bluuebunny/crossref_metadata_2025 huggingface dataset:
Adherence to fertility preservation guidelines in young patients with breast cancer: A retrospective analysis.
Authors: Gonzalez-Gonzalez Luisa F. , Baylon Valdez Victor , Zamudio Lozoya Enrique Jose , Ochoa-Elizondo Patricio , Mendoza-Muraira Paolo , Martinez-Garcia Lascurain Regina , Martinez-Sanciprian Rafael , Bates Rodriguez Valeria , Mares García América Susana , Reza Bravo Gustavo Gil , Gonzalez Mendoza Rene Lazaro
Published: June 2024

e23255

Background: Breast cancer affects a considerable proportion of women of childbearing age making it important to provide options for fertility preservation. At Chihuahua's State Cancer Center, a state-federal-funded institution providing free oncological care, and ensuring access to fertility preservation measures is integral to the multidisciplinary approach for young cancer survivors. Recognizing chemotherapy's impact on fertility, implementing fertility preservation measures is key. Assessing adherence to these guidelines is essential for comprehensive care and holistic well-being in young breast cancer patients at our center. Methods: In this retrospective study at the Chihuahua´s State Cancer Center, we examined adherence to fertility preservation guidelines among breast cancer patients aged 18 to 40 years. The primary method used for fertility preservation was the administration of GnRH analogs, such as triptorelin and goserelin. Data on GnRH analog use, chemotherapy regimens, and patient demographics were collected from medical records. The study aimed to assess the integration of fertility preservation measures, particularly GnRH analogs, into treatment plans for young breast cancer patients. Additionally, we aimed to identify barriers to accessing fertility preservation services in this population. Results: The study findings revealed that out of the 749 registered breast cancer patients, 95 (12.6%) were 40 years old or younger. Among these, 75 (79%) received adjuvant and/or neoadjuvant chemotherapy, with 58 (77.3%) being in locally advanced clinical stages. Of the 75 patients who underwent chemotherapy, 20 (26.7%) also received GnRH analogs, while 55 (73.3%) did not. Among the 75 chemotherapy recipients, 16 (p = 0.046) were estrogen receptor-positive and received analogs. Furthermore, out of the 20 patients with triple-negative breast cancer, only 1 (1.3%) received an analog. Conclusions: The study indicates that GnRH analogs usage in breast cancer patients is significantly associated with estrogen receptor positivity. While estrogen receptor status is crucial for determining treatment suitability, GnRH analog utilization was notably low among triple-negative breast cancer patients. This suggests that triple-negative status alone should not preclude GnRH analog use. The findings underscore the need to raise awareness and improve adherence to ovarian suppression recommendations to enhance clinical outcomes and quality of life for breast cancer patients.
Cancer statistics: The United States vs. worldwide.
Authors: Desai Krishna , Baralo Bohdan , Kulkarni Ajinkya , Keshava Vinay E. , Iqbal Sabah , Ali Hassan , Prabhakaran Sivaguha Yadunath , Thirumaran Rajesh
Published: June 2024

e23276

Background: Cancer is now a pandemic worldwide. Although the mortality from cancer is downtrending due to the advent of newer treatment modalities, the global burden of cancer is exponentially increasing due to early detection.Understanding the current cancer demographics can aid in developing strategies to curb the morbidity and mortality from these malignancies. Methods: The data was obtained using 2 databases: GLOBOCAN for global trends, & Surveillance, Epidemiology and End Result database Research Plus Data, 17 Registries, Nov 2022 Sub (2000-2020) for the data in the United States (US). We further stratified SEER data based on incidence, gender & median months of survival (mOS), using the Log-rank test (GraphPad Prism). Results: As per the latest GLOBOCAN analysis, 18,094,716 new cancers (51.63% males,48.36% females) & 9,894,402 deaths (55.49% males, 44.51% females) from cancer occurred, worldwide. The 5 most commonly diagnosed cancers globally were, breast (12.5%), lung (12.2%), colorectal cancer (CRC) (10.7%), prostate (7.8%), & stomach (6%). However, the 5 most common cancers causing mortality globally, were lung (18.2%), CRC (9.5%), liver (8.4%) stomach (7.8%), & breast (6.9%). Whereas, in the US, 2,281,658 new cancers (males 53.75%, females 46.24%) were detected in 2020, & 612,390 deaths (males 52.58%, females 47.41%) occurred from it. The 5 most commonly diagnosed cancers were breast (11.1%), lung (10%), prostate (9.2%), CRC (6.8%), & melanoma (4.2%). Cancer-related mortality was attributed to lung (22.6%), CRC (8.9%), pancreas (7.8%), breast (7%), & prostate (5.3%). SEER data analysis for cancer mortality in the US is listed below in Table 1. Conclusions: Analysis of 2 large databases show that the most common cancers around the world, including the US, are breast, lung, colon & prostate cancers. Breast cancer has the highest incidence, but lung cancer has the highest mortality worldwide. In the US, Whites are more affected & except breast cancer, males have a greater predeliction for the common cancers. mOS was greater for females over all. This study emphasizes the need for further analysis to introspect if modalities such as next generation sequencing-directed immunotherapy would prove beneficial in increasing overall survival. [Table: see text]
Real-world experience with fostamatinib in patients with immune thrombocytopenia: Results of an observational study (FORTE).
Authors: Goel Ruchika , Azhar Waqas , Numerof Robert P. , Chow Donna , Shah Bhavesh
Published: June 2024

