bluuebunny/crossref_metadata_2025 huggingface dataset:
DIABETES MEDICATIONS AS MONOTHERAPY OR METFORMIN - BASED COMBINATION THERAPY FOR TYPE 2 DIABETES : A SYSTEMATIC REVIEW
Authors: Andreria Hatulely Chrysman
Published: August 2023

Introduction: Early combination therapy may reduce glucotoxicity. This method may improve insulin sensitivity and preserve bulk and function.10 Early combination therapy with several antihypertensive agents may increase costs and patient compliance due to the number of pills, but a fixed-dose medication combination can help.
The aim: This article compared monotherapy or metformin - based combination therapy for type 2 diabetes medications
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
 
Result: In the PubMed database, the results of our search brought up 88 articles, whereas the results of our search on SagePub brought up 56 articles. The results of the search conducted for the last year of 2013 yielded a total 42 articles for PubMed and 31 articles for SagePub. In the end, we compiled a total of 11 papers, 7 of which came from PubMed and four of which came from SagePub. We included three research that met the criteria.
 
Conclusion: Initiation of the AHA combination of metformin and other drugs may provide better results in diabetes control. In addition, the combination of two and three drugs did not show significantly different results.
A Review of Medical Data Sources, and Advanced Data Analytics in the Medical Sector
Authors: Eddie June Huh
Published: August 2023

This article provides a thorough examination of healthcare data analytics and identifies various unresolved questions that necessitate further investigation. The implementation of healthcare analytics has the potential to generate two supplementary advantages for healthcare providers, specifically heightened patient contentment and ameliorated health consequences. The field of data analytics has been propelled forward by the facilitation of healthcare data acquisition through technological and software advancements. The lack of a predetermined framework in the data, along with the constraints imposed by privacy considerations in data gathering and dissemination methods, have presented significant obstacles to the progression of the field. The expeditious handling and comprehension of data requires prompt decision-making in the presence of substantial information quantities. In specific situations, the retrieval and analysis of data may necessitate the utilisation of more advanced techniques owing to the intricacy of the data. The emergence of data collection technologies that facilitate analytics has presented new obstacles, despite their effectiveness in accumulating vast quantities of data. The healthcare industry employs a wide array of methodologies, which can be attributed to the inherent distinctions in the fundamental data types.
Interventions for Disrupted Sleep Patterns and Insomnia in Pediatric and Adolescent Populations Diagnosed with ASD
Authors: Akl Wael , Safwat Amr
Published: August 2023

The objective of this study is to develop a set of recommendations for effectively addressing sleep disturbance in adolescents and children with autism spectrum disorder (ASD). This will be achieved through a comprehensive evaluation of both pharmacological and non-pharmacological approaches utilised in the treatment of sleep disruptions in this specific population. Healthcare professionals who are providing care for adolescents and children with ASD and experiencing sleep disturbances should actively investigate potential underlying factors contributing to the disruption, such as medication usage or the presence of comorbid conditions. Subsequently, it is crucial for clinicians to address these identified causes in order to effectively manage the sleep disturbances. When managing sleep disturbance, it is advisable for clinicians to first suggest behavioural interventions, either independently or in combination with pharmacological or nutraceutical treatments, in order to facilitate improved sleep for children and their families. In cases where behavioural interventions prove ineffective and comorbid conditions and concurrent drug usage have been appropriately managed, healthcare professionals may contemplate the administration of melatonin, commencing with a conservative dosage. It is advisable to recommend melatonin of pharmaceutical grade if it is readily available for clinical use. It is incumbent upon healthcare professionals to engage in comprehensive discussions regarding the potential advantages and drawbacks associated with the utilisation of melatonin among paediatric patients, adolescents, and their guardians.
Influence of Small-Sided Games and Motor Ability in Performance Games Development
Authors: Pahlevi Aditya , Munir Ali
Published: August 2023

The purpose of this study is to be able to determine whether there is an influence of small sided games and motor ability on athlete performance in volleyball games. The method in this study is an experimental method where the design of this study uses factorial design. The results of this study show that small-sided games training methods, block system programs and random system programs have a significant effect on games performance, small-sided games training has interactions with motor ability that have different effects on games. While the small-sided games training method block system and random system programs have a significant effect on games performance in the high motor ability group, small-sided games training methods, block system programs and random system programs, do not have a significant effect on games performance in the low motor ability group. So that in providing volleyball training programs, especially the random system program, it should be given to athletes who have high motor ability. But for low motor ability can be used both programs, both block system programs and random system programs.
Keywords: Performance Games, Small-Sided Games, Motor Ability, Volleyball Information System
The Use of Simplified Learning Materials (SLM) in Physical Education as a Tool in Enhancing Students Learning Experiences
Authors: Culajara Carla Jobelle , Lao Anabella
Published: August 2023

