bluuebunny/crossref_metadata_2025 huggingface dataset:
Inductive limit of direct sums of simple TAI algebras
Authors: Cui Bo , Jiang Chunlan , Li Liangqing
Published: June 2019

An ATAI (or ATAF, respectively) algebra, introduced in [C. Jiang, A classification of non simple C*-algebras of tracial rank one: Inductive limit of finite direct sums of simple TAI C*-algebras, J. Topol. Anal. 3 (2011) 385–404] (or in [X. C. Fang, The classification of certain non-simple C*-algebras of tracial rank zero, J. Funct. Anal. 256 (2009) 3861–3891], respectively) is an inductive limit [Formula: see text], where each [Formula: see text] is a simple separable nuclear TAI (or TAF) C*-algebra with UCT property. In [C. Jiang, A classification of non simple C*-algebras of tracial rank one: Inductive limit of finite direct sums of simple TAI C*-algebras, J. Topol. Anal. 3 (2011) 385–404], the second author classified all ATAI algebras by an invariant consisting orderd total [Formula: see text]-theory and tracial state spaces of cut down algebras under an extra restriction that all element in [Formula: see text] are torsion. In this paper, we remove this restriction, and obtained the classification for all ATAI algebras with the Hausdorffized algebraic [Formula: see text]-group as an addition to the invariant used in [C. Jiang, A classification of non simple C*-algebras of tracial rank one: Inductive limit of finite direct sums of simple TAI C*-algebras, J. Topol. Anal. 3 (2011) 385–404]. The theorem is proved by reducing the class to the classification theorem of [Formula: see text] algebras with ideal property which is done in [G. Gong, C. Jiang and L. Li, A classification of inductive limit C*-algebras with ideal property, preprint (2016), arXiv:1607.07681]. Our theorem generalizes the main theorem of [X. C. Fang, The classification of certain non-simple C*-algebras of tracial rank zero, J. Funct. Anal. 256 (2009) 3861–3891], [C. Jiang, A classification of non simple C*-algebras of tracial rank one: Inductive limit of finite direct sums of simple TAI C*-algebras, J. Topol. Anal. 3 (2011) 385–404] (see Corollary 4.3).
Influence of structural highs on Triassic deposition on the western Barents Shelf
Authors: Anell I. , Indrevær K. , Serck C. S.
Published: June 2019

While the Triassic is comparatively a tectonically quiescent period in the dynamic development of the Barents Shelf, the depositional infill was strongly influenced by structural elements and there is a marked difference between lower and middle Triassic sedimentation. Southwards-propagating uplift of north–south-orientated elements along the incipient North Atlantic margin, from the mid-Carboniferous to the Early Triassic, generated uplift, tilt and erosion of the Sørkapp–Hornsund and palaeo-Stappen highs, and the Ringsel and Selis ridges. Progressive onlap along the flanks with probably no deposition until the Ladinian, which is probably condensed/partly missing, characterized the ensuing sedimentation. Late Permian–Early Triassic uplift of the Selis Ridge was concurrent with uplift and erosion of the Capria Ridge. Both elements also experienced a phase of Anisian–Ladinian erosion. The Gardarbanken High underwent a later Early Triassic uplift and a complex, probably condensed, deposition associated with the infill of advancing deltaic systems. The Ladinian, and more dominantly the Carnian, saw even blanketing of large parts of the Barents Shelf, almost wholly unaffected by the structural elements. The most noticeable influence at the time is the thinning of the progradational system approaching the Svalbard Platform, which remained comparatively shallow, as witnessed by the lowered clinoform angle and rapid deposition.
Stress-Induced Performance Shifts in 3D DRAMs
Authors: Li Tengtao , Sapatnekar Sachin S.
Published: June 2019

3D-stacked DRAMs can significantly increase cell density and bandwidth while also lowering power consumption. However, 3D structures experience significant thermomechanical stress due to the differential rate of contraction of the constituent materials, which have different coefficients of thermal expansion. This impacts circuit performance. This article develops a procedure that performs a performance analysis of 3D DRAMs, capturing the impact of both layout-aware stress and layout-independent stress on parameters such as latency, leakage power, refresh power, area, and bus delay. The approach first proposes a semianalytical stress analysis method for the entire 3D DRAM structure, capturing the stress induced by through-silicon-vias (TSVs), micro bumps, package bumps, and warpage. Next, this stress is translated to variations in device mobility and threshold voltage, after which analytical models for latency, leakage power, and refresh power are derived. Finally, a complete analysis of performance variations is performed for various 3D DRAM layout configurations to assess the impact of layout-dependent stress. We explore the use of alternative flexible package substrate options to mitigate the performance impact of stress. Specifically, we explore the use of an alternative bendable package substrate made of polyimide to reduce warpage-induced stress, and show that it reduces stress-induced variations and improves the performance metrics for stacked 3D DRAMs.
Interdependence of hypoxia and β-adrenergic receptor signaling in pulmonary arterial hypertension
Authors: Stephens Olivia R. , Weiss Kelly , Frimel Matthew , Rose Jonathan A. , Sun Yu , Asosingh Kewal , Farha Samar , Highland Kristin B. , Prasad Sathyamangla V. Naga , Erzurum Serpil C.
Published: June 2019

