bluuebunny/crossref_metadata_2025 huggingface dataset:
Epigenetic regulator UHRF1 suppressively orchestrates multiple pathogenesis in rheumatoid arthritis.
Authors: Imai Yuuki , Saeki Noritaka , Inoue Kazuki , Ideta-Otsuka Maky , Watamori Kunihiko , Mizuki Shinichi , Takenaka Katsuto , Igarashi Katsuhide , Miura Hiromasa
Published: March 2021

Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation with aberrant epigenetic alterations, eventually leading to joint destruction. However, epigenetic regulatory mechanisms underlying RA pathogenesis remain largely unknown. Here, we showed that Ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) , a key molecule involved in maintenance of DNA methylation during cell division, is a central epigenetic regulator that orchestrates the suppression of expression of multiple factors that exacerbate RA. We found that murine arthritis tissue and human RA tissue, particularly synovial fibroblasts (SF), exhibit remarkable up-regulation of expression of Uhrf1. SF-specific Uhrf1 conditional knockout mice showed more severe arthritic phenotypes and apoptosis-resistant SF. Integrative analysis of the transcriptome and methylome showed that expression of several cytokines including Ccl20 was up-regulated in Uhrf1-deficient SF. In RA patients, disease activity scores, CCL20 expression, Th17 accumulation and apoptosis resistance were negatively correlated with UHRF1 expression in synovium. Finally, stabilization of UHRF1 by Ryuvidine administration diminished disease pathogenesis in arthritis model mice. Our results demonstrated that UHRF1 expressed in SF can contribute to suppression of multiple pathogenic events associated with RA such as Th17 recruitment, SF apoptosis and bone destruction, suggesting that targeting UHRF1 could represent a novel therapeutic strategy for RA.
A VENEZUELAN ANATOMIST CITED IN THE HUMAN ANATOMY TREATISE TESTUT-LATARJET
Authors: Romero-Reverón Rafael
Published: March 2021

Le traité d'anatomie Testut-Latarjet (The human anatomy Testut-Latarjet treatise) published in 1887, is considered one of the most complete on human anatomy, with detailed descriptions of the human body and anthropological concepts, accompanied by philosophical and anthropological concepts. This anatomy treatise is still a very useful teaching tool in many Latin American and European Medical Faculties. In 1902, this anatomical treatise won the Saintour Prize, awarded by the French Academy of Medicine and since 1910 it has been translated into Spanish, Italian, German and other languages. The Testut-Latarjet treatise on human anatomy consists of four volumes with a total of 4,935 pages in its 1960 Spanish edition, as well as 4,144 highly detailed illustrations in color. The 1960 Spanish edition of Testut-Latarjet treatise in its volume IV included a citing of the doctoral thesis: El elemento nervioso en el apendice libre. Sus aplicaciones quirurgicas (External innervation of the cecal appendix: its surgical applications) written in 1943 by Rubén Rodríguez Escovar, M. D., a Venezuelan anatomist and surgeon, who held the Department of Human Anatomy at the Universidad Central de Venezuela, distinguishing himself as teacher and researcher over a period of 40 years. Certainly, Rubén Rodriguez Escovar is not in the greatest group of prominent anatomists mentioned in the Treatise. Nevertheless, on merit alone for his research about meso-appendicular region’s innervations, he was cited into Testut-Latarjet‘s treatise. As far as the present author knows, Rubén Rodriguez Escovar is the sole Non-European anatomist to be mentioned in the outstanding Testut-Latarjet Human Anatomy Treatise.
Corporate social responsibility practices of business firms in Dubai during the COVID-19 pandemic
Authors: Mousa Eltoum Abubaker , Yatiban Aminurraasyid , Omar Rusdi , Islam Rabiul
Published: March 2021

During the first quarter of 2020, COVID-19 spread worldwide, claiming lives of thousands of people every day. This marked the beginning of all emergency and business continuity plans around the world. This study attempts to study people’s awareness of CSR practices among business firms in Dubai and investigate people’s evaluation of these CSR practices during the COVID-19 pandemic. The study employs a quantitative research method and mainly uses questionnaires for data collection. 199 respondents are selected from different business firms in Dubai. Expert interviews are also conducted for triangulation purposes. It involves the Dubai community with various backgrounds and status. This study shows that a large scheme of the Dubai community has a decent level of expertise in sustainability and corporate social responsibility. It also shows that firms that have implemented CSR before the crisis will mostly be better suited to play a supportive role for government and society during the crisis. AcknowledgmentResearch grant provided by the Fundamental Research Grant Scheme [FRGS/1/2017/SS01/UUM/02/23] under Ministry of Higher Education, Malaysia, and University Utara Malaysia (SO Code: 13806) is gratefully acknowledged.
Effectiveness of a Lockdown Policy During a Global Pandemic
Authors: Shih Yung Chin
Published: March 2021

Background:

In 2020, when the World Health Organization (WHO) declared COVID-19
(Coronavirus disease 2019) a pandemic, many of the public managers faced challenging situations
in their cities due to the simultaneous loss of lives and jobs. In this regard, this study aims to propose
a concise model that considers variables like the number of deaths, lethality of the virus, number
of jobs, and taxes collected by city halls. Our study considers these issues in providing a relevant
response and consistent answer to deliberations on the way forward.

Methods:

Mathematical modeling was used to analyze the interaction between the agents involved,
and computer simulation was chosen to collect results.

Results:

Changing the lockdown level (fixed and variable), the results of number of deaths per
week, the total number of unemployed, cost of companies, and so on are shown.
The levels of lockdowns adopted are: fixed (0%, 40%, 80%, 100%) and variable (30% to 60% and
80% to 40%).

The results show that for the input data considered, the 0% lockdown (LD) policy is more effective
for the economy and tax collection and also succeeds in repressing the effects on the number of
deaths. The comparison between with pandemic and without pandemic is provided (in percentage).

