bluuebunny/crossref_metadata_2025 huggingface dataset:
Protective Immune Response against Bacillus anthracis Induced by Intranasal Introduction of a Recombinant Adenovirus Expressing the Protective Antigen Fused to the Fc-fragment of IgG2a
Authors: Shcherbinin D. N. , Esmagambetov I. B. , Noskov A. N. , Selyaninov Yu. O. , Tutykhina I. L. , Shmarov M. M. , Logunov D. Yu. , Naroditskiy B. S. , Gintsburg A. L.
Published: March 2020

Anthrax is a particularly dangerous infectious disease that affects humans and livestock. It is characterized by intoxication, serosanguineous skin lesions, development of lymph nodes and internal organs, and may manifest itsself in either a cutaneous or septic form. The pathogenic agent is Bacillus anthracis, a grampositive, endospore-forming, rod-shaped aerobic bacterium. Efficacious vaccines that can rapidly induce a long-term immune response are required to prevent anthrax infection in humans. In this study, we designed three recombinant human adenovirus serotype-5-based vectors containing various modifications of the fourth domain of the B. anthracis protective antigen (PA). Three PA modifications were constructed: a secretable form (Ad-sPA), a non-secretable form (Ad-cPA), and a form with the protective antigen fused to the Fc fragment of immunoglobulin G2a (Ad-PA-Fc). All these forms exhibited protective properties against Bacillus anthracis. The highest level of protection was induced by the Ad-PA-Fc recombinant adenovirus. Our findings indicate that the introduction of the Fc antibody fragment into the protective antigen significantly improves the protective properties of the Ad-PA-Fc adenovirus against B. anthracis.
Internalization and Recycling of the HER2 Receptor on Human Breast Adenocarcinoma Cells Treated with Targeted Phototoxic Protein DARPinminiSOG
Authors: Shilova O. N. , Proshkina G. M. , Lebedenko E. N. , Deyev S. M.
Published: March 2020

Design and evaluation of new high-affinity protein compounds that can selectively and efficiently destroy human cancer cells are a priority research area in biomedicine. In this study we report on the ability of the recombinant phototoxic protein DARPin-miniSOG to interact with breast adenacarcinoma human cells overexpressing the extracellular domain of human epidermal growth factor receptor 2 (HER2). It was found that the targeted phototoxin DARPin-miniSOG specifically binds to the HER2 with following internalization and slow recycling back to the cell membrane. An insight into the role of DARPin-miniSOG in HER2 internalization could contribute to the treatment of HER2-positive cancer using this phototoxic protein.
Cytomegalovirus in Plasma of Acute Coronary Syndrome Patients
Authors: Nikitskaya E. A. , Grivel J. C. , Maryukhnich E. V. , Lebedeva A. M. , Ivanova O. I. , Savvinova P. P. , Shpektor A. V. , Margolis L. B. , Vasilieva E. Yu.
Published: March 2020

The relationship between acute coronary syndrome (ACS) and local and systemic inflammation, including accumulation of macrophages in atherosclerotic plaques and upregulation of blood cytokines (e.g., C-reactive protein (CRP)), has been known for more than 100 years. The atherosclerosis-associated inflammatory response has been traditionally considered as an immune system reaction to low-density lipoproteins. At the same time, some data have indicated a potential involvement of cytomegalovirus (CMV) in the activation and progression of atherosclerosis-associated inflammation, leading to ACS. However, these data have been tangential and mainly concerned the relationship between a coronary artery disease (CAD) prognosis and the anti-CMV antibody titer. We assumed that ACS might be associated with CMV reactivation and virus release into the bloodstream. The studys aim was to test this assumption through a comparison of the plasma CMV DNA level in patients with various CAD forms and in healthy subjects. To our knowledge, no similar research has been undertaken yet. A total of 150 subjects (97 CAD patients and 53 healthy subjects) were examined. Real-time polymerase chain reaction (RT-PCR) was used to determine the number of plasma CMV DNA copies. We demonstrated that the number of plasma CMV genome copies in ACS patients was significantly higher than that in healthy subjects (p = 0.01). The CMV genome copy number was correlated with the plasma CRP level (p = 0.002). These findings indicate a potential relationship between CMV activation and atherosclerosis exacerbation that, in turn, leads to the development of unstable angina and acute myocardial infarction. Monitoring of the CMV plasma level in CAD patients may be helpful in the development of new therapeutic approaches to coronary atherosclerosis treatment.
Dipole Modifiers Regulate Lipid Lateral Heterogeneity in Model Membranes
Authors: Efimova S. S. , Ostroumova O. S.
Published: March 2020

In this study we report on experimental observations of giant unilamellar liposomes composed of ternary mixtures of cholesterol (Chol), phospholipids with relatively low Tmelt (DOPC, POPC, or DPoPC) and high Tmelt (sphingomyelin (SM), or tetramyristoyl cardiolipin (TMCL)) and their phase behaviors in the presence and absence of dipole modifiers. It was shown that the ratios of liposomes exhibiting noticeable phase separation decrease in the series POPC, DOPC, DPoPC regardless of any high-Tmelt lipid. Substitution of SM for TMCL led to increased lipid phase segregation. Taking into account the fact that the first and second cases corresponded to a reduction in the thickness of the lipid domains enriched in low- and high-Tmelt lipids, respectively, our findings indicate that the phase behavior depends on thickness mismatch between the ordered and disordered domains. The dipole modifiers, flavonoids and styrylpyridinium dyes, reduced the phase segregation of membranes composed of SM, Chol, and POPC (or DOPC). The other ternary lipid mixtures tested were not affected by the addition of dipole modifiers. It is suggested that dipole modifiers address the hydrophobic mismatch through fluidization of the ordered and disordered domains. The ability of a modifier to partition into the membrane and fluidize the domains was dictated by the hydrophobicity of modifier molecules, their geometric shape, and the packing density of domain-forming lipids. Phloretin, RH 421, and RH 237 proved the most potent among all the modifiers examined.
YABBY3-Orthologous Genes in Wild Tomato Species: Structure, Variability, and Expression
Authors: Filyushin M. A. , Slugina M. A. , Shchennikova A. V. , Kochieva E. Z.
Published: March 2020

