bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving UK data on avoidable perinatal brain injury: review of data dictionaries and consultation
Authors: van der Scheer Jan W. , Komolafe Victoria , Webster Kirstin , Iliodromiti Stamatina , Roehr Charles C. , Khalil Asma , Draycott Tim , Dewick Louise , Dunn George , Walsh Rachel , Steer Philip , Giusti Alessandra , Cabling Mark L. , Fahy Nick ,   ABC Contributor Group, Frémeaux Alissa E. , Karia Amar M. , Anderson Annette , Leigh Bertie , Gale Chris , Doherty Cora , Wolstenholme Daniel , Walker James , Gudgeon Julia , Cowell Laura , Knight Marian , Jolly Matthew C. , Wahedally Muhammed Ally Hussein , van Hasselt Tim J. , Harris Tina , Dixon-Woods Mary
Published: January 2025

Background

High quality data is important to understanding epidemiology and supporting improvement efforts in perinatal brain injury. It is not clear which data items relevant to brain injury are captured across UK sources of routinely collected data, nor what needs to be done to ensure that those sources are fit for purpose in improving care.

Methods

We reviewed data dictionaries of four main UK perinatal data sources and consulted a multi-professional group (N = 27) with expertise in neonatal/maternity care, statistics, and clinical negligence.

Results

None of the data sources we reviewed currently captures, on its own, the range of items relevant to brain injury. Data items lack common definitions and ongoing linkage across the different sources. Our consultation identified the need for standardising the definition of avoidable perinatal brain injury, resolving inconsistencies in capturing data, improving linkage of data across existing data sources, and co-designing a strategy for meaningful use of data.

Conclusions

Limited standardisation and linkage across UK data sources are key problems in using data to guide improvement efforts aimed at reducing risk of avoidable perinatal brain injury. A programme involving co-design with healthcare professionals and families to improve capture and use of data is now needed.

Impact

Limited standardisation and linkage across UK data sources currently challenge the use of data as the basis of efforts to reduce risk of avoidable perinatal brain injury.

A harmonisation programme involving consultation and co-design with healthcare professionals, families, and other specialists is needed to enable better capture and use of data in this key area.

There is need to standardise the definition of avoidable perinatal brain injury, resolve inconsistencies in capturing data, improve linkage of data collected across existing data sources, and co-design a strategy for meaningful use of data.
Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemia
Authors: Chen Yu-jun , Zhao Yu , Yao Ming-yue , Wang Ya-fang , Ma Ming , Yu Cheng-cheng , Jiang Hua-liang , Wei Wu , Shen Jie , Xu Xiao-wei , Xie Cheng-ying
Published: January 2025

FMS-like tyrosine kinase-3 (FLT3), a class 3 receptor tyrosine kinase, can be activated by mutations of internal tandem duplication (FLT3-ITD) or point mutations in the tyrosine kinase domain (FLT3-TKD), leading to constitutive activation of downstream signaling cascades, including the JAK/STAT5, PI3K/AKT/mTOR and RAS/MAPK pathways, which promote the progression of leukemic cells. Despite the initial promise of FLT3 inhibitors, the discouraging outcomes in the treatment of FLT3-ITD-positive acute myeloid leukemia (AML) promote the pursuit of more potent and enduring therapeutic approaches. The histone acetyltransferase complex comprising the E1A binding protein P300 and its paralog CREB-binding protein (p300/CBP) is a promising therapeutic target, but the development of effective p300/CBP inhibitors faces challenges due to inherent resistance and low efficacy, often exacerbated by the absence of reliable clinical biomarkers for patient stratification. In this study we investigated the role of p300/CBP in FLT3-ITD AML and evaluated the therapeutic potential of targeting p300/CBP alone or in combination with FLT3 inhibitors. We showed that high expression of p300 was significantly associated with poor prognosis in AML patients and positively correlated with FLT3 expression. We unveiled that the p300/CBP inhibitors A485 or CCS1477 dose-dependently downregulated FLT3 transcription via abrogation of histone acetylation in FLT3-ITD AML cells; in contrast, the FLT3 inhibitor quizartinib reduced the level of H3K27Ac. Concurrent inhibition of p300/CBP and FLT3 enhanced the suppression of FLT3 signaling and H3K27 acetylation, concomitantly reducing the phosphorylation of STAT5, AKT, ERK and the expression of c-Myc, thereby leading to synergistic antileukemic effects both in vitro and in vivo. Moreover, we found that p300/CBP-associated transcripts were highly expressed in quizartinib-resistant AML cells with FLT3-TKD mutation. Targeting p300/CBP with A485 or CCS1477 retained the efficacy of quizartinib, suggesting marked synergy when combined with p300/CBP inhibitors in quizartinib-resistant AML models, as well as primary FLT3-ITD+ AML samples. These results demonstrate a potential therapeutic strategy of combining p300/CBP and FLT3 inhibitors to treat FLT3-ITD and FLT3-TKD AML.
SEC-MX: an approach to systematically study the interplay between protein assembly states and phosphorylation
Authors: Doron-Mandel Ella , Bokor Benjamin J. , Ma Yanzhe , Street Lena A. , Tang Lauren C. , Abdou Ahmed A. , Shah Neel H. , Rosenberger George , Jovanovic Marko
Published: January 2025