e23289

Background: Immune thrombocytopenia (ITP) is an autoantibody-mediated disease in which platelets are prematurely phagocytosed by Fcg-receptor-bearing macrophages in a spleen tyrosine kinase (SYK)-dependent signaling pathway. Corticosteroids (CS) are used to suppress the immune response, but long-term use carries a heavy burden of toxicity. Subsequent treatments for ITP include fostamatinib, a potent oral SYK inhibitor approved in 2018 based on two randomized, placebo-controlled, phase 3 trials. In trial patients, who received fostamatinib as second-line therapy following CS with or without immunoglobulins (IVIG), 25 of 32 (78%) patients achieved a platelet response of ≥50,000/µL, which was sustained for a median of 83% of treatment days. Here, we report real-world experience with fostamatinib as second-line therapy for ITP from a multi-center, prospective, observational study. Methods: The study (FORTE; NCT04904276) enrolled adult patients with ITP and an insufficient response to prior CS and/or IVIG. Patients were treated according to their clinician’s discretion, and data were collected for up to 12 months at clinic visits. Results: Sixteen patients were enrolled, and 15 were treated. Of the 15, 9 (60%) were female and the median age was 48 years (range, 20-92). 12 (80%) patients had prior CS and 6 (40%) prior IVIG. 7 (47%) patients completed the study and 8 discontinued treatment due to adverse events (4), lack of efficacy (2), and patient decision (2). After initiation of fostamatinib, 93% (14/15) of patients achieved ≥1 platelet count ≥50,000/μL. Median platelet count increased over time from 43,000/μL (IQR 19,000-105,000) at baseline to 167,000/μL (IQR 96,000-180,000) at Month 12. The median cumulative duration of elevated platelet count was 32 weeks (IQR 6.4-49.4). Concomitant CS were used by 7 (47%) patients at baseline, all of whom were able to taper as early as Month 1 and discontinue their dose by Month 3 in 4 patients, Month 6 in 2 patients, and Month 9 in 1 patient. Five patients had ITP-related AEs (4 Grade 1 and 1 Grade 2): gingival bleeding (2), mucosal haemorrhage (2), fatigue (1), contusion (3), headache (1) and epistaxis (1). There were 3 serious AEs in 2 patients: Grade 3 diarrhea in 1 and Grade 2 dyspnea and chills in 1. Overall safety results were consistent with previous studies of fostamatinib. Conclusions: Real world use of fostamatinib as documented in this observational study demonstrated efficacy and safety as second-line therapy for ITP. Fostamatinib allowed successful tapering and discontinuation of CS while maintaining platelet counts above 50,000/μL. Clinical trial information: NCT04904276 .
Mental health prevalence in Brazil: Understanding anxiety and depression in southern Capixaba region.
Authors: Aleixo Sabina B. , Pulido Jose Zago , Parmanhane Narelle , Sartoli Ana Arlete , Siller Ana Paula
Published: June 2024

e23295

Background: The rising significance of mental health issues and psychological distress among cancer patients has prompted an in-depth investigation. In the brazilian context, this crucial aspect remains largely unexplored, with limited available data and insufficient investment in understanding the psychosocial dimensions of cancer care. This study aims to generate brazilian-specific data to facilitate the development and implementation of targeted psychosocial interventions within cancer care. Methods: From August 1, 2023, to December 31, 2023, a random selection of 263 patients at a brazilian cancer center underwent assessment for signs and symptoms of anxiety and depression using the Anxiety and Depression Assessment Scale – HAD. This validated screening scale, comprising 14 Likert-type questions, features two subscales with seven items each to track anxiety and depression symptoms. Severity scores for each subscale range from zero to 21, with higher scores indicating increased anxiety and depression levels. In this study, interviewers assessed the severity of symptoms, employing scales ranging from 0 to 21. Three score levels were identified: mild (0-7), moderate (8-11), and high (12-21). Inclusion criteria encompassed age over 18, residency in the southern region of the State of Espírito Santo, a cancer diagnosis, and active treatment. Exclusion criteria included non-residency in th southern region of th state, lack of cancer diagnosis, and oncohematological treatments. Of the 263 eligible participants, 21 were excluded for not meeting inclusion criteria, and 16 declined to participate, resulting in a final sample of 226 patients. Results: The sample comprised 160 women, with 64.90% diagnosed with breast cancer and 35.10% with other neoplasms. Among the 66 men, 41% had prostate cancer and 59% had other neoplasms. Anxiety levels in women were mild (28%), moderate (24%), and high (48%), while in men, levels were mild (39%), moderate (21%), and high (53%). Depression levels in women were mild (42%), moderate (19%), and high (39%). Notably, six suicide attempts occurred among women before cancer diagnosis, and one occurred after diagnosis. Among men, depression levels were mild (47%), moderate (22%), and high (31%). With no history of attempts of suicide in the men population. Conclusions: The study's robust dataset provides compelling and valid information, unveiling a substantial prevalence of mental disorders within the analyzed populations. It emphatically underscores the critical need for tailored supportive care in addressing the unique psychosocial challenges faced by this demographic. Furthermore, the findings advocate for the urgent implementation of targeted psychosocial support interventions to enhance the overall well-being of individuals navigating the complex terrain of cancer and its associated mental health implications.
Localized GIST in Hispanic population in North and South America.
Authors: Sarre-Lazcano Catherine , Carbajal Berenice , Rothschild Sara , Evans Denisse , Soulé Tomás , Call Jerry , Salas Rodrigo , Calderillo Ruiz German , Hernández Alondra , Luevano Castro Samuel Christopher , Alfaro Goldaracena Alejandro , Sicklick Jason K.
Published: June 2024

