bluuebunny/crossref_metadata_2025 huggingface dataset:
Trust in Science and COVID-19
Authors: Mousoulidou Marilena , Christodoulou Andri , Argyrides Marios , Siakalli Michailina , Constantinou Louiza
Published: March 2022

In this entry, trust in science is defined as the reliance, confidence, and dependence on science to understand scientific information. With the outbreak of, and the uncertainty surrounding the COVID-19 pandemic, turning towards science and trusting the specialized knowledge of experts is of particular importance during this period.
Secondary Succession after Slash-and-Burn Cultivation in Papuan Lowland Forest, Indonesia
Authors: Murdjoko Agustinus , Brearley Francis Q. , Ungirwalu Antoni , Djitmau Dony A. , Benu Nithanel M. H.
Published: March 2022

Papuan forests have been subjected to shifting cultivation for centuries by indigenous people affecting the ecological processes therein; during secondary succession, fallow forests recover naturally. However, the information on ecological succession after swidden practices remains poorly understood in Papuan lowland forests. This study aimed to examine the plant species richness and density of different plant lifeforms in fallows of increasing time after slash-and-burn cultivation along with basic edaphic factors. We performed data collection in the northern part of the lowland evergreen tropical forest near Manokwari, West Papua, Indonesia. The sampling consisted of 26 plots distributed in the primary forest (n = 6) and in secondary/fallow forests 2-, 4-, 7-, and 9-years after cultivation (n = 5 for each age class). The plant community in primary forest clearly differed from the secondary forests. The plant species richness was about twice as high in primary compared to secondary forests. The density of trees and shrubs increased during succession whereas that of lianas declined. The soil fertility declined in secondary forests, although soil organic matter was greatest two years after swidden and then decreased gradually over time. This research underlined that indigenous swidden practices alter ecological conditions and that secondary forests will take a long time to fully recover to resemble primary forest. Hence, the monitoring of vegetation during the process is necessary to inform conservation programs.
Between Biodiversity Conservation and the Supply for Broadleaved Wood: A Case Study of State Forests National Forest Holding (Poland)
Authors: Wysocka-Fijorek Emilia , Gołos Piotr , Janeczko Krzysztof
Published: March 2022

Climate change is an important issue that increasingly affects our lives. One of the proposals for mitigating climate change is fighting biodiversity loss, which can support climate mitigation and adaptation actions. In Poland, the possibility of excluding large tracts of forest areas from use is being considered. The discussed the exclusion of forest land from use will affect the timber supply and market, especially for broadleaved wood. The main purpose of this analysis is to present a timber supply forecast, with a particular focus on the possibility of obtaining broadleaved hardwood timber in Poland from forests managed by State Forests National Forest Holding under three scenarios that assume different criteria for selecting forest areas for protection. The work was divided into two main phases: (1) the analysis of historical sales volume of wood products and average sale prices of hardwood during the period 2011–2020; (2) the preparation of a forecast of the potential possibility of maintaining broadleaved hardwood production in the three decades between 2020 and 2049. In the forecast, it was assumed that about 2.7 million hectares of planted and production forests are excluded from use in order to implement the provisions of the 2030 Biodiversity Strategy. In Scenario “I”, the supply of merchantable broadleaved roundwood volume will be reduced to 14%–18% that of Scenario “0”. In Scenario “II”, 55% of the “0” scenario is harvested, and in Scenario “III”, 33%–37% of the “0” scenario merchantable broadleaved roundwood is harvested. The introduction of restrictions on timber harvesting as a result of Poland’s compliance with European Union requirements in the area of environmental protection will lead to a significant reduction in the supply of timber on the market. This may lead to a further increase in timber prices and an increase in the importance of large timber buyers at the expense of local buyers. The recommendations contained in the policy objectives that the EU sets for the states should be supported by a thorough analysis when selecting areas for strict protection.
Optimisation of Xylanase–Pectinase Cocktail Production with Bacillus amyloliquefaciens ADI2 Using a Low-Cost Substrate via Statistical Strategy
Authors: Nawawi Muhammad Hariadi , Ismail Khairul Izdihar , Sa’ad Norazliza , Mohamad Rosfarizan , Tahir Paridah Md , Asa’ari Ainun Zuriyati , Saad Wan Zuhainis
Published: March 2022

An effective statistical tool for increasing and boosting the production of xylanase and pectinase by Bacillus amyloliquefaciens ADI2 during submerged fermentation (SmF) appears to be the response of surface methodology (RSM) using the central composite design (CCD). Optimum production was achieved under fermentation conditions of a temperature of 28 °C, pH of 8.38, inoculum size of 4% (w/v) and agitation speed of 94 rpm for 48 h. The experimental responses demonstrated a near agreement with the expected responses under optimum conditions of independent variables, suggesting the model’s validity. The optimised CCD model had a 1.34-fold, 159 ± 6 U/mL greater xylanase and 5.96-fold, 205 ± 9 U/mL greater pectinase production than the one factor at a time (OFAT) approach. The production of concurrent enzymes of xylanase–pectinase resulted in a ratio of 1:1.3.
The Volatile Compounds and Aroma Description in Various Rhizopus oligosporus Solid-State Fermented and Nonfermented Rice Bran
Authors: Astuti Retno Dwi , Fibri Dwi Larasatie Nur , Handoko Dody Dwi , David Wahyudi , Budijanto Slamet , Shirakawa Hitoshi , Ardiansyah Ardiansyah
Published: March 2022

