bluuebunny/crossref_metadata_2025 huggingface dataset:
Initial predictors for short-term prognosis in anti-melanoma differentiation-associated protein-5 positive patients
Authors: Yang Qihua , Li Tianfang , Zhang Xin , Lyu Kunlong , Wu Shujun , Chen Yan , Liu Shengyun , Yu Zujiang
Published: December 2020

Background: Anti-melanoma differentiation-associated protein-5 (anti-MDA5) positive patients are characterized by the high mortality rate caused by interstitial lung disease (ILD). We conducted a retrospective study to summarize the clinical features and identify the initial predictors for death in anti-MDA5 positive patients.Methods: We designed a retrospective cohort of anti-MDA5 positive patients. The demographic and clinical data recorded on first admission, as well as the outcomes during the first six months follow-up, were collected. Predictors of rapidly progressive ILD (RPILD) and poor outcomes were calculated using logistic regression models and Cox proportional hazard regression models, respectively.Results: A total of 90 anti-MDA5 positive patients were included in this study. Eighty-one (90%) patients presented ILD on admission and 35 (38.9%) patients developed RPILD subsequently. During the first six months of follow-up, 22 (24.4%) patients died of respiratory failure at an average time of 6.6 ± 5.9 weeks. Factors including disease duration < 2 months (OR 6.1, 95% CI 1.7-22.4, P = 0.007), serum ferritin ≥ 1500 ng/ml (OR 12.3, 95% CI 3.1-49.6, P <0.001), CRP≥13mg/L (OR 4.6, 95% CI 1.3-16.9, P = 0.021) and total GGO score≥4 (OR 6.3, 95% CI 1.8-21.9, P = 0.003), were identified as independent predictors for RPILD. Cox regression model showed that total CT GGO score ≥ 4 (HR 4.8, 95% CI 1.3-17.9, P = 0.020), KL-6 > 1600 U/ml (HR 3.7, 95% CI 1.5-9.1, P = 0.004) and CRP > 5.8 mg/L (HR 3.7, 95% CI 1.0-12.8, P = 0.044) were poor prognostic risk factors, however initial combined treatment (HR 0.3, 95% CI 0.1-0.8, P = 0.019) predicted good prognosis in anti-MDA5 positive patients.Conclusion: Anti-MDA5 positive patients demonstrated a high prevalence of ILD on admission, leading to a high short-term mortality rate. Higher total GGO score, higher levels of initial KL-6 and CRP predict poor outcome in anti-MDA5 positive patients. However, initial intensive treatment may improve the prognosis.
Identification of plant leaf phosphorus content at different growth stages based on hyperspectral reflectance
Authors: Siedliska Anna , Baranowski Piotr , Pastuszka-Woźniak Joanna , Zubik Monika , Krzyszczak Jaromir
Published: December 2020

Background: Modern agriculture strives to sustainably manage fertilizer for both economic and environmental reasons. The monitoring of any nutritional (phosphorus, nitrogen, potassium) deficiency in growing plants is a challenge for precision farming technology. A study was carried out on three species of popular crops, celery (Apium graveolens L., cv. Neon), sugar beet (Beta vulgaris L., cv. Tapir) and strawberry (Fragaria × ananassa Duchesne, cv. Honeoye), fertilized with four different doses of phosphorus (P) to deliver data for non-invasive detection of P content. Results: Data obtained via biochemical analysis of the chlorophyll and carotenoid contents in plant material showed that the strongest effect of P availability for plants was in the diverse total chlorophyll content in sugar beet and celery compared to that in strawberry, in which P affects a variety of carotenoid contents in leaves. The measurements performed using hyperspectral imaging, obtained in several different stages of plant development, were applied in a supervised classification experiment. A machine learning algorithm (Backpropagation Neural Network, Random Forest, Naive Bayes and Support Vector Machine) was developed to classify plants from four variants of P fertilization. The lowest prediction accuracy was obtained for the earliest measured stage of plant development. Statistical analyses showed correlations between leaf biochemical constituents, phosphorus fertilization and the mass of the leaf/roots of the plants. Conclusions: Obtained results demonstrate that hyperspectral imaging combined with artificial intelligence methods has potential for non-invasive detection of non-homogenous phosphorus fertilization on crop levels.
KASP: a genotyping method to rapid identification of resistance in Plasmodium falciparum
Authors: Alvarez-Fernandez Ana , Bernal María J. , Villajos Isabel Fradejas , Ramírez Alexandra Martín , Yu Noor Azian Md , Suárez Marta Lanza , Hisam Shamilah , Perez-Ayala Ana , Rubio Jose M
Published: December 2020