e23513

Background: Most studies of gastrointestinal stromal tumors (GIST) focus upon patients in a single country. However, differences in patient presentation, treatment, and outcomes may differ between nations. We sought to compare Hispanic patients with localized GIST treated in North and South America. Methods: We performed a retrospective analysis including all Hispanic GIST patients treated at 3 tertiary referral centers in the United States (US), Mexico (MX) and Argentina (AR), as well as those enrolled by 2 patient advocacy groups in US and MX from 2000-2022. Demographic, clinicopathologic and survival data were collected and compared using Pearson’s chi-square or one-way ANOVA test. Disease-specific survival (DSS) was calculated using the Kaplan-Meier method and compared using the log-rank test. Results: Overall, 1,504 Hispanic patients (54.5% female) were analyzed. Median age at diagnosis was significantly lower in US (48 y) than MX/AR (55/57 y, p = 0.001). Presentation stage varied by country. Localized presentation was more frequent in US/MX (77%/88%) than AR (60%, p = 0.001). In 1,208 patients (80.4%) with localized disease, 97.9% underwent surgical resection. Rates of adjuvant imatinib treatment varied from 82.4%/77.0% in US/MX to 35.6% in AR (p < 0.001). Median duration of adjuvant therapy was longer in US (29 mos; range: 16-48) than MX (12 mos; range: 4-36, p < 0.001). With a median follow up of 44 mos (range: 24-78) for patients presenting with localized GIST, the estimated median DSS was 136 mos (95% CI 104-167), being significantly longer in US (267 mos, 95% CI 95-439, p = 0.02). Conclusions: While most studies of disparities focus on differences between races/ethnicities in a single country, we found that disparities also exist within similar ethnic groups across nations. Underappreciated sociopolitical determinants of health likely lead to differences in presentation, management, and long-term outcomes of Hispanic GIST patients in the Americas. Prospective cooperative studies are needed to better define barriers to care in order to improve patient outcomes in Hispanic GIST patients. [Table: see text]
Identifying intra-abdominal desmoid type fibromatosis mimicking recurrence/metastasis of GISTs using FAPI PET/CT.
Authors: Wu Chunhui , Lin Xiaojie , Wen Fang , Hu Xin , Zeng Yu , Lin Fangzeng , Sun Kaiyu , Cai Shirong , Huang Shaoqing , Zhang Xiangsong , Wang Xiaoyan , Zhang Xinhua
Published: June 2024

e23516

Background: Intra-abdominal desmoid tumor (IADT) can mimic the recurrence/metastases of gastrointestinal stromal tumors (GISTs). However, it is difficult to radiologically differentiate IADT and recurrence/metastases of GISTs. This study aims to investigate the value of 18F fibroblast activation protein inhibitor ( [18F]FAPI-42) PET/CT in identifying intra-abdominal desmoid type fibromatosis mimicking recurrence/metastases of GISTs by comparing it to [18F]FDG PET/CT. Methods: This study retrospectively included a total of 24 patients (12 patients with IADT and 12 patients with recurrent/metastatic GISTs). The differences in [18F]FAPI-42 PET/CT parameters (SUVmax-FAPI and SUVTLR-FAPI ), [18F]FDG PET/CT parameters (SUVmax-FDG and SUVTLR-FDG), SUVfapi/SUVfdg ratio of IADT and GISTs were compared. The difference in PET/CT parameters (SUVmax, SUVTLR) of IADT between FDG PET/CT and FAPI PET/CT were compared. Immunohistochemical verification was performed on IADT lesions of all 12 patients and expression profiles of GEO datasets were analyzed to validate the FAP expression of IADT. Results: Both [18F]FAPI-42 PET/CT parameters, SUVmax-FAPI [8.8 (2.0, 16.0) vs 1.9 (1.0, 6.0), P< 0.001]and SUVTLR-FAPI [7.3 (2.0, 15.8) vs 1.7 (0.5, 6.9), P< 0.001], of IADT was significantly higher than that of GISTs, while there was no statistically significant difference in [18F]FDG PET/CT parameters, SUVmax-FDG and SUVTLR-FDG, between this two group. The ratio (SUVfapi/SUVfdg) of IADT was significantly higher than that of GISTs [3.3 (1.5, 8.0) vs 0.5 (0.1, 3.9), P= 0.001]. The SUVmax and SUVTLR of FAPI PET/CT of IADT were significantly higher than that of FDG PET/CT [8.8 (2.0, 16.0) vs 2.5 (1.1, 6.2), P< 0.001; 7.3 (2.0, 15.8) vs 0.9 (0.4, 2.7), P< 0.001; respectively]. FAP expression was found to be expressed in all the examined tissues and highly expressed in most of them. GEO database analysis shows that the FAP gene expression in DT is significantly higher than that in GISTs. Conclusions: FAPI PET/CT is a promising method in differentiating IADT from recurrence/metastases of GISTs compared with FDG PET/CT since FAP expression in DT is significantly higher than that in GISTs.
US-China relations and Greece’s regional role as a bridge between them in the Eastern Mediterranean
Authors: Καφεστίδης Στυλιανός
Published: June 2024