Rice bran is known to have beneficial nutrients. Current studies suggest that solid-state fermentation affects the rice bran’s volatile profile. The aim of this study is to identify the volatile compounds and aroma description of fermented and nonfermented rice bran (FRB and NFRB) of Ciherang, Inpari30, IR64 and Inpari42. The fermentation was conducted using Rhizopus oligosporus solid-state fermentation. Headspace-solid phase microextraction coupled with GC/MS was performed, and the aroma was translated by 10 trained panelists through quantitative descriptive analysis (QDA). The result showed that 72 and 68 compounds were identified in FRB and NFRB, respectively. They are aldehydes, ketones, alcohols, acids, esters, fatty acid, phenol, benzenes, furan, thiazole, pyrazines, pyridine, lactones, terpenes, and hydrocarbons. The PCA showed that FRB was dominated by alcohols, whereas NFRB was dominated by aldehydes. The QDA described nine aromas, i.e., rancid, smoky, musty, grassy, green, earthy, cereal, and sweet in NFRB. The fermentation process added fermented attributes to the aroma description to FRB and enhanced the rancid, smoky, and musty aromas. These studies indicated that fermented rice bran might increase the volatile compound of rice bran. Thus, it may provide opportunities to develop the production of fermented rice bran as a functional ingredient.
Recovery and Purification of Fumaric Acid from Fermented Oil Palm Empty Fruit Bunches Using a Simple Two-Stage Precipitation Procedure
Authors: Boondaeng Antika , Khanoonkon Nattaporn , Vaithanomsat Pilanee , Apiwatanapiwat Waraporn , Trakunjae Chanaporn , Janchai Phornphimon , Niyomvong Nanthavut
Published: March 2022

Oil palm empty fruit bunches (EFBs) are an attractive lignocellulosic material that can be used as a cheap renewable feedstock to produce organic acids and many other value-added products. This research is aimed at investigating the potential of steam-exploded oil palm EFBs for the production of fumaric acid, a food additive widely used for flavor and preservation, through a separate hydrolysis and fermentation process using the selected fungal isolate Rhizopus oryzae K20. To develop an efficient method for the recovery and purification of fumaric acid from fermented oil palm EFBs, a two-stage precipitation protocol was employed, followed by an activated carbon-mediated polishing step to remove contaminants. After these two processes were accomplished, a recovery yield of 81.2% and a purity of 83.5% were achieved.
Investigation of Using CAPTCHA Keystroke Dynamics to Enhance the Prevention of Phishing Attacks
Authors: Alamri Emtethal K. , Alnajim Abdullah M. , Alsuhibany Suliman A.
Published: March 2022

Phishing is a cybercrime that is increasing exponentially day by day. In phishing, a phisher employs social engineering and technology to misdirect victims towards revealing their personal information, which can then be exploited. Despite ongoing research to find effective anti-phishing solutions, phishing remains a serious security problem for Internet users. In this paper, an investigation of using CAPTCHA keystroke dynamics to enhance the prevention of phishing attacks was presented. A controlled laboratory experiment was conducted, with the results indicating the proposed approach as highly effective in protecting online services from phishing attacks. The results showed a 0% false-positive rate and 17.8% false-negative rate. Overall, the proposed solution provided a practical and effective way of preventing phishing attacks.
Fractional Modeling Applied to the Dynamics of the Action Potential in Cardiac Tissue
Authors: David Sergio Adriani , Valentim Carlos Alberto , Debbouche Amar
Published: March 2022

We investigate a class of fractional time-partial differential equations describing the dynamics of the fast action potential process in contractile myocytes. The system is explored in both one and two dimensional cases. Homogeneous and nonhomogeneous solutions are derived. We also numerically simulate some of the proposed fractional solutions to provide a different modeling perspective on distinct phases of cardiac membrane potential. Results indicate that the fractional diffusion-wave equation may be employed to model membrane potential dynamics with the fractional order working as an extra asset to modulate electricity conduction, particularly for lower fractional order values.
Nanotechnology in Cosmetics and Cosmeceuticals—A Review of Latest Advancements
Authors: Gupta Vaibhav , Mohapatra Sradhanjali , Mishra Harshita , Farooq Uzma , Kumar Keshav , Ansari Mohammad , Aldawsari Mohammed , Alalaiwe Ahmed , Mirza Mohd , Iqbal Zeenat
Published: March 2022

