bluuebunny/crossref_metadata_2025 huggingface dataset:
Kas İskelet Sistemi Değerlendirilmesinde Kullanılan Özel Testler: Geçerlik, Duyarlık Ve Özgüllük
Authors:   Bandırma Onyedi Eylül Üniversitesi, Sağlık Bilimleri Fakültesi, Türkmen Ezgi , Şahin Altaç Duygu , Keçelioğlu Şule , Şenel Aybike , Birinci Tansu , Mustafaoğlu Rüstem , Atakan Meltem Besim , Sanır Rabia , Türkmen Ozan Bahadır , Ataş Kübra , Karabörklü Argut Sezen
Published: November 2023

Güvenilirlik, bir testin tekrarlanabilirliği ve sonuçların tutarlılığı ile ilgilidir. Kısaca, aynı testin farklı günlerde veya farklı sağlık profesyonelleri tarafından yapıldığında aynı sonuçları vermesi anlamına gelir. Bu nedenledir ki, güvenilirlik testin doğru sonuçlar verme yeteneğini değil, test sonuçlarının tekrarlanabilirliğini ölçer. Sonuç olarak, bir testin güvenilirliği, testin doğru bir şekilde yorumlanması ve kullanılması kadar önemlidir. Ayrıca, bir testin güvenilirliği yüksek olabilir ancak duyarlılığı veya özgüllüğü düşük olabilir. Duyarlılık, bir testin ne kadar doğru sonuçlar verdiğini değerlendirmede önemlidir. Bir testin duyarlılığı, testin patolojiyi doğru bir şekilde tanımlama veya patolojinin varlığını doğru bir şekilde tespit etme yeteneğidir. Yani, bir testin duyarlılığı, gerçek hastaların ne kadarını doğru bir şekilde tespit edebildiğini gösterir. Özetle, bir testin duyarlılığı, testin yanlış negatif sonuç verme olasılığını azaltır. Ancak, testin yanlış pozitif sonuçlar verme olasılığı gibi diğer faktörleri de değerlendirmek önemlidir. Ayrıca, bir testin duyarlılığı, testin doğru bir şekilde kullanılması ve doğru talimatların takip edilmesi ile artırılabilir. Özgüllük, testin gerçek negatif sonuçları doğru bir şekilde belirleme yeteneğini ölçer. Özetle; bir testin sağlıklı bireyleri doğru şekilde ayırt etme yeteneği ile ilgilidir. Yani, bir testin, sağlıklı insanlara yanlış pozitif sonuçlar vermemesi ve hastalık olmayan kişileri yanlış şekilde tanımlamaması beklenir. Ayrıca, özgüllük, testin güvenilirliği ve geçerliliği için de önemlidir. Özgüllük, testin doğru sonuçlar verme kabiliyetini artırarak, testin güvenilirliğini ve geçerliliğini artırır. Aynı zamanda, testin kullanımını kolaylaştırarak, yanlış sonuçlara bağlı gereksiz testlerin yapılmasını azaltır. Pozitif olabilirlik oranı (positive likelihood ratio) bir özel testin doğruluğunu değerlendirmek için kullanılan bir istatistiksel ölçüttür. Pozitif olabilirlik oranı, bir test sonucunun gerçekten pozitif olan kişilerde (hastalığı olanlar) test sonucunun pozitif çıkması olasılığını, gerçekten negatif olan kişilerde (hastalığı olmayanlar) test sonucunun pozitif çıkması olasılığına bölerek hesaplanır.
El ve El Bileği Eklemi
Authors:   Bandırma Onyedi Eylül Üniversitesi, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Bölümü, Balıkesir, Türkiye, Keçelioğlu Şule , Kaya Mutlu Ebru ,   Bandırma Onyedi Eylül Üniversitesi, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Bölümü, Balıkesir, Türkiye
Published: November 2023

Günlük yaşamamızda birçok aktivitenin gerçekleştirilmesini sağlayan el ve el bileği eklemi, anatomisi itibariyle hem özel bir yapıya sahiptir hem de beyinde temsil alanı oldukça geniştir. El ve el bileği ekleminde eklemi oluşturan kemik yapıyı, eklemi, eklem çevresindeki liga- mentleri-kasları, sinir ve damar yapısını içeren patolojiler görülebilmekte ve bu patolojiler önemli problemlere neden olabilmektedir. Bu bağlamda doğru tanının konulması önemlidir ve patolojilerin tespitinde özel testlemeler kullanılmaktadır. El ve el bileği eklemine yönelik lit- eratürde çok sayıda özel testleme mevcuttur. Patolojiye özgü olarak farklı yazarlar tarafından testler için farklı duyarlılık ve özgüllük değerleri bildirildiği gibi bazı testler için henüz bu değer- ler tanımlanmamıştır. İleride el ve el bileği eklem problemleri için daha fazla sayıda çalışma yapılması gerektiği literatür incelemeleri sonucu tespit edilmiştir.
RELAÇÃO ENTRE TRANSTORNO DISMÓRFICO CORPORAL E NECESSIDADE DE TRATAMENTOS ESTÉTICOS: REVISÃO SISTEMÁTICA
Authors: Campos João Heli , Cutuli Carlos A
Published: November 2023

