bluuebunny/crossref_metadata_2025 huggingface dataset:
Cognitive Effects of Lurasidone and Cariprazine: A Mini Systematic
Review
Authors: Olivola Miriam , Bassetti Nicola , Parente Serena , Arienti Vincenzo , Civardi Serena Chiara , Topa Pietro Alessandro , Brondino Natascia
Published: July 2023

Cognitive deficits are associated with schizophrenia and show a progressive worsening, often
being unresponsive to treatment. New antipsychotic molecules acting as antagonist at the serotoninergic
5-hydroxytryptamine receptor 7 (e.g. lurasidone) or partial agonists at dopamine D3 receptor
(e.g. cariprazine) could have an impact on cognition in this patient group. The aim of the systematic
review is to explore the efficacy of lurasidone and cariprazine in improving cognition in both animal
models and human studies. The following terms: (lurasidone AND cognit*) OR (cariprazine AND
cognit*) were searched in Web of Science from inception to December 2021. We included all studies
that assessed changes in cognitive function after treatment with cariprazine or lurasidone. Of 201 selected
articles, 36 were included. Twenty-four articles used animal models (rats, mice and marmosets),
five evaluating the effects of cariprazine and 19 the effects of lurasidone. Twelve articles were clinical
studies (cariprazine n = 2; lurasidone n = 10). In both animal and human studies lurasidone showed a
greater efficacy on cognitive performance compared to placebo, quetiapine, ziprasidone or treatmentas-
usual. Cariprazine was superior to other antipsychotics in improving cognitive functions in both animal
and human studies. The cognitive effect of lurasidone could be explained by its potent antagonism
at the 5-HT7 receptors combined with partial agonism at 5-HT1A receptors. The pro-cognitive effect
of cariprazine is probably explained by its very high affinity for D3 receptors. Head-to-head studies
comparing lurasidone and cariprazine are needed to establish the “first-choice” treatment for cognitive
dysfunction associated with schizophrenia.
The Use of Enzyme Inhibitors in Drug Discovery: Current Strategies and
Future Prospects
Authors: Singh Kuldeep , Gupta Jeetendra Kumar , Pathak Devendra , Kumar Shivendra
Published: July 2023

Enzyme inhibitors are an important therapeutic agent in drug discovery, as they can be used
to manipulate biochemical pathways to treat a wide range of diseases. Current strategies for enzyme inhibition
involve the use of small molecule inhibitors, natural products, or peptide-based inhibitors. These
inhibitors can be used to target and modulate the activity of enzymes, which in turn can affect the
progression of a particular disease. The future of enzyme inhibitor-based drug discovery lies in the development
of more selective and potent inhibitors, as well as the ability to target enzymes that are involved
in multiple pathways. Additionally, there is significant potential for the use of enzyme inhibitors
in combination with other therapeutic strategies, such as gene therapy. Finally, the development of novel
computational strategies for the design and optimization of enzyme inhibitor-based drugs is an exciting
area of research. Such strategies could lead to the discovery of new and more effective inhibitors,
which would facilitate the development of improved treatments for a variety of diseases. Hence, this review
focuses on some techniques for the discovery of enzyme inhibitors and their applications as various
therapeutic agents.
A Brief Insight into Nanotherapeutic Approaches in the Management of
Analgesia
Authors: Garg Kritika , Kumar G. Santhana , Soni Arun , Pawar Saurav
Published: July 2023

Background:

Growing public awareness of chronic pain resulting from illness and injury
has prompted pharmaceutical researchers and drug corporations to create better, more targeted painkillers.
For effective pain management, prolonged analgesic medication delivery at the intended areas
continues to be a major problem such as addiction, tolerance and other serious side effects, which can
prolong suffering and decrease painkiller effectiveness.

Objective:

The present paper focuses on review of current advances in the field of pain treatment by
different nanoparticles formulations of various drugs, by enhancing their pharmacokinetic factors and
diminishing associated adverse effects.

Results:

According to literature survey, usage of nano-carriers enables the delivery of these drugs to
target locations with less systemic toxicity. Nanotechnology for varied therapeutic purposes, different
analgesics have been loaded onto different nano carriers, including those that are natural, synthetic,
and polymeric and proven to be beneficial in pain management.

Conclusion:

Overall, new nano based preparations and new ways to utilize existing medications in a
variety of circumstances is a multimodal approach to pain relief, have resulted in recent advancements
in the pharmacological management of pain.
Cartographic support issues in the Arctic Ocean studying and bathymetric investigation objectives in the Russian Arctic
Authors: Firsov Yu. G. , Zinchenko A. G.
Published: July 2023