Nanotechnology has the potential to generate advancements and innovations in formulations and delivery systems. This fast-developing technology has been widely exploited for diagnostic and therapeutic purposes. Today, cosmetic formulations incorporating nanotechnology are a relatively new yet very promising and highly researched area. The application of nanotechnology in cosmetics has been shown to overcome the drawbacks associated with traditional cosmetics and also to add more useful features to a formulation. Nanocosmetics and nanocosmeceuticals have been extensively explored for skin, hair, nails, lips, and teeth, and the inclusion of nanomaterials has been found to improve product efficacy and consumer satisfaction. This is leading to the replacement of many traditional cosmeceuticals with nanocosmeceuticals. However, nanotoxicological studies on nanocosmeceuticals have raised concerns in terms of health hazards due to their potential skin penetration, resulting in toxic effects. This review summarizes various nanotechnology-based approaches being utilized in the delivery of cosmetics as well as cosmeceutical products, along with relevant patents. It outlines their benefits, as well as potential health and environmental risks. Further, it highlights the regulatory status of cosmeceuticals and analyzes the different regulatory guidelines in India, Europe, and the USA and discusses the different guidelines and recommendations issued by various regulatory authorities. Finally, this article seeks to provide an overview of nanocosmetics and nanocosmeceuticals and their applications in cosmetic industries, which may help consumers and regulators to gain awareness about the benefits as well as the toxicity related to the continuous and long-term uses of these products, thus encouraging their judicious use.
Novel Hydrogels for Topical Applications: An Updated Comprehensive Review Based on Source
Authors: Almoshari Yosif
Published: March 2022

Active pharmaceutical ingredients (API) or drugs are normally not delivered as pure chemical substances (for the prevention or the treatment of any diseases). APIs are still generally administered in prepared formulations, also known as dosage forms. Topical administration is widely used to deliver therapeutic agents locally because it is convenient and cost-effective. Since earlier civilizations, several types of topical semi-solid dosage forms have been commonly used in healthcare society to treat various skin diseases. A topical drug delivery system is designed primarily to treat local diseases by applying therapeutic agents to surface level parts of the body such as the skin, eyes, nose, and vaginal cavity. Nowadays, novel semi-solids can be used safely in pediatrics, geriatrics, and pregnant women without the possibility of causing any allergy reactions. The novel hydrogels are being used in a wide range of applications. At first, numerous hydrogel research studies were carried out by simply adding various APIs in pure form or dissolved in various solvents to the prepared hydrogel base. However, numerous research articles on novel hydrogels have been published in the last five to ten years. It is expected that novel hydrogels will be capable of controlling the APIs release pattern. Novel hydrogels are made up of novel formulations such as nanoparticles, nanoemulsions, microemulsions, liposomes, self-nano emulsifying drug delivery systems, cubosomes, and so on. This review focus on some novel formulations incorporated in the hydrogel prepared with natural and synthetic polymers.
Genome-Wide Association Study of Salt Tolerance at the Seed Germination Stage in Flax (Linum usitatissimum L.)
Authors: Li Xiao , Guo Dongliang , Xue Min , Li Gongze , Yan Qingcheng , Jiang Haixia , Liu Huiqing , Chen Jiaxun , Gao Yanfang , Duan Lepeng , Xie Liqiong
Published: March 2022

Soil salinization seriously affects the growth and distribution of flax. However, there is little information about the salt tolerance of flax. In this study, the salt tolerance of 200 diverse flax accessions during the germination stage was evaluated, and then the Genome-wide Association Study (GWAS) was carried out based on the relative germination rate (RGR), relative shoot length (RSL) and relative root length (RRL), whereby quantitative trait loci (QTLs) related to salt tolerance were identified. The results showed that oil flax had a better salt tolerance than fiber flax. A total of 902 single nucleotide polymorphisms (SNPs) were identified on 15 chromosomes. These SNPs were integrated into 64 QTLs, explaining 14.48 to 29.38% (R2) of the phenotypic variation. In addition, 268 candidate genes were screened by combining previous transcriptome data and homologous gene annotation. Among them, Lus10033213 is a single-point SNP repeat mapping gene, which encodes a Glutathione S-transferase (GST). This study is the first to use GWAS to excavate genes related to salt tolerance during the germination stage of flax. The results of this study provide important information for studying the genetic mechanism of salt tolerance of flax, and also provide the possibility to improve the salt tolerance of flax.
Role of Wheat Phosphorus Starvation Tolerance 1 Genes in Phosphorus Acquisition and Root Architecture
Authors: Abbas Hina , Naeem Muhammad Kashif , Rubab Marya , Widemann Emilie , Uzair Muhammad , Zahra Nageen , Saleem Bilal , Rahim Amna Abdul , Inam Safeena , Imran Muhammad , Hafeez Farhan , Khan Muhammad Ramzan , Shafiq Sarfraz
Published: March 2022

The wheat plant requires elevated phosphorus levels for its normal growth and yield, but continuously depleting non-renewable phosphorus reserves in the soil is one of the biggest challenges in agricultural production worldwide. The Phosphorus Starvation Tolerance 1 (PSTOL1) gene has been reported to play a key role in efficient P uptake, deeper rooting, and high yield in rice. However, the function of the PSTOL1 gene in wheat is still unclear. In this study, a total of 22 PSTOL1 orthologs were identified in the wheat genome, and found that wheat PSTOL1 orthologs are unevenly distributed on chromosomes, and these genes were under strong purifying selection. Under different phosphorus regimes, wheat PSTOL1 genes showed differential expression patterns in different tissues. These results strengthen the classification of Pakistan-13 as a P-efficient cultivar and Shafaq-06 as a P-inefficient cultivar. Phenotypic characterization demonstrated that Pakistan-13 wheat cultivar has significantly increased P uptake, root length, root volume, and root surface area compared to Shafaq-06. Some wheat PSTOL1 orthologs are co-localized with phosphorus starvation’s related quantitative trait loci (QTLs), suggesting their potential role in phosphorus use efficiency. Altogether, these results highlight the role of the wheat PSTOL1 genes in wheat P uptake, root architecture, and efficient plant growth. This comprehensive study will be helpful for devising sustainable strategies for wheat crop production and adaptation to phosphorus insufficiency.
The Artificial Intelligence in Digital Radiology: Part 1: The Challenges, Acceptance and Consensus
Authors: Giansanti Daniele , Di Basilio Francesco
Published: March 2022