BackgroundThe emergence and spread of antimalarial resistance continues to hinder malaria control. Plasmodium falciparum, the species that causes most human malaria cases and most deaths, has shown resistance to almost all known antimalarials. This antimalarial resistance arises from the development and subsequent expansion of Single Nucleotide Polymorfisms (SNPs) in specific parasite genes. A quick and cheap tool for the detection of drug resistance can be crucial and very useful for use in hospitals and in malaria control programs. It has been demonstrated in different contexts that genotyping by Kompetitive Allele Specific PCR (KASP), is a simple, fast and economical method that allows a high-precision biallelic characterization of SNPs, hence its possible utility in the study of resistance in P. falciparum.MethodsThree SNPs involved in most cases of resistance to the most widespread antimalarial treatments have been analyzed by PCR plus sequencing and by KASP (C580Y of the Kelch13 gene, Y86N of the Pfmdr1 gene and M133I of the Pfcytb gene). A total of 113 P. falciparum positive samples and 24 negative samples, previously analyzed by PCR and sequencing, were selected for this assay. Likewise, the samples were genotyped for the MSP-1 and MSP-2 genes, and the Multiplicity of Infection (MOI) and parasitaemia were measured to observe their possible influence on the KASP method.ResultsThe KASP results showed the same expected mutations and wild type genotypes as the reference method, with few exceptions that correlated with very low parasitaemia samples. In addition, two cases of heterozygotes that had not been detected by sequencing were found. No correlation was found between the MOI or parasitaemia and the KASP values of the sample. The reproducibility of the technique shows no oscillations between repetitions in any of the three SNPs analyzed.ConclusionsThe KASP assays developed in our study were efficient and versatile for the determination of the Plasmodium genotypes related to resistance. The method is simple, fast, reproducible with low cost in personnel, material and equipment and scalable, being able to core KASP arrays, including numerous SNPs, to complete the main pattern of mutations associated to P. falciparum resistance.
Personal Social Capital and Self-Rated Health among Middle-Aged and Older Adults: A Cross-sectional Study Exploring the Roles of Leisure-Time Physical Activity and Socioeconomic Status
Authors: Kim Youngdeok , Schneider Tim , Faß Eric , Lochbaum Marc
Published: December 2020

Background: Personal social capital, which refers to the scope and quality of an individual’s social networks within a community, has received increasing attention as a potential sociological factor associated with better individual health; yet, the mechanism relating social capital to health is still not fully understood. This study examined the associations between social capital and self-rated health while exploring the roles of leisure-time physical activity (LTPA) and socioeconomic status (SES) among middle-aged and older adults. Methods:Cross-sectional data were collected from 662 middle-aged and older adults (Mean age: 58.11±10.59 years old) using the Qualtrics survey panel. Personal Social Capital Scale was used to measure bonding and bridging social capital and the International Physical Activity Questionnaire was used to assess LTPA levels. SES was assessed by education and household income levels. Self-rated health was assessed using a single item, by which the participants were categorized into the two groups, having ‘good’ vs. ‘not good’ self-rated health. A series of univariate and multivariate logistic regression models were established to examine the independent and adjusted associations of social capital with self-rated health and to test mediating and moderating roles of LTPA and SES, respectively.Results:Bonding and bridging social capital were positively associated with self-rated health (Odds ratios = 1.11 and 1.09; P’s <.05, respectively), independent of LTPA that was also significantly associated with greater self-rated health (P-for-linear trends = .007). After adjusting SES, the associations of social capital were significantly attenuated and there was a significant interaction effect by household income (P-for-interaction = .012). Follow-up analyses stratified by household income showed that beneficial associations of social capital with self-rated health were more apparent among the people with low and high levels of household income; yet, LTPA was the stronger predictor of self-rated health among those in the middle class of household income. Conclusions:Findings suggest that both social capital and LTPA are associated with better self-rated health; yet, these associations vary by SES. The health policymakers should address both social capital and LTPA for enhancing perceived health among aging populations but may need to consider varying SES backgrounds.
Breastfeeding practice in China from 2013 to 2018: a study from a national dynamic follow-up surveillance
Authors: Kang Leni , Liang Juan , He Chunhua , Miao Lei , Li Xiaohong , Dai Li , Li Qi , Liu Zheng , Zhu Jun , Wang Yanping , Liu Hanmin
Published: December 2020

Background: Breastfeeding is important for the physical and psychological health of the mother and child. Basic data on breastfeeding practice in China are out-of-date and vary widely. This study aimed to evaluate the progress of breastfeeding practice in China, as well as to explore the bottlenecks in driving better practice.Methods: This was an observational study. We used data from the Under-5 Child Nutrition and Health Surveillance System in China for the period 2013-2018. The prevalence of early initiation of breastfeeding (EIBF) and exclusive breastfeeding (EBF) were calculated for each year for subgroups of China. The Cochran-Armitage test was used to explore the time trends. The annual percent of change (APC) were calculated by log-linear regression followed by exp transformation.Results: The prevalence of EIBF increased significantly from 44.57% (95% CI: 44.07, 45.07) in 2013 to 55.84% (95% CI: 55.29, 56.38) in 2018 (Ptrend<0.001), with an APC of 4.67% (95% CI: 3.51, 5.85). And the prevalence of EBF increased rapidly from 16.14% (95% CI: 15.10, 17.18) to 34.90% (95% CI: 33.54, 36.26) (Ptrend<0.001), with an APC of 14.90% (95% CI: 9.97, 20.04). Increases were observed in both urban and rural areas, with urban areas showing greater APCs for EIBF (6.05%; 95% CI: 4.22, 7.92 v.s. 2.26%; 95% CI: 1.40, 3.12) and EBF (18.21%; 95% CI: 11.53, 25.29 v.s. 9.43%; 95% CI: 5.52, 13.49). The highest EBF prevalence was observed in the East, but the Central area showed the highest APC. The prevalence of EBF decreased with increasing age within the first 6 months, especially after 3 months.Conclusion: The prevalence of both EIBF and EBF in China are improving in recent years. The rural and West China could be the key areas in the future actions. More efforts should be made to protect and promote breastfeeding to achieve near- and long-term goals for child health.
Characteristics of relief and residual low back pain after discectomy in patients with lumbar disc herniation: analysis using a detailed visual analogue scale
Authors: Takahashi Hiroshi , Aoki Yasuchika , Inoue Masahiro , Saito Junya , Nakajima Arata , Sonobe Masato , Akatsu Yorikazu , Koyama Keita , Shiga Yasuhiro , Inage Kazuhide , Eguchi Yawara , Orita Sumihisa , Maki Satoshi , Furuya Takeo , Akazawa Tsutomu , Abe Tetsuya , Funayama Toru , Noguchi Hiroshi , Miura Kousei , Mataki Kentaro , Shibao Yosuke , Eto Fumihiko , Kono Mamoru , Koda Masao , Yamazaki Masashi , Ohtori Seiji , Nakagawa Koichi
Published: December 2020

