bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparing the Volatile and Soluble Profiles of Fermented and Integrated Chinese Bayberry Wine with HS-SPME GC–MS and UHPLC Q-TOF
Authors: Miao Yingjie , Hu Gaowei , Sun Xiaolong , Li Yashi , Huang Huanting , Fu Yongqian
Published: April 2023

To evaluate the flavor characteristics of Chinese bayberry alcoholic beverages, fermented bayberry wine (FBW) and integrated bayberry wine (IBW) were investigated for their volatile and soluble profiles using HS-SPME GC–MS and UHPLC Q-TOF and were analyzed with multidimensional statistical analysis, including PCA and OPLS-DA. The volatile compounds 1-pentanol, β-caryophyllene and isopentanol were only detected in IBW. β-caryophyllene, the key flavor component of bayberry, was found to be the most abundant volatile compound in IBW (25.89%) and was 3.73 times more abundant in IBW than in FBW. The levels of ethyl octanoate, ethyl nonanoate, and ethyl decanoate were also several times higher in IBW than in FBW. These compounds contributed to the strong bayberry aroma and better fruity flavor of IBW. On the other hand, high levels of ethyl acetate and octanoic acid in FBW, representing pineapple/overripe or sweat odor, were key contributors to the fermented flavor of FBW. Soluble sugars, such as sucrose, D-glucose, and D-tagatose, as well as amino acids, such as L-glutamate and L-aspartate, had much higher levels in IBW. The anthocyanin pigment cyanidin 3-glucoside, which generates red color, was also higher in IBW. On the other hand, most of the differentially expressed alcohols, acids, amino acids, purines/pyrimidines and esters were present in higher concentrations in FBW compared to IBW. This demonstrated that IBW has a much sweeter and more savory taste as well as a better color generated by more anthocyanins, while FBW presents a more acidic and drier taste as well as a complex formation of alcohols and esters. The study also prompts the need for further research on the flavor profiles of IBW and its potential application and market value.
From Waste to Taste: Application of Fermented Spent Rootlet Ingredients in a Bread System
Authors: Neylon Emma , Nyhan Laura , Zannini Emanuele , Sahin Aylin W. , Arendt Elke K.
Published: April 2023

The process of upcycling and incorporating food by-products into food systems as functional ingredients has become a central focus of research. Barley rootlets (BR) are a by-product of the malting and brewing industries that can be valorised using lactic acid bacteria fermentation. This research investigates the effects of the inclusion of unfermented (BR-UnF), heat-sterilised (BR-Ster), and five fermented BR ingredients (using Weissella cibaria MG1 (BR-MG1), Leuconostoc citreum TR116 (BR-TR116), Lactiplantibacillus plantarum FST1.7 (BR-FST1.7), Lactobacillus amylovorus FST2.11 (BR-FST2.11), and Limosilactobacillus reuteri R29 (BR-R29) in bread. The antifungal compounds in BR ingredients and the impact of BR on dough rheology, gluten development, and dough mixing properties were analysed. Additionally, their effects on the techno-functional characteristics, in vitro starch digestibility, and sensory quality of bread were determined. BR-UnF showed dough viscoelastic properties and bread quality comparable to the baker’s flour (BF). BR-MG1 inclusion ameliorated bread specific volume and reduced crumb hardness. Breads containing BR-TR116 had comparable bread quality to BF, while the inclusion of BR-R29 substantially slowed microbial spoilage. Formulations containing BR-FST2.11 and BR-FST1.7 significantly reduced the amounts of sugar released from breads during a simulated digestion and resulted in a sourdough-like flavour profile. This study highlights how BR fermentation can be tailored to achieve desired bread characteristics.
Silver Carp (Hypophthalmichthys molitrix) Scales Collagen Peptides (SCPs): Preparation, Whitening Activity Screening and Characterization
Authors: Zu Xiao-Yan , Li Mei-Jin , Xiong Guang-Quan , Cai Jun , Liao Tao , Li Hai-Lan
Published: April 2023

This study involves the preparation of scale collagen peptides (SCPs) with whitening activity from silver carp (Hypophthalmichthys molitrix) and their characterization and peptide sequence identification. In this article, scanning electron microscopy (SEM) was used to observe structure changes of sliver carp scales; enzymatic hydrolysis was optimized through protease screening and response surface optimization. The ultrafiltration was used to separate SCPs and the whitening activity was comprehensively evaluated using radical scavenging rate and tyrosinase-inhibiting activity, among others. An optimal component was characterized and identified using various modern spectral analysis techniques. The results showed that the surface of silver carp scales after decalcification was smooth and clear. The pepsin had the highest peptide yield and tyrosinase-inhibiting activity (90.01% and 82.25%, respectively). The optimal enzymatic hydrolysis conditions were an enzyme dosage of 16.1%, a solid–liquid ratio of 1:15.6 and a time of 4.9 h. The proportions of hydrophobic and basic amino acids in the peptide composition were 32.15% and 13.12%, respectively. Compared with SCPs2, SCPs1 (6096.68–9513.70 Da) showed better ·OH scavenging ability, tyrosinase-inhibiting activity and moisture absorption. SCPs1 was a macromolecular fragment of type I collagen with a triple helix structure, containing three peptide sequences with the potential for tyrosinase activity inhibition (AGPPGADGQTGQRGE, SGPAGIAGPAGPRGPAGPNGPPGKD and KRGSTGEQGSTGPLGMRGPRGAA). These results show that SCPs1 is a collagen peptide product with whitening potential.
Consumer Attitude towards Genetically Modified Foods in Iran: Application of Three-Dimensional Model of Corporate Social Responsibility
Authors: Akbari Morteza , Fozouni Ardekani Zahra , Pino Giovanni , Valizadeh Naser , Karbasioun Mostafa , Padash Hamid
Published: April 2023

