bluuebunny/crossref_metadata_2025 huggingface dataset:
Antidiabetic Activity of Catechin from Cinnamon (Cinnamomun Burmanii) by Inhibiting Alfa Glucosidase Enzyme
Authors: Zaenab St , Hasyim Zohrah
Published: September 2024

Diabetes mellitus (DM) is a chronic disease that occurs when the body experiences insulin resistance. One of the treatment for DM is by inhibiting the performance of the -glucosidase enzyme which is located on the smooth wall. Indonesia is famous for having various types of herbal plants that are often used as traditional ingredients, one of which is cinnamon (Cinnamomun burman II) which has compounds such as catechins that are useful as antioxidants. This research method a docking simulation, the ligand was downloaded in the Pubmed database and the androgen receptor macromolecule was downloaded in the Protein Data Bank (PDB), the ligand structure preparation, the test ligand docking simulation and the comparison uses the pymol,pyrx program, and Lipinski test, toxicity test using the PREADMET program. The results of binding affinity for the test compound, namely catechin compounds, obtained a binding affinity of -8.0 kcal/mol, while the comparative test, metformin, obtained a binding affinity of -3.3 kcal/mol and Lipinski qualifies as non-carcinogens but can be mutagens. These results indicate that catechin compounds have greater inhibition on alpha glucosidase receptors that cause type 2 diabetes mellitus compared to metformin compounds.
The Influence of Service Quality and Trust on User Loyalty through User Satisfaction DANA in Jakarta
Authors: Sari Annisa , Usman Osly
Published: September 2024

The rapid pace of technology has produced a new innovation in financial matters, namely Financial Technology, which has also given rise to something new, namely digital transactions or e-wallets. The aim of this research is to determine the effect of service quality and trust on user loyalty through DANA user satisfaction in Jakarta. This research uses quantitative methods with a research population of 100 people and data collection techniques using questionnaires. The sampling technique used was purposive sampling. Data analysis in this research uses the help of SmartPLS 4. The results of the research are that service quality has a positive and insignificant influence on user loyalty, there is a positive and significant influence between service quality and user satisfaction, there is a positive and significant influence between trust and user loyalty, there is positive and significant influence between trust and user satisfaction, the influence between user satisfaction and user loyalty is positive and not significant, service quality through user satisfaction has a positive and not significant influence on user loyalty, and trust and user loyalty through user satisfaction is positive and not significant.
The Influence of Human Resource Development and Economic Growth on Poverty
Authors: Mustain/Nasriati Amigrah Mustain
Published: September 2024

The purpose of this study is to analyze the impact of Human Resources (HR) and economic growth on poverty in the Luwu Raya region, South Sulawesi. Despite improvements in economic growth indicators at both national and regional levels, uneven distribution of this growth often exacerbates inequality and worsens poverty conditions. This research utilizes panel data from 2011 to 2023 and employs multiple linear regression methods using EViews 10. The results indicate that HR has a significant and negative impact on poverty, where a 1% increase in HR quality reduces poverty by 7.39%. Conversely, economic growth shows a positive but not significant impact on poverty, suggesting that economic growth has not uniformly improved the welfare of the Luwu Raya population. Analysis using the Random Effect Model (REM) demonstrates that HR and economic growth together have a significant effect on reducing poverty levels. The coefficient of determination of 66.2% indicates that HR and economic growth variables can explain variations in poverty in Luwu Raya. The findings of this study are expected to assist policymakers in formulating more effective development strategies, particularly in improving HR quality to reduce poverty.
Profil Pelajar Pancasila dalam Perspektif Pendidikan Kewarganegaraan
Authors: Fadya Mardhiyyah  , Darmawan Cecep , Mahpudz Asep
Published: September 2024

ABSTRAK
Penelitian ini bertujuan untuk menganalisis profil pelajar Pancasila secara konsepsi maupun kebijakan dalam perspektif Pendidikan Kewarganegaraan di tiga sekolah menengah di Kota Bandung, yaitu SMAN 12, SMAN 23, dan SMAN 25. Tujuan dari penelitian ini adalah untuk menerapkan kebijakan profil pelajar Pancasila yang memiliki integritas dan moralitas tinggi, serta untuk meminimalisir praktik pendidikan yang berorientasi pada komersialisasi dan proseduralitas semata. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus. Melalui metode ini, peneliti dapat memperoleh pemahaman mendalam tentang kasus yang diteliti berdasarkan pengalaman dan perspektif partisipan yang terlibat secara langsung dalam penelitian. Peneliti menggunakan wawancara mendalam (in-depth interview) dengan partisipan yang dianggap sebagai pemeran utama dan memiliki pengalaman yang relevan dengan fokus penelitian ini.Kesimpulan dari penelitian ini menunjukkan bahwa profil pelajar Pancasila merupakan kebijakan penting dalam satuan pendidikan yang bersifat komprehensif. Meskipun masih terdapat beberapa kendala dalam pengembangan dimensi profil pelajar Pancasila dan perencanaan P5 (Projek Penguatan Profil Pelajar Pancasila), sekolah-sekolah yang menjadi lokasi penelitian telah berhasil menerjemahkan dan merealisasikan kebijakan tersebut.Seluruh subjek penelitian sepakat, bahwa profil pelajar Pancasila perlu diberlakukan dalam satuan pendidikan pada era ini. Namun, tetap mereka berharap, penerapan profil pelajar Pancasila dalam satuan pendidikan tidak sebatas slogan saja, tetapi bisa terus dilaksanakan dan dapat bermanfaat positif terhadap pengembangan karakter, kompetensi, dan sikap warga negara muda. Meskipun belum mengejewantahkan sila Pancasila secara utuh, namun dimensi-dimensi profil pelajar Pancasila memodifikasi nilai Pancasila dan kompetensi abad 21.
Kata kunci : kompetensi abad 21, pendidikan kewarnegaraan, profil pelajar pancasila
Pengaruh Model SQ3R Terhadap Peningkatan Pemahaman Siswa Pada Materi Komitmen Kebangsaan
Authors: Adjani Sattira , Komalasari Kokom , Halimi Muhammad
Published: September 2024

