bluuebunny/crossref_metadata_2025 huggingface dataset:
The Mechanical Properties of Fiber Metal Laminates Based on 3D Printed Composites
Authors: Yelamanchi Bharat , MacDonald Eric , Gonzalez-Canche Nancy G. , Carrillo Jose G. , Cortes Pedro
Published: November 2020

The production and mechanical properties of fiber metal laminates (FMLs) based on 3D printed composites have been investigated in this study. FMLs are structures constituting an alternating arrangement of metal and composite materials that are used in the aerospace sector due to their unique mechanical performance. 3D printing technology in FMLs could allow the production of structures with customized configuration and performance. A series of continuous carbon fiber reinforced composites were printed on a Markforged system and placed between layers of aluminum alloy to manufacture a novel breed of FMLs in this study. These laminates were subjected to tensile, low velocity and high velocity impact tests. The results show that the tensile strength of the FMLs falls between the strength of their constituent materials, while the low and high velocity impact performance of the FMLs is superior to those observed for the plain aluminum and the composite material. This mechanism is related to the energy absorption process displayed by the plastic deformation, and interfacial delamination within the laminates. The present work expects to provide an initial research platform for considering 3D printing in the manufacturing process of hybrid laminates.
Phase Transition Kinetics in Austempered Ductile Iron (ADI) with Regard to Mo Content
Authors: Landesberger Martin , Koos Robert , Hofmann Michael , Li Xiaohu , Boll Torben , Petry Winfried , Volk Wolfram
Published: November 2020

The phase transformation to ausferrite during austempered ductile iron (ADI) heat treatment can be significantly influenced by the alloying element Mo. Utilizing neutron diffraction, the phase transformation from austenite to ausferrite was monitored in-situ during the heat treatment. In addition to the phase volume fractions, the carbon enrichment of retained austenite was investigated. The results from neutron diffraction were compared to the macroscopic length change from dilatometer measurements. They show that the dilatometer data are only of limited use for the investigation of ausferrite formation. However, they allow deriving the time of maximum carbon accumulation in the retained austenite. In addition, the transformation of austenite during ausferritization was investigated using metallographic methods. Finally, the distribution of the alloying elements in the vicinity of the austenite/ferrite interface zone was shown by atom probe tomography (APT) measurements. C and Mn were enriched within the interface, while Si concentration was reduced. The Mo concentration in ferrite, interface and austentite stayed at the same level. The delay of austenite decay during Stage II reaction caused by Mo was studied in detail at 400 °C for the initial material as well as for 0.25 mass % and 0.50 mass % Mo additions.
Influence of Chemical Pre-Treatments and Ultrasonication on the Dimensions and Appearance of Cellulose Fibers
Authors: Mazela Bartłomiej , Perdoch Waldemar , Peplińska Barbara , Zieliński Mikołaj
Published: November 2020

Due to the wider use of nanocellulose in various areas of economic life, better and more optimal methods of obtaining nanocellulose are constantly being sought. Therefore, an attempt was made to evaluate the hybrid cellulose treatment, based on the use of a chemical method combined with an ultrasound of medium frequency. The study employs two different starting materials (Södra Black R cellulose or microcrystalline cellulose), two types of chemical pre-treatments (acid hydrolysis or oxidation), and two sonication durations. It was found that the reduction fiber cross-sectional dimensions was the result of prolonged exposure of cellulose to the ultrasound. From Södra Black R and the microcrystalline cellulose nanometer scale, structures were obtained in the form of isolated fibers. The TEMPO reagent accelerated the degradation process of two cellulose varieties due to its oxidizing character. The resulting products had nanofibrous structures. Cellulose degradation as a result of the combined action of sonication and TEMPO activity progressed gradually. Places of fiber degradation were characterized by their longitudinal breakage and initiated the next stages of the defibering process.
Challenges in a Hybrid Fabrication Process to Generate Metallic Polarization Elements with Sub-Wavelength Dimensions
Authors: Belle Stefan , Goetzendorfer Babette , Hellmann Ralf
Published: November 2020

We report on the challenges in a hybrid sub-micrometer fabrication process while using three dimensional femtosecond direct laser writing and electroplating. With this hybrid subtractive and additive fabrication process, it is possible to generate metallic polarization elements with sub-wavelength dimensions of less than 400 nm in the cladding area. We show approaches for improving the adhesion of freestanding photoresist pillars as well as of the metallic cladding area, and we also demonstrate the avoidance of an inhibition layer and sticking of the freestanding pillars. Three-dimensional direct laser writing in a positive tone photoresist is used as a subtractive process to fabricate free-standing non-metallic photoresist pillars with an area of about 850 nm × 1400 nm, a height of 3000 nm, and a distance between the pillars of less than 400 nm. In a subsequent additive fabrication process, these channels are filled with gold by electrochemical deposition up to a final height of 2200 nm. Finally, the polarization elements are characterized by measuring the degree of polarization in order to show their behavior as quarter- and half-wave plates.
Improving the Mechanical Response of Al–Mg–Si 6082 Structural Alloys during High-Temperature Exposure through Dispersoid Strengthening
Authors: Rakhmonov Jovid , Liu Kun , Rometsch Paul , Parson Nick , Chen X.-Grant
Published: November 2020

