprehensive management of quality improvement of personnel performance in the field of manpower development in the Office of Education and Culture of Bengkulu Province. The subjects were principals, vice principals, and employees of school aministrasion. Data collection techniques used interview, observation and documentation. Data were analyzed using qualitative analysis technique. The results to ensure that every high schools in Bengkulu both state and private are managed based on national standards of education.
PENGELOLAAN PEMBELAJARAN KEBERBAKATAN CABANG TAEKWONDO
Authors: Aini Nur , Sasongko Rambat Nur
Published: June 2022

Pengelolaan Pembelajaran Keberbakatan Olahraga (Studi Deskriptif Kualitatif pada SMAN Keberbakatan Olahraga Provinsi Bengkulu: Tujuan dari penelitian ini adalah untuk mendeskripsikan bagaimana pengelolaan pembelajaran keberbakatan di Keberbakatan Olahraga Provinsi Bengkulu. Metode penelitian yang digunakan adalah deskriptif kualitatif, dan teknik pengumpulan data yang digunakan dalam penelitian ini adalah wawancara, observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa pengelolaan pembelajaran keberbakatan olahraga secara keseluruhan di lakukan sesuai dengan kebutuhan yang diperlukan, meskipun masih membutuhkan sejumlah perbaikan di dalam pengelolaan pembelajaran taekwondo itu sendiri
PENGARUH DISIPLIN KERJA TERHADAP KOMPETENSI PEDAGOGIK GURU SMK NEGERI KOTA BENGKULU
Authors: Herlina Herlina
Published: June 2022

Tujuan penelitian untuk menganalisis pengaruh disiplin kerja dan dedikasi pada kompetensi pedagogik. Metode yang digunakan adalah korelasional dengan pendekatan kuantitatif. Sampel penelitian adalah 75 guru. Teknik pengolahan data menggunakan korelasi product moment, determinasi, dan regresi. Hasil penelitian  1) disiplin kerja berpengaruh terhadap kompetensi pedagogik
EFEKTIVITAS PENGELOLAAN KEUANGAN SEKOLAH (Study Evaluativ Di SMA Negeri 7 Bengkulu Selatan)
Authors: Rekasari Meli Haryati
Published: June 2022

Tujuan penelitian secara umum untuk mengevaluasi efektivitas pengelolaan keuangan sekolah di Sekolah Menengah Atas Negeri 7 Bengkulu Selatan, sedangkan tujuan khusus untuk mengevaluasi: perencanaan, pembelanjaan, dan pertanggungjawaban keuangan sekolah. Metode penelitiannya yaitu diskriptif evaluatif. Hasil penelitan menunjukan bahwa pengelolaan keuangan di SMA Negeri 7 Bengkulu Selatan cukup efektif. Adapun kesimpulan khusus yaitu: Perencanaan keuangan sekolah sudah cukup efektif, pembelanjaan keuangan sekolah belum sesuai dengan target yang diharapkan, dan pertanggungjawaban keuangan sekolah kurang efektif.
PENGARUH KEPEMIMPINAN PARTISIPATIF TERHADAP KINERJA GURU SD NEGERI KABUPATEN KAUR
Authors: Yantoni Rasidi
Published: June 2022

Tujuan dari penelitian ini adalah untuk menganalisis pengaruh kepemimpinan partisipatif terhadap kinerja guru di SD Negeri Padang Guci Hulu, Kabupaten Kaur. Metode yang digunakan adalah korelasional dengan tipe pendekatan kuantitatif. Sampel penelitian adalah 70 guru sekolah dasar di Kabupaten Padang Guci Hulu, Kabupaten Kaur. Teknik pengolahan data menggunakan korelasi product moment, determinasi, regresi (sederhana dan berganda). Hasil penelitian tentang pengaruh kepemimpinan partisipatif secara langsung mempengaruhi kinerja guru di SD Negeri Padang Guci Hulu Kabupaten Kaur sebesar 0,382;
Pelaksanaan Sistem Penjaminan Mutu Internal (Studi Kasus : Sekolah Dasar Islam Terpadu Insan Kamil di Kabupaten Kaur)
Authors: Nengsih Ernia , Kartiwi Asti Putri
Published: June 2022

Abstrak - Penelitian ini bertujuan untuk mendeskripsikan pemetaan mutu, perencanaan mutu, pelaksanaan mutu, evaluasi mutu serta strategi peningkatan  mutu sistem penjaminan mutu internal di SDIT Insan Kamil. Penelitian ini menggunakan pendekatan deskriptif kualitatif dengan subjek penelitian adalah Kepala Sekolah, Waka Kurikulum dan Guru SDIT Insan Kamil. Teknik pengumpulan data menggunakan wawancara, observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa pemetaan mutu SDIT Insan Kamil sudah berjalan sesuai dengan tahapan sistem penjaminan mutu internal yakni mengacu pada pengisian EDS dan analisa rapor mutu, menyusun perencanaan penjaminan mutu yang berbentuk RKS dan RKT. Begitu pula dengan pelaksanaan mutu telah berjalan dengan baik sesuai rencana yang telah disusun. Evaluasi yang dilaksanakan sudah berjalan efektif dimana bentuk evaluasi mutu dilakukan oleh kepala sekolah dan struktur sekolah. Dan strategi peningkatan mutu berupa tindakan-tindakan perbaikan yang dilakukan oleh SDIT Insan Kamil.
Reliability of anti-TNF treatment in a patient with chronic lymphocytic leukemia and ankylosing spondylitis
Authors: ULUTAŞ Firdevs , ÇOBANKARA Veli , Hıncal Hande Oğul , KARASU Uğur
Published: June 2022