ABSTRAK
Materi Komitmen kebangsaan dalam pembelajaran PPKn  berfokus pada upaya mewujudkan cita-cita nasional dan membangun wawasan kebangsaan. Namun, banyak guru PPKn menghadapi tantangan dalam menyampaikan materi dengan efektif. Salah satu permasalahan umum adalah penggunaan model pembelajaran konvensional yang hanya mengedepankan penjelasan satu arah tanpa adanya interaksi dengan siswa, menyebabkan keterlibatan siswa yang rendah dan pemahaman yang terbatas. Dalam penelitian ini, peneliti menyarankan penggunaan model pembelajaran SQ3R (Survey, Question, Read, Recite, Review) sebagai solusi untuk mengatasi masalah tersebut. Dengan metode kuasi-eksperimen dan pendekatan kuantitatif, peneliti menjelaskan pengaruh signifikan dari model pembelajaran SQ3R terhadap peningkatan pemahaman siswa pada materi komitmen kebangsaan. Hasil analisis menunjukkan perbedaan yang signifikan antara kelompok siswa yang menerapkan model SQ3R (kelompok eksperimen) dan kelompok yang tidak (kelompok kontrol), dengan nilai thitung > ttabel (2,743 > 1,678) dan taraf signifikansi 0,08 > 0,05
Kata kunci : komitmen kebangsaan, model pembelajaran SQ3R, pemahaman siswa
atuação dos enfermeiros nos Institutos Federais de Ciência e Tecnologia e sua contribuição para a educação integral.
Authors: Amadei Juliana , Peres Zago de Oliveira Fátima , Leandro Plácido Reginaldo , Aparecido de Carvalho Eder , Fernandes Denise
Published: September 2024

O artigo apresenta a percepção dos enfermeiros atuantes na educação profissional e tecnológica (EPT), quanto à sua contribuição na educação integral de alunos dos cursos técnicos integrados ao Ensino Médio. Os dados foram coletados através de entrevista semiestruturada a enfermeiros de diferentes campi de um Instituto Federal e analisados pela Análise de Conteúdo. Os resultados foram dispostos em três categorias: I- Atuação do enfermeiro no  ambiente escolar: relata a percepção dos enfermeiros quanto às atividades no ambiente escolar em um sistema de ensino que visa à formação integral. II- Sistematização da assistência de enfermagem no ambiente escolar: apresenta a percepção dos enfermeiros sobre as formas de registros dos atendimentos de enfermagem e sua importância no contexto escolar na contribuição para a educação integral. III- Contribuições do enfermeiro escolar na educação integral: identifica as percepções dos enfermeiros quanto aos conceitos de educação integral, formação omnilateral e o entendimento do que é a EPT proposta pelos Institutos Federais. Nossas observações nos levam a concluir que os enfermeiros têm compreensão da proposta da educação integral e da formação omnilateral, contribuem e compreendem que contribuem com a educação integral, além de sentirem-se como educadores atuando no ambiente escolar. Ademais, identificamos que a atuação do enfermeiro com os educandos possibilita uma melhoria na qualidade de vida, facilita o acesso aos serviços da rede de atendimento, principalmente para os estudantes em situação de vulnerabilidade, e consequentemente contribui para o ensino, a aprendizagem, a permanência e o êxito escolar.
Association Between substance addiction and cortical changes in Adults：A Mendelian Randomization Study
Authors: Zhang Zidong , Wang Zhen , Zou Jing , Zhang Le , Ning Jinghua , Zhang Xin , Heng Liu , Zhang Chenggui , Liang Yi , Zhang Yuzhe
Published: September 2024

This study employs Mendelian randomization (MR) to investigate the causal relationship between substance addiction (including alcohol, cannabis, painkillers, sedatives, sleeping pills, and smoking) and cortical changes. Data on substance addiction were sourced from the Psychiatric Genomics Consortium (PGC) and the UK Biobank. Cortical data from the Enigma Consortium were used to examine the relationship between substance addiction and changes in cortical structure. At the regional brain level, addiction may affect the thickness (TH) of bankssts, cuneus, superior temporal, pars triangularis, middle temporal, insula, fusiform, and lingual regions, as well as the surface area (SA) of precentral, postcentral, lateral occipital, inferior parietal, inferior temporal, posterior cingulate, frontal pole, caudal anterior cingulate, pericalcarine, pars triangularis, temporal pole, and lingual regions. The findings suggest that substance use disorders may significantly impact the insula, pars triangularis, and particularly the inferior temporal regions of the brain. This provides new insights into the effects of addictive substances on the cerebral cortex and offers further evidence for the diagnosis of substance use disorders. Additionally, this study may suggest new avenues for treatment in individuals with substance use disorders.
Total Body Potassium, Body Cell Mass, and Their Relation to Frailty and Bedside Tools: A Pilot Study in Adults with Cirrhosis
Authors: Tandon Puneeta , Limon-Miro Ana , Sekulic Karolina , Isley Serena , Prado Carla
Published: September 2024

