bluuebunny/crossref_metadata_2025 huggingface dataset:
Non-current assets held for sale and discontinued operations: an analysis in the level of evidence and the characteristics of publicly traded Brazilian companies
Authors: Silva Andressa Fernanda da , Souza Maíra Melo de
Published: July 2022

Purpose: The objective of this research is to analyze the level of disclosure and the characteristics of publicly traded Brazilian companies in relation to non-current assets held for sale and discontinued operations.

Methodology: To analyze the level of disclosure, a checklist was created based on CPC 31 (2009). This study is classified as documentary, considering that the Notes to the Financial Statements, the Balance Sheet and the Statement of Income for the Year of the companies included in the sample were analyzed. The problem approach was qualitative. The sample consists of all companies in Brazil, Bolsa, Balcão (B3) that presented non-current assets held for sale (NCAHS) and / or discontinued operations (DO) in 2018, which corresponds to 67 companies divided into 10 operating sectors. The characteristics analyzed were: sector of activity, corporate governance, profitability, auditing company, and shares are traded on the New York Stock Exchange (NYSE).

Results: The results suggest that companies that fall under the New Market, have negative profitability and trade shares on the NYSE tend, on average, to perform a higher level of disclosure of  NCAHS and DO. The sectors with the highest concentration of NCAHS and DO were Industrial Goods and Cyclic Consumption, both comprising 16 companies out of 67 in the sample. The nature of NCAHS that stood out the most were the subsidiaries, with 49% representativeness. It was observed that companies still need to improve their disclosure, as the sample average was 44%.

Contributions of the Study: The realization of the present investigation contributes in the sense that the accounting practice pertaining to NCAHS and DO is relatively recent in Brazil and many academics may still have doubts about the subject, considering that the accounting pronouncement CPC 31 brought new disclosure procedures. In this sense, this research contributes towards presenting the way in which Brazilian public companies are showing NCAHS and DO in an updated context, demonstrating that they need to improve the level of information disclosed to fully comply with CPC 31.
Influence of operational levels of corporate governance on earnings management in companies listed on B3
Authors: Trocz Pedro Junior de Oliveira , Zanchet Aládio , Asta Denis Dall , Fiirst Clóvis
Published: July 2022

Purpose: To analyze the influence of operational levels of corporate governance on earnings management in companies listed on B3.

Methodology: Descriptive research with a documentary procedure and a quantitative approach was adopted. The sample consisted of 207 companies listed on B3, which are classified in the operational levels of corporate governance. Data were collected through Economática® from 2013 to 2018 and, subsequently, the model developed by Kang and Sivaramakrishnan (1995) was used. To estimate the result management, the software SPSS, LhStat and Excel were used.

Results: The results show that in the result management aspect there is not a trend or an evolutionary line, that the segments which require higher corporate governance standards, companies have accounting choices to manage less results, or, that in the segments with lower corporate governance requirements, companies have accounting choices to manage more results. After all, the operational levels that have the best corporate governance concepts, do not negatively influence the practice of earnings management, as well as, the operational levels that do not have the best concepts, do not positively influence the earnings management practice.

Contributions of the Study: The study brought contributions to the corporate sphere, addressing the promotion of governance as a mechanism for transparency in companies accountability in the aspect of earnings management. This allows users to infer the quality of accounting information disclosed by B3. Likewise, contributions in the academic sphere when analyzing accounting choices directly from companies' accounting statements, bringing the theory discussed in the academy closer to the associations reality.
The relation between the adherence of integrated reporting to the IIRC framework and economic performance
Authors: Romão Gabriel , Ribeiro Cíntia de Melo de Albuquerque , Vieira Neto Júlio
Published: July 2022

Purpose: Analyzing the adherence of the Integrated Reports of a sample composed by three Brazilian companies to the IIRC (International Integrated Reporting Council) Framework. Also, understanding the quality contribution of these reports to the generation of economic performance for the adopting companies.

Methodology: The companies were selected from the IIRC database. Using the method presented by Kiliç and Kuzey (2018) as a reference, a Disclosure Index model was adapted, through the content analysis technique, to measure the level of adherence of the Reports to the Framework. After calculating the Disclosure Index, the Coefficient of Variation of the companies' liquidity and solvency ratios and the macroeconomic performance of the researched period were analyzed, aiming to verify whether the Integrated Reports adhering to the Framework are associated with the economic performance of those companies.

Results: The results indicate that it is not possible to state that the high levels of adherence to the Framework are associated with the economic performance of companies. The Coefficient of Variation calculation of the financial indexes during the publication period of the Integrated Reports does not present a better result when compared to the period prior to these publications.

Contributions of the Study: Recent research on the topic of Integrated Reporting does not show a relationship between compliance with publications and the economic performance of Brazilian companies. Thus, this study proves to be relevant when researching the content of the Integrated Reports published by Brazilian companies and the relationship of this information with economic performance, verifying whether the Integrated Reports fulfill the promise of delivering economic benefits to the model's adopters.
Value relevance of the new operating income: evaluation of the exposure draft 2019/07
Authors: Lima Rummenigue Farias , Costa Luiz Ricardo da , Rodrigues Jomar Miranda
Published: July 2022

Purpose: To analyze the value relevance of the new operating result proposed by ED/2019/07 in Brazilian companies in relation to the gaap and non-gaap measure, assessing the relevance of the new operating result associated with the market value of companies.