The current state and issues of the bathymetric investigations of the Arctic Ocean are examined in the study. The main sources of bathymetric data in the Central Arctic region and Arctic seas are characterized. The main possibilities to solve these issues in order to improve the efficiency of oncoming bathymetric investigation in the Russian Arctic sector for solving the urgent practical and scientific tasks of the Russian Federation in the Arctic region are discussed. The problem of hydrographic investigation and marine cartography of the new high latitude routes in the Northern Sea Route and bathymetric investigations of the South-Eastern part of Gakkel Ridge which are important for the Russian extended continental shelf submission is covered as one of the main issues. The importance of a new hydrographic investigation at the high latitude routes in the East Siberian Sea in order to provide the possibility of year-round navigation for the large-tonnage Arc7‑class icebreaking liquefied natural gas carriers is especially emphasized. The questions of geoformation and ice satellite support for efficient navigation along the Northern Sea Route are considered. It is concluded that the poor hydrographic knowledge of the new high latitude route in the East Siberian Sea and the lack of electronic navigation charts will prevent the possibility of establishing the year-round navigation for Arc7‑class icebreaking liquefied natural gas carriers during the coming several years. It is stated that hydrographic investigations carried out on the sections of the Northern Sea Route must adhere to the requirements of the International Hydrographic Organization. The urgency of developing the state integrated bathymetric database for the Arctic Ocean including the arctic seas data along with the necessity of providing all Russian bathymetric data acquired in the Arctic region to the assigned national center is discussed. The FKU 280 ZKP VMF is proposed as such national center. The importance of bathymetric maps of the Arctic Ocean is noted. The main role of creating the electronic bathymetric maps using modern technology and analytical geomorphological mapping on the basis of the system-oriented morphological approach in Earth science is emphasised.
Features of fender protection application on uncrewed port tugs
Authors: Danilov O. O.
Published: July 2023

In this paper, the variants of the fender protection of traditional port tugs and the possibility of using this protection on unmanned vessels of such type are considered; the main elements of such protection are investigated. At present, the technical level of mechanisms, instruments and software allows creating unmanned and crewless vessels. One of the promising directions in the development of such vessels is port tugs, since having relatively large river and sea vessels they perform production tasks in the port water area and approaches to it. An integral part of the work of a port barthing tug or escort tug is bulks and approaches in tight to the towed object or vessel. The combination of a small size, the nature of the tasks performed and the widespread use of such vessels is one of the positive factors for the introduction of unmanned technologies on these vessels. There is a wealth of experience in equipping traditional port tugs with different types of fender protection, which is advisable to use to determine the equipment of unmanned vessels. The fender protection must be installed depending on the conditions in which production tasks will be performed, in addition, high operational requirements must be imposed on the fenders, due to the absence of people on board who can fix the separation of the protection and take measures to replace it in a timely manner. These conditions may depend on the types of production tasks that an unmanned port tug will perform. For example, the mooring of a bulk carrier and a tanker has some features, and entails the need to change the fender protection. Also, the various designs of the fender protection elements currently used on port tugs are analyzed in the paper. It allows structuring the main features when choosing a fender protection for an unmanned port tug, such as the towing method, the size of the tug, the size of the contact spot and other conditions.
The selection of the control unit optimal signalling sequence in containers stack handling at sea port terminal
Authors: Soloveva E. E. , Malikova T. E.
Published: July 2023

The possibility of increasing the productivity of technological operations performed in the storage area of a container terminal due to the introduction of automation elements into mechanized warehouse cargo handling has been researched. As one of the possible automation options, a method for transporting and storing containers with the implementation of a loader control unit in the form of a deterministic finite automaton is proposed. The sequence of actions of the loader is simulated in the control unit by a line of encoded symbols generated by the transition diagram of the Mealy automaton. In this case, the transition diagram is an automatic programming tool allowed mathematically describing the logic of controlling the actions of the loader when it processes a stack of containers. As a result of generation at the output of the machine, several valid loader control lines are got. Each symbol of the control line corresponds to one action from the loader working cycle. It is required to find the control line that will bring the loader to the state, when the picking up of containers from the stack is completed, in the minimum number of actions. The object of the research is a variable sequence of loader actions during partial disassembly of the stack with its corresponding control line. To reduce the complexity of the task being solved, each control line is divided into sections consisting of symbols responsible for the following actions of the loader: moving when changing the disassembled row, disassembling the row with the picking up and movement of target containers, returning blocking containers to the stacks where they were initially placed. As a result of the comparison of the corresponding symbolic sections of different lines, an algorithm that allows choosing the optimal sequence of signals for the control unit of the technological automaton in terms of the number of symbols is developed.
Efficiency of fuel gas supply on LNG-fueled vessels
Authors: Vatolin D. S.
Published: July 2023

The widespread use of LNG as a fuel for marine internal combustion engines makes to pay attention to the quality of gas fuel supply systems and its specifics. The objective of this paper is to review modern gas fuel supply systems and analyze their efficiency. The goal is to determine the most important parameters of gas fuel that affect the stability of the working process of marine dual-fuel engines and ways to maintain them within the specified limits. Evaluation of the gas fuel preparation efficiency is carried out on the basis of operational data obtained on the gas carrier vessel board. Data collection is carried out under non-standard operating conditions, which makes it possible to evaluate the quality of the resulting gas fuel with a time-varying composition of the initial natural gas. To analyze the obtained data, modern software, which is used by leading developers of marine diesel engines, is used (Wartsila Methane Number Calculator, AVL BoostTM and Python 3 statistic libraries). The analysis results are approximated for gas fuel supply systems for gas-fueled vessels, but not being gas carriers. This approximation is made taking into account the design features of gas fuel supply systems, since the specificity of the design imposes certain restrictions on the applicability of the conclusions obtained as a result of the previous analysis. Also, attention is paid to the accumulation of residual heavy hydrocarbons in bunker tanks, the excess of which can adversely affect the quality of gas fuel. Since there is no universal way to solve this problem, only general assumptions about possible ways to dispose of them have been made.
Research of models and methods for routing and practical implementation of autonomous movement by unmanned transport systems for cargo delivery
Authors: Kostin A. S. , Maiorov N. N.
Published: July 2023