A protein’s molecular interactions and post-translational modifications (PTMs), such as phosphorylation, can be co-dependent and reciprocally co-regulate each other. Although this interplay is central for many biological processes, a systematic method to simultaneously study assembly states and PTMs from the same sample is critically missing. Here, we introduce SEC-MX (Size Exclusion Chromatography fractions MultipleXed), a global quantitative method combining Size Exclusion Chromatography and PTM-enrichment for simultaneous characterization of PTMs and assembly states. SEC-MX enhances throughput, allows phosphopeptide enrichment, and facilitates quantitative differential comparisons between biological conditions. Conducting SEC-MX on HEK293 and HCT116 cells, we generate a proof-of-concept dataset, mapping thousands of phosphopeptides and their assembly states. Our analysis reveals intricate relationships between phosphorylation events and assembly states and generates testable hypotheses for follow-up studies. Overall, we establish SEC-MX as a valuable tool for exploring protein functions and regulation beyond abundance changes.
Stress landscape of folding brain serves as a map for axonal pathfinding
Authors: Solhtalab Akbar , Foroughi Ali H. , Pierotich Lana , Razavi Mir Jalil
Published: January 2025

Understanding the mechanics linking cortical folding and brain connectivity is crucial for both healthy and abnormal brain development. Despite the importance of this relationship, existing models fail to explain how growing axon bundles navigate the stress field within a folding brain or how this bidirectional and dynamic interaction shapes the resulting surface morphologies and connectivity patterns. Here, we propose the concept of “axon reorientation” and formulate a mechanical model to uncover the dynamic multiscale mechanics of the linkages between cortical folding and connectivity development. Simulations incorporating axon bundle reorientation and stress-induced growth reveal potential mechanical mechanisms that lead to higher axon bundle density in gyri (ridges) compared to sulci (valleys). In particular, the connectivity patterning resulting from cortical folding exhibits a strong dependence on the growth rate and mechanical properties of the navigating axon bundles. Model predictions are supported by in vivo diffusion tensor imaging of the human brain.
Time-resolved compositional and dynamics analysis of biofilm maturation and dispersal via solid-state NMR spectroscopy
Authors: Xue Yi , Kang Xue
Published: January 2025

Dispersal plays a crucial role in the development and ecology of biofilms. While extensive studies focused on elucidating the molecular mechanisms governing this process, few have characterized the associated temporal changes in composition and structure. Here, we employed solid-state nuclear magnetic resonance (NMR) techniques to achieve time-resolved characterization of Bacillus subtilis biofilms over a 5-day period. The mature biofilm, established within 48 h, undergoes significant degradation in following 72 h. The steepest decline of proteins precedes that of exopolysaccharides, likely reflecting their distinct spatial distribution. Exopolysaccharide sugar units display clustered temporal patterns, suggesting the presence of distinct polysaccharide types. A sharp rise in aliphatic carbon signals on day 4 probably corresponds to a surge in biosurfactant production. Different dynamic regimes respond differently to dispersal: the mobile domain exhibits increased rigidity, while the rigid domain remains stable. These findings provide novel insights and perspectives on the complex process of biofilm dispersal.
Milk-derived extracellular vesicles and gut health
Authors: Muttiah Barathan , Law Jia Xian
Published: January 2025

Milk is a nutrient-rich liquid produced by mammals, offering various health benefits due to its composition of proteins, fats, carbohydrates, vitamins, and minerals. Beyond traditional nutritional aspects, recent research has focused on extracellular vesicles (EVs) found in milk and their potential health benefits, especially for gastrointestinal (GI) health. Milk-derived EVs have been shown to influence gut microbiota, promote gut barrier integrity, support tissue repair and regeneration, modulate immune responses, and potentially aid in managing conditions like inflammatory bowel disease (IBD) and colorectal cancer. This review discusses the current understanding of milk-EVs’ effects on gut health, highlighting their potential therapeutic applications and future research directions. These findings underscore the promising role of milk-derived EVs in advancing GI health and therapeutics, paving the way for innovative approaches in oral drug delivery and targeted treatments for GI disorders.
Subclinical patterns of cardiac involvement by transthoracic echocardiography in individuals with mild initial COVID-19
Authors: Shchendrygina Anastasia , Ka Mame Madjiguène , Rodriguez Carlos , Alsoufi Safaa , Hoffmann Jedrzej , Kumar Parveen , Carerj Maria Ludovica , Vanchin Byambasuren , Holm Niels , Karyou Argyro , Ganbat Mijidsuren , Nagel Eike , Puntmann Valentina O.
Published: January 2025

The aim of this study was to evaluate the subclinical patterns and evolution of cardiac abnormalities via transthoracic echocardiography (TTE) in patients with mild initial COVID-19 illness. A total of 343 infected individuals (163 males; age 44 (interquartile range, IQR 35–52) years) years) underwent serial TTE assessments at a median of 109 (interquartile range (IQR), 77–177) and 327 (276–379) days after infection. Compared with those of non-COVID-19-infected controls (n = 94, male n = 49), baseline systolic (LVEF, TAPSE) and diastolic function (eʹ, aʹ, E/eʹ) were significantly different in infected participants (p < 0.05 for all). Compared with baseline assessments, there was a reduction in global longitudinal strain (GLS) and an increase in the E wave, E/A ratio and E/eʹ at follow-up. At baseline, symptomatic participants had a lower LVEF and TAPSE and increased IVRT, eʹ and E/eʹ. At follow-up, symptomatic patients had a lower LV end-diastolic diameter (LVEDd). Symptoms were independently associated with E/eʹ at baseline (OR (95% CI) 1.45 (1.12–1.87), p = 0.005). Symptoms at follow-up were associated with LVEDd, measured either at baseline (OR: 0.91 (0.86, 0.96), p < 0.001) or follow-up (OR (95% CI) 0.91 (0.86–0.96), p < 0.001). There were significant associations for GLS and troponin and E/eʹ with CRP and NTproBNP at baseline. In the present cohort of COVID-19-infected individuals with mild initial illness, echocardiographic measurements revealed significant yet subclinical differences in systolic and diastolic function compared with controls, as well as between individuals with cardiac symptoms and those without. All the measured differences were small in magnitude and thus unlikely to be detectable clinically at the individual level.
Exploring the role of circulating proteins in multiple myeloma risk: a Mendelian randomization study
Authors: Lee Matthew A. , Burley Kate L. , Hazelwood Emma L. , Moore Sally , Lewis Sarah J. , Goudswaard Lucy J.
Published: January 2025