Although GM food production is considered an important strategy to meet the growing food needs of the population around the world, a majority of the GM food consumers express doubts about purchasing and eating them. However, it can be argued that consumers have different opinions about GM foods and their influence on human health and the natural environment. GM food producer Corporate Social Responsibility (CSR) may significantly affect such opinions, but the effect of this variable has been partially neglected in previous research studies. To address this gap, the present study investigates Iranian consumers’ concerns about GM foods, trust in these products, and perception of GM food producer CSR as determinants of attitudes towards GM food. Data were collected from Iranian consumers. A cross-sectional survey research with a multi-stage random sampling approach was employed to capture the responses of 372 Iranian consumers. The results showed that consumers have both negative and positive attitudes towards GM foods. Perceived social equity, trust, and health concerns were the most important determinants of attitude towards GM foods. According to the results, these variables could account for 52.9% (Cox and Snell R2) and up to 70.6% (Nagelkerke R2) of the variance of the dependent variable. Furthermore, results revealed statistically significant differences among the consumers with different educational levels in terms of perceived social equity, perceived environmental responsibility, and environmental concern. The research contributes to the body of knowledge in GM food consumption by evolving the CSR to assess attitudes of users concerning GM foods.
Purification and Characterization of the Enzyme Fucoidanase from Cobetia amphilecti Utilizing Fucoidan from Undaria pinnatifida
Authors: Liu Shu , Wang Qiukuan , Shao Zhenwen , Liu Qi , He Yunhai , Ren Dandan , Yang Hong , Li Xiang
Published: April 2023

Fucoidanase is an unstable enzyme with high specificity that requires a large about of time to screen it from microorganisms. In this study, enzymatic hydrolysis was used to produce low-molecular-weight fucoidan from microorganisms via the degradation of high-molecular-weight fucoidan without damage to the sulfate esterification structure of oligosaccharide. The microbial strain HN-25 was isolated from sea mud and was made to undergo mutagenicity under ultraviolet light. Fucoidanase was extracted via ultrasonication and its enzymatic activity was improved via optimization of the ultrasonic conditions. The enzymatic properties and degradation efficiency of fucoidanase were characterized. The microbial strain HN-25 is a Gram-negative aerobic and rod-shaped-cell bacterium, and therefore was identified as Cobetia amphilecti via 16s rDNA. The results proved that fucoidanase is a hydrolytic enzyme with a molecular weight of 35 kDa and with high activity and stability at 30 °C and pH 8.0. The activity of fucoidanase was significantly enhanced by sodium and calcium ions and inhibited by a copper ion and ethylenediaminetetraacetate (EDTA). There was a significant decrease in the molecular weight of fucoidan after enzymatic hydrolysis. The low-molecular-weight fuicodan was divided into four fractions, mainly concentrated at F3 (20~10 kDa) and F4 (≤6 kDa). These consequences suggest that fucoidanase obtained from Cobetia amphilecti is stable and efficient and could be a good tool in the production of bioactive compounds.
Controllability of a Class of Heterogeneous Networked Systems
Authors: Ajayakumar Abhijith , George Raju K.
Published: April 2023

This paper examines the controllability of a class of heterogeneous networked systems where the nodes are linear time-invariant systems (LTI), and the network topology is triangularizable. The literature contains necessary and sufficient conditions for the controllability of such systems where the control input matrices are identical in each node. Here, we extend this result to a class of heterogeneous systems where the control input matrices are distinct in each node. Additionally, we discuss the controllability of a more general system with triangular network topology and obtain necessary and sufficient conditions for controllability. Theoretical results are supplemented with numerical examples.
Multistability and Jump in the Harmonically Excited SD Oscillator
Authors: Wang Zhenhua , Shang Huilin
Published: April 2023

Coexisting attractors and the consequent jump in a harmonically excited smooth and discontinuous (SD) oscillator with double potential wells are studied in detail herein. The intra-well periodic solutions in the vicinity of the nontrivial equilibria and the inter-well periodic solutions are generated theoretically. Then, their stability and conditions for local bifurcation are discussed. Furthermore, the point mapping method is utilized to depict the fractal basins of attraction of the attractors intuitively. Complex hidden attractors, such as period-3 responses and chaos, are found. It follows that jumps among multiple attractors can be easily triggered by an increase in the excitation level or a small disturbance of the initial condition. The results offer an opportunity for a more comprehensive understanding and better utilization of the multistability characteristics of the SD oscillator.
A Seventh Order Family of Jarratt Type Iterative Method for Electrical Power Systems
Authors: Yaseen Saima , Zafar Fiza , Chicharro Francisco I.
Published: April 2023