Anti-tumor necrosis factor alpha (anti-TNFα) agents are second-line treatment modalities for patients with ankylosing spondilitis after non-steroidal anti-inflammatory drugs, and are commonly used for different inflammatory rheumatic diseases. Development of malignancy is still one of the most feared side effects, with controversial results. In this paper, we present an ankylosing spondylitis patient with concomittant early stage chronic lymphocytic leukemia (CLL) who is currently under treatment with infliximab without progression for the past 5 years.
Vitamin C, Complex B and Hydrocortisone in Septic Patients Treated at ICU of The General Hospital 11 IMSS Piedras Negras Coahuila
Authors: de Molina Serrano Jose Ivan Rodriguez , Castro Martinez Nurse Hugo Humberto
Published: June 2022

Introduction: Sepsis is defined as severe organ disfunction as with a dysregulated response of the host with a documented or suspected infection. In Mexico sepsis represents 11,183 hospitalizations and is 27.3% of ICU admission. The Surviving Sepsis Champaign is aimed at early identification and timely treatment of these patients. Objective: Describe the difference between ICU and hospital mortality among septic patients treated with standard treatment vs standard treatment + Vitamin C + Hydrocortisone + Thiamine + Cyanocobalamin + Pyridoxine (Complex B). Material and Methods: A prospective, longitudinal, experimental cohort study was conducted in August 2019 to October 2020 ICU of the General Hospital of Zone 11 IMSS in Piedras Negras, Coahuila, conducted in 2 phases: Phase 1: control group: standard treatment accordingly GPC, duration of 6 months. Phase 2: experimental: standard treatment + treatment protocol that consist to Vitamin C 1.5 g IV every 6 hours, Hydrocortisone 50 mg IV every 6 hours and in case of v í enteral Complex B (Thiamine 100 mg Pyridoxine 5 mg Cyanocobalamin 50 mcg) 1 tablet every 6 hours for 4 consecutive days or until discharge of the patient; duration of 6 months. Results: 19 patients were enrolled for this study (12 phase 1 and 7 phase 2). The general characteristics were: Age 52.4 years, Female 31.6%, BMI 33.4, main sources of infection: Pulmonary 47.4%, Abdominal 36.8%, ICU LOS 7.0 Hospital LOS 16.3; ICU and Hospital survival 73.7%, 52.6% respectively, The only statistical difference between the two groups was steroid use and CRP. The factors associated with ICU survival were: LOS, second vasopressor use, NE dose, EPI dose, CRP, and with Hospital survival were: LOS, Hydrocortisone use, SAPS3 score, SAPS3 predicted mortality, qSOFA, SOFA, Respiratory SOFA, Renal SOFA, Hematologic SOFA, second vasopressor use, EPI dose. Vitamin C, Complex B and Hydrocortisone had no statistical significance with survival. There was no difference in organic failure and vasopressor use in both groups. Conclusion: In septic patients administration of Vitamin C, Complex B and Hydrocortisone + standard treatment vs standard treatment alone was no associated with a statistical difference in Hospital survival, organic failure or vasopresor use.
Evaluation of Inferior Mesenteric Superior Lymph Node Metastasis in Early-Stage Endometrium Cancer and Its Clinical Significance
Authors: COMERT Esra CABUK
Published: June 2022

Endometrial cancer is the fourth most common type of cancer in women cancers. In the light of projections, approximately 11,000 deaths occur annually in the USA alone. Lymph node metastasis is the most important prognostic factor in endometrial cancer. The aim of this study is to investigate the clinical and histopathological risk factors affecting lymph ode involvement. The study included 30 randomly selected women from external centers who applied to our clinic with a preliminary diagnosis of endometrial cancer and were diagnosed with endometrial cancer in our clinic. The study group was divided into two groups as stage I (early stage) and stage II and above (advanced stage) according to the stages. Total abdominal hysterectomy (Type II), bilateral salpingo-oophorectomy, paraaortic lymph node dissection from the pelvic and IMA to the level of the left renal vein, omentectomy, and peritoneal cytology sampling were performed on each of the endometrial cancer participants. The mean number of lymph node involvement in 30 patients in the study group was 45.9±15.1. The mean number of pelvic lymph nodes involved was 32.1±10.1, while the mean number of paraaortic lymph nodes involved was 13.9±6.9. As a result of the examinations, the highest number of Stage Ia was found. The frequency of endometrial adenocarcinoma was 80% and it was seen in 24 people. The mean tumor size, myometrial thickness, and depth of invasion of the patients were 2.97(±1.6), 1.57(±0.6), and 0.7(±0.6), respectively. With positive sub-IMA lymph node involvement, lymph node positivity was also detected in the area extending from the IMA to the level of the renal vein. It has been shown that the non-endomethroid tumor type detected in this group, myometrial invasion of more than 50%, grade 3 tumor and the presence of lymphovascular invasion affect lymph node involvement above the IMA.
‘Patti Smith, Bloomsbury, and the Afterlives of Modernist Objects’
Authors: Garrity Jane
Published: June 2022

