bluuebunny/crossref_metadata_2025 huggingface dataset:
tRFTars: predicting the targets of tRNA-derived fragments
Authors: Xiao Qiong , Gao Peng , Huang Xuanzhang , Chen Xiaowan , Chen Quan , Lv Xinger , Fu Yu , Song Yongxi , Wang Zhen-Ning
Published: January 2021

Background: tRNA-derived fragments (tRFs) are 14–40-nucleotide-long, small non-coding RNAs derived from specific tRNA cleavage events with key regulatory functions in many biological processes. Many studies have shown that tRFs are associated with Argonaute (AGO) complexes and inhibit gene expression in the same manner as miRNAs. However, there are currently no tools for accurately predicting tRF target genes.Methods: We used tRF-mRNA pairs identified by crosslinking, ligation, and sequencing of hybrids (CLASH) and covalent ligation of endogenous AGO-bound RNAs (CLEAR)-CLIP to assess features that may participate in tRF targeting, including the sequence context of each site and tRF-mRNA interactions. We applied genetic algorithm (GA) to select key features and support vector machine (SVM) to construct tRF prediction models.Results: We first identified features that globally influenced tRF targeting. Among these features, the most significant were the minimum free folding energy (MFE), position 8 match, number of bases paired in the tRF-mRNA duplex, and length of the tRF, which were consistent with previous findings. Our constructed model yielded an area under the receiver operating characteristic (ROC) curve (AUC) = 0.980 (0.977-0.983) in the training process and an AUC = 0.847 (0.83-0.861) in the test process. The model was applied to all the sites with perfect Watson-Crick complementarity to the seed in the 3' untranslated region (3'-UTR) of the human genome. Seven of nine target/nontarget genes of tRFs confirmed by reporter assay were predicted. We also validated the predictions via quantitative real-time PCR (qRT-PCR). Thirteen potential target genes from the top of the predictions were significantly down-regulated at the mRNA levels by overexpression of the tRFs (tRF-3001a, tRF-3003a or tRF-3009a).Conclusions: Predictions can be obtained online, tRFTars, freely available at http://trftars.cmuzhenninglab.org:3838/tar/, which is the first tool to predict targets of tRFs in humans with a user-friendly interface.
Does the gap between health workers’ expectations and the realities of implementing a Performance-Based Financing project in Mali create frustration?
Authors: ZITTI Tony , FILLOL Amandine , LOHMANN Julia , COULIBALY Abdourahmane , RIDDE Valéry
Published: January 2021

Background: Low-and middle-income countries (LMICs) have seen a shift in the health financing architecture in recent years, particularly in Africa. Performance-Based Financing (PBF) is one of these recent initiatives. Motivating health workers is one of the mechanisms through which PBF is assumed to improve the quality of care. Our study therefore offers a unique opportunity to identify and understand how health workers’ expectations related to their experiences of the first cycle of payment of PBF subsidies, and how this affected their motivation and sentiments towards the intervention.Methods: We adopted a qualitative approach using multiple case studies. For our study, we chose three district hospitals (DH 1, 2 and 3) in three health districts (district 1, 2 and 3) among the ten in the Koulikoro region. Our cases correspond to the three DHs. We followed the principle of data source triangulation. The different data sources used are: 53 semi-directive interviews conducted with health workers, following the principle of saturation; field notes and documents relating to the distribution grids of subsidies for each DH. Data was analyzed in a mixed deductive and inductive manner.Results: The results show that the PBF subsidies led to health workers feeling more motivated to perform their tasks overall. Beyond financial motivation, this was primarily due to PBF allowing them to work better. However, respondents perceived a discrepancy between the efforts made and the subsidies received. The fact that their expectations were not met led to a sense of frustration and disappointment. Similarly, the way in which the subsidies were distributed and the lack of transparency in the distribution process led to feelings of unfairness among the vast majority of respondents. The results show that frustrations can build up in the early days of the intervention.Conclusion: The PBF implementation in Mali left health workers frustrated. The short overall implementation period did not allow actors to adjust their initial expectations and motivational responses, neither positive nor negative. This underlines how short-term interventions might not just lack impact, but instil negative sentiments likely to carry on into the future.
Thyroid function and non-alcoholic fatty liver disease in hyperthyroidism patients
Authors: Wang Bairong , Wang Baomin , Yang Yumei , Xu Jing , Hong Mengyang , Xia Mingfeng , Li Xiaomu , Gao Xin
Published: January 2021

Background: Although thyroid function has been demonstrated to be associated with non-alcoholic fatty liver disease (NAFLD) in different population, the prevalence and features of NAFLD in hyperthyroidism have not been reported. The present study aims to investigate the prevalence of NAFLD and association of thyroid function and NAFLD in hyperthyroidism patients.Methods: This cross-sectional study was performed in Zhongshan Hospital, Fudan University, China. A total 117 patients with hyperthyroidism were consecutively recruited from 2014-2015. Thyroid function and other clinical features were measured, liver fat content was measured by color Doppler ultrasonically,NAFLD was defined in patients with liver fat content more than 9.15% . Statistical analyses were performed with SPSS software package version 13.0.Results: The prevalence of NAFLD was 11.97% in hyperthyroidism. Patient with NAFLD had lower free triiodothyronine (FT3) and free thyroxine (FT4) levels than patients without NAFLD (P < 0.05). After adjusting for age, gender, metabolic parameters and inflammation factors, higher FT3 were associated with lower liver fat content (β=－0.072, P=0.009) and decreased odds ratio of NAFLD (OR=0.267, 95%CI 0.087-0.817, P=0.021). Conclusions: FT3 level was negatively associated with the liver fat content in this population. These results may provide new evidence in the role of thyroid hormone on the regulation of liver fat content and NAFLD.
Activation of metabolic and stress responses during subtoxic expression of the type I toxin hok in Erwinia amylovora
Authors: Peng Jingyu , Triplett Lindsay R. , Sundin George
Published: January 2021