The feasibility and efficacy of improving the mechanical response of Al–Mg–Si 6082 structural alloys during high temperature exposure through the incorporation of a high number of α-dispersoids in the aluminum matrix were investigated. The mechanical response of the alloys was characterized based on the instantaneous high-temperature and residual room-temperature strengths during and after isothermal exposure at various temperatures and durations. When exposed to 200 °C, the yield strength (YS) of the alloys was largely governed by β” precipitates. At 300 °C, β” transformed into coarse β’, thereby leading to the degradation of the instantaneous and residual YSs of the alloys. The strength improvement by the fine and dense dispersoids became evident owing to their complementary strengthening effect. At higher exposure temperatures (350–450 °C), the further improvement of the mechanical response became much more pronounced for the alloy containing fine and dense dispersoids. Its instantaneous YS was improved by 150–180% relative to the base alloy free of dispersoids, and the residual YS was raised by 140% after being exposed to 400–450 °C for 2 h. The results demonstrate that introducing thermally stable dispersoids is a cost-effective and promising approach for improving the mechanical response of aluminum structures during high temperature exposure.
Facile Synthesis of g-C3N4/TiO2/Hectorite Z-Scheme Composite and Its Visible Photocatalytic Degradation of Rhodamine B
Authors: You Rong , Chen Jinyang , Hong Menghan , Li Jinrui , Hong Xiaomin
Published: November 2020

A novel g-C3N4/TiO2/hectorite Z-scheme composites with oxygen vacancy (Vo) defects and Ti3+ were synthesized by so-gel method and high temperature solid phase reaction. This composite exhibited high visible photo-catalytic degradation of rhodamine B (RhB). The apparent rate constant of g-C3N4/TiO2/hectorite was 0.01705 min−1, which is approximately 5.38 and 4.88 times that of P25 and g-C3N4, respectively. The enhancement of photo-catalytic efficiency of the composites can be attributed to the great light harvesting ability, high specific surface area and effective separation of electrons(e−) and holes(h+). The F element from Hectorite causes the formation of Vo and Ti3+ in TiO2, making it responsive to visible light. The effective separation of e− and h+ mainly results from Z-scheme transfer of photo-produced electrons in g-C3N4/TiO2 interface. The composites can be easily recycled and the degradation rate of the RhB still reached 84% after five cycles, indicating its good reusability.
Mechanical and Tribological Behavior of Mechanically Alloyed Ni-TiC Composites Processed via Spark Plasma Sintering
Authors: Walunj Ganesh , Bearden Anthony , Patil Amit , Larimian Taban , Christudasjustus Jijo , Gupta Rajeev Kumar , Borkar Tushar
Published: November 2020

Titanium carbide (TiC) reinforced nickel (Ni) matrix composites were processed via mechanical alloying (MA) followed by spark plasma sintering (SPS) process. Mechanical alloying has gained special attention as a powerful non-equilibrium process for fabricating amorphous and nanocrystalline materials, whereas spark plasma sintering (SPS) is a unique technique for processing dense and near net shape bulk alloys with homogenous microstructure. TiC reinforcement varied from 5 to 50 wt.% into nickel matrix to investigate its effect on the microstructure and mechanical behavior of Ni-TiC composites. All Ni-TiC composites powder was mechanically alloyed using planetary high energy ball mill with 400 rpm and ball to powder ratio (BPR) 15:1 for 24 h. Bulk Ni-TiC composites were then sintered via SPS process at 50 MPa pressure and 900–1200 °C temperature. All Ni-TiC composites exhibited higher microhardness and compressive strength than pure nickel due to the presence of homogeneously distributed TiC particles within the nickel matrix, matrix grain refinement, and excellent interfacial bonding between nickel and TiC reinforcement. There is an increase in Ni-TiC composites microhardness with an increase in TiC reinforcement from 5 to 50 wt.%, and it reaches the maximum value of 900 HV for Ni-50TiC composites.
Monolayer Graphene Transfer onto Hydrophilic Substrates: A New Protocol Using Electrostatic Charging
Authors: Kafiah Feras , Laoui Tahar , Abdelsalam Emad , Atieh Muataz , Khan Zafarullah , Alkasrawi Malek
Published: November 2020

In the present work, we developed a novel method for transferring monolayer graphene onto four different commercial hydrophilic micro/ultra-filtration substrates. The developed method used electrostatic charging to maintain the contact between the graphene and the target substrate intact during the etching step through the wet transfer process. Several measurement/analysis techniques were used in order to evaluate the properties of the surfaces and to assess the quality of the transferred graphene. The techniques included water contact angle (CA), atomic force microscopy (AFM), and field emission scanning electron microscopy (FESEM). Potassium chloride (KCl) ions were used for the transport study through the developed graphene-based membranes. The results revealed that 70% rejection of KCI ions was recorded for the graphene/polyvinylidene difluoride (PVDF1) membrane, followed by 67% rejection for the graphene/polyethersulfone (PES) membrane, and 65% rejection for graphene/PVDF3 membrane. It was revealed that the smoothest substrate was the most effective in rejecting the ions. Although defects such as tears and cracks within the graphene layer were still evolving in this new transfer method, however, the use of Nylon 6,6 interfacial polymerization allowed sealing the tears and cracks within the graphene monolayer. This enhanced the KCl ions rejection of up to 85% through the defect-sealed graphene/polymer composite membranes.
Curvature-Dependent Electrostatic Field as a Principle for Modelling Membrane-Based MEMS Devices. A Review
Authors: Versaci Mario , di Barba Paolo , Morabito Francesco Carlo
Published: November 2020

