bluuebunny/crossref_metadata_2025 huggingface dataset:
Randomized controlled clinical trial comparing the efficacy and tolerability of aripiprazole and sodium valproate in the treatment of Tourette syndrome
Authors: Tao Deshuang , Zhong Tangwu , Ma Shuxia , Li Jialin , Li Xiaojie
Published: October 2019

Objective

This study compared the efficacy and tolerability of sodium valproate and aripiprazole in the treatment of Tourette syndrome (TS).

Method

24 children and adolescents with a diagnosis of TS from the Jiamusi Central Hospital between January 2014 and August 2017 were randomly divided into sodium valproate group and aripiprazole group according to the order of clinic visits and treated for 10 days. Tic severity was rated using the Yale Global Tic Severity Scale (YGTSS) and the Clinical Global Impressions Scale for tics (CGI-Tics) and the adverse reactions were valued using the Treatment Emergent Symptom Scale (TESS) at baseline and at each follow-up visit.

Results

The TTS score in the YGTSS scale decreased over time in both groups while the aripiprazole group was significantly higher on the 5th day (p < 0.05) and 10th day (p < 0.05) than the sodium valproate group. There was no significant difference in TESS score between the two groups.

Conclusions

The study indicates that the patients treated with sodium valproate injection have a faster onset time than the patients treated with oral aripiprazole in controlling tics.
Correction to: Soybean iron deficiency chlorosis high throughput phenotyping using an unmanned aircraft system
Authors: Dobbels Austin A. , Lorenz Aaron J.
Published: October 2019

In the original article [1], under the subheading “Image data processing”, last paragraph, last sentence that reads as “The least …… data collection” was incorrectly published. The correct sentence should read as “Least-significant differences (P < 0.20) were calculated for all 36 trials on both ground-based and UAS-image based scores for both dates of data collection.” The original article has been corrected.
MicroRNAs’ control of cancer cell dormancy
Authors: Ruksha Tatiana G.
Published: October 2019

‘Dormancy’, in the context of carcinogenesis, is a biological phenomenon of decreased cancer cell proliferation and metabolism. In view of their ability to remain quiescent, cancer cells are able to avoid cell death induced by chemotherapeutic agents, and thereby give rise to tumor relapse at a later stage. Being a dynamic event, the dormant state is controlled by several epigenetic mechanisms, including the action of microRNAs. The present review highlights microRNAs that have been shown to be dysregulated in dormant cancer cells among different tumor types. MicroRNAs accomplish their control of cancer cell quiescence by targeting cell cycle regulators and signaling pathways involved in cell growth maintenance, including the AKT/phosphoinositide 3-kinase (PI3K) pathway. MicroRNAs, as components of intercellular vesicles, enable interactions to occur between cancer cells and cells of the microenvironment, resulting in the cancer cells either acquiring the quiescent state or, oppositely, stimulating them to proliferate. Taken together, the evidence obtained to date has collectively confirmed the involvement of microRNAsin cancer cell dormancy. Modulation of the various processes may enable optimization of the treatment of metastatic tumors.
Dose-volume analysis of predictors for acute anal toxicity after radiotherapy in prostate cancer patients
Authors: Peng Xingsi , Zhou Sha , Liu Shiliang , Li Jibin , Huang Sijuan , Jiang Xiaobo , Lin Maosheng , Huang Shaomin , Lin Chengguang , Qian Chaonan , Liu Mengzhong , He Liru
Published: October 2019

Background

This study aimed to evaluate the clinical and dosimetric factors predictive of acute anal toxicity (AAT) after radiotherapy in prostate cancer (PCa) patients with or without hemorrhoids.

Methods

We analyzed data from 347 PCa patients (248 cases treated from July 2013 to November 2017 for training cohort and 99 cases treated in 2018 for validation cohort) treated with pelvic radiotherapy at a single institution. Anal canal dose–volume histogram was used to determine the prescribed dose. Univariate and multivariate analyses were used to evaluate the risk of AAT as a function of clinical and dosimetric factors.

Results

Totally, 39.5% (98/248) and 31.3% (31/99) of the PCa patients developed AAT in training and validation cohorts, respectively. The incidence of AAT was much higher in patients with hemorrhoids than in those without hemorrhoids in both training and validation cohorts. Hemorrhoids and volume received more than 20 Gy (V20) were valuated as independent factors for predicting AAT in training cohort. Similar results were also observed in our validation cohort. The combination of hemorrhoids and high anal canal V20 (> 74.93% as determined by ROC curves) showed the highest specificity and positive predictive values for predicting AAT in both training and validation cohorts.

Conclusions

AAT occurs commonly in PCa patients with hemorrhoids during and after pelvic radiotherapy. Hemorrhoids and anal canal V20 are independent predictors of AAT. These factors should be carefully considered during treatment planning to minimize the incidence of AAT.
Generalizations of Troisi’s inequality in weighted p-Sobolev spaces with singularities
Authors: Chen Hua , Luo Yong , Wang Jing
Published: October 2019

We extend classical Troisi’s inequality to the weighted p-Sobolev spaces on stretched cone, edge, and corner respectively. The results here can be used to investigate anisotropic elliptic equations involving cone degeneracy, edge degeneracy, and corner degeneracy, which will be studied in our forthcoming papers.
Emerging resistance of van genotype in enterococci: A potential menace for therapeutic failure
Authors: Ejaz Hasan
Published: October 2019

Objectives: Emerging cases of vancomycin-resistant enterococci (VRE) are detrimental for the patients. The current study aimed to ascertain the occurrence of VRE, their antibiogram and the van genotype responsible for vancomycin resistance.

