bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDY OF PHYSICO-CHEMICAL PARAMETERS OF TWO PONDS IN DARBHANGA DISTRICT OF BIHAR
Authors: Dr. Ashok Kumar Singh
Published: October 2024

Fresh water resources are scatted throughout the district and are under fishculture on extensive or semi intensive way giving some income to the growers. The number of ponds, tanks, etc. has significantly increased in last few years. The development of fisheries in these fresh water resources is the present need using scientific techniques. There is no limnological study of fish pond has been made to improve the pond productivity. The abiotic and biotic factors of the water influence the quality and quantity of aquatic life surviving there. The role of water in nature is unique not only for human; but, also for the numerous organisms living in the water. The physical and chemical properties of fresh water bodies are characterized by the climatic, geochemical, geo morphological and pollution condition. In order to utilize fresh water bodies successfully for fish production, it is very important to study the Physico-Chemical factors influencing the biological productivity in the water bodies (Sahni and Yadav, 2012).
EFFECTIVE COMMUNICATION AND THE ROLE OF ENGLISH IN A GLOBAL WORLD: A CRITICAL ANALYSIS
Authors: Dr. Sanjib Kumar Barman
Published: October 2024

English is the most widely used and popular language in the present world. It has been statistically reported that around half of the population of the world speak in English. English is used as mother tongue in many countries. But the people using other than English as a mother tongue have to learn English to cope up with the present day to day life. However, it is also true that mother tongue plays a crucial role in shaping our thoughts and moulding the future lives. It is really praise worthy that Government of India has emphasized in the use of mother tongue in the primary level in NEP 2020. The need to learn English language cannot be ignored in this world of globalization. Moreover, English is a language of technology. The use of internet is almost impossible without knowing English. The importance of English language is seen in many fields of international significance. In the recent years many nations have made English as their chief foreign language in schools and colleges for the most important reasons which is always educational. The demand for a language which is universally intelligible is widely felt and frequently voiced. The need of the hour is to enlighten the future aspirants in the academic discipline that rests on functional relevance. This paper aims to explain how English language has become essential for the people around the world.
CREDIT CARD FRAUD DETECTION USING A STACKING ENSEMBLE APPROACH WITH LSTM AND RANDOM FOREST MACHINE LEARNING TECHNIQUES
Authors: Varun Chellapilla  , Sravya Chikkam  , Jayanth Sriram Melinati  , Mr. M. Ezhilarasan
Published: October 2024

Credit cards play an essential role in today’s digital economy, and their usage has recently grown tremendously, accompanied by a corresponding increase in credit card fraud. Machine learning (ML) algorithms have been utilized for credit card fraud detection. However, the dynamic shopping patterns of credit card holders and the class imbalance problem have made it difficult for ML classifiers to achieve optimal performance.
This research project aims to develop a reliable credit card fraud detection system through a stacking ensemble method, integrating LSTM and Random Forest machine learning techniques. This approach aims to enhance fraud detection accuracy by leveraging the diverse strengths of both models. The system will undergo rigorous evaluation to ensure its efficiency in identifying fraudulent transactions while minimizing false positives. By combining the temporal sequencing capabilities of LSTM with the decision-making process of Random Forest, the proposed approach seeks to achieve heightened sensitivity to fraudulent patterns while maintaining computational efficiency. Ultimately, the objective is to bolster security measures and protect financial institutions and consumers from potential fraud risks.
THE ZOOPLANKTON DIVERSITY AND COMPOSITION IN KORI DAM OF BILASPUR, CHHATTISGARH, INDIA
Authors: Rama Mishra
Published: October 2024

Zooplankton are used to assess the environmental condition of bodies of water. The amount of zooplankton present is an indication of how productive a water body is. Revealing the quantity and variety of zooplankton in a water body can confirm its overall health. This current research explores the makeup and variety of zooplankton in the Kori dam located in Bilaspur, Chhattisgarh .The water samples were collected, once in a month, in the morning hours between 9:00AM and 11:00AM at four different sites (Site-I, Site-II, Site-III and Site-IV) of the dam. The surface water samples were filtered through a plankton net consisting of bolting silk cloth no. 20 to collect them. The planktons were then carefully placed on a slide, and the counting was conducted using a microscope. Throughout the study duration from July 2022 to June 2023, a total of 26 zooplankton species were discovered in various locations within Kori dam. The zooplankton species found in Kori dam comprised 15 rotifers, 2 protozoa, 5 cladocera, and 4 copepoda. Among the four zooplankton groups, rotifers were the most prevalent, constituting 57.19% of the total number of organisms, followed by protozoa at 19.04%, cladocera at 11.63%, and copepoda at 12.14% respectively.The overall The diversity indices indicate that there is a wide variety of zooplankton groups in this body of water, with the exception of protozoa, which had the lowest diversity indices values and the lowest abundance. To preserve the floral and faunal diversity in the future, it is necessary to implement a conservative strategy for this water body.
"COMPARATIVE ANALYSIS OF EPICS"
Authors: Dr. Umar Farooque
Published: October 2024

