bluuebunny/crossref_metadata_2025 huggingface dataset:
A COLAB Model of Workplace Transformation in the Criminal Justice Context
Authors: Hean Sarah , Aakjær Marie , Kloetzer Laure , Seppänen Laura , Kajamaa Anu , Lahtinen Päivikki , Murphy Tine
Published: August 2021

This chapter presents the COLAB model for promoting organisational learning and innovation with potential application in criminal justice-related organisations. We describe this model as a toolkit that built on the Change Laboratory model of workplace transformation but one augmented with the beneficial components of Activity Clinics, Boundary Crossing Workshops and Codesign methods and developed within the criminal justice context. Limitations and future directions for the model are discussed.
Should Nano-Particles be Weighed or Counted? Technical Considerations to In Vitro Testing Originated from Corpuscular Nature of Nano-Particles
Authors: Kałas Wojciech
Published: August 2021

The abundance of nanoparticles introduced to household products created the great expectations towards the application of nanotechnology in biology and medicine. That calls for cost-effective preliminary assessment of its cytotoxicity and biological activity. There are many attempts for creating proper guidance and standards for performing studies regarding nanoparticles. But still some important aspects crucial for in vitro testing of nanomaterials need more attention. Particulate nature is an obvious and widely unappreciated property of nanoparticles. In the context of in vitro studies, this property is critical, and it should be, but rarely is, considered when designing, performing, describing or interpreting the experiments involving the solid nanoparticles. First, we should be aware of relatively small and limited number of nanoparticles in the experimental setup. Even crude estimation of its number will be useful for proper interpretation of results. Second, we should not presume even distribution of particles in the solution, moreover we should expect that sedimentation and aggregation play an important role in interactions of nanoparticles with cells. In that case, expressing the dose in mass/volume units may lead as astray. Finally, the relation of size, weight, and number of nanoparticles makes comparisons of activity of nanoparticles of different sizes very complex. Estimations of number of nanoparticles in the dose should be an integral part of experiment design, its validation and interpretation.
Low-dose radiotherapy for painful osteoarthritis of the elderly: A multicenter analysis of 970 patients with 1185 treated sites
Authors: Rühle Alexander , Tkotsch Elisabeth , Mravlag Rainer , Haehl Erik , Spohn Simon K. B. , Zamboglou Constantinos , Huber Peter E. , Debus Jürgen , Grosu Anca-Ligia , Sprave Tanja , Nicolay Nils H.
Published: August 2021

Purpose

Painful osteoarthritis is common in elderly patients, and low-dose radiotherapy has been demonstrated to provide effective symptomatic treatment. We examined the analgesic effects of low-dose radiotherapy for osteoarthritis in the elderly aiming to reveal potential differences in the response rates relating to increasing age.

Methods

A retrospective analysis was performed at two university hospitals including elderly patients (≥ 65 years) undergoing radiotherapy for osteoarthritis between 2008 and 2020. Pain intensity and response were quantified using the numerical rating scale (NRS) and the Pannewitz score. Age groups were defined for young old (65–74 years), older old (75–84 years), and oldest old patients (≥ 85 years).

Results

In all, 970 patients with 1185 treated sites and a median age of 76 years were analyzed. Mean NRS was 66 at baseline (t0), 53 after radiotherapy (t1), and 44 at first follow-up (t2) (p < 0.001 for t0–t1, t1–t2, and t0–t2). At t1, 1.5% exhibited a Pannewitz score of 0 (no pain), 58.5% of 1–2 (less pain), 36.1% of 3 (equal pain), and 3.9% of 4 (worse pain), while at t2, pain response shifted towards 6.9% (0), 58.6% (1–2), 28.1% (3), and 6.3% (4). Pain response did not differ between age groups at t1 (p = 0.172) or t2 (p = 0.684). In addition, pain response after re-irradiation (n = 384 sites) was 61.0% and was comparable between age groups (p = 0.535).

Conclusion

Low-dose radiotherapy results in pain reduction in about two-thirds of treated sites with no difference relating to increasing age, showing that radiotherapy is an effective analgesic treatment for osteoarthritis even at advanced ages.
Diagnostics of infrapatellar saphenous neuralgia—a reversible cause of chronic anteromedial pain following knee surgery
Authors: Yang Schu-Ren , Hirschmann Michael T. , Schiffmann Alain , Kovacs Balazs K. , Gehweiler Julian , Amsler Felix , Hirschmann Anna
Published: August 2021

Objectives

To evaluate the impact of diagnostic nerve block and ultrasound findings on therapeutic choices and predict the outcome after concomitant surgery in patients with suspected neuropathy of the infrapatellar branch of the saphenous nerve (IPBSN).

Methods

Fifty-five patients following knee surgery with suspicion of IPBSN neuralgia were retrospectively included. Ultrasound reports were assessed for neuroma and postsurgical scarring (yes/no). Responders and non-responders were assigned following anesthetic injection of the IPBSN. The type of procedure (neurectomy/interventional pain procedure/other than nerve-associated therapy) and pain score at initial follow-up were recorded and patients were assigned as positive (full pain relief) or negative (partial/no pain relief) to therapeutic nerve treatment. Factors associated with a relevant visual analog scale (VAS) reduction were assessed using uni- and multivariate logistic regression models and chi-square for quantitative and qualitative variables (p ≤ 0.05).