The pandemic has allowed teachers to apply their innate abilities, such as creativity and innovation, and to impart comprehensive knowledge about physical education with simplified learning materials (SLM) that are centered on the contextual needs of students. The objective of the study is to determine the effect of Simplified Learning Materials (SLM) on students' learning performance in Physical Education. The study specifically aimed to determine the following: (1) evaluate the learning performance of the students in Physical Education before and after using simplified learning materials, and (2) identify the said significant differences between the students' mean scores before and after the intervention. The researchers used a pre-experimental design, specifically the One-Group Pretest-Posttest Design. The study was participated by 52 Grade 8 students in one of the secondary schools in the Philippines. Purposive sampling was used in the study. Data analysis was performed using the JASP software (weighted mean and paired t-test). Data revealed that the Shapiro-Wilk test of normality can be used to determine that the data does not deviate from the assumption of normality with a p-value of 0.305, which is greater than 0.05. According to the descriptive table, the post-test result is higher than the pretest result. The mean difference of -2.538 in the Paired Samples T-Test results is significant, with a p-value of 0.002 for the test. The use of Simplified Learning Materials (SLM) helps grade 8 students perform better on tasks and grasp understanding to the lesson related to physical education. This shows that the intervention has a significant effect on the student’s learning performance in Physical Education.  Future researchers can utilize the findings as a foundation to use simplified learning materials (SLM) for further contextualize and address what students need to accomplish.
Keywords: JASP Software, Learning performance, Modality, Physical education, Simplified Learning Materials
Effect of Limb Power, Arm Power, Hand Eye Coordination on the Combination of Punches and Kicks of Martial Arts Athletes
Authors: Putra Jeki Purnama , Kusmaedi Nurlan , Mulyana Mulyana , Ma’mun Amung
Published: August 2023

Low achievement in the sport of martial arts is influenced by several factors in the direction of physical condition and the ability to combine punches and kicks.  This type of research is quantitative research with an associative correlation approach with a method (path analysis). The purpose of this study is to determine the influence both directly and indirectly of the combination of punches and kicks. The sample in this study was 30 athletes, the sampling technique used purposive sampling technique. Punch and kick combination test to measure athlete's attack combination ability, Vertical Jump measures limb power, two hand medicine ball put measures arm power and hand-eye coordination with tennis ball catch throw In this limb power instrument has a validity value of 0.67, and test reliability of 0.79. Data analysis techniques use path analysis techniques. Results show 1). The direct effect of limb power on the combination of punches and kicks of Riau Holy Site athletes is 6.30%. 2). Direct influence of arm power on the combination of punches and kicks of Riau Holy Site athletes 8.47%, 3). The direct influence of eye-hand coordination on the combination of punches and kicks of Riau Holy Site athletes 23.04. This research only discusses a few factors that affect the combination of punches and kicks of athletes, there are many other factors such as agility, speed, accuracy, etc.  That way, it is hoped that there will be further research that examines other variable factors so that all aspects that can affect the combination of punches and kicks can be analyzed and get answers so that they can improve the achievements of Indonesian martial arts athletes, especially Riau sacred site athletes.
Keywords: Limb Power,  Arm Power, Hand Eye Coordination, Combination of Punch, Kick
Eye-Hand Coordination and Agility with Basketball Lay-Up Skills: A Correlation Study in Students
Authors: Suryadi Didi , Suganda Mikkey Anggara , Samodra Y Touvan Juni , Wati Isti Dwi Puspita , Rubiyatno Rubiyatno , Haïdara Youssouf , Wahyudi Ibnu , Saputra Eko
Published: August 2023

The skill of laying up a basketball is one of the important techniques that plays a role in giving pounds or numbers in the game. Therefore, it is necessary to know aspects related to lay up skills. This study aims to prove the relationship between eye-hand coordination and agility with basketball lay-up skills. In this study, a quantitative descriptive approach was used with the correlation study method. The subjects in this study were male students of class VII SMP St. Francis of Assisi Pontianak, totaling 25 male students. Data analysis in this study was assisted by using SPSS Version 26. Results of eye-hand coordination research with lay-up skills showing a significance value of 0.000 > 0.05, there is a significant relationship between eye-hand coordination and lay-up skills in students. agility results with lay-up skills showing a significance value of 0.004 > 0.05, there is a significant relationship between agility and lay-up skills in students. Furthermore, eye-hand coordination and agility with lay-up skills show a significance value of 0.000 < 0.05, so there is a significant relationship. The conclusion is that eye-hand coordination and agility have a significant relationship to lay-up skills in students.
Keywords : Agility, Basketball, Hand-Eye Coordination, Lay Up Skills
Improving the activities of public supervisory commissions (on the example of the Republic of Belarus)
Authors: Тит А.А.
Published: August 2023

В статье рассматриваются теоретико-прикладные аспекты деятельности института общественных наблюдательных комиссий как субъекта, осуществляющего общественное воздействие на осужденных. Для наиболее эффективной реализации общественного воздействия на осужденных автором аргументирована необходимость совершенствования организационно-правового механизма и правового статуса общественных наблюдательных комиссий. Также автором обосновывается тезис о необходимости наделения общественных наблюдательных комиссий полномочиями координирующего субъекта при реализации мер общественного воздействия на осужденных и выполнении мероприятий, направленных на ресоциализацию осужденных.

