bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of SNP in the CDH8 and CDH10 Genes Associated with Autism Using In-Silico Tools
Authors: Rezaeirad Azadeh , Karasakal Ömer Faruk , Kaman Tuğba , Karahan Mesut
Published: March 2024

Autism spectrum disorder (ASD) is defined as a pervasive and multifactorial neurodevelopmental disorder (ND). It is characterized by repetitive behavioral patterns as well as symptoms of social interaction and communication disorder. The cadherin (CDH) superfamily is a large group of synaptic cell adhesion molecules and has been widely related with ND, including autism. The aim of this study is to evaluate the potentially deleterious missense single nucleotide polymorphisms (SNPs) in CDH8 and CDH10 genes, which are related with ASD and cause amino acid changes, using internet-based software tools. To identify potentially harmful missense SNPs; all SNPs were screened using SIFT, PolyPhen-2, PROVEAN, SNPs&GO, Meta-SNP, and SNAP2 software tools, and common deleterious ones were filtered out. Its effect on protein stabilization was investigated with I-Mutant 3.0 and MUpro tools. Three-dimensional models of these common damaging amino acid changes were evaluated with the HOPE software. As a result of in silico analysis of 577 missense SNPs in the CDH8 gene; The rs145143780 (Y572C) polymorphism common damaging ‎SNP has been detected by all software tools.‎ According to the results of the in silico analysis of 526 missense SNPs found in the CDH10 gene; The rs13174039 (V459G), rs147882578 (N485K), rs201423740 (Y306C), rs201956238 (F317L) and rs373340564 (R128C) common damaging SNPs have been identified in all polymorphisms by all software tools. As a result of this study, it is thought that the data obtained will make important contributions to future relevant experimental studies.
Molecular Dynamics Simulation of Bauschinger Effect in Cu Nanowire with Different Crystallographic Orientation
Authors: Kazanç Sefa , Aksu Canbay Canan
Published: March 2024

In this study, the Bauschringer Effect (BE) resulting from tension-compression deformation applied to nanowires obtained by placing Cu atoms in , and highly symmetric crystallographic directions was investigated using the Molecular Dynamics (MD) simulation method. The forces between atoms were determined from the gradient of the Embedded Atom Method (EAM) potential function, which includes many-body interactions. It was determined that there is an asymmetry between the stress-strain curves obtained as a result of the tension and compression deformation process applied to the model system. From this asymmetry, it was determined that the yield stress obtained in the drawing process for nanowire with crystallographic orientation was greater than the yield strain obtained as a result of the compression process. In contrast, the opposite was found for nanowires with crystallographic orientation and . In addition, after the yield strain value is exceeded as a result of the drawing process applied to the model nanowire system, compression deformation process was applied at different pre-strain values. The existence of the Bauschinger Effect (BE), which is expressed as the yield strength value as a result of forward loading corresponding to the tension operation, is smaller than the yield value obtained as a result of the compression process in which the loading is removed, was determined. To clarify the effect of BE on Cu nanowires with different crystallographic orientations, Bauschinger Stress parameter (BSP) and Bauschinger Parameter (BP) values were calculated.
Hubungan Motivasi Belajar Dengan Prestasi Belajar Siswa
Authors: Markus Arkian Terong  , Matilda Pia Bone  , Rosa Mustika Bulor
Published: March 2024

The focus of this research is to see whether there is a relationship between learning motivation and learning achievement students. This study aimed to investigate the significant relationship between learning motivation and learning achievement of eight grade students at SMP Negeri 16 Kupang in the academic year of 2023/2024. This study belonged to quantitative descriptive method. The variables of this study were independent variable (X) learning motivation and dependent variable (Y) learning achievement. The population was all students in class A of eight graders at SMP Negeri 16 Kupang in the academic year of 2023/2024. 23 students were chosen as the sample of this research. The data collection technique used in this study was a questionnaire. The product moment correlation was used as the data analysis technique in this study. The results of data analysis showed a value of Pearson Correlation was 0.575 with a significance value obtained of 0.00 <0.05, including the strong category. The finding showed that there was a significant relationship between learning motivation and the learning achievement in class A of eight graders at SMP Negeri 16 Kupang in the academic year of 2023/2024.
E-Learning is Effectively Used for Leadership Courses at Metamedia Universities
Authors: Maulana Ilham Tri , Muhammad Giatman  , Hasan Maksum
Published: March 2024

This development research aims to develop learning media (E-Learning) in all courses at Metamedia University. E-Learning is designed to improve student learning outcomes, so students can fully understand the material provided. This study uses the Instructional Development Institute development method. IDI procedures are defining, developing, and evaluating. The type of data is primary data where the data obtained from media experts, lecturers and students. Data were analysed using Descriptive Data Analysis Techniques which describe the validity, practicality, and effectiveness of using E-Learning. The results obtained from this research and development are as follows; (1) The validity of E-Learning is stated to be very valid in terms of content and interest with a total validity value of 84.54%, while the design aspect is stated to be valid with a total value of 85.55% (2) The practicality of E-Learning is based on the lecturer's response after through validation is stated to be quite practical with a total score of 76%, while the practicality of E-learning based on student responses after going through validation is stated to be practical with a total score of 84.12% (3) The effectiveness of E-Learning is effective in improving student learning outcomes as indicated by the number of students who has passed the Minimum Completeness Criteria (87.42%). Based on the findings of this study, it was concluded that E-Learning is valid, practical and effective for use as a learning medium
Exportações Sergipanas: uma análise comparativa dos exercícios 2020 e 2021
Authors: Câmara Jéssica Maria Damião de Arruda , Cunha Quéfira Kerollyn Inácio dos Santos , Soares Adeliane Marques , Brito Arthur Arcelino de , Sena João Eugênio da Silva , Lima Alessandro Jackson Teixeira de , Praxedes Dalilla de Medeiros , Santana Nathaly Silva de
Published: March 2024

