bluuebunny/crossref_metadata_2025 huggingface dataset:
A Seismic‐Frequency Laboratory Study of Solid Substitution in Bentheim Sandstone
Authors: Mikhaltsevitch V. , Lebedev M. , Gurevich B. , Sun Y. , Glubokovskikh S.
Published: May 2019

Studying the effects of the solid pore fills on the elastic properties of rocks is of significant importance for a range of applications, such as, for example, monitoring of heavy oil reservoirs or modeling the transport properties of the rocks affected by salt precipitation or cementation. We present the results of the laboratory solid‐substitution experiments carried out on Bentheim sandstone at a seismic frequency of 2 Hz. The experiments were performed when the pore space of the tested sample was filled sequentially with solid (23°C) and liquid (40°C) octadecane. Previously, ultrasonic measurements on the same octadecane‐filled sandstone showed significant discrepancy from the predictions of Ciz‐Shapiro theory, which was explained by the effect of stiffening of compliant pores at the grain contacts. However, the present results show good agreement with the predictions of the Ciz‐Shapiro theory and suggest that the effect of stiffening of the compliant pores in presence of solid is negligible at low frequency.
Soliton bursts and deterministic dissipative Kerr soliton generation in auxiliary-assisted microcavities
Authors: Zhou Heng , Geng Yong , Cui Wenwen , Huang Shu-Wei , Zhou Qiang , Qiu Kun , Wei Wong Chee
Published: May 2019

Dissipative Kerr solitons in resonant frequency combs offer a promising route for ultrafast mode-locking, precision spectroscopy and time-frequency standards. The dynamics for the dissipative soliton generation, however, are intrinsically intertwined with thermal nonlinearities, limiting the soliton generation parameter map and statistical success probabilities of the solitary state. Here, via use of an auxiliary laser heating approach to suppress thermal dragging dynamics in dissipative soliton comb formation, we demonstrate stable Kerr soliton singlet formation and soliton bursts. First, we access a new soliton existence range with an inverse-sloped Kerr soliton evolution—diminishing soliton energy with increasing pump detuning. Second, we achieve deterministic transitions from Turing-like comb patterns directly into the dissipative Kerr soliton singlet pulse bypassing the chaotic states. This is achieved by avoiding subcomb overlaps at lower pump power, with near-identical singlet soliton comb generation over twenty instances. Third, with the red-detuned pump entrance route enabled, we uncover unique spontaneous soliton bursts in the direct formation of low-noise optical frequency combs from continuum background noise. The burst dynamics are due to the rapid entry and mutual attraction of the pump laser into the cavity mode, aided by the auxiliary laser and matching well with our numerical simulations. Enabled by the auxiliary-assisted frequency comb dynamics, we demonstrate an application of automatic soliton comb recovery and long-term stabilization against strong external perturbations. Our findings hold potential to expand the parameter space for ultrafast nonlinear dynamics and precision optical frequency comb stabilization.
Intelligent ICU for Autonomous Patient Monitoring Using Pervasive Sensing and Deep Learning
Authors: Davoudi Anis , Malhotra Kumar Rohit , Shickel Benjamin , Siegel Scott , Williams Seth , Ruppert Matthew , Bihorac Emel , Ozrazgat-Baslanti Tezcan , Tighe Patrick J. , Bihorac Azra , Rashidi Parisa
Published: May 2019

Currently, many critical care indices are not captured automatically at a granular level, rather are repetitively assessed by overburdened nurses. In this pilot study, we examined the feasibility of using pervasive sensing technology and artificial intelligence for autonomous and granular monitoring in the Intensive Care Unit (ICU). As an exemplary prevalent condition, we characterized delirious patients and their environment. We used wearable sensors, light and sound sensors, and a camera to collect data on patients and their environment. We analyzed collected data to detect and recognize patient’s face, their postures, facial action units and expressions, head pose variation, extremity movements, sound pressure levels, light intensity level, and visitation frequency. We found that facial expressions, functional status entailing extremity movement and postures, and environmental factors including the visitation frequency, light and sound pressure levels at night were significantly different between the delirious and non-delirious patients. Our results showed that granular and autonomous monitoring of critically ill patients and their environment is feasible using a noninvasive system, and we demonstrated its potential for characterizing critical care patients and environmental factors.
Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization
Authors: Hans Chetan P. , Sharma Neekun , Sen Sidharth , Zeng Shuai , Dev Rishabh , Jiang Yuexu , Mahajan Advitiya , Joshi Trupti
Published: May 2019