Η διατριβή καλύπτει τους γεωπολιτικούς ανταγωνισμούς στην Ανατολική Μεσόγειο, τον ρόλο των διαφόρων εμπλεκόμενων παραγόντων και τις επιπτώσεις για τήνΕλλάδα. Το συγκεκριμένο ερευνητικό θέμα επικεντρώνεται στην αλληλεπίδραση και τον ανταγωνισμό μεταξύ των ΗΠΑ και της Κίνας στην Ανατολική Μεσόγειο καθώς επίσης και τόν εξωτερικό πολιτικό ρόλο της Ελλάδας σε αυτό το στρατηγικό παιχνίδι εξουσίας. Η παρούσα διατριβή επιχειρεί να εξετάσει τις προβολές των αμερικανικών και κινεζικών συμφερόντων στην Ανατολή Μεσόγειο καθώς επίσης και τον περιφερειακό ρόλο της Ελλάδας, όντως κράτους μέλους της ΕΕ, ως γέφυρα επικοινωνίας μεταξύ τους. Το πρώτο κεφάλαιο παρέχει μια επισκόπηση του γενικούπλαισίου της πολιτικής της Ανατολικής Μεσογείου με ιδιαίτερη έμφαση στις αντιλήψεις και τη γεωπολιτική συνάφεια της περιοχής. Κύριοι παίκτες και ενδιαφερόμενοι φορείςεξετάζονται, καθώς και οι διασταυρώσεις των ενδιαφερόντων και των αλληλεπιδράσεων τους. Το δεύτερο κεφάλαιο εξετάζει κριτικά τα ανταγωνιστικά συμφέροντα των ΗΠΑ καιτής Κίνας στην Ανατολική Μεσόγειο καθώς επίσης και τής επιπτώσεις που έχει αυτός ο ανταγωνισμός για την Ελλάδα. Αξιολογούνται διαφορετικές επιλογές πολιτικής για την Ελλάδα. Το τρίτο κεφάλαιο περιλαμβάνει την εμπειρική μελέτη που βασίζεται σε δομημένες συνεντεύξεις με υπεύθυνους χάραξης πολιτικής, επιχειρηματίες, ΜΚΟ και ακαδημαϊκό κόσμο. Οι απαντήσεις των ερωτηθέντων δίνουν την εις βάθος άποψη του τρόπου με τον οποίο γίνεται αντιληπτός ο προσανατολισμός και η πορεία της ελληνικής εξωτερικής πολιτικής σε σχέση με τους στρατηγικούς στόχους των ΗΠΑ και της Κίνας, πρωτίστως. Η Διεξαγωγή και η ανάλυση αυτής της έρευνας είναι μια απο της βασικές συνεισφορές αυτής της διατριβής.
Empatía con el paciente en médicos especialistas que trabajan en un Hospital de Cuenca, Ecuador.
Authors: Díaz-Narváez Víctor Patricio , Davila Pontón Yolanda , Marín Dávila Mabel , Carbone Paz Bianca , Reyes Reyes Alejandro , Calzadilla Núñez Aracelis
Published: June 2024

Introducción: La empatía es uno de los componentes de la estructura de la humanización en la atención de los pacientes. Los médicos especialistas deben tener altos niveles de empatía. Objetivo. El objetivo del presente trabajo es describir los niveles de empatía en médicos que trabajan en un hospital de alta complejidad y explorar diferencias entre las especialidades estudiadas.  Métodos:  Muestra por conveniencia de 237 médicos que representa el 53,55 % del total poblacional (N=443). La empatía fue medida mediante la Escala de Empatía para Profesionales de la Salud. Se realizó análisis factorial confirmatorio y análisis multigrupo para examinar la invarianza del modelo entre los sexos y análisis de confiabilidad (α de Cronbach, coeficiente de correlación intraclase y ω de McDonald). Resultados: La especialidad de pediatría tuvo los niveles más altos en la empatía general y en las dimensiones Cuidado con compasión y “Caminando en los zapatos del paciente”, no así en la dimensión Toma de perspectiva donde presenta niveles semejantes a las especialidades de anestesiología, medicina crítica y terapia intensiva, y ginecología. Conclusión: Los valores de la empatía y los valores en las subescalas Cuidado con compasión y “Caminando en los zapatos del paciente” fueron (en valores absolutos, pero no estadísticos) mayores en la especialidad de Pediatría. En la subescala Toma de perspectiva, las especialidades de Pediatría, Anestesiología, Cirugía y Clínica se observaron puntuaciones prácticamente iguales. Se requieren otros estudios que permita arribar a una explicación que permita entender por qué algunas especialidades tienen valores de empatía mayores que otras.
Cuidado Centrado en la Persona y autonomía en la atención clínica de usuarios que viven con multimorbilidad
Authors: Dois Angelina
Published: June 2024

Objetivo: Promover autonomía significa transitar desde un modelo paternalista hacia uno que posicione en un rol activo a las personas durante el encuentro clínico, con participación en la toma de decisiones relativas al cuidado de su salud. Este manuscrito describe la percepción de usuarios que viven con multimorbilidad respecto del ejercicio de su autonomía durante la atención clínica. Método: Estudio de caso cualitativo en usuarios con multimorbilidad atendidos en un Centro de Salud Familiar de Santiago, Chile. Se realizó análisis de contenido según Krippendorf. Resultados: La muestra quedó conformada por 19 participantes adultos con un promedio de 2,7 condiciones crónicas de salud. Del análisis de contenido de las entrevistas emergen tres categorías: a) Significado atribuido por los usuarios a la autonomía en la atención de salud, b) Elementos que debe considerar una atención en salud que respete la autonomía del usuario y c) Participación durante la atención clínica. Conclusiones: Frente al aumento de las condiciones crónicas de salud imperativo repensar la forma de brindar atención de salud, relevando el valor de la participación usuaria a través de la toma de decisiones compartida como expresión de respeto de su autonomía y una forma de fomentar el cuidado centrado en las personas.
Kooperatives Wirtschaften in der Zivilgesellschaft
Authors: Blome-Drees Johannes , Degens Philipp , Flieger Burghard , Franke Greta , Lapschieß Lukas , Lautermann Christian , Moldenhauer Joschka , Pentzien Jonas , Young Carla
Published: June 2024

Sozialunternehmen, Genossenschaften, Bürgergesellschaften und Vereine leisten einen wichtigen Beitrag zur Gestaltung einer gemeinwohlorientierten Versorgung in allen Lebensbereichen. Der Band untersucht anhand von Fallstudien zu Bürgerenergiegenossenschaften, solidarischer Landwirtschaft, Seniorengenossenschaften sowie Plattform-Kooperativismus, wie derartige Organisationen wirtschaften. Ein besonderer Schwerpunkt liegt dabei auf der vergleichenden empirischen Analyse der Verbundstrukturen in den unterschiedlichen Versorgungsbereichen. Im Zuge dessen wird deutlich, wie kooperatives Wirtschaften in der Zivilgesellschaft funktioniert und inwiefern hierdurch Gemeinwohl gefördert wird. https://creativecommons.org/licenses/by-nc-nd/4.0/
A stepwise transformation: description and outcome of perioperative procedures in patients receiving a total knee arthroplasty
Authors: van Houtert Wim F. C. , Strijbos Daniël O. , Bimmel Richard , Krijnen Wim P. , Jager Jelmer , van Meeteren Nico L. U. , van der Sluis Geert
Published: June 2024

Aims

To investigate the impact of consecutive perioperative care transitions on in-hospital recovery of patients who had primary total knee arthroplasty (TKA) over an 11-year period.