Modern challenges in the field of transport logistics associated with the need to increase the speed of cargo transportation and reduce the cost of transportation require the development of solutions that will allow the introduction of unmanned vehicles to solve logistics problems. Within the framework of this paper, a new problem of routing an unmanned transport system through delivery points using annealing simulation methods and an ant colony algorithm is considered. These methods are chosen taking into account the real situation of complication of the conditions of possible delivery, the emergence of closed areas for delivery, obtaining a large number of points for delivery, or the emergence of other features. The selected algorithms are relatively simple to implement and, at the same time, form acceptable routes of movement, taking into account the initial data. These algorithms are studied in the software simulation environment Gazebo for the possibility of their application in unmanned transport systems and their effectiveness in constructing alternative traffic routes. In the software simulation, a program code for the autonomous movement of an unmanned vehicle is developed and a simulation environment is formed taking into account the test data. In the test environment, the results of the ant colony algorithm are checked against the test data, and special attention is paid to the study of the speed and accuracy of the selected algorithms. It is worth noting that the annealing simulation algorithm allows you to quickly optimize a given route, however, to obtain more accurate results, you should additionally use other optimization methods, such as the ant colony algorithm. As a result of the proposed methods application, it is concluded that it is possible to form the optimal route of movement relative to the initial data within the length of the path and the speed of the generated route.
Early formation of surface states in MOS structures under ionizing irradiation
Authors: Alexandrov O. V.
Published: July 2023

A quantitative model of the early formation of surface states (SS) in MOS structures under ionizing irradiation (II) with a limiting stage --- dispersion transport of holes has been developed. According to the model, the main contribution to the early formation of SS occurs during the microsecond pulse II for a thin gate dielectric and after the end of the pulse for a thick field oxide. The increase in the density of early SS after the end of II is associated with the presence of localized states and the dispersion transport of holes. The late formation of SS is limited by the dispersion transport of hydrogen ions, which delays the formation of late SS from 0.1 to 104 seconds or more. Keywords: MOSFET structure, ionizing irradiation, surface conditions, dispersion transport.
Peculiarities of changes in the intensities of the main photoluminescence bands of Tb-=SUP=-3+-=/SUP=- ions and their satellites in polycrystalline Gd-=SUB=-2-=/SUB=-O-=SUB=-3-=/SUB=- : Tb(3 mol%)
Authors: Bakovets V. V.  , Plyusnin P. E.  , Jushina I. V.  , Rakhmanova M. I.  , Sotnikov A. V.  , Dolgovesova I.P.  , Pivovarova T. D.
Published: July 2023

Samples of Gd2O3 : Tb(3 mol%) phosphor were obtained by sol-gel method followed by annealing at 800oC and 1200oC in air. At high annealing temperature, the intensities of the main emission bands 484 and 541 nm increase, but the ratio of the intensities of these emission bands to their satellites 493 and 549 nm respectively decreases. Based on the analysis of X-ray diffractometry, emission spectra, far-infrared and Raman spectroscopy, as well as diffuse reflectance spectroscopy, we established: the increase in the crystallinity of the samples with a significant reduction of the lattice strain stress at elevated annealing temperatures, changes in the structure of the bandgap with degenerated acceptor and donor zones of impurities Tb4+ and Tb3+ respectively. The diffuse reflection spectra of the sample after annealing at 800oC under optical excitation showed a direct charge transition through the bandgap with Eg=2.56 eV. After elevated annealing temperature the concentration of Tb4+ ions decreases due to reduction to Tb3+. As a result, at low excitation energies the degeneracy of the acceptor zone is still preserved and there is a direct transition of charges through the bandgap with Eg=2.55 eV. At high excitation energies the degeneracy of the acceptor zone is removed and there is a direct transition through the bandgap with Eg=3.39 eV. These effects are accompanied by a relatively large increase in the emission intensity of the satellites, especially at the 549 nm. Keywords: Gd oxide, Tb3++ photoluminescence spectra, far infrared and Raman spectroscopy spectra, structure of the bandgape, distribution of Tb3+ and Tb4+ in cation sublattice.
Excitation of terahertz radiation in p-n-heterostructures based on a-Si:H/c-Si
Authors: Andrianov A.V  , Aleshin A.N.  , Abolmasov S.N.  , Terukov E.I.  , Zakhar'in A.O.
Published: July 2023

Studies on the generation of terahertz (THz) radiation in p-n-heterostructures based on a-Si:H/c-Si upon their photoexcitation by a femtosecond titanium-sapphire laser with a wavelength of 800 nm are presented. The properties of observed THz radiation allow to explain its nature by excitation of fast photocurrent of nonequilibrium charge carriers created in the region of the potential barrier under femtosecond interband photoexcitation of the structure. The fast photocurrent, in turn, emits THz electromagnetic waves. The waveforms and amplitude spectra of the observed THz radiation reflect the dynamics of photoexcited charge carriers in the structures. The intensity of THz radiation observed in the studied p-n-heterostructures based on a-Si:H/c-Si is comparable to that generated in n-InAs crystals, which are widely used as emitters in systems of THz time-domain spectroscopy. Therefore, a-Si:H/c-Si p-n-heterostructures can be used as THz emitters for need of THz spectroscopy. Keywords: femtosecond laser photoexcitation, heterostructures, fast photocurrent, terahertz electromagnetic radiation.
Evolution of phase transitions and energy storage effect in SrTiO_3-PbZrO-=SUB=-3-=/SUB=- solid solutions
Authors: Smirnova E. P.  , Passet R. S.  , Sotnikova G. Yu.  , Zaitseva N. V.  , Guk E. G.  , Gavrilov G. A.
Published: July 2023