Um dos assuntos relevantes quando se trata de logística internacional são as exportações, pois através delas movimentamos parte do comércio internacional, por meio delas aumentam-se as relações internacionais de um país ou estado. Este artigo tem como objetivo analisar os dados das exportações do estado de Sergipe fazendo um comparativo dos anos 2020 e 2021, analisando seus dados a fim de contribuir para futuras pesquisas em relação a este estado. Este trabalho é uma pesquisa quantitativa e exploratória, onde por meio do Ministério da Indústria, Comércio Exterior e Serviços foram obtidas informações sobre as exportações em Sergipe e analisados os dados dos anos de 2020 e 2021. Obtendo resultados de mudanças e variações do estado de Sergipe em relação às suas exportações.
Análise de performance do subsetor eletroeletrônico do polo industrial de Manaus
Authors: Harb Antonio Geraldo , De Paiva Francisco Canidé
Published: March 2024

O objetivo principal deste artigo foi descrever a atuação do subsetor eletrônico do Pólo Industrial de Manaus, no período de 2017 a 2019. Para tanto, foi realizada pesquisa bibliográfica e documental a fim de subsidiar o estudo quanto ao posicionamento estratégico deste segmento. e coleta de dados para posterior análise. Os resultados demonstraram uma dependência de insumos importados do mercado externo em detrimento daqueles oferecidos no mercado nacional. As importações excedem largamente as exportações, tornando este sector um modelo puramente importador. O maior mercado consumidor dos produtos fabricados nesse segmento é o mercado interno, responsável por cerca de 85% do seu faturamento. O estudo demonstrou que o subsetor eletroeletrônico constitui o maior pilar de sustentação do modelo da Zona Franca de Manaus.
Innovation of the customs value management process in imports between related parties
Authors: Gonçalves Ricardo Guimarães , Franklin Marcos Antonio
Published: March 2024

This technological article presented a solution that considers a procedure of monitoring and controling in the price, for a problem related to the Customs Valuation (CV) criterion in import operations between related parties, carried out by Siemens Energy (SE) Brasil Ltda, in order to structure an innovative control procedure in this customs criterion. The methodology used was the practical and applied work by Marcondes, Miguel, Franklin, and Perez (2017), in addition to qualitative research, with the use of the technique of interviews with Siemens Energy executives and a Brazilian Federal Revenue Office – RFB server. The proposed application of the solution deals with an incremental innovation in process, which considers a procedure focused on the governance and management of operational risks in the CV criterion in intercompany imports of SE. The complexity lies in the development of the solution proposal because it is a fully technical and decentralized issue.
Development and biochemical profile of Zingiber officinale under different population densities of Meloidogyne javanica
Authors: Santana-Gomes Simone de Melo , Silva Monique Thiara Rodrigues e , Barros Beatriz Cervejeira Bolanho , Souza Sandra Beserra da Silva de , Pinheiro Jadir Borges , Dias-Arieira Claudia Regina
Published: March 2024

Ginger is a medicinal plant known for its aromatic, antioxidant, and pharmacological properties. This study aimed to examine the vegetative growth and biochemical profile of ginger exposed to Meloidogyne javanica at different initial inoculum levels. The experiment was conducted in a greenhouse using a completely randomized design. Treatments comprised 0, 2000, 4000, 6000, 8000, and 10,000 eggs of M. javanica and eight replications per treatment. At 70 days after inoculation, plants were harvested and evaluated for nematode parameters, vegetative growth, total phenolic compounds, gingerol content, antioxidant activity, and soluble sugars content. Total nematode number increased linearly as a function of initial inoculum level. The reproduction factor was greater than one (RF>1) in all treatments. Vegetative development, however, was not affected. The highest concentrations of total phenolics and gingerol were estimated to occur with initial inoculum levels of 4500 and 4000 eggs, respectively. Higher population levels (>6000 eggs) stimulated the production of soluble sugars in ginger rhizomes. Although increasing levels of M. javanica did not affect ginger vegetative development, it significantly altered biochemical parameters, such as total phenolic compounds, gingerol content, antioxidant activity, and soluble sugars content, proving that M. javanica influences the quality of ginger.
Social Dynamics of Geographical Indications: Community Empowerment and Collective Identity
Authors: Yadav Abhishek
Published: March 2024

