bluuebunny/crossref_metadata_2025 huggingface dataset:
Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition
Authors: Lang Jessica D. , Hendricks William P. D. , Yin Holly , Kiefer Jeffrey , Ramos Pilar , Sharma Ritin , Pirrotte Patrick , Raupach Elizabeth A. , Sereduk Chris , Tang Nanyun , Liang Winnie , Washington Megan , Facista Salvatore J. , Zismann Victoria L. , Cousins Emily M. , Major Michael B. , Wang Yemin , Karnezis Anthony N. , Orlando Krystal A. , Sekulic Aleksandar , Hass Ralf , Vanderhyden Barbara , Praveen Kesavannair , Weissman Bernard E. , Huntsman David G. , Trent Jeffrey M.
Published: July 2017

Structured Abstract

Purpose: Subunits of the SWI/SNF chromatin-remodeling complex are tumor suppressors inactivated in ∼20% of all cancers. Yet, few targeted treatments for SWI/SNF-mutant cancers exist. Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive ovarian cancer in young women that is universally driven by loss of the SWI/SNF ATPase subunits, SMARCA4 and SMARCA2. Given poor two-year survival rates for these women, a great need exists for effective targeted therapies.

Experimental Design: To identify underlying therapeutic vulnerabilities in SCCOHT, we conducted high-throughput siRNA and drug screens. Complementary proteomics approaches comprehensively profiled kinases inhibited by ponatinib. Ponatinib was tested for efficacy in two PDX models and one cell line xenograft model of SCCOHT.

Results: FGFRs and PDGFRs were overlapping hits between screens and the receptor tyrosine kinase (RTK) family was enriched in the siRNA screen hits. Evaluation of eleven RTK inhibitors in three SCCOHT cell lines identified ponatinib, an inhibitor of multiple RTKs, as the most effective clinically approved agent. Proteomics approaches confirmed inhibition of known targets of ponatinib and more than 20 non-canonical ponatinib targets. Ponatinib also delayed tumor doubling time 4-fold in SCCOHT-1 xenografts and reducing final tumor volumes in two SCCOHT patient-derived xenograft (PDX) models by 58.6% and 42.5%.

Conclusion: Ponatinib is an effective agent for SCCOHT in bothin vitroandin vivopreclinical models through its inhibition of multiple kinases. Clinical investigation of this FDA-approved oncology drug in SCCOHT is warranted.

Additional Information

This work was supported by research funds from the Canadian Cancer Society Research Institute 34 (#703458, D.G.H.), the National Institutes of Health (R01 CA195670-01, B.E.W., D.G.H., and 35 J.M.T., and T32 HL007106-39 to E.M.C), the Terry Fox Research Institute Initiative New Frontiers Program in Cancer (#1021, D.G.H.), the British Columbia Cancer Foundation (D.G.H.), the VGH & UBC Foundation (D.G.H.), the Anne Rita Monahan Foundation (P.R.), the Marsha Rivkin Center for Ovarian Cancer Research (J.M.T.), the Ovarian Cancer Alliance of Arizona (J.M.T.), the Small Cell Ovarian Cancer Foundation (P.R., J.D.L., B.V., and J.M.T.), and philanthropic support to the TGen Foundation (J.M.T.).

COI disclosure statement: The authors declare no potential conflicts of interest.
Iron-dependent essential genes inSalmonellaTyphimurium
Authors: Karash Sardar , Kwon Young Min
Published: July 2017

Background

The molecular mechanisms underlying bacterial cell death due to stresses or bactericidal antibiotics are complex and remain puzzling. Previously, it was shown that iron is required for effective killing of bacterial cells by numerous bactericidal antibiotics. Here, our high-resolution Tn-seq analysis demonstrated that transposon mutants ofS.Typhimurium with insertions in essential genes escaped immediate killing or growth inhibition under iron-restricted conditions for approximately one-third of all essential genes.

Results

We grouped essential genes into two categories, iron-dependent and iron-independent essential genes. The iron-dependency of the iron-dependent essential genes was further validated by the fact that the relative abundance of these essential gene mutants increased further with more severe iron restrictions. Our unexpected observation can be explained well by the recently proposed common killing mechanisms of bactericidal antibiotics via production of reactive oxygen species (ROS). In this model iron restriction would inhibit production of ROS, leading to reduced killing activity following blocking of an essential function. Interestingly, the targets of most antibiotics currently in use clinically, whether bacteriostatic or bactericidal, are iron-dependent essential genes.