Objetivo: destacar a relação entre o Transtorno Dismórfico Corporal (TDC) de alta prevalência e os procedimentos estéticos faciais por meio de uma revisão sistemática da literatura. Métodos: A busca nas bases PubMed, SciELO, ScienceDirect e BVS ocorreu em 19/08/2023. Foram usados os termos Mesh/Decs na PubMed, ScienceDirect e BVS/Medline: Body Dysmorphic Disorder, Aesthetic Procedures, Face e diagnosis. Na SciELO: Transtorno Dismórfico Corporal, Procedimentos Estéticos, Insatisfação Corporal, Imagem Corporal e Cirurgia Plástica. Na PubMed obtiveram-se 15 resultados, destes 6 foram eleitos. Na SciELO uma busca nos últimos 4 anos obteve 4 resultados, destes 3 foram eleitos. Na ScienceDirect nos últimos 10 anos para arquivos de acesso livre foram obtidos 47 resultados, destes foram eleitos 12. Na BVS obteve 35 resultados e 8 foram eleitos. Somando os registros eleitos resultou em 29 e por 8 registros aparecem em mais de uma base apenas 21 foram usados na síntese.  Resultados: O lapso temporal entre os 21 artigos eleitos para síntese foi de 8 anos compreendendo artigos publicados entre 2016 e 2023. O número de participantes nos 21 registros foi de 3,163, cinco artigos (23,8%) não mencionaram o gênero dos participantes, quatro artigos (19%) o total dos participantes era do gênero feminino. A síntese mostrou que dentre as medidas usadas as mais frequentes foram os questionários ⁶BDD-YBOCS, ¹⁴BDDE e ¹⁴BDDE. A prevalência estimada de TDC na população geral foi entre 1% e 2,5%.  A prevalência entre adolescentes é um pouco mais alta podendo chegar a 3,6%. Quatro dos artigos (19%) não fizeram menção quanto à prevalência na população geral e três deles apresentaram a prevalência estimada em adolescentes. Conclusão: os profissionais de estética devem estar cientes de que o TDC é uma contra-indicação à realização de tratamentos estéticos. Estes pacientes têm forte tendência de ocultar a natureza de seu desejo e se submetem a qualquer procedimento. A abordagem multidisciplinar pode instituir o diagnóstico precoce evitando insatisfação com o resultado, comportamentos violentos contra o profissional e ações judiciais. O diagnóstico e a terapêutica cabem aos profissionais da psicologia e psiquiatria.
PREVENÇÃO, DIAGNOSTICO, PRECOCE E NOTIFICAÇÃO DE CASOS DA HANSENÍASE NO BRASIL, NO PERÍODO DE 2020 A 2022
Authors: Jesus Talia Martins de , Santos Francine Pinto dos
Published: November 2023

A hanseníase é classificada como uma doença infecciosa causada por uma bactéria (Mycobacterium leprae), além de ser contagiosa tem evolução crônica, que afeta os nervos e a pele. houve um impacto entre os anos de 2020 a 2022 por conta da COVID-19, e com isso ocasionou vários reajustes em diversas situações, por exemplo na área da saúde. Este estudo tem como objetivo identificar as medidas preventivas, diagnóstico precoce e as notificações de casos da hanseníase no Brasil, durante o período pandêmico. A metodologia adotada é um estudo místico e baseia-se em uma pesquisa de revisão literária de escopo, com o auxílio de levantamento bibliográfico disponíveis em artigos científicos Biblioteca virtual em saúde, Scielo, Datasus e Google Academy. Os resultados deste trabalho foram relatados através de dados onde os quais demostram os impactos ocorridos havendo a minimização das ações preventivas e dificuldades no procedimento do diagnostico, dentre os três anos de estudo, em 2021 foi o ano que teve a menor notificação de casos em seguida 2020 e logo após 2022. Conclui-se que através do decorrer do desenvolvimento do trabalho, que houve empecilhos nas demandas abordadas, gerando o decaimento do diagnóstico de novos casos da doença. Vale enfatizar que esse estudo procura identificar quesitos, os quais agregue soluções para as dificuldades ocorridas, através de proporções de medidas cabíveis mais reforçadas.
A IMPORTÂNCIA DA ENFERMAGEM PARA A DIMINUIÇÃO DA MORTALIDADE NEONATAL
Authors: Lima Ester Paula Sousa , Andrade Jaqueline Gomes Rosa Silva de , Almeida Lívia Aragoso de , Sá Naiara Jéssica de , Alves Nathaly Rhaiane Marinho de Oliveira  , Lopes Victoria Maria Martins , Almeida Zulema Maria Aguiar
Published: November 2023

A prematuridade é classificada quando um neonato nasce com o número inferior a 37 semanas de gestação; diante isto o recém-nascido necessita de vários cuidados, já que seu nascimento foi realizado antes do previsto, por isso a equipe de enfermagem em conjunto com a família apresenta uma grande importância para o tratamento e desenvolvimento desse recém-nascido. Objetivou-se descrever como a equipe profissional de enfermagem é marcante para os cuidados e como o seu cuidado afeta o tratamento e desenvolvimento neonatal; ademais, foi destacado a epidemiologia, a definição de prematuridade, a mortalidade e a importância da enfermagem. Nesse sentido é indiscutível que, há uma grande relevância entre a equipe de enfermagem, multiprofissional e a família participam ativamente para desenvolvimento do neonato. Pois mesmo se tratando de seres sensíveis, os óbitos podem ser evitados em muitos casos quando a assistência é prestada de forma. Assim é mostrado no artigo os principais cuidados para a diminuição de óbitos, após a percepção da necessidade da atualização dos profissionais de saúde; logo que, tal profissional necessita de uma abordagem eficácia e eficiência para que o recém-nascido sobreviva sem sequelas e saudável.  A metodologia utilizada foi à revisão de literatura baseada nos sites como: Scielo, Redalyc e livro referente ao tema. Conclui-se que o profissional de enfermagem deve estar apto para realizar as intervenções necessárias, empregando todo o conhecimento técnico/científico adquirido durante sua carreira e capacitação, para conduzir a melhor assistência ao neonato.
Milk-y Way: the impact of single-nucleotide polymorphisms on milk production traits in Kilis dairy goats
Authors: Gündüz Zühal , Biçer Osman
Published: November 2023