Naïve macrophages (Mφ) polarize in response to various environmental cues to a spectrum of cells that have distinct biological functions. The extreme ends of the spectrum are classified as M1 and M2 macrophages. Previously, we demonstrated that Notch1 deficiency promotes Tgf-β2 dependent M2-polarization in a mouse model of abdominal aortic aneurysm. The present studies aimed to characterize the unique set of genes regulated by Notch1 signaling in macrophage polarization. Bone marrow derived macrophages isolated from WT or Notch1+/− mice (n = 12) were differentiated to Mφ, M1 or M2-phenotypes by 24 h exposure to vehicle, LPS/IFN-γ or IL4/IL13 respectively and total RNA was subjected to RNA-Sequencing (n = 3). Bioinformatics analyses demonstrated that Notch1 haploinsufficiency downregulated the expression of 262 genes at baseline level, 307 genes with LPS/IFN-γ and 254 genes with IL4/IL13 treatment. Among these, the most unique genes downregulated by Notch1 haploinsufficiency included fibromodulin (Fmod), caspase-4, Has1, Col1a1, Alpl and Igf. Pathway analysis demonstrated that extracellular matrix, macrophage polarization and osteogenesis were the major pathways affected by Notch1 haploinsufficiency. Gain and loss-of-function studies established a strong correlation between Notch1 haploinsufficiency and Fmod in regulating Tgf-β signaling. Collectively, our studies suggest that Notch1 haploinsufficiency increases M2 polarization through these newly identified genes.
Role of lipid composition on the structural and mechanical features of axonal membranes: a molecular simulation study
Authors: Saeedimasine Marzieh , Montanino Annaclaudia , Kleiven Svein , Villa Alessandra
Published: May 2019

The integrity of cellular membranes is critical for the functionality of axons. Failure of the axonal membranes (plasma membrane and/or myelin sheath) can be the origin of neurological diseases. The two membranes differ in the content of sphingomyelin and galactosylceramide lipids. We investigate the relation between lipid content and bilayer structural-mechanical properties, to better understand the dependency of membrane properties on lipid composition. A sphingomyelin/phospholipid/cholesterol bilayer is used to mimic a plasma membrane and a galactosylceramide/phospholipid/cholesterol bilayer to mimic a myelin sheath. Molecular dynamics simulations are performed at atomistic and coarse-grained levels to characterize the bilayers at equilibrium and under deformation. For comparison, simulations of phospholipid and phospholipid/cholesterol bilayers are also performed. The results clearly show that the bilayer biomechanical and structural features depend on the lipid composition, independent of the molecular models. Both galactosylceramide or sphingomyelin lipids increase the order of aliphatic tails and resistance to water penetration. Having 30% galactosylceramide increases the bilayers stiffness. Galactosylceramide lipids pack togetherviasugar-sugar interactions and hydrogen-bond phosphocholine with a correlated increase of bilayer thickness. Our findings provide a molecular insight on role of lipid content in natural membranes.
Behavioural and Neural Responses to Facial Disfigurement
Authors: Hartung Franziska , Jamrozik Anja , Rosen Miriam E. , Aguirre Geoffrey , Sarwer David B. , Chatterjee Anjan
Published: May 2019

Faces are among the most salient and relevant visual and social stimuli that humans encounter. Attractive faces are associated with positive character traits and social skills and automatically evoke larger neural responses than faces of average attractiveness in ventral occipito-temporal cortical areas. Little is known about the behavioral and neural responses to disfigured faces. In two experiments, we tested the hypotheses that people harbor a disfigured is bad bias and that ventral visual neural responses, known to be amplified to attractive faces, represent an attentional effect to facial salience rather than to their rewarding properties. In our behavioral study (N = 79), we confirmed the existence of an implicit ‘disfigured is bad’ bias. In our functional MRI experiment (N = 31), neural responses to photographs of disfigured faces before treatment evoked greater neural responses within ventral occipito-temporal cortex and diminished responses within anterior cingulate cortex. The occipito-temporal activity supports the hypothesis that these areas are sensitive to attentional, rather than reward properties of faces. The relative deactivation in anterior cingulate cortex, informed by our behavioral study, may reflect suppressed empathy and social cognition and indicate evidence of a possible neural mechanism underlying dehumanization.
Three-dimensional band structure and surface electron accumulation of rs-CdxZn1−xO studied by angle-resolved photoemission spectroscopy
Authors: Takahashi Kazutoshi , Imamura Masaki , Chang Jang Hyo , Tanaka Tooru , Saito Katsuhiko , Guo Qixin , Yu Kin Man , Walukiewicz Wladek
Published: May 2019

Three-dimensional band structure of rock-salt (rs) CdxZn1−xO (x = 1.0, 0.83, and 0.60) have been determined by angle-resolved photoemission spectroscopy (ARPES) using synchrotron radiation. Valence-band features shift to higher binding energy with Zn content, while the conduction band position does not depend strongly on Zn content. An increase of the indirect band gap with Zn-doping is larger than that of the direct band gap, reflecting a weaker hybridization between Zn 3d and O 2p than that between Cd 4d and O 2p. Two-dimensional electronic states due to the quantization along surface normal direction are formed in the surface accumulation layer and show non-parabolic dispersions. Binding energy of the quantized two-dimensional state is well reproduced using an accumulation potential with the observed surface band bending and the characteristic width of about 30 Å.
Therapeutic potential of coenzyme Q10 in mitochondrial dysfunction during tacrolimus-induced beta cell injury
Authors: Luo Kang , Yu Ji Hyun , Quan Yi , Shin Yoo Jin , Lee Kyung Eun , Kim Hong Lim , Ko Eun Jeong , Chung Byung Ha , Lim Sun Woo , Yang Chul Woo
Published: May 2019

