bluuebunny/crossref_metadata_2025 huggingface dataset:
A Nonlinear UAV Control Tuning Under Communication Delay using HPC Strategies in Parameters Space
Authors: Fagundes-Junior Leonardo , Canesche Michael , Ferreira Ricardo , Brandão Alexandre
Published: December 2021

In practical applications, the presence of delays can deteriorate the performance of the control system or even cause plant instability. However, by properly controlling these delays, it is possible to improve the performance of the mechanism. The present work is based on a proposal to analyze the asymptotic stability and convergence of a quadrotor robot, an unmanned aerial vehicle (UAV), on the performance of a given task, under time delay in the data flow. The effects of the communication delay problem, as well as the response-signal behavior of the quadrotors in the accomplishment of positioning mission are presented and analyzed from the insertion of fixed time delay intervals in the UAVs' data collected by its sensors system. Due to the large search space in the set of parameter combinations and the high computational cost required to perform such an analysis by sequentially executing thousands of simulations, this work proposes an open source GPU-based implementation to simulate the robot behavior. Experimental results show a speedup up to 4900x in comparison to MATLAB® implementation. The implement is available in Colab Google platform.
Las Salas de Prensa Virtual como herramientas de Relaciones Públicas para la comunicación con los medios en Cuba. Un estado de la cuestión / Virtual Press Room as Public Relations tool for communication with media in Cuba. A state of affairs
Authors: Taboada-Castell Claudia , Merchán-Mota Iker , Cantalapiedra González María-José
Published: December 2021

Public Relations have found in digital platforms an ideal device to build contact and interactivity with corporation's audiences. Within the field, new possibilities emerge to address the issue of generating interactivity with communication media, which has always been a core activity of Public Relations offices. Over the last decade, the Cuban institutional and communicative scenario has witnessed an upsurge of Press Cabinets and Communication Offices, which are expanding their traditional functions mainly due to digitization and hypermedia convergence. Thus, new resources like Virtual Press Rooms aim to assist corporations in their quest to build interactive channels for contact with media and citizenship, to manage information flows with journalists and to promote the dialogue with the stakeholders. These tools are considered a natural evolvement of the traditional routines of communication offices to enhance interactive channels and nurtured relationships with press officers. Many researchers have pointed out the relevant role of Virtual Press Rooms as substitutes for common PR strategies like press kit and mailing.
This research analyzes the integration of Virtual Press Rooms within the main organism of Cuban state’s central administration. This research has been carried out using a quantitative content analysis, based on a categorical system validated by the Bitartez Group of the Basque University System for developing similar researches in the field. The study assesses the common features of Virtual Press Rooms in Cuban corporations and its adaptation to Cuban journalistic and communicative landscape. The results of the study show that Cuban Online Press Rooms perform as a container for files and corporate content, while exalting a documentary function. In many cases, the informative role is prioritized, while the contents designed for media are relegated to less visible spaces within the website. Even though they improve the access to relevant and quality information that facilitates journalistic practices, they still lack of a better approach to nurture the interactions between journalists and corporate sources.
The whole analysis shows that Cuban corporations do not take full advantage of digital capabilities to nurture the information flows and the interactions between the organization and their stakeholders. Whether it is suitable to assess that Cuban communication`s practices are, indeed, in a process of transition to the digital landscape, it is still relevant to find out if the limitations exposed in the previous paragraphs obey to some strategical and political-ideological conditioning factors.
Normalized Statistical Algorithm for Afaan Oromo Word Sense Disambiguation
Authors:   Department of Information Technology, College of Computing and Informatics, Wolkite University, Ethiopia, Abafogi Abdo Ababor
Published: December 2021

Language is the main means of communication used by human. In various situations, the same word can mean differently based on the usage of the word in a particular sentence which is challenging for a computer to understand as level of human. Word Sense Disambiguation (WSD), which aims to identify correct sense of a given ambiguity word, is a long-standing problem in natural language processing (NLP). As the major aim of WSD is to accurately understand the sense of a word in particular context, can be used for the correct labeling of words in natural language applications. In this paper, I propose a normalized statistical algorithm that performs the task of WSD for Afaan Oromo language despite morphological analysis The propose algorithm has the power to discriminate ambiguous word’s sense without windows size consideration, without predefined rule and without utilize annotated dataset for training which minimize a challenge of under resource languages. The proposed system tested on 249 sentences with precision, recall, and F-measure. The overall effectiveness of the system is 80.76% in F-measure, which implies that the proposed system is promising on Afaan Oromo that is one of under resource languages spoken in East Africa. The algorithm can be extended for semantic text similarity without modification or with a bit modification. Furthermore, the forwarded direction can improve the performance of the proposed algorithm.
Uma Lisboa só dele(s). Processos artivistas de recriação de paisagens sonoras contemporâneas
Authors: Guerra Paula
Published: December 2021