Background: Toxin-antitoxin (TA) systems, abundant in prokaryotes, are composed of a toxin gene and its cognate antitoxin. Several toxins are implied to affect the physiological state and stress tolerance of bacteria in a population. We previously identified a chromosomally encoded hok-sok type I TA system in Erwinia amylovora, the causative agent of fire blight disease on pome fruit trees. A high-level induction of the hok gene was lethal to E. amylovora cells through unknown mechanisms. The molecular targets or regulatory roles of Hok were unknown.Results: Here, we examined the physiological and transcriptomic changes of Erwinia amylovora cells expressing hok at subtoxic levels that were confirmed to confer no cell death, and at toxic levels that resulted in killing of cells. In both conditions, hok caused membrane rupture and collapse of the proton motive force in a subpopulation of E. amylovora cells. We demonstrated that induction of hok resulted in upregulation of ATP biosynthesis genes, and caused leakage of ATP from cells only at toxic levels. We showed that overexpression of the phage shock protein gene pspA largely reversed the cell death phenotype caused by high levels of hok induction. We also showed that induction of hok at a subtoxic level rendered a greater proportion of stationary phase E. amylovora cells tolerant to the antibiotic streptomycin. Conclusions: We characterized the molecular mechanism of toxicity by high-level of hok induction and demonstrated that low-level expression of hok primes the stress responses of E. amylovora against further membrane and antibiotic stressors.
ITGA5 is a prognostic biomarker and correlated with immune infiltration in gastrointestinal tumors
Authors: Zhu Hai , Wang Gang , Zhu Haixing , Xu Aman
Published: January 2021

Background: Integrin Subunit Alpha 5 (ITGA5), belongs to the integrin alpha chain family, is vital for promoting cancer cell invasion, metastasis. However, the correlation between ITGA5 expression and immune infiltration in gastrointestinal tumors remain unclear.Methods: The expression level of ITGA5 was detected by Oncomine and Tumor Immune Estimation Resource (TIMER). The association between ITGA5 and prognosis of patients was identified by Kaplan–Meier plotter, Gene Expression Profiling Interactive Analysis 2 (GEPIA2) and PrognoScan. We evaluated the correlation between ITGA5 expression and immune infiltrating level via TIMER. Besides, TIMER, immunohistochemistry (IHC) staining and western blot were used to explore correlations between ITGA5 expression and markers of immune infiltrates cells. Furthermore, we constructed protein-protein interaction (PPI) network and performed functional enrichment by GeneMANIA and Metascape.Results: ITGA5 was generally overexpressed and correlated with worse prognosis in multiple types of gastrointestinal tumors. In addition, ITGA5 expression level was significantly associated with tumor purity and immune infiltration levels of different immune cells in gastrointestinal tumors. Interestingly, immune markers for monocytes, tumor - associated macrophages (TAMs), macrophages 2 (M2) cells and T-helper 2 (Th2) cells were found to be significantly and positively correlated with ITGA5 expression levels in colon and gastric cancer. Results from IHC staining and western blot further proved that markers of Th2 and M2 cell were significantly increased in gastric cancer patients with high ITGA5 expression levels. Lastly, interaction network and function enrichment analysis revealed ITGA5 was mainly involved in “integrin mediated signaling pathway”, “leukocyte migration”, “cell-substrate adhesion”.Conclutions: Our study demonstrated that ITGA5 may act as an essential regulator of tumor immune cell infiltration and a valuable prognostic biomarker in gastrointestinal tumors. Additional work is needed to fully elucidate the underlying mechanisms behind these observations.
What do service providers in Southern Ethiopia say about barriers to using youth-friendly sexual and reproductive health services for adolescents?: Qualitative study 
Authors: Habtu Yitagesu , Kaba Mirgissa , Mekonnen Hussen
Published: January 2021

