bluuebunny/crossref_metadata_2025 huggingface dataset:
MAST CELLS IN PERIODONT PERIODONTAL DISEASE DISEASE
Authors: Marjanović D. , Anðelković Z. , Videnović N. , Mihailović B. , Matvijenko V. , Lazić D. , Dubovina D.
Published: November 2024

Periodontal disease is a chronic inflammatory disease that is largely attributable to infections with gram-negative bacteria and is characterised by both gingival inflammation and alveolar bone resorption. Beside macrophages, the second most common cells of the gingival inflammatory infiltrat are mast cells. Mast cells are heterogenous cell population which live from six months to one year. These cells are activated by differnt immunologic and non-immunologic signals. Activated mast cells can secrete a range of substances that regulate angiogenesis, tissue remodeling and wound healing, which include both degradation and synthesis of tissue components. Apart from that, mast cells have an important role in phagocytosis, antigen processing and presentation to T-cells. It is confirmed that gingival mast cells can express matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases, TIMP-1 and TIMP-2. This indicates that mast cells are likely to play an important role in inflammation and tissue degradation in periodontal diseases.
IMMUNE RESPONSE TO IMMUNOTHERAPY
Authors: Smiljić Lj.
Published: November 2024

Allergen-specific immunotherapy (SIT) is the practice of administering gradually increasing quantities of an allergen extractto an allergic subject to ameliorate the symptoms associated with the subsequent exposure to the causative allergen. The major objectives of SIT in alergy disorders are, in the short term, to reduce the allergic triggers precipitating symptoms, and, in the long term, to decrease allergy inflammation and nonspecific bronchial hyperreactivity when bronchial remodeling is not prominent. The mechanisms of SIT are complex but it was convincingly shown to act by modifying Th2 cell responses either by immune deviation (increase in Th0/Th1) or T cell anergy (decrease inTh2/Th0) or more likely both. Specific immunotherapy is the only treatment that may alterthe natural course of allergic disease.
BASIS OFRADIOBIOLOGICALEFFECTON MEN - RADIOBIOLOGICALEFFECTON SKIN
Authors: Relić M. , Relić G.
Published: November 2024

In this work we present a basic aspects of ionising radiation (afterward of depleted uranium), this effects to human organism, esspecially on radiobiological, health effects on human skin. Health effects ionising radiation on skin depends of its doses. High doses given stron reaction, already in a few days after radiation, and later manifestations arise after longer exposition lower doses this radiation. In this work we present a basics pathophysiological aspects, without specifical clinical manifestations of radiation dermatitis.
TREATMENT OF THE PATIENT WITH THE TRAUMATIC EXTRACTION OF THE PERMANENT UPPER - CENTRAL INCISOR TOOTH
Authors: Šurdilović D.
Published: November 2024

Traumatic extraction of permanent teeth (avulsion completa) is a serious teeth injury with uncertain outcome and it requires dentist's on duty fast and adequate reaction. In this study a complete therapy plan for eleven year old girl, who came to the Clinic because of avulsed teeth 11, third class fracture of tooth 12 and second class fracture of tooth 21, was showed. After clinical examination and upper frontal region X-ray, we started with replantation of the tooth 11, as well as with wirecomposite splint placement. After successfully done replantation and injured teeth endodontic treatment, prosthetic sanation of the patient was done. In this study, clinical picture of the patient one year after the injury was also showed.
EXHUMATION OFMASSIVE GRAVES AND SINGLE GRAVES ON THE TERRITORYOFKOSOVO AND METOHIJA(2001-2004)
Authors: Matejić S. , Todorović M. , Filipović T. , Milošević M. , Jakšiċ V.
Published: November 2024

Identification of victims during war and post war conflicts means for The Republic of Serbia the most important professional, scientific and ethical investigation. Before the process of identification forensics do the exhumation, very important part of process of which depends successful identification. On the Kosovo and Metohija, from 2001 till 2004. forensics did exhumation in some massive graves and in many single graves. Experiences of experts proove that the process of exhumation is very important becouse in that first phase collecting of evidence through forensic investigations have made “disappeared” victims “visible”, empowered survivors, corrected the historical records, and exposed cover-ups. Through forensic investigations including the identification of all injuries on the dead bodies, we faced with the marks and circumstances which followed the death under existing conditions on Kosovo and Metohija. Forensics promotes democratization and rule of law.
THE ROLE OF A FAMILY IN POLITOXICOMANIA OXICOMANIA
Authors: Šapić R. , Krvokapić Ž. , Nenadović M.H , Krivokapić M.
Published: November 2024

Any need of a drug addict to conform to his drug dependence is eliminated by a successfully accomplished closed system of addictive behaviour and circular change of the state of his mind. His addictive behaviour represents the so- called indestructible homeostasis of a drug - addict' s family. Meeting the drug- user's needs deprives him from any desire to deal with his own personality and behaviour. Only in cases when the addictive behaviour is thwarted by requests and even aggressive behaviour of the parents and other members of the society (environment) who ask for explanation, the sense of menace and effect of projected pursuer is convincingly achieved, which can often lead to aggression.Using the GRADIR scale, the investigation has reported that drug addicts' families are not as defective in sharing their emotions as they are defective in their structure, which intensifies irregularity that leads to drug use. If family were better structured, its member might not turn to drug.
STATISTICALAND EPIDEMIC ASPECT OF CHILDRENS DEPARTMENT, HEALTH CENTER FROM KOSOVSKA MITROVICA
Authors: Živković J. , Radovioć Lj. , Savić Z. , Jakovljević A. , Kostić N.
Published: November 2024