Accurately assessing body composition in cirrhosis is challenging as fluid shifts affect most techniques. The whole-body counter is a state-of-the-art method that measures total body potassium (TBK) unbiased by fluid, from which body cell mass (BCM) is derived. This pilot study in 20 patients with cirrhosis characterized TBK and BCM, and explored their association with frailty; evaluated BCM relationship with the liver frailty index (LFI), bioimpedance analysis-based phase angle, calf circumference (CC), and BMI (body mass index)/edema-adjusted CC. Stepwise multiple linear regression analysis and Pearson’s correlation tests were conducted. Adjusted for sex, BCM and TBK were inversely associated with frailty (p<0.0001). LFI r=-0.568 (p=0.009), CC r=0.484 (p=0.031), and edema-adjusted CC r=0.467 (p=0.038), demonstrated moderate correlations with BCM. Further research involving a larger sample of participants with cirrhosis is needed to confirm these findings and enhance our understanding of the association between these advanced body composition measures and frailty.
Assessing the Role of Straw Checkerboard Barriers and Plants in Soil Health and Microbial Activity
Authors: Zhu Zhihao , Qu Jianjun , Meng Chen
Published: September 2024

[Aims] As a new type of sand barrier, the construction efficiency and service life of brush straw checkerboard barrier are better than traditional artificial straw checkerboard barrier, the aim of this work were to understand the effect of its combination with plants on soil function recovery.
[Methods] This study was conducted in the southeastern edge of the Tengger Desert, Zhongwei, Ningxia. Seven different sand barrier and plant combinations were selected as experimental subjects, with bare sandy land serving as the control group. The investigation included assessments of soil physical and chemical properties and microbial characteristics.
[Results] Results showed the beneficial effect of installing straw checkerboard barriers on enhancing soil moisture levels, with planted variants having lower water content compared to unplanted counterparts. Obviously, Artemisia desertorum, Caragana korshinskii, Corethrodendron scoparium, and Calligonum mongolicum showed a pronounced dependence on soil moisture within the 0 ~ 10 cm soil layer. Improvements in soil organic matter, total nitrogen, and electrical conductivity were observed following the implementation of sand control measures, with the combined application of artificial straw checkerboard barriers and Calligonum mongolicum providing optimal results. Furthermore, the Artemisia desertorum mode promoted increased soil bacterial abundance, while the brush straw checkerboard barrier along with Corethrodendron scoparium contributed to increased soil fungal populations.
[Conclusion] Different combinations of straw checkerboard barrier and plant can promote different soil physical and chemical properties and microbial characteristics. These findings can provide relevant scientific evidence and references for selecting sand control measures.
Nomophobia among Nurses in Northeast of Iran: A Cross Sectional Study
Authors: kashani Leila , Azizi Mohammad Mehdi , shahini najmeh , Rajabi Abdolhalim , Nejad Amir Maghsoudloo
Published: September 2024

Introduction:
The role of cell phones becomes more prominent every day; however, excessive use leads to high dependency. Nomophobia is a type of phobia in which the patient experiences severe anxiety and worry while away from a mobile phone. The present study aimed to investigate the prevalence of Nomophobia in nurses of Educational-Medical Hospitals in Gorgan city in 2022.
Materials and Methods
In a cross-sectional, 412 nurses of educational and medical hospitals in Gorgan city, Iran, 2022 were enrolled. A demographic information checklist, and Nomophobia questionnaire were used to collect data. Statistical analysis was performed using SPSS software version 18.
Results
Most nurses were moderate Nomophobia (55.1%). There was a significant relationship between Nomophobia and age, marital status, number of active social messaging software, duration of mobile phone use, and the number of phone checking per day. Such findings were also observed for subscales, including lack of access to information, loss of comfort and convenience, inability to communicate, and loss of connection with some considered features.
Conclusion
The present study showed a high frequency of Nomophobia and cell phone dependence in nurses of Gorgan Educational-Medical Hospitals in Gorgan city. Young people, single people, who spend more time on mobile phones, have more social messaging software and check their cell phones more often are more likely to have Nomophobia.
Precipitation and Pan Evaporation Patterns in YHH Basin (1950-2023): Analysis and Influencing Factors
Authors: Wang Shengfeng , Xu Xinmiao , Lei Longwei
Published: September 2024

Considering the vital importance of the Yellow River-Huai River-Haihe River (YHH) basin in national food security and water resource management, a thorough investigation into the spatiotemporal distribution of precipitation and pan evaporation, along with the factors that influence these phenomena, is essential for the region's agricultural productivity, economic growth, and cultural sustainability. To this end, daily meteorological data from 159 stations across the YHH basin from 1950 to 2023 were hereby utilized for exploration. Advanced methods such as Kriging spatial interpolation, regression analysis, Mann-Kendall trend analysis, and wavelet analysis were employed to elucidate the spatial distribution, interannual variability, and periodicity of precipitation and evaporation. Furthermore, Pearson correlation analysis was conducted to examine the inter relationships among various meteorological elements, while a multi-year monthly mean model was used to analyze the monthly variation patterns of regional precipitation and evaporation within a year. Moreover, the center of the gravity migration model was introduced to reveal the spatiotemporal evolution patterns of these meteorological elements. Overall, this research breaks new ground by examining the seasonal dynamics between precipitation and pan evaporation in the YHH basin and their implications for agricultural irrigation. The insights gained provide vital scientific backing for developing regional land management strategies, guiding crop cultivation plans, and fostering agricultural resilience in the face of climate change.
The astragalar dorsal foramen and the astragalar flexor groove in Felidae and Coypus
Authors: Lorente Malena
Published: September 2024

