bluuebunny/crossref_metadata_2025 huggingface dataset:
Edges deletion problem of hypercube graphs for some n
Authors: Jasim Anwar N. , Najim Alaa A.
Published: April 2024

Numerous graph-theoretic methods can be used to investigate the efficiency and reliability of networks. The reliability of a network is determined based on its connectivity. At the very least, the system must continue to function in the event of part of its component (node or link) failures. An ideal system remains reliable even when errors occur. Diameter is a measure of network efficiency used to study the effects of link failures in networks. In this paper, we look into the eliminating edges affect to the hypercube graph’s diameter (call it by [Formula: see text]) and calculate the maximum diameter that is denoted by [Formula: see text] after deleting [Formula: see text] edges from hypercube graphs [Formula: see text] for some n.
On strong incidence coloring of subcubic graphs
Authors: Mousavi Fatemeh Sadat , Nouri Masoumeh
Published: April 2024

An incidence of a graph [Formula: see text] is a pair [Formula: see text] where [Formula: see text] is a vertex of [Formula: see text] and [Formula: see text] is an edge of [Formula: see text] incident with [Formula: see text]. Two incidences [Formula: see text] and [Formula: see text] of [Formula: see text] are adjacent whenever (i) [Formula: see text], or (ii) [Formula: see text] or (iii) [Formula: see text] or [Formula: see text]. A strong incidence coloring of a graph [Formula: see text] is a mapping from the set of incidences of [Formula: see text] to the set of colors [Formula: see text], such that every two incidences that are adjacent, or adjacent to the same incidence receive distinct colors. In this paper, we prove that every connected subcubic graph [Formula: see text] except [Formula: see text] has a strong incidence coloring with at most [Formula: see text] colors.
STOCK MARKET RESPONSE TO METEOROLOGICAL DISASTER RISK: FROM LIQUIDITY PERSPECTIVE
Authors: WU JIE , WANG YUNONG , YANG XIAOGUANG
Published: April 2024

This study investigates the impact of meteorological disaster risk perception on stock liquidity of Chinese listed companies by constructing meteorological disaster risk perception indicators through the Baidu index. Empirical evidence reveals that an increase in meteorological disaster risk perception decreases investors’ risk appetite and increases investors’ loss aversion, which in turn negatively affects stock liquidity. In addition, the increase in meteorological disaster risk perception also shrinks stock trading volume by reducing investor sentiment. The negative effect of meteorological disaster risk perception on stock liquidity is more pronounced in summer and winter and for firms located in water-rich areas. The findings of this study provide empirical evidence from investors’ perspective for understanding the impact of meteorological disasters on stock market liquidity.
Trust and Lending: An Experimental Study
Authors: Hyndman Kyle , Wu Jiabin , Xiao Steven Chong
Published: April 2024

This paper investigates the importance and the determinants of trust in a lending situation using a controlled experiment. We find that communication can facilitate collaboration between lenders and borrowers through three channels of trust: (1) an information channel, (2) a preference channel, and (3) a reciprocity channel. Our results highlight the role of trust in mitigating the moral hazard problem in lending.
Parallel Hierarchical Multi-View Feature Fusion Based on Canonical Correlation Analysis for Mammogram Retrieval
Authors: Abderrahim Marwa , Baâzaoui Abir , Barhoumi Walid
Published: April 2024

Due to the diversity of image sources, content-based multi-source image fusion and retrieval have shown promising capabilities in computer vision tasks, and especially when applied in Computer-Aided Diagnosis (CAD) to automate and improve the accuracy of medical image analysis. The combination of computer vision and CAD systems has the potential to revolutionize healthcare by augmenting the expertise of clinicians, improving overall diagnostic accuracy and helping experts in the clinical decision-making process by classifying and retrieving similar annotated clinical images to a given query. In the context of multi-view mammography interpretation, the concept of multi-view feature fusion has recently been studied to improve retrieval performance while effectively guaranteeing the complementarity of both MLO and CC views. However, conventional multi-view feature fusion makes descriptors long and lacks to take into consideration the relationship between descriptors. To deal with this issue, we propose two hierarchical multi-view feature fusion methods, for multi-view mammogram retrieval, based on the Canonical Correlation Analysis (CCA), which is the most commonly used multivariate parametric test. In fact, we have adapted CCA to determine the relationship between two descriptors by processing latent correlation factors. Moreover, after extracting descriptors for each view, a comparative study of texture and shape fusion descriptors is proposed in order to identify the more discriminative features for multi-view mammogram retrieval. Then, a query-dependent distance metric preserving both visual resemblance and semantic similarity is carried out to dynamically determine the more appropriate distance measure for each query image. Extensive experiments on the challenging Curated Breast Imaging Subset of Digital Database for Screening Mammography (CBIS-DDSM) have demonstrated the effectiveness of the proposed hierarchical multi-view feature fusion for mammogram retrieval, which outperforms the performance achieved either by conventional fused information or by single view information. To improve the transparency of our paper, the source code of the proposed method and the related dataset (including readme files) are publicly accessible through the following GitHub link: https://github.com/ABDERRAHIMMAR/Multi-View-Feature-Fusion-for-Mammogram-Retrieval . This open-access resource empowers researchers and practitioners to delve deeper into our methodology, fostering collaboration and advancements in the field of computer-aided diagnosis and medical image analysis.
Investigating Superconducting State Parameters in (TaNb)X(TiZrHf)1−X Compounds: A First Principle Approach Employing MS Excel as Toolkit
Authors: Kumar Ashwani , Sachan Amol
Published: April 2024