This essay focuses on the photographs of Patti Smith that were shown at the Dulwich Picture Gallery's exhibition titled ‘Legacy: Photographs by Vanessa Bell and Patti Smith’ (London, February 8 to June 4, 2017). It tracks the parallel resonances between Smith and Bloomsbury with respect to ideas concerning the inseparability of materiality, emotion, and the body. The essay argues that Smith's photographs of ‘Bloomsbury objects’ convey that the immaterial can only be expressed through the material, a paradox that is key to understanding how such objects function as spiritualized relics that both highlight and supersede the dominion of the everyday.
MITIGATING CONFLICTS IN SOCIETY WITH AN UNDERSTANDING OF CIVIC EDUCATION
Authors: Subkhan Muhamad , Yatno Nono , Pudjiastuti Sri Rahayu , Kurniati Pat , Rumiati Sri
Published: June 2022

Conflict and conflict resolution in each individual is different, but the picture that must be understood is that it is different is beautiful. Actually life is an orchestra group where each player holds a different musical instrument, and each player plays his or her own role. From each of these differences will produce a beautiful harmony. Also when observing carefully how beautiful a rainbow is with all its differences, because with all the differences everything will look beautiful. A difference must be managed wisely, because difference is a necessity. The difference is beautiful, the difference is a pleasure, an extraordinary gift from Allah SWT. We can enjoy life because of a difference. Conflict in life together can be said to be something common, but conflicts that can endanger or threaten the integrity of life together cannot be ignored and ignored. Humans are social creatures, they can live, develop and play a role when dealing with and cooperating with other humans. Basically, the purpose of citizenship education is that citizenship is to be good citizens, namely citizens who have intelligence (civics intelligence), both intellectual, emotional, social, and spiritual, have a sense of pride and responsibility. (civics responsibility) and being able to participate in community life. With the aim of citizenship education, understanding citizenship is able to reduce conflict.
THE INFLUENCE OF BRAND IMAGE, PRICE, AND PRODUCT QUALITY ON PURCHASE DECISIONS (Empirical Study on Students of SMK Muhammadiyah 5 Kisaran)
Authors: Marpaung Durahman , Bakti Bakti , Saragih Liza
Published: June 2022

The purpose of the study was to analyze the effect of Brand Image, Price and Product Quality on Consumer Purchase Decisions on OPPO Smartphones, especially Students of SMK Muhammadiyah 5 Kisaran. The method used is descriptive associative with a quantitative approach. The sample used in this study amounted to 90 respondents consisting of students of SMK Muhammadiyah 5 Kisaran. The results show that Brand Image, Price and Product Quality on Purchase Decisions simultaneously have a significant effect on purchasing decisions, but partially only product quality has no significant effect on purchasing decisions..
ANALISIS STRATEGI HUBUNGAN MEDIA PT KERETA API INDONESIA DAOP 1 JAKARTA SAAT MUDIK LEBARAN 2018
Authors: Widianto Fajar , Duryatmo Sardi , Siregar Mariana Rista Ananda
Published: June 2022

The background of this research is the growth of mass media in Indonesia. Meanwhile, one of the public relations activities is responding to the interests of the media to provide information to the public. This study was conducted to analyze the media relations strategy run by PT Kereta Api Indonesia (Persero) Jakarta, in the context of Eid Mubarak Holiday 2018. The research used a qualitative method, with data sources derived from primary data and secondary data. The author uses expert triangulation to test the validity of the data obtained. This study indicated that establishing a relationship with the media is very important. Public relations and the media are two parties who need each other. Public relations requires publication from the media, while the media need information to be published as news. Keyword: eid Mubarak; Indonesia railways company; media relations; public relation
KONTROVERSI PUISI DARING DALAM POLITIK SIBER SASTRA
Authors: Gunawan Ardi Rai
Published: June 2022

ABSTRAKMunculnya teknologi daring yang memudahkan masyarakat dalam mengakses berbagai hal, membuat berbagai kalangan masyarakat memanfaatkannya untuk bermacam keperluan. Baik untuk mereproduksi pengetahuan, ataupun sekadar mengekspresikan dagelan terhadap suatu peristiwa. Budaya bersastra Indonesia menjadi salah satu dampak dari perubahan tersebut: produksi yang semula akrab dengan medium kertas pun secara berangsur berpindah haluan ke medium digital. Keinginan seseorang dalam memproduksi sastra menjadi lebih variatif. Akan tetapi, kontroversi dari kalangan kritikus sastra dan sastrawan senior membuat gaya baru dalam produksi sastra dipertanyakan, terutama masalah kualitas karya dan penulisnya. Kubu pencipta karya sastra pun terbelah dua, antara pro terhadap siber sastra dan pro terhadap keadiluhungan sastra konvensional. Melalui kajian kepustakaan, penulis menyorot fenomena tersebut dengan menganalisis beberapa karya puisi daring, yang dewasa ini banyak pula ditulis oleh sastrawan yang telah lama menulis karya sastra konvensional. Tujuannya untuk merelevansi dua karakter karya penyair tersebut.    Kata kunci: Siber sastra,  demokrasi sastra, kontroversi sastrawan, poltik sastra
STRUKTUR, KONTEKS, DAN FUNGSI CERITA RAKYAT KARANGKAMULYAN
Authors: Merdiyatna Yang Yang
Published: June 2022