This paper presents a comprehensive comparative analysis of epics across different cultures, delving into their intricate narratives, thematic underpinnings, and socio-cultural significance. Epics, as timeless literary masterpieces, serve as repositories of cultural heritage and collective memory, embodying the ethos and values of diverse civilizations. Through a comparative lens, this study aims to elucidate the commonalities and divergences among epics, shedding light on the universal themes that resonate across human experiences while also highlighting the nuances shaped by specific cultural contexts.
Drawing upon a diverse array of epic traditions such as the Indian Mahabharata, the Greek Odyssey, the Norse Edda, and the African Sundiata, among others, this analysis navigates through the rich tapestry of myth, legend, and heroic exploits. It examines the archetypal motifs of heroism, fate, and the struggle between good and evil, which permeate these narratives, transcending geographical boundaries and temporal epochs.
Furthermore, this comparative study explores the socio-cultural functions of epics, elucidating their roles in shaping collective identity, moral codes, and societal norms. By juxtaposing epics from different cultures, this research seeks to unravel the intricate interplay between myth and history, oral tradition and written text, and the dynamic process of cultural transmission and adaptation.
Through this interdisciplinary approach, this paper contributes to a deeper understanding of the human condition, elucidating how epics serve as mirrors reflecting the aspirations, fears, and aspirations of humanity across epochs and geographies. Ultimately, this comparative analysis endeavours to foster cross-cultural dialogue and appreciation, recognizing the enduring relevance and timeless allure of epic literature in the global mosaic of human civilization.
EFFECTS OF DEFICIENT DIETARY INFORMATION, WITH A FOCUS ON THE WORKING CLASS OF INDIA
Authors: Viraaj Jaiswal
Published: October 2024

Maintaining dietary equilibrium is essential for the well-being of individuals and future generations. However, a significant portion of the Indian population, specifically the working class, lack access to adequate dietary information and resources. This impedes their ability to maintain a balanced diet. This paper explores the importance of adequate nutrition, the dire ramifications of its absence, and possible solutions to this deficiency in nutrition. Using research techniques such as case studies and government data analysis, the paper investigates the current state of nutrition in India, particularly among the working class. It identifies cases of inadequate nutrition and food poisoning and their causes. The findings reveal that many Indians do not meet their daily nutritional requirements, with common deficiencies in vitamins B12 and D3, zinc, iron, calcium, folic acid, and Vitamin C. This inadequacy’s root causes are traditional dietary practices, vegetarianism, and, most importantly, the lack of dietary education and information among the working class of India. These nutritional deficits contribute to health issues such as obesity, heart disease, strokes, type 2 diabetes, and various cancers. Furthermore, food poisoning poses a significant threat to one's health, causing numerous deaths annually. Several methods of improvement for this bleak situation were deduced, such as awareness campaigns, collaborations between healthcare practitioners and schools or community centers, and the distribution of educational pamphlets in local languages, making dietary information easily accessible to the masses.
CRITICAL REVIEW OF SOCIAL SECURITY WELFARE SCHEMES RUNNING FOR CASUAL LABOURERS IN INDIA
Authors: Deepak Kumar  , Prof. (Dr.) Niranjan Lal
Published: October 2024

This research Paper is based on the objective of critically analysing the welfare schemes running for casual labourers in India. Casual Labourers comes from the informal sector of the economy and they do not have much required social security. They face lot of problems like low wages, long working hours, miserable working conditions, poor quality of life, low access to health, education and other basic facilities like housing, clean drinking water, good quality of food etc.
In order to help them, many social security schemes are running in the country. Among them major ones are Pradhan Mantri Jeewan Jyoti Beema Yojana (PMJJBY), Pradhan Mantri Suraksha Bima Yojana (PMSBY), Ayushman Bharat, Pradhan Mantri Shram Yogi Maan Dhan (PM-SYM) Pension Scheme, One Nation One Ration Card, Mahatma Gandhi National Rural Employment Guarantee Act, Pradhan Mantri Awas Yojana, Pradhan Mantri Kaushal Vikas Yojana. Their knowledge about the welfare schemes is very low due to lack of awareness and illiteracy. Hence, being in a situation of dilemma, they are unable to take the benefits of the welfare schemes properly. This research paper aims at the critical review of these schemes and also focuses on finding the difficulties faced by casual labourers in achieving the benefits of these schemes, with the help of interview schedule method by taking interview of 100 workers of Kanpur Nagar.
The major findings include improper implementation of welfare schemes due to corruption in some cases and poor execution of the objectives of the schemes at grass root level. Casual labourers also find it very difficult to understand properly about all the objectives of the schemes as they are not aware of the rules and regulations about a particular scheme. It seems that awareness campaigns, easy rules of execution of the schemes and regular quality check is required to make things better.
A COMPREHENSIVE STUDY ON WORKING JOURNALISTS IN MANIPUR, INDIA
Authors: Dr. Khaidem Sunita Rani
Published: October 2024

This article meticulously analyzes the status of working Journalists in Manipur. Manipur, however small it is, is the home of more than 33 listed scheduled tribes apart from the Meities, Meitei Pangals and 7 scheduled castes. Each community has distinct identity, dialect and culture for which everyone is struggling for due recognition of its identity within this tiny state. Reported cases of violations of human rights such as extrajudicial killings, enforced disappearance, torture and threats have become a part of daily news in Manipur. People of Manipur are the victim of parallel government.
This study is founded on primary and secondary data, with the primary data being collected through interviews.
A STUDY ON GENDER DISPARITY AND LITERACY RATE IN RELATION TO POPULATION WITH SPECIAL REFERENCE TO MURSHIDABAD DISTRICT OF WEST BENGAL, INDIA
Authors: Arfi Anjoon
Published: October 2024