Artificial intelligence is having important developments in the world of digital radiology also thanks to the boost given to the research sector by the COVID-19 pandemic. In the last two years, there was an important development of studies focused on both challenges and acceptance and consensus in the field of Artificial Intelligence. The challenges and acceptance and consensus are two strategic aspects in the development and integration of technologies in the health domain. The study conducted two narrative reviews by means of two parallel points of view to take stock both on the ongoing challenges and on initiatives conducted to face the acceptance and consensus in this area. The methodology of the review was based on: (I) search of PubMed and Scopus and (II) an eligibility assessment, using parameters with 5 levels of score. The results have: (a) highlighted and categorized the important challenges in place. (b) Illustrated the different types of studies conducted through original questionnaires. The study suggests for future research based on questionnaires a better calibration and inclusion of the challenges in place together with validation and administration paths at an international level.
A Systematic Review on Amaranthus-Related Research
Authors: Jimoh Muhali Olaide , Okaiyeto Kunle , Oguntibeju Oluwafemi Omoniyi , Laubscher Charles Petrus
Published: March 2022

Leafy vegetables promote reparation of energy loss due to oxidative stress, and they have the potential to alleviate hunger and malnutrition as well as other forms of metabolic imbalance ravaging the world. However, these vegetables are underutilized, despite the fact that they harbor essential minerals needed for critical cellular activities. As amaranth is one of the earliest vegetables reputed for its high nutraceutical and therapeutic value, in this study, we explored research on the Amaranthus species, and identified areas with knowledge gaps, to harness the various biological and economic potentials of the species. Relevant published documents on the plant were retrieved from the Science Citation Index Expanded accessed through the Web of Science from 2011 to 2020; while RStudio and VOSviewer were used for data analysis and visualization, respectively. Publications over the past decade (dominated by researchers from the USA, India, and China, with a collaboration index of 3.22) showed that Amaranthus research experienced steady growth. Findings from the study revealed the importance of the research and knowledge gaps in the underutilization of the vegetable. This could be helpful in identifying prominent researchers who can be supported by government funds, to address the malnutrition problem in developing countries throughout the world.
Contact Toxicity and Ovideterrent Activity of Three Essential Oil-Based Nano-Emulsions against the Olive Fruit Fly Bactrocera oleae
Authors: Giunti Giulia , Laudani Francesca , Lo Presti Emilio , Bacchi Monica , Palmeri Vincenzo , Campolo Orlando
Published: March 2022

The control strategies for the olive crop key pest, Bactrocera oleae, involve synthetic chemical insecticides and few eco-sustainable alternatives, such as ovideterrents and lures. In the last few decades, the interest concerning the formulation of botanical based biopesticides increased, but little research investigated the suitability of these approaches for B. oleae control. This research aimed to investigate the residual contact toxicity and the oviposition deterrence of three essential oil (EO)-based nano-emulsions (Pimpinella anisum, Foeniculum vulgare, Mentha × piperita) against B. oleae adult flies. All the nano-emulsions possessed optimal physical characteristics, with droplets dimensions ranging from 115 to 152 nm and low PDI values (<0.2), even after 1 year of storage. Although no notable residual contact toxicity was noted, all the tested formulations reduced the number of oviposition puncture in no-choice tests (percent repellence: mint < fennel < anise). In choice trials, olives treated with fennel and anise EO-formulations at the highest concentration (7.5%, 75 g of EO/L) were less attractive respect to control fruits and a significant reduction of olive punctures was recorded. Nano-biopesticides are promising eco-friendly tools to integrate B. oleae pest management programs and to reduce the use of harmful conventional active ingredients.
Interactions of Gibberellins with Phytohormones and Their Role in Stress Responses
Authors: Castro-Camba Ricardo , Sánchez Conchi , Vidal Nieves , Vielba Jesús
Published: March 2022

Gibberellins are amongst the main plant growth regulators. Discovered over a century ago, the interest in gibberellins research is growing due to their current and potential applications in crop production and their role in the responses to environmental stresses. In the present review, the current knowledge on gibberellins’ homeostasis and modes of action is outlined. Besides this, the complex interrelations between gibberellins and other plant growth regulators are also described, providing an intricate network of interactions that ultimately drives towards precise and specific gene expression. Thus, genes and proteins identified as being involved in gibberellin responses in model and non-model species are highlighted. Furthermore, the molecular mechanisms governing the gibberellins’ relation to stress responses are also depicted. This review aims to provide a comprehensive picture of the state-of-the-art of the current perceptions of the interactions of gibberellins with other phytohormones, and their responses to plant stresses, thus allowing for the identification of the specific mechanisms involved. This knowledge will help us to improve our understanding of gibberellins’ biology, and might help increase the biotechnological toolbox needed to refine plant resilience, particularly under a climate change scenario.
The Role of Recreation Specialization and Self-Efficacy on Life Satisfaction: The Mediating Effect of Flow Experience
Authors: Tian Haibo , Zhou Wenting , Qiu Yajun , Zou Zheng
Published: March 2022