Methods: A total number of 2,958 clinical specimens were processed at Microbiology Department of the Alrazi Health Care, Lahore during the one year (2016-2017) using microbiological culture media, biochemical and serology. Antibiogram of enterococcal strains was performed using disc diffusion and E-test. ATCC Enterococcus faecalis 29212 was used as a quality control strain. The detection of van genotypes was accomplished by multiplex PCR assay.

Results: Out of the 147 enterococci, 139 (94.6%) were E. faecalis, and 8 (5.4%) were E. faecium. Statistically significant associations of urine (p < 0.001), pus (p < 0.001) and wound swabs (p = 0.001) were observed with E. faecalis. A significant correlation of enterococcal infections (p = 0.05) was seen with female patients. Four (2.9%) strains of E. faecalis found to be VRE with vanB (75%) and vanA (25%) genotypes.

Conclusion: The emerging strains of VRE (vanB and vanA genotype) in the current study are a potential menace for therapeutic failure, which left the physicians with only linezolid as a therapeutic option.

doi: https://doi.org/10.12669/pjms.35.6.1145

How to cite this:Ejaz H. Emerging resistance of van genotype in enterococci: A potential menace for therapeutic failure. Pak J Med Sci. 2019;35(6):1659-1663. doi: https://doi.org/10.12669/pjms.35.6.1145

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The safety and efficacy of biologic agents in treatment of systemic lupus erythematosus: A network meta-analysis
Authors: Tao Meng-Jun , Cheng Ping , Jin Lai-Run , Zhou Jun , Shi Wei , Peng Hui , Xu Liang , Li Zhi , Yuan Hui
Published: October 2019

Objective: Previous studies have shown that biologic agents out of the nine medicines might be beneficial for the treatment of SLE. The aim of this study was to evaluate the most effective medication of six biologic agents in treatment of SLE using network meta-analysis (NMA). The performance of these processes is ranked according to the results of this analysis.

Methods: Multiple databases including PubMed, EMBASE and Cochrane Library was used to identify applicable articles and collect relevant data to analyzed by using STATA (13.0) software. The papers included in this study were divided into control group (placebo) and observation group (one of the six medicines).

Results: A total of 21 eligible RCTs of biologic agents were identified, a total of 995 papers were included, and the results showed that the belimumab had the highest probability of being the most clinically efficacious intervention, with a surface under the cumulative ranking (SUCRA) curve of 75.0, was significantly superior (P < 0.05) to placebo alone. The blisibimod was the worst, with a SUCRA value of 29.4. The other biologic agents (atacicept, blisibimod, epratuzumab, rituximab, tabalumab) were insignificantly superior (P > 0.05) to placebo alone.

Conclusions: Belimumab had the highest probability of being the best treatment for SLE compared with the other biologic agents (atacicept, blisibimod, epratuzumab, rituximab, tabalumab). The other biologic agents indicated an insignificant difference in efficacy for the treatment of SLE compared with placebo.

doi: https://doi.org/10.12669/pjms.35.6.771

How to cite this:Tao MJ, Cheng P, Jin LR, Zhou J, Shi W, Peng H, et al. The safety and efficacy of biologic agents in treatment of systemic lupus erythematosus: A network meta-analysis. Pak J Med Sci. 2019;35(6):1680-1686. doi: https://doi.org/10.12669/pjms.35.6.771

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Effect of altering the regime of oral rifampicin therapy in the treatment of persistent central serous chorioretinopathy
Authors: Loya Hina , Ghoghari Hunain , Rizvi Syed Fawad , Khan Abdullah
Published: October 2019

Objective: To study the effect of reducing the duration of rifampicin therapy in the treatment of Chronic Central Serous Chorioretinopathy.

Methods: This is interventional study conducted in Layton Rahmatullah Benevolent Trust, Free Base Eye Hospital Korangi, Karachi from February 2017 - December 2018. This randomized controlled comparative study included two groups, Groups-A comprised of 48 eyes of 40 cases with Chronic Central Serous Chorioretinopathy who were given reduced dose of oral rifampicin i.e. 600mg for one month, and Group-B consisted of 43 eyes of 40 controls with Chronic Central Serous Chorioretinopathy who were given reduced dose of oral rifampicin i.e. 300mg once daily for three months as previously stated in literature. To access the effect of therapy in both the groups, pre-treatment visual acuity on the logMAR and Optical Coherent Tomography (OCT, Heidelberg spectralis) for CMT were performed and repeated on the 1st and 3rd month post-treatment. Patients were also followed for 6 months to access any recurrence.

Results: On comparing the two groups, Group-A had improvement in VA and CMT after one month therapy of Rifampicin, Pre-treatment mean VA in Group-A was 0.85 ± 0.19 as compared to the pre-treatment mean VA in Group-B i.e. 0.74+/- 0.208, while the pre-treatment mean CMT was 609.0 ± 178.29 µm in Group-A, and 600.0 +/- 155.09 µm in Group-B respectively. After 1 month of therapy, the visual status, and CMT in Group-A was 0.29+/- 0.21 and 311.6 +/- 89.9, while Group-B, VA was 0.598 +/- 0.23 (p value 0.001%) and CMT was 512.30 +/- 148.37 (p-value 0.001%). Rifampicin was continued in Group-B till three months, and patients were re-accessed but there was no difference in VA and CMT statically. During the 3rd and 6th months of follow up no relapses were reported.