Evolution of the genes encoding YABBY transcription factors is believed to be one of the key reasons for flat leaf emergence from the radially symmetrical stem and gynoecium diversity. YABBY genes determine the identity of the abaxial surface of all aboveground lateral organs in seed plants. In the present study, complete sequences of YABBY3-orthologous genes were identified and characterized in 13 accessions of cultivated and wild tomato species with diverse morphophysiology of leaves, flowers, and fruits. The obtained gene sequences showed high homology (95-99%) and an identical exon-intron structure with the known S. lycopersicum YABBY3 gene, and they contained sequences that encode the conserved HMG-like YABBY and Cys2Cys2-zinc-finger domains. In total, in the analyzed YABBY3 genes, 317 variable sites were found, wherein 8 of 24 exon-specific SNPs were nonsynonymous. In the vegetative and reproductive organs of red-fruited and green-fruited tomato species, YABBY3 gene expression was similar to that in S. pimpinellifolium described earlier, but it demonstrated interspecies differences at the leaf-, bud- and flower-specific expression levels.
Gamma-Carbolines Derivatives As Promising Agents for the Development of Pathogenic Therapy for Proteinopathy
Authors: Skvortsova V. I. , Bachurin S. O. , Ustyugov A. A. , Kukharsky M. S. , Deikin A. V. , Buchman V. L. , Ninkina N. N.
Published: March 2020

Uncontrolled protein aggregation, accompanied by the formation of specific inclusions, is a major component of the pathogenesis of many common neurodegenerative diseases known as proteinopathies. The intermediate products of this aggregation are toxic to neurons and may be lethal. The development strategy of pathogenic therapy for proteinopathy is based on the design of drugs capable of both inhibiting proteinopathy progression and increasing the survival of affected neurons. The results of a decade-long research effort at leading Russian and international laboratories have demonstrated that Dimebon (Latrepirdine), as well as a number of its derivatives from a gamma-carboline group, show a strong neuroprotective effect and can modulate the course of a neurodegenerative process in both in vitro and in vivo model systems. The accumulated data indicate that gamma-carbolines are promising compounds for the development of pathogenic therapy for proteinopathies.
Construction of a Full-Atomic Mechanistic Model of Human Apurinic/Apyrimidinic Endonuclease APE1 for Virtual Screening of Novel Inhibitors
Authors: Khaliullin I. G. , Nilov D. K. , Shapovalova I. V. , Švedas V. K.
Published: March 2020

A full-atomic molecular model of human apurinic/apyrimidinic endonuclease APE1, an important enzyme in the DNA repair system, has been constructed. The research consisted of hybrid quantum mechanics/ molecular mechanics modeling of the enzyme-substrate interactions, as well as calculations of the ionization states of the amino acid residues of the active site of the enzyme. The choice of the APE1 mechanism with an Asp210 residue as a proton acceptor was validated by means of a generalization of modeling and experimental data. Interactions were revealed in the active site that are of greatest significance for binding the substrate and potential APE1 inhibitors (potential co-drugs of interest in the chemo- and radiotherapy of oncological diseases).
Development of Chlamydial Type III Secretion System Inhibitors for Suppression of Acute and Chronic Forms of Chlamydial Infection
Authors: Zigangirova N. A. , Zayakin E. S. , Kapotina L. N. , Kost E. A. , Didenko L. V. , Davydova D. Yu. , Rumyanceva J. P. , Gintsburg A. L.
Published: March 2020

The Type III secretion system (T3SS) is currently considered to be one of the main pathogenicity factors in Gram-negative bacteria, which exhibit different types of parasitizing activity. The presence of this structure is essential for the development of an acute infection; the chronicity of the infection is fundamentally dependent upon its functioning. In this regard, T3TS is one of the most promising targets for the development of broad-spectrum antimicrobial drugs that do not develop resistance and are efficacious for the acute and chronic forms of infection. The mechanism of action in drug development is based on the specific inhibition of T3SS, which should interrupt the infectious process, thereby enabling the immune system to eliminate the pathogen. As a result of pilot screening using specific cellular and bacterial tests, followed by chemical optimization and detailed characterization of the biological activity, a new class of chlamydial T3SS inhibitors was obtained. The selected compounds have obvious advantages over the currently available inhibitors of T3SS pathogens thanks to the high inhibitory activity of these compounds with minimal damaging effects on eukaryotic cells. Preclinical trials of the selected inhibitors are currently under way.
PERBANDINGAN PEMBIAYAAN BERMASALAH ANTARA BANK SYARIAH DENGAN BANK KONVENSIONAL
Authors: Indriastuti Maya , Pratiwi RIrih Dian
Published: March 2020

