bluuebunny/crossref_metadata_2025 huggingface dataset:
Corticotroph pituitary carcinoma with skeletal metastases masquerading as ectopic ACTH syndrome: a long and winding road to diagnosis
Authors: Van Mieghem Eugénie , Intan-Goey Valent , Buffet Wendi , Lammens Martin , Van Loo Pieter , Abrams Pascale
Published: March 2022

Pituitary carcinoma is a rare type of malignancy and only accounts for 0.1–0.2% of all pituitary tumours. Most pituitary carcinomas are hormonally active and they are mostly represented by corticotroph and lactotroph carcinomas. Corticotroph carcinoma can present as symptomatic Cushing’s disease or can evolve from silent corticotroph adenoma which is not associated with clinical or biochemical evidence of hypercortisolism. We hereby present a case of a bone-metastasized corticotroph pituitary carcinoma masquerading as an ectopic adrenocorticotropic hormone (ACTH) syndrome in a patient with a history of a non-functioning pituitary macro-adenoma. Our patient underwent two transsphenoidal resections of the primary pituitary tumour followed by external beam radiation therapy. Under hydrocortisone substitution therapy she developed ACTH-dependent hypercortisolism without arguments for recurrence on pituitary MRI and without central-to-peripheral ACTH-gradient on inferior petrosal sinus sampling, both suggesting ectopic production. Ultimately, she was diagnosed with an ACTH-secreting vertebral metastasis originating from the primary pituitary tumour. This case report demonstrates the complex pathophysiology of pituitary carcinoma and the long diagnostic work-up. Certain features in pituitary adenoma should raise the suspicion of malignancy.

Learning points

The diagnosis of pituitary carcinoma can only be made based on documented metastasis, therefore, due to the often long latency period between the detection of the primary tumour and the occurrence of metastasis, the diagnostic work-up most often spans over multiple years.

Pituitary carcinoma including corticotroph carcinoma is very rare in contrast to pituitary adenoma and only accounts for 0.1–0.2% of all pituitary tumours.

Histopathology in pituitary adenoma should certainly accomplish the following goals: accurate tumour subtyping and assessment of tumoural proliferative potential.

Repeated recurrence of pituitary adenoma after surgical resection, a discrepancy between biochemical and radiological findings, resistance to medical and radiation therapy, and silent tumours becoming functional are all hallmarks of pituitary carcinoma.

Silent corticotroph adenomas are non-functioning pituitary adenomas that arise from T-PIT lineage adenohypophyseal cells and that can express adrenocorticotropic hormone on immunohistochemistry, but are not associated with biochemical or clinical evidence of hypercortisolism. Silent corticotroph adenomas exhibit a more aggressive clinical behaviour than other non-functioning adenomas.

Treatment options for corticotroph carcinoma include primary tumour resection, radiation therapy, medical therapy, and chemotherapy. Sometimes bilateral adrenalectomy is necessary to achieve sufficient control of the cortisol excess.
Influence of dislocation structure on electrical and spectroscopic properties of MoOx/p-CdTe/MoOx heterostructures
Authors: Fodchuk I.M. , Kuzmin A.R. , Maslyanchuk O.L. , Hutsuliak I.I. , Solodkyi M.S. , Roman Yu.T. , Solovan M.M. , Gudymenko O.Yo.
Published: March 2022

The defective structure of p-CdTe:Cl single crystals and MoOx/p-CdTe/MoOx heterostructures were investigated by high-resolution X-wave diffractometry methods. Different models of dislocation systems were used and the dislocation densities were estimated from the Williamson-Hall plot. It is noted that significant deformations of the mismatch in the transition layer negatively affect the current–voltage characteristics of heterostructures.
Porous structure of carbon materials obtained from the shell of walnuts
Authors: Ivanichok N.Ya. , Ivanichok O.M. , Kolkovskyi P.I. , Rachiy B.I. , Sklepova S.-V.S. , Kulyk Yu.O. , Bachuk V.V.
Published: March 2022

Samples of porous carbon material (PCM) were obtained by carbonization of the feedstock (walnut shells). Small-angle X-ray scattering (SAXS) was used to study the porous structure of the obtained carbon materials. The fractal dimension of the surface increases and significant changes are observed in the distribution of the pore volume of the PCM samples with an increase in the carbonization temperature of the initial feedstock, which is especially pronounced for the sample obtained at 700 °C. It is shown that PCM obtained at 400-700 °С are macroporous materials, the maximum porous volume corresponds to pores with radius R ≈ 30 nm, and samples obtained at 700-1000 °C are mesoporous with R ≈ 5 nm.  The characteristics of the porous structure of the obtained materials were calculated on the basis of isotherms of low-temperature adsorption-desorption of nitrogen and it was shown that the carbonization temperature significantly affects the specific surface area and pore volume of PCM. It was determined that to obtain of PCM with an optimal ratio of micro- and mesopores, the temperature is 800 °C, at which the specific surface area of the carbon material is 238 m2/g with an average pore diameter of 2.2 nm.
Lesbianas y bisexuales en el sistema de salud ecuatoriano: garantía del derecho a salud sin violencia.
Authors: Garita Sánchez Ana Karen
Published: March 2022

