bluuebunny/crossref_metadata_2025 huggingface dataset:
The Heart of the Matter: A Unique Convergence of Cardiac Neoplasm, Hereditary Nonpolyposis Colorectal Cancer, and Spindle Cell Sarcoma
Authors: Bryer Emily , Hartner Lee
Published: December 2022

Primary cardiac tumours are exceedingly unusual and aggressive; they often develop in younger patients and present with advanced disease. The rarity and heterogeneity of primary cardiac tumours challenge the standardisation of therapeutic guidelines. Undifferentiated primary cardiac spindle cell sarcomas, a distinct subset of primary cardiac sarcomas, are especially unique with <20 cases reported worldwide, the majority of which are of left atrial origin. This article presents a review of the aetiology, pathophysiology, and therapy of undifferentiated primary cardiac spindle cell sarcomas. In conjunction, the authors present a unique case of a woman with hereditary nonpolyposis colorectal cancer (Lynch syndrome) who presented with a primary cardiac spindle cell sarcoma of left ventricular origin; this is the first case of this type and location of cardiac tumour reported in a patient with Lynch syndrome.
Mantle Cell Lymphoma: Are New Therapies Changing the Standard of Care?
Authors: Sharma Susmita , Sweetenham John W.
Published: December 2022

The prognosis of mantle cell lymphoma (MCL) has improved rapidly over recent years with the evolution of new management strategies. The disease, once considered fatal, has now become more of a chronic illness, with recurrent relapses that can be managed with a variety of treatment modalities, such as chemoimmunotherapy, stem cell transplantation, and novel targeted therapies. Several treatment options are already available for young, fit patients with newly diagnosed MCL, while many newer agents are being tested in relapsed/refractory MCL. The need for more effective treatment strategies in the elderly population is being addressed by numerous ongoing studies. With the advent of newer treatment modalities with more efficacy and less toxicity, it is now necessary to re-evaluate the way MCL is managed. This paper provides a comprehensive review of emerging, novel agents for the treatment of MCL.
Novel Targets and Therapies in T Cell Lymphoma
Authors: Kesavan Murali , Collins Graham P.
Published: December 2022

This review presents the recent advances in our understanding of the cellular pathogenesis of T cell non-Hodgkin lymphoma (NHL) and the potential of clinically targeted therapies. Patients with T cell NHL continue to face a limited prognosis, with the large majority experiencing a relapsed/refractory disease course and succumbing to their disease. Recent significant advances in our understanding of lymphomagenesis have not only revealed the complexity of T cell NHL but also helped to identify the cellular structures and pathways required for tumour proliferation, immune evasion, and therapy resistance. The NFκB pathway plays a critical role in T cell lymphoma through complex interactions with cell surface receptors and ligands, the proteasome, and crosstalk with ancillary pathways, such as the PI3K/Akt/mTOR cascade, which are also involved in chemokine and cytokine-mediated cellular signalling and growth. There is now also growing evidence for recurrent mutations involving the JAK/STAT pathway in a number of T cell lymphoma subtypes. Preclinical studies have highlighted the importance of novel cell surface proteins, downstream pathways, proteasome activation of NFκB, nuclear transport proteins, folate metabolism, epigenetic regulators, and cell of origin derivation. These advances represent a new era in T cell NHL therapy development. Although the optimal chemoimmunotherapy combination for first-line and salvage therapy is yet to be defined, the future paradigm is clearly shifting towards a biology-driven approach, which will hopefully yield improved outcomes for all patients with T cell lymphoma.
Genomic Profiling Clinical Trials in Cancer of Unknown Primary
Authors: Saul Helen
Published: December 2022

Cancer of unknown primary (CUP) accounts for 3–5% of all cancers,3,4 and prognosis is poor for most patients, with a median survival of 6–9 months.5 Clinical and pathological diagnostic work-up is required to determine whether patients belong to the favourable or unfavourable subset of CUP. Only 15–20% of patients belong to favourable subsets and have responses to therapy and outcomes similar to those of patients with the equivalent known metastatic primary tumour.4

For the patients in the unfavourable subsets (around 80–85% of CUP patients) treatment to date has been with chemotherapy. Median survival is <1 year5 and clinicopathological management of these patients is not expected to improve outcomes further. However, two different approaches involving genetic testing to guide patient management have the potential to offer progress.

The first approach is to use gene or methylation profiling tests to identify the tissue of origin. A number of tests are available that can be used to examine the gene expression or methylation signature of the CUP sample and assign a tissue of origin biologically. This approach is being used in clinical trials,6 but there is not yet solid clinical evidence that offering primary-specific therapy to these patients improves outcomes.

The second approach is to identify genomic aberrations that can be targeted therapeutically. Comprehensive genomic profiling (CGP) can identify aberrations that can be targeted with available agents in some patients,1 but there is no high-level evidence concluding that this approach improves outcomes. A novel molecularly guided trial, CUPISCO,7 was recently initiated and will address this issue in a Phase II, randomised, active-controlled, multicentre setting in patients with newly diagnosed, poor-prognosis CUP. The study aims to show the benefit associated with the use of genomic profiling to allocate molecularly targeted therapies or immunotherapies compared with the standard treatment of platinum-based chemotherapy in patients with CUP.
Strategi Pemasaran Digital Dalam Mempertahankan Bisnis Knalpot NDK Exhaust Masa Pandemi Covid-19
Authors: Rahmatul Hanifah Lutfia , Anisa Dewi Nur , Widiyawati Evi , Raharja Mahardhika Cipta
Published: December 2022

