bluuebunny/crossref_metadata_2025 huggingface dataset:
O desenvolvimento de doenças psiquiátricas em crianças após o diagnóstico de câncer: uma revisão integrativa
Authors: Bittencourt Anna Lillian Canuto , Cavalcanti Ana Cláudia Leal , Andrade Andreane Meneses , Almeida Anne Caroline Araújo , Soares Beatriz Luduvice , Da Silva Bruna Aparecida Siqueira , Reis Fernanda Fontes Prado , Rodrigues Letycia Santos , Meira Pedro Reges Pereira , Leal Iane Brito
Published: February 2021

Objetivo: Realizar um levantamento bibliográfico sobre o desenvolvimento de doenças psiquiátricas em crianças após o diagnóstico de câncer. Métodos: Trata-se de uma revisão integrativa da literatura realizada na base de dados em saúde PubMed.  Estratégias de busca foram realizadas com a utilização dos seguintes descritores em inglês: “Cancer”, “Child”, “Mental Health” AND “Psychopathology. Resultados: A primeira estratégia de busca com os descritores “Cancer”, “Child” AND “Mental Health”, foram encontrados 2.204 estudos científicos. Destes, foram selecionadas 2.051 produções que apresentavam o texto na íntegra, 1.646 relativos ao ano de publicação (entre 2013 e 2020) e 1.314 pertinente a espécie humana. Após a seleção por triagem pelos títulos e resumos restaram apenas 6 artigos científicos. A segunda estratégia de busca utilizou os descritores “Cancer”, “Child” AND “Psychopathology” e foram encontrados 130 artigos com os mesmos critérios de busca citados anteriormente. Desses, foram selecionadas 4 produções. Considerações finais:  O biopsicossocial da criança, que ainda se encontra em fase de adaptação após o diagnóstico da doença, sofre uma mudança brusca da rotina, sendo, por isso, os altos índices de transtornos de ansiedade e de depressão. Assim, elaborar e difundir o conhecimento sobre as psicopatologias nas crianças diagnosticadas com câncer é de suma importância.
Assistência odontológica ao paciente diabético
Authors: Neto José Milton de Aquino e Silva , Lima Lara Beatriz Henrique , Gomes Glayce Kelly Siqueira , De Mendonça Izabel Cristina Gomes
Published: February 2021

Objetivo: Analisar por meio de uma revisão narrativa sobre os cuidados odontológicos no atendimento aos pacientes diabéticos. Revisão bibliográfica: O diabetes é um distúrbio metabólico heterogêneo, de etiologia múltipla, caracterizado pelo aumento dos níveis glicêmicos no sangue resultante da produção insuficiente de insulina pelo pâncreas, por se tratar de uma doença crônica e irreversível, caracterizada por uma infinidade de complicações locais e sistêmicas como hipoglicemia, hiperglicemia, aterosclerose, retinopatia, nefropatia, neuropatias, úlceras diabéticas e o aumento da suscetibilidade a infecções. Com isso, evidências correlacionadas a odontologia, ressaltam que existe uma interligação entre pacientes diabéticos e o desenvolvimento de periodontopatias assim como implicações imunológias e alterações nas citocinas pró-inflamatórias, as quais afetam significativamente o processo de cicatrização de feridas cirúrgicas e a saúde dos tecidos da cavidade oral. Considerações finais: Nesse cenário, é de crucial importância o conhecimento do diabetes e suas complicações orais e sistêmicas, pelos Cirurgiões Dentistas (CD), antes de iniciar qualquer protocolo de tratamento em pacientes portadores dessa patologia, para que possa se cercar dos cuidados necessários a fim de evitar problemas que possam afetar permanentemente a vida dessas pessoas.
Relations between bipartite entanglement measures
Authors: Schwaiger Katharina , Kraus Barbara
Published: February 2021

We investigate the entanglement of bipartite systems from an operational point of view. Main emphasis is put on bipartite pure states in the single copy regime. First, we present an operational characterization of bipartite pure state entanglement, viewing the state as a multipartite state. Then, we investigate the properties and relations of two classes of operational bipartite and multipartite entanglement measures, the so-called source and the accessible entanglement. The former measures how easy it is to generate a given state via local operations and classical communication (LOCC) from some other state, whereas the latter measures the potentiality of a state to be convertible to other states via LOCC. We investigate which parameter regime is physically available, i.e. for which values of these measures does there exist a bipartite pure state. Moreover, we determine, given some state, which parameter regime can be accessed by it and from which parameter regime it can be accessed. We show that this regime can be determined analytically using the Positivstellensatz. We compute the boundaries of these sets and the boundaries of the corresponding source and accessible sets. Furthermore, we relate these results to other entanglement measures and compare their behaviors.
Constructing new q-ary quantum MDS codes with distances bigger than q/2 from generator matrices
Authors: He Xianmang
Published: February 2021

The construction of quantum error-correcting codes has been an active field of quantum information theory since the publication of \cite{Shor1995Scheme,Steane1998Enlargement,Laflamme1996Perfect}. It is becoming more and more difficult to construct some new quantum MDS codes with large minimum distance. In this paper, based on the approach developed in the paper \cite{NewHeMDS2016}, we construct several new classes of quantum MDS codes. The quantum MDS codes exhibited here have not been constructed before and the distance parameters are bigger than q/2.
Highly Sensitive Optical Sensor for Selective Detection of Fluoride Level in Drinking Water: Methodology to Fabrication of Prototype Device
Authors: Chatterjee Arka , Pan Nivedita , Maji Tuhin Kumar , Pasha Sheik Saleem , Singh Soumendra , Ahmed Saleh A. , Al-Thakafy Jalal T. , Pal Samir Kumar
Published: February 2021