Una de las principales problem?ticas que afecta a las mujeres lesbianas y bisexuales es la violencia, el rechazo familiar y social que conlleva en muchas ocasiones a recurrir a la invisibilidad o el ocultamiento de una parte del ser humano, como puede ser el caso de la orientación sexual. Dentro del ámbito de salud, dicho ocultamiento al momento de acudir a una atención médica también puede responder al factor de la discriminación, ya que los comportamientos y actitudes del personal de salud pueden llegar a casos extremos de violencia lesbofóbica, por ejemplo, a través del maltrato durante procedimientos gineco-obstétricos. Dicho lo anterior, mediante el uso de metodología cuantitativa y cualitativa se investiga sobre las percepciones que la población indicada tiene sobre el servicio de salud pública en una muestra de 75 mujeres; así como las impresiones de un grupo de 7 actores de salud que trabajan dentro del Sistema de Salud Pública en el centro “Las Casas” en Quito, que forma parte del programa piloto de centros incluyentes del Ministerio de Salud Pública. Los resultados más relevantes muestran que el 72% de las informantes tiene percepciones negativas sobre el Sistema de Salud, caracterizándolo principalmente con insuficiencia de información y un lugar en el que se sufren tratos discriminatorios. Además, se da cuenta de la importancia de mejorar las herramientas para el abordaje de información gineco-obstétrica para el caso de mujeres lesbianas y bisexuales, así como la importancia de la salud mental como un eje a considerar dentro de las prácticas del personal de salud que coadyuvan a la prevención y erradicación.
El transhumano: retos para la moral y la educación
Authors: Robles Loro Rafael
Published: March 2022

Mucho se está publicando acerca de la relación entre el transhumano y sus implicaciones educativas y, sobre todo, morales; el problema es que no se alcanza un acuerdo acerca de cómo serán dichas implicaciones entre las dos sensibilidades enfrentadas por este acontecimiento: transhumanistas y bioconservadores. En las siguientes páginas tratamos de hacer un retrato de la situación actual del debate y proponemos más preguntas abiertas desde nuestra postura más próxima al bioconservadurismo.
La mejora tecnológica del ser humano
Authors: Feito Lydia
Published: March 2022

Mejorar la condición humana puede ser un sueño o una pesadilla. Las técnicas actuales, especialmente las farmacológicas, que comienzan a estar disponibles, generan importantes problemas éticos. Muchas de sus promesas nos obligan a pensar si es deseable alcanzar el objetivo del posthumano, una suerte de humano mejorado cuyas características distan tanto del humano actual que es prácticamente inimaginable. Se trata de determinar si existe un modelo único de mejora, si buscamos alterar nuestras capacidades para alcanzar nuevos logros o si estamos aspirando a configurar un nuevo modo de ser, si con ello vamos a generar mayores desigualdades e injusticias. El análisis de los argumentos de este debate es el objeto de este texto cuya conclusión no puede ser otra que la llamada a la responsabilidad en las decisiones sobre nuestro futuro como seres humanos.
Rutile From the Zelenyi Yar Titanium-Zirconium Placer and Its Possible Primary Sources
Authors: PAVLIUK O.V. , PAVLIUK V.M.
Published: March 2022

Rutile of the Neogene-aged Zelenyi Yar titanium-zirconium placer was studied. The average size of the rutile grains is 0.25 mm that are elliptical, rounded, short-prismatic, isometric, and elongated-prismatic crystals in shape. On the surface of the crystals, elements of physical abrasion of varying degrees, as well as chemical dissolution, are observed. The color of the rutile crystals ranges from black to yellow with black and brown being the most common. A relationship between the concentration of various impurity elements and their variations with the color of the crystals is present. The highest average content of impurity elements is recorded in green rutiles and the lowest in light brown crystals. About 61% of the rutiles contain V2O5 (30% of all crystals; average content 1.28%), Nb2O5 (25%; 1.38%), FeO (24%; 1.10%), WO3 (9%; 0.91%), ZrO2 (9%; 0.85%), Al2O3 (2%; 0.70%), Cr2O3 (5%; 0.60%), SiO2 (7%; 0.57%). The temperature of primary rutile crystallization was calculated using Zr-in-rutile thermometry and corresponds to granulite and eclogite metamorphic conditions. Cluster analysis of 284 microprobe analyses of rutile allows at least five groups of crystals to be identified. According to the chemical composition of various rutiles, it can be concluded that they originated from metapelitic rocks, enderbites, and eclogite-like rocks located in the Dniester-Bug megablock of the Ukrainian Shield.
Zircon and Monazite as Geochronometers
Authors: STEPANYUK L.M.
Published: March 2022