The β-adrenergic receptor (βAR) exists in an equilibrium of inactive and active conformational states, which shifts in response to different ligands and results in downstream signaling. In addition to cAMP, βAR signals to hypoxia-inducible factor 1 (HIF-1). We hypothesized that a βAR-active conformation (R**) that leads to HIF-1 is separable from the cAMP-activating conformation (R*) and that pulmonary arterial hypertension (PAH) patients with HIF-biased conformations would not respond to a cAMP agonist. We compared two cAMP agonists, isoproterenol and salbutamol, in vitro. Isoproterenol increased cAMP and HIF-1 activity, while salbutamol increased cAMP and reduced HIF-1. Hypoxia blunted agonist-stimulated cAMP, consistent with receptor equilibrium shifting toward HIF-activating conformations. Similarly, isoproterenol increased HIF-1 and erythropoiesis in mice, while salbutamol decreased erythropoiesis. βAR overexpression in cells increased glycolysis, which was blunted by HIF-1 inhibitors, suggesting increased βAR leads to increased hypoxia-metabolic effects. Because PAH is also characterized by HIF-related glycolytic shift, we dichotomized PAH patients in the Pulmonary Arterial Hypertension Treatment with Carvedilol for Heart Failure trial (NCT01586156) based on right ventricular (RV) glucose uptake to evaluate βAR ligands. Patients with high glucose uptake had more severe disease than those with low uptake. cAMP increased in response to isoproterenol in mononuclear cells from low-uptake patients but not in high-uptake patients’ cells. When patients were treated with carvedilol for 1 wk, the low-uptake group decreased RV systolic pressures and pulmonary vascular resistance, but high-uptake patients had no physiologic responses. The findings expand the paradigm of βAR activation and uncover a novel PAH subtype that might benefit from β-blockers.
In human nephrectomy specimens, the kidney level of tubular transport proteins does not correlate with their abundance in urinary extracellular vesicles
Authors: Sabaratnam Rugivan , Geertsen Louise , Skjødt Karsten , Højlund Kurt , Dimke Henrik , Lund Lars , Svenningsen Per
Published: June 2019

Human urinary extracellular vesicles (uEVs) contain proteins from all nephron segments. An assumption for years has been that uEVs might provide a noninvasive liquid biopsy that reflect physiological regulation of transporter protein expression in humans. We hypothesized that protein abundance in human kidney tissue and uEVs are directly related and tested this in paired collections of nephrectomy tissue and urine sample from 12 patients. Kidney tissue was fractioned into total kidney protein, crude membrane (plasma membrane and large intracellular vesicles)-enriched, and intracellular vesicle-enriched fractions as well as sections for immunolabeling. uEVs were isolated from spot urine samples. Antibodies were used to quantify six segment-specific proteins [proximal tubule-expressed Na+-phosphate cotransporters (NaPi-2a), thick ascending limb-expressed Tamm-Horsfall protein and renal outer medullary K+channels, distal convoluted tubule-expressed NaCl cotransporters, intercalated cell-expressed V-type H+-ATPase subunit G3 (ATP6V1G3), and principal cell-expressed aquaporin 2] and three uEV markers (exosomal CD63, microvesicle marker vesicle‐associated membrane protein 3, and β-actin) in each fraction. By Western blot analysis and immunofluorescence labeling, we found significant positive correlations between the abundance of CD63, NaCl cotransporters, aquaporin 2, and ATP6V1G3, respectively, within the different kidney-derived fractions. We detected all nine proteins in uEVs, but their level did not correlate with kidney tissue protein abundance. uEV protein levels showed higher interpatient variability than kidney-derived fractions, indicating that factors, besides kidney protein abundance, contribute to the uEV protein level. Our data suggest that, in a random sample of nephrectomy patients, uEV protein level is not a predictor of kidney protein abundance.
Renal T cell infiltration occurs despite attenuation of development of hypertension with hydralazine in Envigo’s female Dahl rat maintained on a low-Na+diet
Authors: Pai Amrita V. , West Crystal A. , de Souza Aline M. Arlindo , Kadam Parnika S. , Pollner Emma J. , West David A. , Li Jia , Ji Hong , Wu Xie , Zhu Michelle J. , Baylis Chris , Sandberg Kathryn
Published: June 2019

Many studies have suggested that renal T cell infiltration contributes to the pathogenesis of salt-sensitive hypertension. To investigate this mechanism further, we determined T cell profiles in the kidney and lymphoid tissues as a function of blood pressure in the female Envigo Dahl salt-sensitive (SS) rat maintained on low-Na+(LS) diet. Mean arterial pressure and heart rate were measured by telemetry in SS rats from 1 mo old (juvenile) to 4 mo old. Normotensive salt-resistant (SR) rats were included as controls. Frequencies of T helper (CD4+) cells were greater in the kidney, lymph nodes, and spleen in 4-mo-old hypertensive SS rats compared with normotensive SR animals and SS juvenile rats, suggesting that renal T cell infiltration contributes to hypertension in the SS rat on a LS diet. At 1.5 mo, half of the SS rats were treated with vehicle (Veh), and the rest received hydralazine (HDZ; 25 mg·kg−1·day−1) for 11 wk. HDZ impeded the development of hypertension compared with Veh-treated control rats [mean arterial pressure: 157 ± 4 mmHg in the Veh-treated group ( n = 6) vs. 133 ± 3 mmHg in the HDZ-treated group ( n = 7), P < 0.001] without impacting T helper cell frequencies in the tissues, suggesting that HDZ can overcome mechanisms of hypertension driven by renal T cell infiltration under the LS diet. Renal frequencies of CD4+CD25+and CD4+CD25+FoxP3+regulatory T cells were significantly higher in 4-mo-old hypertensive rats compared with normotensive SR rats and SS juvenile rats, suggesting that these T cell subpopulations play a compensatory role in the development of hypertension. Greater understanding of these T cell populations could lead to new therapeutic targets for treating inflammatory diseases associated with hypertension.
Spironolactone reduces oxidative stress in living donor kidney transplantation: a randomized controlled trial
Authors: Morales-Buenrostro Luis Eduardo , Ortega-Trejo Juan Antonio , Pérez-Villalva Rosalba , Marino Lluvia A. , González-Bobadilla Yvett , Juárez Hilda , Zamora-Mejía Flor M. , González Norma , Espinoza Ramón , Barrera-Chimal Jonatan , Bobadilla Norma A.
Published: June 2019