Conclusion: This comparative study showed that the group receiving oral rifampicin 600mg for one month showed better outcome at one month and third month than the group receiving oral rifampicin at a dose of 300mg once daily for three months. This gives a better compliance and lower the risk of drug induced side effects.

doi: https://doi.org/10.12669/pjms.35.6.990

How to cite this:Loya H, Ghoghari H, Rizvi SF, Khan A. Effect of altering the regime of oral rifampicin therapy in the treatment of persistent central serous chorioretinopathy. Pak J Med Sci. 2019;35(6):1687-1690. doi: https://doi.org/10.12669/pjms.35.6.990

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The Economics of Line-Sitting
Authors: Cui Shiliang , Wang Zhongbin , Yang Luyi
Published: October 2019

This paper studies an emerging business model of line-sitting in which customers seeking service can hire others (line-sitters) to wait in line on behalf of them. We develop a queueing-game-theoretic model that captures the interaction among customers, the line-sitting firm, and the service provider to examine the impact of line-sitting on the service provider’s revenue and customer welfare. We also contrast line-sitting with the well-known priority purchasing scheme, as both allow customers to pay extra to skip the wait. Our main results are as follows. First, we find that both accommodating line-sitting and selling priority can bring in extra revenue for the service provider, although by different means—selling priority increases revenue mainly by allowing the service provider to practice price discrimination that extracts more customer surplus, whereas line-sitting does so through demand expansion, attracting customers who would not otherwise join. Second, the priority purchasing scheme tends to make the customer population worse off, whereas line-sitting can be a win–win proposition for both the service provider and the customers. Nevertheless, having the additional option of hiring line-sitters does not always benefit customers as a whole because the demand expansion effect also induces negative congestion externalities. Finally, despite the fact that the service provider collects the priority payment as revenue but not the line-sitting payment, which accrues to the third-party line-sitting firm, we demonstrate that, somewhat surprisingly, accommodating line-sitting can raise more revenue for the service provider than directly selling priority.

This paper was accepted by Charles Corbett, operations management.
Collateral, Ease of Repossession, and Leases: Evidence from Antirecharacterization Laws
Authors: Chu Yongqiang
Published: October 2019

This paper studies how the ease of repossessing collateral in bankruptcy affects corporate leasing policy. Using plausibly exogenous variation of the ability to repossess assets generated by state antirecharacterization laws, I find that the antirecharacterization laws, which make collateral repossession easier for secured lending, reduces corporate leasing. Consistent with the argument that only financially constrained firms value additional debt capacity because of the increased ability to repossess assets, I find that the effect concentrates in financially constrained firms. I also find that the effect is much stronger for firms with less specific assets. In addition, I find that the laws also affect leverage, cash holding, and corporate investment.

This paper was accepted by Gustavo Manso, finance.
Rare health condition 28: Ehlers-Danlos syndrome; Alpers disease; prevalence and incidence
Authors: Barber Chris
Published: October 2019

The purpose of this series is to highlight a range of rare health conditions: those that affect no more and usually fewer than 1 person in every 2000. Many healthcare assistants and nurses will encounter some of these conditions, given the high number of them. This 28th article will briefly explore two of these conditions—Ehlers-Danlos syndrome (EDS) and Alpers disease—as well as the meaning of and similarities and differences between ‘incidence’ and ‘prevalence’.
Vascular endothelial function is improved after active mattress use
Authors: Baker Gary , Bloxham Saul , Laden Joe , Gush Rodney
Published: October 2019

Objective:

Active mattresses are used to prevent, treat and relieve pressure ulcers (PU) by intermittent contact pressure/relief. However, no studies have directly assessed the vascular endothelial response to long-term active mattress use. This study investigated the hypothesis that eight weeks use of an active mattress would lead to improvements in vascular endothelial function in healthy participants.

Methods:

Physiological parameters of baseline skin temperature (BskT), resting blood flow (RBF) and endothelial function as measured using post-occlusive reactive hyperaemia (PORH), were assessed at baseline (week 0); following eight weeks of sleeping on an active mattress, and after an eight week washout period (at week 16).

Results:

We recruited 10 healthy participants (four male, age 52.7±8.5 years, six female age 51.8±17.5 years). Following active mattress use RBF, PORH and BskT at the hallux pulp increased by 336%, 197% and 3.5ºC, respectively. Mean values increased from 24.3±38.3 perfusion units to 106.0±100.3 perfusion units (p=0.021) and from 13,456±10,225 to 40,252±23,995 perfusion units x seconds (p=0.003) and from 22.9±2.5ºC to 26.4±1.9ºC (p<0.001), respectively.

Conclusion:

Active mattress use for eight weeks leads to significant improvements in RBF, PORH, and BskT. These results suggest that active mattress use can improve endothelial function. Future research is required to explore the potential of active mattress use in the treatment and management of diseases and conditions that would benefit from an improved endothelial function.
Clinical efficacy of biocellulose, carboxymethyl cellulose and normal saline dressing in epidermolysis bullosa
Authors: Dwiyana Reiva Farah , Yogya Yuri , Gondokaryono Srie Prihianti , Diana Inne Arline , Suwarsa Oki , Ramali Lies Marlysa , Sutedja Eva Krishna , Rahardja July Iriani , Gunawan Hendra
Published: October 2019

Objective:

To evaluate the efficacy of a biocellulose, a carboxymethyl cellulose and a normal saline wound dressing in the wound care management of epidermolysis bullosa (EB) skin wounds.

