bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemanfaatan internet untuk edukasi gizi bagi penyandang diabetes mellitus
Authors: Isaura Emyr Reisha , Probosuseno Probosuseno , Rialihanto Muhammad Primiaji
Published: March 2019

Background: The pattern of disease incidence has changed nowadays as indicated from epidemiological transition, from infection to noninfection diseases or noncommunicable diseases. The quantity of diabetes mellitus (DM) patients in Indonesia is increasing every year. Integrated management of DM requires synergy from different parties. According to Act No. 36/2009 on Health, article 17 paragraph 1 states that the government is responsible for the availability of access to information, education, and health facilities to improve and maintain highest health status.Objective: The study aimed to analyze the utilization of the internet or online media in the dissemination of recommended eating pattern and physical activities of DM patients as prevention against complication.Method: The study used cross-sectional design and was carried out in January 2013 at Surabaya Municipality. It used e-survey, with secondary data from hospitals at Surabaya Municipality. Samples were DM patients of 20-50 years old registered in hospitals and agreed with informed consent. Samples were taken purposively involving 66 respondents.Results: There was a difference in eating pattern among DM patients utilizing online and those using nononline media (OR=3.33; CI 95%=1.06-10.43; p=0.03); and in physical activities (OR=0.09; CI 95%=0.01-0.75; p=0.008).Conclusion: The utilization of online media affected eating pattern and physical activity pattern in DM patient as much as 3.33 times and 0.09 times greater than in those not using online media in looking for communication, information, and education resources in supporting prevention against DM complication. Thus online media could be one of the effective and efficient methods for the delivery of communication, information, and education for DM patients by health staff.
Paparan iklan televisi terhadap pemilihan makanan dan asupan energi pada anak
Authors: Subardjo Yovita Puri , Sudargo Toto , Julia Madarina
Published: March 2019

Background: Obesity in school children is the problem of world epidemics of which its prevalence increases sharply. Food marketing through television is presumed to be one of the causing factors.Objective: To find out whether exposure to food and beverage ads through television influenced food choice and intake in children and whether its effect varied in different nutrition status.Method: The study was an experiment involving 2 experiment groups. The first group was exposed to film with food and beverage ads; the second with ads excluding foods and beverages. The children were given 8 advertised foods and drinks and 4 natural foods. The assessment was then made on energy intake and food choice. The population of the study was elementary school children at Yogyakarta Municipality and samples were selected through multi-stage random sampling. Data were analyzed descriptively and through correlation analysis.Results: Children exposed to food and beverage television ads had higher energy intake (262.7±99.7 kcal) from those on ads than children not exposed to ads (233.7±103.3 kcal), and chose more from those on ads (4.7±1.7) than children not exposed to ads (4.2±1.7). Children with normal nutrition status were influenced more by food and beverage television ads than children with over nourished and undernourished nutrition status.Conclusion: Exposure to food and beverage television ads influenced food choice and energy intake in children.
Keefektifan ekstra putih telur terhadap peningkatan albumin dan penurunan IL-1β pada pasien tuberkulosis dengan hipoalbuminemia
Authors: Prastowo Agus , Lestariana Wiryatun , Nurdjanah Siti , Sutomo Retno
Published: March 2019

Background: Tuberculosis (TB) is world health problem which still needs attention. Recently, Indonesia ranks the third in TB prevalence after India and China. Research revealed that albumin decreases significantly in TB patients, due to lack of nutritious intakes such as low-calorie intake, anorexia, increased catabolism, enteropathy and acute protein reaction. Low albumin was associated with increased IL-1β and cytokines inflammation in TB patient. Albumin had a very important role in the body and white egg known as a good quality source of protein.Objective: To assess the effect of white egg supplementation in TB patient towards the level of albumin and the level of IL-1β.Method: A single-blind randomized controlled trial was conducted with 75 patient selected for the study and divided to 37 patient as the study group and 38 as a control group. Both groups received high energy high protein diet, while the study group received, additionally, an oral egg white-based on formula calculation Baxter for 14 days. Control group received, additionally, an extra soybean curd and mungbean powder. Albumin and IL-1β were checked before and after the intervention. Data is analyzed by using Mann-Whitney.Results: Research results show that average albumin pre-intervention in the study group was 2.82 g/dL and control group was 2.85 g/dL. Average albumin difference in the study group was 3.47 g/dL and control group was 2.81 g/dL. Bivariate analysis results show significant of increasing albumin between study group and control group (p<0.05). Research results show average IL-1β pre-intervention difference in study group (0.9 pg/mL) and control group (0.67 pg/mL). The average IL-1β difference in the study group was -0.39 pg/mL and control group was 0.76 pg/mL. Bivariate analysis results show a significant difference of IL-1β depletion between study group and control group (p<0.05).Conclusion: Egg white increase albumin level and IL-1β depletion in tuberculosis patients effectively.
Asupan zink dan magnesium makanan dengan disfungsi ereksi pada penderita sindrom metabolik
Authors: Saraheni Saraheni , Pramantara I Dewa Putu , Astuti Herni
Published: March 2019