Results

Responders (37/55) more often had an entrapment or an evident neuroma of the IPBSN (97% vs. 6%). A positive Hoffmann-Tinel sign (p = 0.002) and the absence of knee joint instability (p = 0.029) predicted a positive response of the diagnostic nerve block (90%; 26/29). In the follow-up after therapeutic nerve treatment, all patients with full pain relief showed neuromas or entrapment of the IPBSN. Patients negatively responding to therapeutic nerve treatment more frequently showed an additional knee joint instability (25% vs. 4%).

Conclusion

Selective denervation for neuropathic knee pain is beneficial in selected patients with significant VAS reduction after diagnostic nerve block. Non-responders following diagnostic nerve block but sonographic evidence of IPBSN pathologies need to be evaluated for other causes such as knee joint instability.

Key Points

• Sonographic diagnosis of neuroma or entrapment of the IPBSN is frequently seen in patients with anteromedial knee pain and leads to a good response to diagnostic nerve block following knee surgery.

• The vast majority of patients with clinical signs of IPBSN neuropathy and response to a diagnostic nerve block sustained full pain relief following therapeutic nerve treatment.

• Patients not responding to therapeutic IPBSN treatment have to be evaluated for other causes of anteromedial knee pain such as knee joint instability.
Population genetic structure of a major reef-building coral species Acropora downingi in northeastern Arabian Peninsula
Authors: Torquato Felipe , Bouwmeester Jessica , Range Pedro , Marshell Alyssa , Priest Mark A. , Burt John A. , Møller Peter R. , Ben-Hamadou Radhouan
Published: August 2021

Current seawater temperatures around the northeastern Arabian Peninsula resemble future global forecasts as temperatures > 35 °C are commonly observed in summer. To provide a more fundamental aim of understanding the structure of wild populations in extreme environmental conditions, we conducted a population genetic study of a widespread, regional endemic table coral species,Acropora downingi, across the northeastern Arabian Peninsula. A total of 63 samples were collected in the southern Arabian/Persian Gulf (Abu Dhabi and Qatar) and the Sea of Oman (northeastern Oman). Using RAD-seq techniques, we described the population structure ofA. downingiacross the study area. Pairwise G’st and distance-based analyses using neutral markers displayed two distinct genetic clusters: one represented by Arabian/Persian Gulf individuals, and the other by Sea of Oman individuals. Nevertheless, a model-based method applied to the genetic data suggested a panmictic population encompassing both seas. Hypotheses to explain the distinctiveness of phylogeographic subregions in the northeastern Arabian Peninsula rely on either (1) bottleneck events due to successive mass coral bleaching, (2) recent founder effect, (3) ecological speciation due to the large spatial gradients in physical conditions, or (4) the combination of seascape features, ocean circulation and larval traits. Neutral markers indicated a slightly structured population ofA. downingi,which exclude the ecological speciation hypothesis.Future studies across a broader range of organisms are required to furnish evidence for existing hypotheses explaining a population structure observed in the study area. Though this is the most thermally tolerant acroporid species worldwide,A. downingicorals in the Arabian/Persian Gulf have undergone major mortality events over the past three decades. Therefore, the present genetic study has important implications for understanding patterns and processes of differentiation in this group, whose populations may be pushed to extinction as the Arabian/Persian Gulf warms.
Prognostic factors in adult brainstem glioma: a tertiary care center analysis and review of the literature
Authors: Leibetseder Annette , Leitner Johannes , Mair Maximilian J. , Meckel Stephan , Hainfellner Johannes A. , Aichholzer Martin , Widhalm Georg , Dieckmann Karin , Weis Serge , Furtner Julia , von Oertzen Tim , Preusser Matthias , Pichler Josef , Berghoff Anna Sophie
Published: August 2021

Introduction

Adult brainstem gliomas (BSGs) are rare central nervous system tumours characterized by a highly heterogeneous clinical course. Median survival times range from 11 to 84 months. Beyond surgery, no treatment standard has been established. We investigated clinical and radiological data to assess prognostic features providing support for treatment decisions.

Methods

34 BSG patients treated between 2000 and 2019 and aged ≥ 18 years at the time of diagnosis were retrospectively identified from the databases of the two largest Austrian Neuro-Oncology centres. Clinical data including baseline characteristics, clinical disease course, applied therapies, the outcome as well as neuroradiological and neuropathological findings were gathered and analysed. The tumour apparent diffusion coefficient (ADC), volumetry of contrast-enhancing and non-contrast-enhancing lesions were determined on magnetic resonance imaging scans performed at diagnosis.

Results

The median age at diagnosis was 38.5 years (range 18–71 years). Tumour progression occurred in 26/34 (76.5%) patients after a median follow up time of 19 months (range 0.9–236.2). Median overall survival (OS) and progression-free survival (PFS) was 24.1 months (range 0.9–236.2; 95% CI 18.1–30.1) and 14.5 months (range 0.7–178.5; 95% CI 5.1–23.9), respectively. Low-performance status, high body mass index (BMI) at diagnosis and WHO grading were associated with shorter PFS and OS at univariate analysis (p < 0.05, log rank test, respectively). ADC values below the median were significantly associated with shorter OS (14.9 vs 44.2 months, p = 0.018).

