bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytokine profile in patients with acute myocardial infarction with and without complications
Authors: Aimagambetova A. O. , Karazhanova L. K. , Kotlyar A.
Published: November 2020

The aim of this study was to evaluate the prognostic role of the cytokine profile in patients with ST segment elevation myocardial infarction (STEMI). Materials and methods. In the present paper we studied cytokines IL-6, IL-1β, IL-10, TNFα and CRP in 81 patients with different course of STEMI. Results. In patients with complicated course of STEMI a significant increase in the concentration of IL-6, IL-10, FNOα, CRP was recorded on the 1st, 7th and 14th days compared with control group of healthy subjects and a group of patients with uncomplicated STEMI. Concentrations of TNFα>35.49 pg/ml, IL-6>33.37 pg/ml, IL-10>34 pg/ml, CRP>10.84 mg/l on day 1 may suggest cardiovascular complications in STEMI patients within 1 year after the onset of the disease. We have not found reliable prognostic levels of IL-1β, as the concentration of this cytokine remained within the accepted normal range.. Discussion. It is concluded that initially elevated levels of CRP l, TNFα, IL-6, IL-10 in the blood make it possible to identify groups of patients with myocardial infarction with ST-segment elevation at high risk of cardiovascular events throughout the year.
Relationship between smoking and indicators of systemic inflammation in patients with coronary heart disease
Authors: Bazdyrev E. D. , Polikutina O. M. , Kalichenko N. A. , Slepynina Yu. S. , Uchasova E. G. , Pavlova V. Yu. , Barbarash O. L.
Published: November 2020

Aim. To estimate the severity of systemic inflammation in subjects with coronary artery disease (CAD) without bronchopulmonary system comorbidity depending on smoking factor. Materials and methods. The subjects were divided into groups depending on smoking factor. We estimated the following laboratory markers of nonspecific inflammation: interleukine (IL)-12, -1β, tumour necrosis factor-α, matrix metalloproteinase-9, C-reactive protein. The examination of lungs respiratory function included spirometry, body plethysmography and assessment of diffusing lung capacity. Results. 29.9% of the subjects with CAD smoked, 40% reported discontinuation of smoking in their histories. Smoking in CAD subjects without the history of bronchopulmonary system comorbidity was associated with a higher level of inflammatory markers (IL-12, IL-1β, TNF-α, ММР-9 and CRP) than in subjects who ceased to smoke and those who have never smoked. No differences in the levels of inflammatory markers were revealed in subjects who had smoked before and never smoked. Conclusion. Smoking is widespread among CAD subjects. It is associated with a higher level of markers of nonspecific inflammation as compared to subjects who have never smoked before or ceased smoking.
Pemphigus acantholyticus
paraneoplastic: literature review and case report
Authors: Ufimtseva M. A. , Bochkarev Ju. M. , Gurkovskaya E. P. , Nikolaeva K. I. , Lesnaya O. D.
Published: November 2020

The article describes the clinical observation of a rare severe dermatosis, paraneoplastic acantholyticus pemphigus, associated with colon cancer with reference to pathogenesis, clinical variations and difficulties of diagnostics of this condition.
Resistin: biological and pathophysiological effects
Authors: Verbovoy A. F. , Tsanava I. A. , Sharonova L. A.
Published: November 2020

The adipose tissue is an endocrine organ producing large amounts of hormone-like substances, such as adipokines . Their properties, biological and pathophysiological effects have recently attracted much attention of researchers. This review article is focused on resistin and its role in the development of insulin resistance, cardiovascular diseases, and atherosclerosis.
Wavelet-analysis of central hemodynamics rhythms inpatients with disseminated sclerosis and disturbed cognitive status
Authors: Molchanova Zh. I. , Chibisov S. M. , Ragozin O. N.
Published: November 2020

The wavelet analysis of rhythm parameters of central hemodynamics in patients with multiple sclerosis (MS) and compromised cognitive status is of great interest for better understanding formation of neurogenic disorders of regulation of blood pressure (BP) associated with organic lesions of brain and higher nervous system at large. Aim. To study circadian hemodynamic parameters in patients with MS depending on cognitive status. Materials and methods. 55 patients with verified diagnosis of disseminated sclerosis (DS) underwent standard neurological examination. A BPLab portable system (Russia) was employed during 24 hours for analysis of diurnal hemodynamic parameters using the BPLab v.2.1 software in combination with the original wavelet analysis for determining the rhythmic structure of individual characteristics and evaluating synchronization and coherence of the described parameters. Results. The observed disturbances of temporal organization of the rhythms of central hemodynamic parameters due to climatic and geographical features of the Northern region in patients with DS manifested themselves as ultradian desynchronosis. In the group of DS patients with cognitive impairment, disintegration of the time structure was characterized by bursts of rhythmic activity in the form of intercalated rhythms with periods of 12, 8 and 6 hours and non-uniform distribution during the diurnal cycle. No increase of the average BP values in the presence of a large number of risk factors for the development of hypertension in the form of non-modifiable and modifiable complications of pathogenetic therapy was documented. Conclusion. The established rigidity of the mechanisms regulating BP in patients with DS may be due to an organic lesion of the autonomic nervous system at the cerebral, spinal or peripheral levels, and even more so to the disturbed higher nervous activity concomitant with impaired cognitive functions. This clinical study may suggest the inverse model of comorbidity (dystrophy) with the abnormal relationship between pressor and depressor mechanisms of BP regulation and leveling the influence of risk factors on the development of arterial hypertension.
Clinical significance of peculiarities of the lesions of the vascular bed associated
with pulmonary thromboembolism
Authors: Bachurina M. A. , Mazur V. V. , Mazur E. S.
Published: November 2020