Mineralocorticoid receptor antagonism prevents acute kidney injury induced by ischemia-reperfusion in rodent and pig preclinical models. In a pilot study, we showed that spironolactone (25 mg) reduced oxidative stress after 5 days of kidney transplant (KT). In the present study, we investigated the effects of higher doses (50 and 100 mg) of spironolactone on kidney function, tubular injury markers, and oxidative stress in living donor KT recipients. We included KT recipients aged 18 yr or older who received immunosuppression therapy with IL-2 receptor antagonist, mycophenolate mofetil, corticosteroids, and tacrolimus with negative cross-match, and compatible blood group. Patients were randomized to receive placebo ( n = 27), spironolactone (50 mg, n = 25), or spironolactone (100 mg, n = 25). Treatment was given from 3 days before and up to 5 days after KT. Serum creatinine, K+, urine neutrophil gelatinase-associated lipocalin-2, heat shock protein 72, and 8-hydroxy-2-deoxyguanosine levels were assessed. As expected, kidney function was improved after KT. Serum K+ remained in the normal range along the study. There was no significant effect of spironolactone on urinary neutrophil gelatinase-associated lipocalin-2 levels, whereas the increase in urinary heat shock protein 72 levels tended to be less intense in the 100 mg spironolactone-treated group ( P = 0.054). In the placebo-treated group, urinary 8-hydroxylated-guanosine levels increased on days 3 and 5 after transplantation. This effect was prevented in patients that received spironolactone. In conclusion, spironolactone reduces the acute increase in urinary oxidative stress in living donor KT recipients.
Electrophysiological responses to lateral shifts are not consistent with opponent-channel processing of interaural level differences
Authors: Ozmeral Erol J. , Eddins David A. , Eddins Ann Clock
Published: June 2019

Cortical encoding of auditory space relies on two major peripheral cues, interaural time difference (ITD) and interaural level difference (ILD) of the sounds arriving at a listener’s ears. In much of the precortical auditory pathway, ITD and ILD cues are processed independently, and it is assumed that cue integration is a higher order process. However, there remains debate on how ITDs and ILDs are encoded in the cortex and whether they share a common mechanism. The present study used electroencephalography (EEG) to measure evoked cortical potentials from narrowband noise stimuli with imposed binaural cue changes. Previous studies have similarly tested ITD shifts to demonstrate that neural populations broadly favor one spatial hemifield over the other, which is consistent with an opponent-channel model that computes the relative activity between broadly tuned neural populations. However, it is still a matter of debate whether the same coding scheme applies to ILDs and, if so, whether processing the two binaural cues is distributed across similar regions of the cortex. The results indicate that ITD and ILD cues have similar neural signatures with respect to the monotonic responses to shift magnitude; however, the direction of the shift did not elicit responses equally across cues. Specifically, ITD shifts evoked greater responses for outward than inward shifts, independently of the spatial hemifield of the shift, whereas ILD-shift responses were dependent on the hemifield in which the shift occurred. Active cortical structures showed only minor overlap between responses to cues, suggesting the two are not represented by the same pathway.

NEW & NOTEWORTHY Interaural time differences (ITDs) and interaural level differences (ILDs) are critical to locating auditory sources in the horizontal plane. The higher order perceptual feature of auditory space is thought to be encoded together by these binaural differences, yet evidence of their integration in cortex remains elusive. Although present results show some common effects between the two cues, key differences were observed that are not consistent with an ITD-like opponent-channel process for ILD encoding.
Functional Corticomuscular Signal Coupling Is Weakened during Voluntary Motor Action in Cancer-Related Fatigue
Authors: Jiang Changhao , Yang Qi , Chen Tingting , Siemionow Vlodek , Ranganathan Vinoth K. , Yan Alice F. , Yue Guang H.
Published: June 2019