Its analyzed from a epidemic figurante aspect. The childrens department, health headquarters from Kosovska Mitrovica in the year of 2007. They were able to bring 748 children for healing. Down North Kosovo, they had 81% of children and another 7% from the village Priluzje and Plementina come. There was a increase in the number of incoming children in January and Febuary. And then the same time, in september and October. Half of the healed childrens age varies up to 2 years old. In a period of 6 days, they are able to heal 72, 6% of children. In the 94 stuctured diagnosises, they were able to show all the morbidity. Dominating sickness of the respitory system, in the winter season. And the digestive system in the fall season.
HISTOPATHOLOGICAL COMPARATIVE ANALYSIS OF THE PROSTATIC INTRAEPITHELIAL NEOPLASIAAND PROSTATIC CARCINOMA IN THE BIOPSY SPECIMENS
Authors: Preljević I. , Knežević M. , Stanković V. , Mihajlović Z.
Published: November 2024

Prostatic intraepithelial neoplasia (PIN) is putative premalignant lesions of the prostate. This lesion has role as precuror of prostatic carcinoma (PC), predictive role for PC and high coexistens with PC. Existed two grade of PIN: low grade PIN (LGPIN) and high grade PIN (HGPIN). PC is most important malignacy in man and has high mortality in male. The aim of research was to invastigated morphological comparative patterns of HGPIN and PC. We analyzed biopsy material of 299 cases (cs). We used histopathological metods of investigation. We found HGPIN in 42 cs (14.0%) with mean age 66.3 y and PC in 35 cs (11.7%) with mean age 70.7 y. HGPIN was most frequently in the seventh decade of life (54.8%), and PC in the eight decade (45.4%). Four common pattern of HGPIN were identified: tufting (78.6%), micropapillary (72.8%), cribriform (16.6%) and flat (9.5%). In 21 from 35 cs (60%) with PC was coexistent HGPIN. HGPIN we found in the periferial part in the 22 cs. (52.4%) and in the periurthral part of the prostate in the 12 Cs. (28.6%). HGPIN were multicentric in the 22 cs. (52.4%), in the 15 cs. (68.2%) in the periferial part, and in the 7 cs (31.8%) in the periurethral part of the prostate. PC in the 22 cs (62.9%) was localized in the periferial, and in the 7 cs in the periuretral portion of the prostate. PC was multicentric in 28.6%. Important histological patterns for distinction HGPIN i PC are: disruption of basal cell layer, perineural invasion, mitotic figures, multiple nucleoli, collagenous micronodules, infiltrative growth. HGPIN and PC we found in sufficient percentage. Both lesion were most frequently multicentric, periferial localisation and coexistent. Because of that these lesions needed serious clinical and histological investigations for patients.
+Gz ACCELERATION AS DINAMIC STRESS
Authors: Janićijević-Hudomal S. , Arsić-Komljenović G. , Mikić D. , Kenić J.
Published: November 2024

+Gz acceleration is unique dynamic stress to organism. Development of this occurrence depends not only to magnitude of acceleration but to onset rate and duration too. The most of former researches pointed to +Gz stress as significant stress to basic physiological mechanisms like cardiovascular and respiratory system. The new study was to examine responses of neuroendocrine and immune system to +Gz stress.
NEW THERAPEUTIC APPROACH FOR TREATMENT AGE-RELATED MACULAR DEGENERATION (AMD)
Authors: Jakšiċ V. , Žorić L. , Mirković M. , Stamenković D. , Vukša D. , Popović N.
Published: November 2024

Exudative age-related macular degeneration is leading cause of irreversible vision loss in developed countries. Subfoveal localisation of choroidal neovascular membrane is the most difficult form for treatment. At the last three years, the new group of agens well-known as anti-VEGF agens was approved for treatment of exudative AMD. In that purpose, intravitreally administrated agens is recommended. Efficacy and safety of anti-VEGF agens were proved in short-time follow up period.
INHIBINS INHIBINS - QUALITIES, QUALITIES, SIGNIFICANCE SIGNIFICANCE AND HIS ROLE IN PREGNANCY PREGNANCY
Authors: Vukotić M. , Trajković G. , Parlić M. , Ćorac A. , Mirković M. , Milošević N.
Published: November 2024

Inhibins are glycoprotein hormones of which there are two molecular forms, inhibin A and inhibin B. Classically, inhibin is known to have a negative feedback effect on pituitary follicle-stimulating hormone secretion. The fetoplacental unit produced inhibin throughout pregnancy. Inhibin Ais the predominant molecular form of inhibin in maternal circulation from 4 week of gestation. Although the precise biological function of inhibin Ain pregnancy is unclear, it is evident from recent studies that inhibin A could be a better marker of placental function than human chorionic gonadotropin because of its shorter half-life. The possible clinical application for the measurement of inhibin Ain early pregnancy could be in predicting miscarriage , Down's syndrome, preeclampsia and fetal growth restriction in the first and/or second trimester before the onset of yhe clinical symptoms. Inaddition, several evidences underline the potential role and the clinical usefulness of their measurements in the diagnosis, prevention,prognosis and follow-up of different gestational pathologies such as:threatened abortion, placental tumors, hypertensive disorders of pregnancy,intrautherine growth restriction,fetal hypoxia.The measurement of inhibin Aand activin Ainto the biological fluids of pregnancy will offer in the future further possibilities in early diagnosis,prediction and monitoring pregnancy diseases.
FUNCTIONAL CONDITION INFLUENCE ON STUDENTS REACTION TIME
Authors: Mišolić M. , Ivetić V. , Nestorović V. , Milanović Z. , Radović D. , Biševac B. , Erić M.
Published: November 2024