Background: In Ethiopia, lowest utilization of adolescent friendly sexual and reproductive health services (AFSRHs) is recorded among Sub-Saharan African countries. Little is known why adolescents were not accessing the existing services to the side of healthcare providers. Objective: The aim of this study is to explore contextual perceived and actual barriers to accessing AFSRHs by adolescents in Southern Ethiopia.Methods: Phenomenological study design supplemented with observation was used to explore perceived and actual barriers to accessing AFSRHs in 2020. Criterion sampling was used to select study participants. In-depth interviews with key healthcare providers and non-specialist sexual and reproductive health providers were conducted. Transcribed interviews and observation were imported to Open Code 4.02 for coding, categorizing codes, and creating themes. Finally, barriers to assessing the services were explained using thematic analysis. Results: The study explores contextual barriers to accessing sexual and reproductive health services in five emergent themes. According to providers’ view, barriers include ranging from providers (e.g poor providers’ competency), health facility (e.g. supply constraints and unsupportive environment), adolescents (e.g perceived lack of information and attitude towards SRHs), community (e.g. lack of parental and social support), and broader health system (e.g. poor implementation and multi-sectorial engagement). Conclusion: As to providers, adolescents face multiple barriers to accessing youth friendly sexual and reproductive health services. Healthcare facilities and the health systems should implement varieties of approaches to increase access to the services for adolescents. The existing strategies should be re-evaluated and new interventions at all levels of the healthcare system are needed. Moreover, implementation research is required at system level factors.
Daily, Oral FMT for Longterm Maintenance Therapy in Ulcerative Colitis: Results of a single-center, prospective, randomized pilot study.
Authors: Crothers Jessica Wood , Chu Nathaniel D. , Nguyen Le Thanh Tu , Phillips Magen , Collins Cheryl , Fortner Karen , Rio-Geurra Roxana del , Lavoie Brigitte , Callas Peter , Velez Mario , Cohn Aaron , Elliott Ryan J. , Wong Wing Fei , Vo Elaine , Wilcox Rebecca , Smith Mark , Kassam Zain , Budd Ralph , Alm Eric J. , Mawe Gary M. , Moses Peter L
Published: January 2021

BackgroundFecal microbiota transplantation (FMT) is a promising new strategy in the treatment of Inflammatory Bowel Disease, but long-term delivery systems are lacking. This randomized study was designed as a safety and feasibility study of long-term fecal microbiota transplantation (FMT) in subjects with mild to moderate UC using frozen, encapsulated oral FMT (cFMT). MethodsSubjects were randomized 1:1 to receive FMT induction by colonoscopy, followed by 12 weeks of daily oral administration of frozen encapsulated cFMT or sham therpay. Subjects were followed for 36 weeks and longitudenal clinical assessments included multiple subjective and objective markers of disease severity. Ribosomal 16S bacterial sequencing was used to assess donor-induced changes in the gut microbiota. Changes in T regulatory (Treg) and mucosal associated invariant T (MAIT) cell populations were evaluated by flow cytometry as an exploratory endpoint. ResultsTwelve subjects with active UC were randomized: 6 subjects completed the full 12-week course of FMT plus cFMT, and 6 subjects received sham treatment by colonic installation and longitudinal oral treatment. Chronic administration of cFMT was found to be safe and well-tolerated but home storage concerns exist. Protocol adherence was high, and none of the study subjects experienced FMT-associated treatment emergent adverse events. Two subjects that received cFMT achieved clinical remission versus none in the placebo group (95% CI = 0.38-infinity, p = 0.45). cFMT was associated with sustained donor-induced shifts in fecal microbial composition. Changes in MAIT cell cytokine production were observed in cFMT recipients and correlated with treatment response. ConclusionThese pilot data suggest that daily encapsulated cFMT may extend the durability of index FMT-induced changes in gut bacterial community structure and that an association between MAIT cell cytokine production and clinical response to FMT may exist in UC populations. Oral frozen encapsulated cFMT is a promising FMT delivery system and may be preferred for longterm treatment strategies in UC and other chronic diseases but further evaluations will have to address home storage concerns. Larger trials should be done to explore the benefits of cFMT and to determine its long-term impacts on the colonic microbiome. Trial registration: ClinicalTrials.gov (NCT02390726). Registered 17 March 2015, https://clinicaltrials.gov/ct2/show/NCT02390726?term=NCT02390726&draw=2&rank=1.
Prevalence of Depression Symptoms and Associated Sociodemographic and Clinical Correlates among Syrian Refugees in Lebanon
Authors: Naal Hady , Nabulsi Dana , Arnaout Nour El , Abdouni Lina , Dimassi Hani , Harb Ranime , Saleh Shadi
Published: January 2021