Excess consumption of fluoride through drinking water and its detrimental effects on human health have been a serious global concern. Therefore, frequent monitoring as well as quantitative determination of fluoride ion (F-) concentration in aqueous media is of vital importance. Herein, we have developed a facile and highly sensitive spectroscopic technique for selective detection of F- in aqueous media using aluminium phthalocyanine chloride (AlPc-Cl) as a sensor. The absorbance as well as steady-state fluorescence intensity of AlPc-Cl has been found to decrease in presence of F- which has been used as a marker for the determination of fluoride ion concentration in water. The structural change in AlPc-Cl after addition of F- has been thoroughly studied by using 19F NMR (Nuclear Magnetic Resonance) spectroscopy. Our detailed steady-state as well as time-resolved fluorescence studies reveal that the quenching mechanism is static in nature due to ground state complexation in between F- and AlPc-Cl molecules. The response of the sensor is found to be linear over the F- concentration regime from 0 to 6 parts per million (ppm) with a detection limit of 0.05 ppm. Additionally, it shows an excellent selectivity as well as an insignificant change in sensitivity even in the presence of interfering iron and aluminium ions. Based on the detailed photophysical study, we have further developed a low cost and portable prototype device which shows an excellent sensitivity with the detection limit of 0.10 ppm. This prototype device has a high prospect for real-time monitoring of fluoride ion concentration especially in remote areas.
Investigating 3,4-Bis(3-Nitrofurazan-4-Yl)furoxan Detonation with a Rapidly Tuned Density Functional Tight Binding Model
Authors: Lindsey Rebecca , Bastea Sorin , Goldman Nir , Fried Laurence E.
Published: February 2021

Carbon rich materials lacking sufficient oxygen to undergo complete combustion have long been known to produce nanocarbon condensates of utility to industries spanning nanomedicine to quantum computing, when subject to strong shockwaves. However, the associated extreme conditions (e.g. 1000s of K and 10s of GPa) and rapid system evolution (e.g. 10s of ps) has precluded a clear understanding of early time phenomena giving way to carbon condensate formation. The semi-quantum density functional theory tight binding (DFTB) simulation method is ideal for studying chemistry on these timescales, offering much of the predictive power of density functional theory (DFT) at a fraction of the computational cost. However available parameterizations are not designed for application to organic molecular materials under extreme conditions.Here, we describe a new machine learning (ML) approach for rapidly tuning DFTB models to simulate molecular materials under extreme conditions and demonstrate its application to modeling of 3,4-bis(3-nitrofurazan-4-yl)furoxan (i.e. DNTF), which has recently been shown to produce liquid carbon nanodroplets upon detonation that subsequently solidify into graphitic nano-onions. We investigate early shockwave-driven decomposition chemistry to determine (1) major chemical kinetics steps, (2) the DNTF shock equation of state, and (3) implications of (1) and (2) for the DNTF nanocarbon formation mechanisms. We find evolution to be characterized by release of CO2, N2, and CO, as well as large CxNyOz species that are likely to be precursors to the experimentally observed carbon nano onions. Moreover, we find O purification (i.e. via CO2 elimination) more rapid than that of N (i.e. via N2 elimination), consistent with the experimentally observed N-containing species entrainment within the carbon condensates. Ultimately, we find the present developed ML-driven DFTB tuning approach well suited to the study of chemistry under extreme conditions, by providing a means of achieving long-timescale simulation with DFT-accuracy.
Wide Bite Angle Disphosphine Ligands in Thermally Activated Delayed Fluorescent Copper(I) Complexes: Impact on the Performance of Electroluminescence Applications
Authors: Li Chenfei , Mackenzie Campbell , Said Said , Pal Amlan , Haghighatbin Mohammad , Babaei Azin , Sessolo Michele , Cordes David , Slawin Alexandra , Kamer Paul , Bolink Henk , Hogan Conor , Zysman-Colman Eli
Published: February 2021

We report a series of seven cationic heteroleptic copper(I) complexes of the form [Cu (P^P) (dmphen)]BF4, where dmphen is 2,9-dimethyl-1,10-phenanthroline and P^P is a diphosphine chelate, in which the effect of the bite angle of the diphosphine ligand on the photophysical properties of the complexes was studied. Several of the complexes exhibit moderately high photoluminescence quantum yields in the solid-state, with ΦPL of up to 35%, and in solution, with ΦPL of up to 98%. We were able to correlate the powder photoluminescence quantum yields with the %Vbur of the P^P ligand. The most emissive complexes were used to fabricate both organic light-emitting diodes (OLEDs) and light-emitting electrochemical calls (LECs), both of which showed moderate performance. Compared to the benchmark Cu(I)-based LECs, [Cu(dnbp)(DPEPhos)]+ (EQEmax = 16%), complex 3 (EQEmax = 1.85%) showed much longer device lifetime (t1/2 = 1.25 h and >16.5 h for [Cu(dnbp)(DPEPhos)]+ and complex 3, respectively). The electrochemiluminescent properties of several complexes were also studied which to the best of our knowledge constitutes the first ECL study for heteroleptic copper (I) complexes. Notably, complexes exhibiting more reversible electrochemistry were associated with higher annihilation ECL as well as better performance in an LEC device.
CuH-Catalyzed Regio- and Enantioselective Hydrocarboxylation of Allenes: Towards Carboxylic Acids with Acyclic Quaternary Centers
Authors: Feng Sheng , Buchwald Stephen L.
Published: February 2021