The article examines the theoretical and applied aspects of the activities of the institute of public monitoring commissions as a subject exercising public influence on convicts. For the most effective implementation of public influence on convicts, the author argues for the need to improve the organizational and legal mechanism and the legal status of public monitoring commissions. The author also argues for the need to empower public monitoring commissions with the powers of a coordinating entity in the implementation of measures of public influence on convicts and resocialization measures.
Actual problems in the activities of censors of pre-trial detention centers and correctional institutions
Authors: Рысев А.А.
Published: August 2023

В статье рассматриваются вопросы, связанные с несовершенством законодательства РФ в области обеспечения права лиц, содержащихся в учреждениях уголовно-исполнительной системы, на переписку, а также организации деятельности должностных лиц по ее цензуре. Затронуты актуальные проблемы, которые служат причинами написания жалоб гражданами в связи с изъятием входящей и исходящей корреспонденции. Целью исследования явилась разработка предложений для внесения изменений в действующее законодательство в сфере уголовно-исполнительной системы для устранения проблем в практической деятельности сотрудников оперативно-розыскной деятельности. В процессе исследования проводилось анкетирование действующих сотрудников учреждений и органов УИС.

The article examines the imperfection of the legislation of the Russian Federation in the field of ensuring the right of persons held in institutions of the penal system to correspondence, as well as the organization of the activities of officials to censor it. The actual problems that serve as the reasons for writing complaints by citizens in connection with the withdrawal of incoming and outgoing correspondence are touched upon. The purpose of the study was to develop proposals for making changes to the current legislation in the field of the penal enforcement system, to eliminate problems in the practical activities of operational investigative officers. In the course of the study, a questionnaire was used of current employees of institutions and bodies of the criminal justice system.
Gaps in penal law: identification, elimination, filling and overcoming
Authors: Селиверстов В.И.
Published: August 2023

На заседании диссертационного совета НИ ТГУ.12.01, созданного на базе Юридического института федерального государственного автономного образовательного учреждения высшего образования «Национальный исследовательский Томский государственный университет», 14 апреля 2022 г. состоялась защита диссертации на соискание ученой степени кандидата юридических наук Храмова Александра Александровича на тему «Пробелы в уголовно-исполнительном законодательстве России» по специальности 12.00.08 — Уголовное право и криминология; уголовно-исполнительное право. Диссертационный совет под председательством заместителя председателя совета, доктора юридических наук, профессора О. И. Андреевой принял решение, что диссертация соискателя является научно-квалификационной работой, в которой на основании выполненного автором исследования решена научная задача, имеющая важное значение для развития отрасли уголовно-исполнительного права, которая соответствует критериям, установленным п. 9–14 Положения о присуждении ученых степеней, утвержденным постановлением Правительства РФ от 24.09.2013 № 842, а также о присуждении А. А. Храмову ученой степени кандидата юридических наук по специальности 12.00.08. Статья представляет собой отзыв официального оппонента на диссертацию, в котором подвергнуты анализу структура и содержание диссертации А. А. Храмова.

At the meeting of the NI TSU. 12.01 Dissertation Council, created on the basis of the Law Institute of the National Research Tomsk State University, on April 14, 2022, Alexander Khramov defended his thesis for the degree of Candidate of Legal Sciences on the topic “Gaps in the penal enforcement legislation of Russia” in the specialty 12.00.08 — Criminal Law and Criminology; penal enforcement law. The Dissertation Council under the chairmanship of Deputy Chairman of the Dissertation Council, doctor of law, professor O. I. Andreeva, decided that the applicant’s dissertation is a scientific qualification work in which, based on the research performed by the author, a scientific problem has been solved that is important for the development of the branch of penal enforcement law, which meets the criteria set out in paragraphs 9-14 of the Regulations on the award of academic degrees approved by the Decree of the Government of the Russian Federation No. 842 dated 9/24/2013, and also about awarding A. A. Khramov the academic degree of candidate of Law in 12.00.08 specialty. The article is an official opponent’s review of the dissertation, in which the structure and content of A. A. Khramov’s dissertation are analyzed.
Imposition of criminal punishment in the form of compulsory works: questions of theory and practice
Authors: Исаков В.С.
Published: August 2023

Проанализированы теоретические и практические проблемы назначения уголовного наказания в виде принудительных работ. Установленный порядок назначения принудительных работ противоречит основным положениям Уголовного кодекса РФ, а также подчеркивает диспозитивный для суда характер назначения наказания. Принудительные работы не только становятся низко востребованными по сравнению с остальными уголовными наказаниями, не связанными с изоляцией осужденного от общества, но и не выполняют должным образом функцию альтернативы лишению свободы. Обосновывается необходимость внесения изменений и дополнений в уголовное законодательство, связанных с назначением принудительных работ в качестве самостоятельного уголовного наказания. Назначение принудительных работ должно быть мотивировано не возможностью исправления осужденного без реального отбывания лишения свободы, а способностью подсудимого к выполнению порядка и условий (режима) исполнения (отбывания) принудительных работ и рядом других обстоятельств, вытекающих из содержания данного наказания.