Methods

This observational cohort study used electronic health record data from all patients undergoing preoperative screening for primary TKA at a Northern Netherlands hospital between 2009 and 2020. In this timeframe, three perioperative care transitions were divided into four periods: Baseline care (Joint Care, n = 171; May 2009 to August 2010), Function-tailored (n = 404; September 2010 to October 2013), Fast-track (n = 721; November 2013 to May 2018), and Prehabilitation (n = 601; June 2018 to December 2020). In-hospital recovery was measured using inpatient recovery of activities (IROA), length of stay (LOS), and discharge to preoperative living situation (PLS). Multivariable regression models were used to analyze the impact of each perioperative care transition on in-hospital recovery.

Results

The four periods analyzed involved 1,853 patients (65.9% female (1,221/1,853); mean age 70.1 years (SD 9.0)). IROA improved significantly with each transition: Function-tailored (0.9 days; p < 0.001 (95% confidence interval (CI) -0.32 to -0.15)), Fast-track (0.6 days; p < 0.001 (95% CI -0.25 to -0.16)), and Prehabilitation (0.4 days; p < 0.001 (95% CI -0.18 to -0.10)). LOS decreased significantly in Function-tailored (1.1 days; p = 0.001 (95% CI -0.30 to -0.06)), Fast-track (0.6 days; p < 0.001 (95% CI -0.21 to -0.05)), and Prehabilitation (0.6 days; p < 0.001 (95%CI -0.27 to -0.11)). Discharge to PLS increased in Function-tailored (77%), Fast-track (91.6%), and Prehabilitation (92.6%). Post-hoc analysis indicated a significant increase after the transition to the Fast-track period (p < 0.001 (95% CI 3.19 to 8.00)).

Conclusion

This study highlights the positive impact of different perioperative care procedures on in-hospital recovery of patients undergoing primary TKA. Assessing functional recovery, LOS, and discharge towards PLS consistently, provides hospitals with valuable insights into postoperative recovery. This can potentially aid planning and identifying areas for targeted improvements to optimize patient outcomes.

Cite this article: Bone Joint J 2024;106-B(6):573–581.
Contact states with femoral cortical bone and periprosthetic bone mineral density changes differ between traditional and newly introduced fully hydroxyapatite-coated stems
Authors: Ohyama Yohei , Minoda Yukihide , Masuda Sho , Sugama Ryo , Ohta Yoichi , Nakamura Hiroaki
Published: June 2024

Aims

The aim of this study was to compare the pattern of initial fixation and changes in periprosthetic bone mineral density (BMD) between patients who underwent total hip arthroplasty (THA) using a traditional fully hydroxyapatite (HA)-coated stem (T-HA group) and those with a newly introduced fully HA-coated stem (N-HA group).

Methods

The study included 36 patients with T-HA stems and 30 with N-HA stems. Dual-energy X-ray absorptiometry was used to measure the change in periprosthetic BMD, one and two years postoperatively. The 3D contact between the stem and femoral cortical bone was evaluated using a density-mapping system, and clinical assessment, including patient-reported outcome measurements, was recorded.

Results

There were significantly larger contact areas in Gruen zones 3, 5, and 6 in the N-HA group than in the T-HA group. At two years postoperatively, there was a significant decrease in BMD around the proximal-medial femur (zone 6) in the N-HA group and a significant increase in the T-HA group. BMD changes in both groups correlated with BMI or preoperative lumbar BMD rather than with the extent of contact with the femoral cortical bone.

Conclusion

The N-HA-coated stem showed a significantly larger contact area, indicating a distal fixation pattern, compared with the traditional fully HA-coated stem. The T-HA-coated stem showed better preservation of periprosthetic BMD, two years postoperatively. Surgeons should consider these patterns of fixation and differences in BMD when selecting fully HA-coated stems for THA, to improve the long-term outcomes.

Cite this article: Bone Joint J 2024;106-B(6):548–554.
Re-revision and mortality rate following revision total hip arthroplasty for infection
Authors: Resl Martin , Becker Luis , Steinbrück Arnd , Wu Yinan , Perka Carsten
Published: June 2024

Aims

This study compares the re-revision rate and mortality following septic and aseptic revision hip arthroplasty (rTHA) in registry data, and compares the outcomes to previously reported data.

Methods

This is an observational cohort study using data from the German Arthroplasty Registry (EPRD). A total of 17,842 rTHAs were included, and the rates and cumulative incidence of hip re-revision and mortality following septic and aseptic rTHA were analyzed with seven-year follow-up. The Kaplan-Meier estimates were used to determine the re-revision rate and cumulative probability of mortality following rTHA.

Results

The re-revision rate within one year after septic rTHA was 30%, and after seven years was 34%. The cumulative mortality within the first year after septic rTHA was 14%, and within seven years was 40%. After multiple previous hip revisions, the re-revision rate rose to over 40% in septic rTHA. The first six months were identified as the most critical period for the re-revision for septic rTHA.

Conclusion

The risk re-revision and reinfection after septic rTHA was almost four times higher, as recorded in the ERPD, when compared to previous meta-analysis. We conclude that it is currently not possible to assume the data from single studies and meta-analysis reflects the outcomes in the ‘real world’. Data presented in meta-analyses and from specialist single-centre studies do not reflect the generality of outcomes as recorded in the ERPD. The highest re-revision rates and mortality are seen in the first six months postoperatively. The optimization of perioperative care through the development of a network of high-volume specialist hospitals is likely to lead to improved outcomes for patients undergoing rTHA, especially if associated with infection.