Aim. To study effect of the level of vascular obstruction on the clinical manifestations of pulmonary embolism (PE). Material and methods. 63 patients with PE were included in this study. PE was verified by multidetector computed tomography (MSCT) with pulmonary angiography. 43 patients with high-risk PE survived the first week of the disease. In the remaining 20 patients with community-acquired pneumonia PE was diagnosed using MSCT pulmonary angiography in the first week of illness. Results. Obstruction of the trunk of the pulmonary artery or its lobar branches was detected in 34 (79.1%) patients with a high risk of PE and in only 2 (10%) ones with low-risk PE (p <0,001). The development of pneumonia complicated the course of the disease in 14 (32.6%) patients with a high risk of pulmonary embolism. The clots in the segmental branches of the pulmonary artery were identified in 9 (64.3%) patients with pneumonia. In high-risk patients with PE without pneumonia the lesion of segmental branches was detected only in 1 (3.4%) case (p <0,001). In patients with pneumonia at low risk of PE, the obstruction segmental branches was detected in 17 (85%) cases. Conclusion. The development of obstructive shock in PE is associated with a trunk embolism and/or the main pulmonary artery branches embolism. Infarction pneumonia is associated with the lesions of segmental branches of the pulmonary artery.
Peculiarities of the clinical picture of arterial hypertension depending on polymorphic variant of AGTR1 gene
Authors: Zotova T. Yu. , Kubanova A. P. , Azova M. M. , Aut Aissa Amira
Published: November 2020

According to the literature, arterial hypertension is a multifactorial disease with a significant genetic component; therefore, the study of pathogenic mechanisms of this disease depending on gene polymorphism of the angiotensin system, in particular AGTR1, is of special interest. This study involved 30 patients, in 15 of whom arterial hypertension was diagnosed as a component of metabolic syndrome while the remaining 15 ones had isolated arterial hypertension. The genotyping of patients was performed using the polymerase chain reaction and detection of amplification products by horizontal agarose gel electrophoresis. DNA was extracted from blood samples. All patients underwent 24-hour BP monitoring (ABPM). Two groups were formed according to the results of PCR: one consisted of patients with the AGTR1А1166А genotype (n=16) and the other included patients with the AGTR1А1166СorAGTR1С1166С genotypes (n=14). The groups were matched for age, sex, body-weight index (BWI), and waist circumference (WC). We studied the features of arterial hypertension, the clinical course including duration of AH, maximum and minimum values of systolic and diastolic blood pressure during 24 hours, the degree of night-time drop in BP, and effects of antihypertensive therapy. It was shown that systolic blood pressure, duration of the disease, comorbidity, effects of the treatment, the frequency of metabolic syndrome were significantly different in the two groups. It was concluded that hypertension and metabolic syndrome may develop synchronously in patients with the C allele of the AGTR1 gene.
Depression and other nonmotor manifestations of Parkinson’s disease
Authors: Zhukova I. A. , Zhukova N. G. , Alifirova V. M. , Nikitina M. A. , Izhboldina O. P. , Brazovskaya N. G.
Published: November 2020

Background. The occurrence of emotional, cognitive, behavioral disorders associated with Parkinson’s disease is on the average 1.5-3 times higher than in the general population of the same age. At least one neuropsychiatric symptom is diagnosed in 77% of the patients and 46% have combination of three or more disturbances. Non-motor disturbances are manifested at all stages of Parkinson’s disease, but information about the relationship between their frequency and manifestations and the duration and severity of the disease is rather contradictory. Aim. To evaluate the prevalence and severity of depression and other non-motor symptoms in patients with Parkinson’s disease. Materials and methods. 206 patients at the average age 65.9±9.7 yr with Parkinson’s disease receiving pharmacotherapy were studied. The clinical assessment was carried out using the Unified Parkinson’s Disease Rating Scale, Hoehn & Yahr Scale, Beck depression inventory II, Hospital anxiety and depression scale, Apathy Scale, Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale, Montreal Cognitive Assessment, Parkinson’s Disease Quality of Life Questionnaire- 39, Medical Outcomes Study 36-Item Short Form. Results. 30.9% of the 62 patients with Parkinson’s disease suffered mild, 56 (27.4%) moderate, 21 (10.2%) severe depression and only 67 (32.5%) patients had no depression. The study revealed correlation of depression with apathy (r=0,488; p<0,001), low quality of life according to the PDQ-39 (r=0,471; p<0,001), cognition (r=0,451; p<0,001), emotional well-being (r=0,450; p≤0,001), anxiety (r=0,436; p<0,001). Conclusion. The prevalence of depression in patients with Parkinson’s disease is up to 67.5%. The proportion of patients with severe depression reaches 10.2%. Depression is one of the most frequent non-motor syndromes of Parkinson’s disease deteriorating the quality of life of the patients.
Diagnostics of methyl alcohol intoxication: possibilities
and prospects
Authors: Sarmanaev S. Kh. , Zaborskikh I. V. , Simonenko V. B. , Dulin P. A.
Published: November 2020