Abstract. This study aimed to investigate the impact of single-nucleotide polymorphisms (SNPs) on milk production traits in Kilis dairy goats by analyzing the genotypes of POU1F1, PRLR, β-Lg, GH1, and GH2 genes and their association with lactation milk yield (LMY), lactation length (LL) and average daily milk yield (ADMY). Blood samples were collected from 227 goats, and genotyping was performed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The results revealed that the frequencies of the genotypes varied among the genes. The polymorphisms were found to be significantly linked with milk production traits. These findings suggest that SNPs of POU1F1/AluI, PRLR/RsaI and β-Lg/SacII are significantly associated with LMY and that the POU1F1-TC genotype, PRLR-TT genotype and β-Lg-AB genotype are associated with higher LMY and ADMY. Additionally, the POU1F1-TC genotype was found to have a longer LL. However, no significant association was found between the GH1 and GH2 genotypes and LMY, LL and ADMY. Overall, this study provides valuable insights into the genetic factors influencing milk production traits in Kilis dairy goats, which can be utilized for the selection of high-yielding animals in breeding programs.
Two years of satellite-based carbon dioxide emission quantification at the world's largest coal-fired power plants
Authors: Cusworth Daniel H. , Thorpe Andrew K. , Miller Charles E. , Ayasse Alana K. , Jiorle Ralph , Duren Riley M. , Nassar Ray , Mastrogiacomo Jon-Paul , Nelson Robert R.
Published: November 2023

Abstract. Carbon dioxide (CO2) emissions from combustion sources are uncertain in many places across the globe. Satellites have the ability to detect and quantify emissions from large CO2 point sources, including coal-fired power plants. In this study, we routinely made observations with the PRecursore IperSpettrale della Missione Applicativa (PRISMA) satellite imaging spectrometer and the Orbiting Carbon Observatory-3 (OCO-3) instrument aboard the International Space Station at over 30 coal-fired power plants between 2021 and 2022. CO2 plumes were detected in 50 % of the acquired PRISMA scenes, which is consistent with the combined influence of viewing parameters on detection (solar illumination and surface reflectance) and unknown factors (e.g., daily operational status). We compare satellite-derived emission rates to in situ stack emission observations and find average agreement to within 27 % for PRISMA and 30 % for OCO-3, although more observations are needed to robustly characterize the error. We highlight two examples of fusing PRISMA with OCO-2 and OCO-3 observations in South Africa and India. For India, we acquired PRISMA and OCO-3 observations on the same day and used the high-spatial-resolution capability of PRISMA (30 m spatial/pixel resolution) to partition relative contributions of two distinct emitting power plants to the net emission. Although an encouraging start, 2 years of observations from these satellites did not produce sufficient observations to estimate annual average emission rates within low (<15 %) uncertainties. However, as the constellation of CO2-observing satellites is poised to significantly improve in the coming decade, this study offers an approach to leverage multiple observation platforms to better quantify and characterize uncertainty for large anthropogenic emission sources.
The transition to new ozone absorption cross-sections for Dobson and Brewer total ozone measurements
Authors: Voglmeier Karl , Velazco Voltaire , Egli Luca , Gröbner Julian , Redondas Alberto , Steinbrecht Wolfgang
Published: November 2023

Abstract. Comparison of total ozone column (TOC) measurements from ground-based Dobson and Brewer spectrophotometers and from various satellite instruments generally reveals seasonally varying differences of a few percent. A large part of these differences has been attributed to the operationally used Bass & Paur ozone cross-sections and the lack of accounting for varying stratospheric temperatures in the standard total ozone retrieval for Dobson. This paper demonstrates how the use of new ozone absorption cross sections from the University of Bremen (Weber et al., 2016), as recommended by the committee on Absorption Cross-Sections of Ozone, the application of appropriate slit functions, especially for the Dobson instrument (Bernhard et al. 2005), and the use of climatological values for the effective ozone layer temperature (Teff), e.g. from TEMIS, essentially eliminate these seasonally varying differences between Dobson and Brewer total ozone data. Applying this approach to the existing global network of Dobson spectrometers will reduce the uncertainty of their total ozone data, from previously 3 to 4 % to better than 2.0 % at most locations.
Using machine learning to construct TOMCAT model and occultation measurement-based stratospheric methane (TCOM-CH4) and nitrous oxide (TCOM-N2O) profile data sets
Authors: Dhomse Sandip S. , Chipperfield Martyn P.
Published: November 2023

Abstract. Monitoring the atmospheric concentrations of greenhouse gases (GHGs) is crucial to improve our understanding of their climate impact. However, there are no long-term profile data sets of important GHGs that can be used to gain a better insight into the processes controlling their variations in the atmosphere. In this study, we apply corrections to chemical transport model (CTM) output based on profile measurements from two solar occultation instruments: the HALogen Occultation Experiment (HALOE) and the Atmospheric Chemistry Experiment – Fourier Transform Spectrometer (ACE-FTS). The goal is to construct long-term (1991–2021), gap-free stratospheric profile data sets, hereafter referred to as TCOM, for two important GHGs. To estimate the corrections that need to be applied to the CTM profiles, we use the extreme gradient boosting (XGBoost) regression model. For methane (TCOM-CH4), we utilize both HALOE and ACE satellite profile measurements from 1992 to 2018 to train the XGBoost model, while profiles from 2019 to 2021 serve as an independent evaluation data set. As there are no nitrous oxide (N2O) profile measurements for earlier years, we derive XGBoost-derived correction terms to construct TCOM-N2O profiles using only ACE-FTS profiles from the 2004–2018 time period, with profiles from 2019–2021 used for the independent evaluation. Overall, both TCOM-CH4 and TCOM-N2O profiles exhibit excellent agreement with the available satellite-measurement-based data sets. We find that compared to evaluation profiles, biases in TCOM-CH4 and TCOM-N2O are generally less than 10 % and 50 %, respectively, throughout the stratosphere. The daily zonal mean profile data sets, covering altitude (15–60 km) and pressure (300–0.1 hPa) levels, are publicly available via the following links: https://doi.org/10.5281/zenodo.7293740 for TCOM-CH4 (Dhomse, 2022a) and https://doi.org/10.5281/zenodo.7386001 for TCOM-N2O (Dhomse, 2022b).
Antarctic Ice Sheet grounding line discharge from 1996 through 2023
Authors: Davison Benjamin Joseph , Hogg Anna Elizabeth , Slater Thomas , Rigby Richard
Published: November 2023