Background: Several authors have reported favorable results in low back pain (LBP) for patients with lumbar disc herniation (LDH) treated with discectomy. However, detailed changes over time in the characteristics and location of LBP before and after discectomy for LDH remain unclear. To clarify these points, we conducted an observational study to determine the detailed characteristics and location of LBP before and after discectomy for LDH, using a detailed visual analog scale (VAS) bilaterally.Methods: We included 65 patients with LDH treated by discectomy in this study. A detailed VAS for LBP was administered with the patient under 3 different conditions: in motion, standing, and sitting. Bilateral VAS was also administered (affected versus opposite side) for LBP, lower extremity pain (LEP), and lower extremity numbness (LEN). The Oswestry Disability Index (ODI) was used to quantify clinical status. Changes over time in these VAS and ODI were investigated. Pfirrmann grading and Modic change as seen by magnetic resonance imaging (MRI) were reviewed before and 1 year after discectomy to determine disc and endplate condition.Results: Before surgery, LBP on the affected side while the patients were in motion was significantly higher than LBP while they were sitting. This increased LBP on the affected side in motion was improved significantly after discectomy. By contrast, the residual LBP while sitting at 1 year after surgery was significantly higher than the LBP while they were in motion or standing. At 1 year following discectomy, residual LBP while sitting was significantly greater in cases showing changes in Pfirrmann grade or Modic type.Conclusions: Improvement of LBP on the affected side while the patient is in motion suggests that radicular LBP is improved following discectomy by nerve root decompression. Furthermore, that residual LBP is found while the patient is sitting is reflective of the load and pressure put on the disc and endplate.
Anastrozole and Levonorgrestrel-Releasing Intrauterine Device in the Treatment of Endometriosis: A Randomized Clinical Trial.
Authors: Acién Pedro , Velasco Irene , Acién Maribel
Published: December 2020

Background: To study the effectiveness of an aromatase inhibitor (Anastrozole) associated to levonorgestrel-releasing intrauterine device (LNG-IUD, Mirena®) in the treatment of endometriosis.Methods: Prospective, randomized clinical trial. Setting: University Hospital (single center). Elegibility criteria: Endometriomas >3×4 cm, CA-125>35 U/mL and endometriosis symptoms. Patients: Thirty-one women randomized to anastrozole+Mirena®+Conservative Surgery(CS) (n=8), anastrozole+Mirena®+transvaginal ultrasound-guided puncture-aspiration (TUGPA) (n=7), Mirena®+CS (n=9), or Mirena®+TUGPA (n=7). Interventions: Anastrozole 1 mg/day and/or only Mirena® for 6 months; CS (ovarian and fertility-sparing) or TUGPA of endometriomas one month after starting medical treatment. Main Outcome Measures: Visual analogic scale for symptoms, CA-125 levels, ultrasound findings of endometriomas and recurrences. Results: A significant improvement in symptoms during the treatment (difference of 43%, 95% CI 29.9-56.2) occurred, which was maintained at 1 and 2 years. It was more significant in patients treated with anastrozole (51%, 95% CI 33.3-68.7). For CA-125, the most significant decrease was observed without anastrozole (73.8%, 95% CI 64.2-83.4 vs. 53.8%, 95% CI 25.7-81.6 under Mirena®+anastrozole). After CS for endometriosis, a reduction of findings of endometriomas and long-term recurrences occurred, with or without anastrozole. At 4,2±1,7 years (95% CI 3,57-4,85), 88% of the patients who underwent CS were asymptomatic, without medication or reoperation, compared to only 21% if TUGPA was performed, with or without anastrozole (p=0.019). Conclusions: Dosing anastrozole for 6 months, starting one month before CS of endometriosis, reduces more significantly the painful symptoms and delays recurrences, but has no other significant advantages over the single insertion of LNG-IUD (Mirena®) during the same time. Anastrozole and/or only Mirena® associated with TUGPA are not effective.
The systemic review of subgroup analysis on the incidence of acute kidney injury(AKI) in patients with COVID-19
Authors: Xu Zhenjian , Tang Ying , Huang Qiuyan , Fu Sha , Li Xiaomei , Lin Baojuan , Xu Anping , Chen Junzhe
Published: December 2020