Conclusions

Our result suggests that targeting iron-independent essential genes may be a better strategy for future antibiotic development, because blocking these genes would lead to immediate cell death regardless of iron concentration. On the contrary, blocking iron-dependent pathways under iron limitedin vivoenvironment could lead to reduced killing action, which might increase drug-resistance by mutagenic action of sublethal concentrations of ROS. This work expands our knowledge on the role of iron to a broader range of essential pathways, and provides novel insights for development of more effective antibiotics.
Metabolic process of raffinose family oligosacharrides during cold stress and recovery in cucumber leaves
Authors: Lu Man , Zhang Zhiping , Xu Jinjin , Cao Wenhua , Miao Minmin
Published: July 2017

Raffinose family oligosacharrides (RFOs) accumulate under stress conditions in many plants and have been suggested to act as stress protectants. To elucidate the metabolic process of RFOs under cold stress, levels of RFOs and relative carbohydrates, the expression and activities of main metabolic enzymes and their subcellular compartments were investigated during low temperature treatment and recovery period in cucumber leaves. Cold stress induced the accumulation of stachyose in vacuoles, galactinol in vacuoles and cytosols, and sucrose and raffinose in vacuoles, cytosols and chloroplasts. After cold stress removal, levels of these sugars decreased gradually in respective compartments. Among 4 galactinol synthase genes (CsGS),CsGS1was not affected by the cold stress, while other threeCsGSswere up-regulated by the low temperature. RNA levels ofacid-α-galactosidase (GAL) 3, alkaline-α-galactosidase (AGA) 2and3, and the activities of GAL and AGA were up-regulated after cold stress removal. The GAL3 protein and GAL activity were exclusively located in the vacuole, whereas the protein of AGA2 and AGA 3 were found in the cytosol and chloroplast respectively. The results indicate that RFOs accumulated during the cold stress in different subcellular compartments in cucumber leaves could be catabolizedin situby different galactosidases after stress removal.
In vivocalcium imaging visualizes peripheral neuron sensitization in murine osteoarthritis
Authors: Miller Rachel E. , Kim Yu Shin , Tran Phuong B. , Dong Xinzhong , Miller Richard J. , Malfait Anne-Marie
Published: July 2017

Objective

The purpose of this study was to develop a method for analyzing sensory neuron responses to mechanical stimuliin vivo, and to evaluate whether these neuronal responses change after destabilization of the medial meniscus (DMM).

Methods

DMM or sham surgery was performed in 10-week old male C57BL/6 wild-type or Pirt-GCaMP3+/−mice. All experiments were performed eight weeks after surgery. Knee and hind paw hyperalgesia were assessed in wild-type mice. The retrograde label DiI was injected into the ipsilateral knee to quantify the number of knee-innervating neurons in the L4 dorsal root ganglion (DRG) in wild-type mice.In vivocalcium imaging was performed on the ipsilateral L4 DRG of Pirt-GCaMP3+/−mice as mechanical stimuli (paw pinch, knee pinch, knee twist) were applied to the ipsilateral hind limb.

Results

Eight weeks after surgery, DMM mice had more hyperalgesia in the knee and hind paw compared to sham mice. Intra-articular injection of DiI labeled similar numbers of neurons in the L4 DRG of sham and DMM mice. Increased numbers of sensory neurons responded to all three mechanical stimuli in DMM mice, as assessed byin vivocalcium imaging. The majority of responses in sham and DMM mice were in small-to-medium-sized neurons, consistent with the size of nociceptors. The magnitude of responses was similar between sham and DMM mice.

Conclusions

We demonstrated that increased numbers of small-to-medium sized DRG neurons respond to mechanical stimuli 8 weeks after DMM surgery, suggesting that nociceptors have become sensitized by lowering the response threshold.
Trans-splicing enhances translational efficiency in C. elegans
Authors: Yang Yu-Fei , Zhang Xiaoqing , Ma Xuehua , Zhao Taolan , Sun Qiushi , Huan Qing , Wu Shaohuan , Du Zhuo , Qian Wenfeng
Published: July 2017

Translational efficiency is subject to extensive regulation. However, the factors influencing such regulation are poorly understood. In Caenorhabditis elegans, 62% of genes are trans-spliced to a specific spliced leader (SL1), which replaces part of the native 5′ untranslated region (5′ UTR). Given the pivotal role the 5′ UTR plays in the regulation of translational efficiency, we hypothesized that SL1 trans-splicing functions to regulate translational efficiency. With genome-wide analysis on Ribo-seq data, polysome profiling experiments, and CRISPR-Cas9–based genetic manipulation of trans-splicing sites, we found four lines of evidence in support of this hypothesis. First, SL1 trans-spliced genes have higher translational efficiencies than non-trans-spliced genes. Second, SL1 trans-spliced genes have higher translational efficiencies than non-trans-spliced orthologous genes in other nematode species. Third, an SL1 trans-spliced isoform has higher translational efficiency than the non-trans-spliced isoform of the same gene. Fourth, deletion of trans-splicing sites of endogenous genes leads to reduced translational efficiency. Importantly, we demonstrated that SL1 trans-splicing plays a key role in enhancing translational efficiencies of essential genes. We further discovered that SL1 trans-splicing likely enhances translational efficiency by shortening the native 5′ UTRs, hence reducing the presence of upstream start codons (uAUG) and weakening mRNA secondary structures. Taken together, our study elucidates the global function of trans-splicing in enhancing translational efficiency in nematodes, paving the way for further understanding the genomic mechanisms of translational regulation.
Fixed-time compliant motion/force control of robotic manipulators with environmental constraints
Authors: Ma Chao
Published: July 2017

Purpose

The purpose of this paper is to design a new compliant motion/force control strategy for robotic manipulators with environmental constraints in the sense of fixed-time stability.