Background and Purpose. Cancer-related fatigue (CRF) is widely recognized as one of the most common symptoms and side effects of cancer and/or its treatment. However, neuropathological mechanisms contributing to CRF are largely unknown, and the lack of knowledge makes CRF difficult to treat. Recent research has shown dissociation between changes in the brain and muscle signals during voluntary motor performance in cancer survivors with CRF, and this dissociation may be caused by an interruption in functional coupling (FC) of the two signals. The goal of this study was to assess the FC between EEG (cortical signal) and EMG (muscular signal) in individuals with CRF and compare the FC with that of healthy controls during a motor task that led to progressive muscle fatigue. Method. Eight cancer survivors with CRF and nine healthy participants sustained an isometric elbow flexion contraction (at 30% maximal level) until self-perceived exhaustion. The entire duration of the EEG and EMG recordings was divided into the first-half (less-fatigue stage) and second-half (more-fatigue stage) artifact-free epochs without overlapping. The EEG-EMG coupling (measured by coherence of the two signals) in each group and stage was computed. Coherence values at different frequencies were statistically analyzed using a repeated-measure general linear model. Results. The results demonstrated that compared to healthy controls, CRF participants sustained the contraction for a significantly shorter time and exhibited robust and significantly lower EEG-EMG coherence at the alpha (8~14 Hz) and beta (15~35 Hz) frequency bands. Both the CRF and healthy control groups exhibited significantly decreased EEG-EMG coherence from the less-fatigue to more-fatigue stages at the alpha and beta frequency bands, indicating fatigue-induced weakening of functional corticomuscular coupling. Conclusion. Impaired functional coupling between the brain and muscle signals could be a consequence of cancer and/or its treatment, and it may be one of the contributing factors to the abnormal feeling of fatigue that caused the early failure of sustaining a prolonged motor task.
Effect of Ultrasonic Flexural Vibration on Solidification Structure and Mechanical Properties of Large-Size 35CrMoV Cast Ingot
Authors: Shi Chen , Li Fan , Wu Yongjun , Mao Daheng
Published: June 2019

In order to improve the performances of large-size 35CrMoV cast ingot, ultrasonic flexural vibration was guided into 35CrMoV steel melt through L-shaped ultrasonic waveguide rod during the solidification, and the effects of ultrasonic flexural vibration on macrostructure, microstructure, and mechanical properties of large-size 35CrMoV cast ingot were investigated. It is found that the columnar crystal zone has disappeared and the ingot is composed of the equiaxed crystals present in the ultrasonic ingot. The size of grains treated by ultrasonic are significantly smaller than conventional ingot. The distribution of ferrite in matrix structure is also more uniform than conventional ingot. The tensile strength is increased by 3.14%∼17.12%, and the elongation is increased by 39.13%∼287.50% compared with the conventional ingot at different positions.
Selective Laser Melting of Diamond-Containing or Postnitrided Materials Intended for Impact-Abrasive Conditions: Experimental and Analytical Study
Authors: Rahmani Ramin , Antonov Maksim , Kollo Lauri
Published: June 2019

Materials with higher wear resistance are required in various applications including cutting elements (drag bits) of soft ground tunnel boring machines (TBM) to increase the productivity and to reduce the risk for workers involved in exchange operations (dangerous hyperbolic conditions). In recent work, two types of materials were produced by combining 3D printing (selective laser melting, SLM) of cellular lattice structures and spark plasma sintering (SPS) methods. The lattices were printed from (1) 316L stainless steel with diamond and (2) Ti6Al4V with nitriding. The effect of diamond content (5%, 10%, and 20%; nickel-coated particles) and unit cell size on performance was studied. The titanium alloy lattice was nitrided to increase its hardness and wear resistance. The effect of nitriding temperature (750°C, 900°C, and 1050°C) and lattice volume fraction (6%, 15%, and 24%, vol.) was investigated, and the optimized conditions were applied. The lattices were filled with 316L and Ti6Al4V powders, respectively, and consolidated by SPS. Samples were tested with the help of laboratory impact-abrasive tribodevice. Laboratory results have shown that both reinforcing approaches are beneficial and allow improvement of wear resistance in impact-abrasive conditions with great potential for TBM or similar applications. Modelling with the help of finite element method has shown that lattice structure enables reduction of peak local stresses in scratching and impact conditions.
Etiologic Spectrum of Intestinal Obstruction in Ningxia District: A Retrospective Analysis of 4908 Cases in a 10-Year Period
Authors: Jiang Wei , Li Wenyan , Hao Qian , Yao Yuping , Li Yajun , Ge Jun , Zhai Huihong
Published: June 2019

Background. Economic disparity contributes to the variation of intestinal obstruction (IO) etiologic spectrum. Clarifying the etiology distribution in local regions can help to unravel IO and promote early diagnosis, henceforth making sure standardized therapeutic interventions. Methods. Medical data of 4908 inpatients diagnosed with IO admitted to the General Hospital of Ningxia Medical University between January 2004 and December 2013 were recruited and analyzed retrospectively. The associated profiles included demographic features, clinical manifestations, and previous therapeutic operations. Results. 4908 cases of intestinal obstruction were identified during the period of study. It denoted that the hospitalization rate of IO has maintained upward momentum; the top four causes of IO were adhesion, tumor, intussusception, and hernias. These covered up nearly 80% of the total constitution. Among them, adhesive intestinal obstruction accounted for 45.17%, malignant bowel obstruction for 21.09%, intussusception for 8.72%, and hernia for 4.73%; abdominal surgery constituted for the majority (78.62%) of adhesive obstruction. The followed up analysis also found that appendectomy accounted for the biggest percentage, 28% of operation cases. Malignant bowel obstruction can have a rate of 96.43% in 1035 cases led by tumor lesions. Of which, the primary intestinal malignant tumor accounted for 68.64% and metastatic tumors for 31.36%. Nearly 50% occurred in the large intestine. The overall mortality of all 4908 cases was 4.7%. Conclusion. The hospitalizations of IO delineated an increasing trend. Adhesion was the main etiology in IO. The odds of malignant bowel obstruction was increasing in the proportion of IO. There were some differences towards the etiologic spectrum compared with western countries.
Field Tests and Simplified Calculation Method for Static Drill Rooted Nodular Pile
Authors: Wang Zhong-Jin , Zhang Ri-Hong , Xie Xin-Yu , Fang Peng-Fei , Zheng Ling-Wei , Li Jin-Zhu , Zhu Da-Yong
Published: June 2019

