bluuebunny/crossref_metadata_2025 huggingface dataset:
An inverted pendulum with multibranching view as self-controlled system: Modelling and vibration absorber capacity
Authors: Fankem Eliane Raïssa , Nana Nbendjo Blaise Romeo , Woafo Paul , Dorka Uwe
Published: February 2020

The design and performance evaluation of a self-controlled system are investigated. An autonomous set of pendulums with different branches is considered. A mathematical model is derived, and the damping mechanism due to the transfer of energy between the central column and its attached branches is pointed out. The case of earthquake loads has been tested. Dynamics study shows that the energy received by the central column is distributed to the different branches, leading to a self-vibration control of the system. It is also found that one can increase the damping ratio according to the physical characteristics of the structure. This is a good candidate for earthquake protection of mechanical structures.
“It’s Global Warming, Stupid”: Aggressive Communication Styles and Political Ideology in Science Blog Debates About Climate Change
Authors: Yuan Shupei , Lu Hang
Published: February 2020

The current study examined the effects of aggressive communication styles on individuals’ pro-environmental behavioral intentions. Two underlying mechanisms—psychological reactance and expectancy violation—as well as the moderating role played by political ideology were investigated. An online experiment ( N = 423) was conducted and the results showed that more aggressive style was more likely to trigger psychological reactance and violation of expectation, liberals responded more negatively to the aggressive message than conservatives, and expectancy violation was an important mediator. The findings provide explanations for how communication styles affect individuals’ information processing and offer implications regarding selecting communication styles wisely.
Computational analysis of temperature distribution in microwave-heated potatoes
Authors: Singh Deepak , Singh Dhananjay , Husain Sattar
Published: February 2020

This research article reports the computational analysis of temperature distribution in microwave-heated convenience food such as potato. The detailed study of temperature (because temperature is a function of bacterial inactivation) and microwave powers along with drying time for the preservation of food material has been presented. Therefore, a mathematical model for potato sample is developed to predict the behavior of temperature distribution at each possible point and different shapes (slab, cylindrical, and spherical) of food material. The developed mathematical model is programmed by MATLAB software. Another parameter, microwave power is also a function of temperature. The ranging values of various microwave powers (125 W, 375 W, 625 W, 875 W, and 1250 W) along with different values of drying time (0 to 10 minutes) have been used for computation. The obtained results show the uniformity of temperature distribution throughout the whole product in the form of a three-dimensional structure. The model provides the minimum and maximum temperature ranges in specimens without performing an experiment which depicts the condition of bacterial inactivation.
An Open-Label Trial of Methylphenidate Treating Sluggish Cognitive Tempo, Inattention, and Hyperactivity/Impulsivity Symptoms Among 6- to 12-Year-Old ADHD Children: What Are the Predictors of Treatment Response at Home and School?
Authors: Fırat Sumeyra , Gul Hesna , Aysev Ayla
Published: February 2020

Objective: This study investigated the effects of sluggish cognitive tempo (SCT), other psychiatric symptoms, age, dose, and pretreatment ADHD severity on methylphenidate (MPH) treatment response among ADHD children in both home and school. In addition, the predictors of the MPH-SCT treatment response were examined. Methods: One hundred eighty-five (6–12 years old) ADHD children who were treated with MPH included in the study. Results: MPH improved SCT total and SCT-Daydreaming scores both at home and school while improved SCT-Sluggish scores in only school. Higher pretreatment Daydreaming score predicted lower treatment response for inattention ( B = .301, p = .002), and higher Daydreaming-Sluggish scores predicted lower treatment response for total ADHD symptoms at school ( B = .456, p = .006; B = .888, p = .04, respectively). Also higher oppositional defiant disorder symptoms have negative effects on MPH treatment response in ADHD. Older age positively affected the MPH-SCT treatment response in paternal and teacher ratings. Conclusion: SCT symptoms have negative effects on MPH treatment response at school.
HPC simulations of brownout: A noninteracting particles dynamic model
Authors: Porcù Roberto , Miglio Edie , Parolini Nicola , Penati Mattia , Vergopolan Noemi
Published: February 2020

Helicopters can experience brownout when flying close to a dusty surface. The uplifting of dust in the air can remarkably restrict the pilot’s visibility area. Consequently, a brownout can disorient the pilot and lead to the helicopter collision against the ground. Given its risks, brownout has become a high-priority problem for civil and military operations. Proper helicopter design is thus critical, as it has a strong influence over the shape and density of the cloud of dust that forms when brownout occurs. A way forward to improve aircraft design against brownout is the use of particle simulations. For simulations to be accurate and comparable to the real phenomenon, billions of particles are required. However, using a large number of particles, serial simulations can be slow and too computationally expensive to be performed. In this work, we investigate an message passing interface (MPI) + graphics processing unit (multi-GPU) approach to simulate brownout. In specific, we use a semi-implicit Euler method to consider the particle dynamics in a Lagrangian way, and we adopt a precomputed aerodynamic field. Here, we do not include particle–particle collisions in the model; this allows for independent trajectories and effective model parallelization. To support our methodology, we provide a speedup analysis of the parallelization concerning the serial and pure-MPI simulations. The results show (i) very high speedups of the MPI + multi-GPU implementation with respect to the serial and pure-MPI ones, (ii) excellent weak and strong scalability properties of the implemented time-integration algorithm, and (iii) the possibility to run realistic simulations of brownout with billions of particles at a relatively small computational cost. This work paves the way toward more realistic brownout simulations, and it highlights the potential of high-performance computing for aiding and advancing aircraft design for brownout mitigation.
The Obesity Paradox in Sepsis: A Theoretical Framework
Authors: Robinson Jamie , Swift-Scanlan Theresa , Salyer Jeanne , Jones Terry
Published: February 2020