Este artigo expõe a trajetória de um músico português - Tó Trips – e da sua última banda – os Dead Combo – no intuito de fundir um percurso musical com uma paisagem sonora na linha da concetualização de Schafer (2012). Socorrendo-nos, em termos metodológicos, de uma história de vida e de materiais documentais, iremos estabelecer uma sincronia entre cidade, sons, criação musical e intervenção artística. Os Dead Combo e Tó Trips são, no quadro deste artigo, os (re)criadores ativos de Lisboa, permitindo, simultaneamente, estabelecer algumas asserções sobre o valor do som e da música como carburantes de identidades coletivas e individuais; e a potenciação da construção de imaginários simbólicos e afetivos face a um espaço urbano na senda de Frith (1996). Num processo que alguns designam como spatial turn (STAHL, 2004) nas últimas décadas, iremos evidenciar que a globalização parece ter renovado a ênfase no local, encorajando reconstruções identitárias através do surgimento de novas expressões artísticas de vínculo à cidade e, portanto, de uma re-imaginação da cidade, partindo de uma produção artística territorialmente ancorada, vivida e sentida. E tal ênfase parece revestir-se de uma urgência crítica nestes tempos distópicos.
História, Literatura e a escrita de mulheres africanas e afro-diaspóricas: uma entrevista com Ana Rita Santiago
Authors: Cassiano Tathiana Cristina da Silva Anizio
Published: December 2021

Drª Ana Rita Santiago é professora Associada aposentada da Universidade Federal do Recôncavo da Bahia (UFRB). Docente do Programa de Pós-Graduação Crítica Cultural, da Universidade do Estado da Bahia (UNEB), Campus de Alagoinhas-BA. Estágio pós-doutoral na Université René Paris Descartes, Paris V, Sorbonne, Paris-França. Doutora em Letras e Linguística pela Universidade Federal da Bahia (UFBA). Membro do GT Mulher e Literatura da Associação Nacional de Pós-Graduação e Pesquisa em Letras e Linguística. Foi Pró-Reitora de Extensão da UFRB e Presidente da Associação de Pesquisadores(as) Negro(a)s da Bahia. Já publicou os seguintes livros: Vozes Literárias Negras (2012); Cartografias em Construção – Algumas Escritoras de Moçambique (2019); Águas – Moradas de Memórias (2020).
Nesta entrevista, realizada no dia 27 de outubro de 2021 por videoconferência na Plataforma Zoom, a professora Ana Rita fala da importância da Literatura de mulheres nas Áfricas e no Brasil e como estas subverteram o paradigma da escrita literária no que tange à representação de mulheres e dos seus papéis na sociedade. Ana Rita ainda aborda sobre as potencialidades e desafios do diálogo entre a História e a Literatura.
Etnoconhecimento das plantas indicadoras na paisagem do subsistema faxinalense ‘terras de plantar’, Rio Azul - PR
Authors: Strachulski Juliano , Floriani Nicolas
Published: December 2021

O presente artigo tem por objetivo compreender o etnoconhecimento das plantas indicadoras em relação com a paisagem das ‘terras de plantar’ do Faxinal Taquari dos Ribeiros, Rio Azul - PR. Metodologicamente, o trabalho teve início com a aplicação de um teste piloto. Em seguida, utilizou-se de entrevistas de caráter aberto, semi-estruturado e não estruturado. Posteriormente, realizou-se uma turnê guiada (etnocaminhada) para a coleta das espécies indicadoras e sua identificação em laboratório. Deste modo, foi possível elencar 42 etnoespécies, sendo 32 relacionadas somente à qualidade das terras e 10 correlacionadas diretamente aos tipos de terras (Branca, Preta e Roxa). A classificação da vegetação espontânea e sua relação com as terras revela que a lógica avaliativa da potencialidade produtiva da paisagem se dá de maneira sintética. Na paisagem se verifica, portanto, uma relação inextricável entre os grupos humanos e a natureza, em que se apresentam as feições, conteúdos e saberes desta interação.
Balanced assessment of growth disorders using clinical, endocrinological, and genetic approaches
Authors: Savage Martin Oswald , Storr Helen Louise
Published: December 2021

Determining the pathogenesis of pediatric growth disorders is often challenging. In many cases, no pathogenesis is identified, and a designation of idiopathic short stature is used. The investigation of short stature requires a combination of clinical, endocrinological, and genetic evaluation. The techniques used are described, with equal importance being given to each of the 3 approaches. Clinical skills are essential to elicit an accurate history, family pedigree, and symptoms of body system dysfunction. Endocrine assessment requires hormonal determination for the diagnosis of hormone deficiency and initiation of successful replacement therapy. Genetic analysis has added a new dimension to the investigation of short stature and now uses next-generation sequencing with a candidate gene approach to confirm probable recognizable monogenic disorders and exome sequencing for complex phenotypes of unknown origin. Using the 3 approaches of clinical, endocrine, and genetic probes with equal status in the hierarchy of investigational variables provides the clinician with the highest chance of identifying the correct causative pathogenetic mechanism in a child presenting with short stature of unknown origin.
#She’sOnly16: Análisis crítico del discurso de las publicaciones en Twitter sobre un caso de violación colectiva en Río de Janeiro
Authors: Rabelo Nair
Published: December 2021