Adopting a 0% LD, it appears to be worse in couple of weeks compared to other LD levels with regard
to the percentage increase in the number of deaths due to the pandemic virus (in particular, +
626% for the 4th week while + 398% for 100% LD). Fortunately, in absolute numbers this quantity
is considered low in relation to the size of the population. The great advantage is seen mainly in tax
collection and number of unemployment generated. For a 0% LD, in the worst scenario, the tax collection
is reduced by 23.68% in the 8th week, while the worst (100% LD) the drop in tax collection
reaches 91.70%. The highest percentage of unemployed generated for 0% LD occurs is in the 16th
week, and for the worst LD (100%), the percentage of generation of unemployed number reaches
106.64%. The number of deaths caused by unemployment, for the worst case of 0% LD also occurs
in the 16th week, with 46.65% while for the 100% LD, the percentage of deaths has increased by
97.48%.

Conclusion:

This study shows that implementing the lockdown did not bring expected benefits, because
instead of reducing the number of deaths due to the COVID-19, individuals tend to die more
from other causes.
Effect of miRNAs, Proinflammatory Cytokines and ACE2 in COVID-19 Pathophysiology
Authors: Singh Hari Om , Jakhar Kamini , Nema Vijay , Krishnaraj Asha , Choudhari Ranjana
Published: March 2021

Background:

Angiotensin-converting enzyme 2 (ACE2) is the main cellular receptor for
the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and acts as a pro-inflammatory
mediator of Coronavirus disease (COVID-19). The clinical outcome of SARS-CoV-2
infection is influenced by the pro-inflammatory mediators. The specific microRNAs (miRNAs) influence
the ACE2 expression and are accountable for the increased circulatory pro-inflammatory
mediator levels. Thus, host factors play a crucial role in COVID-19 pathophysiology. The pathogenesis
of COVID-19 disease is not well understood. Hence we comprehended the role of miRNAs,
pro-inflammatory cytokines, and ACE2 genes in COVID-19 pathophysiology.

Methods:

We utilized multiple databases, specifically EMBASE, PubMed (Medline), and Google
Scholar, for our search.

Discussion:

SARS-CoV-2 genes could be the target of host miRNAs. The miRNAs regulate the expression
of ACE2 in various organs, including the kidney, heart, blood vessels, and lung. ACE2
acts as a pro-inflammatory mediator of SARS-CoV-2 associated disease. Pro-inflammatory cytokines
(IL-6, IL-1β, and TNF) have been associated with severe COVID-19 disease. Hence variation
in expression of miRNAs would influence the regulation of COVID-19 pathophysiology. The
clinical outcomes of COVID-19 are variable which could be linked with the difference in binding
of host miRNA to the target genes.

Conclusion:

Correlation of these genes with severe or critical stages of patients will provide biomarkers
for the severity of lung inflammation which would be useful in the rapid identification of
patients in need of hospital admission. Analysis of the relationship between the miRNAs and ACE2
will be helpful in designing anti-miR therapy for ACE2-related SARS-CoV-2 infection.
Religious Tolerance as a Law and Practice (in Islam and Orthodoxy)
Authors:   Don State Agrarian University, Andrew Fedorovich Polomoshnov , Platon Andreevich Polomoshnov ,   Rostov State University of Economics
Published: March 2021

The article analyzes the concept of religious tolerance in the context of the relationship be-tween its legal support and the practice of interfaith relations. Tolerance is viewed as one of the key principles of modern policy and practice of interfaith relations in the Russian poly-confessional religious community in close connection with the principles of freedom of con-science and confessional equality. The measure of religious tolerance is social loyalty and hu-manistic potential of a particular religious denomination. The historical origins of religious toler-ance in Islam and Orthodoxy, as well as pre-revolutionary, Soviet and modern Russian models of interfaith relations and religious politics are investigated. The characteristic of the legislative base of the modern Russian model of religious tolerance is given. Tolerance as a norm of inter-faith relations is considered on three levels. At the level of individual religious behavior of be-lievers, religious tolerance is manifested as a loyal attitude towards non-believers and atheists. At the level of interchurch relations of confessions, tolerance is realized as an orientation towards the inter-confessional world, dialogue and cooperation of confessions in maintaining the socio-cultural stability of Russian society. At the level of the religious policy of a poly-confessional state, religious tolerance is viewed in the context of the flexible, situational implementation of the principles of freedom of conscience, confessional equality, as well as ensuring effective co-operation between traditional churches and the Russian state in improving the spiritual potential and social stability of Russian society. The authors state that religious tolerance is an ultimate principle for modern spiritual situation in the Russian Federation although there is not complete correspondence between its legislative declaration and the real practice of interfaith relations. The task of state policy in the field of religion is to optimize interfaith relations in the country, relying on the support and organization of effective dialogue and cooperation between church organizations of traditional Russian confessions, both at the regional level and at the level of their central, governing bodies.
The phenomenon of Jihad in Islam
Authors:   Dagestan State University, Mukhtar Yakhyaevich Yakhyaev , Yakhaev Arsen Mukhtarovich
Published: March 2021

Based on a critical analysis of the definitions of Jihad in popular science, dictionary refer-ence, commentary, and educational literature, the article establishes the methodological flaw of the abstract, one-sided representation of Jihad exclusively as a call to Muslims to wage a "Holy war". It concludes that such a one-sided definition of Jihad, imposed on the world community by Western Islamism, which is critical of everything Muslim, is used by the inspirers of interna-tional terrorism as a religious justification for the need to wage an armed war against non-believers and apostates. Understanding the Quranic provisions about Jihad, the historical en-richment of the content of Jihad, the various forms and varieties of its manifestation allows the authors to outline methodologically verified research principles and offer a conceptual defini-tion of Jihad that expresses its deep essence. The article defines Jihad as an Islamic phenome-non that consists in the concentration of consciousness, will, desires, and efforts of every Mus-lim and the entire Islamic Ummah in General to strengthen the faith in the One Allah, to protect and spread this faith, and to subordinate personal and public life to the requirements of Islam. This deep essence of Jihad is manifested in the most diverse efforts made by believers on the path of Islam, in the zeal that contributes to the qualitative improvement of the Muslim Ummah, its quantitative growth. The author of the article considers it inappropriate to claim that the religious phenomenon named by the Arabic term "Jihad" is exclusively an Islamic phenomenon. He puts forward the thesis that, although the term "Jihad" is used only in Islam to express the concentration of all ef-forts of Muslims on the path of establishing faith in the One Allah, a similar phenomenon occurs in other religions. The selfless service of Muslims to Islam should not become the basis for its characterization as a bloodthirsty religion associated with wars, battles, violence, suicides, and other negative aspects, since no religious and cult system can be established, strengthened, and spread except on the basis of the diligent service of its adherents.
At the Origins of Dagestan Philosophy and Islamic Studies (to the 90th anniversary of the birth and 70th anniversary of the scientific, pedagogical and social activities of M.A. Abdullaev)
Authors:   Dagestan State Medical University, Telman Emiralievich Kafarov
Published: March 2021