The dorsal foramen and the flexor groove are traditionally considered traits of plantigrade and pentadactyl mammals, and therefore basal unspecialized taxa, and they are often cited as a features that would have limited plantar flexion of the foot. Blood vessels, nerves, ligaments and tendons have been proposed passing through the foramen. During the last two years I had the opportunity to dissect three roadkills: a Myocastor coypus, a Felis catus and a Leopardus geoffroyi. I found the distinct presence of the upper joint capsule border before the end of the trochlea in the three animals. The limit of the trochlea being marked by the posterior edges of the lateral and medial malleolar facets. The astragalar foramen was present in both felids. Through the dorsal foramen was a unidentified blood vessel. No nerves or ligaments were found passing through the foramen. The flexor digitorum longus muscle of L. geoffroyi had a sesamoid at the height of the tibioastragalar articulation. Although these are considered traits of plantigrade and pentadactyl mammals, they are common in Carnivora, particularly common in felids, being observed at least in the genera Felis, Leopardus, Panthera, Prionailurus, Puma, and Smilodon.
Current Practices and Perceptions of Indocyanine Green Fluorescence Guided Liver Surgery: Insights from a Survey of Hepato-pancreato-biliary Surgeons in the United Kingdom
Authors: Karmarkar Rahi , Latour Jos , Hosking Joanne , Aroori Somaiah
Published: September 2024

Background:
Indocyanine Green (ICG) fluorescence-guided surgery (I-FIGS) is increasingly being used in hepato-pancreatico-biliary (HPB) surgery. However, the true benefit of I-FIGS, the optimum dosing, and the timing of ICG administration still need to be determined. To conduct future research studies in the above areas, it is essential to understand the current I-FIGS practices among surgeons. This survey investigated the practices and perceptions of I-FIGS in liver surgery among HPB surgeons in the United Kingdom (UK).
Methodology:
A survey was sent via email and social media to surgeons from all HPB units in the UK. The survey consisted of 18 questions, covering various aspects such as experience levels, volume of operations, approach to liver resections, ICG dosage, timing of administration, application specifics, camera systems used, and willingness to participate in future trials.
Results:
The survey was sent to 81 HPB surgeons (working in 25 HPB units) across the UK. The response rate was 70% (57/81 surgeons). Fifty-six percent of the surgeons reported having the infrastructure for I-FIGS at their hospital. The use of I-FIGS varied in duration and patient volume, with 47% of surgeons reporting its use for less than one year and 53% of surgeons reporting using it in fewer than ten patients. Preferences for the dose and timing of ICG administration also varied, reflecting the absence of standardised guidelines. The Storz camera system emerged as the most used imaging system (42% of surgeons), followed by the Stryker (25.8%). None of the surgeons reported any I-FIGS-related side effects. Ninety-six per cent of surgeons expressed interest in participating in future clinical trials in the field of I-FIGS.
Conclusion:
The survey highlights that I-FIGS in liver surgery is not widely used in the UK. There are also wide variations in the dosing and timing of ICG administration. Large multi-centre studies are needed to focus on dosing, timing of ICG administration, and establishing its actual role in liver surgery.
Study on Secondary Collapse of the Bottom Frame Masonry Structure in Semi- ruined State based on FEM-FDEM
Authors: Xu Defeng , Sun Feifei , Zhao Huaixiang , Qi Honghui , Chen Limei , Hu Tianyu
Published: September 2024

The bottom frame masonry structure (BFMS) in a semi-ruined state is vulnerable to secondary collapse under strong aftershocks, posing a significant risk to rescuers during post-earthquake operations. Therefore, investigating the mechanisms and characteristics of secondary collapse of BFMS in a semi-ruined state (BFMS-SR) under aftershocks is critical. This paper proposes a numerical modeling framework for BFMS under mainshock-aftershock conditions, utilizing a combination of the finite element method (FEM) and the finite discrete element method (FDEM). The validation demonstrates that FEM-FDEM can effectively reproduce the transition of BFMS from an intact state to a semi-ruined state, ultimately leading to a secondary collapse state. Subsequently, the mechanisms and structural response characteristics of BFMS-SR under aftershocks are analyzed. The secondary collapse of the BFMS-SR under aftershocks is primarily governed by column hinge development. Furthermore, according to the time-history curve of absolute vertical velocity (AAVV), the secondary collapse of BFMS-SR exhibits four distinct stages: stabilization, structural response development, secondary collapse, and post-collapse. The end of the stabilization phase is proposed as the early-warning threshold for secondary collapse of BFMS-SR under aftershocks, aiding in post-earthquake rescue operations.
Light polarization modulation based 3D display with transparent depth visual cues
Authors: Sheng Xuemin , Lv Guojiao , Zhao Baichuan , Deng Hui , Lai Liping , Yang Mingzhong , Zhou Jiahui
Published: September 2024