Industri digunakan sebagai suatu bagian produksi ekonomi yang terfokus pada proses manufakturisasi tertentu yang harus memiliki permodalan yang besar sebelum dapat meraih keuntungan. Negara indonesia merupakan salah satu basis otomotif terbesar di kawasan Asia Tenggara hingga saat ini. Produk otomotif yang ada di Indonesia salah satunya adalah knalpot racing. . Knalpot racing adalah salah satu bagian dari kendaraan atau alat yang dipasang dengan tujuan sebagai saluran akses pembuangan, biasanya terdapat pada kendaraan bermotor dan mobil. Pengrajin knalpot racing adalah seseorang yang membuat knalpot dari bahan mentah (belum jadi) menjadi barang siap pakai/ jual. Namun tidak dapat dipungkiri, semakin banyak pengrajin knalpot racing semakin besar pula persaingan dalam produksi.. Akibat pandemi covid-19 menyebabkan beberapa masalah terjadi di dunia industri knalpot racing. Namun permasalahan tidak berpengaruh pada pendapatan industri knalpot NDK Exhaust Purbalingga. Disaat para pengrajin knalpot mengeluh pendapatannya menurun akibat permasalahan di tengah pandemi covid-19, tetapi NDK Exhaust Purbalingga justru pendapatannya meningkat, bahkan mampu memasarkan produknya hingga ke luar negeri. Hal ini dikarenakan NDK Exhaust telah menerapkan sistem pemasaran 4 P yaitu produk (product), harga (price), tempat (place), dan promosi (promotion). Dan aktif melakukan promosi pada e-commerse.

 

Kata Kunci : e-commerce, ketahanan bisnis, strategi pemasaran
Analisa Reliability dan Availability Mesin Screw Press Kelapa
Authors: Yasir Sidqi , Saputra Arie
Published: December 2022

Kinerja dari sebuah mesin untuk proses produksi itu tergantung terhadap reliability dan availability mesin tersebut. Pada PT. Ujong Neubok Dalam (UND) adalah salah satu perusahaan yang memproduksi Crude Palm Oil (CPO) dan karnel. Target produksi di perusaaan adalah 270 ton/hari Tandan Buah Segar (TBS) yang akan diproduksi menjadi CPO.Permasalahn yang sering terjadi di PT. UND adalah terkait dengan kerusakan mesin (Down Time). Implikasinya menyebabkan proses produksi yang berlangsung menjadi tidak optimal. Penelitian ini bertujuan untuk menentukan tingkat availability dan realibility dari mesin screww press. Fokus kajian ditempatkan pada stasiun mesin screww press dikarenakan setelah observasi awal frekuensi downtime mesin sering terjadi pada mesin screw press. Kegagalan dari komponen mesin screw press dapat menghambat proses produksi  sehingga mengakibatkan tidak tercapainya target produksi yang telah ditetapkan oleh perusahaan. dalam penelitian ini telah melakukan analisa tingkat reliability dan availability dari mesin screw press kelapa sawit. Dari hasil perhitungan dapat kita lihat bahwa tingkat keandalan mesin screw press 2-3 memiliki tingkat keandalan 90 % dengan lama operasi 5 hari, dan untuk tingkat keandalan mesin screw press akan menurun terhadap bertambahnya waktu dan untuk ketersedian komponen selama kurun waktu 30 hari.
Efektivitas Limbah Kulit Bawang Putih Sebagai Pigmen Organik Dalam Pembuatan Tinta Spidol
Authors: Pratama Yudista Ade , Juhara Sutresna , Kurniasari Ratih
Published: December 2022

Limbah sisa kulit bawang putih berpotensi untuk dikembangkan menjadi produk yang memiliki nilai ekonomis tinggi, salah satunya sebagai bahan baku pigmen alternatif untuk pembuatan tinta spidol. Pembuatan tinta pigmen sendiri dapat dilakukan dengan penambahan gum arab sebagai bahan pengikat, etanol 96% sebagai pelarut, dan Polietilen glikol (PEG) sebagai pengendali adhesi. Penelitian ini bertujan untuk mengetahui apakah kulit bawang putih (Allium Sativum L) dapat digunakan sebagai  bahan baku utama pigmen tinta spidol yang ramah lingkungan. Penelitian dilakukan dengan variasi konsentrasi gum arab 1 gram, 1,5 gram, 2 gram, 2,5 gram, 3 gram, 3,5 gram dengan variasi waktu pengadukan 10 menit, 20 menit dan 30 menit. Hasil tinta yang mendekati tinta komersil adalah tinta dengan variasi gum arab sebanyak 1 gram dengan waktu pengadukan 10 menit dengan hasil massa jenis sebesar 1,114 gr/cm3, Viskositas sebesar 1,26 Poise, dan intensitas transmisi sebesar sebesar 0 lux. Dimana standar tinta komersil yang dihitung sebagai pembanding memiliki hasil massa jenis sebesar 1,026 gr/cm3, Viskositas sebesar 1,1 Poise, dan intensitas transmisi sebesar sebesar 0 lux.