Intake of toxic alcohols especially methyl alcohol posses a serious threat to health. Despite relatively low toxicity of methanol (hazard class III), its metabolite formic acid resulting from biotransformation of methyl alcohol by alcohol dehydrogenase is ranked among substances creating a high risk of toxic action. The long period of methanol toxification (~48 hr) makes difficult diagnostics of intoxication and therefore delays provision of emergency medical aid. It imposes high requirements on express diagnostics of methyl alcohol intoxication (Т51.1 ICD-10). The main diagnostic modality - routine evaluation of osmolar and anion gaps, has advantages and disadvantages. Drawbacks of emergency medical aid to the victims of methyl alcohol intoxication necessitates the search for new diagnostic options some of which sre discussed in the present article.
The importance of chronic kidney disease for the assessment of risk of adverse outcomes after myocardial infarction
Authors: Karetnikova V. N. , Kalaeva V. V. , Evseeva Maria V. , Gruzdeva O. V. , Zykov M. V. , Kashtalap V. V. , Shafranskaya K. S. , Barbarash O. L.
Published: November 2020

Renal dysfunction (RD) in the acute phase of myocardial infarction (MI) is pivotal for the risk stratification of adverse long-term outcomes after myocardial infarction and, therefore, requires further study. Purpose. To determine the role of CKD and renal dysfunction (in the acute phase of MI) in the adverse long-term post-MI prognosis. Material and methods. 954 patients with ST-segment elevation myocardial infarction (STEMI) were enrolled in a registry study, performed in the period from 2008 to 2010 at the Kemerovo Cardiology Dispensary. All patients were assigned to two groups according to the presence of concomitant CKD. Serum creatinine levels were measured at the time of admission and on 10-12th days, with further calculation of glomerular filtration rate (GFR) using the CKD-EPI equation. Patients without CKD were assigned to Group I (n = 616 (64.5%), and STEMI patients with CKD to Group II (n=338 (35.4%). Observations during the three-year follow-up period were evaluated from the end-points. Results. The factors associated with mortality among patients with CKD were as follows: left ventricular ejection fraction (LVEF) < 40% at the time of admission (OR 2.1; 95% CI 1.0-4.4), signs of RD at the time of discharge (OR 2.5, 95% CI 1.0-5.9), non-performance of myocardial revascularization (OR 3.1, 95% CI 1.4-6.8). The long-term prognosis in the group of patients without CKD depended on the following factors: non-performance of PCI (OR 2.1, 95% CI 1.0-4.3), severe AHF (Killip class) (OR 3.5, 95% CI 1.9-6.7), LVEF < 40% (OR 2.0, 95% CI 1.0-3.8), and older age (OR 2.0, 95% CI 1.0-3.9). Conclusion. Renal dysfunction (regardless of the presence of CKD) diagnosed in the acute phase of MI as well as left ventricular dysfunction (EF < 40%) were found to affect long-term mortality risk in the post-MI period.
Evolution of the views on pathogenesis of autoimmune thyroid diseases and
prospects for their target therapy
Authors: Gel’tser B. I. , Zdor V. V. , Kotel’nikov Vladimir N.
Published: November 2020

Modern scientific literature contains few reports concerning the influence of target therapy on pathogenetic factors of autoimmune thyroid diseases (AITD). Despite a large number of hypotheses of AITD pathogenesis, the only well established fact is the starting stage of Graves disease (GD) and autoimmune thyroiditis (AIT) is the loss of tolerance to thyroid autoantigens and the final stage is production of autoantibodies to them. Up to 75-80% of the patients with GD have antibodies against thyroid peroxidase and only few of them have anti-thyroglobulin antibodies more characteristic of AIT. Thyrotropin releasing hormone (TRH) is known to stimulate T-lymphocyte production via local effect on insulin-like growth factor (IGF). Modern studies confirm the important role of cytokines in immunopathogenesis of GD and AIT. Moreover, excess activation of this system in AITD provides a basis for the development of specific therapeutic approaches to personified pharmacotherapy. The effectiveness of anti-cytokine therapy of GD and AIT was demonstrated in animal experiments. Studies of therapy targeted on orbital and thyroid autoantigens in AITD are currently underway. The existence of specific receptors and the ability of immunocompetent cells to produce neuropeptides create prerequisites for their participation in intercellular cooperative processes. It can be supposed, by analogy with the influence of hormones and neuromediators on immunocytes, that neurohormones act on them via specific receptors with the involvement of cyclic nucleotides. It opens up opportunity for targeted correction of these relationships. Further studies of immunopathogenetic mechanisms of GD and AIT for better understanding the role of interaction between inborn and acquired immunity, its regulation, and intersystem transmission of signals in the development of these diseases are needed to realize modern strategies of their target therapy.
Primary angiitis of central nervous system with cephalic syndrome
Authors: Starikova Natal’ya L. , Zalomova E. V.
Published: November 2020

A man aged 37 years experienced recurrent episodes of intensive headache. MRI revealed multiple symmetric lesions in brain. Systemic vasculitis, reversible cerebral vasoconstriction syndrome and migraine were excluded. Primary angiitis of central nervous system was diagnosed. The patient’s condition rapidly improved on corticosteroid therapy.
Phenomenon of unstable international
normalized ratio on warfarin therapy (clinical and genetic aspects).
Authors: Derugin Mikhail V. , Zadvorev S. F. , Obrezan A. G. , Filippov A. E. , Grishaev S. L.
Published: November 2020