This article examines the theoretical and practical aspects of the imposition of criminal punishment in the form of forced labour. The established procedure for imposing forced labour contradicts the basic provisions of the Criminal Code of the Russian Federation, and also emphasizes the dispositive nature of the punishment imposition for the court. For these reasons, compulsory works not only become in low demand compared to other criminal penalties not related to the isolation of the convicted person from society, but also do not adequately perform the function of an alternative to imprisonment. It is necessary to introduce amendments into the criminal legislation related to the imposition of compulsory works as a separate criminal punishment. The appointment of forced labor must be motivated not by the possibility of correcting the convict without actually serving the deprivation of liberty, but by the ability of the defendant to comply with the procedure and conditions (regime) for the execution (serving) of forced labor and a number of other circumstances arising from the content of this punishment.
Maternal Violence Against Children: A Brief Literature Review
Authors: Martins Padilha Carolina Rizzatto
Published: August 2023

Domestic Violence against Children and Adolescents (DVCA) is considered a social and public health problem, which occurs in the private space of the family. Mothers are among those who most violate their children because they are the main ones responsible for their care. This review analyzed the articles published in the last 12 years that dealt with maternal violence. It was found that most of the studies were qualitative, written in Portuguese, carried out in Brazil, and in the area of psychology. The high production by Brazilian authors shows that this phenomenon has become visible in the country. Physical violence and neglect were the most highlighted and the mothers participating in the studies were mostly from lower socioeconomic classes. There is a gap regarding the inclusion of mothers with other socioeconomic characteristics and from other countries. The content of the articles provided a wealth of information about the life histories and personalities of these women, but only a minority explored the relational vicissitudes of the mother-child dyads, which could result in more comprehensive and effective intervention proposals in the context of DVCA.
The Return of Lands Disturbed by Mining Production to a New Economic Turnover – As the Final Stage of Mining Production (On the Example of Open-Pit Mining)
Authors: Svetlana Chmykhalova
Published: August 2023

Intensive development of mining production inevitably leads to depletion of natural resources, disruption of natural processes and pollution of the natural environment, which entails negative consequences for the socio-economic development of the region after the end of mining. During the extraction of minerals, the integrity of the subsoil is violated, the lithosphere is polluted, wastewater is discharged into the hydrosphere, and dust and harmful gases are released into the air. Mining production can be attributed to natural-technical (technological) systems. The main technological process is associated with the extraction of minerals from the bowels, i.e. the impact on the bowels of the Earth with the help of various technical means and technologies. The subsoil, atmosphere, hydrosphere, soil are elements of the natural system. The complex of technologies and technical means is a technical (technological) system, the choice of which is determined by the properties of the field. Mining production has its own life cycle, which begins with the justification of the feasibility of mining, and ends with the liquidation of mining production and the transfer of disturbed lands to a new economic turnover. In order to return the disturbed lands to a new economic turnover, it is necessary to recultivate (restore) the lands disturbed by mining production. The study examines the conditions for the return of lands disturbed by mining production to a new economic turnover – as the final stage of mining (on the example of open-pit mining), taking into account the life cycle of mining production.
«Ce reconte l’estoire, ne seit om mescreans»: le lasse originali del ms. B del «Roman d’Alexandre»
Authors: Briano Simone
Published: August 2023

RIASSUNTO: Il contributo approfondisce le interpolazioni originali della particolare versione del Roman d’Alexandre contenuta nel manoscritto B (Venezia, Museo Correr 1493): un’approfondita analisi lassa per lassa, mai tentata finora nonostante l’importanza del codice nella tradizione del Roman d’Alexandre, dimostra i punti di contatto del testo con altre opere della galassia alessandrina, come l’Historia de Preliis, il Libro de Alexandre e l’Alexanderlied, ma anche influenze difficili da rintracciare, legate – tra l’altro – alla letteratura cristiana apocrifa e a leggende ebraiche su Salomone.

 

PAROLE CHIAVE: Roman d’Alexandre, interpolazioni, Alessandro Magno, tradizione manoscritta, Babilonia
«La housse partie» nelle tre versioni A, r e s
Authors: Bonanno Laura
Published: August 2023

Il presente articolo propone il confronto delle tre versioni del fabliau La housse partie, partendo da alcune considerazioni riguardanti i motivi letterari che permeano i componimenti e l’appartenenza degli stessi al genere fabliolostico. Il confronto dei tre testi ha messo in luce elementi interessanti di questo fabliau da un punto di vista narratologico e letterario, ma anche peculiarità che hanno diviso la critica, come il suo carattere moraleggiante, i personaggi messi in scena e il tipo di pubblico al quale si rivolge. Infine, lo studio approfondito de La housse partie ha permesso di formulare ipotesi circa la circolazione di questa storia in epoca medievale, la sua destinazione e il suo scopo.
A proposito di personaggi della letteratura medievale (l'esempio del ladro-mago)
Authors: Bonafin Massimo
Published: August 2023

In questo articolo si discute lo statuto del personaggio medievale e le prospettive di ricerca al riguardo, prendendo spunto da una recente pubblicazione dedicata alla figura di Maugis/Malagigi
Ancora sull'etimo di marmotta
Authors: Cornagliotti Anna
Published: August 2023

Si offre una nuova proposta etimologica del termine marmotta.
Biocompatibility Study with Baby Hamster Kidney Cells on Acetobacter Xylinum Pellicle for Diabetic Foot Laceration
Authors: Paramadini Adanti Wido , Faizah Faizah
Published: August 2023

Diabetes mellitus, commonly known as diabetes, is a persistent metabolic condition marked by elevated blood glucose levels. This condition's global prevalence has been consistently increasing, becoming a major cause for concern in public health on an international scale. This disease can lead to various complications, including impaired wound healing. The purpose of this study is to determine the cytotoxicity level of hydrogel membranes made from Acetobacter xylinum and whether the used method is appropriate for producing proper wound healing material. The findings of the study, employing BHK Kidney cells and the MTT Assay technique, revealed that the dehydrated hydrogel membrane derived from bacterial cellulose and processed through oven drying exhibited a toxicity level of less than 50% across all samples. Additionally, the swelling test indicated a rise in water absorption when the membrane was combined with collagen material
KİNEZYO BANTLAMA TEKNİĞİ: DİZ OSTEOARTRİTİNDE KANITA DAYALI UYGULAMALAR
Authors: Karakaya Eda Seren , Ersin Aybüke
Published: August 2023