Background: Acute kidney injury (AKI) occurs among patients with Coronavirus disease-19 (COVID-19) and has also been proven to be associated with in-hospital mortality. Remdesivir has been authorized for the treatment of COVID-19 patients. We conducted a systematic review to evaluate the incidence of AKI in hospitalized COVID-19 patients. The incidence of AKI in different subgroups was also investigated. Method: A thorough search was carried out to find relevant studies in PubMed, Web of Science, medRxiv and EMBASE from 1 Jan 2020 until 1 June 2020. All systemic reviews of proportions were performed using the meta package for R project (4.0.1).Results: A total of 16199 COVID-19 patients were included in our systematic review. The pooled estimated incidence of AKI in all hospitalized COVID-19 patients was 10.0% (95% CI: 7.0-12.0%). The pooled estimated need for continuous renal replacement therapy (CRRT) in COVID-19 patients was 4% (95% CI: 3-6%). According to our subgroup analysis, the incidence of AKI could be associated with the age, disease severity and the ethnicity of the patients. The incidence of AKI in hospitalized COVID-19 patients being treated with remdesivir was 7% (95% CI: 3-13%) in a total of 5 studies.Conclusion: We found that AKI was not rare in hospitalized COVID-19 patients. The incidence of AKI could be associated with age, disease severity and ethnicity. Remdesivir probably not induced AKI in COVID-19 patients. Our systemic review provides evidence for future studies that AKI might be closely associated with SARS-CoV-2 infection.
Community stakeholder preferences for evidence-based practice implementation strategies in behavioral health: A best-worst scaling choice experiment
Authors: Williams Nathaniel , Candon Molly , Stewart Rebecca , Byeon Y. Vivian , Bewtra Meenakshi , Buttenheim Alison , Zentgraf Kelly , Comeau Carrie , Shoyinka Sosunmolu , Beidas Rinad S.
Published: December 2020

Background: Community behavioral health clinicians, supervisors, and administrators play an essential role in implementing new psychosocial evidence-based practices (EBP) for patients receiving psychiatric care; however, little is known about these stakeholders’ values and preferences for implementation strategies that support EBP use, nor how best to elicit, quantify, or segment their preferences. This study sought to quantify these stakeholders’ preferences for implementation strategies and to identify segments of stakeholders with distinct preferences using a rigorous choice experiment method called best-worst scaling. Methods: A total of 240 clinicians, 74 clinical supervisors, and 29 administrators employed within clinics delivering publicly-funded behavioral health services in a large metropolitan behavioral health system participated in a best-worst scaling choice experiment. Participants evaluated 14 implementation strategies developed through extensive elicitation and pilot work within the target system. Preference weights were generated for each strategy using hierarchical Bayesian estimation. Latent class analysis identified segments of stakeholders with unique preference profiles. Results: On average, stakeholders preferred two strategies significantly more than all others—compensation for use of EBP per session and compensation for preparation time to use the EBP (P<.05); two strategies were preferred significantly less than all others—performance feedback via email and performance feedback via leaderboard (P<.05). However, latent class analysis identified four distinct segments of stakeholders with unique preferences: Segment 1 (n = 121, 35%) strongly preferred financial incentives over all other approaches and included more administrators; Segment 2 (n = 80, 23%) preferred technology-based strategies and was younger, on average; Segment 3 (n = 52, 15%) preferred an improved waiting room to enhance client readiness, strongly disliked any type of clinical consultation, and had the lowest participation in local EBP training initiatives; Segment 4 (n = 90, 26%) strongly preferred clinical consultation strategies and included more clinicians in substance use clinics. Conclusions: The presence of four heterogeneous subpopulations within this large group of clinicians, supervisors, and administrators suggests optimal implementation may be achieved through targeted strategies derived via elicitation of stakeholder preferences. Best-worst scaling is a feasible and rigorous method for eliciting stakeholders’ implementation preferences and identifying subpopulations with unique preferences in behavioral health settings.
Knowledge, Attitude, And Perception of Oral and Maxillofacial Surgery Specialty Amongst Healthcare Professionals, and the General Public from a Gulf Cooperation Council (GCC) Country
Authors: Kamal Mohammad , Abdulwahab Mohammad , Al-Zaid Ahmed
Published: December 2020

Background: Oral and maxillofacial surgery specialty has grown rapidly in Kuwait in recent years. However, the general public and healthcare professionals remain unaware of its expanding scope of practice. The aim of the study is to assess public and professional (dental and medical) perception of the oral and maxillofacial surgical specialty in Kuwait.Methods: This is a cross-sectional study evaluating responses of dental professionals, medical professionals, and general public in Kuwait toward the oral and maxillofacial surgical specialty using a previously validated survey instrument with 100 participants in each group. Participants were asked to choose the most appropriate specialist to treat certain procedures across 4 disciplines: reconstruction, trauma, pathology, and cosmetic. Statistical comparison was conducted between dentists and medical doctors using Fisher’s exact test with a p-value of < 0.05. Results: Disparities were noted each group’s responses. Oral and maxillofacial surgery was preferred overall for most clinical scenarios in trauma (p < 0.001), pathology (p < 0.001), and reconstructive surgery (p < 0.001). Plastic surgery was preferred for cosmetic surgeries (p < 0.001). Conclusions: This study indicates the need to increase awareness especially towards cosmetic surgery procedures, and conduct health campaigns regarding oral and maxillofacial surgery among healthcare professionals, especially medical doctors, and the general public.
Epidemiological profile of Plasmodium ovale spp. imported from Africa to Anhui Province, China, 2012 – 2019
Authors: Zhang Tao , Wang Shuqi , Wang Duoquan , Auburn Sarah , Lu Shenning , Xu Xian , Jiang Jingjing , Lyu Xiaofeng , Yu Chen , Tian Cuicui , Li Shizhu , Li Weidong
Published: December 2020