A load flow study referred to as a power flow study is a numerical analysis of the electricity that flows through any electrical power system. For instance, if a transmission line needs to be taken out of service for maintenance, load flow studies allow us to assess whether the remaining line can carry the load without exceeding its rated capacity. So, we need to understand about the voltage level and voltage phase angle on each bus under steady-state conditions to keep the bus voltage within a specific range. In this paper, our goal is to present a higher order efficient iterative method to carry out a power flow study to determine the voltages (magnitude and angle) for a specific load, generation and network conditions. We introduce a new seventh-order three-step iterative scheme for obtaining approximate solution of nonlinear systems of equations. We attain the seventh-order convergence by using four function evaluations which makes it worthy of interest. Moreover, we show its applicability to the electrical power system for calculating voltages and phase angles. By calculating the bus angle and voltage level, we conclude that the performance of the power system is assessed in a more efficient manner using the new scheme. In addition, dynamical planes of the methods applied on nonlinear systems of equations show global convergence.
Physical- and Social-Based Rain Gauges—A Case Study on Urban Flood Detection
Authors: Hossaki Vitor Y. , Seron Wilson F. M. S. , Negri Rogério G. , Londe Luciana R. , Tomás Lívia R. , Bacelar Roberta B. , Andrade Sidgley C. , Santos Leonardo B. L.
Published: April 2023

Floods are among the most frequent and costly rainfall-triggered disasters. In this context, geospatial content generated by non-professionals using geolocated systems offers the possibility of monitoring environmental events. This study shows a statistical correlation between in situsensors, radar, Twitter posts, and flooding events. Furthermore, we observed in this study that flooding-related keywords are statistically more significant on flooding days than on non-flooding days and reinforce that Twitter can be employed as a complementary data source for flood management systems.
An Integrated Model for Evaluating the Sustainability of Gamified Mobile Health Apps: An Instrument Development and Validation
Authors: Mustafa Abdulsalam Salihu , Ali Nor’ashikin , Dhillon Jaspaljeet Singh , Sedera Darshana
Published: April 2023

Mobile health (mHealth) apps are designed to support health behavior outcomes and improve well-being. The existing body of literature confirms mHealth’s overall efficacy in promoting physical activity; however, more research on its utility in sustaining user engagement is needed. Understanding the determinants of an individual’s willingness to continue using mHealth is vital to improving the intervention’s success. This study developed a unified model and survey instrument adapted from extant literature while introducing new constructs to predict the sustained use of gamified mHealth. A pilot study was conducted to validate the survey instrument using 48 gamified fitness app users in Malaysia. The survey instrument was tested following rigorous guidelines for quantitative research in the information system context. According to the findings, the reliabilities of most measurement items met the criterion, and those items were retained. Overall, this paper contributes by integrating social comparison theory and the self-determination theory for sustaining user engagement with gamified mHealth through an extrinsic and intrinsic motivation perspective.
Role of Dentistry in Humanitarian Projects: Knowledge and Perspective of Future Professionals on the World of Volunteering in Spain
Authors: Escobedo Martínez Matías Ferrán , Barbeito Castro Enrique , Olay Sonsoles , Suárez-Solis Rodríguez Brezo , Suárez-Solis Rodríguez Juan , Junquera Luis , Mauvezín Quevedo Mario , Junquera Sonsoles
Published: April 2023

Non-governmental organizations (NGOs) in dentistry seek to promote the improvement on oral health in the most disadvantaged regions. The objective of this study is to identify the level of knowledge, expectations, and motivations that dental school students have about volunteering in dentistry, as well as to evaluate possible differences in these variables depending on their level of dental training. During the month of September 2022, a voluntary and anonymous online survey was carried out among all the students at the Dentistry School of Oviedo University. There were 5 questions to judge knowledge about global oral health course. 12 additional questions were included to assess the willingness to volunteer in international setting, the volunteer profile, as well as the most effective means to improve oral health in host communities. None of the students from our center had participated as a volunteer in dental NGOs, but up to 64.4% of them had considered their collaboration. The level of knowledge about global oral health obtained was low, with the percentage of correct answers ranging between 14.4% (in the question about the ideal patient/dentist ratio) and 57.8% (in the question about the fluoride concentration in drinking water). Majority of dental students (98.9%) were not aware that basic package of oral care was created by WHO. Significantly, the students of the clinical courses showed a greater motivation to volunteer.
Combined Study of Transcriptome and Metabolome Reveals Involvement of Metabolites and Candidate Genes in Flavonoid Biosynthesis in Prunus avium L.
Authors: Fu Baochun , Tian Yongqiang
Published: April 2023