Geographically indicated products (GIs) are those that are specific to a given geographic environment and have a unique traditional knowledge that sets them apart from products that look similar. Both the producer and the consumer benefit from certification, as it increases the producer's ability to command a higher price for quality assurance.Because of its distinctiveness, GI promotes resource conservation in the affected community, which aids in the development of rural sustainable communities. From the perspective of the consumer, the protection of GIs gives assurance and specific information. GIs highlight significant features that may not be immediately apparent or evident from merely looking at the products. For instance, consumers may find it difficult to discern qualities that are merely visually appealing. This paper examines the relevance of geographical indications for the economy of a geographical area and then moves on to analyze the impact and correlation of GI and social identity and empowerment.
Removal of the central venous port system in children. Is this an appropriate training procedure for resident physicians? A single-center retrospective study
Authors: Sosnowska-Sienkiewicz Patrycja , Ciechanowicz Julia , Miedziarek Cezary , Bućko Ewa , Mańkowski Przemysław
Published: March 2024

Introduction: A venous port system consists of a port chamber attached to a central catheter, which is implanted into the central venous system. The removal of the vascular port includes all items of this system. This procedure is usually simple and quick. Complications with port removal are rare but possible.Aim: The study aimed to summarize venous port removal procedures performed by pediatric surgeons.Material and methods: The single-center, retrospective study was conducted on 360 pediatric patients treated during the years 2010–2022 in the Department of Pediatric Surgery, Traumatology, and Urology in Poznan.Results: The port usage time before the removal ranged from 3 days to 8 years and 3 months, with an average of 22 months. The leading cause of vascular port removal was the end of treatment (78.06%). Other less frequent reasons were the infection (13.89%) and mechanical damage of the port (3.33%). There were almost no complications connected with the procedure of vascular port removal (92.2%). If the complications occurred, they included bleeding during surgery (3%), covering the vascular catheter with bone tissue of the clavicle, causing difficulties with the catheter removal from the vein (1.4%), and connected with the previous complications-prolonged clavicle pain after surgery (1.4%) and hematoma after surgery (2%).Conclusions: Removing the venous port is a safe procedure with a low risk of complications. This procedure can be considered as an appropriate training procedure for young trainees. A more extended period of use of the vascular port before its removal may be associated with more difficulties during surgery.
THE ORGANIZATION OF DECONTAMINATION FOR PERSONAL PROTECTIVE EQUIPMENT USED IN INCIDENTS INVOLVING HAZARDOUS MATERIALS
Authors: Matuszkiewicz Rafał , Mizerski Andrzej , Polańczyk Andrzej
Published: March 2024

Contemporary civilization is invariably accompanied by disasters, industrial accidents, infectiousdiseases and increasingly frequent terrorist attacks. Despite the use of ever more sophisticatedsafeguards accompanying the development of civilization and modern branches of the economy,these phenomena will inevitably keep occurring. The possibility of sudden unforeseen incidentscaused by the impact of chemical, biological, or radiological factors requires constant readiness ofunits of the State Fire Service. The work analyses the decontamination process used in Germany,North America and Poland. This enabled the development of proposals for organizing thedecontamination process applied to personal protective equipment, constituting a combinationof selected solutions, which allows for the implementation of systemic changes in the State FireService.
Los factores de competitividad empresarial en los emprendimientos productivos artesanales de la ciudad de Portoviejo (Ecuador)
Authors: Delgado-Loor Ariana Yadira , Zambrano-Montesdeoca Jasson Luis
Published: March 2024

La artesanía en Portoviejo representa un legado cultural invaluable y una fuente de desarrollo económico local. Sin embargo, los emprendimientos artesanales enfrentan diversos desafíos para destacar en el mercado actual y alcanzar su máximo potencial. El presente trabajo tiene como objetivo determinar la incidencia de la competitividad en los emprendimientos productivos artesanales de la Ciudad de Portoviejo. Se presenta un análisis de los factores de competitividad empresarial en los emprendimientos productivos artesanales de la ciudad de Portoviejo, la metodología a seguir para analizar los factores de competitividad de este sector, se sustenta en métodos y técnicas científicas (observación, entrevistas y encuestas) aplicadas a los artesanos de la ciudad de Portoviejo, siendo esta investigación exploratoria, descriptiva y explicativa, donde se realizó una encuesta a artesanos y una entrevista realizada al director de la dirección de desarrollo económico y productivo del GAD municipal de cantón Portoviejo .

Los resultados obtenidos, presentan los principales factores de competitividad que la competitividad de los emprendimientos artesanales en Portoviejo se ve afectada por diversos desafíos, como la falta de acceso a mercados, el limitado acceso a financiamiento y la necesidad de capacitación. Sin embargo, también se identifican oportunidades para el crecimiento del sector, como el potencial del mercado artesanal, el apoyo gubernamental y el desarrollo del comercio electrónico.
IMPACTOS DE TECNOLOGIAS ASSISTIVAS NA REABILITAÇÃO DE PACIENTES: UMA REVISÃO INTEGRATIVA
Authors: Prado Maria Rosa Machado , Miranda Isabel Hahn , Quintana Laura Alchieri de la Cruz , Silveira Isabela Hodecker da , Corrêa Matheus
Published: March 2024