Abstract. Grounding line discharge is a key component of the mass balance of the Antarctic Ice Sheet. Here we present an estimate of Antarctic Ice Sheet grounding line discharge from 1996 through to last month. We calculate ice flux at up to 100 m resolution through 16 algorithmically-generated flux gates, which are continuous around Antarctica. We draw on a range of ice velocity and thickness data to estimate grounding line discharge. For ice thickness, we use four bed topography datasets, two firn models and a temporally varying ice surface. For the ice velocity, we utilise a range of publicly-available ice velocity maps at resolutions ranging from 240 x 240 m to 1000 x 1000 m, as well as new, 100 x 100 m monthly velocity mosaics derived from intensity-tracking of Sentinel-1 image pairs, available since October 2014. The pixel-based ice fluxes and ice flux errors are integrated within all available Antarctic ice stream, ice shelf and glacier basins. Our dataset also includes the contributions to discharge from changes in ice thickness due to surface lowering, time-varying firn air content and surface mass change between the flux gates and grounding line. We find that Antarctic Ice Sheet grounding line discharge increased from 1,990 ± 23 Gt yr-1 to 2,205 ± 18 Gt yr-1 between 1996 and 2023, much of which was due to acceleration of ice streams in West Antarctica but with substantial contributions from ice streams in East Antarctica and glaciers on the Antarctic Peninsula. The uncertainties in our discharge dataset primarily result from uncertain bed elevation and flux gate location, which account for much of difference between our results and previous studies. It is our intention to update this discharge dataset each month, subject to continued Sentinel-1 acquisitions and funding availability. The datasets are freely available at https://zenodo.org/records/10183327 (Davison et al., 2023a).
A sub-grid parameterization scheme for topographic vertical motion in CAM5-SE
Authors: Wang Yaqi , Wang Lanning , Feng Juan , Song Zhenya , Wu Qizhong , Cheng Huaqiong
Published: November 2023

Abstract. Overestimation of precipitation over steep mountains is always a common bias of atmospheric general circulation models (AGCMs). One basic reason is the imperfection of parameterization schemes. Sub-grid topography has a non-negligible role in the dynamics of the actual atmosphere, and therefore the sub-grid topographic parameterization schemes have been the focus of model development. This study proposes a sub-grid parameterization scheme for topographic vertical motion in CAM5-SE (Community Atmospheric Model version 5 with spectral element dynamical core) to revise the original vertical velocity by adding the topographic vertical motion, resulting in a significant improvement in simulations in precipitation over steep mountains. The results show a better improvement in precipitation simulation in steep mountains, such as the steep edge of the Tibetan Plateau and the Andes. The positive deviations of the precipitation on the mountain tops and the negative deviations in the windward slope are revised. The improved scheme of topographic vertical motion reduces the model biases of summer mean precipitation simulations by up to 48 % (6.23 mm d−1) on the mountain tops. The improvement in convective precipitation (4.83 mm d−1) contributes the most to the improvement in the total precipitation simulation. In addition, we extend the dynamic lifting effect of topography from the lowest layer (Single experiment) to multiple layers, approaching the bottom model layers (Multi experiment). Moreover, the water vapor transport in low-altitude regions in front of the windward slope is also considerably improved, leading to simulations of much more realistic circulation patterns in the multi-layer scheme. Since the sub-grid parameterization scheme addresses the more detailed problem caused by topography, the water vapor is transported further to the northwest in the multi-layer scheme. The topographic vertical motion schemes in both the Single and Multi experiments can improve the model performance in simulating precipitation in all regions with complex terrain.
Relative dispersion and kinematic properties of the coastal submesoscale circulation in the southeastern Ligurian Sea
Authors: Poulain Pierre-Marie , Centurioni Luca , Brandini Carlo , Taddei Stefano , Berta Maristella , Menna Milena
Published: November 2023

Abstract. An array of Lagrangian instruments (more than 100 drifters and a profiling float) were deployed for several days in the coastal waters of the southeastern Ligurian Sea to characterize the near-surface circulation at the submesoscale (< 10 km). The drifters were trapped in an offshore-flowing filament and a cyclonic eddy that developed at the southwestern extremity of the filament. Drifter velocities are used to estimate differential kinematic properties (DKPs) and the relative dispersion of the near-surface currents on scales as small as 100 m. The maximum drifter speed is ∼ 50 cm s−1. The DKPs within the cluster exhibit considerable spatial and temporal variability, with absolute values reaching the order of magnitude of the local inertial frequency. Vorticity prevails in the core of the cyclonic eddy, while strain is dominant at the outer edge of the eddy. Significant convergence was also found in the southwestern flow of the filament. The initial relative dispersion on small scales (100–200 m) is directly related to some of the DKPs (e.g., divergence, strain and instantaneous rate of separation). The mean squared separation distance (MSSD) grows exponentially with time, and the finite-size Lyapunov exponent (FSLE) is independent of scale. After 5–10 h of drift or for initial separations greater than 500 m, the MSSD and FSLE show smaller relative dispersion that decreases slightly with scale.
Legal grounds and ethical conditions of alternative forms of criminal law conflict resolution in Russia
Authors: Anna Aleksandrovna Dmitrieva , Pavel Sysoevich Pastukhov , Dinara Zholaushobaevna Gostkova
Published: November 2023