We report a method to prepare α-chiral carboxylic acid derivatives, including those bearing all-carbon quaternary centers, through an enantioselective CuH-catalyzed hydrocarboxylation of allenes with a commercially available fluoroformate. A broad range of heterocycles and functional groups on the allenes were tolerated in this protocol, giving enantioenriched α-quaternary and tertiary carboxylic acid derivatives in good yields with exclusive branched regioselectivity. The synthetic utility of this approach was further demonstrated by derivatization of the products to afford biologically important compounds, including the antiplatelet drug indobufen.
Modern possibilities of radiological diagnosis of bladder cancer
Authors: Suchilova Maria M. , Nikolaev Aleksandr E. , Shapiev Arsen N. , Mukhutdinova Guzel Z. , Tkacheva Polina V. , Nikiforova Marina V. , Gombolevskiy Viktor A. , Morozov Sergey P.
Published: February 2021

Bladder cancer is one of the most severe and common diseases of genitourinary organs. According to WHO statistics, bladder cancer is the tenth in cancer morbidity structure and the 13th in cancer mortality structure in the world. In Russia, bladder cancer is 11th in cancer morbidity structure and 16th in cancer mortality structure. In most cases, bladder cancer is diagnosed at 6574 years of age. The 5-year survival rate for stage IV bladder cancer is about 15%. Early detection, correct staging, and management of the patient influence the prognosis and further quality of life. This review shows detection and staging methods of bladder cancer, staging categories based on multiparametric magnetic-resonance imaging with the use of Vesical Imaging-Reporting and Data System (VI-RADS). Illustrations and a brief overview of alternative visualization methods of bladder lesions, and new approaches in assessment of digital medical images, radiomics and radiogenomics, are presented. In the future, these methods should help to determine the biological characteristics of the tumor without taking a biopsy.
Differentiated thyroid cancer
Authors: Bel’tsevich Dmitrii G. , Mudunov Ali M. , Vanushko Vladimir E. , Rumiantsev Pavel O. , Mel’nichenko Galina A. , Kuznetsov Nikolai S. , Podvyaznikov Sergei O. , Alymov Yuri V. , Poliakov Andrei P. , Fadeev Valentin V. , Bolotin Mikhail V. , Sevriukov Feliks E. , Krylov Valerii V. , Fedenko Aleksandr A. , Bolotina Larisa V. , Zharov Andrei A. , Falaleeva Natalia A. , Filonenko Elena V. , Nevol’skikh Aleksei A. , Ivanov Sergei A. , Khailova Zhanna V. , Gevorkian Tigran G.
Published: February 2021

Differentiated thyroid cancer
The virtual forum on the diagnosis and treatment of PIK3CA-mutated metastatic breast cancer. October 16th, 2020. Event review
Authors: Poddubnaya Irina V. , Gligorov Joseph , Zhukova Liudmila G. , Kovalenko Elena I. , Frolova M. A.
Published: February 2021

The virtual forum on the diagnosis and treatment of PIK3CA-mutated metastatic breast cancer was held on 16th October 2020. The French and Russian oncology experts shared information and exchanged experience concerning the application of the first PI3K inhibitor alpelisib.
Impact of metabolic syndrome parameters and different fat depots on arterial stiffness in patients with abdominal obesity
Authors: Andreevskaia Marina V. , Zheleznova Ekaterina A. , Zhernakova Juliya V. , Chazova Irina E. , Shariia Merab A. , Blinova Nataliia V. , Zairova Alsu R. , Azimova Marina O. , Rogoza Anatolii N. , Saidova Marina A.
Published: February 2021

Overweight is closely associated with development of cardiovascular disorders. Currently, the terms metabolically healthy abdominal obesity (MHAO) and metabolically unhealthy obesity, i.e., metabolic syndrome (MS) are stated. Comparison target organs status and their link with fat depots in persons of these categories is of important scientific and practical interest.
Aim. To assess arterial stiffness in young people with abdominal obesity with / without MS by various methods as well as its link with various fat stores and other metabolic factors.
Materials and methods. 116 people, 18- to 45-year-old, with abdominal obesity were divided into two groups: MHAO (n=46), aged 40 [34; 43] years and MS (n=70), aged 40 [35; 44] years. The control group (CG) included 16 conditionally healthy volunteers without obesity, aged 32 [27; 35] years (p0.01). All subjects were assessed for height, body weight, body mass index, and waist circumference. Lipid profile, glucose, 2-hour glucose tolerance test, insulin, leptin, adiponectin, HOMA-IR were determined. 24-hour blood pressure monitoring was performed. Subcutaneous, visceral, perivascular, epicardial fat volumes and, the ratio of subcutaneous fat to visceral fat were determined by computed tomography. Arterial stiffness was determined according to CAVI (Cardio-Ankle Vascular Index), brachial-ankle pulse wave velocity baPWV (VaSera 1000), aortic pulse wave velocity aoPWV (EnVisor ultrasound system).
Results. aoPWV were significantly different between groups (p0.01). In persons with MS: 6.61.1 m/s, in MHAO and CG groups: 4.30.9 m/s and 5.51.0 m/s, respectively. Significant differences in baPWV were found only in MS group 13.88.2 m/s (p0.01) compared with CG and MHAO groups: 10.981.2 and 12.33.8 m/s, respectively. The CAVI index did not differ significantly between groups. There were reliable relationships between aoPWV and baPWV and almost all MS factors. The highest correlation coefficient was between aoPWV and visceral (r=0.55; p0.01) and epicardial (r=0.45; p0.01) fats. A close relationship between aoPWV and HOMA IR was revealed (r=0.42; p0.01). Correlation analysis showed a higher quality relationship between aoPWV and MS markers, insulin resistance, and fat depots compared to baPWV. According to multivariate regression analysis, the main contribution to the formation aoPWV is made by body mass index, systolic blood pressure, and epicardial fat.
Conclusion. The most sensitive to metabolic factors and the volume of fat depots was aoPWV indicator. Significant differences on some metabolic risk factors and aoPWV between the control group and MHAO raises doubts about the correctness of the term metabolically healthy obesity.
Current approaches to rehabilitation of patients with chronic heart failure
Authors: Arutyunov G. P , Kolesnikova E. A , Rylova A. K
Published: February 2021