This paper employs a first-principle approach to systematically investigate the superconducting state parameters in (TaNb)X(TiZrHf)[Formula: see text] alloys (where X varies from 0 to 1). Utilizing advanced computational techniques, we elucidate the critical factors influencing the superconducting behavior of this mixed-metal system. Our study provides valuable insights into the tuning of critical temperature ([Formula: see text]) and other essential parameters, offering a comprehensive understanding of the superconducting properties. It has been that, due to the simple averaging effect of the individual density of states (DOS) contributions and consistent increase in the electrostatic repulsion between ions, the DOS and Coulomb pseudopotential increase linearly with concentration. The lattice disorder and weak isotope effect affect the electron–phonon coupling strength thereby affecting the critical temperature ([Formula: see text]) of the material. The outcomes contribute to the design and optimization of novel superconductors with potential applications.
Optimization for stochastic model arisen from investment problem associated with default risk
Authors: Yao Nian , Xiao Mingqing , Wu Songbin
Published: April 2024

In this paper, we study the optimal strategy arisen from the excess-of-loss reinsurance and asset allocation in defaultable markets under a general stochastic model. By developing the corresponding dynamic programming approach, we establish the optimal investment approach through two sub-problems: a pre-default case and a post-default case, respectively, characterized by the obtained Hamilton–Jacobi–Bellman (HJB) equations. We show the existence of a classical solution to the pre-default case via super-sub solution techniques and give an explicit characterization of the optimal reinsurance and investment policy that maximizes the common used utility associated with the terminal wealth. Verification theorem is further established to show the uniqueness of the corresponding solution of HJB equation that is critical to the desired optimal solution.
Graph Convolutional Gated Recurrent Unit Network for Traffic Prediction Using Loop Detector Data
Authors: Shoman Maged , Aboah Armstrong , Daud Abdulateef , Adu-Gyamfi Yaw
Published: April 2024

Traffic prediction is challenging due to the stochastic nonlinear dependencies in spatiotemporal traffic characteristics. We introduce a Graph Convolutional Gated Recurrent Unit Network (GC-GRU-N) to capture the critical spatiotemporal dynamics. Using 15-min aggregated Seattle loop detector data, we recontextualize the prediction challenge across space and time. We benchmark our model against Historical Average, LSTM, and Transformers. While Transformers outperformed other models, our GC-GRU-N came in a close second with notably faster inference time — six times quicker than Transformers. We offer a comprehensive comparison of all models based on training and inference times, MAPE, MAE, and RMSE. Furthermore, we delve into the spatial and temporal characteristics of each model’s performance.
Vendor-Locked DevOps Strategies
Authors: Dunbar William
Published: April 2024

Using vendor-locked DevOps solutions and getting away with it.
Partial Server Pooling in Delay Systems
Authors: Rohit V Hari , Mete Akshay , Manjunath D , Nair Jayakrishnan , Prabhu Balakrishna
Published: April 2024

We consider a strategic resource pooling interaction between two service providers, each of which is modelled as a multi-server queue. The traditional full resource pooling mechanism, while improving the overall system performance measure, may not always benefit the providers individually. For rational service providers, there will therefore be no incentive to form a stable coalition. We address this issue by proposing three partial sharing mechanisms: two of these, Partial Pooling with Dedicated Servers and Partial Pooling with Repacking, allow each provider to designate a certain number of servers to potentially serve jobs of the other provider, while the third mechanism, Differential Queue Length, maintains an upper bound on the difference between occupancies of the two queues. We determine the probability of waiting for each of the three mechanisms and show through several numerical examples that their Pareto frontiers are non-empty. In particular, this shows that the proposed partial pooling mechanisms are individually beneficial to both providers and incentivize coalition formation in all situations. Finally, we apply bargaining theory to determine the operating point on the Pareto frontier.
Color Hint-guided Ink Wash Painting Colorization with Ink Style Prediction Mechanism
Authors: Zeng Yao , Liu Xiaoyu , Wang Yijun , Zhang Junsong
Published: April 2024

We propose an end-to-end generative adversarial network that allows for controllable ink wash painting generation from sketches by specifying the colors via color hints. To the best of our knowledge, this is the first study for interactive Chinese ink wash painting colorization from sketches. To help our network understand the ink style and artistic conception, we introduced an ink style prediction mechanism for our discriminator, which enables the discriminator to accurately predict the style with the help of a pre-trained style encoder. We also designed our generator to receive multi-scale feature information from the feature pyramid network for detail reconstruction of ink wash painting. Experimental results and user study show that ink wash paintings generated by our network have higher realism and richer artistic conception than existing image generation methods.
A Spatial Constraint Model for Manipulating Static Visualizations
Authors: Liu Can , Zhang Yu , Wu Cong , Li Chen , Yuan Xiaoru
Published: April 2024