The evolution of engineering applications is increasingly shifting towards the embedded nature, resulting in low-cost solutions, micro/nano dimensional and actuators being exploited as fundamental components to connect the physical nature of information with the abstract one, which is represented in the logical form in a machine. In this context, the scientific community has gained interest in modeling membrane Micro-Electro-Mechanical-Systems (MEMS), leading to a wide diffusion on an industrial level owing to their ease of modeling and realization. Physically, once the external voltage is applied, an electrostatic field, orthogonal to the tangent line of the membrane, is established inside the device, producing an electrostatic pressure that acts on the membrane, deforming it. Evidently, the greater the amplitude of the electrostatic field is, the greater the curvature of the membrane. Thus, it seems natural to consider the amplitude of the electrostatic field proportional to the curvature of the membrane. Starting with this principle, the authors are actively involved in developing a second-order semi-linear elliptic model in 1D and 2D geometries, obtaining important results regarding the existence, uniqueness and stability of solutions as well as evaluating the particular operating conditions of use of membrane MEMS devices. In this context, the idea of providing a survey matures to discussing the similarities and differences between the analytical and numerical results in detail, thereby supporting the choice of certain membrane MEMS devices according to the industrial application. Finally, some original results about the stability of the membrane in 2D geometry are presented and discussed.
Influence of Surface Finishing on Corrosion Behaviour of 3D Printed TiAlV Alloy
Authors: Fojt Jaroslav , Hybášek Vojtěch , Kačenka Zdeněk , Průchová Eva
Published: November 2020

Additive manufacturing is currently one of the promising methods for the fabrication of products of complex shapes. It is also used in medical applications, thanks to technological progress, which also enables the printing of metallic materials. However, the final products often have to undergo a final surface treatment. In this work, the influence of surface finishing on the corrosion behavior of the medical alloy Ti-6Al-4V prepared by the selective laser melting technique is studied. The samples were subjected to mechanical, chemical and electrochemical treatments. Corrosion behavior was investigated using DC and AC electrochemical techniques such as potentiodynamic and potentiostatic curves and electrochemical impedance spectroscopy. Furthermore, the influence of surface treatments on the possibility of localized corrosion attack was evaluated. The results showed that the surface treatments have a positive effect on the corrosion resistance and reduce the risk of crevice corrosion.
High Speed Steel with Iron Addition Materials Sintered by Spark Plasma Sintering
Authors: Madej Marcin , Leszczyńska-Madej Beata , Garbiec Dariusz
Published: November 2020

Attempts were made to describe the effect of the sintering temperature and pure iron powder addition on the properties of high speed steel based materials produced by the spark plasma sintering technique. After sintering, their density, hardness, flexural strength, and tribological properties were determined. The sintered materials were also subjected to microstructural analysis in order to determine the phenomena occurring at the particle contact boundaries during sintering. Based on the analysis of the obtained results, it was found that the mechanical properties and microstructure were mainly influenced by the sintering temperature. Using the temperature of 1000 °C allowed materials with a density close to the theoretical density to be obtained, characterized by a high hardness of about 360 HB and a low wear rate of about 1E-07 g/s.
Prediction of Surface Wrinkle Defect of Welding Wire Steel ER70S-6 in Hot Bar Rolling Process Using Finite Element Method and Experiments
Authors: Liu Qian , Tian Yaqiang , Zhai Jinpo , Tian Lu , Chen Liansheng , Chen Liqing
Published: November 2020

High quality products are demanded due to increasingly fierce market competition. In this paper, the generation of surface wrinkle defect of welding wire steel ER70S-6 was studied by the combination of the experimental method and finite element simulation. Firstly, a thermal compression test was conducted on the Gleeble-3500 thermosimulator under different strain rates and temperatures and a strain dependent Arrhenius-type constitutive function was employed to fit the flow stress–strain curves obtained from the experiments. Then, the elastoplastic constitutive relationship was implemented using radial return mapping algorithm by means of the user subroutine VUMAT of Abaqus/Explicit. A new instability criterion was proposed to predict the possibility of the surface wrinkle defect during the multipass hot bar rolling process. In order to verify the reliability of the finite element model of the six-pass continuous rolling process, the simulated results were compared with experimental data. Finally, the effects of groove width and groove radius on the billet were investigated by the orthogonal test method, and the friction coefficient and rolling temperature. The results show that the groove width and groove radius are key factors to suppress the surface wrinkle defect. Decreasing the groove width can be beneficial for improving the surface quality and reducing the fillet radius. The optimized combination of the rolling process parameters was further applied in an industrial test and the surface quality of the billet was greatly improved.
Quantification of the Dislocation Density, Size, and Volume Fraction of Precipitates in Deep Cryogenically Treated Martensitic Steels
Authors: Antony Ajesh , Schmerl Natalya M. , Sokolova Anna , Mahjoub Reza , Fabijanic Daniel , Stanford Nikki E.
Published: November 2020