Nowdays, reaction time is most often used in data processing as a quantitative method and technique for information step and speed processing. The aim of this investigation was to examine everyday work pressure on reaction time nd among students. An examination included 30 students of 2 year of Medicine Faculty 15 males and 15 females. Audible and visual simple reaction time as well as choice reaction time for 2, 4 and 6 stimuli was used for reaction time measurement. Measurements were done three times a day. Achieved results acknowledge statistically significant improvement of reaction time at noon compared to reaction time in the morning in all samples except for visual simple reaction time for male students. For all kinds of stimuli, reaction time were significantly prolonged in the evening in both groups. Therefore, we have concluded that morning activities had positive impact on students functional condition but afternoon activities acted like an additional stress that altered students latent fatigue to clearly observable acute fatigue.
COMPARATIVE ANALYSIS OF ANTHROPOMETRIC AND SPIROMETRIC PARAMETERS IN ATHLETES
Authors: Popadić Gaćeša J. , Barak O. , Drapšin M. , Klašnja A. , Srdić B. , Karaba Jakovljević D.
Published: November 2024

Aim of this study was to determine characteristics and correlation between basic anthropometric and spirometric parameters in athletes of different sports and non sportsmen. Measurements were conducted on 140 male and female athletes: volleyball, basketball, soccer, handball players, runners, VESLACI and 60 non sportsmen, 30 female and 30 male. All measurements were conducted in the Laboratory for functional diagnostics at the Department of Physiology, Medical School, Novi Sad. BMI values were normal for all athletes except in handball players, whose average BMI was 25.70+/-2.35 2 kg/m . Average values of body fat percent (BF %) were significantly higher in female athletes, the lowest values were measured in female runners (determined by both methods anthropometry, bioimpedance), while in the group of male athletes the highest body fat was found in basketball players. Statisticaly significant gender difference was found for all anthropometric parameters. Athletes have significantly lower values of BMI and BF% compared to non sportsmen, and males compared to females. Those gender differences are the result of sex determined diferences in body fat distribution, and different length of sports activities. BMI is not a good predictor of body fat content in athletes, because it's high values indicates masculinity rather than fatness. Spirometric parameters show significantly higher values in athletes of both sexes, because ventilatory function is expected as an effect of chronic adaptation on training. Correlation differences between anthropometric and spirometric parameters can be explained by the age differences in our participants and the length of their sports activities.
ANTIOXIDATIVE POTENCY OF PLANT MELLITIS MELISOPHYLLUM
Authors: Janićijević-Hudomal S. , Kenić J. , Arsić-Komljenović G.
Published: November 2024

One of the paradoxes of life on the Earth is that, on one side, oxygen is necessary for living of aerobic organisms. On the other side, increased contrencations of oxygen and especially its reactive metabolites (reactive oxygen species) may lead to the development of number diseases such as Alzheimer, Parkinson, ischemia-reperfusion injury, coronary atherosclerosis, diabetes mellitus, hypertension, and cancer genesis, as well as in the aging process (1, 2,3). Amajor source of free radicals in biological systems is molecular oxygen (O2). By interacting with fundamental cell structures and biomolecules, reactive oxygen species (ROS) can lead to the development of many pathophysiological disorders (4,5). Active principles from plant family Lamiaceae (flavonoids and phenolic compounds, polyphenols), like plant Mellitis melisophillum, may act as new potential antioxidants.
THE HELICAL VENTRICULAR MYOCARDIAL BAND
Authors: Šulović Lj. , Smiljić Lj.
Published: November 2024

Helical ventricula myocardial bend of Torrent-Guasp is the revolutionary new concept in understanding global, three-dimansional, functional architecture of the ventricular myocardium. Anatomy of the VMB, and recent proofs for its segmental electrical and mechanical activation, undoubtedly indicates that ventricular filling is the consequente of an active muscular contraction. Specific septal arrangment of the ascedent segments fibers, their interaction with adjacent descedent segment fibers, elastic elements and intracavitary blood volumen explein the physical principes involvel in this action. Understanding this mechanism cudld be of particular importance in our efforts to prevent and treat diastolic heart failure.
THE EFFECT OF VERAPAMIL ON TRACHEA RESPONSE CAUSED BY HISTAMINE AND ACETILCHOLINE
Authors: Mitić R. , Biševac B. , Stanojević Z. , Bursać M. , Đokić T.
Published: November 2024

In the study with experimental animals in vitro conditions, the aim of the research was to examine the effect of verapamil on the even brawniness of the isolated organ of the respiratory ways (tracheas) in guinea-pigs on acetylcholine and histamine, and in that way, to examine local mechanisms of smooth muscle system but also to exclude the rest of the neurohumoral influences. The guinea-pigs of both sexes (average weight of 500-700 gr), were used for this experiment. 10 guinea-pigs were included in the experimental research; the trachea was taken from them after the immolation. The preparations of isolated organs of trachea were divided into two groups (A and B). The previous incubation of trachea -5 isolated by verapamil (1 minute) in concentration 10 M significantly reduced the contraction caused by acetylcholine -4 (ascent 21.49±9.63, r=0.97, p<0.05). Concentration of verapamil 10 M also caused significant fall of contraction (ascent -5 21.3±12.63, r=0.95, p<0.05). Verapamil in concentration 10 M significantly reduces the response of isolated trachea cau- -6 -5 -4 sed by histamine in concentrations 10 M and 10 M (slope 21.3±10.6, r=0.96, p<0.05).Concentration of verapamil 10 M significantly reduced the contraction of smooth muscles of isolated trachea caused by histamine (slope 15.46±10.47, r= 0.94, p < 0.05).
MICROANA MICROANATOMIC STUDY OMIC STUDY OF THE OPHTHALMIC THE OPHTHALMIC ARTERY
Authors: Vitošević Z. , Radunović M. , Milisavljević M.
Published: November 2024

