bluuebunny/crossref_metadata_2025 huggingface dataset:
Implant bone screw characteristics of a printed PLA-based material
Authors: Dvorak Karel
Published: August 2024

ASTM F543 specifies the testing characteristics of bone screws. It consists of 4 phases of separate tests, 3 of which are carried out according to a standard procedure using strictly prescribed material. Testing according to this standard is part of the standardization and certification process for bone implants. The PUR 30 PCF material simulates bone for the respective test. The standardized testing results are primarily used to compare the characteristics of the implants tested. At the same time, the information obtained is essential for the verification of real bone screw implantation procedures. In addition to the design of implants and fixation elements, the purpose of using the results of testing using a surrogate material may be, for example, to teach implantation procedures or to train and simulate real implantation procedures, especially in complicated cases. The advantage of using bodies made of poly lactic acid (PLA) material, prepared by additive technology, lies mainly in the possibility of realizing free shapes corresponding to the shapes of natural bone. The present content introduces the problem of defining the structure of test bodies made of additively prepared PLA material and presents the results of comparative testing with PUR 30 PCF material.
Surface plasmon polariton–enhanced upconversion luminescence for biosensing applications
Authors: Le Duc , Kreivi Marjut , Aikio Sanna , Heinilehto Noora , Sipola Teemu , Petäjä Jarno , Guo Tian-Long , Roussey Matthieu , Hiltunen Jussi
Published: August 2024

Upconversion luminescence (UCL) has great potential for highly sensitive biosensing due to its unique wavelength shift properties. The main limitation of UCL is its low quantum efficiency, which is typically compensated using low-noise detectors and high-intensity excitation. In this work, we demonstrate surface plasmon polariton (SPP)-enhanced UCL for biosensing applications. SPPs are excited by using a gold grating. The gold grating is optimized to match the SPP resonance with the absorption wavelength of upconverting nanoparticles (UCNPs). Functionalized UCNPs conjugated with antibodies are immobilized on the surface of the fabricated gold grating. We achieve an UCL enhancement up to 65 times at low excitation power density. This enhancement results from the increase in the absorption cross section of UCNPs caused by the SPP coupling on the grating surface. Computationally, we investigated a slight quenching effect in the emission process with UCNPs near gold surfaces. The experimental observations were in good agreement with the simulation results. The work enables UCL-based assays with reduced excitation intensity that are needed, for example, in scanning-free imaging.
A positive scratch collapse test in anterior cutaneous nerve entrapment syndrome indicates its neuropathic character
Authors: Jacobs Monica L. Y. E. , ten Have Tom , Schaap Lotte , Scheltinga Marc R. M. , Roumen Rudi M. H.
Published: August 2024

Objectives

Chronic abdominal pain is occasionally caused by an abdominal wall entity such as anterior cutaneous nerve entrapment syndrome (ACNES). This syndrome is thought to occur due to intercostal nerve branches (T7–12) that are entrapped in the rectus abdominis muscles. The diagnosis is largely based on subjective clues in patient history and physical examination. A test referred to as the scratch collapse test (SCT) is used as an additional diagnostic tool in peripheral nerve entrapment syndromes such as the carpal tunnel syndrome. The aim of the present study is to investigate whether an SCT was positive in patients with suspected ACNES. If so, this finding may support its hypothesized neuropathic character.

Methods

A prospective, case–control study was performed among patients with ACNES (n = 20) and two control groups without ACNES (acute intra-abdominal pathology n = 20; healthy n = 20), all were consecutively included. ACNES was diagnosed based on previously published criteria. The SCT test was executed at the painful abdominal area in both patient groups and at a corresponding area in healthy controls. Predictive values, sensitivity, and specificity were calculated. Videos of tests were evaluated by blinded observers.

Results

SCT was judged positive in 19 of 20 ACNES patients but not in any of the 40 controls. A 95% sensitivity (confidence interval [CI]: 75–99) and optimal specificity (100%; CI: 83–100) were calculated.

Conclusions

The positive SCT supports the hypothesis that ACNES is an entrapment neuropathy. A positive SCT should be considered a major diagnostic criterion for ACNES.
Ford Madox Ford’s “Cold Pastoral”: The Last Post
Authors: Reichmann Angelika
Published: August 2024

The essay discusses the last volume of Ford Madox Ford’s tetralogy Parade’s End (1924-28). As Andrew Hampson and Robert Purssell highlight, whether The Last Post is an integral part of the tetralogy has been heavily debated since Graham Greene decided to publish the 1963 edition of the ‘Tietjens Saga’ as a trilogy. As they go on to explain, a major charge against the volume is “tying up too neatly various loose ends” (2013). Indeed, The Last Post seems to call for an interpretation in the pastoral tradition, which suggests that Ford’s novel—especially in comparison with Rebecca West’s The Return of the Soldier (1918)—ends in an idyll even if it is not free from certain ironies inherent in pastoral literature, as Seamus O’Malley (2007) maintains. In my view, on closer scrutiny, these ironies fundamentally undermine the “too neat” ending of the tetralogy. Haunted by the aftereffects of war and the ghosts of Mark’s, Christopher’s and Valentine’s former selves, dissolving identities not only by decentering but also by doubling, this apparent idyll far too often offers glimpses of its own Gothic alter ego, a narrative of madness, imprisonment and disintegration. Yet, as consistent readings of the novel in the pastoral mode imply, the Gothic double never fully takes over but, in my interpretation, subverts the superficial idyll of The Last Post, and with that, fully optimistic interpretations of the entire tetralogy.
Anita Rákóczy, Mariko Hori Tanaka, and Nicholas E. Johnson, eds. Influencing Beckett / Beckett Influencing
Authors: Kurdi Mária
Published: August 2024