ABSTRAKPenelitian ini dilatarbelakangi keingintahuan peneliti terhadap cerita rakyat. Peneliti mengkaji cerita rakyat yang berada di daerah Karangkamulyan Kabupaten Ciamis. Penelitian ini bertujuan mengkaji dari aspek struktur, konteks, dan fungsi. Penelitian ini pun mendeskripsikan tokoh atau sosok yang muncul dari cerita, konteks, dan fungsinya. Hasil deskripsi tersebut memunculkan tokoh yang patut dijadikan panutan atau pelajaran bagi generasi muda sekarang. Penelitian ini menggunakan metode deskriptif analisis. Hasil kajian struktur menunjukkan fakta cerita tentang tokoh karuhun atau leluhur, putra mahkota kerjaaan, serta tokoh lainnya yang pantas untuk menjadi teladan. Tokoh tersebut mencerminkan leluhur bangsa pada umumnya dan Sunda pada khususnya yang sangat visioner dan sangat memperhatikan kepentingan bersama. Hasil kajian konteks menunjukkan cerita memiliki konteks dalam penuturan. Hasil kajian fungsi menunjukkan adanya fungsi tertentu terhadap masyarakat. Dengan demikian, kajian terhadap cerita rakyat di daerah Karangkamulyan ini menunjukkan adanya karakter tokoh yang pantas dijadikan teladan, konteks cerita dengan daerah Karangkamulyan yang memiliki keterkaitan, dan fungsi yang memiliki pengaruh terhadap masyarakat. Kata Kunci: Cerita Rakyat, Struktur, Konteks, dan Fungsi.
ANALISIS INTERTEKSTUAL KARAKTER DEWI UMA DI DALAM PUISI “U.M.A.” KARYA PUTU FAJAR ARCANA
Authors: Fitriarti Karunia , Monica Isye Mountana
Published: June 2022

ABSTRAKPemahaman puisi tidak dapat dilepaskan dari latar belakang kemasyarakatan dan budayanya. Begitu pula dengan puisi yang memiliki latar belakang pewayangan, seperti puisi “U.M.A.” karya Putu Fajar Arcana yang terinspirasi dari kisah Sudamala. Dengan menggunakan teori resepsi sastra, teori interteks, serta beberapa pendekatan, penulis dapat menyimpulkan jika karakter Dewi Uma, yang terdapat di dalam puisi ini ternyata memiliki korelasi dengan perempuan-perempuan yang ada di Indonesia, terutama dalam perspektif gender. Segala jenis perbuatan, tingkah laku, sampai takdirnya ditentukan oleh seorang laki-laki.Penelitian ini menggunakan metode kualitatif, sehingga data-data yang terkumpul dianalisis secara deskriptif kualitatif sehingga diketahui gambaran karakter yang terkait yang dianalisis.  Kata Kunci: gender, Putu Fajar Arcana, U.M.A.
METAFORA DALAM NOVEL LASKAR PELANGI KARYA ANDREA HIRATA (ANALISIS STILITIKA)
Authors: Ganiwati Wiwik Srini
Published: June 2022

ABSTRAKPenelitian ini bertujuan untuk memperoleh pemahaman tentang metafora yang terdapat dalam novel Laskar Pelangi karya Andrea Hirata. Penelitian ini menggunakan metode kualitatif deskriptif dengan teknik analisis isi. Data penelitian ini  adalah metafora yang terdapat dalam novel Laskar Pelangi karya Andrea Hirata. Hasil penelitian menunjukkan bahwa dalam novel Laskar Pelangi karya Andrea Hirata, ditemukan 76 kalimat yang mengandung metafora dan 87 metafora yang terdapat dalam kalimat: (1) analisis metafora berdasarkan sumbernya  menurut Kovecses terdiri dari 9 metafora dari sumber tubuh manusia, 6 metafora dari sumber binatang, 10 metafora dari sumber tanaman, 2 metafora dari sumber pembangunan, 1 metafora dari sumber permainan dan olah raga, 3 metafora dari sumber uang dan transaksi ekonomi, 18 metafora dari sumber cahaya dan kegelapan, 17 metafora dari sumber kekuatan, 23 metafora dari sumber arah dan gerakan. Sedangkan, (2) metafora berdasarkan maknanya menurut Murray Knowles dan Rosamund Moon terdiri dari 76 kalimat yang mengandung metafora, 82 kata yang mengandung makna literal dan 86 metafora yang mengandung makna non-literal. Selanjutnya, 3) metafora berdasarkan fungsinya menurut F.R. Ankersmit dan J.J. A. Mooij terdiri dari 76 kalimat yang mengandung metafora, 37 metafora yang memiliki fungsi emotif, 5 metafora memiliki fungsi persuasif dan 44 metafora memiliki fungsi kognitif.Kata kunci: Andrea Hirata; Laskar Pelangi; metafora; stilistika.
PENDIDIKAN GENDER BAGI ANAK DI PERKAMPUNGAN TAMBA DOLOK MELALUI PELESTARIAN KISAH BATU MAROMPA DALAM BENTUK DONGENG
Authors: Manalu Sry Ayu Magdalena , Sinuhaji Nopaldi Stepen , Sari Sartika
Published: June 2022