The origin of ophthalmic artery (OA) and surrounding structures was investigated in 25 cadavers by three different methods: macroscopic, stereomicroscopic, and histological observations. The following results were obtained. In 42% of the specimens the origin of the OAwas observable in the cranial cavity and defined as the intradural type, running alongside the optic nerve within the subarachnoid space. The other 58% were named the extradural type of the OA, originated within the cavernous wall or cavity, and entered directly the optic dural sheath, thus no part of the OA was visible in the cranial cavity. OApassed through the optic canal within the dural sheath of the optic nerve. In 44% of our specimens the OAwas on the inferomedial side of the optic nerve at the entrance point to the optic canal. OAleft the optic canal at its lateral border in the apex of the orbit in 72% of our specimens. For descriptive purposes the intraorbital course of the ophthalmic artery has been divided into three parts. The first part usually runs along the infero lateral aspect of the optic nerve. The second part crosses over (in 88%) or under the optic nerve running in a medial direction. The third part extends medially to its termination. These anatomical data may provide important information for understanding the variety of the pathology in this region and is also useful for designing operative strategies.
THE ROLE OF STUFF IN TRANSPORT OF CRITICALY ILL OR INJURED PATIENTS IN OUR CONDITIONS
Authors: Pavlović A. , Jovanović A. , Trpković S. , Trajković G.
Published: November 2024

Quick, proper and efficient transport is an integral part of all measures taken in treatment and effective care of polytraumatized patients. Before or during the transport, without regard to the transportation means, such patients often need their airways to be protected, connection to mechanical ventilation, applying of oxygen, infusion solution, painkillers or some other drugs. Continual monitoring of vital functions is required part of treatment during transport of critically ill or injured patients. Their transport, beside adequate equipment, demands theoretically and practically well trained stuff. In most European countries anesthesiologists have primary role especially in interhospital transport (for example in transport of neurosurgical patient from local to university hospital). Unfotunatelly, in our conditions transport is often carried out by unsufficiently skilled medical stuff without adequate equipment and experience what may have an effect on treatment success and surviva.
THE MATHEMATICAL MODELS OF ALBUMIN AS DIAGNOSTIC PARAMETERS OF BLOOD-BRAIN BARRIER STATUS
Authors: Mirić D. , Katanić R. , Božović B. , Popović N. , Dragojević I.
Published: November 2024

The increased protein concentration in cerebrospinal fluid is among most prominent biochemical parameter of intensified passage of macromolecules through blood-brain barrier. It is often found in cases of meningeal inflammation, neurodegeneration, neoplastic and traumatic processes developed on brain or spinal cord structures. Protein concentration in cerebrospinal fluid is often determined, but determination of albumin concentrations as well as mathematical models utilizing albumin are more reflective to the pathologic processes on the brain and spinal cord. Our study was limited to the determination of referent values for our laboratory for cerebrospinal fluid albumin concentrations, albumin quotient, as well as albumin transudat and exudat in the function of the age of probands. The results of the study show great agreement with previously published data.
THE FOLLOW UP STUDY AND DYNAMICS OF THE CHANGES IN LIQUOR CONCENTRATION OF THE SEROTONIN AND EPINEPHRINE IN ACUTE CEREBRAL INFARCT
Authors: Čolić S. , Šternić N. , Mirić D. , Trajković G. , Smiljić Lj.
Published: November 2024

It is obvious that outcome of the cerebral ischemia depends on many of the metabolic reactions that accompany circulatory disturbance, and forcaming neurochemical changes on the cellular level. Cerebral ischemia accompany changes in the neurotransmitters from the group of the biogenic amines, that influence a great deal whole chain of reactions that lead 66 cell to ultimate death. This processes ease up an enables distribution of the cascade reaction in ischemia leisure. To this should be added the fact, that cerebral infarct is followed with selective disturbance on hematoencephal level for 64. monoamines. It is obvious that cerebral infarct involves changes in metabolism of the central neurotransmitters. This changes could have either short or long term consequences on the ischemic process outcome. Therefore our aim in this study was to investigate the influence of the biogenic amines, serotonin and epinephrine as possible markers in estimation of the neural damage, outcome of the ischemic cerebral stroke and clinical presentation throughout correlation in changes of their concentration in liquor. Investigation included 40 patients on hospital treatment on Neurology Clinic of the CHC Pristina. During the follow up study, we estimated changes in concentration levels of the serotonin and epinephrine in liquor throughout different time intervals, correlating to the neurology status, encountering neuroradiology methods CT and MRof the brain, as a criteria in diagnosing acute ischemic cerebral stroke.
THE HEALTH STATUS OF THE PERIODONTIUM IN SCHOOLCHILDREN IN THE REGION OF KOSOVO AND METOCHIA
Authors: Martinović B. , Milojković Z. , Cvetkoviċ A. , Stojanović B.
Published: November 2024