One of the most important problems in the modern coagulation is the issue of choosing the optimal drug for a long-term oral anticoagulation therapy. Research results of the last 5-10 years show that the reasonable choice between vitamin K antagonists (VKA) and non-vitamin K-dependent oral anticoagulants (NOAC) can be made. The following article describes the phenomenon of «labile INR» on warfarin therapy and describes its clinic and hereditary determinants. Our data about the clinical testing toassess the risk of "labile INR" based on the scale of the Russian populat ion demonstrate potential benefits from setting the scale into the clinic. It is shown that Clinical SAMe-TT2R2 scale correlates with the duration of achieving the target INR, and the patients with the SAMe-TT2R2 score of 4 or more are in the group of iatrogenic complications risks. The contribution of genetic and clinical factors to INR dynamics at the start of therapy in different groups of patients, according to their sensitivity to warfarin therapy and potential duration, is discussed in the article. The results obtained by the analysis of «labile INR» factors will help a doctor to make a choice of anticoagulant between the NOAC and VKA.
Proinflammatory mediators and gene polymorphism of ММР1 and ММР12 in post-traumatic knee osteoarthritis.
Authors: Panina Svetlana B. , Krolevets I. V. , Milyutina N. P. , Ananyan A. A. , Zabrodin M. A. , Vnukov V. V.
Published: November 2020

Joint injury is a well-established risk factor for development of post-traumatic knee osteoarthritis (PTOA) and may lead to joint inflammation. The aims of the study were: the investigation of proinflammatory mediators - the levels of IL-1β and uric acid (UA), the activity of xanthine oxidoreductase (XOR) - in the plasma and synovial fluid (SF) of patients with PTOA; the search for putative predictors of progression and predisposition to the PTOA development among these mediators and polymorphic gene loci of matrix metalloproteinases (MMP) - rs1799750 ММР1 and rs2276109 ММР12. Patients with a radiographically diagnosed PTOA (Kellgren-Lawrence, K/L grades I-III, N = 71) and 44 healthy controls were enrolled in the study of the levels of proinflammatory mediators. The XOR activity was measured by quantitation of uric acid accumulation at 293 nm as a result of xanthine oxidation. The uric acid level was determined using a commercially available kit (“Vital”, Russia) and spectrophotometer. The level of IL-1β was measured using commercially available enzyme-linked immunosorbent assay (ELISA) kit (“Vector-Best”, Russia) according to the manufacturers’ instructions. We used PCR followed by agarose gel electrophoresis (“SNP-Express” kits, “Lytech”, Russia) for SNP-genotyping. The XOR activity, the levels of proinflammatory mediators uric acid and IL-1β were determined to be significantly increased in the plasma of PTOA patients - by 20% (p = 0,03), 49% (p = 0,009) and 41% (p = 0,044), respectively. Multiple regression adjusted for age, gender, BMI of patients showed that xanthine oxidase activity was a significant predictor of radiographic knee osteoarthritis (β = 0,373, p < 0,01). Genetic analyses of 184 patients with PTOA and 113 healthy controls demonstrated that G-allele of polymorphic locus A-82G ММР-12 was associated with higher risk of post-traumatic knee osteoarthritis development (OR = 1,803, p = 0,028). The -82G-allele of ММР-12 may abrogate angiostatic effect of MMP-12 by decreasing its expression and promote activated macrophage recruitment and degradation of the cartilage.
Plague epidemic in Moscow (1770—1772).
Authors: Simonenko V. B. , Abashin Victor G. , Dulin P. A.
Published: November 2020

Materials on plague epidemic in Moscow at the end of the XVIII century are provided: the reasons of emergence and development of epidemic of plague in Moscow, actions of authorities and doctors of the capital for liquidation of epidemic. The chronology of development and elimination of epidemic is given. The role of a medical personnel of the Moscow military hospital in detection of a disease and prevention of its distribution is shown. It is shown a role of the Count Grigory Orlov in liquidation of epidemic of plague and suppression of "a plague revolt".
Relationship of the manifestations of chronic obstructive pulmonary
disease blood levels of the hormones of the adrenal cortex.
Authors: Pavlova O. V. , Kichigin V. A. , Kochemirova Tatiana N.
Published: November 2020

The blood content of adrenal cortex hormones in patients with chronic obstructive pulmonary disease was studied. The decrease in the concentration of dehydroepiandrosterone sulfate and the tendency to the growth of aldosterone and cortisol. It is noted a direct relationship of the content of dehydroepiandrosterone sulfate with the function of external respiration, saturation of arterial blood and the opposite-with the severity of cough and dyspnea, and BODE index ADO.
The values of the modified
bronchodilation test glycopyrronium to identify the reversibility of bronchial obstruction in patients with chronic obstructive pulmonary disease.
Authors: Sharova Natalia V. , Cherkashin D. V. , Grishaev C. L. , Kutelev G. G. , Chumakov A. V.
Published: November 2020