Two groups of martensitic alloys were examined for changes induced by deep cryogenic treatment (DCT). The first group was a range of binary and ternary compositions with 0.6 wt % carbon, and the second group was a commercial AISI D2 tool steel. X-ray diffraction showed that DCT made two changes to the microstructure: retained austenite was transformed to martensite, and the dislocation density of the martensite was increased. This increase in dislocation density was consistent for all alloys, including those that did not undergo phase transformation during DCT. It is suggested that the increase in dislocation density may be caused by local differences in thermal expansion within the heterogeneous martensitic structure. Then, samples were tempered, and the cementite size distribution was examined using small angle neutron scattering (SANS) and atom probe tomography. First principles calculations confirmed that all magnetic scattering originated in cementite and not carbon clusters. Quantitative SANS analysis showed a measurable change in cementite size distribution for all alloys as a result of prior DCT. It is proposed that the increase in dislocation density that results from DCT modifies the cementite precipitation through enhanced diffusion rates and increased cementite nucleation sites.
A Resonant Pressure Microsensor with Temperature Compensation Method Based on Differential Outputs and a Temperature Sensor
Authors: Xiang Chao , Lu Yulan , Yan Pengcheng , Chen Jian , Wang Junbo , Chen Deyong
Published: November 2020

This paper presents the analysis and characterization of a resonant pressure microsensor, which employs a temperature compensation method based on differential outputs and a temperature sensor. Leveraging a silicon-on-insulator (SOI) wafer, this microsensor mainly consists of a pressure-sensitive diagram and two resonant beams (electromagnetic driving and electromagnetic induction) to produce a differential output. The resonators were vacuum packaged with a silicon-on-glass (SOG) cap using anodic bonding and the wire interconnection was realized by sputtering an Au film on highly topographic surfaces using a hard mask. After the fabrication of the resonant pressure microsensor, systematic experiments demonstrated that the pressure sensitivity of the presented microsensor was about 0.33 kPa/Hz. Utilizing the differential frequency of the two resonators and the signal from a temperature sensor to replace the two-frequency signals by polynomial fitting, the temperature compensation method based on differential outputs aims to increase the surface fitting accuracy of these microsensors which have turnover points. Employing the proposed compensation approach in this study, the errors were less than 0.02% FS of the full pressure scale (a temperature range of −40 to 85 °C and a pressure range of 200 kPa to 2000 kPa).
Occurrence of Sesquioxide in a Mid-Low Grade Collophane-Sedimentary Apatite Ore from Guizhou, China
Authors: Deng Jie , Zhang Kecheng , He Dongsheng , Zhao Hengqin , Hakkou Rachid , Benzaazoua Mostafa
Published: November 2020

Checking the presence of sesquioxide (Fe2O3, Al2O3) is helpful for its removal in advance. Therefore, the occurrence of sesquioxide in a mid-low grade calcareous-siliceous collophane ore (massive carbonate-apatite, also known as francolite) from Guizhou, China was determined by X-ray fluorescence spectroscopy (XRF), X-ray diffraction (XRD), field emission scanning electron microscope-energy dispersive X-ray spectrometry (FESEM-EDX) and Mineral Liberation Analyzer (MLA). The results show that iron mainly occurs as pyrite FeS2, goethite FeO(OH) and as substitution within dolomite Ca(Mg,Fe)(CO3)2, while aluminum is enriched in muscovite KAl2(AlSi3O10)(OH)2 and also found in apatite (F,CO3)CaPO4 and calcite CaCO3 due to isomorphism or adsorption. All these minerals are fine-grained, among which pyrite and goethite tend to be enriched in larger particles. Intergrowth is predominant in the six minerals’ locking. Pyrite is mainly intergrown with calcite, biotite and also included in apatite and muscovite, while the monomer pyrite appears as semi-automorphic fine grain with the liberation of 56.1%. Apatite particles are mainly intergrown with quartz and calcite. Most of goethite, dolomite, muscovite and calcite form intergrowth with apatite, with contents of 21.7%, 11.1%, 19.5% and 41%, respectively. The removal of pyrite, goethite, dolomite, muscovite and calcite in the ore is the key to reduce the contents of Fe2O3 and Al2O3. In the subsequent beneficiation, the ore must be fully ground. In addition to flotation, magnetic separation can also be considered to remove part of iron in ore. For the removal of aluminum from apatite, leaching method can be considered.
Recent Progress in Antimicrobial Nanomaterials
Authors: Díez-Pascual Ana
Published: November 2020

Bacterial infections are a well-known and serious problem in numerous areas of everyday life, causing death, pain, and huge added costs to healthcare worldwide [...]
In Love with Shaping You—Influential Factors on the Breast Milk Content of Human Milk Oligosaccharides and Their Decisive Roles for Neonatal Development
Authors: Hundshammer Christian , Minge Oliver
Published: November 2020