Background: Metabolic syndrome (MetS) is a disease of disorder of lipid and nonlipid metabolism. The West of Scotland Coronary Prevention Study found that men with MetS had probability 3.7 dysfunctions of erection (ED) by using International Index of Erectile Function (IIEF). Patient with heart disease had the risk 2 times to get ED, hypertension was 1.5-2 times, DM was 3-4 times, depression was 2-3.5 times, testosterone deficiency syndrome (TDS) was 1.5-2 times, and high cholesterol was 4 times. The nutrient deficiency of zinc (Zn) and magnesium (Mg) was suspected being the main component which had a role in resisting a sexuality growth and maturation process.Objective: Knowing the correlation of Zn and Mg feeding with erection dysfunction in MetS person.Method: This study was observational analytic study, with case-control design in the patient aged 30-60 years old. The respondent in this study was people with MetS according to WHO criterion. There was 82 patient divided into two groups, consist of 41 cases of MetS and ED, 41 cases with the normal patient. The data collected by interview, laboratory assessment and anthropometric measurement. The data analysis using univariate, bivariate and multivariate analysis using multiple logistic regression.Results: There was significant correlation between Zn feeding and ED (OR=7.15; 95% Cl=1.47-34.71; p=0.007) and there was significant correlation between Mg feeding with ED (OR=3.34; 95% Cl=1.07-10.4; p=0.033). The end result of the multivariate analysis showed the risk variable to the ED event, that was Zn feeding with OR=15.41. If the intake of Zn accompanied with risk factors associated as a cause of ED, multivariate analysis showed HbA1c’s degree with OR=12.57; triglyceride (OR=10.47); blood pressure (OR=5.82); and abdominal obesity (OR=6.94). The result shows that these risk factors can aggravate or anticipate the onset of dysfunction erection beside low Zn intake.Conclusion: There was statistically significant correlation between Zn and Mg feeding with erection dysfunction in MetS patient.
Pengaruh pemberian pangan antioksidan terhadap kadar malondialdehid plasma mahasiswi penyuka gorengan
Authors: Makaryani Inti , Amalia Leily , Ramadhani Novi Rizqi , Pertiwi Karina Indah , Aprillia Desy Dwi
Published: March 2019

Background: Antioxidant elements such as vitamin C, vitamin E, lycopene, chlorophyl, polyphenol, and other flavonoid existed on various foods of fruits, vegetable, tea, coffee, and others. The foods are usually consumed in our every single day. Some previous studies had shown that there were various benefits of antioxidant elements for animal and human health. However, the antioxidative effect of the antioxidant elements in combating free radicals in the body is not similar to each other.Objective: This study was aimed to analyze the effect of antioxidant foods (green grass jelly drinks, tomato juice, papaya, and black tea) on blood levels of malondialdehyde (MDA) among college students.Method: The study was designed by pre-post test control study. Subjects were divided into five groups, consisted of four intervention groups and one control group. Every group consisted 6 persons. Each subject was asked to consume one kind of antioxidant foods in a single serving size per day for 21 days.Results: All of the subjects who consumed fried foods had high MDA levels in pre-intervention. The results of this study showed that MDA level in the group of green grass jelly drink decreased significantly (p<0.05). Plasma MDA levels tend to decline between pre and post intervention in the group of tomato juice, papaya, and tea, but they were not statistically significant (p>0,05).Conclusion: The antioxidant foods which can reduce plasma MDA level were green grass jelly drink. However, tomato juice, papaya, and tea can also reduce plasma MDA level, but not statistically significant.
Pola makan suku asli Papua dan non-Papua sebagai faktor risiko kejadian hipertensi
Authors: Bela Sarni Rante Allo , Djarwoto Bambang , Gunawan I Made Alit
Published: March 2019

Background: Hypertension is one of the problems in the medical and public health sector. The prevalence of hypertension in Jayapura City is 23,8%. Hypertensive disease was ranked 6th among the top 10 diseases in Abepura Hospital. The risk factors, a diet containing high fat, high sodium, low potassium and excessive alcohol consumption has contributed to the increasing of blood pressure.Objective: To determine the degree of hypertension difference between Papuans and non-Papuans, and the effect of intake of fat, sodium, potassium and alcohol consumption as risk factors for hypertension in each tribe.Method: The study was an observational analytic with a case-control design. Samples are 248 which is divided in 62 cases and 62 controls on each tribe. Data analysis using the statistical independent t-test, Chi-Square, Mantel Haenzel, Multiple Regression Logistic.Results: Non-Papuan tribes had 1.9 times higher risk of hypertension stage 2. The fat intake of indigenous Papuans (OR=3.250) and non-Papuans (OR=3.275) correlated significantly. Sodium intake significantly associated in indigenous Papuans, but the non-Papuans, have a significant relation (OR=2.531). There was a correlation between potassium intake in indigenous Papuans (OR=2.348), but the non-Papuans, was not. Consumption of alcohol in indigenous Papuans was significantly associated (OR=2.343), but the non-Papuans, was not. Multivariate analysis showed that psychosocial stress, consumption of alcohol, family history of hypertension, and potassium intake were contributing in indigenous Papuans. Intake of fat, sodium intake, and obesity was contributed in non-Papuan tribes. Conclusion: Non-Papuan tribes prone to has hypertension stage 2. In Papuans, fat intake (> 30%), potassium intake (<2000 mg) and excessive alcohol (≥ 2 glasses/day) are risk factors. In the non-Papuan, fat intake (> 30%) and sodium intake (≥ 2300 mg) are risk factors for hypertension.
Penerapan algoritma proses asuhan gizi terstandar berbasis skrining gizi
Authors: Susetyowati Susetyowati , Hadi Hamam , Asdie Ahmad Husein , Hakimi Mohammad
Published: March 2019