ABSTRACT The financing growth of sharia bank for five years is very strategic because it has become themain source of income for sharia bank. However, this growth was not followed by the position of nonperformingfinancingratiowhichisinthesecondquarterof2015reacheduntil4.6%.Thisfigureisfairabovethe conventional bank's non-performing loans (NPLs) at 2.46% in the same period. Thisstudy analyzed and empirically tested the difference between sharia bank NPF and conventional bankNPL. The population in this study are all active and registered banks in Bank Indonesia from 20122016.Sampling method based on purposive sampling, with samples used are banks engaged inconventional and sharia in one institution as many as 10 Banks. The test results indicate that thereare differences in non-performing financing between sharia banks and conventional banks. Averagenon-performing financing at sharia banks amounted to 2.64% while the average non-performingloans at conventional banks was 1.29%. This indicates that the non-performing financing of shariabanks is worse compared to the non-performing loans in conventional banks. Therefore, sharia banksare more cautious in the distribution of working capital financing.  Keywords: sharia banking; conventional banking; non performing financing (NPF); non performingloans (NPL)  ABSTRAK Pertumbuhan pembiayaan bank syariah selama lima tahun ini sangat strategis karena telahmenjadi sumber pendapatan yang utama bagi bank syariah. Namun, pertumbuhan ini tidak diikutioleh posisi rasio pembiayaan bermasalah yang pada kuartal II tahun 2015 mencapai 4,6%. Angkatersebut jauh di atas kredit bermasalah (NPL) bank konvensional di level 2,46% pada periode yangsama. Penelitian ini menganalisis dan menguji secara empiris perbedaan NPF bank syariah denganNPL bank konvensional. Populasi di penelitian ini adalah seluruh bank yang aktif dan terdaftar diBank Indonesia dari tahun 2012-2016. Metode pengambilan sampel berdasarkan purposive sampling,dengan sampel yang digunakan adalah bank yang bergerak di konvensional maupun syariah dalamsatu institusi sebanyak 10 Bank. Hasil pengujian menunjukkan bahwa terdapat perbedaanpembiayaan bermasalah antara bank syariah dengan bank konvensional. Rata-rata pembiayaanbermasalah pada bank syariah sebesar 2,64% sedangkan rata-rata pembiayaan bermasalah padabank konvensional sebesar 1,29%. Hal ini mengindikasikan bahwa pembiayaan bermasalah padabank syariah lebih buruk dibandingkan dengan pembiayaan bermasalah pada bank konvensional.Oleh karena itu, bank syariah lebih berhati-hati dalam penyaluran pembiayaan modal kerja  Kata Kunci: perbankan syariah; perbankan konvensional; non performing financing (NPF); nonperforming loan (NPL)
PENILAIAN KINERJA KEUANGAN PERUSAHAAN DENGAN ANALISIS DU PONT SYSTEM STUDI KASUS PADA EMPAT PERUSAHAAN TELEKOMUNIKASI YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE TAHUN 2014 - 2018
Authors: Hidayat Yuliatma , Aminah Indianik , Novitasari Novitasari
Published: March 2020

PENILAIAN KINERJA KEUANGAN PERUSAHAAN DENGAN ANALISIS DU PONT SYSTEM STUDI KASUS PADA EMPAT PERUSAHAAN TELEKOMUNIKASI YANG TERDAFTAR DI BURSAEFEK INDONESIA PERIODE TAHUN 2014 - 2018  A.Yuliatma Hidayat ayuliatmahidayat@gmail.com Indianik Aminahindianikmashuri@gmail.comNovitasarinovitasari26@gmail.comProgram Studi Akuntansi Keuangan Terapan Politeknik Negeri Jakarta   ABSTRACT The purpose of this research is to find out how the financial performance of PTTelekomunikasi Indonesia Tbk, PT XL Axiata Tbk, PT Indosat Tbk and PT Smartfren Telecom Tbk byusing the Du Pont System Method. Data analysis method used in this research is Du Pont SystemMethod. The variables used in this study are Total Asset Turnover (TATO), Net Profit Margin (NPM),and Return On Investment (ROI). The data used are secondary data in the form of company financialstatements. The results showed that PT Telekomunikasi Indonesia Tbk has a very good financialperformance where all variables are above the industry average. PT XL Axiata Tbk has a fairly goodfinancial performance because only the Net Profit Margin variable is above the industry average. PTIndosat has a relatively good financial performance where only the Total Asset Turnover variable isabove the industry average. PT Smartfren Telecom Tbk has poor financial performance because allvariables are below the industry average.  Keywords: Du Pont System, Return On Investment, Net Profit Margin, Total Asset Turnover ABSTRAKTujuan Penelitian ini adalah untuk mengetahui bagaimana kinerja keuangan perusahaan PTTelekomunikasi Indonesia Tbk, PT XL Axiata Tbk, PT Indosat Tbk dan PT Smartfren Telecom Tbkdengan menggunakan Metode Du Pont System. Metode analisis data yang digunakan dalampenelitian ini adalah Metode Du Pont System. Variabel yang digunakan dalam penelitian ini adalahTotal Asset Turnover (TATO), Net Profit Margin (NPM), dan Return On Investment (ROI). Data yangdigunakan merupakan data sekunder berupa laporan keuangan perusahaan. Hasil penelitianmenunjukkan bahwa PT Telekomunikasi Indonesia Tbk memiliki kinerja keuangan yang sangat baikdimana semua variabel berada diatas rata-rata industri. PT XL Axiata Tbk memiliki kinerja keuanganyang cukup baik karena hanya variabel Net Profit Margin yang berada diatas rata-rata industri. PTIndosat tbk memiliki kinerja keuangan yang cukup baik dimana hanya variabel Total Asset Turnoveryang berada diatas rata-rata industri. PT Smartfren Telecom Tbk memiliki kinerja keuangan yangtidak baik karena semua variabel berada dibawah rata-rata industri.  Kata kunci: Du Pont System, Return On Investment, Net Profit Margin, Total Asset Turnover.
Analisis Kebutuhan Kompetensi Pekerja Industri Kulit/Alas Kaki Menyongsong Era Industri 4.0
Authors: Broto Taukhid W , Pujiyanto Risang
Published: March 2020