Proposed modification of a bronchodilation test with sequential use of rapidly acting bronchodilators: anticholinergic actions glycopyrronium bromide 50 μg and β2-agonist - salbutamol 400 mcg in patients with stable COPD. Modified bronchodilatation test (MBT), was performed in 48 patients with stable COPD, revealed signs of reversible bronchial obstruction more often than the standard BDT (in 76% of cases, against 25% in primary and 36% in the control groups, respectively). The magnitude of the bronchodilator effect glycopyrrolate, defined on spirometry, comparable to that in sbdt in patients with COPD. The degree of increase in FEV1, FVC, POS patients after MDT was significantly higher than that in the standard theatre (sbdt), which confirms the synergistic effect of double bronchodilatation. Holding mbdt is recommended for detection of reversibility of bronchial obstruction in patients with COPD.
The possibility of applying magnetic resonance imaging with hepatospecific
contrast agent.
Authors: Lomovtseva Karina K. , Karmazanovsky G. G.
Published: November 2020

Nowadays, it is difficult to overestimate the role of cross-sectional imaging in the diagnosis of focal and diffuse liver diseases. In magnetic resonance imaging (MRI) there is a unique opportunity to use hepatospecific contrast agents compared with other visualization techniques. Gadoxetic acid is a hepatospecific magnetic resonance contrast agent which has the extracellular contrast agent properties and hepatotropic property. About half of the administered dose of gadoxetic acid enters into functioning hepatocytes through cell membrane transporters and then is excreted into the bile ducts and sinusoidal space. The obtained hepatobiliary phase provides information about the structural features of the focal liver lesions, improving their detection and differential diagnosis. In addition it allows to assess the anatomical and functional conditions of the hepatobiliary system. This article describes clinical applications of MRI with gadoxetic acid and its benefits, visualization principles of different focal liver lesions in hepatobiliary phase and features of the obtained images.
The influence of cytoflavin staged therapy on dynamics of
laboratory values in professional athletes during first stage of preparation for the game season.
Authors: Achkasov E. E. , Kurshev V. V. , Zaborova V. A. , Nebozhaeva Svetlana F.
Published: November 2020

The observation program was attended by 50 professional hockey players, divided into 2 groups, respectively, teams (25 people).The participants of the main group received step therapy with cytoflavin: first intravenously drip 10 ml of the drug diluted in 200 ml of 5% glucose solution, for 10 days, then 2 tablets 2 times a day for 25 days. Pharmacological support of participants in the comparison group were excluded the preparations of succinic acid or other metabolic means. Laboratory parameters were evaluated in dynamics: before the training (point 1), in the middle of the preparatory stage (point 2) and 35 days after the start of training (after the entire course of step therapy) (point 3). According to the results of the study revealed that the parameters of red blood (number of red blood cells, hemoglobin level, average red blood cell volume, average hemoglobin content in the red blood cell (MCH), the average concentration of hemoglobin in the red blood cell (MCHC) were more stable against the background of the use of cytoflavin, and the values of aspartataminotransferase and creatinine decreased during the observation in the main group and increased in the comparison group so that at the point 3 level aspartataminotransferase (AST) in the main group became significantly lower than in the comparison group (p=0.039*), and the level of creatinine was equal at initially higher rate in the main group (p= 0.012*). MB - fraction of creatine phosphokinase (MB-CPK) in the blood decreased in the main group of athletes (in the evaluation test of Pillai p=0,004), did not significantly change in the comparison group. There were no significant differences in the indicators of cortisol and testosterone between the groups, although the level of cortisol decreased in the athletes of the main group, and testosterone - increased, while in the comparison group the situation was the opposite. By the end of the follow-up, a statistically significant decrease in lactate levels before and after training was revealed in the group of athletes taking cytoflavin.
Cardiovascular complications in patients with rheumatic diseases.
Authors: Arshinov A. V. , Emanuilov V. I. , Maslova I. G.
Published: November 2020

In the recent years, there are more and more reports stating an increased risk of atherosclerosis and cardiovascular complications in patients with rheumatic diseases. It should be noted that the development of atherosclerosis in this category of patients occurs much earlier than in the general population. Indeed, many rheumatic diseases are associated with an increased risk of developing of cardiovascular diseases and death from vascular accidents, including RA, systemic lupus erythematosus, ankylosing spondylitis, gout, psoriatic arthritis, vasculitis of the middle and large vessels. There are reports of an increased risk of cardiovascular disease in patients with systemic scleroderma. It is significant that rheumatic diseases and coronary heart disease combine common pathophysiological mechanisms - systemic and chronic inflammation. At the same time, traditional risk factors such as hypertension, old age, smoking, hypercholesterolemia, obesity and male sex can not fully explain the mechanism of accelerated development of atherosclerosis in patients with rheumatic diseases. The presence of specific risk factors, such as the duration of the course of treatment, glucocorticosteroids administration, the presence of an increased concentration of inflammatory mediators and autoimmune mechanisms create conditions for the acceleration of atherosclerosis in this group of patients. Coordination of efforts of rheumatologists and cardiologists in studying the mechanisms of accelerated development of atherosclerosis in patients with rheumatic diseases will allow to develop adequate methods for timely diagnosis and prevention of cardiovascular complications in patients with this widespread pathology.
Unusual nuclear
form hairy cells in hairy cell leukemia discovered using a lymphocyte-binding anti-CD antibody microarray.
Authors: Khvastunova A. N. , Al-Radi L. S. , Fedyanina O. S. , Ataullakhanov F. I. , Vorobiev A. I. , Kuznetsova S. A.
Published: November 2020