Diz osteoartriti (OA), ağrı, fiziksel fonksiyon bozukluğu gibi yaşam kalitesinin azalmasına sebep olan sonuçlara yol açmaktadır. Kinezyo bantlama (KT) tekniğinin diz osteoatritli hastalarda olumlu sonuçlara yol açtığı, ağrı ve fonksiyonellik üzerine olumlu etkileri olduğu çalışmalar mevcuttur. 1907’li yıllarda Dr. Kenzo Kase tarafından geliştirilen bu teknik normal boyutunun %140’ına kadar uzayabilen, akrilik, yapışkan, renkli elastik koton bir bant ile uygulanan özel bir bantlama tekniğidir. Longitudinal yönde dinlenme uzunluğunun %55-60’ı oranında esneyebilme özelliği olan bant, hareket ile birlikte cildin oluşturduğu gerilme ve gevşemeye uyum sağlayabilir, deri kalınlığını ve esnekliğini taklit edebilir. Cilt dokusuna bu kadar benzer özelliklerde olması hem uygulamanın devamlılığı hem bantın kullanımı hem de kişilerin bant toleransını maksimum düzeyde tutmaya yeterlidir. Bu teknik soruna yönelik çeşitli şekillerde uygulanabilmektedir. Bu derleme makalede Kinezyo bantlamanın diz orteoartriti olan kişiler üzerindeki etkinliği değerlendirmekte olup, KT tekniği hakkındaki mevcut kanıtları analiz edilmektedir. Bu derlemenin amacı, diz osteoartriti olan hastalarda kinezyo bantlama tekniğinin etkinliği hakkında güncel literatürü özetlemektir.
BABALARIN DİL VE KONUŞMA BOZUKLUKLARINA YÖNELİK BİLGİ DÜZEYLERİNİN İNCELENMESİ
Authors: Koçak Ayşe Nur , Akın Ceyda , Bayrak Özge Nur
Published: August 2023

Babalar, çocukların dil ve konuşma gelişimlerinde önemli rol oynamaktadır. Babaların, çocukların dil ve konuşma gelişimlerine etkisi bu derece büyük iken babaların çocuklarının dil ve konuşma güçlüğü yaşayıp yaşamadığını anlamalarına yönelik herhangi bir araştırmaya rastlanmamıştır. Bu önem kapsamında, babaların dil ve konuşma bozuklukları hakkında bilgi düzeylerinin ve tutumlarının incelenmesi amaçlanmıştır.
TİP 2 DİYABET VE İNKRETİNLERİN ETKİSİ
Authors: Gök Hatice
Published: August 2023

İnsanın yaşamının devamı, büyüme ve gelişmesi, sağlığının korunması için gerekli besin öğelerini doğru miktarlarda alıp, vücutta kullanılmasına beslenme denir. Beslenmenin ardından vücuttaki hormonların yeterli ve doğru salgılanması kişilerin sağlığı için önemlidir. Vücudumuzdaki insülin hormonun eksikliği ya da insülin eksikliği kaynaklı ortaya çıkan ve hiperglisemi ile karakterize Tip 2 diyabet dünyayı etkileyen önemli halk sağlığı sorunlarındandır. Patofizyolojisinin temelinde insülin direnci ve insülin sekresyonundaki azalmadır. Hastalığın ilerlemesiyle ilaç ve insülin kullanımı ortaya çıkmaktadır. Kullanılan ilaçlar ve insülin çoğu hastada tek başına uzun süreli tedavide yan etkilere sebep olmakta ve tedavinin etkinliği azalmaktadır. Günümüzde etkili glikoz kontrolü ve beta hücre fonksiyonunu düzenleyen inkretin bazlı tedavilerin önemi artmıştır. İnkretin, ağız yoluyla alınan karbonhidratların, intravenöz yolla verilen glukoza oranla intestinal hormon aracılı insülin sekresyonunu daha çok arttırması olarak bilinmektedir. İnkretin etkisi glikoza karşı insülin tepkisinin %50 ile %70’inden sorumludur. İnkretin hormonları glukagon benzeri peptid-1 (GLP-1) ve glukoza bağımlı insülinotropik polipeptit (GIP)’dir. Bu hormonlar, pankreas beta hücrelerinden glukoz ile indüklenmiş insülin sekresyonunu harekete geçirmek üzere intestinal mukozadan salınır. Yapılan son çalışmalarda tip 2 diyabeti tedavi etmek için GLP-1 tabanlı tedaviler ve Dipeptidil Peptidaz-4 İnhibitörü (DPP-4) inhibitörlerinin HbA1C’yi düşürme ve glisemik kontrolü düzenlemedeki etkilerinin saptanması üzerine ilave tedavi olarak inkretinlerin önemi ortaya çıkmıştır.
A Proposed Theory for the Pedagogic Practices in Alternative Learning System (ALS)
Authors: Labarrete Rufo Abiertas , Gillo Mariano D.
Published: August 2023