We previously reported that oxidative stress induced by long-term tacrolimus treatment impairs mitochondrial function in pancreatic beta cells. In this study, we aimed to investigate the therapeutic potential of coenzyme Q10, which is known to be a powerful antioxidant, in mitochondrial dysfunction in tacrolimus-induced diabetic rats. In a rat model of tacrolimus-induced diabetes mellitus, coenzyme Q10 treatment improved pancreatic beta cell function. The administration of coenzyme Q10 improved insulin immunoreactivity within islets, which was accompanied by reductions in oxidative stress and apoptosis. Assessment of the mitochondrial ultrastructure by electron microscopy revealed that coenzyme Q10 treatment increased the size, number, and volume of mitochondria, as well as the number of insulin granules compared with that induced by tacrolimus treatment alone. An in vitro study using a pancreatic beta cell line showed that tacrolimus treatment increased apoptosis and the production of mitochondrial reactive oxygen species, while cotreatment with coenzyme Q10 effectively attenuated these alterations. At the subcellular level, tacrolimus-induced impairment of mitochondrial respiration was significantly improved by coenzyme Q10, as evidenced by the increased mitochondrial oxygen consumption and ATP production. Our data indicate that coenzyme Q10 plays an important role in reducing tacrolimus-induced oxidative stress and protects the mitochondria in pancreatic beta cells. These findings suggest that supplementation with coenzyme Q10 has beneficial effects in tacrolimus-induced diabetes mellitus.
A comparative genomics approach for identifying host-range determinants in Streptococcus thermophilus bacteriophages
Authors: Szymczak Paula , Rau Martin Holm , Monteiro João M. , Pinho Mariana G. , Filipe Sérgio Raposo , Vogensen Finn Kvist , Zeidan Ahmad A. , Janzen Thomas
Published: May 2019

Comparative genomics has proven useful in exploring the biodiversity of phages and understanding phage-host interactions. This knowledge is particularly useful for phages infecting Streptococcus thermophilus, as they constitute a constant threat during dairy fermentations. Here, we explore the genetic diversity of S. thermophilus phages to identify genetic determinants with a signature for host specificity, which could be linked to the bacterial receptor genotype. A comparative genomic analysis was performed on 142 S. thermophilus phage genomes, 55 of which were sequenced in this study. Effectively, 94 phages were assigned to the group cos (DT1), 36 to the group pac (O1205), six to the group 5093, and six to the group 987. The core genome-based phylogeny of phages from the two dominating groups and their receptor binding protein (RBP) phylogeny corresponded to the phage host-range. A role of RBP in host recognition was confirmed by constructing a fluorescent derivative of the RBP of phage CHPC951, followed by studying the binding of the protein to the host strain. Furthermore, the RBP phylogeny of the cos group was found to correlate with the host genotype of the exocellular polysaccharide-encoding operon. These findings provide novel insights towards developing strategies to combat phage infections in dairies.
Cell cycle dynamics of mouse embryonic stem cells in the ground state and during transition to formative pluripotency
Authors: Waisman Ariel , Sevlever Federico , Elías Costa Martín , Cosentino María Soledad , Miriuka Santiago G. , Ventura Alejandra C. , Guberman Alejandra S.
Published: May 2019

Mouse embryonic stem cells (mESCs) can be maintained as homogeneous populations in the ground state of pluripotency. Release from this state in minimal conditions allows to obtain cells that resemble those of the early post-implantation epiblast, providing an important developmental model to study cell identity transitions. However, the cell cycle dynamics of mESCs in the ground state and during its dissolution have not been extensively studied. By performing live imaging experiments of mESCs bearing cell cycle reporters, we show here that cells in the pluripotent ground state display a cell cycle structure comparable to the reported for mESCs in serum-based media. Upon release from self-renewal, the cell cycle is rapidly accelerated by a reduction in the length of the G1 phase and of the S/G2/M phases, causing an increased proliferation rate. Analysis of cell lineages indicates that cell cycle variables of sister cells are highly correlated, suggesting the existence of inherited cell cycle regulators from the parental cell. Together with a major morphological reconfiguration upon differentiation, our findings support a correlation between this in vitro model and early embryonic events.
Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation
Authors: Dai Dongfang , Yuan Jia , Wang Yan , Xu Jing , Mao Chaoming , Xiao Yichuan
Published: May 2019

Chronic neuroinflammation is known to contributes to the toxicity of neurodegeneration of Parkinson’s disease (PD). However, the molecular and cellular mechanisms controlling inflammatory responses in the central nervous system remain poorly understood. Here we found that a E3 ubiquitin ligase Peli1 is dramatically induced only in the substantia nigra (SN) of the human and mouse PD brains. The ablation of Peli1 significantly suppressed LPS-induced production of neurotoxic mediators and proinflammatory cytokines in SN and in primary microglia, whereas Peli1 is dispensable for the inflammatory responses in astrocyte. Accordingly, Peli1 deficiency markedly inhibited neuron death induced by the conditioned medium from LPS-stimulated microglia. Mechanistical study suggested that Peli1 acts as a positive regulator of inflammatory response in microglia through activation of NF-κB and MAP kinase. Our results established Peli1 as a critical mediator in the regulation of microglial activation and neuroinflammation-induced death of dopaminergic neurons during PD pathogenesis, suggesting that targeting Peli1 may have therapeutic effect in neuroinflammation.
Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice
Authors: Li Meng , Dang Yanqi , Li Qiong , Zhou Wenjun , Zuo Jianping , Yao Zemin , Zhang Li , Ji Guang
Published: May 2019