Murshidabad enjoyed a rich history in terms of trade, industry, agriculture, politics, education, and culture during a protracted span of the ancient and medieval periods. Currently, however, the district stands far behind other regions of the nation in terms of socioeconomic, cultural, and educational characteristics. Murshidabad District's general collapse started with the fall of Nawabi rules during the Battle of Plassey in 1757. Bengali Muslims who had previously held political and socioeconomic sway in the region lost both with the arrival of British administration. This place's population lacks awareness because of the educational system's backwardness. In the district, women participate at a far lower rate than males do, both in terms of economic activity and literacy. Expanding women's access to education is necessary to improve their situation.
DISINVESTMENT AND INDIA EFFECTS OF PRIVATIZATION ON ECONOMY AND SOCIETY
Authors: Dr. Anju Tiwari
Published: October 2024

This paper is in context to the reason or conditions in which Government initiate as entrepreneur and the conditions those are liable for need of disinvestment of public industries. Also discuss the effect of Privatization on Economy and Society of India. For that i choose a production unit as well as service providing unit working under government.
Paper also show the various methods of Privatization and analysis what would be the better combination of methods, where privatization is needed
CHILD MARRIAGE IN INDIA: A SERIOUS VIOLATION OF CHILD HUMAN RIGHTS
Authors: Dr. Jayashree Mukherjee
Published: October 2024

Child marriage has been practiced in India and other countries since ancient times. Before the physical and mental maturity of the children they get married, without their consent which is not only harmful for their overall development but also is harmful for the development of the country at large. Child marriage is a heinous and serious violation of Child Human Rights and is a punishable offence. Still this social evil is practiced in several parts of India and the entire world. Indian Government is striving hard to eradicate this evil, which is a serious factor for degradation of the society. The future generation gets adversely affected by this evil. Several steps have been taken by the government of India to stop this evil. This paper discusses child marriage in details- the reason behind, the consequences and the probable solutions that will help India to fight against this social evil and stop child marriage. This paper specially emphasised the ill effects of child marriage on girls, who are more effected by this evil and which can even be life threatening for them.
Educational innovation: Exploring the Potential of Generative Artificial Intelligence in cognitive schema building
Authors: Salgado Granda Bernarda , Inzhivotkina Yana , Ibáñez Apolo María Fernanda , Ugarte Fajardo Jorge Gustavo
Published: October 2024

This study explores the use of generative artificial intelligence to enhance teaching and learning experience, focusing on strengthening and consolidating cognitive schemas. Research reveals that schemas can profoundly influence the improvement of the learning experience and promote the assimilation of new types of information and retention in students' memory. To improve the teaching and learning experience, the advantages, obstacles, and potential future trajectories of utilizing these technologies were examined by conducting a thorough literature review and analyzing relevant studies. Findings indicate that generative artificial intelligence has the potential to personalize learning, diversify educational content, and improve teaching efficiency and scalability. However, it also poses challenges related to content quality, data privacy, and equity in access to personalized learning. Future research should focus on the effectiveness of educational tools based on generative AI that promote equity and inclusion, ethical approaches, and interdisciplinary collaboration. Overall, this study provides a solid foundation for understanding and harnessing the potential of generative artificial intelligence in enhancing cognitive schemas, thereby promoting more effective, inclusive, and personalized education.
NOWE REGULACJE PRAWNE DOTYCZĄCE BADAŃ KLINICZNYCH – WYBRANE ZAGADNIENIA ADMINISTRACYJNOPRAWNE
Authors: Trębska Aleksandra
Published: October 2024

Kryzys związany z pandemią COVID-19 uwidocznił nieprzygotowanie UE w dziedzinie zdrowia publicznego, w tym dostępu do nowych terapii, ale zobrazował też możliwości oraz pole do dalszych działań. Celem tego opracowania jest przedstawienie nowych inicjatyw oraz uwarunkowań prawnych w kwestii badań klinicznych nowych produktów leczniczych z punktu widzenia szans i zagrożeń dla zdrowia publicznego. W ramach analizy omówiono wybrane zagadnienia dotyczące unijnego rozporządzenia 536/2014 oraz ustawy o badaniach klinicznych. Ponadto poruszono bieżące inicjatywy UE w zakresie zdrowia publicznego oraz nowej strategii farmaceutycznej dla Europy w kontekście problematyki zdrowotnego bezpieczeństwa obywateli.
ZAGADNIENIE PRAW PACJENTA WOBEC ZAGROŻENIA EPIDEMIĄ COVID-19. ODNIESIENIA POLSKIE
Authors: Tykwińska-Rutkowska Dominika
Published: October 2024

Prawa pacjentów oparte na podstawowych prawach człowieka do godności, życia, zdrowia, integralności czy samostanowienia są ich fragmentem i konkretyzacją wyrastającą ze wspólnego poczucia zagrożenia praw podmiotowych. Będąc wyrazem upodmiotowienia pacjenta, stanowią istotny mechanizm zapewnienia mu bezpieczeństwa w relacjach z osobami wykonującymi zawody medyczne. Odgrywają też istotną rolę w rozwoju systemów opieki zdrowotnej i upowszechnieniu dostępu do świadczeń zdrowotnych. W związku z doświadczeniami współczesnych zagrożeń o charakterze zdrowotnym typu COVID-19 powstaje pytanie, czy i jakie działania podejmuje administracja, by możliwe było wykonywanie tych praw, a zarazem by możliwe było zniwelowanie negatywnych skutków tych zagrożeń dla praw pacjentów.
PRAWO O OCENACH ODDZIAŁYWANIA NA ŚRODOWISKO JAKO DZIEDZINA MULTIDYSCYPLINARNA
Authors: Trzcińska Diana , Pchałek Marcin
Published: October 2024