BackgroundAlthough autochthonous malaria cases are no longer reported in Anhui Province, China, imported malaria has become a major health concern. The proportion of reported malaria cases caused by Plasmodium ovale spp. increased to levels higher than expected during 2012 to 2019, and showed two peaks, 19.69 % in 2015 and 19.35 % in 2018.MethodsA case-based retrospective study was performed using data collected from the China Information System for Disease Control and Prevention (CISDCP) and Information System for Parasitic Disease Control and Prevention (ISPDCP) from 2012 to 2019 to assess the trends and differences between Plasmodium ovale curtisi (P. o. curtisi) and Plasmodium ovale wallikeri (P. o. wallikeri). Epidemiological characteristics were analyzed using descriptive statistics.ResultsP. ovale curtisi and P. ovale wallikeri were found to simultaneously circulate in 14 African countries. Among 128 patients infected with P. ovale spp., the proportion of co-infection cases was 10.16%. Six cases of co-infection with P. ovale spp. and P. falciparum were noted, each presenting with two clinical attacks (the first attack was due to P. falciparum and the second was due to P. ovale spp.) at different intervals. Accurate identification of the infecting species was achieved among only 20.00% of cases of P. ovale spp. infection. At the reporting units, 32.17% and 6.96% of cases of P. ovale spp. infection were misdiagnosed as P. vivax and P. falciparum infections, respectively. ConclusionThe present results indicate that the potential of P. ovale spp. to co-infect with other Plasmodium species has been previously underestimated, as is the incidence of P. ovale spp. in countries where malaria is endemic. P. o. curtisi may have a long latency period of >3 years and potentially cause residual foci, thus posing challenges to the elimination of malaria in P. ovale spp.-endemic areas. Considering the low rate of species identification, more sensitive point-of-care detection methods need to be developed for P. ovale spp. and introduced in non-endemic areas.
Association of depression symptom severity with short-term risk of an initial hospital encounter in adults with major depressive disorder
Authors: Voelker Jennifer , Wang Kun , Tang Wenze , He Jinghua , Daly Ella , Pericone Christopher D , Sheehan John J
Published: December 2020

Background: Despite the availability of pharmacologic and nonpharmacologic treatment options, depression continues to be one of the leading causes of disability worldwide. This study evaluated whether depression symptom severity, as measured by PHQ-9 score, of patients diagnosed with MDD is associated with short-term risk of a hospital encounter (ER visit or inpatient stay). Methods: Adults with ≥1 PHQ-9 assessment in an outpatient setting (index date) and ≥1 MDD diagnosis within 6 months prior were included from the de-identified Optum Electronic Health Record database (April 2016-June 2019). Patients were categorized by depression symptom severity based on PHQ-9 scores obtained by natural language processing. Crude rates, adjusted absolute risks, and adjusted relative risks of all-cause and MDD-related hospital encounters within 30 days following assessment of depression severity were determined.Results: The study population consisted of 280 145 patients with MDD and ≥1 PHQ-9 assessment in an outpatient setting. Based on PHQ-9 scores, 26.9% of patients were categorized as having none/minimal depression symptom severity, 16.4% as mild, 24.7% as moderate, 19.6% as moderately severe, and 12.5% as severe. Among patients with none/minimal, mild, moderate, moderately severe, and severe depression, the adjusted absolute short-term risks of an initial all-cause hospital encounter were 4.1%, 4.4%, 4.8%, 5.6%, and 6.5%, respectively; MDD-related hospital encounter adjusted absolute risks were 0.8%, 1.0%, 1.3%, 1.6%, and 2.1%, respectively. Compared to patients with none/minimal depression symptom severity, the adjusted relative risks of an all-cause hospital encounter were 1.60 (95% CI 1.50-1.70) for those with severe, 1.36 (1.29-1.44) for those with moderately severe, 1.18 (1.12-1.25) for those with moderate, and 1.07 (1.00-1.13) for those with mild depression symptom severity. Conclusions: These study findings indicate that depression symptom severity is a key driver of short-term risk of hospital encounters, emphasizing the need for timely interventions that can ameliorate depression symptom severity.
Three-dimensional analysis of the root canal preparation with Reciproc Blue®, WaveOne Gold® and XP EndoShaper®. A new method in vivo
Authors: Caviedes-Bucheli Javier , Rios-Osorio Nestor , Usme Diana , Jimenez Cristian , Pinzon Adriana , Rincón Jorge , Azuero-Holguin María M , Zubizarreta-Macho Alvaro , Gomez-Sosa Jose F , Munoz Hugo R
Published: December 2020

Background: The purpose of this study was to evaluate the changes in canal volume after root canal preparation in vivo with 3 different single-file techniques (Reciproc-Blue®, WaveOne-Gold® and XP-EndoShaper®), with a new method using CBCT and 3D reconstruction. Methods: In this prospective study, thirty human lower premolars from healthy patients were used, in which extraction was indicated for orthodontic reasons. All the teeth used were caries- and restoration-free with complete root development, without signs of periodontal disease or traumatic occlusion, and with only one straight canal (up to 25º curvature). Teeth were randomly divided into three different groups: Reciproc-Blue, WaveOne-Gold and XP-EndoShaper. CBCT scans before root canal preparation were used to create a 3D reconstruction with RHINOCEROS 5.0 software to assess the initial canal volume, and then compared with 3D reconstructions after canal preparation to measure the increase in canal volume. Student’s t test for paired data were used to determine statistically significant differences between the before and after canal volumes. Anova test was used to determine statistically significant differences in the percentage of canal volume increase between the groups and Tukey's post-hoc test were used to paired comparison.Results: Reciproc-Blue showed the higher increase in canal volume, followed by WaveOne-Gold and XP-EndoShaper (p = 0.003). XP-EndoShaper did not show a statistically significant increase in canal volume after root canal preparation (p = 0.06).Conclusion: With this model, Reciproc-Blue showed higher increase in root canal volume, followed by WaveOne-Gold, while XP-EndoShaper did not significantly increase root canal volume during preparation.
A NOVEL METHOD FOR THE M-TERMS OF SHIP WITH FORWARD SPEED
Authors:   College of Shipbuilding Engineering, Harbin Engineering University，Harbin,  Heilongjiang 150001, China., Chen J.K. , Duan W.Y.
Published: December 2020