Sepsis is a life-threatening syndrome that occurs in response to a severe infection. In recent years, the understanding of the pathobiology of sepsis has been refined, with research describing an altered host response as the underlying cause. Survivors of sepsis often have long hospital stays and suffer from subsequent frailty and long-term health consequences. Predicting attributes of sepsis survivors remains challenging; however, an obesity paradox exists, wherein obese individuals survive sepsis at higher rates than their normal-weight counterparts. We present a model that describes the relationships between sepsis and obesity, focusing on inflammation as a shared pathway for dysregulation in obese and healthy-weight adults. Understanding the interaction of these complex variables is an important first step toward developing interventions and treatments to augment sepsis survival.
Prospective growth and developmental outcomes in infants born to mothers with multiple sclerosis
Authors: Mahlanza Tatenda Dawn , Manieri Maria Claudia , Klawiter Eric C , Solomon Andrew J , Lathi Ellen , Ionete Carolina , Berriosmorales Idanis , Severson Christopher , Stankiewicz James , Cabot Ann , Elkort Michael , Chitnis Tanuja , Bove Riley , Katz Joshua , Houtchens Maria
Published: February 2020

Background:

The importance of supporting pregnancy-related decisions in multiple sclerosis (MS) patients has increasingly been recognized and hence the need for prospective data on pregnancy and pediatric outcomes in this patient population.

Objective:

To assess prospective growth and developmental outcomes of infants born to mothers with multiple sclerosis (IMS).

Methods:

PREG-MS is a prospective multicenter cohort study in New England, United States. We followed 65 women with MS and their infants with up to 12 months consistent pediatric follow-up. Pediatric, neurologic, and demographic information was obtained via structured telephone interviews and validated with medical records.

Results:

No differences in infant weights and lengths with World Health Organization (WHO) 50th percentile standards were observed ( p > 0.05). However, larger head circumference (HC) measurements than WHO standards were reported in cohort infants ( p < 0.05). There was no association between HC and markers of maternal MS activity, demographic, or social factors. No irreversible pediatric developmental abnormalities were observed.

Conclusion:

This first prospective study on pediatric anthropometry in IMS suggests a possible increase in HC compared to WHO standards without an increase in irreversible developmental abnormalities. The observations are exploratory and require confirmation with larger prospective studies in diverse groups of MS patients.
The parent and child experience of childhood vitiligo: An interpretative phenomenological analysis
Authors: Moss Kate , Johnston Samantha A , Thompson Andrew R
Published: February 2020

Vitiligo is a chronic and visible skin condition involving depigmentation with half of those with the condition developing it before the age of 20. This study sought to gain an experiential understanding of the impact of vitiligo on children and their parents. Interpretative phenomenological analysis was used, and semi-structured interviews were conducted with four child–parent dyads (eight participants). Analysis of the participants’ accounts revealed four overarching themes (Continuing Burden, The Significance of Visible Difference, Uncertainty and Unpredictability, and Coping), with 12 subthemes. There were some subtle differences between the parents and children. Both parents and child participants described the condition as posing a continuing burden with most participants reporting experiencing unwanted attention and being concerned about future relationship impact. Some parents described experiencing a sense of resignation to the condition, whereas all the children described a greater sense of acceptance. Nevertheless, acceptance seemed fragile, and parents were concerned that their children needed assistance in developing self-confidence. The findings represent the first in-depth analysis of childhood vitiligo.
The role of culture in early childhood curriculum development: A case study of curriculum innovations in Hong Kong kindergartens
Authors: Yang Weipeng , Li Hui
Published: February 2020

This study employed an inductive qualitative approach to understanding the effects of local culture on early childhood curriculum development in two Hong Kong kindergartens. A triangulation of interviews, observations and documents was established, and cultural-historical activity theory was employed as the theoretical framework. The results indicated that local culture played an important role in early childhood curriculum development. First, the two cases learned from diverse models and approaches during the transformation of their curricula, resulting in contradictory demands and motives. Then, these contradictions were, in turn, resolved by the local culture to achieve curriculum hybridisation and innovation, as well as inherit the culture. Such findings provide valuable implications for early childhood professionals to integrate social and cultural diversity into curriculum development and to localise imported curricular practices so as to ensure a good fit between the curriculum and the local context.
Vulnerabilities in a Dominant Receptor Subunit
Authors: Weston Matthew
Published: February 2020