Background: Malnutrition is one common problem for hospitalized patient, estimated between 20-60%. American Dietetic Association (ADA) recommends a standardized Nutrition Care Process (SNCP) that ensures services and outcomes in the quality management of nutrition care to all patients based on an individual basis and scientific facts. In Indonesia was developed nutrition screening tool, namely the Simple Nutrition Screening Tool (SNST) which was valid and reliable.Objective: The study was to determine the effect of SNCP based on screening to improve nutrient intake and nutritional status.Method: The method using a 2x2 factorial design, with 4 groups which are: screened with Nutritional Risk Screening (NRS) and get hospital-based SNCP (A1B1); screened with NRS and algorithm SNCP (A1B2); screened with SNST and get hospital-based SNCP (A2B1); screened with the SNST and get algorithm SNCP (A2B2).Results: Nutritional screening interventions using NRS and SNST method can increase the energy and protein intake also Mid-Upper Arm Circumference (MUAC). There is no relationship between algorithm SNCP with nutrient intake and nutritional status, although the average intake of energy, protein, MUAC and albumin was better in the algorithm SNCP than in hospital-based SNCP. The interaction between the SNST and algorithm SNCP have better mean intake of energy, protein and MUAC changes than other groups. The size of the effect of energy intake, protein intake, and MUAC was 129 kcal; 4.6 g; and 0.35 cm, respectively.Conclusion: Interaction between an SNST and algorithm SNCP have a better average intake of energy, protein, and MUAC compared with other groups.
Berat badan lahir rendah (BBLR) dengan kejadian stunting pada anak usia 6-24 bulan
Authors: Nasution Darwin , Nurdiati Detty Siti , Huriyati Emy
Published: March 2019

Background: Stunting is one of the main problems of malnutrition often found in under-five children. The impacts include a delay in child’s growth, low endurance, lack of intelligence and productivity. The direct factors that influence the incidence of stunting are low birth weight (LBW) while the indirect factors are socioeconomic factors such as maternal education, low family income and a large number of family members.Objective: To analyze the relationship between LBW and the incidence of stunting in children aged 6-24 months in Yogyakarta Municipality.Method: This was a case-control study. The subjects were children aged 6-24 months with a group of cases comprising stunted children based on the indicator of height/age with a cut-off < -2 SD Z-score and the control group comprising normal children. The number of subjects for the study was 242 with the under-five children’s mothers as the research respondents. The sample selection used non-probability sampling with a consecutive sampling method. The data were analyzed by Chi-Square and multiple logistic regression.Results: The proportion of children 6-24 months who had low birth weight was 15.7 %. There was a significant relationship between LBW and the incidence of stunting in children aged 6-24 months (OR=5.60; 95%CI:2.27 to 15.70). There was a relationship between maternal height and the incidence of stunting in children aged 6-24 months (OR=2.14; 95%CI:1.08 to 4.33). Socioeconomic factors (maternal education, family income and a number of family members) did not have a significant relationship with the incidence of stunting.Conclusion: LBW had a relationship with the incidence of stunting in children aged 6-24 months in Yogyakarta Municipality.
Batasan indeks massa tubuh dan lingkar perut diabetesi di Indonesia untuk prediksi abnormalitas kadar HDL-kolesterol dan tekanan darah
Authors: Nazarina Nazarina , Prihartini Sri , Rachmawati Rika
Published: March 2019

Background: According to National Basic Health Survey (Riskesdas) 2007 and 2013 in Indonesia, diabetes prevalence had been increasing from 1,1% to 1,5%. Diabetic tends to have obesity related to abnormal blood lipid level and high blood pressure which lead to some complications such as cardiovascular diseases and hypertension. Therefore early prevention of complications is needed.Objective: This study was to identify body mass index (BMI) and waist circumference (WC) cut-off point in Indonesian diabetic as the predictor of lipid profile and high blood pressure abnormality.Method: The Crossectional study using secondary data, Riskesdas 2007. Subjects in this study were 615 diabetics who admitted been diagnosed as diabetes by physicians and/or had oral glucose test result ≥ 200 mg%. Data that had been analyzed were lipid profile (total cholesterol, LDL-chol, HDL-chol) and systolic-diastolic blood pressure, BMI (kg/cm2), WC (cm), lifestyle, and subject’s characteristic. Receiver Operating Characteristic (ROC) is used to identify BMI and WC cut-off point for predicting lipid profile and blood pressure abnormality.Results: On the average, subjects have high blood pressure and dyslipidemia. Both IMT and LP are able to predict high blood pressure and low HDL-chol significantly (AUC ≥ 59; all p>0,05). BMI=23 kg/cm2 can predict low HDl-chol (Se=63,3%; Sp=54,0%; p=0,04), high systolic (Se=68,3%; Sp=60,6%; p=0,000) and diastolic (Se=68,3%; Sp=60,6%; p=0,000) blood pressure in men, whereas in women can predict only low HDL-chol (Se=72,3%; Sp=47,8%; p=0,000). LP=80 cm can screen high systolic (Se=73,8%; Sp=63,6%; p=0,000) and diastolic (Se=72,4%; Sp=55,3%; p=0,000) blood pressure in men and high systolic blood pressure in women (Se=71,5%; Sp=52,6%; p=0,000). However, to predict low HDL-chol in women, cut-off point of LP is 78 cm (Se=74,2%; Sp=41,5%; p=0,003).Conclusion: Although BMI and LP can be used to predict high blood pressure and low HDL-chol, however, both measures have the different function when they are applied to both gender. To predict low HDL-chol in men and women, BMI=23 kg/cm2 can be used, and LP=80 cm can be applied to screen high systolic blood pressure in both genders. Nevertheless, more research is needed to show the consistency of these results, such as using better study design and considering for confounding variables (ethnic, diabetes duration, lifestyle, hypertension, and diabetes medicine).
Pengaruh pemberian makanan tambahan (PMT) pada ibu hamil terhadap berat lahir bayi
Authors: Zulaidah Hana Shafiyyah , Kandarina Istiti , Hakimi Mohammad
Published: March 2019