Design/methodology/approach

This paper investigates a novel compliant motion/force control strategy for robotic manipulators with environmental constraints. By using the Lyapunov theory and fixed-time stability theory, a non-singular terminal sliding mode manifold is first established. Then, the compliant motion/force controller is designed, and relevant conditions are given for guaranteeing that the robotic manipulator can track the prescribed constrained trajectory while exerting a desired force to the environment in fixed-time. An illustrative example is presented to show the effectiveness of our proposed control strategy.

Findings

Based on fixed-time stability theory, the desired compliant motion/force controller for robotic manipulators with environmental constraints is developed.

Originality/value

Compared with most existing literature, the proposed fixed-time compliant motion/force control strategy can provide the upper bound of the settling time independent of the initial conditions in designing procedure and is more practical for the real-world applications.
Development of a novel paediatric surgical assist robot for tissue manipulation in a narrow workspace
Authors: Liu Quanquan , Shi Chaoyang , Zhang Bo , Wang Chunbao , Duan Lihong , Sun Tongyang , Zhang Xin , Li Weiguang , Wu Zhengzhi , Fujie Masakatsu G.
Published: July 2017

Purpose

Paediatric congenital esophageal atresia surgery typically requires delicate and dexterous operations in a narrow and confined workspace. This study aims to develop a novel robot assisted surgical system to address these challenges.

Design/methodology/approach

The proposed surgical robot consists of two symmetrical slave arms with nine degree of freedoms each. Each slave arm uses a rigid-dexterous configuration and consists of a coarse positioning manipulator and a distal fine operation manipulator. A small Selective Compliance Assembly Robot Arm (SCARA) mechanism was designed to form the main component of the coarse positioning unit, ensuring to endure large forces along the vertical direction and meet the operational demands. The fine positioning manipulator applied the novel design using flexible shafts and universal joints to achieve delicate operations while possessing a high rigidity. The corresponding kinematics has been derived and then was validated by a co-simulation that was performed based on the combined use of Adams and MATLAB with considering the real robot mass information. Experimental evaluations for the tip positioning accuracy and the ring transfer tasks have been performed.

Findings

The simulation was performed to verify the correctness of the derived inverse kinematics and demonstrated the robot’s flexibility. The experimental results illustrated that the end-effector can achieve a positioning accuracy within 1.5 mm in a confined 30 × 30 × 30 mm workspace. The ring transfer task demonstrated that the surgical robot is capable of providing a solution for dexterous tissue intervention in a narrow workspace for paediatric surgery.

Originality/value

A novel and compact surgical assist robot is developed to support delicate operations by using the dexterous slave arm. The slave arm consists of a SCARA mechanism to avoid experiencing overload in the vertical direction and a tool manipulator driven by flexible shafts and universal joints to provide high dexterity for operating in a narrow workspace.
Accounting, auditing and accountability research in Africa
Authors: Nyamori Robert Ochoki , Abdul-Rahaman Abu Shiraz , Samkin Grant
Published: July 2017

Purpose

The purpose of this paper is to discuss developments in governance in Africa and the opportunities this offers to accounting, auditing and accountability researchers. The paper also provides an overview of the other contributions in this accounting, auditing and accountability special issue.

Design/methodology/approach

This paper provides a contemporary literature review on governance and accountability in Africa, identifying the key developments in public sector reform and the research gaps that still need to be filled. While the paper focuses on Sub-Saharan Africa, the authors draw on examples from Ghana, Kenya, and South Africa – geographically representing east, west, and south of the continent.

Findings

The paper finds that governance has emerged as a crucial issue that has a significant effect on the economic development of African countries. This has been associated with a myriad of reforms which range from anti-corruption measures to public financial management reforms. The authors find that the implementation and effects of these reforms have not been adequately researched by accounting scholars.

Research limitations/implications

This is a review of a limited literature. Empirical research and a more comprehensive review of the literature from public administration and other disciplines might provide other new insights for research on governance in Africa. A further limitation is that the study has focused on a review of the most recent reforms while earlier reforms should be of particular interest to accounting historians.

Originality/value

This paper and other contributions to this special issue ofAAAJprovide a basis and an agenda for accounting scholars seeking to undertake interdisciplinary research on Africa.
Moderators of telework effects on the work-family conflict and on worker performance
Authors: Solís Martín
Published: July 2017

Purpose

The relations telework-work interference with the family (WIF), telework-family interference with work (FIW), and telework-performance have been widely studied; however, results of different investigations are contradictory. This may be related to third variables that moderate the effect of relations. The purpose of this paper is to analyze the moderating effect of worker responsibilities outside of the work environment on telework-FIW and telework-WIF relations, as well as the moderating effect of control by the supervisor on teleworkers in the telework-performance relation.

Design/methodology/approach

A total of 92 teleworkers were interviewed, and 72 non-teleworkers who work in four public institutions. Non-teleworkers work in the same departments as teleworkers, and carry out similar functions. In addition, 33 supervisors were interviewed who evaluated performance of both groups. Hierarchical lineal regression analysis models were used to evaluate the influence of telework on the dependent variables.

Findings

The results obtained reveal that where there are low-responsibility levels, teleworkers present a lower FIW than non-teleworkers; however, with high levels of responsibility, teleworkers show higher FIW. Additionally, supervisors’ control of teleworkers was found to have a negative effect on their pro-activity and adaptability to tasks.