Penelitian ini bertujuan untuk menguak norma perkawinan yang berkembang di masyarakat Batak melalui cerita Batu Marompa. Metode yang digunakan adalah metode penelitian kualitatif dengan pendekatan deskriptif. Untuk mengamati secara mendalam mengenai konsep pernikahan yang berkembang, penelitian ini menggunakan kerangka kajian gender. Dapat disimpulkan bahwasanya cerita ini mengajarkan kita sebagai orangtua agar lebih memperhatikan psikis anak. Kita juga harus mengingat adat istiadat yang ada pada suku kita, terkhususnya pada masyarakat batak. Adat istiadat suku batak mengajarkan untuk tidak menjalin hubungan semarga ataupun sedarah. Dengan adanya hasil penelitian ini, penulis berharap semoga peneliti lainnya dapat mengangkat kembali kisah legenda yang berada di sekitarnya dengan memanfaatkan berbagai media yang dapat menarik minat pembaca terkhususnya anak-anak ataupun remaja. Kata Kunci: Pendidikan Gender; Kisah; Dongeng.
ASPEK MORAL SEBAGAI LANDASAN PERUBAHAN DARI NOVEL RONGGENG DUKUH PARUK KE DALAM FILM SANG PENARI
Authors: Hidayati Ika Titi
Published: June 2022

Tujuan tulisan ini akan mengulas mengenain Aspek Moral Sebagai Landasan Perubahan dari Novel Ronggeng Dukuh Paruk ke dalam Film Sang Penari. Penelitian ini menggunakan metode kualitatif. Teknik pengumpulan data dalam penelitian ini menggunakan teknik catat, yaitu mencatat temuan-temuan data yang dijadikan model analisis data. Aspek moral dalam masyarakat menjadi unsur penting sebagai suatu tatanan norma yang mengatur kehidupan masyarakat. Peraturan atau prinsip moral sebagai ketetapan akal budi manusia selalu berlaku di mana-mana dan menjadi prasyarat untuk menggolongkan dan menilai apakah suatu tindakan bisa disebut tindakan moral atau tidak. Penilaian moral tak mungkin dilakukan lepas dari peraturan atau prinsip moral di mana satu tindakan tertentu bisa digolongkan. Kata Kunci: Moral; Norma; Sang Penari; Ronggeng Dukuh Paruk.
Latest Trends in Lateral Flow Immunoassay (LFIA) Detection Labels and Conjugation Process
Authors: Mirica Andreea-Cristina , Stan Dana , Chelcea Ioana-Cristina , Mihailescu Carmen Marinela , Ofiteru Augustin , Bocancia-Mateescu Lorena-Andreea
Published: June 2022

LFIA is one of the most successful analytical methods for various target molecules detection. As a recent example, LFIA tests have played an important role in mitigating the effects of the global pandemic with SARS-COV-2, due to their ability to rapidly detect infected individuals and stop further spreading of the virus. For this reason, researchers around the world have done tremendous efforts to improve their sensibility and specificity. The development of LFIA has many sensitive steps, but some of the most important ones are choosing the proper labeling probes, the functionalization method and the conjugation process. There are a series of labeling probes described in the specialized literature, such as gold nanoparticles (GNP), latex particles (LP), magnetic nanoparticles (MNP), quantum dots (QDs) and more recently carbon, silica and europium nanoparticles. The current review aims to present some of the most recent and promising methods for the functionalization of the labeling probes and the conjugation with biomolecules, such as antibodies and antigens. The last chapter is dedicated to a selection of conjugation protocols, applicable to various types of nanoparticles (GNPs, QDs, magnetic nanoparticles, carbon nanoparticles, silica and europium nanoparticles).
Transcriptomic Analysis of Mature Transgenic Poplar Expressing the Transcription Factor JERF36 Gene in Two Different Environments
Authors: Zhang Weixi , Wang Yanbo , Zhang Tengqian , Zhang Jing , Shen Le , Zhang Bingyu , Ding Changjun , Su Xiaohua
Published: June 2022

During the last several decades, a number of transgenic or genetically modified tree varieties with enhanced characteristics and new traits have been produced. These trees have become associated with generally unsubstantiated concerns over health and environmental safety. We conducted transcriptome sequencing of transgenic Populus alba × P. berolinensis expressing the transcription factor JERF36 gene (ABJ01) and the non-transgenic progenitor line (9#) to compare the transcriptional changes in the apical buds. We found that 0.77% and 1.31% of the total expressed genes were significant differentially expressed in ABJ01 at the Daqing and Qiqihar sites, respectively. Among them, 30%–50% of the DEGs contained cis-elements recognized by JERF36. Approximately 5% of the total number of expressed genes showed significant differential expression between Daqing and Qiqihar in both ABJ01 and 9#. 10 DEGs resulting from foreign gene introduction, 394 DEGs that resulted solely from the environmental differences, and 47 DEGs that resulted from the combination of foreign gene introduction and the environment were identified. The number of DEGs resulting from environmental factors was significantly greater than that resulting from foreign gene introduction, and the combined effect of the environmental effects with foreign gene introduction was significantly greater than resulting from the introduction of JERF36 alone. GO and KEGG annotation showed that the DEGs mainly participate in the photosynthesis, oxidative phosphorylation, plant hormone signaling, ribosome, endocytosis, and plant-pathogen interaction pathways, which play important roles in the responses to biotic and abiotic stresses ins plant. To enhance its adaptability to salt-alkali stress, the transgenic poplar line may regulate the expression of genes that participate in the photosynthesis, oxidative phosphorylation, MAPK, and plant hormone signaling pathways. The crosstalk between biotic and abiotic stress responses by plant hormones may improve the ability of both transgenic and non-transgenic poplars to defend against pathogens. The results of our study provide a basis for further studies on the molecular mechanisms behind improved stress resistance and the unexpected effects of transgenic gene expression in poplars, which will be significant for improving the biosafety evaluation of transgenic trees and accelerating the breeding of new varieties of forest trees resistant to environmental stresses.
Synthesis, Antibacterial and Insecticidal Activities of Novel Capsaicin Derivatives Containing a Sulfonic Acid Esters Moiety
Authors: Xie Dandan , Yang Zaiping , Hu Xin , Wen Yin
Published: June 2022