Background: Anemia causes fetal growth disorders that affect birth weight. Antenatal care (ANC) coverage and provision of high Fe if not followed by a decrease in the incidence of anemia can result indirectly in the risk of low birth weight. Supplementary feeding is expected to resolve the issue.Objective: To assess the effect of supplementary feeding on the third trimester of pregnancy on birth weight.Method: This was a quantitative study with a study design of quasi-experiment and non-equivalent control group. The given intervention was fish-processed feeding for 30 days. The study population was pregnant women in the third trimester in all health centers in the City of Yogyakarta and the samples were 104 pregnant women in some health centers with convenience sampling technique. The subjects were divided into two, namely the treatment group (PMT) and the comparison group (non-PMT). Birth weight was weighed immediately after the baby was born. Statistical analysis used t-test and logistic regression. Results: The mean birth weight of infants in the treatment group and the comparison group was 3248 g and 2974 g, respectively, so that the difference in the mean birth weight of both groups was 274 g (p=0.0002; 95%C:131-416). Thus, supplementary feeding was shown significantly affect the birth weight. The extraneous variables that significantly influenced birth weight were pregnancy interval. Other extraneous variables were age, mid-upper-arm circumference (MUAC), education, occupation, economic status, parity, protein intake, compliance of Fe tablet intake, antenatal care, gestational age at delivery and anemia status were not proven statistically significant to affect birth weight. Conclusion: Supplementary feeding effect on birth weight.
Efektivitas minuman kombinasi maltodekstrin dan vitamin C terhadap hitung jenis leukosit pada atlet sepak bola
Authors: Mahfida Silvi Lailatul , Kandarina Istiti , Farmawati Arta
Published: March 2019

Backgrounds: The immune system changing affects the fitness. Exercise induces the immune responses, oxidative stress and tissue damage that alters leukocyte counts. Maltodextrin supplies higher energy reserves, that can improve the immune system profiles. Vitamin C as an antioxidant against tissue damage.Objective: This study aims to assess the effectiveness of a maltodextrin and vitamin C combination drink on leukocyte differential count after exercise.Method: This study was quasi-experimental with the within-subject design. Subjects were 14 collegiate football players of the State University of Yogyakarta and fulfilled the inclusion and exclusion criteria. Subjects were selected with a purposive sampling. Subjects received a combination of 15% maltodextrin and 250 mg of vitamin C beverage, 300 mL. Subjects did wash out for 6 days, then received placebo beverage (300 mL plain water). Subjects drank 30 minutes before and 5 minutes after physical exercise. Exercise loads were yoyo intermittent test and run gradually until 80 HRmaks. Blood samples were taken immediately and 30 minutes after exercise.Results: In the administration of intervention beverage, immediately to 30 minutes after exercise neutrophils increased (p=0,006); lymphocytes decreased (p=0.015); monocytes decreased (p=0.000); and eosinophils decreased (p=0.613). In the administration of placebo beverage, immediately to 30 minutes after exercise, neutrophils increased (p=0.359); lymphocytes decreased (p=0.257); monocytes decreased (p=0.146); and eosinophils increased (p=0.549). Neutrophils (p=0.003) and monocyte (p=0.003) had significant difference between both administration drink at 30 minutes after exercise. Lymphocyte and monocyte significantly decrease (p<0.05) at intervention than placebo.Conclusion: Maltodextrin and vitamin C combination drink effect on the decreasing of lymphocyte and monocyte 30 minutes after exercise.
CLINICAL-DIAGNOSTIC VALUE OF BORDETELLA PERTUSSIS GENETIC MARKERS IN CONTACT PERSONS IN FAMILIAL FOCI
Authors: Nesterova Yu. V. , Medkova A. Yu. , Babachenko I. V. , Semin E. G. , Kalisnikova E. L. , Sinyashina L. N. , Karataev G. I.
Published: March 2019