The article highlights some important philosophical and Islamic views and works of the famous Russian, Dagestani scientist Abdullaev Magomed Abdullayevich, in connection with his 90th anniversary of the birth and 70th anniversary of scientific, pedagogical and social activities. The author notes the importance and relevance of the problems raised in numerous monographs and articles, especially the specifics of Islam in the Caucasus and Dagestan, and the uniqueness of regional Sufism. Thanks to the works of Magomed Abdullayevich, the original views of doz-ens of thinkers representing the multinational Republic were preserved in historical memory. It is emphasized that he is not only an academic scientist, but also a publicist whose works on topical religious issues played a constructive role in particularly dramatic periods of the development of our country and our republic. Overcoming the stereotypes in assessing Islam that formed during the Soviet period of the county’s development, he shows that it is an integrating factor for the entire culture and life of Dagestanis.
Strategi pengembangan lulusan Departemen Manajemen Institut Pertanian Bogor melalui tracer study
Authors: Mochammad Rachmawaty , Kartika Lindawati
Published: March 2021

Institut Pertanian Bogor konsisten dalam mempertahankan peringkat universitasnya di tingkat internasional maupun nasional. Lulusan dengan IPK yang baik dan memiliki kompetensi tinggi sangat dibutuhkan dalam memasuki pasar kerja. Tujuan dari penelitian untuk: 1) menganalisis hubungan masa tunggu pekerjaan dengan prestasi akademik dan relevansi pekerjaan lulusan Departemen Manajemen IPB, 2) menganalisis aspek pengetahuan dan keterampilan yang menjadi prioritas dalam kebutuhan pekerjaan sekarang dan relevansinya terhadap kompetensi lulusan Departemen Manajemen IPB. Data yang digunakan adalah data primer yang diperoleh melalui kuesioner dan data sekunder dari data akademik Departemen Manajemen IPB. Metode yang digunakan adalah analisis deskriptif, CHAID, IPA dan Net Promoter Score. Lulusan dengan IPK yang baik memiliki masa tunggu pekerjaan cepat dan bidang pekerjaannya memiliki kesesuaian/ relevansi dengan ilmu yang dipelajari. Hasil analisis IPA menunjukkan yang menjadi fokus utama dalam perbaikan kompetensi lulusan Departemen Manajemen IPB adalah kompetensi yang berada pada kuadran concentrate here yaitu pengembangan diri, creativity serta judgement and decision making.
Nilai-nilai dan metode pendidikan karakter di taman kanak-kanak di Banjarmasin
Authors: Siswoyo Dwi , Rukiyati Rukiyati , Hendrowibowo L
Published: March 2021

Masa usia dini adalah masa yang tepat untuk dikenalkan, dan ditumbuhkan pendidikan moral agar kelak anak menjadi orang yang baik. Selain orang tua, guru memgang peran penting untuk mengembangkan nilai-nilai moral dalam diri anak usia dini di Taman Kanak-Kanak. Tujuan penelitian ini adalah untuk : 1)  menganalis nilai-nilai karakter  yang menjadi target pendidikan karakter di Taman Kanak-Kanak di kota Banjarmasin; 2) menganalisis metode penanaman nilai karakter yang diterapkan di taman kanak-kanak di kota Banjarmasin. Penelitian ini menggunakan pendekatan deskriptif kualitatif dengan metode pengumpulan data berupa diskusi grup terfokus (focus group discussion). Subjek penelitian ini terdiri dari 30 orang guru TK ‘Aisyiyah di kota Banjarmasin. Analisis data mengikuti langkah-langkah Miles Huberman meliputi, reduksi data, penyajian data dan penarikan kesimpulan. Uji keabsahan data dengan trianggulasi sumber. Hasil penelitian menunjukkan bahwa ada delapan nilai utama yang dikembangkan guru, yaitu religiusitas, respek (hormat menghormati), kemandirian, percaya diri, kejujuran,  disiplin, tanggung jawab, dan kerjasama.   Metode yang digunakan guru adalah keteladanan, pembiasaan, memberi nasehat, bercerita dan sosiodrama, kunjungan sosial, fasilitasi, bernyanyi, pengenalan dan hafalan  hadis singkat. Evaluasi pendidikan moral dilakukan sesuai yang tercantum di dalam kurikulum TK, yaitu menggunakan observasi perilaku anak sehari-hari. Sebagian besar anak telah mencapai perkembangan moral yang baik, dan  beberapa anak mendapat nilai sangat baik. Perilaku moral yang paling tampak perkembangannya adalah kemandirian dan rasa percaya diri. Anak  telah dapat membaca kitab suci Alquran, dan menghafal beberapa hadis pendek.
Pengaruh self efficacy dan pengasuhan orang tua terhadap kepercayaan diri siswa
Authors: Pangestu Chairunnisa , Sujati Hieronimus , Herwin Herwin
Published: March 2021

Penelitian ini bertujuan untuk mengetahui secara parsial pengaruh self efficacy terhadap sikap percaya diri, mengetahui secara parsial pengaruh pengasuhan orang tua terhadap sikap percaya diri, serta mengetahui secara simultan pengaruh self efficacy dan pengasuhan orang tua terhadap sikap percaya diri. Penelitian ini menggunakan pendekatan kuantitatif dengan metode ex-post facto. Populasi dalam penelitian ini adalah siswa SD se-Kecamatan Kotagede, Yogyakarta yang berjumlah 3941 siswa dengan sampel penelitian berjumlah 363 siswa yang ditentukan dengan Metode Slovin. Teknik pengumpulan data menggunakan skala kepercayaan diri, skala self efficacy, dan skala pengasuhan orang tua. Uji prasyarat analisis menggunakan uji normalitas, uji linearitas dan uji multikolinearitas. Teknik analisis data yang digunakan adalah korelasi parsial dan regresi ganda. Hasil penelitian menunjukkan bahwa self efficacy secara parsial berpengaruh signifikan terhadap kepercayaan diri siswa, pengasuhan orang tua secara parsial berpengaruh secara signifikan terhadap kepercayaan diri siswa, serta self efficacy dan pengasuhan orang tua secara simultan berpengaruh signifikan terhadap kepercayaan diri siswa dengan sumbangan sebesar 35,5%.Kata kunci: self efficacy, pengasuhan orang tua, percaya diri
Perekayasaan sistem pendidikan nasional untuk mencerdaskan kehidupan bangsa
Authors: Hermanto Bambang
Published: March 2021