 

Kata Kunci: Kulit Bawang Putih, Pigmen Organik, Tinta spidol.
Mediating Effect of Perceived Oral Health on the Relationship between Depression, Perceived Health, and Chewing Difficulty in Korean Adults: Using the 2020 Community Health Survey Data
Authors:   The Korean Society of Oral Health Science, Hong Min-Hee
Published: December 2022

Objectives: This study was conducted to examine the influence of perceived health and depression in Korean adults on chewing difficulty, using the 2020 community health survey data, and to verify the mediating effect of perceived oral health. Methods: An electronic survey was conducted by trained investigators between August 16 and October 31, 2020, among adults aged 19 years or older. The research tool investigated depression, perceived health, perceived oral health, and chewing difficulty. Results: 1. Depression (β = 0.20, p < 0.001) was found to have an effect on chewing difficulty, while perceived oral health (β = 0.54, p < 0.001) showed a partially mediating effect on the relationship between depression and chewing difficulty. 2. Perceived health (β = 0.19, p < 0.001) was found to have an effect on chewing difficulty. In the relationship between perceived health and chewing difficulty, perceived oral health (β = 0.54, p < 0.001) was shown to have a partial mediating effect. Conclusions: It is necessary to expand oral health policy to improve the masticatory function of adults and to expand oral health education to prevent the decrease in masticating function in advance.
Jual Beli Preset Lightroom melalui Media Sosial Perspektif Hukum Islam dan Undang Undang No. 8 Tahun 1999 tentang Perlindungan Konsumen
Authors: Maskuri Erkham , Arbaatun Luluk
Published: December 2022

Preset ligtroom merupakan kombinasi/kumpulan beberapa komposisi untuk editing foto didalam pengaturan lightroom untuk disimpan dan digunakan kembali. Namun tidak semua orang bisa menggunakan lightroom untuk mengedit foto, maka muncullah jual beli preset lightroom.Penelitian ini menggunakan metode kualitatif dengan jenis field research melalui pendekatan yuridis empiris yaitu menganalisis permasalahan dengan memadukan bahan hukum (data sekunder) dengan data primer.Hasil penelitian menunjukkan bahwa(1) praktik jual beli preset lightroom Seringkali membuat konsumen merasa dirugikan karena Isi dari paket preset seringkali berbeda dengan yang dicontohkan karena setelah diplay preset terbilang mirip dan tidak seistimewa yang dipromosikan.(2) Jual beli presetperspektif hukum Islam belum memenuhi rukun dan syarat jual beli karena terdapat ketidakjelasan dalam objek transaksi (gharar). Selama pembeli diberikan hak khiyar maka transaksi tersebut sah. Perlindungan konsumen dalam jual beli presetlightroom di media sosial telah memberikan hak konsumen kecuali pada ketentuan pasal 4 ayat (4), pasal 7 ayat (5), pasal 8 ayat (4)

Kata Kunci: Perlindungan Konsumen, Hukum Islam, Hukum Jual Beli
ONLINE TAXIBIKE (GRAB) CONTRIBUTION IN COMMUNITY SERVICE IN MALANG DISTRICT
Authors: Anam Moh Khoirul , Saifuddin Saifuddin , Fitriah Sulis Nada
Published: December 2022

Taxibike (grab) is a pick-up service with a modern, order-based Taxibike. Taxibike is a two-wheeled motor vehicle that is a very effective transportation.This application allows users who can order Taxibike online. Also known as a modern and professional Taxibike. The purpose of this study was to determine the contribution of online Taxibike in public services in Malang Regency. This research is a qualitative research with a qualitative description approach. The purpose of this research is to examine natural objects, to get an overview of the development of the transportation industry and the contribution of online Taxibike to public service in Indonesia, especially the Grab company. The results of this study indicate that the contribution of this online transportation application work system has a major impact on improving driver performance and is very beneficial for consumers and drivers of online transportation companies. Also this online Taxibike is a breakthrough in online business which is currently in demand by the Indonesian people, especially in the Malang district.
KONTRIBUSI GIRO DALAM PENGHIMPUNAN DANA CURRENT ACCOUNT SAVING ACCOUNT (CASA) PADA PT BANK SUMUT KCP SYARIAH SIMPANG KAYU BESAR
Authors: Subairi Subairi , Anwar Khoirul , Ramadhani Eka Fatma , Hamzah Muh.
Published: December 2022

This research is entitled “Kontribusi Giro Dalam penghimpunan Dana Current Account Saving Account (CASA) Pada PT Bank Sumut KCP Syariah Simpang Kayu Besar”. CASA is a source of low-cost banking funds collected from current account and saving account. with observation and interview methods. Current Account Saving Account (CASA) funds originating from low-cost funds, namely current account saving account at period 2019-2021. banking sector this certainly very influential on the condition of state income, especially at Therefore, this study also discusses the strategies taken by the company so that it is efficient in raising funds to maintain company.
MPLEMENTATION OF POS (point of sale) APPLICATIONS IN IMPROVING SERVICES AT KOPERSI INDUK PONDOK PESANTREN NURUL JADID PAITON PROBOLINGGO
Authors: Febrianto Achmad
Published: December 2022

The purpose of POS (point of sale) is to facilitate transactions through a sales-oriented activity and a system. For instance, in service, inventory management, and data on merchandise sales.The purpose of this study was to determine the extent to which the use of POS (point of sale) applications enhances consumer service. As a result of this study's findings, customers can now obtain services more easily through the use of POS (point of sale) applications.So that it can assist in the management of operational activities and improve the efficiency of service processes.With the transition from the manual to the digital mode of operation.It is beneficial for the chief cooperative officers in other service processes to ensure that this POS (point of sale) application can effectively simplify and speed up the service process when consumers are present.It is used to enhance consumer service during the transaction payment process.To enable officers of the central Pondok Pesantren cooperative to provide comprehensive service to students or customers, it is beneficial for the leading cooperative officers to be proficient in other service processes so that the application of this POS (point of sale) application can effectively simplify and speed up the service process in the presence of consumers.It is used to enhance consumer service during the transaction payment process. To enable officers of the leading Pondok Pesantren cooperative to provide complete service to students or customers, it is beneficial for officers of the leading cooperative to be proficient in other service processes so that the application of this POS (point of sale) application can simplify and accelerate the service process effectively when consumers are present. It is used in the transaction payment process to enhance consumer service, allowing the leading Pondok Pesantren cooperative officers to provide comprehensive service to students or customers.
El asilo en disputa: estrategias violentas de sujeción durante el gobierno de Donald Trump
Authors: Niño Vega Nohora Constanza
Published: December 2022