Goal. Evaluation of duration and frequency of Bordetella pertussis DNA detection in contact persons in family foci of whooping-cough.Materials and methods. 116 persons from 59 family foci of pertussis were examined in contact with sick young children. The DNA of B. pertussis bacteria in nasopharyngeal swabs was detected by real-time PCR (PCR-RV) using a test system developed at Gamaleya Research Institute of Epidemiology and Microbiology (Moscow). The bacterial load and the duration of the release of genomic equivalents (GE) of B. pertussis DNA were determined in dynamics at 1, 3 and 6 months.Results. Among the contact persons in family foci, adults accounted for 59,48%, adolescents and schoolchildren – 10,35% and 12,07% respectively. Cough was absent in 35,34% of contact persons, 20,69% had a rare dry cough, 24,14% had a dry compulsive cough and 19,83% had a typical cough. None of the contact family members were diagnosed with whooping cough, although 64.66% of the patients had clinical signs of the disease, mainly its atypical form (44.83%). Among the carriers of B. pertussis adults accounted for 82.92%, among patients with atypical forms of whooping cough – 51.92%. In the study of nasopharyngeal swabs using the PCR-RV method, it was found that 86.10% of the contact persons detected DNA of B. pertussis. After 3 months in 90% of the contacts, the DNA of pertussis causative agent was detected in a minimum amount of 101-102GE/ml in the sample. After 6 months, B. pertussis was sanitized in 50% of the examined patients. 12.5% of the samples identified avirulent forms of the causative agent of pertussis, formed as a result of movement of IS481 in operon bvgAS.The conclusion. In 86.1% of contact persons in family foci for a long time (from 3 to 6 months), detection of genetic markers of the causative agent of pertussis from the nasopharynx was noted, including 35.34% of those examined in the absence of cough. This, along with the reported genetic mutation in operon bvgAS in 12.5% of cases, can characterize the presence of persistence of B. pertussis, explaining its preservation in circulation in the conditions of mass vaccine prevention.
CLINICAL AND LABORATORY CHARACTERISTICS HIV-INFECTED PATIENTS WITH NEWLY DIAGNOSED KAPOSI’S SARCOMA
Authors: Renev V. D. , Lioznov D. A. , Leonova O. N. , Nekrasova A. V. , Antonova T. V.
Published: March 2019

Objective: to characterize the clinical and laboratory parameters of patients with HIV infection with newly diagnosed Kaposi’s sarcoma.

Materials and methods. The analysis of clinical and laboratory data of 25 HIV-infected patients with newly diagnosed Kaposi’s sarcoma who were treated in the in-patient department of St. Petersburg Center for the Prevention and Control of AIDS and Infectious Diseases in 2009-2017

Results. Ninety-two (n=23) patients were men. The median age at detecting HIV infection is 36 years. The manifestation age of Kaposi’s sarcoma is a median of 37 years. Elements of Kaposi’s sarcoma were located mainly on the skin of the lower and upper extremities, trunk, face and oral mucosa. Manifest CMV infection was registered in one patient, candidiasis of various localizations was found in 19 patients (76%), 2 of them also had one case of tuberculosis and toxoplasmosis. The viral load of HIV in the serum of patients upon admission to the hospital ranged from 26 159 to 2 755,549 copies/ml. The number of CD4 lymphocytes in the serum of patients is from 4 to 674 cells/μl. First-line antiretroviral drugs were prescribed to 20 (80%) patients, while the positive dynamics of sarcoma was observed in 8 patients. Four (16%) patients received antitumor treatment. The duration of hospitalization of patients ranged from 8 to 85 days (median 29). Twenty-one patients were discharged from the hospital, death was registered in 4 patients (16%).

Conclusion. Characteristics of patients with HIV infection with newly diagnosed Kaposi’s sarcoma are: the predominance of males aged 30-39 years; skin lesions of the limbs and trunk in the debut of the clinical picture of sarcoma; laboratory signs of pronounced immunodeficiency (in 75% of patients, CD4 lymphocytes in the serum are less than 200 cells/μl); high viral load of HIV in serum (in 88% of patients more than 100 000 copies/ml); frequent combination with other opportunistic diseases.
BACTERIOPHAGES AS EFFECTIVE ANTIEPIDEMIC AGENTS FOR CONTROL OF HOSPITAL-ACQUIRED INFECTION OUTBREAKS
Authors: Aslanov B. I. , Lubimova A. V. , Zueva L. P.
Published: March 2019

Antibiotic resistance threatens the effective prevention and treatment of healthcare associated infections which are the most frequent adverse event in health-care settings worldwide. There is an urgent need to investigate alterative preventive and treatment options while there are still a few antibiotics left. Bacteriophage (phage) therapy has been championed as a promising alternative to antibiotics.The aim of this study was to evaluate the efficacy of a therapeutic bacteriophages to control of Staphylococcus aureus and Klebsiella pneumonia outbreaks in newborn intensive care units.Materials and methods. Commercial bacteriophage cocktails targeting these paphogens was orally and locally given over 5 days to patients of neonatal intensive care units in Saint-Petersburg, Russia.Results. Bacteriophages were used as antimicrobial agents for control of three S.aureus outbreaks and one K.pneumonia outbreak. S.aureus infection incidence during the three outbreaks were 22.2%, 54.5% and 50.0% accordingly, and K.pneumoniae outbreak – 19.0%. After application of the phage cocktails among newborns, the incidence of infections caused by S.aureus and K. pneumoniae decreased to zero. All treatments were well tolerated. No adverse events were reported.Conclusion. Presented results clearly demonstrate high efficiency of bacteriophages. Phages have several features that make them potentially attractive antibacterial agents. Bacteriopahges are highly specific and very effective in destroying targeted bacteria, have only minimally impact on health-protecting normal flora bacteria, safe and rapidly modifiable to combat the emergence of newly arising bacterial threats.
STREPTOCOCCAL (GROUP A) INFECTION IN RUSSIA: STATE OF THE PROBLEM AND DEVELOPMENT TRENDS
Authors: Briko N. I. , Glushkova E. V. , Kakorina E. P. , Nikitin N. V.
Published: March 2019

Aim. To assess the current situation on streptococcal (group A) infection in Russia, to study the molecular properties and antimicrobial susceptibility of group A streptococcus isolated from patients with soft tissue infection.