Previous studies confirmed that leisure sport participation could contribute to people’s life satisfaction. However, little is known about the predictors of life satisfaction in the context of long-distance running. A model was proposed in this study to examine the relationship between recreation specialization, self-efficacy, flow experience, and life satisfaction. An online questionnaire was distributed to long-distance runners in China, and a total of 404 valid questionnaires were obtained for data analysis in this study. Results indicated that recreation specialization and self-efficacy had a direct and positive effect on runners’ flow experience; recreation specialization, self-efficacy, and flow experience were positively associated with runners’ life satisfaction. Furthermore, flow experience partially mediated the relationship between self-efficacy and life satisfaction, while it fully mediated the role of recreation specialization in life satisfaction. The findings shed some new insights for understanding the influence of leisure sport engagement on people’s life satisfaction.
UV-C Light-Based Surface Disinfection: Analysis of Its Virucidal Efficacy Using a Bacteriophage Model
Authors: Rudhart Stefan A. , Günther Frank , Dapper Laura , Stuck Boris A. , Hoch Stephan
Published: March 2022

Background: The reprocessing of medical devices has become more complex due to increasing hygiene requirements. Previous studies showed satisfactory bactericidal disinfection effects of UV-C light in rigid and flexible endoscopes. Especially in the context of the current COVID-19 pandemic, virucidal properties are of high importance. In the present study, the virucidal efficacy of UV-C light surface disinfection was analyzed. Methods: MS-2 bacteriophages were applied to the test samples and irradiated by UV-C light using the UV Smart D25 device; unirradiated test samples were used as controls. A dilution series of the samples was mixed with 1 × 108 Escherichia coli and assayed. Results: 8.6 × 1012 pfu could be harvested from the unprocessed test samples. In the control group without UV-C exposure, a remaining contamination of 1.2 × 1012 pfu was detected, resulting in a procedural baseline reduction rate with a LOG10 reduction factor of 0.72. The LOG10 reduction factor was found to be 3.0 after 25 s of UV-C light exposure. After 50 and 75 s of UV-C radiation LOG10 reduction factors 4.2 and 5.9, respectively, were found, with all reductions being statistically significantly different to baseline. Conclusions: The tested UV system seems to provide a significant virucidal effect after a relatively short irradiation time.
Who Tends to Appreciate Atonal Music? Higher Perceived Personal Control Leads to an Increased Inclination to Prefer Atonal Music
Authors: Liu Junfeng , Yang Shen-Long , Yu Feng
Published: March 2022

Research on the aesthetic experience of music has largely focused on tonal music, while relatively less is known about individuals’ differences in the aesthetic experience of atonal music. According to the compensatory control theory, we hypothesized that perceived personal control significantly and positively predicted individuals’ tendency to prefer atonal music, while the need for structure played a mediating role. The present research investigated who tends to prefer atonal music, and why. A sample of college students listened to atonal music and completed questionnaires on perceived personal control, the need for structure, and their aesthetic judgment of the music. Our analysis showed that individuals with higher perceived personal control exhibited a stronger tendency to prefer atonal music, compared with those who had lower perceived control; moreover, the need for structure played a mediating role between perceived control and aesthetic experience of atonal music. These results revealed which audience was suitable for atonal music and extended the explanatory scope of the compensatory control theory. The theoretical and practical implications and limitations of these findings are discussed.
Does Venue of HIV Testing and Results Disclosure in the Context of a Research Study Affect Adolescent Health and Behavior? Results from a Study in Western Kenya
Authors: Luseno Winnie Kavulani , Field Samuel H. , Iritani Bonita J. , Odongo Fredrick S. , Kwaro Daniel , Rennie Stuart
Published: March 2022

Ethical concerns about risks to minor adolescents participating in HIV prevention research is a barrier to their inclusion. One concern is whether HIV testing and results disclosure venue affects the health and behavior of adolescent participants. We assessed for differential effects on quality of life (QOL), depressive symptoms, and sexual behavior due to (1) testing venue (home or health facility) and (2) test result (HIV-positive, HIV-negative, indeterminate). We collected data at three timepoints (baseline, 2-month follow-up, 12-month follow-up) from 113 Kenyan adolescents aged 15–19 (51% female). We analyzed the data using linear mixed effects models for the QOL and depressive symptoms outcomes and a logistic model for the sexual behavior outcome. Results showed a small mental health benefit for adolescents tested for HIV at a health facility compared with home. There was little evidence that testing venue influenced sexual behavior or that test results moderated the effects of HIV testing across all outcomes. The decision to conduct HIV testing at home or a health facility may not be very consequential for adolescents’ health and behavior. Findings underscore the need to critically examine assumptions about adolescent vulnerability to better promote responsible conduct of HIV prevention research with youth in sub-Saharan Africa.
Health Benefits of the Diverse Volatile Oils in Native Plants of Ancient Ironwood-Giant Cactus Forests of the Sonoran Desert: An Adaptation to Climate Change?
Authors: Nabhan Gary Paul , Daugherty Eric , Hartung Tammi
Published: March 2022