Human milk oligosaccharides (HMOs) are structurally versatile sugar molecules constituting the third major group of soluble components in human breast milk. Based on the disaccharide lactose, the mammary glands of future and lactating mothers produce a few hundreds of different HMOs implicating that their overall anabolism utilizes rather high amounts of energy. At first sight, it therefore seems contradictory that these sugars are indigestible for infants raising the question of why such an energy-intensive molecular class evolved. However, in-depth analysis of their molecular modes of action reveals that Mother Nature created HMOs for neonatal development, protection and promotion of health. This is not solely facilitated by HMOs in their indigestible form but also by catabolites that are generated by microbial metabolism in the neonatal gut additionally qualifying HMOs as natural prebiotics. This narrative review elucidates factors influencing the HMO composition as well as physiological roles of HMOs on their way through the infant body and within the gut, where a major portion of HMOs faces microbial catabolism. Concurrently, this work summarizes in vitro, preclinical and observational as well as interventional clinical studies that analyzed potential health effects that have been demonstrated by or were related to either human milk-derived or synthetic HMOs or HMO fractions.
The Protective and Long-Lasting Effects of Human Milk Oligosaccharides on Cognition in Mammals
Authors: Docq Sylvia , Spoelder Marcia , Wang Wendan , Homberg Judith R.
Published: November 2020

Over the last few years, research indicated that Human Milk Oligosaccharides (HMOs) may serve to enhance cognition during development. HMOs hereby provide an exciting avenue in the understanding of the molecular mechanisms that contribute to cognitive development. Therefore, this review aims to summarize the reported observations regarding the effects of HMOs on memory and cognition in rats, mice and piglets. Our main findings illustrate that the administration of fucosylated (single or combined with Lacto-N-neoTetraose (LNnT) and other oligosaccharides) and sialylated HMOs results in marked improvements in spatial memory and an accelerated learning rate in operant tasks. Such beneficial effects of HMOs on cognition already become apparent during infancy, especially when the behavioural tasks are cognitively more demanding. When animals age, its effects become increasingly more apparent in simpler tasks as well. Furthermore, the combination of HMOs with other oligosaccharides yields different effects on memory performance as opposed to single HMO administration. In addition, an enhanced hippocampal long-term potentiation (LTP) response both at a young and at a mature age are reported as well. These results point towards the possibility that HMOs administered either in singular or combination forms have long-lasting, beneficial effects on memory and cognition in mammals.
Influence of Fermented Red Clover Extract on Skeletal Muscle in Early Postmenopausal Women: A Double-Blinded Cross-Over Study
Authors: Oxfeldt Mikkel , Dalgaard Line Barner , Risikesan Jeyanthini , Johansen Frank Ted , Hansen Mette
Published: November 2020

Objective: To investigate effects of supplementation with a fermented red clover (RC) extract on signaling proteins related to muscle protein synthesis and breakdown at rest and in response to a resistance exercise bout. Methods: Ten postmenopausal women completed a double-blinded cross-over trial with two different intervention periods performed in random order: (A) RC extract twice daily for 14 days, and (B) placebo drink twice daily for 14 days. The intervention periods were separated by a two-week washout period. After each intervention period a muscle tissue sample was obtained before and three hours after a one-legged resistance exercise bout. Muscle strength was assessed before and after each intervention period. Results: Protein expression of FOXO1 and FOXO3a, two key transcription factors involved in protein degradation, were significantly lower and HSP27, a protein involved in cell protection and prevention of protein aggregation was significantly higher following RC extract compared to placebo. No significant treatment × time interaction was observed for muscle protein expression in response to exercise. However, p-mTOR, p-p70S6k and HSP90 protein content were significantly increased in response to exercise in both groups. Conclusion: This study demonstrates that RC extract supplementation downregulates molecular markers of muscle protein degradation compared to placebo in postmenopausal women.
Sex-Specific Effects of Chronic Creatine Supplementation on Hippocampal-Mediated Spatial Cognition in the 3xTg Mouse Model of Alzheimer’s Disease
Authors: Snow Wanda M. , Cadonic Chris , Cortes-Perez Claudia , Adlimoghaddam Aida , Roy Chowdhury Subir K. , Thomson Ella , Anozie Adama , Bernstein Michael J. , Gough Kathleen , Fernyhough Paul , Suh Miyoung , Albensi Benedict C.
Published: November 2020

The creatine (Cr) energy system has been implicated in Alzheimer’s disease (AD), including reductions in brain phosphoCr and Cr kinase, yet no studies have examined the neurobehavioral effects of Cr supplementation in AD, including the 3xTg mouse model. This studied investigated the effects of Cr supplementation on spatial cognition, plasticity- and disease-related protein levels, and mitochondrial function in the 3xTg hippocampus. Here, 3xTg mice were fed a control or Cr-supplemented (3% Cr (w/w)) diet for 8–9 weeks and tested in the Morris water maze. Mitochondrial oxygen consumption (Seahorse) and protein levels (Western blots) were measured in the hippocampus in subsets of mice. Overall, 3xTg females exhibited impaired memory as compared to males. In females, Cr supplementation decreased escape latency and was associated with increased spatial search strategy use. In males, Cr supplementation decreased the use of spatial search strategies. Pilot data indicated mitochondrial enhancements with Cr supplementation in both sexes. In females, Cr supplementation increased CREB phosphorylation and levels of IκB (NF-κB suppressor), CaMKII, PSD-95, and high-molecular-weight amyloid β (Aβ) species, whereas Aβ trimers were reduced. These data suggest a beneficial preventative effect of Cr supplementation in females and warrant caution against Cr supplementation in males in the AD-like brain.
Childhood Malnutrition and Association of Lean Mass with Metabolome and Hormone Profile in Later Life
Authors: Gonzales Gerard Bryan , Lelijveld Natasha , Bourdon Celine , Chimwezi Emmanuel , Nyirenda Moffat J. , Wells Jonathan C. , Kerac Marko , Bandsma Robert H. J.
Published: November 2020