O advento das tecnologias assistivas na medicina tem se mostrado uma forma de potencializar processos em saúde, como a reabilitação de pacientes, apresentando resultados satisfatórios em termos de evolução clínica durante a reabilitação e promovendo o envolvimento do paciente no seu próprio processo saúde-doença e auxiliar na aquisição de conhecimento sobre o tratamento realizado. Esta revisão integrativa objetivou identificar e comparar os resultados obtidos na literatura sobre os impactos que as Tecnologias de Informação e Comunicação (TICs) têm no processo de reabilitação do paciente e suas formas de utilização. O levantamento bibliográfico foi realizado em bases de dados eletrônicas como PubMed, Biblioteca Virtual em Saúde e ScienceDirect. Foram encontrados 96 artigos, sendo que 12 artigos atenderam aos critérios de inclusão. Os resultados do estudo mostraram que o uso das TICs na reabilitação contribui para a adesão ao tratamento, melhora a qualidade de vida do paciente, aumenta a efetividade do processo de reabilitação e permite que os pacientes realizem exercícios em casa.
Redes sociales y su influencia con posicionamiento de marca de la empresa “vivero líder”-Manta
Authors: Vite Bailón Grace Vanessa , Moran Quiñonez Carlos Julio
Published: March 2024

Las redes sociales son importante para las Mipymes generando gran impacto entre sus clientes, al utilizar esta estrategia la empresa logra el posicionamiento de su marca, por lo que se obtiene buenos resultados, y se comprueba mediante las encuestas realizada a 214 clientes de la empresa, donde indican que, al permitirles interactuar constantemente en sus cuentas de redes sociales, logran su captación y fidelización, cumpliendo con el objetivo principal de la investigación demostrando que las redes sociales influyen en el posicionamiento de marca de la empresa “Vivero Líder”. La metodología es de tipo descriptivo, explicativo y bibliográfico, con un enfoque cuantitativo, se desarrollaron encuestas con 17 ítems, y se comprobó una fiabilidad de 0,946, aplicada en el software IBM SPSS-27. Lo cual confirma que las Redes Sociales son una estrategia que permite alcanzar los objetivos logrando favorablemente el posicionamiento de la marca de la empresa.
Palabras Clave: Redes sociales, Empresa, Estrategia, Servicio, Producto, Interactuar.
EXTRACELLULAR EXPRESSION OF THE ALPHA-AMYLASE GENE FROM BACILLUS AMYLOLIQUEFACIENS MDC1974 STRAIN USING BACILLUS SUBTILIS RIK1285 CELLS
Authors: Soghomonyan Tigran
Published: March 2024

The alpha-amylase gene from Bacillus amyloliquefaciens MDC1974 strain was molecularly cloned into the E. coli/B. subtilis pBE-S shuttle vector and subsequently expressed extracellularly by the recipient strain Bacillus subtilis RIK1285, which exhibited low protease activity. As a result of optimizing fermentation conditions, a secretion of alpha-amylase with an activity of 1400 units per mL was achieved.
SOURCES OF POLLUTION OF SURFACE WATERS, DEVELOPMENT OF RECOMMENDATIONS FOR THEIR DETECTION AND DEVELOPMENT OF PREVENTION METHODS
Authors: Darchidze Guram
Published: March 2024

The problem of water pollution is becoming more and more urgent for the whole world. Unfortunately, Georgia is not an exception, where water sources, despite their number, are small and a significant part of them is polluted.
Unlike contamination of industrial wastewater treatment plants, which comes from multiple diffuse sources, biological contamination results from the movement of precipitation or snowmelt onto and into the soil. As runoff moves, it collects and transports natural and anthropogenic pollutants and deposits them in rivers, groundwater, or lakes.
Special attention should be paid to the biological pollution of water sources, which occurs as a result of washing or flushing of sources of anthropogenic biological pollution with rain and melt water. After entering the water environment, under favorable conditions, pathogenic organisms can multiply rapidly, which poses a threat to the environment.
Contamination of water sources is a major cause of water quality problems. The impact of source water contaminants on specific waters varies and cannot always be fully assessed. However, we know that these pollutants have harmful effects on drinking water supplies and wildlife.
That is why it is necessary to find the source of biological pollution of water in order to develop an effective method of its elimination.
The Influence of Leadership and Organizational Culture Employee Performance at Medan Adventist Hospital
Authors: Pandiangan Gibson , Malau Harman , Siagian Harlyn
Published: March 2024

The aim of this investigation was to ascertain whether leadership and organizational culture impact employee performance at Medan Adventist Hospital. This study adopts a quantitative research design, aimed at discerning and demonstrating the influence of one variable on others. The study encompasses the entire workforce of Medan Adventist Hospital, totaling 372 individuals. Employing the Solovin-based sampling technique, a total of seventy-nine employees will be selected for interviews, ensuring proportional representation across sections. The research employs descriptive data analysis techniques alongside multiple regression analysis, incorporating T-tests (partial tests), F-tests (simultaneous tests), and determination coefficient tests (R2). The analysis tool utilized in this study is the multiple linear regression model. The findings of this research validate that individual leadership significantly impacts the performance of Medan Adventist Hospital employees, while individual organizational culture similarly exerts a notable influence. Simultaneous testing demonstrates that both leadership and organizational culture collectively affect the performance of employees at Medan Adventist Hospital.
Pengaruh Service Excellent Unit Ground Handling Kokapura Terhadap Kepuasan Penumpang di Bandar Udara Internasional Jendral Ahmad Yani Semarang
Authors: Iklima Pingky Afsherina  , Hodi
Published: March 2024