In order to develop an efficient and broad-spectrum bactericide, a series of novel capsaicin derivatives containing a sulfonic acid esters moiety was synthesized. The structure of these compounds were confirmed by nuclear magnetic resonance spectroscopy (NMR) and high-resolution mass spectrum (HRMS). The results of the bioactivities revealed that some target compounds exhibited remarkable antibacterial activity. Compound 3b exhibited the highest activities against Pseudomonas syringae pv. actinidiae (Psa), Xanthomonas oryzae pv. oryzae (Xoo), and Xanthomonas axonopodis pv. citri (Xac), and the values were 86, 54, and 92% at 50 μg/ml, respectively, which were higher than were for thiodiazole copper (87, 34, and 77%) and bismerthiazol (87, 37 and 75%). Although some compounds also showed certain activity against Spodoptera frugiperda, it was weaker than the positive controls monosultap and mulfoxaflor. Thus, the bioassay results recommend that these newly designed and synthesized scaffolds should be used as a bactericide lead compound rather than an insecticide lead compound.
Flame Retardancy Properties and Rheological Behavior of PP/DiDOPO Conjugated Flame Retardant Composites
Authors: Zhang Daohai , Shang Xiaoyu , Luo Jiyong , Sun Junzhuo , Tan Fang , Bao Dongmei , Qin Shuhao
Published: June 2022

A bridged 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide derivative (DiDOPO) with conjugated structure was utilized as a novel conjugated flame retardant, Polypropylene(PP)/DiDOPO conjugated flame retardant composites were papered by being melt-extruding with a twin-screw extruder. The flame retardant efficiency of PP/DiDOPO conjugated flame retardant composites were investigated by cone calorimetry, limiting oxygen index (LOI), vertical burning test (UL-94). Besides, the rheological behavior of PP/DiDOPO conjugated flame retardant composites are measured by ARES rheometer. The results showed that when the content of DiDOPO with conjugated structure was 16 wt%, the LOI values of PP/DiDOPO conjugated flame retardant composites was 24%, and PP/DiDOPO conjugated flame retardant composites reaches V-0 grade. The heat release rate (HRR), total heat release rate (THR) and CO2 of PP/DiDOPO conjugated flame retardant composites decreased, so PP/DiDOPO conjugated flame retardant composites had excellent flame retardant effect. Rheological analysis results indicated that DiDOPO with conjugated structure suppressed the melt dripping of PP/DiDOPO conjugated flame retardant composites by enhancing the melt stability. The results showed that the DiDOPO with conjugated structure can significantly enhance the flame retardancy effect of PP/DiDOPO conjugated flame retardant composites. In addition, the materials PP/DiDOPO might be with low conductivity and charge transport mobility.
Intestinal Microbial Composition of Children in a Randomized Controlled Trial of Probiotics to Treat Acute Gastroenteritis
Authors: Horne Rachael G. , Freedman Stephen B. , Johnson-Henry Kathene C. , Pang Xiao-Li , Lee Bonita E. , Farion Ken J. , Gouin Serge , Schuh Suzanne , Poonai Naveen , Hurley Katrina F. , Finkelstein Yaron , Xie Jianling , Williamson-Urquhart Sarah , Chui Linda , Rossi Laura , Surette Michael G. , Sherman Philip M.
Published: June 2022

Compositional analysis of the intestinal microbiome in pre-schoolers is understudied. Effects of probiotics on the gut microbiota were evaluated in children under 4-years-old presenting to an emergency department with acute gastroenteritis. Included were 70 study participants (n=32 placebo, n=38 probiotics) with stool specimens at baseline (day 0), day 5, and after a washout period (day 28). Microbiota composition and deduced functions were profiled using 16S ribosomal RNA sequencing and predictive metagenomics, respectively. Probiotics were detected at day 5 of administration but otherwise had no discernable effects, whereas detection of bacterial infection (P<0.001) and participant age (P<0.001) had the largest effects on microbiota composition, microbial diversity, and deduced bacterial functions. Participants under 1 year had lower bacterial diversity than older aged pre-schoolers; compositional changes of individual bacterial taxa were associated with maturation of the gut microbiota. Advances in age were associated with differences in gut microbiota composition and deduced microbial functions, which have the potential to impact health later in life.