Background: Since the outbreak of the Syrian war in 2011, close to 6 million Syrian refugees have escaped to Syria’s neighbouring countries, including Lebanon. Evidence suggests rising levels of mental health disorders among Syrian refugee populations. Yet, to the best of our knowledge, large-scale studies addressing the mental health of adult Syrian refugees in Lebanon are lacking.Aims: We examined the prevalence of depression symptoms, which represent a common and debilitating mental health disorder among Syrian refugee populations in Lebanon, along with their sociodemographic and clinical correlates.Methods: A cross-sectional survey design was conducted as part of a collaborative project-“Sijilli”- led by the Global Health Institute at the American University of Beirut (Beirut, Lebanon) across 4 informal tented settlements for refugees (Beirut, Bekaa, North, South) in Lebanon among adult Syrian refugees (≥18), over a period extending from 2018 to 2020. The survey inquired about participants’ sociodemographic and clinical characteristics, and screened participants for symptoms of depression through sequential methodology using the Patient Health Questionnaire (PHQ-2 and PHQ-9).Results: A total of 3255 adult Syrian refugees were enrolled in the study. Of those refugees, 46.73% (n=1521) screened positive on the PHQ-2 and were therefore eligible to complete the PHQ-9. In the entire sample (n=3255), the prevalence of moderate to severe depression symptoms (PHQ-2 ≥2 and then PHQ-9 ≥10) was 22% (n=706). Further analyses indicate that being ≥45 years of age (OR 1.61, 95% CI 1.13-2.30), a woman (OR 1.34, 95% CI 1.06-1.70), widowed (OR 2.88, 95% CI 1.31-6.32), reporting a neurological (OR 1.73, 95% CI 1.15-2.60) or a mental health condition (OR 3.98, 95% CI 1.76-8.97) are major risk factors for depression.Conclusion: Our study suggests that an estimated one in four Syrian refugees in Lebanon shows moderate to severe depression symptoms, and our findings have important public health and clinical implications on refugee health. There is a need to enhance screening efforts, to improve access and referral to mental health services, and to improve post-migration factors among Syrian refugees in Lebanon.
CALM1 promotes progression and dampens chemosensitivity to EGFR inhibitor in esophageal squamous cell carcinoma
Authors: Liu Tao , Han Xiujuan , Zheng shutao , Liu Qing , Tuerxun Aerziguli , Zhang Qiqi , Yang Lifei , Lu Xiaomei
Published: January 2021

Background: Calmodulin1 (CALM1) has been identified as one of the overexpression genes in a variety of cancers and EGFR inhibitor have been widely used in clinical treatment but it is unknown whether CALM1 and epidermal growth factor receptor (EGFR) have a synergistic effect in esophageal squamous cell carcinoma (ESCC). The aim of the present study was to explore the synergistic effects of knock-out CALM1 combined with EGFR inhibitor (Afatinib) and to elucidate the role of CALM1 in sensitizing the resistance to Afatinib in ESCC. Method: Immunohistochemistry (IHC) and qRT-PCR were used to examine the expression of CALM1 and EGFR in ESCC tissues. Kaplan–Meier survival analysis was used to analyze the clinical and prognostic significance of CALM1 and EGFR expression in ESCC. Furthermore, to evaluate the biological function of CALM1 in ESCC, the latest gene editing technique CRISPR/Cas9（Clustered regularly interspaced short palindromic repeats）was applied to knockout CALM1 in ESCC cell lines KYSE150, Eca109 and TE-1. MTT, flow cytometry, Transwell migration, scratch wound-healing and colony formation assays were performed to assay the combined effect of knock-out CALM1 and EGFR inhibitor on ESCC cell proliferation and migration. In addition, nude mice xenograft model was used to observe the synergistic inhibition of knock-out CALM1 and Afatinib.Results: Both CALM1 and EGFR were found to be significantly over-expressed in ESCC compared with paired normal control. Over-expressed CALM1 and EGFR were significantly associated with clinical stage, T classification and poor overall prognosis, respectively. In vitro, the combined effect of knock-out CALM1 mediated by the lentivirus and EGFR inhibitor was shown to be capable of inhibiting the proliferation, inducing cell cycle arrest at G1/S stage and increasing apoptosis of KYSE-150 and Eca109 cells; invasion and migration were also suppressed. In vivo, the results of tumor weight and total fluorescence were markedly reduced compared with the sgCtrl-infected group and sgCAML1 group.Conclusion: Our data demonstrated that knock-out of CALM1 could sensitize ESCC cells to EGFR inhibitor, and it may exert oncogenic role via promotion of EMT. Taken together, CALM1 may be a tempting target to overcome Afatinib resistance.
Investigating Metalinguistic Written Corrective Feedback Focused on EFL Learners' Discourse Markers Accuracy in Mobile-mediated Context
Authors: Pourdana Natasha , Nour Payam , Yousefi Fariba
Published: January 2021

Among a growing body of research that examined the contradictory role of written corrective feedback (WCF) in development of L2 writing accuracy, this study investigated the possible impact of focused metalinguistic WCF on discourse markers (DMs) in writing performance of an intact group of 42 Iranian English as a Foreign Language (EFL) learners over an eight-week period. In an authentic, situated, and personalized learning platform, giving and receiving WCF were made possible only through the mobile-mediated application of WhatsApp. Before participants wrote on selected elicitation topics, they had taken part in a 2004 version of Oxford Preliminary Test in order to be screened for their initial differences in writing performance. After receiving metalinguistic WCF on their scripts, participants were required to work on the coded feedback and try to eliminate the DM errors in their revised writing assignment. After collecting the scripts over an eight-week period, the content of written assignment was thematically analyzed using NVivo 21 Software for the additive, adversative, causal and temporal DMs, following Halliday and Hasan’s (1976) typology. In a convergent mixed-methods design, the content analysis of the qualitative data showed a larger distribution of additive DM than adversative, causal, and temporal DMs in all participants’ written scripts. Exploring the possible impact of metalinguistic WCF on improving the DMs accuracy, analysis of the frequency count data with Statistical Package for the Social Sciences (SPSS) multivariate Chi-square test reported the fluctuation and unsystematic patterns of distribution for four types of DMs with no sign of significant long-term improvement in DMs accuracy after receiving metalinguistic WCF. These findings implied further research on practicing alternative WCF strategies focused on variety of error types in actual and virtual L2 writing environments.
Comprehensive analysis of lumbar disc degeneration and autophagy-related candidate genes, pathways, and targeting Drugs
Authors: Xu Wei-long , Zhao Yan
Published: January 2021