Materials and methods. We performed a descriptive epidemiological study using official statistics. A total of 97 cases of soft tissue infection caused by group A streptococci were investigated for emm-types, the presence of genes of bacteriophage toxins and integrases by PCR and sequencing. We tested 91 strains for antimicrobial susceptibility by the micro dilution methods.

Results. From 2009 through 2017, 2.8 million cases (563 thousand primary cases) of group A streptococcal disease were reported. There was a decrease in the incidence of scarlet fever in Russia (31.5 per 100 000 population). In 2009–2017 the incidence of rheumatic fever and rheumatic heart diseases increase slightly but the prevalence of this forms group A streptococcal disease are decrease. Annually 2600 people die from the rheumatic fever and rheumatic heart diseases. Of the 97 cultures of group A streptococci, 33 were associated with invasive infection. We identified 33 different emm-type. All cultures contained speB gene. Some strains contained speA, and others speC genes. We did not find any correlation between the presence of bacteriophage toxin genes and the invasive properties of streptococci. Tetracycline and macrolides are ineffective in patients with of soft tissue infection

Conclusion. Streptococcal (group A) infection continues to be of significant social and economic importance for Russia. The streptococcus cultures isolated from patients with invasive forms were heterogeneous in molecular and biological properties and remained sensitive to penicillin antibiotics.
АCUTE INFECTION OF OPISTHORCHIS FELINEUS IN MOSCOW: CASES FROM DELIVERED FISH AND CASES IN TOURISTS TRAVELLED TO ENDEMIC REGIONS IN RUSSIA
Authors: Bronshtejn A. M. , Kozlov S. S. , Malyshev N. A. , Burova S. V. , Maksimova M. S. , Fedyanina L. V. , Davydova I. V.
Published: March 2019

We describe the human acute opisthorchiasis outbreaks in Moscow region acquired from eating raw Leuciscus idus, Abramis brama and Aspius aspius in 10 patiens: 5 delivered fish from Tyumen and Sverdlovsk regions and 5 – from fish during their travelling to Tomsk and Astrakhan regions. Although, 18 people had identical history of consumption raw fish 10 had clinical symptoms of which the most frequent one was febrile eosinophilic syndrome. Other 8 people had no clinical symptoms. Eggs of O.felineus were found in 10 patients. Due to risk of cholangiocarcinoma in patients infected with O.felineus we recommend one day of praziquantel 25 mg/kg TID. Although opisthorchiasis is not frequently reported in Moscow region, it should be considered in cases of unexplained acute febrile eosinophilic syndrome with cholestasis, especially when patients confirm the ingestion of raw fish.
INFLUENZA VACCINATION OF CHILDREN OF PRESCHOOL AGE IN THE RUSSIAN FEDERATION: COST-EFFECTIVENESS OF QUADRIVALENT VACCINE
Authors: Rudakova A. V. , Danilenko D. M. , Lioznov D. A. , Karpova L. S. , Kharit S. M. , Mikitenko E. V. , Uskov A. N. , Kolbin A. S. , Konovalova L. N. , Lobzin Yu. V.
Published: March 2019

According to requirements of WHO, the trivalent influenza vaccines (TIV) have to contain antigens of two influenza A strains (A/H1N1, A/H3N2) and one influenza B strain which can be presented by antigens of a virus of lineages Yamagata or Victoria. In a season of 2017/2018 the discrepancy of the vaccinal and circulating influenza B strains was noted that caused decrease in effectiveness of vaccination, especially at children’s age when the frequency of detection of influenza B is higher, than in other age groups. Now in the Russian Federation it is registered, in addition to TIV, quadrivalent vaccine (QIV) manufactured in the Russian Federation and including antigens of influenza B viruses of the two lineages.The purpose of work was assessment of the cost-effectiveness of QIV in comparison with TIV at children of preschool age on the basis of epidemiological data on the Russian Federation for a season of 2017/2018.Material and methods. The analysis was carried out by a modeling method from a health care system and societal perspective taking into account epidemiological data on the Russian Federation and the European data on effectiveness of TIV at citizens of various age. Indirect effect of vaccination was not considered. The cost of the TIV and QIV (Grippol plus and Grippol quadrivalent, respectively) corresponded to the registered price including VAT.Results. The analysis showed that use QIV instead of TIV for children of preschool age in an epidemiological season of 2017/2018 would allow to increase quantity of the prevented influenza cases by 17.1%. The prevented indirect costs exceed the prevented direct medical costs. The incremental cost-effectiveness ratio (ICER) is 1042.65-1093.7 thousand rubles/QALY in the analysis from the health care system perspective and 124.50-267.91 thousand rubles/QALY in the analysis from the societal perspective.Conclusions. Vaccination against influenza of children of preschool age in the Russian Federation in a season of 2017/2018 with quadrivalent vaccine would allow to increase significantly the number of the prevented cases of disease and could be considered as economically highly effective intervention. Reduction of vaccine price less, than for 5% in comparison with the registered price would allow to avoid completely additional budget burden.
HEMOPHAGOSYTIC SYNDROME IN A CHILD WITH SEPSIS CAUSED BY SERRATIA PROTEAMACULANS
Authors: Khaertynov Kh. S. , Anokhin V. A. , Lubin S. A. , Khaertynova A. Kh.
Published: March 2019