Conclusion

ECOG, BMI, WHO grade and ADC values were associated with the survival prognosis of BSG patients and should be included in the prognostic assessment.
Optic nerve injury in preoperative imaging is associated with visual improvement outcome in endoscopic optic nerve decompression
Authors: Leitner Isabella , Andrianakis Alexandros , Gellner Verena , Kiss Peter , Andrianakis Damianos , Tomazic Peter Valentin
Published: August 2021

Objective

To evaluate potential clinical parameters having an impact on visual outcome after endoscopic optic nerve decompression in acute optic neuropathy patients.

Methods

A retrospective chart review of patients with acute optic neuropathy, who underwent endoscopic optic nerve decompression between June 2001 and November 2018 at an academic center was performed. Patients were divided into groups according to visual improvement after surgical treatment (yes/no). Following clinical parameters were compared between groups: perioperative steroid use, evidence of optic nerve affection in preoperative neuroimaging, additional optic nerve sheath incision, surgery delay and preoperative C-reactive protein (CRP) levels. Further subgroups analyses were conducted based on etiology (trauma/tumor).

Results

Among 32 included cases, 16 patients (50%) reported visual improvement after endoscopic optic nerve decompression. There was no significant difference in visual improvement between etiology subgroups (trauma: n = 9/20 (45%) vs. tumor: n = 7/12 (58.3%), p = 0.465). Tumor subgroup patients with visual improvement had a significantly higher prevalence of optic nerve affection in preoperative neuroimaging than those without visual improvement (p = 0.018, φ = 0.683). Perioperative steroid administration was negatively associated with visual outcome (p = 0.034, φ = 0.375). Nerve sheath incision, surgery delay and preoperative CRP levels did not have a significant impact on visual outcome (p > 0.05).

Conclusion

Radiological findings can help as an indicator for surgical treatment since an affected optic nerve in preoperative neuroimaging resulted in better visual outcome after surgery. The use of steroids should be considered more carefully since it did not show any beneficial effect.
Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse
Authors: Maletzko Antonia , Key Jana , Wittig Ilka , Gispert Suzana , Koepf Gabriele , Canet-Pons Júlia , Torres-Odio Sylvia , West A. Phillip , Auburger Georg
Published: August 2021

Mitochondrial dysfunction may activate innate immunity, e.g. upon abnormal handling of mitochondrial DNA in TFAM mutants or in altered mitophagy. Recent reports showed that also deletion of mitochondrial matrix peptidase ClpP in mice triggers transcriptional upregulation of inflammatory factors. Here, we studied ClpP-null mouse brain at two ages and mouse embryonal fibroblasts, to identify which signaling pathways are responsible, employing mass spectrometry, subcellular fractionation, immunoblots, and reverse transcriptase polymerase chain reaction. Several mitochondrial unfolded protein response factors showed accumulation and altered migration in blue-native gels, prominently the co-chaperone DNAJA3. Its mitochondrial dysregulation increased also its extra-mitochondrial abundance in the nucleus, a relevant observation given that DNAJA3 modulates innate immunity. Similar observations were made for STAT1, a putative DNAJA3 interactor. Elevated expression was observed not only for the transcription factorsStat1/2, but also for two interferon-stimulated genes (Ifi44,Gbp3). Inflammatory responses were strongest for the RLR pattern recognition receptors (Ddx58,Ifih1,Oasl2,Trim25) and several cytosolic nucleic acid sensors (Ifit1,Ifit3,Oas1b,Ifi204,Mnda). The consistent dysregulation of these factors from an early age might influence also human Perrault syndrome, where ClpP loss-of-function leads to early infertility and deafness, with subsequent widespread neurodegeneration.
Neutrophil extracellular traps and neutrophil-derived mediators as possible biomarkers in bronchial asthma
Authors: Varricchi Gilda , Modestino Luca , Poto Remo , Cristinziano Leonardo , Gentile Luca , Postiglione Loredana , Spadaro Giuseppe , Galdiero Maria Rosaria
Published: August 2021

Neutrophils (PMNs) contain and release a powerful arsenal of mediators, including several granular enzymes, reactive oxygen species (ROS) and neutrophil extracellular traps (NETs). Although airway neutrophilia is associated with severity, poor response to glucocorticoids and exacerbations, the pathophysiological role of neutrophils in asthma remains poorly understood. Twenty-four patients with asthma and 22 healthy controls (HCs) were prospectively recruited. Highly purified peripheral blood neutrophils (> 99%) were evaluated for ROS production and activation status upon stimulation with lipopolysaccharide (LPS), N-formylmethionyl-leucyl-phenylalanine (fMLP) and phorbol 12-myristate 13-acetate (PMA). Plasma levels of myeloperoxidase (MPO), CXCL8, matrix metalloproteinase-9 (MMP-9), granulocyte–monocyte colony-stimulating factor (GM-CSF) and vascular endothelial growth factor (VEGF-A) were measured by ELISA. Plasma concentrations of citrullinated histone H3 (CitH3) and circulating free DNA (dsDNA) were evaluated as NET biomarkers. Activated PMNs from asthmatics displayed reduced ROS production and activation status compared to HCs. Plasma levels of MPO, MMP-9 and CXCL8 were increased in asthmatics compared to HCs. CitH3 and dsDNA plasma levels were increased in asthmatics compared to controls and the CitH3 concentrations were inversely correlated to the % decrease in FEV1/FVC in asthmatics. These findings indicate that neutrophils and their mediators could have an active role in asthma pathophysiology.
Fast simulation of railway bridge dynamics accounting for soil–structure interaction
Authors: Galvín P. , Romero A. , Moliner E. , Connolly D. P. , Martínez-Rodrigo M. D.
Published: August 2021