Berberine (BBR) is a widely used anti-diabetic agent, and liver glucokinase (GK) has been reported to be involved. However, the mechanisms of BBR in regulating GK are still unknown. Here, we found that BBR upregulated GK immunofluorescence expression in AML12 cells cultured in high glucose and increased glycogen content simultaneously. BBR improved hyperglycemia in db/db mice, and increased liver glucose-6-phosphate/glucose-1-phosphate (G-6-P/G-1-P) was found by analyzing metabolites (serum, liver, and feces) based on gas chromatography-mass spectrometry (GC-MS) metabolomics. Pharmacokinetics-pharmacodynamics (PK-PD) assessment revealed enriched BBR distribution in the liver, and liver G-6-P had the same trend as the concentration-time curve of BBR. G-6-P is solely catalyzed by GK, and GK activity and expression showed a positive correlation with liver BBR levels. In db/db mice, BBR also upregulated GK in liver fractions (cytoplasm and nucleus) and liver glycogen content. GK functionally worked by dissociating from GK regulatory protein (GKRP), and although GKRP expression was not affected, we found a decreased ratio of GK binding with GKRP in BBR treated db/db mice. In conclusion, our study suggests the dissociation of GK from GKRP as the potential mechanism for liver GK increase upon BBR treatment, which contributes to the anti-diabetic effect of BBR.
Cascade intramolecular imidoylation and C–H activation/annulation of benzimidoyl chlorides with alkynes: one-pot synthesis of 7H-dibenzo[de,h]quinoline analogues
Authors: Liu Jiao , Fang Hao , Cheng Rui , Wang Zhishuo , Yang Yudong , You Jingsong
Published: May 2019

Described herein is a cascade Lewis acid-promoted intramolecular Friedel–Crafts-type imidoylation and Rh(iii)-catalyzed C–H activation/annulation of benzimidoyl chlorides and alkynes, providing a divergent synthetic shortcut to 7H-dibenzo[de,h]quinoline analogues.
The transient reduction of NO with CO and naphthalene in the presence of oxygen using a core–shell SmCeO2@TiO2-supported copper catalyst
Authors: Venegas Fernanda , López Naima , Sánchez-Calderón Luis , Aguila Gonzalo , Araya Paulo , Guo Xuyun , Zhu Ye , Guerrero Sichem
Published: May 2019

This work studied the reaction of common pollutants on a catalytic surface under oxidizing conditions.
Allylic oxidation of olefins with a manganese-based metal–organic framework
Authors: Chen Jingwen , Chen Minda , Zhang Biying , Nie Renfeng , Huang Ao , Goh Tian Wei , Volkov Alexander , Zhang Zhiguo , Ren Qilong , Huang Wenyu
Published: May 2019

Manganese-based CPF-5 as a highly efficient catalyst for the selective aerobic oxidation of cyclohexene to cyclohexenone under mild conditions.
An isophorone-based NIR probe for hydrazine in real water samples and hermetic space
Authors: Shi Xinrong , Huo Fangjun , Chao Jianbin , Zhang Yongbin , Yin Caixia
Published: May 2019

The role of hydrazine in production is not to be underestimated due to its strong reducibility. However, every coin has two sides.
New functional material: spark plasma sintered Si/SiO2 nanoparticles – fabrication and properties
Authors: Dorokhin M. V. , Gavva V. A. , Ved' M. V. , Demina P. B. , Kuznetsov Yu M. , Erofeeva I. V. , Nezhdanov A. V. , Boldin M. S. , Lantsev E. A. , Popov A. A. , Trushin V. N. , Vikhrova O. V. , Boryakov A. V. , Yakimov E. B. , Tabachkova N. Yu.
Published: May 2019

A bulk nanostructured material based on oxidized silicon nanopowder was fabricated using a spark plasma sintering technique.
Identification and characterization of differentially expressed miRNAs in HepG2 cells under normoxic and hypoxic conditions
Authors: Kong Fanzhi , Ran Wei , Jiang Ning , Li Shize , Zhang Dongjie , Sun Dongbo
Published: May 2019

MicroRNAs (miRNAs) are important post-transcriptional regulators involved in hypoxia conditions; however, their roles in HepG2 cells remain poorly understood.
Effects of lipid composition on membrane distribution and permeability of natural quinones
Authors: Teixeira Murilo Hoias , Arantes Guilherme Menegon
Published: May 2019

Lipid acyl chain unsaturation modulates the barrier for ubiquinone flip-flop over the membrane.
A glassware-free combinatorial synthesis of green quantum dots using bubble wrap
Authors: Mann P. Bergstrom , Afzal K. , Long N. J. , Thanou M. , Green M.
Published: May 2019

In this communication, we highlight the use of bubble wrap in the simple parallel synthesis of CuInS2-based quantum dots with different optical properties, based on varying precursors concentrations.
Ultrafast synthesis of AFX-Type zeolite with enhanced activity in the selective catalytic reduction of NOx and hydrothermal stability
Authors: Chokkalingam Anand , Chaikittisilp Watcharop , Iyoki Kenta , Keoh Sye Hoe , Yanaba Yutaka , Yoshikawa Takeshi , Kusamoto Tetsuro , Okubo Tatsuya , Wakihara Toru
Published: May 2019