Periodontal diseases appear at the earliest age, they are progressive, long-lasting and if not treated lead to the loss of teeth in adults. By examining and identifying the frequency, range and severity of periodontium diseases, it is possible to evaluate the need for prevention and treatment of those affected with gingivitis and periodontophaty.The aim of the study is to determine the oral hygiene and periodontium status of the examined children in urban and rural areas. A total of 240 schoolchildren was examined. Significant presence of soft deposits was found in the examined children aged 12 and 15 years, disregarding the place of residence (IMN- 1.53 in town and IMN- 1.40 in the village). Calculus index values are significantly lower in the rural compared to the urban area for about 40% (0.26 in rural compared to 0.44 in urban area In relation to the place of residence (town-village), the status of the periodontium evaluated by CPTIN Index, shows that only 14.6% of the examined children need no treatment. Within the necessary treatment, 32.9% of the examinees need training in oral hygiene and 40.8% of them need removal of soft and hard deposits. Considering the recorded values from these two typical areas, it can be concluded that dental protection in these two regions has no significant influence on oral health. Thus, it is necessary to plan and conduct permanent prevention, early diagnosis and timely therapy.
COMPARATIVE ANALYSIS OF TOOTH SIZE PREDICTION BY TANAKAAND JOHNSTON AND MEASURED WIDTHS OF TOOTH ON OUR POPULATION
Authors: Vujačić A. , Pavlović J. , Vukićević V.
Published: November 2024

The objectiv of this study were to evaluate the applicability of the methods of Tanaka and Johnston predictions to our population.60 dental study casts(30 male and 30 female patients)were used.The measured sum of the width of the permanent canine and premolars were compare with values obtained from Tanaka-Johnston formula.The method of Tanaka-Johnston were tended to exaggerate the actual sum of the lower permanent canine and premolars for male and female samples,with statistically significant differences.
ECHOCARDIOGRAPHIC DIAGNOSIS OF LEFT VENTRICULAR MYOCARDIAL HYPERTROPHY
Authors: Sovtić S. , Marčetić Z. , Stolić R. , Perić V. , Novaković T. , Jovanović A. , Lazić S. , Šipić M.
Published: November 2024

The existence of left ventricular hypertrophy is an independent prognostic factor for cardiovascular morbidity and mortality. Heterogenous factors lead to left myocardial hypertrophy. The most frequently factors are: arterial hypertension, valvular heart disease (aortic stenosis and insufficiency, mitral insufficiency), hypertrophic myocardiopathy, left myocardial hypertrophy after myocardial infarction... For making the diagnosis of left ventricular myocardial hypertrophy used electrocardiography („voltage“ and „repolarization“ criteria) and echocardiography. Echocardiography is the gold standard for diagnosis of left ventricular myocardial hypertrophy. Left ventricular mass was estimated by the modified formula 3 3 using measurements obtained in accordance with the Penn convention: MLK = 1,04 (LDDd+PWDd+IVSDd) - (LVDd) - 13,6 Where LDDd is diastolic left ventricular internal dimension, IVSDd is diastolic ventricular septal thickness and PWDd 2 is diastolic posterior left ventricular wall thickness in diastole. LV mass indexed by body surface area (g/m ). By Penn con2 2 vention left ventricular hypertrophy criteria were ≥134 g/m for men and ≥110 g/m for women.
RESULTS OF THE POLL RESEARCH AMONG PHARMACISTS EMPLOYED IN STATE AND PRIVATE PHARMACIES OF SOUTH BACKA DISTRICT
Authors: Vojnović M. , Stanulović M. , Jakovljević V. , Samojlik I.
Published: November 2024

An anonimous poll was conducted, which included pharmacists employed in state and private pharmacies from Novi Sad, Backa Palanka, Bac, Temerin and Odžaci (South Backa district). The group polled was a representative sample compared to the overall pharmacists number. The poll was conducted due to the fact that routine health statistics does not provide enough representative data on drug accessibility to patients and to try to answer how administrative limits interfere with the choice of medicaments. Obtained results suggest that the biggest problem is the lack of A list medicaments, so the patients are forced to buy medicaments in private pharmacies or even in the neighboring countries. The majority of the pharmacists polled are of the opinion that the participation in state pharmacies is low. There are no significant differences in the opinion of the pharmacists from both state and private pharmacies concerning the medicament consumption, both groups are of the opinion that we are facing excessive medicament consumption, above the real need.
FREQUENCY OF CAESAREAN SECTION ON THE MATERIALAT KOSOVSKA MITROVICA HEALTH CENTER DEPARTMENT OF OBSTETRICS IN THE PERIOD OF 1992-2001
Authors: Cvetnić D. , Zakić S. , Relić G. , Džeković M. , Jakšiċ Z. , Vlašković R. , Milenković M. , Savić M.
Published: November 2024

20.161 women were delivered at Kosovska Mitrovica maternity ward in the period of 1992-2001. Out of this, in 1.648 cases Caesarean section had been performed, which means that the frequency of this surgical process was 8.17%. The percent of the Caesarean section is in growth every year starting from 1997, but it has reached its maximum of 20 % in this year. In the year of 2000, 44.90% of pregnant women who had Caesarean section done were from serbian enclaves. In the year of 2001 that percent is even bigger and it reaches 58%. Every second pregnant woman who had surgical operation was from serbian enclaves in the last two years. It can be pointed out that more than a half of pregnant women who had surgical operation were in the age of 19-25. As a conclusion, we can say that 8.17% of Caesarean section is absolutely well in the period of ten years, but we were not satisfied with the great number of Caesarean section in the last two years.
ALPHA LIPOIC LIPOIC ACID IN CLINICAL ACID IN CLINICAL APPLICA APPLICATION
Authors: Vučinić B. , Mitić R. , Dimić S. , Milanović Z. , Sovtić S.
Published: November 2024