Although Beckett is a highly acclaimed author in Hungary whose works are available in translation, and his plays have been staged several times since the Hungarian premiere of Waiting for Godot in 1965, books written about him by Hungarian authors were unduly delayed. This strange, long-standing situation became luckily altered by the publication of the essay collection under review here in 2020. The essays were originally papers given at the Samuel Beckett Working Group meeting held at Károli Gáspár University of the Reformed Church in Budapest, organized by the three scholars who edited the collection. The preface to the book is written by renowned Beckett scholar Linda Ben-Zvi, also one of the organizers as representative of IFTR, the International Federation for Theatre Research, “the largest theatre organization in the world.” The Beckett Working Group of the organization had its first meeting in Tel Aviv in 1996, and in 2017 it was hosted by Károli Gáspár University of Budapest. From the start, Ben-Zvi emphasizes, discussions have been enlivened by the diverse cultural experiences of the international mix of group members, ranging from PhD students to professors (9). In accordance, the authors of the present essay collection are from several countries, including Hungary.
Space and Theatre
Authors: Carlson Marvin
Published: August 2024

Theatre as an artistic and cultural activity has been the subject of academic speculation ever since the Greeks, but it was not until the beginning of the nineteenth century that European and American scholars institutionalized a field of theatre studies. A significant part of this new field’s self-definition involved a clear splitting away from traditional literary studies, within which theatre had previously had its academic home. The entire Western tradition, from the Greeks onward, considered the drama primarily as a branch of literature—the other basic divisions being the epic and the lyric. Traditionally theatre scholarship was based upon the literary text (Artistotle’s indifference to spectacle is an early and notorious example of this bias) and the actual process of the physical realization of this text, while not entirely ignored, was a matter of considerably less interest.
Gabriella Vöő: From the East Looking West: British and Irish Culture and National Self-Definition in Interwar Hungary. Pécs: University of Pécs, Institute of English Studies, 2011. 116 pages.
Authors: Kurdi Mária
Published: August 2024

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Heterotopic and Funerary Spaces: Martin McDonagh’s A Skull in Connemara
Authors: Jordan Eamonn
Published: August 2024

Traditionally, the west of Ireland has been framed more often than not as a potential pastoral space, one of refuge, sanctuary and belonging, as well as a place where individuals can reflect, mature and heal. Pastoral spaces are also ones of grief, where death is accommodated and eulogized (See Gifford 7-8). Pastoral is often aligned with an utopian trope. Michel Foucault’s ideas on heterotopic spaces offer a very apposite addition to discussions on the pastoral and they also link in with the notion of funerary practices, allowing one to interlink the transcendent, and its opposite, the sanctified and the de-sanctified, the notionally sociologically real and the imaginary. Writing in 1967, Foucault speaks of the fact that “contemporary space is perhaps still not entirely de-sanctified (apparently unlike time, it would seem, which was detached from the sacred in the nineteenth century)” and that oppositions between “family space and social space, between cultural space and useful space, between the space of leisure and that of work” . . . remain inviolable,” as that inviolability is still “nurtured by the hidden presence of the sacred” (23). While pastoral spaces notionally can be some of the better examples of idyllic sanctified spaces, that sense of “inviolable” divisions seems to no longer stand in relation to McDonagh, as he is both evoking but also disputing that “hidden sense of the sacred” in A Skull in Connemara (1997).
(Re)Politicized and (Over)Sexualized―Wild(e) Treatments on Twenty-First-Century Viennese Stages
Authors: Mayer Sandra
Published: August 2024

With Oscar Wilde’s reinvention as “Our Contemporary” and conveniently adaptable icon of postmodern culture in the last two decades, the author’s popular society comedies have evolved into an inexhaustible mine of multiple signification, inviting a broad range of interpretive disambiguation strategies. Inevitably, the diverse textual and dramaturgical schemes of adapting the plays for the twenty-first-century theatre market chiefly rely on what John Stokes has diagnosed as a “quality endemic to the plays: an interplay between performance, audience, and outside world”. Thereby engaging their biographical dimension in a “tangled web” of politics, popular culture, and postmodern aesthetics, contemporary Viennese theatrical readings of Wilde ultimately may be regarded as both reflecting and securing the playwright’s canonical survival.
"There's no cure for the Internet" - Surveillance, Spectatorship, and Sanctuary in Black Mirror
Authors: Novák Zsófia
Published: August 2024

The British-American anthology series Black Mirror (2011-2019) constructs delicately balanced worlds that are “just realistic enough to get under the viewer’s skin, yet just extreme enough to grab attention and not let go until [the] bleak resolution” (33). The episodes that I will examine here may be read as examples of surveillance capitalism’s modus operandi. “Hated in the Nation” and “Fifteen Million Merits” present over-technologized societies characterized by a complete lack of privacy, eliminating both sanctuary and exit—which, as Zuboff also contends, is closely correlated with the individual’s lack of agency in- or outside the (social) hive (444). Although the selected episodes are characterized by substantial differences in tone, setting, plot, and aesthetic and psychological strategies, surveillance and spectatorship— complicating boundaries between externality and internality—have central functions in both. Concerned both with the characters’ experience and with the audience’s position(ality) and identification processes in the act of viewing, this essay analyses the mechanics of the filmic text in the episodes, looking at how it problematizes the central issues of spectatorship, surveillance, and (the lack of) sanctuary.
Beyond Inca roads: the Redes Andinas project explores complex palimpsests of Andean road networks
Authors: Saintenoy Thibault
Published: August 2024