Methods:

This was a single-blind, randomised controlled trial involving wounds from patients with EB. Wounds were divided into three groups: group I with biocellulose wound dressing, group II with carboxymethyl cellulose wound dressing and group III with normal saline wound dressing as a control. All dressing changes and wound parameters were recorded. Observations were conducted every three days until complete wound closure or up to one month.

Results:

The outcomes of treatment of 36 wounds from four patients were evaluated in this study. Mean healing time in group I was seven days, eight days in group II and 14 days in group III. There were significant differences in healing times between group I and group III (p=0.0001) and between group II and III (p=0.001). The results showed a significant reduction in the percentage of wounds area on day three for each group: 51.7% in group I, 51.9% in group II, and 26% for group III. All wounds in groups I and II had healed at day 12 (100%) and at day 24 (100%) in group III. There were significant differences in the reduction of percentage wound area between group I and group III at day three (p=0.044) and day six (p=0.000), and between group II and III at day six (p=0.003).

Conclusion:

The study demonstrates that both the biocellulose and the carboxymethyl cellulose wound dressings significantly reduced percentage wound areas and complete healing times compared with the normal saline wound dressing in EB skin wounds, demonstrating they are both equally good for wound care management in EB patients.
Mock abstracts with mock findings: a device to catalyse production, interpretation and use of knowledge outputs in a university-policy-practice research partnership
Authors: Hawe Penelope , Conte Kathleen P. , Groen Sisse , Loblay Victoria , Green Amanda , Innes-Hughes Christine , Milat Andrew , Persson Lina , Mitchell Jo , Thackway Sarah , Williams Mandy
Published: October 2019

Background:

A number of ways to conduct research are designed to maximise the likelihood that evidence from research is quickly transferred into practice. This includes action research and partnership research between researchers and policy makers. Such approaches focus research effort on questions of highest relevance to practice and policy so as to create ownership of the results. However, such approaches on their own do not necessarily visualise or illuminate possible pathways of action or create a sense of personal connection to these possible actions.

Aims and objectives:

Our intent is to foster high-level engagement with possible project findings by policymakers and researchers involved in partnership research. We describe a simple, creative, innovative device: production of co-authored mock (i.e., fake) in-house abstracts of peer reviewed papers as an aid in this process This occurs in advance of knowing real results of the study. The fake abstracts process described here occurs within a research-policy maker-practitioner partnership studying the scaling-up of childhood statewide obesity prevention programs and the electronic monitoring system being used to track progress.

Key conclusions:

The fake abstracts are a tool for identifying priority interests among a large data set. They act as a trigger to uncovering different interpretations of findings among the team. They foster discussion and mental rehearsal of actions based on different scenarios. And they help the team coordinate participation in the analysis and writing-up of the real findings. They also represent a hypothetical variety of research endpoints which also assist with maintaining project momentum during long phases of analysis.
Tumor-Associated Release of Prostatic Cells into the Blood after Transrectal Ultrasound-Guided Biopsy in Patients with Histologically Confirmed Prostate Cancer
Authors: Joosse Simon A , Beyer Burkhard , Gasch Christin , Nastały Paulina , Kuske Andra , Isbarn Hendrik , Horst Ludwig J , Hille Claudia , Gorges Tobias M , Cayrefourcq Laure , Alix-Panabières Catherine , Tennstedt Pierre , Riethdorf Sabine , Schlomm Thorsten , Pantel Klaus
Published: October 2019

BACKGROUND

Transrectal ultrasound-guided prostate biopsy (TRUS) is a standard procedure for prostate cancer diagnosis. Because prostate cancer is a multifocal disease in many patients, multiple sampling (n ≥ 10) is required, which may bear the risk of systemic spread of cancer cells.

DESIGN

Using the standardized CellSearch® system that allows for the detection of single epithelial cell adhesion molecule-positive circulating tumor cells (CTCs) in blood, we investigated whether prostate biopsy is associated with release of prostatic tumor cells into the circulation. Peripheral blood was obtained before and within 30 min after performing prostate biopsy from 115 men with increased serum prostate-specific antigen.

RESULTS

The number of CTCs significantly increased after biopsy in men with histologically confirmed prostate cancer (odds ratio, 7.8; 95% CI, 4.8–12.8), whereas no biopsy-related changes could be detected in men without confirmed prostate cancer. Multivariable analysis showed that biopsy-related increase of CTCs was significantly correlated with a worse progression-free survival (hazard ratio, 12.4; 95% CI, 3.2–48.6) within the median follow-up of 41 months.