This paper identifies the Trump administration’s violent practices toward Central American and Mexican asylum-seeking families as a defensive response to the legal framework that grants them this protection tool in their relationship with the State. Through in-depth interviews and participant observation with migrant families in Tijuana during 2017-2020, it is concluded that the various measures implemented sought to limit asylum as a right and to configure an illegal subject based on suspicion, criminalization, and trauma. In this way, it was sought to reverse the character of legality that protects asylum seekers and rebuild a dominant vertical relationship of racialized subjection. The analysis seeks to contribute to migration studies by understanding the tension between the legality of asylum and the Trump administration’s actions to disrupt this framework.
MULTILETRAMENTOS NA EDUCAÇÃO SUPERIOR TECNOLÓGICA:
Authors: Almeida Luciana dos Santos , Da Silva Junior Carlos Alberto , Prados Rosália M N
Published: December 2022

Na educação superior tecnológica, as diferentes formas de linguagem e comunicação contribuem para o efetivo processo de ensino e aprendizagem para a formação do tecnólogo. Fundamenta-se teoricamente em estudos sobre a educação profissional, a educação superior tecnológica no Brasil e multiletramentos. Neste artigo, objetiva-se apresentar um levantamento bibliométrico e analítico da produção científica acadêmica, no que diz respeito ao tema multiletramentos e o ensino superior tecnológico, abrangendo o período de 2010 a 2021, com a intenção de identificar a pertinência e a relevância dos multiletramentos nas práticas de ensino do professor de educação superior tecnológica. Este estudo possibilita afirmar que o termo multiletramentos é relevante para as práticas docentes nesta área.
super-heróis como recursos de desenvolvimento humano em ambiente escolar
Authors: Weschenfelder Gelson Vanderlei , Mugge Ernani
Published: December 2022

As HQs de super-heróis, além de promover entretenimento, atuam sobre o leitor, pois apresentam questões que todo ser humano enfrenta no cotidiano. Suas temáticas estão relacionadas à superação de adversidades, à construção de identidade pessoal e de gênero, à ética, entre tantos outros.  Defende-se, neste estudo, sua inserção na escola, visto que elas se constituem em importante fonte de reflexão acerca da superação e do enfrentamento de situações difíceis. Para a realização do trabalho, contextualiza-se, preliminarmente, o contexto da juventude no Brasil e se discute, com base em autores diversos, a importância de intervenções positivas no âmbito escolar, no sentido de fortalecer o desenvolvimento do discente. Apresenta-se breve histórico das HQs e se discorre sobre como esse gênero pode atuar sobre o jovem ao fazê-lo se identificar com os personagens super-heróis. Por último, expõe-se, por meio de dois exemplos, como os super-heróis podem se constituir em referência para jovens.
Mitochondria inter-organelle relationships in cancer protein aggregation
Authors: Genovese Ilaria , Fornetti Ersilia , Ruocco Giancarlo
Published: December 2022

Mitochondria are physically associated with other organelles, such as ER and lysosomes, forming a complex network that is crucial for cell homeostasis regulation. Inter-organelle relationships are finely regulated by both tether systems, which maintain physical proximity, and by signaling cues that induce the exchange of molecular information to regulate metabolism, Ca2+ homeostasis, redox state, nutrient availability, and proteostasis. The coordinated action of the organelles is engaged in the cellular integrated stress response. In any case, pathological conditions alter functional communication and efficient rescue pathway activation, leading to cell distress exacerbation and eventually cell death. Among these detrimental signals, misfolded protein accumulation and aggregation cause major damage to the cells, since defects in protein clearance systems worsen cell toxicity. A cause for protein aggregation is often a defective mitochondrial redox balance, and the ER freshly translated misfolded proteins and/or a deficient lysosome-mediated clearance system. All these features aggravate mitochondrial damage and enhance proteotoxic stress. This review aims to gather the current knowledge about the complex liaison between mitochondria, ER, and lysosomes in facing proteotoxic stress and protein aggregation, highlighting both causes and consequences. Particularly, specific focus will be pointed to cancer, a pathology in which inter-organelle relations in protein aggregation have been poorly investigated.
Case report: Partial cystectomy for pheochromocytoma of the urinary bladder: A case report and review of literature
Authors: Hu Liang-Liang , Guo Zhong-Qiang , Dai Peng , Chen Gang , Tian Tao
Published: December 2022

Pheochromocytomas are neuroendocrine tumors that produce catecholamines and can be difficult to diagnose. Bladder involvement is uncommon with pheochromocytoma. Hypertension (sometimes with hypertensive crisis coinciding with micturition), headache, hematuria and syncope, which are commonly associated with voiding, are the most prevalent symptoms. While transurethral resection may be performed in roughly 20% of patients, 70% require partial cystectomy and 10% require radical cystectomy. We present a case of pheochromocytoma with hypertension and syncope that was often associated with voiding, satisfactorily treated by partial cystectomy.
Subclinical dysfunction of remote myocardium is related to high NT-proBNP and affects global contractility at follow-up, independently of infarct area
Authors: Diana Giovanni , Locorotondo Gabriella , Manfredonia Laura , Graziani Francesca , Lombardo Antonella , Lanza Gaetano Antonio , Pedicino Daniela , Liuzzo Giovanna , Massetti Massimo , Crea Filippo
Published: December 2022

Background

In ST-segment elevation myocardial infarction (STEMI), predictors of subclinical dysfunction of remote myocardium are unknown. We prospectively aimed at identifying clinical and biochemical correlates of remote subclinical dysfunction and its impact on left ventricular ejection fraction (LVEF).