This study explored the pedagogic practices on modalities in facilitating instruction and assessing learning employed for the PDLs, IPs, and Non-Literate Adults as group of learners in the ALS and consequently propose a theory along these dimensions. Data were obtained from 18 purposively chosen programs-implementers through semi-structured, observations of class activities, and field notes. These were analyzed through Charmaz’ framework on grounded theory data analyses. Results of the findings showed that educational goods and services are delivered through flexible modalities specifically face-to-face aided with modern technologies and home visitation aided with traditional technologies. Assessment in learning, on the other hand, is realized in multi-modal fashion specifically trough performance-based, module-based, and portfolio assessment formats. These findings point towards a theoretical conception that the delivery of educational good and services is unique and dependent on the circumstance, condition, and situation of the target learners and assessing the learners’ learning is actualized in a multi-modal fashion in response and recognition of the learners’ diversity, diverse learning needs and teaching and learning environment. With these theoretical conceptions, the Granular Learning Theory is proposed. The basic tenet of the theory is that instructional delivery and assessment in learning are case-dependent.
FEASIBILITY STUDY OF UTILIZING SOYBEAN AS AN INTERCROP PLANT IN IMMATURE OIL PALM AS AN EFFORT TO INCREASE THE INCOME OF OIL PALM FARMERS
Authors: Dina Arfianti Saragih  , Delyana R. Pulungan  , Guntoro  , Ika Ucha Pradifta Rangkuti  , Tifany Zia Aznur  , Fadli Akbar Lubis  , Juhal Prayogie
Published: August 2023

Land utilization in immature palm oil is very helpful for oil palm farmers to get a source of income when their palm oil crops is still immature. In addition, these intercrops can also be used as ground cover plants, which can prevent erosion and evaporation of the soil. The research was conducted in the experimental garden of the Institut Teknologi Sawit Indonesia (ITSI). The research time was 3 months. The purpose of this research is to determine the feasibility study of soybean business as an intercrop in immature crop land whether or not this soybean crop is profitable. If it is profitable then farmers can receive income from this soybean intercrop before the palm oil plants can be harvested. The results of the research conducted are the production of soybean crops on immature palm oil land with a distance of 20 cm x 20 cm on 2 beds with a bed size of 4 m x 1 m is 10 kg. The total production cost of soybean intercrops in immature palm oil is Rp.86,861. Income on soybean crops in immature palm oil is Rp.130,000. The profit on soybean intercrops in immature oil palm is Rp.43,139. Soybean crops (Grobogan variety) in immature palm oil are financially and economically feasible, with an R/C value > 1, so the farming business is profitable. Break Event Point of soybean intercrops at immature oil palm, BEP production 6.68 kg BEP price Rp.8,686.
A review of the role of vitamin d in autoimmunity
Authors: Finamor Danilo Chiaradia , Bearzi Cristiane Fadel , Marim Giovana , Durante Fausto Rohnelt
Published: August 2023

Introduction: The main function of vitamin D is to increase the intestinal absorption of calcium, participating in the stimulation of active transport of this ion in enterocytes. Extra-renal hydroxylation of vitamin D also occurs, originating the vitamin that would act in an autocrine and paracrine manner, with functions of inhibiting cell proliferation, promoting cell differentiation, and immune regulation. Objective: It was to review the scientific literature on the role of vitamin D in autoimmunity. Methods: A search was carried out on scientific articles centered on the proposed theme: “Role of vitamin D in autoimmunity”. Several search engines that carried scientific information in the health area were used to carry out this study, such as Google Scholar and the Medical Publications database (PubMed), and Scientific Electronic Library Online (SCIELO). In collecting the information, the descriptors used to carry out this research were: vitamin D; vitamin D in preventing diseases; vitamin D and autoimmune diseases; vitamin D; autoimmune diseases. The inclusion criteria used in this study were publications of scientific articles available in full and with free electronic access, limited to a period between 2011 and 2022, and selected articles in Portuguese and English. Results and Conclusion: Based on this methodology, it was possible to analyze a population of 58 articles that were selected for the study and constituted the sample used in this review. Several studies point to the effects of vitamin D not related to calcium metabolism, such as antineoplastic activity (particularly concerning breast, colon, and prostate cancers, and lymphoproliferative diseases), antihypertensive and immunomodulatory. Vitamin D deficiency and its use for treatment have been described in various autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, lupus, inflammatory bowel disease, myasthenia gravis, scleroderma, alopecia areata, psoriasis, vitiligo, autoimmune hepatitis, type 1 diabetes mellitus, autoimmune thyroiditis, etc. The effects of vitamin D on the immune system are related to the tolerance of self-antigens, exerting an inhibitory effect on the Th1 and Th17 type lymphocyte pattern, and a promoting effect on the expression of the Th2 and Treg pattern through the action of vitamin D in all cells of the system through the vitamin D receptor. More studies are needed to establish safe and effective doses in the management of these properties of vitamin D.
AGROFLORESTA URBANA COMUNITÁRIA
Authors: Carboni Marina , Domingues Moço Vitoria Maria
Published: August 2023