A novel numerical methodology is presented to solve the dynamic response of railway bridges under the passage of running trains, considering soil–structure interaction. It is advantageous compared to alternative approaches because it permits, (i) consideration of complex geometries for the bridge and foundations, (ii) simulation of stratified soils, and, (iii) solving the train-bridge dynamic problem at minimal computational cost. The approach uses sub-structuring to split the problem into two coupled interaction problems: the soil–foundation, and the soil–foundation–bridge systems. In the former, the foundation and surrounding soil are discretized with Finite Elements (FE), and padded with Perfectly Match Layers to avoid boundary reflections. Considering this domain, the equivalent frequency dependent dynamic stiffness and damping characteristics of the soil–foundation system are computed. For the second sub-system, the dynamic response of the structure under railway traffic is computed using a FE model with spring and dashpot elements at the support locations, which have the equivalent properties determined using the first sub-system. This soil–foundation–bridge model is solved using complex modal superposition, considering the equivalent dynamic stiffness and damping of the soil–foundation corresponding to each natural frequency. The proposed approach is then validated using both experimental measurements and an alternative Finite Element–Boundary Element (FE–BE) methodology. A strong match is found and the results discussed.
Exceedance of design actions in epicentral areas: insights from the ShakeMap envelopes for the 2016–2017 central Italy sequence
Authors: Iervolino Iunio , Cito Pasquale , Felicetta Chiara , Lanzano Giovanni , Vitale Antonio
Published: August 2021

ShakeMap is the tool to evaluate the ground motion effect of earthquakes in vast areas. It is useful to delimit the zones where the shaking is expected to have been most significant, for civil defense rapid response. From the earthquake engineering point of view, it can be used to infer the seismic actions on the built environment to calibrate vulnerability models or to define the reconstruction policies based on observed damage vs shaking. In the case of long-lasting seismic sequences, it can be useful to develop ShakeMap envelopes, that is, maps of the largest ground intensity among those from the ShakeMap of (selected) events of a seismic sequence, to delimit areas where the effects of the whole sequence have been of structural engineering relevance. This study introduces ShakeMap envelopes and discusses them for the central Italy 2016–2017 seismic sequence. The specific goals of the study are: (i) to compare the envelopes and the ShakeMap of the main events of the sequence to make the case for sequence-based maps; (ii) to quantify the exceedance of design seismic actions based on the envelopes; (iii) to make envelopes available for further studies and the reconstruction planning; (iv) to gather insights on the (repeated) exceedance of design seismic actions at some sites. Results, which include considerations of uncertainty in ShakeMap, show that the sequence caused exceedance of design hazard in thousands of square kilometers. The most relevant effects of the sequence are, as expected, due to the mainshock, yet seismic actions larger than those enforced by the code for structural design are found also around the epicenters of the smaller magnitude events. At some locations, the succession of ground-shaking that has excited structures, provides insights on structural damage accumulation that has likely taken place; something that is not accounted for explicitly in modern seismic design. The envelopes developed are available as supplemental material.
FK506-binding protein 2 (FKBP13) inhibit Bax-induced apoptosis in Saccharomyces cerevisiae (yeast)
Authors: Akintade Damilare D. , Chaudhuri Bhabatosh
Published: August 2021

FK506-binding protein 2 (FKBP13) is a part of the immunophilin protein family involved in immunoregulation. It is also believed to operate as a factor in membrane cytoskeletal framework and as an ER chaperone. FKBP2 (FKBP13) and FKBP1 (FKBP12), known as immunophilins, are binding proteins for rapamycin and FK506, which are immunosuppressive drugs. It was suggested that immunophilin-like and immunophilin proteins play significant roles in regulating intracellular calcium and protein folding/sorting, acting as molecular chaperones. Within the 15 mammalian FKBPs known, FKBP1 is merely the only one proven to form complexes with rapamycin and FK506 in the cytosol and facilitate their T cells immunosuppressive effects, FKBP2 is a luminal protein of the endoplasmic reticulum (ER) and is reported to take part in protein folding in the ER. However, little is known about FKBP2 link with apoptosis (either as a pro or anti-apoptotic protein). In this study, FKPB2 protein was co-expressed with the pro-apoptotic protein Bax after a yeast-based human hippocampal cDNA library screening. The yeast strain carrying the Bax gene was transformed with an episomal 2-micron plasmid that encodes the HA-tagged FKBP2 gene. The resultant strain would allow co-expression of Bax and FKBP2 in yeast cells. The results presented here show that a protein involved in protein folding can play a role in protecting yeast cell from Bax-induced apoptosis.
Gig qualifications for the gig economy: micro-credentials and the ‘hungry mile’
Authors: Wheelahan Leesa , Moodie Gavin
Published: August 2021