Methods

One-hundred thirty-three patients (63.9 ± 12.1 years, 68% male) with first successfully treated (54% anterior, 46% non-anterior, p = 0.19) STEMI underwent echocardiography at 5 ± 2 days after onset and at 8 ± 2-month follow-up, and were compared to 13 age and sex-matched (63.3 ± 11.4) healthy controls. All 16 left ventricular (LV) segments were grouped into ischemic, border, and remote myocardium: mean value of longitudinal strain (LS) within grouped segments were expressed as iLS, bLS, rLS, respectively. LV end-diastolic (EDV), end-systolic (ESV) volumes indexed for body surface area (EDVi, ESVi, respectively), LVEF and global LS (GLS) were determined. Creatinine, glomerular filtration rate, admission level of NT-pro-brain-natriuretic peptide (NT-proBNP) and troponin peaks were considered for the analysis.

Results

At baseline, rLS (15.5 ± 4.4) was better than iLS (12.9 ± 4.8, p < 0.001), but lower than that in controls (19.1 ± 2.7, p < 0.001) and similar to bLS (15 ± 5.4, p = ns), and did not differ between patients with single or multivessel coronary artery disease (CAD). At multivariate regression analysis, only admission NT-proBNP levels but not peak Tn levels independently predicted rLS (β = −0.58, p = 0.001), as well as iLS (β = −0.52, p = 0.001). Both at baseline and at follow-up, rLS correlated to LVEF similarly to iLS and bLS (p < 0.001 for all). Median value of rLS at baseline was 15%: compared to patients with rLS ≥ 15% at baseline, patients with rLS < 15% showed lower LVEF (52.3 ± 9.4 vs. 58.6 ± 7.6, p < 0.001) and GLS (16.3 ± 3.9 vs. 19.9 ± 3.2), and higher EDVi (62.3 ± 19.9 vs. 54 ± 12, p = 0.009) and ESVi (30.6 ± 15.5 vs. 22.3 ± 7.6, p < 0.001) at follow-up.

Conclusion

In optimally treated STEMI, dysfunction of remote myocardium assessed by LS: (1) is predicted by elevated NT-proBNP; (2) could be independent of CAD extent and infarct size; (3) is associated to worse LV morphological and functional indexes at follow-up.
Tracing the source–sink process of fluvio-clastic materials: Magnetic records of surface sediments in the Yangtze River basin
Authors: Liu Xianbin , Chen Jing , Yue Wei , Wang Qing , Zhan Chao , Zeng Lin , Song Jian , Wang Longsheng , Cui Buli
Published: December 2022

In this study, we collected surface sediments from the mainstream and major tributaries of the Yangtze River to systematically analyse their magnetic properties, and discuss the implications for tracing source–sink process of fluvio-clastic materials. Our results showed that the surface sediments from tributaries in the upper basin had a significantly higher content of ferromagnetic minerals and coarser grain sizes than that in the mid-lower basin. The magnetic susceptibility (χlf) of surface sediments from the mainstream was 34.16*10-8 m3/kg at Shigu, rapidly rose to 230.56*10-8 m3/kg at Yibin, and then dropped to 68.92*10-8 m3/kg at the river mouth. The χlf of Yalong River sediments in the upper basin was 276.86*10-8m3/kg, considerably higher than that of the sediments from other tributaries, and greatly contribute to the χlf of the sediments in the mainstream, reflecting the dominant constraining role of the Emeishan basalts. The distinctive magnetic properties of the upper core sediments from Jianghan basin and the Yangtze delta closely match those of surficial river sediments of the upper Yangtze basin. This may indicate the addition of clastic materials eroded from the upper basin, resulting from the cut-through of the Three Gorges during the evolution of the Yangtze River that occurred in the late Cenozoic. Investigating the magnetic properties of the surface sediments in the Yangtze River basin can provide insights into the source–sink process of clastic materials and environmental changes.
The global role of Lrp in Vibrio alginolyticus and its response to diverse physicochemical factors
Authors: Su Wenxiao , Deng Yiqin , Zang Shujun , Gao Si’ao , Feng Juan
Published: December 2022