The paper provides a critical review of the specific features of treatment in patients with Functional Class III-IV chronic heart failure (CHF). In addition, the authors give the positive results of their own studies dealing with respiratory muscle training in CHF. Greater treatment adherence by a patient is promoted by the attraction of his/her relatives to the treatment process. For wider involvement of physicians in the problem, the authors arranged a Russian study to increase the adherence of patients with CHF to treatment and rehabilitation, by attracting patients’ relatives to this process.
Nekotorye aspekty vosstanovitel'nogolecheniya i pervichnoy reabilitatsii deteys tserebrokardial'nym sindromom
Authors: Degtyareva Elena Aleksandrovna , Zhdanova Ol'ga Ivanovna , Mikheeva Anna Anatol'evna , Avakyan Aleksandr Armenovich
Published: February 2021

Summary. Efficacy and safety of early use of succinate-emitting parenteral drugs in preterm infants with I-II degree
of myocard posthypoxic damage against the background of cerebral ischemia is confirmed on the basis of objective
criteria. Scheduled administration of succinate-emitting cardiocytoprotectors to infants with myocard
posthypoxic damage offers the possibility of rehabilitation and restoration in earlier time periods.
Energeticheskaya sostavlyayushchaya i ob\"emnyykrovotok gemodinamiki v magistral'nykharteriyakh u bol'nykh khronicheskoy serdechnoynedostatochnost'yu pozhilogo vozrasta
Authors: Efremushkin German Georgievich , Filippova Tat'yana Vasil'evna , Denisova Elena Anatol'evna
Published: February 2021

Summary. Background. There is no clear understanding of the value of minute volume of blood in distinct phases
of blood flow and the total of its value in some of the main arteries. Energy component of the different phases of
blood flow and pulse wave (PW) in elderly patients with chronic heart failure (CHF) remains poorly understood.
Purpose. To study the redistribution of the blood flow volume and its energy component in the main arteries in
aged patients with CHF.
Materials and methods. In total 56 (48,2%) patients with CHF of I-II degree, of which 5 (8,9%) women aged between
63 and 87 (on average 76,60,9) years were included into the study. Patients were examined with the use of doppler
scanning of the common carotid (CCA), brachial (BA) and femoral (FA) arteries, in which the diameter of the
arteries, volumetric blood flow rate (Q, cm3/s), minute volume of blood (cm3/min), specific kinetic energy (hV,
sm2/s2) blood flow and PW were determined.
Results. In alderly patients with CHF Q (cm3/s), and minute blood volume (m3/min) in the CCA, and the PA are already
in CHF of I degree much higher than their values in healthy subjects and further increased in CHF of II degree
in all phases of blood flow. In BA these indices remained within the values of those in healthy individuals. Total minute
volume of blood in 3 pairs of studied arteries in patients with CHF of I degree increased compared with healthy
in 1,5 times and in patients with CHF of II degree in 2,1 times. In CHF blood volume in the CCA in the phase of
rapid was increased, but hV of blood flow is not increased. In the CCA hV PW decreased more than 2 times in comparison
with healthy people. Thus, hV of blood moving through the main vessels positively associated with the minute
volume of blood and hV PW with extension velocity of the latter. Therefore in the CCA as the minute blood volume
increases at the same time the energy component of Q, cm3/s and PW decrease that apparently reduces the
possibility of damaging effect of an increased blood volume on the brain vessels.
Hypolipidemic therapy in patients with non-alcoholic fatty liver disease
Authors: Lazebnik L. B , Zvenigorodskaya L. A , Samsonova N. G , Cherkasova E. A , Melnikova N. V
Published: February 2021

Dyslipidemia is currently accepted to be one of the major risk factor for cardiovascular diseases and atherosclerosis. There is no question that the liver plays an important role in the development of atherogenic dyslipidemia and it is simultaneously a target organ, which results in the development of non-alcoholic fatty liver disease (NAFLD). The latter limits the feasibilities of adequate hypolipidemic therapy, thus increasing the cardiovascular risks. There is a need to use hepatoprotectors when atherogenic dyslipidemia in a patient with documented NAFLD is treated with statins and fibrates. The choice of hepatoprotectors depends on the stage of NAFLD. It is expedient to take statins in combination with ursodeoxycholic acid preparations in NAFLD at the stage of steatosis. A combination of statins and a cholesterol absorption inhibitor is more effective in achieving low-density lipoprotein cholesterol goals in patients with hypercholesterolemia. Intestinal microflora-normalizing agents (enteric antiseptics, pre- and probiotics) should be included into a complex of hypolipidemic therapy in patients with NAFLD. Key words: atherogenic dyslipidemia, non-alcoholic fatty liver disease, hypolipidemic therapy.
Kompleksnaya terapiya pri aterogennoydislipidemii i nealkogol'noy zhirovoybolezni pecheni
Authors: Cherkashova Elizaveta Andreevna , Zvenigorodskaya Larisa Arsent'evna , Samsonova Natal'ya Gennad'evna , Nilova Tamara Vasil'evna , Sil'vestrova Svetlana Yur'evna , Khomeriki Sergey Germanovich
Published: February 2021