Originality/value

The findings provide new empirical evidence about the effect of moderating variables in the relation between telework-work-family conflict and telework-performance. Besides the results provide practical and useful implications to organizations that implement telework programs.
Parametric study and performance improvement of regenerative flow pump considering the modification in blade and casing geometry
Authors: Nejad Jafar , Riasi Alireza , Nourbakhsh Ahmad
Published: July 2017

Purpose

Regenerative flow pump (RFP) is a rotodynamic turbomachine capable of developing high pressure rise at low flow rates. This paper aims to numerically investigate the performance of a regenerative pump considering the modification in blade and casing geometry.

Design/methodology/approach

The radial blade shape was changed to the bucket form and a core is added to flow path. A parametric study was performed to improve the performance of the pump. Thus, the effect of change in blade angle, chord, height, pitch to chord ratio and also inlet port on the performance of RFP was investigated.

Findings

Results showed that the modified blade angle to achieve the maximum efficiency is about 41 degree. Also, the most efficient point occurs close to pitch/chord = 0.4 and by reducing the axial chord, efficiency of the pump increases. It was found that better efficiency will be achieved by increasing the “Arc of admission”, but there are limitations of manufacturing. It was observed that the performance curves shifted towards lower flow coefficients by reducing height of blades.

Originality/value

To improve the characteristics of regenerative pump, the blade shape changed to the bucket form (airfoil blades with identical inlet and outlet angle) and a core is added to flow path. A parametric study has been accomplished to see the influence of some important parameters on the performance of the pump.
Information and involvement: the influence on the acceptance of innovative wine packaging
Authors: Nesselhauf Lucas , Deker Johannes S. , Fleuchaus Ruth
Published: July 2017

Purpose

The purpose of this paper is to show that consumer education in the form of information can effectively overcome adoption barriers to new and innovative wine packaging. This effectiveness depends on both the degree in packaging innovation and the level of consumer involvement.

Design/methodology/approach

The paper is based on an online experiment conducted with a sample of 427 German consumers to analyse the perception of consumers about innovative packaging. The experiment featured three different packaging options: bottles with screw-cap closures, bag-in-box and StackTek®. For each packaging form, a treatment group with additional information about the packaging and a reference group without this information were surveyed. ANOVA and t-tests were carried out to test the hypotheses. A moderated regression analysis was used to examine the effect of involvement in combination with information on intention to buy.

Findings

The results revealed that low-involvement consumers react positively to additional information about the benefits of a new packaging. For highly involved consumers, however, the effect of information is not significant. Furthermore, the analysis showed that low-involvement consumers mainly buy wine in supermarkets.

Practical implications

Information about new packaging forms should be presented in places where low-involvement consumers buy wine, such as at supermarkets. These consumers can be influenced by the additional information about the innovative packaging.

Originality/value

The use of a moderated regression analysis in the context of wine packaging and involvement is a first and reveals new and valuable insights.
Macroeconomic determinants of wine prices
Authors: Jiao Linda
Published: July 2017

Purpose

The purpose of this paper is to identify the macroeconomic determinants of fine-wine prices and estimate their impacts.

Design/methodology/approach

The author models the Liv-ex fine-wine price indices with the macroeconomic variables of emerging and developed markets on a monthly basis from 1996 to 2015.

Findings

The demand from emerging markets plays a key role in fine-wine pricing and, more precisely, in the price fluctuation of prestige Bordeaux wines. Furthermore, the continuous weakening of the US dollar in real terms favors an increase in fine-wine prices. Since 2011, the slowdown in economic growth in emerging markets, followed by the depreciation of national currencies, has negatively affected the luxury wine market. Along with the process of financialization in the fine-wine market, prices have become more volatile. Factors such as money supply, real interest rates and the growth of investment funds have started to show their influence on fine-wine pricing.

Originality/value

Complementary to the hedonic price modeling, this research can provide an analysis to wine-price modeling and forecasting within the macroeconomic approach.
Do women perform better in family firms?
Authors: D’Amato Antonio
Published: July 2017

Purpose

Empirical evidence on the relation between female involvement at the head of a company and firm performance remains inconclusive. This study aims to disentangle the existing evidence by exploring the moderating role of family firm status.

Design/methodology/approach

The study analyzes the moderating role of family firm status on the relation between gender diversity and firm performance among a sample of 88 Italian wine firms from Campania region during the 2007-2014 period. This work uses random effects panel data regression and tests the robustness of the results using alternative econometric techniques. Performance is measured in terms of profitability.

Findings

The findings reveal that women in top positions do not affect firm performance. However, it is found that this relation is significantly moderated by family firm status. Specifically, compared to high family-controlled firms, female involvement negatively impacts firm performance in low family-controlled firms.

Research limitations/implications

From a theoretical standpoint, the results enable a more nuanced interpretation of the relationship between female involvement and firm performance. From a managerial perspective, the results highlight conditions that may promote the role of women in business.

Originality/value

This paper provides insights into the relation between gender diversity and firm performance by exploring the moderating role of family firm status – a novel approach in the management and wine business literature.
The Global Compact and its concrete effects
Authors: Coulmont Michel , Berthelot Sylvie , Paul Marc-Antoine
Published: July 2017

Purpose

The purpose of this study is to document the concrete practices put in place by United Nations Global Compact (UNGC) affiliated firms and their application of the UNGC Communication on Progress (COP).