One of the major difficulties in linear wave-induced ship motion problem with forward speed is how to solve the m-terms accurately. This paper proposes a novel numerical method (Taylor Expansion Boundary Element Method, TEBEM) to compute the m-terms for arbitrary floating bodies. This method treats the m-terms as the Dirichlet type, uses the first-order derivatives terms on the right-handed side of boundary value problem, which is solved by TEBEM method. Numerical studies are performed for the hemisphere, mounted cylinder, and modified KVLCC2 ship models. Compared to the analytical solutions and other numerical results, a good agreement can be obtained by the TEBEM method.
Photocatalytic Activity of CdS Nanoparticles Obtained by Microbial Synthesis on the Model of Decolorization of Methylene Blue Dye
Authors: Zhuravliova O.A. , Voeikova T.A. , Debabov V.G.
Published: December 2020

It has been demonstrated for the first time that biogenic nanoparticles of cadmium sulfide (NPsCdS) obtained using the bacterial strain Bacillus subtilis 168 by an optimized environmentally friendly, nature-like microbial synthesis are able to photocatalytically decolorize methylene blue dye under UV irradiation (365 nm). NPsCdS, characterized as quantum dots, fluoresce in the blue spectral region (400-440 nm), have a spherical shape, a diameter of 5±1 nm and a hydrodynamic diameter of 250--300 nm. The dynamics of methylene blue decolorization was studied depending on the NPsCdS and the dye concentrations, the thickness of the dye solution layer, as well as the power and time of exposure to UV irradiation. The possibility of reusing biogenic NPsCdS for dye decolorization was shown, which characterizes the photostability of the nanoparticles and is relevant for the practical application of biogenic photonanocatalysts. biogenic CdS nanoparticles, Bacillus subtilis 168, photocatalysis, UV irradiation, methylene blue The authors are grateful to the Russian National Collection of Industrial Microorganisms of NRC "Kurchatov Institute" - GOSNIIGENETIKA for providing the bacterial strains and to the Kurchatov Genomic Center-NRC "Kurchatov Institute"- GosNIIGENETIKA for the opportunity to determine the photocatalytic degradation of the dye using biogenic nanoparticles on spectrophotometric equipment. This work was supported by the Russian Foundation for Basic Research in the framework of project no. 19-04-00088.
AKTİF YAŞLANMA BAĞLAMINDA YAŞ DOSTU KENT KAVRAMI
Authors: TAMKOÇ Betül , BİLGİN Ömer Faruk
Published: December 2020

Endüstrileşme, kentleşme, bilimde ve teknolojide kaydedilen ilerlemeler gibi etkenler sonucunda doğum oranları azalmakta ve doğuşta beklenen yaşam süresi artmaktadır. Bunun doğal bir sonucu olarak dünya nüfusu giderek artan bir hızla yaşlanmakta ve toplam nüfus içerisinde yaşlı nüfus oranı artmaktadır. Demografik yapıda yaşanan bu değişimler artan ömrün insan onuruna yaraşır bir şekilde yaşanması için küresel ölçekte çözümler üretilmesini ve politikalar geliştirilmesini gerektirmektedir. Bu durum ulusal ve uluslararası ölçekte birçok kuruluşu harekete geçirmiştir. Bu kapsamda yapılan toplantılarda yaşlanma olgusu çok boyutlu olarak ele alınmış olup yaşlı bireylerin refahını geliştirmeye yönelik çeşitli kararlar alınmıştır. Bu bağlamda Dünya Sağlık Örgütü (DSÖ) tarafından 2002 yılında gelişmekte olan ülkeleri desteklemek ve yaşlanan dünyada sağlık ve sosyal alandaki politikaları güçlendirmek için Aktif Yaşlanma Politika Çerçevesi yayınlanmıştır. Ancak toplumdaki tüm bireylerin topluma etkin ve tam katılımının fiziksel ve sosyal çevrede bir düzenleme yapılmadan mümkün olamayacağından hareketle aktif ve sağlıklı yaşlanmayı amaçlayan Yaş Dostu Kentler (Age Friendly Cities) Projesi hayata geçirilmiştir. Bu çalışmada yaş dostu kentlerin aktif yaşlanma bağlamında değerlendirilmesi amaçlanmaktadır. Bu kapsamda öncelikle yaşlanan nüfus ve kentleşme konuları ele alınmıştır. Daha sonra yaş dostu kent kavramı açıklanmış olup dünyada ve Türkiye’de yaş dostu kent uygulamaları aktif yaşlanma bağlamında değerlendirilmiş ve çıkarımlarda bulunulmuştur.
FENOMENA DAKWAH EKS-HTI PASCA DIBUBARKAN
Authors: Fitriyana Siti Nur
Published: December 2020