Summary. Non-alcoholic fatty liver disease (NAFLD) is one of the major components of the metabolic syndrome.
NAFLD is now recognized as one of the major cardiovascular risk factors since cholesterol synthesis takes place in
the liver. In this connection, to choose hypolipidemic therapy that has well-known hepatotoxic effects is an intricate
problem. Of great importance in the pathogenesis of NAFLD is the impaired colonic microflora and hence elevated
levels of microbial waste products (short-chain fatty acids, endotoxin, nitric oxide), which should be also
kept in mind when treating atherogenic dyslipidemia. Statin + probiotic combination therapy used in patients with
NAFLD and atherogenic dyslipidemia is more effective than monotherapy in reducing the levels of cholesterol and
intestinal microflora metabolism products.
Vliyanie lipektomii peredney stenkizhivota na techenie metabolicheskogosindroma
Authors: Volokh Mariya Aleksandrovna , Khalimov Yuriy Shavkatovich , Shapovalov Vladimir Mikhaylovich , Gubochkin Nikolay Grigor'evich
Published: February 2021

Summary. Objective: to study the influence of surgical correction of abdominal obesity in patients with type 2 diabetes
mellitus on clinical course of metabolic syndrome (MS).
Design and methods: 181obesity and type 2 diabetes mellitus patients were studied. All patients were divided into
two groups.
First group consisted of 109 patients, who underwent lipoaspiration or abdominoplasty with subsequent medication.
Second group - 72 patients suffering from abdominal obesity and type 2 diabetes mellitus, were treated conservatively
without surgery.
MS was diagnosed by six criteria in 90 (82,5%) first group patients and in 57 (79,1%) second group patients. 19
(17,5%) patients in the first group and 15 (20,9%) - in the second had five diagnostic MS criteria.
Results. The study of patients serum lipid structure shows different results depending on the treatment technique. Anterior
abdominal wall lipectomy leads to much faster and significant improvement in main lipidogram features, especially
triglyceride and low-density lipoprotein concentration, which are the most important markers of MS progression.
Unlike patients with obesity and type 2 diabetes mellitus treated conservatively with medication, surgically treated
patients show fast and resistant improvement in cardonhydrate metabolism compensation markers, which are
decrease of serum fasting glucose and glycated hemoglobin levels.
Arterial hypertension stage II and III in the first group patients developed significantly less in 5 years after surgery
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Comprehensive rehabilitation of patients with coronary heart disease concurrent with anxiety and depression disorders
Authors: Repin A. N , Lebedeva E. V , Sergienko T. N , Karpov R. S
Published: February 2021

In cardiological inpatients, coronary heart disease (CHD) is concurrent with clinical anxiety and depression disorders in 43% of cases. Comorbidity of coronary disease and anxiety and depression disorders is more frequently encountered among women than among men (40 versus 22%) and among post-aortocoronary bypass patients. Depressive disorders substantially worsen the course of CHD due to the frequent development of myocardial infarction, low exercise endurance, and patients’ refusal to have endovascular and surgical treatments. Therapy with selective serotonin reuptake inhibitor (SSRI) antidepressants caused a reduction in anxiety and depression disorders along with the improved clinical course of CHD, as evidenced from angina pectoris and heart failure. No serious side effects were observed during continuous SSRI use. The proposed regimen for the joint follow-up, treatment, and rehabilitation of patients by a working group of cardiologists and psychiatrists within a biopsychosocial model of rehabilitation is effective. It may be extensively used in cardiology, in the outpatient setting in particular.
Study of the efficiency and safety of Ladasten therapy in patients with cardiovascular disease
Authors: Kopylov F. Yu , Nikitina Yu. M , Makukh E. A , Syrkin A. L
Published: February 2021

A trial was carried out to study the efficiency and safety of therapy with the new antiasthenic drug Ladasten. The findings suggest its high safety and efficiency and good tolerability of Ladasten in the treatment of asthenia and asthenic spectrum disorders, the development of which is associated with cardiovascular disease.
Preduprezhdenie serdechno-sosudistykhoslozhneniy u patsientov s faktorami riskas pozitsii dokazatel'noy meditsiny
Authors: Bubnova Marina Gennad'evna
Published: February 2021

Summary. This review embraces the modern principles of cardiovascular disease prevention (CVD) as well as two
important approaches to their prevention: non-drug treatments (correction of risk factors related to lifestyle) and
drug treatments. Clinical effects and indications for use of such drug groups as antiplatelet agents, lipid-lowering
drugs, angiotensin-converting enzyme are marked. The article focuses on the treatment characteristics of patients
with multiple coronary risk factors. The results of clinical study on the antihypertensive effectiveness of Lisinopril
in patients with high-risk of hypertension and multiple risk factors are presented.
Genetic predisposition to atherothromboses in patients with severe angina pectoris
Authors: Chumakova G. A , Momot A. P , Kozarenko A. A , Veselovskaya N. G
Published: February 2021