We document the species richness and volatile oil diversity in Sonoran Desert plants found in the Arizona Uplands subdivision of this binational USA/Mexico region. Using floristics, we determined that more than 60 species of 178 native plants in the ancient ironwood-giant cactus forests emit fragrant biogenic volatile organic compounds (BVOCs), especially with the onset of summer monsoons. From these desert species, more than 115 volatile oils have been identified from one biogeographic region. For the 5 BVOCs most commonly associated with “forest bathing” practices in Asian temperate forests, at least 15 Sonoran Desert plant species emit them in Arizona Uplands vegetation. We document the potential health benefits attributed to each of 13 BVOCs in isolation, but we also hypothesize that the entire “suite” of BVOCs emitted from a diversity of desert plants during the monsoons may function synergistically to generate additional health benefits. Regular exposure to these BVOC health benefits may become more important to prevent or mitigate diseases of oxidative stress and other climate maladies in a hotter, drier world.
The Impact of the COVID-19 Pandemic on Mental Health Care of Children and Adolescents in Switzerland: Results of a Survey among Mental Health Care Professionals after One Year of COVID-19
Authors: Werling Anna Maria , Walitza Susanne , Eliez Stephan , Drechsler Renate
Published: March 2022

Background: To assess the impact of the COVID-19 pandemic on treatment demand and supply in children and adolescents with mental disorders during the first year of the pandemic from the perspective of child and adolescent psychiatrists and psychologists in Switzerland. Methods: The survey was conducted anonymously, in German or French and online in April/May 2021. Mental health professionals working in child and adolescent psychiatry, psychotherapy services or independent practices were contacted by email. Results: N = 454 professionals completed the survey (176 child and adolescent psychiatrists and 276 psychologists). After an initial period of decreased demand during the lockdown in spring 2020, requests for treatment increased, considerably exceeding the demand pre-pandemic and reaching a peak in January/February/March 2021. The vast majority of professionals (78.2%) estimated that there was currently too little supply during the pandemic, which differed from the evaluation of the pre-pandemic situation (37%). A total of 65% of participants indicated that waiting time until the initiation of treatment increased during the pandemic, 41% reported their current workload to be somewhat higher and 44.5% much higher. Conclusions: For the first pandemic year, youth mental health professionals reported a large increase in the treatment demand and waiting time and a worrisome overload of treatment services.
A Study of the MTHFR Gene Prevalence in a Rural Tennessee Opioid Use Disorder Treatment Center Population
Authors: Cole Leslie , Cernasev Alina , Webb Katie , Kumar Santosh , Rowe A. Shaun
Published: March 2022

Background: Opioid Use Disorder (OUD) has been linked to dopamine and the neurological reward centers. Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in the production of many neurotransmitters such as dopamine. As such, MTHFR variants that lead to decreased production of neurotransmitters may play a role in OUD. However, lacunae exist for characterizing the prevalence of the MTHFR mutations in an OUD population. The objective of this study was to determine prevalence of the MTHFR gene mutations in a rural Tennessean population with OUD. Methods: This study was a retrospective cohort of individuals with OUD that evaluated the prevalence of MTHFR variants. Patients were categorized as normal, homozygous C677T, heterozygous C677T, homozygous A1298C, or heterozygous A1298C. The primary outcome was a qualitative comparison of the prevalence of each of the MTHFR variants in our cohort to the publicly reported MTHR polymorphism prevalence. Secondary outcomes include race and ethnicity differences as well as stimulant use differences for each of the variants. Results: A total of 232 patients undergoing care for opioid use disorder were included in the study. Of those included, 30 patients had a normal MTHFR allele and 202 had a variant MTHFR allele. Overall, the prevalence of any MTHFR variant was 87.1% (95% CI 82.6–91.4%). When comparing those with a normal MTHFR allele to those with any MTHFR variant, there was no difference in age, sex, race and ethnicity, or stimulant use. Conclusion: The overall prevalence of MTHFR variants in patients with opioid use disorders is high.
Characterization of Scale Deposits in a Drinking Water Network in a Semi-Arid Region
Authors: Padilla González Pedro , Bautista-Capetillo Carlos , Ruiz-Canales Antonio , González-Trinidad Julián , Júnez-Ferreira Hugo Enrique , Contreras Rodríguez Ada Rebeca , Robles Rovelo Cruz Octavio
Published: March 2022

