Gender differences in the perception of leptospirosis severity, behaviours, andLeptospiraexposure risk in urban Brazil: a cross-sectional study
Authors: Delight Ellie A. , Santiago Diogo César de Carvalho , Palma Fabiana Almerinda G. , de Oliveira Daiana , Souza Fábio Neves , Santana Juliet Oliveira , Hidano Arata , Alzate López Yeimi Alexandra , Reis Mitermayer Galvão G. , Ko Albert I. , Marphatia Akanksha A. , Cremonense Cleber , Costa Federico , Eyre Max T. 
Published: April 2024

Background

Vulnerability to climate hazards and infectious diseases are not gender-neutral, meaning that men, women, boys, girls, and other gender identities experience different health risks. Leptospirosis, a zoonotic climate sensitive infectious disease, is commonly transmitted to humans via contact with animals and the environment, particularly soil and flood water. Gender differences in leptospiral infection risk are reported globally, with men consistently found to be at higher risk than women. However, the drivers of this difference in risk are poorly understood. Previous studies suggest that the interplay of knowledge, perceptions, and behaviours may shape differential infection risk among genders.

Methodology/Principal Findings

To examine gender differences inLeptospiraexposure risk we conducted a cross-sectional serosurvey among adult participants (n = 761) in four urban, marginalised, informal settlements in the city of Salvador, Brazil. We found that seroprevalence was 14.6% and 9.4% across men and women respectively. We then applied causal inference methodology to a two-part sex-disaggregated analysis to investigate: 1) the association of perceptions and behaviours withLeptospiraseropositivity and 2) the association of perceptions with behaviours. We found that men who perceived leptospirosis as extremely serious had lower odds of seropositivity, walking through sewage water, or walking barefoot, suggesting an important link between perceptions, behaviours, and exposure risk. These associations were not found in women, and these behaviours were not associated with seropositivity in men or women.

Conclusions

Our results highlight perceived severity of disease as a potential driver of behaviour in men, and perceptions of disease may be an important target for health education programs. Furthermore, our study identifies evidence gaps in the understanding of infection risks in women. As the first sex-disaggregated study investigatingLeptospirainfection risks, we advocate for a gendered lens in future studies to further understand risks specific to different gender identities.

Author summary

Leptospirosis is a wide-spread zoonotic pathogen commonly spread from rodents to humans in urban informal settlements vulnerable to flooding in Salvador, Brazil. Gendered cultural norms shape perceptions of leptospirosis, behaviour, and subsequent exposure at the human-animal-environment interface. Despite this, there is limited research investigating gender-determined infection risks. Therefore, our study investigated associations of risk factors forLeptospiraseropositivity in men and women. We identified perceived severity of leptospirosis, high-risk occupations, and age as significant risk factors in men. We also investigated perceived severity as a driver of risk by estimating the association of perceived severity with behaviours. We found that greater perceived severity was associated with reduced odds of walking through sewage water and walking barefoot outside of the home in men, however this behaviour was not significantly associated with reduced odds of leptospirosis. Our results suggest evidence gaps in the understanding of transmission routes in women. As the first sex-disaggregated study investigating gender-determinedLeptospiratransmission routes, our findings illustrate the importance of gendered behaviours, perceptions, and risk as drivers of leptospirosis, and highlight the need for further research to understand exposures more prevalent in women. We advocate for a greater focus on gender to help unravel gender-determined infection risks.