Methodology: We used economic and financial data, available at Economatica, from 149 companies from the 9 economic sectors of B3, which had the annual information necessary to carry out the study in the period from 2010 to 2019. For data analysis, we used a restatement of the current income statement, to assess the new operating income provided for in the Exposure Draft. To assess value relevance, the model by Ohlson (1995) was used, which allows evaluating the explanatory power of the R2 of the regression.

Results: The results of the analyzes suggest that, for the analyzed companies, the value relevance of New Operating Income (R2=0.4439) is higher than EBITDA (R2 = 0.4321), followed by Net Income (R2 = 0.4094). Such results show that the New Operating Result has greater explanatory power for the companies' market value. So, the results corroborate the conclusions of Barton et al. (2010) in which the Operating Result and EBITDA have greater value relevance than the gaap measure and, consequently, a greater association with stock returns.

Contributions of the Study: The study provides empirical evidence on the possible impacts of the new income statement, with practical implications, and on how the change in the presentation of the income statement can impact the predictability of actions. In addition to theoretical and practical contributions, as it is a future standard that, it seems, will be implemented in the coming years, this research can contribute to accounting professionals, auditors and regulatory bodies in understanding the benefits and impacts of the proposed changes.
Analysis of the capital structure and debt heterogeneity of publicly traded companies in the industrial and agribusiness sector
Authors: Marongio Antonio Flávio Quintanilha , Magnani Vinícius Medeiros , Gatsios Rafael Confetti
Published: July 2022

Purpose: In recent years, the subsidized credit provided by the Brazilian government to some sectors of the economy through financing lines, such as FINAME, FIDIC, from BNDES, may have resulted in a reduction in the costs of the capital structure. Thus, the purpose of this work is to verify if there was a reduction in the cost of capital of publicly traded companies in two important economic sectors, the industrial sector and sectors related to agribusiness.

Methodology: Information regarding financing sources, financing amount, currency and interest rates were collected from the Explanatory Notes to the financial statements of 84 publicly traded companies and used to calculate the weighted average cost of capital of the financing sources at subsidized rates and not subsidized.

Results: The results show that loans with subsidized rates present a great variability in the participation of loans with subsidized rates in the composition of financing of companies, but showing, on average, a low percentage in the composition of indebtedness, and that the effective rates averages of subsidized loans may be higher than the average effective rates of non-subsidized loans, suggesting that subsidized credits, in proportion to which they have been used to compose the financing, may not play a relevant role in reducing the costs of the capital structure of companies

Contributions of the Study: This work contributes to the identification of relevant factors that explain how companies determine their capital structure, providing administrators with indications on which factors are preponderant in the practical performance of companies' capital structure policy.
Brazilian emergency benefit: implementation and control to compared to Lowi’s distributive theory
Authors: Fraga Marinette Santana , Ferreira Cláudia Aparecida Avelar , Teodósio Armindo dos Santos de Sousa , Yoshitake Mariano , Motta Verônica Macário de Oliveira
Published: July 2022

Purpose: The present study aims to evidence the origin of resources, the implementation and distribution processes of the emergency benefit destined to the popular classes, comparing with Lowi's distributive theory, and justify the control and accountability.

Methodology: A literature review was conducted regarding Lowi's approach to distributive theory and documentary research in federal executive transparency sites for the construction of this theoretical essay.

Results: The results point to the existence of a mere mutation of the origins of resources in education and health, for the Ministry of Citizenship leaving doubts about whether there was effectiveness of investments. The emergency benefit immediately serves the most disadvantaged people but does not repair the permanent damage of the trajectory of vulnerability and sub citizenship of the population of the popular classes. The control action and accountability of resources by the Federal Court of Auditors shows that there was a lack of focus on social policy, as predicted by Lowi's distributive theory (Marcuso & Moreira, 2013).

Contributions of the Study: In the academic and scientific sphere, this study contributes to the debate of Lowi's distributive theory applied in contingency situations, such as in the context of covid's pandemic 19. For society, its contributions permeate the need for more transparent, reliable information and greater comprehensibility of the use and origins of public resources to avoid budgetary manipulations. And the need for intervention of controlling institutions to ensure the proper use of the public office.
Professor perception on the applicability of PBL in accounting education: challenges and limitations
Authors: Morais Maria Auxiliadora de Oliveira , Gomes Hellen Bomfim , Lima Diogo Henrique Silva de , Araujo Aneide Oliveira , Martins Joana Darc Medeiros
Published: July 2022

Objective: Analyze the perception of accounting professors at public HEIs about the use of the Problem-Based Learning (PBL) methodology in accounting education.

Methodology: Semi-structured interviews were carried out with the analysis units composed of nine professors from undergraduate courses in accounting at public universities located in Rio Grande do Norte. The information obtained in the interviews was transcribed and, subsequently, went under the coding process, carried out with the aid of the ATLAS.ti®️ software, enabling the identification of the units of meaning contained in the interviewees' discourse, leading to a content analysis. A data triangulation was carried out using the course plans of the subjects taught by the interviewees along with the information disclosed in the interviews.