Multiple myeloma (MM) is an incurable blood cancer with unclear aetiology. Proteomics is a valuable tool in exploring mechanisms of disease. We investigated the causal relationship between circulating proteins and MM risk, using two of the largest cohorts with proteomics data to-date. We performed bidirectional two-sample Mendelian randomization (MR; forward MR = causal effect estimation of proteins and MM risk; reverse MR = causal effect estimation of MM risk and proteins). Summary statistics for plasma proteins were obtained from genome-wide association studies performed using SomaLogic (N = 35,559; deCODE) and Olink (N = 34,557; UK Biobank; UKB) proteomic platforms and for MM risk from a meta-analysis of UKB and FinnGen (case = 1649; control = 727,247) or FinnGen only (case = 1085; control = 271,463). Cis-SNPs associated with protein levels were used to instrument circulating proteins. We evaluated proteins for the consistency of directions of effect across MR analyses (with 95% confidence intervals not overlapping the null) and corroborating evidence from genetic colocalization. In the forward MR, 994 (SomaLogic) and 1570 (Olink) proteins were instrumentable. 440 proteins were analysed in both deCODE and UKB; 302 (69%) of these showed consistent directions of effect in the forward MR. Seven proteins had 95% confidence intervals (CIs) that did not overlap the null in both forward MR analyses and did not have evidence for an effect in the reverse direction: higher levels of dermatopontin (DPT), beta-crystallin B1 (CRYBB1), interleukin-18-binding protein (IL18BP) and vascular endothelial growth factor receptor 2 (KDR) and lower levels of odorant-binding protein 2b (OBP2B), glutamate-cysteine ligase regulatory subunit (GCLM) and gamma-crystallin D (CRYGD) were implicated in increasing MM risk. Evidence from genetic colocalization did not meet our threshold for a shared causal signal between any of these proteins and MM risk (h4 < 0.8). Our results highlight seven circulating proteins which may be involved in MM risk. Although evidence from genetic colocalization suggests these associations may not be robust to the effects of horizontal pleiotropy, these proteins may be useful markers of MM risk. Future work should explore the utility of these proteins in disease prediction or prevention using proteomic data from patients with MM or precursor conditions.
Cost-efficient behavioral modeling of antennas by means of global sensitivity analysis and dimensionality reduction
Authors: Koziel Slawomir , Pietrenko-Dabrowska Anna
Published: January 2025

Computational tools, particularly electromagnetic (EM) solvers, are now commonplace in antenna design. While ensuring reliability, EM simulations are time-consuming, leading to high costs associated with EM-driven procedures like parametric optimization or statistical design. Various techniques have been developed to address this issue, with surrogate modeling methods garnering particular attention due to their potential advantages. One key benefit is the promise of unprecedented acceleration in handling design problems that require repetitive system evaluations. However, behavioral modeling of antennas is an intrinsic endeavor. Challenges include the curse of dimensionality and the high nonlinearity of antenna characteristics. Moreover, design utility necessitates that the models are defined across wide ranges of frequency, geometry dimensions, and material parameters, posing a significant bottleneck for existing modeling frameworks. This paper introduces an innovative approach to constructing design-ready behavioral surrogates for antenna structures. Our methodology involves a rapid global sensitivity analysis (GSA) algorithm developed to determine a set of parameter space directions that maximize antenna response variability. The latter are obtained from spectral analysis of the GSA-based sensitivity indicators, and employed to define a reduced-dimensionality domain of the metamodel. The dependability of the model constructed in such a domain is superior over conventional surrogates while being suitable for design purposes. These benefits have been conclusively showcased using several microstrip antennas and illustrated by a number of design scenarios involving antenna geometry optimization for a variety of performance specifications.
The nucleation and growth mechanism of spherical Li for advanced Li metal anodes – a review
Authors: Wang Mengting , Guo Xingtong , Luo Rui , Jiang Xiaonuo , Tang Yongfu , Wei Tao
Published: January 2025

This review systematically depicts the theoretical models for Li deposition, the mechanisms and formation conditions of spherical Li and the advantages of combining Li spheres with 3D conductive frameworks.
Development of diselenide-based fluorogenic system for the selective and sensitive detection of the Hg(ii) in aqueous media
Authors: Malankar Gauri S. , Shelar Divyesh S. , Butcher Ray J. , Manjare Sudesh T.
Published: January 2025

This is rhodamine-based diselenide containing fluorogenic probe. The probe selectively identifies Hg(ii) in nanomolar range. The probe sensitively detected Hg(ii) in human prostate cancer cell line, C4-2.
Advanced carbon-based rear electrodes for low-cost and efficient perovskite solar cells
Authors: He Jingsheng , Bai Yu , Luo Zhixin , Ran Ran , Zhou Wei , Wang Wei , Shao Zongping
Published: January 2025