The main objectives of this research are as follows: 1) evaluate how much influence the excellent service of the Kokapura ground handling unit at Ahmad Yani International Airport Semarang has on passenger satisfaction; and 2) measure how much influence the excellent service of the Kokapura ground handling unit at Ahmad Yani International Airport Semarang has on passenger satisfaction. This research used a quantitative approach and collected 100 respondents who were passengers at Ahmad Yani International Airport, Semarang. The purposive sampling method was used for non-probability sampling. Certain criteria were used to select respondents. The results of statistical data analysis show that each statement in this study is valid and the variables are reliable. Hypothesis testing produces a significance value of 0.000 < 0.05 which indicates rejection of H0, and a calculated t value of 4.155 > t table value of 1.660 which indicates acceptance of Ha. The results of the regression test show that there is a positive and significant influence of 39.4%. In conclusion, the ground handling unit excellent service variable (X) has a significant influence on the passenger satisfaction variable (Y). In other words, this research proves that the excellent service of the Kokapura ground handling unit has a positive and significant effect on the level of passenger satisfaction at Ahmad Yani International Airport, Semarang. influence of 39.4%.
Pengaruh Customer Engagement, Perceived Quality, dan Perceived Value Terhadap Repurchase Intention pada Produk Mcdonald's
Authors: Mohamad Rafli Azhar  , Sophiyanto Wuryan
Published: March 2024

The current condition of society is that their lifestyles are becoming increasingly sophisticated, accompanied by their increasing consumption tastes, creating a situation where choosing products becomes more thorough and thorough. The main aim of this research is to determine the influence of Customer Engagement, Perceived Quality, and Perceived Value on Repurchase Intention. The sampling technique used in this research was purposive sampling with a nonprobability sampling method. The number of respondents used in this research was 90 respondents with the criteria being men and women aged minimum 18 years, and had purchased McDonald's products at least 2 times within a period of 1 month. The analytical method used is multiple linear regression. The results of this research prove that customer engagement, perceived quality and perceived value felt by users can increase repurchase intention for McDonald's products so that they can attract consumers minimum 18 years to repurchase intention for McDonald's products. Customer engagement, perceived quality and perceived value can increase repurchase intention for McDonald's products. This of course benefits businesses, especially fast food businesses and creates company success in the long term.
RHABDOMYOLYSIS AS A CONSEQUENCE OF EXCESSIVE PHYSICAL ACTIVITY IN CHILDREN AND ADOLESCENTS
Authors: Романюк Федор Петрович , Гончар Наталья Васильевна , Козловская Ольга Васильевна , Моисеенкова Юлия Андреевна , Михальченко Диана Сергеевна
Published: March 2024

Рабдомиолиз остается большой диагностической и лечебно-профилактической проблемой для клиницистов, особенно при работе со спортсменами детского и подросткового возраста. Разнообразная этиология, отсутствие специфических симптомов, поздняя диагностика, развитие системных осложнений ухудшают прогноз заболевания и затрудняют лечение. Рабдомиолиз, связанный с физической нагрузкой, у детей и подростков по своему происхождению относится к нетравматическому, часто обусловлен наследственными причинами и провоцируется на фоне инфекционных заболеваний и нарушений метаболизма. Своевременное проведение корректной инфузионной терапии остается краеугольным камнем лечения рабдомиолиза. Представлен клинический случай успешного лечения подростка с рабдомиолизом, осложненным острым поражение почек.

Rhabdomyolysis remains a major diagnostic and therapeutic and preventive problem for clinicians, especially when working with athletes of child and adolescent age. A diverse etiology, the absence of specifi c symptoms, late diagnosis, the development of systemic complications worsen the prognosis of the disease and complicate treatment. Rhabdomyolysis associated with physical activity in children and adolescents is nontraumatic in origin, is often caused by hereditary causes and is provoked against the background of infectious diseases and metabolic disorders. Timely implementation of correct infusion therapy remains the cornerstone of the treatment of rhabdomyolysis. A clinical case of successful treatment of a teenager with rhabdomyolysis complicated by acute kidney injury is presented.
THE ROLE OF HOMOCYSTEIN IN THE PATHOGENESIS OF ARTERIAL HYPERTENSION IN OBESITY AND COMORBID DISEASES
Authors: Марцева Елизавета Михайловна , Евдокимова Нина Викторовна , Прокопьева Наталья Эдуардовна
Published: March 2024

Гомоцистеин (Гц) — это аминокислота, которая принимает участие в патогенезе артериальной гипертензии (АГ) путем индукции протромботических и провоспалительных эффектов, путем увеличения окислительного стресса, эндотелиальной дисфункции и пролиферации клеток гладких мышц. Однако его роль в развитии АГ при коморбидных патологиях, например при ожирении и связанных с ним нарушениях обменных процессов, изучена недостаточно.