This paper argues that micro-credentials are gig credentials for the gig economy. Micro-credentials are short competency-based industry-aligned units of learning, while the gig economy comprises contingent work by individual ‘suppliers’. Both can be facilitated by (often the same) digital platforms, and both are underpinned by social relations of precariousness in the labour market and in society. They are mutually reinforcing and each has the potential to amplify the other. Rather than presenting new opportunities for social inclusion and access to education, they contribute to the privatisation of education by unbundling the curriculum and blurring the line between public and private provision in higher education. They accelerate the transfer of the costs of employment preparation, induction, and progression from governments and employers to individuals. Micro-credentials contribute to ‘disciplining’ higher education in two ways: first by building tighter links between higher education and workplace requirements (rather than whole occupations), and through ensuring universities are more ‘responsive’ to employer demands in a competitive market crowded with other types of providers. Instead of micro-credentials, progressive, democratic societies should seek to ensure that all members of society have access to a meaningful qualification that has value in the labour market and in society more broadly, and as a bridge to further education. This is a broader vision of education in which the purpose of education is to prepare individuals to live lives they have reason to value, and not just in the specifics required of particular jobs.
Global mapping of 10-day differences of temperature and salinity in the intermediate layer observed with Argo floats
Authors: Kawai Yoshimi , Hosoda Shigeki
Published: August 2021

The authors examine small-scale spatiotemporal variability of the layer nearly 2000-m depth, which is the “bottom” of the present Argo observation system, using all of available Argo float data. The 10-day change, ΔT10, is defined as the difference of temperature between two successive observations with an interval of nearly 10 days for each individual float at an isobaric surface. |ΔT10| is large along the western boundary currents at 1000 dbar, and becomes less remarkable with depth. At 1950 dbar, mean |ΔT10| is noticeable in the northeastern Atlantic Ocean (NEAO), the Argentine basin, and the northwestern Indian Ocean. In the Southern Ocean, large |ΔT10| is localized in some areas located over the ridges or leeward of the plateau. Basically, ΔT10 at isobaric surfaces is accounted for by the heave component, but the spiciness component is dominant or comparable to the other in the NEAO and the Argentine basin. ΔT10 decreases with depth monotonically most of the world, suggesting that wind energy input is attenuated with depth. In some areas in the Southern Ocean, however, the vertical profile of |ΔT10| implies enhanced bottom-induced turbulence. |ΔT10| peaks at 1300 dbar in the NEAO, corresponding to the spread of the Mediterranean Outflow Water. |ΔT10| is smaller in the Pacific Ocean compared with the other oceans, but is enhanced along the equator, the Kuroshio and its Extension, the Kuril, Aleutian, Hawaii, and Mariana Islands, and the Emperor Seamount Chain.
Associations Between Self-reported Inhibitory Control, Stress, and Alcohol (Mis)use During the First Wave of the COVID-19 Pandemic in the UK: a National Cross-sectional Study Utilising Data From Four Birth Cohorts
Authors: Clay James M. , Stafford Lorenzo D. , Parker Matthew O.
Published: August 2021

We explored (1) self-reported changes in alcohol use during the pandemic in the UK and (2) the extent to which self-reported inhibitory control and/or stress were associated with any change in drinking behaviour. We used a UK-based cross-sectional online survey administered to four nationally representative birth cohorts (N = 13,453). A significant minority of 30- (29.08%) and 50-year-olds (26.67%) reported drinking more, and between 32.23 and 45.02% of respondents reported feeling more stressed depending on the cohort. Stress was associated with hazardous drinking among 30-year-olds (OR = 3.77, 95% CI 1.15 to 12.28). Impatience was associated with both increased alcohol use (1.14, 95% CI 1.06, 1.24) and hazardous drinking (1.20, 95% CI 1.05, 1.38) among 19-year-olds. Risk-taking was associated with hazardous drinking for 30-year-olds (OR = 1.18, 95% CI 1.05, 1.32). These data highlight concerns for those at risk of alcohol misuse and alcohol-related harm during COVID-19 lockdowns.
Safe by Design for Nanomaterials—Late Lessons from Early Warnings for Sustainable Innovation
Authors: Brennan Maurice Edward , Valsami-Jones Eugenia
Published: August 2021

The Safe by Design conceptual initiative being developed for nanomaterials offers a template for a new sustainable innovation approach for advanced materials with four important sustainability characteristics. Firstly, it requires potential toxicity risks to be evaluated earlier in the innovation cycle simultaneously with its chemical functionality and possible commercial applications. Secondly, it offers future options for reducing animal laboratory testing by early assessment using in silico predictive toxicological approaches, minimizing the number that reaches in vitro and in vivo trials. Thirdly, it promotes a culture of shared responsibility for ethical and sustainable outcomes in the innovation process by promoting early dialogue between groups with vested interests. Finally, it offers the prospect of a more democratized innovation process by including civil society actors in decisions on product safety, commercial applications, and social utility. Collectively, these four characteristics offer the prospect for a new social contract between science, technology, and society for the societal alignment and sustainable innovation of advanced materials.
Mit Sicherheit zu etwas Neuem: Zur Bedeutung psychologischer Sicherheit in der Post-Merger-Integration (PMI)
Authors: Pfurr Alexander , Schirrmacher Freimut
Published: August 2021