In conventional three-dimensional (3D) displays, the display apparatus remains visible during the observation of 3D images. This characteristic indicates to viewers that the 3D images are generated by the display apparatus rather than being perceived as authentic, thereby hindering a truly immersive visual experience and resulting in a significantly restricted sense of immersion. Consequently, a 3D display based on light polarization modulation with transparent depth visual cues is proposed. The proposed 3D display comprises a two-dimensional (2D) display panel, a lenticular lens, a linear polarizer, a \(\:\lambda\:/4\) waveplate, a transflective mirror, and an analyzer. The linear polarizer transforms natural light from parallax images into linear polarized light. The \(\:\lambda\:/4\) waveplate introduces phase modulation to the linear polarized light. The transflective mirror alters the trajectory of the polarized light to generate a parallax image in a direction orthogonal to the 2D display panel. The light that has not undergone optical path conversion cannot pass through the analyzer, preventing the observer from perceiving the display. The transparent display structure enhances the stereoscopic display effect. By using depth vision clues and a transparent enhanced stereoscopic display structure, it is possible to achieve spatial stereoscopic display. The experimental results align closely with theoretical predictions.
Effect of precursor structure mediated by phthalic acid on the structure and properties of CN
Authors: Li Xianhua , Yu Qingbo
Published: September 2024

The dicyanodiamine/phthalic acid (DCDA/PA) precursor with molecular assembly strategy was prepared by hydrothermal treatment the mixture of dicyandiamine and phthalic acid, in which some of the amines were bound by phthalic acid through hydrogen bonding interactions, and the carbon nitride (CN) photocatalyst was further prepared by thermal polymerization. The results showed that the new chemical structure formed by the interaction of melamine cyanurate and phthalic acid through hydrogen bonding could hinder the intermolecular collision chances during the calcination process of DCDA/PA precursor, which made the polymerization reaction difficult to be carried out, and the CN photocatalysts with irregular layered stacking structure were formed. In addition, the presence of more amino groups in the CN-0.3 structure can effectively improve the separation efficiency of its photogenerated charge carriers, and after simulated visible light irradiation for 60 min, the photocatalytic activity presented by CN-0.3 for MB was 2.72 times higher than that of pristine g-C3N4.
Intra-ovarian platelet-rich plasma administration plus successive accumulated embryo transfer could be a promising strategy for poor ovarian response management: a before-after study
Authors: Zhao Hongcui , Wu Juan , Xu Yang , Shen Xiaofang , Wang Huanhuan , Zhao Aihua , Cao Fumin , Chen Xinna
Published: September 2024

Background: The management of poor responders is a significant challenge for both patients and clinicians. The aim of this study was to evaluate the effectiveness of intra-ovarian injection of Platelet-Rich Plasma (PRP) combined with successive accumulated embryo transfer in improving the outcomes of patients with Poor Ovarian Response(POR) based on POSEIDON criteria.
Methods: This single-center, retrospective before-after study was conducted at a private reproductive center, involving 49 women diagnosed with POR, indicated by an AMH level of less than 1.2 ng/ml. The participants, comprising 13 group 3 and 36 group 4 POR patients, underwent intra-ovarian injections of PRP followed by the accumulation of embryos over three successive cycles of mild stimulation IVF/ICSI from May 2021 to May 2022, before proceeding to the embryo transfer phase. The ovarian reserve markers, Oocyte and embryologic outcomes were compared in all patients before and after intra-ovarian injection of PRP. The cumulative clinical pregnancy and cumulative live birth outcomes were presented. Statistical analyses were performed using SPSS version 25. A p-value < 0.05 denoted statistical significance.
Result(s): The mean age of all participants was 37.67±4.15 years and their mean body mass index was 21.52±2.80 kg/m2. Autologous intraovarian PRP therapy significantly increased AMH levels, AFC and decreased FSH levels. Autologous intraovarian PRP therapy accompanied with 3 successive cumulated cycles, significantly increased No. of accumulated embryos and blastocysts. This strategy also significantly reduced the rate of cancelled cycle. Following this strategy, of 44 cases with accumulated embryos/blastocysts transfer, 20 (45.45%) achieved clinical pregnancy, of which 15 (34.09%) resulted in live births and 5 (11.36%) ended in miscarriage.
Conclusion(s): Intra-ovarian injection of PRP plus successive embryo accumulation following mild stimulation and accumulated embryo transfer appears to be an optimal strategy for POR management.
BMSCs Combined with Grafted igament Promote ACL Healing by Regulating NF-kB Signaling Pathway The mechanism of action of the combination
Authors: Yu Zhibin , Zhang Yuhao , Zhang Jun , Wang Chaoran , Zhao Daohong , Shen Changhui , Li Yuqi , Wan Yushan
Published: September 2024

Anterior cruciate ligament (ACL) injury is one of the most common knee injuries, and there is still no agreement on the mechanism of graft healing after ligament reconstruction. In this study, a rat model of bilateral anterior cruciate ligament (ACL) injury was established, and a series of in vitro and in vivo biological and cytological methods were used to explore the mechanism of NF-kb signaling pathway regulated by BMSCs combined with transplanted ligament in the healing of ACL reconstruction ligament. Research shows that BMSCs and co cultured damaged ligament models reduce collagen fibers and inflammation; Transcriptome sequencing revealed Ptgs2, Birc3, Icam1, Tnfrsf1a, and IL-1 β The expression of factors may be regulated by BMSCs and participate in anterior cruciate ligament injury. Further validation through Western Blot, RT qPCR, and immunohistochemistry revealed that bilateral anterior cruciate ligament injury implanted with transplanted tendon reconstruction can significantly increase TNF- α、 IL-1 β、 NF- ĸ The expression levels of B and Ptgs2 can be reduced by BMSCs treatment. Regulating NF- κB The important role of the B signaling pathway in anterior cruciate ligament healing; Prove that the combination of bone marrow mesenchymal stem cells screened in vitro and xenograft ligaments can effectively promote anterior cruciate ligament healing in a rat model (animal model).
Quantitative structure-activity relationship model to predict the stability constant of Uranium coordination complexes for novel uranium adsorbent design
Authors: Shin Hyun Kil , Sihn Youngho
Published: September 2024