This study aimed to determine the associations of targeted metabolomics and hormone profiles data with lean mass index (LMI), which were estimated using bioelectrical impedance, in survivors of child severe malnutrition (SM) (n = 69) and controls (n = 77) in Malawi 7 years after being treated. Linear associations between individual metabolite or hormone and LMI were determined, including their interaction with nutrition status 7 years prior. Path analysis was performed to determine structural associations. Lastly, predictive models for LMI were developed using the metabolome and hormone profile by elastic net regularized regression (EN). Metabolites including several lipids, amino acids, and hormones were individually associated (p < 0.05 after false discovery rate correction) with LMI. However, plasma FGF21 (Control: β = −0.02, p = 0.59; Case: β = −0.14, p < 0.001) and tryptophan (Control: β = 0.15, p = 0.26; Case: β = 0.70, p < 0.001) were associated with LMI among cases but not among controls (both interaction p-values < 0.01). Moreover, path analysis revealed that tryptophan mediates the association between child SM and LMI. EN revealed that most predictors of LMI differed between groups, further indicating altered metabolic mechanisms driving lean mass accretion among SM survivors later in life.
Iron Status is Associated with Mood, Cognition, and Functional Ability in Older Adults: A Cross-Sectional Study
Authors: Portugal-Nunes Carlos , Castanho Teresa Costa , Amorim Liliana , Moreira Pedro Silva , Mariz José , Marques Fernanda , Sousa Nuno , Santos Nadine Correia , Palha Joana Almeida
Published: November 2020

Several conditions are risk factors for iron deficiency (ID), some of which are highly prevalent in older individuals. Despite the amount of evidence pointing for a role of ID in cognition, mood and physical functional ability, the research addressing these associations in older individuals is still scarce. In the present study, 162 older community-dwelling individuals (29.53% classified as ID) were enrolled in a cross-sectional analysis and characterized regarding cognition, mood, functional ability, general nutritional intake and iron status. Assessment of iron status was performed using several blood biomarkers. Storage and erythropoiesis dimensions were positively associated with memory, along with an interaction (moderator effect) between iron storage and nutritional status. A more depressed mood was negatively associated with (iron) transport, transport saturation and erythropoiesis dimensions, and functional tiredness was positively associated with the erythropoiesis dimension. These observations indicate that lower iron status is associated with depressive mood, functional tiredness and poorer memory ability, with the latter moderated by nutritional status. These findings suggest that using iron as a continuous variable may be useful in finding associations with iron homeostasis, eventually missed when iron levels are considered within the usual classification groups.
Induction of Fusarium lytic Enzymes by Extracts from Resistant and Susceptible Cultivars of Pea (Pisum sativum L.)
Authors: Perincherry Lakshmipriya , Ajmi Chaima , Oueslati Souheib , Waśkiewicz Agnieszka , Stępień Łukasz
Published: November 2020

Being pathogenic fungi, Fusarium produce various extracellular cell wall-degrading enzymes (CWDEs) that degrade the polysaccharides in the plant cell wall. They also produce mycotoxins that contaminate grains, thereby posing a serious threat to animals and human beings. Exposure to mycotoxins occurs through ingestion of contaminated grains, inhalation and through skin absorption, thereby causing mycotoxicoses. The toxins weaken the host plant, allowing the pathogen to invade successfully, with the efficiency varying from strain to strain and depending on the plant infected. Fusariumoxysporum predominantly produces moniliformin and cyclodepsipeptides, whereas F. proliferatum produces fumonisins. The aim of the study was to understand the role of various substrates and pea plant extracts in inducing the production of CWDEs and mycotoxins. Additionally, to monitor the differences in their levels when susceptible and resistant pea plant extracts were supplemented. The cultures of F. proliferatum and F. oxysporum strains were supplemented with various potential inducers of CWDEs. During the initial days after the addition of substrates, the fungus cocultivated with pea extracts and other carbon substrates showed increased activities of β-glucosidase, xylanase, exo-1,4-glucanase and lipase. The highest inhibition of mycelium growth (57%) was found in the cultures of F. proliferatum strain PEA1 upon the addition of cv. Sokolik extract. The lowest fumonisin content was exhibited by the cultures with the pea extracts and oat bran added, and this can be related to the secondary metabolites and antioxidants present in these substrates.
Gastrointestinal Mechanisms Underlying the Cardiovascular Effect of Metformin
Authors: Borg Malcolm J. , Rayner Christopher K. , Jones Karen L. , Horowitz Michael , Xie Cong , Wu Tongzhi
Published: November 2020