Zahlreiche Unternehmensfusionen in Deutschland scheitern oder bleiben weit hinter den Erwartungen zurück. Besondere Bedeutung für das Gelingen von Fusionen hat die Gestaltung der Post-Merger-Integration, also die Phase des Zusammenführens der beiden vormals selbstständigen Unternehmen. Das von Amy C. Edmondson entwickelte Konzept der psychologischen Sicherheit könnte hierfür eine wichtige Funktion zur Orientierung und Handlungsleitung erhalten. Die erste Auswertung von Ergebnissen einer qualitativen Befragung von acht Post-Merger erfahrenen Beratungspersonen zeigt, dass dieses Konzept in Deutschland bislang noch nicht explizit eingesetzt wurde, aber dazu dienen kann, dass Firmenfusionen erfolgreicher abschließen. Interventionen und Maßnahmen, die hierbei zum Einsatz kommen können, sind gegenüber einer rein betriebswirtschaftlichen Denkart komplexer und machen die Begleitung durch externe Prozessberatende sinnvoll.
Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels?
Authors: Cicero Arrigo F. G. , Fogacci Federica , Stoian Anca Pantea , Vrablik Michal , Al Rasadi Khalid , Banach Maciej , Toth Peter P. , Rizzo Manfredi
Published: August 2021

Purpose of Review

The aim of this review is to summarize the available clinical efficacy and safety data related to the most studied and used lipid-lowering nutraceuticals.

Recent Findings

A growing number of meta-analyses of randomized clinical trials supports the effectiveness and tolerability of some lipid-lowering nutraceuticals such as red yeast rice, plant sterols and stanols, soluble fibers, berberine, artichoke extracts, bergamot polyphenol fraction, garlic, green tea, and spiruline. No significant safety concern has been raised for the use of such products. Association of more lipid-lowering nutraceuticals and of some nutraceuticals with lipid-lowering drugs has been tested as well.

Current evidence suggests that some clinically tested lipid-lowering nutraceuticals could be safely used to improve plasma lipid levels in subjects affected by mild-to-moderate dyslipidaemia with low cardiovascular risk.
Effect of Oxidative Stress on Bone Remodeling in Periprosthetic Osteolysis
Authors: Galliera Emanuela , Massaccesi Luca , Banfi Giuseppe , De Vecchi Elena , Ragone Vincenza , Corsi Romanelli Massimiliano M.
Published: August 2021

The success of implant performance and arthroplasty is based on several factors, including oxidative stress-induced osteolysis. Oxidative stress is a key factor of the inflammatory response. Implant biomaterials can release wear particles which may elicit adverse reactions in patients, such as local inflammatory response leading to tissue damage, which eventually results in loosening of the implant. Wear debris undergo phagocytosis by macrophages, inducing a low-grade chronic inflammation and reactive oxygen species (ROS) production. In addition, ROS can also be directly produced by prosthetic biomaterial oxidation. Overall, ROS amplify the inflammatory response and stimulate both RANKL-induced osteoclastogenesis and osteoblast apoptosis, resulting in bone resorption, leading to periprosthetic osteolysis. Therefore, a growing understanding of the mechanism of oxidative stress-induced periprosthetic osteolysis and anti-oxidant strategies of implant design as well as the addition of anti-oxidant agents will help to improve implants’ performances and therapeutic approaches.
Participation by national parliaments in the EU legislative process
Authors: Cygan Adam
Published: August 2021

Europeanisation has marginalised national parliaments and their democratic practices leading to a ‘de-parliamentarisation’ within the EU. The Treaty of Lisbon included substantive provisions designed to improve participation by national parliaments in EU decision-making, the most significant of which is the allocation of subsidiarity monitoring. This was intended to address concerns that national parliaments are peripheral within the EU Polity, and that EU legislation lacks legitimacy amongst its citizens. Protocols 1 and 2 of the Treaty of Lisbon promote a horizontal political dialogue between national parliaments within subsidiarity monitoring, but, experience of the last ten year indicates that this has not improved legislative legitimacy, nor adequately addressed de-parliamentarisation. This article argues that, while the Treaty of Lisbon has enhanced the privileges of national parliaments, they have not been ‘re-centred’ as an influential collective bloc of actors within the EU’s institutional framework.
“My Last Husband and Marriage:” The Impact of Inheritance Disputes on Chinese Immigrants’ Widowhood in the United States
Authors: Shi Hua
Published: August 2021

This study explores the unique experiences of the emotional processing of the widowhood of individuals of the Chinese seniors, and immigrant background in the United States. By interviewing eight Chinese immigrant widows living in Phoenix, the United States, this study focuses on the comparison of social relations and lifestyles before and after their spousal loss, as well as the unique forces of their Chinese backgrounds and the transnational remarriages in their bereavement process, and then widow status. The narrative accounts of the participants therein illustrate that transnational marriage and blended families generate a series of practical challenges, including unexpected severed friendships and inheritance disputes between stepmother and stepchildren. The consequences are reflected in the increase of self-loathing and low self-esteem, the refusal to remarry, the rising anger at the betrayal of friends, as well as the rapid formation of a high level of independence and self-determination in such circumstances. These findings increase knowledge of widowhood of Chinese women with immigrant background, therein enrich ethno-cultural diversity in the widowhood studies.This study concludes with the implications of providing bilingual legal aid and counseling to Chinese-origin, US-based, and widows.
A novel density peaks clustering algorithm based on K nearest neighbors with adaptive merging strategy
Authors: Yuan Xiaoning , Yu Hang , Liang Jun , Xu Bing
Published: August 2021