SSZ-16 (AFX-type) zeolite prepared in 2 h, so far the fastest, shows enhanced hydrothermal-stability and activity in selective-catalytic-reduction of NOx.
A new iron-based metal–organic framework with enhancing catalysis activity for benzene hydroxylation
Authors: Tu Thach N. , Nguyen Hue T. T. , Nguyen Huong T. D. , Nguyen My V. , Nguyen Trinh D. , Tran Nhung Thi , Lim Kwon Taek
Published: May 2019

A new Fe-based MOFs catalyst was used for benzene hydroxylation with the high phenol yield (64.5%) and selectivity (92.9%).
The influence of molecular geometry on the efficiency of thermally activated delayed fluorescence
Authors: Nobuyasu Roberto S. , Ward Jonathan S. , Gibson Jamie , Laidlaw Beth A. , Ren Zhongjie , Data Przemyslaw , Batsanov Andrei S. , Penfold Thomas J. , Bryce Martin R. , Dias Fernando B.
Published: May 2019

We report a strategy for positively influencing the conformation of thermally activated delayed fluorescence (TADF) molecules containing phenothiazine and dibenzothiophene-S,S-dioxide units.
Advances towards the utilization of Vis-NIR light energy by coating YF3:Yb3+,Er3+ over ZnS microspheres triggering hydrogen production and pollutants disposal
Authors: Li Xiaoxiao , Yang Kai , Yu Changlin , Yang Shi , Zhang Kailian , Dai Wenxin , Ji Hongbing , Zhu Lihua , Huang Weiya , Ouyang Shaobo
Published: May 2019

Harvesting abundant and environmentally friendly near infrared (NIR) light in the solar spectrum is particularly significant to improve the utilization of the cleanest energy on the earth and the control of environmental pollution.
C-reactive protein gene 1846C>T polymorphism is associated with increased risk and clinical features of lung cancer: a case–control study
Authors: Chen Chen , Liu Jing-Ni , Zhao Jian-Qiang , Zang Bao
Published: May 2019

Chronic inflammation plays an important role in lung carcinogenesis. Recently, several studies investigated the association of C-reactive protein (CRP) gene 1846C>T polymorphism and lung cancer (LC) risk, but with conflicting findings. In the present study, we conducted this case–control study with 408 LC patients and 472 healthy controls in a Chinese Han population. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLR) method. Our data found that CRP gene 1846C>T polymorphism increased the risk of LC. Subgroup analyses obtained significant associations among the groups of males, ≥50 years old, smoking, and non-drinkers. Bioinformatics analysis showed that the expression levels of CRP in LC tissues were significantly increased compared with normal tissues. Additionally, the present study found CRP mRNA high expression was associated with worse survival in LC patients. Furthermore, our data indicated that TT genotype of 1846C>T polymorphism was associated with a larger size of tumor and was related with lymphatic metastasis in LC patients. In conclusion, the present study suggests that CRP gene 1846C>T polymorphism is associated with increased risk of LC. CRP gene 1846C>T polymorphism may be a potential marker for the diagnosis of LC.
S-ethyl ethanethiosulfinate, a derivative of allicin, induces metacaspase-dependent apoptosis through ROS generation in Penicillium chrysogenum
Authors: Qi Feilong , Zhang Chen , Jiang Shanshan , Wang Qian , Kuerban Kudelaidi , Luo Man , Dong Mengxue , Zhou Xinguang , Wu Laiming , Jiang Biao , Ye Li
Published: May 2019

Allicin can be used as fumigant to protect food and cultural relics from fungal contamination because of its strong antifungal activity and the characteristics of high volatility and no residues. However, the obvious disadvantages such as high minimal inhibitory concentration and instability prevent it from wide application. In this study, a stable derivative of allicin, S-ethyl ethanethiosulfinate (ALE), was synthesized. We further explored its antifungal activity and apoptosis-inducing effect, as well as the underlying mechanism. ALE had an excellent capability of inhibiting spore germination and mycelial growth of Penicillium chrysogenum observed by inverted microscope and scanning electron microscopy. XTT colorimetric assay indicated ALE could reduce the cell viability obviously and IC50 was 0.92 μg/ml, only 1/42 of allicin (38.68 μg/ml). DHR 123 ROS Assay Kit, flow cytometry assay and confocal immunofluorescence revealed intercellular ROS generation and metacaspase-dependent apoptosis triggered by ALE, while antioxidant tocopherol could reverse ALE-induced cytotoxicity effect and metacaspase activation. These results indicate that ALE induces metacaspase-dependent apoptosis through ROS generation, thus possesses an effective antifungal activity. This new derivative of allicin might be developed as a high efficient alternative to the conventional fungicides for food storage and cultural relic protection.
Big data technology in construction
Authors: Garyaev Nikolay , Garyaeva Venera
Published: May 2019

The article presents the results of the analysis of the use of large amounts of data in the construction industry, new trends such as BIM, IOT, cloud computing, intelligent buildings and smart cities with great prospects for application. These problems are related to the presence of huge amounts of data produced by the construction industry during the entire life cycle of a building, which are not fully used for optimizing processes and making decisions in construction.
Computer Research of Building Materials
Authors: Vasil’eva Olga
Published: May 2019