Artikel ini menganalisis kebijakan pendidikan di Indonesia. Sistem pendidikan nasional harus mampu menjamin pemerataan kesempatanpendidikan, peningkatan mutu serta relevansi dan efisiensi manajemen pendidikan untukmenghadapi tantangan sesuai dengan tuntutan perubahan kehidupan lokal, nasional, danglobal sehingga perlu dilakukan pembaharuan pendidikan secara terencana, terarah, danberkesinambungan.Metode yang digunakan dalam penelitian ini adalah analisis media dan studiliteratur.Teknik pengumpulan data yang digunakan berasal dari data primer yang berupa observasi atas fenomena yang terjadi dan data sekunder berupa dokumentasi yang valid.  Hasil analisis menunjukkan bahwa Penerapan sistem pendidikan nasional yang baik dan mencerahkan bagi peserta didik tidak denganmeliberalkan sistem pendidikan, tetapimembangun pemikiran bahwa tidak selalu pemerintah, orang tua dan guru lebih tahu yang terbaik bagi peserta didik. Kementerian Pendidikan dan Kebudayaan, serta Kementerian Riset Teknologi dan Pendidikan Tinggi perlu melakukanreformasisecara komprehensifterkaitdenganpelaksanaansistem pendidikannasionaldengancarayangefisien,transparan,dan akuntabel. Pendidikan harus mendapatkanperhatian yang serius bagi setiap bangsa,karena dengan pendidikan akan dapatdilihat maju mundurnya suatu bangsa.Tentu saja bangsa Indonesia tidak ingin hidup terbelakang akibat aspek pendidikantidak mendapat porsi yang cukup dengan beriringnya berbagai kemajuan di bidanglain. Sehingga penting suatu perekayasaan sistem pendidikan nasional untuk mencerdaskan kehidupan bangsa.Kata kunci: Perekayasaan, Kehidupan Bangsa, Mencerdaskan, Sistem Pendidikan Nasional
Feokromocitom: put od prvih simptoma do dijagnoze
Authors: Marušić Romana , Turk Tajana , Degmečić Dunja , Bačun Tatjana
Published: March 2021

Cilj: Prikazati slučaj pacijenta obrađenog zbog gubitka na tjelesnoj masi i anksioznosti kojemu je utvrđen tumor srži nadbubrežne žlijezde, a naknadnim uvidom u medicinsku dokumentaciju utvrđene su i višegodišnje povremene palpitacije, tahikardije i skokovi tlaka. Prikaz slučaja: Prikazan je šezdesetdvogodišnji pacijent koji se žalio na oslabljen apetit unatrag 3 mjeseca, gubitak na tjelesnoj masi 10 kg te anksioznost. Ultrazvukom abdomena utvrđena je, a kompjutoriziranom tomografijom (CT) abdomena potvrđena, oštro ograničena heterogena tvorba desne nadbubrežne žlijezde promjera 4,2 x 5 cm i denziteta 26 Hounsfieldovih jedinica. Iz medicinske dokumentacije saznaje se da je prethodnih 4 godina povremeno imao palpitacije i supraventrikularne tahikardije s vrijednostima krvnog tlaka do 190/100 mmHg. Endokrinološkom obradom utvrđene su povišene vrijednosti metanefrina i normetanefrina u plazmi (12 i 9 puta). Nakon operacije patohistološki je potvrđena dijagnoza feokromocitoma. Kontrolni nalazi metanefrina i normetanefrina bili su uredni. Planira se kontrola metanefrina i normetanefrina u plazmi jedanput godišnje. Zaključak: U ovom prikazu slučaja želi se istaknuti važnost postavljanja sumnje i pravovremenog utvrđivanja feokromocitoma te sprječavanja mogućih komplikacija. Ako postoji klinička sumnja na feokromocitom ili je tijekom obrade incidentaloma nadbubrežne žlijezde CT-om isključeno da se radi o adenomu, potrebno je učiniti biokemijsku obradu feokromocitoma. Ako se ne prepoznaju na vrijeme, ovi tumori zbog svoje hipersekrecije katekolamina imaju visok kardiovaskularni morbiditet i mortalitet.
Acceptability, Safety, and Resonance of the Pilot Digital Suicide Prevention Campaign “Better Off With You”: Qualitative Study (Preprint)
Authors: Carrotte Elise Rose , Webb Marianne , Flego Anna , Vincent Bonnie , Heath Jack , Blanchard Michelle
Published: March 2021

BACKGROUND

The Interpersonal Theory of Suicide posits that there are three key elements of suicidal behavior: perceived burdensomeness, thwarted belongingness, and the acquired capability for suicide. The digital campaign Better Off With You was developed to directly challenge the idea of perceived burdensomeness among people who are contemplating suicide in 2 communities within Australia.

OBJECTIVE

The aim of this study is to explore the needs and preferences of people with lived experience of suicidal thoughts and actions to inform the development of Better Off With You.

METHODS

This study involved a series of focus groups that aimed to discuss campaign messaging, scope, and approach. People with lived experience of suicidal thoughts and actions attended the focus groups. After the completion of initial focus groups, the results informed the creation of campaign collateral by creative agencies. Early versions of the campaign collateral were then presented in the user testing sessions. Transcriptions were analyzed via thematic analysis.

RESULTS

In total, 13 participants attended the focus groups and 14 attended the user testing sessions. The following three overarching themes were presented: acceptability, safety, and resonance. Participants believed that suicide is a serious and ongoing issue in their communities and welcomed a localized suicide prevention focus via peer-to-peer storytelling. The idea of perceived burdensomeness required clarification but was perceived as acceptable and relevant. Participants seemed drawn toward peer narratives that they perceived to be authentic, genuine, and believable as given by real people with lived experience. Campaign messaging needs to be clear and empathetic while directly talking about suicide. Participants did not anticipate any significant negative or harmful impact from any campaign videos and highlighted the importance of providing appropriate help-seeking information.