Results: Based on the results obtained through the interviews, interviewees consider that problem-based learning is an applicable method to the teaching of accounting, especially in courses judged to be of a practical nature. In addition, it was found that the role of the teacher is essential for the successful use of this methodology. However, the analysis of the syllabuses of the subjects taught by the interviewees showed that traditional teaching methods are still predominant. It was observed that the demotivation of students, lack of knowledge of teachers about the PBL method, as well as lack of interest and incentives to use a learning approach based on problems and institutional aspects are factors that hinder and constrain the use of this pedagogical intervention.

Study Contributions: The findings contribute to the discussion about the implementation of active methodologies in accounting education, specifically PBL, by identifying aspects that present themselves as challenges that need to be observed and overcome in their use.
Remote teaching in times of social distancing: a study in the accounting and actuarial sciences courses
Authors: Fernandes Maria Sueli Arnoud , Almeida Thiago Alexandre das Neves , Ribeiro Henrique Cesar Melo
Published: July 2022

Purpose: Considering the imposed social isolation measures to contain the spread of the Sars-Cov-2 virus, the cause of COVID-19 pandemic, the in-person classes started to be held remotely. Those measures had an impact on education, mainly because they had to be adopted quickly, with no time for preparation. In our current study, we investigate how remote teaching has been occurring in the undergraduate courses of Accounting and Actuarial Sciences at a Public Higher Education Institution (PHEI), in times of social distancing.

Methodology: An e-survey was carried out with teachers and students, in order to obtain information on the subject. The collected data were processed using statistical techniques to generate the results.

Results: It came across that the studied PHEI did not have resources such as a Flipped classroom, Digital Whiteboard or any other technological tools to support remote classes, since the remote teaching modality became a need during the COVID-19 pandemic. The PHEI launched, via public notices, programs for digital inclusion in order to acquire mobile data and equipment, such as computers/smartphones/tablets for students; however, only few of the students could have access to those resources.

Contributions of the Study: Our research results contribute to the state-of-the-art regarding undergraduate courses, by investigating their evolution towards remote learning. Such contributions provide information and knowledge on this subject to the national scientific literature, and give support and guidance to other courses offered by public and/or private higher education institutions.
Macronutrient dynamics in avocado (Persea americana Mill.) ‘Hass’ under the central peruvian coast conditions
Authors: Tomassini-Vidal Luis Rodrigo , Pino-Huasacca Nancy Marilu
Published: July 2022

The international growing demand of the avocado (Persea americana Mill.) market, together with the expansion of its agricultural area, requires the increasing of its technification, which makes necessary to have information aboutnutrient absorption in relation to its phenology. Therefore, an experiment was conducted in a commercial avocado production field of the farm “Don Ricardo” located on the central coast of Peru, in order to characterize the dynamics of macronutrients (N, P, K, Ca and Mg). The methodology followed and the results obtained will be the main guide to improve and implement more efficient fertilization strategies that will lead to higher yields and lower production costs in this crop. The experiment included 5 production cycles, from 2014-15 to 2018-19, in 7 phenological stages, collecting according to the crop development, leaves, panicles and fruits. 40 randomized plants were selected from a total of 50 plants marked as sampling area. The results were analyzed using a descriptive statistic, with box diagrams of the concentration of each nutrient by phenological stage. Two graphs per element were generated to represent the leaf dynamic and the fruit dynamic, respectively, including the data taken from the flower. It was concluded that the highest nutrient requirements of avocado were during the flowering, the fruit set and in fruits from 10 mm to 30 mm in diameter. The most abundant form of nitrogen was nitric, and it was accumulated mainly in the productive organs. The phosphorus, potassium, calcium and magnesium concentrations decreased as the fruit grew, and calcium and magnesium concentrations in leaves were higher than in fruits.
Epigallocatechin-3-gallate Induced HepG2 Cells Apoptosis through ROSmediated
AKT /JNK and p53 Signaling Pathway
Authors: Guan Yutao , Wu Qianlong , Li Miaomiao , Chen Danyang , Su Jingyao , Zuo Liandong , Zhu Bing , Li Yinghua
Published: July 2022

Background:

Hepatocarcinoma is the third leading cause of cancer-related deaths around
the world. Recently, some studies have reported that Epigallocatechin-3-gallate (EGCG) may have the
anti-cancer potential. However, the affection and putative mechanisms of cytotoxicity induced by
EGCG in HepG2 cells remain unknown. Based on the above, the present study evaluated the effect of
EGCG on the cytotoxic and anti-cancer mechanisms of HepG2 cells.

Methods:

The effect of EGCG on the apoptosis of Hep-G2 cells and its mechanism were studied by
cell counting kit-8, mitochondrial membrane potential assay with JC-1, Annexin V-FITC apoptosis
detection, cell cycle, and apoptosis analysis, one step TUNEL apoptosis assay, caspase 3 activity assay,
caspase 9 activity Assay, Reactive Oxygen Species assay, and Western blot.

Results:

EGCG-induced HepG2 cell apoptosis was confirmed by accumulation of the sub-G1 cells
population, translocation of phosphatidylserine, depletion of mitochondrial membrane potential, DNA
fragmentation, caspase-3 activation, caspase-9 activation, and poly (ADP-ribose) polymerase cleavage.
Furthermore, EGCG enhanced cytotoxic effects on HepG2 cells and triggered intracellular reactive
oxygen species; the signaling pathways of AKT, JNK, and p53 were activated to advance cell
apoptosis.