Industry 4.0 competency model has three areas of competence as salience, there is Information Systems, Computer Science, and Engineering. It hence requires adaptability to SKKNI Golongan Pokok Industri Kulit, Barang dari Kulit and Alas Kaki to accommodate these three areas as part of the competence that must be owned by industrial workers. The analysis of competency needs of leather industry and footwear industry aims to produce SKKNI accordance recommendation to the concept of industry standard 4.0. The method used is point-to-point correlation between predictors and criteria initiated by (Bartram, 2005) and further developed by (Prifti, Knigge, Kienegger, & Krcmar, 2017). In the end SKKNI which is embraced through the application of this recommendation will be use as reference for the formal and non-formal curriculum education improvement to prepare industry workforce towards industry 4.0 era.
Persepsi Dosen Terhadap Penggunaan ICT Dalam Pembelajaran Bahasa Inggris
Authors: Dewi Sari Puspita , Abdillah Abdul Azis , Sofa Nidia
Published: March 2020

Studi ini dilaksanakan untuk mengetahui bagaimana persepsi dosen terhadap penggunaan teknologi digital, yang biasa disebut information & communication technology (ICT), pada pembelajaran bahasa Inggris yang digunakan oleh dosen kepada mahasiswa. Metode penelitian yang digunakan adalah metode kualitatif dengan data kuantitatif. Dalam proses pengumpulan data, penulis menggunakan dua perangkat penelitian berupa kuesioner, dan wawancara terhadap dosen bahasa Inggris di PNJ. Pengkajian ini dilakukan dengan mengumpulkan informasi terkait persepsi dosen terhadap penggunaan ICT, dan juga mengidentifikasi kendala dalam penggunaan ICT pada pembelajaran bahasa Inggris. Hasil penelitian menunjukkan 100% responden setuju bahwa pengajaran bahasa Inggris sangat cocok dipadukan dengan ICT, juga setuju bahwa penggunaan ICT juga dapat membuat pembelajaran menjadi sangat menyenangkan. Sedangkan, terkait kegunaan ICT bagi Mahasiswa, 18% responden tidak setuju dengan manfaat pengajaran ICT yang akan mempermudah mahasiswa dalam mendapatkan pekerjaan (yang layak) dimasa yang akan datang. Selain itu juga, 15 hingga 25% responden juga tidak setuju bahwa pembelajaran menggunakan ICT dapat membantu mahasiswa memahami materi secara mendalam, kemudian meningkatkan nilai bahasa Inggris, dan membantu mahasiswa dalam berkomunikasi. Namun, terdapat beberapa kendala ditemukan secara intrinsik dan ekstrinsik. Kendala yang dialami dosen paling besar merupakan kompetensi dosen dalam menggunakan ICT sekaligus juga pengalaman-pengalaman buruk yang pernah dialami dosen dalam penggunaan ICT dalam kelas. Pada kendala ekstrinsik, masalah yang dihadapi dosen adalah kurangnya pelatihan ICT dan masalah koneksi internet. Kendala-kendala ini membuat para dosen menjadi berpikir dua kali dalam mengoptimalkan penggunaan ICT dalam kelas. Hasil penelitian ini dapat menjadi bahan evaluasi bagi dosen bahasa Inggris selaku pelaksana di lapangan dan bagi institusi sebagai pembuat kebijakan.
Kesadaran Bela Negara Pada Mahasiswa
Authors: Rahayu Minto , Farida Rita , Apriana Asep
Published: March 2020

Kesadaran bela negara itu hakikatnya ialah kesediaan berbakti pada negara dan kesediaan berkorban membela negara. Tercakup di dalamnya adalah bersikap dan berbuat yang terbaik bagi bangsa dan negara. Wujud bela negara ialah cinta tanah air, kesadaran berbangsa dan bernegara, yakin akan kesaktian Pancasila, rela berkorban untuk bangsa dan negara, serta mempunyai kemampuan awal bela negara. Metode penelitian yang digunakan ialah angket dengan analisis kuantitatif pada nilai mean. Kesadaran bela negara pada mahasiswa diimplemtasikan pada membuang sampah pada tempat yang disediakan, perlindungan dan keamanan bagi masyarakat sudah baik, taat beragama dengan sudah melaksanakan dan menjalankan ibadah dan menjaga kerukunan hidup di antara sesama umat beragama dan kepercayaan terhadap Tuhan yang Maha Esa, sadar telah membina diri saya sendiri agar dapat mandiri kelak, dan bangga kepada perjuangan para pahlawan. Namun ada kesadaran bela negara pada mahasiswa masih kurang yaitu turut menjaga keamanan lingkungan kampus, tidak cukup mewakili kampus dalam kegiatan olah raga dan seni, masih mengedepankan kepentingan pribadi dibadingkan kepentingan bangsa dan negara, cenderung memilih tidak memilih (golput) pada pemilu mendatang, dan kurang berminat menjadi anggota menwa atau tentara.
Analisis Permasalahan Pelaksanaan Praktik Kerja Lapangan Mahasiswa Program Studi D-3 Administrasi Bisnis Jurusan Administrasi Niaga Politeknik Negeri Jakarta
Authors: Sugianingsih Ni Made Widhi , Syarweni Narulita , Utomo Wahyudi
Published: March 2020