The paper discusses the results of U-Pb isotope dating of monazites and zircons from granitoids formed under PT conditions of granulite and amphibolite facies and gneisses, and crystalline shales that are like xenoliths in these granitoids of the Ukrainian Shield. In some cases, such as the Berdychiv-type granitoids and in the Zhezhelivsky quarry, the age values of monazites and outer edges of zircons coincide well; in others, such as the granites of the Ivanivsky quarry, they differ by more than the error. In the Odessa quarry, even greater differences were found between the age of zircon (1.95-1.96 ± give errors Ga) from mafic granulite, and the age of zircon (1.99 Ga) and the age of monazite (1.89-1.83 ± Ga) of a crosscutting enderbite. The U-Pb isotope system of monazite from a vein of biotite granite common in this quarry does not meet the conditions of the Ahrens-Wetherill model. The 207Pb / 206Pb age of monazite ranges from 1909.5 to 1867.0 ± 5 Ma, i.e. by more than 40 Ma. For the Sabarivsky quarry, significant differences in the 207Pb / 206Pb age values (2015.8-1984.8 Ma), which significantly exceed the analytical error, do not allow the use of the concordia U-Pb diagram to interpret the analytical data obtained for zircons from the enderbite. It is concluded that monazite is the better mineral geochronometer, compared to zircon, to determine the age of palingenetic-anatectic granitoids. Unlike zircon, which usually inherits the relict nuclei of parent rocks, relict nuclei in monazites are an exception. However, monazite is not an ideal mineral geochronometer for determining the time of endogenous geological processes. Since the crystallization of monazite is depends on the activity of calcium in the environment, in the same rock association in rocks of different composition, monazite may crystallize at different times. The combination of radiometric studies of zircon and monazite, together with zoning of their crystals, provides ample opportunities to determine the time and duration of endogenous geological processes.
Renal Leiomyosarcoma, a Rare Presentation
Authors: Djiwa Toukilnan , Sabi Kossi Akomola , Simgban Panakinao , Bombonne Mayi , Sama Bagassam Mézéwè , Tchaou Mazamaesso , Darré Tchin
Published: March 2022

Renal sarcomas are very rare malignant tumours with a very poor prognosis. Renal leiomyosarcoma, a malignant tumour of smooth muscle origin, is the most common histological type. The article reports a case of leiomyosarcoma of renal location, with a review of the literature. A 38-year-old female patient, with no previous pathological history, consulted the nephrology department of the Teaching Hospital of Lomé for abdominal pain that had been present for 4 years. Histology showed a tumour proliferation of fasciculated architecture, made of spindle cells arranged in long bundles, with cytonuclear atypia and cytoarchitectural abnormalities. Immunohistochemical examination showed positive staining for smooth muscle actin, h-caldesmone, desmin and CD34 and negative for pancytokeratin (AE1/AE3), myogenin and PS100. Renal leiomyosarcoma is an exceptional malignancy. It remains the most common renal sarcoma, the differential diagnosis of which is based on immunohistochemical findings.
Facilitators and barriers to physical activity for people of Pacific heritage
Authors: Enoka Paige , Hale Leigh , Higgs Christopher
Published: March 2022

This research explored the facilitators and barriers to physical activity engagement for people of Pacific Island heritage. From an experiential constructionist position, we inductively applied thematic analysis to data collected via individual fully transcribed semi-interviews. Participants were five academics or tutors of Pacific Island descent interested in physical activity for Pacific peoples. The themes developed were: Centrality of community, Physical activity is something you do and It depends on the ‘environment’. Centrality of community was a prominent theme that spoke to the high value placed on collectivism and communitarianism by Pacific communities, which may limit individual choices of physical activity participation. Such collective principles may, however, facilitate physical activity through collective responsibility for all to engage in health endeavours. Optimal facilitators of physical activity may be (i) mobilising a community response to participation in physical activity by motivating through improved understanding of the health benefits of physical activity for the community as a whole, (ii) a response role-modelled and championed by community leaders (such as church leaders) and (iii) choosing activity programmes that are group- and community-based, fun and social occasions. Approaches that target the individual, both in health benefits and individually based activities, may be less successful.
RESEARCH ON ANTIBACTERIAL FINISHING PROCESS OF CHROMOLAENA ODORATA EXTRACT ON COTTON FABRIC FOR ULCER PREVENTION PURPOSE
Authors: Hung Phan Ngoc , Huong Bui Mai
Published: March 2022

Global healthcare is facing various topical challenges related to skin diseases due to aging populations and the dreadful aftermath of previous wars. In developing countries, the vast majority of people with special needs have been taken care of at charity shelters with limited caring conditions and thus faced various significant skin problems and ulcers. Therefore, there is a high demand for not only effective medical textiles but also accessible technology for wide applications. By taking advantage of Vietnamese local herb and available textile finishing technology, this study indicated an environment-friendly finishing process for cotton fabrics by developing the antibacterial function of Chromolaena odorata extract. It was effective in preventing ulcers for people who suffer from skin problems and ulcers. Substances from C. odorata leaves were extracted and applied to fabrics by utilizing exhaustion method. We investigated parameters related to extraction and finishing processes, including solvent concentration, solid/liquid ratio, drying temperature, washing durability, FT-IR analysis, and pH value. The investigation results showed that the finished fabrics reached a high antibacterial rate (approximately 88.24 % for S. aureus and 95.59 % for E. coli), and had a compatible pH value (5.2) with human skin. To sum up, the study was efficient and environmentally benign, making it a handy way to help the inadequate healthcare system at charity shelters and nursing homes.
BEHAVIOUR OF PASSIVE FILMS ON STAINLESS STEEL EXPOSED IN VARIOUS CORROSIVE CONDITIONS
Authors: Le Do Nhu Tuong , Tran Mai Han , Bui Thi Thao Nguyen , Nguyen Ba Tai , Nguyen My Anh , Nguyen Nhi Tru
Published: March 2022