Alpha lipoic acid is the most efficient of all known antioxidants for its lipo and hydrosolubility which enable easy penetrability in cytoplasm making its protection of free reactive radicals, energetic metabolism, regulation of genetic expresion etc. It has wide application in prevention and in therapy of diabetic angiopathy, neuropathy, cardiovascular, cerebrovascular, neurodegenerative disease, lesion, (insufficiency) of liver, HIV, intoxication with hard metals, mycotoxins etc. An important proprety of lipoic acid is its possibility to prevent or remove lesions which are caused by application aminogycosides and haloperidol (ototoxicity, nephrotoxicity) according to its wide application. R isomer of lipoic acid is physiological substance presented in organism which synthesize in in liver enabling its its application in relatively high dose for a longer period of time.
LYMPHOPOETIC FUNCTION OF THE THYMUS
Authors: Leštarević S. , Anðelković Z. , Mitić N.B. , Milosavljević Z. , Milošević M.
Published: November 2024

The process of multipotential lymphatic stem cell maturation and differentiation into immunocompetent T cells is accomplished by the expression and deletion of specific surface CD antigens. The CFU-Lstem cells enter the medulla of the thymus via a post capillary venule and then migrate to the periphery of the thymic lobule. The presence of CD2 and CD7 molecules on the cell surface indicates an early stage of differentiation. This is followed by expression of the CD1 molecule, indicating the midstage of Tcell differentiation. As maturation progresses, the cells express TCRs, CD3, CD4, and CD8 molecules. It seems that intensity of interreacion between TCR/co receptor molecule complex and self peptide/MHC complex determine the outcome of the thymocite selection process. If the lymphocyte recognizes self MHC and self or foreign antigen, it will survive the selection (positive selection); if not, death of the cell will occur. Cells that pass the positive selection test leave the cortex and enter the medulla. Here they undergo another selection process in which cells directed to selfantigen displayed by self MHC are eliminated (negative selection). Cells that survive that selection then become either cytotoxic CD8+ Tlymphocytes or helper CD4+ Tlymphocytes.
BACTERIAL ENDOCARDITIS IN PATIENTS WITH ALCAPTONURIC OCHRONOSIS
Authors: Smiljić Lj. , Ristić S. , Antić M.
Published: November 2024

Alkaptonuria is one of 4 disorders originally defined as an inborn error of metabolism. The hallmark of the disease is passage of urine that becomes black when left standing. There is a familial pattern of inheritance. The defect lies in the catabolic pathway of tyrosine. The product, homogentisic acid, in deficiency of the hepatic enzyme homogentisate 1,2- dioxygenase (HGO) accumulates in the blood, but is rapidly cleared in the kidney and excreted. Upon contact with air, homogentisic acid is oxidized to form a pigmentlike polymeric material responsible for the black color of standing urine. Although homogentisic acid blood levels are kept very low through rapid kidney clearance, over time homogentisic acid is deposited in cartilage throughout the body and is converted to the pigmentlike polymer through an enzyme-mediated reaction that occurs chiefly in collagenous tissues. As the polymer accumulates within cartilage, a process that takes many years, the normally transparent tissues become slate blue, an effect ordinarily not seen until adulthood. The earliest sign of the disorder is the tendency for diapers to stain black.. but in most cases desease is hardly diagnosed before the fourth decade of life, external signs of pigment deposition, called ochronosis, begin to appear. The slate blue, gray, or black discoloration of sclerae and ear cartilage is indicative of widespread staining of the body tissues, particularly cartilage. The hips, knees, and intervertebral joints are affected most commonly and show clinical symptoms resembling rheumatoid arthritis. Because of calcifications that occur in these sites, however, the radiologic picture is more consistent with osteoarthritis.
THE STATE OF ALIMENTATION IN PUPILS OF 3rd, 5th AND 7th GRADE IN SERBIAN ENCLAVES IN KOSOVSKO POMORAVLJE IN 2008/2009.
Authors: Milutinović S. , Milanović M. , Živković J. , Dimeski Z.
Published: November 2024

670 students, of 3rd, 5th and 7th grade, were examined. 50,6% were boys, 526(78,51%) healthy (3<PB<90), that is well nourished students, (257-38,36%) boys and (269-40,15%) girls. There is statistically significant frequency of normally nourished children of 3rd, 5th and 7th grade in comparison to the whole frequency of appearing of the numbered eating disorders (p<0,001). Undernourished (PB) were 18 students (2,68%), 9 boys (1,34%) and 9 girls (1,34%). Malnutrition is statistically the least frequent eating disorder with children of 3rd, 5th and 7th grade. Pre-obese (90<PB<97) were 92 students (13,73%), where 47 were boys (7,01%) and 45 were girls (6,72%). Pre-obesity is statistically the most frequent eating disorder among children of 3rd, 5th and 7th grade (p<0,05). 34 students (5,07%) were diagnosed with obesity, 26 (3,88%) boys and 8 (1,19%) girls. Statistically the obesity appears more often with boys than with girls of the same age (p<0,001). In general the least manifested eating disorder with students of 3rd, 5th and 7th grade, but also in each class separately, is undernourishment, which appears with the same frequency both with boys and girls. Generally the most manifested disorder in nourishment with students of 3rd, 5th and 7th grade, but also in each class separately, is pre-obesity which appears with the same frequency both with boys and girls. The level of obesity is the highest with the students of 3rd grade, and the lowest with the students of 5th grade.
ELECTROCARDIOGRAPHIC CHANGES IN PATIENTS WITH SYSTEMIC DISEASE OF CONNECTIVE TISSUE
Authors: Regić E. , Sovtić S.
Published: November 2024