[Box: see text]
Residual stress detection of welded parts based on excitation vibration response
Authors: Liu Xiaohan , Shi Guangfeng
Published: February 2020

With the rapid development of the equipment industry, people pay more attention to the stress research of materials. However, there is no more suitable and effective method to detect the variation of residual stress. To find an efficient and useful method to analyze the residual stress of the welded parts, this article selects the Q235 component as the research object and produces a detection robot with the core of processing vibration signal and extracting signal data. In combination with the vibration signal extracted by the robot, we study the influence law of the residual stress of the material through numerical simulation and experimental verification. The detection of residual stress is related to the change in the number of taps of the robot and the increase or decrease in the number of taps of the robot. We used the vibration signal extracted by the robot and analyzed the orthogonal parameters of the high-frequency induction welding process parameters to obtain a set of the most unique process parameters: The tapping angle was 7° and the tapping frequency was 300 Hz. We also set up the robot to extract and analyze the vibration signal using four different hammerheads. The results show that the sub-resonance analysis results as the standard, the deviation of the steel head and the aluminum head hammer is about ±10, the result is more accurate, and the frequency of the nylon and plastic hammer is lower, because it is softer. When the hammer is struck, the contact time of the hammerhead with the workpiece is lengthened, so that a lower frequency can be excited.
Adding new experimental arms to randomised clinical trials: Impact on error rates
Authors: Choodari-Oskooei Babak , Bratton Daniel J , Gannon Melissa R , Meade Angela M , Sydes Matthew R , Parmar Mahesh KB
Published: February 2020

Background:

Experimental treatments pass through various stages of development. If a treatment passes through early-phase experiments, the investigators may want to assess it in a late-phase randomised controlled trial. An efficient way to do this is adding it as a new research arm to an ongoing trial while the existing research arms continue, a so-called multi-arm platform trial. The familywise type I error rate is often a key quantity of interest in any multi-arm platform trial. We set out to clarify how it should be calculated when new arms are added to a trial some time after it has started.

Methods:

We show how the familywise type I error rate, any-pair and all-pairs powers can be calculated when a new arm is added to a platform trial. We extend the Dunnett probability and derive analytical formulae for the correlation between the test statistics of the existing pairwise comparison and that of the newly added arm. We also verify our analytical derivation via simulations.

Results:

Our results indicate that the familywise type I error rate depends on the shared control arm information (i.e. individuals in continuous and binary outcomes and primary outcome events in time-to-event outcomes) from the common control arm patients and the allocation ratio. The familywise type I error rate is driven more by the number of pairwise comparisons and the corresponding (pairwise) type I error rates than by the timing of the addition of the new arms. The familywise type I error rate can be estimated using Šidák’s correction if the correlation between the test statistics of pairwise comparisons is less than 0.30.

Conclusions:

The findings we present in this article can be used to design trials with pre-planned deferred arms or to add new pairwise comparisons within an ongoing platform trial where control of the pairwise error rate or familywise type I error rate (for a subset of pairwise comparisons) is required.
Designing clinical trials with (restricted) mean survival time endpoint: Practical considerations
Authors: Eaton Anne , Therneau Terry , Le-Rademacher Jennifer
Published: February 2020

Background/aims:

The difference in mean survival time, which quantifies the treatment effect in terms most meaningful to patients and retains its interpretability regardless of the shape of the survival distribution or the proportionality of the treatment effect, is an alternative endpoint that could be used more often as the primary endpoint to design clinical trials. The underuse of this endpoint is due to investigators’ lack of familiarity with the test comparing the mean survival times and the lack of tools to facilitate trial design with this endpoint. The aim of this article is to provide investigators with insights and software to design trials with restricted mean survival time as the primary endpoint.

Methods:

A closed-form formula for the asymptotic power of the test of restricted mean survival time difference is presented. The effects of design parameters on power were evaluated for the mean survival time test and log-rank test. An R package which calculates the power or the sample size for user-specified parameter values and provides power plots for each design parameter is provided. The R package also calculates the probability that the restricted mean survival time is estimable for user-defined trial designs.

Results:

Under proportional hazards and late differences in survival, the power of the mean survival time test can approach that of the log-rank test if the restriction time is late. Under early differences, the power of the restricted mean survival time test is higher than that of the log-rank test. Duration of accrual and follow-up have little influence on the power of the restricted mean survival time test. The choice of restriction time, on the other hand, has a large impact on power. Because the power depends on the interplay among the design factors, plotting the relationship between each design parameter and power allows the users to select the designs most appropriate for their trial. When modification is necessary to ensure the difference in restricted mean survival time is estimable, the three available modifications all perform adequately in the scenarios studied.