The article’s primary purpose is to reveal the potential of alternative forms of resolution of criminal law conflict in Russia’s criminal and criminal procedure legislation. The scientific approach of the authors consists of conducting a comprehensive comparative legal analysis of the norms of international acts and foreign legislation regulating conciliation procedures in criminal proceedings. The scientific novelty lies in the systematic analysis of changes in the humanization of criminal proceedings in all countries based on recommendations developed by the international community. The methodological basis of the study was a set of methods of scientific cognition, among which the dialectical method occupies a leading place, which allowed for identifying the grounds, conditions, essential features, signs and ethical foundations of alternative forms of resolving criminal law conflict. Combining scientific cognition methods in research creates prerequisites for an objective and comprehensive approach to the identified problems. Based on general scientific dialectical methods of analysis, synthesis, abstraction, and concretization, as well as private, scientific comparative legal and technical legal methods, the authors concluded the importance attached to conciliation procedures, which have become an integral part of the legal system of the vast majority of countries. The authors argue that the institution of compromise in criminal proceedings is the core of alternative forms of resolution of criminal conflict in Russia. The author’s concept of the formation of ethical conditions for alternative forms of resolution of criminal law conflict is a system of application of various means and methods, which contributes to the simplification and cheapening of the criminal process. The authors argue that such a technique as a compromise allows for minimizing all possible material costs and, most importantly, effectively implementing the purpose of criminal proceedings to protect the victim’s rights. The development concept aims to develop new approaches to organizing the activities of the investigative bodies and the court to conduct conciliation procedures, which should encourage the accused to exhibit positive behavior and contribute to its correction. The ethical basis of the procedural compromise consists of such features as the proof of the circumstances of the criminal act, the achievement of contractual truth by inducing the accused to active repentance and voluntary repayment of the harm caused. The ethical conditions of alternative forms of resolving the criminal law conflict in Russia create a moral basis for a compromise solution and provide an atmosphere of social trust in society
Editorial
Authors: Gromova Elizaveta , Brantes Ferreira Daniel
Published: November 2023

We present a Special Issue, “Technologies and Dispute Resolution,” of the Brazilian Journal for Alternative Dispute Resolution – RBADR. In the digital era, technologies increasingly capture and transform different spheres of our lives. On the one hand, we must admit that the mentioned technologies have the potential to improve the area significantly. That is why conducting research in this area, finding issues of the use of technologies in dispute resolution, and prospects of its development are significant. This issue comprises 17 (seventeen) papers from around the world evidencing the international vocation of the journal. Its five years of existence and the diversity of authors and writings confirm this. We thank all the journal readers, authors, and Editora Fórum from Belo Horizonte for the successful partnership and excellent work.
An overview of International AUB/HMB Guidelines
Authors: Saridogan E
Published: November 2023

Abnormal uterine bleeding (AUB) is estimated to affect approximately 3-30% of women in their reproductive years. There are a number of guidelines from national societies and organisations on this subject. Many aspects of the available guidelines are in agreement with each other, probably due to the use of same published evidence. However, this article demonstrates that there are also major differences on certain subjects. These are likely to be a reflection of variations in clinical practice in different countries, as the differences are difficult explain with emergence of new evidence. Guidelines aim to improve patient care by informing clinical practice, to reduce unwarranted variability and to expedite implementation of effective intervention. The similarities between the guidelines give an opportunity to create international guidelines which may be more influential globally. Such a document would be more widely accepted by the clinicians and women alike, potentially reduce variability of access to the best treatments available and improve the lives of sufferers.
STUDY OF FLAVONOIDS IN CAMEL THORN AND THEIR ACTIVITY IN ANGIOTENSIN-CONVERTING ENZYME REDUCTION
Authors:   Korkyt Ata Kyzylorda University, Kyzylorda city, Republic of Kazakhstan, Niyazova D.Zh. , Espanova I.D. ,   Korkyt Ata Kyzylorda University, Kyzylorda city, Republic of Kazakhstan, Moldanazar A.A. ,   Korkyt Ata Kyzylorda University, Kyzylorda city, Republic of Kazakhstan, Lyubchik S.I. ,   Universidade Lusófona, Lisbon city, Portugal, Appazov N.O. ,   Korkyt Ata Kyzylorda University, Kyzylorda city, Republic of Kazakhstan
Published: November 2023

The article is dedicated to the study of polyphenolic compounds in extracts of camel thorn (Alhagi pseudoalhagi). Using UV spectroscopy and HPLC-MS/MS, the composition and content of flavonoids in camel thorn extracts were determined. Characteristic absorption bands for flavonoids were identified through optical spectroscopy. Data on the substance composition in the extract were obtained using the HPLC-MS/MS method. Semi-quantitative analysis of flavonoids was performed using the internal standard addition method with rutin. More than twenty flavonoids were detected in the 70% ethanolic extract. Rhamnetin 3-neohesperidoside and Isorhamnetin 3-neohesperidoside were the major components. The results could be applied in the production of antioxidant pharmaceuticals in the pharmaceutical industry. Comparison of the effects of camel thorn extract with the flavonoid taxifolin showed that the extract is equally effective in preventing early stages of atherosclerosis in the aorta caused by increased angiotensin-converting enzyme activity. At an extract concentration of 0.2%, the activity of the angiotensin converting enzyme in elderly rats and an imals treated with a NO-synthase inhibitor decreases to the values of young control rats.
SYNTHESIS OF NEW AMIDOPHOSPHATES BASED ON AROMATIC AMINES
Authors:   Kazakh National Women‘s Teacher Training University, Almaty city, Kazakhstan, Dzhiembaev B.Zh. , Kuandykova A.B. ,   Kazakh National Women‘s Teacher Training University, Almaty city, Kazakhstan
Published: November 2023