Hairy cell leukemia (HCL) is a chronic lymphoproliferative disorder constituting about 2% from all leukemia cases and characterized by typical “hairy” morphology of tumor lymphocytes. We describe an HCL case with atypical nuclear shapes (lymphocytes with clover-leaf-like, horse-shoe-like, ring-shaped nuclei and binuclear cells were present). Morphology and immunophenotype of circulating leukemic cells were studied using a cell-binding microarray - a transparent plastic slide with immobilized monoclonal antibodies against surface antigens of lymphocytes. The cell-binding microarray with immobilized anti-CD11c, anti-CD103 and anti-CD123 permits to study a lymphocyte population enriched with hairy cells. Hairy cells with atypical nuclei constituted 3% of all lymphocytes and 15% of all hairy cells. This unusual hairy cell morphology is the first described in Russia and was found in one out of 85 HCL cases in our practice.
Results of application of a new method for the treatment of hallux valgus of the first toe
Authors: Brizhan’ L. K. , Boichenko A. V. , Davydov D. V. , Solomin L. N. , Kerimov A. A. , Sheyanova Elena Y. , Tyul’kin E. O. , Belokrylova M. S.
Published: November 2020

Background. The aim of the present article was to report our experience with the treatment ofpatients with hallux valgus and to perform comparative analysis of the results of the newly proposed and standard methods for its surgical correction. Methods. The data on 70patients (101 feet) with hallux valgus that were operated on between 2011 and 2015 in St. Petersburg Hospital No 2 using the new and standard methods were analysed. The functional assessment (AOFAS score) and X-ray examination were performed preoperatively, 3 and 12 months after the procedure. Comparative analysis between patients undergoing surgical correction by the new and standard methods has been undertaken. Results. We did not find any significant difference between the two groups in mean AOFAS score 12 months after surgery. Nevertheless, the function score of the patients treated by the newly proposed method (79.4±6.5 in 3 months) was significantly better than in those given the standard treatment (72.2±7.6 in 3 months). Mean intermetatarsal angle 12 months after surgery by standard and new methods was 9,7±0,7° and 8,6±0,7° (p<0.05), mean metatarsophalangeal angle 13,6±0,9° and 13,0±1,1° (p<0,05) respectively. Conclusion. According to the data obtained, the original method of hallux valgus surgical correction allows to improve its functional and x-ray results.
Servicios Ecosistémicos: Implementación de metodologías específicas para una correcta valoración
Authors: López Solano Cristian Alexis
Published: November 2020

Actualmente nuestro sistema jurídico colombiano contempla algunos mecanismos en materia derecho ambiental que propende por la protección del medio ambiente; dicha protección resulta insuficiente a la luz de las necesidades vigentes que reclama la naturaleza en todo el territorio nacional.

 

Con frecuencia, la valoración económica ambiental que se hace dentro de un proyecto económico de alto impacto (sea el que sea) es subjetiva pues la normatividad y reglamentos aplicables para este tipo de procesos, es general. Por lo mismo, resulta insuficiente su aplicación y además improbable la consecución de sus finalidades.

 

La valoración de servicios ecosistémicos se ha convertido en un elemento confeccionado por el autor del proyecto económico (es decir, el particular o empresario), por lo mismo, en la balanza de juicio resulta siempre favorecido el beneficio económico sobre el beneficio ambiental. Tal es la suerte de las guías y metodologías que para el efecto ha instaurado el gobierno nacional, pues al ser generales, favorecen un amplio margen de discrecionalidad en la confección del diagnóstico ambiental que consecuencialmente produce una valoración indebida y además, irreal.
Inteligencia Artificial aplicada a la Justicia
Authors: Florez Hernandez Isabel Cristina
Published: November 2020

Este artículo permite un mayor acercamiento a los desafíos que generan los grandes avances tecnológicos que ha venido experimentando la sociedad de América Latina y de manera puntual Colombia en temas tan delicados como la Justicia. Para ello se deberá primero analizar el incremento que se ha dado a lo largo de los últimos años a casos que revisten alta importancia y complejidad como es el caso, por ejemplo, de las Acciones de Tutela, que se dan cuando un derecho ha sido vulnerado, y en la gran mayoría de los casos, dicha violación se da en derechos fundamentales  de tanta trascendencia como la vida misma, lo que ha significado que escenarios como la Corte Constitucional evidencien una tendencia al congestionamiento, registrando cifras que más que comprobar dicho aumento, lo que hacen es generar una alerta de gran magnitud sobre la eficacia y eficiencia de la Justicia en Colombia, específicamente. Segundo, deberá considerarse como una herramienta basada en Inteligencia Artificial y Blockchain como es el caso de Prometea, se muestra como una alternativa que aporta no solo un alivio en términos de disminución en el tiempo establecido para la atención de los casos que están ya en espera de obtener una solución, y que corresponden básicamente a casos fáciles y que ya han sido gestionados previamente, sino una alta eficiencia, al registrar por ejemplo, el trabajo que a una persona le tomaría horas ejecutarlo y en cambio a Prometea le tomaría minutos procesar. Tercero y no menos importante, se deberá generar conciencia que si bien es cierto, el proyecto de Inteligencia artificial se convierte en un alivio, también debe tenerse presente que deberá bajo todos los puntos de vista, contarse con la revisión y auditoria de parte de un funcionario, que avale la eficacia del trabajo desarrollado por este aplicativo.