Praktek Kerja Lapangan (PKL) merupakan salah satu bentuk implementasi secara sistematis dari program pendidikan yang ada di program Studi Administrasi Bisnis. Mahasiswa dapat mengaplikasikan dan mempraktekkan secara langsung teori dan praktik yang sudah diperoleh di perkuliahan, dengan kegiatan kerja secara langsung di dunia kerja, baik itu di perusahaan swasta, perusahaan BUMN, ataupun di Instansi Pemerintah. Evaluasi terhadap pelaksanaan program praktik kerja lapangan ini perlu terus dilakukan dalam upaya mengatasi permasalahan yang dihadapi dan upaya perbaikan serta penyempurnaan. Penelitian ini bertujuan untuk memperoleh gambaran yang lengkap dan mengevaluasi mengenai permasalahan yang dialami mahasiswa dalam melaksanakan praktik kerja lapangan, sehingga nantinya dapat dilakukan perbaikan dan penyempurnaan. Di samping itu pula mengevaluasi buku pedoman praktik kerja lapangan dan penulisan laporan tugas akhir agar dapat direvisi. Analisis data dilakukan dengan pendekatan kualitatif deskriptif, yaitu dengan mengeksplorasi program kegiatan praktik kerja lapangan dengan tujuan memperoleh deskripsi tentang permasalahan, penggalian informasi yang beragam melalui kuesioner, wawancara dengan mahasiswa, dosen pembimbing, serta struktural jurusan, sehingga diperoleh upaya untuk mengatasi permasalahan yang ada. Sebagai responden dalam penelitian ini adalah seluruh mahasiswa dan mahasiswi semester 6 yang sudah melaksanakan praktik kerja lapangan pada tahun akademik 2017/2018. Adapun hasil dari penelitian ini adalah memang ditemukan permasalahan yang dialami oleh mahasiswa, seperti pada saat pengajuan PKL terkait dengan penentuan tempat PKL, bidang peminatan, dan kendala administrasi. Pada saat pelaksanaan PKL terkait dengan jangka waktu PKL, kesesuaian bidang pekerjaan dan penilaian. Setelah pelaksanaan PKL selesai, terkait dengan kendala komunikasi dan kurangnya pemahaman pada penggunaan buku pedoman PKL dan penulisan laporan tugas akhir.
Using Antconc Software As English Learning Media: The Students’ Perception
Authors: Khairas Eri Ester
Published: March 2020

The use of techonology for a method in learning is rapidly developed and effect the students’ learning process. This research is aimed to find out about the perception of college students about a learning method of English by using a software named AntConc. The data were collected through questionnaires divided into pre-questionnaire and post-questionnaire. Pre questionnaire was about students’ perception towards AntConc software itself and the post questionnaire was about students’ perception using the software. The respondents were 51 students of Engineering Department, Politeknik Negeri Jakarta.. This research shows that Antconc software can be an alternative method to enhance students learning of English by using some tools on its software.
Pengaruh Kualitas Pelayanan terhadap Loyalitas Pelanggan Mujigae Resto Depok
Authors: Wijiyanti Menik , Mariam Iis , Dewi Yusthika Prasetya Probo
Published: March 2020

This research is conducted to analyze the influence of service quality toward costumer loyalty Mujigae Resto Depok. This is quantitative research with descriptive analysis. The sample of this research are people who ever come to Mujigae Resto Depok minimum two times in last six months. This research using validation test, reliability test, normality test, linearity test, and hypothesis test consisting of simple linear reggresion analysis, determination coefficient analysis (R2), partial statistic analysis (t test), and simple linear reggresion analysis. Based on the result of determination coefficient analysis (R2), amount 34,9% of costumer loyalty Mujigae Resto Depok is influenced by service quality. It can be concluded that service quality has a significant influence toward costumer loyalty Mujigae Resto Depok.
Pengaruh Citra Merek Dan Harga Terhadap Keputusan Pembelian Maskara Maybelline (Studi Kasus Pada Mahasiswi Administrasi Niaga Politeknik Negeri Jakarta)
Authors: Fahira Sarah , Hartati Tuti , Amir Hafniza
Published: March 2020

Respondents in this study amounted to 80 people who were students of the Department of Commercial Administration of the Jakarta State Polytechnic who had bought Maybelline mascara. The results showed that brand image factors and prices influence the purchasing decisions of Maybelline mascara. This is evidenced by the regression coefficient of 0.503. Brand image has a positive and significant influence on purchasing decisions of Maybelline mascara with a value of 0,017 <0,10. This is because the brand image is the initial foundation of consumers to be able to choose what products to use. Prices have a positive and significant influence on consumer purchasing decisions with a value of 0.005 <0.10. This is because each consumer has a perception of a price, if the price offered is suitable then the consumer can choose the product or want to use. Brand image and price together influence the purchasing decision of Maybelline mascara with a significance value of 0,000 <0.10.
PENGEMBANGAN PERANGKAT PEMBELAJARAN BERBASIS COURSELAB PADA PRINSIP KERJA ENGINE BIDANG KEAHLIAN KENDARAAN RINGAN
Authors: Wahyudi Imam , Wijayanti Fitri
Published: March 2020

Development research focused on developing Courselab-based learning aids on the principle of Light Vehicle Engine Expertise which includes Student Books, Student Activity Sheets and Lesson Plans for grade XI SMK students. The model of development used in this research refers to the model of learning aids development of Dick & Carey which consists of three phases, namely (1) identification phase; at this stage the writing of goals and analysis of instructional learning is conducted, identifying initial behaviors and characteristics of the students, (2) development phase; at this stage the Courselab-based learning tools is developed by formulating the goals and the standard reference tests, as well as developing the strategies and the learning aids, (3) testing and evaluation phase. The developed Courselab-based learning aids has been validated by two experts with revision to obtain a result which is fit to use. The tests carried out in three stages, namely one-on-one testing, small group testing conducted at SMK Nasional Makassar to evaluate the practicality of the learning aids and limited testing conducted at SMK Darussalam Makassar to evaluate the practicality and the effectiveness of the learning aids. The research results show that the developed learning aids, after the validation, was declared valid. The learning aids is attributed practical as the students responded positively to the learning aids they used. The learning aids is considered effective as the students responded positively to the learning aids used. It has met the criteria of effectiveness, with the results: (1) student activities have met the predetermined tolerance limits, (2) the teacher activities have fulfilled the observed aspects, and (3) the student learning outcomes on the working engine principle materials have achieved completeness.
La telenovela histórica mexicana: un modo de memoria, dos modelos narrativos
Authors: Charlois Allende Adrien José
Published: March 2020