Несмотря на впечатляющие успехи, достигнутые в области синтеза и изучения свойств амидофосфатов, соединения данного класса постоянно привлекают внимание исследователей разнообразием путей химических превращений и перспективой использования их в различных областях науки и техники. Этот класс фосфорорганических соединений проявляют различную биологическую и другие виды активности, что стимулирует разработку новых способов синтеза их полифункциональных производных. Возможности химических модификаций амидофосфатов, с введением фармакофорных, конфигурационно индивидуальных групп к их -центру, имеют широкие перспективы в плане получения на их основе биологически активных соединений для нужд медицины, сельского хозяйства и техники. Кроме того, амидофосфаты представляют интерес и для изучения теоретических вопросов органической химии, связанных с некоторыми особенностями химических и биологических свойств, которые определяются влиянием азотного и фосфорного фрагментов. Таким образом, развитие исследований в области разработки методов синтеза новых функционально замещенных производных амидофосфатов, установление их строения, а также поиск в их ряду перспективных биологически активных соединений являются современными и актуальными. В результате реакции 3-метоксифениламина и 2-метоксифенилэтил-амина с диалкилфосфитами в присутствии ССl4 и триэтиламина, реализуемой в классических условиях реакция Атертона-Тодда, были получены и охарактеризованы новые амидофосфаты. Структура амидофосфатов установлена на основании данных ИК, ЯМР 31Р, 1Н, 13С - спектроскопии и элементного анализа.
Inedita, t. 4: Dydaktyka
Authors: Twardowski Kazimierz
Published: November 2023

Tom zawiera niepublikowane dotąd bądź dawno niewznawiane prace Kazimierza Twardowskiego z zakresu dydaktyki. Do pierwszej grupy należą wykłady z dydaktyki ogólnej, wygłoszone w Uniwersytecie Lwowskim w roku akademickim 1902/1903, pisma dotyczące programów szkolnictwa podstawowego i niższego, a także wykład o historii uniwersytetów i wersje słynnego odczytu „O dostojeństwie uniwersytetu”. Do grupy drugiej należy przede wszystkim dydaktyczna część znakomitego podręcznika dla nauczycieli szkół podstawowych, wydanego w roku 1901. Publikowane w tomie pisma pozwalają docenić dorobek Twardowskiego w zakresie pedagogiki i dydaktyki ogólnej. Przedstawił on nie tylko gruntowne analizy pewnych pojęć z zakresu psychologii uczenia i wychowania, lecz umiał również ująć „zasady dydaktyki” w zwarty system. Wiedział również, jak zastosować te zasady do istniejącego systemu edukacyjnego. Jedna z głównych zasad Twardowskiego głosi wyższość kształcenia formalnego (tj. kształcenia umiejętności samodzielnego myślenia) nad materialnym (tj. przekazywaniem „gotowych” informacji). Jest to zasada uniwersalna i aktualna również dziś, a często ignorowana przy tworzeniu programów szkolnych. Twardowski był ponadto niezłomnym obrońcą niezależności uniwersytetów i strażnikiem ich dostojeństwa, głęboko przekonany, że najważniejszym zadaniem uczonego jest szukanie prawdy naukowej, nie zaś prowadzenie badań dopasowanych do panującej mody czy tym bardziej na zamówienie polityczne. Z tego względu pisma Twardowskiego z zakresu dydaktyki mają nie tylko wartość historyczną, lecz mogą również zainteresować współczesnych badaczy pedagogiki i samych pedagogów działających na wszystkich etapach edukacji.
Bractwo św. Jana Nepomucena przy kościele parafialnym w Krościenku Wyżnym w latach 1770-1914
Authors: Pelczar Roman
Published: November 2023

Bractwo św. Jana Nepomucena było stowarzyszeniem dewocyjnym założonym w 1770 r. za zgodą papieża Klemensa XIV. Działało z przerwami do 1914 roku. Jego strukturę i funkcjonowanie regulował statut, który określał również zakres odpustów dostępnych dla członków. Zobowiązania braci miały charakter religijny, społeczny i moralny. Na czele bractwa stał promotor - funkcja ta należała do miejscowego proboszcza. W przypadku jego nieobecności, ta nadzorcza rola przypadała jego wikariuszowi (zastępcy promotora). Promotor posiadał szereg praw i obowiązków w odniesieniu do bractwa i jego członków. Odpowiedzialność za prawidłowe funkcjonowanie stowarzyszenia dzielił z wybranymi w tym celu braćmi. Członkowie bractwa spotykali się regularnie na mszach i innych nabożeństwach. Nowi członkowie byli przyjmowani podczas ceremonii religijnej zgodnie ze specjalnym rytuałem. Zdecydowanie najwięcej przyjęć miało miejsce 16 maja, w święto św. Jana Nepomucena. Bractwo rekrutowało swoich członków ze wszystkich warstw społecznych w miastach i wsiach całej diecezji. W parafii Krościenko Wyżne lista członków obejmowała zarówno mężczyzn, jak i kobiety, przy czym te ostatnie stanowiły zdecydowaną większość.
Sosialisasi Penerapan Kompor Briket Arang Sekam Padi Pada IKM Penggilingan Gabah di Kab. Gowa
Authors: Dahlan Masbin , Mudriadi Windi , Azis Ismayati Sutisna , Syafaatullah Achmad Qodim
Published: November 2023

Limbah sekam padi yang dihasilkan dari proses penggilingan gabah seringkali menimbulkan masalah lingkungan, karena biasanya hanya dimanfaatkan sebagai pakan ternak, disimpan, atau bahkan dibuang begitu saja. Namun, limbah sekam padi sebenarnya memiliki potensi untuk diubah menjadi bahan bakar yang bermanfaat dan memiliki nilai ekonomis. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan alternatif solusi terhadap permasalahan ini dengan mengkonversi limbah sekam padi menjadi bahan bakar yang dapat digunakan, terutama melalui briket arang sekam padi, dan penggunaan kompor briket. Kegiatan ini ditujukan kepada pemilik, pekerja, dan masyarakat sekitar PT Talasalapang Agro, khususnya di Desa Gangang Baku, Dusun Bilampang Tanah Karaeng, Manuju Kabupaten Gowa. Pendekatan kegiatan ini melibatkan interaksi dengan staf dan karyawan perusahaan serta memberikan pengetahuan tentang cara membuat kompor briket arang beserta briketnya dan manfaat yang dapat diperoleh dari pengelolaan limbah sekam padi ini. Hasil yang diharapkan dari kegiatan ini adalah pemahaman yang lebih baik oleh staf dan karyawan tentang pentingnya penggunaan limbah sekam padi sebagai sumber energi alternatif, serta pemahaman tentang cara penggunaan kompor briket dan pembuatan briket arang dari sekam padi. Mitra dari kegiatan ini berharap agar program ini dapat berlanjut dan berkembang, bahkan menuju pengembangan kompor briket arang dalam skala yang lebih besar.
Pembelajaran Ekoliterasi Untuk Meningkatkan Sikap Empati Peserta Didik Di Sekolah Dasar
Authors: Hilman Irfan , Akmal Rudi , Rahmawati Permana Rima
Published: November 2023