The Redes Andinas (Andean Networks) project assesses the complexity of ancient road networks in the archaeological record in the Andes, beyond the Inca roads system. A multiscale methodological approach allows us to characterise the transformation and resilience of the road networks over the past millennium, in the context of the 18°South parallel's vertical transect.
The NUDGE Framework: Application to Address Behavioral Barriers to Antiretroviral Therapy in Adolescents Living With HIV in Eswatini
Authors: Ahmed Charisse V. , Dlamini Ayanda , Mbuyisa Majaha , Simelane Mthobisi , Gallagher Darby , Golos Aleksandra , Donworth Gregory , Dubner Jacob , McLain Lindsey , Lowenthal Elizabeth D. , Rice Bridgette M. , Brooks Merrian J. , Buttenheim Alison M.
Published: August 2024

Behavioral economics offers a unique opportunity to understand the social, cognitive, and psychological nuances that may influence health behavior. The purpose of this article is to demonstrate the application of NUDGE, a novel behavioral economics and design thinking framework, to address barriers to antiretroviral therapy adherence among adolescents living with HIV in eSwatini. NUDGE comprises five steps: (1) Narrow the focus to a specific target behavior, (2) Understand the context of the behavior through inquiry, (3) Discover behavioral insights related to the target behavior, (4) Generate intervention design features to address behavioral barriers to the target behavior, and (5) Evaluate the design features through iterative pilot testing. This article demonstrates the application of the Discover and Generate steps using qualitative data. In showing the utility of the NUDGE framework, we provide a practical tool for creating interventions informed by behavioral insights.
Projetos de trabalho na universidade
Authors: Juchum Maristela
Published: August 2024

Uma das dificuldades que os alunos encontram quando ingressam no ensino superior envolve escrita e discurso acadêmico. Neste trabalho, é analisada uma prática pedagógica que toma os projetos de trabalho como fio condutor do planejamento para o ensino da leitura e da escrita na universidade. Trata-se de um recorte da pesquisa-ação que originou a tese de doutorado intitulada Letramentos acadêmicos: projetos de trabalho na universidade, defendida no primeiro semestre de 2016, na UFRGS. Objetiva-se, neste trabalho, analisar se a pedagogia de projetos possibilita tratar os alunos como colaboradores no desenvolvimento dos letramentos acadêmicos. A geração de dados foi realizada com uma turma de alunos matriculados na disciplina de Leitura e Produção de Texto I, do Centro Universitário UNIVATES, durante o semestre B/2013. Neste estudo, serão analisados excertos de diários de campo e de entrevistas que narram as interações entre os participantes dos projetos enquanto liam e produziam textos, a fim de construírem conhecimento acadêmico sobre o tema do projeto. Enquanto dados conclusivos, evidencia-se a importância dos projetos, como possibilidade de os estudantes se engajarem nas práticas de letramento acadêmico valendo-se especialmente do diálogo, do fazer juntos, do negociar as decisões, impondo novos modos de fazer e de dizer na universidade.
A identidade de cotistas e não cotistas em comentários online
Authors: Rohling Nívea , Machna de Mendonça Ester
Published: August 2024

O presente estudo teve por objetivo investigar as valorações sobre a identidade de cotistas e não cotistas, materializadas em enunciados do gênero comentários online. Para isso, foram analisados comentários em respostas a uma publicação da Universidade Federal do Paraná (UFPR), em sua página oficial do Facebook, inserida no contexto de divulgação dos resultados da primeira fase do vestibular da UFPR de 2015. A discussão sobre identidade está ancorada em Hall (2006), Silva (2014) e Woodward (2014), estudiosos dos Estudos Culturais. Além disso, a compreensão do comentário online como gênero está baseado nas teorizações do Círculo de Bakhtin (BAKHTIN, 2011 [1952]; BAKHTIN; VOLOCHÍNOV, 2010 [1929]; VOLOCHÍNOV, 2013[1930]) e em Alves Filho e Santos (2013). A análise dos comentários explicitou uma série de construções valorativas no tocante à posição identitária de sujeitos cotistas e não cotistas: valorações que desqualificam os cotistas, valorizam os não cotistas e separam (e hierarquizam) esses grupos sempre por meio de oposições binárias.
Ensino de gramática no cenário atual
Authors: Alves Rosana Ferreira
Published: August 2024

Discute-se, por meio de abordagem qualitativa, pautando-se em questões de avaliações discentes, como o ensino de gramática tem sido abordado em sala de aula, e, sobretudo, apresentam-se indicativos que podem colaborar para a melhoria da qualidade didático-pedagógica do trabalho, considerando parâmetros estabelecidos nas três últimas décadas. Para tanto, pautam-se em pesquisas sobre o assunto em Pedagogia e Linguística - Teórica e Aplicada (GERALDI, 1984; NEVES, 1990; PERINI, 1995; TRAVAGLIA, 2007, 2009 e 2010; CABRAL, 2015, dentre outros). As avaliações analisadas evidenciam presença predominante de abordagem normativa (identificação e classificação de categorias gramaticais). Entretanto, para colaborar com a mudança no rumo do ensino de gramática, propõe-se que as atividades de ensino e de aprendizagem devem levar em consideração o predomínio de práticas que envolvam: (i) trabalho com o texto (oral, escrito e de diversos gêneros); (ii) reflexões por meio de análise linguística; e (iii) realização de pesquisas que ultrapassem o âmbito do diagnóstico, de modo a colaborar com o processo de formação continuada dos profissionais.
A influência do “outro” no extremo sul do Brasil
Authors: Marroni Fabiane Villela
Published: August 2024