CONCLUSIONS

This iterative study provided important insights and knowledge about peer-to-peer storytelling in suicide prevention campaigns. Future campaigns should involve simple messaging, be validating and empathetic, and consider including a lived experience perspective.
The Goddess on the Vezirhan Stele
Authors: Kisbali Tamás Péter
Published: March 2021

The stele from Vezirhan (Istanbul Archaeological Museum, inv. 6219+71.27) is best known for its Old Phrygian and Greek inscriptions (B-05). However, its reliefs also pose an interesting challenge. They include a boar hunt, a ritual banquet scene, and a human figure, commonly identified as a goddess, with lions, birds, and a palmette-like motif “sprouting” from her head.

The stele is dated to the late 5th–early 4th century BC. The hunt and banquet scenes clearly belong to this time (and find many parallels on votive and funerary reliefs and seals of Hellespontine Phrygia).

The image of the goddess, however, continues a different tradition, one that possibly stems from an earlier period. The Vezirhan goddess doesn’t have a singular prototype, but displays connections to a wide variety of iconographical schemes and details. Most are found in the 7th–6th centuries BC arts of Anatolia and the Aegean. By examining this corpus, with special focus on the Potnia theron iconographic type, we understand that the Vezirhan goddess is related to other deities attested in Anatolia (in fact, her name might have been a variation of Artemis, according to line 3 of the Phrygian inscription). Yet, she cannot be identified with any of them directly. For all matches, there are also differences. A certain creative effort was made to distinguish the goddess from her peers, possibly to reflect her local cult.

In my talk, I would like to unfold this synthetic image, examine its components, and try to put them back together – and hopefully gain some insight into how the Vezirhan goddess’ iconographic scheme came to be.
Images of the arXiv: Reconfiguring large scientific image datasets
Authors: Tan Kynan , Munster Anna , Mackenzie Adrian
Published: March 2021

In an ongoing research project on the ascendancy of statistical visual forms, we have been concerned with the transformations wrought by such images and their organisation as datasets in ‘re-drawing’ knowledge about empirical phenomena. Historians and science studies researchers have long established the generative rather than simply illustrative role of images and figures within scientific practice. More recently, the deployment and generation of images by scientific research and its communication via publication has been impacted by the tools, techniques, and practices of working with large (image) datasets. Against this background, we built a dataset of 10 million-plus images drawn from all preprint articles deposited in the open access repository arXiv from 1991 (its inception) until the end of 2018. In this article, we suggest ways – including algorithms drawn from machine learning that facilitate visually ’slicing’ through the image data and metadata – for exploring large datasets of statistical scientific images. By treating all forms of visual material found in scientific publications – whether diagrams, photographs, or instrument data – as bare images, we developed methods for tracking their movements across a range of scientific research. We suggest that such methods allow us different entry points into large scientific image datasets and that they initiate a new set of questions about how scientific representation might be operating at more-than-human scale.
Aplikasi Simulator Algoritma Penjadwalan Central Processing Unit Menggunakan Actionscript 3.0
Authors: Putra Edson Y. , Sandag Green A. , Djimesha Enrico S.
Published: March 2021

Teknologi pada zaman ini telah berkembang dengan pesat, khususnya teknologi Central Processing Unit. Karena itu, manusia dituntut untuk mempelajari cara kerja Central Processing Unit. Central Processing Unit itu sendiri memiliki banyak fungsi, salah satunya adalah melakukan pemrosesan, dimana terdapat antrian proses yang akan dieksekusi. Sayangnya, metode pembelajaran mengenai antrian Central Processing Unit masih kurang efektif karena hanya menggunakan Gantt Chart sebagai gambaran untuk cara kerjanya. Ini menyebabkan peneliti bermaksud untuk melakukan perancangan aplikasi simulator berbasis desktop untuk membantu para pelajar agar lebih mudah memahami dengan memberikan gambaran secara animasi mengenai cara kerja antrian proses yang terdapat pada Central Processing Unit, khususnya antrian dengan algoritma First-Come-First-Served dan nonpreemptive Shortest-Job-First. Pada perancangan aplikasi ini, peneliti menggunakan perangkat lunak Adobe Flash Professional CC 2015 dengan bahasa pemrograman ActionScript 3.0.
KLASIFIKASI ASPIRASI MAHASISWA DENGAN NAIVE BAYES CLASSIFIER
Authors: Rizqa Ifan
Published: March 2021

Aspirasi mahasiswa adalah berbagai tuntunan dari mahasiswa yang dikemas dalam ide kreatif  untuk mengusulkan proses perubahan atas suatu hal. Rata-rata aspirasi yang disampaikan berupa keluhan dan harapan. Aspirasi berguna sebagai bahan evaluasi dan deteksi dini terhadap kelemahan sistem kualitas perguruan tinggi menjadi lebih baik. kegiatan ini terjadi di UDINUS, DPM sebagai pihak yang mengelola aspirasi mahasiswa. Aspirasi didapatkan melalui sebuah mekanisme yang telah ditentukan seperti penyebaran kuisioner secara manual atau berbasis google form.  Kuisioner yang disediakan mengharuskan mahasiswa mengisi isi aspirasi sesuai katagori yang disediakan. Namun, permasalahan yang dihadapi terkadang mahasiswa salah memilih katagori sesuai isi aspirasi yang ditulis. Maka dari itu perlu dibuat sistem yang dapat mengkatagorisasikan aspirasi mahasiswa secara otomatis. Klasifikasi teks dokumen menjadi cara yang paling baik untuk menentukan katagori berdasarkan isi aspirasi mahasiswa. Metode Naïve Bayes Classifier digunakan karena mampu menghasilkan akurasi yang tinggi. Dengan 1000 dokumen data latih yang masing-masing 250 dokumen setiap katagori yaitu “Sarana dan Prasarana”, “Dosen”, “Kepegawaian dan Sistem Akademik”,”Saran dan Masukan” menghasilkan akurasi 90.20%. Dapat dikatakan metode ini layak implementasi dalam penelitian ini.      
IMPLEMENTASI STAR SCHEMA DALAM PEMBANGUNANAN DATA WAREHOUSE PENJUALAN PRODUK TOUR
Authors: Triandini Evi , Rijal Muhammad Syamsu , Ambara Made Pradnyana
Published: March 2021