Background: Lumbar disc degeneration (LDD) is a major pathological process implicated in low back pain. At present, the research in the fields of spinal surgery has highlighted the complex mechanisms underlying LDD, with autophagy being considered as one of the important processes involved.Objectives: This study was designed to identify the potential key genes and molecular pathways associated with LDD and autophagy using computational tools and publicly available data, and to explore drugs targeting the relevant genes associated with LDD and autophagy.Materials and Methods: We used text mining to detect the LDD and autophagy-associated genes, and the intersection of the two gene sets was selected for gene ontology analysis using the DAVID program. We then constructed protein–protein interaction networks, followed by a functional enrichment analysis, from which we obtained three significant gene modules. Finally, the final list of genes was queried against the Drug Gene Interaction database to find drug candidates targeting relevant genes associated with LDD and autophagy.Results: Our analysis identified 72 genes common to both the “LDD” and “Autophagy” text mining concepts. Gene enrichment analysis yielded three significant gene modules (22 genes), which represent four significant pathways and could be targeted by 32 Food and Drug Administration (FDA)-approved drug molecules, and identified the drug–gene interactions. Conclusion: In summary, we presented a method to explore the potential key genes, molecular pathways and candidate drugs associated with LDD and autophagy. As a result, in this method, we identified a total of 22 potential genes, four significant pathways and 32 candidate drugs, which could provides a basis for new trials and the development of novel targeted therapies as potential treatments for LDD.
Rapid ethnographic assessment for potential anti-malarial mass drug administration in an outbreak area of Santo Domingo, Dominican Republic
Authors: Keys Hunter , Ureña Keyla , Reyes Jhefres , Bardosh Kevin , Pell Christopher , Puello Jose , Blount Stephen , Noland Gregory S.
Published: January 2021

Background In the Dominican Republic, a recent outbreak of malaria in the capital, Santo Domingo, threatens efforts to eliminate the disease. Mass drug administration (MDA) has been proposed as one strategy to reduce transmission. The success of MDA is contingent upon high levels of acceptance among the target population. To inform the design of future MDA campaigns, this rapid ethnographic assessment examined malaria-related knowledge and attitudes toward malaria MDA among residents of a transmission focus in Santo Domingo. Methods In October 2019, a rapid ethnographic assessment was conducted in the Los Tres Brazos transmission focus, which had not previously received MDA. National malaria programme staff conducted 61 structured interviews with key informants, recorded observations, and held 72 informal conversations. Using a grounded theory approach, data were analysed during three workshop sessions with research team members. Results Among those who had heard of malaria in the structured interviews (n=39/61; 64%), understanding of the disease was largely based on personal experience from past outbreaks or through word-of-mouth. Community health workers (promotores) were trusted for health information and malaria diagnosis more so than professional clinicians. No participant (0%) was familiar with malaria MDA. After learning about MDA, almost all study participants (92%) said that they would participate, seeing it as a way to care for their community. Reasons for not participating in future MDA included not trusting drug administrators, feeling reluctant to take unprescribed medicine, and fear of missing work. Additional identified challenges to MDA included reaching specific demographic groups, disseminating effective MDA campaign messages, and managing misinformation and political influence. Conclusion Residents appear accepting of MDA despite a lack of prior familiarity. Successful MDA will depend on several factors: fostering relationships among community-based health workers, clinicians, community leaders, and others; developing clear health messages that use local terms and spreading them through a variety of media and social networks; and contextualizing MDA as part of a broader effort to promote community health.
Neonatal care practices in Buikwe District, Uganda: A qualitative study
Authors: Roed Marte Bodil , Engebretsen Ingunn Marie Stadkleiv , Mangeni Robert
Published: January 2021

Background: Sub-Saharan Africa is the region with the highest neonatal mortality rate, with Uganda reporting 20 deaths per 1000 live births. The Uganda Clinical Guidelines (UCG) from 2016 have detailed descriptions on care for mothers and their newborns during pregnancy, delivery and the post-partum period. The objective of the study was to identify provider and user perspectives regarding the knowledge of and adherence to the UCG recommendations in aspects of delivery and newborn care, both in cases of normal as well as complicated births. Methods: The study used qualitative methods with data collection from participant observations, interviews with key-informants and focus group discussions. Malterud’s Systematic Text Condensation (STC) was used for analysis. Results: The study found low knowledge about the UCG among the health workers. Various discrepancies between performed hands-on-procedures and the UCG were found related to neonatal care practices, including low use of partograms, uncertainty around timing for cord clamping, routine oronasopharyngeal suction of newborns and inadequate implementation of skin-to-skin care. Conclusions: Continued focus on systemic strategies for further implementation of the UCG is recommended.
Perlindungan Hukum Terhadap Pemegang Polis Asuransi Jiwa
Authors: Wasita Agus
Published: January 2021