In order to explore bearing characteristics of a new‐type static drill rooted nodular pile foundation (SDRN), which is composed of PHC pile, bamboo joint pile, and cement soils, field tests of three piles were carried out by embedding internal rebar stress gauges to collect test data. The test results show that the SDRN piles were under elastic state and the load‐settlement curves changed slowly before reaching the ultimate capacity. As pile head loads increased, the pile shaft frictions developed progressively, and axial forces gradually reduced along pile depths. Taking into account the interaction between the pile, the cement soils, and surrounding soils, a simplified method for calculating settlements and bearing capacity of SDRN piles was proposed. With corresponding parameters, the computing results obtained by the proposed method were compared with the field experimental data, which indicates acceptable agreements; thus, it is concluded that the applicability and predictive capability of the proposed method were verified.
Description of Two Cases of Anaplastic Large Cell Lymphoma Associated with a Breast Implant
Authors: Crèvecoeur Julie , Jossa Véronique , Somja Joan , Parmentier Jean-Claude , Nizet Jean-Luc , Crèvecoeur André
Published: June 2019

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a recently recognized provisional entity in the 2017 revision of the World Health Organization classification of lymphoid neoplasms. Although the majority of the cases described in the literature demonstrate an effusion confined to the capsule of the breast implant, this rare pathology can also invade the capsule and adjacent tissues and/or involve lymph nodes. We hereby report two new cases of BIA-ALCL in a 58-year-old and a 47-year-old Caucasian female who received a silicone breast implant. The first patient showed a sudden and rapid right breast volume increase 6 years after the implantation surgery. As for the second patient, a left breast volume increase was observed also suddenly and quickly 11 years after surgery. In both cases, an uncompressed mammography was performed allowing a new approach to highlight periprosthetic fluid reaction. Pathologic examination of the fluid collection revealed atypical cells positive for CD30 and CD45 and negative for ALK and CK7. This allowed pathologists to diagnose a breast implant-associated anaplastic large cell lymphoma. Patients were treated with bilateral capsulectomy with no additional local or systemic therapy. The development of breast augmentation may come with an increase in the frequency of this pathology. Radiologists and senologists must therefore be careful when women with breast implants show an increase of breast volume and all cases of BIA-ALCL must be recorded and reported.
In SilicoScreening of Aptamers Configuration against Hepatitis B Surface Antigen
Authors: Sabri Mohamad Zulkeflee , Abdul Hamid Azzmer Azzar , Sayed Hitam Sharifah Mariam , Abdul Rahim Mohd. Zulkhairi
Published: June 2019

Aptamer has been long studied as a substitute of antibodies for many purposes. However, due to the exceeded length of the aptamers obtainedin vitro, difficulties arise in its manipulation during its molecular conjugation on the matrix surfaces. Current study focuses on computational improvement for aptamers screening of hepatitis B surface antigen (HBsAg) through optimization of the length sequences obtained from SELEX. Three original aptamers with affinity against HBsAg were truncated into five short hairpin structured aptamers and their affinity against HBsAg was thoroughly studied by molecular docking, molecular dynamics (MD) simulation, and Molecular Mechanics Poisson-Boltzmann Surface Area (MMPBSA) method. The result shows that truncated aptamers binding on HBsAg “a” determinant region are stabilized by the dynamic H-bond formation between the active binding residues and nucleotides. Amino acids residues with the highest hydrogen bonds hydrogen bond interactions with all five aptamers were determined as the active binding residues and further characterized. The computational prediction of complexes binding will include validations through experimental assays in future studies. Current study will improve the currentin vitroaptamers by minimizing the aptamer length for its easy manipulation.
Real-World Evidence from the Integrative Medicine Primary Care Trial (IMPACT): Assessing Patient-Reported Outcomes at Baseline and 12-Month Follow-Up
Authors: Crocker Robert L. , Hurwitz Jason T. , Grizzle Amy J. , Abraham Ivo , Rehfeld Rick , Horwitz Randy , Weil Andrew T. , Maizes Victoria
Published: June 2019

Purpose. The University of Arizona Integrative Health Center (UAIHC) was an innovative membership-supported integrative medicine (IM) adult primary care clinic in Phoenix, Arizona. UAIHC delivered healthcare using an integrative medicine model that combined conventional and complementary medical treatments, including nutrition, mind-body medicine, acupuncture, manual medicine, health coaching, educational classes, and groups. Results from pre-post evaluation of patient-reported outcomes on several standardized measures are presented here. Methods. UAIHC patients completed surveys at baseline and after 12 months of continuous integrative primary care. Patients reported on perceived changes in health outcomes as measured by Short-Form Health Survey (SF-12 general, mental, and physical health), Perceived Stress Scale (PSS4), Work Productivity and Activity Impairment Questionnaire (WPAI), World Health Organization Well-Being Index (WHO-5), Pain Visual Analog Scale (VAS), Fatigue Severity Scale (VAS; FSS), Generalized Anxiety Disorder Scale (GAD2), Patient Health Questionnaire for depression (PHQ2), Pittsburgh Sleep Quality Index (PSQI) global rating of sleep quality, and the Behavioral Risk Factor Surveillance System (BRFSS; nutrition, exercise, and physical activity). Overall differences between time points were assessed for statistical significance. Patient demographics are also described. Results. 177 patients completed baseline and follow-up outcome measures. Patients were predominantly white, female, college-educated, and employed. Baseline to one-year follow-up results indicate statistically significant improvements (p < .05) on all but perceived stress (PSS-4) and work absenteeism (WPAI). Clinical impact and/or practical effects are reported as percent change or standardized effect sizes whenever possible. Other demographic and descriptive information is summarized. Conclusions. Following one year of IM primary care at UAIHC, patient-reported outcomes indicated positive impacts in several areas of patients’ lives: mental, physical, and overall health; work productivity; sleep quality; pain; fatigue; overall well-being; and physical activity.
Vision-Based Deep Q-Learning Network Models to Predict Particulate Matter Concentration Levels Using Temporal Digital Image Data
Authors: Kim SungHwan , Jung SeHee , Yang SeongMin , Han JiSeong , Lee ByungYong , Lee JaeHwa , Han Sung Won
Published: June 2019