A clinical case of development of secondary hemophagocytic syndrome is presented on the background of sepsis caused by Serratia proteamaculans, in a child of monthly age, culminating in recovery. Hemophagocytic syndrome in the child developed on the 32nd day of life and was accompanied by fever, hepatosplenomegaly, anemia, thrombocytopenia, elevated blood levels of triglycerides and ferritin. Blood culture was positive for Serratia proteamaculans. Isolate of Serratia proteamaculans was resistant to aminopenicillins (including protected ones), 1–4 generations of cephalosporins and aminoglycosides but sensitive to ciprofloxacin and moderately sensitive to imipenem and meropenem. The duration of fever in the child was seven days, thrombocytopenia, hyperfertritinemia and hypertriglyceridemia – 28 days. The normalization of the indices of ferritin, triglycerides and platelets coincided with the reduction of bacteremia and high values of the C-reactive protein. The duration of bacteremia was three weeks: the isolation of Serratia proteamaculans from the blood occurred three times. Elevated levels of C-reactive protein in the blood were noted for 30 days. Reduced hemoglobin and red blood cells counts were noted for eight weeks. Positive dynamics of the hemophagocytic syndrome occurred as a result of measures aimed at treating sepsis – antibiotic therapy with imipenem in combination with ciprofloxacin, appointed by the decision of the medical commission on the basis of the sensitivity of Serratia proteamaculans to antibiotics, intravenous immunoglobulin, and infusion therapy. Glucocorticosteroids and cytotoxic agents (etoposide, cyclosporin A) have not been used in this case.
The Computational Approach for Recommendation System Based on Tagging Data
Authors: Nesvit Kateryna
Published: March 2019

Recommendation approaches like a platform for learning algorithm. We can use some predicted values to put them in the data pipeline forlearning. There is a hard nuance of how to calculate the similarity measurewhen we have a small number of actions at all, its not a new user or item to use cold start methods, we just have not enough quantity to say it may be interpreted like regularity. The frequency of tags what we would have fromusers will have a huge impact to predict his future taste. The article describes created a computational approach using as explicit and as implicit feedbacks from users and evaluates tags by Jaccard distance to resolve this issue. To compare results with existed numerical methods there is a comparison table that shows the high quality of the proposed approach.
Approximation of The Lower Operator in Nonlinear Differential Games with Non-Fixed Time
Authors: Iskanadjiev I.M.
Published: March 2019

Approximate properties of the lower operator in nonlinear differential games with non-fixed time are studied.
Fuzzy Topsis in the Assessment of OHS Management System
Authors: Tabor Joanna
Published: March 2019

Occupational health and safety (OHS) management is a cycle of decision-making processes, many of which are in fact multi-criterion processes in nature. Therefore, it is important to look for and develop tools to support decision-makers in their actions aimed at improving work safety levels. The objective of this paper is to propose and verify the fuzzy TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) method applied to compare and assess the ways OHS management systems function in different companies. The fuzzy TOPSIS method has already been used for a number of years in assessments of alternative solutions in many different areas, but the application that uses ordered fuzzy numbers is quite original in nature. It is especially beneficial to use the fuzzy approach in OHS management systems, as it makes it possible for experts to assess different criteria using most frequently used linguistic variables. The adopted approach was verified in the study of OHS management systems in four furniture manufacturing companies. Assessment criteria were requirements of the PN-N 18001: 2004 Standard. Thanks to the ordered fuzzy TOPSIS method, the analysed OHS management systems were streamlined from the point of view of 24 assessment criteria, and the best and the worst functioning system was identified. The approach presented here may constitute a significant tool for improving OHS management systems.
The Development of an Explosion Protection System in the Starting Air Manifold of a High Power Engine
Authors: Chybowski Leszek , Kazienko Damian
Published: March 2019

In this paper, the authors have discussed the subject of fire and explosion hazards during the operation of a modern ship's high-power internal combustion engines. The causes of the occurrence of and the methods of preventing explosions in the starting manifolds of modern piston combustion engines equipped with a pneumatic starting system, with starting valves on the cylinder heads, have been specified. The concept of an active system for monitoring the technical condition of the starting valves has been presented in order to quickly diagnose leakages and reduce the risk of explosion. A conceptual design of a prototype of a non-invasive, new generation leak detector for starting valves and its technical design have been presented. Exemplary implementations of the prototype detector have been shown and its selected functionalities have been discussed. This paper has ended with an assessment of the possibility of further development and the applications of this device.
Ergonomic Evaluation of Working Position Using the Reba Method – Case Study
Authors: Pałęga Michał , Rydz Dariusz , Wojtyto Dorota , Arbuz Alexander
Published: March 2019

Provision of professional work is very often associated with the worker's exposure to the occurrence of various types of threats. Some of the most important include those related to physical overload. Excessive strain on the musculoskeletal system can lead to muscle, ligament and tendon injuries. Therefore, it is necessary to evaluate the workplace in terms of its ergonomics. This paper presents the assessment of the load of the worker's movement system using the REBA method, which takes into account the location of: head with neck, torso, lower limb, as well as hands with the wrist, forearm and arm.
Human Factor Management in Fire Protection and in Evacuation from Public Utility Objects
Authors: Sroka Mariusz
Published: March 2019