Mudanças nos valores e costumes da população burguesa europeia, no final do século xix e início do século xx, foram logo assimiladas no Brasil. Uma visão de mundo que se enunciava com marcas de um outro, em um período eufórico, num discurso de modernidade, de mudanças no modo de vida de uma parcela da sociedade. Ideias de progresso e civilização divulgadas pela imprensa e ancoradas em sua Belle Époque. Utilizando como base teórica e metodológica a teoria da semiótica discursiva, este trabalho tem como objetivo um breve estudo exploratório da mídia impressa em Pelotas a partir do final do século xix, para entender o processo de transformação da cidade, que atingiu, também, a imprensa.
Guia de sobrevivência
Authors: Aquino Marceli
Published: August 2024

O presente artigo visa discutir a relevância do desenvolvimento de estratégias comunicativas e socioculturais no ensino e aprendizagem de Português Língua Adicional (doravante PLA) em contexto de imersão. As atividades sugeridas procuram trabalhar língua e cultura de forma integrada, focando especialmente nas necessidades comunicativas de aprendizes multilíngues. Metodologicamente este trabalho baseia-se nos estudos relacionados às estratégias comunicativas, o conceito de autonomia na aprendizagem, além da abordagem intercultural no ensino de línguas. Neste sentido, busca-se descrever as experiências e práticas didáticas no intuito de auxiliar professores no desenvolvimento de atividades e tarefas dinâmicas, onde seja possível ter em conta a necessidade de alunos de diferentes línguas e contextos sociais. Os resultados sugerem que atividades que incentivam o uso de habilidades e estratégias comunicativas requerem dos aprendizes autonomia e responsabilidade em seu processo de aprendizagem, auxiliando, portanto, a superação de desafios na aprendizagem de PLA, além da adaptação cultural.
A estética intersemiótica de Alexandre Orion
Authors: Claudia de Oliveira Ana
Published: August 2024

Tratando os encadeamentos dos enunciados de estados movidos pelos enunciados de transformação, A. J. Greimas estatuiu a narratividade como um universal de todos os tipos de manifestações humanas e elaborou uma gramática narrativa baseada na lógica da junção com os estados de conjunção vs. disjunção, desenvolvendo uma teoria das modalidades do ser e do fazer principalmente voltada aos discursos manipulatórios, da ação dos homens sobre os homens, e aos discursos de regulação das coisas, objetos e dos próprios homens. Apoiado nesse quadro conceitual E. Landowski conceituou a lógica da união em complementariedade à da junção para dar conta das afetações sensíveis, assim como do imponderável dos acidentes imprevisíveis. Em um atuar articulado esse último postulou a homologação entre regimes de interação, risco e sentido que aborda a dinâmica da circulação dos vários procedimentos estruturantes das manifestações de linguagens. Com esses subsídios teórico-metodológicos é que me lanço na análise da problemática da infância na cidade grande nos termos que o paulistano Alexandre Orion, artista intervencionista, propõe em suas obras intersemióticas na cidade de São Paulo. As linguagens em articulação mostram em sua explicitação do funcionamento das várias semióticas convocadas na configuração da obra de Orion como cabe ao homem, ser de linguagem, promover uma outra construção do social mostrando como essa é obra da interação entre os viventes que têm a força de ruptura do status quo.
Storage behaviour and seed longevity of traditional African vegetables: a review
Authors: N'Danikou Sognigbe , Ayenan Mathieu A.T. , Sigalla Jeremiah P. , Shango Abdul J. , Zonneveld Maarten van
Published: August 2024

Effective management of seed collections in genebanks requires knowledge of seed storage behaviour and species-specific longevity under conventional air-dry storage. This knowledge is lacking for traditional African vegetable (TAV) crops compared to cereals and conventional vegetables.
This review aimed to assess the published literature until December 2023. The findings will guide post-harvest seed processing (cleaning and drying), storage (containers, storage parameters), viability monitoring and regeneration intervals, and to identify further research gaps that will inform
data needs from the genebanks conserving TAV seeds. Our findings show that, compared to cereals and legumes, there is limited information available on vegetable crops and more acutely on TAVs. While conventional vegetable seeds benefited from research on their storage behaviour and longevity,
there was significant neglect of TAV crops, which represented only 17% of the studies reviewed. Overall, genebanks involved in TAV germplasm conservation should invest more time and resources to investigate seed physiology and generate data that will inform on the storage behaviour
and longevity of these crops under medium and long-term storage conditions. Such data are important to establish crop-specific knowledge on optimal conditions for high post-harvest seed quality, and for genebanks to plan seed regeneration.
Brgulje u kontekstu hrvatskoglagoljske baštine
Authors: Brkljačić Marko , Šimić Marinka
Published: August 2024

U radu se razrađuje vrijedan i jedinstven kulturni fenomen, običaj brgulja, koji je svjedočanstvo uloge prožimanja hrvatskoglagoljske baštine i lokalne tradicijske kulture. Ponajprije se istražuje etimologija riječi brgulja, odnosno glagola briježiti s potvrdama i značenjima u hrvatskoglagoljskim rukopisima i rječnicima mjesnih govora. Zaključeno je da je brgulja hrvatska narodna riječ praslavenskoga porijekla, deverbativ od glagola brijeći, odnosno korijena -brêg-, suprotno nekim prijašnjim pretpostavkama da je to leksem romanskoga porijekla. Nadalje, navodi se areal pojavljivanja riječi brgulja, odnosno samih narodnih običaja vezanih uz ovaj blagdan, kao i potvrđenost iste riječi u hrvatskoj toponimiji i kod književnika od renesanse do 19. stoljeća. U prilogu se iznose činjenice u vezi s proslavom brgulje u Dalmatinskoj zagori i specifičnostima vezanim uz ovaj običaj u pojedinim mjestima. Ovaj rad prilog je poznavanju glagoljaške tradicije, doprinos poznavanju povijesti hrvatskoga glagoljaštva i njegove povezanosti s praslavenskim, slavenskim i crkvenoslavenskim jezikom.
Rhetoric for Crowds
Authors: Ljubimir Ivan
Published: August 2024