Solid solutions (1-x)SrTiO3-xPbZrO3 (x=0.5, 0.6, 07, 0.8, 0.9) were synthesized and their dielectric properties are investigated Measurement of dielectric hysteresis loops allowed us to obtain field dependences of the main parameters characterizing the effect of energy storage in these materials. The relationship of the obtained parameters with the evolution of the state of solid solutions from relaxors to antiferroelectrcs in this system is discussed. Keywords: solid solutions, energy storage effect, relaxors, antiferroelectrcs.
The effect of mindfulness therapy through an android application on nurses' work stress: A literature review
Authors: Triyanto Triyanto , Kamaluddin Ridlwan
Published: July 2023

Introduction: Several studies have shown that nurses have high levels of work stress. Work stress can be overcome with therapy, especially mindfulness therapy. The purpose of this literature review is to synthesize the literature on mindfulness therapy to reduce work stress for nurses.

Objectives : The formulation of the problem in this study is how to influence mindfulness therapy through an android applicationon work stress on work nurses in Emergency Room.

Methods: Literature search was carried out using several databases, including PubMed and Scient Direct. The keywords used are different in each database. For Pubmed use "mindfulness" and "online" and "workload" or "work stress" or "occupational stress" and “nurse”, meanwhile for scient direct use "mindfulness" and "online" or "app" and "workload" or "work stress" or "occupational stress" and "RCT".

Results: The search results from various literature obtained 360 articles, then through a series of selections, 67 match the criteria. These articles are publications from 2018 – 2023. but only 7 articles that are reviewed and in accordance with the research topic  and 2 articles not available cannot be accessed, 1 article another language. There were 4 selected articles left for review.

Conclusions: Nurses work have a high level of stress associated with a large workload. Work stress that is not handled properly can lead to social dysfunction and somatic disorders. Mindfulness-based stress reduction therapy is known effective in reducing the level of nurses anxiety, work fatigue, and work stress. Direct application or online is safe to give, because it does not have significant difference in effectiveness.
Risk Factor of hyperemesis gravidarum incidence
Authors: Nurfadillah Widya , Rosyidah Rafhani , Rinata Evi , Purwanti Yanik
Published: July 2023

Background: Hyperemesis Gravidarum is severe and excessive nausea and vomiting, starting at 4 and 6 weeks of gestation and peaking at 8-12 weeks of pregnancy, and usually subsiding by 20 weeks of gestation. As a result of excessive nausea and vomiting, pregnant women are at risk of dehydration, vitamin and mineral deficiencies, losing 5% of body weight, and can even endanger the fetus's health.

Objective: to recognize the risk factors for the incidence of hyperemesis gravidarum to detect early and reduce the consequences of hyperemesis gravidarum.

Research Methods: This type of research is an analytical observational study with the research design of the Case Control method with a sample size of 240, and the ratio of cases and controls in the study is 1: 1.

Results: The results showed that risk factors have an association with the incidence of hyperemesis gravidarum, namely the age of pregnant women has a value (p = 0.014 <0.05, OR = 0.38, 95% CI: 0.184-0.7998). Parity with a value of (p=0.008, OR=2.14, 95% CI: 1.253-2.656). Gestational age was (p=0.000, OR= 49.63, 95% CI: 18.730-131.51). Education with a value of (p = 0.188, OR = 0.500, 95% CI: 0.204-1.228). Maternal occupation with a value of (p=0.002, OR= 2.34, 95% CI: 1.380-3.999). Maternal pregnancy spacing with value (p=0.004, OR=2.17, 95% CI: 1.298-3.642). Non-anemic pregnant women (p=0.032<0.05, OR= 2.36, 95% CI: 1.128-4.971) and status of pregnant women with value (p=0.004, OR= 2.22, 95% CI: 1.315-3.74).

Conclusion: Almost all risk factors studied had a relationship, but only maternal education in this study did not have a relationship. Maternal age, parity, gestational age, maternal employment, pregnancy distance, anemia, and BMI status are risk factors for hyperemesis gravidarum. By knowing these risk factors, it is hoped that health workers can detect early and anticipate to minimize the severity when pregnant women are exposed to HEG. 
Comparison of booklet educational media effectiveness toward exclusive breastfeeding adherence
Authors: Sholihah Nur Rahmawati
Published: July 2023

Background: Exclusive breastfeeding provides infants with breast milk and no additional food, water, or other liquids (except medicines and vitamins, if necessary) for the first 6 months of life. Current practice of exclusive breastfeeding in Indonesia among infants aged 4-5 months is 27%, while between age 5-6 months is 3.4%. The main contributing factors of the poor adherence to exclusive breastfeeding is the lack of knowledge, which affects behavior and motivation. Producing inclusive, appropriate, and acceptable media is essential to manage this issue.

Objectives: The current study aimed to compare the effectiveness between application and booklet as educational media toward mother's adherence in exclusive breastfeeding.

Methods: A quasi experimental study with pre-post test with control group design carried out. The research subjects were mothers with infants aged 4-6 months in the adminstrative area of the Gamping II Public Health Center, Sleman Regency and consist of 3 villages; Banyuraden (8 hamlet), Nogotirto (8 hamlet), Trihanggo (12 hamlet)  Sample determined with purposive sampling, while recruitment performed by simple random sampling. The number of samples in the control and intervention grups were 32 respondents, and total sample is 64. Exclusive breastfeeding adherence was evaluated by knowledge, and attitudes questionnaire, validated with breastfeeding record within 24 hours. Comparative analysis was performed with Mann Whitney and Mc Nemar test.