We introduce a spatial constraint model to characterize the positioning and interactions in visualizations, thereby facilitating the activation of static visualizations. Our model provides users with the capability to manipulate visualizations through operations such as selection, filtering, navigation, arrangement, and aggregation. Building upon this conceptual framework, we propose a prototype system designed to activate pre-existing visualizations by imbuing them with intelligent interactions. This augmentation is accomplished through the integration of visual objects with forces. The instantiation of our spatial constraint model enables seamless animated transitions between distinct visualization layouts. To demonstrate the efficacy of our approach, we present usage scenarios that involve the activation of visualizations within real-world contexts.
Designing Socially Assistive Robots Exploring Israeli and German Designers’ Perceptions
Authors: Liberman-Pincu Ela , Korn Oliver , Grund Jonas , van Grondelle Elmer D. , Oron-Gilad Tal
Published: April 2024

Socially assistive robots (SARs) are becoming more prevalent in everyday life, emphasizing the need to make them socially acceptable and aligned with users’ expectations. Robots’ appearance impacts users’ behaviors and attitudes toward them. Therefore, product designers choose visual qualities to give the robot a character and to imply its functionality and personality. In this work, we sought to investigate the effect of cultural differences on Israeli and German designers’ perceptions of SARs’ roles and appearance in four different contexts: a service robot for an assisted living/retirement residence facility, a medical assistant robot for a hospital environment, a COVID-19 officer robot, and a personal assistant robot for domestic use. The key insight is that although Israeli and German designers share similar perceptions of visual qualities for most of the robotics roles, we found differences in the perception of the COVID-19 officer robot’s role and, by that, its most suitable visual design. This work indicates that context and culture play a role in users’ perceptions and expectations; therefore, they should be taken into account when designing new SARs for diverse contexts.
The Bis(monoacylglycero)-phosphate Hypothesis: From Lysosomal Function to Therapeutic Avenues
Authors: Medoh Uche N. , Abu-Remaileh Monther
Published: April 2024

Lysosomes catabolize and recycle lipids and other biological molecules to maintain cellular homeostasis in diverse nutrient environments. Lysosomal lipid catabolism relies on the stimulatory activity of bis(monoacylglycero)phosphate (BMP), an enigmatic lipid whose levels are altered across myriad lysosome-associated diseases. Here, we review the discovery of BMP over half a century ago and its structural properties that facilitate the activation of lipid hydrolases and recruitment of their coactivators. We further discuss the current, yet incomplete, understanding of BMP catabolism and anabolism. To conclude, we discuss its role in lysosome-associated diseases and the potential for modulating its levels by pharmacologically activating and inhibiting the BMP synthase to therapeutically target lysosomal storage disorders, drug-induced phospholipidosis, Alzheimer's disease, Parkinson's disease, frontotemporal dementia, cancer, and viral infection.
Causes and Consequences of Varying Transposable Element Activity: An Evolutionary Perspective
Authors: Betancourt Andrea J. , Wei Kevin H.-C. , Huang Yuheng , Lee Yuh Chwen G.
Published: April 2024

Transposable elements (TEs) are genomic parasites found in nearly all eukaryotes, including humans. This evolutionary success of TEs is due to their replicative activity, involving insertion into new genomic locations. TE activity varies at multiple levels, from between taxa to within individuals. The rapidly accumulating evidence of the influence of TE activity on human health, as well as the rapid growth of new tools to study it, motivated an evaluation of what we know about TE activity thus far. Here, we discuss why TE activity varies, and the consequences of this variation, from an evolutionary perspective. By studying TE activity in nonhuman organisms in the context of evolutionary theories, we can shed light on the factors that affect TE activity. While the consequences of TE activity are usually deleterious, some have lasting evolutionary impacts by conferring benefits on the host or affecting other evolutionary processes.
The United States in the World Today: How Sociologists Think About It and Why It Matters
Authors: Mallard Grégoire , Barol Shirin , Kiderlin Nina Teresa
Published: April 2024

The study of policy alone often means domestic policy, of interest to generalist sociologists interested in how political ideas are turned into domestic legislation, executive action, and/or court litigation. Foreign policy, as the financial, commercial, diplomatic and military relations of a state with foreign states, remains a niche subfield. But foreign relations should be conceived of as the broader set of entanglements between societies, encompassing transnational movements, expert networks, and fields. Then, sociological theories of foreign relations can interest generalist sociologists. In this review, we illustrate how this broad view of foreign relations applies to the study of the United States in the world today (USitWT) by first surveying how sociologists of the world society and world system have focused on transnational relations and the place of the United States in their dynamics, and how they have engaged with the question of power. We then demonstrate how field theorists’ study of transnational fields can allow sociologists to reconceptualize the historical role of the USitWT by highlighting continuities between European colonial governmentalities and current US transnational practices. This field perspective can allow sociologists to understand the USitWT as transnational, postcolonial, or neo-colonial governmentality, depending on the sociological and historical depth and range of its relation with different parts of the world.
Design of Pentacene Thin-Film Transistor Based Hydrogen Gas Sensor with High-K Dielectric Materials for High Sensitivity
Authors: Thakur Yogesh , Raj Balwinder , Raj Balwant
Published: April 2024