Cite this article: Bone Joint J 2024;106-B(6):565–572.
June 2024 Pulmonary Case of the Month: A Pneumo-Colic Association
Authors:   Mayo Clinic Arizona, Phoenix, AZ USA, Wesselius Lewis
Published: June 2024

No abstract available. Article truncated after 150 words. History of Present Illness: The patient is a 57-year-old woman who presented to the emergency department with increasing cough and shortness of breath over several days. She has a history of ulcerative colitis complicated by toxic megacolon with subsequent colectomy. Past Medical History, Family History and Social History • Ulcerative colitis with history of toxic megacolon (4 years prior), s/p total colectomy • History of recent respiratory failure thought secondary to ustekinumab (Stelara). The respiratory failure responded well to steroid therapy. • She has a history of latent Tb treated with rifampin • Anxiety Medications • Clonazepam 1.0 mg daily at bedtime • Gabapentin 300 mg TID • Pantoprazole 40 mg BID • Prednisone 5 mg daily Physical Examination • Mild-moderate respiratory distress • Afebrile. SpO2 87% on room air. Oxygen saturation 94% on 2 lpm supplemental oxygen. • Chest: crackles noted at left base • Cardiovascular: regular rhythm, no murmur • Extremities: scarring and erythema on both ankles consistent with resolving pyoderma …
The Blue Beaded Dress in the Works of Susan Power
Authors: Majhor Samantha
Published: June 2024

Abstract: This article combines archival research at The Field Museum of Natural History in Chicago with references to a blue beaded Dakota dress that Susan Power makes in both her fictional novel The Grass Dancer and her nonfiction essay "Museum Indians." In a close reading of Power's writing, the author traced the blue beaded dress as it moves from family history to the museum and, finally, ends up dancing on the moon. Power's novel articulates a Dakota object ontology that thwarts traditional understandings of space-time in order to strengthen and reinforce kinship ties. Power's depictions of the dress defy the typical view of such objects as stagnant, dependent entities, and Majhor argues that Power offers a view of Dakota materialism that positions the dress as a participatory and per-formative object-being. Taking Power's works together with an analysis Field Museum's Dakota holdings, the author argues that her writings offer imaginative liberation of object-beings like the dress and, ultimately, call for the material liberation and repatriation of such objects.
"Leaves on the Trees": Ecological Placemaking and Dakota Identity in Zitkala-Ša and Elizabeth Cook-Lynn
Authors: Henkle Alex
Published: June 2024

Abstract: This article draws a parallel between Zitkala-Ša's Atlantic Monthly trilogy and Elizabeth Cook-Lynn's Aurelia trilogy to demonstrate the methods of placemaking and ecological description that continue an oral narrative tradition, preserving placemarkers in land narrative and demonstrating Dakota methods of survivance and resistance to settler colonial ideology. An ecocritical consideration of Native relationships to placemaking paired with Gerald Vizenor's theories of ironic subversion demonstrates an active landscape essential to the maintenance of Dakota modes of signification and the use of narrative as a decolonial tool. Both authors use the oral tradition (as defined by Waziyatawin, formerly Angela Wilson) to demonstrate the importance of memory and preservation of Oceti Sakowin discourse, drawing on natural imagery of rivers to refer to birth and creation. By demonstrating the power of narrative as a tool for decolonization and resistance, this article underscores the continued importance of preserving oral traditions as a model for preserving Dakota epistemology.
New Developments in Native American Catholicism: The Opening of Black Elk’s Canonization Cause
Authors: Rigal-Cellard Bernadette
Published: June 2024

ABSTRACT: This article addresses issues raised by the 2017 opening of the canonization process for Black Elk, the voice of the celebrated Native American autobiography, Black Elk Speaks (1932). Though it was begun by his own family to recognize his merit as a Catholic catechist, some observers criticize the project as a ploy by the Church to erase his Lakota identity. The debate centers around the inculturation initiative begun by the Catholic Church in the 1960s that evolved to include the current reconciliation policy: by allowing Indigenous Catholics to bring into the Church their own cultural traditions, Rome sought to retain them when the call to leave grew stronger in the wake of decolonization. It is likely that the second stage in the canonization process—that of Venerable, now being discussed in Rome—will soon succeed. (The first stage of the process is being declared a Servant of God at the diocesan level.) Allowing Black Elk’s future sainthood would substantiate the good faith of the Catholic Church in its declarations on reconciliation with Indigenous Americans.
A Story Thrice Told: Variations on the Theme of Bruges-la-Morte
Authors: Claussen Alexander
Published: June 2024

ABSTRACT: Georges Rodenbach's Bruges-la-Morte (1892), frequently studied for its Symbolist elements, is here presented in a new light. By tracing the production and reception history of the narrative (as feuilleton , novel, and play), this article demonstrates how Rodenbach adapts the central storyline to fit generic conventions and respond to audience expectations. Studying the tripartite production history demonstrates the multiplicity of readings possible from a single narrative. It also serves as an example of how late nineteenth century authors reworked existing texts for new audiences, and a reminder of the fragility of what is considered the "final" version of a story. Abstract: Bruges-la-Morte (1892) de Georges Rodenbach est souvent considéré comme le roman symboliste par excellence. Mais ce qui est vrai pour le roman ne l'est pas pour le récit. Nous proposons une relecture du récit sur la base de trois versions publiées: roman-feuilleton, roman et pièce de théâtre. Dans chacune, Rodenbach a modifié la forme et le fond du récit pour répondre aux attentes des différents publics. Cette étude retrace ces modifications. Elle montre comment un auteur de la fin du XIXe siècle a pu réutiliser un récit sans le répéter, et elle nous rappelle le danger de considérer une de ces versions comme "définitive."
Aproximación teórica a los entornos innovadores de aprendizaje inclusivos
Authors: Granda-Piñán Amelia R. , López Company José Vicente , Taberner Perales Encarna , Vecino Ramos Sonia
Published: June 2024