Conclusion:

The restricted mean survival time is a survival endpoint that is meaningful to investigators and to patients and at the same time requires less restrictive assumptions. The biggest challenge with this endpoint is selection of the restriction time. We recommend selecting a restriction time that is clinically relevant to the disease and the clinical setting of the trial of interest. The practical considerations and the R package provided in this work are readily available tools that researchers can use to design trials with restricted mean survival time as the primary endpoint.
Economic vulnerability and payment for research participation
Authors: Gelinas Luke , White Sarah A , Bierer Barbara E
Published: February 2020

There has been significant analysis of the ethical and regulatory issues involved with paying research participants, but less attention has been focused specifically on paying economically vulnerable individuals and the unique challenges it may present. This is important, as individuals of lower socio-economic standing are present in all disease groups and study populations. Moreover, clinical research is often conducted in economically under-developed locales, such as lower- or middle-income countries as well as impoverished locales of otherwise wealthy nations (such as, for example, rural Appalachia in the United States). Is it ethical to offer payment in such contexts? What are the ethical considerations relevant for determining payment rates and practices to individuals who are economically vulnerable? We offer an analysis of these issues, focusing on four unique areas of concern: (1) whether the risk of undue influence is greater for economically vulnerable individuals than for wealthier ones; (2) whether payment unacceptably raises the risk of ‘unjust influence’ or disproportionate representation of poor people in clinical research; (3) the positive reasons in favor of paying economically vulnerable people that stem from the ethical value of fairness; and (4) appropriate compensation rates for economically vulnerable populations. Our analysis supports the position that payment to economically vulnerable populations is ethically justified and indeed desirable when certain conditions are met.
Synthesis, cytotoxicity evaluation, and molecular modeling studies of 2,N10-substituted acridones as DNA-intercalating agents
Authors: Khunnawutmanotham Nisachon , Jumpathong Watthanachai , Eurtivong Chatchakorn , Chimnoi Nitirat , Techasakul Supanna
Published: February 2020

Acridine-based compounds possess anticancer activities by intercalating to DNA. Although they have chemotherapeutic potential, acridine-based compounds are not used to treat cancer. In this study, 2, N10-acridone derivatives are designed and synthesized based on acridone, a ketone derivative of acridine. Herein, acridone is functionalized with alkyl side chains containing terminal nitrogen-based moieties at the N10-position and substituted at the C2-position. The products are evaluated for in vitro cytotoxicity against four cancer cell lines: Molt-3, HepG2, A549, and HuCCA-1. The derivative bearing two butyl piperidine side chains at the C2- and N10-positions is the most active, with IC50 values ranging from 2.96 to 9.46 µM. Molecular modeling studies supported the binding of the derivatives to DNA by intercalation, thereby confirming the observed cytotoxic effects.
Interpreting great power rights in international society: Debating China’s right to a sphere of influence
Authors: Zala Benjamin
Published: February 2020

The special rights and responsibilities of the great powers have traditionally been treated as a key component – even a primary institution – of international society in the English School literature. Recent interpretivist work has focused on the meanings of special responsibilities in contemporary international society with far less scholarly attention being given to the corollary of this – special rights. This article uses an interpretivist approach to attempt to uncover what recent debates over China’s right or otherwise to a sphere of influence in East Asia tells us about understandings of great power rights in contemporary international society. The argument advanced is that if Beijing’s right to a sphere of influence is successfully rejected by the rest of international society without repudiating its status as a great power more broadly, China will indeed be a great power without historical precedent.
Noninvasive Continuous Monitoring of Vital Signs With Wearables: Fit for Medical Use?
Authors: Jacobsen Malte , Dembek Till A. , Kobbe Guido , Gaidzik Peter W. , Heinemann Lutz
Published: February 2020

Background:

Wearables (= wearable computer) enable continuous and noninvasive monitoring of a range of vital signs. Mobile and cost-effective devices, combined with powerful data analysis tools, open new dimensions in assessing body functions (“digital biomarkers”).

Methods:

To answer the question whether wearables are ready for use in the medical context, a PubMed literature search and analysis for their clinical-scientific use using publications from the years 2008 to 2018 was performed.

Results:

A total of 79 out of 314 search hits were publications on clinical trials with wearables, of which 16 were randomized controlled trials. Motion sensors were most frequently used to measure defined movements, movement disorders, or general physical activity. Approximately 20% of the studies used sensors to detect cardiovascular parameters. As for the sensor location, the wrist was chosen in most studies (22.8%).

Conclusion:

Wearables can be used in a precisely defined medical context, when taking into account complex influencing factors.
Severe Acute Localized Reactions Following Intra-Articular Hyaluronic Acid Injections in Knee Osteoarthritis
Authors: Ong Kevin L. , Runa Maria , Xiao Zhimin , Ngai Wilson , Lau Edmund , Altman Roy D.
Published: February 2020

Objective

Concerns have been raised about severe acute localized reactions (SALR) following intra-articular (IA) hyaluronic acid (HA) injections for knee osteoarthritis (OA). We compared surrogate SALR measures between hylan G-F 20 and non-hylan G-F 20 HA patients and evaluated corresponding SALR risk factors for hylan G-F 20 patients.