Electrical properties of an organic field-effect transistor were modelled in top gate top contact (TGTC) geometry and H2 gas sensors were designed for increased sensitivity based on the structure. Safety concerns related to hydrogen usage must be addressed; these hazardous characteristics include a wide flammable range (4%–75%) that results in a rapid burning velocity, a low minimum ignition energy (0.017 mJ), a high heat of combustion (143 kJ g−1), and the high diffusivity of hydrogen gas (0.61 cm2 s−1 in the air). These characteristics make it impossible to control hydrogen combustion after a specific time. All simulations were performed in the Silvaco TCAD ATLAS tool. We analysed the driving principle of gas sensors and introduced gas sensing properties in OFET using platinum metal at the gate electrode for H2 gas detection. IOFF, ION, and VTH are sensitivity parameters that alter when the metalwork function of the gate changes with respect to the gas present on it. The designed sensor was analysed for different dielectric materials. Results demonstrate that the increase in sensitivity for OFET-based H2 sensors is 73.4%, 80.7%, 90.5%, and 95.6% when the work function changes by 50, 100, 150, and 200 meV for Pt gate electrodes with an increase in dielectric value of insulating layer from SiO2 (3.9) to La2O3 (27). Results were compared with the In1-xGaxAs CGNWFET-based H2 sensor as the work function varies at 200 meV,the sensitivity enhancement with OFET-based H2 sensors is 8.09%.
The Inverted Case Study Technique: changing the traditional case-study approach to prioritize physiological mechanisms over correct diagnosis and treatment
Authors: Brainard Robert E. , Terson de Paleville Daniela G. L. , Long Michael C. , Hughes Daniel G. , Watson Lewis J. , Anderson Gary
Published: April 2024

This article presents a novel approach to century-old learning techniques that enhances students’ self-reported learning and also their attitudes toward learning mechanistic physiology and increases their perception of preparedness for professional school.
A partially flipped physiology classroom improves the deep learning approach of medical students
Authors: Liu Ziqi , Xu Yangting , Lin Yicheng , Yu Pei , Ji Ming , Luo Ziqiang
Published: April 2024

In this article, we compare the impact of the partially flipped classroom (PFC) and the traditional lecture classroom (TLC) in a physiology course on medical students’ learning approaches. We found that the PFC benefited students by significantly enhancing their deep learning motive, strategy, and approach, which was good for them. However, the TLC model only improved the surface learning motive and approach.
Esm-1 mediates transcriptional polarization associated with diabetic kidney disease
Authors: Gaudet Alexandre , Zheng Xiaoyi , Kambham Neeraja , Bhalla Vivek
Published: April 2024

Esm-1 is primarily expressed in glomerular endothelium in humans. Cells expressing Esm1 exhibit a high degree of conservation in the enrichment of genes related to blood vessel development. In the context of diabetes, these cells are reduced in number and show a significant transcriptional shift toward the chemotaxis pathway. In diabetes, there is a transcriptional polarization in the glomerulus that is reflected by the degree of Esm1 deficiency.
Cerebrovascular dysfunction and depressive symptoms in preclinical models: insights from a scoping review
Authors: Menon Nithin J. , Sun Clara , Chhina Jashnoor , Halvorson Brayden D. , Frisbee Jefferson C. , Frisbee Stephanie J.
Published: April 2024

This scoping review presents a structured evaluation of all relevant existing literature linking cerebral vasculopathy to depressive symptom emergence in preclinical models. Results support a definite connection between vascular dysfunction and depressive symptoms, highlighting the importance of chronic elevations in inflammation and oxidant stress, and impaired serotonergic signaling. The review also identified significant knowledge gaps addressing male versus female differences and limited clear mechanistic links between cerebral vasculopathy and depressive symptoms.
Effects of Static Stretching on the Blood Circulation of Human Tendon In Vivo
Authors: Yasuda Ayaka , Kubo Keitaro
Published: April 2024

The purpose of this study is to compare the effects of 2- and 5 min of static stretching protocols on the changes in blood circulation of tendon (as well as muscle) and heart rate. Twelve healthy males (age: 26.2 ± 9.1 yrs) volunteered for this study. Before, during stretching, during the recovery period (30 min), blood circulation (oxyhemoglobin; oxy, deoxyhemoglobin; deoxy, blood volume; THb, oxygen saturation; StO2) of the Achilles tendon and medial gastrocnemius muscle were measured using red laser lights and near-infrared spectroscopy. In addition, heart rate was measured during the experimental period. For 2- and 5 min of static stretching, oxy, deoxy, THb, and StO2 of the tendon did not change during or after stretching. Regarding muscle blood circulation, oxy and StO2 decreased, and deoxy and THb increased during 2- and 5 min of static stretching but returned immediately upon completion. In addition, heart rate significantly reduced during and after stretching, whereas the changes in blood volume of tendon and muscle during stretching were not associated with those in heart rate (except for the relationship between tendon THb and heart rate in 2 min of static stretching). These results suggest that static stretching showed no change in tendon blood circulation, although muscle blood circulation during stretching was altered. In addition, significant heart rate reduction with static stretching was not associated with changes in tendon and muscle blood circulation.
Enhancing the Trajectories of Cancer Health Disparities Research: Improving Clinical Applications of Diversity, Equity, Inclusion, and Accessibility
Authors: Martini Rachel , Gebregzabher Endale , Newman Lisa , Davis Melissa B.
Published: April 2024