CONCLUSIONS

Prostate biopsies may lead to a tumor-associated release of CTCs into the blood circulation. Larger confirmatory trials with longer follow-up periods are required before any change in clinical practice can be recommended.
Identidade do ser enfermeiro na perspectiva de graduandos de enfermagem
Authors: Araujo da Silva Thais
Published: October 2019

Este artigo tem como objetivo compreender as percepções e significados atribuídos à identidade do ser enfermeiro na perspectiva de estudantes de Enfermagem, em uma Instituição de Ensino Superior privada, do município de São Paulo. Foi feita uma investigação exploratória, utilizando o método da História Oral Temática. Sendo assim, foram entrevistados quinze graduandos de Enfermagem, no ano de 2015, cujos discursos foram analisados sob a ótica de Claude Dubar. Percebeu-se que, mesmo sendo ingressantes e alguns já serem profissionais da área como auxiliares e/ou técnicos de enfermagem, os aspectos relacionados à identidade profissional em certos momentos caracterizaram crises, cujos discursos trouxeram enunciados reveladores de ambiguidades relacionadas ao trabalho do enfermeiro e do reconhecimento de seu papel perante a sociedade, como aqueles discursos que retrataram conotações idealistas do ser enfermeiro (missão, vocação, dedicação, dentre outros).
Escalas para medir necesidades de cuidado en pacientes, familia y profesionales que se enfrentan al final de la vida en la UCI
Authors: Hernandez-Zambrano Sandra Milena , Carrillo-Algarra Ana Julia , Torres-Pachon Lady Bibiana , Herrera-Cristancho Dely Marcela
Published: October 2019

Introducción: Las necesidades que se generan al final de la vida, pueden influenciar no solo la salud física sino en la emocional, psicológica y espiritual de quienes conviven en un entorno de cuidado crítico. Objetivo: Describir las escalas que permitan determinar las necesidades de cuidado en pacientes, familia y profesionales que se enfrentan al final de la vida en la UCI. Método: Revisión integradora de la literatura. Se realizó una búsqueda en las bases de datos: PubMed, CINAHL, CUIDEN, Ovid, Epistemonikos, BVS, EBMR, repositorios y análisis de referencias cruzadas. Resultados: Tras el proceso realizado de lectura crítica 13 artículos cumplían con criterios de inclusión: 4 validaciones psicométricas, 2 revisiones sistemáticas y 7 estudios cuantitativos descriptivos. Los resultados se clasificaron en tres categorías: instrumentos de medición para pacientes, familia y profesionales.Discusión: Se encontró dentro de la categoría instrumentos de medición de necesidades enfocada a la familia 27 escalas, la más conocida la CCFNI. Para pacientes se identificó una gran trayectoria investigativa de medición de necesidades utilizando la escala CARE-Q. En cuanto a los profesionales de la UCI no hay evidencia de una escala que mida las necesidades más allá de las laborales.
Cuidados de enfermería en pacientes pediátricos con quemaduras y efectos por separación del vínculo familiar
Authors: Padrón Fernández Lidys , Álvarez González Arelys Rebeca , Cedeño Cedeño María Mercedes
Published: October 2019

Introducción: Uno de los principales problemas de salud en la edad infantil lo constituyen las quemaduras, consideradas un evento frecuente pero prevenible, que conlleva a una estancia hospitalaria, en muchas ocasiones prolongada, que puede ocasionar efectos en el niño por la separación del vínculo familiar. El profesional de enfermería, encargado de la atención del niño, debe enfocar sus cuidados de una manera integral y tomando en consideración las esferas físicas, biológicas y psicológicas. Objetivo: Determinar los cuidados de enfermería en pacientes pediátricos con quemaduras y los efectos por separación del vínculo familiar en el Hospital “Baca Ortiz” de Quito, Ecuador. Método: Investigación descriptiva, cuantitativa, no experimental. Población de estudio: De un total de 72 profesionales de la enfermería, se seleccionaron 40 enfermera(o)s que laboran en el Servicio de Quemado. Como método de recolección de información se aplicó una encuesta. Los resultados se exponen en tablas de frecuencia absoluta y porcentaje. Resultados: Se constata el cumplimiento de los cuidados relacionados con la hidratación de la piel, el control del balance hidroelectrolítico, la estimulación del niño y la familia y los efectos que experimentan los pacientes pediátricos por separación del vínculo familiar, dentro de los cuales se encuentran la ruptura de roles y angustia, así como los trastornos por somatización y el estrés agudo. Conclusiones: Se aprecian dificultades en el establecimiento de cuidados en pacientes pediátricos con quemaduras y los efectos por separación del vínculo familiar, lo que permite pensar en estrategias en favor del desempeño de estos profesionales y el restablecimiento de los pacientes pediátricos quemados.
Morfometri dan Daya Tampung Beban Pencemaran Danau Pondok Lapan, Kabupaten Langkat Provinsi Sumatera Utara
Authors: Muhtadi Ahmad , Yunasfi Yunasfi , Ma'rufi M. , Rizki A.
Published: October 2019

Morphometry and Pollution Load Capacity of Lake Pondok Lapan in Langkat Regency, North Sumatra. Morphometry is necessary to know the physical characteristics of a lake and how much the ability of the lake to receive pollutant loads. Determination of water quality status and pollution load capacity of lake water is very important to do with the utilization of lake by the community for cultivation activity of floating net cage (KJA). This study aimed to determine the characteristics of morphometry and bathymetry of the lake, determine the status of water quality and the capacity of lake pollution load. The study was conducted in January–March 2015. Mapping was done by making a path of 100 trajectories which was then processed with ArcView. The observation station for water quality consisted of 4 stations. The status of water quality was determined by the Pollution and Storage Index method based on PerMen LH. No. 115 of 2003. The capacity of lake pollution loud refers to PerMen LH. 28 of 2009. The results showed that Lake Pondok Lapan area reached 63,472.78 m2 (6.35 ha) with a maximum depth of 4.15 m. This lake is classified as a closed water, aerobic, with a residence time of 11–12 days. The depth of compensation is at a depth of 2.61–2.85 m. The water discharge coming out of the lake ranges 12,963.45–14,111.71 m³ per day. The status of water quality of Lake Pondok Lapan is categorized as uncontaminated with score 0 for the Storet method and 0.46–0.86 for Pollution Index method. Lake pollution load capacity is of 1.98 kg of phosphorus per year.
Dinamika Proses Sedimentasi di Perairan Muara Sungai Riko, Teluk Balikpapan
Authors: Soeyanto Endro , Arifiyana Arifiyana
Published: October 2019