Most of family in Indonesia do not have insurance to reserve enough fund that will provide financial stability to protect themself and their families . As a consequence, in the event of accident, family will go bankrupt because they take short cut sells all asset to overcome accident that happened. Base survey of some insurance companies, as high as 86 percents of our society are not yet have protected insurance because of misperception, l a large part of people not feel require insurance . Despite that, lack of understanding makes society have in mind that insurance as burden and viewed as expensive product that bring less benefit for them. Other Constraint is lack of information for insurance client in course of claim to get its rights . insurance claim process frequently become animus process between insurance client and insurance company even sometimes their dispute possibility continues become lawsuit which is wasting time and energy for both of them . Lack of understanding to insurance law makes society sometimes use the wrong ways to solve their insurance lawsuit. This research intention to returns the society perception to the correct ways.This research is part of the legal research literature by examining the library materials or the so-called normative legal research.The results showed that the country has made political efforts to protect the legal right of citizens with regard to insurance, but indeed such cases other law enforcement efforts is still a chore government never resolved.
Pengaruh Pembelajaran Mata Kuliah Character Building (CB) Self Development Terhadap Perilaku Mahasiswa Sastra China Angkatan 2010 Universitas Bina Nusantara Jakarta
Authors: Sriyanto Hari
Published: January 2021

Learning Character Building / Character Building (CB): Self Development is a compulsory subject taught to students of Bina Nusantara University in semester 1 or semester 2. This study aims to determine and examine the effect of ability to know yourself, ability to accept yourself , and attitudes simultaneously and partially towards the behavior of Chinese Literature Force students in 2010 at Bina Nusantara University after attending and receiving the Character Building (CB) course I: Self Development. The sample in this study amounted to 70 students of Chinese Literature in 2010. This research is an explanatory research (Explatanatory Research) and also correlational research to see the relationship between variables. The data in this study are primary data obtained from questionnaires given to respondents directly. The results obtained indicate that the ability to know oneself, the ability to accept oneself, and attitudes have a significant and simultaneous influence on the behavior of Chinese Literature students at Bina Nusantara University in 2010.
Form Follows Culture: Symbolic Feng Shui Logo Design in the Greater China Region
Authors: SER ShawHong
Published: January 2021

The visual identity of a logo has always been one of the major means of expression of social values, and cultural preferences in a particular society. Hence, each area and region logo’s design aesthetic is a style characterized by a particular cultural influence that introduces its principles and canons. Accordingly, a logo is not just a representation of a company or business, in order to fully serve its purpose, the logo representation must illustrate what the company does as well as be able to echo with the social, cultural and geographical features of the targeted region. In this paper, to respond to the research scholarly interest in the cultural influences on design, the researcher has made an attempt to study the influence of Feng Shui on logo design in the Greater China region. Based on an in-depth visual-based survey on banks’ logo design in the Greater China region, the author identified in this paper one unique design characteristic, namely Symbolic Feng Shui logo design. The result showed that (1) there is substantial cultural values and preference for the logo with the influence and application of Feng Shui. (2) Logos based on concepts and forms (particularly ancient Chinese coins) found in Feng Shui were the most preferred visual representation used by banks in the Greater China region. (3) The Symbolic Feng Shui logo as a unique design language has developed into its distinctive style. It is hoped that this paper will provide insights into an understanding of the impact of traditional culture on modern design, particularly on Feng Shui culture-inspired logo design in the Greater China region.
Faktor-Faktor yang Mempengaruhi Underprice Penawaran Saham Perdana di Indonesia
Authors: Hartanto Hartanto
Published: January 2021

The characteristics of an Initial Public Offering (IPO) is an important factor for several parties in achieving their goals, for example, for companies (which release the shares) will have a projection of the capital to be obtained, as well as for underwriters and investors to maximize their profits. Lack of knowledge of the character of the IPO, can cause problems, especially the potential loss to the several parties. This study aims to explore the character of IPO in Indonesia, especially the occurrence of Underprice and what are the factors that influence it. This study uses prospectus data of companies that conduct IPOs on the JSX, data library and websites that have the necessary data, the period 1995 to 2001. The results show that the Underprice phenomenon does indeed occur on IPOs on the JSX and most of the variables tested have an influence underprice occurrence. This study provides several suggestions including the need for the addition of more various variable.
Penentuan Faktor-Faktor yang Mempengaruhi Tingkat Fertilitas Di Indonesia Tahun 2017 Dengan Metode Multiple Classification Analysis (Analisis Data SDKI 2017)
Authors: Maharani Vivy , Ramadhanty Annisa Putri , Putra Galang Madya , Pratama Iqbal Mukti , Yuhan Risni Julaeni
Published: January 2021

Fertility is the ability to produce offspring associated with female fertility. The desired condition is for the population to grow in balance as a prerequisite for achieving a population without growth, where fertility, mortality rates are declining, and distribution is more evenly distributed. To achieve a Balanced Growing Population Condition (PTS), a total fertility rate (TFR) of 2.1 per woman is expected in 2015. However, based on the results of the 2017 IDHS fertility rate in Indonesia is 2.4. This has not met the desired conditions to achieve the Balanced Growing Population (PTS) condition. For this problem, it is necessary to do further research to find out the factors that affect the level of fertility or the number of children born to women. In this study, researchers used the Multiple Classification Analysis (MCA) method to determine the factors that influence the number of births. The results and discussion show that a mother who knows her ovulation cycle and / or lives in a city has an average number of children who are smaller than a mother who does not know her ovulation cycle and / or resides in the village. This happens because a mother who knows her ovulation cycle is more able to control the incidence of pregnancy compared to a mother who does not know her ovulation cycle.
Suitability of Text-Based Communications for the Delivery of Psychological Therapeutic Services to Rural and Remote Communities: Scoping Review
Authors: Dwyer Anne , de Almeida Neto Abílio , Estival Dominique , Li Weicong , Lam-Cassettari Christa , Antoniou Mark
Published: January 2021