Homocysteine (Hс) is an amino acid that is involved in the pathogenesis of arterial hypertension (AH) by inducing prothrombotic and pro-infl ammatory eff ects, by increasing oxidative stress, endothelial dysfunction and smooth muscle cell proliferation. However, its role in the development of hypertension with comorbid pathologies, such as obesity and related metabolic disorders, has not been studied enough.
MEDICAL SOVEREIGNTY AND WAYS TO ACHIEVE IT ON THE EXAMPLE OF MINIMALLY INVASIVE GASTROSTOMY
Authors: Гавщук Максим Владимирович
Published: March 2024

Введение. Медицинский суверенитет от импортных расходных материалов является важной составляющей государственного суверенитета. Цель статьи — предложить пути достижения медицинского суверенитета на примере малоинвазивной гастростомии. Материалы и методы. В рамках диссертационной работы проведено теоретическое изучение проблемы, серия экспериментов in vitro и in vivо на лабораторных животных, клиническое исследование. Результаты. Разработаны и апробованы в эксперименте оригинальные приспособления, составляющие в совокупности специализированную трубку для чрескожной эндоскопической гастростомии. Предложена оригинальная технология малоинвазивной гастростомии — минимальная гастростомия через мини-лапаротомию, снижающая зависимость от импортных расходных материалов. Выводы. Представленные оригинальные разработки не только позволят организовать импортозамещение, но и окажут информационное давление на иностранных производителей для сохранения импорта.

Introduction. Medical sovereignty from imported consumables is an important component of State sovereignty. The purpose of the article is to propose ways to achieve medical sovereignty on the example of minimally invasive gastrostomy. Materials and methods. As part of the dissertation work, a theoretical study of the problem, a series of in vitro and in vivo experiments on laboratory animals, and a clinical study were conducted. Results. Original devices have been developed and experimentally tested, which together make up a specialized tube for percutaneous endoscopic gastrostomy. An original technology of minimally invasive gastrostomy is proposed – minimal gastrostomy through minilaparotomy, which reduces dependence on imported consumables. Conclusions. The presented original developments will not only make it possible to organize import substitution, but also exert informational pressure on foreign manufacturers to preserve imports.
The 2nd International Symposium on Continuum Model of Guided Imagery and Music
Authors: Jerling Petra
Published: March 2024

The 2nd International Symposium on Continuum Model of Guided Imagery and Music23-24 October 2021, online
Lesbian, gay, bisexual and trans individuals living with dementia: Concepts, practice and rights (Westwood & Price, Eds.)
Authors: Guise Vicky
Published: March 2024

This is a review of the book "Lesbian, gay, bisexual and trans individuals living with dementia: Concepts, practice and rights" edited by Sue Westwood and Elizabeth Price

Title: Lesbian, gay, bisexual and trans individuals living with dementia: Concepts, practice and rights Editors: Sue Westwood & Elizabeth Price Publication year: 2018 Publisher: Routledge Pages: 241 ISBN: 978-1-138-34334-4
Conceptual Profile of Older-Person-Centred Care Within the General Framework of Person Centred Medicine
Authors: Uzcátegui-Martínez Mariarí
Published: March 2024

Background: The elderly represents a growing segment of the population for whom person-centred medicine (PCM) has been pointedly argued as highly relevant. This is due to demographic weight, clinical complexity, and ethical challenges. Therefore, it should be valuable to elucidate the key elements of person-centred care for this important population. Approaches for doing this may include analyses of aging-related studies selected from general populationstudies engaged for the systematic conceptualisation of PCM.

Objectives: The purpose of this study was to delineate the conceptual profile of person-centred care for older people within the general framework of PCM.

Methods: The main methodological approach employed in the present study was analyses of older-person studies selected from a large set of general population studies reviewed towards exploring the systematic conceptualization of PCM. That general study yielded eight principles as follows: (1) Ethical Commitment, (2) Cultural Sensitivity, (3) Holistic scope, (4) Relational Focus, (5) Individualised Care, (6) Common Ground for Collaborative Diagnosis andCare, (7) People-centred Systems of Care, and 8) Person-centred Education and Research.

Results: It was found that the eight principles of PCM elucidated for the general population were present in older-person-centred care papers, although to various degrees across principles. It was evidenced that the principles on Ethical Commitment, Holistic Framework, Relationship Focus, Individualised Care, and Person-centred Education and Research had the greatest presence in the articles on older-person-centred medicine.

Discussion: The considerable consistency found between the conceptual profile of person-centred care for older persons and the principles of PCM in the general population may reflect that the PCM perspective was historically pioneered within the old-age health field and that the PCM perspective continues to attract enormous interest in the old age field. This is highlighted by the fact that ethical commitment was a key motivator for the pioneering development of PCM in the geriatric field and that this principle has been prominently identified in recent systematic conceptualisation studies of PCM for the general population and appears as well among recent academic developments and proposals from major international institutions.

Conclusions: The fundamental characteristics of older-person-centred care appear to have considerable consistency with the general principles of PCM, with particular attention to ethical commitment, holistic framework, communicative and relational focus, and attention to the values and needs of the older persons involved.
Innovative Curriculum Model for Person Centered Medical Education
Authors: Perez-Miranda Juan , Caballero Martinez Fernando
Published: March 2024

The academic medical education model of Francisco de Vitoria University (UFV) was presented at the Jim Appleyard Memorial 14th Geneva Conference on person cenetred medicine in April 2022. The objective of creating a new medical education model aimed at training person-centered physicians and how it was articulated in the curriculum is the main purpose of this short manuscript. The main characteristics and foundational ideas inspiring this model are presented.
The Use of Syntactic Information in Fake News Detection: A Systematic Review
Authors: Fagundes Matheus José Garcia , Roman Norton Trevisan , Digiampietri Luciano Antonio
Published: March 2024