A computer study of the technological processes for the production of building materials based on the use of reversible autocatalysis reactions is carried out. For the mathematical description of the process of autocatalytic reactions, mathematical models are used, described by a initial-boundary problems for the Carleman system. The considered mathematical model describes the autocatalysis reaction under the following assumptions: the rate of decrease in the density of positive ions is proportional to the square of the deviation of the density of positive ions from the equilibrium state, the rate of decrease in the density of negative ions is proportional to the square of the deviation of the density of negative ions from the equilibrium position and the law of conservation of the total charge of the system including liquid solution. This mathematical model is non-linear, therefore numerical methods are used for its study. For a numerical solution of the initial-boundary value problem for the Carleman system, a finite-difference method of the second order of accuracy is used. For the numerical investigation of the solution obtained, linear interpolation and spline interpolation are used. A numerical study is made on the dependence of the chemical reaction time from the parameters of the model and various initial conditions.
Parameters of heat treatment increased concrete strength at its watertightness
Authors: Asatov Nurmuhamat , Tillayev Mirjalol , Raxmonov Navruzbek
Published: May 2019

One of the effective methods of land irrigation in the Republic of Uzbekistan is carried out with the help of precast reinforced concrete trays of irrigation systems. In the process of operation, precast concrete trays are influenced by difficult operating conditions. As is known, to achieve high water resistance and concrete strength after heat treatment, it is necessary to take into account such factors as pre-exposure time, temperature rise rate, and isothermal warm-up time. However, the determining factor that has the greatest impact on the water resistance of concrete during heat treatment is the duration of the preliminary exposure and the rate of temperature rise, on which the values of internal stresses in concrete depend on heating. The paper gives the results of scientific research, which, being based on the studies of heat and moisture treatment of concrete in a laboratory steam chamber with automatic control of the regime. Scientific methods and techniques were used in the process of data processing and study findings: systematic approach, methods of system analysis and mathematical statistics. To determine the strength of concrete, cubic samples were made with dimensions of 100×100×100 mm, which were tested at the period of 1,3,7,28 days. After HMT compared with similar characteristics of normal hardening samples. The results of studies of the kinetics of increase in concrete strength depending on the heat treatment regimes are shown in the paper, that, despite the slight difference in the duration of the preliminary curing (1 and 2 hours), there is still a certain difference between them. The scientific novelty lies in the formulation, formalization and solving problems related to water resistance, frost resistance, and at the same time saves heat and power resources of trays.
Material stone-concrete – selection of composition for concrete face rockfill dams
Authors: Bestuzheva Alexandra , Tsipurskiy Ilya , Gadai Dimitri
Published: May 2019

The properties of the face zone material as a flexible foundation of the face play an extremely important role in the formation of stress-strain state of rockfill dams with reinforced concrete face. Stone-concrete, made by watering the stone backfill with cement-sand mix containing water-reducing agents is proposed to be used as such foundation in the paper. Methods of selecting the composition of the casting mixture and search results of its optimal composition by the method of factor analysis are given in this paper. The properties of stone-concrete are investigated and a dam design technique is developed based on the selection of optimal properties for the face zone of that material.
Contact strength of C-S-H cement phase
Authors: Ovcharenko Gennadiy , Ibe Ekaterina , Sandrasheva Aizhana , Viktorov Artem
Published: May 2019

The object of the study was the cement phase C-S-H – X-ray amorphous calcium hydrosilicates, obtained by steaming at 80°C together limestone and silica at different molar ratios CaO/SiO2 = 0.5; 1.0; 1.5. The contact strength of the C-S-H phase with additions of portlandite, silica and alumina zols, high-aluminate slag was estimated by hyper-pressing method with subsequent destruction. It was established that the contact strength of the cement phase increases in proportion to the specific pressing pressure, the age of samples and inversely the phase basicity reaching 12 MPa. It was evidenced that additives increase the contact strength of the C-S-H stone. The features of the phase formation during the hydration of calcium aluminates were considered. It was established that there is no negative effect of additional porosity on the strength of the stone, because the restructuring of calcium hydroaluminates takes place during hyper-pressing. The specific behavior of low-basic calcium aluminates in a mixture with the C-S-H phase was established in the case of using high-aluminate slag, which consists in additional formation Al(OH)3 gel during the hydration, that is provide an increase in the contact strength of the compositions.
Properties of gypsum composites with sawdust
Authors: Regulska Katarzyna , Repelewicz Aleksandra
Published: May 2019

Gypsum composites have been gaining increasing interest within last decades. Nowadays, the environment-supporting options are regaining more advocates. Thus, organic fillers are back in game. The physical and mechanical properties of gypsum composites with sawdust were tested and are described in the paper. The influence of gypsum mixture composition, the water/gypsum ratio and appropriate mineralization on the composite properties were examined. Present study focuses on the durability, thermal properties, natural radioactivity and susceptibility to biological corrosion of the tested materials.
Lamb waves in multilayered media: 3D and 6D formalisms
Authors: Avershyeva Anna , Kuznetsov Sergey
Published: May 2019

A mathematical model for analyzing Lamb waves propagating in stratified media with arbitrary elastic anisotropy is worked out. The model incorporates a combined Fundamental Matrix (FM) and Modified Transfer Matrix (MTM) methods. Multilayered unbounded plates with different types of boundary conditions imposed on the outer surfaces are considered. Closed form fundamental matrices and secular equations for dispersion relations are derived.
Chemical hazards in construction industry
Authors: Kowalik Tomasz , Logoń Dominik , Maj Marek , Rybak Jarosław , Ubysz Aleksandra , Wojtowicz Anna
Published: May 2019