Corrosion behavior of different steel grades such as 304 and 445NF types with passive films formed under various corrosive environments was examined according to ASTM G61-86 (2014). The distinctive susceptibility of the steel grades to local corrosion in chloride solutions was also discussed. A distinction in corrosion of these steel grades was defined by different austenitic and ferritic natures as well as their elemental compositions. Besides, a corrosion survey of these materials was also conducted for constructions exposed in various atmospheric natural areas ranging from benign rural to aggressive marine conditions. Damages were detected at surfaces of popularly used constructions made of Type 304 stainless steel, where more severe deterioration was observed in the area with higher airborne salinity; examination on Type 445 stainless steel in the same environmental conditions gave results of less severe deterioration and milder damages on surfaces in comparison to Type 304. Different states of passive films also affect the result of the experiments. Corrosion appearance and corrosion products examined by visual inspection and EPMA techniques for steel surfaces showed the influence of airborne salinity on the degree of damage. Corrosion of the steel surfaces was attributed to the combined effect of atmospheric airborne salinity and high time-of-wetness (TOW).
Yeast goes viral: probing SARS-CoV-2 biology using S. cerevisiae
Authors: Ho Brandon , Loll-Krippleber Raphael , Brown Grant W.
Published: March 2022

The budding yeast Saccharomyces cerevisiae has long been an outstanding platform for understanding the biology of eukaryotic cells. Robust genetics, cell biology, molecular biology, and biochemistry complement deep and detailed genome annotation, a multitude of genome-scale strain collections for functional genomics, and substantial gene conservation with Metazoa to comprise a powerful model for modern biological research. Recently, the yeast model has demonstrated its utility in a perhaps unexpected area, that of eukaryotic virology. Here we discuss three innovative applications of the yeast model system to reveal functions and investigate variants of proteins encoded by the SARS-CoV-2 virus.
BOXING SPEED AND MUSCLE SCIENTIFIC TRAINING
Authors: Wu Qingsong
Published: March 2022

ABSTRACT Introduction: Boxing is a sport that requires a lot of explosive power, that is, it demands from its practitioners not only to use their strength, but to do so very rapidly. Objective: To analyze the influence of muscle training on the explosive power of boxers, providing a theoretical reference for the training of their core strength. Methods: This article makes a statistical analysis of boxing explosive power and analyzes the factors relevant to punch speed. Results: The key factors that affect the maximum speed of the straight punch in boxing are the maximum elbow joint flexion and extension, angular velocity, and the maximum trunk angular velocity. Conclusion: In daily training, attention should be paid to upper limb strength and core strength training, which is the only way for boxers to have a correct body posture and ensure a reliable center of gravity when punching. Level of evidence II; Therapeutic studies - investigation of treatment results.
THE SCIENTIFIC SYSTEM OF HUMAN CORE BALANCE IN SPORTS
Authors: Dong Huan , Kong Kai , Ma Qianli
Published: March 2022

ABSTRACT Introduction: The human brain controls the body's balance, actinh on the muscle tissues of the body and thus controlling the balance of its center of gravity. Objective: To analyze 6 indicators that affect the brain's ability to control the body's balance and to verify the important muscle areas of the human body and prove that strength training can help improve the body's balance ability. Methods: This article selected young university students with the same physical fitness as sample and analyzed the factors that affect the body's strength and balance using statistical models. Results: Strength training can effectively improve the body›s balance when standing. Conclusion: Training the brain to control the body is mainly to exercise strength, stability, balance, and other abilities of human muscle tissue. Using this kind of exercise method can effectively improve the stability of the human body. Targeted training can also enhance the brain's ability to control the balance of the body. Level of evidence II; Therapeutic studies - investigation of treatment results.
RELATIONSHIP BETWEEN UNBALANCED CORE STRENGTHENING AND INJURIES IN DANCESPORT ATHLETES
Authors: Huang Huali
Published: March 2022

ABSTRACT Introduction: The set of muscles in the lumbo-pelvic-hip complex is called the core. The core is located in the body's center of gravity. Dancesport require aligned trunk movements and permanent stabilization between the spine and pelvis. Despite few studies, the relationship between unbalanced core strengthening and injuries in dancesport is investigated. Objective: Study the relationship between unbalanced core strengthening and muscle strength in dancesport athletes. Methods: An experiment was conducted with 60 students from dance schools. They were randomly divided between an experimental group and a control group, with 30 people each. Each group included 15 males and 15 females. The experimental group used unilateral core stability training. The control group used traditional core stability training. Results: The results showed that the quality of action improved significantly after core strength training (P <0.05), but there was no significant difference between the two groups. Conclusions: Core strengthening can improve balance ability in athletes. There was no statistical difference between the training, with similar positive balance ability and explosion strength effects in the athletes. Level of evidence II; Therapeutic studies - investigation of treatment results.
CALISTHENICS EXERCISES TO INTERVENE IN OBESITY AND DIABETES IN MIDDLE-AGED PEOPLE
Authors: Kong Ningning , Yang Guantong , Wang Lixia , Li Yang
Published: March 2022