Background

People living in rural and remote areas have poorer access to mental health services than those living in cities. They are also less likely to seek help because of self-stigma and entrenched stoic beliefs about help seeking as a sign of weakness. E-mental health services can span great distances to reach those in need and offer a degree of privacy and anonymity exceeding that of traditional face-to-face counseling and open up possibilities for identifying at-risk individuals for targeted intervention.

Objective

This scoping review maps the research that has explored text-based e-mental health counseling services and studies that have used language use patterns to predict mental health status. In doing so, one of the aims was to determine whether text-based counseling services have the potential to circumvent the barriers faced by clients in rural and remote communities using technology and whether text-based communications, in particular, can be used to identify individuals at risk of psychological distress or self-harm.

Methods

We conducted a comprehensive electronic literature search of PsycINFO, PubMed, ERIC, and Web of Science databases for articles published in English through November 2020.

Results

Of the 9134 articles screened, 70 met the eligibility criteria and were included in the review. There is preliminary evidence to suggest that text-based, real-time communication with a qualified therapist is an effective form of e-mental health service delivery, particularly for individuals concerned with stigma and confidentiality. There is also converging evidence that text-based communications that have been analyzed using computational linguistic techniques can be used to accurately predict progress during treatment and identify individuals at risk of serious mental health conditions and suicide.

Conclusions

This review reveals a clear need for intensified research into the extent to which text-based counseling (and predictive models using modern computational linguistics tools) may help deliver mental health treatments to underserved groups such as regional communities, identify at-risk individuals for targeted intervention, and predict progress during treatment. Such approaches have implications for policy development to improve intervention accessibility in at-risk and underserved populations.
Usability, Perceived Usefulness, and Shared Decision-Making Features of the AFib 2gether Mobile App: Protocol for a Single-Arm Intervention Study
Authors: Kapoor Alok , Andrade Andreza , Hayes Anna , Mazor Kathleen , Possidente Carl , Nolen Kim , Hegeman-Dingle Rozelle , McManus David
Published: January 2021

Background

The Centers for Disease Control and Prevention has estimated that atrial fibrillation (AF) affects between 2.7 million and 6.1 million people in the United States. Those who have AF tend to have a much higher stroke risk than others. Although most individuals with AF benefit from anticoagulation (AC) therapy, a significant majority are hesitant to start it. To add, providers often struggle in helping patients negotiate the decision to start AC therapy. To assist in the communication between patients and providers regarding preferences and knowledge about AC therapy, different strategies are being used to try and solve this problem. In this research study, we will have patients and providers utilize the AFib 2gether app with hopes that it will create a platform for shared decision making regarding the prevention of stroke in patients with AF receiving AC therapy.

Objective

The aim of our study is to measure several outcomes related to encounters between patients and their cardiology providers where AFib 2gether is used. These outcomes include usability and perceived usefulness of the app from the perspective of patients and providers. In addition, we will assess the extent and nature of shared decision making.

Methods

Eligible patients and providers will evaluate the AFib 2gether mobile app for usability and perceived usefulness in facilitating shared decision making regarding understanding the patient’s risk of stroke and whether or not to start AC therapy. Both patients and providers will review the app and complete multiple questionnaires about the usability and perceived usefulness of the mobile app in a clinical setting. We will also audio-record a subset of encounters to assess for evidence of shared decision making.

Results

Enrollment in the AFib 2gether shared decision-making study is still ongoing for both patients and providers. The first participant enrolled on November 22, 2019. Analysis and publishing of results are expected to be completed in spring 2021.

Conclusions

The AFib 2gether app emerged from a desire to increase the ability of patients and providers to engage in shared decision making around understanding the risk of stroke and AC therapy. We anticipate that the AFib 2gether mobile app will facilitate patient discussion with their cardiologist and other providers. Additionally, we hope the study will help us identify barriers that providers face when placing patients on AC therapy. We aim to demonstrate the usability and perceived usefulness of the app with a future goal of testing the value of our approach in a larger sample of patients and providers at multiple medical centers across the country.