Sweet cherry (Prunus avium L.) is a popular fruit tree grown for its juicy fruit and pleasing appearance. The fruit pf the sweet cherry contains active antioxidants and other chemical compounds essential for human health. For this study, we performed the transcriptomics and metabolomics analysis using young Green Peel (GP) and mature Red Peel (RP) from sweet cherries to understand the underlying genetic mechanism regulating fruit development and ripening. Using high-throughput RNA sequencing and ultra-performance liquid chromatography, with quadrupole time-of-flight tandem mass spectrometry, respectively, metabolic and transcript profiling was obtained. Relative to GP, there were equal quantities of pronouncedly varied metabolites in RP (n = 3564). Differentially expressed genes (DEGs, n = 3564), containing 45 transcription factor (TF) families, were recorded in RP. Meanwhile, 182 differentially expressed TF (DETF) members of 37 TF families, were displayed in abundance in RP compared to GP sweet cherries. The largest quantities of DETFs were members of the ERF (25) and basic helix–loop–helix (bHLH) (19) families, followed by the MYB (18), WRKY (18), and C2H2 (12) families. Interestingly, most ERF genes were down-regulated, whereas CCCH genes were mainly up-regulated in RP. Other DETFs exhibited significant variations. In addition, RT-QPCR results and metabolomics data together with transcriptomic data revealed that the abundance of catechin, epicatechin, rhoifolin, myricetin, keracyanin, and the other six glycosyltransferase genes was highly increased in RP when compared to GP sweet cherries. The relatively higher expression of DETFs, metabolite, and flavonoid biosynthesis in RP sweet cherries suggests the accumulation of distinct metabolites that cause red coloring during fruit development and ripening. Thus, the metabolomics and transcriptomic analysis of the current study are powerful tools for providing more valuable information for the metabolic engineering of flavonoids biosynthesis in sweet cherries. They are also helpful in understanding the relationship between genotype and phenotype.
Evaluation of Supply–Demand Matching of Public Health Resources Based on Ga2SFCA: A Case Study of the Central Urban Area of Tianjin
Authors: Guo Xiaoyu , Zeng Suiping , Namaiti Aihemaiti , Zeng Jian
Published: April 2023

Determining whether the supply–demand matching (SDM) of urban public health resources is reasonable involves important issues such as health security and the rational use of resources. Using the central urban area of Tianjin as the research area, this paper used the Gaussian-based 2-step floating catchment area method (Ga2SFCA), combined with multi-source data, and comprehensively considered public medical, natural, and physical resources to evaluate the SDM of single-category and integrated public health resources in the research area. The results showed the following: (1) there was a good fit between supply and demand for public medical and natural health resources in Tianjin’s central urban area. For public physical health resources, there was a poor fit between supply and demand; the population in the supply insufficient and scarce areas for 82.78% of the total and was mainly distributed in the marginal areas of the four districts around the city and the six districts of the inner city. (2) For integrated public health resources, the degree of SDM was generally good. It had a circular structure that gradually shrank from the core to the edge. In order to promote the supply–demand balance of urban public health resources, this paper proposed three strategies involving three aspects: the supply, accessibility, and demand of urban public health resources. These strategies involve the service supply level, urban traffic network and slow traffic, development intensity, and population scale.
Rational In Silico Design of Molecularly Imprinted Polymers: Current Challenges and Future Potential
Authors: Rajpal Soumya , Mishra Prashant , Mizaikoff Boris
Published: April 2023

The rational design of molecularly imprinted polymers has evolved along with state-of-the-art experimental imprinting strategies taking advantage of sophisticated computational tools. In silico methods enable the screening and simulation of innovative polymerization components and conditions superseding conventional formulations. The combined use of quantum mechanics, molecular mechanics, and molecular dynamics strategies allows for macromolecular modelling to study the systematic translation from the pre- to the post-polymerization stage. However, predictive design and high-performance computing to advance MIP development are neither fully explored nor practiced comprehensively on a routine basis to date. In this review, we focus on different steps along the molecular imprinting process and discuss appropriate computational methods that may assist in optimizing the associated experimental strategies. We discuss the potential, challenges, and limitations of computational approaches including ML/AI and present perspectives that may guide next-generation rational MIP design for accelerating the discovery of innovative molecularly templated materials.
Analogies between COVID-19 and Preeclampsia: Focus on Therapies
Authors: Giardini Valentina , Gambacorti-Passerini Carlo , Casati Marco , Carrer Andrea , Vergani Patrizia
Published: April 2023

Preeclampsia is an obstetric pathology with striking similarities to COVID-19. The renin-angiotensin system plays a key role in the pathogenesis of both diseases. This report reviews the pharmacological strategies that have been suggested for the prevention and treatment of preeclampsia and that are potentially useful also in the treatment of COVID-19. Of note, both pathologies have in common an Angiotensin II-mediated endothelial dysfunction secondary to an angiogenic imbalance, with effects on vasculature, coagulation, and inflammation. These considerations are drawn from cases of the initial SARS-CoV-2 primary infection and may not apply to more recent SARS-CoV-2 variants or infections after COVID vaccination. The treatment options discussed included albumin infusion, aspirin, corticosteroids, the monoclonal antibody eculizumab, hydroxychloroquine, low molecular weight heparin, magnesium, melatonin, metformin, nitric oxide, proton pump inhibitors, statins, therapeutic apheresis, and vitamin D.
Diversity of Pholcus Spiders (Araneae: Pholcidae) in China’s Lüliang Mountains: An Integrated Morphological and Molecular Approach
Authors: Zhao Fang-Yu , Yang Lan , Zou Quan-Xuan , Ali Abid , Li Shu-Qiang , Yao Zhi-Yuan
Published: April 2023