El presente artículo constituye una aproximación teórica al uso de los Entornos Innovadores de Aprendizaje (EIA) como contextos educativos inclusivos en la educación obligatoria. Los EIA combinan un diseño innovador del espacio y prácticas educativas innovadoras para favorecer la inclusión educativa y responder a las necesidades del alumnado. Se destaca la importancia del Diseño Universal para el Aprendizaje (DUA) y el Diseño Universal para el Aprendizaje Accesible (DUA-A) como teorías inclusivas que se pueden aplicar en estos entornos, afianzando de esta forma la primera idea. A modo de conclusión y como aportación novedosa se proponen una serie de características que deben tener estos EIA para diseñarse correctamente y facilitar la inclusión de todo el alumnado.
Análise de Escalabilidade de Método de Exploração e Mapeamento Bioinspirado no Formato das colmeias de Abelha
Authors: De Campo Monteiro Gomes Bruno , Aurélio Wehrmeister Marco
Published: June 2024

ABSTRACTIn situations of catastrophes or accidents that cause a high riskof life for people and also for the rescue team, the use of multipleUnmanned Aerial Vehicles (UAV) can help a lot in scenarioswhere the expected time of mapping and exploration is very small,so the faster the internal environment is known and mapped, thebetter the rescue strategy will be and the more likely the lives willbe saved. The help of multiple UAVs can be very advantageousin the race against time for data collection of the scenario to berescued, in indoor and unknown environments, in which navigationsystems such as global positioning (GPS) are not a possiblesolution. However, a proposal was created to be applied in thesecases, which uses a bioinspired method with multiple UAV for explorationand mapping, so that each autonomous UAV starts theprocess of territory exploration inspiringif in the hexagonal shapeof honeycombs of bees. However, this method used a maximum ofthree UAV due to the technological limitations of the simulationenvironment. Therefore, the purpose of this work was to create asimulation environment capable of working with dozens of UAVat the same time, so that the scalability of this method can be evaluated,taking into account the metrics of the original work andadding more and more UAV to the scenarios. It was observed thatthe method can be scalable up to a certain number of UAVs, dependingon the area of the environment, so that when adding moreUAVs, the exploration time does not decrease, sometimes increases,due to increased trac and the blockages generated.
Meninas que Influenciam: A Construção de um Livro para Apoiar Meninas na Área da Computação
Authors: Sartori Andreza , Zózimo Antunes Larissa , P. de Araújo Kohler Luciana , Capobianco Lopes Mauricio , Zucco Fabricia , Lerner Ribeiro Leandro
Published: June 2024

ABSTRACTThroughout history, women have played significant roles inhuman achievements. However, the current lack of femalerepresentation in the field of computing remains apparent. Inresponse, the extension project Meninas Digitais Vale do Itajaíprovides workshops for girls in their final years of elementary andhigh school, with the aim of inspiring them to pursue careers incomputing. This work details the conceptualization of a booknamed “Girls Who Influence” which originated from a workshopheld with girls in 2019. It also covers the illustration, layout, andlaunch process of this book. Moreover, it discusses how theseefforts contributed to an expanded project visibility with localcompanies and, as a result, broadened the project's actions andreach to a wider audience.
Uma extensão para o VSCode que utiliza o ChatGPT como ferramenta de apoio ao desenvolvimento de software seguro
Authors: Ribeiro de Almeida Neto Mustafa , Mori Lazarin Nilson
Published: June 2024

ABSTRACTThis paper proposes the adoption of Generative Artificial Intelligence(GAI) in order to reduce vulnerabilities on the software developmentprocess. To analyze this approach, we present a VSCode’sextension for the ChatGPT. Furthermore, we proceed a qualitativeevaluation of the GAI’s suggests to fix various vulnerable codes.The observed results suggest that this approach can be promising,bringing certainty to developers when dealing with softwaresecurity issues.
Meninas na Computação -Relato de Experiência do Projeto Meninas Digitais do IFSULDEMINAS Campus Machado
Authors: Moreira Ferreira Emily , Silva Souza Sabrina , Nubia M. Ferreira Dayane , Eloy Franco Matheus , A. G. Dias Daniela
Published: June 2024

ABSTRACTThe Assisted Research and Extension Group Digital Girls of the Federal Institute of Southern Minas Gerais, located in Machado, has as its main objective bring girls closer to the area of technology area, encouraging entry and preventing dropouts from higher education technology courses. This reports the main actions of the project, highlighting the relevance of the Santos Dumont research call "Program to increase the participation of students from Machado Campus in competitions and the number of girls in higher education courses and the completion rate of courses related to and completion rates of computer science-related courses", as a driving force behind the study group and sharing experiences, emphasizing the importance of research and extension initiatives for female participation in the technology.
Gamificação no ensino de empreendedorismo: Uma revisão sistemática da literatura e agenda de pesquisa futura
Authors: Soares Ana Maria Jeronimo , Melo Felipe Luiz Neves Bezerra de , Dantas Saulo de Tarso Alves , Silva Marcos Paulo da , Genuino Shirley Luanna Vieira Peixoto
Published: June 2024