Salah satu factor yang mendukung kemajuan sebuah perusahaan adalah kemampuannya untuk menganalisa pasar dengan baik. Perilaku konsumen harus mampu ditangkap dengan baik oleh perusahaan, sehingga menajerial dapat mengevaluasi dan menganalisa untuk menghasilkan kebijakan strategis. Data warehouse bisa dijadikan sebagai solusi baru untuk mengatasi permasalahan manajemen terkait dengan informasi penjualan dari waktu ke waktu. Permasalahan yang akan diselesaikan dalam penelitian ini yaitu bagaimana mengimplementasikan data warehouse untuk mengelola data penjualan produk tour dalam beberapa periode? Tujuan penelitian ini yaitu menghasilkan aplikasi data warehouse yang mampu memberikan informasi yang diperlukan oleh perusahaan untuk menentukan kebijakan strategis. Penelitian ini akan menggunakan Nine Steps Design Methodology dari Ralph Kimball untuk merancang skema data warehouse. Sedangkan skema pemodelan dimensional yang digunakan adalah Star Schema, dikarenakan kecepatannya dalam proses pemanggilan data. Penelitian telah menghasilkan sistem data warehouse penjualan produk tour yang menampilkan informasi penjualan produk tour menggunakan grafik dan dilengkapi detil data jika diperlukan untuk dilihat. Sistem juga memberikan kemudahan bagi pengguna untuk melihat data sesuai dimensi yang diperlukan misalkan dimensi client, vendor dan category. Hal ini memudahkan manajemen untuk mengetahui sebaran penjulan produk sesuai dengan dimensi tersebutmenampilkan informasi yang diperlukan oleh manajemen.
Rancang Bangun Aplikasi Investasi UKM Berbasis WEB Dengan Fitur Penentuan Resiko Bisnis
Authors: Ananda Putra Tri
Published: March 2021

Pada kondisi ekonomi saat ini yang terus berkembang dan meningkatnya kebutuhan yang harus dipenuhi, memberikan dampak bagi masyarakat kecil dan menengah untuk membuka sebuah usaha. Namun ketidaksediaan modal membuat hambatan dalam mengembangkan bisnis yang dijalankan tersebut. Sementara sebagian masyarakat yang lainnya menginginkan sebuah pendapatan tambahan dengan ikut investasi pada bisnis yang dijalankan namun belum memiliki jalan untuk itu. Pemanfaatan teknologi informasi saat ini dapat menjadi solusi bagi permasalahan diatas, yaitu dengan membuat sebuah aplikasi investasi ukm yang berjalan pada platform berbasis WEB. Aplikasi ini dapat mempertemukan investor yang dapat urunan dana modal yang dilengkapi informasi resiko dari bisnis yang diajukan oleh owner. Dengan adanya sistem aplikasi ini dapat meningkatkan pertumbuhan ekonomi di masyarakat khususnya masyarakat kecil dan menengah. Aplikasi ini dibangun dengan menggunakan bahasa pemrograman PHP dan framework Laravel serta basis data MySQL. Fungsi utama pada aplikasi ini adalah investor dapat membeli sebuah bisnis yang sudah diajukan oleh owner dengan tambahan informasi resiko bisnis hasil pengolahan menggunakan algoritma SAW (Simple Additive Weighting). Fungsi informasi resiko bisnis dapat membantu investor dalam pertimbangan sebelum membeli sebuah bisnis pada aplikasi ini.
Youth Voting, Rational Competency, and Epistemic Injustice
Authors: Baumtrog Michael
Published: March 2021

In 1970 the voting age in Canada changed from 21 to 18. Since then, there have been calls to lower it further, most commonly to age 16. Against the motion, however, it has been argued that youth may lack the ability to exercise a mature and informed vote. This paper argues against that worry and shows how restricting youth from voting on the basis of a misbelief about their abilities amounts to an epistemic injustice.
Global weak solution to a generic reaction-diffusion nonlinear parabolic system
Authors: Hana Matallah , MAOUNI MESSAOUD , Lekhal Hakim
Published: March 2021

We consider a new generic reaction-diffusion system, given as the
following form: ∂u/∂t - div(g(│(∇u_σ)│)∇u)=f(t,x,u,v,∇v), in Q_T ∂v/∂t
- d_v Δv=p(t,x,u,v,∇u), in Q_T u(0,.)=u_0, v(0,.)=v_0, in Ω (1)
∂u/∂η=0, ∂v/∂η=0, in ∑_T. Where Ω=]0,1[?×]0,1[, Q_T =]0,T
[? and T =]0,T [?, (T > 0), η is an outward normal to
domain Ω and u_0, v_0 is the image to be processed, x ∈Ω, σ
>0, ∇u_σ= u∗ ∇G_σ and G_σ= 1/√2πσ exp(-│x│^2/4σ). In
this study we are going to proof that there is a global weak solution to
the ptoblem (1), we truncate the system and show that it can be solved
by using Schauder fixed point theorem in Banach spaces. Finally by
making some estimations, we prove that the solution of the truncated
system converge to the solution of the problem.
Cardiac resynchronization therapy: Interventricular delay during ventricular and supraventricular tachyarrhythmia
Authors: Stroobandt Roland , Kucher Andreas
Published: March 2021

Abstract Introduction Implantable cardioverter-defibrillators (ICDs) for
cardiac resynchronization therapy (CRT-D) with the capability of LV
sensing enable the assessment of interventricular delays in ventricular
(VT) and supraventricular tachycardias (SVT). Methods and Results In
total, 1078 EGM recordings of VT or VF episodes were investigated that
have been transmitted via Home MonitoringⓇ. Only those EGM recordings
showing the onset of the tachyarrhythmia were used for investigation. In
the 623 cases eligible for evaluation left-sided VTs could be identified
in 349 cases, right-sided VTs in 252 cases. SVTs with a 1:1 antegrade
conduction were found in 22 cases. VT can present three different
interventricular delays whereby the right-ventricular sensed event (RVs)
is either preceding the left-ventricular sensed event (LVs), or the LVs
is preceding RVs, or there can be a simultaneous occurrence of RVs and
LVs. In SVTs, either the LVs events were delayed or occurred
simultaneously with the RVs events. SVT cases with LVs preceding the RVs
events were not found. Conclusion The LV-EGM channel enables to
distinguish between left- and right-sided premature ventricular
complexes. The assessment of the interventricular delay in VTs is useful
to differentiate between a possible apical-, left- or right-sided origin
of the VT but not to identify SVTs. Key Words Implantable Cardioverter
Defibrillator (ICD), Cardiac resynchronization therapy (CRT), LV
sensing, RV sensing, Ventricular tachycardia, Supraventricular
tachycardia, Left bundle branch block, Heart failure, Interventricular
conduction delay
Three-Dimensional Echocardiographic Assessment of the Aortic Valve and the Aorta
Authors: Smer Aimen , Urja Prakrity , Anugula Dixitha , Dulal Subash , Elmarzouky Zeyad , Gill Edward , Nanda Navin
Published: March 2021