Conclusion:

The results reveal that EGCG may provide useful information on EGCG-induced HepG2
cell apoptosis and be an appropriate candidate for cancer chemotherapy.
Role of Terpenoids as Anticancer Compounds: An Insight into Prevention and Treatment
Authors: Chopra Bhawna , Dhingra Ashwani , Dhar Kanaya Lal
Published: July 2022

The human population is affected by the wide range of malignant cancers.
Several cancer treatment options, including surgery, radiation, chemotherapy,
immunotherapy, and others, are available or within our reach. However, the excessive
toxic effects that assimilate the negative impact on patients and thus impede progress in
cancer treatment have yet to be identified. Recent efforts in the research and
development of anticancer drugs derived from natural products have led to the
identification of numerous heterocyclic terpenes that inhibit cell proliferation,
metastasis, apoptosis, and other mechanisms. The anticancer activity of the terpenoids
is quite promising, and it could lead to more opportunities for cancer therapy. The
current chapter provides an overview of recent developments in the field of
heterocyclic terpenes and their analogues as anticancer compounds. As a result, this
provides an overview of the progress made in developing terpenes and analogues as
potential anticancer agents, including their synthetic modification, SAR, and action
mechanisms. The current studies are hoped to help researchers in increasing their
chances of gaining breakthrough insights in the field that can be used in cancer
therapeutic practise.
Recent Advances in Synthesis and the Anticancer Activity of Benzothiazole Hybrids as Anticancer Agents
Authors: Kumar Rajesh , Sharma Monika , Sharma Sarita , Singh Rajesh K.
Published: July 2022

Cancer is known as a silent killer that wreaks havoc on our immune systems. Cancer is the leading cause of death in the majority of cases. Resistance to anticancer drugs is becoming more agile, which encourages researchers to develop more effective cancer therapies. Heterocyclic compounds have long been important in advanced medicinal chemistry. Among the various heterocyclic scaffolds, benzothiazole (BT) is one of the most privileged moieties with a diverse range of biological activities such as anticancer, antidiabetic, anti-inflammatory, antiviral, antifungal, and so on. A large number of novel benzothiazole derivatives have been synthesized. Some of the mechanisms used by BT to treat cancer include tyrosine-kinase inhibitors, topoisomerase II inhibitors, CYP450 enzyme inhibitors, Abl kinase inhibitors, tubulin polymerase inhibitors, and HSP90 inhibitors. In this chapter, we will discuss various benzothiazole-hybrid compounds that optimise potency as well as anticancer activity in a concise manner. The goal of this chapter is to highlight recent research on benzothiazole scaffolds and their anticancer activity against various biological targets. The chapter will also provide updates on benzothiazole-containing drugs that are currently in clinical trials as well as those that have recently been granted patents.
Structure-Activity-Relationship (SAR) Studies of Novel Hybrid Quinoline and Quinolone Derivatives as Anticancer Agents
Authors: Panda Pravati , Chakroborty Subhendu , Unnamatla M.V. B.
Published: July 2022

Cancer, caused by uncontrolled cell growth in any part of the body, is a
significant life-threatening burden for the growing civilization. Though cancer research
has reached a high level, considering the high cost of the available therapies to treat
various cancers, the morbidity and mortality rates are still high. Organ toxicity, lack of
cell specificity, drug resistance, and short half-life with adverse side effects are the
major hurdles associated with currently used therapeutics. Therefore, there is a high
need to search for new anticancer agents with minimal side effects and toxicity. In this
connection, nature always acts as a treasury for scientists by offering its natural sources
to fight the war against various life-harvesting diseases. Nowadays, hybrid molecule
drug designs attract much attention among organic and medicinal chemists. What is
more interesting about the hybrid molecule is that, depending upon the target disease creating protein, scientists are designing and optimising the target molecule by
considering their structure-activity relationship studies (SARs). Among the different
natural sources, quinoline, quinolone, and their hybrid derivatives are the most
privileged ones. They are found as the central core of many bioactive natural products
as well as drug molecules (camptothecin, bosutinib, cabozantinib, pelitinib, lenvatinib,
levofloxacin, voreloxin, ciprofloxacin, garenofloxacin, etc.) acting as anticancer agents.
Literature is enriched with the excellent achievements of hybrid quinoline and
quinolone derivatives which function as anticancer agents through various mechanisms
such as Bcl-2 inhibition, ALDH inhibition, kinase inhibition, topo-II, and EGFR-TK
inhibition, etc. Given the excellent performance of quinoline and quinolone hybrid
derivatives, it will be worthwhile to continue researching them. 
Tetrazoles: Structure and Activity Relationship as Anticancer Agents
Authors: Unnamatla M.V. Basavanag , Nawaz Khan Fazlur-Rahman , Yañez Erick Cuevas
Published: July 2022