This article reviews important advances in the design and fabrication of carbon-based rear electrodes for perovskite solar cells, aiming to present vital insights for the scalable production and widespread applications of this technology.
Recent advances in ex ante techno-environmental-economic assessment of thermochemical waste or biomass to energy technologies based on process simulation
Authors: Tang Jiehong , Tang Yuting , Liu Hongyu , Chen Xinfei , Zhang Xikui , Chen Yin , Liang Shuang , Huang Junxuan , Teng Wen , Sun Ziwei , Ma Xiaoqian
Published: January 2025

The based ex-ante techno-environmental-economic assessment based on process simulation can predict the performance based on the exiting laboratory- or pilot-scale experiment results and provide multidimensional quantified guidance.
Design, Synthesis and Evaluation of Pyrimidinobenzylamide and Pyrimidinothiophenamide Derivatives as Inhibitors of DOT1L and Related Epigenetic Targets DNMT3a, PRMT4 and other HMTs
Authors: Castillo-Aguilera Oscar Omar , Depreux Patrick , Halby Ludovic , Bailly Christian , Domínguez-Ramírez Lenin , Gul Sheraz , Arimondo Paola B. , Goossens Laurence
Published: January 2025

The histone methyltransferase DOT1L (DOT1 like, disruptor of telomeric silencing) is responsible of methylation of H3K79, leading to oncogene transcription, and its involved in the development of different types of...
Discovery of selective, metabolically stable pyrazole-based FLT3 inhibitors for the treatment of acute myeloid leukemia
Authors: Destro Lorenza , Crippa Valentina , Gabbia Daniela , Roverso Marco , Bogialli Sara , Zardi Paolo , Marzaro Giovanni , Mologni Luca , Zambon Alfonso
Published: January 2025

A narrow selectivity profile, limited metabolism and a reliable SAR suggest the little explored biphenyl pyrazoyl-urea scaffold as a promising chemotype for the development of FLT3-targeting drugs for the treatment of AML.
Reassessing mechanochemical processes in polyatomic systems for smart fabrication of nanocomposites
Authors: Senna Mamoru , Michalchuk Adam A. L.
Published: January 2025

Issues around mechanochemistry were integrated from the molecular deformation to material synthesis under mechanical stressing, with the key concept of the reactivity of solids.
Graphene quantum dots as potential broad-spectrum antiviral agents
Authors: Jung Younghun , Hwang Jaehyeon , Cho Hyeonwoo , Yoon Jeong Hyeon , Lee Jong-Hwan , Song Jaekwang , Kim Donghoon , Ahn Minchul , Hong Byung Hee , Kweon Dae-Hyuk
Published: January 2025

Graphene quantum dots (GQDs) are proposed as potential broad-spectrum antiviral agents as their amphiphilic properties could destroy viral membranes, regardless of the type of viruses, including SARS-CoV-2 and influenza virus.
Highly efficient synthesis of furan-2-ylmethylboranes by a copper-catalyzed three-component cascade strategy
Authors: Hang Chengrui , Lu Fei , Song Daan , Wang Guanghui , Zhao Ximei
Published: January 2025

The copper-catalyzed three-component Knoevenagel condensation/enynone cyclization/B–H bond insertion cascade offers a concise and highly efficient one-step access to furan-2-ylmethylboranes.
Layered magnesium oxide for efficient removal of fluoride from groundwater
Authors: Shi Ling , Zhao Shiling , Wang Xixi , He Jiali , Zhao Yu , Wang Kaizhi
Published: January 2025

This study presents a novel layered magnesium oxide (MgO) adsorbent synthesized using a sodium dodecylbenzene sulfonate (SDBS)-assisted hydrothermal method aimed at enhancing fluoride removal from water.
Intense, self-induced sustainable microwave plasma using carbon nanotubes made from CO2
Authors: Licht Gad , Hofstetter Kyle , Licht Stuart
Published: January 2025

An intense new energy source is triggered by carbon captured carbon nanotubes.
A charge-assisted hydrogen-bonded organic framework as a host platform for enzyme immobilization and robust biocatalysis
Authors: Xu Jie , Zuo Mengxuan , Zhang Hanyuan , Di Zhengyi , Li Cheng-Peng
Published: January 2025

A charge-assisted HOF scaffold, assembled from two trigonal building blocks, can protect the catalase and α-amylase enzymes from degradation while maintaining their activity under harsh chemical and physical conditions.
Palladium-catalyzed Catellani-type selective C–H silylation of aryl-TT salts
Authors: Tang Ziyao , Guan Mangang , Wang Tianqiang , Yu Guojun , Qin Jiaze , Lan Jingfeng , Yan Rulong
Published: January 2025

A palladium-catalyzed three-component reaction of aryl-thianthrenium salts, norbornene/diphenylacetylene and hexamethyldisilane has been developed for the assembly of functionalized disilanes through C–C bond and C–Si bonds formation.
Direct C1 homologation of carboxylic acids: free radical approach enabled by acridine catalysis
Authors: Rubanov Zakhar M. , Levin Vitalij V. , Dilman Alexander D.
Published: January 2025