We describe the role of three-dimensional echocardiography in the
assessment of the aortic valve and the aorta. The manuscript is heavily
illustrated with figures and movie clips.
Sequential extraction studies on the river Tisa sediments for the assessment of the metal pollution
Authors: Strbac Snezana , Kasanin-Grubin Milica , Gajica Gordana , Mutic Jelena , Vasic Nebojsa
Published: March 2021

The sequential extraction procedure was applied for partitioning of metals in
river sediments collected along the course of the river Tisa (Serbia). Eight
elements (Sb, Sn, As, Cd, Cu, Hg, Pb and Zn) from twenty-one sampling site
were analyzed using the modified BCR sequential extraction procedure in
combination with ICP-OES. The results of sequential extraction, statistical
analyses and calculation of EF and lithogenic and anthro?pogenic ratio of
metals are similar. In the river Tisa sediments Sn, Cd, Hg, Pb and Zn are of
anthropogenic origin, while As, Cu and Sb are of lithogenic and
anthropogenic origin. The sediments from the river Tisa show high risk for
Cd, medium risk for Hg and Zn, low risk for Sn, As, Cu and Pb, whereas Sb
does not show the risk for the aquatic environment.
Trends in orthodontic management strategies for patients with congenitally missing lateral incisors and premolars
Authors: Naoum Steven , Allan Zjana , Yeap Chee Keong , Razza J. Mike , Murray Kevin , Turlach Berwin , Goonewardene Mithran S.
Published: March 2021

Objectives

To identify changes in orthodontic management strategies in patients with hypodontia seen in 2000, 2010, and 2017/2018 (during a 1-year period).

Materials and Methods

An assessment of the panoramic radiographs of 3701 patients from a Western Australian private practice identified 276 individuals demonstrating hypodontia. The location of missing teeth, age, sex, type of malocclusion, and the management strategies (space closure or opening) for each patient were noted.

Results

Most hypodontia involved agenesis of three or fewer teeth (90%). Maxillary lateral incisors and mandibular second premolars were the most commonly missing teeth. Female preponderance was noted. When considering treatment, the odds ratio for orthodontic space opening and prosthetic replacement in 2000 was 3.266 (P value = 7e-04; 95% confidence interval [CI], 1.464–4.633) compared with patients seen in 2010 and 1.632 (P value = 7e-04; 95% CI, 0.811–2.434) compared with patients in 2017/2018. For patients demonstrating bilateral absence of maxillary lateral incisors, the odds ratio for orthodontic space opening was 3.185 (P value = 0.0215; 95% CI, 1.182–9.243) compared with counterparts with unilateral agenesis. None of the factors investigated were significantly associated with the types of treatment planned/provided for the patients with missing mandibular second premolars.

Conclusions

Maxillary lateral incisors and mandibular second premolars were the most commonly missing teeth. A trend away from space opening and prosthetic replacement toward orthodontic space closure was observed from 2000 to 2017/2018. This may reflect a change in attitude toward prosthetic replacement options and/or greater optimism with biomechanical strategies since the implementation of temporary anchorage devices to assist in space closure.
IMPLEMENTASI KEBIJAKAN PEMBATASAN SOSIAL BERSKALA BESAR (PSBB) SEBAGAI UPAYA PENANGGULANGAN CORONA VIRUS DISEASE 2019 (COVID-19)
Authors: Herdiana Dian
Published: March 2021

Artikel ini membahas upaya pemerintah untuk mengatasi COVID-19 yang telah menyebar ke semua provinsi. Pemerintah pusat telah menetapkan COVID-19 sebagai bencana non-alami sehingga upaya penanggulangannya dikoordinasikan langsung oleh pemerintah pusat. PSBB dipilih oleh pemerintah sebagai upaya untuk mengatasi COVID-19 dan dilaksanakan di beberapa daerah yang memiliki kasus infeksi COVID-19 yang tinggi. Berdasarkan uraian di atas, tujuan artikel ini adalah untuk mengetahui bagaimana kebijakan PSBB diimplementasikan sebagai upaya untuk mengatasi COVID-19. Pendekatan kualitatif dengan metode analisis deskriptif digunakan sebagai metode penelitian. Hasil analisis menggunakan tiga indikator yaitu substansi kebijakan, para pelaksana dan kelompok sasaran menunjukan bahwa PSBB memiliki substansi kebijakan yang jelas dan telah dilaksanakan oleh para pelaksana dengan baik, tetapi masalahnya yaitu masyarakat sebagai kelompok sasaran tidak sepenuhnya mematuhi kebijakan PSBB yang disebabkan oleh tiga hal, yaitu kurangnya kesadaran masyarakat tentang kebijakan PSBB, keengganan masyarakat untuk mematuhi kebijakan PSBB dan ketidakmampuan masyarakat untuk mematuhi kebijakan PSBB.
REGISTRO DE FRUGIVORIA EM FURÃO-PEQUENO (GALICTIS CUJA) NO BRASIL
Authors: Schmitt Artur , Favretto Mario Arthur
Published: March 2021