The study presents general assumptions of policies related to fire protection and evacuation of public buildings. Have been defined groups of human factors that have a significant impact on the efficiency of preventive actions taken and in the event of a threat. Next, the research methodology and results of questionnaire surveys carried out in randomly selected student groups are presented. A number of management actions aimed at increasing the safety of people staying on public facilities have been identified. The article ends with conclusions from the conducted research.
Assessment and Management of Risk in Improving the OHS Management System
Authors: Górny Adam
Published: March 2019

The paper discusses options for assessing risks with a view to identifying the nature and scope of the impacts of non-conformities and defining improvement opportunities. Such options are described in terms of hazards and opportunities. The opportunities reflect the measures required to increase the chances of establishing more effective safety management systems. The hazards reflect the circumstances that may prevent organizations achieving the desired benefits and that must therefore be eliminated in the course of system deployment and operation. Once identified, the above will help build the capacity to improve the existing management system in any organization that seeks to systemically modify its occupational safety system. The paper invokes the requirements set forth in ISO 45001, which it cross-references with binding legislation (including Directive 89/391/EEC). The approach helps define the benefits to be derived from assessing risks with a view to identify improvement opportunities and hazards by methods best suited to an organization’s environment.
The Security of Information Channels in Banking Services
Authors: Olkiewicz Marcin , Terebecki Mariusz , Wolniak Radosław
Published: March 2019

This study focuses on the aspects related to the information technology security, and in particular, the quality of information security. It is inter alia because of international technology security that banks incur expenses to adapt their IT systems to guidelines of the supervisory authorities and to the expectations of international financial markets and stakeholders.

The constantly growing demands of stakeholders increasingly force the provision of services to be on the highest standard and delivered by means of new technologies. Therefore, banks adjusting their products and services to the requirements of stakeholders have to implement modern methods to secure information channels, thus guaranteeing information security to the stakeholders of a bank.

The aim of this paper is to present crucial security aspects in electronic banking, which indirectly affect the quality and security of the offered banking service and whether clients are aware of the most commonly occurring threat - an attack on a computer (phising). The source of data for this research was a group of 90 active users of information technologies, the analysis of certificates and securities used at the time of contact between the customer and the bank through an internet platform and a report of PRNews.pl on the state of banking in Poland for the fourth quarter of 2016.
Analysis of the Accidental Release of Chlorine
Authors: Stolecka Katarzyna
Published: March 2019

Due to its properties, chlorine is one of the highly toxic substances used by humans. This gas attacks the respiratory system, eyes and skin. In higher concentrations, its inhalation leads to death. It is mainly used in water treatment plants where it guarantees a bacteriologically safe water in water supply systems. It is also used as a disinfectant and bleaching agent.

The use, transport and storage of chlorine may pose serious hazard associated with its uncontrolled release from technological installations or tanks. The level of this threat will depend on the run of the release scenario or meteorological conditions. The article presents an analysis of the hazards associated with the uncontrolled release of chlorine. The ranges of zones with dangerous level of gas concentration are presented as a result of its instantaneous and continuous release.
Creating Value Added for an Enterprise by Managing Information Security Incidents
Authors: Justyna Żywiołek , di Taranto Alberto
Published: March 2019

This article presents the structure and analysis of information security incidents in a production company in 2015-2017. The purpose of the analysis is to identify incidental events and their frequencies. The analysis includes the occurrence of notifications, threatening events, employee errors and false alarms. The conducted research includes also the procedure for handling the incident in the enterprise. The enterprises very often avoid informing their contractors about the occurrence of incidents. Thanks to the analysis of incidents and a clearly defined action plan, the examined enterprise tested the incidents and actions taken with them as a method of creating the added value of the enterprise during the period under consideration. The conducted research has shown that contractors who are aware of preventive actions taken, as well as those affecting information security even after the occurrence of an incident, are more willing to provide trust and even support to the surveyed enterprise. The conducted analysis is a pilot study carried out in one large enterprise in the metallurgical industry. The aim of the conducted research is to show that the incident or negative event may have a positive impact on the company's image. The research was carried out with the use of a questionnaire and in-depth interview with representatives of enterprises that are co-operators of the examined company.
Dynamic Management of Occupational Health and Safety Processes in Integrated Business Information Systems
Authors: Turek Tomasz , Bajdor Paula
Published: March 2019

Currently operating enterprises are more and more willing to adopt a process approach in their structures. The process approach means the transition from traditionally understood management towards adapting to constantly changing environmental conditions. This change is accompanied by the possibility of using a wide range of tools of ICT technology, that allow modelling of any type of process occurring in the enterprise, including processes related to OHS. Thus, the objective of the paper is to indicate the opportunity for the integration of OHS processes with other processes (primary and auxiliary) of the organization using ERP systems. In the first part of the study, there will be indicated the determinants of the development of the process approach in modern enterprises. Subsequently, there will be characterized OHS processes against the background of other processes of the organization. In the third part, there will be indicated the most significant features of ERP systems. The last part will refer to the practical implementation of the process in the area of OHS in the Macrologic Merit system.