In order to accurately detect and prevent racial disparities, self-reported race (SRR) and ethnicity remain valuable tools; however, inaccurate capture of patient identity and broad aggregation of minoritized race groups present challenges for data interpretation. Also, although SRR is a proxy for shared social/cultural experience, it is not an accurate representation of shared endogenous factors. Biological investigations into cancer disparities, particularly those involving genetic features, should be framed in the context of genetic background or ancestry, as these are heritable aspects of population health. In reality, both genetics and environment work in concert to influence cancer risk and clinical outcomes. The best opportunity to define actionable means for reducing health disparities is in rigorous and comprehensive generation of rich data sets that characterize environmental, biological, and genetic components of disparate disease burden. To translate this pivotal disparities research into clinical tools and improved policies, we describe a diversity, equity, inclusion, and accessibility (DEIA) framework, which will increase participation from diverse backgrounds, reexamine previous research with a rigorous evaluation of appropriate SRR groupings, and engage community leaders to ensure that future research addresses the needs of communities at increased risk. On this path forward, we may finally end cancer disparities.
La alimentación en educación inicial como un campo de experiencia pedagógica
Authors: Pulido Serrano Ana Julieta Pulido Serrano
Published: April 2024

Este artículo presenta los resultados de la sistematización de la experiencia realizada en la Fundación Inti Huasi: Casa del Sol, institución Waldorf, ubicada en la localidad de Teusaquillo, en Bogotá. La sistematización de la experiencia como proceso inductivo plantea una reflexión sobre la práctica dentro de su contexto natural, en una apuesta por visibilizar los aprendizajes que fortalecen la propuesta de educación de niños como parte de una perspectiva pedagógica que integra la alimentación al resignificar su valor para el desarrollo humano como uno de los ejes fundamentales que permiten la transformación de las condiciones de bienestar y aprendizaje. Los resultados de esta investigación se encuentran estructurados en cinco secciones: la reconstrucción colectiva de la experiencia, saberes, formas de acción, sentidos y significados, y conclusiones.
Caracterización de una experiencia de interacción educativa dialógica de apropiación social de la ciencia y la tecnología, con niños en edad temprana, en ámbitos no formales, a partir de la sistematización del Club Pequeños Exploradores de Maloka
Authors: Sequeda Herrera Sandra Liliana
Published: April 2024

El presente artículo condensa los resultados de la tesis realizada en el marco de la Maestría de Desarrollo Educativo y Social, en convenio entre el Cinde y la Universidad Pedagógica Nacional. El artículo presenta la lógica de sentido, la propuesta metodológica y el sistema relacional que caracterizan una experiencia de interacción educativa dialógica de apropiación social de la ciencia y la tecnología, con niños en edad temprana, en ámbitos no formales, a partir de la sistematización del Club Pequeños Exploradores de Maloka. Esta sistematización implicó el abordaje de cuatro periodos, desde la creación del Club en el 2003, hasta el 2012, en el contexto del convenio interinstitucional entre el Centro Interactivo Maloka y la Universidad Pedagógica Nacional. Realizar esta sistematización puso en evidencia elementos característicos de la experiencia del Club que la investigadora había vivido en el proceso, los cuales se reflexionaron pedagógicamente. Es importante poner de manifiesto que la sistematización, como modalidad investigativa, se ha ido transformando en parte sustancial del quehacer profesional de la investigadora, como fruto de la inmersión en la maestría.
Producir para consumir: videojuegos de roles multijugador en línea y hábitos de consumo en niños y adolescentes
Authors: Meza Maya Clara Victoria Meza Maya , Lobo Ojeda Sandra Marcela , Uscátegui Maldonado Jorge Arturo
Published: April 2024

El uso de videojuegos on-line es un fenómeno extendido en todo el mundo. Los estudios sobre su incidencia en niños y adolescentes se mueven en dos áreas de investigación: quienes encuentran en estas prácticas el desarrollo de competencias cognitivas, y quienes consideran que los videojuegos propician el retraimiento social, la competencia y las conductas adictivas. Además, se cree que se debe investigar la forma como se crean los hábitos de consumo que se originan mediante el vínculo. Se trata de observar las formas en que los niños y los adolescentes adquieren hábitos de consumo en la confluencia entre “el mundo virtual” y “el mundo real”. En este texto exponemos cómo en una plataforma virtual como Club Penguin convergen herramientas, prácticas y alicientes que crean a los consumidores del futuro mediante prácticas infantiles, según la lógica de producir para consumir.
Airbnb como urbanismo de plataforma: aspectos gerais e caminhos para uma abordagem multiescalar
Authors: Cruvinel Aline Cristina Fortunato
Published: April 2024