Gustave Le Bon’s eminent work The Crowd is considered as one of the fundamental works in mass psychology. Concurrently, the importance of this work and the impact it had on communication practices has been recently recognized by some of the scholars. While The Crowd primarily places focus on meticulous description of origin and psychological condition of the crowd, this paper suggests that, among others, Le Bon uses psychological discourse to define rhetorical precept that can be used as an agency for eliciting such condition. It is the purpose of this paper to extract and present the guidelines suggested by Le Bon in his work for mass oratory and corroborate it with apposite rhetorical theory in order to lend credibility to this thesis. Through broader treatment of rhetorical modes of pathos (state and language that induces it), orator, oration, and kairos (the right moment), with other hitherto rhetorical and linguistic insights, Le Bon constitutes activation means for evoking the psychological phenomena of the crowd. This paper represents Le Bon’s explicit and implicit rhetorical instructions in The Crowd by constructing the rhetorical model and indicating that his scholarly contribution was rhetorical as was psychological, suggesting consideration of his inclusion in the history of rhetoric and his contribution to the development of contemporary communication practices. This paper represents an interdisciplinary rhetorical model that engages the field of interest of various scientific disciplines, such as linguistics, rhetoric, communicology, public relations, and their subbranches.
Identitet glavnog junaka u romanu Đuka Begović Ivana Kozarca
Authors: Tadić-Šokac Sanja , Brdar Nevena
Published: August 2024

U radu se motri identitet glavnog junaka romana Đuka Begović (dovršen 1908., objavljen u nastavcima u Obzoru 1909., objavljen kao samostalna knjiga 1911. godine) Ivana Kozarca (1885. – 1910.). Analizira se tekući identitet Đuke Begovića koji je vidljiv u njegovim teškim unutarnjim dvojbama, u njegovoj potvrdi vlastitog identiteta, u njegovu odnosu s drugima i u težnji da ostavi trag u svojoj sredini. Nastoji se uspostaviti analitički okvir u kojem se identitet Đuke Begovića nastoji razmatrati kao cilj, svrha, a ne kao unaprijed definirani čimbenik. Njegov se identitet ne razmatra kao nepromjenjiva činjenica, kao esencija, nego kao nešto što napreduje, kao proces. Analizira se njegovo ponašanje u sklopu životnih i sudbinskih zajednica u kojima članovi žive zajedno u neraskidivoj povezanosti te u zajednicama povezanim idejama ili različitim načelima (Siegfried Kracauer). Glavni junak romana gubi moralnu orijentaciju te nije u stanju odrediti što je važno, a što je trivijalno, pa upada u krizu identiteta (Charles Taylor). Đuka Begović ne može donijeti trajne odluke kojih će se pridržavati i tako uvesti stanovite preinake u svoj život. Povremeno nastoji živjeti kao drugi, ali u tome ne pronalazi mir i zadovoljstvo, pa ga njegov krik očaja zbog nemogućnosti potpune slobode dovodi do moralne i ekonomske propasti.
CREB activates the MafA promoter through proximal E-boxes and a CCAAT motif in pancreatic β-cells
Authors: Aida Yuki , Kataoka Kohsuke
Published: August 2024

MafA is a key transcriptional regulator of pancreatic islet β-cell function. Its target genes include those encoding preproinsulin and the glucose transporter Glut2 (Slc2a2); thus, MafA function is essential for glucose-stimulated insulin secretion. Expression levels of MafA are reduced in β-cells of diabetic mouse models and human subjects, suggesting that β-cell dysfunction associated with type 2 diabetes is attributable to the loss of MafA. On the other hand, MafA is transcriptionally upregulated by incretin hormones through activation of CREB and its co-activator CRTC2. β-cell-specific expression of MafA relies on a distal enhancer element. However, the precise mechanism by which CREB-CRTC2 regulates the enhancer and proximal promoter regions of MafA remains unclear. In this report, we analyzed previously published ChIP-seq data and found that CREB and NeuroD1, a β-cell-enriched transactivator, bound to both the promoter and enhancer regions of human MAFA. A series of reporter assays revealed that CREB activated the enhancer through a conserved cAMP-responsive element (CRE) but stimulated MAFA promoter activity even when the putative CRE was deleted. Two E-box elements and a CCAAT motif, which bind NeuroD1 and ubiquitous NF-Y transcription factors, respectively, were necessary for transcriptional activation of the MAFA promoter by CREB. Genome-wide analysis of CREB-bound loci in β-cells revealed that they were enriched with CCAAT motifs. Furthermore, promoter analysis of the Isl1 gene encoding a β-cell-enriched transcription factor revealed that a CRE-like element and two CCAAT motifs, but not the E-box, were necessary for activation by CREB. These results provide clues to elucidate the detailed mechanism by which CREB regulates MafA as well as β-cell-specific genes.
Effects of transmasculine gender-affirming hormone therapy on future reproductive capacity: clinical data, animal models
Authors: Chan-Sui Ruth , Kruger Robin E. , Cho Evelyn , Padmanabhan Vasantha , Moravek Molly B , Shikanov Ariella
Published: August 2024