A quantitative structure-activity relationship (QSAR) model for predicting the stability constant of uranium coordination complexes to accelerate the discovery of novel uranium adsorbents was developed and evaluated. Effective uranium adsorbents are crucial for mitigating environmental and health risks associated with uranium wastewater, an unavoidable byproduct of nuclear fuel production and power generation, as well as for sequestering uranium from seawater. QSAR modeling addresses the limitations of quantum mechanics calculations and offers a time- and cost-efficient computational approach for exploring vast chemical spaces. The QSAR model was built using a dataset of 108 uranium complexes, incorporating features such as physicochemical properties, coordination numbers of ligands, molecular charge, and the number of water molecules. Nineteen machine learning (ML) strategies were tested, and extreme gradient boosting (XGBoost) emerged as the best-performing ML algorithm, achieving an R² of 0.91 on the external test set after hyperparameter optimization. Including composition features significantly improved model performance, reflecting the physical factors influencing complex stability. Applicability domain analysis was conducted to evaluate model predictive performance. The QSAR model predicts stability constants from the molecular composition alone and is a valuable tool for the efficient design of safer and more sustainable uranium adsorption materials, potentially improving uranium collection processes.
Research on the Coupling Control Mechanism of ‘Yielding-Bolt-Grouting’ in Deep Water-enriched Roadway and Its Engineering Application
Authors: Zhang Jihua , Rui Qiao , Wang Lianguo , Yang Yushun , Chen Jiarui , Shen Wei , Wang Chengwu , Liu Weili
Published: September 2024

Groundwater seepage can easily cause large deformation and fracture instability of the surrounding rock in deep roadways, and the coupling support of " yield-bolt-grouting " can effectively control the occurrence of such accidents. This paper takes the specific engineering geological conditions of deep water-enriched roadway as the research background, revealing the coupling control mechanism of yield-bolt-grouting. The mechanical characteristics of the yielding tube were determined using lab analysis, and an investigation was conducted for the support control mechanism of high-strength yielding bolts. The control mechanism of grouting reinforcement is summarized, and a comprehensive coupling control technology system of yield-bolt-grouting is proposed based on the rheological large deformation characteristics of the surrounding rock of deep water-enriched roadway, with high-strength yielding grouting anchor bolts and grouting anchor cables as the core. The on-site monitoring results indicate that this technology effectively controls the deformation of the surrounding rock. The research results provide new ideas and technical approaches for controlling the surrounding rock of deep water-enriched roadways.
Macroinvertebrate distribution in relation to water and habitat quality changes in lake kuriftu,ethiopia
Authors: Lemma Rahel , Mengistou Seyoum
Published: September 2024

This study aimed at determining whether habitat or other environmental factors were critical to gauge the ecological condition and macroinvertebrate structure of a shallow lake exposed to human pressures. The fieldwork was conducted in 2023 during the dry season. The lakeshore was divided into six equal-distance sample sites. The habplot quality assessment (HabQA), which is based on Lake Habitat Quality Assessment (LHQA) method, was used to study the hydromorphological characteristics. In the littoral zone, physicochemical data were gathered using measuring probes and standard sampling procedures. Thus, a total of fifteen taxa were identified and categorized as follows: Odonata (Calopterygidae,Coenagrionidae ,Aeshnidae ,Cordulidae) ,Hemiptera (Corixidae ,Belostomatidae ,Gerridae ,Naucoridae ,Notonoctidae) ,Ephemeroptera (Baetidae ,Caenidae) and Diptera (Chironomidae ,Ceratopogenidae).Using Bray Curtis UPGMA analysis, the sample sites were grouped according to the distributions of benthic macroinvertebrates. The sites that were most similar to one another were 5 and 6, according to the UPGMA analysis. Sites 3 and 4 were found to be the sites that were the second most similar to one another. The intricacy of these sites' habitats and their littoral substrate provide an explanation for this phenomenon. TP, water temperature, and HabQA score were shown to be important contributors to the variance observed in the macroinvertebrate data. In contrast to other physicochemical factors; this study elucidated the larger significance of habitat quality parameters on the abundance of macroinvertebrate communities. For a better understanding of the different attributes crucial to macroinvertebrate abundance, we highly advise use of the HabQA scoring technique for examining the structure of macroinvertebrate communities. Management efforts should also assess different shoreline changes and give priority to preserving the littoral zone's morphological variety.
Case report and literature study on the resolution of Neonatal Mycoplasma hominis meningitis with non-specific therapy
Authors: Zhang Xiaoling , Li Fan , Wu Meigui , Wang Ling , Chen Juncao , Wang Ping
Published: September 2024