Design

Knee OA patients were identified from the Optum Clinformatics dataset (January 2006 to June 2016), stratified into hylan G-F 20 and non-hylan G-F 20 HA users. Occurrences of surrogate SALR measures including inflammation/infection, intra-articular corticosteroid (CS) injections, arthrocentesis/aspiration, and office visits were evaluated within 3 days of HA use. Risk factors were evaluated using logistic regression.

Results

The cohort involved 748,428 HA patients (23.2% in the hylan G-F 20 group). Inflammation/infection rate was 0.001% for hylan G-F 20 and 0.002% for non-hylan G-F 20 HA groups. Risk of CS injection (any diagnosis) was greater for hylan G-F 20 patients by 28% ( P < 0.001). Combined rates of CS injection and arthrocentesis/aspiration (any diagnosis) were comparable for both groups (hylan G-F 20, 2.2%; non-hylan G-F 20 HA, 2.6%). The risk of any visit or studied responses was lower for the hylan G-F 20 cohort by 12% ( P < 0.001). Clinical characteristics, such as CS injections within 1 week before HA and fluoroscopic imaging, were associated with the outcomes.

Conclusions

The diagnosis of inflammations or infections within 3 days of the HA injection was extremely rare. The overall risk of surrogate SALR measures was similar for hylan G-F 20 and non-hylan G-F 20 HA patients.
Verb Intergroup Bias: Verbs Are Used More Often in Reference to In-Groups than Out-Groups
Authors: Formanowicz Magdalena
Published: February 2020

Agency is a basic dimension of evaluations of social groups. More agency is assigned to in-groups than to out-groups, and verb intergroup bias (VIB) captures this tendency in language use. Four studies that performed large-scale quantitative analysis of natural language use, which covered more than 200 billion words, 20 countries, and various time spans, support the VIB model. Verbs, which are prototypically associated with actions, serve as agency indicators, and thus generic in-groups are more often described with verbs ( we vs. they). Moreover, VIB is present in specific between-group comparisons: for Americans as an in-group reference and various out-groups (e.g., Mexicans, Russians, and Palestinians), as well as for Americans, Canadians, Britons, and Australians as in-group references and immigrants as a generic out-group. VIB is a useful tool in diagnosing intergroup discourses. Furthermore, VIB attests to the importance of analyzing language’s role in the formation and maintenance of social biases.
The Development of Educational Aspirations and Expectations From Adolescence to Young Adulthood: A Longitudinal Study of Mexican-Origin Youth
Authors: Lawson Katherine M. , Atherton Olivia E. , Ferrer Emilio , Robins Richard W.
Published: February 2020

Mexican-origin youth are at increased risk for school dropout and low educational attainment. High educational aspirations and expectations provide a potential source of resilience, given their association with positive educational outcomes. Using data from a longitudinal study of 674 Mexican-origin youth, we examined the development of educational aspirations ("how far would you like to go in school?") and expectations ("how far do you actually expect to go?") from 7th grade ( M age = 12.8) to 2 years post–high school ( M age = 19.8). Results indicate that Mexican-origin youth enter adolescence with very high aspirations and expectations (e.g., 67% expect to graduate from college) and maintain them even after transitioning into young adulthood. Several demographic and cultural factors, including parent education level, family income, the cultural value of familism, ethnic identity, and Spanish language use, were associated with higher aspirations and expectations.
Blood glutamate scavenging as a novel glutamate-based therapeutic approach for post-stroke depression
Authors: Gruenbaum Benjamin F. , Kutz Ruslan , Zlotnik Alexander , Boyko Matthew
Published: February 2020

Post-stroke depression (PSD) is a major complication of stroke that significantly impacts functional recovery and quality of life. While the exact mechanism of PSD is unknown, recent attention has focused on the association of the glutamatergic system in its etiology and treatment. Minimizing secondary brain damage and neuropsychiatric consequences associated with excess glutamate concentrations is a vital part of stroke management. The blood glutamate scavengers, oxaloacetate and pyruvate, degrade glutamate in the blood to its inactive metabolite, 2-ketoglutarate, by the coenzymes glutamate–oxaloacetate transaminase (GOT) and glutamate–pyruvate transaminase (GPT), respectively. This reduction in blood glutamate concentrations leads to a subsequent shift of glutamate down its concentration gradient from the blood to the brain, thereby decreasing brain glutamate levels. Although there are not yet any human trials that support blood glutamate scavengers for clinical use, there is increasing evidence from animal research of their efficacy as a promising new therapeutic approach for PSD. In this review, we present recent evidence in the literature of the potential therapeutic benefits of blood glutamate scavengers for reducing PSD and other related neuropsychiatric conditions. The evidence reviewed here should be useful in guiding future clinical trials.
Sustained drug retention after paclitaxel-coated balloon angioplasty for superficial femoral artery disease: Follow-up intravascular imaging
Authors: Kobayashi Norihiro , Hirano Keisuke , Yamawaki Masahiro , Araki Motoharu , Sakai Tsuyoshi , Sakamoto Yasunari , Mori Shinsuke , Tsutsumi Masakazu , Nauchi Masahiro , Sahara Naohiko , Honda Yohsuke , Makino Kenji , Shirai Shigemitsu , Mizusawa Masafumi , Sugizaki Yuta , Nakano Takahide , Fukagawa Tomoya , Kishida Toshihiko , Kozai Yuki , Setonaga Yusuke , Goda Shutaro , Ito Yoshiaki
Published: February 2020