Testosterone gender affirming hormone therapy (T-GAHT) is frequently used by transgender and gender-diverse individuals assigned female at birth to establish masculinizing characteristics. Although many seek parenthood, particularly as a gestational parent or through surrogate, the current standard guidance of fertility counseling for individuals on testosterone (T) lacks clarity. At this time, individuals are typically recommended to undergo fertility preservation or stop treatment, associating T-therapy with a loss of fertility; however, there is an absence of consistent information regarding the true fertility potential for transgender and gender-diverse adults and adolescents. This review evaluates recent studies that utilize animal models of T-GAHT to relate to findings from clinical studies, with a more specific focus on fertility. Relevant literature based on murine models in post- and pre-pubertal populations has suggested reversibility of the impacts of T-GAHT, alone or following gonadotropin-releasing hormone agonist (GnRHa), on reproduction. These studies reported changes in clitoral area and ovarian morphology including corpora lutea, follicle counts and ovarian weights from T-treated mice. Future studies should aim to determine the impact of the duration of T-treatment and cessation on fertility outcomes, as well as establish animal models that are clinically representative of these outcomes with respect to gender diverse populations.
Desarrollo de puentes aéreos para el desplazamiento seguro de monos en Costa Rica
Authors: Sánchez Porras Ronald
Published: August 2024

Monkey mortality in Costa Rica is due, in most cases, to anthropogenic factors, such as deforestation, forest fragmentation, lack of tree connectivity, and tourism development in most coastal areas. The latter factor has caused the death of at least 450 monkeys per year due to electrocution, as a result of the increase in electrical wiring that has arisen in the different regions with urban development. Faced with this threat, proposals have been developed to avoid the danger, such as the construction of appropriate passage infrastructure for monkeys, the placement of insulated wiring, and the protection of electrical transformers. Using the morphometric measurements of the four species of monkeys native to Costa Rica (Alouatta palliata, Ateles geoffroyi, Saimiri oerstedii, and Cebus imitator), a model of safe and functional aerial passages or bridges for them was designed, the foundations of which are discussed in this article.
Precisiones sobre artículo “Frecuencia elevada de casos de dengue grave durante la epidemia por el linaje II del DENV-2 americano/asiático en el Perú”
Authors: Chavez Mario G. , Guillén Axel , Portugal Walter
Published: August 2024

Sr. Editor,
Hemos leído con atención el artículo de S. Durand y col. publicado recientemente en la revista que dirige, titulado: “Frecuencia elevada de casos de dengue grave durante la epidemia por el linaje II del DENV-2 americano/asiático en el Perú”, el cual se centra en describir las características clínicas de pacientes hospitalizados en la Unidad de Dengue del Hospital de Iquitos en febrero del 2011 (1).
Granulomatosis con poliangitis y síndrome de Kartagener
Authors: Paredes Mayra , Hidalgo Jimena
Published: August 2024

Se presenta el caso de una mujer de 42 años con historia de 1 año de rinosinusitis crónica, parálisis facial izquierda, hipoacusia neurosensorial bilateral y escleritis necrotizante bilateral. En el laboratorio se encontró la proteína C reactiva elevada y anti-proteinasa3 positiva. En la tomografía se observaron bronquiectasias varicosas y quísticas en ambos pulmones y situs inversus totalis. Se concluyó que el cuadro clínico era compatible con granulomatosis con poliangitis y Síndrome de Kartagener. La paciente recibió tratamiento inmunosupresor con rituximab y corticoides a altas dosis. La evolución de la paciente fue parcialmente favorable debido a que presentaba daño orgánico irreversible al momento del diagnóstico.
The experience of solving problems of spiritual and moral personal development in Pechora region when it was part of Estonia in the 1920‒40s
Authors: Borisov Boris
Published: August 2024

This article is devoted to the experience of solving the problems of spiritual and moral education of the individual, which were formulated by representatives of the clergy and the teaching community during the Congress of teachers of the secondary theological school of the Pskov province, held in Pskov on May 2, 1917. The participants of the congress agreed that the important task of teaching the Law of God is not set at the proper level, but is built mainly on formal grounds that cannot serve the development of religious feeling in children. At the same time, despite these shortcomings, the participants of the congress rightly noted that there is no alternative to religious and moral education and upbringing in secondary schools, but at the same time it will be necessary to build a fundamentally new school, and in exceptional conditions of distrust of religion. Expressing the hope that a whole system of new schools would arise in the renewed Russia – from the lowest to the highest, the participants of the congress believed that the new school would contribute to the most complete culture
Die Steigerung der Effektivitiit des Informationssystems in der Landwirtschaft der Republik
Authors: Zinkevičienė Julija
Published: August 2024

In der gegenwärtigen Phase nahm das Interesse für die Steigerung der Effektivität der Informationssysteme besonders zu. In diesem Artikel wird die Analyse und Übersicht der Literatur zu diesem Thema sowie die möglichen Wege zur Steigerung der Effektivität im konkreten Informationssystem der Landwirtschaft der Republik behandelt, wobei besondere Aufmerksamkeit den methodischen und organisatorischen Aufgaben gewidmet wird.
Die Analyse der Forschungen zeigte, dass das gegenwärtige Informationssystem als mittelmäßig auszuweisen ist. Als Hauptwege zur Steigerung der Effektivität sind folgende Momente zu erwähnen:

die Verkürzung der Zeit der Informationsübergabe;
der Einsatz neuer Informationsformen bei der Exploitation der Datenbasis;
ständige Forschung des Bedarfs an Information.
The analysis of the contribution of Lithuania SSR library, bibliography and information scientists to the main stream of union prafile periodical press publications
Authors: Motiekienė Vilija , Stirpeikaitė Olga
Published: August 2024