Este artículo investiga los discursos sobre la violencia contra las mujeres publicados en Twitter y su interfaz con las políticas públicas a partir de la aportación teórico-metodológica del Análisis Crítico del Discurso (ACD). El análisis textual se centra en un caso concreto: la violación colectiva de una joven de 16 años en Río de Janeiro, Brasil, el 21 de mayo de 2016 y la divulgación de imágenes de este crimen. El caso provocó un gran revuelo en Brasil. El crimen se conoció y se denunció debido a la divulgación en Twitter de un vídeo de la violación, que fue grabado por uno de los agresores. Este artículo pretende evaluar el impacto potencial de las redes sociales en el debate de la violencia contra las mujeres y en la acción de respuesta del poder público brasileño.
Autoidentidad y discursos mediáticos de la discapacidad en la prensa deportiva digital
Authors: Meléndez-Labrador Sandra
Published: December 2021

Esta investigación aborda la relación entre medios y discapacidad desde el área del periodismo deportivo con la cobertura de la prensa digital colombiana de los Juegos Paralímpicos Río 2016. El estudio analizó los significados asignados por los deportistas paralímpicos colombianos a las noticias publicadas por los medios digitales sobre su participación, así como los elementos de dichas noticias y la manera como influyeron en su autoidentificación mediática. Desde un enfoque crítico-interpretativo, la pesquisa se desarrolló en dos fases: en la primera se realizó un análisis textual de 559 noticias digitales publicadas sobre el tema; en un segundo momento, los datos obtenidos se confrontaron con las y los 45 protagonistas de las noticias a través de entrevistas semiestructuradas. Se constató que la mayoría de las y los atletas carecen de conocimiento y adopción del modelo progresista de representación mediática de la discapacidad, por lo que valoran los discursos mediáticos supercrip con los que son representados como héroes o modelos de inspiración, no por sus logros deportivos, sino por su capacidad de superación “a pesar” de la discapacidad. Se concluye que, en la medida en que los medios digitales los muestran como atletas, especialmente que inspiran a otras personas con y sin discapacidad, incrementan las posibilidades de que estos deportistas desarrollen una autoidentidad mediática. En tal sentido, a partir de la valoración positiva o negativa de determinados elementos de las noticias, los deportistas se sintieron o no autoidentificados mediáticamente de manera impuesta, asumida, negociada o rechazada.
Criptoginia: una palabra nueva, un concepto para investigar
Authors: Pozo-Sánchez Begoña , Padilla-Carmona Carles
Published: December 2021

La ocultación de los referentes femeninos en los diferentes ámbitos de prestigio social y, por tanto, la desaparición o minusvaloración de las aportaciones de las mujeres en cualquier espacio de poder donde se valore la visibilidad y la notoriedad es un fenómeno muy antiguo al que nadie le había puesto nombre hasta ahora, pero que hemos sufrido sistemáticamente como sociedades. Los autores han creado un concepto que, de forma clara, muestra esta carencia. La palabra criptoginia se compone de dos elementos griegos fácilmente identificables en otras palabras de nuestras lenguas: crypto (ocultar) y gyné (mujer). En este trabajo, además de la argumentación etimológica y lingüística, se presentan una serie de razones culturales y sociológicas que justifican la oportunidad del nuevo término para, finalmente, establecer unas líneas de actuación enmarcadas en la articulación de una propuesta didáctica.
¿Vecinas, policías o expertas? Las fuentes informativas en las noticias sobre feminicidios
Authors: Novo Arbona Ainhoa , Peña Fernández Simón , Eguskiza Sesumaga Leyre , Jiménez Martín Eva , Martínez Odriozola Lucía
Published: December 2021

El adecuado uso de las fuentes informativas se ha identificado tradicionalmente como uno de los elementos más relevantes a la hora de informar sobre los asesinatos machistas. Sin embargo, en la mayoría de las ocasiones, estos tratamientos informativos se han caracterizado por la escasez de personas expertas que ofrezcan una visión más social del hecho. Este artículo recoge los resultados de una investigación en la que se analizaron 381 informaciones publicadas en los siete principales diarios de Euskadi relativas a los feminicidios ocurridos entre los años 2015 y 2017 y se profundizó con diez entrevistas a personas responsables de medios. Los resultados de la investigación muestran que el vecindario y las familias continúan siendo la fuente informativa más habitual, por delante de las instituciones políticas y las asociaciones feministas, y las fuentes policiales y judiciales. Por su parte, los responsables de los medios de comunicación son conscientes de los peligros del uso del vecindario como fuente informativa, y reconocen las dificultades para la correcta cobertura de este tipo de informaciones derivadas de las rutinas periodísticas.
Violencia y víctimas: Evaluando el efecto de los códigos deontológicos en las representaciones de la esquizofrenia masculina en los periódicos nacionales del Reino Unido (2013-2016)
Authors: Perkins Keighley , Lorenzo-Dus Nuria
Published: December 2021