Results: p value yielded from pretest and posttest in the intervention group p=0.109. It was inferred that there was no significant difference of breastfeeding adherence in association with the intervention. The control group p value was p=0.039 indicating significant difference of adherence in breastfeeding practice.
Conclusions: Booklet improves adherence to exclusive breastfeeding due to the depth of materials, familiar for the intended audience, practical, easy for content distribution, visually captive, attractive and easy to use. In-app educational media could increase knowledge and attitudes in particular to exclusive breastfeeding
Characteristics of Dermatology Residency Program Morbidity and Mortality Conferences: A Survey of Program Directors (Preprint)
Authors: Alexander-Savino Carolina V , Morrell Dean S , Mervak Julie E , Bowers Edith V
Published: July 2023

UNSTRUCTURED
Globalization and Organization Performance in Nigeria —A Review of Literature
Authors: Alani Owoeye O. , Oluwole Binuyo A. , Aderonke Nwankwere I.
Published: July 2023

This study examined globalization and organization performance in Nigeria, a review of literature. Globalization has become an experience that has turned the entire world into a global business village that can not be ignored by any organization if maximum or improve performance is to be achieved. This study was conducted using data from a single source. Information was obtained from magazines, articles, journals, periodicals, textbooks, the internet, and other unpublished materials applicable to the work written by different authors on the current topical issue. The secondary source of data collection was therefore adopted with the data examined using the content analysis approach due to its dependence on the secondary source data.
Correlation between Body Mass Index and Physical Function and Fitness in College Students
Authors: Yuan Linglin , Cheng Yuemei , Gu Fuquan
Published: July 2023

Using a test method and mathematical analysis, the correlation between BMI and physical function and fitness of college students was analyzed, as a basis for maintaining appropriate weight and improving physical function and fitness among college students. The results: (1) BMI of college students generally had a normal distribution with a left-hand peak and a right-hand slow tail. There was no significant difference in the proportion of males and females in the normal BMI level. (2) A highly significant positive correlation was found between BMI grade distribution and physical function (P<0.01), and gender differences were minimal. (3) Standing long jump performance was strongly correlated with BMI (P<0.01). The best scores were all at normal weight. (4) The correlation between body mass index and sitting and reaching performance was not significant (P>0.05). (5) In boys, there was a highly significant negative correlation between pull-up performance and body mass index (P<0.01), and the best performance was found in the normal weight range. Among girls, there was a negative correlation between 1 minute sit-up performance and body mass index (0.01<P?0.05), with the lowest weight group showing the best performance. (6) In the 50m running test, BMI was significantly correlated with body mass index of college students (P<0.05), and the normal grade test score was the highest. (7) Boys’ BMI and 1000m running test scores showed a highly significant positive correlation (P<0.01), with the best performance occurring at low body weights. Results were found There was a significant positive correlation between BMI and 800m running test scores of girls (0.01<P?0.05), and the best in the range of normal body weight. Normal-weight people had the best physical function and fitness, while obese people had the worst.
Eficacia del ácido valproico comparado con levetiacetam en el tratamiento de la epilepsia generalizada: Una revisón sistemática y meta-análisis
Authors: Dzul-Toledo Rubi Angélica , Contreras-Gonz+alez Noé
Published: July 2023

Introducción. La epilepsia es un síndrome crónico, recurrente y paroxístico, con manifestaciones clínicas variadas que tienen causas diversas. Es un problema de salud frecuente en la población que afecta la calidad de vida de los pacientes. Las crisis epilépticas generalizadas involucran ambos hemisferios cerebrales y tienen su sustrato en un grupo de neuronas del centro-encéfalo; se subdividen en tres subtipos: crisis convulsivas, crisis de ausencias y crisis mioclónicas. Existen diversos medicamentos anticonvulsivantes, siendo el ácido valproico y el levetiracetam dos los más utilizados; no obstante, no hay evidencia suficiente respecto a la eficacia de ambos fármacos. Objetivo. Presentar una síntesis del conocimiento sobre la eficacia del ácido valproico comparado con levetiracetam para el tratamiento de la epilepsia generalizada a través de una revisión sistemática y un meta-análisis. Material y Métodos. Esta revisión se llevó a cabo acorde a los lineamientos de PRISMA mediante una búsqueda en las siguientes bases de datos: PubMed, Scopus, Lilacs, Scielo y Tesiunam para identificar los artículos relevantes publicados desde 1980 hasta diciembre de 2021. Resultados. Un total de 329 artículos fueron identificados, de los cuales 3 cumplieron con los criterios de elegibilidad y fueron incluidos en la revisión sistemática y el meta-análisis. Se encontró un efecto similar después de 6 meses de tratamiento con alguno de fármacos analizados para la epilepsia generalizada; no obstante, observamos que después de 12 meses el tratamiento con ácido valproico es 44% más eficaz que el tratamiento con levetiracetam para remitir la epilepsia generalizada (RM=1.44;IC: 1.08-1.92; p=0.01). Conclusiones. Nuestros hallazgos sugieren que el ácido valproico es más eficaz que el levetiracetam para el tratamiento de la epilepsia generalizada; no obstante, se requieren más estudios al respecto.
How Libraries in Indonesia Use TikTok: A Content Analysis of Library Accounts on the Platform
Authors: Fadhli Rahmat , Ibrahim Cecep , Igiriza Miftahunnisa' , Ilmi Bachrul
Published: July 2023