Heterocyclic compounds play an important role in drug design and
discovery, and they have been used to treat a variety of diseases, including cancer.
Cancer is one of the leading causes of death in the world. However, various drugs and
therapies are available on the market. The novel synthetic drugs show promising in vitro activity, but the route to clinical trials is hampered by their low bioavailability and
rapid metabolism. Tetrazoles have gained a lot of attention in recent years because they
have the broadest biological activity spectrum of any heterocycle. Tetrazoles are a type
of nitrogen heterocycle that has been found to be active in a variety of natural products
as well as the biologically active nucleus. A vast number of studies have demonstrated
the importance of this moiety in medicinal chemistry. The tetrazole ring has a similar
structure to carboxylic acids and functions as a bioisostere analogue. A bioisostere is a
group of molecules that have similar physiological properties, including biological
activity. Tetrazole derivatives have been shown to have anti-hypertension, anti-fungal,
anti-malarial, anti-leishmaniasis, anti-diabetic, anti-cancer, and a variety of other
biological activities. The tetrazole moiety functions as a good pharmacophore in the
drug design and discovery fields, particularly in terms of rational drug design with high
efficiency with structure and anti-cancer activity.
Progress in Nitrogen and Oxygen-based Heterocyclic Compounds for their Anticancer Activity: An Updates (2017-2020)
Authors: Choudhary Sakshi , Kumari Archana , Kumar Rajesh , Kumar Sahil , Singh Rajesh K.
Published: July 2022

Cancer, which is spreading throughout the world, is quickly becoming the
leading cause of major fatalities. The most difficult task for global researchers today is
to develop anticancer leads with minimal side effects. Heterocyclic chemistry is an
important and unique class of medicinal chemistry as a large number of drugs being
used in chemotherapy have a heterocyclic ring as their basic structure, in spite of
various side effects. Because of the presence of heteroatoms such as oxygen, nitrogen,
and sulphur, heterocyclic compounds can be used as hydrogen bond donors and
acceptors. As a result, they can more effectively bind to pharmacological targets and
receptors via intermolecular hydrogen bonds, resulting in pharmacological effects.
They can also change the liposolubility and thus the aqueous solubility of drug
molecules, resulting in remarkable pharmacotherapeutic properties. Medicinal chemists
are concentrating on anticancer agents based on heterocyclic compounds. The goal of
this chapter is to attempt to compile a dataset of advances in various nitrogen and
oxygen-containing heterocyclic rings with anticancer activities from 2017 to 2020. The
chapter covered the most recent research on novel anticancer heterocyclic derivatives,
as well as the structure-activity relationship (SAR). The chapter provides the reader
with advanced knowledge of the strategies required for designing nitrogen- and
oxygen-containing heterocyclic compounds as anticancer agents.
BIOLOGÍA DEL PICUDO DE LA YEMA DEL MANZANO AMPHIDEES LATIFRONS (SHARP) (COLEOPTERA: CURCULIONIDAE)
Authors: Guerrero Rodríguez Eugenio , Lezcano Barrozo José Ángel , Sánchez Valdez Víctor Manuel , Corrales Reynaga Jorge , Landeros Flores Jerónimo
Published: July 2022

Se determinó el ciclo biológico de Amphidees latifrons (Sharp), estimado en unidades calor (UC) y tomando como umbral de temperatura inferior 5EC. Se encontró que el ciclo biológico requiere un total de 4,564 UC (326 días), distribuidos como sigue: preoviposición 280 UC (20 días), incubación y eclosión 350 UC (25 días), desarrollo larval 1,260 UC (90 días), pupa 420 UC (30 días) y longevidad de adultos 2,254 UC (161 días). En el campo las poblaciones de L2, L3 y pupa se registraron de febrero a mayo; estas larvas se alimentan de raicillas secundarias de manzano. Los adultos estuvieron presentes todo el año, observándose poblaciones mayores en los meses de septiembre a noviembre, alimentándose durante este período de hojas, y de noviembre a febrero de yemas florales y vegetativas. El adulto es partenogenético, carece de alas voladoras y es de hábitos nocturnos.
Agreement between Measured and Self-reported Weight among Patients with Type 2 Diabetes through an mHealth Lifestyle Coaching Program in Denmark: A Validation Study (Preprint)
Authors: Imeraj Albi , Olesen Thomas Bastholm , Laursen Ditte Hjorth , Søndergaard Jens , Brandt Carl Joakim
Published: July 2022

BACKGROUND

Digital health interventions (DHIs) are increasingly used to handle and promote positive health behaviours. Clinical measures are often used, and a certain precision is essential for DHIs to have an effect. Few studies have compared clinically measured weight to self-reported weight. No study has examined the validity of self-reported weight from a mobile app used in a tailored weight loss intervention.

OBJECTIVE

To analyse the agreement between clinically measured versus self-reported weight collected from a mobile health (mHealth) lifestyle coaching program during a 12-month weight loss intervention for obese patients with and without type 2 diabetes (T2D). A secondary aim was to investigate determinants for possible discrepancies between clinically measured and self-reported weight by different demographic and lifestyle factors and achievement of weight loss goals.

METHODS

Weight registrations were collected from participants (n=104) from a Danish RCT examining the effect of digital lifestyle intervention on weight loss among obese patients with and without T2D. Data was collected at baseline and after 6 and 12 months. Self-reported weight was measured at home and registered into the app.