Spiders of the genus Pholcus were collected for the first time during an expedition to the Lüliang Mountains in Shanxi Province, North China. Phylogenetic analyses of DNA sequence data from COI, H3, wnt, and 28S genes allowed us to group them into nine well-supported clades. We used morphology and four methods of molecular species delimitation, namely Automatic Barcode Gap Discovery (ABGD), the Generalized Mixed Yule Coalescent (GMYC), Bayesian Poisson Tree Processes (bPTP), and Bayesian Phylogenetics and Phylogeography (BPP), to investigate species boundaries. These integrative taxonomic analyses identified the nine clades as nine distinct species, comprising Pholcus luya Peng & Zhang, 2013 and eight other species new to science: Pholcus jiaocheng sp. nov., Pholcus linfen sp. nov., Pholcus lishi sp. nov., Pholcus luliang sp. nov., Pholcus wenshui sp. nov., Pholcus xiangfen sp. nov., Pholcus xuanzhong sp. nov., and Pholcus zhongyang sp. nov. The species occur in geographic proximity and show many morphological similarities. All of them belong to the P. phungiformes species group. The records from the Lüliang Mountains represent the westernmost distribution limit of this species group.
Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study
Authors: Sassorossi Carolina , Congedo Maria Teresa , Nachira Dania , Tabacco Diomira , Chiappetta Marco , Evangelista Jessica , di Gioia Adele , Di Resta Velia , Sorino Claudio , Mondoni Michele , Leoncini Fausto , Calabrese Giuseppe , Napolitano Antonio Giulio , Nocera Adriana , Lococo Achille , Margaritora Stefano , Lococo Filippo
Published: April 2023

Alveolo-pleural fistula remains a serious post-operative complication in lung cancer patients after surgery, which is associated with prolonged hospital stay and higher healthcare costs. The aim of this study is to evaluate the efficacy of a polyglycol acid (PGA)-sheet known as Neoveil in preventing post-operative air-leak in cases of detected intra-operative air-leak after lung resection. Between 11/2021 and 7/2022, a total of 329 non-small cell lung cancer (NSCLC) patients were surgically treated in two institutions. Major lung resections were performed in 251 cases. Among them, 44 patients with significant intra-operative air-leak at surgery were treated by reinforcing staple lines with Neoveil (study group). On the other hand, a historical group (selected by propensity score matched analysis) consisting of 44 lung cancer patients with significant intra-operative air leak treated by methods other than the application of sealant patches were considered as the control group. The presence of prolonged air-leak (primary endpoint), pleural drainage duration, hospital stay, and post-operative complication rates were evaluated. The results showed that prolonged air-leak (>5 days after surgery) was not observed in study group, while this event occurred in four patients (9.1%) in the control group. Additionally, a substantial reduction (despite not statistically significant) in the chest tube removal was noted in the study group with respect to the control group (3.5 vs. 4.5, p = 0.189). In addition, a significant decrease in hospital stay (4 vs. 6 days, p = 0.045) and a reduction in post-operative complications (2 vs. 10, p = 0.015) were observed in the study group when compared with the control group. Therefore, in cases associated with intra-operative air-leak after major lung resection, Neoveil was considered a safer and more effective aerostatic tool and represents a viable option during surgical procedures.
COVID-19 and Gastrointestinal Disease: Current Insights and Future Management
Authors: Kopel Jonathan , Goyal Hemant
Published: April 2023

The first case of coronavirus disease 2019 (COVID-19) was reported in Wuhan, Hubei Province, China, in December 2019, marking a pivotal moment in human history [...]
Predicting Cardiac Arrest in Children with Heart Disease: A Novel Machine Learning Algorithm
Authors: Yu Priscilla , Skinner Michael , Esangbedo Ivie , Lasa Javier , Li Xilong , Natarajan Sriraam , Raman Lakshmi
Published: April 2023

Background: Children with congenital and acquired heart disease are at a higher risk of cardiac arrest compared to those without heart disease. Although the monitoring of cardiopulmonary resuscitation quality and extracorporeal resuscitation technologies have advanced, survival after cardiac arrest in this population has not improved. Cardiac arrest prevention, using predictive algorithms with machine learning, has the potential to reduce cardiac arrest rates. However, few studies have evaluated the use of these algorithms in predicting cardiac arrest in children with heart disease. Methods: We collected demographic, laboratory, and vital sign information from the electronic health records (EHR) of all the patients that were admitted to a single-center pediatric cardiac intensive care unit (CICU), between 2010 and 2019, who had a cardiac arrest during their CICU admission, as well as a comparator group of randomly selected non-cardiac-arrest controls. We compared traditional logistic regression modeling against a novel adaptation of a machine learning algorithm (functional gradient boosting), using time series data to predict the risk of cardiac arrest. Results: A total of 160 unique cardiac arrest events were matched to non-cardiac-arrest time periods. Using 11 different variables (vital signs and laboratory values) from the EHR, our algorithm’s peak performance for the prediction of cardiac arrest was at one hour prior to the cardiac arrest (AUROC of 0.85 [0.79,0.90]), a performance that was similar to our previously published multivariable logistic regression model. Conclusions: Our novel machine learning predictive algorithm, which was developed using retrospective data that were collected from the EHR and predicted cardiac arrest in the children that were admitted to a single-center pediatric cardiac intensive care unit, demonstrated a performance that was similar to that of a traditional logistic regression model. While these results are encouraging, future research, including prospective validations with multicenter data, is warranted prior to the implementation of this algorithm as a real-time clinical decision support tool.
Association between Estimated Cardiorespiratory Fitness and Abnormal Glucose Risk: A Cohort Study
Authors: Sloan Robert , Kim Youngdeok , Kenyon Jonathan , Visentini-Scarzanella Marco , Sawada Susumu , Sui Xuemei , Lee I-Min , Myers Jonathan , Lavie Carl
Published: April 2023