O artigo apresenta o projeto de um sistema agroflorestal urbano associado à horta comunitária com o intuito de promover a revitalização de uma área verde urbana, que, atualmente não possui qualquer atrativo de lazer e recreação, nem tampouco arborização adequada. A agroflorestal além de conferir proteção do solo, poderá contribuir para a educação ambiental dos usuários da área conferindo pertencimento e conscientização sobre a importância do consumo de alimentos saudáveis para melhor qualidade de vida. Uma vez implementada a horta comunitária, será possível oferecer a população do entorno hortaliças e frutas. Além disso, a interação da comunidade com o sistema agroflorestal permitirá o aproveitamento dos serviços ecossistêmicos tais como: redução da temperatura no local e aumento da infiltração da água de chuva. A proposta pretende implementar a agrofloresta urbana associada à horta em uma área de 2.500m².  Serão 35 árvores de 8 espécies de arvores frutíferas e 9 espécies de hortaliças distribuídos em diversos canteiros.  A área será cercada para evitar roubos e vandalismo. A cerca servirá ainda de espaldeira para permitir o desenvolvimento de mudas de ora-pro-nóbis (Pereskia aculeata), uma planta alimentícia não convencional, trepadeira escandente com espinhos. Á agrofloresta comunitária foi inspirada nas hortas comunitárias de Jaú, sendo realizada uma visita técnica na horta municipal do Jardim Itamarati

Palavras-chave: Horta comunitária. Cinturão verde. Oferta de hortaliças. Área verde.
APLICAÇÃO DO SOFTWARE ARENA EM UMA INDÚSTRIA COSMÉTICA-CAPILAR PARA MELHORIA DE TEMPO, PRODUTIVIDADE E PROCESSOS
Authors: Vicente Bernardo Douglas Henrique , Lima Welington Renan , Bertoluci Evandro Antônio , Zem Lopes Aparecida Maria
Published: August 2023

Um gargalo no sistema produtivo ocorre quando um determinado funcionário, máquina ou processo não atende a demanda requerida em um determinado período. Um método que pode ser utilizado para descobrir as possíveis razões da formação dos gargalos operacionais é através de um software de simulação. Desta forma, este trabalho teve como objetivo propor melhorias no processo produtivo de uma indústria de cosméticos a partir das análises de resultados de simulações computacionais e investigar os gargalos no processo produtivo. Para o desenvolvimento do trabalho utilizou-se o método de pesquisa qualitativa tendo como referenciais artigos, livros e sites da internet e quantitativa realizada no campo de estudo, por meio da observação e simulações. A coleta de dados foi realizada com base nos tempos dos processos produtivos da fábrica. Com tal estudo, foi possível analisar os gargalos da operação e definir possíveis melhorias a serem implantadas, resultando na redução do tempo, maximização da produtividade e readequações de processos.
APRENDER BRINCANDO: CRIAÇÃO DE CIRCUITO PSICOMOTOR PARA EDUCAÇÃO INCLUSIVA
Authors: Silveira Maria Jéssica Rodrigues , Figueiredo Ana Amélia de Santi , Pascucci Marcella Marchesan Pascucci , Ventura Flávio Cardoso Ventura , Brancão Alessandro Lameiro Brancão
Published: August 2023

A Associação de Pais e Amigos dos Excepcionais (APAE) de Bariri é uma instituição sem fins lucrativos que atua diretamente na educação inclusiva, permitindo que portadores de necessidades educativas especiais consigam meios que favoreçam a sua integração na sociedade, geralmente, utiliza-se de jogos e brincadeiras como ferramentas que auxiliam na aprendizagem, no desenvolvimento pessoal, social, construindo novos conhecimentos que facilitam a vivência de seus educandos na sociedade. Contudo, a instituição enfrenta dificuldades para encontrar produtos adequados para prover um melhor tratamento aos seus alunos, devido as limitações do mercado em disponibilizar produtos que se adaptem as necessidades destes alunos. O presente artigo apresenta um projeto desenvolvido por alunos do curso de Gestão da Produção Industrial, da Faculdade de Tecnologia de Jahu, em parceria com a instituição social APAE de Bariri/SP, tendo como objetivo elaborar um dispositivo para trabalhar a coordenação motora ampla, equilíbrio, percepções gerais e o desenvolvimento da criança, proporcionando maior domínio de seu corpo no espaço. Esse estudo foi elaborado por meio de pesquisa aplicada de caráter experimental. Foram realizadas pesquisas e entrevistas de quais atividades atenderiam as necessidades da instituição, materiais que poderiam ser utilizados e cores a serem usadas. Mediante resultados das pesquisas foi elaborado um circuito de atividades feito com materiais usualmente encontrados no mercado, como por exemplo, tubos de PVC. Por meio do feedback da terapeuta ocupacional da instituição, o circuito atendeu às expectativas, auxiliando no desenvolvimento psicomotor das crianças com espectro autista e deficiência intelectual, também foi utilizado por outros alunos da instituição
DISPOSITIVO DE AUTOMAÇÃO DE RESIDÊNCIA PARA PACIENTES COM DOENÇA DE ALZHEIMER: UM PROTÓTIPO EM ARDUÍNO
Authors: Vicente Bernardo Douglas Henrique , Da Silva Wilson Viana , Zem Lopes Aparecida Maria
Published: August 2023