La tecnología, como ya sabemos, no deberá ser vista como el reemplazo de la mano de obra del ser humano en la ejecución de un trabajo sino que deberá significar un aliado que contribuirá siempre a que esta labor se desarrolle de manera más eficiente y precisa, sin olvidar que la responsabilidad en la función que se ejecuta solo podrá estar en cabeza del hombre, aun cuando las máquinas y sus diferentes funcionalidades nos faciliten cada día más las cosas.

Por último es importante precisar que la implementación de este tipo de instrumentos deberá siempre ir de la mano, de la preocupación por no deshumanizar los procesos al interior de la Justicia, pues si bien es cierto, quien más se beneficia es esta misma, no podrá hacerlo a costa de los intereses, garantías y beneficios propios del ciudadano receptor de dicha gestión judicial.
Adaptar la herramienta de gestión Cuadro de Mando Integral para lograr una mejor implementación de la metodología Lean Construction en el grupo de procesos de planificación de la gestión del tiempo en proyectos de oficinas del sector privado de Lima
Authors:   ,   Universidad Peruana de Ciencias Aplicadas (UPC), Caceres Olivos Joaquín Daniel , Toda Luna Alejandra Gianella
Published: November 2020

La metodología Lean Construction (LC) en numerosas literaturas internacionales, ha demostrado grandes beneficios en la planificación de proyectos de construcción. Sin embargo, recientes investigaciónes y casos de proyectos emblemáticos en Perú mencionan que esta metodología ha tenido dificultades al momento de ser implementada. Una serie de factores, que han sido identificados en la presente investigación, son responsables de una implementación lenta e ineficiente en la obtención de los objetivos esperados. La presente tesis identifica los factores que impiden la correcta implementación de LC en el grupo de procesos de planificación de la gestión del tiempo tomando en cuenta el análisis de tres proyectos de oficinas del sector privado en la ciudad de Lima. En dicho análisis, se recopila información y se realizan encuestas en cada uno de los proyectos analizados para poder identificar dichos factores, los cuales mayormente mencionan problemas de comunicación y desconocimiento de las herramientas LC por el equipo del proyecto. El objetivo del presente estudio es mejorar la implementación de Lean Construction en el grupo de procesos de planificación de la gestión del tiempo en proyectos de oficinas del sector privado en Lima, a través del uso del Cuadro de Mando Integral adaptado a fin de reducir costos y plazos adicionales en los proyectos. Esta herramienta fue evaluada y validada por ingenieros civiles y expertos en la materia.
Sm-Nd isotopy of the dykes of the Vorontsovskoe gold-ore deposit (Northern Urals)
Authors:   Institute of Geology and Geochemistry UB RAS, Azovskova O. B. , Soroka E. I. , Rovnushkin M. Yu. , Soloshenko N. G.
Published: November 2020

The Vorontsovskoye gold-ore deposit (Northern Urals) generally corresponds to the Carlin-type. One of the deposit features is the presence of numerous dykes of mafic and middle chemical composition, of normal and increased alkalinity. Sm-Nd isotope studies for the first time confirmed the dykes formation age 340 ± 35 Ma. These data can be indicative of the post-collisional stage of magmatism in this area. The positive Nd values suggest a probable abyssal magmatic source of Nd.
Sulfur isotope composition of secondary Ru-Os-Ir sulfides and sulfoarsenides from the Verkh-Neivinsk dunite-harzburgite massif (Middle Urals)
Authors:   Institute of Geology and Geochemistry UB RAS, Murzin V. V. , Badanina I. Yu. ,   Institute of Geology and Geochemistry UB RAS, Malitch K. N. ,   Institute of Geology and Geochemistry UB RAS, Ignatiev A. V. ,   Far East Geological Institute FEB RAS, Velivetskaya T. A. ,   Far East Geological Institute FEB RAS
Published: November 2020

Limited data on the isotopic composition of sulfur of platinum-group minerals (PGM) are reported in the literature. The LA-ICP-MS method was used to study the S-isotopic composition of Ru-Os-Ir sulfides and sulfoarsenides forming secondary corrosion and superimposed PGM assemblages from placer deposit of the East Shishim river occurring within the Verkh-Neivinsky dunite-harzburgite massif. Sulfides from corrosion PGM assemblage (laurite, As-containing laurite) replace the grains of primary native Os and Ru minerals, forming rims on them. PGM from superimposed assemblage (laurite, irarsite, tolovkite, etc.) originated on the surface of laurite rims that form part of corrosion PGM assemblage. Variations in 34S values of secondary PGM (from –4.6 to 7.6 ‰) are more pronounced than those for laurite and erlichmanite from primary PGM assemblage (i. e., 0.2—2.3 ‰). The results are consistent with a model of the ultramafic massif ascending to the surface and subsequent water metamorphism during the tectonic flow and crust-mantle interaction. At the initial stage of metamorphism, mantle sulfur is present, isotopically lightened under oxidation conditions and temperature reduction. The final stage is marked by sulfur of the metamorphic fluid formed by the involvement of isotopically-heavy sulfur derived from the host sedimentary rocks.
Material composition of Lower Triassic sandstones from the northern areas of the Timan-Pechora oil and gas province
Authors:   Institute of Geology FRC Komi SC UB RAS, Timonina N. N.
Published: November 2020