Changes in the heart and blood vessels are one of the major complications that substantially contribute to morbidity and mortality of patients with systemic diseases of connective tissue.All anatomical structures of the heart can be affected by pathological process and noted the multiple pathogenic mechanism leading to changes in pericard (thickening of leaves, calcification, pericardial outburst), atrial and ventricular arrhythmia, disorders of implementation, changes in heart failure in terms of whiskered or stenosis, myocardial ischemia and heart failure. The aim was also to test the registration of the most common heart rhythm disorder and implementation as well as changes in the ST segment and T wave of electrocardiogram of patients with systemic diseases of connective tissue. The study involved 70 patients in two groups. The first group was 50 patients with systemic disease of connective tissue, and the second control group of 20 patients with lumbal syndrome. Electrocardiographic changes were observed in 38(54,3%) respondents. Observed by groups of patients with connective tissue diseases were registered in 35 (70%) and in the control group in 3 (15%) patients with a statistically significant difference (p<0,01). Statistically significant difference was noted in the appearance of ventricular premature complex, changes in ST segment and T wave.
FREQUENCY AND COMPLICATIONS ANGIOEDEMA QUINCKE AMONG HOSPITALIZED PATIENTS
Authors: Krstić N. , Relić M. , Belić B. , Stolić R. , Sovtić S. , Novaković T.
Published: November 2024

Introduction: Approximately 15-23% of the general population have had urticarial rush during their lives. Goal: Examination of the urticarial frequency and urticarial etiopathogenesis among hospitalized patients. Sources and methodology: Retrospective analysis of the data extracted from patients' medical history at the Clinical Center of Kragujevac, Department for Dermatology and Venereology. Statistical methods used include proportional relations with tabular and graphical representation of the results gathered. Results: Out of 228 hospitalized patients in 2007, total of 28 (or 12.28%) were treated for Urticaria. The disease is more frequent among the following groups of patients: female population (total of 23, or 82.1%); people between 30 and 60 years of age (total of 15, or 53.6%); urban area population (total of 24, or 85.7%); patients with Dg. Urticaria acuta diagnosis (total of 19, or 67.8%); Dg. Oedema Quincke (total of 6, or 21, 4%); et people with cardiovascular diseases (total of 9, or 32.2%). The disease is more frequent in Spring, during the period April-June (11 patients, or 39.3%) with the greatest frequency in May (7 patients, or 25%). According to etiological samples the most prominent types of Urticaria among patients were: idiopathic (13 patients, or 46.4%), due to medications (5 patients, or 17.9%), nutritional origin (4 patients, or 14.3%), psychological factors (3 patients, or 10.7%). Considering complications, 6 patients (21.4%) had Quincke's Oedema, while 7 patients (25%) had allergic reactions to penicillin. Regarding outcome of the disease, total of 23 patients (82.1%) have been successfully cured. Discussion et Conclusion: The greatest number of serious urticarias with complications has been inducted by non-physical factors, mostly of immunological nature, while physically inducted urticaria have had less severe symptoms and required shorter time to cure. Nevertheless, exact causes for most types of urticaria are unknown, so continual research of causes, as well as courses, complications and treatments of this serious disease is necessary.
VIRAL HEPATITIS A IN MUNICIPALITY OF PRIJEDOR
Authors: Anðelković D.
Published: November 2024

Acute viral hepatitis A (HAV) is a benign self-limited disease, which does not become chronical and does not require obligatory hospitalization. It's an intestinal infectious disease with a dominantly fecal-oral way of transmission. Endemic epidemic appearance of this disease on the municipality of Prijedor, with a very high level of incidence, from the sixties of the 20-th century, has put the viral hepatitis among the priority problems of epidemiologic practice. During the period 1965-2007. in Prijedor there were 5707 registered cases of HAV contaminated people and three death cases. From 1990 it has been noticed an epidemiologic regression of HAV followed by its complete absence during the period 1997-2007. Studies of reasons of HAV regression have been conducted by a descriptive-epidemiologic method according to sex, age, ethnic affiliation, place of residence, seasonal appearance of disease, and the way of water supply. It has been determined that there is no statistically important differences among contaminated people according to sex, differences in other treated parameters correspond to the data from literature [1,2]. Seroconversion has been proved in 53 persons or 55,2% of tested people. Percentage of sero-positive people was 93,7% among people older than 60 years of age and 79,2% among the refugee population. Based on studies, the epidemiologic regression of HAV from the 90-ties of the 20th century, is explained by the fact that this disease appears in the interepidemic period, that there is a significant collective immunity of population with the HA virus, and the most important, the basic epidemiologic factors which contribute to the spreading of disease have been removed - the majority of population live in the urban and suburban areas where a hygienic water supply has been provided for. Also the customs and habits of population have been significantly changed. 
PHYSICAL-TECHNICAL PRINCIPLES OF COMPUTERIZED TOMOGRAPHY
Authors: Jovanović T.
Published: November 2024