ABSTRACT Introduction: There is an annual increase in type 2 diabetes (T2DM) incidence in middle-aged people. Aerobic exercise is known to influence glucose metabolic pathways positively. Few studies concerning calisthenic aerobic exercise and its influence on elderly patients with T2DM. Objective: To measure the therapeutic effect of calisthenic exercise in obese Middle-aged people with T2DM. Methods: A total of 86 patients with T2DM were selected from the physical examination of employees of the same unit. They were randomly divided into the exercise group and the control group. The exercise intervention lasted for 16 weeks, with sessions held 3-5 times per week, varying from 60 to 90 minutes per session. The markers evaluated were defined according to the literature and statistically verified. Results: After 16 weeks of calisthenic exercise intervention, compared to the control group or before the experiment, we observed significant reductions in variables VFA (visceral fat area), FPG (fasting glucose), Fins (fasting insulin), HOMA-IR (homeostasis model evaluation of insulin resistance), 2hPBG (postprandial two hours glucose) and HbAlc (hemoglobin Alc) of the exercise group were significantly reduced (P<0.01). Conclusion: Calisthenic exercise intervention can reduce the levels of VFA, FPG. FIns, HOMA-HR, 2hPBG and HbAlc in patients with T2DM. It was also found to reduce the visceral fat content of obese elderly patients with T2DM, reducing obesity risks. Level of evidence II; Therapeutic studies - investigation of treatment results.
VALUE OF ECHOCARDIOGRAPHIC DIASTOLIC FUNCTION REACTIVITY UNDER EXERCISE LOAD
Authors: Dai Yuanliang
Published: March 2022

ABSTRACT Introduction: Left ventricular diastolic dysfunction is one of the important long-term survival and prognosis factors in patients with coronary heart disease. Objective: To evaluate the diastolic function of the left ventricle in patients with coronary heart disease (CHD) using 3D speckle tracking echocardiography (3D-STE). Methods: Full volume images of four apical cavities were collected, and 4D Auto LVQ software was used for offline analysis to obtain longitudinal strain (GLS), circumferential strain (GCS), area strain (GAS) and radial strain (GRS) of the left ventricle as a whole (four three-dimensional strain indicators). Results: The receiver operating characteristic (ROC) curve analysis showed that the sensitivity and specificity of GLS in predicting left ventricular diastolic dysfunction were both 68% at −15.5%. The sensitivity and specificity of GCS for predicting left ventricular diastolic dysfunction at −17.5% were 76% and 81%, and those of GAS at −29.5% were 84% and 68%, respectively. Conclusions: The strain parameters of 3D-STE can be used to predict LVEDP in patients with coronary heart disease with normal left ventricular ejection fraction, and can be used as a new ultrasonic diagnostic index to evaluate left ventricular diastolic function in patients. Level of evidence II; Therapeutic studies - investigation of treatment results.
PHYSICAL CHANGES IN TAEKWONDO ATHLETES CAUSED BY STRENGTHENING THE CORE
Authors: Liu Tao , Yan Feng
Published: March 2022

ABSTRACT Introduction: Taekwondo is a complete sport with combative nature among related sports. Their athletes need a higher strike force in the legs and a body with relatively high sensitivity and stability. The center of force production, from which all movements originate, is called the core. Objective: The purpose of this study is to analyze possible physical changes in Taekwondo athletes caused by strengthening the core. Methods: Baseline data from core training was recorded using various scientific analysis methods. Rigorous methods of comparison were also employed. The six indices of athletic ability were tested in experimental and control groups in Taekwondo athletes. Results: The data in the athletes’ strength and exercise styles before and after core strengthening showed significant differences. Conclusion: Strengthening the core of athletes can rapidly improve the development of physical strength. Core strengthening is an effective procedure for improving strength training in Taekwondo athletes. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
Immunosuppressant Medication Use in Patients with Kidney Allograft Failure: A Prospective Multicenter Canadian Cohort Study
Authors: Knoll Greg , Campbell Patricia , Chassé Michaël , Fergusson Dean , Ramsay Tim , Karnabi Priscilla , Perl Jeffrey , House Andrew A. , Kim Joseph , Johnston Olwyn , Mainra Rahul , Houde Isabelle , Baran Dana , Treleaven Darin J. , Senecal Lynne , Tibbles Lee Anne , Hébert Marie-Josée , White Christine , Karpinski Martin , Gill John S.
Published: March 2022

Significance Statement

Current recommendations suggest discontinuation of immunosuppressants 1 year after kidney transplant failure. In this first prospective multicenter study of 269 patients with kidney transplant failure in 16 Canadian centers, most patients were prescribed immunosuppressants for longer than 2 years. Continued use of immunosuppressants was not associated with an increased risk of death or hospitalized infection. However, the continued use of immunosuppressants did not prevent rejection of the failed allograft or an increase in anti-HLA antibodies, possibly due to inadequate drug exposure. The findings challenge current recommendations and highlight the need for a controlled trial of immunosuppressant use in patients with transplant failure.

Background

Patients with kidney transplant failure have a high risk of hospitalization and death due to infection. The optimal use of immunosuppressants after transplant failure remains uncertain and clinical practice varies widely.

Methods

This prospective cohort study enrolled patients within 21 days of starting dialysis after transplant failure in 16 Canadian centers. Immunosuppressant medication use, death, hospitalized infection, rejection of the failed allograft, and anti-HLA panel reactive antibodies were determined at 1, 3, 6, and 12 months and and then twice yearly until death, repeat transplantation, or loss to follow-up.

Results

The 269 study patients were followed for a median of 558 days. There were 33 deaths, 143 patients hospitalized for infection, and 21 rejections. Most patients (65%) continued immunosuppressants, 20% continued prednisone only, and 15% discontinued all immunosuppressants. In multivariable models, patients who continued immunosuppressants had a lower risk of death (hazard ratio [HR], 0.40; 95% confidence interval [CI], 0.17 to 0.93) and were not at increased risk of hospitalized infection (HR, 1.81; 95% CI, 0.82 to 4.0) compared with patients who discontinued all immunosuppressants or continued prednisone only. The mean class I and class II panel reactive antibodies increased from 11% to 27% and from 25% to 47%, respectively, but did not differ by immunosuppressant use. Continuation of immunosuppressants was not protective of rejection of the failed allograft (HR, 0.81; 95% CI, 0.22 to 2.94).