Normy jakości poszczególnych elementów środowiska, których dochowanie weryfikowane jest w toku postępowań w przedmiocie oceny oddziaływania przedsięwzięć na środowisko, mają charakter zróżnicowany w zależności od metodologii oceny stanu środowiska lub jego poszczególnych elementów oraz metodologii oceny oddziaływania na dany element środowiska. Generalnie można wyróżnić normy ilościowe (parametry emisyjne i imisyjne) oraz jakościowe (właściwy stan ochrony siedlisk i gatunków, właściwy stan parametrów hydromorfologicznych, stan walorów krajobrazu itd.). Weryfikacja wskazanych norm następuje w praktyce na podstawie dokumentacji przedkładanej w postaci materiału dowodowego ze wszystkimi tego skutkami w zakresie reżimu oceny dowodów w rozumieniu przepisów o postępowaniu administracyjnym. Metodologia oceny stanu elementów środowiska oraz oddziaływania przedsięwzięć jest zróżnicowana, w szczególności w zależności od poziomu zaawansowania sieci Państwowego Monitoringu Środowiska, dostępnej wiedzy, instrumentów inżynieryjnych, a także od wytycznych i praktyki Komisji Europejskiej/krajowych organów administracyjnych. Materiał dowodowy na potrzeby stosownych postępowań administracyjnych opracowywany jest na styku między innymi nauk fizycznych, chemicznych, biologicznych, hydrobiologicznych, hydrogeologicznych oraz ekonomicznych. Nierzadko prowadzone analizy wykorzystują zaawansowane technologie modelowań matematycznych, których założenia są następnie przedmiotem postępowania wyjaśniającego w indywidualnych sprawach administracyjnych. Problematyka ocen oddziaływania na środowisko jest zarazem swoista i charakterystyczna dla prawa ochrony środowiska, stanowiąc jednocześnie w jego ramach instytucję rozumianą jako złożony w oparciu o rozmaite relacje zespół powiązanych ze sobą funkcjonalnie norm społecznych skorelowanych przez wspólny cel i wartość, przypisaną tej instytucji jako takiej, trwający w czasie i ewoluujący bez utraty swej integralności. Nie przeczy temu założenie badawcze, że system norm prawnych, które tworzą tę instytucję od strony materialnej, procesowej i ustrojowej, stanowi jednocześnie wyspecjalizowaną dziedzinę prawa ochrony środowiska o multidyscyplinarnym (wielobranżowym) charakterze. W konsekwencji w analizę tych oddziaływań na różnych poziomach wpisana jest ich ocena z perspektywy różnych, wskazanych wyżej nauk i dziedzin wiedzy, co znacznie komplikuje proces podejmowania decyzji w tego typu sprawach, a następnie proces ich weryfikacji w ewentualnych postępowaniach sądowych. Celem niniejszego artykułu jest więc weryfikacja postawionego wyżej założenia badawczego poprzez zilustrowanie złożoności zagadnienia stosowania materialnych i procesowych norm prawa ochrony środowiska z perspektywy multidyscyplinarnego charakteru analiz koniecznych do dokonania w toku procesu decyzyjnego oraz przedstawienie wniosków odnośnie do efektywności regulacji prawnośrodowiskowych i procesowych dotyczących realizacji przedsięwzięć mogących znacząco oddziaływać na środowisko.
ZAPYTYWANO I SPIERANO SIĘ, CZY PREFEKT POWOŁANY NA CZAS ŚWIĘTA LATYŃSKIEGO MA PRAWO ZWOŁANIA I ZAPYTYWANIA SENATU O ZDANIE AULUS GELLIUS, ‘NOCE ATTYCKIE’ 14,8 TEKST – TŁUMACZENIE – KOMENTARZ
Authors: Tarwacka Anna
Published: October 2024

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UDZIAŁ WŁAŚCICIELI NIERUCHOMOŚCI W KOSZTACH BUDOWY URZĄDZEŃ INFRASTRUKTURY TECHNICZNEJ FINANSOWANYCH ZE ŚRODKÓW PUBLICZNYCH – AKTUALNE PROBLEMY
Authors: Pracka Małgorzata
Published: October 2024

Wartość nieruchomości zależy od wielu czynników. Budowa urządzeń infrastruktury technicznej czy też wybudowanie drogi niewątpliwie wpływa na atrakcyjność nieruchomości oraz na jej wartość. Zaangażowanie środków publicznych w budowę tych urządzeń lub budowę drogi stanowi wymierną korzyść dla właścicieli nieruchomości. Ustawodawca stworzył zatem instrument w postaci opłaty adiacenckiej, za pomocą którego gmina uprawniona została do pobrania tej daniny publicznej będącej wyrazem uczestnictwa właścicieli nieruchomości w kosztach budowy urządzeń infrastruktury technicznej. Niniejszy artykuł podejmuje problematykę dotyczącą przesłanek uprawniających gminę do naliczenia opłaty adiacenckiej wraz ze wskazaniem materialnoprawnych podstaw jej naliczenia. Konﬂiktogenny charakter tej opłaty, mimo istnienia podstaw ustawowych do jej pobrania, sprawia, że w praktyce występują często poważne problemy interpretacyjne, które wymagają wyjaśnienia.
MIĘDZY OCHRONĄ ŚRODOWISKA A OCHRONĄ WŁASNOŚCI W GOSPODAROWANIU PRZESTRZENIĄ NA POZIOMIE LOKALNYM
Authors: Sachanbińska-Dobrzyńska Olga
Published: October 2024