The quantity and quality of the supply of fresh water to households, commercial areas, small industries, green spaces irrigation and public and private institutions in large cities face challenges from the supply sources availability and suitable distribution network performance to the full satisfaction of the established drinking water guidelines. In Mexico, the main source of water comes from groundwater. Most of the Mexican aquifers are located in arid and semi-arid weather conditions. The groundwater’s physical–chemical properties are closely related to geology. This study was carried out at the north-central part of the country in which igneous and sedimentary rocks predominate, with high calcium carbonate (CaCO3) concentrations. The accumulation of CaCO3 in the pipelines is also known as scale deposit that decreases the fluid flow, causing a deficiency in the water supply. The main objectives of this study were determining the physical–chemical groundwater parameters and saturation indexes injected into the drinking water networks and characterizing the scale deposits by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The results indicate that the scale deposits are mainly calcium carbonate and silica oxide crystals, caused by the water aggressiveness according to the saturation indexes and the lack of control over the saturation pH.
Community Participation and Subjective Well-Being of Older Adults: The Roles of Sense of Community and Neuroticism
Authors: Chen Lanshuang , Zhang Zhen
Published: March 2022

Participation in community affairs and activities is beneficial to the mental health of older adults. The current study attempted to confirm the mediating role of sense of community (SoC) between community participation (CP) and subjective well-being (SWB), and the moderating role of neuroticism between CP and SoC. A total of 465 older adults aged ≥65 years from China participated in both two-wave online surveys. The self-developed Community Participation questionnaire, the SoC scale, and the Neuroticism subscale were used to assess CP, SoC, and neuroticism, respectively. The four indicators of SWB were assessed by the Satisfaction with Life Scale, Positive Affect and Negative Affect Schedule, and the Center for Epidemiological Studies-Depression scale. The results revealed that CP was associated with three indicators of SWB including life satisfaction, positive affect, and depressive symptoms, SoC mediated the above associations, and neuroticism negatively moderated the association between CP and SoC, after controlling for age, sex, education, spouse status, monthly income, and physical health. CP enhances older adults’ SWB through increasing their SoC. When compared to those older adults with a higher score of neuroticism, the enhancing effect of CP on SoC is stronger for those with lower scores of neuroticism.
Association between Lower-Body Strength, Health-Related Quality of Life, Depression Status and BMI in the Elderly Women with Depression
Authors: Galán-Arroyo Carmen , Pereira-Payo Damián , Denche-Zamorano Ángel , Hernández-Mocholí Miguel A. , Merellano-Navarro Eugenio , Pérez-Gómez Jorge , Rojo-Ramos Jorge , Adsuar José Carmelo
Published: March 2022

Introduction: Depression is currently the most prevalent mental illness in the world. It is a very frequent geriatric syndrome that causes a high degree of disability and increases mortality in the elderly population. This mental disorder is a social and public health problem that alters the quality of life (Qol) of the patient. Physical strength work has been reported to improve the clinical picture of people with depression. Objective. To determine the relationship between lower body strength, health-related quality of life (HRQoL), depression status and body mass index (BMI) in older women with depression. Design: A cross-sectional descriptive study with 685 elder women with depression. Results: A mild direct correlation (Rho = −0.29; p ≤ 0.001) between stand-ip test and EQ-5D-3L test was shown. There is a mild inverse correlation between stand-up test and six of fifteen items of the Geriatric Depression Scale (GDS) (Rho item 1 = −0.24; p ≤ 0.001; item 4 = 0.11; p ≤ 0.001; item 5 = −0.20; p ≤ 0.001; item 7 = −0.15; p ≤ 0.001; item 11 = −0.19; p ≤ 0.001; item 13 = −0.21; p ≤ 0.001). Between Stand-Up test and BMI, the correlation is weak inverse (Rho = −0.20; p ≤ 0.001). Conclusions: There is a significant association of lower body strength with HRQoL, and BMI, as well as some variables of depression status in elder women with depression. Better scores in the stand-up test lead to an improvement in HRQoL and BMI. Therefore, stand-up test could be a complementary tool in public health for improve HRQoL in the elderly women with depression.
Political Populism, Institutional Distrust and Vaccination Uptake: A Mediation Analysis
Authors: Recio-Román Almudena , Recio-Menéndez Manuel , Román-González María Victoria
Published: March 2022

Politics is ubiquitous in public health, but vaccines had never been weaponized to instill distrust to gain political advantage. In pandemic and post-pandemic scenarios, populist political parties could use vaccine-related issues to generate distrust in evidence-based knowledge. Therefore, some questions arise. What impact could populist political parties impinge on vaccination uptake rates through sowing political discontent? What could the medical institutions do to avoid the adverse effects that these political strategies could infringe? For answering these research questions, we first hypothesized that vaccine uptake was negatively associated with distrust in the institutions. Furthermore, we analyzed whether populism mediates this relationship. In doing so, we hypothesized a positive association between distrust and populism, because populists, mainly fueled by politically discontent citizens, offer hope of a better future, blaming their misfortune on the actions of the elite. Additionally, we hypothesized that those citizens with a higher level of political dissatisfaction, following the claims of the populist political parties, will have lower vaccine uptake results, because they will be discouraged from making the efforts to counter the pandemic. Based on a survey carried out by the European Commission that covered 27 E.U. + U.K. countries (totaling 27,524 respondents), this paper proves that an individual’s political discontent fully mediates the relationship between distrust in institutions and vaccine uptake. Targeting the vaccine-hesitant population is quite convenient for populists because they only need to convince a minority of citizens not to be vaccinated to achieve their destabilizing goals. New outbreaks will appear if the minimum herd immunity coverage is not reached, reinforcing a vicious circle of distrust in elites, in consequence. For tackling this matter, recommendations are given to institutional managers from a social marketing standpoint.
Advancing Liver Cancer Prevention for American Indian Populations in Arizona: An Integrative Review
Authors: Godfrey Timian M. , Villavicencio Edgar A. , Barra Kimberly , Sanderson Priscilla R. , Shea Kimberly , Sun Xiaoxiao , Garcia David O.
Published: March 2022