Leucine-responsive regulatory protein (Lrp) is an essential transcriptional regulator in prokaryotes. However, the regulatory role of lrp in Vibrio alginolyticus has still not been studied in detail. In this study, an lrp mutant strain was constructed to gain insight into the role of lrp in Vibrio alginolyticus. The absence of lrp significantly enhances swarming motility, biofilm formation, extracellular protease secretion activity, and tolerance to copper ions. The cumulative mortality of zebrafish (Danio rerio) challenged by intraperitoneal injection against the lrp mutant strain reached 68.89%, significantly higher than the 40.00% suffered by fish injected with the wild-type strain. The expression levels of lrp decreased gradually with increasing culture time under the influence of various physicochemical factors. The expression level of lrp was significantly increased after two hours of culture at pH 5, 22°C, 5% NaCl, the presence of 1 mM Cu2+, 1/4/7 mM ferric citrate, 0.1 mg/L NaNO3, and 0.1 mg/L KH2PO4. The mRNA level of lrp decreased significantly after six hours of culture at 37°C, 1% and 5% NaCl, and the presence of 1/7 mM ferric citrate, 0.1/5 mg/L NaNO3, and 0.1/0.5/2.0 mg/L KH2PO4. The expression of lrp increased after ten hours of culture at pH 5/9, 22°C, 1% NaCl, and the presence of 1 mM Cu2+, 7 mM ferric citrate, 5 mg/L NaNO3, and 0.1 mg/L KH2PO4. Overall, this study indicates that lrp negatively controls the virulence of V. alginolyticus, probably by reducing its swarming motility, biofilm formation, extracellular protease secretion activity, and tolerance to copper ions, and that the expression of lrp is affected by numerous physicochemical factors, and is especially up-regulated after 2 hours of culture in bacterial growth.
Microsecond-long simulation reveals the molecular mechanism for the dual inhibition of falcipain-2 and falcipain-3 by antimalarial lead compounds
Authors: Danazumi Ammar Usman , Balogun Emmanuel Oluwadare
Published: December 2022

The latest world malaria report revealed that human deaths caused by malaria are currently on the rise and presently stood at over 627,000 per year. In addition, more than 240 million people have the infection at any given time. These figures make malaria the topmost infectious disease and reiterate the need for continuous efforts for the development of novel chemotherapies. Malaria is an infectious disease caused majorly by the protozoan intracellular parasite Plasmodium falciparum and transmitted by mosquitoes. Reports abound on the central role of falcipains (cysteine protease enzymes) in the catabolism of hemoglobin for furnishing the plasmodium cells with amino acids that they require for development and survival in the hosts. Even though falcipains (FPs) have been validated as drug target molecules for the development of new antimalarial drugs, none of its inhibitory compounds have advanced beyond the early discovery stage. Therefore, there are renewed efforts to expand the collection of falcipain inhibitors. As a result, an interesting finding reported the discovery of a quinolinyl oxamide derivative (QOD) and an indole carboxamide derivative (ICD), with each compound demonstrating good potencies against the two essential FP subtypes 2 (FP-2) and 3 (FP-3). In this study, we utilized microsecond-scale molecular dynamics simulation computational method to investigate the interactions between FP-2 and FP-3 with the quinolinyl oxamide derivative and indole carboxamide derivative. The results revealed that quinolinyl oxamide derivative and indole carboxamide derivative bound tightly at the active site of both enzymes. Interestingly, despite belonging to different chemical scaffolds, they are coordinated by almost identical amino acid residues via extensive hydrogen bond interactions in both FP-2 and FP-3. Our report provided molecular insights into the interactions between FP-2 and FP-3 with quinolinyl oxamide derivative and indole carboxamide derivative, which we hope will pave the way towards the design of more potent and druglike inhibitors of these enzymes and will pave the way for their development to new antimalarial drugs.
Case report: Alexander's disease with “head drop” as the main symptom and literature review
Authors: Yuan Yujun , Wu Qiong , Huo Liang , Wang Hua , Liu Xueyan
Published: December 2022

Alexander's disease (AxD) is a rare autosomal dominant hereditary disorder that is caused by the mutations in the GFAP gene, which encodes the glial fibrillary acidic protein (GFAP). This neurogenerative disease has many clinical manifestations, and the onset of disease spans a wide range of ages, from newborns to children, adults, and even the elderly. An overaccumulation of the expression of GFAP has a close causal relationship with the pathogenesis of Alexander's disease. Usually, the disease has severe morbidity and high mortality, and can be divided into three distinct subgroups that are based on the age of clinical presentation: infantile (0–2 years), juvenile (2–13 years), and adult (>13 years). Children often present with epilepsy, macrocephaly, and psychomotor retardation, while adolescents and adults mainly present with muscle weakness, spasticity, and bulbar symptoms. Atonic seizures are a type of epilepsy that often appears in the Lennox–Gastaut syndrome and myoclonic–astatic epilepsy in early childhood; however, the prognosis is often poor. Atonic episodes are characterized by a sudden or frequent reduction in muscle tone that can be local (such as head, neck, or limb) or generalized. Here, we report a 4-year-old girl whose main symptoms were intermittent head drop movements, which could break the frontal frame and even bleed in severe conditions. A video-encephalography (VEEG) showed that the nodding movements were atonic seizures. A head magnetic resonance imaging (MRI) revealed abnormal signals in the bilateral paraventricular and bilateral subfrontal cortex. The gene detection analyses indicated that the GFAP gene exon 1 c.262 C>T was caused by a heterozygous mutation, as both her parents were of the wild-type. The girl had no other abnormal manifestations except atonic seizures. She could communicate normally and go to kindergarten. After an oral administration of sodium valproate, there were no atonic attacks. Although epilepsy is a common symptom of Alexander's disease, atonic seizures have not been reported to date. Therefore, we report a case of Alexander's disease with atonic seizures as the main symptom and provide a review of the literature.
A hybrid unsupervised and supervised learning approach for postictal generalized EEG suppression detection
Authors: Li Xiaojin , Huang Yan , Lhatoo Samden D. , Tao Shiqiang , Vilella Bertran Laura , Zhang Guo-Qiang , Cui Licong
Published: December 2022