Objective. To study the prevalence of thrombosis allelic polymorphisms in patients with severe angina who have indications for myocardial revascularization. Design and methods. The study included 105 patients (87 men and 18 women) aged from 33 to 70 years who had angina III–IV functional class, with indications for myocardial revascularization. All the patients studied polymorphism of the inhibitor of tissue plasminogen activator I type (675 4G/5G) (PAI-I), mutations of the factor II-prothrombin (20210 G / A), mutations of the factor V Leiden (Arg 506 Gln) and polymorphism of the methylenetetrahydrofolate reductase (Ala 222 Val) (MTHFR). Results. The prevalence of these mutations and polymorphisms in patients with severe angina requiring revascularization of the myocardium in 3 times greater than in the group of healthy adolescents. Our data showed that the risk of severe angina is directly proportional, and the age of the clinical debut of CHD is inversely proportional to the number of studied genetic defects. Thrombophilic polymorphisms studied genes increases the effects of other cardiovascular risk factors such as male sex, smoking and leads to an earlier debut of clinical CHD. Conclusion. It is necessary to form the strategy of genetically-based population policy for the prevention of atherosclerosis, including coronary. Healthy persons with diagnosed thrombosis polymorphisms are need of active primary prevention of cardiovascular disease.
Khronicheskoe legochnoe serdtse:klassifikatsiya, klinika, diagnostika,lechenie. Chast' I
Authors: Polyakova Ol'ga Vladimirovna , Arabidze Grigoriy Guramovich
Published: February 2021

Summary. In the first part of this review both domestic and foreign data from clinical and experimental researches
relating to modern views on the definition, classification, clinical and morphological picture, as well as approaches
to the treatment of chronic pulmonary heart (CPH) are presented. The CPH classification in stages and functional
classes depending on the level of pulmonary failure, arterial oxygen saturation, right ventricular hypertrophy and
heart failure are given. Modern methods of diagnosing CPH are introduced as well.
Pleiotropic effects of statins at the present stage of their study (focus on atorvastatin). Part III. Mechanisms of the pleiotropy of statins
Authors: Aronov D. M
Published: February 2021

After making a detailed review on the cardiac and non-cardiac pleiotropic effects of statins, the author has attempted to present mechanisms for these effects. The author’s main point is that their non-cardiac pleiotropic effects in diseases of different organs and systems are exposed to statins thanks to the body’s established pathogenic modules that are available in diverse pathologies, including cardiovascular diseases; these are: type 2 diabetes mellitus, obesity, metabolic syndrome, and kidney, liver, and bronchopulmonary system disorders in microbial and viral diseases. In these diseases, the patients are found to have universal pathogenic modules of inflammation, oxidative stress, endothelial dysfunction, hyperangiotensinemia, and inadequate activation of peroxime proliferator-activated receptors. Statins exert an additional positive effect unassociated with their hypolipidemic activity on many of the above pathogenic modules. In most cases, the mechanism of action of statins could be revealed in the above diseases. Special investigations relying on the rules of evidence-based medicine are needed to confirm the found pleiotropic effects.
Expression of proinflammatory cytokines in stable angina
Authors: Zakirova A. N , Zakirova N. E
Published: February 2021

Objective: to evaluate the severity of immuno-inflammatory responses under stable stenocardia in patients with ischemic heart disease (IHD). Patients and intervention: the study included 83 patients suffering from IHD. Among them 30 cases were diagnosed as functional class (FC)-II stenocardia, 27 cases as FC-III stenocardia and 26 cases as FC-IV stenocardia. The control group included 25 healthy persons. For characterizing the immuno-inflammatory responses we examined the level of C-reactive protein (CRP), pro-inflammatory (IL-1b, IL-6, TNF-α) and anti-inflammatory (IL-4, IL-10) cytokines by the immunoenzymic procedure. Results: FC-II stenocardia showed normal levels of CRP and pro-inflammatory cytokines. FC-III stenocardia was associated with a moderate increase in markers of an inflammation. FC-IV stenocardia was characterized by maximum levels of CRP and pro-inflammatory cytokines. Conclusion. The intensity of immuno-inflammatory responses depends on more or less serious course of stenocardia in patients with IHD.
Comparative characteristics of hemodynamics in the right and left main arteries in elderly patients with hypertension and its change in complex treatment involving physical training
Authors: Efremushkin G. G , Lomakina N. A
Published: February 2021

The aim of the following work was to study the hemodynamics in symmetric main arteries (MA) and its changes in elderly patients with arterial hypertension (AH) under the complex treatment involving physical training (PT).Materials and methods. The study included 122 hypertensive patients aged 60-90 years (76,8 ± 1,3 years). Common carotid (CCA), femoral (FA) and the shoulder (SA) arteries with the definition of velocity and volumetric hemodynamic parameters in them were examined using complex dopplerography.Results. In elder hypertensive patients the MA were increased in comparison with healthy intima-media and the diameter of the arteries at lower speed and volume of blood flow indices mainly in the CCA. Drug treatment of several patients improved these figures only in the FA and SA. PT, when included in the medical complex of elderly patients with hypertension proved to have positively influenced the hemodynamics not only in the FA and SA, but in the CCA as well.Conclusion. Complex treatment of elderly hypertensive patients using PT improves blood circulation of the limbs and brain, increasing the oxygen supply of the latter.
Clinical and medico-social effectiveness of therapeutic training of patients with atrial fibrillation
Authors: Muromkina A. V , Nazarova O. A , Intyakova Yu. V
Published: February 2021

Lack of efficacy of treatment of patients with atrial fibrillation (AF) is partly due to their low adherence, stipulatedby a lack of disease awareness among the patients. The article describes a technique of therapeutic training of patients with atrial fibrillation, developed on the basis of Ivanovo State Medical Academy and its influence on patients' awareness about the disease, their treatment adherence and quality of life. Schooling for patients with atrial fibrillation also led to a decrease in the number of applications for inpatient and outpatient medical care due to the worsening of arrhythmia. Positive dynamics of these indicators was noted early after training, and also 3 years after its closure.
Statins in the treatment and the prevention of the progression of atherosclerosis of patients with coronary heart disease
Authors: Morozova T. E , Vartanova O. A
Published: February 2021