Background
Mycoplasma hominis primarily inhabits in the human urogenital tract. Pregnant women can transmit it to their newborns during delivery, posing potential risks to both full-term and preterm infants. In severe cases, it can even cause neonatal Mycoplasma hominis meningitis.
Case presentation:
We reported a case of Mycoplasma hominis meningitis in a premature infant. Azithromycin treatment was administered due to a positive amniotic fluid culture for Mycoplasma hominis. On the 13th day after birth, the infant exhibited tachycardia and decreased blood pressure, and was assisted with invasive ventilation. After blood and cerebrospinal fluid (CSF) cultures were sent for examination, meropenem and vancomycin were administered for anti-infection treatment. CSF analysis revealed a predominance of polynuclear leukocytes, and no bacterial growth was found in blood and CSF cultures. The infant was transferred to our hospital on the same day with fever, and was treated with meropenem, vancomycin, and azithromycin. After three days of hospitalization, the infant's body temperature returned to normal, and vancomycin was discontinued. The infant's clinical symptoms gradually improved, and the number of white blood cells in the CSF gradually decreased. On the 19th day, the infant had frequent episodes of apnea, and high-throughput sequencing of pathogenic microbial nucleic acid in CSF detected Mycoplasma hominis. On the 20th day, meropenem was discontinued, and azithromycin was continued for a total of 21 day. The infant was discharged in good condition, with no obvious neurological complications or sequelae.
Conclusions
We report a case of Mycoplasma hominis meningitis in a premature infant that was successfully treated with azithromycin. A review of the literature revealed that Mycoplasma hominis meningitis in neonates may have a favorable prognosis with non-specific treatment under certain conditions.
Symmetric multiple-image encryption algorithm using Chen's Hyper-Chaotic System
Authors: Cheng Dongsheng , Chen Yucheng , Huang Huiqing
Published: September 2024

In the era of big data, vast amounts of digital images are transmitted over the Internet. To safeguard the confidentiality of these images, this paper proposes a multiple image encryption algorithm (MIEA) based on 3D non-equilateral Arnold transformation (3D-NEAT) and a chaotic system, capable of encrypting any number of images simultaneously. First, the K plaintext images are superimposed to form a plaintext cube image. Next, 3D-NEAT is applied to scramble the 3D cube plaintext image at the bit level. Finally, chaotic sequences generated by Chen’s hyper-chaotic system (CHCS) are used to further confuse and diffuse the scrambled 3D cube image, resulting in a 3D cube encrypted image. Experimental simulations and security analyses demonstrate that the 3D ciphertext image produced by the proposed algorithm can withstand various security and statistical analyses and shows strong robustness against occlusion and noise attacks. These results indicate that the algorithm is both secure and efficient, making it suitable for practical applications.
Mathematics Subject Classi cation (2020) MSC code1 · MSC code2 · more
An Easy and Low-Cost Preparation of Graphene-Metal Oxide Anchored Hydrolyzed Cellulose Photocatalytic Composites for Degradation of Dye in Waste Waters
Authors: Gumus Huseyin , Buyukkidan Bulent
Published: September 2024

In this study, graphene-metal oxide photocatalyst (G-Mox) was prepared in a low-cost single step carbonization process for an alternative solution to water scarcity. Photocatalytic polymeric composites were obtained according to the nonsolvent induced phase separation technique. Photocatalyst was mixed with the hydrolyzed cellulose (prepared from textile waste)-PVDF in dimethyl formamide solution. Physicochemical and structural properties of powder and composites were characterized by X ray diffractometer, scanning electron microscope and Fourier transform infrared spectroscopy analysis. Photoluminescence analysis and contact angle measurements of photocatalyst were carried out. The photocatalytic properties of the synthesized composites were evaluated in batch and filtration system using the methyl orange (MO) as a model pollutant. The highest decolorization percentage was obtained as 91.8%. Kinetic studies revealed that Phc-30 composite showed the highest removal capacity at equilibrium with Qe:383 among the prepared catalysts. The flux and rejection% of Phc-20 at filtration cell were calculated as 42 L.m− 2.h− 1.bar − 1 and 73% respectively. The Phc composites were found to be highly reusable and suitable as membrane materials with considerable dye removal performance and easy applicability.
A complete S-shaped feedrate scheduling algorithm with variable acceleration limits
Authors: HE YUEBANG , WANG TIANLEI , WANG RUICHAO
Published: September 2024

The conventional S-shaped feedrate scheduling method requires zero starting and ending acceleration to achieve smooth acceleration, which may result in frequent acceleration oscillations in CNC machines, particularly when processing G codes with numerous short length segments. To address this problem, we propose a novel S-shaped algorithm that allows for non-zero starting and ending acceleration, while also accounting for maximum acceleration and maximum velocity constraints. By incorporating this approach along with a bidirectional scanning strategy across all segments, we effectively group them into larger blocks suitable for planning the acceleration from 0 to 0. Subsequently, within each block, a bisection search algorithm is employed to determine the maximum velocity, thereby optimizing the scheduling process. This methodology offers enhanced flexibility by considering varying acceleration limits as well as starting and ending point accelerations across segments within a block, making it more applicable to practical scenarios compared to traditional methods. Simulation and experimental results further validate the effectiveness of our algorithm in reducing machining time without compromising accuracy.
Extraction of bioactive compounds and silver nanoparticle synthesis from fruits of Rauvolfia tetraphylla
Authors: Krishnasamy Loganathan , Bharadwaj Aditya Mohan , Saravanan Govindasamy Kuppusamy , Thomas Sheena Mariam
Published: September 2024