Este artículo propone la revisión de la evolución de la telenovela histórica mexicana, pensada como un modo de memoria cultural, a través de la descripción del género melodramático como matriz narrativa. Esta descripción lleva a pensar en la constitución de un modo de recuerdo que se ha articulado en dos modelos básicos y que remedia hechos y personajes de la historiografía nacionalista, lo que lo convirtió en un apoyo cultural al discurso oficial sobre el pasado nacional.
Leadership Practice for Building Trust of Followers: Decisive Factors of Organizational Performance
Authors: Le Ba Phong , Tran Quang Thang
Published: March 2020

Purpose - Leadership plays a decisive role in key organizational outcomes. To investigate the effects of leadership and its mechanism on organizational performance, this paper examined how transformational leadership impacts followers’ trust for improving operational and financial performance in the case of Vietnamese firms.
Design/Methodology - This study used the Structural Equation Modeling to assess the correlation among the constructs based on using survey data of 285 employees at 60 manufacturing and service companies.
Findings - The findings revealed that employees' trust in leadership acts as a mediating mechanism in the relationship between transformational leadership and organizational performance. The transformational leadership style of leaders has greater effects on financial performance, while employee’s trust has larger effects on operational performance. This study calls attention to the importance of raising employee trust to link transformational leadership and organizational performance.
Practical and theoretical implications - From a practical point of view, the paper brings more knowledge and insights for CEO/managers on the right pathway to enhance organizational performance. The paper also provides theoretical initiatives on the leadership theory and the new pathway to promote operational and financial performance.
MOTÉIS DE PEQUENO PORTE: NOVAS PERSPECTIVAS DE MERCADO
Authors: Serrão Victor Antunes de Souza , Araújo Jucymara Soares , Justi Jadson , Justi Jamson , Justi Edrilene Barbosa Lima
Published: March 2020

O objetivo deste estudo é descrever as novas perspectivas da gestão de serviços para o setor moteleiro de pequeno porte. Tal pesquisa se respalda na possibilidade de se propor uma adequação de segmento de mercado para a prestação de serviços em motéis de pequeno porte, uma vez que esses empreendimentos podem estar sofrendo dificuldades de crescimento dentro do segmento dado ao atual perfil do setor. Metodologicamente é engendrado como descritivo com abordagem qualitativa, embasando-se em um estudo de caso em um motel de pequeno porte de Parintins, Amazonas, Brasil. Os resultados indicam pouca motivação e expectativa por parte da proprietária do motel lócus deste estudo em relação ao seu próprio negócio. Em épocas sazonais, há um grande prejuízo financeiro e incapacidade de gestão da empresa em oferecer estratégias de inovação para alavancar o negócio. Conclui-se a necessidade de atualização do regimento que regulamenta os meios de hospedagem oficial no Brasil. A legislação vigente pode ser um dos fatores-chave que levam os motéis de pequeno porte à falência, pois os estabelecimentos moteleiros possuem pouca ou nenhuma abertura de crédito aos bancos e, por isso, mudam de segmento de mercado. Tem-se como reflexão de que não há necessidade de mudança de segmento de mercado e sim uma adaptação própria para o avanço na condução evolutiva do setor moteleiro.Palavras-Chave: Motéis. Administração de serviços. Novas perspectivas de mercado. MOTELS: NEW MARKET PERSPECTIVESAbstract: The objective of this research is to describe the new perspectives of service management for the small motel sector. It is proposed to adapt the market segment to the provision of services in motels, since these enterprises may be experiencing growth difficulties within the segment in the current profile of the sector. This study is characterized as descriptive with a qualitative approach, based on a case study in a small motel in Parintins, Amazonas, Brazil. The results indicate little motivation and expectation on the part of the owner of the motel in relation to her own business. In seasonal times, there is a great financial loss and inability to manage the company in offering innovation strategies to develop the business. It is concluded that there is a need to update the regiment that regulates the means of official hosting in Brazil. Current legislation may be one of the key factors driving small motels into bankruptcy, since the establishments in question have little or no credit opening by financial institutions, and therefore change market segments. One has to reflect that there is no need to change market segment, but rather an adaptation to the evolutionary advance of the motel sector.Keywords: Motels. Administration of services. New market prospects.
PERBEDAAN HASIL BELAJAR SISWA DALAM PEMBELAJARAN BIOLOGI DENGAN MENGGUNAKAN MEDIA YOUTUBE DI MA ANNAJAH PONPES AL HALIMY SESELA
Authors: Fatmawati Any , Nofisulastri Nofisulastri , Adawiyah Siti Rabiatul , Devi Novia Sarita
Published: March 2020