Kryzys klimatyczny stanowi podstawę pogłębionej dyskusji nad skutecznymi rozwiązaniami służącymi ochronie środowiska. Akcentowanie w dyskursie prawniczym wyłącznie konieczności ochrony środowiska może jednak stwarzać zagrożenie umniejszeniem znaczenia własności prywatnej. Należy zatem poszukiwać ram prawnych dla obiektywnej i rzetelnej kontroli zakazów i ograniczeń wprowadzanych pod tym hasłem przez organy administracji publicznej. Niniejsze opracowanie stanowi próbę odpowiedzi na pytanie o warunki oraz granice ingerencji w prawo własności przez lokalne instrumenty gospodarowania przestrzenią w zakresie ochrony środowiska. Zaprezentowane zostaną determinanty proporcjonalności naruszeń prawa własności, znaczenie zasad wykładni in dubio pro libertate oraz in dubio pro natura, a także problemy prawne związane z opracowaniami ekofzjografcznymi oraz z uchwałami rady gminy wprowadzającymi formy ochrony przyrody. W końcowej części podsumowane zostaną postulaty de lege oraz de sententia ferenda.
Identification of Gene Signatures Associated with COVID-19 across Children, Adolescents, and Adults in the Nasopharynx and Peripheral
Blood by Using a Machine Learning Approach
Authors: Bao YuSheng , Ren JingXin , Chen Lei , Guo Wei , Feng KaiYan , Huang Tao , Cai Yu-Dong
Published: October 2024

Background:

Significant variations in immune profiles across different age groups manifest
distinct clinical symptoms and prognoses in Coronavirus Disease 2019 (COVID-19) patients.
Predominantly, severe COVID-19 cases that require hospitalization occur in the elderly, with the
risk of severe illness escalating with age among young adults, children, and adolescents.

Objective:

This study aimed to delineate the unique immune characteristics of COVID-19 across
various age groups and evaluate the feasibility of detecting COVID-19-induced immune alterations
through peripheral blood analysis.

Methods:

By employing a machine learning approach, we analyzed gene expression data from nasopharyngeal
and peripheral blood samples of COVID-19 patients across different age brackets.
Nasopharyngeal data reflected the immune response to COVID-19 in the upper respiratory tract,
while peripheral blood samples provided insights into the overall immune system status. Both datasets
encompassed COVID-19 patients and healthy controls, with patients divided into children,
adolescents, and adult age groups. The analysis included the expression levels of 62,703 genes per
patient. Then, 9 feature-sequencing methods (least absolute shrinkage and selection operator, light
gradient boosting machine, Monte Carlo feature selection, random forest, ridge regression, adaptive
boosting, categorical boosting, extremely randomized trees, and extreme gradient boosting) were
employed to evaluate the association of the genes with COVID-19. Key genes were then utilized to
develop efficient classification models.

Results:

The findings identified specific markers: insulin-like growth factor binding protein 3
(downregulated in the peripheral blood of COVID-19 patients), interferon alpha-inducible protein
27 (upregulated), and SERPING1 (upregulated in nasopharyngeal tissues). In addition, fibulin-2
was downregulated in adolescent patients, but upregulated in the other groups, while epoxide hydrolase
3 was upregulated in healthy controls, but downregulated in children and adolescents.

Conclusion:

This study offers valuable insights into the local and systemic immune responses of
COVID-19 patients across age groups, aiding in identifying potential therapeutic targets and formulating
personalized treatment strategies.
Role of Nrf2 in Epilepsy Treatment
Authors: Azadmanesh Maryam , Farkhondeh Tahereh , Harifi-Mood Mohammad Sadra , Aschner Michael , Samini Fariborz , Samarghandian Saeed
Published: October 2024

Oxidative stress is a consequence of the disruption of the balance between
the generation of reactive nitrogen and oxygen species and the biological system’s
ability to neutralize those reactive products. Oxidative stress is involved in the
generation of many disorders, including epilepsy, which is a prevalent chronic
neurological disease that affects the lives of millions of people around the world.
Epilepsy is characterized by unforeseeable and repeated seizures that can be very
disturbing. Studies have reported that oxidative stress occurs before and after
seizures. A transcription factor named Nuclear factor erythroid-derived 2-related factor
2 (Nrf2) controls genes related to the induction of oxidative stress and defends cells
against oxidative stress. The Nrf2 protein has seven different domains, ranging from
Neh1 to Neh7. Each domain is responsible for a distinctive function of this protein.
Keap1 binds to Nrf2, but during oxidative stress, Nrf2 detaches from the Keap1
protein, moves to the nucleus, and binds to DNA. The result of this translocation and
binding is the initiation of transcription of detoxifying genes to control the harmful
effects of oxidative stress. There is some evidence of oxidative stress involvement in
epilepsy. In this review, we have listed potential Nrf2-related therapeutic targets for
treating and controlling epilepsy, such as Berberis alkaloids, pentoxifylline, lovastatin,
progesterone, and chrysin nanoparticles. These activators were tested in animals (in
vivo) and cells (in vitro), and most of these experiments showed promising results in
different epilepsy models. Finally, the results have suggested that the activation of Nrf2
can be an option for controlling epilepsy.
Phase I Clinical Trial of CD19 CAR-T Cells Expressing CXCR5 Protein for the Treatment of Relapsed or Refractory B-cell Lymphoma
Authors: Wang Jiaxi , Jiang Yirong , Luo Min , Lu Wenyi , He Jixiang , Zhang Meng , Yao Zhuoxin , Jin Xin , Xiao Xia , Chen Jianhang , Li Guangchao , Ding Wen , Zhou Jie , Zhang Zhiyin , Zhao Mingfeng
Published: October 2024

Background:

It is difficult for CD19 CAR-T cells to enter solid tumors, which is one reason for their poor efficacy in lymphoma treatment. The chemokine CXCL13 secreted by stro-mal cells of the lymph nodes induces the homing of B and T lymphocytes, which express its receptor CXCR5. Preclinical trials have shown that the expression of CXCR5 on CD19 CAR-T cells can increase their migration to the tumor microenvironment and enhance their antitumor function.