Penelitian ini dilatarbelakangi dengan kurangnya kepedulian peserta didik yang masih kurang terhadap lingkungan. Kurangnya kepekaan peserta didik tentang beberapa permasalahan lingkungan yang muncul di sekitarnya membutuhkan sebuah penerapan pembelajaran ekoliterasi dalam menumbuhkan sikap empati peserta didik terhadap lingkungan, pembelajaran yang mengarahkan peserta didik terhadap perilaku timbal balik yang baik dengan lingkungan. Metode yang dipakai dalam penelitian ini adalah penelitian eksperimen. Penelitian eksperimen merupakan penelitian yang dilakukan dengan melakukan manipulasi.Yang bertujuan untuk mengetahui akibat manipulasi terhadap perilaku individu yang diamati. Manipulasi yang dilakukan dapat berupa situasi atau tindakan tertentu yang diberikan kepada individu atau kelompok dan setelah itu dapat dilihat pengaruhnya. Eksperimen ini dilakukan untuk mengetahui efek yang ditimbulkan dari suatu perlakuan yang diberikan secara sengaja oleh peneliti. Pemberian perlakuan inilah yang menjadi suatu kekhasan penelitian eksperimen dibandingkan dengan penelitian yang lain. Alasan peneliti memilih metode eksperimen karena metode ini dirasa paling cocok untuk meneliti masalah dari penelitian ini. Hasil penelitian ini dinyatakan bahwa penerapan pembelajaran ekoliterasi sangat efektif dalam menumbuhkan sikap empati peserta didik terhadap lingkungan. Selain itu pembelajaran ekoliterasi juga menumbuhkan pengetahuan peserta didik terhadap permasalah lingkungan yang di dapat dari hasil observasi yang menyatakan bahwa 67,78% peserta didik mengetahui permasalahan lingkungan dan solusi alternatif dari permasalahan lingkungan tersebut. Pembelajaran ekoliterasi juga dapat menumbuhkan dan meningkatkan sikap empati peserta didik terhadap lingkungan hal ini dilihat hasil uji N-Gain yang menunjukan angka 0,7 yang artinya bernilai tinggi.Kata kunci: Pembelajaran ekoliterasi, Sikap Empati, Peserta didik SD
Penerapan Media Pembelajaran Big Book Untuk Meningkatkan Kemampuan Membaca Permulaan Pada Pembelajaran Bahasa Indonesia
Authors: Nugraha Fajar
Published: November 2023

Salah satu komponen penting didalam dunia pendidikan adalah membaca. Karena dengan membaca kita dapat menambah wawasan dan pengetahuan mengenai pendidikan yang dapat mendorong terjdinya perubahan yang disertai kemajuan dalam diri individu. Pelajaran Bahasa Indonesia khususnya membaca pada siswa SD perlu diajarkan secara matang Karena pada pelajaran membaca berkaitan dengan bidang studi lainnya. Khususnya membaca permulaan, karena membaca permulaan merupakan fondasi utama siswa dalam mengenal huruf, kata, serta penunjang untuk kemampuan membaca lanjutan. Rendahnya keterampilan membaca siswa di kelas awal harus diatasi agar kedepannya murid tidak mngelami kesulitan dalam pembelajaran, tujuan penelitin ini adalah untuk menerapkan dan  meningkatkan kemampuan membaca permulaan siswa  dengan membaca menggunakan media pembelajaran Big Book. Metode penelitian ini adalah penelitian eksperimen dengan desain penelitian one test group. Subjek penelitian adalah siswa kelas 1 SDIT Al-Ittihaad Cikajang yang berjumlah 26 siswa. Hasil tes kemampuan membaca permulaan siswa pretest adalah sebesar 65,3 rata-rata nilai siswa. Sedangkan pada posttest terjadi peningkatan rata-rata nilai siswa menjadi 90,4 . berdasarkan hasil pengamatan peneili, kemampuan membaca permulaan siswa kelas 1 di SDIT Al-Ittihaad mengalami peningkatan setelah menggunakan media pembelajaran membaca Big Book. Yang artinya media pembelajaran Big Book ini cukup efektif digunakan guru untuk meningkatkan kemampuan membaca permulaan siswa.
Penerapan Model Project Based Learning (PJBL) Untuk Meningkatkan Kemampuan Berpikir Kreatif Pada Pembelajaran Matematika
Authors: Muhamad Nurdin
Published: November 2023

Penelitian ini dilatar belakangi bahwa peringkat Indonesia dalam PISA untuk kemampuan matematika masih berada di peringkat ke-73, hal tersebut masih tergolong sangat rendah. Hal tersebut diperkuat dengan hasil wawancara sebelum penelitan dibeberapa sekolah diwalayah Garut, yang hasilnya bahwa kemampuan matematika rendah dan salah satu cara untuk meningkatkannya melalui peningkatan berfikir kreatif peserta didik, sehingga cara yang perlu dilakukan adalah diminimalisir bahkan ditingkatkan dengan penerapan model Project Based Learning (PJBL). Pada pelaksanaannya tujuan dari penelitian ini adalah untuk melihat bagaimana penerapan, pengaruh, serta mengatahui besarnya peningkatan kemampuan berpikir kreatif setelah diterapkannya model tersebut. Desain yang digunakan dalam penelitian ini adalah Quasi Eksperimen dengan bentuk desain eksperimen ulang (Pretest-Posttest Control Group Design), instrumen yang digunakan dalam penelitian untuk mengambil data berupa lembar observasi, wawancara dan tes kognitif. Hasil dari penelitian ini menyatakan bahwa kemampuan berpikir kreatif setelah diterapkan model Project Based Learning (PJBL) hasil observasi mendapatkan nilai 0,90 dengan kategori sangat baik dialnjutkan dengan uji t untuk pengujian hipotesis, hasilnya bahwa 0,00 < 0,05 atau Ha diterima yang artinya terdapat peningkatan kemampuan berpikir kreatif peserta didik pada pembelajaran matematika menggunakan model project based learning (PJBL). Untuk melihat seberapa tinggi peningkatannya maka dilakukan pengujuan Gain, hasilnya terdapat peningkatan sebesar 0,72 dengan kategori tinggi.
Insights into the Endogenous Opioid System: An Overview
Authors:   Sao Paulo State University, Araraquara, Sao Paulo, Brazil., Pucca Manuela B
Published: November 2023