Rapid technological progress in construction requires that more and more attention should be paid to human security issues. Threats occur both at the stage of building facilities and during their use. Some impacts are easy to identify during construction stage like shocks and vibrations, others are hidden from sight and direct sensing like the harmful effect of chemicals. In addition to accidents that happen on construction sites, there are still objective threats, which may occur throughout the lifetime of the facility. In addition to clearly perceptible ones such as earthquakes, hurricanes, fires, there are hidden threats as well: bacteriological contamination, radiation or chemical interactions that occur in time. This article points to the most common chemical hazards. Examples of chemical threats occurring in construction at the stages of design, construction and use of buildings will be given below.
Industrial constructive system of civil buildings of increased survivability
Authors: Fedorova Nataliya , Tamrazyan Ashot , Korenkov Pavel
Published: May 2019

The paper considers a new industrial constructive system of residential and public buildings that meets modern requirements for protection against progressive collapse, improved space-planning, architectural and thermal protection solutions. The presence of a significant number of enterprises with technological lines for the production of structures for large-panel housing construction and their share in the market, combined with a number of shortcomings of the technical and space-planning solutions used, indicate the need to modernize these enterprises for their production to meet modern requirements. The purpose of this study was to develop an industrial constructive system of civilian buildings with increased resistance to progressive collapse, the production of which would not require expensive modernization of the construction industry enterprises. Based on the level calculation schemes, an algorithm is proposed for calculating such a system for a particular emergency impact. Numerical studies have established the correspondence of the developed constructive system to the requirements of a special limiting state under design loads and accidental effects caused by the disconnection of the vertical bearing from work.
Statistical modeling of the assembly of single-layer domes
Authors: Lebed Evgeny
Published: May 2019

A special purpose software SBORKA was developed by the author, which is intended for numerical modeling of the assembly process of single-layer lattice domes with respect to random deviations in lengths of individual bars. The dispersion of the inaccuracies in the sizes of bars is consistent with the normal distribution law, and their values are limited by the tolerances corresponding to 3σ. The assembly of a single-layer dome frame is simulated by sequentially calculating the coordinates of its nodes based on the imitation of the connection in these nodes of individual bars. Imperfections in the lengths of the bars lead to the fact that the actual geometric shape of the dome frame will differ from the design shape. Reliable analysis of the nature of the possible errors of the frames of single-layer lattice domes can only be performed by multiple assembly simulations with subsequent statistical processing of the obtained results. For the implementation of numerical statistical simulation of the assembly, the algorithm of the software includes procedures for solving various spatial problems of computational geometry. Computational procedures implemented in the software for modeling the assembly process are described in this paper.
Bearing capacity of elements of a gas transportation system
Authors: Pirumyan Narine , Stakyan Mihran
Published: May 2019

The issues of improving the methods of calculation and design of the gas transmission system (GTS) are considered, taking into account the analysis of loading modes and peculiarities of its individual nodes. The analysis of design schemes for evaluating the performance of elements of the gas transmission system according to the strength criterion is given, and a probabilistic method for assessing the reliability of butt welds of pipelines is selected. The features of the operating conditions of the system are considered and the method for calculating equivalent strength indicators and loading modes is presented. A unified approach is applied for determining the probability level of failure-free operation of parts and components of a structure. A comparative analysis of traditional and new methods for assessing the performance of the considered system is given. The interval values of the parameters included in the dependence to determine the probability level of a failure-free operation of a welded joint are clarified. A computational method is proposed, which allows to increase the carrying capacity of the GTS in the probabilistic aspect.
Pile group settlement analysis on the basis of Static Load Test
Authors: Dudek Nikola
Published: May 2019

Settlement of large pile groups is most often estimated by the Alternative Foundation Method. However, this method has some limitations related to assumed uniformity of pile loads. A very big problem is also related to estimating the stiffness of subgrade loaded by a group of piles. Similar problems arise when piled foundation is numerically modelled in Finite Element Method or Boundary Element Method programmes. The results obtained are highly dependent on the input data, especially on characteristics describing soil subgrade stiffness and strength and moduli at pile – soil contact. The paper presents an example of using the results of trial static calculations for the pile made using a technology not identical with that ultimately implemented for the project. The subgrade stiffness modulus was determined with Inverse Analysis using bored pile test load. The results attained were used for further calculations (forecast) the settlement of prefabricated driven pile (a single one) and then to estimate of pile group settlement under full load from bridge structure abutment.
Side busking of the cantilever beam with narrow rectangular cross section
Authors: Yazyev Serdar , Zotov Ivan , Vysokovsky Dmitriy , Yazyev Batyr
Published: May 2019

The problem of lateral buckling of a cantilever strip with a constant narrow cross section loaded with a concentrated force at the end of the span is considered. In the study of lateral buckling of beam energy method was used. For the case of load application in the center of gravity, the problem is reduced to a generalized secular equation. The relationship between the magnitude of the critical force and the position of the point of application of the load. A comparison of the results obtained by the authors with an analytical solution using infinite series and a numerical iterative method is shown.
Dynamic methods of spatial calculation of structures based on a plate model
Authors: Toshmatov Elyor , Usarov Makhamtali , Ayubov Gayratjon , Usarov Davronbek
Published: May 2019