RESULTS

Self-reported body weight was lower compared to weight measured in the clinic; 1.03 kg, p<0.001 (1.01;1.05) after 6 months and 1.03 kg p<0.001 (0.99;1.04) after 12 months. Baseline weight and BMI after 6 months were associated with discrepancy between measured and self-reported weight with 0.03 kg, p=0.012 (0.01;0.04), and 0.09 kg p=0.017 (0.02;0.17), per increment of kg and kg/m2 respectively. Weight change during the first 6 months was also associated with difference between measured and self-reported weight with 0.1 kg, p=0.001, (0.04;0.01) per 1 kg of ∆weight. Non achievement of a 5% weight loss was associated with difference at 6 months with 0.79 kg (0.34;1.23). After 12 months only baseline weight was associated with discrepancy between measured and self-reported weight with 0.03 kg, p=0.019, 95% CI (0.01;0.05) per increment of kg. None of the other factors showed any significant discrepancy after 12 months.

CONCLUSIONS

Self-reported weight obtained from mHealth is a valid method for collecting anthropometric measurements.
Автосомно-рецесивна кінцівково-поясна м’язова дистрофія типу 2А: огляд літератури та клінічні спостереження
Authors: Kyrylova L.G. , Miroshnykov O.O. , Yuzva O.O. , Silaeva L.Yu. , Tkachuk L.I. , Beregela O.V. , Filozop M.V.
Published: July 2022

У статті наведено два клінічні випадки пацієнток з автосомно-рецесивною кінцівково-поясною м’язовою дистрофією типу 2А (LGMD2A). Дана форма м’язової дистрофії проявляється поступовою появою проксимальної м’язової слабкості у кінцівках та атрофічними змінами м’язів плечей, верхніх кінцівок і стегон. Обидві пацієнтки мали підвищений рівень креатинфосфокінази (КФК) та мутації c5050delA в гені CAPN3. Тип 2А — найпоширеніша форма кінцівково-поясної м’язової дистрофії, що становить близько 30% усіх випадків. LGMD2A викликається мутаціями гена, що кодує білок кальпаїн 3, і характеризується селективною атрофією та слабкістю м’язів проксимальних відділів кінцівок та м’язів верхнього і нижнього поясу. Вік появи м’язової слабкості надзвичайно мінливий: найчастіше від 8 до 15 років, хоча може коливатися в межах від 2 до 50 років. Запідозрити діагноз можна за результатами клінічного огляду та біопсії м’язів. Аналіз крові на рівень креатинкінази в сироватці крові зазвичай показує його підвищення, що свідчить про дистрофічний процес у м’язах. Діагноз повинен бути підтверджений шляхом виявлення мутації гена кальпаїну 3, що проводиться у зразку дезоксирибонуклеїнової кислоти в аналізі крові. На сьогодні не існує спеціальних методів лікування кінцівково-поясної м’язової дистрофії, проте ретельний менеджмент симптомів захворювання може поліпшити якість життя людини.
Роль генетичного секвенування у практиці дитячого невролога для діагностики рідкісних неврологічних захворювань, визначення прогнозу та таргетної терапії
Authors: Bocherova T.I. , Kubariev O.V. , Untilova Yu.O. , Holovashych Yu.O. , Buksha Ye.V.
Published: July 2022

Епілепсія може бути наслідком первинних генетичних аномалій або вторинною щодо чітко визначених структурних або метаболічних розладів, деякі з яких також мають генетичні причини. У клінічному випадку 1 дитині проведене генетичне секвенування (панель лейкодистрофій) та виявлено мутацію у гені GALC у гомозиготній формі, розташованому на 14-й хромосомі, що пов’язана з хворобою Краббе, яка успадковується за автосомно-рецесивним типом. На момент публікації статті дитині М. 1рік 6 міс., маса тіла 5800 г, захворювання неухильно прогресує. Амавроз, псевдобульбарні порушення (вигодовується через зонд). Спастичний тетрапарез. Часто хворіє на вірусно-бактеріальні інфекції, пневмонії. Клінічний випадок 2: дитина М., дівчинка віком 7 міс., надійшла в неврологічне відділення зі скаргами на частковий двобічний птоз, стридорозне дихання, втрату фізичних навичок. Проведене генетичне секвенування, виявлено мутацію в гені SCO2 у гомозиготній формі. Цей ген пов’язаний з автосомно-рецесивною кардіоміоенцефалопатією, спричиненою дефіцитом мітохондріального комплексу IV. Це автосомно-рецесивне тяжке мітохондріальне захворювання, при якому порушується енергетичний обмін у всіх життєво важливих органах (серце, легені, мозок). Ефективного методу лікування цього захворювання нині немає. Стан дитини прогресивно погіршувався. На жаль, у віці 9 місяців дитина померла від кардіореспіраторної недостатності. Клінічний випадок 3: хлопчик віком 1 рік 5 міс. надійшов до неврологічного стаціонару зі скаргами на часті серійні напади судом у вигляді синхронних, симетричних, раптових посмикувань верхнього плечового пояса (руки зігнуті в ліктьових суглобах, при кожному посмикуванні ступінчасто піднімаються вгору). Хлопчику було проведено генетичне обстеження: виявлено мутацію гена CACNA1H c.1912G>A (p.Gly638Ser), гетерозиготну форму. На основі даних генетичного обстеження проведена заміна вальпроату на топірамат. Після зміни терапії відзначались різко позитивні зміни у стані пацієнта та результатах ЕЕГ-дослідження.
DA LI CILj ZAISTA OPRAVDAVA SREDSTVO? PROBLEM MORALNOSTI I LEGITIMITETA U MAKIJAVELIJEVOJ POLITIČKOJ MISLI
Authors: Matic Ivan
Published: July 2022