Methods:

We engineered the CD19 CAR-T cells to express a second receptor, CXCR5. Then, we conducted a phase I clinical trial to evaluate the safety and efficacy of CXCR5 CD19 CAR-T cells in the treatment of relapsed or refractory (R/R) B-cell lymphoma.

Results:

We recruited 10 patients with R/R B-cell lymphoma undergoing CXCR5 CD19 CAR-T cell therapy. The objective response rate was 80%, and the complete response rate was 50%. The median follow-up time was 15.48 months (3.4-22.3 months), and the median Progression-Free Survival (PFS) time was 8.15 months (1.5-22.33 months). One patient received ASCT at 1.5 months (at PR) after infusion of CAR-T cells. The incidence of grade 1 and grade 2 Cytokine Release Syndrome (CRS) was 70% and 20%, respectively. No patient experienced grade 3 or higher levels of CRS, neurotoxicity, or infusion-related dose toxicity.

Conclusion:

The results obtained in this study suggest that CXCR5 CD19 CAR-T cells should be investigated in a trial with broader patient populations.

Trial Registration:

The trials were registered at www.chictr.org.cn as ChiCTR2100052677 and ChiCTR1900028692.
Describing the Accumulation, Concentration, and Amplification Effects of MPs Through the Food Chain
Authors: Dagdelen Ulku , Turkyilmaz Dogan , Esenbuga Nurinisa
Published: October 2024

Microplastics (MP) are new pollutants that threaten the ecological environment and,
therefore, human and animal health. Given the extensive utilization of plastics across various domains,
MPs are commonly detected in the atmosphere, water bodies, terrestrial regions, and living
organisms. Important accumulation points of MPs are air, soil, and water ecosystems. This study
aims to summarize how animals are exposed to environmental MPs, identify the specific organs
where these MPs accumulate, and assess the risks associated with different foods. The urrent research
on MP pollution in ecosystems generally focuses on organisms living in water and soil, but
unfortunately, there are significant deficiencies in the transmission routes of MPs in the food
chain from soil to table. MPs build up in animals across the food chain, and their presence in animal-
derived food products intensifies during processing and packaging. The transfer of MPs to
food-producing animals has been understudied, particularly with regard to the important role of
livestock in converting plant nutrients into proteins required for human consumption. It is understood
that more research is needed, especially for contamination in animal foods. Conducting comprehensive
risk assessments of MPs throughout the entire food chain is extremely important for
food safety.
Formulation and Evaluation of Lungs-Specific Doxorubicin-Loaded Chitosan-PLGA-Alginate Polymeric Nanoparticles
Authors: Shukla Shalu , Pandit Vinay
Published: October 2024

Background:

An antibiotic called doxorubicin is produced by the Streptomyces peuce-tius bacterium, which is a member of the anthracycline drug class and is used in chemotherapy. Usually, doxorubicin is employed to cure solid tumors in children and adult patients. The physical and biological stability of the medicine can be increased by encasing it in nanoparticles, which increases the active pharmaceutical ingredient's bioavailability.

Objective:

This study aimed to create lungs targeting doxorubicin-loaded biodegradable polymer-ic nanoparticulate system by utilizing an appropriate method and conducting its evaluation.

Methods:

The polymeric nanoparticles using biodegradable polymers were prepared by the emul-sion polymerization method. Franz- diffusion cells were utilized to conduct in-vitro drug diffu-sion investigations.

Results:

Based on the outcomes of the experiments carried out for the research, polymeric nano-particles of doxorubicin were prepared utilizing different concentrations of chitosan, Sodium al-ginate, and PLGA. The visual appearance of doxorubicin polymeric nanoparticles shows homo-geneous dispersion with no phase separation form. The percentage yield, % entrapment efficien-cy, and drug content obtained for the final formulation were 93.43 ± 1.776, 87.31 ± 1.075, and 91.98 ± 0.493, respectively. A size dimension of 174.51 nm with a PDI of 0.242 and zeta poten-tial value of -36.1 mV of prepared nanoparticles demonstrate the stability of the formulation. The presentation of the PNPs of the optimized formulation having 310mg Tween 80 showed in vitro diffusion of 98.93% ± 0.296 % and an increased flux rate. Based on the determination coeffi-cients, the Higuchi model (K0 = 20.43 and R2= 0.982) was determined to have the best fit for the release data.