Recently various authors paid much attention to accessory minerals of clastic rocks to clarify the composition of the source area and formation conditions of terrigenous deposits. The paper describes some minerals of the heavy fraction of Triassic sandstones in the north of the Timan-Pechora oil and gas province (garnet, epidote, chromium spinels, ilmenite, etc.). We showed that the enrichment of sandstones with various mineral grains was controlled by not only the composition of the eroded rocks, but also by the hydrodynamics of the flow, as well as the method of transfer of clastic material. We noted that the features of heavy fraction minerals could be used to reconstruct sedimentation environments, taking into account their physical and chemical properties, distribution of minerals by fractions, and their stability during transportation.
Crystallization features of calcium sulfate in the process of “artificial aging”
Authors:   ZAO Ural-Omega, Garkavi M. , Fischer H.-B. ,   Weimar University of Civil Engineering, Kolodezhnaya E. ,   IPKON RAS
Published: November 2020

Gypsum binders are widely used in construction, mining and the oil and gas industry. The use of these binders is conditioned by stability of their technical characteristics, which is achieved by using a technological operation “artificial aging”. The features of artificial aging are: 1) hydration of calcium sulphate hemihydrate in liquid phase deficiency; 2) the resulting dihydrate gypsum crystallizes in a limited volume of micropores of the original binder. From the standpoint of the quataronic concept, the features of the crystallization of gypsum dihydrate in the micropores of the original gypsum binder are considered. The effect of artificial aging conditions and the degree of supersaturation on the growth mechanism and the morphology of gypsum dihydrate crystals was determined. The use of artificial “aging” results in healing of defects in the structure of the original binder, decreasing water demand and increasing strength.
PSYCHOLOGICAL CONSEQUENCES OF THE INFLUENCE OF HIGH-INTENSITY STRESSORS OF DIFFERENT TYPES
Authors:   FSBIS «Institute of psychology of the Russian academy of sciences», Kharlamenkova Nataliya E. , Nikitina Dariya A. ,   FSBIS «Institute of psychology of the Russian academy of sciences»
Published: November 2020

The article is devoted to the study of delayed (post-traumatic) stress caused by different types of stressful situations (death of a loved one, life-threatening diseases, traffic accidents, situations of physical and emotional violence) during early adulthood, the analysis of specific psychological markers of its intensity. The study involved 509 people (232 men and 277 women) aged 17 to 35 years (Me = 21; SD = 4,3). Methods: Posttraumatic Stress Disorder Checklist (PCL-5) in the Russian-language adaptation by N. V. Tarabrina and co-authors for the diagnosis of stressful events and their psychological consequences; the list of stress situations contained in the Life Events Checklist (LEC-5) for DSM-5; the Symptom Check List-90-r-Revised (SCL-90-R) technique in the Russian-language adaptation by N. V. Tarabrina and co-authors was used to evaluate psychopathological symptoms. It has been shown that the most severe in intensity posttraumatic stress causes situations that pose a threat to the physical and psychological well-being of a person at the same time (violence and life-threatening disease). Taking into account the level of mental trauma and the type of stressor, an analysis of a number of features of psychopathological symptoms was carried out. The results of the study made it possible to identify markers of severe post-traumatic stress, which were indicators of violation of contact with reality, expressed in distancing a person from the surrounding reality, distrust of the world, suspicion, phobic anxiety.
VIRTUAL REALITY AS A DISCURSIVE ENVIRONMENT THAT AFFECTS THE FORMATION OF A PROFESSIONAL ETHOS OF MEDICAL STUDENTS
Authors:   FSBEI HE «Tver state medical university», Grigoreva Dariya D. , Mikheev Mikhail I. ,   FSBEI HE «Tver state technical university», Potamskaya Vera P. ,   FSBEI HE «Tver state technical university», Bashilov Roman N. ,   FSBEI HE «Tver state medical university», Bashilova Svetlana M. ,   FSBEI HE «Tver state medical university»
Published: November 2020

The article examines the problem of the influence of virtual reality and digital society on the formation of the professional ethos of medical students. Undoubtedly, the totality of digital society, its diffusion into all spheres of existence determines the formation of a person's identity in personal, social and practical modes. At the same time, due to its Biophysics, medical activity is focused on practical activities and direct communication. Virtual reality creates conditions for any person, including students, to form an ideal narcissistic projection that exists within and according to the laws of digital society. The abstractness of the ideal Self comes into conflict with the real Self, creating new ways of alienation and hitherto unseen modes of meaning-loss and existential trauma. In addition, virtual reality limits the content of the communication process, reduces it, formalizes it, and restricts it with artificial rules. The article describes the basic content concepts through which the issues of digital society are denoted. The study sample is fairly uniform and includes 116 TvSMU students aged 19 to 22 years. The article presents data from descriptive statistics and psychodiagnostic techniques. The analysis conducted between the indicators of meaning-life orientations of the individual, the subjective feeling of loneliness and the status of ego-identity, allows us to conclude about the formation of the phenomenon of self-alienation, loss of meaning and existential trauma. The formation of professional identity is a complex symbiotic process that involves qualitative changes and a transition to a new worldview level. It is during this period that the student's psyche is most labile and subject to external influence. The dichotomy of the virtual and the real affects the formation of personality, depriving this process of concreteness and violating the integrity of the socio-cultural and professional thesaurus.