Clinical Trial Registration

www.ClinicalTrials.gov, identifier: NCT01853124.
Application of Next-Generation Sequencing in Infections After Allogeneic Haematopoietic Stem Cell Transplantation: A Retrospective Study
Authors: Zhang Xiaoying , Li Yun , Yin Jin , Xi Bixin , Wang Na , Zhang Yicheng
Published: June 2022

This retrospective study aimed to determine the characteristics of infection and diagnostic efficacy of next-generation sequencing (NGS) in patients with fever after allogeneic hematopoietic stem cell transplantation (allo-HSCT). A total of 71 patients with fever after HSCT were enrolled in this study. Compared with conventional microbiological test (CMT), we found that the sensitivity of NGS versus CMT in peripheral blood samples was 91.2% vs. 41.2%, and that NGS required significantly less time to identify the pathogens in both monomicrobial infections (P=0.0185) and polymicrobial infections (P= 0.0027). The diagnostic performance of NGS was not affected by immunosuppressant use. Viruses are the most common pathogens associated with infections. These results indicated that the sensitivity, timeliness, and clinical significance of NGS are superior for the detection of infections. Although NGS has the advantage of identifying a wide range of potential pathogens, the positive rate is related closely to the sample type. Therefore, we recommend that, in the clinical application of NGS to detect pathogens in patients after allo-HSCT, an appropriate sample type and time should be selected and submitted to improve the positive rate and accuracy of NGS. NGS holds promise as a powerful technology for the diagnosis of fever after HSCT.
Different Antiplatelet Strategies for Radial Artery Protection After Transradial Coronary Angiography—A Prospective Observational Cohort Study
Authors: Qin Zheng , Yang Xingsheng , Cheng Wanjun , Wang Jianlong , Jin Zening
Published: June 2022

Introduction

Radial artery occlusion (RAO) after transradial access is a common thrombotic complication. A meta-analysis has proven that RAO incidence in transradial coronary angiography (TRCA) settings was significantly higher than that in percutaneous coronary intervention settings. This prospective observational cohort aimed to evaluate radial artery protection after TRCA with different antiplatelet strategies.

Methods

A total of 2,316 patients undergoing TRCA was enrolled and divided into two groups: single-antiplatelet and dual-antiplatelet groups. Radial artery patency was evaluated by ultrasound before, at 24 h, and 30 days after TRCA. The primary endpoint was RAO incidence at 30 days after TRCA.

Results

A total of 66 RAO was found on ultrasonography at 30-day follow-up (incidence: 2.8%). In the dual-antiplatelet group, the rate of RAO was significantly lower compared with the single-antiplatelet group (1.8 vs. 4.0%; odds ratio (OR): 0.41; 95% confidence interval (CI): 0.24–0.70; p = 0.001). The rate of self-recanalization in the dual-antiplatelet group was significantly higher than that in the single-antiplatelet group (73.68 vs. 44.12%, p < 0.001). However, there was no statistical difference in delayed occlusion of radial artery between the two groups (0.5 vs. 0.2%, p = 0.140). Unexpectedly, this study also showed no significant difference in bleeding risk between the groups.

Conclusion

Dual-antiplatelet therapy for 1 month after TRCA was associated with a reduced risk of RAO and deemed safe.
Exocytosis Proteins: Typical and Atypical Mechanisms of Action in Skeletal Muscle
Authors: Hwang Jinhee , Thurmond Debbie C.
Published: June 2022

Insulin-stimulated glucose uptake in skeletal muscle is of fundamental importance to prevent postprandial hyperglycemia, and long-term deficits in insulin-stimulated glucose uptake underlie insulin resistance and type 2 diabetes. Skeletal muscle is responsible for ~80% of the peripheral glucose uptake from circulation via the insulin-responsive glucose transporter GLUT4. GLUT4 is mainly sequestered in intracellular GLUT4 storage vesicles in the basal state. In response to insulin, the GLUT4 storage vesicles rapidly translocate to the plasma membrane, where they undergo vesicle docking, priming, and fusion via the high-affinity interactions among the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) exocytosis proteins and their regulators. Numerous studies have elucidated that GLUT4 translocation is defective in insulin resistance and type 2 diabetes. Emerging evidence also links defects in several SNAREs and SNARE regulatory proteins to insulin resistance and type 2 diabetes in rodents and humans. Therefore, we highlight the latest research on the role of SNAREs and their regulatory proteins in insulin-stimulated GLUT4 translocation in skeletal muscle. Subsequently, we discuss the novel emerging role of SNARE proteins as interaction partners in pathways not typically thought to involve SNAREs and how these atypical functions reveal novel therapeutic targets for combating peripheral insulin resistance and diabetes.
Identification of QTNs Associated With Flowering Time, Maturity, and Plant Height Traits in Linum usitatissimum L. Using Genome-Wide Association Study
Authors: Saroha Ankit , Pal Deepa , Gomashe Sunil S. , Akash  , Kaur Vikender , Ujjainwal Shraddha , Rajkumar S. , Aravind J. , Radhamani J. , Kumar Rajesh , Chand Dinesh , Sengupta Abhishek , Wankhede Dhammaprakash Pandhari
Published: June 2022