Background: Cardiorespiratory fitness (CRF) is a predictor of chronic disease that is impractical to routinely measure in primary care settings. We used a new estimated cardiorespiratory fitness (eCRF) algorithm that uses information routinely documented in electronic health care records to predict abnormal blood glucose incidence. Methods: Participants were adults (17.8% female) 20–81 years old at baseline from the Aerobics Center Longitudinal Study between 1979 and 2006. eCRF was based on sex, age, body mass index, resting heart rate, resting blood pressure, and smoking status. CRF was measured by maximal treadmill testing. Cox proportional hazards regression models were established using eCRF and CRF as independent variables predicting the abnormal blood glucose incidence while adjusting for covariates (age, sex, exam year, waist girth, heavy drinking, smoking, and family history of diabetes mellitus and lipids). Results: Of 8602 participants at risk at baseline, 3580 (41.6%) developed abnormal blood glucose during an average of 4.9 years follow-up. The average eCRF of 12.03 ± 1.75 METs was equivalent to the CRF of 12.15 ± 2.40 METs within the 10% equivalence limit. In fully adjusted models, the estimated risks were the same (HRs = 0.96), eCRF (95% CIs = 0.93−0.99), and CRF (95% CI of 0.94−0.98). Each 1-MET increase was associated with a 4% reduced risk. Conclusions: Higher eCRF is associated with a lower risk of abnormal glucose. eCRF can be a vital sign used for research and prevention.
The Impact of Color Vision Deficiency on the Capability of Ophthalmologists to Diagnose Benign and Malignant Choroidal Tumors
Authors: Elfalah Mutasem , AlRyalat Saif Aldeen , Abu-Yaghi Nakhleh E. , Mohammad Mona , AlNawiaseh Ibrahim , Rayyan Deema , Albliwi Moath , Elfalah Mohammad , AlSarairah Fawaz , Yousef Yacoub A.
Published: April 2023

Background: Color vision deficiency (CVD) is an under-reported problem among medical personnel, and its impact is still not well characterized. We aim to assess the impact of CVD among ophthalmologists on the accuracy of diagnosing different benign and malignant choroidal lesions. Methods: This is a cross-sectional study conducted on ophthalmologists. We used a web-based survey to collect responses through professional ophthalmology society social media. The survey included a set of five images for normal fundus, choroidal nevus, circumscribed choroidal hemangioma, choroidal metastasis, and choroidal melanoma, wherein each image simulated the three main types of CVD: protanopia, deuteranopia, and tritanopia, in addition to a non-simulated image. Results: Forty-one participants were included, with a mean age of 40 (±9.2) years. They were 28 (68%) men and 13 (32%) women. Participants showed significantly low accuracy for definite diagnosis for circumscribed choroidal hemangioma, nevus, melanoma, and metastasis when the images simulated protanopia and deuteranopia, but not tritanopia. Nevertheless, participants maintained the capability to recognize the nature of the lesions for both simulated and non-simulated images if they were benign or malignant, thereby ensuring immediate referral for specialized care. The exception was with simulated choroidal nevi images, wherein participants incorrectly assigned simulated protanopia and deuteranopia nevi images to malignant lesions. Conclusion: Protanopia and deuteranopia affected the accuracy of diagnosing several choroidal lesions; however, ophthalmologists with those two simulated CVDs were still able to discriminate between benign and malignant tumors.
The Influence of External Breast Prostheses on the Body Postures of Women Who Have Undergone Mastectomies
Authors: Koralewska Anna , Domagalska-Szopa Małgorzata , Siwiec Jan , Szopa Andrzej
Published: April 2023

Most women who have had a mastectomy and have not opted for breast reconstruction choose to use an external breast prosthesis. This study aimed to assess the impacts of external breast prostheses on the body postures of women after unilateral mastectomies. An additional aim was to identify whether postural asymmetry depended on the side of mastectomy. This study involved 52 women after unilateral mastectomy and consisted of two parts: (1) anthropometric measurement and (2) assessment of body posture using the moiré topography method. The posturometric indices showed that the body posture of the subjects in the sagittal plane is characterized by forward trunk inclination and a tendency to excessive kyphosis. There were no significant differences between parameters characterizing body posture with and without external breast prosthesis. The lack of external breast prosthesis had a significant effect only on excessive forward trunk inclination. Significant differences were found in the posturometric parameters in the transverse plane between the groups of patients after left- and right-sided mastectomy. The obtained results did not fully confirm the hypothesis that the external breast prosthesis affects the body posture of women after unilateral mastectomy.
Investigation of the Characteristics of MAO Coatings Formed on Ti6Al4V Titanium Alloy in Electrolytes with Graphene Oxide Additives
Authors: Grigoriev Sergey , Peretyagin Nikita , Apelfeld Andrey , Smirnov Anton , Rybkina Alevtina , Kameneva Ekaterina , Zheltukhin Artem , Gerasimov Mikhail , Volosova Marina , Yanushevich Oleg , Krikheli Natella , Peretyagin Pavel
Published: April 2023