Osnovni cilj ovog rada je temeljno razmatranje problema moralnosti i legitimiteta u okviru političke teorije renesansnog mislioca Nikola Makijavelija. U fokusu analize će biti centralni princip Makijavelijeve političke etike, koji opravdanost dela uslovljava njihovim krajnjim ishodom; tvrdićemo da, ukoliko je ispravno formulisan i protumačen, on može uspešno da služi kao kriterijum uspostavljanja legitimiteta političkih odluka. U prvom delu rada će biti okvirno predstavljen karakter Makijavelijeve političke misli, sa akcentom na smeštanje problema moralnosti i legitimiteta u teoriju koja im inače ne pridaje na značaju. Drugi deo će biti posvećen detaljnoj analizi ključne maksime Makijavelijeve političke etike, prema kojoj se legitimitet moralno problematičnih dela može braniti samo na osnovu njihovog pozitivnog ishoda, kao i njenoj popularnoj, pojednostavljenoj formulaciji „cilj opravdava sredstvoˮ. U trećem delu rada će biti ispitana i upoređena različita tumačenja koja Makijavelijevu političku misao u domenu etike opisuju kao amoralističku, odnosno kao imoralističku, nakon čega ćemo ponuditi originalnu interpretaciju koja političku etiku ovog renesansnog mislioca tumači kao jedinstven oblik moralizma.
"ТИБО-2022" − ЗНАЧИМОЕ ЦИФРОВОЕ СОБЫТИЕ ЕВРАЗИИ
Authors: Попов С.
Published: July 2022

XXVIII Международный форум по информационно-коммуникационным технологиям с выставкой "ТИБО-2022", организованный в Минске Министерством связи и информатизации Республики Беларусь при участии других государственных органов, стал не только главным отраслевым событием национального масштаба, но и уже традиционно площадкой
проведения ключевого "цифрового" мероприятия Евразийского экономического союза: IV Евразийского цифрового форума EADF-2022. В статье, в частности, представлена дорожная карта внедрения сетей 5G в Беларуси.
Effective Framework of Underwater Image Enhancement
Authors: Srivastava Anchal , Sadia Dr. Halima
Published: July 2022

Abstract: Underwater photographs are an excellent resource for learning about marine life and analysing the hydrothermal winds that blow across the seafloor. Low contrast, colour distortion, and poor visual appeal are the main obstacles that an underwater image faces. Light disperses and refracts as it progresses from rarer to denser, resulting in a plethora of complexities. The dispersion of light reduces the colour contrast. Water, in addition to dispersion, modifies subsea images due to the presence of subsea animals. We provide a new method for improving underwater fusion photos that accurately restores images underwater. Because the input and a set of processes, such as white balance, gamma correction, sharpening, and weight map manipulation, result in a single image. This research suggests a novel method for recovering and improving underwater photos. We recommended a light canal in front of the underwater environment as the initial step. A clear channel image was analysed and adjusted, environmental light was approximated, and the transmission image was refined in order to reconstruct underwater photos. The simulation was run using the MATLAB software.
Electricity Price Forecasting Using Artificial Neural Network
Authors: Gosaliya Jainam
Published: July 2022

Abstract: In strength markets there' s no regularity in forecasting of strength rate that is the most vital tasks & foundation for any selection making. In the aggressive strength markets forecasting of the strength rate is essential for purchasers and producers of strength for making plans their operations and additionally to keep the danger of strength. Forecasting additionally performs a very crucial function in financial optimization of strength utilization. Artificial intelligence (AI) alongside with the ELM-Tree Approach has been implemented in rate forecasting that is, the day in advance utilization of the strength and also will expect the month-to-month invoice of the person as in step with their utilization. For complexing the interdependencies among the strength charges, historic load utilization and numerous different factors synthetic neural networks are the excellent technique that can be used. This synthetic neural community technique is used to expect the behaviours of the marketplace primarily based totally on the different factors including historic charges, portions, and different data to forecast the destiny charges and load.
Design and Analysis of High Efficiency DC- DC Boost Converter for EV Charging Applications
Authors: Parthasarathy Dr. S.
Published: July 2022

Abstract: In today’s scenario DC-DC converters plays a major role in EV Charging. Normally, a boost converter would only be used when the output voltage minimum is about 1.5 times the input voltage. The main drawback in conventional converters is high ripple input current, which reduces the lifespan of the converter and overall system. Thus, conventional boost converters are not suitable for high voltage applications. To Overcome these Problems Modified SEPIC Converter is developed. This Modified SEPIC Converter is able to increase the Input voltage by 10 times. Modification of the Conventional SEPIC Converter is done by adding Capacitors and Diodes. This Paper also talks about the Design and analysis of the DC-DC Modified SEPIC Converter and controlling the Output voltage of the converter with a PI controller. The converter works at high efficiency and the Converter is operated at Continuous Conduction Mode (CCM). This Converter can effectively be applied for Photovoltaic Systems. The results of the Modified SEPIC converter for open loop and closed loop are simulated in MATLAB/SIMULINK.
Preventing Identity Theft using Blockchain Technology
Authors: Pathare Gaurav
Published: July 2022