This article presents aspects highlighted in scientific studies on Airbnb as an expression of “platform urbanism” and indicates processes that can be observed in socio-spatial and economic dynamics stimulated by short-term rentals worldwide, aiming to formulate paths for a multi-scalar investigation. To achieve this, the article is divided into three parts. In the first part, we analyze studies on Airbnb encompassing the concept of platform urbanism and indicating the main aspects they point out. In the second part, events related to Airbnb activities in five countries (United States, Mexico, Canada, Japan, and China) are presented, gathered from newspaper news. And in the third part, four processes related to these events are listed: the complexification of the real estate system; new flows defined by digital nomadism; new arrangements in the private sector; and the expansion of vacation rental companies according to pre-existing political and economic logics.
Entropia segundo Clausius
Authors: Carvalho Regina Simplício , Carvalho Alexandre Tadeu Gomes de , Laburú Carlos Eduardo
Published: April 2024

Clausius analytically expressed the first two principles of thermodynamics and introduced the concept of entropy. Together with entropy, he worked on the concept of desegregation of the body and the influence of heat on the arrangement of particles in it. This rereading of Clausius' memoirs intends to contribute to the “quasi-macroscopic” understanding of the concept of entropy and, at the same time, to offer a didactic material with a historical approach to the subject.
Processo de Criação: diálogo com a cultura
Authors: Brito Cristiane Miryam Drumond de
Published: April 2024

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De canción de cuna a narración ilustrada: una aproximación crítico-genética al libro para niños Duerme, niño duerme
Authors: Canencio Cielo Erika Ospina , Macuada July
Published: April 2024

El presente trabajo realiza un ejercicio genético que expone algunos aspectos del proceso creativo del poema ilustrado para niños Duerme, niño, duerme; escrito por Laura Herrera ilustrado por July Macuada y editado por Ekaré Sur. Mediante el análisis de un dossier genético se describen las trasformaciones editoriales, pictóricas y textuales en la adaptación de una canción de cuna (género lírico) a un texto narrativo-visual. Postulamos que el análisis de “la marcha de la escritura” devela aspectos técnicos, como la presencia del lenguaje audiovisual en la creación de la literatura infantil, así como también las decisiones  editoriales que enmarcan la selección y/o la adaptación de los géneros narrativos por encima de los líricos. Sobre esta base se presentarán algunas hipótesis acerca de la concepción del lector modelo al que apela el texto, se expondrá el trabajo colectivo entre ilustradora, editora y escritora, y finalmente, se analizarán las transformaciones materiales y textuales para configurar una nueva versión.
O CORPO E O DESENHO EM TRÂNSITO: Processos de criação de Roberto Alencar
Authors: Dias Wagner Miranda
Published: April 2024

Este artigo investiga os percursos da composição artística do artista do corpo – teatro, dança e performance – Roberto Alencar, refletindo sobre seus processos criativos, de autoria e comunicação, observando os procedimentos que envolvem seu pensamento e sua prática na produção de sua cena, destacando as relações entre desenho e corpo. A investigação do trânsito entre linguagens inserido nos processos criativos é essencial para pensarmos criticamente sobre sistemas e redes comunicacionais contemporâneas, lançando olhares sobre a construção dos diversos objetos comunicativos que atuam em hibridização, revelando diferentes modos de ação e tessituras criativas.
Historiografia da Crítica Textual de autores brasileiros: o caso Euclides da Cunha
Authors: Fachin Phablo Roberto Marchis , Silva Suellen Carneiro da
Published: April 2024

neste artigo, apresenta-se a análise das edições críticas de Os Sertões, realizadas por Walnice Nogueira Galvão, tendo como foco: 1) o estudo crítico das quatro edições; 2) a verificação de teorias e métodos utilizados para a sua concretização; 3) a indicação de diferenças e suas implicações crítico-literárias. Tal estudo compõe projeto mais amplo, intitulado Historiografia da Crítica Textual de Autores Brasileiros, desenvolvido na Faculdade de Filosofia, Letras e Ciências Humanas da USP, no Programa de Filologia e Língua Portuguesa. Procura-se, por meio da análise de edições críticas de autores brasileiros, fazer com que o estudante de graduação entenda o processo de criação e transmissão dos textos e o relacione com o que tem sido feito no contexto literário brasileiro, ou seja, desenvolva competências acadêmicas indispensáveis para o estudante em Letras no contato com o texto literário.
A figura incógnita em Crônica da casa assassinada e suas representações nos manuscritos ficcionais "Diários de André” e “Diários de Betty”
Authors: Silva Eduardo Marinho da
Published: April 2024