Particulate matter (PM) has been revealed to have detrimental effects on public health, social economy, agriculture, and so forth. Thus, it became one of the major concerns in terms of a factor that can reduce “quality of life” over East Asia, where the concentration is significantly high. In this regard, it is imperative to develop affordable and efficient prediction models to monitor real-time changes in PM concentration levels using digital images, which are readily available for many individuals (e.g., via mobile phone). Previous studies (i.e., DeepHaze) were limited in scope to priorly collected data and thereby less practical in providing real-time information (i.e., undermined interprediction). This drawback led us to hardly capture drastic changes caused by weather or regions of interests. To address this challenge, we propose a new method called Deep Q-haze, whose inference scheme is built on an online learning-based method in collaboration with reinforcement learning and deep learning (i.e., Deep Q-learning), making it possible to improve testing accuracy and model flexibility in virtue of real-time basis inference. Taking into account various experiment scenarios, the proposed method learns a binary decision rule on the basis of video sequences to predict, in real time, whether the level of PM10 (particles smaller than 10 in aerodynamic diameter) concentration is harmful (>80μg/m3) or not. The proposed model shows superior accuracy compared to existing algorithms. Deep Q-haze effectively accounts for unexpected environmental changes in essence (e.g., weather) and facilitates monitoring of real-time PM10 concentration levels, showing implications for better understanding of characteristics of airborne particles.
From Smart Homes to Smart-Ready Homes and Communities
Authors: Helal Sumi , Bull Christopher N.
Published: June 2019

Background: People have various and changing needs as they age, and the number of people living with some form of dementia is steadily increasing. Smart homes have a unique potential to provide assisted living but are often designed rigidly with a specific and fixed problem in mind. Objectives: To make smart-ready homes and communities that can be adaptively and easily updated over time to support varying user needs and to deliver the needed assistance, empowerment, and living independence. Method: The design and deployment of programmable assistive environment for older adults. Results: The use of platform technology (a special form of what is known today as the Internet of Things or IoT) has enabled the decoupling of goal setting and application development from sensing and assistive technology deployment and insertion in the assistive environment. Personalising a smart home or changing its applications and its interfaces dynamically as the user needs change was possible and has been demonstrated successfully in one house – the Gator Tech Smart House. Scaling up the platform technology approach to a planned living community is underway at one of UK’s National Health Services (NHS) Healthy New Town projects. Conclusions: There is a great need to integrate technology with living spaces to provide assistance and independent living, but to smarten these spaces for lifelong living, the technology and the smart home applications must be flexible, adaptive, and changeable over time. However, people do not just live at home, they live in communities. Looking at the big picture (communities), as well as the small (homes), we consider how to progress beyond smart-ready homes towards smart-ready communities.
Brexit na perspectiva do Path Dependency
Authors: Schutte Giorgio Romano
Published: June 2019

Esta pesquisa analisou o Brexit em uma perspectiva histórica, focando a conturbada relação entre a Europa continental e o Reino Unido ao longo do século XX, com ênfase no período pós Segunda Guerra Mundial. Foi utilizado o conceito de path dependency para argumentar sobre o papel de fatores históricos e decisões do passado, embora tomados em outras circunstâncias, ainda com força para influenciar o presente, para entender o Brexit. A premissa básica que será apresentada no ensaio é que o Reino Unido nunca participou de fato da ideia da Europa e sempre se viu como um país diferente por sua história e seu papel no mundo. Quando entrou, foi com uma perna só, a outra sempre ficou atrás, inclusive devido às especificidades de sua estrutura econômica herdada do passado, em particular no que diz respeito à agricultura. Desta forma, defende-se que, embora longe de ter sido inevitável, se tratou de um fenômeno limitado ao Reino Unido que tinha pouquíssima probabilidade de se repetir em outros países da União Europeia.
Estratégia geopolítica e hegemonia de classe: para uma análise materialista-histórica de política externa
Authors: Apeldoom Bastiaan Van
Published: June 2019