Theoretical principle of computerized tomography was set by Czech mathematician J. Radon in 1917.The development of computerized tomography is connected with the name of A.M Cormack who, in 1963, started with the research directed at X-ray beam intensity measurement after passing through certain substance.First computerized tomography appartus was installed in Atkinson-Morley hospital in October in 1971 in London. Computerized tomography is based on making transverse(axial) cross-section of body parts,by X-ray beam passing through visible body part and by measurement of X-ray absorption degree using detectors. A cross-section picture of certain body part is obtained on a monitor as a final result of CT examination. A system of picture digitalisation and application of grey scale concept is particularly complex. Basic elements of CT are gentry, patient's bed, high-voltage generator, working and computer console, system for transferring picture on a film or other electronic media. Densimetric tissue values can be measured on the obtained CT picture. A change can be isodense, hypodense or hyperdense. Density change is expressed in Hounsfield units. Contrasting remedies can be applied, during CT, intracanalicular or intravenous. A better quality survey of changes increasing tissue density is obtained using them. CT application is indicated in diseases such as:neurocranium, visceral cranium, spinal column, thorax, abdomen, skeletal, joint and muscular system. X-ray side effects and precaution risks are being described in the text.
POSTERIOR CORTICAL ATROPHY: A CASE REPORT
Authors: Milošević V. , Dačković J. , Ocić G. , Ilić V. , Salak B.
Published: November 2024

Posterior cortical atrophy (PCA) is a slowly progressive dementia characterized by an early onset of visual agnosia, followed by components of Balint's syndrome, Gerstmann's syndrome, and transcortical sensory aphasia. The most striking neuropsychological feature of the syndrome is the dissociation between prominent visuspatial disfunction and relatively preserved memory, personality and insight. PCA is a rare syndrome. Autopsied brains of PCA patients have shown a neuropathology of Alzheimer's disease (AD). PCA is not just AD with prominent visual deficits but a distinct clinical syndrome. Neuropsychological examination is fundamental for the diagnosis. It is very important to assess visuspatial functions. Here we present a case of slowly progressive dementia with visuspatial disturbances and apraxia but relatively preserved memory functions, personality and insight.
VERBAL DISORDERS IN PATIENTS SUFFERING FROM HEART ATTACK IN BORDER SUPRATENTORIAL ARTERY DISTRIBUTION
Authors: Mitrović V.
Published: November 2024

In the group of 30 patients with infarction in the border areas has found a total of 11 patients with anterior watershed infarcts between the artery cerebri anterior and artery cerebri media, 15 patients with posterior watershed infarcts between the artery cerebri media and artery cerebri posterior, and 4 patients with subcortical watershed infarcts between surface and deep branch artery cerebri media. Supratentorial watershed infarcts in the dominant hemisfere were seen in 21 patients, while in subdominant in 9 patients. Each type of watershed infarcts was characteristic neurologic picture. Results of this study depict to high incidence of aphasic disturbances, which is consistent with the anatomical presentation of the speech affected both the anterior ares cortical stroke in transcortical motor aphasia, and the posterior of transcortical sensory aphasia.
ANALYSIS OF CHANGES AND ACCUMULATION OF LIPOFUSCIN PIGMENT IN CELLS OF THORACIC GANGLIA OF SYMPATHETIC TRUNK DURING AGING
Authors: Filipović T. , Vitošević Z. , Mandić P. , Đukić N. , Milisavljević M. , Stefanović P.
Published: November 2024

In the region of the thorax there are ten till twelve ganglia (ganglia thoracica); wich are white; triangle and irregular shape; rarely fusiform (spindle-shaped) or round. In the upper part of the thorax; ganglia are located in front of of the neck of ribs (collum costae); and in the middle part they are in front of head of ribs (caput costae). In the lower parts; they are near the vertebral bodies; therefore both of the trunks are slightly convergent. In this part; there are no branches which connected both sides of the sympathetic trunk. Lipofucin is yellow-brown; autofluorescent pigment; accumulated during aging in the lysosome of postmitotic cells; such as neurons.
REGULATORY T LYMPHOCYTES
Authors: Arsović A. , Radić I. , Savić S. , Ilić B. , Baksić D.
Published: November 2024

Regulatory T cells represent unique CD4+CD25+ population of T lymphocytes, which are involved in many immunological events. These cells have very important role in maintaining peripheral tolerance, prevention of autoimmune diseases, in immunological respond to infection, particularly by intracellular microorganisms as well as in a process of tumorogenesiz. There are two populations of regulatory T cells: natural regulatory T cells - nTregs and adaptive, inducible regulatory - iTregs. They differ between each other in accordance to the place of creation, in accordance to the specificity of the T cell receptor, as well as the action mechanism. nTregs and the other T cells arise in thymus, which provides specific inductive environment for maturation and immunological education of progenitor cells to imunocompetent T cells. iTregs arise on periphery from the conventional CD4+ T cells after stimulation by antigen under the different conditions. There is number of subpopulations of iTregs and the most important are Tr1 and Th3 cells. Tr1 cells produce big amounts of interleukin 10 (IL-10), and they are called IL-10-secretory regulatory cells, whereas Th3 cells are necessary for maintenance of peripheral tolerance to mucous surfaces, through their dominant cytokine TGF-â (transforming growth factor-â) and they are most widely spread in the mucosa of the digestive tract. Previous researches have shown that regulatory T cells achieve their suppressor activity via inhibitory cytokines, cytolysis, and induction of metabolic disorders and modulation of maturation or function of dendritic cells.