The objective of this study is to examine Indonesian libraries’ TikTok accounts. The research was carried out on 12 TikTok accounts with a total of 688 posts to gain a better understanding of TikTok content, the type of information published, and follower engagement on posts. Data was collected by observing all TikTok accounts and posts. The result showed that most libraries began using TikTok in 2020, in response to the growing number of TikTok users and the shift during the pandemic. The most common types of published data are library collection information and other information. Announcements, services, and library facilities are the three types of information that receive the most engagement. This study has practical implications for libraries that use TikTok as a social media alternative. TikTok will allow them to reach younger audiences, boost creativity, spread joy, and save libraries’ money. Based on the findings of this study, librarians can consider the format of published information. This study offers insights on the social media platform TikTok as a new opportunity to promote libraries. It emphasizes the enormous potential for using social media platforms such as this to gain more attention and bring libraries closer to patrons.
CRISPR-Cas9 Gene Editing: Current Progress and Future Applications
Authors: Bishnoi Sundera
Published: July 2023

Abstract: Because of the groundbreaking gene-editing software clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR-Cas9), the field of molecular biology has been altered in a revolutionising way. It holds unparalleled potential for applications in a wide range of factors, including but not limited to biotechnology, agriculture, and medicine, since it allows for exact modifications to live creatures' DNA. This paper looks at the current state of CRISPR-Cas9 gene editing, its mechanics, recent advances, and ethical considerations. It also analyses the technology's potential future applications, emphasising its impact on human health, agriculture, and environmental protection.
Students' COVID-19 experiences: Integrating knowledge, attitude, and practices strategies for teaching science
Authors: Origenes Ritchelle , Alejandro Blanca A.
Published: July 2023

The junior and senior high school student experiences regarding their knowledge, attitude, and practices during the COVID-19 pandemic need to explore. This qualitative research uses a phenomenological technique with 20 students (10 JHS and 10 SHS) as a sample. Students learned about the illness through multimedia, filtering misinformation, self-driven data gathering, community support, and teacher-facilitated discussions. They also cultivated their attitude toward the disease through personal experiences and reflection on the pandemic, conducting activities such as experiments to test their acquired knowledge, considering community influences, and due to their self-motivation and appreciation of the right attitude during the pandemic. Finally, they executed practices toward COVID-19 with their parents' and peers' influence and support, collaborative team planning, learning from expert demonstrations, and participating in activity-driven action. JHS and SHS students have had a wide range of experiences during the COVID-19 pandemic regarding knowledge acquisition, inculcation of attitude, and practice implementation toward the disease. The student experiences are eye-openers to science educators. With this, there should be improvements in science education curricula that address the current pandemic and other unforeseen health issues.
PROMESAS PENDIENTES. PANORÁMICA Y ASPECTOS CRÍTICOS DE LA LEY N°21.430 DE GARANTÍAS Y PROTECCIÓN DE DERECHOS DE LA NIÑEZ
Authors: Estrada Vásquez Francisco
Published: July 2023

El 15 de marzo de 2022 se publicó la esperada ley N° 21.430, de garantías y protección integral de los derechos de la niñez y adolescencia, normativa que está llamada a ser la ley marco en derechos de la niñez en Chile. Este trabajo ofrece un panorama general de esta nueva ley, su estructura y características generales, los derechos y principios contenidos en ella, la regulación de la protección administrativa y las reformas a otras leyes. Luego, se plantea un análisis de cinco aspectos relevantes y problemáticos en esta normativa: la profusión de principios, la redundancia de numerosos derechos del catálogo, la inconsistencia de diversas disposiciones, el diseño confuso del procedimiento de protección administrativa y la repetición de los problemas de diseño de las Oficinas de Protección de Derechos (OPD) en las Oficinas Locales de Niñez.
ANTECEDENTES Y PERSPECTIVAS DE LA REGULACIÓN DE LA GESTACIÓN SUBROGADA EN COLOMBIA: ALGUNOS ASPECTOS PROBLEMÁTICOS
Authors: Rueda Natalia
Published: July 2023

Este artículo analiza, con una perspectiva crítica, las tres sentencias emitidas por la corte constitucional colombiana y los proyectos de ley de regulación de la gestación subrogada presentados desde 2016. Para ello, se describen los aspectos generales, con énfasis en el uso del lenguaje en las distintas fuentes, para mostrar algunas de las consecuencias prácticas. En particular, se pretende destacar la reelaboración del discurso en el derecho, que ha servido para legitimar lo que puede ser definido como una forma de explotación reproductiva.
La desigualdad como realidad histórica y vivencia social y humana: De Thomas Piketty a Alec MacGillis y Matt Taibi.
Authors: Vargas Solís Luis Paulino
Published: July 2023