Liver cancer is a highly fatal condition disproportionately impacting American Indian populations. A thorough understanding of the existing literature is needed to inform region-specific liver cancer prevention efforts for American Indian people. This integrative review explores extant literature relevant to liver cancer in American Indian populations in Arizona and identifies factors of structural inequality affecting these groups. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines informed the methodology, and a literature search was conducted in PubMed, EMBASE, CINAHL, and PsycInfo for articles including Arizona American Indian adults and liver disease outcomes. Seven articles met the inclusion criteria in the final review. Five of the studies used an observational study design with secondary analysis. One article used a quasiexperimental approach, and another employed a community-engagement method resulting in policy change. The results revealed a lack of empirical evidence on liver cancer prevention, treatment, and health interventions for American Indian populations in Arizona. Research is needed to evaluate the high rates of liver disease and cancer to inform culturally relevant interventions for liver cancer prevention. Community-engaged research that addresses structural inequality is a promising approach to improve inequities in liver cancer for American Indian people.
Liver Disease Screening and Hepatitis C Virus Elimination in Taiwan Rural Indigenous Townships: Village-By-Village Screening and Linking to Outreach Hepatology Care
Authors: Tien Hui-Min , Cheng Tai-Chung , Lien Hsiao-Chu , Yang Kuei-Fei , Shy Cherng-Gueih , Chen Yu-Ling , Hsu Nien-Tzu , Lu Sheng-Nan , Wang Jing-Houng
Published: March 2022

Medical resources are limited for hepatitis C virus (HCV) elimination in rural indigenous areas of Taiwan. This study aimed to investigate liver disease risk and conduct a HCV elimination program in two rural indigenous townships. A program of village-by-village screening tests was conducted including hepatitis B virus surface antigen (HBsAg), antibody to HCV (anti-HCV) and gamma-glutamyl transferase (GGT), linking to outreach hepatology care at two indigenous townships (Laiyi and Mudan). Adult residents were invited to join this program. One hepatology specialist assessed liver disease risk, provided HCV treatment counselling and initiated direct acting antivirals (DAA) at an outreach hepatology clinic in primary health centers. A total of 3503 residents attended this program with a screening coverage of 73.5%. The prevalence of HBsAg, anti-HCV, and high GGT level was 8.2%, 10.0% and 19.5%, respectively. Laiyi had significantly higher prevalence of anti-HCV than Mudan. While males had significantly higher prevalence of HBsAg and high GGT in both townships, females in Laiyi had higher anti-HCV prevalence. HBsAg and high GGT prevalence peaked at 40–59 years of age and anti-HCV prevalence increased significantly with age. Two hundred and sixty-three residents visited the outreach hepatology clinic for HCV treatment evaluation, with 121 (46%) residents having active HCV, while 116 received DAA, with 111 (95.7%) achieving HCV elimination. For rural indigenous townships in southern Taiwan, HCV infection and alcohol consumption were two major liver disease risks. While HCV infection was predominant in old females, chronic hepatitis B virus infection and habitual alcohol consumptions predominated in middle-aged males. HCV elimination was achieved by the village-by-village screening model and linked to outreach hepatology care.
Sleep Disturbances, Degree of Disability and the Quality of Life in Multiple Sclerosis Patients
Authors: Kołtuniuk Aleksandra , Kazimierska-Zając Magdalena , Pogłódek Dominika , Chojdak-Łukasiewicz Justyna
Published: March 2022

Sleep disturbances are pervasive in patients with multiple sclerosis (MS), with incidence about four times higher compared to the general population. The most frequent primary sleep problems include insomnia, restless leg syndrome, sleep-related movement disorders, and sleep-disordered breathing. This study aims to assess the relationships between sleeping problems and the quality of life (QoL) in MS patients. This cross-sectional study was conducted among 152 MS patients (mean age: 36.27 ± 9.60) between November 2018 and February 2019 at a neurological health center in Wroclaw, Poland. The study was based on a questionnaire that included questions concerning sociodemographic and clinical data in addition to the following standardized questionnaires: Athens Insomnia Scale (AIS), Epworth Sleepiness Scale (ESS), and Multiple Sclerosis International Quality of Life (MusiQoL). The degree of physical disability was evaluated following the Expanded Disability Status Scale (EDSS). Analysis of the research material showed that 66.45% of MS patients had insomnia, and 41.45% presented with daytime sleepiness. The QoL of respondents was assessed as average (50.73). Univariate linear regression model analysis showed the effects of professional status, daytime sleepiness, insomnia, and degree of disability on the QoL of MS patients. Sleep disturbances are widespread in MS patients. The presence of sleep disturbances (insomnia and daytime sleepiness) significantly affects the QoL of MS patients.