This study aims to determine differences in student learning outcomes in biology learning by using youtube media at MA Annajah Ponpes Al Halimy Sesela. This study involved 53 students of class IX MA, with 27 students for the experimental class and 26 students for the control class. This type of research is a quasi-experimental with post-test only control group design and the determination of samples using purposive sampling. The data collected is the data of student learning outcomes and student responses after participating in biology learning using youtube media. Learning outcome data were analyzed using an independent test sample T-Test in significance 5% with SPSS 16.00 for windows. The results of the analysis of learning outcomes data show that p = 0.008, so that H0 is rejected and Ha is accepted, that is there is no difference between the average learning outcomes of group A who follow the learning with youtube media and group B with learning not to use youtube media. The conclusion from this study is that there are differences in learning outcomes between students who take learning using Youtube media and students who take conventional learning (without Youtube) at MA Annajah Ponpes Al Halimy Sesela.
ANALISIS KANDUNGAN ANTISEPTIK GETAH TUMBUHAN PATIKAN KEBO (Euphorbia hirta) SEBAGAI DASAR PEMBUATAN BROSUR PENANGANAN LUKA RINGAN PADA MASYARAKAT
Authors: Widiarto Mahendra , Janiarta Muhammad Abdurrahman , Intan Putri Komala , Hajiriah Titi Laily
Published: March 2020

Patikan Kebo (Euphorbia hirta) leaves are often used as traditional medicine and have been proven to be natural antiseptics. We use this society as a basis for analyzing its antiseptic content clinically through laboratory testing. The test results will then be presented in the form of a brochure. The brochure that will be distributed before going through the 4D model development stage. The method used in this study is the maceration method to proceed to the phytochemical test. The results of this study found the presence of iodine in the sap and alkaloid content and tanin through phytochemical tests through screening tests. The results of this study are then presented in the form of a brochure with a validation test from 2 experts obtaining an average score of 3.2 in the good category. Based on the results of the analysis it can be concluded that it is true that Patikan Kebo (Euphorbia hirta) contains antiseptic compounds that can heal wounds so that it can be informed to the public through a well-validated health brochure for distribution to the public.
IMPLEMENTASI WORKSHEET BERORIENTASI PEMBELAJARAN INKUIRI UNTUK MENGAJARKAN KETERAMPILAN PROSES SAINS MAHASISWA
Authors: Mursali Saidil , Hajiriah Titi Laily
Published: March 2020

Learning science including biology is strived to lead to the formation of skills not only relies on conceptual mastery. So it is necessary to instill skills in students through teaching and learning activities, one of them is science process skills. FPMIPA IKIP Mataram students are currently future candidates for natural science educators who have the responsibility to train their students to achieve the expected learning outcomes. Science process skills are one of the life skills that a person must possess in facing competition in the 21st century. These skills can be trained through inquiry learning. This study aims to describe the students' science process skills after being taught using an inquiry-oriented worksheet. This type of research is a pre-experimental design with one shoot case study. Data collection techniques are observation and quantitative descriptive analysis. The results of this study indicate the science process skills of students who use an inkuri-based worksheet of 75.73 with good categories. Based on the results above, the conclusion of this research is the science process skills of students after the implementation of the inquiry-oriented worksheet on average reaches a good category.
KEANEKARAGAMAN HAYATI AIR TERJUN TIBU BUNTER – SESAOT SEBAGAI POTENSI EKOWISATA
Authors: Zulhariadi Muhammad , Kuswara R. Didi , Munzir Mohammad
Published: March 2020

Lombok is one of the main islands in Indonesia that has a variety of ecosystem types that have the potential to be developed into ecotourism. The purpose of this study is to identify the biodiversity composing the ecosystem of Tibu Bunter Waterfall as one of the potentials of ecotourism. Explorative descriptive research type. The research location is located in Tibu Bunter Waterfall, Pesantek Hamlet in Pakuan Village, Narmada District - West Lombok. The results showed that there were 14 animal species and 21 plant species found around the Tibu Bunter Waterfall. Of the several animal species found, there is one unique species in the Least Concern category based on IUCN RED LIST (2011), namely needle dragonflies with a Calopterygidae pregnancy. In the plant species found there are several types of canopy plants, bamboo species, nail plants, bush plants, herbaceous plants, to mosses. It was concluded that the ecosystem of the Tibu Bunter Waterfall has high biodiversity potential and developed into an ecotourism area.
IDENTIFIKASI JENIS ANNELIDA PADA HABITAT SUNGAI JANGKOK KOTA MATARAM
Authors: Azhari Nizar , Nofisulastri Nofisulastri
Published: March 2020

Jangkok River is one of the lotic ecosystems in the city of Mataram. Based on previous studies it was concluded that this river has various types of biodiversity in it. The purpose of this study was to identify the types of Annelida found in the Jangkok River in Mataram City. This type of research is descriptive exploratory research with quantitative and qualitative approaches. This research was conducted on March 14, 2018. The research samples were river water taken at 3 stations namely upstream, middle and downstream using purposive sampling technique. Based on its existence, the Annelida type was found in downstream stations as many as 46 individuals, and 5 at the middle station, whereas it was not found at the upstream station. The type of Annelida found is the Olygochaeta class with Lumbricus terestis species and Tubifex sp. and the Hirudinae class with Hirudo medicinalis species.
PENGEMBANGAN LKS BERBASIS KEARIFAN LOKAL UNTUK PENINGKATAN KETERAMPILAN PENYELESAIAN MASALAH SISWA
Authors: Khatimah Husnul , Utami Septiana Dwi , Mursali Saidil
Published: March 2020