Dynamics of Sedimentation Process at Riko River Estuary, Balikpapan Bay. Development of the marine facilities (i.e. port, workshops, laboratories, etc)  for Indonesian Research Vessels and National Center for Marine Research in the proposed National Science Technopark (NSTP) Maritime Region at District of Penajam Paser Utara, East Kalimantan Province, needs to understanding the dynamic of waters physical environment. Due to the NSTP-Maritime region located at Riko River as part of Balikpapan Bay waters, it needs an ocean interaction study between open sea (Balikpapan Bay) and Riko River waters. This study used a 2D-Hydrodynamic Model  for  Riko River and Balikpapan Bay waters and adjacent sea. The model simulated the hydrodynamic conditions on the waters and   furthermore predicted   the mud transport in  September - November 2016 using the river flow and total suspended sediment data collected in November 2016. The model results showed that the average of sediment load movement due to the dynamic of waters at the estuary is   ± 4,25 x10-3 kg per second or ± 367,7 kg per day. This preliminary study hopefully  can explain the shallowing  processes in mouth of Riko River.
Struktur Komunitas Moluska di Padang Lamun Perairan Kepulauan Padaido dan Aimando Kabupaten Biak Numfor, Papua
Authors: Aji Ludi Parwadani , Widyastuti Andriani , Capriati Agustin
Published: October 2019

Community Structure of Mollusca in Seagrass Beds Padaido and Aimando Islands Biak Numfor Regency, Papua. Mollusca is one of marine biota which is commonly found in seagrass beds and largely utilized by inhabitants in Biak. However, information about the diversity and abundance of mollusca in Padaido Aimando Islands, Biak Papua is still limited. The research about mollusca composition in the seagrass beds of Padaido Aimando Islands, Biak was conducted in April – October 2014. Sampling method using quadrat transect from the beach toward the sea at 15 stations. Mollusca samples preserved in alcohol 40%, then it was cleaned and identified in the laboratory. In this research was found 239 species of mollusca, which consists of 177 species from Gastropods and 62 species from Bivalves. Mollusks gastropod that have high distribution is Monetaria annulus, Conomurex luhuanus dan Canarium urceus, while of class Bivalvia is Anadara antiquata. The highest value index of species diversity (H) is found at Station 7 (3.951) and the lowest at Station 14 (3.077). Value index of species richness (d) ranged between 9.041 and 10.883 and evenness index value (J) ranged between 0.768 and 0.99. While the dominancy index ranged from 0.020 to 0.092. Based on similarity index, Station 3 has a high similarity with station 4. This research provides valuable information on the diversity and abundance of mollusca which can be useful for decision making aimed at the management of mollusca resource in Biak.
LA CUESTIÓN AMBIENTAL EN EL CAPITALISMO DE LA PERSPECTIVA DE MOVIMIENTOS SOCIALES
A QUESTÃO AMBIENTAL NO CAPITALISMO DESDE A PERSPECTIVA DOS MOVIMENTOS SOCIAIS
THE ENVIRONMENTAL QUESTION ON CAPITALISM FROM THE SOCIAL MOVEMENTS PERSPECTIVE
Authors: Schlesener Anita Helena , Souza Maria Antonia de , Rosa Maria Arlete
Published: October 2019

El artículo trata del dilema que vive la humanidad de cómo preservar el sistema ecológico y la biodiversidad para la sostenibilidad frente a la constante depredación del capital y la forma de vida capitalista que se nos presenta como el Ideal. ¿Cuál es la tarea de la educación en esta realidad concreta? Las reflexiones de naturaleza bibliográfica y documental consideran que los movimientos sociales son portadores de referencias analíticas para comprender el aprendizaje generado en contradicciones, luchas y participación social, teniendo el Movimiento de Trabajadores Sin Tierra (MST) y la Via Campesina como protagonistas de prácticas sociales colectivas que contrastan críticamente con el modelo capitalista de producción a gran escala conocido como agronegocios. Se basa en el modelo agroecológico, en defensa de la educación crítica y la formación integral del hombre y las nuevas generaciones con miras a una sociedad planetaria justa y sostenible.

O artigo trata do dilema que vive a humanidade de como preservar o sistema ecológico e a biodiversidade para sustentabilidade ante a constante depredação do capital e do estilo de vida capitalista, que nos é apresentado como o Ideal. Qual é a tarefa da educação nesta realidade concreta? As reflexões de natureza bibliográfica e documental consideram que os movimentos sociais são portadores de referências analíticas para se compreender o aprendizado gerado nas contradições, nas lutas e na participação social, tendo o Movimento dos Trabalhadores Rurais Sem Terra (MST) e a Via Campesina como protagonistas de práticas sociais coletivas que se contrapõem de forma crítica ao modelo capitalista de produção em larga escala, conhecido como agronegócio. Fundamenta-se no modelo agroecológico, na defesa da educação crítica e formação integral do homem e das novas gerações com vistas a uma sociedade planetária justa e sustentável.