La prensa británica se orienta hacia una información responsable mediante directrices elaboradas por organizaciones como el Sindicato Nacional de Periodistas (NUJ). En lo que respecta a la salud mental, estas directrices aconsejan, entre otros, evitar los vínculos entre la salud mental y la violencia, así como el uso de representaciones que estigmaticen. Sin embargo, el cumplimiento de estas recomendaciones no siempre se consigue de forma sistemática. Este estudio adopta el marco de análisis discursivo de los valores noticiosos (DNVA) (Bednarek & Caple, 2017) para examinar las representaciones visuales y textuales de los hombres con esquizofrenia en la prensa del Reino Unido a la luz de las directrices de salud mental del NUJ. En concreto, analizamos los valores noticiosos extraídos del texto y las imágenes contenidas en todos los artículos sobre varones con esquizofrenia publicados en The Daily Mail, The Guardian, The Independent y The Metro el año anterior y los dos años posteriores a la publicación de la edición actual de las directrices del NUJ (2014). Nuestros resultados muestran la prevalencia de cuatro valores noticiosos: consonancia, negatividad, personalización y positividad. Estos valores sugieren una correspondencia entre la perpetuación de los estereotipos negativos asociados a la esquizofrenia (consonancia/negatividad) y la exploración más positiva de las experiencias de los hombres con esta condición (personalización/positividad). Antes de la publicación de las directrices, los ejemplos de positividad y personalización son más frecuentes en los textos de los cuatro periódicos que los de consonancia y negatividad. Sin embargo, ocurre lo contrario tras la publicación de las directrices. En cuanto a las representaciones visuales, los valores de negatividad y de personalización son más frecuentes antes de la publicación, mientras que, después de la publicación, la frecuencia de los valores de consonancia y negatividad es similar. Nuestro estudio concluye que la adopción de las directrices de la NUJ ha sido escasa y propone que, para lograr representaciones más sensibles de la salud mental, se requiere un mayor uso de detalles positivos y contextuales de individuos con esquizofrenia.
Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays
Authors: Stopsack Konrad H , Tyekucheva Svitlana , Wang Molin , Gerke Travis A , Vaselkiv J Bailey , Penney Kathryn L , Kantoff Philip W , Finn Stephen P , Fiorentino Michelangelo , Loda Massimo , Lotan Tamara L , Parmigiani Giovanni , Mucci Lorelei A
Published: December 2021

Tissue microarrays (TMAs) have been used in thousands of cancer biomarker studies. To what extent batch effects, measurement error in biomarker levels between slides, affects TMA-based studies has not been assessed systematically. We evaluated 20 protein biomarkers on 14 TMAs with prospectively collected tumor tissue from 1448 primary prostate cancers. In half of the biomarkers, more than 10% of biomarker variance was attributable to between-TMA differences (range, 1–48%). We implemented different methods to mitigate batch effects (R package batchtma), tested in plasmode simulation. Biomarker levels were more similar between mitigation approaches compared to uncorrected values. For some biomarkers, associations with clinical features changed substantially after addressing batch effects. Batch effects and resulting bias are not an error of an individual study but an inherent feature of TMA-based protein biomarker studies. They always need to be considered during study design and addressed analytically in studies using more than one TMA.
FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons
Authors: Hale Caryn R , Sawicka Kirsty , Mora Kevin , Fak John J , Kang Jin Joo , Cutrim Paula , Cialowicz Katarzyna , Carroll Thomas S , Darnell Robert B
Published: December 2021

Neurons rely on translation of synaptic mRNAs in order to generate activity-dependent changes in plasticity. Here, we develop a strategy combining compartment-specific crosslinking immunoprecipitation (CLIP) and translating ribosome affinity purification (TRAP) in conditionally tagged mice to precisely define the ribosome-bound dendritic transcriptome of CA1 pyramidal neurons. We identify CA1 dendritic transcripts with differentially localized mRNA isoforms generated by alternative polyadenylation and alternative splicing, including many that have altered protein-coding capacity. Among dendritic mRNAs, FMRP targets were found to be overrepresented. Cell-type-specific FMRP-CLIP and TRAP in microdissected CA1 neuropil revealed 383 dendritic FMRP targets and suggests that FMRP differentially regulates functionally distinct modules in CA1 dendrites and cell bodies. FMRP regulates ~15–20% of mRNAs encoding synaptic functions and 10% of chromatin modulators, in the dendrite and cell body, respectively. In the absence of FMRP, dendritic FMRP targets had increased ribosome association, consistent with a function for FMRP in synaptic translational repression. Conversely, downregulation of FMRP targets involved in chromatin regulation in cell bodies suggests a role for FMRP in stabilizing mRNAs containing stalled ribosomes in this compartment. Together, the data support a model in which FMRP regulates the translation and expression of synaptic and nuclear proteins within different compartments of a single neuronal cell type.
Epilog
Authors: Westerlund Stina , Borg Kajsa , Porko-Hudd Mia , Lindberg Viveca
Published: December 2021

De olika bidragen i antologin grundar sig i den slöjdverksamhet som funnits i nordiska skolor sedan närmare 150 år. Hur har slöjdkunnandet förändrats? Artik­larna berör många aspekter av slöjdaktiviteter, men skall inte uppfattas som en forskningsöversikt, endast som exempel på nutida slöjdforskning. Här återfinner vi några av alla de eldsjälar som betytt oerhört mycket för slöjdämnets utveckling och konsolidering i både referenslistor och texter. De slöjdande barnens röst blir hörd, ämnets organisation och slöjdlärarnas undervisning disku­­teras. Vi påminns även om grundläggande begrepp och bildningsfrågor (no. danning) som utgör en del av basen för all slöjdundervisning oavsett vilken tidsålder vi befinner oss i.
Läs vidare i epilogen genom att klicka på "pdf" till höger om denna text.
Territorios y temporalidades de la alteridad.
Authors: Delrio Walter , Pérez Pilar
Published: December 2021