This article was devoted to the development of methods of the dynamic calculation based on the finite difference method of laminar structures in the framework of the bimoment theory, which takes into account the spatial stress-strain state. Were given the solutions of the problem of transverse vibrations of the plate model of structures.
Structural alternatives of high embankment dams
Authors: Kotov Filipp
Published: May 2019

At present the types of seepage-control elements made of non-soil materials are worked out for construction of ultra-high embankment dams. We made assessment of workability of a number of new structural designs of seepage-control elements for embankment dams such as concrete core, grout curtain, massive face, combined seepage-control elements. The assessment was made by analyzing the results of numerical modeling of more than 200 m high dam stress-strain state. It was revealed that the most perspective way of constructing high embankment dams is use of combined seepage-control elements. The operative structures are structures consisting of a reinforced concrete face and a vertical structure (like a diaphragm or a curtain), made of clay and cement mix. Use of internal seepage-control elements made of rigid materials in high embankment dams is dangerous.
Numerical solutions of the problem of salt-transfer in soils
Authors: Yusupov Majid , Rahkmankulova Barna , Aynakulov Sharofiddin
Published: May 2019

Work is devoted to work out of effective numerical methods of the decision of problems of forecasting of mineralization of a soil solution taking into account of differential porosity and sorption and dissolution processes. The algorithm of the decision of a problem consists of the following sequence action. On time are used quadrature to the formula and regional problems with any boundary conditions dare a method of differential prorace. Testing of the program realising algorithm of the offered method of calculation it is carried out by the decision of the known problems, having practical application.
Water regimes of rice fields
Authors: Nurjanov Satbay
Published: May 2019

The article is a review work, periodic moistening - a layer of water is absent throughout the entire growing season of rice, optimum soil moisture is created through periodic irrigation. Mostly applied permanent and shortened flooding. The most promising is the water regime with shortened flooding. Depending on the method of sowing, debris from the rice field by grasslands and soil salinization, there are various options for this mode. Rice plant, like any other, imposes different requirements for water in different phases of the growing season. The best medium for rice in the period of germination and in the phase of emergence is a moist soil. To obtain seedlings on highly saline soils with a close level of saline groundwater, the most favorable is a small layer of water, which is periodically replaced.
A model of the labor productivity dependence on workforce density
Authors: Pergamenshchik Boris , Undozjorov Vadim
Published: May 2019

The paper reviews the dependence of labor productivity on the number of workers within a unit of working area (i.e. workforce density) in the construction sector. The relevance of the problem is demonstrated. Some limitations of the linear model for the dependence, assumed in the construction sector, are discussed. These limitations are linked up with the neglect of labor productivity reduction due to the increased density. The proposed by some researchers concepts which account for the above factor are listed. Their drawbacks are indicated, and the necessity of further research is shown. A “hyperbolic model” is proposed, in which one worker productivity is constant for a certain workforce density rate and then it drops down with the increasing speed. Work productivity reduction in such model is described by the “hyperbolic growth” function. The primary approbation of the model was done for some construction operations at the nuclear power plant reactor building. The density rate was optimized (as per deadline reduction criterion) for this case according to the “hyperbolic model”.
Sip-technology as solution in low-rise multi-family residential buildings
Authors: Lapidus Azariy , Ndayiragije Yves
Published: May 2019

The article is devoted to the study of the possibility of using SIP-technology in solving the problem of housing shortages in Bujumbura. The author analyzed the design features of houses, foreign experience in the development of low-rise construction, the advantages of using SIP-panels compared to other building materials. Organizational and technological solutions for the construction of low-rise apartment buildings using SIP-panels will help to provide the population with comfortable housing at an affordable price. The SIP-technology enables the construction in places with difficult terrain due to their difficult engineering and geological conditions.
Replacement of floor structures in capital repair with the use of not extractable void formers
Authors: Afanasyev Grigoriy
Published: May 2019

Urgency of the floor structures replacement is driven by the program of capital repair of the residential buildings adopted by the government and stipulates replacement of wood coverings by armored concrete floors that enable increase of stability, fire-resistance and cost effectiveness. Wood partitions and other elements of planning made of materials with low fire-resistance are also subject to replacement.

It has been shown that the use of void formers allows reducing consumption of concrete, reinforcement, reduces duration of building and energy consumption. Thereby the stability and fire-resistance increase of the buildings under renovation is achieved. Solving these tasks is the objective of the represented work.

It is worth noting that when renovating buildings the data about the use of not extractable void formers are absent. The technology development is an author’s initiative.

The goal of the investigations consists in analyzing the works of the domestic and foreign scientists that make it possible to assess effectiveness of the technology when erecting buildings of cast in-situ reinforced concrete with the use of void formers.

The submitted work has carried out the adaptation of the works performance technology in confined spaces of capital repair. Optimization of the void formers selection has been made, node points of the slabs’ resting on brick walls have been developed, the technology of dismantlement, form work, reinforcing, installation of void formers and concrete pouring has been developed.

The complex of the works provides for obtainment of floor structures with the lesser consumption of concrete and reinforcement..