A 63 year-old woman with claudication underwent endovascular therapy for diffuse stenosis of the right superficial femoral artery in our hospital. We performed paclitaxel-coated balloon angioplasty using the IN.PACT™ Admiral™ and achieved acceptable results. After 42 days, we performed follow-up optical frequency domain imaging for the right superficial femoral artery lesion treated with paclitaxel-coated balloon and observed several high-intensity regions with attenuation on the lumen surface. Sustained drug availability is a notable characteristic of paclitaxel-coated balloon. To the best of our knowledge, this is the first report on the visualization of sustained drug retention on the lumen surface using follow-up optical frequency domain imaging after paclitaxel-coated balloon angioplasty in a human patient with superficial femoral artery disease.
Autism and attachment disorder symptoms in the general population: Prevalence, overlap, and burden
Authors: Minnis Helen , Messow Claudia-Martina , McConnachie Alex , Bradshaw Paul , Briggs Andrew , Wilson Philip , Gillberg Christopher
Published: February 2020

Background:

Co-occurring trauma-related and neurodevelopmental problems are common in maltreated children. In population research and clinical practice, these tend to be considered separately. Overlapping health problems, that is, “multi-morbidity,” in adulthood is associated with increased service burden and costs, but this has not been investigated in childhood.

Methods:

Using well-validated parent-report questionnaires, we examined the overlap between symptoms of the neurodevelopmental disorder autism (autism spectrum disorder, ASD) and symptoms of the trauma- and stressor-related disorders (reactive attachment disorder [RAD] and disinhibited social engagement disorder [DSED]) in a representative general population sample of over 3,300 children aged 5–6 years of age. We investigated sociodemographic factors, service burden, and costs in association with these problems when considered separately and when co-occurring.

Results:

Nearly 2% of this population had symptoms suggestive of both ASD and RAD/DSED. High symptom scores for ASD were associated with male gender, (younger) age of mother at birth, and being in a single-parent family, while high symptom scores for RAD/DSED were associated with (younger) age of mother at birth, being in a single-parent family, and the number of accidents reported. Service use costs per likely case of both ASD and RAD/DSED in the preschool years were increased by £348.62 (95% confidence interval 121.04–391.11)—nearly double the costs of ASD alone.

Conclusions:

There is considerable overlap between symptoms of ASD and RAD/DSED in the general population, indicating that multi-morbidity is already present in childhood and is associated with increased service use and costs even in the preschool years.
SPECS: a non-parametric method to identify tissue-specific molecular features for unbalanced sample groups
Authors: Everaert Celine , Volders Pieter-Jan , Morlion Annelien , Thas Olivier , Mestdagh Pieter
Published: February 2020

Background

To understand biology and differences among various tissues or cell types, one typically searches for molecular features that display characteristic abundance patterns. Several specificity metrics have been introduced to identify tissue-specific molecular features, but these either require an equal number of replicates per tissue or they can’t handle replicates at all.

Results

We describe a non-parametric specificity score that is compatible with unequal sample group sizes. To demonstrate its usefulness, the specificity score was calculated on all GTEx samples, detecting known and novel tissue-specific genes. A webtool was developed to browse these results for genes or tissues of interest. An example python implementation of SPECS is available at https://github.com/celineeveraert/SPECS. The precalculated SPECS results on the GTEx data are available through a user-friendly browser at specs.cmgg.be.

Conclusions

SPECS is a non-parametric method that identifies known and novel specific-expressed genes. In addition, SPECS could be adopted for other features and applications.
Genome-wide identification for genes involved in sodium dodecyl sulfate toxicity in Saccharomyces cerevisiae
Authors: Cao Chunlei , Cao Zhengfeng , Yu Peibin , Zhao Yunying
Published: February 2020

Background

Sodium dodecyl sulfate (SDS) is one of the most widely used anionic alkyl sulfate surfactants. Toxicological information on SDS is accumulating, however, mechanisms of SDS toxicity regulation remain poorly understood. In this study, the relationship between the SDS-sensitive mutants and their intracellular ROS levels has been investigated.