Fake news has been a critical problem for society, to the extent that its damaging effects can already be seen in several areas, such as democracy and health. However, as fake news grow in number, manual fact-checking becomes impractical for identifying them, which makes automatic detection a compelling alternative. In this sense, this study gathers multiple solutions for the problem of automatically detecting fake news, through the usage of both lexical and syntactic information. This study consists of a systematic review on fake news detection through linguistic patterns, focusing on the use of syntax to aid in the task. Solving complex problems by capturing linguistic patterns is mostly explored in the Natural Language Processing (NLP) area. In general, the use of shallow syntax representations, such as Parts of speech, only marginally increases the performance of classifiers in this task. However, relying on deeper syntactic representations, such as context-free grammars or syntactic dependency trees, present more promising results.
Severe Acute Hepatitis of Unknown Etiology in Pediatric Patients: Multidisciplinary Clinical Approach
Authors: Medina Mendoza Jessica , Gómez-Romero Laura , Fernández Sánchez Veronica , Ibáñez-Cervantes Gabriela , Bello-López Juan Manuel , Cortés Vargas Astrid , Alvarez-Jiménez Violeta Dejanira , Gomez Zamora Erika , Cedro-Tanda Alberto , Alethia Cureno-Diaz Monica
Published: March 2024

Introduction: In mid-2022, the World Health Organization (WHO) declared a moderate-risk outbreak due to an increase in severe acute hepatitis cases of unknown etiology in children. Several reports suggested a viral infection link, with the outbreak spanning over 35 countries. By June 2022, Mexico reported 69 probable cases across 5 entities to the WHO. Case Presentation: A 4-year-old boy presented with vomiting, jaundice, choluria, and hepatomegaly. A multidisciplinary approach was employed, using an algorithm developed exclusively for clinical, epidemiological, and biochemical follow-up. Despite the negative identification of any associated microorganism and the absence of antibodies, liver function tests remained elevated. A fine needle liver biopsy was performed for diagnostic support, followed by histopathological study and sequencing and analysis of the complete high-depth transcriptome. Transcriptome analysis identified dysbiosis-related intestinal microbiota, including increased enterogenic and opportunistic pathogenic bacteria of the genus Clostridium, as well as HERV-K113, implicated in autoimmune disease development. Conclusions: The study's findings suggest possible immune-mediated mechanisms involving dysbiosis of the gut microbiota and the potential role of HERV-K113. Management and control of acute liver disease depend on specific causes, with the main challenge being early determination and implementation of optimal management strategies. The exact pathological mechanisms underlying pediatric acute hepatitis of unknown etiology remain elusive, warranting further studies to confirm or refute these hypotheses and elucidate the underlying pathological mechanisms
Renal Fibrosis and Oxidative Stress Induced by Silica Nanoparticles in Male Rats and Its Molecular Mechanisms
Authors: Aouey Bakhta , Boukholda Khadija , Ciobica Alin , Burlui Vasile , Soulimani Rachid , Chigr Fatiha , Fetoui Hmadi
Published: March 2024

Background: The utilization of amorphous silica nanoparticles (SiNPs) is gaining popularity in various applications, but it poses a potential risk to human and environmental health. However, the underlying causes and mechanisms of SiNPs-induced kidney damage are still largely unknown. Objectives: This study aimed to investigate the SiNPs-induced damage in the kidney and further explore the possible mechanisms of SiNPs-induced nephrotoxicity. Methods: Thirty adult male rats were divided into 3 different groups. Rats in groups 2 and 3 were administered SiNPs at 2 dosage levels (25 and 100 mg/kg of body weight), while the rats in the control group received no treatment for 28 days. Reactive oxygen species (ROS), antioxidant enzyme activities (glutathione peroxidase [GPx], superoxide dismutase [SOD], and catalase [CAT]), glutathione (GSH) levels, and oxidation markers (such as lipid peroxidation [malondialdehyde (MDA)] and protein oxidation [protein carbonyl (PCO)]) were analyzed in the kidney tissue. Additionally, renal fibrogenesis was studied through histopathological examination and the expression levels of fibrotic biomarkers. Results: The findings revealed that in vivo treatment with SiNPs significantly triggered oxidative stress in kidney tissues in a dose-dependent manner. This was characterized by increased production of ROS, elevated levels of MDA, PCO, and nitric oxide (NO), along with a significant decline in the activities of SOD, CAT, GPx, and reduced GSH. These changes were consistent with the histopathological analysis, which indicated interstitial fibrosis with mononuclear inflammatory cell aggregation, tubular degeneration, glomerulonephritis, and glomerular atrophy. The fibrosis index was confirmed using Masson's trichrome staining. Additionally, there was a significant upregulation of fibrosis-related genes, including transforming growth factor-beta 1 (TGF-β1), matrix metalloproteinases 2 and 9 (MMP-2/9), whereas the expression of tissue inhibitor of metalloproteinase 2 (TIMP2) was downregulated. Conclusions: This study provided a new research clue for the role of ROS and deregulated TGF-β signaling pathway in SiNPs nephrotoxicity.
Lisansüstü eğitimin ekonomik büyümeye etkisi: Türkiye örneği (1983-2021)
Authors: Yılmaz Zeki , Mammadov Taleh
Published: March 2024