Este trabalho se propõe a investigar o processo de criação de uma figura incógnita presente no romance Crônica da casa assassinada, publicado em 1959 pelo escritor mineiro Lúcio Cardoso. No plano ficcional de estruturação da obra, esta figura é responsável por resgatar e coletar diversos manuscritos deixados por dez narradores-personagens, rearranjando-os de forma a orquestrar as vozes narrativas que compõem o romance. Estas narrativas, espécie de “manuscritos ficcionais” – expressão empregada por Júlio Castañon Guimarães, que realizou o estabelecimento do texto para a edição crítica do romance – são compostas por cartas, diários, depoimentos, memória e narrativas. Anônima e sem voz, a figura incógnita deixa dois tipos de marcas nos manuscritos ficcionais: a supressão de partes, indicadas por pontilhados, e as notações que apontam para as condições materiais da obra (indicados como “escritos à margem...”). A partir do cotejo do texto estabelecido com as variantes do romance, este artigo objetiva discutir as representações desta figura incógnita nos diários de Betty e de André, nos quais se encontram notações que apontam para a materialidade dos manuscritos ficcionais e os efeitos de sentido que os escritos à margem suscitam no leitor e na estrutura do romance.
Lúcio Cardoso e a coluna "O crime do dia"
Authors: Santos Cássia dos
Published: April 2024

De abril de 1952 a julho de 1953, o escritor Lúcio Cardoso trabalhou na redação do jornal vespertino A Noite, assinando uma coluna de contos de temática policial denominada “O crime do dia”. Entre os mais de 200 textos que produziu para a coluna nesse período, o autor compôs muitos que dialogavam com temas e questões existentes nos livros que publicara até então, retomando algumas de suas conhecidas obsessões. O que mais chama a atenção nesse material, no entanto, é um conjunto de contos com os quais ele parece ter ensaiado a criação de cenas e personagens dos seus futuros romances: a Crônica da casa assassinada, de 1959, e O viajante, de 1973. O objetivo deste artigo é apresentar alguns desses contos ao leitor.
O método concreto de Max Bill: conexões entre o racional e o intuitivo
Authors: Pereira Tania Calovi
Published: April 2024

Através de sua arte e arquitetura o suiço Max Bill propõe uma relação interdisciplinar baseada na razão, e que se desenvolve a partir da investigação do conceitual ao invés do formal. Depois de sair da Bauhaus em 1929, as obras de arte e edificios que ele produziu demonstram conceitos inter-relacionados, realizados com mínima forma e desafiando categorizações estilísticas. Este artigo propõe um exame na obra de Max Bill, e de seu singular processo de projeto.
Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro
Authors: Selvarajan Ilakya , Kiema Miika , Huang Ru-Ting , Li Jin , Zhu Jiayu , Pölönen Petri , Örd Tiit , Õunap Kadri , Godiwala Mehvash , Golebiewski Anna Kathryn , Ravindran Aarthi , Mäklin Kiira , Toropainen Anu , Stolze Lindsey K. , Arce Maximiliano , Magnusson Peetra U. , White Stephen , Romanoski Casey E. , Heinäniemi Merja , Laakkonen Johanna P. , Fang Yun , Kaikkonen Minna U.
Published: April 2024

BACKGROUND:

CALCRL (calcitonin receptor-like) protein is an important mediator of the endothelial fluid shear stress response, which is associated with the genetic risk of coronary artery disease. In this study, we functionally characterized the noncoding regulatory elements carrying coronary artery disease that risks single-nucleotide polymorphisms and studied their role in the regulation of
CALCRL
expression in endothelial cells.

METHODS:

To functionally characterize the coronary artery disease single-nucleotide polymorphisms harbored around the gene
CALCRL
, we applied an integrative approach encompassing statistical, transcriptional (RNA-seq), and epigenetic (ATAC-seq [transposase-accessible chromatin with sequencing], chromatin immunoprecipitation assay-quantitative polymerase chain reaction, and electromobility shift assay) analyses, alongside luciferase reporter assays, and targeted gene and enhancer perturbations (siRNA and clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeat–associated 9) in human aortic endothelial cells.

RESULTS:

We demonstrate that the regulatory element harboring rs880890 exhibits high enhancer activity and shows significant allelic bias. The A allele was favored over the G allele, particularly under shear stress conditions, mediated through alterations in the HSF1 (heat shock factor 1) motif and binding. CRISPR deletion of rs880890 enhancer resulted in downregulation of
CALCRL
expression, whereas HSF1 knockdown resulted in a significant decrease in rs880890-enhancer activity and
CALCRL
expression. A significant decrease in HSF1 binding to the enhancer region in endothelial cells was observed under disturbed flow compared with unidirectional flow.
CALCRL
knockdown and variant perturbation experiments indicated the role of CALCRL in mediating eNOS (endothelial nitric oxide synthase), APLN (apelin), angiopoietin, prostaglandins, and EDN1 (endothelin-1) signaling pathways leading to a decrease in cell proliferation, tube formation, and NO production.

CONCLUSIONS:

Overall, our results demonstrate the existence of an endothelial-specific HSF (heat shock factor)–regulated transcriptional enhancer that mediates
CALCRL
expression. A better understanding of
CALCRL
gene regulation and the role of single-nucleotide polymorphisms in the modulation of
CALCRL
expression could provide important steps toward understanding the genetic regulation of shear stress signaling responses.
Endothelial Cell Flow–Mediated Quiescence Is Temporally Regulated and Utilizes the Cell Cycle Inhibitor p27
Authors: Tanke Natalie T. , Liu Ziqing , Gore Michaelanthony T. , Bougaran Pauline , Linares Mary B. , Marvin Allison , Sharma Arya , Oatley Morgan , Yu Tianji , Quigley Kaitlyn , Vest Sarah , Cook Jeanette Gowen , Bautch Victoria L.
Published: April 2024

BACKGROUND:

Endothelial cells regulate their cell cycle as blood vessels remodel and transition to quiescence downstream of blood flow–induced mechanotransduction. Laminar blood flow leads to quiescence, but how flow-mediated quiescence is established and maintained is poorly understood.