Results

Through a genome-scale screen, we have identified 108 yeast single-gene deletion mutants that are sensitive to 0.03% SDS. These genes were predominantly related to the cellular processes of metabolism, cell cycle and DNA processing, cellular transport, transport facilities and transport routes, transcription and the protein with binding function or cofactor requirement (structural or catalytic). Measurement of the intracellular ROS (reactive oxygen species) levels of these SDS-sensitive mutants showed that about 79% of SDS-sensitive mutants accumulated significantly higher intracellular ROS levels than the wild-type cells under SDS stress. Moreover, SDS could generate oxidative damage and up-regulate several antioxidant defenses genes, and some of the SDS-sensitive genes were involved in this process.

Conclusion

This study provides insight on yeast genes involved in SDS tolerance and the elevated intracellular ROS caused by SDS stress, which is a potential way to understand the detoxification mechanisms of SDS by yeast cells.
Prevalence of sarcopenia in multi ethnics adults and the association with cognitive impairment: findings from West-China health and aging trend study
Authors: Liu Xiaolei , Hou Lisha , Xia Xin , Liu Yang , Zuo Zhiliang , Zhang Yan , Zhao Wanyu , Hao Qiukui , Yue Jirong , Dong Birong
Published: February 2020

Background

Sarcopenia is a condition that is characterized by loss of muscle mass, muscle strength and muscle functional impairment with ageing. It is associated with poor health outcomes, premature death and a significant burden on the global health economy. The prevalence of sarcopenia in China is unknown since most of the studies are lack of uniform standard. The study was undertaken to study the prevalence of sarcopenia and the association with cognitive impairment among multi-ethnic adults aged 50 years old or older in western China.

Methods

We measured gait speed, handgrip strength and muscle mass by using bioelectrical impedance analysis (BIA) for all eligible participants and 4500 participants were eligible for the analysis. We defined sarcopenia using the diagnostic algorithm recommended by the Asian Working Group for Sarcopenia (AWGS). We assessed the participants’ cognitive functions using the 10-item Short Portable Mental Status Questionnaire (SPMSQ). Relationships between sarcopenia and cognitive impairment were analyzed using univariate and multivariate analyses.

Results

Of 4500 participants (mean age 62.4 ± 8.3 years), 869 (19.31%) adults were sarcopenia. 446 (9.9%) participants were identified as having mild cognitive impairment, 144 (3.2%) adults were identified as having moderate/severe cognitive impairment. After adjusting for age, gender, ethnics and other potential cofounders, cognitive impairment was found to be independently associated with sarcopenia with a dosage effect (mild cognitive impairment: odds ratio [OR]: 1.41, 95% CI 1.10–1.82; moderate/severe cognitive impairment: OR: 3.05, 95% CI 2.08–4.49). After gender stratification, the association between mild cognitive impairment with sarcopenia in male is not significant, while is still significant in female. While the association between moderate/severe cognitive impairment is independently associated with sarcopenia in both male and female.

Conclusions

The prevalence rates of sarcopenia, mild cognitive impairment, moderate/severe cognitive impairment among the communities aged 50 or older in western China were 19.31, 9.9 and 3.2%, respectively. Cognitive impairment was significantly associated with sarcopenia with a dosage effect, especially in female.
Preliminary comparison of three-dimensional reconstructed palatal morphology in subjects with different sagittal and vertical patterns
Authors: Huang Xiaoyi , Hu Xinnong , Zhao Yijiao , Wang Yong , Gu Yan
Published: February 2020

Background

The aim of this study was to assess the difference of palatal morphology in different vertical patterns between skeletal Class I subjects and skeletal Class II subjects with retrusive mandible.

Methods

Seventy-six skeletal Class II subjects with retrusive mandible (38 females, 38 males) and 85 skeletal Class I subjects (45 females, 40 males) were collected retrospectively and divided into hyperdivergent, normodivergent and hypodivergent groups. CBCT images of these subjects were reoriented by Dolphin 3D Imaging software. Three-dimensional (3D) maxilla was segmented by ProPlan software before using Geomagic Studio software to reconstruct 3D palatal morphology. Deviation patterns on 3D colored map analysis was performed to compare the difference of 3D palatal morphology between different groups.

Results

3D colored map analysis showed that male’s palate was higher and wider than that of female in the posterior part, regardless of different sagittal and vertical patterns. In skeletal Class II subjects with retrusive mandible, males with hyperdivergent and normodivergent showed higher and narrower in the posterior part of palate, while females with hyperdivergent and normodivergent had a higher but no obviously narrow palate compared with the hypodivergent subjects. Skeletal Class II subjects with retrusive mandible showed flatter and narrower in the posterior part of palate than that of skeletal Class I subjects.

Conclusions

Sagittal and vertical patterns have great influence on the palatal morphology and as the vertical dimension increased, the palate tended to be higher and narrower.
Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes
Authors: Witkowski Marco , Witkowski Mario , Saffarzadeh Mona , Friebel Julian , Tabaraie Termeh , Ta Bao Loc , Chakraborty Aritra , Dörner Andrea , Stratmann Bernd , Tschoepe Diethelm , Winter Samantha J. , Krueger Andreas , Ruf Wolfram , Landmesser Ulf , Rauch Ursula
Published: February 2020

Background

Diabetes mellitus is characterized by chronic vascular inflammation leading to pathological expression of the thrombogenic full length (fl) tissue factor (TF) and its isoform alternatively-spliced (as) TF. Blood-borne TF promotes factor (F) Xa generation resulting in a pro-thrombotic state and cardiovascular complications. MicroRNA (miR)s impact gene expression on the post-transcriptional level and contribute to vascular homeostasis. Their distinct role in the control of the diabetes-related procoagulant state remains poorly understood.