Coatings with a thickness from ~40 to ~50 µm on Ti6Al4V titanium alloy were formed by micro-arc oxidation in a silicate-hypophosphite electrolyte with additions of graphene oxide. Micro-arc oxidation treatment was carried out in the anode–cathode mode (50 Hz) with a ratio of anode to cathode currents of 1:1, a total density of 20 A/dm2, and a treatment duration of 30 min. The effect of the graphene oxide concentration in electrolytes on the thickness, roughness, hardness, surface morphology, structure, composition of micro-arc oxidation coatings, and its electrochemical corrosion behavior in 3.5% NaCl solution was studied. The input of graphene oxide additives into the base silicate hypophosphite electrolyte led to an increase in the hardness of micro-arc oxidation coatings. Electrochemical polarization studies and impedance data showed that the best characteristics in terms of corrosion-protective ability among coatings formed in electrolytes with graphene oxide additives were those formed in the electrolyte with a graphene oxide concentration of 0.1 g·L−l. A further increase in the graphene oxide concentration in the electrolyte did not improve the protective properties of micro-arc oxidation coatings.
Physical and Chemical Foam Injection Moulding of Natural-Fibre-Reinforced Polypropylene—Assessment of Weight-Reduction Potential and Mechanical Properties
Authors: Mihalic Matthias , Pretschuh Claudia , Lummerstorfer Thomas , Unterweger Christoph
Published: April 2023

Reducing weight not only consumes fewer resources for manufacturing but also requires less energy for transportation, thus preserving resources and reducing CO2 emissions. The latter part is of utmost importance in mobility applications. For example, in the automotive industry, the large-scale production of lightweight structural parts is becoming a main issue. An effective method to meet these requirements is foam injection moulding. In this study, physical (MuCell technology) and chemical foam injection moulding was used to produce plates made from wood-fibre- and cellulose-fibre-reinforced polypropylene, respectively. For both technologies, the used core-back method enabled precise mould opening during injection and thus allowed for variation in the plate thickness and density. The simpler short-shot technology, used only for the chemical foaming trials with differing shot volumes, provided plates with constant thicknesses. The foam structure and finally the mechanical properties of the plates depended on the filler type, the foaming method and the density. The latter was directly linked to either the plate thickness or the shot volume. Physical foaming appeared to be slightly more effective regarding the achievable density reduction (up to 37% reduction), but the physically foamed parts had worse mechanical properties at equal density than their chemically foamed counterparts. Besides the comparison of different foaming methods, this study provides the tensile, flexural and impact properties of natural-fibre-reinforced polypropylene composites over a wide density range, thus offering a good basis for evaluating weight-saving potential for various applications.
Evaluation Method for Energy Saving of Sail-Assisted Ship Based on Wind Resource Analysis of Typical Route
Authors: Ma Ranqi , Wang Zhongyi , Wang Kai , Zhao Haoyang , Jiang Baoshen , Liu Yize , Xing Hui , Huang Lianzhong
Published: April 2023

Sail-assisted technology can reduce greenhouse-gas emissions by saving the energy consumption of ships with wind energy utilization. The distribution characteristics of marine wind resources are critical to the energy-saving effect of sail-assisted ships. However, due to the lack of effective energy-saving evaluation methods for improving the utilization rate of wind energy, a high potential for wind energy utilization still exists. A novel energy-saving evaluation method based on the wind energy resource analysis of typical ship routes is proposed in this paper. First, a three-degree-of-freedom motion model for sail-assisted ships considering the wing sail forces is constructed. Then, a wind resource acquisition and analysis method based on spatial–temporal interpolation is proposed. On this basis, the wind field probability matrix and wing sail force matrix are established. Ultimately, an energy-saving evaluation method for sail-assisted ships on typical routes is proposed by combining the sailing condition of ships. The case study results show that the energy-saving effect of a wing sail-assisted oil tanker that sailed on the China-to-Middle East route was more than 5.37% in 2021 and could reach 9.54% in a single voyage. It is of great significance to realize the popularization and application of sail-assisted technology, thus improving the greenization of the shipping industry.
Correction: Moss, R.B. Severe Fungal Asthma: A Role for Biologics and Inhaled Antifungals. J. Fungi 2023, 9, 85
Authors: Moss Richard B.
Published: April 2023

In the original publication [...]
Trends in Availability of Genetic Tests in the United States, 2012–2022
Authors: Halbisen Alyssa L. , Lu Christine Y.
Published: April 2023