Homologation of carboxylic acids with a tosylhydrazone reagent is described. The reaction is performed using a dual acridine/decatungstate photocatalytic system.
Unraveling the role of a Cu dopant in formaldehyde catalytic oxidation over a La0.8Sr0.2Mn1−xCuxO3 perovskite: an experimental and theoretical study
Authors: Ding Junyan , Zhao Liming , Yang Yingju , Liu Jing
Published: January 2025

A series of La0.8Sr0.2Mn1−xCuxO3 perovskite-type catalysts were prepared through a sol–gel method and evaluated for formaldehyde catalytic oxidation.
Machine-learning guided discovery of ultralow-threshold organic gain materials towards electrically pumped lasing
Authors: Zhang Yueting , Zheng Haofeng , Dong Zhen , Liu Yanan , Liu Qi , Xiao Jin , Wang Yanlong , Pang Shuai , Ma Xuyu , Liao Qing , Hou Shaocong
Published: January 2025

Machine learning is demonstrated for discovering ultralow-threshold organic gain molecules with an ASE threshold of approximately 0.011 μJ cm−2, satisfying the requirement (0.1 kA cm−2) for electrically pumped lasers.
A focus on a complex abiotic tertiary structure
Authors: Zhong Yulong , Gong Bing
Published: January 2025

This article highlights the recent report of Wang et al. (Chem. Sci., 2025, https://doi.org/10.1039/D4SC07336C) on the successful creation of a complex abiotic tertiary structure based on the covalent connection of the molecular components of a known quaternary structure of helical foldamers.
A detailed investigation on the mechanical properties and sensitisation resistance of cyclic strengthened AA5083 alloy
Authors: Zhang Kai , Xia Xiaojian , Meng Ya , Zeng Guang , Zhang Ruifeng
Published: January 2025

A new Cyclic strengthening (CS) method was applied to the AA5083 alloy. The influence of this new method on mechanical properties and sensitisation were both studied. The CS treatment significantly increases the strength by inducing dislocations and Mg clusters. These clusters then weaken the grain boundary β‐phase precipitation during sensitisation, thus enhancing the corrosion resistance. A further inspection on the post corrosion morphology of the sensitised cyclic strengthened AA5083 was conducted by scanning microscopy and synchrotron X‐ray tomography, suggesting that the corrosion behaviour of cyclic strengthened AA5083 has no significant difference with the water quenched AA5083.
A review of the effect of common fault current limiters (FCLs) on power systems reliability
Authors: Esmaeili Zahra , Heydari Hossein
Published: January 2025

Short‐circuit (SC) current poses a significant threat to power system stability. A fault current limiter (FCL) serves as an effective tool for restricting fault currents. This review article aims to explore the impact of FCLs on power system reliability. To achieve this, it examines existing studies on the influence of FCLs on the reliability of various systems, including substations and distribution networks. It highlights research gaps and challenges within this domain. Based on the identified gaps, it offers recommendations for future research to scholars. This review article provides a solid foundation for researchers engaged in the FCL domain and the reliability of power systems.
Adaptive power management for multiaccess edge computing‐based 6G‐inspired massive Internet of Things
Authors: Awoyemi Babatunde S. , Maharaj Bodhaswar T.
Published: January 2025

Multiaccess edge computing (MEC) is a dynamic approach for addressing the capacity and ultra‐latency demands caused by the pervasive growth of real‐time applications in next‐generation (xG) wireless communication networks. Powerful computational resource‐enriched virtual machines (VMs) are used in MEC to provide outstanding solutions. However, a major challenge with using VMs in xG networks is the high overhead caused by the excessive energy demands of VMs. To address this challenge, containers, which are generally more energy‐efficient and less computationally demanding, are being advocated. This paper proposes a containerised edge computing model for power optimisation in 6G‐inspired massive Internet‐of‐Things applications. The problem is formulated as a central processing unit energy consumption cost function based on quasi‐finite system observations. To achieve practicable computational complexity, an approach that uses a search heuristic based on Lyapunov techniques is employed to obtain near‐optimal solutions. Important performance metrics are successfully predicted using the online look‐ahead technique. The predictive model used achieves an accuracy of 97% prediction compared to actual data. To further improve resource demand, an adaptive controller is used to schedule computational resources on a time slot basis in an adaptive manner while continuing to receive workload levels to plan future resource provisioning. The proposed technique is shown to perform better compared to a competitive baseline algorithm.
Simulating realistic self-interacting dark matter models including small and large-angle scattering
Authors: Arido Cenanda , Fischer Moritz S. , Garny Mathias
Published: January 2025

Context. Dark matter (DM) self-interactions alter matter distribution on galactic scales and alleviate tensions with observations. A feature of the self-interaction cross section is its angular dependence, which influences offsets between galaxies and DM halos in merging galaxy clusters. While algorithms for modelling mostly forward-dominated or mostly large-angle scatterings exist, incorporating realistic angular dependencies within N-body simulations remains challenging.

Aims. To efficiently simulate models with a realistic angle dependence, such as light mediator models, we developed, validated, and applied a novel method.

Methods. We combined existing approaches to describe small- and large-angle scattering regimes within a hybrid scheme. Below a critical angle, the scheme uses the effective description of small-angle scattering via a drag force combined with transverse momentum diffusion, while above the angle, it samples the dependence explicitly.