Conclusions

Prolonged use of immunosuppressants >1 year after transplant failure was not associated with a higher risk of death or hospitalized infection but was insufficient to prevent higher anti-HLA antibodies or rejection of the failed allograft.
Disability and Exclusion: Social, Education and Employment Perspectives
Authors: Sarkar Ratan , Parween S.
Published: March 2022

When the whole world is striving towards the inclusion of persons with disabilities (PwDs) in all walks of life, they are still among the vulnerable group who are at risk of social exclusion. The meaningful participation in societal activities is hindered by marginalisation at an individual level leading to unemployment and thus poverty. Disability, social exclusion and poverty are inextricably associated that despite poverty alleviation programmes, disability reforms, advocacy and disability acts, these marginalised group of disabled individuals still remain as victims. The dynamic relationship between these three is studied in this article to to examine some of the issues of the human rights approach towards disability rehabilitation. Due to the systemic, structural and attitudinal barriers, developing countries like India are still struggling to create an inclusive society. This article suggests measures to overcome the challenges faced by persons with disabilities so as to initiate steps towards successful inclusion.
Biomonitoring of Health of Chubachu Stream Using Macroinvertebrate Diversity
Authors: Dorji Tandin , Tshering Sonam , Wangchuk Norbu , Acharja Indra P.
Published: March 2022

Biomonitoring, to assess the water quality of the Chubachu stream was conducted using macroinvertebrate diversity as an indicator to determine the level of pollution and the impact of wastewater discharge from settlements along the stream. The study site was divided into two zones based on the density of settlements as dense or sparse, with 3 sampling points in each zone. The assessment was performed using the Biological Monitoring Working Party (BMWP) score system. A total of 693 specimens were collected belonging to 19 families. The study found that the level of water pollution is directly correlated to settlement density. The water flowing through the sparse settlements is

substantially lesser polluted compared to a densely populated area. The study found 4.5 – 61500 CFU/100mL of thermotolerant coliform in the area, significantly higher than the permissible limit for drinking water as per Bhutan Drinking Water Quality Standard (BDWQS) & World Health Organization (WHO); which is 0 CFU/100mL. The study also found that the discharge of untreated sewage and dumping waste directly into the stream is the primary source of pollution. Realigning sewage discharge into municipality sewage network, treatment of wastewater, and proper management of waste by residents living along the stream can help reduce pollution and improve the water quality
Lise Öğrencilerinin Akran Zorbalığına Maruz Kalma Düzeylerini Yordayan Değişkenlerin İncelenmesi
Authors: SÜZÜK Erol , AKINCİ Tuncay
Published: March 2022

Zorbalık dünya çapında yaygın bir sorundur ve büyük ölçekli araştırmalar çocukların yaklaşık %25'inin okulda zorbalığa uğradığını bildirmektedir. Zorbalık davranışı ülke çapında eğitimciler için önemli bir sosyal ve sağlık sorunu olmaya devam etmektedir. Okul zorbalığı ile ilgili çok fazla söylem olmasına rağmen, önceki çalışmalar birey, ebeveyn ve öğretmen değişkenleri gibi faktörlerin yordayıcı etkisini açıklamada sınırlıdır. Okul sisteminin paydaşları olan aile, öğretmen ve öğrencilerle ilgili faktörlerin akran zorbalığı ile ilişkisinin anlaşılması bu konuda alınması gereken önlemlere ışık tutması açısından önemlidir. Bu araştırmanın amacı lise öğrencilerinde aile (sosyoekonomik statü ve sosyal destek), öğretmen (sınıf içi disiplin, öğretmen desteği, öğretmen dönütü ve öğretmen ilgisi) ve öğrenci (dayanıklılık, hedef yönelimi ve rekabetçilik) faktörlerinin akran zorbalığı ile ilişkilerini incelemek ve bu faktörlerin akran zorbalığına maruz kalma düzeylerini ne kadar yordadığını ortaya koymaktır. İlişkisel tarama modelinin kullanıldığı bu çalışmanın verileri PISA uygulamasından alınmıştır. Hiyerarşik regresyon analizinin kullanıldığı çalışmaya 6368 lise öğrencinin verileri dâhil edilmiştir. Araştırma bulgularına göre, ailenin sosyal desteği zorbalığa maruz kalmanın en önemli yordayıcısıdır. Sosyoekonomik statü ile zorbalığa maruz kalma arasında anlamlı bir ilişki bulunmamaktadır. Sınıf içi disiplini iyi sağlayan, öğrencilerine destek veren ve öğrencisiyle ilgilenen öğretmenlerin sınıflarında daha az zorbalık davranışı görülmektedir. Dayanıklılık düzeyi yüksek öğrenciler zorbalığa daha az maruz kalmaktadır.
Mülteci Öğrencilerin Fen Bilimleri Dersine Yönelik Tutumlarının Okula Yabancılaşma Üzerindeki Etkisinde Derste Yapılan Etkinliklerin Aracılık Rolü
Authors: ÖRÜCÜ Edip , KURT Pınar , HASIRCI Itır
Published: March 2022