Sudden unexpected death of epilepsy (SUDEP) is a catastrophic and fatal complication of epilepsy and is the primary cause of mortality in those who have uncontrolled seizures. While several multifactorial processes have been implicated including cardiac, respiratory, autonomic dysfunction leading to arrhythmia, hypoxia, and cessation of cerebral and brainstem function, the mechanisms underlying SUDEP are not completely understood. Postictal generalized electroencephalogram (EEG) suppression (PGES) is a potential risk marker for SUDEP, as studies have shown that prolonged PGES was significantly associated with a higher risk of SUDEP. Automated PGES detection techniques have been developed to efficiently obtain PGES durations for SUDEP risk assessment. However, real-world data recorded in epilepsy monitoring units (EMUs) may contain high-amplitude signals due to physiological artifacts, such as breathing, muscle, and movement artifacts, making it difficult to determine the end of PGES. In this paper, we present a hybrid approach that combines the benefits of unsupervised and supervised learning for PGES detection using multi-channel EEG recordings. A K-means clustering model is leveraged to group EEG recordings with similar artifact features. We introduce a new learning strategy for training a set of random forest (RF) models based on clustering results to improve PGES detection performance. Our approach achieved a 5-second tolerance-based detection accuracy of 64.92%, a 10-second tolerance-based detection accuracy of 79.85%, and an average predicted time distance of 8.26 seconds with 286 EEG recordings using leave-one-out (LOO) cross-validation. The results demonstrated that our hybrid approach provided better performance compared to other existing approaches.
Sensory function in the faces of patients with facial palsy: A prospective observational study using quantitative sensory testing
Authors: Volk Gerd Fabian , Döhler Marianna , Klinger Carsten M. , Weiss Thomas , Guntinas-Lichius Orlando
Published: December 2022

Objectives/Hypothesis

To determine the sensory function of both sides of the face in patients with acute or chronic facial palsy.

Study design

Prospective observational study.

Methods

The standardized quantitative sensory testing (QST) protocol of the German Research Network on Neuropathic Pain (DFNS), including thermal or mechanical stimuli (touch, pain, vibration, and pressure), was used to investigate somatosensory function in the faces of patients. A patient-reported outcome measures for the assessment of disturbed facial comfort or facial pain, the facial Clinimetric Evaluation Scale (FaCE) Facial Comfort Subscale, and the 36-Item Short Form Survey (SF-36) pain subdomain were used.

Results

A total of 29 patients (22 female, median age of 48 years; 7 acute palsy; 22 chronic palsy; House-Brackmann grade II–VI) were included. The median FaCE Facial Comfort Subscale score and the median SF-36 pain subdomain score were 50 and 100, respectively. Most patients had, at an individual level, a normal sensory function in all or most tests. On average, the frequencies for all parameters were not different between the paretic side and the contralateral side (all p > 0.05). Additionally, when z-scores were used to compare our patient sample with healthy controls from the DFNS reference database, there was no difference between the paretic side and the contralateral side (all p > 0.05). Furthermore, there were no differences between patients with acute facial palsy and those with chronic facial palsy (all p > 0.05). The FaCE Facial Comfort Subscale score and the SF-36 pain subdomain score did not correlate with the QST parameters (all p > 0.05).

Conclusion

Patients with acute or chronic unilateral peripheral facial palsy had normal sensory function on the paretic and contralateral sides compared with the reference values of healthy controls, and there was no significant difference between the sides. The numbness frequently felt in the affected hemiface is not related to a peripheral sensory disorder and is most likely a manifestation of an unsolved cortical somatosensory-motor mismatch.
Correlation between adenoma detection rate and other quality indicators, and its variability depending on factors such as sedation or indication for colonoscopy
Authors: Groza Andrei Lucian , Ungureanu Bogdan Silviu , Tefas Cristian , Miuțescu Bogdan , Tanțău Marcel
Published: December 2022

Colorectal cancer (CRC) is an important worldwide public health burden and colonoscopy is the main diagnostic and most importantly, preventive method. For this reason, many countries have implemented national or regional CRC screening programs. High-quality colonoscopy is a prerequisite to effectively detect premalignant lesions, like adenomas. The quality of colonoscopy is assessed using several quality indicators, the main one being adenoma detection rate (ADR). In Romania, despite CRC having the highest incidence of all cancers, there is no national screening program and quality in colonoscopy is not routinely assessed. We therefore wanted to evaluate the actual level of quality in colonoscopy in a region of Romania. Our study was conducted in two private endoscopy clinics over a period of 7 months. 1,440 consecutive colonoscopies performed by five physicians were included in the study. We found that the quality level is above the minimum one recommended by international societies and that the ADR calculation method does not significantly influence its value. Furthermore, ADR correlated well with other quality indicators such as polyp detection rate (PDR) and adenoma per colonoscopy (APC). An interesting finding was that ADR was higher among colonoscopies performed without sedation. Thus, our data encourage endoscopists to adopt a sedation-free colonoscopy in their practice without an impact on the quality of the procedure.
The contextual cogs of “migrant jobs”: A comparative study of the institutional determinants of migrant marginalization in European labor markets
Authors: King Seán
Published: December 2022

Migrants play a significant role in European labor markets and are used as sources of “cheap labor”; often being disproportionately represented in low-wage, poor conditions, or otherwise precarious positions. Past research has suggested that the process of migrants being filtered into these low-end occupations is linked to institutional factors in receiving countries such as immigration policy, the welfare state and employment regulation. This paper calculates the extent of migrant marginalization in 17 European countries and uses qualitative comparative analysis (QCA) and regression modeling to understand how institutional factors operate and interact, leading to migrant marginalization. The QCA showed that when a country with a prominent low skills sector and restrictive immigration policy is combined with either strong employment protection legislation or a developed welfare state, migrants will be more strongly marginalized on the labor market. The results of the statistical analysis largely aligned with the idea that restrictive immigrant policy by itself and in combination with other factors can increase marginalization.
Perceptional differences in the factors of local acceptance of waste incineration plant
Authors: Huang Yangsen , Zhang Ziqi , Zhang Yanbo , Wang Zixing
Published: December 2022