Statins, the most common drugs to lower lipid levels, are «strategic» products for the treatment of patients with coronary heart disease (CHD), atherosclerosis, having the ability to reduce the cardiovascular and total mortality. This class of drugs can slow down the course of atherosclerosis and makes it more benign. A special place among statin places rosuvastatin (Crestor®, «AstraZeneca») due to his number of advantages of pharmacological and clinical properties. Compared with other statins, he has a far more powerful inhibition of the enzyme by metansulfonilamidnoy group and the most hypolipidemic activity (reduction of LDL cholesterol by 45–50% from baseline) in combination with the good tolerability and economic advantages.
Cliniko-experimental research of trimetazidine efficiency at the myocardium ischemia
Authors: Romashchenko O. V
Published: February 2021

The randomized controllable clinical research of Trimetazidine (Preductal MB) efficiency was spent at 95 patients with a stable angina pectoris. There were revealed the authentic increase in 2 times of treatment’s clinical efficiency in patients, who in addition to basic therapy appointed Trimetazidine for the account of more expressed antianginal effect and increase of physical working capacity. Additional appointment of Trimetazidine at a myocardium ischemia promoted the reduction of energy deficiency and tissue hypoxia. Last position has proved to be true according to experimental data: at rats males of line Vistar at experimental IHD the introduction of Trimetazidine led to increase of recycling of carbohydrates with the power purposes in a cardiac muscle that was accompanied by signs of stabilisation of cardiomyocytes’ membranes and reduction of degree of tissue hypoxia.
Clinical use of the III generation calcium antagonist Amlotopin the treatment of patients with cardiovascular disease
Authors: Zadionchenko V. S , Shehyan G. G , Yalymov A. A
Published: February 2021

Despite the facts, revealing the mechanisms of pathogenesis and enhancing the effectiveness of the treatment of cardiovascular disease (CVD), the latter continues to be the leading cause of death and disability in the population. In this regard, the search for new treatments for CVD remains the most relevant in modern cardiology. In the treatment of CVD many classes of drugs are used, among which are calcium antagonists (AA). This class of drugs has been successfully used in the treatment of patients with arterial hypertension (AH) and coronary heart disease [1-3, 5].CA are a heterogeneous group of drugs that have the similar actionmechanism, but differ in a number of properties, including pharmacokinetics, tissue selectivity, effect on heart rate, etc. The main feature of all is the ability of CA to reversibly inhibit calcium current through the slow calcium channels. These funds are used in cardiology from the end of the 1960s and have since become so widely popular that in most developed countries they hold one of the first places on the prescription rate of drugs used for the treatment of cardiovascular disease. This is due, on the one hand, to the CA high clinical efficacy, and on the other to a relatively small number of contraindications to their purpose and the comparatively small number of side effects. [1, 2, 4, 5].
Self-monitoring of blood glucose as a basis for diabetes management
Authors: Mayorov A. Yu , Melnikova O. G , Filippov Yu. I
Published: February 2021

The article represents the review of issues of self-monitoring of blood glucose (SMBG) in diabetes treatment. The therapeutic purposes are considered when carrying out SMBG before and after the meals, accepted in Russia, providing an individualization depending on age, existence of severe complications and the risk of hypoglycemia. SMBG frequency is presented at various options of the antidiabetic therapy. The value of carrying out SMBG for the patient and the doctor is discussed. The principles of the work photometric and electrochemical glucometers are given. Issues of accuracy of blood glucose measuring accepted by the International organization for standardization for the systems of SMBG are presented. The reasons of errors to the system evaluation of blood glucose are connected with incorrect hand washing, improper coding of test strips, external conditions (altitude, temperature, humidity), hematocrit, acidosis, hyperlipidemia, concentration of oxygen in blood, exogenous interfering substances (some medicines). The structure and rules of maintaining the diary as the main way of the storage of results of SMBG are presented. Data of the international and Russian studies on an assessment of efficiency of SMBG are shown. The SMBG new methods are discussed in the section on continuous glucose monitoring.
Hypoglycaemia as predictor of cardiovascular accidents
Authors: Doskina E. V , Tankhilevich B. M
Published: February 2021

Diabetes mellitus type 2 is not only a chronic disease, but also refers to a group of constantly progressing pathologies. Regardless of the level of development of medicine and used therapeutic approaches, mortality from cardio-vascular complications of diabetes exceeds the figures of the General population. According to the results of Veterans Affairs Diabetes Trial it was revealed that severe hypoglycemia are predictors for the development of myocardial infarction and acute disturbance of cerebral blood circulation. Pledge of successful treatment of patients with type 2 diabetes is the adequate choice of target values of glycemia and maintaining it by means of a combination of curative (observance of dietary recommendations, reception of hypoglycemic drugs, etc.) and not drug-induced (by which primarily active self-monitoring of blood glucose) activities.
Calcium antagonist lercanidipine in hypertension
Authors: Baryshnikova G. A , Chorbinskaya S. A , Stepanova I. I
Published: February 2021