O furão-pequeno (Galictis cuja) é um mamífero de pequeno porte nativo da América do Sul, é considerado uma espécie carnívora, alimentando-se principalmente de pequenos vertebrados. No presente estudo é realizado um registro de frugivoria realizada por G. cuja em Arabutã, no oeste de Santa Catarina, sul do Brasil. Galictis cuja foi registrado em filmagem de armadilha fotográfica alimentando-se de abacates (Persea americana). Os únicos registros de frugivoria nesta espécie que encontramos datam das décadas de 1950 e 1980 no Chile. Este registro indica o quão oportunista é esse mamífero e reforçam a importância de observações in situ para registros de alimentação de mamíferos.
مبررات إنتهاك القانون الدولي في مجال المساواة في السيادة
Authors: Abu Alqasim Layla I.
Published: March 2021

تتصدر القواعد القانونية الدولية مجموعة القواعد القانونية للمجتمع الإنساني، وذلك لخطورة المسائل التي تعنى بها بالنسبة للجماعات البشرية المختلفة.  بالرغم أنها تنبثق كلها ، وإن كانت بدرجات وطرق مختلفة من تعبير الدول السيدة عن إراداتها. وذلك سواء أرادت حقا الاعتراف بالطابع الإلزامي لقاعدة ما، أو نتيجة الالتزام  بالعلاقات الاجتماعية الدولية. ومبدأ المساواة في السيادة من القواعد القانونية ، التي تمثل أساس الألتزام  وقد يحدث انتهاك لهذه القواعد من بعض الدول، وتستمد المبررات من القوانين الدولية الحــديثة. فالكثير من عوامل الأنتهاك الخفي للقواعد القانونية الدولية، لايمكن الأعتراض عليه لكونه يتفق معها من الناحية النظرية، وتكون نتائجه غير مشروعة
علاقة التسويق عبر الهاتف المحمول بالمستخدمين الشباب
Authors: Zainal Bushra A.
Published: March 2021

تهدف هذه الدراسة إلى التعرف على مفهوم التسويق عبر الهاتف لكونه أحد أهم الموضوعات التي عادة مايتم الاغفال عنها من قبل منظماتنا لكون  معظمها لا يزال يعمل بالطريقة التقليدية، والهدف العملي الآخر هو قياس العلاقة بين التسويق عبر الهاتف المحمول والمستخدمين الشباب  باستخدام ادوات التحليل الإحصائية. تعتبر هذه الدراسة مهمة لكونها تتعامل مع أحد الموضوعات الحيوية في الوقت الحاضر والا وهي: كيفية تمكين استخدام التسويق عبر الهاتف المحمول في بيئتنا وعلاقته بقبول المستخدمين الشباب للتقنيات الحديثة للتسويق. لتحقيق أهداف الدراسة ، تم توزيع 87 استمارة استبيان على عينة عشوائية من مستخدمي الهواتف المحمولة ، وبعد ذلك قمنا بتحليل النتائج على برنامج SPSS ، وتم اختبار العلاقة بين كل من متغيرات الدراسة. يمكن تلخيص مشكلة البحث بأسئلة البحث التالية: هل يشعر جميع المستهلكين الشباب بالرضا تجاه إعلانات التسويق عبر الأجهزة المحمولة المستمرة التي يتم عرضها على هواتفهم المحمولة؟ هل تساعد إعلانات التسويق عبر الأجهزة المحمولة المستهلكين على اتخاذ قرار شراء صحيح؟ هل تساهم إعلانات التسويق عبر الأجهزة المحمولة في اقناع المستهلكين الشباب بتغيير قرار الشراء الخاص بهم من منتج إلى آخر؟ وانتهت الدراسة بمجموعة من الاستنتاجات ، أهمها وجود علاقة معنوية بين التسويق عبر الهاتف المحمول والمستهلكين الشباب. بناءً على الاستنتاجات التي توصلت إليها الدراسة ، تم التوصل إلى مجموعة من التوصيات، اهمها ضرورة اهتمام جميع الشركات ببناء بنية تحتية لإعلانات الهواتف المحمولة مرضية، لأن الهواتف المحمولة هي أسهل طريقة للبقاء على اتصال مع المستهلكين في الوقت الحاضر. وتحتاج الشركات إلى استخدام إعلانات موثوقة يتم عرضها للمستهلكين المستهدفين مصحوبة بتجارب حقيقية في استخدام المنتج أو الخدمة.
الطبيعة القانونية لالتزامات الكاتب العدل في صحة السندات الثبوتية في القانون العراقي
Authors: Smael Tahsin H. , Aziz Shahla M.
Published: March 2021

يعتبر توثيق وتنظيم السندات العمود الفقري من الناحية القانونية لكل نظام اقتصادي والضامن الأساسي للمتعاملين، لذا يتمتع هذا الأخير في كل المجتمعات بأهمية بالغة ومكانة هامة، بحيث قام المشرع العراقي بسن قانون خاص بذلك وهو قانون الكتاب العدول ذو رقم (33) لسنة 1998، واوكل مهام توثيق وتنظيم تلك السندات إلى شخص قانوني وسماه الكاتب العدل، واعطاه الثقة والمصداقية في اعماله، وهو يستمد سلطته من القانون، ويتمتع بحقوق وصلاحيات لا يتمتع بها الشخص العادي، أو غيره من الموظفين العدليين، ومنح للمحررات التي يحررها القوة التنفيذية والرسمية فهي واجبة التنفيذ بذاتها بغير حاجة إلى رفع دعوى واستصدار حكم بالحق الثابت فيها،  فإن التوثيق والتنظيم يساهم في تحقيق السلم الاجتماعي واستقرار المعاملات بين الأفراد هذا من جهة، ومن جهة أخرى فإن حدث خطأ من جانبه قد يترتب عليه المسؤولية القانونية، لأن الأعمال القانونية للكاتب العدل متنوعة بحيث تتشابك التزامات وواجبات الكاتب العدل الكثيرة على اصحاب العلاقة والمراجعين، فكان لابد من تحديد التزاماته ومعرفة مدى مسؤوليته ونوع الالتزام التي يفرضه القانون المدني في قيامه بواجباته المدنية وتحديد حسن النية لديه من ضمان توثيق المستندات من قبله ليكون أعماله العدلية ذات التوثيق ويبعث الأمان للمتعاملين مع الدائرة العدلية، ولهذا فان هدفنا هو بيان الطبيعة القانونية للالتزام المدني للكاتب العدل في صحة السندات الرسمية في القانون العراقي، ومتى يكٍون التزامه بتحقيق نتيجة أو ببذل عناية تمهيداً لتكييف مسؤوليته القانونية من عدمه.