En este trabajo nos interesa abordar las construcciones estatales desde el estudio de las poblaciones originarias, especialmente haciendo foco en las transformaciones en sus relaciones transcordilleranas y en sus formas de territorialidad. Se analiza entonces su vínculo con el establecimiento de los sistemas de diferenciación llevados a la práctica por los estados nacionales. Proceso en el cual se inserta el establecimiento de un límite binacional, el acceso diferencial a los medios de producción, mecanismos de vigilancia, control y disciplinamiento, teorías de construcción social e imposiciones y construcción de identificaciones nacionales. El objetivo es analizar desde el caso argentino una triple frontera, la primera vinculada a la construcción espacio-temporal de los estados nacionales, la segunda es la frontera normativización de los cuerpos que define lugares discretos de lo indígena; y la tercera la frontera disciplinante en la nueva sociedad. Entendemos a las mismas como momentos en los cuales se produce y reproduce la alteridad y que posibilitan comprender en su dimensión histórica los condicionamientos y posibilidades de la territoriali-zación mapuche-tehuelche a partir de la incorporación forzada a los estados nacionales. Utilizamos para ello fuentes -oficiales y de la memoria social- que recuperan las experiencias de personas del común, hombres, mujeres, niñas y niños mapuche y tehuelche.
Arqueología y Patrimonio. Hacia la gestión del conocimiento arqueológico en el Lago Nahuel Huapi: avances y perspectivas en investigación y conservación
Authors: Scartascini Federico Luis , Bianchi Villelli Marcia Eliana , Vargas Fernando Emmanuel , Caracotche Maria Soledad , Fernandez Do Rio Solange , Bay Gavuzzo Alhue , Braicovich Romina , Fernandez Maria Victoria
Published: December 2021

En este artículo se presentan los resultados de un extenso trabajo interinstitucional para la conformación de la base de recursos cultural del área del Lago Nahuel Huapi y zonas de influencia (Parque Nacional Nahuel Huapi y Provincia de Río Negro, Argentina). Con el fin de aportar a la gestión del conocimiento arqueológico, se sistematizó y estandarizó una enorme cantidad de información producida, distribuida en diversos formatos y estados de procesamiento. Como resultado se recopiló la información georreferenciada de 209 sitios arqueológicos, con su respectiva información de manejo. Los análisis iniciales muestran algunas tendencias relevantes en cuanto a la producción desigual de la información entre las jurisdicciones consideradas, dificultando las tareas de protección y gestión del patrimonio. También se observó, la carencia a nivel regional de información cronológica para gran parte de los sitios considerados. En función de proponer líneas de investigación y conservación, se analizaron algunas tendencias iniciales respecto del uso humano del espacio, destacándose el rol de los sectores acuáticos como lugares centrales de ocupación y tránsito humano. Finalmente, se destaca la necesidad de avanzar en la articulación conjunta de los espacios de gestión e investigación.
Presentación del dossier
Authors: Pérez Alberto Enrique
Published: December 2021

Este Dossier está dirigido a profundizar el debate de antiguos y novedosas materialidades y aspectos inmateriales de interés arqueológico que aporten al conocimiento del pasado acerca del territorio históricamente denominado Wallmapu y sus protagonistas.
Influence of Stress on Quality of Sleep and QT Interval Variables among Young Adult Medical Students- A Cross-sectional Study
Authors: Itagi Afreen Begum H , Dharmalingam Amudharaj , Dipankar Satish , Berad Akshay , Velou Senthil M , Subramanian Senthil Kumar
Published: December 2021

Introduction: Stress affects different cardiovascular responses and trigger arrhythmias through Autonomic Nervous System (ANS) activation. Medical students generally tend to reduce their sleep, in order to adjust and cope with their stressful and demanding workload. Aim: To assess the correlation of QT intervals variables with quality of sleep and stress among young adult medical students. Materials and Methods: This cross-sectional study was undertaken in All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India, among 60 medical students taken as internal match for collection of data at the beginning of the academic year (unstressed) and three weeks before the term-end examination (stressed) during October 2019 to March 2020. Two validated questionnaires namely, Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality and the Medical Student Stress Questionnaire (MSSQ) to measure the stressors and the intensity of stress were used among the medical students. Short-term Electrocardiogram (ECG) recording was used to measure QT interval variables. Descriptive statistics and paired t-test were applied using Statistical Package for the Social Sciences (SPSS) version 19.0. The p≤0.05 was considered significant. Results: Academic Related Stress (ARS) showed a highly significant increase during the stressed conditions (p<0.001). The mean global PSQI score of 6.03±2.76 was significantly higher (p-value <0.001; PSQI >5) during the stressed conditions indicating poor quality of sleep, when compared to 4.50±2.87 recorded in unstressed conditions. In stressed conditions, QT interval measures had moderate correlation with ARS. Quality of sleep had negative correlations with all QT interval measures except for corrected QT interval (QTc) and QTCmin. Conclusion: Stress affects the sleep quality and induced QT changes which reflected difference in variability between ‘stressed’ and ‘unstressed’ times. However, there is no significant impact on QT duration among the young adult medical students.
Comparison of Body Composition Parameters in Swimmers and Non Swimmers: A Cross-sectional Study
Authors: Kizhakkevalappil Sruthi Parayil , Alexander Reena , Nhattuvalappil Arun Chandran
Published: December 2021