: Bu araştırmanın amacı, Suriyeli mülteci öğrencilerin fen bilimleri dersine yönelik tutumlarının okula yabancılaşma üzerindeki etkisinde fen bilimleri dersinde yapılan etkinliklere yönelik tutumların aracılık etkisini tespit etmektir. Araştırmanın evrenini Ankara’da bulunan 7 farklı okulda öğrenim gören 1370 Suriyeli mülteci öğrenci oluşturmaktadır. Araştırmanın örneklemini ise bu okullarda öğrenim gören 347 Suriyeli mülteci ortaöğretim öğrencisi oluşturmaktadır. Veriler anket uygulaması aracılığı ile elde edilmiştir. Anketten elde edilen verilere frekans analizi, güvenilirlik analizi, normallik testi, çoklu korelasyon analizi ve aracı değişkenle hiyerarşik regresyon analizi uygulanmıştır. Yapılan analizler sonucunda öğrencilerin fen bilimleri dersine yönelik tutumlarının, okula yabancılaşma üzerindeki etkisinde, fen bilimleri dersinde yapılan etkinliklere yönelik tutumlarının kısmi aracılık etkisinin olduğu tespit edilmiştir. Araştırma konusu ile ilgili daha önce herhangi bir çalışmaya rastlanılmadığından yapılan bu araştırmanın literatüre ve diğer uygulayıcılara önemli katkılar sağlayacağı umulmaktadır.
İlköğretim Matematik Öğretmen Adaylarının Diskalkuliye İlişkin Görüşleri
Authors: BALDEMİR Bilal , İÇ Ünal , TUTAK Tayfun
Published: March 2022

Bu çalışma ilköğretim matematik öğretmen adaylarının öğrenme güçlüğü türlerinden biri olan diskalkuliye, diğer bir ifadeyle matematik öğrenme güçlüğüne ilişkin farkındalıklarını ve görüşlerini incelemek amacıyla yapılmıştır. Bu amaç doğrultusunda ilk olarak diskalkuli nedir sorusu için derinlemesine cevaplar aranmış, diskalkulik öğrencilerin karekteristik özellikleri, diskalkulinin tanı ve tedavisi betimlenmiştir. Ayrıca ilköğretim matematik öğretmen adaylarının diskalkuli hakkındaki farkındalıkları ve görüşleri detaylı olarak incelenmiştir. Araştırma nitel desenli bir yöntemle gerçekleşmiştir. Çalışma örneklemi olarak bir devlet üniversitesi ilköğretim matematik öğretmenliği bölümünde okuyan 36 öğretmen adayı belirlenmiştir. Araştırmada diskalkuliye ilişkin 5 açık uçlu soru içeren yarı yapılandırılmış görüşme formu kullanılmış ve elde edilen verilerin analizinde betimsel analiz tekniği kullanılmıştır. Çalışma sonucunda ilköğretim matematik öğretmen adaylarının diskalkuliye ait terimleri doğru tanımlayamadığı ve hangi süreçlerin nasıl ve ne şekilde uygulanması gerektiği fikrine sahip olmadıkları belirlenmiştir. Bu kapsamda elde edilen sonuçlardan yola çıkarak ilköğretim matematik öğretmenliği lisans programı içerisine “çeşitli öğrenme güçlükleri ve giderme yöntemleri” biçiminde spesifik bir dersin yerleştirilmesi, öğretmen adaylarının konu hakkında uzmanlar tarafından bilgilendirilmesi ve duyarlılıklarının artırılmasına yönelik projelerin yürütülmesi gerektiği önerilmiştir.
Values of Mathematics Education In Turkish High School Mathematics Textbooks
Authors: BAKIRCI Damla , BİBER Abdullah
Published: March 2022

The purpose of this study is to examine how mathematics education values are included in Turkish high school mathematics textbooks. Mathematics education values describe the learning and teaching processes of mathematics. Mathematics education values are considered as five complementary pairs: formalistic view-activist view, operational understanding-relational understanding, relevance-theoretical knowledge, accessibility-special, and evaluating-reasoning. Document analysis method was used in the research. The sample of the study was determined examples in the mathematics textbooks used in high schools in the 2019-2020 academic year. A total of 2175 questions were examined within the scope of the research. Content analysis was used in the analysis of qualitative data, and the obtained data were classified as mathematical value pairs. Accordingly, it was found that values of formalistic view, theoretical knowledge, operational understanding, evaluating, and accessibility were emphasized more than complementary values in the studied books. Accordingly, considering the importance of mathematics education values for mathematics textbooks, it may be advisable to pay attention to the balanced distribution of these complementary value pairs in textbooks.
Working memory based early intervention program for gifted preschoolers: an effectiveness study
Authors: KARADAĞ Filiz , YILDIZ DEMİRTAŞ Vesile
Published: March 2022

In the literature, it has been shown that working memory, which plays an important role in cognitive development of preschool children and is a concept intertwined with cognitive activities, can be improved. The purpose of this study is to examine the effect of early intervention programs for improving working memory on the working memory performance of gifted children in the pre-school period. In the study, pre-test post-test experimental design of unequal groups of quasi-experimental designs was used. While an early intervention program to improve working memory was applied to the experimental group, the control group did not benefit from this training. The study group of the research consisted of a total of 67 children. The data collection tools used in the study consisted of three groups: scales for identifying and typical development, the scale for determining effectiveness of the early intervention program, and scales to determine the social validity of the study. The quantitative findings showed that the early intervention program developed improved the working memory performance of both gifted and typically developing children. In addition, the students who participated in the study and their parents and teachers found the early intervention program useful. It was observed that the study provided social validity.
[RETRACTED] Super Slim Gummies Reviews - *Shocking Ingredients* Trusted Formula For Weight Loss To Use? v1
Authors: not provided robermowray
Published: March 2022