Çağdaş içsel büyüme modellerinde beşeri sermayenin ekonomik büyüme ve kalkınmadaki rolü ilk olarak inceleme konusu yapılmıştır. Literatürde beşeri sermaye olarak lisansüstü eğitimi dikkate alan çalışmaların azlığı, çalışma ile bu eksikliğe katkı yapması amaçlanmıştır. Çalışmada Türkiye’de 1983-2021 dönemi yıllık olarak, doktora ve yüksek lisans mezunlarının ekonomik büyüme üzerindeki etkisi incelenmiştir. İlk olarak geleneksel Granger ve Johansen eşbütünleşme testi ile analiz gerçekleştirilmiştir, ancak herhangi bir eşbütünleşme ilişkisi tespit edilememiştir. Bu nedenle Granger ve Yoon (2002) geliştirdiği saklı eşbütünleşme yöntemi ile değişkenlerin pozitif ve negatif şokları ayrıştırılarak tekrar analiz edilmiştir. Analiz bulgularına göre yüksek lisans mezunlarında meydana gelen %1’lik pozitif gelişme, ekonomik büyümeyi pozitif yönde %0.38 oranında arttırmaktadır. Aynı şekilde doktora mezunları değişkeninde meydana gelen %1’lik bir olumsuz gelişme, ekonomik büyümedeki olumsuzlukları %0.21 arttırdığı sonucuna ulaşılmıştır.
Comparison of the WHO classification (5th edition) 2022 and the International Consensus Classification (ICC) 2022 for diagnosis of acute myeloid leukemia)
Authors: Al-Nakkash Naba , Frenzel Lukas P.
Published: March 2024

In 2022, two classifications were published to define the diagnosis of patients with acute myeloid leukemia (AML). The World Health Organisation (WHO) 5th edition and the International Consensus Classification (ICC) provide an updated summary of current knowledge of the diseases and construct a framework for physicians. Two differing classifications result in discrepancies, which change the definition of AML subtypes and present a challenge in clinical settings. This work summarizes the updated classification systems and discusses their significance in clinical settings while considering the latest findings. Relevant changes affect the i) required blast percentage, ii) AML harbouring CEBPA mutations, iii) AML with KMT2A and MECOM rearrangements, iv) AML with myelodysplasia-related characteristics and in association with this entity AML with mutated RUNX1, and lastly v) AML with TP53 mutation. In summary, a unified classification system would be desirable to achieve harmonized diagnosis and treatment of AML).
Hermeneutical Rhetoric and Interpretations of ‘Our Common Home’
Authors: Petre Elizabeth A. ,   Religious Communication Association
Published: March 2024

Pope Francis’s encyclical Laudato Si’: On Care for Our Common Home represents a sweeping call for action on climate change. In this essay, I use hermeneutical rhetoric to explore the rhetorical strategies Pope Francis employed. In particular, I critically analyze each of the six chapters in the encyclical, focusing on the use of the phrase “our common home.” I argue that Pope Francis’s reinterpretation of the relationship among humans, God, and the environment positions efforts to address climate change as a moral imperative.
Ecology Meets Integral Ecology Meets Media Ecology
Authors: Loffredo Roca Maria F. , Corcoran Peter Blaze ,   Religious Communication Association
Published: March 2024

Laudato Si’: On Care for Our Common Home has struck a deep chord with a broad audience. We explore the synergy between the ethical vision of sustainability in the Earth Charter and the encyclical. We position the document within the ecology and media landscapes. Laudato Si’ is remarkable among international statements in its explicit attention to education. We draw out the pivotal importance of education in order for its critical message not to be lost. We argue that education for Laudato Si’ can be advanced in traditional education—formal and non-formal, secular and religious—and in education through the media.
Reactualization of Marriage Law in Indonesia on the Issue of Marriage Annulment in Achieving Legal Certainty
Authors: Sa'adah Nur , Junaedi Junaedi , Sailellah Sirajuddin
Published: March 2024

The annulment of marriage based on Law Number 1 of 1974 has not provided clarity, so it can cause legal uncertainty and injustice. Article 22 of Law Number 1 of 1974 states that a marriage can be annulled if the parties do not meet the conditions for consummating the marriage. This dissertation is to examine and analyse the implementation of Law Number 16 of 2019 concerning Amendments to Law Number 1 of 1974 concerning Marriage in the problem of marriage annulment and to study, analyse, and find legal certainty in the actualisation of Law Number 16 of 2019 concerning Amendments to Law Number 1 of 1974 concerning Marriage in the Prevalence of Marriage Annulment. This research uses a normative approach with the type of analytical descriptive research including legal principles, synchronisation of laws and regulations, including efforts to form law (rechtsvorming), the source of legal materials used is primary legal material, secondary legal material (secondary data) which will be obtained through literature sources. The results of the study show that there are still many violations of the Marriage Law, such as marriage registration, underage marriage, wild polygamy and illegal divorce because they have not explicitly and firmly regulated the annulment of marriage. Implementing the Marriage Law must prioritise the principle of justice, especially regarding marriage annulment. This includes the annulment of marriages involving imperfections of reason, marriages under threat of law, or marriages that violate religious law. In the actualisation of marriage law to overcome the problem of marriage annulment, it is important to strengthen legal certainty. First, the actualisation of the Marriage Law is a proactive step needed to address the issue of marriage annulment. This includes adequate articles to regulate situations that might lead to marriage annulment. Second, the Protection of Individual Rights.