Methods

In a cohort of patients with poorly controlled type 2 diabetes (n = 46) plasma levels of miR-181b were correlated with TF pathway activity and markers for vascular inflammation. In vitro, human microvascular endothelial cells (HMEC)-1 and human monocytes (THP-1) were transfected with miR-181b or anti-miR-181b and exposed to tumor necrosis factor (TNF) α or lipopolysaccharides (LPS). Expression of TF isoforms, vascular adhesion molecule (VCAM) 1 and nuclear factor (NF) κB nuclear translocation was assessed. Moreover, aortas, spleen, plasma, and bone marrow-derived macrophage (BMDM)s of mice carrying a deletion of the first miR-181b locus were analyzed with respect to TF expression and activity.

Results

In patients with type 2 diabetes, plasma miR-181b negatively correlated with the procoagulant state as evidenced by TF protein, TF activity, d-dimer levels as well as markers for vascular inflammation. In HMEC-1, miR-181b abrogated TNFα-induced expression of flTF, asTF, and VCAM1. These results were validated using the anti-miR-181b. Mechanistically, we confirmed a miR-181b-mediated inhibition of importin-α3 (KPNA4) leading to reduced nuclear translocation of the TF transcription factor NFκB. In THP-1, miR-181b reduced both TF isoforms and FXa generation in response to LPS due to targeting phosphatase and tensin homolog (PTEN), a principal inducer for TF in monocytes. Moreover, in miR-181−/− animals, we found that reduced levels of miR-181b were accompanied by increased TF, VCAM1, and KPNA4 expression in aortic tissue as well as increased TF and PTEN expression in spleen. Finally, BMDMs of miR-181−/− mice showed increased TF expression and FXa generation upon stimulation with LPS.

Conclusions

miR-181b epigenetically controls the procoagulant state in diabetes. Reduced miR-181b levels contribute to increased thrombogenicity and may help to identify individuals at particular risk for thrombosis.
Impact of polyunsaturated fatty acids on patient-important outcomes in children and adolescents with autism spectrum disorder: a systematic review
Authors:   on behalf of the ISACA guideline working group, De Crescenzo Franco , D’Alò Gian Loreto , Morgano Gian Paolo , Minozzi Silvia , Mitrova Zuzana , Saulle Rosella , Cruciani Fabio , Fulceri Francesca , Davoli Marina , Scattoni Maria Luisa , Nardocci Francesco , Schünemann Holger Jens , Amato Laura
Published: February 2020

Background

Recent randomized controlled trials (RCTs) claimed PUFAs to be effective for autism spectrum disorder (ASD) but international guidelines have not considered yet this body of evidence. Our aim was to assess the effectiveness of PUFAs in children and adolescents with ASD, for the Italian national guidelines on the management of ASD in children and adolescents.

Methods

We performed a systematic review and meta-analysis of RCTs comparing PUFAs versus placebo or a healthy diet for the treatment of ASD in children and adolescents. The outcomes considered were deemed by the guideline panel to be highly relevant to children and adolescents with ASD and to their caregivers. The outcomes included hyperactivity, quality of sleep, self-harm, aggression, irritability, anxiety, attention, adaptive functioning, social interaction, restricted and repetitive interests and behavior, communication, hyperactivity and disruptive behaviors coexistent with core symptoms. The risk of bias of the included studies was assessed with the Cochrane tool, and the rating of the confidence in the effect estimates according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

Results

We included 9 studies with 405 participants. The strength of evidence ranged from low to very low. Six studies included preschoolers and school-age children, three studies included both children and adolescents. The majority of participants were males (83.8%), with a mean age of 6.7 years. PUFAs were superior compared to placebo in reducing anxiety in individuals with ASD (SMD -1.01, 95% CI − 1.86 to − 0.17; very low certainty of evidence). Moreover, PUFAs worsened quality of sleep compared to a healthy diet (SMD 1.11, 95% CI 0.21 to 2.00; very low certainty of evidence). PUFAs were not better than placebo in reducing aggression, hyperactivity, adaptive functioning, irritability, restricted and repetitive interests and behaviors and communication. Effects on some critical outcomes such as sleep, self-harm and disruptive behavior are currently unknown. The main limitations were the small number of participants included in the RCTs and the dosage which varied greatly (from 200 mg/day to 1540 mg/day), making it difficult to address causal inference.

Conclusions

PUFAs did not show evidence of effect in children and adolescents with ASD and the certainty of evidence as measured with the GRADE was low to very low. Further research is needed on this topic because the available evidence is inconclusive.