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DNA metabarcoding protocol for siphonophore gut contents v2
Authors: Damian Serrano Alejandro
Published: March 2022

Protocol for the SiphWeb DNA metabarcoding of siphonophore gut content. Starting with DNA extractions from pooled frozen gastrozooids, this protocol takes the user through the steps of PCR amplification, PCR cleanup and pooling of amplicons from six complementary 18S barcodes that can be submitted into an Illumina MiSeq Lane.
[RETRACTED] Aktiv Formulations Keto BHB - Why Diet The Most Important Factor? Try Aktiv Keto BHB Pills! v1
Authors: Keto BHB Aktiv
Published: March 2022

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[RETRACTED] Aktiv Keto BHB - Fast Working Pills | Fasting with Easy & Tasty Pills (2022 Updated) v1
Authors: Keto BHB Aktiv
Published: March 2022

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Automated DNA template preparation and quantitation methods v1
Authors: Romantseva Jane , Ross David , Alperovich Nina , Strychalski Elizabeth
Published: March 2022

Concentrated, intact, and biologically-active DNA templates are essential for protein production using cell-free expression. We present automated methods for DNA template preparation and quantitation towards improving reproducibility in cell-free expression.
[RETRACTED] FunDrops CBD Gummies Shark tank - Where To Buy It 2022? v1
Authors: not provided fundropsgummiesshark
Published: March 2022

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Increasing Efficiency of the Oil Production Using Hydraulic Screw Pumps at Iraq's Judaida Oilfield
Authors:   Siberian Federal University, Almohammad Alnayef M.
Published: March 2022

The article describes in detail the operation principle of the screw pump and gives recommendations on the use of screw-type hydraulic machines to reduce the cost of oil production on the example of a field in Iraq
Adaptive Regulation of the Spectral Component of the Radiation Power of a Multiwave Laser System
Authors:   Joint-Stock Company «Concert «Sozvezdie», Koziratsky Anton A.
Published: March 2022

This article presents a method for increasing the energy efficiency of systems using laser radiation for information transmission by automatically selecting a rational radiation power. A model of the process of adaptive adjustment of the spectral component of the radiation power of a multiwave laser system has been developed based on the analysis of the magnitude of the optical signal reflected from the retroreflector in order to ensure the required level of laser radiation power for reliable information transmission by each separate channel. In the software environment MATLAB Simulink, on the basis of the mathematical apparatus of the theory of automatic control, an imitation of the process under study was made and the adequacy of the proposed model was confirmed. The model implies the possibility of its correction by changing the amplifying and inertial properties of the circuit elements to describe particular cases of the functioning of a multiwave laser system
Evaluation of the Effectiveness of Group Actions of airfighters, with Joint Guidance of Attacking Fighters and Cover Airfighters
Authors:   Military Academy of Aero-Space Defence named after the Marshal of Soviet Union G. K. Zhukov, Bogdanov Alexander V.
Published: March 2022

This article defines and justifies the efficiency indicator of group actions of airfighters in the form of the average number of saved airfighters in the process of group air confrontation. Based on the model of the dynamics of averages, the dependence of this tactical indicator of the effectiveness of group actions on the technical indicator of the effectiveness of the on-board radar system in the conditions of unintended interference in the form of the implemented suppression coefficient of the on-board radar system and the approach based on the distribution of private tactical tasks between the fighters of the group is established. Calculations and simulations have been carried out, indicating an increase in the effectiveness of group actions of fighters in the distribution of tasks of an attacking fighter and a fighter as part of a group and taking into account these tasks in the guidance process
Design of Vortex Jet Gripping Devices for Automatic Loading of Process Equipment
Authors:   Siberian Federal University, Konischeva Olga V.
Published: March 2022

The questions of use of vortex and jet effects for automation of loading of processing equipment are taken up. The designs of gripping devices capable to hold the objects having a flat surface are considered. Deduction happens due to creation of a vacuum in the field of the capture adjoining to the object plane. The structural elements are proposed that allow increasing the area and size of negative pressure, which increases the lifting force. Vortex jet gripping devices are a perspective load facility of the technological equipment owing to profitability, simplicity and other advantages. In this paper, we consider possible design schemes of vortex jet grippers and their effect on the device load capacity and also depending on the design features of the captured objects
On the Choice of Some Modifiers when Creating Composite Nickel-phosphorus Coatings
Authors:   Don State Technical University, Shcherbakov Igor N.
Published: March 2022

The article considers the issues of choosing some modifiers of composite nickel-phosphorus coatings (CNiPC) using the method of crystal-chemical design in order to create high reliability and durability in the friction units of machines and mechanisms of tribological systems (TS). The paper shows the possibility of improving the tribological and anti-corrosion properties of NiP coatings without modifiers by introducing modifying additives into the coatings – ultradisperse powders of simple and complex metal oxides, oxides with corundum and rutile structures, simple substances with magnesium and tungsten structures, and polytetrafluoroethylene