Objetivo: Este estudo busca compreender como pesquisadores têm abordado a gamificação no ensino de empreendedorismo e, a partir dessa análise, propor direções para pesquisas futuras por meio da sistematização de Teorias, Contextos, Características e Metodologias (Framework TCCM). Metodologia: O protocolo Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) foi utilizado para a revisão sistemática em oito bases de pesquisa (Web of Science, Science Direct, Scopus, Springer, Emerald, Wiley, Sage e Taylor & Francis). Foram incluídos 33 estudos empíricos, publicados entre 2017 e 2022. Principais Resultados: A maioria das pesquisas não explorou uma variedade de teorias existentes, como a Teoria do Comportamento Planejado. Ademais, os trabalhos se concentram no ensino superior, havendo uma lacuna no contexto do ensino fundamental e médio. Sugere-se que as amostras sejam balanceadas por gênero, análises com métodos mistos, estudos experimentais e longitudinais. Contribuições: O estudo contribui com a literatura ao compilar as principais abordagens adotadas na educação empreendedora gamificada. Ademais, propõe uma agenda de pesquisa a partir das lacunas na literatura. Relevância e originalidade: a pesquisa adota uma abordagem conjunta dos protocolos PRISMA e TCCM, avançando além da mera descrição de resultados, com o intento de fundamentar uma agenda de pesquisa propositiva para a comunidade acadêmica de empreendedorismo. Contribuições gerenciais e sociais: a identificação de melhores práticas para a aplicação da gamificação no ensino de empreendedorismo - o design de jogos e a seleção de objetivos de aprendizagem - fornece insights para os educadores, formuladores de políticas públicas, instituições de fomento ao empreendedorismo e programas corporativos.
Gamification in entrepreneurship education: A systematic literature review and future research agenda
Authors: Soares Ana Maria Jeronimo , Melo Felipe Luiz Neves Bezerra de , Genuino Saulo de Tarso Alves , Silva Marcos Paulo da , Genuino Shirley Luanna Vieira Peixoto
Published: June 2024

Objective: This study aims to understand how researchers have approached gamification in entrepreneurship education and, based on this analysis, propose directions for future research through the systematization of Theories, Contexts, Characteristics, and Methodologies (TCCM Framework). Methodology: The Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) protocol was used for the systematic review in eight research databases (Web of Science, Science Direct, Scopus, Springer, Emerald, Wiley, Sage, and Taylor & Francis). 33 empirical studies published between 2017 and 2022 were included. Main results: Most of the research did not explore a variety of existing theories, such as the Theory of Planned Behavior. Additionally, the works focus on higher education, with a gap in the context of primary and secondary education. It is suggested that samples be gender-balanced, mixed-method analyses, experimental and longitudinal studies. Contributions: The study contributes to the literature by compiling the main approaches adopted in gamified entrepreneurship education. Additionally, it proposes a research agenda based on gaps in the literature. Relevance and originality: This research adopts a joint approach of the PRISMA and TCCM protocols, advancing beyond the mere description of results, with the intent of grounding a proactive research agenda for the entrepreneurship academic community. Managerial and social contributions: The identification of best practices for the application of gamification in entrepreneurship education - game design and selection of learning objectives - provides insights for educators, policymakers, entrepreneurship support institutions, and corporate programs.
Assistência da Enfermagem no Tratamento e Prevenção da Sífilis em Jovens: Uma Revisão Integrativa
Authors: Santos Iarno Gonçalves Freitas , Coelho Viviane Amaral Toledo , Nascimento Ednardo de Souza , Coelho Thomaz , Bigatello Creonice Santos , Araújo Luanna Botelho Souto de , Alves Virginia Torres , Lopes Lívia Alves Rezende
Published: June 2024

A sífilis é uma doença infecciosa crônica com prevalência descrita desde o século XV. Embora seu agente etiológico e também as formas de tratamento sejam amplamente conhecidas, a sífilis ainda é um grande problema de saúde pública em todo o mundo e está afetando cada vez mais os jovens. O estudo teve como objetivo realizar uma revisão integrativa da literatura sobre a assistência da enfermagem no tratamento e prevenção da sífilis em jovens. Trata-se de uma revisão bibliográfica do método revisão integrativa da literatura à luz de autores pertinentes a temática, tendo em vista a importância que o enfermeiro exerce na prevenção e ao controle de infecções sexualmente transmissíveis, em especial, na Sífilis. As buscas foram realizadas em portais como: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), SciELO. Foram coletados e analisados dados referentes aos anos de 2000 a 2020. Os dados que integram o espectro de assuntos relacionado ao tema: atuação da assistência da enfermagem no tratamento e prevenção da sífilis em jovens. Os descritores utilizados foram: “assistência de enfermagem” foram encontrados 6 artigos; “enfermagem no tratamento” e “prevenção da sífilis em jovens” 4 artigos foram encontrados; “Sífilis” foram encontrados 40 artigos. Diante dos resultados obtidos no estudo por meio da estratégia de busca, os autores delinearam variáveis para melhor descrever as evidências encontradas na pesquisa. Conclui-se que o papel do enfermeiro não se limita apenas à prevenção, mas também ao manejo das ISTs. As graves consequências das ISTs para a saúde podem ocorrer anos após a infecção, prejudicando ainda mais a capacidade dos jovens de conectar causa e efeito. Os enfermeiros que estão comprometidos com os desafios de atender jovens para prevenir DSTs, podem ajudar fornecendo cuidados confidenciais e promovendo a saúde sexual.
Abordagem temática na Educação Ambiental
Authors: Lemos Bergamaschi Christyan , De Conte Carvalho de Alencar Isabel , Ferreira Lobino Maria das Graças
Published: June 2024

Realizamos uma revisão de literatura, por meio de um mapeamento sistemático, para analisar as tendências nacionais e internacionais expressas em artigos, dissertações e teses sobre a abordagem temática freiriana na Educação Ambiental de 2011 a 2021. Constatamos que muitos trabalhos usam os termos “abordagem temática” ou “tema gerador” como ponto de partida para suas intervenções, porém sem considerar os pressupostos teórico-metodológicos de Paulo Freire, assim, estes foram excluídos do corpus. As pesquisas têm tendências a serem participativas, principalmente por pesquisa-ação, com intervenções realizadas em espaços formais, majoritariamente, e não formais, além de discussões e proposições de (re)estruturações curriculares. A abordagem CTS/CTSA, formação de professores e uso de tecnologias aparecem como possibilidades de se trabalhar a abordagem temática dentro do contexto da Educação Ambiental.