Este artigo procura estabelecer os fundamentos para uma análise materialistahistórica de política externa. Embora exista uma vasta literatura marxista sobre, especialmente, o imperialismo estadunidense, é pequeno o número de pesquisas empíricas sistematizadas sobre formulação de política externa nessa perspectiva. A maioria das contribuições nessa tradição, incluindo as mais recentes do debate sobre o “novo imperialismo”, são geralmente exercícios abstratos em grande teoria – importantes e perspicazes, mas não necessariamente direcionados à pesquisa empírica. De outro lado, os estudos mais empíricos que existem sobre formulação de política externa (estadunidense) geralmente tendem a sofrer com a falta de teorização adequada. Procurando suprir essa lacuna este artigo primeiramente examina de forma crítica a atual (e crescente) literatura materialista-histórica sobre a geopolítica (e suas ligações com o capitalismo global) e então busca ir além, oferecendo uma estrutura [F]2 analítica que pode ser aplicada em pesquisa empírica. Um ponto de partida teórico é o que Harvey identifica como as lógicas territorial e capitalista de poder, dialética e intrinsicamente relacionadas. Mas considerando que muitos acadêmicos materialista-históricos concordariam com essa noção abstrata, a questão é não apenas por que mas também como (na prática) elas estão relacionadas e como podemos estudar os efeitos dessa relação intrínseca. Para tal, argumentamos que é preciso ir além de postular lógica(s) abstrata(s) e analisar a agência concreta das forças sociais que constituem o elo entre Estado e capital. Argumentamos que a classe é a força crucial de mediação e o elo perdido da literatura. Enfocar a classe e a estratégia de classe nos proporciona uma base para análise empírica e sistemática de processos concretos mediante os quais estratégias geopolíticas dos Estados capitalistas (a maioria) são formuladas e implementadas.
A intervenção judicial nos contratos de plano de saúde: uma análise da jurisprudência do Tribunal de Justiça de São Paulo
Authors: Lavecchia Amanda Leopoldo
Published: June 2019

O presente estudo tem como objetivo analisar a jurisprudência do Tribunal de Justiça do Estado de São Paulo (TJSP) que trata da relação contratual entre operadoras de plano de saúde e beneficiários, de modo a verificar a ocorrência da intervenção judicial nos anos de 2016 e 2017 e mapear os argumentos utilizados para tanto. A pesquisa foi feita com base em uma população de 38 decisões sobre o tema, e a análise dos dados levantados permitiu a criação da seguinte tipologia de motivos empregados pela corte: (i) intervenção fundamentada em princípios, (ii) intervenção fundamentada em súmulas; (iii) intervenção fundamentada no Código de Defesa do Consumidor; e (iv) intervenção fundamentada na legislação e na regulamentação específicas que norteiam os planos de saúde. Como resultado da pesquisa realizada, foi possível concluir que a intervenção judicial se revela como uma constante medida alternativa para efetivação do direito à saúde e que, em 95% das decisões do tribunal, mais de um motivo da tipologia criada se faz presente.
Report on three ectoparasites of the Greater Short-nosed Fruit Bat Cynopterus sphinx Vahl, 1797 (Mammalia: Chiroptera: Pteropodidae) in Cachar District of Assam, India
Authors: Rahman Anisur , Choudhury Parthankar
Published: June 2019

Ectoparasites of bats (Chiroptera: Pteropodidae), with a description of three species of of which two belong to order Mesostigmata (family: Ameroseiidae and Macronyssidae) and one belong to order Ixodida (family: Ixodidae), from northeastern India are discussed.  The present study was carried out for six months (January–June 2014) to identify the various ectoparasites of the Short-nosed Fruit Bat Cynopterus sphinx in Cachar District of Assam, northeastern India.  A total of 12 individuals of C. sphinx  was captured using mist nets from eight different localities of the study area.  During the study, a total of 125 parasites was collected from C. sphinx.  The identified parasites were Dermacentor sp. Indet., Ameroseius sp. Indet., and Steatonyssus sp. Indet. and falls under the class Arachnida.
Scully’s Balsam Impatiens scullyi Hook.f. (Balsaminaceae): a new record for India from Himachal Pradesh
Authors: Sharma Ashutosh , Singh Nidhan , Adamowski Wojciech
Published: June 2019

Impatiens scullyi Hook.f. is reported here as a new record for India as well as for the western Himalaya from Kullu and Mandi districts of Himachal Pradesh.  To facilitate its identification, detailed description along with colour images are provided here.
Pediatric Post–Cardiac Arrest Care: A Scientific Statement From the American Heart Association
Authors: Topjian Alexis A. , de Caen Allan , Wainwright Mark S. , Abella Benjamin S. , Abend Nicholas S. , Atkins Dianne L. , Bembea Melania M. , Fink Ericka L. , Guerguerian Anne-Marie , Haskell Sarah E. , Kilgannon J. Hope , Lasa Javier J. , Hazinski Mary Fran ,   On behalf of the American Heart Association Emergency Cardiovascular Care Science Subcommittee; American Heart Association Emergency Cardiovascular Care Pediatric Emphasis Group; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Genomic and Precision Medicine; and Stroke Council
Published: June 2019

Successful resuscitation from cardiac arrest results in a post–cardiac arrest syndrome, which can evolve in the days to weeks after return of sustained circulation. The components of post–cardiac arrest syndrome are brain injury, myocardial dysfunction, systemic ischemia/reperfusion response, and persistent precipitating pathophysiology. Pediatric post–cardiac arrest care focuses on anticipating, identifying, and treating this complex physiology to improve survival and neurological outcomes. This scientific statement on post–cardiac arrest care is the result of a consensus process that included pediatric and adult emergency medicine, critical care, cardiac critical care, cardiology, neurology, and nursing specialists who analyzed the past 20 years of pediatric cardiac arrest, adult cardiac arrest, and pediatric critical illness peer-reviewed published literature. The statement summarizes the epidemiology, pathophysiology, management, and prognostication after return of sustained circulation after cardiac arrest, and it provides consensus on the current evidence supporting elements of pediatric post–cardiac arrest care.
Structural Change and the Fertility Transition
Authors: Ager Philipp , Herz Benedikt , Brueckner Markus
Published: June 2019