Globally, genetic testing has become increasingly used over the last two decades. As a result of the rapid development of genetic tests, the Genetic Testing Registry was created in the United States to provide transparent information on genetic tests and the corresponding laboratories. Using publicly available data from the Genetic Testing Registry, we analyzed trends in the availability of genetic tests in the United States over the last decade. As of November 2022, a total of 129,624 and 197,779 genetic tests in the US and globally, respectively, including updated versions of previously existing tests, have been made available and submitted to the genetic testing registry. Over 90% of tests submitted to GTR are for clinical rather than research purposes. Worldwide, 1081 and 6214 new genetic tests had been made available in 2012 and in 2022, respectively. In 2012, only 607 and in 2022, 3097 new genetic tests were made available in the US, with 2016 seeing the biggest increase in availability of new tests during the study period. Over 90% of tests can be used for diagnosis. In the US, 10 of >250 laboratories account for 81% of new genetic tests in GTR. As more genetic tests become available, further international collaboration is required for a comprehensive understanding of the available genetic tests worldwide.
Monitoring Thermoregulation Patterns in Asian Elephants (Elephas maximus) in Winter Months in Southwestern Ontario Using Infrared Thermography
Authors: Lefebvre Janel , Gray Charlie , Prosser Taryn , Chabot Amy
Published: April 2023

Given the current and future threats to Asian elephants (Elephas maximus), maintaining a sustainable ex situ population is crucial for the longevity of the species. Using Infrared Thermography (IRT), thermoregulation of Asian elephants at low ambient temperatures was examined. Thermal images were taken at 15 min intervals over 60–90-min observation periods, once weekly, during January and February 2022. A total of 374 images were examined from 10 Asian elephants, which varied from 1 to 56 years of age. Data from thermograms of the ear and body were interpreted in view of weight, age and behavior. Variability in surface temperature was found most frequently in the ears, occasionally presenting as thermal windows—areas with dense underlying blood supply that aid in heat exchange. Thermal windows occurred most frequently in the distal, then medial, regions of the ear. The pattern of appearance of thermal windows in the ear provides support that the increase of blood flow is utilized as a method of warming. This preliminary study provides key insight into Asian elephant thermoregulation, suggesting that the species may be more well-adapted to lower ambient temperatures than previously thought.
A Comprehensive Review on E-Waste Management Strategies and Prediction Methods: A Saudi Arabia Perspective
Authors: Madkhali Hatim , Duraib Salahaldeen , Nguyen Linh , Prasad Mukesh , Sharma Manu , Joshi Sudhanshu
Published: April 2023

Electronic waste generation is increasing dramatically throughout the world. Consequently, this increase in E-waste harms the environment, health, and other aspects of human life. Moreover, hazardous substances and the informal disposal of E-waste severely threaten human health and the environment. Saudi Arabia is the largest Arab country in terms of electronic waste generation and is the Arab country that generates the most E-waste. Over the past few decades, several initiatives and policy implementations have been undertaken in the country. However, the management of E-waste is still a source of distress and an unresolved issue. Sustainable development requires much more effort, primarily efficient E-waste management, which can only be achieved by establishing a formal collection system, early forecasting, and accurate estimations. The purpose of this study is to provide an overview of the fundamental and emerging trends in E-waste production worldwide and in Saudi Arabia. This paper aims to summarize the hazardous elements present in E-waste, their dangerous effects, and the economic potential for recycling E-waste as a means of developing sustainable communities. This study explores the practices regarding efficient E-waste management and E-waste estimation and prediction globally, specifically in Saudi Arabia and other Arab countries. This study suggests that more than the use of a single management probe will be needed to achieve significant results. Instead, a complementary approach can be used to achieve the most effective results. Additionally, people should be aware of the importance of handling and recycling E-waste. This study emphasizes the importance of formal collection and documentation to ensure effective monitoring and sustainable development in any developed country.
A Public Participation GIS for Geodiversity and Geosystem Services Mapping in a Mountain Environment: A Case from Grayson County, Virginia, U.S.A.
Authors: Stanley Kyler B. , Resler Lynn M. , Carstensen Lawrence W.
Published: April 2023

Geodiversity and geosystem services are essential concepts for conservation efforts in mountain regions. Approaches that integrate both natural and human dimensions of mountain abiotic nature are best suited for this purpose; however, geodiversity research and associated conservation efforts along this vein are still developing. Here, we explore the potential of a public participation GIS, which integrates qualitative surveys with quantitative geodiversity information, to assess possible relationships between geodiversity and geosystem services for Grayson County, Virginia, U.S.A. Specifically, we: (1) used a geodiversity index to model geodiversity for the study area, (2) used a public participation GIS to map geosystem services markers, and (3) visualized geodiversity–geosystem services hotspots to uncover potential relationships between geodiversity and geosystem services values. Participants placed 318 markers, most frequently representing aesthetic (32%), artistic (22%), and educational (15%) geosystem services values. The majority (55%) of these markers corresponded to low and very low quantitative geodiversity index scores. Geosystem services value markers were clustered around population centers and protected areas. Although quantitative geodiversity measures are often used to identify and prioritize areas for conservation, our results suggest that locations valued by respondents would be missed using quantitative metrics alone. This research thus supports the need for holistic approaches incorporating place values to conserve and best understand relationships between people and abiotic aspects of mountain landscapes.