This paper talking about phenomenon of ex-HTI as forbidden mass organization that is khilafah ideologically. Its existence in Indonesia is still developed through all media, print media and new media. Print media (bulletin) that shaded by ex-HTI is subscribed by the community. This is proven by the total production of print media (bulletin) to reach 10.000 eksemplar for distributed in Indonesia and then which is no less important is use of new media to show dakwah of ex-HTI related to khilafah still working massively. This could be proven by many posts on each social media account, that is to reach 849 posts. Both media discuss about the khilafah. The results of this research shows that all media shaded by ex-HTI changes the movement name become GP (Gerakan Pembebasan), BMI (Back To Muslim Identity), and Muslimah News Id. Technique data collection uses documentation and interview. This research concludes that dakwah activities of ex-HTI about khilafah are massive and structured. This is seen from social media account managed by ex-HTI that is  still posting the content of khilafah which are expeted to be enforced. 

 
Etika komunikasi Islam mahasiswa organisasi PMII (Pergerakan Mahasiswa Islam Indonesia) dalam menangkal berita hoaks di Facebook
Authors: Wafda Ila Khafia
Published: December 2020

This study aims to see how Islamic communication ethics is in an effort to ward off hoax news on Facebook that hit students of the PMII. The reason is, the existence of hoax reporting on Facebook contradicts the vision of the PMII organization which is committed to being a forum for strengthening aqidah, morals, and creating a society like the Ummah. The research used qualitative research methods through in-depth interview approaches and observations of active students in the PMII organization uses a sampling technique based on purposive sampling technique. The results showed that students instilled communication ethics according to Islamic law in using Facebook social media, so steps need to be taken to communicate in accordance with Islamic teachings to avoid the rampant hoax news on Facebook to promote morals according to Islamic law refer to the example of the Prophet, p.b.u.h. That it is important for PMII student organizations to promote morals in accordance with Islamic law, and also apply communication ethics in accordance with Islamic law by promoting the principles of Islamic communication, namely: qawlan sadidan, qawlan balighan, qawlan maysura, qawlan layyina, qawlan karima, qawlan ma'rufa. So it is necessary to understand and apply Islamic communication ethics by students of the PMII organization so that it becomes the basis for accessing Facebook.
Belanja on-line mahasiswa di era pandemi covid-19: modifikasi perilaku konsumen
Authors: Utari Prahastiwi , Fitri Annisaa , Setyanto Eko , Henny Chatarina
Published: December 2020

The Covid-19 pandemic has changed students consumer behavior from offline to online. The problem in this research is how students’ consumer behavior in online shopping in the era of the Covid-19 pandemic, and the modification of consumer behavior due to regulations and procedures for shopping and buying the products they need. This research is a quantitative study using a survey method. This study is a quantitative research using a survey method. Sampling was done by stratified random sampling, the number of those students FISIP UNS involved as many as 80 people. The results and conclusions of research show that in online shopping, there is a modification of consumer behavior related student needs product, information search, evaluation prior to purchase or an alternative choice, and in the decision to buy or use the product.
Narrativas do esgotamento e a historiografia (literária) brasileira no Antropoceno
Authors: Simoni Mariana
Published: December 2020

Tomando como ponto de partida a entronização do conceito de Antropoceno nos discursos das Ciências Humanas, o artigo vincula o novo impulso narrativo gerado pela consciência tanto do impacto destrutivo da ação humana sobre o planeta Terra quanto pela ameaça de esgotamento dos recursos naturais – em última instância, diretamente vinculada à extinção da própria espécie humana – à emergência de narrativas do esgotamento comprometidas com práticas situadas de resistência. O objetivo é enfatizar o aspecto performativo neste novo gesto de narrar, que invariavelmente implica reescrituras da história literária brasileira a partir de perspectivas mais além do humano. Do ponto de vista metodológico, o artigo apoia-se no diálogo entre teorias neomaterialistas (HARAWAY, 1988; 2015; 2016) e do perspectivismo ameríndio (VIVEIROS DE CASTRO, 2009; 2014) com constructos teóricos propostos pela École des Annales revisitados por historiadores contemporâneos (CHAKRABARTY, 2009; SAWYER, 2015).
PERTURBAÇÕES NO CAMPO GEOMAGNÉTICO CAUSADAS PELO TERREMOTO E PELO TSUNAMI DE MAULE, CHILE (2010)
Authors: Klausner Virginia , Cezarini Marina Vedelago , Santos Thiago de Almeida
Published: December 2020

Este estudo foca na análise das perturbações do campo geomagnético que estão relacionadas com o terremoto, e consequente tsunami, que ocorreram em 27 de fevereiro de 2010 em Maule, no Chile. O objetivo deste artigo é contribuir para uma melhor compreensão dos processos físicos envolvidos nos acoplamentos Tsunami-Atmosfera-Ionosfera (TAI) e Litosfera-Atmosfera-Ionosfera (LAI). Para isto, foram utilizados registros de magnetômetros fluxgate medidos em superfície fornecidos pelo projeto LISN (do inglês Low Latitude Ionospheric Sensor Network). A metodologia de filtragem do sinal por remoção da tendência relacionada à influência solar (linha de base Sq, do inglês Solar quiet) considerando os cinco dias geomagneticamente mais calmos foi aplicada. Os resultados mostraram distúrbios geomagnéticos, em ambas componentes H e Z, nos dados filtrados que ocorreram quase instantaneamente ou com atraso de até 100 minutos após a chegada do tsunami. Estes distúrbios são atribuídos aos mecanismos oceânico e ionosférico. Estudos como esse são importantes para uma futura condição de previsão e alerta de desastres dessa natureza.
Expert, intelectual e/ou polímata? Uma contribuição para a História da Educação Matemática
Authors: Silva Neto Oscar , COSTA David Antonio da
Published: December 2020