Research work has become more intensive in recent years in the field of bibliography, library, and information sciences. A greater number of research works analyzing different issues of these sciences are being published.
The present paper addresses one structural aspect of the problem concerning the contribution of Lithuanian bibliography, library, and information scientists to the development of science in the USSR. The paper analyzes the contribution of articles by Lithuanian SSR authors published in the union's profile periodical press.
Several research works, analyzing the contribution of countries, scientific groups, or scientists to the development of science, have been published in the Soviet Union and abroad.
An index that helps address the tasks formulated in the article has been created using some of the statements provided in these works.
Scientific libraries in the classification of the state libraries
Authors: Čepanauskas Algimantas
Published: August 2024

Typology and classification of libraries is the most actual problem in library science. A great number of specialists have made attempts to solve it; however, the problem remains unresolved. The article discusses the issues of special terminology related to library differentiation.
The author focuses on new tendencies in the development of the state library system and the fact that modern library science requires a revision of existing classifications of libraries. The classification proposed by the author is based on the social functions of libraries.
The proposed classification allows for outlining the role of scientific libraries within the library system of the USSR.
XVIII a. Žečpospolitos seimų dokumentai Lietuvos MA CB Senų retų spaudinių ir kartografinių leidinių skyriaus Lituanikos fonde
Authors: Medišauskienė Zita
Published: August 2024

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Violation of γ in Brans–Dicke Gravity
Authors: Nguyen H.K. , Chauvineau B.
Published: August 2024

The Brans Class I solution in Brans–Dicke gravity is a staple in the study of gravitational theories beyond General Relativity. Discovered in 1961, it describes the exterior vacuum of a spherical Brans–Dicke star and is characterized by two adjustable parameters. Surprisingly, the relationship between these parameters and the properties of the star has not been rigorously established. In this article, we bridge this gap by deriving the complete exterior solution of Brans Class I, expressed in terms of the total energy and total pressure of the spherisymmetric gravity source. The solution allows for the exact derivation of all post-Newtonian parameters in Brans–Dicke gravity for far field regions of a spherical source. Particularly for the γ parameter, instead of the conventional result γPPN =(ω+1)/(ω+2), we obtain the analytic expression γexact =(ω+1+(ω+2) Θ)/(ω+2+(ω+1) Θ), where Θ is the ratio of the total pressure P*‖+ 2P*⊥ and total energy E* contained within the mass source. Our non-perturbative γ formula is valid for all field strengths and types of matter comprising the mass source. Consequently, observational constraints on γ thus set joint bounds on ω and Θ, with the latter representing a global characteristic of the mass source. More broadly, our formula highlights the importance of pressure (when Θ ̸ = 0) in spherical Brans–Dicke stars, and potentially in stars within other modified theories of gravitation.
ESKAPE pathogens in pediatric cardiac surgery patients: 5-year microbiological monitoring in a tertiary hospital in Kazakhstan
Authors: Baigenzhin Abay , Bissenova Nelya , Yergaliyeva Aigerim , Marassulov Shukhrat , Tuleubayeva Elmira , Aitysheva Ulzhan
Published: August 2024

Hospital acquired infections greatly affect recovery and survival in pediatric surgical patients. We evaluated prevalence and antimicrobial resistance of ESKAPE pathogens in neonates and infants subjected to cardiac surgery in a tertiary hospital in Central Kazakhstan between 2019 and 2023 (2,278 patients) using routine methods of microbiological detection. ESKAPE pathogens were found in 1,899 out of 2,957 samples (Staphylococcus aureus – 35.3%, Klebsiella pneumoniae – 27.8%, Acinetobacter baumannii – 14.5%, Pseudomonas aeruginosa – 12.4%, Enterobacter sp. – 8.8%, Enterococcus faecium – 1.2%). The total prevalence of ESKAPE increased significantly from 45.1 to 76.9% (P = 0.005) during the study period. The resistance significantly increased in methicillin-resistant S. aureus (MRSA, from 13.7 to 41.9%, P = 0.041) but decreased in carbapenem-resistant P. aeruginosa (from 64.3 to 37.7%, P = 0.037) and carbapenem-resistant A. baumannii (from 48.5 to 19.1%, P = 0.039). Gradual but non-significant changes were shown in third-generation cephalosporin resistant K. pneumoniae (from 63.6 to 45.2%) and carbapenem-resistant K. pneumoniae (from 0 to 8.3%). The relative prevalence of ESKAPE pathogens steadily increased in our pediatric cardiac surgery patients in 2019–2023. The most frequent were S. aureus, K. pneumoniae, and A. baumannii, with dramatically increasing tendencies for MRSA. Our results highlight the necessity for a well-designed infection control strategy and constant microbiological monitoring in pediatric cardiac surgery departments.
Augmented dough rheology, physical and nutritional quality of air fried chips from germinated flour blends of maize and lentil
Authors: Samandeep  , Kaur J. , Kaur K.
Published: August 2024

Blends of germinated maize and germinated lentil (100:0, 85:15, 70:30, 55:45, and 40:60) were utilised for preparation of chips by air frying. Higher contents of protein, ash, total phenols, flavonoids and antioxidant activity were confirmed in germinated flours through analysis of FTIR spectra. Doughs from blends containing higher amounts of germinated lentil flour showed improved viscoelastic behaviour indicating better protein network as compared to maize dough. Significant (P ≤ 0.05) variation was observed in colour and hardness of air fried chips prepared from various blends. The 70:30 blend was found most acceptable based on sensory evaluation. Chips from this formulation were found superior to ungerminated maize chips in terms of protein digestibility and mineral composition.
Strength in weakness: a mystery of hope
Authors: McLaughlin Eric
Published: August 2024