The article deals with the dilemma that mankind lives of how preserving the ecological system and biodiversity for sustainability in the face of the constant depredation of capital and the capitalist way of life presented to us as the Ideal. What is the task of education in this concrete reality? Reflections of bibliographical and documentary nature consider that social movements are bearers of analytical references to understand the learning generated in contradictions, struggles and social participation, having the Landless Workers Movement (MST) and Via Campesina as protagonists of collective social practices that contrast critically to the large-scale capitalist model of production known as agribusiness. It is based on the agroecological model, in defense of critical education and integral formation of man and the new generations aiming a just and sustainable planetary society.
Automated calculation of the RD parameter in euglycemic insulinmic clamp
Authors: Dreval A. V. , Suzdalnitsky R. S. , Dreval T. P. , Vladimirov P. V. , Bairamkulov Kh. D. , Titova G. V. , Grebenev D. E. , Anykina N. V.
Published: October 2019

The authors proposed a new analytical approach to a search for the RD parameter in euglycemic insulinemic clamp which imparts a rate to glucose infusion. Two diabetic patients were investigated (RD parameter in the first case was determined by intuition, and in the second case on the basis of mathematical iterative formulas). The analytical approach permitted a two-fold reduction of the time of clamp investigation improving its quality.
Fine needle puncture biopsy and imaging methods of the thyroid gland in the diagnosis of nodular goiter
Authors: Vnotchenko S. L. , Okeanova T. A. , Bronshtein M. E. , Nefedov S. B. , Fedoseeva G. I.
Published: October 2019

A retrospective analysis of the results of puncture thyroid biopsy is presented in 256 patients operated on for nodular goiter. Cytological data coincided with histological in 84.8% of cases. Coincidences were most frequent with (multiple) nodular colloid goiter and thyroid cysts (95.7 = 100%) and the least with a single adenoma (65.4%) of predominantly follicular structure. In thyroid cancer, the data correlated in 75% of cases. The presence of cystic changes in the adenoma made the study less informative. The results of an ultrasound examination of the thyroid gland coincided with operational data in 87.5% of patients with (multiple) nodular goiter and in 86.1% of patients with adenomas. Ultrasonography as a method of imaging the thyroid gland is preferable to scintigraphy (scanning) and is the optimal complement to the thyroid puncture biopsy.
The use of glycemic indices in the diet therapy of diabetes mellitus (lecture)
Authors: Kasatkina E. P. , Odud E. A.
Published: October 2019

Diabetes mellitus (DM) is one of the endocrine-metabolic diseases in which diet therapy is one of the main methods of treatment. At present, around the world, the most appropriate in the complex therapy of this disease is recognized as a physiological diet, which contains the number of calories necessary for a full life of the patient with a balanced ratio of proteins, fats and carbohydrates.
Study of absorption of subcutaneously injected short-acting insulin in diabeties
Authors: Nakamura T. , Sekino K. , Kasai F. , Ishii M. , Kudoo K. , Imamura K. , Kikuchi H. , Takebe K.
Published: October 2019

In patients with diabetes mellitus (DM), it is necessary to constantly monitor the level of glucose in the blood to prevent the onset and development of complications of the disease. When conducting insulin therapy in patients with diabetes, despite the introduction of the same amount of insulin, changes in blood glucose in many patients have significant differences. An abnormality in the absorption of insulin from subcutaneous adipose tissue is indicated as one of the reasons. So far, basic research on insulin absorption has been mostly done in healthy people. In this work, we studied the absorption of human short-acting insulin (simple, short insulin), administered subcutaneously, in patients with diabetes, measuring the insulin content in serum.
Interaction of antibodies from the sera of autoimmune patients
thyroidopathies with isolated diffuse cells toxic euthyroid nodular goiter.
Authors: Krainova S. I. , Kandror V. I.
Published: October 2019

Blood sera of 46 patients with diffuse toxic goiter (DTG) and of 48 ones with Hashimotos thyroiditis (HT) were tested for antibodiescomplement-mediated cytotoxicity carriers (ACMMC). ACMCC targets were isolated DTG cells and cells of euthyroid nodular goiter (ENG) perinodular tissue. Antimicrosomal antibodies were assayed in the sera by indirect immunofluorescence and antibodies to all thyrocyte surface antigens isolated from both tissue samples were determined by solid-phase enzyme immunoassay. When DTG cells were targets, DTG patients' sera detected ACMCC in 36 % of cases and HT patients sera in 73% of cases (p0.001).