Plant-derived bioactive chemicals have natural pharmacological effects. Rauvolfia tetrapylla has been used in the ancient days to cure a variety of ailments, including snake bites. The aim of the study is to scrutinize the bioactive chemicals isolated from Rauvolfia tetrapylla fruits in order to determine their antibacterial properties and to synthesis silver nanoparticles from the fruit extract. After 72 hours of incubation, a methanolic extract of the fruit was produced. Methanolic extract of the fruit synthesized silver nanoparticles. The fruit extract exhibited antibacterial activity against S. typhi and S. dysentriae. According to GC-MS report, there are 14 different chemicals identified in the fruit extract.
Molecular prevalence of Hepatozoon ophisauri and Toxoplasma gondii in the blood samples of wild lizards collected from various altitudes in Khyber Pakhtunkhwa, Pakistan
Authors: Ghafar Sidra , Khan Asmat Ullah , Khalid Mustansar , Haq Sami Ul , Ullah Saeed , Basit Umaima , Muqaddas Hira , Mohammed Ibrahim Abbas , Mahdi Ayat Ammar , Khan Adil , Iqbal Furhan
Published: September 2024

Despite of having rich reptilian fauna, the wild Pakistani lizards remained unexplored for the blood borne parasites. Hence, this study was designed to report the molecular prevalence and phylogenetic evaluation of Hepatozoon ophisauriand Toxoplasma gondii in blood samples of wild lizards (N = 101) that were trapped from various areas having different altitudes (ranging between 1200 to 2250 m above sea level) in Khyber Pakhtunkhwa province in Pakistan during March 2022 till June 2023. Molecular studies revealed that 3 out of 101 (03%) lizards were Hepatozoon spp. infected. All infected lizards were Laudakia (L.) tuberculata. Forty five out of one hundred and one lizards (45%) were positive for the presence of Toxoplasma gondii and infected lizards included L. agrorensis, L. pakistanica, L. tuberculate and Abblepharus (A.) pannonicus. DNA sequencing and BLAST analysis confirmed the presence of Hepatozoon ophisauri and Toxoplasma gondii. Phylogenetic analysis of both pathogens showed genetic diversity among the Pakistani isolates as they clustered with isolates reported from reptiles, birds and ticks reported from worldwide countries. Risk factor analysis revealed that prevalence of Toxoplasma gondii varied between the screened lizard species. Highest parasite prevalence was observed in L. agrorensis (67%) and A. pannonicus (67%) followed by L. pakistanica (45%) and L. tuberculate (43%). All other studies risk factors varied non significantly with the prevalence of each parasite. In conclusion, this is the first study from Pakistan reporting a a very high Toxoplasma gondii while low Hepatozoon ophisauri prevalence in Pakistani lizards. We recommended that similar and large-scale studies must be conducted in various geo-climatic regions of Pakistan that are unexplored for the prevalence of these pathogens among the wild lizards as well as in other wildlife to broaden our knowledge about their genetic diversity, host-parasite interactions and effective control.
Association between exposure to particulate matter and heart rate variability in vulnerable and susceptible individuals: Application of the Bayesian kernel machine regression model
Authors: Jeong Yong Whi , Choi Hayon Michelle , Park Youhyun , Lee Yongjin , Jung Ji Ye , Kang Dae Ryong
Published: September 2024

Particulate matter (PM) has various health effects, and individuals are simultaneously exposed to these factors. Vulnerable and susceptible individuals are more sensitive to environmental factors than nonvulnerable individuals. Exposure to PM causes cardiovascular diseases. Heart rate variability (HRV) is a biomarker that may be used to identify cardiovascular diseases, and sensitive monitoring of HRV is required. Most previous studies have evaluated exposure using environmental pollution monitoring devices located in various districts. There is a lack of research exploring the relationship between environmental pollutant exposure in personal living spaces and HRV using both indoor and outdoor measurement devices. This study aimed to investigate the association between exposure to PM and HRV using a model capable of multi-substance analysis in short-term exposures, in vulnerable and susceptible individuals, including patients with environmental disease (patients with arrhythmia, chronic airway disease, and stroke patients) and vulnerable populations (residents of an industrial complex area, the elderly). We measured PM1.0, PM2.5, PM10, and digital biomarkers in 97 participants. We evaluated the impact of short-term PM exposure on 24-h HRV over five days by measuring indoor and outdoor exposure using personalized monitoring equipment and ECG monitoring via wearable devices. The PM was calculated as a daily cumulative value and divided into days with high and low cumulative concentrations. The association between exposure to single particulate and complex mixtures and HRV was compared using multiple linear regression and Bayesian kernel machine regression (BKMR). This study found that HRV showed a negative trend with increased PM exposure on days with high cumulative PM concentrations, with statistically significant associations observed between higher PM concentrations and decreased HRV on days with high exposure. The subgroup analysis revealed that patients with chronic airway disease and residents of industrial complex areas exhibited stronger negative correlations between exposure to PM and HRV. These associations were more pronounced with complex exposure to PM1.0, PM2.5, and PM10. In short-term exposure, it was confirmed that exposure to single and complex PM is negatively associated with HRV, and this relationship varies depending on the sensitive characteristics of individuals. Integrating indoor and outdoor personalized exposure assessments with 24-hour ECG monitoring has reinforced our understanding of the complex interactions between PM and health. Our findings indicate that even 'acceptable' PM levels can harm HRV, suggesting that current thresholds may not adequately protect sensitive individuals. This highlights the need for more stringent, particle size-specific standards for at-risk groups.