Recently the density peaks clustering algorithm (DPC) has received a lot of attention from researchers. The DPC algorithm is able to find cluster centers and complete clustering tasks quickly. It is also suitable for different kinds of clustering tasks. However, deciding the cutoff distance $${d}_{c}$$

d
c

largely depends on human experience which greatly affects clustering results. In addition, the selection of cluster centers requires manual participation which affects the efficiency of the algorithm. In order to solve these problems, we propose a density peaks clustering algorithm based on K nearest neighbors with adaptive merging strategy (KNN-ADPC). A clusters merging strategy is proposed to automatically aggregate over-segmented clusters. Additionally, the K nearest neighbors are adopted to divide data points more reasonably. There is only one parameter in KNN-ADPC algorithm, and the clustering task can be conducted automatically without human involvement. The experiment results on artificial and real-world datasets prove higher accuracy of KNN-ADPC compared with DBSCAN, K-means++, DPC, and DPC-KNN.
An update on image forming methods: structure analysis and Gestalt evaluation of images from rocket lettuce with shading, N supply, organic or mineral fertilization, and biodynamic preparations
Authors: Athmann Miriam , Bornhütter Roya , Busscher Nicolaas , Doesburg Paul , Geier Uwe , Mergardt Gaby , Scherr Claudia , Köpke Ulrich , Fritz Jürgen
Published: August 2021

In the image forming methods, copper chloride crystallization (CCCryst), capillary dynamolysis (CapDyn), and circular chromatography (CChrom), characteristic patterns emerge in response to different food extracts. These patterns reflect the resistance to decomposition as an aspect of resilience and are therefore used in product quality assessment complementary to chemical analyses. In the presented study, rocket lettuce from a field trial with different radiation intensities, nitrogen supply, biodynamic, organic and mineral fertilization, and with or without horn silica application was investigated with all three image forming methods. The main objective was to compare two different evaluation approaches, differing in the type of image forming method leading the evaluation, the amount of factors analyzed, and the deployed perceptual strategy: Firstly, image evaluation of samples from all four experimental factors simultaneously by two individual evaluators was based mainly on analyzing structural features in CapDyn (analytical perception). Secondly, a panel of eight evaluators applied a Gestalt evaluation imbued with a kinesthetic engagement of CCCryst patterns from either fertilization treatments or horn silica treatments, followed by a confirmatory analysis of individual structural features. With the analytical approach, samples from different radiation intensities and N supply levels were identified correctly in two out of two sample sets with groups of five samples per treatment each (Cohen’s kappa, p = 0.0079), and the two organic fertilizer treatments were differentiated from the mineral fertilizer treatment in eight out of eight sample sets with groups of three manure and two minerally fertilized samples each (Cohen’s kappa, p = 0.0048). With the panel approach based on Gestalt evaluation, biodynamic fertilization was differentiated from organic and mineral fertilization in two out of two exams with 16 comparisons each (Friedman test, p < 0.001), and samples with horn silica application were successfully identified in two out of two exams with 32 comparisons each (Friedman test, p < 0.001). Further research will show which properties of the food decisive for resistance to decomposition are reflected by analytical and Gestalt criteria, respectively, in CCCryst and CapDyn images.
Behaviour of the Monotone Single Index Model Under Repeated Measurements
Authors: Balabdaoui Fadoua , Durot Cécile , Jankowski Hanna
Published: August 2021

The generalized linear model is an important method in the statistical toolkit. The isotonic single index model can be thought of as a further generalization whereby the link function is assumed to be monotone non-decreasing as opposed to known and fixed. Such a shape constraint is quite natural in many statistical problems, and is fulfilled by the usual generalized linear models. In this paper we consider inference in this model in the setting where repeated measurements of predictor values and associated responses are observed. This setting is encountered in medical studies and is very different from the one considered in the classical monotone single index model studied in the literature. Here, we use nonparametric maximum likelihood estimation to infer the unknown regression vector and link function. We present a detailed study of finite and asymptotic properties of this estimator and propose goodness-of-fit tests for the model. Through an extended simulation study, we show that the model has competitive predictive performance. We illustrate our estimation approach using a Leukemia data set.
Development and Psychometric Properties of an Instrument for the Assessment of Assertiveness in Sexual Relations
Authors: Gil-Llario María Dolores , Fernández-García Olga , Gil-Juliá Beatriz , Estruch-García Verónica , Ballester-Arnal Rafael
Published: August 2021

Introduction

The potential consequences of being assertive or non-assertive for people’s sexual health and sexual well-being highlight the importance of assessing sexual assertiveness (SA). The currently available measures have limitations because they do not take recent social changes into account, they are designed to only assess women, and/or they ignore several components of SA. This study tests the psychometric properties of the Assertiveness in Sexual Relations Questionnaire (ASRQ).

Methods

Thus, 2370 participants (aged 18–69 years) of Spain completed the ASRQ, along with other scales that assesses related dimensions (e.g., family values in relation to sexual assertiveness, sexual esteem). Data were collected during 2020.

Results

Exploratory factor analysis yielded a four-factor structure: Assertive behavior as initiative, sub-assertive behavior, overly assertive behavior as initiative, and assertive behavior as a response, which was verified by confirmatory factor analysis (CFA). A multigroup CFA was also conducted in men and women, confirming the adequacy of this four-factor structure across genders. The reliability of the factors ranged from 0.72 to 0.87. Similarly, correlations with related scales were mostly significant and in the expected direction.

Conclusions

The psychometric results obtained support the use of the ASRQ as a reliable and valid measure to assess sexual assertiveness in both men and women.