Introduction: Swimming is an inexpensive isotonic exercise that is useful for health promotion and prevention of disease. While studies based on body composition and swimming in India are few, the analysis of body composition parameters can provide accurate body assessment and serve as an ideal mode for fitness analysis and promotion of health. Aim: To assess the body composition, anthropometric and cardiac parameters of healthy swimmers and compare these variables with that of healthy non swimmers. Materials and Methods: A comparative cross-sectional study was conducted in the Department of Physiology, Government Medical College, Thrissur, Kerala, India. Duration of study was from January 2017 to January 2018. A total 60 healthy individuals, 30 swimmers and 30 non swimmers were selected by simple random sampling method. Body composition parameters were estimated along with anthropometric measurements and cardiac parameters- height, weight, Body Mass Index (BMI), pulse rate, systolic and diastolic blood pressure. Quantitative variables like body composition parameters were analysed using mean standard deviation and 95% confidential interval. Comparison of body composition parameters were analysed using independent t-test and significant level was kept at 5%. Results: The mean age of swimmers was 19.93±1.59 years and that of non swimmer subjects was 22.87±1.88 years. Body composition parameters included Body Fat Percentage (BFP p-value <0.001), Fat Mass (FM p-value <0.001) and Basal Metabolic Rate (BMR p-value <0.001) were found to be significantly decreased (p-value <0.05) in swimmers when compared to non swimmers. However, the Fat Free Mass (FFM p-value=0.13) and Fat Free Mass Index (FFMI p-value=0.22) were also decreased but comparable (p-value >0.05). Weight and BMI along with pulse, systolic blood pressure and diastolic blood pressure (p-value <0.001) were lower in swimmers than non swimmers and statistically significant (p-value <0.05) by independent t-test. Conclusion: The results indicated that, swimming can improve body composition parameters to a more healthy state and therefore can be advised as a form of regular physical activity with a goal to achieve ideal health and fitness.
Kumaraswamy-Janardan Distribution: A Generalized Janardan Distribution with Application to Real Data
Authors: Dzivor Nelson Doe , Otoo Henry , Wiah Eric Neebo
Published: December 2021

The quest to improve on flexibility of probability distributions motivated this research. Four-parameter Janardan generalized distribution known as Kumaraswamy-Janardan distribution is proposed through method of parameterization and studied. The probability density function, cumulative density function, survival rate function as well as hazard rate function of the distribution are established. Statistical properties such as moments, moment generating function as well as maximum likelihood of the model are discussed. The parameters are estimated using the simulated annealing optimization algorithm.   Flexibility of the model in comparison with the baseline model as well as other competing sub-models is verified using Akaike Information Criteria (AIC). The model is tested with real data and is proven to be more flexible in fitting real data than any of its sub-models considered.
Performance Comparison of OSPFV3 and EIGRP with IPv6 Network
Authors: Essah Richard , Anand Darpan
Published: December 2021

A collection of interconnected devices that deal with communication protocols that are common to share resources provided by nodes of a network over digital interconnections is a computer network. The process of determining the most efficient route from a source to a given target is called routing. Cisco's Enriched Internal Routing Gateway Protocol for IPv6 and the IETF's OSPFv3 (First Version 3 of Open Shortest Path) are two of the most frequently studied IPv6 routing protocols among researchers (EIGRPv6). As a result of the popularity of EIGRPv6 and OSPFv3, it is necessary to undertake a thorough contrast of the two protocols once working inside a minor enterprise network on IPv6. Thus, the study analysed the performance comparison of OSPFV3 and EIGRP with IPv6 networks with regards to convergence time, end-to-end delay, and packet loss. Packet Tracer 6.2.2 was used to compare the performance of routing protocols of different kinds. In the simulation, Cisco routers, switches, and generic computers were employed in the test. In these topologies, standard IPv6 addresses have been used. The findings of the study revealed that EIGRPv6 outperforms OSPFv3. As a result, we advocate using EIGRPv6 as an internal routing protocol in a network of IPv6.
Comparative Evaluation of the Amount of Sorption and Solubility Seen in Soft Liner with Herbal and Commercially Available Denture Cleanser - An In vitro Study
Authors: Sehgal Malika J. , Dubey Surekha
Published: December 2021

Aims: the aim of the current study is to assess the quantity of sorption and solubility seen in the soft denture liner with herbal (neem) and commercially (clinsodent) available denture cleanser.

Materials and Methods: The cross sectional study was carried out in the Department of Prosthodontics at Sharad Pawar Dental College And Hospital between February 2021 and July 2021. 52 samples of heat cured acrylic resin of circular shape were prepared using a stainless steel mould. The resilient liner was applied to all the samples using a denture adhesive. All samples will then be desiccated for 24 hours to get a stable or conditioned weight W1. The samples will then be divided into 2 groups namely: Group A (clinsodent group) and the Group B (herbal denture cleanser group). All the samples were immersed daily in cleanser for 8 hour and then transferred to artificial saliva for rest 16 hours of the day. Solutions of artificial saliva and denture cleanser was changed daily for the entire period of study that is 7 days. Later, all the test samples were removed from saliva, wiped dry, weighed for saturated weight W2. - After desiccating again for 24 hours the samples were again assessed for renovated weight that is W3.