Devido ao aumento da expectativa de vida e consequente envelhecimento da população, estima-se que, até o ano de 2050, mais de 153 milhões de pessoas poderão sofrer com a Doença de Alzheimer (DA). Trata-se de uma doença degenerativa, na qual ocorre a perda das funções cerebrais, afetando a memória, a linguagem, a atenção etc. A perda da memória pode levar a outros sintomas, tais como dificuldade para falar, comer, andar, dentre outras complicações decorrentes. Neste contexto, o objetivo deste estudo foi desenvolver um dispositivo para automação de residência que ofereça autonomia para pessoas que sofrem com DA no estágio inicial e moderado. A metodologia envolveu pesquisa bibliográfica e estudo das ferramentas e mecanismos utilizados para automação digital. Além disso, utilizou-se a plataforma Arduíno para elaborar o protótipo do dispositivo, devido ao seu baixo custo e facilidade de uso. O dispositivo deverá ser instalado na parte superior do batente da porta de cada cômodo da residência e, toda vez que o paciente passar por ele, irá emitir um sinal de voz, que informará qual é a finalidade daquele ambiente e quais atividades costumam ser realizadas nele. É importante ressaltar que o dispositivo ainda não foi colocado em teste com seres humanos, para verificar como seria o seu funcionamento na vida real. Portanto, espera-se que, a partir de testes reais realizados em trabalhos futuros, o dispositivo possa ser otimizado e utilizado em outros contextos.
PROJETO VÊNUS: DESIGN DE PRÓTESES MAMÁRIAS (EXTERNAS) PERSONALIZADAS POR MEIO DE PROTOTIPAGEM RÁPIDA
Authors: Tilio Livia Maria de , Marangueli Hiago Henrique , Silva João Vitor Gazana Silva , Monteiro Rosangela dos Santos , Ventura Flavio Cardoso Ventura
Published: August 2023

A importância da reabilitação da mulher após o câncer de mama prolonga-se para muito além da cirurgia e dos tratamentos complementares. A dimensão psicológica da perda parcial ou total do tecido mamário, somada às alterações visuais e aos respectivos impactos na autoestima feminina, especialmente às mulheres não submetidas à reconstrução mamária, inspiraram o desenvolvimento deste trabalho. A evolução da tecnologia assistiva nos últimos anos tem estimulado a prototipagem rápida na área da saúde, sendo amplamente utilizada na produção de próteses. O objetivo deste estudo é apresentar a elaboração de próteses mamárias externas por meio da impressão 3D. Este trabalho foi realizado mediante pesquisa aplicada de caráter experimental. Na manufatura de próteses externas de mama, geralmente, utiliza-se o silicone moldável. Como diferencial proposto neste estudo, parte-se da diversificação dos materiais utilizados, escolhendo-se os filamentos de PLA (ácido polilático) flexível e a resina flexível para a impressão 3D. As próteses impressas em PLA flexível apresentaram melhor desempenho no quesito estabilização da mama e melhor poder de fixação no sutiã, porém, como ponto negativo, o contato com o referido material causou incômodo, provavelmente devido ao toque mais áspero do material junto a pele.
Competition Law Enforcement vs. The Policy Goal of an International Aviation Hub: Case Studies in East Asia
Authors: Lee Jae Woon
Published: August 2023

To what extent does the policy goal of an international aviation hub affect the enforcement of competition law? This article examines the dynamics between competition law enforcement and the policy goal of an international aviation hub in three East Asian competition jurisdictions: Singapore, Korea, and Hong Kong. Broadly speaking, industrial policy is one of the goals identified by some competition jurisdictions and plays an important role in enforcing competition law both explicitly and implicitly. While making an international aviation hub is a legitimate policy goal that competition law agencies can consider in their enforcement, competition law enforcers should be aware of the difference between making an international aviation hub and making a national champion airline. Although there is overlap between the two (i.e., having a competitive airline with a good network is helpful for making an aviation hub), the two are not identical and not always complementary. In keeping with the principle of competitive neutrality, this article argues that competition law enforcers should not selectively favour flag carriers when pursuing the policy goal of an international aviation hub.

aviation hub, competition law, industrial policy, competitive neutrality, national champion airline, state-owned airline
Responsibility of Targeted Actors in the Context of Restrictive Measures: The Case of Belaeronavigatsia
Authors: Pazos Ricardo
Published: August 2023

In the context of the Common Foreign and Security Policy (CFSP), the European Union may adopt restrictive measures, also known as sanctions, against natural or legal persons and groups or non-state entities. Such measures are one instrument – among many others – to achieve certain policy goals, including the protection of the Union’s values and the advancement of fundamental rights, democracy, and the rule of law. There are sanctions of different kinds to coerce, constrain, or signal a targeted actor, and they are chosen and combined with a view to implement the most effective strategy. Belaeronavigatsia, a state-owned enterprise engaged in regulating airspace and providing air traffic assistance in Belarus, was deemed responsible for the repression of civil society and democratic opposition following its involvement in a flight diversion that ultimately led to the arrest of an opposition journalist and his companion. As a consequence, the Council froze its assets, a decision the enterprise contested by arguing that it could not be held ‘responsible’ for the referred act, and that the sanction was not in accordance with the principle of proportionality. The judgment in the case Belaeronavigatsia v. Council offers an overview of the main features of restrictive measures, reminds the interpretative criteria for undefined notions in Council’s decisions and then clarifies the terms ‘responsible for the repression’ with a special focus on the element of causation, and assesses the principle of proportionality in an area influenced by political, economic, and social motivations, such as the CFSP.

CFSP, restrictive measures, sanctions, freezing of funds, responsibility, causation, proportionality