In ENG cells the sera of patients of both groups detected ACMCC equally frequently (in more than 70% of cases). Of the 27 DTG patients sera tested with both tissues app. roximately a half detected ACMCC in only ENG tissue. There was no difference in HT patients sera effects on ACMCC detection in both tissue samples. This has brought the authors to a conclusion about DTG cells deficiency for ACMCC mediating antigens. Moreover, DTG cells bound much less antibodies from sera of patients with autoimmune thyropathies, than ENG cells (p0.001), this confirming a deficiency of surface antigen on DTG cells. No correlation between the presence in the sera of antimicrosomal cells and of ACMCC was detected. A conclusion has been made about heterogeneity of antimicrosomal antibody population and about the presence of ACMCC in blood sera of patients with autoimmune thyropathies, these antibodies not belonging to antimicrosomal ones. ACMCC also may be heterogenous and differ in DTG and HT patients.
Pituitary-adrenocortical system
with experimental hereditary hypertension
Authors: Naumenko E. V.
Published: October 2019

An experimental study of hypertension is the main way to discover the mechanisms of formation, flow patterns and the search for ways to prevent one of the most common human diseases. The most interesting in this aspect are genetic models [19], since heredity plays a significant role in the pathogenesis of hypertension. In most of these models created on rats by their long-term selection for high blood pressure (BP), its increase occurs spontaneously, that is, almost independently of environmental influences, and is determined mainly by the animals genotype (lines GH, LH, MSN and SHR ) In such rats, hypertension is irreversible; its formation is inevitable for all individuals without exception.
Endocrinal function of the pancreas in rats with diabetes mellitus and specific features of this function adaptation to hypoxia
Authors: Kolesnik Yu. M. , Abramov A. V.
Published: October 2019

The present research was aimed at examination of the endocrinal system of the pancreas in diabetes mellitus, adaptation to hypoxia, and their combination in rats in order to elucidate the relationships between A, B, and D cells under various conditions. The status of Langerhans islet cells was assessed by radioimmunoassay, measurements of blood hormones, and by immunologic method for their quantitative detection in cells. Development of the early stages of diabetes mellitus was found to be associated with a marked restructuring of the total endocrinal system of the gland. Reduction of insulin level was parallelled by a compensatory activation of glucagon- and somatostatin-producing systems. Islet cell changes under such conditions were characterized by sexspecific features. Adaptation to hypoxia was found to have a favorable effect on the course of diabetes mellitus in rats, this manifesting by an increase of blood and В cell insulin levels, by inhibition of islet destruction process, and by reduced production of glucagon and somatostatin.
Социальное обслуживание пожилых: реализация Федерального закона № 442 и дальнейшие перспективы
Authors: Григорьева Ирина Андреевна , Сизова Ирина Леонидовна , Москвина Анастасия Юрьевна
Published: October 2019

В статье обсуждаются современное состояние и перспективы развития социального обслуживания пожилых в России после вступления в действие в 2015 г. Федерального закона № 442 от 22 декабря 2013 г. Основное внимание уделено противоречивому характеру реформирования и его последствиям. Децентрализация управления и передача полномочий по реализации ФЗ-442 в регионы связаны с разным пониманием задач, поставленных государством перед стейкхолдерами. В результате реформирования меняется логика социального обслуживания населения: клиенты становятся потребителями и покупателями, государственные социальные службы теряют монополию и вынужденно взаимодействуют с остальными поставщиками социальных услуг в конкурентной рыночной среде. Из-за высокой степени самостоятельности регионов в толковании положений федерального закона оценить степень изменений и улучшение качества социального обслуживания трудно. Авторы анализируют итоги эмпирического качественного исследования процесса реформирования социального обслуживания в одном из центральных регионов России (Нижнем Новгороде). На основе анализа транскриптов полустандартизированных интервью с участниками реализации ФЗ-442 выделены и обсуждены наиболее значимые темы, демонстрирующие специфику и особенности происходящих изменений, показывающие ближайшие перспективы в его развитии.

Результаты исследования показывают ограничение как свободы выбора клиентов, так и формирования из них активных потребителей социальных услуг, погоню за массовостью услуг и количеством потребителей, повышение нормативов обслуживания, сопротивление необходимости конкуренции и желание сохранить сложившееся положение вещей. Авторы заключают, что адресность помощи и взаимность как важнейшие современные принципы социальной работы в России не реализуются. Необходимо активизировать ресурсы клиентов, сформировать систему взаимодействия государства, коммерческого и общественного секторов для обновления социального обслуживания пожилых.

Благодарность. Статья подготовлена в рамках проекта РНФ 19-18-00246 «Вызовы трансформации социального государства в России: институциональные изменения, социальное инвестирование, цифровизация социальных услуг».
Когда опасности становятся рутиной: конструктивистский подход в исследовании профессиональных рисков (на примере работников угольных предприятий г. Новокузнецка)
Authors: Соломин Максим Сергеевич
Published: October 2019

Статья посвящена развитию конструктивистского подхода к изучению профессионального риска. Автор предлагает концептуальную схему анализа, которая основывается на теоретических предпосылках социологии риска, таких как неизбежность риска, его воспроизводимость в ходе интеракций, социальная обусловленность. Ядром этой схемы является положение, согласно которому профессиональный риск неразрывно связан с субъектом, принимающим решение. Отдельное внимание уделяется влиянию «жизненного мира» профессии на формирование представлений субъекта о рисках.

Автор показывает возможный вклад конструктивистского подхода в решение такой социологической проблемы, как расхождение реального поведения работников с нормативно закрепленными предписаниями техники безопасности.

Эмпирическую базу исследования составляют 12 полуструктурированных интервью с работниками угольных предприятий г. Новокузнецка. Было выявлено, что действия работников обусловлены представлениями о допустимых издержках и возможных выгодах. Эти представления, формируясь в условиях, когда профессиональная среда представляет собой набор рутинизированных опасностей, в определенных обстоятельствах смещаются в сторону возможной выгоды. В результате те формы поведения, которые с позиции реалистского подхода к анализу риска считаются нарушением формальных норм безопасности, могут быть устойчивыми действиями, направленными на получение выгоды, необязательно материальной.