Design/methodology/approach

The paper examines the practices implemented by firms on the Fortune 500 list that have affiliated with the UNGC and issued a COP separate from their annual report or a sustainable development report. According to the UNGC, the COP policy sets out a description of practical actions the company has taken or plans to take to implement the ten principles.

Findings

The findings tend to show that firms affiliated with the UNGC use a variety of practices to integrate these principles. Many adopt policies based on an international standard relating to a UNGC principle. However, the reporting process supported by the UNGC does not seem to fully promote the widespread application of these practices.

Originality/value

The documentation of these practices will serve as a reference for any business interested in adopting the UNGC principles or for government and non-government organisations, including accounting standard setters, aiming to promote and support the universal principles on human rights, labour, the environment and anti-corruption. In addition, the study reveals weaknesses in the UNGC COP policy that could limit more extensive application of these practices.
Numerical modeling of structural frames with infills subjected to thermal exposure
Authors: Kumar Puneet , Srivastava Gaurav
Published: July 2017

Purpose

Reinforced concrete structural frames with masonry infills (infill-frames) are commonly used for construction worldwide. While the behavior of such frames has been studied extensively in the context of earthquake loading, studies related to their fire performance are limited. Therefore, this study aims to characterize the behavior of infill-frames under fire exposure by presenting a state-of-the-art literature review of the same.

Design/methodology/approach

Both experimental and computational studies have been included with a special emphasis on numerical modeling (simplified as well as advanced). The cold behavior of the infill-frame and its design requirements in case of fire exposure are first reviewed to set the context. Subsequently, the applicability of numerical modeling strategies developed for modeling cold infill-frames to simulate their behavior under fire is critically examined.

Findings

The major hurdles in developing generic numerical models for analyzing thermo-mechanical behavior of infill-frames are identified as: lack of temperature-dependent material properties, scarcity of experimental studies for validation and idealizations in coupling between thermal and structural analysis.

Originality value

This study presents one of the most popular research problems connected with practical and reliable utilization of numerical models, as a good alternative to expensive traditional furnace testing, in assessing fire resistance of infill-frames. It highlights major challenges in thermo-mechanical modeling of infill-frames and critically reviews the available approaches for modeling infill-frames subjected to fire.
The core processes adopted for outsourcing HRM in Australia and its outcomes
Authors: Susomrith Pattanee , Brown Alan
Published: July 2017

Purpose

The purpose of this paper is to discover the types of HR outsourcing processes employed by Australian organisations and their relationship to outsourcing outcomes.

Design/methodology/approach

This paper is based upon the results of a survey of medium to large Australian organisations. The survey data were analysed using quantitative analysis to extract the types of HR outsourcing processes, outcomes, and their relationship.

Findings

The analyses identified three types of HR outsourcing processes: screening and selecting, strategic fit, and managing and monitoring. The “strategic fit” process exhibited the strongest relationship to the HR outsourcing outcome followed by the “managing and monitoring” process. The “screening and selecting” did not correlate with HR outsourcing outcome. For each type of HR outsourcing process no correlation was found with the outsourced HR functions. It was found that the most important criteria for selecting an outsourced service provider were trustworthiness, reputation in the industry, cost structure, and history with the organisation. The least important criteria were the service provider’s financial position and cultural similarity with the organisation.

Research limitations/implications

The research design acquired information from a single participant from each organisation which may result in a one-dimensional view. In addition, the data were collected from Australian organisations limiting its generalisation globally. Environmental and political factors were not included in the study. Therefore, researchers are encouraged to consider the influence of these factors on the HR outsourcing process.

Practical implications

The discovered HR outsourcing processes, although different from the generic HR outsourcing model, can be used by organisations to outsource HR functions in a more efficient and effective manner within the Australian context. The research results also indicate the importance for service providers to develop a good reputation and establish trust.

Originality/value

This study is the first quantitative research that determines the specific HR outsourcing processes and how they related to the HR outsourcing outcome in medium to large Australian organisations. The identification of these process types is unique and useful in validating and refining HR outsourcing knowledge within the Australian context.
A comparative study of entrepreneurship education between Singapore and Taiwan
Authors: Yu Min-Chun , Goh Mark , Kao Hao-Yun , Wu Wen-Hsiung
Published: July 2017

Purpose

For entrepreneurship education issue, the purpose of this paper is to apply a novel four-step method of comparative education research and assessment items for university-based entrepreneurship ecosystems (U-BEEs), with a specific focus on universities in Taiwan and Singapore. In this paper, entrepreneurship education development is explored, and important implications for the further improvement of entrepreneurship education are provided.

Design/methodology/approach

This study is based on the comparative education research method and proceeds in four steps (i.e. description, interpretation, juxtaposition, and comparison). The U-BEE items are applied to exemplify the similarities and differences of the process by which entrepreneurship education developed in two universities each in Singapore (National University of Singapore and Nanyang Technological University) and Taiwan (National Taiwan University and National Tsing Hua University).