Existing research has documented that public attitudes towards waste incineration plants are determined by various factors, such as risk perception, economic impacts, and social trust. However, the diversity in perceptions within communities hosting waste incineration plants is understudied. Adds to existing knowledge, the present paper employed the Q methodology to examine the perceptions of residents living in the vicinity of a waste incineration plant in Xuzhou, China. The results revealed four perspectives on residents’ perceptions towards waste incineration plants: I do not trust them and feel besieged by risks; I trust local governments but I am unfairly treated; I attach this place a lot but I am unfairly treated; I possess knowledge of waste incineration and feel besieged by risks. Our data show that risk perception, trust perception, and political efficacy perception are underlying reasons for local acceptance of waste incineration plants. The diversified subjectivities we obtained supplement existing literature that quantitatively documents the influencing factors. These findings demonstrate that it is necessary to explicitly consider the deep-seated values and perspectives among hosting residents’ for the siting of the waste incineration plant.
Do mothers treat children who are similar to them better? The relation between maternal–adolescent neuroticism congruence and a punitive parenting style
Authors: Peng Shun , Xu Lei , Chen Jiwen , Cai Shuangshuang
Published: December 2022

Parenting style is the relatively stable behaviors parents display during the childrearing process. It is an important factor in children’s socialization and the mother–child relationship. The present study aimed to test the relationship between maternal–adolescent neuroticism congruence and a punitive parenting style. A total of 882 Chinese adolescents and their mothers participated in this study. The results showed that maternal–adolescent high-neuroticism congruence was associated with a more punitive parenting style than low-neuroticism congruence. The more incongruent the maternal–adolescent neuroticism was, the less punitive the parenting style. There were moderating effects of adolescent gender on maternal–adolescent neuroticism congruence/incongruence and punitive parenting style. These findings provide a new perspective for exploring the relationship between parent–child interaction and parenting styles.
Does the trained immune system play an important role in the extreme longevity that is seen in the Sardinian blue zone?
Authors: Soloski Mark J. , Poulain Michel , Pes Giovanni M.
Published: December 2022

Villages in the island of Sardinia in the Mediterranean that display exceptional longevity are clustered within a defined mountainous region. Because of their unique location we hypothesize that these villages had a unique infectious disease exposure relevant to the observed successful longevity. These highland villages had a significant exposure to malaria in the first half of the 20th century after which malaria was eliminated due to vector control mechanisms. In addition, there is likely a high incidence of Helicobacter pylori infections among shepherds in Sardinia, the primary occupation of many living in the LBZ, as well as helminth infections among children. This suggests that individuals living in the LBZ had a unique infectious disease exposure. Specifically, we hypothesize that the continued high exposure of residents in the LBZ to these infectious agents prior to the 1950s lead to the generation of a uniquely trained (or imprinted) immune system. Once some of these diseases were eliminated in the latter half of the century, individuals within the LBZ were equipped with a trained immune system that was uniquely capable of not only responding effectively to common infections but also responding in a manner that maximized maintaining tissue health. In addition, there are lifestyle factors that also favor such a trained immune system. This hypothesis may help explain the slow progression of chronic immune mediated diseases as well as other chronic non-transmissible age-related diseases seen in the Sardinian LBZ and serve as a template for future studies that support or refute this hypothesis.
Decay of oil residues in the soil is enhanced by the presence of Spartina alterniflora, with no additional effect from microbiome manipulation
Authors: Formel Stephen K. , Martin Allyson M. , Pardue John H. , Elango Vijaikrishnah , Johnson Kristina , Gunsch Claudia K. , Lefèvre Emilie , Varner Paige M. , Kim Yeon Ji , Bernik Brittany M. , Van Bael Sunshine A.
Published: December 2022

Recent work has suggested that the phytoremediation potential of S. alterniflora may be linked to a selection by the plant for oil-degrading microbial communities in the soil, in combination with enhanced delivery of oxygen and plant enzymes to the soil. In salt marshes, where the soil is saline and hypoxic, this relationship may be enhanced as plants in extreme environments have been found to be especially dependent on their microbiome for resilience to stress and to respond to toxins in the soil. Optimizing methods for restoration of oiled salt marshes would be especially meaningful in the Gulf of Mexico, where there is a persistently high threat of petroleum contamination. One favorable strategy for restoration of oiled sites might include planting S. alterniflora with a microbiome that has been pre-selected for an oiled environment. We examined this strategy with a two-year greenhouse experiment and found that planting S. alterniflora in an oiled environment enhances decomposition of oil residues without a clear negative impact on plant growth. Manipulation of the S. alterniflora microbiome through soil inoculation and through exposure to oil residues, elicited a detectable response of soil prokaryote communities to the presence of oil, while only demonstrating an analogous response in fungal communities in the plant roots and leaves. Yet, manipulation of the plant microbiome did not change plant morphology or relative decomposition of polycyclic aromatic hydrocarbons (PAHs) in the soil. Therefore, despite evident relationships between the plant, microbes, and oil, manipulation of the microbiome may not be a worthwhile addition to S. alterniflora phytoremediation strategies. Nevertheless, our work adds support for replanting S. alterniflora in oiled salt marshes as an effective strategy for reducing oil residues in salt marshes, in addition to the re-vegetation and erosion reduction benefits demonstrated by others.