Early flowering, maturity, and plant height are important traits for linseed to fit in rice fallows, for rainfed agriculture, and for economically viable cultivation. Here, Multi-Locus Genome-Wide Association Study (ML-GWAS) was undertaken in an association mapping panel of 131 accessions, genotyped using 68,925 SNPs identified by genotyping by sequencing approach. Phenotypic evaluation data of five environments comprising 3 years and two locations were used. GWAS was performed for three flowering time traits including days to 5%, 50%, and 95% flowering, days to maturity, and plant height by employing five ML-GWAS methods: FASTmrEMMA, FASTmrMLM, ISIS EM-BLASSO, mrMLM, and pLARmEB. A total of 335 unique QTNs have been identified for five traits across five environments. 109 QTNs were stable as observed in ≥2 methods and/or environments, explaining up to 36.6% phenotypic variance. For three flowering time traits, days to maturity, and plant height, 53, 30, and 27 stable QTNs, respectively, were identified. Candidate genes having roles in flower, pollen, embryo, seed and fruit development, and xylem/phloem histogenesis have been identified. Gene expression of candidate genes for flowering and plant height were studied using transcriptome of an early maturing variety Sharda (IC0523807). The present study unravels QTNs/candidate genes underlying complex flowering, days to maturity, and plant height traits in linseed.
Risk Factors for Weak Antibody Response of SARS-CoV-2 Vaccine in Adult Solid Organ Transplant Recipients: A Systemic Review and Meta-Analysis
Authors: Zong Kezhen , Peng Dadi , Yang Hang , Huang Zuotian , Luo Yunhai , Wang Yihua , Xiang Song , Li Tingting , Mou Tong , Wu Zhongjun
Published: June 2022

Objective

This is the first systematic review and meta-analysis to determine the factors that contribute to poor antibody response in organ transplant recipients after receiving the 2-dose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine.

Method

Data was obtained from Embase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Chinese Biomedical Literature Database (CBM). Studies reporting factors associated with antibody responses to the 2-dose SARS-CoV-2 vaccine in solid organ transplant recipients were included in our study based on the inclusion and exclusion criteria. Two researchers completed the literature search, screening, and data extraction. Randomized models were used to obtain results. Egger’s test was performed to determine publication bias. Sensitivity analysis was performed to determine the stability of the result. The heterogeneity was determined using the Galbraith plot and subgroup analysis.

Results

A total of 29 studies were included in the present study. The factors included living donor, BNT162b2, tacrolimus, cyclosporine, antimetabolite, mycophenolic acid (MPA) or mycophenolate mofetil (MMF), azathioprine, corticosteroids, high-dose corticosteroids, belatacept, mammalian target of rapamycin (mTOR) inhibitor, tritherapy, age, estimated glomerular filtration rate (eGFR), hemoglobin, and tacrolimus level were significantly different. Multivariate analysis showed significant differences in age, diabetes mellitus, MPA or MMF, high-dose corticosteroids, tritherapy, and eGFR.

Conclusion

The possible independent risk factors for negative antibody response in patients with organ transplants who received the 2-dose SARS-CoV-2 vaccine include age, diabetes mellitus, low eGFR, MPA or MMF, high-dose corticosteroids, and triple immunosuppression therapy. mTOR inhibitor can be a protective factor against weak antibody response.

Systematic Review Registration

PROSPERO, identifier CRD42021257965.
RG100204, A Novel Aquaporin-9 Inhibitor, Reduces Septic Cardiomyopathy and Multiple Organ Failure in Murine Sepsis
Authors: Mohammad Shireen , O’Riordan Caroline E. , Verra Chiara , Aimaretti Eleonora , Alves Gustavo Ferreira , Dreisch Klaus , Evenäs Johan , Gena Patrizia , Tesse Angela , Rützler Michael , Collino Massimo , Calamita Giuseppe , Thiemermann Christoph
Published: June 2022

Sepsis is caused by systemic infection and is a major health concern as it is the primary cause of death from infection. It is the leading cause of mortality worldwide and there are no specific effective treatments for sepsis. Gene deletion of the neutral solute channel Aquaporin 9 (AQP9) normalizes oxidative stress and improves survival in a bacterial endotoxin induced mouse model of sepsis. In this study we described the initial characterization and effects of a novel small molecule AQP9 inhibitor, RG100204, in a cecal ligation and puncture (CLP) induced model of polymicrobial infection. In vitro, RG100204 blocked mouse AQP9 H2O2 permeability in an ectopic CHO cell expression system and abolished the LPS induced increase in superoxide anion and nitric oxide in FaO hepatoma cells. Pre-treatment of CLP-mice with RG100204 (25 mg/kg p.o. before CLP and then again at 8 h after CLP) attenuated the hypothermia, cardiac dysfunction (systolic and diastolic), renal dysfunction and hepatocellular injury caused by CLP-induced sepsis. Post-treatment of CLP-mice with RG100204 also attenuated the cardiac dysfunction (systolic and diastolic), the renal dysfunction caused by CLP-induced sepsis, but did not significantly reduce the liver injury or hypothermia. The most striking finding was that oral administration of RG100204 as late as 3 h after the onset of polymicrobial sepsis attenuated the cardiac and renal dysfunction caused by severe sepsis. Immunoblot quantification demonstrated that RG100204 reduced activation of the NLRP3 inflammasome pathway. Moreover, myeloperoxidase activity in RG100204 treated lung tissue was reduced. Together these results indicate that AQP9 may be a novel drug target in polymicrobial sepsis.