Policy Implications

The availability of an instrument to assess sexual assertiveness, whose psychometric properties have been satisfactorily tested, benefits society by contributing to the improvement of the sexual health of the population, allowing for more effective interventions and the early detection of skills that contribute to the establishment of risky sexual interactions.
Progress in nuclear astrophysics of east and southeast Asia
Authors: Aziz Azni Abdul , Ahmad Nor Sofiah , Ahn S. , Aoki Wako , Bhuyan Muruthujaya , Chen Ke-Jung , Guo Gang , Hahn K. I. , Kajino Toshitaka , Kassim Hasan Abu , Kim D. , Kubono Shigeru , Kusakabe Motohiko , Li A. , Li Haining , Li Z. H. , Liu W. P. , Liu Z. W. , Motobayashi Tohru , Pan Kuo-Chuan , Park T.-S. , Shi Jian-Rong , Tang Xiaodong , Wang W. , Wen Liangjian , Wu Meng-Ru , Yan Hong-Liang , Yusof Norhasliza
Published: August 2021

Nuclear astrophysics is an interdisciplinary research field of nuclear physics and astrophysics, seeking for the answer to a question, how to understand the evolution of the universe with the nuclear processes which we learn. We review the research activities of nuclear astrophysics in east and southeast Asia which includes astronomy, experimental and theoretical nuclear physics, and astrophysics. Several hot topics such as the Li problems, critical nuclear reactions and properties in stars, properties of dense matter, r-process nucleosynthesis, andν-process nucleosynthesis are chosen and discussed in further details. Some future Asian facilities, together with physics perspectives, are introduced.
Sexual Dysfunction in Patients With Chronic Gastrointestinal and Liver Diseases: A neglected Issue
Authors: Romano Lorenzo , Granata Lucia , Fusco Ferdinando , Napolitano Luigi , Cerbone Rosa , Priadko Kateryna , Sciorio Carmine , Mirone Vincenzo , Romano Marco
Published: August 2021

Introduction

Normal sexual activity is an important determinant of quality of life. Unfortunately, several chronic health disorders are associated with an impaired sexual function.

Objective

To provide coverage of the current literature on prevalence and pathophysiology of sexual dysfunction in patients with gastrointestinal and liver disorders

Methods

A Comprehensive review of the literature on the prevalence of sexual dysfunction in chronic gastrointestinal and liver disorders, assessing the underlying mechanism (s) was performed.

Results

Many gastrointestinal disorders, either functional or organic, are associated with some degree of sexual dysfunction. The main pathogenic mechanisms are: (i) the disease itself causing fatigue, anxiety or depression with a potential alteration of self-esteem; (ii) worry of transmitting a potential infectious agent through sexual activity; (iii) alteration of the endocrine mechanisms which are necessary for normal sexual functioning; (iv) chronic pro- inflammatory conditions which may cause endothelial dysfunction and abnormal vascular responses; (v) iatrogenic.

Conclusion

Based on this review, a thorough evaluation of sexual function through validated questionnaires and/or psychological interviews with patients with chronic gastrointestinal disorders should be part of the clinical assessment in order to timely diagnose and possibly treat sexual dysfunction in this clinical setting.
Suitability of Google Trends™ for Digital Surveillance During Ongoing COVID-19 Epidemic: A Case Study from India
Authors: Satpathy Parmeshwar , Kumar Sanjeev , Prasad Pankaj
Published: August 2021

Objective:

Digital surveillance has shown mixed results as a supplement to traditional surveillance. Google Trends™ (GT) (Google, Mountain View, CA, United States) has been used for digital surveillance of H1N1, Ebola and MERS. We used GT to correlate the information seeking on COVID-19 with number of tests and cases in India.

Methods:

Data was obtained on daily tests and cases from WHO, ECDC and covid19india.org. We used a comprehensive search strategy to retrieve GT data on COVID-19 related information-seeking behavior in India between January 1 and May 31, 2020 in the form of relative search volume (RSV). We also used time-lag correlation analysis to assess the temporal relationships between RSV and daily new COVID-19 cases and tests.

Results:

GT RSV showed high time-lag correlation with both daily reported tests and cases for the terms “COVID 19,” “COVID,” “social distancing,” “soap,” and “lockdown” at the national level. In 5 high-burden states, high correlation was observed for these 5 terms along with “Corona.” Peaks in RSV, both at the national level and in high-burden states corresponded with media coverage or government declarations on the ongoing pandemic.

Conclusion:

The correlation observed between GT data and COVID-19 tests/cases in India may be either due to media-coverage-induced curiosity, or health-seeking curiosity.
“A New and Coherent Strategy?” Presidential attention and rhetoric in the era of Indian self-determination
Authors: Flaherty Anne F. Boxberger
Published: August 2021

This paper explores the dynamics of presidential attention and rhetoric on Native issues and peoples during the self-determination era. Using data from all public statements and papers of the presidents from 1969 to 2016, the work analyzes the level of attention and rhetorical frames of each president from Nixon to Obama, with additional comments on Trump. The analysis reveals that most presidents have given relatively little attention to Native issues compared to their overall volume of public statements, with Democratic Presidents Clinton and Obama offering the most attention. In addition, presidents have used very different rhetorical frames to address Native issues and peoples in their public statements. Presidential rhetoric has been characterized by fluctuating attention and frames, and presidents have not consistently supported Nixon's “new and coherent strategy” throughout the self-determination era.