Results: With respect to sorption and solubility it was found that the clinsodent group exhibited greater percentage of sorption when compared to the neem denture cleanser group after a period of 7 days, p-values of 0.0001,S.

Conclusion: It can be established that the solubility and sorption values of clinsodent group were higher when compared to the herbal denture cleanser group. Overall, neem in the form of denture cleanser performed better than clinsodent.
Dietary Habits among Undergraduate Medical Students in Tamil Nadu; A Before and After Intervention Study
Authors: Rajasekar Hanitha , Venmathi E.
Published: December 2021

Introduction: In a developing country like India, people suffer from poverty and hunger on one hand and other lifestyle related diseases on the other hand. Unhealthy lifestyle is especially common among affluent society. Non communicable diseases has a multifactorial causation and key modifiable risk factor for NCDs is obesity. Adolescent population tends to suffer from ill effects of obesity because of unhealthy eating habits and social factor like stress. This study aims to evaluate the life style pattern especially eating habits among undergraduate medical students and possible outcome of interventional program in the form of health education.

Methods: A Before and After Intervention study was conducted among 100 undergraduate medical students in a private medical college of Tamil Nadu. Universal sampling method was used to select the study participants. A structured questionnaire was used to collect data from the study participants and Mc Nemar chi-square test was used for analysis.

Results: The Percentage of students who were overweight was 23% and obese was 5%. It was estimated that 94% of the participants had habit of consuming outside food before intervention and when enquired about the frequency 13% consumed daily, 48% consumed twice or thrice per week, 28% monthly once and 11% had rare consumption of outside food. Mc Nemar test was done to compare consumption of healthy food among study participants before and after intervention and this association was found to be statistically significant.

Conclusion: This study concluded that consumption of healthy food among study participants before and after intervention improved and association was statistically significant.
Investigation of the Effectiveness of Cortexin in the Treatment of Cardiac Arrhythmias in Children
Authors: Bolgucheva Madina Borkhaevna , Barakhoeva Khadizhet Alikhanovna , Avakian Nellya Karoevna , Tutaev Iznor Musaevich , Baranova Tatiana Sergeevna , Kotieva Madina Rashidovna , Sultukhanova Khadishat Islanovna , Abdulkadyrova Milana Lemaevna , Albegova Bela Zakharovna , Gabachieva Milana Rafikovna
Published: December 2021

In this article, a new look at cardiac rhythm and conduction disorders in children is outlined. These deviations, along with congenital malformations, have taken one of the first places in the structure of cardiovascular pathologies. This is one of the most serious problems that stands at the intersection of cardiology and pediatrics. The frequency of occurrence of severe forms of arrhythmias reaches 1:5000 of the child population, and life-threatening arrhythmias – 1:7000. Treatment of cardiac arrhythmias and conduction disorders is one of the most difficult sections of clinical pediatrics. There are medicinal and non-medicinal methods. According to experimental new data, nootropics, in particular the drug Cortexin, along with cardiotrophic drugs, form the basis of neuro-metabolic therapy and correction of children's arrhythmias.
Biomaterials – Novel Advances in Nasal Medical Implants, 3D Printing Applications
Authors: Amulya T. M. , Siree K. G. , Kumar T. M. Pramod , Bharathi M. B. , Divith K. , Nihar Gorthi , Gowrav M. P.
Published: December 2021

The scope and applications of biomaterials have spread out throughout a broad spectrum. Particularly in pharmacy, biomaterials are an attractive choice because they can be modified to decrease toxicity, increase the targeting ability among many other aspects of drug delivery. Extensive studies have led to the development of many metal-based, ceramic, biocompatible and biodegradable biomaterials for medical purposes among many others. The utilization of 3D printing in this discipline is a very novel research subject with infinite potential. Personalized and customized nasal implants are a great option to increase patient compliance and 3D printed accurate anatomical structures are rendered to be effective tools of learning. One of the disadvantages of biomaterial-based implants is the formation of a thick fibrous capsule formation around the implant, others being breakage, soft tissue loss and so on. Regulatory aspects are less explored for nasal implants. 3D printing is a unique technique that allows for a high degree of customisation in pharmacy, dentistry and in designing of medical devices. Current research in 3D printing indicates towards reproducing an organ in the form of a chip; paving the way for more studies and opportunities to perfecting the existing technique.
Frovatriptan Succinate Loaded Lipid Nanoparticles: Formulation, Evaluation, Stability Study and Shelf Life Determination
Authors: Yasir Mohd , Chauhan Iti , Verma Madhu , Noorulla KM , Tura Abdurazak J. , Haji Misbahu J. , Sara UVS , Dadi Murali , Gobena Wondesen G. , Dalecha Debesa D. , Narayana Goruntla , Veerabhadrappa Kasturi Vishwanatha Setty
Published: December 2021

Aims: The aim of the research work was to prepare and optimize the Frovatriptan Succinate (FVN) loaded solid lipid nanoparticles.

Methods: SLNs were developed by solvent  emulsification diffusion technique and evaluated for particle size, PDI, zeta potential, in-vitro drug release, and finally stability study was conducted for the detection of shelf life.