Results. We first verified the scheme using a test set-up with known analytical solutions, and we checked that our results are insensitive to the choice of the critical angle within an expected range. Next, we demonstrated that our scheme speeds up the computations by multiple orders of magnitude for realistic light mediator models. Finally, we applied the method to galaxy cluster mergers. We discuss the sensitivity of the offset between galaxies and DM to the angle dependence of the cross section. Our scheme ensures accurate offsets for mediator mass mϕ and DM mass mχ within the range 0.1v/c ≲ mϕ/mχ ≲ v/c, while for larger (smaller) mass ratios, the offsets obtained for isotropic (forward-dominated) self-scattering are approached. Here, v is the typical velocity scale. Equivalently, the upper condition can be expressed as $ 1.1\lesssim \sigma_{\mathrm{tot}}/\sigma_{\mathrm{\widetilde{T}}}\lesssim 10 $ for the ratio of the total and momentum transfer cross sections, with the ratio being 1 (∞) in the isotropic (forward-dominated) limits.
SN 2023ixf: An average-energy explosion with circumstellar medium and a precursor
Authors: Kozyreva Alexandra , Caputo Andrea , Baklanov Petr , Mironov Alexey , Janka Hans-Thomas
Published: January 2025

The fortunate proximity of the Type II supernova (SN) 2023ixf has allowed astronomers to follow its evolution from almost the moment of the collapse of the progenitor’s core. SN 2023ixf can be explained as an explosion of a massive star with an energy of 0.7 × 1051 erg but with a greatly reduced envelope mass, probably because of binary interaction. In our radiative-transfer simulations, the SN ejecta of 6 M⊙ interact with circumstellar matter (CSM) of (0.55–0.83) M⊙ extending to 1015 cm, which results in a light curve (LC) peak matching that of SN 2023ixf. The origin of this required CSM might be gravity waves originating from convective shell burning, which could enhance wind-like mass loss during the late stages of stellar evolution. The steeply rising low-luminosity flux during the first hours after observationally confirmed non-detection, however, cannot be explained by the collision of the energetic SN shock with the CSM. Instead, we consider it as a precursor that we can fit by the emission from (0.5–0.9) M⊙ of matter that was ejected with an energy of ∼1049 erg a fraction of a day before the main shock of the SN explosion reached the surface of the progenitor. The source of this energy injection into the outermost shell of the stellar envelope could also be dynamical processes related to the convective activity in the progenitor’s interior or envelope. Alternatively, the early rise of the LC could point to the initial breakout of a highly non-spherical SN shock or of fast-moving asymmetrically ejected matter that was swept out well ahead of the SN shock, potentially in a low-energy, nearly relativistic jet. We also discuss that pre-SN outbursts and LC precursors can be used to study or to constrain energy deposition in the outermost stellar layers by the decay of exotic particles, such as axions, which could be produced simultaneously with neutrinos in the newly formed hot neutron star. A careful analysis of the earliest few hours of the LCs of SNe can reveal elusive precursors and provide a unique window onto the surface activity of massive stars during their core collapse. This can greatly improve our understanding of stellar physics and consequently also offer new tools for searching for exotic particles.
Characteristics of sediment in the intertidal zone of the west coast waters of Aceh Besar
Authors: Fitriah Nanda , Irham Muhammad , Dewiyanti Irma
Published: January 2025

Aceh Besar west coast is one of the beaches on the west coast of Aceh Besar Regency located in Aceh Province, the tip of Sumatra Island, Indonesia. In the intertidal zone of the west coast there are many human activities such as tourism, industry, and fisheries. The purpose of this study is to determine the characteristics of sediments including the physical and chemical of sediments in the intertidal zone of the west coast of Aceh Besar. The method used in this study is a survey method, which is carried out in the field directly to collect the data and samples. Samples were analyzed in the laboratory to determine the texture of sediment and its percentage. Sediment texture found in the intertidal zone of the west coast of Aceh Besar are sand and sandy loam. The sediment fraction is dominated by the sand fraction with a percentage of 81-90%. The content of organic carbon in the sediment is in the low category. The salinity value of the sediment shows high salinity results and the pH value of the sediment in the intertidal zone shows an alkaline pH category at each research station.
Estimation of aboveground biomass and carbon storage in mangroves along the coast of Banda Aceh City
Authors: Farahisah Harum , Nanda Muhammad , Haditiar Yudi , Khairunnisa
Published: January 2025

One of the ecosystem services provided by mangroves is carbon absorption and storage, known as blue carbon. The coastal area of Banda Aceh has significant potential for mangrove forests as carbon stocks. This study aimed to estimate the carbon storage in mangrove vegetation along the Banda Aceh coast. The objectives were to calculate the density, aboveground biomass, and carbon storage of mangroves in this area. Data collection was conducted at four stations, namely Station 1 in Meuraxa District, Station 2 in Kuta Raja District, Station 3 in Kuta Alam District, and Station 4 in Syiah Kuala District, using a 100 m² quadrat transect method. Data processing involved allometric equations to determine aboveground biomass and carbon storage. Three mangrove species were identified: Rhizophora mucronata, Avicennia marina, and Nypa fruticans. The average mangrove density at Stations 1, 2, 3, and 4 was 0.50/m², 0.18/m², 0.17/m², and 0.32/m², respectively. The average aboveground biomass and carbon storage in the coastal area of Banda Aceh were 1450.18 kg/100 m² and 68.16 tons of carbon per hectare. This study underscores the potential of mangroves along the Banda Aceh coastline as carbon sinks, contributing to climate change mitigation.
Checklist of native and invasive fishes in Aneuk Laot Lake, Sabang, Indonesia
Authors: Nurfadillah Nurfadillah , Fadli Nur , Jalil Zulkarnain , Adelyna Mohammed Akib Noor , Madewi Lis
Published: January 2025