Findings

From the country-based standpoint, the findings include considering broader factors (i.e. history, education) in such a comparison of the similarities and differences among four universities, reflecting the reality in the Asian region and introducing the method application of comparative education research for the first time in entrepreneurship education. From holistic and specific perspectives of U-BEE, the findings consist of presenting similarities and differences based on the comparisons of each item and showing the classified findings.

Originality/value

This study provides helpful insights based on the perspectives of academics and practitioners. First, the authors urge the necessity of the theoretical base of teaching and learning in education when universities plan for entrepreneurship education. Second, the authors stress the critical impact of the government on the execution of entrepreneurship education in the higher education context.
How can European museums reach sustainability?
Authors: Recuero Virto Nuria , Blasco López Maria Francisca , San-Martín Sonia
Published: July 2017

Purpose

This research aims to provide evidence of the impacts of market orientation, customer value approach (through prestige, value for money and reputation for quality) and innovation on museum sustainability.

Design/methodology/approach

The model is analysed through partial least squares (PLS-SEM), using a sample of 549 European museums.

Findings

The results reveal that reputation for quality, prestige, innovation and value for money positively and significantly influence museum sustainability. Interestingly, the most meaningful linkage is between market orientation and innovation.

Practical implications

This research helps museums that need to increase their customer value and innovativeness so as to ensure museum sustainability. It proves that museum managers have to increase employees’ involvement in decision-making processes.

Originality/value

By using a wide sample of European museums, this study suggests that museum managers need to consider the impact of marketing strategies and customer value perceptions on the economic and social sustainability of museums.
At home away or arrived in Spain: translocalism and neighbourhood social circles among long-term visitors in Costa Blanca leisurescapes
Authors: Jacobsen Jens Kr. Steen , Nogués-Pedregal Antonio Miguel
Published: July 2017

Purpose

The purpose of this paper is to outline and interpret social circles and networks of long-term visitors to Costa Blanca (Spain) and to analyse how the long-termers relate to Spanish nationals and compatriots in their (temporary) residence areas.

Design/methodology/approach

En route airport questionnaire survey to departing passengers.

Findings

The study indicates a presence of translocalism among many of the polyglot long-termers not tied to their native soil and having manifold links across national borders. Most of them socialise within compatriot leisurescape settings. Language skills are determinant. Many long-termers are “dual citizens”, feeling at home both here and there.

Research limitations/implications

Airport surveys can reach a broad range of people but must be kept simple because of time constraints. The different labels used by researchers to describe international mobility might not be comprehensive.

Practical implications

The paper is of interest to local authorities, planners, property developers and tourism destination service providers.

Social implications

The study confirms that some persons may be physically “in” a foreign culture while socially “outside” of that culture, or in society but not of it.

Originality/value

The research uniquely encompasses all types of long-termers in various locations, based on an airport survey. It offers new insights into patterns of social circles and language proficiencies of diverse international long-term arrivals in Mediterranean Spain.
How do department high‐performance work systems affect creative performance? a cross‐level approach
Authors: He Changqing , Gu Jibao , Liu Hefu
Published: July 2017

In this study, we examine the relationship between department high‐performance work systems (DHPWS) and employees’ creative performance. Data are obtained from a sample of 335 employees in 74 departments in People's Republic of China. Results of hierarchical linear modeling reveal that DHPWS are positively related to employees’ creative performance, and organizational citizenship behavior (OCB) partially mediates that relationship. Perspective taking, which represents a cognitive factor in which employees focus on others and adopt others’ viewpoint in order to better understand their preferences and values, moderates the DHPWS–OCB relationship. However, perspective taking does not serve as a moderator between DHPWS and employees’ creative performance. These findings shed new light on the mechanisms through which DHPWS influence employees’ creative performance and contribute to the strategic HRM and creativity literature. We discuss implications of these results for research and practice.
STRESS, GENES, AND GENERALIZABILITY ACROSS GENDER: EFFECTS OF MAOA AND STRESS SENSITIVITY ON CRIME AND DELINQUENCY*
Authors: WELLS JESSICA , ARMSTRONG TODD , BOISVERT DANIELLE , LEWIS RICHARD , GANGITANO DAVID , HUGHES‐STAMM SHEREE
Published: July 2017

In the current study, we extend the gene‐by‐environment interaction (cGxE) literature by examining how a widely studied polymorphism, the MAOA upstream variable number tandem repeat (MAOA‐uVNTR) interacts with distal and proximal stressors to explain variation in crime and delinquency. Prior research findings have revealed that MAOA‐uVNTR interacts with single indicators of environmental adversity to explain criminal behavior in general‐population and incarcerated samples. Nevertheless, the genetically moderated stress sensitivity hypothesis suggests that increased risk for criminal behavior associated with variation in the MAOA‐uVNTR can be best understood in the context of both distal stress during childhood and proximal stress in adulthood. Therefore, we employed Tobit regression analyses to examine a gene–distal–proximal environment (CGxExE) interaction across gender in a sample of university students (n = 267) and with data from the National Longitudinal Study of Adolescent to Adult Health (Add Health; n = 1,294). The results across both sets of analyses demonstrate that variation in the MAOA‐uVNTR interacts with distal and proximal stress to lead to increased risk for criminal behavior in males. Although proximal life stress is associated with an increase in crime and delinquency, this effect is more pronounced among MAOA‐L allele carriers that have experienced distal stress.
Comparison of gastrointestinal parasite communities in vervet monkeys
Authors: VALENTA Kim , TWINOMUGISHA Dennis , GODFREY Kathleen , LIU Cynthia , SCHOOF Valérie A. M. , GOLDBERG Tony L. , CHAPMAN Colin A.
Published: July 2017