Se ofrece aquí, una referencia crítica de cuatro libros de tres distintos autores: “El Capital en el Siglo XXI” y “Capital e Ideología”, del economista francés Thomas Piketty; “La brecha” y “Estados Unidos de Amazon: la historia del futuro que no es espera”, cuyos autores son, respectivamente, Matt Taibbi y Alex MacGillis, ambos periodistas estadounidenses. Se busca mostrar lo que tienen de común las cuatro obras, en cuanto el tema central que preocupa a sus autores es la desigualdad social. Desde ahí, el objetivo central de este artículo o reseña bibliográfica es demostrar la relación de complementariedad que hay entre las dos obras de Piketty, y los trabajos de MacGillis y Taibbi. En el primer caso, el abordaje es científico: se apoya en una enorme riqueza de fuentes y evidencia empírica, a la vez que aporta una amplísima perspectiva histórica, sociológica y política, más que solamente económica. Los otros dos autores asumen un enfoque periodístico, en mayor grado narrativo y anecdótico, gracias a lo cual logran aportar lo que está ausente en la obra de Piketty: la concreta dimensión humana de la desigualdad, la cual a menudo asume características lacerantes y sumamente dolorosas.
Tarihi Yerleşmelerde Batı Etkisinde (Geç) Osmanlı Dönemi Camileri: Konya/Sille Ak Cami
Authors: KULAK TORUN Firdevs , KURAK AÇICI Funda
Published: July 2023

Konya iline bağlı Sille yerleşmesi konumu sebebiyle geçmişte önemli bir yerleşim merkezi olmuştur. Sille tarih boyunca farklı toplumlara ev sahipliği yapmıştır. Hitit, Sümer uygarlıklarının da yaşadığı Sille yerleşmesi, Bizans’a ev sahipliği yaptığı dönemde Hıristiyanlık dini için merkez görevi görmüştür. Roma-Kudüs güzergâhında bulunması sebebiyle Kutsal Hac yolculuklarında uğrak nokta haline gelmiştir. Bu dönemde İpek ve Baharat yolları üzerinde bulunması yerleşmenin öneminin artırmıştır. Sille’de Türklerin hâkimiyet kurmaya başlaması ile önemli siyasi olaylar gerçekleşmiştir. Sille, Osmanlı döneminde ise Müslümanlık dini için de bir merkez olmuştur. Farklı toplumlara ev sahipliği yapması, dini ve ticari önemli güzergâhlar üzerinde yer alması sebebiyle zengin bir tarih yaşayan Sille, günümüzde de zengin kültürel mirası ile önemini korumaktadır. Yerleşmede Hıristiyanlık dinine ait kilise yapıları ve Müslümanlık dinine ait cami yapılarının yanı sıra, çeşme, hamam, köprü gibi birçok tarihi mimari yapı günümüze ulaşmıştır. Çalışma kapsamında ele alınacak yapı ise Müslümanlara ait olan yedi adet Batı Etkisinde (Geç) Osmanlı Dönemi camilerinden biri olan Ak Cami’dir. Ak Cami, Sille bölgesinde yer alan camiler arasında en eski tarihe sahip olan cami yapılarından biridir. Çalışma kapsamında Sille’de yer alan ilk Osmanlı Dönemi cami yapısı olan Ak Cami mekân ve strüktür açısından ele alınmaktadır. Çalışmada yöntem olarak yapıya dair literatür bilgileri, rölöveler, yerinde ölçümler ve fotoğraflardan yararlanılarak, yapının mekânsal ve strüktürel biçimi ortaya koyulmaktadır. Sonuç olarak Sille’nin en büyük camisi olan Ak Cami, cepheler, avlu, son cemaat yeri, minare, iç mekân, kadınlar mahfili, mihrap, minber, vaaz kürsüsü bakımından ele alınarak değerlendirilmiştir. Ardından yapının tarihlendirildiği döneminin cami mimarisi ile benzerlik ve farklılıkları karşılaştırılmıştır. Bu sayede yapının mimari özelliklerinin tarihlendirildiği dönem özellikleri ile arasındaki fark ortaya koyulmuştur.
Tanzimat ve Ticaret: Buharlı Çağında Ünye Limanı
Authors: BAY Abdullah
Published: July 2023

Karadeniz’in orta kesiminde yer alan Ünye Limanı, 18.yüzyıldan itibaren Tokat ve Amasya’da gelişen dokuma sektörüyle birlikte gittikçe önemini artırmıştır. Ünye İskelesi’nin önem kazanmasında coğrafi konumu ve iç kesimlere olan ulaşım kolaylığı etkili olmuştur. Liman, buharlı gemilerin bölgede seferlere başlaması ve Kuzey bölgelerinin Osmanlı egemenliğinden çıkmasıyla birlikte gittikçe gerilemiş, 19. yüzyılın ikinci yarısından itibaren art bölgesi ve ticari ağlarıyla yeniden gelişmeye başlamış, bunun sonucu olarak da nüfus artmış, önemli derecede göç yaşanmış, ekonomik faaliyetlere bir dinamizm gelmiştir. Kırım Savaşı’nın güney Karadeniz iskelelerine getirdiği hareketlilik bu gelişmenin diğer etkenlerinden bir diğeridir. Fakat asıl önemli sebep, 19. yüzyılda Osmanlı tarım ürünlerine olan Avrupa talebiydi. Doğu Karadeniz sahil yerleşimlerinin pek çoğunun gelişiminde ve bazılarının da bir iskeleden liman şehrine evrilmesinde, Avrupa ticaretinin Osmanlı limanlarında yarattığı üretim biçim ve ilişkilerindeki değişimin etkisini göz ardı etmek olanaksızdır. Amasya, Tokat, Sivas gibi geniş bir artalanın dışa açılan kapısı olan Samsun ve Ünye gibi limanların yükselişi bu dış talebin desteklediği istikrarlı tarımsal üretim artışından kaynaklanmıştı. Bu sayede yüzyılın sonlarına doğru Güney Karadeniz sahillerinin önemli limanları arasına giren Ünye önemli bir ticari hareketliliğe kavuşmuştu. Bu çalışmanın amacı, 19. yüzyılın ikinci yarısından itibaren öne çıkmaya başlayan Ünye iskelesinin ticari gelişimini ortaya koymaktır.
Vírgula: explicação ou complicação?
Authors: Marmentini Viviane , Vanzing Alceu
Published: July 2023