LKS has been implemented in schools in general and has not presented problems related to local wisdom in learning so that students do not develop their skills. The research objective is to develop LKS based on local wisdom and improve problem-solving skills. The type of research Research and Development that uses a 4D model includes defining, designing, developing, and disseminating. The instruments in the study were validation sheets, learning implementation observation sheets (RPP), observation sheets for problem-solving skills, and student response questionnaires. Data collection techniques used is validation, observation, questionnaire, documentation. The results showed that the development of local wisdom-based LKS was feasible with a validity level of 3.59 (valid / non-revised categories). The implementation of RPP learning with an average value of 88.4% (very good category), problem-solving skills of students with an average value of 75 (good category), with quality improvement reaching at 0.42 (medium category), average value the student response questionnaire is 3.70 (very good category). Based on the above results it can be concluded that the LKS based on local wisdom that has been developed is declared valid/not revised and is feasible to use and can improve students' problem-solving skills.
PENGEMBANGAN LKS BERBASIS PERMAINAN KARTU DOMINO UNTUK PENINGKATAN HASIL BELAJAR KOGNITIF SISWA
Authors: Widiarto Mahendra , Hajiriah Titi Laily , Armiani Sucika
Published: March 2020

Based on the results of preliminary observations at SMP Negeri 10 Mataram shows that students are less involved in the learning process, students tend to be passive and their interest in learning is not optimal due to the lack of variation in the use of instructional media by teachers and have never used the media of domino cards. Therefore, through the development of a domino card based worksheet it is hoped that it can improve student cognitive learning outcomes. This research is a research development with the aim to determine the shape and feasibility of student worksheets (LKS) based on domino cards. Student worksheets (LKS) based on domino cards are student worksheets with the substance of natural science material that are more interesting and enjoyable to learn than other media because this domino card game fosters excessive curiosity and is challenged to seek statements with right answers. The development model in this study is the 4-D model of Thiagarajan, Semmel and Semmel (1974) which consists of 4 stages, namely: 1) Define; 2) Design; 3) Develop; and 4) Disseminate. In this study only three stages were carried out, namely the define, design and develop stages. The role of the validator will be requested after the develop stage is completed. The results of this study obtained an average score of expert validation results of 78.33%. The results of the analysis of the implementation of this device obtained a presentation by students at 94% with a very practical category and from the analysis of the teacher in terms of practicality of the device by 70% with a practical category while the cognitive learning outcomes of students with classical completeness were 80%. Based on the results of the study it can be concluded that the development of a domino card-based worksheet can improve student cognitive learning outcomes.
IDENTIFIKASI SERTA HUBUNGAN KONSTRUKSI SUMUR GALI TERHADAP KANDUNGAN COLIFORM PADA AIR SUMUR GALI DI DUSUN JIKEN KABUPATEN LOMBOK TIMUR
Authors: Yuliansari Dini
Published: March 2020

The well is one of the source water used for bathing, washing, and drinking by the citizens in Jiken Hamlet, Rarang Village, Terara Sub-District. Poor dug well construction conditions can affect the amount of coliform bacteria contained in the dug well water. The purpose of this study is to identify the construction of dug wells and the content of coliform bacteria in dug well water and determine the relationship between dug well construction and the content of coliform bacteria. This research is analytic with a cross sectional study design. The results were obtained from 11 samples of dug wells which were observed in construction and the coliform content was known that all samples did not requirements as good dug well construction. Coliform content test results showed that as many as 5 dug well water samples did not pass the clean water quality standards. The results of data analysis with the chi-square test variable construction of dug wells with coliform content variable  showed 0,172 > 0,05, then the concluded is the dug well not suitable to use by people in that area as a source of water for daily needs.
UJI EFEKTIVITAS PUPUK ORGANIK CAIR DARI URIN TERNAK SAPI DAN KUDA TERHADAP PERTUMBUHAN VEGETATIF TANAMAN SAWI (Brassica juncea L.)
Authors: Herlinawati Herlinawati , Dharmawibawa Iwan Doddy , Armiani Sucika
Published: March 2020

Mustard Vegetable is an economically valuable vegetable crop, so that community demand for vegetables is increasing. In an effort to meet market needs, mustard production needs to be increased, one of which is by improving the quality of planting media through fertilization. The use of liquid organic fertilizer is faster absorption by plants than solid organic fertilizer. One of the basic ingredients of liquid fertilizer can be using the urine of cattle and horses. This type of research is a pure experiment using a completely randomized design (CRD). The study used 4 treatments 3 replications using liquid organic fertilizer from cow urine and 4 treatments 3 replications using liquid organic fertilizer from horse urine with fertilizer concentrations of 25%, 50% and 100%, with research parameters namely plant height, number of leaves, length leaf, leaf width and wet weight. The technique of data collection is done by observation. The data in this study were analyzed using ANOVA (Analysis of Variance) One Way using SPSS 14 for Windows. The results of research on liquid fertilizer from the urine of cattle and horses significantly affect the rate of growth of mustard plants. The mustard plant has a faster growth rate using liquid fertilizer from cow urine compared to horse urine.
PENTINGNYA PEMBELAJARAN MOBILE, KEARIFAN LOKAL, DAN KEPARIWISATAAN
Authors: Septiawan Firman , Azizah Nur , Gita Paras Purnama , Khery Yusran
Published: March 2020

This study aims to evaluate the application of local wisdom-oriented mobile learning and tourism in West Nusa Tenggara. This type of research is a descriptive study carried out by survey method. The research subjects consisted of 32 students of biology education in semester III and semester V of Mandalika University of Education in the academic year 2019-2020, taken by simple random technique. Data on the application of learning based on local wisdom and tourism was obtained using an observation questionnaire on the application of learning based on local wisdom and tourism in West Nusa Tenggara. The results showed that, the lowest score of aspects of tourism-based learning and local wisdom lies in the lecture aspect starting with the tourism context of West Nusa Tenggara at 53.91 with sufficient categories. While the highest score of lectures was delivered practically related to local products typical of the people of West Nusa Tenggara with a high category of 63.28. Two aspects of learning based on local wisdom and tourism have enough categories namely the lecture aspect starts with the West Nusa Tenggara tourism context to develop knowledge about tourism. While the rest are in the good category.