METHODS:

Primary human endothelial cells were exposed to laminar flow regimens and gene expression manipulations, and quiescence depth was analyzed via time-to-cell cycle reentry after flow cessation. Mouse and zebrafish endothelial expression patterns were examined via scRNA-seq (single-cell RNA sequencing) analysis, and mutant or morphant fish lacking p27 were analyzed for endothelial cell cycle regulation and in vivo cellular behaviors.

RESULTS:

Arterial flow–exposed endothelial cells had a distinct transcriptome, and they first entered a deep quiescence, then transitioned to shallow quiescence under homeostatic maintenance conditions. In contrast, venous flow–exposed endothelial cells entered deep quiescence early that did not change with homeostasis. The cell cycle inhibitor p27 (
CDKN1B
) was required to establish endothelial flow–mediated quiescence, and expression levels positively correlated with quiescence depth. p27 loss in vivo led to endothelial cell cycle upregulation and ectopic sprouting, consistent with loss of quiescence. HES1 and ID3, transcriptional repressors of p27 upregulated by arterial flow, were required for quiescence depth changes and the reduced p27 levels associated with shallow quiescence.

CONCLUSIONS:

Endothelial cell flow–mediated quiescence has unique properties and temporal regulation of quiescence depth that depends on the flow stimulus. These findings are consistent with a model whereby flow-mediated endothelial cell quiescence depth is temporally regulated downstream of p27 transcriptional regulation by HES1 and ID3. The findings are important in understanding endothelial cell quiescence misregulation that leads to vascular dysfunction and disease.
Linking the neural signature of response time variability to Alzheimer’s disease pathology and cognitive functioning
Authors: Teng James , McKenna Michael R. , Gbadeyan Oyetunde , Prakash Ruchika S. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: April 2024

Promising evidence has suggested potential links between mind-wandering and Alzheimer’s disease (AD). Yet, older adults with diagnosable neurocognitive disorders show reduced meta-awareness, thus questioning the validity of probe-assessed mind-wandering in older adults. In prior work, we employed response time variability as an objective, albeit indirect, marker of mind-wandering to identify patterns of functional connectivity that predicted mind-wandering. In the current study, we evaluated the association of this connectome-based, mind-wandering model with cerebral spinal fluid (CSF) p-tau/Aβ42 ratio in 289 older adults from the Alzheimer’s Disease NeuroImaging Initiative (ADNI). Moreover, we examined if this model was similarly associated with individual differences in composite measures of global cognition, episodic memory, and executive functioning. Edges from the high response time variability model were significantly associated with CSF p-tau/Aβ ratio. Furthermore, connectivity strength within edges associated with high response time variability was negatively associated with global cognition and episodic memory functioning. This study provides the first empirical support for a link between an objective neuromarker of mind-wandering and AD pathophysiology. Given the observed association between mind-wandering and cognitive functioning in older adults, interventions targeted at reducing mind-wandering, particularly before the onset of AD pathogenesis, may make a significant contribution to the prevention of AD-related cognitive decline.
Distinguishing Impacts on Winter Temperatures in Northern Mid–High-Latitude Continents during Multiyear and Single-Year La Niña Events: A Modeling Study
Authors: Zhu Tingting , Yu Jin-Yi
Published: April 2024

Utilizing a 2200-yr CESM1 preindustrial simulation, this study examines the influence of property distinctions between single-year (SY) and multiyear (MY) La Niñas on their respective impacts on winter surface air temperatures across mid–high-latitude continents in the model, focusing on specific teleconnection mechanisms. Distinct impacts were identified in four continent sectors: North America, Europe, Western Siberia (W-Siberia), and Eastern Siberia (E-Siberia). The typical impacts of simulated SY La Niña events are featured with anomalous warming over Europe and W&E-Siberia and anomalous cooling over North America. Simulated MY La Niña events reduce the typical anomalous cooling over North America and the typical anomalous warming over W&E-Siberia but intensify the typical anomalous warming over Europe. The distinct impacts of simulated MY La Niñas are more prominent during their first winter than during the second winter, except over W-Siberia, where the distinct impact is more pronounced during the second winter. These overall distinct impacts in the CESM1 simulation can be attributed to the varying sensitivities of these continent sectors to the differences between MY and SY La Niñas in their intensity, location, and induced sea surface temperature anomalies in the Atlantic Ocean. These property differences were linked to the distinct climate impacts through the Pacific North America, North Atlantic Oscillation, Indian Ocean–induced wave train, and tropical North Atlantic–induced wave train mechanisms. The modeling results are then validated against observations from 1900 to 2022 to identify disparities in the CESM1 simulation.