Abstract: This paper's purpose is to describe what Blockchain Technology is and how it can be used to combat identity theft. Despite the fact that blockchain technology came to existence with Bitcoin, blockchain encompasses a comprehensive potential outside of cryptocurrency. Basically, blockchain could be a shared database that permits multiple parties to access information and verify that data in real-time It can transform the approach that we do things in various industries. It is used for a variety of things besides bitcoin, such as tracking ownership, digital assets, physical assets, and voting rights. It can store and run computer code known as smart contracts.
Multi-Functional Blind Stick for Visually Impaired People
Authors: M N Manasa
Published: July 2022

Abstract: Getting around, whether indoors or outdoors, is one of the most difficult tasks for the visually impaired. Furthermore, the poor state of the roads makes walking outside even more difficult for them.They must remain vigilant at all times to avoid dangerous situations such as colliding with stationary or moving obstacles, ascending or descending staircases, or slipping on damp terrain. They may also be distressed and wish to send an alarm message to their relatives or friends about their whereabouts. The issues that blind individuals face can be solved with the use of technology. To offer a medium between the blind and the environment, the suggested solution uses the Internet of Things (IoT) paradigm. Several sensors can be used Obstacles, staircases, and damp terrains are all examples of abnormalities that can be detected. The smart blind stick prototype presented here is a simple, intelligent, and cost-effective smart blind stick with a variety of IoT sensors and modules. Also included in this solution is the ability to send a message to those who are concerned about the user's whereabouts. In addition, a software programme is being developed to assist blind acquaintances in managing the stick's setup, such as adding or deleting phone numbers to which alarm messages must be sent. Indoors, misplacing the stick might be a serious problem. This solution also deals with the issue.
Design and Development of Light Motor Vehicle Exhaust System for Emission Control and Noise Reduction
Authors: Manjarikar Mr. Ajaykumar
Published: July 2022

Abstract: The ideal of this work is to develop a silencer that can amend dangerous exhaust discharge and noise produced in this conventional silencer. The health and hygienic policy depend upon the term air pollution. Weakened air causes physical illgoods and decides undesirable aesthetic and physiological goods. Air pollution can be defined as an inclusion to atmosphere of any material solid or gases which will have a various effect on life. The main adulterants contribute by machines are unburned hydrocarbon (UBHC), oxides of nitrogen (NOx), carbon monoxide (CO), and Lead. This research work is an attempt and contribution in this direction; it's substantially dealing with the comb of emission and noise. This system is fitted to the exhaust pipe of the machine. This type of silencer is used to reduce emission, and Noise and also reduces its dangerous goods with the help of actuated outland, lime water. As the Sound produced under lime water is less audible than it produced in the atmosphere. This is because of small sprockets which are present in water motes, which lower their breadth and lower the sound position. Hence water is used in this silencer. These silencers are used to reduce the noise and control the emissions of dangerous feasts and release much lower weakened feasts to the terrain and it's easy to install.
Centralized Framework to Send Notifications from Multiple Tools and Services on Multiple Messaging Platforms
Authors: Shet Nehal N
Published: July 2022

Abstract: One of the reasons for advancement in the field of technology and IT is that a lot of tech companies constantly innovate and come up with new ideas and products. Apart from the mainstream products and services, organizations also have a lot of tools and services to support the software development life cycle of their product. Different engineering teams would have different sets of tools and services that are used internally within an organization. Every patch of code goes through the phases of the software development life cycle which takes a considerable amount of time. Developers have to proactively monitor the status of the runs, jobs that validates their patch. This can block them and waste a lot of time. Notification is one of the means to inform users. Notifying developers at the right time can save their time, they can triage issues if any, or merge the code to production or take appropriate actions based on the status. With the growing number of tasks, runs and jobs being triggered, a notification feature will add value to the service users. But developing notification modules for all the services individually can be inefficient. A better solution would be to have a centralized notification framework that is capable of sending notifications from multiple services. This paper presents a generic notification framework that can be integrated with any kind of tools or services and will be able to send notifications on any messaging platform. The framework also addresses aspects like scalability, fault tolerance, reliability, maintenance and works in real-time
Using Neural Network Techniques to Detect Malicious URL for Preventing Ransomwares
Authors: Yadav Sonal
Published: July 2022

Abstract: Ransom ware is a kind of malignant malware programming that takes steps to distribute or hinders admittance to information or a PC framework, for the most part by scrambling it, until the casualty pays a payoff expense to the assailant. As a rule, the payoff request accompanies a cutoff time. Presently days and assailants executed new strategies for effective working of assault. The World Wide Web has become an important part of our everyday life for information communication and knowledge dissemination. Malicious URLs host unsolicited content (spam, phishing, drive-by exploits, etc.) and lure unsuspecting users to become victims of scams (monetary loss, theft of private information, and malware installation), and cause losses of billions of dollars every year. To detect such crimes systems should be fast and precise with the ability to detect new malicious content. The current work focuses on developing a model using convolutional neural networks for efficiently preventing ransom wares.