The article presents the results of studies on the effectiveness and safety of a III generation calcium antagonist lercanidipine in the treatment of hypertension. Lercanidipine treatment leads to a marked significant reduction in systolic and diastolic blood pressure without producing a significant effect on heart rate. The drug has organ-protective effect, reduces left ventricular hypertrophy, improves kidney function and has antiproteinuric action. Lercanidipine is well tolerated, less likely to cause peripheral edema compared with other calcium antagonists.
Effects of different doses of rosuvastatin on blood lipids and lipoproteins, endothelial function, and cerebral blood flow in patients with hyperlipidemia and cerebral ischemic stroke-complicated hypertension
Authors: Bubnova M. G , Semenova E. G , Aronov D. M , Batysheva T. T
Published: February 2021

Objective: to study the dose-dependent effect of rosuvastatin on blood lipids and lipoproteins (LP), endothelial functional activity, coagulation, and safety parameters in patients with hyperlipidemia (HLP) and hypertension after cerebral ischemic stroke (CIS). Subjects and method. The trial included 34 patients (mean age 59,4±7,4 years) with types IIa or IIb HLP and CIS-complicated hypertension. The patients were randomized to 2 groups: 1) rosuvastatin 10 mg and 2) rosuvastatin 20 mg. The trial lasted 12 weeks. The dose of rosuvastatin remained unchanged throughout the trial. The authors evaluated the impact of therapy on the blood concentration of lipids, LP, fibrinogen, end products of nitric oxide (NO) metabolism, and endothelin-1 (ET-1), cerebral blood flow by great cerebral artery Doppler ultrasound data, as well as the parameters reflecting the safety of the therapy. Results. After 12-week therapy with rosuvastatin 10 and 20 mg, there was a significant decrease in the level of cholesterol by 30 and 35%, low-density lipoprotein (LDL) cholesterol by 40 and 45%, and triglycerides by 18 and 26%, respectively. Increasing the dose of rosuvastatin was attended by a significant rise (by 18%) in the number of patients with target LDL cholesterol levels. Rosuvastatin therapy caused no changes in the high baseline level of fibrinogen. At the same time, at the rosuvastatin doses of 10 and 20 mg, the concentrations of end products of NO metabolism increased by 14,3 and 12,4%, respectively. The vasoprotective effect of rosuvastatin 20 mg showed itself just at therapy week 6. Significantly decreased ET-1 levels were found when rosuvastatin was given in a dose of 10 mg; this was directly related to the baseline concentration of ET-1. In the patients who had an ET-1 level of >0,51 fmol/ml, its drop was 22,5% (p
Opportunities of statusmetriya in evaluation of 10-year risk atherosclerosis clinical manifestations development
Authors: Svistov A. S , Bovtyushko P. V , Grishayev S. L , Nikiforov V. S , Filippov A. E
Published: February 2021

The information content of Framingham, SCORE model and, statusmetriya in the evaluation of the total ten-year cardiovascular risk in an isolated sample of 207 males without clinical manifestations of atherosclerosis was investigated. Detected that most of the observations from persons who had attained over a 10-year period of the combined end point, the models qualified incorrectly, which didn’t meet the requirements of individual risk assessment in a limited sample group of males. Statusmetrichesky algorithm, in contrast to the accepted system of risk stratification, significantly more of the entities attributed to high-risk and significantly less - to the low-risk category. Sensitivity of the model was 73,9%, specificity - 74,7%, the total information value - 74,5%.
Predictors of acute cerebrovascular stroke and death from the perspective of a biopsychosocial approach (population survey)
Authors: Shtarik S. Yu , Petrova M. M , Garganeyeva N. P
Published: February 2021

Among the adult population of Krasnoyarsk defined epidemiological situation of anxiety and depression and hypertension, as well as their relationship. Revealed that the depression and their progression are risk factors for acute cerebrovascular stroke, and high level of anxiety - a risk factor for acute cerebrovascular stroke and death.
Treatment for cardiac arrhythmias in pregnancy: Efficiency and safety
Authors: Bunin Yu. A
Published: February 2021

Pregnancy with its physiological neurohumoral and hemodynamic changes may cause new-onset cardiac arrhythmia or worsen existing arrhythmias. It is important to single out the arrhythmias in pregnant women, which pose no risk for mother or fetus and therefore are not a contraindication to vaginal delivery and occasionally need no medical treatment. On the other hand, the arrhythmias, that impair hemodynamics and those that are referred to as the so-called potentially malignant and malignant cardiac arrhythmias, require specific pharmacotherapy and, in a number of cases, invasive treatments. Arrhythmias pharmacotherapeutic challenges in pregnant women are determined by that many antiarrhythmic agents may be harmful to the fetus and that the results of controlled trials of this problem are few and conflicting. The paper covers the current areas and some disputable issues of medical and surgical treatments for a wide spectrum of supraventricular and ventricular arrhythmias in pregnant women and gives practical recommendations for the use of different classes of antiarrhythmic agents in them to stop and prevent cardiac arrhythmias depending on their fetal safety and the pattern of maternal cardiovascular and concomitant diseases.
Choosing an effective combination of the antianginal therapy for patients with stable angina pectoris using paired tests with physical exercise (guidelines)
Authors: Kokurina Ye. V , Kukushkin S. K , Bochkareva Ye. V , Metelitsa V. I
Published: February 2021

These recommendations contain the procedure for choosing patients with stable angina pectoris and effective combination therapy of antianginal drugs from the three main groups (nitrates, calcium channel blockers and b-blockers) by repeated tests with physical exercise on a bicycle ergometer. We show how to determine the optimal combination of these drugs to the patient considering clinical data, tolerability and acceptability of the proposed treatment.The guidelines are intended for cardiologists, therapist, specialists in functional diagnosis, and scientific workers specialized in cardiac units. The guidelinesare recommended by Educational and Methodological Association of medical and pharmaceutical education in Russian universities as a textbook for doctors’ postgraduate education system.