Trial Registration

ClinicalTrials.gov NCT04118270; https://clinicaltrials.gov/ct2/show/NCT04118270

International Registered Report Identifier (IRRID)

DERR1-10.2196/21986
Позднесарматские погребения курганной группы Кермен Толга
Authors:   Kalmyk Scientific Center of the RAS, Burataev Evgeny G.
Published: January 2021

The article presents the materials of the archaeological excavation work of the Kermen Tolga Mound Group in 1979. The site is located on the territory of the Sarpinskiy lowlands in the area of concentration of the monuments of Sarmatian culture. The study takes into account all the burial materials that have characteristics of the late Sarmatian culture, the specific features of which are the occurrence of north orientation of the buried and the custom of unnatural deformation of the head. Along with these specific features in the mound complex were found burials that have south orientation which undoubtedly date back to the I century AD — mid-Sarmatian period. However, in our case these burials have the common characteristics of the further — post Sarmatian culture that allows us to speak about the gradual transition of the Sarmatian culture and the influence of the outsider post Sarmatian tribes on the mid-Sarmatian traditions in this region.
Этнопоэтические константы как показатель текстовой репрезентации ключевых звеньев сказочного нарратива (на примере синьзян-ойратской и калмыцких версий сказки об Ёёт Мерген Темне)
Authors:   Kalmyk State University named after B.B. Gorodovikov, Khabunovа Evdokia E.
Published: January 2021

The article discusses the text realization of the ethnopoetic constants in the fairytale narrative of the Xinjiang Oirats and Russian Kalmyks. The study is based on the theory of literary constants of V. M. Gatsak that are defined as “manifestational-verbal matter with ‘core’ overarching words and word-combinations”. The analysis covers national versions (Xinjiang Oirat and Kalmyk) of the fairytale “Yoot Mergen Temen” recorded at different times from different storytellers on the territories of the Xinjiang-Uighur Autonomous Region of PRC and the Republic of Kalmykia in the Russian Federation. It is pointed out that constants help to identify the key links in the structural and content model of the fairytale narrative and determine the ethnic specific character of the folklore pieces of work.
Correlation of Bioelectrical Impedance With Freshness Quality Attributes of Beef Longissimus Lumborum Steaks
Authors: Najar-Villarreal Francisco , Boyle Elizabeth A. E. , Vahl Christopher I. , Kang Qing , Houser Terry A. , Gonzalez John M. , Amamcharla Jayendra , Vega Daniel , Kastner Justin J. , Cox M. Keith
Published: January 2021

The quality attributes of beef longissimus lumborum during 15 d of retail display were assessed using surface bioelectrical impedance analysis (S-BIA) and internal bioelectrical impedance analysis (I-BIA). Beef loins (N = 18) were obtained from 3 commercial processors with 3 postmortem (PM) ages (27, 34, and 37 d). Loins were fabricated into twelve 2.54-cm-thick steaks, subdivided into 6 consecutively cut pairs, and randomly assigned to one of 6 display days (DD): 0, 3, 6, 9, 12, or 15. Steaks were assessed for S-BIA and I-BIA. Three locations were analyzed within each steak: top, middle, and bottom. Microbiological analysis, BIA, pH, instrumental color, proximate composition, and lipid oxidation were measured. There was a location × PM day × DD interaction (P < 0.05) for longissimus lumborum steaks for S-BIA. Among all 3 locations, steaks aged 27 d had higher (P < 0.05) S-BIA values on day 9 and 12 than steaks aged 34 and 37 d. There were no location × PM day × DD or two-way interactions (P > 0.05) for I-BIA. Display day affected (P < 0.05) all instrumental color data regardless of PM aging times. Among all PM aging times, steaks aged 27 d were 13% and 7% higher for a* and b* , respectively, compared with 34 and 37 d PM. There was a PM day × DD interaction (P < 0.05) for aerobic plate counts (APC). From day 0 and 9 of display, APC of steaks aged 27 d PM were 1 to 2.0 log colony-forming units/cm 2 lower than steaks aged 34 and 37 d. Quality attributes, including a*, b* , APC, and thiobarbituric acid reactive substances, were correlated (r = 0.70, − 0.64, − 0.56, and 0.69, respectively) with S-BIA. Overall, BIA values increased on aerobically packaged longissimus lumborum steaks and were correlated with various freshness quality parameters.
Peran gaya pengasuhan dan penanganan secara religius terhadap resiliensi pada remaja dengan HIV/AIDS di DenpasarBali
Authors: Darmawan Dinda Nabilla , Savitri Jane , M.Tj Jacualine
Published: January 2021

Objektif:Tujuan dari penelitian ini adalah mengetahui peran parenting style dan religious coping secara bersama-sama maupun parsial terhadap resiliency pada remaja dengan HIV/AIDS di Denpasar-Bali. Penelitian ini menggunakan metode kuantitatif dengan 103 subjek remaja dengan HIV/AIDS di Denpasar-BaliMetode: Penelitian menggunakan desain kuantitatif dengan 103 responden remaja penderita HIV/AIDS yang tinggal di DenpasarBali. Data penelitian diolah menggunakan multiple regression dan linear regression. Temuan: Berdasarkan analisis yang dilakukan dalam penelitian ini, diketahui bahwa: parenting style Ayah dan religious coping bersama-sama berperan terhadap resiliency (ρ < .05, R2 = 0,384); parenting style Ibu dan religious coping bersama-sama memiliki peran terhadap resiliency (ρ < .05, R2 = 0,365).Kesimpulan:Perhitungan secara parsial diperoleh hasil bahwa parenting style authoritative baik Ayah maupun Ibu, parenting style Ibu authoritarian, parenting style Ayah dan negative religious coping, parenting style Ibu dan positive religious coping, serta parenting style Ibu dan negative religious coping yang memiliki peran terhadap resiliency, sedangkan variabel lain tidak berperan terhadap resiliency.