Identification of native and invasive fish species helps in effective management of aquatic resources, including fisheries regulation, habitat restoration, and conservation. The objective of the study is to identify the native and invasive fish species found in the waters of Aneuk Laot Lake, Kota Sabang. This research was conducted from March to May 2024 in the waters of Aneuk Laot Lake. Sampling was carried out directly (sweaping) using nets measuring 1/2 inch, 3/4 inch and 1 inch. The types of fish caught in the waters of Aneuk Laot Lake consist of 4 orders, namely Cypriniformes, Cichliformes, Anabantiformes and Cyprinodontiformes. The composition of fish species in the waters of Aneuk Laot Lake, Sabang City, was identified as 6 species, namely the presence of native fish groups (native species) and invasive species. The native lake fish caught are Barbodes sp. and Rasbora sp. while the invasive fish species are Amphilophus trimaculatus, Oreochromis niloticus, Channa striata and Gambusia affinis. The diversity of fish species is useful for the management and conservation of biological resources in Aneuk Laot Lake, which is very important for the ecosystem and community of Aneuk Laot Lake, Sabang City.
Evaluation of formalin in salted fish in the main market of Lambaro and Ketapang Aceh Besar
Authors: Twentyna Dolorosa Maretty , Fauzan Lubis Ahmad , Pahala Sitanggang Lucien , Faidillah Fitra , Julia Mizulni Putri
Published: January 2025

Salted fish is one of the favorite local fisheries processed foods by the Indonesian people, where the product is made through a preservation process using salt. The addition of prohibited preservatives such as formalin is still found, this is thought to be due to a lack of knowledge from artisanal fishers about salted fish processing that is safe for consumption. This research aims to determine the formalin content of salted fish in Lambaro Main Market and Ketapang and the distribution pattern of salted fish sales in the Aceh Besar Market. The formalin test was conducted qualitatively using a formalin kit with two repetitions. Data analysis was conducted descriptively. The results showed that three samples were positive for formalin at 38% in Lambaro Main Market (1st and 2nd repetition). While in Ketapang Market, there were two and three formalin positive samples (1st and 2nd repetition) at 29% and 43%, respectively. The distribution pattern of salted fish sales in Aceh Besar Market is very short, namely producers sell to collectors, then to traders in Lambaro and Ketapang Market, and forwarder to consumers. The salted fish producers come from Medan (North Sumatra), Meulaboh (West Aceh) and Blang Pidie (Southwest Aceh).
Distribution of fishing grounds of longline sharks based in Ujung Serangga Fishing Base, Southwest Aceh, Aceh
Authors: Rahmah Alvi , Aprilla Ratna Mutia , Dwi Okta Rosi , Fathanah Yusuf
Published: January 2025

The number and size of shark catches at Ujung Serangga Fish Landing Base have declined, while the operational area of shark longlines has expanded since 2015. This research aims to determine the distribution of longline fishing grounds and the composition of the shark catches for longlines based in Ujung Serangga Fish Landing Base. This research was done in 2024, March to April at Ujong Serangga Fish Landing Base, Padang Baru Village, Susoh District, Southwest Aceh Regency. The research method is descriptive. The results showed that shark catches were most common in the Mentawai waters of Siberut Island and Pagai Island. During the research, sharks landed at Ujung Serangga Fish Landing Base totaling 296 individuals with a total of 8 species. The dominant shark during the study was the lanjaman shark (Carcharhinus falciformis) with a total of 147 individuals (49.66%) and spotted tail shark species (Carcharhinus sorrah) as many as 82 individuals (27.70%). The least caught shark species were the great hammerhead shark (Sphyrna mokkaran) with 1 individual (0.34%), tiger shark (Galeocerdo cuvier) with 1 individual (0.34%), and silvertip shark (Carcharhinus albimarginatus) with 1 individual (0.34%). The longline sharks based at Ujung Serangga Fish Landing Base have 9 fishing locations consisting of Ujung Batu Island, Gunung Sitoli Island, Asu Island, Siberut Island, Hinako Island, Bangkaru Island, Simuk Island, Pini Island and Pagai Island.
Growth patterns and condition factors of fish in the Celike River, leuser ecosystem area, East Aceh, Indonesia
Authors: Waliul Perdana Adli , Maghfiriadi Furqan , Maulizar Siti , Julismi Al , Dawami Muhammad , Nur Firman M.
Published: January 2025

Fish growth patterns are the process of increasing the size and weight of a fish's body that occurs during its lifetime. This growth pattern is influenced by genetic factors, the environment, food availability and the physiological condition of the fish. Research on Growth Patterns and Condition Factors of Fish in the Celike River in the Leuser Ecosystem Area of East Aceh aims to determine the size of fish and provide an overview of fish growth patterns by analyzing the relationship between length and weight and fish condition factors. The method used is a purposive sampling method, namely determining the location of research station based on consideration of habitat characteristics in locations that are thought to have a high presence of fish, are easy to reach and represent the Celike River area in the Leuser Ecosystem Area. This research was carried out in July 2024. The total number of fish obtained was 122 individuals from 10 species belonging to seven families, namely Cyprinidae, Sisoridae, Clariidae, Channidae, Cichlidae, Balitoridae, Aplocheilus. There are two dominant species caught at this location, namely Tor soro and Tor tambra. Tor tambra obtained during the study amounted to 40 individuals with a total length of 70.09 - 434.4 mm and a weight of 3.96 - 811.05 g. Tor soro) obtained during the study amounted to 34 individuals with a total length of 61.79 - 144.33 mm and a weight of 2.89 - 32.5 g. The growth pattern of fish in the Celike River with eight fish species is negative allometric, two fish species are isometric and positive allometric, with condition factor values ranging from 0.07 to 8.88.
Optimizing fishing time with Underwater Fish Lamp Plus (UFLPlus) technology: A strategy to enhance productivity and sustainability of boat lift net fisheries
Authors: Fajriah Fajriah , Togo Isamu Kobajashi , Nur Muhammad , Mustafa Ahmad
Published: January 2025