Globally, habitat degradation is accelerating, especially in the tropics. Changes to interface habitats can increase environmental overlap among nonhuman primates, people, and domestic animals and change stress levels in wildlife, leading to changes in their risk of parasite infections. However, the direction and consequences of these changes are unclear, since animals may benefit by exploiting human resources (e.g., improving nutritional health by eating nutritious crops) and decreasing susceptibility to infection, or interactions with humans may lead to chronic stress and increased susceptibility to infection. Vervet monkeys are an excellent model to understand parasitic disease transmission because of their tolerance to anthropogenic disturbance. Here we quantify the gastrointestinal parasites of a group of vervet monkeys (Chlorocebus aethiops) near Lake Nabugabo, Uganda, that frequently overlaps with people in their use of a highly modified environment. We compare the parasites found in this population to seven other sites where vervet monkey gastrointestinal parasites have been identified. The vervets of Lake Nabugabo have the greatest richness of parasites documented to date. We discuss how this may reflect differences in sampling intensity or differences in the types of habitat where vervet parasites have been sampled.
Prevalence of and risk factors for diabetic ketosis in Chinese diabetic patients with random blood glucose levels >13.9 mmol/L: Results from the CHina study in prEvalence of diabetiC Ketosis (CHECK) study
Authors: Gao Leili , Li Yufeng , Fei Dadong , Ma Li , Chen Shuchun , Feng Bo , Su Qing , Ji Linong
Published: July 2017

Background

The aim of the present study was to investigate the prevalence of diabetic ketosis (DK) and its risk factors in Chinese diabetes patients with severe hyperglycemia.

Methods

The present multicenter cross‐sectional study was performed on patients aged >16 years with diabetes mellitus (DM) and random blood glucose levels >13.9 mmol/L (>250 mg/dL). Blood ketones (β‐hydroxybutyric acid) and urinary ketones (acetoacetic acid) were measured and information on patient demographic and clinical characteristics was collected.

Results

Of 1235 patients enrolled in the study (93 with type 1 DM [T1DM]), 1142 with type 2 DM [T2DM]), 242 (19.6%) had DK (blood ketone levels ≥0.6 mmol/L). Proportionately, DK was more frequent and more severe in patients with T1DM than T2DM (55.9% vs 16.6%, respectively), but in absolute terms occurred in more patients with T2DM (52 vs 190). In patients with blood ketone levels ≥3 mmol/L, the cut‐off point of blood glucose levels was 19.05 mmol/L. Risk factors significantly associated with higher blood ketone levels in T2DM included younger age, a shorter duration of diabetes, and not using antidiabetic medication within 12 months prior to the hyperglycemic episode.

Conclusions

The prevalence of DK is lower in patients with T2DM than T1DM, but the number of patients with DK is higher for those with T2DM because of more T2DM patients in China. Patients with T2DM who have a younger age, shorter duration of diabetes, and a lack of antidiabetic treatment will suffer from DK more often than older patients with longer T2DM duration and receiving antidiabetic treatment.
Substrates across horticultural and livestock industries that support the development of stable fly, Stomoxys calcitrans (Diptera: Muscidae)
Authors: Cook David F , Telfer Don V , Lindsey Jeremy B , Deyl Robert A
Published: July 2017

This study examined a multitude of potential substrates across horticultural and livestock industries that supported the development of the stable fly, Stomoxys calcitrans (Linneaus) (1081 samples from over 100 properties (2010–2016)). Stable fly developed in high numbers from vegetable crop residues left after harvest, notably celery and leeks as well as several brassica crops, lettuce and silverbeet. Unmarketable vegetables (reject produce) and processing waste provided another source of stable fly development, in particular from carrot production (green tops and processing washings) as well as beetroot and daikon leaves, reject zucchinis, rockmelons, eggplants, turnips and squashes. Reject produce from mostly solanaceous plants either did not support any or rarely supported the development of adult stable fly. Reject vegetable produce fed to livestock presented a source for stable fly to develop in the vegetable/manure mix, especially from carrots and corn cobs. Large accumulations of cattle dung in feedlot situations, hay feeding out sites, wet grain feed and exposed silage produced the highest numbers of stable fly from livestock industries. Cattle dung from rangeland pastures, pig manure and horse manure rarely if ever supported the development of stable fly. Only cattle dung that had aged or pig manure that had been mixed with straw and left to age allowed for any stable fly development. Miscellaneous sources of stable fly development include rotting lawn clippings, rotting weeds, ageing olive pressing residue, and to a lesser extent, rotting wild melons and seaweed.
Time course study of Bactrocera oleae (Diptera: Tephritidae) pupae predation in soil: the effect of landscape structure and soil condition
Authors: Ortega Marta , Sánchez‐Ramos Ismael , González‐Núñez Manuel , Pascual Susana
Published: July 2017

Environmentally friendly control measures are necessary for the olive fruit fly Bactrocera oleae (Rossi). Predation of pupae in soil should be better understood because it contributes to the natural control of pest populations.