A vocation to serving in severely medically under-resourced settings invariably means facing of our own weakness in realizing that vocation. Christian teaching proclaims that God’s strength in made perfect in weakness, which is both a comfort and a mystery to many in their face of their weaknesses. Without diminishing the mystery, experience demonstrates several ways in which this promise plays out in reality, providing an imaginative stimulus for how it may also be true in ways where it is less understood. Believing such teaching forms part of a necessary theological framework for Christians serving in areas of immense suffering as well as encouraging transparency and vulnerability in regards to their own weaknesses.
ANALISIS KOMUNIKASI INTERPERSONAL ANTARA GURU DAN MURID DI PONDOK PESANTREN QODRATULLAH LANGKAN BANYUASIN DISESUAIKAN DENGAN KITAB TA’LIM MUTA’ALLIM
Authors: Fahmi Muhammad Syahid , MS Ratu Mutialela Caropeboka , Isnawijayani Isnawijayani , Zinaida Rahma Santhi
Published: August 2024

Komunikasi dalam proses belajar mengajar, tidak selalu berjalan mulus, ada proses yang membuat para guru harus sabar dengan tingkah laku murid, hal tersebut bisa dipengaruhi oleh beberapa faktor, seperti karakter dari guru dan murid itu sendiri, kurang terbukanya murid terhadap gurunya, tidak adanya empati guru kepada murid yang menghadapi masalah, selalu berfikir negatif kepada gurunya, sehingga dari hal tersebut dapat menyebabkan kerenggangan dalam komunikasi antara guru dan murid. Jika hal tersebut sering terjadi, maka proses komunikasi ini tidak sesuai dengan  prinsip dari teori Humanistik yang dibawakan oleh Joseph A. Davito tentang empat indikator yang terkait teori Humanistiknya yaitu, Keterbukaan, Empati, Sikap Mendukung, dan Sikap Positif. Tujuan dari penelitian ini adalah untuk menganalisis konsep teori Humanistik Joseph A. Devito dengan kesesuaian dari konsep kitab Ta’lim Muta’allim dan menganalisis pola komunikasi guru dengan murid dalam kitab Ta’lim Muta’allim  di Pondok Pesantren Qodratullah. Metode yang digunakan dalam penelitian ini ialah metode kualitatif deskriptif, dengan lokasi penelitian di Pondok Pesantren Qodratullah Langkan, data ini dikumpulkan dengan menggunakan metode Observasi, Wawancara, Dokumentasi, dan Analisis Data. Responden dalam penilitian ini sebanyak 4 orang guru yang mengajar kitab Ta'lim Muta'allim, dan 20 orang murid yang sudah mempelajari kitab Ta'lim Muta'allim, yang terdiri dari 10 murid dari MTs Putra dan Putri, dan 10 Murid dari MA Putra dan Putri. Hasil penelitian menunjukkan Pola komunikasi interpersonal antara guru dan murid yang ada dalam kitab Ta’lim Muta’alim yang ada di bab IV sejalan dengan konsep humanistik yang digagas oleh Devito, dan sesuai dengan penerapan yang ada di Pondok Pesantren Qodratullah, yang mana dalam komunikasi interpersonal tersebut mengandung lima unsur yang telah ditekankan oleh Devito, yaitu: Keterbukaan, empati, sifat mendukung, sikap positif, dan kesetaraan.
The Effect of Variety on Perceived Quantity
Authors: Röseler Lukas , Felser Georg , Asberger Jana , Schütz Astrid
Published: August 2024

Redden and Hoch (2009) found that variety in a set of items robustly decreased the perceived quantity of the sum of these items across multiple studies. For example, a set of multicolored M&M’s was estimated to contain fewer M&M’s than an equally large set of single-colored M&M’s (e.g., Redden & Hoch, 2009, Study 3). We conducted six close replication studies of the studies reported by Redden and Hoch and did not find this effect in any of them. A meta-analysis of the four original studies and 6 replication studies (N = 1,383) revealed no evidence for the phenomenon that variety reduces perceived quantity.
Mackey convergence and separation in $(L, M)$-fuzzy bornological vector spaces
Authors: Shen Yu , Yan C. H.
Published: August 2024

This paper aims to introduce the concepts of Mackey convergence degree for sequences and separation degree for spaces in $(L, M)$-fuzzy bornological vector spaces. Additionally, the paper presents the concept of bornological closure degree for fuzzy sets. Moreover, the paper discusses various characteristics of these concepts. Furthermore, the paper examines the degree relationships among a Mackey convergence sequence, a separated space, and a bornologically closed fuzzy set. Finally, the paper analyzes the properties of functors $\omega$ and $\iota$ between $M$-fuzzifying bornological vector spaces and $(L, M)$-fuzzy bornological vector spaces in terms of Mackey convergence degree and separation degree.
Approximate Controllability Result for Backward Stochastic Evoluation Inclusions in Hilbert Spaces
Authors: Temel Cesim , Selah Müberra
Published: August 2024

In this paper, we study semilinear Backward Stochastic Evolution Inclusion systems in Hilbert spaces. First, we prove the existence of mild solution of the semilinear Backward Stochastic Evolution Inclusion systems using a multivalued fixed point theorem. Then, we obtain the approximate controllability result for semilinear Backward Stochastic Evolution Inclusion systems through the linear systems corresponding to these semilinear Backward Stochastic Evolution Inclusion systems under appropriate conditions. In particular, our study extends the results of the concept of approximate controllability to Backward Stochastic Evolution Inclusion systems.