The UFLPlus technology is an innovative underwater fish lamp equipped with Closed Circut Television (CCTV). UFLPlus can enhance catch productivity by 41% and reduce fishing time, achieving an operational efficiency improvement of up to 33% in a single night. This innovation provides an effective and sustainable solution for lift net fisheries operating from boats. Boat lift net fishing methods often face challenges related to long fishing times, even when using submerged lamps as auxiliary tools. UFLPlus technology, with its optimal lighting system and integrated CCTV or image sensing. This study aims to evaluates the effectiveness of UFLPlus in improving the productivity of boat lift net fisheries by focusing on two key aspects: fishing time and productivity. It also compares UFLPlus with traditional underwater lamps without CCTV. Furthermore, it demonstrates that UFLPlus can significantly improve fishing time efficiency. The research was conducted in August 2024 in the boat lift net fishing grounds around Hari Island, South Konawe Regency, utilizing an experimental fishing method.
Constructing Figure-Eight Structures by Inner-Bond Cleavage
Authors: Fukui Norihito
Published: January 2025

Contemporary synthetic strategies in organic chemistry rely heavily on the stepwise formation of bonds between constituent fragments of the target compound, namely the bottom-up approach. However, this dependency poses significant challenges for the preparation of several classes of complex molecules, such as figure-eight molecules, despite their desirable functionality in advanced materials. Recently, we have developed an oxidative inner-bond-cleavage approach that enables a salable, catalytic, and enantioselective synthesis of figure-eight aromatic macrocycles. This Synpacts article summarizes the background, results, and outlook of our achievement. 1Introduction2Background3Our Contribution4Conclusion and Outlook
Osteosarcoma in Children Younger than 5 Years of Age: A Single-Center Case Series from India Depicting Their Clinical Features and Outcomes with Review of Literature
Authors: Parambil Badira Cheriyalinkal , Puri Ajay , Gulia Ashish , Prasad Maya , Gollamudi Venkata Rama Mohan , Ramadwar Mukta , Rekhi Bharat , Janu Amit , Purandare Nilendu , Chinnaswamy Girish
Published: January 2025

Background Osteosarcoma in children £5 years old is extremely rare. There is very limited information available on this subset, especially from India.

Methods We retrospectively analyzed the clinical presentation and outcomes in children £5 years old with osteosarcoma diagnosed between January 2013 and December 2022. Staging was performed by non-contrast computerized tomography of thorax and bone scans. Treatment included OGS-2012 chemotherapy protocol with local control by surgery at 12 weeks.

Results Eleven of 588 children were £5 years (1.9%). The majority had lower limb tumors (81.8%) with metastases in 45%. Nine patients (localized-6, metastatic-3) received treatment. Six patients with localized disease completed treatment with limb-salvage surgery, of whom two had a metastatic relapse and one died due to an unknown cause. Of three metastatic patients, two progressed and one died (due to dengue) while on neoadjuvant chemotherapy. Eight episodes of febrile neutropenia and five episodes of mucositis were documented in treated patients.

Conclusion Osteosarcoma in children £5 years of age is extremely rare with predominant lower limb tumors and relatively inferior outcomes in treated patients.
Is the Pressure from Blue Dye Cervical Injection Associated with Sentinel Lymph Node Detection in Laparoscopic Surgery for Endometrial Cancer?
Authors: Simonsen Marcelo , Amaral Marina Bandeira de Mello , Tayfour Najla Mohamed , Mayerhoff Eric Vieira Luna , Andrade Igor Marcondes de , Moreira Silva Lais , Antonini Marcelo , Teixeira Andressa Melina Severino
Published: January 2025

Introduction Sentinel lymph node biopsy (SLNB) has been proven to be a safe procedure in the treatment of endometrial cancer, and the instillment of a dye/marker in the cervix is the most used technique. Various studies have correlated the body mass index (BMI) impact as well as menopausal status and staging with the rate of lymph node detection, but few studies have evaluated if the high density of the cervix decreases detection.

Objective To quantify the injection pressure of the marker in the uterine cervix and to correlate it with the sentinel lymph node detection rate in endometrial neoplasia.

Materials and Methods Patients with endometrial cancer with programmed laparoscopic SLNB were selected to have the cervical injection pressure assessed. Immediately following the extraction of the uterus, saline solution was reapplied to measure injection pressure with a device attached to the syringe. We investigated the possible correlation of injection pressure with lymph node detection rate and the clinical data of the patients.

Results A total of 18 women participated in the study; a correlation between injection pressure and lymph node detection rate was not identified, neither was greater injection pressure detected in smaller uteruses or cervices. The pressure of the deep injection is greater than that of the superficial one, but the more medial application, or more lateral in relation to the midpoint, does not alter the injection pressure.

Conclusion The presence of greater resistance in the instillment of stain into the cervix was not associated with a lower lymph node detection rate.