Metformin, the most widely prescribed drug therapy for type 2 diabetes, has pleiotropic benefits, in addition to its capacity to lower elevated blood glucose levels, including mitigation of cardiovascular risk. The mechanisms underlying the latter remain unclear. Mechanistic studies have, hitherto, focused on the direct effects of metformin on the heart and vasculature. It is now appreciated that effects in the gastrointestinal tract are important to glucose-lowering by metformin. Gastrointestinal actions of metformin also have major implications for cardiovascular function. This review summarizes the gastrointestinal mechanisms underlying the action of metformin and their potential relevance to cardiovascular benefits.
Atopic Dermatitis as a Multifactorial Skin Disorder. Can the Analysis of Pathophysiological Targets Represent the Winning Therapeutic Strategy?
Authors: Magnifico Irene , Petronio Petronio Giulio , Venditti Noemi , Cutuli Marco Alfio , Pietrangelo Laura , Vergalito Franca , Mangano Katia , Zella Davide , Di Marco Roberto
Published: November 2020

Atopic dermatitis (AD) is a pathological skin condition with complex aetiological mechanisms that are difficult to fully understand. Scientific evidence suggests that of all the causes, the impairment of the skin barrier and cutaneous dysbiosis together with immunological dysfunction can be considered as the two main factors involved in this pathological skin condition. The loss of the skin barrier function is often linked to dysbiosis and immunological dysfunction, with an imbalance in the ratio between the pathogen Staphylococcus aureus and/or other microorganisms residing in the skin. The bibliographic research was conducted on PubMed, using the following keywords: ‘atopic dermatitis’, ‘bacterial therapy’, ‘drug delivery system’ and ‘alternative therapy’. The main studies concerning microbial therapy, such as the use of bacteria and/or part thereof with microbiota transplantation, and drug delivery systems to recover skin barrier function have been summarized. The studies examined show great potential in the development of effective therapeutic strategies for AD and AD-like symptoms. Despite this promise, however, future investigative efforts should focus both on the replication of some of these studies on a larger scale, with clinical and demographic characteristics that reflect the general AD population, and on the process of standardisation, in order to produce reliable data.
Effects of Irrigation with Different Sources of Water on Growth, Yield and Essential Oil Compounds in Oregano
Authors: Virga Giuseppe , Sabatino Leo , Licata Mario , Tuttolomondo Teresa , Leto Claudio , La Bella Salvatore
Published: November 2020

Aromatic plants can benefit from the use of treated wastewater to satisfy their water requirements, but the effects on the essential oil yield and quality need an assessment. The aims of this study were to assess the effects of freshwater and treated wastewater obtained from a Sicilian (Italy) pilot-scale horizontal subsurface flow constructed wetland system on plant growth and yield, essential oil yield and composition of oregano (Origanum vulgare ssp. hirtum (Link) Ietswaart) and soil characteristics. The system had a total surface area of 100 m2 and was planted with giant reed and umbrella sedge. An experimental open field of oregano was set up close to the system. Two years and two different sources of irrigation water were tested in a split-plot design for a two-factor experiment. Treated wastewater was characterized by higher values of mineral and organic constituents than freshwater. The results highlight that short-term irrigation with freshwater and treated wastewater, in both years, led to increased plant growth, dry weight and essential oil yield of oregano plants. However, it did not significantly affect the essential oil content and composition in comparison with the control. Furthermore, the year and source of irrigation water did not significantly vary the chemical composition of the soil. Our results suggest that treated wastewater can be considered an alternative to freshwater for the cultivation of oregano due to the fact that it does not greatly influence the yield quality and quantity of this species in the short-term.
Investigation of Acetone Vapour Sensing Properties of a Ternary Composite of Doped Polyaniline, Reduced Graphene Oxide and Chitosan Using Surface Plasmon Resonance Biosensor
Authors: Usman Fahad , Dennis John Ojur , Mkawi E M , Al-Hadeethi Yas , Meriaudeau Fabrice , Ferrell Thomas L. , Aldaghri Osamah , Sulieman Abdelmoneim
Published: November 2020

This work reports the use of a ternary composite that integrates p-Toluene sulfonic acid doped polyaniline (PANI), chitosan, and reduced graphene oxide (RGO) as the active sensing layer of a surface plasmon resonance (SPR) sensor. The SPR sensor is intended for application in the non-invasive monitoring and screening of diabetes through the detection of low concentrations of acetone vapour of less than or equal to 5 ppm, which falls within the range of breath acetone concentration in diabetic patients. The ternary composite film was spin-coated on a 50-nm-thick gold layer at 6000 rpm for 30 s. The structure, morphology and chemical composition of the ternary composite samples were characterized by FTIR, UV-VIS, FESEM, EDX, AFM, XPS, and TGA and the response to acetone vapour at different concentrations in the range of 0.5 ppm to 5 ppm was measured at room temperature using SPR technique. The ternary composite-based SPR sensor showed good sensitivity and linearity towards acetone vapour in the range considered. It was determined that the sensor could detect acetone vapour down to 0.88 ppb with a sensitivity of 0.69 degree/ppm with a linearity correlation coefficient of 0.997 in the average SPR angular shift as a function of the acetone vapour concentration in air. The selectivity, repeatability, reversibility, and stability of the sensor were also studied. The acetone response was 87%, 94%, and 99% higher compared to common interfering volatile organic compounds such as propanol, methanol, and ethanol, respectively. The attained lowest detection limit (LOD) of 0.88 ppb confirms the potential for the utilisation of the sensor in the non-invasive monitoring and screening of diabetes.
Development of Energy-Efficient Superhydrophobic Polypropylene Fabric by Oxygen Plasma Etching and Thermal Aging
Authors: Kim Shinyoung , Oh Ji-Hyun , Park Chung Hee
Published: November 2020