Este artigo busca observar, em diversos tipos de texto, o uso incorreto da vírgula e seus efeitos na comunicação. O artigo apresenta alguns textos com os problemas mais comuns de uso incorreto da vírgula, mostrando que tipos de problemas são encontrados ao fazer mau uso da pontuação, em especial, da vírgula. Faz uma rápida comparação entre a Gramática Tradicional e a Neopedagogia da Gramática e apresenta, detalhadamente, a vírgula pela Neopedagogia.
A quadrimorfia dos determinantes de nomes e verbos: um suporte para facilitar o trabalho de classificação das orações
Authors: Squeff Cíntia Haag , Fontes Arlinda Maria Caetano
Published: July 2023

Este trabalho aborda a Tese 01 da Neopedagogia da Gramática defendida pelo professor Francisco Dequi, do Centro de Estudos Sintagramaticais (CES): “No plano linguístico, falar ou escrever é determinar nomes e verbos com termos em forma de palavra, grupo nominal, oração reduzida ou oração desenvolvida”. Faz-se um estudo a respeito das relações de determinância entre os termos da oração, voltando a atenção, de modo especial, para a forma como cada determinante dos nomes e verbos se apresenta. Apontam-se algumas alternativas metodológicas que auxiliam o professor de língua portuguesa no desenvolvimento dos conteúdos curriculares, procurando compreender a gramática para aprimorar a produção textual. Examina-se um novo caminho que pode levar o estudante ao domínio gramatical da Língua Portuguesa, adotando a sintaxe calcada nos binômios nome/verbo e determinante/determinado. O determinado é sempre monovocabular e o determinante é quadrimórfico: apresenta-se como palavra, grupo nominal, oração reduzida ou oração desenvolvida. Com esta reflexão, mostra-se que é possível simplificar o ensino da sintaxe gramatical, tornando-a mais amena, objetiva e útil. Desmistificam-se as dificuldades em torno da classificação das orações, tornando-se evidente a função desse conteúdo de ensino, conduzindo-se a aprendizagem à percepção das regras linguísticas naturais que propiciam a emissão e a recepção das mensagens da comunicação em nível formal.
Apresentação
Authors: Guaresi Ronei
Published: July 2023

Apresentação à Edição número 1, volume 2, da Revista Virtual de Estudos de Gramática e Linguística, Língua Nostra
Estudo de caso de uma criança adquirindo a fonologia do português brasileiro: a emergência de templates
Authors: Baia Maria de Fátima de Almeida
Published: July 2023

Este estudo investiga a manifestação dos templates na aquisição inicial do português brasileiro e segue a perspectiva dinâmica de desenvolvimento e a Whole-Word Phonology. Após analisar a fala de uma criança de 9 a 24 meses, observamos momentos de uso e desuso de templates ao longo das sessões. Concluímos que a variabilidade no desenvolvimento fonológico ocorre devido à manifestação de templates e ao princípio da auto-organização.
PISA 2012 - BRASIL
Authors: De Mangueira Márcia Cristina Bonfim Ramos , Guaresi Ronei
Published: July 2023

Tradução da publicação dos resultados do PISA Brasil, ou seja, dos resultados dos estudantes brasileiros no Programa Internacional de Avaliação de Estudantes, o PISA, programa de avaliação organizado pela OCDE, Organização para a Cooperação e Desenvolvimento Econômico. A publicação dessa tradução, gentilmente permitida por representantes da OCDE, aponta evoluções e fragilidades do ensino brasileiro
Letramento e resgate cultural: relatório de aplicação de um projeto de letramento
Authors: Rodrigues Laurita Rodrigues de Amorim , Rocha Nei de Lima
Published: July 2023

O presente relatório de aplicação de um projeto de letramento foi realizado na unidade escolar Centro Educacional Jesuíno Flores, em uma das séries iniciais do Ensino Fundamental I, na turma do 3º Ano C, do turno vespertino. O desenvolvimento deste projeto de letramento teve o objetivo de estimular a curiosidade dos alunos à importância de resgatar os vários tipos de receitas de comidas típicas tradicionais das festividades do São João.
Reflexões acerca da gramática e da análise linguística no ensino de língua materna
Authors: Souza Sueder
Published: July 2023

rabalhar versando sobre atividades de Análise Linguística através dos gêneros, de conteúdos gramaticais ou de produções textuais nas aulas de língua materna, promove a ampliação das possibilidades do uso linguístico. Assim, os pressupostos norteadores do ensino de Português como língua materna recomendam práticas pedagógicas centradas na concepção interacionista da linguagem. Entretanto, ainda hoje é difícil encontrar essa visão subsidiando as atividades em sala de aula, sobretudo as atividades de Análise Linguística. Além da confusão estabelecida entre o ensino de Análise Linguística e o ensino da gramática tradicional, verifica-se também que as metodologias assumidas pelos docentes nem sempre favorecem uma reflexão acerca dos fenômenos linguísticos. Assim, este artigo pretende trazer para o campo da reflexão um debate sobre o ensino e a Análise Linguística, de forma a contribuir para reflexões e problematizações que possibilitam lançar luzes à prática docente.