Conclusion:

Based on the trials conducted during the investigation, it was determined that the emulsion polymerization technique was best for the fabrication of the polymeric nanoparticles by utilizing different concentrations of chitosan, Sodium alginate, and PLGA. The formulation F6 containing 310mg Tween 80 suggested improved in vitro diffusion following the Higuchi model throughout all formulations. The findings suggest that a sustained process was responsible for the drug's release from the doxorubicin polymeric nanoparticles.
Living on a Picture: Approaching Images and Life Stories in Social Media
Authors: Galván García de las Bayonas Ana Isabel
Published: October 2024

If images were once conceived either as subordination or oppositions of words, the advent of the Internet has started new relationship dynamics between them. Within this digital scenario, vision and textuality intensely intertwine in the form of captions, posts, hyperlinks or other kind of social media content, daily handled by users. In this context, autobiographical narratives will take on a major role, shaping the way in which the subject conceives, forges and registers his or her identity in relation to the reader/viewer. This article aims to address the question, more present than ever, of how certain autobiographical narratives are disseminated through social networks, and how image and narrative dialogue within this framework. By addressing specific cases found on platforms such as Instagram, we will try to elucidate how these publications point to an ambivalent relationship with visual tropes or narratives associated with certain life experiences, either questioning it or contributing to the creation of a collective narrative. A complex interplay of image and narrative that will affect not only how we share life, but also how we understand it and construct it together with others in a changing world.
Writing the Lone Mother’s Lifetime: Peter Handberg’s Den vita fläcken
Authors: Wahlström Henriksson Helena
Published: October 2024

This article offers an analysis of a son’s ‘relational auto/biography’ of his lone mother; Swedish author Peter Handberg’s novel Den vita fläcken (The White Spot 2015). It focuses on how the book builds a sense of the mother Gunhild’s lifetime through the use of three different temporal dimensions: historicization, extension, and relational weaving of life courses. Matrifocal books by sons are interesting in several ways. First, in that they counter the gendered convention of sons’ patrifocal auto/biography, and cross over to the matrifocal auto/biography that has typically been linked to the mother-daughter relationship. Second, in contrast to patrifocal narratives that typically attempt to recover the parent who was absent or lost, they attempt to tell the story of the always-present parent: the mother. In their description of a close, ongoing, and often loving – although seldom unproblematic – relationship between a (now middle-aged) son and his mother, they furthermore counter ingrained cultural myths that envision ‘mother-son separation as the precondition of manhood’ (O’Reilly 2016, 15). Therefore, I argue, while sons’ auto/biographical writing about their lone mothers can be an inroad to investigating how subjective narratives of (lone-parent) family lives are constructed in life writing, they can also be inroads to re-thinking conventional genderings in literary studies.
The diversity of fungal associates of Dendrobium ovatum (L.) Kraenzl., an endemic orchid of the Western Ghats of India
Authors: Raj Reedhu , Job Joseph , Rajan Prasanna , Mathew Sijo , Ramanathan Rasmi Avanoor , Cherian Elizabeth
Published: October 2024

Dendrobium ovatum is a tropical epiphytic orchid endemic to the Western Ghats of India and has been listed as a threatened species in recent research due to its declining populations and changes in flowering and fruit set patterns. This study aims to investigate the mycoflora associated with the roots, stems and leaves of D. ovatum. Both surface‐associated and endophytic fungal associates were isolated and identified using morphological and molecular methods. The study resulted in the isolation of 139 cultures, which were divided into 24 morphotypes, 99% of which belonged to Ascomycota. The most dominant members, Trichoderma harzianum and Colletotrichum gloeosporioides, were consistently observed across all the study sites. Tissue‐specific fungal diversity analysis revealed that each organ was dominated by a distinct fungal group, forming characteristic communities specific to each tissue. The roots of D. ovatum exhibited the highest species richness and diversity, compared to the stem and leaves. This research also represents the first documentation of fungal associates of the threatened orchid D. ovatum.
Standardization Eﬀorts for Ayam Goreng Kalasan Industry Cluster Through a Partnership Between the University and Local Government to Maintain its Local Wisdom
Authors: Sukartiko Anggoro Cahyo , Supartono Wahyu , Zaidir Zaidir , Neisyafitri Rendayu Jonda , Setiyono Rahmat
Published: October 2024

A community service partnership is carried out between a universityand a local government to standardize processes and products produced by theAyam Goreng Kalasan industry cluster. Eﬀorts are made through a series offocused discussion activities, knowledge sharing, and material provision, as wellas training and mentoring on aspects of standardization, product diversiﬁcation,and promotion toward marketing with a broader scope. The ﬁrst three stageswere carried out with the involvement of local government. The results ofthe community service implementation were measured using a comparison ofknowledge of business actors before and after the implementation of the activities.A total of 31 business actors, as members of the Ayam Goreng Kalasan MajuMakmur industry cluster, have participated in this activity. Increased knowledgeis observed in all aspects: standardization, diversiﬁcation, management, andmarketing. The collaboration between the university and the local government,therefore, can increase the participation of business actors, accelerate the requiredstandardization and certiﬁcation process, and further increase the possibility ofsustainability of cluster business development.
Boosting Competitiveness: Digital Branding of The Sreseh Mangrove Tourism Spot in Marparan Village
Authors: Rachman Fika Hastarita , Wahyuni Sri , Imamah Imamah
Published: October 2024

Tourism acts as a conduit for enhancing the economic conditionsof villages located near tourist destinations. Sreseh Mangrove Tourism (WMS) inMarparan Village is a recently established tourist destination in Sampang Regency.The Tourism Awareness Group (Pokdarwis) faces various obstacles in managing andconserving nature. These factors encompass the local population’s limited levelof technology skills and the absence of digital branding as a means of promotion.Digital branding is a very eﬃcient promotional tool in the current technology agedue to its ability to engage with social media users rapidly. Producing captivatingcontent is essential as it has a favorable impact on public opinion and draws peopleto tourist destinations. In order to tackle this issue, we have established a programaimed at improving Pokdarwis’ proﬁciency in utilizing technology for promotionalpurposes. This curriculum encompasses instruction, development, and supportin the realm of digital branding. The program was successfully implemented,substantially enhancing participants’ proﬁciency in generating digital material. Theparticipants’ videos were posted on Marparan Village’s Instagram page. There arepotential prospects for creating a mobile application in the future that includesdigital content videos, digital promotions, and a directory of rental and vacationchoices.
Children’s Historical Literacy Improvement Program for The First Graders at Brawijaya Smart School
Authors: Nurhayani Ika , Hariyanti Rosana
Published: October 2024