This study developed a human-friendly energy-efficient superhydrophobic polypropylene (PP) fabric by oxygen plasma etching and short-term thermal aging without additional chemicals. The effect of the microroughness on the superhydrophobicity was examined by adjusting the weave density. After the PP fabric was treated with oxygen plasma etching for 15 min and thermal aging at 120 °C for 1 h (E15H120 1 h), the static contact and shedding angles were 162.7° ± 2.4° and 5.2° ± 0.7° and the energy consumption was 136.4 ± 7.0 Wh. Oxygen plasma etching for 15 min and thermal aging at 120 °C for 24 h (E15H120 24 h) resulted in a static contact and shedding angle of 180.0° ± 0.0° and 1.8° ± 0.2° and energy consumption of 3628.5 ± 82.6 Wh. E15H120 1 h showed a lower shedding angle but had a higher sliding angle of 90°. E15H120 24 h exhibited shedding and sliding angles of less than 10°. Regardless of the thermal aging time, superhydrophobicity was higher in high-density fabrics than in low-density fabrics. The superhydrophobic PP fabric had a similar water vapor transmission rate and air permeability with the untreated PP fabric, and it showed a self-heading property after washing followed by tumble drying and hot pressing.
Popular Songs, Melodies from the Dead: Moving beyond Historicism with the Buddhist Ethics and Aesthetics of Pin Peat and Cambodian Hip Hop
Authors: Dyer Jeffrey
Published: November 2020

This article illustrates how the aesthetics of two types of Cambodian music—pin peat and Cambodian hip hop—enact Cambodian–Buddhist ethics and function as ritual practices through musicians’ recollections of deceased teachers’ musical legacies. Noting how prevalent historicist and secular epistemologies isolate Cambodian and, more broadly, Southeast Asian musical aesthetics from their ethical and ritual functions, I propose that analyses focusing on Buddhist ethics more closely translate the moral, religious, and ontological aspects inherent in playing and listening to Cambodian music. I detail how Cambodian musicians’ widespread practices of quoting deceased teachers’ variations, repurposing old musical styles, and reiterating the melodies and rhythms played by artistic ancestors have the potential to function as Buddhist rituals, whether those aesthetic and stylistic features surface in pin peat songs or in hip hop. Those aesthetic practices entail a modality of being historical that partially connects with but exceeds historicism’s approach to Buddhism, temporality, and history by enacting relations of mutual care that bring the living and dead to be ontologically coeval. Such relational practices bring me to conclude with a brief discussion rethinking what post-genocide remembrance sounds like and feels like.
Remote Sensing of Ecosystem Structure: Fusing Passive and Active Remotely Sensed Data to Characterize a Deltaic Wetland Landscape
Authors: Peters Daniel , Niemann K. Olaf , Skelly Robert
Published: November 2020

A project was constructed to integrate remotely sensed data from multiple sensors and platforms to characterize range of ecosystem characteristics in the Peace–Athabasca Delta in Northern Alberta, Canada. The objective of this project was to provide a framework for the processing of multisensor data to extract ecosystem information describing complex deltaic wetland environments. The data used in this study was based on a passive satellite-based earth observation multispectral sensor (Sentinel-2) and airborne discrete light detection and ranging (LiDAR). The data processing strategy adopted here allowed us to employ a data mining approach to grouping of the input variables into ecologically meaningful clusters. Using this approach, we described not only the reflective characteristics of the cover, but also ascribe vertical and horizontal structure, thereby differentiating spectrally similar, but ecologically distinct, ground features. This methodology provides a framework for assessing the impact of ecosystems on radiance, as measured by Earth observing systems, where it forms the basis for sampling and analysis. This final point will be the focus of future work.
Spatial Analysis of Land Subsidence in the San Luis Potosi Valley Induced by Aquifer Overexploitation Using the Coherent Pixels Technique (CPT) and Sentinel-1 InSAR Observation
Authors: Navarro-Hernández María Inés , Tomás Roberto , Lopez-Sanchez Juan M. , Cárdenas-Tristán Abraham , Mallorquí Jordi J.
Published: November 2020

The San Luis Potosi metropolitan area has suffered considerable damage from land subsidence over the past decades, which has become visible since 1990. This paper seeks to evaluate the effects of groundwater withdrawal on land subsidence in the San Luis Potosi Valley and the development of surface faults due to the differential compaction of sediments. For this purpose, we applied the Coherent Pixels Technique (CPT), a Persistent Scatterer Interferometry (PSI) technique, using 112 Sentinel-1 acquisitions from October 2014 to November 2019 to estimate the deformation rate. The results revealed that the deformation areas in the municipality of Soledad de Graciano Sánchez mostly exhibit subsidence values between −1.5 and −3.5 cm/year; whereas in San Luis Potosi these values are between −1.8 and −4.2 cm/year. The PSI results were validated by five Global Navigation Satellite System (GNSS) benchmarks available, providing a data correlation between the results obtained with both techniques of 0.986. This validation suggests that interferometric derived deformations agree well with results obtained from GNSS data. The strong relationship between trace fault, land subsidence,e and groundwater extraction suggests that groundwater withdrawal is resulting in subsidence induced faulting, which follows the pattern of structural faults buried by sediments.