Results: The optimized formulation exhibited particle size, PDI, and zeta potential 122.85±9.24 nm, 0.129 and -25.85 mV, respectively.  In-vitro drug release study exhibited  biphasic drug release pattern.  Initially (in first two hrs) the drug was release in fast manor i.e. burst release (32.36±7.28 %). It might be due to the presence of drug on the surface of SLNs. After  2 hrs of study, the release pattern became sustained up to 24 hrs. The total amount of drug release in 24 h was found to be 91.29 ± 8.26%.  Various kinetic models were applied to evaluate the release pattern of the drug form the formulation.  Higuchi model was found to be the best fitted with the R2 value of 0.9482. The release mechanism was found to be the Fickian type with the release exponent (n) value of 0.4386. Finally, stability study was conducted. The formulation was found to be the stable under the studied conditions. The shelf life of the formulation was found to be 1.77 years.

Conclusion: Finally, it could be concluded that, the SLNs are the suitable carrier for the delivery of FVN .
Pharmaceutical Effects on Placental Morphology in Women with Gestational Diabetes Mellitus
Authors: Mehmood Ansa , Tahir Sheeza , Shabbir Amina , Khalid Namra , Salman Amber , Hanif Faiza
Published: December 2021

Objective: The purpose of this study was to see how food organization and Metformin affected placental morphology in women with GDM.

Methods: 66 GDMs were registered after providing informed consent permission. 35 patients of GDM through blood sugar levels 140 mg/dl remained allocated Set B (2500-3000Kcal/day and 30-minute walk three times a week). They remained reserved on diet control, while 34 patients of GDM through blood sugar levels >140 mg/dl have been delegated Set C and remained reserved on diet with tablet Metformin (550mg TDS). Lastly, 28 healthy pregnant women remained retained in Set A as controls. Placentas were stored and analyzed for morphology after delivery.

Results: Heavy placentae thru extensive villous immature, charangoists, and syncytial knots were observed in set B, while fibrinoid necrosis and calcification were observed in set C. Placental and cord width were significant in Set B against A, but only cord width was relevant in Set C against A in gross morphology. In light microscopy, charangoists, infarction, and syncytial loops showed detected in sample 2 against with a villous maturity; moreover, charangoists and syncytial knots have been found in appendix B versus C placental width, but C versus A results were negligible.

Conclusion: In comparison to the diet group, metformin exhibited beneficial benefits on placental morphology that were equivalent to normal controls.
Imagining of Acute Respiratory Distress Syndrome: A Review
Authors: El-Kenawy Hossam A. , Aldarsouny Abdullah Thamer , Alaqel Nouf Mohammed , Alkhamis Noor Anwar S. , Aldawood Fatimah Fayez J , Alhazzani Yazeed Abdulaziz , Alnufaie Nawaf Fahad , Aledaili Sara Abdullah S , Alkhalifah Waleed Abdullah , Alharbi Amal Mohammed , Alshammari Abdulaziz Ayed , Hariri Lena Mohammednoor
Published: December 2021

Acute respiratory distress syndrome (ARDS) is a life-threatening disorder marked by low oxygen levels and rigid or non-compliant lungs. In the absence of any indication of cardiogenic pulmonary edema, ARDS is defined as an acute disease that begins within 7 days of the triggering event and is marked by bilateral lung infiltrates and severe progressive hypoxemia. ARDS has a significant death rate, and there are few effective treatment options for this life-threatening illness. The management of these severely ill patients in the intensive care unit relies heavily on imaging. Chest radiography, bedside lung ultrasonography, and computed tomography scans can all help with patient care and prognostic variables identification. However, imaging results are not always specific, and other diagnosis should be considered.
Prevalence and Management of Hypertension along with its Complications - A Prospective Study
Authors: Dinakaran Aishwarya , Chandrika R. E. M. Prema , Shareef Mohd Mubashir , Sultana Mehraj , Khanam Quarratul Ain , Rao P. Sailaja
Published: December 2021

Aim: The main aim of the study was to estimate the prevalence of hypertension and correlate hypertension with the occurrence of its complications.

Study Design: The study was designed to detect the adverse outcomes of uncontrolled hypertension and review the treatment patterns in the management of hypertension along with the complications.

Place and Duration of the Study: This study was an observational study conducted for a period of six months from January to June 2020, at THUMBAY HOSPITAL NEW LIFE, in an inpatient department.

Methodology: Using a suitable designed data form, details of the patient were collected from patient demographics, prescription charts, laboratory data, medical records, doctor's and nursing notes.

Results: In this study, the prevalence of hypertension was found to be more in males (52.5%) than in females (47.5%). Among all age groups, individuals aged 50-59 yrs were highly affected. From the study, it was found that a greater number of patients fall in the category of stage-2 hypertension (38.75%) followed by hypertension crisis (28.75%), stage-1 hypertension (25%), and normal (7.5%). More patients with uncontrolled hypertension experienced cardiovascular complications (55%) when compared to cerebrovascular (27.5%) and renal (17.5%) complications. Chi Squared Test was used to analyse the significance of the study. P values < 0.0001 was considered as statistically significant.

Conclusion: It was concluded that the choice of antihypertensive drugs used in the management of hypertension were diuretics followed by Angiotensin receptor blockers (ARBs) and Calcium Channel blockers. The most commonly prescribed drugs in the study were Furosemide, Telmisartan, Amlodipine, Metoprolol, followed by clinidipine, carvedilol, metolazone, perindopril, cardiopril, and torsemide.