This paper provides new insights into the relationship between structural change and the fertility transition. We exploit the spread of an agricultural pest in the American South in the 1890s as plausibly exogenous variation in agricultural production to establish a causal link between earnings opportunities in agriculture and fertility. Households staying in agriculture reduced fertility because children are a normal good, while households switching to manufacturing reduced fertility because of the higher opportunity costs of raising children. The lower earnings opportunities in agriculture also decreased the value of child labor, which increased schooling, consistent with a quantity-quality model of fertility.
Hydatothrips and Neohydatothrips (Thysanoptera, Thripidae) of East and South Asia with three new species from Taiwan
Authors: WANG CHIN-LING
Published: June 2019

The tribe Sericothripini is divided into three genera, Sericothrips Haliday, Hydatothrips Karny and Neohydatothrips John. The genera Corcithrips Bhatti, Faureana Bhatti, Pyrothrips Bhatti, Sariathrips Bhatti and Zonothrips Priesner are considered new synonyms of Hydatothrips. The genera Elbuthrips Bhatti and Kazinothrips Bhatti are considered new synonyms of Neohydatothrips. Keys to the 23 species of Hydatothrips and 16 species of Neohydatothrips in East and South Asia, including Taiwan, China, Korea, Japan, India, Malaysia and the neighboring areas are given. Neohydatothrips pectinarius Kudo is a new synonym of N. medius Wang, N. populi Han is new synonym of N. elaeagni Kudo, and Z. luridus Ananthakrishnan is a new synonym of N. plynopygus (Karny). This paper describes three new species from Taiwan, H. flavidus, H. meriposa, and N. surrufus, and records from Taiwan for the first time the following four species: N. gracilipes Hood, N. plynopygus (Karny), N. samayunkur Kudo and N. tabulifer (Priesner).
Endemic insects from the Yungas of Argentina
Authors: CUEZZO FABIANA , DE GROSSO MERCEDES LIZARRALDE , NAVARRO FERNANDO , SZUMIK CLAUDIA
Published: June 2019

Until now, biogeographic unit of the Yungas was almost exclusively characterized by its floristic taxa. Presence of other taxonomical groups, in this case arthropods, were poorly recorded besides implicit mention of arthropods to characterizeYungas as a natural region. We present herein a species checklist of the holometabolous insects considered as endemics of the Yungas in Argentina. This checklist is a result of a rigorous endemicity analysis (Navarro et al, en prep.) Comments about altitudinal gradients of distribution for these endemic species are made. Results reveal a total of 23 endemic insects species of Yungas, representing 13 families of Lepidoptera, Diptera and Hymenoptera。
XX International Congress of Zoology (26-29 August, 2008)
Authors: ZOOTAXA ZOOTAXA
Published: June 2019

Held every four years, the International Congress of Zoology (ICZ) gives zoologists and professionals from all fields related to zoology the chance to come together to discuss the current status of zoology and to share ideas about future development of all its disciplines.
Taxonomy of calcareous sponges (Porifera, Calcarea) from Potiguar Basin, NE Brazil
Authors: LANNA EMILIO , CAVALCANTI FERNANDA F. , CARDOSO LILIAN , MURICY GUILHERME , KLAUTAU MICHELLE
Published: June 2019

Relatively few calcareous sponges (Porifera, Calcarea) have been recorded from Brazil, mostly due to a reduced number of studies focused exclusively on these generally small, cryptic organisms. To fill in part this gap, the taxonomy and distribution of calcareous sponges from Potiguar Basin (Rio Grande do Norte state, Northeastern Brazil) are studied here. Thirty one specimens were collected by dredging, trawling and SCUBA diving from 2003 to 2007 from depths of 2 to 160 m. Seven species were found and are described here. Two of these species are new to science (Leucetta potiguar sp. nov. and Paraleucilla sphaerica sp. nov.), and four are new records for Rio Grande do Norte state (Clathrina aurea, Leucascus roseus, Leucetta floridana, and Leucandra serrata). An identification key for the species of Calcarea from Potiguar Basin is provided here.
A supplement of the genus Homogryllacris Liu, 2007 (Orthoptera: Gryllacrididae: Gryllacridinae) from China
Authors: LI YANQING , DOU YUJIE , SHI FUMING
Published: June 2019

In this paper, one new species of the genus Homogryllacris Liu, 2007, i.e. Homogryllacris obtusitubera sp. nov. and the previously unknown female of Homogryllacris brevispina Shi, Guo & Bian, 2012 are described from China. Meanwhile, the morphological photographs and habitus of these species are provided.
A new species of the late Miocene charadriiform bird (Aves: Charadriiformes), with a summary of all Paleogene and Miocene Charadrii remains
Authors: BOCHENSKI ZBIGNIEW M. , WERTZ KRZYSZTOF , TOMEK TERESA , GOROBETS LEONID
Published: June 2019

A new species, Cherevychnavis umanskae sp. nov., (Aves: Charadriiformes) from the late Miocene of Ukraine is described, and all known fossils of the suborder Charadrii from the Paleogene and Miocene are summarized. The combination of preserved characters allows us to assign the new species to the suborder Charadrii but its more exact systematic position remains uncertain. Morphologically, the new species is most similar to the extant Haematopus and Recurvirostra, and in terms of size to Haematopus, but it clearly differs from all extant genera of Charadrii. The current remains fill the temporal and spatial gaps in the fossil record of charadriiform birds; they constitute the first record of the Charadrii in eastern-most Europe, and add to our still insufficient knowledge of the late Miocene birds.