This community service aimed to improve the historical literacy of the ﬁrstgradestudents at the Elementary School of BSS (Brawijaya Smart School) regardingthe history of Malang. BSS Elementary School is located in Malang City, East Java.The community service activity consisted of writing and publishing a book about oneof the cultural heritages of Malang, distributing it to the ﬁrst graders, and organizinga storytelling performance based on the book. The community service team chosethe classical history displayed in the Jago Temple, built in the 13th century during theSinghasari period. The temple is located in Malang Regency. This activity received agood response from the homeroom teacher and the ﬁrst-grade students of the BSSelementary school. The students expressed their interest in learning more about thehistory of Malang. It can be concluded that this community service has been successfulin improving the historical literacy of the students about their city.
Rice Pricing as Perceived by Stall Owner in Talavera Public Market: A Basis for Market Development Plan
Authors: Malilay Joane Ramos , Orlanda Marjorie M. , Matias Effer Mark Joseph I M. , Manalili Eduardo G. , Cruz Lealynne Dela , Abat Rowena B. , Casimiro Ma. Kirsten Kaye M. , Corpuz Nomer T. , Reyes Jr. Roberto V. , Abad Mark Alvin H.
Published: October 2024

This study aims to develop a market development plan for rice retailers in Talavera Public Market by exploring the demographic profile of respondents and analyzing the pricing dynamics within the market. Utilizing a descriptive research design, data were collected to understand key factors influencing pricing, including rice quality, supply and demand, and competition. Findings indicate that most participants operate as sole proprietors, with a few in partnerships. The study highlights significant challenges faced by rice retailers, such as fluctuating costs, competitive pressures, and consumer perceptions of rice quality. These insights underscore the need for tailored strategies to address pricing inefficiencies and disparities in the rice market. Ultimately, the study proposes a market development plan to assist rice retailers in aligning their pricing strategies with market demands and consumer preferences.
Análisis del Desempeño del Consejo Consultivo del INAI: una Visión desde la Gobernanza
Authors: Uvalle Berrones Ricardo
Published: October 2024

Analizar el desempeño del Consultivo del INAI en las tareas que desarrolla desde la óptica de la gobernanza, como órgano que forma parte de los procesos institucionales que tienen como fin cumplir con la constitucionalidad y las normas jurídicas que se relacionan con la protección de los datos personales y el derecho de acceso a la información, eje fundamental que implica llevar a cabo diálogos, deliberación y argumentación, orientados a racionalizar que las tareas del órgano constitucional autónomo se cumplan, tomando en cuenta la opinión y posición de los miembros que integran el órgano mencionado en diversos temas que son de importancia para las personas e instituciones para vigilar, valorar y recomendar al Pleno del Instituto, razonamientos articulados con decisiones, políticas, programas y acciones
El gobierno de Andrés Manuel López Obrador: ¿fue de izquierda por su política social?
Authors: Bolívar Meza Rosendo
Published: October 2024

Durante el gobierno de Andrés Manuel López Obrador (2018-2024) se aplicó una política social que buscó garantizar que los derechos sociales tuvieran un carácter universal, además de que fueran considerados como responsabilidad del Estado. Se buscó el bienestar general de la población, aunque se dio prioridad a los grupos vulnerables. En su acepción más amplia, la izquierda puede ser entendida como fuerzas, grupos o actores sociales identificados con los intereses de las clases dominadas. Es por ello que en este artículo se analiza si por su política social este gobierno puede ser considerado de izquierda y por qué. Lo aquí abordado es un tema novedoso y reciente, de un proceso en construcción, que implica un primer acercamiento al tema, por lo que sus conclusiones no son todavía definitivas
El culto al poder en su representación simbólica. El sustrato teológico en los ritos políticos.
Authors: Prieto Vargas José Enrique
Published: October 2024

La fuerza de los símbolos se encuentra presente en el culto al poder político y en la persuasión de sus expresiones litúrgicas. El artículo versa sobre el sustrato simbólico del poder en occidente en su relación con lo sagrado. A partir de la filosofía y la teoría política, se analiza la persistencia del ámbito simbólico en el poder unipersonal de los gobernantes como un elemento de culto a la figura de autoridad. Por ello, es posible dilucidar el trasfondo simbólico de los ritos políticos desde la doctrina medieval del cuerpo del Rey hasta la persistencia del vínculo teológico y político en los Estados modernos
Andrews Catherine (2024). El primer constitucionalismo mexicano: Derechos, representación y diseño de los Poderes en la constitución federal (1824) y las Siete Leyes (1836). México. CIDE / Tirant lo Blanch.
Authors: Pantoja Morán David
Published: October 2024

Andrews Catherine (2024). El primer constitucionalismo mexicano: Derechos, representación y diseño de los Poderes en la constitución federal (1824) y las Siete Leyes (1836). México. CIDE / Tirant lo Blanch.
Ortiz Leroux, Sergio (2023). Democracia y capitalismo: entre la socialdemocracia y el neoliberalismo. México. Gedisa/UACM
Authors: González Ulloa Aguirre Pablo Armando
Published: October 2024

Ortiz Leroux, Sergio (2023). Democracia y capitalismo: entre la socialdemocracia y el neoliberalismo. México. Gedisa/UACM