Pain is a leading cause of medical complaints worldwide, underscoring the essential role of knowledge and use of opioids. Opioids are drugs that directly impact pain processing, immune functions, stress regulation, and more
Del mar a la mesa, panorama de los desafíos del consumo de pescado en Japón
Authors: Matiz Cerón Luisa
Published: November 2023

"Un estudio reciente sobre poblaciones de peces en 110 corrientes entre 1992 y 2019 descubrió que el área de distribución de muchas especies de peces subtropicales y tropicales se ha visto desplazada hacia el norte en las zonas afectadas por las corrientes cálidas, lo que sugiere una posible dispersión de la distribución en el futuro."
Gas Density Within the Pancreas: A Case of Emphysematous Pancreatitis
Authors: Hutsebaut Laurens , Van Snick Elyn , Claikens Bart
Published: November 2023

Teaching Point: Computed tomography is the imaging modality of choice to detect the presence of gas within or around the pancreas in emphysematous pancreatitis.
Therapeutic value of restoration of tumor suppressor microRNAs in the development of lung cancer
Authors: Medina Vico Pedro
Published: November 2023

MicroRNAs (miRNAs) are molecules that regulate gene expression and as such they collaborate to determine how many proteins are produced in the cells of a given gene. As their name indicates, they are functional molecules despite their small size (micro) and are made up of ribonucleic acid (RNA), in contrast to the most extensively studied regulators of gene expression, which are protein in nature. Due to its small size and peculiar nature, the presence of the genes that encode microRNAs was discovered in the human genome in stages after its sequencing, already in the 21st century.
MicroRNAs play a fundamental role in establishing cellular identity and function. Therefore, components of the microRNA synthesis machinery, or microRNAs per se, have been associated with various human pathologies, including cancer.
It has been discovered that microRNAs play an important role in many cellular processes that are altered in cancer such as: differentiation, proliferation, and apoptosis. The genes that code for microRNAs have been found in chromosomal regions frequently gained or lost in cancer. Some microRNAs have altered expression levels in cancer and have demonstrated their ability to affect cellular transformation, carcinogenesis, and metastasis by acting as oncogenes or tumor suppressor genes. Thus, the presence of certain microRNAs has been seen to have clinical diagnostic and prognostic utility and attempts are being made to validate therapies based on the activity of relevant microRNAs in cancer.
The let-7 family of microRNAs was the first discovered in humans. Many of its members are in chromosomal regions frequently deleted in lung cancer tumors. Furthermore, reduced expression of these genes has been correlated with a worse lung cancer prognosis. It is thought that the role of let-7 as a tumor suppressor is due to the fact that it is capable of inhibiting the synthesis of important oncogenes such as RAS, MYC and HMGA2 and that of proteins involved in cell cycle progression such as CDC25A, CDK6 and Cyclin D2. In the present work, experimental results are collected that indicate that the loss of function of let-7 favors tumor development in a mouse tumor model, suggesting the hypothesis that the activity of let-7 collaborates to prevent tumor formation. On the other hand, results are presented that indicate that the reintroduction of let-7 activity in already established lung tumors significantly hinders their growth, even entering regression. These preclinical results demonstrate the antitumor therapeutic potential of let-7 activity and that its reintroduction into lung tumors could have clinical utility if it could be performed efficiently and safely.
A holistic insight into neurodegeneration
Authors: Clerigué Louzado José , Martín-Cámara Olmo
Published: November 2023

Neurodegenerative diseases are defined by a progressive and irreversible impairment of neurons. Despite being a very heterogeneous group of pathologies, they share some common features, such as their multifactorial origin and their close correlation with ageing. As worldwide life expectancy increases, these diseases have become a tough challenge for healthcare systems as their prevalence is raising in the same way. The most important neurodegenerative disorders, because of their prevalence or their health impact, are Alzheimer´s, Parkinson´s and Huntington´s diseases; and amyotrophic lateral sclerosis. The knowledge about their origin is still very poor, so their clinical management is far from being adequate. There are not reliable methods for early diagnosis, so these diseases are usually detected when tissue damage is irreparable. Furthermore, current available therapies are intended only for symptomatic relief, since the misunderstanding about the real causes of these diseases and their delayed diagnosis hinder the development of new treatments being able to stop or even reverse the structural and functional decline.
In the last few years, some pathological events have been identified as potential key factors to understand the origin of neurodegeneration. Among them, we shall mention oxidative stress, impaired proteostasis and neuroinflammation: a deeper knowledge about their interconnections and their ability to feedback each other could provide valuable information to progress towards an effective clinical management of neurodegenerative disorders.
After-action reviews for emergency preparedness and response to infectious disease outbreaks
Authors: Quach Ha-Linh , Nguyen Khanh Cong , Vogt Florian
Published: November 2023

After-action reviews (AARs) are a qualitative evaluation methodology conducted after a public health event recommended by the World Health Organization. Of 86 screened articles, we identified eight using AARs to evaluate public health responses to infectious disease outbreaks. Our findings suggested the toolkit is suitable to evaluate responses to infectious disease outbreaks but needs to be adapted for use in particular settings.