O presente trabalho foi realizado com apoio da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (Capes) - Código de Financiamento 001 e surgiu do desdobramento de uma pesquisa de doutorado em andamento que tem o objetivo de problematizar os conceitos de expert, intelectual e polímata, no intuito de auxiliar as pesquisas no âmbito da História da Educação Matemática. Foram utilizados referenciais teórico-metodológicos como Hofstetter e Schneuwly (2017), para definir experts; Vieira (2011), para definir intelectuais; e Burke (2011; 2016) para definir polímatas. Os estudos mostram que cada vocábulo possui uma definição própria, com características que lhes são peculiares e que não são tratados como sinônimos, tampouco como antônimos. Eles simplesmente possuem funções diferentes e o que importa, na realidade, é perceber o conhecimento que produzem.
Technique and Methodology for Objective Evaluation of Borrowings in Academic Texts
Authors: Avdeeva N. V. , Ivanova E. N.
Published: December 2020

Purpose. To provide a detailed justification of the methodological principles, guided by the specialists of the “Antiplagiat.RSL” project when conducting an independent assessment of the originality of scientific texts.

Materials and methods. The implementation of these principles is demonstrated with the examples from the practice of tests. The proposed material based on more than ten years of experience of plagiarism – test practice, will give authors and administrators of scientific institutions a clearer idea of the procedure and requirements for academic texts.

Results. The automated verification of academic texts for plagiarism has become commonplace, which affects all levels - from writing graduate qualification papers to defending doctoral dissertations, publishing monographs and textbooks. There is a wide range of software specially designed for comparing texts and identifying both distinct overlapping text fragments and paraphrased ones. At the same time, everyone who has come across the verification process understands that it is impossible to rely solely on the quantitative indicators presented in the system report. Evaluation of plagiarism-test results is an area where one has to deal with different, sometimes not entirely correct, understanding of the originality of scientific texts.

The Russian State Library (RSL) is a national repository and, what is even more important - it remains independent from the academic institutional milieu. The article describes essential principles of the plagiarism tests, carried out at the RSL, which are based on the organizational legitimacy, identification of individual motivation and compliance with the actual normative regulation. Methodology of the tests founds on the five key principles: objectivity, confidentiality, consistency, specificity and complexity.

In addition, certain issues of an objective evaluation of plagiarism are considered in order to draw attention to the fact that independent (delegated) verification of scientific texts is one of the components of the process of supporting academic integrity in modern conditions of dissemination and reproduction of information.

Conclusion. A detailed check of the texts for plagiarism allows you to make corrections, modify the texts, and eliminate shortcomings caused by the author’s carelessness or negligence. At the same time, deliberate plagiarism even if it may seem insignificant, is the most serious misconduct from the point of view of scientific ethics, and institutional control in this area is necessary.
Business Process Modeling During Bachelors Training in “Business Informatics” in the Con-text of Digital Transformation of Enterprises
Authors: Ushakova M. V. , Gabalin A. V.
Published: December 2020

Purpose of the study. The aim of the study is to analyze the effectiveness of the joint use of the competence-activity approach and interdisciplinary connections in the formation of model-ing skills in the field of enterprise engineering and reengineering of business processes in the edu-cational process of the university. The relevance of the problems outlined in this article is determined by the need to develop human resources in the IT industry and to continuously improve the quality of training specialists in this area.

The object of the research is the preparation of full-time students of educational institu-tions of higher education in terms of the formation of skills in systemic and business analysis of a digital enterprise as an object of economics and management.

Materials and research methods. The article analyzes the possibility of effective use of the competence-activity approach and interdisciplinary connections in the educational process when developing modeling skills as part of the research work of bachelors in the direction of “Business Informatics”.

Results. Taking into account the analysis of the experience of using the competence-activity approach and interdisciplinary relations, there are shown the prospects of their joint use in the educational process in the formation of modeling skills in the field of enterprise engineering and reengineering of business processes. The structure of the research work of students and the sequence of stages of modeling are proposed, which have proven themselves well at the Business Informatics Chair and Production Management Systems.

Conclusion. In the transition to the digital economy, the key difficulty in our country is the lack of qualified and competent personnel. It is necessary to correctly form the approaches to the training of IT industry specialists. The joint use of the competenceactivity approach at the Na-tional University of Science and

Technology “MISIS”, which implies the formation of knowledge among students in the process of developing a process information system project and interdisci-plinary relations, has confirmed its effectiveness. The experience of using business process mod-eling in the preparation of bachelors, training with specialty “Business Informatics” is generalized and a sequence of modeling steps is proposed, which allows to consider and comprehensively de-scribe a digital enterprise as an object of economics and management in the form of architectural models, as well as an approach to the formation of skills in modeling and business management processes of the enterprise for students.

This approach made it possible to involve students in the process of active learning, im-prove the process of forming key competencies, significantly improve the quality of theses and their practical significance, as well as increase the level of teaching compliance with world trends in the era of digital transformation.