A time course field trial was carried out in 2015 and 2016 in 15 olive orchards selected to represent a gradient of landscape complexity. Exclusion cages were used to estimate predation rate. A combination of tillage intensity and soil coverage by herbaceous vegetation, hereafter referred to as soil condition, was also assessed as a factor affecting predation rate. The viability of the pupae recovered from the field was also evaluated.

Predation was higher in the autumn than in late winter–early spring, although predation rate values were generally quite low.

Landscape structure affected predation. In the autumn, the area of Mediterranean scrublands promoted predation in the olive groves. In late winter–early spring, weak tendencies were registered.

Soil condition affected predation in autumn as well. The intense tillage and poor soil coverage were related to lower values of predation rate.

To favour conservation biological control of B. oleae by pupae predation, it is advisable to reduce the intensity of soil management, especially in autumn, and to preserve areas of scrublands surrounding the olive groves.
Cerebrocortical activity during self‐paced exercise in temperate, hot and hypoxic conditions
Authors: Périard J. D. , De Pauw K. , Zanow F. , Racinais S.
Published: July 2017

Aim

Heat stress and hypoxia independently influence cerebrocortical activity and impair prolonged exercise performance. This study examined the relationship between electroencephalography (EEG) activity and self‐paced exercise performance in control (CON, 18 °C, 40% RH), hot (HOT, 35 °C, 60% RH) and hypoxic (HYP, 18 °C, 40% RH FiO2: 0.145) conditions.

Methods

Eleven well‐trained cyclists completed a 750 kJ cycling time trial in each condition on separate days in a counterbalanced order. EEG activity was recorded with α‐ and β‐activity evaluated in the frontal (F3 and F4) and central (C3 and C4) areas. Standardized low‐resolution brain electromagnetic tomography (sLORETA) was also utilized to localize changes in cerebrocortical activity.

Results

Both α‐ and β‐activity decreased in the frontal and central areas during exercise in HOT relative to CON (P < 0.05). α‐activity was also lower in HYP compared with CON (P < 0.05), whereas β‐activity remained similar. β‐activity was higher in HYP than in HOT (P < 0.05). sLORETA revealed that α‐ and β‐activity increased at the onset of exercise in the primary somatosensory and motor cortices in CON and HYP, while only β‐activity increased in HOT. A decrease in α‐ and β‐activity occurred thereafter in all conditions, with α‐activity being lower in the somatosensory and somatosensory association cortices in HOT relative to CON.

Conclusion

High‐intensity prolonged self‐paced exercise induces cerebrocortical activity alterations in areas of the brain associated with the ability to inhibit conflicting attentional processing under hot and hypoxic conditions, along with the capacity to sustain mental readiness and arousal under heat stress.
GSTP1 c.313A>G, XPD c.934G>A, XPF c.2505T>C and CASP9 c.‐1339A>G Polymorphisms and Severity of Vomiting in Head and Neck Cancer Patients treated with Cisplatin Chemoradiation
Authors: Carron Juliana , Lopes‐Aguiar Leisa , Costa Ericka Francislaine Dias , Nogueira Guilherme Augusto Silva , Lima Tathiane Regine Penna , Pincinato Eder Carvalho , Visacri Marilia Berlofa , Quintanilha Júlia Coelho França , Moriel Patrícia , Lourenço Gustavo Jacob , Lima Carmen Silvia Passos
Published: July 2017

Cisplatin (CDDP) chemotherapy associated with radiation (RT) has been used in advanced head and neck squamous cell carcinoma (HNSCC) patients, and vomiting is a common side effect during treatment. This prospective study aimed to identify the roles of GSTM1 and GSTT1 (presents or nulls), GSTP1 c.313A>G, XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C, ERCC1 c.354C>T, MLH1 c.−93G>A, MSH2 c.211 + 9C>G, MSH3 c.3133G>A, EXO1 c.1765G>A, TP53 c.215G>C, CASP3 c.‐1191A>G and c.‐1168G>T, CASP9 c.‐1339A>G, CASP8 c.‐937_‐932delAGTAAG, FAS c.‐1378G>A and c.‐671A>G, and FASL c.‐157‐687C>T single nucleotide polymorphisms, involved in CDDP metabolism, in vomiting severity in 88 HNSCC patients treated with CDDP and RT. Ondansetron and dexamethasone were administered as anti‐emetic therapy. Patients with GSTP1 c.313AG or GG genotype alone and combined with XPD c.934GA or AA, XPF c.2505TC or CC, and CASP9 c.‐1339AG or GG genotypes had 4.28, 5.00, 5.45 and 5.38 more chances of presenting moderate/severe vomiting than patients with others genotypes. Our data suggest, for the first time, that inherited abnormality in apoptosis pathway alone or combined with inherited abnormalities in DNA repair pathway, is capable of modulating emesis in HNSCC patients under CDDP chemoradiation and may be used for selecting patients who should receive pre‐emptive anti‐emetic therapy.